Dataset | Set_03_truncNotch_versus_normalThy.phenotype_truncNotch_versus_normalThy.cls #truncNotch_versus_normalThy.phenotype_truncNotch_versus_normalThy.cls #truncNotch_versus_normalThy_repos |
Phenotype | phenotype_truncNotch_versus_normalThy.cls#truncNotch_versus_normalThy_repos |
Upregulated in class | truncNotch |
GeneSet | REACTOME_DIABETES_PATHWAYS |
Enrichment Score (ES) | 0.66414917 |
Normalized Enrichment Score (NES) | 1.6189972 |
Nominal p-value | 0.0 |
FDR q-value | 0.02872059 |
FWER p-Value | 0.276 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | RPL38 | 70040 4060138 6200601 | 1 | 8.746 | 0.1157 | Yes | ||
2 | RPL27A | 3130451 110195 6840494 | 3 | 8.163 | 0.2238 | Yes | ||
3 | PGK1 | 1570494 630300 | 11 | 5.024 | 0.2899 | Yes | ||
4 | TPI1 | 1500215 2100154 | 25 | 4.295 | 0.3461 | Yes | ||
5 | F2 | 5720280 | 113 | 2.509 | 0.3746 | Yes | ||
6 | PKM2 | 6520403 70500 | 160 | 2.217 | 0.4015 | Yes | ||
7 | ATP5J | 4210100 6900288 | 303 | 1.684 | 0.4161 | Yes | ||
8 | MBTPS1 | 1230273 4850152 6860605 | 346 | 1.595 | 0.4349 | Yes | ||
9 | NDUFS3 | 1690136 5340528 | 379 | 1.530 | 0.4534 | Yes | ||
10 | RPS19 | 5860066 | 558 | 1.260 | 0.4605 | Yes | ||
11 | SDHB | 3120398 4780113 3710435 | 615 | 1.174 | 0.4730 | Yes | ||
12 | ATP5G1 | 5290019 | 777 | 1.007 | 0.4776 | Yes | ||
13 | RPS24 | 5420377 | 816 | 0.978 | 0.4885 | Yes | ||
14 | ETFB | 2690025 | 917 | 0.901 | 0.4950 | Yes | ||
15 | GNAS | 630441 1850373 4050152 | 1003 | 0.849 | 0.5017 | Yes | ||
16 | ATP5E | 4120411 | 1036 | 0.825 | 0.5109 | Yes | ||
17 | DDOST | 2680731 | 1052 | 0.814 | 0.5208 | Yes | ||
18 | NDUFA10 | 5570347 | 1056 | 0.809 | 0.5314 | Yes | ||
19 | RPS3A | 2470086 | 1091 | 0.785 | 0.5399 | Yes | ||
20 | UQCRC1 | 520053 | 1118 | 0.769 | 0.5487 | Yes | ||
21 | MDH2 | 1850601 | 1242 | 0.693 | 0.5512 | Yes | ||
22 | NDUFB8 | 2260450 | 1245 | 0.689 | 0.5602 | Yes | ||
23 | SSR4 | 1340619 4150132 | 1320 | 0.641 | 0.5647 | Yes | ||
24 | ATP5D | 6550167 | 1359 | 0.625 | 0.5709 | Yes | ||
25 | SEC61B | 840113 4540687 | 1423 | 0.596 | 0.5754 | Yes | ||
26 | NDUFS2 | 4850020 6200402 | 1448 | 0.585 | 0.5819 | Yes | ||
27 | UQCR | 6130025 | 1455 | 0.582 | 0.5892 | Yes | ||
28 | NDUFA8 | 3460491 | 1530 | 0.550 | 0.5925 | Yes | ||
29 | NDUFB7 | 1850026 | 1532 | 0.549 | 0.5997 | Yes | ||
30 | NDUFB10 | 5900576 | 1568 | 0.536 | 0.6049 | Yes | ||
31 | NDUFV1 | 5420369 | 1571 | 0.535 | 0.6119 | Yes | ||
32 | RPL14 | 5080471 | 1699 | 0.486 | 0.6115 | Yes | ||
33 | ATP5A1 | 1990722 | 1730 | 0.479 | 0.6162 | Yes | ||
34 | NDUFS8 | 4150100 | 1826 | 0.446 | 0.6169 | Yes | ||
35 | RPS23 | 7100594 | 1859 | 0.437 | 0.6210 | Yes | ||
36 | ATP5O | 7000398 | 1907 | 0.426 | 0.6241 | Yes | ||
37 | SSR2 | 5390180 | 1959 | 0.411 | 0.6267 | Yes | ||
38 | NDUFB5 | 110685 | 1973 | 0.406 | 0.6314 | Yes | ||
39 | SDHD | 2570128 | 1985 | 0.399 | 0.6361 | Yes | ||
40 | SEC61G | 4120725 | 2015 | 0.392 | 0.6397 | Yes | ||
41 | NDUFA11 | 3780333 | 2023 | 0.389 | 0.6445 | Yes | ||
42 | IDH3G | 6860706 | 2070 | 0.376 | 0.6470 | Yes | ||
43 | COX8A | 3780500 | 2073 | 0.375 | 0.6518 | Yes | ||
44 | ATP5I | 6220047 | 2128 | 0.360 | 0.6537 | Yes | ||
45 | NDUFA7 | 5900722 | 2185 | 0.347 | 0.6552 | Yes | ||
46 | COX5B | 6550670 | 2406 | 0.291 | 0.6472 | Yes | ||
47 | NDUFA6 | 3990348 | 2408 | 0.290 | 0.6510 | Yes | ||
48 | NDUFS7 | 1740142 | 2448 | 0.280 | 0.6525 | Yes | ||
49 | IDH3A | 460332 | 2507 | 0.263 | 0.6529 | Yes | ||
50 | IGFBP4 | 2680309 5420441 | 2536 | 0.256 | 0.6548 | Yes | ||
51 | CYCS | 2030072 | 2600 | 0.239 | 0.6545 | Yes | ||
52 | SRP72 | 3990427 | 2628 | 0.233 | 0.6561 | Yes | ||
53 | NDUFS5 | 4010692 | 2649 | 0.228 | 0.6581 | Yes | ||
54 | NDUFC2 | 580075 | 2652 | 0.227 | 0.6610 | Yes | ||
55 | IGFBP6 | 1580181 | 2757 | 0.203 | 0.6580 | Yes | ||
56 | RPS3 | 1570017 2370170 | 2759 | 0.203 | 0.6606 | Yes | ||
57 | RPL18A | 4570619 | 2806 | 0.196 | 0.6607 | Yes | ||
58 | RPS2 | 1340647 | 2836 | 0.190 | 0.6617 | Yes | ||
59 | SRP19 | 780450 3120075 | 2874 | 0.184 | 0.6621 | Yes | ||
60 | COX6B1 | 3710440 6180438 | 2910 | 0.178 | 0.6626 | Yes | ||
61 | CS | 5080600 | 2925 | 0.176 | 0.6641 | Yes | ||
62 | ATP5F1 | 7000725 | 3053 | 0.158 | 0.6594 | No | ||
63 | RPS17 | 2360528 | 3144 | 0.146 | 0.6564 | No | ||
64 | ATP5J2 | 2630706 | 3531 | 0.106 | 0.6369 | No | ||
65 | PRKCA | 6400551 | 3576 | 0.103 | 0.6359 | No | ||
66 | PFKFB2 | 3940538 7100059 | 3612 | 0.099 | 0.6353 | No | ||
67 | RPS15A | 1170180 | 3656 | 0.096 | 0.6342 | No | ||
68 | CPE | 2940441 | 3678 | 0.094 | 0.6344 | No | ||
69 | IGFBP5 | 2360592 | 3826 | 0.086 | 0.6275 | No | ||
70 | RPS4X | 2690020 | 3851 | 0.084 | 0.6273 | No | ||
71 | IGF1 | 1990193 3130377 3290280 | 3874 | 0.082 | 0.6272 | No | ||
72 | ATP5C1 | 5910601 | 4263 | 0.064 | 0.6071 | No | ||
73 | SLC2A2 | 5130537 5720722 6770079 | 4512 | 0.055 | 0.5944 | No | ||
74 | RPL37A | 7040717 | 4523 | 0.055 | 0.5945 | No | ||
75 | COX7C | 2470047 | 4567 | 0.053 | 0.5929 | No | ||
76 | NDUFA9 | 2260280 | 4579 | 0.053 | 0.5930 | No | ||
77 | RPL4 | 2940014 5420324 | 4641 | 0.051 | 0.5904 | No | ||
78 | CTSL1 | 2350519 | 4707 | 0.049 | 0.5875 | No | ||
79 | RPS13 | 1570364 | 4737 | 0.048 | 0.5866 | No | ||
80 | FAU | 7100465 | 4820 | 0.046 | 0.5827 | No | ||
81 | HSPA5 | 5130671 | 4848 | 0.045 | 0.5819 | No | ||
82 | VAMP2 | 2100100 | 5047 | 0.040 | 0.5717 | No | ||
83 | RPL6 | 6040735 | 5150 | 0.038 | 0.5667 | No | ||
84 | GLP1R | 6420528 | 5308 | 0.035 | 0.5586 | No | ||
85 | RPSA | 2360408 2680736 | 5533 | 0.031 | 0.5469 | No | ||
86 | KCNJ11 | 2510131 | 5628 | 0.029 | 0.5422 | No | ||
87 | UQCRFS1 | 6620576 | 5664 | 0.029 | 0.5407 | No | ||
88 | COX7B | 2340504 | 5972 | 0.024 | 0.5244 | No | ||
89 | UQCRB | 1450047 | 5981 | 0.024 | 0.5242 | No | ||
90 | KLF4 | 1850022 3830239 5570750 | 6118 | 0.022 | 0.5172 | No | ||
91 | DLD | 4150403 6590341 | 6307 | 0.020 | 0.5072 | No | ||
92 | PLA2G7 | 4730092 | 6310 | 0.020 | 0.5074 | No | ||
93 | ABCC8 | 2810671 3120671 | 6364 | 0.020 | 0.5048 | No | ||
94 | PFKFB1 | 2370128 | 6587 | 0.018 | 0.4930 | No | ||
95 | PCSK2 | 360017 430528 5900619 | 6790 | 0.016 | 0.4823 | No | ||
96 | EIF2S1 | 5360292 | 6855 | 0.016 | 0.4790 | No | ||
97 | COX6A1 | 1050095 1450239 | 7039 | 0.014 | 0.4693 | No | ||
98 | RPL17 | 2690167 5690504 | 7463 | 0.012 | 0.4465 | No | ||
99 | NDUFB4 | 460348 5690594 | 7540 | 0.011 | 0.4426 | No | ||
100 | NKX2-2 | 4150731 | 7557 | 0.011 | 0.4418 | No | ||
101 | GCG | 6220735 | 7921 | 0.010 | 0.4223 | No | ||
102 | ERN1 | 2360403 | 8137 | 0.009 | 0.4108 | No | ||
103 | ADRA2A | 5340520 | 8586 | 0.007 | 0.3866 | No | ||
104 | SRP54 | 2970605 | 9099 | 0.005 | 0.3589 | No | ||
105 | NDUFB3 | 4610687 | 9545 | 0.004 | 0.3349 | No | ||
106 | PDX1 | 6660647 | 9581 | 0.004 | 0.3330 | No | ||
107 | KIF5B | 770397 5420168 | 9645 | 0.004 | 0.3296 | No | ||
108 | IGFBP1 | 5720435 | 10500 | 0.001 | 0.2834 | No | ||
109 | LEP | 4010053 | 10635 | 0.001 | 0.2761 | No | ||
110 | SYT5 | 4150082 | 10692 | 0.001 | 0.2731 | No | ||
111 | EXOC5 | 7000711 | 10889 | 0.000 | 0.2625 | No | ||
112 | RAP1A | 1090025 | 11113 | -0.001 | 0.2504 | No | ||
113 | RPL18 | 6380181 3870195 | 11276 | -0.001 | 0.2417 | No | ||
114 | IGFALS | 6350195 | 12214 | -0.004 | 0.1910 | No | ||
115 | SDHA | 7000056 | 12361 | -0.005 | 0.1831 | No | ||
116 | RPL27 | 1940088 | 12929 | -0.008 | 0.1525 | No | ||
117 | SUCLG1 | 1850082 5290270 | 13147 | -0.009 | 0.1409 | No | ||
118 | RPL41 | 6940112 | 13250 | -0.010 | 0.1355 | No | ||
119 | RPLP1 | 3140292 | 14068 | -0.020 | 0.0915 | No | ||
120 | CHRM3 | 6110725 | 14116 | -0.021 | 0.0892 | No | ||
121 | FFAR1 | 540112 | 14238 | -0.024 | 0.0830 | No | ||
122 | KLK3 | 1500278 | 14399 | -0.028 | 0.0747 | No | ||
123 | RPL37 | 3170494 3870750 4280494 | 14479 | -0.031 | 0.0708 | No | ||
124 | NDUFAB1 | 1980091 | 14593 | -0.035 | 0.0651 | No | ||
125 | OGDH | 3840333 6350100 | 14787 | -0.045 | 0.0553 | No | ||
126 | RPS21 | 3120673 | 14915 | -0.053 | 0.0491 | No | ||
127 | RPS28 | 3830221 | 15125 | -0.066 | 0.0386 | No | ||
128 | RPS29 | 580324 | 15133 | -0.066 | 0.0391 | No | ||
129 | RPS20 | 1740092 | 15135 | -0.066 | 0.0400 | No | ||
130 | RPS14 | 430541 | 15223 | -0.073 | 0.0362 | No | ||
131 | RPS16 | 510722 | 15242 | -0.074 | 0.0362 | No | ||
132 | RPL8 | 20296 | 15246 | -0.075 | 0.0371 | No | ||
133 | RPLP2 | 5290020 | 15294 | -0.080 | 0.0356 | No | ||
134 | RPL39 | 2370446 | 15430 | -0.093 | 0.0295 | No | ||
135 | COX4I1 | 5340427 | 15449 | -0.095 | 0.0298 | No | ||
136 | RPL28 | 6900136 | 15706 | -0.123 | 0.0175 | No | ||
137 | MMP2 | 2570603 | 15728 | -0.126 | 0.0181 | No | ||
138 | RPL5 | 840095 | 15789 | -0.133 | 0.0166 | No | ||
139 | RPS5 | 580093 | 15829 | -0.138 | 0.0163 | No | ||
140 | ATP5B | 3870138 | 15887 | -0.147 | 0.0151 | No | ||
141 | RPL19 | 5550592 | 15897 | -0.148 | 0.0166 | No | ||
142 | RPS25 | 520139 | 15910 | -0.149 | 0.0179 | No | ||
143 | UQCRC2 | 5550091 | 16156 | -0.188 | 0.0071 | No | ||
144 | PRKAR2B | 3130593 5220577 | 16324 | -0.221 | 0.0010 | No | ||
145 | SLC30A7 | 2230463 | 16478 | -0.258 | -0.0039 | No | ||
146 | NDUFA2 | 6020100 | 16510 | -0.267 | -0.0020 | No | ||
147 | RPL11 | 3780435 | 16558 | -0.279 | -0.0009 | No | ||
148 | COX6C | 1400020 | 16700 | -0.319 | -0.0043 | No | ||
149 | ETFDH | 4670358 | 16749 | -0.335 | -0.0024 | No | ||
150 | SRP14 | 5390747 | 16797 | -0.348 | -0.0004 | No | ||
151 | ATF4 | 730441 1740195 | 16819 | -0.355 | 0.0032 | No | ||
152 | SEC11A | 6420563 | 17041 | -0.428 | -0.0031 | No | ||
153 | PDHA1 | 5550397 | 17311 | -0.537 | -0.0106 | No | ||
154 | NDUFA4 | 6860364 | 17330 | -0.547 | -0.0043 | No | ||
155 | NFYA | 5860368 | 17576 | -0.672 | -0.0087 | No | ||
156 | IQGAP1 | 6660494 | 17683 | -0.732 | -0.0047 | No | ||
157 | NDUFS4 | 510142 1240148 4760253 | 18045 | -1.031 | -0.0106 | No | ||
158 | EXOC8 | 5860133 | 18173 | -1.214 | -0.0014 | No | ||
159 | NDUFC1 | 2570377 4200239 | 18450 | -1.918 | 0.0090 | No |