Dataset | Set_03_truncNotch_versus_wtNotch.phenotype_truncNotch_versus_wtNotch.cls #truncNotch_versus_wtNotch |
Phenotype | phenotype_truncNotch_versus_wtNotch.cls#truncNotch_versus_wtNotch |
Upregulated in class | wtNotch |
GeneSet | UVB_NHEK1_DN |
Enrichment Score (ES) | -0.5624497 |
Normalized Enrichment Score (NES) | -1.7828108 |
Nominal p-value | 0.0 |
FDR q-value | 0.04076267 |
FWER p-Value | 0.26 |
PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|---|
1 | ADRB2 | 3290373 | 91 | 3.156 | 0.0214 | No | ||
2 | IGF2BP3 | 2810161 4230338 | 214 | 2.664 | 0.0371 | No | ||
3 | PHC2 | 1430433 | 228 | 2.617 | 0.0582 | No | ||
4 | SMAD3 | 6450671 | 421 | 2.238 | 0.0665 | No | ||
5 | NAGK | 730041 3170086 5890053 | 556 | 2.070 | 0.0765 | No | ||
6 | CCNE1 | 110064 | 1324 | 1.384 | 0.0465 | No | ||
7 | SART3 | 6060646 | 1592 | 1.210 | 0.0421 | No | ||
8 | SSBP2 | 2260725 2900400 4730711 | 1689 | 1.151 | 0.0465 | No | ||
9 | MYST3 | 5270500 | 1802 | 1.077 | 0.0494 | No | ||
10 | USP24 | 870672 4560100 | 1804 | 1.076 | 0.0584 | No | ||
11 | DOCK9 | 5080037 | 2140 | 0.930 | 0.0480 | No | ||
12 | NFKB1 | 5420358 | 2374 | 0.822 | 0.0422 | No | ||
13 | PSCD1 | 110113 2470592 | 2437 | 0.787 | 0.0454 | No | ||
14 | BACH1 | 290195 | 2587 | 0.727 | 0.0434 | No | ||
15 | MKI67 | 3440750 4480072 7050288 | 3171 | 0.502 | 0.0160 | No | ||
16 | CEBPD | 3360176 | 3230 | 0.485 | 0.0169 | No | ||
17 | AKAP9 | 510184 2060195 2470136 4280048 | 3425 | 0.433 | 0.0100 | No | ||
18 | TAF5L | 5690152 | 3438 | 0.430 | 0.0129 | No | ||
19 | SHOC2 | 1340064 1570546 | 3455 | 0.426 | 0.0156 | No | ||
20 | HDHD1A | 6220328 | 3559 | 0.405 | 0.0134 | No | ||
21 | DDIT4 | 2570408 | 3564 | 0.404 | 0.0166 | No | ||
22 | CNOT2 | 520546 2060397 4610543 5550113 | 4083 | 0.305 | -0.0090 | No | ||
23 | CDYL | 4200142 4730397 6060400 | 4198 | 0.284 | -0.0128 | No | ||
24 | MEGF9 | 2320097 | 4318 | 0.269 | -0.0170 | No | ||
25 | FYN | 2100468 4760520 4850687 | 4389 | 0.260 | -0.0186 | No | ||
26 | SH2B3 | 4810451 4850128 | 4528 | 0.240 | -0.0241 | No | ||
27 | PLK4 | 430162 5720110 | 4615 | 0.232 | -0.0268 | No | ||
28 | USP1 | 2760541 5690438 6220673 | 4671 | 0.225 | -0.0279 | No | ||
29 | NFE2L2 | 2810619 3390162 | 4711 | 0.221 | -0.0282 | No | ||
30 | DOCK4 | 5910102 | 4925 | 0.199 | -0.0381 | No | ||
31 | PER2 | 3120204 3390593 | 5062 | 0.186 | -0.0439 | No | ||
32 | AHR | 4560671 | 5070 | 0.185 | -0.0428 | No | ||
33 | ARID5B | 110403 | 5496 | 0.151 | -0.0645 | No | ||
34 | STRN | 5570706 7050333 | 5577 | 0.145 | -0.0677 | No | ||
35 | ADORA2B | 6860253 | 5866 | 0.126 | -0.0822 | No | ||
36 | RAPGEF5 | 1500603 3450427 6130056 | 5909 | 0.124 | -0.0835 | No | ||
37 | RABGAP1L | 3190014 6860088 | 5996 | 0.120 | -0.0871 | No | ||
38 | CREB3L2 | 3390484 | 6004 | 0.119 | -0.0865 | No | ||
39 | ZNF318 | 5890091 6130021 | 6181 | 0.110 | -0.0952 | No | ||
40 | MAP3K5 | 6020041 6380162 | 6661 | 0.089 | -0.1204 | No | ||
41 | GNE | 6100465 | 6827 | 0.083 | -0.1287 | No | ||
42 | MTM1 | 3060112 3170161 | 6909 | 0.079 | -0.1324 | No | ||
43 | TUBGCP3 | 4920563 | 7041 | 0.075 | -0.1389 | No | ||
44 | RNF13 | 2370021 | 7098 | 0.073 | -0.1413 | No | ||
45 | PAFAH1B1 | 4230333 6420121 6450066 | 7219 | 0.070 | -0.1472 | No | ||
46 | LPHN2 | 4480010 | 7442 | 0.063 | -0.1587 | No | ||
47 | CPEB3 | 3940164 | 7648 | 0.058 | -0.1694 | No | ||
48 | BRD8 | 1170463 2900075 4050397 6590332 | 7774 | 0.055 | -0.1757 | No | ||
49 | NPAS2 | 770670 | 7791 | 0.054 | -0.1761 | No | ||
50 | ARHGEF7 | 1690441 | 7815 | 0.054 | -0.1769 | No | ||
51 | NRIP1 | 3190039 | 8067 | 0.048 | -0.1901 | No | ||
52 | LPP | 1660541 | 8155 | 0.046 | -0.1945 | No | ||
53 | MEIS1 | 1400575 | 8223 | 0.044 | -0.1977 | No | ||
54 | CBLB | 3520465 4670348 | 8227 | 0.044 | -0.1975 | No | ||
55 | RRS1 | 4560551 | 8283 | 0.043 | -0.2001 | No | ||
56 | POGZ | 870348 7040286 | 8639 | 0.036 | -0.2191 | No | ||
57 | WDFY3 | 3610041 4560333 4570273 | 8643 | 0.036 | -0.2190 | No | ||
58 | NCK1 | 6200575 6510050 | 8777 | 0.033 | -0.2259 | No | ||
59 | KIF2A | 3990286 6130575 | 8816 | 0.032 | -0.2277 | No | ||
60 | SKAP2 | 6760500 | 9032 | 0.028 | -0.2391 | No | ||
61 | TIPARP | 50397 | 9093 | 0.027 | -0.2422 | No | ||
62 | KIF11 | 5390139 | 9245 | 0.025 | -0.2501 | No | ||
63 | BDKRB2 | 4780706 | 9273 | 0.024 | -0.2514 | No | ||
64 | ZCCHC14 | 5900288 | 9387 | 0.022 | -0.2573 | No | ||
65 | POLE2 | 6110041 | 9434 | 0.021 | -0.2597 | No | ||
66 | SERTAD2 | 2810673 6840450 | 9604 | 0.019 | -0.2687 | No | ||
67 | PLEKHC1 | 2650066 | 9777 | 0.015 | -0.2779 | No | ||
68 | SLC7A1 | 2450193 2710241 | 9925 | 0.013 | -0.2857 | No | ||
69 | MTUS1 | 780348 4920609 | 9973 | 0.012 | -0.2882 | No | ||
70 | BTBD3 | 1980041 2510577 3190053 4200746 | 9984 | 0.012 | -0.2886 | No | ||
71 | XPO1 | 540707 | 10863 | -0.002 | -0.3362 | No | ||
72 | SP3 | 3840338 | 10973 | -0.004 | -0.3421 | No | ||
73 | WDR37 | 2630519 6840347 | 10996 | -0.004 | -0.3433 | No | ||
74 | MTMR6 | 4810520 | 11152 | -0.007 | -0.3516 | No | ||
75 | SMAD7 | 430377 | 11203 | -0.008 | -0.3543 | No | ||
76 | IRS1 | 1190204 | 11519 | -0.013 | -0.3712 | No | ||
77 | VEGFC | 5910494 | 11571 | -0.014 | -0.3739 | No | ||
78 | PUM2 | 4200441 5910446 | 11603 | -0.015 | -0.3754 | No | ||
79 | ZCCHC11 | 3390731 5360039 | 11779 | -0.018 | -0.3848 | No | ||
80 | CENPC1 | 610273 | 11790 | -0.018 | -0.3852 | No | ||
81 | PTPN3 | 870369 | 11819 | -0.019 | -0.3865 | No | ||
82 | MYST4 | 1400563 2570687 3360458 6840402 | 11924 | -0.021 | -0.3920 | No | ||
83 | CENPF | 5050088 | 11951 | -0.022 | -0.3932 | No | ||
84 | TTC9 | 460463 | 12103 | -0.025 | -0.4012 | No | ||
85 | MYC | 380541 4670170 | 12234 | -0.028 | -0.4080 | No | ||
86 | E2F5 | 5860575 | 12364 | -0.031 | -0.4148 | No | ||
87 | NUP153 | 7000452 | 12531 | -0.035 | -0.4235 | No | ||
88 | SPEN | 2060041 | 12625 | -0.037 | -0.4282 | No | ||
89 | MTIF2 | 2260270 | 12648 | -0.038 | -0.4291 | No | ||
90 | ATRX | 2340039 3610132 4210373 | 12753 | -0.041 | -0.4344 | No | ||
91 | NR2F2 | 3170609 3310577 | 12988 | -0.048 | -0.4467 | No | ||
92 | CCNB2 | 6510528 | 13046 | -0.050 | -0.4494 | No | ||
93 | PIP5K2B | 6520156 6620541 | 13184 | -0.055 | -0.4563 | No | ||
94 | IRAK1BP1 | 610037 | 13376 | -0.062 | -0.4662 | No | ||
95 | GCLC | 2810731 | 13481 | -0.067 | -0.4713 | No | ||
96 | FGFR2 | 4670601 5570402 6940377 | 13521 | -0.069 | -0.4728 | No | ||
97 | SLBP | 6220601 | 13541 | -0.069 | -0.4732 | No | ||
98 | PRSS12 | 1230364 6220059 | 13561 | -0.070 | -0.4737 | No | ||
99 | BCAR3 | 1660717 | 13628 | -0.073 | -0.4767 | No | ||
100 | HMGA2 | 2940121 3390647 5130279 6400136 | 13670 | -0.076 | -0.4783 | No | ||
101 | EFNB2 | 5340136 | 13710 | -0.077 | -0.4797 | No | ||
102 | PIP5K3 | 5360112 | 13791 | -0.082 | -0.4834 | No | ||
103 | PIK3R4 | 1990132 | 13835 | -0.084 | -0.4850 | No | ||
104 | E2F3 | 50162 460180 | 13868 | -0.086 | -0.4860 | No | ||
105 | PPP1R3C | 2640170 | 13870 | -0.086 | -0.4854 | No | ||
106 | RSBN1 | 7000487 | 13951 | -0.091 | -0.4889 | No | ||
107 | TBC1D8 | 2340253 | 14153 | -0.105 | -0.4990 | No | ||
108 | PHLPP | 3440563 | 14257 | -0.114 | -0.5036 | No | ||
109 | THRAP2 | 4920600 | 14483 | -0.134 | -0.5147 | No | ||
110 | CDKN1B | 3800025 6450044 | 14572 | -0.142 | -0.5183 | No | ||
111 | ORC2L | 1990470 6510019 | 14587 | -0.144 | -0.5178 | No | ||
112 | LASS6 | 5890576 6520138 | 14625 | -0.149 | -0.5186 | No | ||
113 | WEE1 | 3390070 | 14732 | -0.160 | -0.5230 | No | ||
114 | TLE4 | 1450064 1500519 | 14863 | -0.181 | -0.5286 | No | ||
115 | ZZZ3 | 780133 2320239 2640452 5080706 6550341 | 14952 | -0.194 | -0.5317 | No | ||
116 | PPRC1 | 1740441 | 14966 | -0.198 | -0.5308 | No | ||
117 | SLC9A6 | 4570091 7100097 | 15061 | -0.212 | -0.5341 | No | ||
118 | NPAT | 3800594 4670026 | 15073 | -0.214 | -0.5329 | No | ||
119 | CLASP1 | 6860279 | 15087 | -0.218 | -0.5318 | No | ||
120 | FNDC3A | 2690097 3290044 | 15178 | -0.236 | -0.5347 | No | ||
121 | NCOA3 | 4540195 | 15312 | -0.265 | -0.5397 | No | ||
122 | CTBP2 | 430309 3710079 | 15405 | -0.285 | -0.5423 | No | ||
123 | DTX2 | 4210041 7000008 | 15512 | -0.312 | -0.5455 | No | ||
124 | ADCY9 | 5690168 | 15548 | -0.321 | -0.5447 | No | ||
125 | PCF11 | 1240180 | 15652 | -0.353 | -0.5473 | No | ||
126 | ATF2 | 2260348 2480441 | 15819 | -0.409 | -0.5529 | No | ||
127 | DYRK1A | 3190181 | 15866 | -0.423 | -0.5519 | No | ||
128 | ZHX2 | 2900452 | 15981 | -0.461 | -0.5542 | No | ||
129 | RCHY1 | 3800739 | 16134 | -0.512 | -0.5582 | Yes | ||
130 | SMC4 | 5910240 | 16168 | -0.524 | -0.5556 | Yes | ||
131 | PPP1R12A | 4070066 4590162 | 16212 | -0.543 | -0.5534 | Yes | ||
132 | FOXO1A | 3120670 | 16243 | -0.553 | -0.5504 | Yes | ||
133 | ZNF148 | 6420403 | 16444 | -0.635 | -0.5559 | Yes | ||
134 | CNOT4 | 2320242 6760706 | 16547 | -0.685 | -0.5557 | Yes | ||
135 | KLF9 | 3840022 | 16607 | -0.722 | -0.5529 | Yes | ||
136 | BIRC2 | 2940435 4730020 | 16663 | -0.757 | -0.5496 | Yes | ||
137 | ABL1 | 1050593 2030050 4010114 | 16718 | -0.789 | -0.5459 | Yes | ||
138 | CENPA | 5080154 | 16744 | -0.803 | -0.5406 | Yes | ||
139 | KEAP1 | 1570121 2900546 3840576 | 16747 | -0.805 | -0.5339 | Yes | ||
140 | INSIG2 | 3840603 5700605 6450451 | 16970 | -0.944 | -0.5381 | Yes | ||
141 | ARID3A | 6520605 | 17104 | -1.006 | -0.5369 | Yes | ||
142 | DMTF1 | 5910047 1570497 2480100 6620239 | 17122 | -1.016 | -0.5293 | Yes | ||
143 | REV3L | 1090717 | 17192 | -1.054 | -0.5243 | Yes | ||
144 | EIF2C2 | 770451 | 17196 | -1.057 | -0.5156 | Yes | ||
145 | CREBBP | 5690035 7040050 | 17238 | -1.091 | -0.5087 | Yes | ||
146 | AURKA | 780537 | 17299 | -1.140 | -0.5024 | Yes | ||
147 | CASP8 | 4850154 | 17331 | -1.166 | -0.4944 | Yes | ||
148 | KBTBD2 | 2320014 | 17441 | -1.261 | -0.4898 | Yes | ||
149 | BCL7A | 4560095 | 17468 | -1.282 | -0.4805 | Yes | ||
150 | TAF11 | 5720538 | 17488 | -1.306 | -0.4706 | Yes | ||
151 | SFRS2IP | 730687 1500373 | 17499 | -1.317 | -0.4601 | Yes | ||
152 | USP6NL | 2940068 | 17585 | -1.400 | -0.4530 | Yes | ||
153 | KLF7 | 50390 | 17587 | -1.403 | -0.4414 | Yes | ||
154 | KIF23 | 5570112 | 17597 | -1.409 | -0.4301 | Yes | ||
155 | PTK2 | 1780148 | 17646 | -1.461 | -0.4205 | Yes | ||
156 | PRKCD | 770592 | 17702 | -1.525 | -0.4107 | Yes | ||
157 | TOP2A | 360717 | 17707 | -1.531 | -0.3982 | Yes | ||
158 | CHD1 | 4590048 | 17736 | -1.565 | -0.3866 | Yes | ||
159 | MECP2 | 1940450 | 17781 | -1.615 | -0.3755 | Yes | ||
160 | CUL1 | 1990632 | 17844 | -1.677 | -0.3648 | Yes | ||
161 | SPOP | 450035 | 17876 | -1.710 | -0.3522 | Yes | ||
162 | DIDO1 | 1500601 | 17890 | -1.717 | -0.3386 | Yes | ||
163 | TLK2 | 1170161 | 17903 | -1.733 | -0.3248 | Yes | ||
164 | WDHD1 | 3450390 | 17924 | -1.755 | -0.3112 | Yes | ||
165 | XPA | 6660133 | 17941 | -1.776 | -0.2972 | Yes | ||
166 | ZBTB24 | 4570504 | 17981 | -1.825 | -0.2841 | Yes | ||
167 | FEM1B | 1230110 | 17994 | -1.837 | -0.2694 | Yes | ||
168 | TLK1 | 7100605 | 18049 | -1.887 | -0.2566 | Yes | ||
169 | POLD3 | 6400278 | 18063 | -1.899 | -0.2414 | Yes | ||
170 | TNFAIP8 | 2760551 | 18112 | -1.986 | -0.2274 | Yes | ||
171 | ZNF638 | 6510112 | 18122 | -1.998 | -0.2112 | Yes | ||
172 | SMC5 | 3440164 | 18179 | -2.080 | -0.1969 | Yes | ||
173 | POLS | 5890438 | 18192 | -2.095 | -0.1800 | Yes | ||
174 | UBL3 | 6450458 | 18289 | -2.259 | -0.1664 | Yes | ||
175 | ZBED4 | 770441 | 18373 | -2.450 | -0.1504 | Yes | ||
176 | PIK3C3 | 6590717 | 18390 | -2.492 | -0.1304 | Yes | ||
177 | CTCF | 5340017 | 18444 | -2.618 | -0.1114 | Yes | ||
178 | UBE2G1 | 2230546 5420528 7040463 | 18555 | -3.099 | -0.0915 | Yes | ||
179 | ELF1 | 4780450 | 18577 | -3.453 | -0.0638 | Yes | ||
180 | APPBP2 | 5130215 | 18579 | -3.469 | -0.0349 | Yes | ||
181 | SMAD5 | 5700497 | 18612 | -4.407 | 0.0002 | Yes |