Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Set_03_truncNotch_versus_wtNotch.phenotype_truncNotch_versus_wtNotch.cls #truncNotch_versus_wtNotch |
| Phenotype | phenotype_truncNotch_versus_wtNotch.cls#truncNotch_versus_wtNotch |
| Upregulated in class | wtNotch |
| GeneSet | REACTOME_DNA_REPLICATION |
| Enrichment Score (ES) | -0.6026805 |
| Normalized Enrichment Score (NES) | -1.6718681 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.20105296 |
| FWER p-Value | 0.675 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | PSMD2 | 4670706 5050364 | 941 | 1.679 | -0.0235 | No | ||
| 2 | PSMA1 | 380059 2760195 | 1149 | 1.500 | -0.0104 | No | ||
| 3 | PSMC1 | 6350538 | 1283 | 1.414 | 0.0054 | No | ||
| 4 | PSMD9 | 50020 5890368 | 1407 | 1.336 | 0.0204 | No | ||
| 5 | RFC5 | 3800452 6020091 | 1531 | 1.251 | 0.0340 | No | ||
| 6 | POLD1 | 4830026 | 1795 | 1.079 | 0.0373 | No | ||
| 7 | PSMA7 | 2230131 | 2006 | 0.993 | 0.0421 | No | ||
| 8 | LIG1 | 1980438 4540112 5570609 | 2526 | 0.754 | 0.0263 | No | ||
| 9 | PSMB6 | 2690711 | 2861 | 0.612 | 0.0182 | No | ||
| 10 | PSMB10 | 630504 6510039 | 2884 | 0.604 | 0.0269 | No | ||
| 11 | POLD2 | 6400148 | 3283 | 0.469 | 0.0130 | No | ||
| 12 | MCM2 | 5050139 | 3319 | 0.459 | 0.0185 | No | ||
| 13 | MCM5 | 2680647 | 3531 | 0.411 | 0.0138 | No | ||
| 14 | PSMB3 | 4280594 | 3764 | 0.359 | 0.0071 | No | ||
| 15 | PSMA5 | 5390537 | 4404 | 0.258 | -0.0231 | No | ||
| 16 | POLA2 | 940519 | 4916 | 0.200 | -0.0474 | No | ||
| 17 | MCM3 | 5570068 | 5213 | 0.172 | -0.0606 | No | ||
| 18 | PSMB4 | 520402 | 5847 | 0.127 | -0.0927 | No | ||
| 19 | RFC3 | 1980600 | 7145 | 0.072 | -0.1614 | No | ||
| 20 | PSMB9 | 6980471 | 7156 | 0.072 | -0.1608 | No | ||
| 21 | PSMA3 | 5900047 7040161 | 8176 | 0.045 | -0.2150 | No | ||
| 22 | PSMC3 | 2480184 | 8367 | 0.041 | -0.2246 | No | ||
| 23 | PSMD5 | 3940139 4570041 | 8769 | 0.033 | -0.2457 | No | ||
| 24 | POLE2 | 6110041 | 9434 | 0.021 | -0.2811 | No | ||
| 25 | POLA1 | 4760541 | 9609 | 0.018 | -0.2902 | No | ||
| 26 | PSMA6 | 50609 | 10307 | 0.006 | -0.3277 | No | ||
| 27 | PSMD8 | 630142 | 11013 | -0.005 | -0.3656 | No | ||
| 28 | PSMB5 | 6290242 | 13050 | -0.050 | -0.4746 | No | ||
| 29 | MCM10 | 4920632 | 13362 | -0.062 | -0.4903 | No | ||
| 30 | PSMD11 | 2340538 6510053 | 13588 | -0.072 | -0.5013 | No | ||
| 31 | PSMC2 | 7040010 | 14507 | -0.135 | -0.5486 | No | ||
| 32 | ORC2L | 1990470 6510019 | 14587 | -0.144 | -0.5505 | No | ||
| 33 | ORC1L | 2370328 6110390 | 15143 | -0.230 | -0.5767 | No | ||
| 34 | RPA2 | 2760301 5420195 | 15395 | -0.283 | -0.5857 | No | ||
| 35 | CDK2 | 130484 2260301 4010088 5050110 | 15400 | -0.284 | -0.5813 | No | ||
| 36 | FEN1 | 1770541 | 15480 | -0.302 | -0.5807 | No | ||
| 37 | PSMB2 | 940035 4210324 | 15519 | -0.313 | -0.5776 | No | ||
| 38 | PSMB1 | 2940402 | 15530 | -0.317 | -0.5730 | No | ||
| 39 | ORC4L | 4230538 5550288 | 16081 | -0.494 | -0.5947 | Yes | ||
| 40 | PSME3 | 2810537 | 16141 | -0.515 | -0.5895 | Yes | ||
| 41 | PSMC4 | 580050 1580025 | 16153 | -0.518 | -0.5817 | Yes | ||
| 42 | PSMC6 | 2810021 | 16260 | -0.560 | -0.5784 | Yes | ||
| 43 | MCM7 | 3290292 5220056 | 16282 | -0.569 | -0.5703 | Yes | ||
| 44 | PSMC5 | 2760315 6550021 | 16473 | -0.650 | -0.5700 | Yes | ||
| 45 | E2F2 | 5270609 5570377 7000465 | 16494 | -0.660 | -0.5604 | Yes | ||
| 46 | CDC45L | 70537 3130114 | 16566 | -0.690 | -0.5530 | Yes | ||
| 47 | PSMD3 | 1400647 | 16762 | -0.811 | -0.5504 | Yes | ||
| 48 | PSME1 | 450193 4480035 | 16780 | -0.823 | -0.5380 | Yes | ||
| 49 | MCM6 | 60092 540181 6510110 | 16794 | -0.831 | -0.5252 | Yes | ||
| 50 | GMNN | 2630148 | 16925 | -0.916 | -0.5174 | Yes | ||
| 51 | PRIM1 | 6420746 | 17077 | -0.999 | -0.5093 | Yes | ||
| 52 | PSMD4 | 430068 | 17380 | -1.214 | -0.5059 | Yes | ||
| 53 | ORC5L | 1940133 1940711 | 17603 | -1.414 | -0.4950 | Yes | ||
| 54 | MCM4 | 2760673 5420711 | 17712 | -1.538 | -0.4759 | Yes | ||
| 55 | PSMD10 | 520494 1170576 3830050 | 17774 | -1.611 | -0.4531 | Yes | ||
| 56 | RPA3 | 5700136 | 17795 | -1.631 | -0.4277 | Yes | ||
| 57 | CDC7 | 4060546 4850041 | 17891 | -1.718 | -0.4050 | Yes | ||
| 58 | RFC1 | 1190673 | 17986 | -1.828 | -0.3804 | Yes | ||
| 59 | POLD3 | 6400278 | 18063 | -1.899 | -0.3537 | Yes | ||
| 60 | PCNA | 940754 | 18090 | -1.941 | -0.3237 | Yes | ||
| 61 | PSMD12 | 730044 | 18128 | -2.007 | -0.2932 | Yes | ||
| 62 | RB1 | 5900338 | 18226 | -2.152 | -0.2635 | Yes | ||
| 63 | RPA1 | 360452 | 18231 | -2.159 | -0.2287 | Yes | ||
| 64 | PSMA2 | 6510093 | 18263 | -2.215 | -0.1945 | Yes | ||
| 65 | PSMD7 | 2030619 6220594 | 18323 | -2.337 | -0.1598 | Yes | ||
| 66 | POLE | 6020538 | 18351 | -2.398 | -0.1224 | Yes | ||
| 67 | PSMA4 | 4560427 | 18418 | -2.539 | -0.0848 | Yes | ||
| 68 | PSMD14 | 5690593 | 18497 | -2.806 | -0.0436 | Yes | ||
| 69 | RFC4 | 3800082 6840142 | 18552 | -3.081 | 0.0035 | Yes |
