Details for gene set VERHAAK_AML_NPM1_MUT_VS_WT

Table: GSEA Results Summary

Dataset	Set_03_wtNotch_versus_normalThy.phenotype_wtNotch_versus_normalThy.cls #wtNotch_versus_normalThy.phenotype_wtNotch_versus_normalThy.cls #wtNotch_versus_normalThy_repos
Phenotype	phenotype_wtNotch_versus_normalThy.cls#wtNotch_versus_normalThy_repos
Upregulated in class	normalThy
GeneSet	VERHAAK_AML_NPM1_MUT_VS_WT_DN
Enrichment Score (ES)	-0.6156009
Normalized Enrichment Score (NES)	-1.573249
Nominal p-value	0.0
FDR q-value	0.30430895
FWER p-Value	0.954

Table: GSEA details [plain text format]
	PROBE	DESCRIPTION (from dataset)	RANK IN GENE LIST	RANK METRIC SCORE	RUNNING ES	CORE ENRICHMENT
1	ITM2A	460576 4210086	94	2.617	0.0335	No
2	DPYSL2	2100427 3130112 5700324	166	1.977	0.0589	No
3	PALM	130601 3850017	217	1.788	0.0825	No
4	DLK1	1240138	569	1.036	0.0788	No
5	HSPG2	2510687 6220750	743	0.893	0.0826	No
6	FLNB	2510575	940	0.729	0.0827	No
7	ALDH2	4230019	1086	0.637	0.0842	No
8	H1F0	1400408	1179	0.588	0.0879	No
9	APP	2510053	1312	0.534	0.0886	No
10	HSPB1	6760435	1500	0.457	0.0852	No
11	ITM2C	780647	1512	0.452	0.0913	No
12	LMO4	3800746	1841	0.351	0.0787	No
13	AK3L1	7100601	1901	0.335	0.0804	No
14	ASS1	1580632 4070082	1996	0.311	0.0799	No
15	SLC38A1	520465	2110	0.281	0.0779	No
16	POLE	6020538	2348	0.226	0.0684	No
17	ATP9A	4780673 5390280	2359	0.225	0.0712	No
18	MX1	2690301 6840364	2414	0.215	0.0714	No
19	TGFBI	2060446 6900112	2530	0.191	0.0680	No
20	SERPING1	5550440	2664	0.171	0.0633	No
21	CHI3L1	1170039	2817	0.150	0.0573	No
22	WASF1	2060484	2925	0.136	0.0535	No
23	RPS6KA2	2970161 4730278	3077	0.123	0.0471	No
24	RUNX3	3800546	3117	0.119	0.0468	No
25	PPP1R16B	3520300	3138	0.117	0.0474	No
26	TCF3	5080022	3162	0.115	0.0478	No
27	ZAP70	1410494 2260504	3498	0.085	0.0309	No
28	GNG7	1940019	3651	0.074	0.0238	No
29	GYPC	2320102	3658	0.073	0.0245	No
30	PRKD3	5220520 5890519	3719	0.069	0.0223	No
31	ELA2	1570452 5270129	3772	0.066	0.0204	No
32	SERPINF1	7040367	3851	0.061	0.0171	No
33	HIST1H2BG	5670632	3859	0.061	0.0176	No
34	ERG	50154 1770739	3953	0.057	0.0134	No
35	NEDD4	460736 1190280	4015	0.053	0.0109	No
36	TNFRSF21	6380100	4046	0.052	0.0100	No
37	CAV1	870025	4187	0.047	0.0031	No
38	MSLN	2640048	4195	0.046	0.0034	No
39	GALC	2260685 4810161 6370040	4354	0.041	-0.0045	No
40	GSN	3830168	4386	0.041	-0.0056	No
41	CD69	380167 4730088	4401	0.040	-0.0058	No
42	FZD2	6480154	4543	0.037	-0.0129	No
43	OPTN	3940041	4734	0.032	-0.0227	No
44	SERPINE2	2810390	4785	0.031	-0.0250	No
45	PDE3B	2030563	4803	0.031	-0.0254	No
46	B4GALT6	1850176 2340687	4827	0.031	-0.0262	No
47	MPL	2360253	5021	0.027	-0.0363	No
48	NBL1	2480021	5034	0.027	-0.0365	No
49	CSF3R	670500 2640239 3440091 5690020	5120	0.026	-0.0408	No
50	CD48	1570647	5258	0.024	-0.0479	No
51	CCR2	1450519	5353	0.023	-0.0526	No
52	GATM	380671	5417	0.022	-0.0557	No
53	SH3BP4	3140242	5432	0.022	-0.0562	No
54	RBPMS	3990494	5451	0.022	-0.0568	No
55	FCER1A	1050671	5560	0.020	-0.0624	No
56	CD34	6650270	5733	0.019	-0.0714	No
57	FGFR1	2190095 4570161	5874	0.017	-0.0788	No
58	KCNE1L	4670092	6052	0.016	-0.0881	No
59	PTPRM	6370136	6248	0.014	-0.0985	No
60	SYNGR1	5130452 6650056	6434	0.013	-0.1084	No
61	TM6SF1	730181	6528	0.012	-0.1132	No
62	SPARC	1690086	6541	0.012	-0.1137	No
63	PTGER4	6400670	6552	0.012	-0.1140	No
64	ABLIM1	580170 3710338 6520504	6741	0.011	-0.1241	No
65	HGF	3360593	6813	0.011	-0.1278	No
66	P2RY5	3800136	7353	0.008	-0.1569	No
67	MYH11	7100273	7506	0.008	-0.1650	No
68	MEST	4780440 6620292	7694	0.007	-0.1751	No
69	GPA33	2650044	7842	0.006	-0.1830	No
70	ARHGEF12	3990195	7948	0.006	-0.1886	No
71	MST1	1400403	8042	0.005	-0.1935	No
72	ARHGEF17	2060008	8134	0.005	-0.1984	No
73	CLEC5A	6420139	8222	0.005	-0.2031	No
74	EPS8	7050204	8285	0.005	-0.2064	No
75	NPR3	1580239	8419	0.004	-0.2135	No
76	STK32B	7000204	8532	0.004	-0.2195	No
77	ST18	5720537	8669	0.003	-0.2269	No
78	FZD6	360288	8729	0.003	-0.2300	No
79	PTRF	2260204	8890	0.002	-0.2387	No
80	TRH	5050576	9211	0.001	-0.2560	No
81	GNAI1	4560390	9272	0.001	-0.2592	No
82	EVI1	2000193 2680494	9476	0.001	-0.2702	No
83	IFI16	6520601	9777	-0.000	-0.2865	No
84	PPP4R2	5890035	10436	-0.002	-0.3222	No
85	CD19	6940692	10822	-0.003	-0.3430	No
86	GPM6B	6220458	10936	-0.004	-0.3491	No
87	ICAM4	6770053	10978	-0.004	-0.3513	No
88	BANK1	50750	11124	-0.004	-0.3591	No
89	CD38	6100056	11248	-0.005	-0.3657	No
90	BAALC	5310133 6450170	11324	-0.005	-0.3697	No
91	NT5E	2030603 1400731	11378	-0.005	-0.3725	No
92	PAM	5290528	11508	-0.006	-0.3794	No
93	VLDLR	870722 3060047 5340452 6550131	11548	-0.006	-0.3814	No
94	DACH1	2450593 5700592	11569	-0.006	-0.3824	No
95	DCHS1	4850487	11756	-0.007	-0.3924	No
96	TRPM4	6980270	11803	-0.007	-0.3948	No
97	SPON1	1660301	11887	-0.007	-0.3992	No
98	SCRN1	6040025 6580019	11896	-0.007	-0.3995	No
99	GPSM2	2260053	11965	-0.008	-0.4031	No
100	TMOD1	3850100	12014	-0.008	-0.4056	No
101	P2RX5	5570427 6130435	12021	-0.008	-0.4058	No
102	CLDN15	4150270 4730592	12118	-0.008	-0.4109	No
103	MLLT3	510204 3850722 6200088	12161	-0.009	-0.4130	No
104	MEF2C	670025 780338	12418	-0.010	-0.4267	No
105	TKTL1	2810672 6760102	12426	-0.010	-0.4270	No
106	TRAF5	3290064	12470	-0.010	-0.4292	No
107	DHRS3	360609	12770	-0.012	-0.4452	No
108	PROM1	3170537	12810	-0.012	-0.4471	No
109	ROBO1	3710398	12858	-0.013	-0.4495	No
110	PMAIP1	1400717 5360047 5900039	12864	-0.013	-0.4496	No
111	POU4F1	2260315	12873	-0.013	-0.4498	No
112	BLNK	70288 6590092	12874	-0.013	-0.4497	No
113	AGTPBP1	1990735	13437	-0.017	-0.4799	No
114	IL5RA	4540091	13732	-0.021	-0.4955	No
115	PDE4B	4480121	13783	-0.022	-0.4979	No
116	RETN	1050041	14024	-0.026	-0.5106	No
117	TGFB1I1	2060288 6550450	14048	-0.026	-0.5114	No
118	TSPAN7	870133	14234	-0.030	-0.5210	No
119	CYP2E1	4480209	14353	-0.032	-0.5270	No
120	NCAM1	3140026	14373	-0.033	-0.5275	No
121	CST7	380369	14381	-0.033	-0.5274	No
122	ADCY3	2350347 3440242	14619	-0.039	-0.5397	No
123	MS4A3	2480309 2690086	14656	-0.040	-0.5411	No
124	SPRY1	450253 460093	14725	-0.043	-0.5441	No
125	RGS1	4060347 4540181	14872	-0.048	-0.5513	No
126	ZHX2	2900452	14917	-0.051	-0.5530	No
127	RHOBTB3	4010687	14925	-0.051	-0.5526	No
128	F2RL1	3290279	14955	-0.053	-0.5534	No
129	EGFL7	150113 670170 3840707	15073	-0.058	-0.5589	No
130	TSPAN13	1690450	15135	-0.062	-0.5613	No
131	FHL1	60278	15297	-0.073	-0.5689	No
132	TFPI	1400288 5550008	15382	-0.079	-0.5723	No
133	BPGM	5080520	15423	-0.083	-0.5733	No
134	LHFPL2	450020	15765	-0.117	-0.5900	No
135	MEF2A	2350041 3360128 6040180	15910	-0.135	-0.5959	No
136	CACNA2D2	520736	16007	-0.149	-0.5989	No
137	CD200	940725 5260647	16036	-0.151	-0.5982	No
138	CD7	3140465	16054	-0.155	-0.5968	No
139	HPGD	6770192	16057	-0.155	-0.5946	No
140	DEPDC6	730326 5820239	16066	-0.157	-0.5927	No
141	CD2	430672	16174	-0.174	-0.5960	No
142	TACSTD2	6660341	16465	-0.223	-0.6084	No
143	SNCA	5340673	16479	-0.225	-0.6058	No
144	IGFBP7	520411 3060110 5290152	16558	-0.240	-0.6065	No
145	CIITA	2650242	16605	-0.249	-0.6053	No
146	NARFL	2260372 4050341	16649	-0.255	-0.6039	No
147	KIT	7040095	16733	-0.270	-0.6044	No
148	PTGIR	2100563	16902	-0.313	-0.6089	Yes
149	YPEL1	6590435	16994	-0.337	-0.6088	Yes
150	PTPRCAP	6650075	17074	-0.364	-0.6078	Yes
151	CENTD1	2570592	17107	-0.376	-0.6039	Yes
152	BZRAP1	5290487	17289	-0.448	-0.6071	Yes
153	ITGA6	3830129	17446	-0.521	-0.6079	Yes
154	RAMP1	2320168	17482	-0.534	-0.6019	Yes
155	JUP	2510671	17545	-0.566	-0.5969	Yes
156	PRTN3	6900670	17554	-0.570	-0.5890	Yes
157	VPREB1	3520280	17565	-0.574	-0.5810	Yes
158	GATA3	6130068	17582	-0.581	-0.5733	Yes
159	ADIPOR1	3140440	17600	-0.588	-0.5656	Yes
160	RRAGD	670075	17623	-0.601	-0.5579	Yes
161	CD3D	2810739	17668	-0.628	-0.5510	Yes
162	MMP9	580338	17760	-0.688	-0.5458	Yes
163	GJA1	5220731	17809	-0.725	-0.5377	Yes
164	FOXO1A	3120670	17857	-0.757	-0.5291	Yes
165	VIL2	5570161	17954	-0.833	-0.5220	Yes
166	ISG20	1770750	17956	-0.834	-0.5097	Yes
167	EVL	1740113	17980	-0.850	-0.4984	Yes
168	TRIB2	4120605	18126	-1.035	-0.4910	Yes
169	PLXND1	5270682	18141	-1.047	-0.4763	Yes
170	UGCG	3420053	18155	-1.067	-0.4613	Yes
171	LCN2	2510112	18163	-1.085	-0.4456	Yes
172	LAMC1	4730025	18255	-1.255	-0.4320	Yes
173	GMPR	3990022	18280	-1.324	-0.4138	Yes
174	EHD3	5360484	18286	-1.339	-0.3943	Yes
175	SIDT1	7100010	18319	-1.420	-0.3751	Yes
176	SORL1	630204	18331	-1.454	-0.3542	Yes
177	MPO	2360176 2760440 5690176	18349	-1.516	-0.3327	Yes
178	IFITM1	1690601 3120438 6510075	18422	-1.788	-0.3103	Yes
179	EMP1	4120438	18497	-2.284	-0.2806	Yes
180	ALAS2	6550176	18511	-2.385	-0.2461	Yes
181	DNTT	670162	18519	-2.472	-0.2100	Yes
182	FGF13	630575 1570440 5360121	18534	-2.575	-0.1727	Yes
183	CCND2	5340167	18548	-2.713	-0.1334	Yes
184	SSBP2	2260725 2900400 4730711	18561	-2.849	-0.0920	Yes
185	TOX	3440053	18571	-3.029	-0.0478	Yes
186	PRODH	1240452	18588	-3.398	0.0015	Yes