S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation ADI1 APIP MRI1 KYAT1 ENOPH1 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III MPST GOT1-1 CISD1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) GAD1 GAD2 GLUL ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II CYP2A13;CYP2A6;CYP2A7-1 CYP19A1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) FADS2 ELOVL5 EHHADH-1 ELOVL2 HSD17B12 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation ACAT2 ACAT1 GCDH ECHS1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis ASNS PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation ALDH3A2 PECR MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II UBIAD1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP1 IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5D ITPKA INPP5J INPP5K L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) CBS;CBSL CTH SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NTPCR NME5 TYMS DHODH NME1 NME6 RRM2B NME7 CMPK1 CMPK2 UMPS RRM2-1 RRM1 DUT DTYMK NME4-1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis GPHN SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis TPH2 DDC TPH1 AANAT ASMT ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis NSDHL HSD17B7 LBR TM7SF2 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis SLC27A2 ACSBG2 FADS2 ACSM3 ACSL1 ACSM5 ACSBG1 ACSM4 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II RNGTT RNMT CMTR1 CMTR2 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) IDI1 ACAT2 MVK ACAT1 GGPS1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 FDPS L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation GLS2 GLS L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation GSTZ1 HGD TAT FAH HPD NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation ADH4 ADH1C;ADH1B;ADH1A LRTOMT ALDH3A2 ALDH2 MAOB MAOA COMT PNMT N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II NAGK GNPDA1 GNPDA2 AMDHD2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation HAL MTHFD1 UROC1 AMDHD1 FTCD NADH REPAIR%BIOCYC%PWY-6938 NADH repair GAPDH-1 NAXE NAXD URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) DPYS DPYD UPB1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds PI4K2B MTMR14 PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PLCZ1 PPIP5K1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C IPMK INPPL1 SACM1L PTEN ITPK1 OCRL PLCB3 PLCB4 SYNJ2 PIK3CA INPP5B ITPKB PIK3C3 ITPKC PLCB1 MINPP1 PLCB2 PI4K2A INPP5A IPPK MTMR3 SYNJ1 PIK3R4 PIK3R3 PIK3R2 PIK3R1 INPP5D ITPKA PIK3R6 PIK3R5 INPP5J PLCG2 INPP5K PIP5K1A PIP5K1B PIP5K1C PLCG1 IP6K1 CDIPT IP6K3 IP6K2 FIG4 PIKFYVE PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation ALDH4A1 PRODH;LOC102724788 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I GLO1 HAGH L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation GPT GPT2 ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX SAT2 SAT1 PAOX L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis PAH ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing SLC27A4 CERS3 TGM1 ALOX12B CYP4F22 ALOXE3 PNPLA1 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis CARNS1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis CAD DHODH UMPS GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation GDA NT5C2 PNP-1 XDH SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation CAT SOD2 SOD3 SOD1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis IMPA1 IMPA2 ISYNA1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) UQCRC1 NDUFS2 NDUFS1 UQCRC2 NDUFB9 NDUFB8 NDUFB7 UQCRB NDUFB10 NDUFB6 NDUFB11 NDUFB5 NDUFB4 NDUFB3 NDUFA4L2 NDUFB2 NDUFB1 UQCR11 COX7A2 UQCR10 COX5B COX5A NDUFC2;NDUFC2-KCTD14 CYC1 NDUFV3 NDUFV2 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA4 NDUFA3 COX6C UQCRQ NDUFAB1 NDUFS5-1 COX7B NDUFA13 NDUFA11 NDUFA12 COX4I1 NDUFA10 COX6A1 COX7C UQCRFS1 COX8A SDHC NDUFC1 SDHD SDHA SDHB COX6B1 NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis NUS1 DHRSX SRD5A3 DOLK DHDDS PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 AK1 AK2 GMPS AK3 AK5 PFAS AK7 AK8 ATIC GUK1 PPAT AK4-1 ADSL PAICS IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 GART NME4-1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) NMRK1 NMNAT3 NMNAT2 NMNAT1 NMRK2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt ALDH5A1 GAD1 GAD2 ABAT GLUL GLUD1;GLUD2 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD PGLS PGD UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) UBIAD1 COQ3 COQ2 PDSS2 PDSS1 COQ7 COQ6 COQ5 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis NME2 NME3 NME5 NME1 NME6 RRM2B NME7 GMPS RRM2-1 GUK1 IMPDH1 IMPDH2 RRM1 NME4-1 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis VPS29 PSAT1 SHMT2 SHMT1 PHGDH PSPH PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage NME2 NME3 GUK1 DGUOK NME5 DCK NME1 NME6 NME7 NME4-1 AK5 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 DIO1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation ASNS GLS2 GLS VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle VKORC1 NQO1 VKORC1L1 GGCX MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation PNP-1 ADA GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I GGT5 GSTM3 GSTK1 GSTO2 GSTP1 MGST3 NAT8-2 MGST1 MGST2 GSTT1 GSTT2B;GSTT2 GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA4 ANPEP GSTA3;GSTA5;GSTA1;GSTA2 GSTZ1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate MTHFD1 GART ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis LTA4H PTGS2-2 ALOX5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I AZIN2 AGMAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II CHKB PCYT2 ETNK2 ETNK1 CEPT1 SELENOI CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CARNS1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 DTYMK CMPK2 NME4-1 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis GPX4 ALOX15 ALOX12 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) AADAT PYCR1 PIPOX CRYM DHTKD1 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) HYAL1 HYAL4 SPAM1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis TYR ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis ATP6V1A ATPAF2-2 ATP5MC2 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B ATP6V1H ATP6V1E1 ATP6V1D ATP5MG ATP6V1C1 ATP6V1F ATP5ME ATP6V0A1 ATP5PF ATP6V1G1 ATP6V0B VPS9D1 ATP5PD ATP5PB ATP5F1C ATP5F1D ATP6V0E2;ATP6V0E1 ATP6V1B2 ATP5PO ATP6V0D1 ATP6V0C ATPAF1 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation SHMT2 SHMT1 MTHFD1 MTHFD1L FPGS L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis VPS29 PSAT1 PHGDH PSPH L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I ASRGL1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I ACOD1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis PFAS PPAT GART PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I CDA UCK1 UCKL1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis ACAT2 SQLE ACAT1 EBP KCNH7 SC5D DHCR24 DHCR7 LSS FDFT1 HMGCS1-1 FDPS IDI1 MVK GGPS1 IDI2 PMVK MVD HMGCR NSDHL HMGCS2 HSD17B7 LBR TM7SF2 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III ARG2 ODC1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation CDA UPP1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HMGCS2 HMGCL BDH2 BDH1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation DCXR AKR1A1 CRYL1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PI4KA PLCH1 PLCH2 PI4KB PLCD3 PLCD4 PLCD1 PI4K2B PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CAT CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) CYP2E1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation DBT ACAT2 BCKDHB ACAT1 BCAT1 DLD ACADSB HSD17B10 BCAT2 BCKDHA ECHS1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis AGXT2 AGXT ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) FADS2 ELOVL7 FADS1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B4GALT2 B4GALT3 B4GALT1 FUT2 FUT1 UGCG B3GALT1 ST3GAL4 ST3GAL5 B4GALNT1 ST3GAL6 A4GALT ST3GAL2 ST3GAL3 B3GALNT1 ST6GAL1 ST8SIA1 ST8SIA2 ST8SIA3 B3GALT4 B3GALT5 GBGT1 B3GNT5 B3GNT2 B4GALT6 B4GALT4 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I HMOX1 BLVRA HMOX2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B3GNT5 B3GNT2 B4GALT6 B4GALT4 B4GALT2 B4GALT3 B4GALT1 UGCG ST3GAL4 ST3GAL6 ST6GAL1 ST8SIA2 ST8SIA3 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III TPK1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation DPYS DPYD UPB1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation MTAP NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation NNT NADK CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation CHDH ALDH7A1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI ADK PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis PCYT1B PCYT1A PEDS1-UBE2V1;PEDS1 CHKA AGPAT1 GNPAT AGPS CHKB FAR1 PCYT2 FAR2 ETNK2 ETNK1 CEPT1 SELENOI L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis TYR L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) TDO2 KYNU AFMID KYAT3 ALDH8A1 IDO2 IDO1 AADAT DHTKD1 KYAT1 GOT2-1 HAAO KMO ACMSD ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) CYP2A13;CYP2A6;CYP2A7-1 HSD17B1 CYP19A1 HSD17B3 HSD17B7 HSD17B11 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation SUOX HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis HDC GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis UGCG ST3GAL5 B4GALT6 B4GALNT1 ST3GAL2 ST3GAL3 ST6GAL1 ST8SIA1 B3GALT4 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3GALT1 ST3GAL3 FUT6;FUT5;FUT3 FUT2 B3GALT5 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III AKR1B15;AKR1B10 AKR1B1 CYP2E1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT1A MAT2B MAT2A PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation TMEM86B ENPP2 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis CAD NME2 CTPS2 NME3 CTPS1 NME5 DHODH NME1 NME6 NME7 CMPK1 CMPK2 UMPS NME4-1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) IPPK IPMK ITPK1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis SHMT2 SHMT1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis SCD FADS6 SCD5 ACOT2;ACOT1 ACOT4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis TBXAS1 PTGDS PTGR1-1 CBR1-1 PTGES PTGS2-2 PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation TPTE;TPTE2 INPP4A INPP4B SACM1L INPPL1 INPP5E PTEN OCRL SYNJ2 INPP5B MTMR3 SYNJ1 INPP5F INPP5D MTMR14 INPP5J INPP5K PIP4P2 PIP4P1 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis ELOVL4 TECR HSD17B12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) PPCS COASY PPCDC RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis GPX4 ALOX5 ALOX15 ALOX12 EPHX3 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2E1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis PTGES3-1 PTGIS HPGD PTGES2 PTGR2 PTGS1 HPGDS TBXAS1 PTGDS PTGR1-1 PTGES GGT5 GSTM4 GPX4 ALOX5 ALOX15 DPEP1 ALOX12 LTC4S EPHX3 CYP2J2-1 CYP2D6;LOC107987479;LOC107987478-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ALOX15B DPEP2 LTA4H PTGS2-2 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination PADI6 PADI3 PADI2 PADI4 PADI1 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) PAH PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II PTDSS2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK INPPL1 PTEN OCRL SYNJ2 INPP5B ITPKB ITPKC MINPP1 INPP5A SYNJ1 INPP5D ITPKA INPP5J INPP5K INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis IP6K3 IPPK PPIP5K1 IP6K2 PPIP5K2 IPMK IP6K1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism DIO1 DIO3 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway TXNRD3 TXNRD2 TXNRD1 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis PTGS2-2 ALOX5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate ACLY KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 BDH2 BDH1 OXCT1-1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation ALDH3B2;ALDH3B1 ALDH1B1 PGM2 DERA ALDH3A1 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation ALOX5 ALOX15 ALOX12 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine BHMT BHMT2 MTR-1 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation CYP4X1 CYP2C9;CYP2C19 CYP2U1 CYP2S1 CYP1A2 MAOA CYP1B1 CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 POR 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ALDH8A1 DHTKD1 ACMSD GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions GPX1 GPX4 GSR GPX7 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage NMNAT3 NMNAT2 NAMPT NMNAT1 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation AOC1 HNMT CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis CDS1 MBOAT7 MBOAT1 MBOAT2 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM AGPAT1 LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 CDS2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt BPGM MINPP1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III HACL1 ALDH3A2 FA2H GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis GPI TPI1 MDH1 MDH2 PGAM1 PGAM2 ENO1 ENO2 ENO3 G6PC1 G6PC2 G6PC3 PC GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PCK1 FBP1 FBP2 BPGM PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I ALDH3A2 ALDH2 AOC3 MAOB MAOA AOC2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) RPIA RPE;RPEL1 TALDO1 TKT VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II ELOVL7 TECR ELOVL1 HSD17B12 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) SLC27A2 ACSBG2 FADS2 ELOVL5 ELOVL7 FADS1 ACSM3 ACSL1 HSD17B12 ACSM5 ACSBG1 ACSM4 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle OPLAH CNDP2 GGT5 GGCT GCLC GSS GCLM UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I CTPS2 CTPS1 NTPCR GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis HK3 PGM2 PYGB MGAM HKDC1 PYGM PYGL PGM1 HK2 GCK HK1 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation DBT BCKDHB BCAT1 DLD ABAT BCAT2 ACAD8 ALDH6A1 HIBADH BCKDHA ECHS1 HIBCH ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) ATE1 NAA20 NAA25 NTAQ1 APEH NTAN1 METAP1 METAP2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis PTGS2-2 ALOX5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis GOT1-1 GOT1L1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II HK3 PGM2 HKDC1 PGM1 HK2 GCK HK1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II MAOA TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II TSEN2 C2orf49 TSEN54 RTRAF TSEN34 TSEN15 DDX1 RTCB ZBTB8OS FAM98B PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage CDA TK2 TK1 TYMS DCK PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 RRM2-1 RRM1 DUT DTYMK NME4-1 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis PYCR2 ALDH18A1 PYCR1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA3;GSTA1 GSTA4 GSTA3;GSTA5;GSTA1;GSTA2 GSTP1 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation GDA NT5C2 PNP-1 XDH ADA NT5C3A NT5E IMPDH1 NT5C1A IMPDH2 NT5C1B;NT5C1B-RDH14 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis MAT1A MAT2B CBS;CBSL CTH AHCY MAT2A L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle MAT1A MAT2B ADI1 APIP MTAP MRI1 SRM KYAT1 MAT2A ENOPH1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP1 INPPL1 OCRL SYNJ2 INPP5B INPP5A BPNT2-1 SYNJ1 INPP5F IMPA1 IMPA2 INPP5J INPP5K 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation ACADSB BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway BMP2 ZFYVE16 BMPR2 BMPR1B ACVR2A SKI SMAD4 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis DPEP2 GGT5 LTA4H GSTM4 ALOX5 DPEP1 LTC4S PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis HSD3B1;HSD3B2 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis GLUD1;GLUD2 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II XDH RBP4 RBP5 RBP1 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation ALDH3A2 MAOB MAOA COMT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis ALOX15 ALOX12 EPHX3 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I GOT1-1 GOT1L1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis ST3GAL5 UGT8 GAL3ST1 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I SORD PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate LDHB LDHA;LDHC LDHA PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III ALDH3B2;ALDH3B1 ALDH1B1 ALDH3A2 ALDH2 MAOB MAOA SAT2 SAT1 ALDH3A1 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis CKMT1A;CKMT1B CKM CKB CKMT2 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) QTRT1 QTRT2 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation DBT BCKDHB BCAT1 DLD MCCC2 AUH BCAT2 IVD HMGCL MCCC1 HMGCLL1 BCKDHA GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle GPD1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation ASRGL1 GOT1-1 AGA SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation ADH1C;ADH1B;ADH1A ALDH3A2 ALDH2 MAOA SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis AK7 AK8 AK4-1 ADSL AK1 ADSS1 AK2 ADSS2 AK3 AK5 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis ACOT9 ACOT8 ACOT7 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLAAT1 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde TDO2 KYNU AFMID IDO2 IDO1 HAAO KMO UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis UGDH UXS1 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLA2G1B PLD4 PLA2G3 PLA2G5 PLD6 PLD1 PLA2G6 PLB1 PLA2G2A-1 PLD3 PLD2 PLCZ1 OC90 JMJD7-PLA2G4B;PLA2G4B PLA2G10;LOC100652777 PLCE1 PLA2G2F PLA2G4F PLA2G2D PLA2G12A PLA2G2E PLA2G4D PLA2G4E PLCB3 PNPLA8 PLCB4 PLA2G4A PLCB1 PLCB2 PLCG2 PLCG1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis SQLE FDFT1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis SRD5A2 SRD5A1 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis GOT1-1 GCLC GSS GCLM COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis PANK1 PPCS COASY PPCDC PANK3 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation ALDOC TKFC ALDOB TPI1 SI ALDOA KHK PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis PRPS2 PRPS1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage NME2 NME3 TK2 TK1 NME5 TYMS NME1 NME6 NME7 CMPK1 CMPK2 CDA DCK DTYMK NME4-1 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis PCYT1B PCYT1A CHKA CHPT1 CHKB CEPT1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization TDO2 ADH1C;ADH1B;ADH1A KYNU NMNAT3 AFMID NMNAT2 ALDH2 MAOB ALDH8A1 MAOA IDO2 IDO1 DHTKD1 TPH2 DDC TPH1 AANAT ASMT CYP2A13;CYP2A6;CYP2A7-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GCDH ECHS1 POR ACAT2 CYP4X1 ACAT1 CYP2C9;CYP2C19 CYP2U1 ALDH3A2 CYP2S1 CYP1A2 CYP1B1 QPRT NADSYN1 AKR1A1 HAAO KMO NMNAT1 ACMSD FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) SLC27A2 ACSBG2 HSD17B10 ACOX2 SCP2 EHHADH-1 ACOX1 ACAA1-1 HSD17B4 ACSBG1 HADH ECHS1 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine ALDH3A2 DDC MAOB AKR1A1 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 NARS1 QARS1 NARS2 IARS2 IARS1 VARS2 EARS2 VARS1 RARS2 HARS1 RARS1 MARS2 MARS1 DARS2 HARS2 DARS1 WARS1 WARS2 LARS2 GARS1 SARS1 SARS2 EPRS1 LARS1 TARS2 TARS3 FARSA CARS1 CARS2 TARS1 FARSB AARS1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage PDXK PNPO N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I GNPDA1 GNPDA2 AMDHD2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis TAT SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage NME2 NME3 NME5 NME1 NME6 RRM2B NME7 RRM2-1 PNP-1 ADA APRT HPRT1 AK1 AK2 GMPS AK3 AK5 AK7 ADK AK8 GUK1 AK4-1 ADSL IMPDH1 IMPDH2 ADSS1 RRM1 ADSS2 NME4-1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) SPTLC1 SPTLC3 DEGS1 KDSR CERS1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP NME2 NME3 NTPCR NME5 TYMS NME1 NME6 RRM2B NME7 DCTD RRM2-1 RRM1 DTYMK NME4-1 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis NME2 CTPS2 NME3 CTPS1 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine CHDH ALDH7A1 SHMT2 SHMT1 BHMT DMGDH TCA CYCLE%BIOCYC%PWY66-398 TCA cycle MDH1 DLD MDH2 FH IDH3G DLST CS SUCLA2 SDHC IDH3B OGDH SDHD SUCLG2 SDHA SUCLG1 SDHB ACO2 IDH3A N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis EMG1 TSR3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation ECI1 SLC27A2 ACSBG2 HSD17B10 SCP2 HADHA HADHB-1 ACSBG1 HADH ACAA2 ECHS1 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis SPTLC1 SPTLC3 DEGS1 KDSR CERS1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) ELOVL7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II ADH1C;ADH1B;ADH1A SORD LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis UGCG B3GNT5 B3GALT1 ST3GAL5 B4GALT6 ST6GAL1 FUT2 B3GALT5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation SDSL TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling PCBD1 PCBD2 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis SRM TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis GCH1 SPR PTS L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) ACAT2 TDO2 ACAT1 KYNU AFMID ALDH8A1 IDO2 IDO1 DHTKD1 HAAO GCDH KMO ECHS1 ACMSD PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation OGA OGT-1 CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis HCCS RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I RBP4 RBP5 RBP1 SDR16C5 ALDH1A3 ALDH1A2 ALDH1A1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide ST3GAL4 ST3GAL3 B4GALT2 B4GALT3 ST8SIA2 FUT6;FUT5;FUT3 B4GALT1 FUT9 CHST1 FUT1 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation NME2 NME3 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME4-1 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation CDA DPYS DPYD UPB1 UPP1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) DIO1 DIO3 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) FADS2 ELOVL5 FADS1 ACSM3 ACSL1 ACSM5 ACSM4 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis GCNT2 GCNT3 B3GNT2 B4GALT2 B4GALT3 B4GALT1 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) ECI1 ECI2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis GPI TPI1 HK3 PGAM1 HKDC1 PGAM2 ENO1 ENO2 ENO3 HK2 GCK HK1 GAPDHS PGK1 GAPDH-1 ALDOC ALDOB ALDOA PKLR PFKL PKM PFKM PFKP BPGM HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) CBS;CBSL CTH HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis GCNT3 B3GNT2 B4GALT4 LALBA ST3GAL3 ST6GALNAC6 ST6GAL1 B4GALT2 FUT6;FUT5;FUT3 B4GALT1 FUT2 B3GALT5 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation NT5C2 PNP-1 XDH NT5E IMPDH1 IMPDH2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I FECH UROD CPOX PPOX MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle SLC25A20 CPT1C CPT1B CPT1A CPT2 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis TYR DCT TRPC1 TYRP1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) NDUFAB1 OXSM MCAT ACSF3 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FAAH FAAH2 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis UGCG GBGT1 B4GALT6 A4GALT ST3GAL2 B3GALNT1 FUT2 B3GALT5 FUT1 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation HK3 HK2 GCK HK1 TREH LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis EPHX4 CYP2C9;CYP2C19 EPHX2 EPHX3 EPHX1 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) RDH8 RLBP1 RPE65 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RBP3 RDH11 RDH10 RDH5 LRAT ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis HSD3B1;HSD3B2 HSD17B3 SRD5A2 SRD5A1 CYP17A1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis NME2 NME3 GUK1 NME5 IMPDH1 NME1 NME6 IMPDH2 NME7 GMPS NME4-1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis LIPC BCO1 PNLIP CES2 CES1 RDH8 DHRS3 DHRS4 RBP4 RBP2 RBP5 RDH12 DHRS9 RBP1 RDH11 RDH10 LRAT CES5A DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 GPX4 ALOX5 ALOX15 ALOX12 EPHX3 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 PIP5K1A PIP5K1B PIP5K1C CDIPT UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II GPI HK3 GALE HKDC1 PGM3 GNPNAT1 GNPDA1 UAP1 GNPDA2 HK2 GCK HK1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I ALDH5A1 ABAT CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis HKDC1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I GOT1-1 CDO1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis SLC27A2 ACSBG2 ACOT2;ACOT1 ACOT4 ELOVL7 ELOVL6 ACSL1 HSD17B12 ACOT7 ACSBG1 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation ABAT TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation ALDH4A1 HOGA1 GOT2-1 PRODH2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation CYP4F3;CYP4F2;CYP4F12;CYP4F11 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) FADS2 ELOVL5 ELOVL2 HSD17B12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis LSS SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism SLC27A2 ACSBG2 PTGR1-1 ASAH1 ASAH2 SPHK2 SPHK1 SGPP2 SGPP1 ACER2 ACER1 ACSL1 ACSBG1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate PGM2 PNP-1 ADA PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation CDA TYMP UPP1 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCZ1 PLCE1 PIP4K2A PLCH1 PLCH2 PIP4K2C PLCD3 PLCD4 PLCB3 PLCD1 PLCB4 PLCB1 PLCB2 MTMR3 MTMR14 PLCG2 PLCG1 PIP4P2 PIP4P1 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis SRD5A2 SRD5A1 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis SMS FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I SHMT2 SHMT1 MTR-1 ST20-MTHFS;MTHFS ALDH1L1 MTHFD2 MTHFD2L MTHFR MTHFD1 ALDH1L2 MTHFD1L GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation GK5 GK GK2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation MPI L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation MAT1A MAT2B AHCY MAT2A ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III PNP-1 ADA HPRT1 REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation GPX6 GPX5 GPX8 CAT GPX1 SOD2 SOD3 GPX7 SOD1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation NT5C2 PNP-1 XDH ADA NT5C3A NT5E NT5C1A NT5C1B;NT5C1B-RDH14 ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AKR1B15;AKR1B10 CYP2E1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis SHMT1 TMLHE BBOX1 ALDH9A1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) IPMK INPPL1 ITPK1 OCRL SYNJ2 INPP5B ITPKB ITPKC INPP5A IPPK SYNJ1 INPP5D ITPKA INPP5J INPP5K LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis ALOX15B GPX4 ALOX5 ALOX15 ALOX12 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation LIPC PNPLA2 PNLIP LIPF LIPE DAGLA LIPG PNPLA3 PNPLA4 LPL CEL DAGLB CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis PGS1 PTPMT1 CRLS1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation COMT CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis GAMT GATM UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) UGDH GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis PFKFB2 PFKFB1 TIGAR PFKFB4 PFKFB3 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis GGPS1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) SHMT2 TYMS DHFR2;DHFR ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis RRM2-1 NME2 NME3 NME5 NME1 NME6 RRM2B RRM1 NME7 NME4-1 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT3 NMNAT2 QPRT NADSYN1 NMNAT1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis COX10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I RNGTT RNMT DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis CBR1-1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I PTDSS1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) FADS2 ELOVL5 ELOVL7 ELOVL2 HSD17B12 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) GCNT2 GCNT3 ST6GAL2 ST3GAL4 B3GNT2 ST3GAL3 ST6GAL1 B4GALT2 B4GALT3 ST8SIA2 B4GALT1 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III ACSS3 ACSS2 ALDH3A2 ALDH2 ACSS1 CYP2E1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II ACSS3 ADH1C;ADH1B;ADH1A ACSS2 ALDH3A2 ALDH2 ACSS1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation DBT BCKDHB MCEE DLD PCCA PCCB MMUT BCKDHA LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III GLB1 LCT GLB1L3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 AOX1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FMO2 FMO3 FMO4 FMO5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) GALM-2 GALK1 PGM2 GALE PGM1 GALT UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II GPI HK3 GFPT2 GFPT1 HKDC1 PGM3 GNPNAT1 UAP1 HK2 GCK HK1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis GPT GPT2 INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis ATIC ADSL PAICS L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) ALDH7A1 AASS AADAT DHTKD1 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis SEPSECS SEPHS1 SEPHS2 PSTK SARS1 SARS2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation HACL1 SLC27A2 ALDH3A2 ACSM1 PHYH-4 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis GLUL TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis GGPS1 FDPS THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis TYW1;TYW1B TYW3 LCMT2 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I GDE1 PLAAT2 PLAAT5 ENPP2 PLA2G1B NAPEPLD PLAAT1 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation ACAT2 ACAT1 ACADSB ACSM1 ECHS1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis TDO2 KYNU NMNAT3 AFMID NMNAT2 IDO2 IDO1 QPRT NADSYN1 HAAO NMNAT1 KMO LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation SLC27A2 ACSL3 ACSBG2 ACSL1 ACSBG1 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) TST 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis DDHD1 DAGLA PLCB1 DAGLB ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) N6AMT1 PNP-1 TRMT112 SLC34A2 SLC20A2 SLC20A1 AQP9 SLC2A1 LOC100509620;LOC112267859;AQP7 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation CYP4X1 CYP2U1 CYP2S1 CYP2A13;CYP2A6;CYP2A7-1 CYP2B6 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation ADH5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I PGM2 PGM1 UGP2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis LTA4H PTGS2-2 ALOX5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis ALDH18A1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis GMPPB MPI GPI PMM1 PMM2 GMPPA CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) SQLE EBP KCNH7 SC5D DHCR24 DHCR7 LSS NSDHL FDFT1 HSD17B7 LBR TM7SF2 UREA CYCLE%BIOCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) SHMT2 SHMT1 BHMT DMGDH SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) TST SQOR SUOX HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis ALAD ALAS2 FECH ALAS1 UROD UROS CPOX HMBS PPOX PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I MCEE PCCA PCCB MMUT L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation DBT BCKDHB SDSL DLD SDS BCKDHA GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage PNP-1 HPRT1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle NOS3 NOS1 ASL ASS1 NOS2 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation DBT BCKDHB MCEE DLD BHMT PCCA BHMT2 PCCB MTR-1 MMUT CDO1 SUOX AHCY MAT2A MAT1A GOT1-1 MAT2B CBS;CBSL CTH BCKDHA TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis ALAD ALAS2 ALAS1 UROS HMBS MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway IDI1 ACAT2 MVK ACAT1 IDI2 PMVK MVD HMGCR HMGCS2 HMGCS1-1 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II FMO1 ADO PPCS ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) GSTO1 GLRX DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis MOGAT3 PLPPR2 PLPPR3 MOGAT1 PLPPR4 DGAT2 DGAT1 PLPP4 MBOAT7 PLPP3 MBOAT1 PLPP2 MBOAT2 PLPP1 ABHD5 LCLAT1 AGPAT2 AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 LPCAT3 AGPAT5-1 GPAT3 GPAT2 AGPAT1 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis FLAD1 RFK D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis IPMK ITPK1 MINPP1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis DDC TH DBH PNMT 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis TYW1;TYW1B TYW3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I FMO1 CSAD CDO1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I APRT MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle GOT1-1 MDH1 MDH2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor NCOA1 MAP4K1 FOXO1-1 FOS RHOA PJA1 TGFBR2 NME1 TGFBR3 RBL2 KAT2B PPM1A ZEB2 ZEB1 TFDP1 RBL1 TFDP2 STRAP CRK CD44 ENG ROCK1 HDAC1 LEF1 MAPK8 FZR1 PARD6A STAMBPL1 YAP1-1 MAPK1 E2F5 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 MAPK14 PML SKI FKBP1A EIF3I CTNNB1 FOSB BCAR1 RB1 ATF2 SPARC ZFYVE9 UBE2D1 TGFBR1-1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC CDC27 SNIP1 AKT1 EP300 SOX9 BTRC MAP3K7 TGIF1-1 JUNB VPS39 SKP1 PDK1 NUP214 PRKCG MAP2K3 MEF2A DAXX MEF2C ANAPC7 PRKCB FOXH1 PRKCD RUNX2 CDC25A RBX1 AR EID2 ZFYVE16 PRKAR1B CCNE1 HGS EWSR1 ANAPC4 ANAPC5 TP53 ANAPC1 ATF3 KPNB1 PPP2R2A;PPP2R2D ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 PIK3R1 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SMAD2;SMAD3 SKIL SPTBN1 SNX6 MAP2K6 HSPA8 TRAP1 WWTR1 TGFB2 JUN SMAD4 CREBBP JUND TGFB1 SMURF2 SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 PTK2 SMAD7 DAB2 SNW1 CDK6 COPS5 CDK4 SP1 CDC16 CDK2 CDK1 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 CDKN1A CITED1 ARRB2 CTCF BRCA1 UBE2D3-1 ING2 XPO1 XPO4 SUMO1 HNF4A BDNF%IOB%BDNF BDNF FOXO3 SHC4 NTRK1 NTRK2 GSK3B IRS1 IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 MAPK8 AKT1 SHC1-1 MAPK1 MAPK3 CCR1%IOB%CCR1 CCR1 PXN ZAP70 GNA14 CCL4L2;CCL4L1;CCL4 CCL8 MAPK14 PTK2 CCL5 CCL23;CCL15 CCL3L1;CCL3L3;CCL3;CCL18 CCL16 CCL26 PRKCD PTK2B CCR1 CCL14 STAT1 SRC NFKB1 MAPK1 RELA CREB3 MAPK3 LEPTIN%IOB%LEPTIN Leptin PIK3R2 PIK3R1 KHDRBS1 ITGB5 SLC2A4 EGFR LEPR ITGAV JAK2 JAK3 SOCS7 PRKCE NCOA3 STAT3 RPS6 PTPN11 RPS6KB1 LEP PDE3A GRB2 MAPK1 MAPK3 MAPK14 PTK2 PRKCD SP1 IRS1 IRS2 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin STAT3 FOXO3 SHC1-1 ATXN2L STAT5B MAP2K2;MAP2K1 MAPK1 MPL GAB1 JAK2 MAPK3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor SOCS4 SOCS5 STAT5A LYN YES1 MTOR EPOR KITLG TEC FES ATF2 GRAP IL7R MAD2L1 CRK AKT1 MAPK8 EP300 MAPK1 MAPK14 PRKCB GSK3B PLCG1 RAF1 SHC1-1 STAT1 SRC RELA PIK3R2 PIK3R1 JAK2 JAK3 RPS6 JUN PTPN11 RPS6KB1 GRB2 STAT5B PTPRU SH3KBP1 WIPF1 CLTC CBLB CRKL SPRED2 GYS1 SPRED1 RPS6KA1 HRAS MATK PRKCA MITF FGR HCK DOK1 PIK3CA RASA1 KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SOS1 GRB7 WAS CSF2RB CBL SOCS1 INPP5D EIF4EBP1 ABL1 FYN SOCS6 CCR7%IOB%CCR7 CCR7 FOXO1-1 MAPK14 FOXO3 MTOR CCL21 ADRB2 GSK3B CFL1 CCR7 CCL19 PTK2B PLCG1 RPS6KB1 MAPK8 AKT1 MAPK1 RELA MAPK3 WNT%IOB%WNT Wnt RHOA YES1 GSK3A YWHAB CCND1 PPP2CB;PPP2CA CHD7 DIXDC1 ILK LEF1 PRKACA-1 AKT1 MAPK8 SOX1 CDH1 RAC1 RSPO1 MAP3K7 WNT5A AXIN1 KREMEN1 DKK1 PAX2 SFRP1 PRKCG SFRP2 DAAM1 ARHGEF4 ROR1 ROR2 PI4K2A PRKCB LRP1 CTNNB1 CTBP1 PRKCD LRP5 NLK MESD LRP6 GSK3B FRZB DVL1 DVL2 GPC3 DVL3 PIP5K1B WNT1 WNT2 WNT3 MARK2 WNT4 FZD1 TCF7L2 SMAD1 FZD3 GCKR FZD5 SETDB1 JUP FZD4 CSNK1A1 WNT3A FZD7 FZD6 FZD9 WNT7A FZD8 NFATC2 PPP1CA BCL9 APC PIN1 TCF4 JUN CDK6 PRKCA ARRB2 FAS%IOB%FAS Fas TRAF1 TRAF3 LCK TCP1 TOP1 CSNK2A1;CSNK2A3 MET PLEC PRKN GTF3C3 PARG SATB1 SRF USO1 XIAP GLRX CDC42 CD59 BID PAK2 DEDD ROCK1 EIF4B MBD4 CASP8AP2 DIABLO-1 CFLAR CASP5;CASP4 WEE1 NEDD4 MAPK1 EIF3J BAX MAPK3 FAS PTPN6 PKN2 PKN1 VIM GSK3B MAP2K2;MAP2K1 RASA1 FYN LYN CDC27 AKT1 RAC1 DAXX PRKCD CSNK1A1 PDCD6 CDK11A;CDK11B TIAL1 ARHGDIB MAP3K5 CAST UBE4B PSME3 CSNK2B BTK UBA7 MAX PRKDC STK4 STK3 DEDD2 RIPK1 FADD TIA1 EIF2AK2 BMX EIF2S1 STK24 BCL2 TPTEP2-CSNK1E;CSNK1E BCL2L1 NUMA1 FAF1 HSPB1 FASLG CASP9 CASP7 CASP8 AIFM1 CASP6 CASP10 CASP3 FASTK XPO5 CASP1 CASP2 DFFA RFC1 PARP1 RIPK2 ANXA4 MST1 TRAF2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin RHOA YES1 MTOR MET PLEC YWHAB AKT1 RAC1 VIM YWHAE RTKN ITGB4 PIK3CD LAMC2 LAMC1 PIK3CB PIK3CG PRKCD MYLK3 YWHAQ EPHB2 YWHAH AR IRS1 DSP IRS2 DST RPSA YWHAZ ITGA6 COL17A1 LAMA5 CD151 LAMA2 SHC1-1 LAMA3 PIK3R3 MST1R SRC NTN1 PAK1 ERBB2 CLCA1 SFN EIF4E PIK3R2 LAMB3 PIK3R1 LAMB2 BAD ERBIN LAMB1 EIF6 EGFR SMAD2;SMAD3 PTPN11 GRB2 PTK2 PRKCA PIK3CA CASP3 TP73 EIF4EBP1 ABL1 FYN NGF%IOB%NGF NGF ELK1 PRKCI CREB1 DNAJA3 SP1 FRS2 MAP2K2;MAP2K1 MAPK1 MAPK3 HEDGEHOG%IOB%HEDGEHOG Hedgehog DHH HHIP IHH GLI1 GLI3 GLI2 MED12 SHH CCNB1 GRK2 STK36 BOC PRKACA-1 SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 KIF27 MED6 MED23 CDK8 SMO GAS1 YWHAE CTNNB1 ARRB2 GM-CSF%IOB%GM-CSF GM-CSF STAT5A LYN YES1 TGFBR3 FES GSK3A AKT1 MAPK8 MAPK1 MAPK3 PTPN6 MAP2K3 MAPK14 BCAR1 GSK3B ELK1 MAPK9 PLCG1 RAF1 SHC1-1 STAT1 PXN PIK3R2 PIK3R1 BAD CREB1 JAK2 MAP2K6 STAT3 RPS6KB1 TGFB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 CSF2 SLC2A1 CRKL PARK7 IKBKB DPYSL2 RPS6KA2 RACK1 SPTAN1 PDIA3 PRKCA CHUK SYK VAV1 HCK HNRNPH1 PFN1 EZR STAM2 CSF2RA PRDX3 GANAB CCT5 CSF2RB SH2B2 CBL STAM NFKBIA PTPRC BCL3 CCR9%IOB%CCR9 CCR9 MSN CCR9 FOXO1-1 CD226 ITGB7 MAPK14 MADCAM1 GSK3B EZR RPS6KB1 MAPK8 AKT1 CDH1 CCL25 MAPK1 ITGA4 RDX MAPK3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK STAT5A MAPK14 BMX PTK2 NOS3 TIE1 DOK2 TEK FES NCK1 ELK1 GRB7 RAF1 AKT1 SHC1-1 STAT5B PAK1 MAP2K2;MAP2K1 MAPK1 MAPK3 CCR5%IOB%CCR5 CCR5 CCL4L2;CCL4L1;CCL4 STAT5A PIK3R1 CCL8 CCL5 CCL3L1;CCL3L3;CCL3;CCL18 CCL26 CCL13;CCL2 CCL11 C5AR1 AFP CCR5 CFL1 PSMA5 CD4 STAT3 AKT1 GRB2 MAPK1 MAPK3 PTPN6 MAPK14 IKBKB CHUK SYK PTK2B CCL14 NFKBIA STAT1 RELA IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha ZAP70 STAT5A FOXO1-1 MTOR MAP2K6 RPS6KA5 ERBB3 CRK STAT4 STAT6 STAT3 EIF4B JAK1 RPS6 IFNAR2 MAP2K4 RPS6KB1 AKT1 STAT2 PLA2G4A TYK2 ARHGAP30 STAT5B PRKCQ IFNAR1 MAP2K3 CRKL PRKCD VAV1 IRS1 IRS2 CBL NFKBIA STAT1 EIF4EBP1 TRAIL%IOB%TRAIL TRAIL CSNK2A1;CSNK2A3 CREB1 XIAP BID AKT1 DIABLO-1 CFLAR PRKDC MAP3K7 MAPK1 BEX3 BAX PRKAA1 MAPK3 TRADD RIPK1 TNFRSF11B FADD BCL10 CYCS-1 CHEK2 MAPK14 TNFSF10 IKBKG BAK1 CTSB MCL1 CTNNB1 APAF1 IRF5 ATM VDAC1 DAP3 CASP7 CASP8 AIFM1 CASP10 CASP3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP1 CASP2 CBL NFKBIA PARP1 SRC NFKB1 RELA TRAF2 NOTCH%IOB%NOTCH Notch KAT2B HDAC1 LEF1 EP300 MAPK1 MAPK3 SKP1 RBX1 GSK3B APP MAML2 MAML1 FHL1 RBPJ LFNG YY1 HEY1 POFUT1 SIN3A CCN3 CIR1 SKP2 PSENEN SMAD1 HES6 NFKB1 TLE1 RELA RING1 FBXW7 SAP30 CUL1 NCOR2 NCOR1 MFNG NUMB MAML3 NOTCH2 NOTCH3 HDAC2 NOTCH1 NOTCH4 PSEN2 SMAD2;SMAD3 DTX1 FURIN JAK2 PSEN1 DLL1 DLL3 APH1A DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 STAT3 NCSTN APH1B SMAD4 HES1 HIVEP3 SPEN JAG2 JAG1 ITCH SNW1 M-CSF%IOB%M-CSF M-CSF STAT5A PIK3R1 STAT3 PTPN11 AKT1 GRB2 STAT5B CSF1R CSF1 INPPL1 ETS2 RIPK1 PSTPIP2 FADD GRAP2 MYO18A VIM TFE3 PTK2 GAB3 DNM1 PRKCD MITF CASP8 PTK2B SHC1-1 CBL INPP5D EGFR1%IOB%EGFR1 EGFR1 EPN3 ACTA2 ELF3 PEAK1 MYH9 DOCK1 GRB14-1 RALB MVP RGS16 ASAP1 ATP1A1 PDLIM1 MARVELD2 REPS2 MTA2 PDLIM4 SNCA EGF SPRY4 PPP2R3A HSPE1 TNIP1 SPRY3 SPRY2 SPRY1 ZPR1 STK11 MYC AKT1 TGIF1-1 PRKCG MAP2K3 PRKCB PRKCD ZFYVE16 HGS TP53 PXN PIK3R2 PIK3R1 SMAD2;SMAD3 JUN JUND CAV1 PTK2 DAB2 SP1 CDK2 CDK1 FOXO1-1 FOS RHOA CRK HDAC1 MAPK8 MAPK1 MAPK3 AP2B1 MAPK14 BCAR1 GSK3B IRS2 ELK1 MAPK9 MAPK7 PTK2B PLCG1 RAF1 SHC1-1 STAT1 SRC NFKB1 RELA KHDRBS1 EGFR JAK2 STAT3 PTPN11 RPS6KB1 GRB2 STAT5B MAP2K2;MAP2K1 GAB1 SH3KBP1 CLTC CBLB CRKL RPS6KA1 HRAS PRKCA DOK1 PIK3CA RASA1 KIT SOS1 GRB7 CBL SOCS1 EIF4EBP1 ABL1 FYN STAT5A LYN MTOR CFL1 GSK3A YWHAB CDH1 RAC1 ARHGEF4 CTBP1 JUP RIPK1 BCL2 CASP9 ANXA4 LCK MET PLEC CDC42 CD59 NEDD4 PTPN6 PKN2 VIM ITGB4 PIK3CD PIK3CB PIK3CG EPHB2 DSP YWHAZ COL17A1 PIK3R3 PAK1 ERBB2 BAD ERBIN PRKCI CREB1 FRS2 GRK2 DYRK1A RPS6KA2 VAV1 PFN1 STAM2 STAM NOS3 DOK2 NCK1 RPS6KA5 ERBB3 JAK1 STAT2 TYK2 PRKAA1 APP ITCH INPPL1 DNM1 USP6NL ATF1 ITSN2 RPL30 TFRC ARAF HNRNPR ENO1 ELK4 EPS8 GJA1 UBASH3B TFG MPRIP ANKS1A SCRIB KIAA1217 PRKAR1A PARD3 PRKD1 RBCK1 KRT6B;KRT6C;KRT6A SERPINB3;SERPINB4-1 IQGAP1 PRKCZ SLC5A5 LDHA ANTXR1-1 MYO6 PLCG2 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 SHB ENSA PLEKHN1 APPL2 APPL1 ANXA1 ANXA2 PGAM1 EPS15L1 PLSCR1 GPRC5A HNRNPA1-1 TKT PHLPP1 AHNAK HTT RPS27L SNX33 AP2S1 FLNB STX4 RPS2 LDLR DDX3X-1 GSN MCF2 HIPK3 DCBLD2 HIPK2 ABI1 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CDH3 CYSRT1 CDH2 TOM1 GRB10 MAP3K4 MAGI1 PIAS3 DYRK4-1 DYRK1B PRPF4B TOM1L1 TOM1L2 HAT1 PKP2 ADAM9 PKP4 PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG SOCS3 STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 MAP2K5 TNK2 PTPRE CDK5 PTPRA ACTB-1 ALB MAP3K14 RAB5A EIF4G1 BCAR3 ITGB1 CALCOCO2 PTEN PTPN23 PIK3C2B NCK2 SFPQ-1 ACP1 CCDC50 ACTR2 PDCD6IP ITGA3 PKM DSG2 SOS2 SLC25A6 CEBPA CEBPB PRKAA2 WBP2 SRI SLITRK6 CSK RBBP7 CTNNAL1 SH2B1 PTPN18 PTPN1 PPP1R14B PTPN12 BAIAP2 NECTIN1 ERRFI1 AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 SLC12A7 EPHB1 RPS10 TNS3 EPHB4 TNS2 EPHB3 TNS1 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 RIN1 EPHA1 TLN1 EPHA2 SDC4 ASAP3-1 SDC3 PTTG1IP MYL12B RACGAP1 RALGDS SNX5 VASP INSR PTK6 SPART SMU1 SDC1 CALM1 CALM2 CC2D1A PTPRR HIP1 AP2A1 WASL PTPRK LIMD1 PTPRF OTUD6B GIT1 VAV3 RALBP1-1 MINK1 IL17RD VAV2 CTTN ARHGEF7 ALDOA ARHGEF5 CSTB NEDD9 PRKX SH3BGRL PDZD11 CDV3-1 MAP4K5 EPS15 MPZL1 UBB;UBC MAP3K2 GIT2 MAP3K3 MAP3K1 CAVIN1 CAVIN2 HUWE1 PLEKHA5 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL EPPK1 ESYT1 TJP2 SH3GL3 PRAG1 PEBP1 ARHGAP35 SH3GL2 PDGFRB KIRREL1 APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 SDCBP CALD1 CASKIN2 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 FLOT2 KLF11 PDPK1 LSR ARAP1 EPN1 EPN2 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor NCOA1 TOP1 KAT2B HDAC1 APPL1 FOXA1 CALR-1 CCNH BUB1B-PAK6;PAK6 AHR UXT CCND3 KAT5 ZMIZ1 ZMIZ2 PIAS4 DAPK3 PNRC1-1 GTF2F1 GTF2F2 CTNNB1 TLE5 PIAS1 GSN CDC25B CDC37 IL6ST SF1 GSK3B MDM2-2 HSP90B1 BRINP1 PRDX1 BAG1 LPXN PATZ1 XRCC6 POU2F1 UBE2I HSPA5 XRCC5 NONO SRC PIAS3 PA2G4 NR0B2 RELA CDK9 CDK7 RBAK RNF14 TGFB1I1 FHL2 EFCAB6 TRIM68 RAC3 NELFCD PELP1 NCOA2 HSP90AA1 NCOA6 EGFR PRMT1 NCOA4 ARNT ETV5 SENP1 SLC25A4 NCOA3 DDC TMF1 STAT3 COX5B RCHY1 RNF4 NR2C2 NR2C1 PSMC3IP NSD1 NSD2 NRIP1 FLNA SRY PTEN SPDEF SVIL RANBP9 GTF2H1 STUB1 VIP PARK7 RAN RACK1 CEBPA RB1 CCND1 AKT1 EP300 TGIF1-1 DAXX RUNX2 CDC25A AR CCNE1 SIN3A PXN NCOR2 PIK3R1 PPP1CA SMAD2;SMAD3 TCF4 CDK11A;CDK11B HSPA8 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 JUN SMAD4 CAV1 ESR1 SP1 HSPB1 CASP7 CASP8 CASP3 CASP1 BRCA1 PRKD1 PARP1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 STAT5A LYN CBLB FLT3 ATF1 GAB2 CREB1 ATF2 CEBPA STAT3 JUN AKT1 CBL MAPK1 GAB1 MAPK3 CD40%IOB%CD40 CD40 LCK LYN PIK3R1 MAPK14 PLCG2 IKBKB CHUK SYK FGR JAK3 MAPK9 STAT3 JUN MYC MAPK8 AKT1 NFKBIA MAP2K2;MAP2K1 MAPK1 FYN MAPK3 TNFSF3%IOB%TNFSF3 TNFSF3 TRAF3 TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA LTBR LTB JUN NFKBIA NFKB1 RELA TRAF2 ID%IOB%ID ID RB1 RBL2 SMAD2;SMAD3 CDK2 ELK4 RBL1 PAX5 ELK1 ELK3 PSMD4 MYOD1 ID1 ID4 ID3 HES1 ID2-1 MYF5 ATF3 TCF7L2 G-CSF%IOB%G-CSF G-CSF SYP SOD1 STAT5A LCK IL3RA LYN POM121;POM121C REL PRKCI SOCS3 JAK2 STAT3 JAK1 PTPN11 AKT1 TYK2 GRB2 STAT5B MAPK1 MAPK3 MAPK14 GAB2 TPTEP2-CSNK1E;CSNK1E RPS6KA1 CDK2 SYK HCK SHC1-1 CBL CSF3 CDKN1B INPP5D STAT1 CSF3R PLA2G1B FTH1 CISH EPO%IOB%EPO EPO STAT5A FOXO1-1 FOXO4 BAD FOXO3 SGK1-1 NOS3 MTOR H2BC21 EPOR HCLS1 BRAF JAK2 RPS6KA5 GSK3A STAT3 JUN PTPN11 AKT1 STAT5B MAP2K2;MAP2K1 MAPK1 MAPK3 GAB1 CRKL SYK VAV1 IRS2 RAF1 SH2B2 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma STAT5A PLCG2 SPI1 HOXA10 IFNGR1 MAPK11 EGFR IRF1 IRF2 IRF8 JAK2 CRK STAT6 STAT3 JAK1 MAPK8 AKT1 PLA2G4A PRKCQ MAPK1 MAPK3 MAPK14 CRKL CEBPB RAF1 CBL STAT1 TNFSF1%IOB%TNFSF1 TNFSF1 TRAF3 IKBKG TNFRSF1B TNFRSF1A RELB NFKB2 TRAF5 LTA TNFRSF14 LTBR JUN AKT1 NFKBIA NFKB1 RELA TNFALPHA%IOB%TNFALPHA TNFalpha TRAF1 TRAF3 CSNK2A1;CSNK2A3 BID CFLAR PKN1 YWHAE CDC37 YWHAQ YWHAH BRINP1 YWHAZ UBE2I CDK9 CREB1 HSP90AA1 NR2C2 FLNA IKBKB TNFRSF1B RACK1 TNFRSF1A RELB NFKB2 CHUK TRAF5 SYK NFKBIA BCL3 REL RB1 RPL4 SMARCB1 RPS6KA5 RPL8 RPL6 DCAF7 PSMD6 PSMD7 TBK1 PSMD2 AKT1 AKT2 PSMD3 DPF2 BTRC PSMD1 MAP3K7 RPS11 RPS13 SMARCC1 SKP1 SMARCC2 TRADD PSMC2-1 CDC34 KCNQ1 TRIB3 IQGAP2 GLG1 IKBKG CRADD SMARCA4 NKIRAS1 NKIRAS2 PRKCD IKBKE RIPK3 ACTL6A COMMD1 AKAP8 TANK PSMB5 ELP1 LRPPRC KTN1 PSMC3 PSMC1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 MAP3K8 KPNA2 AZI2 FBXW7 KPNA3 CUL1 GTF2I UNC5CL FBXW11 USP2 TRPC4AP TXLNA FANCD2 MAPKAPK2 HDAC2 NUPR1 NSMAF FKBP5 COPB2 PSMD12 PSMD13 TNFRSF11A MAP2K6 RASAL2 BAG4 NLRP4 G3BP2 JUN MCC COPS3 CREBBP ALPL TAB3 TAB2 NFKBIE MAP3K11 NFKBIB HSP90AB1 MCM7 CAV1 TNFAIP3 PPP6C BCL7A PPP1R13L NFKBIZ YWHAG PEG3 TRAF7 TRAF4 RASA3 COPS5 POLR1A RPL30 TRAF6 POLR1B POLR1C POLR1D POLR1E MCM5 PFDN2 BIRC2 TAB1 USP11 MTIF2 HDAC6 TIFA POLR2H POLR2L SMARCE1 SPAG9 UBE2D3-1 RNF25 TNIP2 PRC1 GLB1 SUMO1 PDCD2 PRKCZ TBKBP1 HDAC1 MAPK8 MAPK1 MAPK3 UBE2D3;UBE2D2 MAPK14 PML DDX3X-1 MAPK9 STAT1 SRC NFKB1 RELA EGFR MAP2K5 PTPN11 RPS6KB1 MAP3K14 GAB1 DOK1 STAT5A YWHAB MARK2 MAP3K2 MAP3K3 MAP3K1 RIPK1 FADD FAF1 HSPB1 CASP7 CASP8 CASP10 CASP3 CASP2 TRAF2 GDNF%IOB%GDNF GDNF RET PXN CDC25C TH RPS6KA3 PTK2 MET BCAR1 CDK1 DOK1 CRK JUN PTK2B RPS6KB1 RAF1 NFKBIA MAP2K2;MAP2K1 FYN GAB1 TNFSF8%IOB%TNFSF8 TNFSF8 TRAF1 TRAF3 REL AKT1 RELB BCL3 NFKB2 MAPK1 TNFRSF8 NFKB1 RELA CXCR4%IOB%CXCR4 CXCR4 LCK ITK LYN ITGB2 RHOA PLCG2 ICAM1 LCP2 USP14 CXCR4 NCK1 GNAI1 GNA13 GRK6 VCAM1 FYB1 CCR5 LIMK1 CFL1 ESR2 CXCL12 ACKR3-2 CRK YWHAB STAT4 STAT2 RAC1 SDC4 MAPK1 MAPK3 PTPN6 MAP2K3 PRKCD BCAR1 GSK3B ELK1 PTK2B PLCG1 VAV2 STAT1 SRC NFKB1 RELA ZAP70 PXN PIK3R2 PIK3R1 BAD FOXO3 CREB1 EGFR JAK2 JAK3 HSPA8 STAT3 RPS6 PTPN11 RPS6KB1 STAT5B MAP2K2;MAP2K1 CBLB PTK2 CRKL IKBKB ATF1 RPS6KA2 CHUK VAV1 DOK1 RASA1 ARRB2 WAS CBL NFKBIA INPP5D PTPRC FYN CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 CABIN1 PRKACA-1 CHP1 JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS CALM3;CALM1 IL2 IL4 FOSL1 FKBP1A RCAN1 IL3 CD40LG IFNG IL2RA RCAN2 PTGS2-2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling IL5 COL1A2 CDK4 SP1 SP3 CDK2 DCP1A JUN FOS ATF2 CDKN1A ITGB5 CITED1 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A EP300 AKT1 SNIP1 TGIF1-1 NCOA1 PIAS4 IL10 NCOA2 PIAS3 MEF2C TGIF2 FOXH1 TFE3 FOXO1-1 RUNX3 RUNX2 SAP30 RUNX1 KAT2B AR KAT2A CREB1 RBL1 TFDP1 NCOR1 MYOD1 IRF7 ATF3 E2F4-1 DLX1 HDAC2 CEBPB CBFB HDAC1 MAX CTBP1 FOXG1 GATA3 FOXO4 FOXO3 RBBP4 GSC SMAD2;SMAD3 SAP18 RBBP7 NKX2-5 E2F5 SKIL HSPA8 ZBTB17 CDKN2B CREBBP SMAD4 IFNB1-4 VDR ESR1 SMAD7 SKI IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events CCL13;CCL2 CXCL9 IL23R IL24 ALOX12B PIK3R1 CD3E TNF MPO RELA SOCS3 IL18RAP STAT4 IL12B IL12RB1 JAK2 STAT5A NOS2 STAT1 ITGA3 STAT3 IL18 CXCL2;CXCL3;CXCL1-1 IL19 TYK2 NFKB1 NFKBIA IL6 CD4 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression RANGAP1 RAN PIAS2 PIAS1 HDAC1 RANBP2 HDAC4 UBE2I XPO1 SUMO1 MDM2-2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events MAPK3 VAV3 MAP3K1 GSN SYK CHUK MMP2 MMP9 RHOA MAP3K14 BCAR1 CD44 PIK3R1 RELA NFKB1 NFKBIA PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 PIP5K1A MAPK1 PTK2B ITGAV RAC1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events MAPK3 ACVRL1 BMPR2 TGFBR1-1 ARRB2 ACVR1 SMAD1 TGFB1 TGFB3 CAV1 GDF2 SMAD9 INHBA SMAD5 ACVR2B ACVR2A TGFBR2 PPP1CA TLX2 CSNK2B ID1 ENG FKBP1A SMAD4 MAPK1 SMAD7 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase MAPK3 RHOA BCAR1 PIK3R1 CREB1 RET GRB7 IRS1 SRC PRKACA-1 PIK3CA PXN IRS2 RAP1A JUN GRB10 HRAS PDLIM7 NCK1 GAB1 FRS2 GFRA1 PTPN11 PRKCA PTK2 DOK1 DOK4 GDNF DOK5 RASA1 DOK6 MAPK8 GRB2 SOS1 CRK SHANK3 MAPK1 SHC1-1 RAC1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events SDCBP MAPK3 CCL5 COL1A2 BSG FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 FGF19 COL4A4 COL7A1 COL6A2 COL6A1 TGFB1 COL5A2 COL4A3 COL4A6 SDC1 COL4A5 COL6A3 HPSE PPIB FGFR4 MET FGFR3 PRKACA-1 MAPK1 LAMA5 COL11A1 COL11A2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS RASA4;RASA4B HRAS SYNGAP1 LGALS1 RRAS PLCE1 PRKCB CALM3;CALM1 PRKCE DAB2IP PRKCA RASA2 NF1 KRAS RIN1 SOS2 RASA1 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events IL5 COL1A2 SP1 COL1A1 PIK3R1 SOCS3 JAK2 STAT5A PIK3CA IL4 ITGB3 CD40LG PIGR SPI1 ETS1 MYB IL13RA2 JAK3 MYBL1 JAK1 IL13RA1 IL4R ARG1 GTF3A OPRM1 FCER2 AKT1 DOK2 IRF4 LTA RETNLB CCL11 IL10 ALOX15 THY1 IL2RG CBL TFF3-1 SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 MAPK14 PARP14 MTOR AICDA SELP RPS6KB1 BCL6 FES PTPN6 BCL2L1 CCL26 IRS1 CEBPB IRS2 GRB2 SHC1-1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K JAK1 MYC AKT1 PIK3R1 IL2RG RELA MTOR RPS6KB1 NFKB1 BCL2L1 PRKCZ SGMS1 UGCG PIK3CA TERT SMPD1 E2F1 HSP90AA1 RPS6 GAB2 LCK IL2RB FOXO3 BCL2 CALM3;CALM1 EIF3A PTPN11 IL2 IL2RA GRB2 SOS1 MYB SHC1-1 JAK3 RAC1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling MAP2K2;MAP2K1 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 NOS3 EGF BDNF NTRK3 IGF1 VEGFA PIK3R1 AFDN TEK JAK2 STAT1 IL6 PRKACA-1 PIK3CA NRAS IL2 KRAS IFNG IL2RA JAK3 JAK1 RHOA IL2RG IRS1 HRAS GAB2 LCK GAB1 IL2RB FRS2 ARHGAP35 PTPN11 IGF1R KDR IL6R PDGFRB LMO4 IFNGR1 NGF FRS3 IL6ST GRB2 SOS1 RAF1 SDC2 PDGFB GNAI3 SHC1-1 GNAI1 EGFR NTF4 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network EP300 NCOA1 RB1 CAMK2D CDKN1B NOTCH1 KDM1A MAML2 MAML1 GATA6 RUNX2 GATA4 JAK2 RBPJ ASCL1 GATA1 AR HIF1A GHR STAT3 YY1 HEY1 HEY2 NCOR1 RBBP8 MYOD1 HES1 SPEN HES6 TLE1 CD4 PARP1 GAA ARNT HDAC1 E2F1 NCOR2 PTF1A CTBP1 NEUROG3 KDR RCAN1 CREBBP MYB INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGA3 ITGB1 ITGAM ITGB4 ITGB2 ITGA2B ITGAE ITGAL ITGAX ITGB8 ITGB7 ITGB6 ITGB3 ITGA4 ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGB5 ITGA7 ITGA6 ITGAV ITGA5 ITGA9 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events RAB1A ERCC6L PPP2CB;PPP2CA BUB1B AURKA CDC14B PPP1CB GOLGA2 CDC20 RHOA PAK1 CCNB1 FZR1 PPP2R1A CLSPN FBXO5 ECT2 BTRC BUB1 CENPU NUDC BORA PPP1R12A FBXW11 ODF2 PLK1 TUBG1 CDC25C NDC80 CDC25B SGO1 CENPE TPX2 WEE1 STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ TPT1 SPC24 ROCK2 INCENP BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events TP53 ATR CDK2 RBBP8 MRE11 PCNA PRKDC BRCA1 UBE2D3-1 NBN TOPBP1 BARD1 XRCC6 XRCC5 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 RAD51 CCNE1 FANCD2 EWSR1 ATM S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA GNAI3 GNAI1 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma NTRK1 YWHAE AKT1 GSK3B YWHAB CAMK2A AGAP2 PIK3R1 CCND1 YWHAQ EPB41L1 SFN PLCG1 YWHAG YWHAH EGR1 TRPC3 BAD PDPK1 STAT5A PRKCD TRPV1 YWHAZ CAMK4 CREB1 SRC PIK3CA NRAS HRAS GAB1 FOXO3 KRAS NGF GRB2 SOS1 SHC1-1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 CD3E IL18RAP TGFB1 STAT4 CD86 STAT3 CD80 IL18 PRF1 CD3G CD3D MAPK9 TBX21 IL13 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 ETV5 IRF1 CD28 JUN HLA-DRA CD247 IL18R1 FOS IL2 PIAS2 IFNG IL2RA MAPK8 CREBBP AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling DES BIRC5 TACC1 NCAPD2 AURKA KIF2C VIM RHOA BUB1 NDC80 SGO1 KIF20A CUL3 NCAPG PEBP1 CDCA8 KLHL13 CENPA SMC4 NPM1-2 NCAPH MYLK SMC2 PPP1CC RACGAP1 STMN1 INCENP RASA1 AURKC EVI5 AURKB CBX5 SEPTIN1 NSUN2 KIF23 PPP2R5D KLHL9 NCL-1 PSMA3 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events MAP2K2;MAP2K1 MAPK3 DAPK1-1 TRIO PITPNA RHOA WASL PAK1 CAMK2A NTN1 BCAR1 AGAP2 FYN PIK3R1 YES1 MYO10 UNC5A DCC PLCG1 UNC5B UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 PTK2 CDC42 MAPK1 RAC1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway MAPK3 GNAO1 GNAZ GNA12 S1PR5 GNAI2 RHOA PLCG1 GNA13 S1PR4 CDC42 GNAI3 MAPK1 GNAI1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events MAP2K2;MAP2K1 PDE3B PIK3CG PIK3R6 MAPK1 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network WNT1 ELANE COL1A2 ZFHX3 CBX4 SP1 CDKN2A ATP2B1 SMARCA2 GSTM1;GSTM2-1 HIPK2 KITLG CDK6 MYF6 CCND1 TAB2 TAB1 ADA MPO CDKN1B GATA1 HES1 CD4 NRAS UBE2I KRAS PTGS2-2 SPI1 CDKN1A ETS1 MYB SIN3A MYC EP300 CCNB1 PIAS3 SLC25A3 LECT2 CLTA LYZ-1 YEATS4 NCOR1 ETS2 MYOD1 PPP3CA CA1 TRIM28 CASP6 ANPEP PIM1 CEBPB TOM1 RAG2 CD34 HRAS MAP3K7 PTCRA H2AZ2;H2AZ1 GATA3 PAX5 SND1 BCL2 CCNA1 MAF ADORA2B TFEC KIT MCM4 ZFPM1 MAD1L1 PPID HSPA8 BIRC3 CSF1R CEBPA CREBBP COPA CEBPD LEF1 IQGAP1 NLK MAT2A SKI EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling MAP2K2;MAP2K1 MAPK3 WASL PAK1 PIK3R1 ROCK1 ITSN1 EFNA5 KALRN RAP1B EFNB2 EFNB1 EFNB3 EPHB2 EPHB1 EPHB4 EPHB3 MAP4K4 DNM1 TF SYNJ1 GRB7 SRC PIK3CA PXN RAP1A NRAS HRAS NCK1 RRAS PTK2 KRAS RASA1 CDC42 GRB2 CRK MAPK1 SHC1-1 RAC1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAP3K1 SYK CHUK AKT1 PIK3R1 PDPK1 MAPK14 CLTC FAIM2 MAPK9 FASLG PIK3CB IKBKB CASP8 SRC CASP10 PIK3CA CASP3 SMPD1 RIPK1 FADD IKBKG BID MAP2K7 MAP2K6 RFC1 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAPK8 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK4 PLK2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway MAP2K2;MAP2K1 MAPK3 KSR1 CRADD MAP3K1 SPHK2 EIF2AK2 MYC PAWR TRAF2 TNFRSF1A AKT1 EGF PRKRA MADD BAX IGF1 NSMAF RB1 TNF RELA BAD PRKCD MAP4K4 NFKB1 NFKBIA PRKCZ CASP8 SMPD1 RIPK1 FADD BID BCL2 ASAH1 TRADD BIRC3 PDGFA MAPK8 SMPD3 RAF1 CYCS-1 BAG4 AIFM1 MAPK1 CTSD EIF2A MAP2K4 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling SYK PRKN FYN BLK YES1 MAOB PARK7 PLD1 SLC6A3 KLK6 PLD2 UCHL1 GRK5 SNCA BAD LYN TOR1A PRKCD SNCAIP FGR HCK TH STUB1 CSNK2A1;CSNK2A3 PLCB2 SRC LCK FKBP1A PPP2R5D PTK2B ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway NFKB1 REL NFKBIA IKBKB SYK SRC PIK3CA LCK PIK3R1 ARRB2 RELA BTRC MAPK14 BCL3 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway RHOA ROCK1 PLD1 CDKN1B PLD2 PPP1R12A SRF PTEN PRKCZ SLC9A1 PARD6A CFL1 PIP5K1B PIP5K1C JUN CCN1 SH3GL2 ITGB1 SCAI MAP2K6 MAP2K3 LIMK2 RDX FOS LIMK1 MSN MRTFA MAPK12 CIT EZR DIAPH1 ROCK2 SLC9A3 ACTA1 MYL2 CDC42 PKN2 MAPK8 PKN1 TLN1 ATF2 F2RL2 PIP5K1A VCL MAP2K4 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B CDH2 LEPR CAPN1 PRLR CSN2-1 TXN CSK PTPN1 EGF INSR FER TRPV6 LEP PIK3R1 NOX4 SPRY2 LAT SOCS3 JAK2 STAT5A STAT3 TYK2 PIK3CA ITGA2B ITGB3 AKT1 RHOA BCAR1 FYN BLK YES1 CAV1 LYN STAT5B FGR HCK IRS1 SRC LCK DOK1 PDGFRB CSF1R GRB2 CRK PDGFB CSF1 SHC1-1 PRL YBX1 EGFR INS;INS-IGF2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events SDCBP MAPK3 FGF23 MMP2 CASK RHOA BAX FGF19 CXCL8 TNFRSF13B EPB41 LAMA1 TGFB1 LAMA3 KNG1 RACK1 CAV2 EPHB2 TRAPPC4 PRKCD FN1 FGFR4 FGFR3 CSF2 SRC PRKACA-1 CASP3 HRAS ITGB1 NF1 EZR ITGA2 RASA1 MAPK8 SDC2 MAPK1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway MAP2K2;MAP2K1 MAPK3 NRAS HRAS FOS PRKCB PRKCA KRAS BRAF RAF1 ELK1 MAP3K8 MAPK1 PTPN7 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network CDK4 CCND1 RB1 CXCL8 SOCS3 NOS2 HBG2;HBG1 HRK ACHE DUSP10 MAPK9 HES1 CSRP2 KAT5 IL6 RUVBL2 CCNA2-1 PDGFRA IL23A JUNB DUSP5 DUSP1 JUN DUSP8 SERPINB5 CUL3 POU2F1 DDIT3 JDP2 MACROH2A1 FOS PPARGC1A TGFB2 JUND MAPK11 COL24A1 GADD45A SELE NF1 IFNG MAPK8 PLAU ATF2 MAPK1 MAPK3 ARG1 EP300 MMP2 MAPK14 CREB1 TH ATF3 BCL2L1 CBFB BRCA1 BCL2 PRKCA ESR1 INS;INS-IGF2 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling EPHA3 VAV3 NGEF EPHA2 RHOA FYN BLK YES1 ROCK1 CBL PLCG1 EFNA5 LYN PIK3CG PIK3R6 FGR HCK SRC LCK CRKL EPHA5 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 CRK EFNA1 EFNA3 EFNA2 CDK5 EPHA1 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I TNF RELA GATA1 STAT3 YY1 NFKB1 NFKBIA PRKACA-1 NCOR2 RANBP2 HDAC4 UBE2I XPO1 SUMO1 RANGAP1 RAN SIN3B HDAC10 SIN3A HDAC11 CHD4 CHD3 EP300 TNFRSF1A SMG5 PRMT5 SIRT4 SIRT5 SIRT6 SIRT1 SIRT2 SIRT3 WDR77 BTRC PPARG FKBP3 HDAC5 HDAC3 GATA2 HDAC8 SAP30 NR2C1 HDAC9 KAT2B HDAC6 HDAC7 MTA2 MBD3 SMURF1 MBD2 NCOR1 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 GATAD2B GATAD2A TFCP2 MXD1 HDAC2 HDAC1 MAX RBBP4 SAP18 RBBP7 ZFPM1 CREBBP SMAD7 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events PLD1 PLD2 ITGA3 CLTC CTNND1 SLC2A4 ASAP2 ADRB2 KLC1 PIP5K1C CDH1 CTNNA1 ITGB1 SPAG9 EXOC7 AVPR2 RALA-1 MAPK8IP3 TSHR DNM2 SCAMP2 NME1 ACAP1 BIN1 ITGA4 AGTR1 ITGA2 EXOC4 ITGA1 EXOC3 CPE ITGA10 CTNNB1 ITGA11 EXOC6 ITGA8 EXOC5 ITGA7 EXOC2 ITGA6 ARF6 ITGAV ITGA5 VAMP3 INS;INS-IGF2 ITGA9 EXOC1 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling ZFAND5 SGK1-1 SKP2 CSNK1G3 USP7 MST1 CDK2 CSNK1D YWHAE RBL2 CAT YWHAB CSNK1G2 CSNK1G1 RALB BCL2L11 YWHAQ CSNK1A1 SOD2 SFN FBXO32 CDKN1B G6PC1 YWHAG TPTEP2-CSNK1E;CSNK1E YWHAH YWHAZ MAPK9 FASLG IKBKB XPO1 MAPK10 GADD45A RAN MAPK8 CHUK EP300 AKT1 CCNB1 SIRT1 FOXO1-1 KAT2B PLK1 BCL6 FOXO4 RALA-1 FOXO3 CREBBP CTNNB1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway SPHK2 GNAO1 GNAZ GNA12 S1PR5 GNAI2 ABCC1 SPHK1 SGPP1 GNA13 GNA14 SGPL1 S1PR4 GNA15 GNA11 GNAQ S1PR1 S1PR3 GNAI3 S1PR2 GNAI1 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt CHUK YWHAE AKT1 GSK3B YWHAB YWHAQ SFN CDKN1B YWHAG YWHAH FOXO1-1 BAD PDPK1 YWHAZ MTOR GSK3A MAPKAP1 CASP9 AKT2 AKT3 BCL2L1 MLST8 RICTOR SRC SLC2A4 PRKACA-1 KPNA1 MAP3K5 TBC1D4 HSP90AA1 PRKDC FOXO4 FOXO3 RAF1 CDKN1A E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction AKT1 RHOA PIK3R1 CCND1 AFDN RAP1B CTNND1 SRC PIK3CA CYFIP2 RAP1A PIP5K1C NCKAP1 CDH1 CTNNA1 WASF2 AP1M1 JUP KLHL20 TJP1 ENAH ITGAE TIAM1 DLG1 CTTN NME1 ABI1 ITGB7 RAPGEF1 CDC42 CTNNB1 VAV2 CRK IQGAP1 ARF6 RAC1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family GRK2 SMO BOC GAS1 PIK3CA CDON AKT1 PIK3R1 TGFB2 ARRB2 LRPAP1 STIL DHH PTCH1 HHIP PTCH2 IHH LRP2 PTHLH GLI2 SHH HHAT POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK4 PLK3 PLK2 PLK1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 MAPK9 CYFIP2 JUN NCKAP1 WASF2 MAP2K7 MAP2K6 ABI1 RACGAP1 MAPK8 ATF2 PIP5K1A RAC1 MAP2K4 MAP3K1 WASF1-1 NCF1 NCF2 ARPC1B PAK1 ARHGAP5 BCAR1 ARHGDIA ACTR2 CYBB CYBA NOXO1 IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 ABI2 ARPC3 MAPK14 NOXA1 ACTR3-1 MAP3K11 NOX1 PLCB2 CFL1 PIP5K1B PIP5K1C CDH1 CTNNA1 MAP2K3 LIMK1 CTNNB1 CRK IQGAP1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones ARR3 RPE65 GRK1 RDH12 GNAT2 RGS9BP GRK7 RDH5 GNB3 CNGB3 PDE6C LRAT CNGA3 GNB5 RGS9 LOC118142757;GUCA1A SLC24A2 GUCY2D PDE6H GUCA1C REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity APC VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 ARHGDIA ITSN1 PLCG1 ITSN2 DOCK6 BCAR3 NME1 ARHGEF25 DOCK9 ARHGAP1 RACGAP1 ARHGAP17 FGD1 CDC42 DOCK10 DOCK11 MCF2L VAV2 GIT1 FARP2 RALBP1-1 MCF2 DNMBP HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network SP1 FLT1 CITED2 EPO EP300 EPAS1 SLC2A1 POU5F1;POU5F1B ELOC-1 PGK1 VEGFA ELOB SIRT1 VHL HIF1AN EGLN1 EGLN3 EGLN2 SLC11A2 MMP14 ADORA2A APEX1 BHLHE40 EIF3E FXN ABCG2 ELK1 ARNT KDR CREBBP ETS1 EFNA1 SERPINE1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity SMARCA2 GSK3B EGR1 RACK1 EHMT2 ZMIZ2 TRIM24 KLK3;KLK2 SMARCC1 SENP1 PDE9A TMPRSS2 KAT5 NR2C2 HOXB13 RCHY1 RXRB RXRA SRY JUN RXRG SPDEF POU2F1 SMARCE1 MAP2K6 NR0B1 APPBP2 DNAJA1-1 CARM1 MDM2-2 MAPK8 MAP2K4 NR3C1 EP300 NCOA1 SIRT1 NCOA2 FOXO1-1 GATA2 NR2C1 KAT2B MAPK14 AR HDAC7 REL SRC HDAC1 HSP90AA1 PKN1 CEBPA CREBBP PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway JAK1 SRF PIK3CA PDGFRA JUN PIK3R1 FOS CAV3 SHB PLCG1 SHF CRKL RAPGEF1 CAV1 GRB2 SOS1 ELK1 CRK SHC1-1 CSNK2A1;CSNK2A3 ITGAV SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events FGF23 SRC CASK FYN FGF19 CXCL8 CTTN PSENEN NCAN SDC3 PSEN1 PTN POMC MC4R APH1A NCSTN FGFR4 APH1B AGRP FGFR3 EGFR SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta ELK4 TP53 RPS6KA4 RPS6KA5 MKNK1 EIF4EBP1 EIF4E MEF2A KRT8 PLA2G4A MITF USF1 KRT19 MAPKAPK3 MAPKAPK2 HBP1 MEF2C MAPKAPK5 RAB5A ATF6 NOS2 MAPK14 CREB1 SLC9A1 CEBPB JUN DDIT3 PPARGC1A MAPK11 PTGS2-2 ATF2 ATF1 ESR1 GDI1 HSPB1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events BCAR1 IGSF8 CD81 THBS2 DOCK1 THBS1 PRKACB-1 ADAM28 MDK FN1 CD14 YWHAZ JAM2 VCAM1 JAML PRKAR1B PRKAR1A PTPRA SRC PRKACA-1 PXN ITGB1 PTK2 ABI1 ITGA4 TLN1 SPP1 CRK GIT1 PTK2B ARF6 RAC1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network WNT1 LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 IGFBP4 RYK-1 FZD4 WNT3A FZD7 WNT7B FZD6 ATP6AP2 WNT5A KREMEN1 FZD9 WNT7A FZD8 KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network TIMP1 TP53 IL5 EDN1 COL1A2 ELF1 DMTF1 SP1 NTS CDKN2A MMP1 BAG1 PENK CCL13;CCL2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TCF7L2 AGT FOSL2 COPS5 CCND1 BCL2L11 FABP4 MAFG TRIP6 CXCL8 FOSB CDKN1B EGR1 HIF1A CSF2 IL6 JUNB DUSP1 JUN NFATC3 NFATC2 NFATC1 FOS JUND IL2 IL4 FOSL1 IFNG PLAU ATF2 ETS1 MYB NR3C1 MYC EP300 MMP9 IL10 TGFB1 GATA2 CREB1 TH ATF3 PTEN CDK1 CBFB CCN1 MAF ACTA1 CTNNB1 CRTC1 DMP1 MT2A ESR1 GJA1 NPPA IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events SDCBP IL5 PIK3CA PIM1 PIK3R1 PTPN11 CISH IL5RA CSF2RB LYN STAT5B JAK2 STAT5A GRB2 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling ARHGEF7 ARHGEF6 AURKA AKT1 GSK3B CCND1 RUVBL1 NCK2 ILKAP PPP1R12A TNS1 PPP1R14A GIT2 PPP1R14B PPP1R14C ACTN1 CREB1 RHOG PARVA PARVB CKAP5 ZEB1 LIMS4;LIMS1 PARVG RUVBL2 RICTOR NACA PARP1 CDC37 PXN ZYX TACC3 JUN SNAI1 HSP90AA1 ELMO2 LIMS2 XPO1 DIAPH1 ILK CDC42 CTNNB1 IQGAP1 RAC1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events CDH2 GSN PTPN1 RHOA FER PIK3R1 ROCK1 PLCG1 LRP5 CTNND1 PIK3CA PIP5K1C CTNNA1 GRIA2 DAGLA JUP DCTN1 MAPRE1-1 CNR1 CALM3;CALM1 KIF5B PTPN11 CAMK2G AXIN1 CTTN GAP43 DAGLB FGFR1 MYL2 CDC42 MAPK8 CTNNB1 GJA1 RAC1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor RARA RARB PPARA PPARD NCOA1 TNF PPARG TGFB1 RPS6KB1 RXRB RXRA NCOR2 RXRG BCL2 RARG THRB THRA FAM120B ABCA1 SREBF1 MED1 VDR NR1H2 NR1H4 NR1H3 NR4A1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A NCOR2 JUN HDAC4 NR0B1 MED1 CTSD MYC COL18A1 CHUK CALCOCO1 EP300 CD82 MPG SRA1 PHB2 NCOA1 DDX17 PDIA2 NCOA2 DSCAM NCOA3 AP1B1 DDX54 AXIN2 SAFB LCOR PGR TRIM59 NCOA7 TFF1 PRDM15 MTA1 SET-1 HSF2 NRIP1 APBB1 NCOR1 NDUFV3 ATP5PF XBP1 KLRC4;KLRC3;KLRC2;KLRC1 ABCA3 GREB1 C3-1 CEBPB POU4F1 NR0B2 HDAC1 ANP32A;ANP32D POU4F2 ESR2 SOD1 PCNA UBA3 EBAG9 BRCA1 LMO4 SMAD4 PRL ESR1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling ELF1 ANGPT1 NOS3 PIK3R1 TEK TNF RELA STAT5A FN1 ELK1 NFKB1 PIK3CA ITGB1 MAPK8 CDKN1A ETS1 MAPK1 ITGA5 RAC1 MAPK3 MMP2 AKT1 DOK2 PAK1 FYN PLD2 FOXO1-1 STAT5B MAPK14 RPS6KB1 FES GRB7 PXN NCK1 FGF2 F2 ELF2 PTPN11 GRB14-1 PLG PTK2 ANGPT4 ANGPT2 BMX AGTR1 TNIP2 RASA1 GRB2 CRK SHC1-1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells MAP2K2;MAP2K1 TNFRSF9 CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD3E TNF STAT4 EGR1 BRAF ELK1 PTPN7 PRF1 CD3G CD3D MAPK9 FASLG JUNB JUN NRAS CD247 NFATC3 NFATC2 NFATC1 FOS PRKCB CALM3;CALM1 PRKCE IL2 FOSL1 KRAS IFNG IL2RA MAPK8 MAPK1 MAPK3 IL2RG HRAS IL2RB PRKCA TNFRSF4 B2M GZMH;GZMB-1 IFNAR2 RAF1 EOMES TNFRSF18 CD8A PRKCQ IFNAR1 EGR4 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase MAP2K2;MAP2K1 CAPN2 ARHGEF7 SH3GL1 ARHGEF11 ARHGEF28 ASAP1 PTPN21-1 ARHGAP26 KLF8 CCND1 PIK3R1 PLCG1 RAP1B NCK2 GIT2 BRAF ACTN1 MAPK9 PIK3CA JUN ITGB1 RRAS RAPGEF1 ROCK2 MAPK8 ETS1 ITGB5 MAPK1 ITGAV ITGA5 RAC1 MAP2K4 RHOA WASL PAK1 BCAR1 FYN YES1 ELMO1 DOCK1 GRB7 SRC PXN RAP1A NCK1 MAPK8IP3 ARHGAP35 PTK2 BMX ACTA1 RASA1 GRB2 SOS1 TLN1 RAF1 CRK VCL ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMA1 LAMA3 LAMB3 LAMA2 ITGB4 LAMB2 LAMA5 ITGA6 LAMC2 LAMB1 LAMC1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway ATR BLM WDR48 BTRC CENPS-CORT;CORT;CENPS FAAP24 BRCA2 BRIP1 LOC105377022;FANCB CHEK1 FBXW11 USP1 ATRIP FAAP100 FANCI RFC5 RFC3 RFC4 FANCM RMI1 HES1 RFC2 TOP3A XRCC3 RPA1 RPA2 HUS1 PALB2 UBE2T RAD17 RAD1 MRE11 FAN1 RAD9A BRCA1 NBN TOPBP1 FANCL FANCA FANCC FANCE FANCG FANCF RAD50 FANCD2 ATM VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms KRT5 POU2F2 IL1A ITCH TP63 CDKN2A AXL FASN RAB38 GSK3B FOSL2 COL5A1 HBP1 ADA SFN NOTCH1 BRCA2 RACK1 RUNX1 ITGA3 HES1 MRE11 TOP2A DLX5 RRAD STXBP4 MDM2-2 DLX6 TBXT SEC14L2 CCNB2 YAP1-1 PERP BDKRB2 KRT16;KRT14 HELLS TCF7L1 FBXW7 CEBPD IGFBP3 VDR ADRM1 PPP2R5A WWP1 NRG1 ATM CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis TNF PRF1 CASP9 CASP8 CASP10 PARP1 CASP3 RIPK1 BID BIRC2 TRADD SREBF1 CYCS-1 CRADD MAP3K1 GSN TRAF2 VIM TNFRSF1A APP NUMA1 MADD LMNB2 BAX LMNB1 PIDD1 CASP7 SLK CFL2 ARHGDIB CASP1 CASP2 SPTAN1 DFFB DFFA APAF1 GAS2 TOP1 SATB1 XIAP LMNA TFAP2A DIABLO-1 CASP5;CASP4 KRT18 CASP6 BCL2 LIMK1 PTK2 ACTA1 BIRC3 GZMH;GZMB-1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity VAV3 SPATA13 NGEF ARHGEF7 ARHGEF6 TRIO ARHGDIA KALRN ELMO1 DOCK1 RASGRF2 ARHGAP9 RASGRF1 RAP1GDS1 PREX2 EPS8 ABR PREX1 CHN2 CHN1 DEF6 VAV1 TIAM2 BCR ARHGEF2 DOCK2 TIAM1 DOCK6 ABI1 ARHGEF25 ARHGAP1 RACGAP1 ARHGAP17 SOS1 VAV2 RALBP1-1 MCF2 RAC1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling MST1 MMP2 MMP9 RHOA THY1 TNF ROCK1 RAP1B JAM2 HCK SELP NFKB1 IL6 RAP1A ITGAM SELPLG ITGB2 LRP1 PLAT MST1R PLG AGER ICAM1 HMGB1-1 CCN2 APOB JAM3 PLAUR PLAU TLN1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway MAPK3 RHOA PLD1 TIAM1 KALRN NME1 PLD2 PLAUR ARF1 RAB11A RAB11FIP3 PIP5K1A MAPK1 ARF6 RAC1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells LAT2 MAP2K2;MAP2K1 HCLS1 LCP2 MS4A2 PLPP1 PLA2G1B KLRG1 PTPN13 FER PIK3R1 LAT RELA PLCG1 SPHK1 S1PR1 NFKB1 IKBKB PIK3CA DUSP1 JUN IKBKG MAP2K7 NFATC2 FOS PRKCB BTK MAPK8 MAPK1 MAP2K4 MAPK3 MAP3K1 SYK CHUK AKT1 PLA2G4A FYN CBL PAK2 PLD2 INPP5D LYN PXN VAV1 HRAS GAB2 PTPN11 PTK2 DOK1 RASA1 GRB2 SOS1 RAF1 ITK WIPF1 SHC1-1 CBLB FCER1A FCER1G S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway MAPK3 GNAO1 GNAZ FLT1 GNA12 GNAI2 AKT1 CXCR4 RHOA VEGFA GNA13 GNA14 JAK2 GNA15 GNA11 GNAQ S1PR3 AKT3 SRC PDGFRB PDGFB GNAI3 MAPK1 GNAI1 RAC1 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling PTK2 ITGB7 ITGA4 PXN RHOA MADCAM1 ITGB1 VCAM1 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling MAP2K2;MAP2K1 NTF3 NTRK1 NTRK2 BDNF NTRK3 PRKCI DYNLT1 CCND1 MATK PIK3R1 SQSTM1 FAIM SHC2 SHC3 PLCG1 RGS19 MAGED1 NEDD4L RAP1B ABL1 NGFR ARHGAP32 RIT1 RIT2 EHD4 GIPC1 STAT3 DNAJA3 RHOG DNM1 RASGRF1 PRKCZ PIK3CA NRAS TIAM1 CRKL RAPGEF1 KRAS CDC42 MAPK1 RAC1 MAPK3 RHOA ELMO1 DOCK1 RAP1A HRAS GAB2 GAB1 FRS2 PTPN11 NGF RASA1 FRS3 GRB2 SOS1 MCF2L CRK SHC1-1 NTF4 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events SGK1-1 SYK RHOA FYN BLK PIK3R1 YES1 LAT PLCG1 INPP5D LYN PDPK1 PIK3CG PIK3R6 FGR HCK INPPL1 DAPP1 CYTH3 CYTH2 BLNK PIK3CB PLCG2 PTEN CYTH1 PLEKHA1 SRC PLEKHA2 PIK3CA ARAP3 ADAP1 RAP1A ZAP70 NRAS HSP90AA1 ARF5 HRAS LCK FOXO3 BTK KRAS ARF1 ITK ARF6 RAC1 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events MAPK3 PRLR ITCH FYN PIK3R1 TAB2 JAK2 STAT5B STAT5A NCOR1 PIK3CB PIK3CA ERBB4 ERBB2 LRIG1 WWOX NRG2 GRIN2B MDM2-2 EREG BTC ADAM17 NRG3 DLG4 YAP1-1 NRG4 NEDD4 HBEGF GRB2 MAPK1 SHC1-1 PRL WWP1 NRG1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events MAP2K2;MAP2K1 MAPK3 SYK CCL13;CCL2 PIK3R1 CISH CSF2RB INPP5D PRKACB-1 JAK2 LYN STAT5B STAT5A STAT1 YWHAZ STAT3 CSF2 IKBKB PRKACA-1 PIK3CA PIM1 NRAS HRAS GAB2 FOS PTPN11 KRAS CSF2RA OSM GRB2 IRF8 SOS1 RAF1 MAPK1 SHC1-1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta MAPK12 STMN1 PKN1 EEF2K MAP2K3 MAP3K20 MAP2K6 CCND1 MAPT SNTA1 MAPK13 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction LPP AQP3 LIMA1 EPHA2 MYO6 MGAT3 STX4 VASP HGF EGF PLEKHA7 RHOA CAMSAP3 KIFC3 IGF1 NECTIN2 AFDN ROCK1 ACTN1 MET CTNND1 ZYX CYFIP2 PIP5K1C NCKAP1 CDH1 CTNNA1 NCK1 ENAH IGF1R ABI1 DIAPH1 MYL2 EXOC4 EXOC3 CTNNB1 GIT1 EFNA1 VCL ARF6 EGFR AQP5 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 MAP2K2;MAP2K1 FLT1 NOS3 VEGFA PIK3R1 ROCK1 PLCG1 NCK2 PDPK1 PRKCD BRAF PRKACA-1 PIK3CA MAP2K6 PRKCB CALM3;CALM1 MAPK11 SHB ITGB3 NEDD4 CDC42 MAPK1 PTK2B ITGAV MAPK3 AKT1 RHOA HSP90AB1 FYN PTPRJ CDH5 MAPKAPK2 MYOF HGS CBL AKAP1 CAMKK2 PAK2 VTN PTPN2 CAV1 FBXW11 MAPK14 FES PTPN6 SRC PXN GRB10 HSP90AA1 CTNNA1 NCK1 MAP2K3 GAB1 PTPN11 PRKCA DNM2 KDR PTK2 ARF1 GRB2 RAF1 CTNNB1 VCL IQGAP1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation TP53 TAF4B SERPINI1 CDK4 PFKM EIF4G1 ID2-1 SLC2A1 RUVBL1 KAT5 RUVBL2 SNAI1 NPM1-2 FOSL1 NCL-1 BIRC5 MYC EIF4E EP300 MMP9 BAX CCNB1 EIF4A1 TFRC TRRAP ENO1 BMI1 GAPDH-1 MTA1 CCND2 KAT2A PEG10 UBTF RCC1 TK1 DDX18 CAD ACTL6A NME2 CDC25A SUPT3H PIM1 SUPT7L TERT BCAT1 PTMA HSP90AA1 MAX SHMT1 TAF9 RPL11 IREB2 ODC1 CDCA7 MTDH NBN HSPD1 PRDX3 SMAD2;SMAD3 LDHA NME1 MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 CREBBP HUWE1 SMAD4 EIF2S1 LIN28B GPAM POLR3D RIOX2 NDUFAF2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta DUSP16 PAK3 PRKG1 MAP3K3 PAK1 TRAF6 CCM2 RALB FYN MAP3K12 BLK YES1 TAB1 PAK2 LYN MAPK14 FGR HCK DUSP10 SRC RIPK1 DUSP1 DUSP8 MAP2K6 MAP2K3 LCK RALA-1 MAPK11 CDC42 RAC1 MAP2K4 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) MAP2K2;MAP2K1 EPO GSK3B KITLG FER PTPRO MATK PIK3R1 PIK3C2B SPRED2 SPRED1 GRAP2 MAP4K1 STAP1 SH2B3 SH2B2 BAD EPOR JAK2 PDPK1 TEC STAT5A SNAI2 STAT1 STAT3 PIK3CA CRKL MAPK8 MAPK3 AKT1 MITF CBL SOCS1 LYN RPS6KB1 PTPN6 PTEN GRB10 VAV1 HRAS GAB1 FOXO3 BCL2 PTPN11 DOK1 KIT GRB2 SOS1 RAF1 CREBBP SHC1-1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network MAPK9 PTCH1 BMP4 MAPK8 FGF7 GPC3 FURIN SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events BCAR1 VEGFA NOS2 FN1 VCAM1 TNC F13A1 SAT1 CSF2 TGM2 KCNJ15 VEGFC VEGFD ADAM2 SRC ADAM15 PXN ADAM12 ADAM8 PAOX ITGB1 CSF2RA SPP1 RAC1 ITGA9 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining DCLRE1C XRCC4 POLM PNKP PRKDC LIG4 DNTT APTX APLF POLL NHEJ1 XRCC6 XRCC5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) MAP2K2;MAP2K1 APC HGF PTPN1 PRKCI PIK3R1 PLCG1 RAP1B EGR1 NCK2 BAD PDPK1 MET INPPL1 AKT2 MLST8 PRKCZ PIK3CA JUN SNAI1 SH3KBP1 CRKL RPTOR RAPGEF1 DEPTOR AKT1S1 NUMB ARHGEF4 CDC42 RIN2 MAPK8 KPNB1 EPS15 ETS1 PAK4 MAPK1 RANBP9 RANBP10 MUC20 RAC1 MAP2K4 MAPK3 MAP3K1 EIF4EBP1 EIF4E AKT1 RHOA WASL PAK1 BCAR1 PTPRJ HGS CBL RAB5A PAK2 INPP5D PTPN2 MTOR SRC PARD6A PXN RAP1A CDH1 HRAS SH3GL2 CTNNA1 GAB2 NCK1 GAB1 PTPN11 PTK2 GRB2 SOS1 RAF1 CTNNB1 CRK F2RL2 SHC1-1 ARF6 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway MAPK3 GSN PTPN1 EGF WASL PAK1 PIK3R1 PLCG1 NCK2 STAT1 STAT3 PTPN6 PIK3CB SRC PIK3CA PIP5K1C NRAS HRAS NCK1 GAB1 PTPN11 PTK2 KRAS RASA1 GRB2 SOS1 TLN1 GNAI3 MAPK1 SHC1-1 GNAI1 EGFR PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events AKAP13 GRK3 SNX1 GNAO1 GNAZ GNG2 SNX2 GNA12 PRKCG GNAI2 VASP TRPC6 NOS3 F2R RHOA PLCB3 GNB1 ARHGEF1 ARHGDIA PLCB1 PIK3R1 ROCK1 GNA13 GNA14 GNA15 PRKCD GNA11 GNAQ DNM1 PLCB2 PIK3CA ZYX PRKCB F2 PRKCA DNM2 ROCK2 MYL2 PKN1 F2RL2 GNAI3 GNAI1 ARRB1 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events SDCBP CCL5 MMP9 CXCR4 RHOA SDC4 TFPI FGF6 CXCL12 TNFRSF13B LAMA1 LAMA3 THBS1 PRKCD MDK FN1 GIPC1 ACTN1 TNC ADAM12 ITGB1 FGF2 F2 FZD7 PRKCA DNM2 PLG PTK2 FGFR1 ITGA5 RAC1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway TP53 ATR SKP2 CSNK1G3 USP7 CDKN2A CDK2 CSNK1D GSK3B HIPK2 CSNK1G2 CSNK1G1 CSNK1A1 TPTEP2-CSNK1E;CSNK1E ABL1 CHEK1 PRKCD YY1 MAPK9 KAT5 CCNA2-1 RCHY1 MDM2-2 MAPK8 PPP2CB;PPP2CA EP300 AKT1 PRMT5 DYRK2 CSE1L SETD7 UBE2D1 RASSF1 PPP1R13L CHEK2 KAT8 KMT5A KAT2B MAPK14 DAXX RPL23 FBXO11 SMYD2-1 PPM1D PTPA COP1 E4F1 RPL5-1 TRIM28 TTC5 CCNG1 PIN1 MDM4 RPL11 CREBBP HUWE1 ATM CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes IL5 CDK4 ITCH PTPN1 IRF4 TNF CXCL8 PPARG EGR1 EGR2 CSF2 CREM FASLG TBX21 CASP3 DGKA JUNB SLC3A2 E2F1 JUN PTPRK BATF3 IKZF1 POU2F1 GBP2;GBP3;GBP1 NFATC3 GATA3 CTLA4 NFATC2 EGR3 NFATC1 FOS FOXP3 CALM3;CALM1 RNF128 IL2 MAF IL4 FOSL1 IL3 CD40LG IFNG IL2RA PTGS2-2 CBLB PRKCQ EGR4 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events CDH1 CTNNB1 JUP S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway MAPK3 GNAO1 GNAZ IRS1 GNA12 GNAI2 JUN RHOA PAK1 FOS CDH5 GNA13 GNA14 GNA15 MAPK14 MAPK8 GNA11 GNAQ ELK1 GNAI3 MAPK1 S1PR2 GNAI1 RAC1 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 PLCB3 GNB1 PLCB1 PIK3R1 PLCG1 AR CREB1 PLCB2 PLCG2 SRC PIK3CA HRAS FOS PELP1 GNRH1 PTK2 SHBG CDC42 RAF1 GNAI3 MAPK1 GNAI1 RAC1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events TP53 PLK3 CHEK2 CDC25C CCNE1 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 COL1A2 DMTF1 SP1 CDKN2A MMP1 EP300 NOS3 MMP2 CCL13;CCL2 MMP9 FOSL2 CCND1 CXCL8 LAMA3 IL6 CCNA2-1 JUNB JUN NFATC3 NFATC2 ITGB4 NFATC1 JUND FOSL1 TXLNG THBD HMOX1 LIF USF2 PLAUR DCN MGP PLAU IVL ATF4 GJA1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway TP53BP1 SMC1A TERF2 UBE2N YWHAB BLM ABL1 CHEK2 CDC25C COP1 RBBP8 TOP3A KAT5 TRIM28 CDC25A DCLRE1C RAD17 CTBP1 BID XRCC4 MRE11 RAD9A BRCA1 MDM2-2 NBN RAD50 MDC1 ABRAXAS1 RNF8 FANCD2 SMC3 UIMC1 ATM HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha CRADD TRAF1 CHUK TRAF2 TNFRSF1A MAP3K14 CASP7 TNF RELA CASP2 APAF1 DAXX CASP9 NFKB1 FASLG NFKBIA CASP8 CASP6 CASP3 MAP3K5 RIPK1 FADD CD247 BID MAP2K7 CFLAR BCL2 FAS TRADD BIRC3 MAPK8 CYCS-1 BAG4 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling IKBKB CHUK BGN LY96 IRAK4 TICAM1 RHOA IKBKG TIRAP TLR1 VCAN SAA2;SAA1 IRAK1 IRAK2 HSPD1 TLR6 TLR4 S100A9 MYD88 HMGB1-1 S100A8 TLR3 TLR2 CD14 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events JAK1 TNF TGFB1 STAT4 IL12B IL12RB1 EBI3 JAK2 IL27 STAT5A IL27RA IL12A STAT1 IL12RB2 STAT2 STAT3 IL18 TYK2 TBX21 IL6 IL1B IL17A GATA3 IL2 IFNG IL6ST P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling TP53 NTF3 NTRK1 MMP7 YWHAE BDNF TRAF6 PRKCI PIK3R1 BCL2L11 SQSTM1 IRAK1 MAGED1 MYD88 NGFR BAD FURIN PRDM4 ZNF274;ZNF74 SMPD2 CASP9 RIPK2 NSMCE3 MAPK9 MMP3 IKBKB OMG PRKCZ RHOC RHOB PIK3CA CASP3 MAG BEX3 MAGEH1 IKBKG RTN4 NDN LINGO1 SORT1 BEX2;BEX1 MAPK10 ADAM17 PSENEN BIRC2 PSEN1 MAPK8 APH1A CYCS-1 NCSTN APH1B RAC1 CHUK APP AKT1 RHOA ARHGDIA APAF1 PRKACB-1 XIAP DIABLO-1 CASP6 E2F1 PLG NGF BIRC3 SHC1-1 NTF4 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway APC LRP6 PIP5K1B GSK3B CUL3 FZD5 CSNK1G1 RANBP3 WNT3A KLHL12 NKD2 DVL1 AXIN1 DVL2 DVL3 PI4K2A CAV1 CTNNB1 GSK3A PPP2R5A FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway CDH2 MAPK3 FGF23 AKT1 MMP9 CAMK2A PIK3R1 FGF19 SPRY2 CBL PLCG1 RUNX2 STAT5B PDPK1 STAT1 FGFR4 FGFR3 CTNND1 SRC PIK3CA JUN CDH1 GAB1 FRS2 FOS PTPN11 CTTN KLB FGFR1 FGF1 RPS6KA1 NCAM1 PLAUR IL17RD GRB2 PLAU SSH1 SOS1 SDC2 SPP1 FGFR2 PAK4 MAPK1 SHC1-1 PTK2B ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events ACVR1 SMAD1 FKBP1A SMAD9 SMAD5 SMAD4 AMHR2 AMH BMPR2 TLX2 BMP7 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDKN2A CDK6 CCND1 KDM1A KLK3;KLK2 TMPRSS2 CASP8 UBE2I CARM1 PIAS1 MED1 RANBP9 PTK2B HIP1 TGFB1I1 FHL2 UBE3A VAV3 RPS6KA3 CCND3 GSN ZMIZ1 PAWR NKX3-1 APPL1 AKT1 NCOA6 NCOA4 TGIF1-1 LATS2 CTDSP1 PIAS4 CTDSP2 MAK NCOA2 ZNF318 PIAS3 SNURF HNRNPA1-1 FKBP4 KDM3A TMF1 KDM4C-1 PRDX1 PATZ1 SVIL PA2G4 TCF4 AR CMTM2 NRIP1 SRF UBA3 PRKDC BRCA1 PELP1 XRCC6 XRCC5 CTNNB1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes AKT2 CTNND1 SRC PIK3CA ZYX VASP AKT1 RHOA CDH1 CTNNA1 JUP FYN PIK3R1 PLCG1 CTNNB1 CASR FMN1 PIP5K1A AJUBA EGFR RAC1 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events TIMP1 JAK1 MYC AKT1 MITF PIK3R1 PIAS3 SOCS3 FOXO1-1 JAK2 PRKCD MAPK14 STAT1 HCK STAT3 CRP HSP90B1 TNFSF11 TYK2 LBP A2M BCL2L1 MCL1 IL6 FGG PTPRE PIK3CA CEBPB IRF1 JUNB JUN VAV1 GAB2 MAP2K6 GAB1 FOS PTPN11 MAPK11 IL6R PIAS1 LMO4 GRB2 IL6ST SOS1 CEBPD RAC1 MAP2K4 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA3 EFNA5 EPHA2 EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway ATR PPP2CB;PPP2CA CDK2 YWHAB PPP2R1A CLSPN BTRC BRCA2 CHEK1 FBXW11 ATRIP PLK1 YWHAZ CDC25C RFC5 RFC3 RFC4 RFC2 RPA1 CDC25A CCNA2-1 RPA2 SMARCAL1 HUS1 MCM7 CEP164 TIPIN RAD17 CDC6 RAD1 PPP2R2B TIMELESS RAD9A MCM2 MDM2-2 NBN TOPBP1 RAD51 FANCD2 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin APC LRP6 CSNK1D GSK3B FZD5 CSNK1A1 CUL1 WNT3A SKP1 DVL1 BTRC AXIN1 AXIN2 DVL2 TPTEP2-CSNK1E;CSNK1E DVL3 CTNNB1 GSK3A IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway YWHAE AKT1 PTPN1 IGF1 BCAR1 PIK3R1 NCK2 RACK1 BAD PDPK1 PRKCD YWHAZ RPS6KB1 PRKCZ IRS1 PIK3CA PXN IRS2 GRB10 HRAS PTPN11 PRKD1 IGF1R PTK2 CRKL GRB2 SOS1 RAF1 CRK SHC1-1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K2;MAP2K1 MAPK3 IL1B MAP2K7 MAP2K3 MAP2K6 CALM3;CALM1 TNF ANTXR2 CASP1 ANTXR1-1 NLRP1 PGR VCAM1 IL18 MAPK1 MAP2K4 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods RPE65 GRK1 RDH12 RGS9BP RDH5 GNB1 LRAT GNB5 RGS9 LOC118142757;GUCA1A SLC24A1 GNGT1 RHO SAG CNGA1 PDE6B PDE6A GNAT1 CNGB1 GUCY2D GUCA1C FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network FOXM1 MAP2K2;MAP2K1 CENPB BIRC5 CKS1B SKP2 CDK4 NEK2 SP1 GAS1 MYC CDKN2A H2BC1 XRCC1 CDK2 EP300 MMP2 CENPF CCNB1 CCND1 RB1 BRCA2 CHEK2 PLK1 CDC25B GSK3A CCNA2-1 ETV5 CDK1 NFATC3 FOS CENPA CCNB2 AURKB CREBBP HSPA1A;HSPA1B CCNE1 LAMA4 ESR1 ONECUT1 TGFA IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events GRK2 GNG2 PRKCG GNAI2 CXCR1 AKT1 PLCB3 GNB1 PLCB1 CXCL8 ARRB2 CBL PLD1 RAB5A GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 PRKCB PRKCE PRKCA ARRB1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions SPON2 ICAM2 ICAM3 ICAM4 F11R THY1 FGB FGA F10 GP1BA PROC TGFBI KNG1 VCAM1 FGG C3-1 CCN1 ITGAM ITGB2 PLAT ITGAL ITGAX ICAM1 CD40LG JAM3 PLAUR ITGAD PLAU INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport STX4 YWHAE AKT1 GSK3B INSR YWHAB PRKCI YWHAQ SFN YWHAG YWHAH ASIP PPP1R3A GYS1 LNPEP TRIP10 VAMP2 YWHAZ RHOQ AKT2 PRKCZ SLC2A4 TBC1D4 CALM3;CALM1 STXBP4 PPP1CC INS;INS-IGF2 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway MAP2K2;MAP2K1 PAG1 PIK3R1 AFDN RAP1B SPHK1 ABL1 NCK2 JAK2 STAT5A STAT1 S1PR1 STAT3 PIK3CB PIK3CA CYFIP2 NCKAP1 WASF2 MAP2K7 MAPK10 CTTN ABI1 RAPGEF1 ITGB3 MAPK8 MAPK1 ITGAV MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA EIF2AK2 RHOA ARPC1B PAK1 BCAR1 ARHGDIA PPP2R1A BLK PTPRJ ACTR2 ARPC4 ARPC5 PTPN2 BAIAP2 ARPC2 LYN ARPC3 ACTR3-1 FGR HCK SRF PTEN SRC RAP1A GRB10 HRAS PPP2R2B NCK1 GAB1 PTPN11 PRKCA DOK1 RASA1 GRB2 SOS1 CRK SHC1-1 CSK YWHAE PTPN1 YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PRKCD BRAF YWHAZ USP6NL ELK1 SLA ACTN4 SLC9A3R2 SLC9A3R1 RAB4A DOCK4 MAPK9 MYOCD ARAP1 ACTA2 SIPA1 JUN NRAS FOS PRKCE JUND KRAS VAV2 MYC PLA2G4A WASL FYN YES1 CBL RAB5A STAT5B PIK3CG PIK3R6 EPS8 PIN1 LCK LRP1 ARHGAP35 DNM2 PDGFRB RAF1 PDGFB IQGAP1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVR1 FKBP1A ACVRL1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway NECTIN2 PIK3R1 F11R AFDN RAP1B SRC PIK3CA PTPRM CLDN1 PVR RAP1A PIP5K1C CDH1 NECTIN3 CTNNA1 NECTIN1 PTK2 PDGFRB RAPGEF1 ITGB3 CDC42 CTNNB1 TLN1 VAV2 CRK PDGFB FARP2 IQGAP1 ITGAV RAC1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway MAP2K2;MAP2K1 PAG1 CSK TRAF6 PIK3R1 RELA MAP4K1 PDPK1 ELK1 DAPP1 BLNK NFKB1 PLCG2 NFKBIA IKBKB PIK3CA JUN IKBKG PPP3CB PPP3CC CARD11 NFATC1 FOS BCL2A1 BCL10 CALM3;CALM1 MALT1 BTK CD79B CAMK2G CD79A CD19 SH3BP5 CD72 IBTK PTPRC CD22 MAPK8 NFKBIB VAV2 ETS1 MAPK1 RAC1 MAPK3 POU2F2 MAP3K1 SYK CHUK AKT1 INPP5D LYN MAPK14 CSNK2A1;CSNK2A3 PPP3CA PTPN6 PTEN HRAS MAP3K7 DOK1 RASA1 GRB2 SOS1 RAF1 SHC1-1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity AKAP13 ARHGEF10 VAV3 FARP1 NGEF ARHGEF12 ARHGEF17 ARHGEF11 PLEKHG6 ARHGEF28 ARHGEF18 MYO9B TRIO NET1 RHOA DLC1 ARHGEF3 ARHGAP5 ARHGEF1 ARHGEF5 ARHGDIA ARHGDIB ECT2 CDKN1B ARHGAP9 ARAP1 ABR ARAP3 DEF6 VAV1 BCR ARHGEF2 ARHGAP35 ARHGEF25 ARHGEF15 ARHGDIG ARHGEF10L MCF2L VAV2 ARHGAP6 ARHGAP4 OPHN1 ARHGAP8;PRR5-ARHGAP8 MCF2 SRGAP1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin STXBP1 RAB3GAP2 STX1A VAMP2 CHRNA1 UNC13B SNAP25 RIMS1 SYT1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway SKP2 CCND1 NOTCH1 KDM1A MAML2 MAML1 RBPJ FURIN YY1 DNM1 RBBP8 SPEN ADAM12 NCOR2 IL4 PSENEN NUMB APH1A FBXW7 NCSTN EPS15 CDKN1A APH1B ITCH MYC EP300 CBL BTRC DNER ADAM10 NOTCH2 NOTCH3 ENO1 NOTCH4 DTX1 DLL1 DLL3 DLL4 MARK2 JAG2 NCOR1 JAG1 CNTN6 MYCBP-1 DLK1 MIB1 MFAP5 MFAP2 NEURL1 CNTN1 HDAC1 LNX1 CTBP1 PTCRA GATA3 CUL1 SKP1 RAB11A GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network MDK GPC2 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 JAK1 ELF1 CCND3 SP1 MYC LTA CDK6 PIK3R1 IL2RG STAT5B STAT5A CCND2 PRF1 FASLG BCL2L1 CCNA2-1 PIK3CA GAB2 LCK IL2RB FOXP3 BCL2 PTPN11 IL2 IL4 IL2RA GRB2 SOS1 SHC1-1 JAK3 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events MAP2K2;MAP2K1 MAPK3 AKT1 CHRNA1 PIK3R1 BAD JAK2 MTOR STAT3 MAPK9 PIK3CB SRC PRKACA-1 PIK3CA JUN NRAS DOCK7 HRAS PPP3CB ERBB3 ERBB2 CHRNE USP8 FOS NRG2 RNF41 NFATC4 MAPK10 PTPN11 NF2 KRAS CDC42 MAPK8 GRB2 SOS1 RAF1 MAPK1 SHC1-1 RAC1 NRG1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events PPP2CB;PPP2CA GNG2 PRKCG GNAI2 VASP AKT1 PLCB3 GNB1 PLCB1 PPP2R1A CXCL8 ARRB2 CBL RAB5A PLD2 ELMO1 GNA14 LYN PDPK1 GNA15 PIK3CG PIK3R6 FGR HCK DNM1 PLCB2 DOCK2 PRKCB CXCR2 PRKCA RAB7A RAB11A ARRB1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA1 FOXA3 FOXA2 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC3 SDC1 SDC2 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions COL1A2 COL1A1 VEGFA SDC4 F11R COL4A1 THY1 FGB FGA LAMB1 COL4A4 VTN TGFBI SPHK1 COL4A3 COL4A6 THBS1 SDC1 COL4A5 FN1 TGFBR2 TNC FGG PVR CCN1 ITGA2B KDR HMGB1-1 PDGFRB ITGB3 IBSP EDIL3 PLAUR L1CAM PECAM1 PLAU CD47 SPP1 FBN1 PDGFB LAMA4 ITGAV LAMC1 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events MAP2K2;MAP2K1 CDK2 PIK3R1 CISH SOCS3 STAT5A STAT1 STAT3 MAPK9 PIK3CA JUN NRAS FOS PRKCB PRKCE IL2 MAPK11 KRAS IFNG IL2RA MAPK8 MAPK1 PTK2B JAK3 JAK1 MAPK3 MYC SYK DOK2 RHOA FYN MAPKAPK2 IL2RG SOCS1 STAT5B MAPK14 IRS1 IRS2 HRAS GAB2 LCK IL2RB BCL2 PTPN11 RASA1 GRB2 SOS1 RAF1 IKZF3 STAM2 SHC1-1 SOCS2 STAM GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC2 GPC3 GPC1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway NONO NR1D1 ATR NPAS2 ARNTL PER2 PER1 CRY2 CRY1 WDR5 CLOCK TIMELESS TPTEP2-CSNK1E;CSNK1E BHLHE40 CHEK1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events CD8B;CD8B2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CCR5 IL1R1 CCL3L1;CCL3L3;CCL3;CCL18 CD3E RELB CCL4L2;CCL4L1;CCL4 HLX RELA GADD45B GZMA IL18RAP NFKB2 STAT4 GADD45G IL12B IL12RB1 JAK2 STAT5A NOS2 IL12A STAT1 IL12RB2 STAT3 IL18 CD3G CD3D RIPK2 TYK2 NFKB1 FASLG TBX21 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD4 IL1B HLA-DRA CD247 IL18R1 MAP2K6 FOS IL2 IL4 IFNG IL2RA ATF2 SPHK2 IL2RG SOCS1 STAT6 MAPK14 MTOR MAP2K3 LCK IL2RB RAB7A B2M GZMH;GZMB-1 EOMES CD8A BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions CCN1 MADCAM1 TGFBR1-1 VTN ITGB8 ITGB7 ITGB6 ITGA4 SDC1 EDIL3 PLAUR FN1 PLAU FBN1 VCAM1 ITGB5 ITGAV INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis COL1A2 COL1A1 COL3A1 COL2A1 IGF1 VEGFA COL5A1 F11R COL4A1 PIK3R1 COL4A4 ROCK1 COL7A1 CDKN1B COL6A2 COL6A1 COL5A2 COL4A3 PIK3C2A COL4A6 ADGRA2 SDC1 ANGPTL3 COL4A5 COL6A3 MFGE8 FN1 PI4KA PI4KB CASP8 PIK3CA ITGB3 ILK SPP1 MAPK1 PTK2B ITGAV RAC1 MAPK3 VAV3 AKT1 RHOA BCAR1 CBL VTN TGFBR2 RPS6KB1 IRS1 SRC PXN HSP90AA1 FGF2 PTPN11 IGF1R KDR PTK2 EDIL3 CSF1R TLN1 VCL CSF1 COL11A1 COL11A2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III FHL2 TP53 EP300 BAX HDAC4 FOXO4 SIRT1 FOXO3 SIRT2 PPARGC1A SIRT3 XRCC6 FOXO1-1 KAT2B CREBBP ACSS2 CDKN1A TUBB2B;TUBB2A HOXA10 H1-4 ACSS1 MYOD1 MEF2D RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling MAPK3 RARA RARB PRKCG EP300 AKT1 NCOA1 NCOA2 NCOA3 HDAC3 MAPK14 KAT2B NRIP1 CCNH CDK7 RBP1 MNAT1 PRKACA-1 RXRB CDK1 RXRA HDAC1 NCOR2 RXRG PRKCA RARG MAPK8 CREBBP MAPK1 VDR HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha TP53 NAA10 CDKN2A CUL2 ARNT HIF3A RBX1 HSP90AA1 OS9 ELOC-1 COPS5 ELOB VHL HIF1AN EGLN1 EGLN3 EGLN2 RACK1 HIF1A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network SP1 COL18A1 NKX3-1 EP300 DSCAM NCOA3 AP1B1 CDKN1B VTN TFF1 PRDM15 AR NRIP1 KLK3;KLK2 NDUFV3 ATP5PF XBP1 CEBPB JUN SERPINA1 POU2F1 C4BPB SOD1 CYP2C18-1 SFTPD BRCA1 GCG FOS NR2F2 PISD NFIA NFIB FOXA1 NFIC SCGB1A1 FOXA3 FOXA2 APOB CREBBP ESR1 SHH INS;INS-IGF2 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway RHOA CAMK2A YES1 TAB2 CSNK1A1 TAB1 ROCK1 ARRB2 PPARG MAPK9 PRKCZ CTHRC1 MAP3K7 FZD2 FZD5 NFATC2 MAPK10 FZD7 DVL1 DVL2 FZD6 DVL3 WNT5A CHD7 FLNA SETDB1 CDC42 DAAM1 MAPK8 ROR2 NLK RAC1 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling GNAO1 GNAZ GNG2 GNAI2 NOS3 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 IGF1 BCAR1 PLCB1 PIK3R1 GNA13 GNA14 GNA15 GNA11 GNAQ PLCB2 SRC PIK3CA NRAS HRAS ESR2 PELP1 MSN MAPK11 IGF1R KRAS ROCK2 HBEGF GNAL GRB2 STRN SOS1 GNAI3 SHC1-1 GNAI1 ESR1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription APC CDKN2A ID2-1 YWHAE TCF7L2 YWHAB VCAN CCND1 YWHAQ CXCL8 SFN YWHAG YWHAH SNAI2 YWHAZ CAMK4 RUVBL2 TLE1 JUN XPO1 TBXT DVL3 INCENP TCF7L1 ZCCHC12 CHD8 CBY1 FGF4 MED12 SALL4 PITX2 TLE4 MYOG TLE2 MYC KRT1 CTNNBIP1 EP300 MMP2 TLE5 MMP9 DKK4 MDFIC MITF TBL1XR1 TNIK TCF7 ADCY7 NCOA2 CACNA1G IGF2BP1 HBP1 CDX4 BTRC CDX1 AXIN2 KCNIP4 KLF4 SMARCA4 BCL9 SP5 TRRAP NEUROG1 MYF5 TCF4 AR CCND2 HDAC2 TERT HDAC1 CDH1 CCN1 CTBP1 CUL1 SKP1 DKK1 CTNNB1 LEF1 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway EPO PIK3R1 CBL PLCG1 SOCS3 INPP5D SH2B3 EPOR JAK2 LYN STAT5B TEC STAT5A MAPK14 STAT1 NFKB1 PTPN6 PLCG2 BCL2L1 IRS2 RAP1A HRAS GAB1 BCL2 PTPN11 BTK CRKL RAPGEF1 MAPK8 GRB2 SOS1 VAV2 SHC1-1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway MAP3K1 TXN TRAF2 MAP3K3 TRAF6 CCM2 TAB2 TAB1 GADD45B GADD45G MAP3K6 MAPK14 MAP3K4 TAOK3 TAOK1 TAOK2 CAMK2B MAP3K10 MAP3K5 MAP3K7 MAP2K6 MAP2K3 CALM3;CALM1 MAPK11 GADD45A RAC1 ATM C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway PPP2CB;PPP2CA SKP2 MYC CDKN2A GSK3B HBP1 PAK2 RUVBL1 TRRAP KAT2A PML ACTL6A KAT5 RUVBL2 SUPT3H PIN1 SUPT7L MAX TAF9 AXIN1 TAF12 ZBTB17 TAF10 FBXW7 PPP2R5A S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway MAPK3 GNAO1 GNAZ GNAI2 RHOA VEGFA PLCG1 KDR ABCC1 PDGFRB SPHK1 PTGS2-2 S1PR1 PDGFB GNAI3 MAPK1 GNAI1 PLCB2 RAC1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network FLT1 APP FYN VEGFA BLK YES1 TGFBR1-1 LAMA1 TGFB1 TGFB3 LYN FGR HCK TGFBR2 SERPINC1 PLA2G2A-1 SLIT2 PRNP TDGF1 SRC LCK FGF2 SMAD2;SMAD3 FGFR1 GPC1 NRG1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins MAP2K2;MAP2K1 EDN1 COL1A2 GNAO1 GNAZ GNA12 MMP1 GNAI2 COL3A1 GNA14 JAK2 PRKCD GNA15 GNA11 GNAQ JUN FOS PRKCB PRKCE CDC42 MAPK8 GNAL MAPK1 PTK2B RAC1 MAPK3 PRKCG TRPC6 AKT1 PLA2G4A RHOA PLCB3 BCAR1 PLCB1 ADCY7 MAPK14 PLCB2 SLC9A1 EDNRA SRC CYSLTR1 CYSLTR2 EDNRB PRKCH HRAS EDN2 EDN3 ADCY9 ADCY4 ADCY3 ADCY2 ADCY1 PRKCA ADCY8 ADCY6 ADCY5 SLC9A3 RAF1 CRK GNAI3 PRKCQ GNAI1 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network KDR VEGFC VEGFD NRP1 NRP2 FLT1 FLT4 VEGFB PGF VEGFA NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte TRPC6 AKT1 WASL PRKCI FYN PIK3R1 ARRB2 PLCG1 NCK2 BAD MAPK9 PIK3CB PRKCZ PARD6A PIK3CA JUN NCK1 TJP1 MAPK10 MAPK8 KIRREL1 GRB2 CD2AP NPHS1 F2RL2 NPHS2 RAC1 MAP2K4 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events LPAR4 GNAO1 GNAZ GNA12 GNAI2 GSK3B PIK3R1 TRIP6 CXCL8 RELA PLCG1 GNA14 PRKCD GNA15 GNA11 GNAQ SLC9A3R2 NFKB1 PIK3CB NFKBIA CASP3 JUN FOS PRKCE TIAM1 HBEGF MAPT PTK2B RAC1 GNG2 MMP2 AKT1 MMP9 RHOA PLCB3 GNB1 ARHGEF1 BCAR1 ADCY7 PLD2 GNA13 LYN SRC PXN HRAS ADCY9 GAB1 ADCY4 ADCY3 ADCY2 PRKD1 ADCY1 ADCY8 ADCY6 PTK2 ADCY5 CRK ADRA1B GNAI3 LPAR1 GNAI1 LPAR2 EGFR LPAR3 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions NPNT COL1A2 NID1 CSPG4 COL1A1 COL3A1 COL2A1 LAMB3 LAMA2 VEGFA COL5A1 COL4A1 LAMB2 LAMC2 FGB FGA COL4A4 LAMB1 COL7A1 COL6A2 COL6A1 LAMA1 COL5A2 TGFBI COL4A3 LAMA3 COL4A6 COL4A5 COL6A3 FN1 ITGA3 TNC F13A1 TGM2 ITGB1 ITGA4 ITGA2 ITGA1 PLAU ITGA10 SPP1 ITGA11 ITGA8 ITGA7 ITGA6 ITGAV ITGA5 LAMC1 ITGA9 COL18A1 IGSF8 VTN CD81 THBS2 THBS1 MDK CD14 JAM2 VCAM1 FGG PLAUR FBN1 LAMA5 LAMA4 COL11A1 COL11A2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ELANE FPR1 KLK4 VLDLR HGF FPR2 MMP9 PDGFD CTSG CTRC-2 BCAR1 MMP12 MMP13 FGB GPLD1 FGA VTN TGFB1 DOCK1 FN1 ITGA3 MMP3 FGG SRC ITGB1 ITGAM ITGB2 LRP1 PLG PDGFRB ITGB3 PLAUR PLAU CRK ITGB5 SERPINE1 EGFR ITGAV NCL-1 ITGA5 RAC1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CCL5 COL1A2 SP1 ID2-1 CCND1 GFI1 CLU CDKN1B FTH1 HMGCS2 TBP SLC11A1 DNMT3A TSC2 SFRP1 TMEFF2 CSDE1 ALDH9A1 GTF2H2C;GTF2H2C_2;GTF2H2 NDRG2 NDRG1 ZFP36L1 NFYB NFYC TMEM126A-1 S100A7A;S100A7 SFXN3 NFYA-1 TJP2 MXD4 ITGB1 DDIT3 ERBB2 LGALS1 ITGB4 DNTT CFLAR GADD45A IRF8 SPI1 CDKN1A ITGA6 MYC EP300 HDAC3 CREB1 RBL1 PTPA HDAC1 MAX BRCA1 FOXO3 BCL2 SMAD2;SMAD3 PDGFRB WNT5A ZBTB17 CDKN2B DKK1 CEBPA SMAD4 CEBPD ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network AREG EGF HSP90AA1 ERBB4 ERBB3 ERBB2 NRG2 EREG BTC NRG3 NRG4 HBEGF EGFR TGFA NRG1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II NR3C1 GRK2 HDAC10 GNG2 HDAC11 YWHAE YWHAB GNB1 MEF2C HDAC5 HDAC3 GATA2 HDAC9 HDAC6 GATA1 HDAC7 CAMK4 TUBB2B;TUBB2A BCL6 SRF RFXANK NCOR2 HSP90AA1 BCOR ANKRA2 RANBP2 HDAC4 UBE2I XPO1 SUMO1 RANGAP1 RAN ESR1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling YWHAE CAMK2A TAB2 TAB1 NEDD4L PDPK1 ZFYVE9 DACT2 RNF111 TGFBR3 ZFYVE16 STRAP PPP2R2A;PPP2R2D AXIN1 PPP1R15A TGFBRAP1 FKBP1A OCLN-1 YAP1-1 SPTBN1 SMURF2 DAB2 BAMBI DYNLRB1 EIF2A WWP1 PPP2CB;PPP2CA ITCH TGFBR1-1 ARRB2 TGFB1 TGFB3 CAV1 DAXX XIAP TGFBR2 SMURF1 PPP1CA RPS6KB1 PML PARD6A MAP3K7 SMAD2;SMAD3 CCN2 GRB2 SOS1 CTNNB1 SMAD4 SHC1-1 SMAD7 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions ITGB7 CDH1 ITGAE JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAP3K1 LCP2 JUN MAP3K7 PRKCB LAT GRAP2 MAP4K1 CRKL MAPK8 DBNL CRK MAP3K8 MAP2K4 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAE GSK3B YWHAB YWHAQ CSNK1A1 SFN YWHAG YWHAH BAD PRKCD YWHAZ CAMK4 MAP3K8 MEF2D MAPK9 AKAP5 PRKCZ CABIN1 PRKACA-1 CASP3 CHP1 NFATC3 NFATC2 NFATC1 XPO1 PRKCB CALM3;CALM1 PRKCE RAN FKBP1A RCAN1 MAPK8 RCAN2 KPNB1 KPNA2 NUP214 FKBP8 NR4A1 MAPK3 MAP3K1 PRKCG EP300 BAX MAPK14 CSNK2A1;CSNK2A3 BCL2L1 PIM1 PRKCH BCL2 PRKCA CREBBP PRKCQ TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells LCP2 PAG1 CSK TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 MAP4K1 PDPK1 CD86 MAP3K8 CD80 CD3G CD3D RASGRP2 IKBKB HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RASGRP1 CD4 CD28 ZAP70 HLA-DRA IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS FLNA PTPRC CDC42 DBNL SLA2 RASSF5 STIM1 ORAI1 WAS STK39 SH3BP2 FYB1 CHUK AKT1 MAP3K14 FYN CBL INPP5D PTPN6 PTEN RAP1A VAV1 HRAS GAB2 NCK1 LCK PTPN11 PRKCA GRB2 SOS1 ITK SHC1-1 PRKCQ VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals MAPK3 FLT1 NOS3 AKT1 VEGFA PIK3R1 SHC2 CBL PLCG1 CAV1 PDPK1 HIF1A PRKACA-1 PIK3CA HSP90AA1 NCK1 PRKCB CALM3;CALM1 PTPN11 PRKCA NRP1 NRP2 VEGFB RASA1 PGF CD2AP MAPK1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events EDN1 EDNRA EGF GRB2 SOS1 HRAS MTOR SHC1-1 EGFR HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins MAP2K2;MAP2K1 SMO SIN3B GNAO1 GNAZ GNG2 SIN3A CSNK1G3 IFT172 GLI1 GNAI2 CSNK1D GLI3 AKT1 GSK3B STK36 KIF3A GNB1 CSNK1G2 RAB23 CSNK1G1 SPOP MTSS1 CSNK1A1 IFT88 ARRB2 BTRC TPTEP2-CSNK1E;CSNK1E FBXW11 SAP30 PRKCD HDAC2 PRKACA-1 LGALS3 HDAC1 XPO1 RBBP4 SAP18 RBBP7 PIAS1 FOXA2 PTCH1 CREBBP GNAI3 GNAI1 GLI2 SHH INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway SGK1-1 EIF4EBP1 AKT1 PTPN1 INSR PRKCI PIK3R1 SORBS1 CBL INPP5D NCK2 SH2B2 CAV1 PDPK1 TRIP10 RHOQ RPS6KB1 PTPRA AKT2 PRKCZ IRS1 PARD6A PIK3CA GRB10 HRAS NCK1 EXOC7 FOXO3 PTPN11 GRB14-1 DOK1 RAPGEF1 RASA1 EXOC4 EXOC3 GRB2 SOS1 EXOC6 CRK F2RL2 EXOC5 EXOC2 SHC1-1 INS;INS-IGF2 EXOC1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFRB PDGFRA PDGFD PDGFA PDGFB PDGFC EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling VAV3 EPHA2 SRC PIK3CA RHOA PAK1 BCAR1 PIK3R1 CBL ARHGAP35 TIAM1 ACP1 PTK2 GRB2 VAV2 EFNA1 INPPL1 SHC1-1 RAC1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling MAP2K2;MAP2K1 EGF PIK3R1 STAT1 STAT3 MAPKAP1 PIK3CB MLST8 RICTOR PIK3CA CYFIP2 NCKAP1 WASF2 ABI1 CDC42 MAPK8 MAPK1 MAP2K4 RAC1 KSR1 MAPK3 RPS6KA3 PPP2CB;PPP2CA MAP3K1 ARPC1B PPP2R1A ACTR2 PLD1 SMAD1 PLD2 ARPC4 ARPC5 BAIAP2 ARPC2 ARPC3 ACTR3-1 SRF SLC9A1 SRC HRAS GAB1 PRKCA GRB2 SOS1 F2RL2 CAPN2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH EGR1 BAD PDPK1 PRKCD BRAF YWHAZ USP6NL ELK1 MAPK9 PRKCZ JUN DUSP1 NRAS PEBP1 FOS CALM3;CALM1 PPP2R2A;PPP2R2D KRAS RIN1 ATF2 VAV2 ATF1 RPS6KA4 RPS6KA5 AKT1 WASL MEF2C RAB5A ARF4-1 ZFP36 RALGDS MAP2K5 MYLPF PPP5C DIAPH3 DUSP6 MAPK7 MAP3K2 MTOR CREB1 BCL2L1 EPS8 CHN2 RPS6 RALA-1 RAF1 IQGAP1 EGFR LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development VLDLR YWHAE RHOA DYNLT1 MAP1B NUDC ABL1 LRP8 PLA2G7 RELN CSNK2A1;CSNK2A3 KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 CDK5R2 PAFAH1B2 CDK5R1 PAFAH1B1 CALM3;CALM1 LRPAP1 CDC42 PPP2R5D IQGAP1 CDK5 RAC1 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL MAPK3 RHOC SRC CCNA2-1 CDK2 RHOA RABGGTB AGT ITGB1 RABGGTA BCAR1 PTP4A2 PTP4A3 PTP4A1-1 ATF5 ROCK1 EGR1 ITGA1 CDKN1A CCNE1 MAPK1 RAC1 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling PTPN13 FYN BLK PIK3R1 YES1 EFNB2 NCK2 EFNB1 LYN EPHB2 EPHB1 EPHB4 FGR HCK DNM1 SRC PIK3CA MAP3K7 LCK ITGA2B RGS3 TIAM1 ITGB3 MAPK8 RAC1 MAP2K4 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium MAPK3 COL1A2 AKT1 COL1A1 PIK3R1 FN1 MAPK14 CREB1 VEGFC VEGFD PIK3CA ITGB1 MAPK11 FLT4 ITGA4 RPS6KA1 ITGA2 ITGA1 GRB2 SOS1 CRK MAPK1 SHC1-1 ITGA5 MAP2K4 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events EPHA2 HGF EGF ARRB2 GNA14 GNA15 GNA11 GNAQ MET CYTH3 CYTH2 SRC PXN ADRB2 ADAP1 NCK1 ITGA2B TSHR KIF13B FBXO8 LHCGR IQSEC1 ACAP1 ARAP2 ITGB3 IPCEF1 AGTR1 GULP1 ACAP2 GIT1 EFNA1 ARF6 EGFR ARRB1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network AEN CCNE2 NDUFS2 HAGH NTRK1 SP1 PFDN5 PLPP1 FBXO45 CDK2 AFP GRAMD4 HSF1 CLCA2 BUB3 CDK6 BAK1 BCL2L11 DEDD GDF15 RB1 NSG1 ADA SFN TP53I3 RELA WT1 TP73 DCP1B BRCA2 NEDD4L ABL1 RACK1 CHEK1 GATA1 HEY2 KAT5 CCNA2-1 RCHY1 SERPINA1 WWOX MDM2-2 MAPK11 FAS YAP1-1 CDKN1A SERPINE1 JAK1 IL4R ITCH MYC TP63 PLK3 FASN EP300 BAX CCNB1 SIRT1 CASP2 BUB1 PRKACB-1 PLK1 MAPK14 JAG2 PML PIN1 CDK1 FOXO3 BIN1 IL1RAP BBC3 TUBA1A PEA15 RAD51 FLOT2 RNF43 S100A2 UBE4B CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events MAP2K2;MAP2K1 MAPK3 GNAO1 GNAZ GNG2 GNAI2 AKT1 CXCL9 GNB1 CCL11 PIK3R1 CXCL13 CXCR3 PF4;PF4V1-1 PDPK1 CXCL10 CXCL11 MAPK14 MTOR DNM1 MAPKAP1 PIK3CB MLST8 RICTOR SRC PIK3CA NRAS HRAS MAP2K6 MAP2K3 MAPK11 KRAS RAF1 GNAI3 MAPK1 GNAI1 ARRB1 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events PIK3R1 CISH YWHAG CSF2RB INPP5D PRKACB-1 JAK2 STAT5B STAT5A SRP9 YWHAZ CNKSR1 IL3RA ID1 BCL2L1 PRKACA-1 PIK3CA CEBPB PIM1 HDAC1 GAB2 PTPN11 IL3 OSM GRB2 SHC1-1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling GNA12 GNAI2 NOS3 PRKG1 EGF ROCK1 GNA14 PRKCD GNA15 GNA11 GNAQ PTGDR PTGIR DNM1 TBXA2R SLC9A3R1 TGM2 PRKCZ PRKACA-1 PRKCB PRKCE MAPK11 SELE RAC1 GRK2 GRK3 GNG2 SYK PRKCG AKT1 RHOA GNB1 ARHGEF1 FYN BLK YES1 ARRB2 GNA13 LYN PIK3CG MAPK14 FGR PIK3R6 HCK VCAM1 PLCB2 ARR3 SRC PRKCH LCK GNB5 PRKCA ICAM1 RAB11A PRKCQ EGFR A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling IL1A MST1 YWHAE AKT1 EGF YWHAB LAMB3 LAMA2 PIK3R1 CASP7 LAMB2 LAMC2 YWHAQ LAMB1 SFN YWHAG LAMA1 YWHAH LAMA3 YWHAZ MET RPS6KB1 COL17A1 PMP22 CD9 PIK3CA RXRB RXRA CDH1 RXRG HRAS ITGB1 ERBB3 ERBB2 ITGB4 MST1R PRKCA GRB2 SHC1-1 LAMA5 LAMA4 ITGA6 EGFR LAMC1 RAC1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway MAP2K2;MAP2K1 SGK1-1 CDK2 YWHAE YWHAB YWHAQ SFN YWHAG YWHAH TSC2 PDPK1 YWHAZ BRAF YY1 MAPKAP1 PRR5 IKBKB RB1CC1 MLST8 TSC1 RICTOR ATG13 RRAGA RRAGC RRAGB RRAGD NRAS DDIT4 ULK2 ULK1 RRN3 POLDIP3 PPARGC1A EIF4B BNIP3 EEF2 RHEB PDCD4 RPTOR KRAS DEPTOR AKT1S1 RPS6KA1 EEF2K SREBF1 CYCS-1 MAPK1 MAPK3 EIF4EBP1 EIF4E AKT1 PLD1 BTRC PLD2 EIF4A1 FBXW11 MTOR RPS6KB1 PML CLIP1 IRS1 HRAS PRKCA RAF1 CCNE1 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway BTRC NFKB1 NFKB2 CHUK MAP3K14 RELB DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors SP1 AFP VCAN BAK1 GDF15 RB1 TP53I3 TP73 MAP4K4 CASP10 DDIT4 BID MDM2-2 FAS STEAP3 CCNK PRDM1 PYCARD SESN1 FDXR BNIP3L TAP1 SPP1 PRKAB1 HIC1 MSH2 CTSD TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DDX5 PCBP4 TP53BP2 SCN3B BCL2L14 TP63 SH2D1A PLK3 TADA2B COL18A1 RGCC MMP2 CD82 JMY BCL2L2 BTG2 BAX CCNB1 PPP1R13B CX3CL1 AIFM2 DGCR8 ZNF385A GPX1 PRMT1 DDB2 RNF144B SMARCA4 RRM2B CAV1 IRF5 TYRP1 TRRAP HTT RPS27L PPM1J NLRC4 TP53INP1 E2F2 DROSHA PMS2 TIGAR PML ARID3A MLH1 CEBPZ MCL1 PTEN POU4F1 POU4F2 EDN2 TAF9 PCNA PMAIP1 E2F3 HSPA1A;HSPA1B TGFA TP53 APC HGF SFN TSC2 SNAI2 MET NDRG1 NFYB NFYC NFYA-1 RCHY1 DUSP5 JUN DUSP1 SERPINB5 BCL2A1 CARM1 GADD45A PERP BDKRB2 IGFBP3 CDKN1A SERPINE1 EPHA2 EP300 PIDD1 CASP1 CSE1L APAF1 KAT2A TFDP1 BCL6 COP1 ATF3 BCL2L1 CASP6 CCNG1 HDAC2 E2F1 BCL2 FOXA1 LIF DKK1 CREBBP BBC3 VDR S100A2 EGFR LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events LPAR4 RPS6KA5 PRKACA-1 ADCY9 ADCY4 ADCY7 ADCY3 ADCY2 PRKCE ADCY1 ADCY8 ADCY6 ADCY5 GNAL CREB1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly CDH2 SNX1 GNA12 NTRK2 MMP7 PTPN1 EGF BDNF FYN HGS RAB5A ABL1 ADAM10 GNA13 MET PTPN6 RET MMP3 ROBO1 CTNND1 SLIT1 SRC DSP CASP3 IGF2 CABLES1 ZBTB33 CDH1 MEP1B CTNNA1 HRAS CBLL1 JUP GFRA1 TIAM1 IGF1R DNM2 RAB7A NME1 GDNF CDC42 RIN2 CREBBP CTNNB1 IQGAP1 ARF6 EGFR RAC1 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling TP53 BIRC5 TACC1 ARHGEF7 AURKA AKT1 GSK3B PAK1 FZR1 CDC25B AJUBA NDEL1 CKAP5 TPX2 NFKBIA PRKACA-1 TACC3 OAZ1 DLGAP5 TDRD7 BRCA1 CPEB1 CENPA AURKAIP1 MDM2-2 GADD45A RAN RASA1 AURKB GIT1 PPP2R5D CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling MAP3K1 MYC TRAF1 TRAF2 AKT1 TRAF6 MAP3K14 PIK3R1 RELA STAT5A PIK3CG MAPK14 PIK3R6 MAPK9 NFKB1 PIK3CB NFKBIA BCL2L1 PIK3CA JUN MAPK10 CD40 MAPK11 TNFAIP3 IL4 C4BPA FCAMR TRAF3 BIRC2 TDP2 CD40LG BIRC3 MAPK8 CBLB JAK3 MAP2K4 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network DDX54 SMARCA4 C3-1 SMARCB1 NR0B2 ESR2 SMARCE1 NCOA1 UBA3 NR0B1 NCOA2 NCOA3 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKA AURKC AURKB LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events STK11IP TP53 STRADA STRADB ETV4 MYC STK26 SIK3 SIK2 YWHAE GSK3B YWHAB YWHAQ SFN YWHAG YWHAH TSC2 YWHAZ MTOR CREB1 MARK2 MLST8 TSC1 PRKACA-1 CDC37 HSP90AA1 EZR RPTOR AKT1S1 BRSK1 BRSK2 CRTC2 SMARCD3 CAB39 SMAD4 PSEN2 STK11 MAPT MAP2 CTSD ESR1 SIK1;SIK1B MARK4 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EFNB2 EFNB1 EPHB2 EPHB1 EPHB4 EPHB3 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway MAP2K2;MAP2K1 MAPK3 NTF3 RPS6KA5 RUSC1 MAPKAPK2 MEF2C RAP1B EGR1 MAP2K5 PRKCD RIT1 TRPV1 MAPK14 RIT2 MAPK7 BRAF EHD4 ELK1 MAP3K2 CREB1 SRF RAP1A CDK5R1 NRAS HRAS MAP2K6 MAP2K3 FOS KRAS RPS6KA1 RAF1 MAPK1 CDK5 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway MAP3K1 TRAF1 TXN CHUK TRAF2 TNFRSF1A NRK MAP3K3 MADD MAP4K5 RFFL PRKCI TNIK NSMAF MAP4K3 MAP4K2 TAB2 TNFRSF1B TAB1 SQSTM1 TNF CYLD RELA CAV1 RACK1 STAT1 MAP4K4 SMPD2 NFKB1 PRKCZ IKBKB CASP8 MAP3K5 SMPD1 RIPK1 FADD IKBKG MAP3K7 MAP2K7 MAP2K3 TNFAIP3 ADAM17 BIRC2 TRADD BIRC3 BAG4 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks NR3C1 SP1 HNF4A AFP AKT1 ACADVL ALAS1 G6PC1 TAT SLC2A2 HMGCS1-1 TTR TFRC UCP2 NKX2-1 ACADM HADH PCK1 IGFBP1 CPT1A CREB1 KCNJ11 PKLR ABCC8 FOXF1 PDX1 APOA1 DLK1 HNF1A CPT1C CPT1B CEBPB GCK BDH1 ALB ALDOB F2 FOXA1 NF1 FOXA3 FOXA2 CEBPA CEBPD INS;INS-IGF2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events APC ARHGEF7 ARHGEF6 GSK3B PIK3R1 BRAF RASGRF1 MAPK9 PRKCZ PIK3CA JUN PAX6 MAP2K7 HES5 MAP2K6 SEPTIN2 TNK2 CDC42BPA ENAH PRKCE TIAM1 DLG1 CDC42 MAPK8 ATF2 VAV2 PAK4 MAPK1 RAC1 MAP2K4 MAPK3 MAP3K1 ARPC1B WASL PAK1 BCAR1 ARHGDIA ACTR2 YES1 PLD1 CBL IQGAP3 PAK2 ARPC4 ARPC5 BAIAP2 ARPC2 DIAPH3 ARPC3 MAPK14 ACTR3-1 MTOR MAP3K11 RPS6KB1 EPS8 SRC PARD6A CFL1 CDH1 HRAS CTNNA1 MAP2K3 EXOC7 LIMK2 LIMK1 MYL2 RAF1 CTNNB1 F2RL2 IQGAP1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events PAG1 GNAO1 GNAZ GNAI2 CSK CXCR4 RALB PIK3R1 CD3E RAP1B RACK1 BAD JAK2 PDPK1 STAT5A STAT1 STAT2 STAT3 DNM1 CD3G MAPKAP1 CD3D PIK3CB MLST8 PRKCZ HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RHOC RICTOR CD4 RHOB PIK3CA HLA-DRA CD247 RGS1 VPS4B VPS4A GRK6 UBQLN1 PTPRC CDC42 SSH1 PTK2B RAC1 GRK2 GNG2 ITCH AKT1 MMP9 RHOA PLCB3 PAK1 GNB1 BCAR1 PLCB1 FYN BLK YES1 ARRB2 HGS CXCL12 INPP5D FOXO1-1 GNA13 LYN STAT5B PIK3CG FGR PIK3R6 HCK MTOR PLCB2 ARR3 PTPN6 SRC CFL1 PXN VAV1 LCK LIMK1 PTPN11 PTK2 CRK GNAI3 GNAI1 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases SRF YWHAE YWHAB MAPKAPK3 YWHAQ MAPKAPK2 MAPK11 SFN YWHAG YWHAH ETV1 LSP1 TSC2 MAPK14 YWHAZ RAF1 CREB1 TH CDC25B HSPB1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling WNT1 MAPK3 APC PPARD MYC TLE5 GSK3B CCND1 CSNK1A1 TAB1 BTRC NOTCH1 ADAM10 FBXW11 RBPJ DTX1 DLL1 CSNK2A1;CSNK2A3 LRP6 HNF1A WIF1 TLE1 HDAC1 JUN FZD1 CTBP1 MAP3K7 FOS DVL1 AXIN1 PSENEN PSEN1 NKD1 NEDD4 DKK2 KREMEN2 APH1A CREBBP DKK1 CTNNB1 NCSTN APH1B MAPK1 PPP2R5D NLK VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms AEN SP1 CDKN2A CLCA2 YWHAQ GDF15 ADA TP53I3 ABL1 PRKCD MFGE8 ITGA3 IKBKB SERPINB5 ITGB4 MDM2-2 GADD45A FAS PERP OGG1 NOC2L FDXR DST DICER1 CDKN1A IGFBP3 TRAF4 SPATA18 EVPL SHH NQO1 WWP1 TFAP2C SSRP1 DHRS3 ITCH TP63 CHUK EP300 BAX HBP1 BTRC EGR2 PLK1 JAG1 PML CABLES1 PMAIP1 BBC3 SMARCD3 FLOT2 VDR S100A2 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway MAP2K2;MAP2K1 JAK1 MAPK3 MAP3K1 PTGES2 IRF9 DAPK1-1 EP300 AKT1 CAMK2A PIAS4 PIK3R1 CAMK2D CBL CASP1 SOCS1 RAP1B PTPN2 JAK2 PRKCD STAT1 MTOR MAP3K11 STAT3 CAMK2B PIK3CA CEBPB IRF1 IL1B RAP1A CALM3;CALM1 PTPN11 CAMK2G CRKL PIAS1 RAPGEF1 IFNGR1 IFNG CREBBP MAPK1 SMAD7 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway CD4 KDELR1 GOSR2 USO1 ASAP1 GBF1 CLTB AP2A1 ARFGAP1 GGA3 ARFIP2 AP2M1 PLD2 ARF1 COPA PIP5K1A CLTA CYTH2 RAC1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events IL1A UBE2N CHUK IRAK4 MAP3K3 TRAF6 PRKCI IL1R1 PIK3R1 TAB2 IRAK1 TAB1 SQSTM1 IL1RN ERC1 RELA CASP1 TICAM2 IL1R2 IRAK3 MYD88 TOLLIP UBE2V1 NFKB1 PRKCZ IKBKB PIK3CA IL1B JUN IKBKG MAP3K7 MAP2K6 IL1RAP MAPK8 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network TP53 IL5 SGK1-1 CSN2-1 MMP1 AFP GSK3B CXCL8 SFN RELA YWHAH TBP EGR1 STAT5A STAT1 SMARCC1 CSF2 MAPK9 NFKB1 TBX21 IL13 IL6 PRKACA-1 IRF1 JUN POU2F1 NFATC1 FOS MAPK10 MDM2-2 IL2 MAPK11 IL4 SELE IFNG KRT16;KRT14 POMC MAPK8 SPI1 CDKN1A MAPK1 CDK5 NR4A1 NR3C1 KRT5 MAPK3 EP300 AKT1 BAX NCOA1 NCOA2 FKBP4 SMARCA4 VIPR1 SUMO2 PRKACB-1 STAT5B PPP5C KMT5B POU1F1 MAPK14 SMARCC2 FKBP5 CREB1 SMARCD1 TSG101 NR1I3 CGA PCK2 PBX1 KRT17 FGG HDAC2 HDAC1 CDK5R1 HSP90AA1 GATA3 ICAM1 CREBBP PRL INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 ARHGEF7 EGF PIK3R1 SPRY2 CBL HGS ITSN1 RAB5A UBE2D1 TSG101 DNM1 SYNJ1 PIK3CB UBE2D3;UBE2D2 EPN1 SRC PIK3CA CHMP3 AMPH STAMBP NRAS HRAS SH3GL2 LRIG1 USP8 UBE2D3-1 PTK2 SH3KBP1 KRAS CDC42 GRB2 SOS1 RAF1 EPS15 SHC1-1 CBLB EGFR E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network CCNE2 SP1 CDKN2A XRCC1 CDK2 SMARCA2 RBL2 RB1 CDKN1B TP73 YY1 RBBP8 CCNA2-1 CBX5 PLAU CDKN1A HIC1 SERPINE1 CCND3 MYC WASF1-1 EP300 PRMT5 CASP7 SIRT1 HBP1 TFE3 APAF1 TRRAP KAT2B KAT2A E2F2 RBL1 TFDP1 TK1 TRIM28 E2F4-1 MCL1 CDC25A CDK1 UXT HDAC1 E2F1 MYBL2 DHFR2;DHFR CDC6 TFDP2 MCM3 SULT2A1-4 BRCA1 RRM2-1 CES3 RBBP4 CES2 TOPBP1 CES1 TYMS CES5A ORC1 E2F5 E2F6 E2F3 E2F7 RANBP1 RRM1 CDKN2C CEBPA CREBBP POLA1 RYBP CCNE1 ATM CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway NFKB1 NFKBIA IKBKB CHUK TNFRSF1A IKBKG TRAF6 XPO1 BCL10 TNF UBE2D3-1 CYLD MALT1 ERC1 TNFAIP3 PRKCA RELA BTRC RAN BIRC2 NOD2 RIPK2 ATM EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling EFNA5 EPHA5 FYN TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells CD8B;CD8B2 LCP2 PAG1 CSK HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TRAF6 TRPV6 CD3E LAT GRAP2 PLCG1 PDPK1 CD86 MAP3K8 CD80 PRF1 CD3G CD3D RASGRP2 IKBKB RASGRP1 CD28 ZAP70 IKBKG NRAS CD247 CARD11 PRKCB BCL10 PRKCE MALT1 KRAS PTPRC RASSF5 STIM1 ORAI1 CHUK AKT1 MAP3K14 FYN CBL PTPN6 RAP1A VAV1 HRAS LCK PRKCA B2M GRB2 SOS1 CD8A SHC1-1 PRKCQ REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase DKC1 POT1 TERF2 TERF2IP PIF1 SP1 PTGES3-1 SP3 TNKS WRN YWHAE ACD EGF ZNFX1 HNRNPC TERF1-1 CCND1 BLM CDKN1B WT1 ABL1 NFKB1 HUS1 IRF1 JUN RAD1 RAD9A FOS NR2F2 IL2 IFNG MAPK1 NCL-1 MAPK3 UBE3A SIN3B SIN3A MYC SMG5 AKT1 TGFB1 SAP30 MTOR RPS6KB1 MXD1 HDAC2 TERT HDAC1 E2F1 HSP90AA1 MAX MRE11 RBBP4 NBN SMAD2;SMAD3 SAP18 RBBP7 XRCC6 XRCC5 IFNAR2 RAD50 PINX1 SMG6 ESR1 PARP2 EGFR TINF2 ATM REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein SKP2 ELF1 CDK4 CBX4 CDKN2A CDK2 CDK6 SUV39H1 AATF CCND1 BRD2 RB1 PAX3 RBP2 CDKN1B DNMT1 CKM TBP PPP2R3B ATF7;ATF7-NPFF ABL1 TAF1 MET CSF2 MAPK9 CCNA2-1 JUN SFTPD TGFB2 MDM2-2 MAPK11 ATF2 SPI1 CDKN1A PPP2CB;PPP2CA CCND3 EP300 MITF SIRT1 MEF2C PPARG HDAC3 SMARCA4 RUNX2 MAPK14 CCND2 E2F2 UBTF TFDP1 MYOD1 E2F4-1 CEBPB HDAC1 E2F1 CTBP1 RBBP4 GSC SMARCB1 E2F3 RAF1 CEBPA CREBBP CEBPD CCNE1 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling MAPK3 MAP3K1 CTDSP1 PIAS4 CTDSP2 UBE2I CALM3;CALM1 SMAD2;SMAD3 TGFBRAP1 CTDSPL NUP153 PPM1A KPNB1 SMAD4 KPNA2 NUP214 MAPK1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network EDN1 SP1 ID2-1 CITED2 EPO SLC2A1 CXCR4 PGK1 VEGFA COPS5 LEP EGLN1 EGLN3 BHLHE40 BHLHE41 NOS2 RORA ABCG2 ADM IGFBP1 HIF1A HK2 FURIN HK1 NDRG1 CA9 TF PGM1 PKM PLIN2 ALDOA PFKFB3 ABCB1 FECH NT5E GCK ARNT CP JUN PFKL ITGB2 FOS BNIP3 NPM1-2 ETS1 SERPINE1 HNF4A EP300 AKT1 NCOA1 NCOA2 CXCL12 TFF3-1 GATA2 TFRC ENO1 HDAC7 CREB1 ENG MCL1 TERT SMAD2;SMAD3 LDHA HMOX1 CREBBP SMAD4 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway VLDLR AKT1 GSK3B FYN PIK3R1 CBL MAP1B NCK2 ITGA3 MAP3K11 LRP8 RELN DAB1 PIK3CA RAP1A CDK5R1 GRIN2A PAFAH1B1 MAPK8IP1 ITGB1 MAP2K7 ARHGEF2 GRIN2B CRKL RAPGEF1 LRPAP1 MAPK8 MAPT CDK5 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway MAPK3 PIK3CB MAP3K1 IKBKB CASP8 PIK3CA CASP10 CHUK TRAF2 SMPD1 RIPK1 FADD IKBKG TNFSF10 DAP3 PIK3R1 CFLAR TRADD MAPK8 MAPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MAP2K4 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling MAPK9 GNG2 MAPK8 GNAL MAPK14 GNB1 CRH MAPK11 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP JAK1 ATR EIF2AK2 HGF PTPN1 EGF INSR VEGFA PIK3R1 STAT6 PTPN2 STAT5B STAT5A STAT1 STAT3 MET RAB4A PIK3CB SRC PIK3CA ITGB1 GAB1 LMAN1 KDR PDGFRB PIAS1 ITGA1 CSF1R GRB2 CREBBP SOS1 KPNB1 KPNA2 PDGFB CSF1 SHC1-1 EGFR JAK3 EIF2A INS;INS-IGF2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling GSK3B CTDSP1 CTDSP2 TAB2 BMPR2 TAB1 SMAD1 CTDSPL SMAD9 PPM1A SMAD5 BMP4 XIAP SMURF1 PPP1CA MAP3K7 CHRD ZFYVE16 CHRDL1 HJV PPP1R15A SOSTDC1 CER1 AHSG FST SMURF2 NOG RGMB SMAD6 BAMBI BMP6 RGMA SMAD4 GREM1 NUP214 BMP2 MAPK1 BMPR1A BMP7 SMAD7 SKI PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events GNG2 RHOA GNB1 F2 ROCK1 ROCK2 GNA13 GNA14 MYL2 GNA15 GNA11 GNAQ F2RL2 F2RL3 PLCB2 FSH%NETPATH%FSH FSH MAP2K2;MAP2K1 GRK4 AKT2 FSHB FSHR GRK6 CGA APPL1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog ARRB2 GLI1 GLI2 MED12 PRKACA-1 CCNB1 GRK2 STK36 BOC SAP18 MED1 PTCH1 PTCH2 DYRK1A KIF7 MED6 KIF27 MED23 CDK8 CTNNB1 GAS1 YWHAE DHH HHIP IHH ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor AR CREB1 HDAC1 HSPB1 AKT1 PIK3R1 PTK2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor HNF4A NCOA1 MAP4K1 PDPK1 FOXO1-1 FOS PJA1 TGFBR2 NME1 TGFBR3 RBL2 PPM1A KAT2B ZEB2 ZEB1 TFDP1 TFDP2 PIK3CA CRK CD44 ENG PPP1R15A FZR1 PARD6A STAMBPL1 YAP1-1 CTNNA1 SIK1;SIK1B MAPK1 CTNNA2 SAMD3 MAPK3 NFYB NFYC UBE2D3;UBE2D2 AP2B1 PML SKI FKBP1A EIF3I FOSB BCAR1 TRIM33 ARRB2 AR HDAC1 AKT1 PIK3R1 PTK2 RB1 ATF2 SPARC ZFYVE9 UBE2D1 ETS1 STK11 HOXA9 CDC23 CCND1 FNTA MYC SNIP1 SOX9 BTRC JUNB VPS39 SKP1 PDK1 NUP214 MAP2K3 MEF2A DAXX MEF2C ANAPC7 RUNX3 CDC25A RUNX2 RUNX1 RBX1 EID2 ZFYVE16 PRKAR1B CCNE1 EWSR1 ANAPC4 ANAPC5 TP53 PPP2R2A;PPP2R2D ANAPC1 ATF3 KPNB1 ANAPC2 E2F4-1 SDC2 PXN CUL1 PIK3R2 FOXO4 FOXO3 ANAPC10 SNX4 CCNB2 SNX1 SNX2 PRKAR2A SPTBN1 SNX6 MAP2K6 TRAP1 WWTR1 HSPA8 TGFB2 JUN SMAD4 JUND TGFB1 UBE2I SMURF1 TGFB3 VDR STK11IP CAV1 IRF2BP1 NUP153 SMAD6 ESR1 DAB2 SNW1 CDK6 COPS5 SP1 CDK4 CDC16 NFYA-1 DYNLRB2 DYNLRB1 TAB1 DCP1A TP73 GSK3B CDKN1A CITED1 BRCA1 CTCF UBE2D3-1 ING2 XPO1 XPO4 SUMO1 TCR%NETPATH%TCR TCR SHC1-1 MAP2K2;MAP2K1 DYRK1A CTNNB1 CREB1 AKT1 PIK3R1 PTK2 ATF2 PXN PIK3R2 GSK3B CRK MAPK1 MAPK3 ITSN2 CYFIP1 TFRC WIPF1 CBLB ENO2 CRKL GOLGA5 UBASH3B DPYSL2 TRIM25 HOMER3 PRKCD CD2AP PARD3 PRKD2 PRKD1 EPHA3 SKAP1 TXK PTTG1IP BCL10 LY9 LDHB LDHA INPP5D PLCG2 SLAMF6 PLCG1 ICOS PAG1 LYN VASP EGR1 CREBBP FYB1 NFATC2 LNPEP NFATC1 CGN EPRS1 CD28 UNC119 GRB2 GRAP CALM1 ADA ITK MTMR10 CLTC GDI2 CD3G PTPRH SHB CD3E CD3D IKBKB PPP3CB TUBA1A CTLA4 JAK3 VAV3 DUSP3 DBNL ANXA2 SYK RIPK2 FCRL3 NFAM1 PGAM1 GAB2 ZDHHC17 VAV1 VAV2 ENAH BDH1 RAPGEF1 ARHGEF2 HNRNPH3 ARHGEF7 ARHGEF6 AHCY WAS NEDD9 RELA PAK1 FLNB CCT8 MPZL1 DDX3X-1 GIT2 STAT1 ERBIN ELP3 DEF6 ACTR10 CD86 CD84 CD82 CD80 DGKA SLA ARHGAP35 SIT1 GRAP2 ARHGDIB MAP3K8 G6PD KIRREL1 ANXA11 SKAP2-2 DYRK1B PRPF4B LAX1 TUBA4A DOK1 ACLY DOK2 HGS ELMO1 ADAM9 PKP4 RAF1 STAM2 CARD11 KHDRBS1 TSG101 STK39 ITPR1 RASGRP2 STK4 RASGRP1 SDCBP RAP1A CASKIN2 ABL1 LPXN BMF ACBD6 NFKB1 NFKBIA DIAPH1 NCL-1 FER PTPRC PTPRA TUBB4A;TUBB;TUBB8B;TUBB8 OGN CDK1 PI4KA LAT NFKBIB HSP90AB1 DDX49 WDR1 PTPN22 CABIN1 PIK3C2B PSTPIP1 YWHAQ SNRNP70 ZNF404 ACP1 PGM1 NCK1 CHUK SH2D3C MSL2 YWHAZ DNM2 ACTA1 ZAP70 PKM LCK RASA1 PECAM1 C9orf78 LCP2 EVL DOCK2 SOS1 SOS2 R3HCC1L CEBPB SRC ATP1A3 ATP1A1 CBL HDAC7 DNAJB1 MUC1 MAPK8 MAPK7 SH3BP2 PTK2B SH2B3 TRAT1 TXNRD1 PTPN11 PTPN12 MAPK14 CD2 MAPK11 CD4 EIF3M TEC RPS6KB1 CD5 CD7 PTPN6 PIK3AP1 RAN PTPN3 LEPTIN%NETPATH%LEPTIN Leptin SHC1-1 CRP NCOA1 PRKAA1 GSK3A PRKAA2 ITGB5 PLCG2 IRS1 STAT1 IRS4 PLCG1 SLC2A4 ACACB EGFR IGF1R RPS6KA2 CFL2 ERBB2 EIF4EBP1 FYN CHUK EIF4E SOCS7 JAK1 SH2B1 NOS3 PRKCE GRB2 RPS6 LIMK1 AKT1 CDK5 GNAQ PTK2 LEP MAPK1 PDE3A SRC IKBKB JAK3 KHDRBS1 ESR1 MAPK8 GSK3B RUNX2 NFKBIA RPS6KB1 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor STAT1 EIF4EBP1 FYN PIK3CA CRK RPS6 AKT1 PIK3R1 MAPK1 PTPRU ATF2 SH3KBP1 SPRED2 GYS1 SPRED1 RPS6KA1 EP300 JAK2 HRAS RAF1 PRKCB MATK PRKCA MITF FGR HCK KIT TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A WIPF1 EZR CBLB GRB7 CSF2RB CRKL SOCS1 ABL1 SOCS6 SOCS4 SOCS5 STAT5A STAT5B YES1 RDX MSN MTOR EPOR MAPK12 KITLG FES CDK2 IL7R MAD2L1 INPP5D GRAP RASA1 JUN CLTC SOS1 SRC JAK3 MAPK8 PTPN11 MAPK14 GSK3B TEC RPS6KB1 WAS RELA BCR%NETPATH%BCR BCR SHC1-1 MAP4K1 GSK3A PDPK1 FOS EIF4EBP1 FYN CRK RPS6 MAPK1 RPS6KA1 PRKCB FOSB BCAR1 HCK CRKL PRKCD PRKD1 CDK2 BCL10 SLA2 ELK1 TCL1A PIP4K2A PIP4K2B PIP4K2C PLCG1 GTF2I MAPKAPK2 BTK LYN IFITM3;IFITM2;IFITM1 PRKCQ CCL3L1;CCL3L3;CCL3;CCL18 ITPR2 RASGRP3 NFATC2 CD79B CD79A BTLA CHST15 STAP1 PIP5K1A PIP5K1B GRB2 PIP5K1C NFATC3 CDK7 HNRNPK ITK BCL6 CD22 PIK3CG CASP9 CASP7 BLNK LAT2 BANK1 IKBKB HCLS1 MALT1 CYCS-1 CCL4L2;CCL4L1;CCL4 SH2B2 PTPN18 CD72 PLEKHA1 PLEKHA2 STAT3 BAX VAV1 RAPGEF1 NEDD9 RELA STAT1 CTNNB1 CREB1 AKT1 PTK2 RB1 ATF2 DOK1 CARD11 JUNB ITPR1 PIK3R2 FOXO3 NCK1 CHUK ZAP70 LCK RASA1 JUN SOS1 SOS2 SH3BP2 MAPK14 GSK3B TEC RPS6KB1 PTPN6 TNFALPHA%NETPATH%TNFALPHA TNFalpha IRS1 EGFR EP300 PRKCA STAT5A GTF2I MAPKAPK2 CASP7 BAX RPL4 RPL30 SMARCB1 RPL8 RPL6 DCAF7 PSMD6 TBK1 PSMD7 AKT2 RPS6KA5 PSMD2 PSMD3 DPF2 PSMD1 RPS11 YWHAE RPS13 SMARCC1 SMARCC2 PSMC2-1 CDC34 CDC37 KCNQ1 TXNIP TRIB3 TXN IQGAP2 GLG1 FADD CRADD SMARCA4 REL FAF1 SMPD3 NKIRAS1 CASP10 NKIRAS2 RFK RACK1 IKBKG IKBKE RIPK3 CREB1 ACTL6A HDAC1 GAB1 HSPB1 AKT1 COMMD1 TAX1BP1 PTK2 CSNK2A1;CSNK2A3 RB1 AKAP8 XIAP TANK RELB PSMB5 RXRA FLNA BID MAP3K2 MAP3K3 ELP1 DIABLO-1 LRPPRC KTN1 BTRC ITCH JUNB PSMC3 PSMC1 SKP1 PKN1 PDK1 CCNT1 ZFAND5 TNF FBL PAPOLA KPNA6 TNFRSF8 KPNA2 KPNA3 MAP3K5 UNC5CL FBXW11 FBXW7 USP2 CYBA TRPC4AP TXLNA FANCD2 NUPR1 FKBP5 NSMAF COPB2 PSMD12 PSMD13 TNFRSF11A RASAL2 BAG4 BRINP1 CUL1 NLRP4 G3BP2 MAP2K5 MARK2 ZBTB17 MCC CDK9 COPS3 BCL3 ALPL TAB3 TAB2 MAP2K6 NFKBIE TRAP1 MAP3K11 BCL2L1 RNF11 MCM7 JUN YWHAB PPP6C BCL7A PPP1R13L UBE2I CASP3 NFKBIZ CASP2 YWHAG YWHAH CAV1 HSP90AA1 PPP1R12A PEG3 TNFRSF1B TRAF7 RASA3 TRAF4 POLR1A POLR1B TRAF6 POLR1C TRAF5 POLR1D POLR1E MCM5 TAB1 PFDN2 BIRC2 BIRC3 HDAC2 USP11 MTIF2 NR2C2 HDAC6 UBE2D3-1 MAPK9 ERBB3 TIFA ROMO1 SUMO1 POLR2H RFFL POLR2L SMARCE1 SPAG9 FOXO1-1 RNF25 CFLAR GLB1 TNIP2 PRC1 PDCD2 TBKBP1 TRIM32 MAPK1 MAPK3 UBE2D3;UBE2D2 PML CREBBP GRB2 PAK1 DDX3X-1 STAT1 MAP3K8 DOK1 NFKB1 NFKBIA HSP90AB1 YWHAQ YWHAZ SOS1 SOS2 SRC MAPK8 PTPN11 MAPK14 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin PAK1 SHC1-1 FOS IRS1 ERBIN EGFR RTKN ITGB4 PIK3CD ERBB2 LAMC2 EIF4EBP1 IRS2 FYN LAMC1 PIK3CA EIF4E PIK3CB MYLK3 RAC1 EPHB2 AR DSP DST GAB1 RPSA AKT1 RHOA ITGA6 PIK3R1 MET PTK2 PLEC MAPK1 COL17A1 LAMA5 CD151 MAPK3 LAMA2 LAMA3 PIK3R3 MST1R NTN1 SMAD2;SMAD3 CLCA1 SFN PRKCA LAMB3 BAD LAMB2 LAMB1 EIF6 VIM ABL1 PRKCD YES1 MTOR YWHAQ PIK3R2 YWHAZ GRB2 YWHAB JUN PIK3CG CASP3 YWHAH SRC PTPN11 MAPK14 TP73 YWHAE WNT%NETPATH%WNT Wnt ARRB2 PRKACA-1 RAC1 AKT1 RHOA CCND1 PRKCB PRKCA PPP2CB;PPP2CA CHD7 DIXDC1 SOX1 CDH1 MAP3K7 PRKCG WNT5A AXIN1 PRKCD KREMEN1 YES1 DKK1 PAX2 SFRP1 SFRP2 DAAM1 ARHGEF4 ROR1 PI4K2A LRP1 CTBP1 LEF1 LRP5 NLK MESD FRZB GPC3 DVL3 WNT1 WNT2 WNT3 FZD1 MARK2 SMAD1 TCF7L2 JUP NFATC2 FZD5 SETDB1 CSNK1A1 FZD4 FZD7 FZD6 PIP5K1B FZD9 PPP1CA BCL9 PIN1 TCF4 YWHAB JUN MAPK8 CDK6 IL6%NETPATH%IL6 IL6 SHC1-1 NCOA1 FOXO1-1 FOS STAT1 ERBB2 EIF4EBP1 FYN EIF4E JAK1 RAC1 AR HDAC1 HSPB1 GAB1 AKT1 PIK3R1 RB1 MAPK1 MAPK3 EP300 BAD FGR HCK DAXX MAP3K7 STAT5A STAT5B NFKB1 PRKCD NLK PLCG1 BTK LYN PIK3R2 FOXO4 FOXO3 CREBBP CDK9 MAP2K6 GRB2 CD40 JUN SGK1-1 IL6R MAP3K4 EIF2A PIAS3 MAP2K4 TYK2 HNRNPA1-1 HSP90AA1 IL6ST SOCS3 CBL BMX IL6 MAPK8 STAT3 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 GSK3B RPS6KB1 ERBB3 TSH%NETPATH%TSH TSH IKBKB ATP1A1 RAF1 HSPA5 CALR-1 GNAI3 SCRIB IGF1R TSHR GNAI1 GNAS-1 GNAI2 MAP2K3 GNAO1 GNA13 GNA11 CANX GNA12 CREB1 MAP2K6 GNAQ LEP MAPK3 EGFR1%NETPATH%EGFR1 EGFR1 EPHB1 EPHB4 TNS2 TNS1 EPHB3 EPHA4 ACTN1 KRT8 KRT7 KRT5 ACTN4 GAREM1 TAGLN2 PFN1 TLN1 RIN1 EPHA1 EPHA2 SDC4 ASAP3-1 SDC3 MYL12B RACGAP1 RALGDS SNX5 INSR STAM SMU1 SPART SDC1 CC2D1A PTPRR HIP1 AP2A1 PTPRK WASL LIMD1 PTPRF OTUD6B GIT1 NCOA3 RALBP1-1 MINK1 IL17RD CTTN ALDOA ARHGEF5 CSTB PRKX SH3BGRL PDZD11 CDV3-1 CD59 MAP4K5 UBB;UBC CAVIN1 CAVIN2 PLEKHA5 HUWE1 PLEKHA6 ATP5F1C CALM3;CALM1 KRT18 KRT17 AXL NEDD4 EPPK1 ESYT1 TJP2 SH3GL3 INPPL1 PEBP1 ARHGAP42 PDGFRB APLP2 EEF1A1 ADAM17 EEF1A2 ELMO2 VCL DDX6 DAPP1 PLD1 LPP PLD2 EFNB2 CALD1 RIPK1 CAV2 CRIM1 ARHGAP32 DLG3 ACTR3-1 DYRK3 DOCK4 USP31 FLOT1 KLF11 LSR ARAP1 EPN1 EPN2 EPN3 ACTA2 ELF3 MYH9 DOCK1 GRB14-1 RALB RGS16 MVP ASAP1 PDLIM1 MARVELD2 REPS2 MTA2 MAP2K2;MAP2K1 PDLIM4 SNCA EGF SPRY4 HSPE1 TNIP1 SPRY3 APPL1 SPRY2 KRAS SPRY1 ZPR1 DYRK1A CREB1 HDAC1 PIK3R1 PTK2 STK11 MYC MAP2K3 ZFYVE16 TP53 PIK3R2 FOXO4 JUN JUND CAV1 DAB2 SP1 GSK3B PDPK1 FOXO1-1 FOS PIK3CA CRK MAPK1 AP2B1 ITSN2 TFRC CBLB CRKL UBASH3B PRKCD PARD3 PRKD1 PTTG1IP LDHA PLCG2 PLCG1 LYN VASP CLTC SHB PGAM1 VAV1 VAV2 ARHGEF7 NEDD9 RELA PAK1 FLNB MPZL1 DDX3X-1 GIT2 ERBIN ARHGAP35 KIRREL1 DYRK1B PRPF4B DOK1 DOK2 ADAM9 PKP4 RAF1 KHDRBS1 SDCBP CASKIN2 ABL1 NFKB1 PTPRA CDK1 PIK3C2B ACP1 NCK1 YWHAZ PKM LCK CEBPB ATP1A1 MAPK8 MAPK7 PTK2B PTPN12 MAPK14 RPS6KB1 PTPN6 PRKAA1 GSK3A PRKAA2 EGFR RPS6KA2 ERBB2 EIF4EBP1 FYN JAK1 SH2B1 NOS3 CDK5 SH3KBP1 RPS6KA1 JAK2 HRAS PRKCA KIT GRB7 SOCS1 STAT5A STAT5B MTOR CDK2 ELK1 PIK3CG CASP9 PTPN18 RPL30 RPS6KA5 GAB1 MAP3K3 ITCH YWHAB MAPK9 ERBB3 ITGB4 PIK3CD IRS2 PIK3CB RAC1 EPHB2 DSP RHOA MET PLEC COL17A1 PIK3R3 SMAD2;SMAD3 BAD VIM CDH1 PRKCG ARHGEF4 CTBP1 JUP MAP3K4 PIAS3 TYK2 HNRNPA1-1 SOCS3 SCRIB USP6NL ATF1 ARAF HNRNPR ENO1 ELK4 GJA1 TFG MPRIP ANKS1A TGIF1-1 PRKCI FRS2 FRS3 KIAA1217 PRKAR1A KRT6B;KRT6C;KRT6A RBCK1 SERPINB3;SERPINB4-1 IQGAP1 SLC5A5 ANTXR1-1 MYO6 S100A14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 S100A11 S100A10 AFAP1L2 RBM3-2 BRAF CYLD TOLLIP TRIP6 PYGB RPLP0 CLTA ARHGAP5 ENSA PLEKHN1 APPL2 ANXA1 ANXA4 EPS15L1 PLSCR1 GPRC5A TKT PHLPP1 AHNAK RPS27L HTT SNX33 AP2S1 STX4 RICTOR RPS2 LDLR GSN MCF2 STAT2 HIPK3 DCBLD2 HIPK2 PKN2 FRK CTNND1 ARF4-1 C11orf52 LAPTM4A CYSRT1 CDH3 CDH2 CFL1 TOM1 GRB10 MAGI1 DYRK4-1 TOM1L1 TOM1L2 HAT1 PKP2 STAMBP PKP3 PHPT1 PHLDB2 SIRPA;SIRPB1;SIRPG STIP1 ATXN2 ITLN2;ITLN1-2 HNRNPDL ABL2 MAP2K7 SLC38A2 TNK2 PTPRE ACTB-1 ALB BCL2 RAB5A MAP3K14 EIF4G1 ITGB1 BCAR3 CALCOCO2 PTEN PTPN23 NCK2 SFPQ-1 CCDC50 ACTR2 PDCD6IP ITGA3 DSG2 SLC25A6 CEBPA WBP2 SRI CDC42 SLITRK6 CSK RBBP7 CTNNAL1 PTPN1 PPP1R14B BAIAP2 NECTIN1 ERRFI1 APP AHCYL1 PITPNA ZDHHC5 CBLC RPS6KA3 BAIAP2L1 SNRPD2 TRIM29 TNS4 RPS10 TNS3 SLC12A7 ID%NETPATH%ID ID FHL2 PAX5 ELK3 ELK1 RBL1 PSMD4 ATF3 SMAD2;SMAD3 ID3 RAF1 HES1 MYF5 RBL2 TCF7L2 MAP2K2;MAP2K1 ELK4 RB1 MAPK1 SMURF2 CDK2 MAPK3 IL9%NETPATH%IL9 IL9 TYK2 STAT5A STAT5B KAT5 STAT6 IL9R MAPK1 MAPK3 IL3%NETPATH%IL3 IL3 SHC1-1 GSK3A PRKACA-1 INPP5D FOXO1-1 LYN SLC2A1 PIK3R2 GATA2 SOCS2 PIK3CD BCL2L11 KCNIP3 IL3 RARA CRK RACK1 YWHAZ CREB1 GAB1 BCL2L1 PIK3R1 YWHAB PTK2 MAPK1 DOK1 RXRA SOCS3 HRAS PRKCB PRKCA BAD PPP2CB;PPP2CA CSF2RB CRKL GAB2 MAP2K2;MAP2K1 ATF1 GSK3B NFKB1 PTPRC PTPN6 FES IL5%NETPATH%IL5 IL5 SHC1-1 GSK3A ELK1 STAT1 LYN FOXO3 IL5RA ALOX5 RACK1 JAK1 YWHAZ CTNNB1 SOX4 DNM2 PLA2G4A UNC119 IL5 GRB2 IL2RB JUN ATF2 PIK3CG SOS1 RPS6KA1 HCLS1 HRAS RAF1 CBL HCK SYK STAT3 PTK2B BAX SDCBP CRKL SOCS1 PTPN11 MAPK14 MAP2K2;MAP2K1 STAT5A GSK3B STAT5B NFKB1 PRKCD NFKBIA RAPGEF1 IL4%NETPATH%IL4 IL4 SHC1-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PIK3CD IRS2 PIK3CA JAK1 SPI1 AKT1 IL13RA1 IL13 STAM SND1 PTK2 CXCR4 MAPK1 ATF2 IL2RG GRK3 MAPK3 IL4 ETS1 EP300 JAK2 NCOA3 BAD SOCS1 NFKB1 PRKCD NFKBIA ELK1 INPP5D PLCG2 CREBBP CHUK RASA1 CD40 TYK2 CEBPB IKBKB CEBPA CBL MAPK8 SYK STAT3 PTPN11 MAPK14 MAPK11 RPS6KB1 PTPN6 IL-7%NETPATH%IL-7 IL-7 IL7 IL7R SHC1-1 GSK3A FOXO1-1 STAT1 IRS1 JAK3 BAD STAT3 FOXO3 CBLB IRS2 FYN MAP2K2;MAP2K1 STAT5A STAT5B GSK3B AKT1 PIK3R1 STAM MAPK1 IL2RG MAPK3 NOTCH%NETPATH%NOTCH Notch HES1 KAT2B AKT1 PIK3R1 MAPK1 MAPK3 MAML2 MAML1 FHL1 EP300 RBPJ JAK2 LFNG SMAD2;SMAD3 YY1 SIN3A CCN3 CIR1 SKP2 PSENEN HES6 SKP1 RING1 SAP30 NCOR2 NCOR1 MFNG MAML3 NOTCH2 NOTCH4 PSEN2 DTX1 NFKB1 FURIN DLL3 RBX1 APH1A FBXW7 DLL4 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 NCSTN APH1B SPEN JAG2 LEF1 CUL1 SMAD1 SRC SNW1 STAT3 APP GSK3B HDAC2 RELA IL2%NETPATH%IL2 IL2 SHC1-1 IRS1 PIK3CD EIF4EBP1 IRS2 FYN PIK3CA EIF4E PIK3CB CRK JAK1 CREB1 RPS6 IL2RB AKT1 PIK3R1 STAM MAPK1 ATF2 IL2RG MAPK3 ETS1 PIK3R3 RAF1 STAM2 CRKL STAT5A STAT5B NFKB1 MTOR CCNE1 CDK2 YBX1 NR3C1 ETS2 ELK1 IL15 PLCB1 PRKCZ TERT MKNK1 STAT4 NMI LYN IL2 PIK3R2 VIL1 IL2RA FOXO3 ITM2B EIF3B BCL2 GRB2 LCK JUN SGK1-1 PIK3CG SOS1 SHB HSP90AA1 SOCS3 CBL JAK3 MAPK8 PTK2B GAB2 PTPN11 VAV1 MAPK14 MAP2K2;MAP2K1 PTPN6 RELA TSLP%NETPATH%TSLP TSLP STAT1 STAT4 STAT6 MAPK8 STAT3 NFKB2 EIF4E MAPK14 MAP2K2;MAP2K1 STAT5A STAT5B NFKB1 NFKBIA AKT1 MAPK9 MAPK1 RELA RELB MAPK3 RANKL%NETPATH%RANKL RANKL MITF MAPK8 REL TRAF6 NFKB2 TRAF5 CHUK TRAF2 TNFRSF11B TREM2 TRAF1 MAPK14 TAB1 MAP3K7 TRAF3 TNFSF11 TAB2 NFKB1 ATP6V1E1 SQSTM1 SPI1 PTK2 IL1%NETPATH%IL1 IL1 PIK3R2 REL CHUK TOLLIP TAB3 PLA2G4A TAB2 MAP2K6 MAP3K14 IL1RN PELI2 AKT1 PIK3R1 IRAK1 IRAK2 JUN RB1 PPP6C MAPK1 FBXW5 ATF2 IL1R1 IL1R2 DOK1 MAPK3 IRAK3 IRAK4 SOD1 IL1A IKBKB IL1B MAP3K2 PELI1 UBE2N ELP1 UBE2V1 MYD88 MAPK8 TRAF6 MAP2K3 MAPK14 TAB1 NFKB1 NFKBIA MAPK9 RELA ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis ILVBL BCAT1 BCAT2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway RPIA GPI HKDC1 TALDO1 PGD TKT HK2 HK1 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis MTHFD1L MTHFD2 MTR-1 TYMS DHFR2;DHFR FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism ALDOC ALDOB HKDC1 ALDOA KHK HK2 HK1 GALE GALT P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway MAP3K4 MAP2K6 MAP2K4 MEF2C IL1R1 MAPK14 MEF2B;BORCS8-MEF2B MAPK12 MAPK13 MAPK11 MAPKAPK3 TRAF6 MAPKAPK2 MAP3K10 TAB2 TAB1 ATF1 SRF HSPB1 ELK1 RPS6KA4 EEF2K RPS6KA5 MKNK1 MKNK2 EIF4E MEF2D MAP3K7 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA HSPB1 MAPK14 MAPKAPK3 MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR RAC3 AKT1 RAC1 HRAS PRKCG PRKCI PRKCH PRKCB SPHK2 SPHK1 PRKCE PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway MAPK3 NOS3 BRAF IL21 GSK3B CDKN1A CXCL8 SPI1 CDKN1B IRS1 IL5RA IRS2 SLA2 ELK3 IKBKB ELK4 RPS6KA3 SPIC RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 AKT3 IL13RA2 JAK3 IL6R IL13RA1 IL10 IL11 IL4R CHUK IL15 PDPK1 IL11RA IL13 IL18 FOS IL1A IL23A IL3RA SOS1 IL6ST SOS2 IL20RA FOXO3 MAPK7 CXCR1 CXCR2 STAT4 SRF STAT6 MAPK6 ELK1 IL12RB1 IL12RB2 STAT5A STAT5B MKNK1 STAT1 MKNK2 IL10RB STAT2 IL10RA STAT3 MAPK15 MTOR IL2 IL4 IL6 IL5 IL7 IL2RA IL9 IL2RB SHC1-1 MAPKAPK2 ARAF PIK3CB AKT1 PIK3CA RAF1 NRAS MAPK1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis FLAD1 RFK HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis EPRS1 UROD RSAD1 HMBS CPOX PPOX EARS2 COX10 ALAD QARS1 FECH NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CHRNA3 KCNK9 CHRNA5 EPB41 CHRNA4 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G PRKACA-1 GNG2 EPB41L1 EPB41L2 FLNA DRD2 DRD4 SLC18A2 CHRNB2 CHRNB4 CHRNB3 PPP1CA PPP1R1B GNB1 KCNK3 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system PER2 PER1 CRY2 CRY1 TPTEP2-CSNK1E;CSNK1E CSNK1D CLOCK ARNTL CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis MVD PDSS1 HMGCR LSS FDFT1 HMGCS1-1 FDPS SQLE MVK GGPS1 IDI2 PMVK IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway GRIA1 GRIA2 SNAP25 STX19 GRIK5 SLC1A1 SNAP23 GRIK3 SLC1A2 GRIK4 SLC1A3 GRIK1 GRIK2 SLC1A6 SLC1A7 STX11 GRM3 GRM2 GRIN2A SLC17A6 SLC17A8 SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 GRIN3A VAMP1 SHANK3 VAMP2 SHANK1 VAMP3 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PSAT1 PNPO CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle CCND3 CCND2 CCNE1 RPA3 CINP P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 MAPK14 MAPK12 CDKN1A MAPK13 MAPK11 PIK3CD PIK3CB PIK3C2A AKT2 PIK3CG PIK3C2B AKT3 AKT1 HRAS PDPK1 PIK3CA CCNE1 PIK3C3 RB1 PPP2CB;PPP2CA PTEN PIK3C2G PIK3R5 TP63 SIAH1 PIK3R3 TPTE;TPTE2 PIK3R2 RBL1 PIK3R1 CDK2 CCNG1 CTNNB1 NRAS ATM KRAS TP53 TP73 ATR THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THNSL1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation ABAT HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway PLCG1 ITPR1 ITPR2 ITPR3 GNA14 GNG10 HRH1 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PRKCZ PLCG2 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway GRIN1 PRKAR1A GRINA ITPR1 PRKACA-1 GRIN3A PRKCB GRIK5 GNA11 GRIK1 PLCB4 GNAQ GRIN2A HOMER1 PRKX GRM1 GRIN2C PRKACB-1 GRIN2B GRM5 GRIN2D PRKAR1B OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response MAP2K6 MAP2K3 MAP2K4 JUN MEF2C MAX TXN MAPK14 MAPK9 MAPK12 MAPK8 MAPK13 DDIT3 PLA2G4A MAPK11 BCL2 ELK1 MYC EEF2K STAT1 MKNK1 MKNK2 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 KCNK9 PRKX PRKACB-1 ADCY2 GNAI1 PRKACA-1 GNG2 GNAI3 ADCY7 GNAI2 PRKAR2B PRKAR2A HTR1E GNB1 HTR1F KCNK3 HTR1D HTR1A HTR1B GNAO1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway PLCG1 GNA14 GNG10 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ OXTR PRKCZ PLCG2 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway GNG2 GNG10 GNG5 GNG4 ADCY7 GNG8 GNB1 GNB2 GNB4 GNB3 GNB5 HTR4 GNAL ADCY2 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling GABBR2 GABBR1 ADCY9 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 PRKACB-1 ADCY2 PRKAR1B GNAI1 PRKAR1A CACNA1G PRKACA-1 GNAI3 ADCY7 PRKAR2B PRKAR2A GNB1 GNAO1 ADCY4 CACNA1B CACNA1A ADCY1 ADCY8 ADCY6 ADCY5 KCNJ3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway UBA7 UBE2B UBE2D4 UBA6 UBE2C UBE2E3 UBE2E1 UBE2D1 UBE2E2 UBE2G1 UBE2L6 UBE2G2 UBE2D3;UBE2D2 UBE2D3-1 UBE2S UBE2T UBE2N UBE2V2 UBA3 UBA2 UBA1 SAE1 ATG7 UBE2K ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway GSK3B APP ACTC1;ACTG2 WNT2B FZD10 RBPJ ACTG1 CDH3 KAT5 CDH1 TRIM2 TRIM3 TRPC7 PSENEN ACTR2 TRPC5 TRPC6 WNT5B TRPC4 TRPC1 WNT5A WNT9B WNT9A WNT16 ERN1 ACTA2 BACE1 ACTA1 BACE2 ACTBL2 CD44 RBPJL NOTCH2 CTNNB1 NOTCH3 NOTCH1 LRP1 NOTCH4 LEF1 LRP5 WNT8A PSEN2 WNT8B LRP4 LRP3 PSEN1 LRP2 FSTL1 LRP6 WNT6 NCSTN WNT11 APH1B ERBB4 DVL1 DVL2 DVL3 APBB2 WNT1 WNT2 APBB3 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 JUP FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A LRP1B AFDN ACTB-1 NECTIN1 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation ALDH1L1 MAOB MAOA ALDH1L2 ALDH4A1 ALDH3A2 ALDH3A1 ALDH1A3 IL4I1 ALDH1B1 ALDH3B2;ALDH3B1 ALDH2 ALDH1A2 ALDH1A1 ALDH16A1 ALDH8A1 ALDH7A1 ALDH9A1 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 MDM2-2 MDM4 TP63 TP53 TP73 COP1 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis ILVBL BCAT1 BCAT2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 ACSS1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 PANK3 PANK1 PPCS DCAKD METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle IREB2 ACO1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation MAPK3 PPP3CA PPP3CB BLNK VAV3 SYK IKBKB NFKBIL1 VAV1 VAV2 BTK CD79B CD79A CD19 LYN MAP3K2 MAP3K3 CALM3;CALM1 NFKBIA MAPK10 PTPRC PTPN6 GRB2 CD22 CHUK FOS SOS1 SOS2 ITPR1 ITPR2 ITPR3 MAPK14 MAPK12 MAPK13 MAPK11 ARAF PIK3CD PIK3CB PIK3CG RAC1 HRAS JUN PRKCB MAPK9 MAPK8 PRKCD PIK3CA RAF1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation IGBP1 PRKAB2 PRKAA1 PRKAA2 PRKAG1 TSC2 TSC1 PRKAB1 RPS6KB1 RHEB RPS6KB2 EIF4EBP1 PPP2CB;PPP2CA TP63 AKT2 AKT3 TP53 AKT1 TP73 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis LPL PLA1A PLCB1 PLCB2 DAGLA PLCB3 LIPH MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism GMPPB PMM1 GMDS GMPPA PMM2 MPI MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing SNRNP40 PRPF3 SNRPB2 ZRSR2-1 SNRPA HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation EGLN2 RORC MTOR ARNT TXN2 VHL TXN AKT2 HIF1A AKT3 EGLN1 CREBBP AKT1 EGLN3 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA TPK1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor GTF2A1 GTF2A2 GTF2B TAF9 TTF2 TTF1 GTF2E1 GTF2E2 PSMC3IP CREB3L3 CREB3L4 TAF1C CREB3L1 POLR2C CREB3L2 POLR2E POLR2F EP300 POLR2H TAF9B CFAP20 POLR2L TBP BRF2 TAF12 PRKAR1B BRF1 PRKAR1A MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TBPL2 TAF8 TAF7 TBPL1 TAF6 PRKAR2B TAF4 PRKAR2A TAF2 CREB5 CREBBP OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway GNAI1 GNG2 GNG10 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 OPRD1 POMC GNB2 GNB4 GNAO1 GNB3 GNB5 ADCY2 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis TGDS GFPT2 GFPT1 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis AVP OXT-1 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion LGSN GLUL GLUD1;GLUD2 UNTITLED%PANTHER PATHWAY%P00019 untitled GUCY1A2 EDN1 MAPK3 GUCY1A1 ADCY9 NOS3 EDN2 EDN3 GNAS-1 ADCY3 ADCY10 AKT2 AKT3 ITPR1 ITPR2 ITPR3 GNA14 GNA11 PLCB3 PLCB4 ARAF GNAQ PLCB1 PLCB2 PRKACB-1 AKT1 ADCY2 PRKAR1B PRKAR1A PRKCG PRKACA-1 PRKCI PRKCH PRKCB PRKCE PRKCD PLA2G4A PRKCA ADCY7 PRKAR2B PRKAR2A PRKCQ RAF1 GNAL ADCY4 PRKCZ GUCY1B1 ADCY1 EDNRA ADCY8 MAP2K2;MAP2K1 EDNRB ADCY6 PRKG2 ADCY5 MAPK1 PRKG1 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis GCH1 FPGS TYMS DHFR2;DHFR 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway PLCG1 GNA14 GNG10 GNG5 PLCZ1 GNG4 HTR2B GNA11 HTR2A GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI GNG2 PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PRKCZ PLCG2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway CSK LAMB3 LAMB2 LAMB4 LAMB1 PTPN12 COL3A1 LIMS2 BCAR1 MAP3K2 MAP3K3 MAPK10 MAP3K4 MAP2K4 MAPK13 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 HRAS MAP2K3 MAPK9 MAPK8 PIK3CA PIK3C3 RAF1 PXN PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 MAPK3 BRAF PTK2 COL16A1 COL12A1 ITGA2B ARPC5L CRKL MAP3K5 COL27A1 ACTN2 ACTN1 ACTN4 COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 ELMO1 COL8A2 COL4A5 ELMO2 ACTG1 COL8A1 TLN1 VCL COL17A1 COL13A1 ARL1 DNAJC27 RAP1B RAP1A RRAS VASP CAV1 FN1 SOS1 PARVA PARVB SOS2 ARPC5 ARHGAP26 COL1A2 LIMS4;LIMS1 ARPC2 COL5A1 ARPC3 ITGA10 MAPK6 COL5A3 ACTBL2 ITGA11 COL5A2 COL20A1 COL9A1 ITGBL1 COL9A3 COL9A2 ITGB1 ARF1 ITGAM ITGB5 ITGB4 COL14A1 LAMC3 ARPC1B ARPC1A ITGB2 ILK LAMC2 SHC1-1 LAMC1 ITGAE RND2 ITGAL RND3 RND1 ITGAX COL10A1 ITGB8 ITGAV ITGB7 ITGB6 ITGA4 ITGA3 ITGA2 ITGA1 RHOC ARFGAP1 RHOA RHOB ARHGAP10 RAP2A COL2A1 RAP2B ITGAD COL6A2 COL6A1 ITGA8 FLNA RAPGEF1 ITGA7 COL6A3 ITGA6 ACTB-1 ITGA5 CRK DOCK1 ARF6 ITGA9 LAMA5 COL15A1 LAMA2 LAMA1 SRC LAMA4 COL11A1 LAMA3 COL11A2 NTN4 ASAP1 CDC42 MICALL1 PTK2B FLNB FYN PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway EHF ARHGAP42 OPHN1 GRAP2 PDGFRB PDGFRA PDGFRL VAV3 ERF ERG SHC3 VAV1 PDGFB VAV2 PDGFA ARHGAP15 ARHGAP12 SRGAP3 SRGAP1 FLI1 MAP3K2 FEV GRAP ARHGAP9 GSK3A MAPK10 ARHGAP5 ARHGAP6 GRB2 RERG ARHGAP4 RASA4;RASA4B NCK2 JAK2 GABPA JAK1 NCK1 GAB1 GAB2 ETV3 RPS6KB1 ELF1 ELF2 RPS6KB2 ELF3 ELF4 ELF5 RASA1 RASA2 RPS6KC1 PIK3R5 SPDEF MYCBP-1 SRF ELP1 USF2 ELK1 RAB11B RPS6KA4 NIN PKN2 RPS6KA5 MKNK1 MKNK2 MAP3K4 ITPR1 ITPR2 ITPR3 MAPKAPK2 ARAF ARHGAP1 PIK3CD PIK3CB ETS1 PIK3CG ARHGAP8;PRR5-ARHGAP8 HRAS JUN MAPK8 PRKCA PIK3CA PIK3C3 RAF1 SHC2 PIK3R3 PIK3R2 PIK3R1 NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLCG1 MAPK3 BRAF GSK3B IKBKB ELK4 RPS6KA3 RPS6KA6 AKT2 RPS6KA2 MYC RPS6KA1 JAK3 CHUK PDPK1 FOS SOS1 SOS2 ARHGAP26 MAPK7 STAT4 STAT6 MAPK6 STAT5A STAT5B STAT1 STAT2 STAT3 MAPK15 SHC1-1 ARHGAP10 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway ACTC1;ACTG2 ACTG1 ACTA2 ACTA1 ACTBL2 SLC44A3 ACTR1A ACTR1B MYO18B MYO18A SLC18A3 CHRNB1 MYO7B MYO7A SLC5A7 MYH1 MYH3 MYO3B MYO3A MYH8 MYH9 MYH6 MYH7 CHRNA1 PLEKHH3 CHRNA9 CHRNA7;CHRFAM7A CHRNA2-1 CHRND CHRNG CHRNE MYO6 MYH13 MYH14 CHRNA10 CHRNA3 MYH11 MYH10 CHRNA5 MYH7B MYO10 CHRNA4 MYO5A CHRNA6 MYO19 MYO1G;MYO1D MYO9A MYO16 MYO1E MYO1B SLC6A8 MYO1C MYO1A MYO15A MYO5B MYO5C MYO1F CHRNB2 CHRNB4 ACTB-1 CHRNB3 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway STAT4 JAK2 STAT6 JAK1 STAT5A STAT5B STAT1 JAK3 STAT3 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SUGCT SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PSAT1 PHGDH PSPH AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin PLCG1 PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B RAC1 VASP PIK3CA NTN1 NTN3 ABLIM1 NTNG1 NTNG2 UNC5B PIK3R5 DCC NFATC3 NFATC2 PIK3R3 UNC5C PIK3R2 UNC5D PIK3R1 NFATC4 NTN4 RHOU CDC42 PLCG2 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis SLC18A1 SLC6A2 SLC6A3 SLC18A2 SLC6A19 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A20 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation CYP2A13;CYP2A6;CYP2A7-1 FMO3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 INMT COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SUGCT S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis MAT2A MAT1A MTR-1 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase MYLK2 BUB1B-PAK6;PAK6 STMN4 WASL MYLK3 MYLK CFL2 CFL1 STMN1 TUBB1 TUBB2B;TUBB2A PFN1 PFN2-1 TUBB3;TUBB6 PFN3 ROCK1 ROCK2 PAK1 PAK3 ACTC1;ACTG2 PAK2 PAK5 PAK4 LIMK1 ACTG1 ARPC4 TUBB4B DIAPH1 DIAPH2 TUBB4A;TUBB;TUBB8B;TUBB8 ARPC5 ACTA2 ARPC2 ACTA1 ARPC3 ACTBL2 MYH1 MYH3 ARPC1B MYO3B ARPC1A MYO3A MYH8 MYH9 MYH6 MYH7 MYH13 MYH14 MYH11 MYH10 MYH7B RHOC RAC1 ACTB-1 RHOU CDC42 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade MAPK3 IRS1 IRS2 RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 MAP2K3 IRS4 IGF1R INS;INS-IGF2 INSR FOS INSRR IGF2 RPS6KB1 IGF1 IGF2R RPS6KB2 SOS1 SOS2 RASA1 RAF1 ELK1 RPS6KA4 RPS6KA5 MAP2K2;MAP2K1 MAPK1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway JAK2 JAK1 STAT1 IFNG IFNGR1 IFNGR2 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 DDC TPH1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UCK1 NME4-1 NME2 NME3 UPRT UPP1 ADAT2 UCKL1 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway GRIA1 GRIA2 SNAP25 ADCY10 GRIK5 SLC1A1 SNAP23 GRIK3 SLC1A2 GRIK4 SLC1A3 GRIK1 GRIK2 SLC1A6 SLC1A7 GRIN2A SNAP29 GRIA3 GRIA4 GRIN2C GRIN2B GRIN2D GRIN1 VAMP8 GRIN3A VAMP1 VAMP2 VAMP3 GRM4 GRM7 GRM6 GRM8 CACNB1 STX1A CACNA1E VTI1A SLC17A7 GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX GRM1 PRKACB-1 GRM5 PRKAR1B PRKAR1A GNAI1 PRKACA-1 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 CACNA1B CACNA1A APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway MAPK3 IKBKB MAP3K5 AKT2 AKT3 NFKBIA MAPK10 CHUK FOS IGF2R ATF1 TP53 MAP2K4 ATF2 TRADD FASLG TNF CASP7 CASP8 AIFM1 CASP10 CASP3 TNFSF10 GZMH;GZMB-1 MAP4K2 DAXX ENDOG APAF1 TRAF2 PIK3CD TNFRSF1B PIK3CB TNFRSF1A GZMH-1 MADD PIK3CG LTA LTB CASP9 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ATF6 ATF3 JDP2 AKT1 BIRC2 ATF4 BIRC3 PRKCG ATF6B MAP2K3 CREM PRKCH XIAP JUN PRKCB RELA RELB CYCS-1 MAPK9 PRKCE MAPK8 BCL2L11 PRKCD RIPK1 BAK1 BCL2 PRKCA FADD PIK3CA MAP2K7 MAP4K3 MAP4K4 MAP3K1 PRKCQ CRADD BIK EIF2AK2 DIABLO-1 EIF2S1 NFKB1 NFKB2 ATF7;ATF7-NPFF PRKRA REL BAX FAS MAP3K14 BCL2L1 MAPK1 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis BCAT1 BCAT2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway EXOC2 RALB MAPK3 PLD1 PLD2 BRAF RALGDS RGL1 GSK3B RPS6KA3 RPS6KA6 RPS6KA2 RPS6KA1 AKT3 PAK1 PAK3 PAK2 GSK3A MAPK10 GRB2 PDPK1 SOS1 SOS2 SRF ELK1 STAT1 KRAS STAT3 MAP3K4 MAP2K6 MAP2K4 ATF2 MAPK14 MAPK12 MAPK13 MAPK11 MAPKAPK3 SHC1-1 MAPKAPK2 ARAF PIK3CD PIK3CB ETS1 PIK3CG RHOC RAC3 RHOA AKT1 RHOB RAC1 HRAS MAP2K3 JUN MAPK9 MAPK8 PIK3CA MAP2K7 PIK3C3 MAP3K1 RAF1 CDC42 NRAS MAP2K2;MAP2K1 MAP3K7CL RALA-1 MAPK1 TIAM1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin MAPK3 ITPR1 ITPR2 ITPR3 ARRB1 GNG10 ARRB2 GRK3 GRK2 GNG4 EGR1 AGT GNG8 AGTR1 PLCB3 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PRKCA GNB1 RAF1 ELK1 MAP2K2;MAP2K1 MAPK1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation GTF2A1 GTF2A2 GTF2B TAF9 TTF1 GTF2E1 GTF2E2 TAF1C POLR2C POLR2F POLR2H TAF9B CFAP20 BRF2 TAF12 BRF1 MTERF2 TAF11 GTF2H1 GTF2F1 GTF2H3 GTF2F2 GTF2H4 TAF8 TAF7 TBPL1 TAF6 TAF4 TAF2 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway MDM2-2 MDM4 CDKN1A HDAC1 CCNB1 WRN SUMO1 SIN3A CHEK2 SUMO3 TRAF2 SUMO2 HMGB1-1 AKT2 SFN MTA2 EP300 GTSE1 CDKN2D AKT3 GADD45B CDKN2A GADD45A CDC25C AKT1 SIRT1 PML GADD45G KAT2B KAT6B CDK1 PDPK1 PIK3CA CCNE1 PTEN TP63 TPTE;TPTE2 CDK2 ATM TP53 CREBBP TP73 ATR THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway PLCG1 SNAP25 SNAP23 SNAP29 VAMP8 VAMP1 TRH TSHB VAMP2 TRHR CACNB2 VAMP3 CACNB3 CACNB4 STX3 CGA CACNB1 CACNA1E GNA14 GNG10 GNG5 PLCZ1 GNG4 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 PLCB1 PLCB2 PLCD4 PLCD1 PRKCG PRKCI PRKCH GNG2 PRKCB PRKCE PRKCD PRKCA PRKCQ GNB1 CACNA1B CACNA1A PRKCZ PLCG2 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis HSD17B3 HSD17B6 HSD17B7 LIPA CYP19A1 SOAT1 SOAT2 HSD17B1 HSD17B2 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway CTNND2 CTNND1 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CTNNB1 CDH8 CELSR3 CDH7 CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 PCDHGA11 PCDHGA12 FER PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 FAT2 DCHS1 FAT3 PCDHB3 PCDHB7 PCDHGB7 PCDHGB6 PCDHGB2 PCDHA8;PCDHA6-1 PCDHGA8 PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PCDHGA2 PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PTPN1 PCDH9 PCDH7 PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 ACTC1;ACTG2 WNT2B FZD10 ACTG1 CDH3 CDH1 ACTR2 WNT5B WNT5A WNT9B WNT9A WNT16 ACTA2 ACTA1 ACTBL2 LEF1 WNT8A WNT8B FSTL1 WNT6 WNT11 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A ACTB-1 UNTITLED%PANTHER PATHWAY%P06664 untitled RELA SKIL TGIF1-1 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation AOC3 AOC1 AOC2 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle OGDH SUCLG1 SDHC ACO2 PDK2 CS FH PDHA1 MDH1 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B ATP5F1C ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation ODC1 AZIN2 AZIN1-2 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion PCCB ECHDC1 MMUT LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIAS PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism NT5E DPYSL5 ABAT DPYSL2 DPYS DPYD DPYSL3 UPB1 CDA ALDH6A1 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation RPE;RPEL1 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway PRKACA-1 GNG2 GNG10 ADRB1 GNG5 GNG4 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade MDM2-2 MDM4 PDPK1 IRS4 IGF1R GSK3B TSC2 INS;INS-IGF2 INSR TSC1 INSRR FOXO1-1 IGF2 IGF1 PIK3CA IRS1 IGF2R IRS2 FOXO3 PTEN TPTE;TPTE2 GSK3A HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway PRKACA-1 GNG2 GNG10 GNG5 GNG4 HRH2 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway GNG2 GNG10 GNG5 GNG4 ADCY7 ADRB3 GNG8 GNB1 GNB2 GNB4 GNB3 GNB5 GNAL ADCY2 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism NT5E GDA AMPD3 XDH METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis MTR-1 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway GNG2 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 CRHR1 GNB1 CRHR2 POMC GNB2 CRH GNAQ GNB4 GNB3 GNB5 GNAL ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway MAPK3 APP MAPK10 KAT5 PSENEN CACNB2 MAPK7 ADAM17 PKN3 BACE1 CACNA1D CACNA1F BACE2 KLC1 MAPK6 KLC4 KLC3 KLC2 PKN2 CACNA1S MAPK4 APBA1 PKN1 APBA3 CACNB1 APBA2 MAPK15 PSEN2 MAPK14 PSEN1 MAPK12 MAPK13 MAPK11 NCSTN APH1B CHRNA7;CHRFAM7A CACNA1C PRKCG PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PRKCQ PRKCZ MAPK1 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis CBS;CBSL AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo CXCR4 ROBO1 CXCL12 ABL1 SLIT1 SLIT3 SLIT2 NTN1 NTN3 NTNG1 NTNG2 DCC SRGAP1 NTN4 RHOC CDC42 RAC1 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis NME4-1 NME2 NME3 CPS1 CAD CTPS2 CTPS1 DSCAML1 DHODH NME1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway PLCG1 MAPK3 BRAF MAP3K5 SHC3 AKT2 MAP3K2 AKT3 MAP3K3 GRAP MAPK10 RASA4;RASA4B GAB1 GAB2 RRAS SOS1 SOS2 RASA1 RASA2 PIK3R5 STAT4 STAT6 STAT5A STAT5B STAT1 STAT2 STAT3 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 ERBB4 PEBP1 PEBP4 RRAS2 ARAF GAB3 MRAS PIK3CD PHLDB2 PIK3CB RASAL2 PIK3C2A EGFR ERBB3 PIK3CG ERBB2 PIK3C2B SPRY4 DAB2IP SPRY3 NF1 SPRY2 AKT1 SPRY1 RAC1 HRAS PRKCG MAP2K3 PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PIK3CA MAP2K7 PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 SHC2 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade FGA SERPINB2 MMP1 MMP3 FGG SERPINE1 SERPINF2 PLAUR PLAT PLG MMP9 MMP13 PLAU FGB PNAT%PANTHER PATHWAY%P05912 PNAT SLC6A3 SNAP25 GNG4 SNAP23 GNG8 GNB2 GNB4 GNB3 KCNK9 SNAP29 EPB41 PRKX PRKACB-1 ADCY2 GNAI1 VAMP8 PRKACA-1 VAMP1 EPB41L1 EPB41L2 VAMP2 FLNA DRD2 VAMP3 DRD4 SLC18A2 GNAI3 STX3 ADCY7 GNAI2 GNAZ PRKAR2B PPP1CA PPP1CC PRKAR2A PPP1R1B DRD1 GNB1 DRD5 KCNK3 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway SHH SMO STK36 FBXW11 PTCH1 BTRC GLI1 GLI3 CREBBP MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway SLC5A7 GNG10 ADCY10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX PRKACB-1 PRKAR1B GNAI1 PRKAR1A PRKACA-1 SLC6A8 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 GNAO1 CHRM2 CHRM4 GNAT2 GNAT1 KCNJ5 KCNJ6 KCNJ3 SLC18A3 KCNJ9 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism GNPDA1 GNPDA2 AMDHD2 NPL GFPT2 GFPT1 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway MAPK3 ACVRL1 BMP10 BMPR2 MSTN SKIL AMHR2 CITED1 CITED2 TGFBR1-1 BMP15-1 BMP8A;BMP8B SNIP1 JUNB ACVR1 LEFTY2;LEFTY1 FOXH1 TGFBR2 ACVR1B ACVR1C SMAD2;SMAD3 GDF10 SMAD1 GDF11 SMAD4 TGFB2 JUND SMURF2 MAPK10 GDF15 TGFB3 SMURF1 GDF2 BMP8B GDF1 SMAD9 INHBB GDF3 INHBA GDF6 RRAS SMAD6 BMP7 GDF5 INHBC SMAD5 ACVR2B BMP6 ACVR2A INHBE BMP5 SMAD7 GDF7 BMP4 FOSL1 SKI BMP3 GDF9 BMP2 BMP1 GDNF TLL2 CREBBP TLL1 MAP3K7 BMPR1B NODAL BMPR1A DCP1B ATF2 MAPK14 MAPK12 MAPK13 MAPK11 TAB1 EP300 HRAS JUN MAPK9 MAPK8 NRAS MAP3K7CL MAPK1 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation PROS1 TFPI KNG1 THBD VWF F10 GP1BB F12 F2R GP1BA F2 GP5 ITGA2B F3 GP9 PROCR F7 F8 F9 PROC F13B KLKB1 F2RL3 FGB FGA FGG PLAUR PLAT PLG PLAU PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway NOS3 GNA14 GSK3B GNA11 IRS1 GNB2 GNAQ GNB4 GNB3 PIK3CB GNB5 AKT2 PTGER1 FOXO4 CASP9 AKT3 GNGT1 YWHAZ AKT1 GNAI1 PDPK1 INSR FOXO1-1 GNAI3 RPS6KB1 PIK3CA GNAI2 RPS6KB2 SOS1 SOS2 GNB1 FOXO3 PIK3R5 PIK3R3 PIK3R2 PIK3R1 NRAS GNAT2 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway GRM3 GRM2 CALM3;CALM1 GSK3A CREBBP GNG10 HRH1 GNG5 GNG4 GNG8 CREB3L3 CREB3L4 GNB2 CREB3L1 CREB3L2 EP300 GNGT1 GRM1 CHRM3 PRKACB-1 CHRM1 GRM5 CHRM5 PRKAR1B HTR6 PRKAR1A HTR7 ADORA3 ADORA1 PHKA1 PHKA2 MTNR1A MTNR1B ADRB2 HRH3 CLTCL1 GNAI3 HRH4 ADCY7 PHKB GNAI2 PRKAR2B PYGB PRKAR2A CLTC HTR1E CLTB CREB5 HTR1F CLTA OPRD1 HTR1D PYGM HTR1A ADRA1D HTR1B PYGL ADRA1B ADRA1A HTR4 GYS2 GNAL GYS1 GNRHR ADCY4 SSTR1 OPRM1 SSTR2 ADCY1 ADRA2C ADCY8 SSTR3 ADCY6 ADRA2B ADCY5 SSTR4 KCNJ3 SSTR5 CREB3 ADCY9 CREB1 ADORA2A ADORA2B OPRL1 ADCY3 PHKG1 GSK3B PHKG2 OPRK1 GPR50 HTR5A HTR2B HTR2A RAP1B ADRB1 RAP1A HRH2 ADRB3 GRM4 GRM7 GRM6 GRM8 ADCY2 GNAI1 CREM PRKACA-1 GNG2 DRD2 DRD4 DRD1 GNB1 DRD5 CHRM2 CHRM4 KCNJ5 KCNJ6 KCNJ9 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway PLCG1 MAPK3 MAP3K6 FRS2 FRS3 FGFR4 FGFR3 FGFR2 FGFR1 MAP3K5 SHC3 AKT2 MAP3K2 AKT3 MAP3K3 GRAP MAPK10 PTPN6 RASA4;RASA4B SOS1 SOS2 RASA1 RASA2 MAP3K4 MAP2K6 MAP2K4 MAPK14 MAPK12 MAPK13 MAPK11 SHC1-1 PEBP1 ARAF PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B SPRY4 SPRY3 SPRY2 AKT1 SPRY1 RAC1 HRAS PRKCG MAP2K3 PRKCI PRKCH PRKCB MAPK9 PRKCE MAPK8 PRKCD PRKCA PIK3CA MAP2K7 PIK3C3 PRKCQ RAF1 PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis ASL NAGS ASS1 OTC CPS1 CAD HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB5 CALML3 PDC GRK1 RHO CNGA1 GNGT1 PDE6B CALM3;CALM1 CNGA3 PDE6A RGS9 RCVRN GNG13 CNGB3 CNGB1 GNG2 GNB1 GNAT1 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT1 BCAT2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease MAPK15 PSMA1 MAPK3 TH SLC6A3 CCNE2 PLD2 MAPK14 MAPK12 SFN YWHAZ MAPK10 YWHAE PRKN YWHAB PPP1R8;STX12 MAPK9 PSMA7 MAPK8 PSMB10 PSMA8 PSMB7 YWHAQ PSMB3 CCNE1 PSMB1 NDUFV2 YWHAG YWHAH MAPK7 SNCA GPR37 SEPTIN1 SEPTIN2 STX7 SEPTIN5 ELK1 CASK GPR37L1 SNCAIP SEPTIN4-1 PSMA2-1 PSMA5 PSMA6 MAPK1 PSMA3 PSMA4 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway ITPR1 ITPR2 SLC5A7 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB4 GNB2 GNAQ GNB4 GNB3 GNB5 GRIN2A CHRM3 GRIN2C CHRM1 GRIN2B GRIN2D GRIN1 PRKCG PRKCI GRIN3A PRKCH PRKCB PRKCE PRKCD PRKCA GNB1 PRKCQ PKN3 PKN2 PRKCZ PKN1 SLC18A3 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway GNAI1 PDYN GNG2 PENK GNG10 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 OPRD1 GNB2 GNB4 GNB3 GNB5 ADCY2 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication RFC5 TOP2A TOP2B RFC3 RFC4 PCNA RFC1 RFC2 PRIM1 RPA2 POLA1 POLD1 POLD2 TOP1 DNA2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway MCEE PCCA PCCB MMUT DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis DSCAML1 NME1 AK1 AK2 GMPS AK3 AK5 AK8 ATIC GUK1 PPAT AK4-1 ADSL RRM1 NME5 RRM2B NME6 NME7 IMPDH2 ADSS1 ADSS2 RRM2-1 GART NME4-1 NME2 NME3 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway F13B RXRA VDR RARA GC HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway SSTR5 ADORA2A ADORA2B OPRL1 OPRK1 GRM3 GRM2 GNG13 DNAJC27 RAP1B RAP1A GRM4 GRM7 GRM6 GRM8 CACNA1E ITPR1 ITPR2 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 PLCB1 PLCB2 GNGT1 GRM1 CHRM3 RHOA CHRM1 GRM5 CHRM5 PRKCG ADORA3 PRKCI ADORA1 PRKCH GNG2 PRKCB PRKCE DRD2 PRKCD DRD4 PRKCA CLTCL1 CLTC CLTB PRKCQ DRD1 GNB1 CLTA BDKRB2 OPRD1 DRD5 BDKRB1 GARNL3 ARHGEF1 GPR45 GNAO1 RASGRP2 RASGRP1 RASGRP4 GNRHR RAP1GAP CHRM2 SSTR1 CACNA1B RASGRP3 CHRM4 OPRM1 CACNA1A PRKCZ SSTR2 SSTR3 SSTR4 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis DOK2 DOK3 EPHA3 PLD1 GRB7 PLD2 TCF7 EFNB2 EFNB1 PDGFD PDGFC JAG2 JAG1 APC2 PLA2G4D PDGFRB AXIN1 PDGFRA BIRC5 GRB14-1 DLL1 DLL3 DLL4 PDGFB ANGPT1 PDGFA DLK1 APC TEK GRAP NCK2 JAK1 NCK1 RASA1 HSPB1 CTNNB1 MAP2K4 MAPK14 MAPKAPK3 F2R MAPKAPK2 PRR5 TGFB1I1 ARAF ARHGAP1 PIK3CD PIK3CB PIK3C2A ETS1 PIK3CG PIK3C2B CASP9 ARHGAP8;PRR5-ARHGAP8 KDR AKT1 HRAS PRKCG PRKCI PRKCH JUN PRKCB SPHK2 SPHK1 PRKCE MAPK8 PRKCD PLA2G4A PRKCA PIK3CA PRKD3 PRKD2 PIK3C3 PRKCQ PRKD1 RAF1 CRYAA;CRYAA2 CRYAB SHC2 PXN PIK3R3 PIK3R2 PIK3R1 HIF1A PRKCZ NRAS MAP2K2;MAP2K1 PLCG2 MAPK1 LPXN PLCG1 MAPK3 NOS3 BRAF PTK2 VEGFA GSK3B FRS2 FRS3 CRKL FGFR1 AKT2 AKT3 PAK1 PAK3 PAK2 WNT2B RBPJ FOS WNT5B SOS1 WNT5A SOS2 RBPJL NOTCH2 STAT1 NOTCH1 NOTCH4 STAT3 SHC1-1 DVL1 DVL2 DVL3 WNT1 WNT2 FZD1 TCF7L2 WNT10B RHOC WNT10A FZD3 RHOA FZD2 RHOB FZD5 WNT7B WNT7A CRK MAP3K1 SRC FGF1 JMJD7-PLA2G4B;PLA2G4B EPHB2 EPHB1 EPHB3 DOK1 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis RRM1 RRM2B NME4-1 NME2 NME3 DTYMK DUT ADAT2 RRM2-1 TYMS DSCAML1 NME1 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking LOC102724488;SYT15 STX1A STXBP1 SYT7 UNC13D VAMP1 SYT6 RIMS1 SYT12 SNAP25 SYT11 STX2 SYT5 UNC13B UNC13C SYT3 SYT2 RAB3A SYT1 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 ARRB2 BCAR1 EGR1 PPP3CA LYN CALM3;CALM1 NFKBIA MAPK10 GRB2 JAK2 CLU IER3 RPS6KB1 RPS6 RHEB PTGS2-2 CETP EIF4EBP1 ARHGEF28 MAP2K5 YES1 SP1 SP3 SNAI1 TCF4 MAP3K11 SRF RYR1 HSPB1 ELK1 RYR2 ELAVL1 RYR3 CD38 CTNNB1 GAST NOS1 CCKBR EIF4E AKT1S1 MEF2D PPARG HBEGF MAP2K6 GUCY2D MAP2K4 ITPR1 NR2C2 MEF2C AKAP1 HDAC7 BAD MAPK14 MEF2B;BORCS8-MEF2B PTPN11 CCK TPCN2 TPCN1 CAMK4 TRAF6 ARAF PIK3CB PRKACB-1 AKT1 RAC1 PRKCH JUN PRKCB MAPK9 PRKCE MAPK8 PRKCD BCL2 PLA2G4A PRKCA PRKD2 PRKCQ PRKD1 RAF1 PXN NFATC2 PIK3R1 ADCY1 MAP2K2;MAP2K1 MAPK1 PRKG1 PLCG1 MAPK3 CREB1 BRAF PTK2 GSK3B CXCL8 IRS1 ELK4 RPS6KA3 ODC1 ROCK1 RPS6KA1 PAK1 CDH1 PDPK1 YWHAB FOS FOXO1-1 SOS1 FOXO3 MAPK7 ITGB1 STAT3 ATF2 SHC1-1 CASP3 ITGAV RHOA CREM PRKACA-1 MMP3 GNG2 SLC18A2 PLAU CRK GNB1 SRC BAX MAP3K14 CDC42 BCL2L1 PTK2B GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis GPI HKDC1 HK2 HK1 TPI1 PKLR PGAM2 BPGM ENO1 ENO2 PFKL GAPDH-1 ALDOA PKM PGK1 PFKM NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway JAG2 JAG1 DLL3 DLL4 DLK1 MAML1 NCOR2 NUMB RBPJL CIR1 NOTCH2 NOTCH3 NOTCH1 NOTCH4 RBPJ GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis ABAT ALDH5A1 GAD1 GAD2 CSAD FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway MAP2K4 FASLG CASP7 CASP8 CASP10 CASP3 DAXX MAP3K5 APAF1 CASP9 MAPK10 FAF1 CAPG LMNB2 LMNB1 SCIN CASP6 JUN LMNA DFFB MAPK9 PARP3 MAPK8 GSN PARP4 PARP1 FADD PARP2 CFLAR FAS INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway JUNB VAV1 GRAP JUND JAK2 KRAS ITPR1 ITPR2 ITPR3 MYH1 MYH3 GNA14 GNG10 MYO3B VWF MYO3A MYH8 GNG5 PLCZ1 MYH9 MYH6 GNG4 MYH7 GNA11 GNG8 PLCE1 PLCL1 PLCB3 PLCB4 ARAF GNAQ GNB3 PIK3CD MYH13 PIK3CB MYH14 PLCB1 PLCB2 MYH11 PIK3CG PLCD4 MYH10 PLCD1 MYH7B PRKX PRKACB-1 AKT1 RAC1 JUN PRKCB PRKCE GNAI3 PIK3CA PREX1 GNAI2 CCRL2 PF4;PF4V1-1 LTB4R2 CCL3L1;CCL3L3;CCL3;CCL18 RAF1 IFNAR1 CCL13;CCL2 C5AR1 FPR1 NFATC3 GNAO1 CCR10 NFATC2 CCR1 XCR1 NFATC1 NFATC4 CXCL10 PRKCZ CX3CL1 CCR9 NRAS CCR8 PLCG2 CCR7 ADCY6 CCR6 ADCY5 MAPK1 CCR5 PLCG1 CCR4 CCR3 MAPK3 CCR2 RHOG CX3CR1 NFAT5 CAMK2D CCL11 CAMK2A MYLK2 CXCL8 CXCR5 BUB1B-PAK6;PAK6 CXCR6 CCL4L2;CCL4L1;CCL4 CCL8 MYLK3 CCL5 COL12A1 MYLK CXCR3 CCL22 ARPC5L CCL21 IKBKB CCL20 CCL27 CCL26 AKT2 ROCK1 AKT3 PAK1 PAK3 ACTC1;ACTG2 PAK2 PAK5 PAK4 ACTG1 ARPC4 CHUK PDPK1 RRAS SOS1 IFNG ARPC5 CXCR1 ARPC2 ACTA2 CXCR2 ARPC3 ACTA1 CASK ACTBL2 COL20A1 ITGB1 STAT3 CXCR4 IL2 COL14A1 ARPC1B ARPC1A SHC1-1 ITGAL ITGB7 RHOC RHOA ADCY2 GNAI1 PRKACA-1 GNG2 COL6A2 RELA COL6A1 RELB COL6A3 ACTB-1 NFKB2 CDC42 PTK2B XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway HPRT1 PNP-1 PRTFDC1 GDA HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease RHOG GRIK5 GRIK3 GRIK4 ARPC5L GRIK1 GRIK2 TUBB1 TUBB2B;TUBB2A TUBB3;TUBB6 CYFIP2 GRIN2A CYFIP1 HIP1 AP2A1 AP2A2 ACTC1;ACTG2 CAPN9 CAPNS1 GRIN2C CAPN6 GRIN2B CAPN7 GRIN2D ACTG1 CAPNS2 GRIN1 CAPN5 TUBB4B CAPN2 GRIN3A CAPN3 CAPN1 TUBB4A;TUBB;TUBB8B;TUBB8 IFT57 DYNC2H1 DNAI2 ACTR2 FOS DYNC1LI1 DYNC1LI2 RHOJ GAPDHS HAP1 RHOQ DNAH3 DYNC1I2 ARPC5 DNAH7 DCTN1 SP1 DNAH8 ACTA2 DNAH5 TP63 HTT ACTA1 KALRN CYC1 ACTBL2 DYNC1I1 DYNC1H1 BDNF HIP1R CAPN11 CAPN12 TP53 CAPN10 CREBBP DLG4 TP73 DNAL4 MAP2K4 ARPC1B ARPC1A CASP8 CASP3 MAP3K10 GAPDH-1 APAF1 EP300 TBP RAC1 JUN MAPK9 MAP2K7 ACTB-1 TAF4 CLTB CDC42 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALLC PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism ACLY PC PKM ME1 PCK1 CLYBL CS PKLR PDHA1 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation PLCG1 MAPK3 BRAF PPP3CA GRAP2 PPP3CB VAV3 IKBKB VAV1 VAV2 AKT2 AKT3 PAK1 PAK3 CALM3;CALM1 PAK2 NFKBIA PTPRC CHUK NCK2 NCK1 FOS SOS1 SOS2 ITPR1 CD86 CD80 CD3G CD3E CD3D PPP3CC ZAP70 LCK LCP2 CD28 CD247 LAT ARAF PIK3CD PIK3CB PIK3CG AKT1 RAC1 HRAS JUN MAPK9 MAPK8 PIK3CA PIK3C3 MAP3K1 PRKCQ RAF1 PIK3R3 PIK3R2 PIK3R1 CDC42 NRAS MAP2K2;MAP2K1 MAPK1 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway MAPK3 MAPK14 TRAF6 TAB1 IKBKB ECSIT TANK TBK1 IRAK1 MAP3K8 IKBKE TICAM2 IRAK4 TICAM1 TIRAP NFKBIA IRF3 TOLLIP TLR9 TLR8 TLR7 TLR10 MAP2K3 CHUK TLR6 JUN NFKBIE TLR4 TLR3 MAPK9 MYD88 MAPK8 TLR2 ELK1 MAP2K2;MAP2K1 MAP3K7 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism PDXK PSAT1 PNPO WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway TBL1Y CTNNA3 CTNNA2 CSNK1A1 TLE4 CSNK1G3 TLE3 TLE2 TLE1 CHD1L TLE6 PYGO1 PYGO2 TBL1XR1 CSNK1G2 EP400 BCL9 PPP2R5E DACT1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C ARID1A SMAD1 SAG SMARCD1 SMAD4 SMARCD2 HDAC2 SMARCD3 HDAC3 HDAC8 CTNNAL1 SMARCE1 SMAD5 PPP2CB;PPP2CA SIAH1 CTNNB1 ITPR1 ITPR2 ITPR3 GNA14 GNG10 GNG5 GNG4 GNA11 GNG8 PLCB3 PLCB4 GNB2 GNAQ GNB4 GNB3 PLCB1 PLCB2 NFATC3 NFATC2 NFATC4 WNT2B FZD10 GNG13 CDH3 CDH1 WNT5B WNT5A WNT9B WNT9A WNT16 LEF1 LRP5 WNT8A WNT8B FSTL1 LRP6 WNT6 WNT11 DVL1 DVL2 DVL3 WNT1 WNT2 WNT3 WNT4 FZD1 TCF7L2 WNT10B TCF7L1 WNT10A FZD3 FZD2 FZD5 WNT3A FZD4 WNT7B FZD7 FZD6 FZD9 FZD8 WNT7A ARRB1 ARRB2 PPP3CA PPP3CB AXIN1 HDAC1 PCDHB9;PCDHB10 CELSR1 CDH9 CELSR2 CDH8 CELSR3 CDH7 CREBBP CDH6 CDH5 CDH4 CDH2 PCDHGC4;PCDHGC3 PCDHAC1 PCDHA13 PCDHA11 PCDHA10 PCDHB4-1 PCDH10 PCDH15 PCDH12 PCDH19 PCDH18 PCDHA1 CDH20 CDH22 PCDHA5 CDH23 PCDHA4 CDH24 PCDHA3 PCDHGB5;PCDHGB4 PCDH11X;PCDH11Y PCDH20 PCDHGA10 EP300 PCDHGA11 PCDHGA12 PCDHB2 PCDHB1 PCDHB11;PCDHB12 PCDHB6 FAT1 PRKCG FAT2 PRKCI DCHS1 PRKCH FAT3 PRKCB PCDHB3 PCDHB7 PCDHGB7 PRKCE PCDHGB6 PRKCD PCDHGB2 PCDHA8;PCDHA6-1 PRKCA PCDHGA8 PCDHGA7 PCDHGA5 PCDHGA3 PCDHA7;PCDHA9 PRKCQ PCDHGA2 PCDHGA1 CDHR1 CDH10 CDH11 CDHR2 CDH12 PCDHGB1 CDH13 NFATC1 CDH15 CDH16 PRKCZ CDH17 CDH18 CDH19 PCDHB13;PCDHB8 PCDH1 PCDH9 PCDH7 PCDH8 PCDHB15 PCDHB14 PCDHB5-1 PCDHB16 GSK3B PPP3CC GNG2 SMARCAL1 SMARCB1 ARR3 SMARCC1 SMARCC2 CSNK2A2 CSNK2B GNB1 SRCAP NLK PPP3R1 HLTF SIAH2 FBXW11 SMARCA5 TPTEP2-CSNK1E;CSNK1E BTRC CSNK1D INO80 SMARCA1 SMARCA2 SMARCA4 ANKRD6 HELLS KREMEN1 KREMEN2 CSNK2A1;CSNK2A3 CTNNA1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway ADA APRT HPRT1 PNP-1 PRTFDC1 XDH TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism LIPE LIPC METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway STX1A CACNA1E GNG10 SNAP25 ADCY10 GNG5 GNG4 SNAP23 GNG8 GNB2 GNB4 GNB3 GRM3 GNB5 GRM2 SNAP29 PRKX PRKACB-1 PRKAR1B GNAI1 PRKAR1A VAMP8 PRKACA-1 VAMP1 VAMP2 VAMP3 GNAI3 GNAI2 PRKAR2B PRKAR2A GNB1 GNAO1 CACNA1B CACNA1A GNAT2 CACNB1 UNTITLED%PANTHER PATHWAY%P05916 untitled GNAI1 PDYN GNG2 GNG10 OPRK1 GNG5 GNAI3 GNG4 ADCY7 GNAI2 GNG8 GNB1 GNB2 GNB4 GNAO1 GNB3 GNB5 AVP OXT-1 ADCY2 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins DPYSL5 DPYSL2 DPYS NRP1 SEMA4D SEMA3A CRMP1 CDK5 DPYSL4 FES PLXNA1 PLXNB1 FRK ARHGEF1 PAK1 RHOA FYN RAC1 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling GNAI1 CACNA1G GNG5 GNAI3 GNG4 GNG8 PLCB3 CNR1 GNB1 GNB2 GNB4 GNAO1 GNB3 PLCB1 PLCB2 CACNA1B CACNA1A GRM1 GRM5 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I TBPL2 TAF8 TBPL1 TTF1 PSMC3IP RRN3 CAVIN1 TAF1B TAF1C POLR1B TAF1A UBTF POLR1D TBP PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway PDXK PNPO SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides TK1 ADAT2 CDA BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway PRKACA-1 GNG2 GNG10 ADRB2 GNG5 GNG4 ADCY7 GNG8 PRKAR2B PRKAR2A GNB1 GNB2 GNB4 GNB3 GNB5 GNAL PRKX PRKACB-1 ADCY2 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release CREB1 PDYN PENK GNG10 GNG5 GNG4 GNG8 GNB2 GNB4 GNB3 GNB5 PRKX PRKACB-1 ADCY2 GNAI1 CREM PRKACA-1 GNG2 GNAI3 ADCY7 GNAI2 PRKAR2B PRKAR2A GNB1 OPRD1 GNAO1 GNAL OPRM1 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis ASNS ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway PRKCG ITPR1 PRKCE PRKCD PRKCA GNA11 PLCE1 PLCB3 PLCB4 ADRA1B ADRA1A PLCB1 PLCB2 ADRA2A ADRA2C ADRA2B LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome AKR1B1 DHFR2;DHFR PTS CBR1-1 GCHFR QDPR GCH1 SPR TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId SLC35A2 UGP2 CANT1 B4GALT1 GALT CMPK1 SLC2A1 NME2 LALBA G6PC1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 NFKBIA IKBKB CD40LG TRAF3 TRAF6 IKBKG CD40 MAP3K1 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PDHA1 PCK1 AKR1B1 PC DLD CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS D2HGDH PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway NOS3 RALBP1-1 AKR1A1 POR NDUFS7 SLC22A16 NDUFS3 NDUFS2 XDH ABCG2 CBR3 CBR1-1 NQO1 ABCC1 ABCB1 ABCC2 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling AMT ASNS GLUL ASRGL1 GLS2 GLUD1;GLUD2 HAL SDS CPS1 GLDC AQP8 DLD TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages RAF1 HRAS CACNA1C MAPK3 NFKB1 NFKBIA PRKCB ITPR1 PLCB1 PRKCA CACNA1D CACNA1F RELA MAP2K2;MAP2K1 MAPK1 CACNA1S CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism FIG4 INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis MAT2B SRM MAT2A ODC1 SMS AMD1 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation GLO1 LDHD HAGH FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway DCK NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 RRM1 CMPK1 RRM2-1 CTPS1 TYMS PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 EPHX1 CYP1A2 HYOU1 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 CYP2E1 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NQO1 COMT TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis SLC35A2 UGP2 CANT1 B4GALT1 GALT CMPK1 SLC2A1 NME2 LALBA G6PC1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism DCTD NT5C2 RRM2B CDA DUT CANT1 DPYS NME6 CAD AK3 UPB1 RRM2-1 UCKL1 TYMP DHODH ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) HADH ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 ACADL ACADS TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 QARS1 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCB1 ABCC2 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency RPE65 DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 RETSAT ADH1C;ADH1B;ADH1A RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 ABCD2 HACL1 SLC27A2 PHYH-4 ABCD1 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency DCTD NT5C2 RRM2B CDA DUT CANT1 DPYS NME6 CAD AK3 UPB1 RRM2-1 UCKL1 TYMP DHODH ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis DCT TYR PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism FARSA FAH GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD TAT PAH NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria HADH ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone ADCY2 PRKACB-1 GNGT1 CREB1 FSHR CGA PPP1CA GNAS-1 GNB1 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism ACSM1 ACSM2A;ACSM2B GLYAT PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) AGPAT5-1 CRLS1 CDS2 PGS1 GPAM PTPMT1 GPD1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SLC22A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ABCC2 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 TPTEP2-CSNK1E;CSNK1E CLOCK CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins PLCB1 GNGT1 TUB GNAQ CHRM1 GNB1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid EPRS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway AGTR1 ACE REN AGT GNG2 GNAQ GNB1 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A FARSA RPL9 RPL6 RPL7 FARSB RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway GSTP1 GSTT1 ABCC4 ABCC5 SULT2A1-4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC1 ABCB1 CYP2E1 CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABCG2 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation BCKDHA BCKDHB MMUT PCCA PCCB DBT SDS DLD METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) FPGS GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS ALDH1L1 SLC46A1 MTFMT MTHFD1L MTHFD1 MTHFD2 MTHFR CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 ADH1C;ADH1B;ADH1A CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine AARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCB1 ABCC2 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PLA2G2A-1 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5PB ATP5MC2 ATP5F1C ATP5F1D CYCS-1 ATP5F1A SDHC ATP5F1B SDHD GPD2 SDHA UQCRC1 SDHB GAPDH-1 SLC25A4 SLC37A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism VKORC1 GGCX NQO1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway CYP1A2 SCN10A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SCN1B 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency LIPA CYP27A1 CYP39A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism BTD SPCS1 HLCS ACACB CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism GALE AKR1B1 GLB1 GAA LCT GLA UGP2 B4GALT1 GALT PGM1 HK1 G6PC1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway ALDH3A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A CYP2E1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism HADH ECHS1 HMGCL ACAT1 ACADS OXCT1-1 ACSM1 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 GSR CAD GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway LSS SQLE ACAT1 FDPS IDI1 PMVK MVK MVD FDFT1 HMGCS1-1 HMGCR BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDIPT PGS1 JMJD7-PLA2G4B;PLA2G4B CDS1 GPAM DGKA PTPMT1 CHAT GPD1 GDE1 LYPLA1-1 CRLS1 AGPAT1 PLD2 PTDSS2 PTDSS1 PLA2G2D PCYT1A CHKA PISD PLA2G15 PHOSPHO1 PEMT PLPP1 GPD2 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C6 C7 C9 C3-1 CFP C8A CFB CFD C5 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) AKR1B1 DHFR2;DHFR PTS CBR1-1 GCHFR QDPR GCH1 SPR CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides TYRP1 CAT SOD2 SOD3 SOD1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway CES1 PDIA2 UGT1A1;UGT1A6 ABCG2 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 TOP1 ABCC2 CES2 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway AGTR1 ACE REN AGT GNG2 GNAQ GNB1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 ABCC1 ABCB1 ABCC2 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway RAF1 HRAS STAT5A MAPK3 STAT5B INS;INS-IGF2 IRS1 INSR SLC2A4 GHR SOCS1 RPS6KA1 GRB2 PTPN6 PLCG1 SOS1 JAK2 SHC1-1 PRKCA MAP2K2;MAP2K1 MAPK1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct ATP1A1 SLC14A2 SLC4A1 SCNN1G AQP2 ATP1B3-1 AQP3 ATP6V1B1 SCNN1D REN SCNN1B SCNN1A FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ATP1A4 ATP1A3 CA1 ATP1A2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD2 GAPDH-1 GPD1 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia AKR1B1 DHFR2;DHFR PTS CBR1-1 GCHFR QDPR GCH1 SPR 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PDHA1 PCK1 AKR1B1 PC DLD DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine VARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 PAK1 CASP7 CASP8 CASP6 CASP10 CASP3 LMNA ARHGDIB FADD PAK2 SPTAN1 MAP3K7 DFFB MAP2K4 DAXX JUN DFFA PARP1 RIPK2 CFLAR PTPN13 FAS MAP3K1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway TUBB1 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC1 ABCB1 ABCC2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC MPC1 AGXT GPT AARS2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency AKR1B1 DHFR2;DHFR PTS CBR1-1 GCHFR QDPR GCH1 SPR GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway SLC22A6 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 GPX1 DNAJB11 PTGIS ERP29 CYP2J2-1 PPIB SDF2L1 EPHX2 ALOX15 HSPA5 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 HYOU1 CBR1-1 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SLC22A8 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC4A4 SLC9A1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 SLC38A4 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 AQP1 CA1 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway RAF1 HRAS STAT5A EPO MAPK3 FOS ELK1 EPOR MAPK8 GRB2 PTPN6 PLCG1 SOS1 JAK2 SHC1-1 JUN MAP2K2;MAP2K1 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development SRF GATA4 NKX2-5 HOPX GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease B4GALT6 ENPP7 PLPP1 ARSA GAL3ST1 SGMS1 GLB1 CERK SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell GLP1R CACNA1A RAB3A SLC2A2 ITPR3 CAMKK1 RIMS2 ADCY10 VAMP2 RAPGEF4 GNG2 GNAQ GNB1 PLCB1 ABCC8 CACNA2D2 PRKCA CHRM3 CACNB1 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 HTR6 GNB1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 OPRM1 CYP2C9;CYP2C19 GRIN1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GRIN3A GRIN2A PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism MAT2B SCLY GGT1 SEPHS2 PAPSS1 MAT2A CBS;CBSL CTH AHCY MARS1 SLC39A8 METTL6 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL UGP2 HK2 GCK PGM2L1 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 ADCY2 PRKACB-1 GNGT1 GNAS-1 PTGDR GNB1 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria FARSA FAH GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD TAT PAH FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling ITPR1 AKT1 ADCY1 PLCB1 LPAR4 SRF GNAS-1 GNG2 ROCK1 GNB1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP21A2 CYP11B1;CYP11B2 CYP11A1 CYP17A1 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency PEX11G CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 SLC25A20 CROT CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease B4GALT6 ENPP7 PLPP1 ARSA GAL3ST1 SGMS1 GLB1 CERK SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway FAH GSTZ1 DCT ACSS2 ALDH2 ACSS1 ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A CAT HGD MAOA HAAO MIF DBH TYR CYP2E1 COMT ALDH1B1 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC MPC1 AGXT GPT AARS2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III GALE UXS1 GALK1 UGP2 GCK GALT PGM1 UGDH PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway AKT1 PLCB1 VAV1 PIK3CG PIK3R6 PRKCA PLCG1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT1 NPR1 NAMPT NMNAT3 RORA NMNAT2 CLOCK PPARGC1A SIRT1 NQO1 NADK CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA HTR7 GNAS-1 GNB1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway PTGS2-2 SLC22A6 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC22A8 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A2 SLC6A4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B4 ATP1B1 CACNB1 PRKAR1B UQCR11 DLG1 PRKAR1A PRKAR2B KCNQ1 PRKAR2A KCNK1 MCU SLC9A1 ALG10;ALG10B SNTB1 SNTB2 PRKACB-1 GNAS-1 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 CYP2D6;LOC107987479;LOC107987478-1 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway CHRNB2 CHRNA3 CYP2A13;CYP2A6;CYP2A7-1 FMO3 CYP2B6 AOX1 CHRNA4 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis TMLHE SETD7 BBOX1 ALDH9A1 SHMT1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency AKR1B1 ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 GSR CAD GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL UGP2 HK2 GCK PGM2L1 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I HADH ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway NME1 NME2 AK1 AK2 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP21A2 CYP11B1;CYP11B2 CYP11A1 CYP17A1 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism CTNS CDO1 CARS1 GOT1-1 CTH GCLC LDHA GCLM MPST MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway FOS ELK1 SRF GRB2 PLCG1 PRKCB SOS1 SHC1-1 STAT6 JAK1 STAT1 EGF STAT2 STAT3 PRKCA RASA1 CSNK2A1;CSNK2A3 MAP2K2;MAP2K1 RAF1 HRAS MAPK3 MAPK8 MAP2K4 JUN EGFR MAP3K1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism FPGS GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS ALDH1L1 SLC46A1 MTFMT MTHFD1L MTHFD1 MTHFD2 MTHFR FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS;CBSL CTH VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism AOX1 PDXK PNPO ALPL PDXP NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 MARS1 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway CES1 CDA SLC28A1 TYMP TYMS DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism RFK ENPP1 ACP1 TYR FLAD1 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids HADH ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 ACADL ACADS ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis AGPAT1 GNPAT AGPS CEPT1 PLPP1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX PAPSS2 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PTGS1 ADH1C;ADH1B;ADH1A ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway NME1 NME2 AK1 AK2 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation ATP1B3-1 ATP1A1 SLC2A2 GCK FXYD2;FXYD6-FXYD2 TREH ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PDHA1 PCK1 AKR1B1 PC DLD HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AOX1 MAOA MAOB SLC6A4 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria HADH ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle SLC2A2 SLC2A4 GLUD1;GLUD2 GPT SLC38A4 GPT2 SLC1A4 SLC25A22 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway DCK NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 RRM1 CMPK1 RRM2-1 CTPS1 TYMS WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect PGK1 FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT GPI IDH3A G6PD SLC1A5 TALDO1 PDHA1 PGD IDH3G RPIA IDH1 PFKL PGAM2 ENO1 PGLS SDHC SDHD HK2 SDHA TKT GAPDH-1 SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 ACO1 SUCLG1 ACO2 DLD PKLR SLC2A2 MDH1 LDHA SLC16A1 PKM ALDOB ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) DHCR7 LBR EBP NSDHL SC5D CYP51A1 DHCR24 MSMO1 HSD17B7 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway TYK2 JAK1 STAT3 MTOR MAPK1 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway CES1 OPRM1 BCHE CES2 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway CHUK AKT1 RAF1 RALGDS RALBP1-1 HRAS MAPK3 ELK1 RAC1 CYCS-1 VAV3 BAD SMAD4 APAF1 FOXO4 RALA-1 PLD1 RHOA CDC42 CASP9 MAP2K2;MAP2K1 PIK3CA SMAD2;SMAD3 BCL2L1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis AGTR1 HSD3B1;HSD3B2 CYP21A2 CYP11B1;CYP11B2 GNG2 CYP11A1 GNAQ GNB1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCG2 ABCB1 EGFR NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria CTNS CDO1 CARS1 GOT1-1 CTH GCLC LDHA GCLM MPST ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling ITPR1 AKT1 ADCY1 PLCB1 LPAR5 SRF GNAS-1 GNG2 ROCK1 GNB1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling AKT1 RAF1 HRAS PIK3CG INS;INS-IGF2 IRS1 PIK3R6 INSR PDPK1 SLC2A4 FOXO1-1 MAPK8 IRS2 GRB2 SOS1 SHC1-1 MAP2K2;MAP2K1 MAPK1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PDHA1 PCK1 AKR1B1 PC DLD PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine LARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked PEX11G CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 SLC25A20 CROT ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) LIPA CYP27A1 CYP39A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System ADCY2 PRKACB-1 GNAS-1 DRD1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway EPHX1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway RB1 PCNA GADD45B CCNB1 CCND1 CCNE1 CDK4 CDK2 BCL2 CDKN1A CDK1 E2F1 BAX APAF1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway CFD C5 C6 C7 C9 C3-1 C8A C1QB CFB C1S C1R C2 MBL2-1 SERPING1 MASP2 MASP1 LOC110384692;C4A;C4B_2;C4B C1QC MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMD4 PSMB2 PSMB3 UBD PSMB1 UBB;UBC UBE2E1 PSMC2-1 PSMA2-1 PSMA5 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 STUB1 UBA1 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura AKR1B1 ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 XDH CYP2E1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 CYP2D6;LOC107987479;LOC107987478-1 HTR1A ATP1A1 OPRM1 CACNA1A UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial HADH ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP21A2 CYP11B1;CYP11B2 CYP11A1 CYP17A1 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary GMPPB GMDS FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway FOS ELK1 CD79B CD79A PPP3CA PPP3CB PPP3CC GRB2 BLNK RAC1 PLCG1 LYN SYK PRKCB SOS1 NFATC3 NFATC2 SHC1-1 NFATC1 CALM3;CALM1 NFATC4 BTK ORAI1 PRKCA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 MAPK8 JUN MAP3K1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling ITPR1 AKT1 ADCY1 PLCB1 LPAR1 SRF GNG2 ROCK1 GNB1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 ACAT1 OXCT1-1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis CEPT1 PCYT1A CHKA PCYT2 PISD PEMT HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis TOP2A CAD DFFA CASP7 GZMH;GZMB-1 ENDOG HMGB2 CASP3 HMGB1-1 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA PRKACB-1 GNGT1 PRKACA-1 ADCY10 GNAS-1 PRKAR1B PRKAR1A PRKAR2B PRKAR2A GNB1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome LIPA CYP27A1 CYP39A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A KARS1 RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL UGP2 HK2 GCK PGM2L1 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C6 C7 C9 C3-1 C8A C1QB C1S C1R C2 LOC110384692;C4A;C4B_2;C4B C5 C1QC GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism QPRT NADSYN1 ENPP1 BST1 NNT NT5C2 NMRK1 NUDT12 NAMPT NMNAT2 NADK AOX1 PNP-1 NNMT SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway PTGS2-2 TOP2B PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL STAT5A SLC22A1 GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 ABCB1 CRK BCL2L1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease CMAS GFPT1 HEXA UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism TPH1 ASMT KMO WARS1 INMT ALDH2 WARS2 ACMSD AANAT TDO2 KYNU AFMID CYP1A1 IDO1 AADAT DDC CAT HAAO LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation CHUK MDH1 NFKB1 ACACA NFKBIA IKBKB TRAF6 IKBKG ME1 SLC25A1 SDHC LY96 SDHD SDHA TIRAP SDHB ACLY CS CD14 TLR4 MYD88 RELA HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP21A2 CYP11B1;CYP11B2 CYP11A1 CYP17A1 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis ADCY2 PRKACB-1 GNGT1 FSHR GNAS-1 AVPR2 GNB1 COAGULATION%SMPDB%SMP0000586 Coagulation VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ACSS2 ADH1C;ADH1B;ADH1A CAT ALDH2 CYP2E1 ACSS1 ALDH1B1 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency AKR1B1 ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine GARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia GALE AKR1B1 GLB1 GAA LCT GLA UGP2 B4GALT1 GALT PGM1 HK1 G6PC1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) DHCR7 LBR EBP NSDHL SC5D CYP51A1 DHCR24 MSMO1 HSD17B7 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) FARSA FAH GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD TAT PAH VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway TUBB1 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC1 ABCB1 ABCC2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency AKR1B1 DHFR2;DHFR PTS CBR1-1 GCHFR QDPR GCH1 SPR HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP21A2 CYP11B1;CYP11B2 CYP11A1 CYP17A1 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT1 NAMPT TP53 NMNAT3 NMNAT2 SIRT1 NQO1 AIFM2 NADK CD38 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway AGTR1 ACE REN AGT GNG2 GNAQ GNB1 GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer FH DLST PDHB DHTKD1 MPC1 IDH3B GOT2-1 DLAT IDH3A SLC1A4 SLC1A5 PDHA1 IDH3G IDH2 SLC7A7 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 SUCLG1 ACO2 DLD LDHA ME1 SLC16A1 ACLY SLC38A5 MYCBP-1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle ATP1B3-1 ATP1A1 REN FXYD2;FXYD6-FXYD2 CLCNKA;CLCNKB ATP1B2 ATP1B1 SLC12A6 ATP1A4 ATP1A3 SLC12A1 ATP1A2 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway FPGS GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS ALDH1L1 SLC46A1 MTFMT MTHFD1L MTHFD1 MTHFD2 MTHFR GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL UGP2 HK2 GCK PGM2L1 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline EPRS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway PXN RAF1 CXCR4 HRAS PIK3C2G MAPK3 PTK2 GNAI1 NFKB1 GNGT1 CXCL12 NFKBIA PTK2B BCAR1 PLCG1 GNAQ GNB1 MAP2K2;MAP2K1 MAPK1 CRK ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway AGTR1 ACE REN AGT DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 AOX1 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 CYP2D6;LOC107987479;LOC107987478-1 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A MAOB ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 MAOA ATP1B2 ATP1B1 CACNB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 GSR CAD GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II LIPA CYP27A1 CYP39A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway AGTR1 ACE REN AGT GNG2 GNAQ GNB1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC MPC1 AGXT GPT AARS2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling CHUK MAPK14 NFKB1 NFKBIA IKBKB MAPK8 MAP2K3 ATF1 MAP4K2 CRADD IKBKG TRADD TRAF2 TANK TNF CASP2 RIPK1 MAP2K7 MAP2K6 MAP2K4 JUN MAP3K1 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 ABCD2 HACL1 SLC27A2 PHYH-4 ABCD1 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL UGP2 HK2 GCK PGM2L1 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids HADH CPT1A ECHS1 HADHB-1 ACAA2 ACSL1 HADHA CPT2 ACADL SLC25A20 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures HADH ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway CHRNA3 CYP2A13;CYP2A6;CYP2A7-1 PCSK2 CYP2B6 AOX1 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 FMO3 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy B4GALT6 ENPP7 PLPP1 ARSA GAL3ST1 SGMS1 GLB1 CERK SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism CNDP1 HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 HDC AOC1 PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine IARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle MDH2 SLC25A11 GOT2-1 SLC25A12 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) DCTD NT5C2 RRM2B CDA DUT CANT1 DPYS NME6 CAD AK3 UPB1 RRM2-1 UCKL1 TYMP DHODH ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway SLC44A2 MAT2B SHMT2 MTR-1 GNMT BHMT MAT2A CHDH SARDH ALDH7A1 SHMT1 DMGDH SLC44A1 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C6 C7 C9 C3-1 C8A C2 MBL2-1 MASP2 MASP1 LOC110384692;C4A;C4B_2;C4B C5 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway CES1 CDA SLC28A1 TYMP TYMS L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria MDH1 ACLY PDHB PC MPC1 SLC25A11 ME1 PDHA1 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P2RY12 ABCB1 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 GSR CAD GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 ADRA1A KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HSD17B10 ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency DCTD NT5C2 RRM2B CDA DUT CANT1 DPYS NME6 CAD AK3 UPB1 RRM2-1 UCKL1 TYMP DHODH ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells AKT1 INPP5D MAPK14 MAP2K3 GRB2 RAC1 PLCG1 LYN SYK SOS1 TNF MAP2K7 MAP2K6 BTK GAB2 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 HRAS CSF2 MAPK8 NRAS FCER1A FYN PDK1 FCER1G IL13 PLA2G4A IL4 IL3 IL5 LCP2 KRAS MS4A2 VAV3 MAP2K4 LAT PIK3R1 PIK3CA DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP21A2 CYP11B1;CYP11B2 CYP11A1 CYP17A1 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 L2HGDH ACO1 SUCLG1 ACO2 DLD PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form BTD SPCS1 HLCS ACACB LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia IL4I1 ABAT ASS1 ADSL ASNS ASL ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP21A2 CYP11B1;CYP11B2 CYP11A1 CYP17A1 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism CDO1 GAD1 CSAD ADO GGT6 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III LIPA CYP27A1 CYP39A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D-1 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation RB1 TP53 BTG2 BTG1 CHAF1A HOXB9 PRMT1 FGF1 CCND1 NGF TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway INS;INS-IGF2 ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium GUCY1A1 NOS3 TRPC3 TRPC4 TRPV4 KCNQ2 KCNQ3 PRKG2 KCNQ4 KCNQ5 ADCY10 PRKG1 GUCY1A2 GUCY1B1 TRPC7 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway AGTR1 ACE REN AGT GNG2 GNAQ GNB1 ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway DCK NME1 PGK1 NT5C SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SLC22A1 SLC22A2 ABCC4 PCYT1A ABCG2 SLC22A3 CHPT1 ABCC3 PCYT2 CMPK1 ABCC1 ABCB1 ABCC2 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A2 SLC6A4 ABCB1 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) GALE UXS1 GALK1 UGP2 GCK GALT PGM1 UGDH ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway CYP2C9;CYP2C19 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway PTGS2-2 TOP2B PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 ABCC3 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 GSR CAD GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification SLC2A4 SLC2A1 PNP-1 AS3MT GSTO1 AQP9 LOC100509620;LOC112267859;AQP7 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) FARSA FAH GSTZ1 YARS1 IL4I1 HPD FARSB GOT1-1 HGD TAT PAH HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine RPL4 SARS1 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling ITPR1 AKT1 LPAR2 ADCY1 PLCB1 SRF GNG2 ROCK1 GNB1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 NR1H4 SLC10A2 FGFR4 FGFR3 FGFR2 FGFR1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SNTB1 ABCC8 SNTB2 CACNA1A SLC2A2 CACNA2D2 GCG SCN5A SNTA1 CACNB1 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria GMPPB GMDS FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids PEX11G CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 ABCD1 SLC25A20 CROT INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin ADCY2 PRKACB-1 GNGT1 PTGIR MYL3 GNAS-1 MYLK GNB1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation HADH ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 CHUK MAPK14 NFKB1 NFKBIA IKBKB TRAF6 IKBKG ECSIT RELA IRAK1 TLR1 TOLLIP TLR9 TAB3 TLR8 TLR7 TAB2 TAB1 TLR6 MAPK8 TLR5 TLR3 TLR2 MAP3K7 LY96 MAP2K4 TIRAP CD14 TLR4 MYD88 MAP3K1 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway CES1 PDIA2 UGT1A1;UGT1A6 ABCG2 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 TOP1 ABCC2 CES2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis PANK1 ENPP1 VNN1 PPCS PPCDC COASY METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP21A2 CYP11B1;CYP11B2 CYP11A1 CYP17A1 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine AKT1 CHUK ELK1 PRKACB-1 GNGT1 NFKB1 PDPK1 NFKBIA CREB1 IKBKB RPS6KA1 GNAS-1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS MAPK8 PAK1 ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 MAPK11 ADORA2A JUN RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA MAP3K1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor ITPR1 PLCB1 PRKCA GNAQ HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary FPGS GGH DHFR2;DHFR FTCD ST20-MTHFS;MTHFS ALDH1L1 SLC46A1 MTFMT MTHFD1L MTHFD1 MTHFD2 MTHFR SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HSD17B10 ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 TARS1 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis AKR1B1 DHFR2;DHFR PTS CBR1-1 GCHFR QDPR GCH1 SPR NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism GALE UXS1 GALK1 UGP2 GCK GALT PGM1 UGDH PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway RALBP1-1 ABCC3 CDKN1A TUBB1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TP53 ABCC1 ABCB1 ABCC2 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 ADRA1A KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) FH MDH1 DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia CNDP1 HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 HDC AOC1 PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PDE4D-1 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids HADH ECHS1 HADHB-1 ACAA2 HADHA ACSM1 ACADM SLC25A20 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX PAPSS2 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism HSD11B1 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 CYP11B1;CYP11B2 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 SRD5A1 HSD17B3 AKR1D1 CYP19A1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 PDHA1 EGLN2 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 SLC25A10 ACO1 SUCLG1 ACO2 DLD BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 VEGFA KDR NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway HSPA5 HYOU1 OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PTDSS1 CEPT1 CHKA PCYT2 PISD METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A YARS1 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism FIG4 IPPK PIKFYVE MIOX ISYNA1 INPP1 ITPK1 IPMK PI4KA INPP4A MINPP1 IMPA1 PIK3C3 ITPKA INPP5J PLCD3 VAC14 BECN1 PIK3R4 AMBRA1 PIK3CA PTPMT1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway HSD17B10 HADHB-1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ACADSB HADHA CYP2B6 ACSM1 IVD EHHADH-1 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid DARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance ATP1B3-1 ATP1A1 LCT SLC2A2 FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SNTB1 SNTB2 SCN5A SNTA1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 ALDH1A1 ABCC10 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway ERBB3 ERBB4 NRG2 PSEN1 PRKCA ADAM17 EGFR RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway RALBP1-1 PAK1 PCNA RAC1 CCND1 CDKN1A CAP1 VAV3 PDGFRA WASF1-1 LIMK1 CCND3 CDK5 PLD1 ACTB-1 MYLK RPS6KB1 MYL2 CFL1 ARFIP2 PPP1R12B MAP3K1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS;CBSL CTH KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) B4GALT6 ENPP7 PLPP1 ARSA GAL3ST1 SGMS1 GLB1 CERK SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway CHUK NFKB1 NFKBIA IKBKB TRAF6 IKBKG TRADD TNF RIPK1 RELA IRAK1 CAMKK2 IL1R1 NCOA3 TNFRSF1B TNFRSF1A IL1A TAB1 MAP3K14 CAMKK1 UBB;UBC FADD MAP3K7 TLR4 MYD88 MAP3K1 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB-1 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CYP2B6 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 CYP2D6;LOC107987479;LOC107987478-1 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CCKBR HRH2 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL UGP2 HK2 GCK PGM2L1 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS2 ELOVL4 ELOVL5 FADS1 JMJD7-PLA2G4B;PLA2G4B OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease B4GALT6 ENPP7 PLPP1 ARSA GAL3ST1 SGMS1 GLB1 CERK SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism ALAS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 GUSB ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism MAT2B MTR-1 BHMT MAT2A CHDH ALDH7A1 PEMT AHCY BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency BTD SPCS1 HLCS ACACB FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A CARS1 RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL STAT5A GRB2 SOS1 JAK2 CDKN1B BAD MDM2-2 TP53 GAB2 CBL MTOR CRKL RPS6KB1 PIK3R1 MYC SKP2 CRK BCL2L1 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC MPC1 AGXT GPT AARS2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway CES1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IMPDH1 ABCG2 IMPDH2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCB1 ABCC2 CES2 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism RPE65 DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 RETSAT ADH1C;ADH1B;ADH1A RDH8 RDH12 AWAT1 RDH11 LRAT BCO1 DGAT1 DHRS3 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 CYP2D6;LOC107987479;LOC107987478-1 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency FAH GSTZ1 DCT ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P2RY12 ABCB1 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis NOX4 CYBA DUOX2 SLC5A5 DUOX1 TPO TG NOX3 CYBB HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine AKT1 CHUK ELK1 PRKACB-1 GNGT1 NFKB1 PDPK1 NFKBIA CREB1 IKBKB RPS6KA1 GNAS-1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS ADCY2 MAPK8 PAK1 ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 ADORA2B MAPK11 JUN RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA MAP3K1 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome PGK1 PFKM PKLR SLC2A2 GPI PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 GALM-2 G6PC1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell SST ABCC8 CACNA1A SLC2A2 CACNA2D2 CACNB1 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling AKT1 PIK3CG INS;INS-IGF2 IRS1 PIK3R6 INSR IRS2 SLC7A5 TSC2 TSC1 RHEB EIF4EBP1 MTOR EIF4E RPS6KB1 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency AKR1B1 DHFR2;DHFR PTS CBR1-1 GCHFR QDPR GCH1 SPR SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 ACAT1 OXCT1-1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) LIPA CYP27A1 CYP39A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling P4HA3 TLR4 IL1B NLRP3 HIF1A SIRT3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PDHA1 PCK1 AKR1B1 PC DLD REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway AGTR1 ACE REN AGT GNG2 GNAQ GNB1 TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 OPRK1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 GNB1 HTR4 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A1 HYOU1 HSD17B1 COMT MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway SRC CALML6 ADCY1 LHB CAMK2A ELK1 GNA11 MAPK14 GNRHR MAP3K2 EGR1 CGA MAP2K3 MMP2 FSHB ACTN4 GNAS-1 GRB2 MMP14 LRRC7 PRKCB GNRH1 SOS1 HBEGF ATF4 ITPR1 PLCB1 MAP2K7 PRKCA CACNA1D CACNA1F JMJD7-PLA2G4B;PLA2G4B MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS CACNA1C PRKACA-1 MAPK8 JUN CACNA2D2 PLD1 CDC42 CACNB1 EGFR MAP3K1 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) ECHS1 ACAT1 ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 CHUK FOS ELK1 MAPK14 NFKB1 NFKBIA IKBKB MAP2K3 TRAF6 IKBKG EIF2AK2 PPARA MAP2K6 ECSIT RELA IRAK1 TOLLIP TLR9 TLR7 TAB2 TAB1 MAPK8 TLR3 TLR2 MAP3K7 LY96 MAP2K4 TIRAP JUN CD14 TLR4 MYD88 MAP3K1 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis AGPAT5-1 CRLS1 CDS2 PGS1 GPAM PTPMT1 GPD1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway FOS ELK1 NFKB1 NFKBIA PPP3CA PPP3CB PPP3CC GRB2 RAC1 PLCG1 PRKCB SOS1 NFATC3 NFATC2 SHC1-1 NFATC1 CALM3;CALM1 CD3G NFATC4 CD3E CD3D RASGRP1 ZAP70 LCK PTPN7 PRKCA CD247 RELA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 PIK3CG MAPK8 FYN UBB;UBC MAP2K4 LAT JUN PIK3R1 PIK3CA MAP3K1 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway ABCC4 SLC29A1 ABCC5 SLC28A3 XDH TPMT ADK PPAT RAC1 SLC28A2 SLC29A2 HPRT1 IMPDH1 AOX1 GMPS FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNA1C CACNA2D2 CACNB1 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PTK2B PRKCA P2RY2 PLCG1 PRKCB MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type MAT2B SRM IL4I1 MTAP BHMT MAT2A CBS;CBSL CTH CHDH MSRB2 MSRB3 DNMT1 SHMT1 MARS1 AMD1 MTHFR MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) DCTD NT5C2 RRM2B CDA DUT CANT1 DPYS NME6 CAD AK3 UPB1 RRM2-1 UCKL1 TYMP DHODH ITPA GDA DPYD CTPS1 CMPK2 TYMS TK1 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway ITPR1 CALM3;CALM1 NOS1 PRKACB-1 GRIN1 GRIN3A PPP3CA XDH PRKCA ALDH2 DLG4 GRIN2A METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia AOX1 PDXK PNPO ALPL PDXP PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency ABAT GFPT1 PPAT GOT2-1 GPT ALDH4A1 CPS1 NAGK GLUL GNPNAT1 GSS GAD1 GSR CAD GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome FIG4 INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP4K2A PIP5K1A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD PIK3R1 AMBRA1 PIK3C2A EGFR ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP21A2 CYP11B1;CYP11B2 CYP11A1 CYP17A1 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 CYP2D6;LOC107987479;LOC107987478-1 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP21A2 CYP11B1;CYP11B2 CYP11A1 CYP17A1 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic CTNS CDO1 CARS1 GOT1-1 CTH GCLC LDHA GCLM MPST BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) NR1H4 SLC10A2 ABCC4 GPBAR1 SLCO1A2 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids CRAT PEX13 PEX14 ACSL1 CPT2 ABCD2 HACL1 ALDH2 PHYH-4 ABCD1 SLC25A20 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome SLC35A2 UGP2 CANT1 B4GALT1 GALT CMPK1 SLC2A1 NME2 LALBA G6PC1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 ADRA1A SLC6A2 SLC6A3 ATP1A4 SLC6A4 ATP1A3 GRIN2A DRD1 ATP1A2 SCN1B CHRNB2 KCND2 HTR1A ATP1A1 OPRM1 CACNA1A GRIN1 POMC SCN10A GRIN3A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway PDIA2 UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PDHA1 PCK1 AKR1B1 PC DLD TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism B4GALT6 ENPP7 PLPP1 ARSA GAL3ST1 SGMS1 GLB1 CERK SPHK2 GBA GLA SGPP2 GALC NEU3 UGCG UGT8 ACER1 SGPL1 SPTLC1 ACER3 KDSR DEGS2 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) HSD11B1 HSD11B2 HSD3B1;HSD3B2 AKR1D1 CYP21A2 CYP11B1;CYP11B2 CYP11A1 CYP17A1 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency ALAS1 SHMT2 GLYCTK GCAT GNMT GARS1 GAMT SRR SARS1 CTH PSAT1 SARDH PHGDH ALDH2 AGXT SDS PSPH GLDC GATM AMT MAOA SHMT1 DMGDH DLD GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production PRKACB-1 GNGT1 POMC GNAS-1 MC2R GNB1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling LPAR6 AKT1 ADCY1 SRF GNAS-1 GNG2 ROCK1 GNB1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation GMPPB GMDS FCSK FPGT PHPT1 GFUS HK1 TPI1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CPS1 GATM DAO EPRS1 P4HA3 ASL NOS1 CKB GOT1-1 PRODH;LOC102724788 OTC GLUD1;GLUD2 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis LIPA CYP27A1 CYP39A1 CH25H AMACR ACOX2 SCP2 SLC27A5 HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine HARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SLC6A2 SLC6A4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin LHCGR LHB ADCY2 PRKACB-1 GNGT1 CREB1 CGA PPP1CA GNAS-1 GNB1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation ATP1B3-1 ATP1A1 LCT SLC2A2 FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1B1 ATP1A4 ATP1A3 ATP1A2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency SLC2A2 MPC1 LDHA GPI TPI1 PCK1 MDH2 PANK1 PGAM1 PGAM2 ENO1 BPGM ALDOA HK2 GAPDH-1 FBP1 SLC37A4 PGM1 PC SLC25A11 GALM-2 G6PC1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism AKR1B1 ALDH3A1 GLYCTK AGPAT1 GPD2 LIPC LPL PLPP2 GPAM PLPP1 GPD1 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GPI MGAM GBE1 PYGL UGP2 HK2 GCK PGM2L1 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis LPIN1 AGPAT1 GPAM DGAT1 GPD1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS;CBSL CTH HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway AGTR1 ACE REN AGT GNG2 GNAQ GNB1 CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 UPB1 ALDH2 DPYD GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation ALDH8A1 DLST DHTKD1 ACMSD DLD BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 WARS1 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism INPP4B IPPK ISYNA1 NUDT3 INPP1 PPIP5K1 ITPK1 IP6K1 IPMK INPP4A MINPP1 IMPA1 ITPKA INPP5J ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway SERPINC1 VKORC1 FGB FGA F10 F12 F11 FGG F13A1 PLG PLAT F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II HADH ECHS1 DLST ACAT1 DHTKD1 GCDH SLC25A2 AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action ITPR1 PLCB1 NFKB1 HRH1 GNG2 PRKCB GNAQ GNB1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency SULT2B1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 STS SRD5A1 HSD17B1 HSD17B3 HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule ATP1A1 SLC8A1 TRPV5 CLCNKA;CLCNKB SLC12A3 AQP2 ATP1B3-1 AQP3 REN FXYD2;FXYD6-FXYD2 ATP1B2 ATP4B ATP1B1 ATP4A ATP1A4 ATP1A3 ATP1A2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria ARG1 GOT2-1 ASS1 GPT SLC1A4 SLC25A15 CPS1 SLC1A5 SLC25A12 ASL OTC GLS2 GLUD1;GLUD2 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway KCNK1 ALG10;ALG10B SNTB1 SNTB2 CHRM2 HCN4 RYR2 KCNE2 KCNE1;KCNE1B ATP1A4 ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 CACNA1C ATP1A1 SLC8A1 CACNA1H CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 KCND3 ATP1B3-1 ABCC8 KCNIP2 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation CHUK NOS3 MAPK3 NFKB1 CREB1 IKBKB SUCNR1 IKBKG PLCB1 MAPK11 PTGS1 PRKCA MAPK1 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 ENTPD8 HPRT1 AMPD1 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 RRM2-1 PNP-1 GART ITPA ADA D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway PRF1 ARHGAP5 CASP8 ARHGAP32 CASP10 CASP1 CASP3 ARHGDIB CYCS-1 JUN APAF1 PARP1 GZMH;GZMB-1 CASP9 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria GSS GSR GCLC CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway GGT1 PTGES PTGS2-2 GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine NARS1 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPL14 RPS3 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine ADCY2 PRKACB-1 GNGT1 CREB1 PPP1CA GNAS-1 HRH2 GNB1 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis LIPA LSS ACAT2 TM7SF2 SQLE EBP NSDHL SOAT1 PMVK SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling ITPR1 AKT1 ADCY1 PLCB1 GNAS-1 GNG2 LPAR3 GNB1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate FH DLST PDHB DHTKD1 MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260810%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression MAP2K3 PRKAA1 PIK3CD PIK3R3 TSC2 TSC1 PIK3R2 PIK3CB PIK3R1 MTOR MAP2K2;MAP2K1 PIK3CA MKNK1 MKNK2 EIF4EBP1 PBK MAPK1 AKT1 RAF1 EIF4E MAP3K11 MAP2K6 MAP3K5 MAPK3 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260810%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly RBBP4 ATRX H4-16 H4C1 SMIM40 H4C6 HIRA CHAF1B H2BC15;H2BC3;H2BC11;H2BC12 DAXX CHAF1A INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260810%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PIK3CD PIK3R3 TSC2 TSC1 PIK3R2 PIK3CB PIK3R1 MTOR PIK3CA MAPK1 AKT1 TRIO ROCK1 PKN3 YAP1-1 AKT2 AKT3 TEAD1 TEAD2 TEAD3 TEAD4 RHOA PTK2 MOB1A;MOB1B LATS1 PLCB3 PLCB4 LATS2 GNAQ PKN2 PKN1 PLCB1 PLCB2 METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260810%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases MTTP APOA2 LPL LCAT PCSK9 APOA1 LIPC APOC2 LIPG APOE LDLRAP1 APOB LDLR ABCA1 CETP SCARB1 ANXA2 GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP4159%HOMO SAPIENS GABA receptor signaling GABRB3 GABRB2 GABRB1 ABAT AP2A1 SLC6A1 AP2A2 GPHN GABRG3;GABRG2 AP2S1 GABRE GABRD AP2M1 GABRQ GABRA2 GABRA1 GABRP GABBR2 GABBR1 GABRA6 SLC32A1 GABRA5 GAD1 GABRA4 GABRA3 GAD2 SLC6A11 AP2B1 GABRG1 ALDH9A1 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260810%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors ITGB6 TNXB ITGB5 LAMB2 LAMA4 SDC2 ITGA1 FN1 LAMC1 THBS2 THBS1 COL3A1 COL1A2 COL4A2 COL5A1 COL4A1 COL5A3 COL6A2 ITGA11 COL6A1 COL5A2 COL6A3 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260810%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HDAC4 HDAC5 ATF2 ADH1C;ADH1B;ADH1A HDAC2 ACSS2 HDAC3 AHCY HDAC10 HDAC1 EHMT2 MTR-1 HDAC8 TYMS HDAC9 HDAC6 HDAC7 ALDH2 SLC19A1 MTHFR ELP3 MAT1A DHFR2;DHFR ALDH1A3 KAT2B ALDH1A2 HAT1 ALDH1A1 CYP2E1 NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260810%WP4747%HOMO SAPIENS Netrin UNC5B signaling MAP2K2;MAP2K1 PIK3CA MAPK1 AKT1 RAF1 MAPK3 ROBO4 ITGB4 TNF ICAM1 CDH5 PPP2R1B CASP3 KDR CCN2 RAC1 NEO1 IL10 YAP1-1 ARHGEF12 UNC5B PRKCA CIP2A RGMA IL1A RHOA DCSTAMP TP53 PTK2 CCL13;CCL2 DAPK1-1 SRC AGAP2 NTN4 NTN1 RLF NTN3 PTPA INPP5D PTK2B FYN PLEKHH1 JUN VCAM1 PTPN11 MAPK14 SELE PPP1CA COL1A1 ALPL MYF5 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260810%WP2795%HOMO SAPIENS Cardiac hypertrophic response HDAC4 HDAC5 MAP2K3 MTOR MAP2K2;MAP2K1 HDAC9 HDAC7 MAPK1 AKT1 RAF1 MAP2K6 MAPK3 TNF RAC1 AKT2 PRKCA MAPK14 GSK3B TGFBR1-1 FGF2 PLA2G2A-1 IKBKB PPP3CA NPPA IKBKG IKBKE MAP3K7 PRKG1 MEF2A MAP4K1 MAP2K4 CHUK PDPK1 NRG1 TNFRSF1A PRKD1 CAMK2D MAPK8 MAPK7 MAP2K7 MAP2K5 LOC118142757;GUCA1A TGFB1 MAP3K1 EGF NFATC2 IGF1 NFKB1 CDK9 CDK7 CALM1 MAP3K14 FGFR2 IL19 SIGNALING%WIKIPATHWAYS_20260810%WP5422%HOMO SAPIENS IL19 signaling MAPK14 COL1A1 MAPK1 AKT1 TNFRSF1A MAPK3 MAPK8 TNF TGFB1 NFKB1 RAC1 CCL11 IL20RA CXCR4 IL20RB CCNB1 SOCS1 STAT6 JAK1 SOCS5 IL4R STAT1 MMP1 STAT3 IL19 MUC5AC ACTA2 IL4 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260810%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids CHKB PCYT1A DGAT1 PLA2G1B PLD1 DGKZ CRLS1 PISD AGPAT4 PTDSS2 PTDSS1 GPAM GPAT4 ETNK1 PNPLA3 PEMT CHPT1 CDIPT PNPLA2 CDS1 DGAT2 PCYT2 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260810%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON3 PON2 ESD PON1 CES5A LIPA CES2 CES1 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260810%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 FOXO1-1 NPAS2 ARNTL FBL CREB1 MAFG IRF2 POLR1E ALX1 CLOCK CREBBP SMAD4 PCNA NCOA3 DDX21 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260810%WP4521%HOMO SAPIENS Glycosylation and related congenital defects MGAT2 MPDU1 DPAGT1 ALG8 B4GALT1 ALG9 ALG6 TUSC3 MPI PMM2 SRD5A3 ALG2 ALG14 ALG3 DOLK MOGS ALG12 MAGT1 ALG1 ALG11 DPM1 GMPPB DPM2 DPM3 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260810%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway ALK CSF1R CNTF WNT2B NOTCH1 CSF1 EPO PDGFB PDGFA FGF2 FGF1 FGF4 INS;INS-IGF2 NTF4 NT5E SHH TPO FGF8 CXCR1 TNFSF11 WNT1 WNT2 IL6R IL11 TGFB3 WNT3A WNT7B FST LEFTY2;LEFTY1 HGF WNT5A NOG TGFB1 FLT3LG INHBA EGF DKK1 GDF5 IGF1 VEGFA BMP4 IL3 IL6 KITLG TF KIT NODAL FGF10 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling MAP2K3 PIK3CD PIK3R3 PIK3R2 PIK3CB PIK3R1 MAP2K2;MAP2K1 PIK3CA MAPK1 AKT1 MAP2K6 MAPK3 AKT2 AKT3 IL6 CD86 OTUD5 CD80 TBK1 IL12B MAP3K8 IL12A IFNAR2 USP7 FBXW5 TICAM2 CISH CD180 TRAFD1 TICAM1 RNF41 SIGIRR BTK RBCK1 CCL3L1;CCL3L3;CCL3;CCL18 SQSTM1 IFNAR1 LY96 PIK3R5 IRAK1 RNF216 IRAK2 RIPK1 FADD CD14 PLK1 SMAD6 NFKB2 NFKBIA CYLD CXCL10 CXCL11 TOLLIP TAB3 TAB2 TAB1 MYD88 CXCL9 CD40 CUEDC2 CXCL8 TNFAIP3 TREM1 PIK3CG CASP8 TNF MLST8 LBP TMED7 SYK SFTPD IRAK3 FOS RAC1 IRAK4 TIRAP TLR1 IRF3 TRAF3 MBL2-1 IL1B TRAF6 PELI1 TLR9 IRF7 TLR8 TLR7 IRF5 TLR6 ZMYND11 TLR5 TLR4 TLR3 TLR2 RNF31 PELI3 PELI2 RELA JUN MAPK9 CCL4L2;CCL4L1;CCL4 CCL5 TIFA MAPK14 SPP1 CTNNAL1 IFNB1-4 MAPK12 MAPK13 MAPK10 MAPK11 SARM1 PTPN6 IKBKB IKBKG IKBKE MAP3K7 MAP2K4 CHUK MAPK8 MAP2K7 NFKB1 SOCS1 STAT1 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260810%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine PNMT MAOB GCH1 MAOA ASMT DNAJC12 DBH COMT PTS QDPR AANAT DHFR2;DHFR SPR TH PAH BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260810%WP2366%HOMO SAPIENS Butyrate induced histone acetylation AKT1 ACLY PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260810%WP5103%HOMO SAPIENS Progeria associated lipodystrophy LMNB2 TGFB1 LMNB1 ZMPSTE24 WRN FNTA POLD1 FFAR3;GPR42 LMNA SPRTN SMAD2;SMAD3 PPARG BANF1 FBN1 INS;INS-IGF2 KCNJ6 SMAD4 ICMT PARP1 MUCL3 RECQL METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260810%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer SLC16A4 BCKDHA PDHX SLC16A1 PDHA1 MDH1 GFPT1 GLUD1;GLUD2 RPIA CS SLC7A5 PFKL LDLR PKM SOAT1 CARM1 RPE;RPEL1 FASN KRAS DLD BCAT2 ACLY GPI GOT1-1 GOT2-1 GLS2 SLC43A1 TP53 SLC2A1 UAP1 GPT SLC1A5 PDHB HMGCR HK2 HK1 LDHA ME1 PGM3 GNPNAT1 DLAT HMGCS2 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260810%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists CYP2C9;CYP2C19 NPC1L1 VDR NR1I2 CD36 PPARA PPARD SCARB1 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260810%WP322%HOMO SAPIENS Osteoblast signaling PTH1R IBSP ITGAV FGF23 SLC17A2 COL1A1 PDGFB TNFSF11 PDGFRB PDGFRA PTH ITGB3 TNFRSF11B LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260810%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH MDH2 NMRK2 NONO CS TFE3 HSPE1 SLC19A2 THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260810%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production PRKAA1 MAP2K2;MAP2K1 TPO MAPK1 RAF1 MAPK3 CREB1 NFKB1 PRKAA2 PRKCA ACY1;ABHD14A-ACY1 TRH ELK1 SLC5A5 RAP1B DUOX1 RAP1A CGA DUOX2 TSHR ANO1 CLCN5 TG PLCD1 SLC26A6 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260810%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation PLCG1 PLCD3 MAPK14 PLCD4 PIK3CD PIK3CB IKBKB PIK3CA IKBKG NFKBIA MAPK1 AKT1 CHUK MAPK3 CXCL8 PIK3CG TNF NFKB1 IL6 AKT2 AKT3 IL12B IL12A PLCB3 PLCB4 PLCB1 PLCD1 PLCB2 ITPR1 RETN RELA PLCG2 PLCE1 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260810%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NDUFA13 XIAP NOD1 NOD2 PRDM1 NLRC4 MEFV NLRP7;NLRP2 CASP9 PYCARD IKBKB CASP7 NLRP4 CASP1 IKBKG NFKBIA NLRP3 NLRP1 AAMP HSP90AA1 RIPK2 CARD9 CHUK ERBIN CARD6 IL18 CASP5;CASP4 NLRP12 COPS6 ACAP1 AIM2 NLRP10 CASP8 SUGT1 NAIP RAC1 IL1B DUOX2 RELA 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome PRKAA1 PRKAG1 PRKAG2 F11R PRKAG3 GJA1 AMELY;AMELX GJA3 ACP6 GJA5 OCLN-1 GJA8 PRKAA2 KIRREL1 PRKAB2 CHD1L PRKAB1 FMO5 PYGO1 TJP1 PYGO2 AFDN BCL9 CTNNB1 TJP3 TJP2 HEPATITIS B INFECTION%WIKIPATHWAYS_20260810%WP4666%HOMO SAPIENS Hepatitis B infection MAP2K3 PIK3CD PIK3R3 PIK3R2 PIK3CB PIK3R1 MAP2K2;MAP2K1 PIK3CA KRAS MAPK1 AKT1 RAF1 MAP2K6 MAPK3 CREBBP SMAD4 PCNA CREB1 AKT2 AKT3 ELK1 CASP9 TGFB3 IL6 TBK1 TICAM2 ARAF CREB3L3 CREB3L4 MYC TICAM1 CREB3L1 CREB3L2 EP300 PRKCG PRKCB HSPG2 ATF2 VDAC3 IFNAR1 ATF4 STAT5A IRAK1 STAT5B EGR2 TGFB2 EGR3 FADD SLC10A1 NFATC3 NFATC1 BRAF NFATC4 MAVS BCL2 GRB2 CDKN1A YWHAB FASLG TAB2 IFIH1 TAB1 YWHAQ MYD88 CASP10 JAK2 JAK3 HRAS CXCL8 APAF1 ATP6AP1 DDX58 TYK2 CASP8 YWHAZ TNF MMP9 DDB2 TGFBR2 DDB1 CASP3 CREB3 BIRC5 FOS SOS1 IRAK4 SOS2 TIRAP CREB5 ATF6B IRF3 CYCS-1 TRAF3 NRAS PRKCA STAT4 BID TRAF6 DDX3X-1 BAD STAT2 IRF7 FAS BAX SRC TLR4 TLR3 TLR2 PTK2B RELA JUN MAPK9 MAPK14 IFNB1-4 MAPK12 MAPK13 MAPK10 TGFBR1-1 MAPK11 IKBKB IKBKG IKBKE MAP3K7 MAP2K4 CHUK MAPK8 MAP2K7 TGFB1 MAP3K1 NFATC2 NFKB1 SMAD2;SMAD3 STAT6 JAK1 STAT1 STAT3 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260810%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GALT2 B3GNT5 B3GALT1 FUT2 FUT6;FUT5;FUT3 FUT1 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260810%WP696%HOMO SAPIENS Benzo a pyrene metabolism EPHX1 CYP1A1 AKR1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1B1 RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260810%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation EPHB2 LTB4R PDK1 CMKLR1 AKT1 PIK3CD PIK3CB MTOR GRK1 PIK3CA PIK3CG FPR2 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260810%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway CHKB MOGAT3 PIK3CD PGS1 PTPMT1 CRLS1 PIP5K1A GPAT3 GPAT2 PIK3CB PTDSS1 CEPT1 PLA2G2A-1 GK GPAM GPAT4 IPMK GNPAT PIK3CA GPD1 AGPS PEMT CHPT1 LPIN1 CDIPT LPIN2 PI4K2A CDS2 PIK3CG PCYT2 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260810%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma NFKB1 IL6 JAK1 IL11RA ZEB1 IL6ST IL6R SOX4 IL11 STAT3 JAK2 JAK3 RELA ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2858%HOMO SAPIENS Ectoderm differentiation FZD5 FZD4 SMURF1 ZBTB16 GREB1 FZD8 NR2F2 POU2F2 ZFHX4 PAN2 AHI1 PTPRB PLCXD3 MAFB PPFIBP2 LHX1 CCDC88C PI4KA MKS1 NF2 CCDC130 BMPR1A EDA NUMA1 FHL2 HMGB2 LDB2 PPARD GLI3 SMAD4 EDA2R WDR44 PHF8 TNFRSF11B MECP2 SIX6 BOC UBTF PGM1 RAB8B ABCC4 BCAS3 ELOVL4 TSC22D1 ELOVL2 PAX3 SORCS1 PAX6 BAZ1A FOXL1 CLDN11 ARHGAP10 TOX3 KIFC3 NLGN1 STX16 RRBP1 JAKMIP1 IQCJ-SCHIP1;SCHIP1 DMD CTNNA2 SERPINB6-2 CAP2 SNCA CLVS1 TTC14 TCF7L1 C1GALT1 PTPN13 VAX2 RIT1 GLB1 SGSM3 ZNF219 SPRY2 BCOR PDE7A TRIM33 MYORG FOXA2 SHH WNT1 PRKAG2 BMP4 CTNNB1 MYC HDAC10 NFATC1 HDAC6 RGMA CCL13;CCL2 FYN CTNND2 ARHGDIG CELSR2 CDH8 TSKU SOX2 CDH6 NARS2 PIM1 CDON ANKS1B KCNK10 GRAMD1B-1 TLE5 KRT6B;KRT6C;KRT6A ROR2 MZF1 LY6E ASTN1 CTBP1 FGFR2 ARX GATA6 STC1 ARHGAP15 NLK ZBTB2 SOCS2 TRPM2 SDCBP PODXL ST8SIA4 HESX1 PLXNA2 OGT-1 ZBTB7B GAS2L1 SKIL TFAP2A TFAP2C JUP ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260810%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease ESR1 CALM1 SP1 SP3 KCNN3 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260810%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 STAT5A STAT5B ESR1 CEBPA CEBPB PNCK NFIX TNFSF11 PRL ATP2C2 EIF4E CHUK TNFRSF11A NR3C1 JAK2 NRG1 EGFR YY1 CCND1 ERBB3 ERBB4 ERBB2 DLGAP4 PTPN1 TPM3 CAV1 TFPI2 PRLR USF2 USF1 ESR2 CLDN6 TTC9 GJB2 CSN2-1 GAL NFIA NFIB ELF5 NFIC ORAI1 PGR HDGFL2 BCL2L1 EIF4G1 MYC PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260810%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response UBE2E1 EIF2AK3 EDEM1-1 ASNS PDIA6 ATF4 WARS1 ERN1 DNAJC3-1 DDIT3 DNAJB11 TRIB3 ERP27 ATF6 ATF3 NFE2L2 PPP1R15A CALR-1 BBC3 HSP90B1 BCL2L11 NARS1 DNAJB9 EIF2A XBP1 HSPA5 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260810%WP4157%HOMO SAPIENS GABA metabolism aka GHB ALDH5A1 GLS2 ABAT ADHFE1 DPEP1 PON3 GAD1 GLS GAD2 MAOB AKR7A2 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260810%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells PDK1 MAPK14 MAP2K3 PIK3R3 MAPK10 PIK3R2 PIK3CB PIK3R1 MTOR MAP2K2;MAP2K1 PIK3CA EIF4EBP1 MAPK1 EIF4A2 AKT1 EIF4A1 MAP2K4 RPTOR EIF4E RPS6KA4 PRKACA-1 MAP2K6 RPS6KA5 RPS6KA2 MAPK3 RPS6KA1 MAPK8 PIM2 EIF4B PIK3CG MAP2K7 RPS6 MAP2K5 PRKCD PIM1 RPS6KB1 RPS6KB2 PDCD4 CSNK2A1;CSNK2A3 EIF4G3 AKT2 AKT3 PRKCA EIF4G1 MAPK9 NAD METABOLISM%WIKIPATHWAYS_20260810%WP3644%HOMO SAPIENS NAD metabolism NRK SIRT4 SIRT5 NMNAT3 SIRT6 NMNAT2 SIRT1 SIRT2 SIRT3 NMNAT1 NT5E NAMPT CD38 NADK PARP1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260810%WP2361%HOMO SAPIENS Gastric cancer network 1 ACTL6A TPX2 CCNA1 SMOC2 CENPF APC NOTCH1 MCM4 RNF216 S100P GATD3B;GATD3A KIF20B H4-16 TOP2A INO80D NUP107 LIN9 AURKA KIF15 ESM1 RUVBL1 CEP192 MYBL2 ECT2 H3-3A E2F7 UBE2C PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260810%WP4971%HOMO SAPIENS Phosphoinositides metabolism PIK3CD PIK3CB PIK3CA PIK3CG PLCB3 PLCB4 PLCB1 PLCD1 PLCB2 INPP5D PLCG2 PLCE1 PLCG1 PLCD3 PLCD4 PIP5K1A MTMR10 MTMR12 MTMR11 PTEN PIK3C2G PIK3C2A PIK3C2B PIP4P2 PIP4P1 PLCZ1 PIP4K2A PIP4K2B PIP4K2C SBF1 SBF2 SACM1L OCRL PIK3C3 MTMR1 MTMR2 MTMR3 MTMR8 PIK3R4 MTMR9 MTMR4 MTMR6 MTM1 MTMR7 PIP5K1B PIP5K1C PIKFYVE PLCH1 PLCH2 SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260810%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling CREB1 ATF1 EGR1 SRF BRAF MAP2K2;MAP2K1 HTR4 ELK1 GNAS-1 ELK4 HTR6 HTR7 RAP1A MAPKAPK2 MAPK1 NR3C1 RPS6KA5 MAPK3 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260810%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism CYP11B1;CYP11B2 CYP21A2 CYB5A H6PD SRD5A2 HSD17B3 CYP19A1 CYP17A1 HSD11B1 HSD11B2 POR HSD3B1;HSD3B2 STAR CYP11A1 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260810%WP707%HOMO SAPIENS DNA damage response RB1 MRE11 CDKN1B HUS1B BRCA1 PIDD1 CCND3 CCND2 SESN1 CHEK2 CHEK1 TLK2 TLK1 NBN RFC1 SMC1A CDKN1A CDC25C CDC25A AKT1 CCNE2 RRM2B FANCD2 CCNE1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PRKDC MDM2-2 APAF1 CCNB3 CCNB2 E2F1 ABL1 CASP8 PMAIP1 SFN DDB2 ATRIP GADD45B GADD45A CASP3 CREB1 RPA2 PML GADD45G RAD52 RAD50 CDK6 CYCS-1 RAD51 CDK5 CDK4 BID CDK2 CDK1 RAD17 RAD1 TP53 FAS ATM BAX RAD9A ATR CASP9 CCND1 CCNB1 BBC3 MYC COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260810%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence ANO6 IL17RC IL17A IL17RA TLR4 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260810%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway EPHX2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PPARA PPARG CYP2C18-1 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260810%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGO PGAP3 PIGN GPAA1 PIGQ PIGP PIGW PIGV PIGX-1 PIGC PIGB PIGA PIGK PIGM PIGL MPPE1 PIGG PIGF PIGH PIGS PIGU PIGT PGAP1 DPM2 PGAP2 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260810%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 MGMT 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260810%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb PRKAA1 MTOR MAP2K2;MAP2K1 MAPK1 RPTOR MAPK3 RPS6KA1 MLST8 RPS6KB1 PRKAA2 CDK2 CDK1 MAPK14 MAPK12 MAPK13 MAPK11 COX7C EEF2K UQCRFS1 RAB5IF NDUFS8 UQCRC1 NDUFS3 UQCRC2 CDH18 UQCRB UQCR11 PRKAG1 UQCR10 PRKAG2 COX5A TRPM7 PRKAG3 CYC1 PDZD9 NDUFV1 CDR2 NDUFA9 TRAP1 CALM1 NDUFA4 SDR42E2 VWA3A PRKAB2 EEF2 CALM3;CALM1 PRKAB1 MOSMO-1 UQCRQ POLR3E CALM2 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260810%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling VCAM1 BIRC3 PTGS2-2 SELE IKBKB NFKB2 CHUK TNFRSF1A CXCL8 CCND1 TNF MMP9 ICAM1 VEGFA BIRC5 NFKB1 IL6 IL1B TRAF6 IL1A CSF2 BCL2A1 RELB EGLN2 MMP1 MMP2 MMP3 CXCL2;CXCL3;CXCL1-1 CFLAR IL2 CD40LG REL RELA BIRC2 BCL2L2 TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260810%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HGD TAT FAH HPD OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260810%WP12%HOMO SAPIENS Osteoclast signaling SPP1 IFNAR1 IFNB1-4 ATP6V1G1 GPR68 PDGFB SLC9A1 AIMP2 CTSK TRPV5 ACP5 TNFSF11 TNFRSF11A MAPK8 ITGB3 TNFRSF11B FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260810%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 APOA2 LPL LCAT APOA1 LIPC APOC2 LDLR LRP1 SEL1L APOA4 APOA5 LMF1 PLTP GPIHBP1 CETP FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260810%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling FOXO1-1 RPS6KB1 RPS6KB2 MAPK14 CREB1 TSC2 PRKCA MTOR EIF4EBP1 MAPK1 SRC AKT1 CGA FSHB RAF1 SGK1-1 RHEB PRKACA-1 FSHR GRK6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MAPK3 APPL1 RPS6 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260810%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors HMGCR MVD SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260810%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 FADS2 ACSL1 ALOX5 VITAMIN D METABOLISM%WIKIPATHWAYS_20260810%WP1531%HOMO SAPIENS Vitamin D metabolism CYP27A1 RXRB CYP27B1 RXRA CYP24A1 VDR CYP2R1 DHCR7 GC PTH S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260810%WP26%HOMO SAPIENS S1P receptor signal transduction MAPK12 PIK3C2B MAPK1 AKT1 MAPK3 MAPK7 ASAH1 GNAI3 AKT2 GNAI1 AKT3 GNAI2 SMPD2 RACGAP1 S1PR1 S1PR3 S1PR2 MAPK6 S1PR5 MAPK4 PLCB3 SPHK2 SPHK1 PLCB1 PLCB2 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260810%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 APOA2 LPL LCAT APOA1 LIPC APOC2 LDLR LRP1 SEL1L APOA4 APOA5 LMF1 PLTP GPIHBP1 ANGPTL8 ANGPTL3 ANGPTL4 CETP WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260810%WP399%HOMO SAPIENS Wnt signaling and pluripotency FZD5 FZD4 FZD8 CCND3 CCND2 PPARD CREBBP RHOA TCF7L1 WNT2B LDLR WNT1 WNT2 WNT3A CCND1 WNT7B WNT5A CTNNB1 MYC EP300 PRKCG PRKCB PRKCD PPP2R1B PRKCA RACGAP1 TP53 CTNND1 PTPA FZD10 PLAU PPP2R1A PRKCI PRKCH JUN MAPK9 WNT5B PRKCE ZBTB33 FBXW2 PRKCQ PPP2R2A;PPP2R2D APC CTBP2 TCF7 POU5F1;POU5F1B GSK3B MAPK10 PRKCZ WNT6 DVL1 DVL2 DVL3 WNT3 WNT4 FZD1 MAP3K7 WNT10B WNT10A FZD3 FZD2 MAP2K4 FZD7 FZD6 ESRRB FZD9 FOSL1 PRKD1 NANOG;NANOGP8 NFYA-1 TPTEP2-CSNK1E;CSNK1E SOX2 PPP2CB;PPP2CA LRRK2 PPP2R5E FOXD3 MMP7 AXIN1 WNT9B AXIN2 PPP2R5C WNT16 CD44 PAFAH1B1 LEF1 LRP5 CTBP1 PPM1J NKD1 LRP6 NKD2 WNT11 NLK TCF7L2 WNT7A PPP2R3B PPP2R3A PPP2R2C PPP2R2B MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260810%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling SLPI MST1R NDRG1 ACACA SOCS3 PPARGC1A SMAD1 SMAD9 NR0B2 SMAD5 NR4A1 PIK3R1 SNAI2 SP7 MTOR FGFR1 MAP2K2;MAP2K1 ITGB1 FLT1 SIX1 HSPB1 DUSP4 DUSP1 MAPK1 AKT1 MST1 RAF1 GAB1 DUSP6 ZEB2 KLK15 VIM MAPK3 SHC1-1 PDGFRB PDGFRA PCNA ABL1 IBSP PRKAA2 ELK1 PTK2 PLCG1 VEGFA IL6 OCLN-1 FN1 TJP1 CSF2 CTNNB1 COL4A1 CXCL2;CXCL3;CXCL1-1 PRKCB SMAD6 CXCL10 GRB2 RPS6KA4 RPS6KA5 RPS6KA1 CXCL8 RPS6 TNF MMP9 RPS6KB1 PDCD4 KDR FOS IL10 IL1B TP53 CCL13;CCL2 SRC RELA JUN MAPK9 MAPK14 IFNB1-4 GSK3B PTEN FZD1 WNT10B ZEB1 PDPK1 MAPK8 PARP1 TGFB1 NFKB1 SMAD2;SMAD3 EGR1 SOCS1 SLC2A1 CSF3 CLDN1 IGF1R HK2 CRKL RPS6KA3 LDHA CDH2 ACTA2 CDH1 CXCL5;CXCL6 CPT1A CLDN5 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260810%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling STAT2 JAK1 STAT1 IL6 STAT3 IL10 IL10RB IL10RA HMOX1 BLVRB IL1A BLVRA ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260810%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology TGFB2 MAP2K2;MAP2K1 GRB2 KRAS MAPK1 TGFB3 HRAS MAPK3 SMAD4 ADCY4 ADCY3 TGFB1 ADCY2 ADCY1 SYNE4 ADCY8 SYNE3 CCN2 SOS1 ADCY7 SOS2 ADCY6 SYNE2 SMAD2;SMAD3 SYNE1 ADCY5 NRAS BANF1 TMEM43 SRF KIF5B CFL1 MAP3K9 LBR RHOA EMD TMPO WWTR1 SUN1 LEMD3 ADCY10 ADCY9 PLEC PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260810%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells VCAM1 TGFB1 ICAM1 CCL5 SELE TGFB2 IL1B CCL13;CCL2 TLR7 TLR4 CD40 SELPLG TGFB3 PF4;PF4V1-1 TLR2 SELP CD40LG HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260810%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway HIF1A PRKAG1 ACACB PDK1 ACACA PRKAA1 PDHA1 VEGFA NFE2L2 PRKAB1 TP53 SLC2A1 PDHB LDHA EGLN1 CUL3 RPS6 SLC11A2 KEAP1 PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260810%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS CDKN1B ITGB1 CDKN1A AKT1 YWHAQ VIM PCNA ITGB3 ITGB4 ITGAV PTK2 TLR4 FYN PLCE1 PLCG1 CDKN1C SCARB2 SMARCAL1 PTPRO ILK NOTCH1 MKI67 DAG1 SYNPO NCK1 KIRREL3 CTSV;CTSL TRPC6 KIRREL2 MME ITGA3 PLAUR KRT8 ACTN4 DNM1 PAX2 WNT1 CD2AP INF2 COL4A4 COL4A3 COL4A5 MYH9 IRF6 LMX1B UTRN TLN1 VCL CAMK2B TGFB1 LAMA5 DKK1 CD151 VTN JAG1 CR1L;CR1 PARVA MYO1E LIMS4;LIMS1 LRP5 NPHS1 NPHS2 WT1 LRP6 LAMB2 FAT1 AGRN CD80 PODXL CTNNB1 CLDN1 CDH2 SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260810%WP1455%HOMO SAPIENS Serotonin transporter activity IL1R1 TGFB1I1 NOS1 STX1A SCAMP2 SLC6A4 IL1B PPP2CB;PPP2CA ITGB3 TPH2 MAOA PDGF PATHWAY%WIKIPATHWAYS_20260810%WP2526%HOMO SAPIENS PDGF pathway PLCG1 PTPN11 PDGFB PDGFA PIK3R1 MAP2K2;MAP2K1 NFKBIA GRB2 MAPK1 MAP2K4 RAF1 CHUK HRAS MAPK3 SHC1-1 PDGFRB MAPK8 MAP3K1 FOS NFKB1 SOS1 RAC1 SRF ELK1 RHOA JAK1 SRC WASL STAT1 CDC42 PAK1 STAT3 ARFIP2 PLA2G4A VAV1 VAV2 TIAM1 RASA1 JUN FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260810%WP1601%HOMO SAPIENS Fluoropyrimidine activity DPYS TYMP CYP2A13;CYP2A6;CYP2A7-1 PPAT TDG FPGS UPP1 TK1 ABCC3 RRM1 ABCC5 XRCC3 GGH UPB1 TYMS SMUG1 UCK1 ERCC2 DPYD UMPS SLC29A1 MTHFR RRM2-1 SLC22A7 ABCG2 DHFR2;DHFR CES2 CES1 ABCC4 TP53 CDA CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260810%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin MAP2K2;MAP2K1 PLCZ1 MAPK1 RAF1 GUCY1B1 NPR1 FHL2 PRKACA-1 FHL1 MDM2-2 CAMK2A ADRB1 ADRB2 MYPN PRKACB-1 GUCD1 CSRP3 NUP62 ANKRD1 PRKG2 ANKRD2 TRIM63 ANKRD23 TTN-1 PRKAR1A NBR1 TCAP CRYAB PRKCA TRIM55 SRF TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260810%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC PRKAA1 PRKAG1 PRKAG2 PRKAG3 CCN2 YAP1-1 PRKAA2 TEAD1 STK4 TEAD2 PRKAB2 STK3 TEAD3 SAV1 TEAD4 PRKAB1 RHO RHOA CCN1 RHOC MOB1A;MOB1B RHOD LATS1 RHOB LATS2 HMGCR ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260810%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis RHOA GNA13 TBXA2R GNA12 TBXAS1 ARHGEF1 PTGS1 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260810%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAPK14 MAP2K3 ATF4 MAPK12 MAPK13 MAPK10 MAPK11 MAP2K2;MAP2K1 BRAF MAP3K7 MAPK1 DUSP1 MAP2K4 RAF1 MAP3K11 MAP2K6 MAP3K5 MAPK3 MAPK8 PARP1 MAP2K7 MAP3K1 MAP3K9 MAP3K8 ARAF TNKS MAP3K21 PARP14 MAP3K10 MAPK9 MAP3K12 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260810%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis SPI1 IRAK1 TLR4 APOE TLR2 TRAF6 RELA NFKB2 BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260810%WP5031%HOMO SAPIENS Biotin metabolism including IMDs MCCC2 ACACB PC BTD ACACA PCCA HLCS MCCC1 PCCB SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260810%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IFNAR1 IFNB1-4 ACE2 IRF9 IRF3 TRAF3 MAVS STAT2 IKBKE TBK1 JAK1 IFNAR2 IFIH1 STAT1 TLR3 TICAM1 DDX58 TYK2 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP496%HOMO SAPIENS Steroid biosynthesis HSD17B3 CYP17A1 HSD17B1 HSD17B2 HSD17B4 HSD3B1;HSD3B2 F13B HSD17B7 CPN1 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260810%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways PBX1 PHOX2A TLX3 FEV BHLHE40 PPARGC1A GNB3 CC2D1A POU2F2 TP73 RET YWHAE RYR2 SNAP25 HADHB-1 THRB CDCA7L ECE1 YBX1 HTR2A CTCF FOXM1 GAPDH-1 SCN5A ACADM YWHAG NKX3-1 SNTA1 YWHAH CREBBP IL13 EN1 HTR3A TACR1 MECP2 SSTR1 NGF SSTR2 HADHA NOS1AP CREB1 AVP ALDOA SLC25A4 SCN4B VAMP2 DDC CHRNA7;CHRFAM7A ATP1A3 ASCL1 HSPD1 HES1 HES5 NTRK2 KCNJ8 MBD1 FMO3 GCK GRIN1 REST SST PLP1 HIF1A SP1 SP3 CEBPB IL6R NR3C1 GABRA1 LMX1B GJA1 VEGFA ESR2 IL6 TF TPH2 SLC6A4 CTNNB1 HSP90B1 EP300 HDAC1 NFKB2 HDAC9 YWHAB YWHAQ PRKACA-1 CXCL8 PRKACB-1 YWHAZ TNF CASP3 PRKAR1A IL10 IL1B IL1A JUN POU5F1;POU5F1B MAOA CHRM2 VIPR1 IL1RN VIPR2 RORA AQP4 MYB LOC110384692;C4A;C4B_2;C4B PKNOX1 TH CHRNB2 PAH KCNH2 NANOG;NANOGP8 CHRNB4 NFYA-1 MEF2C SOX2 TSPYL1 GPD1L-1 RUNX3 POU3F2 SLC9A3 AR ADCYAP1 PRKAR1B KCNQ1 TPH1 NFKB1 ADCYAP1R1 DLX2 CHRNA4 MAZ CHAT CREM EGR1 SLC1A3 GATA3 GATA2 NEUROD1 MAP2 PRKAR2B DEAF1 PRKAR2A TPPP SCN3B TAC1 PPARGC1B SPTBN1 NKX2-2 CAV3 BDNF HTR1A CPT1A G6PC1 PHOX2B APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260810%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 MAP3K1 CASP3 NFKB1 MAPK10 RIPK1 CYCS-1 FADD CASP9 CASP7 BID FAS FASLG HSPA1A;HSPA1B TNFRSF1A AIFM1 APAF1 CASP6 CASP2 CASP8 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260810%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases L2HGDH ADHFE1 ALDH7A1 MDH2 GCDH ACY1;ABHD14A-ACY1 IDH2 D2HGDH GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260810%WP4823%HOMO SAPIENS Genes controlling nephrogenesis ROBO2 NOTCH2 FOXC2 FOXC1 TCF21 ILK HOXD11 RET HOXA11 PDGFB NCK2 SLIT2 NCK1 EMX2 FOXD1 EYA1 MAFB ITGB1 MAGI2 WNT4 HNF1B LHX1 SIX1 SHH ITGA3 ETV4 CXCL12 FGF8 GDNF ITGA8 PAX2 CD2AP CD36 GLI3 PDGFRB LMX1B KDR VEGFA NPHS1 NPHS2 FGFR2 KIRREL1 WT1 LAMB2 CXCR4 CTNNB1 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260810%WP3972%HOMO SAPIENS PDGFR beta pathway PLCG1 PRKCB STAT5A STAT5B PIK3R1 MAP2K2;MAP2K1 PIK3CA GRB2 EIF2AK2 MAP2K4 RAF1 JAK2 HRAS MAPK3 SHC1-1 PDGFRB MAPK8 MAP3K1 FOS SOS1 PRKCA SRF ELK1 STAT6 JAK1 STAT1 STAT3 RASA1 JUN UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260810%WP4595%HOMO SAPIENS Urea cycle and associated pathways NAGS SLC25A12 OTC SLC25A13 FH MDH1 MDH2 GLUD1;GLUD2 GOT1-1 GOT2-1 GLS2 NOS1 GPT OAT NOS2 NOS3 ARG1 PYCR1 ASS1 ALDH4A1 SLC25A15 LDHB CPS1 ASL INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260810%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide TLR9 TNF BECN1 MAP1LC3A IFNB1-4 IFNG NFKB1 MYD88 TLR4 IRF3 TRAF6 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260810%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation FGFR1 ITGB1 FLT1 KRAS NF2 FOXM1 MST1 PDGFRB PDGFRA ITGB3 ITGAV YAP1-1 TEAD1 TEAD2 TEAD3 TEAD4 NTRK2 PTK2 WWTR1 LATS1 PLCB4 LATS2 CSF1R ITGA3 ITGA8 EGFR CCND1 CDH18 BUB1B-PAK6;PAK6 ITGA2B CDH9 AMOT CDH7 KIT PPP1CB ITGB5 DCAF1 PPP1CC CDH4 CDH3 ITGA1 RBX1 AJUBA EPHA2 CDH20 CDH22 CDH24 CTNNB1 NGFR INSR PAK1 LIN28B ITGA10 FGFR4 MYC ITGA11 FGFR3 ITGAM FLT3 FLT4 ITGB2 ITGB6 ITGAE ITGAL ITGAX ITGB8 ITGB7 PPP1R12A ITGA4 ITGA2 ITGAD CDH10 CDH11 CDH12 ITGA7 CDH13 ITGA6 CDH15 CXCL10 ITGA5 CDH16 MET CDH17 VGLL4 CDH19 ITGA9 PRKACA-1 CTNNA1 PAK3 HRAS PAK2 PAK5 PAK4 NTRK1 PRKACB-1 PPP1R14A ITGB4 CUL4A TEK CDH5 DDB1 KDR CCN2 PRKAR1A NRAS STK3 SAV1 PPP1CA CDH8 CDH6 PRKAR1B CD44 FGFR2 PRKAR2B PRKAR2A IGF1R CDH2 CDH1 SLC25A46 PATHWAY%WIKIPATHWAYS_20260810%WP5521%HOMO SAPIENS SLC25A46 pathway APOOL MMGT1 IMMT EMC10 MICOS13 MICOS10 APOO CHCHD3 OPA1 CHCHD6 EMC1 EMC2 MFN1 EMC3 MFN2 EMC4 EMC6 EMC7 DNM1L EMC8 SLC25A46 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260810%WP2290%HOMO SAPIENS RalA downstream regulated genes KRAS EXOC8 CDC42 RALBP1-1 RAC1 RAC3 RALA-1 YBX3 HRAS NRAS EXOC2 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260810%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 IRAK1 IKBKB NFKB2 IKBKG IKBKE MAPK1 TOLLIP CHUK MYD88 NFKB1 IRAK4 TIRAP TLR1 IRF3 TRAF3 TRAF6 TLR9 TBK1 IRF7 TLR8 TLR7 RELB TLR6 TLR5 TICAM2 TLR4 TLR3 TLR2 TICAM1 REL RELA JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260810%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells AKT1S1 SOCS3 STAT5A STAT5B EPO CCND3 CCND2 MTOR KRAS FOXM1 AKT1 PRL RPTOR IL6R JAK2 HRAS MLST8 PRLR IFNG IL6 AKT2 NRAS AKT3 CDK4 SOCS1 SOCS2 STAT1 STAT3 CISH GHR IFNGR1 IFNGR2 EPOR STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260810%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling ACACA PRKAA1 MDH1 GPAM ATF6 MTOR PIK3CA FASN AKT1 PRKACA-1 MVD CREB1 SIRT1 PRKAA2 SCARB1 GSK3A MED15 LPL HMGCS1-1 CAMP SREBF1 SEC13 LSS SREBF2 RBP4 KPNB1 IDI1 SEC23A LDLR INS;INS-IGF2 SAR1A SP1 INSIG2 SAR1B INSIG1 LPIN1 RNF139 SCAP ACSS1 SEC23B SEC31B FDFT1 FGF21 SEC31A FDPS YY1 ACLY MBTPS1 SEC24B NFYA-1 SEC24A AMFR NR1H2 CYP51A1 SEC24D-1 PRKAG1 SQLE PRKAG2 CDK8 SCD PRKAG3 SEC24C MBTPS2 PPARG PRKAB2 PRKAB1 HMGCR PPARGC1B CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260810%WP4191%HOMO SAPIENS Caloric restriction and aging TP53 AKT1 IGF1 PPARGC1A SIRT1 MTOR PRKAB2 NAMPT NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2064%HOMO SAPIENS Neural crest differentiation TCF4 TFAP2E;TFAP2B DMBX1 ZIC1 HEY2 OLIG3 SMAD1 OLIG1 OLIG2 COL2A1 DCT PAX7 SNAI2 HAND1 COL11A2 FGFR1 WNT8A ITGB1 DLL1 LHX1 DLL3 PRTG DLL4 GBX2 MSX1 TBX6 PMP22 NEUROG1 PAX3 ASCL1 HES1 HES5 TCF7L1 NOTCH2 NOTCH1 FGF8 WNT1 WNT3A BMP4 CDH7 CTNNB1 MYC FGFR3 HDAC4 HDAC5 HDAC2 HDAC3 HDAC10 HDAC1 HDAC8 NFKB2 HDAC9 HDAC6 HDAC7 RHOB CTBP2 GSK3B FGF2 DVL1 DVL2 DVL3 FZD3 MYB CDH6 FOXD3 AXIN1 AXIN2 HDAC11 NFKB1 RBPJ ETS1 MPZ HOXA1 SOX9 FGFR2 SOX5 MIA MSX2 MITF SOX10 ISL1 HOXB1 NOTCH3 DLX5 NOTCH4 MBP BMP7 GFAP GJB1 LHX2 CDH2 TLX2 CDH1 FGF19 TFAP2A ID1 SNAI1 PHOX2B LHX5 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260810%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway ACACA MECR OXSM HSD17B12 MCAT STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260810%WP383%HOMO SAPIENS Striated muscle contraction pathway ACTN4 VIM MYOM1 ACTC1;ACTG2 ACTG1 TNNI1 TNNI2 TNNI3 MYBPC3 TPM3 TMOD1 MYBPC1 MYBPC2 ACTN3 TPM4 ACTN2 TTN-1 TNNC1 TPM2 TPM1 TCAP TNNC2 NEB MYL4 ACTA1 MYH3 DES MYL1 TNNT1 TNNT2 MYL2 MYL3 TNNT3 MYH8 DMD MYH6 ACTA2 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260810%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP UBE2E1 CDKN1B EHMT2 CDKN1A MAPK1 RPS6KA2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MAPK3 CXCL8 RPS6KA1 H2BC15;H2BC3;H2BC11;H2BC12 H4-16 H4C1 H4C6 FOS CDK6 CDK4 CDK2 IL1A UBE2D1 EHMT1 CDC23 H2AC14 H2BC21 H3-3A CDC26 RELA CDC27 JUN UBE2C CCNA2-1 ANAPC7 H2AC4 CCNA1 H2AZ2;H2AZ1 H2AJ ANAPC4 ANAPC5 UBA52 ANAPC1 ANAPC2 ANAPC15 ANAPC16 ANAPC10 ANAPC11 FZR1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 IGFBP7 RPS27A CEBPB UBB;UBC CDKN2D CDKN2B CDKN2C H2BC5 CDKN2A H2BC1 UBE2S H2AC20 CDC16 H2AB2;H2AB3;H2AB1 MAPK7 NFKB1 IL6 STAT3 RPS6KA3 METHYLATION PATHWAYS%WIKIPATHWAYS_20260810%WP704%HOMO SAPIENS Methylation pathways MAT2B HNMT INMT COMT MAT1A PNMT NNMT TPMT MAT2A ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260810%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease EGF HTT GRM1 CREB1 CASP3 CASP7 MAP2K2;MAP2K1 ELK1 NTRK2 MAPK1 RAF1 EGFR RPS6KA5 HRAS MAPK3 BDNF ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260810%WP106%HOMO SAPIENS Alanine and aspartate metabolism ABAT PC GAD1 GPT AGXT GAD2 ASPA DARS1 ASS1 GOT1-1 GOT2-1 ASL AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260810%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension GLUD1;GLUD2 HAL UROC1 AMDHD1 GPT2 FTCD FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260810%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins RB1 FADD CASP9 CASP7 BCL2 HSPB1 MAP3K7 FASLG RIPK2 MAP2K4 CASP10 PRKDC PAK2 APAF1 MAPK8 ACTG1 PARP1 DAXX CASP8 TNF LMNB2 LMNB1 MAP3K1 CASP3 SMIM40 LMNA CYCS-1 FAF1 ARHGDIB ACTA1 SPTAN1 IL1A DFFB DFFA FAS MAPKAPK3 NFX1 MAPKAPK2 ACTB-1 PAK1 CFLAR CASP6 JUN GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260810%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease GTF2I EFL1 CYBB CYBA SHCBP1 ARHGAP31 NOTCH1 IBTK EIF6 EOGT SBDS NOX3 SP1 KCNN3 ESR1 DLL4 MAPK1 MAPK3 NFKB1 RBPJ RAC1 TLR9 TLR8 DOCK6 NOTCH4 CYBC1 NCF1 CDC42 NCF2 NCF4 COX4I2 CXXC5 DGUOK CHCHD2 C4orf54 BEND6 BTK GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260810%WP334%HOMO SAPIENS GPCRs class B secretin like PTH1R ADCYAP1R1 GLP1R CALCRL GIPR GCGR GLP2R SCTR VIPR1 PTH2R CRHR1 VIPR2 CRHR2 ADGRE1 GHRHR ADGRG2 CALCR ADGRE5 ADGRL1 ADGRL4 ADGRL2 ADGRL3 NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway RIPK1 FADD NFKBIA MAVS CYLD CXCL10 IFIH1 CASP10 CXCL8 TRADD DDX58 DHX58 CASP8 TRIM25 TNF AZI2 DDX17 TRAF2 SIKE1 ATG12-1 RNF125 IFNE IFNK NLRX1 TANK IRF3 TKFC TRAF3 ATG5 ISG15 SNW1 TRAF6 DDX3X-1 STING1 PIN1 TBKBP1 IRF7 NFKBIB RELA MAPK9 MAPK14 IFNB1-4 MAPK12 MAPK13 MAPK10 MAPK11 IKBKB IKBKG IKBKE MAP3K7 CXCL12 CHUK MAPK8 MAP3K1 IFNG NFKB1 OTUD5 TBK1 METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260810%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts PLCG1 PSAT1 P4HA3 ALDH18A1 SLC16A1 GLUD1;GLUD2 FGFR1 GLS CD36 PYCR1 PGM1 GPI RHOA SLC2A1 LPAR1 PLOD1 LOXL2 GCK SLC1A5 ADAMTS2 UGP2 SERPINH1 PHGDH PSPH LDHA P3H4 P3H3 FGFR4 UGDH BMP1 P4HA1 P4HA2 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260810%WP2006%HOMO SAPIENS miR targeted genes in squamous cell MTPN MRPS33 AKAP8 DNAJB1 POLR2C PPP1R7 SMAD1 GFPT1 POLD2 PISD SH3BP4 E2F3 PDLIM7 MPZL1 SLC12A2 PKM GALNT7 GALNT1 TXNRD1 AP3D1 ARCN1 SPCS3 TMEM59 NF2 ATP6V0E2;ATP6V0E1 FMNL2 AXL NEDD4 LAMTOR5 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CUL4B HSD17B12 BET1 HMOX1 ATRX SYNE2 TPM1 TMEM43 HES1 MAGT1 ANXA2 AP2A1 TPM3 LAMC1 MAP3K8 THBS1 MET YWHAQ RHEB TMED7 TGFBR2 PDCD4 GNAI2 P4HA2 VCAM1 CPNE8 VEZT ACAA2 SRPRB-1 ARF4-1 PWP1 DHX57 FGF2 ANPEP ARFIP1 CIAO2A SEC23A HOXA7 POGLUT3 SLC38A1 RARS1 FBXW11 FNDC3B GOLGA7-1 FNDC3A DHX40 RAB34 RAI14 SRSF9 TMED10 CBFB ADIPOR2 RTN4 UBE2J1 MRPL20 COMMD9 SLC38A2 ATP6V1C1 ATP6V1F PEDS1-UBE2V1;PEDS1 IDH1 SLC4A10 TBCA MOV10 NCL-1 HNRNPM CHMP2A ANP32B PICALM NRP1 TRAM1 ATP2A2 ADAR MRC2 GYS1 TUBA1A SDCBP SPTLC1 PODXL SH3BGRL3 TMED2-1 ELOVL5 SIGMAR1 PRPF40A CTDSP1 GAS2L1 CSDE1 POM121;POM121C PXDN PNP-1 PTMA FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260810%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling AKT1S1 PDK1 PLD1 PPARGC1A ILK GSK3B MTOR PTEN ITGB1 AKT1 RPTOR EIF4E TNFRSF1A MSTN IRS1 MAPKAP1 DEPTOR PIK3CG RICTOR EIF2B2 MLST8 IGFBP5 RPS6KB1 FBXO32 ACVR2B TNFSF9 MAP1LC3A TRIM63 IGF1 NFKB1 SMAD2;SMAD3 NEB PRKAB1 WASL IGF1R ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260810%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling PTPN11 MAPK14 PIK3R2 PIK3R1 MTOR ITGA6 EIF4EBP1 GRB2 MAPK1 AKT1 GAB1 HRAS MAPK3 SHC1-1 IRS1 ITGB4 PRKCD LAMA5 LAMA2 LAMA1 LAMA3 SOS1 IRS2 RAC1 LAMC2 LAMB3 LAMB1 PRKCA LAMB2 RHOA PTK2 LAMC1 SRC T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260810%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 IFNAR1 PIK3CD TSC2 TSC1 PIK3R1 NFATC1 MTOR MAP2K2;MAP2K1 NFKBIA GRB2 CDKN1A MAPK1 AKT1 RAF1 RPTOR RHEB MYD88 JAK2 HRAS MAPK3 DEPTOR TYK2 RICTOR TNF MLST8 FOS SOS1 IL23R CD3G STAT4 CD3E CD3D IRF2BPL PPP3CC GRAP2 TP53 CTLA4 BAX HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ZAP70 IL23A LCK IL17A LTA LCP2 CARD11 BCL10 FOXO3 ITPR1 RASGRP1 MALT1 FYN RELA CCL19 IL12RB1 JUN PLCG1 ICOS IL12RB2 CD4 PTPRC PRKCQ CD28 IFNB1-4 HLA-DRA CD247 CCL28 GSK3B IL18R1 LAT IKBKB PTEN IKBKG CHUK PDPK1 CDKN2A CCND1 IFNG NFKB1 CD86 CD80 IL12B IL12A BCL2L1 IFNAR2 IL2 IL4 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260810%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway RB1 PLD1 PIK3CD PIK3R3 E2F3 TGFB2 PIK3R2 PIK3CB PIK3R1 MTOR MAP2K2;MAP2K1 BRAF PIK3CA KRAS CDKN1A MAPK1 AKT1 RAF1 DUSP6 PAK3 PAK2 MAPK3 PAK5 PAK4 SMAD4 E2F1 PRKCD RPS6KB1 DDB2 RPS6KB2 TGFBR2 GADD45B GADD45A GADD45G RAC1 CDK6 AKT2 RAD51 AKT3 CDK4 BAD TP53 BAX RALBP1-1 RAC3 RALA-1 RELA MAPK9 MAPK10 TGFBR1-1 PEBP1 BRCA2 CASP9 IKBKB POLK RIPK4 ARHGEF6 IKBKG RALB TGFA PLD2 E2F2 BAK1 RALGDS CHUK CDKN2A EGFR TGFB3 CCND1 MAPK8 ERBB2 TGFB1 EGF VEGFA NFKB1 BUB1B-PAK6;PAK6 SMAD2;SMAD3 JAK1 BCL2L1 STAT1 CDC42 PAK1 STAT3 ARAF STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260810%WP430%HOMO SAPIENS Statin inhibition of cholesterol production MTTP APOA2 LPL DGAT1 LCAT APOA1 LIPC APOC2 APOE APOB LDLR SOAT1 LRP1 APOA4 APOA5 ACSS1 PLTP CYP7A1 FDFT1 PDIA2 ABCG8 ABCG5 APOC3 APOC1 SQLE HMGCR ABCA1 CETP SCARB1 ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260810%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SRC KDR VEGFA RAC1 SLIT2 ROBO4 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260810%WP3965%HOMO SAPIENS Lipid metabolism pathway BCKDHA ACACA PRKAA1 PDHA1 ACSS2 FASN PNPLA2 AKT1 PRKACA-1 ACLY ABHD5 LIPE ACSBG1 PRKACB-1 PLIN1 PRKAG1 PRKAG2 PRKAG3 PRKAR1B PRKAR1A AKT2 AKT3 PRKAA2 PRKAB2 PRKAB1 PRKAR2B PRKAR2A BURN WOUND HEALING%WIKIPATHWAYS_20260810%WP5055%HOMO SAPIENS Burn wound healing TGFB2 SNAI2 FGFR1 BCL2 AKT1 MYD88 CXCL8 PDGFRB TNF MMP9 ICAM1 CASP3 CHRNA7;CHRFAM7A CD3E IL1B ACTA1 TP53 CCL13;CCL2 BAX SERPINH1 TLR4 IFNB1-4 COL1A1 CXCL12 TGFB3 FST HGF ACHE FOXE1 HEXD TNC INHBA F13A1 EGF LGALS1 MMP28 VEGFA TIMP1 KRT6B;KRT6C;KRT6A NFKB1 KRT222 IL15 IL6 DCN SMAD2;SMAD3 SFRP2 S100A6 FGFR2 PECAM1 FBN1 S100A9 CXCR4 SCEL CXCR2 HMGB1-1 S100A11 BRD4 AMBP KLF4 SLURP1 COL1A2 LIN28A MMP1 MMP2 NOX4 TPT1 CXCL2;CXCL3;CXCL1-1 CDK16 FGFR4 FGFR3 DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260810%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens FOXO1-1 CLPP LARS1 SESN2 LONP1 LONP2 ATF4 TSC2 TSC1 TRAP1 MTOR HSPD1 AKT1 GDF15 IRS1 MARS1 PHB MYC OMA1 EIF2A PHB2 SLC7A7 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260810%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism PYY FFAR3;GPR42 FFAR2 GCG SLC2A4 PPARD INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260810%WP453%HOMO SAPIENS Inflammatory response pathway CD28 COL1A1 IL5RA IL2RG THBS3 TNFRSF1B IL5 IL2RA IL2RB CD40 TNFRSF1A LAMA5 VTN IFNG LAMC2 LAMB1 LAMB2 CD86 CD80 FN1 LAMC1 THBS1 ZAP70 IL4R COL3A1 COL1A2 LCK IL2 IL4 CD40LG PURINERGIC SIGNALING%WIKIPATHWAYS_20260810%WP4900%HOMO SAPIENS Purinergic signaling GNAZ LPAR4 PANX1 P2RY8 P2RY6 GNAT2 P2RY4 GNAT3 P2RY2 ADORA3 GNA11 P2RY1 ADORA1 GNAT1 P2RY12 P2RY13 P2RY10 P2RY11 P2RY14 GNAO1 P2RX7 P2RX6 P2RX5 P2RX4 ADORA2A P2RX3 GNAI3 ADORA2B GNAI1 P2RX2 GNAI2 LPAR6 P2RX1 GNAS-1 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260810%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 ACE2 CPN1 PRKG1 MAPK1 VDR NOS3 NPR1 TNF CYP24A1 NFKB1 ROCK1 IL1B KLK1 SERPINE1 IL1A KNG1 RHOA BDKRB2 BDKRB1 NOS1 ACE F12 AGT AGTR1 SERPING1 REN AGTR2 KLKB1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260810%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma AKT1 AKT2 AKT3 MTOR GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260810%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells SLC2A1 GCG IL6R IL6 GLP1R SLC2A2 INS;INS-IGF2 ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260810%WP1993%HOMO SAPIENS Angiogenesis overview ATF2 PLA2G1B PIK3CD MTOR MAP2K2;MAP2K1 FGFR1 GRB2 KRAS MAPK1 AKT1 RAF1 MAP2K6 SHC1-1 ROBO4 MMP9 TEK KDR SOS1 RAC1 PRKCA ELK1 BAD SRC PLXND1 PTK2B SHB ROBO1 TIMP2 TIMP4 PLCG1 FRS2 PTPN11 F2 MAPK14 DOK2 MMP14 CRK APC GRB14-1 GRB7 DAG1 SEMA3A PXN MAPK11 NCK1 WAS SLIT2 FGF1 IQGAP1 VHL SEMA4A ANGPT1 BMX MAP3K7 MAP2K4 PDPK1 NOS3 MAPK8 VEGFA NRP1 MMP2 CDC42 NOX4 PAK1 GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260810%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PRKCG PRKCB PRKCE PRKCQ PKN3 PRKCZ PRKCA NFATC1 PPP3CA ANGPT2 PPP3CC RCAN1 PPP3R1 PPP3CB PLCB3 PRKD3 PRKD2 GNAQ PKN2 PKN1 PRKD1 PRKCI PRKCH PRKCD CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260810%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes HMGCS1-1 SREBF1 LSS IDI1 HSD17B7 CYP7A1 MVK FDFT1 IDI2 MSMO1 CYP46A1 FDPS ACAT2 TM7SF2 EBP MVD FADS2 NSDHL PMVK ACSL1 NR1H2 SC5D CYP51A1 ACOT2;ACOT1 MYLIP CYP27A1 GGPS1 ELOVL3 SCD NR1H3 DHCR24 ACSL3 ELOVL4 PLPP6 CH25H ELOVL2 ABCG1 LBR HMGCR ELOVL5 ABCA1 HMGCS2 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260810%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis CCL4L2;CCL4L1;CCL4 VCAM1 CCL3L1;CCL3L3;CCL3;CCL18 MAPK14 IRAK1 IKBKB NFKB2 IKBKG NFKBIA MAP3K7 TAB2 CHUK TAB1 MYD88 CXCL8 MAPK8 TNF ICAM1 NFKB1 IRAK4 IL6 IL10 ELANE GZMH;GZMB-1 TRAF3 IRF1 LCN2 TRAF6 IL1A IRF7 TLR8 TLR7 IRF5 RELB TLR4 REL RELA MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260810%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCR11 UQCR10 CYC1 UQCC3 UQCC2 UQCC1 UQCRQ BCS1L TTC19 LYRM7 UQCRFS1 UQCRC1 UQCRC2 UQCRB BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260810%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation NOG SMURF1 BMP2 BMPR2 BMPR1A SMAD1 TOB2 BMPR1B TOB1 RUNX2 SMAD4 SMAD6 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260810%WP129%HOMO SAPIENS Matrix metalloproteinases BSG TIMP4 TIMP3 MMP8 MMP10 MMP12 MMP14 MMP11 MMP13 MMP16 MMP15 MMP23B MMP17 MMP19 TNF MMP9 MMP7 MMP28 TIMP1 MMP1 MMP2 MMP3 TCF20 MMP21 MMP20 MMP25 MMP24 MMP27 TIMP2 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP357%HOMO SAPIENS Fatty acid biosynthesis ACACB PC ACACA SCD ACAA2 ACSS2 ACSL3 PECR ECHS1 ECH1 ACSL6 ACSL5 FASN ACSL4 ECHDC1 ECHDC2 ECHDC3 HADH DECR1 MECR ACLY ACSL1 JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260810%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members HDAC2 HDAC3 RBX1 STAT6 STAT1 DTX3L STAT3 CUL1 PARP9 PARP11 BTRC SKP1 PARP1 PARP14 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260810%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX12 POU3F2 POU3F1 H4-16 UTF1 SOX15 H4C1 ZSCAN10 H4C6 FGF4 TEAD2 WWTR1 SOX4 YES1 SOX2 SRRT SOX11 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260810%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation EPHB2 APC GSK3B DVL1 PTEN AKT1 PRKACA-1 WNT3A NTRK1 ABL1 TESK2 TRIO AURKB ROCK1 MAPRE1-1 RAC1 SPRED1 PARD6A DPYSL2 CFL2 STMN1 PRKCA MARK2 CLASP1 CDK1 MARK1 RHO NTRK2 NTRK3 LIMK1 DIAPH1 CLIP1 MAPKAPK2 SRC PTPRA TPPP TAOK1 CAMK4 CDC42 MAP1B GNAQ PAK1 STAT3 KIF2C MAPT PHLDB2 F2RL2 TIAM1 MEVALONATE PATHWAY%WIKIPATHWAYS_20260810%WP3963%HOMO SAPIENS Mevalonate pathway HMGCS1-1 MVK HMGCR FDPS ACAT2 MVD PMVK ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5393%HOMO SAPIENS Androgen biosynthesis CYP11B1;CYP11B2 HSD17B1 HSD17B2 HSD17B4 SRD5A2 HSD17B3 CYP17A1 HSD11B1 HSD11B2 SRD5A1 POR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AKR1D1 HSD3B1;HSD3B2 SULT2A1-4 DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260810%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein ACE AGTR1 ACE2 AGTR2 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260810%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias LBR DHCR24 DHCR7 EBP NSDHL CYP51A1 SC5D MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260810%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response RB1 MRE11 CDKN1B HUS1B BRCA1 PIDD1 CCND3 CCND2 SESN1 CHEK2 CHEK1 TLK2 TLK1 NBN RFC1 SMC1A CDKN1A CDC25C CDC25A CCNE2 RRM2B FANCD2 CCNE1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PRKDC MDM2-2 APAF1 CCNB3 CCNB2 E2F1 ABL1 CASP8 PMAIP1 SFN DDB2 ATRIP GADD45B GADD45A CASP3 CREB1 RPA2 PML GADD45G RAD52 RAD50 CDK6 CYCS-1 RAD51 CDK5 CDK4 BID CDK2 CDK1 RAD17 RAD1 TP53 FAS ATM BAX RAD9A ATR CCNG1 CASP9 CCND1 CCNB1 BBC3 MYC MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260810%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances SLC25A22 SLC25A12 SLC25A13 GLUD1;GLUD2 GOT2-1 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260810%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling RB1 ATF2 MAP2K3 NFE2L2 BCL2 CDKN1A FASLG CCNE1 MAP2K6 MAP3K5 PDGFRA TNF TRAF2 FOS BID TRAF6 ELK1 TP53 FAS BAX JUN CCNA2-1 FGF7 TNFSF10 MAPK14 JUNB TRAF5 HBEGF BMF MAPK12 MCL1 MAPK13 BCL3 MAPK11 HSP90AA1 BAK1 MAP2K4 CDKN2A TNFRSF1A EGFR CCND1 MAPK8 MAP2K7 IFNG IL6 BCL2L1 MMP2 BCL2L11 CFLAR IL2 LUNG FIBROSIS%WIKIPATHWAYS_20260810%WP3624%HOMO SAPIENS Lung fibrosis CCL3L1;CCL3L3;CCL3;CCL18 IL5 NFE2L2 CXCL8 IL13 HMOX1 MECP2 TNF MMP9 CCN2 IL1B CCL13;CCL2 PLAU CCL4L2;CCL4L1;CCL4 FGF7 CCL5 SPP1 SERPINA1 PDGFB FAM13A FGF2 PDGFA FGF1 MT2A CYSLTR2 CCR3 CCR2 DSP EDN1 TGFA ELMOD2 SFTPC CEBPB ATP11A GREM1 CALCA RTEL1 PARN TERT DPP9 STN1 CMA1 MUC5B SMAD7 HGF PTX3 TGFB1 EGF IGF1 TIMP1 IL6 CCL11 IL12B CSF2 CSF3 MMP2 BMP7 CXCL2;CXCL3;CXCL1-1 SKIL IL4 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260810%WP410%HOMO SAPIENS Exercise induced circadian regulation CRY1 MYF6 TUBB3;TUBB6 EIF4G2 IDI1 PIGF CEBPB TAB2 PPP2CB;PPP2CA H2BC15;H2BC3;H2BC11;H2BC12 CBX3-1 NCKAP1 DAZAP2 BTG1 ARNTL GSTP1 AZIN1-2 HERPUD1 PURA HLA-DMA SUMO1 SUMO3 CLOCK UCP3 STBD1 ERC2 SF3A3 HSPA8 GSTM3 RBPMS NCOA4 ZFR G0S2 NR1D2 GFRA1 UGP2 QKI ETV6 TOB1 PER2 PER1 PSMA4 VAPA PPP1R3C DNAJA1-1 KLF9 CLDN5 CRY2 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5380%HOMO SAPIENS 5q35 copy number variation BRCA1 PDLIM7 PIK3R1 PNPLA2 GAB1 PTH ABL1 TPM2 GRIN1 SNCA PLCG1 FGF1 CYP7A1 COX7C ABHD5 COX5A FGFR4 MYC KIAA1191 COX6A1 CAPN3 ARL10 RNF44 UNC5A FBXW7 SLC34A1 MYO7B ADAM10 COX6B1 HIC2 DOK3 EIF4E1B GRB2 GPRIN1 PFN3 MAX MAGED1 BRCC3 DRD2 BARD1 GRK6 PRELID1 PTPRN2 NOP16 GRIN2B HIGD2A MXD3 PRR7 COX7B HIP1 COX4I1 FAF2 CLTB DDX41 BABAM1 SOS1 HK3 BABAM2 UIMC1 NELFB GNAI3 KDM6B GNAI1 COX8A GNAI2 TMED9 EED ARFGAP2 CDHR2 FAM193B CDHR5 B4GALT7 DBN1 SRC F12 RGS14 ABRAXAS1 USH1C NTN1 COX5B NSD1 LMAN2 INPP5D RAB24 ZNF346 H3-3A SNCB HIP1R JUN MAPK9 COX6C SIMC1 FRS2 TSPAN17 ANKS4B PTPN2 MAPK10 TMED10 MAPK8 CXCR4 TMED2-1 IGF1R FGF19 POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260810%WP5485%HOMO SAPIENS Post COVID neuroinflammation TNF TMPRSS2 FURIN IFNG ACE2 IL6 IL10 CCL11 IL1B IL1A HMGB1-1 TLR8 MAPK1 TLR7 IL12A IL18 GFAP TLR4 TLR3 CXCL8 IL2 IL4 BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260810%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation MAPK1 CYP7A1 FXR1-1 ABCG8 SLC10A2 ABCG5 ABCB11 SLC10A1 MAPK3 FGFR4 FGF19 LDLR EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260810%WP167%HOMO SAPIENS Eicosanoid synthesis PTGS2-2 PTGIS PTGES2 ALOX15 ALOX12 PLA2G5 LTC4S PLA2G6 ALOX15B PRXL2B ALOX5AP DPEP1 JMJD7-PLA2G4B;PLA2G4B LTA4H GGT1 PTGDS CBR1-1 TBXAS1 PTGES PLA2G4A PTGS1 ALOX5 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260810%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism A3GALT2 ST3GAL1 ST3GAL2 ST6GALNAC6 B3GALT1 FUT1 ST8SIA1 SLC33A1 ST8SIA3 B3GALT4 ST8SIA5 ST3GAL5 B4GALNT1 SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260810%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD HMGB1-1 THBD AGER CHUK NFKB1 IKBKB RELA NFKBIA IKBKG NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260810%WP438%HOMO SAPIENS Non homologous end joining WRN XRCC6 DCLRE1C XRCC4 POLM PRKDC XRCC5 LIG4 POLL NHEJ1 IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260810%WP2007%HOMO SAPIENS Iron metabolism in placenta HEPHL1 TFR2 IREB2 SLC40A1 ACO1 MCOLN1 HAMP TF STEAP3 SLC11A2 TFRC FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260810%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling PDGFD PDGFC GNG13 LPAR5 CDKN1B CAB39L PRKAA1 HIF3A GNB3 PIK3CD GYS2 GNGT1 TSC2 RAB8A TSC1 PIK3R2 STRADA OSMR PIK3CB PIK3R1 PHLPP2 PHLPP1 MTOR CAB39 MAP2K2;MAP2K1 COL11A1 PIK3CA RELN VEGFB OSM EIF4EBP1 KRAS VEGFC VEGFD MAPK1 AKT1 RAB11B FOXA1 RAF1 CRTC2 EIF4E CSF3R CHRM1 IRS4 FGF3 MDM2-2 MAPK3 IRS1 COMP PDGFRB FGF6 PDGFRA STK11 FGF9 ITGB3 TNN TNR NGF IBSP RAB2A F2R ITGAV PGF COL4A6 LAMA2 PFKFB2 LAMA1 PFKFB1 LAMA3 IRS2 PFKFB4 PFKFB3 LAMC2 EFNA5 LAMB3 AKT2 EFNA4 LAMB1 AKT3 CHAD FGF20 PRKAA2 FGF22 FGF17 EFNA1 FGF16 PTK2 EFNA3 FGF14 EFNA2 GNB2 FGF18 GNB1 GNB4 IL7R FGF13 FGF12 FOXO3 FGF11 HSP90AB1 LAMC3 ELAVL1 VWF PPP2R5B PPP2R5A PPP2R5D TBC1D1 IL3RA EIF4E2 THBS4 GNG2 GNG5 PPP2R3C GNG4 CASP9 GNG8 ANGPT4 RAB10 PIK3IP1 RAB14 HSP90AA1 ITGA8 NOS2 NOS3 LIPE TNC ITGA2B TNXB ITGB5 LAMB2 LAMA4 FN1 LAMC1 EPHA2 THBS2 THBS1 COL3A1 COL1A2 NGFR COL4A2 INSR COL5A1 COL4A1 CREB3L3 COL5A3 ITGA10 CREB3L4 IL2 FGFR4 COL6A2 ITGA11 FGFR3 CREB3L1 ITGAM CREB3L2 COL5A2 FLT4 ITGB2 ITGB6 ITGAE ITGAL ATF2 ITGAX ATF4 ITGB8 ITGB7 ITGA4 SLC2A4 ITGA2 ITGAD IL2RG THBS3 ITGA7 IL2RA ITGA6 IL2RB LPAR4 GRB2 ITGA5 CDKN1A MET RHEB ITGA9 JAK2 JAK3 HRAS ITGB4 TEK PPP2R1B CREB3 KDR SOS1 CREB5 ATF6B NRAS LPAR6 BAD SLC2A2 GHR PPP2R1A EPOR AKT1S1 PPP2R2A;PPP2R2D COL1A1 SREBF1 GSK3B FGF2 IKBKB ANGPT1 IKBKG ANGPT2 FGF21 PDPK1 PPP2CB;PPP2CA PPP2R5E EGF IGF1 PPP2R5C FGFR2 JAK1 PPP2R3A PPP2R2C IL4R PPP2R2B CSF3 IGF1R FGF19 ACACA PPARGC1A COL2A1 COL11A2 FGFR1 ITGB1 FLT1 FOXO1-1 CREB1 HIF1A FGF7 CSF1R CSF1 EPO PDGFB PDGFA FGF1 FGF4 INS;INS-IGF2 ITGA3 FGF8 PRL IL6R COL4A4 EGFR HGF LAMA5 PRLR VTN VEGFA KITLG KIT FGF10 NOS1 IFNAR2 HSP90B1 IFNAR1 PIK3R5 EIF4E1B RPTOR EIF4B RPS6 PIK3CG MLST8 RPS6KB1 RPS6KB2 LPAR1 SPP1 IFNB1-4 PTEN PIK3C2A CHRM2 PIK3C2B PIK3R4 GYS1 SLC2A1 TCL1B TCL1A CDC37 DDIT4 ULK1 EPAS1 LPAR2 LPAR3 GNG10 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260810%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases AKT2 AKT3 MAOB SRPK2 NTRK2 APP CEBPB BACE1 SET-1 AKT1 TARDBP LGMN STAT1 MAPT BDNF SNCA PPP2CB;PPP2CA RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260810%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR PTGS2-2 PIK3CD PIK3CB PTGES2 BRAF PIK3CA ESR1 KRAS MAPK1 AKT1 PTGER4 PTGER1 PTGER2 PTGER3 EGFR HRAS MAPK3 PLA1A PIK3CG AKT2 NRAS AKT3 SRC MMP1 CYP19A1 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260810%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism CRY1 SQSTM1 BHLHE40 SMAD1 SMAD9 SMAD5 CTSK NFATC1 MTOR SP7 BCL2 AKT1 JAK2 SMAD4 PTH TNFRSF11B NPAS2 ARNTL ATG12-1 CLOCK ATG5 PRKAA2 TRAF6 NOTCH1 CSF1 SEMA3A WNT10B TNFSF11 CALCA TNFRSF11A BHLHE41 PIK3C3 RORB ARHGAP4 FYCO1 RB1CC1 WNT5A LAMP2 SOST TGFB1 MAP1LC3B2;MAP1LC3B-1 ATG3 DKK1 SERPINF1 BECN1 MAP1LC3A ATG10 IGF1 MEPE WNT16 BMP4 ATG13 IL3 ATG4C IL6 CTF1 TRAP1 LRP5 CHRD AMBRA1 EFNB2 ATG101 DRAM2 ATG7 HMGB1-1 CTHRC1 SEMA4D BMP6 BMP5 NR1D2 BMP3 BMP2 BMPR2 ATG16L1 LEP PLEKHM1 VCP-1 RUNX2 PER1 ULK1 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5408%HOMO SAPIENS 15q25 copy number variation TENT4B AP3M2 GRM5 BTBD1 C15orf40 FSD2 WHAMM SEC11A PDE8A NMB RYR2 HOMER2 NMBR WDR73 TM6SF1 AP3B2 AP3D1 AP3S2;AP3S1 DNM3 SPCS3 CPEB1 SPCS2 SPCS1 SYNJ1 ALPK3 RAF1 TOP1 SLC28A1 SHANK3 ZSCAN2 SHANK1 HTT EGF GRM1 SLC2A1 AGAP2 RYR1 SH3GL3 RAMAC ZNF592 ITPR1 BNC1 RNMT ADAMTSL3;ADAMTSL1 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260810%WP5049%HOMO SAPIENS Glycolysis in senescence TP53 RB1 PRKAA1 GAPDH-1 HK1 LDHA G6PD PKM PGK1 ALDOC ENO1 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260810%WP5136%HOMO SAPIENS ALA oxylipin metabolism EPHX2 ALOX15 ALOX5 HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260810%WP4540%HOMO SAPIENS Hippo signaling regulation PRKCG PRKCB PRKAA1 CDH10 CDH11 CDH12 MTOR FGFR1 CDH13 FLT1 CDH15 CDH16 MET NF2 MST1 CDH17 CDH19 PRKACA-1 GNA11 PDGFRB PDGFRA NTRK1 PRKACB-1 PRKCD GNAL TEK CDH5 KDR RAC1 PRKAR1A YAP1-1 GNAI3 TEAD1 PRKCA PRKAA2 GNAI2 TEAD2 TEAD3 STK3 TEAD4 RHOA NTRK2 LATS1 WWTR1 PLCB3 PLCB4 LATS2 GNAQ PLCB1 PLCB2 PRKCI PRKCH TCF7L1 PRKCE CSF1R PRKCQ TCF7 PRKCZ PRKD3 EGFR CDH8 CDH6 CDH18 PRKAG1 PRKAG2 PRKAG3 PRKAR1B CDH9 LEF1 SMAD2;SMAD3 CDH7 KIT FGFR2 PRKAB2 CDH4 PRKAB1 GNAS-1 CDH3 TCF7L2 PRKAR2B EPHA2 CDH20 PRKAR2A CDH22 CDH24 CTNNB1 CDC42 NGFR IGF1R INSR CDH2 FGFR4 CDH1 FGFR3 FLT3 FLT4 CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260810%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function PRKCG PRKCB PRKCE MMP8 MMP10 MMP12 MMP14 PRKCQ MMP11 MMP13 MMP16 MMP15 PRKCZ MMP23B MMP17 SNAP25 MMP19 PRKD3 NOS2 PRKCD SCN9A MMP9 TKTL1 MMP7 TRPA1 SORD TRPV1 AGER MMP28 C3-1 SCN10A SCN8A PRKCA SLC2A1 MMP1 MMP2 MMP3 MMP21 MMP20 BDNF MMP25 MMP24 PRKCI MMP27 PRKCH BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260810%WP272%HOMO SAPIENS Blood clotting cascade F2 FGB FGA SERPINB2 F10 F11 SERPINF2 F13B KLK1 FGG SERPINE1 PLAT PLG F3 F5 F7 F12 F8 F9 KLKB1 PLAU VWF P38 MAPK SIGNALING%WIKIPATHWAYS_20260810%WP400%HOMO SAPIENS p38 MAPK signaling MAPK14 ATF2 TGFB2 DDIT3 TGFBR1-1 RIPK1 MKNK1 HSPB1 MAP3K7 GRB2 MAX MAP2K4 MAP2K6 RPS6KA5 MAP3K5 HRAS SHC1-1 TRADD DAXX MAP3K1 TRAF2 CREB1 SMIM40 RAC1 ELK1 MAP3K9 MAPKAPK2 RASGRF1 STAT1 CDC42 MEF2D HMGN1 MAPKAPK5 PLA2G4A MYC SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260810%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 KDR FURIN VEGFA ACE2 NRP1 CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260810%WP3594%HOMO SAPIENS Circadian rhythm genes BHLHE40 PRKAA1 GFPT1 PHLPP1 CHRM1 PRKDC PPARA AVP PML NONO DDC CDK4 PRKAA2 GNAQ MTTP HNF1B NOS2 BHLHE41 RORB PPP1CB PPP1CC RELB LEP NGFR EP300 PRKCG ATF4 HDAC2 HDAC3 AHCY EGR3 HDAC1 TYMS TOP1 GNA11 ADORA1 NTRK1 ADORA2A SERPINE1 TP53 FAS F7 PRF1 HNRNPU CCAR2 PROK2 PROK1 UTS2R JUN METTL3 SOX14 CSNK1D CLDN4 ATF5 PPP1CA DHX9 SREBF1 NKX2-1 JUND HOMER1 GSK3B NR1D1 NR2F6 SETX NMS ID4 HNRNPD ID3 FBXL3 ADA ID2-1 EZH2 SUV39H2 SUV39H1 PRMT5 NCOA2 KCND2 PAX4 PROX1 MC3R NCOR1 TPTEP2-CSNK1E;CSNK1E MAPK8 KCNMA1 CIPC ARNTL2 CST3 NPS PROKR1 PROKR2 NFIL3 NR1H3 SIK1;SIK1B ARNT2 CAVIN3 MYBBP1A GHRH GHRL AGRP LGR4 CRTC1 NPY2R RORC UBE3A AHR NAGLU KCNH7 USP2 ADIPOQ DYRK1A CARTPT MTNR1A OGT-1 MTNR1B PSPC1 TIMELESS DDX5 MAGEL2 CPT1A KMT2A RAI1 DRD1 DRD3 DRD4 ZFHX3 OPN4 PPARGC1A OPN3 BTBD9 RBM4;RBM4B KDM5A HEBP1 DBP SIN3A SIX3 SFPQ-1 KLF10 ARNT THRAP3 CRH ROCK2 CRX OPRL1 CIART ATOH7 MTA1 CUL1 NOCT NRIP1 HCRTR2 BTRC HS3ST2 SKP1 HCRTR1 NPAS2 ARNTL ADCY1 CREB1 CLOCK NTRK3 NLGN1 UBA52 RPS27A SFTPC UBB;UBC TNFRSF11A IL6 TPH2 NR1D2 SLC6A4 PER2 PER1 KLF9 CRY2 CRY1 MAGED1 DRD2 PRKG2 SIRT1 NAMPT TOP2A MAPK9 MAPK10 PTEN FBXW11 RORA PTGDS AANAT TH CHRNB2 SLC9A3 TPH1 PPARG EGR1 CREM HTR7 STAR IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260810%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia BCR PIM1 LYL1 SPRED2 CSF1R GADD45A SKP2 CDKN1B KIT FLT1 ABCG2 PDGFRB FOXO3 PDGFRA MYC PIM2 ABCB1 NOP2 ABL1 GAB2 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260810%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome RB1 CCND2 MSX1 FSHB EIF4E MDM2-2 E2F1 NGF NUP62 PCSK1 CYFIP1 AHCTF1 NUP188 FMR1 GABRR3 CDK6 GLE1 GABRR2 GABRR1 CDK4 HERC2 BBS4 NDC1 NUP214 SNRPN TP53 NUP210 NUP133 NUP107 NIPA1 CGA TACR3 NIPA2 NUP93 NUP50 FEZ1 FEZ2 SNURF NUP54 NUP98 OCA2 NUP205 SLC45A2 SEH1L NUP58-2 TUBGCP2 LHB RNF8 SEC13 ATP10A AAAS NUP160 PRKCZ NHLH2 NUP42 NUP85 TPR GABRB3 INS;INS-IGF2 NDN NUP43 NUP88 RAE1 RANBP2 NUP155 NUP153 CDKN2B CDC6 GABRG3;GABRG2 CDKN2C TYR OXT-1 CDKN2A KISS1 GABRD POMC TUBGCP5 UBE2N CCND1 NUP35 MKRN3 GNRH1 TUBGCP6 MDM4 TUBGCP3 TUBGCP4 GABRA5 NUP37 GABRG1 GHRH GHRL UBE3A DLX5 POM121;POM121C BDNF MAGEL2 INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260810%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNC2H1 DYNC2I2 DYNC2I1 DYNC1H1 DYNC1I2 DYNLT1 IFT140 DYNLT2B WDR19 IFT122 IFT80 WDR35 HSPB11 DYNC2LI1 DYNC1LI1 IFT22 DYNC1LI2 IFT43 IFT81 IFT27 DYNLRB2 DYNLRB1 IFT46 DYNC1I1 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260810%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis FGF8 TBX6 NOTCH1 WNT3A HES7 LFNG MESP2 EPHA4 HES1 DLL1 RIPPLY2 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260810%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer SERBP1-1 IER3 VAV3 SQSTM1 HELLS CDKN1B ANXA5 SOCS3 TRAF1 ERN1 CARD14 TNFRSF21 BEX3 CUL5 HDAC1 RNF7 NQO1 NET1 GCLC HSPB1 CDKN1A MAPK1 AKT1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CUL1 CTNNA1 VIM PAK2 ABL1 TNF RPS6KB1 F2R BIRC5 HSPD1 PTK2 IL7R PKN1 YBX3 PTK2B JUND BCL3 APOE CASP7 APP RIPK2 NRG1 ERBB3 SMAD7 AXIN1 NFKB1 ETS1 THBS1 HSPA5 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260810%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF2S2 EIF2S3;EIF2S3B EIF2S1 EIF1 EIF3C;EIF3CL EIF5 EIF1AY;EIF1AX EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260810%WP325%HOMO SAPIENS Triacylglyceride synthesis AGPAT1 AGPAT2 DGAT1 LPL AGPAT3 GK2 MOGAT3 LIPF AGPAT5-1 LIPC PLPP3 PLPP2 AGPAT4 PLPP1 GK GPAM GNPAT GPD1 AGPS PNPLA2 LIPE DGAT2 MOGAT2 MOGAT1 EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260810%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation NLRP3 PRKAR1B PRKAR2A PRKAR1A NEK7 RAPGEF3 IL1B PRKACB-1 METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260810%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway MAT2B TAT AHCY AMD1 ODC1 MTR-1 APIP MRI1 TXN SRM IL4I1 MSRA MTAP BHMT ADI1 MAT1A CHDH SMS MSRB2 MSRB3 ENOPH1 MAT2A INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260810%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB TIFA AJUBA SQSTM1 IRAK1 NFKB1 PRKCZ UBE2N UBE2V1 TRAF6 IL1A 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260810%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome ACTR1A ACTR1B PLAGL1 KIAA0753 MYH11 BMERB1 DCP2-1 DISC1 OFD1-1 ABCC1 NDE1 ABCC6 PLK1 MARF1 DCP1A CEP20 ACTR10 RAPGEF4 PAFAH1B1 GATA3 RAP1A DCTN6 DCTN1 PLAG1 DCTN4 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome CCL5 MTMR10 CHRNA7;CHRFAM7A KLF13 OTUD7A GPR75 TRPM1 GRM6 FANCD2 FAN1 SERPINH1 KAT2B CREBBP FYN CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260810%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis PLCG1 CD4 NFATC2 HDAC2 CALM1 HDAC1 NR4A1 PPP3CA PPP3CC PPP3CB ZAP70 LCK ITPRIP MEF2D ATP2A1 CABIN1 CD8A CD8B;CD8B2 CAPN2 EP300 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260810%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation CDKN1B DGKZ CUL5 PIK3R2 RNF7 PIK3R1 NFKBIA GRB2 AKT1 TNFAIP3 CD3G CD3E CD3D TRAF6 GRAP2 ZAP70 GNA13 LCK MEF2D LCP2 CARD11 BCL10 MALT1 RELA PLCG1 PRKCQ CD28 CD247 LAT PTPN6 IKBKB IKBKG MAP4K1 CHUK PDPK1 CD8A ITK SMARCB1 DGKA CBLB TMEM222 ARIH2 ELOB UBASH3A RHOH RASA2 NFKB1 AGO3;AGO1 NDUFB10 ZFP36L1 PCBP2 MAP3K14 RPRD1B SH2B3 SH2D1A FIBP CD5 SOCS1 MAP3K8 VAV1 REL CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260810%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide TGFB1 CD28 IFNG IL10 IL5 CD86 CD80 VIP FAS CTLA4 IL12A IL2 IL4 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260810%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome PPP2R5B STAG2 PPP2R5A ESPL1 PPP2R5D STAG3 APC PLK1 HDAC8 SMC1A PPP2CB;PPP2CA PPP2R5E PPP2R1B PPP2R5C AURKB CDK1 CDCA5 PDS5B SMC3 PDS5A NIPBL RAD21 PTTG1;PTTG2 ESCO1 ESCO2 PTPA REC8 WAPL SMC1B PPP2R1A SGO1 SGO2 MAU2 FRAGILE X SYNDROME%WIKIPATHWAYS_20260810%WP4549%HOMO SAPIENS Fragile X syndrome CYFIP2 SLC16A1 GRIP1 SYNGAP1 SH3GL1 TSC2 DICER1 TSC1 GRIP2 EEF1A1 ALDH3A2 PIK3CB ARC TBC1D7;TBC1D7-LOC100130357 MTOR HOXB8 MAP2K2;MAP2K1 TELO2 GRIA1 MKNK1 GRIA2 RAP1GAP KRAS GRIN2A CLTCL1 MAPK1 AKT1 EIF4EBP2 RAF1 ARHGAP32 GAB1 DLG4 EIF4E AGO2 NF1 ABCD3 KCNC1 SHC1-1 CLTC TECR DEPTOR CLTA DLGAP3 MECP2 DUSP3 DNM2 TTI1 PICK1 AKAP5 CREB1 CNR1 CYFIP1 EPS8L1 TARBP2 CAMK1 FMR1 PTPN5 HCN1 NTRK2 GRIN1 CAMK4 MAP1B PLCB1 ITPR1 PLCG1 PPP2R5B DAG1 GABRB2 ABAT APP AP2A1 SLC6A1 GPHN DNM1 GABRG3;GABRG2 AP2S1 CDKN2A GABRD AP2M1 GABRA1 CAMK2B MAP1LC3B2;MAP1LC3B-1 GAD1 GRM1 AP2B1 EIF4G1 ARAF SH3GL3 EPHA4 GRM5 BRAF ALDH5A1 GRB2 EIF4A1 RPTOR RHEB PRKACA-1 SHANK1 CAMK2A GRIN2B MLST8 MMP9 RPS6KB1 CLTB SOS1 PRKAR1A PRKCA SRC AGAP2 FYN AKT1S1 PTPN11 PDK1 PPP1CA HOMER1 PTEN PPP3CA KCND2 BDNF CPT1A PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation CLIP1 TUBA1A DYNC1H1 PAFAH1B1 NUDC DCX VLDLR PAFAH1B3 PAFAH1B2 RELN NDEL1 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260810%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260810%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects PIK3CD PIK3R3 PIK3R2 PIK3CB PIK3R1 MTOR MAP2K2;MAP2K1 PIK3CA KRAS GRIN2A MAPK1 AKT1 GAPDH-1 RAF1 IRS4 MAP3K5 MAPK3 IRS1 SLC25A4 IRS2 AKT2 CHRNA7;CHRFAM7A AKT3 CDK5 CALML6 PPP3CC CALML3 CALML4 PSMD8 PSMD9 PLCB3 PSMD6 PLCB4 GRIN1 FRAT2 PSMD7 GNAQ PSMD4 PSMD2 PSMD3 PLCB1 PSMD1 PLCB2 CSNK2A2 ITPR1 ATG14 PSMC2-1 DKK2 DKK4 SFRP4 CSNK2B LPL ULK2 VDAC1 APH1A NCSTN APH1B NRBF2 APOE GRIN2C GRIN2D ATG2A CASP9 NOX1 ATG2B CASP7 IDE RYR3 TUBA1C APP PSENEN APC2 BACE1 PSMA5 EIF2AK2 PSMA6 PSMA3 PSMA1 NOS2 PSMA7 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RB1CC1 APBB1 CSNK1A1 TUBB4B PSMA2-1 PSMC5 BECN1 PSMC6 PSMC3 ATG13 PSMC4 PSMC1 CDK5R1 VDAC2-1 KIF5C AMBRA1 KIF5A TUBB1 ATG101 CALM3;CALM1 CAPN1 TUBA4A ADAM17 PPIF CALM2 PPID RTN3 PSMD12 PSMD14 CTNNB1 PSMD13 NOX4 PSEN2 INSR ITPR2 ARAF CACNA1D GPR83 ITPR3 CACNA1C PSEN1 CACNA1F KLC1 KLC4 PTGS2-2 KLC3 KLC2 VDAC3 NAE1 ATF4 CACNA1S TUBA3E;TUBA3C-1 SEM1 TUBB4A;TUBB;TUBB8B;TUBB8 MCU TUBA8 ATP2A3 TUBB2B;TUBB2A WIPI1 BRAF WIPI2 SLC25A5 LRP1 SLC25A6 TUBAL3 BECN2 HSD17B10 ADRM1 SLC25A31 HRAS APAF1 TNF CASP3 CYCS-1 NRAS BID IL1A BAD FAS FZD10 WNT5B GSK3B WNT6 DVL1 IKBKB DVL2 PPP3CA DVL3 WNT3 WNT4 FZD1 WNT10B PPP3R1 WNT10A FZD3 PPP3CB FZD2 FZD7 FZD6 CHUK FZD9 TNFRSF1A TPTEP2-CSNK1E;CSNK1E MAPK8 MAP2K7 AXIN1 AXIN2 NFKB1 WNT16 CALM1 LRP5 LRP6 WNT11 WNT7A FZD5 FZD8 KIF5B MAPT SNCA WNT2B CSF1 INS;INS-IGF2 MME WNT1 WNT2 WNT3A WNT7B WNT5A DKK1 IL6 NOS1 PSMA4 XBP1 EIF2AK3 TUBB3;TUBB6 CYBB ERN1 DDIT3 FADD ATF6 ADAM10 EIF2S1 GRIN2B CASP8 TRAF2 CSNK2A1;CSNK2A3 IL1B RELA MAPK9 APC MAPK10 ATP2A1 PIK3C3 CAPN2 RTN4 PIK3R4 AGER ATP2A2 TUBA1A ULK1 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260810%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways FZD5 FZD4 MAP2K3 FZD8 PIK3CD SMAD1 SMAD9 PIK3R2 SMAD5 MTOR FGFR1 MAP2K2;MAP2K1 MAPK1 AKT1 RAF1 BMPR1A GAB1 MAP2K6 FGF3 MDM2-2 PDGFRB FGF6 PDGFRA SMAD4 FGF9 ACVR2B FGF23 AKT2 AKT3 FGF20 FGF22 FGF17 ELK1 FGF16 FGF14 FGF18 FGF13 FGF12 FGF11 FGF7 WNT2B PDGFB PDGFA FGF1 FGF4 FGF8 WNT1 WNT2 EGFR WNT3A WNT7B SMAD7 WNT5A NOG BMP4 FGF10 CTNNB1 ARAF FGFR4 FGFR3 BRAF SMAD6 GRB2 FGF5 ACVR1 LIFR HNF1A SELENOP LIF HRAS ACTR2 ERAS FOS SOS1 MAPK6 MAPK4 JUN WNT5B PTPN11 APC MAPK12 GSK3B FGF2 WNT6 DVL1 DVL2 DVL3 PTEN WNT3 WNT4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD7 IL6ST FZD6 FGF21 FZD9 MAPK7 MAP2K5 AXIN1 WNT9B EGF WNT16 LRP5 FGFR2 LRP6 WNT11 WNT7A JAK1 BMPR2 BMPR1B STAT3 FGF19 GPCRS OTHER%WIKIPATHWAYS_20260810%WP117%HOMO SAPIENS GPCRs other DRD3 DRD4 HTR2A GHRHR FSHR ADORA3 ADGRL2 ADRB2 ADGRL3 CHRM3 OR2M4 ADRA1D P2RY13 GPR61 GPR62 SSTR2 P2RY11 CELSR1 F2R GRPR OR7E24-1 CNR1 RXFP1 CELSR3 RXFP3 GPR132 ADORA2A EDNRA GPR176 OR2B6;OR2B2-1 ADGRE3 GNRHR CCR5 ALG6 GPR135 S1PR1 ADGRV1 OR8G1;OR8G5 OR1F1 OR2H1-1 TAAR5 OR1J2 TAAR2 OR1N1 GPR162 CCKBR SMO LTB4R2 ADGRF5 OR1E1;OR1E2 VN1R1 UTS2R OR6C3 OR10A5 OR3A1 PTGFR C5AR2 GPR88 OR2A7;LOC107987545;OR2A4 GPR84 MCHR2 ADGRG1 CXCR3 HRH4 OR6C2;OR6C68 OR5AC2-2 NTSR1 CCR2 GPR17 HTR1F CHRM2 OR2F1-2 GPR55 ADGRD1 CXCR1 GPR143 GPR183 ACKR1 LGR6 OR2A5 GPR18 CELSR2 PROKR2 GRM1 CXCR2 HTR7 GPR83 NEUROINFLAMMATION%WIKIPATHWAYS_20260810%WP4919%HOMO SAPIENS Neuroinflammation MAPK14 CHUK NOS2 FOS TLR4 ASCC1 MAPK8 MTOR RELA NFKBIA JUN VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260810%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression GRM5 GRIN2C GRIN2D GCLC NFE2L2 BCL2 GRIN2A GGT1 VDR CHRM1 KDM3A KDM1A G6PD KDM1B GRIN2B SLC8A1 CALB1 GSR ATP2B4 ATP2B3 CYP27A1 ATP2B2 CYP27B1 ATP2B1 RXRA KCNQ2 KCNQ3 TPH1 PVALB KDM6B TPH2 GRIN1 ITPR2 ITPR3 ITPR1 CACNA1C ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260810%WP4707%HOMO SAPIENS Aspirin and miRNAs PTGS2-2 PDK1 ABCC4 WNT1 VEGFA NFKB1 NOS3 PPARA PTGS1 MVD IL7 SIGNALING%WIKIPATHWAYS_20260810%WP205%HOMO SAPIENS IL7 signaling STAT5A STAT5B IL7 GSK3B PIK3R2 IL2RG PIK3R1 MAP2K2;MAP2K1 BAD MAPK1 JAK1 AKT1 STAT1 STAT3 IL7R JAK3 MAPK3 PTK2B FYN RAS SIGNALING%WIKIPATHWAYS_20260810%WP4223%HOMO SAPIENS Ras signaling RGL2 RASGRF2 GNG13 RASA4;RASA4B PLA2G4F PLA2G1B PLD1 PLA2G12A SYNGAP1 GNB3 PIK3CD PLA2G12B PIK3R3 KSR1 GNGT1 PLA2G4D PLA2G4E PIK3R2 RRAS2 PIK3CB PLAAT3 PIK3R1 KSR2 MRAS FGFR1 RASA3 MAP2K2;MAP2K1 PIK3CA RAPGEF5 FLT1 ARF6 SHOC2 PLA2G10;LOC100652777 KRAS GRIN2A PLA2G2F MAPK1 PLA2G2D AKT1 PLA2G2E RAF1 GAB1 PLA2G2C NF1 MAPK3 SHC1-1 PDGFRB PDGFRA ABL1 GAB2 AKT2 AKT3 ELK1 CALML6 RHOA NTRK2 CALML3 RAP1B CALML4 RAP1A GNB2 ZAP70 GRIN1 GNB1 GNB4 RASGRP1 PLCG2 PLCE1 PLCG1 CSF1R GNG2 GNG5 LAT GNG4 GNG8 RALB PLD2 RALGDS EGFR PLA1A BUB1B-PAK6;PAK6 KIT CALM3;CALM1 CALM2 EPHA2 AFDN BCL2L1 NGFR CDC42 INSR PAK1 PLA2G4A FGFR4 FGFR3 TIAM1 REL FLT3 RASA1 FLT4 PRKCG PRKCB GRB2 MET FASLG PRKACA-1 PAK3 HRAS PAK2 PAK5 GRIN2B PAK4 NTRK1 PRKACB-1 TEK KDR SOS1 RAC1 SOS2 NRAS PRKCA STK4 BAD RASGRF1 RALBP1-1 RAC3 RALA-1 EXOC2 RELA MAPK9 PTPN11 MAPK10 PLA2G2A-1 IKBKB PLA2G5 PLA2G6 IKBKG JMJD7-PLA2G4B;PLA2G4B CHUK MAPK8 NFKB1 RASA2 ETS1 ETS2 RASSF1 CALM1 RASSF5 RIN1 FGFR2 SHC4 RAB5B SHC2 SHC3 RAB5C PLA2G3 HTR7 RASAL1 FOXO4 RASAL2 RASAL3 RASGRP2 RASGRP4 IGF1R TTBK1 RASGRP3 RRAS ABL2 BRAP GNB5 RGL1 GNG10 RAB5A MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260810%WP2857%HOMO SAPIENS Mesodermal commitment pathway FZD5 PBX1 TCF4 FZD4 ACACA BHLHE40 FZD8 SMAD1 ZFHX4 SESN1 HAND1 FGFR1 DLL1 TBX6 FOXA1 BMPR1A SOX21 SOX17 TRIM28 CUL4B CEP250 DIP2A RPL38 PITX2 SMAD4 EOMES WDHD1 ZNF281 FOXH1 ARID5B EMSY ACVR2B PIAS1 ADAM19 TWSG1 WDFY2 HPRT1 BCORL1 TOX YAP1-1 MACF1 MBTD1 EPB41L5 TEAD1 PAX6 UBR5 TEAD2 ATP8B2 PBX3 HMGA2 GDF3 TOX3 TRERF1 EXT1 LATS1 CCDC88A EXT2 NABP2 TRIM71 IQCJ-SCHIP1;SCHIP1 SETD2 RARG NCAPG2 PHF6 CSRP2 ZIC2 ZIC3 TRIM5 TCF7L1 C1QBP HNF4A DNMT3B JARID2 AMH FOXC2 KDM6A FOXC1 SLC2A12 MSGN1 TET1 PARP8 ARL4A DDAH1 AEBP2 FOXA2 MTF2 RARB AHDC1 C9orf72 WDCP FGF8 ASCC3 TBX1 ZNF462 ELP4 GRHL2 ACVR2A TBX3 MEIS1 WNT3A KLF5 CCND1 RGS10 CCDC6 LEFTY2;LEFTY1 MIXL1 NOG INHBA DKK1 HTT BMP4 CHRD NODAL KLF4 HES7 VAV3 SMAD6 NFE2L2 ACVR1 PRKACA-1 JAK2 PRKAR1A CTBP2 POU5F1;POU5F1B WNT3 NANOG;NANOGP8 SOX2 PPP2CB;PPP2CA AXIN1 AXIN2 SMAD2;SMAD3 PLCH1 LEF1 CRTC1 GATA6 SRF GATA3 ELK4 NLK BMPR2 BMP7 SNAI1 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2881%HOMO SAPIENS Estrogen receptor pathway PDK4 PCK1 NR0B2 GPAM SP1 ESR1 STAT3 PPARA CYP1A1 CYP1B1 ACOX1 JUN CYP1A2 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260810%WP5120%HOMO SAPIENS Inclusion body myositis PSENEN APP BACE1 NCSTN NFKB1 PSEN2 MAPT MSTN SIRT1 PSEN1 NFKB2 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260810%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways CHKB ETNK2 PCYT1A CTH SARDH GCLM PLD1 CDO1 AHCY MTR-1 GCLC ETNK1 TYMS PEMT CHPT1 BCAT2 MTHFR MAT1A DHFR2;DHFR BHMT CHDH PHGDH PSPH PSAT1 ALDH7A1 DNMT3B CEPT1 DNM1 MAT2A GSR MAT2B DMGDH AHCYL2 GAD1 AHCYL1 CSAD SLC25A48 GAD2 DNMT3L CBS;CBSL PCYT1B GPX1 GPX4 BHMT2 GPX6 GPX5 DNMT3A AMT GPX7 BAAT MTHFD1 MTHFD2 MTHFD2L BCAT1 SHMT2 SHMT1 MTHFD1L CHKA AGXT2 GSS SOD3 GNMT PCYT2 SOD1 ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260810%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome LMNB2 LMNB1 FNTA CFD C3-1 C5 LMNA RCE1 CFB ICMT 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5400%HOMO SAPIENS 6q16 copy number variation GHSR MC4R GHRL NPY AGRP LEPR INS;INS-IGF2 SIM1 ARNT NTRK2 LEP INSR POMC BDNF CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260810%WP5603%HOMO SAPIENS Caffeine in myocytes MYH11 RYR2 MYH13 RYR3 MYLPF MYH1 MYL6 MYH7 ACTC1;ACTG2 ACTG1 TNNI1 TNNI2 TNNI3 TPM3 TPM4 TNNC1 TPM2 TPM1 TNNC2 ACTA1 MYH3 MYL1 TNNT1 TNNT2 MYL2 ACTB-1 MYL3 TNNT3 MYH8 MYH6 RYR1 ACTA2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2406%HOMO SAPIENS Cardiac progenitor differentiation MESP1 MYLK3 SOX1 SCN5A ZFP42 SOX17 GATA4 SIRPA;SIRPB1;SIRPG THY1 TBXT TBX20 ACTC1;ACTG2 PDGFRA NCAM1 NKX2-5 IRX4 IGF2 TNNI3 TBX5 KDR PAX6 TNNT2 MYL2 MYH6 BMP1 MAPK14 NOTCH1 GSK3B POU5F1;POU5F1B FGF2 ANPEP FOXA2 INS;INS-IGF2 NRG1 WNT3A NANOG;NANOGP8 MEF2C SOX2 MIXL1 NOG TGFB1 INHBA DKK1 IGF1 BMP4 ROR2 KIT NODAL CXCR4 ISL1 LIN28A LIN28B MESP2 MAPK CASCADE%WIKIPATHWAYS_20260810%WP422%HOMO SAPIENS MAPK cascade MAPK14 MAP2K3 MAPK12 MAPK10 MAP2K2;MAP2K1 BRAF RASA3 GRB2 KRAS MAPK1 MAP2K4 RAF1 MAP2K6 HRAS MAPK3 MAP2K7 MAP3K2 MAP3K3 MAP3K1 LAMTOR3 SIPA1 SOS1 SOS2 NRAS ELK1 MAP2 PLCB3 MBP ARAF RRAS JUN MAP3K12 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260810%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease SOCS3 PRKAA1 PIK3CD PIK3R3 PIK3R2 PIK3CB PIK3R1 PIK3CA AKT1 MAP3K11 MAP3K5 PPARA IRS1 IRS2 AKT2 AKT3 PRKAA2 NDUFA13 INS;INS-IGF2 CASP7 CEBPA BAK1 COX7C IL6R UQCRFS1 NDUFS8 UQCRC1 NDUFS3 UQCRC2 SMAD7 UQCRB UQCR11 PRKAG1 UQCR10 PRKAG2 COX5A CYC1 PRKAG3 NDUFV1 IL6 NDUFA9 NDUFA4 PRKAB2 PRKAB1 UQCRQ LEP CDC42 INSR BBC3 BCL2L11 COX4I2 XBP1 EIF2AK3 ATF4 COX6A1 ERN1 DDIT3 LEPR COX6B1 EIF2S1 FASLG CXCL8 CYP2E1 CASP8 TNF COX7B COX4I1 TRAF2 CASP3 RXRA NDUFA11 NDUFA12 NDUFA10 RAC1 COX6A2 SDHC SDHD CYCS-1 COX6B2 SDHA COX8A SDHB IL1B BID NDUFB11 COX7A2 IL1A ADIPOR1 NDUFC2;NDUFC2-KCTD14 FAS CCL13;CCL2 NDUFV3 BAX NDUFV2 COX7B2 NDUFS5-1 MLX COX8C NDUFC1 COX5B NDUFS7 NDUFS6 NDUFS4 NDUFS2 NDUFS1 NDUFB9 RELA JUN NDUFB8 MAPK9 COX6C VCAM1 NDUFB7 GSK3A NDUFB6 COX7A2L-1 NDUFB5 NDUFB4 SREBF1 NDUFB3 NDUFB2 NDUFA4L2 GSK3B NDUFB1 MLXIP NDUFA8 NDUFA7 IKBKB NDUFA6 NDUFA5 PKLR NDUFA3 NR1H4 ITCH NDUFAB1 TNFRSF1A ADIPOR2 MAPK8 TGFB1 NR1H3 NFKB1 NDUFB10 ADIPOQ PROTEASOME DEGRADATION%WIKIPATHWAYS_20260810%WP183%HOMO SAPIENS Proteasome degradation NEDD4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 UBE2D1 PSMD2 PSMD3 PSMD1 PSMC2-1 H2AC4 H2AZ2;H2AZ1 UBB;UBC UBE2D3-1 PSMA5 UCHL1 PSMA6 PSMD5 PSMA3 UCHL3 PSMA1 PSME3 PSMA7 PSME1 PSME2 PSMB6 PSMD10 PSMB7 PSMD11 PSMB4 RPN2 PSMB5 UBA7 PSMB2 RPN1 PSMB3 PSMB10 PSMB1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E UBE2B UBE2D3;UBE2D2 PSMB8 PSMA2-1 PSMB9 PSMC5 PSMC6 UBA1 IFNG PSMC3 PSMC4 PSMC1 PSMD12 PSMD13 PSMA4 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260810%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 FOCAL ADHESION%WIKIPATHWAYS_20260810%WP306%HOMO SAPIENS Focal adhesion PDGFD CAV2 PDGFC TNK2 TNK1 FGR PPP1R12B PIK3CD DOCK1 PIK3R3 PPP1R12C STYK1 CCND3 BCAR1 PIK3R2 CCND2 PIK3CB PIK3R1 MAP2K2;MAP2K1 PIK3CA RELN VEGFB VEGFC VEGFD MAPK1 AKT1 RAF1 MAPK3 COMP PDGFRB PDGFRA ITGB3 TNN TNR IBSP ITGAV PGF COL4A6 LAMA2 LAMA1 LAMA3 ROCK1 LAMC2 LAMB3 AKT2 LAMB1 AKT3 CHAD ELK1 RHOA PTK2 RAP1B RAP1A LAMC3 VWF XIAP THBS4 ITGA8 TNC BUB1B-PAK6;PAK6 ITGA2B TNXB PPP1CB ITGB5 LAMB2 PPP1CC LAMA4 ITGA1 FN1 LAMC1 THBS2 THBS1 COL1A2 CTNNB1 COL4A2 COL4A1 COL5A3 ITGA10 COL6A2 ITGA11 COL5A2 BIRC2 PRKCG ITGB6 BIRC3 PRKCB ITGB8 ITGB7 PPP1R12A ITGA4 ITGA2 THBS3 BRAF ITGA7 ITGA6 BCL2 GRB2 ITGA5 MET ITGA9 PAK3 HRAS PAK2 PAK4 ITGB4 KDR SOS1 RAC1 PRKCA BAD SRC RASGRF1 RAC3 FYN JUN PPP1CA COL1A1 CRK GSK3B PXN PDPK1 MAPK8 EGF IGF1 SHC4 SHC2 SHC3 IGF1R CRKL COL2A1 ITGB1 FLT1 ROCK2 SHC1-1 ACTG1 TESK2 DIAPH1 MYL2 ILK PDGFB PDGFA ITGA3 ACTN4 COL4A4 EGFR CCND1 HGF ERBB2 TLN1 VCL CAV1 LAMA5 VTN VEGFA PARVA ACTB-1 CDC42 PAK1 VAV1 VAV2 VAV3 MYLPF MYLK3 MAPK9 SPP1 MAPK10 PTEN CAPN2 MYLK ACTN1 PIP5K1C MYL5 MYL7 TLN2 TXK MYL12A MYL12B MYL10 VASP SRMS PTK6 PARVB PARVG ARHGAP5 EMP2 HCK RAPGEF1 FLNA FLNB FLNC ZYX CAV3 MYLK2 ARHGAP35 MYLK4 BLK ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260810%WP5124%HOMO SAPIENS Alzheimer 39 s disease PIK3CD PIK3R3 PIK3R2 PIK3CB PIK3R1 MTOR MAP2K2;MAP2K1 PIK3CA KRAS GRIN2A MAPK1 AKT1 GAPDH-1 RAF1 IRS4 MAP3K5 MAPK3 IRS1 SLC25A4 IRS2 AKT2 CHRNA7;CHRFAM7A AKT3 CDK5 CALML6 PPP3CC CALML3 CALML4 PSMD8 PSMD9 PLCB3 PSMD6 PLCB4 GRIN1 FRAT2 PSMD7 GNAQ PSMD4 PSMD2 PSMD3 PLCB1 PSMD1 PLCB2 CSNK2A2 ITPR1 ATG14 PSMC2-1 DKK2 DKK4 SFRP4 CSNK2B LPL ULK2 VDAC1 APH1A NCSTN APH1B NRBF2 APOE GRIN2C GRIN2D ATG2A CASP9 NOX1 ATG2B CASP7 IDE RYR3 TUBA1C APP PSENEN APC2 BACE1 PSMA5 EIF2AK2 PSMA6 PSMA3 PSMA1 NOS2 PSMA7 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 RB1CC1 APBB1 CSNK1A1 TUBB4B PSMA2-1 PSMC5 BECN1 PSMC6 PSMC3 ATG13 PSMC4 PSMC1 CDK5R1 VDAC2-1 KIF5C AMBRA1 KIF5A TUBB1 ATG101 CALM3;CALM1 CAPN1 TUBA4A ADAM17 PPIF CALM2 PPID RTN3 PSMD12 PSMD14 CTNNB1 PSMD13 NOX4 PSEN2 INSR ITPR2 ARAF CACNA1D GPR83 ITPR3 CACNA1C PSEN1 CACNA1F KLC1 KLC4 PTGS2-2 KLC3 KLC2 VDAC3 NAE1 ATF4 CACNA1S TUBA3E;TUBA3C-1 SEM1 TUBB4A;TUBB;TUBB8B;TUBB8 MCU TUBA8 ATP2A3 TUBB2B;TUBB2A WIPI1 BRAF WIPI2 SLC25A5 LRP1 SLC25A6 TUBAL3 BECN2 HSD17B10 ADRM1 SLC25A31 HRAS APAF1 TNF CASP3 CYCS-1 NRAS BID IL1A BAD FAS FZD10 WNT5B GSK3B WNT6 DVL1 IKBKB DVL2 PPP3CA DVL3 WNT3 WNT4 FZD1 WNT10B PPP3R1 WNT10A FZD3 PPP3CB FZD2 FZD7 FZD6 CHUK FZD9 TNFRSF1A TPTEP2-CSNK1E;CSNK1E MAPK8 MAP2K7 AXIN1 AXIN2 NFKB1 WNT16 CALM1 LRP5 LRP6 WNT11 WNT7A FZD5 FZD8 KIF5B MAPT SNCA WNT2B CSF1 INS;INS-IGF2 MME WNT1 WNT2 WNT3A WNT7B WNT5A DKK1 IL6 NOS1 PSMA4 XBP1 EIF2AK3 TUBB3;TUBB6 CYBB ERN1 DDIT3 FADD ATF6 ADAM10 EIF2S1 GRIN2B CASP8 TRAF2 CSNK2A1;CSNK2A3 IL1B RELA MAPK9 APC MAPK10 ATP2A1 PIK3C3 CAPN2 RTN4 PIK3R4 AGER ATP2A2 TUBA1A ULK1 CCL18 SIGNALING%WIKIPATHWAYS_20260810%WP5097%HOMO SAPIENS CCL18 signaling ZEB2 MMP2 AK4-1 CCR8 CDH2 PTK2B GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260810%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis GRIP1 NR4A1 FRMPD3 ARC ADARB1 ZFYVE27 MAP2K2;MAP2K1 GLUL SH3GL2 GRIA1 SLC6A13 GRIA2 SLC6A12 STIM1 GRIN2A SLC1A1 MAPK1 SLC1A2 GAPDH-1 SLC1A6 SLC1A7 DLG4 GRIA3 GRIA4 NETO2 SLC6A6 MAPK3 CREBBP GRIN3B GRIN3A SLC6A8 CPEB3 DLGAP3 GRIK5 GRIK3 GRIK4 GRIK1 PICK1 SLC7A11 GRIK2 GRM3 GRM2 GRM4 GRM7 GABRR3 GRM8 NPTN GABRR2 FFAR1 GABRR1 C1QL3 C1QL2 NRXN3 CACNG8 NWD1 SNX27 CACNG2 UBQLN4 ATAD1 MBD5 GRIN1 SLC12A5 GNAQ SYVN1 LHFPL4 SNX14 PLCB1 P4HB GRIN2C GRIN2D GABRB3 GABRB2 GABRB1 ABAT AP2A1 SLC6A1 AP2A2 GABRG3;GABRG2 PDIA2 GABRE GABRD GABRQ GABRA2 GABRA1 ERBB4 GABRP GABRA6 SLC32A1 MAP1LC3B2;MAP1LC3B-1 GABRA5 GAD1 GRM1 GABRA4 GABRA3 SLC6A11 SUMO1 AP2B1 GABRG1 KIF5C EFNB2 ORAI1 GRM5 HDAC10 HDAC1 CAMK2A GNA11 GRIN2B PRKCA SRC HOMER1 GRM6 NRG1 CABIN1 PPP2CB;PPP2CA CRTC1 SLC1A3 GLS2 SDCBP STAT1 STAT3 CDH2 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260810%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex GABPA DNMT3B MCL1 GZMH;GZMB-1 PTEN DNMT3A BCL2 ATM BCL2L1 ETV6 DNMT1 CREBBP FOXO3 SMAD4 GABPB1 TERF2 FLT3 ZFX SMARCA4 EP300 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260810%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis TAP1 IFI35 IFIT1 PSMB8 PIAS1 PTPN2 IFNAR1 IFIT3 MX1-1 IFNG OAS1 IFITM3;IFITM2;IFITM1 IRF9 IRF1 STAT2 SOCS1 JAK1 IFNAR2 STAT1 JAK2 IFNGR1 IFNGR2 TYK2 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260810%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation CRYL1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260810%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy PIK3R4 ATG3 ULK2 BECN1 ATG12-1 ATG10 MAP1LC3A ATG13 ZFYVE1 ATG16L2 ATG4A ATG5 WIPI1 MTOR ATG7 ATG16L1 PIK3C3 ULK1 RB1CC1 FELBAMATE METABOLISM%WIKIPATHWAYS_20260810%WP2816%HOMO SAPIENS Felbamate metabolism CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 EGF EGFR SIGNALING%WIKIPATHWAYS_20260810%WP437%HOMO SAPIENS EGF EGFR signaling CAV2 TNK2 PLD1 BCAR1 PIK3R2 PIK3R1 MTOR MAP2K2;MAP2K1 SH3GL2 ARF6 EIF4EBP1 KRAS MAPK1 AKT1 RAF1 GAB1 NEDD4 SHC1-1 PCNA E2F1 ABL1 NCOA3 RICTOR GAB2 FOXO1-1 CREB1 ROCK1 PTPN5 STMN1 CFL1 ELK1 PTK2 RAP1A PLCE1 PLCG1 NDUFA13 SPRY2 NCK2 PEBP1 NCK1 USP6NL ERRFI1 SP1 INPPL1 CBLC RALB EPS8 GRB10 PLD2 AP2A1 MAP3K4 PIAS3 USP8 RALGDS DNM1 HGS STAMBP AP2S1 STAM2 NOS3 STXBP1 AP2M1 ATXN2 EGFR IQSEC1 STAM PTPRR SH3KBP1 EPS15L1 ERBB2 EPN1 PLSCR1 ASAP1 CAV1 CBL REPS2 CSK GJA1 EPS15 LIMK2 PTPN12 AP2B1 ABI1 FOSB CDC42 PAK1 SH3GL3 VAV1 VAV2 RASA1 PRKCB VAV3 STAT5A STAT5B BRAF GRB2 SYNJ1 JAK2 RPS6KA5 RPS6KA2 HRAS CAMK2A RPS6KA1 PRKCD RPS6KB1 MAP3K2 MAP3K3 FOS SOS1 RAC1 SOS2 PRKCA SRC MAPK4 RALBP1-1 MEF2D RALA-1 ARHGEF1 INPP5D PTK2B PRKCI JUN MAPK9 PTPN11 MAPK14 DOK2 CRK JUND PRKCZ IQGAP1 PTEN PIK3C2B ITCH MEF2A MAP4K1 PDPK1 MEF2C MAPK8 MAPK7 MAP2K5 CBLB MAP3K1 EGF ATF1 RIN1 ELK4 PTK6 FOXO4 JAK1 STAT1 STAT3 CRKL RPS6KA3 PXDN RAB5A SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260810%WP2267%HOMO SAPIENS Synaptic vesicle pathway CPLX3 SLC17A6 SLC17A7 STX3 SLC17A8 STX2 SYT1 SNAP25 DNM3 CLTCL1 CLTC CLTA DNM2 SLC25A4 VAMP2 DNM1L SLC38A1 AP2A1 AP2A2 DNM1 AP2S1 STXBP1 AP2M1 SLC32A1 AP2B1 RAB3A PARK7 RIMS1 SLC18A1 SLC1A3 SLC18A2 SLC18A3 UNC13B NSF UNC13C UNC13A STX1A SYP SLC6A4 SYN3 SYN2 SYN1 NAPA SLC22A3 CACNA1B CACNA1A ATP1A2 CLN8 CPLX2 CPLX1 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260810%WP3407%HOMO SAPIENS FTO obesity variant mechanism ARID5B TBX1 PPARGC1A FTO IRX5 IRX3 PRDM16 UCP1 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260810%WP4925%HOMO SAPIENS Unfolded protein response EIF2AK3 ATF4 MBTPS2 ERN1 DDIT3 RTCB ATF6 IL1B TXNIP BID NFE2L2 EIF2S1 BCL2 TP53 PPP1R15A BBC3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MBTPS1 BCL2L11 CASP2 XBP1 HSPA5 PMAIP1 GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260810%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells PRKCB DCT PMEL ASIP TYRP1 ARRB1 ARRB2 GNA15 GPR143 MLANA TYR MC1R PRKACA-1 POMC PRKACB-1 ADCY4 ADCY2 SERPINF1 CREB1 VEGFA MITF GNAS-1 PLCB3 PLCB4 ADCY9 GNAQ PLCB1 PLCB2 ITPR1 ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260810%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway HIF1A PDGFD PTPN11 COL1A1 JUND ACE2 TGFBR1-1 SP1 MAPK1 IL11RA RAF1 RACK1 IL6ST MAS1 MAP2K6 IL11 SMAD4 TGFB1 TGFBR2 CCN2 SMAD2;SMAD3 F12 AGT COL1A2 AGTR1 NOX4 RRAS ACTA2 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260810%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias ITGB6 SMAD1 SMAD9 SMAD5 SMAD6 ZEB2 ZFYVE9 ADAMTSL2 TGIF1-1 HRAS MAPK3 LIF TGFBR3 CREBBP ENG SMAD4 LTBP3 LTBP1 ADAMTS10 TNF FOXH1 ZNF423 FKBP1A TGFBR2 SKI BAMBI FOS TFE3 SERPINE1 MAPK9 JUN SPP1 TGFBR1-1 WNT1 FST LEFTY2;LEFTY1 SMAD7 RUNX3 NOG TGFB1 INHBA EGF IFNG NFKB1 BMP4 LEF1 SMAD2;SMAD3 FBN1 JAK1 THBS1 STAT1 CTNNB1 STAT3 RUNX2 SKIL EP300 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260810%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses CEBPB ALDH1L1 CREB1 MTHFR ADH5 CBS;CBSL ALDH1A1 MTR-1 CYP2E1 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260810%WP5548%HOMO SAPIENS Blood based neuroinflammation markers TNF CCL5 CRP GRN TREM2 IL6 ADM CX3CL1 CCL23;CCL15 CCL11 OLR1 IL1B CHI3L1 TSPO NEFL CCL13;CCL2 TAC1 GFAP BDNF TREM1 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260810%WP699%HOMO SAPIENS Aflatoxin B1 metabolism AKR7A3 GSTM1;GSTM2-1 CYP2A13;CYP2A6;CYP2A7-1 EPHX1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AKR7A2 CYP1A2 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260810%WP5145%HOMO SAPIENS COVID 19 structural coverage map GDAP2 APOA1 UBA52 ACE2 UBB;UBC TAB1 PARP9 NLRP12 ISG15 NRP1 IGHMBP2 MACROH2A2 MACROH2A1 MRM2 MACROD1 MACROD2 CMTR1 PAIP1 UPF2 TOMM70 UPF1 AQR PARP14 SLC6A19 MPP5 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP69%HOMO SAPIENS T cell receptor signaling VAV3 ATF2 PIK3R2 PIK3R1 NFATC1 MAP2K2;MAP2K1 NFKBIA GRB2 MAPK1 AKT1 RAF1 HRAS MAPK3 SHC1-1 PRKCD GAB2 CREB1 FOS SOS1 CD3G CD3E CD3D TRAF6 GRAP2 ZAP70 LCK LCP2 CARD11 BCL10 ITPR1 PTK2B MALT1 FYN RELA MAPK9 JUN PLCG1 ICOS PSTPIP1 PTPN11 DBNL MAPK14 CD4 SKAP1 PRKCQ FYB1 CD28 CRK CD247 LAT NCK1 WAS IKBKB IKBKG MAP3K7 MAP4K1 RIPK2 CHUK PDPK1 CD8A MAPK8 ITK CBLB CBL NFATC2 NFKB1 MAP3K14 SH2B3 MAP3K8 CDC42 PAK1 CRKL VAV1 REL ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260810%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ITGB6 ITGB8 CACNA1S ITGB7 ITGA4 ITGA2 RYR2 ITGA7 ITGB1 ITGA6 ITGA5 ITGA9 CTNNA1 ACTG1 ITGB3 ITGB4 ITGAV LAMA2 ACTN3 ACTN2 CACNG8 DES EMD CACNG2 DMD CTNNA2 TCF7L1 SGCD SGCA SGCB TCF7 DAG1 SGCG CACNA2D1 CACNA2D3 CACNA2D2 CACNA2D4 CACNB1 CACNB2 DSP CACNB3 ITGA3 CACNB4 PKP2 DSG2 ACTN4 ITGA8 DSC2 CACNG6 CACNG7 CTNNA3 CACNG1 CACNG3 CACNG4 CACNG5 SLC8A1 GJA1 ACTN1 LMNA ITGA2B LEF1 ITGB5 ATP2A2 ITGA1 TCF7L2 ACTB-1 CTNNB1 CACNA1D ITGA10 CDH2 CACNA1C ITGA11 CACNA1F JUP HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260810%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming NOL9 HDAC2 FTO IFITM3;IFITM2;IFITM1 HDAC1 DNMT3A EZH2 PIP4K2A ANKRD13C DNMT1 CREBBP IRS1 GGT6 YTHDF3 CADM1 TET2 EP300 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260810%WP229%HOMO SAPIENS Irinotecan pathway BCHE SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 UGT1A1;UGT1A6 ABCG2 ABCC1 CES2 CES1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP2D6;LOC107987479;LOC107987478-1 RETT SYNDROME%WIKIPATHWAYS_20260810%WP4312%HOMO SAPIENS Rett syndrome TCF4 HDAC5 SYNGAP1 CRK HDAC1 HDAC8 BRAF SMC1A GRIN2A STXBP1 GABRD SHANK3 MEF2C GRIN2B NCOR1 GABBR2 MECP2 EIF2B2 HTT GNAO1 GABRA3 KDM5B TRRAP SCN8A FOXG1 SATB2 SYNE2 GPS2 CHD4 RHOBTB2 CECR2 TAF1B HIVEP2 SCN1A SRRM3 CDKL5 KCNJ10 ACTL6B SMARCA1 SMARCA2 NCOR2 XAB2 TBL1XR1 IMPDH2 HAP1 SCN2A SMARCA4 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260810%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development SOST NOTCH2 DKK1 NOTCH1 ALPL SP7 NOTCH3 KLF4 NOTCH4 CTNNB1 BMP7 HNF1A RUNX2 DMP1 DSPP INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260810%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy LRSAM1 HSPB8 NDRG1 LITAF FGD4 RAB25 SH3TC2 KIF1B RABAC1 EGR2 RAB4A RAB4B GDAP1 RAB11A FIG4 RAB7A HSPB1 RAB11B PMP22 SBF2 MTMR2 DNM2 MPZ RAB3A NEFL MFN2 RAB3B OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260810%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS CNTF OLIG1 OLIG2 PDGFB FGF2 CNP GLI2 SHH SOX8 SOX6 NKX2-6 MOG OMG MYT1 MAG LIF TNF IGF1 BMP4 SOX9 ASCL1 SOX5 IL1B SOX10 BMP2 MBP PLP1 CXCL2;CXCL3;CXCL1-1 NKX2-2 INSULIN SIGNALING%WIKIPATHWAYS_20260810%WP481%HOMO SAPIENS Insulin signaling MAP2K3 SOCS3 PRKAA1 PIK3CD PIK3R3 GYS2 TSC2 TSC1 RAB4A PIK3R2 PIK3CB PIK3R1 SNAP25 PFKL MTOR MAP2K2;MAP2K1 PIK3CA ARF6 EIF4EBP1 MAPK1 AKT1 RAF1 GAB1 EIF4E RPS6KA6 MAP3K11 ENPP1 MAP2K6 IRS4 MAP3K6 MAP3K5 GYG1 MAPK3 SHC1-1 IRS1 INPP4A STXBP3 STXBP4 RRAD STXBP2 PPP1R3A FOXO1-1 KIF3A EHD1 ARHGAP33 EHD2 MAP3K13 ARF1 IRS2 SNAP23 PTPRF VAMP2 FLOT1 AKT2 FLOT2 CAP1 MAP4K2 PRKAA2 KIF5B MINK1 TBC1D4 ELK1 MAP3K9 RHOJ RHOQ CYTH3 STX4 SGK3;C8orf44-SGK3 MAP4K5 MAP4K3 SH2B2 MAP4K4 REG1B;REG1A SORBS1 MYO1C FOXO3 PFKM INPPL1 CBLC GRB10 MAP3K4 STXBP1 LIPE PTPN1 CBL MAP3K8 INSR XBP1 PRKCB SLC2A4 TRIB3 GRB2 SGK1-1 RPS6KA4 RHEB RPS6KA5 RPS6KA2 HRAS RPS6KA1 PIK3CG PRKCD RPS6KB1 MAP3K2 RPS6KB2 MAP3K3 FOS SOS1 RAC1 SOS2 PRKCA MAPK6 MAPK4 PRKCI MAP3K10 PRKCH JUN MAP3K12 MAPK9 GSK3A PTPN11 MAPK14 PRKCQ CRK GRB14-1 MAPK12 MAPK13 GSK3B MAPK10 PRKCZ MAPK11 IKBKB PTEN PIK3C2G PIK3C2A MAP3K7 MAP4K1 MAP2K4 PDPK1 PIK3C3 MAPK8 MAPK7 MAP2K7 MAP2K5 CBLB PIK3R4 MAP3K1 MAP3K14 EGR1 SRF SHC2 SHC3 SOCS1 SLC2A1 GYS1 RAPGEF1 IGF1R RPS6KA3 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260810%WP4262%HOMO SAPIENS Breast cancer pathway FZD5 RB1 MRE11 HEY2 FZD8 PIK3CD PIK3R3 BRCA1 E2F3 PIK3R2 PIK3R1 MTOR FGFR1 MAP2K2;MAP2K1 PIK3CA DLL1 NBN DLL3 DLL4 KRAS MAPK1 AKT1 RAF1 FGF3 MAPK3 SHC1-1 FGF6 SKP1 E2F1 FGF9 NCOA3 GADD45B FGF23 GADD45A GADD45G RAD50 CDK6 AKT2 RAD51 AKT3 FGF20 CDK4 FGF22 FGF17 HES1 HES5 FGF16 ATM ATR FGF18 FRAT2 CSNK2A2 JAG2 CETN3 HEY1 NCOA1 TCF7L1 HEYL FGF7 SFRP4 CSNK2B NOTCH2 WNT2B NOTCH1 FGF1 BRCA2 FGF4 POLK SP1 ESR1 FGF8 APC2 E2F2 BAK1 TNFSF11 WNT1 WNT2 EGFR WNT3A CCND1 WNT7B ERBB2 WNT5A CSNK1A1 ESR2 KIT FGF10 PGR CTNNB1 ARAF MYC FLT4 BRAF NFKB2 GRB2 CDKN1A FGF5 HRAS RPS6KB1 DDB2 RPS6KB2 CSNK2A1;CSNK2A3 FOS SOS1 SOS2 NRAS TP53 BAX FZD10 JUN WNT5B APC TCF7 GSK3B FGF2 WNT6 DVL1 DVL2 DVL3 PTEN WNT3 WNT4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD7 FZD6 FGF21 FZD9 PARP1 AXIN1 EGF AXIN2 IGF1 WNT16 LEF1 LRP5 SHC4 LRP6 SHC2 SHC3 WNT11 TCF7L2 WNT7A NOTCH3 NOTCH4 IGF1R FGF19 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260810%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling TGFB1 LOXL4 MAPK14 LOXL1 TGFBR2 LOX TGFBR1-1 SMAD2;SMAD3 LOXL2 GREM1 BMPR2 BMPR1A SMAD4 MAPK8 BMP1 MAPK9 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260810%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer CCL5 IL25 LGALS3 CCL20 REG4 CCL28 TGFB2 LGALS9C;LGALS9;LGALS9B IL17F IL17D IL17C IL17B IL5 VEGFB CXCL12 VEGFC VEGFD TGFB3 CXCL8 IL13 TNF MMP9 TGFB1 LGALS1 VEGFA IFNG IL6 IL10 IL1B CCL13;CCL2 IL12B CSF2 IL12A IL23A IL17A CXCL2;CXCL3;CXCL1-1 IL2 IL4 CXCL5;CXCL6 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260810%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways HMGCS1-1 SREBF1 LSS SREBF2 IDI1 SOAT1 SOAT2 HSD17B7 FASN ACSL4 MVK FDFT1 MSMO1 CYP46A1 FDPS ACAT2 TM7SF2 EBP MVD FADS2 NSDHL PMVK ACSL1 NR1H2 SC5D CYP51A1 ACOT2;ACOT1 FADS1 MYLIP CYP27A1 SQLE GGPS1 ELOVL3 SCD NR1H3 DHCR24 ACSL3 ELOVL4 DHCR7 CH25H ELOVL2 ABCG1 LBR HMGCR ELOVL5 ABCA1 HMGCS2 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260810%WP585%HOMO SAPIENS Interferon type I signaling MAP2K3 IFNAR1 SOCS3 PIK3CD STAT5A PIK3R2 PIK3R1 MTOR EIF4EBP1 EIF4A1 RPTOR RACK1 EIF4E RPS6KA4 MAP2K6 RPS6KA5 IRS1 MAPKAP1 EIF4B RPS6 TYK2 GAB2 MLST8 RPS6KB1 PDCD4 PIAS1 CREB1 IRS2 RAC1 STAT4 STAT2 RAP1A ZAP70 LCK FYN PTPN11 MAPK14 PTPRC CRK IRF9 PTPN6 PRMT1 PIAS3 CBL MAP3K1 SOCS1 JAK1 IFNAR2 STAT1 RAPGEF1 STAT3 CRKL VAV1 REL NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260810%WP4331%HOMO SAPIENS Neovascularization processes HIF1A EPHB2 NOTCH1 SMAD1 SMAD9 TGFB2 PDGFB TGFBR1-1 SMAD5 ANGPT1 NFKB2 ACVRL1 EPHB4 DLL4 CXCL12 MAPK1 AKT1 TGFB3 MAPK3 MAPK8 MMP9 TGFB1 KDR JAG1 NFKB1 SMAD2;SMAD3 KITLG KIT CXCR4 NOTCH3 NOTCH4 RELB REL RELA FLT4 MAPK9 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260810%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth HMBOX1 HIPK1 HIPK2 CDKN1B FANCONI ANEMIA%WIKIPATHWAYS_20260810%WP5465%HOMO SAPIENS Fanconi anemia MRE11 BRCA1 BRCA2 PTEN NBN DCLRE1B CTDP1 CEBPD FANCD2 FAN1 CENPS-CORT;CORT;CENPS UHRF2 UHRF1 EGFR FAAP24 BRIP1 LOC105377022;FANCB SLX4 USP1 MEN1 FAAP100 FANCI FANCM CENPX FANCL XRCC2 REV1 FANCA FANCC RAD50 FANCE RFWD3-2 RAD51 PALB2 FANCG FANCF MAD2L2 RAD51C ERCC4 UBE2T ATM ERCC1 ATR MCM2 HSP90B1 SMARCA4 PPAR SIGNALING%WIKIPATHWAYS_20260810%WP3942%HOMO SAPIENS PPAR signaling FABP4 APOA2 SLC27A5 LPL SLC27A4 APOA1 ILK UCP1 GK APOA5 UBB;UBC PLTP CYP7A1 PDPK1 CD36 APOC3 PPARA PPARD FADS2 ACSL1 ACOX1 PLIN1 PCK1 CYP27A1 RXRB SCD RXRA NR1H3 PPARG OLR1 SLC27A1 EHHADH-1 ADIPOQ SCP2 CPT2 MMP1 RXRG PCK2 SORBS1 ANGPTL4 ACAA1-1 ME1 CPT1C CYP8B1 LOC100509620;LOC112267859;AQP7 FABP1 HMGCS2 FABP3 PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260810%WP4022%HOMO SAPIENS Pyrimidine metabolism DPYS TYMP TK2 ENPP3 POLR2C POLE UPP1 ENTPD1 POLD2 TK1 ENTPD3 CAD NME2 RRM1 NME3 CTPS2 CTPS1 UPB1 DCK NME1 TYMS DCTD UCK1 NME6 NME7 DPYD POLR1A UMPS POLR1B POLR1C RRM2-1 RRM2B CMPK1 POLR1D CMPK2 ENPP1 POLR1F UPRT POLR1H DCTPP1 PRIM2 DTYMK NME4-1 PRIM1 NT5C POLD3 POLD4 POLR2A POLR2B POLR2D POLR2E POLR1E NT5M POLR2G POLR2H POLR2I POLR2L DUT PNPT1 POLR3GL DHODH UCKL1 POLE4 POLA1 POLA2 POLR2J;POLR2J2;POLR2J3 POLR3A POLR3B POLR3C POLE2 POLR3D POLE3 POLR3F POLR3G POLR3H POLR3K POLD1 POLR3E CDA DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260810%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development CDKN1B TSC2 TSC1 NFATC1 MTOR DLL1 RPTOR DEPTOR MLST8 FOXO1-1 RBBP4 HIP1 CASP3 CREB1 CDK6 SIRT1 CDK4 HES1 HES5 TP53 LIN9 LATS2 REST MAPT H3-3A LIN54 GMNN AKT1S1 GLI1 DCAF7 DNER LIN52 RBL2 APH1A RBL1 NOTCH1 NCSTN TFDP1 SPRY2 GSK3B TFDP2 AMPH FGF2 RAD54L2 CASP9 E2F4-1 LIN37 E2F5 EIF2B5 TFAP4 NEUROG2 APP PSENEN BACE1 DNM1 CCND1 SMARCB1 CSNK1A1 DYRK1A PSEN1 CRY2 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260810%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells MMP9 EGF SPP1 IGF1 KDR BIRC5 ETS2 IL6 PTEN CD63 HSPB1 CD81 SORBS2 PDLIM5 GATA4 STAT3 TLR4 EGFR SOD1 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260810%WP5390%HOMO SAPIENS Pancreatic cancer subtypes REG4 CTSV;CTSL PLA2G10;LOC100652777 CDH17 SPRR3 ST6GALNAC1 SERPINB3;SERPINB4-1 ANXA8;ANXA8L1 GPR87 LYZ-1 KRT20 CST6 AREG LGALS4 TFF3-1 TSPAN8 VSIG2 SPRR1A;SPRR1B AGR2 AGR3 FAM3D TNS4 KRT6B;KRT6C;KRT6A CTSE FAM83A SPINK4 FGFBP1 S100A2 KRT7 ANXA10 SCEL LEMD1 DHRS9 KRT17 MYO1A SLC2A1 PRR15L KRT15 LY6D TFF1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 VGLL1 CLRN3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260810%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR2F TBP TAF12 TAF13 POLR2C GTF2H1 GTF2H3 ILK GTF2F2 GTF2H4 ERCC3 TAF7 TAF6 TAF5 MNAT1 ERCC2 POLR1A POLR1B POLR1D POLR2A POLR2B POLR2E POLR1E POLR2G CDK7 POLR2H POLR2I POLR3E POLR2J;POLR2J2;POLR2J3 POLR3B GTF2H2C;GTF2H2C_2;GTF2H2 POLR3D GTF2A2 CCNH GTF2B TAF9 POLR3H GTF2E1 POLR3K GTF2E2 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260810%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling PDHA1 RXRA CYP24A1 HLA-DRA PFKFB4 TSC2 HK3 GSK3B TSC1 IL10 PRKAA2 MTOR CD86 PIK3CA CD80 AKT1 IL12A VDR LDHA MYC RELA EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260810%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects CXCL12 PRL MYB ERBB4 RGS16 KLF2 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260810%WP3995%HOMO SAPIENS Prion disease pathway SPI1 TBP POU2F2 FGFR1 CHD2 PDIA3 BCL2 PRNP CTCF BCL11A MAPK1 EBF1 PAX5 BATF IRF4 RFX5 MAPK3 NCAM1 MEF2C RXRA CASP3 CREB1 NFKB1 ELK1 PTK2 SMC3 RAD21 STAT3 HSP90B1 FYN EP300 HSPA5 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260810%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 ADCY10 ADCY9 ADRA2C ADRA2B ADRA2A ADRB1 ADRB2 ADRA1D TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260810%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis FOXO1-1 TNF RXRA CREB1 PPARGC1A IRS2 SLC2A4 IL6 PPARG LPIN1 CEBPA CEBPB ADIPOQ CEBPD LEP INSR NR3C1 NRIP1 PCK2 IRS1 MAPK8 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260810%WP528%HOMO SAPIENS Acetylcholine synthesis PCYT1A PDHA1 CHKA CHAT ACHE PEMT DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260810%WP5053%HOMO SAPIENS Development of ureteric derived collecting system GLI1 GRIP1 SMAD1 HOXD11 RET HOXA11 TGFB2 EYA1 RARB GLI2 SIX1 SHH ETV4 GDNF ITGA8 PAX2 BMPR1A GLI3 SALL1 CCND1 BMPER FST SIX2 GPC3 GDF11 CRIM1 TGFB1 ANOS1-1 CELSR1 ETV5 CTDNEP1 MYCN VANGL2 BMP4 FRAS1 RARA SPRY1 DCN FREM1 FREM2 WNT11 BMP5 BMP2 BMPR2 GFRA1 BMP7 RARG SMO NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260810%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members EIF2AK3 ERN1 GSK3B IKBKB NFKB2 IKBKG NFKBIA MAVS CHUK CUL1 BTRC CREBBP SKP1 PARP1 DDX58 TFPI2 CLDN6 MAP3K14 ZC3HAV1 TIPARP PARP16 PARP12 PARP10 TBK1 RBX1 RELB PARP14 EP300 IL17 SIGNALING%WIKIPATHWAYS_20260810%WP2112%HOMO SAPIENS IL17 signaling IL25 GSK3B IL17F IL17D IL17C IKBKB IL17B SP1 PIK3CA IKBKG MAP3K7 CEBPB MAPK1 AKT1 CEBPD JAK2 MAPK3 NFKB1 MAP3K14 TRAF3 TRAF6 TRAF3IP2 IL17RE NFKBIB IL17RD JAK1 IL17RB IL17RC IL17A IL17RA STAT3 RELA PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260810%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer PDK1 CDKN1B PIK3R3 TSC2 GSK3B PIK3R2 PIK3CB PIK3R1 MTOR PTEN PIK3CA EIF4EBP1 GRB10 KRAS AKT1 RPTOR NOS3 RHEB HRAS MAPKAP1 PIK3CG RICTOR RB1CC1 MLST8 FOXO1-1 ATG13 NRAS BAD FOXO4 TFEB FOXO3 ULK1 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260810%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PTPN11 CD28 PIK3CD PIK3R3 PIK3R2 PIK3CB PIK3R1 PTPN6 CD86 PIK3CA CD80 CTLA4 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PPP2CB;PPP2CA TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260810%WP691%HOMO SAPIENS Tamoxifen metabolism CYP2A13;CYP2A6;CYP2A7-1 CYP2D6;LOC107987479;LOC107987478-1 FMO3 CYP2C9;CYP2C19 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1B1 CYP2E1 SULT2A1-4 CYP1A2 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260810%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle ANKRD1 VEGFA HBEGF IFNG JUND ADAM10 ATF3 IL1A IL1R1 EIF4EBP1 CCN1 ZEB1 EIF4E MYOG IL18 WDR1 MSTN IFRD1 DUSP14 NR4A3 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260810%WP4963%HOMO SAPIENS p53 transcriptional gene network SESN2 PRKAA1 PIDD1 TSC2 SESN1 MTOR CDKN1A CDC25C CDC25A FASLG RRM2B RPTOR CCNE1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A LIF APAF1 DEPTOR PCNA PMAIP1 TNF MLST8 SFN ICAM1 DDB2 SLC7A11 GADD45A PML CX3CL1 ADORA2B PRKAA2 ISG15 CDK2 SERPINE1 FAS CCL13;CCL2 BAX IRF5 AURKA BTG2 SAT1 E2F7 ACAD11 CCNG1 POLH AKT1S1 ERCC5;BIVM-ERCC5 SERPINB5 MSH2 ULK2 TRAF4 SCO2 ADGRB1 NOTCH1 ULBP1-2 XPC IRF9 DRAM1 ZMAT3 PERP POLK TP53INP1 PTEN RPRM ULBP3;ULBP1;RAET1G;ULBP2;RAET1L TIGAR SIVA1 FUCA1 MLH1 TP53I3 MGMT NANOG;NANOGP8 ALDH4A1 PRKAG1 PRKAG2 PRKAG3 FANCC GPX1 XRCC5 PRKAB2 PRKAB1 GLS2 SLC2A1 THBS1 NCF2 BBC3 DDIT4 CPT1C ULK1 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260810%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders CYP11B1;CYP11B2 CYP27B1 SPP1 FGF23 CYP24A1 NFKB1 ALPL SLC34A1 FGFR2 NFKB2 ORAI1 CDKN1A KL GALNT3 PHEX FAM20C ENPP1 ROS1 CCND1 FGFR3 PTH DMP1 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260810%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway RHOA TGFB3 ARHGAP29 ARHGEF2 TP63 IRF6 TFAP2A MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260810%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHC SDHD SDHAF2 SDHA SDHAF3 SDHB SDHAF1 SDHAF4 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260810%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification MGP CALU JAG1 VEGFA NOTCH1 ALPL GJA5 DLL1 PLAT DLL3 ITGA1 DLL4 SOX6 LPAR1 JAG2 FGFR3 SAT1 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260810%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system MDH1 GRIA1 GRIA2 HSPB1 MAPK1 AKT1 DLG4 MAP3K5 VIM MAPK3 MAPRE1-1 SGK3;C8orf44-SGK3 MAP1B MAPT CSNK2A2 SNCA HIF1A CSNK2B APOE SP1 TUBA1C SHH HSP90AA1 TARDBP NR3C1 EGFR MYH9 SMAD7 CDC20 KAT5 HTT MIF FOXP3 MAP1LC3A ERG NDUFV1 CFTR DYNC1I2 KALRN PRDX2 ATXN3 PARK7 RHOT1 GRK2 PRDX1 UBD HSPA8 TUBA4A G3BP1 EP400 CCDC141 PROM1 HSPA4 FUS BBIP1 CNOT6 CTNNB1 DLG2 OPTN-1 VCP-1 RAD23B CTTN PRKN ITIH4 DNAJA1-1 NEDD9 HSF1 EP300 MIIP SOD1 ELP1 ARID3A CYBB SQSTM1 TUBB3;TUBB6 SNCAIP GARS1 ATP13A2 TUBA3E;TUBA3C-1 STUB1 TUBB4A;TUBB;TUBB8B;TUBB8 HDAC9 BCL2 HDAC6 ELP3 SGK1-1 MYD88 BIRC5 RAC1 ISG15 SIRT2 BAX AURKA PTK2B DCTN1 ACTR1A PRKCE GSK3A PPP1CA APC POU5F1;POU5F1B GSK3B PXN PRKCZ VHL MAPK8 HDAC11 XRCC6 SMAD2;SMAD3 TPPP BDNF COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260810%WP545%HOMO SAPIENS Complement activation CFD C3-1 C1QB C5 C1S C1R CFB C8B CFP C8A C2 C6 C8G C7 C9 MASP2 MASP1 CD55 C1QC LOC110384692;C4A;C4B_2;C4B AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260810%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS MAPK14 CASP9 PPP3CA MAP2K2;MAP2K1 GRIA1 CASP1 BCL2 PPP3CB SLC1A2 TOMM40 DERL1 NEFM NEFH MAP2K6 MAP3K5 PRPH TNFRSF1A CCS APAF1 ALS2 CAT DAXX TNF CST3 CASP3 SMIM40 RAC1 GPX1 BID NEFL BAD PPP3CC TP53 NOS1 BAX BCL2L1 SOD1 RAB5A CYTOSINE METHYLATION%WIKIPATHWAYS_20260810%WP3585%HOMO SAPIENS Cytosine methylation TDG IDH1 TET1 DNMT1 MBD3 IDH2 MECP2 TET2 RETINOL METABOLISM%WIKIPATHWAYS_20260810%WP5188%HOMO SAPIENS Retinol metabolism SDR16C5 CYP2W1 CYP2A13;CYP2A6;CYP2A7-1 RDH12 AWAT2 ADH1C;ADH1B;ADH1A PNPLA4 AOX1 LRAT RDH13 BCO1 DHRS9 CYP1A1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RPE65 DHRS4 PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260810%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function DRD1 PDE8A GRIA1 GRIN2A GUCY1B1 DRD2 PRKACA-1 CAMK2A GRIN2B ADCY4 ADCY3 ADCY2 ADCY1 CREB1 ADCY8 ADCY7 ADORA2A ADCY6 PDE3B PDE4B CHRNA7;CHRFAM7A PDE4A ADCY5 PDE8B GUCY1A2 GUCY1A1 PDE4C PDE12 PDE5A PDE9A PDE1C PDE1B PDE1A GRIN1 PDE11A ADCY10 ADCY9 PDE6D PDE6C PDE6B PDE6A PDE4D-1 PDE6H PDE2A PDE10A PPP1R1B PDE3A PDE7B GRIN2C PDE7A GRIN2D PRKG1 NOS1 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260810%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer ALK GAREM2 KSR1 FOS SOS1 SOS2 BRAF MAP2K2;MAP2K1 ELK1 KRAS RAF1 SHC1-1 MAPK3 MYC JUN INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260810%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway MAPK14 ATF2 IL1RAP MAP2K3 SAFB IRAK1 IRAK2 MAPK10 MAPK11 IKBKB MAP2K2;MAP2K1 MKNK1 NFKBIA MKNK2 MAP3K7 MAPK1 TOLLIP TAB3 MAP2K4 TAB2 EIF4E CHUK TAB1 MYD88 MAP2K6 RPS6KA5 MAPK3 MAPK8 MAP2K7 MAP3K3 MAP3K1 FOS NFKB1 IRAK4 TANK MAP3K14 TRAF6 ELK1 IL1A IL1R1 IRF7 NFKBIB MAP3K8 MAPKAPK2 MBP MYC RELA MAPK9 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260810%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways SQSTM1 ACACA ENPP3 MDH1 KSR1 TSC2 TSC1 PFKL PKM MTOR CDH13 RAPGEF5 FLT1 ARNT FASN GAPDH-1 AKT1 RPTOR RHEB PDGFRB CREBBP PDGFRA PGK1 DEPTOR ALDOC ENO1 MLST8 PGM1 KDR ALDOA HK3 CAMK1 SETD2 PHGDH PSPH PFKM AKT1S1 HIF1A PSAT1 ACACB KDM5C EFCAB3 PLOD2 ENO2 ENO3 PDGFB PGM2 CEP290 PBRM1 VHL PTEN TPI1 SDS PKLR TOX2 ALDOB GRB10 SDSL PGBD5 LDHD KCNJ2 ZEB1 LDHA;LDHC SSPN PFKP BAP1 EGFR ACLY BHLHE41 LDHB MAP2K5 VEGFA GPI SLC2A1 SHMT2 HK2 SHMT1 STAT3 HK1 LDHA ME1 EP300 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260810%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition RPS6KB1 INSR SLC2A4 AKT2 IRS1 MTOR TBC1D4 RPS6 BLADDER CANCER%WIKIPATHWAYS_20260810%WP2828%HOMO SAPIENS Bladder cancer TYMP RB1 HBEGF PIK3R2 PIK3R1 MAP2K2;MAP2K1 BRAF KRAS CDKN1A MAPK1 RAF1 CDKN2A EGFR RPS6KA5 DAPK2 MDM2-2 HRAS DAPK3 CXCL8 CCND1 UPK3A E2F1 ERBB2 MMP9 EGF VEGFA RASSF1 NRAS CDK4 TP53 DAPK1-1 SRC THBS1 MMP1 MMP2 ARAF CDH1 MYC FGFR3 IL3 SIGNALING%WIKIPATHWAYS_20260810%WP286%HOMO SAPIENS IL3 signaling ENPP3 PIK3CD STAT5A STAT5B IL5RA PIK3R2 PIK3R1 MAP2K2;MAP2K1 BCL2 GRB2 YWHAB MAPK1 AKT1 RAF1 YWHAQ PRKACA-1 JAK2 HRAS MAPK3 SHC1-1 CXCL8 GAB2 SYK FOS SOS1 BAD SRC INPP5D FYN JUN PTPN11 IL3RA PTPN6 CCR3 CSF2RB MAPK8 LYN CD69 TGFB1 CBL IL3 CD86 JAK1 BCL2L1 HCK RAPGEF1 STAT3 CRKL VAV1 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260810%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes MTPN MRPS33 RB1 AKAP8 DNAJB1 CDKN1B POLR2C PPP1R7 POLD2 SH3BP4 E2F3 PDLIM7 MPZL1 SLC12A2 GALNT7 GALNT1 TXNRD1 AP3D1 ARCN1 SMC1A SPCS3 TMEM59 ATP6V0E2;ATP6V0E1 FMNL2 AXL EIF4E NEDD4 LAMTOR5 CUL4B TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A BET1 IRS1 E2F1 CHAF1A ATRX TNFSF9 MYCN LAMC2 CDK6 PAFAH1B2 PKN2 IFRD1 ANXA2 LPL TP53INP1 AP2A1 PPIF LAMC1 COL4A2 RAD23B HDAC4 EHMT2 TYMS PANX1 RHEB FADS2 FADS1 GNAI2 PTPA PLXND1 PRKCI PDE3A VCAM1 MAPK14 FGF2 PPP3CA PPP3R1 MAPK7 SERPINE2 BACH1 RRP8 MYLIP RAVER2 CDK5RAP1 ANKFY1 VPS39 PPP2R5C CDK5RAP3 TMEM41B-1 HOXA5 MBNL1 SCAMP1 GTPBP3 WDR82 FAR1 OTULINL ABCF2-H2BE1;ABCF2 HACD3 RAB5C IQGAP3 RDH10 GRPEL2 CEP72 VTI1B GSTM4 CLDN1 PHC2 PPP5C SFXN1 STRN FERMT2 HOXD8 ASH2L CSRP1 NELFCD SLC7A6 PTRH1 VAMP3 TAF9B SRSF10 TRMT1 TTC9C SMAD1 HIPK3 PISD WDR11 SNX15 NUCB1 LY6K GPAM TUSC2 LTN1 MSI2 LCLAT1 IPO4 SHOC2 ABHD10 CDIPT ABHD11 KPNA3 STX7 RAB30 DMTF1 SYPL1 CORO1C SLC9A3R2 THEM4 RAB6A SAC3D1 HMOX1 CD164 BCL6 NCOA3 CNOT9 SLC25A1 ADPGK CALCOCO2 PTBP1 ACP2 SNAP29 PTBP2 AURKB NT5C3A LUZP1 CLOCK SYNE2 NUFIP2 SYNE1 UNC93B1 RAB23 TMEM43 IGF2BP1 LRRC8A ZNF622 SLC25A24 NPR3-1 SLC12A4 MYO10 SLC25A32 MTRR CHORDC1 SEC62 CARHSP1 METTL7A-1 SUCLG2 MAGT1 FXR2 KCNN4 ATP6V0A1 SNX6 HARS1 RAB27B SLC25A22 BRI3BP C1QBP MPDU1 NCEH1 CDKN1C DNMT3B RCOR1 GFM1 PTPRJ MEOX2 NOTCH1 COIL MCL1 TMED3 DHX15 GNL3L-1 CTSC MRPS24 RHOG AP3B1 GAK CDCP1 NT5E FRG1 ELMOD2 BRPF3-1 SSNA1 AMIGO2 CAPG NAPG PGRMC1 ATAD3A;ATAD3B TERT MTX1 SPRYD4 YIF1B ATAT1 TPPP3 TRIP13 C1orf56 GEMIN2 WNT5A CPOX ARID4B TXN2 ARHGDIA ARID2 ATG9A PURA UBE4A CDKAL1 MYO1E GPD2 WDFY1 MATR3 KIT GEMIN7 PPIB SLC1A4 IGF2R DNMT3A TRPV6 DOCK5 DOCK7 TNFAIP2 MAP3K8 CHD1 MTHFD2 TMEM109 SCYL1 UTP15 HSDL1 MARS2 ARFIP2 RBM19 BCKDHB ARID1A RCN2 RFT1 RBMS1 NXN CAND1 SLC4A7 NAA15 TDG ARL10 PLK1 ABCG2 TMED7 LAMTOR3 CCN1 RHOB GNA13 MAPK12 MYB LMNB2 KCNQ1 UAP1 TCL1A BDNF GNPNAT1 GFPT1 PKM KRAS NOTCH2 CXCL12 BACE1 ATG3 SLC25A13 CTNNB1 ITGA2 TM6SF1 BCL2 CDKN1A MET YWHAQ G6PD TGFBR2 CYP1B1 CSNK1D CACNA2D1 SEC23A EZH2 ZEB1 SEC24A CYP51A1 SDCBP GAS2L1 DDX5 NF2 HSD17B12 PGM1 TPM4 SNAP23 PTPRF TPM2 TPM1 CAP1 EHMT1 ANAPC1 CEBPB CDKN2A EGFR UHRF1 UBE2S CCND1 USP1 MAT2A TPM3 NFIA NARS1 PRIM1 PDCD4 POLE4 POLA2 PLAG1 P4HA2 PSAT1 DCAF7 CPNE8 VEZT ACAA2 SRPRB-1 ARF4-1 PWP1 DHX57 ANPEP ARFIP1 CIAO2A POGLUT3 SLC38A1 RARS1 FBXW11 FNDC3B GOLGA7-1 FNDC3A PDLIM5 DHX40 RAB34 RAI14 SRSF9 TMED10 CBFB ADIPOR2 RTN4 UBE2J1 MRPL20 COMMD9 SLC38A2 ATP6V1C1 ATP6V1F PEDS1-UBE2V1;PEDS1 IDH1 SLC4A10 TBCA MOV10 AGO3;AGO1 NCL-1 HNRNPM CHMP2A ANP32B PICALM NRP1 TRAM1 ATP2A2 ADAR MRC2 GYS1 TUBA1A SPTLC1 SH3BGRL3 TMED2-1 ELOVL5 SIGMAR1 PRPF40A CSDE1 POM121;POM121C PXDN PNP-1 PTMA IL11 SIGNALING%WIKIPATHWAYS_20260810%WP2332%HOMO SAPIENS IL11 signaling PTPN11 FES SOCS3 ITGA2 PIK3R2 PIK3R1 IKBKB MAP2K2;MAP2K1 BCL2 GRB2 MAPK1 PIAS3 AKT1 IL11RA RAF1 CHUK IL6ST PDPK1 JAK2 IL11 HRAS MAPK3 RPS6KA1 YES1 RPS6 TYK2 RPS6KB1 ICAM1 IBSP TGFB1 PIAS1 CREB1 BIRC5 ATF1 JAK1 SRC STAT1 STAT3 RUNX2 PTPA FYN RELA EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260810%WP4217%HOMO SAPIENS Ebola virus infection in host CAV2 SOCS3 PIK3CD PIK3R3 PIK3R2 PIK3CB PIK3R1 RAB7A ITGB1 PIK3CA RFC1 CLTCL1 MAPK1 AKT1 AXL NEDD4 MAPK3 CREBBP CLTC ACTG1 CLTA ITGB3 ITGAV RHOA HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 C1QBP HLA-DRA CTSV;CTSL ITGA3 ACTN4 EIF2AK2 EGFR CAV1 EPS15 HLA-DMA ADAM17 ITGA1 TBK1 ACTB-1 RELB CDC42 PAK1 VAV2 TIAM1 REL EP300 ICAM2 ICAM3 HLA-DOA HLA-DOB ITGA4 KPNA1 ITGA2 VPS18 VPS33A TIMD4 TYRO3 CLEC4G TSG101 NFKB2 SCIN ITGA6 VPS11 EIF2S1 VPS16 ITGA5 BST2 CLEC6A HLA-DPB1-1 ASGR1 NPC1-1 TOP1 HAVCR2 CTSB HLA-DPA1 NPC2 GAS6 MFGE8 DDX58 VPS4A HLA-DQB2;HLA-DQB1 CLEC4M;CD209-2 HLA-DMB GSN DAB2IP MERTK CLTB TPCN2 PRKRA VPS41 RAC1 RAB9A FOLR1 IRF3 MBL2-1 IRF7 RHOC RHOB TLR4 RELA IQGAP1 IKBKE HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E VPS39 NFKB1 RASA2 ACTN1 STAT1 IGF1R FLNA FLNB FLNC CAV3 IL4 TFAP2A RAB5A CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260810%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling CNR1 DAGLA RYR2 TRPC1 CCK GNAI1 RYR3 CD38 GNAQ RYR1 CCKBR PLCB1 ITPR1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260810%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition TCF4 TGFB1 FOXC2 HDAC2 HDAC1 SIRT1 SNAI2 SUZ12 PRRX1 KLF8 ELF3 ELF5 SIX1 GSC2 EZH2 SUV39H1 ZEB1 GRHL2 ZEB2 KDM1A CDH1 SNAI1 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2876%HOMO SAPIENS Pregnane X receptor pathway CYP2A13;CYP2A6;CYP2A7-1 PPARGC1A ABCC3 HSP90AA1 CYP2C9;CYP2C19 NR1I2 NCOA2 NRIP1 ABCB1 NCOA3 FOXO1-1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 RXRA UGT1A1;UGT1A6 PSMC5 ABCC4 CYP2B6 SRPX2 DNAJC7 SRC GSTA3;GSTA5;GSTA1;GSTA2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SULT2A1-4 NCOA1 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260810%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging FOXO1-1 AKT1 IGF1R SIRT1 MTOR PTEN COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260810%WP2636%HOMO SAPIENS Common pathways underlying drug addiction DRD1 PRKCG PRKCB GRM5 DRD4 PPP1CA MAP2K2;MAP2K1 GRIA1 GRIA2 GRIN2A MAPK1 RAF1 DRD2 GRIA3 PRKACA-1 GRIA4 CAMK2A MAPK3 ACTC1;ACTG2 ACTG1 PRKACB-1 ADCY1 GRM1 CREB1 ADCY8 CALM1 GNAI1 PPP1CB PRKCA PPP1CC GNAS-1 RAP1B RAP1A ACTB-1 GRIN1 PPP1R1A CAMK4 ARAF GJB1 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260810%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260810%WP2328%HOMO SAPIENS Allograft rejection HLA-DOA C1QB C5 HLA-DOB C8B C8A PECR C2 C6 IL5 IL2RA C7 C9 CXCL11 CD55 HLA-DPB1-1 FASLG C1QC CXCL9 CD40 HLA-DPA1 VIM CXCL8 IL13 PDGFRA ABCB1 HLA-DQB2;HLA-DQB1 CASP8 TNF HLA-DMB CASP3 C3-1 IL10 IL1B IL1A FAS CTLA4 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 IL21 AGTR1 IL17A IL22 CXCL13 CXCR5 PRF1 CCL21 CSNK2A2 CCL19 HARS1 GABPA CD28 HLA-DRA PRKCZ CASP9 CASP7 CXCL12 GDNF LOC110384692;C4A;C4B_2;C4B LRRK2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TGFB1 FOXP3 VEGFA IFNG HLA-DMA GZMH;GZMB-1 BHMT2 CD86 CD80 IL12B IL12A STAT1 COL5A1 IL2 IL4 CD40LG MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260810%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CTCF MSMP CCR2 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260810%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling ITGB2 LY96 IFNB1-4 IRAK1 IRAK2 CD14 IKBKB PIK3CA IKBKG CXCL10 AKT1 CHUK NOS2 MYD88 CBLB TNF LBP SYK NFKB1 IRAK4 FGB TIRAP IL6 FGA RASSF5 IRF3 FGG TRAF6 PLAT PLG RHOA CCL13;CCL2 IL12B SRC TICAM2 TLR4 CXCL2;CXCL3;CXCL1-1 TLR3 FCER1G TICAM1 ITGAM TYROBP REL RELA DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260810%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades CFD C1QB C1S CFB C1R C2 C6 C8G C7 C9 MASP2 MASP1 CD55 C1QC CLTC F2R C3-1 FGB F10 SERPINF2 SERPINE1 PLAT PLG KNG1 F3 BDKRB1 F5 F7 F8 F12 F9 SERPING1 KLKB1 PLAU PROS1 CLU VWF SERPINA5 C3AR1 APOA2 CR2 F2 CPB2 SERPINC1 CFI C5AR1 TFPI LMAN1 SERPINA1 SERPIND1 PROC CFH-3 F13B PLAUR LOC110384692;C4A;C4B_2;C4B THBD CR1L;CR1 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260810%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members TNK2 TNK1 AXIN1 APC DVL1 PLK1 DVL2 DVL3 PARP10 RBX1 CTNNB1 CUL1 BTRC SKP1 PARP1 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260810%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260810%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma VEGFB HIF1A VEGFC VEGFA HIF1AN HEY1 HES1 METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260810%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS1 PTGS2-2 ALOX15 ALOX12 FADS2 ALOX5 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260810%WP1604%HOMO SAPIENS Codeine and morphine metabolism SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 UGT1A1;UGT1A6 CYP2D6;LOC107987479;LOC107987478-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ABCC3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCB1 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260810%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy TGFB1 PPP3R1 AKT1 RASGRF1 NFKB1 STAT3 AKT2 MYEF2 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260810%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling BIRC3 MAPK14 TRAF5 TRAF1 GSK3B RIPK1 HDAC1 FADD IKBKB CASP7 TNFRSF12A NFKB2 NFKBIA MAP3K7 MAPK1 AKT1 RAF1 CHUK MAPK3 MAPK8 CASP8 TNF TRAF2 CASP3 TRIM63 NFKB1 RAC1 AKT2 MAP3K14 TRAF3 NFKBIB RELB CTNNB1 RELA BIRC2 MAPK9 JUN ATM SIGNALING%WIKIPATHWAYS_20260810%WP2516%HOMO SAPIENS ATM signaling ATF2 MRE11 BRCA1 PIDD1 TP73 RIPK1 CHEK2 CHEK1 TLK1 MDC1 IKBKG NBN TP53BP1 CRADD SMC1A CDKN1A CDC25C CDC25A CCNE1 MDM2-2 ABL1 MDM4 GADD45A CREB1 RAD50 RAD51 BID CDK2 CDK1 CCNB1 ATM TP53 RAD9A CASP2 MAPK9 JUN GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260810%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GRM5 GRM1 GRM3 GRM2 GRM4 GRM7 GRM8 CASR GPRC5B GPRC5A GRM6 GPRC5D GPRC5C GABBR2 GABBR1 NOTCH SIGNALING%WIKIPATHWAYS_20260810%WP61%HOMO SAPIENS Notch signaling HEY2 HDAC2 PIK3R2 FBXW7 HDAC1 PIK3R1 MTOR DLL1 DLL3 DLL4 AKT1 JAK2 CUL1 FHL1 SKP1 SNW1 HES1 HES5 SRC LCK JAG2 NOTCH2 APH1A NOTCH1 NCSTN APH1B GSK3B PSENEN ITCH MAML2 MAML1 CIR1 HES6 TLE1 RING1 NCOR1 SAP30 NUMB MAML3 NUMBL DTX1 MAGEA4;MAGEA1;MAGEA3;MAGEA2;MAGEA2B;MAGEA12;MAGEA6;MAGEA10-MAGEA5;MAGEA5;MAGEA9B;MAGEA9;MAGEA8;MAGEA11 SPEN JAG1 NFKB1 RBPJ ADAM17 NOTCH3 NOTCH4 NCOR2 PSEN2 STAT3 PSEN1 EP300 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome STK25 COPS8 ACKR3-2 RTP5 SNED1 GMEB1 PPP1R7 RNPEPL1 SEPTIN12 SH3BP4 ING5 EEF1A1 MAP1LC3C LRRFIP1 KIF1A ILKAP BOK AQP12B GPR35 ITPK1 DUSP28 OTOS GBX2 ARL4C MYOD1 IRF8 ATG4B USP40 ARF5 CENPA ASB18 CYTH2 CYTH4 GPC1 ITGB3 SPP2 PRLH CYTH1 FARP2 SEPTIN2 PDX1 SEPTIN6 MAB21L4 ARF1 MLPH CAPN10 PDCD1 SCLY RAB17 RAMP1 ASCL1 RBM44 ASB1 HES1 CYTH3 MYOG ABCA1 D2HGDH ILK PDGFA CXCL12 CALCA PRL EGFR MAP1LC3B2;MAP1LC3B-1 MAP1LC3A AGXT PER2 CFLAR COL6A3 HDAC4 CALCRL NFKBIA CXCL11 DTYMK RPS6 TNF NDUFA10 RAC1 TRAF3 IL1B TP53 JUN DISC1 MEF2A HES6 MEF2C DGKD UGT1A1;UGT1A6 TRAF3IP1 HDLBP HJURP ERFE KLHL30 CALM1 IL13RA1 GABARAPL2 PASK SEPTIN4-1 THAP4 CXCR4 RRAGA RRAGC RRAGB RRAGD GYS1 IQCA1 TWIST2 AGAP1 GABARAP HAMP COPS9-1 NEU4 ESPNL TRPM8 OR6B2 UBE2F MTERF4 RAB27A MYO5A KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260810%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 BDKRB2 BDKRB1 F12 SERPING1 KLKB1 CPN1 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260810%WP4815%HOMO SAPIENS Glycosaminoglycan degradation GLB1 HGSNAT HPSE2 IDUA HEXB HEXA NAGLU GNS SGSH GALNS HYAL1 HYAL2 HYAL4 IDS HPSE GUSB ARSB LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP5171%HOMO SAPIENS Leukotriene metabolic pathway PTGR1-1 ABCC1 LTC4S ALOX5AP DPEP1 LTA4H GGT1 DECR1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 GGT5 DPEP2 ALOX5 DECR2 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260810%WP2289%HOMO SAPIENS Drug induction of bile acid pathway NR1I3 SLC51A SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 SLC51B ABCC4 ABCC3 ABCB11 SLC10A1 NR1H4 BAAT CYP7A1 VDR NR1I2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCB1 SULT2A1-4 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260810%WP2882%HOMO SAPIENS Nuclear receptors meta pathway ACKR3-2 DNAJB1 CDKN1B BHLHE40 SLC7A5 TXNRD1 SLC6A13 FASN SMC1A CYP2C9;CYP2C19 ACADM VDR NR1I2 PPARA SLC6A6 PPARD SLC6A8 GADD45B SLC7A11 IRS2 SPRY1 SLC19A2 CDK4 CDK1 HES1 SLC5A5 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HSPA1A;HSPA1B CYP4F3;CYP4F2;CYP4F12;CYP4F11 FGF13 HSP90AB1 PTGR1-1 NR1I3 APOA2 GCC1 FTH1 APOA1 SLC6A18 SLC6A17 SLC6A16 SLC6A15 SLC6A14 SLC5A6 SLC5A7 POLK SLC5A8 SLC5A9 CES3 EPHA3 TGFA ABCB4 MGST3 SLC6A1 MGST1 HSP90AA1 MGST2 SLC5A2 CYP7A1 SLC6A20 SLC5A3 ABCG8 SLC5A4 ABCG5 SEC14L1 APOC3 PLK2 PRDX6 SLC6A5 SLC6A7 SLC6A9 CPEB4 SLC6A2 SLC6A3 EPB41L4B AKAP13 ENC1 PSMC5 EDN2 SLC2A11 IFNG SLC6A11 NCOA6 SLC2A10 TSC22D3 SLC2A13 MYOF SLC39A11 PRDX1 SLC39A10 SERPINB9 SLC39A13 SLC39A12 SLC39A14 CDC42EP3 EPHA2 AHRR PMP2 GPR153 SERTAD2 CBR3 CAVIN2 KTN1 GSTA4 RGS2 IL2 MYC SLC39A9 SLCO2B1 SLC39A6 BIRC2 EP300 SLC39A5 SLC39A8 BIRC3 PTGS2-2 SLC39A7 SLC39A2 SLC39A1 SLC39A4 SLC39A3 IGFBP1 SLC5A1-1 AIP TGFB2 SLC2A4 PGD SLC10A1 ALDH3A1 SCNN1A FKBP5 SLC26A2 ABHD2 IP6K3 FTL-1 DNAJC15 APOA5 GSTA3;GSTA1 PLTP SLC2A9 MAFF ALAS1 SRXN1 SLC2A5 SLC2A6 KAT2B SLC2A7 SLC2A8 G6PD ARL5B TGFBR3 SRGN GSTT2B;GSTT2 NAV3 ADGRF4 TNF PTGES3-1 SLC5A11 TGFBR2 SLC5A12 SLC5A10 RXRA PRRG4 STOM PPP1R14C TXNRD3 SERPINB2 PDE4B GSTM1;GSTM2-1 CCL13;CCL2 BAX B3GNT5 SRC ANGPTL4 CYP1A1 PTPA SLC2A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1B1 SLC6A19 JUN SREBF1 JUND POU5F1;POU5F1B NCOA2 NRG1 GSR TGFB1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 SCD NR1H3 UGT1A1;UGT1A6 AHR SMARCA1 GSTM4 STAT3 FGF19 CPT1A FGD4 PPARGC1A NR0B2 SNAI2 GPAM ARNT CES5A KLK15 CUL1 CES2 NRIP1 CES1 ABCB1 HMOX1 NCOA3 BLVRB FOXO1-1 MAFG ABCC4 LRRC8A CAP2 ZIC2 SULT2A1-4 KEAP1 NCOA1 CDKN1C JUNB HBEGF SLC2A12 CCL20 PDGFB SERPINA1 IL17B SP1 ESR1 AMIGO2 IL11 NR3C1 EGFR CCND1 HGF ACOX1 CYP1A2 PDK4 PCK1 GSTP1 GSTM3 IL12B BAAT IL12A SLC27A1 SLC6A4 EHHADH-1 SCP2 CPT2 ACAA1-1 CYP8B1 SOD3 FABP1 ETNK2 SLC27A5 CYP2A13;CYP2A6;CYP2A7-1 SQSTM1 GCLM ABCC3 ABCC5 NQO1 GCLC NFKB2 NFE2L2 MFGE8 TNFAIP3 ANKRD1 IL1B TXN CYP2B6 SRPX2 DNAJC7 GSTA3;GSTA5;GSTA1;GSTA2 DNER S100P ABCB11 NR1H4 ALOX5AP GGT1 CBR1-1 THBD AGER TNS4 FGFBP1 EGR1 SLC2A1 CDC37 ME1 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260810%WP531%HOMO SAPIENS DNA mismatch repair POLD3 POLD4 MSH2 RPA2 POLD1 POLE POLD2 RFC5 RFC3 RFC4 LIG1 RFC2 RPA1 MSH6 EXO1 RFC1 RPA3 POLE4 PMS2 MLH1 POLE2 POLE3 PCNA T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260810%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling PLCG1 GSK3A PDK1 CD28 GSK3B PTPN6 PTEN PPP3CA NFKBIA AKT1 CD8A CD8B;CD8B2 ITK CSNK1A1 NFATC2 NFKB1 PDCD1 CALM1 PRKCA DYRK2 CTLA4 ZAP70 DYRK1A LCK IL2 RASGRP1 FYN RASA1 AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260810%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis RPS6KB1 MLST8 PRKAG1 PRKAG2 PRKAA1 PRKAG3 TSC2 CSN2-1 PRKAA2 MTOR PRKAB2 EEF2 PRKAB1 CSN3 EIF4A2 CSN1S1 EIF4G1 RPTOR EIF4E EEF2K TRANSLATION FACTORS%WIKIPATHWAYS_20260810%WP107%HOMO SAPIENS Translation factors EEF1G EIF2AK3 EEF1D EEF1A2 ETF1 EIF6 EEF1A1 EIF2B5 EIF2S2 EIF2S3;EIF2S3B EIF2S1 EIF4EBP1 EIF1 EIF3C;EIF3CL EIF5 EIF4A2 EIF4EBP2 EIF2AK2 EIF1AY;EIF1AX EIF4A1 EIF3I EIF4E EIF3J EEF2K EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF4B EIF3B EIF2B2 EIF4G3 EEF2 GSPT2 EIF4G1 EIF4H EIF2B1 EEF1B2-1 PAIP1 EIF2B4 EIF5B PABPC1;PABPC3 EIF2B3 CLUH EIF2AK1 EIF5A;EIF5AL1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260810%WP455%HOMO SAPIENS GPCRs class A rhodopsin like ACKR3-2 LPAR5 CCR8 GPR35 HTR2A CHRM1 ADRA2C ADRA2B ADRA2A SSTR1 SSTR2 F2R CNR1 FFAR1 PTGER4 PTGER1 PTGER2 PTGER3 CXCR2 GPR83 FFAR2 GPR68 NMBR LPAR4 P2RY6 MC1R P2RY4 MAS1 FSHR P2RY2 ADORA3 P2RY1 ADORA1 CHRM3 P2RY12 P2RY13 ADRA1D P2RY10 P2RY11 P2RY14 GRPR ADORA2A EDNRA ADORA2B OR2B6;OR2B2-1 LPAR6 CCR5 BDKRB2 BDKRB1 OR1F1 OR2H1-1 AGTR1 AGTR2 CCKBR OR1E1;OR1E2 FPR2 OR10A5 OR3A1 LTB4R PTGFR CMKLR1 C5AR2 NPFFR2 OXTR OR2A7;LOC107987545;OR2A4 NPFFR1 RRH GPR174 GPR173 CXCR3 EDNRB GPR171 PTGDR GPR37L1 NTSR1 TRHR GPR17 GPR161 HTR1F OR7A10;OR7A17-11 OR2F1-2 OR2AG1;OR2AG2 FPR1 OR1I1 MC2R GALR3 GALR2 NPBWR1 GALR1 GPR18 NPBWR2 OR6B1 CCR10 MC3R NTSR2 CCR1 GPR15 XCR1 GPR12 HCAR2;HCAR3 OR6A2 GPR19 GPR27 GPR25 PTGDR2 GPR21 GPR22 GPR20 NPY4R2;NPY4R OR10H1;OR10H5;OR10H2 BRS3 CCKAR CCR9 CXCR4 NPY2R CCR7 CCR6 CCR4 GPR39 GPR37 GPR34 AVPR1B GPR32 OR1A1-1 AVPR1A MTNR1A OR2S2-1 MTNR1B ADRB3 OR3A2 OPRD1 GPR45 PTAFR CHML GPR52 DRD1 GPR1 DRD3 OR8D2-1 DRD4 GPR50 GPR4 OPN4 GPR3 OPN3 GPR6 MC5R F2RL1 F2RL3 OR1C1 CHRM4 GPR65 CHRM5 GPR63 CYSLTR1 CCRL2 OR2D2 LHCGR NPY1R OR2T1 OPRL1 APLNR OR5V1-2 OR2C1 SUCNR1 OR5I1 GPR85 HCRTR2 MCHR1 OR1Q1 HCRTR1 HRH1 HCAR1 HRH3 HRH2 OR2B3 DRD5 HTR1E HTR1D HTR1B OR2J1;OR2J2;OR2J3-2 NMUR2 NMUR1 OR14J1 MLNR HTR2B ADRA1B ADRA1A GPER1 OR7C1;OR7C2-9 PRLHR PTGIR NPY5R OR2H2 AVPR2 OPRM1 SSTR3 SSTR4 SSTR5 OR10A4 CX3CR1 F2RL2 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW CNR2 OR8B8 OR2W1 OR12D3 OR1D2 OPRK1 HTR5A OR10J1-2 OPN1SW ACKR4 ACKR2 OR11A1 CYSLTR2 CCR3 CCR2 CXCR1 GHSR MC4R DRD2 ADRB1 ADRB2 RHO TBXA2R CXCR5 C3AR1 CHRM2 GPR75 GPR87 FFAR3;GPR42 HTR4 HTR6 HTR7 HTR1A BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260810%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders DPYS NT5C TYMP TK2 NT5C3A PUS1 RRM1 CKB UPB1 TYMS DHODH DPYD UMPS RRM2-1 RRM2B PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260810%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling HIF1A PTGS2-2 SLC16A1 PDHA1 IGFBP1 MCL1 EPO BNIP3L IGFBP3 PFKL HIF1AN BNIP3 PKM IGFBP2 ANGPT1 ARNT TGFA EDN1 ANGPT2 BAK1 NOS2 TGFB3 PGK1 PMAIP1 VEGFA BIRC5 BID SERPINE1 TP53 SLC2A1 BAX BCL2A1 BCL2L1 HK1 LDHA EGLN1 SERINE METABOLISM%WIKIPATHWAYS_20260810%WP4688%HOMO SAPIENS Serine metabolism PSAT1 SHMT2 DHFR2;DHFR SHMT1 PHGDH PSPH SRR TYMS MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260810%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes MATN1 COL9A3 COL9A2 MATN3 COMP COL9A1 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260810%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies RB1 DICER1 TGFB2 HDAC1 CTSK CDKN1A MYOD1 AGO2 KAT2B MSTN CREBBP E2F1 TNFRSF11B TARBP2 CDK4 HES1 HES5 HMGA2 EMD TMPO LEMD3 TCF7L1 JUNB SPP1 SREBF1 APC NOTCH1 TCF7 GSK3B MAOB MAOA CEBPA WNT10B CEBPB NAP1L1 CEBPD TLE1 WNT7B ICMT TGFB1 CSNK1A1 AXIN1 ZMPSTE24 FNTA LMNA LEF1 SMAD2;SMAD3 PPARG TCF7L2 BMP2 ACTB-1 CTNNB1 RUNX2 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260810%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport ALDH1L1 FOLR1 MTR-1 FTCD TYMS MTHFD1 SLC19A1 MTHFR MTHFD2 ST20-MTHFS;MTHFS QDPR MTHFD2L SLC46A1 SHMT2 ALDH1L2 DHFR2;DHFR SHMT1 ATIC GART IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260810%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NUBP2 NFU1 NFS1 LYRM4 FDX1 FDXR CIAO2B FXN ISCU HSPA9 NARF ABCB7 GLRX5 HSCB NUBP1 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260810%WP5050%HOMO SAPIENS TCA cycle in senescence TP53 PDK1 PDHA1 FH MDH1 PDP2 ME2 ME1 BRAF GOT1-1 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway JUNB CDKN1B IGFBP1 JUND AIP ALDH3A1 SLC7A5 NQO1 POLK IL17B NFE2L2 ARNT CES3 MGST1 HSP90AA1 EGFR CYP1A2 PTGES3-1 TNF TGFB1 UGT1A1;UGT1A6 IFNG SERPINB2 MYOF IL1B HES1 AHR IL12B BAX AHRR SRC IL12A GSTA3;GSTA5;GSTA1;GSTA2 CDC37 CYP1A1 CAP2 IL2 CYP1B1 EP300 NCOA1 JUN HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260810%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias HMBS CPOX PPOX ALAS1 ALAD ALAS2 FECH UROD UROS NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260810%WP4753%HOMO SAPIENS Nucleotide excision repair ERCC5;BIVM-ERCC5 GTF2H1 POLE GTF2H3 POLD2 GTF2H4 XPC ERCC3 MNAT1 RFC1 ERCC2 CUL4B PCNA CUL4A POLD3 DDB2 POLD4 DDB1 RPA2 POLD1 RFC5 CDK7 RFC3 RFC4 LIG1 RFC2 RPA1 ERCC4 RPA3 RBX1 POLE4 CETN2 ERCC1 XPA RAD23A ERCC8 ERCC6 POLE2 GTF2H2C;GTF2H2C_2;GTF2H2 RAD23B POLE3 CCNH NOTCH SIGNALING%WIKIPATHWAYS_20260810%WP268%HOMO SAPIENS Notch signaling MFNG NOTCH2 HDAC2 APH1A NOTCH1 CTBP2 NCSTN APH1B HDAC1 DVL1 DVL2 DVL3 DLL1 DLL3 DLL4 DTX3L MAML1 KAT2B CREBBP NUMB MAML3 NUMBL DTX1 JAG1 RBPJ CTBP1 HES1 HES5 ADAM17 NOTCH3 NOTCH4 RBPJL PSEN2 NCOR2 DTX2 DTX3 RFNG DTX4 LFNG INPP5K JAG2 PSEN1 PTCRA KCNJ5 KAT2A IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260810%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease TNF STAT5A STAT5B IFNG IL17F STAT4 RORC IL12B CSF2 IL23A STAT1 IL17A IL22 STAT3 JAK2 TLR4 TYK2 IL12RB1 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260810%WP5175%HOMO SAPIENS Disorders in ketone body synthesis HMGCL BDH1 OXCT1-1 ACAT1 HMGCS2 NEPHROGENESIS%WIKIPATHWAYS_20260810%WP5052%HOMO SAPIENS Nephrogenesis NOTCH2 WNT9B JAG1 OSR1 GREB1L TCF21 RSPO3 RSPO1 FOXD1 FGF20 WNT4 FGF8 PAX2 BMP7 MEIS1 WNT3A ALDH1A2 SIX2 AUTOPHAGY%WIKIPATHWAYS_20260810%WP4923%HOMO SAPIENS Autophagy AKT1S1 PRKAA1 UVRAG MTOR WIPI2 RPTOR PIK3C3 DEPTOR RB1CC1 PIK3R4 MLST8 PRKAG1 PRKAG2 MAP1LC3B2;MAP1LC3B-1 ATG3 BECN1 PRKAG3 ATG12-1 ATG9A ATG13 AMBRA1 ATG5 PRKAA2 ATG101 PRKAB2 ATG7 PRKAB1 ATG16L1 ULK1 ATG14 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260810%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein GSK3A MCL1 GSK3B PTHLH AKT2 BCL2L12 AKT3 BCL2L13 BCL2L10 BID BOK BCL2L14 ITGA6 BCL2L15 BCL2 BAX BAK1 BCL2A1 AKT1 BCL2L1 MYC PIK3CG ITGB4 BCL2L2 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260810%WP4725%HOMO SAPIENS Sphingolipid metabolism overview CERK SGMS1 GBA SGMS2 GBA2 UGT8 UGCG SGPL1 SMPD1 KDSR CERS3 CERS4 CERS6 SGPP2 SGPP1 DEGS1 DEGS2 CERS1 CERS2 PLPP3 PLPP2 PLPP1 ASAH1 SPTLC1 SPHK2 SPHK1 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260810%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 TMPRSS2 ACE2 CTSV;CTSL NOX1 NFKB2 MAVS IKBKE IFIH1 DDX58 CGAS ECSIT ACAD9 NFKB1 NDUFAF1 NLRX1 IRF3 TRAF3 STING1 TRAF6 TBK1 BCS1L IRF7 ACE TLR7 AGTR1 REN AGTR2 TLR3 TOMM70 PHB TICAM1 NDUFB9 PHB2 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260810%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming KLF4 TRIM71 POU5F1;POU5F1B EGR1 MYC SOX2 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260810%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRB RXRA RARA RXRG RARG RARB SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260810%WP3944%HOMO SAPIENS Serotonin and anxiety related events PRKCB CRH HTR2A PLCD4 CRHR1 NLGN1 FOS PLEK GRIN2D ARC PPP3CA HTR1A HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260810%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 TCF4 ZBTB16 SMAD1 EGR2 NFATC1 GLI2 MSX1 BMPR1A SMAD4 IGFBP5 CCN2 FOS HR HOXC12 FOXQ1 CASP14 SOSTDC1 CD34 PHLDA1 SPINK6 SPINK5 KRTAP3-2;KRTAP3-3-1 GTPBP4 DKK3 ADAMTS20 SFRP1 DSG1 GAS1 S100A4 DSG4 DLX3 KLK5 KLK4 KLK7 KLK6 CUX1 JUN DKK4 WIF1 LRIG1 GSDMA NOTCH2 BCL11B KRTAP8-1 KLK13 NOTCH1 KLK14 FOXN1 KRT19 GJB6 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 PERP LGR5 CD200 FZD1 DSC2 GPRC5D NR3C1 EGFR TP63 FST SOX2 WNT5A RUNX3 FOXE1 DKK1 IGF1 IFNG NFKB1 BMP4 RBPJ LEF1 KITLG FOSB ELANE SOX9 MSX2 GATA3 ADAM17 PROM1 BMP6 KRT15 CTNNB1 LHX2 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260810%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia PRKCG ATP2B2 PDK1 GRM1 TRPC3 GNA14 GRIA1 RYR3 HOMER3 GRIA2 CA8 GNA15 PLCB3 PLCB4 GNAQ GRIA3 GRIA4 GNA11 PLCB1 CACNA1A PLCB2 ITPR1 G PROTEIN SIGNALING%WIKIPATHWAYS_20260810%WP35%HOMO SAPIENS G protein signaling PRKCG PRKCB AKAP8 GNG13 GNB3 GNGT1 PDE8A SLC9A1 GNAZ KRAS GNA15 PRKACA-1 HRAS GNA11 PRKACB-1 PRKCD GNAL ADCY4 ADCY3 ADCY2 AKAP5 ADCY1 GNAO1 ADCY8 ADCY7 PRKAR1A ADCY6 PDE4B GNAI3 PDE4A GNAI1 ADCY5 NRAS PDE8B PRKCA GNAI2 PDE4C PPP3CC RHOA PDE1C PLCB3 PDE1B GNB2 PDE1A GNA13 GNB1 ADCY9 GNA12 GNAQ ARHGEF1 PDE4D-1 ITPR1 PRKCI PRKCH PRKCE PDE7B PRKCQ GNG5 PRKCZ PDE7A GNG4 GNG8 PPP3CA GNA14 AKAP9-1 AKAP12 AKAP10 AKAP11 PRKD3 AKAP7 AKAP6 AKAP4 AKAP3 AKAP1 PRKD1 KCNJ3 AKAP13 PRKAR1B CALM1 GNAS-1 PRKAR2B PRKAR2A RRAS GNB5 GNG10 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260810%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals EPHB2 SLC7A11 GCLM AIMP2 NQO1 PRKCA GCLC PIK3CA NFE2L2 CEBPB GSTA3;GSTA5;GSTA1;GSTA2 MAF MAPK8 HMOX1 KEAP1 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260810%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism ALDH7A1 FMO3 CHDH SLC44A1 SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260810%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway ESR1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 HSD17B3 ESR2 CYP19A1 HSD17B1 HSD17B2 HSD3B1;HSD3B2 SLCO4A1 SLCO2B1 SLCO4C1 SLCO1A2 SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260810%WP4658%HOMO SAPIENS Small cell lung cancer BIRC3 PTGS2-2 RB1 CDKN1B PIK3CD TRAF1 PIK3R3 ITGA2 E2F3 PIK3R2 PIK3CB PIK3R1 ITGB1 PIK3CA ITGA6 NFKBIA BCL2 CDKN1A AKT1 CCNE2 MAX CCNE1 APAF1 SKP1 E2F1 CASP8 DDB2 ITGAV TRAF2 RXRB GADD45B GADD45A CASP3 COL4A6 LAMA2 RXRA LAMA1 LAMA3 GADD45G LAMC2 LAMB3 CDK6 AKT2 CYCS-1 LAMB1 AKT3 TRAF3 CDK4 BID CDK2 TRAF6 TP53 PTK2 NFKBIB BAX LAMC3 RELA CDKN1C TRAF4 TRAF5 CASP9 IKBKB POLK PTEN RARB IKBKG ITGA3 E2F2 BAK1 CDKN2B CHUK NOS2 COL4A4 COL4A3 COL4A5 CCND1 CKS1B CKS2 BIRC7 LAMA5 FHIT ZBTB17 LAMB4 NFKB1 ITGA2B LAMB2 LAMA4 FN1 LAMC1 BCL2L1 COL4A2 RXRG COL4A1 MYC BIRC2 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome ZNF830 CCL3L1;CCL3L3;CCL3;CCL18 CCL14 SLFN5 GGNBP2 ACACA FBXO47 MLLT6 FBXL20 NEUROD2 CCL8 MIEN1 ZNHIT3 C17orf78 CCL1 ASIC2 RFFL SOCS7 LHX1 GAS2L2 CCL16 HEATR9 TMEM132E TAF15 RASL10B PCGF2 SYNRG PEX12 EPOP MYO19 PLXDC1 NLE1 ARHGAP23 TADA2A TEC STAC2 SLFN12L;SLFN12-1 CDK12 TCAP CCL23;CCL15 CCL13;CCL2 DUSP14 PPP1R1B CCL4L2;CCL4L1;CCL4 PGAP3 CCL5 PIGW GRB7 PNMT CACNB1 HNF1B PIP4K2B ERBB2 MMP28 DHRS11 SLC35G4;SLC35G5;SLC35G3;SLC35G6 CWC25 AP2B1 SLFN11;SLFN13 AATF IKZF3 CISD3 CCL11 CCT6B RDM1 LASP1 ARL5C C17orf98 C17orf50 GPR179 MED1 STARD3 UNC45B RPL23 LIG3 LYZL6-1 DDX52 MRPL45 SRCIN1 FNDC8 RAD51D SLFN14 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260810%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism LPL DGAT1 ADH1C;ADH1B;ADH1A RBP4 RARB MAPK1 NPC1L1 ABCG8 CD36 ABCG5 ALDH1A3 ALDH1A2 ALDH1A1 CYP2E1 RPE65 SDR16C5 RXRB RDH12 CRABP2 AWAT2 RDH8 RXRA RETSAT CRABP1 LRAT RLBP1 RARA ADH4 BCO1 CYP26B1 BCO2 DHRS3 SULT2B1 CYP26A1 RBP7 RBP2 RBP1 RDH5 RDH10 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 RXRG RARG SCARB1 INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260810%WP1984%HOMO SAPIENS Integrated breast cancer pathway RB1 MRE11 SMAD1 BRCA1 TSC2 TSC1 PIK3R2 CHEK2 CHEK1 MTOR KRAS CDC25A MAPK1 AKT1 MYT1 BMPR1A NF1 MDM2-2 IRS1 SMAD4 STK11 E2F1 ABL1 NCOA3 FOXO1-1 PIAS1 GADD45A CREB1 MAP3K13 PML RAD50 RAD51 CDK4 CDK2 ATM NAB1 MAP3K7CL RAP1A ATR ZMYND8-1 ZMIZ1 ALKBH1 JAKMIP1 RPP38 RALGAPA1 PPP4R3A PPP4R3B CCNB1IP1 CDC25B EDAR BLM MYCBP2 SMARCA4 PLK3 ERAL1 FOSL2 MSH2 FER PKIA NOXA1 ZNF655 PIGR DAG1 USP38 GDI1 DHTKD1 NUP85 BRCA2 CASP9 IMPA1 TPR RASGEF1A SP1 ANXA1 DCAKD ITPKC ESR1 USP15 USP16 SELENOK RAD54L BAK1 HIPK2 USP21 WEE1 FILIP1 FAU EGFR CCND1 SMAD7 VEGFA CTNNB1 CDC42 PAK1 ARAF MYC PHB EP300 FADD HDAC1 XRCC3 PLK1 BRAF SMAD6 CERK BCL2 MAX TAB1 RHEB BARD1 TRADD CASP8 TGFBR2 CASP3 RAC1 GRN SIRT1 ODC1 BID MSH6 BAD RHO TP53 BAX AURKA RALA-1 JUN GSK3A CSNK1D TFPI TGFBR1-1 PTEN CHUK FOSL1 BACH1 AR NFKB1 CDK7 SMAD2;SMAD3 ATF1 AHR JAK1 BMPR2 STAT1 MMP1 HMGCR CYP19A1 RASGRP3 RRAS CDH1 UBE2F NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260810%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer CDKN1B SLC39A4 TGFB2 BCAR1 SNAI2 MAP2K2;MAP2K1 NFKB2 FLT1 CHD2 MET MAPK1 AKT1 CCNE2 CCNE1 MAPK3 TGFBR3 SMAD4 MMP9 CDH5 TGFBR2 KDR CCN2 RAC1 AKT2 AKT3 CDK2 PTK2 SRC RELA GSK3A COL1A1 SEMA3A TGFBR1-1 PLXNA1 EGFR PLXNA4 TGFB3 HGF EGF VEGFA NFKB1 SMAD2;SMAD3 PECAM1 NRP1 CHD1 RELB COL1A2 MMP2 PLXNA2 REL SNAI1 MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis GPHN AOX1 MOCS2 MTARC2 SUOX MOCS1 XDH PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260810%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 FBXO32 TRIM63 VEGFA PPARGC1A ESR2 MYF5 RET PAX7 CDKN1A MYOD1 MYOG UPF1 ADRB2 MYC EP300 DUX4;DUXA SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260810%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction ACE2 NOX1 MAVS NLRP3 IL18 RPS6KA1 TNF NDUFAF2 TERF2IP ECSIT ACAD9 NFKB1 NDUFAF1 NLRX1 IL6 SIRT6 TRAF3 STING1 TRAF6 BCS1L ACE AGT REN TOMM70 PHB TERF2 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260810%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis CEBPG KLF15 SREBF1 EGR2 DDIT3 PPARG GATA3 KLF2 GATA2 CEBPA CEBPB CEBPD KLF5 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260810%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia BCL2 TP53 ZAP70 MCL1 RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260810%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CYP11B1;CYP11B2 CYP21A2 ATF2 ATF4 CAMK2A CAMK2D CMA1 CAMK2B CTSG CREB3 CREB1 CAMK2G CAMK1D CAMK1 CAMK1G CREB5 ATF6B CALM1 ATF1 CALM3;CALM1 CALML6 CALML3 CALML4 CALM2 ACE AGT CAMK4 AGTR1 GNAQ ITPR2 REN AGTR2 CREB3L3 ITPR3 CREB3L4 PLCB2 ITPR1 CREB3L1 HSD3B1;HSD3B2 CREB3L2 STAR CYP11A1 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260810%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging FOXO1-1 HIF1A NFKB1 TFAM-1 ROS1 PPARG FOXO3 SIRT1 PARP1 SIRT3 NAMPT INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260810%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IL12RB2 NOD2 IL17F IL2RG NFATC1 IL5 RORA IL18 IL13 MAF TNF TGFB1 FOXP3 NFKB1 IFNG HLA-DMA IL6 IL18RAP SMAD2;SMAD3 IL10 TBX21 IL23R IL21R STAT4 GATA3 RORC IL1A STAT6 IL12A IL4R IL23A IL21 STAT1 IL22 TLR5 STAT3 TLR4 TLR2 IL2 IL4 IFNGR1 IL12RB1 JUN MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260810%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies S1PR3 S1PR5 ITGA4 S1PR4 MS4A1 ITGB1 BTK S1PR1 KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260810%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence FOXO1-1 TNF IFNB1-4 IFNG AADAT HAAO IL1R2 QPRT AHR TP53 CDKN1A EIF2AK4 NOS1 KMO ACMSD TDO2 KYNU AFMID IDO2 TLR4 IDO1 KLF5 CAT EIF2AK1 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260810%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions SOCS3 OLIG1 OLIG2 CCR8 CCL1 CNP OSM MOG IL10RB PDGFRA IL10RA ITGB3 FOXO1-1 SSTR2 ITGAV PDCD1 PTK2 HEXB CTLA4 PLP1 CX3CR1 FOXO3 IL12RB1 IL12RB2 CD4 CD28 LGALS3 CCL20 PDGFA CASP1 NLRP3 CXCL12 NOS2 FAM20C ROS1 IL18 EGFR LGALS1 FOXP3 VEGFA IFNG IL6 CD86 CD80 IL12A CDC42 CXCL2;CXCL3;CXCL1-1 IKZF2 CCN3 IL2 TGM2 NKX6-2 CD274 EBI3 APOD NKX6-1 GSDMD MCAM TMEM119 STAT5A CSPG4 STAT5B CD47 SEMA3F TGFB2 ITGA2 AIF1 KLRG1 IL2RG IL33 GALC TNFRSF1B CD68 NFKB2 IL2RA IL2RB MYD88 SIRPA;SIRPB1;SIRPG JAK3 TGFBR3 TYK2 P2RY12 TNF MMP9 TGFBR2 RAC1 IL10 STAT4 IL1B TLR4 MAPK14 IL1RAP SPP1 TGFBR1-1 AREG TGFB1 IGF1 NFKB1 CD44 SMAD2;SMAD3 SOX9 CCR6 HTR7 FOXO4 JAK1 MBP STAT1 IGF1R STAT3 NKX2-2 IL4 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260810%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms ACE TMPRSS2 AGT AGTR1 MAS1 ACE2 REN CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway NR1I3 CYP2A13;CYP2A6;CYP2A7-1 PPARGC1A ABCC3 SP1 SMC1A HSP90AA1 CYP2C9;CYP2C19 ALAS1 NCOA2 ABCB1 FOXO1-1 ABCC2 RXRA UGT1A1;UGT1A6 NCOA6 CYP2B6 DNAJC7 GSTA3;GSTA5;GSTA1;GSTA2 EHHADH-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 PTPA CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SULT2A1-4 NCOA1 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260810%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection PDE3A XIAP GRIN2C GRIN2D CASP9 NPPB NPPA CNGA1 CNGA2 NFKBIA CNGA3 BCL2 AKAP9-1 CNGA4 GRIN2A CNGB3 CNGB1 NOS2 DLG4 GUCY1B1 NOS3 NPR1 CAMK2A CAMK2D GRIN2B TNF CAMK2B PRKG2 CREB1 CAMK2G NFKB1 IFNG ACTN2 CALM1 CYCS-1 GUCY1A2 IL1B TSPO GUCY1A1 NEFL BAD NOS1 PPID GRIN1 PDE2A RELA EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260810%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PTGR1-1 PTGS2-2 PTGFR PTGIS PTGDR PLA2G5 PLA2G6 PRXL2B JMJD7-PLA2G4B;PLA2G4B HPGD AKR1B1 PTGDS PTGR2 ACOX2 ACOX3 PTGES PPARD ACOX1 PTGDR2 PPARG PTGIR EHHADH-1 TBXA2R TBXAS1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PTGS1 ACAA1-1 PLA2G4A PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260810%WP4917%HOMO SAPIENS Proximal tubule transport ATP6V1G1 SLC5A1-1 SLC34A1 SLC1A1 ATP6V0E2;ATP6V0E1 SLC22A7 ABCG2 SLC4A2 SLC4A4 AQP1 CA2 CA4 ABCB1 ATP6V1E1 SLC22A11 ATP6V0B SLC13A3 SLC36A2 ATP1B1 SLC7A8 ABCC4 SLC7A9 ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V1A SLC22A6 SLC47A1 SLC20A2 SLC22A2 SLC3A1 SLC3A2 ATP1A1 SLC5A5 CLTRN SLC12A4 ATP6V1H ATP6V0A4 ATP6V1D SLC16A10 FXYD2;FXYD6-FXYD2 SLC22A8 SLC2A2 SLC26A6 SLC6A19 SLC6A18 SLC5A8 SLC5A2 SLC6A20 SLC9A3 ATP6V1C1 ATP6V1F ABCC2 SLC2A1 SLC7A7 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP23%HOMO SAPIENS B cell receptor signaling GTF2I PRKCB ATF2 PIK3R2 PIK3R1 NFATC3 MAP2K2;MAP2K1 BRAF NFKBIA GRB2 MAPK1 AKT1 MAX GAB1 RAF1 MAP2K6 HRAS CAMK2A SHC1-1 RPS6KA1 PIK3CG BCL6 PRKCD GAB2 TEC FOXO1-1 SYK CREB1 SOS1 RAC1 ELK1 MAPK4 LCK BLNK KLF11 CARD11 LAT2 BCL10 HCLS1 INPP5D DAPP1 MALT1 CD79B FYN RELA CD79A PLCG2 MAPK9 CD19 JUN SH3BP2 PLCG1 GSK3A PTPN18 PTPN11 CR2 MAPK14 PIK3AP1 PTPRC CD22 CRK PIP5K1A GSK3B NCK1 PTPN6 IKBKB IKBKG MAP3K7 CD81 MAP4K1 CHUK PDPK1 MAPK8 LYN CBL NFATC2 PIP5K1B NFKB1 PIP5K1C ETS1 RAPGEF1 CDC42 CRKL RASGRP3 VAV1 MYC VAV2 REL BTK BLK MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260810%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways GNG13 ACKR3-2 DGKZ GNB3 GNGT1 YWHAE RYR2 RGS16 CRH YWHAG YWHAH ACTC1;ACTG2 ACTG1 IGFBP5 SFN ADCY4 ADCY3 ADCY2 ADCY1 CREB1 ADCY8 ADCY7 ADCY6 ADCY5 RAMP1 MYL4 ACTA1 MYL2 GNB2 PLCB3 GNB1 ADCY9 GNAQ GNB4 PLCD1 GABPB1 ITPR1 PLCG2 PLCG1 GABPA PKIA GNG2 GNG5 GNG4 IGFBP3 GNG8 IGFBP2 SP1 RYR3 CALCA OXT-1 NOS3 RGS10 CAMK2B GJA1 CAMK2G IL6 CALM3;CALM1 CALM2 NOS1 ACTB-1 ITPR2 RYR1 RGS2 ITPR3 PRKCG PRKCB ATF2 ATF4 IGFBP1 ATP2A3 ATF3 ARRB1 CRHR1 ARRB2 YWHAB MAFF YWHAQ PRKACA-1 GRK6 CAMK2A PRKACB-1 PRKCD YWHAZ CREB3 RXFP1 FOS PRKAR1A ADM ATF6B PDE4B PRKCA IL1B GUCY1A1 LPAR1 RGS14 PDE4D-1 PRKCH JUN PRKCE CRCP PRKCQ ATF5 OXTR RXFP2 RGS4 RGS5 RGS3 RGS1 PRKCZ RGS9 RGS6 RGS7 IGFBP4 CNN2 CACNB3 CNN1 GRK5 GRK4 CALD1 IGFBP6 PKIB GPR182 PKIG GSTO1 RGS18 RGS17 PRKD1 RAMP2 CAMK2D RGS19 RAMP3 SLC8A1 RLN2;RLN1 RGS20 CORIN GUCA2B GUCA2A RGS11 PRKAR1B NFKB1 ETS2 CALM1 ATF1 GNAS-1 ATP2A2 PRKAR2B PRKAR2A ACTA2 MYLK2 GNB5 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260810%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation TGFBR1-1 PDGFA INS;INS-IGF2 BRAF FLT1 KRAS FOXM1 MAPK1 AKT1 CRTC2 MAPK3 SMAD7 FOXO1-1 PDX1 PGF DLK1 IGF1 RASSF1 AKT2 AKT3 CDK4 CDK2 IGF1R INSR MYC TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260810%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 ACTL6A GLI1 RB1 GLI2 EZH2 CDKN2A GLI3 SMARCB1 RBBP4 SMARCD1 SMARCD2 SMARCD3 GLI4 DPF1 DPF2 CDK6 DPF3 SMARCE1 SUZ12 SMARCC1 CDK4 SMARCC2 EED PTCH1 ARID1B ACTL6B SMO ARID1A H3-3A SMARCA4 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260810%WP4742%HOMO SAPIENS Ketogenesis and ketolysis UCP2 SLC25A20 BDH1 SLC2A1 SLC16A1 OXCT1-1 ACAT1 CPT2 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260810%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 CHOLESTASIS%WIKIPATHWAYS_20260810%WP5238%HOMO SAPIENS Cholestasis NR1I3 ABCC2 RXRA ABCC4 ABCC3 ABCB11 SLC10A1 LDLR NR1H4 ABCB4 ATP8B1 SLC22A1 ABCG8 HMGCR ABCG5 TJP2 EPHX1 SCARB1 SLCO1A2 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260810%WP2646%HOMO SAPIENS Lidocaine metabolism CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1A2 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260810%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis CYB5A HSD17B6 SRD5A2 HSD17B3 CYP17A1 POR HSD3B1;HSD3B2 STAR CYP11A1 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260810%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways ACOT4 SLC27A5 DBP CYP7A1 NPC1-1 ACOX2 NPC2 EBP ACOT2;ACOT1 CYP27A1 DHCR7 BAAT SCP2 THEM5 ACOT9 ACOT8 EPHX2 ACOT7 HSD11B1 ACOT11 HSD11B2 ACOT12 ACOT13 AMACR ACOT6 SLC27A2 QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260810%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis MAFK PTGS2-2 CYP2A13;CYP2A6;CYP2A7-1 VEGFA MAFG FOS NFKB1 IKBKB NFE2L2 NFKBIA NOS1 MMP1 ACOX2 JUN KEAP1 FOXA2 PATHWAY%WIKIPATHWAYS_20260810%WP5066%HOMO SAPIENS FOXA2 pathway MTTP FOXO1-1 SLC27A5 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 ACACA SREBF1 ABCC4 IRS2 ABCC3 APOB FOXA2 INS;INS-IGF2 FASN GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA3;GSTA5;GSTA1;GSTA2 FOXA1 PPARGC1B IRS1 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260810%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection ARPC1B TUBB3;TUBB6 ARPC1A ARPC5L LY96 TUBA3E;TUBA3C-1 ARPC4 ARPC5 KRT18 TUBB4A;TUBB;TUBB8B;TUBB8 ARPC2 NCK2 ARPC3 TUBA8 WAS NCK1 EZR CD14 TUBB2B;TUBB2A ITGB1 TUBAL3 TUBA1C ROCK2 YWHAQ ARHGEF2 ACTG1 ABL1 YWHAZ TUBB4B ROCK1 NCL-1 OCLN-1 PRKCA TUBB1 TUBA4A RHOA TUBA1A ACTB-1 WASL CTNNB1 CLDN1 CDC42 TLR5 TLR4 CTTN HCLS1 CDH1 FYN METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260810%WP5355%HOMO SAPIENS Metabolic epileptic disorders CTH ACAT1 PDHA1 CDO1 MDH1 GLUD1;GLUD2 SLC2A4 MOCS3 PFKL GLDC PKM MPC1 ECHS1 MPC2 SLC25A5 AASS GAMT PGAM1 PGAM2 DLD ETHE1 SPCS1 GAPDH-1 FBP1 HADH FBP2 SLC7A2 SLC2A5 SQOR GATM LDHAL6B PGK1 ALDOC ENO1 SLC25A1 ALDOA MDH2 HK3 GCK PHGDH PSPH SLC2A2 PFKM GCDH PSAT1 ALDH7A1 PC BTD HLCS ENO2 ENO3 DHTKD1 TPI1 PKLR ALDOB GPHN LDHA;LDHC PFKP ARG1 MOCS2 ASS1 SLC25A15 SUOX MOCS1 LDHB XDH CPS1 ASL PCK1 OTC CBS;CBSL GPI GOT1-1 AADAT GOT2-1 AMT GLS2 SLC2A1 GPT ACO1 SLC1A5 SHMT2 HK2 SHMT1 HK1 SFXN1 LDHA DLAT G6PC1 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260810%WP170%HOMO SAPIENS Nuclear receptors NR1I3 HNF4A NR2F2 NR2F6 NR4A1 THRB RARB ESR1 RORA VDR NR1I2 ESRRB NR3C1 PPARA THRA PPARD NR2E1 NR2C2 ESRRA NR1H2 NR2F1 NR0B1 NR4A2 NR5A1 RXRB AR NR5A2 ROR1 RXRA NR1H3 ESR2 RARA PPARG RORC PGR NR1D2 RXRG RARG ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260810%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy ETHE1 TST SUOX PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260810%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 TNF BIRC3 TRAF2 CASP3 RIPK3 RIPK1 CYCS-1 FADD CASP9 CASP7 BAX TNFRSF1A PPP2CB;PPP2CA TRADD CASP8 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260810%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling PRKCB IFNAR1 SOCS3 IL5RA F2RL3 OSMR IL2RG MTOR IL2RA IL2RB MAPK1 RPTOR CSF3R LIFR TRIM28 JAK2 JAK3 MAPK3 PDGFRB CREBBP IL10RB PDGFRA MAPKAP1 IL10RA DEPTOR TYK2 RICTOR MLST8 F2R PTPRT CNTFR SETD7 MPL IL27RA DUSP2 STMN1 IL9R CSF2RA IFNLR1 MAPK15 IL22RA1 PTPRD MAPK6 SRC MAPK4 AGTR1 IL7R AGTR2 F2RL2 GHR IFNGR1 IFNGR2 MAPK9 AKT1S1 IL12RB2 MAPK14 PTPRC IL3RA MAPK12 MAPK13 MAPK10 MAPK11 PIAS3 IL11RA IL6ST IL6R EGFR CSF2RB MAPK8 MAPK7 CTF1 IL21R IL20RA IL20RB JAK1 IFNAR2 STAT3 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260810%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair H4-16 H4C1 RNF8 H4C6 XRCC6 XRCC5 RAD51 MDC1 NBN TP53BP1 ATM NASP-1 SUPT16H RAD54L RNF168-1 NAP1L1 SSRP1 SETD2 PRKDC GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260810%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR MKS1 KIF3A RAB23 BBS4 CEP19 IFT172 CEP120 TXNDC15 CDK20 TRAPPC11 KIFAP3 CEP97 ARMC9 RPGRIP1L LZTFL1 IFT88 TTC30A;TTC30B WDPCP TEDC1 CEP104 TEDC2 ARL6 ARL3 FBF1 TTBK2 KIF3B TTC21B INPP5E CEP76 PIBF1 BBS2 BBS1 CPLANE1 FUZ CPLANE2 TMEM231 IFT20 TMEM17 SASS6 CEP83 CIBAR1 TTC26 TTC23 C2CD3 CBY1 EFCAB7 IFT52 TCTN3 TCTN2 DYNC2H1 TMEM107 DYNC2I2 TCTN1 DYNC2I1 BBS9 BBS7 IFT57 CC2D2A DYNLT1 BBS5 IFT140 MKKS DYNLT2B CEP295 WDR19 IFT122 BBS10 IFT80 EVC WDR35 BBS12 HSPB11 TMEM216 DYNC2LI1 CILK1 TULP3 KATNB1 TUBD1 IFT43 IFT74 IFT81 ARL13B IFT27 TMEM67 EVC2 SCLT1 IFT46 TUBE1 RABL2A;RABL2B MIB1 TTC8 CEP162 B9D1 CEP43 CLUAP1 CEP44 CEP192 KIAA0753 OFD1-1 CEP20 TRAF3IP1 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260810%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer RPH3AL SYTL1 GCC2 MYRIP SYTL5 MLPH SYTL4 UNC13D SYTL3 SYTL2 RPH3A MADD TBC1D10A EXPH5 RAB27A RAB27B MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260810%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy PRKCB HDAC4 HDAC5 MAP2K3 PIK3CD PIK3R3 PIK3R2 PIK3CB PIK3R1 MTOR NPPB MAP2K2;MAP2K1 PIK3CA NFATC4 HDAC9 HDAC7 ROCK2 MAPK1 MYLK3 AKT1 RAF1 TAB1 GATA4 MAP2K6 MAPK3 LIF PIK3CG TNF RAC1 ROCK1 AKT2 RHOA MAPK4 AGT PLCB2 MAPK14 GSK3B FGF2 PLA2G2A-1 DVL1 IKBKB PPP3CA MYEF2 NPPA EIF2B5 IKBKG IKBKE EDN1 FZD1 RCAN1 PRKG1 PPP3CB FZD2 MAP2K4 CHUK IL6ST PDPK1 NRG1 WNT3A CAMK2D MAPK8 MAPK7 MAP2K7 WNT5A MAP2K5 TGFB1 EGF IGF1 MYLK NFKB1 CDK9 CDK7 CTF1 CALM1 LRP5 MAP3K14 FGFR2 LRP6 CTNNB1 IGF1R STAT3 CISH PROLACTIN SIGNALING%WIKIPATHWAYS_20260810%WP2037%HOMO SAPIENS Prolactin signaling SOCS3 STAT5A STAT5B PIK3R2 PIK3CB PIK3R1 MTOR MAP2K2;MAP2K1 ITGB1 PIK3CA NEK3 NFKBIA CTSD PPIA EIF4EBP1 GRB2 MAPK1 AKT1 RAF1 YWHAG JAK2 SIRPA;SIRPB1;SIRPG RPS6KA2 HRAS MAPK3 SHC1-1 IRS1 PIK3CG RPS6 GAB2 YWHAZ TEC RPS6KB1 CASP3 FOS SOS1 IRS2 RAC1 ELK1 PTK2 NFKBIB ZAP70 SRC AGAP2 FYN RELA MAPK9 JUN PTPN11 MAPK14 GSK3B PXN PTPN6 PIAS3 PRL MAPK8 ERBB2 PTPN1 CBL PRLR NFKB1 PPIB SOCS1 SOCS2 JAK1 STAT1 PAK1 FLNA STAT3 CISH VAV1 MYC VAV2 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260810%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds TCF4 CSNK1A1 SFRP4 AXIN1 FZD8 APC GSK3B LEF1 DVL2 LRP1 FZD1 MBOAT1 DKK3 FZD7 WNT1 CTNNB1 TNKS HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260810%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HIF1A SLC2A1 GAPDH-1 GPAT3 CD36 LDHA PPARG TPI1 GPD1 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260810%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway C9 C3AR1 MASP2 COLEC11 FCN2;FCN1 C3-1 C5 C5AR1 ACE2 C8A C6 C7 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260810%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases FZD5 FZD4 HEY2 FZD8 PIK3CD PIK3R3 SMAD1 SMAD9 PIK3R2 SMAD5 PIK3CB PIK3R1 FGFR1 WNT8A PIK3CA DLL1 GLI2 DLL3 DLL4 MAPK1 MYOD1 BMPR1A PRKDC FGF3 MAPK3 GLI3 FGF6 SMAD4 FGF9 FGF18 JAG2 HEY1 FGF7 NOTCH2 WNT2B NOTCH1 FGF1 FGF4 FGF8 WNT1 WNT2 WNT3A WNT7B WNT5A JAG1 BMP4 FGF10 CTNNB1 FGFR4 FGFR3 PRKCG PRKCB PIK3R5 IHH FGF5 PIK3R6 WNT9A WNT8B HES3 HES2 PIK3CG PRKCD PRKCA MAPK6 MAPK4 SMO FZD10 PRKCI PRKCH MAPK9 WNT5B PRKCE MAPK14 PRKCQ MAPK12 MAPK13 MAPK10 PRKCZ MAPK11 FGF2 WNT6 WNT3 PIK3C2G WNT4 PIK3C2A FZD1 PIK3C2B WNT10B WNT10A FZD3 FZD2 FZD7 FZD6 FZD9 HES6 PRKD1 PIK3C3 MAPK8 MAPK7 PIK3R4 WNT9B WNT16 RBPJ PPARG LRP5 SOX9 FGFR2 LRP6 PTCH1 WNT11 WNT7A NOTCH3 BMP2 NOTCH4 BMPR2 STAT1 BMPR1B RUNX2 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260810%WP5028%HOMO SAPIENS Glycine metabolism including IMDs BOLA3 NFU1 PNPO ISCU GLDC AMT DLD SHMT1 LIPT2 LIPT1 GLRX5 GCSH-3 IBA57 HSCB LIAS EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP581%HOMO SAPIENS EPO receptor signaling PDK1 PTPRC STAT5A STAT5B EPO MAP2K2;MAP2K1 GRB2 MAPK1 AKT1 RAF1 JAK2 MAPK3 SHC1-1 IRS1 PIK3CG PTPRU SOS1 IRS2 SOCS1 SRC STAT1 STAT3 CISH RASA1 EPOR PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260810%WP5088%HOMO SAPIENS Prostaglandin signaling CCL3L1;CCL3L3;CCL3;CCL18 CD28 CSF1 IL17F PYCARD CCR2 CASP1 NLRP3 CXCL10 PTGER4 CXCL9 PTGER2 PTGES CXCL8 AREG PIK3CG TNF MMP9 TGFB1 KLRD1 VEGFA NFKB1 IFNG IL6 IL1B IL1A AHR IRF7 CCL13;CCL2 IL12A IL17A CXCL2;CXCL3;CXCL1-1 G13 SIGNALING%WIKIPATHWAYS_20260810%WP524%HOMO SAPIENS G13 signaling TNK2 PIK3CD MAPK10 PIK3R2 WAS PIK3CB IQGAP1 PIK3CA ROCK2 MAP3K4 PIP4K2A ARHGDIG PAK3 RPS6KB1 RTKN CYFIP1 IQGAP2 SH3RF1 ROCK1 RHPN2 RAC1 MYBPH CIT CALM1 PFN1 CFL2 PPP1CB ARHGDIB CFL1 RHOA LIMK1 MYL1 DIAPH1 GNA13 WASL CDC42 ARHGEF1 PKN1 NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260810%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2-2 PTGS1 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260810%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation PLG F2 F13A1 FGB FGA F13B FGG PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260810%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence PTGS2-2 RB1 PTGIS MAPK11 ALOX15 ALOX12 LTC4S CYSLTR1 ALOX15B PRXL2B KRAS CDKN1A ALOX5AP LTA4H PTGER4 PTGDS PTGER1 PTGER2 PTGES PTGER3 HRAS ALOX5 IGFBP5 ADCY3 GNAI1 NRAS SIRT1 GNAS-1 TP53 GNAQ TBXAS1 PTGS1 PLA2G4A INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260810%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment CCL5 TGFB2 IL2RG NFKB2 IL2RA IL2RB CXCL10 PIAS3 TGFB3 TGFB1 TGFBR2 NFKB1 IRAK4 PDCD1 CD86 TRAF6 CD80 SOCS1 CCL13;CCL2 CTLA4 STAT6 TLR8 TLR7 IL4R STAT3 TLR4 IL4 CD274 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260810%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway TLR7 TMPRSS2 ACAT1 FURIN ACE2 TMPRSS4 CTSV;CTSL NRP1 SCARB1 SLC6A19 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260810%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome ATM ATR RNF168-1 NIPBL RNF8 CBX3-1 MDC1 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260810%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence PTGS2-2 RB1 PTGIS MAPK11 PTGES2 ALOX15 ALOX12 LTC4S CYSLTR1 ALOX15B PRXL2B CDKN1A ALOX5AP DPEP1 HPGD LTA4H AKR1B1 GGT1 PTGDS DECR1 PTGR2 CBR1-1 PTGES ALDH1A1 FADS2 ALOX5 PTGES3-1 FADS1 GSTP1 ABCC4 ELOVL2 GPX1 SIRT1 HPGDS ALOXE3 SLCO2A1 SERPINE1 TP53 ELOVL5 EPHX2 TBXAS1 PTGS1 PLA2G4A GGT5 DPEP2 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260810%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer AKT1S1 PDK1 TSC2 TSC1 PIK3R1 MTOR PTEN MAP2K2;MAP2K1 BRAF PIK3CA TELO2 EIF4EBP1 GRB2 KRAS MAPK1 AKT1 RAF1 RPTOR HRAS MAPK3 IRS1 MAPKAP1 DEPTOR PARP1 RICTOR MLST8 RPS6KB1 AR SOS1 SOS2 AKT2 NRAS AKT3 PRR5L PARP2 INPP4B ARAF 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome MMP23B DLL1 ARF6 IFIH1 PEX12 SMAD4 TRIM25 TRAF2 SKI GRIK2 ISG15 HES5 CALML6 NADK PANK4 INTS11 DKK3 INTS13 INTS14 INTS10 GNB1 CDK11A;CDK11B GDE1 TMEM52 NOC2L OR4F21;OR4F16;OR4F29;OR4F3 METTL14 SDF4 CUL3 ELAVL1 PLEKHN1 CCNL2 TNFRSF4 SAMD11 MUSK IFIT1 TNFRSF18 OR4F5;OR4F17;OR4F4 TRAF5 SSU72 PEX2 COMMD1 ACAP3 RER1 PRKCZ SCNN1D CPTP DVL1 C1QTNF12 PEX5 MXRA8 VWA1 AURKAIP1 ESR1 PERM1 KLHL17 MEPCE DLST LRP4 UBE2J2 PARD6B ATAD3A;ATAD3B PHKG2 GABRD BTLA TNFRSF14 PUSL1 TAS1R3 HES4 MRPL20 TNFSF18 CFAP74 CD160 TGFB1 MIB2 B3GALT6 PEX10 VTN RNF223 VEGFA MORN1 TNFSF4 FNDC10 ANKRD65 SMAD2;SMAD3 INTS4 PLCH2 INTS9 SLC35E2B C1orf159 HSPA8 AGRN KRT17 RBX1 MCM2 NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260810%WP4220%HOMO SAPIENS Neurotransmitter disorders SLC6A3 DBH COMT TPH1 TH DDC PNMT SLC18A2 TPH2 MAOA TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260810%WP2113%HOMO SAPIENS Type III interferon signaling STAT2 JAK1 STAT1 IRF9 IL10RB IFNL2;IFNL3;IFNL1 IFNLR1 TYK2 PEPTIDE GPCRS%WIKIPATHWAYS_20260810%WP24%HOMO SAPIENS Peptide GPCRs MC5R GHSR MC4R CCR8 NMBR LHCGR NPY1R OPRL1 MC1R FSHR HCRTR2 HCRTR1 TACR1 SSTR1 SSTR2 GRPR EDNRA GNRHR CCR5 BDKRB2 BDKRB1 NPY5R AVPR2 TACR3 OPRM1 SSTR3 AGTR1 TSHR SSTR4 SSTR5 CCKBR AGTR2 CXCR5 CX3CR1 FPR2 C3AR1 OPRK1 OXTR C5AR1 CXCR3 EDNRB CCR3 NTSR1 CCR2 TRHR FPR1 CXCR1 MC2R GALR3 ACKR1 GALR2 GALR1 MC3R CCR10 NTSR2 CCR1 NPY4R2;NPY4R BRS3 CCKAR ATP8A1 NPY2R CCR9 CXCR4 CCR7 TACR2 CXCR2 CCR6 CXCR6 CCR4 TAC4 AVPR1B AVPR1A OPRD1 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260810%WP5133%HOMO SAPIENS Non classical role of vitamin D CYP27B1 ACE AGT CYP2R1 AGTR1 ACE2 REN AGTR2 LAC PHE PATHWAY%WIKIPATHWAYS_20260810%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260810%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260810%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization CCL4L2;CCL4L1;CCL4 IL12RB2 CCL3L1;CCL3L3;CCL3;CCL18 CD4 CD28 TGFB2 IL18R1 CXCR3 CCR3 IL5 CCR2 TGFB3 CCR1 TGFB1 IFNG CXCR4 CCR5 CCR7 CCR4 IL12B CSF2 IL12A IL4R IL2 IL4 CD40LG IFNGR1 IFNGR2 IL12RB1 ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260810%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias TIMP3 HDAC4 MMP13 STAT5B COL2A1 TGFB2 PTHLH CAB39 FGFR1 SCIN SOX6 AKT1 IHH BMPR1A PRKACA-1 ENPP1 THRA GLI3 PTH IGF2 PTH1R MMP9 KIF3A PLAT FGF18 SERPINH1 GHR PLAU IFT88 CDKN1C HMGCS1-1 SPP1 ALPL FGF2 CTSV;CTSL MEF2C RUNX3 SLC38A2 MGP TGFB1 IGF1 VEGFA CALM1 SOX9 SOX5 PTCH1 BMP6 ADAMTS4 ADAMTS5 ADAMTS1 COL10A1 STAT1 NKX3-2 BMP7 IGF1R DDR2 RUNX2 ACAN CHST11 FRZB FGFR3 ERYTHROPOIESIS%WIKIPATHWAYS_20260810%WP5607%HOMO SAPIENS Erythropoiesis HBA2;HBA1 PTPRC IL3RA IL3 EPO KITLG TF KIT CD34 TFRC GATA2 FAS FASLG HBG2;HBG1 HBZ HBD;HBB CD79A GDF11 GATA1 EPOR VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260810%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins VKORC1 VKORC1L1 F2 F7 UBIAD1 GGCX F9 AIFM2 PROC NQO1 F10 PROS1 HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260810%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness ZEB1 DICER1 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260810%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit CD80 BCL2 CD28 SPN CD247 CD27 IL2 CD3G CD3E CD86 CD3D INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260810%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 RBBP4 JARID2 MORC3 ELL BCLAF1 SETX STK38 SUZ12 AEBP2 TRIM35 MTF2 RBBP7 EED EZH1 THRAP3 EZH2 FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260810%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma HIF1A TGFB2 PDGFB CTSK DVL2 VHL SFPQ-1 PRCC ARNT CUL2 TGFA ELOC-1 CDKN1A EGLN3 CADM2 COL21A1 TGFB3 CREBBP TGFB1 BIRC7 ELOB FH VEGFA TFE3 RBX1 SLC2A1 DIAPH1 TFEB EGLN2 SETD2 EPAS1 EGLN1 EP300 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260810%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX PTGR1-1 LTB4R ALOX15 ALOX12 CYSLTR2 LTC4S CYSLTR1 ALOX15B DPEP1 HPGD LTA4H PTGR2 ACOX2 ACOX3 PPARA PPARD ACOX1 ALOX5 TRPA1 TRPV1 EHHADH-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ACAA1-1 LTB4R2 GGT5 FPR2 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260810%WP5602%HOMO SAPIENS Caffeine in neurons ADORA2A ADRA1B ADRA1A ADRA1D INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260810%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR HDAC4 HDAC5 HDAC2 HDAC3 HDAC1 NFATC3 NFATC1 HDAC8 PPP3CA SP1 NFATC4 HDAC9 NFKBIA HDAC7 PPP3R1 PPP3CB CCNT1 NELFA NELFE SUPT4H1-1 HEXIM1 SUPT5H CREBBP NFATC2 NFKB1 CDK9 NELFB PPP3CC RELA EP300 NELFCD CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260810%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer PTGS2-2 TGFB2 MAP2K2;MAP2K1 BRAF BCL2 KRAS CDKN1A MAPK1 AKT1 RAF1 MAPK3 APPL1 DCC MSH3 SMAD4 PMAIP1 DDB2 TGFBR2 GADD45B GADD45A CASP3 BIRC5 FOS GADD45G RAC1 AKT2 CYCS-1 AKT3 MSH6 BAD RHOA TP53 BAX NTN1 RAC3 RALA-1 EXOC2 MAPK9 JUN TCF7L1 MSH2 APC TCF7 GSK3B MAPK10 TGFBR1-1 CASP9 POLK RALB APC2 MLH1 BAK1 RALGDS TGFB3 CCND1 MAPK8 TGFB1 CSNK1A1 AXIN1 AXIN2 LEF1 SMAD2;SMAD3 TCF7L2 TBK1 CTNNB1 BBC3 ARAF BCL2L11 MYC REL WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260810%WP4150%HOMO SAPIENS Wnt signaling in kidney disease FZD5 WNT5B FZD4 WNT2B FZD8 MAPK10 WNT6 DVL1 DVL2 DVL3 WNT3 WNT4 FZD1 WNT10B WNT10A FZD3 FZD2 WNT1 FZD7 WNT2 FZD6 FZD9 WNT3A WNT7B MAPK8 INVS NPHP3 WNT5A WNT9B WNT16 LRP5 LRP6 WNT11 RHOA WNT7A CTNNB1 MAPK9 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260810%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis PC PDHA1 MDH1 SLC2A4 ENO2 ENO3 PFKL PKM MPC1 TPI1 MPC2 PKLR ALDOB PGAM1 PGAM2 DLD GAPDH-1 FBP1 LDHA;LDHC FBP2 SLC2A5 PFKP LDHAL6B PGK1 LDHB ALDOC ENO1 PCK1 ALDOA MDH2 HK3 GPI GOT1-1 GOT2-1 SLC2A1 GCK HK2 HK1 LDHA SLC2A2 PFKM DLAT G6PC1 NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260810%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 PRKCG PRKCB NFKB2 KRAS MAPK1 VDR CD40 HRAS CAMK2A MAPK3 CXCL8 TYK2 IFI27L2 PRKCD TNF IFI44L RSAD2 RXRB DEFB4A;DEFB4B CYP27B1 RXRA CYP24A1 NRAS PRKCA ISG15 STAT2 TLR8 CCL13;CCL2 PLCB3 PLCB4 TLR4 PLCB1 TLR2 PLCD1 PLCB2 IFNGR1 IFNGR2 PLCG2 PLCE1 PRKCH MAPK9 JUN PRKCE MAPK14 CAMP PRKCQ NOD2 MAPK12 MAPK13 PRKCZ MAPK11 IKBKB SP1 SP3 TNFRSF1A CAMK2D MAPK8 MAPK7 CAMK2B CAV1 CAMK2G IFNG NFKB1 ETS1 IL6 JAK1 MED1 IFNAR2 RELB STAT1 RXRG CD40LG LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260810%WP4299%HOMO SAPIENS Lamin A processing pathway ZMPSTE24 LMNA ICMT CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260810%WP4918%HOMO SAPIENS Cellular proteostasis PFDN4-1 VBP1 PFDN1 PFDN2 PFDN5 PFDN6 MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260810%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CDKN1B CREB1 RAD52 CCND3 CDK6 ATM TP53 CDKN1A CDC25A CCNE1 CCND1 MYC E2F1 ABL1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260810%WP2878%HOMO SAPIENS PPAR alpha pathway APOA2 NR1H3 RXRA APOA1 CDK4 CDK1 APOA5 PLTP SLC27A1 EHHADH-1 CYP7A1 SCP2 ACADM CPT2 KLK15 APOC3 PPARA ACAA1-1 CCND1 CYP8B1 MYC CPT1A FABP1 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260810%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR MRE11 BRCA1 SEM1 CHEK2 CHEK1 PLK1 NBN SMC1A CDC25C FOXM1 FANCD2 BRCC3 TRIM28 BARD1 PRKDC MDM2-2 PCNA E2F1 BCL6 ATRIP RPA2 PML RAD52 RAD50 DCLRE1A UIMC1 FEN1 RAD51 CEP164 POLB HERC2 TOPBP1 RPA1 CDK2 RMI1 CDK1 EXO1 TOP3A RAD17 HUS1 RAD1 EEF1E1 TP53 ATM MCPH1 RAD9A PPM1D ATR RECQL5 CDC45 ABRAXAS1 RBBP8 CLSPN POLN CLK2 TDP1 UPF1 MSH2 SMARCAL1 RNF8 BRCA2 SP1 MDC1 IKBKG TP53BP1 MLH1 UBE2D3-1 BRIP1 PARP1 USP1 RECQL FANCI WRN FANCA XRCC5 RFWD3-2 PALB2 SMARCC2 MCM2 XPA CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260810%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling NOTCH2 DNER NOTCH1 ADAM10 DLL1 DLL3 DLL4 CHUK MAML2 MAML1 MAML3 DLK1 JAG1 RBPJ LEF1 HES1 NOTCH3 NOTCH4 PSEN2 RRAS CNTN6 JAG2 DLK2 PSEN1 MFAP1 HEY1 MFAP2 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260810%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NEU2 NEU3 GM2A SCARB2 PSAP GLB1 NEU1 GLA GALC HEXB HEXA GBA NPC1-1 LIPA NEU4 NPC2 ARSA LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260810%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance HIF1A TP53 CDKN1A BCL2L1 WNT6 ABCB1 KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260810%WP4236%HOMO SAPIENS Krebs cycle disorders PDHX FH SUCLA2 SUCLG1 DHTKD1 MPC1 DLST GPT LDHA;LDHC SUCLG2 PCK2 LDHA LDHB CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260810%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL17 RPL19 RPL35A RPL23A RPL3L RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPS6KA6 RPS6KA2 RPS6KA1 RPL38 RPS6 RPS6KB1 RPS6KB2 UBA52 RPL4 RPLP1-2 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL8 RPL10A RPS27A RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 FAU RPL7A RPS17 RPS16 RPS19 RPL18A RPS18 RPL37A-1 RPL35 RPLP2 RPL36-1 RPS11 RPL39 RPS10 RPL15-1 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPS5 RPL22 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 RPL28 RPL10;RPL10L-1 RPL23 MRPL19 RPL11 RPS15A RPS6KA3 RPL14 RPS3 RPL13 RPS2 RPL12-1 RPL18 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260810%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system IGF2BP1 XPO1 XPO4 EIF5A;EIF5AL1 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260810%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum GTF2H1 POLE GTF2H3 BRCA1 POLD2 GTF2H4 ERCC3 MNAT1 RFC1 SLX4IP ERCC2 GPS1 XRCC1 UVSSA RAD18 CUL4B PCNA CUL4A DDB2 POLD3 H4-16 POLD4 H4C1 DDB1 RPA2 H4C6 RFC5 RFC3 RFC4 LIG1 RFC2 RPA1 RPA3 POLE4 HMGN1 POLE2 POLE3 H3-3A POLH XPC POLK PARP1 SLX4 POLD1 CDK7 CHD1L ERCC4 RBX1 CETN2 ERCC1 XPA RAD23A ERCC8 USP7 ERCC6 LIG3 XAB2 RAD23B GTF2H2C;GTF2H2C_2;GTF2H2 CCNH REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260810%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition ESPL1 CDC20 APC SMC1A SMC3 BUB1B CENPE RAD21 STAG1 PTTG1;PTTG2 BUB3 BUB1 MAD1L1 MAD2L1 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260810%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders TERF1-1 TERF2IP H4-16 H2AZ2;H2AZ1 H4C1 H2AJ H4C6 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC5 H2BC1 H2AC20 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ACD H2AC14 H2AB2;H2AB3;H2AB1 TINF2 TERF2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC21 POT1 TPP1 PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260810%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases AKT1S1 PRPS1 KHK PDK1 BECN1 SNAP23 PKM MYL2 STAT3 BUB3 PAK2 PGK1 H3-3A HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260810%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease MAPK14 TGFBR2 FBN2 FBN3 POSTN LTBP2 CCN2 TGFBR1-1 SMAD2;SMAD3 FBN1 SERPINE1 ANGPT2 MAPK1 AGTR1 FLNA RUNX2 SHC1-1 MAPK3 TGFBR3 SMAD4 NR2C2 MAPK8 ENG LTBP1 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260810%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance PRKCG PDGFD PRKCB PDGFC PIK3CD PIK3R3 RRAS2 PIK3R2 PIK3CB PIK3R1 MRAS MTOR MAP2K2;MAP2K1 BRAF PIK3CA BCL2 EIF4EBP1 GRB2 KRAS MET MAPK1 AKT1 GAB1 RAF1 AXL EIF4E JAK2 NF1 HRAS MAPK3 SHC1-1 PDGFRB GAS6 PDGFRA RPS6 RPS6KB1 RPS6KB2 KDR SOS1 NRG2 SOS2 AKT2 AKT3 NRAS PRKCA BAD BAX SRC FOXO3 PLCG2 PLCG1 EIF4E2 GSK3B PDGFB FGF2 PDGFA PTEN TGFA IL6R PDPK1 NRG1 EGFR CCND1 ERBB3 HGF ERBB2 EGF IGF1 VEGFA IL6 FGFR2 SHC4 SHC2 SHC3 JAK1 BCL2L1 IGF1R STAT3 ARAF BCL2L11 RRAS MYC FGFR3 TGF 1 SMAD2 3 SIGNALLING IN DECIDUAL NK CELLS AT THE FETAL MATERNAL INTERFACE%WIKIPATHWAYS_20260810%WP5637%HOMO SAPIENS TGF 1 SMAD2 3 signalling in decidual NK cells at the fetal maternal interface TGFB1 ITGAE TGFBR2 CD4 PGF FOXP3 IFNG SMURF2 TGFBR1-1 FCGR3A;FCGR3B SMAD2;SMAD3 CD9 KLRC4-KLRK1;KLRK1 CD14 ANGPT1 IL2RA ANGPT2 ITGA1 CXCL10 VEGFC CXCL8 SMAD4 NCAM1 SMAD7 MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260810%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids HIF1A CERS1 PLD1 NFKB1 TSC1 ASAH2 MTOR PIK3CA S1PR1 CERK S1PR3 AKT1 SPHK2 IGF1R TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260810%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway TAF2 TBP TAF13 H4C1 MED23 TAF8 MED27 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260810%WP4155%HOMO SAPIENS Endometrial cancer PIK3CD PIK3R3 PIK3R2 PIK3CB PIK3R1 MAP2K2;MAP2K1 BRAF FGFR1 PIK3CA GRB2 KRAS CDKN1A MAPK1 AKT1 RAF1 CTNNA1 HRAS MAPK3 DDB2 GADD45B GADD45A FOS SOS1 GADD45G SOS2 AKT2 AKT3 NRAS ELK1 BAD TP53 BAX CTNNA2 FOXO3 TCF7L1 APC ILK TCF7 GSK3B FGF2 FGF1 CASP9 POLK PTEN APC2 BAK1 CTNNA3 PDPK1 EGFR CCND1 ERBB2 AXIN1 EGF AXIN2 LEF1 FGFR2 TCF7L2 CTNNB1 ARAF CDH1 MYC FGFR3 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260810%WP4565%HOMO SAPIENS Neural crest cell migration in cancer EPHB2 MMP8 PIK3CD PIK3R5 PIK3R3 PIK3CB CDH11 PIK3CA EPHB4 AKT1 PIK3R6 PAK3 PAK2 PAK5 PAK4 PIK3CG PIK3R4 MMP9 ARF1 TRIO FOS BUB1B-PAK6;PAK6 RAC1 AKT2 AKT3 NTRK2 RHOA EPHB6 EPHB1 EPHB3 SORT1 KIDINS220 NGEF NGFR MMP2 PAK1 STAT3 F2RL2 BDNF TIAM1 JUN SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260810%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ADAM17 AVPR1B AGTR1 ACE2 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260810%WP4147%HOMO SAPIENS PTF1A related regulatory pathway NKX6-1 PDX1 NOTCH1 CTNNB1 RBPJL PTF1A RBPJ KAT2B PROX1 FGF10 HES1 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260810%WP4271%HOMO SAPIENS Vitamin B12 disorders MMACHC MMADHC CD320 MTR-1 MTRR CUBN AMN MMAA CBLIF MMAB TCN2 TCN1 MMUT N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5153%HOMO SAPIENS N glycan biosynthesis DPAGT1 ALG8 B4GALT1 ALG9 ALG6 TUSC3 MPI PMM2 SRD5A3 ALG2 ALG14 ALG3 DOLK MOGS ALG12 ALG1 ALG11 DPM1 GMPPB DPM2 DPM3 MGAT2 MPDU1 B4GALT2 B4GALT3 MGAT4A-1 MAN1A2 GMPPA MAN1A1 ST6GAL1 ST6GAL2 ALG5 DDOST DAD1 MAN1B1 FUT8 GANAB MAN2A2 MAN2A1 MGAT5 MAN1C1 MGAT3 MGAT1 MGAT5B-1 MGAT4C MGAT4D DOLPP1 MGAT4B RPN2 STT3A STT3B RPN1 ALG10;ALG10B GPI RFT1 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260810%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control CLPP COQ5 COQ3 PINK1 LONP1 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 MICOS13 PLEK OPA1 HSPD1 MFN1 MFN2 STAT2 DNM1L SLC25A46 AIFM1 C1QBP MCL1 ATAD3A;ATAD3B PYCR1 HSPA9 MIPEP UBXN1 CLPB TXN2 OPA3 GDAP1L1 SACS UFD1 PMPCB PMPCA UBXN6 AFG3L2 OXA1L PPA2 YME1L1 MICU1 HTRA2 SPG7 TRAK1 MFF TIMM50 PITRM1 MSTO1 MARCHF5-1 DNAJC19 TIMM8A TIMMDC1 VCP-1 TXNRD2 AGK PRKN USP9X TMEM126A-1 PYCR2 PYCR3 GFER OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260810%WP5093%HOMO SAPIENS Opioid receptor pathways NEU2 PRKCG PRKCE SQSTM1 RGS4 TUBB4A;TUBB;TUBB8B;TUBB8 HDAC1 RGS9 ARC OPRL1 NOS2 GATA4 E2F1 HMOX1 PIK3CG TNF RPLP2 MAP1LC3B2;MAP1LC3B-1 ADCY1 PGM1 ADCY8 RAC1 ALDH9A1 GNAI2 HSPA8 DNMT3A OPRM1 MBP GNA12 TLR4 CACNA1B BDNF RELA JUP GLYCINE METABOLISM%WIKIPATHWAYS_20260810%WP1495%HOMO SAPIENS Glycine metabolism MTHFR SHMT2 SHMT1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260810%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLC7A8 SLC16A10 SLCO1C1 SLCO3A1 SLC16A2 SLC7A5 SLCO4A1 SLCO1A2 MITOPHAGY%WIKIPATHWAYS_20260810%WP5636%HOMO SAPIENS Mitophagy EIF2AK3 SQSTM1 SMURF1 PINK1 ATF4 CITED2 TOMM20 RABGEF1 BCL2L13 FUNDC1 RAB7A ARIH1 USP30 ATG9B EIF2S1 MUL1 BECN2 KRAS TAX1BP1 FKBP8 PGAM5 RAB7B TOMM40 SAMM50 TBC1D17 CCZ1;CCZ1B TBC1D15 FIS1 HUWE1 TOMM7 E2F1 CALCOCO2 TRAF2 CSNK2A1;CSNK2A3 NLRX1 OPA1 TFE3 NBR1 MFN1 MFN2 TFEB SRC TOMM70 FOXO3 CSNK2A2 MAPK9 JUN HIF1A MAPK10 BNIP3L BNIP3 SP1 USP15 USP8 MTX1 MAPK8 AMFR BECN1 MAP1LC3A ATG9A AMBRA1 RHOT1 RAB5B MITF RAB5C TBK1 SIAH1 BCL2L1 MARCHF5-1 OPTN-1 VCP-1 ULK1 PRKN PHB2 RAB5A ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260810%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria COX6A1 UCP1 COX6B1 SLC25A5 SLC25A6 ATP5IF1 SCO1 SLC25A14 COX7B COX15 COX17 COX4I1 ATP5MC2 ATP5MC3 ATP5MC1 NDUFA11 SLC25A27 NDUFA12 SLC25A4 ATP5F1A NDUFA10 ATP5F1B COX6A2 COX11 SDHC ATP5MG SDHD ATP5ME DMAC2L COX8A SDHA ATP5PF SDHB SURF1 ATP5PD COX7A2 ATP5PB ATP5F1C NDUFC2;NDUFC2-KCTD14 ATP5F1D NDUFV3 ATP5PO NDUFV2 NDUFS5-1 NDUFC1 COX5B NDUFS7 NDUFS6 NDUFS4 NDUFS2 NDUFS1 NDUFB9 NDUFB8 COX6C NDUFB7 NDUFB6 COX7A2L-1 NDUFA13 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFAB1 COX7C UQCRFS1 NDUFS8 UQCRC1 NDUFS3 UQCRC2 UQCRB UQCR11 UQCR10 COX5A NDUFV1 NDUFB10 NDUFA9 UCP3 NDUFA4 UCP2 UQCRQ PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260810%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway TUBB3;TUBB6 SNCAIP TUBA3E;TUBA3C-1 STUB1 TUBB4A;TUBB;TUBB8B;TUBB8 TUBA8 FBXW7 TUBB2B;TUBB2A TUBAL3 CCNE1 CUL1 CASP8 UBE2L6 PSMD8 PSMD9 RNF19A PSMD6 CASK HSPA14 PSMD7 HSPA1L PSMD4 SIAH2 HSPA1A;HSPA1B PSMD2 HSPA6 PSMD3 SEPTIN5 PSMD1 UBE2G1 SNCA HSPA2 UBE2G2 PSMC2-1 CASP1 TUBA1C PSMD5 UBE2J2 PSMD10 HSPA9 PSMD11 UBE2J1 TUBB4B PSMC5 PSMC6 UBA1 PSMC3 PSMC4 PSMC1 TUBB1 HSPA8 TUBA4A SIAH1 TUBA1A GPR37 HSPA4 PSMD12 PSMD14 PSMD13 PRKN HSPA5 MELANOMA%WIKIPATHWAYS_20260810%WP4685%HOMO SAPIENS Melanoma RB1 PIK3CD PIK3R3 E2F3 PIK3R2 PIK3CB PIK3R1 MAP2K2;MAP2K1 BRAF PIK3CA GRB2 KRAS CDKN1A GRIN2A MAPK1 AKT1 RAF1 NF1 HRAS MDM2-2 MAPK3 E2F1 DDB2 GADD45B GADD45A GRM3 KDR SOS1 GADD45G RAC1 SOS2 CDK6 AKT2 AKT3 NRAS CDK4 BAD CALML6 RHOA CALML3 PDE5A TP53 CALML4 RHOC BAX RHOB STK19 PREX2 EXOC7 PTPN11 POLK PTEN E2F2 BAK1 CDKN2A CCND1 ERBB4 VCL CALM1 KIT SHC2 CALM3;CALM1 MITF CALM2 PAK1 ARAF CTTN CDH1 LUPUS THERAPIES%WIKIPATHWAYS_20260810%WP5560%HOMO SAPIENS Lupus therapies TNFSF13B CD22 IL25 CD28 C1QB IL17F IL17D IL17C C2 IL17B C1QC LOC110384692;C4A;C4B_2;C4B IL6R CD40 C3-1 IFNG IL6 MS4A1 CD86 CD80 CD38 IL12B IL12A IL23A IL17A CD40LG CD19 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260810%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling PTPN11 TSLP MAPK14 FES CRLF2 STAT5A STAT5B MAP2K2;MAP2K1 NFKB2 NFKBIA EIF4EBP1 MAPK1 AKT1 JAK2 MAPK3 MAPK8 LYN YES1 RPS6 GAB2 TEC NFKB1 STAT4 STAT6 JAK1 SRC RELB STAT1 HCK LCK STAT3 IL7R FYN RELA MAPK9 BTK VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2877%HOMO SAPIENS Vitamin D receptor pathway TIMP3 CDKN1B CYP2C9;CYP2C19 IRF8 VDR IRF4 CCNE1 NRIP1 PPARD ABCB1 PTH BCL6 TNFRSF11B IGFBP5 FOXO1-1 DEFB4A;DEFB4B FGF23 GADD45A EFNA5 TPM1 ADRA1B CDK2 LRRC8A CTLA4 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 RASGRP1 SULT2A1-4 HIF1A JUNB STEAP4 IL25 LPGAT1 GXYLT2 PRDM1 CLDN2 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 LGALS9C;LGALS9;LGALS9B STS SALL4 KRT16;KRT14 IGFBP3 KRT71 NOX1 SLC34A2 MED9 CDC34 EPHB4 NINJ1 S100A8 CEBPA COL13A1 CLEC16A CDKN2D TNFSF11 CCNC-1 KL CDKN2B CRACR2A CYP7A1 CDKN2C CRACR2B PTGER4 ATP2C2 DND1 CDKN2A SLC37A2 CYP2S1 CASP5;CASP4 PNOC CCND1 STAM CLPTM1L IGSF9B MXD1 ORM2;ORM1 SULT1C2 DUSP10 DACT2 CA9 ABCD1 SERPINB1 SATB1 SEMA3B CDKAL1 ASAP2 CBS;CBSL ALPG;ALPP;ALPI-1 IL1RL1 CLMN S100A6 CREG2 LRRC25 S100A9 S100G CDX2 TRPV6 KRT13 MYO9B DEFB132 BMP6 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 G0S2 IL12A KLF4 MYC ITGAM IGFBP1 TGFB2 SLC2A4 PTHLH CD14 TRPV5 CDKN1A COLEC11 HNF1A ADGRE5 CD40 G6PD ADRB2 TNFAIP3 TREM1 ALOX5 CYP27B1 RXRA CYP24A1 CD9 CASP14 SOSTDC1 KNG1 CYP2B6 BDKRB1 IRF5 SFRP1 S100A4 CYP1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 KLK6 TIMP2 DNER SPP1 PRKCQ KRTAP8-1 CAMP HSD17B2 CD200 ID4 BTLA CST6 SLC8A1 TGFB1 SPRR1A;SPRR1B ATP2B1 NFATC2 THBD CYP2D6;LOC107987479;LOC107987478-1 TNFSF4 LRP5 S100A2 TRAK1 ADAMTS5 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 ID1 TP53 NETWORK%WIKIPATHWAYS_20260810%WP1742%HOMO SAPIENS TP53 network TNFSF10 GADD45A TP73 SUMO1 BID BOK BCL2 ATM TP53 CDKN1A BAX OTX2 CDKN2A BBC3 MDM2-2 TP63 MYC ABL1 PMAIP1 MTHFR DEFICIENCY%WIKIPATHWAYS_20260810%WP4288%HOMO SAPIENS MTHFR deficiency PCYT1A HNMT ALDH7A1 DNMT3B CASP3 GRIN2D CYCS-1 EHMT2 CASP9 DNMT3A PEMT ASMT CHPT1 GRIN2A COMT MTHFR BHMT NDUFAF7 GRIN1 CHDH CHKA EHMT1 DNMT1 MARS1 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260810%WP3947%HOMO SAPIENS Serotonin and anxiety CAMK2B PRKCB PLCD4 TRPV1 GRM1 FOS PLEK FMR1 ARC ADRA1A PPP3CA HTR2A CRH EEF2K POMC GABRA1 HTR1A EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260810%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer FZD5 FZD4 MAP2K3 FZD8 PIK3CD PIK3R3 MMP15 PIK3R2 PIK3CB PIK3R1 SNAI2 WNT8A MAP2K2;MAP2K1 PIK3CA DLL1 DLL3 DLL4 KRAS FOXM1 MAPK1 AKT1 FMNL2 RAF1 ZEB2 MAP2K6 MAPK3 SHC1-1 SMAD4 NR2C2 RBBP4 COL4A6 AKT2 AKT3 TUSC3 CLDN11 LATS2 JAG2 HIF1A NOTCH2 FOXC2 WNT2B NOTCH1 CLDN2 DSP WNT1 WNT2 COL4A4 COL4A3 TGFB3 COL4A5 WNT3A WNT7B WNT5A VTN JAG1 CLDN6 OCLN-1 FN1 TJP1 SPARC PDCD6 CTNNB1 CDKL2 COL4A2 MMP2 CLDN3 PAK1 COL4A1 CLDN9 CLDN8 GDF15 CLDN7 PKP1 EIF5A2 CLDN23-1 NRP2 PKD1 CLDN20 CLDN22;CLDN24-1 CLDN10 CLDN15 CLDN14 CLDN12 CLDN19 TGFB2 STRAP CLDN18 CLDN17 CLDN16 NUBPL CRB3 GRB2 ITGA5 WNT9A WNT8B HRAS MMP9 TGFBR2 SOS1 SOS2 FOXQ1 TMPRSS4 SUZ12 EED TRAF6 TP53 MEF2D FZD10 MPP5 WNT5B MAPK14 CLDN4 MAPK12 MAPK13 GSK3B TGFBR1-1 MAPK11 WNT6 WNT3 WNT4 FZD1 PKP2 WNT10B WNT10A ID2-1 FZD3 EZH2 FZD2 MAP2K4 FZD7 ZEB1 FZD6 FZD9 PROX1 MAPK8 TGFB1 WNT9B DLK1 WNT16 RBPJ SMAD2;SMAD3 LRP5 LRP6 WNT11 WNT7A NOTCH3 TWIST2 NOTCH4 CLDN1 CTDSP1 CDH2 CDH1 ID1 SNAI1 CLDN5 JUP AMINO ACID METABOLISM%WIKIPATHWAYS_20260810%WP3925%HOMO SAPIENS Amino acid metabolism HMGCL CTH PDHX ASNS GCLM ADH1C;ADH1B;ADH1A TAT PDHA1 MDH1 FAH WARS1 GLUD1;GLUD2 CAD CS PKM HIBADH GLUL AUH HIBCH ARG2 LARS2 DLD GLS PPM1L HDC HADH IARS1 ACADM VARS1 MPST AOC3 G6PC2 EPRS1 OGDH ALDH1A1 ACO2 FARSB FH ADH5 MDH2 ADH4 DDC SDHA ODC1 SRM BHMT SMS MMUT P4HA2 ALDH7A1 PC ALDH18A1 MCCC1 SUCLG1 PNMT SDS MAOA RARS1 TPO DBH ACSS1 DLST OAT ARG1 TH PYCR1 ACLY ASS1 CPS1 GSR PDK4 HNMT PCK1 OTC IDH1 TPH1 CBS;CBSL HAL GPT2 FTCD GOT1-1 GOT2-1 EHHADH-1 TDO2 BCAT1 MARS2 LDHA ACAA1-1 GSS HMGCS2 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260810%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma RB1 SESN2 PRKAA1 PIK3R5 TSC2 TSC1 PIK3R2 PIK3CB SESN1 FADD PIK3R1 MTOR FGFR1 PIK3CA NFKB2 NFE2L2 EIF4EBP1 KRAS CDKN1A AKT1 RPTOR EIF4E RHEB HRAS MAPKAP1 SMAD4 STK11 E2F1 PIK3CG RPS6 RICTOR CSMD3 CASP8 LTBR MLST8 FKBP1A RPS6KB2 TGFBR2 CDK6 AKT2 AKT3 TRAF3 NRAS PRKAA2 CDK4 TP53 CUL3 RELA KEAP1 NOTCH2 NOTCH1 PTEN PDPK1 CDKN2A MAML1 TERT EGFR CCND1 TP63 IRF6 NUMB ERBB2 VEGFA NFKB1 FAT1 AJUBA CTNNB1 IGF1R DDIT4 FGFR3 REL BIRC2 PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260810%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins AKT1S1 SQSTM1 VPS18 VPS33A APOB ATG4A MTOR PKM ATG2B RAB7A VPS11 VPS16 TMEM59 TAX1BP1 AKT1 RPTOR RHEB DEPTOR EIF4B RPS6 RB1CC1 PPP1R9A LAMP2 MLST8 RPS6KB1 LARP1-1 CALCOCO2 MAP1LC3B2;MAP1LC3B-1 VAMP8 ATG3 LAMTOR1 ATG12-1 VPS39 ATG9A VPS41 ATG13 NBR1 ATG5 GABARAPL2 PRKAA2 ATG7 ATG16L1 OPTN-1 ULK1 COMPLEMENT SYSTEM%WIKIPATHWAYS_20260810%WP2806%HOMO SAPIENS Complement system ICAM2 CFD C5 C1S ITGA2 CFB CFP C8A C2 C6 C7 C9 MASP2 PRNP ARRB2 MASP1 GNA15 CD55 FCN2;FCN1 PRKACA-1 CD40 ITGB3 CLEC4M;CD209-2 ICAM1 IBSP C4BPA VSIG4 C3-1 CD93 CRP CFHR1;CFHR2 FGB FCER2 ADM FGA APCS FCGR3A;FCGR3B FKBP2 GNAI3 LAMB1 LRP2 F10 PRKCA MBL2-1 GNAI2 CD59 F11 SELL FGG ALB TXN PLG F12 SERPING1 SELPLG TLR2 KLKB1 SELP PROS1 CD19 C1QBP C3AR1 CR2 C5AR2 SPP1 SELE APOA1 CFI C5AR1 WAS CFH-3 CPN1 PLAUR FPR1 LOC110384692;C4A;C4B_2;C4B RPS19 PTX3 CSNK1A1 LAMA5 F13A1 VTN CR1L;CR1 ITGA2B DCN ELANE LAMC1 THBS1 ADIPOQ CALR-1 TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260810%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners SKI MERTK HDAC3 SATB2 HDAC1 SIN3A TEAD1 TEAD2 STK3 TEAD3 TEAD4 ING2 LATS1 PRMT5 LATS2 NF1 SKIL MECP2 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260810%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells TALDO1 PGLS TP53 DERA RPIA G6PD RPE;RPEL1 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260810%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism EPHX2 ALOX15 ALOX5 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome NEIL2 NKX6-1 PPP1R3B XKR6 SLC2A4 CTSD MAPK1 RAF1 FDFT1 NUMA1 GATA4 SGPL1 TERT CTSB MAPK3 MTMR8 TBX5 TERF1-1 MTMR9 AXIN1 CGAS MTMR6 PDX1 MTMR7 MEPE SLC35G4;SLC35G5;SLC35G3;SLC35G6 HSPD1 MSRA SLBP CSTA PINX1 HEPACAM2 CTNNB1 ERI1 SOX7 TLR4 S100A10 MCRS1 TLR2 TNKS DEFB135 C8orf74 RP1L1 BMP1 CLDN23-1 MFHAS1 BLK FAM167A LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260810%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions LPL ITGAL NDRG1 MAPK14 FOXO6 STK38L FYB1 KNSTRN-1 RAB13 PRDM1 FERMT3 MST1 YWHAQ FOXO1-1 FOXP3 RAC1 YAP1-1 RASSF5 TEAD1 TEAD2 STK3 TEAD3 SAV1 CCR7 TEAD4 RHOA MOB1A;MOB1B FOXO4 RAP1A WWTR1 LATS1 LATS2 FOXO3 CD19 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260810%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260810%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid ACSS2 GLYAT IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260810%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity MMP9 ICAM1 F2R F2 HBEGF NFKB1 IFNG IRAK1 TIMP1 PLA2G7 TLR1 SELENBP1 FCER1A IL1B S100A9 CCR3 PIK3CA IL1R1 NLRP3 CCL13;CCL2 MYD88 IL18 TLR2 TIMP2 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260810%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer HDAC4 HDAC7 HDAC5 DNAJB1 CREB1 SIK1;SIK1B CRTC2 PRKACA-1 SIK3 SIK2 GNAS-1 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260810%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase COX5A GSTP1 CYP2C9;CYP2C19 EPHX2 COX8A CYP2J2-1 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260810%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation PTGS2-2 PTGFR ANXA5 PPARGC1A PTGIS EDNRB PTGDR ANXA1 ANXA6 PTGFRN EDN1 ANXA3 ANXA4 SCGB1A1 HPGD AKR1B1 PRL PTGER4 PTGDS PTGER1 CBR1-1 ANXA8;ANXA8L1 PTGER2 PTGES PTGER3 ABCC4 EDNRA PPARG SOX9 S100A6 HPGDS MITF PTGIR TBXA2R PPARGC1B TBXAS1 S100A10 PTGS1 HSD11B1 PLA2G4A HSD11B2 CYP11A1 ANXA2 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260810%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells SLC2A1 PDK1 SLC16A1 PDP1 PFKP HK1 LDHA PKM LUPUS PATHOGENESIS%WIKIPATHWAYS_20260810%WP5559%HOMO SAPIENS Lupus pathogenesis BCR ICOS TNFSF13B CD28 IL6 PDCD1 CD86 CD80 TLR9 TLR7 LOC102723996;ICOSLG TNFRSF13C IL17A TLR4 CD40 CD40LG CD274 DRAVET SYNDROME%WIKIPATHWAYS_20260810%WP5200%HOMO SAPIENS Dravet syndrome MAPK11 MTOR PIK3CA CHD2 AKT1 PRR5 STXBP1 KCNA2 PCDH19 SNTA1 CAMK2A SCN3A SCN1B MAPKAP1 SCN2B RICTOR TNF MLST8 NFKB1 SCN8A SCN4B CALM1 HCN1 PRKCA PRR5L SCN1A SCN3B FGF13 SCN2A WNT SIGNALING NETPATH%WIKIPATHWAYS_20260810%WP363%HOMO SAPIENS Wnt signaling NetPath PRKCG TCF4 GSK3A PRKCB CSNK1D APC TSC2 GSK3B TSC1 DVL1 DVL2 MTOR DVL3 MAP3K7 ARRB2 PI4K2A MAPK1 AKT1 SOX1 CCND1 MAPK8 TPTEP2-CSNK1E;CSNK1E GCKR RYK-1 CSNK1G1 CSNK1A1 AXIN1 ROR1 NFATC2 PIP5K1B RAC1 ROR2 LEF1 CDK6 LRP5 PPARG CTBP1 PRKCA LRP6 NLK TCF7L2 RHOA BCL9 CTNNB1 MAPK9 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260810%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes HCN4 HDAC4 HAND2 KCNE1;KCNE1B HCN2 KCNJ2 GJA1 KCNQ1 IGF1 ERG PTBP2 SRF LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2874%HOMO SAPIENS Liver X receptor pathway FASN CYP2B6 SCD RXRA NR1H3 SREBF1 CYP7A1 ABCG8 ABCG5 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260810%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta LOX COL1A1 PLOD2 SP7 FZD1 TNFSF11 WNT1 TNFRSF11A MBTPS1 TNFRSF11B FKBP10 SERPINF1 MIA3 MBTPS2 TMEM38B COLGALT1 IFITM5 CRTAP LRP5 P3H2 P3H1 PPIB LRP6 PLOD1 ADAMTS2 COL1A2 SERPINH1 P4HB ITPR1 CREB3L1 BMP1 P4HA1 P4HA2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260810%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis TNF MAPK14 CASP3 MAPK12 MAPK13 MCL1 MAPK11 FADD CASP9 CASP7 BID BAD BCL2 BAX FASLG AKT1 BCL2L1 BBC3 BCL2L11 APAF1 CASP8 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260810%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome CR2 TRAF1 IFITM3;IFITM2;IFITM1 RAB4A LAT RABGEF1 PRMT1 GRB2 CD81 ATP2A1 JAK2 TRAF2 NFATC2 KDR C3-1 MPL CD82 NFATC2IP SH2B1 TUFM ATXN2L RABEP2 SPNS1 INSR VAV2 IL4 CD19 RAB5A HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260810%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease LMNB1 H2AZ2;H2AZ1 LMNA ACTA1 DES LBR NOTCH3 CBX5 DMPK MYOD1 HP1BP3 HSPB2 HSPB3 MYOG MEF2C FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260810%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling CCR6 STAT3 FLT3 CCR5 MAPK SIGNALING%WIKIPATHWAYS_20260810%WP382%HOMO SAPIENS MAPK signaling TAOK3 TAOK2 CACNA1E MAP2K3 CACNA1H CACNA1G CACNA1I MAP3K20 DUSP16 PPM1A PPM1B PTPN7 MAP2K2;MAP2K1 MKNK1 MKNK2 KRAS MAPK1 AKT1 RAF1 MAP3K11 MAP2K6 NF1 MAP3K5 FGF3 MAPK3 PDGFRB FGF6 DAXX FGF9 DUSP3 NGF GADD45A FGF23 SMIM40 PTPN5 AKT2 AKT3 FGF20 FGF22 FGF17 ELK1 CACNG8 PPP3CC FGF16 NTRK2 RAP1B FGF14 CACNG2 RAP1A FGF18 HSPA1A;HSPA1B FGF13 FGF12 FGF11 CDC25B RASGRP1 MAP3K4 PTPRR IL1R2 RELB ARAF CACNA1D CACNA1B CACNA1A FGFR4 MYC CACNA1C FGFR3 CACNA1F PRKCG ATF2 ATF4 CACNA1S TGFB2 NFATC3 NFATC1 BRAF GRB2 ARRB1 ARRB2 FASLG FGF5 HRAS PAK2 NTRK1 TNF TGFBR2 CASP3 SOS1 RAC1 SOS2 NRAS PRKCA IL1A TP53 FAS RASGRF1 RAC3 MAPKAPK5 JUN MAPK14 CRK JUND TGFBR1-1 CACNA2D1 CACNA2D3 FGF2 CACNA2D2 CACNA2D4 IKBKB PPP3CA CACNB1 CACNB2 IKBKG CACNB3 CACNB4 MAP3K7 PPP3R1 PPP3CB MAP4K1 CACNG6 MAP2K4 CACNG7 CHUK FGF21 CACNG1 CACNG3 TNFRSF1A CACNG4 CACNG5 MAPK8 MAPK7 MAP2K7 LRRK2 MAP2K5 TGFB1 MAP3K1 EGF NFKB1 MAP3K14 FGFR2 NLK RASGRP2 RASGRP4 PPP5C CRKL RASGRP3 RPS6KA3 RRAS FGF19 RASGRF2 PLA2G4F PLA2G4D PLA2G4E RRAS2 NR4A1 MRAS FGFR1 HSPB1 DUSP4 DUSP1 DUSP6 MAP3K6 MAP3K13 DUSP2 STMN1 MAP4K2 MAP4K3 TAOK1 MAP4K4 HSPA1L MAPT HSPA6 HSPA2 FGF7 PDGFB PDGFA FGF1 FGF4 NTF4 FGF8 EGFR TGFB3 DUSP10 FGF10 HSPA8 IL1R1 MAPKAPK3 MAP3K8 CDC42 PAK1 PLA2G4A RASA1 DDIT3 CD14 NFKB2 MAX TAB2 TAB1 RPS6KA4 PRKACA-1 RPS6KA5 PRKACB-1 PRKCD MAP3K2 TRAF2 LAMTOR3 ECSIT FOS IL1B STK4 STK3 TRAF6 GNA12 RELA MAP3K12 MAPK9 MAPK12 MAPK13 MAPK10 MAPK11 JMJD7-PLA2G4B;PLA2G4B MEF2C RASA2 SRF ELK4 MAPKAPK2 MAPK8IP2 FLNA MAPK8IP3 FLNB MAPK8IP1 FLNC DUSP8 DUSP9 BDNF DUSP7 RAPGEF2 NTF3 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome TUBGCP3 TUBGCP4 TUBGCP2 NIPA1 CYFIP1 NIPA2 FMR1 TUBGCP5 TUBGCP6 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260810%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators CCL14 CCL8 CXCL17 CXCL14 CCL1 IL36A IL36B IL36RN XCL1;XCL2 IL36G CCL16 OSM PPBP IL1F10 IL9 IL20 IL26 IL24 IL27 CCL17 CCL25 IL13 CCL24 IL31 CCL22 IL37 CCL27 CCL26 IL23A IL17A LTA PF4;PF4V1-1 CCL19 TNFSF13B TSLP CNTF IL25 CCL20 CSF1 CCL28 EPO IL17F IL17D IL17C IL17B CXCL12 IL11 IL18 VEGFA IFNG IL3 IL6 IL15 CTF1 IL12B CSF2 IL12A MMP3 CXCL2;CXCL3;CXCL1-1 IL2 EBI3 CCL3L1;CCL3L3;CCL3;CCL18 IL33 IL5 CXCL10 CXCL11 CXCL9 LIF CXCL8 TNF MMP9 IFNK IL10 CX3CL1 CCL23;CCL15 IL1B IL1A CCL13;CCL2 IL21 IL22 CXCL13 CCL21 CCL4L2;CCL4L1;CCL4 CCL5 SPP1 IFNB1-4 IL1RN AREG TGFB1 NFKB1 IL7 CCL11 IFNL2;IFNL3;IFNL1 CSF3 MMP1 IL19 IL4 CXCL5;CXCL6 COCAINE METABOLISM%WIKIPATHWAYS_20260810%WP2826%HOMO SAPIENS Cocaine metabolism BCHE CES2 CES1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 DNA REPLICATION%WIKIPATHWAYS_20260810%WP466%HOMO SAPIENS DNA replication GMNN POLE POLD2 MCM4 UBA52 RFC1 UBB;UBC CDC6 PRIM2 PCNA PRIM1 MCM7 POLD3 MCM10 POLD4 ORC5 ORC4 RPA2 ORC6 POLD1 ORC1 ORC3 ORC2 RFC5 CDT1 RFC3 RFC4 CDC7 DBF4 RFC2 MCM3 RPA1 CDK2 MCM5 MCM6 RPA3 POLA1 POLA2 MCM2 CDC45 POLE2 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260810%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway PLCG1 PLCD3 PLCD4 PIK3CD PIP5K1A PIK3CB IPMK FIG4 PTEN INPP5E PIK3C2G PIK3CA PIK3C2A PIK3C2B PIP4P2 PI4KA PIP4P1 PI4K2A PIP4K2A PIP4K2B PIP4K2C SACM1L OCRL INPP4A MTMR1 MTMR2 PIK3CG MTMR8 MTMR6 MTM1 PIP5K1B PIP5K1C PIKFYVE PI4K2B TPTE;TPTE2 INPP4B PI4KB PLCB3 PLCB4 PLCB1 PLCD1 INPP5D PLCB2 INPP5K PLCG2 PLCE1 TAR SYNDROME%WIKIPATHWAYS_20260810%WP5362%HOMO SAPIENS TAR syndrome RBCK1 ZFHX3 HDAC2 BCL2L13 ITGB1 MET MTA1 FARP2 LAMTOR1 SIRT1 CD3D POLR3GL TXN ANKRD35 EIF4A3 SLC22A12 SLK HJV LCK SUMO2 POLR3C PDZK1 SLC22A4 GPR89A;GPR89B PEX11B POLR3F CCAR2 CLCN3 POLR3G SLC9A3R1 MAGOH;MAGOHB UBE2I PEX19 BRF1 PYM1 PDZK1IP1 MITD1 FURIN CD247 AKAP10 PIAS3 DNM1 EGFR TNFRSF14 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD160 IFNG NFKB1 CFTR CXCR4 HAMP STAT3 DDIT4 ITGA10 FLT3 SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260810%WP4814%HOMO SAPIENS Somatic sex determination NR5A1 AMH DMRT1 DHH FOXL2 SRY RSPO1 ZFPM2 SOX9 WT1 WNT4 SOX8 CTNNB1 PTGDS GATA4 FGF9 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260810%WP5087%HOMO SAPIENS Pleural mesothelioma MAP2K3 PRKAA1 PIK3CD BRCA1 TSC2 CCND3 TSC1 CCND2 PIK3CB MTOR MAP2K2;MAP2K1 PIK3CA TELO2 MKNK1 MKNK2 EIF4EBP1 MAPK1 AKT1 RAF1 MAP3K11 CCNE1 MAP2K6 MAP3K5 MDM2-2 MAPK3 DEPTOR E2F1 RBBP4 TTI1 LAMA2 LAMA1 LAMA3 LAMC2 YAP1-1 LAMB3 AKT2 LAMB1 AKT3 TEAD1 CDK4 TEAD2 CDK2 TEAD3 TEAD4 PTK2 ATM MOB1A;MOB1B LATS1 PLCB4 FRAT2 LATS2 CSNK2A2 DKK2 DKK4 SFRP4 CSNK2B ULK2 HCFC1 PHC1 SETD5 PRSS23 NOTUM TNIK DSC3 TGFA PIGF KMT2C PORCN BAG2 BAK1 MDK WDR5 CXXC4 ASXL1 RASSF2 RASSF3 RASSF4 RASSF6 CER1 BTC SFRP5 CDH18 SETDB1 RASSF7 CSNK1A1 LIMD1 BMI1 KREMEN1 KIF23 IL34 WWC1 CHD8 SENP2 RNF2 SFRP2 LAMB2 LAMA4 HMGB1-1 ITGA1 FN1 LAMC1 CSF2 COL4A2 MMP2 MMP3 IDO1 CXCL2;CXCL3;CXCL1-1 COL4A1 ITPR3 CD274 ATF2 CD47 MCU FGF5 RHEB ITGB4 CDH5 KDR CCN2 IL10 SLC3A2 TP53 CCL13;CCL2 SRC FZD10 PLAU JUN WNT5B MAPK14 SELE MMP14 CTBP2 TCF7 GSK3B FGF2 WNT6 DVL1 DVL2 DVL3 ANGPT1 WNT3 WNT4 FZD1 ANGPT2 WNT10B WNT10A FZD3 FZD2 MAP4K1 FZD7 MAP2K4 FZD6 FZD9 BAP1 FOSL1 TPTEP2-CSNK1E;CSNK1E MAPK8 MAPK7 MAP2K7 MAP2K5 TGFB1 MAP3K1 AXIN1 EGF IGF1 NFKB1 WNT16 CD44 CDK7 RASSF1 LEF1 LRP5 RASSF5 FGFR2 LRP6 WNT11 TCF7L2 WNT7A JAK1 STAT1 CSF3 IGF1R RPS6KA3 CDH2 ACTA2 CDH1 CXCL5;CXCL6 NDRG1 PPARGC1A FGFR1 ITGB1 FLT1 MST1 SOX17 CUL1 SHC1-1 BTRC FOXO1-1 ROR1 CREB1 MAP3K9 WWTR1 SETD2 HIF1A FGF7 CSF1R HBEGF WNT2B KDM6A CSF1 MCL1 PDGFB PDGFA FGF1 FGF4 INS;INS-IGF2 NTF4 ITGA3 FGF8 WNT1 WNT2 TERT COL4A4 COL4A3 COL4A5 WNT3A WNT7B HGF WNT5A FLT3LG LAMA5 DKK1 VEGFA IL6 KITLG KIT FGF10 PAK1 CXCL10 MAX BARD1 PIK3CG IGF2 MLST8 MAP3K2 MAP3K3 CIT SUZ12 IL1B STK3 EED SAV1 MAP3K10 MAPK9 CCL4L2;CCL4L1;CCL4 CCL5 MAPK10 RING1 AGER SLC2A1 ADAMTS1 ULK1 BDNF PDGFD PDGFC SLC7A5 VEGFB VEGFC FOXM1 VEGFD FGF3 PDGFRB FGF6 PDGFRA FGF9 ITGB3 NGF ITGAV PGF FGF23 COL4A6 EFNA5 EFNA4 PRKAA2 FGF20 FGF22 FGF17 ELK1 EFNA1 NTRK2 EFNA3 FGF14 EFNA2 FGF18 FGF13 FGF12 FGF11 LAMC3 GABPA ANGPT4 CASP1 NLRP3 CXCL12 MAP3K4 RB1CC1 PRKAG1 SOST PRKAG2 SERPINF1 PRKAG3 BECN1 ATG13 BUB1B-PAK6;PAK6 CDH9 AMOT CDH7 PRKAB2 PRKAB1 CDH4 CDH3 CTHRC1 AJUBA EPHA2 CDH20 CDH22 CTNNB1 CDH24 NGFR INSR LIN28B FGFR4 MYC FGFR3 FLT3 FLT4 ITGB2 ITGA4 ITGA2 CDH10 CDH11 CDH12 CDH13 ITGA6 BCL2 CDH15 GRB2 CDKN1A CDH16 MET YWHAB CDH17 VGLL4 CDH19 CTNNA1 PAK3 MAD1L1 HRAS PAK2 PAK5 MAD2L1 PAK4 NTRK1 MMP9 TEK SOS1 CYCS-1 BAX MEF2D HMGN1 AKT1S1 PDK1 EZH2 CTNNA3 FGF21 CDH8 CDH6 ROR2 CTBP1 PODXL OGT-1 FGF19 FZD5 FZD8 NF2 MAP3K6 ACTC1;ACTG2 ACTG1 MAP4K2 MINK1 ACTA1 TNNT1 MAP4K3 MAP4K4 CTNNA2 TCF7L1 LGALS9C;LGALS9;LGALS9B SP1 CDKN2A EGFR UHRF1 YY1 CCND1 MDM4 ACTB-1 EIF4G1 SPARC BBC3 FABP4 DDIT3 ATF3 RPTOR RPS6KA5 RPS6KA1 EIF4B RPS6 RPS6KB1 RPS6KB2 TRAF2 CSNK2A1;CSNK2A3 SFRP1 WIF1 STK38L APC PTEN AREG RYK-1 MAPKAPK2 NTF3 TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260810%WP5496%HOMO SAPIENS Targeted therapy in breast cancer PIK3CD PIK3R5 PIK3R3 PIK3R2 PIK3CB PIK3R1 PIK3C2G PIK3CA PIK3C2A PIK3C2B KRAS MAPK1 AKT1 RAF1 PIK3R6 EGFR HRAS MAPK3 ERBB3 ERBB4 PIK3CG ERBB2 PIK3R4 AKT2 NRAS AKT3 NRF2 ARE REGULATION%WIKIPATHWAYS_20260810%WP4357%HOMO SAPIENS NRF2 ARE regulation EPHB2 SLC7A11 GCLM GSK3B AIMP2 NQO1 PRKCA GCLC PIK3CA NFE2L2 RBX1 CEBPB SRC PGAM5 GSTA3;GSTA5;GSTA1;GSTA2 INSR MAF MAPK8 YES1 CUL3 HMOX1 FYN KEAP1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260810%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling CDKN1B TCF7 GSK3B PDGFA CASP9 MTOR MAP2K2;MAP2K1 PIK3CA IKBKG NFKBIA BCL2 GRB2 KRAS CDKN1A MAPK1 RAF1 MDM2-2 CCND1 PDGFRB CREBBP FOXO1-1 AR NFKB1 SOS1 KLK3;KLK2 AKT3 BAD TP53 CTNNB1 CREB3L1 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260810%WP3287%HOMO SAPIENS Overview of nanoparticle effects TNF PTGS2-2 PIK3CD CRP LAMA3 CCND3 IL6 ITGAD AKT3 NFRKB CDH3 BCL2 FN1 PTK2 BAX COL4A1 PTGS1 CXCL8 HMOX1 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260810%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 ONE CARBON METABOLISM%WIKIPATHWAYS_20260810%WP241%HOMO SAPIENS One carbon metabolism DNMT3B AHCY MTR-1 TYMS MTHFR ST20-MTHFS;MTHFS MAT1A DHFR2;DHFR ATIC GART MAT2B AHCYL2 ALDH1L1 FTCD MTFMT GLRX DNMT3A FOLH1B;FOLH1 AMT MTHFD1 MTRR BHMT MTHFD2 CHDH SHMT2 SHMT1 MTHFD1L DNMT1 TCN2 CILIOPATHIES%WIKIPATHWAYS_20260810%WP4803%HOMO SAPIENS Ciliopathies XPNPEP3 AHI1 GLI2 MKS1 CRX GLI3 INVS NPHP3 ADCY6 CEP164 RAB23 BBS4 CEP19 IFT172 CEP120 ZIC2 RPGRIP1L LZTFL1 WDPCP CEP104 ARL6 ARL3 TTBK2 TTC21B INPP5E PIBF1 BBS2 BBS1 CPLANE1 TMEM231 TMEM17 CEP83 C2CD3 IFT52 TCTN3 TCTN2 DYNC2H1 TMEM107 DYNC2I2 TCTN1 DYNC2I1 BBS9 BBS7 IFT57 CC2D2A BBS5 IFT140 MKKS DYNLT2B WDR19 IFT122 BBS10 IFT80 EVC WDR35 BBS12 TMEM216 ODAD1 DYNC2LI1 CILK1 GALNT11 ODAD3 ODAD2 ODAD4 IFT43 MCIDAS IFT81 BBIP1 ARL13B TBC1D32 IFT27 TMEM67 CSPP1 EVC2 NEK1 SCLT1 NEK2 DNAAF3 DNAAF2 DNAAF1 TTC8 DNAJB13 DNAAF6 B9D1 DNAAF5 DNAAF4 PKD1 CLUAP1 CFAP410 RP1-2 FAM161A TMEM138 MAK CFAP298;CFAP298-TCP10L ANKS6 CCNQ CCNO INTU AK7 SPATA7 GLIS2 PKHD1 CNGA1 NPHP1 CEP78 PLK4 NME7 NEK8 NEK9 CNGB1 DNAH11 DCDC2 C8orf37 ARL2BP TMEM237 UNC119 DRC1 DNAL1 PKD2 FLCN HYDIN TAPT1 ZNF423 IQCB1 CCDC39 DNAI2 DDX59 CFAP52 KIF7 POMGNT1 TOPORS RP2 NME9 EFHC1 ZMYND10 CFAP53 KIZ GAS8 CCDC40 KATNIP CCDC103 DNAH6 PKD1L1 RSPH9 TULP1 POC1A PDE6D POC1B RAB28 DNAI1 SMO TUB RSPH4A PCARE LCA5 RP1L1 RPGRIP1 RSPH3 RSPH1 TTLL5 KIAA0586 KIAA0753 ALMS1 CENPF SPAG1 HYLS1 CCDC65 CEP41 OFD1-1 B9D2 ATXN10 TRIM32 CEP290 GPR161 OCRL PIK3R4 TRAF3IP1 USP9X THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260810%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling RB1 MAP2K3 CDKN1B PLD1 CCND3 PIK3R2 PIK3R1 MTOR MAP2K2;MAP2K1 BRAF PIK3CA RAP1GAP MAPK1 AKT1 RAF1 CCNE1 JAK2 MAP2K6 HRAS MAPK3 RPS6KA1 RPS6 RPS6KB1 ADCY3 ADCY2 GNAO1 CREB1 GNAI3 GNAI1 GNAI2 CDK4 CDK2 RAP1B RAP1A SRC CGA GNA13 TSHR GNB1 GNA12 GNAQ PLCB1 PDE4D-1 MAPK14 RBL2 GNG2 TSHB SCRIB KCNIP3 APEX1 RALGDS PDPK1 MYL12B GNAS-1 JAK1 STAT1 IGF1R STAT3 RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260810%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis MLST8 AKT2 AKT3 MTOR PTEN PIK3CA RIOK2 RIOK1 TP53 AKT1 RPL11 EGFR FOXO3 MAPKAP1 RICTOR PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260810%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing CGAS IFNB1-4 OAS1 IRF3 STING1 MAVS ADAR RNASEH2C RNASEL RNASEH2B RNASEH2A TREX1 IFIH1 RNASET2 SAMHD1 DDX58 ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260810%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD PTGS2-2 RB1 LPL PLAGL1 CDKN1B RET AIP NQO1 CCL1 MAP2K2;MAP2K1 GCLC NFE2L2 ARNT ESR1 KRAS CDKN1A MAPK1 HSP90AA1 RAF1 FGF21 CD36 KLF6 NF1 EGFR NRIP1 PSRC1 HRAS NCOA7 E2F1 CYP1A2 TNF VEGFA NFKB1 NRAS HPGDS CDK2 AHR AHRR SRC NCOR2 CDC37 CYP1A1 MYC CYP1B1 RELA EP300 CANCER PATHWAYS%WIKIPATHWAYS_20260810%WP5434%HOMO SAPIENS Cancer pathways RB1 CDKN1B PIK3CD PIK3R3 E2F3 CCND3 PIK3R2 CCND2 PIK3CB PIK3R1 MTOR MAP2K2;MAP2K1 PIK3CA TXNRD1 MAPK1 AKT1 CCNE2 RAF1 CCNE1 MDM2-2 MAPK3 E2F1 ABL1 PMAIP1 GADD45B GADD45A LAMA2 PML LAMA1 GADD45G LAMA3 RARA ROCK1 LAMC2 CDK6 LAMB3 AKT2 RAD51 LAMB1 AKT3 CDK4 CDK2 CALML6 RHOA CALML3 PTK2 CALML4 PLCB3 PLCB4 IL23A FRAT2 GNAQ PLCB1 PLCB2 RASGRP1 IL12RB1 IL12RB2 MSH2 TRAF4 BRCA2 POLK RALB TGFA PLD2 APC2 E2F2 MLH1 BAK1 RALGDS CAMK2G IL15 KLK3;KLK2 LAMB2 LAMA4 FN1 LAMC1 EGLN2 COL4A2 MMP2 MMP3 COL4A1 IL2 BIRC2 BIRC3 PTGS2-2 HDAC2 IL5RA HDAC1 IL2RG IL5 IL2RA IL2RB LPAR4 GNA11 APPL1 RXRB RXRA CASP3 KIF7 RAC1 EDNRA GNAI3 ARHGEF12 GNAI1 PRKCA LPAR6 GNAI2 KNG1 TP53 BDKRB2 BDKRB1 DAPK1-1 AGT AGTR1 SMO FZD10 JUN WNT5B F2 CRK CTBP2 TCF7 GSK3B TGFBR1-1 WNT6 DVL1 IKBKB DVL2 VHL DVL3 WNT3 IKBKG WNT4 FZD1 WNT10B WNT10A FZD3 FZD2 FZD7 FZD6 CHUK GSTO1 FZD9 DAPK2 DAPK3 TFG CAMK2D EML4 CSF2RB MAPK8 MECOM GSTO2 PAX8 RUNX1T1 PLEKHG5 TGFB1 CCDC42 AXIN1 WNT9B HHIP EGF RUNX1 AXIN2 IGF1 PTCH2 NFKB1 ARHGEF11 WNT16 IL7 RASSF1 LEF1 LRP5 RASSF5 FGFR2 LRP6 CXCR4 PTCH1 WNT11 TCF7L2 WNT7A STAT6 JAK1 BMP2 IL4R GSTM4 STAT1 RASGRP2 RASGRP4 MMP1 STAT3 IGF1R CRKL RASGRP3 CDH1 IL4 GNB5 PLD1 FGFR1 ITGB1 MST1 CUL1 CREBBP SKP1 SMAD4 HMOX1 NCOA3 ADCY4 FOXO1-1 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CSF2RA ADCY9 EGLN1 KEAP1 HIF1A ALK CSF1R TRAF5 WNT2B NOTCH1 EPO PDGFB PDGFA FGF1 RARB SHH ITGA3 EDN1 WNT1 WNT2 IL6R TERT COL4A4 COL4A3 TGFB3 COL4A5 WNT3A WNT7B CCDC6 HGF WNT5A FLT3LG CAMK2B LAMA5 GSTP1 JAG1 VEGFA BMP4 IL3 IL6 KITLG KIT GSTM3 NCOA4 IL12B IL12A IFNAR2 IFNAR1 FADD NFKB2 NFKBIA MAX WNT9A WNT8B CAMK2A CXCL8 PRKACB-1 IGF2 CASP8 FOS TRAF3 TRAF6 GSTA3;GSTA5;GSTA1;GSTA2 GNA13 GNA12 ARHGEF1 RELA MAPK9 SPI1 MAPK10 AR SMAD2;SMAD3 PPARG IL13RA1 SLC2A1 EPAS1 LPAR2 LPAR3 GNG10 GNG13 LPAR5 GNB3 GNGT1 RET CUL2 VEGFB ELOC-1 KRAS EGLN3 VEGFC VEGFD CSF3R NKX3-1 PPARD IL13 PDGFRB DCC MSH3 PDGFRA F2R ITGAV PGF COL4A6 FH HES1 ELK1 HES5 GNB2 GNB1 GNB4 IL7R HSP90AB1 LAMC3 PLCG2 PLCG1 NOTCH2 IL3RA XIAP GNG2 GNG5 GNG4 CASP9 GNG8 CASP7 CXCL12 MGST3 HSP90AA1 MGST1 MGST2 PTGER4 NOS2 PTGER1 PTGER2 PTGER3 CBL IFNG ITGA2B RBX1 CTNNB1 ARAF GSTA4 FGFR4 MYC FGFR3 FLT3 FLT4 EP300 PRKCG PRKCB STAT5A STAT5B ITGA2 TGFB2 BRAF ITGA6 BCL2 GRB2 CDKN1A GSTA3;GSTA1 MET FASLG JAK2 CTNNA1 JAK3 HRAS APAF1 GSTT2B;GSTT2 NTRK1 DDB2 TGFBR2 BIRC5 SOS1 SOS2 TXNRD3 CYCS-1 NRAS STAT4 BID MSH6 BAD STAT2 GSTM1;GSTM2-1 FAS BAX RALBP1-1 RAC3 RALA-1 IFNGR1 IFNGR2 EPOR EDNRB IL6ST CTNNA3 PIM1 ARNT2 ETS1 CTBP1 MITF NOTCH3 NOTCH4 TXNRD2 JUP FZD5 FZD4 ZBTB16 HEY2 FZD8 F2RL3 WNT8A DLL1 GLI2 ARNT DLL3 DLL4 ROCK2 GLI3 BCR SKP2 CTNNA2 JAG2 HEY1 NCOA1 TCF7L1 CCNA2-1 HEYL TPR SP1 ESR1 CEBPA CDKN2B CDKN2A EGFR CCND1 ERBB2 TPM3 ESR2 BCL2L1 BBC3 RXRG HSP90B1 BCL2L11 TRAF1 NQO1 NFE2L2 PRKACA-1 RPS6KA5 PIM2 RPS6KB1 RPS6KB2 TRAF2 LPAR1 GLI1 CCNA1 APC PTEN CKS1B BIRC7 ELOB ZBTB17 LAMB4 GNAS-1 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260810%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma MAP1LC3B2;MAP1LC3B-1 PINK1 SQSTM1 BECN1 AGER NFKB1 VMP1 IPO8 TFE3 NFE2L2 MITF ATG7 HMGB1-1 SHOC2 KRAS TP53 TFEB STAT3 MDM2-2 PRKN METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260810%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II NAT10 CYP11B1;CYP11B2 NAT14 CYP21A2 HS2ST1 SULT1C3 AKR1B15;AKR1B10 CYP4V2 UGT2A1 SULT4A1 GAL3ST3 GAL3ST4 CHST8 HS3ST3B1 CHST9 CHST6 NAA30 CHST7 KCNAB1 KCNAB2 CYP7B1 KCNAB3 CYP2C9;CYP2C19 NAA40-2 CHST1 NAT8L CHST4 CHST2 CHST3 NAA20 NAA50-1 HS3ST2 CYP2F1 NAT8-2 CYP4B1 FMO2 HS3ST5 HS3ST6 FMO4 HS3ST4 HS3ST1 SULT1B1-1 CYP20A1 CYP26B1 SULT2B1 CYP26A1 FMO3 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 EPHX2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2C18-1 AKR1D1 SULT2A1-4 MGST3 MGST1 MGST2 CYP7A1 CYP2S1 NNMT TPMT CYP1A2 SULT1C2 HNMT INMT GSTP1 GPX4 GPX5 GSTM3 FMO5 BAAT GSTA4 GSS CYP8B1 CYP2A13;CYP2A6;CYP2A7-1 GSTZ1 AKR7A2 GSTA3;GSTA1 AKR1B1 CYP2E1 GSTT2B;GSTT2 CYP27A1 CYP2W1 CYP27B1 CYP24A1 CYP2R1 AKR7A3 CYP2B6 GSTM1;GSTM2-1 GSTA3;GSTA5;GSTA1;GSTA2 EPHX1 CYP1A1 AKR1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1B1 GLYAT CYP2J2-1 COMT GSTO1 CYP46A1 GSTO2 CYP51A1 GSR UGT1A1;UGT1A6 CYP2D6;LOC107987479;LOC107987478-1 HS6ST1 HS6ST2 HS6ST3 NAA80 NDST2 NDST1 NDST4 NDST3 GSTK1 CYP39A1 CYP2U1 SULT6B1 HS3ST3A1 GSTCD GSTM4 CYP4F22 CYP19A1 CYP4X1 CHST12 CYP17A1 CHST11 CHST10 CHST13 CHST14 CYP27C1 NAT9 CYP11A1 GAL3ST1 MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260810%WP2003%HOMO SAPIENS miR targeted genes in leukocytes SLC7A6 PTRH1 DNAJB1 POLR2C SRSF10 PISD WDR11 TUSC2 PKM TXNRD1 AP3D1 SHOC2 ARCN1 CDIPT ATP6V0E2;ATP6V0E1 FMNL2 CORO1C RAB6A SAC3D1 HMOX1 CD164 BCL6 SLC25A1 ADPGK TNFSF9 SLC7A11 ACP2 SNAP23 PRSS21 CA12 CDK6 UNC93B1 CAP1 TMEM43 CHORDC1 IFRD1 KCNN4 ATP6V0A1 SNX6 ANXA2 MPDU1 LPL MCL1 TMED3 ANAPC1 CTSC RHOG GAK CDCP1 FRG1 BRPF3-1 CEBPB CAPG C1orf56 USP1 ARID4B TPM3 TXN2 ARHGDIA WDFY1 MATR3 PPIB SLC1A4 IGF2R PPIF TNFAIP2 MAP3K8 MTHFD2 TMEM109 THBS1 SCYL1 CTNNB1 RFT1 TYMS BCL2 YWHAQ G6PD FADS1 LAMTOR3 GNAI2 POLE4 GNA13 PTPA PLXND1 DCAF7 MAPK14 ACAA2 ARF4-1 ANPEP GOLGA7-1 PDLIM5 ZEB1 RAB34 TMED10 ADIPOR2 RTN4 SEC24A MRPL20 SERPINE2 LMNB2 ATP6V1F CDK5RAP1 IDH1 VPS39 CDK5RAP3 TBCA HNRNPM TRAM1 ATP2A2 RAB5C ADAR MRC2 RDH10 GYS1 TUBA1A SPTLC1 SH3BGRL3 PHC2 SFXN1 PRPF40A DDX5 POM121;POM121C CSRP1 PNP-1 NELFCD 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome RB1 UBIAD1 ACACA GRIP1 SNAP25 ABHD11 DLD GAPDH-1 MAPK3 CLTC PCNA DDX21 ATP5MC2 ATP5MC3 ATP5MC1 ATP5F1A ATP5F1B VAMP2 UBE2E3 CLIP2 DNAJC30 FKBP6 VPS28 CFL1 ATPAF2-2 CLASP1 FBLN2 ATP5PB FBLN5 HOXC8 LIMK1 ATP5F1D SMARCA5 ATP5PO UBE2L6 TBL2 GTF2IRD1 CHTF18 BCL7B BUD23 VPS9D1 VPS37C VPS37D MYO1C VPS37A HSPA2 VPS37B BAZ1B METTL27 ATPAF1 MVB12A ACACB SF3B1 CDKN1C CLASP2 TRIM74;TRIM73;TRIM50 TMEM270 DEK WNT2 BECN1 USF1 BRD4 STX1A CTNNB1 ERCC6 CLDN3 MYC EIF2A BTK GTF2I UBE2E1 EIF2AK3 SQSTM1 ATF4 HDAC2 HDAC3 TSG101 HDAC6 GRB2 OGDH NUP62 RFC5 RFC2 FAS EIF4H LAT2 CLDN4 PKLR PRKG1 DLST FZD9 NRG1 MYBBP1A FBN1 CLDN1 ULK1 CLDN5 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260810%WP727%HOMO SAPIENS Monoamine transport and regulation MAPK14 RBL2 NECTIN2 TSC2 AMPH SLC5A7 DBH SLC6A1 CDC25C TH PPP2CB;PPP2CA ITGB3 ACHE TNFRSF11B HRH3 SLC6A2 TNF SLC6A3 FBXO32 ADORA2A IL1B TPH2 UNC13B IL1R1 TGFB1I1 NOS1 STX1A SCAMP2 SLC6A4 TDO2 AGT SYN1 IL6 SIGNALING%WIKIPATHWAYS_20260810%WP364%HOMO SAPIENS IL6 signaling PTPN11 JUNB SOCS3 PRDM1 GSK3B PIK3R2 HDAC1 NR2F6 PIK3R1 MAP2K2;MAP2K1 MAP3K7 GRB2 MAPK1 AKT1 MAP2K4 GAB1 IL6ST IL6R JAK2 MAPK3 SHC1-1 CREBBP TYK2 PRKCD RPS6KB1 CRP TIMP1 SOS1 RAC1 IL6 IRF1 BAD NLK VIP JAK1 BCL2L1 AGT STAT1 HCK STAT3 VAV1 NCOA1 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260810%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders ETFDH ETFA COQ9 APTX COQ7 COQ6 SLC52A1;SLC52A2 COQ2 FLAD1 RFK PDSS2 PDSS1 COQ8A MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260810%WP3877%HOMO SAPIENS MYD88 distinct input output pathway TIFA NFKB1 IRAK1 TLR1 TRAF6 IL1A TLR9 TLR8 TLR7 TLR10 TLR6 TLR5 MYD88 TLR4 UBE2N TLR2 UBE2V1 JUN MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260810%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress PTGS2-2 PINK1 ATF2 MAP2K3 TSC1 NQO1 CHEK1 MTOR PIK3CA NFE2L2 BCL2 CDKN1A AKT1 CCNE1 RHEB RPS6KA5 MAP3K5 MDM2-2 CXCL8 CAT HMOX1 TNF FOXO1-1 ICAM1 CREB1 FOS SIRT1 CDK2 IL1A TP53 ATR CUL3 KEAP1 MAPK14 IKBKB NOX1 PTEN IKBKG MAP2K4 IPCEF1 NRF1 NOS2 PIP-1 GSX1 SOD2 MAPK8 NFKB1 IL6 BCL2L1 IL18 SIGNALING%WIKIPATHWAYS_20260810%WP4754%HOMO SAPIENS IL18 signaling PRKCB PRKAA1 IRAK1 PIK3R1 NFATC4 NFKBIA HSPB1 MAPK1 FASLG MYD88 MAPK3 GRIN2B IL37 CASP8 PRKCD TNF RPS6KB1 CASP3 CYCS-1 PRKCA BID TRAF6 TP53 FAS BAX LCK ELAVL1 RELA MAPK9 ACACB GSK3B IL18R1 IKBKB NOX1 PTEN SP1 MAP3K7 CEBPB MEF2A CHUK IL18 TNFRSF1A IMP3 SLC12A3 PARP1 MAP2K7 NFKB1 IL18RAP CSN2-1 IRF1 CTNNB1 NCF1 NCF2 TICAM2 CFLAR GATA1 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260810%WP3929%HOMO SAPIENS Chemokine signaling GNG13 FGR GNB3 PIK3CD PIK3R3 GNGT1 BCAR1 PIK3R2 PIK3CB CCR8 PIK3R1 CXCL14 CCL1 MAP2K2;MAP2K1 PIK3CA XCL1;XCL2 KRAS PPBP ROCK2 MAPK1 AKT1 RAF1 CCL17 MAPK3 CCL25 SHC1-1 CCL24 CCL22 CCL27 ADCY4 CCL26 ADCY3 ADCY2 ADCY1 ADCY8 ROCK1 ADCY7 ADCY6 AKT2 AKT3 ADCY5 RAP1B PTK2 RAP1A GNB2 PLCB3 PLCB4 GNB1 ADCY9 GNB4 PF4;PF4V1-1 PLCB1 CX3CR1 FOXO3 PLCB2 CCL19 CCL20 GNG2 CCL28 GNG5 GNG4 GNG8 CCR3 CCR2 CXCL12 PREX1 TIAM2 PARD3 ELMO1 DOCK2 PRKX CSK GRK2 CXCR2 WASL NCF1 CDC42 PAK1 CXCL2;CXCL3;CXCL1-1 VAV1 VAV2 TIAM1 PRKCB CCL3L1;CCL3L3;CCL3;CCL18 VAV3 PIK3R5 STAT5B BRAF NFKBIA CXCL10 GRB2 ARRB1 CXCL11 ARRB2 CXCL9 JAK2 GRK6 JAK3 HRAS PIK3CG PRKACB-1 PRKCD SOS1 RAC1 SOS2 CX3CL1 GNAI3 CCL23;CCL15 GNAI1 NRAS GNAI2 STAT2 NFKBIB CXCL13 CXCR5 CCL21 PTK2B GRK1 RELA CCL4L2;CCL4L1;CCL4 CCL5 CRK GSK3B PXN PRKCZ CXCR3 WAS IKBKB IKBKG GRK5 GRK4 CHUK CCR10 CCR1 LYN ITK XCR1 NFKB1 SHC4 CCL11 SHC2 CCR9 CXCR4 SHC3 CCR7 CCR6 CXCR6 CCR4 RASGRP2 HCK STAT1 STAT3 CRKL CXCL5;CXCL6 GNB5 GNG10 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260810%WP5526%HOMO SAPIENS Age related macular degeneration RPS6KB1 MLST8 PRKAG1 PRKAG2 PRKAA1 PRKAG3 MDH1 PPARGC1A SIRT1 PRKAA2 MTOR PRKAB2 PRKAB1 PARP2 RPTOR MAPK3 PMAIP1 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260810%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism PTGS2-2 EPHX2 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260810%WP5304%HOMO SAPIENS Cholesterol metabolism DGAT1 SLC27A4 SOAT1 LRP1 APOA4 PLTP NPC1L1 NPC1-1 LIPA CD36 NPC2 MVD CYP27A1 DHCR7 TSPO LBR SORT1 ANGPTL8 ANGPTL3 ABCA1 CETP SCARB1 MTTP APOA2 LPL HMGCS1-1 LCAT PCSK9 VDAC1 APOA1 LIPC LSS APOC2 LIPG ABCB11 APOE LDLRAP1 IDI1 APOB LDLR HSD17B7 SAR1B CYP7A1 MVK MGAT1 FDFT1 ABCG8 MSMO1 ABCG5 FDPS APOC3 ACAT2 APOC1 TM7SF2 EBP NSDHL PMVK SC5D CYP51A1 MYLIP SQLE LRPAP1 APOH OSBPL5 CIDEB DHCR24 FABP2 STARD3 HMGCR VAPA STAR MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260810%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway ITGB2 ARPC1B VAV3 CYBB CYBA PIK3CD C1QB PIK3R3 PIK3R2 LAT PIK3CB PIK3R1 PTPN6 PIK3CA PIK3C2A C1QC PIK3R6 PIK3C3 TREM1 LYN PIK3CG SYK NCKAP1L RAC1 TREM2 FCGR1A SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 HCK NCF1 NCF2 RAC3 NCF4 VAV1 FCER1G VAV2 ITGAM TYROBP PLCG2 FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260810%WP5102%HOMO SAPIENS Familial partial lipodystrophy FABP4 LPL SREBF1 STAT5B INS;INS-IGF2 KLF2 PIK3CA CEBPA PNPLA2 PPARA KLF5 LIPE ICMT PLIN1 LMNB2 LMNB1 ZMPSTE24 FNTA LMNA AKT2 CIDEA PPARG BANF1 CIDEC MGLL PRRX1 GATA3 GATA2 KLF9 MAPK9 BENZENE METABOLISM%WIKIPATHWAYS_20260810%WP3891%HOMO SAPIENS Benzene metabolism GSTM1;GSTM2-1 EPHX1 NQO1 DHDH CYP2E1 MPO MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260810%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ECI1 ACADSB HSD17B10 ACAA2 EHHADH-1 ACSL3 DECR1 ECHS1 ACADL MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260810%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness PLCG1 ITGAV CREB1 PRKCQ TNNC1 RYR3 PTK2 MFAP5 MAPK1 MAPK3 ITPR3 ITGB3 JUN MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260810%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism UGT1A1;UGT1A6 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SRD5A2 HSD17B3 CYP19A1 CYP17A1 HSD17B2 SRD5A1 HSD3B1;HSD3B2 CYP11A1 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260810%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome ATM SMC1A PAXIP1 MRE11 SMC3 RAD18 RAD21 BRCA1 RAD50 MDC1 NBN HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation FLI1 KLF1 GP9 STAT5A THRB IL5 ITGB3 LYL1 FOS CD34 IL1B IL1A IRF5 SPI1 NOTCH1 CSF1 EPO TPO MYB KCNH2 HES6 PIM1 RUNX1 NFATC2 RHOH NCKAP1L IL3 ITGA2B IL6 LEF1 KITLG FOSB TNXB CXCR4 GATA2 CSF2 CIITA TRAF3IP3 CSF3 IKZF1 HMGN5 TRIM29 LMO2 ACVR1B VAV1 SEC14L2 MUC1 MXI1 NFE2 GATA1 RIOK3 IL4 SIGNALING%WIKIPATHWAYS_20260810%WP395%HOMO SAPIENS IL4 signaling ATF2 FES SOCS3 PIK3CD STAT5A STAT5B PIK3R2 IL2RG PIK3R1 PIK3CA NFKBIA GRB2 MAPK1 AKT1 JAK2 JAK3 MAPK3 SHC1-1 IRS1 TYK2 GAB2 RPS6KB1 FOS SOS1 IRS2 ELK1 BAD INPP5D RELA PTPN11 MAPK14 DOK2 MAPK11 PTPN6 IKBKB CEBPA CEBPB CHUK CBL NFKB1 SOCS1 STAT6 JAK1 SOCS5 IL4R STAT1 FLNA STAT3 IL4 EP300 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260810%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PKD1 PLCG1 PLCD3 PLCL1 PLCH1 FFAR1 PLCZ1 PLCB3 GNA11 PLCB1 PLCD1 ITPR3 PLCB2 PLCG2 PLCE1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260810%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance TNF RPS6KB1 PDX1 MAFA PRKAG3 TRAF1 CPT1B SMPD3 ERN1 IRS2 SLC2A4 PRKCZ PIK3R1 INS;INS-IGF2 EIF2AK2 AKT1 INSR CD36 TNFRSF1A IRS1 MAPK8 PPP2CB;PPP2CA ACSL1 BASE EXCISION REPAIR%WIKIPATHWAYS_20260810%WP4752%HOMO SAPIENS Base excision repair NEIL2 TDG POLE POLD2 MPG OGG1 PNKP UNG APTX NTHL1 MUTYH POLG MBD4 SMUG1 APEX1 PARP3 PARP4 RFC1 NEIL3 XRCC1 POLG2 ADPRS NEIL1 PCNA PARP1 POLD3 POLD4 POLD1 RFC5 RFC3 FEN1 RFC4 LIG1 POLB POLL RFC2 HMGB1-1 PARP2 POLE4 LIG3 POLE2 TDP1 POLE3 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260810%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials PORCN CTNNB1 LRP5 CREBBP LRP6 PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260810%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma BRCA1 FBXW7 CHEK2 CHEK1 MAP2K2;MAP2K1 TLK1 PIK3CA SMC1A AKT1 MAX JMJD1C RAF1 MYBL1 CMTR2 MAGI1 BRD1 PRKDC HRAS INSRR MORF4L1-2 CREBBP FOXP2 KAT6A SRCAP MGA MYCBP-1 ATRX ARID5B H2AC16;H2AC11 H1-4 KANSL1 MYCN BCORL1 KDM6B FGF16 TP53 ATM IL17RD SETD2 NSD1 FOXO3 CNTN6 KDM6A NOTCH1 BCOR PTEN MAGI2 CEBPA KMT2C MYB ERBIN UHRF1 NCOR1 ERBB2 MAML3 ARID4B CTBP1 SMARCE1 NFIB SMARCA2 ARID1A DTX4 FGFR4 MYC EP300 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260810%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway HMGCL GGPS1 HMGCS1-1 ACAT1 IDI1 MVK FDFT1 IDI2 HMGCR FDPS ACAT2 MVD PMVK AGE RAGE PATHWAY%WIKIPATHWAYS_20260810%WP2324%HOMO SAPIENS AGE RAGE pathway PRKCB ATF2 STAT5A MMP13 STAT5B EZR MAP2K2;MAP2K1 NFKBIA MAPK1 AKT1 RAF1 MYD88 JAK2 MAPK3 SHC1-1 IRS1 CASP8 PRKCD FOXO1-1 MMP9 CASP3 MSR1 MSN INHBB RAC1 IRAK4 ROCK1 TIRAP CYCS-1 PRKCA RHOA DIAPH1 SRC RELA MAPK9 JUN HIF1A MAPK14 MMP14 LGALS3 ALPL PRKCZ CASP9 IKBKB DDOST INS;INS-IGF2 SP1 CHUK NOS2 NOS3 EGFR MAPK8 MMP7 AGER NFKB1 SMAD2;SMAD3 FOXO4 STAT1 NCF1 MMP2 CDC42 INSR STAT3 PLA2G4A SOD1 MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260810%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 MMP9 TP53 BAX SOCS3 IL6ST STAT3 CDH1 MYC E2F1 CHI3L1 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation MAPK14 MAPK12 RBL1 MAPK13 MAPK11 PTHLH MAP2K2;MAP2K1 CNP CDKN1A MAPK1 IHH RAF1 THRA MAPK3 PPP2CB;PPP2CA FGF9 PTH1R BMP4 NPR2 SOX9 ATG5 BMP2 FGF18 STAT1 FGFR3 SNAI1 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260810%WP186%HOMO SAPIENS Homologous recombination POLD3 POLD4 MRE11 POLD1 POLD2 RAD52 RAD54B RAD50 RAD51 BRCA2 RPA1 NBN ATM UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260810%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts PGM1 GCK GFPT1 HK3 HK2 GALE HK1 UXS1 UGDH PGM3 GPI DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260810%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte ZIC1 PPARGC1A SMAD1 SMAD9 SMAD5 PRDM16 CEBPA CEBPB ZNF423 CEBPG BMP4 CIDEA PPARG HSPB7 SLC7A10 PLAC8 HOXC9 MPZL2 EBF3;EBF1 HOXC8 BMP2 ADIPOQ LEP BMP7 PPARGC1B DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260810%WP710%HOMO SAPIENS DNA damage response only ATM dependent CDKN1B PIK3CD PIK3R3 TP73 CCND3 CCND2 PIK3R2 PIK3CB PIK3R1 PIK3CA KRAS MAPK1 AKT1 MDM2-2 SHC1-1 IRS1 SMAD4 ABL1 BCL6 PMAIP1 AKT2 AKT3 RHOA ATM FOXO3 TCF7L1 WNT2B LDLR MAP3K4 BAK1 WNT1 WNT2 CDKN2A WNT3A CCND1 WNT7B ERBB2 WNT5A HMGB1-1 SCP2 CTNNB1 CDC42 INSR BBC3 PCK2 BCL2L11 MYC PIK3R5 NFKB2 BCL2 GRB2 CDKN1A FASLG HRAS CAT PIK3CG SOS1 RAC1 SOS2 NRAS BAD TP53 MLKL BIK BAX CCNG2 RAC3 PLAU JUN MAPK9 WNT5B PDK1 RBL2 APC TCF7 GSK3B MAPK10 WNT6 DVL1 DVL2 DVL3 PTEN WNT3 PIK3C2G WNT4 PIK3C2A PIK3C2B MAP3K7 WNT10B WNT10A FOSL1 PIK3C3 MAPK8 PPP2R5E PIK3R4 TGFB1 AXIN1 MAP3K1 PPP2R5C NFKB1 WNT16 SMAD2;SMAD3 LEF1 WNT11 TCF7L2 WNT7A G6PC1 ATR SIGNALING%WIKIPATHWAYS_20260810%WP3875%HOMO SAPIENS ATR signaling RPA3 HUS1 RAD1 ATRIP RAD9A ATR RPA2 RAD9B CHEK1 RPA1 TOPBP1 GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis CYP11B1;CYP11B2 CYP21A2 SRD5A2 CBR1-1 HSD11B1 HSD11B2 SRD5A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 AKR1D1 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260810%WP1971%HOMO SAPIENS Integrated cancer pathway RB1 MRE11 MSH2 CDKN1B NOXA1 BRCA1 CASP9 CHEK2 CHEK1 PLK1 PTEN BCL2 CDKN1A CDC25A AKT1 CDKN2B BARD1 MAP3K5 MDM2-2 E2F1 CASP8 BACH1 CASP3 RAD50 SMAD2;SMAD3 ATF1 CDK4 CDK2 MSH6 CDK1 BAD ATM TP53 BAX JAK1 ATR POU2F1 STAT1 MMP1 BBC3 MYC CDC25B BLM EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260810%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells DKK4 APC TGFB2 TGFBR1-1 MTOR TGFA KRAS MET AKT1 RAF1 EGFR TGFB3 HRAS WNT3A TGFBR3 SMAD4 MFGE8 ERBB2 HGF WNT5A TSPAN8 TGFB1 AXIN1 TGFBR2 SMAD2;SMAD3 NRAS PROM1 CTNNB1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260810%WP185%HOMO SAPIENS Integrin mediated cell adhesion CAV2 MAP2K3 DOCK1 BCAR1 PIK3R2 MAP2K2;MAP2K1 ITGB1 ROCK2 MAPK1 AKT1 RAF1 MAP2K6 SHC1-1 ITGB3 ITGAV ROCK1 CAPN10 AKT2 AKT3 RAP1B PTK2 RAP1A SORBS1 ILK ITGA3 ITGA8 TLN1 VCL CAV1 CSK BUB1B-PAK6;PAK6 ITGA2B ITGB5 CAPN1 ITGA1 CDC42 PAK1 ARAF ITGA10 ITGA11 VAV2 ITGAM ITGB2 ITGB6 ITGAE ITGAL VAV3 ITGAX ITGB8 ITGB7 CAPN3 ITGA4 ITGA2 ITGAD BRAF ITGA7 ITGA6 GRB2 ITGA5 ITGA9 SELENOP PAK3 HRAS PAK2 PAK4 MYPN ITGB4 SOS1 RAC1 RHO MAPK6 SRC MAPK4 CAPN9 CAPNS1 CAPN6 RAC3 CAPN7 CAPN5 TNS1 ARHGEF7 FYN GIT2 CAPN11 CRK MAPK12 MAPK10 PXN PDPK1 CAPN2 MAPK7 MAP2K5 SHC3 VASP RAPGEF1 CAV3 ZYX MYLK2 ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260810%WP2374%HOMO SAPIENS Oncostatin M signaling PRKCB CDKN1B SOCS3 STAT5B OSMR PIK3R1 MTOR MAP2K2;MAP2K1 NFKBIA OSM GRB2 KRAS MAPK1 AKT1 RAF1 LIFR JAK2 JAK3 HRAS MAPK3 SHC1-1 IRS1 RPS6 TYK2 RICTOR PRKCD CASP3 CREB1 FOS SOS1 PRKCA CDK2 SRC PTK2B RELA PRKCH MAPK9 HIF1A PRKCE PTPN11 MAPK14 JUNB JUND PXN CASP7 CEBPB PIAS3 IL6ST MAPK8 VEGFA NFKB1 EGR1 JAK1 STAT1 STAT3 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260810%WP5294%HOMO SAPIENS Sildenafil treatment PPARGC1A GSK3B TFAM-1 AKT2 PDE4B AKT3 PDE4A GUCY1A2 GUCY1A1 PDE4C PDE5A NOS1 PRKG1 GAPDH-1 AKT1 NOS2 NRF1 GUCY1B1 NOS3 PRKN PDE4D-1 ZNF746 UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260810%WP5158%HOMO SAPIENS Urotensin II mediated signaling ESPL1 CYBB HDAC5 CYBA AIFM2 COL2A1 DDIT3 NPPB BCL2 MAPK1 AKT1 CCNE1 PRKACA-1 JAK2 CAMK2A MAPK3 CREBBP PCNA HMOX1 ALOX5 TNF MMP9 ICAM1 CASP3 IRF3 IL1B CDK2 CDK1 RHOA BAX AGTR1 ABCA1 HSPA2 RELA UTS2R MAPK9 TRPC4 VCAM1 GSK3A FSCN1 PTPN11 MAPK14 COL1A1 GSK3B CASP9 IKBKB PTEN NPPA CHUK EGFR MAPK8 TGFB1 NFKB1 IL6 SMAD2;SMAD3 FN1 COL3A1 CTNNB1 NCF1 MMP2 NOX4 NCF2 STAT3 NCF4 ACTA2 EP300 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260810%WP4571%HOMO SAPIENS Urea cycle and related diseases GLS2 NAGS OTC SLC25A13 ARG1 ASS1 SLC25A15 CPS1 ASL MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260810%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer DDB2 SHISA5 CYS1 EI24-1 CASP3 SESN3 ZMAT3 CASP9 PERP CHEK2 PTEN BID SERPINE1 ATM TP53 SIAH1 BAX BBC3 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MDM2-2 APAF1 CASP8 PMAIP1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260810%WP47%HOMO SAPIENS Hedgehog signaling GLI1 ARNTL PTCH2 KIF7 DHH STK36 SAP18 SIN3A GRK2 PTCH1 GLI2 SHH IHH SMO GLI3 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260810%WP100%HOMO SAPIENS Glutathione metabolism GCLM IDH1 OPLAH GPX1 ANPEP GPX4 GCLC GSTM1;GSTM2-1 GSTA3;GSTA1 GSTA3;GSTA5;GSTA1;GSTA2 GGT1 G6PD GSS GGT5 GSTT2B;GSTT2 GSR THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260810%WP4297%HOMO SAPIENS Thiamine metabolic pathways BCKDHA PDHA1 BCKDK SLC25A19 TPK1 OGDH SLC19A2 SLC19A3 TKT ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5275%HOMO SAPIENS Ether lipid biosynthesis PEX19 PEDS1-UBE2V1;PEDS1 ALDH3A2 CEPT1 GNPAT FAR1 PEX16 LPCAT1 AGPS PEX1 LPIN1 PEX7 LPIN2 PEX5L PEX3 DHRS7B UGT8 AGMO DGKQ FAR2 ACAD10 LPIN3 ARSA GAL3ST1 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP560%HOMO SAPIENS TGF beta receptor signaling ITGB6 SMAD1 SMAD9 SMAD5 SMAD6 ZEB2 ZFYVE9 TGIF1-1 HRAS MAPK3 LIF TGFBR3 CREBBP ENG SMAD4 LTBP1 TNF FOXH1 ZNF423 FKBP1A TGFBR2 SKI BAMBI FOS TFE3 SERPINE1 MAPK9 JUN SPP1 TGFBR1-1 WNT1 FST LEFTY2;LEFTY1 SMAD7 RUNX3 NOG TGFB1 INHBA EGF IFNG NFKB1 BMP4 LEF1 SMAD2;SMAD3 JAK1 THBS1 STAT1 CTNNB1 STAT3 RUNX2 SKIL EP300 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260810%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway TNF CCL3L1;CCL3L3;CCL3;CCL18 TMPRSS2 IL7 ACE2 IL6 IL10 IL1B IL2RA CXCL10 CCL13;CCL2 AGT CSF3 CXCL8 IL2 MRNA PROCESSING%WIKIPATHWAYS_20260810%WP411%HOMO SAPIENS mRNA processing CLK4 CLK3 LSM2 SRPK1 HNRNPL SRSF10 CLK1 LSM7 DICER1 HNRNPK RNPS1 CLASRP HNRNPC SUGP2 SUGP1 CELF1 SFPQ-1 CELF2 CELF4 SRP54 YBX1 SNRNP70 SMC1A DHX16 RBM5 CPSF2-1 RBM17 PRMT2 NCBP1 PRPF18 HNRNPH1 SUPT5H SNRPA1 HNRNPH2 DNAJC8 HNRNPA1-1 SF3B4 SF3B5 SF3B2 SF3B3 SFSWAP PTBP1 SRSF1 DDX20 CSTF2T PTBP2 PPM1G NXF1 NONO U2AF2 TRA2B SPOP SNRPB2 SNRPG-2 RBM39 SF3A1 SRSF4-1 RNGTT SNRPN SF3A2 HNRNPAB NUDT21 NCBP2-1 SNRNP40 PHF5A HNRNPA2B1 PABPN1-1 CLK2 RBMX SF3B1 DHX15 PRMT1 SRPK2 SF3A3 FUS RNMT POLR2A HNRNPU METTL3 DHX9 HNRNPD SRSF9 TMED10 U2AF1L5;U2AF1 HNRNPR EFTUD2 SNRPD2 SNRPD1 CLP1 PAPOLA SNRPD3 TXNL4A PSKH1 PRPF4B CDC40 SRRM1 PRPF4 PRPF6 PRPF3 HNRNPM XRN2 PCBP2 SRSF2 SRSF3 CD2BP2 SREK1 SRSF5 SNRPF SRSF6 SRSF7 SNRPA SNRPB DHX8 CSTF3 DDX1 CSTF2 SNU13 PRPF40A PRPF8 DHX38 SNRPE-2 CPSF4 CPSF1 CPSF3 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260810%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection IFNAR1 TMPRSS2 OAS1 ACE2 IRF9 MAVS IKBKE EIF2AK2 IFIH1 MYD88 DDX58 TYK2 IRAK4 IRF3 TRAF3 TRAF6 STAT2 TLR9 TBK1 IRF7 JAK1 TLR7 IFNAR2 TLR6 STAT1 TLR4 TLR3 TREML4 TLR2 OAS3 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260810%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways FZD5 FZD4 CDKN1B STAT5A FZD8 MAP2K2;MAP2K1 GRIA1 GRB2 CDKN1A ROCK2 PFN3 MAPK1 AKT1 RAF1 NEFM NEFH SHC1-1 ACTR2 PIK3CG SOS1 CAMK1 PFN1 ACTA1 ELK1 NEFL RHOA MYL1 PTK2 SRC FZD10 DAAM1 PFN2-1 ACTR3-1 JUN PLCG1 APC GSK3B NCK1 DVL1 TGFA FZD1 FZD3 FZD2 MAP2K4 FZD7 FZD6 FZD9 EGFR MAPK8 PPP2CB;PPP2CA ERBB4 ERBB2 AXIN1 CBL MYLK WNT16 GPX1 WNT11 FN1 NOS1 CTNNB1 PAK1 MYC SOD1 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260810%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary KISS1R PRKCG PRKCB PRKCE GDF9 PDK1 AMH PRKCQ PIK3CD PIK3CB MAP2K2;MAP2K1 PIK3CA ARRB1 KRAS ARRB2 MAPK1 AKT1 RAF1 KISS1 FSHR HRAS MAPK3 PIK3CG PRKCD MMP9 NFKB1 AKT2 NRAS PRKCA PLCB3 PLCB4 PLCB1 PLCB2 HSD3B1;HSD3B2 STAR BMP15-1 CYP11A1 PRKCH OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260810%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis ACOT2;ACOT1 FADS1 ACSL3 ELOVL2 PLA2G5 PLA2G6 ACSL4 JMJD7-PLA2G4B;PLA2G4B ELOVL5 ACOX3 PLA2G4A FADS2 ACSL1 ACOX1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2B6 CYP2C9;CYP2C19 CYP2C18-1 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260810%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer MAPK1 JAK1 STAT3 EGFR MAPK3 DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260810%WP5173%HOMO SAPIENS Disorders of galactose metabolism GALT GBE1 PGM1 PYGL GYG2 GYS2 GALK1 SLC5A1-1 GALE GYS1 AKR1B1 GYG1 SLC2A2 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260810%WP5174%HOMO SAPIENS Ulcerative colitis signaling TNF TGFB1 FOXP3 NOD2 NFKB1 IFNG HLA-DMA IL10 IL2RG NFATC1 IL5 GATA3 STAT6 IL4R TLR2 IL13 MAF IL4 CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260810%WP4562%HOMO SAPIENS Canonical NF kB pathway CHUK NFKB1 NFKBIE IKBKB REL RELA NFKBIA IKBKG IL5 SIGNALING%WIKIPATHWAYS_20260810%WP127%HOMO SAPIENS IL5 signaling GSK3A PTPN11 STAT5A STAT5B GSK3B IL5RA PIK3R2 PIK3R1 MAP2K2;MAP2K1 GRB2 KRAS MAPK1 AKT1 RAF1 JAK2 MAPK3 SHC1-1 RPS6KA1 CSF2RB LYN PIK3CG RPS6 RPS6KB1 RPS6KB2 SYK SOS1 SPRED1 ELK1 JAK1 STAT1 STAT3 MAPT FOXO3 IL2 JUN BTK CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260810%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy HIF1A AGPAT2 DGAT1 CAV1 CAVIN1 GPAT3 BSCL2 AKT2 INS;INS-IGF2 PIK3CA LPIN1 GRB2 LPIN2 LPIN3 IRS1 FYN DGAT2 ITGB4 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260810%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes FABP4 SLC27A4 PCSK9 VDAC1 APOC2 APOE LDLRAP1 SLC27A3 APOB LDLR SOAT1 SOAT2 LRP1 ACSL6 ACSL5 APOA4 LIPA NPC2 APOC1 ACSL1 MYLIP OSBPL5 ACSL3 FABP2 SLC27A1 SORT1 STARD3 ABCA1 SCARB1 FABP1 STAR FABP3 SLC27A2 DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260810%WP5506%HOMO SAPIENS Disorders of NAD metabolism CD38 BST1 NAXE NAXD NADSYN1 GDNF SIGNALING%WIKIPATHWAYS_20260810%WP5143%HOMO SAPIENS GDNF signaling FMOD GASTRIN SIGNALING%WIKIPATHWAYS_20260810%WP4659%HOMO SAPIENS Gastrin signaling TCF4 CDKN1B PIK3R3 BCAR1 PIK3R2 PIK3R1 MTOR MAP2K2;MAP2K1 ITGB1 PIK3CA EIF4EBP1 KRAS MAPK1 AKT1 RAF1 MAP3K11 MAPK3 SHC1-1 IRS1 YES1 FOXO1-1 CREB1 ROCK1 ELK1 RHOA PTK2 GNAQ FOXO3 ELAVL1 ANXA2 PLCG1 SP1 MEF2B;BORCS8-MEF2B ARHGEF28 GAST CHGA CDKN2A EGFR CCND1 KAT5 JAG1 VEGFA KIT TJP1 BCL2L1 KLF4 CTNNB1 CDC42 PAK1 IL2 MYC BIRC2 BIRC3 PTGS2-2 ATF2 SLC9A1 NFKBIA GRB2 ARRB1 HDAC7 CDKN1A ARRB2 HDC PRKACA-1 JAK2 HRAS CXCL8 RPS6 PRKCD RPS6KB1 LAMTOR3 CASP3 BIRC5 FOS SOS1 RAC1 SERPINB2 PRKCA SERPINE1 BAD RHOD RHOB SRC MEF2D CCKBR FYN RELA PRKCH JUN MAPK9 PRKCE PTPN11 MAPK14 PRKCQ CRK GSK3B PXN IKBKB PRKD2 CHUK PRKD1 MEF2C MAPK8 SLC9A3 MMP7 NFKB1 CD44 PPARG EGR1 BMP2 CLDN1 STAT3 CDH1 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway BIRC3 ETNK2 PTGS2-2 ACKR3-2 FGD4 BHLHE40 SCNN1A SNAI2 SLC26A2 ABHD2 NFKB2 DNAJC15 NR1I2 CUL1 ARL5B TGFBR3 TNFAIP3 SRGN MFGE8 NAV3 ADGRF4 PTGES3-1 ANKRD1 GADD45B PRRG4 RXRA STOM PPP1R14C SPRY1 PDE4B SLC19A2 LRRC8A CCL13;CCL2 B3GNT5 ANGPTL4 ZIC2 JUN NR1I3 CDKN1C DNER CCL20 S100P POU5F1;POU5F1B ALOX5AP HSP90AA1 AMIGO2 MGAM NR3C1 IL11 SEC14L1 PLK2 CPEB4 EPB41L4B AKAP13 THBD ENC1 EDN2 TNS4 TSC22D3 FGFBP1 SERPINB9 CDC42EP3 PMP2 GPR153 SERTAD2 CAVIN2 KTN1 RGS2 BIRC2 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260810%WP5300%HOMO SAPIENS TROP2 regulatory signaling RB1 CDKN1B NOTCH1 MMP13 ABCC1 PIK3R1 CHEK1 PTEN ITGB1 ACVRL1 BCL2 ITGA5 MDK TACSTD2 RACK1 CDKN2A CCNE1 JAK2 EGFR VIM CCND1 PAK4 PRKCD IGF2 TLN1 IGF1 NFKB1 RAC1 PRKCA CDK4 PECAM1 CDK2 IGF2R FN1 PTK2 BAX SRC STAT1 CTNNB1 PSEN2 CLDN1 IGF1R CLDN7 CDH1 JUN MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260810%WP4842%HOMO SAPIENS Mammalian disorder of sexual development PBX1 AMH DMRT1 DHH FOXL2 SRY RSPO1 MAPK11 EMX2 WNT4 SOX8 AMHR2 PTGDS GATA4 INSL3 RBFOX2 CBX2 FST FGF9 NR5A1 SOX9 FGFR2 WT1 CTNNB1 SRD5A1 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260810%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination MAP3K1 AXIN1 GADD45G ROCK1 FOXL2 GSK3B SRY MAPK11 SOX9 FGFR2 WNT4 RHOA MAP3K4 MAPK1 CTNNB1 FGF9 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260810%WP530%HOMO SAPIENS Cytokines and inflammatory response CD4 IFNB1-4 HLA-DRA CSF1 PDGFA IL5 IL11 IL13 TNF TGFB1 IFNG IL3 IL7 IL15 IL6 IL10 IL1B IL1A IL12B CSF2 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CSF3 CXCL2;CXCL3;CXCL1-1 IL2 IL4 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome ATF2 SMAD1 SMAD9 CUL5 SMAD5 BCL2 DLD UVSSA BMPR1A PCNA DDX21 ARNTL NEO1 SIRT6 CLOCK SIRT1 ELK1 SMARCA5 MYO1C BAZ1B ERCC5;BIVM-ERCC5 SF3B1 DEK JUND NLRP3 ITCH DLST RIF1 FRMPD2 OGDHL MAPK8 EIF4ENIF1 SMARCB1 FAM170B ELOA MEN1 VSTM4 NOG C10orf71 RGMB WDFY4 PARG GDF5 LRRC18 ARHGAP22 HSF4 DRGX MYBBP1A KDM4D C10orf53 CHAT TMEM273 SMARCC2 SLC18A3 BMP2 ERCC8 ERCC6 BMPR1B CDH1 HSF1 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260810%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 NLRP3 NFKB1 TRAF3 PYCARD IL1B RELA CASP1 BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260810%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPTLC1 SPHK2 SPHK1 ASAH1 KDSR SGPP2 SGPP1 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260810%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin CCL4L2;CCL4L1;CCL4 VCAM1 CCL5 CCL3L1;CCL3L3;CCL3;CCL18 STAT5A STAT5B MCL1 ITGA4 CCL8 CXCR3 MAPK11 IL2RG ANGPT1 PIBF1 IL2RB ANGPT2 BCL2 CXCL10 CXCL12 CXCL11 MAP2K4 NR3C1 JAK3 MAPK3 CXCL8 CD69 TNF HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E VEGFA IFNG ESR2 IL3 IL15 IL6 IL10 CX3CL1 NCR1-1 MRC1 SELL CXCR4 MADCAM1 GATA2 GAB3 CCL13;CCL2 PGR JAK1 IL4 ERBB SIGNALING%WIKIPATHWAYS_20260810%WP673%HOMO SAPIENS ErbB signaling PRKCG PRKCB CDKN1B PIK3CD STAT5A PIK3R3 STAT5B PIK3R2 PIK3CB PIK3R1 MTOR MAP2K2;MAP2K1 BRAF PIK3CA EIF4EBP1 GRB2 KRAS CDKN1A MAPK1 AKT1 GAB1 RAF1 PAK3 HRAS MDM2-2 CAMK2A PAK2 MAPK3 SHC1-1 PAK5 PAK4 ABL1 FOXO1-1 RPS6KB1 RPS6KB2 SOS1 NRG2 SOS2 AKT2 AKT3 NRAS PRKCA ELK1 BAD TP53 PTK2 SRC PLCG2 MAPK9 JUN CRK HBEGF GSK3B MAPK10 NCK2 NCK1 TGFA MAP2K4 PDPK1 NRG1 EGFR CCND1 CAMK2D MAPK8 ERBB3 AREG BTC ERBB4 ERBB2 MAP2K7 CBLB CAMK2B CBL EGF CAMK2G BUB1B-PAK6;PAK6 SHC4 SHC2 SHC3 EREG NRG3 NRG4 PAK1 ARAF CRKL BCL2L11 ABL2 MYC SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260810%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides A3GALT2 CERS1 DGAT1 CERS2 ASAH1 B4GALT1 CERK DES SGMS1 CERS5 SGMS2 SPTLC1 B3GNT5 A4GALT UGT8 SPHK1 UGCG KDSR CERS3 CERS4 CERS6 B4GALNT1 KETOGENIC DIET IN EPILEPTOGENESIS%WIKIPATHWAYS_20260810%WP5639%HOMO SAPIENS Ketogenic diet in epileptogenesis HMGCS1-1 HDAC2 HDAC3 GLUD1;GLUD2 HDAC1 HDAC8 TXNIP NFE2L2 NLRP3 NRG1 CAT ERBB4 RPS6 SLC25A14 HCAR2;HCAR3 GAD1 SLC25A27 SIRT4 PPARG AKT3 UCP2 SLC2A1 PPID KCNA1 KCNJ11 ABCC8 LDHA AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260810%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction MYLK ROCK1 GDI1 CALM1 PPP1CB RHOA CD38 MYL1 ROCK2 GNAQ RYR1 PLCB1 IL13 ITPR3 ADRB2 PPP1R14A RANKL RANK SIGNALING%WIKIPATHWAYS_20260810%WP2018%HOMO SAPIENS RANKL RANK signaling SQSTM1 TRAF1 PIK3R2 PIK3R1 NFATC1 MTOR MAP2K2;MAP2K1 NFKB2 NFKBIA MAPK1 AKT1 TAB2 TAB1 FHL2 MAP2K6 MAPK3 GAB2 TNFRSF11B TRAF2 SYK FOS RAC1 AKT2 TRAF3 TRAF6 PTK2 SRC RELA MAPK9 JUN SPI1 PLCG1 MAPK14 TRAF5 IKBKB IKBKG MAP3K7 TNFSF11 CHUK TNFRSF11A MAPK8 LYN MAP2K7 CBL NFKB1 MITF RELB STAT1 CDC42 PAPSS2 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260810%WP4628%HOMO SAPIENS Aerobic glycolysis augmented ALDOA PKM GPI TPI1 PGAM2 SLC2A1 GPT GAPDH-1 HK1 LDHA PFKM PGK1 ENO1 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP75%HOMO SAPIENS Toll like receptor signaling CCL3L1;CCL3L3;CCL3;CCL18 MAP2K3 IFNAR1 LY96 IRAK1 RIPK1 FADD CD14 MAP2K2;MAP2K1 NFKBIA CXCL10 CXCL11 MAPK1 TOLLIP AKT1 TAB3 TAB2 TAB1 MYD88 CXCL9 MAP2K6 CD40 MAPK3 CXCL8 CASP8 TNF LBP FOS RAC1 IRAK4 TIRAP TLR1 AKT2 IRF3 AKT3 TRAF3 IL1B TRAF6 TLR9 IRF7 NFKBIB TLR8 TLR7 IRF5 TLR6 TLR5 TLR4 TLR3 TLR2 RELA MAPK9 JUN CCL4L2;CCL4L1;CCL4 CCL5 MAPK14 SPP1 IFNB1-4 MAPK12 MAPK13 MAPK10 MAPK11 IKBKB IKBKG IKBKE MAP3K7 MAP2K4 CHUK MAPK8 MAP2K7 NFKB1 IL6 CD86 CD80 TBK1 IL12B MAP3K8 IL12A IFNAR2 STAT1 TICAM2 TICAM1 TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260810%WP3851%HOMO SAPIENS TLR4 signaling and tolerance IFNB1-4 IRAK1 RIPK1 IKBKB IKBKG NFKBIA IKBKE MAP3K7 TAB2 CHUK TAB1 MYD88 CXCL8 TNF IRAK3 NFKB1 IRAK4 TIRAP IL6 IRF3 TRAF3 TRAM1 TRAF6 TBK1 IRF7 TLR4 INPP5D TICAM1 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260810%WP5130%HOMO SAPIENS Th17 cell differentiation pathway CRY1 SOCS3 STAT5A NFATC1 MTOR IL2RA NFKBIA MAPK1 IRF4 IL27 JAK2 TYK2 ARNTL RXRA FOS RARA CLOCK IL27RA IL23R CD3G CD3E IL1B CD3D ZAP70 IL23A IL21 LCK IL17A IL22 IFNGR1 JUN HIF1A PLCG1 MAPK14 CD4 PRKCQ CD247 TGFBR1-1 NR1D1 IL17F LAT IKBKB PPP3CA HSP90AA1 RORA IL6R MAPK8 TGFB1 RUNX1 NFIL3 FOXP3 IFNG NFKB1 HLA-DMA IL6 SMAD2;SMAD3 TBX21 IL21R GATA3 RORC AHR STAT6 JAK1 IL4R STAT1 STAT3 PER1 IL2 IL4 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation SFN ZP1 ZP2 MDH2 PTPMT1 LMNA G3BP1 SRRM3 HSPB1 RAF1 YWHAG TMEM120B DAPK2 RHBDD2 TMEM120A SSC4D POR ZP3;POMZP3 STYXL1 KIF1C PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260810%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3R4 PIK3CD PIK3R5 PIK3R3 PIK3R2 PIK3CB PIK3R1 PIK3C2G PIK3CA PIK3C2A PIK3C2B PIK3R6 PIK3CG CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260810%WP2029%HOMO SAPIENS Cell differentiation index HDAC5 TLX3 TLX1 STAT3 TLX2 LEFTY2;LEFTY1 SRF SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260810%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis TBX6 NOTCH1 HES7 LFNG MESP2 EPHA4 DLL1 RIPPLY2 DLL3 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260810%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling TOR1AIP1 SPP1 SREBF1 APC TCF7 DICER1 GSK3B SLC2A4 CEBPA WNT10B CEBPB CEBPD AGO2 CCND1 TLE1 ICMT CSNK1A1 ZMPSTE24 AXIN1 FNTA TARBP2 LMNA LEF1 CDK6 PPARG HES1 HES5 TCF7L2 HMGA2 EMD ADIPOQ CTNNB1 RUNX2 TCF7L1 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260810%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids CHKB ETNK2 PCYT1A PISD PCYT1B PTDSS2 PTDSS1 CEPT1 ETNK1 PEMT CHPT1 SGPL1 CHKA PCYT2 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260810%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT6 PRMT8 PRMT7 PRMT3 DDAH2 DDAH1 PRMT1 CARM1 NOS1 PRMT5 PRMT2 NOS2 NOS3 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260810%WP536%HOMO SAPIENS Calcium regulation in cardiac cells CACNA1E GNG13 GNB3 GNGT1 YWHAE RYR2 CHRM4 CHRM5 RGS16 YWHAG CHRM1 YWHAH SFN ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 CAMK1 ADCY6 ADCY5 ADRA1B ADRA1A GNB2 PLCB3 GNB1 CAMK4 ADCY9 GNAQ GNB4 ITPR1 PKIA GNG2 GNG5 GNG4 GNG8 RYR3 RGS10 CAMK2B GJA1 CAMK2G GJA3 GJA5 GJB2 GJA8 CALM3;CALM1 ORAI1 CALM2 CALR-1 ITPR2 CACNA1D RYR1 CACNA1B RGS2 CACNA1A ITPR3 CACNA1C KCNJ5 PRKCG PRKCB CACNA1S GJA4 GJA9 ATP2A3 ATP1B2 STIM2 GJC1 GJC2 GJB4 GNAZ GJB3 GJB5 ARRB1 ARRB2 GJD2 YWHAB CASQ2 CASQ1 ATP1A4 YWHAQ KCNB1 ATP1B3-1 PRKACA-1 SLC8A3 GRK6 CAMK2A GNA11 ADRB1 ADRB2 CHRM3 PRKACB-1 PRKCD ADRA1D YWHAZ FKBP1A ATP1B1 GNAO1 PRKAR1A GNAI3 GNAI1 PRKCA GNAI2 RGS14 FXYD2;FXYD6-FXYD2 PRKCH PRKCE PRKCQ RGS4 RGS5 RGS3 RGS1 PRKCZ GJB6 RGS9 RGS6 RGS7 CACNB1 CACNB3 ANXA6 CHRM2 GRK5 GRK4 PKIB PKIG RGS18 RGS17 PRKD1 KCNJ3 CAMK2D RGS19 SLC8A1 RGS20 ATP2B3 ATP2B2 RGS11 ATP2B1 PRKAR1B CALM1 GNAS-1 ATP2A2 PRKAR2B PRKAR2A GJB1 ADRB3 GNB5 DOPAMINE METABOLISM%WIKIPATHWAYS_20260810%WP2436%HOMO SAPIENS Dopamine metabolism COMT TYR PRKACA-1 TH DDC NQO1 MAOB PPP2CB;PPP2CA PRKACB-1 MAOA SOD1 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260810%WP5234%HOMO SAPIENS Bardet Biedl syndrome PKD1 CLUAP1 CFAP410 MAK CNGA1 PKHD1 GLI2 NEK8 MKS1 CNGB1 CRX DCDC2 C8orf37 SCAPER EFHC2 GLI3 PKD2 INVS FLCN NPHP3 IQCB1 ARNTL KIF7 RP2 EFHC1 CEP164 RAB23 BBS4 PKD1L1 IFT172 PDE6D SMO PCARE ZIC2 LCA5 LZTFL1 WDPCP CEP104 ARL6 CEP41 ARL3 TRIM32 CEP290 TTC21B INPP5E GPR161 BBS2 BBS1 FUZ OCRL IFT52 TMEM107 DYNC2H1 DYNC2I2 DYNC2I1 TRAF3IP1 BBS9 BBS7 IFT57 BBS5 IFT140 MKKS DYNLT2B WDR19 BBS10 IFT122 IFT80 EVC WDR35 BBS12 PTCH1 TMEM216 CILK1 DYNC2LI1 IFT43 IFT74 IFT81 ARL13B BBIP1 TMEM67 IFT27 EVC2 NEK1 SCLT1 USP9X TTC8 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260810%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins CTH RPL30 SELENBP1 SP1 TXNRD1 SP3 NFE2L2 SELENOK SELENOP SELENOI SEPHS1 SEPHS2 PSTK EEFSEC SECISBP2 DIO1 DIO3 TRNAU1AP SELENOO SEPSECS FOS NFKB1 SELENON TXNRD3 SARS1 SARS2 SELENOS SCLY GPX1 SELENOT GPX4 CREM GPX6 POU2F1 TXNRD2 RELA FABP1 JUN METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260810%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders MAT2B CTH BHMT CDO1 CSAD MAT1A AHCY CBS;CBSL ADK MTR-1 GNMT PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260810%WP2253%HOMO SAPIENS Pilocytic astrocytoma PTPN11 KRAS GRB2 RAF1 SOS1 NF1 HRAS NRAS BRAF DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260810%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport SLC27A5 SLC51A SLC51B SLC10A2 ABCB11 ABCC3 SLC10A1 HSD17B4 ABCB4 CYP7B1 CYP7A1 ACOX2 ABCD3 ABCB1 CYP27A1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 ABCC4 HSD3B7 FABP6 BAAT ATP8B1 SCP2 CYP8B1 AKR1D1 AMACR SLC27A2 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260810%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 GSDMD CGAS IFNB1-4 NFKB1 NFKBIE NLRX1 IRF3 IKBKB IL1B STING1 NFKBIA IKBKG NLRP3 IKBKE F3 TBK1 CHUK ITPR1 REL RELA SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260810%WP15%HOMO SAPIENS Selenium micronutrient network HBA2;HBA1 PTGS2-2 CTH MTR-1 TXNRD1 NFKB2 MTHFR SELENOP SELENOI CAT SEPHS2 ALOX5 TNF ICAM1 DIO1 PNPO DIO3 SELENOO SELENON CRP TXNRD3 FGB FGA SELENOS SELENOT IL1B SERPINA3 FGG ALB SERPINE1 PLAT SAA2;SAA1 TXN SAA2-SAA4;SAA4 PLG PRDX3 CCL13;CCL2 PRDX5 F7 PRDX4 PTGS1 ABCA1 SCARB1 RELA F2 APOA1 APOB LDLR INS;INS-IGF2 FLAD1 RFK ALOX15B SELENOK ALOX5AP GGT1 SOD2 XDH GSR IFNG NFKB1 CBS;CBSL IL6 PRDX2 GPX1 GPX4 GPX6 PRDX1 MPO KMO KYNU INSR TXNRD2 SOD3 HBD;HBB SOD1 PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260810%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR HEROIN METABOLISM%WIKIPATHWAYS_20260810%WP2645%HOMO SAPIENS Heroin metabolism BCHE CES2 CES1 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260810%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260810%WP5360%HOMO SAPIENS KCNQ2 related epilepsies AKAP5 CSNK2A1;CSNK2A3 KCNQ2 KCNQ3 CALM1 PRKCA PPP3CC BDKRB2 BACE1 STX1A PPP1R10 ANK3 AGTR1 CHRM1 PRKACA-1 P2RY1 SCN1B ITPR1 PLCG2 MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260810%WP4318%HOMO SAPIENS Mitochondrial fission and fusion PLD1 OPA1 BNIP3 MFN1 MFN2 SH3GL2 BAX DNM1L BCL2L1 MTFP1 FIS1 MIB1 PHB STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis CYP21A2 SRD5A2 CYP17A1 SRD5A1 HSD3B1;HSD3B2 AKR1D1 CYP11A1 SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260810%WP4496%HOMO SAPIENS Signal transduction through IL1R MAPK14 IL1RAP MAP2K3 IFNB1-4 IRAK1 IRAK2 TGFB2 IKBKB NFKBIA MAP3K7 IL1RN TOLLIP CHUK TAB1 MYD88 MAP2K6 TGFB3 MAPK8 TNF TGFB1 MAP3K1 ECSIT IRAK3 NFKB1 IL6 MAP3K14 IL1B TRAF6 IL1A IL1R1 RELA JUN INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260810%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy SLC16A1 PDHA1 PPARGC1A MTOR PKM MAP2K2;MAP2K1 BRAF PKLR DLD GLS MAPK1 ACSS1 RAF1 RPTOR RPS6KA2 MAPK3 RPS6KA1 G6PD LDHB GSR MLST8 PFKFB2 TRAP1 GPX4 NAMPT MITF PGLS SLC2A1 SLC1A5 SLC16A3 ARAF RPS6KA3 LDHA DLAT CPT1A 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome CCDC42 APC RAC1 RHOA STAT3 AMER3 PLEKHB2 MZT2A;MZT2B STMN2 FAM168B ARHGEF4 CDC27 GPR148 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260810%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis MED15 HMGCS1-1 SCD PRKAA1 NR1H3 SREBF1 PPARGC1A SREBF2 SIRT6 SIRT1 MTOR LDLR FASN HMGCR PPARA ABCA1 AXON GUIDANCE%WIKIPATHWAYS_20260810%WP5289%HOMO SAPIENS Axon guidance FES ITGB1 MET MAPK1 RAF1 HRAS DCC ABL1 BOC RAC1 ROCK1 PARD6A DPYSL2 ARHGEF12 TRPC1 GNAI1 CDK5 PRKCA CFL1 RGMA EFNA1 EPHB1 RHOD SRC NGEF NTN4 NTN3 FYN ROBO1 SEMA5B ROBO3 ROBO2 DPYSL5 SEMA6C UNC5D ENAH ILK SEMA7A EFNB1 GSK3B SEMA3A ABLIM3 PRKCZ SLIT1 NCK1 SLIT3 SLIT2 LRIG2 LRRC4C SRGAP2 NTNG2 WNT4 L1CAM SHH GDF7 CXCL12 FZD3 PDPK1 PLXNA1 RYK-1 PARD3 WNT5A NRP1 MYL12B CXCR4 PTCH1 EPHA2 BMPR2 CDC42 BMPR1B RRAS RASA1 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260810%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission PLCG1 PIK3R3 PIK3R2 PIK3CB PIK3R1 GABRB3 PTEN GABRB2 PIK3CA GABRB1 AP2A1 AP2A2 GABRG3;GABRG2 GABRE JAK2 GABRD GABRQ SHC1-1 GABRA2 GABRA1 GABRP PIK3CG GABRA6 GABRA5 GABRA4 CREB1 GABRA3 ROCK1 AP2B1 GABRG1 CREM NTRK2 RHOA SLC12A5 NGFR STAT3 BDNF EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260810%WP3930%HOMO SAPIENS EDA signaling in hair follicle development DKK4 GLI1 DKK1 SOSTDC1 PTCH1 WNT3 SHH EDARADD LTB RELB EDA EDAR BMP1 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway MAPK14 ATF2 SPAG1 CRK BCAR1 PXN MAPK11 BCLAF1 PIK3R1 BRAF PIK3CA BCL2 HSPB1 GRB2 KRAS MAPK1 DOK1 AKT1 RAF1 HRAS MAPK3 SHC1-1 RPS6KA1 MEF2C EIF4B ABL1 GAB2 BCR MAP3K2 CBL SOS1 AKT2 NRAS AKT3 SHC4 SHC2 SHC3 PTK2 SRC BCL9 HSPB2 ARAF CRKL INPP5D VAV1 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260810%WP2855%HOMO SAPIENS Dopaminergic neurogenesis GLI1 NKX6-1 CDKN1C RET FOXA2 GLI2 SHH NEUROG2 FGF8 GBX2 MSX1 PITX3 WNT1 EN2 LMX1A TH EN1 ALDH1A1 SOX2 LMX1B NR4A2 SLC6A3 TGFB1 DDC ASCL1 SLC18A2 NEUROD1 OTX2 STAT3 NKX2-2 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260810%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development EIF2AK3 CSNK2B CSNK2A1;CSNK2A3 KCNQ2 ATF4 SEMA3A DDIT3 SNAP25 ATF6 L1CAM SPTAN1 DNM1L SCN5A ANK3 SPTBN4 BRSK1 BRSK2 MAPT PRRT2 ANK2 CSNK2A2 PRICKLE1 SCN2A EIF2A ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260810%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis PTGS2-2 TRPA1 CACNA1H KCNQ2 TRPV1 KCNQ3 PTGS1 FAAH HTR1A INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260810%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells RRAS2 NRAS MRAS RAB5B BRAF RAB5C KRAS MAPK1 HGS RAF1 ARAF HNRNPH1 RRAS HRAS MAPK3 PDCD6IP RAB27A RAB5A CORI CYCLE%WIKIPATHWAYS_20260810%WP1946%HOMO SAPIENS Cori cycle ALDOA SLC2A4 GPI TPI1 INS;INS-IGF2 TALDO1 PGAM1 SLC2A1 GPT GAPDH-1 PFKP HK1 LDHA G6PD SLC2A2 PGK1 CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260810%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer CDKN1B PIK3CD PIK3R5 PIK3R3 PIK3R2 PIK3CB PIK3R1 MTOR INS;INS-IGF2 PIK3C2G PIK3CA PIK3C2A PIK3C2B ESR1 KRAS CDKN1A MAPK1 AKT1 RAF1 PIK3R6 RPTOR CCNE1 EGFR HRAS MAPK3 IRS1 CCND1 PIK3CG ERBB2 PIK3R4 CDK6 AKT2 NRAS AKT3 CDK4 CDK2 CYP19A1 IGF1R WNT SIGNALING%WIKIPATHWAYS_20260810%WP428%HOMO SAPIENS Wnt signaling FZD5 FZD8 CCND3 CCND2 ROCK2 SOX17 INVS ROR1 VANGL2 PPP3CC RHOA PLCB3 PLCB4 FRAT2 PLCB1 PLCB2 CSNK2A2 DAAM1 DKK2 TCF7L1 DKK4 SFRP4 CSNK2B WNT2B NOTUM PORCN WNT1 WNT2 CXXC4 WNT3A CCND1 WNT7B CER1 SFRP5 WNT5A SOST CAMK2B CSNK1A1 DKK1 KREMEN1 SERPINF1 CAMK2G CHD8 SENP2 SFRP2 CTNNB1 MYC PRKCG PRKCB NFATC3 NFATC1 NFATC4 CAMK2A CSNK2A1;CSNK2A3 RAC1 PRKCA SFRP1 FZD10 PLAU JUN MAPK9 WNT5B WIF1 APC CTBP2 TCF7 GSK3B WNT6 DVL1 DVL2 DVL3 PPP3CA WNT3 WNT4 FZD1 MAP3K7 WNT10B PPP3R1 WNT10A FZD3 PPP3CB FZD2 FZD7 FZD6 FZD9 FOSL1 CAMK2D TPTEP2-CSNK1E;CSNK1E PRICKLE1 MAPK8 RYK-1 CTNNBIP1 DAAM2 VANGL1 AXIN1 PRICKLE2 GPC4 NFATC2 WNT16 ROR2 LEF1 LRP5 CTBP1 NKD1 LRP6 NKD2 WNT11 NLK TCF7L2 WNT7A BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260810%WP5606%HOMO SAPIENS Beta globin gene expression regulation KLF1 LDB1 HDAC2 CHD3 PPARGC1A NR2C1 GATAD2B TAL1 MTA2 HDAC1 ZFPM1 ZBTB7A BCL11A MYB LMO2 DNMT1 KDM1A HBG2;HBG1 NR2C2 HBD;HBB GATA1 BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation FOXO1-1 DKK1 SMAD1 SMAD9 SMAD5 DCN WNT4 BMP2 SFRP1 CTNNB1 SST BCL2L11 LEFTY2;LEFTY1 CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP3869%HOMO SAPIENS Cannabinoid receptor signaling MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 MAPK1 CYP2C9;CYP2C19 PRKACA-1 MAPK3 MAPK8 FAAH PRKACB-1 ADCY1 CNR1 PRKAR1B ADCY7 ADORA2A PRKAR1A DAGLA NAPEPLD DAGLB AHR PRKAR2B CYP1A1 CNR2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MAPK9 CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation GLRA2 GLRA3 GLRB FEV FABP7 RIMBP2 OLIG2 SNAI2 SNAP25 GLUL CNP ITGB1 DLL1 LHX1 MSX1 MOG SLC1A2 DLG4 SOX17 ADRA2C ADRA2B ADRA2A NR4A2 TPM1 PAX3 DCX PAX6 HES1 CLDN11 HES5 CACNG2 NLGN1 CASK GRIN1 HNF4A HTR5A NOTCH1 FGF4 FOXA2 AP2A1 SLC6A1 AP2A2 GPHN SLC6A5 LMX1B MIXL1 SLC6A9 GABBR2 ACHE GABBR1 SLC6A2 SLC6A3 TNC GAD1 BMP4 GAD2 NODAL PECAM1 SLC18A3 UNC13A SYP KLF4 SLC6A4 NGFR DLG2 SLC17A6 TUBB3;TUBB6 SLC17A7 CSPG4 HOMER2 ITGA6 GLS ZFP42 GATA4 NEFM SHANK3 HES3 SHANK1 TBXT GRIN2B ERAS ALDH1L1 CD34 NEFL ROBO1 POU5F1;POU5F1B HOMER1 HOMER3 AQP4 ESRRB TH NANOG;NANOGP8 KCNJ6 SOX2 FOXD3 TPH1 LEF1 SOX9 CHAT GATA6 SLC1A3 RIMS2 MSX2 PPFIA1 BSN SOX10 RBFOX3 MAP2 FBXO15 TBR1 KRT15 TWIST2 LIN7A FUT4 MBP EVX1 DLG1 GFAP DLG3 CD24 NES CDH2 PCLO CDH1 ERC1 HTR1A DPPA3 SNAI1 DPPA2 GLRA1 TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260810%WP619%HOMO SAPIENS Type II interferon signaling SPI1 TAP1 PTPN11 CYBB SOCS3 IFIT2 IFNB1-4 GBP2;GBP3;GBP1 OAS1 IRF9 CXCL10 EIF2AK2 IRF8 NOS2 IRF4 CXCL9 JAK2 PRKCD HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E ICAM1 PSMB9 IFNG IRF2 ISG15 IRF1 IL1B STAT2 SOCS1 JAK1 CIITA STAT1 REG1B;REG1A IFNGR1 IFNGR2 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260810%WP661%HOMO SAPIENS Glucose homeostasis INS;INS-IGF2 HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260810%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling ZBTB16 PIK3CD KSR1 TSC2 TSC1 PIK3CB MTOR MAP2K2;MAP2K1 BRAF FGFR1 PIK3CA TELO2 FLT1 NFKBIA GRB2 KRAS CDKN1A MET MAPK1 AKT1 RAF1 RPTOR RHEB JAK2 HRAS PPARD MDM2-2 MAPK3 SHC1-1 PDGFRB PDGFRA DEPTOR NTRK1 PIK3CG MLST8 FOXO1-1 TEK TTI1 KDR PML FOS SOS1 RARA SOS2 AKT2 AKT3 ELK1 NTRK2 TP53 PTK2 SRC RETN RELA JUN AKT1S1 GAREM2 ULK2 CSF1R APC NFKBIE GSK3B SALL4 IKBKB PTEN IKBKG WNT1 CHUK FZD6 IL6R EGFR CCND1 RUNX1T1 CSNK1A1 AXIN2 NFKB1 IL6 LEF1 LRP5 KIT FGFR2 LRP6 PYGO1 EPHA2 BCL9 CTNNB1 NGFR IGF1R INSR STAT3 FGFR4 MYC FGFR3 REL FLT3 FLT4 JUP EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260810%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria RBBP4 RB1 SREBF1 HDAC2 CHD3 MBD2 CBX1 LEF1 MTA2 MTA3 HDAC1 CHD4 RBBP7 TP53 CBX5 SUV39H1 MTA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KDM1A INPP5K MBD3 E2F1 H3-3A CBX3-1 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260810%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates FOXO1-1 HIF1A VEGFA KDR U2AF2 OTUB2 USP37 USP44 MTOR VHL OTUD7B USP28 PIK3CA OTUD6B PGAM1 SLC2A1 AKT1 FBP1 USP7 HK2 LDHA MYC PGK1 G6PC1 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260810%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA SCP2 ACAA1-1 HSD17B4 ACOX1 LEPTIN SIGNALING%WIKIPATHWAYS_20260810%WP2034%HOMO SAPIENS Leptin signaling ACACA PRKAA1 SOCS3 STAT5B PIK3R2 PIK3R1 LEPR MTOR MAP2K2;MAP2K1 SOCS7 KHDRBS1 EIF4EBP1 KPNA4-1 GRB2 ROCK2 MAPK1 AKT1 RAF1 EIF4E JAK2 HRAS MAPK3 SHC1-1 IRS1 RPS6KA1 RPS6 FOXO1-1 RPS6KB1 CREB1 SOS1 RAC1 ROCK1 PDE3B CFL2 PRKAA2 ELK1 BAD RHOA PTK2 SRC FYN RELA PLCG2 NCOA1 PLCG1 GSK3A ACACB PTPN11 MAPK14 GSK3B IKBKB PTEN SP1 IKBKG ESR1 CHUK NOS3 MAPK8 ERBB2 PTPN1 NFKB1 SH2B1 SOCS2 JAK1 STAT1 LEP CDC42 STAT3 CISH REL IL26 SIGNALING%WIKIPATHWAYS_20260810%WP5347%HOMO SAPIENS IL26 signaling MAPK14 SOCS3 CCL20 DDIT3 IL33 CTSK NFATC1 PIK3CA NFKBIA EPHA3 MAPK1 AKT1 TNFSF11 IL26 JAK2 MAPK3 CXCL8 IL10RB MAPK8 TYK2 TNF MMP9 ICAM1 DEFB4A;DEFB4B CASP3 ATP6V0D2 IL6 SMAD2;SMAD3 IL10 IL20RA IL1B MPO RORC DCSTAMP BAX CSF2 JAK1 STAT1 IL17A MMP1 STAT3 ACTA2 RELA MAPK9 JUN 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome ZP2 COL2A1 CIAO2A ANKRD39 LMAN2L MAPK1 NCAPH PARL CIAO1 FAM178B ITPRIPL1 TMEM127 ADRA2B CNNM3 MAPK3 CNNM4 FER1L5 STARD7 ERBB2 SEMA4C ASTL NEURL3 KANSL3 PLXNB2 MMS19 SNRNP200 CIAO2B ANKRD23 COX11 DUSP2 RHOA MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260810%WP4315%HOMO SAPIENS Malate aspartate shuttle MDH1 SLC25A11 SLC1A3 GOT2-1 VISUAL CYCLE%WIKIPATHWAYS_20260810%WP5534%HOMO SAPIENS Visual cycle RDH12 RDH8 OPN1SW ABCA4 LRAT RLBP1 RBP3 RDH11 RBP1 RHO RDH5 RDH10 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW RPE65 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260810%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells MCU TGFBR1-1 CASP9 MTOR TRPV5 BRAF PIK3CA PPP3R1 MAPK1 BAK1 AKT1 TNFSF11 CALCA RAF1 MAP3K5 TNFRSF1A APAF1 SMAD4 PTH CASP8 TGFB1 CASP3 FFAR3;GPR42 SMAD2;SMAD3 CRYZL2P-SEC16B;SEC16B RGN G3BP1 NOS1 BAX PDE1B ACTA2 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260810%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma FZD5 FZD8 CCND3 CCND2 SOX17 ROR1 CSNK2A1;CSNK2A3 MTDH SFRP1 FRAT2 SOX7 FZD10 PLAU CSNK2A2 ELAVL1 DKK2 JUN TCF7L1 WNT5B DKK4 WIF1 SFRP4 CSNK2B WNT2B APC CTBP2 TCF7 GSK3B WNT6 DVL1 DVL2 DVL3 WNT3 NOTUM WNT4 FZD1 WNT10B PORCN WNT10A FZD3 EZH2 FZD2 WNT1 FZD7 CXXC4 WNT2 FZD6 FZD9 FOSL1 WNT3A CCND1 WNT7B CER1 TPTEP2-CSNK1E;CSNK1E RYK-1 SFRP5 WNT5A CTNNBIP1 SOST CSNK1A1 AXIN1 KREMEN1 DKK1 SERPINF1 WNT16 CHD8 ROR2 SENP2 LEF1 SFRP2 LRP5 CTBP1 NKD1 LRP6 NKD2 WNT11 NLK TCF7L2 WNT7A KLF4 CTNNB1 MYC TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260810%WP465%HOMO SAPIENS Tryptophan metabolism ACAT1 ECHS1 MAOA ASMT ALDH2 DLD HADH AANAT CAT INMT AOX1 TPH1 DDC AOC1 KYAT3 AADAT KYAT1 TPH2 GOT2-1 HAAO ALDH8A1 AHR IL4I1 KMO ACMSD TDO2 KYNU STAT1 AFMID IDO2 IDO1 CYP1A1 GCDH PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260810%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases DPYS NT5C TYMP OTC TK2 NT5C3A CAD RRM1 UPB1 TYMS DHODH GLS2 ABAT ALDH6A1 DPYD UMPS RRM2-1 RRM2B AGXT2 CPS1 NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260810%WP3645%HOMO SAPIENS NAD biosynthetic pathways SIRT4 SIRT5 SIRT6 SIRT1 BST1 SIRT2 SIRT3 NADSYN1 NMNAT1 NAMPT PARP4 PARP2 CD38 QPRT TNKS2 NAPRT ACMSD TDO2 IDO1 TNKS PARP1 SICKLE CELL DISEASE%WIKIPATHWAYS_20260810%WP5604%HOMO SAPIENS Sickle cell disease HBA2;HBA1 IL18 TLR4 IL1B HBD;HBB HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260810%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 GLI1 CCND2 GJB6 PDGFA FGF1 ITGB1 GLI2 SHH FZD1 EDA CCND1 TP63 NCAM1 PDGFRA WNT5A LAMA5 INHBA NFKB1 BMP4 LEF1 LRP5 FGFR2 PTCH1 GTPBP4 FOXI3 CTNNB1 RUNX2 SMO CDH1 MYC EDAR SNAI1 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260810%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IRF7 TLR8 TLR7 MR1 IFIH1 TNFRSF11A TLR3 IRF3 DDX58 MAVS NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260810%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence PRKAA1 MDH1 MDH2 SIRT5 SLC2A4 IL6 NMNAT2 SIRT1 SIRT2 SIRT3 IL1B GOT1-1 GOT2-1 NAMPT TP53 SLC2A1 G6PD PARP1 ELAVL1 RELA CCL27 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260810%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ACOT2;ACOT1 FADS1 ELOVL3 SCD ACSL3 ELOVL2 FASN ACSL4 ELOVL1 SCD5 ELOVL5 ELOVL6 FADS2 ACSL1 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260810%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer RB1 CDKN1B POLE CCND3 E2F3 RRM1 HDAC1 SIN3A CHEK1 DCK RBBP7 TYMS SMC1A PLK4 CDKN1A CDC25A CCNE2 RRM2-1 RAF1 PRMT2 DHFR2;DHFR CCNE1 BARD1 HMGB2 PRKDC MDM2-2 CCNB2 PCNA E2F1 ABL1 PRIM1 RBBP4 MCM7 POLD3 SKP2 RPA2 ORC1 RFC5 RFC3 CDT1 CDK6 RFC4 CDC7 STMN1 MCM3 CDK4 RPA1 CDK2 MSH6 MCM6 CDK1 RBP1 RPA3 TP53 TOP2A POLA1 CDC45 SMC2 POLE2 KIF4B;KIF4A TTK DNMT1 NPAT CDC25B HLTF ANLN RABIF CCNA2-1 H2AZ2;H2AZ1 MCM4 ZNF655 TFDP1 MAPK13 TFDP2 E2F2 SUV39H1 WEE1 CCND1 CCDC6 SAP30 FANCG FAF1 CCNB1 HMGB1-1 SMC3 SMARCA2 MYC RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260810%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex POLR2F TBP TAF12 TAF13 POLR2C ERCC3 TAF7 TAF6 TAF5 NELFA NELFE THRA POLR2A POLR2B POLR2D POLR2E POLR2G POLR2H NELFB POLR2I POLR2L MED23 TAF8 ELK1 MED27 TAF2 POLR2J;POLR2J2;POLR2J3 MED19 MED16 MED18 MED15 MED17 MED12 MED11 MED14 MED13 MED10 MED8 MED4 GTF2F1 MED26 MED6 MED29 MED9 MED7 MED22 MED25 MED24 MED21 MED20 GTF2A1 CCNC-1 MED28-1 CTDP1 MED30 POLR2M TAF10 TAF11 MED31-1 TAF4 TAF3 TAF1 CDK8 MED1 GTF2B TAF9 NELFCD GTF2E2 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260810%WP5195%HOMO SAPIENS Disorders in ketolysis BDH1 HMGCS1-1 OXCT1-1 ACAT1 ACAT2 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260810%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity AXL ITGB3 ITGAV PARD6A CAP1 MARK2 ATP8B2 MARK1 CX3CR1 XIAP ATP10A CASP9 CASP7 ATP11A BAK1 TGFB3 PATJ PARD3 C4BPB ATP11C PLSCR1 LLGL2 MARK3 ATP8B3 VTN DLGAP5 PLSCR3 IFNG PLSCR4 CR1L;CR1 CRB2 COLEC12 CRB1 COLEC10 PARD6G SUSD4 CSMD1 DEDD DIABLO-1 ITGAM ITGB2 ITGAX CFD C5 C1QB C1S CFB TGFB2 C1R C8B CFP C8A TYRO3 C2 C6 C8G C7 C9 MASP2 MASP1 COLEC11 CD55 FCN2;FCN1 FASLG C1QC CASP10 APAF1 GAS6 MFGE8 CASP8 MERTK C4BPA CASP3 C3-1 CX3CL1 CYCS-1 MBL2-1 CD59 BID FAS BAX SERPING1 PROS1 PRKCI CLU MPP5 C3AR1 CR2 C5AR2 CFI C5AR1 PRKCZ CFH-3 SCRIB LOC110384692;C4A;C4B_2;C4B PARD6B TGFB1 HTRA2 ATP8B1 MBP OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260810%WP623%HOMO SAPIENS Oxidative phosphorylation ATP6AP1 ATP5MC2 ATP5MC3 ATP5MC1 NDUFA11 ATP5F1A NDUFA10 ATP5F1B ATP5MG ATP5ME DMAC2L ATP5PF ATP5PD ATP5PB NDUFC2;NDUFC2-KCTD14 ATP5F1D NDUFV3 ATP5PO NDUFV2 NDUFS5-1 NDUFC1 NDUFS7 NDUFS6 NDUFS4 NDUFS2 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFA4L2 NDUFB1 NDUFA8 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFAB1 NDUFS8 NDUFS3 NDUFV1 NDUFB10 NDUFA9 NDUFA4 GZMH;GZMB-1 ATP6AP2 CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260810%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling CYP11B1;CYP11B2 TCF4 PRKCB CYP21A2 CACNA1H ACACA GNB3 ERN1 NR4A1 MAP2K2;MAP2K1 BRAF ECE1 NFKBIA GNAZ BCL2 ARRB1 CRH ARRB2 CRHR1 CRHR2 MAPK1 AKT1 RAF1 TRIM28 MAP3K5 GRK6 CAMK2A GNA11 MAPK3 CXCL8 PRKCD NR4A2 GNAO1 CASP3 CREB1 FOS RAPGEF3 GNAI1 PRKCA PRKAA2 GNAI2 ELK1 RHOA RAP1B PTK2 GNB2 GNB1 GNAQ TLR4 PRKCI SULT2A1-4 RELA PLCG2 MAPK9 PLCG1 MAPK14 FOSL2 JUNB PRKCQ JUND GSK3B CASP9 KRT16;KRT14 SP1 HSP90AA1 NCOA2 NOS3 IL18 POMC FOSL1 MAPK8 PARP1 TGFB1 GJA1 NFKB1 FOSB GNAS-1 CRHBP KRT1 IVL GRK3 TBX19 CTNNB1 IL2 TFAP2A HSD3B1;HSD3B2 GNB5 STAR CYP11A1 JUP MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260810%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFB7 NDUFB6 NDUFA13 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA8 NDUFA7 NDUFA6 NUBPL NDUFA5 NDUFA3 NDUFAB1 NDUFS3 NDUFAF2 ECSIT ACAD9 NDUFA12 NDUFV1 NDUFAF1 NDUFA10 NDUFB10 NDUFB11 NDUFC2;NDUFC2-KCTD14 NDUFV3 NDUFV2 NDUFAF7 NDUFS5-1 DMAC2 FOXRED1 TMEM186 TIMMDC1 NDUFC1 TMEM70 NDUFAF6 NDUFS6 NDUFAF4 NDUFS4 NDUFS2 NDUFAF3 NDUFS1 TMEM126B NDUFB9 NDUFB8 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260810%WP5029%HOMO SAPIENS Amino acid transport defects IEMs CLTRN SLC36A2 SLC1A1 SLC7A9 SLC6A20 SLC6A19 SLC3A1 SLC7A7 SLC3A2 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260810%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis COL1A1 BCAR1 EDNRA YAP1-1 SNAI2 TEAD1 TEAD2 TEAD3 TEAD4 PBX3 FN1 THBS2 SPARC COL3A1 COL5A1 GPC6 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260810%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups NAGS SARDH ALDH18A1 OTC GLUD1;GLUD2 CKB ODC1 ACY1;ABHD14A-ACY1 GAMT SRM ARG2 OAT SMS ARG1 GATM PYCR1 ASS1 PYCR3 CPS1 CKM ASL PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260810%WP134%HOMO SAPIENS Pentose phosphate metabolism TALDO1 PGLS RPIA PGD G6PD TKT RPE;RPEL1 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP4784%HOMO SAPIENS Proteoglycan biosynthesis SLC35B3 CSGALNACT1 SLC35B2 B3GALT6 CANT1 B3GAT3 XYLT2 XYLT1 CHSY1-1 BPNT2-1 EXTL3 SLC26A2 EXT1 B4GALT7 EXT2 PAPSS2 CHST3 CHST14 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260810%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult HBA2;HBA1 LDB1 TAL1 LMO2 HBG2;HBG1 HBZ HBD;HBB GATA1 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260810%WP694%HOMO SAPIENS Arylamine metabolism SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYP1A2 JOUBERT SYNDROME%WIKIPATHWAYS_20260810%WP4656%HOMO SAPIENS Joubert syndrome MRE11 TMEM138 ATF4 ANKS6 RAB8A CETN1 AHI1 CCP110 ARR3 MTOR ARL2 MYO6 NPHP1 PCNT RAB3IP NIN NEK8 MKS1 RHEB TMEM237 UNC119 INVS NPHP3 ZNF423 RP2 RAD50 CEP164 BBS4 RHOA ATM PDE6D CEP120 PDE6B PDE6A CEP97 ARMC9 RPGRIP1L KIAA0586 CEP104 CEP41 ARL3 OFD1-1 B9D2 CEP290 DVL1 INPP5E DVL3 PIBF1 SHH BBS2 BBS1 CPLANE1 TMEM231 TMEM17 PARP1 TCTN3 TCTN2 KAT5 TCTN1 BBS9 BBS7 CC2D2A BBS5 TMEM216 CETN2 ARL13B TMEM67 CSPP1 FLNA TTC8 B9D1 MYO5A OVARIAN INFERTILITY%WIKIPATHWAYS_20260810%WP34%HOMO SAPIENS Ovarian infertility TBP GDF9 ZP2 CDKN1B TSC2 TSC1 CCND2 GJA4 MTOR CEBPB LHCGR FIGLA MLH1 DAZL AKT1 MSH5 DMC1 VDR INHA PTGER2 SMPD1 FSHR NRIP1 NCOR1 NR5A1 PRLR CREB1 ESR2 FMR1 SYNE2 SMAD2;SMAD3 RAD51 EGR1 CDK4 ATM PGR BMPR1B CYP19A1 ZP3;POMZP3 MALE INFERTILITY%WIKIPATHWAYS_20260810%WP4673%HOMO SAPIENS Male infertility SEPTIN12 PEMT CHD2 RFC1 TMEM132E PON2 CCNT1 PON1 AGO2 MDM2-2 CREBBP ABCB1 ETV5 ARNTL H4C1 DDX20 CLOCK CYP26B1 POLB ATM MTRR HLA-DRA XPC APOB BRCA2 ESR1 MLH1 USP8 SLC46A1 NOS2 DND1 NOS3 TRIP13 XRCC2 ESR2 KLK3;KLK2 GPX1 UBD FOLH1B;FOLH1 NOS1 ERCC1 MTHFD1 AHRR THBS1 MMP2 SHMT1 INSR SOD3 EP300 PRMT6 XRCC3 NQO1 MTR-1 POLG NFE2L2 BCL2 ERCC2 DAZL MSH5 MTHFR FASLG CCNK IHO1 SIRPA;SIRPB1;SIRPG UBR2-2 SLC16A7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RAG1 NANOS1 CAT PRDM7;PRDM9 PRM3 SPATA17 TNF MSH4 MMP9 TSSK6 TSSK4 DDX4 GNAO1 STRA8 MOV10L1 PUM2 CCNT2-1 PIWIL2 CRISP2 EPPIN;EPPIN-WFDC6 PIWIL1 PIWIL4 PIWIL3 SPO11 YBX2 HORMAD2 HORMAD1 PMS2 FAS MSMB PACRG BHMT TEX15 USP26;USP29 LTF CXXC1 ABLIM1 OR2W3 CYP1A1 LRWD1 CDC42BPA MLH3 TCN2 CTCFL BRDT CLU PSAT1 CCNA1 RGS9 KDM3A PARP1 UBE2B AR PEX10 CDK9 XRCC4 XRCC5 LIG4 SOX5 AHR SRD5A2 CYP17A1 REC8 ZINC HOMEOSTASIS%WIKIPATHWAYS_20260810%WP3529%HOMO SAPIENS Zinc homeostasis SLC39A8 SLC30A7 SLC39A7 SLC30A6 SLC39A2 SLC30A8 SLC39A1 SLC30A3 SLC39A4 SLC30A2 SLC39A3 SLC30A5 SLC30A4 SLC30A1 MT3 MTF1 SLC30A9-1 MT2A SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 SLC39A9 SLC39A6 SLC30A10 SLC39A5 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260810%WP615%HOMO SAPIENS Senescence and autophagy in cancer RB1 MAP2K3 CDKN1B MAP1LC3C CXCL14 MTOR MAP2K2;MAP2K1 FKBP8 MAPK1 RAF1 IL24 MDM2-2 SMAD4 PCNA E2F1 IGFBP5 CDC25B ATG14 IGFBP3 INS;INS-IGF2 IGFBP7 CEBPB IL6R CDKN2A RB1CC1 LAMP2 MAP1LC3B2;MAP1LC3B-1 INHBA BMI1 ATG3 VTN BECN1 ATG10 MAP1LC3A IFNG ATG13 IL3 IL6 AMBRA1 ATG7 FN1 THBS1 SPARC ATG16L1 COL3A1 CXCL2;CXCL3;CXCL1-1 CCL3L1;CCL3L3;CCL3;CCL18 SLC39A2 SQSTM1 SLC39A1 SLC39A4 SLC39A3 UVRAG BRAF BCL2 CDKN1A HRAS CXCL8 MLST8 GSN ATG12-1 SERPINB2 ATG5 IL1B SERPINE1 PLAT ING2 IL1A TP53 IRF7 IRF5 SRC PLAU JUN AKT1S1 MAPK14 MMP14 COL1A1 IFNB1-4 GSK3B LAMP1 SH3GLB1 TNFSF15 PTEN ING1 IFI16 CREG1 RSL1D1 RNASEL IL6ST PIK3C3 TGFB1 IGF1 CD44 SMAD2;SMAD3 GABARAPL2 IRF1 BMP2 GABARAP COL10A1 IGF1R ULK1 KMT2A RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260810%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway STAT5A STAT5B PIK3R1 ITGB1 PIK3CA NFKBIA EIF4EBP1 GRB2 KRAS MAPK1 AKT1 HRAS MAPK3 FOXO1-1 TEK BIRC5 SOS1 RAC1 YAP1-1 RAD51 NRAS STMN1 BAD TP53 PTK2 BAX SRC RELA MAPK9 PTPN11 MAPK14 DOK2 MSH2 CRK GRB14-1 MAPK12 GRB7 MAPK13 PXN MAPK11 NCK1 CASP9 IKBKB ANGPT4 CASP7 ANGPT1 IKBKG ANGPT2 RS1 TNIP3-2 ANGPTL1 TIE1 CHUK NOS2 TNIP1 TNIP2 EGFR MAPK8 ERBB2 NFKB1 FN1 NOS1 CTNNB1 MMP2 PAK1 STAT3 MYC RASA1 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260810%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response VCAM1 ITGB2 TNF ICAM1 ITGAL C3-1 C5 ITGA4 IL6 C6 ITGB1 IL1A C7 KNG1 SELPLG CXCL8 SELP SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260810%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis SYT1 VAMP2 GDI1 RAB3A SNAP25 RPH3A RIMS1 NSF UNC13A SYP NAPA STXBP1 STXBP5 STXBP6 CACNA1B CACNA1A CPLX1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260810%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients TGFBR2 ATG16L1 NEDD4 SMAD2;SMAD3 TGFBR1-1 PMEPA1 LDLRAD4 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260810%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX6A1 COX6B1 COX7C COX19 COX18 TACO1 HIGD1A COX7B COX15 PET117 COX17 COX14 COX4I1 COX5A COX10 COA3 CMC1 TMEM177 PNKD SMIM20 COX11 COX20 NDUFA4 COX8A SURF1 COX7A2 COX5B COX6C EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260810%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling TNF CCL5 MAP3K3 IFNB1-4 TRAF1 CCL20 NFKB1 IRAK1 PDLIM7 MAP3K14 IKBKB NFKB2 TRAF6 NFKBIA IKBKG MAP3K7 HSP90AA1 MAPK1 CHUK CXCL8 MAPK8 TRADD RELA GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260810%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism NEU3 ST3GAL1 ST3GAL2 ST3GAL4 ST8SIA6 HEXB HEXA NEU4 ST8SIA1 B3GALT4 ST8SIA5 ST3GAL5 B4GALNT1 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260810%WP4630%HOMO SAPIENS Measles virus infection CDKN1B PIK3CD PIK3R3 TP73 CCND3 CCND2 PIK3R2 PIK3CB PIK3R1 PIK3CA CCNE2 CCNE1 CDK6 CDK4 CD3G CDK2 CD3E CD3D HSPA1L HSPA1A;HSPA1B HSPA6 OAS3 CSNK2A2 HSPA2 CSNK2B CD28 MX1-1 OAS1 CASP9 BAK1 EIF2AK2 CCND1 IL6 HSPA8 TBK1 IL12B EIF2AK4 IL12A BCL2L1 IFNAR2 BBC3 IL2 EIF2AK3 IFNAR1 STAT5A IRAK1 STAT5B FADD IL2RG NFKB2 IL2RA NFKBIA MAVS IL2RB EIF2S1 BCL2 FASLG TAB2 IFIH1 RACK1 MYD88 EIF3H JAK3 APAF1 TNFAIP3 TRADD DDX58 TYK2 CASP8 CLEC4M;CD209-2 CSNK2A1;CSNK2A3 CASP3 MSN FOS IRAK4 RAB9A IRF3 CYCS-1 TRAF3 IL1B BID TRAF6 IL1A BAD TLR9 STAT2 TP53 NFKBIB IRF7 FAS BAX TLR7 TLR4 TLR2 EIF2AK1 RELA JUN MAPK9 IFNB1-4 MAPK10 IRF9 IKBKB IKBKG IKBKE MAP3K7 CHUK MAPK8 CBLB NFKB1 SLAMF1 RCHY1 NECTIN4 RAB9B ADAR JAK1 STAT1 STAT3 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation COPS4 COPS3 COPS8 COPS5 COPS2 GRIP1 HBP1 PRKAA1 TNFRSF13B GDI2 WDR41 EFCAB2 RAB8A RMI2 IQCD TCTE1 IQCG MTOR SMCR8 WDR26 CARM1 PEMT MIEF2 ITPK1 RMND5A RASD1 FNIP1 FNIP2 RANBP9 FOXA1 IRF8 FBXL13 MYO16 MKLN1 GID4 MYO15A GPR85 DRG2 CLTC CLTA BCL6 ETV5 ARNTL CREB1 ROCK1 CLOCK TFE3 YAP1-1 CFL2 ATPAF2-2 CDK1 RMI1 TOP3A RHOA LIMK1 WWTR1 TFEB IFT172 BLM IFT88 TTC30A;TTC30B PRDM1 FOXA2 RAB10 MED9 C9orf72 APP CLEC16A USP8 IFT20 COPS6 TTC26 PARD3 RB1CC1 IFT52 APBB1 PCK1 PRKAG2 ATG13 IFT57 IFT80 ATG101 PRKAB1 HSPB11 IFT22 IFT74 IFT81 IFT27 SHMT1 IFT46 PER1 BCL2L11 PRKN MYC RNF41 BIRC2 CRY2 CRY1 CLUAP1 PPP1R12A ARG2 GPS1 TOLLIP RPTOR MYD88 DRC1 FLCN PPP1R14A TNF MLST8 CLTB NT5M IL1B GAS8 TP53 BAX TLR4 PRKCI RELA JUN SREBF1 CCDC65 PTEN PARD6B HES6 NR1H2 NR1H3 TRAF3IP1 NFKB1 MAP3K14 FHOD1 RRAGA FERD3L ALKBH5 MAEA MPRIP IQCA1 DENR MIGA2 MIGA1 ARMC8 DRC3-1 STAT3 TOM1L2 LLGL1 LDHA ULK1 DRC7 FLII COPS7A PLD6 G6PC1 RAI1 RAB39B PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway MIF AIFM1 PARP1 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP4149%HOMO SAPIENS White fat cell differentiation STAT5A SREBF1 STAT5B NR2F2 EGR2 DDIT3 INS;INS-IGF2 KLF2 CEBPA WNT10B CEBPB EBF1 RORA CEBPD IRF4 NR3C1 CTNNA1 KLF5 TLE3 MECOM ZNF423 FOXO1-1 KLF15 NR1H3 CREB1 RARA IRF3 PPARG GATA3 GATA2 KLF4 TCF7L1 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260810%WP5382%HOMO SAPIENS TGFB Smad signaling TGFBR2 WWTR1 POSTN SPARC CCN2 YWHAG SMAD2;SMAD3 TGFBR1-1 TGFBR3 SMAD4 SERPINE1 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260810%WP5461%HOMO SAPIENS Primary ovarian insufficiency MST1R STAG3 POLR2C PPM1B NBN SOX8 KHDRBS1 BMPR1A PRORP RCBTB1 MEIOSIN POF1B EIF2B2 MEIOB SIL1 NR5A1 SOHLH2;CCDC169-SOHLH2 HFM1 NANOS3 PREPL NOBOX AARS2 FMR1 AIRE SYCP2L HMMR RAD51 WDR62 SYCE1 ANTXR1-1 SOHLH1 KASH5 SWI5 HELQ PMM2 ATM HARS2 DIAPH2 H1-8 HROB LHX8 MCM8 MCMDC2 MCM9 ELAVL2 C1orf146 MRPS22 TWNK BLM SPIDR BMP15-1 C14orf39 ZAR1 ERAL1 GDF9 HAX1 GALT PSMC3IP NOTCH2 DCAF17 AMH SHOC1 CCDC185 MGME1 PRDM1 FOXL2 MND1 XPNPEP2 SPATA33 SALL4 BRCA2 NUP43 ESR1 MLH1 AMHR2 PGRMC1 TP63 EIF4ENIF1 SLX4 FANCI FANCM CAV1 FANCL ATG9A XRCC2 FANCA ESR2 FANCC RFWD3-2 WT1 ATG7 BMP6 LAMC1 ERCC6 ZP3;POMZP3 BNC1 CLPP POLG CPEB1 LARS2 FIGLA DAZL MSH5 DMC1 CENPE FSHR TGFBR3 MSH4 STRA8 EXO1 NUP107 EIF2B1 EIF2B4 POLR3H PCCA PCCB HSD17B1 ALOX12 HSD17B4 EIF2B5 AR COX10 WRN LMNA XRCC4 LIG4 LGR4 GNAS-1 BMPR2 BMPR1B CYP19A1 CYP17A1 SGO2 STAR MONOAMINE GPCRS%WIKIPATHWAYS_20260810%WP58%HOMO SAPIENS Monoamine GPCRs DRD1 DRD3 DRD4 HTR5A CHRM4 CHRM5 HTR1F CHRM2 HTR2A DRD2 CHRM1 ADRA2C ADRA2B ADRA2A ADRB1 ADRB2 CHRM3 HRH1 ADRA1D HRH2 DRD5 HTR1E HTR1D HTR1B HTR2B ADRA1B ADRA1A HTR4 HTR6 HTR7 ADRB3 HTR1A 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome GLUD1;GLUD2 FGFR1 RELN SHOC2 PI4KA GBX2 CLTCL1 RAF1 MAG HIRA PITX2 ACTC1;ACTG2 SLC25A1 ARNTL H4C1 SNAP29 CYP26B1 PAX3 CYP26A1 HES1 CDC45 SEPTIN5 CUL3 MALT1 VWF FOXC2 FOXC1 TSKS ZDHHC8 ZNF274;ZNF74 FOXA2 RCC1 TANGO2 C22orf39 THAP7 SHH TSSK2 FGF8 ASF1A RTN4R TBX1 RTL10 NPRL2 OAT NPRL3 TRMT2A ESS2 PRODH;LOC102724788 EGFR KLHL22 GP5 ALDH4A1 LZTR1 LRRC74B AIFM3 MRPL40 DGCR8 TNPO1 SCARF2 DGCR2 SEPTIN11-1 GP1BB GP1BA RANGAP1 SLC7A4 GNB1L CHRD DEPDC5 CCDC188 PPP1CB ARVCF FGF10 HIRIP3 DROSHA LOC102724770;DGCR6;DGCR6L RANBP1 RBX1 SEPTIN8 RAN CDC42 CLDN3 PRKN GP9 HDAC3 SLC2A4 PLK1 XPO1 BCL2 CDH15 DRD2 ALDH1A2 PAK4 NKX2-5 POLR2A EMC10 P2RX6 GSC2 TP53 MED15 SREBF1 SREBF2 SERPIND1 KPNB1 COMT RTN4 NCOR1 HAND2 UFD1 FGFR2 SRF RORC CBX5 CLDN1 CRKL TXNRD2 ACTA2 CLDN5 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260810%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH2 ACSS2 CS ALDH3A2 ALDH9A1 ACO2 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260810%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis ITGAV TRAF1 STAT4 IL2RA CCR6 CTLA4 FCRL3 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CIITA PTPN22 IRF5 PADI4 IL6ST CD244 PHF19 SLC22A4 CD40 BLK ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260810%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism MTTP DGAT1 SLC27A4 HMGCS1-1 APOA1 LSS IDI1 APOB LDLR HSD17B7 SAR1B APOA4 NPC1L1 MVK MGAT1 FDFT1 ABCG8 MSMO1 CD36 ABCG5 FDPS ACAT2 TM7SF2 EBP MVD NSDHL PMVK SC5D CYP51A1 SQLE DHCR24 FABP2 DHCR7 LBR HMGCR ABCA1 IL1 SIGNALING%WIKIPATHWAYS_20260810%WP195%HOMO SAPIENS IL1 signaling SQSTM1 ATF2 MAP2K3 IRAK1 IRAK2 PIK3R2 PIK3R1 MAP2K2;MAP2K1 NFKBIA MAPK1 TOLLIP AKT1 TAB3 TAB2 TAB1 MYD88 MAP2K6 MAPK3 MAP3K2 MAP3K3 ECSIT IRAK3 IRAK4 IL1B TRAF6 IL1A PELI1 NFKBIB UBE2V1 PELI2 RELA MAPK9 JUN PLCG1 PTPN11 MAPK14 IL1RAP PRKCZ IKBKB IKBKG MAP3K7 MAP2K4 CHUK UBE2N MAPK8 MAP2K7 MAP3K1 NFKB1 MAP3K14 IL1R1 MAPKAPK2 HSPB2 REL VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260810%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RXRA VDR RARA PURINE METABOLISM%WIKIPATHWAYS_20260810%WP4792%HOMO SAPIENS Purine metabolism PRPS1 HPRT1 ADA ADSL ATIC AMPD1 APRT IMPDH1 DGUOK ADSS2 ITPA PNP-1 XDH ENERGY METABOLISM%WIKIPATHWAYS_20260810%WP1541%HOMO SAPIENS Energy metabolism GABPA PPRC1 MAPK14 ATF2 PRKAA1 PPARGC1A GSK3B HDAC1 PPP3CA PRMT1 MEF2B;BORCS8-MEF2B PPP3R1 PPP3CB MEF2A NRF1 PPARA PPARD MEF2C ESRRA FOXO1-1 PRKAG1 PRKAG2 PRKAG3 RXRA CREB1 CAMK2G TFAM-1 MYBBP1A UCP3 PPARG SIRT1 PRKAA2 PRKAB2 SIRT3 PRKAB1 PPP3CC UCP2 MED1 CAMK4 MEF2D PPARGC1B FOXO3 TFB1M EP300 NCOA1 TFB2M BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260810%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders GAMT GLS2 NAGS OTC F7 GPT GATM ARG1 ASS1 F10 GOT1-1 ASL ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260810%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway GCLM TMPRSS2 ACE2 NQO1 IKBKB NOX1 GCLC NFE2L2 IKBKG NFKBIA CHUK GUCY1B1 CXCL8 HMOX1 TNF SLC7A11 PRKG2 RXRA NFKB1 IL6 IRF3 GUCY1A2 IL1B GUCY1A1 CCL13;CCL2 IL12A GSTA3;GSTA5;GSTA1;GSTA2 MMP1 MMP3 RELA KEAP1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260810%WP4830%HOMO SAPIENS GDNF RET signaling axis HOXC11 ROBO2 FAT4 FOXC2 FOXC1 HOXD11 RET HOXA11 SLIT2 EYA1 HNF1B LHX1 GDNF GREM1 PAX2 SOX17 ALDH1A2 GLI3 SALL1 SIX2 SOX11 BMP4 SPRY1 WT1 GATA3 HSPB11 GFRA1 IFT27 CTNNB1 AGTR2 ROBO1 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260810%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy GANC CNMD P4HTM MMP13 COL2A1 FGFR1 PIK3CA ARNT MAPK1 AKT1 JAK2 MAPK3 NTRK1 NGF IBSP FGF23 LAMTOR1 KDR CCN2 FOS AKT2 AKT3 PRKCA RELA JUN HIF1A FOSL2 JUNB SPP1 COL1A1 JUND VHL CEBPB FOSL1 VEGFA NFKB1 FOSB SOX9 FGFR2 RELB COL3A1 COL10A1 DDR2 STAT3 RUNX2 ACAN FGFR4 EPAS1 FGFR3 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5407%HOMO SAPIENS 15q11q13 copy number variation SPEF1 SMC5 SMC6 CXADR NSMCE3 HDAC1 SIN3A NSMCE2 NSMCE1 EID3 GJD3 GJC2 CANX NECAB3 LYPD6 UBN1 GCOM1;MYZAP TRPM3 RIC3 FANCD2 SLF1 SLF2 FAM189A1 KAT2B CGN CDC42BPB CREBBP DNMBP APBA2 ANKRD2 CHRNA7;CHRFAM7A SERPINH1 RELA CCL5 MTMR10 APP KLF13 OTUD7A TRPM1 FAN1 STXBP1 FANCI GJA1 CALM1 OCLN-1 MITF TJP1 STX1A TJP3 TJP2 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2879%HOMO SAPIENS Farnesoid X receptor pathway SLC27A5 RXRA PPARGC1A IRS2 ABCB11 NR0B2 SLC10A1 FKBP5 IP6K3 NR1H4 ABCB4 BAAT CYP7A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP8B1 FGF19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLCO2B1 SULT2A1-4 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260810%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway CERK SGMS1 SGMS2 UGT8 UGCG SGPL1 SMPD1 KDSR CERS3 CERS4 CERS6 SGPP2 SGPP1 DEGS1 DEGS2 CERS1 CERS2 PLPP3 PLPP2 PLPP1 ASAH1 CERS5 SPTLC1 SPHK2 SPHK1 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260810%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc PCK1 PC PDHA1 IDH1 FH MDH1 CS SDHA DLD DLST ACO1 SUCLG2 ACLY OGDH IDH3A DLAT TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260810%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SHH FGF8 NKX2-1 FOXG1 SMAD2;SMAD3 TGIF1-1 GLI3 NODAL TGIF2 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260810%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits VCAM1 TNC POSTN JAG1 VEGFA NOTCH1 TCF7 LEF1 VHL CXCR4 TCF7L2 SRC WNT2 EPAS1 PIK3CG TCF7L1 CYTIP LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260810%WP5314%HOMO SAPIENS Lactate shuttle in glial cells NUDT14 SLC2A1 SLC16A1 SLC1A2 SLC16A3 HK1 LDHA SLC16A7 SLC4A4 CA2 LDHB CA4 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260810%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B3GALNT1 GALNT16 B4GALT2 ST6GALNAC3 B4GALT1 GALNT1 CERK SGMS1 SGMS2 B3GALT2 SPHK2 UGT8 B3GALT1 SPHK1 UGCG SGPL1 KDSR CERS3 SGPP2 SGPP1 B4GALNT1 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260810%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment ITGB6 CCL5 CSF1R HLA-DRA CSF1 IFITM3;IFITM2;IFITM1 CXCR3 CCR2 CXCL10 CXCL12 FASLG TGFB1 BAG3 KDR LAG3 VEGFA NRP1 CSF2RA CD86 CXCR4 CCR5 CD80 FAS CCL13;CCL2 CTLA4 CSF2 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260810%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle FH IDH3G MDH2 SUCLA2 IDH3B SUCLG1 SDHC CS SDHD SDHA SDHB DLD DLST SUCLG2 OGDH ACO2 IDH3A IDH2 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2276%HOMO SAPIENS Glial cell differentiation MSN TPPP MAG MBP GAP43 PLP1 CNP PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260810%WP3527%HOMO SAPIENS Pre implantation embryo PBX1 TFAP2E;TFAP2B DDIT3 IRX5 MTA3 SIX3 SOX8 MYBL1 IRF4 ZFP42 ESRRA SOX11 NANOGNB CELF3 FOXQ1 AQP9 AQP3 NR3C2 ZFP36 KHSRP TEAD4 BATF3 ATP1A1 PADI6 BARX2 HNRNPAB MACROH2A2 ZFP36L2 LEUTX NLRP5 DPRX-1 MOS TPRX1;RAX2 ZSCAN4 ELAVL1 TCF7L1 SMARCA4 ZAR1 NKX2-1 POU5F1;POU5F1B FOXD1 E2F5 TBX3 NANOG;NANOGP8 SOX2 MXD1 DNMT3L DLX2 FOSB EGR1 GATA3 CDX2 GATA2 KLF4 CDH1 DPPA3 PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260810%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway SNCAIP MAPK14 PINK1 MAPK12 MAPK13 MAPK11 CASP9 CASP7 UBB;UBC UCHL1 CCNE2 UBE2J2 CCNE1 TH ATXN2 EPRS1 APAF1 UBA7 UBE2J1 LRRK2 SLC6A3 CASP3 UBA1 DDC CYCS-1 PARK7 HTRA2 UBE2L6 GPR37 SEPTIN5 SYT11 PRKN CASP6 UBE2G1 CASP2 SNCA UBE2G2 ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260810%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism HSD17B1 HSD17B2 HSD17B4 HSD17B7 HSD17B10 COMT CYP2C9;CYP2C19 HSD17B3 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP19A1 HSD17B8 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1B1 CYP1A2 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260810%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E PTPN11 NFATC2 NFKB1 IFNG PDCD1 NFATC3 CD3G NFATC1 CD3E CD3D NFATC4 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ZAP70 BATF LCK STAT3 CD8A CD8B;CD8B2 NFAT5 PDCD1LG2 CD274 JUN LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260810%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer FZD5 FZD8 HNRNPK CCND3 CCND2 ATF3 SOX17 ROR1 CSNK2A1;CSNK2A3 CDK6 MACROH2A2 SFRP1 FRAT2 RUVBL1 HNRNPU FZD10 PLAU CSNK2A2 DKK2 JUN TCF7L1 WNT5B DKK4 WIF1 SFRP4 CSNK2B WNT2B APC CTBP2 TCF7 GSK3B WNT6 DVL1 DVL2 DVL3 WNT3 NOTUM WNT4 FZD1 MAP3K7 WNT10B APC2 PORCN WNT10A FZD3 EZH2 FZD2 WNT1 FZD7 CXXC4 WNT2 FZD6 FZD9 FOSL1 WNT3A CCND1 WNT7B CER1 TPTEP2-CSNK1E;CSNK1E RYK-1 SFRP5 WNT5A CTNNBIP1 SOST CSNK1A1 AXIN1 CDK8 KREMEN1 DKK1 SERPINF1 AXIN2 WNT16 CHD8 ROR2 SENP2 LEF1 SFRP2 LRP5 CTBP1 NKD1 LRP6 NKD2 WNT11 NLK TCF7L2 WNT7A CTNNB1 MYC TFAP2A ESTROGEN METABOLISM%WIKIPATHWAYS_20260810%WP697%HOMO SAPIENS Estrogen metabolism UGT1A1;UGT1A6 STS NQO1 GSTM1;GSTM2-1 GSTA3;GSTA1 COMT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP1B1 ARSD-1 ARSL CYP1A2 ESTROGEN SIGNALING%WIKIPATHWAYS_20260810%WP712%HOMO SAPIENS Estrogen signaling MAPK14 CREB1 FOS NFKB1 GNGT1 IKBKB BRAF MAP2K2;MAP2K1 SP1 PIK3CA GPER1 ELK1 GNAS-1 IKBKG ESR1 BCL2 MAPK1 AKT1 CHUK GNB1 PRKACA-1 JUN MAPK9 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP304%HOMO SAPIENS Kit receptor signaling PRKCB STAT5A STAT5B PIK3R2 PIK3R1 MAP2K2;MAP2K1 GRB2 MAPK1 AKT1 RAF1 JAK2 HRAS MAPK3 SHC1-1 RPS6KA1 RPS6 GAB2 TEC RPS6KB1 SOS1 PRKCA BAD SRC SH2B2 MAPT FOXO3 INPP5D FYN MATK PLCG1 SOCS6 PTPN11 MAPK14 CRK GRB7 PTPN6 GRB10 DOK1 MAPK8 LYN CBL KITLG KIT MITF SOCS1 STAT1 STAT3 CRKL RPS6KA3 VAV1 EP300 BTK CELL CYCLE%WIKIPATHWAYS_20260810%WP179%HOMO SAPIENS Cell cycle STAG2 ESPL1 RB1 CDKN1B CCND3 E2F3 CCND2 YWHAE CHEK2 CHEK1 SMC1A CDC25C CDC25A CCNE2 CCNE1 YWHAG CUL1 PRKDC MDM2-2 YWHAH CCNB3 SKP1 CCNB2 SMAD4 PCNA E2F1 ABL1 SFN MCM7 GADD45B SKP2 ORC5 GADD45A ORC4 ORC6 ORC1 GADD45G ORC3 ORC2 CDK6 CDC7 DBF4 CDK4 MCM3 CDK2 MCM5 CDK1 MCM6 ATM ATR CDC45 TTK CDC23 CDC25B CDC27 CCNA2-1 ANAPC7 CDKN1C ANAPC4 ANAPC5 ANAPC1 ANAPC2 ANAPC10 ANAPC11 FZR1 E2F2 CDKN2D CDC6 CDKN2B CDKN2C WEE1 CDKN2A TGFB3 CCND1 CDC16 CDC20 MAD2L2 RBX1 MCM2 MYC EP300 HDAC2 TGFB2 HDAC1 PLK1 CDKN1A YWHAB YWHAQ STAG1 BUB3 BUB1 MAD1L1 YWHAZ TP53 CDC14A CCNA1 CDC14B ANAPC13 PKMYT1 RBL2 RBL1 MCM4 WEE2 TFDP1 GSK3B TFDP2 E2F4-1 E2F5 TGFB1 ZBTB17 CDK7 SMAD2;SMAD3 CCNB1 SMC3 RAD21 PTTG1;PTTG2 CCNH SMC1B EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260810%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways PRKAA1 PPARGC1A PIK3CD PIK3R3 TSC2 TSC1 PIK3R2 AHI1 PIK3CB PIK3R1 SIN3A SLC12A2 MTOR MAP2K2;MAP2K1 PIK3CA EIF4EBP1 MAPK1 AKT1 RAF1 EIF4E MAPK3 DEPTOR RICTOR CREB1 AKT2 AKT3 PRKAA2 ELK1 NTRK2 SLC12A5 REST ITPR1 ABCA1 APOE CKB BNIP3 SP1 GABRB3 CASP7 GABRB2 GABRB1 GABRG3;GABRG2 GABRE GABRD EGFR GABRQ GABRA2 GABRA1 GABRP GABRA6 PRKAG1 PRKAG2 GABRA5 HTT GRM1 PRKAG3 GABRA4 GABRA3 IL6 GABRG1 RAB3A KIF5A PRKAB2 PRKAB1 BCL2L1 BCL2L11 PIK3R5 HDAC2 HDAC1 BCL2 PIK3R6 RPTOR RHEB RPS6KA5 HRAS PIK3CG CASP8 MLST8 RPS6KB1 CASP3 DHCR7 OPA1 IL1B BID PRR5L BAD BAX MAP3K10 MAPK9 AKT1S1 HMGCS1-1 ABCG4 SREBF2 MAPK10 RAB3GAP1 IKBKB PTEN PIK3C2G PIK3C2A PIK3C2B MAP2K4 CYP46A1 MAPK8 MAP2K7 NR1H2 CYP51A1 PIK3R4 EGF NFKB1 ABCG1 NEUROD1 MBP HMGCR HAP1 BDNF HMGCS2 NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260810%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium TCF4 MRE11 RET DLL1 RELN NTRK1 MECP2 NGF CDK5 VLDLR PAX6 ASCL1 MARK2 HES1 NDEL1 NTRK2 NTRK3 IL17A MAP1B MAPT PLXND1 HEY1 NOTCH1 DISC1 GSK3B FAIM LRP8 DAB1 NEURL1 SEMA4A NEUROG3 APP CXCL12 ID2-1 RTN4R NRG1 KDM1A MEF2C RTN4 SOX2 ERBB4 NUMB NUMBL JAG1 PAFAH1B1 CDK5R1 GHRL AGRN NEUROD1 MAP2 NGFR STAT3 MYC BDNF PSEN1 ID1 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260810%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism MTTP SLC2A4 AKT2 APOB HADHB-1 ESR1 ACADM NOS3 PPARGC1B SOD2 PPARA ACLY ESRRA STK11 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260810%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ MAP3K1 MAPK1 RAF1 CHUK NFKB1 MAP2K6 RRAS MAP3K14 IKBKB TRAF6 NFKBIA IKBKG PI3K AKT SIGNALING%WIKIPATHWAYS_20260810%WP4172%HOMO SAPIENS PI3K Akt signaling PDGFD PDGFC GNG13 LPAR5 CDKN1B PRKAA1 GNB3 PIK3CD PIK3R3 BRCA1 GYS2 GNGT1 TSC2 CCND3 TSC1 PIK3R2 CCND2 OSMR PIK3CB PIK3R1 PHLPP2 PHLPP1 MTOR MAP2K2;MAP2K1 PIK3CA RELN VEGFB OSM EIF4EBP1 KRAS VEGFC VEGFD MAPK1 AKT1 CCNE2 RAF1 EIF4E CSF3R CCNE1 CHRM1 FGF3 MDM2-2 MAPK3 IRS1 COMP PDGFRB FGF6 PDGFRA STK11 FGF9 ITGB3 TNN TNR NGF IBSP F2R ITGAV PGF FGF23 COL4A6 LAMA2 LAMA1 LAMA3 PKN3 LAMC2 EFNA5 CDK6 LAMB3 AKT2 EFNA4 LAMB1 AKT3 CHAD FGF20 CDK4 PRKAA2 FGF22 CDK2 FGF17 EFNA1 NTRK2 PTK2 EFNA3 FGF14 EFNA2 GNB2 FGF18 GNB1 GNB4 PKN2 IL7R PKN1 FGF13 FGF12 FOXO3 FGF11 HSP90AB1 LAMC3 VWF PPP2R5B PPP2R5A PPP2R5D IL3RA EIF4E2 THBS4 GNG2 GNG5 PPP2R3C GNG4 CASP9 GNG8 ANGPT4 TGFA HSP90AA1 ITGA8 NOS3 TNC ITGA2B TNXB ITGB5 LAMB2 LAMA4 ITGA1 FN1 LAMC1 EPHA2 THBS2 THBS1 COL1A2 NGFR COL4A2 INSR COL4A1 CREB3L3 ITGA10 CREB3L4 IL2 FGFR4 COL6A2 MYC ITGA11 FGFR3 CREB3L1 COL6A1 CREB3L2 FLT3 FLT4 COL6A3 ITGB6 ATF2 ATF4 ITGB8 ITGB7 ITGA4 ITGA2 IL2RG THBS3 ITGA7 IL2RA ITGA6 IL2RB BCL2 LPAR4 GRB2 ITGA5 CDKN1A MET FASLG FGF5 SGK1-1 RHEB ITGA9 JAK2 JAK3 HRAS NTRK1 ITGB4 TEK PPP2R1B CREB3 KDR SOS1 RAC1 SOS2 CREB5 ATF6B NRAS PRKCA LPAR6 BAD TP53 GHR PPP2R1A CD19 EPOR PIK3AP1 PPP2R2A;PPP2R2D COL1A1 GSK3B FGF2 IKBKB G6PC3 ANGPT1 IKBKG COL6A6 COL6A5 ANGPT2 CHUK FGF21 PDPK1 PPP2CB;PPP2CA PPP2R5E EGF IGF1 PPP2R5C NFKB1 IL7 FGFR2 PPP2R3B JAK1 PPP2R3A PPP2R2C IL4R PPP2R2B CSF3 IGF1R IL4 FGF19 GNB5 COL2A1 FGFR1 ITGB1 FLT1 THEM4 CREB1 SGK3;C8orf44-SGK3 FGF7 CSF1R CSF1 MCL1 EPO PDGFB PDGFA FGF1 FGF4 INS;INS-IGF2 NTF4 COL9A1 ITGA3 COL9A3 COL9A2 FGF8 PRL IL6R COL4A4 EGFR COL4A3 COL4A5 CCND1 HGF FLT3LG PCK1 LAMA5 PRLR VTN VEGFA IL3 IL6 KITLG KIT FGF10 BCL2L1 IFNAR2 PCK2 HSP90B1 BCL2L11 IFNAR1 PIK3R5 EIF4E1B PIK3R6 RPTOR G6PC2 EIF4B RPS6 PIK3CG IGF2 MLST8 RPS6KB1 RPS6KB2 SYK LPAR1 TLR4 TLR2 RELA SPP1 RBL2 IFNB1-4 PTEN CHRM2 MYB LAMB4 GYS1 TCL1B TCL1A CDC37 DDIT4 BDNF LPAR2 LPAR3 G6PC1 GNG10 NTF3 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260810%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma PDK1 TSC2 TSC1 MTOR PTEN TGFA GRB2 KRAS AKT1 RAF1 RPTOR RHEB JAK2 JAK3 HRAS BTC TYK2 EGF SOS1 SOS2 AKT2 NRAS AKT3 EREG JAK1 STAT3 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260810%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway MAPK14 MAP2K3 MAP2K2;MAP2K1 BRAF PIK3CA HTR1F HTR2A MAPK1 PDPK1 JAK2 MAP2K6 RPS6KA5 MAPK3 MAP3K1 HTR1E GNAO1 HTR1D CREB1 HTR1B FOS GNAI3 GNAI1 GNAI2 SRF ELK1 ELK4 RHOA MAPKAPK3 RAP1A MAPKAPK2 RASGRF1 GNAQ STAT3 ITPR1 RASGRP1 HTR1A AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260810%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways CLCN7 OSTM1 SNX10 TNFSF11 TCIRG1 NFKB1 PLEKHM1 TNFRSF11A IKBKB RAB7A TRAF6 OXYTOCIN SIGNALING%WIKIPATHWAYS_20260810%WP2889%HOMO SAPIENS Oxytocin signaling CD38 OXTR GNAQ PLCD1 HINT1 PATHWAY%WIKIPATHWAYS_20260810%WP5523%HOMO SAPIENS HINT1 pathway TCF4 NFATC2 GTF2H1 GTF2H3 USF2 FOS SH3RF1 NFKB1 GTF2H4 CDK7 ERCC3 MNAT1 MITF ERCC2 KARS1 HINT1 CTNNB1 RUVBL2 GTF2H2C;GTF2H2C_2;GTF2H2 RUVBL1 CCNH JUN MAPK9 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260810%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CACNA1G CHRNA3 CHRNB4 CACNA1C OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260810%WP1434%HOMO SAPIENS Osteopontin signaling MMP9 ITGAV SPP1 NFKB1 MAP3K14 IKBKB MAP2K2;MAP2K1 MAPK1 CHUK MAPK3 PLAU ITGB3 RELA FOLATE METABOLISM%WIKIPATHWAYS_20260810%WP176%HOMO SAPIENS Folate metabolism HBA2;HBA1 CTH AHCY MTR-1 NFKB2 SLC19A1 MTHFR MAT1A DHFR2;DHFR CAT TNF ICAM1 CRP FGB FOLR1 FGA IL1B SERPINA3 FGG ALB SERPINE1 PLAT SAA2;SAA1 SAA2-SAA4;SAA4 PLG TP53 CCL13;CCL2 F7 MTRR ABCA1 SCARB1 RELA F2 APOA1 CSF1 APOB LDLR INS;INS-IGF2 FLAD1 RFK ST20-MTHFS;MTHFS SLC46A1 IZUMO1R GART SOD2 FOLR2 IFNG NFKB1 CBS;CBSL IL6 GPX1 GPX4 GPX6 MPO MTHFD1 MTHFD2 SHMT2 SHMT1 INSR IL2 IL4 SOD3 HBD;HBB SOD1 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260810%WP3878%HOMO SAPIENS ATM signaling in development and disease HDAC4 MAPK14 ATF2 MRE11 RNF8 MAPK12 TSC2 MAPK13 MAPK11 CHEK2 CHEK1 MTOR MDC1 IKBKG NBN TP53BP1 HSPB1 SMC1A CDC25A TRIM28 PRKDC BUB1 RIF1 RNF20 G6PD ATMIN-1 PPP2CB;PPP2CA STK11 RNF40 CEP63 LMNB2 KAT5 AURKB NFKB1 DCLRE1C RAD50 CDK5 NHEJ1 CDK2 ATM TP53 PPM1D ATR RNF168-1 RBBP8 HMGN1 PPP5C CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260810%WP5193%HOMO SAPIENS Cholesterol synthesis disorders SQLE HMGCS1-1 DHCR24 LSS DHCR7 IDI1 LBR MVK FDFT1 HMGCR MSMO1 FDPS EBP MVD HSD3B1;HSD3B2 PMVK CYP51A1 SC5D NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling MAPK14 PIK3CD COL1A1 MAPK12 MAPK13 MAPK10 PXN MAPK11 MAP2K2;MAP2K1 ITGB1 GRB2 KRAS MAPK1 RAF1 EGFR HRAS MAPK8 AREG TLN1 SOS1 NRAS AKT3 ITGA1 FN1 PTK2 SRC MAPK9 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260810%WP4537%HOMO SAPIENS Hippo YAP signaling NDRG1 STK38L RASSF1 YAP1-1 MAP4K2 TEAD1 MINK1 TEAD2 STK3 TEAD3 TEAD4 SAV1 TNIK CXCL10 WWTR1 LATS1 NF2 MAP4K1 MST1 MAP4K3 LATS2 MAP4K4 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260810%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 TNF TGFB1 CLDN4 ALPL ITGB1 ITGA6 NRG3 AKT1 SFRP1 ZEB2 TERT CCND1 CDH1 MYC ERBB4 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260810%WP247%HOMO SAPIENS Small ligand GPCRs PTGFR GPR50 CNR1 S1PR4 PTGDR S1PR1 S1PR3 PTGIR S1PR2 LPAR1 PTGER4 TBXA2R PTGER1 PTGER2 MTNR1A PTGER3 MTNR1B CNR2 PTAFR IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260810%WP5172%HOMO SAPIENS Iron metabolism disorders CYBRD1 CP HEPH FTH1 TF STEAP3 TFRC FTL-1 BCS1L TFR2 SLC40A1 HJV HAMP UQCRFS1 SLC11A2 HFE MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260810%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms ITGB2 ITGB6 ITGB8 ITGB7 MAPK10 ITGB1 SGMS1 NF2 MAP4K1 MST1 YWHAQ CTNNA1 PAK3 PAK2 PAK5 ACTC1;ACTG2 MAPK8 PAK4 ACTG1 ITGB3 ITGB4 LIMD1 BUB1B-PAK6;PAK6 YAP1-1 ITGB5 TEAD1 MAP4K2 TEAD2 STK3 TEAD3 ACTA1 SAV1 TEAD4 WWTR1 LATS1 SRC MAP4K5 ACTB-1 MAP4K3 CTNNB1 MAP4K4 PAK1 ACTA2 CDH1 MAPK9 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260810%WP5399%HOMO SAPIENS NPHP1 deletion syndrome MAPK1 FLNA BCAR1 FLNB FLNC MAPK3 PTK2B INVS NPHP1 RPGRIP1L SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260810%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation IKBKE TBK1 IFNB1-4 IRF3 TOMM70 TRAF3 DDX58 TRAF6 MAVS ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260810%WP2197%HOMO SAPIENS Endothelin pathways GNG13 CAD EDNRB NPY CALCRL MAP2K2;MAP2K1 ECE1 CNN1 EDN1 GNA15 MAPK1 NPY1R CALCA RAF1 NOS3 ADRB1 RIIAD1 MYLK EDNRA CALM1 GNAI1 RAMP1 PRKCA ADRA1A ATP2A2 GNAS-1 PTGIR MYL1 ADCY10 PLCB1 GNB5 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP2542%HOMO SAPIENS Sulindac metabolic pathway MSRA FMO3 MSRB2 MSRB3 CYP1B1 CYP1A2 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260810%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 MAPK14 CREB3 CREB1 ATF4 NFKB1 MAPK12 MAPK13 IL6 CREB5 IL10 MAPK11 CD14 IL1B NFKB2 CCL13;CCL2 RELB TLR4 CREB3L3 CREB3L4 CREB3L1 REL RELA CREB3L2 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260810%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt IGF1 SST GHRH GNRH1 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway COMT VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260810%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases TNF MAP3K1 MAPK14 MAP2K3 RXRA MED14 NFKB1 IL6 SMAD2;SMAD3 NFATC1 IKBKB PPP3CA NFKBIA IKBKG PPP3R1 DUSP1 CHUK VDR NR3C1 MAP2K6 SMAD4 RELA FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260810%WP5428%HOMO SAPIENS FGFR4 p G388R signaling STAT3 IL10 FGFR4 CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260810%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway POLR2F RIPK1 FADD IL33 NFKBIA MAVS CYLD CXCL10 POLR1C POLR1D CASP10 TRADD DDX58 CASP8 TRIM25 CGAS ATG12-1 RIPK3 RNF125 POLR2E NLRX1 POLR2H IRF3 ATG5 POLR2L ISG15 IL1B POLR3GL STING1 IRF7 NFKBIB POLR3A POLR3B POLR3C POLR3D POLR3F POLR3G POLR3H RELA POLR3K CCL4L2;CCL4L1;CCL4 CCL5 IFNB1-4 PYCARD IKBKB CASP1 IKBKG IKBKE TREX1 CHUK IL18 AIM2 ZBP1 NFKB1 IL6 ADAR TBK1 POLR3E CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260810%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia AKT1S1 PDK1 MAPK11 IKBKB MTOR TNFRSF12A NFKB2 IKBKG NFKBIA CEBPB AKT1 RPTOR CHUK IL6R ACVR2A TNFRSF1A MSTN SMAD4 TNF MLST8 FBXO32 MAP1LC3A TRIM63 IGF1 NFKB1 IL6 SMAD2;SMAD3 IL1B IL1A IL1R1 JAK1 RELB IGF1R STAT3 FOXO3 REL RELA EP300 TNF ALPHA SIGNALING%WIKIPATHWAYS_20260810%WP231%HOMO SAPIENS TNF alpha signaling BIRC3 MAP2K3 CYBA TRAF1 KSR1 RIPK1 FADD KSR2 TNFRSF1B MADD PLK1 OTUD7B GLUL RFFL NFKB2 NFKBIA GRB2 KRAS MAPK1 AKT1 TAB3 RAF1 TAB2 TAB1 CUL1 MAP2K6 MAP3K5 HRAS MAPK3 BTRC APAF1 CREBBP TNFAIP3 SKP1 TRADD CASP8 TNF TRAF2 MAP3K3 CSNK2A1;CSNK2A3 CASP3 RIPK3 SOS1 RAC1 TANK NRAS MAP4K2 SMPD2 BID TXN BAD NFKBIB BAX PSMD2 MAPK9 JUN PYGL NFKBIE PRKCZ CASP9 IKBKB NOX1 CASP7 IKBKG RFK MAP3K7 FBXW11 HSP90AA1 MAP2K4 CHUK TNFRSF1A MAPK8 PPP2CB;PPP2CA MAP2K7 MAP3K1 PTPRCAP NSMAF NFKB1 NOXO1 TRAP1 MAP3K14 DIABLO-1 TBK1 MAP3K8 BCL2L1 CDC37 CFLAR REL BIRC2 CREATINE PATHWAY%WIKIPATHWAYS_20260810%WP5190%HOMO SAPIENS Creatine pathway GAMT OAT GATM CKB SLC6A8 HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260810%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis DRD1 MAPK14 HNRNPL PPARGC1A CCND2 BCL2 MAPK1 PRL RPS6KA5 CAMK2A RPS6KA1 NCAM1 NGF CAMK2B CREB1 NRXN2 CAMKK1 CALM1 CAMKK2 SYT2 NRXN1;NRXN3;NRXN2 PRKCA SYT12 NRXN3 CAMK4 BDNF ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260810%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 MAFK MAFF MAFG MAPK8 MAP2K2;MAP2K1 SP1 CYP2E1 NFE2L2 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation DYNC1H1 DISC1 PAFAH1B1 YWHAE DDC CDK5 DCTN5 DCTN2 NDEL1 DCTN3 DBH YWHAB YWHAQ YWHAG TH YWHAH DCTN6 DCTN1 PPP2CB;PPP2CA DCTN4 YWHAZ AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260810%WP1403%HOMO SAPIENS AMP activated protein kinase signaling ACACA PRKAA1 PIK3CD CPT1B GYS2 PIK3R3 TSC2 SLC2A4 TSC1 STRADA PIK3R2 PIK3CB PIK3R1 LEPR MTOR CAB39 PIK3CA FASN EIF4EBP1 CDKN1A AKT1 CRTC2 RPTOR STK11 PIK3CG PRKACB-1 RPS6KB1 RPS6KB2 PFKFB3 AKT2 ADRA1B PRKAA2 ADRA1A ADIPOR1 TP53 PLCB1 ELAVL1 CCNA2-1 HNF4A ACACB CCNA1 SREBF1 INS;INS-IGF2 EEF2K PIK3C3 ADIPOR2 LIPE PRKAG1 PRKAG2 PRKAG3 CAMKK1 CAMKK2 PRKAB2 EEF2 PRKAB1 CCNB1 STRADB GYS1 SLC2A4RG ADIPOQ LEP HMGCR PPARGC1B INSR CPT1C CPT1A OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260810%WP408%HOMO SAPIENS Oxidative stress response CYBB MAPK14 JUNB MAPK10 NOX3 NQO1 NOX1 GCLC SP1 TXNRD1 NFE2L2 MAOA MGST1 NFIX SOD2 CAT HMOX1 GSTT2B;GSTT2 XDH GSR TXN2 UGT1A1;UGT1A6 FOS NFKB1 GPX1 NOX5 NOX4 TXNRD2 CYP1A1 SOD3 SOD1 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260810%WP3934%HOMO SAPIENS Leptin and adiponectin ADIPOR1 PRKAG1 ACACA PRKAA1 ADIPOQ LEP ADIPOR2 LEPR CPT1A PRKAB1 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260810%WP5178%HOMO SAPIENS Disorders of fructose metabolism KHK SORD PGM1 SLC5A1-1 PFKL GPI TPI1 ALDOB GLYCTK FBP1 HK1 SLC2A2 ALDH1A1 G6PC1 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260810%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies TSLP CRLF2 IL25 IL1RL1 IL33 OSMR IL2RG IL13RA1 FCER1A IL5 STAT6 IL4R IL31RA DEFB103A;DEFB103B MS4A2 STAT3 JAK3 IL13 FCER1G IL4 TYK2 TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260810%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NMRK2 NMNAT3 NMNAT2 AADAT NADSYN1 NMNAT1 HAAO NAMPT QPRT NAPRT KMO TDO2 KYNU AFMID NMRK1 IDO1 ID SIGNALING%WIKIPATHWAYS_20260810%WP53%HOMO SAPIENS ID signaling RB1 SREBF1 RBL2 RBL1 CDK2 ELK1 ID3 ELK4 ID2-1 PAX5 MYOD1 PAX2 CCNE1 ELK3 ID1 PAX8 CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260810%WP2023%HOMO SAPIENS Cell differentiation expanded index HDAC5 TLX3 TLX1 PAX7 SRF MEF2B;BORCS8-MEF2B ID2-1 MEF2A EZH2 KLF4 MYOD1 MEF2D STAT3 RUNX2 TLX2 MEF2C LEFTY2;LEFTY1 SOX2 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260810%WP5166%HOMO SAPIENS Glyoxylate metabolism PRODH2 AGXT GRHPR LDHA ALDH4A1 DAO SLC26A1 PXMP2 HAO1 GOT2-1 HOGA1 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260810%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II CTSD ACE CTSG REN CMA1 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260810%WP500%HOMO SAPIENS Glycogen synthesis and degradation PPP2R5B PYGB GSK3A PPP2R5A PYGM PPP2R5D GBE1 PHKG1 PYGL PHKB GYG2 PHKA1 PPP2R2A;PPP2R2D GYS2 PHKA2 HKDC1 GSK3B AGL-1 PHKG2 GYG1 PPP2CB;PPP2CA PPP2R5E PPP2R1B PGM1 PPP2R5C HK3 CALM1 CALM3;CALM1 GYS1 PPP2R3B CALM2 PPP2R3A PPP2R2C PPP2R2B UGP2 HK2 HK1 PTPA PPP2R1A SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260810%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response BSG CCL3L1;CCL3L3;CCL3;CCL18 IFNAR1 IFIT2 HDAC2 AP1G1 RIPK1 FADD CXCL17 MAVS CXCL10 PPBP CXCL11 HAVCR2 CXCL9 CXCL8 TRADD DDX58 DHX58 CASP8 TRIM25 TNF LARP1-1 TRAF2 LAG3 IL10 TANK IRF3 TRAF3 TRAF6 STAT2 IRF7 CCL13;CCL2 TLR7 CXCL13 PF4;PF4V1-1 NUP98 CCL4L2;CCL4L1;CCL4 CCL5 TRAF5 IFNB1-4 MX1-1 IFITM3;IFITM2;IFITM1 ACE2 RAE1 CXCL12 TP53I3 IL6R CD160 TGFB1 NFKB1 IL6 SMAD2;SMAD3 CXCR2 TBK1 CSF2 JAK1 IFNAR2 STAT1 CXCL2;CXCL3;CXCL1-1 CXCL5;CXCL6 TFAP2A EP300 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260810%WP80%HOMO SAPIENS Nucleotide GPCRs LPAR4 LTB4R P2RY6 P2RY4 ADORA2A P2RY2 ADORA3 ADORA2B P2RY1 LPAR6 ADORA1 H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260810%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer RB1 CDK8 JAG1 CDK4 TULP3 MED1 MACROH2A1 CTNNB1 SOX4 CCND1 CSRP2 CDH1 E2F1 PMAIP1 POLYOL PATHWAY%WIKIPATHWAYS_20260810%WP690%HOMO SAPIENS Polyol pathway ALDOB KHK SORD AKR1B1 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260810%WP2333%HOMO SAPIENS Trans sulfuration pathway MAT2B CTH GCLM CSAD MPST AHCY CBS;CBSL DNMT1 MTR-1 GOT1-1 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260810%WP5546%HOMO SAPIENS 22q11 2 distal CNV RNF19B PPIL1-1 VPREB1 CHEK1 CWC22 ROPN1L ARIH1 SRRM2 RSPH6A CUL2 ZNF280D;ZNF280A ELOC-1 CRNKL1 DHX16 PDIA4 MAPK1 IGLL5;IGLL1 RAB36 ERP29 NEDD4 PPIE DYDC1 UBA6 MDM2-2 CABP1 SNRPA1 AK8 SDF2L1 CWC15 TDRD3 SF3B4 HYOU1 SF3B5 BCR IQUB SF3B2 TOP3B SF3B3 CCDC116 BUD31 SNRNP200 PLRG1 NME5 YDJC RBM22 CAMK1 PPM1F RNF113A PRAME SNRPB2 RILP SNRPG-2 UGGT1 PPIL2 SF3A1 CDC5L YPEL1 PPIL4 SF3A2 PPIL6 SNRNP40 PHF5A CAMK4 SF3B1 RPS27A RPS15 PDIA2 RPS14 FAU RPS17 RPS16 RPS19 CDC16 RPS18 RPS11 CBL RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 PPIB SF3A3 RPSA RBX1 CALR-1 PAK1 HSP90B1 RPS15A PRKN RPS3 DNAJB13 RPS2 XBP1 HSPA5 RPS29 DNAJB11 RPS20 RPS21 ATF6 RPS24 RPS23 CANX GNAZ RACK1 CAMK2A PAK2 RPS6 SNW1 TP53 RSPH9 PTPA AQR CD79B CD79A RSPH3 LRP4 EFTUD2 SNRPD2 SNRPD1 SNRPD3 ELOB UBA1 SOX9 UBE3A SNRPF SNRPB XAB2 PRPF8 SNRPE-2 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260810%WP3924%HOMO SAPIENS Hfe effect on hepcidin production TMPRSS6 BMP6 HJV HAMP ID1 SMAD7 HFE ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260810%WP5293%HOMO SAPIENS Acute myeloid leukemia ZBTB16 PIK3CD STAT5A PIK3R3 STAT5B PIK3R2 PIK3CB PIK3R1 CD14 MTOR MAP2K2;MAP2K1 BRAF PIK3CA EIF4EBP1 GRB2 KRAS MAPK1 AKT1 RAF1 DUSP6 HRAS PPARD MAPK3 PIM2 RPS6KB1 RPS6KB2 PML SOS1 RARA SOS2 AKT2 AKT3 NRAS BAD CEBPE RELA TCF7L1 SPI1 CCNA2-1 GLI1 CCNA1 CSF1R TCF7 IKBKB IKBKG CEBPA CHUK CCND1 PIM1 RUNX1T1 RUNX1 NFKB1 IL3 FCGR1A LEF1 KIT MPO TCF7L2 CSF2 BCL2A1 STAT3 PER2 ARAF MYC ITGAM FLT3 JUP OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP5094%HOMO SAPIENS Orexin receptor pathway PRKCB PRKAA1 PLD1 SMAD1 GCG SLC2A4 PIK3R2 SMAD5 PIK3R1 NPY MTOR MAP2K2;MAP2K1 NFE2L2 GRIA1 ARRB1 EIF4EBP1 ARRB2 MAPK1 SLC1A2 IL9 FSHB BMPR1A SGK1-1 GNA11 MAPK3 HCRTR2 CXCL8 RPS6KA1 HCRTR1 EIF4B RPS6 PRKCD TNF FOXO1-1 RPS6KB1 CASP3 CREB1 DAGLA IL10 GNAI1 CCK PRKCA IL1B NPVF CGA HCRT GNAQ PLCD1 MAPK9 HIF1A PRKCE OPRK1 PTPN11 PDK1 MAPK14 LHB NPFFR1 PRKCZ CASP9 VHL PDPK1 POMC TH PRKD1 MAPK8 MAPK7 GNRH1 DYNLT1 IL6 CAMKK2 GHRL GNAS-1 RRAGC SLC2A1 ADIPOQ PDHB LEP BMP7 NOX4 STAT3 CXCL2;CXCL3;CXCL1-1 RUNX2 IL4 STAR DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260810%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV SYNGAP1 HOMER1 GRIN2C RYR2 GRIN2D RPH3A ARC GRIN2A MAPK1 YWHAG CAMK2A MAPK3 SHANK1 CAMK2D GRIN2B CAMK2B GRM1 CYFIP1 CAMK2G FMR1 NRXN2 NRXN1;NRXN3;NRXN2 NRXN3 TJP1 NLGN1 STX1A GRIN1 NLGN3 NLGN2 DLG1 DLG2 DLGAP1 NLGN4X;NLGN4Y KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260810%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy KCNQ4 PRKCE KCNQ5 DAG1 SNAP25 RAB11A BACE1 NEDD4 PRKACA-1 CAMK2A PRRT2 AKAP5 KCNQ2 KCNQ1 KCNQ3 SCN8A SCN4B VAMP2 CALM1 STX1A ANK3 FGF13 RAB1A FGF12 NEDD4L ITPR1 TRAPPC3 SCN2A TRAPPC2;TRAPPC2B GIGYF1 TRAPPC6B FOXP3 IN COVID 19%WIKIPATHWAYS_20260810%WP5063%HOMO SAPIENS FOXP3 in COVID 19 CD28 STAT5A FOXP3 STAT5B IL6 IL2RG CD86 IL2RA IL2RB CD80 IL6ST IL6R STAT3 IL7R IL2 PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260810%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway RHOA SEPTIN2 RAB35 RDX MYL2 AFAP1 KIF23 MSN OCRL EZR ANLN RACGAP1 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260810%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GIP GCG PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260810%WP4224%HOMO SAPIENS Purine metabolism and related disorders PRPS1 GRM5 PPAT AOX1 MOCOS PFAS HPRT1 PAICS ADA RRM2B ADSL ATIC AMPD1 GART APRT IMPDH1 DGUOK ADSS2 ITPA TPMT PNP-1 XDH MAT2A NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260810%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway AKT1S1 ACACA DCAF17 PRKAA1 ATP13A2 TSC2 TSC1 WDR45 C19orf12 GTPBP2 ATG2A ATG4A WIPI1 COASY MTOR WIPI2 FA2H PLA2G6 FTL-1 RPTOR RHEB PIK3C3 STK11 DEPTOR MECP2 RB1CC1 PIK3R4 MLST8 CP ATG3 BECN1 ATG12-1 MAP1LC3A ATG10 ATG13 ATG5 ATG101 ATG7 SPTLC1 ATG16L1 SCP2 ULK1 ATG14 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260810%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer PSAT1 PDHA1 GLUD1;GLUD2 PAICS RPIA PGD PFKL PKM TKT TIGAR FASN ALDOB PGAM1 GLS DLST GAPDH-1 PYCR1 ACLY G6PD PGK1 ACO2 IDH3A ENO1 FH MDH2 HK3 GPI SDHB GOT2-1 TALDO1 SLC2A1 SLC1A5 PDHB SHMT2 SLC16A3 PSPH SUCLG2 LDHA PYCR2 IDH2 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260810%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome ITGB2 ITGA4 CHST6 ITGB1 ITGA6 CHST1 GLI3 HLA-DMB ARNTL CLOCK TP53 EXT1 EXT2 REST CD19 CD4 HBEGF HLA-DRA LGALS3BP PEX16 SPPL2C ACCS SHH ITGA3 C11orf96 CD63 C11orf94 ALKBH3 LARGE2 PEX3 CD53 SLC35C1 SLC25A17 B3GNT7 PRDM11-1 B4GALT4 IGSF8 PHF21A ALX4 TP53I11 SYT13 B4GAT1 TSPAN18 VANGL1 IZUMO1-1 CD151 TIMP1 HLA-DMA LEF1 CD82 NRXN1;NRXN3;NRXN2 MS4A1 NDST1 SDCBP MAPK8IP1 CRY2 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260810%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 APOA2 LPL LCAT APOA1 LIPC APOE VLDLR LDLR LRP1 APOA4 PLTP CETP SCARB1 GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260810%WP2261%HOMO SAPIENS Glioblastoma signaling PRKCG PRKCB RB1 MAP2K3 CDKN1B PIK3CD BRCA1 TSC2 TSC1 CCND2 PIK3R2 PIK3CB PIK3R1 MAP2K2;MAP2K1 BRAF FGFR1 PIK3CA GRB2 KRAS CDKN1A MET MAPK1 AKT1 GAB1 RAF1 CCNE1 MAP2K6 NF1 HRAS MDM2-2 MAPK3 IRS1 PDGFRB PDGFRA E2F1 PIK3CG PRKCD FOXO1-1 CDK6 AKT2 AKT3 NRAS PRKCA CDK4 CDK2 MSH6 TP53 ATM SRC FOXO3 PRKCI PLCG2 PRKCH PLCG1 PRKCQ SPRY2 PRKCZ BRCA2 ERRFI1 PTEN PIK3C2G PIK3C2A PIK3C2B CDKN2B MAP2K4 CDKN2C PDPK1 CDKN2A EGFR CCND1 ERBB3 ERBB2 MAP2K7 MAP2K5 MDM4 CBL FGFR2 FOXO4 IGF1R ARAF EP300 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260810%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease VCAM1 ITGB2 ICAM1 SELE ITGB7 ITGA4 ITGA2 SELPLG ITGB1 MADCAM1 BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260810%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment PIK3CD TP73 YWHAE PIK3CB MTOR MAP2K2;MAP2K1 PIK3CA MKNK1 EIF4EBP1 KRAS ROCK2 MAPK1 AKT1 RAF1 GAB1 EIF4E YWHAG MAP3K5 YWHAH MAPK3 SHC1-1 IRS1 CREB1 IRS2 ROCK1 PARD6A CFL2 STMN1 CFL1 RHOA NTRK2 RAP1B LIMK1 DIAPH1 SH2B2 FOXO3 TCF7L1 PLCG1 CASP9 RTN4R EEF2K TIAM2 PARD3 NPTX2 ARHGDIA RND3 LINGO1 EEF2 DOCK7 WASL CTNNB1 NGFR CDC42 PAK1 BCL2L11 MYC TIAM1 PRKCG PRKCB FADD NFKBIA BCL2 GRB2 YWHAB YWHAQ SMPD1 HRAS APAF1 TRADD PIK3CG PRKCD CASP8 YWHAZ RPS6KB1 RPS6KB2 MAP3K3 SOS1 RAC1 CYCS-1 NRAS PRKCA TRAF6 BAD TP53 BAX SORT1 KIDINS220 PRKCI PRKCH JUN PRKCE FRS2 PTPN11 CRK TCF7 GSK3B PRKCZ MAPK11 IKBKB IKBKG MAP2K4 CHUK PDPK1 PARD6B MAPK8 MAPK7 MAP2K7 MAP2K5 MAP3K1 LEF1 TCF7L2 IQGAP3 MAPKAPK2 BMP7 RAPGEF1 STAT3 BDNF ARHGAP35 NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260810%WP4564%HOMO SAPIENS Neural crest cell migration during development EPHB2 MMP8 PIK3CD PIK3R5 PIK3R3 PIK3CB CDH11 PIK3CA EPHB4 AKT1 PIK3R6 PAK3 PAK2 PAK5 PAK4 PIK3CG PIK3R4 MMP9 ARF1 TRIO FOS BUB1B-PAK6;PAK6 RAC1 AKT2 AKT3 RHOA EPHB6 EPHB1 EPHB3 NGEF NGFR MMP2 PAK1 STAT3 F2RL2 BDNF TIAM1 JUN GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260810%WP5292%HOMO SAPIENS Glycosphingolipid metabolism A3GALT2 NEU3 B4GALT3 B4GALT6 GLA B4GALT5 GALC GBA B3GALT2 GBA2 B3GNT5 A4GALT UGT8 B3GALT1 UGCG NEU4 B4GALT4 ST3GAL5 ARSA GAL3ST1 B4GALNT1 ANGIOGENESIS%WIKIPATHWAYS_20260810%WP1539%HOMO SAPIENS Angiogenesis MMP9 HIF1A TEK PLCG1 TIMP3 MAPK14 VEGFA KDR SMAD1 PDGFB FGF2 FGFR2 ANGPT1 PIK3CA FLT1 ARNT PTK2 MAPK1 SRC AKT1 NOS3 CREBBP PDGFRA TIMP2 EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260810%WP5443%HOMO SAPIENS Effects of MFN2 mutation TUBB3;TUBB6 DYNC2H1 DYNC2I2 CASP3 DYNC2I1 DYNC1H1 KIF1B RABAC1 RAB3A RHOT1 RAB7A MFN2 TRAK1 MAP2 TP53 BAX DYNC1LI2 SYPL1 DYNC1I1 ATAT1 SNCA DCTN1 RAB3B CASP8 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260810%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment TNF CHUK NFKB1 IL6 IKBKB MUC1 RELA NFKBIA IKBKG SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260810%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence PRKCB RB1 GLB1 SMPD3 MTOR CDKN1A GBA SGMS2 MAPK1 UGCG TERT KDSR CERS4 E2F1 SGPP1 DEGS1 CERS2 ASAH1 PRKCA CDK4 CDK2 S1PR1 S1PR2 S1PR5 SPTLC1 SPHK1 RPP38 PLCB1 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome POLR2F SOCS3 IL36A IL36B ARF6 IL36RN IL36G GRB2 POLR1A POLR1B MAPK1 IL1F10 POLR1C POLR1D POLR1F POLR1H GAS6 IL37 MERTK POLR2E RAC1 POLR1E POLR2H POLR2L IL1B IL1A PTK2 IL23A TULP1 CXCL13 PLCG2 IL1RAP LGALS3 CSF1 ANAPC1 IL1RN ZC3H8 ZC3H6 IL6 CHCHD5 ACOXL PSD4 ARL14 CKAP2L POLR1G GATA3 FBLN7 IL1R1 TMEM87B SLC20A1 SOCS1 TTL CSF2 IL1RL2 STAT1 BCL2L11 IL2 MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260810%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 ARCN1 CDKN1A ID2-1 ID1 USP1 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260810%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome ACACB MAPK14 ACACA PRKAA1 MAPK12 MAPK13 MAPK10 MAPK11 G6PC3 MAPK1 G6PC2 MAPK3 ACLY MAPK8 PRKAG1 PRKAG2 PRKAG3 CRP PRKAA2 PRKAB2 PRKAB1 PCK2 G6PC1 MAPK9 SLC27A2 COPPER HOMEOSTASIS%WIKIPATHWAYS_20260810%WP3286%HOMO SAPIENS Copper homeostasis STEAP4 XIAP APC COMMD1 GSK3B MT3 MTF1 MT2A PTEN ADAM10 SP1 MTF2 PIK3CA APP PRNP BACE1 AKT1 MDM2-2 CCS CCND1 SCO1 FOXO1-1 COX17 CASP3 COX11 SLC31A1 STEAP3 ADAM17 TP53 ATP7B ATP7A SLC31A2 ATOX1 ADAM9 MAPT STEAP1 STEAP2 FOXO3 SOD3 SLC11A2 JUN SOD1 SIGNALING LIPIDS%WIKIPATHWAYS_20260810%WP5584%HOMO SAPIENS Signaling lipids PTGS2-2 PLA2G1B ALOX15 ALOX12 LTC4S PRXL2B CYP7B1 HPGD LTA4H CYP2C9;CYP2C19 CYP7A1 PTGDS CBR1-1 PTGES PLA1A FADS2 ALOX5 CYP27A1 GPX4 CYP2B6 EPHX2 TBXAS1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PLCB1 CYP8B1 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260810%WP3676%HOMO SAPIENS BDNF TrkB signaling PLCG1 TSC2 HOMER1 TSC1 ARC MTOR MAP2K2;MAP2K1 TRPC6 TRPC3 BRAF MKNK1 EIF4EBP1 GRB2 KRAS MAPK1 AKT1 GAB1 DLG4 EEF2K RHEB HRAS SHC1-1 RPS6KA1 PIK3CG GAB2 RPS6KB1 ADCY1 CREB1 SOS1 NRAS NTRK2 GRIN1 BDNF HISTONE MODIFICATIONS%WIKIPATHWAYS_20260810%WP2369%HOMO SAPIENS Histone modifications SETD9 SMYD5 SETD6 KMT2B DOT1L PRDM2 SMYD1 SMYD4 KMT5B KMT5A SMYD3 EHMT2 KMT5C SETD5 SETD1B AEBP2 SETD1A SETMAR EZH1 ASH1L SETBP1 KMT2C SET-1 EZH2 SUV39H2 SUV39H1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SETDB1 H4-16 H4C1 H4C6 SETD7 EED SETD2 NSD1 EHMT1 SETD4 KMT2E SMYD2-1 H3-3A KMT2D KMT2A SETD3 T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260810%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection MAP2K2;MAP2K1 IL5 PIK3CA NFKBIA CHP1 GRB2 AHSA1 AKT1 RAF1 MAPK3 TNF FOS SOS1 PDCD1 IL10 CDK4 CD3D GRAP2 CTLA4 ZAP70 LCK LCP2 CARD11 BCL10 MALT1 FYN MAPK9 JUN PLCG1 ICOS PDK1 CD4 PTPRC PRKCQ CD28 GSK3B DAG1 LAT NCK1 PTPN6 IKBKB IKBKG MAP3K7 CHUK CD8A ITK MAP2K7 CBL NFATC2 IFNG NFKB1 CALM1 MAP3K14 CSF2 MAP3K8 DLG1 PAK1 RRAS IL2 IL4 CD40LG IL2 SIGNALING%WIKIPATHWAYS_20260810%WP49%HOMO SAPIENS IL2 signaling PTPN11 SOCS3 STAT5A STAT5B IL2RG PIK3R1 MAP2K2;MAP2K1 IL2RA IL2RB GRB2 MAPK1 NMI AKT1 RAF1 JAK3 HRAS MAPK3 SHC1-1 RPS6 GAB2 RPS6KB1 RPS6KB2 CBL SYK SOS1 JAK1 STAT1 LCK STAT3 CRKL CISH MAPT FOXO3 IL2 PTK2B FYN INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260810%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260810%WP5146%HOMO SAPIENS Lung pathology of COVID 19 TNF CGAS NFKB1 IL6 IRF3 IL1B STING1 MAVS CXCL10 TBK1 CCL13;CCL2 CXCL11 TLR8 CSF2 TLR7 IFIH1 CXCL9 IL18 TLR3 DDX58 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation SPI1 TCF4 CDKN1B POU2F2 CCND3 CCND2 ID3 MEF2B;BORCS8-MEF2B CDKN1A EZH2 SPIB TLR10 LOC102723996;ICOSLG POU2AF1 IRF8 TNFRSF13C IRF4 CDKN2A CD40 MEF2C E2F1 LYN BCL6 BCR SYK NFKB1 IL6 TLR1 IL21R SLAMF1 TLR9 STAT6 TLR8 TLR7 BCL2L1 IL4R TLR6 TLR5 STAT3 TLR4 TLR3 TLR2 MYC CD79B CD79A T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260810%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer PDGFD PDGFC ENTPD1 TGFB2 VEGFB VEGFC VEGFD FASLG PVR VDR VSIR HAVCR2 B2M CD40 CD226 CCL17 VTCN1 IL13 TIGIT CD276 CCL22 TNFRSF9 FAP PGF TNFSF9 PDCD1 IL10 FAS CTLA4 PDCD1LG2 TNFRSF4 ICOS CD28 LGALS3 LGALS9C;LGALS9;LGALS9B PDGFB PDGFA NT5E SHH CXCL12 ARG1 TGFB3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TGFB1 LGALS1 VEGFA TNFSF4 IL6 CD86 CXCR4 CD80 IDO1 IL4 CD40LG CD274 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5365%HOMO SAPIENS 4p16 3 copy number variation PLCG1 FRS2 FGF2 PIK3R1 GRB2 CLTCL1 MAPK1 GAB1 UBE2J2 NELFA NAT8L NELFE MAPK3 NSD2 TMEM129 FAM53A CBL CKAP5 LETM1 TACC3 C4orf48 SOS1 NELFB BCS1L SLBP ERI1 POLN FGFR3 H3-3A NELFCD CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260810%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO5 FMO4 FMO3 FMO1 FMO2 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260810%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection EIF2AK3 PPP1R3B PPP1CA PPP1R12B ATF4 PPP1R7 PPP1R12A ERN1 PPP1R12C DDIT3 ATF6 EIF2S1 BCL2 EIF2AK2 MBTPS1 MAPK8 PPP1R14A PPP1R3A PPP1R9A MAP1LC3A MBTPS2 PPP1R15B PPP1R14C PPP1R13B PPP1R11 PPP1R8;STX12 PPP1R2-1 PPP1R16B PPP1CB PPP1R14B PPP1R16A PPP1CC PPP1R3G PPP1R3F PPP1R3E PPP1R1C PPP1R3D PPP1R14D PPP1R10 PPP1R1A PPP1R15A PPP1R3C XBP1 EIF2AK1 HSPA5 PPP1R1B FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260810%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor TGFB1 COL1A1 CCN2 TGFB2 MAPK10 SMAD2;SMAD3 RHO FN1 ENPP2 STAT3 TGFB3 ACTA2 MAPK8 MAPK9 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260810%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 ITGB2 ITGAX IFIT2 STAT5A PAX5 IRF8 IRF4 ZEB2 CD40 MFGE8 BCL6 TNF FOXO1-1 BCR SYK C3-1 CRP PDCD1 IL10 ISG15 SELL TLR7 BACH2 IL21 TMSB10 FCRL5 CXCL13 BLNK TLR4 CD1D CXCR5 SLAMF7 CCL21 AICDA CD79A CCL19 CD19 ICOS TNFSF13B CR2 PTPRC CD22 PRDM1 IFITM3;IFITM2;IFITM1 CXCL12 GPR183 LOC102723996;ICOSLG LOC110384692;C4A;C4B_2;C4B BTLA MAF CD69 IFNG CR1L;CR1 ETS1 IL6 TBX21 CD82 MS4A1 SH2D1A CXCR4 HSPA8 CCR7 CD80 IL12A IFNAR2 IL2 IL4 CD40LG PTCRA XBP1 EBI3 ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260810%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer TP53 CCNE2 GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260810%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways MRE11 GTF2H1 GTF2H3 BRCA1 POLD2 GTF2H4 ERCC3 CHEK1 MNAT1 NBN RFC1 FANCD2 CUL4B PRKDC MSH3 PCNA RPA2 RAD52 RAD50 FEN1 RAD51 POLB ATM RAP1A ATR TERF2 POLH ERCC5;BIVM-ERCC5 MSH2 XPC BRCA2 POLK MLH1 MGMT CENPS-CORT;CORT;CENPS FAAP24 BRIP1 LOC105377022;FANCB USP1 FAAP100 FANCI FANCM CENPX FANCL REV1 FANCA FANCC FANCE PALB2 FANCG FANCF RAD51C HMGB1-1 ERCC4 RBX1 CETN2 ERCC1 XPA RAD23A ERCC8 ERCC6 RAD23B TDG POLE MPG OGG1 PNKP UNG NTHL1 MUTYH MBD4 SMUG1 ERCC2 NEIL3 XRCC1 CUL4A DDB2 POLD3 POLD4 DDB1 RFC5 RAD54B RFC3 RFC4 LIG1 RFC2 RPA1 MSH6 EXO1 PARP2 RPA3 PMS2 POLE4 POLE2 POLE3 WDR48 REV3L POLI APEX2 NEIL2 APEX1 FAN1 PARP1 WRN POLD1 XRCC6 DCLRE1C XRCC4 CDK7 POLM XRCC5 LIG4 POLL NHEJ1 LIG3 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260810%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC51A ABCC2 SLC51B ABCC4 SLC10A2 ABCC3 ABCB11 SLC10A1 ABCB1 FABP6 IL9 SIGNALING%WIKIPATHWAYS_20260810%WP22%HOMO SAPIENS IL9 signaling STAT5A STAT5B CDK9 PIK3R2 IL2RG PIK3R1 IL9R MAP2K2;MAP2K1 GRB2 MAPK1 JAK1 IL9 STAT1 STAT3 JAK3 MAPK3 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260810%WP4316%HOMO SAPIENS miRNA degrading enzymes XRN1 PNPT1 EXOSC4 ALSTROM SYNDROME%WIKIPATHWAYS_20260810%WP5202%HOMO SAPIENS Alstrom syndrome BLOC1S4 VCPIP1 BLOC1S6 ALMS1 BLOC1S1 STX5 SNAPIN PIFO RFX2 TFDP2 DTNBP1 RFX3 E2F4-1 RFX1 TUBG1 ARMCX5-GPRASP2;GPRASP2 NSFL1C RILPL1 GPR161 DNM3 MYO5B ACTN4 PTCH1 HSPB11 IFT74 IFT81 CEP19 IFT27 IFT172 VCP-1 CEP192 RABL2A;RABL2B SMO ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260810%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma NR3C1 PRKACA-1 ADRB2 PRKACB-1 ADCY4 ADCY3 ADCY2 ADCY1 CREB1 PRKAR1B ADCY8 ADCY7 ADCY6 PRKAR1A ADCY5 MYL4 GNAS-1 MYL1 PRKAR2A PLCB3 MYL2 PLCB4 MYL3 ADCY9 PLCB1 PLCB2 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260810%WP558%HOMO SAPIENS Complement and coagulation cascades CFD C1QB C1S CFB C1R C2 C6 C8G C7 C9 MASP2 MASP1 CD55 C1QC CLTC F2R C3-1 FGB F10 SERPINF2 SERPINE1 PLAT PLG KNG1 F3 BDKRB1 F5 F7 F8 F12 F9 SERPING1 KLKB1 PLAU PROS1 CLU VWF SERPINA5 C3AR1 CR2 F2 CPB2 SERPINC1 CFI C5AR1 TFPI LMAN1 SERPINA1 SERPIND1 PROC CFH-3 F13B PLAUR LOC110384692;C4A;C4B_2;C4B THBD CR1L;CR1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260810%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PDK1 PIK3CD PIK3R5 PIK3R3 TSC2 GSK3B TSC1 PIK3R2 PIK3CB PIK3R1 PHLPP1 MTOR PIK3C2G PIK3CA PIK3C2A IKBKG PARP3 PIK3C2B AKT1 PIK3R6 RPTOR MAPKAP1 STK11 PARP1 PIK3CG RICTOR PIK3R4 MLST8 FOXO1-1 AKT2 AKT3 SIRT1 PARP2 ATM POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260810%WP2571%HOMO SAPIENS Polycystic kidney disease pathway PKD1 FZD5 FZD4 PRKAA1 FZD8 TSC2 TSC1 SLC12A2 MTOR WNT8A MAP2K2;MAP2K1 BRAF FLT1 VEGFB KRAS WNT9A RHEB WNT8B HRAS GNA11 MAPK3 RPS6KA1 PKD2 STK11 TNF SSTR2 KDR FOS ADCY6 GNAI3 GNAI1 NRAS PRKAA2 GNAI2 SRC PDE1A GNAQ FZD10 KCNN4 PLCG2 JUN WNT5B SFRP4 WNT2B GSK3B WNT6 DVL1 IKBKB DVL2 DVL3 WNT3 WNT4 FZD1 WNT10B WNT10A FZD3 FZD2 WNT1 FZD7 WNT2 FZD6 FZD9 WNT3A CCND1 WNT7B ERBB2 WNT5A PRKAG1 PRKAG2 WNT9B EGF PRKAG3 IGF1 WNT16 CFTR PRKAB2 PRKAB1 GNAS-1 WNT11 WNT7A CTNNB1 IGF1R MYC NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260810%WP259%HOMO SAPIENS Nifedipine activity BDKRB2 MAPK1 KDR CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PTK2B MAP2K2;MAP2K1 PCNA SOD1 FERROPTOSIS%WIKIPATHWAYS_20260810%WP4313%HOMO SAPIENS Ferroptosis SLC39A8 CTH CYBB VDAC3 GCLM AIFM2 MAP1LC3C GCLC TXNRD1 ACSL6 ACSL5 FTL-1 HSPB1 ACSL4 PRNP HMOX1 ACSL1 SLC7A11 ATG5 SLC3A2 TP53 SAT1 SLC11A2 FTH1 ALOX15 NOX1 GCH1 COQ2 SLC38A1 CISD1 SAT2 CHMP6 CHMP5 DPP4 FTMT FDFT1 PCBP1 PHKG2 LPCAT3 BACH1 CP MAP1LC3B2;MAP1LC3B-1 MAP1LC3A ACSL3 CBS;CBSL VDAC2-1 PCBP2 TF GPX4 STEAP3 TFRC ATG7 NCOA4 SLC39A14 IREB2 SLC40A1 SLC1A5 HMGCR NOX4 POR GSS VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260810%WP3871%HOMO SAPIENS Valproic acid pathway ABAT CYP2B6 ACADSB HADHA CYP2A13;CYP2A6;CYP2A7-1 HSD17B10 CYP2C9;CYP2C19 EHHADH-1 ACSM1 HDAC1 IVD HADHB-1 NRF2 PATHWAY%WIKIPATHWAYS_20260810%WP2884%HOMO SAPIENS NRF2 pathway DNAJB1 TXNRD1 SLC6A13 CES5A CES2 CES1 SLC6A6 PPARD HMOX1 SLC6A8 BLVRB SLC7A11 MAFG ABCC4 SLC5A5 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HSPA1A;HSPA1B FGF13 HSP90AB1 KEAP1 PTGR1-1 FTH1 HBEGF SLC6A18 SLC2A12 SLC6A17 SLC6A16 SLC6A15 PDGFB SERPINA1 SLC6A14 SLC5A6 SLC5A7 SLC5A8 SLC5A9 CES3 EPHA3 TGFA MGST3 SLC6A1 HSP90AA1 MGST2 SLC5A2 SLC6A20 SLC5A3 SLC5A4 PRDX6 SLC6A5 SLC6A7 HGF SLC6A9 SLC6A2 SLC6A3 GSTP1 SLC2A11 SLC6A11 SLC2A10 SLC2A13 SLC39A11 PRDX1 SLC39A10 GSTM3 SLC39A13 SLC39A12 SLC39A14 EPHA2 SLC6A4 CBR3 GSTA4 SLC39A9 SOD3 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SQSTM1 CYP2A13;CYP2A6;CYP2A7-1 SLC39A1 GCLM SLC39A4 SLC39A3 SLC5A1-1 TGFB2 SLC2A4 ABCC3 PGD ALDH3A1 ABCC5 NQO1 GCLC NFE2L2 FTL-1 GSTA3;GSTA1 SLC2A9 MAFF SRXN1 SLC2A5 SLC2A6 SLC2A7 SLC2A8 G6PD GSTT2B;GSTT2 SLC5A11 TGFBR2 SLC5A12 SLC5A10 RXRA TXNRD3 TXN GSTM1;GSTM2-1 GSTA3;GSTA5;GSTA1;GSTA2 SLC2A2 SLC6A19 GGT1 CBR1-1 NRG1 GSR TGFB1 ABCC2 UGT1A1;UGT1A6 AGER EGR1 SLC2A1 GSTM4 ME1 TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260810%WP1471%HOMO SAPIENS Target of rapamycin signaling AKT1S1 ULK2 PRKAA1 TSC2 TSC1 IDI1 MTOR EIF4EBP1 AKT1 RPTOR PRR5 RHEB DDIT4L MAPKAP1 ULK3 RICTOR MLST8 RPS6KB1 PRKAG1 FKBP1A PRKAG2 PRKAG3 RAC1 PRKAA2 PRKCA PRKAB2 PRR5L PRKAB1 RRAGA RRAGC RRAGB RRAGD HMGCR CDC42 DDIT4 ULK1 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260810%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer FOXO1-1 TNF CCL4L2;CCL4L1;CCL4 CCL5 CCL3L1;CCL3L3;CCL3;CCL18 BMI1 IFNG FCGR3A;FCGR3B GZMH;GZMB-1 KLRC4-KLRK1;KLRK1 NCR1-1 CCL1 ADAM10 GATA2 ADAM17 CCL13;CCL2 CSF2 PVR CD226 PRF1 TIGIT MYC CD96 NCR3LG1-1 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260810%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MEF2B;BORCS8-MEF2B MEF2A KLF4 MEF2D CCND2 CAMK2D MEF2C SRF NKX2-5 MYOCD ELK1 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260810%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation AS3MT ATP1A1 COA3 VDAC1 GSTO1 UQCRFS1 CAT SDHA SOD1 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260810%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism PTGS2-2 EPHX2 TBXAS1 PTGS1 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260810%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260810%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain PDK1 MAP2K3 TRIO NFKB1 RAC1 YAP1-1 AMOT MTOR MAP2K2;MAP2K1 PIK3CA RHOA MAPK1 AKT1 MAP2K4 RAF1 GNAQ MAP2K6 MAPK3 MAP2K7 MAP2K5 GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260810%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs PC GK PFKL TPI1 SDS PKLR GPD1 ALDOB PGAM1 PNPLA2 GAPDH-1 FBP1 LIPE PGK1 ENO1 PCK1 KHK ALDOA AGXT GPD2 AQP9 MGLL GPI GLYCTK HK1 GRHPR AKR1A1 LOC100509620;LOC112267859;AQP7 G6PC1 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260810%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway SQLE HMGCS1-1 LSS DHCR7 IDI1 MVK FDFT1 HMGCR MSMO1 FDPS MVD NSDHL PMVK CYP51A1 SC5D NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260810%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan QPRT KMO TDO2 KYNU AFMID NMNAT1 NADSYN1 HAAO COPPER METABOLISM%WIKIPATHWAYS_20260810%WP5189%HOMO SAPIENS Copper metabolism ATP7B ATP7A SLC31A1 SLC11A2 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260810%WP3298%HOMO SAPIENS Melatonin metabolism and effects CRY1 CSNK1D IRAK1 GSK3B APOE MAOA ECE1 ASMT EDN1 CYP2C9;CYP2C19 AANAT CAMK2A ADRB1 TPTEP2-CSNK1E;CSNK1E ACHE CYP1A2 FOXO1-1 ARNTL CYP2D6;LOC107987479;LOC107987478-1 NFKB1 CALM1 CLOCK SIRT1 PRKCA TRAF6 MAP2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 PER2 MTNR1A PER1 MTNR1B CYP1A1 CYP1B1 CRY2 MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260810%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation SIX4 STRADB PTBP1 PRKAA1 CTDSP1 STK11 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260810%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies TNF HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CCL20 IL17F IL23R IL1B CCR6 IL12B IL17RC IL23A IL17A IL22 STAT3 JAK2 CXCL2;CXCL3;CXCL1-1 CXCL8 TYK2 IL12RB1 ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2853%HOMO SAPIENS Endoderm differentiation PBX1 TCF4 MAP2K3 ACACA ZFHX4 SESN1 TAF5 WNT8A LHX1 GLI2 DUSP4 FOXA1 BMPR1A SOX21 SOX17 CUL4B CEP250 DIP2A SMAD4 EOMES WDHD1 ZNF281 FOXH1 FOXO1-1 EMSY PIAS1 WDFY2 HPRT1 BCORL1 TOX PAX3 MBTD1 DUSP2 EPB41L5 UBR5 ATP8B2 PBX3 GDF3 TOX3 TRERF1 EXT1 NABP2 TRIM71 SIAH2 RARG NCAPG2 PHF6 ELAVL1 ZIC3 TRIM5 TCF7L1 C1QBP DNMT3B JARID2 NOTCH1 SLC2A12 TET1 PARP8 DDAH1 AEBP2 FOXA2 MTF2 HNF1B AHDC1 APP ASCC3 ZNF462 ELP4 GRHL2 NR3C1 RGS10 CER1 MIXL1 NOG DKK1 WWC1 TBX21 NODAL MAD2L2 LAMC1 OTX2 CTNNB1 CAND1 HOXC11 VAV3 NAA15 PTHLH NME1 GATA4 SFRP1 SOX7 PABPC1;PABPC3 APC CTBP2 NKX2-1 TCF7 POU5F1;POU5F1B WNT3 EZH2 NANOG;NANOGP8 SOX2 TGFB1 SFMBT1 CDYL RFX7 ZBTB17 RAB38 CTR9 PRDM14 RTF1 SMAD2;SMAD3 BPTF PLCH1 LEF1 HOXA1 FOXN3 DAB2 SP4 CRTC1 GATA6 PAF1 TAF4B ONECUT1 ELK4 NLK CDC73 HHEX DUSP5 PAX9 BTAF1 LEO1 KDM4A STAT1 BMP7 LRPPRC TNRC6C CEBPZ MACROPHAGE MARKERS%WIKIPATHWAYS_20260810%WP4146%HOMO SAPIENS Macrophage markers F3 CD74 LYZ-1 CD163 CD14 CD83 CD68 CD86 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260810%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling MAPK14 ABCC2 GSTP1 GCLM ABCC4 FOS MAPK12 MAPK13 ABCC3 MAPK11 NQO1 ABCC6 GCLC NFE2L2 SRXN1 ABCG2 EPHX1 CES1 MAPK8 NQO2 HMOX1 JUN KEAP1 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260810%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYB5R4 CYP11B1;CYP11B2 CYB5R3 CYP2A13;CYP2A6;CYP2A7-1 CYP4V2 CYP2J2-1 CYP7B1 CYP2C9;CYP2C19 CYP7A1 CYP46A1 CYP2S1 CYP2F1 CYP2E1 CYP4B1 CYP51A1 CYP1A2 CYP27A1 CYP2W1 CYP27B1 CYP2D6;LOC107987479;LOC107987478-1 CYP24A1 CYP2R1 CYP20A1 CYP26B1 CYP26A1 CYP2B6 CYP39A1 CYP2U1 CYB5A CYP4F22 CYP19A1 CYP4X1 CYP17A1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2C18-1 CYP1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP8B1 POR CYP1B1 CYP27C1 CYB5R2 CYB5R1 CYP11A1 HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260810%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells TNF PLCG1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SYK PTPN2 PRKCQ IFNG RAC1 LAT NLRP7;NLRP2 PTPN6 PRKCA ELF3 CSF2 LCP2 VAV1 ITPR1 TYROBP FYN OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260810%WP3941%HOMO SAPIENS Oxidative damage response C3AR1 TNK2 CDKN1C BAG4 CR2 TDP2 CDKN1B TRAF1 C1QB C5AR1 C5 C1S MAPK13 NFKBIE C1R MAPK10 CASP9 C2 TNFRSF1B BCL2 CDKN1A BAK1 C1QC MAP2K4 LOC110384692;C4A;C4B_2;C4B APAF1 PCNA TNF MAP3K1 TRAF2 GADD45A CASP3 NFKB1 CYCS-1 TRAF3 TRAF6 MAP3K9 BAD CDC42 APOPTOSIS%WIKIPATHWAYS_20260810%WP254%HOMO SAPIENS Apoptosis BIRC3 HELLS HRK SCAF11 TRAF1 TNFRSF25 TNFRSF21 TP73 RIPK1 FADD PIK3R1 TNFRSF1B BOK NFKBIA BCL2 FASLG AKT1 IRF4 CASP10 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MDM2-2 APAF1 TRADD CASP8 PMAIP1 IGF2 TNF TRAF2 CASP3 BIRC5 IRF2 IRF3 CYCS-1 TRAF3 BID BAD IRF7 TP53 FAS NFKBIB BAX IRF5 LTA PRF1 CASP6 CASP2 RELA JUN TNFSF10 XIAP MCL1 NFKBIE MAPK10 BNIP3L CASP9 IKBKB CASP7 CASP1 IKBKG CRADD BAK1 MAP2K4 CHUK CDKN2A TNFRSF1A CASP5;CASP4 TP63 IRF6 MAP3K1 IGF1 NFKB1 GZMH;GZMB-1 IRF1 DIABLO-1 DFFB DFFA BCL2L1 BBC3 IGF1R BCL2L11 CFLAR MYC BIRC2 BCL2L2 ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP138%HOMO SAPIENS Androgen receptor signaling RB1 STUB1 BRCA1 RNF14 EFCAB6 NR0B2 PIAS4 PIK3R2 PIAS2 HDAC1 SIN3A ZNF318 PIK3R1 FKBP4 RNF6 RNF4 CARM1 BAG1 PATZ1 DSTN ROCK2 AKT1 RACK1 CCNE1 FHL2 KAT2B TGIF1-1 MDM2-2 CREBBP NR2C2 SMAD4 DAXX NCOA3 FOXO1-1 ETV5 PIAS1 CREB1 SMIM40 RAC1 ROCK1 SIRT1 RHOA PTK2 RAD9A RHOB SRC ZMIZ1 RELA NCOA1 JUN UBE2I PSMC3IP GSK3B PTEN SP1 PIAS3 NCOA2 EGFR KDM1A CCND1 NCOR1 RLN2;RLN1 AR CAV1 KAT5 TLE5 LIMK2 BUB1B-PAK6;PAK6 SUMO1 SMAD2;SMAD3 PARK7 SMARCE1 PRDX1 UBE3A TGFB1I1 NCOA4 RAN CTNNB1 CALR-1 NCOR2 CDC42 FLNA STAT3 RUNX2 EP300 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260810%WP45%HOMO SAPIENS G1 to S cell cycle control RB1 CDKN1B POLE CCND3 E2F3 CCND2 MNAT1 CDKN1A CDC25A CCNE2 MYT1 CCNE1 MDM2-2 PRIM2 PCNA E2F1 PRIM1 MCM7 ORC5 GADD45A CREB3 CREB1 ORC4 RPA2 ORC6 ORC1 ORC3 ORC2 ATF6B CDK6 MCM3 CDK4 MCM5 RPA1 CDK2 MCM6 CDK1 RPA3 TP53 ATM POLA2 CCNG2 CDC45 POLE2 CDKN1C CCNA1 MCM4 TFDP1 TFDP2 E2F2 CDKN2D CDKN2B CDKN2C WEE1 CDKN2A CCND1 CDK7 CCNB1 MCM2 CREB3L3 CCNH CREB3L4 MYC CREB3L1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260810%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation HADHA ACSL3 PECR ACADL ECI1 ACSL4 SLC25A20 ACADVL ACSF2 ACADS EHHADH-1 HADH SCP2 ACADM CPT2 CPT1A ACSL1 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260810%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 APOA2 LPL LCAT PCSK9 APOA1 USF1 LIPC LDLRAP1 APOB LDLR APOA4 PLTP GPIHBP1 EPHX2 GHR CETP VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260810%WP1533%HOMO SAPIENS Vitamin B12 metabolism HBA2;HBA1 CTH MTR-1 NFKB2 MTHFR MCEE MAT1A TNF ICAM1 CRP FGB FGA LRP2 IL1B SERPINA3 FGG ALB SERPINE1 PLAT SAA2;SAA1 SAA2-SAA4;SAA4 PLG CCL13;CCL2 F7 MTRR CUBN CBLIF ABCA1 MMAB TCN2 SCARB1 RELA TCN1 MMUT CCL5 F2 APOA1 APOE APOB LDLR INS;INS-IGF2 SOD2 IFNG NFKB1 CBS;CBSL IL6 MPO SHMT2 INSR SOD3 HBD;HBB SOD1 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260810%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer RB1 NDRG1 MRE11 CDKN1B DOCK1 BRCA1 TSC2 TSC1 CHEK2 CHEK1 MTOR MAP2K2;MAP2K1 PIK3CA EIF4EBP1 CDC25A MAPK1 AKT1 FOXA1 RAF1 GAB1 SPINK1 PRKDC MDM2-2 MAPK3 E2F1 RICTOR ABCC4 RAD50 SPRY1 CDK4 CDK2 CDK1 ELK1 RAP1B ATM RAP1A ATR CDC25B BLM SMARCA4 MSH2 NOXA1 SPRY2 CASP9 SP1 ETV4 CDKN2B CDKN2A CCND1 HGF ERG KLK3;KLK2 PAK1 ARID1A MYC RASA1 FKBP5 PLK1 BCL2 EIF4E1B GRB2 CDKN1A RPTOR RHEB BARD1 HRAS CASP8 CASP3 FOS SOS1 MSH6 BAD TP53 BAX PTK2B JUN ACTL6A PTPN11 MAPK14 CRK PXN HSD17B1 HSD17B2 HSD17B4 F13B PTEN HSD17B7 CPN1 MAP4K1 MAPK8 AR SMARCD1 SMARCD2 SMARCD3 SMAD2;SMAD3 ATF1 SMARCC1 SMARCC2 ARID1B JAK1 ACTL6B STAT1 MMP1 RAPGEF1 HSD17B3 STAT3 CRKL CYP17A1 HSD3B1;HSD3B2 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260810%WP1584%HOMO SAPIENS Type II diabetes mellitus TNF PDX1 MAFA PIK3R5 PHKA2 SLC2A4 PRKCZ GK MTOR IKBKB SURF1 INS;INS-IGF2 MAPK1 ADIPOQ KCNJ11 SOCS4 INSR IRS1 CACNA1A SLC2A2 MAPK8 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260810%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity NR1I3 ABCB11 ABCC3 RARB NR1H4 ABCB4 CYP2C9;CYP2C19 CYP7A1 VDR NR1I2 ABCD2 ABCG5 ABCD3 PPARA PPARD ABCB1 CYP2E1 CYP4B1 CYP1A2 CYP27B1 ABCC2 NR1H3 CYP24A1 RARA ABCG1 PPARG CYP26A1 CYP2B6 RARG CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCA1 CYP8B1 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation TNF RB1 TRAF2 ATG13 GABARAPL2 ATG101 PTK2 TP53 ATG16L1 GABARAP WDR45B MAP3K5 ULK1 PTK2B RB1CC1 PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260810%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways OAT PYCR1 PRODH;LOC102724788 PEPD ALDH4A1 OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260810%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid PTGS2-2 CYP2C9;CYP2C19 PTGS1 GPX4 ALOX15 EPHX3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ALOX12B ALOXE3 CYP1A2 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260810%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders HADHA ACSL3 PECR HADHB-1 ACADL ECI1 ACSL4 SLC25A20 ACADVL ACSF2 ACADS EHHADH-1 HADH SCP2 ACADM CPT2 SLC22A5 CPT1A ACSL1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260810%WP51%HOMO SAPIENS Regulation of actin cytoskeleton CYFIP2 PIK3CD DOCK1 PIK3R3 ARPC5 BCAR1 PIK3R2 RRAS2 EZR PIK3CB CHRM4 PIK3R1 MRAS CHRM5 FGFR1 MAP2K2;MAP2K1 PIK3CA KRAS ROCK2 MAPK1 RAF1 CHRM1 FGF3 MAPK3 PDGFRB FGF6 PDGFRA ACTG1 WASF1-1 FGF9 MYH10 SSH2 SSH3 F2R SSH1 FGF23 VIL1 DIAPH3 PIP5KL1 GIT1 ROCK1 FGD1 WASF2 BAIAP2 ABI2 CFL2 FGF20 FGF22 CFL1 FGF17 FGF16 RHOA MYL1 PTK2 LIMK1 DIAPH1 FGF14 MYL3 FGF18 FGF13 FGF12 FGF11 FGF7 RDX PDGFB PDGFA FGF1 FGF4 ARHGEF6 FGF8 APC2 EGFR NCKAP1 VCL RASSF7 CSK BUB1B-PAK6;PAK6 FGF10 ITGA1 FN1 ACTB-1 CDC42 PAK1 FGFR4 VAV1 FGFR3 PIK3R5 PPP1R12A SLC9A1 CD14 BRAF FGF5 PAK3 PAK2 PAK5 PAK4 CHRM3 PIK3CG GSN MSN SOS1 RAC1 SOS2 PFN1 NRAS BDKRB2 BDKRB1 MAPK6 MAPK4 GNA13 GNA12 MOS RAC3 ARHGEF1 ARHGEF7 ARHGEF4 F2 ENAH CRK APC PIP5K1A PXN FGF2 WAS IQGAP1 PIK3C2G PIK3C2A CHRM2 PIK3C2B PIP4K2A PIP4K2B PIP4K2C FGF21 PIK3C3 PIK3R4 EGF MYLK PIP5K1B ACTN1 PIP5K1C FGFR2 RRAS FGF19 ARHGAP35 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP5414%HOMO SAPIENS IDO metabolic pathway TNF KMO TDO2 IFNG KYNU IDO2 IDO1 KYAT3 AADAT KYAT1 GOT2-1 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260810%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome TAOK2 MAP2K3 SPN HDAC3 EZR PARP4 CDIPT TBX6 MAP2K6 MAPK3 HIRA PCNA CASP8 TRAF2 ALDOA MSN DOC2A PAGR1 PPP4R1 PPP4R2 TRAF6 PPP4R4 CCT3 CCT2 TP53 KIF22 TLCD3B ASPHD1 TCP1 KCTD13 TMEM219 ZG16 PPP4R3A INO80E PPP4R3B MVP GDPD3 SEZ6L2 PPP2R1A CORO1A PPP4C CCT8 CCT7 CCT5 PPP2R5D CCT4 IGBP1 C16orf92 C16orf54 CCT6A YPEL3 IGFBP3 PTEN ESR1 KMT2C NR3C1 PRRT2 CCDC6 PPP2CB;PPP2CA NFKB1 BPTF PPARG MAZ CCT6B HIRIP3 UNC13B QPRT SIAH1 UNC13A PAXIP1 REL KMT2D GLUCURONIDATION%WIKIPATHWAYS_20260810%WP698%HOMO SAPIENS Glucuronidation PGM1 UGT1A1;UGT1A6 UGP2 UGT2A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PGM5 HK1 PGM2 UGDH PGM3 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260810%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein PCSK1 GNAQ SLC5A1-1 GCG SLC2A2 HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260810%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma BIRC3 PTGS2-2 BRCA1 GRB2 CDKN1A FASLG AKT1 RRM2-1 HNF1A MAPK3 CXCL8 SMAD4 CASP3 BIRC5 SOS1 RAC1 TP53 JUN HIF1A PTPN11 MAPK14 TGFBR1-1 CASP9 CASP7 E2F2 CXCR1 UCHL1 NOS2 IL6R CCND1 MAPK8 TGFB1 VEGFA NFKB1 CD44 IL6 LEF1 SMAD2;SMAD3 MYOF JAK1 BCL2L1 PODXL MMP1 COL4A2 STAT3 CTTN FRZB MYC VAV2 SLEEP REGULATION%WIKIPATHWAYS_20260810%WP3591%HOMO SAPIENS Sleep regulation DRD1 DRD3 OXTR CACNA1I BTBD9 AHCY MRGPRX3;MRGPRX4;MRGPRX1;MRGPRX2-3 PTGDR HTR2A CRH ADA GRIN2A SLC29A1 PTGDS OXT-1 DRD2 IL18 TH CHRNB2 HCRTR2 ADORA1 HCRTR1 CST3 NPAS2 NPS FOS IL6 ADORA2A GHRH GHRL NPY2R NLGN1 MTNR1B DLAT STAR UTS2R HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260810%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 CUL2 ELOC-1 RBX1 ELOB NAE1 ZYG11B CBFB UBA3 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260810%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death ATG3 ULK2 BECN1 ATG12-1 ATG10 MAP1LC3A TSC2 VMP1 TSC1 UVRAG AMBRA1 ATG4A ATG5 SH3GLB1 INS;INS-IGF2 ATG7 ATG9B BCL2 ATG16L1 INSR ULK1 ATG14 CHAF1A FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260810%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H2AZ2;H2AZ1 H2AJ BCOR RNF2 SUZ12 KDM2B PCGF1 EED MACROH2A2 MAPK1 EZH2 MACROH2A1 DUSP6 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MAPK3 H2AB2;H2AB3;H2AB1 H3-3A BCL6 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260810%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP2A13;CYP2A6;CYP2A7-1 XDH CYP1A2 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260810%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex LBP CD4 HLA-DRA CRP CD247 IL6 CD3G CD3E PRG3 CD2 NKRF HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ZAP70 IGLL5;IGLL1 LCK CD8A CXCL8 CD8B;CD8B2 MMP25 FYN FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260810%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 MTTP APOA2 LPL LCAT APOA1 LIPC APOC2 LDLR LRP1 SEL1L APOA4 APOA5 FAS LMF1 ACSS1 PLTP GCK GPIHBP1 PDIA2 CETP GCKR DGAT2 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260810%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis FZD1 NEUROD1 NEUROG2 WNT7A FZD3 WNT3A PROX1 CCND1 LRP6 WNT3 WNT5A MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis CYP11B1;CYP11B2 CYP21A2 SRD5A2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HSD11B1 HSD11B2 SRD5A1 AKR1D1 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260810%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts CSGALNACT1 HS2ST1 B3GAT3 XYLT2 XYLT1 CHSY1-1 EXTL3 HS3ST3B1 CHST7 CHPF EXTL2 EXTL1 DSE CHST15 CHST1 CHSY3 CHPF2 B3GAT2 GLCE CHST3 B3GAT1 CSGALNACT2 HS3ST2 UST B3GALT6 HS3ST1 HS6ST1 HS6ST2 HS6ST3 NDST2 NDST1 NDST4 NDST3 EXT1 B4GALT7 HS3ST3A1 EXT2 CHST12 CHST11 CHST13 CHST14 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260810%WP5572%HOMO SAPIENS Nucleosome remodeling complex RBBP4 H4-16 H4C1 SMIM40 H4C6 XRCC6 XRCC5 CHEK2 IPO4 NASP-1 ASF1A SUPT16H MCM2 NAP1L1 SSRP1 PRKDC HAT1 CHAF1B PCNA ASF1B DAXX CHAF1A AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260810%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy CYBB PRKAA1 CACNA1S CAPN3 MCU TOMM20 SLC25A5 NFKBIA STIM1 CASQ1 SMAD4 TNNI1 TNF MMP9 FKBP1A TGFBR2 CCN2 FGB IL10 FGA TRPC1 PRKAA2 IL1B FGG SERPINE1 IL1A AGTR1 DMD PLAU ITPR1 GLI1 SPP1 VDAC1 SGCA DAG1 TGFBR1-1 CACNA2D1 PLA2G2A-1 CASP9 TRPC6 TRPC3 CACNB1 CACNB2 PRG3 NOS2 SSPN CACNG1 ATP2A1 HSPA9 CAMK2D MCUB SCX TRDN SARAF TGFB1 DTNA GP2 SNTB1 NFKB1 IL6 SMAD2;SMAD3 ELANE MPO PPIF ORAI1 MMP2 NOX4 SIGMAR1 ITPR2 RYR1 PLA2G4A ITPR3 CACNA1F MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260810%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 EGF STAT5A TIMP1 ESR1 FN1 PGR FOSL1 NRIP1 VIM CCND1 MYC AREG ERBB2 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260810%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex TBP TAF12 HDAC2 MBD2 HDAC1 TLK2 POLR1A POLR1B POLR1C POLR1D MTA1 KAT2B MAPK3 HAT1 CREBBP MBD3 H2BC15;H2BC3;H2BC11;H2BC12 SRCAP RBBP4 UBTF H4-16 H4C1 H4C6 H2AC14 H2BC21 H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ASF1A H2BC5 H2BC1 H2AC20 H2AB2;H2AB3;H2AB1 ASF1B PWWP2B CHD3 PWWP2A RRN3 GATAD2B TAF1D TAF1C MTA2 TAF1A CHD4 GATAD2A CDK2AP1 TAF1B EP400 EP300 KAT2A APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260810%WP1772%HOMO SAPIENS Apoptosis modulation and signaling BIRC3 HRK AIFM2 TNFRSF25 IRAK1 PIDD1 RIPK1 FADD TNFRSF1B MADD BOK BCL2L10 NFKBIA BCL2 TOLLIP FASLG CASP10 MYD88 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MAP3K5 MAPK3 APAF1 TRADD DAXX CASP8 PMAIP1 CASP3 BAG3 SMIM40 BIRC5 FOS CYCS-1 TRAF3 BID TRAF6 BAD TP53 FAS BIK BAX CAPNS1 HSPA1A;HSPA1B AIFM1 CASP6 CASP2 JUN PTPN13 TNFSF10 XIAP BMF MCL1 CASP9 IKBKB BNIP3 CASP7 CASP1 CRADD BAK1 CDKN2A TNFRSF1A CASP5;CASP4 PRKD1 MAPK8 NAIP BIRC7 NFKB1 MAP3K14 PEA15 SEPTIN4-1 ENDOG HTRA2 PTRH2 DIABLO-1 DFFB IL1R1 IL1R2 DFFA BCL2A1 BCL2L1 BBC3 BCL2L11 CFLAR BIRC2 BLK BCL2L2 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260810%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling MAPK14 ATF2 JUNB MAP2K3 MAPK12 MAPK13 IFITM3;IFITM2;IFITM1 MAPK10 DDIT3 MAPK11 MAP2K2;MAP2K1 BCL2 MAP3K4 BST2 MAPK1 MAP2K4 RAF1 EIF4E MAP3K11 MAP2K6 RPS6KA2 MAPK3 RPS6KA1 MAPK8 MAP2K7 MAP3K1 FOS MAP3K9 RPS6KA3 MAP3K10 MAPK9 JUN CAMKK2 PATHWAY%WIKIPATHWAYS_20260810%WP4874%HOMO SAPIENS CAMKK2 pathway CYB5R3 ACACA TSC1 SLCO3A1 MTOR FASN SMC1A STIM1 CDC25A MAPK1 RAF1 CRTC2 CCNE1 GATM FIS1 MAPK3 HMOX1 IFI44L CREB1 PFKFB2 GIT1 CAMK1 PFKFB3 GCK CAMK4 NEDD4L RASGRP1 ABCA1 KEAP1 HIF1A CD28 S100A8 NLRP1 FAM20C CCND1 CPOX MAP1LC3B2;MAP1LC3B-1 MAP1LC3A IL15 WDR35 MID1 HMBS SPINT1 SLC38A5 NOS1 WFS1 TRPV4 SPIRE1 MS4A3 OASL ERMAP PAK1 PCK2 GALNT9 MAMDC2 ATP10D TSPAN33 SLC25A21 AHSP EP300 TMEM176B IRGC HDAC4 KLF1 RHAG SQSTM1 ASNS SLC2A4 ATP1B2 NFE2L2 CXCL11 RPTOR TBXT AQP1 CHRM3 RPS6 TNF RPS6KB1 ICAM1 KDR RAC1 SIRT1 PLAC8 SELL DNM1L ARHGEF7 RELA EPOR VCAM1 CCL5 SREBF1 C1QTNF12 MAF PARP1 HFE TSPAN8 NFATC2 CTSE CALM1 CAMKK2 CCR9 SLC2A1 HK2 HK1 ULK1 CDH1 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260810%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence PTGS2-2 PTGIS ALOX15 ALOX12 LTC4S ALOX15B DPEP1 HPGD LTA4H CYP2C9;CYP2C19 GGT1 PTGDS PTGES FADS2 CYP2E1 ALOX5 CYP1A2 FADS1 GSTP1 CYP2D6;LOC107987479;LOC107987478-1 ELOVL2 GSTM4 GPR32 ELOVL5 EPHX2 TBXAS1 PTGS1 PLA2G4A CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FPR2 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260810%WP4758%HOMO SAPIENS Nephrotic syndrome CYP11B1;CYP11B2 YARS1 SCARB2 GPC5 SMARCAL1 ARHGAP24 PTPRO APOL3;APOL4;APOL1;APOL2 E2F3 SYNPO TTC21B WDR73 COQ6 TRPC6 COQ2 ITGA3 PDSS2 ACTN4 PAX2 CD2AP INF2 COL4A4 COL4A3 COL4A5 MYH9 LMX1B ITGB4 ZMPSTE24 CD151 ARHGDIA LMNA MYO1E NPHS1 NPHS2 WT1 LAMB2 PMM2 CTLA4 PODXL EMP2 CUBN ALG1 ANLN PLCE1 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260810%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells PSAT1 SLC2A1 SLC7A11 GLS SLC1A5 PHGDH PSPH KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260810%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway TNF PLCG1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SYK PTPN2 PRKCQ IFNG RAC1 LAT PTPN6 PRKCA CD34 GRB2 CSF2 LCP2 HRAS VAV1 ITPR1 TYROBP FYN HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling PTPN11 PTGS2-2 DOCK1 CRK PXN PTEN MAP2K2;MAP2K1 ITGB1 PIK3CA GRB2 MAPK1 MET MAP4K1 GAB1 RAF1 HRAS MAPK3 MAPK8 HGF FOS SOS1 ELK1 ITGA1 RAP1B PTK2 RAP1A SRC RAPGEF1 PAK1 STAT3 CRKL PTK2B RASA1 JUN SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260810%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260810%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition TNC SMAD2;SMAD3 AKT2 AKT3 SNAI2 FN1 CDH16 MAPK1 AKT1 RUNX2 VIM MAPK3 CDH2 SMAD4 CDH1 ID1 CDH6 SNAI1 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260810%WP2363%HOMO SAPIENS Gastric cancer network 2 DSCC1 BRIX1 ATAD2 CACYBP FAM91A1 RNF144B CD48 COL9A1 COL9A3 EGFR LMNB2 FANCI AHCTF1 RFC3 RFC4 MTDH S100A6 PLAC8 OTUD5 RAD17 LBR UBE2T TP53 TOP2A CHTF18 CTNNB1 CEBPZ SNURF MYC UBE2C VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260810%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling TAOK2 MAP2K3 PRKAA1 PIK3R2 PIK3R1 MTOR MAP2K2;MAP2K1 PIK3CA MKNK1 PBK MAPK1 AKT1 RAF1 EIF4E MAP2K6 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MAP3K5 MDM2-2 MAPK3 CLTC MAPKAP1 RICTOR ABL1 ROCK1 TEAD4 TRAF3IP2 RHOA PTK2 PLCB3 PSMD4 FOXO3 NR4A3 ANXA1 TUBA1C AP2A1 KL AP2S1 CALU ERG TFAM-1 PRDX2 TNXB ITGB5 HMGB1-1 FN1 BRD4 NOX4 MMP2 HDAC4 PTGS2-2 HDAC5 ATF2 TUBB4A;TUBB;TUBB8B;TUBB8 HDAC1 HDAC9 HDAC7 CDC42BPB ATP6V1E1 ICAM1 CDH5 KDR CCN2 RAC1 PRKCA S1PR1 CCL13;CCL2 SRC CTNND1 PLAU PTK2B SHB FYN PRKCI JUN PRKCE FRS2 PTPN11 MAPK14 SELE MMP14 PPP1CA CRK GSK3B PRKCZ PXN IQGAP1 PPP3CA BMX RCAN1 PRKG1 PRKD2 MAP2K4 PDPK1 PRKD1 MAPK8 SLC8A1 PPP2CB;PPP2CA MAP2K7 NFATC2 VPS39 NFKB1 CAMKK2 SHC2 ABCF2-H2BE1;ABCF2 STAT6 FOXO4 BMP2 STAT1 ACOT9 STAT3 CSRP1 RAB5A BSG NDRG1 MMP10 ACACA ARPC5L EZR NR4A1 ITGB1 ARF6 FLT1 HSPB1 GAB1 DECR1 SHC1-1 CREBBP SDF2L1 HYOU1 FOXO1-1 NR4A2 CREB1 CFL1 LIMK1 FXR2 CSRP2 DPM1 ACACB PTPRJ HBEGF NCK1 PLAUR ASCC3 SOD2 MYH9 VCL DKK1 JAG1 HERPUD1 VEGFA GPX1 QKI CDC42 ADAM9 PAK1 PLA2G4A VAV2 DNAJA1-1 EIF4G2 FADD ADAM10 NFKBIA CXCL8 ADRB2 MLST8 TPCN2 PRKRA TRPC1 PFN1 CCN1 INPP4B RHOC TMSB10 RELA MAPK9 FSCN1 MAPK12 LMAN1 PTPN6 PLA2G5 TKT ITCH PSMD11 MEF2C NUMB GATA2 DUSP5 ADAMTS1 RAPGEF1 FLNB LDHA HBD;HBB ACKR3-2 SRPK1 TNFRSF25 GLUD1;GLUD2 BCAR1 YWHAE SRP54 ELOC-1 GAPDH-1 GPC1 WASF1-1 ITGB3 ITGAV PGF ALDOA PPM1G PRKAA2 RBM39 ELK1 RAP1B RAP1A HSPA1A;HSPA1B P4HB IDH2 PLCG1 CCT7 RPL10A GRB10 HSP90AA1 SET-1 RPL7 HGS NOS3 PRDX6 STAM RPL18A ELOA EPN1 RPLP2 RPS11 CBL CSK GJA1 EPS15 OCLN-1 AMOT RPL13A-1 RPL27 RPL26 EPHA2 AFDN SPIRE1 CTNNB1 NAPA PRKCB ATF4 RPL5-1 PGD EGR3 NFATC1 LUC7L TXNIP IER5 SND1 EWSR1 BCL2 BIN1 GRB2 GIGYF2 ARRB2 PRRC2C TRIP4 SYNJ1 LARP7 GIPC1 RACK1 KCNC3 EEA1 CTNNA1 CGNL1 SSR4 HRAS PAK2 SSR3 ENG KANK1 PGK1 SLC7A1 APOLD1 FGD5 TPP1 PLOD3 SEMA6D ARMCX1 RAB37 DSC1 LRRC59 BIRC5 STIP1 TXNDC5 SARS1 TFCP2 FGB RCAN2 FGA CYCS-1 BMP10 NRARP CAPZB ACP1 ADAMTS9 FGG PBXIP1 PTPRZ1 F3 DNAJB4 FAS SLC25A25 PTPN14 PTPN9 UBAP2L CHAC1 TMEM170A KATNAL2 FUT1 MAPKAPK5 ZNF555;ZNF57;ZNF556 ATP6V0D1 EPB41 PABPC1;PABPC3 DHX36 MICAL2 DHX29 CCDC124 EPHB2 CLIC1 AKT1S1 FJX1 NEXN CRIP2 COPG1 TMOD3 HTRA1 SCUBE2 ZC3H15 CACNA2D1 GRSF1 C15orf39 RND1 LRRFIP2 ARHGEF15 SHROOM2 RCN1 MMRN2 USP10 HLX DOK1 FAM120A PDE4DIP FMNL3 TAL1 ETS1 SDCBP NOTCH4 SMARCA2 RAB4A RAB11A CNP ARNT CCRL2 DLL4 ROCK2 FHL2 LDB2 ACTG1 TMOD1 SLC25A11 RHOJ MYL2 SIAH2 MYO1C IGFBP3 IGFBP7 NAP1L1 CCND1 PTPN1 TPM3 CAV1 FAF1 BCL2L1 EIF4G1 NCF1 CALR-1 NCF2 DNAJB9 INPP5K EIF2A NRP2 EIF2AK3 CYBB PDIA6 ERN1 ATF6 MYO6 EIF3H RPS6KA5 EIF3F EPRS1 EIF3D FARSB RPS6 PRKCD RPS6KB1 ALB TXN P4HA2 MYH11 ARF4-1 TRPC3 FBXW11 OCRL CAPN2 TBCA MOV10 NCL-1 EGR1 SRF FHOD1 MAPKAPK2 SH3BGRL3 FLII PNP-1 PTMA SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260810%WP5598%HOMO SAPIENS Sodium channel in epilepsy GSK3B BACE1 AKT1 SCN5A WEE1 PTPRN RACK1 NEDD4 SCNM1;TNFAIP8L2-SCNM1 SCN11A JAK2 PDCD10 CAMK2A SCN7A SCN3A PRRT2 SCN1B NFASC SCN4A SCN2B RNF121 TNF SCN9A SCN10A SCN8A SCN4B CALM1 SCN1A FGF14 SCN3B MAPK8IP2 FGF13 FGF12 NEDD4L SCN2A PSEN1 FYN OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260810%WP5574%HOMO SAPIENS Oligodendrocyte development NKX6-1 ZBTB33 CSPG4 SMAD1 OLIG1 EGR2 OLIG2 FGF2 ID4 GLI2 RELN SHH SOX8 SOX6 WNT10A NKX2-6 ID2-1 MYT1 MAG ZEB2 PDGFRA SOX2 MYRF CHD7 SOX11 PTN ZNF24 DUSP15 ZNF488 LGI1 NFATC2 OPALIN BMP4 TMEM98 CHD8 CNTN1 SOX9 ASCL1 SOX5 PRKCA NFIA HES5 PTPRZ1 TCF7L2 SOX10 MBP NKX2-2 BMP1 VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260810%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders PNPO ALDH7A1 ALPL PIGV PDXK ALPG;ALPP;ALPI-1 PLPBP MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260810%WP5236%HOMO SAPIENS Markers of kidney cell lineage PBX1 TLX1 FAT4 OSR1 SMAD1 RSPO3 RSPO1 SMAD5 LHX1 SIX1 EGLN3 HNF1A ALDH1A2 SALL1 PDGFRB SIX2 KDR DES SFRP1 NTN1 REN EGLN1 FGF7 HNF4A NOTCH2 TCF21 NOTCH1 EPO EMX2 FOXD1 EYA1 HNF1B NT5E WNT4 FGF8 GDNF PAX2 WNT5A TNC AXIN2 JAG1 BMP4 AP2B1 DCN CITED1 NPHS1 DACT1 KIT NPHS2 KCTD1 PECAM1 WT1 TSHZ3 TBX18 VSX2 EGLN2 BMP7 ACTA2 FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260810%WP143%HOMO SAPIENS Fatty acid beta oxidation CHKB LPL ACAT1 CPT1B ACSS2 LIPC GK HADHB-1 ECHS1 TPI1 ACSL6 ACSL5 ACSL4 ACADVL DLD PNPLA2 ACADS HADH ACADM DECR1 LIPE ACSL1 HADHA GK2 LIPF ACSL3 GPD2 ACADL ECI1 CRAT SLC25A20 CPT2 GCDH CPT1A DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260810%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection ELOC-1 RBX1 UBB;UBC ELOB RUNX1 CUL5 CBFB NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260810%WP4255%HOMO SAPIENS Non small cell lung cancer PRKCG PRKCB RB1 PIK3CD STAT5A STAT5B RET E2F3 PIK3CB MAP2K2;MAP2K1 BRAF PIK3CA GRB2 KRAS CDKN1A MET MAPK1 AKT1 RAF1 JAK3 HRAS MAPK3 E2F1 CASP8 DDB2 RXRB GADD45B CRABP2 GADD45A CASP3 RXRA SOS1 CRABP1 GADD45G SOS2 CDK6 AKT2 CYCS-1 AKT3 NRAS PRKCA CDK4 KIF5B STK4 BID BAD TP53 BAX FOXO3 PLCG2 PLCG1 ALK CASP9 POLK RARB TGFA E2F2 BAK1 PDPK1 CDKN2A EGFR CCND1 EML4 HGF ERBB2 FHIT EGF RASSF1 RASSF5 KIF5C KIF5A RXRG STAT3 ARAF 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5406%HOMO SAPIENS 13q12 12 copy number variation TRAF5 SGCD TRAF1 SGCA SGCB DAG1 SGCG RTN4R MAG SSPN SNTA1 RTN4 MAPK8 MIPEP DTNA TRAF2 SACS LINGO1 SNTB1 RAC1 TRAF3 RHOA C1QTNF9B;C1QTNF9 ATXN1 TNFRSF19 SPATA13 ADIPOQ CDC42 DMD FLNC MAPK9 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260810%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PTGS2-2 PLA2G4F PLA2G1B PLA2G12A PLA2G12B PLA2G4D PLA2G4E PLA2G7 PLA2G5 SLCO2A1 PLA2G6 PLA2G3 TP53 PLA2G10;LOC100652777 CDKN1A PLA2G2D PLA2G4A HRAS ALOX5 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260810%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons DRD3 ADCY2 DRD4 PPP1CA GNG2 DDC CHRNA4 GNAI1 CDK5 SLC18A2 KCNK9 CHRNA5 GNB1 CHRNA6 DRD2 CHRNA3 PRKACA-1 TH KCNK3 CHRNB2 PPP1R1B HUNGER AND SATIETY%WIKIPATHWAYS_20260810%WP5445%HOMO SAPIENS Hunger and satiety PYY LEP GCG POMC MC4R GHRL NPY AGRP CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260810%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction CCL14 ACKR3-2 TNFRSF13B TNFRSF25 CD27 CCL8 CCR8 CXCL17 CXCL14 CCL1 IL36A IL36B IL36RN XCL1;XCL2 IL36G PPBP IL1F10 IL9 IL20 IL26 IL24 CSF3R TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A IL27 MSTN CCL25 IL13 CCL24 IL31 CCL22 IL37 GDF11 CCL27 TNFRSF11B CCL26 NGF ACVR2B TNFSF9 IL23R IL17RB IL23A IL17RC IL17A IL17RA LTA IL7R EDAR CCL19 BMP15-1 IL12RB1 GDF9 IL12RB2 IL3RA CCL28 IL18R1 CXCL12 AMHR2 IL18 IL34 IFNG IL15 IL18RAP IL21R CXCR2 IL1R2 BMP6 CSF2 BMP5 BMP3 LEP NGFR CXCL2;CXCL3;CXCL1-1 GDF15 IL2 CD40LG TGFB2 IL5RA IL33 IL2RG TNFRSF1B IL5 IL2RA IL2RB FASLG ACVR1 LIFR LIF TNF TGFBR2 IL10 CX3CL1 BMP10 CCL23;CCL15 CCR5 IL1A FAS CCL13;CCL2 GHR IFNGR1 IFNGR2 EPOR IL1RAP TGFBR1-1 GDF7 LTB IL11RA IL6ST TNFRSF1A CCR10 CSF2RB CCR1 XCR1 TGFB1 IL7 CCL11 IL20RA CCR9 CXCR4 IL20RB CCR7 CCR6 CCR4 TNFRSF19 IL31RA IL4R BMPR2 CSF3 BMP7 BMPR1B TNFSF14 IL19 GDF2 GDF1 GDF6 IL4 CXCL5;CXCL6 RELT GDF10 CD70 BMP8B CLCF1 TNFRSF8 IL13RA2 TNFRSF17 INHBC INHBE ACVR1C BMPR1A EDA IL10RB EDA2R IL10RA CNTFR MPL IL27RA IL9R CSF2RA IFNLR1 IL22RA1 GDF3 PF4;PF4V1-1 CX3CR1 TNFSF13B TNFSF10 TSLP CSF1R CNTF IL25 AMH ACKR4 CCL20 CSF1 EPO IL17F IL17D IL17C IL17B CCR3 CCR2 ACVRL1 TPO CXCR1 TNFSF11 PRL IL6R TNFRSF11A ACVR2A IL11 TGFB3 INHBA GDF5 PRLR BMP4 IL3 IL6 IL1RL1 NODAL IL1R1 NFIC IL1RL2 IFNAR2 ACVR1B CCL3L1;CCL3L3;CCL3;CCL18 IFNAR1 TNFRSF21 LEPR CXCL10 CXCL11 INHA CXCL9 CD40 CXCL8 TNFRSF9 LTBR INHBB IFNK IL21 IL22 CXCL13 CXCR5 CCL21 CCL4L2;CCL4L1;CCL4 TNFRSF4 CCL5 TNFRSF18 IFNB1-4 TNFSF15 TNFRSF12A IL1RN TNFRSF13C TNFRSF14 TNFSF4 IL13RA1 ANP32B IFNL2;IFNL3;IFNL1 CXCR6 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260810%WP1422%HOMO SAPIENS Sphingolipid pathway PPP1CA SPTLC3 CERT1 ACER1 SERINC1 CERK SGMS1 GBA SGMS2 GBA2 UGT8 UGCG SGPL1 KDSR CERS3 CERS4 CERS6 PPP2CB;PPP2CA SGPP2 CERS2 B4GALT6 PLPP1 ASAH1 ASAH2 CERS5 SPTLC1 SPHK2 SPHK1 GAL3ST1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260810%WP4249%HOMO SAPIENS Hedgehog signaling GLI1 SMURF1 CSNK1D DHH CCND2 CSNK1G3 FBXL17 SPOPL GLI2 GPR161 CSNK1G2 SHH BCL2 ARRB1 ARRB2 IHH PRKACA-1 GLI3 CCND1 TPTEP2-CSNK1E;CSNK1E PRKACB-1 CSNK1G1 KIF3A BOC CDON CSNK1A1 HHIP PTCH2 KIF7 SMURF2 SPOP LRP2 GRK2 EVC PTCH1 GRK3 EVC2 GAS1 SMO CUL3 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260810%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia WIF1 ZBTB16 APC GSK3B SALL4 AKT1 WNT1 FZD6 PPARD CCND1 RUNX1T1 CSNK1A1 DKK1 AXIN2 PML RARA LEF1 LRP5 LRP6 PYGO1 BCL9 CTNNB1 MYC FLT3 JUP VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260810%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption RAB11A AQP2 RAB11B AQP4 PRKACA-1 ARHGDIG PRKACB-1 ADCY3 ARHGDIA DYNC2H1 CREB3 CREB1 AVP DYNC1H1 DYNC1I2 ADCY6 VAMP2 CREB5 AQP3 RAB5B DCTN5 ARHGDIB DCTN2 GNAS-1 RAB5C DYNC2LI1 NSF DYNC1LI1 STX4 DYNC1LI2 AVPR2 ADCY9 CREB3L3 DYNC1I1 CREB3L4 DCTN6 DCTN1 CREB3L1 CREB3L2 DCTN4 RAB5A BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260810%WP3927%HOMO SAPIENS BMP signaling in eyelid development MAP3K1 FOXC2 FOXC1 SMAD1 NOTCH1 INHBB BMP4 SMAD5 FGFR2 FGF10 TGFA SHH SFRP1 EGFR MAPK3 SMAD4 PITX2 JUN DKK2 MAPK9 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260810%WP550%HOMO SAPIENS Biogenic amine synthesis GAD1 TPH1 GAD2 DDC CHAT PNMT MAOA ASMT DBH COMT HDC AANAT TH PAH ACHE NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260810%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling SOCS3 PDHA1 ARC GLUL GRIA1 GRIA2 NSMF GRIN2A SLC38A3 DLD SLC1A1 TRPM4 MAPK1 AKT1 SLC1A2 LRRC8C SLC1A6 LRRC8D LRRC8B GRIA3 LRRC8E GRIA4 MAPK3 IRS1 GRIN3B IL13 IL10RB SMAD4 GRIN3A IL10RA GRIK5 GRIK3 NGF GRIK4 ADCY3 GRIK1 ADCY1 GRIK2 CREB1 ADCY8 GRM2 GRM4 GRM7 GRM8 LRRC8A CFL1 PLCB3 PLCB4 GRIN1 CAMK4 LTA PLCB1 PLCB2 CNTF TRAF5 GRIN2C GRIN2D SRR IL6R TGFB3 SMAD7 SLC6A9 CAMK2B GRM1 CAMK2G IFNG IL6 PPP1CB SLC1A4 PPP1CC IL1R1 IL1R2 IL12B SLC38A5 NOS1 IL12A SHMT2 SHMT1 INSR PRKCG PRKCB SLC17A6 GRM5 SLC17A7 TGFB2 TNFRSF1B NFKB2 BCL2 GLS PRKACA-1 LIF CAMK2A TGFBR3 GRIN2B TNF TGFBR2 FOS IL10 PRKCA SLC7A10 IL1B IL1A PHGDH PSPH IFNGR1 IFNGR2 PSAT1 PPP1CA DISC1 TGFBR1-1 FGF2 SLC38A1 IL6ST TNFRSF1A CAMK2D SLC38A2 TGFB1 IGF1 NFKB1 SMAD2;SMAD3 CALM1 CAMKK1 IL13RA1 CAMKK2 SLC1A3 GOT1-1 GLS2 SLC2A1 STAT6 JAK1 IL4R STAT1 GFAP STAT3 DAO BDNF IL4 DLAT MIRNA BIOGENESIS%WIKIPATHWAYS_20260810%WP2338%HOMO SAPIENS miRNA biogenesis DGCR8 RAN TARBP2 DICER1 XPO5 DROSHA METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260810%WP2249%HOMO SAPIENS Metastatic brain tumor TP53 CDC42 E2F3 CDK6 PIK3R1 MYC DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260810%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family TSLP BCL11B ZBTB16 IL25 IL33 IL5 ID2-1 RORA IL9 IL18 HNF1A GFI1 IL13 AREG EOMES TNF NFIL3 IFNG IL7 IL15 IL6 TOX TBX21 IL1B GATA3 RORC AHR IL12B IL12A IL23A IL17A IL22 IL4 MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260810%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome HDAC1 SIN3A FKBP5 MTOR CNP GRIA1 YBX1 GAMT CTCF GPRIN1 AKT1 FGF5 MYT1 SGK1-1 MAG GRIA3 GRIA4 NF1 HNRNPH1 PSIP1 FGF3 CAMK2A RBFOX1 GRID1 TET3 E2F1 RPS6 ARHGEF26 BCL6 MECP2 DLX6 IGF2 NREP MPP1 PRPF38A POU4F1 CREB1 HNRNPF GABRR2 GRIN1 REST SST TAP1 OPRK1 DHX9 APOC2 TET1 FGF2 FGF4 PTEN SP1 SP3 FUT8 EZH2 TARDBP CEBPD MEF2C NCOR1 TAF1 TET2 POU3F2 CDON GAD1 IGF1 FOXG1 UBE3A SMC3 DLX5 FUS MBP IGF1R BDNF CSRP1 NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260810%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism NEU2 FUCA1 B4GALT3 B3GNT5 NAGA FUT2 FUT6;FUT5;FUT3 FUT1 ST3GAL4 B4GALT4 B4GALT1 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260810%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells CYP2B6 CYP2A13;CYP2A6;CYP2A7-1 FMO3 AOX1 STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260810%WP4463%HOMO SAPIENS Steroidogenic pathway CYP19A1 CYP17A1 HSD17B1 HSD3B1;HSD3B2 STAR CYP11A1 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260810%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis SLC2A1 PCSK1 PCSK2 GCG GLP1R INS;INS-IGF2 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260810%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis FTL-1 TNF RIPK3 RIPK1 TNFRSF1A PLA2G4A FADD MAPK8 TICAM1 PARP1 TRADD CASP8 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260810%WP5366%HOMO SAPIENS NF1 copy number variation syndrome CRY1 TUBB4A;TUBB;TUBB8B;TUBB8 RAB11A RBBP7 EZH1 ARF6 MAVS BCL2 ROCK2 MAPK1 OMG CCNE2 MYT1 RAF1 CCNE1 NF1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MAPK3 SUPT5H EIF3A DDX58 PCNA NGF MAP3K2 H4-16 H4C1 H4C6 SOS1 HOXA9 RFC5 POLRMT RFC3 EXOC4 RFC4 EXOC3 RAD51 EXOC6 RFC2 EVL SUZ12 EXOC5 CFL1 EED ATAD5-1 EXOC1 RHOA RNF135 ADAP2 LIMK1 INPP5A RAD9A E2F6 ATR RAB11FIP4 TEFM EXOC8 UTP6 COPRS EVI2A CRLF3 EVI2B WDR48 EXOC2 DNMT1 METAP2 CCNA2-1 EXOC7 JARID2 IFNB1-4 MCL1 RTN4R PRMT5 EGFR USP1 MAP3K1 EGF HOXA1 SDC2 SYN1 NGFR PER1 INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260810%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition RPS6KB1 INSR SLC2A4 AKT2 IRS1 MTOR TBC1D4 RPS6 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260810%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC7A11 ATF4 SLC1A5 SLC7A5 NFE2L2 KEAP1 SLC3A2 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260810%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure PARP2 BAX CASP3 MAPK10 PRDX2 HSD3B1;HSD3B2 STAR CYP11A1 SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260810%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling HTR2B NRAS SRF MAP2K2;MAP2K1 ELK1 ELK4 HTR2A KRAS MAPKAPK2 MAPK1 RAF1 RASGRF1 GATA4 GNAQ HRAS MAPK3 ITPR1 RASGRP1 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260810%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism HMGCLL1 MCCC2 BCKDHA ACAT1 PCCA MCCC1 PCCB ECHS1 HIBADH AUH ALDH6A1 HIBCH ACADSB HSD17B10 DLD BCAT2 BCAT1 BCKDHB IVD ACAD8 ACSF3 DBT MMUT MLYCD 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome PCYT1A STAT5A PIK3R3 STAT5B FBXW7 ADAM10 GRIA1 NF2 NCBP1 PAK2 SIRT1 RNF168-1 NCBP2-1 CEP19 MCRS1 H2BC21 MYCBP2 JUN HIF1A NRROS PIGZ SLC51A SENP5 SLC51B UBXN7 MAD2L1BP-1 RNF8 SMCO1 FBXO45 BRINP1 PIGX-1 PXN TM4SF19 CEP350 WDR53 ZNF76 CASP7 PIGM MELTF UBE2N HFE TGFB1 DYNC2H1 DYNC2I2 DYNC2I1 DYNLT1 DYNLT2B TF TFRC DYNC2LI1 SLC40A1 HAMP DLG1 DYNLRB2 DYNLRB1 RABL2A;RABL2B MYC FNDC8 CEP43 THERMOGENESIS%WIKIPATHWAYS_20260810%WP4321%HOMO SAPIENS Thermogenesis BMP8B MAP2K3 PRKAA1 PPARGC1A TSC2 TSC1 MTOR FGFR1 ACSL6 ACSL5 ACSL4 KRAS PNPLA2 RPS6KA6 MAP3K5 ACTG1 ADCY4 ADCY3 ADCY2 ADCY1 CREB1 CNR1 ADCY8 ADCY7 ADCY6 ADCY5 PRKAA2 ADCY10 ADCY9 SMARCA4 KLB BMP8A;BMP8B ZNF516 KDM3B SLC25A29 LIPE PLIN1 PRKAG1 PRKAG2 PRKAG3 MGLL PRKAB2 PRKAB1 ACTB-1 CPT2 CREB3L3 CREB3L4 CPT1C ARID1A CREB3L1 CREB3L2 ATF2 CPT1B GCG PRDM16 UCP1 GRB2 RPTOR RHEB NPR1 PRKACA-1 RPS6KA2 HRAS RPS6KA1 ACSL1 RPS6 PRKACB-1 MLST8 RPS6KB1 RPS6KB2 PRKG2 CREB3 SOS1 SOS2 CREB5 SIRT6 NRAS ACTL6A AKT1S1 FRS2 MAPK14 MAPK12 MAPK13 MAPK11 PRKG1 FGF21 KDM3A KDM1A SMARCB1 SMARCD1 SMARCD2 ACSL3 SMARCD3 DPF1 DPF3 PPARG SMARCE1 SMARCC1 SMARCC2 GNAS-1 ARID1B SLC25A20 ACTL6B SMARCA2 RPS6KA3 ADRB3 CPT1A HEME BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP561%HOMO SAPIENS Heme biosynthesis HMBS CPOX PPOX ALAS1 ALAD ALAS2 FECH UROD UROS ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260810%WP474%HOMO SAPIENS Endochondral ossification TIMP3 HDAC4 MMP13 STAT5B COL2A1 TGFB2 PTHLH CAB39 FGFR1 SCIN SOX6 AKT1 IHH BMPR1A PRKACA-1 ENPP1 THRA GLI3 PTH IGF2 PTH1R MMP9 KIF3A PLAT FGF18 SERPINH1 GHR PLAU IFT88 CDKN1C HMGCS1-1 SPP1 ALPL FGF2 CTSV;CTSL MEF2C RUNX3 SLC38A2 MGP TGFB1 IGF1 VEGFA CALM1 SOX9 SOX5 PTCH1 BMP6 ADAMTS4 ADAMTS5 ADAMTS1 COL10A1 STAT1 NKX3-2 BMP7 IGF1R DDR2 RUNX2 ACAN CHST11 FRZB FGFR3 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260810%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260810%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement PLCG1 VCL ITGAV CREB1 PRKCQ MYLK ACTN1 PXN PTK2 TJP1 MFAP5 LPP MAPK1 MYL2 MAPK3 ITPR1 ITGB3 JUN FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260810%WP206%HOMO SAPIENS Fatty acid omega oxidation CYP2A13;CYP2A6;CYP2A7-1 ALDH2 ADH1C;ADH1B;ADH1A CYP2D6;LOC107987479;LOC107987478-1 ADH4 CYP1A1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 CYP1A2 SPINAL CORD INJURY%WIKIPATHWAYS_20260810%WP2431%HOMO SAPIENS Spinal cord injury RB1 CDKN1B MMP12 COL2A1 NR4A1 ROCK2 MAPK1 OMG MAG VIM MAPK3 E2F1 TACR1 GADD45A CDK4 CDK2 CDK1 RHOA PTPRA GRIN1 FOXO3 SELP BTG2 CCNG1 TNFSF13B LGALS3 SLIT2 ANXA1 CCR2 GDNF RTN4R SEMA6A PDYN BCAN NOS2 KLK8 ROS1 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 ARG1 NCAN EGFR VCAN CCND1 MIF GJA1 IFNG IL6 EFNB2 IL1R1 NOS1 LEP NGFR NOX4 CDC42 COL4A1 CXCL2;CXCL3;CXCL1-1 IL2 MYC EPHA4 PTGS2-2 CSPG4 XYLT1 C5 CD47 C1QB AIF1 CXCL10 AQP1 CXCL8 TNF MMP9 ICAM1 FKBP1A CASP3 FOS RAC1 GAP43 PRKCA IL1B ZFP36 RGMA IL1A PTPRZ1 TP53 CCL13;CCL2 RHOC RHOB NTN1 TLR4 LTB4R SLIT1 SLIT3 PLA2G2A-1 PLA2G5 PPP3CA E2F5 APEX1 PLA2G6 LTB AQP4 RTN4 TGFB1 SOX9 EGR1 MBP PLXNA2 GFAP ACAN CHST11 BDNF IL4 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260810%WP4298%HOMO SAPIENS Acute viral myocarditis ITGB2 ITGAL EIF4G2 AIF1 CXADR PIK3R1 NFKB2 BCL2 MAPK1 CD55 AKT1 MAPK3 ABL1 CASP8 TNF MMP9 CASP3 CREB1 LAMA2 SOS1 IL10 CYCS-1 BID CCR5 BAX SRC TLR5 RAC3 TLR4 MYH6 DMD TLR3 CASP6 PABPC1;PABPC3 CASP2 FYN CD4 SGCD ILK SGCA NOD2 SGCB GSK3B DAG1 SGCG CASP9 PYCARD CASP7 CCR3 CASP1 EDN1 KRT8 CAAP1 CCND1 CHRAC1 PARP1 BNIP2 TGFB1 CAV1 IFNG HLA-DMA IL6 ENDOG CXCR4 CD80 DFFB DFFA SOCS1 IL12B NOS1 JAK1 IL12A ACTB-1 BCL2L1 EIF4G1 STAT1 STAT3 ABL2 IL2 TICAM1 CD40LG PTCRA RASA1 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260810%WP3601%HOMO SAPIENS Lipid particles composition APOA2 LPL LCAT APOA1 APOC2 APOC3 APOE APOB LDLR CETP FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260810%WP5061%HOMO SAPIENS Fatty acid transporters FABP4 ACSBG2 SLC27A4 FABP7 ACSL3 FABP2 FABP6 ACSL6 ACSL5 ACSL4 CD36 ACSBG1 ACSL1 FABP9 FABP1 FABP3 FABP5 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260810%WP2005%HOMO SAPIENS miR targeted genes in muscle cell MTPN RB1 DNAJB1 CDKN1B POLR2C PPP1R7 GFPT1 POLD2 SH3BP4 E2F3 PDLIM7 MPZL1 SLC12A2 PKM GALNT7 GALNT1 TXNRD1 AP3D1 ARCN1 GRIA2 SPCS3 KRAS ATP6V0E2;ATP6V0E1 FMNL2 AXL NEDD4 EIF4E LAMTOR5 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CUL4B BET1 IRS1 E2F1 ATRX SLC7A11 LAMC2 CDK6 PAFAH1B2 HES1 PKN2 IFRD1 LPL NOTCH2 TP53INP1 CXCL12 BACE1 SLC25A13 GJA1 ERG PPIF SLC38A5 LAMC1 THBS1 COL3A1 COL1A2 CTNNB1 RAD23B HDAC4 ITGA2 EHMT2 TM6SF1 TYMS LRP1 BCL2 CDKN1A PANX1 MET YWHAQ RHEB G6PD FADS2 ITGB4 TGFBR2 PTPA CYP1B1 PRKCI PDE3A CSNK1D MAPK14 COL1A1 CACNA2D1 FGF2 SEC23A PPP3CA DSG2 EZH2 ZEB1 SEC24A MAPK7 CYP51A1 BACH1 MYLIP RAVER2 CDK5RAP1 ANKFY1 VPS39 CDK5RAP3 TMEM41B-1 MBNL1 SCAMP1 WDR82 FAR1 HACD3 RDH10 GRPEL2 SDCBP PODXL GSTM4 CLDN1 SFXN1 STRN ASH2L CSRP1 NELFCD SLC7A6 SRSF10 TTC9C PISD HIPK3 WDR11 SNX15 NUCB1 GPAM TUSC2 LTN1 LCLAT1 SHOC2 IPO4 ABHD10 CDIPT KPNA3 NF2 STX7 RAB30 DMTF1 SYPL1 CORO1C SLC9A3R2 HSD17B12 RAB6A HMOX1 CD164 NCOA3 CNOT9 SLC25A1 CALCOCO2 PGM1 ACP2 SNAP29 TPM4 PTBP2 SNAP23 PTPRF CA12 LUZP1 CLOCK TPM2 SYNE2 NUFIP2 TPM1 SYNE1 TMEM43 IGF2BP1 LRRC8A ZNF622 SLC25A24 SLC12A4 MYO10 SLC25A32 MTRR CHORDC1 SEC62 CARHSP1 METTL7A-1 MAGT1 EHMT1 PHLDB2 ATP6V0A1 SNX6 RAB27B CCNG1 C1QBP NCEH1 GFM1 PTPRJ COIL NOTCH1 TMED3 CSF1 MCL1 DHX15 ANAPC1 GNL3L-1 CTSC MRPS24 RHOG AP3B1 GAK CDCP1 NT5E FRG1 ESR1 ELMOD2 BRPF3-1 SSNA1 CEBPB AMIGO2 CAPG NAPG PGRMC1 ATAD3A;ATAD3B EGFR SPRYD4 UHRF1 CCND1 TPPP3 ERBB3 USP1 ERBB2 WNT5A CPOX TMEM87A ARID4B TPM3 HYAL3 TXN2 VSNL1 ARHGDIA FSTL1 ATG9A CAMTA1 UBE4A CDKAL1 GPD2 MYO1E WDFY1 MATR3 KIT GEMIN7 PPIB NFIA SLC1A4 IGF2R DNMT3A DOCK5 DOCK7 TNFAIP2 CHD1 MTHFD2 TMEM109 SPARC SCYL1 HSDL1 ACVR1B ARID1A RCN2 RFT1 RBMS1 NXN CAND1 SLC4A7 NAA15 TDG PLK1 ABCG2 TMED7 PDCD4 LAMTOR3 CCN1 POLE4 POLA2 GNA13 P4HA2 PSAT1 CPNE8 VEZT ACAA2 SRPRB-1 MAPK12 ARF4-1 PWP1 ANPEP CIAO2A POGLUT3 SLC38A1 RARS1 FNDC3B FNDC3A PDLIM5 DHX40 RAB34 RAI14 SRSF9 TMED10 CBFB ADIPOR2 RTN4 UBE2J1 MRPL20 COMMD9 SLC38A2 LMNB2 ATP6V1C1 KCNQ1 SLC4A10 TBCA MOV10 AGO3;AGO1 NCL-1 CHMP2A ANP32B PICALM NRP1 SRF TRAM1 ATP2A2 ADAR MRC2 UAP1 SPTLC1 SH3BGRL3 TMED2-1 CSDE1 GNPNAT1 PXDN PTMA CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260810%WP5601%HOMO SAPIENS Caffeine in blood vessels PDE3A PPP1R12A PPP1R12C RYR2 RYR3 NOS3 ADORA3 ADRA1D ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 MYLK ADCY7 ADCY6 ADORA2A PDE3B CALM1 PDE4B ADORA2B ADCY5 PDE4A ADRA1B PPP1CB ADRA1A GUCY1A2 GUCY1A1 CALM3;CALM1 CALM2 ADCY9 PDE4D-1 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260810%WP3935%HOMO SAPIENS Leptin insulin signaling overlap SOCS3 DGKZ PIK3R3 IRS2 LEPR INS;INS-IGF2 SOCS1 SOCS2 AKT1 LEP PDPK1 INSR STAT3 JAK2 IRS4 IRS1 PIK3CG INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260810%WP4558%HOMO SAPIENS Interferon mediated signaling IFNAR1 IFNB1-4 IFNG IFNE IFNK IRF9 PIK3R1 PRKCA IFNL2;IFNL3;IFNL1 IFNLR1 PIK3CA STAT2 JAK1 IFNAR2 STAT1 JAK2 IL10RB IFNGR1 IFNGR2 TYK2 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260810%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway MAP2K3 PRKAA1 PIK3CD PIK3R3 TSC2 SLCO1C1 TSC1 SLC16A2 PIK3R2 PIK3CB PIK3R1 MTOR THRB MAP2K2;MAP2K1 PIK3CA FASN EIF4EBP1 MAPK1 AKT1 FBP1 RAF1 EIF4E RPS6KA6 MAP3K11 MAP2K6 IRS4 MAP3K6 MAP3K5 THRA MAPK3 SHC1-1 IRS1 MAPKAP1 RICTOR FOXO1-1 MAP3K13 IRS2 FLOT1 AKT2 FLOT2 CAP1 MAP4K2 PRKAA2 MINK1 MAP3K9 RHOQ MAP4K5 MAP4K3 MAP4K4 FOXO3 EXOC7 LPL INS;INS-IGF2 CBLC MAP3K4 CYP7A1 ABCG8 ABCG5 PTPN1 PCK1 PRKAG1 PRKAG2 CBL PRKAG3 TRIP10 PRKAB2 PRKAB1 MAP3K8 INSR SLC2A4 RPTOR RPS6KA4 RHEB RPS6KA5 RPS6KA2 HRAS RPS6KA1 PIK3CG MLST8 RPS6KB1 MAP3K2 RPS6KB2 MAP3K3 RXRA SOS1 SOS2 CYP2B6 MAPK6 MAPK4 ANGPTL8 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MAP3K10 MAP3K12 MAPK9 GSK3A MAPK14 SESN3 SREBF1 CRK MAPK12 MAPK13 GSK3B SREBF2 MAPK10 MAPK11 PIK3C2G PIK3C2A MAP3K7 MAP4K1 MAP2K4 PDPK1 PIK3C3 MAPK8 MAPK7 MAP2K7 MAP2K5 CBLB PIK3R4 MAP3K1 SCD NR1H3 MAP3K14 SHC2 SHC3 SLC2A1 GYS1 RAPGEF1 RPS6KA3 G6PC1 CILIARY LANDSCAPE%WIKIPATHWAYS_20260810%WP4352%HOMO SAPIENS Ciliary landscape COPS4 COPS3 COPS8 RB1 COPS5 COPS2 RAB8A WDR26 RMND5A RANBP9 MKLN1 GID4 RAB2A MCM7 MCM10 YAP1-1 NUDC SNRPB2 MCM3 MCM5 MCM6 RNGTT PSMD8 PSMD7 MCM8 MCM9 MFAP1 MSH2 GLA GDI1 ZYG11B RALB RAB14 WEE1 COPS6 PSMC6 CDR2 PSMC4 NDUFA9 PSMD12 BBIP1 CTNNB1 PSMD13 RHBDD2 HDAC2 ANKS6 INTU HDAC1 SPATA7 NEK8 NEFM EFHC2 IQCB1 STOM RAC1 NEFL CCDC40 EXOC8 EIF5B EXOC2 LCA5 CTBP2 IQGAP1 CEP290 DVL3 ACSL3 NFKB1 PAFAH1B1 AFG3L2 CALM1 LCN2 HTRA2 UQCC1 IQGAP3 DDX5 TFAP2A TFAP2C TFAP2E;TFAP2B XPNPEP3 ECHS1 MKS1 VIM CREBBP CNOT9 SNAP29 EXOC4 EXOC3 EXOC6 EXOC5 BBS4 TBC1D4 EXOC1 NUP133 IFT172 CEP97 EXOC7 LZTFL1 IFT88 TTC30A;TTC30B GLB1 NUP88 BBS2 BBS1 SSNA1 FUZ IFT20 TTC26 IFT52 ARHGDIA DYNC2I2 DYNC2I1 BBS9 BBS7 DYNC1H1 SMC4 DYNC1I2 IFT57 CBS;CBSL COPS7B DYNLT1 AAR2 BBS5 IFT140 CTSA DYNLT2B EXOC6B AIMP1 IFT122 IFT80 EHD3 WNK1 RANBP10 HSPB11 MYL6B DOCK5 DYNC1LI1 TNKS1BP1 TMED1 IFT22 CNOT6L MCM2 EIPR1 IFT43 IFT74 IFT81 RAB3IL1 NME8 IFT27 MAPRE2 DYNLRB2 EXOSC7 DYNLRB1 PGRMC2 IFT46 EXOSC9 EXOSC2 WHRN TTC8 TIPRL-2 GID8 YPEL5 DGKE CLUAP1 APMAP ERF ARL8B CDH23 UBE2H TFAP2D CNOT10 LSM4 CNOT1 ZMYND19 RPGR RBM14 ARFGAP3 EHBP1 RAB21 RMND5B MYL6 DNPEP DCAF11 VAPB CAMK2A VPS4A AGPAT2 IQGAP2 NEK7 USH1C H3-3A EXOSC4 COX6C DCAF7 APC MCM4 NDUFA5 EFTUD2 UBE2D3;UBE2D2 TRAF3IP1 CD2BP2 RABEP2 MAEA ARMC8 LRPPRC POM121;POM121C COPS7A DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260810%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM ATF2 MRE11 BRCA1 TP73 CHEK2 CHEK1 NBN SMC1A CDC25C FANCD2 TRIM28 PRKDC MDM2-2 APAF1 PCNA E2F1 ABL1 CASP3 RAD52 RAD50 YAP1-1 RAD51 CDK5 BID TRAF6 STK3 EXO1 RAD17 TP53 ATM MCPH1 BAX RAD9A LATS1 ATR NABP2 UPF1 TERF2 BLM ACTL6A RNF8 BRCA2 CASP9 MDC1 TP53BP1 BAK1 CDKN2A RIF1 PARP1 KAT5 DCLRE1C RASSF1 SMC3 HSF1 LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260810%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 ACOT2;ACOT1 FADS1 ELOVL5 ACE2 ELOVL2 FADS2 SPINA BIFIDA%WIKIPATHWAYS_20260810%WP5150%HOMO SAPIENS Spina bifida MAT2B DNMT3B AHCYL2 MTHFD1 MTRR MTHFR MAT1A AHCY SHMT1 DNMT1 MTR-1 DNMT3A LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260810%WP4478%HOMO SAPIENS LTF danger signal response pathway TNF IFNB1-4 AGER NFKB1 IRAK1 IRAK4 IL6 CD14 IL1B TRAF6 IL1A MAPK1 LTF MYD88 TLR4 TLR2 CXCL8 TREM1 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP4970%HOMO SAPIENS Galanin receptor pathway CDKN1C CDKN1B CREB1 VEGFA CRP FOS SLC2A4 IL6 VAMP2 YAP1-1 PPARG INS;INS-IGF2 CDKN1A ADIPOQ POMC BCL2L11 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260810%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation NFKB1 TLR4 CTSB PYCARD NOX1 IL1B CASP1 DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260810%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor DGCR8 ATM MRE11 DDX1 RAD50 DROSHA NBN CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260810%WP4504%HOMO SAPIENS Cysteine and methionine catabolism CTH CDO1 CSAD AHCY CBS;CBSL MTR-1 GCLC GOT1-1 ETHE1 BHMT MAT1A MPST SQOR GSS SUOX NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260810%WP5398%HOMO SAPIENS NRXN1 deletion syndrome GRIN2C GRIN2D NRXN1;NRXN3;NRXN2 GRIA1 GRIA2 GRIN2A NLGN1 GRIN1 NLGN3 DLG4 NLGN2 GRIA3 GRIA4 NLGN4X;NLGN4Y GRIN3B GRIN2B GRIN3A 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5402%HOMO SAPIENS 10q22q23 copy number variation OPN4 GLUD1;GLUD2 ADAM10 ROPN1L RSPH6A SMC1A SH2D4B BUB1B ADIRF BMPR1A LDB3 MAT1A GHITM MAS1 STAG1 FAM25A;FAM25C;FAM25G;FAM25E-1 DYDC1 CDHR1 DYDC2 RGR GRID1 SNCG C10orf99 SF3B4 SUSD2 TSPAN14 IQUB LRIT2 SHLD3 LRIT1 PRXL2A SHLD2 NME5 SHLD1 SIRT4 CCSER2 ACTN2 RSPH9 ZMYND11 RSPH4A RSPH3 RSPH1 MMRN2 CEBPA TNFSF11 ERBB4 GPR15 VEGFA NFKB1 AFG3L2 PPARG MAD2L2 NRG3 PDS5B SMC3 PDS5A BMP2 RAD21 SH3GL3 WAPL DNAJB13 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260810%WP554%HOMO SAPIENS ACE inhibitor pathway CYP11B1;CYP11B2 TGFB1 CTSG ACE2 NR3C2 ATP6AP2 KNG1 BDKRB2 BDKRB1 ACE AGT AGTR1 NOS3 MAS1 REN AGTR2 CMA1 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260810%WP391%HOMO SAPIENS Mitochondrial gene expression PPRC1 GABPA CREB1 PPARGC1A MTERF3 MTERF1-1 POLRMT TFAM-1 HCFC1 MYEF2 PPP3CA SP1 NRF1 CAMK4 PPARGC1B GABPB1 ESRRA TFB1M TFB2M CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260810%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 SLC6A6 CARNS1 SLC15A4 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260810%WP404%HOMO SAPIENS Nucleotide metabolism PRPS1 POLD1 HPRT1 RRM1 NME2 PRPS2 POLB OAZ1 POLG SRM POLA1 MTHFD2 RRM2-1 RRM2B DHFR2;DHFR ADSL IMPDH1 ADSS2 SAT1 SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260810%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins CAV2 STX2 PRKCZ DAB1 RAP1GAP GPHN GABRG3;GABRG2 KCNJ6 GRIN2B KCNMA1 GABBR2 CADM1 STXBP2 TERF2IP ATP2B1 GRIK2 KCNQ2 CAMK2G NEO1 EFNA5 SNW1 CLSTN1 CLASP1 AGRN CHL1 EPB41L1 EPB41L2 NCDN CSN3 NTNG1 MAPK4 CADM3 APLP2 CASK GRIN1 PLCB4 ANK3 EPB41 CDH2 MAPK9 NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260810%WP288%HOMO SAPIENS Nod like receptor NLR signaling EPHB2 MAP3K7 CHUK ERBIN CD40 IKBKB MAPK8 RELA IKBKG ROTENONE METABOLISM%WIKIPATHWAYS_20260810%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260810%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway PKD1 TGFB1 LOXL4 FGF7 ANXA5 ECSIT COL2A1 NQO1 SIRT1 EXOC6 NFE2L2 IGFBP7 FN1 BMP2 SUV39H1 DDR1 NRF1 CDC37 HEART DEVELOPMENT%WIKIPATHWAYS_20260810%WP1591%HOMO SAPIENS Heart development PTPN11 FOXC2 HEY2 BHLHE40 FOXC1 NOTCH1 SMYD1 SMAD1 NFATC3 HAND1 NFATC1 FOXA2 NFATC4 SHH VEGFB FGF8 VEGFC MAPK1 TBX1 BMPR1A GATA4 TBX20 ERBB3 PITX2 SMAD4 MEF2C NKX2-5 IRX4 FOXH1 TBX5 HAND2 NFATC2 VEGFA BMP4 BMP10 SRF GATA6 FGF10 ISL1 BMP2 BMPR2 CTNNB1 TBX2 HEY1 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260810%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects ATF2 MAFA PPARGC1A TSC2 SLCO1C1 TSC1 SLC16A2 MC4R PRDM16 UCP1 NPY MTOR THRB NPPB MAP2K2;MAP2K1 FGFR1 PIK3CA GRB2 PNPLA2 MAPK1 RAF1 RPTOR RPS6KA6 RHEB PRKACA-1 NPR1 THRA HRAS MDM2-2 ITGB3 RPS6 MLST8 FOXO1-1 RPS6KB1 DIO1 ADCY3 ITGAV DIO3 PRKG2 CREB3 RXRA PFKFB2 ADCY8 SOS1 SIRT6 AKT3 TRH TBC1D4 BAD SLC5A5 TP53 SRC MAP4K5 DUOX2 SLC16A10 TSHR TTF2 TTF1 TG NHSL1 IYD DUOXA2 SECISBP2L SLC26A4 AKT1S1 FRS2 MAPK14 NOTCH1 GSK3B CASP9 TSHB KLB WNT4 SHH ZNF516 KDM3B TPO FGF21 POMC KDM1A PLIN1 PAX8 PPARG AGRP MGLL MAPKAPK3 ACTL6B CTNNB1 ITPR2 ADRB3 LOC100509620;LOC112267859;AQP7 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260810%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart PRKCB PRKCE MAPK14 MAP2K3 FOS RAC1 CTF1 MAPK11 CALM1 MYEF2 PPP3CA NFATC4 EDN1 RHOA PPP3CB MAPK1 AGT IL6ST LIFR GATA4 STAT3 CAMK2D MAPK8 JUN GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260810%WP2596%HOMO SAPIENS Gastric acid production PGA4;PGA3;PGA5 VIP SCT GAST PGC MUC6 CBLIF CCK GRP BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260810%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling GRIP1 PRKAA1 KSR1 TSC2 PIK3R2 PIK3R1 MTOR MAP2K2;MAP2K1 GRIA1 GRIA2 YBX1 EIF4EBP1 MAPK1 AKT1 RANBP9 RAF1 EIF4E GRIA3 MAPK3 SHC1-1 IRS1 NGF CREB1 CNR1 CYFIP1 IRS2 CAMK1 PTPRF DPYSL2 CDK5 PRKAA2 IGF2BP1 CFL1 ELK1 NTRK2 NTRK3 RAP1A GRIN1 SH2B2 CAMK4 MAPT FOXO3 PLCG1 ACACB NCK2 NCK1 RHOG GABRB3 LINGO1 CDK5R1 RAB3A EEF2 ADAM17 NSF CTNNB1 NCF1 NGFR SYN1 CDC42 NCF2 VAV2 TIAM1 SQSTM1 VAV3 STAT5A STAT5B EIF2S2 NFATC4 NFKBIA EIF2S1 GRB2 RACK1 SIRPA;SIRPB1;SIRPG JAK2 RPS6KA5 HRAS CAMK2A RPS6KA1 GRIN2B NCAM1 NTRK1 RPS6 PRKCD RPS6KB1 MAP3K2 CSNK2A1;CSNK2A3 CASP3 RAC1 TRAF6 BAD SRC SORT1 KIDINS220 RASGRF1 PTK2B FYN RELA JUN MAPK9 FRS2 PTPN11 MAPK14 FRS3 DOK5 APC KCNN2 DOCK3 GSK3B KCNA3 MAPK10 MARCKS IKBKB IKBKG MEF2A CHUK PDPK1 MEF2C MAPK8 PPP2CB;PPP2CA MAPK7 MAP2K5 MAP3K1 NFKB1 SHC4 CRTC1 SHC2 SH2B1 SHC3 CDKL5 STAT1 DLG1 STAT3 RPS6KA3 CDH2 BDNF NTF3 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260810%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MAPK14 IFNAR1 OAS1 RIPK1 IRF9 IKBKB IKBKG NFKBIA MAVS IKBKE MAP3K7 EIF2AK2 IFIH1 CHUK MYD88 MAPK8 DDX58 TYK2 FOS NFKB1 IRF3 TRAF3 TRAF6 STAT2 TBK1 JAK1 TLR7 IFNAR2 STAT1 OAS3 TICAM1 JUN CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260810%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies TNF CD4 ITGB7 IFNG ITGA4 IL15 F2RL1 GZMH;GZMB-1 DHODH IL21 EGFR IL2 TGM2 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260810%WP3945%HOMO SAPIENS TYROBP causal network in microglia ITGB2 ITGAX STAT5A GAL3ST4 TNFRSF1B DPYD C1QC NPC2 RPS6KA1 IL10RA LYL1 ABCC4 C3-1 PLEK ADAP2 ZFP36L2 HCLS1 TYROBP NRROS CD4 SPP1 LGALS9C;LGALS9;LGALS9B TGFBR1-1 RGS1 CD84 FKBP15 LOXL3 PYCARD CD37 RNASE6 APBB1IP BIN2 ELF4 SFT2D2 HLX TMEM106A TCIRG1 RBM47 CAPG IGSF6 KCNE3 SAMSN1 IL18 CYTL1 PPP1R18;LOC107987457 LHFPL2 MAF GAPT RUNX3 NCKAP1L IL13RA1 GPX1 SH2B3 SLC1A5 NCF2 ITGAM CREB3L2 SLC7A7 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260810%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder PRKAA1 PIK3CD SYNGAP1 PIK3R3 TSC2 TSC1 PIK3R2 PIK3CB ARC PIK3R1 MTOR PIK3CA EIF4EBP1 KRAS GRIN2A MAPK1 AKT1 RPTOR DLG4 RHEB SHANK3 NF1 HRAS MAPK3 GRIN3B GRIN2B GRIN3A RPS6KB1 AKT2 AKT3 NRAS PRKAA2 NTRK2 GRIN1 CAMK4 GSK3B HOMER1 GRIN2C GRIN2D PTEN PRKAG1 CAMK2B PRKAG2 GRM1 PRKAG3 PRKAB2 PRKAB1 UBE3A CACNA1C BDNF NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260810%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling GTF2F2 CCL8 CCL1 MTOR SRP54 EIF4EBP1 AKT1 IL9 EIF4E IL13 TLE3 CCNB2 CCL22 DEPTOR CCL27 CCL26 IFI44L CD3G CD3E CDK1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ZAP70 IL17A LCK CARD11 APOA2 CD4 IFIT1 MX1-1 HLA-DRA APOA1 CD247 IFITM3;IFITM2;IFITM1 CASP9 PRG3 CD2 NKRF NLRP3 NLRP1 CXCL12 TP53I3 IL18 CASP5;CASP4 APOC1 MAP1LC3B2;MAP1LC3B-1 GP1BA IFNG ATG13 IL18RAP CXCR2 G3BP1 IL1R2 FN1 CXCL2;CXCL3;CXCL1-1 ITIH4 APOD PTGS2-2 APOL3;APOL4;APOL1;APOL2 C1S C1R CFP IL33 NFATC3 C8A IL5 MAVS NEK9 IFIH1 RHEB JAK2 ATP6AP1 DDX58 NTRK1 TNF TGFBR2 CASP3 BIRC5 CRP RAC1 FGB IL10 FGA CCL23;CCL15 BID CCR5 FGG SERPINE1 IL1A SAA2;SAA1 CCL13;CCL2 AGT TOMM70 UPF1 FYN JUN AKT1S1 SKAP1 PRKCQ FGF2 IKBKG MAPK8 PMPCB IL7 CCL11 CCR6 CCNB1 AHR TRPM2 JAK1 PITRM1 STAT1 RRAS IL4 CXCL5;CXCL6 MMP25 SMAD1 SMAD5 DUSP1 IGLL5;IGLL1 ACTG1 PIAS1 MARK2 CAMK4 PF4;PF4V1-1 SELP HIF1A C1QBP TNFSF10 JUNB CCL20 IGFBP3 CTSV;CTSL LGALS3BP ITGA3 TPO CEBPB CXCR1 APOH IL6 TF HSPA8 TBK1 IL12A ACTB-1 ADAM9 MIB1 CCL3L1;CCL3L3;CCL3;CCL18 IRAK1 CFB VPS18 VPS33A CD14 GGH NFKB2 VPS11 CTSD VPS16 CXCL10 BST2 EIF4A2 RRM2-1 RPTOR MYD88 CTSB CXCL9 CD226 CXCL8 RPS6 CASP8 MLST8 GSN LBP LARP1-1 TRAF2 FOS VPS41 IRF3 TRAF3 IL1B ALB TRAF6 PARP2 TBKBP1 IL21 IL22 CXCL13 CCL21 SERPINA5 CCL4L2;CCL4L1;CCL4 CCL5 CFI IFNB1-4 ACE2 IRF9 CFH-3 PTPN6 CPN1 ITCH CD8A TLE1 CD8B;CD8B2 GTSE1 RTN4 VPS36 WDR74 BTN3A1;BTN3A3 APOM HP;HPR HRG CTSZ SDF2 ATP13A3-1 IL16 MOV10 OS9 SRP72 FAM83A INTS4 LRG1 SRP19 GABARAPL2 CLCC1 EGR1 G3BP2 NPTX1 STEAP3 MDN1 TRO TRIM59 ITIH3 RAP1GDS1 ERLEC1 UGGT2 ATE1 COL7A1 FAM98A SIGMAR1 DDIT4 ULK1 CD163 HBD;HBB NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260810%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis CASP3 CYCS-1 FADD CASP9 CASP7 BID ENDOG HTRA2 DIABLO-1 BCL2 FAS BAX BAK1 FASLG PRF1 CFLAR AIFM1 APAF1 CASP6 CASP8 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260810%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma PIK3CD PIK3R3 PIK3R2 PIK3CB PIK3R1 MAP2K2;MAP2K1 BRAF PIK3CA PRCC GRB2 KRAS CDKN1A MET MAPK1 AKT1 GAB1 RAF1 JAK3 PAK3 HRAS PAK2 MAPK3 PAK5 PAK4 KDR SOS1 RAC1 SOS2 TFE3 AKT2 AKT3 NRAS BAD RAP1B PTK2 RAP1A SRC JUN PLCG1 PTPN11 ALK CRK INSL3 MAPK8 HGF ELOA CBL VEGFA BUB1B-PAK6;PAK6 ETS1 RAPGEF1 CDC42 RPL11 PAK1 STAT3 C8orf34 ARAF CRKL STRN EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260810%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis DGCR8 ERI1 AGO2 DICER1 XPO5 DROSHA KALLMANN SYNDROME%WIKIPATHWAYS_20260810%WP5074%HOMO SAPIENS Kallmann syndrome PTPN11 ANOS1-1 FRS2 PROKR2 LHB TMEM98 OLIG2 ASCL1 MAP2K2;MAP2K1 FGFR1 PIK3CA SOX10 GRB2 FGF8 MAPK1 OTX2 AKT1 NEUROG1 SEMA3E PLXND1 PROK2 GNRH1 MYRF CHD7 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260810%WP1995%HOMO SAPIENS Effects of nitric oxide HBA2;HBA1 NOS1 AOX1 NOS2 NOS3 MB HBD;HBB XDH KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260810%WP5351%HOMO SAPIENS Kleefstra syndrome ACTL6A NR1I3 KDM6A KMT2C WDR5 ASXL1 BAP1 SMARCB1 SMARCD1 RXRA SMARCD2 SMARCD3 NCOA6 PAGR1 SMARCC1 SMARCC2 ARID1B PAXIP1 ACTL6B MBD5 SMARCA2 EHMT1 DPY30 ARID1A RBBP5 ASH2L H3-3A SMARCA4 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260810%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1C3 SULT6B1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT1B1-1 SULT4A1 PAPSS2 G6PD SULT2B1 PAPSS1 SULT2A1-4 SULT1C2 GSR ADIPOGENESIS%WIKIPATHWAYS_20260810%WP236%HOMO SAPIENS Adipogenesis SPOCK1 KLF7 RB1 SOCS3 PPARGC1A CELF1 PNPLA3 OSM EBF1 IRS4 PPARA NRIP1 PPARD IRS1 E2F1 NR2F1 FOXO1-1 GADD45B GADD45A CREB1 CNTFR IRS2 RARA CYP26B1 CYP26A1 WWTR1 RETN NCOA1 HIF1A SFRP4 LPL FOXC2 BSCL2 NDN SP1 INS;INS-IGF2 MEF2B;BORCS8-MEF2B CEBPA CEBPB WNT1 CEBPD NR3C1 KLF5 LIPE MIXL1 PLIN1 PCK1 KLF15 MIF PRLR BMP4 IL6 BMP3 LEP CTNNB1 RXRG PCK2 CFD STAT5A STAT5B EGR2 DDIT3 SLC2A4 TRIB3 UCP1 ASIP CDKN1A LIFR GATA4 HNF1A LIF TNF AGPAT2 RXRA SERPINE1 NAMPT STAT2 FAS AGT MEF2D BMP1 WNT5B SREBF1 RBL2 RBL1 PTGIS E2F4-1 DVL1 ID3 FZD1 LPIN1 CISD1 WNT10B LPIN2 MEF2A RORA IL6ST NCOA2 KLF6 LPIN3 MEF2C NCOR1 TGFB1 ZMPSTE24 DLK1 SCD NR1H3 IGF1 LMNA MBNL1 SMAD2;SMAD3 PPARG GATA3 GATA2 AHR SOCS1 STAT6 BMP2 ADIPOQ STAT1 NCOR2 STAT3 FRZB EPAS1 GTF3A GDF10 PLIN2 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260810%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol ACOT4 SLC27A5 IL25 IL17F DBP IL17D IL17C IL17B INSIG1 ESR1 CYP7B1 GPR183 CYP7A1 NR1I2 ACOX2 CYP46A1 EBP NR1H2 ACOT2;ACOT1 LBP CYP27A1 ESR2 DHCR7 CH25H HSD3B7 SULT2B1 RORC BAAT CYP39A1 SCP2 THEM5 IL17A ACOT9 ACOT8 EPHX2 ACOT7 HSD11B1 ACOT11 HSD11B2 ACOT12 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ACOT13 CYP8B1 AKR1D1 AMACR SULT2A1-4 ACOT6 SLC27A2 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260810%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction TNF ICAM1 IFNAR1 NFKB1 ACE2 TNFRSF1A NOX1 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260810%WP2001%HOMO SAPIENS miR targeted genes in adipocytes FADS1 LPL TGFBR2 SRSF10 HIPK3 CAP1 TMEM43 PICALM IGF2R CEBPB PHC2 ELOVL5 SRSF9 TMED10 CYP1B1 CSRP1 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260810%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets SPI1 TCF4 FLT3LG CSF1 BATF3 TPO ID2-1 CSF2 IRF8 IKZF1 IRF4 STAT3 RUNX2 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260810%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione GGCT DPEP1 GGT1 OPLAH GSS GCLC TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260810%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome TNF IFNB1-4 IFNG IL6 DDC IL1B KYAT3 AADAT KYAT1 GOT2-1 HAAO AHR KMO TDO2 KYNU AFMID IDO2 IDO1 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260810%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome GRM5 DBNL ARHGAP44 SHARPIN SYNGAP1 LZTS3 HOMER1 ITGB1 GRIA1 GRIA2 MAP3K7 TAB2 DLG4 CTNND2 SHANK3 ADGRL1 CAMK2A HRAS GRIN2B GRM1 ABI1 BAIAP2 HCN1 SPTAN1 RAP1A ACTB-1 GRIN1 CDC42 PAK1 DLGAP1 CTTN ITPR1 ARHGEF7}