Dataset | Set_03_absentNotch_versus_truncNotch.phenotype_absentNotch_versus_truncNotch.cls #truncNotch_versus_absentNotch |
Phenotype | phenotype_absentNotch_versus_truncNotch.cls#truncNotch_versus_absentNotch |
Upregulated in class | absentNotch |
GeneSet | TTTGTAG,MIR-520D |
Enrichment Score (ES) | -0.6343256 |
Normalized Enrichment Score (NES) | -1.7257675 |
Nominal p-value | 0.0 |
FDR q-value | 0.005798735 |
FWER p-Value | 0.024 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | HES1 | 4810280 | 69 | 2.042 | 0.0320 | No | ||
2 | ATXN2 | 3940017 4810242 | 110 | 1.630 | 0.0583 | No | ||
3 | ETV5 | 110017 | 145 | 1.443 | 0.0818 | No | ||
4 | UBE2E3 | 2030347 3840471 | 322 | 0.956 | 0.0889 | No | ||
5 | TUSC2 | 1580253 | 853 | 0.515 | 0.0691 | No | ||
6 | RCE1 | 1980372 | 1010 | 0.460 | 0.0686 | No | ||
7 | ARRDC1 | 4850095 | 1095 | 0.433 | 0.0716 | No | ||
8 | CUEDC1 | 1660463 | 1262 | 0.384 | 0.0693 | No | ||
9 | VAMP2 | 2100100 | 1312 | 0.372 | 0.0732 | No | ||
10 | TXN2 | 2030402 | 1429 | 0.347 | 0.0729 | No | ||
11 | CCND1 | 460524 770309 3120576 6980398 | 1487 | 0.331 | 0.0756 | No | ||
12 | HES5 | 4920026 | 1521 | 0.325 | 0.0795 | No | ||
13 | FKBP1A | 2450368 | 2111 | 0.228 | 0.0515 | No | ||
14 | SCD | 2680441 | 2203 | 0.216 | 0.0503 | No | ||
15 | U2AF1 | 5130292 | 2308 | 0.199 | 0.0481 | No | ||
16 | SON | 3120148 5860239 7040403 | 2364 | 0.192 | 0.0485 | No | ||
17 | MTF2 | 50333 | 2383 | 0.189 | 0.0508 | No | ||
18 | SEMA4G | 5890026 | 2643 | 0.155 | 0.0394 | No | ||
19 | MDM1 | 510528 1780280 2680152 2690181 3060025 3120487 4210601 4540037 4610142 5290110 6400433 6480743 | 2935 | 0.120 | 0.0257 | No | ||
20 | CDC42BPB | 6350037 | 3056 | 0.109 | 0.0211 | No | ||
21 | NEUROG1 | 380341 | 3275 | 0.091 | 0.0108 | No | ||
22 | EGR3 | 6940128 | 3356 | 0.086 | 0.0079 | No | ||
23 | HNRPA0 | 2680048 | 3393 | 0.084 | 0.0074 | No | ||
24 | PPP1CB | 3130411 3780270 4150180 | 3643 | 0.070 | -0.0049 | No | ||
25 | EIF3S10 | 1190079 3840176 | 3676 | 0.069 | -0.0054 | No | ||
26 | LRBA | 3450402 | 3705 | 0.067 | -0.0058 | No | ||
27 | CPEB2 | 4760338 | 3815 | 0.063 | -0.0106 | No | ||
28 | DCAMKL1 | 540095 2690092 | 3860 | 0.061 | -0.0119 | No | ||
29 | GADD45A | 2900717 | 4152 | 0.051 | -0.0269 | No | ||
30 | SOCS5 | 3830398 7100093 | 4188 | 0.050 | -0.0279 | No | ||
31 | PHF6 | 3120632 3990041 | 4335 | 0.046 | -0.0350 | No | ||
32 | KDELR1 | 6760504 | 4394 | 0.045 | -0.0374 | No | ||
33 | DDIT4L | 3370292 | 4465 | 0.043 | -0.0404 | No | ||
34 | CDH2 | 520435 2450451 2760025 6650477 | 4488 | 0.042 | -0.0409 | No | ||
35 | ETS1 | 5270278 6450717 6620465 | 4503 | 0.042 | -0.0409 | No | ||
36 | RDX | 4200039 6550465 | 4652 | 0.038 | -0.0483 | No | ||
37 | SDC2 | 1980168 | 4673 | 0.038 | -0.0487 | No | ||
38 | NEBL | 1850369 2480286 | 5157 | 0.029 | -0.0745 | No | ||
39 | SCN3A | 4070309 | 5248 | 0.027 | -0.0789 | No | ||
40 | LRCH4 | 5220279 6510026 | 5279 | 0.027 | -0.0801 | No | ||
41 | RKHD3 | 6180471 | 5368 | 0.026 | -0.0844 | No | ||
42 | ZZZ3 | 780133 2320239 2640452 5080706 6550341 | 5446 | 0.025 | -0.0882 | No | ||
43 | NHLH2 | 6200021 | 5458 | 0.025 | -0.0884 | No | ||
44 | LRRN1 | 3290154 | 5484 | 0.024 | -0.0893 | No | ||
45 | ENAH | 1690292 5700300 | 5557 | 0.024 | -0.0928 | No | ||
46 | BTBD3 | 1980041 2510577 3190053 4200746 | 5617 | 0.023 | -0.0956 | No | ||
47 | GAD1 | 2360035 3140167 | 5619 | 0.023 | -0.0953 | No | ||
48 | RFX3 | 520121 4280519 5570519 6100184 | 5632 | 0.023 | -0.0955 | No | ||
49 | PIWIL4 | 3180471 | 5845 | 0.020 | -0.1067 | No | ||
50 | COCH | 1090136 | 5991 | 0.019 | -0.1143 | No | ||
51 | CASP8AP2 | 5910593 | 6084 | 0.018 | -0.1190 | No | ||
52 | CNTNAP2 | 360170 4280546 | 6107 | 0.018 | -0.1198 | No | ||
53 | ZFHX4 | 6110167 | 6149 | 0.018 | -0.1218 | No | ||
54 | HOXB5 | 2900538 | 6224 | 0.017 | -0.1255 | No | ||
55 | ATXN1 | 5550156 | 6310 | 0.016 | -0.1298 | No | ||
56 | GRM3 | 4540242 | 6362 | 0.016 | -0.1323 | No | ||
57 | HOXB6 | 4210739 | 6516 | 0.015 | -0.1404 | No | ||
58 | MAP3K2 | 380270 | 6621 | 0.014 | -0.1458 | No | ||
59 | PHLPP | 3440563 | 7008 | 0.012 | -0.1666 | No | ||
60 | JMJD1C | 940575 2120025 | 7044 | 0.011 | -0.1683 | No | ||
61 | ACTL6A | 5220543 6290541 2450093 4590332 5270722 | 7073 | 0.011 | -0.1697 | No | ||
62 | GPM6A | 1660044 2750152 | 7246 | 0.011 | -0.1788 | No | ||
63 | RFX1 | 540373 | 7254 | 0.010 | -0.1790 | No | ||
64 | RFX4 | 3710100 5340215 | 7401 | 0.010 | -0.1868 | No | ||
65 | DKK2 | 3610433 | 7413 | 0.010 | -0.1872 | No | ||
66 | ODC1 | 5670168 | 7435 | 0.010 | -0.1882 | No | ||
67 | OSBPL10 | 1980184 | 7576 | 0.009 | -0.1957 | No | ||
68 | SOX1 | 630026 | 7715 | 0.009 | -0.2030 | No | ||
69 | FBN2 | 50435 | 7862 | 0.008 | -0.2108 | No | ||
70 | EIF2C1 | 6900551 | 8027 | 0.007 | -0.2196 | No | ||
71 | GABRA1 | 130372 | 8190 | 0.007 | -0.2283 | No | ||
72 | KCNK1 | 1050068 | 8240 | 0.007 | -0.2309 | No | ||
73 | ARL4A | 6290091 | 8275 | 0.007 | -0.2326 | No | ||
74 | FOSL1 | 430021 | 8317 | 0.006 | -0.2347 | No | ||
75 | BHLHB3 | 3450438 | 8523 | 0.006 | -0.2458 | No | ||
76 | PTPN2 | 130315 | 8575 | 0.006 | -0.2485 | No | ||
77 | LPP | 1660541 | 8740 | 0.005 | -0.2573 | No | ||
78 | CRHBP | 5420181 | 8882 | 0.005 | -0.2649 | No | ||
79 | PRDM1 | 3170347 3520301 | 8961 | 0.004 | -0.2691 | No | ||
80 | TLOC1 | 4050309 | 8979 | 0.004 | -0.2699 | No | ||
81 | NRXN3 | 1400546 3360471 | 9006 | 0.004 | -0.2713 | No | ||
82 | SYNPR | 2810400 | 9032 | 0.004 | -0.2725 | No | ||
83 | HDGFRP3 | 6180451 | 9062 | 0.004 | -0.2740 | No | ||
84 | STX12 | 610451 | 9193 | 0.004 | -0.2811 | No | ||
85 | KLF11 | 6840739 | 9232 | 0.004 | -0.2831 | No | ||
86 | SLITRK3 | 5910041 | 9261 | 0.004 | -0.2845 | No | ||
87 | PTN | 5910161 | 9334 | 0.003 | -0.2884 | No | ||
88 | MTSS1 | 780435 2370114 | 9421 | 0.003 | -0.2930 | No | ||
89 | PURA | 3870156 | 9426 | 0.003 | -0.2932 | No | ||
90 | DACH1 | 2450593 5700592 | 9457 | 0.003 | -0.2948 | No | ||
91 | ABCA1 | 6290156 | 9595 | 0.003 | -0.3022 | No | ||
92 | CHES1 | 4570121 5700162 | 9627 | 0.003 | -0.3038 | No | ||
93 | SYT1 | 840364 | 9646 | 0.003 | -0.3047 | No | ||
94 | ABCC12 | 5550026 | 9650 | 0.003 | -0.3049 | No | ||
95 | GPM6B | 6220458 | 9951 | 0.002 | -0.3212 | No | ||
96 | CBX4 | 70332 | 10059 | 0.002 | -0.3270 | No | ||
97 | TBC1D15 | 870673 | 10078 | 0.001 | -0.3279 | No | ||
98 | NR5A2 | 1690180 6900050 | 10144 | 0.001 | -0.3314 | No | ||
99 | NOPE | 380156 | 10430 | 0.001 | -0.3469 | No | ||
100 | FBXO22 | 4760010 | 10482 | 0.000 | -0.3497 | No | ||
101 | SP4 | 3850176 | 10522 | 0.000 | -0.3518 | No | ||
102 | TAL1 | 7040239 | 10620 | 0.000 | -0.3571 | No | ||
103 | KIF11 | 5390139 | 10668 | 0.000 | -0.3596 | No | ||
104 | SRC | 580132 | 10877 | -0.001 | -0.3710 | No | ||
105 | TRPC4 | 6040022 | 10909 | -0.001 | -0.3726 | No | ||
106 | SERTAD2 | 2810673 6840450 | 10956 | -0.001 | -0.3751 | No | ||
107 | SEH1L | 4590563 | 11065 | -0.001 | -0.3810 | No | ||
108 | POLR2B | 3780138 | 11091 | -0.001 | -0.3823 | No | ||
109 | PPP3CA | 4760332 6760092 | 11156 | -0.001 | -0.3858 | No | ||
110 | NEUROG2 | 5420278 | 11185 | -0.001 | -0.3873 | No | ||
111 | SBF2 | 3060315 | 11284 | -0.002 | -0.3926 | No | ||
112 | PDZRN3 | 2340131 | 11351 | -0.002 | -0.3962 | No | ||
113 | GTPBP1 | 2230541 4560528 | 11388 | -0.002 | -0.3981 | No | ||
114 | PFN2 | 730040 5700026 | 11440 | -0.002 | -0.4008 | No | ||
115 | KLF12 | 1660095 4810288 5340546 6520286 | 11455 | -0.002 | -0.4015 | No | ||
116 | SNF1LK | 6110403 | 11550 | -0.002 | -0.4066 | No | ||
117 | TEAD1 | 2470551 | 11588 | -0.002 | -0.4086 | No | ||
118 | PDCL | 2340348 | 11667 | -0.003 | -0.4128 | No | ||
119 | MAFF | 4850577 5720286 | 11787 | -0.003 | -0.4192 | No | ||
120 | ABHD3 | 2370091 | 11839 | -0.003 | -0.4219 | No | ||
121 | IER5 | 2350575 | 11913 | -0.003 | -0.4259 | No | ||
122 | TIPARP | 50397 | 12046 | -0.004 | -0.4330 | No | ||
123 | ADD1 | 1500176 3060139 3390092 | 12153 | -0.004 | -0.4387 | No | ||
124 | HOXD3 | 6450154 | 12260 | -0.005 | -0.4444 | No | ||
125 | SLC35F1 | 3850164 | 12659 | -0.006 | -0.4659 | No | ||
126 | TMEM47 | 1660086 | 12663 | -0.006 | -0.4660 | No | ||
127 | KCNMA1 | 1450402 | 12686 | -0.006 | -0.4671 | No | ||
128 | PRPF4B | 940181 2570300 | 12696 | -0.006 | -0.4674 | No | ||
129 | POU4F2 | 2120195 2570022 | 12715 | -0.006 | -0.4683 | No | ||
130 | MEF2C | 670025 780338 | 12780 | -0.007 | -0.4717 | No | ||
131 | GIPC2 | 3800463 | 12781 | -0.007 | -0.4716 | No | ||
132 | NPTX1 | 3710736 | 12862 | -0.007 | -0.4758 | No | ||
133 | FMN2 | 450463 | 12944 | -0.007 | -0.4801 | No | ||
134 | USP33 | 780047 | 12960 | -0.008 | -0.4807 | No | ||
135 | NDFIP1 | 1980402 | 12963 | -0.008 | -0.4807 | No | ||
136 | RSBN1 | 7000487 | 12985 | -0.008 | -0.4817 | No | ||
137 | LIN28 | 6590672 | 13088 | -0.008 | -0.4871 | No | ||
138 | ADCYAP1 | 520086 | 13233 | -0.009 | -0.4948 | No | ||
139 | SP3 | 3840338 | 13383 | -0.010 | -0.5028 | No | ||
140 | NPAS4 | 2320204 4150154 | 13425 | -0.010 | -0.5048 | No | ||
141 | QKI | 5220093 6130044 | 13435 | -0.010 | -0.5051 | No | ||
142 | SNAP25 | 360520 | 13587 | -0.011 | -0.5131 | No | ||
143 | UBE3A | 1240152 2690438 5860609 | 13717 | -0.013 | -0.5199 | No | ||
144 | DAPK1 | 5570010 | 13837 | -0.014 | -0.5262 | No | ||
145 | RPS6KB1 | 1450427 5080110 6200563 | 13918 | -0.015 | -0.5303 | No | ||
146 | BIVM | 6040546 | 13943 | -0.015 | -0.5313 | No | ||
147 | UBQLN2 | 430397 1170594 4070121 | 13959 | -0.015 | -0.5319 | No | ||
148 | HOXA7 | 5910152 | 14071 | -0.017 | -0.5376 | No | ||
149 | PPARGC1A | 4670040 | 14182 | -0.019 | -0.5433 | No | ||
150 | GNAO1 | 2510292 6590487 | 14218 | -0.019 | -0.5448 | No | ||
151 | PTP4A1 | 130692 | 14223 | -0.019 | -0.5447 | No | ||
152 | SLC1A3 | 1500070 | 14246 | -0.020 | -0.5456 | No | ||
153 | SERPINF2 | 2470390 2690292 | 14251 | -0.020 | -0.5454 | No | ||
154 | PIP5K3 | 5360112 | 14260 | -0.020 | -0.5455 | No | ||
155 | HTR7 | 2680176 | 14293 | -0.021 | -0.5469 | No | ||
156 | RNF12 | 6860717 | 14379 | -0.022 | -0.5511 | No | ||
157 | WASF2 | 4850592 | 14490 | -0.025 | -0.5567 | No | ||
158 | USP47 | 2640497 | 14584 | -0.028 | -0.5613 | No | ||
159 | CLNS1A | 2970022 3190402 | 14672 | -0.031 | -0.5655 | No | ||
160 | ZNF22 | 780546 2320131 | 14731 | -0.032 | -0.5680 | No | ||
161 | SLITRK2 | 2640020 | 14757 | -0.033 | -0.5688 | No | ||
162 | RANBP2 | 4280338 | 14838 | -0.036 | -0.5725 | No | ||
163 | TCF7L2 | 2190348 5220113 | 14857 | -0.037 | -0.5729 | No | ||
164 | SLC35F5 | 2360369 | 14943 | -0.041 | -0.5768 | No | ||
165 | SOX11 | 610279 | 14979 | -0.043 | -0.5779 | No | ||
166 | CSTF3 | 3850156 5570458 | 14998 | -0.044 | -0.5782 | No | ||
167 | DNAJC6 | 4590438 5900070 | 15092 | -0.048 | -0.5824 | No | ||
168 | TRPS1 | 870100 | 15096 | -0.049 | -0.5817 | No | ||
169 | PDE4D | 2470528 6660014 | 15170 | -0.052 | -0.5848 | No | ||
170 | BRWD1 | 3130048 3140168 6400601 | 15171 | -0.052 | -0.5838 | No | ||
171 | CITED2 | 5670114 5130088 | 15257 | -0.057 | -0.5875 | No | ||
172 | UBE2L3 | 1690707 5900242 | 15283 | -0.058 | -0.5878 | No | ||
173 | NCAM1 | 3140026 | 15291 | -0.059 | -0.5872 | No | ||
174 | PRPF39 | 1090088 | 15307 | -0.060 | -0.5869 | No | ||
175 | ANKRD10 | 1240025 | 15362 | -0.064 | -0.5888 | No | ||
176 | STK17B | 130091 | 15425 | -0.067 | -0.5910 | No | ||
177 | IGF1 | 1990193 3130377 3290280 | 15490 | -0.071 | -0.5932 | No | ||
178 | XPO5 | 2850286 | 15539 | -0.074 | -0.5945 | No | ||
179 | PHF15 | 6550066 6860673 | 15583 | -0.078 | -0.5955 | No | ||
180 | HNRPM | 450497 4540451 | 15631 | -0.081 | -0.5966 | No | ||
181 | SORCS1 | 60411 5890373 | 15682 | -0.086 | -0.5978 | No | ||
182 | MLLT10 | 1410288 3290142 | 15695 | -0.087 | -0.5970 | No | ||
183 | RAI14 | 770288 1660075 | 15743 | -0.091 | -0.5979 | No | ||
184 | PCNP | 610768 | 15750 | -0.092 | -0.5967 | No | ||
185 | MAPKAP1 | 1660161 2450575 | 15922 | -0.107 | -0.6041 | No | ||
186 | TOX | 3440053 | 16274 | -0.149 | -0.6206 | No | ||
187 | MBNL2 | 3450707 | 16344 | -0.161 | -0.6215 | No | ||
188 | MECP2 | 1940450 | 16365 | -0.163 | -0.6198 | No | ||
189 | PUM1 | 6130500 | 16453 | -0.179 | -0.6214 | No | ||
190 | SFRS5 | 3450176 6350008 | 16484 | -0.186 | -0.6197 | No | ||
191 | TPST1 | 2570358 | 16753 | -0.242 | -0.6301 | Yes | ||
192 | VGLL4 | 6860463 | 16801 | -0.254 | -0.6282 | Yes | ||
193 | PHF2 | 4060300 | 16806 | -0.255 | -0.6240 | Yes | ||
194 | SIRT1 | 1190731 | 16815 | -0.257 | -0.6199 | Yes | ||
195 | DHX32 | 2680138 | 16860 | -0.267 | -0.6176 | Yes | ||
196 | PURB | 5360138 | 16916 | -0.280 | -0.6157 | Yes | ||
197 | ADIPOR1 | 3140440 | 16952 | -0.289 | -0.6126 | Yes | ||
198 | FNTA | 70059 | 17007 | -0.303 | -0.6102 | Yes | ||
199 | MOCS2 | 2940497 | 17012 | -0.304 | -0.6051 | Yes | ||
200 | PRDM2 | 780278 1940692 | 17294 | -0.381 | -0.6137 | Yes | ||
201 | NXF1 | 1570377 | 17319 | -0.391 | -0.6082 | Yes | ||
202 | ZFX | 5900400 | 17341 | -0.399 | -0.6023 | Yes | ||
203 | CBX3 | 1780592 3940008 | 17359 | -0.405 | -0.5962 | Yes | ||
204 | SULF2 | 460086 | 17380 | -0.414 | -0.5900 | Yes | ||
205 | SCN5A | 4070017 | 17398 | -0.420 | -0.5836 | Yes | ||
206 | MTA1 | 3830092 | 17432 | -0.430 | -0.5779 | Yes | ||
207 | PDCD4 | 3360403 5690110 | 17447 | -0.436 | -0.5710 | Yes | ||
208 | CUGBP2 | 6180121 6840139 | 17550 | -0.471 | -0.5683 | Yes | ||
209 | MAP3K7IP2 | 2340242 | 17639 | -0.508 | -0.5642 | Yes | ||
210 | BZW1 | 460270 | 17721 | -0.545 | -0.5590 | Yes | ||
211 | CCT8 | 6220019 | 17753 | -0.557 | -0.5510 | Yes | ||
212 | NEDD9 | 1740373 4230053 | 17787 | -0.570 | -0.5428 | Yes | ||
213 | CMTM4 | 360600 3520332 | 17834 | -0.595 | -0.5349 | Yes | ||
214 | SESTD1 | 1090333 3780593 | 17835 | -0.595 | -0.5245 | Yes | ||
215 | ARL8B | 3710368 | 17848 | -0.602 | -0.5146 | Yes | ||
216 | LRP11 | 1980324 | 17913 | -0.631 | -0.5070 | Yes | ||
217 | LRRC8D | 1780014 | 17935 | -0.642 | -0.4969 | Yes | ||
218 | SMOC2 | 1170170 | 17969 | -0.661 | -0.4871 | Yes | ||
219 | TRAM1 | 2340441 6620592 | 17982 | -0.667 | -0.4761 | Yes | ||
220 | ACACA | 2490612 2680369 | 18033 | -0.701 | -0.4666 | Yes | ||
221 | ELAVL1 | 4730497 | 18059 | -0.717 | -0.4554 | Yes | ||
222 | RNF44 | 5910692 | 18104 | -0.755 | -0.4446 | Yes | ||
223 | TMPO | 4050494 | 18166 | -0.804 | -0.4338 | Yes | ||
224 | PPP2CA | 3990113 | 18202 | -0.833 | -0.4211 | Yes | ||
225 | NFYB | 1850053 | 18226 | -0.854 | -0.4074 | Yes | ||
226 | NDEL1 | 2370465 | 18246 | -0.881 | -0.3930 | Yes | ||
227 | LUC7L | 6040156 6110411 | 18256 | -0.892 | -0.3779 | Yes | ||
228 | H3F3A | 2900086 | 18341 | -0.991 | -0.3651 | Yes | ||
229 | PPM1D | 1690193 | 18346 | -1.000 | -0.3479 | Yes | ||
230 | ELF1 | 4780450 | 18367 | -1.032 | -0.3309 | Yes | ||
231 | UBE3C | 3140673 | 18377 | -1.048 | -0.3130 | Yes | ||
232 | STK4 | 2640152 | 18411 | -1.123 | -0.2952 | Yes | ||
233 | SFRS6 | 60224 | 18439 | -1.185 | -0.2759 | Yes | ||
234 | CTCF | 5340017 | 18455 | -1.243 | -0.2549 | Yes | ||
235 | ATP2A2 | 1090075 3990279 | 18482 | -1.356 | -0.2326 | Yes | ||
236 | H3F3B | 1410300 | 18492 | -1.379 | -0.2090 | Yes | ||
237 | SFRS1 | 2360440 | 18511 | -1.447 | -0.1846 | Yes | ||
238 | EIF4G2 | 3800575 6860184 | 18522 | -1.497 | -0.1590 | Yes | ||
239 | ATF4 | 730441 1740195 | 18536 | -1.582 | -0.1320 | Yes | ||
240 | UHRF1 | 1410273 1660242 | 18538 | -1.595 | -0.1041 | Yes | ||
241 | SMOC1 | 840039 | 18549 | -1.657 | -0.0756 | Yes | ||
242 | HNRPDL | 1050102 1090181 5360471 | 18572 | -2.002 | -0.0418 | Yes | ||
243 | CUTL1 | 1570113 1770091 1850273 2100286 5340605 | 18597 | -2.519 | 0.0010 | Yes |