Dataset | Set_04_DMproB_versus_LMproB.phenotype_DMproB_versus_LMproB.cls #DMproB_versus_LMproB |
Phenotype | phenotype_DMproB_versus_LMproB.cls#DMproB_versus_LMproB |
Upregulated in class | LMproB |
GeneSet | HSA00230_PURINE_METABOLISM |
Enrichment Score (ES) | -0.6333713 |
Normalized Enrichment Score (NES) | -1.4508531 |
Nominal p-value | 0.03253796 |
FDR q-value | 0.8595763 |
FWER p-Value | 1.0 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | POLR2E | 3325 19699 | 107 | 1.249 | 0.0531 | No | ||
2 | PDE6D | 13897 3945 | 115 | 1.172 | 0.1080 | No | ||
3 | XDH | 22897 | 342 | 0.417 | 0.1154 | No | ||
4 | RRM1 | 18163 | 507 | 0.311 | 0.1212 | No | ||
5 | PDE4B | 9543 | 1057 | 0.166 | 0.0993 | No | ||
6 | POLE | 16755 | 1329 | 0.129 | 0.0907 | No | ||
7 | NT5C2 | 3768 8052 | 1363 | 0.125 | 0.0948 | No | ||
8 | ADCY9 | 22680 | 1425 | 0.118 | 0.0971 | No | ||
9 | POLR2J | 16672 | 1444 | 0.116 | 0.1016 | No | ||
10 | FHIT | 21920 | 1481 | 0.112 | 0.1049 | No | ||
11 | HPRT1 | 2655 24339 408 | 1551 | 0.106 | 0.1062 | No | ||
12 | POLR3A | 21900 | 1596 | 0.102 | 0.1086 | No | ||
13 | ENPP1 | 19804 | 1854 | 0.082 | 0.0986 | No | ||
14 | POLR2I | 12839 | 2115 | 0.064 | 0.0876 | No | ||
15 | POLD4 | 12822 | 2142 | 0.063 | 0.0892 | No | ||
16 | PDE4C | 8481 | 2729 | 0.039 | 0.0593 | No | ||
17 | ADCY6 | 22139 2283 8551 | 2830 | 0.035 | 0.0556 | No | ||
18 | NME6 | 3139 19297 | 2959 | 0.032 | 0.0502 | No | ||
19 | POLR2G | 23753 | 3189 | 0.028 | 0.0391 | No | ||
20 | AMPD1 | 5051 | 3246 | 0.027 | 0.0373 | No | ||
21 | ECGF1 | 22160 | 3486 | 0.023 | 0.0254 | No | ||
22 | NT5E | 19360 18702 | 3579 | 0.021 | 0.0215 | No | ||
23 | GDA | 4764 | 3675 | 0.020 | 0.0172 | No | ||
24 | GUCY1B3 | 15311 | 3679 | 0.020 | 0.0180 | No | ||
25 | PDE4A | 3037 19542 3083 3023 | 3810 | 0.018 | 0.0118 | No | ||
26 | PKLR | 1850 15545 | 3844 | 0.018 | 0.0109 | No | ||
27 | GUCY1A3 | 7216 12245 15310 | 3897 | 0.017 | 0.0089 | No | ||
28 | PDE7B | 19807 | 3963 | 0.017 | 0.0062 | No | ||
29 | ENTPD6 | 4496 2678 | 4307 | 0.014 | -0.0118 | No | ||
30 | AK1 | 4363 | 4469 | 0.013 | -0.0199 | No | ||
31 | PNPT1 | 20936 | 4828 | 0.011 | -0.0387 | No | ||
32 | NT5M | 8345 4175 | 4884 | 0.010 | -0.0412 | No | ||
33 | NME7 | 926 4101 14070 3986 3946 931 | 5152 | 0.009 | -0.0552 | No | ||
34 | ENTPD8 | 12996 | 5336 | 0.008 | -0.0647 | No | ||
35 | AMPD3 | 4383 2110 | 5370 | 0.008 | -0.0661 | No | ||
36 | GMPR2 | 2711 | 5464 | 0.008 | -0.0708 | No | ||
37 | PDE8B | 5756 | 5927 | 0.006 | -0.0955 | No | ||
38 | POLR2C | 9750 | 6278 | 0.005 | -0.1142 | No | ||
39 | PDE9A | 23301 | 6701 | 0.004 | -0.1368 | No | ||
40 | PDE1C | 5235 | 6716 | 0.004 | -0.1373 | No | ||
41 | ADCY5 | 10312 | 6880 | 0.004 | -0.1460 | No | ||
42 | AK5 | 6042 | 6946 | 0.004 | -0.1493 | No | ||
43 | PDE10A | 23387 | 6970 | 0.004 | -0.1504 | No | ||
44 | ALLC | 21093 2130 | 7081 | 0.004 | -0.1561 | No | ||
45 | ADCY2 | 21412 | 7149 | 0.003 | -0.1596 | No | ||
46 | GUCY2C | 1140 16954 | 7169 | 0.003 | -0.1605 | No | ||
47 | POLA1 | 24112 | 7190 | 0.003 | -0.1614 | No | ||
48 | PDE6G | 20119 | 7510 | 0.003 | -0.1785 | No | ||
49 | ENTPD1 | 4495 | 7588 | 0.003 | -0.1826 | No | ||
50 | GUCY2F | 24045 | 7883 | 0.002 | -0.1984 | No | ||
51 | POLR2B | 16817 | 7996 | 0.002 | -0.2044 | No | ||
52 | ITPA | 9193 | 8228 | 0.001 | -0.2168 | No | ||
53 | PDE11A | 10805 | 8387 | 0.001 | -0.2253 | No | ||
54 | ADCY3 | 21329 894 | 9063 | -0.000 | -0.2618 | No | ||
55 | ADCY8 | 22281 | 9222 | -0.000 | -0.2703 | No | ||
56 | ADK | 3302 3454 8555 | 9381 | -0.001 | -0.2788 | No | ||
57 | POLE2 | 21053 | 9793 | -0.001 | -0.3010 | No | ||
58 | ADCY4 | 2980 21818 | 10062 | -0.002 | -0.3154 | No | ||
59 | PAPSS2 | 6258 | 10962 | -0.003 | -0.3639 | No | ||
60 | RRM2B | 6902 6903 11801 | 11023 | -0.004 | -0.3670 | No | ||
61 | ENTPD3 | 19266 | 11757 | -0.005 | -0.4064 | No | ||
62 | ENTPD2 | 8713 | 11784 | -0.005 | -0.4075 | No | ||
63 | NPR2 | 16230 | 11788 | -0.005 | -0.4074 | No | ||
64 | PDE6H | 17257 | 12048 | -0.006 | -0.4212 | No | ||
65 | AMPD2 | 1931 15197 | 12251 | -0.006 | -0.4318 | No | ||
66 | POLR3K | 12447 7372 | 12445 | -0.007 | -0.4419 | No | ||
67 | ENTPD4 | 7449 | 12938 | -0.008 | -0.4681 | No | ||
68 | AK3L1 | 8564 | 13124 | -0.009 | -0.4777 | No | ||
69 | GUCY1A2 | 19580 | 13211 | -0.009 | -0.4819 | No | ||
70 | ENPP3 | 19803 | 13516 | -0.011 | -0.4979 | No | ||
71 | RRM2 | 5401 5400 | 13596 | -0.011 | -0.5016 | No | ||
72 | POLR1D | 3593 3658 16623 | 13609 | -0.011 | -0.5017 | No | ||
73 | PDE1A | 9541 5234 | 13627 | -0.011 | -0.5021 | No | ||
74 | POLR1B | 14857 | 13865 | -0.013 | -0.5143 | No | ||
75 | CANT1 | 13304 | 13900 | -0.013 | -0.5156 | No | ||
76 | GART | 22543 1754 | 14162 | -0.015 | -0.5290 | No | ||
77 | NT5C1B | 21315 | 14385 | -0.016 | -0.5402 | No | ||
78 | PDE4D | 10722 6235 | 14994 | -0.023 | -0.5720 | No | ||
79 | PRPS2 | 24003 | 15111 | -0.025 | -0.5772 | No | ||
80 | NPR1 | 9480 | 15690 | -0.037 | -0.6067 | No | ||
81 | POLR2A | 5394 | 15711 | -0.037 | -0.6060 | No | ||
82 | APRT | 8620 | 15911 | -0.043 | -0.6147 | No | ||
83 | NT5C | 20151 | 16035 | -0.048 | -0.6191 | No | ||
84 | IMPDH2 | 10730 | 16040 | -0.048 | -0.6170 | No | ||
85 | DGUOK | 17099 1041 | 16062 | -0.049 | -0.6159 | No | ||
86 | NUDT2 | 16239 | 16097 | -0.050 | -0.6153 | No | ||
87 | PKM2 | 3642 9573 | 16205 | -0.056 | -0.6185 | No | ||
88 | POLD3 | 17742 | 16230 | -0.057 | -0.6171 | No | ||
89 | IMPDH1 | 17197 1131 | 16527 | -0.070 | -0.6298 | No | ||
90 | POLE4 | 12441 | 16594 | -0.075 | -0.6299 | Yes | ||
91 | POLR1A | 9749 5393 | 16609 | -0.076 | -0.6271 | Yes | ||
92 | PDE7A | 9544 1788 | 16615 | -0.076 | -0.6237 | Yes | ||
93 | PDE5A | 15431 | 16624 | -0.077 | -0.6205 | Yes | ||
94 | PAPSS1 | 15419 | 16703 | -0.082 | -0.6209 | Yes | ||
95 | POLE3 | 7200 | 16748 | -0.086 | -0.6192 | Yes | ||
96 | AK2 | 8563 2479 16073 | 16788 | -0.089 | -0.6171 | Yes | ||
97 | ADA | 2703 14361 | 16857 | -0.093 | -0.6164 | Yes | ||
98 | NT5C3 | 17136 | 16899 | -0.096 | -0.6141 | Yes | ||
99 | PDE2A | 18170 | 16916 | -0.097 | -0.6104 | Yes | ||
100 | GMPR | 21651 | 16974 | -0.102 | -0.6087 | Yes | ||
101 | PAICS | 16820 | 16994 | -0.104 | -0.6048 | Yes | ||
102 | NUDT9 | 7897 | 17008 | -0.105 | -0.6006 | Yes | ||
103 | GUK1 | 20432 | 17082 | -0.110 | -0.5993 | Yes | ||
104 | POLR2K | 9413 | 17152 | -0.117 | -0.5975 | Yes | ||
105 | POLD2 | 20537 | 17227 | -0.125 | -0.5956 | Yes | ||
106 | PDE3B | 5236 | 17283 | -0.132 | -0.5924 | Yes | ||
107 | GMPS | 15578 | 17344 | -0.139 | -0.5891 | Yes | ||
108 | POLA2 | 23988 | 17357 | -0.140 | -0.5831 | Yes | ||
109 | ZNRD1 | 1491 22987 | 17365 | -0.141 | -0.5769 | Yes | ||
110 | ADSL | 4358 | 17460 | -0.149 | -0.5749 | Yes | ||
111 | PDE8A | 18202 | 17467 | -0.149 | -0.5682 | Yes | ||
112 | POLR3B | 12875 | 17526 | -0.158 | -0.5639 | Yes | ||
113 | ADCY7 | 8552 448 | 17585 | -0.166 | -0.5592 | Yes | ||
114 | POLR3H | 13460 8135 | 17586 | -0.166 | -0.5514 | Yes | ||
115 | POLR2H | 10888 | 17623 | -0.171 | -0.5453 | Yes | ||
116 | POLD1 | 17847 | 17746 | -0.187 | -0.5431 | Yes | ||
117 | PRIM1 | 19847 | 17773 | -0.191 | -0.5355 | Yes | ||
118 | DCK | 16808 | 17832 | -0.199 | -0.5292 | Yes | ||
119 | NME4 | 23065 1577 | 17834 | -0.200 | -0.5199 | Yes | ||
120 | ENTPD5 | 4497 | 17842 | -0.201 | -0.5108 | Yes | ||
121 | PPAT | 6081 | 18001 | -0.240 | -0.5080 | Yes | ||
122 | ATIC | 14231 3968 | 18078 | -0.266 | -0.4996 | Yes | ||
123 | NME2 | 9468 | 18085 | -0.268 | -0.4873 | Yes | ||
124 | NME1 | 9467 | 18100 | -0.274 | -0.4751 | Yes | ||
125 | NUDT5 | 15121 | 18195 | -0.316 | -0.4653 | Yes | ||
126 | PRPS1 | 24233 | 18248 | -0.353 | -0.4515 | Yes | ||
127 | ADSSL1 | 21136 2087 | 18575 | -1.859 | -0.3815 | Yes | ||
128 | RFC5 | 13005 7791 | 18606 | -3.043 | -0.2396 | Yes | ||
129 | NP | 22027 9597 5273 5274 | 18615 | -5.092 | 0.0001 | Yes |