SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors PIAS1 NR3C2 NR4A2 NR5A1 AR RXRA SUMO1 SUMO3 SUMO2 RARA PGR PPARG PPARA PIAS4 HDAC4 PIAS3 UBE2I THRB VDR NR1H2 RORA NR3C1 ESR1 NR2C1 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 97%1855231 Synthesis of IPs in the ER lumen MINPP1 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 97%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 ECHS1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 97%162589 Reverse Transcription of HIV RNA PPIA NEGATIVE TRANSCRIPTIONAL REGULATION OF UREA CYCLE ENZYMES%REACTOME DATABASE ID RELEASE 97%9988426 Negative transcriptional regulation of urea cycle enzymes CPS1 ARG1 TP53 OTC GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-HSA-1483206.8 Glycerophospholipid biosynthesis PLAAT1 PLA2G4A PLAAT3 PLAAT2 PLAAT5 GPCPD1 PLAAT4 HADHA PITPNM1 PITPNM3 PITPNM2 CSNK2A1;CSNK2A3 MGLL PLA2G1B AGPAT1 AGPAT2 ALPG;ALPP;ALPI-1 SELENOI AGPAT3 AGPAT4 GPAT4 AWAT2 GPAT3 GPAT2 CEPT1 CDIPT PLA2G10;LOC100652777 PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 MBOAT1 DDHD2 MBOAT2 DDHD1 ETNPPL GPAM LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 LPIN1 LPIN2 LPIN3 PNPLA2 LPGAT1 PITPNB CPNE7 CPNE6 LCLAT1 PLB1 PLA2G2A-1 LIPI LIPH JMJD7-PLA2G4B;PLA2G4B CPNE3 MFSD2A DGAT2 MIGA2 PCYT2 MIGA1 DGAT1 STARD7 CSNK2A2 GPD1L-1 PISD PLA2G15 ABHD3-2 GNPAT PHOSPHO1 GPD2 GPD1 CSNK2B PGP PLBD1 PLA2R1 PLA1A CDS1 ABHD4 CHAT PLD4 PLA2G3 PLD6 PLA2G5 PLD1 PLA2G6 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B CHKB OSBPL5 CHKA STARD10 DGAT2L6 CRLS1 PEMT CDS2 SLC44A5 ACHE SLC44A3 HADHB-1 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP TAZ OSBPL10 ACP6 AGPAT5-1 PCYT1B PLA2G12A PLA2G4F PCYT1A PLA2G4D PLA2G4E PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1251932 PLCG1 events in ERBB2 signaling EGF ERBB2 PLCG1 EGFR REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.5 Regulation of PLK1 Activity at G2 M Transition CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 PPP1CB MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC CEP290 YWHAG RAB8A SKP1 CDK5RAP2 HSP90AA1 OPTN-1 CEP135 PPP1R12A BORA FBXW11 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 AJUBA UBA52 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 RPS27A PCNT CEP76 CLASP1 UBB;UBC CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 97%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BCL2L11 BAD STAT3 BCL2 PMAIP1 BMF BID BBC3 BCL2L1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.6 Degradation of the extracellular matrix COL16A1 CTRB1;CTRB2 COL12A1 CAPN8 CAPN9 CAPNS1 CAPN6 CDH1 CAPNS2 CAPN7 BSG CAPN5 CAPN2 CAPN3 CAPN1 CAST PHYKPL COL23A1 ADAM10 HSPG2 BCAN ADAM17 ADAM15 OPTC ADAM9 ADAM8 COL17A1 COL13A1 HTRA1 PSEN1 NID1 KLK7 ADAMTS16 SCUBE3 NCSTN SCUBE1 ADAMTS18 A2M ELANE BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 LAMC2 LAMC1 CTSS MMP20 ADAMTS4 ADAMTS5 MMP25 MMP24 ADAMTS1 CTSK CASP3 TIMP2 KLK3;KLK2 CTSG TIMP1 ADAMTS8 CTSD ADAMTS9 CTSB CTSV;CTSL MMP7 COL25A1 MMP1 MMP2 MMP3 MMP8 MMP9 DCN MMP10 MMP12 MMP11 MMP14 MMP13 MMP16 MMP15 MMP17 MMP19 CD44 TPSAB1;TPSB2;TPSD1 LAMA5 COL15A1 TMPRSS6 LAMA3 FURIN PLG COL19A1 ACAN SPOCK3 SPP1 COL26A1 LAMB3 CMA1 LAMB1 CAPN13 CAPN14 CAPN11 PRSS3;PRSS2;PRSS1 CAPN12 CAPN10 TLL2 TLL1 KLKB1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.7 Epigenetic regulation of gene expression MGLL AGPAT2 GPAM LPIN1 PNPLA2 AJUBA RB1 SMARCB1 CCNH EHMT2 EHMT1 RRP8 LIPE H2AC14 TRIM28 SAP130 DPF1 PDK4 DPF2 DPF3 KAT8 MED1 SAP30BP SMARCC1 SMARCC2 ACSL1 HCFC2 MED4 MED6 MED7 HCFC1 WDR82 PAXIP1 PEX11A BAZ2A ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 OGT-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PPARGC1B CREBBP ZNF382 SETDB1 SS18L1 SETD1B SETD1A SMARCA5 SMARCA2 CIDEC SMARCA4 TADA2A ZZZ3 H2AC20 ZNF30 H2AB2;H2AB3;H2AB1 EZH1 EZH2 CBX3-1 PHF20 SUV39H1 PHF1 ASH2L SGF29 MED16 MED17 MED12 MED14 MED13 MED10 CD36 JARID2 NCOA1 NCOA2 SS18 NCOA6 ELOVL5 NCOA3 ACTL6A TET2 TET1 PPHLN1 MED27 BAZ1B SIRT1 MED23 PHF20L1 NCOR2 KAT2B H2AJ KAT2A NR5A2 NCOR1 MED24 AEBP2 TET3 MTF2 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 SF3B1 MBD3 SUZ12 H2BC5 MCRS1 MBD2 H2BC1 ZNF669;ZNF670 GTF2H1 GTF2H3 GTF2H4 GATAD2B GATAD2A FABP4 MYBBP1A MED31-1 MPHOSPH8 ZNF331 ARID4B TTF1 EP300 MTREX PHLDA1 MEN1 BOD1L2;BOD1 H2AC4 ADIPOQ SAP30 SPOCD1 TBL1XR1 ZNF317 ZNF354A;ZNF354B-4 ZCCHC8 KMT2D DNMT1 KMT2A KMT2C KMT2B BOD1L1 LPL MED30 TASOR ABL1 MBIP TASP1 SUDS3 ZNF324B;ZNF324 MORC2 DR1 CBX5 CDK8 CDK7 CDK5 YEATS2 ACTB-1 TADA3 MNAT1 PHF19 GSK3B PIWIL4 AKAP8L PSIP1 DPY30 UBE2I CHD4 CHD3 PAGR1 DNMT3L BCL7A SIN3B SIN3A H2BC21 BCL7C ZNF649 BCL7B UBTF DNMT3B RXRA WDR5 RBM7 KDM6A SUMO2 TBP EED DNMT3A H2AZ2;H2AZ1 ARID1A ARID1B ZNF264;ZNF805-1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H C19orf84 SMARCD1 CEBPA GTF2H2C;GTF2H2C_2;GTF2H2 SMARCD2 ACSS3 HDAC2 SMARCD3 HDAC3 DGAT2 UHRF1 HDAC1 CXXC1 DDX21 TAF1D MTA1 TAF1B RBBP4 TAF1C RBBP5 SAP30L TDG TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L SMARCE1 ATF7IP DEK EPOP H2BC15;H2BC3;H2BC11;H2BC12 KANSL1 ERCC3 KANSL2 SCD KANSL3 ERCC2 THRSP ERCC6 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides S100A8 LTF TLR2 DEFB129 DEFB128 DEFB127 DEFB106B;DEFB106A DEFB125 DEFB123 DEFB121 ART1 ITLN2;ITLN1-2 PDZD11 RNASE7 CHGA DEFB135 DEFB107A;DEFB107B S100A7A;S100A7 DEFB132 ATOX1 DEFB130B;DEFB130A DEFB105A;DEFB105B CD4 BPIFB2 BPIFB1 BPIFB4 BPIFB6 LCN2 DEFB103A;DEFB103B DEFB4A;DEFB4B ELANE PLA2G2A-1 CTSG EPPIN;EPPIN-WFDC6 PGLYRP4 PGLYRP3 PGLYRP2 LEAP2 LYZ-1 DEFB1 CLU DEFB109B BPIFA1 REG3G;REG3A-1 CCR6 ATP7A PGLYRP1 CAMP CCR2 PRSS3;PRSS2;PRSS1 DEFB131B;DEFB131A DEFB119 DEFA6;DEFA4;DEFA5 DEFB118 DEFB116 SLC11A1 DEFB114 RNASE6 DEFB110 TLR1 RNASE3;RNASE2-2 BPI S100A9 SOMITOGENESIS%REACTOME%R-HSA-9824272.2 Somitogenesis PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 RIPPLY2 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 MESP2 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 DLL3 PSMD8 LFNG PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 HES7 EPHA4 ADRM1 MSGN1 TBX6 PSMC2-1 PSMA2-1 PSMA5 SEM1 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196780 Biotin transport and metabolism HLCS MCCC1 PCCB ACACB ACACA MCCC2 SLC5A6 PDZD11 BTD PC PCCA SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport SLC44A4 SLC44A1 SLC44A2 SLC5A7 SLC10A6 SLC44A5 SLC44A3 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME%R-HSA-9605310.4 Defective Base Excision Repair Associated with MUTYH REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 YWHAB HSPA1A;HSPA1B HSPB1 ELAVL1 ZFP36 XPO1 KHSRP AKT1 UBA52 TNPO1 NUP214 DIS3 PRKCD PRKCA YWHAZ XRN1 MAPKAPK2 PARN ZFP36L1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 SET-1 EXOSC9 RPS27A EXOSC8 DCP2-1 EXOSC3 EXOSC2 UBB;UBC EXOSC1 HSPA8 PABPC1;PABPC3 MAPK14 ANP32A;ANP32D MAPK11 DCP1A EIF4G1 HEDGEHOG 'OFF' STATE%REACTOME%R-HSA-5610787.3 Hedgehog 'off' state IFT57 DYNC2H1 IFT140 RPGRIP1L KIF7 WDR35 RBX1 GNAS-1 IFT88 ADCY9 SMO PRKAR1B PRKAR1A GPR161 NUMB INTU ADCY4 ADCY3 TULP3 GSK3B ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 KIF3A TTC21B PRKAR2A CSNK1A1 PTCH1 PSMD12 WDR19 IFT122 PSMD11 FUZ PSMD14 ADCY10 PSMD13 ITCH MKS1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 PRKACA-1 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 CUL1 PRKAR2B RPS27A UBB;UBC OFD1-1 IFT172 GLI1 GLI3 GLI2 IFT52 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME%R-HSA-9939291.2 Matriglycan biosynthesis on DAG1 FKTN SLC35A1 SLC35A4 FKRP B4GAT1 CRPPA CHST10 DAG1 RXYLT1 LARGE1 LARGE2 POMGNT1 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 97%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) HDAC1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CHD3 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 ERCC6 GATAD2B GATAD2A H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CBX3-1 TTF1 H2AC4 EHMT2 HDAC2 H2AC14 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs RBX1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 SPRED3 PSMB2 SPRED2 PSMB3 RASA4;RASA4B PSMD2 SPRED1 PSMD3 SYNGAP1 PSMB1 PSMD1 HRAS RASA3 RASA1 RASA2 ADRM1 CUL3 RASAL1 PSMC2-1 RASAL2 RASAL3 PSMA2-1 PSMA5 NRAS DAB2IP SEM1 PSMA6 NF1 PSMC5 KBTBD7 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 RPS27A UBB;UBC ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation CFD C3-1 CFB HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162587 HIV Life Cycle PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 CD4 POLR2A NUP42 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B POLR2I RAE1 RANBP2 RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 UBAP1 NUP35 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 XPO1 UBA52 NUP214 GTF2H1 GTF2H3 GTF2H4 RPS27A UBB;UBC CDK7 MNAT1 PSIP1 TBP PPIA GTF2H2C;GTF2H2C_2;GTF2H2 CCNK NUP107 NUP188 CCNT1 GTF2B RCC1 BANF1 KPNA1 SUPT16H NUP210 POLR2E LIG1 LIG4 POLR2F GTF2F1 POLR2H GTF2F2 NUP93 CHMP4C CHMP4B POLR2L CHMP4A VPS28 NUP205 TSG101 NEDD4L AAAS GTF2E1 ERCC3 GTF2E2 NUP160 NUP85 TPR ERCC2 NUP88 SUPT4H1-1 XRCC6 NUP155 XRCC4 FURIN XRCC5 VTA1 NUP153 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 CHMP2A NMT2 TAF4B FEN1 ELL ELOC-1 TAF7L NUP62 ELOA NELFB ELOB CCNH NELFCD NELFA CCR5 NELFE NDC1 SEC13 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation GLB1L2 BCAN VCAN GLB1L GLB1 HYAL1 HYAL3 HYAL4 IDS CSPG5 GUSB ARSB DCN IDUA HEXB NCAN HEXA BGN GLB1L3 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%9909505 Modulation of host responses by IFN-stimulated genes CHUK UBA7 HSPA5 DDX58 EIF2AK3 ISG15 UBE2L6 IFI44L HERC5 IFIH1 IKBKB TRIM25 ARIH1 IKBKG ATF6 FKBP5 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 97%177504 Retrograde neurotrophin signalling NGF AP2A2 DNM1 DNM2 DNM3 AP2S1 DNAL4 SH3GL2 NTRK1 CLTC CLTA AP2A1 AP2B1 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 97%196299 Beta-catenin phosphorylation cascade PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C FRAT2 PPP2R1B APC PPP2R5E GSK3B CSNK1A1 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 97%9665251 Resistance of ERBB2 KD mutants to lapatinib CDC37 ERBB2 ERBIN HSP90AA1 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 97%8949664 Processing of SMDT1 MICU3 PMPCA MICU2 MICU1 MCU STOML2 MCUB SPG7 PHB MAIP1 PHB2 PARL AFG3L2 SMDT1 YME1L1 PMPCB KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9830369 Kidney development ITGB1 ROBO2 RET FOXC2 FOXC1 SIX1 CTNNB1 GATA3 PCDH19 HOXD11 FGF2 HOXC11 WFDC2 HOXA11 PLAC8 SALL1 WNT11 MECOM SIX2 HNF4A SLIT2 HOXA6 WNT4 IRX1 IRX2 EMX2 JAG1 EYA1 OSR1 WNT9B GFRA1 HNF1B NPNT PAX2 DLL1 POU3F3 GREM1 BMP4 PAX8 LFNG GDNF WT1 LHX1 ID4 ITGA8 HOXB4 SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 97%201556 Signaling by ALK FRS2 HDAC1 MYCN PIK3CA PTPN6 STAT3 SIN3A EP300 ALK CD274 IRS1 PIK3R2 PIK3CB PTN PLCG1 PRDM1 PIK3R1 IL2RG HIF1A PTPRZ1 DNMT1 MDK MYC HDAC2 ALKAL2 ALKAL1 HDAC3 JAK3 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 97%167152 Formation of HIV elongation complex in the absence of HIV Tat NCBP1 CCNK CCNT1 CDK7 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 NCBP2-1 CCNT2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9759811.1 Regulation of CDH11 mRNA translation by microRNAs TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 CDH11 AGO3;AGO1 TNRC6B RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 97%8951936 RUNX3 regulates p14-ARF KRAS RUNX3 RUNX1 HDAC4 BRD2 TGFB1 EP300 CCND1 CBFB BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 97%9018682 Biosynthesis of maresins CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 EPHX2 ALOX5 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665737.2 Drug resistance in ERBB2 TMD JMD mutants CDC37 ERBB2 ERBIN HSP90AA1 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors KCTD15 SUMO1 UBE2I TFAP2A WWOX TFAP2C TFAP2D KCTD1 TFAP2E;TFAP2B TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 97%8853884 Transcriptional Regulation by VENTX TNRC6C MOV10 TNRC6A-1 AGO4 CTNNB1 AGO3;AGO1 TNRC6B CCND1 CSF1R CEBPB ANAPC15 ANAPC16 LEF1 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 TP53 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 EHMT2 EHMT1 SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 97%9694516 SARS-CoV-2 Infection RPS14 GJA1 RPS17 TLR2 TBK1 RPS16 SNRPD2 RPS19 SNRPD1 RPS18 AKT2 AKT3 SNRPD3 RPS11 B2M RPS10 VPS39 RPS13 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ST6GAL1 MOGS ATG14 ACE2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 VPS11 ST3GAL4 SNRPE-2 SFN ST3GAL1 ST3GAL2 ST3GAL3 VPS16 SRPK2 EDEM2 PARP16 PARP14 SRPK1 PARP10 RPS25 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 NRP1 MAGT1 IKBKE YWHAE JAK1 TOMM70 PARP6 PARP4 PRMT1 RIPK2 SFTPD ANO8 ANO9 ANO6 TYK2 ANO4 PARP9 IL17RC ANO5 ANO2 PARP8 YWHAG IL17RA ANO3 ANO1 SIKE1 HSP90AA1 SMN2;SMN1 CANX TLR8 TLR7 ZDHHC20 TMPRSS2 RPS27L RNF135 RPS15A GPC1 MGAT5 YWHAB RPS3 GPC3 ANO10 GPC2 GPC5 MGAT1 AKT1 UBA52 GPC4 RPS2 NUP214 MGAT2 GPC6 STAT1 STAT2 SEC24D-1 YWHAZ MPP5 TJP1 NLRP12 ZDHHC9 STING1 IL17F FAU AGRN VCP-1 RPS27A CRB3 IL17A TUSC3 GEMIN2 UBB;UBC KPNA2 MAP3K7 RPS9 RPS7 RPS8 RPS5 VPS33A RPS6 VPS33B RPSA ZCRB1 GOLGA7-1 TUFM TMEM258 GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 GEMIN7 GEMIN8 ISCU IFNAR1 SNRPB DDX5 FUT8 TKFC IRAK1 IRAK2 MAN2A1 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 UVRAG CAV1 MAVS OSTC STT3A UBE2N TAB3 CSNK1A1 TAB2 STT3B TAB1 HSPG2 GSK3A ST6GALNAC2 HSP90AB1 PRKCSH MGAT4A-1 RPS4X YWHAQ YWHAH PDPK1 RPS3A DDOST LARP1-1 IRF3 DAD1 TRAF3 MBL2-1 TRAF6 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 NOD2 GANAB SNRPG-2 VHL CNBP-1 SEC24B IFNB1-4 SEC24A GALNT1 PTPN11 MGAT4C VPS41 NUP107 MGAT4B NUP188 VPS45 SEC24C CTSV;CTSL NUP210 NUP93 CHMP4C CHMP4B CHMP4A NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP155 FURIN NUP153 CHMP2B CHMP2A NUP62 RB1 NDC1 SEC13 NUP133 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 NUP42 CREBBP NUP43 RAE1 RANBP2 NUP35 NUP37 CHUK DDX58 ISG15 IFIH1 IKBKB TRIM25 IKBKG GSK3B UBE2I SUMO1 PTPN6 PATJ ZDHHC5 ZDHHC8 TLR1 ZDHHC2 ZDHHC3 RPS15 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome NCBP1 CDK7 GTF2A1 GTF2A2 CTDP1 MNAT1 RNMT TAF9 POLR2A POLR2B POLR2C POLR2D POLR2G TAF9B POLR2I TAF15 RNGTT TAF12 TBP TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNK CCNT1 GTF2B SUPT16H POLR2E POLR2F GTF2F1 POLR2H GTF2F2 POLR2L GTF2E1 ERCC3 GTF2E2 ERCC2 GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B ELL ELOC-1 TAF7L ELOA NELFB ELOB CCNH NELFCD NELFA NELFE REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 97%418359 Reduction of cytosolic Ca++ levels ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%629597 Highly calcium permeable nicotinic acetylcholine receptors CHRNB2 CHRNA2-1 CHRNA1 CHRNB4 CHRNA3 CHRNB3 CHRNA5 CHRNA4 CHRNA6 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding PFDN6 TUBAL3 GBA ARL2 GNA14 AP3M1 GNG10 STAT3 GNA15 GNG2 GNG5 GNG4 CSNK2A1;CSNK2A3 GNA11 GNG8 CCT8 TUBA3E;TUBA3C-1 CCT7 ACTB-1 CCT5 CCT4 NOP56 ARFGEF2 TBCD TBCC TBCB TBCA GNG13 CCT6A GNAQ GNB2 TBCE GNB1 PDCL GNB4 GNB3 SKIV2L FBXL3 GNB5 RGS11 FBXL5 TUBA8 WRAP53 TP53 HDAC3 TUBA1A CSNK2A2 CSNK2B TUBA4A DCAF7 CCT6B PFDN4-1 GNGT1 TUBA1C KIF13A TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 CCT3 FBXW4 CCT2 FBXW10;CDRT1 FBXW5 TUBB2B;TUBB2A VBP1 FBXW7 SPHK1 FBXW9 FBXW2 CCNE2 CCNE1 TCP1 XRN2 GAPDHS PFDN1 TUBB4B PFDN2 FKBP9 TUBB4A;TUBB;TUBB8B;TUBB8 PFDN5 TUBB3;TUBB6 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME DATABASE ID RELEASE 97%9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins TRIM28 HDAC1 MTA1 RBBP4 ZNF324B;ZNF324 CBX5 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 ATF7IP CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I CHD3 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 ZNF382 SETDB1 H2BC21 H2BC1 ZNF669;ZNF670 ZNF649 GATAD2B GATAD2A H2AC20 SUMO2 ZNF30 H2AB2;H2AB3;H2AB1 ZNF331 H2AZ2;H2AZ1 ZNF264;ZNF805-1 H2AC4 ZNF317 ZNF354A;ZNF354B-4 HDAC2 H2AC14 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579016.5 Defective UGT1A4 causes hyperbilirubinemia DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 97%5609977 Defective GALE causes EDG GALE INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies SI LCT PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 97%1912422 Pre-NOTCH Expression and Processing H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP H2BC21 NOTCH1 ST3GAL4 RBPJ ST3GAL3 H2AC20 H2AB2;H2AB3;H2AB1 LFNG B4GALT1 H2AZ2;H2AZ1 POGLUT1 MAML2 MAML1 POFUT1 PRKCI TMED2-1 SIRT6 TP53 TFDP1 ELANE ELF3 TFDP2 MFNG MAML3 NOTCH2 NOTCH3 NOTCH4 SEL1L RFNG E2F1 E2F3 ST3GAL6 RAB6A JUN SNW1 MAMLD1 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 KAT2B AGO3;AGO1 ATP2A3 H2AJ TNRC6B KAT2A ATP2A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 ATP2A1 RUNX1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 FURIN EP300 H2AC4 H2AC14 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 97%198765 Signalling to ERK5 MAPK7 MAP2K5 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 97%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SLC24A5 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 97%8848021 Signaling by PTK6 STAT3 NR3C1 EGF ERBB2 HRAS EGFR RASA1 HIF1A NRAS CDKN1B LRRK2 ARHGAP35 SFPQ-1 RAC1 PELP1 NRG1 CCND1 NRG2 ARAP1 RHOA EREG BTC DOK1 NRG3 NRG4 ELMO1 ELMO2 CRK DOCK1 HBEGF KHDRBS1 KHDRBS2 KHDRBS3 AKT1 UBA52 EPAS1 PXN CBL SOCS3 GPNMB STAP2 PTPN1 SRMS PTK6 CDK4 CDK2 BCAR1 RPS27A UBB;UBC CCNE1 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.3 SUMO is conjugated to E1 (UBA2:SAE1) SUMO1 SUMO3 SUMO2 UBA2 SAE1 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism PANK4 SLC5A6 PDZD11 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN1 VNN2 PPCS FASN ENPP2 ENPP1 SLC25A42 ENPP3 AASDHPPT INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%434313 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL4 ACSL3 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 97%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TYW1;TYW1B TRMT5 TYW3 TRMT12 LCMT2 TYW5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript NCBP1 NUP133 NXT1 U2AF1L5;U2AF1 EIF4A3 CASC3 NUP50 GLE1 POM121;POM121C NXF2;NXF2B;NXF5-1 THOC1 NUP54 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 SRSF3 NUP42 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A NUP43 POLDIP3 SRSF1 NXF1 U2AF2 RAE1 FYTTD1-1 RANBP2 DHX38 SRSF11 MAGOH;MAGOHB SRSF4-1 CHTOP ALYREF UPF3B RNPS1 NCBP2-1 NUP35 NUP37 NUP107 NUP188 NUP210 NUP93 NUP205 AAAS NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 NUP62 NDC1 SEC13 DEFECTIVE ABCD1 CAUSES ALD%REACTOME DATABASE ID RELEASE 97%5684045 Defective ABCD1 causes ALD ABCD1 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels MCOLN1 TRPC4AP MCOLN2 TRPV6 TRPV4 TRPV5 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPC3 TRPA1 TRPC4 TRPC1 TRPV2 TRPV3 TRPV1 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.8 Ligand-dependent caspase activation TICAM2 TRADD LY96 FASLG TRAF2 TICAM1 CASP8 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CD14 FADD TLR4 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation UBE2V1 UBE2N TAB3 TAB2 PSMD12 TAB1 PSMD11 PSMD14 PSMD13 PSMA7 PDPK1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 TRAF6 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 CDC34 IKBKB PRKCQ CARD11 BCL10 IKBKG RASGRP2 RASGRP1 MALT1 RASGRP4 LYN UBE2D3;UBE2D2 UBA52 NFKBIA CUL1 UBE2D1 RELA RPS27A UBB;UBC NFKB1 MAP3K7 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 97%9032845 Activated NTRK2 signals through CDK5 TIAM1 BDNF CDK5R1 RAC1 CDK5 NTRK2 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization GPNMB PTK6 EGFR LRRK2 HIF1A HBEGF DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 GCKR NUP155 GCK NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA MCM2 GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 GINS4 MCM3 MCM4 MCM5 MCM6 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer TGFBR1-1 TGFBR2 TGFB1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170968 Frs2-mediated activation FRS2 NGF MAP2K2;MAP2K1 RAP1A RAPGEF1 MAPK1 YWHAB BRAF MAPK3 CRKL FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654706 FRS-mediated FGFR3 signaling FRS2 FGF20 SOS1 FGF23 PTPN11 FGF2 HRAS FGF1 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters SLC34A2 SLC34A1 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8866423 VLDL assembly APOC1 MTTP APOC4 P4HB APOB REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 97%176408 Regulation of APC C activators between G1 S and early anaphase CDK1 BUB1B CDC20 FBXO5 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 ANAPC15 ANAPC16 CUL1 UBE2D1 ANAPC10 CCNB1 ANAPC11 CDK2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PLK1 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E UBB;UBC RPS27A UBA52 METABOLISM%REACTOME DATABASE ID RELEASE 97%1430728 Metabolism NR1H4 G0S2 NR1H3 GNMT AGMAT MKLN1 GATM ARSD-1 COQ8A N6AMT1 VKORC1L1 ADH1C;ADH1B;ADH1A TPMT RPL10A TM7SF2 PPP1CC MPC1 MPC2 SLC26A11 CSGALNACT1 RARS1 DIO1 CSGALNACT2 IPMK DIO3 KERA PGD SLC25A51;SLC25A52 RPE;RPEL1 CSNK1G2 IPPK SLC26A2 SLC26A1 INSIG2 INSIG1 HMMR MTM1 TPO MPC1L OSBPL9 COA3 RAB4A OSBPL7 OSBPL6 OSBPL3 OSBPL2 GCSH-3 M6PR PHKB SYNJ2 PUDP SYNJ1 NFYA-1 RAB5A RPL36AL-1 GAL3ST1 ADPGK AMD1 AZIN1-2 PIK3C2G PIK3C2A FTCD PIK3C2B IDH3B PRKG2 HMGCS2 LBR IDH3A COA5 ADSL GGPS1 CHPF2 FAAH2 APOA2 APOA1 APOA4 BPGM GSTT2B;GSTT2 APOA5 TST ALDH9A1 PDHB BPHL TTR BCO2 BCO1 ALOXE3 IDH3G CYP51A1 APOC3 BCKDK RAB14 VAPA VAPB PSAT1 CTH APOC2 SLC35B3 ISCA2 SLC35B2 ISCA1 MTRR GBA2 HS6ST1 HS6ST2 HS6ST3 CBS;CBSL RPL18A FLAD1 PDK3 CIAO2B SEPHS2 PDK2 PDK1 PDHX CPT1A SLC51A SLC51B CPT1B TIAM2 POR CYP2U1 MTHFD2L SUCLG2 SUCLG1 SLC22A4 RTEL1 SLC22A5 SLC35D1 STXBP1 SLC35D2 LHB TXN HELZ2 UGCG PRODH;LOC102724788 PYCR1 PYCR2 PYCR3 TYR DERA PM20D1 HAL LDHA;LDHC CYP2S1 C12orf73 CD320 GBE1 INS;INS-IGF2 SLC22A13 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 BHMT2 CYP7B1 DHFR2;DHFR UGDH ACBD5-1 NUDT11;NUDT10-1 DTYMK HAAO HDC GDPD1 LYPLA1-1 ZDHHC21 GDPD3 TYMS GDPD5 CYP7A1 PTS TYMP NT5C DUOX1 NT5E PDPR MTHFD1L SPTSSB NT5M CBR4 ACOT2;ACOT1 DUOX2 CBR3 ATP5PF ATP5PD PTGES2 NFYB ATP5PB NFYC GRHL1 PDP1 CYP2W1 PDP2 GSTA4 ATP5PO NDUFA13 NDUFA11 NDUFA12 NDUFA10 COMT CNDP2 CSKMT HADH RPL15-1 HGD NOSIP PNLIP IDI1 ISYNA1 IDI2 ALOX15 ALOX12 ATP5MJ ATP5MG ATP5ME MPST UQCC3 UQCC2 UQCC1 IDH1 IDH2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 COQ9 COQ7 GSTA3;GSTA1 COQ6 COQ5 GLUD1;GLUD2 SEPSECS COQ3 GRHPR COQ2 AMACR DAO PXMP2 PI4KA CRYL1 PI4KB LRP10 LRP12 GLP1R DBH OPLAH HK2 HK1 HS2ST1 HK3 CYP2R1 DBT DCK PRODH2 LSS DDAH1 DCT THRAP3 ALDH1A1 RBKS VAC14 PDXK DDC ETFDH DDO UGP2 ALDH1B1 FAM120B PDSS2 CHSY3 PDSS1 NOS3 LUM CHSY1-1 ST20-MTHFS;MTHFS UXS1 IL4I1 AS3MT NSDHL ALDH3B2;ALDH3B1 TDO2 LRAT XYLB STARD3 STARD4 STARD5 STARD6 UPB1 RUFY1 RBP4 SLC5A8 RBP2 ETHE1 RBP1 UQCRC1 UQCRC2 IDO2 HPD IDO1 MTMR1 HACD1 MTMR2 HS3ST3A1 MTMR3 RETSAT ABCB7 RPL10;RPL10L-1 ABCB4 MTMR8 MTMR9 IQGAP1 MTMR4 HACD3 HACD2 OAZ1 MTMR6 HACD4 MTMR7 SLC5A5 HSD11B1 HSD11B2 UGT8 CYP2B6 CYB5R3 HAO1 GPIHBP1 ABCA1 GLYATL3 B3GALNT1 CS BHMT UCK1 NOSTRIN ARF1 QPRT RPLP0 ECSIT AACS TRMT112 B3GALT2 B3GALT1 RPLP2 RPL36-1 ELOVL1 ARG2 ELOVL4 ELOVL2 PGAM1 PGAM2 ELOVL3 SIRT4 SIRT5 ELOVL6 ELOVL7 PTGR2 SUMF2 SUMF1 SIRT3 BDH2 BDH1 DLD VAMP2 GOT2-1 FH DMAC2 KARS1 UCP1 PET117 PTGS1 CYCS-1 EXTL2 UCP3 HAS1 UCP2 CARNS1 HAS3 HAS2 CYP2F1 GC EXTL3 MDH1 GK AADAT MDH2 FABP9 GSTM1;GSTM2-1 FABP1 LETM1 FABP2 LYRM2 FABP3 HSD3B1;HSD3B2 AADAC FABP5 LYRM4 FABP6 FABP7 LYRM7 RPL22L1 PECR HNMT SAT1 HMGCS1-1 STK11 HPGDS OSBP RPL37A-1 SLC25A44 EPM2A PIPOX SULT2A1-4 KPNB1 PFKFB2 PFKFB1 PFKFB4 PFKFB3 CYP19A1 ACAT2 ACAT1 SLC9A1 DSEL PMVK THEM5 THEM4 HACL1 SRD5A2 SRD5A1 SRD5A3 B3GALT4 B3GALT6 B3GALT5 GGCT SLCO1A2 UST SLC25A2 COX4I1 COX4I2 FHL2 PIK3CD PIK3CG NADK2 DSE ME1 ME3 ME2 UPP1 ARNT NDUFC1 SLC25A15 SLC25A18 SLC25A17 SLC25A19 RPL13A-1 SLC25A10 SLC25A12 SLC25A4 SLC25A11 ST6GALNAC5 SLC25A14 SLC25A13 ST6GALNAC6 NDUFB9 NDUFB8 NDUFB7 NDUFB6 PPM1L LRP1 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 HSD17B13 HSD17B12 PPM1K LRP2 HSD17B11 LRP8 HSD17B10 SLC25A27 CKMT2 SLC25A28 PCBD1 SLC25A21 D2HGDH IARS1 SLC25A20 SLC25A22 NDUFA9 CYB5A NDUFA8 NDUFA7 NDUFA6 MMAA MMAB NDUFA4 NDUFA3 RPL23A DHODH SLC25A37 TMLHE NT5C1A SLC25A32 AHCYL1 TXNDC11 NUBP1 NUBP2 ACAD11 ACAD10 PTGR1-1 ARSA ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 ASRGL1 PPP1R3C STX1A MMADHC GCDH PIK3R3 PHYH-4 PIK3R6 PIK3R5 ARSL ARSJ ARSK ARSH ARSI ST8SIA5 ARSG RIMKLA RIMKLB HMGCLL1 CTSA SURF1 ADHFE1 TPTE;TPTE2 PAICS ACER2 ACER1 TH RPL27A ACER3 RGL1 MOGAT3 MOGAT2 MOGAT1 TECR AKR1B1 WASL HSCB ARV1 SPTLC1 ACADL SPTLC3 HYAL2 MLX CD38 ACADM ACADS AASS ACAD8 VKORC1 STARD3NL ACAD9 AKR1A1 NT5C1B;NT5C1B-RDH14 CYP2J2-1 INPP1 AKR1D1 RXRB GCH1 PLEKHA1 NUBPL PLEKHA2 GCGR ACAA1-1 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 PPP1CA SULT1B1-1 PLEKHA8 ALDH4A1 ACAA2 EHHADH-1 CPOX CYP46A1 DUOXA1 DUOXA2 SBF1 GGT1 SBF2 G6PD MAT1A DPEP2 DPEP1 ATP5MC2 ATP5MC3 FUT2 FUT1 FUT4 ATP5MC1 EBP FUT7 FUT9 CYP11A1 CYC1 NDUFV3 NDUFV2 NDUFV1 GGT5 FDPS GGT7 GGT6 SLC52A3 QDPR GCLC GCLM CHD9 DNPH1 GPHN GAPDH-1 CPT2 UQCRFS1 A4GALT SULT4A1 HS3ST3B1 BCKDHA GLRX5 BCKDHB ABHD14B DARS1 LMBRD1 NDUFS8 NDUFS7 NDUFS6 CHDH NDUFS4 NDUFS3 BLVRB NDUFS2 MVD NDUFS1 PNP-1 BLVRA PAOX MVK MAT2B SAMHD1 CYGB HMGCL MAT2A AK4-1 MBTPS1 RPIA CYP24A1 RPL26L1 MBTPS2 PNMT RPL4 GOT1-1 RPL30 RPL3 RPL32 RPL31 GLDC RPL34 ENO1 ENO2 RPL8 ENO3 RPL9 RPL6 ENO4 RPL7 FDXR PLCE1 CYP1B1 RPL35 PIP4K2A RPL38 PIP4K2B MMUT PIP4K2C RPL39 ACOT9 CUBN ACOT8 MECR ACOT7 RPL21 RPL23 GLCE RPL22 MED8 MED9 HOGA1 CLPS CKMT1A;CKMT1B FDX1 RPL24 NHLRC1 RPL27 HPRT1 RPL26 RPL29 RPL28 ACOT4 CHST11 CHST12 PNPO CHST15 SLC19A3 PLCG2 CHST13 CHST14 SLC19A1 SLC19A2 CDK19 MTHFR RPL3L FA2H SLC6A7 SLC6A8 OGDH CYP1A1 PLCH1 PLCH2 ADA RPLP1-2 ADK ADO SERPINA6 PFAS TMEM186 PIP4P1 IMPA1 IMPA2 RFK LDLRAP1 MIOX ITPK1 TIMM21 BAAT ITPKB TMEM177 ITPKC PLCB3 PLCB4 IVD ITPKA PLCB1 PLCB2 RRM2-1 OCA2 ASAH1 ASAH2 RPL11 RPL14 SC5D RPL13 RPL18 RPL17 RPL19 AOC3 AOC1 AOC2 TIMMDC1 FMO1 FMO2 NMNAT3 FMO3 NMNAT2 AGT FIG4 NMNAT1 FMOD PLCD3 PLCD4 PLCD1 CHRM3 CHPF AHR FABP12 ABHD10 MAEA NAGLU IYD CHP1 GYG2 GYG1 AIP CACNB2 CACNB3 CEMIP FECH GLO1 AK1 ASMT AK2 ITPR1 ITPR2 MRI1 ITPR3 AK5 ABHD5 CYP4F22 AK6 AK7 AK8 AK9 ESD PSAP ESRRA SLC37A1 ASNS DHCR24 TECRL ALB SERINC1 DHCR7 SERINC3 SERINC2 SERINC5 SERINC4 GADL1 RPL7A GM2A SLC37A4 AMN GPX1 UGT1A1;UGT1A6 GPX4 AMT SORD ADRA2C INMT ADRA2A SARS1 ASPA ACSS2 GLS2 TYRP1 GLRX ACSS1 KCNJ11 TXNRD1 RPL35A PTPN13 ASS1 PFKL MARCKS IMPDH1 IMPDH2 FOLR2 CDO1 PFKM MMACHC PFKP SLC46A1 FAAH HPSE2 ACSM3 ACSM1 GDE1 ACSM5 MTR-1 ACSM4 NADSYN1 CHAC2 CHAC1 PTGDS GLUL SACM1L CMC1 ACSL6 SLC6A12 ACSL5 SLC6A11 CMBL INPP4A CYP27A1 PLPP6 INPP4B OXCT1-1 VDAC1 PLPP3 PLPP2 ALDH7A1 PLPP1 PTGES ACY1;ABHD14A-ACY1 SMIM4 MAOB MTARC2 MAOA MTARC1 MGST3 MGST1 MGST2 INPP5B CYP27B1 DGUOK SGPL1 INPP5A INPP5F NDUFC2;NDUFC2-KCTD14 INPP5D INPP5E INPP5J NAALAD2 INPP5K SCAP ASL TRAP1 CBLIF CIDEA ALOX15B ACADSB STAR STAB2 HCCS GYS2 GYS1 GLIPR1 QARS1 AUH NNT GUK1 ANKRD1 TNFAIP8L1 TNFAIP8L3 FFAR1 TNFAIP8L2 DLAT MANBA NME2 AMPD1 NME3 AMPD2 AMPD3 NME1 NME6 B3GNT7 B3GNT5 B3GNT4 FAM20B B3GNT3 B3GNT2 ALDOC ALDOB ALDOA UMPS PPA1-1 SPAM1 COX7A2L-1 ALOX12B UQCR11 AKAP5 UQCR10 ARNTL ATP5F1A ATP5F1B CA12 ARNT2 OLAH NQO1 NQO2 SCD5 RANBP9 FAH ATP5F1C LYVE1 ATP5F1D CA14 PSPH CA13 SPNS2 OCRL DCTD ALDH3A1 OXA1L CMPK1 ABCG2 COX7A2 ADIPOR1 ADIPOR2 HSPA9 ACBD7 ACBD6 ACBD4 EPHX1 TMEM126A-1 AZIN2 ACSF3 NMRAL1 ACSF2 MAN2B2 MAN2B1 ABCD4 B4GALT2 B4GALT3 ACADVL ABCD3 SLC2A1 SLC2A2 DHTKD1 SGSH ALDH2 CA5B PLCZ1 CA5A KYNU NAPRT CYP4V2 AOX1 MAN2C1 TSHB HIBCH PSTK ABCC3 ABCC1 ABCC2 PTGIS ABCC8 DCXR ABCC5 MARS1 CTPS2 CTPS1 HPDL HKDC1 PXYLP1 LALBA B4GALT6 B4GALT7 B4GALT4 B4GALT5 PON3 PTGES3-1 HPGD PON2 GMPR2 PON1 PRELP LTC4S RMND5B RMND5A BPNT1 B3GAT3 B3GAT2 B3GAT1 SGPP2 SGPP1 POMC PIKFYVE GNPDA1 GNPDA2 ALOX5AP SCLY PIAS4 UBE2I VDR NR1H2 RORA RXRA SUMO2 PPARG PPARA MINPP1 ECHS1 CPS1 ARG1 TP53 OTC LPGAT1 PITPNB CPNE7 CPNE6 LCLAT1 PLB1 PLA2G2A-1 LIPI LIPH JMJD7-PLA2G4B;PLA2G4B CPNE3 MFSD2A DGAT2 MIGA2 PCYT2 MIGA1 DGAT1 STARD7 CSNK2A2 GPD1L-1 PISD PLA2G15 ABHD3-2 GNPAT PHOSPHO1 GPD2 GPD1 CSNK2B PGP PLBD1 PLA2R1 PLA1A CDS1 ABHD4 CHAT PLD4 PLA2G3 PLD6 PLA2G5 PLD1 PLA2G6 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B CHKB OSBPL5 CHKA STARD10 DGAT2L6 CRLS1 PEMT CDS2 SLC44A5 ACHE SLC44A3 HADHB-1 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP TAZ OSBPL10 ACP6 AGPAT5-1 PCYT1B PLA2G12A PLA2G4F PCYT1A PLA2G4D PLA2G4E PLAAT1 PLA2G4A PLAAT3 PLAAT2 PLAAT5 GPCPD1 PLAAT4 HADHA PITPNM1 PITPNM3 PITPNM2 CSNK2A1;CSNK2A3 MGLL PLA2G1B AGPAT1 AGPAT2 ALPG;ALPP;ALPI-1 SELENOI AGPAT3 AGPAT4 GPAT4 AWAT2 GPAT3 GPAT2 CEPT1 CDIPT PLA2G10;LOC100652777 PLA2G2F BCHE PLA2G2D PLA2G2E AGK PNPLA8 MBOAT7 MBOAT1 DDHD2 MBOAT2 DDHD1 ETNPPL GPAM LPCAT4 ETNK2 LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 LPIN1 LPIN2 LPIN3 PNPLA2 PLCG1 PPP1CB PRKACA-1 PPP2R1A HSP90AA1 UBA52 PRKAR2B RPS27A UBB;UBC CTRB1;CTRB2 PHYKPL HSPG2 BCAN CTSV;CTSL DCN CD44 ACAN PRSS3;PRSS2;PRSS1 LIPE PDK4 MED1 ACSL1 MED4 MED6 MED7 PEX11A CCNC-1 PPARGC1A PPARGC1B CREBBP CIDEC MED16 MED17 MED12 MED14 MED13 MED10 CD36 NCOA1 NCOA2 NCOA6 ELOVL5 NCOA3 MED27 MED23 NCOR2 NCOR1 MED24 MED20 PLIN2 ANGPTL4 PLIN1 GPS2 FABP4 MED31-1 EP300 ADIPOQ TBL1XR1 LPL MED30 MORC2 CDK8 SIN3A ACSS3 SMARCD3 HDAC3 SCD ERCC2 THRSP PDZD11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 MCCC2 SLC5A6 BTD PC PCCA HLCS MCCC1 PCCB ACACB ACACA AKT1 NUP214 PRKCA MAPKAPK2 GNAS-1 ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A B4GAT1 NUP107 NUP188 NUP210 NUP93 NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 NMT1 NMT2 NUP62 NDC1 SEC13 NUP133 NUP50 POM121;POM121C NUP54 NUP42 NUP43 RAE1 RANBP2 NUP35 RAN NUP37 IDUA HEXB NCAN HEXA BGN GLB1L3 GLB1L2 VCAN GLB1L GLB1 HYAL1 HYAL3 HYAL4 IDS CSPG5 GUSB ARSB DNM2 PPP2CB;PPP2CA PPP2R5D PPP2R1B PIK3R2 PIK3CB PIK3R1 PIK3CA CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 EPHX2 ALOX5 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 SDC4 SAR1B SDC2 SDC3 PIK3R4 ST3GAL4 ST3GAL1 ST3GAL2 ST3GAL3 PARP16 PARP14 PARP10 RPS25 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 PARP6 PARP4 PARP9 PARP8 RPS27L RPS15A GPC1 RPS3 GPC3 GPC2 GPC5 GPC4 RPS2 GPC6 SEC24D-1 FAU AGRN RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TKFC CAV1 HSP90AB1 RPS4X RPS3A PIK3C3 SEC23A SEC24B SEC24A SEC24C CALM3;CALM1 GNGT1 SPHK1 GAPDHS GBA GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ GNB2 GNB1 GNB4 GNB3 GNB5 GALE B4GALT1 ST3GAL6 PANK4 PANK3 PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN1 VNN2 PPCS FASN ENPP2 ENPP1 SLC25A42 ENPP3 AASDHPPT ACSL4 ACSL3 ABCD1 GCKR GCK RAP1A APOB NDST2 NDST1 SCP2 NDST4 NDST3 GSTK1 PRKAB2 SDS TSTD1 SECISBP2 CACNA2D2 PHKA1 PHKA2 CH25H MTHFD1 SCO1 MTHFD2 SCO2 LARS1 FAR1 FAR2 TMEM126B CLOCK SHMT2 SHMT1 CIAO3 CIAO1 RDH11 AGMO AFMID PIP5K1A PIP5K1B LTA4H PIP5K1C GSTM4 GSTM3 PRXL2B SFXN4 LGMN MTMR10 MTMR12 KCNC2 MTMR14 DPYS MED19 PRKAG2 MED15 MED18 SMPD3 MED11 SULT1C2 SMPD2 SMPD4 ATIC SMPD1 TSPO ENOPH1 CHST6 CHST7 GSTO2 SPHK2 GSTO1 MED26 MED29 PGM2L1 SLC7A5 MED22 MED25 SDHAF2 CYP21A2 SDHAF3 MED21 AGPS SDHAF1 DPYD CHST1 ACSBG1 SDHAF4 L2HGDH ACSBG2 CHST2 RAPGEF3 PPARD RAPGEF4 CHST3 SAMD8 OAT GSTP1 ODC1 DLST ABCB11 RIDA RPL12-1 KCNB1 BBOX1 GID4 GID8 CIAPIN1 CRAT KCNG2 SLC27A1 ALDH1L1 ALDH1L2 FADS2 UROD NUDT19 NEK1 NUDT16 NUDT15 NUDT13 FADS1 NUDT12 TPST2 ACLY TPST1 SMS SLC27A3 SLC27A2 SLC27A5 UQCRB GMPS GMPR GSTT1 NRF1 NPAS2 NDOR1 AMDHD1 PGK1 KDSR IP6K1 NADK IP6K3 IP6K2 AGXT2 UROS BMX G6PC1 UCKL1 G6PC2 G6PC3 UQCRQ SP1 OGN TBXAS1 ACO1 ADSS1 ACO2 HPSE ADSS2 OSBPL1A SNAP25 ALAS2 ALAS1 PTEN APIP ETFA ETFB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ALAD SPR PGM2 ACP5 PGLS UGT2A1 PGM1 CERS3 CERS4 CERS5 CERS6 FOLH1B;FOLH1 RRM2B BCAT1 AGXT FXN DCTPP1 SMIM20 CERS1 TNFRSF21 BCAT2 CERS2 PRPS2 PRPS1 PRKAA2 CARNMT1 NME4-1 ACSM2A;ACSM2B FOXRED1 SRM SRR AWAT1 PHKG1 PHKG2 SLC36A4 TSPOAP1 MID1IP1 CYP4B1 GSTZ1 SUCLA2 UROC1 NAGS DMGDH SLC23A2 CERK SLC23A1 ECI1 NUDT5 NUDT3 HYKK STS BPNT2-1 PPAT MFSD2B GALM-2 OMD TALDO1 BCS1L SLC52A1;SLC52A2 CYP39A1 PYURF PPA2 TRIB3 CES3 CES2 CES1 PTGS2-2 SLC45A2 NEU2 NEU3 BRIP1 APOM NEU1 B4GALNT1 APOE PCK1 DECR2 B4GALNT2 PCK2 DECR1 DMAC2L SLC10A1 SLC10A2 MED13L EXT1 AIMP1 BST1 CYP26A1 EXT2 AIMP2 ALDH6A1 NDUFAF6 EPRS1 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 KYAT3 NDUFAF3 KYAT1 NDUFAF1 GSTA3;GSTA5;GSTA1;GSTA2 NDUFS5-1 LDHAL6B ACY3 COX7B HIBADH CROT COX7C KHK THTPA NMRK2 NMRK1 PHGDH COX8A SREBF1 COX8C GAA SREBF2 APRT EEF1E1 AGL-1 AHCY MRPS36 HSD17B3 HSD17B4 FITM1 FITM2 CYP2C18-1 COX5B HSD17B7 HSD17B8 COX5A GNAI1 CYP17A1 GNAI2 HSD17B1 ORMDL2 HSD17B2 ORMDL3 XDH PNPLA7 ORMDL1 GCG COX6C CYP8B1 NUDT7 KCNS3 NDUFAB1 NUDT4;NUDT4B PNPLA4 PNPLA5 PNPLA6 CBR1-1 GDA TACO1 INPPL1 MSMO1 COX6A1 COX6A2 TXN2 AKR7A2 AKR7A3 PPIP5K1 PPIP5K2 ENPP6 COQ10A-1 ENPP7 ACOT11 ACOT12 ACOT13 SDHC SDHD KMO SDHA COX6B2 SDHB COX6B1 SHPK SULT6B1 COX19 UBIAD1 NNMT NDUFB10 COX15 NDUFB11 COX18 COX17 CACNA1A CACNA1D GLYAT CACNA1C HIGD1A CACNA1E AANAT DHRS7B COX11 COX14 COX10 SYT5 EEFSEC PDHA1 HIGD2A NAT1 DEGS1 DEGS2 COX20 GALK1 TNFAIP8 PODXL2 TAT ADAL TMEM223 CA1 CYP26B1 ACOXL AKR1B15;AKR1B10 CA3 CA2 CA4 CA7 CA6 CA9 CAD ACOX2 ACOX3 NAT8L FBP1 FBP2 GALT NAXE SLC3A2 PPOX NT5C2 GK2 POLD1 TGS1 CRYM HSD3B7 RRM1 FAHD1 HS3ST5 HS3ST6 SUOX HS3ST4 TTC19 HS3ST1 HS3ST2 GALC GALNS CYP11B1;CYP11B2 CARM1 SARDH NAXD GLA PI4K2B CDA XYLT2 XYLT1 GLS NAMPT GAMT SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ARMC8 MTAP PRKD3 HMBS PRKD2 PRKD1 ADPRM PI4K2A TPH2 TPH1 SDSL GNS ADH5 ACMSD LDHB ADH4 LDHA TTPA HMOX1 ST3GAL5 CGA HMOX2 LHPP FDFT1 NR1D1 MCAT SQLE RPL5-1 TCN2 ADI1 TCN1 PAH PPT1 MMS19 PPT2 FUT6;FUT5;FUT3 ITPA PYGB GPI MOCS2 MOCS3 PYGM GPT PYGL CSAD MCEE TK2 TK1 RAB5IF TPI1 COQ10B GCHFR MTF1 PLIN3 AHRR TKT GART MED28-1 WDR26 SGMS1 SGMS2 PAPSS2 PAPSS1 CYP2A13;CYP2A6;CYP2A7-1 SLC17A5 CKB LDLR CKM TPK1 RNLS GSS GLYCTK MOCOS SQOR PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%156580 Phase II - Conjugation of compounds PODXL2 SLC35D1 TPST2 MGST3 SLC35D2 TPST1 MGST1 UGP2 MGST2 MAT2B N6AMT1 GSTT1 TPMT MAT2A UXS1 HPGDS AS3MT ABHD10 SULT2A1-4 GSTA3;GSTA5;GSTA1;GSTA2 GSTK1 BPNT1 UGDH AHCY GGCT ESD UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GSTM4 UGT2A1 AKR1A1 GSTM3 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 GSTA4 UGT1A1;UGT1A6 GLYATL3 SULT1C2 COMT CNDP2 SULT1B1-1 ACSM2A;ACSM2B TRMT112 GSTO2 GSTT2B;GSTT2 GSTO1 GGT1 MAT1A GSTZ1 CYP1A2 GSTA3;GSTA1 ACSM1 ACSM5 BPNT2-1 SULT6B1 MTR-1 GGT5 ACSM4 MTRR NNMT GGT7 CHAC2 GGT6 CHAC1 GSTP1 GCLC GCLM GLYAT OPLAH SULT4A1 ABHD14B NAT1 GSTM1;GSTM2-1 GSS SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209931 Serotonin and melatonin biosynthesis DDC AANAT TPH2 TPH1 ASMT INFLAMMASOMES%REACTOME DATABASE ID RELEASE 97%622312 Inflammasomes HSP90AB1 TXN APP NLRC4 RELA MEFV BCL2 NFKB2 HMOX1 PANX1 PYCARD P2RX7 PSTPIP1 BCL2L1 AIM2 CASP1 TXNIP NLRP1 SUGT1 NFKB1 NLRP3 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 97%167826 The fatty acid cycling model SLC25A14 UCP1 SLC25A27 UCP3 UCP2 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 SKP2 UBE2S CDC16 ANAPC4 ANAPC5 RB1 ANAPC1 ANAPC2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.3 Cytosolic tRNA aminoacylation LARS1 MARS1 AIMP1 KARS1 SARS1 EEF1E1 AIMP2 EPRS1 AARS1 HARS1 RARS1 YARS1 WARS1 GARS1 DARS1 NARS1 FARSA CARS1 PPA1-1 TARS1 FARSB VARS1 QARS1 IARS1 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 97%8875555 MET activates RAP1 and RAC1 DOCK7 GAB1 MET RAP1A RAPGEF1 CRK CRKL RAC1 RAP1B HGF NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes NOTCH1 EGF PDGFA MAFK AREG NFE2L2 BCL2 CREBBP BCL2L1 EP300 SP1 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) NSDHL DHCR24 HSD17B7 SREBF1 SREBF2 CYP51A1 MSMO1 TM7SF2 CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA PTPN6 PTPN11 BTLA TNFRSF14 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 EEF1B2-1 EEF1G EEF1A1 EEF1D EEF1A2 EEF2 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190377 FGFR2b ligand binding and activation FGFBP1 FGFBP3 FGF22 FGF3 FGF10 FGF1 FGF2 FGF7 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 97%9834899 Specification of the neural plate border BMP4 CTNNB1 TCF7L1 WNT3A DLX5 POU5F1;POU5F1B PAX3 TFAP2A SOX2 PAX7 TFAP2C FGF4 ZIC1 MYB MSX1 TFAP2E;TFAP2B INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) TSC1 AKT2 AKT3 AKT1 TSC2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 97%71291 Amino acid and derivative metabolism RPS14 ASRGL1 RPS17 GNMT RPS16 AGMAT MARS1 GCDH RPS19 GATM RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 RIMKLA RIMKLB RARS1 DIO1 SDS DIO3 TSTD1 SECISBP2 TH RPL27A PSMD12 PSMD11 PSMD14 LARS1 PSMD13 SCLY TPO PSMA7 PSMD8 SHMT1 PSMB6 PSMB7 PSMD6 RPS25 AFMID RPS27 PSMB4 GCSH-3 PSMD7 RPS29 AASS ACAD8 PSMB5 RPS20 PSMB2 RPS21 PSMB3 PSMD2 RPS24 PSMD3 RPS23 PSMB1 PSMD1 RPL36AL-1 AMD1 ADRM1 AZIN1-2 PSMC2-1 PSMA2-1 FTCD PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 ALDH4A1 PSMC4 ENOPH1 PSMC1 MCCC2 DUOXA1 DUOXA2 TST ALDH9A1 MCCC1 SLC7A5 MAT1A RPS27L RPS15A RPS3 BCKDK UBA52 PSAT1 RPS2 CTH MTRR OAT QDPR ODC1 CBS;CBSL DLST RPL18A FAU RIDA RPL12-1 RPS27A SEPHS2 BBOX1 CRAT RPS9 BCKDHA RPS7 RPS8 BCKDHB RPS5 DARS1 RPS6 RPSA SLC22A4 CHDH SMS PAOX PRODH;LOC102724788 PYCR1 PYCR2 PYCR3 TYR HAL AMDHD1 RPL26L1 PNMT RPL4 GOT1-1 RPL30 AGXT2 RPL3 BHMT2 CAV1 RPL32 RPL31 GLDC RPL34 PHYKPL RPL8 HAAO HDC RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A DUOX1 APIP RPL39 DUOX2 RPL21 RPL23 RPL22 HOGA1 FOLH1B;FOLH1 CKMT1A;CKMT1B BCAT1 RPL24 AGXT RPL27 RPL26 RPL29 RPL28 BCAT2 RPL15-1 CARNMT1 HGD SRM SRR RPL3L SLC36A4 SLC6A7 SLC6A8 MPST OGDH GSTZ1 UROC1 NAGS DMGDH RPLP1-2 ADO HYKK GLUD1;GLUD2 SEPSECS GRHPR DAO PXMP2 IVD DBH SLC45A2 OCA2 DBT RPL11 RPL14 PRODH2 RPL13 RPL18 DCT RPL17 RPL19 AOC1 DDC FMO1 DDO AIMP1 AIMP2 ALDH6A1 EPRS1 IL4I1 KYAT3 TDO2 KYAT1 IYD HIBADH ETHE1 ASMT PHGDH IDO2 HPD MRI1 IDO1 EEF1E1 AHCY MRPS36 RPL10;RPL10L-1 ASNS OAZ1 SERINC1 SERINC3 SERINC2 SLC5A5 SERINC5 SERINC4 GADL1 RPL7A HAO1 AMT BHMT INMT SARS1 ASPA RPLP0 GLS2 TYRP1 RPLP2 TXN2 TXNRD1 RPL36-1 RPL35A ARG2 ASS1 CDO1 SIRT5 KMO DLD MTR-1 GOT2-1 NNMT KARS1 GLUL SLC6A12 GLYAT SLC6A11 CARNS1 AANAT EEFSEC AADAT ALDH7A1 TAT RPL22L1 HNMT SAT1 NAALAD2 RPL37A-1 SLC25A44 NAT8L ASL PIPOX SLC3A2 ACADSB ACAT1 CRYM QARS1 AUH SUOX SARDH SLC25A2 ECHS1 CPS1 ARG1 GLS TP53 OTC GAMT MTAP SLC25A15 TPH2 RPL13A-1 TPH1 SLC25A10 SDSL SLC25A12 ACMSD SLC25A13 NQO1 CGA FAH PSPH RPL5-1 ADI1 PPM1K PAH HSD17B10 CKMT2 PCBD1 SLC25A21 IARS1 GPT CSAD AZIN2 NMRAL1 RPL23A TMLHE DHTKD1 TXNDC11 SLC44A1 SLC44A2 PAPSS2 PAPSS1 KYNU CKB CKM TSHB HIBCH PSTK RPS15 SQOR SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 97%198745 Signalling to STAT3 NGF STAT3 NTRK1 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives PTGS2-2 ALOX5 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.4 Factors involved in megakaryocyte development and platelet production H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RAB5A PRKACA-1 DOCK7 MAFK RAC1 DOCK1 MYB HBG2;HBG1 KDM1A JMJD1C DOCK10 DOCK11 KIF5B KIF5A KIF21A CDK2 KIF21B PRKAR2B KIFAP3 KIF4B;KIF4A KIF16B KIF20A KIF20B ZFPM2 ZFPM1 GATA6 GATA5 AK3 GATA4 GATA2 KLC1 GATA1 PHF21A KLC4 KLC3 KLC2 RACGAP1 KIF3B MICAL1 KIF3C CARMIL1 NFE2 EHD1 ABL1 EHD2 KIF18A EHD3 KIF18B MAFG MAFF RCOR1 CBX5 DOCK6 PRKAR1B GATA3 DOCK5 PRKAR1A DOCK4 CDK5 DOCK3 DOCK9 DOCK8 KIF12 KIF11 KIF15 AKAP10 KIF19 CAPZB KIF13B HMG20B KIF1C KIF1B PRKACB-1 KIF3A KIF1A JAK2 PRKAR2A KIF25 KIF23 SIN3A KIF22 RBSN KIF6 KIF27 RAD51B KIF9 RAD51C KIF2A KIFC2 KIFC1 IRF1 IRF2 KIF2C KIF2B DOCK2 HBD;HBB AKAP1 CDC42 MFN1 MFN2 TP53 SH2B3 SH2B2 SH2B1 CABLES1 CABLES2 CENPE WEE1 KIF26A CAPZA1 KIF26B CAPZA2 HDAC2 IFNB1-4 HDAC1 VPS45 ITPK1 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion TREH GUCA2B CEL GUCA2A LIPF CHIT1 PIR AMY1A;AMY1C;AMY1B;AMY2A;AMY2B SI LCT PNLIP ALPG;ALPP;ALPI-1 CLPS GUCY2C PNLIPRP1 MGAM RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF2S3;EIF2S3B EIF2B1 EIF2S1 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation NOS2 HGS ATP6V1H UBB;UBC CORO1A RAB7A RAB5A KPNB1 VPS33B KPNA1 RPS27A UBA52 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020591 Interleukin-12 signaling TYK2 CA1 ARF1 P4HB RPLP0 GSTO1 GSTA3;GSTA5;GSTA1;GSTA2 PITPNA LMNB1 CNN2 HNRNPDL AIP CFL1 STAT4 IL12B JAK2 IL12A HSPA9 IL12RB1 PAK2 IL12RB2 IL10 SERPINB2 ANXA2 MSN MIF RALA-1 SOD2 TALDO1 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 CDC42 LCP1 PPIA MTAP JAK1 TCP1 CAPZA1 RAP1B REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity FBXL17 BACH1 SKP2 UBB;UBC CUL1 MAFK RBX1 SKP1 RPS27A UBA52 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC16A10 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC36A4 SLC7A9 SLC7A5 SLC3A2 SLC6A12 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC1A3 SLC3A1 SLC1A4 SLC7A11 SLC1A5 SLC6A20 SLC7A10 SLC1A6 SLC7A1 SLC1A7 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 97%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes PDK4 KAT8 MED1 ACSL1 HCFC2 MGLL MED4 MED6 MED7 AGPAT2 HCFC1 WDR82 PAXIP1 PEX11A CCNC-1 OGT-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PPARGC1B CREBBP SETD1B SETD1A CIDEC TADA2A ZZZ3 H2AC20 GPAM H2AB2;H2AB3;H2AB1 PHF20 LPIN1 ASH2L SGF29 MED16 PNPLA2 MED17 MED12 MED14 MED13 MED10 CD36 NCOA1 NCOA2 NCOA6 ELOVL5 NCOA3 MED27 SIRT1 MED23 PHF20L1 NCOR2 KAT2B H2AJ KAT2A NR5A2 NCOR1 MED24 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H2BC5 AJUBA MCRS1 H2BC1 FABP4 MED31-1 EP300 PHLDA1 MEN1 BOD1L2;BOD1 H2AC4 ADIPOQ TBL1XR1 KMT2D KMT2A KMT2C KMT2B BOD1L1 LPL MED30 ABL1 MBIP TASP1 DR1 CDK8 CDK5 YEATS2 TADA3 AKAP8L PSIP1 DPY30 PAGR1 H2BC21 WDR5 RXRA KDM6A H2AZ2;H2AZ1 CEBPA ACSS3 HDAC3 DGAT2 CXXC1 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 KANSL1 KANSL2 SCD KANSL3 THRSP RB1 LIPE H2AC14 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196849 Metabolism of water-soluble vitamins and cofactors NMNAT3 MMADHC BST1 NMNAT2 NMNAT1 ST20-MTHFS;MTHFS PDZD11 SLC25A51;SLC25A52 SLC5A8 THTPA NMRK2 MTHFD1 NMRK1 MTHFD2 SHMT2 SHMT1 PARP16 PARP14 PARP10 CD38 PARP6 PARP4 CYB5R3 AMN PARP9 QPRT PARP8 MCCC2 SLC5A6 GSTO2 BTD GSTO1 PC PCCA HLCS MCCC1 PCCB ACACB ACACA FOLR2 MMACHC SLC46A1 MTR-1 MTRR NADSYN1 NNMT SLC52A3 PANK4 FLAD1 PANK3 GPHN PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN1 VNN2 ALDH1L1 PPCS ALDH1L2 FASN ENPP2 ENPP1 LMBRD1 SLC25A42 MTHFD2L ENPP3 AASDHPPT NUDT12 CTRB1;CTRB2 CD320 NADK CBLIF SLC22A13 NAXE DHFR2;DHFR MMUT NT5E NAXD MTHFD1L CUBN NADK2 ACP5 NAMPT SLC25A19 PNPO SLC19A3 SLC19A1 SLC19A2 MTHFR TCN2 TCN1 LRP2 SLC23A2 SLC23A1 MOCS2 MOCS3 RFK CYB5A LDLRAP1 MMAA ABCD4 MMAB SLC52A1;SLC52A2 SLC2A1 SLC25A32 PRSS3;PRSS2;PRSS1 NAPRT AOX1 TPK1 RNLS ABCC1 MOCOS PDXK ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated PPP2R1B DUSP4 PPP2R1A DUSP3 MAPK7 VRK3 DUSP6 MAPK1 DUSP7 MAPK3 PPP2CB;PPP2CA PPP2R5D CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response IL10 ADAM17 IL6 FURIN MAPK14 CD163 PLK2 RHBDF2 MYH9 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 97%3700989 Transcriptional Regulation by TP53 AKT2 AKT3 CSNK2A1;CSNK2A3 CCNA2-1 CCNA1 PRKAB2 SCO2 SFN NLRC4 CASP1 YWHAE PRMT1 PRKAG2 PPP2R1A YWHAG G6PD YWHAB AKT1 UBA52 TSC2 TSC1 YWHAZ AURKA CCNB1 RPS27A UBB;UBC MAPK14 MAPK11 CENPJ CDK1 TXN PMAIP1 BID BBC3 YWHAQ YWHAH PIP4K2A PDPK1 PIP4K2B PTEN PIP4K2C RRM2B CCNK PRKAA2 CCNT1 SUPT16H GTF2F1 GTF2F2 PIP4P1 SUPT4H1-1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B ELL ELOC-1 BRIP1 TAF7L CCNE2 ELOA CCNE1 NELFB ELOB CCNH NELFCD EHMT2 NELFA EHMT1 NELFE CTDP1 TAF9 POLR2A PLK2 COX7B POLR2B POLR2C MDC1 CREBBP COX7C ATF2 POLR2D TP53RK NOC2L SGK1-1 POLR2G KAT5 TAF9B CHEK2 COX8A POLR2I CHEK1 TP63 COX8C DAXX HUS1 TAF15 PRKAB1 RRAGA TAF12 RRAGC TAF13 RRAGB TAF10 DDIT4 TAF11 RRAGD SSRP1 DNA2 RHNO1 PHF20 TAF8 E2F4-1 TCEA1 L3MBTL1 TAF7 MEAF6 COX5B MAPKAP1 PRDX2 TAF6 NUAK1 COX5A TFDP1 TAF5 PCBP4 TAF4 PRDX1 TFDP2 TAF3 TP53BP2 ATRIP TAF2 PRELID3A TAF1 BANP BARD1 PLK3 PRELID1 CRADD E2F1 GADD45A TPX2 COX6C RAD17 JUN ATM CDK12 CDK13 ATR TP73 CDKN1A BTG2 CDKN1B SETD9 PRKAG1 CHM GLS2 BRCA1 PRKAG3 RPTOR COX6A1 ING5 COX6A2 ING2 TXNRD1 AIFM2 CASP10 TNKS1BP1 PRMT5 BRD1 RMI2 CNOT6L RMI1 TOP3A FOS DDB2 MBD3 RAD51D BRPF3-1 PCNA WRN COX6B2 PLAGL1 PERP COX6B1 PMS2 GTF2H1 RICTOR GTF2H3 BRD7 GTF2H4 TIGAR GATAD2B RPA1 GATAD2A RPA2 MLH1 HIPK1 CDK2 PPP2CB;PPP2CA POU4F1 POU4F2 CYCS-1 HIPK2 TTC5 RPA3 EP300 CCNG1 PPP2R5C RAD1 PPP2R1B LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 MRE11 SESN3 SESN2 KMT5A NBN BNIP3L USP7 IGFBP3 USP2 CDC25C MSH2 FANCD2 KAT6A MAPKAPK5 SMYD2-1 BLM MDM2-2 NDRG1 NPM1-2 SLC38A9 BCL2L14 ZNF420 MAP2K6 CDK7 STK11 FANCI CDK5 BRPF1 CNOT10 FANCC CNOT4 MNAT1 CNOT6 RGCC TP53I3 CNOT7 BCL6 CNOT11 RHEB CHD4 CNOT1 CHD3 CNOT2 JMY CNOT3 PIN1 MDM4 RAD9B CNOT8 CNOT9 RAD9A PRR5 DYRK2 PPP1R13B PIDD1 EXO1 CASP6 TBP PPP1R13L MLST8 CARM1 CASP2 TOPBP1 COX4I1 ZNF385A COX4I2 RFC5 RFC3 RFC4 APAF1 GLS TP53 RFC2 RABGGTB RABGGTA RBL2 PRDM1 RBL1 BIRC5 TMEM219 PRKAA1 GTF2H2C;GTF2H2C_2;GTF2H2 RNF34 AURKB COX7A2L-1 TP53INP1 HDAC2 RBBP8 RFFL E2F7 E2F8 HDAC1 ARID3A PML MTOR TNRC6C RAD50 MOV10 BAX CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 TNRC6B FAS POLR2E CSNK2B TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A POLR2F POLR2H RBBP7 MTA2 POLR2L COX7A2 GPI ERCC3 ERCC2 CDK5R1 NDUFA4 CDKN2A CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism SLC6A7 GAMT SLC6A8 GATM CKB CKM CKMT2 CKMT1A;CKMT1B SLC6A12 SLC6A11 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602410 TLR3 deficiency - HSE TLR3 CHROMATIN MODIFYING ENZYMES%REACTOME%R-HSA-3247509.6 Chromatin modifying enzymes MORF4L1-2 SUPT7L BRMS1 KAT6B MORF4L2 HAT1 ENY2 TAF5L KDM4C-1 ATXN7 EP400 SMYD3 DMAP1 COPRS MRGBP RIOX2 TADA1 BRWD1 KDM5A KDM5B KDM5C VPS72 KDM6B MSL2 H2BC18 MSL1 KDM7A KDM3A KDM3B HDAC8 KDM4A KDM4B KDM4D USP22 MSL3-1 REST CLOCK NFKB2 PRMT1 PAX3 RPS2 KDM1A PHF21A RCOR1 HMG20B JAK2 SMARCB1 EHMT2 EHMT1 H2AC14 SAP130 KAT8 SMARCC1 SMARCC2 HCFC1 TAF9 OGT-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP ATF2 SETDB1 SETD1B KAT5 SETD1A SMARCA2 SMARCA4 TADA2A ZZZ3 H2AC20 TAF12 H2AB2;H2AB3;H2AB1 TAF10 EZH2 PHF20 SUV39H1 MEAF6 ASH2L SGF29 NCOA1 NCOA2 ACTL6A NCOR2 KAT2B H2AJ KAT2A ING5 NCOR1 AEBP2 PRMT5 BRD1 GPS2 MBD3 SUZ12 BRPF3-1 H2BC5 MCRS1 H2BC1 GATAD2B GATAD2A CDK4 ARID4B EP300 H2AC4 SAP30 TBL1XR1 KMT5A KMT2D KMT2A KMT2C KMT2B KAT6A SMYD2-1 MBIP SUDS3 DR1 BRPF1 YEATS2 ACTB-1 TADA3 MECOM DPY30 CHD4 CHD3 H2BC21 WDR5 KDM6A EED DNMT3A CARM1 H2AZ2;H2AZ1 ARID1A ARID1B SMARCD1 SMARCD2 HDAC2 SMARCD3 HDAC3 HDAC1 MTA1 HDAC10 RBBP4 TRRAP EPC1 RBBP5 SUPT20H SAP30L PRDM7;PRDM9 WDR77 JMJD6 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PADI3 CCND1 PADI2 SAP18 PADI4 PADI1 PADI6 RBBP7 PRDM16 MTA2 TADA2B MTA3 PHF2 SUV39H2 SMARCE1 SETD2 ATF7IP SETD3 SETD6 SETD7 H2BC15;H2BC3;H2BC11;H2BC12 PHF8 KANSL1 ING4 ING3 KANSL2 PRMT6 PBRM1 KANSL3 PRMT7 ACTL6B PRMT3 ASH1L SUPT3H TAF6L DOT1L RELA NSD3 NSD1 NSD2 BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 H2AC16;H2AC11 ELP6 KDM1B NFKB1 JADE1 ARID4A YEATS4 JADE3 JADE2 RUVBL2 RUVBL1 KMT5B ARID2 KDM2A KDM2B KMT5C ARID5B INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 BUB1B CDC23 CDC20 CDC26 CDC27 ANAPC7 BUB3 UBE2C MAD2L1 UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules SLC35D1 SLC25A4 SLC35D2 ARL2 PDZD11 SLC5A6 SLC35B3 SLC35B2 SLC35B4 LCN15 SLC35A1 LCN12 APOD SLC35A2 SLC35A3 SLC33A1 SLC35C1 ARL2BP LCN1 SLC27A6 SLC29A4 SLC28A2 SLC25A5 SLC29A1 SLC28A1 SLC29A3 SLC27A1 SLC27A4 SLC29A2 SLC28A3 SLC25A6 RND3 GTPASE CYCLE%REACTOME%R-HSA-9696264.2 RND3 GTPase cycle FLOT2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST TMOD3 PLEKHG5 TXNL1 ARHGAP35 SCRIB SEMA4F LEMD3 CKAP4 KTN1 NISCH VANGL1 CCDC88A PTPN13 DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 CAV1 DSG1 PKP4 RBMX EPHA2 PICALM PIK3R2 PIK3R1 CKB DDX4 ROCK1 TNFAIP1 RASAL2 ARHGAP5 RND3 ARHGAP21 MUC13 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants KIT BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins HPGD LTA4H ALOX5 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME DATABASE ID RELEASE 97%5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 97%9603505 NTRK3 as a dependence receptor BAX NELFB NTRK3 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 SLC9A2 SLC9A3 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 97%166020 Transfer of LPS from LBP carrier to CD14 CD14 LBP ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 97%9845619 Enhanced cleavage of VWF variant by ADAMTS13 ADAMTS13 VWF SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-HSA-9716542.4 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 ADD3 GJA1 UACA GNA13 TRA2B STOM PTK2B BUB1 CLASP2 SPEN LIMK2 LIMK1 HSPE1 FMNL3 SLC4A7 FMNL1 PPP1CC FMNL2 VIM PIK3R4 SFN RPS27 YWHAE CCP110 PPP1CB MAPRE1-1 DOCK7 LBR PPP2R1A YWHAG HSP90AA1 PPP1R12A CKAP5 VAPB PAFAH1B1 DYNC1I2 KDM1A DOCK10 DOCK11 KIF5B KIF5A VCP-1 CLASP1 KLC1 DYNC1H1 TIAM2 NDE1 KLC4 PLK1 KLC3 KLC2 RACGAP1 KIF18A DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 CDH1 CAPZB CAV1 ACBD5-1 HSP90AB1 KIF2A YWHAQ YWHAH PDPK1 KIF2C KIF2B DOCK2 CDC42 MFN1 MFN2 PIK3C3 CENPE VHL KLK3;KLK2 HGS CALM3;CALM1 RAB7A LMNB1 CFL1 PAK2 CCT2 DBT CCNE1 SLC1A5 H2AC14 CCT7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CCT6A MYH9 MTMR1 H2AC20 H2AB2;H2AB3;H2AB1 IQGAP1 NCOA2 CDKN1B ARHGAP35 RAC1 H2AJ ARAP1 RHOA ELMO2 DOCK1 H2BC5 H2BC1 MEN1 LAMTOR1 H2AC4 STEAP3 LETM1 CDC25C ABL1 ACTB-1 SRRM1 DDX39B PIN1 H2BC21 H2AZ2;H2AZ1 BIRC5 AURKB H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 TIAM1 RAPGEF1 MAPK1 MAPK3 FRS3 S100A9 S100A8 SOS1 PIK3R3 KDM4C-1 BUB1B CDC20 BUB3 MAD2L1 WASL SHMT2 DDX4 ROCK1 TNFAIP1 ARHGAP5 RND3 ARHGAP21 MUC13 FLOT2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F CTNNB1 LEMD3 CKAP4 KTN1 NISCH VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 DSG1 YWHAB PKP4 RBMX EPHA2 PICALM XPO1 PRKCD PRKCA YWHAZ ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 WASF1-1 TRIO TFRC WIPF1 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L MAPK14 MYLK PREX2 MAPK11 PREX1 WDR91 ANKFY1 CEP97 PRKCB FNBP1 STARD8 NDUFS3 MRTFA BCR DYNC1LI1 DYNC1LI2 MYL6 WDR81 DAAM1 NGEF CENPN-2 MIS12-1 CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 SKA2 ABR RHOT1 MYO6 NCKAP1L STARD13 JUP MCAM FAM135A NOX3 HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARPC1B ARPC1A ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 NUF2 EMD NUDC RRAS2 GMIP LRRC41 CIT INCENP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 CDC42EP1 VAMP3 PKN3 GPS1 KCTD3-1 CENPA FGD1 CENPC FGD2 FGD3 CUL3 LMAN1 FGD4 RASAL2 FGD5 CHN2 CHN1 FLNA STX5 YKT6 CENPT FARP2 FARP1 NUP107 CENPU USP9X KIDINS220 MCF2 WWP2 DEF6 WDR11 TMEM59 CENPF CENPH ABI2 TAOK3 CENPI TAOK1 SHKBP1 CENPK ABI1 CENPL CENPM GOPC FILIP1 AAAS PKN2 CENPO PKN1 CENPP NUP160 NUP85 CENPQ UHRF1BP1L NCF1 FAM13B PLXND1 NCF2 NCF4 FAM13A MSI2 STK10 SLK TPM4 TPM3 RALGAPA1 SWAP70 VRK2 FAM91A1 TEX2 ARMCX3 CLIP1 PHIP MAD1L1 RHOBTB3 LIN7B RHOBTB1 RHOBTB2 STIP1 DDRGK1 DVL1 STK38 DVL2 DVL3 PLXNA1 SEC13 ABL2 SRGAP3 SRGAP2 NUP133 SRGAP1 ARPC4 ARPC5 NDC80 COPS4 RANGAP1 NSFL1C ARPC2 ARPC3 COPS2 NOXA1 PLXNB1 NF2 MAP3K11 ZNF512B ACTC1;ACTG2 RASGRF2 SNAP23 ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 NCK2 SPDL1 NCK1 PLEKHG3 PLEKHG4 ACTR2 PLEKHG1 PLEKHG2 NUP43 PLEKHG6 ARFGAP3 NIPSNAP2 ARFGAP2 LCK RANBP2 DSG2 EVL PPP1R12B PFN2-1 SOS2 ROCK2 SRC SRF ROPN1;ROPN1B NSL1 PARD6B PARD6A SH3BP1 ARL13B SLITRK3 NHS SLITRK5 CSK RBBP6 WHAMM WASF2 WASF3 NUP37 RNF20 PPP1R14A PCDH7 CDC42BPB BAIAP2 CDC42BPA MYO19 PRC1 CPNE8 GOLGA3 BAIAP2L2 BAIAP2L1 OPHN1 TMPO ACTN1 KNL1 ZW10 SPATA13 BTK PFN1 CFTR GRB7 TMEM87A PTPN13 GARRE1 TWF1 KALRN MYL12B DSN1 SCFD1 SPTBN1 SCAI RCC2 STAM ZWINT CLTC PTK2 NET1 ANLN AHCTF1 FAF2 KIF14 SH3RF1 MTR-1 AKAP12 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 PPP2CB;PPP2CA RAC3 SPTAN1 GIT1 PPP2R5B NDEL1 PPP2R5A VAV3 PPP2R5D CCDC115 PPP2R5C RALBP1-1 PPP2R1B RHOG RHOH RHOF PPP2R5E CDC37 RHOC RHOD ERBIN VAV1 VAV2 RHOB CTTN RHOJ ARHGEF3 ARHGEF4 ARHGEF1 RHOU TAX1BP3 ARHGEF2 RHOV ARHGEF7 DBN1 ARHGEF5 RHOQ ITGB1 ARHGEF6 AMIGO2 WAS NOXO1 TRAK1 TRAK2 PAK1 PGRMC2 SAMM50 EMC3 CTNNA1 PAK3 DYNC1I1 PAK5 PAK4 BCAP31 GIT2 CAVIN1 MTX1 MYO9B MYO9A MPP7 DLC1 TRIP10 RAB9A JAG1 B9D2 ESYT1 SPC24 RAB9B SPC25 TJP2 AR ERCC6L RTKN PRAG1 ZWILCH BUB1B-PAK6;PAK6 ARHGDIG ARHGAP39 PMF1;PMF1-BGLAP ACTG1 ARHGAP44 SYDE2 SYDE1 ARHGAP42 BASP1 ARHGDIA PIK3R2 ARHGDIB KNTC1 ARHGEF40 CYBB PIK3R1 CYBA ARHGAP45 SGO1 ALDH3A2 SGO2 STAM2 CENPS-CORT;CORT;CENPS ARHGEF26 ARHGEF25 FRS2 ARHGEF28 ARHGAP19 PIK3CA ARHGAP18 ARHGAP17 ARHGAP15 TOR1AIP1 ARHGAP12 NCKIPSD ARHGAP22 ARHGAP20 MYH14 HMOX2 MYH11 RHPN2 ECT2 MYH10 CPSF7 ARHGEF39 ARHGAP29 MACO1 OCRL ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 PLD1 ARHGAP32 DIAPH2 ARHGAP31 PLD2 ARHGAP30 DIAPH3 DNMBP DLG4 ACTR3-1 SOWAHC ARHGEF10L RND2 RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 PLIN3 ARHGEF12 ABCD3 ATP6AP1 ARHGEF15 ARHGEF17 ARHGEF16 ARAP2 ARHGEF19 ARHGEF18 ARAP3 SENP1 ARHGAP10 ZAP70 CKB ALS2 PEAK1 PDE5A ITGB3BP CCDC187 RAP1GDS1 MOSPD2 ARHGAP11A-1 FAM169A DIFFERENTIATION OF T CELLS%REACTOME%R-HSA-9945266.2 Differentiation of T cells TPST2 GATA3 HDAC11 BMI1 ETS1 TNF YY1 IL4R HDAC4 DPY30 KLF13 CHD4 RING1 CHD3 IL13 MAF IRF4 CREBBP CCL3L1;CCL3L3;CCL3;CCL18 HDAC5 HDAC8 SATB1 HDAC9 NOTCH1 RNF2 HDAC6 HDAC7 TBX21 STAT6 SMARCA4 RBPJ WDR5 CBX8 STAT5A STAT5B CBX6 PHC2 PHC1 POU2F1 CBX4 MAML2 CBX2 MAML1 NFATC2 NFATC1 ASH2L POU2F2 PHC3 BATF IL4 IL5 MAML3 NOTCH2 HDAC2 HDAC3 HDAC1 JUN SNW1 MAMLD1 MTA1 HDAC10 RBBP4 NCOR2 RBBP5 KAT2B KAT2A NCOR1 RUNX3 RUNX1 RBBP7 MTA2 MTA3 FOS STAT4 MBD3 IL12RB2 GATAD2B GATAD2A IFNG EP300 MEN1 TBL1XR1 KMT2A NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration ACO1 IDH1 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 97%446210 Synthesis of UDP-N-acetyl-glucosamine NAGK AMDHD2 GFPT2 GFPT1 PGM3 GNPNAT1 UAP1 RENBP TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 97%5357786 TNFR1-induced proapoptotic signaling SPATA2 TNFAIP3 SHARPIN TBK1 USP21 USP4 MIB2 TNFRSF1A TRADD CYLD RBCK1 OTUD1 TRAF2 BIRC2 BIRC3 CASP8 OPTN-1 RIPK1 FADD TNF IKBKE RNF31 XIAP USP2 OTUD7B FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%201722 Formation of the beta-catenin:TCF transactivating complex HDAC1 TRRAP RBBP5 CTNNB1 H2AJ TCF7 CDC73 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TERT LEO1 BCL9L TLE4 RUNX3 TLE3 TLE2 TLE1 TCF7L1 AXIN2 PYGO1 DPY30 BCL9 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PYGO2 H2BC15;H2BC3;H2BC11;H2BC12 CREBBP H2BC5 H2BC21 H2BC1 KAT5 LEF1 SMARCA4 WDR5 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EP300 TCF7L2 ASH2L MEN1 H2AC4 RUVBL1 MYC KMT2B H2AC14 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins AQP5 AQP2 AQP3 LOC100509620;LOC112267859;AQP7 AQP1 MIP AQP8 AQP10 AQP9 AQP6 AQP11 AQP4 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME%R-HSA-5610783.2 Degradation of GLI2 by the proteasome PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 GSK3B PRKACB-1 CSNK1A1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 GLI2 PSMA5 PRKACA-1 SEM1 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 TBK1 TANK TICAM2 LY96 TICAM1 OPTN-1 TRAF3 RPS27A CD14 UBB;UBC TLR4 IKBKE UBA52 DIFFERENTIATION OF CIRCULATING MONOCYTES%REACTOME%R-HSA-9968734.1 Differentiation of Circulating Monocytes CSF1 IFNG N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 97%975576 N-glycan antennae elongation in the medial trans-Golgi LHB MGAT4C MGAT4B CGA B4GALT6 FUT8 B4GALT4 B4GALT5 MAN2A1 ST6GAL1 MGAT5 FUT6;FUT5;FUT3 ST3GAL4 MGAT2 MGAT4A-1 MAN2A2 MGAT3 B4GALT2 ST8SIA6 B4GALT3 CHST10 CHST8 B4GALT1 ST8SIA2 FUCA1 ST8SIA3 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 97%450294 MAP kinase activation UBE2V1 MAP2K6 IRAK1 IRAK2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 UBE2N ATF2 TAB3 TAB2 TAB1 TRAF6 NOD1 NOD2 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 CHUK FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC NFKB1 RPS6KA1 MAP3K7 MAP2K2;MAP2K1 MAP3K8 MEF2A MAP2K3 MAPK1 MAPK14 MAP2K4 MEF2C MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.14 Generic Transcription Pathway CSNK2A1;CSNK2A3 HDAC11 BMI1 YY1 RING1 MAF HDAC5 HDAC9 RNF2 HDAC6 HDAC7 CBX8 GPAM CBX6 PHC2 PHC1 CBX4 CBX2 NFATC2 PHC3 NFYA-1 ERBB2 EGFR YWHAE PRKACA-1 LBR PPP2R1A YWHAG SKP1 TCF7 UBA52 CUL1 AURKA CCNB1 RPS27A UBB;UBC MEF2C CENPJ SPI1 TGIF1-1 CDK1 ZNF287 ZNF18 RBFOX1 RBFOX3 BCL2L11 TXN ZNF282 ZNF10 ZNF12 CLDN5 PMAIP1 DDIT3 ZNF23 BID ZNF25 BBC3 GRIN2A ZNF268 ZNF263 ABCA6 NR2F1 NR0B2 GRIN2B NR2F6 COL1A1 INS;INS-IGF2 COL1A2 ZNF496 ZNF250 UCMA ZNF45 HEY1 HEY2 ZNF41 CTLA4 ZNF248 ZNF485 ZNF483 ZNF235 ZNF473 SERPINB13 ZNF470 HTT ZNF226 ZNF222 CR1L;CR1 ATAD2 ZNF77 ZNF79 SKI ZNF70 AGRP ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZKSCAN4;ZKSCAN3 ZNF692 ZNF691 NFYB RORC RORB NFYC ZNF689 ZNF205 ZNF446 ZNF688 ZNF445 PITX2 ZNF202 ZNF200 ZNF160;ZNF347;ZNF665-1 ZFP69B CTSK FOXP3 NPAS4 ZNF432 PVALB BLK GRIA2 MAX DLX6 FOXO4 FOXO3 CTSV;CTSL ATXN3 ZKSCAN8 ZNF668 ZNF667 ZKSCAN5 ZNF664 SOCS4 ZKSCAN1 ZNF662 ZNF660 FBXO32 ZNF419 MMP13 ZNF658 ZNF416 ZNF655 SP7 ITGAL DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 ITGA4 TNFRSF18 FURIN ZKSCAN7;ZNF852 PPM1A HAND2 ITGA5 SPP1 PPM1D YAP1-1 ZNF624 ZNF621 E2F5 E2F6 ZNF747;ZNF764 MGA TBX5 PINK1 SST SYT10 IL2RA ZNF615 ZNF614 RB1 ZNF613 SMARCB1 STUB1 CCNH EHMT2 PTPN4 EHMT1 TRIM33 UXT LGALS3 CCN2 H2AC14 TRIM28 ZFP1 ZNF713 ZNF711 ZNF710 L3MBTL2 FOXG1 TGFA ZNF707 MED1 ZNF706 SMARCC1 ZNF704 SMARCC2 ZNF703 HIVEP3 WWTR1 YES1 MED4 IQSEC3 MED6 ITGBL1 MED7 MSTN HNF4G FOXO1-1 SATB2 ZFP14 RXRG ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 GAD1 GAD2 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A CCNG2 PPARGC1B ZFP28 CREBBP IHH ZNF274;ZNF74 ZNF382 CCND3 CCND2 NPPA SETD1B MSX2 SETD1A GEM SMARCA2 GPRIN1 SMAD2;SMAD3 SMARCA4 ZFHX3 AUTS2 IL2 IL3 H2AC20 ZNF30 BMP2 LDB1 H2AB2;H2AB3;H2AB1 MYBL2 EZH2 RBM14 CBX3-1 TGIF2 ELF1 PHF20 ELF2 CAT RETN ASH2L ZNF804B MED16 ZNF175 MED17 SERPINE1 MED12 JUNB MED14 RNF111 MED13 ZSCAN25 MED10 ZNF157 ZNF398 ZNF394 NKX2-5 NR2C2AP ZNF383 ZNF140 CDC7 NR1D2 ACTL6A ZNF699-7 ZNF135 ZNF133 RARG MED27 BTG1 ZNF568-3 SIRT1 UBE2D3-1 MED23 RSPO3 TEAD1 TEAD2 NCOR2 TEAD3 KAT2B ZIK1 H2AJ TEAD4 KAT2A TCF12 PAX5 NCOR1 MED24 TAL1 RARB ZNF599 ZNF114 MED20 ZNF597 ZNF112 OCLN-1 ZIM2 ZNF584 GPS2 ZNF583 PCGF6 MBD3 ZNF582 CDKN2B SUZ12 H2BC5 PCGF5 PCGF2 WWP1 SIRT3 H2BC1 RYBP ZNF669;ZNF670 ZNF334 GTF2H1 ZNF573 GTF2H3 ZNF570 GTF2H4 CSF2 GATAD2B ITGA2B GATAD2A ZFP30 ZNF569 ZNF567 MED31-1 ZNF566 ZFP37 ZNF331 ZNF565 CYCS-1 ZNF563 IGFBP1 EP300 PF4;PF4V1-1 ZNF302;ZNF181 NRBP1 MEN1 ZNF311 ZNF793 ZNF792 H2AC4 ZNF791 KRBA1 ZNF549 ZNF548 TBL1XR1 ZNF317 ZNF546 ZNF354A;ZNF354B-4 ZNF304 ZNF786 KMT2D SKIL PLXNA4 KMT2A ZNF300 KMT2C ZNF782 KMT2B ESRRB ESRRG ZFP69 MED30 CDK6 ZNF777 ABL1 ZNF775 ZNF426-1 ZNF774 ZNF772 ZNF324B;ZNF324 ZNF771 ZNF770 ZNF529 ZNF521 CBX5 CDK8 ZNF75D CDK7 ZNF75A STK11 CDK5 ZFP90 CRH ZNF514 ZNF750 MNAT1 ZNF746 ZNF740 GSK3B KCNIP3 KLF4 RAD51 ZNF606 DPY30 ZNF605 CHD4 SOX9 CHD3 ZNF839 ZNF555;ZNF57;ZNF556 TWIST2 CITED1 SIN3B CITED2 SIN3A CITED4 H2BC21 PARP1 GP1BA ZNF649 ZNF3 ZNF350;ZNF432 ZNF557;ZNF558 NPY WDR5 CAMK4 LMO1 ZNF197;ZNF660-ZNF197 TBP LMO2 EED ATP1B4 LIFR KCTD6 H2AZ2;H2AZ1 ZNF124-4 ARID1A COX4I1 NOP2 ARID1B COX4I2 ZNF264;ZNF805-1 SMAD1 SMAD4 SMURF2 SMURF1 SMAD6 ESR2 SMAD7 NR4A1 NR4A3 THRA ARNT SMARCD1 NR2E1 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 OPRM1 SMARCD2 CAMK2B CAMK2D HDAC2 CAMK2A SMARCD3 NR2C2 HDAC3 THBS1 HSPD1 HDAC1 HES1 CAMK2G ZNF189 ZNF286A ZNF184 ZNF180 RBBP4 OPRK1 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 MTA2 POLR2L SMARCE1 DEK H2BC15;H2BC3;H2BC11;H2BC12 ERCC3 ERCC2 NDUFA4 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RXRB ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 G6PD YWHAB XPO1 AKT1 YWHAZ MAPK14 MAPK11 GLI3 GLI2 RBX1 ITCH PIP4K2A PIP4K2B PIP4K2C MED8 CCNK CCNT1 SUPT16H GTF2F1 GTF2F2 NEDD4L PIP4P1 SUPT4H1-1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B RRM2-1 ELL ELOC-1 TAF7L ELOA NELFB ELOB NELFCD NELFA NELFE CTDP1 TAF9 POLR2A POLR2B POLR2C POLR2D POLR2G TAF9B POLR2I TAF15 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TCEA1 ESRRA TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GLS2 TXNRD1 FKBP5 PPP2CB;PPP2CA AXIN1 PPP2R5C PPP2R1B RET GATA3 HNF4A JAG1 PRDM1 MYC COX7A2L-1 ARNTL TNRC6C MOV10 ARNT2 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B BRD2 TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 COX7A2 TFAP2A WWOX TFAP2C TFAP2D KCTD1 TFAP2E;TFAP2B KCTD15 CSF1R CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 AKT2 AKT3 POMC SFN NLRC4 CASP1 TXNIP SKP2 PRMT1 MET TCF7L1 DLX5 SOX2 MYB TSC2 TSC1 STAT1 TJP1 ZFPM1 GATA4 GATA2 GATA1 NFE2 IRAK1 CAV1 YWHAQ YWHAH PDPK1 PTPN11 CALM3;CALM1 SOD2 IFNG CCNE2 CCNE1 PLK2 MDC1 ATF2 TP53RK NOC2L SGK1-1 KAT5 CHEK2 CHEK1 TP63 DAXX HUS1 PRKAB1 RRAGA RRAGC RRAGB DDIT4 RRAGD DNA2 MAML2 RHNO1 MAML1 E2F4-1 L3MBTL1 MEAF6 MAPKAP1 PRDX2 TFDP1 NUAK1 PCBP4 PRDX1 TFDP2 TP53BP2 ATRIP MAML3 PRELID3A NOTCH2 NOTCH3 BANP BARD1 NOTCH4 PLK3 PRELID1 E2F1 CRADD GADD45A TPX2 RAD17 JUN ATM SNW1 CDK12 MAMLD1 CDK13 ATR TP73 CDKN1A BTG2 CDKN1B SETD9 PRKAG1 CHM BRCA1 PRKAG3 RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 PRMT5 BRD1 RMI2 CNOT6L RMI1 TOP3A FOS DDB2 RAD51D BRPF3-1 PCNA WRN PLAGL1 PERP PMS2 SOCS3 RICTOR BRD7 PTPN1 TIGAR RPA1 RPA2 CDK4 MLH1 HIPK1 CDK2 POU4F1 POU4F2 HIPK2 TTC5 RPA3 CCNG1 RAD1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 MRE11 SESN3 SESN2 KMT5A NBN BNIP3L USP7 IGFBP3 USP2 CDC25C MSH2 FANCD2 KAT6A MAPKAPK5 SMYD2-1 BLM MDM2-2 NDRG1 NPM1-2 SLC38A9 BCL2L14 ZNF420 MAP2K6 FANCI BRPF1 CNOT10 FANCC CNOT4 CNOT6 RGCC TP53I3 CNOT7 BCL6 CNOT11 RHEB CNOT1 CNOT2 JMY CNOT3 PIN1 MDM4 RAD9B CNOT8 CNOT9 RAD9A PRR5 DYRK2 PPP1R13B PIDD1 EXO1 CASP6 PPP1R13L MLST8 CASP2 TOPBP1 ZNF385A RFC5 RFC3 RFC4 APAF1 RFC2 RABGGTB RABGGTA RBL2 RBL1 BIRC5 TMEM219 PRKAA1 TRPC3 RNF34 AURKB TP53INP1 RBBP8 RFFL E2F7 E2F8 ARID3A PML MTOR RAD50 BAX HDAC10 FASLG EPC1 PRDM7;PRDM9 FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PRKCQ PRMT6 PBRM1 ACTL6B BDNF CDK5R1 GCK YEATS4 MAPK1 MAPK3 ARID2 CCNA2-1 CCNA1 KDM5B PRKAB2 HDAC8 SCO2 REST PRKAG2 MED15 MED26 MED25 KIT PPARD PRKCB G6PC1 SP1 PTEN RRM2B USP9X PRKAA2 BRIP1 APOE PCK1 COX7B COX7C COX8A SREBF1 COX8C SRC SRF COX5B COX5A COX6C COX6A1 COX6A2 COX6B2 COX6B1 HDAC4 UBE2I THRB VDR NR1H2 RORA NR3C1 ESR1 NR2C1 NR4A2 NR5A1 AR RXRA SUMO1 RARA CARM1 PGR PPARG PPARA TP53 GLS NAMPT GAMT CSNK2A2 CGA NR1D1 CSNK2B GPI COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 97%6799198 Complex I biogenesis TIMMDC1 NDUFS2 NDUFS1 NDUFAF6 NDUFC2;NDUFC2-KCTD14 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 NDUFAF1 NDUFS5-1 HSCB TMEM126B ACAD9 SFXN4 NDUFC1 NUBPL NDUFA13 NDUFA11 NDUFA12 NDUFA10 NDUFAB1 NDUFB9 NDUFB8 NDUFB7 ECSIT NDUFB6 FOXRED1 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 OXA1L HSPA9 TMEM186 NDUFV3 NDUFV2 TMEM126A-1 NDUFV1 NDUFA9 NDUFA8 NDUFA7 NDUFB10 DMAC2 NDUFA6 NDUFB11 NDUFA3 PYURF NDUFS8 NDUFS7 NDUFS6 NDUFS4 NDUFS3 LYRM2 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME%R-HSA-9931510.1 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes ARNTL CLOCK CRTC1 CIPC TFEB PER2 PER1 NPAS2 DBP NR1D1 BHLHE40 CRY2 CRY1 SIK1;SIK1B RBM4;RBM4B RORC CREBBP KMT2A RORA TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion TRMT10C PRORP TRNT1 HSD17B10 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 97%9769740 Coagulation pathway SDC4 SDC2 SDC3 GP1BA HSPG2 APP SDC1 SERPINE1 ANO6 ANO5 SMPD1 SERPINE2 GPC1 ITGB3 PROS1 F13A1 GPC3 SERPINA5 THBD GPC2 CD177 GPC5 FGB FGA GPC4 GP1BB F2R FGG GPC6 F2 F3 ITGA2B F5 F7 PROCR F8 ADAMTS13 VWF F9 SERPING1 SERPINC1 KNG1 SERPIND1 AGRN PF4;PF4V1-1 F10 F12 F11 GP5 GP9 PROC F13B KLKB1 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 97%166187 Mitochondrial Uncoupling SLC25A4 SLC25A14 UCP1 SLC25A27 PM20D1 UCP3 UCP2 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162599 Late Phase of HIV Life Cycle PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A POLR2A NUP42 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B POLR2I RAE1 RANBP2 RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 UBAP1 NUP35 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 XPO1 UBA52 NUP214 GTF2H1 GTF2H3 GTF2H4 RPS27A UBB;UBC CDK7 MNAT1 TBP PPIA GTF2H2C;GTF2H2C_2;GTF2H2 CCNK NUP107 NUP188 CCNT1 GTF2B RCC1 SUPT16H NUP210 POLR2E POLR2F GTF2F1 POLR2H GTF2F2 NUP93 CHMP4C CHMP4B POLR2L CHMP4A VPS28 NUP205 TSG101 NEDD4L AAAS GTF2E1 ERCC3 GTF2E2 NUP160 NUP85 TPR ERCC2 NUP88 SUPT4H1-1 NUP155 FURIN VTA1 NUP153 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 CHMP2A NMT2 TAF4B ELL ELOC-1 TAF7L NUP62 ELOA NELFB ELOB CCNH NELFCD NELFA NELFE NDC1 SEC13 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins EIF2AK2 PIAS4 TOPORS SUMO1 RELA PIAS3 SUMO3 IKBKE UBE2I IKBKG NFKB2 NFKBIA PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage HPRT1 ADAL PNP-1 APRT DGUOK GMPR AMPD1 AMPD2 AMPD3 GMPR2 DCK ADA ADK CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase CALM3;CALM1 ADCY1 ADCY8 PRKX PRKACB-1 PRKAR2B PRKAR1B PRKAR1A PRKAR2A PRKACA-1 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3906995 Diseases associated with O-glycosylation of proteins C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ADAMTS7 SBSPON MUC3A MUC5AC ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 MUC6 GALNT3 NOTCH1 MUC17 C1GALT1 MUC5B MUC20 MUC21 B4GAT1 LFNG DAG1 LARGE1 ADAMTS16 POMGNT1 ADAMTS18 NOTCH2 NOTCH3 NOTCH4 ADAMTS4 ADAMTS5 MUC13 THBS1 ADAMTS1 ADAMTS8 ADAMTS9 ADAMTS13 POMT2 SEMA5A SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%168273 Influenza Viral RNA Transcription and Replication RPS14 RPS17 NUP133 RPS16 RPS19 RPS18 NUP50 POM121;POM121C NUP54 RPS11 RPL10A RPS10 RPS13 RPS12 POLR2A NUP42 POLR2B POLR2C RPL27A POLR2D NUP43 POLR2G POLR2I RAE1 RANBP2 IPO5 GRSF1 DNAJC3-1 RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 NUP35 RPS21 RPS24 RPS23 RPL36AL-1 NUP37 RPL7A RPLP0 HSP90AA1 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 NUP214 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 PARP1 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 NUP107 NUP188 RPL15-1 NUP210 POLR2E POLR2F GTF2F1 RPL3L RPL5-1 POLR2H GTF2F2 NUP93 POLR2L NUP205 RPLP1-2 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 POLR2J;POLR2J2;POLR2J3 RPL23A NUP62 RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 NDC1 RPS15 SEC13 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 97%5693537 Resolution of D-Loop Structures ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 MUS81 C1orf112 EME1-1 BRCA2 RAD51AP1 DNA2 SLX4 EME2 FIGNL1 GEN1 XRCC2 XRCC3 PALB2 SPIDR BRIP1 SLX1A;SLX1B MRE11 NBN BARD1 RBBP8 RTEL1 SEM1 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 97%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 VIRAL STRATEGIES TO EVADE IFIT ACTION%REACTOME%R-HSA-9690722.1 Viral strategies to evade IFIT action CUL1 IFIT1 IFIT3 IFIT2 SKP1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) VPS37C VPS37D VPS37A VPS37B CHMP3 CHMP6 CHMP7 CHMP5 HGS VPS4B CHMP4C VPS4A CHMP4B CHMP4A VPS28 TSG101 STAM MVB12B MVB12A UBA52 VTA1 CHMP2B RPS27A CHMP2A UBAP1 UBB;UBC VPS36 SNF8 VPS25 STAM2 ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport STOM PDZD11 SGK1-1 ATP8A2 ATP8A1 ATP12A ANO8 BEST2 ANO9 BEST3 ANO6 SLC9C2 BEST1 ANO4 BEST4 ATP6V1E1 ATP6V1E2 ANO5 ATP6V1G1 ANO2 ATP6V1G2 ATP11C ATP11B ANO3 ATP1B2 ANO1 ATP11A ATP1B1 SLC9B1 SLC9B2 SCNN1G CLCA4-1 SCNN1D SCNN1B SCNN1A RAF1 ATP6V0D1 ATP6V0D2 ATP6V1A TTYH3 TTYH2 ANO10 WNK4 NALCN ASIC4 UBA52 ASIC5 WWP1 CLCA2 ATP6V0A2 CLCA1 ATP6V0A4 ASIC2 ATP6V1D ASIC3 ATP6V1C1 ATP6V1F ATP6V0A1 ASIC1 ATP6V1C2 ATP8B4 ATP8B3 ATP8B2 ATP8B1 RPS27A ATP4B ATP4A FXYD4 FXYD3 UBB;UBC WNK1 FXYD1 WNK3 FXYD6 CUTC RYR1 RYR2 TCIRG1 RYR3 UNC80 CLCNKA;CLCNKB ATP7B CLIC2 ATP6V0B TSC22D3 TRDN ASPH ATP6V1B2 ATP6V0C ATP6V1B1 STOML3 ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 ATP10A ATP1A1 ATP2C2 ATP2C1 CLCN3 CLCN2 CLCN1 BSND SGK3;C8orf44-SGK3 ATP6V1G3 ATP9B ATP9A ATP1B3-1 ATP13A1 FXYD2;FXYD6-FXYD2 TPCN2 TPCN1 CLCN7 CLCN6 CLCN5 CLCN4 ATP6V0E2;ATP6V0E1 OSTM1 FKBP1B ATP13A4 ATP13A5 ATP13A2 UNC79 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPC3 TRPA1 TRPC4 CAMK2B TRPC1 CAMK2D TRPV2 CAMK2A TRPV3 TRPV1 MCOLN1 TRPC4AP CAMK2G MCOLN2 TRPV6 TRPV4 TRPV5 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 ATP2B1 SRI ATP6V1H CALM3;CALM1 NEDD4L ATP6AP1 ATP7A TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) CGN F11R FKBP1A PARD3 TGFB1 PRKCZ RPS27A PARD6A RHOA SMURF1 TGFBR1-1 ARHGEF18 TGFBR2 UBB;UBC UBA52 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME DATABASE ID RELEASE 97%9662851 Anti-inflammatory response favouring Leishmania parasite infection GNG10 GNAS-1 GNG2 ADCY9 GNG5 GNG4 PRKAR1B PRKAR1A GNG8 YES1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 CD163 ADCY5 PLK2 GNG13 RHBDF2 PRKACB-1 MYH9 GNB2 PRKAR2A GNB1 GNB4 GNB3 ITPR1 ADAM17 ITPR2 GNB5 ITPR3 CD3G CYSLTR1 CYSLTR2 GNAT3 SYK FGR HCK ADORA2B GNAI1 GNAZ PLCG1 GNAI3 GNAI2 FCGR3A;FCGR3B FYN FCGR1A PRKACA-1 PLCG2 GGT1 CALM3;CALM1 DPEP2 DPEP1 LYN IL10 GNGT1 GGT5 FURIN PRKAR2B AHCYL1 IL6 PRKX MAPK14 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function OPN1SW SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 97%5654741 Signaling by FGFR3 FGF20 FRS2 GAB1 SOS1 PPP2R1A FGF23 PIK3CA PTPN11 FGF2 UBA52 GALNT3 CBL PPP2CB;PPP2CA RPS27A UBB;UBC PLCG1 MAPK1 HRAS PIK3R1 BRAF MAPK3 FGF1 MKNK1 FRS3 FGF4 SPRY2 FGF16 NRAS FGF9 FGF18 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 97%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 APP NFKB2 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK TLR7 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 TICAM1 TLR9 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 NFKBIA RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 97%5619113 Defective SLC3A1 causes cystinuria (CSNU) SLC7A9 SLC3A1 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190370 FGFR1b ligand binding and activation FGF22 FGF3 TGFBR3 FGF10 GIPC1 FGF1 FGF2 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism DGAT2 FABP3 FABP5 DGAT1 PPP1CA FABP6 PNPLA4 FABP7 PNPLA5 MGLL GPD2 PPP1CC FABP12 GPAT2 CAV1 PLIN1 GK2 PRKACB-1 MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP4 GPAM PLIN3 AGMO LPIN1 LPIN2 LPIN3 GK FABP9 FABP1 PPP1CB LIPE FABP2 PRKACA-1 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 SLC38A1 GLUL ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112122 ALKBH2 mediated reversal of alkylation damage ALKBH2 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 97%171286 Synthesis and processing of ENV and VPU FURIN MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein GSK3A GSK3B PARP9 SUMO1 UBE2I PARP8 PARP16 PARP6 PARP14 PARP4 PARP10 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 97%74182 Ketone body metabolism BDH2 BDH1 HMGCS2 HMGCLL1 OXCT1-1 HMGCL AACS ACSS3 ACAT1 RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-HSA-5626467.3 RHO GTPases activate IQGAPs IQGAP1 MEN1 CLIP1 CALM3;CALM1 CDH1 CTNNB1 RAC1 IQGAP2 IQGAP3 CDC42 CTNNA1 SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste SCNN1G SCNN1D SCNN1B SCNN1A CALHM1 CALHM3 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 97%975577 N-Glycan antennae elongation ST3GAL4 MGAT4A-1 MGAT4C MGAT4B B4GALT2 ST8SIA6 B4GALT3 B4GALT1 ST8SIA2 B4GALT6 ST8SIA3 B4GALT4 B4GALT5 ST6GAL1 MGAT5 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 97%3301854 Nuclear Pore Complex (NPC) Disassembly CDK1 NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 NEK9 NEK6 AAAS NEK7 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 CCNB2 CCNB1 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A FOXO1-1 AKT2 AKT3 AKT1 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry HSPG2 GPC6 FURIN AGRN CTSV;CTSL VCP-1 SDC1 TMPRSS2 NRP1 GPC1 ACE2 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 GPC4 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 97%5579026 Defective CYP11A1 causes AICSR FDXR FDX1 CYP11A1 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling AREG TGFA CDKN1B BCL2 AKT2 AKT3 SRF FOXO3 CCND1 ELK1 EREG BTC EGF EGFR MAPK1 MAPK3 FOS HBEGF PTK2 UHMK1 XPO1 EPGN AKT1 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism SLC35D2 EXT1 IDS EXT2 CTSV;CTSL NDST2 NDST1 NAGLU NDST4 NDST3 GPC1 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 HPSE2 GPC4 HS3ST5 HSPG2 GPC6 HS3ST6 HS3ST4 HPSE HS3ST1 HS3ST2 HS6ST1 HS3ST3A1 HS6ST2 HS6ST3 EXTL2 AGRN SGSH SDC1 HS2ST1 HS3ST3B1 EXTL3 GLCE IDUA GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432722 Golgi Associated Vesicle Biogenesis DTNBP1 TPD52L1 PUM1 AP4B1 IGF2R NECAP1 GOLGB1 YIPF6 ACBD3 PIK3C2A ARF1 OCRL CPD PICALM AP4E1 ARRB1 CLINT1 AP1G1 FTH1 AP1S2 DNM2 VAMP2 AP1S1 AP1S3 SH3D19 SH3GL2 TPD52 AP1B1 VAMP7 AP3B1 AP3S2;AP3S1 VAMP8 GAK DNAJC6 NAPA RAB5C TFRC TGOLN2 BLOC1S4 BLOC1S6 SNX2 BLOC1S1 HSPA8 BLOC1S3 SNX9 AP1M2 SNX5 TXNDC5 AP1M1 TBC1D8B FTL-1 SNAPIN SORT1 HIP1R THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis TPO DUOX1 CGA DUOXA1 DUOXA2 TXNDC11 DUOX2 IYD DIO1 CAV1 DIO3 SLC5A5 TSHB DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 97%5688849 Defective CSF2RB causes SMDP5 SFTPB SFTPC CSF2RB CSF2RA SFTPD RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380320 Recruitment of NuMA to mitotic centrosomes CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 NUMA1 TUBG2 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling ARHGEF6 GNG10 PIK3R6 GNG2 PIK3R5 GNG5 AKT2 GNG4 AKT3 PAK1 GNG8 BTK RHOA GNG13 GNB2 GNB1 AKT1 GNB4 GNB3 GNGT1 GNB5 PDPK1 PLCB3 CDC42 PLCB1 PIK3CG PLCB2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%982772 Growth hormone receptor signaling SOCS3 STAT1 ADAM17 PTPN6 PTPN1 STAT5A STAT3 STAT5B IRS1 MAPK1 CISH IRS2 MAPK3 PRL PRLR GHR JAK2 LYN SOCS2 SOCS1 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2142789 Ubiquinol biosynthesis COQ3 COQ2 STARD7 PDSS2 HPDL PDSS1 COQ8A COQ9 COQ7 COQ6 COQ5 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%3858494 Beta-catenin independent WNT signaling GNG10 GNG2 GNG5 GNG4 GNG8 GNG13 GNB2 GNB1 GNAT2 PRKCG PSMD12 GNB4 WNT5B GNB3 RYK-1 PSMD11 ITPR1 WNT5A PSMD14 ITPR2 ROR1 PSMD13 GNB5 ROR2 ITPR3 LEF1 NLK PPP3R1 WNT1 PSMA7 FZD1 PSMD8 FZD3 FZD2 FZD5 PSMB6 FZD4 PSMB7 PSMD6 FZD7 FZD6 PSMB4 PSMD7 FZD8 NFATC1 PARD6A GNAO1 PSMB5 CLTB PSMB2 ARRB2 PSMB3 PSMD2 PPP3CA PSMD3 PPP3CB PRKG1 PSMB1 PSMD1 PRICKLE1 PDE6B PDE6A ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PRKG2 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 SCRIB PSMC1 CTNNB1 RAC1 TCF7 PFN1 RHOA VANGL2 TCF7L1 CLTC CLTA UBA52 AP2A1 AP2B1 AP2A2 PRKCA AP2S1 RAC3 RPS27A UBB;UBC MAP3K7 PRKCB DAAM1 WNT11 WNT4 SMURF2 SMURF1 CAMK2A TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B CALM3;CALM1 GNGT1 PLCB3 TCF7L2 PLCB1 PLCB2 DVL1 DVL2 DVL3 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 97%190873 Gap junction degradation GJA1 CLTB MYO6 DNM1 DNM2 DAB2 CLTCL1 CLTC CLTA RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8931987 RUNX1 regulates estrogen receptor mediated transcription RUNX1 GPAM AXIN1 KCTD6 ESR1 CBFB DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 97%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) TPST2 RUNX3 RUNX1 TBX21 TNF IFNG STAT4 CCL3L1;CCL3L3;CCL3;CCL18 NFATC1 IL12RB2 MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 97%9865114 Maple Syrup Urine Disease DLD BCKDHA PPM1K DBT BCKDHB NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717301.2 NVP-TAE684-resistant ALK mutants ALK P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 97%69563 p53-Dependent G1 DNA Damage Response MDM2-2 CCNA2-1 CCNA1 MDM4 PSMD12 CHEK2 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PHF20 PSMD6 ZNF385A PSMB4 PSMD7 PSMB5 PSMB2 TP53 PSMB3 PSMD2 PSMD3 PCBP4 PSMB1 PSMD1 ADRM1 COP1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 ATM PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 UBA52 CDK2 RPS27A CDKN2A UBB;UBC CCNE2 CCNE1 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 97%5620924 Intraflagellar transport DYNLT2B IFT57 KIF17 DYNC2H1 HSPB11 IFT140 DYNC2LI1 IFT74 DYNLT5 WDR35 DYNLT2 IFT80 IFT20 IFT88 IFT22 IFT43 IFT81 TTC30A;TTC30B TRIP11 IFT27 DYNLRB2 DYNLRB1 IFT46 CLUAP1 KIF3A TTC21B TNPO1 WDR19 IFT122 KIFAP3 IFT172 DYNC2I2 DYNC2I1 KIF3B TTC26 TRAF3IP1 IFT52 KIF3C SIGNALING BY AMER1 MUTANTS%REACTOME DATABASE ID RELEASE 97%4839748 Signaling by AMER1 mutants PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 97%400206 Regulation of lipid metabolism by PPARalpha NR1H4 G0S2 MED13L NR1H3 FAM120B AGT MED1 ACSL1 MED4 MED6 AHR MED7 PEX11A CCNC-1 PPARGC1A PPARGC1B CREBBP RGL1 SREBF2 CLOCK ABCB4 ACADM ESRRA MED16 MED17 NFYA-1 MED12 MED14 MED13 MED10 CD36 RXRB NCOA1 NCOA2 MED19 NCOA6 MED15 NCOA3 ABCA1 MED18 HMGCS2 MED11 MED27 MED23 APOA2 NCOR2 APOA1 APOA5 NCOR1 MED26 MED24 TXNRD1 MED29 MED22 MED20 MED25 PLIN2 ANGPTL4 MED21 GPS2 MED31-1 CHD9 EP300 CPT2 CPT1A SLC27A1 TBL1XR1 TIAM2 FABP1 FADS1 MED30 HELZ2 CDK8 HMGCS1-1 NRF1 NPAS2 SULT2A1-4 TGS1 NR1H2 RORA GLIPR1 SP1 SIN3A ANKRD1 RXRA CYP7A1 ALAS1 CARM1 PPARG PPARA FHL2 ME1 MED8 NFYB MED9 ARNT NFYC GRHL1 SMARCD3 HDAC3 ARNTL TNFRSF21 ARNT2 FDFT1 NR1D1 CDK19 CYP1A1 MTF1 AHRR TRIB3 MED28-1 THRAP3 ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants ALK ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets PPP2R1A MAPK7 PPP2CB;PPP2CA PPP2R5D ELK1 RPS6KA3 PPP2R1B RPS6KA5 DUSP4 RPS6KA2 DUSP3 RPS6KA1 VRK3 MEF2A DUSP6 MAPK14 DUSP7 MAPK1 MEF2C MAPK11 MAPK3 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME%R-HSA-5579000.3 Defective CYP1B1 causes Glaucoma CYP1B1 LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.3 LGI-ADAM interactions DLG4 STX1A LGI1 LGI4 LGI3 LGI2 ADAM11 ADAM22 CACNG8 ADAM23 CACNG2 CACNG3 CACNG4 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 97%3323169 Defects in biotin (Btn) metabolism HLCS MCCC1 PCCB ACACA MCCC2 BTD PC PCCA ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation HECTD1 HECTD2 ASB10 HECTD3 TRIM41 RNF25 FBXL19 FBXL18 FBXL15 TRIM74;TRIM73;TRIM50 FBXL16 CDC20 FBXL13 FBXL14 FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 TRIM36 ASB7 TRIM37 ASB4 ASB5 ASB2 TRIM32 ASB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 MIB2 BTRC PSMC3 PSMA1 RBCK1 PSMC4 PSMC1 SKP1 FBXW11 UBA52 CUL1 RPS27A UBB;UBC UBE2V1 RBX1 UBE2N ITCH LRRC41 CUL3 VHL KBTBD7 FBXO32 NEDD4L TRIM63 FBXO4 FBXO6 FBXW4 FBXW10;CDRT1 FBXW5 FBXW7 FBXW9 ELOC-1 FBXW2 ELOB STUB1 SOCS1 FBXL3 FBXL5 RNF111 RBBP6 UBE2D3-1 UBA7 UBE2L6 HERC5 LRR1 WWP1 CCNF KEAP1 CBLB SOCS3 DCAF1 SH3RF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 TRIM21 FBXO7 FBXO9 HERC6 TRAIP-1 WSB1 FBXO2 RNF123 RNF126 HECW2 ANAPC13 UBE2J2 UBE2J1 RNF217 ATG7 TRIM11-1 HACE1 SIAH2 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 FBXL7 DZIP3 RNF220 DET1 LRSAM1 TRIM9 ARIH2 RNF144B GAN PRKN RNF130 GPR75-ASB3;ASB3-1 HUWE1 KLHL2 KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 UBR2-2 LTN1 RNF19B UBE3A UBE3B UBE2Z FBXO21 FBXO22 NPEPPS RNF19A MYLIP FBXW12 AREL1 KCTD6 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 SMURF2 UBE2E2 SMURF1 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 RNF41 KLHL42 UBE2V2 CUL7 RNF34 CUL5 UBA6 UBA5 CUL2 UBR4 KLHL11 KLHL13 UBR1 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 UBE2F UBE2H UBE2B KLHL25 ZBTB16 GLMN KLHL21 KLHL22 BTBD6 FBXO30 KLHL20 FBXO31 CDC34 UBE2W UBOX5 UBE2U MKRN1 UBA3 RNF182 TPP2 UBE2O BLMH UBE2D3;UBE2D2 UBA1 UBE2K TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 UBE2D1 TRIM69 UNKL ANAPC10 DTX3L ANAPC11 PJA2 PJA1 FZR1 CDC23 TRAF7 CDC26 UBE2R2 CDC27 RNF138-1 THOP1 ANAPC7 RNF213-2 MGRN1 UBE2C ASB13 UBE2E1 ASB14 RNF6 ASB11 UBE2S RNF7 CDC16 ASB12 ANAPC4 ASB17 ANAPC5 RNF4 ANAPC1 RCHY1 ANAPC2 ASB18 FBXL22 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390651 Dopamine receptors DRD1 DRD2 DRD3 DRD4 DRD5 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 97%380615 Clearance of seratonin MAOA SLC6A4 ALDH2 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis GBA AP3M1 STAT3 CCT8 CCT7 CCT5 CCT4 NOP56 ARFGEF2 CCT6A DCAF7 CCT6B SKIV2L FBXL3 KIF13A FBXO4 FBXL5 LONP2 FBXO6 WRAP53 CCT3 FBXW4 CCT2 FBXW10;CDRT1 FBXW5 FBXW7 TP53 SPHK1 FBXW9 FBXW2 CCNE2 CCNE1 TCP1 XRN2 GAPDHS FKBP9 HDAC3 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%400042 Adrenaline,noradrenaline inhibits insulin secretion GNB3 GNGT1 GNB5 ADRA2C ADRA2A GNG10 GNG2 GNG5 GNG4 CACNA1D GNG8 CACNA1C GNAI1 GNAI2 ADCY6 GNG13 ADCY5 CACNB2 CACNB3 CACNA2D2 GNB2 GNB1 GNB4 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency GSS DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death BCL2L11 CDK5 CAPNS1 CAPNS2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CAPN2 CAPN1 CAST H2BC21 GOLGA2 RIPK3 CDC25A DNMT3B CDC25B APP PRIM2 PRIM1 MLKL H2AC20 POLA1 EED POLA2 H2AB2;H2AB3;H2AB1 DNMT3A GSDME H2AZ2;H2AZ1 EZH2 TP53 PRDX2 PRDX1 YWHAE JUN TRADD RBBP4 FASLG TRAF2 H2AJ CASP8 FOXO3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RIPK1 FADD RBBP7 LMNB1 H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 H2BC5 H2BC1 CDK5R1 SOD2 C1QBP CDKN2A H2AC4 DNMT1 H2AC14 CDC25C FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%8978868 Fatty acid metabolism PTGIS PLA2G4A PHYH-4 HADHA ACSL1 PON3 PTGES3-1 HPGD PON2 SCP2 PON1 LTC4S PRKAB2 CROT TECR ALOX5AP HACD1 CYP4F22 ACADL HSD17B3 HSD17B4 ACADM ACADS LTA4H HACD3 TECRL HSD17B8 HACD2 PRXL2B HACD4 CYP2J2-1 PRKAG2 ELOVL5 GPX1 ACAA1-1 CYP8B1 GPX4 NUDT7 NDUFAB1 ACAA2 FAAH2 CBR1-1 EHHADH-1 GGT1 PCCA ELOVL1 PCCB DPEP2 ELOVL4 DPEP1 ACACA ELOVL2 ALOXE3 ACOT11 ELOVL3 ACOT12 ACOT13 ELOVL6 ELOVL7 PTGR2 FAAH ACSBG1 ACSM3 ACSBG2 GGT5 PPARD MAPKAPK2 PTGDS PTGS1 ACSL6 ACSL5 CPT2 CPT1A CRAT SLC27A1 CPT1B FASN FADS2 CYP2U1 NUDT19 PTGES ACSL4 ACSL3 FADS1 SLC22A5 ACLY SLC27A3 SLC27A2 ACOXL MORC2 PECR HPGDS ACOX2 ACOX3 ALOX15B ACBD5-1 THEM5 TBXAS1 THEM4 HACL1 RXRA CYP1B1 MMUT ABCD1 ACOT9 ECHS1 ACOT8 CBR4 MECR ACOT2;ACOT1 ACOT7 PTGES2 SLC25A17 ALOX12B ACOT4 OLAH HADH PRKAA2 SCD5 AWAT1 ALOX15 MCAT ALOX12 HSD17B12 MID1IP1 CYP2C9;CYP2C19 CYP4B1 EPHX2 PPT1 CYP1A1 ALOX5 CYP1A2 PPT2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ECI1 ACBD7 ACBD6 SCD ACBD4 SLC25A20 THRSP ACSF3 MCEE ACSF2 AMACR MMAA ACADVL HADHB-1 PTGS2-2 ACAD11 PCTP ACAD10 PTGR1-1 DECR2 DECR1 ABCC1 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%399719 Trafficking of AMPA receptors CAMK2G MDM2-2 GRIA2 MYO6 CACNG8 CACNG2 CACNG3 CACNG4 AP2A1 PRKCG DLG4 PRKCA GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 CAMK2B CAMK2D CAMK2A PRKCB AKAP5 ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 97%417973 Adenosine P1 receptors ADORA2B ADORA2A ADORA3 ADORA1 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants PDGFRA SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 97%5654738 Signaling by FGFR2 FGF20 NCBP1 SOS1 FGF23 FGF2 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I NCBP2-1 PLCG1 HRAS PIK3R1 TIAL1 FGF6 PTBP1 MKNK1 RBFOX2 SPRY2 ESRP2 HNRNPH1 NRAS ESRP1 FRS2 HNRNPA1-1 GAB1 TIA1 PPP2R1A PIK3CA HNRNPM PTPN11 POLR2E FGF7 FGFBP1 POLR2F FGFBP3 GTF2F1 POLR2H GTF2F2 FGF22 FGF3 FGF10 POLR2L UBA52 CBL PPP2CB;PPP2CA HNRNPF POLR2J;POLR2J2;POLR2J3 RPS27A UBB;UBC MAPK1 BRAF MAPK3 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 97%9766229 Degradation of CDH1 MDM2-2 CTNNA1 CDH1 JUP PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 SRC PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 BANP ADRM1 CTSS PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CTNND1 PSMC6 MTBP PSMA4 RACK1 CBLL1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 CTSB CTSV;CTSL UBA52 DNM2 RPS27A UBB;UBC FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029480 Fcgamma receptor (FCGR) dependent phagocytosis ABL1 ARPC4 ARPC5 WAS ARPC2 LIMK1 ARPC3 PAK1 YES1 NF2 ACTB-1 NCKAP1L MYO9B NCK1 MYH9 ACTR2 ARPC1B ARPC1A ITPR1 HSP90AB1 ITPR2 WASL ITPR3 ACTG1 CD3G CDC42 SYK FGR HCK PIK3R2 PIK3CB PLCG1 PIK3R1 FCGR3A;FCGR3B FYN WASF2 FCGR1A WASF3 BAIAP2 PIK3CA NCKIPSD PRKCE PLPP5 PLPP4 PLCG2 RAC1 MYO10 HSP90AA1 BTK MYO5A MYO1C ABI2 ELMO1 ABI1 ELMO2 PLD4 CRK CFL1 DOCK1 PLD1 PLA2G6 LYN PTK2 PLD3 PLD2 PRKCD ACTR3-1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 AHCYL1 WIPF1 WIPF2 WIPF3 VAV1 VAV2 MAPK1 MAPK3 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 97%6809371 Formation of the cornified envelope DSP SPRR3 CSTA KLK5 PCSK6 EVPL CAPNS1 KLK8 PPL LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 JUP TGM1 CASP14 DSG1 LIPJ PKP4 SPRR1A;SPRR1B LIPN LIPM CAPN1 PRSS8 LIPK TGM5 ST14 PERP CDSN SPINK6 SPINK5 KLK13 KLK14 DSG2 FURIN KAZN CELA2B;CELA2A LCE6A PKP2 PKP1 LORICRIN DSG3 PKP3 SPINK9 DSG4 DSC1 IVL DSC2 DSC3 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-HSA-111471.6 Apoptotic factor-mediated response UACA CASP3 BAX C1QBP GSDME APIP CYCS-1 CDKN2A APAF1 AVEN GSDMD DIABLO-1 CASP9 MAPK1 CASP7 BAK1 MAPK3 XIAP NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 97%392154 Nitric oxide stimulates guanylate cyclase PDE11A PRKG2 ITPR1 PDE10A KCNMB1 KCNMB2 KCNMA1 KCNMB3 KCNMB4 NOS1 PDE9A NOS3 NOS2 GUCY1A2 PDE5A GUCY1A1 GUCY1B1 PDE1B PDE1A PDE2A IRAG1 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 97%9670095 Inhibition of DNA recombination at telomere ACD TINF2 ATRX H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 POLR2E TERF2IP TERF1-1 POLR2F POLR2H POLR2L POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C H2BC15;H2BC3;H2BC11;H2BC12 POLR2D H2BC5 H2BC21 POLR2G H2BC1 POLR2I DAXX H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 POLR2J;POLR2J2;POLR2J3 H2AC4 H2AC14 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%8851907 MET activates PI3K AKT signaling GAB1 PIK3CA MET PIK3R1 HGF DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function OPN1MW3;OPN1MW2;OPN1MW;OPN1LW MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69618 Mitotic Spindle Checkpoint NUP133 NDC80 BUB1 RANGAP1 CLASP2 BUB1B CDC20 PPP1CC BUB3 MAD2L1 SPDL1 NUP43 RANBP2 NSL1 RPS27 NUP37 MAPRE1-1 PPP2R1A KNL1 ZW10 DSN1 CKAP5 RCC2 ZWINT XPO1 AHCTF1 PAFAH1B1 DYNC1I2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E DYNC1H1 NDE1 PLK1 DYNC1LI1 DYNC1LI2 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 DYNC1I1 B9D2 SPC24 SPC25 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP KNTC1 CENPA BIRC5 CENPE CENPC SGO1 SGO2 AURKB CENPS-CORT;CORT;CENPS CENPT NUP107 CENPU CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPO NUP160 CENPP NUP85 CENPQ ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 CLIP1 MAD1L1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP SEC13 NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 97%418886 Netrin mediated repulsion signals UNC5A DCC UNC5B PTPN11 UNC5C UNC5D NTN1 SRC PEXOPHAGY%REACTOME DATABASE ID RELEASE 97%9664873 Pexophagy ATM MAP1LC3B2;MAP1LC3B-1 UBB;UBC NBR1 PEX5 USP30 SQSTM1 EPAS1 RPS27A UBA52 TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8963684 Tyrosine catabolism TAT HPD GSTZ1 HGD FAH SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction MPP5 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 97%9608287 Defective MUTYH substrate binding SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702624.2 sorafenib-resistant FLT3 mutants FLT3 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 97%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 ZNF598 RPL27A ASCC2 RPL8 ASCC3 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 UBE2D3-1 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBE2D3;UBE2D2 UBA52 RPS2 UBE2D1 RPL18A RPL23A FAU RPL12-1 RPS27A UBB;UBC RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 97%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs FASTKD5 TBRG4 FASTKD2 REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity AKT2 AKT3 CSNK2A1;CSNK2A3 NEDD4 PSMD12 PSMD11 TRIM27 PSMD14 USP13 PSMD13 TNKS TNKS2 RNF146 PSMA7 FRK OTUD3 PSMD8 PTEN PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CSNK2A2 PSMC3 PSMA1 PSMC4 PSMC1 WWP2 CSNK2B MKRN1 AKT1 UBA52 RPS27A UBB;UBC PREX2 STUB1 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs CALM3;CALM1 CAMK1 CAMKK1 RAC1 GIT1 CAMKK2 LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 97%9658195 Leishmania infection ARPC4 ARPC5 GNG10 GNG2 ARPC2 GNG5 ARPC3 GNG4 NOXA1 GNG8 YES1 CD163 PLK2 GNG13 NCK1 RHBDF2 MYH9 GNB2 ACTR2 GNB1 GNB4 GNB3 ITPR1 WNT5A ITPR2 GNB5 ITPR3 WASL MEFV NFKB2 PYCARD P2RX7 PSTPIP1 FZD7 CASP1 TXNIP SUGT1 GNAI1 PLCG1 GNAI2 WASF2 WASF3 BAIAP2 PRKACA-1 JUN RAC1 MYO10 BTK MYO5A MYO1C GGT1 DPEP2 DPEP1 ELMO1 ELMO2 CRK DOCK1 PTK2 GGT5 PRKAR2B CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 GSDMD VAV1 VAV2 MAPK14 MAPK8 ABL1 TXN GNAS-1 WAS NOXO1 ADCY9 PRKAR1B PRKAR1A ACTB-1 ADCY4 ADCY3 NLRP3 NCKAP1L ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MYO9B PRKACB-1 NOX1 PRKAR2A ARPC1B ARPC1A ADAM17 HSP90AB1 NT5E ACTG1 C3AR1 CD3G IL18 CYSLTR1 IL1A CYSLTR2 IL1B CDC42 GNAT3 P2RX4 SYK FGR HCK ADORA2B GNAZ GNAI3 CYBA FCGR3A;FCGR3B FYN FCGR1A C3-1 NCKIPSD CTSG HMOX1 PLCG2 ABI2 CALM3;CALM1 ABI1 LYN IL10 GNGT1 ACTR3-1 FURIN RELA AHCYL1 NFKB1 IL6 PRKX MAPK1 MAPK3 ENTPD1 DVL1 ENTPD5 DVL2 DVL3 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism GLB1 ST6GALNAC5 ST6GALNAC6 ST3GAL5 ST8SIA5 CTSA ST6GAL1 ST3GAL4 ST6GALNAC2 ST3GAL1 ST3GAL2 ST3GAL3 SLC35A1 ST8SIA6 ST8SIA2 ST8SIA3 ST6GALNAC1 CMAS NPL NEU2 NEU3 NANP ST6GALNAC3 NEU4 ST6GALNAC4 ST8SIA4 SLC17A5 NEU1 NANS ST6GAL2 ST8SIA1 GNE ST3GAL6 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling CD274 HDAC1 STAT3 PRDM1 IL2RG HIF1A DNMT1 HDAC2 EP300 SIN3A HDAC3 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MCCC1 MCCC2 MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) EIF4A3 CNOT10 CNOT4 KDM5A CNOT6 KDM5B CNOT7 KDM6B CNOT11 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CNOT1 CNOT2 CREBBP CNOT3 H2BC21 CNOT8 CNOT9 KDM6A H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 SRPK1 TP53 EIF4A2 BTG4 EIF4A1 TUT7 TUT4 DUXB UHRF1 DIS3L2 STPG4 DICER1 METTL23 DPPA4 DPPA3 DPPA2 ZFP36L2 AGO2 LEUTX HIRA H2AJ DUX4;DUXA TEAD4 EIF4E H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 EIF4B PAIP1 NPM2 AICDA TET3 H1-8 TNKS1BP1 TPRX1;RAX2 ZSCAN4 PABPN1-1 CNOT6L H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 YAP1-1 EP300 H2AC4 PABPC1;PABPC3 EIF4G1 H2AC14 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission KCNJ2 KCNJ12;KCNJ18 KCNJ3 GABRQ KCNJ4 GABRA2 GNG10 GABBR2 GABRA1 GNG2 KCNJ5 GNG5 GABBR1 GNG4 KCNJ6 KCNJ10 GNG8 GABRA6 GABRA5 KCNJ9 GABRA4 GABRA3 KCNJ15 RASGRF2 KCNJ16 GRIN1 GLRB APBA1 PRKAB2 GNG13 GNB2 GNB1 PRKCG GNB4 GNB3 GNB5 PRKAB1 SRC GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 GNAI1 GNAI2 PRKAG2 PRKACA-1 KIF17 PRKAG1 RAC1 PRKAG3 NRG1 CACNG8 CACNG2 CACNG3 CACNG4 AP2A1 PRKCA PRKAR2B GIT1 RPS6KA3 RPS6KA2 KPNA2 RPS6KA1 PRKCB MDM2-2 ADCY9 PRKAR1B PRKAR1A GRIN2A ADCY4 ADCY3 MYO6 GRIN2B ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A CAMK4 PDPK1 CAMK1 CAMKK1 CAMKK2 GNAT3 HRAS GNAI3 PRKAA1 CAMK2B CAMK2D CAMK2A NRAS AKAP5 CAMK2G PRKAA2 GRIA2 CALM3;CALM1 RPS6KA6 CHRNB2 ACTN2 CHRNA2-1 CASK CHRNA1 CHRNB4 CHRNA9 CHRNA3 LIN7A CHRNB3 LIN7C CHRNA5 GRIN2C CHRNA4 GRIN2D CHRNA6 GRIN3B GRIN3A GNAL DLG2 DLG3 DLG4 GNGT1 NBEA GABRB3 GABRB2 GABRB1 GRIK5 RASGRF1 GRIK3 GRIK4 GRIK1 GRIK2 NRGN PLCB3 GABRR3 GABRR2 GABRR1 GABRG3;GABRG2 PLCB1 NPTN PLCB2 NEFL HTR3A HTR3B LRRC7 LIN7B CHRNA7;CHRFAM7A PRKX MAPK1 PPM1E PPM1F MAPK3 NCALD GLRA1 CHRND GLRA2 GLRA3 CHRNG CHRNE REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development HES1 SNW1 MAMLD1 AKT2 AKT3 KAT2B KAT2A HNF4G FOXO1-1 INS;INS-IGF2 FGF10 ONECUT1 NEUROD1 NKX6-1 NKX2-2 PDX1 CREBBP PAX6 HNF1A MAFA AKT1 RFX6 IAPP NOTCH1 INSM1 PTF1A FOXA3 HNF1B NEUROG3 GCK FOXA2 RBPJ MAML2 EP300 MAML1 SLC2A2 MAML3 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 H2BC5 H2BC21 H2BC1 DNMT3B PRIM2 PRIM1 H2AC20 POLA1 EED POLA2 H2AB2;H2AB3;H2AB1 DNMT3A GSDME H2AZ2;H2AZ1 EZH2 H2AC4 DNMT1 H2AC14 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium CCT8 CCT5 CCT4 HDAC6 ARF4-1 CYS1 LZTFL1 UNC119B ARL6 ARL3 FBF1 MCHR1 TTBK2 NPHP1 NPHP3 MARK4 RAB11FIP3 ARL13B BBS2 BBS1 RAB3IP BBIP1 AHI1 CEP83 YWHAE CEP89 CEP57 C2CD3 CETN2 CEP164 PKD2 CCP110 PKD1 DYNC2I2 AKAP9-1 TCTN3 DYNC2I1 TCTN2 TTC26 MAPRE1-1 TCTN1 TRAF3IP1 PRKACA-1 BBS9 ACTR1A CNGA2 DYNLT2B KIF17 TUBA1A BBS7 PPP2R1A HSPB11 CNGA4 DYNC2LI1 CNTRL BBS5 CEP250 CC2D2A IFT74 NEK2 BBS4 DYNLT5 IQCB1 DYNLT2 IFT80 CEP290 MKKS IFT20 YWHAG EXOC8 IFT22 RAB8A EXOC7 KIF24 IFT43 CDK5RAP2 IFT81 SSTR3 TTC30A;TTC30B HSP90AA1 BBS10 BBS12 TRIP11 CEP135 IFT27 RP2 DYNLRB2 TMEM216 DYNLRB1 EXOC4 EXOC3 IFT46 HAUS4 EXOC6 CLUAP1 HAUS3 EXOC5 CSNK1D EXOC2 HAUS6 CNGB1 HAUS5 EXOC1 TUBG1 ASAP1 CKAP5 TMEM67 HAUS2 PDE6D TUBA4A RHO HAUS1 SEPTIN2 CEP63 GBF1 SCLT1 RAB11A TNPO1 PAFAH1B1 ATAT1 DYNC1I2 TTC8 DCTN2 CEP162 SSNA1 B9D1 DCTN3 HAUS8 PRKAR2B KIFAP3 HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 IFT172 TUBB4B CEP97 NEDD1 KIF3B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ KIF3C IFT52 ALMS1 CDK1 IFT57 DYNC2H1 TPTEP2-CSNK1E;CSNK1E IFT140 CEP41 RPGRIP1L CEP43 WDR35 IFT88 SMO INPP5E KIF3A TTC21B B9D2 WDR19 IFT122 MKS1 CCT3 CCT2 TCP1 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes ATF4 MAFK NFE2L2 CREBBP EP300 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9025046 NTF3 activates NTRK2 (TRKB) signaling NTF3 NTRK2 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME DATABASE ID RELEASE 97%9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide RPL10A RPL27A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 RPL10;RPL10L-1 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RPL36AL-1 ADRM1 RPL7A PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 RPLP0 PSMC1 RPLP2 RPL36-1 RPL35A UBA52 ANKZF1 KLHDC10 NPLOC4 TCF25 UFD1 NEMF RPL18A RPL12-1 VCP-1 RPS27A UBB;UBC RBX1 RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 LTN1 RPL9 RPL6 RPL7 RPL35 RPL38 RPL39 RPL21 RPL23 RPL22 RPL24 CUL2 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 UBE2D3;UBE2D2 UBE2D1 RPL23A ELOC-1 RPL11 RPL14 RCHY1 ELOB RPL13 RPL18 RPL17 RPL19 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism MTR-1 LDLRAP1 MMADHC MTRR MMAA ABCD4 MMAB MMUT CTRB1;CTRB2 CUBN PRSS3;PRSS2;PRSS1 TCN2 CD320 CBLIF TCN1 LRP2 LMBRD1 MMACHC AMN ABCC1 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 97%9006936 Signaling by TGFB family members WWTR1 PPP1CC CCNC-1 SMAD2;SMAD3 BMP2 TGIF2 E2F4-1 PARD6A MTMR4 ARRB2 SERPINE1 TFDP1 JUNB RNF111 TFDP2 PPP1CB SNW1 PPP1CA UBE2D3-1 NCOR2 TCF12 NCOR1 RHOA CDKN2B XPO1 UBA52 CBL AMHR2 CER1 EP300 FST FOXH1 RPS27A ZFYVE16 MEN1 PSEN2 LTBP4 LTBP2 UBB;UBC LTBP3 LTBP1 APH1A APH1B TGFB2 TGFB3 GDF2 SKIL SMAD9 INHBB INHBA SMAD5 DRAP1 BAMBI TGIF1-1 MYF6 TCF4 BMPR1B MYF5 BMPR1A ITGB1 ACVRL1 BMP10 BMPR2 ITGB5 CHRDL1 ITGB8 CDK8 PMEPA1 ITGAV PRKCZ ITGB6 FGF2 AMH PSENEN MYOG HELLS NOG UCHL5 KLF16 COL1A2 GREM2 MYOD1 STRAP PPP1R15A USP15 ACVR1B FSTL1 FSTL3 ACVR1C SP1 ACVR2B PARP1 ACVR2A INHA RXRA ATP1B4 CGN RARA F11R PSEN1 FKBP1A PARD3 SKI SMAD1 ITGA8 NCSTN SMAD4 SMURF2 SMURF1 SMAD6 SMAD7 RBL1 YBX1 MYC MYCN HDAC1 TNRC6C CCNK MOV10 TIMP2 TNRC6A-1 AGO4 USP9X CCNT1 AGO2 TIMP1 AGO3;AGO1 TNRC6B TGFB1 TGFBR3 GIPC1 ITGB3 MMP14 NEDD4L MMP16 ARRB1 UBE2D1 FURIN PPM1A CDK9 CCNT2-1 E2F5 TGFBR1-1 ARHGEF18 TGFBR2 MAPK1 MAPK3 STUB1 TRIM33 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins NUDT16 ADPRM NUDT15 NUDT5 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%3296197 Hydroxycarboxylic acid-binding receptors HCAR1 HCAR2;HCAR3 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation HSPD1 NPM1-2 TFAP2A MYBL2 NOP2 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME%R-HSA-9943965.1 CHD3, CHD4, CHD5 subfamily FBP1 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I CHD3 G6PC1 H2BC21 PWWP2B CHD5 IKZF1 IKZF2 SUMO1 IKZF3 H2AC20 PHF6 MBD3L1 H2AB2;H2AB3;H2AB1 ZMYND8-1 PWWP2A H2AZ2;H2AZ1 CBX3-1 ADNP2 ZNF687 TCF19 ADNP ZNF592 ZNF827 CBX1 NR2F2 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 CDK2AP2 CDK2AP1 ZNF532 HDAC2 NR2C2 HDAC1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 MBD2 H2BC1 GATAD2B GATAD2A H2AC4 PCK1 H2AC14 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP2C9;CYP2C19 CYP1A1 CYP1B1 CYP1A2 CYP2U1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME%R-HSA-5619047.4 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression TGFA MED1 GTF2A1 PTGES3-1 GTF2A2 YY1 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C CREBBP ATF2 POLR2D POLR2G KDM4B KAT5 POLR2I H2AC20 GPAM H2AB2;H2AB3;H2AB1 POU2F1 NCOA1 NCOA2 PRMT1 NCOA3 JUN KAT2B H2AJ HSP90AA1 NR5A2 TLE3 FOS H2BC5 MYB H2BC1 KDM1A AXIN1 EP300 KPNA2 H2AC4 BCL2 DDX5 GATA3 CITED1 ESR1 SP1 H2BC21 HSP90AB1 TBP PGR CARM1 KCTD6 H2AZ2;H2AZ1 FOXA1 SMC3 FKBP4 MYC RAD21 JUND GREB1 STAG1 CXCL12 STAG2 HDAC1 SMC1A TFF1 KANK1 TNRC6C MOV10 CXXC5 TFF3-1 TNRC6A-1 AGO4 NRIP1 CCNT1 AGO2 USF2 USF1 CTSD AGO3;AGO1 ZNF217 FOSB TNRC6B EBAG9 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 POLR2E CBFB POLR2F GTF2F1 POLR2H GTF2F2 RUNX1 POLR2L H2BC15;H2BC3;H2BC11;H2BC12 CDK9 POLR2J;POLR2J2;POLR2J3 H2AC14 SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 97%9753512 Signaling by RAS GTPase mutants KRAS HRAS NRAS BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB-1 HADHA ACADL TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 97%210993 Tie2 Signaling SOS1 PIK3CA PTPN11 ANGPT4 ANGPT2 GRB7 ANGPT1 DOK2 TEK GRB14-1 PIK3R2 SHC1-1 PIK3CB HRAS PIK3R1 NRAS M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME%R-HSA-9820841.1 M-decay: degradation of maternal mRNAs by maternally stored factors CNOT8 CNOT9 DICER1 EIF4A3 ZFP36L2 AGO2 EIF4E EIF4B PAIP1 CNOT10 CNOT4 CNOT6 TNKS1BP1 PABPC1;PABPC3 CNOT7 CNOT6L CNOT11 CNOT1 CNOT2 EIF4G1 EIF4A2 BTG4 CNOT3 EIF4A1 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex CDK1 CHEK2 CHEK1 SFN YWHAZ YWHAQ CCNB1 YWHAH YWHAG CCNA2-1 CCNA1 YWHAE YWHAB WEE1 CDC25C GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) RBX1 COPS4 COPS2 CDK7 ACTB-1 MNAT1 YY1 PIAS3 UBE2I POLD1 UBE2N PARP1 PIAS1 SUMO1 SUMO3 SUMO2 RFC5 RFC3 RFC4 RFC2 GPS1 RNF111 CETN2 UBE2V2 GTF2H2C;GTF2H2C_2;GTF2H2 ACTL6A LIG1 POLK POLE NFRKB RFC1 PARP2 ACTR5 USP45 DDB2 LIG3 RAD23A ERCC3 CHD1L PCNA MCRS1 ACTR8 UBA52 ERCC5;BIVM-ERCC5 RAD23B ERCC2 DDB1 GTF2H1 INO80C GTF2H3 INO80B GTF2H4 INO80E INO80D RPA1 XPA RPA2 COPS7B COPS7A XPC POLD3 TFPT POLD4 POLD2 RPA3 RPS27A XRCC1 INO80 POLE4 CUL4A UBB;UBC COPS3 COPS6 COPS5 ERCC4 POLE2 ERCC1 POLE3 RUVBL1 COPS8 CCNH CUL4B LDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964038 LDL clearance SOAT1 AP2A2 SOAT2 NPC2 LDLRAP1 AP2S1 APOB CES3 LDLR PCSK9 CLTC LSR CLTA LIPA AP2A1 NCEH1 AP2B1 NPC1-1 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events CHRNB2 CHRNA7;CHRFAM7A CHRNA2-1 CHRNA1 CHRNB4 CHRNA9 CHRNA3 CHRNB3 CHRNA5 CHRND CHRNA4 CHRNA6 CHRNG CHRNE SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 97%74749 Signal attenuation SOS1 IRS1 INSR SHC1-1 INS;INS-IGF2 GRB10 MAPK1 IRS2 MAPK3 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-75108.6 Activation of BID and translocation to mitochondria GZMH;GZMB-1 BID CASP8 NMT1 REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling PIAS1 SOCS3 PTPN6 PTPN11 PTPN1 SUMO1 IFNGR1 IFNGR2 JAK1 IFNG JAK2 SOCS1 SPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9845614 Sphingolipid catabolism ALDH3B2;ALDH3B1 PLPP3 SGPL1 PLPP2 ACER2 ACER1 PLPP1 ACER3 SGPP2 SGPP1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 97%9010553 Regulation of expression of SLITs and ROBOs RPS14 NCBP1 RPS17 RPS16 RPS19 MSI1 RPS18 HOXA2 ISL1 COL4A5 RPS11 GSPT2 RPL10A GSPT1 RPS10 LHX3 LHX2 RPS13 LHX4 RPS12 LHX9 USP33 ROBO1 UPF2 ETF1 ZSWIM8 SLIT1 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 LDB1 PSMB6 RPL10;RPL10L-1 PSMB7 NCBP2-1 PSMD6 RPS25 RPS27 PSMB4 PSMD7 RPS29 PSMB5 RPS20 PSMB2 RPS21 PSMB3 PSMD2 RPS24 PSMD3 RPS23 PSMB1 PSMD1 RPL36AL-1 ADRM1 RPL7A PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 RPLP0 PSMC1 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A UBB;UBC RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RBX1 ROBO2 EIF4A3 CASC3 RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 SLIT2 RPL31 RPL34 RPL8 RBM8A RPL9 RPL6 RPL7 RPS4X MAGOH;MAGOHB RPL35 RPL38 RPS3A UPF3B DAG1 RNPS1 RPL39 RPL21 RPL23 RPL22 RPL24 CUL2 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 RPL23A ELOC-1 RPL11 RPL14 ELOB RPL13 RPL18 RPL17 RPL19 RPS15 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes LPL MED30 PDK4 ABL1 MED1 ACSL1 CDK8 MGLL MED4 CDK5 MED6 MED7 AGPAT2 PAXIP1 PEX11A CCNC-1 DPY30 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PAGR1 PPARGC1B CREBBP H2BC21 CIDEC WDR5 RXRA KDM6A GPAM H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 LPIN1 ASH2L MED16 PNPLA2 MED17 MED12 MED14 MED13 MED10 CD36 CEBPA NCOA1 NCOA2 ACSS3 NCOA6 ELOVL5 NCOA3 HDAC3 DGAT2 MED27 SIRT1 MED23 NCOR2 RBBP5 H2AJ NR5A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 MED24 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 AJUBA SCD H2BC1 THRSP FABP4 MED31-1 EP300 PHLDA1 H2AC4 ADIPOQ TBL1XR1 RB1 KMT2D KMT2C LIPE H2AC14 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants KIT ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4EBP1 EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F RPS4X EIF3D EIF3A EIF3B RPS3A RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 EIF4A2 EIF4A1 EIF4E EIF2S2 EIF4B EIF2S3;EIF2S3B EIF2S1 RPS27L RPS15A RPS3 RPS2 FAU RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RPS15 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME%R-HSA-9630221.2 Defective NTHL1 substrate processing NTHL1 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events PLA2G4A CAMK2G GNA14 GNA15 ADCY9 GNA11 PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 GNAQ PRKAR2A PRKCG ITPR1 ITPR2 PRKCD NBEA PRKCA ITPR3 CAMK4 PDE1C PRKAR2B CAMKK1 GRK2 CAMKK2 PLCB3 PLCB4 PLCB1 AHCYL1 PLCB2 KPNA2 PRKX MAPK1 CAMK2B CAMK2D PDE1B PDE1A CAMK2A PRKACA-1 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus IP6K1 IP6K2 IPMK IPPK SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane PIKFYVE MTM1 MTMR2 FIG4 INPP5F PI4K2B MTMR4 INPP4A PIK3C3 INPP4B MTMR10 MTMR12 PIK3C2A PI4K2A VAC14 PIK3R4 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME DATABASE ID RELEASE 97%9672391 Defective F8 cleavage by thrombin F2 F8 VWF GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1306955 GRB7 events in ERBB2 signaling ERBB2 NRG1 NRG2 GRB7 COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 97%1474290 Collagen formation ADAMTS2 ADAMTS3 P4HB COL4A5 COL16A1 COL12A1 COL1A1 COL1A2 ADAMTS14 COL23A1 COL17A1 COL13A1 COLGALT2 ITGB4 LOXL3 PLOD3 LOXL4 PLOD2 PLOD1 LOXL1 LOXL2 COL10A1 BMP1 COLGALT1 COL9A1 COL27A1 COL9A3 P3H2 COL9A2 COL18A1 P3H1 COL14A1 PCOLCE LAMC2 P3H3 COL2A1 CTSS LOX MMP20 COL4A2 COL4A1 COL4A4 COL6A2 PXDN COL4A3 COL6A1 COL8A2 COL4A6 COL21A1 COL8A1 COL6A3 ITGA6 COL6A6 COL6A5 CTSB PPIB CTSV;CTSL PLEC MMP7 CD151 COL25A1 PCOLCE2 COL11A1 COL11A2 MMP3 SERPINH1 COL28A1 MMP9 CRTAP COL24A1 COL22A1 COL3A1 P4HA1 COL5A1 MMP13 P4HA2 COL5A3 P4HA3 COL7A1 COL5A2 COL20A1 COL15A1 LAMA3 COL19A1 COL26A1 LAMB3 TLL2 TLL1 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME%R-HSA-5579007.3 Defective ACY1 causes encephalopathy ACY1;ABHD14A-ACY1 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%212676 Dopamine Neurotransmitter Release Cycle UNC13B RAB3A SYT1 SYN3 VAMP2 STX1A CPLX1 SYN2 SYN1 SNAP25 RIMS1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 TSPOAP1 APBA1 LIN7B CASK LIN7A LIN7C LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 CALM3;CALM1 CAMK4 PRKACA-1 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933937 Formation of the canonical BAF (cBAF) complex ACTL6A BCL7C SMARCA2 DPF1 BCL7B SMARCA4 DPF2 DPF3 SMARCC1 ARID1A ARID1B ACTB-1 SMARCE1 SMARCD1 SMARCB1 SS18 BCL7A SS18L1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 97%901032 ER Quality Control Compartment (ERQC) EDEM2 EDEM3 AMFR RPS27A SYVN1 DERL2 EDEM1-1 RNF5 UBB;UBC RNF103 MAN1B1 OS9 RNF139 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 SEL1L UBA52 PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 97%9754189 Primitive streak formation MIXL1 SMAD2;SMAD3 LEF1 BMP4 CTNNB1 TCF7 FOXH1 SMAD4 POU5F1;POU5F1B SOX2 EOMES TBXT TRIM33 NANOG;NANOGP8 GSC TBPL2 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 97%2206285 MPS VI - Maroteaux-Lamy syndrome ARSB PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%1257604 PI3K AKT Signaling FGF20 FGF23 INSR PIK3R3 PIK3R6 AKT2 PIK3R5 AKT3 CSNK2A1;CSNK2A3 BMI1 RING1 HDAC5 PSMD12 RNF2 PSMD11 PSMD14 HDAC7 PSMD13 REST CBX8 PSMA7 CBX6 PSMD8 PHC2 PHC1 PSMB6 PSMB7 CBX4 PSMD6 CBX2 PSMB4 PSMD7 PIP5K1A PIP5K1B PSMB5 PHC3 PSMB2 PIP5K1C PSMB3 PSMD2 EGF PSMD3 ERBB2 PSMB1 PSMD1 EGFR PDGFRA ADRM1 FGF6 PSMC2-1 PSMA2-1 PSMA5 XIAP HGF SEM1 PSMA6 GAB1 PSMC5 PPP2R1A PSMA3 MET PSMC6 PSMA4 AREG PSMC3 PSMA1 PSMC4 PSMC1 FGF7 FGF22 FGF3 FGF10 KIT NTRK3 AKT1 UBA52 TSC2 KDM1A RPS27A UBB;UBC CASP9 PREX2 IER3 FLT3LG PDGFB CD19 EGR1 BAD CD28 SNAI1 SNAI2 STRN RCOR1 GAB2 PHLPP2 PHLPP1 IL33 CD86 IRAK1 KLB CD80 ATN1 SALL4 MAF1 INS;INS-IGF2 PDGFRB FGF19 FGFR4 AKT1S1 IL1RL1 TRAT1 RPS6KB2 FLT3 PIK3AP1 GSK3A TRIM27 USP13 TNKS TNKS2 RNF146 FRK PIP4K2A PDPK1 OTUD3 PIP4K2B PTEN PIP4K2C TRAF6 FYN MYD88 PTPN11 IRAK4 WWP2 FOXO4 FOXO3 EPGN TRIB3 STUB1 TGFA FOXO1-1 IRS2 ATF2 SGK1-1 LCK RRAGA RRAGC RRAGB SRC RRAGD EZH2 MAPKAP1 JUN CDKN1A CDKN1B RAC1 CHUK RPTOR NRG1 NRG2 EREG BTC NRG3 NRG4 HBEGF MBD3 SUZ12 RICTOR NTF3 GATAD2B GATAD2A PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG LAMTOR2 LAMTOR1 LAMTOR4 PPP2R5E LAMTOR3 LAMTOR5 VAV1 USP7 MDM2-2 SLC38A9 FGF2 GSK3B MECOM NEDD4 RHEB CHD4 CHD3 ESR1 THEM4 PRR5 EED MLST8 PPARG PIK3CD PIK3CG TP53 IRS1 PIK3R2 ESR2 PIK3CB NR4A1 PIK3R1 NR2E1 HDAC2 HDAC3 FRS2 HDAC1 PIK3CA PML MTOR TNRC6C MOV10 MTA1 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 TNRC6B CSNK2B RBBP7 MTA2 MTA3 MKRN1 NTRK2 BDNF MAPK1 MAPK3 FGF1 FGF4 FGF16 FGF9 FGF18 REGULATED NECROSIS%REACTOME%R-HSA-5218859.6 Regulated Necrosis PDCD6IP GZMH;GZMB-1 CHMP3 PRKN CHMP6 CHMP7 OGT-1 SDCBP CASP5;CASP4 RIPK3 TP63 ITCH MLKL IRF1 IRF2 GSDME IL18 CASP1 IL1A IL1B TP53 ELANE XIAP FLOT2 CASP3 BAX TRADD FASLG TRAF2 PELI1 BIRC2 BIRC3 CASP8 HSP90AA1 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A HMGB1-1 FADD CHMP4C CHMP4B CHMP4A UBA52 FLOT1 CYCS-1 CHMP2B RPS27A CHMP2A UBB;UBC CDC37 GSDMD BAK1 STUB1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events ARHGEF7 SOS1 GNA13 ARHGEF5 ARHGEF6 GNG10 NGEF GNG2 GNG5 GNG4 GNG8 PLXNB1 ABR RASGRF2 GNG13 GNB2 GNB1 ADRA1D PLEKHG2 ADRA1B GNB4 ADRA1A GNB3 TBXA2R GNA12 ARHGEF33 GNB5 ARHGEF37 ARHGEF38 SOS2 ROCK2 ARHGEF40 FGD1 FGD2 ROCK1 FGD3 FGD4 ARHGEF26 PLEKHG5 MCF2 BTK ECT2 RHOA ARHGEF39 KALRN NET1 TIAM1 GNGT1 ARHGEF10L AKAP13 MCF2L ARHGEF11 ARHGEF10 ARHGEF12 VAV3 ARHGEF15 ARHGEF17 TRIO ARHGEF16 ARHGEF19 ARHGEF18 ITSN1 RHOC VAV1 VAV2 RHOB TIAM2 PREX1 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 DISEASE%REACTOME DATABASE ID RELEASE 97%1643685 Disease ABCG5 DPM1 DPM2 DPM3 PDZD3 MARK3 DNAJC10 ELAVL2 UPK1A GBP2;GBP3;GBP1 FXR1-1 ABCC6 TPMT ABCC9 RPL10A DLL4 S1PR1 PPP1CC NEURL1 KERA SLC26A2 RAB5A RPL36AL-1 PRKG2 APOA1 TTR BCKDK MTRR RPL18A CYP2U1 SLC22A5 SLC35D1 TXN CD320 GBE1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CYP7B1 NT5E ACOT2;ACOT1 COMT RPL15-1 IDH1 OPLAH HK1 CYP2R1 DBT LUM CHSY1-1 LRAT RBP4 RBP1 RPL10;RPL10L-1 ABCB4 IQGAP1 SLC5A5 ABCA1 ARF1 RPLP0 RPLP2 RPL36-1 DLD VAMP2 RPL22L1 RPL37A-1 EPM2A KPNB1 CYP19A1 ACAT1 SRD5A3 B3GALT6 PIK3CD PIK3CG SLC25A15 RPL13A-1 SLC25A4 PPM1K MMAA MMAB RPL23A AHCYL1 ENTPD1 ENTPD5 PPP1R3C STX1A MMADHC PIK3R3 PIK3R6 PIK3R5 CTSA RPL27A WASL PPP1CA GGT1 MAT1A DPEP2 DPEP1 CYP11A1 GGT5 GCLC GCLM BCKDHA BCKDHB LMBRD1 PNP-1 RPIA CYP24A1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 ENO1 RPL8 RPL9 RPL6 RPL7 FDXR CYP1B1 RPL35 RPL38 MMUT RPL39 CUBN RPL21 RPL23 RPL22 MED8 MED9 FDX1 RPL24 NHLRC1 RPL27 HPRT1 RPL26 RPL29 RPL28 PLCG2 CHST14 CDK19 RPL3L ADA RPLP1-2 IVD RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 FMO3 FMOD NAGLU GYG2 GYG1 ITPR1 ITPR2 ITPR3 CYP4F22 RPL7A SLC37A4 AMN UGT1A1;UGT1A6 KCNJ11 TXNRD1 RPL35A ASS1 IMPDH1 IMPDH2 MMACHC MTR-1 CYP27A1 ACY1;ABHD14A-ACY1 MAOA CYP27B1 SCAP ASL CBLIF GYS2 GYS1 AUH ALDOB NMRAL1 ABCD4 SLC2A1 SLC2A2 SGSH HIBCH ABCC2 ABCC8 DCXR B4GALT7 PTGES3-1 PRELP B3GAT3 POMC APP MEFV NFKB2 PYCARD P2RX7 PSTPIP1 CASP1 TXNIP SUGT1 SKP2 CARS1 RAP1B HGF GAB1 MET AREG NFE2L2 EEF1G EEF1A1 EEF2 FGF7 FGF22 FGF3 FGF10 WNT3A TSC2 KDM1A KIF5B KLC1 PHF21A RCOR1 HMG20B JAK2 RAD51B RAD51C DOCK2 HBD;HBB CDC42 GUCY2C NOS2 HGS ATP6V1H CORO1A RAB7A LMNB1 PAK2 IL10 MSN SOD2 HNRNPF HNRNPA2B1 SNRPA1 SLC1A1 SLC1A3 SLC3A1 SLC6A20 SLC6A19 SLC36A2 SLC6A14 SLC7A7 SLC7A9 DUSP6 DUSP7 CD163 PLK2 RHBDF2 MYH9 KAT5 DAXX HUS1 DNA2 RHNO1 MAPKAP1 PRDX2 PRDX1 ATRIP BARD1 RAD17 ATM ATR CDKN1A BRCA1 RPTOR RMI2 RMI1 TOP3A RAD51D WRN PMS2 RICTOR RPA1 RPA2 MLH1 RPA3 RAD1 MRE11 NBN CDC25C MSH2 BLM MDM2-2 NPM1-2 RAD9B RAD9A PRR5 EXO1 MLST8 TOPBP1 RFC5 RFC3 RFC4 RFC2 RBBP8 PML MTOR RAD50 TLR3 HDAC10 H2AC16;H2AC11 ARID4A BRMS1 H2BC18 KDM7A HDAC8 REST SLC35A2 SLC35A3 SLC33A1 SLC35C1 SLC25A5 SLC29A3 SLC27A4 SLC25A6 ROCK1 MUC13 RBMX KIT NTRK3 SLC9A6 SLC9A9 ADAMTS13 VWF CYFIP2 CYFIP1 NCKAP1 WASF1-1 WIPF1 WIPF2 WIPF3 BCR DYNC1LI1 DYNC1LI2 NCKAP1L HNRNPC NOX1 ARPC1B ARPC1A ABI2 TAOK1 ABI1 TPM4 TPM3 CLIP1 DVL1 DVL2 DVL3 ARPC4 ARPC5 ARPC2 ARPC3 NOXA1 MAP3K11 NCK1 ACTR2 LCK ROCK2 SRC CSK WASF2 WASF3 BAIAP2 BTK CFTR SPTBN1 STAM PTK2 C1QBP VAV3 RHOG VAV1 VAV2 WAS NOXO1 TRAK1 DYNC1I1 BCAP31 HDAC4 MYO9B UBE2I NR3C1 ESR1 SUMO1 ACTG1 ECHS1 PPIA CPS1 ARG1 TP53 OTC CYBA STAM2 CSNK2A2 NCKIPSD CSNK2B CPSF7 ACTR3-1 ZAP70 CSNK2A1;CSNK2A3 VIM HDAC11 IRF4 HDAC5 HDAC9 AGK HDAC6 HDAC7 STAT5A STAT5B EGF ERBB2 PLCG1 EGFR YWHAE GFPT1 AKAP9-1 PPP1CB PRKACA-1 PPP2R1A NEK2 MIB2 BTRC YWHAG SKP1 HSP90AA1 CDC73 LEO1 UBA52 DYNC1I2 CUL1 CCNB1 PRKAR2B RPS27A ELK1 UBB;UBC DYNC1H1 MAP2K4 MAPK9 MAPK8 MAP2K7 TUBB4A;TUBB;TUBB8B;TUBB8 CEP43 BCL2L11 BAD STAT3 BCL2L1 CAPNS1 CDH1 CAPNS2 BSG CAPN2 HEY1 HEY2 CAPN1 CAST ADAM10 HSPG2 BCAN ADAM17 PSEN1 ADAMTS16 NCSTN ADAMTS18 ADAMTS4 ADAMTS5 ADAMTS1 CTSG ADAMTS8 ADAMTS9 FOXO4 CTSV;CTSL FOXO3 MMP9 DCN ITGA4 FURIN ACAN KLKB1 RB1 CCNH H2AC14 TRIM28 TGFA MED1 YES1 MED4 MED6 MED7 FOXO1-1 CCNC-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP IHH CCND3 CCND2 SMAD2;SMAD3 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 ASH2L MED16 MED17 MED12 JUNB MED14 MED13 MED10 CD36 MED27 MED23 NCOR2 KAT2B H2AJ KAT2A NCOR1 MED24 TAL1 MED20 GPS2 SF3B1 MBD3 SUZ12 H2BC5 H2BC1 GTF2H1 GTF2H3 GTF2H4 GATAD2B ITGA2B GATAD2A MED31-1 ARID4B EP300 NRBP1 H2AC4 SAP30 TBL1XR1 KMT2D DNMT1 MED30 CDK6 ABL1 SUDS3 CDK8 CDK7 CDK5 ACTB-1 MNAT1 GSK3B RAD51 PSIP1 DPY30 CHD4 CHD3 SIN3A PARP1 H2BC21 GP1BA DNMT3B WDR5 CAMK4 TBP EED DNMT3A H2AZ2;H2AZ1 SMAD4 ESR2 NR4A1 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 CAMK2B CAMK2D HDAC2 CAMK2A HDAC3 THBS1 HDAC1 HES1 CAMK2G MTA1 RBBP4 RBBP5 SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L ITGB3 PROS1 H2BC15;H2BC3;H2BC11;H2BC12 ERCC3 FGB FGA GP1BB ERCC2 FGG F2 F5 F8 F9 SERPING1 CLU F10 F12 F11 GP5 GP9 PROC EIF2AK2 PRKX POMT2 SEMA5A SPON2 SEMA5B SPON1 THSD7B TLR1 POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 S100A9 C1GALT1C1 S100A8 ADAMTS2 LTF ADAMTS3 TLR2 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ADAMTS7 SBSPON MUC3A MUC5AC ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 THSD4 ADAMTS10 ADAMTS15 CD4 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 MUC6 PSMD12 GALNT3 MUC17 NOTCH1 PSMD11 C1GALT1 MUC5B PSMD14 MUC20 PSMD13 MUC21 IPO5 RBPJ GRSF1 DLL1 DNAJC3-1 PSMA7 PSMD8 LFNG PSMB6 BRCA2 PSMB7 RAD51AP1 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 XRCC2 PSMB3 PSMD2 PALB2 PSMD3 PSMB1 SLC17A8 PSMD1 IFIT1 IFIT3 IFIT2 ADRM1 VPS36 SNF8 VPS25 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 ATP1B2 MCCC2 BTD ATP1B1 PC PCCA HLCS MCCC1 PCCB ACACA RAF1 SLC5A7 YWHAB HSPA1A;HSPA1B ELAVL1 XPO1 AKT1 NUP214 YWHAZ XRN1 FXYD4 FXYD3 FXYD1 HSPA8 PABPC1;PABPC3 FXYD6 MAPK14 EIF4G1 RBX1 GNAS-1 ADCY9 ATP1A4 ATP1A3 PRKAR1B ATP1A2 PRKAR1A ATP1A1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 ATP1B3-1 FXYD2;FXYD6-FXYD2 PRKAR2A CSNK1A1 CLCN6 ITCH SLC35A1 B4GAT1 DAG1 FKBP1A LARGE1 CD3G CYSLTR1 CYSLTR2 POMGNT1 GNAT3 SYK SPRED3 SPRED2 FGR HCK ADORA2B SPRED1 GNAZ GNAI3 HRAS FCGR3A;FCGR3B FYN FCGR1A OPN1SW CUL3 NRAS NF1 MYD88 C3-1 NFKBIB CCNK NUP107 NUP188 CCNT1 IRAK4 GTF2B RCC1 TLR9 BANF1 KPNA1 SUPT16H NUP210 LIG1 LIG4 GTF2F1 HMGB1-1 GTF2F2 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 TSG101 NEDD4L AAAS GTF2E1 EPGN GTF2E2 NUP160 NUP85 ARRB1 TPR CLINT1 NUP88 AP1G1 SUPT4H1-1 AP1S2 XRCC6 NUP155 AP1S1 AP1S3 XRCC4 XRCC5 VTA1 NUP153 AP1B1 SUPT5H AP3B1 CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 RAB5C CHMP2A NMT2 TAF4B FEN1 ELL ELOC-1 TAF7L NUP62 ELOA AP1M2 NELFB ELOB AP1M1 NELFCD NELFA CCR5 NELFE NDC1 SEC13 PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B GOLGB1 RANGAP1 NUP50 SFTPB POM121;POM121C SFTPC CHMP3 NUP54 CSF2RB CSF2RA CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 POLR2A NUP42 IRS2 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B POLR2I RAE1 WNT5A RANBP2 RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 FZD5 NCBP2-1 FZD4 TAF8 FZD7 TCEA1 FZD6 TAF7 FZD8 UBAP1 NUP35 ARRB2 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 IDUA HEXB NCAN HEXA BGN VCAN GLB1 HYAL1 IDS CSPG5 GUSB ARSB CHUK UBA7 TRIP11 HSPA5 DDX58 EIF2AK3 ISG15 UBE2L6 HERC5 IFIH1 IKBKB TRIM25 ARIH1 IKBKG CLTC CLTA AP2A1 AP2B1 KEAP1 AP2A2 AP2S1 SH3GL2 AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E CDC37 ERBIN ATG7 PHB ITGB1 FGF2 JAG1 ALK LMO7 IRS1 PIK3R2 PIK3CB PIK3R1 CUL5 UBA6 MYC UBA5 JAK3 UBR4 FRS2 PIK3CA PTPN6 TNRC6C MOV10 AGO4 AGO2 AGO3;AGO1 TGFB1 CCND1 KRAS RUNX1 UBA3 UBA1 CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 RNF213-2 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PATJ ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 RPS15 RPS14 GJA1 RPS17 TBK1 RPS16 SNRPD2 RPS19 SNRPD1 RPS18 AKT2 AKT3 SNRPD3 RPS11 B2M RPS10 VPS39 RPS13 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ST6GAL1 MOGS ATG14 ACE2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 VPS11 ST3GAL4 SNRPE-2 GOLGA2 SFN RIPK3 CDC25A ST3GAL1 CDC25B ST3GAL2 ST3GAL3 PRIM2 VPS16 PRIM1 MLKL SRPK2 POLA1 EDEM2 POLA2 PARP16 GSDME PARP14 SRPK1 PARP10 RPS25 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 NRP1 MAGT1 IKBKE JAK1 PDGFRA TOMM70 FGF6 PARP6 PARP4 PTBP1 PRMT1 RIPK2 SFTPD HNRNPH1 ANO8 ESRP1 HNRNPA1-1 ANO9 ANO6 HNRNPM TYK2 ANO4 CTNND1 PARP9 IL17RC ANO5 CBLL1 EPS15 ANO2 PARP8 IL17RA ANO3 MYO10 ANO1 MYO5A SIKE1 MYO1C SMN2;SMN1 CANX TLR8 TLR7 ZDHHC20 TMPRSS2 RPS27L RNF135 RPS15A GPC1 MGAT5 RPS3 GPC3 ANO10 GPC2 GPC5 MGAT1 GPC4 RPS2 MGAT2 GPC6 STAT1 STAT2 SEC24D-1 MPP5 TJP1 NLRP12 ZDHHC9 STING1 IL17F FAU AGRN VCP-1 CRB3 IL17A TUSC3 GEMIN2 KPNA2 MAP3K7 GSDMD RPS9 RPS7 CASP9 RPS8 RPS5 VPS33A RPS6 VPS33B RPSA ZCRB1 GOLGA7-1 TUFM TMEM258 GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 GEMIN7 GEMIN8 ISCU IFNAR1 SNRPB ATRX DDX5 FUT8 TKFC IRAK1 IRAK2 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW MAN2A1 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 UVRAG CAV1 MAVS OSTC SQSTM1 STT3A UBE2N FLT3 TAB3 TAB2 STT3B TAB1 GSK3A ST6GALNAC2 TRIM27 HSP90AB1 PRKCSH TNKS MGAT4A-1 RPS4X TNKS2 YWHAQ YWHAH PDPK1 RPS3A DDOST LARP1-1 C3AR1 IRF3 IL18 DAD1 IL1A TRAF3 IL1B MBL2-1 P2RX4 TRAF6 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 GNE NOD2 GANAB EIF4A2 SNRPG-2 EIF4A1 VHL CNBP-1 SEC24B IFNB1-4 SEC24A GALNT1 PTPN11 MGAT4C VPS41 MGAT4B VPS45 SEC24C EIF4E CALM3;CALM1 PABPN1-1 GNGT1 CCNE2 CCNE1 GNG10 GNG2 GNG5 GNG4 GNG8 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GALE SI LCT B4GALT1 MAML2 MAML1 TFDP1 TFDP2 MAML3 NOTCH2 NOTCH3 NOTCH4 SEL1L E2F1 E2F3 JUN SNW1 MAMLD1 SLC24A5 CDKN1B SFPQ-1 RAC1 NRG1 NRG2 EREG BTC NRG3 NRG4 EXOC1 ELMO1 ELMO2 CRK DOCK1 HBEGF GBF1 CBL NTF3 NPLOC4 CDK4 CDK2 UFD1 PSEN2 APH1A APH1B FASN U2AF1L5;U2AF1 EIF4A3 CDC40 PSENEN SRRM1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 SRSF1 U2AF2 DHX38 SRSF11 SRSF4-1 ALYREF RNPS1 ABCD1 CBX1 SLC2A9 FKBP4 KANK1 TRADD LY96 FASLG TRAF2 TICAM1 CASP8 RIPK1 CD14 FADD TLR4 SHC1-1 LYN UBE2D3;UBE2D2 NFKBIA NTRK2 BDNF CDK5R1 GCKR GCK TGFBR1-1 TGFBR2 MAP2K2;MAP2K1 RAP1A MAPK1 BRAF MAPK3 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 SLC34A2 SLC34A1 GZMH;GZMB-1 IFNGR1 IFNGR2 P4HB NTHL1 MED19 MED15 MED18 MED11 ATIC CHST6 PPIB MED26 MED29 MED22 MED25 CYP21A2 MED21 P4HA1 P4HA2 P4HA3 SYT1 CHST3 ABCB11 RPL12-1 SYVN1 DERL2 RNF5 OS9 RNF185 TPST2 FLT3LG PDGFB TPST1 CD19 CD28 STRN GAB2 CD86 KLB PGK1 CD80 PDGFRB FGF19 FGFR4 AKT1S1 G6PC1 TRAT1 RPS6KB2 PIK3AP1 G6PC3 CASP5;CASP4 SP1 OGN TBXAS1 FGFR1OP2 ZC3HAV1 SNAP25 RDH12 JAG2 KPNA4-1 PTEN FN1 PPFIBP1 HYOU1 SHH CPSF2-1 DUSP8 DUSP9 ATL2 NEURL1B CRBN NUDT21 PGM1 HHAT FNTA MSH6 MSH3 LY6E FUS NACA RLBP1 KIAA1549 BCAS2 C1S E2F2 HNRNPA0 HNRNPA3 GPKOW CDC5L PDCD1 KDR TRIM24 ALG8 ALG9 ALG6 ALG2 ALG3 ALG1 DHX9 MC2R BST2 GRB2 SUGP1 IL22 AGTRAP CNKSR2 CNKSR1 NAGS PEX19 AGGF1 PEBP1 IGF1R IL6R DHDDS DNAJB11 PPIE PPIH PPIG SYT2 CD8B;CD8B2 TENT4A GALM-2 MYO18A OMD SUN2 TALDO1 ETV6 WDCP SV2C SV2B SV2A CD9 HNRNPU HNRNPR SLC4A1 SLC4A4 TFG MAP1B CTBP2 CTBP1 BRIP1 WDR61 ICOS NEU1 BTF3 HNRNPL HNRNPK HNRNPD CDKN1C WDR48 WDR33 APBB1IP GAS6 ISY1;ISY1-RAB43 EPCAM MED13L IL10RA EXT1 PHF5A AUP1 IPO7 PAPOLA EXT2 TXNL4A SLC39A4 SNRPN SLCO2A1 RAB5B FAM114A2 MCL1 NCL-1 SLC26A4 SLC26A3 AVPR2 PLRG1 TIRAP DNAJC8 CEBPD CD33-1 FIP1L1 SEC11A SEC11C SNRNP40 DNAJA2 KHK PPIL3 PPIL4 PPIL6 SRRM2 IL1R1 COG1 CRNKL1 NEIL3 GAA NEIL1 TLN1 APRT CSTF3 CSTF2 CD79B AHCY CD79A HIP1 SLC22A12 SLC22A18 CHMP1A HNRNPH2 TLR6 TLR5 LMNA EMC4 SPCS3 GNAI1 SPCS2 CYP17A1 SPCS1 GNAI2 CWC25 PPIL1-1 CWC27 CWC22 ALG14 ALG12 ALG11 PRPF6 PRPF8 CPSF4 CPSF6 CPSF1 CPSF3 CWC15 FGFR3 FGFR2 FNTB;CHURC1-FNTB FGFR1 SLC40A1 CGAS HEPH BLNK RBM5 HGSNAT RFT1 HES5 ARAF C4BPA C4BPB CLDN1 MPRIP LOC110384692;C4A;C4B_2;C4B GBP6 SND1 EML4 ABCB6 DHH SLC5A2 GRPEL1 ABCA3 ABCA4 PMM2 ERLIN1 ERLIN2 CP NAPEPLD NOX4 PQBP1 VAMP1 TLR10 SRRT SLC16A1 HEYL CALR-1 PIM1 KPNA7 KPNA5 KPNA3 S100A1 SNRNP200 PORCN QKI ZC3HC1 GGCX FOXM1 CTNNBL1 KSR1 SIGMAR1 KSR2 PPM1B BIRC6 PRCC GALK1 LRP5 LRP6 SLC12A3 SLC12A1 MERTK KDELR1 PRF1 CYP26B1 GCC2 CCAR1 SLC12A6 TIMD4 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 SYMPK RBM10 SEC31A PAF1 RETREG1 DHX15 GALT DHX16 DERL3 SLC3A2 DERL1 MIB1 DPAGT1 SH3GL3 MPI SH3GL1 ZBP1 SLC5A1-1 WBP11 HNRNPUL1 VCL RTN3 DOLK DDX46 DDX42 LRRFIP1 RBM17 DYNLT1 GALNS BUD31 CYP11B1;CYP11B2 RBM22 BCL2A1 DCTN1 DDX23 CSTF2T RRBP1 GBP7;GBP4 ERLEC1 SMNDC1 U2SURP HBA2;HBA1 FAM131B ABCA12 CLP1 DKK1 DKK2 DKK4 BIN2 TYRO3 BRAP SLC6A5 OGG1 SLC6A2 SLC6A3 GNS MRC1 SLC2A10 MRAS SF3B4 SF3B5 SF3B2 SF3B3 HMOX1 SF3B6 BRD4 DDX3X-1 SF3A3 SF3A1 SF3A2 XAB2 RHAG CLEC5A RPL5-1 RNF43 TCN2 VTN BAG4 BAG2 PAH MPDU1 STRA6 CHERP RCAN3 EIF4G3 EIF4G2 EIF4E3 DUSP16 DUSP10 CX3CR1 SLC24A1 SLC24A4 UNC93B1 CLEC4M;CD209-2 PUF60 SNRPB2 PTPN12 GOLGA4 AQR SLC11A2 NUS1 BCL11A NMI SH3KBP1 PRPF19 ZMYM2 MED28-1 PCF11 AVPR1B KREMEN1 KREMEN2 PAPSS2 AVPR1A PAPSS1 PACS1 RDH5 SLC17A5 MAPRE3 AVP SLC20A2 CUX1 SHOC2 AXL GSS HDLBP EFTUD2 PDIA3 ABCG8 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 97%9754678 SARS-CoV-2 modulates host translation machinery RPS14 GEMIN4 GEMIN5 RPS17 GEMIN6 RPS16 SNRPF SNRPD2 RPS19 GEMIN7 SNRPD1 GEMIN8 RPS18 SNRPB SNRPD3 RPS11 SMN2;SMN1 RPS10 RPS13 RPS12 RPS27L RPS15A RPS3 RPS2 SNRPE-2 RPS4X RPS3A FAU RPS25 RPS27A RPS27 RPS29 GEMIN2 RPS20 RPS21 RPS24 RPS9 RPS23 RPS7 RPS8 RPS5 DDX20 RPS6 RPSA SNRPG-2 RPS15 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI CDS1 PITPNM1 PITPNM3 CDIPT PITPNM2 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids ACOT8 ACOT4 SLC27A2 EHHADH-1 DECR2 HSD17B4 ABCD1 ACAA1-1 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease SOS1 STAT1 PIK3CA KANK1 STAT3 GOLGA4 ETV6 KDR STRN PIK3R2 PIK3CB HRAS PIK3R1 FIP1L1 PDGFRA BIN2 WDR48 NRAS PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%164525 Plus-strand DNA synthesis PPIA PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654689 PI-3K cascade:FGFR1 FRS2 FGF20 GAB1 PIK3CA FGF23 PTPN11 FGF2 FGF22 FGF3 FGF10 PIK3R1 FGF1 FGF6 FGF4 FGF9 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.4 Signaling by Insulin receptor ATP6V0B FGF20 SOS1 FLT3LG FGF23 INSR GRB10 ATP6V1B2 ATP6V0C ATP6V1B1 AKT2 GAB2 FGF2 KLB PDE3B IDE PTPRF INS;INS-IGF2 FGF19 ATP6V1G3 FGFR4 IRS2 FLT3 PIK3R4 THEM4 ATP6V0E2;ATP6V0E1 PDPK1 IRS1 PIK3C3 PIK3R2 PIK3CB HRAS PIK3R1 FGF6 NRAS FRS2 GAB1 PIK3CA PTPN11 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 CTSD TLR9 FGF7 ATP6V1H FGF22 FGF3 SHC1-1 FGF10 ATP6V0D1 ATP6V0D2 ATP6V1A ATP6V0A2 ATP6V0A4 ATP6V1D PTPN1 ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 ATP6AP1 TRIB3 MAPK1 MAPK3 TCIRG1 FGF1 FGF4 FGF16 FGF9 FGF18 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9033807 ABO blood group biosynthesis FUT2 FUT1 CASP4 INFLAMMASOME ASSEMBLY%REACTOME%R-HSA-9948001.1 CASP4 inflammasome assembly CALM3;CALM1 SERPINB1 CASP5;CASP4 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-HSA-9623433.2 LXRs regulate gene expression to control bile acid homeostasis NR1H3 RXRA FABP6 NCOR2 RXRB NCOA1 NR1H2 NCOR1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs CPSF1 NCBP1 CPSF3 CSTF3 PAPOLA CSTF2 NCBP2-1 CSTF2T SYMPK CPSF2-1 CPSF7 PCF11 PABPN1-1 NUDT21 CLP1 FIP1L1 WDR33 CPSF4 VITAMINS%REACTOME DATABASE ID RELEASE 97%211916 Vitamins CYP24A1 CYP2R1 CYP26B1 CYP27B1 CYP26A1 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 97%114516 Disinhibition of SNARE formation PRKCA STXBP3 STX4 PRKCB PRKCG SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CSNK2A2 RBX1 PSMC3 PSMA1 YWHAG PSMC4 PSMC1 CSNK2A1;CSNK2A3 CCND1 CSNK2B SPOP UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 CDK4 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 CD274 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 CUL3 PSMC2-1 PSMA2-1 PSMA5 SEM1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 97%372708 p130Cas linkage to MAPK signaling for integrins FGG ITGA2B TLN1 VWF BCAR1 SRC FN1 RAP1A ITGB3 CRK PTK2 FGB FGA RAP1B APBB1IP DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS SFTPC ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%168275 Entry of Influenza Virion into Host Cell via Endocytosis CLTC CLTA AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 97%445717 Aquaporin-mediated transport GNG10 GNAS-1 GNG2 GNG5 ADCY9 GNG4 PRKAR1B GNG8 PRKAR1A ADCY4 ADCY3 AVPR2 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 RAB11FIP2 ADCY5 GNG13 MYO5B PRKACB-1 MIP AQP8 AQP10 GNB2 AQP9 PRKAR2A AQP6 GNB1 RAB11A AQP11 AQP4 GNB4 AQP5 GNB3 AQP2 GNGT1 AQP3 LOC100509620;LOC112267859;AQP7 GNB5 AQP1 PRKAR2B AVP PRKACA-1 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters SLC12A3 SLC12A1 SLC12A6 SLC12A2 SLC12A4 SLC12A5 SLC12A7 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 97%5579031 Defective ACTH causes obesity and POMCD MC2R POMC ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%2122948 Activated NOTCH1 Transmits Signal to the Nucleus MIB2 DLL4 NUMB PSENEN NEURL1 MIB1 DTX1 DTX2 JAG1 UBA52 ARRB1 DTX4 ADAM10 NOTCH1 DNER DLK1 ADAM17 CNTN1 ITCH DLL1 JAG2 PSEN1 RPS27A NCSTN PSEN2 ARRB2 UBB;UBC NEURL1B APH1A APH1B MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 97%5389840 Mitochondrial translation elongation MRPS17 GFM1 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPS36 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 OXA1L AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 TUFM AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 HSPA1A;HSPA1B HSPB1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 HSPA8 PSMB1 PABPC1;PABPC3 PSMD1 ADRM1 EIF4G1 PSMC2-1 PSMA2-1 PSMA5 SEM1 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 97%110312 Translesion synthesis by REV1 RPA1 RPA2 RPA3 RFC5 RPS27A RFC3 RFC4 RFC2 UBB;UBC REV1 RFC1 MAD2L2 REV3L PCNA UBA52 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors FTH1 MASP1 APOB APOA1 CALR-1 COL1A1 COL1A2 COL3A1 COLEC12 APOE MSR1 COLEC11 FTL-1 SCARA5 HSP90B1 COL4A2 MARCO COL4A1 SCGB3A2 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 97%9734779 Developmental Cell Lineages of the Integumentary System EGF FGF10 AREG TGFA PRL AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol GSK3A BAD CDKN1A MDM2-2 CDKN1B AKT2 AKT3 CHUK GSK3B CASP9 AKT1S1 MKRN1 AKT1 TSC2 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME%R-HSA-9665247.2 Resistance of ERBB2 KD mutants to osimertinib CDC37 ERBB2 ERBIN HSP90AA1 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 97%180689 APOBEC3G mediated resistance to HIV-1 infection PSIP1 BANF1 PPIA SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 SPINT1 HPN MST1 MST1R SPINT2 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9865881 Complex III assembly UQCR10 UQCRC1 UQCRC2 TTC19 LYRM4 HSCB LYRM7 UQCRB BCS1L UQCRFS1 C12orf73 UQCC3 UQCC2 UQCC1 HSPA9 SMIM4 LETM1 UQCRQ UQCR11 FXN CYC1 SIGNALING BY ERBB2 IN CANCER%REACTOME%R-HSA-1227990.6 Signaling by ERBB2 in Cancer GAB1 SOS1 PIK3CA PTPN12 HSP90AA1 NRG1 NRG2 EREG BTC EGF CDC37 SHC1-1 ERBIN NRG3 ERBB2 NRG4 PLCG1 EGFR HRAS PIK3R1 HBEGF NRAS RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%111457 Release of apoptotic factors from the mitochondria GSDMD BAX DIABLO-1 BAK1 GSDME CYCS-1 INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769735 Initiation of coagulation cascade HSPG2 GPC6 F2 F3 F5 F7 F8 VWF F9 SERPINC1 AGRN F10 SDC1 GPC1 SDC4 PROS1 GPC3 SDC2 GPC2 SDC3 GPC5 GPC4 PYROPTOSIS%REACTOME DATABASE ID RELEASE 97%5620971 Pyroptosis CASP3 GZMH;GZMB-1 BAX CHMP3 CHMP6 CHMP7 HMGB1-1 CHMP4C CHMP4B CHMP4A CASP5;CASP4 TP63 IRF1 IRF2 GSDME CYCS-1 CHMP2B IL18 CASP1 IL1A IL1B CHMP2A TP53 ELANE GSDMD BAK1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy ATP6V0B ATP6V0E2;ATP6V0E1 ATP6V1H ASAH1 ATP6V1B2 ATP6V1E1 ATP6V0C ATP6V0D1 ATP6V1C1 ATP6V1G1 ATP6V1A E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins PRKDC UBE2D3-1 TMEM129 HLTF RNF152 SHPRH CTR9 UBE2B PEX10 RTF1 PEX2 PEX12 CDC73 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PEX13 PEX14 LEO1 RNF40 RNF144A SELENOS PAF1 WAC-1 RNF181 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E RAD18 DERL1 BCL10 H2BC15;H2BC3;H2BC11;H2BC12 UBE2N H2BC5 PCNA UBE2D3;UBE2D2 UBA52 H2BC1 UBE2D1 RRAGA VCP-1 RPS27A UBE2E1 UBB;UBC UBE2J2 WDR61 UBE2V2 RNF20 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 97%2408552 Methylation of MeSeH for excretion INMT EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 N6AMT1 RPS11 GSPT2 RPL10A GSPT1 RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 APEH ETF1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 TRMT112 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling GGT5 GGT7 CNDP2 GGT6 CHAC2 CHAC1 GGCT GCLC GCLM GSS GGT1 OPLAH ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 97%5662853 Essential pentosuria DCXR INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 97%8985947 Interleukin-9 signaling STAT1 STAT5A STAT3 IL9 STAT5B IL9R IL2RG JAK1 JAK3 BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation EPCAM UPK1A FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190371 FGFR3b ligand binding and activation FGF20 FGF1 FGF9 FGF18 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5687613 Diseases associated with surfactant metabolism SLC34A2 SFTPB SFTPC CSF2RB CSF2RA ABCA3 SFTPD MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%5660489 MTF1 activates gene expression CSRP1 SNCB MTF1 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME DATABASE ID RELEASE 97%9694686 Replication of the SARS-CoV-2 genome RB1 DDX5 ZCRB1 VHL ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility NRG1 NRG2 RHOA EREG BTC EGF NRG3 ERBB2 NRG4 EGFR MEMO1 DIAPH1 HBEGF SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer CBL GAB1 SOS1 PIK3CA HSP90AA1 EGF CDC37 SHC1-1 PLCG1 EGFR HRAS PIK3R1 NRAS TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) VAMP2 VAMP1 SV2C SV2B SV2A DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 97%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.8 Processing of Capped Intron-Containing Pre-mRNA TRA2B SNRPD2 SNRPD1 SNRPD3 SNRPE-2 PTBP1 PPP1CB HNRNPH1 HNRNPA1-1 HNRNPM PPP1CA RBMX UBA52 NUP214 RPS27A UBB;UBC HSPA8 ZCRB1 SNRPF SNRPB DDX5 HNRNPC TCERG1 GPATCH1 PNN METTL3 CXorf56-1 ZNF830 SF1 SLBP DHX8 PRKRIP1 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PRPF38A SMU1 PPP1R10 NKAP UBL5 CPSF2-1 PRPF40A GCFC2 PRPF18 SDE2 TUT1 FAM32A NUDT21 CACTIN SRSF10 SRSF12 PRPF31 PDCD7 RBMX2 FUS PAPOLG SNRPG-2 SNIP1 SNRNP35 IK BCAS2 PRPF4B LENG1 PRPF4 PRPF3 HNRNPA3 SNRNP27 GPKOW SNRNP25 CDC5L NUP107 SNRPC NUP188 SNRPA PPP1R8;STX12 ZMAT2 ZMAT5 CCDC12 YJU2 EIF4E LSM5 NUP210 LSM4 DHX9 LSM3 LSM2 GTF2F1 LSM8 GTF2F2 LSM7 NUP93 SUGP1 LSM6 PABPN1-1 RBM25 NSRP1-1 PPWD1 DDX41 NUP205 USP39 SART1 METTL14 AAAS SNRNP70 TFIP11 SYF2 NUP160 LUC7L3 NUP85 PPIE C9orf78 PPIH TPR WBP4 NUP88 PPIG ZRSR2-1 RNF113A RBM39 NUP155 PPIL2 WTAP MFAP1 ACIN1 NUP153 RBM42 BUD13 HNRNPF SNRNP48 HNRNPA2B1 POLR2J;POLR2J2;POLR2J3 FAM50A HNRNPU HNRNPR SNRPA1 NUP62 HNRNPL XRN2 HNRNPK HNRNPD WDR33 NDC1 SEC13 ISY1;ISY1-RAB43 NCBP1 NUP133 PHF5A PAPOLA TXNL4A NUP50 POM121;POM121C SNRPN NUP54 PLRG1 DNAJC8 POLR2A FIP1L1 NUP42 POLR2B POLR2C SNRNP40 POLR2D PPIL3 PPIL4 NUP43 SRRM2 POLR2G POLR2I CRNKL1 RAE1 RANBP2 CSTF3 CSTF2 NCBP2-1 HNRNPH2 NUP35 CWC25 RBBP6 PPIL1-1 CWC27 CWC22 NUP37 PRPF6 PRPF8 CPSF4 CPSF1 SNW1 CPSF3 CWC15 RBM5 SF3B1 PQBP1 SRRT MTREX SNRNP200 CTNNBL1 PRCC NXT1 CCAR1 U2AF1L5;U2AF1 EIF4A3 CASC3 GLE1 NXF2;NXF2B;NXF5-1 THOC1 PCBP1 THOC3 PCBP2 THOC2 SYMPK THOC5 CDC40 RBM10 THOC7 THOC6 SRRM1 DDX39A DHX15 DDX39B DHX16 SARNP ZC3H11A SRSF2 SRSF3 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 WBP11 RBM8A POLDIP3 SRSF1 NXF1 U2AF2 FYTTD1-1 DDX46 DHX38 DDX42 SRSF11 MAGOH;MAGOHB RBM7 RBM17 SRSF4-1 CHTOP BUD31 ALYREF RBM22 UPF3B RNPS1 DDX23 CSTF2T SMNDC1 U2SURP CLP1 YBX1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3A3 SF3A1 SF3A2 XAB2 POLR2E CPSF7 SAP18 POLR2F POLR2H POLR2L CHERP PUF60 SNRPB2 AQR PRPF19 PCF11 EFTUD2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity ADIPOQ PRKAB2 PRKAA2 ADIPOR1 ADIPOR2 STK11 PRKAG2 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 97%5083636 Defective GALNT12 causes CRCS1 MUC17 MUC5B MUC20 MUC21 MUC12 MUC15 MUC3A MUC5AC MUC1 MUC2 MUC7 MUC4 MUC6 MUC13 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 97%9007101 Rab regulation of trafficking TBC1D25 DENND6B RIN3 RAB38 ULK1 DENND6A RIN1 RIN2 GABARAP AKT2 TBC1D13 AKT3 TBC1D14 RAB5B TBC1D17 RAB6B CCZ1;CCZ1B TBC1D15 TBC1D16 TRAPPC3 TRAPPC1 MAP1LC3B2;MAP1LC3B-1 ANKRD27 DENND4B DENND4A TRAPPC4 TRAPPC5 DENND4C HPS1 RAB39A HPS4 RAB27A RAB39B RAB27B TRAPPC8 TRAPPC9 MON1A MON1B DENND1C DENND1B GDI1 DENND1A GDI2 RAB8B DENND2D RAB4A DENND2C TRAPPC2;TRAPPC2B DENND2B DENND2A RAB3IL1 RAB33A TRAPPC6A TBC1D2 RABEP1 TRAPPC6B RAB7B RAB3IP ARF6 RAB5A RAB1A RABGAP1 YWHAE RAB1B RAB21 GGA2 GGA1 ALS2CL GGA3 CHML RIC1 TRAPPC10 RAB6A RAB33B-1 RAB11B RGP1 RAB10 RAB13 RAB18 RAB3GAP2 RAB3GAP1 RAB8A CHM OPTN-1 SBF1 SBF2 RAB14 AKT1 RAB11A TSC2 TSC1 RAB3A RAB9A RAB9B RAB7A DENND5B RABGEF1 RINL TBC1D10C RAB5C TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TBC1D10A TBC1D10B GABARAPL2 TRAPPC2L ALS2 SYTL1 GAPVD1 RAB32 RAB31 TBC1D20 TBC1D7;TBC1D7-LOC100130357 RAB35 TBC1D24 HSF1 ACTIVATION%REACTOME%R-HSA-3371511.4 HSF1 activation PTGES3-1 HDAC6 HSP90AB1 RPA1 RPA2 YWHAE HSBP1 HSF1 EEF1A1 HSP90AA1 RPA3 VCP-1 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%446107 Type I hemidesmosome assembly LAMA3 DST COL17A1 ITGA6 LAMC2 LAMB3 ITGB4 PLEC CD151 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 97%389977 Post-chaperonin tubulin folding pathway TUBAL3 TUBA1A TUBA1C ARL2 TUBB1 TUBA8 TUBA3E;TUBA3C-1 TUBB2B;TUBB2A TBCD TBCC TBCB TBCA TUBA4A TUBB4B TBCE TUBB4A;TUBB;TUBB8B;TUBB8 TUBB3;TUBB6 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis PIWIL2 PIWIL1 HENMT1 HSP90AA1 ASZ1 POLR2E MAEL TDRKH-1 POLR2F MOV10L1 POLR2H MYBL1 TDRD9 TDRD6 PIWIL4 TDRD1 POLR2L TDRD12 FKBP6 POLR2A PLD6 POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J;POLR2J2;POLR2J3 DDX4 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity MARS1 AIMP1 MARK3 AIMP2 SNAI2 AKT3 EPRS1 GSK3B CDH1 RARS1 SOX9 UBE2I CREBBP QARS1 POMC LARS1 LEF1 SUMO1 YWHAH EEF1E1 YWHAE HDAC1 SIRT1 YWHAG TFEB CTNNB1 WNT3A YWHAB MC4R HINT1 EDNRB PAX3 SOX2 TNFSF11 FOXD3 XPO1 ZIC1 EDN1 KIT EDN3 TFE3 MITF IARS1 SOX10 POU3F2 MC3R TFEC YWHAZ ALX3 TBX3 CSF1 MC1R KARS1 MC5R ID1 EP300 RPS6KA1 MAPK1 DARS1 MAPK3 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin CDC20 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 PTTG1;PTTG2 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 97%389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors HCRTR2 HCRTR1 NPFFR2 NPFFR1 NPFF HCRT QRFPR QRFP APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%111465 Apoptotic cleavage of cellular proteins CASP3 DSP CTNNB1 BIRC2 CASP8 PLEC VIM CDH1 BCAP31 OCLN-1 PRKCQ LMNB1 DSG1 BMX PTK2 SATB1 PRKCD TJP2 DSG2 TJP1 ACIN1 CASP6 PKP1 SPTAN1 DSG3 APC ADD1 CLSPN DBNL GSN STK24 CASP7 FNTA STK26 GAS2 MAPT ROCK1 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 97%4724289 Defective ALG6 causes CDG-1c ALG6 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 97%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 97%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRNB2 CHRNB4 CHRNA3 CHRND CHRNA4 CHRNG CHRNE KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA DIS3 YWHAZ PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 MAPK14 MAPK11 KHSRP AKT1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 97%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC SEC24A SEC24D-1 SEC24C CALR-1 HSPA5 B2M CANX SEC31A PIK3C3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E BECN1 ATG14 SEC23A ERAP2 SAR1B ERAP1 TAP2 TAP1 PDIA3 PIK3R4 TAPBP SEC24B SEC13 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation CDK1 ATM PPP2R1A MTOR MDM2-2 AKT2 AKT3 CCNA2-1 CCNA1 AKT1 MDM4 UBA52 SGK1-1 CHEK2 RICTOR PRR5 DAXX PDPK1 CDK2 PPP2CB;PPP2CA MLST8 PHF20 RPS27A PPP2R5C CCNG1 CDKN2A PPP2R1B MAPKAP1 UBB;UBC TP53 RNF34 USP7 RFFL USP2 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 TKT SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 97%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome SLC25A15 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.3 Constitutive Signaling by AKT1 E17K in Cancer GSK3A RICTOR PRR5 MTOR BAD CDKN1A MDM2-2 CDKN1B PDPK1 AKT2 AKT3 MLST8 CHUK FOXO4 FOXO3 MAPKAP1 FOXO1-1 GSK3B NR4A1 CASP9 AKT1S1 RPS6KB2 AKT1 TSC2 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 97%5579029 Metabolic disorders of biological oxidation enzymes SLC35D1 MAOA UGT1A1;UGT1A6 FMO3 CYP26B1 CYP27B1 TPMT GGT1 CYP24A1 MAT1A CYP21A2 CYP7B1 CYP19A1 CYP11A1 TBXAS1 FDXR CYP1B1 CYP4F22 AHCY GCLC CYP11B1;CYP11B2 GCLM OPLAH CYP27A1 CYP2R1 CYP17A1 CYP2U1 ACY1;ABHD14A-ACY1 GSS FDX1 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA HADH ECHS1 ACADS ACSM3 CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) UHRF1 STPG4 METTL23 DPPA3 H2AC20 KDM6A H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 AICDA TET3 KDM5A H2AC4 KDM5B KDM6B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 H2AC14 H2BC21 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation CD274 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 97%5099900 WNT5A-dependent internalization of FZD4 AP2A2 WNT5A PRKCA AP2S1 FZD4 CLTB ARRB2 CLTC PRKCB CLTA DVL2 AP2A1 PRKCG AP2B1 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.2 Defective FV causes thrombophilia PROC F5 PROS1 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR1C POLR2H POLR1D POLR2L CRCP BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 97%2466712 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD MEIOSIS%REACTOME DATABASE ID RELEASE 97%1500620 Meiosis BLM ACD SPO11 TINF2 SYCP1 SYNE2 TERF2 SYNE1 POT1 SUN1 TERF2IP TEX12 TERF1-1 SMC1B MSH4 MSH5 DMC1 SYCP3-2 PSMC3IP RAD51 SYCE2 SYCE1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I MND1 HSPA2 MLH3 REC8 STAG3 SYCP2-1 H2BC21 RAD51C H2AC20 C1orf112 H2AB2;H2AB3;H2AB1 BRCA2 H2AZ2;H2AZ1 FIGNL1 SMC3 RAD21 RBBP8 STAG1 STAG2 ATM SMC1A RAD50 ATR BRCA1 PRDM7;PRDM9 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LMNB1 FKBP6 TOP3A H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 RPA1 SUN2 RPA2 MLH1 CDK4 CDK2 RPA3 H2AC4 MRE11 NBN H2AC14 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 97%4086400 PCP CE pathway DAAM1 WNT11 WNT4 PRKCG PSMD12 WNT5B RYK-1 PSMD11 WNT5A PSMD14 ROR1 PSMD13 ROR2 PSMA7 WNT1 FZD1 PSMD8 FZD3 FZD2 PSMB6 FZD5 PSMB7 FZD4 PSMD6 FZD7 PSMB4 FZD6 PSMD7 PARD6A FZD8 PSMB5 SMURF2 CLTB PSMB2 SMURF1 ARRB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 PRICKLE1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 SCRIB PSMC1 RAC1 PFN1 RHOA VANGL2 CLTC CLTA AP2A1 UBA52 AP2B1 AP2A2 PRKCA AP2S1 RAC3 RPS27A UBB;UBC DVL1 PRKCB DVL2 DVL3 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants FLT3 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 SOS1 CDC37 SHC1-1 ERBB2 ERBIN PTPN12 HRAS HSP90AA1 NRAS RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 FOXP3 TNFRSF18 IL2RA IL2 CR1L;CR1 IFNG CTLA4 NFATC2 CBFB SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 97%9703648 Signaling by FLT3 ITD and TKD mutants SOS1 PIK3CA PTPN11 NOX4 STAT5A CDKN1A STAT5B GAB2 PIM1 BCL2L1 GRB2 HRAS PIK3R1 FLT3 NRAS SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 97%3304351 Signaling by TGF-beta Receptor Complex in Cancer TGFBR1-1 TGFBR2 SMAD2;SMAD3 FKBP1A TGFB1 SMAD4 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB-1 HADHA ACADVL MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME%R-HSA-9022702.2 MECP2 regulates transcription of neuronal ligands HDAC1 BDNF SST DLL1 SIN3A CRH NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 97%9930044 Nuclear RNA decay NCBP1 WDR82 PABPN1-1 RBM27 ZCCHC7 RBM26 YTHDC1 DIS3 ZC3H4 ZC3H3 YTHDC2 TENT4A TENT4B EXOSC10 RBM7 ZC3H18 SRRT ZFC3H1 EXOSC7 C1D EXOSC6 DXO EXOSC5 MPHOSPH6 EXOSC4 NCBP2-1 EXOSC9 MTREX EXOSC8 EXOSC3 EXOSC2 EXOSC1 ZCCHC8 XRN2 PAPOLG MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation CUL1 BTRC SKP1 CHUK RPS27A FBXW11 NFKB1 UBB;UBC MAP2K2;MAP2K1 MAP3K8 IKBKB MAP2K4 IKBKG TNIP2 UBA52 PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.4 Physiological factors HIPK1 KAT2B HIPK2 WWTR1 MME NPR1 NPR2 NPPC CORIN CES1 TBX5 GATA4 NKX2-5 NPPA ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 97%170670 Adenylate cyclase inhibitory pathway ADCY9 ADCY4 GNAT3 ADCY3 ADCY2 ADCY1 GNAI1 ADCY8 GNAI3 ADCY7 GNAI2 ADCY6 ADCY5 GNAL ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 97%9754706 Atorvastatin ADME ABCB1 PON1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PON3 ABCC2 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell CBL MET EPS15 SH3GL2 SH3KBP1 RPS27A HGS UBB;UBC SH3GL3 STAM SH3GL1 STAM2 UBA52 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 97%5578998 Defective OPLAH causes OPLAHD OPLAH RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706019 RHOBTB3 ATPase cycle HGS RAB9B RHOBTB3 CCNE1 CUL3 LRRC41 PLIN3 RAB9A VHL SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants FGFR2 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 97%73863 RNA Polymerase I Transcription Termination TAF1D TAF1B TAF1C TAF1A CDK7 POLR2E POLR2F POLR2H MNAT1 POLR2L CAVIN1 ERCC3 ERCC2 GTF2H1 GTF2H3 UBTF GTF2H4 TBP TTF1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 CCNH AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification MGST3 GGT5 MGST1 MGST2 GGT7 GGT6 GGT1 AKR7A2 AKR7A3 DPEP2 DPEP1 CYP2A13;CYP2A6;CYP2A7-1 ACY3 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ACY1;ABHD14A-ACY1 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events CASR DGKZ SOS1 LTB4R2 DGKQ DGKK DGKI PIK3R3 DGKH ABHD6 NTS MCHR2 HRH1 GRK5 MGLL TAC3 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2A TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 DAGLB RGS18 RGS17 RGS19 RGS13 RGS16 P2RY6 P2RY2 P2RY1 RGS21 APP CCK KISS1 FFAR3;GPR42 GRK2 EGFR GCGR PRKCE PRKCD PRKCA TRIO RPS6KA3 RPS6KA2 RPS6KA1 ADRA1D ADRA1B ADRA1A TBXA2R CYSLTR1 CYSLTR2 HRAS NRAS SAA2;SAA1 MMP3 GNGT1 PLCB3 PLCB4 PLCB1 PLCB2 GNA14 GNG10 AGT GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 CHRM3 GNG13 GNAQ GNB2 GNB1 GNB4 GNB3 ITPR1 ITPR2 GNB5 ITPR3 MCHR1 GCG MAPK7 BTK KALRN EDNRB HBEGF EDN1 EDN3 NPFFR2 NPFFR1 NPFF HCRT QRFPR QRFP HCRTR2 HCRTR1 FFAR1 OXTR RGSL1 PIK3R2 GRPR EDNRA TRPC7 PROK2 PROK1 PIK3R1 UTS2R TRPC6 PRKCH TRPC3 TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 ARHGEF25 LPAR3 FPR2 LPAR4 PIK3CA NTSR1 NTSR2 GPR17 NMB XCR1 XCL1;XCL2 NMBR LPAR5 LPAR6 NMS NMU GNRH1 MLN BRS3 GPRC6A GPR132 CCKAR GNRHR PRKCQ FFAR4 FFAR2 GAST GPR39 RASGRP2 EDN2 RASGRP1 ANXA1 TACR2 TACR3 TACR1 CCKBR NPSR1 GRP F2R PTGER1 F2 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 KNG1 F2RL1 F2RL2 F2RL3 DGKG AVPR1B DGKE CHRM1 DGKD AVPR1A GPR68 DGKB GPR65 DGKA MAPK1 AVP CHRM5 PMCH MAPK3 ABHD12 RGS4 RGS5 RGS2 RGS3 RGS1 GHSR GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI1 GLI3 GLI2 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 97%9619483 Activation of AMPK downstream of NMDARs CALM3;CALM1 PRKAB1 PRKAB2 PRKAA2 PRKAA1 PRKAG1 CAMKK2 PRKAG3 PRKAG2 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 97%1482801 Acyl chain remodelling of PS PLA2G4A MBOAT1 PLAAT3 OSBPL8 OSBPL5 LPCAT4 LPCAT3 PLA2G1B PLA2R1 PLA1A OSBPL10 PLA2G5 PLA2G2A-1 PLA2G10;LOC100652777 PLA2G2F PLA2G12A PLA2G4F PLA2G2D JMJD7-PLA2G4B;PLA2G4B PLA2G2E PLA2G4D PLA2G4E DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 97%69190 DNA strand elongation LIG1 RFC1 POLD1 PCNA PRIM2 GINS1 RPA1 PRIM1 GINS2 RPA2 CDC45 MCM7 POLA1 MCM8 POLA2 POLD3 GINS3 GINS4 POLD4 MCM3 DNA2 POLD2 RPA3 MCM4 RFC5 MCM5 RFC3 MCM6 RFC4 MCM2 FEN1 RFC2 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 97%5688890 Defective CSF2RA causes SMDP4 SFTPB SFTPC CSF2RB CSF2RA SFTPD INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation GRP GNB3 FFAR1 PCSK1 CDX2 GPR119 ISL1 CTNNB1 GIP DPP4 TCF7L2 LEP GNAT3 SPCS3 GATA4 SPCS2 SPCS1 FFAR4 GNG13 SEC11A SEC11C PAX6 GNB1 GCG ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization SYK SOS1 PIK3CA PIK3R2 PIK3CB PIK3R1 PDPK1 FYN GAB2 LYN LAT2 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%R-HSA-211728.4 Regulation of PAK-2p34 activity by PS-GAP RHG10 ARHGAP10 PAK2 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress CDK6 CDK4 CDKN2A TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.4 Tachykinin receptors bind tachykinins TACR2 TACR3 TAC3 TACR1 TAC1 HDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964011 HDL clearance APOA1 HDLBP AMN CUBN LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-5632681.2 Ligand-receptor interactions BOC GAS1 CDON DHH IHH SHH PTCH1 HHIP RHO GTPASE CYCLE%REACTOME%R-HSA-9012999.4 RHO GTPase cycle ADD3 GJA1 UACA GNA13 TRA2B STOM PTK2B SPEN HSPE1 FMNL3 SLC4A7 FMNL1 FMNL2 VIM CCP110 DOCK7 LBR HSP90AA1 VAPB DOCK10 DOCK11 VCP-1 TIAM2 RACGAP1 DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 CAPZB CAV1 ACBD5-1 HSP90AB1 DOCK2 CDC42 HGS RAB7A LMNB1 PAK2 CCT2 DBT SLC1A5 CCT7 CCT6A MTMR1 IQGAP1 ARHGAP35 RAC1 ARAP1 RHOA ELMO2 DOCK1 LAMTOR1 STEAP3 LETM1 ACTB-1 SRRM1 DDX39B TIAM1 RAPGEF1 FRS3 SOS1 PIK3R3 WASL SHMT2 DDX4 ROCK1 TNFAIP1 ARHGAP5 RND3 ARHGAP21 MUC13 FLOT2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F LEMD3 CKAP4 KTN1 NISCH VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 DSG1 PKP4 RBMX EPHA2 PICALM ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 WASF1-1 TRIO TFRC WIPF1 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L PREX2 PREX1 WDR91 ANKFY1 CEP97 FNBP1 STARD8 NDUFS3 BCR WDR81 DAAM1 NGEF IQGAP2 IQGAP3 ABR MYO6 NCKAP1L STARD13 JUP MCAM FAM135A NOX3 HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 EMD NUDC RRAS2 GMIP CIT CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 CDC42EP1 VAMP3 PKN3 GPS1 KCTD3-1 FGD1 FGD2 FGD3 CUL3 LMAN1 FGD4 RASAL2 FGD5 CHN2 CHN1 STX5 YKT6 FARP2 FARP1 USP9X KIDINS220 MCF2 WWP2 DEF6 WDR11 TMEM59 ABI2 TAOK3 SHKBP1 ABI1 GOPC FILIP1 AAAS PKN2 PKN1 UHRF1BP1L NCF1 FAM13B PLXND1 NCF2 NCF4 FAM13A MSI2 STK10 SLK TPM4 TPM3 RALGAPA1 SWAP70 VRK2 FAM91A1 TEX2 ARMCX3 PHIP RHOBTB1 RHOBTB2 STIP1 DDRGK1 STK38 PLXNA1 ABL2 SRGAP3 SRGAP2 SRGAP1 COPS4 NSFL1C COPS2 NOXA1 PLXNB1 MAP3K11 ZNF512B ACTC1;ACTG2 RASGRF2 SNAP23 ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 NCK2 NCK1 PLEKHG3 PLEKHG4 PLEKHG1 PLEKHG2 PLEKHG6 ARFGAP3 NIPSNAP2 ARFGAP2 LCK DSG2 SOS2 ROCK2 SRC PARD6B PARD6A SH3BP1 ARL13B SLITRK3 NHS SLITRK5 CSK RBBP6 WHAMM WASF2 WASF3 RNF20 PCDH7 CDC42BPB BAIAP2 CDC42BPA CPNE8 GOLGA3 BAIAP2L2 BAIAP2L1 OPHN1 TMPO ACTN1 SPATA13 CFTR GRB7 TMEM87A PTPN13 GARRE1 TWF1 KALRN SCFD1 SPTBN1 STAM CLTC NET1 ANLN FAF2 KIF14 SH3RF1 MTR-1 AKAP12 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 RAC3 SPTAN1 GIT1 VAV3 CCDC115 RALBP1-1 RHOG RHOH RHOF CDC37 RHOC RHOD ERBIN VAV1 VAV2 RHOB RHOJ ARHGEF3 ARHGEF4 ARHGEF1 RHOU ARHGEF2 RHOV ARHGEF7 DBN1 ARHGEF5 RHOQ ITGB1 ARHGEF6 AMIGO2 WAS NOXO1 PAK1 PGRMC2 SAMM50 EMC3 PAK3 PAK5 PAK4 BCAP31 GIT2 CAVIN1 MTX1 MYO9B MYO9A MPP7 DLC1 TRIP10 JAG1 ESYT1 TJP2 RTKN PRAG1 BUB1B-PAK6;PAK6 ARHGDIG ARHGAP39 ACTG1 ARHGAP44 SYDE2 SYDE1 ARHGAP42 BASP1 ARHGDIA PIK3R2 ARHGDIB ARHGEF40 CYBB PIK3R1 CYBA ARHGAP45 ALDH3A2 STAM2 ARHGEF26 ARHGEF25 FRS2 ARHGEF28 ARHGAP19 PIK3CA ARHGAP18 ARHGAP17 ARHGAP15 TOR1AIP1 ARHGAP12 ARHGAP22 ARHGAP20 HMOX2 RHPN2 ECT2 CPSF7 ARHGEF39 ARHGAP29 MACO1 OCRL ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 PLD1 ARHGAP32 DIAPH2 ARHGAP31 PLD2 ARHGAP30 DIAPH3 DNMBP SOWAHC ARHGEF10L RND2 RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 ABCD3 ATP6AP1 ARHGEF15 ARHGEF17 ARHGEF16 ARAP2 ARHGEF19 ARHGEF18 ARAP3 SENP1 ARHGAP10 ZAP70 CKB ALS2 PEAK1 PDE5A CCDC187 MOSPD2 ARHGAP11A-1 FAM169A PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 97%198203 PI3K AKT activation NGF RHOA PIK3CA IRS1 PIK3R2 PIK3CB PIK3R1 IRS2 NTRK1 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane CSNK2A2 CTNNB1 CSNK2A1;CSNK2A3 CANX CSNK2B PCSK6 CDH1 OST4 JUP MOGS SEC11A RPN2 SEC11C OSTC STT3A ARHGAP32 RPN1 PRKCSH FURIN DDOST DAD1 PIP5K1C PCSK7 SPCS3 ANK3 SPCS2 SPCS1 POMT2 GANAB POMT1 TMEM258 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 97%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK6 KCNK7 KCNK1 VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 97%180534 Vpu mediated degradation of CD4 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CD4 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function HDAC1 NFE2 TNRC6C MOV10 TNRC6A-1 AGO4 RBBP5 KAT2B AGO3;AGO1 H2AJ TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CBFB RUNX1 PRKCQ DPY30 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 SIN3B SIN3A PRMT6 H2BC21 SETD1B H2BC1 SETD1A GP1BA ITGA2B WDR5 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EP300 PF4;PF4V1-1 ASH2L ZFPM1 H2AC4 NR4A3 GATA1 KMT2D KMT2A PRMT1 KMT2C KMT2B THBS1 H2AC14 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME DATABASE ID RELEASE 97%5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%5652084 Fructose metabolism SORD AKR1B1 ALDOB ALDH1A1 KHK TKFC GLYCTK SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer SMAD2;SMAD3 SMAD4 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression TP53 PRDM1 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 97%209563 Axonal growth stimulation NGF RHOA ARHGDIA NGFR CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.5 Cleavage of the damaged purine NEIL3 H2AC20 ACD H2AB2;H2AB3;H2AB1 TINF2 H2AZ2;H2AZ1 H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MPG H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 OGG1 H2BC1 H2AC14 H2BC21 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) GRP GNB3 FFAR1 PCSK1 CDX2 GPR119 CTNNB1 DPP4 TCF7L2 LEP GNAT3 SPCS3 SPCS2 SPCS1 FFAR4 GNG13 SEC11A SEC11C PAX6 GNB1 GCG SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 97%177929 Signaling by EGFR ARHGEF7 SOS1 TGFA SH3GL3 SH3GL1 ADAM10 ADAM17 SRC CDC42 EGF CSK PLCG1 HRAS EGFR PIK3R1 PTPRK EPS15L1 EPN1 STAM2 SPRY2 ADAM12 NRAS LRIG1 FAM83D AAMP GAB1 PAG1 PIK3CA FAM83B FAM83A PTPN11 SPRY1 PTPN3 AREG EPS15 EREG HGS BTC SHC1-1 HBEGF STAM EPGN UBA52 PXN CBL PTPN12 SH3GL2 SH3KBP1 RPS27A UBB;UBC ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.2 ERBB2 Activates PTK6 Signaling EREG BTC EGF NRG3 ERBB2 NRG4 PTK6 EGFR HBEGF NRG1 NRG2 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation TPST2 TPST1 ASPH ARSD-1 ARSL ARSJ ARSK ARSH ARSI RIOX2 ARSG ETF1 RPL27A RPL8 U2AF2 RPS23 KDM8 OGFOD1 JMJD4 DHPS FN3KRP JMJD7 ARSB RCCD1 EIF5A2 JMJD6 DNAJC24 DPH1 EEF2 DPH2 DPH5 DPH6 DPH7 ZC3H15 FN3K RWDD1 ICMT EIF5A;EIF5AL1 PROS1 DOHH RIOX1 DRG1 DRG2 SUMF2 SUMF1 STS F2 F7 FURIN F8 F9 F10 PROC GGCX ARSA RPS6 GAS6 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 97%4641265 Repression of WNT target genes TLE4 HDAC1 TLE3 TLE2 CTBP2 TLE1 CTBP1 LEF1 TCF7L1 TCF7 TLE5 TCF7L2 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR NGF NGFR HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation EIF5A;EIF5AL1 DHPS DOHH EIF5A2 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade C1S C3-1 CD19 CFB C4BPA C4BPB VTN LOC110384692;C4A;C4B_2;C4B PROS1 C1QB CPB2 CD81 C1R C5AR2 CFI F2 C5AR1 C8B C8A CPN2 C2 CPN1 CR1L;CR1 C5 SERPING1 CLU C8G C6 C7 C3AR1 C9 CD59 CD55 CR2 CFHR1;CFHR2 CFH-3 ELANE C1QC FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839126 FGFR2 mutant receptor activation FGF20 NCBP1 FGF23 FGFR2 FGF2 POLR2E FGF7 POLR2F POLR2H GTF2F1 FGF22 GTF2F2 FGF3 FGF10 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J;POLR2J2;POLR2J3 NCBP2-1 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764265 Regulation of CDH1 Expression and Function CSNK2A1;CSNK2A3 MOGS H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A RPN2 SEC11C RPN1 PSMD12 PSMD11 PSMD14 PSMD13 SMARCA4 FOXA2 H2AC20 PSMA7 PSMD8 H2AB2;H2AB3;H2AB1 SRC EZH2 PSMB6 TGIF2 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 PCSK7 SPCS3 PSMD3 ANK3 SPCS2 PSMB1 SPCS1 PSMD1 BANP ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CTNND1 PSMC6 MTBP PSMA4 RACK1 CBLL1 SIRT1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 H2AJ TCF12 CANX PCSK6 TLE1 SUZ12 H2BC5 UBA52 H2BC1 KDM1A DNM2 MPHOSPH8 RPS27A H2AC4 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 KMT5A PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 MDM2-2 SNAI1 SNAI2 CTNNA1 CDH1 KLF4 OST4 JUP STRAP OSTC STT3A TWIST2 SP1 H2BC21 VCL PRKCSH EED DDOST H2AZ2;H2AZ1 WT1 ARID1A DAD1 GANAB MYC CTSS HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 ZNF217 TNRC6B CTSB CTSV;CTSL H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 FURIN ZMYM2 CTBP2 CTBP1 MAPK1 POMT2 RB1 MAPK3 POMT1 H2AC14 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones HDAC1 BRMS1 MTA1 SUDS3 HDAC10 RBBP4 NCOR2 RCOR1 SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 SAP18 RBBP7 MTA2 MTA3 HMG20B GPS2 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC18 CHD3 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 HDAC8 H2BC21 H2BC1 KDM1A REST GATAD2B GATAD2A H2AC20 ARID4B H2AC16;H2AC11 H2AC4 ARID4A SAP30 TBL1XR1 PHF21A HDAC2 HDAC3 H2AC14 HEME SIGNALING%REACTOME%R-HSA-9707616.4 Heme signaling RAI1 ARNTL CLEC1B MEF2D MAFK HELZ2 SIRT1 NFE2L2 NRIP1 MED1 CRTC1 LY96 HMOX1 APOB APOA1 PGRMC2 NPAS2 NR1D1 NCOR1 TLR4 PPARGC1A TGS1 CREBBP ATF2 SLC46A1 RORA XPO1 RXRA CLOCK CARM1 CHD9 PPARA HBD;HBB EP300 BACH1 HBA2;HBA1 TBL1XR1 MEF2C NCOA1 NCOA2 NCOA6 CRTC2 SMARCD3 HDAC3 CRTC3 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%1483249 Inositol phosphate metabolism NUP133 INPP5B NUP50 POM121;POM121C INPP5A PLCD3 NUP54 PLCD4 INPP5D PLCD1 INPP5J IP6K1 IP6K3 IP6K2 IPMK NUP42 NUDT11;NUDT10-1 IPPK NUP43 RAE1 RANBP2 PLCE1 PTEN MINPP1 MTMR9 NUP35 SYNJ1 PLCG1 INPP1 MTMR7 NUP37 NUDT4;NUDT4B NUP107 NUP188 PLCG2 INPPL1 ISYNA1 NUP210 PPIP5K1 CALM3;CALM1 PPIP5K2 OCRL NUP93 PLD4 PLCH1 NUP205 PLCH2 AAAS NUP160 NUDT3 NUP85 NUP214 TPR IMPA1 NUP88 IMPA2 NUP155 MIOX ITPK1 NUP153 ITPKB ITPKC PLCB3 PLCB4 ITPKA PLCB1 INPP4A PLCB2 PLCZ1 INPP4B NUP62 NDC1 SEC13 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells EPCAM UPK1A SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665348 Signaling by ERBB2 ECD mutants GAB1 SOS1 PIK3CA HSP90AA1 EGF CDC37 SHC1-1 ERBIN ERBB2 PLCG1 EGFR HRAS PIK3R1 NRAS POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%174411 Polymerase switching on the C-strand of the telomere DSCC1 CHTF18 CTC1 STN1 TEN1 ACD TINF2 TERF2 POT1 TERF2IP TERF1-1 RFC1 POLD1 PCNA PRIM2 PRIM1 POLA1 POLA2 POLD3 POLD4 POLD2 RFC5 RFC3 RFC4 RFC2 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190242 FGFR1 ligand binding and activation FGF20 FGF23 ANOS1-1 FGF2 FGF22 FGF3 TGFBR3 FGF10 GIPC1 FGF1 FGF6 FGF4 FGF9 DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 97%2424491 DAP12 signaling SOS1 PIK3CA TREM2 GRAP2 PLCG2 KLRC4-KLRK1;KLRK1 RAC1 KLRC4;KLRC3;KLRC2;KLRC1 BTK B2M TYROBP KLRD1 LCP2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E LCK VAV3 SYK PIK3R2 PIK3CB PLCG1 HRAS VAV2 PIK3R1 FYN NRAS FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription TXN BCL2L11 FOXG1 AKT2 DDIT3 AKT3 BBC3 STK11 ABCA6 MSTN FOXO1-1 INS;INS-IGF2 KLF4 BCL6 CAV1 PPARGC1A G6PC1 CCNG2 CREBBP CITED2 NR3C1 SIN3A POMC SREBF1 SFN SMAD2;SMAD3 NPY YWHAQ AGRP CAT TXNIP SMAD4 RETN PCBP4 NFYA-1 RBL2 NFYB NFYC HDAC2 GADD45A HDAC1 BTG1 CDKN1A SIRT1 CDKN1B YWHAG FASLG KAT2B FOXO4 FOXO3 ATXN3 YWHAB FBXO32 AKT1 SIRT3 TRIM63 YWHAZ GCK SOD2 IGFBP1 EP300 PINK1 PCK1 PLXNA4 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint PSMA6 CDK1 PSMC5 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 PSMA1 PSMC4 PSMC1 HSP90AA1 GTSE1 FKBPL UBA52 PSMD12 PSMD11 HSP90AB1 PSMD14 PSMD13 CCNB2 PSMA7 CCNB1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC TP53 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PLK1 PSMC2-1 PSMA2-1 MAPRE1-1 PSMA5 SEM1 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex ISCU CHMP3 CHMP2B CHMP6 CHMP7 CHMP2A MAP1LC3B2;MAP1LC3B-1 PIK3C3 CHMP4C CHMP4B BECN1 UVRAG CHMP4A PIK3R4 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 97%5578996 Defective CYP27A1 causes CTX CYP27A1 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 97%73933 Resolution of Abasic Sites (AP sites) TDG LIG1 PARG PNKP POLB POLE MBD4 SMUG1 RFC1 NEIL2 PARP2 APEX1 ADPRS POLD1 LIG3 PCNA PARP1 NEIL1 RPA1 RPA2 NTHL1 POLD3 POLD4 POLD2 RPA3 RFC5 XRCC1 RFC3 RFC4 POLE4 FEN1 RFC2 POLE2 POLE3 MPG OGG1 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME%R-HSA-5619053.4 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839124 FGFR1 mutant receptor activation FGF20 CPSF6 BCR FGF23 PIK3CA CEP43 STAT3 FGFR1 TRIM24 GAB2 FGF2 BAG4 ERLIN2 STAT1 MYO18A LRRFIP1 FGFR1OP2 STAT5A STAT5B ZMYM2 PIK3R1 CUX1 FGF1 FGF6 FGF4 FGF9 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 97%1855229 IP6 and IP7 transport between cytosol and nucleus NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer EREG BTC EGF AREG TGFA EGFR HBEGF EPGN BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins ALOX12 ALOX5 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis DICER1 ANG PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 97%2980736 Peptide hormone metabolism STX1A LHB AGT P4HB ISL1 INS;INS-IGF2 KLF4 ACE2 SEC11A GNG13 SEC11C PCSK2 PAX6 RAB27A ERO1B BCHE CTSZ GNB1 KIF5C ANPEP POMC CPA3 GNB3 INHA SLC30A8 SLC30A5 FSHB ATP6AP2 FFAR1 MYRIP GZMH-1 ENPEP PCSK1 CPB1 PLA2G7 CDX2 GPR119 CRHR2 GIP CLTRN MME DPP4 ACE IGF1 LEP MBOAT4 INHBC GNAT3 INHBE CPE REN SPCS3 SPCS2 SPCS1 GCG CTSG EXOC8 EXOC7 CTSD CGA CTNNB1 MYO5A EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 FFAR4 EXOC1 CPB2 GRP VAMP2 KIF5B KIF5A TCF7L2 CMA1 ACHE CES1 GATA4 TSHB INHBB INHBA INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020956 Interleukin-27 signaling STAT1 TYK2 EBI3 IL27 IL6ST STAT3 CRLF1 IL27RA JAK1 JAK2 CANX SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation TRIM28 NUP133 L3MBTL2 RANGAP1 NUP50 POM121;POM121C NUP54 BMI1 SATB2 RING1 NUP42 PPARGC1A MDC1 CREBBP SATB1 NUP43 RNF2 HDAC7 RAE1 RANBP2 DAXX CBX8 NFKB2 PHC2 PHC1 CBX4 CBX2 PHC3 NUP35 IKBKE CETN2 NUP37 NCOA1 NCOA2 NCOR2 BRCA1 ING2 IKBKG SUZ12 PCNA PCGF2 WRN MITF NUP214 AURKA RPA1 HERC2 UBA2 SAE1 HIPK2 EP300 DNMT1 MRTFA BLM MDM2-2 NPM1-2 CDCA8 CBX5 DDX5 PIAS4 HDAC4 PIAS3 UBE2I HNRNPC THRB CHD3 VDR NR1H2 RORA NR3C1 ESR1 SIN3A PARP1 NR2C1 PIAS1 NR3C2 TRIM27 NR4A2 ZNF350;ZNF432 NR5A1 AR DNMT3B RXRA SUMO1 SUMO3 SUMO2 RARA PGR DNMT3A PPARG INCENP PPARA TP53 BIRC5 SMC5 PARK7 SMC6 SMC3 DDX17 AURKB NSMCE3 RAD21 NSMCE2 HDAC2 VHL NSMCE1 HIC1 STAG1 EID3 ZBED1 STAG2 HDAC1 TP53BP1 SMC1A PML SP3 TOP2A TOP2B MTA1 NUP107 ZNF131 NUP188 SENP5 NRIP1 FOXL2 SENP2 SAFB NSMCE4A TDG TOP1 SP100 NUP210 UHRF2 RNF168-1 CASP8AP2 NOP58 RWDD3 NUP93 MBD1 RAD52 NUP205 AAAS TFAP2C NUP160 NFKBIA NUP85 TFAP2E;TFAP2B TPR NUP88 NUP155 XRCC4 RELA NUP153 XPC CDKN2A CTBP1 EIF2AK2 SENP1 TOPORS NUP62 HNRNPK NDC1 SEC13 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR TLR7 UNC93B1 CTSK CNPY3 TLR3 LGMN TLR9 CTSS CTSB CTSV;CTSL HSP90B1 TLR8 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%5213460 RIPK1-mediated regulated necrosis FLOT2 PDCD6IP TRADD FASLG PRKN TRAF2 PELI1 BIRC2 BIRC3 CASP8 HSP90AA1 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FADD OGT-1 SDCBP UBA52 RIPK3 ITCH MLKL FLOT1 RPS27A UBB;UBC CDC37 STUB1 XIAP TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade S100A8 TLR2 DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 SOCS1 APP NFKB2 TLR6 CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK BTK FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B S100A1 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 SIGIRR IRAK3 FGB NFKBIA FGA FGG RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 S100A9 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 97%4717374 Defective DPM1 causes CDG-1e DPM1 DPM2 DPM3 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654726 Negative regulation of FGFR1 signaling FRS2 CBL FGF20 PPP2R1A FGF23 PTPN11 ANOS1-1 PPP2CB;PPP2CA FGF2 RPS27A FGF22 UBB;UBC FGF3 FGF10 MAPK1 BRAF MAPK3 FGF1 FGF6 MKNK1 FGF4 SPRY2 FGF9 UBA52 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 97%5654743 Signaling by FGFR4 FGF20 FRS2 GAB1 SOS1 PPP2R1A FGF23 PIK3CA PTPN11 FGF2 KLB FGF19 FGFR4 UBA52 CBL PPP2CB;PPP2CA RPS27A UBB;UBC PLCG1 MAPK1 HRAS PIK3R1 BRAF MAPK3 FGF1 FGF6 MKNK1 FRS3 FGF4 SPRY2 FGF16 NRAS FGF9 FGF18 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013424 RHOV GTPase cycle RHOV WDR6 ARHGEF7 DST ARHGAP12 USP9X TXNL1 PAK1 VANGL1 MAP3K11 ZNF512B DEPDC1B PAK4 GIT2 DLG5 NCK2 SPTBN1 NCK1 MYO9A EPHA2 CLTC PAK2 SH3RF1 WASL BUB1B-PAK6;PAK6 SPTAN1 TPM4 GIT1 TPM3 PARD6B CDC42 PARD6A IQGAP1 PIK3R1 PEAK1 CCP110 CEP97 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle PSMC1 CANX MOGS DERL1 UBXN1 NGLY1 MLEC ENGASE UBA52 RAD23B PRKCSH EDEM2 CALR-1 EDEM3 VCP-1 RPS27A AMFR SYVN1 DERL2 EDEM1-1 RNF5 UBB;UBC RNF103 MAN1B1 OS9 RNF139 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 SEL1L GANAB PDIA3 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373755 Semaphorin interactions MYL6 ITGB1 TREM2 LIMK2 LIMK1 PAK1 TYROBP CDK5 PLXNB1 PAK3 GSK3B MYH9 HSP90AB1 TLN1 ROCK2 PIP5K1C ERBB2 NRP1 FYN ROCK1 MET FARP2 ARHGAP35 MYH14 RAC1 MYH11 HSP90AA1 MYH10 RHOA MYL12B CFL1 DPYSL4 DPYSL5 DPYSL2 PAK2 DPYSL3 PLXNC1 SEMA6A SEMA6D CDK5R1 PLXND1 ITGA1 SEMA7A SEMA3A RND1 CRMP1 SEMA3E RRAS ARHGEF11 PLXNA2 PLXNA3 ARHGEF12 SEMA4A CD72 SEMA4D PTPRC FES PLXNB3 RHOC RHOB SEMA5A PLXNA4 PLXNA1 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 FRS2 FGF20 GAB1 PIK3CA FGF23 PTPN11 FGF2 FGF7 FGF22 FGF3 FGF10 PIK3R1 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 PREDNISONE ADME%REACTOME%R-HSA-9757110.4 Prednisone ADME ABCB1 ALB CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 HSD11B1 HSD11B2 SERPINA6 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis MYF6 TCF4 MEF2D ABL1 MYF5 CTNNB1 MAP2K6 TCF12 CTNNA1 MYOG MYOD1 CDC42 NTN3 CDH4 CDON CDH2 BNIP2 CTNNA2 MEF2A NEO1 MAPK14 SPAG9 MEF2C MEF2B;BORCS8-MEF2B MAPK11 MAPK12 CDH15 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME%R-HSA-9615933.2 Postmitotic nuclear pore complex (NPC) reformation NUP133 NUP155 NUP107 SUMO1 NUP188 RANGAP1 POM121;POM121C RCC1 NUP54 NUP35 NUP93 KPNB1 NUP62 RAN NUP205 UBE2I NUP37 NDC1 NUP160 NUP43 AHCTF1 SEC13 NUP85 TNPO1 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 97%112308 Presynaptic depolarization and calcium channel opening CACNA1E CACNB2 CACNB3 CACNB1 CACNA2D2 CACNA1A CACNG2 CACNB4 CACNA2D1 CACNG4 CACNA2D3 CACNA1B DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8863795 Downregulation of ERBB2 signaling USP8 PTPN18 MATK AKT2 AKT3 HSP90AA1 NRG1 NRG2 EREG BTC NRG3 NRG4 HBEGF AKT1 UBA52 PTPN12 RPS27A UBB;UBC EGF CDC37 ERBB2 ERBIN EGFR RNF41 STUB1 CUL5 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ADHFE1 D2HGDH L2HGDH TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 SMARCC1 SMARCC2 CSNK2A1;CSNK2A3 BMI1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RING1 CREBBP CCND3 CCND2 PSMD12 SETD1B SETD1A RNF2 PSMD11 PSMD14 SMARCA2 PSMD13 SMARCA4 CBX8 AUTS2 IL2 IL3 H2AC20 PSMA7 GPAM CBX6 PSMD8 PHC2 H2AB2;H2AB3;H2AB1 LDB1 PHC1 SRC PSMB6 CBX4 PSMB7 PSMD6 CBX2 ELF1 NFATC2 ELF2 PSMB4 PSMD7 ASH2L PSMB5 PHC3 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PRMT1 PSMA2-1 PSMA5 SEM1 ACTL6A PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 TP73 PSMC3 RSPO3 PSMA1 PSMC4 PSMC1 KAT2B H2AJ TCF12 PAX5 TAL1 OCLN-1 H2BC5 PCGF5 MYB UBA52 H2BC1 RYBP SOCS3 CSF2 ITGA2B TJP1 AXIN1 HIPK2 EP300 PF4;PF4V1-1 RPS27A ZFPM1 H2AC4 UBB;UBC GATA2 GATA1 KMT2D KMT2A PRKCB KMT2C KMT2B SPI1 NFE2 CDK6 ABL1 CLDN5 GATA3 CDK7 MNAT1 DPY30 SIN3B CTLA4 ESR1 SIN3A H2BC21 GP1BA SERPINB13 ITCH WDR5 LMO1 LMO2 CR1L;CR1 LIFR KCTD6 H2AZ2;H2AZ1 ARID1A ARID1B NR4A3 SMARCD1 SMARCD2 SMARCD3 THBS1 HDAC1 PML CTSK PTPN11 FOXP3 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 BLK AGO2 RBBP5 AGO3;AGO1 TNRC6B CTSV;CTSL H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 CSNK2B CBFB RUNX1 SOCS4 PRKCQ SMARCE1 H2BC15;H2BC3;H2BC11;H2BC12 PRMT6 PBRM1 YAF2 ACTL6B TNFRSF18 IFNG YAP1-1 IL2RA SMARCB1 CCNH ARID2 LGALS3 H2AC14 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex TICAM2 LY96 TICAM1 RPS27A IRAK2 TRAF6 CD14 UBB;UBC MAP3K7 TLR4 TAB3 TAB2 UBA52 TAB1 REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization PML UBB;UBC NEDD4 PTEN USP7 XIAP RPS27A UBA52 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 97%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists WNT5A WNT9A SFRP1 SFRP2 WIF1 SOST KREMEN1 KREMEN2 WNT3A DKK1 DKK2 DKK4 WNT4 LRP5 LRP6 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.10 tRNA modification in the nucleus and cytosol TYW1;TYW1B TRMT5 TYW3 TRMT12 LCMT2 URM1 WDR4 THADA LAGE3 EPRS1 OSGEP TRMT112 THG1L ALKBH8 TRMT44 C9orf64 TRDMT1 PUS3 TRMT10A METTL1 NSUN2 TPRKB ADAT1 TRMT1 NSUN6 CDKAL1 PUS7 FTSJ1 TP53RK ADAT3 TRIT1 ADAT2 QTRT1 TRMT9B DUS2 QTRT2 CTU2 CTU1 TRMT6 TRMT13 TRMT11 TRMT61A TYW5 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 97%6783310 Fanconi Anemia Pathway FANCD2 ATR FANCI FANCC UBA52 RPA1 RPA2 MUS81 DCLRE1B EME1-1 DCLRE1A FAAP24 SLX4 LOC105377022;FANCB RPA3 EME2 USP1 RPS27A FAAP100 POLN CENPX UBB;UBC FANCM FANCL FANCA FANCE SLX1A;SLX1B ERCC4 FANCG ATRIP FANCF ERCC1 UBE2T FAN1 WDR48 CENPS-CORT;CORT;CENPS SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 97%69052 Switching of origins to a post-replicative state RBX1 CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 PSMA5 ORC1 ORC3 SEM1 PSMA6 ORC2 CDT1 PSMC5 PSMA3 CDC6 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 ANAPC15 ANAPC16 CUL1 UBE2D1 ANAPC10 MCM7 ANAPC11 CDK2 MCM8 FZR1 CDC23 CDC26 CDC27 MCM3 MCM4 ANAPC7 MCM5 RPS27A MCM6 MCM2 UBE2C UBE2E1 UBB;UBC UBE2S CDC16 CCNE2 ANAPC4 CCNE1 ANAPC5 ANAPC1 ANAPC2 DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 97%5679001 Defective ABCC2 causes DJS ABCC2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines CXCR4 CCL3L1;CCL3L3;CCL3;CCL18 CXCL12 CXCL9 CXCL8 CXCL13 CX3CL1 CCRL2 XCR1 CCR9 XCL1;XCL2 CXCL5;CXCL6 CCR8 CCR7 CCR4 CCR3 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 CCL5 CXCR2 CCL1 CCL19 CCL17 CCR10 CCL16 CCR1 CX3CR1 CCL25 CCL22 CCL21 CCL20 PPBP CXCL10 CXCL11 ACKR4 ACKR2 CCL28 CCL27 ACKR3-2 PF4;PF4V1-1 CCR6 CCR2 CCR5 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling CASP10 FADD FASLG CASP8 FAS REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9762293 Regulation of CDH11 gene transcription SNAI1 ZEB2 PRDM8 HEYL ILF3 FOXF1 BHLHE22 SP1 HOXC8 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME DATABASE ID RELEASE 97%5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 HES1 SNW1 HNF1B MAMLD1 NEUROG3 RBPJ KAT2B KAT2A MAML2 EP300 MAML1 ONECUT1 MAML3 CREBBP SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 97%194315 Signaling by Rho GTPases ADD3 GJA1 UACA GNA13 TRA2B STOM PTK2B BUB1 CLASP2 SPEN LIMK2 LIMK1 HSPE1 FMNL3 SLC4A7 FMNL1 PPP1CC FMNL2 VIM PIK3R4 SFN RPS27 YWHAE CCP110 PPP1CB MAPRE1-1 DOCK7 LBR PPP2R1A YWHAG HSP90AA1 PPP1R12A CKAP5 VAPB PAFAH1B1 DYNC1I2 KDM1A DOCK10 DOCK11 KIF5B KIF5A VCP-1 CLASP1 KLC1 DYNC1H1 TIAM2 NDE1 KLC4 PLK1 KLC3 KLC2 RACGAP1 KIF18A DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 CDH1 CAPZB CAV1 ACBD5-1 HSP90AB1 KIF2A YWHAQ YWHAH PDPK1 KIF2C KIF2B DOCK2 CDC42 PIK3C3 CENPE KLK3;KLK2 HGS CALM3;CALM1 RAB7A LMNB1 CFL1 PAK2 CCT2 DBT SLC1A5 H2AC14 CCT7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CCT6A MYH9 MTMR1 H2AC20 H2AB2;H2AB3;H2AB1 IQGAP1 NCOA2 CDKN1B ARHGAP35 RAC1 H2AJ ARAP1 RHOA ELMO2 DOCK1 H2BC5 H2BC1 MEN1 LAMTOR1 H2AC4 STEAP3 LETM1 CDC25C ABL1 ACTB-1 SRRM1 DDX39B PIN1 H2BC21 H2AZ2;H2AZ1 BIRC5 AURKB H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 TIAM1 RAPGEF1 MAPK1 MAPK3 FRS3 S100A9 S100A8 SOS1 PIK3R3 KDM4C-1 BUB1B CDC20 BUB3 MAD2L1 WASL SHMT2 DDX4 ROCK1 TNFAIP1 ARHGAP5 RND3 ARHGAP21 MUC13 FLOT2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F CTNNB1 LEMD3 CKAP4 KTN1 NISCH VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 DSG1 YWHAB PKP4 RBMX EPHA2 PICALM XPO1 PRKCD PRKCA YWHAZ ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 WASF1-1 TRIO TFRC WIPF1 WIPF2 ITSN1 WIPF3 STMN2 FNBP1L MAPK14 MYLK PREX2 MAPK11 PREX1 WDR91 ANKFY1 CEP97 PRKCB FNBP1 STARD8 NDUFS3 MRTFA BCR DYNC1LI1 DYNC1LI2 MYL6 WDR81 DAAM1 NGEF CENPN-2 MIS12-1 CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 SKA2 ABR MYO6 NCKAP1L STARD13 JUP MCAM FAM135A NOX3 HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARPC1B ARPC1A ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 NUF2 EMD NUDC RRAS2 GMIP CIT INCENP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 CDC42EP1 VAMP3 PKN3 GPS1 KCTD3-1 CENPA FGD1 CENPC FGD2 FGD3 CUL3 LMAN1 FGD4 RASAL2 FGD5 CHN2 CHN1 FLNA STX5 YKT6 CENPT FARP2 FARP1 NUP107 CENPU USP9X KIDINS220 MCF2 WWP2 DEF6 WDR11 TMEM59 CENPF CENPH ABI2 TAOK3 CENPI TAOK1 SHKBP1 CENPK ABI1 CENPL CENPM GOPC FILIP1 AAAS PKN2 CENPO PKN1 CENPP NUP160 NUP85 CENPQ UHRF1BP1L NCF1 FAM13B PLXND1 NCF2 NCF4 FAM13A MSI2 STK10 SLK TPM4 TPM3 RALGAPA1 SWAP70 VRK2 FAM91A1 TEX2 ARMCX3 CLIP1 PHIP MAD1L1 LIN7B RHOBTB1 RHOBTB2 STIP1 DDRGK1 DVL1 STK38 DVL2 DVL3 PLXNA1 SEC13 ABL2 SRGAP3 SRGAP2 NUP133 SRGAP1 ARPC4 ARPC5 NDC80 COPS4 RANGAP1 NSFL1C ARPC2 ARPC3 COPS2 NOXA1 PLXNB1 NF2 MAP3K11 ZNF512B ACTC1;ACTG2 RASGRF2 SNAP23 ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 NCK2 SPDL1 NCK1 PLEKHG3 PLEKHG4 ACTR2 PLEKHG1 PLEKHG2 NUP43 PLEKHG6 ARFGAP3 NIPSNAP2 ARFGAP2 LCK RANBP2 DSG2 EVL PPP1R12B PFN2-1 SOS2 ROCK2 SRC SRF ROPN1;ROPN1B NSL1 PARD6B PARD6A SH3BP1 ARL13B SLITRK3 NHS SLITRK5 CSK RBBP6 WHAMM WASF2 WASF3 NUP37 RNF20 PPP1R14A PCDH7 CDC42BPB BAIAP2 CDC42BPA PRC1 CPNE8 GOLGA3 BAIAP2L2 BAIAP2L1 OPHN1 TMPO ACTN1 KNL1 ZW10 SPATA13 BTK PFN1 CFTR GRB7 TMEM87A PTPN13 GARRE1 TWF1 KALRN MYL12B DSN1 SCFD1 SPTBN1 SCAI RCC2 STAM ZWINT CLTC PTK2 NET1 ANLN AHCTF1 FAF2 KIF14 SH3RF1 MTR-1 AKAP12 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 PPP2CB;PPP2CA RAC3 SPTAN1 GIT1 PPP2R5B NDEL1 PPP2R5A VAV3 PPP2R5D CCDC115 PPP2R5C RALBP1-1 PPP2R1B RHOG RHOH RHOF PPP2R5E CDC37 RHOC RHOD ERBIN VAV1 VAV2 RHOB CTTN RHOJ ARHGEF3 ARHGEF4 ARHGEF1 RHOU TAX1BP3 ARHGEF2 RHOV ARHGEF7 DBN1 ARHGEF5 RHOQ ITGB1 ARHGEF6 AMIGO2 WAS NOXO1 PAK1 PGRMC2 SAMM50 EMC3 CTNNA1 PAK3 DYNC1I1 PAK5 PAK4 BCAP31 GIT2 CAVIN1 MTX1 MYO9B MYO9A MPP7 DLC1 TRIP10 JAG1 B9D2 ESYT1 SPC24 SPC25 TJP2 AR ERCC6L RTKN PRAG1 ZWILCH BUB1B-PAK6;PAK6 ARHGDIG ARHGAP39 PMF1;PMF1-BGLAP ACTG1 ARHGAP44 SYDE2 SYDE1 ARHGAP42 BASP1 ARHGDIA PIK3R2 ARHGDIB KNTC1 ARHGEF40 CYBB PIK3R1 CYBA ARHGAP45 SGO1 ALDH3A2 SGO2 STAM2 CENPS-CORT;CORT;CENPS ARHGEF26 ARHGEF25 FRS2 ARHGEF28 ARHGAP19 PIK3CA ARHGAP18 ARHGAP17 ARHGAP15 TOR1AIP1 ARHGAP12 NCKIPSD ARHGAP22 ARHGAP20 MYH14 HMOX2 MYH11 RHPN2 ECT2 MYH10 CPSF7 ARHGEF39 ARHGAP29 MACO1 OCRL ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 PLD1 ARHGAP32 DIAPH2 ARHGAP31 PLD2 ARHGAP30 DIAPH3 DNMBP DLG4 ACTR3-1 SOWAHC ARHGEF10L RND2 RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 ABCD3 ATP6AP1 ARHGEF15 ARHGEF17 ARHGEF16 ARAP2 ARHGEF19 ARHGEF18 ARAP3 SENP1 ARHGAP10 ZAP70 CKB ALS2 PEAK1 PDE5A ITGB3BP CCDC187 MOSPD2 ARHGAP11A-1 FAM169A CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 97%379401 Clearance of dopamine MAOA SLC6A3 COMT LRTOMT HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375281 Hormone ligand-binding receptors LHCGR FSHR GPHA2 FSHB LHB TSHR GNRHR GPHB5 CGA TSHB GNRH1 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters AP2A2 AP1G1 LCK CD8B;CD8B2 AP1S2 AP1S1 AP2S1 AP1S3 CD28 ARF1 AP1B1 B2M ATP6V1H PACS1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD4 AP1M2 AP1M1 AP2A1 AP2B1 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 97%5578997 Defective AHCY causes HMAHCHD AHCY LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux ABCA1 ABCG5 NR1H3 TNRC6C MOV10 APOC1 TNRC6A-1 APOC4 AGO4 AGO2 NCOR2 AGO3;AGO1 TNRC6B NCOR1 GPS2 KDM3A NR1H2 KDM4A APOC2 KDM1A RXRA APOD EP300 KDM1B CETP ARL4C TBL1XR1 EEPD1 ABCG1 RXRB APOE NCOA1 HDAC3 ABCG8 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 97%2980766 Nuclear Envelope Breakdown CDK1 NUP133 NUP107 NUP188 NUP50 POM121;POM121C BANF1 LEMD3 NUP54 NUP210 NUP93 LMNB1 NUP205 NUP42 NEK9 NEK6 AAAS NEK7 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 PRKCA NUP155 CCNB2 EMD CCNB1 NUP153 LPIN1 LPIN2 NUP35 LPIN3 NUP62 VRK1 NUP37 PLK1 LEMD2 CTDNEP1 CNEP1R1 PRKCB NDC1 SEC13 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 97%1295596 Spry regulation of FGF signaling CBL PPP2R1A UBB;UBC PTPN11 MAPK1 BRAF MAPK3 PPP2CB;PPP2CA MKNK1 SPRY2 RPS27A UBA52 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 97%1852241 Organelle biogenesis and maintenance PRKAB2 NOTCH1 HDAC6 DLL1 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 PRKAG2 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG RAB8A CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D ATP5MC2 HAUS6 ATP5MC3 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A ATP5MC1 HAUS1 CEP63 MYB PAFAH1B1 TNPO1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B KIFAP3 HAUS7 CEP70 CHD9 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 MAPK14 ODF2 MEF2C CEP152 MAPK11 NDE1 PLK1 IFT172 TUBB4B CEP97 NEDD1 KIF3B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ CRTC2 ALMS1 CRTC3 KIF3C IFT52 CDK1 IFT57 DYNC2H1 TPTEP2-CSNK1E;CSNK1E IFT140 MEF2D CEP41 CEP43 RPGRIP1L HELZ2 WDR35 IFT88 SMO NRF1 KIF3A TTC21B WDR19 IFT122 MKS1 ALAS1 ATP5PF ATP5PD ATP5PB GRHL1 ATP5PO PRKAA2 ATP5MJ CALM3;CALM1 ATP5MG ATP5ME IDH2 GLUD1;GLUD2 SOD2 CCT3 CCT2 E2F5 TCP1 MAPK12 DMAC2L MED1 CCT8 HCFC1 CCT5 CCT4 PPARGC1A PPARGC1B CREBBP ATF2 ARF4-1 PRKAB1 CYS1 LZTFL1 UNC119B ARL6 ARL3 FBF1 MCHR1 TTBK2 E2F4-1 NPHP1 ESRRA NPHP3 MARK4 RAB11FIP3 ARL13B BBS2 BBS1 TFDP1 RAB3IP BBIP1 AHI1 CEP83 CEP89 C2CD3 NCOA1 GMNN PKD2 NCOA2 PKD1 DYNC2I2 TCTN3 DYNC2I1 TCTN2 NCOA6 TCTN1 TTC26 TRAF3IP1 BBS9 DYNLT2B CNGA2 KIF17 BBS7 HSPB11 CNGA4 DYNC2LI1 BBS5 CC2D2A IFT74 TP73 BBS4 DYNLT5 IQCB1 DYNLT2 IFT80 MKKS EXOC8 IFT20 PRKAG1 EXOC7 IFT22 ACSS2 KIF24 IFT43 IFT81 SSTR3 PRKAG3 BBS10 TTC30A;TTC30B BBS12 TRIP11 NCOR1 IFT27 RP2 DYNLRB2 TMEM216 EXOC4 DYNLRB1 EXOC3 IFT46 EXOC6 CLUAP1 EXOC5 EXOC2 CNGB1 EXOC1 ASAP1 SIRT4 TMEM67 SIRT5 PDE6D RHO SEPTIN2 GBF1 SCLT1 RAB11A SIRT3 ATAT1 TTC8 CEP162 B9D1 CYCS-1 TBL1XR1 MICOS13 MICOS10 MCIDAS RFX2 RFX3 CCNO APOO APOOL MTERF1-1 TFB1M GABPA TFB2M PPRC1 MTX2 GRHL3 GRHL2 INPP5E SAMM50 DEUP1 TFAM-1 CHCHD3 CHCHD6 POLRMT POLG2 GMNC DNAJC11 TMEM11 TWNK MTX1 PERM1 FOXJ1 IMMT SSBP1 TGS1 B9D2 RXRA CAMK4 CARM1 PPARA SMARCD3 HDAC3 ATP5F1A ATP5F1B TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 CRTC1 AGO3;AGO1 TNRC6B ATP5F1C NR1D1 ATP5F1D HSPA9 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 97%9943962 CHD6, CHD7, CHD8, CHD9 subfamily MAFK NFE2L2 NQO1 CTNNB1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 AXIN2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 CHD8 CREBBP CHD7 H2BC5 CHD6 CTCF NKD2 H2BC21 H2BC1 FAM124B IGF2 WDR5 H2AC20 H2AB2;H2AB3;H2AB1 CHD9 H2AZ2;H2AZ1 EP300 H2AC4 DKK2 H2AC14 NUCLEOTIDE BIOSYNTHESIS%REACTOME%R-HSA-8956320.4 Nucleotide biosynthesis ADSS1 PPAT ADSL ADSS2 ATIC GMPS DHODH CAD GART IMPDH1 IMPDH2 PAICS UMPS PFAS G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation GNB3 GNGT1 PDYN GNB5 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 GNG13 OPRM1 GNAQ GNB2 GNB1 POMC GNB4 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 97%389359 CD28 dependent Vav1 pathway CD80 PAK3 LCK VAV1 CD28 FYN PAK1 RAC1 CD86 PAK2 CDC42 VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 97%168268 Virus Assembly and Release CALR-1 CANX HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.8 Hyaluronan degradation HMMR HYAL1 HYAL3 HYAL4 GUSB HYAL2 LYVE1 CHP1 SLC17A5 STAB2 CEMIP HEXB SPAM1 HEXA SLC9A1 CD44 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960519.1 CASP4-mediated substrate cleavage GSDMD CASP3 IL18 CASP5;CASP4 IL1B DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 97%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 POMT2 DAG1 POMT1 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules WAS GRAP2 PLCG2 PAK1 LCP2 PAK3 CD4 NCK1 PAK2 ITK LCK HLA-DPB1-1 HLA-DQB2;HLA-DQB1 EVL CD3E CD3D HLA-DPA1 VASP FYB1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ENAH CD3G HLA-DRA LAT CD101 PLCG1 ZAP70 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation S100A8 TLR2 ITGB5 ITGAV B2M SNAP23 TIRAP HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E STX4 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 TLR6 SEC61A2 PSMB5 MRC2 PSMB2 SEC61A1 VAMP3 PSMB3 PSMD2 SEC61G PSMD3 SEC61B PSME1 PSMB1 PSMD1 CYBB SEC22B CYBA PSMB10 CD36 PSMB8 FCGR1A ADRM1 PSMB9 CD207 CTSS PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 MRC1 PSMC5 PSMA3 PSMC6 MYD88 PSMA4 PSMC3 PSMA1 LY96 PSMC4 PSMC1 CHUK BTK CTSV;CTSL CD14 HMGB1-1 TLR4 IKBKB IKBKG FGB FGA UBA52 NCF1 FGG NCF2 NCF4 CALR-1 VAMP8 PSME2 RPS27A S100A1 UBB;UBC TAP2 TLR1 LNPEP TAP1 PDIA3 TAPBP S100A9 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound KCNMB1 STX1A KCNMA1 CAPZB CACNB2 MYH9 CACNA2D2 SNAP25 EPB41L1 SLC17A8 CAPZA1 RIPOR2 CLIC5 CAPZA2 CIB2 PJVK EPS8 PCLO BSN TPRN PLS1 TMC1 ESPN-1 MYO7A SYP TMC2 MYO3B DNAJC5 MYO3A KCNQ4 FSCN2 MYO1C EZR PCDH15 USH1C ATP2B1 CABP2 TWF1 CABP1 LRRC52 ESPNL CDH23 OTOG CASK OTOF SPTBN1 CHRNA9 CHRNA10 XIRP2 KCNN2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX RAB3A LHFPL5 OTOGL VAMP2 MSN TMIE USH1G STRC SYN1 MYO15A SLC26A5 SPTAN1 CACNA1D GSN SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 MYF6 MYCN TCF4 MYF5 TNRC6C TIMP2 MOV10 TNRC6A-1 AGO4 TIMP1 AGO2 AGO3;AGO1 TNRC6B TGFB1 TCF12 FGF2 PSENEN MYOG HELLS KLF16 TGFBR3 GIPC1 MYOD1 MMP14 MMP16 SP1 ARRB1 ACVR2A INHA SMAD2;SMAD3 RXRA RARA PSEN1 EP300 NCSTN SMAD4 PSEN2 TGFBR1-1 ARRB2 TGFBR2 APH1A APH1B TGFB2 INHBA AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769743 Amplification and propagation of coagulation cascade GP1BA ANO6 F2 F5 F8 VWF F9 SERPINC1 SERPIND1 F10 F11 GP5 GP9 PROC SERPINE2 PROS1 SERPINA5 GP1BB NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) MEF2D EGR1 CDK5 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 CHD4 SH3GL3 ATF2 SGK1-1 REST SRF ID4 JUNB JUND TPH1 PPP2R1A MAPK7 FOSB TCF12 FOS CDK5R1 F3 DNM2 MAPKAPK2 NAB1 ID1 PPP2CB;PPP2CA NAB2 LYL1 ARC VGF EP300 PPP2R5D TRIB1 ATF1 RRAD ELK1 ASCL1 RPS6KA3 PPP2R1B EGR2 RPS6KA5 EGR3 RPS6KA2 EGR4 RPS6KA1 FOSL1 ID3 MEF2A CDK5R2 MAPK1 MAPK14 ID2-1 MEF2C MAPK3 MAPK11 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs PPP1CA ITGB1 ITGB5 ITGB8 PMEPA1 ITGAV ITGB6 TGFB1 PPP1CC UCHL5 TGFBR3 ITGB3 STRAP PPP1R15A USP15 NEDD4L XPO1 UBA52 CBL SMAD2;SMAD3 FURIN FKBP1A RPS27A ITGA8 SMAD4 SMURF2 LTBP4 TGFBR1-1 MTMR4 SMURF1 LTBP2 UBB;UBC TGFBR2 LTBP3 LTBP1 SMAD7 TGFB2 TGFB3 STUB1 PPP1CB BAMBI DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling USP8 UBB;UBC ERBB2 RNF41 AKT2 AKT3 NRG1 AKT1 NRG2 RPS27A UBA52 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 GALM-2 EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids PTGIS TBXAS1 CYP8B1 CYP4B1 CYP4F22 CYP4F3;CYP4F2;CYP4F12;CYP4F11 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 97%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling TRAF6 TLR7 IRF7 MYD88 UBE2V1 IRAK4 UBE2N TLR9 IRAK1 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters SLC15A1 SLC15A3 SLC15A4 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 97%74713 IRS activation IRS1 INSR INS;INS-IGF2 GRB10 IRS2 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-HSA-8981373.2 Intestinal hexose absorption RSC1A1 SLC2A5 SLC5A1-1 SLC2A2 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 97%8982491 Glycogen metabolism PYGL PPP1R3C UGP2 GAA AGL-1 RPS27A PHKG1 PHKB PHKG2 EPM2A CALM3;CALM1 UBB;UBC GBE1 PGM1 GYG2 GYG1 PYGB GYS2 PHKA1 GYS1 PHKA2 NHLRC1 UBA52 PYGM MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a ST3GAL4 ST6GALNAC2 GALNT1 ST3GAL1 ST6GAL1 ST6GALNAC3 ST3GAL2 ST6GALNAC4 ST3GAL3 AFFINITY SELECTION OF IMMUNOGLOBULINS%REACTOME DATABASE ID RELEASE 97%9938027 Affinity selection of immunoglobulins HOXC4 SLAMF6 SPTBN2 SH2D1A EAF1 EAF2 IL21 TNFRSF13C CTSO ACTR1B CTSH CTSF CTSE CTSC RELB HLA-DMA HLA-DMB APEX2 CD40LG CAPZA3 CTSA ACTR10 CD84 LOC102723996;ICOSLG CD4 HLA-DOA HLA-DOB SUPT6H MAF ZBTB17 VCAM1 IRF4 ITGB2 AFF4 TNFSF13B POLI POLH IRF8 DCTN6 DCTN5 STAT6 DCTN4 MLLT1 MLLT3 IWS1 NFKB2 RILP MCM3AP BATF IL4 ACTR1A MAFK CDC73 LEO1 MYB UBA52 DYNC1I2 DIS3 DCTN2 DCTN3 KIF5B KIF5A EXOSC7 KIFAP3 EXOSC6 KIF4B;KIF4A EXOSC5 EXOSC4 KIF20A EXOSC9 RPS27A EXOSC8 CR2 EXOSC3 EXOSC2 UBB;UBC EXOSC1 REV1 DYNC1H1 KLC1 MAD2L2 REV3L KLC4 KLC3 KLC2 RACGAP1 KIF3B KIF3C DYNC1LI1 DYNC1LI2 KIF18A STAT3 KIF11 KIF15 CAPZB KIF3A KIF23 KIF22 KIF2A OSBPL1A CR1L;CR1 KIF2C KIF2B CENPE MSH6 KIF26A CAPZA1 CTSS CAPZA2 E2F2 CTSK C3-1 CCNK CCNT1 CTSD CTSB SUPT16H CTSV;CTSL AICDA GTF2F1 GTF2F2 RAB7A ITGAL SUPT4H1-1 ITGA4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 E2F5 TAF4B ELL ELOC-1 WDR61 TAF7L ICOS ELOA NELFB MEF2B;BORCS8-MEF2B SMARCB1 ELOB NELFCD NELFA NELFE DPF1 DPF2 DPF3 SMARCC1 SMARCC2 CTDP1 PAXIP1 TAF9 POLR2A POLR2B MYH9 POLR2C CREBBP POLR2D SS18L1 POLR2G TAF9B POLR2I SMARCA2 SMARCA4 TAF15 TAF12 CD79B TAF13 CD79A TAF10 TAF11 SSRP1 TAF8 TCEA1 TAF7 ASH2L TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 SS18 NCOA6 ACTL6A PAX5 PCNA PMS2 MLH1 CTNNBL1 KMT2D KMT2C MSH2 ITGB1 CTR9 RTF1 ACTB-1 PAF1 DYNC1I1 BCL6 DPY30 PAGR1 BCL7A BCL7C BCL7B HLA-DPB1-1 WDR5 HLA-DQB2;HLA-DQB1 EXOSC10 EXO1 KDM6A HLA-DPA1 TBP C1D HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 MPHOSPH6 DCTN1 ARID1A HLA-DRA ARID1B RFC5 RFC3 RFC4 RFC2 SMARCD1 CEBPA SMARCD2 JUND SMARCD3 E2F7 E2F8 RBBP5 FOSB POLR2E POLR2F POLR2H POLR2L SMARCE1 RFC1 RELA POLD3 POLD2 NFKB1 ICAM2 IFI30 BACH2 ICAM1 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME DATABASE ID RELEASE 97%5678520 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 97%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 DPAGT1 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME DATABASE ID RELEASE 97%5250968 Toxicity of botulinum toxin type A (botA) SNAP25 SV2C SV2B SV2A SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9663891 Selective autophagy DYNC1LI1 TBK1 DYNC1LI2 ULK1 UBE2V1 IFT88 PRKN CSNK2A1;CSNK2A3 DYNC1I1 MAP1LC3B2;MAP1LC3B-1 PRKAB2 NBR1 PEX5 USP30 SQSTM1 UBE2N HDAC6 PRKAB1 CETN1 TOMM20 TOMM22 VDAC2-1 MAP1LC3A FUNDC1 ATG9A MFN1 ATG12-1 ARL13B MFN2 VDAC3 TOMM40 ATG5 MTERF3 TOMM7 PARK7 TOMM70 PRKAG2 ATM UBE2D3-1 CSNK2A2 PRKAA2 PRKAG1 HSF1 PRKAG3 HSP90AA1 OPTN-1 CFTR CSNK2B PLIN2 UBE2D3;UBE2D2 UBA52 EPAS1 DYNC1I2 PLIN3 VCP-1 RPS27A PCNT UBB;UBC PINK1 HSPA8 VDAC1 DYNC1H1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress NUP133 NUP50 POM121;POM121C NUP54 PTGES3-1 GSK3B AKT1S1 NUP42 HSPA2 CREBBP NUP43 HDAC6 HSP90AB1 RAE1 RANBP2 MLST8 NUP35 YWHAE HSPB8 HIKESHI CCAR2 NUP37 DNAJC2 DNAJC7 FKBP4 CAMK2B ST13;LOC107986532 CAMK2D CRYAB CAMK2A RPS19BP1 HSPA4L HSPA14 HSPA13 ATM DNAJB1 CAMK2G HSPH1 MTOR BAG5 ATR DNAJB6 NUP107 SIRT1 BAG3 NUP188 BAG1 HSBP1 HSPA1L HSF1 HSPA4 HSPA6 EEF1A1 HSPA12A HSP90AA1 HSPA12B RPTOR HSPA5 NUP210 NUP93 BAG4 BAG2 HSPA1A;HSPA1B NUP205 AAAS HSPA9 NUP160 NUP85 NUP214 TPR NUP88 NUP155 RPA1 MAPKAPK2 RPA2 NUP153 EP300 RPA3 VCP-1 HSPA8 NUP62 MAPK1 MAPK3 NDC1 SEC13 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death CD14 RIPK3 FADD TLR4 TICAM2 LY96 TICAM1 CASP8 RIPK1 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013418 RHOBTB2 GTPase cycle HSP90AB1 DBN1 TRA2B TMOD3 MSI2 ACTN1 TXNL1 HSP90AA1 ACTG1 CCT2 CCT7 TWF1 SRRM1 MYO6 CDC37 PHIP DDX39B RHOBTB2 CCT6A HNRNPC RBMX CUL3 STK38 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 97%3656534 Loss of Function of TGFBR1 in Cancer TGFBR1-1 TGFBR2 SMAD2;SMAD3 FKBP1A TGFB1 REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.3 Regulation by c-FLIP TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FADD TRADD FASLG TRAF2 CASP8 TNFSF10 FAS RIPK1 CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 97%8963901 Chylomicron remodeling APOC2 LPL APOA2 APOC3 APOE APOB APOA1 APOA4 APOA5 GPIHBP1 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 97%180746 Nuclear import of Rev protein NUP133 NUP107 NUP188 NPM1-2 NUP50 POM121;POM121C RCC1 NUP54 NUP210 NUP93 KPNB1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 RAN NUP37 NDC1 SEC13 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72163 pre-mRNA splicing TRA2B SNRPD2 SNRPD1 SNRPD3 SNRPE-2 PTBP1 HNRNPH1 HNRNPA1-1 HNRNPM RBMX HSPA8 SNRPF SNRPB DDX5 HNRNPC TCERG1 GPATCH1 PNN CXorf56-1 ZNF830 SF1 DHX8 PRKRIP1 CWF19L2 SNU13 HTATSF1 WDR70 DHX35 PRPF38A SMU1 NKAP UBL5 PRPF40A GCFC2 PRPF18 SDE2 FAM32A CACTIN SRSF10 SRSF12 PRPF31 RBMX2 FUS SNRPG-2 SNIP1 IK BCAS2 PRPF4B LENG1 PRPF4 PRPF3 HNRNPA3 SNRNP27 GPKOW CDC5L SNRPC SNRPA PPP1R8;STX12 ZMAT2 CCDC12 YJU2 LSM5 LSM4 DHX9 LSM3 LSM2 GTF2F1 LSM8 GTF2F2 LSM7 SUGP1 LSM6 RBM25 NSRP1-1 PPWD1 DDX41 USP39 SART1 SNRNP70 TFIP11 SYF2 LUC7L3 PPIE C9orf78 PPIH WBP4 PPIG RNF113A RBM39 PPIL2 MFAP1 ACIN1 RBM42 BUD13 HNRNPF HNRNPA2B1 POLR2J;POLR2J2;POLR2J3 FAM50A HNRNPU HNRNPR SNRPA1 HNRNPL HNRNPK HNRNPD ISY1;ISY1-RAB43 NCBP1 PHF5A TXNL4A SNRPN PLRG1 DNAJC8 POLR2A POLR2B POLR2C SNRNP40 POLR2D PPIL3 PPIL4 SRRM2 POLR2G POLR2I CRNKL1 NCBP2-1 HNRNPH2 CWC25 PPIL1-1 CWC27 CWC22 PRPF6 PRPF8 SNW1 CWC15 RBM5 SF3B1 PQBP1 SRRT MTREX SNRNP200 CTNNBL1 PRCC CCAR1 U2AF1L5;U2AF1 EIF4A3 CASC3 PCBP1 PCBP2 CDC40 RBM10 SRRM1 DHX15 DDX39B DHX16 SRSF2 SRSF3 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 WBP11 RBM8A SRSF1 U2AF2 DDX46 DHX38 DDX42 SRSF11 MAGOH;MAGOHB RBM7 RBM17 SRSF4-1 BUD31 ALYREF RBM22 UPF3B RNPS1 DDX23 SMNDC1 U2SURP YBX1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3A3 SF3A1 SF3A2 XAB2 POLR2E SAP18 POLR2F POLR2H POLR2L CHERP PUF60 SNRPB2 AQR PRPF19 EFTUD2 EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 97%182971 EGFR downregulation ARHGEF7 SPRY1 PTPN3 AREG TGFA EPS15 EREG HGS BTC SH3GL3 STAM HBEGF SH3GL1 EPGN UBA52 CBL PTPN12 SH3GL2 SH3KBP1 RPS27A CDC42 UBB;UBC EGF EGFR PTPRK EPS15L1 EPN1 SPRY2 STAM2 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) VAMP2 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME DATABASE ID RELEASE 97%9854909 Regulation of MITF-M dependent genes involved in invasion DIAPH1 GMPR CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system F2 KLKB1 SERPING1 F12 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling TBK1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 RIPK3 APP NFKB2 IKBKE RIPK2 JUN PPP2R1A MAPK7 BTRC UBE2D3-1 SKP1 BIRC2 CHUK BIRC3 OPTN-1 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 TANK MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 IRF3 TRAF3 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 PTPN11 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP TRAF2 TICAM1 CASP8 LRRC14 USP14 RIPK1 NLRC5 CD14 TIFA FADD HMGB1-1 TLR4 UBE2D3;UBE2D2 NFKBIA UBE2D1 RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 97%5678895 Defective CFTR causes cystic fibrosis PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CFTR DERL3 DERL1 UBA52 PSMD12 ERLIN1 PSMD11 ERLIN2 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 VCP-1 PSMB4 RPS27A PSMD7 DERL2 ERLEC1 PSMB5 PSMB2 RNF5 PSMB3 UBB;UBC PSMD2 OS9 PSMD3 PSMB1 PSMD1 ADRM1 RNF185 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly ERCC2 CIAO3 ABCB7 CIAO1 NDOR1 CIAO2B CIAPIN1 NUBP1 NUBP2 BRIP1 MMS19 POLD1 RTEL1 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.3 Manipulation of host energy metabolism PGK1 ENO1 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 97%9956520 ASS1 variants cause citrullinemia ASS1 NMRAL1 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 97%606279 Deposition of new CENPA-containing nucleosomes at the centromere CENPT CENPU RBBP4 NPM1-2 CENPN-2 KNL1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 HJURP RSF1 CENPH MIS18BP1 OIP5 RBBP7 CENPW CENPI MIS18A CENPK CENPL CENPM H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 CENPO CENPP H2BC21 H2BC1 CENPQ SMARCA5 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CENPX H2AC4 CENPA CENPC RUVBL1 ITGB3BP CENPS-CORT;CORT;CENPS H2AC14 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation FGF20 FGF23 FGFR3 FGF1 FGF4 FGF16 FGF9 FGF2 FGF18 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis ADCY9 PLCG2 PRKAR1B PRKAR1A YES1 ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A LYN IL10 ITPR1 ITPR2 ITPR3 PRKAR2B CD3G AHCYL1 SYK FGR HCK PLCG1 PRKX FCGR3A;FCGR3B FYN FCGR1A PRKACA-1 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME%R-HSA-3560796.4 Defective PAPSS2 causes SEMD-PA PAPSS2 UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases ACTB-1 HCFC1 UCHL5 YY1 OGT-1 USP15 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 H2AC20 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 SMAD7 PSMB1 PSMD1 ADRM1 BARD1 PSMC2-1 PSMA2-1 PSMA5 SEM1 ACTL6A PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 TGFB1 UCHL1 SENP8 NFRKB UCHL3 FOXK2 FOXK1 ACTR5 MBD5 MBD6 ASXL1 ASXL2 MCRS1 BAP1 ACTR8 UBA52 INO80C INO80B INO80E INO80D TFPT RPS27A INO80 H2AC16;H2AC11 TGFBR1-1 KDM1B H2AC4 TGFBR2 UBB;UBC RUVBL1 H2AC14 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants GAB1 SOS1 PIK3CA HSP90AA1 NRG1 NRG2 EREG BTC EGF CDC37 SHC1-1 ERBIN NRG3 ERBB2 NRG4 PLCG1 EGFR HRAS PIK3R1 HBEGF NRAS REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-HSA-912694.3 Regulation of IFNA IFNB signaling IFNB1-4 SOCS3 USP18;USP41 TYK2 STAT2 PTPN6 PTPN11 PTPN1 JAK1 IFNAR1 SOCS1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 97%428542 Regulation of commissural axon pathfinding by SLIT and ROBO DCC ROBO1 ROBO2 NTN1 SLIT1 SLIT2 SRC NELL2 SLIT3 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%416993 Trafficking of GluR2-containing AMPA receptors PRKCA GRIA2 GRIA1 GRIP1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 PICK1 PRKCB AP2A1 PRKCG AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 97%8854518 AURKA Activation by TPX2 CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 HMMR YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 TPX2 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 AURKA HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 97%5250958 Toxicity of botulinum toxin type B (botB) SYT2 SYT1 VAMP2 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding DTNBP1 TPD52L1 PUM1 AP4B1 IGF2R NECAP1 GOLGB1 YIPF6 ACBD3 SNAP23 STX4 CTSZ APP M6PR CLTB PIK3C2A GNS ARF1 HGS OCRL CPD PICALM CLTC GBF1 CLTA AP4E1 ARRB1 CLINT1 AP4M1 AP1G2 AP1G1 FTH1 DNASE2 AP1S2 DNM2 VAMP2 CLVS2 AP1S1 AP4S1 AP1S3 CLVS1 SH3D19 SH3GL2 TPD52 AP1B1 VAMP7 AP3B1 AP3S2;AP3S1 VAMP8 GAK DNAJC6 NAPA RAB5C CHMP2A TFRC TGOLN2 BLOC1S4 BLOC1S6 SNX2 BLOC1S1 HSPA8 BLOC1S3 SNX9 AP1M2 SNX5 TXNDC5 AP1M1 TBC1D8B FTL-1 SNAPIN SORT1 HIP1R DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 97%4549349 Defective ALG2 causes CDG-1i ALG2 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 97%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis NR1H3 RXRA NRIP1 RXRB PCK1 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428559 Proton-coupled neutral amino acid transporters SLC36A1 SLC36A2 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-HSA-5576894.4 Phase 1 - inactivation of fast Na+ channels KCNIP3 KCND1 KCND2 KCNIP1 KCND3 KCNIP2 KCNIP4 RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.6 RHO GTPase Effectors S100A8 BUB1 CLASP2 KDM4C-1 LIMK2 BUB1B LIMK1 CDC20 FMNL3 FMNL1 PPP1CC BUB3 FMNL2 MAD2L1 PIK3R4 SFN WASL RPS27 YWHAE ROCK1 PPP1CB MAPRE1-1 PPP2R1A YWHAG CTNNB1 KTN1 PPP1R12A YWHAB CKAP5 XPO1 PAFAH1B1 DYNC1I2 PRKCD KDM1A PRKCA YWHAZ KIF5B KIF5A CYFIP2 CYFIP1 NCKAP1 WASF1-1 WIPF1 CLASP1 WIPF2 WIPF3 DYNC1H1 KLC1 MAPK14 MYLK MAPK11 NDE1 KLC4 PLK1 KLC3 KLC2 PRKCB MRTFA DYNC1LI1 DYNC1LI2 MYL6 KIF18A DAAM1 CENPN-2 MIS12-1 CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 SKA2 NCKAP1L CDH1 NOX3 NOX1 ARPC1B ARPC1A NUF2 KIF2A YWHAQ NUDC YWHAH PDPK1 KIF2C CIT KIF2B INCENP CDC42 PIK3C3 PKN3 CENPA CENPE CENPC FLNA CENPT NUP107 KLK3;KLK2 CENPU CENPF CENPH ABI2 CALM3;CALM1 CENPI TAOK1 CENPK ABI1 CENPL CENPM GOPC CFL1 PKN2 CENPO PKN1 PAK2 CENPP NUP160 NUP85 CENPQ NCF1 NCF2 NCF4 CLIP1 MAD1L1 LIN7B DVL1 DVL2 DVL3 H2AC14 SEC13 SRGAP2 NUP133 ARPC4 ARPC5 NDC80 RANGAP1 ARPC2 ARPC3 NOXA1 NF2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SPDL1 NCK1 MYH9 ACTR2 NUP43 RANBP2 EVL PPP1R12B H2AC20 PFN2-1 H2AB2;H2AB3;H2AB1 ROCK2 SRF ROPN1;ROPN1B NSL1 IQGAP1 WASF2 WASF3 NUP37 NCOA2 PPP1R14A BAIAP2 PRC1 CDKN1B KNL1 ZW10 RAC1 H2AJ BTK PFN1 CFTR RHOA MYL12B DSN1 SCAI RCC2 ZWINT PTK2 H2BC5 AHCTF1 H2BC1 KIF14 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG MEN1 H2AC4 PPP2R5E RHOC RHOD RHOB CTTN TAX1BP3 CDC25C ABL1 RHOQ ITGB1 WAS NOXO1 PAK1 CTNNA1 ACTB-1 PAK3 DYNC1I1 PIN1 B9D2 H2BC21 SPC24 SPC25 AR ERCC6L RTKN ZWILCH PMF1;PMF1-BGLAP H2AZ2;H2AZ1 ACTG1 KNTC1 CYBB CYBA BIRC5 SGO1 SGO2 AURKB CENPS-CORT;CORT;CENPS NCKIPSD MYH14 MYH11 RHPN2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MYH10 DIAPH1 H2BC15;H2BC3;H2BC11;H2BC12 DIAPH3 DLG4 ACTR3-1 MAPK1 MAPK3 ITGB3BP S100A9 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.8 Costimulation by the CD28 family PIK3R3 PIK3R6 AKT2 PIK3R5 AKT3 CSNK2A1;CSNK2A3 SPOP LOC102723996;ICOSLG CD4 PRKAB2 RPN2 RPN1 PSMD12 PSMD11 PSMD14 PSMD13 LEF1 PSMA7 NFKB2 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 MAGT1 JAK1 ADRM1 PSMC2-1 PSMA2-1 PRKAG2 PSMA5 SEM1 PSMA6 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 MIB2 NEK2 BTRC PSMC3 NFE2L2 PSMA1 BTLA PSMC4 TNFRSF14 YWHAG PSMC1 SKP1 CTNNB1 TCF7 TCF7L1 AKT1 UBA52 STAT1 CUL1 ATF3 PDCD1LG2 VCP-1 RPS27A MAP3K14 DERL2 TUSC3 UBB;UBC RNF5 OS9 MAP3K8 RNF185 TMEM258 CD28 STAT3 RBX1 GRAP2 CD86 CD80 OST4 OSTC STT3A CTLA4 STT3B PDPK1 IRF1 DDOST CD3G DAD1 CDC42 FYN CUL3 PTPN11 PDCD1 PRKAA2 PAK2 YAP1-1 TRIB3 H2AC14 WWTR1 YES1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP LCK PRKAB1 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 ASH2L MAPKAP1 CSK SEL1L JUN TEAD1 PRKAG1 TEAD2 TEAD3 RAC1 H2AJ PRKAG3 TEAD4 FOS SUZ12 H2BC5 EPAS1 H2BC1 ERLIN1 ERLIN2 RICTOR CDK4 PPP2CB;PPP2CA PPP2R5B PPP2R5A EP300 PPP2R5D PPP2R5C PPP2R1B H2AC4 PPP2R5E VAV1 KMT2A KMT2C PAK1 PAK3 GSK3B DERL3 DERL1 DPY30 H2BC21 THEM4 PRR5 HLA-DPB1-1 WDR5 HLA-DQB2;HLA-DQB1 CD3E CD3D HLA-DPA1 EED MLST8 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 H2AZ2;H2AZ1 HLA-DRA PIK3CD ERLEC1 CD274 PIK3CG PIK3R2 B3GNT3 PIK3CB PIK3R1 HIF1A PRKAA1 MYC JUND MYCN PIK3CA MTOR PTPN6 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 BRD4 RBBP5 AGO3;AGO1 FOSB TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 CSNK2B RBBP7 H2BC15;H2BC3;H2BC11;H2BC12 LYN RELA TCF7L2 NFKB1 COPS5 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.5 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) FFAR1 PCSK1 GPR119 ISL1 GIP DPP4 SPCS3 GATA4 SPCS2 SPCS1 SEC11A SEC11C PAX6 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5668541.5 TNFR2 non-canonical NF-kB pathway CD70 TNFSF15 TNFRSF9 TNFSF4 TNFSF9 CD27 TNFSF8 TNFRSF13C LTBR RELB CD40LG TNF TNFSF13B PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 NFKB2 PSMD8 PSMB6 PSMB7 PSMD6 TRAF3 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC TNFRSF1A PSMC3 PSMA1 TNFRSF14 PSMC4 FASLG PSMC1 SKP1 TRAF2 BIRC2 CHUK BIRC3 FBXW11 UBA3 TNFSF11 UBA52 CUL1 TNFRSF18 RPS27A MAP3K14 EDA TNFRSF13B EDA2R TNFRSF8 UBB;UBC TNFRSF4 EDARADD TNFRSF12A TNFRSF1B EDAR LTA TNFRSF25 LTB TNFRSF11B TNFRSF11A TNFRSF17 TNFSF18 TNFSF14 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%R-HSA-211733.3 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 PAK2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand S100A8 FGG TLR2 LBP LY96 APOB GSDME TLR6 S100A1 TLR7 CD14 HMGB1-1 TLR4 GSDMD CD36 TLR1 FGB FGA S100A9 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins TLR2 DEFB129 DEFB128 DEFB127 DEFB106B;DEFB106A DEFB125 DEFB123 DEFB121 DEFB135 DEFB107A;DEFB107B DEFB132 DEFB130B;DEFB130A DEFB105A;DEFB105B DEFB103A;DEFB103B DEFB4A;DEFB4B DEFB1 DEFB109B CCR6 CCR2 DEFB131B;DEFB131A DEFB119 DEFB118 DEFB116 DEFB114 DEFB110 TLR1 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447041 CHL1 interactions ITGA1 HSPA8 ITGB1 NRP1 CNTN6 CHL1 ITGA2 ITGA10 ANK1 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 97%187042 TRKA activation by NGF NGF NTRK1 CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 97%8874211 CREB3 factors activate genes CREB3L4 CREB3L1 CREB3L2 MBTPS2 CREBRF CREB3 DCSTAMP MBTPS1 CREB3L3 SLC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 97%5619102 SLC transporter disorders SLC12A3 SLC12A1 NUP133 SLC34A2 SLC34A1 SLC12A6 SLC6A19 SLC39A4 NUP50 SLC36A2 POM121;POM121C SLCO2A1 SLC6A14 NUP54 SLC7A7 SLC26A4 SLC26A3 AVPR2 SLC7A9 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC3A2 BSG NUP42 SLC5A1-1 NUP43 SLC26A2 RAE1 RANBP2 SLC35A1 SLC35A2 SLC35A3 SLC33A1 SLC22A12 SLC35C1 SLC22A18 NUP35 SLC29A3 SLC27A4 SLC17A8 SLC5A5 SLC2A9 NUP37 SLC6A5 SLC6A2 SLC6A3 SLC2A10 NUP107 SLC24A5 NUP188 SLC40A1 HEPH NUP210 RHAG NUP93 SLC5A7 NUP205 AAAS SLC5A2 NUP160 SLC24A1 NUP85 NUP214 SLC24A4 TPR NUP88 SLC9A6 CP GCKR NUP155 GCK SLC9A9 SLC11A2 NUP153 SLC16A1 SLC2A1 SLC2A2 SLC4A1 SLC4A4 AVPR1B HK1 AVPR1A SLC1A1 NUP62 SLC1A3 SLC17A5 AVP SLC3A1 SLC20A2 SLC6A20 NDC1 SEC13 SLC22A5 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling MET MYL6 RND1 RRAS ARHGEF11 ROCK2 LIMK2 ARHGAP35 LIMK1 MYH14 ARHGEF12 MYH11 RAC1 SEMA4D PLXNB1 MYH10 RHOA RHOC MYL12B ERBB2 RHOB ROCK1 MYH9 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis DGAT2 MOGAT2 MOGAT1 DGAT1 GPAM AGMO LPIN1 LPIN2 LPIN3 GK GPAT2 GK2 MOGAT3 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose DPM1 DPM2 DPM3 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 97%380612 Metabolism of serotonin MAOA ALDH2 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 97%9668328 Sealing of the nuclear envelope (NE) by ESCRT-III TUBAL3 TUBA1A TUBA1C TUBB1 TUBA8 CHMP3 CHMP2B CHMP6 CHMP7 TUBA3E;TUBA3C-1 CHMP2A TUBB2B;TUBB2A IST1 CHMP4C VPS4A SPAST CHMP4B CHMP4A CC2D1B LEMD2 TUBA4A TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TUBB3;TUBB6 DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 97%3656234 Defective HEXA causes GM2-gangliosidosis 1 HEXA LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 97%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex TBL1XR1 GPS2 NCOR2 NCOR1 HDAC3 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME DATABASE ID RELEASE 97%964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1A2 MAN1C1 MAN1A1 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.6 Signaling by NOTCH1 RBX1 CDK8 DLL4 NUMB PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 DTX1 HDAC8 DTX2 JAG1 ADAM10 DTX4 HDAC9 DNER NOTCH1 HDAC6 DLK1 ADAM17 HDAC7 CNTN1 ITCH RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN ARRB2 NEURL1B MAML3 HIF1A MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 TLE4 TLE2 TLE1 UBA52 ARRB1 NBEA CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer HDAC1 IL10RA PTPN6 PRF1 TNRC6C GZMH;GZMB-1 MOV10 STAT3 RBX1 AGO4 NPM1-2 AGO2 SKP1 AGO3;AGO1 IRF4 CEBPB CUL1 STAT5A CCNB1 BCL2A1 JUNB ZC3HC1 FOXM1 MAPK1 ICOS ZAP70 RB1 MAPK3 RPS6 DNMT1 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism AGXT2 UPP1 TYMP NT5C UPB1 NT5E DPYD DPYS NT5C1A NT5M MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 97%9854311 Maturation of TCA enzymes and regulation of TCA cycle ISCA2 CS ACO2 ISCA1 LYRM4 CSKMT SDHAF2 SDHAF3 IDH2 SDHC SDHAF1 SDHD ACAT1 SDHA SDHAF4 FXN SDHB SIRT3 NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 97%9734207 Nucleotide salvage defects HPRT1 APRT ADA PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167290 Pausing and recovery of HIV elongation CCNK CCNT1 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I SUPT4H1-1 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB NELFCD NELFA NELFE RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway ALDH1A2 RDH10 RDH14 RDH13 ALDH8A1 ADH4 CYP26B1 CYP26A1 ADH1C;ADH1B;ADH1A RDH11 RDH5 CRABP1 DHRS3 DHRS4 ALDH1A1 ALDH1A3 SDR16C5 DHRS9 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME DATABASE ID RELEASE 97%8985801 Regulation of cortical dendrite branching ROBO1 ROBO2 NCK2 SLIT1 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling SOS1 EREG BTC SHC1-1 NRG3 NRG4 HRAS HBEGF NRG1 NRAS NRG2 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest E2F8 ARID3A CDKN1A CDKN1B CDK2 CCNA2-1 ZNF385A CCNA1 TP53 PCBP4 CCNE2 CCNE1 E2F1 E2F7 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function RAD17 ATM RAD50 ATR BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN RAD9B KAT5 RAD51B RAD9A RAD51C RPA1 HUS1 RPA2 EXO1 BRCA2 RAD51AP1 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 XRCC2 RFC2 PALB2 BRIP1 MRE11 ATRIP NBN BARD1 RBBP8 SEM1 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9031628 NGF-stimulated transcription MEF2D EGR1 FOSB TCF12 CDK5 CHD4 SH3GL3 FOS ATF2 SGK1-1 CDK5R1 F3 DNM2 REST NAB1 ID1 NAB2 LYL1 SRF ARC VGF EP300 ID4 TRIB1 ATF1 RRAD ASCL1 ELK1 EGR2 EGR3 EGR4 FOSL1 JUNB ID3 CDK5R2 ID2-1 JUND TPH1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 97%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 ARHGAP35 BCAR1 RAC1 RHOA ELMO1 HRAS ELMO2 RASA1 CRK DOCK1 NRAS PXN IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 97%9763198 Impaired BRCA2 binding to SEM1 (DSS1) BRCA2 SEM1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 97%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) MSH2 PMS2 RPA1 RPA2 MLH1 EXO1 POLD3 POLD4 RPA3 POLD2 LIG1 MSH6 POLD1 PCNA RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle BCR ARHGEF5 STOM DAAM1 IQGAP3 ABR ACTC1;ACTG2 SNAP23 STARD13 JUP CAVIN1 MCAM CAV1 MYO9B MYO9A DLC1 ARHGAP1 TJP2 RTKN ARHGDIG ROCK2 ARHGAP39 CIT VAMP3 PKN3 PIK3R2 PIK3R1 ROCK1 ARHGAP5 PCDH7 ARHGAP21 ARHGEF25 FLOT2 ARHGEF28 OPHN1 ARHGAP35 MCF2 RHPN2 ECT2 VANGL1 DEPDC1B ARHGAP26 DIAPH1 ARHGAP32 PKN2 NET1 PKN1 ANLN DIAPH3 SOWAHC ARHGEF10L AKAP13 MCF2L STK10 FLOT1 SLK ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF17 TFRC ERBIN VAV2 RHOB PREX1 ARHGEF3 ARHGEF1 RACGAP1 STARD8 ARHGEF2 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 97%912631 Regulation of signaling by CBL CBL PIK3CA PIK3R3 BLNK YES1 PIK3CD SYK PIK3R2 HCK PIK3CB VAV1 RAPGEF1 PIK3R1 FYN CRK CRKL LYN BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%8851680 Butyrophilin (BTN) family interactions CLEC4M;CD209-2 PPL BTNL9 BTN3A1;BTN3A3 BTN1A1 BTNL2 BTN2A2;BTN2A1 XDH DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 97%68952 DNA replication initiation POLE4 PRIM2 POLE PRIM1 POLE2 POLA1 POLE3 POLA2 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 97%5603029 IkBA variant leads to EDA-ID NFKB1 IKBKB RELA IKBKG NFKB2 CHUK NFKBIA REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.9 Regulation of necroptotic cell death FLOT2 PDCD6IP TRADD FASLG PRKN TRAF2 PELI1 BIRC2 BIRC3 CASP8 HSP90AA1 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FADD OGT-1 SDCBP UBA52 RIPK3 ITCH MLKL FLOT1 RPS27A UBB;UBC CDC37 STUB1 XIAP INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling CA1 STAT3 P4HB GSTA3;GSTA5;GSTA1;GSTA2 AIP JAK2 IL23R IL23A PPIA CDC42 EBI3 IL27 IL6ST CRLF1 IL27RA MTAP JAK1 CAPZA1 RAP1B TYK2 ARF1 RPLP0 GSTO1 CANX PITPNA LMNB1 CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A HSPA9 IL12RB1 PAK2 IL12RB2 IL10 SERPINB2 ANXA2 STAT1 MSN MIF RALA-1 SOD2 TALDO1 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 LCP1 TCP1 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway MAP2K2;MAP2K1 RAF1 MAPK1 BRAF MAPK3 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 97%74751 Insulin receptor signalling cascade FGF20 FRS2 GAB1 SOS1 FGF23 FLT3LG PIK3CA INSR PTPN11 GRB10 AKT2 GAB2 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 SHC1-1 INS;INS-IGF2 FGF10 FGF19 FGFR4 IRS2 FLT3 PIK3R4 THEM4 PDPK1 TRIB3 IRS1 PIK3C3 PIK3R2 PIK3CB MAPK1 HRAS PIK3R1 MAPK3 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 97%380284 Loss of proteins required for interphase microtubule organization from the centrosome CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism CYB5A SLC23A2 GSTO2 SLC23A1 CYB5R3 SLC2A1 GSTO1 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9026527 Activated NTRK2 signals through PLCG1 BDNF PLCG1 NTRK2 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 97%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654710 PI-3K cascade:FGFR3 FRS2 FGF20 GAB1 PIK3CA FGF23 PTPN11 FGF2 PIK3R1 FGF1 FGF4 FGF16 FGF9 FGF18 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors HSPH1 APOB CALR-1 HSP90AA1 SCARF1 HYOU1 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a ST3GAL4 ST6GALNAC2 GALNT1 ST3GAL1 ST6GAL1 ST6GALNAC3 ST3GAL2 ST6GALNAC4 ST3GAL3 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-HSA-196843.4 Vitamin B2 (riboflavin) metabolism ACP5 RFK SLC52A3 ENPP1 SLC52A1;SLC52A2 FLAD1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain PERP TP63 PPP1R13B TP73 NDRG1 CHM BCL2L14 TP53 RABGGTB RABGGTA TP53I3 BCL6 TP53BP2 BIRC5 ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 97%2161541 Abacavir metabolism ADAL NT5C2 PCK1 ADH1C;ADH1B;ADH1A DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 97%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 97%8984722 Interleukin-35 Signalling STAT1 TYK2 EBI3 IL6ST STAT3 IL27RA JAK1 STAT4 JAK2 IL12A CANX IL12RB2 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.4 InlA-mediated entry of Listeria monocytogenes into host cells UBB;UBC CTNND1 CDH1 CBLL1 SRC CTNNB1 RPS27A UBA52 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME DATABASE ID RELEASE 97%9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CDK6 E2F2 CDKN1A CDKN1B CDK4 CDK2 CCND1 TFDP1 TFDP2 CCNE2 CCNE1 RB1 CDKN1C CCND3 E2F1 CCND2 E2F3 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022854 Keratan sulfate biosynthesis SLC35D2 FMOD CHST6 LUM B4GALT6 B4GALT4 B4GALT5 PRELP KERA CHST1 OGN ST3GAL4 CHST2 ST3GAL1 ST3GAL2 ST3GAL3 CHST3 OMD ACAN B4GAT1 B4GALT2 B4GALT3 B4GALT1 B3GNT7 B3GNT4 B3GNT3 B3GNT2 ST3GAL6 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors DIS3L2 PABPN1-1 PABPC1;PABPC3 EIF4A3 EIF4G1 EIF4A2 EIF4E EIF4A1 EIF4B TUT7 PAIP1 TUT4 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate HACL1 SLC27A2 PHYH-4 PECR SLC25A17 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013422 RHOBTB1 GTPase cycle DBN1 TRA2B COPS4 SPEN TXNL1 ROCK2 COPS2 CCT2 CPSF7 CCT7 VIM SRRM1 MYO6 GPS1 RBBP6 RHOBTB1 PDE5A HNRNPC RBMX RNF20 ROCK1 CUL3 STK38 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin RBX1 CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 PSMA5 ORC1 ORC3 SEM1 PSMA6 ORC2 CDT1 PSMC5 PSMA3 CDC6 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 CUL1 MCM7 CDK2 MCM8 MCM3 MCM4 MCM5 RPS27A MCM6 MCM2 UBB;UBC RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol RPS14 NOP56 SNU13 DDX49 NOP2 DDX47 WDR3 FCF1 NAT10 THUMPD1 WDR46 WDR43 RRP9 FBL LOC102724159;PWP2 BUD23 UTP14C;UTP14A UTP15 WDR36 UTP11 DIMT1 IMP3 WDR75 IMP4 DDX52 UTP18 DKC1 NHP2 UTP25 HEATR1 TSR3 NOC4L NOL6 RRP7A EMG1 TRMT112 PDCD11 BMS1 DHX37 RRP36 UTP20 DCAF13 NOP58 NOP14 UTP6 UTP4 KRR1 PNO1 UTP3 RCL1 TBL3 MPHOSPH10 NOL11 NOP10 RPS2 RPS9 RPS7 RPS6 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB NBEA ADCY9 PRKAR2B PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 PRKX ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKACA-1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8941858.3 Regulation of RUNX3 expression and activity PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 MDM2-2 PSMC3 PSMA1 PSMC4 PSMC1 TGFB1 CBFB RUNX3 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 SRC PSMB6 PSMB7 PSMD6 EP300 PSMB4 RPS27A PSMD7 CDKN2A PSMB5 SMURF2 PSMB2 SMURF1 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 97%8953897 Cellular responses to stimuli CSNK2A1;CSNK2A3 HSPE1 RPL10A BMI1 ETS1 RING1 PGD RNF2 HDAC6 CBX8 CBX6 PHC2 PHC1 CBX4 CBX2 PHC3 EGF NFYA-1 RPL36AL-1 YWHAE GFPT1 PRKACA-1 ACTR1A PPP2R1A BTRC APOA1 SKP1 HSP90AA1 AQP8 AJUBA UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 PRKAR2B RPL18A RPS27A RPS6KA3 UBB;UBC RPS6KA2 RPS6KA1 DYNC1H1 MAP2K3 MAP2K4 MEF2C MAPKAPK3 MAPK9 MAPK8 MAP2K7 HSP90B1 MAPK10 TXN HELZ2 STAT3 BCL2 DDIT3 BCL2L1 CAPNS1 CAPNS2 CSRP1 CAPN2 SNCB HSPG2 NFYB NFYC RPL15-1 FOXO3 IDH1 MMP14 GSTA3;GSTA1 ITGA5 SPP1 YAP1-1 RB1 EHMT2 EHMT1 H2AC14 MED1 NOS3 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A CREBBP H2AC20 H2AB2;H2AB3;H2AB1 EZH2 RPL10;RPL10L-1 CAT NCOA1 NCOA2 NCOA6 SIRT1 UBE2D3-1 HSBP1 RPLP0 HSF1 NCOR2 H2AJ NCOR1 RPLP2 RPL36-1 CDKN2B SUZ12 H2BC5 SIRT3 H2BC1 ID1 CYCS-1 EXTL2 IGFBP1 EP300 ADD1 H2AC4 EXTL3 TBL1XR1 FABP1 CDK6 ABL1 RPL22L1 RPL37A-1 GSK3B HSPA2 CITED2 SIN3A H2BC21 EED H2AZ2;H2AZ1 COX4I1 COX4I2 PIK3CD ME1 ARNT CAMK2B CAMK2D CAMK2A RPL13A-1 SMARCD3 HDAC3 HSPD1 CXXC1 CAMK2G RBBP4 CRTC1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 ITGB3 H2BC15;H2BC3;H2BC11;H2BC12 NDUFA4 RPL23A ATP7A DEFA6;DEFA4;DEFA5 ATOX1 RPL27A PSMD12 NOTCH1 PSMD11 PSMD14 P2RY2 PSMD13 PSMA7 DNAJC3-1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PALB2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 ATP6V1E1 PSMC3 ATP6V1E2 PSMA1 ATP6V1G1 PSMC4 ATP6V1G2 PSMC1 CTNNB1 G6PD ATP6V0D1 ATP6V0D2 HSPA1A;HSPA1B ATP6V1A XPO1 KHSRP AKT1 NUP214 DIS3 PRKCD ATP6V1D MAPKAPK2 ATP6V1C1 PARN ATP6V1F EXOSC7 GCLC ATP6V1C2 EXOSC6 GCLM EXOSC5 CHD9 EXOSC4 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 HSPA8 MAPK14 MAPK11 TCIRG1 CRTC2 CRTC3 RAI1 BLVRB ATP6V0B CLEC1B MEF2D ATP6V1B2 BLVRA ATP6V0C RBX1 ATP6V1B1 GNAS-1 ADCY9 PRKAR1B PRKAR1A MBTPS1 ADCY4 RPL26L1 ADCY3 MBTPS2 ADCY2 RPL4 ADCY1 ADCY8 ATP6V1G3 RPL30 ADCY7 RPL3 ADCY6 RPL32 ADCY5 PRKACB-1 RPL31 RPL34 PRKAR2A RPL8 RPL9 RPL6 ATP6V0E2;ATP6V0E1 RPL7 RPL35 RPL38 RPL39 RPL21 RPL23 RPL22 FYN CUL3 RPL24 RPL27 RPL26 RPL29 RPL28 NUP107 NUP188 NUP210 RPL3L NUP93 NUP205 RPLP1-2 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 ELOC-1 NUP62 RPL11 RPL14 ELOB RPL13 RPL18 RPL17 CACNB1 RPL19 CACNA2D1 NDC1 SEC13 NUP133 NUP50 POM121;POM121C NUP54 NUP42 CACNB2 CACNB3 NUP43 RAE1 RANBP2 ASNS NUP35 ALB NUP37 RPL7A GPX1 CXCL8 CHUK HSPA5 CCL13;CCL2 EIF2AK3 TXNRD1 RPL35A IKBKB IKBKG ATF6 FKBP5 SLC46A1 KEAP1 CHAC1 AMER1 TRIM21 PPP2CB;PPP2CA PPP2R5B PPP2R1B STOML2 PHB2 YME1L1 ITGB1 CHD6 PIK3R2 PIK3CB HIF1A CUL7 MYC COX7A2L-1 CUL2 ARNTL PIK3CA TNRC6C MOV10 TNRC6A-1 AGO4 NQO1 AGO3;AGO1 TNRC6B ABCG2 COX7A2 HSPA9 CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 ACADVL CDC27 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ABCC3 ABCC1 RPS15 RPS14 GJA1 RPS17 RPS16 RPS19 RPS18 AKT2 AKT3 RPS11 RPS10 RPS13 PTGES3-1 RPS12 MAP1LC3B2;MAP1LC3B-1 CAPZA3 ACTR10 ZBTB17 DCTN6 DCTN5 DCTN4 PANX1 P2RX7 RPS25 RPS27 TXNIP RPS29 RPS20 SKP2 RPS21 RPS24 RPS23 IKBKE HSPB8 HIKESHI CCAR2 DNAJC2 DNAJC7 ST13;LOC107986532 CRYAB RPS19BP1 HSPA4L HSPA14 HSPA13 DNAJB1 PDGFA HSPH1 BAG5 MAFK AREG DNAJB6 NFE2L2 BAG3 BAG1 HSPA1L HSPA4 HSPA6 HSPA12A EEF1A1 HSPA12B RPS27L RPS15A RPS3 RPS2 STAT1 FAU ATF3 VCP-1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA MAFG ACD TINF2 TERF2 POT1 CREB3 DCSTAMP TERF2IP CREB3L3 TERF1-1 CREB3L4 CREB3L1 CREB3L2 CREBRF NLRP3 CAPZB SQSTM1 GSK3A HSP90AB1 RPS4X PDPK1 RPS3A HBD;HBB IL1A CAPZA1 CAPZA2 VHL IFNB1-4 HIRA EIF2S2 EIF2S3;EIF2S3B EIF2S1 CALM3;CALM1 ATP6V1H LMNB1 ATF5 PPP2R2A;PPP2R2D NPRL2 NPRL3 EIF2AK1 GNGT1 EIF2AK4 ANXA2 H1-0 H1-3 H1-2 H1-5 SOD2 H1-4 SOD1 NOX5 EXTL1 EGLN1 EGLN3 EGLN2 CASTOR1 WTIP CASTOR2 ERO1A FBXL17 SESN1 BACH1 MAP3K5 MUL1 FLT4 ARFGAP1 IMPACT CCNE2 HM13 CCNE1 SH3BP4 SRPRB-1 SLC7A11 NUDT2 MT2A PIEZO1 PREB KDELR3 OMA1 DELE1 FKBP14 HERPUD1 MYDGF MINK1 DEPDC5 RAMP2 GNG10 YIF1A HDGF GNG2 ETS2 GNG5 ERN1 GNG4 HTRA2 GNA11 CACNA1H GNG8 GCN1 HMGA2 MT3 CABIN1 GOSR2 SOD3 CCS BMT2 TSPYL2 DDX11 ASF1A SEH1L GNG13 ABCF2-H2BE1;ABCF2 GNAQ PRDX3 GNB2 SSR1 ATF2 WDR59 GNB1 PRDX6 ADM GNB4 HIF3A GNB3 MIOS KAT5 WDR24 UBN1 GNB5 CDKN2D CDKN2C EPO CDH5 ERF RRAGA TNIK RRAGC CALCRL RRAGB IGFBP7 WFS1 RRAGD TPP1 SRXN1 HIF1AN GPX6 PRKCI GPX5 MAPKAP1 GPX8 PRDX2 GPX7 WIPI1 TFDP1 CTDSP2 PRDX1 TFDP2 PECAM1 CEBPG CACNG7 DNAJB9 FNIP1 FNIP2 TXNRD2 DNAJA4 E2F1 LONP1 E2F3 C12orf66 LIMD1 UBXN7 JUN ATM ITFG2 KPTN MAP4K4 ATR TATDN2 MAPK7 SZT2 CDKN1A PDIA6 CDKN1B PDIA5 DPP3 KLHDC3 DNAJA1-1 BRCA1 SRPRA FLCN RPTOR ATF6B FOS EPAS1 RICTOR ATF4 STAP2 PTPN1 RPA1 PTK6 RPA2 NPLOC4 CDK4 CDK2 UFD1 RPA3 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 MRE11 SESN2 NBN MAPKAPK5 MDM2-2 SLC38A9 ITGAV MAP2K6 PPP1R15A RHEB MDM4 PRR5 MLST8 FKBP4 MTOR RAD50 TRPV4 NRIP1 LY96 SHC1-1 TLR4 UBE2D3;UBE2D2 NFKBIA MAPK1 MAPK3 GRB10 P4HB APOB EP400 CCNA2-1 CCNA1 KDM6B CLOCK GSTP1 RPL12-1 SYVN1 EDEM1-1 DYNC1LI1 DYNC1LI2 NRF1 NPAS2 AKT1S1 SP1 HYOU1 E2F2 PRKAA2 KDR PKN2 DNAJB11 NCF1 NCF2 NCF4 TALDO1 TRIB3 STIP1 COX7B COX7C DNAJA2 COX8A COX8C TLN1 COX5B LMNA COX5A COX6C COX6A1 COX6A2 TXN2 PTK2 COX6B2 COX6B1 NOX4 CALR-1 HIGD1A PGRMC2 CA9 SEC31A DYNC1I1 TGS1 RORA NR3C1 ESR1 VCL NR3C2 AR RXRA CARM1 PGR DCTN1 PPARA TP53 HBA2;HBA1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYBB CYBA JMJD7-PLA2G4B;PLA2G4B CSNK2A2 HMOX1 HMOX2 NR1D1 CSNK2B RPL5-1 BAG4 BAG2 MTF1 TKT ASPIRIN ADME%REACTOME DATABASE ID RELEASE 97%9749641 Aspirin ADME UGT1A1;UGT1A6 GLYATL3 ACSM5 ACSM4 SLC16A1 ACSM2A;ACSM2B GLYAT UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CES2 CES1 CYP2D6;LOC107987479;LOC107987478-1 ALB CYP2C9;CYP2C19 UGT2A1 BSG CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 BCHE ABCC3 ABCC2 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters ARNTL CLOCK CREBBP KMT2A SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655253 Signaling by FGFR2 in disease FGF20 FRS2 NCBP1 GAB1 SOS1 FGF23 PIK3CA FGFR2 FGF2 POLR2E FGF7 POLR2F POLR2H GTF2F1 FGF22 GTF2F2 FGF3 FGF10 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I POLR2J;POLR2J2;POLR2J3 NCBP2-1 PLCG1 HRAS PIK3R1 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 97%2467813 Separation of Sister Chromatids NUP133 NDC80 BUB1 RANGAP1 CLASP2 BUB1B CDC20 PPP1CC BUB3 MAD2L1 SPDL1 NUP43 PSMD12 PSMD11 PSMD14 PSMD13 RANBP2 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 NSL1 RPS27 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 NUP37 PSMC2-1 PSMA2-1 MAPRE1-1 PSMA5 SEM1 PSMA6 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 KNL1 PSMC1 ZW10 CDCA5 PDS5B PDS5A WAPL ESPL1 DSN1 CKAP5 RCC2 ZWINT XPO1 UBA52 AHCTF1 PAFAH1B1 DYNC1I2 PPP2CB;PPP2CA PTTG1;PTTG2 PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C RPS27A PPP2R1B CLASP1 PPP2R5E UBB;UBC DYNC1H1 NDE1 PLK1 DYNC1LI1 DYNC1LI2 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 DYNC1I1 B9D2 SPC24 SPC25 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP KNTC1 CENPA BIRC5 CENPE CENPC SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A CENPT NUP107 CENPU CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPO NUP160 CENPP NUP85 CENPQ ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 CLIP1 MAD1L1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP SEC13 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME%R-HSA-3371497.7 HSP90 chaperone cycle for SHRs ACTR1A DNAJB1 DYNC1LI1 DYNC1LI2 HSPA1L DNAJA1-1 HSP90AA1 PTGES3-1 DYNC1I1 CAPZA3 ACTR10 CAPZB HSPA1A;HSPA1B HSPA2 FKBP5 DNAJA2 NR3C1 DYNC1I2 DCTN2 NR3C2 DCTN6 HSP90AB1 DCTN5 DCTN3 DCTN4 AR PGR DCTN1 HSPA8 DYNC1H1 STIP1 CAPZA1 FKBP4 DNAJA4 CAPZA2 RMTS METHYLATE HISTONE ARGININES%REACTOME DATABASE ID RELEASE 97%3214858 RMTs methylate histone arginines ACTL6A SMARCC1 SMARCC2 H2AJ WDR77 COPRS CCND1 RBBP7 PRMT5 SMARCE1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 JAK2 PRMT6 RPS2 PBRM1 PRMT7 ACTL6B PRMT3 SMARCA2 SMARCA4 WDR5 CDK4 H2AC20 H2AB2;H2AB3;H2AB1 DNMT3A CARM1 H2AZ2;H2AZ1 ARID1A ARID1B H2AC16;H2AC11 H2AC4 SMARCD1 SMARCB1 SMARCD2 ARID2 PRMT1 SMARCD3 H2AC14 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169092 Activation of RAS in B cells RASGRP3 HRAS RASGRP1 NRAS APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.3 Apoptotic cleavage of cell adhesion proteins TJP2 DSP CDH1 CASP3 DSG2 OCLN-1 TJP1 DSG1 PKP1 CTNNB1 DSG3 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.6 DNA Double Strand Break Response ABL1 RBX1 PIAS4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I MDC1 UBE2N KDM4A H2BC21 PSMD12 KDM4B EYA1 KAT5 CHEK2 PSMD11 SMARCA5 PSMD14 PSMD13 SUMO1 PSMA7 PHF6 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 TP53 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 UBE2V2 ADRM1 BARD1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 ATM PSMA3 TP53BP1 PSMC6 PSMA4 RAD50 BAZ1B PSMC3 PSMA1 PSMC4 PSMC1 BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 BABAM1 BABAM2 UIMC1 ABRAXAS1 UBXN1 RNF8 BRCC3 APBB1 H2BC15;H2BC3;H2BC11;H2BC12 EYA2 H2BC5 EYA3 EYA4 BAP1 UBA52 PPP5C H2BC1 DDB1 HERC2 NSD2 RPS27A CUL4A KPNA2 UBB;UBC MRE11 NBN CUL4B MAPK8 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 97%5607763 CLEC7A (Dectin-1) induces NFAT activation AHCYL1 ITPR1 ITPR2 CALM3;CALM1 PPP3CA PPP3CB ITPR3 PPP3R1 NFATC2 NFATC3 NFATC1 INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963678 Intestinal lipid absorption ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.6 Activation of caspases through apoptosome-mediated cleavage APAF1 CASP3 CASP9 CASP7 CYCS-1 XIAP CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 97%5218900 CASP8 activity is inhibited TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FADD TRADD FASLG TRAF2 CASP8 TNFSF10 FAS RIPK1 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 97%69416 Dimerization of procaspase-8 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A FADD TRADD FASLG TRAF2 CASP8 TNFSF10 FAS RIPK1 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418360 Platelet calcium homeostasis SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 P2RX6 ITPR1 P2RX5 ITPR2 P2RX3 STIM1 ITPR3 P2RX2 P2RX1 ORAI2 ORAI1 P2RX7 P2RX4 TRPC7 TRPC6 TRPC3 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 97%9793242 SUMOylation of nuclear envelope proteins SUMO1 RANGAP1 UBE2I GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER RPA1 RPA2 POLD3 POLD4 RPA3 POLD2 RFC5 XRCC1 RPS27A RFC3 LIG1 RFC4 POLE4 RFC2 UBB;UBC POLK POLE POLE2 RFC1 POLE3 POLD1 LIG3 PCNA UBA52 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport ABCG5 ABCC5 ABCC6 ABCC9 ABCA6 DERL3 DERL1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 ABCB7 PSMB6 ABCD1 PSMB7 PSMD6 ABCB4 PSMB4 PSMD7 ERLEC1 PSMB5 ABCB1 PSMB2 PSMB3 PSMD2 PSMD3 ABCA12 PSMB1 PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 APOA1 EIF2S2 EIF2S3;EIF2S3B CFTR KCNJ11 EIF2S1 PEX19 ABCB6 ABCA3 UBA52 ABCA4 ERLIN1 ERLIN2 ABCD2 ABCC10 ABCC4 PEX3 ABCD3 ABCG4 ABCB5 VCP-1 ABCB8 RPS27A ABCB9 DERL2 ABCF1 ABCA2 RNF5 UBB;UBC ABCA5 ABCA9 OS9 ABCA7 ABCA8 ABCB10 ABCG1 RNF185 ABCC3 ABCC1 ABCG8 ABCC2 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry HSPG2 GPC6 FURIN LY96 RAB5B AGRN NCL-1 RAB5C SDC1 CD14 TLR4 RAB5A EGFR GPC1 SDC4 GPC3 SDC2 IGF1R GPC2 SDC3 GPC5 CX3CR1 GPC4 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.4 mRNA decay by 5' to 3' exoribonuclease XRN1 LSM5 LSM4 LSM3 LSM2 DCP2-1 LSM7 LSM6 DDX6 LSM1 PATL1 DCP1A EDC3 EDC4 DCP1B RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 97%9649913 RAS GTPase cycle mutants KRAS HRAS NRAS RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 97%5627123 RHO GTPases activate PAKs FLNA MYL6 PPP1R12B LIMK1 MYH14 PAK1 MYH11 RAC1 NF2 MYH10 PPP1R12A CDC42 PAK3 CALM3;CALM1 MYL12B MYLK CTTN MYH9 PPP1CB PAK2 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias ABCC8 KCNJ11 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 97%3359473 Defective MMADHC causes MMAHCD MMADHC MMACHC CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 97%9664424 Cell recruitment (pro-inflammatory response) C3-1 TXN CTSG HMOX1 NLRP3 HSP90AB1 RELA MEFV NFKB2 PYCARD NT5E P2RX7 PSTPIP1 C3AR1 IL18 CASP1 IL1A IL1B TXNIP P2RX4 SUGT1 NFKB1 GSDMD ENTPD1 ENTPD5 SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA MIGA2 PLA2G4A MIGA1 GPD1L-1 GNPAT PLA2G1B GPD2 AGPAT1 GPD1 AGPAT2 ALPG;ALPP;ALPI-1 AGPAT3 PLA2R1 AGPAT4 GPAT4 GPAT3 GPAT2 PLD6 PLA2G5 PLA2G10;LOC100652777 PLD1 PLA2G2F PLA2G2D PLD2 PLA2G2E DDHD2 DDHD1 GPAM LPCAT4 LPCAT1 LCLAT1 ACP6 AGPAT5-1 PLA2G2A-1 LIPI PLA2G12A LIPH JMJD7-PLA2G4B;PLA2G4B PLA2G4D CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 97%380287 Centrosome maturation CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 TUBG2 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 CDK11A;CDK11B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm MIXL1 SMAD2;SMAD3 FOXA2 CTNNB1 TCF7L2 SMAD4 GATA6 GATA4 CDH1 CXCR4 EOMES TBXT SOX17 GSC METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.3 Metabolism of ingested SeMet, Sec, MeSec into H2Se MAT1A GNMT SCLY NNMT AHCY CBS;CBSL HNMT CTH ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 97%187015 Activation of TRKA receptors ADCYAP1R1 NGF ADORA2A NTRK1 ADCYAP1 NTRK2 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9703009.2 tamatinib-resistant FLT3 mutants FLT3 METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 97%6806664 Metabolism of vitamin K VKORC1 UBIAD1 VKORC1L1 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib CDC37 ERBB2 ERBIN HSP90AA1 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 97%9022699 MECP2 regulates neuronal receptors and channels HDAC1 GPRIN1 MET PTPN1 OPRK1 GRIA2 GRIN2A GRIN2B TRPC3 OPRM1 FKBP5 PTPN4 HDAC2 SIN3A DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 97%5579020 Defective SLC35D1 causes SCHBCKD SLC35D1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol NR1H4 CYP8B1 CYP27A1 RXRA CYP7A1 AKR1D1 CYP7B1 NCOA1 NCOA2 HSD3B7 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 97%192105 Synthesis of bile acids and bile salts NR1H4 CYP8B1 SLC27A2 SLC27A5 CYP46A1 OSBP ACOX2 CYP7B1 HSD3B7 CH25H RXRA AMACR CYP7A1 OSBPL1A OSBPL9 BAAT OSBPL7 CYP39A1 ABCB11 OSBPL6 ABCD3 HSD17B4 OSBPL3 OSBPL2 ACOT8 CYP27A1 AKR1D1 NCOA1 NCOA2 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 97%211736 Stimulation of the cell death response by PAK-2p34 CASP3 PAK2 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 97%1299316 TWIK-releated acid-sensitive K+ channel (TASK) KCNK9 KCNK3 MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.4 Mtb iron assimilation by chelation LTF DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 97%5654687 Downstream signaling of activated FGFR1 FRS2 FGF20 GAB1 SOS1 PIK3CA FGF23 PTPN11 FLRT2 FLRT3 FLRT1 FGF2 FGF22 FGF3 FGF10 PLCG1 HRAS PIK3R1 FGF1 FGF6 FRS3 FGF4 NRAS FGF9 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 97%2243919 Crosslinking of collagen fibrils PXDN LOXL1 LOXL2 BMP1 TLL2 TLL1 PCOLCE LOX LOXL3 LOXL4 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) SOS1 ADRA2C MPL ADRA2A THPO ADRA2B SHC1-1 ITGB3 RASGRP2 CRK RASGRP1 PTK2 FGB AKT1 FGA GP1BB GP1BA FGG F2 RAPGEF3 ITGA2B PTPN1 RAPGEF4 TLN1 VWF PDPK1 BCAR1 SRC FN1 GP5 SYK GP9 RAP1A CSK RAP1B APBB1IP IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-HSA-1855196.3 IP3 and IP4 transport between cytosol and nucleus NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R IGF2 SOS1 HRAS IGF1R IGF1 NRAS SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 97%69239 Synthesis of DNA CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 PSMD13 PRIM2 PRIM1 PSMA7 POLA1 PSMD8 POLA2 PSMB6 DNA2 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 ORC1 PSMA5 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 CDC6 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 PCNA UBA52 CUL1 RPA1 RPA2 CDK2 RPA3 RPS27A UBB;UBC RBX1 POLD1 RFC5 RFC3 RFC4 RFC2 LIG1 POLE RFC1 ANAPC15 ANAPC16 UBE2D1 GINS1 GINS2 ANAPC10 CDC45 ANAPC11 MCM7 MCM8 FZR1 CDC23 POLD3 GINS3 CDC26 GINS4 CDC27 MCM3 POLD4 MCM4 POLD2 ANAPC7 MCM5 MCM6 UBE2C MCM2 POLE4 UBE2E1 FEN1 UBE2S CDC16 CCNE2 ANAPC4 POLE2 CCNE1 ANAPC5 ANAPC1 POLE3 ANAPC2 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 KDM1A AR KLK3;KLK2 H2AC20 KDM4C-1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 NCOA2 H2BC5 PKN1 H2BC1 H2AC14 H2BC21 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH GZMH;GZMB-1 DLL4 NEURL1 HDAC11 CCNC-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP DTX1 HDAC5 HDAC8 DTX2 PSMD12 DTX4 HDAC9 NOTCH1 ST3GAL4 DNER PSMD11 HDAC6 DLK1 PSMD14 CNTN1 HDAC7 PSMD13 SMAD2;SMAD3 RBPJ ST3GAL3 DLL1 H2AC20 PSMA7 PSMD8 H2AB2;H2AB3;H2AB1 LFNG B4GALT1 PSMB6 POGLUT1 PSMB7 MAML2 PSMD6 MAML1 PSMB4 PSMD7 POFUT1 PRKCI PSMB5 TMED2-1 PSMB2 ARRB2 SIRT6 PSMB3 PSMD2 TFDP1 EGF PSMD3 ELF3 TFDP2 PSMB1 PSMD1 MFNG EGFR MAML3 NOTCH2 NOTCH3 ADRM1 NOTCH4 SEL1L PSMC2-1 RFNG E2F1 PSMA2-1 PSMA5 E2F3 ST3GAL6 SEM1 RAB6A PSMA6 JUN PSMC5 SNW1 PSMA3 PSMC6 MAMLD1 PSMA4 MIB2 PSMC3 PSMA1 PSMC4 NCOR2 PSMC1 SKP1 KAT2B H2AJ KAT2A NCOR1 HES5 TLE4 TLE2 TLE1 H2BC5 AKT1 UBA52 H2BC1 STAT1 CUL1 YWHAZ HEYL EP300 RPS27A PSEN2 H2AC4 UBB;UBC APH1A TBL1XR1 APH1B RBX1 FABP7 WWC1 PBX1 CDK8 DLGAP5 PTCRA ACTA2 FCER2 NUMB PSENEN TACC3 HDAC4 MIB1 HEY1 HEY2 JAG1 ADAM10 H2BC21 ADAM17 ITCH JAG2 PSEN1 H2AZ2;H2AZ1 NCSTN TP53 ELANE NEURL1B HIF1A YBX1 MDK MYC HDAC2 HDAC3 HDAC1 HES1 TNRC6C MOV10 TNRC6A-1 HDAC10 AGO4 AGO2 AGO3;AGO1 WWP2 ATP2A3 TNRC6B ATP2A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 ATP2A1 RUNX1 H2BC15;H2BC3;H2BC11;H2BC12 ARRB1 NBEA PLXND1 FURIN FLT4 H2AC14 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 97%190827 Transport of connexins along the secretory pathway GJB2 GJA1 GJB1 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 97%5579032 Defective TBXAS1 causes GHDD TBXAS1 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis NGF RHOA LINGO1 ARHGDIA MAG OMG RTN4 NGFR MCF2 INTERLEUKIN-21 SIGNALING%REACTOME%R-HSA-9020958.3 Interleukin-21 signaling STAT1 IL21 STAT5A STAT3 IL21R STAT5B IL2RG JAK1 STAT4 JAK3 NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373753 Nephrin family interactions PIK3CA WASL ACTN1 SPTAN1 IQGAP1 PIK3R2 PIK3CB ACTN2 KIRREL3 CASK PIK3R1 NCK2 SPTBN1 KIRREL1 FYN KIRREL2 NCK1 ACTN3 MAGI2 ACTN4 CD2AP NPHS1 FORMATION OF THE URETERIC BUD%REACTOME%R-HSA-9830674.1 Formation of the ureteric bud GFRA1 NPNT ITGB1 PAX2 ROBO2 RET GREM1 FOXC2 BMP4 FOXC1 SIX1 GDNF HOXD11 ITGA8 HOXC11 HOXA11 SALL1 WNT11 SIX2 SLIT2 EYA1 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA HADHB-1 HADHA HADH ECHS1 ACADS SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin PCSK1 PLA2G7 CRHR2 IGF1 LEP ACHE MBOAT4 SPCS3 KLF4 INS;INS-IGF2 SPCS2 SPCS1 SEC11A SEC11C BCHE GCG NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation ASB10 FBXL19 FBXL18 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PALB2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 NFE2L2 PSMA1 PSMC4 PSMC1 SKP1 FBXW11 SENP8 UCHL3 UBA52 CUL1 VCP-1 RPS27A UBB;UBC RBX1 SQSTM1 LRRC41 GPS1 CUL3 VHL KBTBD7 DCAF13 FBXO32 DCAF7 FBXO4 FBXO6 FBXW4 FBXW10;CDRT1 FBXW5 FBXW7 MUL1 FBXW9 ELOC-1 FBXW2 ELOB COPS4 COPS2 CISH SOCS2 HIF3A FBXL3 FBXL5 COP1 UBXN7 CDKN1A UBE2D3-1 DPP3 BRCA1 DDB2 LRR1 EPAS1 CCNF KEAP1 SOCS3 NPLOC4 AMER1 UFD1 FBXO7 FBXO9 WSB1 FBXO2 FBXL8 FBXL4 FBXL7 GAN GPR75-ASB3;ASB3-1 KLHL2 KLHL3 KLHL9 SPSB2 SPSB1 KLHL5 KBTBD8 SPSB4 FBXO27 DCAF8 DCAF5 DCAF6 WSB2 DCAF4;DCAF4L2;DCAF4L1 COMMD5;LOC101928879 OBSL1 FBXO21 WDR5 DCUN1D5 FBXO22 DCUN1D3 DCUN1D4 DCUN1D1 COMMD8 FBXW12 COMMD9 KCTD6 PUM2 FBXW8 DDA1 ANKRD9 FBXO17 COMMD2 COMMD3 FBXO15 COMMD1 COMMD6 LMO7 COMMD7 FBXO10 COMMD4 FBXO11 SPSB3 KLHL41 CCDC8 KCTD7 CUL9 BIRC5 KLHL42 UBD HIF1A NAE1 CUL7 SOCS6 CUL5 SOCS5 WDTC1 CCDC22 CUL2 DCUN1D2-1 COMMD10 KLHL11 DTL KLHL13 TULP4 DCAF16 FBXO44 DCAF17 FBXO41 CAND1 FBXO40 FEM1C BTBD1 DCAF10 DCAF11 UBE2F FEM1A RBBP5 FEM1B NEURL2 KLHL25 ERCC8 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 KLHL20 RBBP7 FBXO31 UBA3 UBE2D3;UBE2D2 DDB1 KBTBD13 UBE2D1 COPS7B COPS7A ASB13 ASB14 CUL4A COPS3 COPS6 ASB11 COPS5 RNF7 ASB12 ASB17 COPS8 ASB18 FBXL22 CUL4B ASB15 ASB16 FBXL20 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 97%8849474 PTK6 Activates STAT3 SOCS3 STAP2 STAT3 PTK6 ESSENTIAL FRUCTOSURIA%REACTOME%R-HSA-5657562.5 Essential fructosuria KHK LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 97%9664535 LTC4-CYSLTR mediated IL4 production GGT5 DPEP2 DPEP1 CYSLTR1 CYSLTR2 GGT1 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 97%9918432 Maturation of DENV proteins DPM1 DPM2 DPM3 IPO7 DNAJC10 P4HB SCAP KPNB1 OST4 SEC11A UBE2I RPN2 SEC11C OSTC STT3A RPN1 STT3B SUMO1 DNAJC3-1 DDOST KPNA4-1 DAD1 HYOU1 ACOT2;ACOT1 SPCS3 SPCS2 SPCS1 MAGT1 PRKG2 APOA1 KPNA1 HSPA5 CANX P4HA1 P4HA2 XPO1 P4HA3 DNAJB11 UBA52 CALR-1 KPNA7 KPNA5 RPS27A NMT1 KPNA3 TUSC3 KPNA2 UBB;UBC PDIA3 TMEM258 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%1428517 Aerobic respiration and respiratory electron transport MKLN1 MPC1 MPC2 SURF1 ADHFE1 RMND5B RMND5A SCO1 SCO2 HSCB TMEM126B MPC1L COA3 ACAD9 SFXN4 NUBPL IDH3B IDH3A COA5 PC PDHB SDHAF2 ATP5MC2 ATP5MC3 SDHAF3 IDH3G SDHAF1 ATP5MC1 UBA52 SDHAF4 L2HGDH CYC1 NDUFV3 NDUFV2 ISCA2 NDUFV1 ISCA1 DLST PDK3 RPS27A PDK2 GID4 UQCRFS1 PDK1 GID8 PDHX UBB;UBC NDUFS8 SUCLG2 NEK1 NDUFS7 SUCLG1 NDUFS6 NDUFS4 NDUFS3 NDUFS2 NDUFS1 UQCRB PM20D1 LDHA;LDHC C12orf73 GOT1-1 UQCRQ ACO2 PDPR ETFA ETFB ATP5PF ATP5PD ATP5PB PDP1 PDP2 FXN ATP5PO NDUFA13 SMIM20 NDUFA11 NDUFA12 NDUFA10 CSKMT FOXRED1 ATP5MJ ATP5MG ATP5ME OGDH UQCC3 GSTZ1 UQCC2 SUCLA2 UQCC1 IDH2 TMEM186 TIMM21 BCS1L TMEM177 PYURF DMAC2L TIMMDC1 ETFDH PDK4 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 MAEA NDUFAF1 NDUFS5-1 LDHAL6B COX7B COX7C GLO1 UQCRC1 UQCRC2 COX8A COX8C MRPS36 COX5B COX5A COX6C CS NDUFAB1 ECSIT TACO1 COX6A1 COX6A2 COQ10A-1 SIRT4 SDHC SDHD SDHA COX6B2 SIRT3 SDHB COX6B1 DLD COX19 GOT2-1 FH DMAC2 NDUFB10 COX15 UCP1 NDUFB11 PET117 COX18 COX17 CMC1 CYCS-1 UCP3 UCP2 HIGD1A COX11 COX14 VDAC1 MDH1 PDHA1 MDH2 HIGD2A SMIM4 LETM1 COX20 LYRM2 TMEM223 LYRM4 LYRM7 NDUFC2;NDUFC2-KCTD14 TRAP1 HCCS ACAT1 FAHD1 NNT TTC19 DLAT COX4I1 COX4I2 ME1 ME3 ARMC8 ME2 NDUFC1 SLC25A18 COX7A2L-1 UQCR11 UQCR10 SLC25A12 SLC25A4 ATP5F1A SLC25A11 ATP5F1B LDHB SLC25A14 SLC25A13 LDHA NDUFB9 NDUFB8 NDUFB7 RANBP9 NDUFB6 ATP5F1C NDUFB5 ATP5F1D NDUFB4 NDUFB3 NDUFB2 NDUFB1 OXA1L COX7A2 SLC25A27 HSPA9 D2HGDH GPT TMEM126A-1 SLC25A22 NDUFA9 NDUFA8 NDUFA7 RAB5IF NDUFA6 COQ10B NDUFA4 NDUFA3 WDR26 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia ABCG5 ABCG8 THE IPAF INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844623 The IPAF inflammasome NLRC4 CASP1 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes FKBP14 CXXC1 MYDGF TATDN2 PDIA6 YIF1A PDIA5 HDGF KLHDC3 SRPRA SEC31A GOSR2 SHC1-1 TSPYL2 DDX11 ATP6V0D1 ZBTB17 SSR1 DNAJB11 GSK3A TLN1 DNAJC3-1 EXTL1 ACADVL DCTN1 WFS1 PPP2R5B EXTL2 TPP1 HYOU1 SYVN1 LMNA EDEM1-1 ADD1 WIPI1 CTDSP2 EXTL3 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ARFGAP1 DNAJB9 GFPT1 SRPRB-1 CUL7 JMJD7-PLA2G4B;PLA2G4B PREB KDELR3 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade TBK1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 RIPK3 APP NFKB2 IKBKE RIPK2 JUN PPP2R1A MAPK7 BTRC UBE2D3-1 SKP1 BIRC2 CHUK BIRC3 OPTN-1 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 TANK MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 IRF3 TRAF3 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 NFKBIB SAA2;SAA1 NKIRAS1 TLR3 NKIRAS2 IKBIP TRAF2 TICAM1 CASP8 LRRC14 USP14 RIPK1 NLRC5 TIFA FADD HMGB1-1 UBE2D3;UBE2D2 NFKBIA UBE2D1 RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 97%8963889 Assembly of active LPL and LIPC lipase complexes LPL APOC2 FURIN APOA4 PCSK5 LMF2 MBTPS1 APOA5 LMF1 LIPC CREB3L3 ANGPTL8 PCSK6 ANGPTL3 MBTPS2 FGF21 ANGPTL4 GPIHBP1 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 97%4720454 Defective ALG9 causes CDG-1l ALG9 DISEASES OF BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%9605308 Diseases of Base Excision Repair NEIL3 NEIL1 NTHL1 OGG1 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 97%5690338 Defective ABCC6 causes PXE ABCC6 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669926.2 Nilotinib-resistant KIT mutants KIT PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654720 PI-3K cascade:FGFR4 FRS2 FGF20 GAB1 PIK3CA FGF23 PTPN11 FGF2 KLB FGF19 FGFR4 PIK3R1 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR1C POLR2H POLR1D SSB NFIX NFIA POLR2L NFIB NFIC CRCP SERINE METABOLISM%REACTOME%R-HSA-977347.9 Serine metabolism PHGDH SDSL PSPH SERINC1 SERINC3 SERINC2 SDS SERINC5 SERINC4 SRR PSAT1 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription CDK1 HDAC1 CDT1 CDC6 RBBP4 FBXO5 CCNA1 LIN54 LIN37 DHFR2;DHFR LIN9 LIN52 PCNA TYMS TK1 CDC45 POLA1 E2F4-1 E2F5 E2F6 RRM2-1 TFDP1 RBL2 TFDP2 RBL1 CCNE1 E2F1 ORC1 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation SPINT1 HPN MET SPINT2 HGFAC HGF DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 97%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 97%1839122 Signaling by activated point mutants of FGFR1 FGF20 FGF23 FGFR1 FGF6 FGF1 FGF4 FGF9 FGF2 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1592230 Mitochondrial biogenesis MEF2D APOO APOOL MTERF1-1 HELZ2 TFB1M GABPA MED1 TFB2M PPRC1 MTX2 NRF1 SAMM50 TFAM-1 CHCHD3 CHCHD6 HCFC1 POLRMT POLG2 DNAJC11 TMEM11 TWNK PRKAB2 PERM1 MTX1 PPARGC1A IMMT PPARGC1B SSBP1 TGS1 CREBBP ATF2 RXRA CAMK4 PRKAB1 ALAS1 CARM1 PPARA ESRRA ATP5PF ATP5PD ATP5PB NCOA1 NCOA2 NCOA6 PRKAG2 SMARCD3 HDAC3 ATP5PO ATP5F1A ATP5F1B PRKAA2 CRTC1 PRKAG1 ACSS2 PRKAG3 ATP5F1C NCOR1 NR1D1 ATP5F1D ATP5MJ ATP5MG CALM3;CALM1 ATP5ME ATP5MC2 ATP5MC3 SIRT4 SIRT5 IDH2 ATP5MC1 HSPA9 SIRT3 GLUD1;GLUD2 SOD2 CHD9 CYCS-1 TBL1XR1 MAPK14 MEF2C MAPK11 MAPK12 MICOS13 CRTC2 MICOS10 CRTC3 DMAC2L RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 MUS81 C1orf112 EME1-1 BRCA2 RAD51AP1 DNA2 SLX4 EME2 FIGNL1 GEN1 XRCC2 XRCC3 PALB2 SPIDR BRIP1 SLX1A;SLX1B MRE11 NBN BARD1 RBBP8 SEM1 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids CYP2D6;LOC107987479;LOC107987478-1 CYP2F1 CYP4B1 CYP2A13;CYP2A6;CYP2A7-1 CYP2J2-1 CYP4F22 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2B6 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 97%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell NPDC1 SLAMF6 SIGLEC5;SIGLEC14 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L KLRB1-1 SH2D1A CD19 CD160 ITGB1 CRTAM SH2D1B PILRA;PILRB TREML1 TREM2 SELL TREML4 KLRC4-KLRK1;KLRK1 TREML2 KLRC4;KLRC3;KLRC2;KLRC1 SIGLEC1 B2M TYROBP RAET1E-1 KLRD1 NECTIN2 CD200 CD22 CD40LG CDH1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD33-1 VCAM1 ITGB2 CD3E CD3D CD3G FCGR3A;FCGR3B FCGR1A C3-1 CD300LF;CD300LD ICAM3 ITGAL CD81 ICAM4 ICAM5 TREM1 PVR SIGLEC10;SIGLEC11;SIGLEC16 CD8B;CD8B2 ITGB7 ITGA4 LAIR1;LAIR2-1 CD96 PIANP CXADR SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 LILRA5-4 OSCAR JAML CD8A ULBP1-2 IFITM3;IFITM2;IFITM1 CD300E NCR3LG1-1 CD226 HCST CLEC4G NCR1-1 CD1D CD1C CD1B COLEC12 CD1A LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 SLAMF7 ICAM2 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 CD300LG CD99 ICAM1 KLRG1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function OPN1MW3;OPN1MW2;OPN1MW;OPN1LW PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 97%5576886 Phase 4 - resting membrane potential KCNJ2 KCNK9 KCNJ12;KCNJ18 KCNK3 KCNJ4 KCNK5 KCNK10 KCNK12 KCNJ14 KCNK6 KCNK13 KCNK7 KCNK15 KCNK16 KCNK1 KCNK18-1 KCNK17 KCNK2 KCNK4 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency HLCS MCCC1 PCCB ACACA MCCC2 PC PCCA DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918449 Defective visual phototransduction due to STRA6 loss of function TTR STRA6 RBP4 FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles FMO1 FMO2 FMO3 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly IPO5 HSP90AA1 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6PC1 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange RAD17 ATM RAD50 ATR BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN RAD9B KAT5 CHEK1 RAD51B RAD9A RAD51C RPA1 HUS1 RPA2 EXO1 BRCA2 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 XRCC2 RFC2 BRIP1 MRE11 ATRIP NBN BARD1 RBBP8 SEM1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type PTGIS NR1H4 CYP26B1 CYP27B1 CYP26A1 AHR CYP24A1 CYP2S1 CYP7B1 CYP19A1 POMC TBXAS1 FDXR RXRA CYP1B1 CYP7A1 CYP4F22 CYP11B1;CYP11B2 CYP2C18-1 CYP2J2-1 ARNT NCOA1 NCOA2 FDX1 CYP2B6 CYP2W1 CYP8B1 ARNT2 CYP46A1 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP4B1 CYP21A2 CYP1A1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP51A1 CYP2E1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP11A1 CYP39A1 AHRR CYP27A1 CYP2F1 CYP2R1 CYP2A13;CYP2A6;CYP2A7-1 CYP4V2 POR CYP2U1 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662360 Sensory processing of sound by inner hair cells of the cochlea KCNMB1 STX1A KCNMA1 CAPZB CACNB2 MYH9 CACNA2D2 SNAP25 EPB41L1 SLC17A8 CAPZA1 RIPOR2 CLIC5 CAPZA2 CIB2 PJVK EPS8 PCLO BSN TPRN PLS1 TMC1 ESPN-1 MYO7A SYP TMC2 MYO3B DNAJC5 MYO3A KCNQ4 FSCN2 MYO1C EZR PCDH15 USH1C ATP2B1 CABP2 TWF1 CABP1 LRRC52 ESPNL CDH23 CASK OTOF SPTBN1 XIRP2 EPS8L2 GRXCR1 GRXCR2 WHRN RDX RAB3A LHFPL5 VAMP2 MSN TMIE USH1G STRC SYN1 MYO15A SPTAN1 CACNA1D GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 97%9726842 Gain-of-function MRAS complexes activate RAF signaling ARAF MRAS RAF1 YWHAB BRAF SHOC2 PPP1CB PPP1CC BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 97%2142700 Biosynthesis of Lipoxins (LX) ALOX12 HPGD ALOX5AP ALOX5 LTC4S PTGR1-1 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism PDK4 LDHB MKLN1 LDHA RANBP9 PC LDHA;LDHC MPC1 PDHB MPC2 MAEA GSTZ1 LDHAL6B RMND5B RMND5A SIRT4 GLO1 UBA52 FAHD1 GPT DLD MPC1L DLAT PDPR PDK3 RPS27A WDR26 PDK2 GID4 PDK1 GID8 UBB;UBC PDHX ME1 ME3 ME2 ARMC8 VDAC1 PDHA1 NEK1 PDP1 PDP2 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME DATABASE ID RELEASE 97%4043911 Defective PMM2 causes CDG-1a PMM2 CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.14 Carbohydrate metabolism PPP1R3C DCXR ABCC5 HKDC1 PXYLP1 LALBA B4GALT6 B4GALT7 B4GALT4 B4GALT5 NDST2 NDST1 SLC26A11 CSGALNACT1 NDST4 NDST3 PRELP CSGALNACT2 SDC4 KERA PGD B3GAT3 SDC2 B3GAT2 PHKA1 SDC3 RPE;RPEL1 B3GAT1 PHKA2 SLC26A2 ST3GAL4 SLC26A1 GNPDA1 GNPDA2 ST3GAL1 AKR1B1 HMMR ST3GAL2 ST3GAL3 HYAL2 SDC1 PHKB AKR1A1 ADPGK PRKACA-1 PPP2R1A CHPF2 CHST6 CHST7 BPGM PC PGM2L1 G6PD GPC1 FUT2 FUT1 GPC3 FUT4 GPC2 CHST1 GPC5 FUT7 FUT9 UBA52 GPC4 NUP214 SLC35B3 CHST2 GPC6 SLC35B2 CHST3 HS6ST1 HS6ST2 HS6ST3 AGRN RPS27A GAPDH-1 UBB;UBC HS3ST3B1 SLC35D2 DERA TKFC RPIA PGK1 GBE1 PRKACB-1 G6PC1 G6PC2 ENO1 G6PC3 ENO2 ENO3 OGN HSPG2 BCAN ENO4 HPSE B4GAT1 PGM2 PGLS GLCE PGM1 NHLRC1 CHST11 PRPS2 NUP107 CHST12 PRPS1 NUP188 CHST15 CHST13 CHST14 CTSV;CTSL NUP210 PHKG1 PHKG2 CALM3;CALM1 NUP93 DCN NUP205 AAAS NUP160 NUP85 CD44 TPR NUP88 NUP155 GALM-2 OMD TALDO1 NUP153 ACAN CRYL1 HK2 HK1 HS2ST1 HK3 NUP62 PCK1 GAPDHS B4GALNT2 ALDH1A1 PCK2 RBKS NDC1 SEC13 NUP133 EXT1 UGP2 EXT2 CHSY3 NUP50 POM121;POM121C FMOD LUM NUP54 CHSY1-1 UXS1 CHPF NAGLU XYLB CHP1 GYG2 GYG1 NUP42 CEMIP KHK NUP43 RAE1 RANBP2 GAA HS3ST3A1 AGL-1 GALE B4GALT1 SLC37A1 NUP35 NUP37 IDUA HEXB NCAN HEXA SLC37A4 BGN ST3GAL6 GLB1L3 GLB1L2 VCAN GLB1L SORD GLB1 HYAL1 HYAL3 HYAL4 IDS CSPG5 GUSB ARSB B3GALT2 B3GALT1 PFKL PGAM1 PGAM2 PFKM PFKP HPSE2 SHPK PPP2CB;PPP2CA EXTL2 PPP2R5D HAS1 PPP2R1B HAS3 HAS2 EXTL3 GALK1 EPM2A FBP1 FBP2 GALT PFKFB2 PFKFB1 PFKFB4 STAB2 PFKFB3 GYS2 GYS1 SLC9A1 DSEL HS3ST5 HS3ST6 HS3ST4 HS3ST1 B3GALT4 HS3ST2 B3GALT6 MANBA B3GALT5 GALNS UST XYLT2 B3GNT7 XYLT1 B3GNT4 FAM20B DSE B3GNT3 B3GNT2 ALDOC ALDOB ALDOA SPAM1 GNS ST6GALNAC6 LYVE1 FUT6;FUT5;FUT3 PYGB GPI PYGM PYGL GCKR GCK MAN2B2 TPI1 MAN2B1 B4GALT2 B4GALT3 TKT SLC2A1 SGSH PAPSS2 PAPSS1 SLC17A5 MAN2C1 GLYCTK DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants PDGFRA ERROR-RONE BASE EXCISION REPAIR (BER) HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME DATABASE ID RELEASE 97%9968297 Error-rone base excision repair (BER) hypermutates immunoglobulin genes POLH POLD3 POLD2 RFC5 RPS27A RFC3 RFC4 APEX2 RFC2 UBB;UBC REV1 RFC1 MAD2L2 REV3L PCNA UBA52 POLI TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME DATABASE ID RELEASE 97%1362277 Transcription of E2F targets under negative control by DREAM complex HDAC1 CDC6 CDC25A TOP2A RBBP4 MAX E2F4-1 E2F5 TFDP1 RBL2 TFDP2 RBL1 LIN54 LIN37 LIN9 LIN52 MYC PCNA E2F1 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 97%3359475 Defective MMAA causes MMA, cblA type MMAA MMUT QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702620.2 quizartinib-resistant FLT3 mutants FLT3 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) GLB1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D GNS CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.4 Cysteine formation from homocysteine CBS;CBSL CTH GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 BTRC RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 GSK3B UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 CD274 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 COPS5 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation LTF PRKN B2M PSENEN INS;INS-IGF2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PRL CALB1 BACE1 MFGE8 H2BC21 NPPA ADAM10 IAPP APCS HSPG2 CALCA TSPAN33 CST3 TSPAN5 SNCA APP ODAM NAT8-2 SNCAIP H2AC20 SORL1 TSPAN15 H2AB2;H2AB3;H2AB1 TSPAN14 H2AZ2;H2AZ1 TGFBI ITM2B NCSTN GGA2 GGA1 GGA3 SAA2;SAA1 USP9X APOA1 APOA4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 UBE2L6 TTR H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 FGA UBA52 H2BC1 FURIN LYZ-1 RPS27A H2AC4 UBB;UBC APH1A GSN APH1B APOE SIAH2 SIAH1 H2AC14 LDL REMODELING%REACTOME DATABASE ID RELEASE 97%8964041 LDL remodeling CETP MTTP P4HB APOB APOF FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME%R-HSA-9706374.2 FLT3 signaling through SRC family kinases SYK FLT3LG HCK LCK FYN FLT3 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 97%110314 Recognition of DNA damage by PCNA-containing replication complex DTL RBX1 UBE2B RAD18 POLE RFC1 POLD1 PCNA UBA52 DDB1 RPA1 RPA2 POLD3 POLD4 POLD2 RPA3 USP1 RPS27A RFC5 RFC3 RFC4 POLE4 CUL4A UBB;UBC RFC2 POLE2 POLE3 CUL4B WDR48 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.5 APC C:Cdc20 mediated degradation of mitotic proteins CDK1 BUB1B CDC20 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CCNB1 ANAPC11 PTTG1;PTTG2 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 97%8948216 Collagen chain trimerization COL6A2 COL4A3 COL6A1 COL8A2 COL4A6 COL21A1 COL8A1 COL6A3 COL6A6 COL4A5 COL6A5 COL16A1 COL12A1 COL25A1 COL11A1 COL11A2 COL28A1 COL1A1 COL24A1 COL1A2 COL22A1 COL3A1 COL5A1 COL5A3 COL7A1 COL23A1 COL5A2 COL20A1 COL15A1 COL17A1 COL19A1 COL13A1 COL26A1 COL10A1 COL9A1 COL27A1 COL9A3 COL9A2 COL18A1 COL14A1 COL2A1 COL4A2 COL4A1 COL4A4 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 97%499943 Interconversion of nucleotide di- and triphosphates TXN CTPS2 CTPS1 NME4-1 GLRX AK4-1 TXNRD1 DCTD CMPK1 DTYMK AK1 RRM1 AK2 GUK1 TYMS AK5 AK6 AK7 NME2 AK8 AK9 NME3 NME1 NME6 RRM2-1 RRM2B NUDT13 DCTPP1 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling SOS1 MET MUC20 HRAS RANBP9 NRAS RANBP10 HGF TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest CDK1 SFN AURKA BAX CCNB1 CARM1 EP300 ZNF385A E2F4-1 TP53 TFDP1 RBL2 TFDP2 RBL1 PRMT1 PCNA GADD45A CDC25C IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112399 IRS-mediated signalling FGF20 FRS2 GAB1 SOS1 FGF23 FLT3LG PIK3CA PTPN11 AKT2 GAB2 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 FGF10 FGF19 FGFR4 IRS2 FLT3 PIK3R4 THEM4 PDPK1 TRIB3 IRS1 PIK3C3 PIK3R2 PIK3CB HRAS PIK3R1 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 NICOTINATE METABOLISM%REACTOME DATABASE ID RELEASE 97%196807 Nicotinate metabolism NUDT12 NMNAT3 PARP9 NMNAT2 BST1 QPRT PARP8 NMNAT1 NADK NAXE SLC22A13 SLC25A51;SLC25A52 SLC5A8 NMRK2 NMRK1 NNMT NADSYN1 PARP16 PARP14 NT5E CD38 PARP10 NAXD NADK2 NAMPT NAPRT PARP6 PARP4 RNLS LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 97%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions PARVA ITGB1 PXN ILK CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 97%1500931 Cell-Cell communication PTK2B CSNK2A1;CSNK2A3 NECTIN2 MOGS RPN2 RPN1 PSMD12 PSMD11 PSMD14 PSMD13 WASL PSMA7 PSMD8 PSMB6 PSMB7 ITGB4 PSMD6 PSMB4 PSMD7 ILK PARVA PSMB5 TESK1 PSMB2 CLDN2 PIP5K1C PSMB3 PSMD2 ZC3H12A PCSK7 PSMD3 ANK3 CLDN6 CLDN4 PSMB1 PSMD1 CLDN3 CLDN9 CLDN8 JAK1 CLDN7 ADRM1 RSU1 CADM3 PSMC2-1 CADM1 CADM2 PSMA2-1 PARVB PSMA5 XIAP CLDN23-1 SEM1 LIMS4;LIMS1 PSMA6 CLDN20 PSMC5 TYK2 CLDN11 PSMA3 CLDN10 PSMC6 CTNND1 MTBP PSMA4 CLDN15 RACK1 CLDN14 DST CBLL1 CLDN12 PSMC3 PSMA1 CLDN19 EPS15 CLDN18 PSMC4 CLDN17 PSMC1 ITGA6 CD47 CTNNB1 BIRC2 CLDN16 FLNC ADAM33 PLEC CANX LIMS2 CD151 CDH9 CDH8 PCSK6 CDH7 CDH6 CDH3 TLE1 SKAP2-2 ADAM19 FBLIM1 SIRPA;SIRPB1;SIRPG CDH24 SDK1 SDK2 SIRPB1 CLDN22;CLDN24-1 CDH10 UBA52 CDH12 CDH13 CDH17 CDH18 KDM1A CDH19 PARD6G NECTIN4 MPP5 NECTIN3 NECTIN1 RPS27A CRB3 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 STAT3 SNAI1 CLDN5 SNAI2 TYROBP CDH1 JUP OST4 OSTC FERMT2 STT3A ANG JAK2 SP1 PRKCSH COL17A1 F11R DDOST PARD3 DAD1 CDC42 IL6ST FYN LAMC2 GANAB CTSS FLNA PTPN11 FARP2 CTSB CTSV;CTSL ACTN2 CASK IL6R LAMA3 FURIN LAMB3 CDH4 CTBP2 CDH2 CTBP1 RB1 CDH15 H2AC14 NCK2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A NCK1 SEC11C SMARCA4 FOXA2 CDH5 H2AC20 H2AB2;H2AB3;H2AB1 SRC EZH2 TGIF2 PARD6B PARD6A PRKCI IQGAP1 SPCS3 SPCS2 SPCS1 BANP SIRT1 ACTN1 RAC1 H2AJ TCF12 CLDN1 ANGPTL4 ELMO1 SPTBN1 DOCK1 SUZ12 PTK2 H2BC5 H2BC1 PXN SOX10 DNM2 MPHOSPH8 SPTAN1 HEYL PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 H2AC4 VAV2 HACE1 KMT5A ARHGEF4 ARHGEF6 ITGB1 MDM2-2 CTNNA1 KLF4 STRAP KIRREL3 KIRREL1 KIRREL2 ACTN3 TWIST2 MAGI2 ACTN4 CD2AP NPHS1 H2BC21 VCL RNF19B VASP EED FYB1 WT1 H2AZ2;H2AZ1 ARID1A PIK3R2 PIK3CB PIK3R1 MYC HDAC2 MYCN HDAC1 PIK3CA PTPN6 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 CDH11 AGO3;AGO1 ZNF217 TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 TIAM1 PVR RELA TRAF7 ZMYM2 NFKB1 IL6 MAPK1 POMT2 MAPK3 PATJ POMT1 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 97%9662001 Defective factor VIII causes hemophilia A TPST2 F2 TPST1 F8 F9 VWF F10 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3781860 Diseases associated with N-glycosylation of proteins MGAT2 GLB1 ALG8 ALG9 B4GALT1 ALG6 ALG2 ALG3 ALG1 RFT1 MAN1B1 CTSA MOGS MPDU1 NEU1 DPAGT1 ALG14 ALG12 ALG11 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 97%5625970 RHO GTPases activate KTN1 RHOG RHOA KIF5B KLC1 KIF5A KLC4 KLC3 KLC2 RAC1 KTN1 CDC42 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 97%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 97%9709570 Impaired BRCA2 binding to RAD51 RAD17 ATM RAD50 ATR BLM BRCA1 RMI2 RAD51 RMI1 TOP3A WRN RAD9B KAT5 RAD9A RPA1 HUS1 RPA2 EXO1 BRCA2 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 RFC2 BRIP1 MRE11 ATRIP NBN BARD1 RBBP8 SEM1 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%192814 vRNA Synthesis PARP1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620922 BBSome-mediated cargo-targeting to cilium TTC8 BBS7 BBS5 BBS4 MKKS LZTFL1 ARL6 SMO CCT3 SSTR3 MCHR1 BBS10 CCT2 BBS12 CCT8 CCT5 CCT4 BBS2 BBS1 RAB3IP BBIP1 TCP1 BBS9 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 97%5663213 RHO GTPases Activate WASPs and WAVEs ABL1 ARPC4 ARPC5 WAS NCKIPSD ARPC2 ARPC3 RAC1 BTK ACTB-1 ABI2 NCKAP1L ABI1 NCK1 ACTR2 PTK2 ARPC1B ARPC1A ACTR3-1 WASL CYFIP2 CYFIP1 NCKAP1 ACTG1 WASF1-1 CDC42 WIPF1 WIPF2 WIPF3 MAPK1 WASF2 MAPK3 WASF3 BAIAP2 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 97%9610379 HCMV Late Events NUP133 VPS37C VPS37D VPS37A VPS37B NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CEBPD VPS4A H2BC18 NUP42 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MVB12B MVB12A NUP43 H2BC21 RAE1 RANBP2 H2AC20 CHMP1A UBAP1 NUP35 NUP37 VPS36 SNF8 VPS25 NUP107 NUP188 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP210 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 TSG101 H2BC15;H2BC3;H2BC11;H2BC12 AAAS H2BC5 NUP160 NUP85 H2BC1 NUP214 TPR NUP88 NUP155 NUP153 CHMP2B CHMP2A H2AC16;H2AC11 H2AC4 NUP62 HNRNPK NDC1 H2AC14 SEC13 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4615885 SUMOylation of DNA replication proteins NUP133 TOP2A TOP2B NUP107 NUP188 RANGAP1 NUP50 POM121;POM121C CDCA8 NUP54 TOP1 NUP210 NUP93 PIAS4 PIAS3 NUP205 NUP42 UBE2I AAAS PCNA NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 AURKA SUMO1 SUMO3 SUMO2 NUP153 INCENP NUP35 NUP62 BIRC5 NUP37 AURKB NDC1 SEC13 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD GCLC GCLM CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis ISL1 CTNNB1 FOXO4 KAT2A HEY1 HEY2 KAT5 LEF1 WDR5 MESP1 TBX20 HAND2 LDB1 SMYD1 TBX1 SRF MYOCD HAND1 SMAD1 SMAD4 GATA6 TBX5 GATA4 MEF2C NKX2-5 EOMES TBXT TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades S100A8 TLR2 TBK1 APOB DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 ITGB2 SOCS1 PIK3R4 RIPK3 APP NFKB2 GSDME TLR6 TLR5 LGMN IKBKE CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC UBE2D3-1 SKP1 ECSIT BIRC2 CHUK BIRC3 BTK OPTN-1 TLR8 TLR7 FBXW11 IKBKB IKBKG FOS UBA52 DNM1 DNM2 CUL1 DNM3 TANK MAPKAPK2 LBP TLR10 PPP2CB;PPP2CA CD180 PPP2R5D ATF1 LY86 RPS27A ELK1 ITGAM RPS6KA3 PPP2R1B S100A1 EEA1 RPS6KA5 TASL RPS6KA2 IRF5 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 GSDMD MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 HSP90B1 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 RBSN IRF3 TRAF3 TRAF6 IRF7 TP53 PIK3C3 NOD1 NOD2 CTSS ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 CTSK PTPN11 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 TLR3 NKIRAS2 LY96 IKBIP IRAK4 PLCG2 TRAF2 PELI1 TICAM1 TLR9 CASP8 CTSB LRRC14 CTSV;CTSL USP14 PELI3 RIPK1 PELI2 NLRC5 CD14 TIFA FADD HMGB1-1 TLR4 MAP3K1 CNPY3 SIGIRR IRAK3 FGB UBE2D3;UBE2D2 NFKBIA FGA FGG UNC93B1 UBE2D1 RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 SLC15A4 PTPN4 TLR1 BPI S100A9 DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 97%4724325 Defective ALG8 causes CDG-1h ALG8 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME%R-HSA-5579013.4 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation POLRMT TFB2M TFAM-1 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons GJB2 GJA1 GJB1 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 97%69002 DNA Replication Pre-Initiation H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PSMD12 PSMD11 PSMD14 PSMD13 PRIM2 PRIM1 H2AC20 PSMA7 POLA1 PSMD8 POLA2 H2AB2;H2AB3;H2AB1 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 ORC1 CDC7 PSMA5 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 CDC6 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 H2AJ H2BC5 UBA52 H2BC1 RPA1 RPA2 CDK2 RPA3 RPS27A H2AC4 UBB;UBC KPNA6 MCM10 DBF4 KPNB1 H2BC21 H2AZ2;H2AZ1 KPNA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLE H2BC15;H2BC3;H2BC11;H2BC12 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CDC45 ANAPC11 MCM7 MCM8 FZR1 CDC23 CDC26 CDC27 MCM3 MCM4 ANAPC7 MCM5 MCM6 UBE2C MCM2 POLE4 UBE2E1 UBE2S CDC16 ANAPC4 POLE2 ANAPC5 ANAPC1 POLE3 ANAPC2 H2AC14 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 97%3371571 HSF1-dependent transactivation HSP90AB1 DNAJB1 CAMK2G MTOR HSPA1L HSBP1 HSF1 MLST8 HSP90AA1 RPTOR EP300 PTGES3-1 HSPA8 HSPB8 AKT1S1 HSPA1A;HSPA1B HSPA2 CAMK2B CREBBP FKBP4 CAMK2D CAMK2A CRYAB TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 97%9694635 Translation of Structural Proteins FUT8 MAN2A1 GSK3B ST6GAL1 MOGS OST4 UBE2I RPN2 OSTC STT3A RPN1 CSNK1A1 STT3B GSK3A ST3GAL4 ST6GALNAC2 PRKCSH ST3GAL1 MGAT4A-1 ST3GAL2 ST3GAL3 SUMO1 SRPK2 EDEM2 PARP16 DDOST PARP14 SRPK1 PARP10 DAD1 MAN1B1 ST6GALNAC3 ST6GALNAC4 MAGT1 PARP6 PARP4 GANAB PRMT1 GALNT1 PARP9 MGAT4C MGAT4B PARP8 CANX ZDHHC20 MGAT5 MGAT1 UBA52 MGAT2 ZDHHC9 RPS27A TUSC3 UBB;UBC ZDHHC5 ZDHHC8 ZDHHC2 GOLGA7-1 ZDHHC3 TMEM258 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 EPO STAT5A EPOR STAT5B IRS2 JAK2 LYN REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome RB1 DDX5 ZCRB1 VHL SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853333 Signaling by FGFR2 fusions FGFR2 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose NR1H3 RXRA PLIN1 RXRB NR1H2 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 SIGNALING BY MAP2K MUTANTS%REACTOME DATABASE ID RELEASE 97%9652169 Signaling by MAP2K mutants MAP2K2;MAP2K1 MAPK1 MAPK3 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 97%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine PNP-1 CHD1 AND CHD2 SUBFAMILY%REACTOME%R-HSA-9943411.1 CHD1 and CHD2 subfamily TCF4 PHF5A SNRPF SNRPD2 SNRPD1 SNRPN SNRPB CTR9 SNRPD3 RTF1 MYOG PAF1 DHX15 MYOD1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC21 SNRPE-2 DDX46 DDX42 RBM17 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 SSRP1 SMNDC1 U2SURP SNRPG-2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 H2AJ SF3A3 SF3A1 CDC73 SUPT16H TCF12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SF3A2 LEO1 CHERP SF3B1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 PUF60 SNRPB2 SNRPA1 H2AC4 WDR61 CHD2 H2AC14 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives ALOX12 GPX4 ALOXE3 ALOX12B GPX1 ALOX15 IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 97%917937 Iron uptake and transport ATP6V0B TF ATP6V1B2 ATP6V0C ATP6V1B1 ATP6V1G3 LCN2 ACO1 ATP6V0E2;ATP6V0E1 FBXL5 MCOLN1 CAND1 ATP6V1E1 ATP6V1E2 ATP6V1G1 SLC40A1 ATP6V1G2 HMOX1 HEPH SKP1 HMOX2 ATP6V1H ATP6V0D1 ATP6V0D2 ABCG2 ATP6V1A SLC46A1 UBA52 ATP6V0A2 FTH1 ATP6V0A4 CP CUL1 ATP6V1D ATP6V1C1 ATP6V1F SLC11A2 ATP6V0A1 ATP6V1C2 ATP6AP1 RPS27A TFRC UBB;UBC STEAP3 STEAP4 HFE TCIRG1 SLC22A17 GLRX3 TFR2 FTL-1 IREB2 FTMT CYBRD1 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 97%5624138 Trafficking of myristoylated proteins to the cilium CYS1 UNC119B ARL3 RP2 NPHP3 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors KDM5B CDKN1A TFAP2A TFAP2C MYC TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 97%933542 TRAF6 mediated NF-kB activation S100A12 NFKBIB APP SAA2;SAA1 RELA NKIRAS1 NKIRAS2 NFKB2 TRAF2 CHUK DDX58 TRAF6 NFKB1 HMGB1-1 MAP3K1 RNF135 IFIH1 IKBKB TRIM25 MAVS IKBKG NFKBIA AGER CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 97%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A CDK1 BUB1B CDC20 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013406 RHOQ GTPase cycle GJA1 ARHGEF7 SRGAP2 RHOQ STOM PAK1 IQGAP3 SLC4A7 SNAP23 PAK4 GIT2 JUP CAV1 PLEKHG3 MPP7 DLC1 TRIP10 ARHGAP1 WASL CDC42EP4 SYDE1 CDC42EP3 CDC42 CDC42EP2 IQGAP1 CDC42EP1 ARL13B VAMP3 ARHGAP5 CDC42BPB ARHGAP21 CDC42BPA CPNE8 ARHGAP17 OPHN1 ARHGAP35 SCRIB WWP2 CFTR VANGL1 DEPDC1B RAB7A ARHGAP26 ARHGAP33 GOPC ARHGAP32 PAK2 DIAPH3 GIT1 TFRC LAMTOR1 ITSN1 STEAP3 PREX1 SLC1A5 FNBP1 RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription CSNK2A1;CSNK2A3 HDAC11 BMI1 YY1 RING1 MAF HDAC5 HDAC9 RNF2 HDAC6 HDAC7 CBX8 GPAM CBX6 PHC2 PHC1 POU2F1 CBX4 CBX2 NFATC2 POU2F2 PHC3 NFYA-1 ERBB2 EGFR YWHAE PRKACA-1 LBR PPP2R1A YWHAG SKP1 TCF7 CDC73 LEO1 UBA52 CUL1 AURKA CCNB1 RPS27A UBB;UBC MEF2C CENPJ SPI1 TGIF1-1 CDK1 ZNF287 ZNF18 RBFOX1 RBFOX3 BCL2L11 TXN ZNF282 ZNF10 ZNF12 CLDN5 PMAIP1 DDIT3 ZNF23 BID ZNF25 BBC3 GRIN2A ZNF268 ZNF263 ABCA6 NR2F1 NR0B2 GRIN2B NR2F6 COL1A1 INS;INS-IGF2 COL1A2 ZNF496 ZNF250 UCMA ZNF45 HEY1 HEY2 ZNF41 CTLA4 ZNF248 ZNF485 ZNF483 ZNF235 SLBP ZNF473 SERPINB13 ZNF470 HTT ZNF226 ZNF222 CR1L;CR1 ATAD2 ZNF77 ZNF79 SKI ZNF70 AGRP ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZKSCAN4;ZKSCAN3 ZNF692 ZNF691 NFYB RORC RORB NFYC ZNF689 ZNF205 ZNF446 ZNF688 ZNF445 PITX2 ZNF202 ZNF200 ZNF160;ZNF347;ZNF665-1 ZFP69B CTSK FOXP3 NPAS4 ZNF432 PVALB BLK GRIA2 MAX DLX6 FOXO4 FOXO3 CTSV;CTSL ATXN3 ZKSCAN8 ZNF668 ZNF667 ZKSCAN5 ZNF664 SOCS4 ZKSCAN1 ZNF662 ZNF660 FBXO32 ZNF419 MMP13 ZNF658 ZNF416 ZNF655 SP7 ITGAL DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 ITGA4 TNFRSF18 FURIN ZKSCAN7;ZNF852 PPM1A HAND2 ITGA5 SPP1 PPM1D YAP1-1 ZNF624 ZNF621 E2F5 E2F6 ZNF747;ZNF764 MGA TBX5 PINK1 SST SYT10 IL2RA ZNF615 ZNF614 RB1 ZNF613 SMARCB1 STUB1 CCNH EHMT2 PTPN4 EHMT1 TRIM33 UXT LGALS3 CCN2 H2AC14 TRIM28 ZFP1 ZNF713 ZNF711 ZNF710 L3MBTL2 FOXG1 TGFA ZNF707 MED1 ZNF706 SMARCC1 ZNF704 SMARCC2 ZNF703 HIVEP3 WWTR1 YES1 MED4 IQSEC3 MED6 ITGBL1 MED7 MSTN HNF4G FOXO1-1 SATB2 ZFP14 RXRG ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 GAD1 GAD2 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A CCNG2 PPARGC1B ZFP28 CREBBP IHH ZNF274;ZNF74 ZNF382 CCND3 CCND2 NPPA SETD1B MSX2 SETD1A GEM SMARCA2 GPRIN1 SMAD2;SMAD3 SMARCA4 ZFHX3 AUTS2 IL2 IL3 H2AC20 ZNF30 BMP2 LDB1 H2AB2;H2AB3;H2AB1 MYBL2 EZH2 RBM14 CBX3-1 TGIF2 ELF1 PHF20 ELF2 CAT RETN ASH2L ZNF804B MED16 ZNF175 MED17 SERPINE1 MED12 JUNB MED14 RNF111 MED13 ZSCAN25 MED10 ZNF157 ZNF398 ZNF394 NKX2-5 NR2C2AP ZNF383 ZNF140 CDC7 NR1D2 ACTL6A ZNF699-7 ZNF135 ZNF133 RARG MED27 BTG1 ZNF568-3 SIRT1 UBE2D3-1 MED23 RSPO3 TEAD1 TEAD2 NCOR2 TEAD3 KAT2B ZIK1 H2AJ TEAD4 KAT2A TCF12 PAX5 NCOR1 MED24 TAL1 RARB ZNF599 ZNF114 MED20 ZNF597 ZNF112 OCLN-1 ZIM2 ZNF584 GPS2 ZNF583 PCGF6 MBD3 ZNF582 CDKN2B SUZ12 H2BC5 PCGF5 PCGF2 WWP1 SIRT3 H2BC1 RYBP ZNF669;ZNF670 ZNF334 GTF2H1 ZNF573 GTF2H3 ZNF570 GTF2H4 CSF2 GATAD2B ITGA2B GATAD2A ZFP30 ZNF569 ZNF567 MED31-1 ZNF566 ZFP37 ZNF331 ZNF565 CYCS-1 ZNF563 IGFBP1 EP300 PF4;PF4V1-1 ZNF302;ZNF181 NRBP1 MEN1 ZNF311 ZNF793 ZNF792 H2AC4 ZNF791 KRBA1 ZNF549 ZNF548 TBL1XR1 ZNF317 ZNF546 ZNF354A;ZNF354B-4 ZNF304 ZNF786 KMT2D SKIL PLXNA4 KMT2A ZNF300 KMT2C ZNF782 KMT2B ESRRB ESRRG ZFP69 MED30 CDK6 ZNF777 ABL1 ZNF775 ZNF426-1 ZNF774 ZNF772 ZNF324B;ZNF324 ZNF771 ZNF770 ZNF529 ZNF521 CBX5 CDK8 ZNF75D CDK7 ZNF75A STK11 CDK5 ZFP90 CRH ZNF514 ZNF750 MNAT1 ZNF746 ZNF740 GSK3B KCNIP3 KLF4 RAD51 ZNF606 DPY30 ZNF605 CHD4 SOX9 CHD3 ZNF839 ZNF555;ZNF57;ZNF556 TWIST2 CITED1 SIN3B CITED2 SIN3A CITED4 H2BC21 PARP1 GP1BA ZNF649 ZNF3 ZNF350;ZNF432 ZNF557;ZNF558 NPY WDR5 CAMK4 LMO1 ZNF197;ZNF660-ZNF197 TBP LMO2 EED ATP1B4 LIFR KCTD6 H2AZ2;H2AZ1 ZNF124-4 ARID1A COX4I1 NOP2 ARID1B COX4I2 ZNF264;ZNF805-1 SMAD1 SMAD4 SMURF2 SMURF1 SMAD6 ESR2 SMAD7 NR4A1 NR4A3 THRA ARNT SMARCD1 NR2E1 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 OPRM1 SMARCD2 CAMK2B CAMK2D HDAC2 CAMK2A SMARCD3 NR2C2 HDAC3 THBS1 HSPD1 HDAC1 HES1 CAMK2G ZNF189 ZNF286A ZNF184 ZNF180 RBBP4 OPRK1 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 MTA2 POLR2L SMARCE1 DEK H2BC15;H2BC3;H2BC11;H2BC12 ERCC3 ERCC2 NDUFA4 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RXRB ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 G6PD YWHAB XPO1 AKT1 YWHAZ MAPK14 MAPK11 GLI3 GLI2 RBX1 ITCH PIP4K2A PIP4K2B PIP4K2C MED8 CCNK CCNT1 GTF2B SUPT16H GTF2F1 GTF2F2 NEDD4L GTF2E1 GTF2E2 PIP4P1 SUPT4H1-1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B RRM2-1 ELL ELOC-1 TAF7L ELOA NELFB ELOB NELFCD NELFA NELFE NCBP1 GTF2A1 GTF2A2 CTDP1 RNMT TAF9 POLR2A POLR2B POLR2C POLR2D POLR2G TAF9B POLR2I TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 ESRRA TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GLS2 TXNRD1 FKBP5 PPP2CB;PPP2CA AXIN1 PPP2R5C PPP2R1B RET GATA3 HNF4A JAG1 PRDM1 MYC COX7A2L-1 ARNTL TNRC6C MOV10 ARNT2 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B BRD2 TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 COX7A2 TFAP2A WWOX TFAP2C TFAP2D KCTD1 TFAP2E;TFAP2B KCTD15 CSF1R CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 EAF1 EAF2 AKT2 AKT3 SNRPD3 SUPT6H AFF4 POMC SNRPE-2 SFN MLLT1 MLLT3 NLRC4 IWS1 CASP1 TXNIP SKP2 PRMT1 MET TCF7L1 DLX5 SOX2 MYB TSC2 TSC1 STAT1 TJP1 ZFPM1 GATA4 GATA2 GATA1 NFE2 SNRPF SNRPB IRAK1 CAV1 YWHAQ YWHAH PDPK1 SNRPG-2 PTPN11 CALM3;CALM1 PABPN1-1 SOD2 IFNG CCNE2 CCNE1 PLK2 MDC1 ATF2 TP53RK NOC2L SGK1-1 KAT5 CHEK2 CHEK1 TP63 DAXX HUS1 PRKAB1 RRAGA RRAGC RRAGB DDIT4 RRAGD DNA2 MAML2 RHNO1 MAML1 E2F4-1 L3MBTL1 MEAF6 MAPKAP1 PRDX2 TFDP1 NUAK1 PCBP4 PRDX1 TFDP2 TP53BP2 ATRIP MAML3 PRELID3A NOTCH2 NOTCH3 BANP BARD1 NOTCH4 PLK3 PRELID1 E2F1 CRADD GADD45A TPX2 RAD17 JUN ATM SNW1 CDK12 MAMLD1 CDK13 ATR TP73 CDKN1A BTG2 CDKN1B SETD9 PRKAG1 CHM BRCA1 PRKAG3 RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 PRMT5 BRD1 RMI2 CNOT6L RMI1 TOP3A FOS DDB2 RAD51D BRPF3-1 PCNA WRN PLAGL1 PERP PMS2 SOCS3 RICTOR BRD7 PTPN1 TIGAR RPA1 RPA2 CDK4 MLH1 HIPK1 CDK2 POU4F1 POU4F2 HIPK2 TTC5 RPA3 CCNG1 RAD1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 MRE11 SESN3 SESN2 KMT5A NBN BNIP3L USP7 IGFBP3 USP2 CDC25C MSH2 FANCD2 KAT6A MAPKAPK5 SMYD2-1 BLM MDM2-2 NDRG1 NPM1-2 SLC38A9 BCL2L14 ZNF420 MAP2K6 FANCI BRPF1 CNOT10 FANCC CNOT4 CNOT6 RGCC TP53I3 CNOT7 BCL6 CNOT11 RHEB CNOT1 CNOT2 JMY CNOT3 PIN1 MDM4 RAD9B CNOT8 CNOT9 RAD9A PRR5 DYRK2 PPP1R13B PIDD1 EXO1 CASP6 PPP1R13L MLST8 CASP2 TOPBP1 ZNF385A RFC5 RFC3 RFC4 APAF1 RFC2 RABGGTB RABGGTA RBL2 RBL1 BIRC5 TMEM219 PRKAA1 TRPC3 RNF34 AURKB TP53INP1 RBBP8 RFFL E2F7 E2F8 ARID3A PML MTOR RAD50 BAX HDAC10 FASLG EPC1 PRDM7;PRDM9 FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A PRKCQ PRMT6 PBRM1 ACTL6B BDNF CDK5R1 GCK YEATS4 MAPK1 MAPK3 ARID2 CCNA2-1 CCNA1 KDM5B PRKAB2 HDAC8 SCO2 REST PRKAG2 MED15 MED26 MED25 KIT PPARD PRKCB RAMAC LSM10 LSM11 NABP1-1 INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 ICE1 ICE2 SSU72 NABP2 PHAX ZNF143 G6PC1 ELL2 ELL3 ZC3H8 RPRD2 RPAP2 SP1 RPRD1B RPRD1A SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 PTEN CPSF2-1 NUDT21 RRM2B USP9X PRKAA2 BRIP1 WDR61 APOE PCK1 WDR33 PAPOLA FIP1L1 COX7B COX7C COX8A SREBF1 COX8C CSTF3 CSTF2 SRC SRF COX5B COX5A COX6C CPSF4 CPSF1 CPSF3 COX6A1 COX6A2 COX6B2 COX6B1 SRRT CTR9 RTF1 SYMPK PAF1 HDAC4 UBE2I THRB VDR NR1H2 RORA NR3C1 ESR1 NR2C1 NR4A2 NR5A1 AR RXRA SUMO1 RARA CARM1 PGR PPARG PPARA CSTF2T TP53 GLS NAMPT GAMT CLP1 CSNK2A2 CGA NR1D1 CSNK2B CPSF7 GPI PCF11 STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation FLT3LG PTPN11 STAT5A STAT5B GAB2 FLT3 APAP ADME%REACTOME DATABASE ID RELEASE 97%9753281 APAP ADME UGT1A1;UGT1A6 GGT5 ABCC5 GGT7 CNDP2 GGT6 GSTP1 ABCC4 GSTT1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GGT1 SULT2A1-4 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ABCG2 CYP2E1 NAT1 GSTM1;GSTM2-1 ACY1;ABHD14A-ACY1 ABCC3 ABCC1 ABCC2 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 97%5658034 HHAT G278V doesn't palmitoylate Hh-Np HHAT DHH IHH SHH TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts CPSF1 NCBP1 NUP133 CPSF3 NUP107 NUP188 NUP50 POM121;POM121C NUP54 EIF4E SYMPK NUP210 NUP93 FIP1L1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NXF1 NUP88 SLBP RAE1 RANBP2 NUP155 NUP153 ALYREF NCBP2-1 CPSF2-1 NUP35 NUP62 NUP37 WDR33 NDC1 CPSF4 SEC13 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME DATABASE ID RELEASE 97%2206282 MPS IIIB - Sanfilippo syndrome B NAGLU TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 97%69895 Transcriptional activation of cell cycle inhibitor p21 TP53 PCBP4 CDKN1A ZNF385A FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.3 Formation of Senescence-Associated Heterochromatin Foci (SAHF) UBN1 H1-0 H1-3 H1-2 H1-5 H1-4 HIRA EP400 HMGA2 CABIN1 TP53 LMNB1 ASF1A RB1 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 97%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins VPS37C VPS37D VPS37A VPS37B RPS27A NMT2 UBAP1 UBB;UBC VPS28 TSG101 MVB12B MVB12A UBA52 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME%R-HSA-9616333.3 Defective Base Excision Repair Associated with NTHL1 NTHL1 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes BDNF GEM ARNTL CDK5R1 RBFOX3 ARNT2 NPAS4 MDM2-2 RET CDK5 IQSEC3 NAMPT INS;INS-IGF2 SYT10 MAPK1 PLK2 ARNT MAPK3 FOS CREBBP XPO1 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant ADAMTS13 VWF CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%389356 CD28 co-stimulation PPP2R1A PIK3CA MTOR PIK3R3 CD28 PIK3R6 PIK3R5 AKT2 GRAP2 AKT3 PAK1 RAC1 YES1 CD86 CD80 PAK3 LYN CTLA4 AKT1 PAK2 THEM4 RICTOR PRR5 LCK PDPK1 PPP2CB;PPP2CA MLST8 PPP2R5B PPP2R5A PPP2R5D TRIB3 PPP2R5C MAP3K14 CDC42 PIK3CD PPP2R1B MAPKAP1 PIK3CG PPP2R5E PIK3R2 PIK3CB MAP3K8 VAV1 PIK3R1 FYN SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.5 Selenocysteine synthesis RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 SECISBP2 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 SARS1 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 SEPSECS RPL18A RPL23A FAU RPL12-1 RPS27A SEPHS2 RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 EEFSEC RPS6 RPL13 RPL18 RPSA RPL17 PSTK RPL19 RPS15 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis GSK3A TRIM27 CTSG SFPQ-1 KPNA1 RPS27A RNF213-2 NOS2 PGK1 HGS ATP6V1H UBB;UBC CORO1A RAB7A RAB5A KPNB1 MAPK1 MAPK3 VPS33B ENO1 DUSP16 UBA52 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB-1 HADHA ACADL ECI1 ACADM DECR1 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 97%2214320 Anchoring fibril formation BMP1 LAMA3 TLL2 TLL1 LAMC2 LAMB3 COL7A1 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013409 RHOJ GTPase cycle GJA1 ARHGEF7 STOM WAS PAK1 IQGAP3 FMNL3 SLC4A7 DOCK8 PAK3 SNAP23 PAK4 GIT2 JUP CAV1 MPP7 ARHGAP1 NIPSNAP2 WASL SYDE1 CDC42 CDC42EP1 ARL13B VAMP3 PIK3R2 PIK3R1 ARHGAP5 CDC42BPB ARHGAP21 CDC42BPA CPNE8 OPHN1 TMPO ARHGAP35 SCRIB WWP2 VANGL1 DEPDC1B OCRL RAB7A ARHGAP26 ARHGAP32 PAK2 DIAPH3 GIT1 TRIO TFRC LAMTOR1 WIPF2 STEAP3 FNBP1L PREX1 RHOJ SLC1A5 FNBP1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 97%69541 Stabilization of p53 PSMA6 PSMC5 ATM PSMA3 PSMC6 PSMA4 MDM2-2 PSMC3 PSMA1 PSMC4 PSMC1 MDM4 UBA52 PSMD12 PSMD11 CHEK2 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PHF20 PSMD6 PSMB4 RPS27A PSMD7 CDKN2A PSMB5 PSMB2 PSMB3 UBB;UBC TP53 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 COP1 PSMC2-1 PSMA2-1 PSMA5 SEM1 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%6784531 tRNA processing in the nucleus NUP133 NUP50 POM121;POM121C NUP54 NUP42 NUP43 RAE1 RANBP2 POP5 POP7 POP1 CSTF2 TSEN15 POP4 RPP30 RTCB ZBTB8OS TSEN2 TSEN54 RPP38 RPP21 RPP25 NUP35 TSEN34 DDX1 RPP14 C2orf49 CLP1 RTRAF RAN RPP40 XPOT FAM98B NUP37 CPSF4 CPSF1 NUP107 NUP188 NUP210 NUP93 TRNT1 NUP205 AAAS NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 NUP62 NDC1 SEC13 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%419037 NCAM1 interactions PSPN COL6A2 GFRA2 GFRA4 COL4A3 ARTN COL6A1 CNTN2 COL6A3 COL6A6 COL4A5 COL6A5 CACNA1H CACNB2 CACNB3 GFRA1 GDNF ST8SIA2 CACNA1D AGRN CACNA1C COL9A1 ST8SIA4 COL9A3 COL9A2 CACNA1G CACNA1I CACNB1 NCAN NRTN CACNB4 NCAM1 COL4A2 CACNA1S COL4A1 PRNP COL4A4 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 97%5654228 Phospholipase C-mediated cascade; FGFR4 FGF20 FGF23 FGF2 KLB FGF19 PLCG1 FGFR4 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 INSULIN RECEPTOR RECYCLING%REACTOME%R-HSA-77387.6 Insulin receptor recycling ATP6V0B INSR ATP6V1B2 ATP6V1E1 ATP6V0C ATP6V1E2 ATP6V1B1 ATP6V1G1 ATP6V1G2 CTSD IDE PTPRF ATP6V1H INS;INS-IGF2 ATP6V1G3 ATP6V0D1 ATP6V0D2 ATP6V1A ATP6V0A2 ATP6V0A4 ATP6V0E2;ATP6V0E1 ATP6V1D PTPN1 ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 ATP6AP1 TCIRG1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 97%5654716 Downstream signaling of activated FGFR4 FRS2 FGF20 GAB1 SOS1 PIK3CA FGF23 PTPN11 FGF2 KLB FGF19 PLCG1 FGFR4 HRAS PIK3R1 FGF1 FGF6 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation PSMA6 PSMA3 PSMA4 PSMA7 PSMA1 PSMB6 PSMB7 PSME2 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSME1 PSMB10 PSMB8 PSMB9 PSMA2-1 PSMA5 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.2 RUNX1 regulates transcription of genes involved in WNT signaling RUNX1 FOXP3 RSPO3 AXIN1 ESR1 CBFB TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6787450.10 tRNA modification in the mitochondrion TRMT10C PRORP YRDC TRMU OSGEPL1 MTO1 HSD17B10 TRMT61B GTPBP3 TRIT1 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9818749 Regulation of NFE2L2 gene expression NOTCH1 NFKB1 MAFK RELA NFE2L2 CREBBP MYC EP300 DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734195 Defective APRT disrupts adenine salvage APRT MIRO GTPASE CYCLE%REACTOME%R-HSA-9715370.3 Miro GTPase Cycle MFN1 MYO19 RHOT1 MFN2 TRAK1 TRAK2 RAP1GDS1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 97%204005 COPII-mediated vesicle transport TGFA CTSC SEC31A TRAPPC3 GOSR2 TRAPPC1 TRAPPC4 TRAPPC5 SAR1B CTSZ TRAPPC9 GOLGA2 TRAPPC2;TRAPPC2B GRIA1 TRAPPC6A NSF TMED2-1 TRAPPC6B RAB1A SEC22B SEC23A RAB1B LMAN1 SEC24B TRAPPC10 STX5 SEC24A YKT6 AREG SEC24C MCFD2 SERPINA1 PPP6C PPP6R1 PPP6R3 LMAN1L GORASP1 SEC22A SEC22C CSNK1D NAPB TMED10 STX17 SCFD1 LMAN2L USO1 NAPG LMAN2 SEC31B ANKRD28 SEC23IP COL7A1 CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 FOLR1 CNIH3 BET1 F5 SEC24D-1 F8 NAPA CD59 TFG TRAPPC2L TBC1D20 PREB SEC13 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis PPIA PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 97%8849470 PTK6 Regulates Cell Cycle PTK6 CDKN1B CCNE1 CDK4 CDK2 CCND1 TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-HSA-171319.5 Telomere Extension By Telomerase DKC1 PIF1 NHP2 SHQ1 WRAP53 CDK2 ACD TINF2 TERF2 PPP6C POT1 CCNA2-1 CCNA1 TERT TERF2IP PPP6R3 TERF1-1 RUVBL2 RUVBL1 ANKRD28 NOP10 RTEL1 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) TLR5 MYD88 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME%R-HSA-5579028.6 Defective CYP17A1 causes AH5 CYP17A1 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 97%1614517 Sulfide oxidation to sulfate SUOX TSTD1 ETHE1 TST SQOR SLC25A10 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins PSMD12 PSMD11 WNT5A PSMD14 PSMD13 PSMA7 FZD1 PSMD8 FZD3 FZD2 PSMB6 FZD5 PSMB7 FZD4 PSMD6 FZD7 PSMB4 PSMD7 PARD6A FZD8 PSMB5 SMURF2 PSMB2 SMURF1 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 PRICKLE1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 SCRIB PSMC1 VANGL2 UBA52 RPS27A UBB;UBC DVL2 SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.7 Sphingolipid metabolism GBA ARSD-1 ARSL ARSJ B4GALT6 ARSK ARSH ARSI B4GALT5 ST8SIA5 ARSG ALDH3B2;ALDH3B1 CTSA ACER2 ACER1 CSNK1G2 ACER3 SGPP2 SGPP1 ST3GAL2 ST3GAL3 SPTLC1 SPTLC3 PSAP M6PR GAL3ST1 ORMDL2 ORMDL3 UGT8 HEXB GM2A HEXA ORMDL1 GLB1L3 GLB1L2 SMPD3 B3GALNT1 GLB1L GLB1 SMPD2 SMPD4 SMPD1 ARSB SPHK2 ENPP7 FUT2 FUT1 VAPA SUMF2 VAPB SUMF1 GBA2 SAMD8 A4GALT PLPP3 PLPP2 PLPP1 DEGS1 DEGS2 UGCG SGPL1 OSBP KDSR B3GALT4 GALC GLA SPTSSB B3GNT5 CERS3 CERS4 PRKD3 CERS5 CERS6 PRKD2 PRKD1 CERS1 ST6GALNAC5 CERS2 ST6GALNAC6 ST3GAL5 PPM1L SPNS2 FA2H ABCG2 CERK STS MFSD2B SGMS1 SGMS2 NEU2 SPHK1 NEU3 ASAH1 ASAH2 NEU1 ARSA B4GALNT1 ABCC1 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 97%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance RPS14 RPS17 SPTBN2 RPS16 RPS19 CLASP2 RPS18 LIMK2 LIMK1 CSNK2A1;CSNK2A3 RPS11 RPL10A RPS10 RPS13 RPS12 SDC2 CNTN1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 DLG1 RPS23 ERBB2 PLCG1 NRP1 EGFR RPL36AL-1 PRKACA-1 GAB1 MET MYO10 HSP90AA1 RPS27L RPS15A GPC1 RPS3 UBA52 NELL2 RPS2 SLIT3 RPL18A KIF4B;KIF4A ST8SIA2 FAU AGRN RPS27A RPS6KA3 RPS6KA5 CLASP1 RPS6KA2 UBB;UBC RPS6KA1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA CNTN6 CHL1 ITGA2 ITGA10 ANK1 UNC5A GRIN2B DCC UNC5B UNC5C UNC5D NTN1 ADAM10 HSP90AB1 RPS4X RPS3A PSEN1 NCSTN CDC42 COL9A1 ST8SIA4 COL9A3 COL9A2 LAMC1 PTPN11 RPL15-1 MMP2 MMP9 PITPNA RPS6KA6 CFL1 PAK2 DLG3 MSN ITGA5 LAMB1 CACNA1H YES1 GRIN1 MYH9 LDB1 RPL10;RPL10L-1 MAPK7 RPLP0 ARHGAP35 RAC1 RPLP2 RPL36-1 RHOA DOK1 DOCK1 ITGA2B PSEN2 APH1A APH1B PLXNA4 ABL1 FLRT3 EIF4A3 RPL22L1 CASC3 ITGAV CDK5 ACTB-1 PSENEN RPL37A-1 GSK3B RBM8A MAGOH;MAGOHB UPF3B RNPS1 PIK3CD TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 RPL13A-1 CXCL12 DOK2 SHC1-1 PRKCQ ITGB3 LYN TIAM1 CDK5R1 RPL23A MAP2K2;MAP2K1 MAPK1 SEMA5A MAPK3 SOS1 GRB10 PIK3R3 MSI1 HOXA2 ISL1 COL4A5 GSPT2 GSPT1 LHX3 LHX2 LHX4 LHX9 USP33 ROBO1 UPF2 ETF1 ZSWIM8 SLIT1 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 WASL PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 PSMD3 ANK3 PSMB1 PSMD1 EPHA4 ADRM1 ROCK1 PSMC2-1 PSMA2-1 COL4A2 PSMA5 COL4A1 COL4A4 SEM1 PSMA6 COL6A2 PSMC5 PSMA3 COL4A3 PSMC6 COL6A1 PSMA4 PSMC3 PSMA1 PSMC4 COL6A3 PSMC1 COL6A6 COL6A5 EPHA2 PRKCA RPL12-1 TRIO ITSN1 HSPA8 PABPC1;PABPC3 EIF4G1 MYL6 RBX1 NGEF TREM2 GAB2 TYROBP NUMB RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 PRKACB-1 RPL34 PRKAR2A SDCBP RPL8 ARPC1B ARPC1A RPL9 RPL6 RPL7 RPL35 RPL38 DAG1 RPL39 RPL21 RPL23 RPL22 HRAS FYN RASA1 CACNA1G CACNA1I NRTN RPL24 NCAM1 NRAS CACNA1S RPL27 PRNP PSPN RPL26 GFRA2 RPL29 GFRA4 RPL28 ARTN FARP2 CNTN2 RPL3L RPLP1-2 DPYSL4 DPYSL5 DPYSL2 DPYSL3 PLXNC1 SEMA6A SEMA6D PLXND1 ITGA1 SEMA7A SEMA3A ALCAM CRMP1 SCN11A SEMA3E SCN10A RRAS AGAP2 PLXNA2 L1CAM PLXNA3 LYPLA2 SEMA4A DSCAML1 CD72 SHC3 SEMA4D RAP1GAP PTPRC DAB1 FES PTPRA PLXNB3 CNTNAP1 SPTB ITGA9 ELOC-1 NTN4 ABLIM1 RPL11 NEO1 ABLIM2 RPL14 ABLIM3 NFASC ELOB RPL13 EPHB6 RPL18 RPS6KA4 RPL17 CACNB1 EPHB2 RPL19 CACNB4 EPHB1 EPHB4 SCN1B PLXNA1 EPHB3 ABL2 SCN1A SRGAP3 EPHA5 NCBP1 SRGAP2 EPHA7 SRGAP1 EPHA6 ARPC4 EPHA8 ARPC5 ANK2 SHTN1 KCNQ2 KCNQ3 ARPC2 EPHA1 ARPC3 EPHA3 SPTBN4 SPTBN5 PLXNB1 EPHA10 MYL12A SCN3B SCN3A CD24 SCN2A SCN2B NRP2 VLDLR CAP1 CXCR4 NCK2 GFRA3 IRS2 RGMB CACNB2 NCK1 RGMA CACNB3 RELN CAP2 ACTR2 SCN9A NRCAM DSCAM DOK4 DOK5 SCN8A DOK6 EFNA5 EFNA4 EVL TLN1 SPTA1 EFNB2 PFN2-1 EFNB1 SOS2 EFNB3 ROCK2 EFNA1 SRC EFNA3 EFNA2 NCBP2-1 HJV SCN5A GAP43 DCX SCN4A CLTB SCN4B SHANK3 LAMA1 PPP3CB SCN7A PDLIM7 CLTCL1 RPL7A NCAN PFN1 GRB7 RPL35A KALRN MYL12B SPTBN1 CLTC PTK2 CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 SPTAN1 GIT1 CACNA1D VAV3 CACNA1C RHOC VAV2 RHOB SIAH2 SIAH1 ARHGEF7 ITGB1 ROBO2 RET PAK1 PAK3 PAK5 PAK4 MYO9B SLIT2 GFRA1 BUB1B-PAK6;PAK6 VASP ARHGAP39 GDNF ENAH ACTG1 PIK3R2 PIK3CB PIK3R1 CUL2 AKAP5 FRS2 ARHGEF28 PIK3CA CSNK2A2 RANBP9 MYH14 MYH11 EZR MYH10 CSNK2B RPL5-1 RDX DLG4 ACTR3-1 RND1 ARHGEF11 ARHGEF12 SH3KBP1 RPS15 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins RNF2 DNMT3B CBX8 SUMO1 PHC2 PHC1 DNMT3A CBX4 CBX2 PHC3 BMI1 UBE2I RING1 DNMT1 PCGF2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization ADAMTS2 ADAMTS3 P4HB COL4A5 ADAMTS14 SDC4 SDC2 VCAM1 SDC3 ITGB2 COLGALT2 ITGB4 LOXL3 PLOD3 LOXL4 SDC1 PLOD2 PLOD1 LOXL1 LOXL2 COL10A1 COLGALT1 COL27A1 P3H2 P3H1 PCOLCE P3H3 COL2A1 LOX COL4A2 ADAM12 COL4A1 COL4A4 COL6A2 PXDN COL4A3 PDGFA COL6A1 COL8A2 COL4A6 COL21A1 COL8A1 COL6A3 ITGA6 CD47 COL6A6 COL6A5 PPIB PLEC CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 CD151 PCOLCE2 COL11A1 COL11A2 SERPINH1 COL28A1 TTR CRTAP COL24A1 ADAM19 COL22A1 COL3A1 P4HA1 COL5A1 P4HA2 COL5A3 P4HA3 COL7A1 COL5A2 COL20A1 PRKCA AGRN ITGAM PDGFB ITGA2 ITGA10 COL16A1 CTRB1;CTRB2 COL12A1 CAPN8 CAPN9 CAPNS1 CAPN6 COL1A1 CDH1 CAPNS2 COL1A2 CAPN7 BSG CAPN5 CAPN2 CAPN3 CAPN1 CAST PHYKPL COL23A1 ADAM10 HSPG2 BCAN ADAM17 ADAM15 OPTC ADAM9 ADAM8 COL17A1 COL13A1 HTRA1 F11R PSEN1 DAG1 FN1 NID1 KLK7 ADAMTS16 SCUBE3 NCSTN SCUBE1 ADAMTS18 A2M ELANE BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 LAMC2 LAMC1 CTSS MMP20 NCAM1 ADAMTS4 ADAMTS5 MMP25 MMP24 ADAMTS1 CTSK CASP3 TIMP2 KLK3;KLK2 KDR CTSG TIMP1 ADAMTS8 CTSD ADAMTS9 CTSB CTSV;CTSL MMP7 COL25A1 MMP1 MMP2 MMP3 MMP8 MMP9 DCN MMP10 MMP12 CASK MMP11 MMP14 MMP13 MMP16 MMP15 MMP17 MMP19 ITGAL CD44 TPSAB1;TPSB2;TPSD1 LAMA5 COL15A1 TMPRSS6 ITGA1 ITGA4 LAMA3 FURIN PLG COL19A1 ACAN ITGA5 SPOCK3 SPP1 COL26A1 LAMB3 CMA1 LAMB1 CAPN13 CAPN14 CAPN11 PRSS3;PRSS2;PRSS1 ITGA9 CAPN12 NTN4 CAPN10 TLL2 TLL1 KLKB1 FMOD LUM TRAPPC4 BMP2 SERPINE1 LAMA1 PECAM1 SPARC DMP1 MUSK DTNA DTNB GDF5 SSPN NCAN DDR1 PTPRS BGN MATN1 MATN4 MATN3 VCAN DDR2 TNXB DRP2 DMD JAM2 JAM3 ACTN1 DSPP TNC COMP EFEMP2 EFEMP1 IBSP TNN TNR UTRN FBN2 FBN3 FBLN1 FBLN2 NID2 FBLN5 BMP7 ITGA11 FBN1 LAMC3 ITGAE HAPLN1 SGCE SGCD SGCA SGCB ITGAX SGCG SNTA1 ITGA2B ITGA3 NRXN1;NRXN3;NRXN2 SH3PXD2A ASPN ITGAD ITGA7 LAMA2 LAMA4 LRP4 LAMB2 SGCZ MFAP5 MFAP4 MFAP3 LTBP4 MFAP2 LTBP2 SNTB1 LTBP3 SNTB2 LTBP1 TGFB2 TGFB3 ITGB1 BMP10 ITGB5 ITGB8 ITGAV ITGB6 FGF2 BMP4 ITGA8 THBS1 TGFB1 VTN ITGB3 FGB ICAM3 FGA ICAM4 ICAM5 FGG ITGB7 ICAM2 ICAM1 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance CCNA2-1 CCNA1 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C POLR2D POLR2G SMARCA5 POLR2I DAXX PRIM2 PRIM1 H2AC20 WRAP53 POLA1 POLA2 H2AB2;H2AB3;H2AB1 DNA2 CENPX KNL1 H2AJ HJURP TERT RSF1 MIS18BP1 OIP5 CENPW MIS18A H2BC5 PCNA WRN H2BC1 RPA1 RPA2 CDK2 RPA3 H2AC4 RTEL1 DSCC1 CHTF18 BLM CTC1 STN1 TEN1 CENPN-2 NPM1-2 ACD TINF2 ATRX TERF2 POT1 TERF2IP TERF1-1 POLD1 H2BC21 H2AZ2;H2AZ1 RFC5 RFC3 RFC4 RFC2 CENPA CENPC CENPS-CORT;CORT;CENPS DKC1 CENPT NHP2 CENPU RBBP4 PPP6C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E LIG1 PPP6R3 CENPH POLR2F POLR2H RBBP7 CENPI POLR2L CENPK RFC1 CENPL CENPM H2BC15;H2BC3;H2BC11;H2BC12 ANKRD28 NOP10 CENPO CENPP CENPQ PIF1 SHQ1 POLD3 POLR2J;POLR2J2;POLR2J3 POLD4 POLD2 FEN1 RUVBL2 RUVBL1 ITGB3BP H2AC14 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade S100A8 TLR2 TBK1 DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 ITGB2 SOCS1 RIPK3 APP NFKB2 TLR6 IKBKE CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC UBE2D3-1 SKP1 ECSIT BIRC2 CHUK BIRC3 BTK OPTN-1 FBXW11 IKBKB IKBKG FOS UBA52 DNM1 DNM2 CUL1 DNM3 TANK MAPKAPK2 LBP PPP2CB;PPP2CA CD180 PPP2R5D ATF1 LY86 RPS27A ELK1 ITGAM RPS6KA3 PPP2R1B S100A1 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 IRF3 TRAF3 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 PTPN11 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 PLCG2 TRAF2 PELI1 TICAM1 CASP8 LRRC14 USP14 PELI3 RIPK1 PELI2 NLRC5 CD14 TIFA FADD HMGB1-1 TLR4 MAP3K1 SIGIRR IRAK3 FGB UBE2D3;UBE2D2 NFKBIA FGA FGG UBE2D1 RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 PTPN4 TLR1 BPI S100A9 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA DIS3 XRN1 MAPKAPK2 ZFP36L1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 YWHAB DCP1A AKT1 PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism PLAAT1 PLA2G4A PLAAT3 PLAAT2 PLAAT5 GPCPD1 PIK3R3 PLAAT4 HADHA PIK3R6 PITPNM1 PIK3R5 PITPNM3 PITPNM2 CSNK2A1;CSNK2A3 MGLL PLA2G1B AGPAT1 AGPAT2 ALPG;ALPP;ALPI-1 SELENOI AGPAT3 AGPAT4 GPAT4 AWAT2 GPAT3 TPTE;TPTE2 GPAT2 CEPT1 CDIPT PLA2G10;LOC100652777 PLA2G2F BCHE PLA2G2D PIK3R4 PLA2G2E AGK PNPLA8 PIKFYVE MBOAT7 MBOAT1 DDHD2 MTM1 MBOAT2 DDHD1 ETNPPL GPAM LPCAT4 ETNK2 RAB4A LPCAT3 ETNK1 LPCAT2 PNPLA3 CHPT1 PIP5K1A LPIN1 PIP5K1B LPIN2 SYNJ2 LPIN3 PIP5K1C PNPLA2 SYNJ1 RAB5A MTMR10 MTMR12 MTMR14 PLEKHA1 PIK3C2G PIK3C2A PLEKHA2 PIK3C2B PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 PLEKHA8 SBF1 SBF2 RAB14 BMX GDPD1 GDPD3 GDPD5 PIP4K2A PIP4K2B PTEN PIP4K2C PIK3C3 PIP4P1 PI4KA PI4KB VAC14 FIG4 RUFY1 MTMR1 MTMR2 MTMR3 MTMR8 MTMR9 MTMR4 MTMR6 MTMR7 PNPLA7 ARF1 PNPLA6 INPPL1 PTPN13 ENPP6 GDE1 SACM1L INPP4A INPP4B TNFAIP8 INPP5F INPP5D INPP5E INPP5J INPP5K TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 PI4K2B PIK3CD PIK3CG PIK3R2 LPGAT1 PIK3CB PITPNB CPNE7 CPNE6 PIK3R1 LCLAT1 PLB1 PLA2G2A-1 LIPI LIPH JMJD7-PLA2G4B;PLA2G4B PI4K2A CPNE3 MFSD2A DGAT2 MIGA2 PCYT2 PIK3CA MIGA1 DGAT1 STARD7 CSNK2A2 GPD1L-1 PISD PLA2G15 ABHD3-2 GNPAT PHOSPHO1 GPD2 GPD1 CSNK2B PGP PLBD1 PLA2R1 PLA1A OCRL CDS1 ABHD4 CHAT PLD4 PLA2G3 PLD6 PLA2G5 PLD1 PLA2G6 PLD3 PLD2 PGS1 PTDSS2 PTDSS1 PTPMT1 OSBPL8 TMEM86B CHKB OSBPL5 CHKA STARD10 DGAT2L6 CRLS1 PEMT CDS2 SLC44A5 ACHE SLC44A3 HADHB-1 SLC44A4 SLC44A1 SLC44A2 LPCAT1 PCTP TAZ OSBPL10 ACP6 AGPAT5-1 PCYT1B PLA2G12A PLA2G4F PCYT1A PLA2G4D PLA2G4E REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 97%9821993 Replacement of protamines by nucleosomes in the male pronucleus H1-8 METTL23 HIRA H2BC15;H2BC3;H2BC11;H2BC12 SRPK1 H2BC5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NPM2 H2BC21 H2BC1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918440 Defective visual phototransduction due to RDH12 loss of function RDH12 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN XRCC6 TBK1 IFI16 PRKDC NLRP4 MRE11 XRCC5 TREX1 DDX41 STING1 IRF3 DTX4 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 97%1296053 Classical Kir channels KCNJ2 KCNJ12;KCNJ18 KCNJ4 KCNJ14 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 97%5579027 Defective CYP27B1 causes VDDR1B CYP2R1 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing APOBEC1 APOBEC2 ADAR ADARB1 A1CF TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602566 TICAM1 deficiency - HSE TLR3 TICAM1 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD ABCA1 APOA1 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.2 Aggregated β-amyloid induces FXII autocatalysis F12 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception OR52A5-2 OR2V2 OR11A1 OR8A1 METAP1 METAP2 OR8I2 OR10G9;OR10G7 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 TAS2R3-1 OR5D18 OR56B1-1 OR10W1 OR8B3;OR8B2-1 OR5B2 OR5D14 AWAT2 OR5D13 EBF1 TAS2R16 OR52M1 SDC4 OR10V1 OR4C12 OR6C3 SDC2 OR5A2 SDC3 OR5A1 OR4C15 OR9I1 TAS2R40 TAS2R41 OR2AG1;OR2AG2 OR10T2 OR52L1 OR4C45-1 OR52R1-2 OR6B2 OR6B1 OR2A25 OR51I2 OR2M2;OR2M3;OR2M7;OR2M5 OR10S1 EPB41L1 OR51I1 TAS2R39 RPE65 OR4D11 SDC1 OR4D10 OR2Z1 OR6A2 OR9G4 OR4E1 RDH8 OR8K5-1 OR51Q1 OR2B6;OR2B2-1 OR4D9 OR5B12 OR5AP2 OR4D6 OR4D5 OR4D2 OR4D1 OR2H1-1 OR10Z1 OR2S2-1 OR5P2-4 OR4C6 OR4A15 ANO2 OR4C3 OR3A2 APOA2 OR3A1 APOA1 OR8K3 APOA4 GUCY2D OR8K1 MYO1C OR4C11-1 HSD17B6 OR2L3;OR2L8;OR2L2;OR2L5-1 OR5AN1 OR8U8;OR8U1;OR8U9 OR6C2;OR6C68 TTR OR6F1 BCO2 OR2T2;OR2T35 BCO1 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GPC1 OR51M1 OTOP1 OR10X1 APOC3 GPC3 OR8J3-1 OR5C1 GPC2 OR1C1 GPC5 OR2G2-1 OR51D1 GPC4 OR6M1 SDR9C7 APOC2 OR7E24-1 GPC6 OR2T11 OR1L1;OR1L3;OR1L8 OR5AK2-2 OR2D3 OR2D2 OR1B1 OR52E4 OR5J2 PRH1-TAS2R14;TAS2R14-3 CAMKMT RGS9BP AGRN OR52E2-1 OR2AT4-1 OR2C3 OR6K6 OR2C1 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 GRK1 GRK7 OR51B6 OR4F6 OR2B3 OR10K2 OR2F1-2 OR2T29;OR2T5-3 OR14A2-1 OR2AJ1 OR51A4 KCNMB1 OR2A5 OR51A7 KCNMA1 TAS2R7 OR52J3 RTP2 TAS2R8 RTP1 OR4M1 OR10R2 OR8U3 OR6Q1 OR11H1;OR11H12 OR52I1;OR52I2-1 OR4F21;OR4F16;OR4F29;OR4F3 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW GRM4 OR9G9;OR9G1 OR7C1;OR7C2-9 TAS2R1 TAS2R4 CAPZB OR51G2 OR51G1 OR1F1 OR2H2 OR4L1 OR5B3-13 DHRS3 OR6P1 OR10Q1 OR52E8;OR52E6 OR5M10;OR5M1-1 DHRS9 SAG HSPG2 OR2AP1 RDH10 OR2B11 OR4A47-3 OR51F2 OR5M9 OR51F1 OR2G6 OR4K5 OR4K3 OR5M3 OR4K2 OR4K1 OR10P1 TAS1R2 TAS1R1 TAS1R3 LOC118142757;GUCA1A OR51E1 OR1D2 OR51E2 OR6N2 OR6N1 OR4F15 CAPZA1 CAPZA2 PNLIP ATP2B1 CALM3;CALM1 CASK CHRNA9 GNAL GNGT1 MSN LRP10 LRP12 KCNJ2 LRAT GNG13 MYH9 RBP4 RBP2 GNB1 RBP1 GNB3 LDB1 RETSAT GPIHBP1 CNGA2 CNGA4 CNGB1 RHO VAMP2 GSN LPL TRPM5 TRPM4 LRP1 PRKCQ LRP2 LRP8 STX1A APOB LHX2 GRM1 CACNA2D2 RDH11 SLC17A8 SCNN1G SCNN1D SCNN1B SCNN1A RAB3A PRKCA SYN1 ADCY3 SNAP25 RDH12 GNAT3 FNTA CLPS OPN1SW RLBP1 CALHM1 CALHM3 NMT1 NMT2 PLCB2 APOM APOE SCN1B SCN3A SCN2A SCN2B CACNB2 SCN9A ITPR3 SCN4B HSD17B1 PDE6B PDE6A FNTB;CHURC1-FNTB TWF1 SPTBN1 ABCA4 SPTAN1 CACNA1D OR11H4 OR2M4 OR4C13;OR4C46-2 OR6K3-1 OR1K1 OR4K17 OR1S1;OR1S2 OR4Q3 OR11H6 GNAT1 OR8G1;OR8G5 OR1J4 AKR1B15;AKR1B10 OR11G2 OR1J2 OR4P4 OR1J1 OR10AD1 OR6T1 RBP3 OR4K13 OR7A10;OR7A17-11 OR51V1-1 OR13J1 OR2K2 OR1I1 OR6S1 OR5M11 OR5K4-1 OR10D3 OR8H2;OR8H3;OR8H1 OR14K1 OR4N5 OR5P3 OR10C1 OR5B17-3 LOC112268384;OR2A42;OR2A1 OR6C6-1 OR11L1 OR10H1;OR10H5;OR10H2 OR5W2 OR6Y1 OR52B2 OR52B6 OR5K3-3 OR1A1-1 OR1N2 OR1N1 OR6X1 OR1E1;OR1E2 OR52K1-1 OR52A1 OR5L2;OR5L1-1 OR1M1 OR4S2 OR5AC2-2 OR2AE1-2 OR10G2 OR14A16 OR10G3 OR8D2-1 OR7D4-5 OR4K14-1 PLB1 OR5T1 OR6V1 RIPOR2 OR10G6 CLIC5 OR6C4-1 CIB2 GUCA1C PJVK EPS8 OR10K1-1 OR52W1 PCLO OR5AS1 BSN OR4F5;OR4F17;OR4F4 TPRN PLS1 OR2T6 TMC1 OR13C9 OR2T1 ESPN-1 OR13C8 MYO7A OR2L13 SYP TMC2 OR4X1 OR9A4 MYO3B OR51T1 DNAJC5 PPEF1 MYO3A OR5V1-2 KCNQ4 FSCN2 OR5AR1 OR2V1-1 EZR OR2A2;OR2A14 PCDH15 OR1Q1 USH1C OR12D1;OR12D2-1 CABP2 OR51S1 CABP1 LRRC52 OR7G2;OR7G1-14 ESPNL OR14C36-8 OR5B21 CDH23 STRA6 OR2J1;OR2J2;OR2J3-2 OTOG REEP1 OTOF OR13A1 CHRNA10 OR2T27;OR2T7 XIRP2 OR4N2-1 KCNN2 OR4C16-2 EPS8L2 OR14J1 MPP1 GRXCR1 OR13H1 GRXCR2 CNGA1 WHRN OR2Y1 SLC24A1 RDX OR8D4 OR56B4 LHFPL5 OR8D1 OTOGL TMIE OR6C70 OR6C76 USH1G STRC OR6C75 OR6C74 MYO15A SLC26A5 OR13G1 OR13C3;OR13C4 OR4B1-2 OR10A7 OR1L4;OR1L6-1 OR6C1-1 OR56A4 OR10A4 OR56A3 OR10A3 OR10A5 OR2A7;LOC107987545;OR2A4 OR4A16;OR4A5-1 OR4X2-2 OR2W3 RDH5 OR8B8 OR2W1 CYP4V2 LDLR OR8B4 OR13F1 OR12D3 OR5AU1 RCVRN OR2T12;OR2T33;OR2T8-1 OR5K1;OR5K2 OR10J1-2 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559585 Oncogene Induced Senescence E2F2 CDK6 TNRC6C MOV10 MDM2-2 TNRC6A-1 AGO4 ETS2 AGO3;AGO1 TNRC6B ETS1 CDKN2B SP1 MDM4 UBA52 CDKN2D CDKN2C CDK4 ERF ID1 RPS27A CDKN2A UBB;UBC TP53 TFDP1 TFDP2 MAPK1 RB1 MAPK3 E2F1 E2F3 ROBO RECEPTORS BIND AKAP5%REACTOME%R-HSA-9010642.2 ROBO receptors bind AKAP5 PRKCA PPP3CB ROBO2 PRKACB-1 PRKAR2A PRKACA-1 AKAP5 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME%R-HSA-9665249.2 Resistance of ERBB2 KD mutants to afatinib CDC37 ERBB2 ERBIN HSP90AA1 DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants KIT DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%3781865 Diseases of glycosylation C1GALT1C1 DPM1 ADAMTS2 DPM2 ADAMTS3 DPM3 EXT1 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A EXT2 MUC15 ADAMTS6 FMOD ADAMTS7 LUM SBSPON CHSY1-1 MUC3A B4GALT7 MUC5AC ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 CTSA THSD4 MOGS ADAMTS10 PRELP ADAMTS15 ADAMTS14 SDC4 MUC1 KERA MUC2 ADAMTS19 B3GAT3 SDC2 ADAMTS17 SDC3 MUC7 MUC4 MUC6 SLC26A2 GALNT3 NOTCH1 MUC17 C1GALT1 MUC5B MUC20 MUC21 ST3GAL3 GALE LFNG B4GALT1 SDC1 NOTCH2 GFPT1 NOTCH3 ALG14 NOTCH4 ALG12 HEXB ALG11 NCAN HEXA BGN MUC13 VCAN GLB1 CSPG5 CHST6 RFT1 GPC1 GPC3 GPC2 GPC5 GPC4 PMM2 MGAT2 GPC6 CHST3 ADAMTS13 AGRN GALK1 GALT DPAGT1 MPI OGN HSPG2 BCAN DOLK SRD5A3 B3GALT6 B4GAT1 DAG1 LARGE1 ADAMTS16 POMGNT1 ADAMTS18 MAN1B1 PGM1 GNE ADAMTS4 ADAMTS5 THBS1 ADAMTS1 ALG8 ADAMTS8 ALG9 ALG6 ADAMTS9 ALG2 CHST14 ALG3 ALG1 MPDU1 DCN DHDDS GALM-2 OMD ACAN NUS1 PAPSS2 NEU1 POMT2 SEMA5A SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production NOS2 KPNB1 KPNA1 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 97%9694301 Maturation of replicase proteins ISCU DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 97%75205 Dissolution of Fibrin Clot SERPINB2 ANXA2 PLG SERPINE1 SERPINE2 SERPINF2 PLAUR PLAT SERPINB8 PLAU HRG SERPINB6-2 S100A10 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811436 COPI-independent Golgi-to-ER retrograde traffic BICD2 ACTR1A RAB6A GALNT2 PLA2G4A GALNT1 DYNC1LI1 PAFAH1B3 DYNC1LI2 PAFAH1B2 RAB18 RAB3GAP2 RAB3GAP1 RAB6B DYNC1I1 AGPAT3 CAPZA3 ACTR10 CAPZB PLA2G6 PAFAH1B1 DYNC1I2 DCTN2 DCTN6 DCTN5 DCTN3 DCTN4 DCTN1 DYNC1H1 CAPZA1 CAPZA2 BICD1 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME%R-HSA-9031525.2 LXRs regulate gene expression to limit cholesterol uptake NR1H3 RXRA RXRB MYLIP NR1H2 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9764562.1 Regulation of CDH1 mRNA translation by microRNAs MYCN TNRC6C CDH1 MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B MYC DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 97%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS HSPG2 GPC6 EXT1 EXT2 AGRN SDC1 GPC1 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 GPC4 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-HSA-8963693.6 Aspartate and asparagine metabolism ASNS SLC25A12 NAT8L GOT2-1 GOT1-1 SLC25A13 ASPA FOLH1B;FOLH1 GADL1 NAALAD2 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex ISY1;ISY1-RAB43 UVSSA RBX1 COPS4 COPS2 ERCC8 CDK7 POLR2E XAB2 POLR2F POLR2H MNAT1 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 UBA52 POLR2G PPIE ERCC2 ZNF830 POLR2I GTF2H1 DDB1 GTF2H3 ERCC6 GTF2H4 XPA COPS7B AQR COPS7A POLR2J;POLR2J2;POLR2J3 PRPF19 RPS27A TCEA1 CUL4A UBB;UBC COPS3 COPS6 GPS1 COPS5 COPS8 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH CUL4B USP7 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.6 Negative regulation of MAPK pathway PPP2R1A PTPN3 MARK3 DUSP5 DUSP2 DUSP1 PAQR3 PTPN7 ARAF DUSP4 DUSP6 RAF1 DUSP7 YWHAB PEBP1 DUSP16 DUSP10 PPP5C UBA52 PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D RPS27A PPP2R5C PPP2R1B DUSP8 DUSP9 PPP2R5E UBB;UBC MAP2K2;MAP2K1 MAPK1 HRAS BRAF MAPK3 KSR1 MAPK12 BRAP NRAS SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells SOS1 PIK3CA PTPN11 STAT3 GRAP2 PLCG2 IL34 GAB2 INPPL1 GAB3 INPP5D YES1 THOC5 KRAS SHC1-1 LYN UBA52 CBL CSF1R STAT1 CSF1 SRC RPS27A PIK3CD UBB;UBC HCK PIK3CB PIK3R1 FYN DISEASES OF THE UREA CYCLE%REACTOME DATABASE ID RELEASE 97%9955698 Diseases of the urea cycle CPS1 ARG1 ASL ASS1 OTC NMRAL1 NAGS SLC25A15 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 DPH5 DPH6 DPH7 DNAJC24 DPH1 EEF2 DPH2 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 97%5083625 Defective GALNT3 causes HFTC MUC17 MUC5B MUC20 MUC21 MUC12 MUC15 MUC3A MUC5AC MUC1 MUC2 MUC7 MUC4 MUC6 GALNT3 MUC13 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) IDUA REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity BACH1 MAFK NFE2L2 HM13 HMOX1 SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339700 Signaling by TCF7L2 mutants CTBP2 CTBP1 TCF7L2 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism ACOT8 ELOVL1 SCP2 ELOVL2 ELOVL3 FADS2 ACSL1 HSD17B4 ABCD1 ELOVL5 ACAA1-1 FADS1 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 97%1280218 Adaptive Immune System CSNK2A1;CSNK2A3 STX4 SPOP MAF IRF4 STAT6 NFATC2 NFATC1 BATF IL4 PLCG1 PRKACA-1 ACTR1A PPP2R1A NEK2 MIB2 BTRC RBCK1 YWHAG SKP1 TCF7 CDC73 LEO1 FBXW11 UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 RPS27A UBB;UBC MAP3K8 DYNC1H1 REV1 MAD2L2 REV3L COLEC12 STAT3 CDH1 CTLA4 CR1L;CR1 CTSS CTSK BLK CTSD LAG3 CTSB PTPRJ CTSV;CTSL CD74 DAPP1 REL PTPN22 SIPA1 RAP1GAP2 NFKBIE FBXO32 ITGAL TRIM63 ITGA4 YAP1-1 E2F5 SMARCB1 STUB1 H2AC14 DPF1 DPF2 DPF3 SMARCC1 SMARCC2 WWTR1 YES1 PAXIP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP SS18L1 SMARCA2 SMARCA4 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 ASH2L RNF111 CD36 SS18 NCOA6 ACTL6A UBE2D3-1 ARF1 TEAD1 TEAD2 TEAD3 H2AJ TEAD4 PAX5 SUZ12 H2BC5 WWP1 H2BC1 EP300 H2AC4 KMT2D ERAP2 ERAP1 KMT2A TAP2 KMT2C TAP1 TAPBP ACTB-1 GSK3B DPY30 PAGR1 BCL7A H2BC21 BCL7C THEM4 BCL7B WDR5 EXOSC10 KDM6A TBP C1D EED MPHOSPH6 KCTD6 H2AZ2;H2AZ1 ARID1A ARID1B PIK3CD SMURF2 PIK3CG SMURF1 SMARCD1 CEBPA SMARCD2 SMARCD3 RBBP4 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 POLR2L SMARCE1 H2BC15;H2BC3;H2BC11;H2BC12 FGB FGA FGG AHCYL1 TLR1 S100A9 S100A8 TLR2 PIK3R3 PIK3R6 PIK3R5 CTSA CD4 PSMD12 PSMD11 PSMD14 PSMD13 LEF1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PAG1 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 RAF1 YWHAB AKT1 CD81 DIS3 YWHAZ EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 CR2 EXOSC3 EXOSC2 EXOSC1 RBX1 TREM2 GRAP2 KLRC4-KLRK1;KLRK1 KLRC4;KLRC3;KLRC2;KLRC1 TYROBP KLRD1 LCP2 PRKACB-1 KIF3A ITCH FKBP1A CD3G SYK HRAS FCGR3A;FCGR3B FYN FCGR1A CUL3 NRAS KBTBD7 MYD88 C3-1 NFKBIB CCNK CCNT1 PLCG2 SUPT16H GTF2F1 HMGB1-1 GTF2F2 NEDD4L AP1G1 SUPT4H1-1 AP1S2 AP1S1 AP1S3 AP1B1 SUPT5H CDK9 VAMP8 POLR2J;POLR2J2;POLR2J3 CCNT2-1 PTPRC TAF4B ELL ELOC-1 TAF7L ELOA AP1M2 NELFB MEF2B;BORCS8-MEF2B ELOB NELFCD AP1M1 NELFA NELFE SEC13 CTDP1 TAF9 POLR2A POLR2B POLR2C POLR2D SOCS1 POLR2G TAF9B ITPR1 POLR2I ITPR2 ITPR3 TAF15 PPP3R1 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TCEA1 TAF7 TAF6 PPP3CA TAF5 PPP3CB TAF4 TAF3 TAF2 TAF1 CHUK UBA7 HSPA5 UBE2L6 HERC5 IKBKB IKBKG CLTC CLTA LRR1 AP2A1 CCNF AP2B1 KEAP1 AP2A2 CBLB DCAF1 DNM1 HERC4 DNM2 HERC3 DNM3 AP2S1 RNF115 HERC2 SH3GL2 RNF114 HERC1 TRIM21 PPP2CB;PPP2CA FBXO7 FBXO9 PPP2R5B HERC6 PPP2R5A TRAIP-1 PPP2R5D WSB1 PPP2R5C FBXO2 RNF123 PPP2R1B RNF126 HECW2 PPP2R5E ANAPC13 UBE2J2 UBE2J1 RNF217 ATG7 TRIM11-1 HACE1 SIAH2 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 FBXL7 DZIP3 RNF220 DET1 LRSAM1 ITGB1 TRIM9 ARIH2 RNF144B GAN PRKN RNF130 INPP5D GPR75-ASB3;ASB3-1 HUWE1 KLHL2 KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 UBR2-2 LTN1 RNF19B UBE3A UBE3B ITK HLA-DPB1-1 UBE2Z FBXO21 HLA-DQB2;HLA-DQB1 FBXO22 CD3E CD3D NPEPPS HLA-DPA1 RNF19A MYLIP VASP FYB1 FBXW12 AREL1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 FBXW8 ENAH UBE2E3 HLA-DRA FBXO17 LAT UBE4A CD101 FBXO15 SEC61A2 UBE2E2 CD274 MRC2 SEC61A1 LMO7 FBXO10 PIK3R2 SEC61G FBXO11 PIK3CB SEC61B B3GNT3 PSME1 KLHL41 SEC22B KCTD7 PIK3R1 PSMB10 RNF41 PSMB8 KLHL42 PSMB9 UBE2V2 HIF1A CD207 CUL7 CUL5 UBA6 MYC UBA5 CUL2 UBR4 KLHL11 KLHL13 MYCN PIK3CA UBR1 FBXO44 PTPN6 FBXO41 TNRC6C MOV10 FBXO40 BTBD1 TNRC6A-1 AGO4 LONRF1 AGO2 UBE2F UBE2H UBE2B AGO3;AGO1 KLHL25 TNRC6B ZBTB16 GLMN CCND1 KLHL21 KLHL22 BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBOX5 UBE2U MKRN1 UBA3 RNF182 TPP2 UBE2O BLMH UBA1 UBE2K TRIM71 RNF14 KBTBD13 UFL1 UBE2Q1 UBE2Q2 UBE2D1 TRIM69 UNKL RELA ANAPC10 DTX3L PJA2 ANAPC11 PJA1 FZR1 CDC23 TRAF7 CDC26 UBE2R2 RNF138-1 CDC27 THOP1 TCF7L2 ANAPC7 RNF213-2 MGRN1 UBE2C ASB13 UBE2E1 ASB14 NFKB1 RNF6 ASB11 UBE2S RNF7 CDC16 ASB12 ANAPC4 ASB17 ANAPC5 RNF4 ANAPC1 RCHY1 ANAPC2 ASB18 FBXL22 ASB15 ICAM2 ASB16 IFI30 FBXL20 ZNRF1 BACH2 ZNRF2 ICAM1 HOXC4 HECTD1 SLAMF6 HECTD2 ASB10 SPTBN2 HECTD3 SH2D1A TRIM41 EAF1 EAF2 RNF25 IL21 FBXL19 TNFRSF13C FBXL18 CTSO FBXL15 AKT2 ACTR1B TRIM74;TRIM73;TRIM50 AKT3 CTSH FBXL16 CTSF FBXL13 CTSE FBXL14 CTSC FBXL12 B2M TRIM39 RELB HLA-DMA ASB8 HLA-DMB ASB9 APEX2 LNX1 ASB6 CD40LG TRIM36 CAPZA3 ACTR10 ASB7 TRIM37 CD84 ASB4 ATG14 LOC102723996;ICOSLG HLA-DOA ASB5 HLA-DOB ASB2 TRIM32 SUPT6H RPN2 SAR1B ZBTB17 ASB1 VCAM1 ITGB2 AFF4 RPN1 TNFSF13B PIK3R4 POLI POLH IRF8 DCTN6 DCTN5 DCTN4 MLLT1 MLLT3 IWS1 NFKB2 RILP MCM3AP SKP2 MAGT1 JAK1 RIPK2 RAP1B MAFK NFE2L2 BTLA TNFRSF14 CANX PPL TCF7L1 MYB STAT1 SEC24D-1 KIF5B KIF5A KIFAP3 KIF4B;KIF4A ATF3 VCP-1 KIF20A PDCD1LG2 MAP3K14 TUSC3 MAP3K7 KLC1 KLC4 KLC3 KLC2 RACGAP1 KIF3B TMEM258 KIF3C KIF18A UBE2V1 KIF11 KIF15 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CAPZB OST4 OSTC STT3A UBE2N KIF23 TAB2 KIF22 STT3B KIF2A BTNL9 BTN3A1;BTN3A3 BTN1A1 PDPK1 IRF1 BTNL2 BTN2A2;BTN2A1 DDOST KIF2C KIF2B DAD1 CDC42 TRAF6 PIK3C3 BECN1 CENPE SEC23A KIF26A CAPZA1 CAPZA2 VHL SEC24B SEC24A PTPN11 SEC24C AICDA CALM3;CALM1 RAB7A PAK2 FBXO4 FBXO6 FBXW4 PSME2 FBXW10;CDRT1 FBXW5 FBXW7 FBXW9 FBXW2 MYH9 FBXL3 FBXL5 PRKAB1 MAPKAP1 SEL1L JUN PRKAG1 RAC1 PRKAG3 RASGRP3 FOS PCNA EPAS1 NFATC3 PMS2 SOCS3 RICTOR STIM1 ORAI2 ORAI1 CDK4 MLH1 MSH2 ITGB5 ITGAV BCL6 PRR5 EXO1 MLST8 RFC5 RFC3 RFC4 RFC2 PRKAA1 RNF34 TRPC1 JUND E2F7 E2F8 MTOR LY96 FOSB CD14 TLR4 CDC34 PRKCQ CARD11 BCL10 RFC1 RASGRP2 RASGRP1 MALT1 LYN CD300LF;CD300LD UBE2D3;UBE2D2 ICAM3 NFKBIA ICAM4 ICAM5 TREM1 PVR SIGLEC10;SIGLEC11;SIGLEC16 ITGB7 LAIR1;LAIR2-1 CD96 PIANP CXADR SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 POLD3 LILRA5-4 OSCAR JAML CD8A POLD2 ULBP1-2 IFITM3;IFITM2;IFITM1 CD300E NCR3LG1-1 CD226 HCST RAP1A CLEC4G COPS5 NCR1-1 CD1D CD1C CD1B CD1A LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 SLAMF7 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 CD300LG CD99 KLRG1 NPDC1 SIGLEC5;SIGLEC14 SOS1 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L KLRB1-1 CD160 CRTAM SH2D1B PILRA;PILRB TREML1 SELL TREML4 TREML2 CDC20 SIGLEC1 RAET1E-1 NECTIN2 CD200 CD22 PRKAB2 LGMN PRKAG2 RAPGEF3 RAPGEF4 DERL2 RNF5 OS9 RNF185 PRKCB DYNC1LI1 DYNC1LI2 CD19 CD28 CD86 CD80 TRAT1 PIK3AP1 OSBPL1A LRRC41 PTEN VAMP3 MSH6 E2F2 PDCD1 PRKAA2 NCF1 CD8B;CD8B2 NCF2 NCF4 TRIB3 RAP1GAP WDR61 ICOS SNAP23 TIRAP CD33-1 NCK1 LCK EVL CD79B CD79A TLR6 CSK RBBP6 XDH BLNK BTK ERLIN1 ERLIN2 SH3RF1 CALR-1 S100A1 VAV1 CTNNBL1 WAS CTR9 RTF1 PAK1 SEC31A PAK3 PAF1 DYNC1I1 DERL3 DERL1 DCTN1 PPIA ERLEC1 CYBB CYBA MRC1 CSNK2A2 BRD4 CSNK2B CLEC4M;CD209-2 SH3KBP1 ZAP70 PDIA3 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins HPGD LTA4H ALOX5 ALOX15 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.5 Ovarian tumor domain proteases CDK1 TNFAIP3 DDX58 RIPK1 RHOA RNF135 IFIH1 OTUB2 OTUD5 TRIM25 OTUD7A VCPIP1 IKBKG MAVS TNIP3-2 ZRANB1 YOD1 RNF128 TNIP1 ESR1 UBA52 OTUB1 UBE2D1 OTUD3 PTEN VCP-1 RPS27A TRAF3 TRAF6 APC UBB;UBC TP53 NOD1 NOD2 RIPK2 TNIP2 OTUD7B INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement COLEC10 C1S C1R FCN2;FCN1 CFD C3-1 MASP1 CFB C2 MBL2-1 C1QC LOC110384692;C4A;C4B_2;C4B COLEC11 C1QB CRP MUSCLE CONTRACTION%REACTOME%R-HSA-397014.6 Muscle contraction ABCC9 VIM KCNK5 KCNK10 KCNK12 KCNJ14 KCNK13 KCNK15 KCNK16 KCNK18-1 KCNK17 KCNK2 CACNA2D2 KCNK4 KCNK6 KCNK7 KCNK1 AKAP9-1 PRKACA-1 TMOD3 ATP1B2 ATP1B1 KCND1 KCND2 KCNIP1 KCND3 KCNIP2 KCNIP4 FXYD4 FXYD3 GATA4 FXYD1 FXYD6 MYLK RYR1 RYR2 GUCY1A2 GUCY1A1 RYR3 GUCY1B1 CLIC2 TRDN ASPH MYL6 NOS1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 FKBP1B CACNA1G CACNA1I SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 ACTN2 PAK2 MYL4 ANXA2 MYL5 ITGA1 MYL7 MYL1 KCNQ1 SCN11A MYL2 SCN10A MYL3 MYL10 DMPK TPM4 MYLPF TPM3 KCNE1;KCNE1B MYL6B ANXA6 MYBPC3 CES1 MYBPC1 MYBPC2 TNNC1 TBX5 TNNC2 TNNT1 TNNT2 TNNT3 KCNA5 SORBS1 SORBS3 TCAP KCNH2 CACNB1 TMOD1 TMOD4 SCN1B TPM2 TPM1 SCN1A TMOD2 KCNJ2 KCNJ12;KCNJ18 TTN-1 KCNE2 KCNE3 KCNE4 KCNJ4 KCNE5 CALD1 CAV3 NEB FGF14 FGF13 FGF12 WWTR1 CACNA1H FGF11 TRIM72 MYL12A DYSF SCN3B LMOD1 SCN3A MYH3 MYH8 SCN2A MYH6 SCN2B CACNG6 TNNI1 TNNI2 TNNI3 DES RANGRF CACNB2 SCN9A NPPA SCN8A ITPR1 ITPR2 ITPR3 TLN1 SCN5A SCN4A SCN4B SCN7A CACNG7 NKX2-5 DMD KAT2B KCNJ11 MYL12B CACNG8 CACNG4 PXN STIM1 ORAI2 ORAI1 HIPK1 HIPK2 CACNA1C KCNK9 KCNK3 ITGB5 PAK1 KCNIP3 ACTN3 VCL MME NPR1 NPR2 NPPC CORIN CAMK2B TRPC1 CAMK2D CAMK2A CAMK2G MYH11 ANXA1 AHCYL1 ALDH2 PDE5A SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 97%166520 Signaling by NTRKs SOS1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IRS2 SHC2 RALGDS PTPRO ATF2 RALB MAPK13 RIT1 SGK1-1 RIT2 REST SRC SRF JUNB PLCG1 ADORA2A PTPRS GAB1 PPP2R1A MAPK7 MAP2K5 RAC1 TCF12 RHOA PCSK6 YWHAB CRK FOS NTRK1 CLTC CLTA NTRK3 AP2A1 AP2B1 NGF AP2A2 DNM1 DNM2 DNM3 NTF3 AP2S1 MAPKAPK2 DNAL4 SH3GL2 ID1 PPP2CB;PPP2CA EP300 PPP2R5D ATF1 ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 RPS6KA1 MEF2A MAPK14 MEF2C MAPK11 MAPKAPK3 ADCYAP1 ADCYAP1R1 MEF2D EGR1 STAT3 CDK5 DOCK3 GRIN2B CHD4 SH3GL3 ID4 IRS1 PIK3R2 PIK3CB HRAS PIK3R1 JUND NRAS TPH1 FRS2 PIK3CA PTPN11 BAX KIDINS220 FOSB PCSK5 SHC1-1 NTRK2 TIAM1 BDNF CDK5R1 F3 RALA-1 FURIN NAB1 NAB2 LYL1 ARC VGF TRIB1 SHC3 RRAD ASCL1 EGR2 EGR3 EGR4 FOSL1 MAP2K2;MAP2K1 RAP1A ID3 RAPGEF1 CDK5R2 ID2-1 MAPK1 BRAF NELFB MAPK3 CRKL MAPK12 FRS3 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9735869.2 SARS-CoV-1 modulates host translation machinery RPS14 HNRNPA1-1 RPS17 RPS16 RPS19 RPS18 EEF1A1 RPS11 RPS10 RPS13 RPS12 RPS27L RPS15A RPS3 RPS2 RPS4X RPS3A FAU RPS25 RPS27A RPS27 RPS29 RPS20 RPS21 RPS24 RPS9 RPS23 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 CA-DEPENDENT EVENTS%REACTOME%R-HSA-111996.3 Ca-dependent events PLA2G4A CAMK2G ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKCG PRKCD NBEA PRKCA CAMK4 PDE1C PRKAR2B CAMKK1 GRK2 CAMKK2 KPNA2 PRKX MAPK1 CAMK2B CAMK2D PDE1B PDE1A CAMK2A PRKACA-1 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375280 Amine ligand-binding receptors ADRA2C ADRA2A ADRA2B HRH1 CHRM3 HTR2B HTR2A DRD1 DRD2 DRD3 ADRA1D DRD4 ADRA1B DRD5 CHRM2 ADRA1A CHRM4 ADRB1 ADRB2 HTR4 HTR6 HTR7 HRH3 HRH2 HRH4 HTR1E TAAR8 GPR143 TAAR9 HTR1F TAAR6 HTR1D HTR1A CHRM1 TAAR5 HTR1B TAAR2 HTR5A TAAR1 ADRB3 CHRM5 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME%R-HSA-9823739.2 Formation of the anterior neural plate SOX1 ZEB2 ZIC2 POU5F1;POU5F1B OTX2 SOX2 POU3F1 ZNF521 PAX6 NANOG;NANOGP8 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor F8 VWF HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 97%162909 Host Interactions of HIV factors NUP133 RANGAP1 NUP50 POM121;POM121C NUP54 B2M CD4 NUP42 NUP43 PSMD12 PSMD11 PSMD14 RAE1 PSMD13 LCK RANBP2 RANBP1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 SLC25A5 PSMB2 NUP35 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RAN SLC25A6 ADRM1 NUP37 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 ARF1 PSMA1 PSMC4 PSMC1 SKP1 RAC1 ELMO1 XPO1 UBA52 AP2A1 AP2B1 NUP214 AP2A2 AP2S1 RPS27A UBB;UBC RBX1 CD28 NPM1-2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E KPNB1 PSIP1 DOCK2 PPIA HCK FYN CUL5 SLC25A4 NUP107 NUP188 CCNT1 RCC1 BANF1 KPNA1 NUP210 ATP6V1H NUP93 NUP205 AAAS NUP160 PAK2 NUP85 TPR NUP88 AP1G1 AP1S2 CD8B;CD8B2 AP1S1 NUP155 AP1S3 AP1B1 NUP153 CDK9 ELOC-1 PACS1 NUP62 AP1M2 ELOB AP1M1 NDC1 SEC13 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis POLR2I DICER1 AGO4 AGO2 AGO3;AGO1 POLR2J;POLR2J2;POLR2J3 POLR2E POLR2F POLR2H POLR2L RAN POLR2A POLR2B POLR2C BCDIN3D TARBP2 POLR2D PRKRA XPO5 DGCR8 DROSHA POLR2G UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%R-HSA-5210891.4 Uptake and function of anthrax toxins PDCD6IP CALM3;CALM1 MAP2K2;MAP2K1 FURIN MAP2K4 MAP2K7 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111461.5 Cytochrome c-mediated apoptotic response APAF1 UACA AVEN CASP3 DIABLO-1 CASP9 MAPK1 CASP7 MAPK3 CYCS-1 APIP XIAP DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema KLKB1 SERPING1 F12 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 BRCA2 RAD51AP1 DNA2 XRCC2 PALB2 BRIP1 MRE11 NBN BARD1 RBBP8 SEM1 POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764790 Positive Regulation of CDH1 Gene Transcription KLF4 FOXA2 STRAP FOXP2 RB1 ZEB2 TFAP2A FOXJ2 ARID1A KLF9 SP1 SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR PLA2G4A GNA13 AKT2 AKT3 MGLL TAS2R3-1 S1PR1 PDE3B TAS2R16 DRD1 CCL3L1;CCL3L3;CCL3;CCL18 DRD2 DRD3 DRD4 DRD5 POMC TAS2R40 TAS2R41 APP TAS2R39 ADORA2A EGFR ADORA3 ADORA1 PRKACA-1 PPP2R1A PRKCE TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 WNT3A PRKAR2B PRH1-TAS2R14;TAS2R14-3 RPS6KA3 KPNA2 RPS6KA2 RPS6KA1 TIAM2 PDE1B PDE1A PDE2A PDE11A PDE10A LHB TAS2R7 TAS2R8 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW GRM4 TAS2R1 TAS2R4 PDPK1 CAMKK1 CAMKK2 C3AR1 TAS1R2 TAS1R1 CDC42 TAS1R3 CALM3;CALM1 MMP3 GNAL GNGT1 NBEA RGS9 ITGA5 RGS6 RGS7 GLP1R SST GNA14 GNG10 RAMP2 GABBR2 GNA15 GNG2 GABBR1 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ IHH GNB2 GNB1 ADM IAPP GNB4 CHRM2 GNB3 CHRM4 ADRB1 ADRB2 GNB5 HTR4 RGS11 HTR6 HTR7 HRH3 HRH2 CALCRL HRH4 HTR1E TAAR8 TAAR9 MCHR1 HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 ADRB3 SCT RXFP4 MRGPRD FZD10 RXFP1 MAPK7 RXFP2 RXFP3 CRHBP GPR176 CMKLR1 AGTR2 FPR1 SSTR3 GHRHR GALR3 GALR2 GALR1 NPBWR1 RHOA NPBWR2 WNT10B WNT10A GPR15 FZD9 GPR183 PNOC MC4R GPR18 GPR27 EDNRB GPR25 HBEGF RHO GPR20 PTH1R EDN1 UCN3 EDN3 GPR37 GPR35 GPR32 PTH2R RGR MC3R PLPPR1 PLPPR2 GPR45 PLPPR3 MC1R PLPPR4 MC5R PLPPR5 WNT8A WNT8B NPFFR2 GPR150 NPFFR1 P2RY12 NPFF HCRT P2RY13 PF4;PF4V1-1 P2RY14 QRFPR WNT7B QRFP GPR55 HCRTR2 SCTR HCRTR1 WNT7A ADM2 MTNR1A MTNR1B GPR83 GPR84 CALCB;CALCA RLN3 ECE1 PRLHR INSL3 INSL5 P2RY4 ADCYAP1 APLN ECE2;EEF1AKMT4-ECE2 ADCYAP1R1 VIPR1 VIPR2 RRH PTGDR GPR37L1 KEL TAS2R42 ADRA2B GIPR CRHR1 NLN PENK PPY CDK5 PPP1R1B CRH PDE3A PTGDR2 NPY4R2;NPY4R PPP3CC OXGR1 GPBAR1 GAL OPRD1 PTGER4 NPB RAMP3 PTH PTGER2 PTGER3 NPW RLN2;RLN1 PRLH MAS1 XK GHRH HCAR1 HCAR2;HCAR3 RAMP1 NPY2R NPY RGS8 CAMK4 PDE8B PDE8A NPY1R PCP2 APLNR SUCNR1 WNT6 GRK3 CALCR GRK6 WNT2 WNT3 PIK3CG OPN3 OXTR PDE4D-1 RGSL1 PTCH2 GRPR OPN5 TRPC7 EDNRA PYY PROK2 GPSM1 PROK1 GPSM2 TRPC6 UTS2R WNT2B PRKCH TRPC3 ADGRE1 TRHR GRM3 OPRM1 UTS2B HEBP1 CAMK2B AGTR1 GRM2 CAMK2D PTGFR ADGRE5 CAMK2A LPAR1 GRM7 LPAR2 GRM6 CXCL12 LPAR3 GPER1 FPR2 ADGRE3 LPAR4 GRM8 CAMK2G NTSR1 PDE4A NTSR2 GPSM3 GPR17 PTGIR NMB NPY5R XCR1 PDE4C OPRK1 XCL1;XCL2 GLP2R NMBR SSTR1 LPAR5 SSTR2 LPAR6 WNT16 NMS SSTR4 NMU SSTR5 GNRH1 RGS14 MLN OPRL1 BRS3 PTHLH GPRC6A CNR2 GPR132 CNR1 CCKAR RGS20 GNRHR S1PR3 PRKCQ FFAR4 RGS22 FFAR2 S1PR2 GAST S1PR5 GPR39 RASGRP2 S1PR4 EDN2 RASGRP1 RGS10 ANXA1 RGS12 TACR2 PDE7B TACR3 ACKR1 TACR1 VIP CCKBR PDE7A NPSR1 GRP F2R TIAM1 PTGER1 F2 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 KNG1 F2RL1 F2RL2 CCR6 F2RL3 DGKG DGKE CHRM1 AHCYL1 DGKD CCR2 GPR68 DGKB GPR65 DGKA PRKX MAPK1 CHRM5 PMCH MAPK3 ABHD12 RGS4 RGS5 RGS2 RGS3 RGS1 GHSR CASR DGKZ SOS1 LTB4R2 DGKQ DGKK DGKI DGKH PIK3R3 ABHD6 PIK3R6 NTS PIK3R5 MCHR2 HRH1 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2A TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 DAGLB RGS18 RGS17 RGS19 RGS13 CALCA RGS16 P2RY6 P2RY2 P2RY1 RGS21 CCK KISS1 FFAR3;GPR42 PDE1C GRK2 GIP ROCK1 GCGR PPP1CA PLEKHG5 AKT1 C5AR2 PRKCD PRKCA C5AR1 C5 TRIO CD55 ITSN1 PREX1 PRKCB NGEF GNAS-1 ADCY9 SMO PRKAR1B PRKAR1A ABR ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A ADRA1D PTCH1 ADRA1B ADRA1A TBXA2R GNA12 FSHB ARHGEF33 ARHGEF37 ARHGEF38 CRHR2 SHH CYSLTR1 CYSLTR2 GNAT3 ADORA2B GNAZ HRAS GNAI3 FGD1 FGD2 FGD3 OPN1SW FGD4 NRAS C3-1 SAA2;SAA1 MCF2 MC2R ARRB1 PLCB3 PLCB4 PLCB1 PLCB2 CCR5 WNT9A AGT CHRM3 PLXNB1 AVPR2 RASGRF2 CXCR4 GNAT2 PLEKHG2 PRKCG ITPR1 ITPR2 WNT5A ITPR3 PPP3R1 WNT1 FZD1 SOS2 FZD3 ROCK2 FZD2 SRC FZD5 FZD4 FZD7 PSAP FZD6 FZD8 ARRB2 PPP3CA PPP3CB GNAI1 GNAI2 GCG CXCL9 ADRA2C CXCL8 CXCL13 ADRA2A CX3CL1 CCRL2 CCR9 CXCL5;CXCL6 CCR8 CCR7 BTK CCR4 CCR3 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 KALRN CXCR1 CXCR3 CCL5 CXCR2 CCL1 CCL19 DHH CCL17 CCR10 CCL16 CCR1 NET1 CCL25 CCL22 CCL21 CCL20 PPBP CXCL10 CXCL11 AKAP13 ACKR4 ACKR2 CCL28 CCL27 ACKR3-2 PPP2CB;PPP2CA VAV3 PPP2R5D LHCGR PPP2R1B FSHR GPHA2 RHOC TSHR GPHB5 VAV1 VAV2 RHOB ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 ARHGEF5 GNAT1 ITGB1 ARHGEF6 PAK1 WNT11 WNT4 WNT9B PDYN FFAR1 PIK3R2 ARHGEF40 PIK3R1 CENPS-CORT;CORT;CENPS ARHGEF26 ARHGEF25 PIK3CA CGA ECT2 ARHGEF39 CX3CR1 ARHGEF10L MCF2L ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 AVPR1B ARHGEF19 ARHGEF18 AVPR1A AVP TSHB CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 97%9840373 Cellular response to mitochondrial stress DELE1 EIF2AK1 STOML2 PHB2 EIF2S2 EIF2S3;EIF2S3B YME1L1 OMA1 EIF2S1 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME%R-HSA-5579030.4 Defective CYP19A1 causes AEXS CYP19A1 PRPP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%73843 PRPP biosynthesis PRPS2 PRPS1 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 97%444257 RSK activation RPS6KA3 RPS6KA2 RPS6KA1 RPS6KA6 MAPK1 PDPK1 MAPK3 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 97%3928662 EPHB-mediated forward signaling ARHGEF28 ARPC4 ARPC5 LIMK2 ARPC2 LIMK1 ARPC3 PAK1 RAC1 YES1 ACTB-1 RHOA GRIN2B KALRN GRIN1 CFL1 SDC2 LYN ACTR2 PTK2 ARPC1B ARPC1A TIAM1 ACTR3-1 WASL ROCK2 ACTG1 CDC42 ITSN1 HRAS FYN RASA1 ROCK1 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.3 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis LPL MED30 PDK4 ABL1 MED1 ACSL1 CDK8 MGLL MED4 CDK5 MED6 MED7 AGPAT2 PAXIP1 PEX11A CCNC-1 DPY30 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PAGR1 PPARGC1B CREBBP H2BC21 CIDEC WDR5 RXRA KDM6A GPAM H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 LPIN1 ASH2L MED16 PNPLA2 MED17 MED12 MED14 MED13 MED10 CD36 CEBPA NCOA1 NCOA2 ACSS3 NCOA6 ELOVL5 NCOA3 HDAC3 DGAT2 MED27 SIRT1 MED23 NCOR2 RBBP5 H2AJ NR5A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 MED24 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 AJUBA SCD H2BC1 THRSP FABP4 MED31-1 EP300 PHLDA1 H2AC4 ADIPOQ TBL1XR1 RB1 KMT2D KMT2C LIPE H2AC14 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME%R-HSA-9690406.3 Transcriptional regulation of testis differentiation SRY NR5A1 GATA4 SOX9 PTGDS DHH WT1 FGF9 AMH DMRT1 ZFPM2 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX5 ALOX15 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME%R-HSA-9661070.2 Defective translocation of RB1 mutants to the nucleus RB1 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 97%8949613 Cristae formation ATP5F1A APOO ATP5F1B APOOL MTX2 ATP5F1C SAMM50 ATP5F1D CHCHD3 CHCHD6 ATP5MJ ATP5MG ATP5ME DNAJC11 ATP5MC2 TMEM11 ATP5MC3 MTX1 IMMT ATP5MC1 HSPA9 ATP5PF ATP5PD ATP5PB MICOS13 MICOS10 DMAC2L ATP5PO IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 RIPK3 UBE2D1 UBE2V1 TICAM2 UBE2D3-1 LY96 BIRC2 CHUK TICAM1 BIRC3 RPS27A RIPK1 TRAF6 CD14 UBB;UBC TLR4 IKBKB IKBKG UBE2N UBE2D3;UBE2D2 UBA52 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs NCBP1 SNRPE-2 LSM10 ZNF473 LSM11 SNRPF SNRPB SNRPD3 NCBP2-1 SNRPG-2 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME DATABASE ID RELEASE 97%175567 Integration of viral DNA into host genomic DNA PSIP1 BANF1 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 97%9918485 Dengue Virus Attachment and Entry MRC1 MERTK TIMD4 UBA7 HSPA5 CD14 CLDN1 CD33-1 GPC1 SDC4 PROS1 UBA3 GPC3 SDC2 GPC2 SDC3 GPC5 UBA1 AP2A1 GPC4 AP2B1 HSPG2 AP2A2 GPC6 CLEC4M;CD209-2 FURIN AP2S1 AGRN SDC1 EMC4 MAPRE3 PIK3R1 ATG7 LY6E RPSA AXL TYRO3 UBA6 UBA5 GAS6 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 97%5362798 Release of Hh-Np from the secreting cell DISP2 SCUBE2 ADAM17 NOTUM DHH IHH GPC5 SHH APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B CDK1 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CCNB1 ANAPC11 CDC23 CDC20 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 UBA52 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME%R-HSA-9819196.1 Zygotic genome activation (ZGA) DUXB DPPA4 DPPA2 LEUTX YAP1-1 DUX4;DUXA TEAD4 EP300 TPRX1;RAX2 TP53 ZSCAN4 CREBBP TUT7 TUT4 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%381340 Transcriptional regulation of white adipocyte differentiation LPL MED30 MED13L HELZ2 FAM120B MED1 CDK8 MED4 MED6 MED7 TNF KLF4 CEBPD EBF1 CCNC-1 PPARGC1A TGS1 CREBBP CCND3 SREBF2 RXRA WNT1 CARM1 PPARG PPARA LEP MED16 MED17 NR2F2 MED12 MED14 MED13 MED10 MED8 CD36 MED9 CEBPA NCOA1 NCOA2 MED19 NCOA6 SMARCD3 MED15 NCOA3 HDAC3 MED18 MED11 MED27 MED23 NCOR2 TGFB1 NCOR1 MED26 MED24 CDK19 MED29 WNT10B MED22 MED20 MED25 ANGPTL4 PLIN1 MED21 CEBPB ADIRF SLC2A4 ZNF638 RELA FABP4 ZNF467 CDK4 KLF5 MED31-1 CHD9 EP300 MED28-1 EGR2 NFKB1 ADIPOQ TBL1XR1 PCK1 THRAP3 ALANINE METABOLISM%REACTOME%R-HSA-8964540.4 Alanine metabolism GPT TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation PSEN2 TGFBR3 APH1A TIMP2 APH1B TIMP1 MMP14 PSEN1 MMP16 PSENEN NCSTN DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V GP1BA GP5 GP9 VWF GP1BB TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism FABP3 FABP5 PPP1CA FABP6 PNPLA4 ABHD5 FABP4 FABP7 PNPLA5 PLIN3 MGLL GPD2 PPP1CC FABP12 CAV1 PLIN1 PRKACB-1 FABP9 FABP1 PPP1CB FABP2 LIPE PRKACA-1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) NCF1 NCF2 NCF4 CYBB CYBA ITGB5 CD36 ITGAV SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 97%111469 SMAC, XIAP-regulated apoptotic response APAF1 CASP3 DIABLO-1 CASP9 CASP7 CYCS-1 XIAP THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2514856 The phototransduction cascade METAP1 GNAT1 METAP2 FNTB;CHURC1-FNTB GUCY2D PPEF1 CALM3;CALM1 PRKCQ CNGB1 RHO GNB1 CNGA1 SLC24A1 SAG GNGT1 PRKCA CAMKMT RGS9BP NMT1 LOC118142757;GUCA1A NMT2 GRK1 FNTA PDE6B GRK7 PDE6A RCVRN GUCA1C BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9024909 BDNF activates NTRK2 (TRKB) signaling BDNF NTRK2 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME DATABASE ID RELEASE 97%2206291 MPS IIIC - Sanfilippo syndrome C HGSNAT RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 BRCA2 RAD51AP1 DNA2 XRCC2 XRCC3 PALB2 BRIP1 MRE11 NBN BARD1 RBBP8 RTEL1 SEM1 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection B2M CD4 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SLC25A5 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 SLC25A6 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 XPO1 UBA52 NUP214 RPS27A UBB;UBC CD28 RBX1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E DOCK2 HCK FYN CCNK NUP107 NUP188 CCNT1 GTF2B RCC1 BANF1 KPNA1 SUPT16H NUP210 LIG1 LIG4 GTF2F1 GTF2F2 ATP6V1H NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 TSG101 NEDD4L AAAS GTF2E1 GTF2E2 PAK2 NUP160 NUP85 TPR NUP88 AP1G1 SUPT4H1-1 AP1S2 XRCC6 CD8B;CD8B2 AP1S1 NUP155 AP1S3 XRCC4 FURIN XRCC5 VTA1 AP1B1 NUP153 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 CHMP2A NMT2 TAF4B FEN1 ELL ELOC-1 TAF7L NUP62 ELOA AP1M2 NELFB ELOB CCNH NELFCD AP1M1 NELFA CCR5 NELFE NDC1 SEC13 PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 POLR2A NUP42 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B POLR2I RAE1 RANBP2 LCK RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 UBAP1 NUP35 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 ARF1 RAC1 ELMO1 AP2A1 AP2B1 AP2A2 GTF2H1 GTF2H3 GTF2H4 AP2S1 NPM1-2 CDK7 MNAT1 KPNB1 PSIP1 TBP PPIA GTF2H2C;GTF2H2C_2;GTF2H2 CUL5 SLC25A4 POLR2E POLR2F POLR2H POLR2L ERCC3 ERCC2 PACS1 IMMUNE SYSTEM%REACTOME%R-HSA-168256.9 Immune System GBP2;GBP3;GBP1 S1PR1 SERPINB1 STX4 SPOP DTX4 TTR RAB14 VAPA REV1 MAD2L2 REV3L COLEC12 COLEC11 HSP90B1 TXN PRKDC DERA APEH IL9 IL9R PTGES2 ALOX15 DDX41 IDH1 TBC1D10C HK3 RAB31 PDXK NOS3 TRAPPC1 ALDH3B2;ALDH3B1 RAB27A GDI2 IQGAP1 CYB5R3 RAB10 RAB18 ARF1 RPLP0 ECSIT PGAM1 TNFSF11 VAMP2 DBNL GSN ERAP2 ERAP1 TAP2 TAP1 TAPBP CRCP POLR3GL POLR3A POLR3B POLR3C FABP5 POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K KPNB1 HSPA2 THEM4 EXOSC10 C1D MPHOSPH6 MME PIK3CD PIK3CG FPR2 ANXA1 PTAFR AHCYL1 ARSA STX1A PIK3R3 PIK3R6 PIK3R5 CTSA WASL LAT2 ACAA1-1 AAMP PAG1 C1QB CPB2 CD81 C1R C5AR2 CFI C5AR1 C8B C8A CPN2 C2 CPN1 C5 C8G C6 C7 C9 CD59 CD55 CR2 CFHR1;CFHR2 CFH-3 C1QC PKM ZEB1 PNP-1 SAMHD1 TREM2 GRAP2 KLRC4-KLRK1;KLRK1 KLRC4;KLRC3;KLRC2;KLRC1 TYROBP KLRD1 LCP2 CTSZ ANPEP ATP6AP2 EBI3 IL27 IL6ST CRLF1 IL27RA PLCG2 SP100 CNPY3 SIGIRR IRAK3 MLEC PTPRC ASAH1 MEF2B;BORCS8-MEF2B MAPK12 AOC1 PTPN18 GYG1 AIP ITPR1 DUS2 ITPR2 ITPR3 FAAP24 PSAP LOC105377022;FANCB FAAP100 CENPX FANCM FANCL FANCA FANCE FANCG FANCF GM2A CXCL8 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 PTPN13 CCL4L2;CCL4L1;CCL4 PFKL CXCR1 IMPDH1 CCL5 IMPDH2 CXCR2 CCL19 CCR1 CCL22 CCL20 PPBP CXCL10 ILF3 MAOA MGST1 NDUFC2;NDUFC2-KCTD14 INPP5D GLIPR1 ITK HLA-DPB1-1 HLA-DQB2;HLA-DQB1 CD3E CD3D HLA-DPA1 MANBA VASP NME2 FYB1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ENAH HLA-DRA AMPD3 LAT CD101 SEC61A2 MRC2 SEC61A1 SEC61G SEC61B B3GNT3 PSME1 SEC22B ALDOC PSMB10 PSMB8 ALDOA PSMB9 CD207 DNAJC5 HSPA9 MAN2B1 NAPRT SLC15A4 SLC2A5 ICAM2 IFI30 BACH2 ICAM1 HOXC4 SLAMF6 SPTBN2 SH2D1A EAF1 EAF2 IL21 TNFRSF13C CTSO ACTR1B CTSH CTSF CTSE CTSC RELB HLA-DMA HLA-DMB APEX2 CD40LG CAPZA3 ACTR10 CD84 LOC102723996;ICOSLG HLA-DOA HLA-DOB SUPT6H ZBTB17 VCAM1 ITGB2 AFF4 TNFSF13B POLI POMC POLH IRF8 DCTN6 DCTN5 DCTN4 MLLT1 APP MLLT3 NLRC4 MEFV IWS1 RILP NFKB2 PANX1 MCM3AP PYCARD P2RX7 PSTPIP1 AIM2 CASP1 TXNIP NLRP1 SUGT1 ATG12-1 SKP2 ATG5 RAP1B HGF MAFK NFE2L2 BTLA TNFRSF14 HSPA1L HSPA6 EEF1A1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 EEF2 TCF7L1 SOX2 MYB KIF5B KIF5A KIFAP3 KIF4B;KIF4A ATF3 PDCD1LG2 KIF20A MAP3K14 EDA TNFRSF13B EDA2R TNFRSF8 TNFRSF4 EDARADD TNFRSF12A TNFRSF1B KLC1 EDAR LTA TNFRSF25 KLC4 LTB KLC3 TNFRSF11B KLC2 RACGAP1 TNFRSF11A TNFRSF17 KIF3B TNFSF18 TNFSF14 KIF3C CD70 TNFSF15 TNFRSF9 TNFSF4 TNFSF9 KIF18A CD27 TNFSF8 LTBR KIF11 KIF15 IST1 CAPZB JAK2 KIF23 KIF22 RBSN KIF2A BTNL9 BTN3A1;BTN3A3 BTN1A1 IRF1 BTNL2 IRF2 BTN2A2;BTN2A1 IL23R KIF2C IL23A KIF2B DOCK2 HBD;HBB CDC42 SH2B3 CENPE KIF26A CAPZA1 CAPZA2 MGAM CHIT1 EIF2S2 EIF2S3;EIF2S3B EIF2S1 NOS2 ATP6V1H RAB7A PITPNA LMNB1 CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 PAK2 IL12RB2 IL10 SERPINB2 ANXA2 MSN MIF RALA-1 SOD2 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 LCP1 MT2A DUSP4 DUSP3 VRK3 DUSP6 DUSP7 MYH9 ATF2 PRDX6 PRKAB1 MAPKAP1 PECAM1 CDK13 CDKN1A PRKAG1 PRKAG3 CASP10 RASGRP3 FOS PCNA NFATC3 PMS2 RICTOR STIM1 P2RX1 ORAI2 ORAI1 MLH1 LAMTOR2 LAMTOR1 LAMTOR3 MRE11 MSH2 NPM1-2 MAP2K6 FCER2 FANCC BCL6 IL21R PIN1 PRR5 EXO1 MLST8 CASP2 COMMD9 RFC5 RFC3 RFC4 COMMD3 APAF1 RFC2 BIRC5 PRKAA1 SOCS6 RNF34 SOCS5 E2F7 E2F8 PML MTOR CAND1 TLR3 PADI2 CD300LF;CD300LD ICAM3 ICAM4 ICAM5 TREM1 PVR SIGLEC10;SIGLEC11;SIGLEC16 ITGB7 LAIR1;LAIR2-1 CD96 PIANP CXADR SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 LILRA5-4 OSCAR JAML CD8A ULBP1-2 IFITM3;IFITM2;IFITM1 CD300E NCR3LG1-1 CD226 HCST CLEC4G NCR1-1 CD1D CD1C CD1B CD1A LILRA4;LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5;LILRA6 SLAMF7 LOC102725035;LOC107987425;LILRB3;LOC112268337;LOC107987441;LOC112268340;LOC112268336;LOC112268334;LOC107987462;LILRB5 CD300LG CD99 KLRG1 NPDC1 SIGLEC5;SIGLEC14 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L KLRB1-1 CD160 CRTAM SH2D1B PILRA;PILRB TREML1 SELL TREML4 TREML2 SIGLEC1 RAET1E-1 NECTIN2 CD200 CD22 BRWD1 CST3 SNCA TSPAN14 ROCK1 MUC13 DSP CD47 CKAP4 SIRPA;SIRPB1;SIRPG DSG1 SIRPB1 LBP CYFIP2 CYFIP1 NCKAP1 CD180 LY86 WASF1-1 ITGAM EEA1 WIPF1 TASL WIPF2 IRF5 WIPF3 PRKCB DYNC1LI1 DYNC1LI2 IQGAP2 NCKAP1L JUP ARHGAP9 ARPC1B ARPC1A LRRC41 VAMP3 NCAM1 FLNA SERPINA1 ABI2 ABI1 NCF1 NCF2 NCF4 STK10 RAP1GAP NFASC ABL2 ARPC4 ARPC5 ARPC2 ARPC3 NF2 SNAP23 CAP1 NCK1 ACTR2 LCK EVL SOS2 SRC CSK RBBP6 WASF2 WASF3 BAIAP2 BTK DSN1 PTK2 FAF2 ITGAX SH3RF1 C1QBP STBD1 SPTAN1 VAV3 RHOG RHOF IFI16 VAV1 NLRP4 VAV2 TREX1 ADAR RHOU WAS PAK1 PAK3 DYNC1I1 MYO9B UBE2I RORA PIAS1 RAB9B SUMO1 ACTG1 PPIA ARG1 TP53 CYBB CYBA ARHGAP45 PLA2G2A-1 CENPS-CORT;CORT;CENPS CPNE3 DGAT1 CSNK2A2 NCKIPSD CSNK2B PLD4 DIAPH1 PLD1 PLA2G6 PLD3 PLD2 ACTR3-1 SLC44A2 LPCAT1 ZAP70 MOSPD2 STOM PTK2B LIMK1 CSNK2A1;CSNK2A3 AGPAT2 VIM TNF IL4R IL13 MAF IRF4 CCL3L1;CCL3L3;CCL3;CCL18 STAT6 STAT5A STAT5B POU2F1 NFATC2 NFATC1 BATF IL4 IL5 PLCG1 PRKACA-1 ACTR1A TNFAIP3 PPP2R1A NEK2 MIB2 TNFRSF1A BTRC CEP290 CYLD RBCK1 YWHAG BIRC2 SKP1 BIRC3 TCF7 HSP90AA1 CDC73 OPTN-1 LEO1 FBXW11 UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 TANK CSF1 FUCA1 ATF1 RPS27A ELK1 RPS6KA3 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K8 MEF2A DYNC1H1 MAP2K3 MAP2K4 MEF2C MAPKAPK3 MAPK9 TUBB4B MAPK8 MAP2K7 TUBB4A;TUBB;TUBB8B;TUBB8 MAPK10 TNIP2 CDK1 BCL2L11 STAT3 BCL2 BCL2L1 CDH1 COL1A2 CAPN1 CTLA4 ADAM10 ADAM17 ADAM8 CR1L;CR1 PSEN1 NCSTN A2M ELANE PLAUR RORC PLAU HRG CTSS SERPINB6-2 MMP25 PAFAH1B2 CTSK CASP3 TIMP2 CTSG BLK TIMP1 PTPN7 IL34 CTSD GAB3 LAG3 CTSB CTSV;CTSL FOXO3 PTPRJ CD74 DAPP1 MMP1 REL MMP2 PTPN22 SIPA1 MMP3 MMP8 RAP1GAP2 MMP9 NFKBIE OTUD5 FBXO32 ITGAL CRP CD44 COLEC10 FCN2;FCN1 LAMA5 TRIM63 ITGA4 TNFRSF18 FURIN YAP1-1 E2F5 PRSS3;PRSS2;PRSS1 IL2RA KLKB1 SMARCB1 STUB1 PTPN4 LGALS3 H2AC14 DPF1 DPF2 DPF3 SMARCC1 SMARCC2 WWTR1 YES1 PAXIP1 FOXO1-1 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP MAPK13 SS18L1 SMARCA2 SMAD2;SMAD3 SMARCA4 IL2 IL3 H2AC20 H2AB2;H2AB3;H2AB1 EZH2 CAT RETN ASH2L JUNB RNF111 CD36 TARBP2 SS18 PRKRA NCOA6 ACTL6A UBE2D3-1 TEAD1 TEAD2 TEAD3 FPR1 H2AJ TEAD4 PAX5 SUZ12 H2BC5 WWP1 H2BC1 CSF2 EP300 H2AC4 GPR84 KMT2D KMT2A KMT2C ABL1 ACTB-1 GSK3B OPRD1 DPY30 PAGR1 BCL7A H2BC21 BCL7C BCL7B WDR5 KDM6A TBP EED LIFR H2AZ2;H2AZ1 KCTD6 ARID1A ARID1B SMURF2 POLR1C SMURF1 POLR1D SMAD7 SMARCD1 CEBPA YBX1 OPRM1 SMARCD2 CAMK2B CAMK2D ADGRE5 CAMK2A SMARCD3 ADGRE3 CAMK2G RBBP4 RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 POLR2L SMARCE1 PROS1 F13A1 H2BC15;H2BC3;H2BC11;H2BC12 CD177 FGB FGA FGG F2 EPPIN;EPPIN-WFDC6 PGLYRP4 PGLYRP3 PGLYRP2 LEAP2 LYZ-1 GMFG DEFB1 SERPING1 SLA2 CLU MCEMP1 DEFB109B KNG1 RNF216 BPIFA1 HP;HPR REG3G;REG3A-1 TSLP CCR6 F12 FUCA2 ATP7A PGLYRP1 IL31RA IL18BP CAMP OLR1 CCR2 IFNL2;IFNL3;IFNL1 DEFB131B;DEFB131A EIF2AK2 STX3 DEFB119 YPEL5 DEFA6;DEFA4;DEFA5 CRLF2 DEFB118 SLA DEFB116 TOM1 SLC11A1 ARL8A DEFB114 GBP5-1 RNASE6 NIT2 DEFB110 CIITA TLR1 TRIM68 RNASE3;RNASE2-2 ACP3 BPI SNAP29 S100A9 TRIM62 S100A8 TRIM22;TRIM34;TRIM6-TRIM34 LTF RNASET2 TLR2 TMBIM1 DEFB129 TRIM56 DEFB128 CANT1 DEFB127 DEFB106B;DEFB106A TRIM46 MUC12 TRIM45 DEFB125 IL2RB MUC15 DEFB123 TRIM35 DEFB121 TRIM38 ART1 TRIM31 ITLN2;ITLN1-2 IL36A PDZD11 MUC3A MUC5AC IL36B RNASE7 TRIM29 CHGA TRIM26 DEFB135 DEFB107A;DEFB107B C6orf120 METTL7A-1 CFP S100A7A;S100A7 SLPI DEFB132 CRISPLD2 ATOX1 DEFB130B;DEFB130A TRIM14 TRIM10 DEFB105A;DEFB105B TMEM63A CD4 SYNGR1 BPIFB2 IL36G MUC1 BPIFB1 NBEAL2 MUC2 BPIFB4 IL1F10 BPIFB6 LCN2 IL20 IL25 MUC7 DEFB103A;DEFB103B IL26 DEFB4A;DEFB4B MUC4 IL24 MUC6 FCER1A PSMD12 IL11 MUC17 FCER1G PSMD11 IL15 MUC5B PSMD14 IL19 MUC20 PSMD13 IL16 MUC21 LEF1 RAP2B TAX1BP1 CAB39 DNAJC3-1 PSMA7 C1orf35 PGGT1B PSMD8 MAP3K3 IL31 PSMB6 GCA PSMB7 IL37 PSMD6 OSM PSMB4 IL18R1 PSMD7 SRP14 PSMB5 ENPP4 PSMB2 RAG2 PSMB3 RAG1 PSMD2 IRAG2 PSMD3 ADGRG3 PSMB1 IL36RN PSMD1 GGH IFIT1 ADA2 IFIT3 IL7R IFIT2 ADRM1 MS4A3 TNFAIP6 CHI3L1 PSMC2-1 MS4A2 PSMA2-1 IL1RL2 PSMA5 ATP8A1 TEC SEM1 PTX3 PSMA6 CNTF PSMC5 FRMPD3 PSMA3 MX1-1 PSMC6 TOLLIP PSMA4 ATP6V1E1 AHSG ATP6V1E2 PLEKHO2 PSMC3 ATP6V1G1 GRN PSMA1 ATP6V1G2 IL10RB PSMC4 CLCF1 PSMC1 ATP11B CSF3 CTNNB1 TMEM179B ATP11A RAB3D IL5RA RAB44 LAMP1 LAMP2 IL13RA2 IL13RA1 KCMF1 ILF2 RAF1 RAB37 RAB4B ATP6V0D1 FGL2 ATP6V0D2 YWHAB HSPA1A;HSPA1B RAB24 ATP6V1A CPPED1 IL1RN IFIT5 IL1R2 KRT1 AKT1 TXK STXBP2 NUP214 ATP6V0A2 VAT1 DIS3 LIF PRKCD ATP6V0A4 CSTB SVIP QPCT YWHAZ ATP6V1D COTL1 ATP6V1C1 IL11RA MAPKAPK2 COPB1 ATP6V1F ATP6V0A1 LPO OASL EXOSC7 ATP6V1C2 OAS1 EXOSC6 OAS3 EXOSC5 ATP8B4 CLEC12A EXOSC4 TMEM30A SCAMP1 EXOSC9 SERPINB3;SERPINB4-1 EXOSC8 IL20RA IL20RB EXOSC3 IL22RA2 EXOSC2 IL22RA1 EXOSC1 PIGR HSPA8 TMC6 SERPINB10 MAPK14 SERPINB12 RNASEL MAPK11 CTF1 TCIRG1 FLNB EIF4G1 LRG1 OLFM4 TXLNA FSCN1 PTPRB IL1RAPL1 ATP6V0B PRCP PTPN9 PTPN5 ATP6V1B2 PTPN2 VPS35L ATP6V0C ATP6V1B1 RBX1 IFI35 DHX58 RSAD2 DHX36 SURF4 PRG2 PRG3 ORM2;ORM1 QSOX1 CD53 OSMR CD63 PGRMC1 CREG1 CD68 IL17C ATP6V1G3 MPO OSTF1 CD93 PRKACB-1 MID1 DOK3 KIF3A ISG20 IL7 TARM1 IRF6 IRF9 MVP PDAP1 ATP6V0E2;ATP6V0E1 S100P ITCH CNTFR ABCA13 NHLRC3 UNC13D RNF125 A1BG CRACR2A PRDX4 FKBP1A S100A11 PA2G4 CD3G SERPINA3 TRIM8 TRIM6 TRIM5 SYK TRIM2 TRIM3 FGR HCK HAVCR2 NFAM1 AGA HRAS CARD9 FCGR3A;FCGR3B ERP44 FYN SLCO4C1 FCGR1A GHDC CSF3R CUL3 EPX LGALS9C;LGALS9;LGALS9B ALPK1 CLEC4A NLRX1 NRAS CLEC4D CLEC4E AGER S100A12 BRI3 KBTBD7 N4BP1 HVCN1 CFD USP18;USP41 CLEC7A MYD88 C3-1 NDN CFB CLEC6A NFKBIB SAA2;SAA1 CCNK PTPN20 NUP107 PTPN23 NKIRAS1 NUP188 KCNAB2 NKIRAS2 IKBIP CCNT1 IL3RA IRAK4 EIF4E2 PELI1 PTPN14 TLR9 PDE12 LRRC14 KPNA1 SIGLEC15 SUPT16H PTPRN2 USP14 NUP210 PELI3 STK11IP PELI2 IFNLR1 NLRC5 IL17RE TIFA GTF2F1 IL17RB HMGB1-1 GTF2F2 DNASE1L1 MAP3K1 NUP93 ATAD3A;ATAD3B IL18RAP DPP7 DNAJC13 CRISP3 NUP205 HEBP2 CMTM6 NEDD4L ABCE1 AAAS NUP160 NUP85 TPR NUP88 AP1G1 SUPT4H1-1 FTH1 AP1S2 XRCC6 NUP155 AP1S1 AP1S3 XRCC5 NUP153 AP1B1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 VAMP8 CCNT2-1 RAB5C TAF4B ELL ELOC-1 TAF7L NUP62 ELOA AP1M2 NELFB TXNDC5 ELOB AP1M1 NELFCD NELFA CCR5 FTL-1 NELFE NDC1 SEC13 NUP133 IGF2R NUP50 POM121;POM121C NUP54 CSF2RB CSF2RA CTDP1 TAF9 CISH POLR2A NUP42 IRS2 POLR2B PRL POLR2C PRLR GHR POLR2D SOCS2 SOCS1 NUP43 POLR2G TAF9B POLR2I RAE1 RANBP2 TAF15 PPP3R1 TAF12 TAF13 TAF10 TAF11 SSRP1 TAF8 TCEA1 TAF7 NUP35 TAF6 PPP3CA TAF5 PPP3CB TAF4 TAF3 TAF2 TAF1 NUP37 HEXB GLB1 GUSB ARSB CHUK UBA7 HSPA5 DDX58 EIF2AK3 ISG15 UBE2L6 IFI44L HERC5 IFIH1 IKBKB TRIM25 ARIH1 IKBKG ATF6 FKBP5 CLTC CLTA LRR1 AP2A1 CCNF AP2B1 KEAP1 CBLB AP2A2 DNM1 DCAF1 HERC4 DNM2 HERC3 DNM3 AP2S1 RNF115 HERC2 SH3GL2 RNF114 HERC1 TRIM21 PPP2CB;PPP2CA FBXO7 FBXO9 PPP2R5B HERC6 PPP2R5A TRAIP-1 PPP2R5D PPP2R5C WSB1 FBXO2 PPP2R1B RNF123 RNF126 HECW2 PPP2R5E ANAPC13 UBE2J2 UBE2J1 RNF217 ATG7 TRIM11-1 HACE1 SIAH2 SIAH1 LNPEP MEX3C UBAC1 FBXL8 FBXL4 FBXL7 DZIP3 RNF220 DET1 ITGB1 LRSAM1 TRIM9 ARIH2 RNF144B GAN PRKN GATA3 RNF130 GPR75-ASB3;ASB3-1 HUWE1 KLHL2 FGF2 KLHL3 UBE2G1 UBE2G2 KLHL9 PLAC8 SPSB2 SPSB1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 UBR2-2 LTN1 RNF19B UBE3A UBE3B UBE2Z FBXO21 FBXO22 NPEPPS RNF19A MYLIP FBXW12 AREL1 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 CD274 UBE2E2 LMO7 IRS1 FBXO10 PIK3R2 FBXO11 PIK3CB KLHL41 KCTD7 PIK3R1 RNF41 IL2RG KLHL42 UBE2V2 HIF1A PTPRZ1 CUL7 CUL5 UBA6 MYC UBA5 CUL2 JAK3 UBR4 KLHL11 MYCN KLHL13 UBR1 PIK3CA FBXO44 PTPN6 FBXO41 TNRC6C MOV10 FBXO40 TNRC6A-1 BTBD1 AGO4 LONRF1 AGO2 UBE2F UBE2H UBE2B AGO3;AGO1 TNRC6B KLHL25 ZBTB16 GLMN TGFB1 CCND1 KLHL21 KLHL22 KRAS BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBOX5 UBE2U ALOX5 MKRN1 UBA3 RNF182 TPP2 UBE2O BLMH UBA1 UBE2K TRIM71 RNF14 KBTBD13 CSF1R UFL1 UBE2Q1 UBE2Q2 TRIM69 UBE2D1 UNKL RELA ANAPC10 DTX3L ANAPC11 PJA2 PJA1 FZR1 CDC23 TRAF7 CDC26 UBE2R2 RNF138-1 CDC27 THOP1 TCF7L2 RNF213-2 ANAPC7 MGRN1 UBE2C ASB13 ASB14 UBE2E1 RNF6 NFKB1 ASB11 IL6 UBE2S RNF7 CDC16 ASB12 ASB17 ANAPC4 RNF4 ANAPC5 RCHY1 ANAPC1 ASB18 ANAPC2 FBXL22 ASB15 ASB16 FBXL20 ZNRF1 ZNRF2 RPS15 HECTD1 RPS14 HECTD2 ASB10 RPS17 TBK1 HECTD3 TRIM41 RPS16 RNF25 FBXL19 RPS19 FBXL18 FBXL15 RPS18 AKT2 TRIM74;TRIM73;TRIM50 AKT3 FBXL16 FBXL13 FBXL14 RPS11 FBXL12 B2M TRIM39 RPS10 ASB8 RPS13 ASB9 RPS12 LNX1 ASB6 TRIM36 ASB7 TRIM37 ATG14 ASB4 ASB5 ASB2 TRIM32 RPN2 SAR1B ASB1 RPN1 PIK3R4 SFN RIPK3 GSDME RPS25 RPS27 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 MAGT1 IKBKE JAK1 TOMM70 RIPK2 ANO6 TYK2 IL17RC PRKCE PLPP5 IL17RA PLPP4 MYO10 MYO5A SIKE1 MYO1C CANX TLR8 TLR7 RPS27L PPL RNF135 RPS15A RPS3 RPS2 STAT1 STAT2 SEC24D-1 PKP1 STING1 IL17F FAU VCP-1 DSC1 IL17A TUSC3 KPNA2 MAP3K7 GSDMD RPS9 RPS7 CASP9 RPS8 RPS5 RPS6 RPSA GOLGA7-1 TMEM258 MASP1 UBE2V1 NOS1 IFNAR1 TKFC IRAK1 IRAK2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 MAVS OSTC SQSTM1 STT3A UBE2N FLT3 TAB3 TAB2 STT3B TAB1 HSP90AB1 PRKCSH RPS4X FRK PDPK1 RPS3A DDOST C3AR1 IRF3 IL18 DAD1 IL1A TRAF3 IL1B MBL2-1 TRAF6 IRF7 PIK3C3 BECN1 SEC23A NOD1 NOD2 EIF4A2 EIF4A1 VHL SEC24B IFNB1-4 SEC24A PTPN11 SEC24C EIF4E AICDA CALM3;CALM1 CHRNB4 FBXO4 FBXO6 FBXW4 CCT2 FBXW10;CDRT1 FBXW5 FBXW7 SPHK1 FBXW9 FBXW2 LRRC7 TCP1 CCT8 FBXL3 FBXL5 B4GALT1 SEL1L RAB6A JUN MAPK7 CDKN1B RAC1 RHOA ELMO1 ELMO2 CRK DOCK1 EPAS1 CBL SOCS3 PTPN1 CDK4 VNN1 EIF4A3 ITGB5 ITGAV THOC5 TRPM2 TRPC1 JUND TICAM2 LY96 FASLG TRAF2 FOSB TICAM1 CASP8 RIPK1 CD14 FADD TLR4 SHC1-1 CDC34 PRKCQ CARD11 BCL10 RFC1 RASGRP2 RASGRP1 MALT1 RASGRP4 LYN UBE2D3;UBE2D2 NFKBIA POLD3 POLD2 MAP2K2;MAP2K1 RAP1A COPS5 RAPGEF1 MAPK1 MAPK3 CRKL SOS1 NPC2 GRB10 IFNGR1 IFNGR2 P4HB APOB CDC20 PRKAB2 EIF3C;EIF3CL EIF1AY;EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B LTA4H LGMN PRKAG2 GSTO1 RAB3A RAPGEF3 RAPGEF4 GSTP1 DERL2 RNF5 OS9 RNF185 NANOG;NANOGP8 ACLY FLT3LG CD19 EGR1 SLC27A2 CD28 GAB2 IL33 CD86 CD80 IP6K2 IL1RL1 TRAT1 PIK3AP1 SDCBP CASP5;CASP4 HPSE OSBPL1A SNAP25 KPNA4-1 PTEN FN1 ALAD PGM2 PGM1 FNTA MSH6 C1S E2F2 PDCD1 PRKAA2 DHX9 BST2 GRB2 IL22 IL6R PPIE CD8B;CD8B2 TALDO1 TRIB3 PTGS2-2 WDR61 ICOS NEU1 IL10RA BST1 RAB5B MCL1 TIRAP GSTA3;GSTA5;GSTA1;GSTA2 CEBPD CD33-1 IL1R1 GAA APRT AGL-1 CD79B CD79A TLR6 TLR5 ORMDL3 XDH FNTB;CHURC1-FNTB CGAS INPPL1 BLNK HGSNAT C4BPA C4BPB LOC110384692;C4A;C4B_2;C4B GBP6 ERLIN1 ERLIN2 TLR10 CALR-1 PIM1 KPNA7 KPNA5 KPNA3 S100A1 CTNNBL1 DEGS1 PPM1B CA1 CTR9 RTF1 PCBP2 SEC31A PAF1 DERL3 DERL1 ZBP1 VCL LRRFIP1 DYNLT1 GALNS DCTN1 GLA CDA GBP7;GBP4 ERLEC1 ARMC8 MTAP BIN2 GNS MRC1 HMOX1 BRD4 DDX3X-1 HMOX2 CLEC5A VTN TCN1 EIF4G3 EIF4G2 PYGB EIF4E3 GPI PYGL UNC93B1 CLEC4M;CD209-2 PTPN12 SH3KBP1 PDIA3 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol NR1H4 CYP8B1 RXRA AMACR CYP7A1 SLC27A2 SLC27A5 BAAT ABCB11 ABCD3 HSD17B4 ACOX2 ACOT8 CYP27A1 AKR1D1 NCOA1 NCOA2 HSD3B7 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69613 p53-Independent G1 S DNA Damage Checkpoint TPTEP2-CSNK1E;CSNK1E RBX1 GSK3B CSNK1A1 PSMD12 CHEK2 PSMD11 CHEK1 PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PLK3 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 FBXW11 NEK11 UBA52 CUL1 RPS27A UBB;UBC MAPK14 MAPK11 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID IKBKB IKBKG CHUK KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism BDH1 OXCT1-1 ACAT1 SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 97%2644603 Signaling by NOTCH1 in Cancer RBX1 CDK8 DLL4 PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 HDAC8 JAG1 ADAM10 HDAC9 NOTCH1 HDAC6 ADAM17 HDAC7 RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN NEURL1B MAML3 MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 UBA52 CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 97%1650814 Collagen biosynthesis and modifying enzymes ADAMTS2 ADAMTS3 P4HB COL4A5 COL16A1 COL12A1 COL1A1 COL1A2 ADAMTS14 COL23A1 COL17A1 COL13A1 COLGALT2 PLOD3 PLOD2 PLOD1 COL10A1 BMP1 COLGALT1 COL9A1 COL27A1 COL9A3 P3H2 COL9A2 COL18A1 P3H1 COL14A1 PCOLCE P3H3 COL2A1 COL4A2 COL4A1 COL4A4 COL6A2 COL4A3 COL6A1 COL8A2 COL4A6 COL21A1 COL8A1 COL6A3 COL6A6 COL6A5 PPIB COL25A1 PCOLCE2 COL11A1 COL11A2 SERPINH1 COL28A1 CRTAP COL24A1 COL22A1 COL3A1 P4HA1 COL5A1 P4HA2 COL5A3 P4HA3 COL7A1 COL5A2 COL20A1 COL15A1 COL19A1 COL26A1 TLL2 TLL1 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters SLC2A13 SLC5A11 SLC5A3 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins LTA4H ALOX5 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696395 Formation of Incision Complex in GG-NER RBX1 CDK7 MNAT1 PIAS3 UBE2I PARP2 USP45 DDB2 UBE2N RAD23A ERCC3 CHD1L UBA52 PARP1 ERCC5;BIVM-ERCC5 RAD23B PIAS1 ERCC2 GTF2H1 DDB1 GTF2H3 GTF2H4 RPA1 XPA SUMO1 RPA2 SUMO3 SUMO2 XPC RPA3 RPS27A CUL4A UBB;UBC RNF111 ERCC4 ERCC1 CETN2 UBE2V2 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH CUL4B TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway SPATA2 TNFAIP3 SHARPIN USP21 USP4 RACK1 TNFRSF1A TRADD CYLD RBCK1 OTUD1 TRAF2 BIRC2 CHUK BIRC3 OPTN-1 RIPK1 TNF IKBKB IKBKG TAB3 TAB2 TRAF1 TAB1 MAP3K7 RNF31 XIAP USP2 OTUD7B GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity CAMK2G MDM2-2 GRIA2 MYO6 CACNG8 CACNG2 CACNG3 CACNG4 AP2A1 PRKCG DLG4 PRKCA GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 CAMK2B CAMK2D CAMK2A PRKCB AKAP5 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 97%1299361 TWIK-related alkaline pH activated K+ channel (TALK) KCNK16 KCNK17 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-HSA-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV DLD BCKDHA DBT BCKDHB GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 97%888590 GABA synthesis, release, reuptake and degradation SLC32A1 RAB3A SLC6A13 SYT1 ABAT SLC6A1 VAMP2 STX1A CPLX1 ALDH5A1 SNAP25 RIMS1 DNAJC5 SLC6A12 SLC6A11 HSPA8 GAD1 GAD2 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes PITPNB INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 97%8981607 Intracellular oxygen transport MB NGB CYGB DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9699150 Defective DNA double strand break response due to BARD1 loss of function BARD1 BRCA1 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 97%69166 Removal of the Flap Intermediate PRIM2 RPA1 PRIM1 RPA2 POLA1 POLA2 POLD3 POLD4 DNA2 RPA3 POLD2 FEN1 POLD1 PCNA DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.3 CLEC7A (Dectin-1) signaling UBE2V1 RELB UBE2N TAB3 TAB2 PSMD12 TAB1 PSMD11 ITPR1 PSMD14 ITPR2 PSMD13 ITPR3 PPP3R1 PSMA7 PDPK1 NFKB2 PSMD8 PYCARD PSMB6 PSMB7 PSMD6 PSMB4 NFATC2 PSMD7 IL1B NFATC1 TRAF6 PSMB5 SYK PSMB2 PSMB3 PPP3CA PSMD2 PPP3CB PSMD3 PSMB1 PSMD1 CARD9 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CLEC7A PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 PLCG2 CHUK CASP8 FBXW11 CALM3;CALM1 CDC34 IKBKB CARD11 BCL10 IKBKG UBA3 MALT1 UBE2D3;UBE2D2 UBA52 NFKBIA NFATC3 PRKCD CUL1 UBE2D1 RELA RPS27A MAP3K14 AHCYL1 UBB;UBC NFKB1 MAP3K7 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing PRKG2 LYPLA1-1 ARL2 FNTB;CHURC1-FNTB USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 ABHD17C ZDHHC9 ABHD17B ABHD17A RCE1 BCL2L1 KRAS CALM3;CALM1 PRKCQ ICMT HRAS FNTA PDE6D GOLGA7-1 NRAS ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112126 ALKBH3 mediated reversal of alkylation damage ALKBH3 ASCC1 ASCC2 ASCC3 RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle BCR ITGB1 PIK3R3 PAK1 DOCK4 PGRMC2 DOCK3 SAMM50 ABR NCKAP1L PAK4 GIT2 MCAM MTX1 CAV1 MPP7 ESYT1 ARHGAP1 DSG2 EMD ARHGAP39 DOCK2 CDC42EP4 SYDE1 CDC42 ARHGAP42 IQGAP1 CDC42EP1 ARHGDIA VAMP3 PIK3R2 NHS SLITRK5 CYBB CYBA PIK3R1 WASF2 LMAN1 ARHGAP21 LBR PIK3CA ARHGAP17 BAIAP2L1 OPHN1 TMPO ARHGAP35 MCF2 LEMD3 DEF6 VANGL1 ABI2 DEPDC1B GARRE1 TAOK3 RAB7A ARHGAP26 ABI1 DOCK1 EPHA2 ARHGAP32 VAPB PLD2 PAK2 DIAPH3 TIAM1 NCF1 NCF2 DOCK10 NCF4 STBD1 CYFIP1 GIT1 NCKAP1 ANKLE2 VAV3 SWAP70 VRK2 TRIO TFRC ARMCX3 LAMTOR1 ERBIN VAV1 VAV2 PREX1 RACGAP1 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 ARNTL RBFOX3 TNRC6C ARNT2 NPAS4 MOV10 MDM2-2 TNRC6A-1 RET AGO4 AGO2 AGO3;AGO1 TNRC6B CDK5 IQSEC3 KCNIP3 INS;INS-IGF2 PLK2 FOS CREBBP XPO1 NR3C1 BDNF GEM CDK5R1 REST SRF NAMPT SYT10 MAPK1 MAPK3 ARNT TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane GJB2 GJA1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.8 Cytosolic sulfonation of small molecules PODXL2 TPST2 BPNT2-1 SULT6B1 SULT4A1 SULT1C2 TPST1 SULT2A1-4 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT1B1-1 ABHD14B BPNT1 SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9705683 SARS-CoV-2-host interactions RPS14 GJA1 RPS17 NUP133 TLR2 TBK1 RPS16 SNRPD2 RPS19 SNRPD1 RPS18 NUP50 AKT2 POM121;POM121C AKT3 SNRPD3 NUP54 RPS11 B2M RPS10 VPS39 RPS13 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ATG14 NUP42 SAR1B CREBBP PIK3R4 NUP43 VPS11 SNRPE-2 SFN RAE1 RANBP2 VPS16 RPS25 RPS27 RPS29 RPS20 NUP35 RPS21 RPS24 RPS23 YWHAE IKBKE JAK1 TOMM70 NUP37 RIPK2 SFTPD TYK2 IL17RC YWHAG IL17RA CHUK HSP90AA1 SIKE1 SMN2;SMN1 DDX58 TLR8 ISG15 TLR7 RPS27L IFIH1 RNF135 IKBKB RPS15A TRIM25 YWHAB IKBKG RPS3 AKT1 RPS2 NUP214 STAT1 STAT2 YWHAZ SEC24D-1 MPP5 TJP1 NLRP12 STING1 IL17F FAU RPS27A CRB3 IL17A GEMIN2 KPNA2 MAP3K7 RPS9 RPS7 RPS8 RPS5 VPS33A RPS6 VPS33B RPSA TUFM GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 GEMIN7 GEMIN8 IFNAR1 SNRPB TKFC IRAK1 IRAK2 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E UVRAG CAV1 MAVS UBE2N TAB3 TAB2 TAB1 HSP90AB1 RPS4X YWHAQ YWHAH PDPK1 RPS3A LARP1-1 IRF3 TRAF3 MBL2-1 TRAF6 IRF7 PIK3C3 BECN1 SEC23A DDX20 NOD1 NOD2 SNRPG-2 CNBP-1 SEC24B IFNB1-4 SEC24A PTPN11 PTPN6 VPS41 NUP107 NUP188 VPS45 SEC24C NUP210 NUP93 NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 NUP62 PATJ TLR1 NDC1 RPS15 SEC13 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation KARS1 PPA2 RARS2 AARS2 PARS2 MARS2 DARS2 HARS2 YARS2 FARS2 WARS2 GARS1 LARS2 SARS2 NARS2 TARS2 IARS2 VARS2 CARS2 QARS1 EARS2 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 97%5545483 Defective Mismatch Repair Associated With MLH1 PMS2 MLH1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME%R-HSA-141333.6 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOA MAOB DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 97%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 POMT2 DAG1 POMT1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 97%9857492 Protein lipoylation NFU1 LIPT1 LIAS NDUFAB1 DBT DLAT DLST FDX1 GCSH-3 LIPT2 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 97%392023 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2A ADRA2B DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9920951 Dengue virus modulates apoptosis RICTOR PRR5 MTOR DAXX NFKBIB MLST8 RPTOR RIPK1 MAPKAP1 PIK3C3 RETREG1 TAOK1 BECN1 ATG14 PIK3R4 NFKBIA DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.7 Diseases of hemostasis GP1BA FGG ANO6 TPST2 F2 TPST1 F5 F8 ADAMTS13 VWF F9 F10 F11 GP5 GP9 PROC GGCX PROS1 FGB FGA GP1BB TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 97%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 CDK1 HDAC1 RBBP4 MYBL2 CCNA2-1 E2F4-1 E2F5 TFDP1 RBL2 TFDP2 RBL1 LIN54 LIN37 LIN9 LIN52 E2F1 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors HTR1A HTR1B HTR2B HTR2A HTR5A HTR4 HTR6 HTR7 HTR1E HTR1F HTR1D SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer NOTCH1 ADAM17 MIB2 DLL1 JAG2 DLL4 RPS27A NEURL1 UBB;UBC NEURL1B MIB1 JAG1 UBA52 ADAM10 DISEASES OF METABOLISM%REACTOME DATABASE ID RELEASE 97%5668914 Diseases of metabolism C1GALT1C1 DPM1 ADAMTS2 PPP1R3C DPM2 ADAMTS3 DCXR SLC34A2 ADAMTSL5 DPM3 MMADHC ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ADAMTS7 SBSPON TPMT MUC3A B4GALT7 MUC5AC ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 CTSA THSD4 MOGS ADAMTS10 PRELP ADAMTS15 ADAMTS14 SDC4 MUC1 KERA MUC2 ADAMTS19 B3GAT3 SDC2 ADAMTS17 SDC3 MUC7 MUC4 MUC6 SLC26A2 GALNT3 POMC NOTCH1 MUC17 C1GALT1 MUC5B MUC20 MUC21 ST3GAL3 LFNG SDC1 GFPT1 SFTPD MUC13 CHST6 MCCC2 BTD PC GGT1 PCCA HLCS MCCC1 MAT1A PCCB ACACA CYP21A2 GPC1 GPC3 BCKDK GPC2 GPC5 UBA52 GPC4 CYP11A1 MGAT2 GPC6 MTRR CHST3 ADAMTS13 GCLC GCLM AGRN RPS27A UBB;UBC BCKDHA BCKDHB CYP2U1 LMBRD1 SLC35D1 PNP-1 RPIA CYP24A1 CD320 GBE1 CYP7B1 G6PC1 G6PC3 OGN HSPG2 TBXAS1 BCAN FDXR CYP1B1 B4GAT1 DAG1 MMUT ADAMTS16 LARGE1 CUBN POMGNT1 ADAMTS18 MAN1B1 PGM1 GNE FDX1 NHLRC1 ADAMTS4 ADAMTS5 HPRT1 ADAMTS1 ALG8 ADAMTS8 ALG9 ALG6 ADAMTS9 ALG2 CHST14 ALG3 ALG1 MC2R DCN IDH1 NAGS ADA DHDDS GALM-2 OMD TALDO1 ACAN IVD OPLAH CYP2R1 DBT NEU1 EXT1 FMO3 EXT2 SFTPB FMOD SFTPC LUM CSF2RB CHSY1-1 CSF2RA NAGLU GYG2 GYG1 KHK GAA APRT CYP4F22 GALE SI AHCY LCT B4GALT1 CYP17A1 NOTCH2 NOTCH3 IDUA ALG14 NOTCH4 HEXB ALG12 NCAN ALG11 HEXA SLC37A4 BGN AMN UGT1A1;UGT1A6 VCAN GLB1 HYAL1 IDS CSPG5 GUSB ARSB HGSNAT RFT1 ASS1 MMACHC ABCA3 PMM2 DLD MTR-1 CYP27A1 ACY1;ABHD14A-ACY1 GALK1 MAOA CYP26B1 CYP27B1 ASL EPM2A CBLIF GALT DPAGT1 MPI CYP19A1 GYS2 GYS1 ACAT1 AUH DOLK SRD5A3 B3GALT6 GALNS CYP11B1;CYP11B2 ECHS1 CPS1 ARG1 OTC ALDOB SLC25A15 THBS1 GNS TCN2 PPM1K PAH MPDU1 NMRAL1 MMAA ABCD4 MMAB NUS1 SGSH PAPSS2 POMT2 SEMA5A SPON2 SEMA5B SPON1 HIBCH THSD7B GSS POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS NGF SOS1 RALA-1 MAPKAPK2 SHC3 SHC1-1 MAPK14 HRAS MAPK11 SHC2 MAPK12 MAPKAPK3 RALGDS NTRK1 RALB MAPK13 NRAS CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 97%159424 Conjugation of carboxylic acids ACSM1 GLYATL3 ACSM5 ACSM4 ACSM2A;ACSM2B GLYAT POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 97%163125 Post-translational modification: synthesis of GPI-anchored proteins DPM1 DPM2 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L PIGS DPM3 CPM LY6K BST1 PIGU PGAP1 PIGT PSCA PIGO PIGN GPAA1 PIGP PIGZ MSLN PIGW ALPG;ALPP;ALPI-1 PIGV PRSS21 PRND TECTB IZUMO1R RTN4RL2 PIGC PIGB NRN1L RTN4RL1 CD109 PIGA LY6D PIGK PIGM SPACA4 PIGL PIGG LY6H PIGF GPLD1 PIGH NRN1 NTM TEX101 LYPD1 LYPD2 LYPD3 LYPD4 THY1 LYPD5 ART3 LYPD8 ART4 OTOA LY6G6C OPCML NTNG1 FCGR3A;FCGR3B NTNG2 PLAUR NEGR1 CNTN5 LY6E PIGX-1 LSAMP GP2 PLET1 PRSS41 GPIHBP1 XPNPEP2 LYPD6B ALPL CNTN3 MELTF CNTN4 TECTA;TBCEL-TECTA MDGA2 RECK MDGA1 SPRN CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 FOLR2 VNN1 VNN2 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS MAOA SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters SLC32A1 SLC6A3 SLC6A4 SLC6A13 SLC25A22 SLC6A1 SLC6A19 SLC6A15 SLC22A2 SLC6A14 SLC22A1 SLC6A9 SLC17A6 SLC17A7 SLC6A11 SLC6A7 SLC17A8 SLC6A20 SLC25A18 SLC6A5 SLC6A2 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 97%418038 Nucleotide-like (purinergic) receptors P2RY6 LPAR4 P2RY2 P2RY1 GPR17 P2RY10 P2RY11 LPAR6 P2RY12 P2RY13 P2RY14 ADORA2B ADORA2A ADORA3 ADORA1 P2RY4 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 97%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 CASP10 FADD RNF135 IFIH1 IKBKB TRIM25 MAVS IKBKG CHUK CASP8 DDX58 RIPK1 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8940973 RUNX2 regulates osteoblast differentiation HDAC6 HES1 ABL1 AR SRC ZNF521 YAP1-1 WWTR1 YES1 CBFB SATB2 COL1A1 MAPK1 RB1 UCMA MAPK3 MAF HEY1 HEY2 GLI3 SP7 HDAC3 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 97%1799339 SRP-dependent cotranslational protein targeting to membrane RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 SEC11A SEC11C SSR1 RPL27A RPL10;RPL10L-1 RPS25 RPS27 RPS29 SRP14 RPS20 RPS21 RPS24 SPCS3 RPS23 SPCS2 SPCS1 RPL36AL-1 RPL7A RPLP0 SRPRA SRP19 RPLP2 TRAM1 RPL36-1 RPL35A SRP54 SSR4 SSR2 RPS27L SSR3 SRP9 RPS15A SRP72 SRP68 RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 SEC61A2 SEC61A1 RPL21 SEC61G RPL23 SEC61B RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 RPL23A RPL11 RPL14 SRPRB-1 RPL13 RPL18 RPL17 RPL19 RPS15 HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection TRIM28 NUP133 DYNC1LI1 VPS37C DYNC1LI2 VPS37D ITGB1 VPS37A VPS37B NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 DYNC1I1 CEBPD VPS4A H2BC18 NUP42 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MVB12B MVB12A NUP43 H2BC21 RAE1 RANBP2 DAXX H2AC20 EED EZH2 CHMP1A UBAP1 NUP35 CBX1 EGFR NUP37 VPS36 SNF8 VPS25 HDAC3 PML NUP107 NUP188 RBBP4 NCOR2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP210 NCOR1 RBBP7 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 GPS2 TSG101 H2BC15;H2BC3;H2BC11;H2BC12 AAAS SUZ12 H2BC5 NUP160 NUP85 H2BC1 NUP214 DYNC1I2 TPR NUP88 NUP155 NUP153 CHMP2B ELK1 CHMP2A H2AC16;H2AC11 H2AC4 NFKB1 NUP62 TBL1XR1 DYNC1H1 HNRNPK NDC1 H2AC14 SEC13 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 97%2129379 Molecules associated with elastic fibres ITGB1 BMP10 ITGB5 ITGB8 EFEMP2 EFEMP1 ITGAV ITGB6 TGFB1 VTN FBLN1 FBLN2 FBLN5 ITGB3 BMP7 BMP4 BMP2 MFAP5 ITGA8 MFAP4 MFAP3 LTBP4 MFAP2 LTBP2 LTBP3 LTBP1 TGFB2 TGFB3 GDF5 ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation NAT1 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation CDK1 ATM PPP2R1A MTOR MDM2-2 AKT2 AKT3 CCNA2-1 CCNA1 AKT1 MDM4 UBA52 SGK1-1 CHEK2 RICTOR PRR5 DAXX PDPK1 CDK2 PPP2CB;PPP2CA MLST8 PHF20 RPS27A PPP2R5C CCNG1 CDKN2A PPP2R1B MAPKAP1 UBB;UBC TP53 PRDM1 RNF34 USP7 RFFL USP2 PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism PNP-1 GDA NT5C NT5E DNPH1 NT5C1A NT5C1B;NT5C1B-RDH14 NT5C2 ITPA XDH NUDT16 ADPRM NUDT15 NUDT5 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades FGF20 SOS1 SPTBN2 FGF23 MARK3 IL2RB PPP1CC RGL1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 RAG2 PSMD2 RAG1 DLG1 EGF PSMD3 IL5 ERBB2 PSMB1 PSMD1 EGFR JAK1 PDGFRA ADRM1 FGF6 PSMC2-1 PSMA2-1 PPP1CB PSMA5 RAP1B PRKACA-1 HGF SEM1 PSMA6 PRKG2 PSMC5 PPP2R1A TYK2 PSMA3 MET DNAJB1 PSMC6 PSMA4 PTPN3 AREG PSMC3 PSMA1 PSMC4 PSMC1 IL5RA FGF7 FGF22 FGF3 FGF10 RAF1 ICMT YWHAB HSPB1 XPO1 KIT UBA52 ZDHHC9 VWF RPS27A UBB;UBC GOLGA7-1 CDK1 FLT3LG PDGFB RBX1 BCL2L1 KLB GRIN2B PDGFRB FGF19 FGFR4 PRKACB-1 JAK2 FLT3 LYPLA1-1 FN1 CDC42EP5 CDC42EP3 CDC42 DUSP8 CDC42EP2 DUSP9 SPRED3 SPRED2 RASA4;RASA4B SPRED1 SYNGAP1 HRAS FNTA RASA3 RASA1 FYN RASA2 CUL3 RASAL1 NRTN RASAL2 RASAL3 NCAM1 NRAS DAB2IP PSPN NF1 GFRA2 KBTBD7 GFRA4 ARTN PTPN11 DUSP5 DUSP2 DUSP1 PAQR3 IL3RA PTPN7 FOXO3 CALM3;CALM1 ACTN2 CNKSR2 CNKSR1 PEBP1 GRIN2D IL6R EPGN PAK2 ARRB1 DLG2 DLG3 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RASGRF1 ABHD17C ABHD17B ABHD17A RCE1 SHC3 PTPRA NEFL SPTB LRRC7 IL2RA MAPK12 APBB1IP ARL2 TGFA SPTBN4 CSF2RB SPTBN5 CSF2RA MAP3K11 DUSP4 FOXO1-1 RASGRF2 GRIN1 DUSP6 DUSP7 GFRA3 IRS2 SHC2 RALGDS CCND3 TLN1 SPTA1 IL2 IL3 SRC IQGAP1 ARRB2 CSK NCOA3 JUN FNTB;CHURC1-FNTB RAC1 NRG1 NRG2 ARAF EREG BTC KALRN RASGRP3 NRG3 NRG4 SPTBN1 WDR83 RGL3 PDE6D RGL2 HBEGF PEA15 PTK2 IL17RD RAPGEF2 PPP5C SEPTIN7 CDC14A CDC14B RASGEF1A ETV4 CSF2 IGF2BP1 ITGA2B MAPK6 MAPK4 PPP2CB;PPP2CA SPTAN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B LAMTOR2 PPP2R5E LAMTOR3 PHB KSR1 KSR2 MAPKAPK5 RET PAK1 FGF2 PAK3 VCL GFRA1 GDNF IRS1 PIK3R2 PIK3CB PIK3R1 IL2RG CAMK2B MYC BRAP CAMK2D CAMK2A JAK3 FRS2 PIK3CA CAMK2G MRAS TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 RANBP9 TNRC6B ANGPT1 KRAS TEK SHC1-1 PRKCQ ITGB3 RASGRP1 RASGRP4 DUSP16 DUSP10 FGB FGA DLG4 FGG MAP2K2;MAP2K1 IL6 RAP1A MAPK1 BRAF MAPK3 SHOC2 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 PPP2R1A PTPN11 LCK PPP2CB;PPP2CA AKT2 AKT3 PPP2R5B PPP2R5A YES1 PPP2R5D CD86 PPP2R5C CD80 PPP2R1B PPP2R5E FYN LYN CTLA4 AKT1 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.3 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 97%174430 Telomere C-strand synthesis initiation CTC1 PRIM2 STN1 PRIM1 TEN1 POLA1 ACD POLA2 TINF2 TERF2 POT1 TERF2IP TERF1-1 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%5173105 O-linked glycosylation C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ADAMTS7 SBSPON B4GALT6 MUC3A MUC5AC ADAMTS20 B4GALT5 B3GLCT ADAMTS12 CFP THBS2 THSD1 ST6GAL1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 MUC6 GALNT3 ST3GAL4 MUC17 C1GALT1 MUC5B ST3GAL1 MUC20 ST3GAL2 MUC21 ST3GAL3 MUC13 GALNT11 GALNT14 ADAMTS13 GALNT13 GALNT16 GALNT15 GALNT18 B3GALNT2-2 GALNT10 POFUT2 EMID1 GALNT9;GALNT17 FUT10 FUT11 GALNTL5 GALNTL6 B3GNTL1 GALNT9 GALNT8 POMGNT2 B3GNT9 B3GNT8 MMRN1 B3GNT6 MMRN2 CHST4 GCNT1 GCNT3 GCNT4 GALNT7 GALNT6 GALNT5 GALNT4 MGAT5B-1 A4GNT POMK ST6GALNAC2 SLC35A1 SLC35A4 FKRP B4GAT1 CRPPA CHST10 DAG1 RXYLT1 LARGE1 ADAMTS16 LARGE2 POMGNT1 B3GNT7 FKTN ADAMTS18 B3GNT5 B3GNT4 B3GNT3 ST6GALNAC3 B3GNT2 ST6GALNAC4 ADAMTS4 ADAMTS5 THBS1 GALNT2 ADAMTS1 GALNT1 ADAMTS8 ADAMTS9 POMT2 SEMA5A SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1;POU5F1B SOX2 NANOG;NANOGP8 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS SFTPB INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels KCNJ2 KCNJ12;KCNJ18 ABCC8 KCNJ3 KCNJ4 GNG10 GABBR2 GNG2 KCNJ5 GNG5 KCNJ1 GABBR1 GNG4 KCNJ6 KCNJ8 KCNJ10 GNG8 ABCC9 KCNJ11 KCNJ9 KCNJ15 KCNJ16 KCNJ14 GNG13 GNB2 GNB1 GNB4 GNB3 GNGT1 GNB5 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-HSA-5610780.2 Degradation of GLI1 by the proteasome PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 NUMB PRKACB-1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 ITCH CUL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GLI1 PSMC2-1 PSMA2-1 PSMA5 PRKACA-1 SEM1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition RPS14 RPS17 RPS16 RPS19 RPS18 EIF5 RPS11 RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F RPS4X EIF3D EIF3A EIF3B RPS3A RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 EIF4A2 EIF4A1 EIF4E EIF2S2 EIF4B EIF2S3;EIF2S3B EIF2S1 RPS27L RPS15A RPS3 RPS2 FAU RPS27A RPS9 RPS7 RPS8 RPS5 RPS6 EIF4G1 RPSA RPS15 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 97%429947 Deadenylation of mRNA EIF4A3 EIF4E PAN2 EIF4B PAN3 PAIP1 CNOT10 CNOT4 TNKS1BP1 CNOT6 CNOT7 CNOT6L CNOT11 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 PARN PABPC1;PABPC3 EIF4G1 EIF4A2 EIF4A1 TUT7 TUT4 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 97%4549380 Defective ALG1 causes CDG-1k ALG1 HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism ABCC5 HMMR HYAL1 HYAL3 HYAL4 GUSB HYAL2 LYVE1 HAS1 HAS3 HAS2 CHP1 SLC17A5 STAB2 CEMIP HEXB SPAM1 HEXA SLC9A1 CD44 IMMUNOGLOBULIN MATURATION%REACTOME%R-HSA-9938026.1 Immunoglobulin maturation HOXC4 SLAMF6 SPTBN2 SH2D1A EAF1 EAF2 IL21 TNFRSF13C CTSO ACTR1B CTSH CTSF CTSE CTSC RELB HLA-DMA HLA-DMB APEX2 CD40LG CAPZA3 CTSA ACTR10 CD84 LOC102723996;ICOSLG CD4 HLA-DOA HLA-DOB SUPT6H MAF ZBTB17 VCAM1 IRF4 ITGB2 AFF4 TNFSF13B POLI POLH IRF8 DCTN6 DCTN5 STAT6 DCTN4 MLLT1 MLLT3 IWS1 NFKB2 RILP MCM3AP BATF IL4 ACTR1A MAFK CDC73 LEO1 MYB UBA52 DYNC1I2 DIS3 DCTN2 DCTN3 KIF5B KIF5A EXOSC7 KIFAP3 EXOSC6 KIF4B;KIF4A EXOSC5 EXOSC4 KIF20A EXOSC9 RPS27A EXOSC8 CR2 EXOSC3 EXOSC2 UBB;UBC EXOSC1 REV1 DYNC1H1 KLC1 MAD2L2 REV3L KLC4 KLC3 KLC2 RACGAP1 KIF3B KIF3C DYNC1LI1 DYNC1LI2 KIF18A STAT3 KIF11 KIF15 CAPZB KIF3A KIF23 KIF22 KIF2A OSBPL1A CR1L;CR1 KIF2C KIF2B CENPE MSH6 KIF26A CAPZA1 CTSS CAPZA2 E2F2 CTSK C3-1 CCNK CCNT1 CTSD CTSB SUPT16H CTSV;CTSL AICDA GTF2F1 GTF2F2 RAB7A ITGAL SUPT4H1-1 ITGA4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 E2F5 TAF4B ELL ELOC-1 WDR61 TAF7L ICOS ELOA NELFB MEF2B;BORCS8-MEF2B SMARCB1 ELOB NELFCD NELFA NELFE DPF1 DPF2 DPF3 SMARCC1 SMARCC2 CTDP1 PAXIP1 TAF9 POLR2A POLR2B MYH9 POLR2C CREBBP POLR2D SS18L1 POLR2G TAF9B POLR2I SMARCA2 SMARCA4 TAF15 TAF12 CD79B TAF13 CD79A TAF10 TAF11 SSRP1 TAF8 TCEA1 TAF7 ASH2L TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 SS18 NCOA6 ACTL6A PAX5 PCNA PMS2 MLH1 CTNNBL1 KMT2D KMT2C MSH2 ITGB1 CTR9 RTF1 ACTB-1 PAF1 DYNC1I1 BCL6 DPY30 PAGR1 BCL7A BCL7C BCL7B HLA-DPB1-1 WDR5 HLA-DQB2;HLA-DQB1 EXOSC10 EXO1 KDM6A HLA-DPA1 TBP C1D HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 MPHOSPH6 DCTN1 ARID1A HLA-DRA ARID1B RFC5 RFC3 RFC4 RFC2 SMARCD1 CEBPA SMARCD2 JUND SMARCD3 E2F7 E2F8 RBBP5 FOSB POLR2E POLR2F POLR2H POLR2L SMARCE1 RFC1 RELA POLD3 POLD2 NFKB1 ICAM2 IFI30 BACH2 ICAM1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA ACOT8 ACOX3 CRAT AMACR ACOXL CROT HSD17B4 ACOX2 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447038 NrCAM interactions DLG3 DLG4 DLG1 NRP2 CNTN2 ANK1 NRCAM RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade FGF20 SOS1 SPTBN2 FGF23 MARK3 IL2RB PPP1CC RGL1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 DLG1 EGF PSMD3 IL5 ERBB2 PSMB1 PSMD1 EGFR JAK1 PDGFRA ADRM1 FGF6 PSMC2-1 PSMA2-1 PPP1CB PSMA5 RAP1B HGF SEM1 PSMA6 PRKG2 PSMC5 PPP2R1A PSMA3 MET PSMC6 PSMA4 PTPN3 AREG PSMC3 PSMA1 PSMC4 PSMC1 IL5RA FGF7 FGF22 FGF3 FGF10 RAF1 ICMT YWHAB KIT UBA52 ZDHHC9 VWF RPS27A UBB;UBC GOLGA7-1 FLT3LG PDGFB RBX1 BCL2L1 KLB GRIN2B PDGFRB FGF19 FGFR4 JAK2 FLT3 LYPLA1-1 FN1 DUSP8 DUSP9 SPRED3 SPRED2 RASA4;RASA4B SPRED1 SYNGAP1 HRAS FNTA RASA3 RASA1 FYN RASA2 CUL3 RASAL1 NRTN RASAL2 RASAL3 NCAM1 NRAS DAB2IP PSPN NF1 GFRA2 KBTBD7 GFRA4 ARTN DUSP5 DUSP2 DUSP1 PAQR3 IL3RA PTPN7 CALM3;CALM1 ACTN2 CNKSR2 CNKSR1 PEBP1 GRIN2D EPGN ARRB1 DLG2 DLG3 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RASGRF1 ABHD17C ABHD17B ABHD17A RCE1 SHC3 PTPRA NEFL SPTB LRRC7 IL2RA MAPK12 APBB1IP ARL2 TGFA SPTBN4 CSF2RB SPTBN5 CSF2RA MAP3K11 DUSP4 RASGRF2 GRIN1 DUSP6 DUSP7 GFRA3 IRS2 SHC2 RALGDS TLN1 SPTA1 IL2 IL3 SRC IQGAP1 ARRB2 CSK FNTB;CHURC1-FNTB NRG1 NRG2 ARAF EREG BTC RASGRP3 NRG3 NRG4 SPTBN1 WDR83 RGL3 PDE6D RGL2 HBEGF PEA15 PTK2 IL17RD RAPGEF2 PPP5C RASGEF1A CSF2 ITGA2B PPP2CB;PPP2CA SPTAN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B LAMTOR2 PPP2R5E LAMTOR3 PHB KSR1 KSR2 RET FGF2 VCL GFRA1 GDNF IRS1 PIK3R2 PIK3CB PIK3R1 IL2RG CAMK2B BRAP CAMK2D CAMK2A JAK3 FRS2 PIK3CA CAMK2G MRAS RANBP9 ANGPT1 KRAS TEK SHC1-1 PRKCQ ITGB3 RASGRP1 RASGRP4 DUSP16 DUSP10 FGB FGA DLG4 FGG MAP2K2;MAP2K1 RAP1A MAPK1 BRAF MAPK3 SHOC2 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 METAL ION ASSIMILATION FROM THE HOST%REACTOME%R-HSA-9638482.1 Metal ion assimilation from the host HBA2;HBA1 HBD;HBB NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance MAOA SLC6A3 SLC6A4 ALDH2 COMT SLC22A2 SLC22A1 BCHE ACHE LRTOMT GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization CDK1 GOLGA2 CCNB2 CCNB1 RAB2A GORASP2 BLZF1 GORASP1 RAB1A MAPK1 RAB1B USO1 PLK1 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%446652 Interleukin-1 family signaling PTPN18 TBK1 IL36A IL36B IL36G IL13 IL1F10 PSMD12 IL1R1 PSMD11 PSMD14 PSMD13 SMAD2;SMAD3 APP PSMA7 NFKB2 PSMD8 MAP3K3 PSMB6 PSMB7 PSMD6 IL37 CASP1 PSMB4 PSMD7 IL18R1 PSMB5 PSMB2 PSMB3 PSMD2 IL4 PSMD3 PSMB1 PSMD1 IL36RN ADRM1 PSMC2-1 RIPK2 PSMA2-1 PSMA5 IL1RL2 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 TOLLIP PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 PTPN13 IKBKB IKBKG IL1RN IL1R2 UBA52 CUL1 RPS27A UBB;UBC MAP3K7 MAP3K8 GSDMD MAP2K4 MAPK8 TNIP2 IL1RAPL1 PTPN9 PTPN5 PTPN2 UBE2V1 RBX1 STAT3 MAP2K6 IL33 IRAK1 IRAK2 IL1RL1 SQSTM1 UBE2N TAB3 TAB2 TAB1 IL18 IL1A IL1B TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 PTPN11 PTPN6 NFKBIB PTPN20 SAA2;SAA1 PTPN23 NKIRAS1 NKIRAS2 CTSG IKBIP IRAK4 PTPN7 TRAF2 PELI1 PTPN14 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 TIFA HMGB1-1 IL18RAP SIGIRR ALOX5 IRAK3 NFKBIA PTPN12 RELA IL18BP NFKB1 MAP2K2;MAP2K1 PTPN4 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%3232118 SUMOylation of transcription factors PIAS1 TP53BP1 SP3 MTA1 MDM2-2 SUMO1 SUMO3 FOXL2 SUMO2 CDKN2A TP53 PIAS4 PIAS3 UBE2I TFAP2C MITF HIC1 TFAP2E;TFAP2B ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 97%9956514 ARG1 variants cause hyperargininemia ARG1 DEFECTIVE CD320 CAUSES MMATC%REACTOME%R-HSA-3359485.4 Defective CD320 causes MMATC TCN2 CD320 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 97%68877 Mitotic Prometaphase NUP133 NDC80 BUB1 RANGAP1 CLASP2 BUB1B CDC20 CSNK2A1;CSNK2A3 NUMA1 TUBG2 PPP1CC NME7 BUB3 TUBGCP2 MAD2L1 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 SPDL1 NUP43 RANBP2 C1orf112 NSL1 RPS27 YWHAE CEP57 CETN2 NUP37 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG KNL1 ZW10 CDK5RAP2 HSP90AA1 CEP135 CDCA5 PDS5B PDS5A WAPL HAUS4 HAUS3 CSNK1D DSN1 HAUS6 HAUS5 TUBG1 EML4 CKAP5 RCC2 HAUS2 TUBA4A ZWINT HAUS1 XPO1 CEP63 AHCTF1 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CCNB2 CCNB1 HAUS8 PRKAR2B PPP2CB;PPP2CA HAUS7 CEP70 PPP2R5B CEP72 NDEL1 PPP2R5A CEP192 PPP2R5D PPP2R5C PCNT PPP2R1B CEP76 CLASP1 PPP2R5E CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E DYNC1LI1 CEP41 DYNC1LI2 CEP43 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 SMC4 DYNC1I1 SMC2 NCAPG NCAPH NCAPD2 B9D2 SPC24 SPC25 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP KNTC1 CENPA BIRC5 CENPE CENPC SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A CENPT NUP107 CSNK2A2 CENPU CENPF CSNK2B CENPH CENPI TAOK1 CENPK CENPL CENPM NEK9 NEK6 NEK7 CENPO NUP160 CENPP NUP85 CENPQ CLIP1 MAD1L1 ITGB3BP SEC13 NGF PROCESSING%REACTOME DATABASE ID RELEASE 97%167060 NGF processing NGF PCSK6 FURIN PCSK5 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1971475 Glycosaminoglycan-protein linkage region biosynthesis VCAN CSPG5 PXYLP1 B4GALT7 UXS1 DCN GPC1 SDC4 GPC3 B3GAT3 SDC2 GPC2 B3GAT2 SDC3 GPC5 B3GAT1 GPC4 HSPG2 GPC6 BCAN B3GALT6 AGRN XYLT2 SDC1 XYLT1 FAM20B NCAN BGN C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) MUC12 MUC15 MUC3A MUC5AC RELB MUC1 MUC2 CREBBP MUC7 MUC4 MUC6 PSMD12 MUC17 PSMD11 ITPR1 FCER1G PSMD14 ITPR2 MUC5B PSMD13 MUC20 ITPR3 MUC21 PPP3R1 PSMA7 NFKB2 PSMD8 PYCARD PSMB6 PSMB7 PSMD6 NFATC2 PSMB4 PSMD7 NFATC1 PSMB5 PSMB2 PSMB3 PSMD2 PPP3CA PSMD3 PPP3CB PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PRKACA-1 MUC13 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 RAF1 IKBKB IKBKG UBA52 NFATC3 PRKCD CUL1 EP300 MAP3K14 RPS27A RPS6KA5 UBB;UBC MAP3K7 UBE2V1 PAK1 PAK3 PRKACB-1 UBE2N TAB3 TAB2 TAB1 PDPK1 IL1B TRAF6 SYK HRAS CARD9 FYN CLEC4A CLEC4D NRAS CLEC4E CLEC7A CLEC6A PLCG2 CASP8 CALM3;CALM1 CDC34 CARD11 BCL10 UBA3 MALT1 LYN UBE2D3;UBE2D2 ICAM3 NFKBIA PAK2 CLEC4M;CD209-2 UBE2D1 RELA AHCYL1 NFKB1 ICAM2 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H RPL27A EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPS5 RPS6 EIF4G1 RPSA RPL22L1 EIF5 RPL37A-1 RPL26L1 RPL4 RPL30 EIF5B RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 EIF4A2 EIF4A1 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 EIF2S2 EIF4E EIF4B EIF2S3;EIF2S3B EIF2S1 RPL3L RPL5-1 RPLP1-2 RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 97%9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 ABCE1 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi NOTCH1 ST3GAL4 RAB6A FURIN ST3GAL3 LFNG B4GALT1 ATP2A3 ATP2A2 ATP2A1 TMED2-1 MFNG NOTCH2 NOTCH3 NOTCH4 SEL1L RFNG ST3GAL6 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 IL3 LIFR ELF1 CBFB UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME DATABASE ID RELEASE 97%9758881 Uptake of dietary cobalamins into enterocytes PRSS3;PRSS2;PRSS1 TCN1 CBLIF ABCD4 LMBRD1 AMN CTRB1;CTRB2 CUBN DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH GGT1 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA HADHB-1 MECR HADHA HADH ACADM ECHS1 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors PROC F2 F7 GGCX F9 PROS1 F10 GAS6 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts SLC10A1 NR1H4 SLC10A2 RXRA FABP6 SLC27A5 BAAT SLCO1A2 ABCB11 ALB SLC51A SLC51B SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 STARD5 NCOA1 NCOA2 ABCC3 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 97%190236 Signaling by FGFR FGF20 NCBP1 SOS1 FGF23 FLRT2 FLRT3 FLRT1 ANOS1-1 FGF2 KLB FGF19 FGFR4 FGFRL1 POLR2A POLR2B POLR2C POLR2D POLR2G GALNT3 POLR2I NCBP2-1 SPRED2 SPRED1 PLCG1 HRAS PIK3R1 TIAL1 FGF6 PTBP1 MKNK1 RBFOX2 SPRY2 ESRP2 HNRNPH1 NRAS ESRP1 FRS2 HNRNPA1-1 GAB1 TIA1 PPP2R1A PIK3CA HNRNPM PTPN11 POLR2E FGF7 FGFBP1 POLR2F FGFBP3 GTF2F1 POLR2H GTF2F2 FGF22 FGF3 TGFBR3 FGF10 POLR2L GIPC1 UBA52 CBL PPP2CB;PPP2CA HNRNPF POLR2J;POLR2J2;POLR2J3 RPS27A UBB;UBC MAPK1 BRAF MAPK3 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467348 Truncations of AMER1 destabilize the destruction complex PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 97%73943 Reversal of alkylation damage by DNA dioxygenases ALKBH2 FTO ALKBH5 ALKBH3 ASCC1 ASCC2 ASCC3 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors CD70 TNFSF15 TNFRSF9 TNFSF4 TNFSF9 CD27 TNFRSF1A TNFSF8 TNFRSF14 FASLG TNFSF11 TNFSF13B TNFRSF18 EDA TNFRSF13B EDA2R TNFRSF8 TNFRSF4 EDARADD TNFRSF1B EDAR LTA TNFRSF25 TNFRSF11B TNFRSF17 TNFSF18 TNFSF14 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion FARP2 SEMA3A TLN1 RND1 RRAS PLXNA2 PLXNA3 RAC1 FES PIP5K1C NRP1 FYN PLXNA4 PLXNA1 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) SLC6A19 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 97%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853336 Signaling by plasma membrane FGFR1 fusions ERLIN2 BAG4 FGFR1 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB KPNA2 CAMK2G CALM3;CALM1 CAMK4 CAMKK1 CAMK2B CAMKK2 CAMK2D CAMK2A MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 97%453279 Mitotic G1 phase and G1 S transition AKT2 AKT3 FBXO5 CCNA2-1 CCNA1 CCND3 CCND2 PSMD12 PSMD11 PSMD14 CDC25A PSMD13 CDKN2D CDKN2C PRIM2 PRIM1 PSMA7 POLA1 PSMD8 POLA2 MYBL2 PSMB6 PSMB7 PSMD6 E2F4-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 TFDP1 PSMD3 TFDP2 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 E2F1 PSMA2-1 ORC1 CDC7 PSMA5 E2F3 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 PPP2R1A CDC6 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 SKP1 CDKN2B PCNA AKT1 UBA52 CUL1 RPA1 PTK6 RPA2 CCNB1 CDK4 CDK2 PPP2CB;PPP2CA RPA3 RPS27A PPP2R1B UBB;UBC MCM10 DBF4 CDK1 CDK6 ABL1 CDK7 MNAT1 DHFR2;DHFR DYRK1A CKS1B JAK2 PPP2R3B TYMS RBL2 CABLES1 RBL1 WEE1 MYC HDAC1 E2F2 TOP2A RBBP4 MAX CCND1 POLE LIN54 LIN37 LIN9 LIN52 LYN PPP2R2A;PPP2R2D TK1 CDC45 MCM7 MCM8 MCM3 MCM4 MCM5 E2F5 MCM6 E2F6 CDKN2A MCM2 POLE4 RRM2-1 CCNE2 POLE2 CCNE1 RB1 POLE3 CCNH CDKN1C PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 97%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF CAMK2G MARK3 MAP3K11 ARAF KRAS CALM3;CALM1 RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 PEBP1 JAK2 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF PHB MAPK3 KSR1 KSR2 CAMK2B CAMK2D BRAP CAMK2A RAP1B NRAS APBB1IP FORMATION OF THE NEPHRIC DUCT%REACTOME%R-HSA-9830364.1 Formation of the nephric duct OSR1 NPNT PAX2 RET BMP4 PAX8 CTNNB1 GATA3 PCDH19 LHX1 ID4 FGF2 HOXB4 WFDC2 PLAC8 MECOM HOXA6 EMX2 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME%R-HSA-9861559.1 PDH complex synthesizes acetyl-CoA from PYR PDHB PDHX DLD DLAT PDHA1 FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 97%6803529 FGFR2 alternative splicing HNRNPA1-1 TIA1 NCBP1 HNRNPM POLR2E POLR2F POLR2H GTF2F1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I HNRNPF POLR2J;POLR2J2;POLR2J3 NCBP2-1 TIAL1 PTBP1 RBFOX2 ESRP2 HNRNPH1 ESRP1 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9920588.1 Dengue virus activates modulates innate and adaptive immune responses C1S CGAS CTR9 DDX3X-1 APOA1 RTF1 HSP90AA1 CDC73 LEO1 RBM10 CLEC5A C4BPA PAF1 C4BPB VTN IFIH1 LOC110384692;C4A;C4B_2;C4B TRIM25 EXOC1 MAVS HSP90AB1 STAT2 STING1 CLU MBL2-1 WDR61 IKBKE UBR4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) RPS14 NCBP1 RPS17 RPS16 RPS19 RPS18 RPS11 GSPT2 RPL10A GSPT1 RPS10 RPS13 RPS12 UPF2 ETF1 RPL27A RPL10;RPL10L-1 NCBP2-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A PPP2R1A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 PPP2CB;PPP2CA RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 DCP1A EIF4G1 RPSA EIF4A3 CASC3 RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 SMG1 RPL8 RBM8A SMG9 SMG7 RPL9 SMG8 RPL6 SMG5 SMG6 RPL7 UPF1 RPS4X MAGOH;MAGOHB RPL35 RPL38 RPS3A UPF3B RNPS1 RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 PPP2R2A;PPP2R2D RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 97%8978934 Metabolism of cofactors PRKG2 ACO1 COQ3 COQ2 STARD7 PDSS2 PTS HPDL PDSS1 COQ8A NOS3 GCHFR HSP90AA1 SPR CALM3;CALM1 IDH1 DHFR2;DHFR GCH1 COQ9 COQ7 COQ6 AKT1 COQ5 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654732 Negative regulation of FGFR3 signaling FRS2 CBL FGF20 PPP2R1A FGF23 PTPN11 PPP2CB;PPP2CA FGF2 RPS27A UBB;UBC MAPK1 BRAF MAPK3 FGF1 MKNK1 FGF4 SPRY2 FGF16 FGF9 UBA52 FGF18 MRNA CAPPING%REACTOME DATABASE ID RELEASE 97%72086 mRNA Capping RAMAC NCBP1 CDK7 POLR2E POLR2F POLR2H GTF2F1 MNAT1 RNMT GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 RNGTT SUPT5H POLR2J;POLR2J2;POLR2J3 NCBP2-1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 97%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models JUN GOLGA2 CDK5R1 CDC25A CDC25B BCL2L11 APP SOD2 FASLG FOXO3 CDK5 PRDX2 CAPNS1 CAPNS2 PRDX1 LMNB1 YWHAE CAPN2 CAPN1 CAST CDC25C SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-HSA-1660499.8 Synthesis of PIPs at the plasma membrane PIK3R3 PIK3R6 PIK3R5 INPP5D INPP5J INPP5K BMX RUFY1 MTM1 MTMR1 MTMR2 PIP4K2A MTMR3 RAB4A PTEN PIP4K2B PIP4K2C PI4K2B MTMR8 MTMR9 PIP5K1A PIK3CD PIP5K1B PIK3CG SYNJ2 PIP5K1C PIK3R2 SYNJ1 PIK3CB MTMR6 RAB5A PIK3R1 MTMR14 PIK3C2G PLEKHA1 PIK3C2A PI4K2A PLEKHA2 PIK3C2B PLEKHA5 PLEKHA6 PIK3CA PLEKHA3 PLEKHA4 PLEKHA8 ARF1 INPPL1 SBF2 PTPN13 OCRL RAB14 INPP4A INPP4B DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 97%4570571 Defective RFT1 causes CDG-1n RFT1 DEFECTIVE OGG1 LOCALIZATION%REACTOME%R-HSA-9657050.2 Defective OGG1 Localization DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 97%3296482 Defects in vitamin and cofactor metabolism MTR-1 MMADHC MTRR MMAA ABCD4 MMAB MCCC2 MMUT BTD PC CUBN PCCA HLCS MCCC1 TCN2 PCCB CD320 CBLIF ACACA LMBRD1 MMACHC AMN INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection RPS14 RPS17 NUP133 RPS16 RPS19 RPS18 NUP50 GBP2;GBP3;GBP1 POM121;POM121C NUP54 RPS11 RPL10A RPS10 RPS13 RPS12 POLR2A NUP42 POLR2B POLR2C RPL27A POLR2D NUP43 POLR2G POLR2I RAE1 RANBP2 IPO5 GRSF1 MLKL DNAJC3-1 RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 NUP35 RPS21 RPS24 RPS23 RPL36AL-1 RAN SLC25A6 NUP37 RPL7A CPSF4 RPLP0 HSP90AA1 CANX RPLP2 ISG15 RPL36-1 RPL35A RPS27L RPS15A HSPA1A;HSPA1B RPS3 CLTC XPO1 CLTA UBA52 RPS2 NUP214 CALR-1 RPL18A FAU KPNA7 RPL12-1 KPNA5 RPS27A KPNA3 KPNA2 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPL22L1 RPL37A-1 RPL26L1 RPL4 KPNB1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 PARP1 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A KPNA4-1 RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 NUP107 NUP188 RPL15-1 KPNA1 TGFB1 NUP210 POLR2E POLR2F GTF2F1 RPL3L RPL5-1 POLR2H GTF2F2 NUP93 PABPN1-1 POLR2L NUP205 RPLP1-2 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 POLR2J;POLR2J2;POLR2J3 RPL23A EIF2AK2 NUP62 RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 NDC1 RPS15 SEC13 UNC93B1 DEFICIENCY - HSE%REACTOME%R-HSA-5602415.3 UNC93B1 deficiency - HSE UNC93B1 TLR3 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME%R-HSA-9931509.1 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RAI1 ARNTL MEF2D HELZ2 SIRT1 NRIP1 MED1 CRTC1 NPAS2 NR1D1 NCOR1 PPARGC1A TGS1 CREBBP ATF2 RORA RXRA CLOCK CARM1 CHD9 PPARA EP300 TBL1XR1 RORC MEF2C RORB NCOA1 NCOA2 NCOA6 CRTC2 SMARCD3 HDAC3 CRTC3 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69481 G2 M Checkpoints CCNA2-1 CCNA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 PSMD12 KAT5 CHEK2 PSMD11 CHEK1 PSMD14 SFN CDC25A PSMD13 HUS1 PSMA7 PSMD8 PSMB6 DNA2 PSMB7 PSMD6 RHNO1 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ATRIP YWHAE ADRM1 BARD1 ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 ORC1 CDC7 PSMA5 ORC3 SEM1 ORC2 RAD17 PSMA6 ATM PSMC5 CDC6 PSMA3 PSMC6 ATR PSMA4 PSMC3 PSMA1 YWHAG PSMC4 PSMC1 BRCA1 BABAM1 BABAM2 RMI2 UIMC1 YWHAB RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 H2BC5 UBA52 WRN H2BC1 YWHAZ RPA1 HERC2 CCNB2 RPA2 CCNB1 CDK2 RPA3 RPS27A RAD1 UBB;UBC CLSPN MCM10 DBF4 MRE11 NBN CDC25C CDK1 BLM GTSE1 PIAS4 UBE2N RAD9B H2BC21 RAD9A PKMYT1 YWHAQ EXO1 YWHAH TOPBP1 RFC5 RFC3 RFC4 TP53 RFC2 WEE1 UBE2V2 RBBP8 TP53BP1 RAD50 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 H2BC15;H2BC3;H2BC11;H2BC12 CDC45 MCM7 MCM8 NSD2 MCM3 MCM4 MCM5 MCM6 MCM2 BRIP1 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 97%9014826 Interleukin-36 pathway IL36RN IL36G IL1F10 IL36A IL36B IL1RL2 M PHASE%REACTOME DATABASE ID RELEASE 97%68886 M Phase BUB1 CLASP2 BUB1B CDC20 CSNK2A1;CSNK2A3 FBXO5 PPP1CC BUB3 MAD2L1 PSMD12 GOLGA2 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 C1orf112 PSMB6 PSMB7 PSMD6 RPS27 PSMB4 PSMD7 LPIN1 PSMB5 LPIN2 PSMB2 LPIN3 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 YWHAE CEP57 CETN2 ADRM1 CEP164 CCP110 PSMC2-1 AKAP9-1 PSMA2-1 MAPRE1-1 PSMA5 PRKACA-1 SEM1 ACTR1A PSMA6 TUBA1A PSMC5 PPP2R1A PSMA3 LBR CNTRL PSMC6 PSMA4 CEP250 NEK2 PSMC3 PSMA1 CEP290 PSMC4 YWHAG PSMC1 CDK5RAP2 LEMD3 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 XPO1 CEP63 UBA52 PAFAH1B1 TNPO1 NUP214 DYNC1I2 DCTN2 SSNA1 PRKCA DCTN3 CCNB2 CCNB1 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 ANKLE2 KIF20A CEP192 SET-1 RPS27A PCNT CEP76 CLASP1 UBB;UBC CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 PRKCB TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E DYNC1LI1 CEP41 DYNC1LI2 CEP43 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 IST1 SPAST CC2D1B KIF23 NUF2 KIF2A EMD NUDC KIF2C KIF2B INCENP CENPA CENPE CENPC CENPT NUP107 CENPU NUP188 RCC1 BANF1 NUP210 CENPF CENPH GORASP1 CENPI NUP93 TAOK1 CHMP4C CENPK CHMP4B CHMP4A LMNB1 CENPL NUP205 USO1 CENPM NEK9 NEK6 AAAS NEK7 CENPO PPP2R2A;PPP2R2D CENPP NUP160 NUP85 CENPQ TPR NUP88 TUBA1C TUBB1 NUP155 NUP153 CHMP2B CHMP2A TUBB2B;TUBB2A CLIP1 MAD1L1 NUP62 RB1 NDC1 H2AC14 SEC13 TUBB3;TUBB6 TUBAL3 NUP133 NDC80 RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 NUMA1 CHMP7 TUBG2 TUBA3E;TUBA3C-1 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 VPS4A TUBGCP4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SPDL1 NUP42 NUP43 RAE1 RANBP2 TUBA8 H2AC20 H2AB2;H2AB3;H2AB1 NSL1 NUP35 RAB1A RAN RAB1B NUP37 KNL1 ZW10 H2AJ CDCA5 PDS5B PDS5A WAPL ESPL1 DSN1 EML4 RCC2 ZWINT H2BC5 AHCTF1 H2BC1 PPP2CB;PPP2CA PTTG1;PTTG2 PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B H2AC4 PPP2R5E KMT5A VRK1 LEMD2 CTDNEP1 CNEP1R1 RAB2A GORASP2 BLZF1 SMC4 DYNC1I1 SMC2 NCAPG NCAPH NCAPD2 KPNB1 UBE2I B9D2 H2BC21 SPC24 SPC25 ERCC6L ARPP19 NCAPH2 SUMO1 NCAPG2 ZWILCH NIPBL ENSA SIRT2 NCAPD3 PMF1;PMF1-BGLAP H2AZ2;H2AZ1 MAU2 MASTL MCPH1 KNTC1 BIRC5 SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A CSNK2A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B H2BC15;H2BC3;H2BC11;H2BC12 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 MAPK1 ANAPC5 ANAPC1 ANAPC2 ITGB3BP VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296072 Voltage gated Potassium channels KCNH4 KCNH5 KCNH6 KCNS3 KCNH7 KCNH8 KCNB2 KCNAB1 KCNAB2 KCNAB3 KCNQ2 KCNS1 KCNQ3 KCNS2 KCNA10 KCNQ5 KCNQ4 KCND1 KCNQ1 KCND2 KCND3 KCNB1 KCNG1 KCNG3 KCNG4 KCNC1 KCNA1 KCNG2 KCNC3 KCNA2 KCNC4 KCNA3 KCNA5 KCNA4 KCNA6 KCNC2 KCNA7 KCNV1 KCNH2 KCNV2 KCNH1 KCNF1 KCNH3 MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 97%912446 Meiotic recombination ATM RAD50 BLM SPO11 BRCA1 PRDM7;PRDM9 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MSH4 MSH5 DMC1 PSMC3IP RAD51 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TOP3A MND1 MLH3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 RAD51C RPA1 RPA2 MLH1 CDK4 H2AC20 CDK2 C1orf112 H2AB2;H2AB3;H2AB1 BRCA2 H2AZ2;H2AZ1 RPA3 FIGNL1 H2AC4 MRE11 NBN RBBP8 H2AC14 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 97%480985 Synthesis of dolichyl-phosphate-glucose ALG5 NUDT14 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933947 Formation of the non-canonical BAF (ncBAF) complex ACTL6A BCL7C SMARCA2 BCL7B SMARCA4 SMARCC1 SMARCC2 BICRAL BICRA ACTB-1 BRD9 SMARCD1 SMARCD2 SS18 BCL7A SMARCD3 SS18L1 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 97%9726840 SHOC2 M1731 mutant abolishes MRAS complex function ARAF MRAS RAF1 YWHAB BRAF SHOC2 PPP1CB PPP1CC MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins PPP1CA FURIN CSNK2A2 CSNK2A1;CSNK2A3 PPP1CC CSNK2B SPCS3 SPCS2 SPCS1 KPNB1 SEC11A SEC11C XPO1 PPP1CB INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963676 Intestinal absorption RSC1A1 SLC2A5 SLC5A1-1 SLC2A2 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) SNAP25 SV2B SV2A ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 97%442755 Activation of NMDA receptors and postsynaptic events PRKAR1B PRKAR1A GRIN2A RASGRF2 GRIN2B GRIN1 ADCY1 ADCY8 APBA1 PRKAB2 PRKACB-1 PRKAR2A CAMK4 PRKAB1 PDPK1 CAMK1 SRC CAMKK1 GRIA1 CAMKK2 GRIA3 GRIA4 DLG1 HRAS PRKAA1 CAMK2B CAMK2D CAMK2A PRKAG2 NRAS PRKACA-1 KIF17 CAMK2G PRKAA2 PRKAG1 GRIA2 RAC1 PRKAG3 NRG1 CALM3;CALM1 RPS6KA6 ACTN2 CASK LIN7A LIN7C GRIN2C GRIN2D GRIN3B GRIN3A DLG2 DLG3 DLG4 NBEA RASGRF1 PRKAR2B GIT1 NRGN RPS6KA3 RPS6KA2 NEFL KPNA2 RPS6KA1 LRRC7 PRKX LIN7B MAPK1 PPM1E PPM1F MAPK3 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME%R-HSA-8950505.5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CA1 ARF1 RPLP0 GSTO1 GSTA3;GSTA5;GSTA1;GSTA2 PITPNA LMNB1 CNN2 HNRNPDL AIP CFL1 STAT4 HSPA9 PAK2 IL10 SERPINB2 ANXA2 MSN MIF RALA-1 SOD2 TALDO1 SOD1 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 CDC42 LCP1 PPIA MTAP TCP1 CAPZA1 RAP1B NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 97%164940 Nef mediated downregulation of MHC class I complex cell surface expression AP1G1 AP1S2 PACS1 AP1S1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E AP1S3 AP1M2 AP1B1 AP1M1 B2M SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 97%4839744 Signaling by APC mutants PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME DATABASE ID RELEASE 97%9667769 Acetylcholine inhibits contraction of outer hair cells KCNMB1 KCNMA1 CHRNA9 CHRNA10 KCNN2 RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%611105 Respiratory electron transport TIMMDC1 ETFDH NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 NDUFAF1 SURF1 NDUFS5-1 COX7B COX7C SCO1 UQCRC1 UQCRC2 COX8A SCO2 COX8C HSCB TMEM126B COA3 COX5B ACAD9 COX5A SFXN4 NUBPL COX6C NDUFAB1 COA5 TACO1 ECSIT COX6A1 COX6A2 COQ10A-1 SDHC SDHD SDHA COX6B2 SDHB CYC1 COX6B1 NDUFV3 NDUFV2 NDUFV1 COX19 GOT2-1 NDUFB10 DMAC2 COX15 NDUFB11 COX18 PET117 COX17 CMC1 CYCS-1 HIGD1A UQCRFS1 COX11 COX14 MDH1 HIGD2A MDH2 NDUFS8 NDUFS7 NDUFS6 SMIM4 COX20 LETM1 NDUFS4 NDUFS3 LYRM2 NDUFS2 TMEM223 NDUFS1 LYRM4 LYRM7 UQCRB NDUFC2;NDUFC2-KCTD14 C12orf73 TRAP1 GOT1-1 HCCS UQCRQ TTC19 ETFA COX4I1 ETFB COX4I2 NDUFC1 SLC25A18 COX7A2L-1 FXN UQCR11 NDUFA13 SLC25A12 SMIM20 UQCR10 NDUFA11 NDUFA12 SLC25A11 NDUFA10 SLC25A13 NDUFB9 NDUFB8 NDUFB7 NDUFB6 FOXRED1 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 UQCC3 OXA1L UQCC2 UQCC1 COX7A2 HSPA9 TMEM186 TMEM126A-1 SLC25A22 NDUFA9 NDUFA8 NDUFA7 RAB5IF NDUFA6 TIMM21 BCS1L COQ10B NDUFA4 TMEM177 NDUFA3 PYURF HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.5 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) CCNA2-1 CCNA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 KAT5 POLH CHEK1 HUS1 MUS81 C1orf112 EME1-1 BRCA2 DNA2 RAD51AP1 RHNO1 SLX4 EME2 FIGNL1 GEN1 XRCC2 XRCC3 SIRT6 PALB2 SPIDR SLX1A;SLX1B ATRIP BARD1 SEM1 RAD17 ATM ATR BRCA1 BABAM1 BABAM2 RMI2 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 RAD51D H2BC5 PCNA UBA52 WRN H2BC1 RPA1 HERC2 RPA2 CDK2 RPA3 RPS27A RAD1 UBB;UBC CLSPN MRE11 NBN RTEL1 ABL1 BLM PIAS4 RAD51 UBE2I POLD1 UBE2N RAD9B H2BC21 RAD9A RAD51B RAD51C EXO1 SUMO2 TOPBP1 RFC5 RFC3 RFC4 RFC2 UBE2V2 RBBP8 TP53BP1 RAD50 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LIG1 RNF168-1 PPP4R2 TIPIN TIMELESS PPP4C POLK RAD52 POLE RFC1 H2BC15;H2BC3;H2BC11;H2BC12 NSD2 POLD3 POLD4 POLD2 POLE4 BRIP1 ERCC4 POLE2 RNF4 ERCC1 POLE3 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation HOXC4 HOXA2 PBX1 PAXIP1 CNOT6 YY1 DPY30 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B PAGR1 POLR2C PAX6 CREBBP POLR2D CTCF H2BC21 POLR2G POLR2I CNOT9 WDR5 RXRA KDM6A H2AC20 EED RARA H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EZH2 HOXB4 ASH2L NCOA6 NCOA3 HDAC3 JUN RARG RBBP4 RBBP5 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 POLR2E RARB POLR2F POLR2H RBBP7 HOXA3 POLR2L HOXA1 PKNOX1 HOXA4 PIAS2 HOXB3 H2BC15;H2BC3;H2BC11;H2BC12 HOXB2 SUZ12 HOXB1 H2BC5 AJUBA HOXD1 PCGF2 MEIS1 H2BC1 MAFB HOXD4 HOXD3 ZNF335 POLR2J;POLR2J2;POLR2J3 EP300 EGR2 H2AC4 KMT2D KMT2C H2AC14 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 97%9851151 MDK and PTN in ALK signaling ALK PTN PTPRZ1 MDK SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 97%6802952 Signaling by BRAF and RAF1 fusions BCL2L11 MARK3 TRAK1 FXR1-1 FAM114A2 KDM7A JAK2 AGK CLCN6 VCL TLN1 ZC3HAV1 SRC FN1 IQGAP1 LMNA ARRB2 FAM131B CSK HRAS CAMK2B AKAP9-1 CAMK2D CAMK2A KIAA1549 RAP1B NRAS ESRP1 CAMK2G TRIM24 ARAF CALM3;CALM1 MPRIP AGTRAP RAF1 CNKSR2 YWHAB ITGB3 SND1 CNKSR1 AGGF1 PEBP1 FGB FGA ARRB1 FGG ITGA2B TENT4A VWF AP3B1 MAP2K2;MAP2K1 QKI PAPSS1 RAP1A MAPK1 ATG7 BRAF KSR1 MAPK3 KSR2 APBB1IP SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 97%5340588 Signaling by RNF43 mutants RNF43 WNT3A FZD5 FZD4 FZD6 LRP5 FZD8 LRP6 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 97%442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling CAMK2G RASGRF2 GRIN2B CALM3;CALM1 GRIN1 RPS6KA6 ACTN2 GRIN2D DLG2 DLG3 DLG4 RASGRF1 PDPK1 RPS6KA3 RPS6KA2 NEFL RPS6KA1 DLG1 LRRC7 MAPK1 HRAS MAPK3 CAMK2B CAMK2D CAMK2A NRAS NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 97%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TXN UBE2V1 BCL2 MAP2K6 BCL2L1 IRAK1 IRAK2 NLRP3 UBE2N TAB3 CASP5;CASP4 MAPK13 TAB2 TAB1 HSP90AB1 ITCH APP NLRC4 MEFV NFKB2 PANX1 PYCARD CASP2 P2RX7 PSTPIP1 AIM2 CASP1 TXNIP TRAF6 NLRP1 SUGT1 CARD9 NOD1 NOD2 RIPK2 AAMP TNFAIP3 CYLD HMOX1 BIRC2 CHUK BIRC3 CASP8 IKBKB IKBKG RELA NFKB1 MAP3K7 CASP9 MAPK14 MAPK11 MAPK12 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 97%2395516 Electron transport from NADPH to Ferredoxin FDXR FDX1 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 97%1606322 ZBP1(DAI) mediated induction of type I IFNs RIPK3 TBK1 MYD88 NFKBIB RELA NKIRAS1 TLR3 NKIRAS2 NFKB2 CHUK TICAM1 IRF3 DHX9 RIPK1 NFKB1 IKBKB NLRP4 IKBKG ZBP1 NFKBIA DTX4 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9824594 Regulation of MITF-M-dependent genes involved in apoptosis HDAC1 POU3F2 DICER1 BIRC7 TNRC6C MOV10 TNRC6A-1 AGO4 BCL2 AGO2 BCL2A1 AGO3;AGO1 TNRC6B TRPM1 HINT1 SIN3A STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants GRB2 PTPN11 NOX4 STAT5A CDKN1A STAT5B GAB2 FLT3 PIM1 BCL2L1 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.5 PKMTs methylate histone lysines SMYD2-1 RBBP4 RBBP5 SMYD3 PRDM7;PRDM9 AEBP2 RBBP7 PRDM16 MECOM SUV39H2 SETD2 DPY30 ATF7IP SETD3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SETD6 SETD7 SUZ12 SETDB1 SETD1B SETD1A ASH1L WDR5 DOT1L RELA NSD3 NSD1 NFKB2 NSD2 EED EZH2 SUV39H1 ASH2L NFKB1 KMT5A KMT2D KMT5B EHMT2 KMT2A EHMT1 KMT2C KMT2B KMT5C DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME%R-HSA-9938206.2 Developmental Lineage of Mammary Stem Cells FGF10 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432720 Lysosome Vesicle Biogenesis GNS AP4B1 ARF1 HGS CLTC CTSZ CLTA AP4E1 ARRB1 AP4M1 AP1G2 AP1G1 DNASE2 CLVS2 AP1S2 DNM2 VAMP2 AP1S1 AP4S1 APP AP1S3 CLVS1 SH3GL2 AP1B1 VAMP7 VAMP8 DNAJC6 M6PR CHMP2A CLTB BLOC1S1 HSPA8 AP1M2 TXNDC5 AP1M1 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037628.2 Rhesus blood group biosynthesis CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine ACSM1 GLYATL3 ACSM2A;ACSM2B GLYAT CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 97%4086398 Ca2+ pathway GNG10 GNG2 GNG5 GNG4 GNG8 WNT11 GNG13 GNB2 GNB1 GNAT2 GNB4 GNB3 ITPR1 WNT5A ITPR2 GNB5 LEF1 ITPR3 NLK PPP3R1 FZD3 FZD2 FZD5 FZD4 FZD6 NFATC1 GNAO1 PPP3CA PPP3CB PRKG1 PDE6B PDE6A CAMK2A PRKG2 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 CTNNB1 TNRC6B TCF7 CALM3;CALM1 TCF7L1 GNGT1 PRKCA PLCB3 TCF7L2 PLCB1 PLCB2 MAP3K7 B CELL ACTIVATION%REACTOME%R-HSA-983705.3 B Cell Activation SOS1 CD19 CD22 NCK1 PIK3AP1 PSMD12 PSMD11 ITPR1 PSMD14 ITPR2 PSMD13 ITPR3 PPP3R1 PSMA7 CD79B PSMD8 CD79A PSMB6 FKBP1A PSMB7 PSMD6 PSMB4 NFATC2 PSMD7 PPIA NFATC1 PIK3CD PSMB5 SYK PSMB2 PSMB3 PPP3CA PSMD2 PPP3CB PSMD3 PSMB1 PSMD1 HRAS PIK3R1 FYN ADRM1 TRPC1 PSMC2-1 PSMA2-1 PSMA5 NRAS SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PTPN6 PSMA4 NFKBIB BTRC PSMC3 PSMA1 BLK PSMC4 PSMC1 SKP1 PLCG2 BLNK CHUK BTK DAPP1 REL FBXW11 CALM3;CALM1 RASGRP3 NFKBIE IKBKB CARD11 BCL10 IKBKG RASGRP1 MALT1 LYN UBA52 NFKBIA NFATC3 STIM1 CUL1 ORAI2 RELA ORAI1 SH3KBP1 RPS27A AHCYL1 UBB;UBC NFKB1 MAP3K7 VAV1 PRKCB SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 97%8851708 Signaling by FGFR2 IIIa TM NCBP1 POLR2I FGFR2 POLR2J;POLR2J2;POLR2J3 NCBP2-1 FGF2 POLR2E POLR2F GTF2F1 POLR2H GTF2F2 POLR2L POLR2A POLR2B FGF1 POLR2C POLR2D POLR2G REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2R1B PPP2R1A PFKFB2 PFKFB1 PFKFB4 PRKACB-1 PFKFB3 PPP2CB;PPP2CA PPP2R5D PRKACA-1 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 CYP2U1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity TGIF1-1 HDAC1 SNW1 UBE2D3-1 USP9X NCOR2 WWTR1 NCOR1 NEDD4L UBA52 PARP1 SMAD2;SMAD3 UBE2D1 PPM1A ATP1B4 TGIF2 SKI RPS27A SMAD4 SMURF2 UBB;UBC SMAD7 RNF111 MAPK1 MAPK3 SKIL TRIM33 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition PLK1 FBXO5 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296346 Tandem pore domain potassium channels KCNK9 KCNK10 KCNK3 KCNK6 KCNK13 KCNK7 KCNK16 KCNK1 KCNK18-1 KCNK17 KCNK2 KCNK4 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation TYK2 IL6 MAP2K2;MAP2K1 PTPN11 MAPK1 JAK1 JAK2 IL6R TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 97%420029 Tight junction interactions CLDN20 CLDN11 CLDN10 CLDN15 CLDN14 CLDN12 CLDN19 CLDN5 CLDN18 CLDN17 CLDN16 CLDN1 CLDN22;CLDN24-1 PARD6G MPP5 F11R PARD3 PARD6B CRB3 PARD6A PRKCI CLDN2 CLDN6 CLDN4 CLDN3 CLDN9 CLDN8 CLDN7 PATJ CLDN23-1 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling NGF SMPD2 NGFR RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.9 RHO GTPases Activate NADPH Oxidases S100A8 NCF1 PRKCD PRKCA NCF2 NCF4 NOXO1 RAC1 NOXA1 PRKCZ PIK3C3 CYBB MAPK14 MAPK1 CYBA MAPK11 NOX3 MAPK3 NOX1 PRKCB PIN1 PIK3R4 S100A9 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability CTNND1 MTOR AKT2 NOS3 AKT3 CTNNB1 PAK1 RAC1 HSP90AA1 CTNNA1 PAK3 CALM3;CALM1 JUP CAV1 AKT1 PAK2 THEM4 RICTOR PRR5 CDH5 PDPK1 MLST8 VAV3 TRIB3 MAPKAP1 VAV1 VAV2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 97%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein DPM1 DPM2 MVD DPM3 ST8SIA5 ST6GAL1 CTSA DPAGT1 MPI ST3GAL4 ST6GALNAC2 DOLK ST3GAL1 ST3GAL2 ST3GAL3 SLC35A1 SRD5A3 SLC35C1 ST6GALNAC1 CMAS NPL NANP ST6GALNAC3 ST6GALNAC4 NEU4 NAGK AMDHD2 ST8SIA4 NANS GFPT2 ST6GAL2 GFPT1 PGM3 ST8SIA1 GNPNAT1 ALG14 GNE ALG12 UAP1 ALG11 RENBP ST3GAL6 ST6GALNAC5 GLB1 ST6GALNAC6 ALG8 ST3GAL5 ALG9 ALG6 ALG5 ALG2 NUDT14 ALG3 ALG1 RFT1 MPDU1 DHDDS PMM2 GMPPB FPGT GMPPA GFUS DHRSX GMDS ST8SIA6 NUS1 PMM1 ST8SIA2 FCSK DOLPP1 ST8SIA3 ALG10;ALG10B HK1 NEU2 NEU3 SLC17A5 NEU1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism DLD BCAT2 ALDH6A1 MCCC2 GLYAT ECHS1 IVD ACAD8 MCCC1 SLC25A44 CRAT BCKDHA PPM1K DBT BCKDHB ACADSB HSD17B10 HIBADH BCKDK HIBCH ACAT1 BCAT1 AUH CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants RBX1 CDK8 DLL4 PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 HDAC8 JAG1 ADAM10 HDAC9 NOTCH1 HDAC6 ADAM17 HDAC7 RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN NEURL1B MAML3 MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 UBA52 CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ALDOB ALDH1A1 KHK TKFC GLYCTK ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 97%3371568 Attenuation phase HSP90AB1 DNAJB1 HSPA1L HSBP1 HSF1 HSP90AA1 EP300 PTGES3-1 HSPA8 HSPA1A;HSPA1B HSPA2 CREBBP FKBP4 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932505 DAG1 core M3 glycosylations POMT2 POMK POMGNT2 DAG1 B3GALNT2-2 POMT1 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 97%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) GATA3 HDAC11 BMI1 ETS1 YY1 IL4R HDAC4 DPY30 KLF13 CHD4 RING1 CHD3 IL13 MAF IRF4 CREBBP HDAC5 HDAC8 SATB1 HDAC9 NOTCH1 RNF2 HDAC6 HDAC7 STAT6 SMARCA4 RBPJ WDR5 CBX8 STAT5A STAT5B CBX6 PHC2 PHC1 POU2F1 CBX4 MAML2 CBX2 MAML1 NFATC2 ASH2L POU2F2 PHC3 BATF IL4 IL5 MAML3 NOTCH2 HDAC2 HDAC3 HDAC1 JUN SNW1 MAMLD1 MTA1 HDAC10 RBBP4 NCOR2 RBBP5 KAT2B KAT2A NCOR1 RBBP7 MTA2 MTA3 FOS MBD3 GATAD2B GATAD2A EP300 MEN1 TBL1XR1 KMT2A MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination MRPS17 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPS36 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 OXA1L AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 GFM2 MRPL27 MTRF1 MRPL28 MTRF1L ERAL1 MRRF MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 ASSEMBLY OF THE 9+2 MOTILE CILIA%REACTOME DATABASE ID RELEASE 97%9975924 Assembly of the 9+2 motile cilia RFX2 RFX3 CCNO TNRC6C MOV10 TP73 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 GRHL3 TNRC6B GRHL2 DEUP1 GMNC FOXJ1 MYB NOTCH1 DLL1 E2F4-1 E2F5 TFDP1 GMNN GRHL1 MCIDAS DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 97%9927426 Developmental Lineage of Mammary Gland Alveolar Cells PRL FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 97%9617828 FOXO-mediated transcription of cell cycle genes SMAD2;SMAD3 BTG1 FOXG1 CDKN1A CDKN1B FOXO4 FOXO3 SMAD4 MSTN FOXO1-1 KLF4 PCBP4 RBL2 CAV1 CCNG2 GADD45A SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks KAT5 ATM KPNA2 RAD50 MRE11 NBN SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE PCYT2 CHKB ETNPPL CHKA PISD ETNK2 ETNK1 PHOSPHO1 LPIN1 LPIN2 SELENOI LPIN3 CEPT1 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic COG4 RAB33B-1 STX5 COG3 YKT6 COG2 RGP1 BET1L RAB30 RAB36 ARF1 VPS45 TRIP11 ALPG;ALPP;ALPI-1 MAN2A1 GOSR2 NAPB MAN1A2 MAN1C1 NAPG MAN1A1 RAB39A COG1 MAN2A2 NAPA NSF STX16 GOSR1 GOLIM4 CYTH3 CYTH2 GOLGA5 CYTH4 CUX1 STX6 VTI1A CYTH1 COG8 COG7 RIC1 COG6 SNAP29 COG5 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 97%111463 SMAC (DIABLO) binds to IAPs APAF1 CASP3 DIABLO-1 CASP9 CASP7 CYCS-1 XIAP ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2468052 Establishment of Sister Chromatid Cohesion PDS5A STAG2 WAPL SMC1A ESCO1 ESCO2 SMC3 RAD21 CDCA5 STAG1 PDS5B FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654700 FRS-mediated FGFR2 signaling FRS2 FGF20 SOS1 FGF23 PTPN11 FGF2 FGF7 FGF22 FGF3 FGF10 HRAS FGF1 FGF6 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-HSA-72202.4 Transport of Mature Transcript to Cytoplasm NCBP1 NUP133 NXT1 U2AF1L5;U2AF1 EIF4A3 CASC3 NUP50 GLE1 POM121;POM121C NXF2;NXF2B;NXF5-1 THOC1 NUP54 THOC3 THOC2 THOC5 SYMPK CDC40 THOC7 THOC6 SRRM1 DDX39A DDX39B SARNP ZC3H11A SRSF2 FIP1L1 SRSF3 NUP42 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 RBM8A NUP43 POLDIP3 SRSF1 NXF1 SLBP U2AF2 RAE1 FYTTD1-1 RANBP2 DHX38 SRSF11 MAGOH;MAGOHB SRSF4-1 CHTOP ALYREF UPF3B RNPS1 NCBP2-1 CPSF2-1 NUP35 NUP37 CPSF4 CPSF1 CPSF3 NUP107 NUP188 EIF4E NUP210 NUP93 NUP205 AAAS NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 NUP62 WDR33 NDC1 SEC13 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME%R-HSA-9648895.4 Response of EIF2AK1 (HRI) to heme deficiency EIF2AK1 CEBPB ATF4 GRB10 CHAC1 DDIT3 EIF2S2 ATF3 EIF2S3;EIF2S3B TRIB3 EIF2S1 ASNS CEBPG PPP1R15A ATF5 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME DATABASE ID RELEASE 97%180910 Vpr-mediated nuclear import of PICs NUP133 NUP107 NUP188 NUP50 POM121;POM121C BANF1 NUP54 KPNA1 NUP210 NUP93 PSIP1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants KIT PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.5 Phase 0 - rapid depolarisation SCN1A CAMK2G FGF14 FGF13 FGF12 FGF11 SCN3B SCN3A CALM3;CALM1 SCN2A CACNG6 SCN2B RANGRF CACNG8 CACNB2 CACNA2D2 SCN9A CACNG4 SCN8A SCN11A SCN10A SCN5A CACNA1C SCN4A SCN4B SCN7A CACNG7 CAMK2B CACNB1 CAMK2D CAMK2A SCN1B NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9026357.2 NTF4 activates NTRK2 (TRKB) signaling NTRK2 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME DATABASE ID RELEASE 97%9672383 Defective factor IX causes thrombophilia F8 F9 F10 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) IDUA RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 97%73772 RNA Polymerase I Promoter Escape TAF1D TAF1B RRN3 TAF1C H2AJ TAF1A CDK7 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H MNAT1 POLR2L H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 ERCC3 H2BC21 H2BC1 ERCC2 GTF2H1 GTF2H3 UBTF GTF2H4 H2AC20 PHF6 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CBX3-1 POLR1A POLR1B POLR1C H2AC4 POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 CCNH H2AC14 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A IRAK1 RECRUITS IKK COMPLEX%REACTOME%R-HSA-937039.3 IRAK1 recruits IKK complex TRAF6 IKBKB UBE2V1 IKBKG PELI1 CHUK UBE2N IRAK1 PELI3 PELI2 CHD CHROMATIN REMODELERS%REACTOME%R-HSA-9937848.1 CHD chromatin remodelers PHF5A SNRPD2 SNRPD1 SNRPN SNRPD3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP SNRPE-2 H2AC20 H2AB2;H2AB3;H2AB1 SSRP1 CBX3-1 MAFK NFE2L2 CTNNB1 H2AJ CDC73 TCF12 LEO1 AXIN2 SF3B1 MBD3 H2BC5 MBD2 H2BC1 GATAD2B GATAD2A CHD9 EP300 H2AC4 CHD2 TCF4 SNRPF SNRPB CTR9 RTF1 MYOG PAF1 FBP1 DHX15 MYOD1 UBE2I CHD4 G6PC1 CHD3 CHD8 CHD7 CHD6 CTCF H2BC21 NKD2 FAM124B IGF2 PWWP2B DDX46 DDX42 CHD5 IKZF1 WDR5 IKZF2 SUMO1 RBM17 IKZF3 PHF6 MBD3L1 ZMYND8-1 PWWP2A H2AZ2;H2AZ1 ADNP2 ZNF687 TCF19 ADNP ZNF592 ZNF827 SMNDC1 CBX1 U2SURP NR2F2 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 CDK2AP2 CDK2AP1 ZNF532 DKK2 SNRPG-2 HDAC2 NR2C2 HDAC1 SF3B4 SF3B5 MTA1 SF3B2 SF3B3 RBBP4 NQO1 SF3B6 SF3A3 SF3A1 SUPT16H H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SF3A2 RBBP7 MTA2 MTA3 CHERP H2BC15;H2BC3;H2BC11;H2BC12 PUF60 SNRPB2 SNRPA1 WDR61 PCK1 H2AC14 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma ALB HBA2;HBA1 CD163 HPX APOL3;APOL4;APOL1;APOL2 APOA1 AMBP LRP1 JCHAIN HP;HPR HBD;HBB HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC PLA2G4A PLBD1 GPCPD1 PLA2G15 PLA2G4F JMJD7-PLA2G4B;PLA2G4B PLA2G4D PLA2G4E LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.2 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling NOTCH1 CUL1 RBX1 SKP1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4EBP1 EIF4H RPL27A EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RPL22L1 EIF5 RPL37A-1 RPL26L1 RPL4 RPL30 EIF5B RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 EIF4A2 EIF4A1 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF4E EIF4B EIF2S3;EIF2S3B EIF2B1 EIF2S1 RPL3L RPL5-1 RPLP1-2 RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 97%9909615 Regulation of PD-L1(CD274) Post-translational modification RBX1 CSNK2A1;CSNK2A3 GSK3B DERL3 OST4 DERL1 SPOP PRKAB2 RPN2 OSTC STT3A RPN1 STT3B PSMD12 PSMD11 PSMD14 PSMD13 PRKAB1 PSMA7 PSMD8 DDOST PSMB6 PSMB7 PSMD6 DAD1 PSMB4 PSMD7 ERLEC1 PSMB5 CD274 PSMB2 PSMB3 PSMD2 PSMD3 B3GNT3 PSMB1 MAGT1 PSMD1 JAK1 PRKAA1 ADRM1 CUL3 SEL1L PSMC2-1 PSMA2-1 PRKAG2 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 MIB2 BTRC CSNK2A2 PSMC3 PDCD1 PSMA1 PRKAA2 YWHAG PSMC4 PRKAG1 PSMC1 SKP1 PRKAG3 CCND1 CSNK2B UBA52 ERLIN1 ERLIN2 CUL1 CDK4 PDCD1LG2 VCP-1 RPS27A TUSC3 DERL2 RNF5 UBB;UBC OS9 COPS5 RNF185 TMEM258 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration RHOA MET RND1 RRAS ARHGAP35 RAC1 SEMA4D PLXNB1 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9028335 Activated NTRK2 signals through PI3K BDNF GAB1 PIK3CA PIK3R1 NTRK2 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins SCN1A SPTBN2 ANK2 KCNQ2 KCNQ3 SPTBN4 SPTBN5 ANK1 SCN3B SCN3A SCN2A SCN2B SPTBN1 SCN9A NRCAM SCN8A SPTA1 SCN11A SCN10A SPTAN1 L1CAM SCN5A SCN4A SCN4B SPTB SCN7A ANK3 NFASC SCN1B RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013420 RHOU GTPase cycle WDR6 ARHGEF7 SRGAP2 PTK2B DST ARHGEF6 USP9X TXNL1 WWP2 PAK1 VANGL1 PAK3 DEPDC1B HGS MYO6 PAK4 GIT2 DLG5 NCK2 SPTBN1 NCK1 STAM EPHA2 CLTC ARHGAP31 PAK2 ARHGAP30 ITSN2 SRC SPTAN1 GIT1 CDC42 PARD6A IQGAP1 PIK3R2 PIK3R1 PEAK1 STAM2 RHOU ION HOMEOSTASIS%REACTOME%R-HSA-5578775.4 Ion homeostasis TRDN ASPH NOS1 ATP1A4 ATP1A3 ABCC9 ATP1A2 ATP1A1 TNNI3 ATP1B3-1 FXYD2;FXYD6-FXYD2 ITPR1 ITPR2 ITPR3 FKBP1B CAMK2B TRPC1 CAMK2D CAMK2A PRKACA-1 CAMK2G SLC8A3 ATP2B4 ATP2A3 ATP1B2 ATP2B3 ATP2A2 ATP1B1 KCNJ11 ATP2B2 ATP2A1 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 STIM1 ORAI2 ORAI1 DMPK AHCYL1 FXYD4 FXYD3 FXYD1 FXYD6 RYR1 RYR2 RYR3 CLIC2 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) IDS MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 97%936440 Negative regulators of RIG-I MDA5 signaling TNFAIP3 TBK1 UBE2D3-1 CYLD UBA7 PCBP2 DDX58 NLRC5 ISG15 UBE2L6 HERC5 RNF135 IFIH1 OTUD5 TRIM25 MAVS UBE2D3;UBE2D2 PIN1 UBA52 UBE2K ITCH UBE2D1 TAX1BP1 RNF125 RNF216 IRF3 RPS27A TRAF3 ATG12-1 UBB;UBC ATG5 IKBKE NLRX1 FIBRIN FORMATION%REACTOME%R-HSA-9769733.1 Fibrin formation FGG F2 ITGA2B SERPINC1 SERPIND1 PROC F13B SERPINE2 ITGB3 F13A1 SERPINA5 FGB FGA PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism PCCB MCEE MMAA MMUT PCCA CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022870 CS-GAG biosynthesis BCAN VCAN CHST11 CHST3 CHST12 CHPF2 CHSY3 CHST15 CSPG5 CHST7 CHSY1-1 UST CHST13 CHPF CSGALNACT1 DCN CSGALNACT2 NCAN BGN DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation MET HGF PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 CDK1 CCNB1 FZR1 PLK1 CDC20 FBXO5 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery CCNK CCNT1 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I SUPT4H1-1 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB NELFCD NELFA NELFE ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 97%9659787 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CDK6 E2F2 CDKN1A CDKN1B CDK4 CDK2 CCND1 TFDP1 TFDP2 CCNE2 CCNE1 RB1 CDKN1C CCND3 E2F1 CCND2 E2F3 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 97%2142770 Synthesis of 15-eicosatetraenoic acid derivatives GPX4 PTGS2-2 ALOX15B GPX1 ALOX15 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade CLEC1B PIK3CA PTPN11 PTPN6 PIK3R3 PIK3R6 PIK3R5 PLCG2 RAC1 PRKCZ PDPN MPIG6B GP6 LCP2 RHOA LYN FCER1G LCK PDPK1 VAV3 LAT CDC42 RHOG PIK3CG SYK PIK3R2 PIK3CB VAV1 VAV2 PIK3R1 RHOB FYN CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%420499 Class C 3 (Metabotropic glutamate pheromone receptors) CASR GRM8 TAS2R7 GABBR2 TAS2R8 TAS2R42 GABBR1 TAS2R3-1 GRM4 GPRC6A TAS2R1 TAS2R4 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GRM1 TAS2R16 GRM5 TAS2R40 TAS2R41 PRH1-TAS2R14;TAS2R14-3 TAS1R2 TAS1R1 TAS2R39 TAS1R3 GRM3 GRM2 GRM7 GRM6 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-HSA-157858.3 Gap junction trafficking and regulation GJA1 GJC1 GJB2 GJC2 GJB1 GJA3 MYO6 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJD4 GJD3 GJB4 CLTC GJB3 CLTA GJB6 GJB5 GJB7 DNM1 DNM2 TJP1 CLTB DAB2 CLTCL1 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68867.10 Assembly of the pre-replicative complex KPNB1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC21 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 H2AC20 PSMD8 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 PSMA5 ORC1 ORC3 SEM1 PSMA6 ORC2 CDT1 PSMC5 PSMA3 CDC6 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 H2AJ KPNA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 UBA52 H2BC1 ANAPC15 ANAPC16 UBE2D1 ANAPC10 MCM7 ANAPC11 MCM8 FZR1 CDC23 CDC26 CDC27 MCM3 MCM4 ANAPC7 MCM5 RPS27A MCM6 MCM2 UBE2C UBE2E1 H2AC4 UBB;UBC KPNA6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 H2AC14 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription TGIF1-1 HDAC1 CCNK CCNT1 CDK8 WWTR1 COL1A2 CCNC-1 CDKN2B SP1 UBA52 SMAD2;SMAD3 FURIN CDK9 TGIF2 EP300 CCNT2-1 E2F4-1 RPS27A E2F5 SMAD4 MEN1 UBB;UBC SERPINE1 TFDP1 JUNB SMAD7 RNF111 TFDP2 MAPK1 RBL1 MAPK3 YBX1 MYC MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation CDK1 TYK2 IL6 MAP2K2;MAP2K1 PTPN11 JAK1 MAPK3 JAK2 IL6R ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 97%167242 Abortive elongation of HIV-1 transcript in the absence of Tat NCBP1 POLR2I SUPT4H1-1 SUPT5H POLR2J;POLR2J2;POLR2J3 NCBP2-1 POLR2E POLR2F CTDP1 GTF2F1 POLR2H GTF2F2 POLR2L POLR2A NELFB POLR2B POLR2C NELFCD NELFA POLR2D NELFE POLR2G EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 97%171007 p38MAPK events RALA-1 MAPKAPK2 MAPK14 HRAS MAPK11 MAPKAPK3 MAPK12 RALGDS RALB MAPK13 NRAS PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere BLM RPA1 RPA2 ACD TINF2 POLD3 TERF2 POLD4 DNA2 RPA3 POLD2 POT1 TERF2IP LIG1 TERF1-1 FEN1 POLD1 PCNA WRN DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%3359454 Defective TCN2 causes TCN2 deficiency TCN2 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%9913635 Strand-asynchronous mitochondrial DNA replication MGME1 RNASEH1-1 POLRMT POLG2 EXOG POLG TWNK TOP3A SSBP1 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation AP2A2 NR1H3 AP2S1 MYLIP RPS27A UBB;UBC VLDLR NR1H2 PCSK9 CLTC CLTA AP2A1 UBA52 AP2B1 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis ABL1 ARPC4 ARPC5 WAS ARPC2 ARPC3 YES1 ACTB-1 NCKAP1L MYO9B NCK1 MYH9 ACTR2 ARPC1B ARPC1A WASL ACTG1 CD3G CDC42 SYK FGR HCK FCGR3A;FCGR3B FYN WASF2 WASF3 BAIAP2 NCKIPSD RAC1 MYO10 BTK MYO5A MYO1C ABI2 ELMO1 ABI1 ELMO2 CRK DOCK1 LYN PTK2 ACTR3-1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 VAV1 VAV2 MAPK1 MAPK3 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs ALOX15 ALOX12 HPGD LTA4H PTGS2-2 GSTM4 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 EPHX2 LTC4S ALOX5 CYP1A1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717316 alectinib-resistant ALK mutants ALK CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 97%1834949 Cytosolic sensors of pathogen-associated DNA POLR3GL POLR3A POLR3B TBK1 POLR3C TRIM56 POLR3D PRKDC POLR3E POLR3F POLR3G POLR3H DHX36 POLR3K TRIM32 CREBBP ZBP1 DTX4 RIPK3 STAT6 LRRFIP1 NFKB2 IRF3 AIM2 POLR1C IRF7 POLR1D MYD88 NFKBIB NKIRAS1 TLR3 NKIRAS2 CGAS CTNNB1 CHUK TICAM1 POLR2E DHX9 RIPK1 POLR2F POLR2H IKBKB POLR2L DDX41 IKBKG UBA52 NFKBIA XRCC6 RELA XRCC5 TRIM21 STING1 EP300 RPS27A UBB;UBC NFKB1 IFI16 NLRP4 MRE11 TREX1 CRCP PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%500657 Presynaptic function of Kainate receptors GNB3 GNGT1 GNB5 GNG10 GRIK3 GNG2 GNG5 GNG4 PLCB3 GNG8 PLCB1 PLCB2 GNG13 GNB2 GNB1 GNB4 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.5 Activation of BH3-only proteins BCL2L11 BAD TP73 BCL2 PMAIP1 YWHAG AKT2 BMF AKT3 BID BBC3 PPP3CC YWHAB AKT1 SFN TP63 YWHAZ PPP1R13B PPP3R1 YWHAQ YWHAH TP53 TFDP1 TFDP2 TP53BP2 YWHAE MAPK8 E2F1 NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 97%9032759 NTRK2 activates RAC1 BDNF RAC1 DOCK3 NTRK2 SCN4%REACTOME DATABASE ID RELEASE 97%3282872 SCN4 G6PC3 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 97%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A TRANSLATION%REACTOME DATABASE ID RELEASE 97%72766 Translation RPS14 RPS17 RPS16 MARS1 RPS19 RPS18 N6AMT1 RPS11 GSPT2 GSPT1 RPL10A RPS10 RPS13 RPS12 RARS1 ETF1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4EBP1 EIF4H RPL27A EIF3M EIF3K EIF3L PSMD12 EIF3I EIF3J PSMD11 EIF3G PSMD14 EIF3H LARS1 MRPS17 PSMD13 EIF3E C12orf65 GFM1 EIF3F MRPS15 MIEF1 EIF3D MRPS16 MALSU1 EIF3A MRPS14 PSMA7 MTFMT EIF3B MRPS11 MTIF2 PSMD8 MRPS12 MTIF3 MRPL38 MTRES1 MRPL39 PSMB6 MRPS10 PSMB7 PSMD6 RPS25 MRPL36 RPS27 MRPL37 PSMB4 PSMD7 RPS29 MRPL34 MRPL35 PSMB5 SRP14 RPS20 MRPL32 PSMB2 RPS21 MRPL41 PSMB3 PSMD2 AARS1 RPS24 MRPL4 PSMD3 HARS1 RPS23 MRPL42 PSMB1 YARS1 MRPL3 PSMD1 RPL36AL-1 MRPL2 WARS1 MRPL40 GARS1 NARS1 MRPL1 FARSA MRPL9 ADRM1 CHCHD1 CARS1 TARS1 MRPS28 PSMC2-1 FARSB TSFM MRPS26 PSMA2-1 VARS1 MRPS27 PSMA5 MRPS24 SEM1 MRPS25 PSMA6 MRPS22 PSMC5 MRPS23 PSMA3 MRPL49 PSMC6 MRPS18B PSMA4 MRPS21 MRPS2 PSMC3 MRPS18A PSMA1 MRPL47 PSMC4 MRPL48 PSMC1 EEF1B2-1 MRPS7 EEF1G MRPL46 EEF1A1 MRPS6 EEF1D MRPL43 EEF1A2 MRPS5 EEF2 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 RPS27L MRPS9 MRPL51 RPS15A AURKAIP1 DAP3 MRPL18 RPS3 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 UBA52 MRPS35-1 MRPL17 RPS2 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 RPL18A MRPL20 FAU PTCD3 RPL12-1 VCP-1 GADD45GIP1 MRPL27 RPS27A MRPL28 ERAL1 MRPL24 MRPL21 UBB;UBC MRPL22 MRPL30 RPS9 LOC107987373;MRPL23 RPS7 PABPC1;PABPC3 RPS8 RPS5 DARS1 RPS6 EIF4G1 RPSA TUFM RBX1 RPL26L1 RPL4 APEH RPL30 RPL3 RPL32 RPL31 RPL34 ZNF598 ASCC2 RPL8 ASCC3 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 EIF4A2 EIF4A1 RPL24 RPL27 RPL26 RPL29 RPL28 RPL15-1 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF4E EIF4B EIF2S3;EIF2S3B EIF2B1 EIF2S1 RPL3L RPLP1-2 ABCE1 PPA2 RARS2 AARS2 PARS2 MARS2 DARS2 HARS2 YARS2 ELOC-1 FARS2 RPL11 WARS2 LARS2 RPL14 SARS2 SRPRB-1 ELOB RPL13 NARS2 TARS2 RPL18 RPL17 IARS2 RPL19 VARS2 CARS2 EARS2 AIMP1 AIMP2 EPRS1 SEC11A SEC11C SSR1 EEF1E1 MRPS36 RPL10;RPL10L-1 SPCS3 SPCS2 SPCS1 RPL7A NDUFAB1 UBE2D3-1 SARS1 RPLP0 SRPRA TRMT112 RPLP2 SRP19 TRAM1 RPL36-1 RPL35A SRP54 SSR4 SSR2 SSR3 SRP9 SRP72 SRP68 ANKZF1 KLHDC10 NPLOC4 KARS1 TCF25 UFD1 NEMF RPL22L1 EIF5 RPL37A-1 EIF5B QARS1 LTN1 SEC61A2 SEC61A1 SEC61G SEC61B PPA1-1 CUL2 RPL13A-1 RPL5-1 OXA1L UBE2D3;UBE2D2 IARS1 UBE2D1 RPL23A GFM2 MTRF1 MTRF1L MRRF RCHY1 RPS15 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 97%9818026 NFE2L2 regulating inflammation associated genes MAFK NFE2L2 CREBBP EP300 CCL13;CCL2 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702614.2 ponatinib-resistant FLT3 mutants FLT3 ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 97%6802957 Oncogenic MAPK signaling BCL2L11 MARK3 TRAK1 FXR1-1 FAM114A2 PPP1CC MAP3K11 DUSP6 DUSP7 KDM7A JAK2 AGK CLCN6 VCL TLN1 ZC3HAV1 SRC FN1 DUSP8 IQGAP1 SPRED3 DUSP9 LMNA ARRB2 SPRED2 SPRED1 FAM131B CSK HRAS CAMK2B AKAP9-1 CAMK2D BRAP PPP1CB CAMK2A KIAA1549 RAP1B NRAS ESRP1 NF1 CAMK2G MRAS TRIM24 ARAF KRAS CALM3;CALM1 MPRIP AGTRAP RAF1 CNKSR2 YWHAB ITGB3 SND1 CNKSR1 AGGF1 PEBP1 DUSP16 DUSP10 FGB FGA ARRB1 FGG ITGA2B TENT4A VWF AP3B1 MAP2K2;MAP2K1 QKI PAPSS1 RAP1A MAPK1 ATG7 BRAF KSR1 PHB MAPK3 KSR2 SHOC2 APBB1IP SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses NUP133 TLR2 TBK1 NUP50 POM121;POM121C NUP54 B2M ATG14 NUP42 SAR1B CREBBP PIK3R4 NUP43 RAE1 RANBP2 NUP35 IKBKE JAK1 TOMM70 NUP37 RIPK2 SFTPD TYK2 IL17RC IL17RA CHUK HSP90AA1 SIKE1 DDX58 TLR8 ISG15 TLR7 IFIH1 RNF135 IKBKB TRIM25 IKBKG NUP214 STAT1 STAT2 SEC24D-1 NLRP12 STING1 IL17F IL17A KPNA2 MAP3K7 MASP1 UBE2V1 IFNAR1 TKFC IRAK1 IRAK2 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E MAVS UBE2N TAB3 TAB2 TAB1 HSP90AB1 LARP1-1 IRF3 TRAF3 MBL2-1 TRAF6 IRF7 PIK3C3 BECN1 SEC23A NOD1 NOD2 CNBP-1 SEC24B IFNB1-4 SEC24A PTPN11 PTPN6 NUP107 NUP188 SEC24C NUP210 NUP93 NUP205 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 NUP62 TLR1 NDC1 SEC13 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate DOLK MVD SRD5A3 DHRSX NUS1 DOLPP1 DHDDS DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME DATABASE ID RELEASE 97%5619088 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 FGF20 FGF23 FGFR3 FGF1 FGF4 FGF16 FGF9 FGF2 FGF18 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes ME1 NFE2L2 IDH1 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 97%1502540 Signaling by Activin INHA SMAD2;SMAD3 FST FOXH1 SMAD4 TGFBR3 MAPK1 MAPK3 ACVR1B INHBB INHBA FSTL3 ACVR1C ACVR2B DRAP1 ACVR2A LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304347 Loss of Function of SMAD4 in Cancer SMAD2;SMAD3 SMAD4 BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%173107 Binding and entry of HIV virion CD4 CXCR4 CCR5 PPIA YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression HIPK1 TEAD1 TEAD2 KAT2B TEAD3 HIPK2 YAP1-1 TEAD4 WWTR1 TBX5 GATA4 NKX2-5 NPPA CCN2 INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-9020558.5 Interleukin-2 signaling SYK LCK SHC1-1 PTK2B STAT5A IL2RA IL2 STAT5B IL2RB IL2RG JAK1 JAK3 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 97%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis ADSS1 PPAT ADSL IMPDH1 ADSS2 ATIC IMPDH2 PAICS GMPS PFAS GART DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME DATABASE ID RELEASE 97%5678771 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport RHCG RHBG RHAG SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3311021.3 SMAD4 MH2 Domain Mutants in Cancer SMAD2;SMAD3 SMAD4 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI CYP24A1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells NR5A1 SMAD2;SMAD3 DPPA4 STAT3 EPHA1 PBX1 PRDM14 FGF2 LIN28A SMAD4 ZIC3 ZSCAN10 TDGF1 SALL4 SALL1 KLF4 POU5F1;POU5F1B SOX2 FOXD3 NANOG;NANOGP8 EPAS1 HIF3A SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 97%9753510 Signaling by RAS GAP mutants KRAS HRAS NRAS DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 97%420597 Nectin Necl trans heterodimerization PVR NECTIN4 NECTIN3 NECTIN1 CADM3 CADM1 NECTIN2 ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 97%3000178 ECM proteoglycans ITGB1 ITGB5 FMOD ITGA2 LUM ITGAV ITGB6 HSPG2 BCAN DAG1 ITGA8 SERPINE1 LAMA1 COL9A1 SPARC COL9A3 DMP1 COL9A2 MUSK LAMC1 NCAN NCAM1 PTPRS BGN MATN1 MATN4 VCAN MATN3 TNXB DSPP TNC COMP IBSP TGFB1 TNN TNR VTN DCN ITGB3 HAPLN1 ITGAX LAMA5 ITGA2B LAMA3 ASPN ITGA7 ACAN LAMA2 LAMA4 LRP4 LAMB2 AGRN LAMB1 ITGA9 TGFB2 TGFB3 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 97%5619052 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 97%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.5 Cargo recognition for clathrin-mediated endocytosis IGF2R NECAP1 TGFA COPS4 APOB COPS2 AVPR2 CD4 CHRM2 WNT5A ADRB2 GRK2 FZD4 M6PR CLTB SCARB2 ARRB2 AGFG1 EGF STON1-GTF2A1L KIAA0319 TOR1A EGFR TOR1B SYT9 SYT8 DAB2 IL7R CLTCL1 SNAP91 STON2 EPS15L1 SLC2A8 EPN1 SLC18A3 SGIP1 EPN2 VAMP4 FCHO1 FCHO2 UBQLN1 REPS2 AREG REPS1 UBQLN2 EPS15 NECAP2 SYT11 CFTR EREG BTC STAM HBEGF PICALM CLTC CLTA UBA52 AP2A1 AP2B1 CBL AP2A2 SYT1 VAMP2 AP2S1 SH3GL2 ITSN2 RPS27A TFRC UBB;UBC ITSN1 TF SH3GL3 SH3GL1 CD3D GRK3 CD3G VAMP3 GPS1 AGTR1 STAM2 HGS LRP2 TACR1 EPGN ARRB1 SYT2 LDLRAP1 COPS7B COPS7A VAMP7 VAMP8 SH3KBP1 TGOLN2 COPS3 COPS6 COPS5 AVP LDLR COPS8 DVL2 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 97%2465910 MASTL Facilitates Mitotic Progression PPP2R1B CDK1 PPP2R1A ARPP19 CCNB1 PPP2CB;PPP2CA ENSA MASTL PPP2R2A;PPP2R2D MITOCHONDRIAL RNA DEGRADATION%REACTOME DATABASE ID RELEASE 97%9836573 Mitochondrial RNA degradation FASTKD5 TBRG4 GRSF1 SUPV3L1 PNPT1 SLIRP REXO2 LRPPRC FASTKD2 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%391908 Prostanoid ligand receptors PTGER1 TBXA2R PTGDR PTGIR PTGER4 PTGER2 PTGER3 PTGFR PTGDR2 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function LRAT RBP1 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%193993 Mineralocorticoid biosynthesis HSD3B1;HSD3B2 LHB CYP21A2 CYP11B1;CYP11B2 CGA INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria EPCAM UPK1A GBP2;GBP3;GBP1 HBD;HBB RPS27A GBP7;GBP4 CALM3;CALM1 UBB;UBC HBA2;HBA1 GBP6 UBE2D3;UBE2D2 CASP5;CASP4 UBA52 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9730414 MITF-M-regulated melanocyte development DPF1 DPF2 AIMP1 MARS1 DPF3 MARK3 AIMP2 AKT2 SMARCC1 AKT3 SMARCC2 EPRS1 RARS1 PPARGC1A CREBBP RAB27A IRF4 SS18L1 POMC SMARCA2 LARS1 CDC25B SMARCA4 LEF1 EEF1E1 SERPINE1 YWHAE SS18 ACTL6A PXDN MET ATP6V1E1 CDKN1A SIRT1 ATP6V1G1 YWHAG CTNNB1 BRCA1 TYRP1 TCF7 MYO5A CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 GXYLT2 TERT SYTL2 PMEL EDIL3 MLANA TBX2 MLPH TCF7L1 ATP6V0D1 WNT3A YWHAB MC4R ATP6V1A HINT1 EDNRB PAX3 SOX2 TNFSF11 FOXD3 XPO1 ZIC1 EDN1 KIT EDN3 TFE3 MITF PXN SOX10 POU3F2 MC3R TFEC ALX3 YWHAZ TBX3 CSF1 ATP6V1C1 MC1R CCNB1 KARS1 MC5R CDK2 ID1 EP300 RPS6KA1 MAPK14 DARS1 PLK1 ZEB1 ATP6V0B ATP6V1B2 ATP6V0C BCL2 SNAI2 GMPR ITGA2 TYR ACTB-1 GSK3B CDH1 SOX9 UBE2I BCL7A STT3B QARS1 SIN3A BCL7C BCL7B ATP6V0E2;ATP6V0E1 MYRIP SUMO1 YWHAH BCL2A1 ARID1A TRPM1 ARID1B SMARCD1 SMARCD2 SMARCD3 HDAC1 DICER1 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 USF1 TFEB AGO3;AGO1 TNRC6B CCND1 LIG1 ATP6V1H SMARCE1 TFAP2A DIAPH1 IARS1 BIRC7 GPR143 TCF7L2 MCM5 CDKN2A MCM2 CDH2 ASAH1 MAPK1 MAPK3 SMARCB1 DCT TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP10 FADD CFLAR CASP8 TNFSF10 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells EGF FGF10 FGF4 FGF2 FGF7 SIGNALING BY LRP5 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339717 Signaling by LRP5 mutants KREMEN1 KREMEN2 DKK1 DKK2 DKK4 LRP5 POTENTIAL THERAPEUTICS FOR SARS%REACTOME DATABASE ID RELEASE 97%9679191 Potential therapeutics for SARS SOS1 BRMS1 TBK1 ITGB1 IFNGR1 RBX1 SUDS3 IFNGR2 IFNAR1 ATP1A4 RCOR1 ATP1A3 ATP1A2 ATP1A1 S1PR1 PTGES3-1 HMG20B ACE2 CHD4 CHD3 NCK1 ATP1B3-1 JAK2 FXYD2;FXYD6-FXYD2 ZBP1 NR3C1 IL1R1 HSP90AB1 REST CD79B ROCK2 CD79A FKBP1A CYSLTR1 SYK CRBN FNTA JAK1 ROCK1 CUL3 FKBP4 HDAC2 JAK3 HDAC1 TYK2 COMT MTA1 PDCD1 FNTB;CHURC1-FNTB NFE2L2 RBBP4 BRD4 SAP30L PLCG2 BLNK ATP1B2 TLR9 HSP90AA1 BTK ATP1B1 SAP18 RIPK1 TLR7 RBBP7 MTA2 MTA3 IMPDH1 IMPDH2 MBD3 IL6R AP2A1 AP2B1 KEAP1 AP2A2 KDM1A STAT2 ITGA4 GATAD2B FURIN AP2S1 GATAD2A ARID4B SH3KBP1 FXYD4 FXYD3 ARID4A SAP30 FXYD1 VAV1 FXYD6 PHF21A SIGMAR1 TUBB4A;TUBB;TUBB8B;TUBB8 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 97%428540 Activation of RAC1 SOS1 BUB1B-PAK6;PAK6 SOS2 PAK1 RAC1 PAK3 PAK5 ROBO1 PAK4 NCK2 SLIT2 NCK1 PAK2 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9937850 NuRD complex assembly FBP1 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I CHD3 G6PC1 H2BC21 PWWP2B CHD5 IKZF1 IKZF2 SUMO1 IKZF3 H2AC20 PHF6 MBD3L1 H2AB2;H2AB3;H2AB1 ZMYND8-1 PWWP2A H2AZ2;H2AZ1 ZNF687 TCF19 ZNF592 ZNF827 NR2F2 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 CDK2AP2 CDK2AP1 ZNF532 HDAC2 NR2C2 HDAC1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 MBD2 H2BC1 GATAD2B GATAD2A H2AC4 PCK1 H2AC14 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME%R-HSA-9665230.4 Drug resistance in ERBB2 KD mutants CDC37 ERBB2 ERBIN HSP90AA1 EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%72613 Eukaryotic Translation Initiation RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4EBP1 EIF4H RPL27A EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RPL22L1 EIF5 RPL37A-1 RPL26L1 RPL4 RPL30 EIF5B RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 EIF4A2 EIF4A1 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF4E EIF4B EIF2S3;EIF2S3B EIF2B1 EIF2S1 RPL3L RPL5-1 RPLP1-2 RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 97%5657560 Hereditary fructose intolerance ALDOB NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME DATABASE ID RELEASE 97%9818028 NFE2L2 regulates pentose phosphate pathway genes G6PD NFE2L2 MAFG TALDO1 PGD CREBBP EP300 TKT TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 97%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ERBB2 YY1 TGFA EGFR VEGFA ATAD2 TFAP2A CGA TFAP2C KIT ESR1 TFAP2E;TFAP2B BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification ATP6V1H MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 NCL-1 RPS13 RPS12 NOP56 RPL27A RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 PELP1 RPLP2 RPL36-1 RPL35A RPS27L CSNK1D RPS15A LTV1 RRP1 FTSJ3 RPS3 EBNA1BP2 ISG20L2 ERI1 LAS1L NOL12 UBA52 RBM28 RIOK2 RPS2 RIOK1 DIS3 TEX10 SENP3 GNL3 NIP7 NOL9 PES1 RIOK3 WDR18 EXOSC7 WDR12 EXOSC6 BYSL RPL18A EXOSC5 BOP1 FAU EXOSC4 TSR1 RPL12-1 MTREX EXOSC9 RPS27A EXOSC8 EXOSC3 EXOSC2 EXOSC1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TPTEP2-CSNK1E;CSNK1E RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X SNU13 EXOSC10 RPL35 RPL38 RPS3A C1D RPP30 MPHOSPH6 RPL39 DDX49 DDX47 RPP38 WDR3 FCF1 RPP21 RPP25 RPL21 WDR46 RPL23 WDR43 RPP14 RRP9 FBL RPL22 LOC102724159;PWP2 RPP40 BUD23 UTP14C;UTP14A UTP15 WDR36 UTP11 RPL24 IMP3 RPL13A-1 WDR75 RPL27 IMP4 RPL26 DDX52 RPL29 UTP18 RPL28 DDX21 UTP25 HEATR1 RPL15-1 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 RPL3L RPL5-1 DCAF13 NOP58 NOP14 UTP6 UTP4 KRR1 PNO1 UTP3 RCL1 TBL3 MPHOSPH10 RPLP1-2 NOL11 RPL23A RPL11 RPL14 XRN2 RPL13 RPL18 RPL17 RPL19 RPS15 NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%373752 Netrin-1 signaling PTPN11 RAC1 MYO10 EZR UNC5A DCC ROBO1 UNC5B UNC5C PITPNA UNC5D PRKCQ NTN1 SLIT1 SLIT2 RGMB NCK1 RGMA DOCK1 PTK2 DSCAM SLIT3 WASL AGAP2 SRC HJV DSCAML1 TRIO CDC42 NTN4 ABLIM1 PLCG1 TRPC7 ABLIM2 NEO1 TRPC5 ABLIM3 TRPC6 TRPC3 SIAH2 TRPC4 SIAH1 TRPC1 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 97%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 97%8877627 Vitamin E transport TTPA MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702600.2 midostaurin-resistant FLT3 mutants FLT3 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding PFDN6 TUBAL3 GBA GNA14 AP3M1 GNG10 STAT3 GNA15 GNG2 GNG5 GNG4 CSNK2A1;CSNK2A3 GNA11 GNG8 CCT8 TUBA3E;TUBA3C-1 CCT7 ACTB-1 CCT5 CCT4 NOP56 ARFGEF2 GNG13 CCT6A GNAQ GNB2 GNB1 PDCL GNB4 GNB3 SKIV2L FBXL3 GNB5 RGS11 FBXL5 TUBA8 WRAP53 TP53 HDAC3 TUBA1A CSNK2A2 CSNK2B TUBA4A DCAF7 CCT6B PFDN4-1 GNGT1 TUBA1C KIF13A TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 CCT3 FBXW4 CCT2 FBXW10;CDRT1 FBXW5 TUBB2B;TUBB2A VBP1 FBXW7 SPHK1 FBXW9 FBXW2 CCNE2 CCNE1 TCP1 XRN2 GAPDHS PFDN1 TUBB4B PFDN2 FKBP9 TUBB4A;TUBB;TUBB8B;TUBB8 PFDN5 TUBB3;TUBB6 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380259 Loss of Nlp from mitotic centrosomes CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 97%8941413 Events associated with phagocytolytic activity of PMN cells MPO LPO FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate WNT3A SOX1 ZEB2 OTX2 SOX2 POU3F1 ZNF521 TBX6 FGF8 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER ISY1;ISY1-RAB43 RBX1 CDK7 MNAT1 POLR2A POLR2B POLD1 POLR2C POLR2D POLR2G ZNF830 POLR2I RFC5 TCEA1 RFC3 RFC4 RFC2 GTF2H2C;GTF2H2C_2;GTF2H2 UVSSA ERCC8 POLR2E XAB2 LIG1 POLR2F POLR2H POLK POLE POLR2L RFC1 LIG3 ERCC3 PCNA UBA52 PPIE ERCC2 DDB1 GTF2H1 GTF2H3 ERCC6 GTF2H4 RPA1 RPA2 AQR POLD3 POLR2J;POLR2J2;POLR2J3 POLD4 PRPF19 POLD2 RPA3 RPS27A XRCC1 POLE4 CUL4A UBB;UBC POLE2 POLE3 CCNH CUL4B USP7 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373760 L1CAM interactions SCN1A SPTBN2 ITGB1 ANK2 SHTN1 KCNQ2 KCNQ3 CNTN6 CHL1 ITGA2 CSNK2A1;CSNK2A3 SPTBN4 PAK1 ITGA10 ITGAV ANK1 SPTBN5 NUMB SCN3B SCN3A CD24 SCN2A SCN2B NRP2 SCN9A SDCBP NRCAM SCN8A CNTN1 SPTA1 SCN5A GAP43 DCX SCN4A SCN4B LAMA1 DLG1 ANK3 SCN7A NRP1 EGFR LAMC1 NCAN NCAM1 CNTN2 CSNK2A2 RANBP9 RAC1 EZR CSNK2B RPS6KA6 ITGB3 SPTBN1 CLTC CLTA AP2A1 DPYSL2 AP2B1 RDX AP2A2 DLG3 DLG4 DNM1 ITGA1 DNM2 MSN ITGA2B DNM3 AP2S1 ALCAM SCN11A SH3GL2 SCN10A ITGA5 SPTAN1 L1CAM KIF4B;KIF4A LYPLA2 LAMB1 RPS6KA3 CNTNAP1 RPS6KA5 RPS6KA2 SPTB RPS6KA1 ITGA9 MAP2K2;MAP2K1 HSPA8 VAV2 MAPK1 MAPK3 NFASC RPS6KA4 EPHB2 SCN1B DRUG ADME%REACTOME DATABASE ID RELEASE 97%9748784 Drug ADME ADAL ABCC5 PNP-1 GMPS ADH1C;ADH1B;ADH1A GSTT1 TPMT PON3 SULT2A1-4 PON1 GSTA3;GSTA5;GSTA1;GSTA2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 BSG NT5C2 BCHE GUK1 NME2 SLCO1A2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 NME1 SLC28A2 ABCB1 SLC29A1 ALB UGT2A1 SLC29A3 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SLC29A2 SLC28A3 HSD11B1 HSD11B2 XDH UGT1A1;UGT1A6 HPRT1 GLYATL3 CNDP2 SLC22A2 ACSM2A;ACSM2B RAC1 SLC22A1 GGT1 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 IMPDH1 IMPDH2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCG2 CYP2E1 ADA ITPA ADK SERPINA6 GSTA3;GSTA1 ACSM5 GGT5 ACSM4 GGT7 GGT6 GSTP1 SLC16A1 ABCC4 VAV3 GLYAT SLC22A3 CES2 SLC22A8 CES1 VAV1 VAV2 PCK1 NAT1 GSTM1;GSTM2-1 ACY1;ABHD14A-ACY1 NUDT15 ABCC3 ABCC1 ABCC2 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores NUP133 DYNC1LI1 DYNC1LI2 KIF18A BUB1 NDC80 RANGAP1 CLASP2 CENPN-2 MIS12-1 BUB1B CDCA8 CDC20 SKA1 PPP1CC SKA2 BUB3 MAD2L1 DYNC1I1 SPDL1 NUP43 B9D2 SPC24 SPC25 RANBP2 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP NSL1 RPS27 KNTC1 CENPA BIRC5 CENPE CENPC SGO1 NUP37 SGO2 AURKB CENPS-CORT;CORT;CENPS MAPRE1-1 PPP2R1A CENPT NUP107 CENPU KNL1 ZW10 CENPF CENPH CENPI TAOK1 DSN1 CENPK CENPL CKAP5 CENPM RCC2 ZWINT XPO1 CENPO NUP160 CENPP AHCTF1 PAFAH1B1 NUP85 CENPQ DYNC1I2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E CLIP1 MAD1L1 DYNC1H1 NDE1 ITGB3BP PLK1 SEC13 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding PFDN6 TUBAL3 TUBA1A CCT8 TUBA3E;TUBA3C-1 CCT7 ACTB-1 CCT5 CCT4 CCT6A TUBA4A CCT6B PFDN4-1 TUBA1C TUBB1 TUBA8 CCT3 CCT2 TUBB2B;TUBB2A VBP1 TCP1 TUBB4B PFDN1 PFDN2 TUBB4A;TUBB;TUBB8B;TUBB8 PFDN5 TUBB3;TUBB6 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression TAF1D SIRT1 TAF1B H2AC20 TBP TAF1C H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SUV39H1 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 RRP8 H2BC1 H2AC14 H2BC21 SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%1643713 Signaling by EGFR in Cancer CBL GAB1 SOS1 PIK3CA AREG TGFA HSP90AA1 RPS27A EREG BTC UBB;UBC EGF CDC37 SHC1-1 PLCG1 EGFR HRAS PIK3R1 HBEGF EPGN NRAS UBA52 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants ALK SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants SOS1 STAT1 PIK3CA LCK STAT5A STAT3 PIK3R3 STAT5B YES1 PIK3R2 HRAS PIK3R1 FYN JAK2 LYN KIT NRAS CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.6 Cell Cycle, Mitotic ESCO1 BUB1 FBXL18 ESCO2 CLASP2 AKT2 AKT3 CSNK2A1;CSNK2A3 PPP1CC GOLGA2 CDC25A HMMR CDC25B PRIM2 PRIM1 POLA1 POLA2 RPS27 LPIN1 LPIN2 LPIN3 SKP2 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 PPP1CB MAPRE1-1 PRKACA-1 ACTR1A TUBA1A LBR PPP2R1A CNTRL CEP250 NEK2 BTRC CEP290 YWHAG RAB8A SKP1 CDK5RAP2 HSP90AA1 OPTN-1 HJURP CEP135 PPP1R12A MIS18BP1 BORA FBXW11 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 AJUBA UBA52 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 KIF20A CEP192 RPS27A PCNT CEP76 OBI1 LCMT1 CLASP1 UBB;UBC PPME1 CEP78 TICRR PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 KIF18A IST1 SPAST CC2D1B DHFR2;DHFR JAK2 KIF23 HSP90AB1 TYMS KIF2A KIF2C KIF2B CABLES1 CENPE WEE1 MAX LMNB1 PPP2R2A;PPP2R2D TUBA1C TUBB1 E2F5 E2F6 TUBB2B;TUBB2A CCNE2 CCNE1 RB1 CCNH H2AC14 TUBB3;TUBB6 TUBAL3 TUBA3E;TUBA3C-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CCND3 CCND2 CDKN2D CDKN2C TUBA8 H2AC20 H2AB2;H2AB3;H2AB1 MYBL2 DNA2 E2F4-1 TFDP1 TFDP2 RAB1A RAB1B E2F1 CDC7 E2F3 TPX2 CDKN1A CDKN1B H2AJ CDCA5 PDS5B PDS5A WAPL ESPL1 CDKN2B H2BC5 PCNA H2BC1 RPA1 PTK6 RPA2 CDK4 CDK2 PTTG1;PTTG2 RPA3 EP300 PHLDA1 H2AC4 KMT5A CDK11A;CDK11B CDC25C CDK6 ABL1 CDK7 MNAT1 GSK3B KPNB1 H2BC21 H2AZ2;H2AZ1 RFC5 RFC3 RFC4 RFC2 RBL2 RBL1 BIRC5 SMC3 AURKB RAD21 STAG1 HDAC1 STAG2 SMC1A RBBP4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLE RFC1 LIN54 LIN37 H2BC15;H2BC3;H2BC11;H2BC12 LIN9 LIN52 LYN GINS1 GINS2 CDC45 MCM7 MCM8 GINS3 POLD3 GINS4 MCM3 POLD4 MCM4 POLD2 MCM5 MCM6 MCM2 POLE4 MAPK1 POLE2 POLE3 BUB1B CDC20 FBXO5 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 C1orf112 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 LEMD3 XPO1 AKT1 TNPO1 NUP214 PRKCA ANKLE2 SET-1 MCM10 DBF4 PRKCB DYNC1LI1 DYNC1LI2 RBX1 CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 GTSE1 FKBPL NUF2 EMD NUDC INCENP CENPA CENPC E2F2 CENPT TOP2A NUP107 CENPU NUP188 RCC1 BANF1 NUP210 CENPF CENPH LIG1 GORASP1 CENPI NUP93 TAOK1 CHMP4C CENPK CHMP4B CHMP4A CENPL NUP205 USO1 CENPM NEK9 NEK6 AAAS NEK7 CENPO CENPP NUP160 NUP85 CENPQ TPR NUP88 NUP155 NUP153 CHMP2B CHMP2A RRM2-1 CLIP1 FEN1 MAD1L1 NUP62 CDKN1C NDC1 SEC13 NUP133 NDC80 RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 NUMA1 CHMP7 TUBG2 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 VPS4A TUBGCP4 SPDL1 NUP42 NUP43 RAE1 RANBP2 NSL1 NUP35 RAN NUP37 GMNN ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KNL1 ZW10 DSN1 EML4 RCC2 ZWINT CDC14A AHCTF1 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E FOXM1 VRK1 LEMD2 CTDNEP1 CNEP1R1 FBXL7 RAB2A GORASP2 BLZF1 SMC4 DYNC1I1 SMC2 NCAPG NCAPH NCAPD2 UBE2I DYRK1A POLD1 CKS1B PPP2R3B B9D2 SPC24 SPC25 PKMYT1 ERCC6L ARPP19 NCAPH2 SUMO1 NCAPG2 ZWILCH NIPBL ENSA SIRT2 NCAPD3 PMF1;PMF1-BGLAP MAU2 MASTL MCPH1 TP53 KNTC1 SGO1 SGO2 MYC CENPS-CORT;CORT;CENPS CSNK2A2 CCND1 CSNK2B ANAPC15 ANAPC16 TK1 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 CDKN2A UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.4 Transport of the SLBP independent Mature mRNA NCBP1 NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 EIF4E NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NXF1 NUP88 RAE1 RANBP2 NUP155 NUP153 ALYREF NCBP2-1 NUP35 NUP62 NUP37 NDC1 SEC13 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema F2 KLKB1 F12 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-HSA-8849468.2 PTK6 Regulates Proteins Involved in RNA Processing PTK6 SFPQ-1 KHDRBS1 KHDRBS2 KHDRBS3 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 97%9006115 Signaling by NTRK2 (TRKB) FRS2 TIAM1 BDNF GAB1 SOS1 PIK3CA CDK5R1 PTPN11 NTF3 SRC RAC1 DOCK3 CDK5 GRIN2B PLCG1 HRAS PIK3R1 FRS3 NRAS NTRK2 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 97%69017 CDK-mediated phosphorylation and removal of Cdc6 CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CDC6 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDK2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 CCNE2 ANAPC4 CCNE1 ANAPC5 ANAPC1 ANAPC2 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 97%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 97%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components LIMS4;LIMS1 PARVA TESK1 ARHGEF6 ACTN1 RSU1 PARVB PXN HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 97%5685942 HDR through Homologous Recombination (HRR) BLM RAD51 POLD1 RAD9B KAT5 POLH CHEK1 RAD51B RAD9A RAD51C HUS1 EXO1 MUS81 C1orf112 EME1-1 BRCA2 TOPBP1 DNA2 RAD51AP1 RHNO1 SLX4 EME2 RFC5 RFC3 FIGNL1 GEN1 RFC4 XRCC2 RFC2 XRCC3 PALB2 SPIDR SLX1A;SLX1B ATRIP BARD1 RBBP8 SEM1 RAD17 ATM RAD50 ATR BRCA1 POLK POLE RMI2 RFC1 RMI1 TOP3A RAD51D PCNA UBA52 WRN RPA1 RPA2 POLD3 POLD4 POLD2 RPA3 RPS27A RAD1 POLE4 UBB;UBC BRIP1 MRE11 POLE2 POLE3 NBN RTEL1 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes LPL MED30 PDK4 ABL1 MED1 ACSL1 CDK8 MGLL MED4 CDK5 MED6 MED7 AGPAT2 PAXIP1 PEX11A CCNC-1 DPY30 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PAGR1 PPARGC1B CREBBP H2BC21 CIDEC WDR5 RXRA KDM6A GPAM H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 LPIN1 ASH2L MED16 PNPLA2 MED17 MED12 MED14 MED13 MED10 CD36 CEBPA NCOA1 NCOA2 ACSS3 NCOA6 ELOVL5 NCOA3 HDAC3 DGAT2 MED27 SIRT1 MED23 NCOR2 RBBP5 H2AJ NR5A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 MED24 MED20 PLIN4 PLIN2 ANGPTL4 PLIN1 GPS2 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 AJUBA SCD H2BC1 THRSP FABP4 MED31-1 EP300 PHLDA1 H2AC4 ADIPOQ TBL1XR1 RB1 KMT2D KMT2C LIPE H2AC14 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling SOS1 PIK3CA PTPN11 PTPN6 PIK3R3 IL3RA IL2RB GAB2 INPPL1 CSF2RB BLNK CSF2RA INPP5D IL5RA YES1 SHC1-1 CRK JAK2 LYN CBL CSF2 YWHAZ STAT5A IL2 STAT5B IL3 PIK3CD SYK PIK3R2 HCK PIK3CB IL5 VAV1 RAPGEF1 IL2RA PIK3R1 IL2RG FYN JAK1 CRKL PRKACA-1 JAK3 TEC SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%180336 SHC1 events in EGFR signaling SOS1 EREG BTC EGF SHC1-1 AREG TGFA HRAS EGFR HBEGF EPGN NRAS LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production LRRFIP1 CTNNB1 CREBBP IRF3 EP300 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013149 RAC1 GTPase cycle ABL2 SRGAP3 SOS1 SRGAP2 GNA13 SRGAP1 PIK3R3 NOXA1 FMNL1 RASGRF2 SNAP23 TAGAP PLEKHG3 PLEKHG4 PLEKHG1 PLEKHG2 PLEKHG6 WASL SOS2 PARD6A IQGAP1 SH3BP1 NHS WASF2 WASF3 ARHGAP5 ARHGAP21 BAIAP2 CDC42BPA DOCK7 LBR BAIAP2L1 OPHN1 TMPO ARHGAP35 LEMD3 SPATA13 RAC1 KTN1 NISCH VANGL1 ARAP1 DEPDC1B GARRE1 KALRN DOCK1 EPHA2 DOCK10 DOCK11 CYFIP2 CYFIP1 GIT1 NCKAP1 VAV3 WASF1-1 TRIO RALBP1-1 TFRC WIPF1 LAMTOR1 WIPF2 WIPF3 ERBIN VAV1 VAV2 TIAM2 PREX2 PREX1 ARHGEF4 RACGAP1 BCR ARHGEF7 ARHGEF5 ITGB1 ARHGEF6 AMIGO2 NGEF WAS NOXO1 DOCK6 IQGAP2 DOCK5 PAK1 IQGAP3 DOCK4 DOCK3 DOCK9 DOCK8 ABR PAK3 PAK5 NCKAP1L PAK4 GIT2 MCAM CAV1 NOX3 MYO9B FERMT2 MPP7 NOX1 DLC1 ARHGAP9 JAG1 ESYT1 ARHGAP1 ARHGAP4 EMD BUB1B-PAK6;PAK6 GMIP ARHGAP39 CIT DOCK2 ARHGAP44 SYDE2 CDC42EP4 CDC42 ARHGAP42 CDC42EP1 ARHGDIA VAMP3 ARHGDIB PIK3R2 CYBB CYBA PIK3R1 ARHGAP45 FGD5 CHN2 ARHGEF25 CHN1 PIK3CA YKT6 ARHGAP17 ARHGAP15 FARP2 FARP1 ARHGAP12 ARHGAP22 ARHGAP20 MCF2 DEF6 ECT2 ARHGEF39 ABI2 ARHGAP29 TAOK3 ARHGAP27 RAB7A ARHGAP26 ARHGAP25 ABI1 ARHGAP24 ARHGAP23 ARHGAP33 PLD1 ARHGAP32 PKN2 ARHGAP31 PKN1 PLD2 ARHGAP30 PAK2 DIAPH3 TIAM1 NCF1 FAM13B NCF2 NCF4 FAM13A MCF2L ARHGEF11 ARHGEF10 SWAP70 ARHGEF15 VRK2 ARAP2 ARHGEF19 ARHGEF18 ARAP3 ARHGAP10 ALS2 SLC1A5 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping JUN WNT5A CYBA NOXO1 MAPK8 DVL1 RAC1 NOX1 NOXA1 FZD7 DVL2 DVL3 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO GRK2 SMO SHH BOC GAS1 ARRB2 CDON EVC2 EFCAB7 EVC GAS8 DHH KIF3A IHH CSNK1A1 PTCH1 ARRB1 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins LOC100509620;LOC112267859;AQP7 AQP9 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%977068 Termination of O-glycan biosynthesis MUC17 ST3GAL4 ST6GALNAC2 MUC5B MUC20 ST3GAL1 ST3GAL2 MUC21 ST3GAL3 MUC12 MUC15 MUC3A MUC5AC ST6GAL1 ST6GALNAC3 ST6GALNAC4 MUC1 MUC2 MUC7 MUC4 MUC6 MUC13 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions SNRPD2 SNRPD1 ELAVL2 SNRPD3 VIM ATG14 SDC4 H2BC18 SDC2 SDC3 PIK3R4 SNRPE-2 SDC1 IKBKE PTBP1 HNRNPH1 HNRNPA1-1 HNRNPM NEK2 CTNNB1 APOA1 HSP90AA1 CDC73 LEO1 GPC1 GPC3 RBMX ELAVL1 GPC2 GPC5 GPC4 GPC6 STAT2 TJP1 STING1 AGRN HSPA8 SNRPF SNRPB DDX5 MAVS HNRNPC HSPG2 HSP90AB1 CPSF2-1 MBL2-1 PIK3C3 NUDT21 BECN1 FUS SNRPG-2 BCAS2 C1S HNRNPA0 HNRNPA3 NFKBIB GPKOW CDC5L DHX9 GTF2F1 GTF2F2 SUGP1 TAOK1 PABPN1-1 MMP9 PEX19 PPIE HNRNPF HNRNPA2B1 POLR2J;POLR2J2;POLR2J3 HNRNPU HNRNPR SNRPA1 WDR61 HNRNPL HNRNPK HNRNPD RPL18 WDR33 H2AC14 ISY1;ISY1-RAB43 PDCD6IP NCBP1 PHF5A AUP1 PAPOLA TXNL4A SNRPN PLRG1 DNAJC8 POLR2A FIP1L1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C SNRNP40 POLR2D PPIL3 PPIL4 PPIL6 SRRM2 POLR2G COG1 POLR2I CRNKL1 DAXX CSTF3 CSTF2 H2AC20 NCBP2-1 HNRNPH2 MAPKAP1 CWC25 PPIL1-1 CWC27 CWC22 PRPF6 PRPF8 CPSF4 CPSF1 SNW1 CPSF3 CWC15 CGAS RBM5 RPTOR TAL1 C4BPA C4BPB IFIH1 LOC110384692;C4A;C4B_2;C4B TRIM25 EXOC1 SF3B1 GRPEL1 H2BC5 GBF1 H2BC1 RICTOR PQBP1 SRRT NRBP1 SNRNP200 H2AC4 FASN CTNNBL1 PRCC CCAR1 U2AF1L5;U2AF1 EIF4A3 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 SYMPK CDC40 RBM10 PAF1 SRRM1 RETREG1 DHX15 DHX16 SRSF2 SRSF3 UBE2I SRSF5 SRSF6 SRSF7 SRSF9 WBP11 HNRNPUL1 H2BC21 SRSF1 U2AF2 PRR5 DDX46 DHX38 DDX42 SRSF11 RBM17 DYNLT1 SRSF4-1 BUD31 ALYREF RBM22 MLST8 RNPS1 DDX23 CSTF2T SMNDC1 U2SURP CLP1 YBX1 CAMK2B CAMK2D CAMK2A UBR4 CAMK2G MTOR SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 LY96 DDX3X-1 SF3A3 SF3A1 SF3A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 XAB2 POLR2E RIPK1 CPSF7 CLEC5A POLR2F POLR2H VTN TLR4 POLR2L CHERP H2BC15;H2BC3;H2BC11;H2BC12 NFKBIA F2 PUF60 SNRPB2 AQR CLU PRPF19 PCF11 H2AC16;H2AC11 EFTUD2 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 97%445989 TAK1-dependent IKK and NF-kappa-B activation S100A12 N4BP1 USP18;USP41 NFKBIB SAA2;SAA1 UBE2V1 NKIRAS1 NKIRAS2 IKBIP TRAF2 CHUK LRRC14 CASP8 USP14 IRAK1 IRAK2 NLRC5 TIFA HMGB1-1 IKBKB IKBKG UBE2N TAB3 TAB2 NFKBIA UBA52 TAB1 APP RELA NFKB2 RPS27A TRAF6 UBB;UBC NFKB1 TP53 MAP3K7 NOD1 NOD2 RIPK2 ALPK1 NLRX1 AGER SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 97%9700206 Signaling by ALK in cancer IL10RA PRF1 GCC2 GZMH;GZMB-1 RBX1 MDM2-2 STAT3 NPM1-2 STRN PRKAR1A MCL1 SEC31A MYH9 SQSTM1 IRF4 VCL RANBP2 STAT5A HIP1 BCL2A1 DCTN1 FN1 PPFIBP1 RRBP1 ALK IRS1 LMO7 TP53 PIK3R2 PIK3CB JUNB PLCG1 PIK3R1 CARS1 FRS2 HDAC1 JUN TYK2 PIK3CA PTPN6 TNRC6C MOV10 CDKN1A ATIC AGO4 AGO2 SKP1 EEF1G AGO3;AGO1 EIF2AK3 GRB2 IL22 EML4 CLTC UBA52 IL10 TPR CEBPB STAT1 MSN CUL1 KIF5B CCNB1 WDCP TPM4 BCL11A TPM3 RNF213-2 RPS27A TFG UBB;UBC ZC3HC1 FOXM1 ZAP70 KLC1 MAPK1 ICOS RB1 MAPK3 RPS6 MAPK9 FRS3 PPM1B DNMT1 MAPK8 BIRC6 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 97%450282 MAPK targets Nuclear events mediated by MAP kinases JUN PPP2R1A MAPK7 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 FOS ATF2 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 RPS6KA1 MEF2A MAPK1 MAPK14 MAPK3 MEF2C MAPK11 MAPK9 MAPK8 MAPK10 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription RUNX3 TEAD1 TEAD2 TEAD3 YAP1-1 TEAD4 WWTR1 CCN2 RHOD GTPASE CYCLE%REACTOME%R-HSA-9013405.5 RHOD GTPase cycle ADD3 DBN1 PGRMC2 SLC4A7 PLXNB1 PAK5 CAPZB EFHD2 MCAM CAV1 ESYT1 ARHGAP1 EMD BUB1B-PAK6;PAK6 ARHGAP39 VAMP3 PIK3R2 PIK3R1 WHAMM LMAN1 ARHGAP5 ARHGAP21 CPNE8 LBR ARHGAP17 TOR1AIP1 ARHGAP12 TMPO ACTN1 ARHGAP35 LEMD3 VANGL1 DEPDC1B RAB7A ARHGAP26 LMNB1 DIAPH1 FILIP1 ARHGAP32 VAPB DIAPH3 AKAP12 HINT2 STBD1 VRK2 RHOD STEAP3 ANKFY1 RACGAP1 MOSPD2 PLXNA1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling WASL SRC RAC1 TRIO CDC42 DCC ABLIM1 NTN1 ABLIM2 ABLIM3 DOCK1 NCK1 PTK2 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste TAS2R7 TAS2R8 TAS2R3-1 GRM4 SCN3A SCN2A TAS2R1 SCN2B TAS2R4 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GRM1 CALHM1 TAS2R16 CALHM3 GNG13 SCN9A GNB1 TAS2R40 GNB3 TAS2R41 ITPR3 PRH1-TAS2R14;TAS2R14-3 TAS1R2 TAS1R1 TAS2R39 TAS1R3 GNAT3 TRPM5 PLCB2 SCN4B TRPM4 SCN1B DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) CP SLC40A1 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 97%9842860 Regulation of endogenous retroelements TRIM28 DPF1 TASOR DPF2 DPF3 ZNF324B;ZNF324 MORC2 SMARCC1 SMARCC2 CBX5 ACTB-1 PIWIL4 ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I CHD3 DNMT3L BCL7A ZNF382 SETDB1 SS18L1 H2BC21 BCL7C ZNF649 BCL7B SMARCA2 SMARCA4 RBM7 H2AC20 SUMO2 ZNF30 H2AB2;H2AB3;H2AB1 DNMT3A H2AZ2;H2AZ1 ARID1A ARID1B ZNF264;ZNF805-1 C19orf84 SMARCD1 SMARCD2 SS18 HDAC2 SMARCD3 ACTL6A HDAC1 PPHLN1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 SMARCE1 ATF7IP MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 ZNF669;ZNF670 GATAD2B GATAD2A MPHOSPH8 ZNF331 MTREX H2AC4 SPOCD1 ZNF317 ZNF354A;ZNF354B-4 SMARCB1 ZCCHC8 EHMT2 EHMT1 H2AC14 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190239.3 FGFR3 ligand binding and activation FGF20 FGF23 FGF1 FGF4 FGF16 FGF9 FGF2 GALNT3 FGF18 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-HSA-73929.5 Base-Excision Repair, AP Site Formation ACD TINF2 TDG H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 MBD4 SMUG1 NEIL2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 NEIL3 NEIL1 H2AC20 NTHL1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 MPG OGG1 H2AC14 SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors RPS14 ABL2 SRGAP3 NCBP1 SOS1 RPS17 SRGAP2 SRGAP1 RPS16 RPS19 CLASP2 MSI1 RPS18 HOXA2 ISL1 COL4A5 RPS11 GSPT2 RPL10A GSPT1 RPS10 LHX3 LHX2 RPS13 LHX4 RPS12 LHX9 USP33 ROBO1 UPF2 ETF1 CAP1 CXCR4 ZSWIM8 NCK2 SLIT1 NCK1 CAP2 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 EVL PFN2-1 PSMA7 SOS2 PSMD8 LDB1 SRC PSMB6 RPL10;RPL10L-1 PSMB7 NCBP2-1 PSMD6 RPS25 RPS27 PSMB4 PSMD7 RPS29 PSMB5 RPS20 PSMB2 RPS21 PSMB3 PSMD2 RPS24 PSMD3 RPS23 PPP3CB NRP1 PSMB1 PSMD1 RPL36AL-1 ADRM1 RPL7A PSMC2-1 PSMA2-1 PSMA5 SEM1 PRKACA-1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 RPLP0 PSMC1 RAC1 PFN1 RPLP2 RPL36-1 RHOA RPL35A RPS27L RPS15A GPC1 RPS3 UBA52 NELL2 SLIT3 RPS2 PRKCA RPL18A FAU RPL12-1 RPS27A CLASP1 UBB;UBC RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA ABL1 FLRT3 RBX1 ROBO2 EIF4A3 CASC3 RPL22L1 PAK1 RPL37A-1 PAK3 RPL26L1 DCC PAK5 PAK4 RPL4 RPL30 NTN1 RPL3 RPL32 SLIT2 MYO9B RPL31 PRKACB-1 RPL34 PRKAR2A RPL8 RBM8A RPL9 RPL6 RPL7 RPS4X MAGOH;MAGOHB RPL35 BUB1B-PAK6;PAK6 RPL38 VASP RPS3A ARHGAP39 UPF3B DAG1 RNPS1 ENAH RPL39 CDC42 RPL21 RPL23 RPL22 RPL24 CUL2 RPL13A-1 RPL27 AKAP5 CXCL12 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 PAK2 RPL23A ELOC-1 RPL11 RPL14 ELOB RPL13 RPL18 RPL17 RPL19 RPS15 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 97%5423599 Diseases of Mismatch Repair (MMR) MSH2 PMS2 MLH1 MSH6 MSH3 PENTOSE PHOSPHATE PATHWAY%REACTOME DATABASE ID RELEASE 97%71336 Pentose phosphate pathway SHPK PRPS2 PRPS1 TALDO1 DERA TKT RPIA G6PD PGM2 PGLS PGD RPE;RPEL1 RBKS TNF SIGNALING%REACTOME DATABASE ID RELEASE 97%75893 TNF signaling TBK1 ULK1 TNF TAB3 TAB2 TAB1 ADAM17 TAX1BP1 IKBKE RNF31 XIAP OTUD7B SPATA2 TNFAIP3 SMPD3 SHARPIN USP21 SMPD2 USP4 RACK1 MIB2 UBE2D3-1 TNFRSF1A TRADD CYLD RBCK1 OTUD1 TRAF2 BIRC2 CHUK BIRC3 CASP8 OPTN-1 RIPK1 FADD BAG4 IKBKB IKBKG UBE2D3;UBE2D2 UBA52 TRAF1 UBE2D1 MAPKAPK2 RPS27A UBB;UBC MAP3K7 SPPL2B SPPL2A CLIP3 STUB1 NSMAF OTULIN USP2 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events NCBP1 EAF1 EAF2 CTR9 RTF1 CDK7 GTF2A1 GTF2A2 CTDP1 PAF1 MNAT1 TAF9 POLR2A SUPT6H POLR2B POLR2C POLR2D AFF4 POLR2G TAF9B POLR2I MLLT1 TAF15 MLLT3 IWS1 TAF12 TBP TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNK CCNT1 GTF2B CDC73 SUPT16H POLR2E LEO1 POLR2F GTF2F1 POLR2H GTF2F2 POLR2L GTF2E1 ERCC3 GTF2E2 ERCC2 GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B ELL ELOC-1 TAF7L WDR61 ELOA NELFB ELOB CCNH NELFCD NELFA NELFE APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.5 APC-Cdc20 mediated degradation of Nek2A NEK2 BUB1B CDC20 BUB3 MAD2L1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 RPS27A ANAPC7 UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 SRGAP3 SRGAP2 SRGAP1 ROBO1 SLIT2 ARHGAP39 RAC1 CDC42 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora EPM2A PPP1R3C UBB;UBC GYG1 GYS1 NHLRC1 RPS27A UBA52 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 97%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription NOTCH1 HES1 SNW1 SMAD2;SMAD3 MAMLD1 RBPJ KAT2B KAT2A MAML2 ACTA2 EP300 MAML1 HES5 FLT4 MAML3 NOTCH2 NOTCH4 HEY1 CREBBP HEY2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000171 Non-integrin membrane-ECM interactions PDGFB ITGB1 ITGB5 ITGA2 ITGAV FGF2 TRAPPC4 SDC4 SDC2 SDC3 HSPG2 DAG1 ITGB4 SDC1 LAMA1 DTNA LAMC2 DTNB LAMC1 SSPN DDR1 THBS1 DDR2 PDGFA DRP2 DMD ACTN1 TNC ITGA6 TGFB1 UTRN VTN TTR ITGB3 CASK LAMC3 SGCE SGCD SGCA SGCB LAMA5 SGCG SNTA1 PRKCA LAMA3 NRXN1;NRXN3;NRXN2 LAMA2 LAMA4 LAMB3 LAMB2 AGRN SGCZ LAMB1 SNTB1 SNTB2 NTN4 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.4 Regulation of actin dynamics for phagocytic cup formation ABL1 ARPC4 ARPC5 WAS ARPC2 LIMK1 ARPC3 PAK1 NF2 ACTB-1 NCKAP1L MYO9B NCK1 MYH9 ACTR2 ARPC1B ARPC1A HSP90AB1 WASL ACTG1 CD3G CDC42 SYK FCGR3A;FCGR3B WASF2 FCGR1A WASF3 BAIAP2 NCKIPSD RAC1 MYO10 HSP90AA1 BTK MYO5A MYO1C ABI2 ELMO1 ABI1 ELMO2 CRK CFL1 DOCK1 PTK2 ACTR3-1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 VAV1 VAV2 MAPK1 MAPK3 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling UBE2V1 INPP5D CD4 TRAT1 UBE2N TAB2 PSMD12 PSMD11 PSMD14 LCK PSMD13 HLA-DPB1-1 HLA-DQB2;HLA-DQB1 CD3E CD3D PSMA7 HLA-DPA1 PDPK1 PSMD8 PTEN HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 PSMB6 PSMB7 CD3G PSMD6 HLA-DRA PSMB4 PSMD7 TRAF6 PSMB5 PSMB2 PSMB3 PSMD2 PIK3R2 PIK3CB PSMD3 PSMB1 PSMD1 PIK3R1 ADRM1 PSMC2-1 RIPK2 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PIK3CA PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 CDC34 IKBKB PRKCQ CARD11 BCL10 IKBKG MALT1 UBE2D3;UBE2D2 UBA52 NFKBIA CUL1 UBE2D1 RELA RPS27A UBB;UBC NFKB1 MAP3K7 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 97%5627117 RHO GTPases Activate ROCKs MYL6 PPP1R12B ROCK2 LIMK2 LIMK1 MYH14 PAK1 MYH11 MYH10 PPP1R12A RHOA RHOC MYL12B RHOB CFL1 ROCK1 MYH9 PPP1CB SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions SDK1 SDK2 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription EGR1 SNAI1 SNAI2 SLC38A9 RCOR1 ATN1 BMI1 SALL4 MAF1 MECOM CHD4 RING1 RHEB CHD3 ATF2 HDAC5 RNF2 HDAC7 REST CBX8 RRAGA RRAGC CBX6 EED RRAGB PHC2 MLST8 PHC1 RRAGD PPARG EZH2 CBX4 CBX2 PHC3 TP53 NR2E1 HDAC2 HDAC3 HDAC1 JUN MTOR MTA1 RBBP4 RPTOR RBBP7 MTA2 MTA3 MBD3 SUZ12 KDM1A GATAD2B GATAD2A LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 MAPK1 MAPK3 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654733 Negative regulation of FGFR4 signaling FGF20 FRS2 PPP2R1A FGF23 PTPN11 FGF2 KLB FGF19 FGFR4 UBA52 CBL PPP2CB;PPP2CA RPS27A UBB;UBC MAPK1 BRAF MAPK3 FGF1 FGF6 MKNK1 FGF4 SPRY2 FGF16 FGF9 FGF18 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors CHRNB2 CHRNA2-1 CHRNA1 CHRNB4 CHRNA3 CHRNB3 CHRND CHRNA5 CHRNA4 CHRNA6 CHRNG CHRNE LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.3 LXR-mediated signaling ABCA1 ABCG5 NR1H3 TNRC6C MOV10 FABP6 APOC1 TNRC6A-1 NRIP1 APOC4 AGO4 AGO2 NCOR2 AGO3;AGO1 TNRC6B NCOR1 ANGPTL3 PLIN1 GPS2 KDM3A NR1H2 KDM4A SCD APOC2 KDM1A RXRA APOD MYLIP EP300 KDM1B CETP ARL4C TBL1XR1 EEPD1 FASN ABCG1 RXRB APOE PCK1 NCOA1 HDAC3 ABCG8 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 97%187687 Signalling to ERKs FRS2 SOS1 KIDINS220 SHC1-1 YWHAB CRK SHC2 RALGDS NTRK1 RALB MAPK13 RIT1 RIT2 NGF RALA-1 MAPKAPK2 SHC3 MAP2K2;MAP2K1 RAP1A RAPGEF1 MAPK1 HRAS MAPK14 BRAF MAPK3 MAPK11 CRKL MAPK12 MAPKAPK3 NRAS EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 97%9036866 Expression and Processing of Neurotrophins NGF PCSK6 FURIN PCSK5 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE GPCPD1 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 97%5685938 HDR through Single Strand Annealing (SSA) RAD17 ATM ABL1 RAD50 ATR BLM BRCA1 LIG1 RAD52 RMI2 RAD51 RMI1 TOP3A WRN RAD9B KAT5 RAD9A RPA1 HUS1 RPA2 EXO1 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 RFC2 BRIP1 ERCC4 MRE11 ATRIP ERCC1 NBN BARD1 RBBP8 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139910 Activation of BMF and translocation to mitochondria BMF MAPK8 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%R-HSA-9635486.4 Infection with Mycobacterium tuberculosis MRC1 LTF TLR2 CTSG SFPQ-1 KPNA1 B2M PGK1 NOS2 HGS ATP6V1H CORO1A RAB7A KPNB1 ENO1 DUSP16 UBA52 GSK3A TRIM27 RPS27A RNF213-2 UBB;UBC RAB5A MAPK1 MAPK3 VPS33B TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 97%933541 TRAF6 mediated IRF7 activation IFNB1-4 TBK1 TANK TRAF2 SIKE1 IRF3 EP300 DDX58 TRAF6 IRF7 RNF135 IFIH1 TRIM25 IKBKE MAVS CREBBP COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 97%2470946 Cohesin Loading onto Chromatin PDS5A STAG2 WAPL SMC1A NIPBL SMC3 MAU2 RAD21 STAG1 PDS5B MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 97%8875878 MET promotes cell motility DOCK7 GAB1 MET ITGB1 ITGA2 RAC1 CRK LAMC3 PTK2 LAMA5 LAMA3 ITGA3 LAMA2 SRC LAMA4 LAMB3 LAMB2 LAMB1 LAMA1 RAP1A RAPGEF1 CRKL LAMC2 LAMC1 TNS4 RAP1B TNS3 HGF METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.9 Metabolism of fat-soluble vitamins LPL AKR1B15;AKR1B10 TTPA APOB APOA2 VKORC1L1 APOA1 APOA4 PNLIP LRP1 TTR LRAT BCO2 LRP2 BCO1 GPC1 LRP8 SDC4 GPC3 APOC3 SDC2 GPC2 RBP4 SDC3 GPC5 RBP2 GPC4 RBP1 HSPG2 APOC2 GPC6 UBIAD1 RETSAT LRP10 RDH11 AGRN LRP12 SDC1 VKORC1 APOM LDLR PLB1 APOE CLPS GPIHBP1 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 97%9856872 Malate-aspartate shuttle SLC25A12 SLC25A22 SLC25A11 GOT2-1 GOT1-1 SLC25A13 MDH1 MDH2 SLC25A18 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 97%8850843 Phosphate bond hydrolysis by NTPDase proteins ENTPD8 ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%8980692 RHOA GTPase cycle SRGAP1 STOM FMNL3 ACTC1;ACTG2 RASGRF2 SNAP23 ARHGAP8;PRR5-ARHGAP8 TAGAP PLEKHG3 PLEKHG4 PLEKHG6 ROCK2 IQGAP1 ROCK1 ARHGAP5 PCDH7 ARHGAP21 FLOT2 LBR OPHN1 TMPO PLEKHG5 ARHGAP35 KTN1 VANGL1 ARAP1 TMEM87A RHOA DEPDC1B KALRN SCFD1 NET1 VAPB ANLN FAF2 AKAP13 C1QBP STBD1 VAV3 CCDC115 TRIO TFRC ERBIN VAV1 VAV2 PREX2 PREX1 ARHGEF3 ARHGEF4 RACGAP1 ARHGEF1 STARD8 ARHGEF2 BCR ARHGEF7 ARHGEF5 DAAM1 NGEF IQGAP3 PGRMC2 EMC3 ABR STARD13 BCAP31 JUP MCAM CAVIN1 CAV1 MYO9B MYO9A ACBD5-1 DLC1 ARHGAP9 ARHGAP1 ARHGAP6 TJP2 ARHGAP4 RTKN GMIP ARHGAP39 CIT DOCK2 ARHGAP44 ARHGAP42 ARHGDIA VAMP3 ARHGDIB PIK3R2 PKN3 ARHGEF40 PIK3R1 ARHGAP45 LMAN1 ARHGEF25 ARHGEF28 ARHGAP19 STX5 ARHGAP18 YKT6 FARP1 ARHGAP22 ARHGAP20 MCF2 HMOX2 DEF6 RHPN2 ECT2 ARHGAP29 MACO1 ARHGAP28 ARHGAP26 ARHGAP24 ARHGAP23 DIAPH1 PLD1 AAAS ARHGAP32 PKN2 ARHGAP31 PKN1 ARHGAP30 DIAPH3 TIAM1 SOWAHC ARHGEF10L FAM13A MCF2L STK10 FLOT1 SLK ARHGEF11 ARHGEF10 ARHGEF12 ABCD3 ATP6AP1 ARHGEF15 ARHGEF17 TEX2 ARAP2 ARHGEF19 ARHGEF18 ARAP3 ARHGAP10 DDRGK1 ARHGAP11A-1 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.4 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known ACTL6A CSNK2A2 SMARCC1 SMARCC2 CSNK2A1;CSNK2A3 CBFB CSNK2B BMI1 RUNX1 SMARCE1 RING1 PCGF5 PBRM1 RYBP RNF2 YAF2 ACTL6B SMARCA2 SMARCA4 CBX8 AUTS2 CBX6 PHC2 PHC1 HIPK2 CBX4 ARID1A EP300 CBX2 ARID1B PHC3 SMARCD1 SMARCB1 SMARCD2 ARID2 SMARCD3 RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs MYL6 KLK3;KLK2 KDM4C-1 YWHAG MYH14 PAK1 MYH11 RAC1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MYH10 PPP1R12A RHOA MYL12B YWHAB H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 MYH9 PKN2 H2BC5 PKN1 H2BC21 H2BC1 KDM1A SFN YWHAZ AR YWHAQ PPP1R12B YWHAH H2AC20 PDPK1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 PKN3 RHOC YWHAE RHOB PPP1R14A NCOA2 PPP1CB H2AC14 CDC25C LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 97%8964572 Lipid particle organization HSD17B13 CIDEC CIDEA FITM1 FITM2 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 97%1237044 Erythrocytes take up carbon dioxide and release oxygen CYB5R1 CYB5R4 CYB5RL HBA2;HBA1 CA1 AQP1 CA2 CA4 HBD;HBB CYB5R2 RHAG SLC4A1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling FLNA GP1BA GP5 GP9 YWHAZ RAF1 PIK3R1 VWF GP1BB CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall SOS1 EPCAM APOB SELL JCHAIN YES1 SLC7A6 GP6 SLC7A7 SLC7A8 SLC7A9 CD84 SDC4 SDC2 SDC3 ITGB2 FCER1G LCK TSPAN7 SDC1 PICK1 PLCG1 PECAM1 JAM2 JAM3 ITGA6 CD47 ATP1B2 ATP1B1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 GRB7 SLC7A5 GPC1 SIRPA;SIRPB1;SIRPG ITGAX ITGA3 SLC16A1 PF4;PF4V1-1 ITGAM MERTK VPREB3 VPREB1 SLC16A8 ITGB1 SLC16A3 FCAMR IGLL5;IGLL1 GYPC CD99L2 GLG1 INPP5D SELE ITGAV SELP ESAM SPN CD48 SELPLG CD2 MAG CD244 SLC3A2 BSG CAV1 ATP1B3-1 F11R FN1 PPIA PIK3R2 PIK3CB HRAS PIK3R1 FYN NRAS PIK3CA PTPN11 PTPN6 TGFB1 ANGPT4 CD74 ANGPT2 ANGPT1 DOK2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A MMP1 TEK GRB14-1 SHC1-1 ITGB3 PROS1 THBD CD177 LYN ITGAL CD44 TREM1 F2 MIF ITGA4 PPIL2 PROCR CXADR ITGA5 L1CAM JAML PROC OLR1 SLC7A11 SLC7A10 CD99 GAS6 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 97%9614657 FOXO-mediated transcription of cell death genes BCL2L11 FASLG DDIT3 BBC3 FOXO4 FOXO3 STK11 EP300 FOXO1-1 PINK1 NFYA-1 BCL6 NFYB NFYC CREBBP CITED2 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 97%209560 NF-kB is activated and signals survival TRAF6 NGF NFKB1 UBB;UBC IKBKB RELA NGFR SQSTM1 NFKBIA IRAK1 RPS27A UBA52 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 97%9759194 Nuclear events mediated by NFE2L2 TXN RBX1 MAFG BCL2 BCL2L1 SOD3 GSK3B ABCF2-H2BE1;ABCF2 PGD SQSTM1 CREBBP CHD6 SP1 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 SRXN1 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 EGF PSMD3 ME1 PRDX1 PSMB1 PSMD1 ADRM1 MYC PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PDGFA PSMC6 PSMA4 MAFK AREG BTRC PSMC3 NFE2L2 PSMA1 PRKAA2 NQO1 HMOX1 PSMC4 PSMC1 SKP1 CCL13;CCL2 TXNRD1 G6PD ABCG2 IDH1 GSTA3;GSTA1 UBA52 KEAP1 ATF4 CUL1 RELA TALDO1 GCLC GCLM EP300 TKT RPS27A CDKN2A BACH1 UBB;UBC NFKB1 SLC7A11 ABCC3 ABCC1 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins NUP133 PML NUP107 MDM2-2 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 PIAS4 NUP205 NUP42 UBE2I AAAS NUP160 NUP43 NUP85 TPR NUP214 PIAS1 NUP88 TRIM27 RAE1 RANBP2 NUP155 SUMO1 NUP153 NUP35 NUP62 NUP37 VHL NDC1 SEC13 OAS ANTIVIRAL RESPONSE%REACTOME%R-HSA-8983711.5 OAS antiviral response FLNA RNASEL OASL OAS1 ABCE1 PDE12 OAS3 DDX58 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620916 VxPx cargo-targeting to cilium CNGA2 CNGA4 ARF4-1 EXOC8 EXOC7 RAB8A EXOC4 EXOC3 RAB11FIP3 EXOC6 EXOC5 RAB3IP EXOC2 CNGB1 EXOC1 ASAP1 PKD2 RHO PKD1 GBF1 RAB11A SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection RPS14 RPS17 TBK1 RPS16 RPS19 RPS18 CHMP3 RPS11 CHMP6 CHMP7 RPS10 RPS13 RPS12 MAP1LC3B2;MAP1LC3B-1 ST6GAL1 MOGS ACE2 PIK3R4 ST3GAL4 SFN RIPK3 SMAD2;SMAD3 ST3GAL1 ST3GAL2 ST3GAL3 PARP16 PYCARD PARP14 PARP10 RPS25 RPS27 CASP1 RPS29 RPS20 RPS21 RPS24 RPS23 IFIT1 YWHAE IKBKE IFIT3 IFIT2 TOMM70 PARP6 PARP4 SFTPD HNRNPA1-1 PSMC6 PARP9 YWHAG PARP8 EEF1A1 PPIB SIKE1 DDX58 CANX TLR7 TMPRSS2 RPS27L IFIH1 RPS15A TRIM25 YWHAB RPS3 MGAT1 UBA52 RPS2 YWHAZ MPP5 STING1 FAU EP300 VCP-1 RPS27A KPNA2 UBB;UBC RPS9 RPS7 RPS8 RPS5 RPS6 RPSA ZCRB1 NPM1-2 DDX5 BCL2L1 TKFC PCBP2 IRAK2 NLRP3 GSK3B KPNB1 UVRAG CAV1 UBE2I MAVS SP1 GSK3A ST6GALNAC2 PRKCSH ITCH RPS4X SUMO1 YWHAQ YWHAH PDPK1 RPS3A FKBP1A IRF3 TRAF3 PPIA SMAD4 TRAF6 PIK3C3 ST6GALNAC3 ST6GALNAC4 BECN1 GANAB VHL GALNT1 CTSV;CTSL BST2 RUNX1 CHMP4C CHMP4B CHMP4A RCAN3 NFKBIA PPIH PPIG RELA NMI CHMP2B CHMP2A NFKB1 RB1 RPS15 GSD 0%REACTOME DATABASE ID RELEASE 97%3858516 GSD 0 GYG2 GYS2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME DATABASE ID RELEASE 97%9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence MCM2 BRCA1 TERT MCM5 LIG1 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME%R-HSA-9762114.3 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC RBX1 PSMC3 NFE2L2 PSMA1 PSMC4 PSMC1 SKP1 GSK3B UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 97%1638074 Keratan sulfate keratin metabolism GLB1L2 GNS SLC35D2 GLB1L GLB1 FMOD CHST6 LUM B4GALT6 B4GALT4 B4GALT5 PRELP KERA CHST1 OGN ST3GAL4 CHST2 ST3GAL1 ST3GAL2 ST3GAL3 CHST3 OMD ACAN GALNS B4GAT1 B4GALT2 B4GALT3 B4GALT1 B3GNT7 B3GNT4 B3GNT3 B3GNT2 HEXB HEXA GLB1L3 ST3GAL6 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport SLC22A2 SLC22A1 SLC22A18 SLC22A3 RUNX1 SLC14A1 SLC14A2 SLC47A1 SLC25A26 SLC22A15 SLC22A16 RSC1A1 SLC22A4 SLC22A5 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 97%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 97%2219530 Constitutive Signaling by Aberrant PI3K in Cancer FGF20 FLT3LG FGF23 PDGFB CD19 TGFA PIK3R3 CD28 PIK3R6 PIK3R5 STRN GAB2 CD86 FGF2 KLB CD80 PDGFRB FGF19 FGFR4 IRS2 TRAT1 FLT3 PIK3AP1 ESR1 LCK SRC PIK3CD PIK3CG IRS1 PIK3R2 EGF ESR2 PIK3CB ERBB2 EGFR PIK3R1 PDGFRA FYN FGF6 HGF FRS2 GAB1 PIK3CA MET PTPN11 AREG RAC1 NRG1 NRG2 FGF7 EREG BTC FGF22 FGF3 NRG3 FGF10 NRG4 HBEGF KIT NTRK3 EPGN NTRK2 BDNF NTF3 RHOG VAV1 FGF1 FGF4 FGF16 FGF9 FGF18 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 97%8876198 RAB GEFs exchange GTP for GDP on RABs DENND6B RIN3 RAB38 ULK1 DENND6A RIN1 RIN2 AKT2 AKT3 RAB5B RAB6B CCZ1;CCZ1B TRAPPC3 TRAPPC1 ANKRD27 DENND4B DENND4A TRAPPC4 TRAPPC5 DENND4C HPS1 RAB39A HPS4 RAB27A RAB39B RAB27B RAB9A TRAPPC8 TRAPPC9 MON1A RAB9B MON1B DENND1C DENND1B GDI1 DENND1A GDI2 RAB8B DENND2D DENND2C TRAPPC2;TRAPPC2B DENND2B DENND2A RAB3IL1 TRAPPC6A TRAPPC6B RAB7B RAB3IP RAB1A RAB5A YWHAE RAB1B RAB21 ALS2CL CHML RIC1 TRAPPC10 RAB6A RGP1 RAB10 RAB13 RAB18 RAB3GAP2 RAB3GAP1 RAB8A CHM SBF1 SBF2 RAB7A RAB14 AKT1 RAB3A DENND5B RABGEF1 RINL RAB5C TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TRAPPC2L ALS2 GAPVD1 RAB32 RAB31 RAB35 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation SNAI1 FGFR1 EOMES TBXT DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 97%5632927 Defective Mismatch Repair Associated With MSH3 MSH2 MSH3 PTK6 EXPRESSION%REACTOME DATABASE ID RELEASE 97%8849473 PTK6 Expression PTK6 HIF1A PELP1 NR3C1 EPAS1 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 97%388844 Receptor-type tyrosine-protein phosphatases IL1RAPL1 SLITRK6 LRRC4B PPFIA1 PPFIA4 PPFIA3 PPFIBP1 PPFIA2 PTPRF SLITRK3 SLITRK5 PTPRD PPFIBP2 SLITRK2 NTRK3 SLITRK1 PTPRS SLITRK4 IL1RAPL2 G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition FBXL18 CCNA2-1 TUBG2 CCNA1 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 PSMD12 PSMD11 PSMD14 CDC25A PSMD13 HMMR CDC25B PSMA7 PSMD8 MYBL2 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 YWHAE CEP57 CETN2 ADRM1 CEP164 CCP110 AKAP9-1 PSMC2-1 PPP1CB PSMA2-1 MAPRE1-1 PSMA5 SEM1 TPX2 PRKACA-1 ACTR1A PSMA6 TUBA1A PSMC5 PPP2R1A PSMA3 CNTRL PSMC6 CEP250 PSMA4 NEK2 BTRC CDKN1A PSMC3 CEP290 PSMA1 YWHAG PSMC4 RAB8A PSMC1 SKP1 CDK5RAP2 HSP90AA1 OPTN-1 HJURP CEP135 PPP1R12A BORA MIS18BP1 FBXW11 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 XPO1 CEP63 AJUBA UBA52 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 CDK2 HAUS8 PRKAR2B PPP2CB;PPP2CA HAUS7 CEP70 CEP72 EP300 CEP192 RPS27A PHLDA1 PCNT PPP2R1B OBI1 CEP76 LCMT1 CLASP1 PPME1 UBB;UBC CEP78 TICRR PLK4 OFD1-1 FOXM1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 CDK11A;CDK11B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ CDC25C ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E FBXL7 CEP41 CEP43 RBX1 CDK7 GTSE1 FKBPL MNAT1 PPP2R3B HSP90AB1 PKMYT1 TP53 WEE1 SGO1 RBBP4 CENPF LIN54 LIN37 LIN9 LIN52 PPP2R2A;PPP2R2D FZR1 CCNH TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.8 Transcription from mitochondrial promoters POLRMT MTERF1-1 TFB2M TFAM-1 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 97%73893 DNA Damage Bypass DTL RBX1 UBE2B UBA7 ISG15 UBE2L6 POLK RAD18 POLE TRIM25 RFC1 POLD1 PCNA UBA52 POLI POLH DDB1 USP10 PCLAF USP43 RPA1 SPRTN RPA2 NPLOC4 UFD1 POLD3 POLD4 POLD2 RPA3 VCP-1 USP1 RPS27A RFC5 RFC3 RFC4 POLE4 CUL4A UBB;UBC RFC2 REV1 POLE2 MAD2L2 RCHY1 REV3L POLE3 CUL4B WDR48 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNA7;CHRFAM7A CHRNA2-1 CHRNA1 CHRNB4 CHRNA9 CHRNA3 CHRNB3 CHRNA5 CHRND CHRNA4 CHRNA6 CHRNG CHRNE RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833110 RSV-host interactions MED30 TLR2 MED13L RBX1 MED1 IFNAR1 CDK8 MED4 MED6 MED7 BCAP31 CCNC-1 SDC4 MAVS SDC2 CREBBP SDC3 HSPG2 IRF3 TLR6 SDC1 MED16 MED17 MED12 MED14 MED13 BECN1 MED10 MED8 JAK1 MED9 CUL5 MED19 MED15 MED18 IFNB1-4 MED11 TYK2 MED27 TLR3 MED23 LY96 DDX58 MED26 MED24 CDK19 MED29 TLR7 ISG15 UBE2L6 CD14 HERC5 MED22 MED20 TLR4 IFIH1 MED25 TRIM25 GPC1 ARIH1 MED21 GPC3 H2BC15;H2BC3;H2BC11;H2BC12 GPC2 GPC5 UBA52 CX3CR1 GPC4 GPC6 CLEC4M;CD209-2 STAT2 MED31-1 AGRN EP300 RPS27A MED28-1 MAP1B UBB;UBC ELOC-1 EIF2AK2 ELOB SPERM MOTILITY AND TAXES%REACTOME%R-HSA-1300642.2 Sperm Motility And Taxes HVCN1 CATSPER1 KCNU1 CATSPER3 CATSPERB CATSPER2 CATSPERD CATSPER4 CATSPERG ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME DATABASE ID RELEASE 97%9958825 Activation of STAT3 by cadherin engagement STAT3 CTNNA1 CDH1 JUP JAK2 PSMD12 VCL RNF19B PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 SRC PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 CDC42 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 IL6ST PSMB1 PSMD1 JAK1 ADRM1 CTSS PSMC2-1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PSMC5 TYK2 PSMA3 CTNND1 PSMC6 PSMA4 FARP2 CBLL1 PSMC3 PSMA1 PSMC4 CDH11 PSMC1 BIRC2 CTNNB1 RAC1 CTSB CTSV;CTSL ELMO1 DOCK1 IL6R UBA52 TIAM1 RELA TRAF7 RPS27A UBB;UBC NFKB1 IL6 VAV2 HACE1 ARHGEF4 DEFECTIVE F8 SULFATION AT Y1699%REACTOME DATABASE ID RELEASE 97%9674519 Defective F8 sulfation at Y1699 TPST2 TPST1 F8 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling MTOR RRAGA RRAGC RRAGB SLC38A9 MLST8 FKBP1A RRAGD EIF4E RPTOR EIF4B EEF2K LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 AKT1S1 RHEB RPS6 EIF4EBP1 EIF4G1 INTERLEUKIN-37 SIGNALING%REACTOME%R-HSA-9008059.4 Interleukin-37 signaling PTPN18 PTPN9 PTPN11 TBK1 SMAD2;SMAD3 PTPN6 PTPN5 PTPN2 PTPN20 PTPN12 STAT3 PTPN23 PTPN7 PTPN14 IL37 CASP1 IL18R1 PTPN13 IL18BP SIGIRR PTPN4 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 97%8878159 Transcriptional regulation by RUNX3 BCL2L11 MDM2-2 WWTR1 HDAC4 CREBBP JAG1 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 SMAD2;SMAD3 LEF1 ZFHX3 RBPJ PSMA7 PSMD8 SRC PSMB6 PSMB7 MAML2 PSMD6 MAML1 PSMB4 PSMD7 SMAD4 PSMB5 SMURF2 PSMB2 SMURF1 TP53 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 MAML3 ADRM1 MYC PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 HES1 PSMC5 PSMA3 SNW1 PSMC6 MAMLD1 PSMA4 CDKN1A PSMC3 PSMA1 TEAD1 PSMC4 TEAD2 PSMC1 TEAD3 KAT2B CTNNB1 TEAD4 BRD2 KAT2A TCF7 FOXO3 TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 TCF7L1 ITGAL UBA52 ITGA4 SPP1 YAP1-1 EP300 TCF7L2 RPS27A CDKN2A UBB;UBC CCN2 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling CDK1 MAPKAPK5 PAK1 PAK3 FOXO1-1 PRKACB-1 CCND3 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 CDC42EP5 PSMB4 PSMD7 CDC42EP3 CDC42 CDC42EP2 PSMB5 PSMB2 RAG2 PSMB3 PSMD2 RAG1 PSMD3 PSMB1 PSMD1 ADRM1 MYC PSMC2-1 PSMA2-1 PSMA5 PRKACA-1 NCOA3 SEM1 PSMA6 JUN PSMC5 PSMA3 DNAJB1 PSMC6 PSMA4 TNRC6C MOV10 TNRC6A-1 PSMC3 PSMA1 AGO4 PSMC4 AGO2 PSMC1 AGO3;AGO1 RAC1 TNRC6B FOXO3 KALRN HSPB1 XPO1 UBA52 PAK2 SEPTIN7 CDC14A CDC14B ETV4 IGF2BP1 MAPK6 MAPK4 RPS27A UBB;UBC PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 97%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex TPTEP2-CSNK1E;CSNK1E PPP1CA CSNK2A2 PER2 CSNK2A1;CSNK2A3 PER1 CDK5 PPP1CC CSNK2B CRY2 CRY1 CSNK1D PPP1CB UREA CYCLE%REACTOME%R-HSA-70635.5 Urea cycle CPS1 ARG1 ARG2 ASL TP53 ASS1 OTC NMRAL1 NAGS SIRT5 SLC25A15 SLC25A2 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias SLC26A2 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) SLC7A9 SLC3A1 GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones INHA INHBE FSHB LHB CGA TSHB INHBB INHBA INHBC PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer FGF20 FLT3LG FGF23 PDGFB CD19 BAD MDM2-2 TGFA PIK3R3 CD28 PIK3R6 AKT2 PIK3R5 STRN AKT3 GAB2 CD86 FGF2 KLB CD80 FOXO1-1 GSK3B PDGFRB FGF19 FGFR4 AKT1S1 IRS2 TRAT1 RPS6KB2 FLT3 PIK3AP1 ESR1 GSK3A PRR5 LCK PDPK1 PTEN MLST8 SRC PIK3CD PIK3CG MAPKAP1 IRS1 PIK3R2 EGF ESR2 PIK3CB ERBB2 NR4A1 EGFR PIK3R1 PDGFRA FYN FGF6 HGF FRS2 GAB1 PIK3CA MET PTPN11 MTOR AREG CDKN1A CDKN1B RAC1 CHUK FOXO4 NRG1 FOXO3 NRG2 FGF7 EREG BTC FGF22 FGF3 NRG3 FGF10 NRG4 HBEGF KIT NTRK3 EPGN AKT1 TSC2 NTRK2 BDNF RICTOR NTF3 RHOG VAV1 CASP9 FGF1 FGF4 FGF16 FGF9 FGF18 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%774815 Nucleosome assembly CENPT CENPU RBBP4 NPM1-2 CENPN-2 KNL1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 HJURP RSF1 CENPH MIS18BP1 OIP5 RBBP7 CENPW CENPI MIS18A CENPK CENPL CENPM H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 CENPO CENPP H2BC21 H2BC1 CENPQ SMARCA5 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CENPX H2AC4 CENPA CENPC RUVBL1 ITGB3BP CENPS-CORT;CORT;CENPS H2AC14 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 97%1482839 Acyl chain remodelling of PE PLAAT1 PLA2G4A PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLA2G1B PLBD1 PLA2R1 ABHD4 PLA2G3 PLA2G5 PLA2G10;LOC100652777 PLA2G2F PLA2G6 PLA2G2D PLA2G2E PNPLA8 MBOAT1 MBOAT2 LPCAT4 LPCAT3 PLA2G2A-1 PLA2G12A PLA2G4F JMJD7-PLA2G4B;PLA2G4B PLA2G4D PLA2G4E DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 97%1168372 Downstream signaling events of B Cell Receptor (BCR) PSMD12 PSMD11 PSMD14 PSMD13 PPP3R1 PSMA7 PSMD8 PSMB6 FKBP1A PSMB7 PSMD6 PSMB4 NFATC2 PSMD7 PPIA NFATC1 PSMB5 PSMB2 PSMB3 PPP3CA PSMD2 PPP3CB PSMD3 PSMB1 PSMD1 HRAS ADRM1 PSMC2-1 PSMA2-1 PSMA5 NRAS SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NFKBIB BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK REL FBXW11 CALM3;CALM1 RASGRP3 NFKBIE IKBKB CARD11 BCL10 IKBKG RASGRP1 MALT1 UBA52 NFKBIA NFATC3 CUL1 RELA RPS27A UBB;UBC NFKB1 MAP3K7 PRKCB SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG PTPMT1 PLD4 PLD6 PLD1 CDS2 PLD3 PLD2 PGS1 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME DATABASE ID RELEASE 97%5619094 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 METHYLATION%REACTOME%R-HSA-156581.6 Methylation MTR-1 COMT NNMT MTRR MAT2B N6AMT1 AHCY TPMT TRMT112 MAT2A GSTO1 AS3MT MAT1A CYP1A2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170984 ARMS-mediated activation NGF RAP1A YWHAB BRAF KIDINS220 CRK NTRK1 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 97%9630791 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDK4 CDKN2A FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion PLCB1 PLCB2 GNA14 FFAR1 GNA15 CD36 GNAQ GNA11 PLCB3 ACSL4 ACSL3 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 97%9694548 Maturation of spike protein MGAT4C MGAT4B FUT8 CANX MAN2A1 ZDHHC20 ST6GAL1 OST4 MOGS MGAT5 RPN2 OSTC STT3A RPN1 MGAT1 STT3B ST3GAL4 MGAT2 ST6GALNAC2 PRKCSH ST3GAL1 MGAT4A-1 ST3GAL2 ST3GAL3 EDEM2 ZDHHC9 DDOST DAD1 TUSC3 MAN1B1 ST6GALNAC3 ST6GALNAC4 MAGT1 ZDHHC5 GANAB ZDHHC8 ZDHHC2 GOLGA7-1 ZDHHC3 TMEM258 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation PMPCA MICU2 NDUFS1 ALDH1B1 HTRA2 TFAM-1 TWNK ACADSB STAR SSBP1 FECH ACAT1 UQCRQ UQCRC2 ACO2 SHMT2 ALAS1 MRPS10 COX4I1 TIMM17A-1 CHCHD2 ACAD8 COX5B MRPL32 OPA1 SLC25A5 ACOT2;ACOT1 NADK2 OXSM ECH1 COX5A TIMM22 ATP5PF CLPX ATP5PD ME2 CLPP TIMM10 SLC25A6 LDHD ALDH18A1 PRELID1 LONP1 PRKACA-1 ATP5PO NDUFA13 HSPD1 HMGCS2 ATP5F1A IDH3A ATP5F1B CS STARD7 MRPS2 HADH NDUFB6 ATP5F1C PDHB ARG2 PCCB ATP5MG OGDH HSD17B10 IDH2 HSPA9 ECI1 NDUFV3 GLUD1;GLUD2 BDH1 DLD NDUFV1 MRPL12 FH ALDH2 PDK1 DBT OXCT1-1 SPG7 PDHA1 MDH2 SUCLG2 IARS2 AFG3L2 SMDT1 YME1L1 NDUFS3 OMA1 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease FGF20 NCBP1 BCR SOS1 FGF23 CEP43 STAT3 GAB2 FGF2 FGFR4 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I LRRFIP1 FGFR1OP2 STAT5A STAT5B NCBP2-1 PLCG1 HRAS PIK3R1 FGF6 NRAS FRS2 CPSF6 GAB1 PIK3CA FGFR3 FGFR2 FGFR1 TRIM24 POLR2E FGF7 POLR2F GTF2F1 POLR2H GTF2F2 FGF22 FGF3 BAG4 FGF10 POLR2L ERLIN2 STAT1 MYO18A POLR2J;POLR2J2;POLR2J3 ZMYM2 CUX1 FGF1 FGF4 FGF16 FGF9 FGF18 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 97%9759785 Diseases of propionyl-CoA catabolism MMAA MMUT DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 97%5579019 Defective FMO3 causes TMAU FMO3 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade TBK1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 RIPK3 APP NFKB2 IKBKE RIPK2 JUN PPP2R1A MAPK7 BTRC UBE2D3-1 SKP1 BIRC2 CHUK BIRC3 OPTN-1 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 TANK MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 IRF3 TRAF3 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 PTPN11 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP TRAF2 TICAM1 CASP8 LRRC14 USP14 RIPK1 NLRC5 CD14 TIFA FADD HMGB1-1 TLR4 UBE2D3;UBE2D2 NFKBIA UBE2D1 RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 SIGNALING BY LTK IN CANCER%REACTOME%R-HSA-9842640.1 Signaling by LTK in cancer CLIP1 PIK3CA PIK3R2 PIK3CB MAPK1 PIK3R1 MAPK3 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC PFDN6 TUBA1A CCT8 TUBA3E;TUBA3C-1 CCT7 ACTB-1 CCT5 CCT4 CCT6A TUBA4A CCT6B PFDN4-1 TUBA1C TUBB1 CCT3 CCT2 TUBB2B;TUBB2A VBP1 TCP1 TUBB4B PFDN1 PFDN2 TUBB4A;TUBB;TUBB8B;TUBB8 PFDN5 TUBB3;TUBB6 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.5 ADP signalling through P2Y purinoceptor 12 GNB3 GNGT1 GNB5 GNG10 GNG2 GNG5 GNG4 P2RY12 GNG8 GNAT3 GNAI1 GNAI3 GNAI2 GNG13 GNB2 GNB1 GNB4 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells EGF AREG TGFA GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling SOS1 NRG1 NRG2 EREG BTC EGF NRG3 ERBB2 NRG4 EGFR HRAS HBEGF NRAS IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) TLR5 MYD88 TLR10 IRAK4 MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.5 MHC class II antigen presentation DYNC1LI1 SPTBN2 DYNC1LI2 KIF18A CTSO ACTR1B CTSH CTSF CTSE CTSC HLA-DMA HLA-DMB SEC31A KIF11 DYNC1I1 KIF15 CAPZA3 CTSA ACTR10 CAPZB HLA-DOA HLA-DOB SAR1B KIF3A KIF23 KIF22 DCTN6 DCTN5 HLA-DPB1-1 DCTN4 KIF2A HLA-DQB2;HLA-DQB1 OSBPL1A HLA-DPA1 RILP KIF2C HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 KIF2B DCTN1 HLA-DRA SEC23A CENPE LGMN KIF26A CAPZA1 CTSS CAPZA2 SEC24B ACTR1A SEC24A CTSK ARF1 SEC24C CTSD CTSB LAG3 CTSV;CTSL CANX CD74 RAB7A CLTC CLTA AP2A1 AP2B1 DYNC1I2 AP2A2 AP1G1 DCTN2 DNM1 AP1S2 DNM2 DCTN3 AP1S1 DNM3 SEC24D-1 AP1S3 AP2S1 KIF5B KIF5A SH3GL2 AP1B1 KIFAP3 KIF4B;KIF4A KIF20A KLC1 DYNC1H1 AP1M2 KLC4 KLC3 AP1M1 KLC2 RACGAP1 IFI30 KIF3B SEC13 KIF3C SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%8847453 Synthesis of PIPs in the nucleus PIP4P1 PIP4K2A PIP4K2B PIP4K2C FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.4 Formation of editosomes by ADAR proteins ADAR ADARB1 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-HSA-392851.5 Prostacyclin signalling through prostacyclin receptor GNB3 GNGT1 GNB5 PTGIR GNG10 GNAS-1 GNG2 GNG5 GNG4 GNG8 GNG13 GNB2 GNB1 GNB4 CDC42 GTPASE CYCLE%REACTOME%R-HSA-9013148.5 CDC42 GTPase cycle SRGAP3 SRGAP2 GNA13 SRGAP1 STOM FMNL3 FMNL1 MAP3K11 FMNL2 RASGRF2 SNAP23 TAGAP PLEKHG3 PLEKHG4 PLEKHG1 PLEKHG2 ARFGAP3 ARFGAP2 WASL PARD6A IQGAP1 ARHGAP5 CDC42BPB ARHGAP21 BAIAP2 CDC42BPA DOCK7 CPNE8 LBR OPHN1 TMPO ARHGAP35 SCRIB SPATA13 KTN1 VANGL1 ARAP1 DEPDC1B DOCK10 DOCK11 SH3PXD2A GIT1 VAV3 TRIO RALBP1-1 TFRC WIPF1 LAMTOR1 WIPF2 ITSN1 WIPF3 STEAP3 FNBP1L VAV2 PREX2 PREX1 WDR91 ARHGEF4 RACGAP1 FNBP1 STARD8 BCR ARHGEF7 ARHGEF5 WDR81 ARHGEF6 DAAM1 NGEF WAS DOCK6 IQGAP2 PAK1 IQGAP3 DOCK9 DOCK8 ABR PAK3 PAK5 PAK4 STARD13 JUP GIT2 CAV1 MYO9B DLC1 CDC42SE2 ARHGAP9 ARHGAP1 ARHGAP4 BUB1B-PAK6;PAK6 ARHGDIG GMIP ARHGAP39 ARHGAP44 CDC42EP5 CDC42EP4 SYDE1 CDC42EP3 CDC42 ARHGAP42 CDC42EP2 CDC42EP1 ARHGDIA VAMP3 ARHGDIB PIK3R2 KCTD3-1 PIK3R1 FGD1 ARHGAP45 FGD2 FGD3 FGD4 ARHGEF26 ARHGEF25 CHN1 YKT6 ARHGAP17 FARP1 ARHGAP22 ARHGAP20 MCF2 DEF6 ECT2 ARHGAP29 ARHGAP27 RAB7A SHKBP1 ARHGAP26 ARHGAP24 ARHGAP33 PLD1 ARHGAP32 ARHGAP31 ARHGAP30 PAK2 DIAPH3 TIAM1 DNMBP FAM13B MCF2L ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF16 ARAP2 ARHGEF19 ARAP3 ARHGAP10 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665686 Signaling by ERBB2 TMD JMD mutants SOS1 HSP90AA1 NRG1 NRG2 EREG BTC EGF CDC37 SHC1-1 ERBIN NRG3 ERBB2 NRG4 PLCG1 EGFR HRAS HBEGF NRAS CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.6 Cardiac conduction SCN1A KCNJ2 KCNJ12;KCNJ18 KCNE2 KCNE3 KCNE4 KCNJ4 KCNE5 FGF14 FGF13 FGF12 WWTR1 FGF11 ABCC9 SCN3B SCN3A KCNK5 KCNK10 SCN2A KCNK12 SCN2B CACNG6 KCNJ14 KCNK13 KCNK15 TNNI3 KCNK16 KCNK18-1 RANGRF KCNK17 CACNB2 KCNK2 CACNA2D2 KCNK4 SCN9A NPPA SCN8A ITPR1 ITPR2 ITPR3 SCN5A SCN4A SCN4B SCN7A KCNK6 KCNK7 CACNG7 KCNK1 NKX2-5 AKAP9-1 PRKACA-1 KAT2B ATP1B2 ATP1B1 KCNJ11 CACNG8 CACNG4 STIM1 ORAI2 KCND1 ORAI1 KCND2 KCNIP1 HIPK1 KCND3 KCNIP2 KCNIP4 HIPK2 CACNA1C FXYD4 FXYD3 GATA4 FXYD1 FXYD6 RYR1 RYR2 RYR3 CLIC2 KCNK9 TRDN KCNK3 ASPH NOS1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 KCNIP3 ATP1B3-1 FXYD2;FXYD6-FXYD2 FKBP1B MME NPR1 NPR2 NPPC CORIN CAMK2B TRPC1 CAMK2D CAMK2A CAMK2G SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 KCNQ1 SCN11A SCN10A DMPK KCNE1;KCNE1B CES1 AHCYL1 TBX5 KCNA5 KCNH2 CACNB1 SCN1B CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559583 Cellular Senescence MINK1 ETS2 EP400 CCNA2-1 HMGA2 CCNA1 CABIN1 BMI1 ETS1 KDM6B ASF1A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RING1 KAT5 RNF2 UBN1 CDKN2D CDKN2C CBX8 ERF H2AC20 TNIK CBX6 PHC2 H2AB2;H2AB3;H2AB1 IGFBP7 PHC1 EZH2 CBX4 CBX2 PHC3 TFDP1 TFDP2 E2F1 E2F3 JUN ATM MAP4K4 CXCL8 MAPK7 CDKN1A CDKN1B H2AJ FOS SUZ12 CDKN2B H2BC5 UBA52 H2BC1 MAPKAPK2 CDK4 CDK2 ID1 RPS27A RPS6KA3 RPS6KA2 H2AC4 UBB;UBC RPS6KA1 MRE11 MAP2K3 MAPK14 MAP2K4 MAPK11 MAPKAPK3 NBN MAPK9 MAPK8 MAP2K7 MAPK10 CDK6 MAPKAPK5 TXN MDM2-2 STAT3 ACD TINF2 MAP2K6 TERF2 POT1 TERF2IP TERF1-1 SP1 MDM4 H2BC21 EED H2AZ2;H2AZ1 IL1A TP53 IFNB1-4 E2F2 TNRC6C RAD50 MOV10 TNRC6A-1 AGO4 RBBP4 AGO3;AGO1 HIRA TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 LMNB1 H2BC15;H2BC3;H2BC11;H2BC12 CEBPB ANAPC15 H1-0 ANAPC16 H1-3 UBE2D1 H1-2 H1-5 RELA ANAPC10 H1-4 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 CDKN2A UBE2C UBE2E1 MAP3K5 NFKB1 IL6 UBE2S CDC16 CCNE2 ANAPC4 MAPK1 CCNE1 ANAPC5 RB1 ANAPC1 MAPK3 ANAPC2 EHMT2 EHMT1 H2AC14 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 97%5693579 Homologous DNA Pairing and Strand Exchange RAD17 ATM RAD50 ATR BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN RAD9B KAT5 CHEK1 RAD51B RAD9A RAD51C RPA1 HUS1 RPA2 EXO1 BRCA2 RAD51AP1 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 XRCC2 RFC2 XRCC3 PALB2 BRIP1 MRE11 ATRIP NBN BARD1 RBBP8 SEM1 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane PIKFYVE ARF1 FIG4 PI4KA SACM1L PI4KB INPP5E PI4K2B PIK3C3 OCRL TPTE;TPTE2 PIK3C2G PIK3C2A PI4K2A VAC14 PIK3R4 DEFECTIVE MTRR CAUSES HMAE%REACTOME%R-HSA-3359467.4 Defective MTRR causes HMAE MTR-1 MTRR MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins VPS37C VPS37D VPS37A VPS37B RPS27A NMT2 UBAP1 UBB;UBC VPS28 TSG101 MVB12B MVB12A UBA52 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 97%9632693 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDK4 CDKN2A NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 PSEN2 APH1A APH1B NOTCH3 YBX1 PSEN1 PSENEN NCSTN TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%167246 Tat-mediated elongation of the HIV-1 transcript NCBP1 CCNT1 CDK7 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 NCBP2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%9932444 ATP-dependent chromatin remodelers DPF1 PHF5A DPF2 SNRPD2 DPF3 SNRPD1 SMARCC1 SNRPN SMARCC2 SNRPD3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP SS18L1 SNRPE-2 SMARCA2 SMARCA4 H2AC20 H2AB2;H2AB3;H2AB1 SSRP1 CBX3-1 SS18 ACTL6A MAFK NFE2L2 CTNNB1 H2AJ CDC73 TCF12 LEO1 AXIN2 SF3B1 MBD3 H2BC5 MBD2 H2BC1 BRD7 GATAD2B GATAD2A CHD9 EP300 H2AC4 CHD2 TCF4 SNRPF SNRPB CTR9 RTF1 ACTB-1 MYOG PAF1 FBP1 DHX15 MYOD1 UBE2I CHD4 G6PC1 CHD3 CHD8 CHD7 BCL7A CHD6 CTCF H2BC21 NKD2 FAM124B BCL7C IGF2 BCL7B PWWP2B DDX46 DDX42 CHD5 IKZF1 WDR5 IKZF2 SUMO1 RBM17 IKZF3 PHF6 MBD3L1 ZMYND8-1 PWWP2A H2AZ2;H2AZ1 ADNP2 ARID1A ZNF687 ARID1B TCF19 ADNP ZNF592 ZNF827 SMNDC1 CBX1 U2SURP NR2F2 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 CDK2AP2 CDK2AP1 ZNF532 DKK2 SMARCD1 BCL11B PHF10 SMARCD2 SNRPG-2 HDAC2 SMARCD3 NR2C2 HDAC1 SF3B4 SF3B5 MTA1 SF3B2 SF3B3 RBBP4 NQO1 SF3B6 SF3A3 SF3A1 SUPT16H H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SF3A2 BICRAL BICRA BRD9 RBBP7 MTA2 MTA3 SMARCE1 CHERP H2BC15;H2BC3;H2BC11;H2BC12 PBRM1 ACTL6B PUF60 SNRPB2 BCL11A SNRPA1 WDR61 SMARCB1 PCK1 ARID2 H2AC14 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 97%380972 Energy dependent regulation of mTOR by LKB1-AMPK MTOR PRKAA2 PRKAG1 SLC38A9 PRKAG3 RPTOR STK11 PRKAB2 RHEB TSC2 TSC1 PRKAB1 CAB39 PPM1A RRAGA RRAGC RRAGB MLST8 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 PRKAA1 CAB39L STRADA PRKAG2 STRADB VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5619101 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 97%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs ABL1 GATA3 CDK7 MNAT1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC21 PSMD12 PSMD11 PSMD14 PSMD13 ITCH LMO1 PSMA7 H2AC20 LMO2 LDB1 PSMD8 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 TP73 PSMC3 PSMA1 PSMC4 PSMC1 H2AJ TCF12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TAL1 CBFB RUNX1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 MYB UBA52 H2BC1 YAP1-1 RPS27A H2AC4 UBB;UBC GATA2 GATA1 CCNH KMT2A SPI1 H2AC14 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage HPRT1 ADAL TK2 PNP-1 UCK1 TK1 APRT DGUOK TYMP GMPR AMPD1 AMPD2 AMPD3 CDA PUDP GMPR2 DCK UPP1 ADA UCKL1 ADK TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 97%5656121 Translesion synthesis by POLI RPA1 RPA2 RPA3 RFC5 RPS27A RFC3 RFC4 RFC2 UBB;UBC REV1 RFC1 MAD2L2 REV3L PCNA UBA52 POLI AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus FOXO1-1 NR4A1 AKT2 AKT3 RPS6KB2 FOXO4 FOXO3 AKT1 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 97%1489509 DAG and IP3 signaling CAMK2G PRKCE ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKCG ITPR1 ITPR2 PRKCD NBEA PRKCA ITPR3 CAMK4 PDE1C PRKAR2B CAMKK1 GRK2 CAMKK2 AHCYL1 KPNA2 PLCG1 PRKX CAMK2B CAMK2D PDE1B PDE1A CAMK2A PRKACA-1 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis ANGPTL3 NR1H3 RXRA FASN NRIP1 RXRB NR1H2 SCD PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%196108 Pregnenolone biosynthesis STARD3NL TSPOAP1 AKR1B1 FDXR STARD3 STARD4 STAR STARD6 TSPO FDX1 CYP11A1 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway S100A8 TLR2 B2M SNAP23 TIRAP HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E STX4 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 TLR6 SEC61A2 PSMB5 PSMB2 SEC61A1 VAMP3 PSMB3 PSMD2 SEC61G PSMD3 SEC61B PSME1 PSMB1 PSMD1 SEC22B PSMB10 CD36 PSMB8 ADRM1 PSMB9 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 MYD88 PSMA4 PSMC3 PSMA1 LY96 PSMC4 PSMC1 CHUK BTK CD14 HMGB1-1 TLR4 IKBKB IKBKG FGB FGA UBA52 FGG CALR-1 VAMP8 PSME2 RPS27A S100A1 UBB;UBC TAP2 TLR1 TAP1 PDIA3 TAPBP S100A9 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME%R-HSA-1855170.3 IPs transport between nucleus and cytosol NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants FLT3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes ATF4 NFYA-1 NFYB DDIT3 NFYC ATF6 CALR-1 HSPA5 HSP90B1 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling SOS1 PSMD12 FCER1A PSMD11 ITPR1 FCER1G PSMD14 ITPR2 PSMD13 ITPR3 PPP3R1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 NFATC2 LAT2 PSMB4 PSMD7 NFATC1 PSMB5 PSMB2 PSMB3 PSMD2 PPP3CA PSMD3 PPP3CB PLCG1 PSMB1 PSMD1 ADRM1 PSMC2-1 MS4A2 PSMA2-1 PSMA5 SEM1 TEC PSMA6 JUN PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 RAC1 CHUK BTK FBXW11 IKBKB IKBKG FOS UBA52 TXK NFATC3 CUL1 VAV3 RPS27A UBB;UBC MAP3K7 VAV1 VAV2 MAP2K4 MAPK9 MAPK8 MAP2K7 MAPK10 UBE2V1 GRAP2 GAB2 PAK1 LCP2 UBE2N TAB3 TAB2 TAB1 ITK PDPK1 TRAF6 SYK PIK3R2 PIK3CB HRAS PIK3R1 FYN NRAS PIK3CA PLCG2 CALM3;CALM1 MAP3K1 CDC34 PRKCQ CARD11 BCL10 RASGRP2 RASGRP1 MALT1 RASGRP4 LYN UBE2D3;UBE2D2 NFKBIA PAK2 UBE2D1 RELA AHCYL1 NFKB1 MAPK1 MAPK3 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade S100A8 TLR2 DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 SOCS1 APP NFKB2 TLR6 CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK BTK FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B S100A1 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 SIGIRR IRAK3 FGB NFKBIA FGA FGG RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 S100A9 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-HSA-1793185.4 Chondroitin sulfate dermatan sulfate metabolism GLB1L2 VCAN GLB1L GLB1 HYAL1 CHST11 HYAL3 CHST12 HYAL4 IDS CHSY3 CHPF2 CHST15 CSPG5 GUSB ARSB CHST13 CHST7 CHSY1-1 CHST14 CHPF CSGALNACT1 DCN CSGALNACT2 DSEL BCAN CHST3 UST DSE IDUA HEXB NCAN HEXA BGN GLB1L3 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-HSA-6811442.2 Intra-Golgi and retrograde Golgi-to-ER traffic COG4 COG3 PLA2G4A COG2 BET1L RAB30 IGF2R RAB36 RAB6B ALPG;ALPP;ALPI-1 GOSR2 AGPAT3 CAPZA3 ACTR10 RAB39A ARFGAP3 COG1 ARFGAP2 DCTN6 DCTN5 DCTN4 ARF4-1 M6PR NSF TMED2-1 RAB1A RAB1B RIC1 RAB6A ACTR1A VAMP4 RAB33B-1 RGP1 RAB18 RAB3GAP2 ARF1 RAB3GAP1 ZW10 TRIP11 GBF1 PAFAH1B1 DYNC1I2 DCTN2 DCTN3 KIF5B KIF5A COPB1 MAN2A2 KIF21A KIF21B KIFAP3 KIF4B;KIF4A KIF16B KIF20A KIF20B KLC1 DYNC1H1 KLC4 KLC3 KLC2 RACGAP1 KIF3B KIF3C DYNC1LI1 KDELR1 DYNC1LI2 KIF18A GCC2 KIF18B SURF4 MAN2A1 KIF12 KIF11 DYNC1I1 KIF15 KIF19 CAPZB KIF13B MAN1A2 KIF1C MAN1C1 MAN1A1 KIF1B KIF3A KIF1A KIF25 KIF23 RAB9A KIF22 KIF6 KIF27 RAB9B KIF9 KIF2A KIFC2 KIFC1 KIF2C KIF2B DCTN1 VAMP3 SEC22B CENPE KIF26A CAPZA1 KIF26B CAPZA2 USP6NL BICD1 SCOC BICD2 SYS1 STX5 GALNT2 GCC1 PAFAH1B3 YKT6 GALNT1 GOLGA1 PAFAH1B2 ARFIP2 RINT1 KDELR2 COPB2 VPS45 COPA ARL1 COPE USE1 RABEPK TMED3 TMED7 NAA30 TMED9 COPZ2 COPZ1 NAA35 NAA38 NAPB TMED10 ARF5 NBAS TMF1 STX18 NAPG STX10 ARFRP1 VPS51 PLA2G6 VPS53 VPS52 BNIP1 VPS54 ARCN1 COPG2 COPG1 GOLGA4 PLIN3 NAPA TGOLN2 STX16 GOSR1 GOLIM4 RHOBTB3 ARFGAP1 CYTH3 CYTH2 GOLGA5 CYTH4 CUX1 STX6 VTI1A CYTH1 COG8 COG7 COG6 KDELR3 COG5 SNAP29 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 97%6791465 Pentose phosphate pathway disease TALDO1 RPIA MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) GUSB SIGNALING BY PDGF%REACTOME%R-HSA-186797.6 Signaling by PDGF SOS1 PDGFB STAT3 COL4A5 THBS2 PDGFRB NCK2 NCK1 STAT6 STAT5A STAT5B SRC PIK3R2 PIK3CB PLCG1 COL9A1 HRAS COL9A3 PIK3R1 COL9A2 PDGFRA RASA1 PLAT COL4A2 COL4A1 NRAS COL4A4 THBS1 COL6A2 PIK3CA COL4A3 COL6A1 PTPN11 COL6A3 COL6A6 COL6A5 GRB7 CRK STAT1 THBS4 THBS3 FURIN PDGFD PTPN12 PLG BCAR1 SPP1 RAPGEF1 CRKL DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734281 Defective HPRT1 disrupts guanine and hypoxanthine salvage HPRT1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 97%5632987 Defective Mismatch Repair Associated With PMS2 PMS2 MLH1 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.5 Serotonin Neurotransmitter Release Cycle UNC13B RAB3A SYT1 SYN3 VAMP2 STX1A CPLX1 SYN2 SYN1 SNAP25 RIMS1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 TSPOAP1 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 97%449836 Other interleukin signaling CSF1R TYK2 VAMP2 STX1A IL16 CASP3 CSF1 SNAP25 IL10RB CSF3 IL34 IFNLR1 SDC1 IFNL2;IFNL3;IFNL1 STX3 STX4 CD4 JAK1 CSF3R PTPRZ1 TXLNA STXBP2 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation PRMT3 METTL21A KIN METTL22 ETFBKMT CAMKMT VCPKMT EEF1A1 FAM86B1;EEF2KMT;FAM86B2 EEF1AKMT2 ETFB VCP-1 EEF1AKMT1 EEF2 CALM3;CALM1 HSPA8 RPS2 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 ADCY9 GNAL DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane PPP2R1A CTNNB1 GSK3B WNT3A CAV1 CSNK1A1 CSNK1G2 WNT1 AMER1 FZD1 PPP2CB;PPP2CA WNT8A WNT8B FZD2 AXIN1 FZD5 PPP2R5B PPP2R5A PPP2R5D PPP2R5C FRAT2 PPP2R1B APC PPP2R5E DVL1 DVL2 LRP5 DVL3 LRP6 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis DHRS7B AGPS GNPAT PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling PDE3B AKT2 LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 97%174824 Lipoprotein metabolism SOAT1 LPL SOAT2 NPC2 NR1H3 APOC1 MTTP APOC4 P4HB APOB MBTPS1 CREB3L3 MBTPS2 VLDLR PRKACB-1 SAR1B NR1H2 MYLIP APOF CUBN A2M ALB AMN PRKACA-1 GPIHBP1 ABCA1 APOA2 APOA1 APOA4 PCSK5 LMF2 APOA5 LMF1 LIPC ANGPTL8 PCSK6 ANGPTL3 FGF21 ANGPTL4 APOC3 CLTC CLTA AP2A1 UBA52 AP2B1 APOC2 AP2A2 LDLRAP1 FURIN AP2S1 LIPG CES3 RPS27A LCAT APOBR UBB;UBC CETP ABCG1 LDLR APOE PCSK9 HDLBP ZDHHC8 LSR LIPA NCEH1 NPC1-1 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-HSA-9032500.2 Activated NTRK2 signals through FYN BDNF GRIN2B SRC RAC1 DOCK3 NTRK2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE RAMAC CDK7 POLR2E POLR2F POLR2H GTF2F1 MNAT1 RNMT GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 RNGTT SUPT5H POLR2J;POLR2J2;POLR2J3 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 RPL27A RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 MTERF3 RPL36AL-1 RPS27L CSNK1D RPS15A LTV1 RRP1 RPS3 FTSJ3 EBNA1BP2 ISG20L2 ERI1 LAS1L NOL12 UBA52 RBM28 RIOK2 RPS2 RIOK1 TEX10 DIS3 SENP3 GNL3 NIP7 NOL9 PES1 RIOK3 WDR18 EXOSC7 WDR12 EXOSC6 BYSL RPL18A EXOSC5 BOP1 FAU EXOSC4 TSR1 RPL12-1 EXOSC9 RPS27A EXOSC8 EXOSC3 EXOSC2 EXOSC1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TPTEP2-CSNK1E;CSNK1E RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 FASTKD2 RPL9 RPL6 RPL7 RPS4X SNU13 RPL35 RPL38 RPS3A RPP30 RPL39 DDX49 DDX47 RPP38 WDR3 FCF1 RPP21 NAT10 RPP25 THUMPD1 RPL21 WDR46 RPL23 WDR43 RPP14 RRP9 RPL22 FBL LOC102724159;PWP2 RPP40 BUD23 UTP14C;UTP14A UTP15 WDR36 UTP11 RPL24 DIMT1 IMP3 WDR75 RPL27 IMP4 RPL26 DDX52 RPL29 UTP18 RPL28 DKC1 NHP2 UTP25 HEATR1 TSR3 NOC4L RPL15-1 NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 RPL3L DCAF13 NOP58 NOP14 UTP6 UTP4 KRR1 PNO1 UTP3 RCL1 TBL3 MPHOSPH10 RPLP1-2 NOL11 NOP10 MTERF4 NSUN4 RPUSD4 RPUSD3 TRUB2 RPL11 RCC1L RPL14 NGRN MRM2 XRN2 RPL13 MRM3 RPL18 RPL17 RPL19 NCL-1 NOP56 RPL10;RPL10L-1 RPL7A RPLP0 TRMT112 PELP1 RPLP2 RPL36-1 RPL35A MTREX TFB1M RPL22L1 RPL37A-1 EXOSC10 C1D MPHOSPH6 NOP2 RPL13A-1 DDX21 RPL5-1 TRMT10C PRORP HSD17B10 RPL23A RPS15 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9970672.2 FXIIa activates plasma kallikrein-kinin system PRCP C1QBP H2AC20 SERPING1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 KNG1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 F12 H2AC4 A2M KLKB1 PLAUR H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 HRG KRT1 H2BC1 H2AC14 H2BC21 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 97%159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus PROC F2 F7 F9 PROS1 F10 GAS6 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism CYP24A1 CYP2R1 GC LDLRAP1 PIAS4 LRP2 CYP27B1 LGMN UBE2I SUMO2 VDR CUBN AGGREPHAGY%REACTOME DATABASE ID RELEASE 97%9646399 Aggrephagy DYNC1I2 HDAC6 DYNC1LI1 DYNC1LI2 UBE2V1 IFT88 HSF1 PRKN CETN1 HSP90AA1 VCP-1 RPS27A CFTR PCNT ARL13B DYNC1I1 UBB;UBC DYNC1H1 PARK7 UBE2N UBA52 SARS-COV INFECTIONS%REACTOME DATABASE ID RELEASE 97%9679506 SARS-CoV Infections RPS14 GJA1 SOS1 RPS17 TLR2 BRMS1 TBK1 RPS16 SNRPD2 RPS19 IFNGR1 SNRPD1 IFNGR2 RPS18 AKT2 AKT3 SNRPD3 RPS11 B2M RPS10 S1PR1 VPS39 RPS13 PTGES3-1 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ST6GAL1 MOGS ATG14 ACE2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 VPS11 ST3GAL4 SNRPE-2 SFN RIPK3 ST3GAL1 REST ST3GAL2 ST3GAL3 VPS16 SRPK2 EDEM2 PARP16 PARP14 PYCARD SRPK1 PARP10 RPS25 RPS27 CASP1 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 NRP1 MAGT1 IFIT1 IKBKE YWHAE IFIT3 JAK1 IFIT2 TOMM70 PARP6 ROCK1 PARP4 PRMT1 RIPK2 SFTPD ANO8 ANO9 HNRNPA1-1 ANO6 TYK2 ANO4 PSMC6 PARP9 IL17RC ANO5 NFE2L2 ANO2 PARP8 YWHAG IL17RA ANO3 ANO1 ATP1B2 EEF1A1 SIKE1 PPIB HSP90AA1 SMN2;SMN1 ATP1B1 CANX TLR8 TLR7 ZDHHC20 TMPRSS2 RPS27L RNF135 RPS15A GPC1 MGAT5 YWHAB RPS3 GPC3 ANO10 GPC2 GPC5 MGAT1 AKT1 UBA52 GPC4 RPS2 NUP214 MGAT2 GPC6 STAT1 KDM1A STAT2 SEC24D-1 YWHAZ MPP5 TJP1 NLRP12 ZDHHC9 STING1 IL17F FAU AGRN VCP-1 RPS27A CRB3 IL17A TUSC3 FXYD4 GEMIN2 FXYD3 UBB;UBC KPNA2 MAP3K7 FXYD1 RPS9 RPS7 FXYD6 RPS8 RPS5 VPS33A PHF21A RPS6 VPS33B RPSA ZCRB1 GOLGA7-1 TUBB4A;TUBB;TUBB8B;TUBB8 TUFM TMEM258 GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 RBX1 GEMIN7 GEMIN8 ISCU RCOR1 IFNAR1 ATP1A4 SNRPB ATP1A3 DDX5 FUT8 BCL2L1 ATP1A2 TKFC IRAK1 ATP1A1 IRAK2 MAN2A1 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 UVRAG CAV1 HMG20B MAVS OSTC ATP1B3-1 STT3A JAK2 FXYD2;FXYD6-FXYD2 UBE2N TAB3 CSNK1A1 TAB2 SP1 STT3B TAB1 HSPG2 GSK3A ST6GALNAC2 HSP90AB1 ITCH PRKCSH MGAT4A-1 RPS4X YWHAQ YWHAH PDPK1 RPS3A DDOST FKBP1A LARP1-1 IRF3 DAD1 CYSLTR1 TRAF3 MBL2-1 TRAF6 SYK IRF7 PIK3C3 MAN1B1 CRBN ST6GALNAC3 ST6GALNAC4 BECN1 FNTA SEC23A DDX20 NOD1 CUL3 NOD2 GANAB SNRPG-2 VHL CNBP-1 SEC24B IFNB1-4 SEC24A GALNT1 PTPN11 COMT MGAT4C VPS41 NUP107 MGAT4B PDCD1 NUP188 VPS45 SEC24C PLCG2 TLR9 CTSV;CTSL NUP210 BST2 NUP93 CHMP4C CHMP4B CHMP4A NUP205 AAAS IL6R NUP160 NUP85 PPIH TPR NUP88 PPIG NUP155 ITGA4 FURIN NUP153 CHMP2B CHMP2A NUP62 RB1 NDC1 SEC13 NUP133 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 NUP42 NCK1 CREBBP NUP43 IL1R1 RAE1 RANBP2 SMAD2;SMAD3 CD79B CD79A ROCK2 NUP35 NUP37 FNTB;CHURC1-FNTB BLNK CHUK BTK DDX58 ISG15 IFIH1 IKBKB IMPDH1 TRIM25 IMPDH2 IKBKG MBD3 AP2A1 AP2B1 KEAP1 AP2A2 GATAD2B AP2S1 GATAD2A ARID4B EP300 SAP30 VAV1 SIGMAR1 ITGB1 SUDS3 NPM1-2 PCBP2 GSK3B KPNB1 UBE2I CHD4 CHD3 ZBP1 NR3C1 SUMO1 PPIA SMAD4 FKBP4 HDAC2 JAK3 HDAC1 PTPN6 MTA1 RBBP4 BRD4 SAP30L RIPK1 SAP18 RUNX1 RBBP7 MTA2 MTA3 RCAN3 NFKBIA RELA NMI SH3KBP1 NFKB1 ARID4A PATJ ZDHHC5 ZDHHC8 TLR1 ZDHHC2 ZDHHC3 RPS15 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 97%3899300 SUMOylation of transcription cofactors TRIM28 MRTFA ZNF131 NRIP1 NPM1-2 NCOR2 SAFB DDX5 UHRF2 ING2 CASP8AP2 BMI1 MBD1 PIAS4 PIAS3 UBE2I RING1 PPARGC1A CREBBP PCGF2 SIN3A RNF2 PIAS1 ZNF350;ZNF432 DAXX CBX8 SUMO1 SUMO3 SUMO2 PHC2 PHC1 HIPK2 CBX4 EP300 CBX2 PHC3 CTBP1 TOPORS PARK7 NCOA1 DDX17 NCOA2 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions PTPN6 PTPN11 SKAP2-2 PTK2B SIRPA;SIRPB1;SIRPG FYB1 CD47 SIRPB1 PTK2 TYROBP DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay EIF4A3 PAN2 PAN3 CNOT10 CNOT4 CNOT6 CNOT7 CNOT11 CNOT1 CNOT2 CNOT3 CNOT8 SKIV2L CNOT9 EIF4A2 EIF4A1 TUT7 TUT4 EIF4E EIF4B LSM5 PAIP1 LSM4 LSM3 LSM2 TNKS1BP1 LSM7 LSM6 CNOT6L DIS3 XRN1 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 WDR61 PABPC1;PABPC3 DDX6 LSM1 PATL1 DCP1A HBS1L EDC3 EIF4G1 EDC4 TTC37 NT5C3B DCP1B DCPS PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2R1B PPP2R1A PFKFB1 PPP2CB;PPP2CA PPP2R5D DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding NTHL1 HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%167161 HIV Transcription Initiation GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SGSH SIGNALING BY FLT3 FUSION PROTEINS%REACTOME%R-HSA-9703465.2 Signaling by FLT3 fusion proteins SOS1 PIK3CA NOX4 MYO18A STAT5A CDKN1A GOLGB1 STAT5B ETV6 GAB2 PIM1 TRIP11 ZMYM2 HRAS PIK3R1 SPTBN1 NRAS POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression ACTB-1 GSK3B CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CHD3 H2BC21 SMARCA5 H2AC20 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CBX3-1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 HDAC1 DDX21 TAF1D BAZ1B MTA1 TAF1B RBBP4 TAF1C KAT2B H2AJ KAT2A TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L DEK SF3B1 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 ERCC6 GATAD2B GATAD2A MYBBP1A TTF1 EP300 H2AC4 EHMT2 H2AC14 GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 97%3828062 GSD 0 (muscle) GYG1 GYS1 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 97%997272 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits GNB3 KCNJ2 GNGT1 KCNJ12;KCNJ18 KCNJ3 GNB5 KCNJ4 GABBR2 GNG10 KCNJ5 GNG2 GABBR1 GNG5 KCNJ6 GNG4 KCNJ10 GNG8 KCNJ9 KCNJ15 KCNJ16 GNG13 GNB2 GNB1 GNB4 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 97%9909396 Circadian clock ARNTL2 NOCT MED1 CSNK2A1;CSNK2A3 PPP1CC PPARGC1A CREBBP ATF2 PSMD12 PSMD11 PSMD14 FBXL3 SREBF1 PSMD13 CLOCK PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 SERPINE1 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 NCOA1 NCOA2 PSMC2-1 PPP1CB NCOA6 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PPP1CA BTRC SIRT1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 NCOR1 FBXW11 CSNK1D UBA52 CUL1 CHD9 EP300 RPS27A UBB;UBC CPT1A TBL1XR1 MEF2C KMT2A CRTC2 CRTC3 RAI1 TPTEP2-CSNK1E;CSNK1E MEF2D HELZ2 RBX1 NPAS2 CDK5 TGS1 RORA RXRA CARM1 PPARA NAMPT RORC RORB SMARCD3 HDAC3 ARNTL CSNK2A2 NRIP1 CRTC1 CIPC TFEB PER2 PER1 DBP NR1D1 BHLHE40 CSNK2B CRY2 CRY1 SIK1;SIK1B RBM4;RBM4B UBE2D1 F7 AVP BHLHE41 KLF15 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis SORD AKR1B1 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 97%5579017 Defective CYP11B1 causes AH4 CYP11B1;CYP11B2 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 97%991365 Activation of GABAB receptors KCNJ2 KCNJ12;KCNJ18 KCNJ3 KCNJ4 GNG10 GABBR2 GNG2 KCNJ5 GNG5 GABBR1 ADCY9 GNG4 KCNJ6 KCNJ10 GNG8 KCNJ9 ADCY4 ADCY3 KCNJ15 KCNJ16 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 GNB2 GNB1 GNAL GNB4 GNB3 GNGT1 GNB5 GNAT3 GNAI1 GNAI3 GNAI2 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation CALM3;CALM1 PDE1C PDE1B PDE1A REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 97%1234158 Regulation of gene expression by Hypoxia-inducible Factor EPO ARNT VEGFA HIF1A CREBBP CITED2 EP300 CA9 EPAS1 HIGD1A C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine ADAR ADARB1 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 97%9936686 Aggregated β-amyloid interacts with fibrinogen FGG FGB FGA PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 97%6811555 PI5P Regulates TP53 Acetylation PIP4P1 TP53 PIP4K2A PIP4K2B PIP4K2C MAP2K6 PIN1 EP300 ING2 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways PDCD6IP LTF EPCAM TLR2 STX1A PDZD3 UPK1A GBP2;GBP3;GBP1 B2M PGK1 CDH1 KPNB1 SH3GL3 SH3GL1 ENO1 CASP5;CASP4 GSK3A HSP90AB1 TRIM27 SNAP25 SRC HBD;HBB GBP7;GBP4 HBA2;HBA1 RAB5A STAM2 GUCY2C MRC1 MET CTNND1 CBLL1 CTSG EPS15 SFPQ-1 CTNNB1 KPNA1 HSP90AA1 EEF2 TXNRD1 NOS2 HGS ATP6V1H CALM3;CALM1 CORO1A RAB7A GBP6 HBEGF STAM DUSP16 UBE2D3;UBE2D2 UBA52 CBL SYT2 SYT1 VAMP2 FURIN VAMP1 SH3GL2 SV2C SV2B SV2A SH3KBP1 CD9 RNF213-2 RPS27A UBB;UBC MAP2K2;MAP2K1 MAPK1 MAP2K4 MAPK3 VPS33B MAP2K7 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 97%4641257 Degradation of AXIN PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 AXIN2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 TNKS TNKS2 RNF146 PSMA7 PSMD8 AXIN1 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 SMURF2 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 97%3560801 Defective B3GAT3 causes JDSSDHD HSPG2 BCAN VCAN GPC6 CSPG5 AGRN SDC1 DCN GPC1 SDC4 GPC3 B3GAT3 SDC2 GPC2 NCAN SDC3 GPC5 BGN GPC4 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 97%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function RDH5 RLBP1 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance DSCC1 CHTF18 BLM CTC1 STN1 TEN1 ACD TINF2 ATRX TERF2 CCNA2-1 POT1 CCNA1 TERF2IP TERF1-1 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLD1 POLR2C POLR2D H2BC21 POLR2G POLR2I DAXX PRIM2 PRIM1 H2AC20 WRAP53 POLA1 POLA2 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 DNA2 RFC5 RFC3 RFC4 RFC2 DKC1 NHP2 H2AJ PPP6C H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TERT POLR2E PPP6R3 LIG1 POLR2F POLR2H POLR2L RFC1 H2BC15;H2BC3;H2BC11;H2BC12 ANKRD28 H2BC5 NOP10 PCNA WRN H2BC1 PIF1 SHQ1 RPA1 RPA2 CDK2 POLD3 POLR2J;POLR2J2;POLR2J3 POLD4 POLD2 RPA3 FEN1 H2AC4 RUVBL2 RUVBL1 RTEL1 H2AC14 FLT3 SIGNALING%REACTOME%R-HSA-9607240.8 FLT3 Signaling ABL2 SOS1 FLT3LG PIK3CA PTPN11 BCL2L11 GRB10 CDKN1B AKT2 GRAP2 AKT3 GAB2 PTPRJ FOXO3 FLT3 SOCS2 AKT1 UBA52 CBL LCK STAT5A STAT5B SLA2 RPS27A SYK SH2B3 UBB;UBC HCK CSK HRAS SLA PIK3R1 FYN SOCS6 NRAS LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 97%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD DLD BCKDHA DBT BCKDHB DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME%R-HSA-9930449.1 Defective cleavage of FV variant at a.a.534 PROC F5 PROS1 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones MBTPS2 ATF4 NFYA-1 NFYB DDIT3 NFYC ATF6 CALR-1 HSPA5 HSP90B1 MBTPS1 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 97%1234174 Cellular response to hypoxia RBX1 CA9 VEGFA CREBBP CITED2 HIF3A PSMD12 PSMD11 PSMD14 PSMD13 EPO PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 HIF1AN PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ARNT HIF1A ADRM1 PSMC2-1 VHL PSMA2-1 PSMA5 CUL2 LIMD1 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 UBE2D3-1 PSMC3 PSMA1 PSMC4 PSMC1 AJUBA UBE2D3;UBE2D2 UBA52 EPAS1 UBE2D1 EGLN1 EGLN3 EGLN2 EP300 RPS27A WTIP HIGD1A UBB;UBC ELOC-1 ELOB DEFECTIVE DHDDS CAUSES RP59%REACTOME DATABASE ID RELEASE 97%4755609 Defective DHDDS causes RP59 NUS1 DHDDS RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 RPL10;RPL10L-1 PSMB7 PSMD6 RPS25 RPS27 PSMB4 PSMD7 RPS29 PSMB5 RPS20 PSMB2 RPS21 PSMB3 PSMD2 RPS24 PSMD3 RPS23 PSMB1 PSMD1 RPL36AL-1 ADRM1 RPL7A PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 UBE2D3-1 PSMC3 PSMA1 PSMC4 RPLP0 PSMC1 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 ANKZF1 KLHDC10 NPLOC4 TCF25 UFD1 NEMF RPL18A FAU RPL12-1 VCP-1 RPS27A UBB;UBC RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RBX1 RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 ZNF598 ASCC2 RPL8 ASCC3 LTN1 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 RPL24 CUL2 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 ABCE1 UBE2D3;UBE2D2 UBE2D1 RPL23A ELOC-1 RPL11 RPL14 RCHY1 ELOB RPL13 RPL18 RPL17 RPL19 RPS15 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 97%9762292 Regulation of CDH11 function CDH8 CTNND1 ADAM19 JUP ANGPTL4 CDH24 CDH11 CTNNB1 ADAM33 CTNNA1 INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 97%913531 Interferon Signaling RPS14 TRIM62 TRIM22;TRIM34;TRIM6-TRIM34 RPS17 RPS16 RPS19 IFNGR1 TRIM46 IFNGR2 TRIM45 RPS18 GBP2;GBP3;GBP1 TRIM35 TRIM38 TRIM31 RPS11 B2M TRIM29 RPS10 TRIM26 RPS13 RPS12 TRIM14 TRIM10 EIF3C;EIF3CL EIF1AY;EIF1AX VCAM1 IRF4 EIF3M EIF3K EIF3L EIF3I EIF3J IRF8 EIF3G SFN EIF3H EIF3E SNCA EIF3F EIF3D EIF3A DNAJC3-1 EIF3B PGGT1B RPS25 RPS27 CASP1 RPS29 RPS20 RPS21 RPS24 RPS23 PLCG1 IFIT1 IFIT3 JAK1 IFIT2 PPP2R1A TYK2 MX1-1 HSPA1L SKP1 RPS27L ILF2 RPS15A RAF1 RPS3 HSPA1A;HSPA1B IFIT5 UBA52 RPS2 NUP214 PRKCD STAT1 STAT2 CUL1 OASL OAS1 FAU OAS3 RPS27A UBB;UBC KPNA2 IRF5 RPS9 HSPA8 RPS7 RPS8 RPS5 RNASEL RPS6 FLNB EIF4G1 RPSA CDK1 PTPN2 EGR1 IFI35 STAT3 RSAD2 IFNAR1 SAMHD1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E IP6K2 MAVS MID1 JAK2 ISG20 UBE2N IRF6 IRF9 RPS4X IRF1 RPS3A IRF2 KPNA4-1 IRF3 TRIM8 TRIM6 TRIM5 TRIM2 IRF7 TRIM3 BECN1 FNTA FCGR1A EIF4A2 EIF4A1 NCAM1 FLNA IFNB1-4 USP18;USP41 PTPN11 NUP107 NUP188 EIF4E2 PDE12 KPNA1 EIF2S2 EIF4E SP100 EIF2S3;EIF2S3B NUP210 DHX9 EIF2S1 BST2 NUP93 NUP205 ABCE1 AAAS NUP160 NUP85 CD44 TPR NUP88 NUP155 FURIN NUP153 IFNG SPHK1 NUP62 MT2A NDC1 SEC13 NUP133 NUP50 POM121;POM121C NUP54 NUP42 NCK1 SOCS1 NUP43 DUS2 RAE1 RANBP2 FAAP24 LOC105377022;FANCB FAAP100 CENPX NUP35 FANCM FANCL FANCA FANCE FANCG FANCF NUP37 TARBP2 PRKRA FNTB;CHURC1-FNTB CHUK UBA7 HSPA5 DDX58 EIF2AK3 ISG15 UBE2L6 IFI44L HERC5 IFIH1 IKBKB TRIM25 GBP6 ARIH1 IKBKG ATF6 FKBP5 SOCS3 PTPN1 TRIM21 PPP2CB;PPP2CA ILF3 PIM1 PPP2R5A KPNA7 KPNA5 KPNA3 PPP2R1B ADAR PPM1B EIF4A3 NPM1-2 MAP2K6 ACTB-1 FANCC KPNB1 NEDD4 UBE2I HSPA2 PIN1 PIAS1 HLA-DPB1-1 HLA-DQB2;HLA-DQB1 SUMO1 HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ACTG1 HLA-DRA GBP7;GBP4 TP53 SMAD7 PSMB8 YBX1 CAMK2B CAMK2D CENPS-CORT;CORT;CENPS CAMK2A CAMK2G PML PTPN6 EIF4G3 EIF4G2 EIF4E3 PTAFR IFITM3;IFITM2;IFITM1 UBE2E1 EIF2AK2 MAPK1 MAPK3 GBP5-1 CIITA IFI30 TRIM68 ICAM1 RPS15 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 97%156902 Peptide chain elongation RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 EEF1A1 EEF2 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%73942 DNA Damage Reversal MGMT ALKBH2 FTO ALKBH5 ALKBH3 ASCC1 ASCC2 ASCC3 SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions RPS14 RPS17 TBK1 RPS16 RPS19 RPS18 NPM1-2 RPS11 BCL2L1 TKFC PCBP2 RPS10 IRAK2 RPS13 RPS12 NLRP3 KPNB1 CAV1 UBE2I MAVS SP1 RIPK3 SFN SMAD2;SMAD3 ITCH RPS4X YWHAQ YWHAH PDPK1 RPS3A PYCARD FKBP1A IRF3 RPS25 CASP1 TRAF3 RPS27 PPIA SMAD4 RPS29 TRAF6 RPS20 RPS21 RPS24 RPS23 YWHAE IFIT1 IKBKE IFIT3 IFIT2 TOMM70 SFTPD HNRNPA1-1 PSMC6 YWHAG EEF1A1 SIKE1 PPIB DDX58 TLR7 BST2 RUNX1 RPS27L IFIH1 RPS15A TRIM25 YWHAB RPS3 RCAN3 UBA52 NFKBIA RPS2 PPIH PPIG YWHAZ MPP5 RELA STING1 NMI FAU EP300 RPS27A KPNA2 UBB;UBC NFKB1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog ULK3 DZIP1 SPOPL P4HB SPOP IHH PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 GRK2 PSMB6 PSMB7 PSMD6 PSMB4 HHIP PSMD7 BOC PSMB5 GAS1 PSMB2 CDON ARRB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 PRKACA-1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CDC73 DHH GPC5 UBA52 CUL1 PRKAR2B VCP-1 RPS27A SYVN1 DERL2 UBB;UBC OS9 EVC2 EFCAB7 OFD1-1 EVC GAS8 IFT172 GLI1 GLI3 GLI2 IFT52 IFT57 DYNC2H1 IFT140 RPGRIP1L KIF7 WDR35 RBX1 GNAS-1 IFT88 ADCY9 SMO PRKAR1B PRKAR1A GPR161 NUMB INTU ADCY4 ADCY3 TULP3 GSK3B ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 KIF3A TTC21B PRKAR2A CSNK1A1 PTCH1 WDR19 IFT122 FUZ ADAM17 ADCY10 ITCH MKS1 SHH SMURF2 ERLEC1 SMURF1 HHAT CUL3 ARRB1 DISP2 SCUBE2 NOTUM CGMP EFFECTS%REACTOME%R-HSA-418457.3 cGMP effects PDE11A PRKG2 ITPR1 PDE10A KCNMB1 KCNMB2 KCNMA1 KCNMB3 KCNMB4 PDE9A PDE5A PDE1B PDE1A PDE2A IRAG1 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection C3-1 TXN CTSG HMOX1 NLRP3 HSP90AB1 RELA MEFV NFKB2 PYCARD NT5E P2RX7 PSTPIP1 C3AR1 IL18 CASP1 IL1A IL1B TXNIP P2RX4 SUGT1 NFKB1 GSDMD ENTPD1 ENTPD5 PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly PSMD9 PSMD4 PSMD5 PAAF1 PSME3 PSME4 PSMD10 PSMB11 POMP PSMA8 PSMF1 PSMG3 PSMG4 PSMG1 PSMG2 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSME1 PSMB1 PSMD1 PSMB10 PSMB8 ADRM1 PSMB9 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 PSME2 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors HSPH1 MASP1 SAA2;SAA1 HPX APOB APOA1 APOL3;APOL4;APOL1;APOL2 AMBP LRP1 JCHAIN HSP90AA1 HMGB1-1 COL1A1 CD5L COL1A2 STAB1 CD163 SSC5D COL3A1 STAB2 FTH1 CALR-1 SCARF1 HBD;HBB HP;HPR HYOU1 HBA2;HBA1 ALB PRDX1 SPARC CD36 COLEC12 APOE MSR1 COLEC11 FTL-1 SCARA5 HSP90B1 COL4A2 MARCO COL4A1 SCGB3A2 S100A9 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome ASH2L WDR5 DPY30 RBBP5 KMT2D S PHASE%REACTOME DATABASE ID RELEASE 97%69242 S Phase ESCO1 ESCO2 AKT2 AKT3 CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 CDC25A PSMD13 CDC25B PRIM2 PRIM1 PSMA7 POLA1 PSMD8 POLA2 PSMB6 DNA2 PSMB7 PSMD6 E2F4-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 TFDP1 PSMD3 TFDP2 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 E2F1 PSMA2-1 ORC1 PSMA5 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 CDC6 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 SKP1 CDCA5 PDS5B PDS5A WAPL PCNA AKT1 UBA52 CUL1 RPA1 PTK6 RPA2 CDK4 CDK2 RPA3 RPS27A UBB;UBC RBX1 CDK7 MNAT1 GSK3B POLD1 CKS1B RFC5 RFC3 RFC4 RFC2 RBL2 CABLES1 WEE1 SMC3 MYC RAD21 STAG1 STAG2 SMC1A RBBP4 MAX CCND1 LIG1 POLE RFC1 LIN54 LIN37 LIN9 LIN52 ANAPC15 ANAPC16 UBE2D1 GINS1 GINS2 ANAPC10 CDC45 ANAPC11 MCM7 MCM8 FZR1 CDC23 POLD3 GINS3 CDC26 GINS4 CDC27 MCM3 POLD4 MCM4 POLD2 ANAPC7 MCM5 E2F5 MCM6 UBE2C MCM2 POLE4 UBE2E1 FEN1 UBE2S CDC16 CCNE2 ANAPC4 POLE2 CCNE1 ANAPC5 RB1 ANAPC1 POLE3 ANAPC2 CCNH ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-HSA-114294.4 Activation, translocation and oligomerization of BAX BAX BID PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%1170546 Prolactin receptor signaling PTPN11 CUL1 STAT5A BTRC RBX1 STAT5B PRL PRLR SKP1 GHR JAK2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-HSA-389357.3 CD28 dependent PI3K Akt signaling PIK3CA MTOR PIK3R3 CD28 PIK3R6 PIK3R5 AKT2 AKT3 CD86 CD80 AKT1 THEM4 RICTOR PRR5 LCK PDPK1 MLST8 TRIB3 MAP3K14 PIK3CD MAPKAP1 PIK3CG PIK3R2 PIK3CB MAP3K8 PIK3R1 FYN POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%156711 Polo-like kinase mediated events CDC25A PKMYT1 CCNB2 CCNB1 RBBP4 MYBL2 EP300 CENPF FOXM1 LIN54 WEE1 LIN37 PLK1 LIN9 LIN52 CDC25C HISTIDINE CATABOLISM%REACTOME%R-HSA-70921.7 Histidine catabolism CARNS1 UROC1 CARNMT1 HNMT FTCD AOC1 HAL AMDHD1 HDC SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants KIT UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases USP8 ATXN7 CDC20 CCNA2-1 CCNA1 IDE USP33 USP5 H2BC18 USP3 FKBP8 SNX3 USP37 USP34 USP47 PSMD12 USP48 USP49 TAF9B PSMD11 USP42 USP22 PSMD14 USP44 CDC25A PSMD13 ADRB2 SMAD2;SMAD3 PTRH2 USP26;USP29 USP16 WDR20 H2AC20 PSMA7 USP24 USP25 PSMD8 USP20 TAF10 USP28 TOMM20 PSMB6 PSMB7 VDAC2-1 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 VDAC3 ARRB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 TOMM70 ADRM1 CCP110 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 USP21 PSMC6 USP4 PSMA4 PSMC3 CYLD PSMA1 PSMC4 PSMC1 BIRC2 BIRC3 KAT2A CFTR DDX58 IFIH1 AXIN2 IKBKG DDB2 H2BC5 UBA52 H2BC1 KEAP1 UFD1 AXIN1 RPS27A RNF123 H2AC4 UBB;UBC MAP3K7 CLSPN VDAC1 SIAH2 USP7 USP2 MDM2-2 SUDS3 MAT2B GATA3 IL33 TADA3 RHOT1 POLB USP30 USP15 MDM4 TAB1 H2BC21 USP10 USP13 AR TNKS TNKS2 RNF146 PTEN SMAD1 SMAD4 SMURF2 TRAF6 TP53 SMAD7 BECN1 HIF1A MYC STAM2 USP18;USP41 USP9X TRRAP TRAF2 FOXO4 USP14 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RIPK1 HGS TADA2B H2BC15;H2BC3;H2BC11;H2BC12 RNF128 NFKBIA OTUB1 ARRB1 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RCE1 H2AC16;H2AC11 TGFBR1-1 MUL1 RUVBL1 WDR48 H2AC14 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME DATABASE ID RELEASE 97%5083632 Defective C1GALT1C1 causes TNPS MUC17 C1GALT1C1 C1GALT1 MUC5B MUC20 MUC21 MUC12 MUC15 MUC3A MUC5AC MUC1 MUC2 MUC7 MUC4 MUC6 MUC13 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%109703 PKB-mediated events PDE3B AKT2 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis ABCG5 ABCD2 APOA1 PEX3 ABCD3 ABCD1 ABCG4 ABCA6 ABCA2 ABCA5 ABCA9 ABCA7 ABCA12 PEX19 ABCG1 ABCA3 ABCG8 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 97%76002 Platelet activation, signaling and aggregation DGKZ PLA2G4A SOS1 GNA13 DGKQ DGKK DGKI PIK3R3 DGKH ABHD6 PIK3R6 PIK3R5 MGLL PDPN MPIG6B GP6 DAGLA STXBP3 STX4 DAGLB FCER1G P2RY1 APP EGF RAP1B HGF AAMP AHSG PRKCE APOA1 LAMP2 RAF1 TUBA4A AKT1 STXBP2 PRKCD RAPGEF3 PRKCA RAPGEF4 YWHAZ VWF MAPK14 PRKCB CYB5R1 TF CLEC1B PDGFB PRKCZ ORM2;ORM1 SELP QSOX1 LCP2 CD63 TBXA2R GNA12 A1BG PDPK1 FN1 IGF1 SERPINA3 CDC42 GNAT3 SYK A2M GNAI3 SERPINF2 FYN HRG FLNA CFD PTPN11 TIMP1 PLCG2 SERPINA1 CALM3;CALM1 ACTN2 CFL1 ARRB1 GNGT1 PLG SOD1 CD9 APBB1IP GAS6 TTN-1 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 CAP1 GNG13 VEGFA GNAQ CD109 GNB2 RAB27B GNB1 PRKCG GNB4 GNB3 ITPR1 ITPR2 GNB5 LCK ITPR3 TLN1 SRC ISLR HABP4 CHID1 PSAP GTPBP2 SYTL4 TAGLN2 NHLRC2 TEX264 ARRB2 SERPINE1 LY6G6F;LY6G6F-LY6G6D ALB ENDOD1 GNAI1 APOH PECAM1 CSK SPARC VTI1B GNAI2 MANF CALU CD36 MAGED2 FERMT3 ECM1 OLA1 PCDH7 CTSW TIMP3 ANXA5 TOR4A SPP2 VEGFB VEGFC VEGFD ADRA2C LHFPL2 PCYOX1L ADRA2A FAM3C ACTN1 LEFTY2;LEFTY1 APLP2 TMX3 RAC1 SELENOP SCG3 PFN1 HSPA5 RARRES2 CYRIB SCCPDH RHOA LGALS3BP WDR1 PLEK PHACTR2 SRGN ITIH4 ITIH3 CLEC3B CRK CDC37L1 PTK2 BRPF3-1 PPBP ITGA2B PTPN1 BCAR1 ABCC4 P2RY12 VAV3 PF4;PF4V1-1 RHOG VAV1 VAV2 RHOB TGFB2 TGFB3 MMRN1 APOOL MPL THPO ADRA2B ACTN4 GP1BA VCL IGF2 LAT PPIA PIK3CG PIK3R2 PIK3CB TRPC7 PIK3R1 ALDOA TRPC6 PRKCH TRPC3 THBS1 PIK3CA PTPN6 TGFB1 SHC1-1 PRKCQ ITGB3 PROS1 RASGRP2 F13A1 RASGRP1 LYN FGB FGA GP1BB F2R FGG F2 F5 F8 SERPING1 CLU KNG1 F2RL2 F2RL3 DGKG GP5 DGKE GP9 DGKD DGKB RAP1A DGKA MAPK1 MAPK3 ABHD12 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 97%4720489 Defective ALG12 causes CDG-1g ALG12 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) CDK6 STAT3 CCNA2-1 CCNA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC21 CDKN2D CDKN2C H2AC20 H2AB2;H2AB3;H2AB1 IGFBP7 H2AZ2;H2AZ1 IL1A JUN CXCL8 MAPK7 CDKN1A CDKN1B H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 FOS H2BC15;H2BC3;H2BC11;H2BC12 CDKN2B H2BC5 UBA52 H2BC1 CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 CDK4 ANAPC11 CDK2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A CDKN2A RPS6KA3 UBE2C UBE2E1 RPS6KA2 H2AC4 UBB;UBC NFKB1 RPS6KA1 IL6 UBE2S CDC16 ANAPC4 MAPK1 ANAPC5 ANAPC1 MAPK3 ANAPC2 EHMT2 EHMT1 H2AC14 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 97%9005895 Pervasive developmental disorders HDAC1 CALM3;CALM1 CAMK4 TBL1XR1 GPS2 NCOR2 NCOR1 SIN3A PRKACA-1 HDAC3 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 97%3249367 STAT6-mediated induction of chemokines TBK1 STAT6 STING1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190372 FGFR3c ligand binding and activation FGF20 FGF23 FGF1 FGF4 FGF16 FGF9 FGF2 GALNT3 FGF18 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 97%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 97%8875513 MET interacts with TNS proteins MET ITGB1 TNS4 TNS3 HGF SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer CBL GAB1 SOS1 PIK3CA HSP90AA1 RPS27A UBB;UBC EGF CDC37 SHC1-1 PLCG1 EGFR HRAS PIK3R1 NRAS UBA52 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 97%1483248 Synthesis of PIPs at the ER membrane MTMR2 PI4KA SACM1L PI4K2B SBF1 PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling CDK1 PTPN2 STAT3 NPM1-2 MAP2K6 FANCC UBE2I MAVS NCK1 HSPA2 DUS2 SNCA SUMO1 DNAJC3-1 FAAP24 LOC105377022;FANCB FAAP100 CENPX TP53 FANCM FANCL FANCA FANCE FANCG FANCF TARBP2 CENPS-CORT;CORT;CENPS PRKRA PPP2R1A HSPA1L CHUK EIF2S2 EIF2S3;EIF2S3B DHX9 EIF2S1 ISG15 UBE2L6 HERC5 ILF2 IKBKB TRIM25 ARIH1 HSPA1A;HSPA1B IKBKG STAT1 PPP2CB;PPP2CA ILF3 PPP2R5A PPP2R1B SPHK1 HSPA8 EIF2AK2 ADAR REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764302 Regulation of CDH19 Expression and Function SOX10 CDH19 ZC3H12A CTNND1 JUP CTNNB1 CTNNA1 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling TGFA PIK3R3 GNG10 BCL2 GNG2 AKT2 GNG5 NOS3 STRN AKT3 GNG4 GNG8 PRKCZ CAV1 GNG13 GNB2 GNB1 ESR1 GNB4 GNB3 ZDHHC21 GNB5 PDPK1 SRC SRF GNAT3 PIK3R2 EGF ESR2 GNAI1 HRAS GNAI3 EGFR GNAI2 PIK3R1 PRMT1 NRAS PIK3CA AREG CDKN1B HSP90AA1 FOXO3 CCND1 MMP7 MMP2 EREG MMP3 BTC CALM3;CALM1 MMP9 S1PR3 ZDHHC7 FOS HBEGF CAV2 IGF1R XPO1 UHMK1 PTK2 EPGN AKT1 GNGT1 ELK1 SPHK1 MAPK1 MAPK3 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 97%1433617 Regulation of signaling by NODAL TDGF1 LEFTY2;LEFTY1 ACVR1B CFC1;CFC1B CER1 DAND5 ACVR1C NODAL ACVR2B ACVR2A DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 97%3359469 Defective MTR causes HMAG MTR-1 MTRR MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing NCBP1 TRA2B PHF5A SNRPD2 PAPOLA SNRPD1 SNRPN SNRPD3 DNAJC8 POLR2A FIP1L1 POLR2B POLR2C POLR2D SRRM2 POLR2G SNRPE-2 POLR2I CSTF3 CSTF2 NCBP2-1 HNRNPH2 RBBP6 PTBP1 PPP1CB HNRNPH1 CPSF4 HNRNPA1-1 CPSF1 CPSF3 HNRNPM PPP1CA RBM5 SF3B1 RBMX UBA52 SRRT RPS27A UBB;UBC SNRPF U2AF1L5;U2AF1 CCAR1 EIF4A3 CASC3 SNRPB THOC1 DDX5 THOC3 PCBP1 THOC2 PCBP2 THOC5 SYMPK CDC40 RBM10 THOC7 THOC6 SRRM1 DDX39A DHX15 DDX39B SARNP ZC3H11A SRSF2 SRSF3 SRSF5 HNRNPC SRSF6 TCERG1 SLU7 SRSF7 SRSF9 RBM8A POLDIP3 SRSF1 U2AF2 FYTTD1-1 DDX46 DHX38 DDX42 SRSF11 RBM17 MAGOH;MAGOHB SRSF4-1 HTATSF1 CHTOP ALYREF UPF3B RNPS1 PPP1R10 CSTF2T CPSF2-1 PRPF40A SMNDC1 U2SURP TUT1 NUDT21 CLP1 SRSF10 SRSF12 YBX1 FUS PAPOLG SNRPG-2 HNRNPA3 SF3B4 SF3B5 SNRPC SF3B2 SNRPA SF3B3 PPP1R8;STX12 SF3B6 SF3A3 SF3A1 SF3A2 POLR2E DHX9 CPSF7 POLR2F GTF2F1 POLR2H GTF2F2 SUGP1 RBM25 PABPN1-1 POLR2L CHERP SNRNP70 PUF60 RBM39 SNRPB2 HNRNPF POLR2J;POLR2J2;POLR2J3 HNRNPA2B1 HNRNPU HNRNPR SNRPA1 PCF11 HNRNPL XRN2 HNRNPK HNRNPD WDR33 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 97%433692 Proton-coupled monocarboxylate transport SLC16A8 SLC16A3 BSG SLC16A1 SLC16A7 EMB PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 97%432142 Platelet sensitization by LDL PLA2G4A PPP2R1A PTPN11 PTPN6 PPP2CB;PPP2CA APOB PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B FGR PPP2R5E PECAM1 MAPK14 LRP8 MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72172 mRNA Splicing TRA2B SNRPD2 SNRPD1 SNRPD3 SNRPE-2 PTBP1 HNRNPH1 HNRNPA1-1 HNRNPM RBMX HSPA8 ZCRB1 SNRPF SNRPB DDX5 HNRNPC TCERG1 GPATCH1 PNN CXorf56-1 ZNF830 SF1 DHX8 PRKRIP1 CWF19L2 SNU13 RNPC3 HTATSF1 WDR70 DHX35 PRPF38A SMU1 NKAP UBL5 PRPF40A GCFC2 PRPF18 SDE2 FAM32A CACTIN SRSF10 SRSF12 PRPF31 PDCD7 RBMX2 FUS SNRPG-2 SNIP1 SNRNP35 IK BCAS2 PRPF4B LENG1 PRPF4 PRPF3 HNRNPA3 SNRNP27 GPKOW SNRNP25 CDC5L SNRPC SNRPA PPP1R8;STX12 ZMAT2 ZMAT5 CCDC12 YJU2 LSM5 LSM4 DHX9 LSM3 LSM2 GTF2F1 LSM8 GTF2F2 LSM7 SUGP1 LSM6 RBM25 NSRP1-1 PPWD1 DDX41 USP39 SART1 SNRNP70 TFIP11 SYF2 LUC7L3 PPIE C9orf78 PPIH WBP4 PPIG ZRSR2-1 RNF113A RBM39 PPIL2 MFAP1 ACIN1 RBM42 BUD13 HNRNPF SNRNP48 HNRNPA2B1 POLR2J;POLR2J2;POLR2J3 FAM50A HNRNPU HNRNPR SNRPA1 HNRNPL HNRNPK HNRNPD ISY1;ISY1-RAB43 NCBP1 PHF5A TXNL4A SNRPN PLRG1 DNAJC8 POLR2A POLR2B POLR2C SNRNP40 POLR2D PPIL3 PPIL4 SRRM2 POLR2G POLR2I CRNKL1 NCBP2-1 HNRNPH2 CWC25 PPIL1-1 CWC27 CWC22 PRPF6 PRPF8 SNW1 CWC15 RBM5 SF3B1 PQBP1 SRRT MTREX SNRNP200 CTNNBL1 PRCC CCAR1 U2AF1L5;U2AF1 EIF4A3 CASC3 PCBP1 PCBP2 CDC40 RBM10 SRRM1 DHX15 DDX39B DHX16 SRSF2 SRSF3 SRSF5 SRSF6 SLU7 SRSF7 SRSF9 WBP11 RBM8A SRSF1 U2AF2 DDX46 DHX38 DDX42 SRSF11 MAGOH;MAGOHB RBM7 RBM17 SRSF4-1 BUD31 ALYREF RBM22 UPF3B RNPS1 DDX23 SMNDC1 U2SURP YBX1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3A3 SF3A1 SF3A2 XAB2 POLR2E SAP18 POLR2F POLR2H POLR2L CHERP PUF60 SNRPB2 AQR PRPF19 EFTUD2 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 97%9913351 Formation of the dystrophin-glycoprotein complex (DGC) DRP2 DMD UTRN LAMC3 SGCE SGCD SGCA SGCB HSPG2 LAMA5 SGCG SNTA1 LAMA3 LAMA2 LAMA4 DAG1 LAMB3 LAMB2 AGRN SGCZ LAMB1 SNTB1 LAMA1 SNTB2 DTNA LAMC2 DTNB LAMC1 SSPN ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis HSD3B1;HSD3B2 SRD5A2 LHB HSD17B12 SRD5A1 SRD5A3 CYP17A1 CGA HSD17B3 POMC DEVELOPMENTAL LINEAGE OF PANCREATIC ENDOCRINE MID PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9981148 Developmental Lineage of Pancreatic Endocrine Mid Progenitor Cells LAMA5 LAMA3 LAMA2 LAMA4 FN1 LAMB3 LAMB2 LAMB1 VTN LAMA1 EGF LAMC3 LAMC2 LAMC1 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702632.2 sunitinib-resistant FLT3 mutants FLT3 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PNKP POLB NEIL1 NEIL2 LIG3 OGG1 XRCC1 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen GP1BA GP5 GP9 ADAMTS13 VWF GP1BB VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate PNPO AOX1 PDXK AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions PTGS1 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 97%5654699 SHC-mediated cascade:FGFR2 FGF20 SOS1 FGF23 FGF2 FGF7 FGF22 FGF3 FGF10 HRAS FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 97%168142 Toll Like Receptor 10 (TLR10) Cascade UBE2V1 MAP2K6 IRAK1 IRAK2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 UBE2N ATF2 TAB3 TAB2 TAB1 APP NFKB2 TRAF6 TLR5 TP53 NOD1 NOD2 RIPK2 ALPK1 NLRX1 AGER S100A12 N4BP1 JUN PPP2R1A USP18;USP41 MYD88 MAPK7 NFKBIB SAA2;SAA1 NKIRAS1 BTRC NKIRAS2 IKBIP IRAK4 ECSIT SKP1 TRAF2 PELI1 CHUK CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 FBXW11 TIFA HMGB1-1 MAP3K1 IKBKB IKBKG FOS UBA52 NFKBIA CUL1 MAPKAPK2 RELA TLR10 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC NFKB1 RPS6KA1 MAP3K7 MAP2K2;MAP2K1 MAP3K8 MEF2A MAP2K3 MAPK1 MAPK14 MAP2K4 MEF2C MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 97%1250342 PI3K events in ERBB4 signaling EREG BTC PIK3CA NRG3 NRG4 PIK3R1 HBEGF NRG1 NRG2 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) ATM TP53BP1 RAD50 PRKDC BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 LIG4 PAXIP1 BABAM1 BABAM2 PIAS4 UIMC1 ABRAXAS1 RNF8 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 BRCC3 H2BC15;H2BC3;H2BC11;H2BC12 MDC1 UBE2N H2BC5 H2BC21 H2BC1 DCLRE1C KAT5 RIF1 POLL NHEJ1 XRCC6 POLM XRCC4 TDP2 HERC2 XRCC5 TDP1 NSD2 MRE11 UBE2V2 NBN BARD1 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy RAB7A DUSP16 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H POLR2L ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 BRF2 TBP BDP1 POU2F1 POLR1C POLR1D CRCP LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 97%9865113 Loss-of-function mutations in DBT cause MSUD2 DLD BCKDHA DBT BCKDHB COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 97%9759218 Cobalamin (Cbl) metabolism MTR-1 MMADHC MTRR MMAA MMAB MMACHC MMUT DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 97%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 97%3108214 SUMOylation of DNA damage response and repair proteins NUP133 BLM NUP50 POM121;POM121C NUP54 BMI1 PIAS4 RING1 NUP42 UBE2I MDC1 NUP43 PARP1 PIAS1 RNF2 HDAC7 RAE1 RANBP2 CBX8 SUMO1 SUMO3 SUMO2 PHC2 PHC1 CBX4 CBX2 PHC3 NUP35 SMC5 CETN2 NUP37 SMC6 SMC3 NSMCE3 RAD21 NSMCE2 NSMCE1 STAG1 EID3 STAG2 SMC1A PML NUP107 NUP188 BRCA1 NSMCE4A TDG SP100 NUP210 RNF168-1 NUP93 RAD52 NUP205 AAAS PCGF2 NUP160 WRN NUP85 NUP214 TPR NUP88 NUP155 XRCC4 RPA1 HERC2 NUP153 XPC CDKN2A NUP62 NDC1 SEC13 INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease DPM1 DPM2 DPM3 PDZD3 DNAJC10 ELAVL2 UPK1A GBP2;GBP3;GBP1 CSNK2A1;CSNK2A3 RPL10A S1PR1 PPP1CC VIM PLCG1 RAB5A EGFR RPL36AL-1 YWHAE PPP1CB PRKACA-1 PRKG2 NEK2 BTRC YWHAG APOA1 SKP1 HSP90AA1 CDC73 LEO1 UBA52 DYNC1I2 PRKAR2B RPL18A RPS27A ELK1 UBB;UBC DYNC1H1 MAP2K4 MAPK8 MAP2K7 TUBB4A;TUBB;TUBB8B;TUBB8 TXN BCL2L1 CDH1 HSPG2 ADAM17 NT5E ACOT2;ACOT1 COMT CTSG RPL15-1 CTSV;CTSL MMP9 ITGA4 FURIN RB1 CCNH H2AC14 TRIM28 MED1 YES1 MED4 MED6 MED7 CCNC-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP SMAD2;SMAD3 H2AC20 EZH2 RPL10;RPL10L-1 MED16 MED17 MED12 MED14 MED13 MED10 MED27 ARF1 MED23 RPLP0 NCOR2 NCOR1 RPLP2 MED24 TAL1 RPL36-1 MED20 GPS2 SF3B1 MBD3 SUZ12 H2BC5 H2BC1 GTF2H1 GTF2H3 VAMP2 GTF2H4 GATAD2B GATAD2A MED31-1 ARID4B EP300 NRBP1 H2AC4 SAP30 TBL1XR1 MED30 ABL1 SUDS3 RPL22L1 CDK8 CDK7 ACTB-1 RPL37A-1 MNAT1 GSK3B KPNB1 PSIP1 CHD4 CHD3 H2BC21 PARP1 TBP EED SMAD4 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 CAMK2B CAMK2D HDAC2 CAMK2A RPL13A-1 HDAC3 SLC25A4 HDAC1 CAMK2G MTA1 RBBP4 SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L PROS1 H2BC15;H2BC3;H2BC11;H2BC12 ERCC3 ERCC2 F2 CLU RPL23A AHCYL1 EIF2AK2 PRKX ENTPD1 TLR1 ENTPD5 LTF TLR2 STX1A CD4 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 WASL IPO5 GRSF1 PSMA7 DNAJC3-1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 IFIT1 IFIT3 ADRM1 IFIT2 VPS36 SNF8 VPS25 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PPP1CA PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 ATP1B2 ATP1B1 GGT1 DPEP2 DPEP1 YWHAB HSPA1A;HSPA1B ELAVL1 XPO1 AKT1 NUP214 GGT5 YWHAZ XRN1 FXYD4 FXYD3 FXYD1 HSPA8 PABPC1;PABPC3 FXYD6 MAPK14 EIF4G1 RBX1 GNAS-1 ADCY9 ATP1A4 ATP1A3 PRKAR1B PRKAR1A ATP1A2 ATP1A1 ADCY4 RPL26L1 ADCY3 ADCY2 RPL4 ADCY1 ADCY8 RPL30 ADCY7 RPL3 ADCY6 RPL32 ADCY5 PRKACB-1 ATP1B3-1 RPL31 FXYD2;FXYD6-FXYD2 RPL34 PRKAR2A ENO1 CSNK1A1 RPL8 RPL9 RPL6 ITCH RPL7 RPL35 RPL38 FKBP1A CD3G RPL39 CYSLTR1 CYSLTR2 GNAT3 SYK FGR RPL21 HCK ADORA2B RPL23 GNAZ GNAI3 RPL22 MED8 FCGR3A;FCGR3B FYN MED9 FCGR1A CUL3 RPL24 RPL27 RPL26 RPL29 C3-1 RPL28 NFKBIB CCNK NUP107 NUP188 CCNT1 GTF2B RCC1 PLCG2 BANF1 TLR9 KPNA1 SUPT16H NUP210 CDK19 LIG1 LIG4 RPL3L GTF2F1 GTF2F2 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 TSG101 NEDD4L RPLP1-2 AAAS GTF2E1 GTF2E2 NUP160 NUP85 CLINT1 TPR NUP88 AP1G1 SUPT4H1-1 XRCC6 AP1S2 NUP155 AP1S1 XRCC4 AP1S3 XRCC5 VTA1 NUP153 AP1B1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 RAB5C CHMP2A NMT2 TAF4B FEN1 ELL ELOC-1 TAF7L NUP62 RPL11 ELOA RPL14 AP1M2 NELFB ELOB RPL13 NELFCD RPL18 AP1M1 NELFA RPL17 CCR5 RPL19 NELFE NDC1 SEC13 PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 POLR2A NUP42 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B ITPR1 POLR2I RAE1 ITPR2 WNT5A RANBP2 ITPR3 RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 FZD7 TCEA1 TAF7 UBAP1 NUP35 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 RPL7A CHUK UBA7 HSPA5 DDX58 TXNRD1 ISG15 RPL35A UBE2L6 HERC5 IFIH1 IKBKB IMPDH1 TRIM25 IMPDH2 ARIH1 IKBKG CLTC CLTA AP2A1 AP2B1 KEAP1 AP2A2 AP2S1 SH3GL2 ATG7 ITGB1 SCAP PIK3R1 CUL5 UBA6 UBA5 JAK3 UBR4 PTPN6 TGFB1 RUNX1 UBA3 UBA1 RELA RNF213-2 NFKB1 IL6 PATJ ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 RPS15 RPS14 GJA1 RPS17 TBK1 RPS16 SNRPD2 RPS19 SNRPD1 RPS18 AKT2 AKT3 SNRPD3 RPS11 B2M RPS10 VPS39 RPS13 PTGES3-1 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ST6GAL1 MOGS ATG14 ACE2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 VPS11 ST3GAL4 SNRPE-2 SFN RIPK3 ST3GAL1 ST3GAL2 ST3GAL3 VPS16 MEFV SRPK2 MLKL EDEM2 NFKB2 PARP16 PYCARD PARP14 P2RX7 SRPK1 PSTPIP1 PARP10 RPS25 RPS27 CASP1 TXNIP RPS29 SDC1 SUGT1 RPS20 RPS21 RPS24 RPS23 NRP1 MAGT1 IKBKE JAK1 TOMM70 PARP6 PTBP1 PARP4 PRMT1 RIPK2 SFTPD HNRNPH1 ANO8 ANO9 HNRNPA1-1 ANO6 MET HNRNPM TYK2 ANO4 CTNND1 PARP9 IL17RC NFE2L2 ANO5 CBLL1 ANO2 EPS15 PARP8 IL17RA ANO3 MYO10 ANO1 EEF1A1 MYO5A SIKE1 MYO1C SMN2;SMN1 EEF2 CANX TLR8 TLR7 ZDHHC20 TMPRSS2 RPS27L RNF135 RPS15A GPC1 MGAT5 RPS3 GPC3 ANO10 GPC2 GPC5 MGAT1 GPC4 RPS2 MGAT2 GPC6 STAT1 KDM1A STAT2 SEC24D-1 MPP5 TJP1 NLRP12 ZDHHC9 STING1 IL17F FAU AGRN VCP-1 CRB3 IL17A TUSC3 GEMIN2 KPNA2 MAP3K7 GSDMD RPS9 RPS7 RPS8 RPS5 VPS33A PHF21A RPS6 VPS33B RPSA ZCRB1 GOLGA7-1 TUFM TMEM258 GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 GEMIN7 GEMIN8 ISCU RCOR1 IFNAR1 SNRPB DDX5 FUT8 TKFC IRAK1 IRAK2 MAN2A1 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 UVRAG HMG20B CAV1 MAVS OSTC STT3A JAK2 UBE2N TAB3 TAB2 STT3B TAB1 GSK3A ST6GALNAC2 HSP90AB1 TRIM27 PRKCSH MGAT4A-1 RPS4X YWHAQ YWHAH PDPK1 RPS3A DDOST LARP1-1 C3AR1 IRF3 DOCK2 IL18 HBD;HBB DAD1 IL1A TRAF3 CDC42 IL1B MBL2-1 TRAF6 P2RX4 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 NOD2 GANAB EIF4A2 SNRPG-2 EIF4A1 VHL GUCY2C CNBP-1 SEC24B IFNB1-4 SEC24A GALNT1 PTPN11 MGAT4C VPS41 MGAT4B VPS45 SEC24C EIF4E NOS2 HGS CALM3;CALM1 ATP6V1H CORO1A PABPN1-1 RAB7A PAK2 IL10 GNGT1 HNRNPF HNRNPA2B1 SNRPA1 GNG10 GNG2 GNG5 GNG4 GNG8 CD163 PLK2 GNG13 RHBDF2 MYH9 GNB2 GNB1 GNB4 GNB3 GNB5 DAXX MAPKAP1 JUN SNW1 SFPQ-1 RAC1 RPTOR EXOC1 ELMO1 ELMO2 CRK DOCK1 HBEGF GBF1 CBL RICTOR NPLOC4 UFD1 FASN U2AF1L5;U2AF1 EIF4A3 NPM1-2 CDC40 SRRM1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 SRSF1 U2AF2 PRR5 DHX38 SRSF11 SRSF4-1 ALYREF MLST8 RNPS1 CBX1 FKBP4 PML MTOR TLR3 LY96 RIPK1 CD14 TLR4 LYN UBE2D3;UBE2D2 NFKBIA H2AC16;H2AC11 MAP2K2;MAP2K1 ARID4A MAPK1 MAPK3 SOS1 BRMS1 IFNGR1 IFNGR2 P4HB H2BC18 REST SLC25A5 SLC25A6 ROCK1 MED19 MED15 MED18 MED11 PPIB MED26 MED29 MED22 MED25 MED21 P4HA1 RBMX P4HA2 P4HA3 SYT1 CYFIP2 CYFIP1 NCKAP1 RPL12-1 WASF1-1 WIPF1 WIPF2 WIPF3 DYNC1LI1 DYNC1LI2 CD28 PGK1 NCKAP1L HNRNPC NOX1 CASP5;CASP4 SP1 ARPC1B ARPC1A SNAP25 KPNA4-1 HYOU1 CPSF2-1 ATL2 CRBN NUDT21 FNTA LY6E FUS NACA BCAS2 C1S HNRNPA0 HNRNPA3 GPKOW CDC5L PDCD1 DHX9 ABI2 BST2 TAOK1 SUGP1 ABI1 PEX19 IGF1R IL6R DNAJB11 PPIE PPIH PPIG SYT2 CD8B;CD8B2 SUN2 SV2C SV2B SV2A CD9 HNRNPU HNRNPR MAP1B WDR61 BTF3 HNRNPL HNRNPK HNRNPD DVL1 WDR33 DVL2 DVL3 GAS6 ISY1;ISY1-RAB43 EPCAM MED13L PHF5A ARPC4 AUP1 ARPC5 IPO7 PAPOLA TXNL4A ARPC2 SNRPN ARPC3 RAB5B NOXA1 NCL-1 PLRG1 DNAJC8 CEBPD CD33-1 FIP1L1 SEC11A NCK1 SEC11C SNRNP40 DNAJA2 ACTR2 PPIL3 PPIL4 PPIL6 SRRM2 IL1R1 COG1 CRNKL1 LCK CSTF3 CSTF2 CD79B ROCK2 CD79A SRC CHMP1A HNRNPH2 TLR6 EMC4 SPCS3 GNAI1 SPCS2 SPCS1 GNAI2 CWC25 PPIL1-1 WASF2 CWC27 WASF3 CWC22 PRPF6 BAIAP2 PRPF8 CPSF4 CPSF1 CPSF3 CWC15 FNTB;CHURC1-FNTB CGAS BLNK BTK RBM5 C4BPA C4BPB CLDN1 LOC110384692;C4A;C4B_2;C4B GBP6 STAM GRPEL1 PTK2 PQBP1 VAMP1 SRRT CALR-1 KPNA7 VAV3 KPNA5 KPNA3 SNRNP200 VAV1 VAV2 CTNNBL1 SIGMAR1 PRCC MERTK KDELR1 CCAR1 WAS TIMD4 NOXO1 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 SYMPK RBM10 PAF1 DYNC1I1 RETREG1 DHX15 DHX16 BCAP31 MYO9B UBE2I SH3GL3 SH3GL1 ZBP1 NR3C1 WBP11 HNRNPUL1 RTN3 DDX46 DDX42 SUMO1 RBM17 DYNLT1 BUD31 RBM22 ACTG1 DDX23 CSTF2T RRBP1 PPIA GBP7;GBP4 SMNDC1 U2SURP HBA2;HBA1 CLP1 CYBA TYRO3 STAM2 MRC1 SF3B4 SF3B5 CSNK2A2 SF3B2 NCKIPSD SF3B3 HMOX1 SF3B6 BRD4 DDX3X-1 SF3A3 SF3A1 SF3A2 XAB2 CSNK2B CPSF7 CLEC5A RPL5-1 VTN BAG2 CHERP RCAN3 EIF4G3 EIF4G2 EIF4E3 DUSP16 CX3CR1 ACTR3-1 CLEC4M;CD209-2 PUF60 SNRPB2 AQR NMI SH3KBP1 PRPF19 MED28-1 PCF11 PACS1 MAPRE3 AXL HDLBP EFTUD2 PDIA3 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses TBK1 SIKE1 PPIB TKFC PCBP2 DDX58 IRAK2 TLR7 BST2 RUNX1 NLRP3 IFIH1 KPNB1 TRIM25 MAVS RCAN3 NFKBIA UBA52 PPIH PPIG RIPK3 ITCH RELA STING1 PYCARD NMI FKBP1A IRF3 CASP1 RPS27A TRAF3 PPIA TRAF6 KPNA2 UBB;UBC NFKB1 IFIT1 IKBKE IFIT3 IFIT2 TOMM70 SFTPD TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.4 Transport of the SLBP Dependant Mature mRNA NCBP1 NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 EIF4E NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NXF1 NUP88 SLBP RAE1 RANBP2 NUP155 NUP153 ALYREF NCBP2-1 NUP35 NUP62 NUP37 NDC1 SEC13 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 97%173599 Formation of the active cofactor, UDP-glucuronate SLC35D1 SLC35D2 UGP2 UGDH UXS1 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 97%9918476 Assembly and Release of Dengue Virus Virions CLINT1 KDELR1 FURIN TSG101 YBX1 LYN GBF1 NCL-1 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 97%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 HSPG2 BCAN VCAN GPC6 B3GALT6 CSPG5 AGRN SDC1 DCN GPC1 SDC4 GPC3 SDC2 GPC2 NCAN SDC3 GPC5 BGN GPC4 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 97%379397 Enzymatic degradation of dopamine by COMT MAOA COMT LRTOMT TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3645790 TGFBR2 Kinase Domain Mutants in Cancer TGFBR1-1 TGFBR2 TGFB1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9612973 Autophagy TBK1 VPS37C ULK1 VPS37D VPS37A VPS37B GABARAP CHMP3 CSNK2A1;CSNK2A3 CHMP6 CHMP7 MAP1LC3B2;MAP1LC3B-1 ATG14 PRKAB2 MVB12B MVB12A PIK3R4 HDAC6 PRKAB1 RRAGA RRAGC RRAGB MTMR3 CETN1 TOMM20 RRAGD TOMM22 VDAC2-1 MAP1LC3A FUNDC1 ATG9A UBAP1 ATG12-1 ARL13B VDAC3 WIPI1 TOMM40 ATG5 MTERF3 TOMM7 TOMM70 MTMR14 PRKAG2 ATM UBE2D3-1 PRKAG1 HSF1 EEF1A1 PRKAG3 HSP90AA1 RPTOR OPTN-1 CFTR LAMP2 PLIN2 UBA52 EPAS1 TSC2 TSC1 DYNC1I2 ATG3 ATG9B ATG10 ATG13 RNASE1 VCP-1 ATG101 RPS27A GFAP PCNT ATG16L2 LAMTOR2 ATG16L1 LAMTOR1 WDR45 UBB;UBC LAMTOR4 MAP1LC3C LAMTOR3 HSPA8 RB1CC1 LAMTOR5 WIPI2 VDAC1 ATG4C DYNC1H1 ATG7 ATG4B ATG4A ATG4D WDR45B AMBRA1 DYNC1LI1 DYNC1LI2 UBE2V1 IFT88 SLC38A9 PRKN DYNC1I1 UVRAG NBR1 RHEB PEX5 USP30 SQSTM1 UBE2N HSP90AB1 MLST8 HBD;HBB MFN1 MFN2 PIK3C3 BECN1 PARK7 PRKAA1 MTOR CSNK2A2 PRKAA2 CSNK2B CHMP4C CHMP4B CHMP4A VPS28 TSG101 UBE2D3;UBE2D2 PLIN3 CHMP2B CHMP2A PINK1 GABARAPL2 DEFENSINS%REACTOME%R-HSA-1461973.3 Defensins TLR2 DEFB129 DEFB128 DEFB127 DEFB106B;DEFB106A DEFB125 DEFB123 DEFB121 ART1 DEFB135 DEFB107A;DEFB107B DEFB132 DEFB130B;DEFB130A DEFB105A;DEFB105B CD4 DEFB103A;DEFB103B DEFB4A;DEFB4B DEFB1 DEFB109B CCR6 CCR2 PRSS3;PRSS2;PRSS1 DEFB131B;DEFB131A DEFB119 DEFA6;DEFA4;DEFA5 DEFB118 DEFB116 DEFB114 DEFB110 TLR1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs NCBP1 SNRPE-2 LSM10 SLBP ZNF473 LSM11 SNRPF SNRPB SNRPD3 NCBP2-1 SNRPG-2 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import TIMM23 PMPCA TIMM13 CHCHD10-1 TIMM50 PITRM1 GRPEL2 TIMM8B DNAJC19 COA4 TIMM8A MTX2 TIMM44 GFER TIMM10B SAMM50 CHCHD7-1 CHCHD3 MTX1 ACO2 HSCB TOMM20 TOMM22 TIMM17A-1 CHCHD2 TOMM40 OTC TIMM22 TOMM7 TIMM10 SLC25A6 LDHD TOMM70 FXN SLC25A12 HSPD1 SLC25A4 ATP5F1A ATP5F1B CS SLC25A13 NDUFB8 IDH3G ATP5MC1 GRPEL1 HSPA9 CYC1 COX19 COQ2 TIMM21 BCS1L COX17 TAZ VDAC1 CHCHD4 CHCHD5 TIMM17B PMPCB CMC2 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport COG4 GJA1 COG3 PLA2G4A COG2 SPTBN2 BET1L RAB30 RAB36 AKT2 HPX AKT3 APOL3;APOL4;APOL1;APOL2 AMBP JCHAIN CTSC GJC1 ALPG;ALPP;ALPI-1 GJC2 GJA3 MAP1LC3B2;MAP1LC3B-1 AGPAT3 GJA10 CAPZA3 GJA5 STXBP3 ACTR10 GJA4 STX4 GJA9 GJA8 GJD2 GJD4 SAR1B GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GOLGA2 SFN DCTN6 DCTN5 DCTN4 APP RAB4A GRIA1 M6PR SYNJ2 NSF SCARB2 SYNJ1 AGFG1 EGF STON1-GTF2A1L KIAA0319 RAB5A EGFR TOR1A TOR1B YWHAE SYT9 SYT8 SNAP91 STON2 PIK3C2A SLC2A8 SLC18A3 SGIP1 EPN2 VAMP4 ACTR1A FCHO1 FCHO2 HSPH1 UBQLN1 REPS2 AREG REPS1 UBQLN2 NECAP2 EPS15 SYT11 YWHAG RAB8A APOA1 HSP90AA1 MYO5A OPTN-1 MYO1C CSNK1D RAB14 UBA52 PAFAH1B1 TSC2 AP4M1 DYNC1I2 TSC1 AP1G2 DCTN2 DNASE2 DCTN3 CLVS2 SEC24D-1 AP4S1 CLVS1 TJP1 KIF5B KIF5A MAN2A2 KIF21A KIF21B KIFAP3 KIF4B;KIF4A KIF16B KIF20A RPS27A KIF20B UBB;UBC KLC1 DYNC1H1 KLC4 COLEC12 KLC3 MSR1 KLC2 COLEC11 RACGAP1 SCARA5 HSP90B1 KIF3B MARCO SCGB3A2 KIF3C MASP1 KIF18A KIF18B ANK1 KIF12 MAN2A1 KIF11 KIF15 COL1A1 INS;INS-IGF2 KIF19 COL1A2 CAPZB KIF13B MAN1A2 KIF1C MAN1C1 KIF1B MAN1A1 KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIF2A KIFC2 YWHAQ KIFC1 YWHAH KIF2C KIF2B SCARF1 HBD;HBB CENPE SEC23A KIF26A CAPZA1 KIF26B CAPZA2 USP6NL BICD1 SEC24B SCOC BICD2 SEC24A SYS1 GALNT2 PAFAH1B3 GCC1 GALNT1 PAFAH1B2 GOLGA1 ARFIP2 RINT1 KDELR2 VPS45 COPB2 SEC24C COPA ARL1 COPE USE1 RABEPK TMED3 TMED7 NAA30 TMED9 COPZ2 HGS COPZ1 CALM3;CALM1 NAA35 RAB7A NAA38 ARF5 NBAS TMF1 STX18 STX10 ARFRP1 VPS51 VPS53 VPS52 BNIP1 VPS54 ARCN1 COPG2 COPG1 RALA-1 VAMP7 DENND5B RABGEF1 RINL TBC1D10C TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TBC1D10A ARFGAP1 TBC1D10B GABARAPL2 TRAPPC2L SYTL1 GAPVD1 RAB32 RAB31 TBC1D20 TBC1D7;TBC1D7-LOC100130357 PREB RAB35 KDELR3 TBC1D24 TBC1D25 DENND6B RIN3 RAB38 ULK1 DENND6A RIN1 TGFA RIN2 GABARAP TBC1D13 TBC1D14 TBC1D17 RAB6B CCZ1;CCZ1B TBC1D15 TBC1D16 TRAPPC3 TRAPPC1 GOSR2 ANKRD27 DENND4B DENND4A TRAPPC4 CD5L TRAPPC5 STAB1 CD163 DENND4C SSC5D HPS1 RAB39A HPS4 MYH9 RAB27A RAB39B RAB27B TRAPPC8 TRAPPC9 CHRM2 MON1A MON1B DENND1C DENND1B ADRB2 GDI1 DENND1A ARF4-1 PRKAB1 GDI2 RAB8B DENND2D DENND2C TRAPPC2;TRAPPC2B DENND2B DENND2A RAB3IL1 RAB33A TRAPPC6A TBC1D2 TMED2-1 RABEP1 TRAPPC6B RAB7B RAB3IP ARF6 PRDX1 RAB1A RABGAP1 RAB1B RAB21 CD36 GGA2 GGA1 ALS2CL GGA3 CHML RIC1 TRAPPC10 RAB6A RAB33B-1 RAB11B RGP1 RAB10 RAB13 RAB18 RAB3GAP2 ARF1 RAB3GAP1 EXOC8 PRKAG1 EXOC7 CHM RAC1 PRKAG3 EXOC4 EXOC3 EREG EXOC6 BTC EXOC5 EXOC2 EXOC1 HBEGF GBF1 RAB11A CBL VAMP2 BIN1 SNX18-1 GJB2 RALGAPA2 GJB1 RALGAPB C2CD5 MIA2 MIA3 AMPH PACSIN2 PACSIN3 PACSIN1 TMEM115 TBC1D1 TBC1D4 GRK3 AGTR1 LRP1 LRP2 TACR1 F5 SLC2A4 COPS7B F8 COPS7A HP;HPR COPS3 COPS6 COPS5 COPS8 S100A9 SNAP29 APOB CD4 PRKAB2 WASL GRK2 PIP5K1C ANK3 IL7R VPS36 SNF8 EPS15L1 VPS25 EPN1 COL4A2 PRKAG2 COL4A1 SBF1 SBF2 CPD COL3A1 YWHAB PICALM COL7A1 AKT1 RAB3A SYT1 YWHAZ COPB1 ITSN2 CD59 CD55 TFRC ITSN1 HSPA8 FNBP1L FNBP1 TF DYNC1LI1 DYNC1LI2 SURF4 MYO6 KIF3A CTSZ ARPC1A HYOU1 CD3G VAMP3 GPS1 LMAN1 STX5 YKT6 SAA2;SAA1 PRKAA2 MCFD2 SERPINA1 PPP6C PPP6R1 PPP6R3 LMAN1L GORASP1 HMGB1-1 SEC22A SEC22C NAPB CHMP4C CHMP4B TMED10 STX17 CHMP4A VPS28 LMAN2L USO1 NAPG TSG101 LMAN2 SEC31B ANKRD28 SEC23IP EPGN CNIH1 AP4E1 ARRB1 CRYZL2P-SEC16B;SEC16B CLINT1 CNIH2 AP1G1 FOLR1 CNIH3 FTH1 SYT2 AP1S2 BET1 AP1S1 LDLRAP1 AP1S3 SH3D19 TPD52 VTA1 AP1B1 AP3B1 AP3S2;AP3S1 VAMP8 GAK CHMP2B DNAJC6 NAPA RAB5C CHMP2A TGOLN2 TFG BLOC1S4 BLOC1S6 SPTB SNX2 BLOC1S1 BLOC1S3 RHOBTB3 SNX9 AP1M2 SNX5 TXNDC5 APOE AP1M1 TBC1D8B FTL-1 SNAPIN DVL2 SORT1 HIP1R SEC13 DTNBP1 TPD52L1 PUM1 VPS37C AP4B1 ARPC4 VPS37D IGF2R ARPC5 VPS37A NECAP1 ANK2 VPS37B GOLGB1 COPS4 YIPF6 ACBD3 ARPC2 ARPC3 CHMP3 RAB5B COPS2 SPTBN4 SPTBN5 CHMP6 CHMP7 CHMP5 AVPR2 SNAP23 VPS4B VPS4A MVB12B ACTR2 MVB12A ARFGAP3 COG1 ARFGAP2 WNT5A SPTA1 HIP1 FZD4 UBAP1 CLTB ARRB2 ALB SPARC DAB2 CLTCL1 ZW10 TRIP11 CFTR SCFD1 SPTBN1 STAM CLTC CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 SPTAN1 CALR-1 CTTN LNPEP KDELR1 RHOQ GCC2 SEC31A DYNC1I1 STAB2 SH3GL3 SH3GL1 TRIP10 RAB9A RAB9B CD3D DCTN1 HBA2;HBA1 SEC22B STAM2 GNS OCRL PLA2G6 ACTR3-1 GOLGA4 PLIN3 SH3KBP1 STX16 GOSR1 GOLIM4 CYTH3 CYTH2 GOLGA5 AVP ALS2 LDLR CYTH4 STX6 CUX1 VTI1A CYTH1 COG8 COG7 COG6 COG5 TGFBR3 EXPRESSION%REACTOME%R-HSA-9839394.2 TGFBR3 expression MYF6 MYCN TCF4 SMAD2;SMAD3 MYF5 TNRC6C MOV10 RXRA TNRC6A-1 AGO4 AGO2 RARA AGO3;AGO1 TNRC6B TCF12 EP300 SMAD4 MYOG HELLS KLF16 TGFBR3 MYOD1 SP1 NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 97%15869 Nucleotide metabolism ENTPD8 ADAL PNP-1 TXN CTPS2 CTPS1 DGUOK GMPS SAMHD1 GMPR AK4-1 CAD GMPR2 AGXT2 NT5C2 PAICS UPB1 UCKL1 DTYMK AK1 RRM1 AK2 GUK1 ADSS1 TYMS AK5 ADSS2 APRT AK6 TYMP NME2 AK7 NT5C AMPD1 AK8 NME3 AK9 NT5E AMPD2 AMPD3 NME1 CDA NME6 NT5M PUDP NT5C1B;NT5C1B-RDH14 UPP1 UMPS RRM2B XDH DPYS ADPRM DCTPP1 HPRT1 ADSL UCK1 ATIC GDA NME4-1 GLRX TXNRD1 DCTD IMPDH1 IMPDH2 CMPK1 ADA ITPA ADK DPYD NUDT5 PFAS PPAT TK2 TK1 DNPH1 DHODH GART NT5C1A RRM2-1 DCK ENTPD1 ENTPD2 ENTPD3 NUDT16 ENTPD4 NUDT15 ENTPD5 NUDT13 ENTPD6 ENTPD7 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 97%9629232 Defective Base Excision Repair Associated with NEIL3 NEIL3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 97%5607761 Dectin-1 mediated noncanonical NF-kB signaling PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK RELB FBXW11 UBA3 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 RELA PSMA7 NFKB2 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A MAP3K14 PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres DSCC1 CHTF18 BLM CTC1 STN1 TEN1 ACD TINF2 TERF2 CCNA2-1 POT1 CCNA1 TERF2IP TERF1-1 POLD1 PRIM2 PRIM1 WRAP53 POLA1 POLA2 DNA2 RFC5 RFC3 RFC4 RFC2 DKC1 NHP2 PPP6C TERT PPP6R3 LIG1 RFC1 ANKRD28 NOP10 PCNA WRN PIF1 SHQ1 RPA1 RPA2 CDK2 POLD3 POLD4 POLD2 RPA3 FEN1 RUVBL2 RUVBL1 RTEL1 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency TPMT CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 97%5690714 CD22 mediated BCR regulation CD22 PTPN6 CD79B CD79A LYN LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 97%9723907 Loss of Function of TP53 in Cancer TP53 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane MIB2 PDCD1 DDOST PDCD1LG2 DAD1 TUSC3 CD274 B3GNT3 OST4 MAGT1 JAK1 RPN2 OSTC STT3A RPN1 STT3B TMEM258 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190373 FGFR1c ligand binding and activation FGF20 FGF23 TGFBR3 GIPC1 ANOS1-1 FGF6 FGF1 FGF4 FGF9 FGF2 DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 97%5609976 Defective GALK1 causes GALCT2 GALK1 SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers SLC24A4 SRI CALM3;CALM1 SLC8A1 SLC8A2 SLC24A5 SLC8A3 SLC24A2 SLC24A3 SLC8B1 SLC24A1 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.5 Telomere C-strand (Lagging Strand) Synthesis DSCC1 CHTF18 BLM CTC1 STN1 TEN1 ACD TINF2 TERF2 POT1 TERF2IP LIG1 TERF1-1 RFC1 POLD1 PCNA WRN PRIM2 RPA1 PRIM1 RPA2 POLA1 POLA2 POLD3 POLD4 DNA2 POLD2 RPA3 RFC5 RFC3 RFC4 FEN1 RFC2 TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 97%110320 Translesion Synthesis by POLH POLH RPA1 SPRTN RPA2 NPLOC4 UFD1 RPA3 VCP-1 RFC5 RPS27A RFC3 RFC4 RFC2 UBB;UBC RFC1 RCHY1 PCNA UBA52 ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%175474 Assembly Of The HIV Virion VPS37C VPS37D VPS37A FURIN VPS37B RPS27A PPIA NMT2 UBAP1 UBB;UBC VPS28 TSG101 MVB12B MVB12A UBA52 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 97%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN2;FCN1 MASP1 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.5 Formation of ATP by chemiosmotic coupling ATP5F1A ATP5F1B ATP5F1C ATP5F1D ATP5MJ ATP5MG ATP5ME ATP5PF ATP5PD ATP5MC2 ATP5MC3 ATP5PB ATP5MC1 DMAC2L ATP5PO TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 APP NFKB2 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK TLR8 TLR7 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 TASL RPS6KA2 IRF5 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 TICAM1 TLR9 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 NFKBIA RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 SLC15A4 INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 97%448706 Interleukin-1 processing NFKB1 GSDMD RELA CTSG NFKB2 IL18 IL1A CASP1 IL1B SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions PRKCA ITGB1 ITGB5 ACTN1 TNC ITGA6 ITGA2 ITGB4 ITGAV TGFB1 FGF2 SDC1 VTN TRAPPC4 ITGB3 CASK SDC4 SDC2 SDC3 THBS1 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620912 Anchoring of the basal body to the plasma membrane CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 RPGRIP1L CEP43 B9D2 MKS1 FBF1 TTBK2 NPHP1 MARK4 RAB3IP AHI1 YWHAE CEP83 CEP57 CEP89 C2CD3 CETN2 CEP164 CCP110 AKAP9-1 TCTN3 TCTN2 MAPRE1-1 TCTN1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 CC2D2A NEK2 IQCB1 CEP290 YWHAG RAB8A KIF24 CDK5RAP2 HSP90AA1 CEP135 TMEM216 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 TMEM67 HAUS2 TUBA4A HAUS1 SEPTIN2 CEP63 SCLT1 RAB11A PAFAH1B1 DYNC1I2 DCTN2 CEP162 SSNA1 B9D1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B CEP97 NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF PTK2B AKT2 NOS3 AKT3 NRP2 NCK2 VEGFA SHC2 NCK1 MAPK13 ITPR1 ITPR2 ITPR3 CDH5 ROCK2 MAPKAP1 PLCG1 NRP1 WASF2 WASF3 ROCK1 BAIAP2 PRKACA-1 AAMP VEGFB CTNND1 VEGFC VEGFD CTNNB1 RAC1 HSP90AA1 RHOA ELMO1 ELMO2 CRK HSPB1 DOCK1 PTK2 AKT1 PXN PRKCD RICTOR PRKCA MAPKAPK2 BCAR1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 VAV1 VAV2 MAPK14 MAPK11 MAPKAPK3 PRKCB PAK1 ITGAV PRKCZ CTNNA1 PAK3 NCKAP1L JUP CAV1 PRKACB-1 PGF FLT1 THEM4 SHB PRR5 PDPK1 MLST8 CDC42 PIK3R2 PIK3CB CYBB HRAS CYBA PIK3R1 RASA1 FYN NRAS PIK3CA MTOR KDR ABI2 CALM3;CALM1 ABI1 ITGB3 PAK2 NCF1 NCF2 NCF4 TRIB3 AHCYL1 SPHK1 FLT4 MAPK12 AXL INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME DATABASE ID RELEASE 97%168277 Influenza Virus Induced Apoptosis SLC25A6 TGFB1 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters SLC4A4 SLC4A8 AHCYL2 SLC4A9 SLC4A10 SLC4A2 SLC4A3 SLC4A5 SLC4A7 SLC4A1 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%2161517 Abacavir transmembrane transport ABCB1 ABCG2 SLC22A2 SLC22A1 SLC22A3 SYNTHESIS OF PS%REACTOME%R-HSA-1483101.3 Synthesis of PS PTDSS2 PTDSS1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation JUN SOS1 GRAP2 PLCG2 PAK1 RAC1 LCP2 MAP3K1 FOS LYN PAK2 VAV3 SYK PLCG1 VAV1 MAPK1 HRAS VAV2 MAP2K4 MAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 NRAS SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 PIAS4 NUP205 NUP42 UBE2I AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 SUMO1 SUMO2 NUP153 NUP35 TOPORS NUP62 NUP37 NDC1 SEC13 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654727 Negative regulation of FGFR2 signaling FGF20 FRS2 PPP2R1A FGF23 PTPN11 FGF2 FGF7 FGF22 FGF3 FGF10 UBA52 CBL PPP2CB;PPP2CA RPS27A UBB;UBC MAPK1 BRAF MAPK3 FGF1 FGF6 MKNK1 FGF4 SPRY2 FGF16 FGF9 FGF18 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-HSA-264870.3 Caspase-mediated cleavage of cytoskeletal proteins VIM ADD1 DBNL CASP3 GSN CASP7 CASP6 GAS2 MAPT SPTAN1 CASP8 PLEC GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 97%3229121 Glycogen storage diseases PPP1R3C GAA RPS27A EPM2A UBB;UBC GBE1 GYG2 GYG1 G6PC1 GYS2 GYS1 G6PC3 SLC37A4 NHLRC1 UBA52 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-9660821.4 ADORA2B mediated anti-inflammatory cytokines production GNG10 GNAS-1 GNG2 GNG5 ADCY9 GNG4 PRKAR1B GNG8 PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 PRKACB-1 GNB2 PRKAR2A GNB1 GNB4 GNB3 GNGT1 GNB5 PRKAR2B GNAT3 IL6 GNAI1 ADORA2B GNAZ GNAI3 PRKX GNAI2 PRKACA-1 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 97%3928663 EPHA-mediated growth cone collapse MYL6 NGEF ROCK2 MYH14 MYH11 YES1 MYH10 RHOA MYL12B FYN ROCK1 MYH9 LYN TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases APAF1 CASP10 ATM TP53 TP63 TP73 PIDD1 NLRC4 CASP6 CASP2 CRADD CASP1 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC CCT5 CCT4 TCP1 CCT6A CCT3 CCT2 CCT8 ACTB-1 CCT7 CCT6B DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 97%4793953 Defective B4GALT1 causes CDG-2d B4GALT1 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex ACTL6A BCL7C BCL7B SMARCA4 DPF2 SMARCC1 SMARCC2 BCL11A ARID1A ACTB-1 SMARCE1 SMARCD1 SMARCB1 BCL11B SMARCD2 PHF10 SS18 BCL7A SMARCD3 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling NOTCH1 HES1 SNW1 MAMLD1 RBPJ KAT2B KAT2A MAML2 EP300 MAML1 RUNX3 MAML3 CREBBP JAG1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 97%917977 Transferrin endocytosis and recycling ATP6V0B MCOLN1 TF ATP6V1B2 ATP6V1E1 ATP6V0C ATP6V1E2 ATP6V1B1 ATP6V1G1 ATP6V1G2 ATP6V1H ATP6V1G3 ATP6V0D1 ATP6V0D2 ATP6V1A ATP6V0A2 ATP6V0A4 ATP6V0E2;ATP6V0E1 ATP6V1D ATP6V1C1 ATP6V1F ATP6V0A1 ATP6V1C2 ATP6AP1 TFRC STEAP3 STEAP4 HFE TCIRG1 TFR2 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 97%9620244 Long-term potentiation DLG2 DLG3 DLG4 CAMK2G GRIA2 SRC GRIA1 NRGN GRIN2A NRG1 GRIN2B CALM3;CALM1 NEFL GRIN1 DLG1 LRRC7 ACTN2 CAMK2B GRIN2C CAMK2D GRIN2D CAMK2A MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 97%9694493 Maturation of protein E UBB;UBC RPS27A UBA52 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 97%4085023 Defective GFPT1 causes CMSTA1 GFPT1 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772572 Early SARS-CoV-2 Infection Events ISCU CHMP3 DDX5 CHMP6 CTSV;CTSL CHMP7 TMPRSS2 MAP1LC3B2;MAP1LC3B-1 CHMP4C CHMP4B GPC1 UVRAG CHMP4A ACE2 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 PIK3R4 GPC4 HSPG2 GPC6 FURIN CHMP2B AGRN VCP-1 CHMP2A SDC1 PIK3C3 NRP1 BECN1 RB1 ZCRB1 VHL METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196854 Metabolism of vitamins and cofactors NMNAT3 MMADHC BST1 NMNAT2 PDSS2 HPDL PDSS1 NMNAT1 COQ8A APOB NOS3 VKORC1L1 ST20-MTHFS;MTHFS PDZD11 LRAT SDC4 SLC25A51;SLC25A52 RBP4 SDC2 SLC5A8 SDC3 RBP2 THTPA NMRK2 MTHFD1 RBP1 NMRK1 MTHFD2 SHMT2 SHMT1 PARP16 RETSAT PARP14 RDH11 PARP10 CD38 SDC1 VKORC1 PARP6 GCH1 PARP4 CYB5R3 AMN GPIHBP1 PRKG2 PARP9 QPRT PARP8 APOA2 APOA1 MCCC2 APOA4 SLC5A6 HSP90AA1 GSTO2 BTD GSTO1 PC PCCA HLCS MCCC1 PCCB ACACB TTR ACACA BCO2 BCO1 GPC1 FOLR2 GPC3 APOC3 MMACHC GPC2 SLC46A1 GPC5 AKT1 GPC4 APOC2 GPC6 MTR-1 UBIAD1 MTRR NADSYN1 NNMT SLC52A3 PANK4 FLAD1 AGRN PANK3 GPHN PANK1 DCAKD COASY PPCDC SLC25A16 NUDT8 VNN1 VNN2 ALDH1L1 PPCS ALDH1L2 FASN ENPP2 ENPP1 LMBRD1 SLC25A42 MTHFD2L ENPP3 AASDHPPT NUDT12 LPL AKR1B15;AKR1B10 CTRB1;CTRB2 CD320 NADK CBLIF SLC22A13 NAXE DHFR2;DHFR HSPG2 ACO1 PTS MMUT NT5E NAXD MTHFD1L CUBN SPR NADK2 ACP5 NAMPT PLB1 CLPS SLC25A19 STARD7 TTPA PNPO SLC19A3 PNLIP LRP1 SLC19A1 SLC19A2 MTHFR TCN2 CALM3;CALM1 TCN1 LRP2 LRP8 IDH1 SLC23A2 COQ9 SLC23A1 COQ7 MOCS2 COQ6 MOCS3 COQ5 COQ3 RFK CYB5A COQ2 LDLRAP1 MMAA ABCD4 MMAB SLC52A1;SLC52A2 GCHFR LRP10 LRP12 SLC2A1 SLC25A32 PRSS3;PRSS2;PRSS1 APOM NAPRT AOX1 LDLR APOE TPK1 RNLS ABCC1 MOCOS PDXK NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%168638 NOD1 2 Signaling Pathway AAMP TNFAIP3 UBE2V1 CYLD BIRC2 CHUK BIRC3 CASP8 MAP2K6 IRAK1 IRAK2 IKBKB IKBKG UBE2N TAB3 CASP5;CASP4 MAPK13 TAB2 TAB1 ITCH CASP2 CASP1 TRAF6 MAP3K7 CASP9 CARD9 MAPK14 MAPK11 NOD1 MAPK12 NOD2 RIPK2 ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 97%165158 Activation of PKB THEM4 PDPK1 AKT2 TRIB3 METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.8 Metabolism of polyamines PSMA6 PSMC5 PSMA3 PSMC6 AGMAT PSMA4 SMS PSMC3 PAOX NQO1 PSMA1 PSMC4 PSMC1 SAT1 SRM PSMD12 PSMD11 PSMD14 AZIN2 PSMD13 PSMA7 ODC1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 OAZ1 PSMD3 PSMB1 PSMD1 AMD1 ADRM1 AZIN1-2 PSMC2-1 PSMA2-1 PSMA5 SEM1 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption TREH GUCA2B CEL GUCA2A LIPF CHIT1 PIR AMY1A;AMY1C;AMY1B;AMY2A;AMY2B SI LCT PNLIP SLC2A2 ALPG;ALPP;ALPI-1 RSC1A1 CLPS SLC2A5 GUCY2C SLC5A1-1 PNLIPRP1 MGAM G2 PHASE%REACTOME%R-HSA-68911.6 G2 Phase CDK2 E2F1 CCNA2-1 CCNA1 E2F3 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins SCP2 PHYH-4 ACOX1 AGPS TYSND1 HSD17B4 ACAA1-1 CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 97%5617833 Cilium Assembly NOTCH1 HDAC6 DLL1 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG RAB8A CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 MYB PAFAH1B1 TNPO1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B KIFAP3 HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 IFT172 TUBB4B CEP97 NEDD1 KIF3B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 KIF3C IFT52 CDK1 IFT57 DYNC2H1 TPTEP2-CSNK1E;CSNK1E IFT140 CEP41 CEP43 RPGRIP1L WDR35 IFT88 SMO KIF3A TTC21B WDR19 IFT122 MKS1 GRHL1 CCT3 CCT2 E2F5 TCP1 CCT8 CCT5 CCT4 ARF4-1 CYS1 LZTFL1 UNC119B ARL6 ARL3 FBF1 MCHR1 TTBK2 E2F4-1 NPHP1 NPHP3 MARK4 RAB11FIP3 ARL13B BBS2 BBS1 TFDP1 RAB3IP BBIP1 AHI1 CEP83 CEP89 C2CD3 GMNN PKD2 PKD1 DYNC2I2 TCTN3 DYNC2I1 TCTN2 TCTN1 TTC26 TRAF3IP1 BBS9 DYNLT2B CNGA2 KIF17 BBS7 HSPB11 CNGA4 DYNC2LI1 BBS5 CC2D2A IFT74 TP73 BBS4 DYNLT5 IQCB1 DYNLT2 IFT80 MKKS EXOC8 IFT20 EXOC7 IFT22 KIF24 IFT43 IFT81 SSTR3 BBS10 TTC30A;TTC30B BBS12 TRIP11 IFT27 RP2 DYNLRB2 TMEM216 EXOC4 DYNLRB1 EXOC3 IFT46 EXOC6 CLUAP1 EXOC5 EXOC2 CNGB1 EXOC1 ASAP1 TMEM67 PDE6D RHO SEPTIN2 GBF1 SCLT1 RAB11A ATAT1 TTC8 CEP162 B9D1 MCIDAS RFX2 RFX3 CCNO GRHL3 GRHL2 INPP5E DEUP1 GMNC FOXJ1 B9D2 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B RETINOID CYCLE DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%2453864 Retinoid cycle disease events OPN1MW3;OPN1MW2;OPN1MW;OPN1LW TTR NAPEPLD LRAT RDH5 STRA6 RDH12 OPN1SW RBP4 RLBP1 ABCA4 RBP1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 97%8955332 Carboxyterminal post-translational modifications of tubulin TTLL11 TUBA1A TTLL9 TUBA3E;TUBA3C-1 TUBA1C TUBB1 TPGS1 TTL TPGS2 SVBP ARPC4-TTLL3;TTLL3 TTLL12-1 TUBB2B;TUBB2A AGTPBP1 LRRC49 NICN1 VASH2 VASH1 AGBL5 TTLL7 AGBL4 TTLL6 TTLL5 TUBB4B TTLL4 AGBL1 AGBL3 TUBB4A;TUBB;TUBB8B;TUBB8 TTLL1 AGBL2 TUBB3;TUBB6 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655302 Signaling by FGFR1 in disease FGF20 CPSF6 FRS2 GAB1 BCR SOS1 FGF23 PIK3CA CEP43 STAT3 FGFR1 TRIM24 GAB2 FGF2 BAG4 ERLIN2 STAT1 MYO18A LRRFIP1 FGFR1OP2 STAT5A STAT5B ZMYM2 PLCG1 HRAS PIK3R1 CUX1 FGF1 FGF6 FGF4 NRAS FGF9 GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis HSD3B1;HSD3B2 CYP17A1 CYP21A2 HSD11B1 CYP11B1;CYP11B2 HSD11B2 SERPINA6 POMC DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B GP1BA GP5 GP9 GGCX F8 F9 F10 GP1BB F11 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 97%5654219 Phospholipase C-mediated cascade: FGFR1 FGF20 FGF23 FGF22 FGF3 FGF10 PLCG1 FGF6 FGF1 FGF4 FGF9 FGF2 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203754 NOSIP mediated eNOS trafficking NOS3 NOSIP REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME DATABASE ID RELEASE 97%9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition PXDN EDIL3 CDH2 SERPINE1 CDH1 SOX2 ZEB1 ITGA2 STT3B GXYLT2 PXN MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events ADD3 MRS2 SLC66A1 ADD2 NIPAL4 PIP-1 ANKH NIPAL1 NIPAL2 NIPAL3 LRRC8C LRRC8D LRRC8A LRRC8B LRRC8E RHAG DMTN MMGT1 NIPA1 CTNS NIPA2 AZGP1 RHCG RHBG TUSC3 ADD1 MAGT1 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription HSPA8 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 97%75876 Synthesis of very long-chain fatty acyl-CoAs ACSBG2 TECR ACSF3 SLC27A3 HACD1 ACSL1 HSD17B3 ACSL6 ACSL5 ELOVL1 TECRL HACD3 ELOVL4 HSD17B12 HACD2 ELOVL2 HACD4 ELOVL3 ELOVL6 ELOVL7 ACSL4 ACSBG1 ELOVL5 ACSL3 TBC RABGAPS%REACTOME DATABASE ID RELEASE 97%8854214 TBC RABGAPs RAB6A RAB33B-1 TBC1D25 RAB11B ULK1 GABARAP TBC1D13 RAB8A TBC1D14 RAB5B TBC1D17 RAB6B OPTN-1 TBC1D15 TBC1D16 MAP1LC3B2;MAP1LC3B-1 RAB7A RAB11A TSC2 TSC1 RAB8B RAB4A RABGEF1 RAB33A RAB5C TBC1D10C TBC1D2 RABEP1 RAB7B TBC1D10A ARF6 TBC1D10B RAB5A RABGAP1 GABARAPL2 SYTL1 GGA2 GGA1 GGA3 TBC1D20 TBC1D7;TBC1D7-LOC100130357 RAB35 TBC1D24 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%1307965 betaKlotho-mediated ligand binding FGF19 FGFR4 KLB NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus MIB2 DLL1 JAG2 WWP2 PSEN1 DLL4 RPS27A PSENEN NCSTN NEURL1 TACC3 PSEN2 UBB;UBC EGF NEURL1B APH1A EGFR APH1B MIB1 NOTCH3 YBX1 JAG1 UBA52 ADAM10 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism NUDT7 HACL1 ACOT4 AMACR ACOXL SLC27A2 PHYH-4 PECR EHHADH-1 HSD17B4 ABCD1 ACOX2 ACOT8 ACOX3 CRAT CROT NUDT19 DECR2 ACBD5-1 SLC25A17 ACBD4 ACAA1-1 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 97%6783984 Glycine degradation AMT DLD OGDH GLDC MRPS36 DLST GCSH-3 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9864848 Complex IV assembly SMIM20 TMEM223 COA5 TACO1 COX6A1 COX6A2 COQ10A-1 SURF1 COX7B COX7A2 COX7C COX6B2 COX6B1 SCO1 COX8A SCO2 COX19 COX8C RAB5IF COX15 TIMM21 COA3 COQ10B COX18 PET117 NDUFA4 COX17 TMEM177 CMC1 COX4I1 COX4I2 HIGD1A COX5B COX5A COX11 COX14 HIGD2A COX7A2L-1 COX20 COX6C DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD CBLIF PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression HERPUD1 CXCL8 DDIT3 EIF2S2 HSPA5 EIF2S3;EIF2S3B CCL13;CCL2 EIF2AK3 EIF2S1 ATF6 KHSRP DIS3 CEBPB ATF4 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 IGFBP1 ATF3 EXOSC9 EXOSC8 DCP2-1 ASNS EXOSC3 EXOSC2 EXOSC1 NFYA-1 CEBPG NFYB NFYC RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 97%9665250 Resistance of ERBB2 KD mutants to AEE788 CDC37 ERBB2 ERBIN HSP90AA1 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 97%4570464 SUMOylation of RNA binding proteins NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NOP58 BMI1 NUP93 NUP205 NUP42 UBE2I RING1 HNRNPC AAAS PCGF2 NUP160 NUP43 NUP85 RNF2 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 CBX8 SUMO1 SUMO2 NUP153 PHC2 PHC1 CBX4 CBX2 PHC3 NUP35 NUP62 HNRNPK NUP37 NDC1 SEC13 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs TNRC6A-1 AGO2 AGO3;AGO1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H POLR2L IPO8 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C H2BC15;H2BC3;H2BC11;H2BC12 POLR2D H2BC5 H2BC21 POLR2G H2BC1 POLR2I H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 POLR2J;POLR2J2;POLR2J3 H2AC4 RAN H2AC14 LYSINE CATABOLISM%REACTOME%R-HSA-71064.8 Lysine catabolism HYKK DLD PIPOX GCDH AADAT ALDH7A1 DLST CRYM PHYKPL SLC25A21 AASS DHTKD1 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME%R-HSA-9014325.5 TICAM1,TRAF6-dependent induction of TAK1 complex TRAF6 UBB;UBC MAP3K7 TLR3 TICAM1 TAB3 TAB2 RPS27A UBA52 TAB1 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 97%140342 Apoptosis induced DNA fragmentation HMGB1-1 H1-0 CASP3 H1-3 KPNB1 H1-2 H1-5 DFFB H1-4 DFFA HMGB2 KPNA1 REPRODUCTION%REACTOME DATABASE ID RELEASE 97%1474165 Reproduction PDPN CXCR4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2AC20 H2AB2;H2AB3;H2AB1 C1orf112 B4GALT1 BRCA2 FIGNL1 ATM TET2 ATR BRCA1 H2AJ FKBP6 POU5F1;POU5F1B TOP3A H2BC5 H2BC1 RPA1 RPA2 CDK4 MLH1 CDK2 RPA3 H2AC4 MRE11 NBN EOMES NANOG;NANOGP8 SOX17 BLM ACD TINF2 SPO11 SYCP1 SYNE2 TERF2 SYNE1 POT1 SUN1 TERF2IP TEX12 TERF1-1 SMC1B MSH4 MSH5 DMC1 SYCP3-2 PSMC3IP RAD51 SYCE2 SYCE1 UBE2I MND1 HSPA2 MLH3 REC8 STAG3 SYCP2-1 H2BC21 RAD51C CATSPER1 KCNU1 BMP4 CATSPER3 CATSPERB CATSPER2 H2AZ2;H2AZ1 CATSPERD CATSPER4 CATSPERG PRDM1 SMC3 SPAM1 RAD21 RBBP8 STAG1 HVCN1 STAG2 SMC1A RAD50 PRDM7;PRDM9 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LMNB1 NANOS3 H2BC15;H2BC3;H2BC11;H2BC12 ADAM2 ZP3;POMZP3 TFAP2C ACR IZUMO1-1 OVGP1 IZUMO3 IZUMO2 IZUMO4 CBFA2T2 ZP1 ZP2 SUN2 ZP4 ADAM21 ADAM20 ADAM30 CD9 H2AC14 CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 97%399956 CRMPs in Sema3A signaling CDK5R1 SEMA3A CRMP1 PLXNA2 PLXNA3 CDK5 FES GSK3B NRP1 FYN PLXNA4 DPYSL4 DPYSL5 DPYSL2 DPYSL3 PLXNA1 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 97%177128 Conjugation of salicylate with glycine GLYATL3 ACSM5 ACSM4 ACSM2A;ACSM2B GLYAT ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG DGAT2 PNPLA2 DGAT1 AWAT2 DGAT2L6 MGLL PNPLA3 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 97%5619060 Defective CP causes aceruloplasminemia (ACERULOP) CP SLC40A1 SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 97%5339716 Signaling by GSK3beta mutants PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency HIBCH ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 97%451326 Activation of kainate receptors upon glutamate binding GNG10 GNG2 GNG5 GNG4 GNG8 CALM3;CALM1 GNG13 GNB2 GNB1 GNB4 GNB3 GNGT1 DLG3 DLG4 GNB5 GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 PLCB3 PLCB1 PLCB2 DLG1 NCALD DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling UBB;UBC ITCH NEDD4 SRC WWP1 RPS27A UBA52 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2474795 Diseases associated with visual transduction OPN1MW3;OPN1MW2;OPN1MW;OPN1LW TTR NAPEPLD LRAT RDH5 STRA6 RDH12 OPN1SW RBP4 RLBP1 ABCA4 RBP1 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) IDS OPSINS%REACTOME DATABASE ID RELEASE 97%419771 Opsins OPN1MW3;OPN1MW2;OPN1MW;OPN1LW OPN3 RGR RRH OPN5 OPN1SW RHO OPN4 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-HSA-453276.4 Regulation of mitotic cell cycle CDK1 BUB1B CDC20 FBXO5 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 AURKB PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 CDC14A ANAPC15 ANAPC16 CUL1 UBE2D1 AURKA ANAPC10 CCNB1 ANAPC11 CDK2 PTTG1;PTTG2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 RB1 ANAPC1 ANAPC2 PLK1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 APP NFKB2 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK TLR7 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 IRF7 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 TICAM1 TLR9 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 NFKBIA RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME%R-HSA-9665246.2 Resistance of ERBB2 KD mutants to neratinib CDC37 ERBB2 ERBIN HSP90AA1 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-HSA-111452.4 Activation and oligomerization of BAK protein BAK1 BID IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%937042 IRAK2 mediated activation of TAK1 complex TRAF6 UBB;UBC MAP3K7 TAB3 TAB2 RPS27A UBA52 IRAK2 TAB1 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity A2M C1QBP KLKB1 PLAUR SERPING1 KNG1 HRG KRT1 F12 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors TP63 PPP1R13B TP73 POU4F1 PPP1R13L AKT2 POU4F2 AKT3 PHF20 ZNF385A TP53 TP53BP2 BANP AKT1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK ARHGEF7 SOS1 GNA13 ARHGEF5 BCL2L11 ARHGEF6 BAD NGEF ABR RASGRF2 PLEKHG2 ARHGEF33 ARHGEF37 ARHGEF38 SOS2 ARHGEF40 FGD1 NGFR FGD2 FGD3 FGD4 ARHGEF26 PLEKHG5 MCF2 RAC1 ECT2 ARHGEF39 KALRN NET1 NGF TIAM1 ARHGEF10L AKAP13 MCF2L ARHGEF11 AATF ARHGEF10 ARHGEF12 MAGED1 VAV3 ARHGEF15 ARHGEF17 TRIO ARHGEF16 ARHGEF19 ARHGEF18 ITSN1 VAV1 VAV2 TIAM2 PREX1 ARHGEF3 ARHGEF4 MAPK8 ARHGEF1 ARHGEF2 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking GJA1 GJC1 GJB2 GJC2 GJB1 GJA3 MYO6 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJD4 GJD3 GJB4 CLTC GJB3 CLTA GJB6 GJB5 GJB7 DNM1 DNM2 CLTB DAB2 CLTCL1 DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696400 Dual Incision in GG-NER RBX1 POLK POLE RFC1 PARP2 POLD1 DDB2 ERCC3 PCNA CHD1L UBA52 PARP1 ERCC5;BIVM-ERCC5 ERCC2 GTF2H1 DDB1 GTF2H3 GTF2H4 RPA1 XPA RPA2 POLD3 POLD4 POLD2 RPA3 RPS27A RFC5 RFC3 RFC4 POLE4 CUL4A UBB;UBC RFC2 ERCC4 POLE2 ERCC1 POLE3 GTF2H2C;GTF2H2C_2;GTF2H2 CUL4B CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69620 Cell Cycle Checkpoints BUB1 CLASP2 BUB1B CDC20 CCNA2-1 CCNA1 PPP1CC BUB3 MAD2L1 PSMD12 PSMD11 SFN PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 RPS27 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 YWHAE ADRM1 PSMC2-1 PSMA2-1 MAPRE1-1 PSMA5 SEM1 PSMA6 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 YWHAG PSMC1 SKP1 FBXW11 YWHAB CKAP5 XPO1 UBA52 PAFAH1B1 DYNC1I2 CUL1 YWHAZ CCNB2 CCNB1 RPS27A CLASP1 UBB;UBC MCM10 DBF4 DYNC1H1 MAPK14 MAPK11 NDE1 PLK1 CDK1 TPTEP2-CSNK1E;CSNK1E DYNC1LI1 DYNC1LI2 KIF18A RBX1 CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 GTSE1 UBE2N CSNK1A1 NUF2 KIF2A YWHAQ NUDC YWHAH KIF2C KIF2B INCENP CENPA CENPE CENPC WEE1 TP53BP1 CENPT NUP107 CENPU CENPF RNF168-1 CENPH CENPI TAOK1 CENPK CENPL CENPM NEK11 CENPO CENPP NUP160 NUP85 CENPQ CLIP1 MAD1L1 BRIP1 CCNE2 CCNE1 SEC13 NUP133 NDC80 RANGAP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SPDL1 MDC1 NUP43 KAT5 CHEK2 CHEK1 RANBP2 HUS1 DNA2 RHNO1 PHF20 NSL1 PCBP4 ATRIP NUP37 BARD1 PLK3 ORC5 COP1 ORC4 ORC6 CDC7 ORC1 ORC3 RAD17 ORC2 ATM CDC6 ATR CDKN1A CDKN1B KNL1 ZW10 BRCA1 BABAM1 DSN1 BABAM2 RMI2 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 RCC2 ZWINT H2BC5 WRN AHCTF1 H2BC1 RPA1 HERC2 RPA2 CDK2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A RPA3 PPP2R5D PPP2R5C RAD1 PPP2R1B PPP2R5E CLSPN MRE11 NBN CDC25C BLM MDM2-2 DYNC1I1 GSK3B PIAS4 B9D2 MDM4 RAD9B H2BC21 SPC24 SPC25 RAD9A ERCC6L PKMYT1 ZWILCH EXO1 PMF1;PMF1-BGLAP TOPBP1 ZNF385A RFC5 RFC3 RFC4 TP53 RFC2 KNTC1 BIRC5 SGO1 UBE2V2 SGO2 AURKB CENPS-CORT;CORT;CENPS RBBP8 RAD50 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2BC15;H2BC3;H2BC11;H2BC12 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CDC45 ANAPC11 MCM7 NSD2 MCM8 CDC23 CDC26 CDC27 MCM3 MCM4 ANAPC7 MCM5 CDKN2A MCM6 UBE2C MCM2 UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 PROC F5 PROS1 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%73864 RNA Polymerase I Transcription RRN3 CDK7 MNAT1 CAVIN1 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CHD3 H2BC21 UBTF H2AC20 PHF6 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 CBX3-1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 HDAC2 HDAC1 TAF1D MTA1 TAF1B RBBP4 TAF1C KAT2B H2AJ KAT2A TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 ERCC3 MBD2 H2BC1 ERCC2 GTF2H1 GTF2H3 ERCC6 GTF2H4 GATAD2B GATAD2A TTF1 H2AC4 MAPK3 CCNH EHMT2 H2AC14 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 97%390696 Adrenoceptors ADRA1A ADRB1 ADRB2 ADRA2C ADRB3 ADRA2A ADRA2B ADRA1D ADRA1B FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%R-HSA-2644605.3 FBXW7 Mutants and NOTCH1 in Cancer NOTCH1 CUL1 RBX1 SKP1 CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway CAMK2G ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKCG PRKCD NBEA PRKCA CAMK4 PDE1C PRKAR2B CAMKK1 GRK2 CAMKK2 KPNA2 PRKX CAMK2B CAMK2D PDE1B PDE1A CAMK2A PRKACA-1 PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion HGS UBB;UBC CORO1A RAB7A RAB5A VPS33B RPS27A UBA52 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811434 COPI-dependent Golgi-to-ER retrograde traffic KDELR1 KIF18A KIF18B SURF4 KIF12 KIF11 KIF15 KIF19 KIF13B KIF1C KIF1B KIF1A KIF3A KIF25 KIF23 KIF22 ARFGAP3 KIF6 KIF27 ARFGAP2 KIF9 ARF4-1 KIF2A KIFC2 KIFC1 KIF2C KIF2B NSF TMED2-1 RAB1A SEC22B RAB1B CENPE KIF26A KIF26B RINT1 KDELR2 ARF1 COPB2 COPA ZW10 COPE USE1 TMED3 TMED7 TMED9 COPZ2 COPZ1 NAPB ARF5 TMED10 NBAS STX18 NAPG GBF1 BNIP1 ARCN1 COPG2 COPG1 KIF5B KIF5A COPB1 KIF21A KIF21B KIFAP3 KIF4B;KIF4A KIF16B KIF20A KIF20B NAPA ARFGAP1 KLC1 KLC4 KLC3 KLC2 RACGAP1 KIF3B KDELR3 KIF3C DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 97%1266738 Developmental Biology MARK3 CLASP2 LIMK2 LIMK1 CSNK2A1;CSNK2A3 RPL10A HDAC11 BMI1 ETS1 TNF RARS1 YY1 IL4R EBF1 KLF13 RING1 IL13 MAF IRF4 CCL3L1;CCL3L3;CCL3;CCL18 HDAC5 SATB1 HDAC9 RNF2 HDAC6 CNTN1 HDAC7 TBX21 STAT6 CBX8 STAT5A STAT5B CBX6 PHC2 PHC1 POU2F1 CBX4 CBX2 NFATC2 NFATC1 POU2F2 PHC3 BATF IL4 EGF IL5 ERBB2 PLCG1 EGFR RPL36AL-1 YWHAE PRKACA-1 YWHAG HSP90AA1 TCF7 TERT CYP51A1 AJUBA UBA52 CSF1 CCNB1 ST8SIA2 RPL18A RPS27A RPS6KA3 RPS6KA5 CLASP1 UBB;UBC RPS6KA2 RPS6KA1 MEF2A MEF2C PLK1 SPI1 HELZ2 STAT3 BCL2 TYR CAPNS1 GRIN2B CDH1 INS;INS-IGF2 HEY1 HEY2 CAPN1 ADAM10 PSEN1 NCSTN COL9A1 COL9A3 COL9A2 LAMC2 LAMC1 RPL15-1 FOXO4 FOXO3 MMP2 MMP9 LAMA5 LAMA3 FURIN HAND2 ITGA5 YAP1-1 LAMB3 LAMB1 TBX5 SMARCB1 DCT THRAP3 TRIM33 H2AC14 DPF1 DPF2 DPF3 FAM120B TGFA MED1 SMARCC1 SMARCC2 WWTR1 YES1 MED4 MED6 MED7 HNF4G PAXIP1 FOXO1-1 CCNC-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A PPARGC1B CREBBP RAB27A IHH CCND3 SS18L1 SMARCA2 SMAD2;SMAD3 SMARCA4 H2AC20 LDB1 H2AB2;H2AB3;H2AB1 EZH2 RPL10;RPL10L-1 ASH2L MED16 MED17 SERPINE1 MED12 MED14 MED13 MED10 SOX1 CD36 ZIC2 OTX2 NCOA1 POU3F1 NKX2-5 NCOA2 SS18 NCOA6 NCOA3 ACTL6A RARG MED27 SIRT1 MED23 TEAD1 RPLP0 TEAD2 NCOR2 KAT2B H2AJ TEAD4 KAT2A TCF12 NCOR1 RPLP2 MED24 TAL1 RPL36-1 RARB TET3 WNT10B MED20 ANGPTL4 ELOVL3 MC4R PLIN1 HINT1 EDNRB MBD3 TNFSF11 FOXD3 SUZ12 H2BC5 EDN1 PCGF2 EDN3 TFE3 H2BC1 MITF SOX10 POU3F2 MC3R TFEC GATAD2B ALX3 ITGA2B GATAD2A TBX3 FABP4 MC1R KARS1 MC5R UCP1 ID1 MED31-1 EP300 MEN1 H2AC4 ADIPOQ TBL1XR1 KMT2D PLXNA4 KMT2A KMT2C LPL MED30 ABL1 RPL22L1 ZNF521 CDK8 CDK5 ACTB-1 RPL37A-1 GSK3B KLF4 DPY30 CHD4 SOX9 CHD3 PAGR1 BCL7A SIN3A H2BC21 BCL7C BCL7B WDR5 KDM6A EED H2AZ2;H2AZ1 ARID1A ARID1B SMAD1 SMAD4 PIK3CD SMARCD1 CEBPA SMARCD2 HDAC2 RPL13A-1 SMARCD3 HDAC3 UHRF1 HDAC1 HES1 MTA1 RBBP4 RBBP5 TFEB H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L SMARCE1 ITGB3 DEK H2BC15;H2BC3;H2BC11;H2BC12 IARS1 DMRT1 SRY ADIRF SLC2A4 ZNF638 ZNF467 KLF5 RPL23A GPR143 SEMA5A STX1A PIK3R3 RPL27A MESP2 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 WASL LEF1 RBPJ DLL1 PSMA7 DLL3 PSMD8 LFNG PSMB6 PSMB7 PSMD6 LEP PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 CDON PSMD2 PSMD3 ANK3 PSMB1 PSMD1 HES7 EPHA4 ADRM1 MSGN1 TBX6 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 ATP6V1E1 RIPPLY2 PSMC3 PSMA1 ATP6V1G1 PSMC4 PSMC1 CTNNB1 ATP6V0D1 YWHAB ATP6V1A XPO1 KRT1 AKT1 PRKCA YWHAZ ATP6V1C1 CHD9 HSPA8 PABPC1;PABPC3 MAPK14 DARS1 MAPK11 ZEB2 ZEB1 EIF4G1 ATP6V0B MEF2D ATP6V1B2 ATP6V0C RBX1 TREM2 TYROBP NUMB RPL26L1 RPL4 RPL30 RPL3 RPL32 PRKACB-1 RPL31 RPL34 PRKAR2A RPL8 RPL9 RPL6 ATP6V0E2;ATP6V0E1 RPL7 MYRIP RPL35 RPL38 DAG1 RPL39 RPL21 RPL23 RPL22 HRAS MED8 FYN MED9 RASA1 CSF3R RPL24 NRAS RPL27 RPL26 RPL29 RPL28 CDK19 LIG1 RPL3L RPLP1-2 DPYSL4 DPYSL5 DPYSL2 DPYSL3 PLXNC1 SEMA6A SEMA6D ITGA1 SEMA7A SEMA3A CRMP1 SEMA3E RRAS PLXNA2 PLXNA3 POLR2J;POLR2J2;POLR2J3 SEMA4A CD72 SEMA4D PTPRC FES PLXNB3 NTN3 CDH4 CDH2 BNIP2 ASAH1 ELOC-1 CTNNA2 NEO1 RPL11 RPL14 SPAG9 MEF2B;BORCS8-MEF2B MAPK12 ELOB RPL13 RPL18 CDH15 RPL17 CACNB1 RPL19 CACNB4 NCBP1 CXCR4 POLR2A IRS2 CACNB2 POLR2B PRL CACNB3 POLR2C POLR2D POLR2G POLR2I WNT1 NCBP2-1 CLTB PPP3CB CLTCL1 RPL7A NCAN TYRP1 RPL35A LGI1 LGI4 LGI3 LGI2 ADAM11 ADAM22 CACNG8 ADAM23 CACNG2 CLTC CACNG3 CLTA CACNG4 AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 PTGDS FOXF1 SIAH2 SIAH1 ITGB1 ROBO2 RET FOXC2 FOXC1 SIX1 GATA3 PCDH19 HOXD11 FGF2 HOXC11 WFDC2 HOXA11 PLAC8 SALL1 WNT11 MECOM CIDEA SIX2 HNF4A SLIT2 HOXA6 WNT4 IRX1 IRX2 EMX2 JAG1 CTCF QARS1 EYA1 OSR1 WNT9B GFRA1 HNF1B NPNT PAX2 POU3F3 GREM1 BMP4 PAX8 VASP GDNF WT1 ENAH LHX1 ID4 ITGA8 HOXB4 PIK3R2 PIK3CB PIK3R1 MYC CUL2 AKAP5 FRS2 PIK3CA TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 SCD5 AGO3;AGO1 RANBP9 TNRC6B TGFB1 CCND1 EZR CBFB RUNX3 RUNX1 HOXA3 HOXA1 PKNOX1 HOXA4 PIAS2 TFAP2A HOXB3 HOXB2 TFAP2C HOXB1 HOXD1 MEIS1 TFAP2E;TFAP2B MAFB RDX HOXD4 HOXD3 ZNF335 CEBPB BIRC7 RELA NAB1 NAB2 TCF7L2 SLC2A2 CDKN2A EGR2 NFKB1 RPS15 HOXC4 RPS14 RPS17 SPTBN2 RPS16 MARS1 RPS19 RPS18 AKT2 AKT3 RPS11 RPS10 RPS13 RPS12 SDC2 POMC CDC25B SRPK1 PRDM14 RPS25 RPS27 LIN28A ZIC3 RPS29 ZSCAN10 RPS20 TDGF1 RPS21 RPS24 DLG1 RPS23 NRP1 GAB1 MET AREG MYO10 MYO5A CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 GXYLT2 SPRR3 SYTL2 FGF7 CSTA KLK5 PMEL EDIL3 PCSK6 EVPL MLANA RPS27L TBX2 KLK8 FGF10 PPL MLPH LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 RPS15A TCF7L1 GPC1 TGM1 WNT3A CASP14 DLX5 LIPJ POU5F1;POU5F1B RPS3 PAX3 SPRR1A;SPRR1B LIPN SOX2 LIPM PAX7 ZIC1 PRSS8 LIPK MYB NELL2 MSX1 TGM5 SLIT3 ST14 RPS2 CDSN SPINK6 SPINK5 KLK13 KLK14 KAZN CELA2B;CELA2A LCE6A PKP2 PKP1 LORICRIN DSG3 KIF4B;KIF4A FAU AGRN PKP3 SPINK9 FGF8 DSG4 DSC1 ZFPM2 IVL GATA6 DSC2 DSC3 GATA4 RPS9 GATA2 RPS7 RPS8 RPS5 RPS6 RPSA CNTN6 CHL1 ITGA2 ITGA10 ANK1 UNC5A DCC UNC5B UNC5C UNC5D NTN1 STT3B HSP90AB1 RPS4X YWHAH RPS3A CDC42 ST8SIA4 EIF4A2 BTG4 EIF4A1 TUT7 TUT4 DUXB DIS3L2 STPG4 DICER1 PTPN11 METTL23 DPPA4 DPPA3 DPPA2 ZFP36L2 LEUTX HIRA DUX4;DUXA EIF4E EIF4B PAIP1 NPM2 AICDA H1-8 TPRX1;RAX2 ATP6V1H ZSCAN4 PABPN1-1 PITPNA RPS6KA6 CFL1 STAT4 PAK2 IL12RB2 DLG3 MSN IFNG CACNA1H GRIN1 ONECUT1 NEUROD1 NKX6-1 NKX2-2 MYH9 PDX1 PAX6 HNF1A MAFA RFX6 HIF3A IAPP INSM1 KAT5 PTF1A FOXA3 NEUROG3 FOXA2 MAML2 MAML1 TFDP1 TFDP2 MAML3 NOTCH2 E2F1 JUN SNW1 MAMLD1 MAPK7 CDKN1A LEFTY2;LEFTY1 ARHGAP35 BRCA1 RAC1 RHOA TNKS1BP1 DOK1 CNOT6L FOS DOCK1 CFC1;CFC1B DAND5 NODAL EPAS1 PXN PERP CDK4 CDK2 CER1 FOXH1 PSEN2 APH1A APH1B DRAP1 SOX17 MYF6 TCF4 MYF5 FLRT3 EIF4A3 CASC3 PBX1 ITGAV MAP2K6 AMH CNOT10 PSENEN MYOG CNOT4 CNOT6 NOG MAG CNOT7 MYOD1 CNOT11 CNOT1 ACVR1B CNOT2 CNOT3 ACVR1C RBM8A ACVR2B ACVR2A CNOT8 CNOT9 MAGOH;MAGOHB UPF3B RNPS1 TRPM1 NR2F2 TRPC7 TRPC5 TRPC6 FOXA1 TRPC3 TRPC4 TRPC1 CXCL12 HDAC10 USF1 DOK2 SHC1-1 PRDM16 PRKCQ LYN TIAM1 CDK5R1 GCK KRTAP27-1 KRTAP16-1 KRT81;KRT83-1 MCM5 FLI1 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 MCM2 KRTAP4-3 MBP MAP2K2;MAP2K1 KRTAP13-4;KRTAP23-1;KRTAP13-3-1 ZNF423 ADGRV1 KRT3;KRT76 MAPK1 KRTAP29-1 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 MAPK3 KRTAP8-1 KRTAP9-4;KRTAP9-3;KRTAP9-8;KRTAP9-7;KRTAP9-6;KRTAP9-2;KRTAP9-9-1 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 MPZ FGF4 ADGRG6 HMGCR FGF9 KRTAP10-8 KRT16;KRT14 KRT6B;KRT6C;KRT6A SOS1 KRTAP1-5;KRTAP1-3;KRTAP1-1;KRTAP1-4 KRTAP26-1 GRB10 KRTAP3-1 KRT10-2 KRTAP3-2;KRTAP3-3-1 KRTAP19-5 MSI1 CEBPE HOXA2 GFI1 ISL1 KRT4 KRT2 COL4A5 GSPT2 KRT8 GSPT1 EBF2 LHX3 KRT7 LHX2 KRT5 LHX4 KRT9 LHX9 KRTAP13-1;KRTAP13-2 GDF1 KDM5A USP33 KRT24 ROBO1 KDM5B UPF2 KRT23 ETF1 KRT20 ZSWIM8 KRT33A;KRT33B;KRT31-2 KDM6B SLIT1 KRT28 KRT27 KRT26 PRX KRT25 KRT32 HDAC8 KRT39 KRT36 KRT13 KRT12 KRT19 KRT18 LARS1 KRT17 KRT15 KRTAP24-1 KRT71 KRT79 KRT78 KRT77 KRT75 KRT74 KRT73 KRT72 KRT40 KRTAP11-1 KRT82 KRT80 PIP5K1C KRT85 KRT84 NOTO PMP22 ROCK1 MED19 COL4A2 COL4A1 MED15 COL4A4 MED18 COL6A2 PXDN MED11 COL4A3 COL6A1 DSP COL6A3 COL6A6 COL6A5 MED26 MED29 MED22 MED25 DSG1 MED21 PKP4 EPHA2 KIT MESP1 TBX20 SMYD1 TBX1 MYOCD HAND1 RPL12-1 TRIO ITSN1 EOMES TBXT NANOG;NANOGP8 GSC TBPL2 MIXL1 TPST2 MYL6 NGEF SNAI1 SNAI2 GMPR GAB2 SALL4 JUP SDCBP ARPC1B ARPC1A FN1 SHH CACNA1G CACNA1I NRTN NCAM1 CACNA1S PRNP PSPN GFRA2 GFRA4 ARTN CNTN2 FARP2 IL6R PLXND1 ALCAM SCN11A SCN10A AGAP2 L1CAM LYPLA2 DSCAML1 SHC3 HNRNPU RAP1GAP DAB1 PTPRA CNTNAP1 SPTB ITGA9 NTN4 ABLIM1 ABLIM2 ABLIM3 NFASC EPHB6 PCK1 RPS6KA4 EPHB2 EPHB1 EPHB4 SCN1B EPHB3 PLXNA1 SCN1A ABL2 EPHA5 SRGAP3 EPHA7 MED13L SRGAP2 EPHA6 SRGAP1 ARPC4 EPHA8 AIMP1 ARPC5 ANK2 SHTN1 KCNQ2 KCNQ3 AIMP2 ARPC2 EPHA1 ARPC3 EPHA3 EPRS1 SPTBN4 SPTBN5 EPHA10 PLXNB1 MYL12A SCN3B SCN3A CD24 SCN2A SCN2B NRP2 CEBPD VLDLR CAP1 NCK2 GFRA3 RGMB NCK1 RGMA RELN CAP2 ACTR2 SCN9A NRCAM DSCAM DOK4 DOK5 SCN8A DOK6 EFNA5 DSG2 EFNA4 SREBF2 SPTA1 EVL TLN1 EFNB2 PFN2-1 EEF1E1 EFNB1 SOS2 EFNB3 ROCK2 EFNA1 SRC EFNA3 SRF EFNA2 HJV SCN5A GAP43 DCX SCN4A SCN4B SHANK3 LAMA1 SCN7A PDLIM7 DRP2 FGFR1 PFN1 GRB7 UTRN KALRN MYL12B BMP7 SPTBN1 DHH LAMC3 PTK2 LAMA2 SPTAN1 LAMA4 GIT1 CACNA1D LAMB2 VAV3 CACNA1C RHOC VAV2 RHOB ARHGEF7 PAK1 CTNNA1 PAK3 PAK5 PAK4 HDAC4 MYO9B UBE2I TGS1 NR5A1 RXRA SUMO1 BUB1B-PAK6;PAK6 RARA BCL2A1 CARM1 ARHGAP39 PPARG PPARA ACTG1 TP53 ARHGEF28 CSNK2A2 MYH14 MYH11 MYH10 CSNK2B RPL5-1 VTN DIAPH1 DLG4 ACTR3-1 RND1 ARHGEF11 ARHGEF12 SH3KBP1 MED28-1 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease SOS1 STAT1 PIK3CA LCK STAT5A STAT3 PIK3R3 STAT5B YES1 PIK3R2 HRAS PIK3R1 FYN JAK2 LYN KIT NRAS FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190375 FGFR2c ligand binding and activation FGF20 FGF23 FGF6 FGF1 FGF4 FGF16 FGF9 FGF2 FGF18 ADIPOGENESIS%REACTOME DATABASE ID RELEASE 97%9843745 Adipogenesis MED13L FAM120B MED1 EBF2 MED4 MED6 MED7 TNF CEBPD EBF1 CCNC-1 PPARGC1A PPARGC1B CREBBP CCND3 SREBF2 WNT1 LEP MED16 MED17 MED12 MED14 MED13 MED10 CD36 NCOA1 NCOA2 MED19 NCOA6 MED15 NCOA3 MED18 MED11 MED27 MED23 NCOR2 NCOR1 MED26 MED24 MED29 WNT10B MED22 MED20 MED25 ANGPTL4 BMP7 ELOVL3 PLIN1 MED21 MBD3 GATAD2B GATAD2A FABP4 CDK4 UCP1 MED31-1 CHD9 EP300 ADIPOQ TBL1XR1 LPL MED30 HELZ2 CDK8 KLF4 CIDEA CHD4 CHD3 TGS1 RXRA CARM1 PPARG PPARA SMAD1 SMAD4 NR2F2 MED8 MED9 CEBPA HDAC2 SMARCD3 HDAC3 HDAC1 MTA1 RBBP4 TGFB1 CDK19 RBBP7 PRDM16 MTA2 MTA3 CEBPB ADIRF SLC2A4 ZNF638 RELA ZNF467 KLF5 HNRNPU MED28-1 EGR2 NFKB1 ZNF423 PCK1 THRAP3 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-HSA-8856688.2 Golgi-to-ER retrograde transport PLA2G4A RAB6B AGPAT3 CAPZA3 ACTR10 ARFGAP3 ARFGAP2 DCTN6 DCTN5 DCTN4 ARF4-1 NSF TMED2-1 RAB1A RAB1B RAB6A ACTR1A RAB18 RAB3GAP2 ARF1 RAB3GAP1 ZW10 GBF1 PAFAH1B1 DYNC1I2 DCTN2 DCTN3 KIF5B KIF5A COPB1 KIF21A KIF21B KIFAP3 KIF4B;KIF4A KIF16B KIF20A KIF20B KLC1 DYNC1H1 KLC4 KLC3 KLC2 RACGAP1 KIF3B KIF3C DYNC1LI1 KDELR1 DYNC1LI2 KIF18A KIF18B SURF4 KIF12 KIF11 DYNC1I1 KIF15 KIF19 CAPZB KIF13B KIF1C KIF1B KIF3A KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIF2A KIFC2 KIFC1 KIF2C KIF2B DCTN1 SEC22B CENPE KIF26A CAPZA1 KIF26B CAPZA2 BICD1 BICD2 GALNT2 PAFAH1B3 GALNT1 PAFAH1B2 RINT1 KDELR2 COPB2 COPA COPE USE1 TMED3 TMED7 TMED9 COPZ2 COPZ1 NAPB TMED10 ARF5 NBAS STX18 NAPG PLA2G6 BNIP1 ARCN1 COPG2 COPG1 NAPA ARFGAP1 KDELR3 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis HSD17B11 AKR1B15;AKR1B10 HSD17B1 HSD17B2 CYP19A1 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418346 Platelet homeostasis PDE11A PLA2G4A PDE10A KCNMB1 KCNMB2 KCNMA1 KCNMB3 GNG10 KCNMB4 NOS1 GNAS-1 PDE9A GNG2 GNG5 APOB NOS3 GNG4 GNG8 GNG13 GNB2 GNB1 GNB4 GNB3 ITPR1 ITPR2 GNB5 ITPR3 P2RX7 P2RX4 FGR TRPC7 PECAM1 PAFAH2 TRPC6 TRPC3 PRKG2 PPP2R1A PTPN11 PTPN6 PTGIR SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 ATP2B2 ATP2A1 NOS2 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 LRP8 P2RX6 GNGT1 P2RX5 P2RX3 STIM1 P2RX2 P2RX1 ORAI2 ORAI1 PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E MAPK14 GUCY1A2 PDE5A GUCY1A1 GUCY1B1 PDE1B PDE1A PDE2A IRAG1 DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants ALK ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion PLCB1 PLCB2 PRKCA GNA14 MARCKS GNA15 GNAQ GNA11 PLCB3 CHRM3 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9856651 MITF-M-dependent gene expression DPF1 DPF2 DPF3 AKT2 SMARCC1 SMARCC2 PPARGC1A RAB27A IRF4 SS18L1 SMARCA2 CDC25B SMARCA4 LEF1 SERPINE1 SS18 ACTL6A PXDN MET ATP6V1E1 CDKN1A SIRT1 ATP6V1G1 CTNNB1 BRCA1 TYRP1 TCF7 MYO5A CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 GXYLT2 TERT SYTL2 PMEL EDIL3 MLANA TBX2 MLPH TCF7L1 ATP6V0D1 ATP6V1A HINT1 SOX2 PXN SOX10 POU3F2 ATP6V1C1 CCNB1 CDK2 MAPK14 PLK1 ZEB1 ATP6V0B ATP6V1B2 ATP6V0C BCL2 GMPR ITGA2 TYR ACTB-1 CDH1 BCL7A STT3B SIN3A BCL7C BCL7B ATP6V0E2;ATP6V0E1 MYRIP BCL2A1 ARID1A TRPM1 ARID1B SMARCD1 SMARCD2 SMARCD3 HDAC1 DICER1 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 USF1 AGO3;AGO1 TNRC6B CCND1 LIG1 ATP6V1H SMARCE1 TFAP2A DIAPH1 BIRC7 GPR143 TCF7L2 MCM5 CDKN2A MCM2 CDH2 ASAH1 SMARCB1 DCT ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9034793 Activated NTRK3 signals through PLCG1 NTF3 PLCG1 NTRK3 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5609975 Diseases associated with glycosylation precursor biosynthesis DPM1 DOLK DPM2 DPM3 SRD5A3 GALM-2 GALE NUS1 GALT PGM1 GFPT1 MPI GNE DHDDS GALK1 PMM2 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters RUNX3 LEF1 TCF7L1 AXIN2 CTNNB1 MYC TCF7 TCF7L2 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358751 CTNNB1 S45 mutants aren't phosphorylated PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence CDK6 CDK4 CDKN2A FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease SOS1 FLT3LG PIK3CA PTPN11 CDKN1A GOLGB1 GAB2 BCL2L1 TRIP11 GRB2 SPTBN1 FLT3 UBA52 CBL NOX4 MYO18A STAT5A STAT5B ETV6 PIM1 ZMYM2 RPS27A UBB;UBC HRAS PIK3R1 NRAS REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 97%9824585 Regulation of MITF-M-dependent genes involved in pigmentation ACTL6A DPF1 DPF2 DPF3 AKT2 SMARCC1 USF1 SMARCC2 CTNNB1 TYRP1 TYR MYO5A SYTL2 ACTB-1 PMEL MLANA MLPH SMARCE1 TFAP2A RAB27A IRF4 BCL7A SS18L1 BCL7C SOX10 BCL7B SMARCA2 LEF1 SMARCA4 MYRIP GPR143 ARID1A ARID1B MAPK14 SMARCD1 SMARCB1 DCT SMARCD2 SS18 SMARCD3 RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT KIF14 PRC1 DLG4 MYL6 PPP1R12B CDKN1B MYH14 CIT MYH11 RAC1 MYH10 PPP1R12A RHOA RHOC MYL12B RHOB MYH9 PPP1CB MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-HSA-77286.4 mitochondrial fatty acid beta-oxidation of saturated fatty acids HADHB-1 MECR HADHA HADH ACADL ACADVL ACADM ECHS1 ACADS ACSM3 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains PAG1 LCK HLA-DPB1-1 HLA-DQB2;HLA-DQB1 CD3E CD3D HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 CD3G PTPRJ HLA-DRA PTPRC PTPN22 CSK CD4 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 97%3065679 SUMO is proteolytically processed SENP1 SUMO1 SENP5 SUMO3 SUMO2 SENP2 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 NGF HDAC1 PRDM4 NGFR HDAC2 HDAC3 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 97%5467333 APC truncation mutants are not K63 polyubiquitinated APC NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway HDAC1 SNW1 MAMLD1 HDAC10 NCOR2 KAT2B KAT2A NCOR1 HDAC11 HDAC4 CREBBP HDAC5 HDAC8 HDAC9 NOTCH1 HDAC6 HDAC7 RBPJ MAML2 MAML1 TBL1XR1 MAML3 NOTCH2 NOTCH3 NOTCH4 HDAC2 HDAC3 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 97%5610785 GLI3 is processed to GLI3R by the proteasome PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 GSK3B PRKACB-1 CSNK1A1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 GLI3 PSMA2-1 PSMA5 PRKACA-1 SEM1 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702577.2 semaxanib-resistant FLT3 mutants FLT3 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190322 FGFR4 ligand binding and activation FGF20 FGF23 FGF19 FGFR4 FGF6 FGF1 FGF4 FGF16 FGF9 FGF2 KLB FGF18 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism ABCC8 STX1A GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 CHRM3 AGPAT1 PRKAB2 GNG13 CACNB2 CACNB3 GNAQ CACNA2D2 GNB2 GNB1 GNB4 GNB3 ITPR1 ITPR2 GNB5 ITPR3 MLX IQGAP1 GNAI1 GNAI2 CD36 KCNC2 PRKAG2 GCGR GCG PRKACA-1 PPP2R1A KCNS3 ADRA2C ADRA2A KCNJ11 ACACB ACACA MARCKS RAPGEF3 PRKCA VAMP2 RAPGEF4 PRKAR2B PPP2CB;PPP2CA CACNA1A CACNA1D PPP2R5D CACNA1C KCNB1 PPP2R1B CACNA1E ADIPOQ KCNG2 SYT5 FASN ACSL4 ACSL3 STXBP1 ACLY GNAS-1 ADCY9 PRKAR1B PRKAR1A STK11 ADCY4 ADCY3 ADCY2 INS;INS-IGF2 ADCY1 ADCY8 ADCY7 PFKFB1 ADCY6 ADCY5 PRKACB-1 PRKAR2A FFAR1 SNAP25 AKAP5 PRKAA2 ADIPOR1 ADIPOR2 GNGT1 TALDO1 PLCB3 GLP1R SLC2A1 TKT SLC2A2 PLCB1 AHCYL1 PLCB2 RAP1A ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 97%203615 eNOS activation SPR NMT2 LYPLA1-1 ZDHHC21 CALM3;CALM1 CAV1 DDAH1 NOS3 CYGB HSP90AA1 NMT1 AKT1 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors OR52A5-2 OR2V2 OR11A1 OR8A1 OR8I2 OR10G9;OR10G7 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 LHX2 OR56B1-1 OR10W1 OR8B3;OR8B2-1 OR5B2 OR5D14 OR5D13 EBF1 OR52M1 OR10V1 OR4C12 OR6C3 OR5A2 OR5A1 OR4C15 OR9I1 OR2AG1;OR2AG2 OR10T2 OR52L1 OR4C45-1 OR52R1-2 OR6B2 OR6B1 OR2A25 OR51I2 OR2M2;OR2M3;OR2M7;OR2M5 OR10S1 OR51I1 OR4D11 OR4D10 OR2Z1 OR6A2 OR9G4 OR4E1 OR8K5-1 OR51Q1 OR2B6;OR2B2-1 OR4D9 OR5B12 OR5AP2 OR4D6 OR4D5 OR4D2 OR4D1 OR2H1-1 OR10Z1 OR2S2-1 OR5P2-4 OR4C6 OR4A15 OR4C3 OR3A2 OR3A1 OR8K3 OR8K1 OR4C11-1 OR2L3;OR2L8;OR2L2;OR2L5-1 OR5AN1 OR8U8;OR8U1;OR8U9 OR6C2;OR6C68 OR6F1 OR2T2;OR2T35 OR51M1 OR10X1 OR8J3-1 OR5C1 OR1C1 OR2G2-1 OR51D1 OR6M1 OR7E24-1 OR2T11 OR1L1;OR1L3;OR1L8 OR5AK2-2 OR2D3 OR2D2 OR1B1 OR52E4 OR5J2 OR52E2-1 OR2AT4-1 OR2C3 OR6K6 OR2C1 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 OR51B6 OR4F6 OR2B3 OR10K2 OR2F1-2 OR2T29;OR2T5-3 OR14A2-1 OR2AJ1 OR51A4 OR2A5 OR51A7 OR52J3 RTP2 RTP1 OR4M1 OR10R2 OR8U3 OR6Q1 OR11H1;OR11H12 OR52I1;OR52I2-1 OR4F21;OR4F16;OR4F29;OR4F3 OR9G9;OR9G1 OR7C1;OR7C2-9 OR51G2 OR51G1 OR1F1 OR2H2 OR4L1 OR5B3-13 OR6P1 OR10Q1 OR52E8;OR52E6 OR5M10;OR5M1-1 OR2AP1 OR2B11 OR4A47-3 OR51F2 OR5M9 OR51F1 OR2G6 OR4K5 OR4K3 OR5M3 OR4K2 OR4K1 OR10P1 OR51E1 OR1D2 OR51E2 OR6N2 OR6N1 OR4F15 LDB1 OR11H4 OR2M4 OR4C13;OR4C46-2 OR6K3-1 OR1K1 OR4K17 OR1S1;OR1S2 OR4Q3 OR11H6 OR8G1;OR8G5 OR1J4 OR11G2 OR1J2 OR4P4 OR1J1 OR10AD1 OR6T1 OR4K13 OR7A10;OR7A17-11 OR51V1-1 OR13J1 OR2K2 OR1I1 OR6S1 OR5M11 OR5K4-1 OR10D3 OR8H2;OR8H3;OR8H1 OR14K1 OR4N5 OR5P3 OR10C1 OR5B17-3 LOC112268384;OR2A42;OR2A1 OR6C6-1 OR11L1 OR10H1;OR10H5;OR10H2 OR5W2 OR6Y1 OR52B2 OR52B6 OR5K3-3 OR1A1-1 OR1N2 OR1N1 OR6X1 OR1E1;OR1E2 OR52K1-1 OR52A1 OR5L2;OR5L1-1 OR1M1 OR4S2 OR5AC2-2 OR2AE1-2 OR10G2 OR14A16 OR10G3 OR8D2-1 OR7D4-5 OR4K14-1 OR5T1 OR6V1 OR10G6 OR6C4-1 OR10K1-1 OR52W1 OR5AS1 OR4F5;OR4F17;OR4F4 OR2T6 OR13C9 OR2T1 OR13C8 OR2L13 OR4X1 OR9A4 OR51T1 OR5V1-2 OR5AR1 OR2V1-1 OR2A2;OR2A14 OR1Q1 OR12D1;OR12D2-1 OR51S1 OR7G2;OR7G1-14 OR14C36-8 OR5B21 OR2J1;OR2J2;OR2J3-2 REEP1 OR13A1 OR2T27;OR2T7 OR4N2-1 OR4C16-2 OR14J1 OR13H1 OR2Y1 OR8D4 OR56B4 OR8D1 OR6C70 OR6C76 OR6C75 OR6C74 OR13G1 OR13C3;OR13C4 OR4B1-2 OR10A7 OR1L4;OR1L6-1 OR6C1-1 OR56A4 OR10A4 OR56A3 OR10A3 OR10A5 OR2A7;LOC107987545;OR2A4 OR4A16;OR4A5-1 OR4X2-2 OR2W3 OR8B8 OR2W1 OR8B4 OR13F1 OR12D3 OR5AU1 OR2T12;OR2T33;OR2T8-1 OR5K1;OR5K2 OR10J1-2 POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296071 Potassium Channels KCNJ2 ABCC8 KCNJ12;KCNJ18 KCNJ3 KCNJ4 GNG10 GABBR2 KCNQ2 KCNQ3 GNG2 KCNJ5 GNG5 GABBR1 GNG4 KCNJ6 KCNJ10 ABCC9 GNG8 KCNJ9 KCNJ15 KCNK10 KCNJ16 KCNJ14 KCNK13 KCNK16 KCNK18-1 GNG13 KCNK17 KCNK2 GNB2 KCNK4 GNB1 GNB4 GNB3 GNB5 KCNK6 KCNK7 KCNK1 KCNN1 KCNN3 KCNN4 KCNC2 HCN4 HCN3 HCN2 HCN1 KCNS3 KCNJ11 KCND1 KCND2 KCND3 KCNB1 KCNG2 KCNK9 KCNMB1 KCNK3 KCNMB2 KCNMA1 KCNMB3 KCNMB4 KCNJ1 KCNJ8 KCNG1 KCNG3 KCNG4 KCNC1 KCNA1 KCNC3 KCNA2 KCNC4 KCNA3 KCNA4 KCNA6 KCNA7 KCNV1 KCNV2 KCNH1 KCNF1 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNB2 KCNAB1 KCNAB2 KCNAB3 KCNS1 KCNS2 KCNA10 KCNQ5 KCNQ4 KCNN2 GNGT1 KCNQ1 KCNA5 KCNH2 ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters SLC30A2 SLC30A8 SLC39A10 SLC30A5 SLC30A1 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A4 SLC39A1 SLC39A3 SLC30A3 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602571 TRAF3 deficiency - HSE TLR3 TICAM1 TRAF3 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 97%73728 RNA Polymerase I Promoter Opening UBTF H2AC20 PHF6 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MAPK3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 MBD2 H2BC1 H2AC14 H2BC21 TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656535 TGFBR1 LBD Mutants in Cancer TGFBR1-1 TGFBR2 FKBP1A TGFB1 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 97%2428924 IGF1R signaling cascade FGF20 FRS2 GAB1 SOS1 FGF23 FLT3LG PIK3CA PTPN11 AKT2 GAB2 IRS4 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 FGF10 FGF19 FGFR4 IRS2 FLT3 IGF1R PIK3R4 THEM4 IGF2 PDPK1 IGF1 TRIB3 IRS1 PIK3C3 PIK3R2 PIK3CB HRAS PIK3R1 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RBX1 CDK8 DLL4 PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 HDAC8 JAG1 ADAM10 HDAC9 NOTCH1 HDAC6 ADAM17 HDAC7 RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN NEURL1B MAML3 MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 UBA52 CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B CALCINEURIN ACTIVATES NFAT%REACTOME%R-HSA-2025928.4 Calcineurin activates NFAT CALM3;CALM1 PPP3CA PPP3CB PPP3R1 FKBP1A NFATC2 NFATC3 NFATC1 PPIA BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 97%9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 97%5654221 Phospholipase C-mediated cascade; FGFR2 FGF20 FGF23 FGF2 FGF7 FGF22 FGF3 FGF10 PLCG1 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 97%428890 Role of ABL in ROBO-SLIT signaling ABL2 CLASP1 ABL1 ROBO1 CAP1 CLASP2 SLIT2 CAP2 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%R-HSA-3371598.3 Defective BTD causes biotidinase deficiency BTD DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 NEIL1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-HSA-419408.5 Lysosphingolipid and LPA receptors LPAR3 PLPPR1 PLPPR2 PLPPR3 PLPPR4 PLPPR5 LPAR5 S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 LPAR1 LPAR2 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9955542 CPS1 variants cause CPS1 deficiency CPS1 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation TRAF6 IKBKB UBE2V1 IKBKG PELI1 CHUK UBE2N IRAK1 PELI3 PELI2 JOSEPHIN DOMAIN DUBS%REACTOME%R-HSA-5689877.3 Josephin domain DUBs RAD23B UBB;UBC PRKN RAD23A JOSD2 VCP-1 JOSD1 ATXN3 RPS27A UBA52 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%426486 Small interfering RNA (siRNA) biogenesis DICER1 AGO4 AGO2 AGO3;AGO1 TARBP2 PRKRA TSNAX TSN DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) SLC3A2 SLC7A7 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654693 FRS-mediated FGFR1 signaling FRS2 FGF20 SOS1 FGF23 PTPN11 FGF2 FGF22 FGF3 FGF10 HRAS FGF1 FGF6 FRS3 FGF4 NRAS FGF9 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9948011 CASP5 inflammasome assembly CASP5;CASP4 DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 97%5083635 Defective B3GALTL causes PpS ADAMTS2 ADAMTS3 ADAMTS1 ADAMTSL5 ADAMTSL4 ADAMTSL2 THSD7A ADAMTS8 ADAMTS6 ADAMTS7 ADAMTS9 SBSPON ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 ADAMTS19 ADAMTS17 ADAMTS13 ADAMTS16 ADAMTS18 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTSL3;ADAMTSL1 ADAMTS4 THBS1 ADAMTSL1 ADAMTS5 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772573 Late SARS-CoV-2 Infection Events FUT8 MAN2A1 GSK3B ST6GAL1 MOGS OST4 ACE2 UBE2I RPN2 OSTC STT3A RPN1 CSNK1A1 STT3B GSK3A ST3GAL4 ST6GALNAC2 PRKCSH ST3GAL1 MGAT4A-1 ST3GAL2 ST3GAL3 SUMO1 SRPK2 EDEM2 PARP16 DDOST PARP14 SRPK1 PARP10 DAD1 MAN1B1 ST6GALNAC3 ST6GALNAC4 MAGT1 PARP6 PARP4 GANAB PRMT1 ANO8 ANO9 ANO6 GALNT1 ANO4 PARP9 MGAT4C ANO5 MGAT4B ANO2 PARP8 ANO3 ANO1 CANX ZDHHC20 TMPRSS2 MGAT5 ANO10 MGAT1 UBA52 MGAT2 FURIN ZDHHC9 RPS27A TUSC3 UBB;UBC ZDHHC5 ZDHHC8 ZDHHC2 GOLGA7-1 ZDHHC3 TMEM258 PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 97%9629569 Protein hydroxylation U2AF2 ASPH KDM8 OGFOD1 JMJD4 F9 JMJD7 RCCD1 JMJD6 RIOX2 ZC3H15 RPS23 RWDD1 ETF1 RPS6 RIOX1 DRG1 DRG2 RPL27A RPL8 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 97%169131 Inhibition of PKR EIF2AK2 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 97%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TASOR PPHLN1 RBM7 H2AC20 MORC2 MPHOSPH8 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MTREX H2AC4 ATF7IP H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 ZCCHC8 H2BC15;H2BC3;H2BC11;H2BC12 EHMT2 H2BC5 EHMT1 SETDB1 H2BC1 H2AC14 H2BC21 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage PUDP TK2 UCK1 TK1 DCK UPP1 TYMP UCKL1 CDA INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%9006925 Intracellular signaling by second messengers FGF20 FGF23 INSR PIK3R3 PIK3R6 AKT2 PIK3R5 AKT3 CSNK2A1;CSNK2A3 BMI1 RING1 HDAC5 PSMD12 RNF2 PSMD11 PSMD14 HDAC7 PSMD13 REST CBX8 PSMA7 CBX6 PSMD8 PDE1C PHC2 PHC1 GRK2 PSMB6 PSMB7 CBX4 PSMD6 CBX2 PSMB4 PSMD7 PIP5K1A PIP5K1B PSMB5 PHC3 PSMB2 PIP5K1C PSMB3 PSMD2 EGF PSMD3 ERBB2 PLCG1 PSMB1 PSMD1 EGFR PDGFRA ADRM1 FGF6 PSMC2-1 PSMA2-1 PSMA5 XIAP PRKACA-1 HGF SEM1 PSMA6 GAB1 PSMC5 PPP2R1A PSMA3 MET PSMC6 PSMA4 AREG PSMC3 PSMA1 PRKCE PSMC4 PSMC1 FGF7 FGF22 FGF3 FGF10 KIT NTRK3 AKT1 UBA52 TSC2 PRKCD KDM1A PRKCA PRKAR2B RPS27A UBB;UBC KPNA2 CASP9 PREX2 PDE1B PDE1A IER3 FLT3LG PDGFB CD19 EGR1 BAD CD28 SNAI1 SNAI2 ADCY9 STRN RCOR1 GAB2 PRKAR1B PHLPP2 PRKAR1A PHLPP1 IL33 CD86 IRAK1 KLB ADCY4 CD80 ADCY3 ATN1 SALL4 ADCY2 MAF1 INS;INS-IGF2 ADCY1 PDGFRB ADCY8 FGF19 ADCY7 FGFR4 ADCY6 AKT1S1 ADCY5 IL1RL1 PRKACB-1 TRAT1 RPS6KB2 FLT3 PIK3AP1 PRKAR2A GSK3A TRIM27 USP13 TNKS TNKS2 RNF146 FRK PIP4K2A PDPK1 OTUD3 PIP4K2B CAMKK1 PTEN CAMKK2 PIP4K2C TRAF6 FYN MYD88 PTPN11 IRAK4 WWP2 FOXO4 FOXO3 CALM3;CALM1 EPGN NBEA TRIB3 STUB1 TGFA FOXO1-1 IRS2 ATF2 SGK1-1 PRKCG ITPR1 ITPR2 LCK ITPR3 RRAGA RRAGC RRAGB SRC RRAGD EZH2 MAPKAP1 JUN CDKN1A CDKN1B RAC1 CHUK RPTOR NRG1 NRG2 EREG BTC NRG3 NRG4 HBEGF MBD3 SUZ12 RICTOR NTF3 GATAD2B GATAD2A PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG LAMTOR2 LAMTOR1 LAMTOR4 PPP2R5E LAMTOR3 LAMTOR5 VAV1 USP7 MDM2-2 SLC38A9 FGF2 GSK3B MECOM NEDD4 RHEB CHD4 CHD3 ESR1 THEM4 PRR5 CAMK4 EED MLST8 PPARG PIK3CD PIK3CG TP53 IRS1 PIK3R2 ESR2 PIK3CB NR4A1 PIK3R1 NR2E1 CAMK2B CAMK2D HDAC2 CAMK2A HDAC3 FRS2 HDAC1 PIK3CA CAMK2G PML MTOR TNRC6C MOV10 MTA1 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 TNRC6B CSNK2B RBBP7 MTA2 MTA3 MKRN1 NTRK2 BDNF AHCYL1 PRKX MAPK1 MAPK3 FGF1 FGF4 FGF16 FGF9 FGF18 INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation ADAM15 ADAM19 SH3PXD2A ADAM12 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death RIPK3 FADD TLR3 TICAM1 CASP8 RIPK1 FORMATION OF LATERAL PLATE MESODERM%REACTOME%R-HSA-9758920.3 Formation of lateral plate mesoderm GATA4 BMP4 IHH FOXF1 SHH EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin SOS1 MMP3 PRKCA HRAS EGFR HBEGF NRAS INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9940951 Interaction of NuRD complexes with transcription factors HDAC1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 FBP1 MTA2 MTA3 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CHD3 G6PC1 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 MBD2 H2BC21 H2BC1 CHD5 GATAD2B IKZF1 GATAD2A IKZF2 IKZF3 H2AC20 PHF6 H2AB2;H2AB3;H2AB1 ZMYND8-1 H2AZ2;H2AZ1 ZNF687 TCF19 ZNF592 ZNF827 H2AC4 NR2F2 CDK2AP2 CDK2AP1 ZNF532 PCK1 HDAC2 NR2C2 H2AC14 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%6793080 rRNA modification in the mitochondrion MTERF4 NSUN4 RPUSD4 RPUSD3 TRUB2 MTERF3 TFB1M RCC1L NGRN MRM2 MRM3 FASTKD2 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase KCNE2 KCNE3 KCNE4 KCNE5 KCNQ1 KCNE1;KCNE1B CACNA1C CACNG6 CACNG7 CACNB2 CACNG8 CACNA2D2 CACNB1 AKAP9-1 CACNG4 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane UBE2V1 MAP2K6 IRAK1 IRAK2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 UBE2N ATF2 TAB3 TAB2 TAB1 APP NFKB2 TRAF6 TLR5 TP53 NOD1 NOD2 RIPK2 ALPK1 NLRX1 AGER S100A12 N4BP1 JUN PPP2R1A USP18;USP41 MYD88 MAPK7 NFKBIB SAA2;SAA1 NKIRAS1 BTRC NKIRAS2 IKBIP IRAK4 ECSIT SKP1 TRAF2 PELI1 CHUK CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 FBXW11 TIFA HMGB1-1 MAP3K1 IKBKB IKBKG FOS UBA52 NFKBIA CUL1 MAPKAPK2 RELA TLR10 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC NFKB1 RPS6KA1 MAP3K7 MAP2K2;MAP2K1 MAP3K8 MEF2A MAP2K3 MAPK1 MAPK14 MAP2K4 MEF2C MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat NCBP1 CCNT1 CDK7 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 NCBP2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 97%1222556 ROS and RNS production in phagocytes ATP6V0B HVCN1 ATP6V1B2 ATP6V1E1 ATP6V0C ATP6V1E2 ATP6V1B1 NOS1 ATP6V1G1 ATP6V1G2 NOS3 NOS2 ATP6V1H MPO ATP6V1G3 ATP6V0D1 ATP6V0D2 ATP6V1A ATP6V0A2 NCF1 ATP6V0A4 ATP6V0E2;ATP6V0E1 NCF2 ATP6V1D NCF4 ATP6V1C1 ATP6V1F LPO ATP6V0A1 ATP6V1C2 CYBB CYBA SLC11A1 TCIRG1 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9686347 Microbial modulation of RIPK1-mediated regulated necrosis RIPK3 MLKL CASP8 RIPK1 SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%6802949 Signaling by RAS mutants CAMK2G MARK3 MAP3K11 ARAF KRAS CALM3;CALM1 RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 PEBP1 JAK2 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF PHB MAPK3 KSR1 KSR2 CAMK2B CAMK2D BRAP CAMK2A RAP1B NRAS APBB1IP LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944971 Loss of Function of KMT2D in Kabuki Syndrome ASH2L WDR5 DPY30 RBBP5 KMT2D TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 97%69560 Transcriptional activation of p53 responsive genes TP53 PCBP4 CDKN1A ZNF385A GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation GNG10 GNAS-1 GNG2 GNG5 ADCY9 GNG4 PRKAR1B GNG8 PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 PRKACB-1 GNB2 PRKAR2A GNB1 GNB4 GNB3 PRKAR2B GCGR GCG PRKACA-1 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 97%9652817 Signaling by MAPK mutants DUSP8 DUSP9 DUSP6 MAPK1 DUSP7 DUSP16 DUSP10 SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 97%195721 Signaling by WNT AKT2 CSNK2A1;CSNK2A3 CSNK1G2 PSMD12 PSMD11 PSMD14 PSMD13 LEF1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 NFATC1 PIP5K1B PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PRKG2 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 SCRIB PSMC1 SKP1 CTNNB1 TCF7 CDC73 TERT LEO1 VPS29 BCL9L SOX3 TLE4 VPS35 VANGL2 TLE3 SOX6 TLE2 SOX7 TLE1 SOX4 AXIN2 TCF7L1 WLS PYGO1 WNT3A SOX13 BCL9 HECW1 PYGO2 VPS26A SOX2 CCDC88C RSPO2 XPO1 RSPO1 TLE5 RSPO4 AKT1 UBA52 TMED5 LGR6 LGR5 LGR4 CTNNBIP1 PRKCA KLHL12 CUL1 CBY1 YWHAZ DACT1 ZNRF3 RPS27A UBB;UBC MAP3K7 PRKCB TPTEP2-CSNK1E;CSNK1E DAAM1 RBX1 CAV1 CSNK1A1 TNKS TNKS2 RNF146 CUL3 CALM3;CALM1 ZRANB1 GNGT1 PLCB3 PLCB1 PLCB2 CTBP2 CTBP1 DVL1 DVL2 DVL3 H2AC14 USP8 WNT9A SFRP1 SFRP2 GNG10 WIF1 SOST GNG2 GNG5 GNG4 GNG8 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNG13 SNX3 CREBBP GNB2 GNB1 USP34 GNAT2 PRKCG GNB4 KAT5 WNT5B GNB3 RYK-1 ITPR1 WNT5A ITPR2 ROR1 GNB5 SMARCA4 ROR2 ITPR3 NLK PPP3R1 H2AC20 WNT1 FZD1 FZD3 H2AB2;H2AB3;H2AB1 FZD2 FZD5 FZD4 FZD7 FZD6 FZD8 PARD6A ASH2L GNAO1 CLTB ARRB2 PPP3CA PPP3CB PRKG1 PRICKLE1 PDE6B PDE6A RSPO3 RAC1 H2AJ PFN1 RHOA WNT10B WNT10A CLTC H2BC5 CLTA AP2A1 H2BC1 AP2B1 AP2A2 AP2S1 AMER1 PPP2CB;PPP2CA RAC3 WNT8A WNT8B AXIN1 PPP2R5B PPP2R5A EP300 PPP2R5D PPP2R5C FRAT2 WNT7B PPP2R1B MEN1 APC WNT7A H2AC4 PORCN PPP2R5E SOX17 KMT2B LRP5 LRP6 GSK3B WNT11 DPY30 SOX9 WNT4 CHD8 H2BC21 WNT9B WDR5 WNT6 H2AZ2;H2AZ1 WNT2 WNT3 SMURF2 SMURF1 DKK1 DKK2 WNT2B DKK4 MYC CAMK2A HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 TRRAP AGO2 RBBP5 AGO3;AGO1 WNT16 TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RUNX3 RNF43 H2BC15;H2BC3;H2BC11;H2BC12 SRY TCF7L2 KREMEN1 KREMEN2 RUVBL1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855167 Synthesis of pyrophosphates in the cytosol PPIP5K1 IP6K1 PPIP5K2 NUDT4;NUDT4B IP6K3 ITPK1 NUDT11;NUDT10-1 IPPK NUDT3 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 97%9014843 Interleukin-33 signaling IL1RL1 IL33 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia UGT1A1;UGT1A6 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 97%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) SLC6A19 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-HSA-418889.5 Ligand-independent caspase activation via DCC UNC5A DCC UNC5B CASP3 CASP9 DAPK1-1 DAPK2 DAPK3 APPL1 MAGED1 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events GNG10 RAMP2 GNG2 GNG5 GNG4 GRK5 GNG8 PDE3B AVPR2 GNG13 DRD1 GNB2 GNB1 ADM IAPP DRD5 GNB4 POMC CALCA GNB3 ADRB1 ADRB2 GNB5 HTR4 HTR6 HTR7 HRH2 CALCRL GRK2 SRC TAAR8 GIP TAAR9 TAAR6 TAAR5 ARRB2 TAAR2 GNAI1 TAAR1 ADORA2A ADRB3 GNAI2 GCGR GCG PRKACA-1 SCT RXFP1 RXFP2 GPR176 GHRHR GPR15 MC4R GPR27 GPR25 GPR20 PTH1R GPR32 PTH2R MC3R GPR45 MC1R MC5R PRKAR2B GPR150 LHCGR FSHR SCTR GPHA2 TSHR ADM2 GPHB5 GPR83 GPR84 CALCB;CALCA RLN3 PDE1B INSL3 PDE1A PDE2A ADCYAP1 ADCYAP1R1 PDE11A VIPR1 PDE10A VIPR2 LHB PTGDR ITGB1 GNAS-1 GIPR ADCY9 CRHR1 PRKAR1B PRKAR1A PDE3A CRH ADCY4 ADCY3 GPBAR1 ADCY2 ADCY1 ADCY8 PTGER4 ADCY7 ADCY6 RAMP3 ADCY5 PTH PRKACB-1 PTGER2 PRKAR2A RLN2;RLN1 GHRH RAMP1 FSHB PDE8B PDE8A CRHR2 GRK3 CALCR GRK6 CYSLTR2 GNAT3 PDE4D-1 ADORA2B GNAZ GNAI3 GPER1 PDE4A PTGIR PDE4C GLP2R CGA MC2R PTHLH GPR39 PDE7B VIP PDE7A ARRB1 NPSR1 GNGT1 NPS P2RY11 ITGA5 GLP1R AVP TSHB SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1660661 Sphingolipid de novo biosynthesis CERS1 CERS2 PPM1L SPHK2 OSBP KDSR SPNS2 FA2H ABCG2 VAPA VAPB CSNK1G2 MFSD2B SAMD8 SPTLC1 SPTLC3 SPTSSB SGMS1 SGMS2 SPHK1 CERS3 CERS4 ORMDL2 CERS5 PRKD3 CERS6 ORMDL3 PRKD2 DEGS1 PRKD1 DEGS2 ORMDL1 ABCC1 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 97%3248023 Regulation by TREX1 TREX1 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades S100A8 TLR2 MYD88 TLR3 LY96 IRAK4 CHUK TICAM1 BTK TLR7 CD14 HMGB1-1 TIRAP TLR4 IKBKB IKBKG FGB FGA NFKBIA UNC93B1 FGG RELA TLR10 NFKB2 TRAF3 TLR6 S100A1 TLR5 NFKB1 CD36 TLR1 S100A9 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK ARNTL CLOCK CSNK2A1;CSNK2A3 CDK5 CSNK2B ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions HSP90AB1 HSP90AA1 RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription RUNX3 SMAD2;SMAD3 BCL2L11 FOXO3 SMAD4 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%186763 Downstream signal transduction SOS1 PIK3CA PDGFB PTPN11 STAT3 GRB7 PDGFRB NCK2 CRK NCK1 STAT1 STAT6 STAT5A STAT5B BCAR1 SRC PIK3R2 PIK3CB PLCG1 RAPGEF1 HRAS PIK3R1 PDGFRA RASA1 CRKL NRAS RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%8951430 RUNX3 regulates WNT signaling RUNX3 LEF1 TCF7L1 CTNNB1 MYC TCF7 TCF7L2 CCND1 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 97%168330 Viral RNP Complexes in the Host Cell Nucleus HSPA1A;HSPA1B GLUCONEOGENESIS%REACTOME%R-HSA-70263.8 Gluconeogenesis ENO4 TPI1 GAPDH-1 PC SLC37A1 PGK1 FBP1 FBP2 PGAM1 PGAM2 ALDOC ALDOB ALDOA G6PC1 GAPDHS PCK1 G6PC2 GPI ENO1 G6PC3 ENO2 SLC37A4 PCK2 ENO3 DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 CBLIF AMN CUBN TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins GALNT1 PARP9 PARP8 CANX GSK3B ST6GAL1 MOGS UBE2I MGAT1 UBA52 GSK3A ST3GAL4 ST6GALNAC2 PRKCSH ST3GAL1 ST3GAL2 ST3GAL3 SUMO1 PARP16 PARP14 PARP10 RPS27A UBB;UBC ST6GALNAC3 ST6GALNAC4 PARP6 GANAB PARP4 RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle FRS2 WDR6 FAM83B GOLGA3 ANKRD26;CCDC144A;LOC105375816 DST KIDINS220 TXNL1 ARHGAP35 SCRIB LEMD3 CKAP4 KTN1 NISCH VANGL1 PTPN13 DEPDC1B VANGL2 UBXN11 DLG5 KCTD13 CAV1 DSG1 PKP4 RBMX EPHA2 UHRF1BP1L ARHGAP1 KIF14 PLXND1 LRRC1 RND2 PRAG1 NUDC TFRC PIK3R2 PIK3R1 ALDH3A2 TNFAIP1 FRS3 ARHGAP5 FNBP1 MUC13 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855183 Synthesis of IP2, IP, and Ins in the cytosol IMPA1 IMPA2 MIOX INPP5B INPP5A ISYNA1 INPP5J MTMR9 INPP4A OCRL SYNJ1 INPP4B INPP1 MTMR7 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation MAPKAPK5 BLM MDM2-2 CSNK2A1;CSNK2A3 STK11 CCNA2-1 CDK5 CCNA1 TAF9 PRKAB2 TP53RK PIN1 NOC2L MDM4 RAD9B KAT5 TAF9B CHEK2 CHEK1 RAD9A DYRK2 HUS1 TAF15 PRKAB1 EXO1 TAF12 TBP TAF13 TAF10 TAF11 SSRP1 TOPBP1 DNA2 RHNO1 TAF8 RFC5 RFC3 TAF7 RFC4 RFC2 TP53 TAF6 NUAK1 TAF5 TAF4 TAF3 ATRIP TAF2 TAF1 PRKAA1 BARD1 AURKB PLK3 TP53INP1 RBBP8 PRKAG2 TPX2 RAD17 ATM RAD50 ATR CSNK2A2 PRKAA2 PRKAG1 BRCA1 PRKAG3 SUPT16H CSNK2B RMI2 RMI1 TOP3A UBA52 WRN CDK5R1 AURKA RPA1 RPA2 HIPK1 CDK2 HIPK2 RPA3 RPS27A RAD1 TAF4B UBB;UBC TAF7L BRIP1 MRE11 MAPK14 MAPK11 NBN ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols NR1H4 CYP8B1 FDXR ARNT2 RXRA CYP7A1 CYP1B1 CYP11B1;CYP11B2 CYP39A1 CYP46A1 AHRR AHR CYP27A1 CYP21A2 CYP4V2 CYP51A1 ARNT CYP7B1 NCOA1 CYP19A1 NCOA2 FDX1 CYP11A1 POMC G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 CDK1 HDAC1 CDC6 TOP2A RBBP4 MAX CCNA2-1 CCNA1 LIN54 LIN37 LIN9 DYRK1A LIN52 PCNA CDC25A CDK2 MYBL2 E2F4-1 E2F5 TFDP1 RBL2 TFDP2 RBL1 CCNE2 CCNE1 MYC E2F1 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins RHOA RHOC RTKN LIN7B RHOB RHPN2 ROPN1;ROPN1B TAX1BP3 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764560 Regulation of CDH1 Gene Transcription SNAI1 SNAI2 KLF4 STRAP H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 TWIST2 SP1 H2BC21 SMARCA4 FOXA2 H2AC20 EED H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 WT1 EZH2 TGIF2 ARID1A HDAC2 HDAC1 SIRT1 RBBP4 ZNF217 H2AJ TCF12 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TLE1 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 H2BC5 H2BC1 KDM1A MPHOSPH8 ZMYM2 H2AC4 CTBP2 FOXQ1 CTBP1 DNTTIP1 ZBTB33 MAPK1 FOXP2 RB1 ZEB2 MAPK3 KMT5A PKM ZEB1 MCRIP1 FOXJ2 KLF9 H2AC14 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 97%168333 NEP NS2 Interacts with the Cellular Export Machinery NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS XPO1 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 RAN NUP37 NDC1 SEC13 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390650 Histamine receptors HRH3 HRH2 HRH4 HRH1 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%421270 Cell-cell junction organization CSNK2A1;CSNK2A3 NECTIN2 MOGS RPN2 RPN1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 CLDN2 PIP5K1C PSMB3 PSMD2 ZC3H12A PCSK7 PSMD3 ANK3 CLDN6 CLDN4 PSMB1 PSMD1 CLDN3 CLDN9 CLDN8 JAK1 CLDN7 ADRM1 CADM3 PSMC2-1 CADM1 CADM2 PSMA2-1 PSMA5 XIAP CLDN23-1 SEM1 PSMA6 CLDN20 PSMC5 TYK2 CLDN11 PSMA3 CLDN10 PSMC6 CTNND1 MTBP PSMA4 CLDN15 RACK1 CLDN14 CBLL1 CLDN12 PSMC3 PSMA1 CLDN19 EPS15 CLDN18 PSMC4 CLDN17 PSMC1 CTNNB1 BIRC2 CLDN16 ADAM33 CANX CDH9 CDH8 PCSK6 CDH7 CDH6 CDH3 TLE1 ADAM19 CDH24 SDK1 SDK2 CLDN22;CLDN24-1 CDH10 UBA52 CDH12 CDH13 CDH17 CDH18 KDM1A CDH19 PARD6G NECTIN4 MPP5 NECTIN3 NECTIN1 RPS27A CRB3 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 STAT3 SNAI1 CLDN5 SNAI2 CDH1 JUP OST4 OSTC STT3A ANG JAK2 SP1 PRKCSH F11R DDOST PARD3 DAD1 CDC42 IL6ST GANAB CTSS FARP2 CTSB CTSV;CTSL IL6R FURIN CDH4 CTBP2 CDH2 CTBP1 RB1 CDH15 H2AC14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A SEC11C SMARCA4 FOXA2 CDH5 H2AC20 H2AB2;H2AB3;H2AB1 SRC EZH2 TGIF2 PARD6B PARD6A PRKCI SPCS3 SPCS2 SPCS1 BANP SIRT1 RAC1 H2AJ TCF12 CLDN1 ANGPTL4 ELMO1 DOCK1 SUZ12 H2BC5 H2BC1 SOX10 DNM2 MPHOSPH8 HEYL PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 H2AC4 VAV2 HACE1 KMT5A ARHGEF4 MDM2-2 CTNNA1 KLF4 STRAP TWIST2 H2BC21 VCL RNF19B EED WT1 H2AZ2;H2AZ1 ARID1A MYC HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 CDH11 AGO3;AGO1 ZNF217 TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 TIAM1 PVR RELA TRAF7 ZMYM2 NFKB1 IL6 MAPK1 POMT2 MAPK3 PATJ POMT1 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 97%9673163 Oleoyl-phe metabolism PM20D1 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP1 IGF2BP3 IGF2BP2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304349 Loss of Function of SMAD2 3 in Cancer TGFBR1-1 TGFBR2 SMAD2;SMAD3 TGFB1 SMAD4 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 97%9956529 ASL variants cause argininosuccinate aciduria ASL NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription HES1 MAMLD1 GZMH;GZMB-1 RBPJ MAML3 NOTCH2 MAML2 EP300 FCER2 MAML1 HES5 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 BRCA2 RAD51AP1 DNA2 XRCC2 PALB2 BRIP1 MRE11 NBN BARD1 RBBP8 SEM1 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation MARK3 ARAF RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 WDR83 PEBP1 IL17RD FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 LAMTOR2 ARRB2 MAP2K2;MAP2K1 LAMTOR3 RAP1A CSK MAPK1 HRAS BRAF MAPK3 KSR1 KSR2 RAP1B NRAS APBB1IP GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%6787639 GDP-fucose biosynthesis FPGT GFUS GMDS FCSK SLC35C1 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654719 SHC-mediated cascade:FGFR4 FGF20 SOS1 FGF23 FGF2 KLB FGF19 FGFR4 HRAS FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112307 Transmission across Electrical Synapses GJC1 GJA10 GJD2 PANX1 PANX2 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 97%1592389 Activation of Matrix Metalloproteinases MMP25 MMP24 CTSK TIMP2 KLK3;KLK2 CTSG TIMP1 CTSV;CTSL CTRB1;CTRB2 MMP7 MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 MMP11 MMP14 MMP13 MMP16 MMP15 MMP17 TPSAB1;TPSB2;TPSD1 FURIN PLG SPOCK3 CMA1 PRSS3;PRSS2;PRSS1 ELANE KLKB1 COL18A1 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions MAOA PAOX MAOB CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC20 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 CDC14A INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 97%264876 Insulin processing STX1A EXOC8 P4HB EXOC7 MYO5A EXOC4 EXOC3 EXOC6 EXOC5 INS;INS-IGF2 EXOC2 EXOC1 PCSK2 RAB27A ERO1B KIF5C SLC30A8 SLC30A5 VAMP2 MYRIP KIF5B KIF5A PCSK1 CLTRN CPE DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME DATABASE ID RELEASE 97%5619066 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC22A18 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family SLC30A2 SLC30A8 SLC30A5 SLC30A1 SLC30A3 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 PTEN AGO3;AGO1 TNRC6B TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC28A2 SLC25A5 SLC25A4 SLC29A1 ARL2 SLC28A1 SLC29A3 SLC29A2 SLC28A3 SLC25A6 ARL2BP SLC29A4 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin SOCS3 IRS1 PTPN11 STAT5A STAT3 STAT5B IRS2 JAK2 LEP CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 97%1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants CBL GAB1 SOS1 PIK3CA HSP90AA1 RPS27A UBB;UBC EGF CDC37 SHC1-1 PLCG1 EGFR HRAS PIK3R1 NRAS UBA52 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 97%9927020 Heme assimilation HBA2;HBA1 HBD;HBB SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 97%8985586 SLIT2:ROBO1 increases RHOA activity RHOA ROBO1 MYO9B SLIT2 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 97%1614558 Degradation of cysteine and homocysteine FMO1 CSAD SUOX GOT2-1 TXN2 TST MPST CDO1 TSTD1 GADL1 ADO ETHE1 SQOR CTH SLC25A10 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.3 Regulation of HSF1-mediated heat shock response NUP133 NUP50 POM121;POM121C NUP54 GSK3B NUP42 HSPA2 NUP43 RAE1 RANBP2 NUP35 YWHAE HIKESHI CCAR2 NUP37 DNAJC2 DNAJC7 ST13;LOC107986532 RPS19BP1 HSPA4L HSPA14 HSPA13 ATM DNAJB1 HSPH1 BAG5 ATR DNAJB6 NUP107 SIRT1 BAG3 NUP188 BAG1 HSPA1L HSF1 HSPA4 HSPA6 HSPA12A HSPA12B HSPA5 NUP210 NUP93 BAG4 BAG2 HSPA1A;HSPA1B NUP205 AAAS HSPA9 NUP160 NUP85 NUP214 TPR NUP88 NUP155 RPA1 MAPKAPK2 RPA2 NUP153 RPA3 HSPA8 NUP62 MAPK1 MAPK3 NDC1 SEC13 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways SFN PSMC6 SMAD2;SMAD3 YWHAZ YWHAQ YWHAH PDPK1 YWHAG EP300 SMAD4 YWHAE YWHAB CAV1 UBE2I SP1 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane PIKFYVE MTMR4 PIK3C3 MTM1 FIG4 MTMR2 MTMR7 PIK3C2A VAC14 PIK3R4 MTMR9 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK SOS1 PRKCA MAPK7 RPS6KA3 MMP3 RPS6KA2 RPS6KA1 EGFR MAPK1 HRAS GAST MAPK3 HBEGF NRAS CCKBR CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 97%177162 Conjugation of phenylacetate with glutamine ACSM1 ACSM2A;ACSM2B GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%70326 Glucose metabolism NUP133 NUP50 HKDC1 POM121;POM121C NUP54 PGK1 FBP1 FBP2 PFKFB2 PFKFB1 PFKFB4 NUP42 PFKFB3 PRKACB-1 G6PC1 G6PC2 ENO1 G6PC3 ENO2 NUP43 ENO3 GNPDA1 ENO4 RAE1 GNPDA2 RANBP2 SLC37A1 NUP35 ALDOC ALDOB ADPGK ALDOA NUP37 SLC37A4 PRKACA-1 PPP2R1A NUP107 NUP188 BPGM NUP210 PC PGM2L1 NUP93 PFKL PGAM1 PGAM2 NUP205 PFKM AAAS PFKP GPI NUP160 NUP85 NUP214 TPR NUP88 GCKR NUP155 GCK TPI1 NUP153 PPP2CB;PPP2CA PPP2R5D GAPDH-1 HK2 PPP2R1B HK1 HK3 NUP62 GAPDHS PCK1 PCK2 NDC1 SEC13 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) HYAL1 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy MAP1LC3B2;MAP1LC3B-1 VPS18 VPS41 UVRAG VPS16 VPS45 VPS33A VPS33B TUFM VPS11 VPS39 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.5 Chromatin organization MORF4L1-2 SUPT7L BRMS1 KAT6B MORF4L2 SNRPD2 HAT1 ENY2 SNRPD1 TAF5L KDM4C-1 ATXN7 EP400 SNRPD3 SMYD3 DMAP1 COPRS MRGBP RIOX2 TADA1 BRWD1 KDM5A KDM5B KDM5C VPS72 KDM6B MSL2 H2BC18 MSL1 KDM7A KDM3A KDM3B HDAC8 KDM4A KDM4B KDM4D SNRPE-2 USP22 MSL3-1 REST CLOCK NFKB2 PRMT1 MAFK NFE2L2 CTNNB1 CDC73 LEO1 AXIN2 PAX3 RPS2 KDM1A CHD9 CHD2 PHF21A SNRPF RCOR1 SNRPB HMG20B G6PC1 JAK2 BCL11B PHF10 SNRPG-2 SUPT16H SNRPA1 WDR61 SMARCB1 PCK1 EHMT2 EHMT1 H2AC14 SAP130 DPF1 PHF5A DPF2 DPF3 KAT8 SMARCC1 SNRPN SMARCC2 HCFC1 TAF9 OGT-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP ATF2 SETDB1 SS18L1 SETD1B KAT5 SETD1A SMARCA2 SMARCA4 TADA2A ZZZ3 H2AC20 TAF12 H2AB2;H2AB3;H2AB1 TAF10 EZH2 SSRP1 CBX3-1 PHF20 SUV39H1 MEAF6 ASH2L SGF29 NCOA1 NCOA2 SS18 ACTL6A NCOR2 KAT2B H2AJ KAT2A TCF12 ING5 NCOR1 AEBP2 PRMT5 BRD1 GPS2 SF3B1 MBD3 SUZ12 BRPF3-1 H2BC5 MCRS1 MBD2 H2BC1 BRD7 GATAD2B GATAD2A CDK4 ARID4B EP300 H2AC4 SAP30 TBL1XR1 KMT5A KMT2D KMT2A KMT2C KMT2B TCF4 KAT6A SMYD2-1 MBIP SUDS3 DR1 CTR9 RTF1 BRPF1 YEATS2 ACTB-1 MYOG TADA3 PAF1 FBP1 DHX15 MECOM MYOD1 DPY30 UBE2I CHD4 CHD3 CHD8 CHD7 BCL7A CHD6 CTCF NKD2 H2BC21 FAM124B BCL7C IGF2 BCL7B PWWP2B DDX46 DDX42 CHD5 IKZF1 WDR5 IKZF2 SUMO1 RBM17 IKZF3 KDM6A PHF6 MBD3L1 EED ZMYND8-1 DNMT3A CARM1 PWWP2A H2AZ2;H2AZ1 ADNP2 ARID1A ZNF687 ARID1B TCF19 ADNP ZNF592 ZNF827 SMNDC1 CBX1 U2SURP NR2F2 MBD3L2;MBD3L2B;MBD3L5;MBD3L3;MBD3L4 CDK2AP2 CDK2AP1 ZNF532 DKK2 SMARCD1 SMARCD2 HDAC2 SMARCD3 NR2C2 HDAC3 HDAC1 SF3B4 SF3B5 MTA1 SF3B2 HDAC10 SF3B3 NQO1 RBBP4 TRRAP SF3B6 EPC1 RBBP5 SUPT20H SAP30L PRDM7;PRDM9 SF3A3 WDR77 SF3A1 JMJD6 SF3A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 PADI3 CCND1 BICRAL PADI2 BICRA SAP18 PADI4 BRD9 PADI1 PADI6 RBBP7 PRDM16 MTA2 TADA2B MTA3 PHF2 SUV39H2 SMARCE1 SETD2 CHERP ATF7IP SETD3 SETD6 SETD7 H2BC15;H2BC3;H2BC11;H2BC12 PHF8 KANSL1 ING4 ING3 KANSL2 PRMT6 PBRM1 KANSL3 PRMT7 ACTL6B PRMT3 ASH1L PUF60 SUPT3H SNRPB2 TAF6L DOT1L RELA NSD3 NSD1 NSD2 BCL11A BRD8 ELP1 ELP2 ELP3 ELP4 ELP5 H2AC16;H2AC11 ELP6 KDM1B NFKB1 JADE1 ARID4A YEATS4 JADE3 JADE2 RUVBL2 RUVBL1 KMT5B ARID2 KDM2A KDM2B KMT5C ARID5B HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling APOC2 ALB CETP ABCG1 APOC3 APOE APOA1 LIPG LCAT AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 ATP6V0B ATP6V1B2 DEPDC5 ATP6V0C ATP6V1B1 SLC38A9 BMT2 ATP6V1G3 SEH1L RHEB WDR59 MIOS WDR24 ATP6V0E2;ATP6V0E1 RRAGA RRAGC RRAGB MLST8 RRAGD FNIP1 FNIP2 C12orf66 ITFG2 KPTN MTOR ATP6V1E1 SZT2 ATP6V1E2 ATP6V1G1 ATP6V1G2 FLCN RPTOR ATP6V1H ATP6V0D1 ATP6V0D2 ATP6V1A NPRL2 NPRL3 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 CASTOR1 CASTOR2 LAMTOR2 SESN1 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SESN2 SH3BP4 TCIRG1 SEC13 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H SSB NFIX POLR2L NFIA NFIB NFIC ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 BRF2 TBP BDP1 POU2F1 GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR1C GTF3C5 POLR1D BRF1 GTF3A GTF3C6-1 CRCP RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 97%392517 Rap1 signalling RAPGEF3 YWHAZ RAPGEF4 RAP1GAP SIPA1 RAP1GAP2 RAP1A RAF1 YWHAB RASGRP2 RASGRP1 PRKACB-1 RAP1B PRKACA-1 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system RPS14 RPS17 TBK1 RPS16 PTK2B RPS19 IL21 TNFRSF13C RPS18 AKT2 GBP2;GBP3;GBP1 AKT3 RPS11 B2M RPS10 RELB S1PR1 RPS13 VIM RPS12 CD40LG TNF STX4 IL4R IL13 VCAM1 IRF4 CCL3L1;CCL3L3;CCL3;CCL18 ITGB2 TNFSF13B POMC IRF8 SFN STAT6 APP STAT5A STAT5B NFKB2 POU2F1 RPS25 RPS27 CASP1 RPS29 SDC1 RPS20 RPS21 BATF RPS24 IL4 RPS23 IL5 PLCG1 JAK1 RIPK2 RAP1B PRKACA-1 HGF PPP2R1A TYK2 IL17RC TNFRSF1A BTRC HSPA1L TNFRSF14 IL17RA BIRC2 SKP1 BIRC3 HSP90AA1 CANX FBXW11 RPS27L RPS15A RPS3 SOX2 UBA52 RPS2 STAT1 STAT2 CUL1 CSF1 IL17F FAU ATF1 RPS27A MAP3K14 ELK1 IL17A EDA RPS6KA3 TNFRSF13B RPS6KA5 EDA2R TNFRSF8 KPNA2 RPS6KA2 UBB;UBC MAP3K7 TNFRSF4 RPS6KA1 GSDMD EDARADD MAP3K8 RPS9 MEF2A RPS7 TNFRSF12A MAP2K3 RPS8 TNFRSF1B MAP2K4 RPS5 EDAR MEF2C LTA RPS6 MAPKAPK3 TNFRSF25 LTB MAPK9 RPSA TNFRSF11B MAPK8 TNFRSF11A MAP2K7 HSP90B1 TNFRSF17 MAPK10 TNFSF18 TNIP2 TNFSF14 CDK1 CD70 TNFSF15 TNFRSF9 TNFSF4 TNFSF9 BCL2L11 CD27 UBE2V1 TNFSF8 STAT3 BCL2 LTBR IFNAR1 BCL2L1 IRAK1 IRAK2 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E COL1A2 IL9 IL9R MAVS SQSTM1 JAK2 FLT3 UBE2N TAB3 TAB2 TAB1 ADAM17 RPS4X IRF1 RPS3A IRF2 IL23R IL23A IRF3 IL18 TRAF3 IL1A CDC42 IL1B TRAF6 IRF7 SH2B3 BECN1 RORC NOD1 NOD2 CAPZA1 EIF4A2 EIF4A1 IFNB1-4 PTPN11 CASP3 CTSG TIMP1 PTPN7 IL34 GAB3 EIF4E EIF2S2 FOXO3 EIF2S3;EIF2S3B PTPRJ ALOX15 EIF2S1 MMP1 NOS2 MMP2 MMP3 MMP9 PITPNA LMNB1 CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 PAK2 IL12RB2 CD44 IL10 SERPINB2 LAMA5 ANXA2 MSN MIF TNFRSF18 FURIN RALA-1 SOD2 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 LCP1 SPHK1 IL2RA TCP1 PTPN4 MT2A YES1 DUSP4 FOXO1-1 DUSP3 VRK3 DUSP6 DUSP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 VEGFA ATF2 SMAD2;SMAD3 SMARCA4 IL2 IL3 JUNB CD36 TARBP2 PRKRA JUN MAPK7 CDKN1A UBE2D3-1 ARF1 CDKN1B RPLP0 FPR1 CRK FOS TNFSF11 CBL SOCS3 VAMP2 CSF2 PTPN1 EIF4A3 NPM1-2 MAP2K6 FCER2 THOC5 ACTB-1 FANCC KPNB1 OPRD1 BCL6 IL21R HSPA2 PIN1 LIFR PIK3CD SMAD7 BIRC5 YBX1 SOCS6 OPRM1 SOCS5 CAMK2B CAMK2D CAMK2A PML CAMK2G FASLG TRAF2 CASP8 SHC1-1 F13A1 ANXA1 LYN UBE2D3;UBE2D2 NFKBIA PTAFR SLA2 TSLP IFITM3;IFITM2;IFITM1 IL31RA IL18BP CCR2 IFNL2;IFNL3;IFNL1 MAP2K2;MAP2K1 EIF2AK2 STX3 RAPGEF1 CRLF2 MAPK1 SLA MAPK3 CRKL GBP5-1 CIITA TRIM68 TRIM62 TRIM22;TRIM34;TRIM6-TRIM34 SOS1 STX1A GRB10 IFNGR1 TRIM46 PIK3R3 IFNGR2 TRIM45 IL2RB P4HB TRIM35 TRIM38 TRIM31 IL36A IL36B TRIM29 TRIM26 BRWD1 TRIM14 TRIM10 CD4 IL36G EIF3C;EIF3CL MUC1 EIF1AY;EIF1AX IL1F10 LCN2 IL20 EIF3M IL25 EIF3K IL26 EIF3L IL24 EIF3I PSMD12 EIF3J IL11 EIF3G PSMD11 EIF3H IL15 PSMD14 EIF3E IL19 PSMD13 EIF3F IL16 SNCA EIF3D EIF3A PSMA7 EIF3B DNAJC3-1 PSMD8 PGGT1B MAP3K3 PSMB6 IL31 PSMB7 PSMD6 IL37 PSMB4 OSM PSMD7 IL18R1 PSMB5 PSMB2 PSMB3 RAG2 PSMD2 RAG1 PSMD3 PSMB1 PSMD1 IL36RN IFIT1 IFIT3 ADRM1 IFIT2 IL7R PSMC2-1 PSMA2-1 PSMA5 IL1RL2 SEM1 TEC PSMA6 CNTF PSMC5 PSMA3 MX1-1 PSMC6 TOLLIP PSMA4 PSMC3 PSMA1 IL10RB PSMC4 CLCF1 PSMC1 CSF3 IL5RA GSTO1 IL13RA2 IL13RA1 ILF2 RAF1 HSPA1A;HSPA1B IL1RN IFIT5 IL1R2 AKT1 STXBP2 NUP214 LIF PRKCD YWHAZ MAPKAPK2 LBP IL11RA OASL OAS1 OAS3 ITGAM IL20RA IL20RB IL22RA2 IRF5 IL22RA1 HSPA8 MAPK14 RNASEL MAPK11 CTF1 ZEB1 FLNB EIF4G1 NANOG;NANOGP8 TXLNA FSCN1 IL1RAPL1 PTPN9 FLT3LG PTPN5 PTPN2 EGR1 RBX1 IFI35 RSAD2 SAMHD1 GRAP2 GAB2 IL33 CD86 OSMR CD80 IP6K2 IL17C IL1RL1 MID1 ISG20 IL7 IRF6 IRF9 CNTFR SNAP25 KPNA4-1 FN1 TRIM8 TRIM6 TRIM5 TRIM2 SYK TRIM3 HAVCR2 EBI3 HCK IL27 IL6ST CRLF1 HRAS FNTA IL27RA FYN FCGR1A CSF3R LGALS9C;LGALS9;LGALS9B ALPK1 NCAM1 NLRX1 NRAS AGER S100A12 FLNA N4BP1 USP18;USP41 NDN MYD88 NFKBIB PTPN20 SAA2;SAA1 NUP107 PTPN23 NKIRAS1 NKIRAS2 NUP188 IKBIP IL3RA EIF4E2 IRAK4 PLCG2 PELI1 PTPN14 PDE12 LRRC14 KPNA1 SP100 USP14 NUP210 PELI3 PELI2 DHX9 IFNLR1 NLRC5 IL17RE TIFA BST2 IL17RB HMGB1-1 GRB2 NUP93 IL22 IL18RAP SIGIRR IRAK3 NUP205 ABCE1 AAAS IL6R NUP160 NUP85 TPR NUP88 NUP155 TALDO1 NUP153 PTGS2-2 ELOC-1 NUP62 ELOB CCR5 NDC1 SEC13 ABL2 PTPN18 IL10RA NUP133 NUP50 POM121;POM121C CSF2RB NUP54 CSF2RA MCL1 GSTA3;GSTA5;GSTA1;GSTA2 CEBPD CISH IRS2 AIP NUP42 NCK1 PRL PRLR GHR SOCS2 SOCS1 NUP43 IL1R1 DUS2 RAE1 LCK RANBP2 SOS2 SRC FAAP24 LOC105377022;FANCB FAAP100 CENPX NUP35 FANCM FANCL FANCA FANCE CSK FANCG FANCF NUP37 CXCL8 FNTB;CHURC1-FNTB CHUK INPPL1 BLNK UBA7 HSPA5 CXCL2;CXCL3;CXCL1-1 DDX58 CCL13;CCL2 EIF2AK3 CCL11 ISG15 PTPN13 UBE2L6 IFI44L CCL4L2;CCL4L1;CCL4 HERC5 IFIH1 IKBKB GBP6 CCL5 TRIM25 ARIH1 IKBKG ATF6 CCL19 FKBP5 CCR1 CCL22 CCL20 ITGAX CXCL10 TRIM21 PPP2CB;PPP2CA ILF3 PIM1 PPP2R5A KPNA7 PPP2R5D KPNA5 KPNA3 PPP2R1B VAV1 ADAR PPM1B RHOU MAOA CA1 ITGB1 GATA3 INPP5D FGF2 NEDD4 UBE2I RORA PIAS1 HLA-DPB1-1 HLA-DQB2;HLA-DQB1 SUMO1 HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ACTG1 HLA-DRA PPIA GBP7;GBP4 IRS1 TP53 PIK3R2 PIK3CB MTAP PIK3R1 PSMB8 IL2RG HIF1A PTPRZ1 CUL5 MYC CENPS-CORT;CORT;CENPS JAK3 PIK3CA PTPN6 HMOX1 TGFB1 CCND1 KRAS ALOX5 UBA3 EIF4G3 EIF4G2 EIF4E3 HSPA9 CSF1R UBE2D1 PTPN12 RELA UBE2E1 NFKB1 IL6 RNF7 IFI30 ICAM1 RPS15 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 97%156590 Glutathione conjugation MGST3 MGST1 MGST2 CNDP2 GSTT1 GSTO2 GSTT2B;GSTT2 HPGDS GSTO1 GGT1 GSTA3;GSTA5;GSTA1;GSTA2 GSTZ1 GSTK1 GSTA3;GSTA1 GGT5 GGT7 CHAC2 GGT6 CHAC1 GSTP1 GGCT GCLC GCLM ESD OPLAH GSTM4 GSTM3 AKR1A1 GSTM1;GSTM2-1 GSS GSTA4 ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%9927354 ICOS co-stimulation PIK3CD PIK3CG PIK3CA PIK3R2 PIK3CB LOC102723996;ICOSLG PIK3R3 PIK3R1 PIK3R6 PIK3R5 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion F8 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390648 Muscarinic acetylcholine receptors CHRM2 CHRM1 CHRM4 CHRM5 CHRM3 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9675108 Nervous system development RPS14 RPS17 SPTBN2 RPS16 RPS19 CLASP2 RPS18 LIMK2 LIMK1 CSNK2A1;CSNK2A3 RPS11 RPL10A RPS10 RPS13 RPS12 SDC2 CNTN1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 DLG1 RPS23 ERBB2 PLCG1 NRP1 EGFR RPL36AL-1 PRKACA-1 GAB1 MET MYO10 HSP90AA1 RPS27L RPS15A GPC1 RPS3 CYP51A1 UBA52 NELL2 RPS2 SLIT3 RPL18A KIF4B;KIF4A ST8SIA2 FAU AGRN RPS27A RPS6KA3 RPS6KA5 CLASP1 RPS6KA2 UBB;UBC RPS6KA1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA CNTN6 CHL1 ITGA2 ITGA10 ANK1 UNC5A GRIN2B DCC UNC5B UNC5C UNC5D NTN1 ADAM10 HSP90AB1 RPS4X RPS3A PSEN1 NCSTN CDC42 COL9A1 ST8SIA4 COL9A3 COL9A2 LAMC1 PTPN11 RPL15-1 MMP2 MMP9 PITPNA RPS6KA6 CFL1 PAK2 DLG3 MSN ITGA5 YAP1-1 LAMB1 WWTR1 CACNA1H YES1 GRIN1 MYH9 SMARCA4 LDB1 RPL10;RPL10L-1 POU3F1 MAPK7 TEAD1 RPLP0 ARHGAP35 RAC1 RPLP2 RPL36-1 RHOA DOK1 DOCK1 SOX10 POU3F2 ITGA2B PSEN2 APH1A APH1B PLXNA4 ABL1 FLRT3 EIF4A3 RPL22L1 CASC3 ITGAV CDK5 ACTB-1 PSENEN RPL37A-1 MAG GSK3B RBM8A MAGOH;MAGOHB UPF3B RNPS1 PIK3CD TRPC7 TRPC5 TRPC6 TRPC3 TRPC4 TRPC1 HDAC2 RPL13A-1 CXCL12 DOK2 SHC1-1 PRKCQ ITGB3 LYN TIAM1 CDK5R1 RPL23A MBP MAP2K2;MAP2K1 ADGRV1 MAPK1 SEMA5A MAPK3 MPZ ADGRG6 HMGCR SOS1 GRB10 PIK3R3 MSI1 HOXA2 ISL1 COL4A5 GSPT2 GSPT1 LHX3 LHX2 LHX4 LHX9 USP33 ROBO1 UPF2 ETF1 ZSWIM8 SLIT1 PRX RPL27A PSMD12 PSMD11 PSMD14 PSMD13 WASL PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 PSMD3 ANK3 PSMB1 PMP22 PSMD1 EPHA4 ADRM1 ROCK1 PSMC2-1 PSMA2-1 COL4A2 PSMA5 COL4A1 COL4A4 SEM1 PSMA6 COL6A2 PSMC5 PSMA3 COL4A3 PSMC6 COL6A1 PSMA4 PSMC3 PSMA1 PSMC4 COL6A3 PSMC1 COL6A6 COL6A5 EPHA2 PRKCA RPL12-1 TRIO ITSN1 HSPA8 PABPC1;PABPC3 EIF4G1 MYL6 RBX1 NGEF TREM2 GAB2 TYROBP NUMB RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 PRKACB-1 RPL34 PRKAR2A SDCBP RPL8 ARPC1B ARPC1A RPL9 RPL6 RPL7 RPL35 RPL38 DAG1 RPL39 RPL21 RPL23 RPL22 HRAS FYN RASA1 CACNA1G CACNA1I NRTN RPL24 NCAM1 NRAS CACNA1S RPL27 PRNP PSPN RPL26 GFRA2 RPL29 GFRA4 RPL28 ARTN FARP2 CNTN2 RPL3L RPLP1-2 DPYSL4 DPYSL5 DPYSL2 DPYSL3 PLXNC1 SEMA6A SEMA6D PLXND1 ITGA1 SEMA7A SEMA3A ALCAM CRMP1 SCN11A SEMA3E SCN10A RRAS AGAP2 PLXNA2 L1CAM PLXNA3 LYPLA2 SEMA4A DSCAML1 CD72 SHC3 SEMA4D RAP1GAP PTPRC DAB1 FES PTPRA PLXNB3 CNTNAP1 SPTB ITGA9 ELOC-1 NTN4 ABLIM1 RPL11 NEO1 ABLIM2 RPL14 ABLIM3 NFASC ELOB RPL13 EPHB6 RPL18 RPS6KA4 RPL17 CACNB1 EPHB2 RPL19 CACNB4 EPHB1 EPHB4 SCN1B PLXNA1 EPHB3 ABL2 SCN1A SRGAP3 EPHA5 NCBP1 SRGAP2 EPHA7 SRGAP1 EPHA6 ARPC4 EPHA8 ARPC5 ANK2 SHTN1 KCNQ2 KCNQ3 ARPC2 EPHA1 ARPC3 EPHA3 SPTBN4 SPTBN5 PLXNB1 EPHA10 MYL12A SCN3B SCN3A CD24 SCN2A SCN2B NRP2 VLDLR CAP1 CXCR4 NCK2 GFRA3 IRS2 RGMB CACNB2 NCK1 RGMA CACNB3 RELN CAP2 ACTR2 SCN9A NRCAM DSCAM DOK4 DOK5 SCN8A DOK6 EFNA5 EFNA4 EVL TLN1 SREBF2 SPTA1 EFNB2 PFN2-1 EFNB1 SOS2 EFNB3 ROCK2 EFNA1 SRC EFNA3 EFNA2 NCBP2-1 HJV SCN5A GAP43 DCX SCN4A CLTB SCN4B SHANK3 LAMA1 PPP3CB SCN7A PDLIM7 CLTCL1 RPL7A NCAN DRP2 PFN1 GRB7 UTRN RPL35A KALRN MYL12B SPTBN1 CLTC PTK2 CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 LAMA2 SPTAN1 GIT1 CACNA1D VAV3 CACNA1C RHOC VAV2 RHOB SIAH2 SIAH1 ARHGEF7 ITGB1 ROBO2 RET PAK1 PAK3 PAK5 PAK4 MYO9B SLIT2 GFRA1 BUB1B-PAK6;PAK6 VASP ARHGAP39 GDNF ENAH ACTG1 PIK3R2 PIK3CB PIK3R1 CUL2 AKAP5 FRS2 ARHGEF28 PIK3CA CSNK2A2 SCD5 RANBP9 MYH14 MYH11 EZR MYH10 CSNK2B RPL5-1 RDX DLG4 ACTR3-1 RND1 NAB1 NAB2 ARHGEF11 ARHGEF12 SH3KBP1 EGR2 RPS15 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 97%1480926 O2 CO2 exchange in erythrocytes CYB5R1 CYB5R4 CYB5RL HBA2;HBA1 CA1 AQP1 CA2 CA4 HBD;HBB CYB5R2 RHAG SLC4A1 DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%9675143 Diseases of the neuronal system OPN1MW3;OPN1MW2;OPN1MW;OPN1LW TTR NAPEPLD LRAT RDH5 STRA6 RDH12 OPN1SW RBP4 RLBP1 ABCA4 RBP1 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.9 Interferon alpha beta signaling EGR1 IFI35 RSAD2 GBP2;GBP3;GBP1 IFNAR1 SAMHD1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E KPNB1 IP6K2 IRF4 ISG20 SOCS1 IRF6 IRF9 IRF8 IRF1 IRF2 IRF3 IRF7 IFIT1 IFIT3 JAK1 PSMB8 IFIT2 IFNB1-4 TYK2 USP18;USP41 PTPN11 MX1-1 PTPN6 KPNA1 ISG15 BST2 ABCE1 IFIT5 UBA52 SOCS3 STAT1 STAT2 PTPN1 OASL OAS1 OAS3 RPS27A IFITM3;IFITM2;IFITM1 IRF5 UBB;UBC EIF2AK2 RNASEL ADAR NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 97%187024 NGF-independant TRKA activation ADCYAP1R1 ADORA2A NTRK1 ADCYAP1 NTRK2 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190374 FGFR1c and Klotho ligand binding and activation FGF23 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 97%68616 Assembly of the ORC complex at the origin of replication ORC2 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ KPNA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2AC4 KPNA6 KPNB1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 ORC5 H2BC5 ORC4 ORC6 ORC1 H2BC1 H2AC14 ORC3 H2BC21 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 97%8939245 RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 BLK ELF1 ELF2 PAX5 CBFB METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids NR1H4 PLAAT1 PTGIS G0S2 PLA2G4A NR1H3 PLAAT3 PLAAT2 PLAAT5 GPCPD1 PLAAT4 HADHA ARSD-1 PITPNM1 PITPNM3 PITPNM2 CSNK2A1;CSNK2A3 B4GALT6 MGLL PLA2G1B TM7SF2 B4GALT5 AGPAT1 PPP1CC PON3 AGPAT2 PTGES3-1 ALPG;ALPP;ALPI-1 HPGD SELENOI PON2 AGPAT3 AGPAT4 GPAT4 PON1 AWAT2 GPAT3 LTC4S GPAT2 CEPT1 CDIPT SAR1B PLA2G10;LOC100652777 PLA2G2F BCHE CSNK1G2 PLA2G2D SGPP2 PIK3R4 PLA2G2E SGPP1 AGK POMC PNPLA8 PIKFYVE INSIG2 MBOAT7 INSIG1 MBOAT1 DDHD2 ALOX5AP ST3GAL2 MTM1 MBOAT2 ST3GAL3 DDHD1 ETNPPL OSBPL9 GPAM LPCAT4 ETNK2 RAB4A LPCAT3 OSBPL7 ETNK1 OSBPL6 LPCAT2 OSBPL3 OSBPL2 PNPLA3 CHPT1 M6PR LPIN1 LPIN2 SYNJ2 LPIN3 PNPLA2 SYNJ1 NFYA-1 RAB5A GAL3ST1 PIK3C2G PIK3C2A PPP1CB PIK3C2B PRKACA-1 HMGCS2 LBR GGPS1 FAAH2 APOA2 APOA1 APOA5 ALOXE3 CYP51A1 RAB14 VAPA VAPB SEC24D-1 GBA2 CPT1A SLC51A SLC51B CPT1B TIAM2 CYP2U1 SLC22A5 LHB HELZ2 UGCG SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CAV1 CYP7B1 ACBD5-1 GDPD1 GDPD3 GDPD5 CYP7A1 SPTSSB CBR4 ACOT2;ACOT1 PIK3C3 PTGES2 SEC23A NFYB NFYC GRHL1 SEC24B SEC24A HADH SEC24C IDI1 IDI2 ALOX15 ALOX12 CYP4F3;CYP4F2;CYP4F12;CYP4F11 AMACR PI4KA PI4KB SPHK1 CYP2R1 LSS THRAP3 LIPE VAC14 GBA FAM120B MED1 ACSL1 MED4 MED6 MED7 NSDHL ALDH3B2;ALDH3B1 PEX11A STARD3 STARD4 CCNC-1 STARD5 STARD6 PPARGC1A RUFY1 PPARGC1B CREBBP CIDEC MTMR1 HACD1 MTMR2 MTMR3 ABCB4 MTMR8 MTMR9 MTMR4 HACD3 MED16 HACD2 MED17 MED12 MTMR6 MED14 HACD4 MED13 MTMR7 MED10 CD36 HSD11B1 HSD11B2 NCOA1 UGT8 NCOA2 NCOA6 ELOVL5 NCOA3 ABCA1 B3GALNT1 MED27 ARF1 MED23 NCOR2 AACS NCOR1 MED24 ELOVL1 ELOVL4 MED20 ELOVL2 PLIN2 ANGPTL4 ELOVL3 PLIN1 GPS2 ELOVL6 ELOVL7 PTGR2 SUMF2 SUMF1 BDH2 BDH1 FABP4 MED31-1 PTGS1 EP300 GC TBL1XR1 FASN GK FABP9 FABP1 ACSL4 FABP2 ACSL3 FABP3 HSD3B1;HSD3B2 MED30 FABP5 FABP6 FABP7 MORC2 PECR CDK8 HMGCS1-1 HPGDS OSBP SULT2A1-4 KPNB1 CYP19A1 ACAT2 ACAT1 SIN3A PMVK THEM5 THEM4 HACL1 SRD5A2 SRD5A1 SRD5A3 B3GALT4 SLCO1A2 ABCD1 FHL2 PIK3CD PIK3CG ME1 ARNT SLC25A17 ACSS3 SMARCD3 HDAC3 ST6GALNAC5 ST6GALNAC6 PPM1L HSD17B13 HSD17B12 LRP2 HSD17B11 SCD SLC25A20 THRSP MMAA ACAD11 ACAD10 PTGR1-1 ARSA PIK3R3 PHYH-4 PIK3R6 PIK3R5 ARSL ARSJ ARSK ARSH ARSI ST8SIA5 ARSG SCP2 HMGCLL1 CTSA PRKAB2 TPTE;TPTE2 ACER2 ACER1 ACER3 CH25H RGL1 MOGAT3 MOGAT2 MOGAT1 TECR AKR1B1 FAR1 FAR2 ARV1 CLOCK SPTLC1 ACADL SPTLC3 AGMO ACADM ACADS PIP5K1A PIP5K1B LTA4H PIP5K1C STARD3NL GSTM4 PRXL2B CYP2J2-1 LGMN MTMR10 AKR1D1 MTMR12 RXRB MTMR14 PLEKHA1 MED19 PLEKHA2 PRKAG2 MED15 ACAA1-1 MED18 PLEKHA5 SMPD3 PLEKHA6 MED11 PLEKHA3 PLEKHA4 SMPD2 PPP1CA SMPD4 PLEKHA8 SMPD1 TSPO ACAA2 EHHADH-1 CYP46A1 SPHK2 SBF1 MED26 PCCA GGT1 MED29 SBF2 PCCB MED22 DPEP2 ACACB MED25 DPEP1 ACACA CYP21A2 FUT2 MED21 FUT1 AGPS EBP ACSBG1 CYP11A1 ACSBG2 PPARD GGT5 FDPS SAMD8 MAPKAPK2 ABCB11 CHD9 CPT2 A4GALT CRAT SLC27A1 FADS2 NUDT19 FADS1 ACLY MVD SLC27A3 SLC27A2 SLC27A5 MVK HMGCL NRF1 NPAS2 MBTPS1 CYP24A1 KDSR MBTPS2 BMX PRKACB-1 SP1 TBXAS1 FDXR CYP1B1 OSBPL1A PIP4K2A ALAS1 PIP4K2B PTEN MMUT PIP4K2C ACOT9 CUBN ACOT8 MECR ACOT7 CERS3 MED8 CERS4 MED9 CERS5 CERS6 FDX1 CERS1 TNFRSF21 ACOT4 CERS2 PRKAA2 AWAT1 CDK19 FA2H TSPOAP1 MID1IP1 CYP4B1 CYP1A1 CERK SERPINA6 ECI1 PIP4P1 STS LDLRAP1 MFSD2B BAAT CYP39A1 TRIB3 PTGS2-2 NEU2 ASAH1 NEU3 ASAH2 NEU1 SC5D B4GALNT1 DECR2 DECR1 SLC10A1 SLC10A2 MED13L AGT FIG4 AHR FABP12 CROT SREBF1 SREBF2 ABHD5 CYP4F22 HSD17B3 HSD17B4 PSAP FITM1 ESRRA FITM2 DHCR24 HSD17B7 TECRL HSD17B8 ALB DHCR7 CYP17A1 RAN HSD17B1 ORMDL2 HSD17B2 ORMDL3 HEXB GM2A PNPLA7 HEXA ORMDL1 GLB1L3 GPX1 GLB1L2 CYP8B1 GPX4 NUDT7 GLB1L NDUFAB1 GLB1 PNPLA4 PNPLA5 PNPLA6 CBR1-1 ARSB INPPL1 MSMO1 TXNRD1 PTPN13 ENPP6 ENPP7 ACOT11 ACOT12 ACOT13 FAAH ACSM3 GDE1 PTGDS SACM1L ACSL6 ACSL5 INPP4A CYP27A1 DHRS7B PLPP6 INPP4B OXCT1-1 PLPP3 PLPP2 PLPP1 PTGES DEGS1 DEGS2 TNFAIP8 CYP27B1 ACOXL AKR1B15;AKR1B10 SGPL1 INPP5F INPP5D INPP5E INPP5J ACOX2 INPP5K ACOX3 SCAP PIAS4 CIDEA ALOX15B STAR UBE2I GK2 VDR NR1H2 TGS1 RORA GLIPR1 HSD3B7 ANKRD1 TNFAIP8L1 TNFAIP8L3 RXRA TNFAIP8L2 GALC SUMO2 CYP11B1;CYP11B2 CARM1 PPARG PPARA GLA PI4K2B ECHS1 B3GNT5 PIK3R2 PIK3CB LPGAT1 PITPNB CPNE7 CPNE6 PIK3R1 PRKD3 LCLAT1 PLB1 PRKD2 PLA2G2A-1 LIPI PRKD1 LIPH PI4K2A JMJD7-PLA2G4B;PLA2G4B ALOX12B CPNE3 MFSD2A DGAT2 ARNTL MIGA2 PCYT2 PIK3CA MIGA1 DGAT1 STARD7 ARNT2 CSNK2A2 OLAH GPD1L-1 PISD ST3GAL5 SCD5 PLA2G15 ABHD3-2 CGA GNPAT PHOSPHO1 FDFT1 GPD2 NR1D1 GPD1 MCAT CSNK2B SQLE PGP PLBD1 PLA2R1 SPNS2 PLA1A OCRL CYP2D6;LOC107987479;LOC107987478-1 CDS1 CYP2C9;CYP2C19 ABHD4 EPHX2 PPT1 ALOX5 CHAT CYP1A2 PLD4 PLA2G3 PPT2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCG2 CYP2E1 PLD6 PLA2G5 PLD1 PLA2G6 PLD3 ACBD7 PLD2 ACBD6 PGS1 ACBD4 PTDSS2 PTDSS1 PTPMT1 MCEE OSBPL8 ACSF3 TMEM86B CHKB ACSF2 OSBPL5 CHKA STARD10 DGAT2L6 MTF1 CRLS1 PLIN3 PEMT ACADVL AHRR CDS2 ABCD3 SLC44A5 ACHE MED28-1 SLC44A3 HADHB-1 SGMS1 SLC44A4 SGMS2 SLC44A1 SLC44A2 LPCAT1 PCTP TAZ OSBPL10 ACP6 AGPAT5-1 PCYT1B PLA2G12A PLA2G4F PCYT1A ABCC3 ABCC1 PLA2G4D PLA2G4E SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions SLC25A11 SLC16A8 SLC16A3 SLCO2A1 SLC5A7 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC10A6 BSG SLC5A8 SLC16A7 EMB SLC16A1 SLCO1A2 SLC22A12 SLC44A5 SLC44A3 SLC22A8 SLC44A4 SLC44A1 SLC44A2 SLC25A1 SLC17A5 SLC22A6 AVP SLC5A12 SLCO4C1 SLCO2B1 SLC16A2 SLC13A5 SLC13A2 SLC13A3 SLCO1C1 SLCO4A1 SLC25A10 FLT3 MUTANTS BIND TKIS%REACTOME%R-HSA-9702509.2 FLT3 mutants bind TKIs FLT3 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 97%5362768 Hh mutants are degraded by ERAD PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 VCP-1 SHH PSMB4 RPS27A PSMD7 SYVN1 DERL2 ERLEC1 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 OS9 PSMD3 PSMB1 PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69109 Leading Strand Synthesis PRIM2 PRIM1 POLA1 POLA2 POLD3 POLD4 POLD2 RFC5 RFC3 RFC4 RFC2 RFC1 POLD1 PCNA MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 97%8949215 Mitochondrial calcium ion transport MICU3 PMPCA MICU2 MICU1 MCU SLC8A3 VDAC2-1 AKAP1 VDAC3 STOML2 MCUB VDAC1 SPG7 PHB MAIP1 PHB2 PARL AFG3L2 LETM1 SMDT1 SLC8B1 YME1L1 PMPCB NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 97%383280 Nuclear Receptor transcription pathway RARG MED1 NCOR2 NR1D1 NCOR1 NR2F1 RARB HNF4G NR0B2 NR2F6 RXRG HNF4A THRB VDR NR1H2 RORA ESR1 NR2C1 NR4A2 NR5A1 PPARD AR RXRA RARA PGR PPARG PPARA ESRRA NRBP1 ESR2 NR4A1 THRA RORC NR2E1 RORB RXRB NR2C2AP NR2C2 ESRRB ESRRG NR1D2 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 97%2160456 Phenylketonuria PAH DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o DPM1 DPM2 DPM3 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes CXXC1 MBIP TASP1 KAT8 PHF20L1 RBBP5 DR1 KAT2B HCFC2 KAT2A YEATS2 HCFC1 TADA3 WDR82 PAXIP1 AKAP8L PSIP1 DPY30 OGT-1 PAGR1 KANSL1 MCRS1 KANSL2 SETD1B KANSL3 SETD1A WDR5 TADA2A ZZZ3 KDM6A PHF20 ASH2L MEN1 SGF29 BOD1L2;BOD1 KMT2D KMT2A KMT2C NCOA6 KMT2B BOD1L1 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022923 DS-GAG biosynthesis BCAN VCAN DSE DCN CHST15 CSPG5 UST NCAN CHST14 DSEL BGN RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%110381 Resolution of AP sites via the single-nucleotide replacement pathway POLB APEX1 LIG3 XRCC1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 97%9648025 EML4 and NUDC in mitotic spindle formation NUP133 DYNC1LI1 DYNC1LI2 KIF18A BUB1 NDC80 RANGAP1 CLASP2 CENPN-2 MIS12-1 BUB1B CDCA8 CDC20 SKA1 PPP1CC SKA2 BUB3 MAD2L1 DYNC1I1 SPDL1 NUP43 B9D2 SPC24 SPC25 RANBP2 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP NSL1 RPS27 KNTC1 CENPA BIRC5 CENPE CENPC SGO1 NUP37 SGO2 AURKB CENPS-CORT;CORT;CENPS MAPRE1-1 PPP2R1A CENPT NUP107 CENPU KNL1 ZW10 CENPF CENPH CENPI TAOK1 DSN1 CENPK CENPL CKAP5 EML4 CENPM NEK9 RCC2 NEK6 NEK7 ZWINT XPO1 CENPO NUP160 CENPP AHCTF1 PAFAH1B1 NUP85 CENPQ DYNC1I2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E CLIP1 MAD1L1 DYNC1H1 NDE1 ITGB3BP PLK1 SEC13 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8963888 Chylomicron assembly APOC2 MTTP P4HB APOA2 APOC3 APOE APOB SAR1B APOA1 APOA4 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654704 SHC-mediated cascade:FGFR3 FGF20 SOS1 FGF23 HRAS FGF1 FGF4 FGF16 NRAS FGF9 FGF2 FGF18 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs ABRAXAS2 MYSM1 PSMD14 STAMBPL1 STAMBP H2AC20 KAT2B BRCA1 EP300 RPS27A H2AC16;H2AC11 H2AC4 UBB;UBC NLRP3 BABAM1 BABAM2 UIMC1 ABRAXAS1 BRCC3 BARD1 STAM UBA52 H2AC14 TRANSCRIPTIONAL REGULATION OF MULTICILIOGENESIS%REACTOME DATABASE ID RELEASE 97%9945556 Transcriptional regulation of multiciliogenesis RFX2 RFX3 CCNO TNRC6C MOV10 TP73 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 GRHL3 TNRC6B GRHL2 DEUP1 GMNC FOXJ1 MYB NOTCH1 DLL1 E2F4-1 E2F5 TFDP1 GMNN GRHL1 MCIDAS BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 97%194068 Bile acid and bile salt metabolism SLC10A1 NR1H4 CYP8B1 SLC10A2 FABP6 SLC27A2 SLC27A5 CYP46A1 OSBP ACOX2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 STARD5 CYP7B1 HSD3B7 CH25H RXRA AMACR CYP7A1 OSBPL1A OSBPL9 BAAT OSBPL7 CYP39A1 SLCO1A2 ABCB11 OSBPL6 ABCD3 HSD17B4 OSBPL3 OSBPL2 ACOT8 CYP27A1 ALB SLC51A SLC51B AKR1D1 NCOA1 NCOA2 ABCC3 ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 97%418990 Adherens junctions interactions CSNK2A1;CSNK2A3 NECTIN2 MOGS RPN2 RPN1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 ZC3H12A PCSK7 PSMD3 ANK3 PSMB1 PSMD1 JAK1 ADRM1 CADM3 PSMC2-1 CADM1 CADM2 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PSMC5 TYK2 PSMA3 PSMC6 CTNND1 MTBP PSMA4 RACK1 CBLL1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 BIRC2 ADAM33 CANX CDH9 CDH8 PCSK6 CDH7 CDH6 CDH3 TLE1 ADAM19 CDH24 CDH10 UBA52 CDH12 CDH13 CDH17 CDH18 KDM1A CDH19 NECTIN4 NECTIN3 NECTIN1 RPS27A UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 STAT3 SNAI1 SNAI2 CDH1 JUP OST4 OSTC STT3A ANG JAK2 SP1 PRKCSH DDOST DAD1 CDC42 IL6ST GANAB CTSS FARP2 CTSB CTSV;CTSL IL6R FURIN CDH4 CTBP2 CDH2 CTBP1 RB1 CDH15 H2AC14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A SEC11C SMARCA4 FOXA2 CDH5 H2AC20 H2AB2;H2AB3;H2AB1 SRC EZH2 TGIF2 SPCS3 SPCS2 SPCS1 BANP SIRT1 RAC1 H2AJ TCF12 ANGPTL4 ELMO1 DOCK1 SUZ12 H2BC5 H2BC1 SOX10 DNM2 MPHOSPH8 HEYL PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 H2AC4 VAV2 HACE1 KMT5A ARHGEF4 MDM2-2 CTNNA1 KLF4 STRAP TWIST2 H2BC21 VCL RNF19B EED WT1 H2AZ2;H2AZ1 ARID1A MYC HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 CDH11 AGO3;AGO1 ZNF217 TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 TIAM1 PVR RELA TRAF7 ZMYM2 NFKB1 IL6 MAPK1 POMT2 MAPK3 POMT1 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis COASY PPCDC PPCS PANK3 PANK1 DCAKD AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) DERL3 DERL1 PRKAB2 PSMD12 PSMD11 PSMD14 PSMD13 PRKAB1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 ERLEC1 PSMB5 CD274 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 PRKAA1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PRKAG2 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PRKAA2 PSMC4 PRKAG1 PSMC1 PRKAG3 UBA52 ERLIN1 ERLIN2 VCP-1 RPS27A DERL2 RNF5 UBB;UBC OS9 RNF185 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex RBX1 GSK3B CSNK1A1 PSMD12 PSMD11 PSMD14 PSMD13 LEF1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 HDAC1 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CTNNB1 TCF7 TLE4 TLE3 TLE2 TLE1 TCF7L1 ZRANB1 TLE5 UBA52 CUL1 AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D TCF7L2 PPP2R5C RPS27A FRAT2 PPP2R1B APC PPP2R5E UBB;UBC CTBP2 CTBP1 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME DATABASE ID RELEASE 97%9006821 Alternative Lengthening of Telomeres (ALT) DAXX ATRX SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 97%9669933 Signaling by kinase domain mutants of KIT KIT G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events ADRA2C GNG10 ADRA2A GNAS-1 GNG2 PRKCE ADRA2B GNG5 ADCY9 GNG4 GNG8 ADCY4 ADCY3 ADCY2 RGS20 ADCY1 ADCY8 PRKCQ ADCY7 ADCY6 ADCY5 GNG13 GNB2 RGS17 GNB1 RGS19 PRKCG GNB4 RGS16 GNB3 GNGT1 PRKCD PRKCA GNB5 GNAT3 RGSL1 GNAI1 GNAZ GNAI3 GNAI2 PRKCH RGS4 PRKCB CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) DHCR24 DHCR7 SC5D EBP LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 97%391906 Leukotriene receptors LTB4R2 GPR17 LTB4R CYSLTR1 CYSLTR2 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855204 Synthesis of IP3 and IP4 in the cytosol INPP5B PLCG2 PLCD3 INPPL1 PLCD4 INPP5D PLCD1 INPP5J CALM3;CALM1 OCRL PLD4 PLCH1 PLCH2 PLCE1 ITPK1 ITPKB PTEN ITPKC PLCB3 PLCB4 ITPKA PLCB1 PLCB2 PLCZ1 SYNJ1 PLCG1 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity USP8 CBL MET PTPN1 PTPN2 EPS15 SH3GL2 SH3KBP1 PTPRJ RPS27A HGS UBB;UBC SH3GL3 STAM SH3GL1 STAM2 LRIG1 UBA52 HGF ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 97%71384 Ethanol oxidation ALDH2 ADH5 ALDH1B1 ADH4 ACSS2 ADH1C;ADH1B;ADH1A ALDH1A1 ACSS1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%376172 DSCAM interactions DCC NTN1 DSCAML1 DSCAM RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 97%5627083 RHO GTPases regulate CFTR trafficking RHOQ GOPC CFTR VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins GNG10 GNAS-1 GNG2 GNG5 ADCY9 GNG4 PRKAR1B GNG8 PRKAR1A ADCY4 ADCY3 AVPR2 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 RAB11FIP2 ADCY5 GNG13 MYO5B PRKACB-1 GNB2 PRKAR2A GNB1 RAB11A AQP4 GNB4 GNB3 AQP2 GNGT1 AQP3 GNB5 AQP1 PRKAR2B AVP PRKACA-1 ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins PRSS3;PRSS2;PRSS1 DEFA6;DEFA4;DEFA5 CD4 ART1 DEPURINATION%REACTOME DATABASE ID RELEASE 97%73927 Depurination NEIL3 H2AC20 ACD H2AB2;H2AB3;H2AB1 TINF2 H2AZ2;H2AZ1 H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MPG H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 OGG1 H2BC1 H2AC14 H2BC21 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 97%918233 TRAF3-dependent IRF activation pathway IFNB1-4 TBK1 SIKE1 IRF3 EP300 DDX58 TRAF3 IRF7 RNF135 IFIH1 TRIM25 IKBKE MAVS CREBBP RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 97%6802953 RAS signaling downstream of NF1 loss-of-function variants NF1 SPRED3 SPRED2 SPRED1 HRAS NRAS SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation TASL IRF5 IKBKB IKBKG SLC15A4 CHUK SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 97%9034015 Signaling by NTRK3 (TRKC) SOS1 PIK3CA NTF3 BAX SRC IRS1 PLCG1 HRAS PIK3R1 NELFB PTPRO NTRK3 PTPRS NRAS SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin GAB1 SOS1 PIK3CA EPO STAT5A STAT5B PIK3R5 PLCG2 PIK3CD PIK3CG SHC1-1 PIK3CB VAV1 RAPGEF1 PLCG1 EPOR HRAS PIK3R1 IRS2 CRKL JAK2 LYN NRAS CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 97%5637810 Constitutive Signaling by EGFRvIII CBL GAB1 SOS1 PIK3CA HSP90AA1 EGF CDC37 SHC1-1 PLCG1 EGFR HRAS PIK3R1 NRAS RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 97%6811440 Retrograde transport at the Trans-Golgi-Network SCOC RAB6A COG4 VAMP4 SYS1 COG3 GCC1 COG2 RGP1 GOLGA1 ARFIP2 IGF2R GCC2 ARL1 RABEPK RAB6B NAA30 NAA35 NAPB NAA38 TMF1 NAPG STX10 ARFRP1 VPS51 VPS53 VPS52 RAB9A VPS54 COG1 RAB9B GOLGA4 PLIN3 NAPA M6PR TGOLN2 NSF STX16 VAMP3 RHOBTB3 STX6 VTI1A COG8 COG7 RIC1 COG6 USP6NL COG5 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%2173788 Downregulation of TGF-beta receptor signaling SMAD2;SMAD3 PPP1CA PMEPA1 TGFB1 RPS27A PPP1CC SMURF2 SMURF1 TGFBR1-1 MTMR4 TGFBR2 UBB;UBC UCHL5 SMAD7 STRAP PPP1R15A USP15 NEDD4L STUB1 XPO1 PPP1CB UBA52 BAMBI GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) PYGL GAA AGL-1 PHKG1 PHKB PHKG2 CALM3;CALM1 PGM1 GYG2 GYG1 PYGB PHKA1 PHKA2 PYGM REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation TNRC6C NPAS4 MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 97%446205 Synthesis of GDP-mannose HK1 GMPPB GMPPA PMM1 MPI PMM2 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-HSA-9754119.3 Drug-mediated inhibition of CDK4 CDK6 activity CDK6 CDK4 CCND3 CCND2 CCND1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.12 Metabolism of Angiotensinogen to Angiotensins CPA3 ATP6AP2 AGT GZMH-1 ENPEP CTSG CPB1 CTSD ACE MME CMA1 CES1 REN ACE2 CTSZ CPB2 ANPEP RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development HES1 ABL1 ZNF521 WWTR1 YES1 CBFB SATB2 COL1A1 HDAC4 UCMA HEY1 MAF IHH HEY2 SP7 HDAC6 AR SRC YAP1-1 RBM14 SMAD1 SMAD4 SMAD6 MAPK1 RB1 MAPK3 GLI3 GLI2 HDAC3 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry TMPRSS2 ACE2 CTSV;CTSL VCP-1 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210747 Regulation of gene expression in early pancreatic precursor cells PTF1A HNF1B FGF10 ONECUT1 NKX6-1 PDX1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112315 Transmission across Chemical Synapses STX1A PRKAB2 CACNA2D2 BCHE SLC6A4 GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 SLC18A3 PRKAG2 PRKACA-1 SLC5A7 UNC13B RAB3A SYT1 PRKCA SYN3 CPLX1 SYN2 SYN1 RIMS1 PPFIA1 PRKAR2B PPFIA4 SLC18A2 PPFIA3 PPFIA2 RPS6KA3 RPS6KA2 KPNA2 RPS6KA1 HSPA8 PRKCB ARL6IP5 NAAA ADCY9 PRKAR1B PRKAR1A GRIN2A ADCY4 ADCY3 MYO6 GRIN2B ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A SNAP25 PDPK1 CAMK1 CAMKK1 CAMKK2 GNAT3 HRAS GNAI3 NRAS COMT PRKAA2 GRIA2 CALM3;CALM1 TSPOAP1 RPS6KA6 CHRNB2 ACTN2 CHRNA2-1 CASK CHRNA1 CHRNB4 CHRNA9 CHRNA3 LIN7A CHRNB3 LIN7C GRIN2C CHRNA5 GRIN2D CHRNA4 GRIN3B CHRNA6 GRIN3A GNAL SLC32A1 DLG2 SLC6A13 GNGT1 DLG3 ABAT NBEA GABRB3 SLC6A1 GABRB2 ALDH5A1 GABRB1 GRIK5 RASGRF1 GRIK3 GRIK4 GRIK1 GRIK2 PLCB3 NRGN GABRR3 GABRR2 GABRR1 GABRG3;GABRG2 PLCB1 PLCB2 NPTN NEFL SLC1A1 HTR3A HTR3B LRRC7 SLC1A2 SLC1A3 LIN7B CHRNA7;CHRFAM7A PPM1E PPM1F NCALD GLRA1 CHRND CACNB1 GLRA2 CACNB4 CACNA2D1 GLRA3 SLC1A6 CACNA2D3 CHRNG CHRNE CACNA1B SLC1A7 KCNJ2 KCNJ12;KCNJ18 KCNJ3 GABRQ SLC38A2 KCNJ4 GABRA2 GNG10 GABBR2 GABRA1 SLC38A1 GNG2 KCNJ5 GABBR1 GNG5 GNG4 KCNJ6 KCNJ10 GABRA6 GNG8 GABRA5 KCNJ9 GABRA4 GABRA3 KCNJ15 RASGRF2 KCNJ16 GRIN1 GLRB APBA1 GAD1 GAD2 GNG13 CACNB2 CACNB3 GNB2 GNB1 PRKCG GNB4 GNB3 GNB5 PRKAB1 SRC GNAI1 GNAI2 KIF17 PRKAG1 SLC22A2 GLS2 SLC22A1 RAC1 PRKAG3 NRG1 SLC17A7 CACNG8 CACNG2 CACNG3 CACNG4 AP2A1 VAMP2 GLUL GIT1 CACNA1A SLC6A12 SLC6A11 LRTOMT CACNA1E MAOA MDM2-2 CAMK4 GLS PRKAA1 CAMK2B CAMK2D CAMK2A AKAP5 SLC6A3 CAMK2G DNAJC5 CHAT DLG4 ACHE ALDH2 PRKX MAPK1 MAPK3 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation HSP90AB1 PPP1CA FURIN CSNK2A2 CSNK2A1;CSNK2A3 HSP90AA1 PPP1CC CSNK2B SPCS3 HSPA8 SPCS2 SPCS1 KPNB1 SEC11A SEC11C XPO1 PPP1CB SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste KCNJ2 OTOP1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P RPIA REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.7 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 GCKR NUP155 GCK NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 97%5659996 RPIA deficiency: failed conversion of R5P to RU5P RPIA TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis MEF2D MTERF1-1 HELZ2 TFB1M GABPA MED1 TFB2M PPRC1 NRF1 TFAM-1 HCFC1 POLRMT POLG2 TWNK PERM1 PPARGC1A PPARGC1B SSBP1 TGS1 CREBBP ATF2 RXRA CAMK4 ALAS1 CARM1 PPARA ESRRA NCOA1 NCOA2 NCOA6 SMARCD3 HDAC3 ATP5F1B CRTC1 ACSS2 NCOR1 NR1D1 CALM3;CALM1 SIRT4 SIRT5 IDH2 SIRT3 GLUD1;GLUD2 SOD2 CHD9 CYCS-1 TBL1XR1 MEF2C CRTC2 CRTC3 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs HPGD LTA4H PTGS2-2 ALOX5 ALOX15 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 97%437239 Recycling pathway of L1 SHTN1 NUMB EZR RPS6KA6 CLTC CLTA AP2A1 DPYSL2 AP2B1 RDX AP2A2 DNM1 MSN DNM2 DNM3 AP2S1 SH3GL2 L1CAM KIF4B;KIF4A RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK1 RPS6KA4 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 97%6807878 COPI-mediated anterograde transport COG4 COG3 COG2 DYNC1LI1 SPTBN2 KDELR1 BET1L DYNC1LI2 ANK2 GOLGB1 SPTBN4 ANK1 SPTBN5 GOSR2 DYNC1I1 CAPZA3 INS;INS-IGF2 ACTR10 CAPZB TMEM115 ARFGAP3 GOLGA2 COG1 ARFGAP2 DCTN6 DCTN5 DCTN4 ARF4-1 SPTA1 DCTN1 NSF TMED2-1 ANK3 RAB1A RAB1B CAPZA1 CAPZA2 ACTR1A STX5 YKT6 KDELR2 ARF1 COPB2 COPA COPE TMED3 TMED7 TMED9 COPZ2 GORASP1 COPZ1 NAPB ARF5 TMED10 SPTBN1 USO1 NAPG GBF1 DYNC1I2 ARCN1 DCTN2 COPG2 FOLR1 COPG1 DCTN3 BET1 COPB1 SPTAN1 NAPA CD59 CD55 SPTB GOSR1 ARFGAP1 DYNC1H1 COG8 COG7 COG6 KDELR3 COG5 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769726 Defects of Coagulation cascade GP1BA FGG ANO6 TPST2 F2 TPST1 F5 F8 VWF F9 F10 F11 GP5 GP9 PROC GGCX PROS1 FGB FGA GP1BB KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization KRT16;KRT14 KRT6B;KRT6C;KRT6A KRTAP1-5;KRTAP1-3;KRTAP1-1;KRTAP1-4 KRTAP26-1 KRTAP3-1 KRT10-2 KRTAP3-2;KRTAP3-3-1 KRTAP19-5 KRT4 KRT2 KRT8 KRT7 KRT5 KRT9 KRTAP13-1;KRTAP13-2 KRT24 KRT23 KRT20 KRT33A;KRT33B;KRT31-2 KRT28 KRT27 KRT26 KRT25 KRT32 KRT39 KRT36 KRT13 KRT12 KRT19 KRT18 KRT17 DSG2 KRT15 KRTAP24-1 KRT71 KRT79 KRT78 KRT77 KRT75 KRT74 KRT73 KRT72 KRT40 KRTAP11-1 KRT82 KRT80 KRT85 KRT84 DSP SPRR3 CSTA KLK5 PCSK6 EVPL KLK8 PPL LCE3E;LCE3D;LCE3B;LCE3C;LCE3A;LCE4A-1 TGM1 CASP14 DSG1 LIPJ PKP4 SPRR1A;SPRR1B LIPN LIPM PRSS8 LIPK KRT1 TGM5 ST14 CDSN PERP SPINK6 SPINK5 KLK13 KLK14 KAZN CELA2B;CELA2A LCE6A PKP2 PKP1 LORICRIN DSG3 PKP3 SPINK9 DSG4 DSC1 IVL DSC2 DSC3 CAPNS1 JUP CAPN1 FURIN KRTAP27-1 KRTAP16-1 KRT81;KRT83-1 KRTAP10-10;KRTAP10-2;KRTAP10-3;KRTAP10-11;KRTAP10-9-2 KRTAP4-3 KRTAP13-4;KRTAP23-1;KRTAP13-3-1 KRT3;KRT76 KRTAP29-1 KRTAP2-2;KRTAP2-1;KRTAP2-3;KRTAP2-4-2 KRTAP8-1 KRTAP9-4;KRTAP9-3;KRTAP9-8;KRTAP9-7;KRTAP9-6;KRTAP9-2;KRTAP9-9-1 KRTAP10-1;KRTAP10-12;KRTAP10-7;KRTAP10-6;KRTAP10-4 KRTAP10-8 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%211945 Phase I - Functionalization of compounds PTGIS MAOA NR1H4 MTARC1 FMO1 FMO2 AADAC ALDH1B1 FMO3 CYP26B1 PAOX CYP27B1 CYP26A1 ADH1C;ADH1B;ADH1A AHR PTGES3-1 CYP24A1 CYP2S1 AIP CYP7B1 CYP19A1 POMC TBXAS1 HSP90AB1 FDXR RXRA CYP1B1 CYP7A1 CYP4F22 CYP11B1;CYP11B2 CYP2C18-1 CBR3 CYP2J2-1 ARNT NCOA1 NCOA2 FDX1 CYP2B6 CYP2W1 CYB5R3 CYP8B1 ADH5 ADH4 ARNT2 NQO2 ACSS2 CYP46A1 ACSS1 BPHL CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP4B1 ALDH3A1 CYP21A2 CYP1A1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP51A1 CYP2E1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP11A1 EPHX1 CYP39A1 PTGS1 AHRR CES3 CES2 CMBL CES1 ALDH2 CYP27A1 CYP2F1 CYP2R1 CYP2A13;CYP2A6;CYP2A7-1 CYP4V2 POR CYP2U1 ALDH1A1 AOC3 MAOB AOC1 MTARC2 AOC2 SIGNALING BY RAF1 MUTANTS%REACTOME DATABASE ID RELEASE 97%9656223 Signaling by RAF1 mutants CAMK2G MARK3 ARAF CALM3;CALM1 RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 JAK2 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF MAPK3 KSR1 KSR2 CAMK2B CAMK2D CAMK2A RAP1B NRAS APBB1IP G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 97%392451 G beta:gamma signalling through PI3Kgamma GNB3 GNGT1 GNB5 GNG10 PDPK1 PIK3R6 GNG2 PIK3R5 GNG5 AKT2 GNG4 AKT3 GNG8 RHOA PIK3CG GNG13 GNB2 GNB1 AKT1 GNB4 HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 97%167169 HIV Transcription Elongation NCBP1 CCNT1 CDK7 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 NCBP2-1 TCEA1 ELL ELOC-1 ELOA NELFB ELOB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators COLEC10 C1S C1R FCN2;FCN1 MASP1 C1QC COLEC11 C1QB CRP MBL2-1 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 97%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER STX5 SEC24A AREG TGFA SEC24C MCFD2 SERPINA1 CTSC LMAN1L GOSR2 MIA2 MIA3 TMED10 LMAN2L SAR1B LMAN2 CTSZ COL7A1 CNIH1 CNIH2 FOLR1 CNIH3 SEC24D-1 F5 F8 GRIA1 CD59 TMED2-1 SEC22B SEC23A LMAN1 PREB SEC24B MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.6 Mitochondrial translation MRPS17 C12orf65 GFM1 MRPS15 MIEF1 MRPS16 MALSU1 MTFMT MRPS14 MRPS11 MTIF2 MRPS12 MTIF3 MRPL38 MRPS36 MTRES1 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 NDUFAB1 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 TUFM OXA1L GFM2 MTRF1 MTRF1L MRRF LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 97%9005891 Loss of function of MECP2 in Rett syndrome HDAC1 CALM3;CALM1 CAMK4 TBL1XR1 GPS2 NCOR2 NCOR1 SIN3A PRKACA-1 HDAC3 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX SIGNALING BY CSF3 (G-CSF)%REACTOME%R-HSA-9674555.4 Signaling by CSF3 (G-CSF) TYK2 PTPN11 UBE2D3-1 STAT3 CSF3 GAB2 KRAS GRB2 SHC1-1 JAK2 LYN SOCS1 UBE2D3;UBE2D2 UBA52 SOCS3 STAT1 UBE2D1 STAT5A STAT5B RPS27A SYK UBB;UBC HCK RNF7 ELOC-1 JAK1 ELOB CSF3R CUL5 FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 97%1566977 Fibronectin matrix formation ITGB1 ITGA5 FN1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 97%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 97%8957322 Metabolism of steroids SLC10A1 NR1H4 SLC10A2 MED1 TM7SF2 NSDHL STARD3 STARD4 STARD5 STARD6 SAR1B CREBBP CH25H POMC INSIG2 INSIG1 SREBF1 AKR1B1 SREBF2 ARV1 OSBPL9 GPAM OSBPL7 OSBPL6 HSD17B3 OSBPL3 HSD17B4 OSBPL2 DHCR24 HSD17B7 STARD3NL ALB NFYA-1 DHCR7 CYP17A1 RAN LGMN HSD17B1 AKR1D1 HSD11B1 HSD17B2 HSD11B2 NCOA1 NCOA2 NCOA6 CYP8B1 LBR GGPS1 TSPO CYP46A1 MSMO1 ACACB ACACA CYP21A2 CYP51A1 ELOVL6 EBP CYP11A1 FDPS SEC24D-1 CHD9 ABCB11 CYP27A1 PLPP6 SLC51A GC SLC51B TBL1XR1 FASN HSD3B1;HSD3B2 MVD LHB HELZ2 FABP6 SLC27A2 CYP27B1 SLC27A5 AKR1B15;AKR1B10 MVK HMGCS1-1 MBTPS1 OSBP ACOX2 CYP24A1 SCAP MBTPS2 PIAS4 KPNB1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 UBE2I STAR CYP7B1 CYP19A1 VDR ACAT2 TGS1 HSD3B7 SP1 PMVK SRD5A2 FDXR SRD5A1 SRD5A3 RXRA OSBPL1A CYP7A1 SUMO2 CYP11B1;CYP11B2 SLCO1A2 CARM1 PPARA CUBN ACOT8 SEC23A NFYB NFYC FDX1 SMARCD3 SEC24B SEC24A SEC24C CGA IDI1 FDFT1 IDI2 SQLE TSPOAP1 HSD17B12 LRP2 HSD17B11 SERPINA6 SCD STS LDLRAP1 AMACR BAAT CYP39A1 MTF1 ABCD3 CYP2R1 LSS SC5D ABCC3 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins CDK1 BUB1B CDC20 FBXO5 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 AURKB PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 UBA52 CDC14A ANAPC15 ANAPC16 CUL1 UBE2D1 AURKA ANAPC10 CCNB1 ANAPC11 CDK2 PTTG1;PTTG2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 RB1 ANAPC1 ANAPC2 PLK1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 GNB3 GNGT1 GNB5 ARHGEF6 GNG10 GNG2 GNG5 GNG4 PAK1 GNG8 CDC42 GNG13 GNB2 GNB1 GNB4 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 97%8964539 Glutamate and glutamine metabolism GLUD1;GLUD2 RIMKLA KYAT1 RIMKLB GLS GOT2-1 OAT PYCR1 PYCR2 GLUL GLS2 PYCR3 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 97%196757 Metabolism of folate and pterines MTHFD2 SHMT2 SHMT1 ST20-MTHFS;MTHFS MTHFD1L SLC19A1 MTHFR SLC25A32 ALDH1L1 ALDH1L2 FOLR2 DHFR2;DHFR MTHFD2L SLC46A1 MTHFD1 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism HPRT1 PNP-1 APRT ADA DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 97%3656225 Defective CHST6 causes MCDC1 PRELP OMD ACAN KERA FMOD CHST6 LUM OGN MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system MRC1 UBB;UBC TLR2 B2M RPS27A UBA52 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SLC26A1 SLC35B3 SLC26A11 SLC35B2 PAPSS2 PAPSS1 SLC26A2 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) CYP2C9;CYP2C19 EPHX2 CYP2J2-1 CYP1A1 CYP1B1 CYP1A2 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.2 RHO GTPases Activate Formins SRGAP2 NUP133 NDC80 BUB1 RANGAP1 CLASP2 BUB1B CDC20 FMNL3 FMNL1 PPP1CC BUB3 FMNL2 MAD2L1 SPDL1 NUP43 RANBP2 EVL PFN2-1 SRF NSL1 RPS27 NUP37 MAPRE1-1 PPP2R1A KNL1 ZW10 RAC1 PFN1 RHOA DSN1 SCAI CKAP5 RCC2 ZWINT XPO1 AHCTF1 PAFAH1B1 DYNC1I2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E RHOC RHOD DYNC1H1 RHOB NDE1 PLK1 MRTFA DYNC1LI1 DYNC1LI2 KIF18A ITGB1 DAAM1 CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 ACTB-1 DYNC1I1 B9D2 SPC24 SPC25 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B ACTG1 INCENP CDC42 KNTC1 CENPA BIRC5 CENPE CENPC SGO1 SGO2 AURKB CENPS-CORT;CORT;CENPS CENPT NUP107 CENPU CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM DIAPH1 CENPO NUP160 CENPP NUP85 DIAPH3 CENPQ CLIP1 MAD1L1 ITGB3BP DVL1 DVL2 DVL3 SEC13 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 97%380270 Recruitment of mitotic centrosome proteins and complexes CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 TUBG2 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 MAPRE1-1 PRKACA-1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 CEP290 YWHAG CDK5RAP2 HSP90AA1 CEP135 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 CDK11A;CDK11B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ ALMS1 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) ISY1;ISY1-RAB43 RBX1 COPS4 COPS2 CDK7 MNAT1 POLR2A POLR2B POLD1 POLR2C POLR2D POLR2G ZNF830 POLR2I RFC5 TCEA1 RFC3 RFC4 RFC2 GPS1 GTF2H2C;GTF2H2C_2;GTF2H2 UVSSA ERCC8 POLR2E XAB2 LIG1 POLR2F POLR2H POLK POLE POLR2L RFC1 LIG3 ERCC3 PCNA UBA52 ERCC5;BIVM-ERCC5 PPIE ERCC2 DDB1 GTF2H1 GTF2H3 ERCC6 GTF2H4 RPA1 XPA RPA2 AQR COPS7B COPS7A POLD3 POLR2J;POLR2J2;POLR2J3 POLD4 PRPF19 POLD2 RPA3 RPS27A XRCC1 POLE4 CUL4A UBB;UBC COPS3 ELL COPS6 COPS5 ERCC4 POLE2 ERCC1 POLE3 COPS8 CCNH CUL4B USP7 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport LPL AKR1B15;AKR1B10 APOB APOA2 APOA1 APOA4 PNLIP LRP1 TTR LRAT BCO2 LRP2 BCO1 GPC1 LRP8 SDC4 GPC3 APOC3 SDC2 GPC2 RBP4 SDC3 GPC5 RBP2 GPC4 RBP1 HSPG2 APOC2 GPC6 RETSAT LRP10 RDH11 AGRN LRP12 SDC1 APOM LDLR PLB1 APOE CLPS GPIHBP1 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8931838 DAG1 glycosylations SLC35A1 SLC35A4 MGAT5B-1 FKRP B4GAT1 POMK CRPPA CHST10 DAG1 B3GALNT2-2 RXYLT1 LARGE1 LARGE2 POMGNT1 FKTN POMT2 POMGNT2 POMT1 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013423 RAC3 GTPase cycle ABL2 BCR SRGAP2 ITGB1 AMIGO2 NOXO1 PAK1 PGRMC2 NOXA1 ABR SNAP23 NCKAP1L PAK4 GIT2 MCAM CAV1 NOX3 MPP7 FERMT2 NOX1 JAG1 ESYT1 ARHGAP1 ARHGAP6 DSG2 EMD ARHGAP39 SYDE1 CDC42 ARHGAP42 CDC42EP1 VAMP3 SLITRK3 ARHGDIB PIK3R2 NHS SLITRK5 CYBB CYBA PIK3R1 WASF2 LMAN1 ARHGAP5 ARHGAP21 BAIAP2 LBR YKT6 ARHGAP17 ARHGAP15 BAIAP2L1 OPHN1 TMPO ARHGAP35 MCF2 LEMD3 VANGL1 ABI2 DEPDC1B GARRE1 TAOK3 OCRL RAB7A ARHGAP26 ABI1 EPHA2 ARHGAP32 PAK2 DIAPH3 TIAM1 NCF1 NCF2 DOCK10 NCF4 STBD1 RAC3 CYFIP1 GIT1 NCKAP1 SWAP70 WASF1-1 VRK2 TRIO TFRC ARAP2 LAMTOR1 ARAP3 ERBIN RAPGEF1 VAV2 PREX1 SLC1A5 RACGAP1 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 97%201688 WNT mediated activation of DVL PIP5K1B TPTEP2-CSNK1E;CSNK1E CSNK2A2 DVL1 CSNK2A1;CSNK2A3 DVL2 DVL3 CSNK2B DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9734009 Defective Intrinsic Pathway for Apoptosis JUN GOLGA2 CDK5R1 CDC25A CDC25B BCL2L11 APP SOD2 C1QBP FASLG FOXO3 CDK5 CDKN2A PRDX2 CAPNS1 TP53 CAPNS2 PRDX1 LMNB1 YWHAE CAPN2 CAPN1 CAST CDC25C TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNFRSF13C LTBR TRAF2 BIRC2 BIRC3 TRAF3 MAP3K14 CD40LG TNFRSF12A LTA TNFSF11 LTB TNFRSF11A TNFSF13B TNFSF14 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 97%5626978 TNFR1-mediated ceramide production SMPD3 SMPD2 TNF RACK1 TNFRSF1A NSMAF ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%9645460 ALPK1 signaling pathway TRAF6 TIFA UBB;UBC MAP3K7 TAB3 TAB2 ALPK1 RPS27A UBA52 TAB1 CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.4 Cell junction organization CSNK2A1;CSNK2A3 NECTIN2 MOGS RPN2 RPN1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 ITGB4 PSMD6 PSMB4 PSMD7 ILK PARVA PSMB5 TESK1 PSMB2 CLDN2 PIP5K1C PSMB3 PSMD2 ZC3H12A PCSK7 PSMD3 ANK3 CLDN6 CLDN4 PSMB1 PSMD1 CLDN3 CLDN9 CLDN8 JAK1 CLDN7 ADRM1 RSU1 CADM3 PSMC2-1 CADM1 CADM2 PSMA2-1 PARVB PSMA5 XIAP CLDN23-1 SEM1 LIMS4;LIMS1 PSMA6 CLDN20 PSMC5 TYK2 CLDN11 PSMA3 CLDN10 PSMC6 CTNND1 MTBP PSMA4 CLDN15 RACK1 CLDN14 DST CBLL1 CLDN12 PSMC3 PSMA1 CLDN19 EPS15 CLDN18 PSMC4 CLDN17 PSMC1 ITGA6 CTNNB1 BIRC2 CLDN16 FLNC ADAM33 PLEC CANX LIMS2 CD151 CDH9 CDH8 PCSK6 CDH7 CDH6 CDH3 TLE1 ADAM19 FBLIM1 CDH24 SDK1 SDK2 CLDN22;CLDN24-1 CDH10 UBA52 CDH12 CDH13 CDH17 CDH18 KDM1A CDH19 PARD6G NECTIN4 MPP5 NECTIN3 NECTIN1 RPS27A CRB3 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 STAT3 SNAI1 CLDN5 SNAI2 CDH1 JUP OST4 OSTC FERMT2 STT3A ANG JAK2 SP1 PRKCSH COL17A1 F11R DDOST PARD3 DAD1 CDC42 IL6ST LAMC2 GANAB CTSS FLNA FARP2 CTSB CTSV;CTSL IL6R LAMA3 FURIN LAMB3 CDH4 CTBP2 CDH2 CTBP1 RB1 CDH15 H2AC14 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A SEC11C SMARCA4 FOXA2 CDH5 H2AC20 H2AB2;H2AB3;H2AB1 SRC EZH2 TGIF2 PARD6B PARD6A PRKCI SPCS3 SPCS2 SPCS1 BANP SIRT1 ACTN1 RAC1 H2AJ TCF12 CLDN1 ANGPTL4 ELMO1 DOCK1 SUZ12 H2BC5 H2BC1 PXN SOX10 DNM2 MPHOSPH8 HEYL PRDM8 ILF3 FOXF1 BHLHE22 HOXC8 H2AC4 VAV2 HACE1 KMT5A ARHGEF4 ARHGEF6 ITGB1 MDM2-2 CTNNA1 KLF4 STRAP TWIST2 H2BC21 VCL RNF19B VASP EED WT1 H2AZ2;H2AZ1 ARID1A MYC HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 CDH11 AGO3;AGO1 ZNF217 TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 TIAM1 PVR RELA TRAF7 ZMYM2 NFKB1 IL6 MAPK1 POMT2 MAPK3 PATJ POMT1 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters SLC26A1 SLC26A3 SLC26A11 SLC26A7 SLC26A9 SLC26A6 SLC26A2 SLC26A4 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 97%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission DLG2 DLG3 DLG4 CAMK2G CAMK4 CAMK1 GRIN2A GRIN2B CALM3;CALM1 NEFL GRIN1 DLG1 LRRC7 ACTN2 PPM1E PPM1F CAMK2B GRIN2C CAMK2D GRIN2D CAMK2A DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 97%916853 Degradation of GABA ABAT ALDH5A1 INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling IL10RA TYK2 CXCL8 STAT3 TNFRSF1A TIMP1 IL10RB CSF3 FPR1 CD86 CXCL2;CXCL3;CXCL1-1 FCER2 CCL13;CCL2 CD80 CCL4L2;CCL4L1;CCL4 TNF CCL5 CCL19 IL1RN IL12B IL12A IL1R2 CCL3L1;CCL3L3;CCL3;CCL18 CCR1 CCL22 IL10 IL1R1 CCL20 LIF PTAFR CSF2 CXCL10 CSF1 IL18 IL1A IL1B PTGS2-2 CCR2 IL6 TNFRSF1B JAK1 CCR5 ICAM1 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) KCNK18-1 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer RBX1 CDK8 DLL4 PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 HDAC8 JAG1 ADAM10 HDAC9 NOTCH1 HDAC6 ADAM17 HDAC7 RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN NEURL1B MAML3 MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 UBA52 CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism ENTPD8 PNP-1 GDA SAMHD1 AGXT2 NT5C2 UPB1 ITPA DPYD NUDT5 TYMP NT5C NT5E DNPH1 NT5M NT5C1A NT5C1B;NT5C1B-RDH14 UPP1 ENTPD1 ENTPD2 XDH ENTPD3 DPYS NUDT16 ENTPD4 ADPRM NUDT15 ENTPD5 ENTPD6 ENTPD7 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 97%9824443 Parasitic Infection Pathways ARPC4 ARPC5 GNG10 GNG2 ARPC2 GNG5 ARPC3 GNG4 NOXA1 GNG8 YES1 CD163 PLK2 GNG13 NCK1 RHBDF2 MYH9 GNB2 ACTR2 GNB1 GNB4 GNB3 ITPR1 WNT5A ITPR2 GNB5 ITPR3 WASL MEFV NFKB2 PYCARD P2RX7 PSTPIP1 FZD7 CASP1 TXNIP SUGT1 GNAI1 PLCG1 GNAI2 WASF2 WASF3 BAIAP2 PRKACA-1 JUN RAC1 MYO10 BTK MYO5A MYO1C GGT1 DPEP2 DPEP1 ELMO1 ELMO2 CRK DOCK1 PTK2 GGT5 PRKAR2B CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 GSDMD VAV1 VAV2 MAPK14 MAPK8 ABL1 TXN GNAS-1 WAS NOXO1 ADCY9 PRKAR1B PRKAR1A ACTB-1 ADCY4 ADCY3 NLRP3 NCKAP1L ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 MYO9B PRKACB-1 NOX1 PRKAR2A ARPC1B ARPC1A ADAM17 HSP90AB1 NT5E ACTG1 C3AR1 CD3G IL18 CYSLTR1 IL1A CYSLTR2 IL1B CDC42 GNAT3 P2RX4 SYK FGR HCK ADORA2B GNAZ GNAI3 CYBA FCGR3A;FCGR3B FYN FCGR1A C3-1 NCKIPSD CTSG HMOX1 PLCG2 ABI2 CALM3;CALM1 ABI1 LYN IL10 GNGT1 ACTR3-1 FURIN RELA AHCYL1 NFKB1 IL6 PRKX MAPK1 MAPK3 ENTPD1 DVL1 ENTPD5 DVL2 DVL3 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 97%9841251 Mitochondrial unfolded protein response (UPRmt) HSPD1 SOD2 HSF1 DNAJA1-1 HTRA2 HSPE1 NRF1 FOXO3 CAT DEFA6;DEFA4;DEFA5 HSPA1A;HSPA1B HSPA9 LONP1 ATF5 ESR1 AKT1 SIRT3 TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 97%5655862 Translesion synthesis by POLK RPA1 RPA2 RPA3 RFC5 RPS27A RFC3 RFC4 RFC2 UBB;UBC POLK REV1 RFC1 MAD2L2 REV3L PCNA UBA52 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%191273 Cholesterol biosynthesis LBR MVD GGPS1 MVK IDI1 MSMO1 HMGCS1-1 FDFT1 IDI2 TM7SF2 NSDHL SQLE CYP51A1 ACAT2 EBP PMVK SREBF1 FDPS SREBF2 ARV1 HSD17B7 DHCR24 PLPP6 DHCR7 SC5D LSS CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import PXMP2 ABCD2 ATAD1 PEX16 FIS1 PEX2 PEX3 ABCD3 PEX11B PEX12 ABCD1 GDAP1 PEX13 PEX14 PEX26 PXMP4 PEX19 ACBD5-1 SLC25A17 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447043 Neurofascin interactions CNTNAP1 CNTN1 NFASC SDCBP ANK1 NRCAM DCX CELL DIVISION%REACTOME%R-HSA-68884.6 cell division STAG2 SMC1A NIPBL MAU2 KIF20A PDS5B PDS5A WAPL PLK1 SMC3 RAD21 KIF23 STAG1 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 97%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS2 PAPSS1 TXNRD1 SIGNALING BY NTRK1 (TRKA)%REACTOME DATABASE ID RELEASE 97%187037 Signaling by NTRK1 (TRKA) SOS1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 IRS2 SHC2 RALGDS ATF2 RALB MAPK13 RIT1 SGK1-1 RIT2 REST SRF JUNB PLCG1 ADORA2A PPP2R1A MAPK7 MAP2K5 TCF12 RHOA YWHAB CRK FOS NTRK1 CLTC CLTA AP2A1 AP2B1 NGF AP2A2 DNM1 DNM2 DNM3 AP2S1 MAPKAPK2 DNAL4 SH3GL2 ID1 PPP2CB;PPP2CA EP300 PPP2R5D ATF1 ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 RPS6KA1 MEF2A MAPK14 MEF2C MAPK11 MAPKAPK3 ADCYAP1 ADCYAP1R1 MEF2D EGR1 STAT3 CDK5 CHD4 SH3GL3 ID4 IRS1 PIK3R2 PIK3CB HRAS PIK3R1 JUND NRAS TPH1 FRS2 PIK3CA KIDINS220 FOSB SHC1-1 NTRK2 CDK5R1 F3 RALA-1 NAB1 NAB2 LYL1 ARC VGF TRIB1 SHC3 RRAD ASCL1 EGR2 EGR3 EGR4 FOSL1 MAP2K2;MAP2K1 RAP1A ID3 RAPGEF1 CDK5R2 ID2-1 MAPK1 BRAF MAPK3 CRKL MAPK12 PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%389948 PD-1 signaling CSNK2A1;CSNK2A3 WWTR1 SPOP CD4 PRKAB2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RPN2 CREBBP RPN1 PSMD12 PSMD11 PSMD14 PSMD13 LCK LEF1 PRKAB1 H2AC20 PSMA7 NFKB2 PSMD8 H2AB2;H2AB3;H2AB1 EZH2 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 ASH2L PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 CSK PSMD1 MAGT1 JAK1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PRKAG2 PSMA5 SEM1 PSMA6 JUN PSMC5 PSMA3 PSMC6 PSMA4 NEK2 MIB2 BTRC NFE2L2 PSMC3 PSMA1 TEAD1 YWHAG PSMC4 PRKAG1 TEAD2 PSMC1 SKP1 TEAD3 CTNNB1 H2AJ TCF7 PRKAG3 TEAD4 TCF7L1 FOS SUZ12 H2BC5 UBA52 EPAS1 H2BC1 ERLIN1 ERLIN2 STAT1 CUL1 CDK4 ATF3 EP300 PDCD1LG2 VCP-1 RPS27A TUSC3 DERL2 H2AC4 RNF5 UBB;UBC OS9 RNF185 KMT2A KMT2C TMEM258 RBX1 STAT3 GSK3B OST4 DERL3 DERL1 DPY30 OSTC STT3A STT3B H2BC21 HLA-DPB1-1 WDR5 HLA-DQB2;HLA-DQB1 CD3E CD3D HLA-DPA1 IRF1 EED DDOST HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 H2AZ2;H2AZ1 HLA-DRA CD3G DAD1 ERLEC1 CD274 B3GNT3 HIF1A PRKAA1 CUL3 MYC JUND MYCN PTPN11 PTPN6 TNRC6C MOV10 CSNK2A2 TNRC6A-1 PDCD1 AGO4 PRKAA2 RBBP4 AGO2 RBBP5 BRD4 AGO3;AGO1 FOSB TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 CSNK2B RBBP7 H2BC15;H2BC3;H2BC11;H2BC12 RELA YAP1-1 TCF7L2 NFKB1 COPS5 H2AC14 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 97%5679096 Defective ABCG5 causes sitosterolemia ABCG5 ABCG8 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME DATABASE ID RELEASE 97%9758890 Transport of RCbl within the body TCN2 CD320 TCN1 LDLRAP1 LRP2 ABCD4 LMBRD1 ABCC1 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation LIG4 XRCC6 XRCC4 XRCC5 PSIP1 BANF1 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 97%4793952 Defective MGAT2 causes CDG-2a MGAT2 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 97%9769739 Regulation of clotting cascade ANO6 ANO5 SMPD1 SERPINE2 GPC1 SDC4 PROS1 GPC3 SERPINA5 SDC2 THBD GPC2 SDC3 GPC5 CD177 GPC4 GP1BB F2R GP1BA HSPG2 GPC6 F2 F3 F5 APP F7 PROCR ADAMTS13 F8 VWF F9 SERPING1 SERPINC1 KNG1 SERPIND1 AGRN PF4;PF4V1-1 F10 F12 F11 GP5 SDC1 GP9 PROC SERPINE1 KLKB1 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 97%8849932 Synaptic adhesion-like molecules FLOT2 RTN3 DLG3 DLG4 FLOT1 GRIA1 GRIN2A GRIA3 LRFN3 GRIA4 LRFN2 GRIN2B PTPRF LRFN4 GRIN1 DLG1 LRFN1 PTPRD GRIN2C GRIN2D PTPRS ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.11 Antiviral mechanism by IFN-stimulated genes RPS14 RPS17 NUP133 RPS16 RPS19 RPS18 NUP50 GBP2;GBP3;GBP1 POM121;POM121C NUP54 RPS11 RPS10 RPS13 RPS12 EIF3C;EIF3CL NUP42 EIF1AY;EIF1AX NCK1 EIF3M EIF3K NUP43 EIF3L EIF3I EIF3J EIF3G SFN DUS2 RAE1 EIF3H RANBP2 EIF3E SNCA EIF3F EIF3D EIF3A DNAJC3-1 EIF3B PGGT1B FAAP24 RPS25 LOC105377022;FANCB RPS27 CASP1 FAAP100 RPS29 RPS20 CENPX NUP35 FANCM RPS21 FANCL RPS24 FANCA RPS23 PLCG1 FANCE FANCG IFIT1 FANCF IFIT3 JAK1 IFIT2 NUP37 TARBP2 PRKRA PPP2R1A MX1-1 FNTB;CHURC1-FNTB HSPA1L SKP1 CHUK UBA7 DDX58 ISG15 UBE2L6 HERC5 RPS27L ILF2 IKBKB RPS15A TRIM25 ARIH1 HSPA1A;HSPA1B IKBKG RPS3 IFIT5 UBA52 RPS2 NUP214 STAT1 CUL1 PPP2CB;PPP2CA OASL OAS1 ILF3 OAS3 FAU PIM1 PPP2R5A KPNA7 KPNA5 RPS27A KPNA3 PPP2R1B KPNA2 UBB;UBC RPS9 HSPA8 RPS7 RPS8 RPS5 RNASEL RPS6 ADAR EIF4G1 FLNB RPSA PPM1B CDK1 PTPN2 STAT3 EIF4A3 NPM1-2 MAP2K6 ACTB-1 FANCC KPNB1 NEDD4 UBE2I MAVS HSPA2 UBE2N PIN1 RPS4X SUMO1 RPS3A KPNA4-1 ACTG1 IRF3 GBP7;GBP4 TP53 BECN1 FNTA EIF4A2 EIF4A1 CENPS-CORT;CORT;CENPS FLNA USP18;USP41 NUP107 NUP188 EIF4E2 PDE12 KPNA1 EIF2S2 EIF4E EIF2S3;EIF2S3B NUP210 DHX9 EIF2S1 NUP93 NUP205 EIF4G3 EIF4G2 ABCE1 AAAS EIF4E3 NUP160 NUP85 TPR NUP88 NUP155 FURIN NUP153 UBE2E1 SPHK1 EIF2AK2 NUP62 MAPK3 GBP5-1 NDC1 RPS15 SEC13 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 97%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha RBX1 HIF3A PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 HIF1A ADRM1 PSMC2-1 VHL PSMA2-1 PSMA5 CUL2 LIMD1 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 UBE2D3-1 PSMC3 PSMA1 PSMC4 PSMC1 AJUBA UBE2D3;UBE2D2 UBA52 EPAS1 UBE2D1 EGLN1 EGLN3 EGLN2 RPS27A WTIP UBB;UBC ELOC-1 ELOB DEFECTIVE MMACHC CAUSES MAHCC%REACTOME%R-HSA-3359474.4 Defective MMACHC causes MAHCC MMACHC RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation NCBP1 EAF1 EAF2 CTR9 RTF1 CDK7 CTDP1 PAF1 MNAT1 POLR2A SUPT6H POLR2B POLR2C POLR2D AFF4 POLR2G POLR2I MLLT1 MLLT3 IWS1 SSRP1 NCBP2-1 TCEA1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNK CCNT1 CDC73 SUPT16H POLR2E LEO1 POLR2F GTF2F1 POLR2H GTF2F2 POLR2L ERCC3 ERCC2 GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 ELL ELOC-1 WDR61 ELOA NELFB ELOB CCNH NELFCD NELFA NELFE XAV939 STABILIZES AXIN%REACTOME%R-HSA-5545619.4 XAV939 stabilizes AXIN TNKS TNKS2 PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation NBEA ADCY9 PRKAR2B PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKACA-1 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%438064 Post NMDA receptor activation events PRKAR1B PRKAR1A GRIN2A RASGRF2 GRIN2B GRIN1 ADCY1 ADCY8 PRKAB2 PRKACB-1 PRKAR2A CAMK4 PRKAB1 PDPK1 CAMK1 SRC CAMKK1 GRIA1 CAMKK2 DLG1 HRAS PRKAA1 CAMK2B CAMK2D CAMK2A PRKAG2 NRAS PRKACA-1 CAMK2G PRKAA2 PRKAG1 GRIA2 RAC1 PRKAG3 NRG1 CALM3;CALM1 RPS6KA6 ACTN2 GRIN2C GRIN2D DLG2 DLG3 DLG4 RASGRF1 PRKAR2B GIT1 NRGN RPS6KA3 RPS6KA2 NEFL KPNA2 RPS6KA1 LRRC7 PRKX MAPK1 MAPK3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69473 G2 M DNA damage checkpoint CDK1 BLM CCNA2-1 CCNA1 PIAS4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 UBE2N H2BC21 RAD9B KAT5 CHEK2 CHEK1 SFN RAD9A HUS1 YWHAQ EXO1 YWHAH TOPBP1 DNA2 RHNO1 RFC5 RFC3 RFC4 RFC2 TP53 YWHAE ATRIP WEE1 UBE2V2 BARD1 RBBP8 RAD17 ATM TP53BP1 RAD50 ATR YWHAG BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 BABAM1 BABAM2 RMI2 UIMC1 YWHAB RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 WRN H2BC1 YWHAZ RPA1 HERC2 RPA2 CCNB1 NSD2 RPA3 RAD1 BRIP1 MRE11 NBN CDC25C DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 97%5083627 Defective LARGE causes MDDGA6 and MDDGB6 B4GAT1 LARGE1 METHIONINE SALVAGE PATHWAY%REACTOME%R-HSA-1237112.4 Methionine salvage pathway ADI1 MRI1 GOT1-1 MTAP ENOPH1 APIP THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME DATABASE ID RELEASE 97%164952 The role of Nef in HIV-1 replication and disease pathogenesis CD28 ARF1 RAC1 B2M ATP6V1H HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CD4 ELMO1 AP2A1 PAK2 AP2B1 AP2A2 AP1G1 AP1S2 LCK CD8B;CD8B2 AP1S1 AP2S1 AP1S3 AP1B1 DOCK2 HCK PACS1 AP1M2 FYN AP1M1 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 97%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ABL1 PIAS4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I MDC1 UBE2N KDM4A H2BC21 KDM4B EYA1 KAT5 CHEK2 SMARCA5 SUMO1 PHF6 TP53 UBE2V2 BARD1 ATM TP53BP1 RAD50 BAZ1B BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 BABAM1 BABAM2 UIMC1 ABRAXAS1 UBXN1 RNF8 BRCC3 APBB1 H2BC15;H2BC3;H2BC11;H2BC12 EYA2 H2BC5 EYA3 EYA4 BAP1 UBA52 PPP5C H2BC1 HERC2 NSD2 RPS27A UBB;UBC MRE11 NBN MAPK8 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 97%2187335 The retinoid cycle in cones (daylight vision) OPN1MW3;OPN1MW2;OPN1MW;OPN1LW AWAT2 OPN1SW DHRS3 RLBP1 RBP3 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 97%9761174 Formation of intermediate mesoderm OSR1 PAX2 BMP4 FOXC2 FOXC1 PAX8 LHX1 FGF2 MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205647 Mitophagy TBK1 ULK1 UBE2V1 UBE2D3-1 CSNK2A2 PRKN CSNK2A1;CSNK2A3 OPTN-1 CSNK2B MAP1LC3B2;MAP1LC3B-1 SQSTM1 UBE2N UBE2D3;UBE2D2 UBA52 TOMM20 TOMM22 VDAC2-1 MAP1LC3A RPS27A FUNDC1 MFN1 ATG9A MFN2 ATG12-1 UBB;UBC VDAC3 TOMM40 PINK1 ATG5 MTERF3 TOMM7 VDAC1 TOMM70 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling PLA2G4A GNA13 AKT2 AKT3 MGLL TAS2R3-1 PDE3B TAS2R16 DRD1 DRD3 DRD4 DRD5 POMC TAS2R40 TAS2R41 APP TAS2R39 ADORA2A EGFR ADORA3 ADORA1 PRKACA-1 PPP2R1A PRKCE TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 PRKAR2B PRH1-TAS2R14;TAS2R14-3 RPS6KA3 KPNA2 RPS6KA2 RPS6KA1 TIAM2 PDE1B PDE1A PDE2A PDE11A PDE10A LHB TAS2R7 TAS2R8 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW GRM4 TAS2R1 TAS2R4 PDPK1 CAMKK1 CAMKK2 C3AR1 TAS1R2 TAS1R1 CDC42 TAS1R3 CALM3;CALM1 MMP3 GNAL GNGT1 NBEA RGS9 ITGA5 RGS6 RGS7 GLP1R SST GNA14 GNG10 RAMP2 GABBR2 GNA15 GNG2 GABBR1 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ GNB2 GNB1 ADM IAPP GNB4 CHRM2 GNB3 CHRM4 ADRB1 ADRB2 GNB5 HTR4 RGS11 HTR6 HTR7 HRH2 CALCRL HRH4 HTR1E TAAR8 TAAR9 MCHR1 HTR1F TAAR6 HTR1D TAAR5 HTR1B TAAR2 HTR5A TAAR1 ADRB3 SCT RXFP4 RXFP1 MAPK7 RXFP2 RXFP3 GPR176 AGTR2 FPR1 SSTR3 GHRHR GALR3 GALR2 GALR1 NPBWR1 RHOA NPBWR2 GPR15 GPR183 PNOC MC4R GPR18 GPR27 EDNRB GPR25 HBEGF RHO GPR20 PTH1R EDN1 EDN3 GPR37 GPR32 PTH2R RGR MC3R GPR45 MC1R MC5R NPFFR2 GPR150 NPFFR1 P2RY12 NPFF HCRT P2RY13 PF4;PF4V1-1 P2RY14 QRFPR QRFP GPR55 HCRTR2 SCTR HCRTR1 ADM2 MTNR1A MTNR1B GPR83 GPR84 CALCB;CALCA RLN3 INSL3 INSL5 P2RY4 ADCYAP1 APLN ADCYAP1R1 VIPR1 VIPR2 RRH PTGDR GPR37L1 TAS2R42 ADRA2B GIPR CRHR1 PENK PPY CDK5 PPP1R1B CRH PDE3A PTGDR2 NPY4R2;NPY4R PPP3CC OXGR1 GPBAR1 GAL OPRD1 PTGER4 NPB RAMP3 PTH PTGER2 PTGER3 NPW RLN2;RLN1 GHRH HCAR1 HCAR2;HCAR3 RAMP1 NPY2R NPY RGS8 CAMK4 PDE8B PDE8A NPY1R PCP2 APLNR SUCNR1 GRK3 CALCR GRK6 PIK3CG OPN3 OXTR PDE4D-1 RGSL1 GRPR OPN5 TRPC7 EDNRA PYY PROK2 GPSM1 PROK1 GPSM2 TRPC6 UTS2R PRKCH TRPC3 TRHR GRM3 OPRM1 UTS2B HEBP1 CAMK2B AGTR1 GRM2 CAMK2D PTGFR CAMK2A LPAR1 GRM7 LPAR2 GRM6 CXCL12 LPAR3 GPER1 FPR2 LPAR4 GRM8 CAMK2G NTSR1 PDE4A NTSR2 GPSM3 GPR17 PTGIR NMB NPY5R XCR1 PDE4C OPRK1 XCL1;XCL2 GLP2R NMBR SSTR1 LPAR5 SSTR2 LPAR6 NMS SSTR4 NMU SSTR5 GNRH1 RGS14 MLN OPRL1 BRS3 PTHLH GPRC6A CNR2 GPR132 CNR1 CCKAR RGS20 GNRHR S1PR3 PRKCQ FFAR4 RGS22 FFAR2 S1PR2 GAST S1PR5 GPR39 RASGRP2 S1PR4 EDN2 RASGRP1 RGS10 ANXA1 RGS12 TACR2 PDE7B TACR3 TACR1 VIP CCKBR PDE7A NPSR1 GRP F2R TIAM1 PTGER1 F2 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 KNG1 F2RL1 F2RL2 CCR6 F2RL3 DGKG DGKE CHRM1 AHCYL1 DGKD CCR2 GPR68 DGKB GPR65 DGKA PRKX MAPK1 CHRM5 PMCH MAPK3 ABHD12 RGS4 RGS5 RGS2 RGS3 RGS1 GHSR CASR DGKZ SOS1 LTB4R2 DGKQ DGKK DGKI DGKH PIK3R3 ABHD6 PIK3R6 NTS PIK3R5 MCHR2 HRH1 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2A TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 DAGLB RGS18 RGS17 RGS19 RGS13 CALCA RGS16 P2RY6 P2RY2 P2RY1 RGS21 CCK KISS1 FFAR3;GPR42 PDE1C GRK2 GIP ROCK1 GCGR PPP1CA PLEKHG5 AKT1 PRKCD PRKCA C5AR1 C5 TRIO ITSN1 PREX1 PRKCB NGEF GNAS-1 ADCY9 PRKAR1B PRKAR1A ABR ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A ADRA1D ADRA1B ADRA1A TBXA2R GNA12 FSHB ARHGEF33 ARHGEF37 ARHGEF38 CRHR2 CYSLTR1 CYSLTR2 GNAT3 ADORA2B GNAZ HRAS GNAI3 FGD1 FGD2 FGD3 OPN1SW FGD4 NRAS C3-1 SAA2;SAA1 MCF2 MC2R ARRB1 PLCB3 PLCB4 PLCB1 PLCB2 CCR5 AGT CHRM3 PLXNB1 AVPR2 RASGRF2 CXCR4 GNAT2 PLEKHG2 PRKCG ITPR1 ITPR2 ITPR3 PPP3R1 SOS2 ROCK2 SRC PSAP ARRB2 PPP3CA PPP3CB GNAI1 GNAI2 GCG CXCL9 ADRA2C CXCL8 CXCL13 ADRA2A CX3CL1 CCR9 CXCL5;CXCL6 CCR8 CCR7 BTK CCR4 CCR3 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 KALRN CXCR1 CXCR3 CCL5 CXCR2 CCL1 CCL19 CCR10 CCL16 CCR1 NET1 CCL25 CCL21 CCL20 PPBP CXCL10 CXCL11 AKAP13 CCL28 CCL27 ACKR3-2 PPP2CB;PPP2CA VAV3 PPP2R5D LHCGR PPP2R1B FSHR GPHA2 RHOC TSHR GPHB5 VAV1 VAV2 RHOB ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 ARHGEF7 ARHGEF5 GNAT1 ITGB1 ARHGEF6 PAK1 PDYN FFAR1 PIK3R2 ARHGEF40 PIK3R1 CENPS-CORT;CORT;CENPS ARHGEF26 ARHGEF25 PIK3CA CGA ECT2 ARHGEF39 CX3CR1 ARHGEF10L MCF2L ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 AVPR1B ARHGEF19 ARHGEF18 AVPR1A AVP TSHB LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis LALBA B4GALT1 SLC2A1 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975578 Reactions specific to the complex N-glycan synthesis pathway MAN2A1 MGAT2 LHB MAN2A2 FUT6;FUT5;FUT3 CHST8 CHST10 CGA FUT8 FUCA1 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 97%156588 Glucuronidation SLC35D1 UGT1A1;UGT1A6 ABHD10 SLC35D2 UGP2 UGT2A1 UGDH UXS1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation AKT2 AKT3 CSNK2A1;CSNK2A3 BMI1 RING1 ATF2 HDAC5 PSMD12 RNF2 PSMD11 PSMD14 HDAC7 PSMD13 REST CBX8 RRAGA PSMA7 RRAGC CBX6 PSMD8 RRAGB PHC2 PHC1 RRAGD EZH2 PSMB6 CBX4 PSMB7 PSMD6 CBX2 PSMB4 PSMD7 PSMB5 PHC3 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 JUN PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 RPTOR MBD3 SUZ12 AKT1 UBA52 KDM1A GATAD2B GATAD2A RPS27A LAMTOR2 LAMTOR1 UBB;UBC LAMTOR4 LAMTOR3 LAMTOR5 PREX2 USP7 EGR1 SNAI1 SNAI2 SLC38A9 RCOR1 ATN1 SALL4 MAF1 MECOM NEDD4 RHEB CHD4 CHD3 TRIM27 USP13 TNKS TNKS2 RNF146 FRK OTUD3 EED PTEN MLST8 PPARG TP53 NR2E1 HDAC2 HDAC3 HDAC1 PML MTOR TNRC6C MOV10 MTA1 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 WWP2 TNRC6B CSNK2B RBBP7 MTA2 MTA3 MKRN1 MAPK1 MAPK3 STUB1 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 97%114608 Platelet degranulation TTN-1 CAP1 VEGFA CD109 RAB27B APP TLN1 ISLR HABP4 CHID1 PSAP GTPBP2 SYTL4 TAGLN2 NHLRC2 TEX264 SERPINE1 LY6G6F;LY6G6F-LY6G6D ALB EGF ENDOD1 APOH PECAM1 SPARC VTI1B MANF CALU CD36 MAGED2 FERMT3 ECM1 OLA1 PCDH7 CTSW TIMP3 HGF ANXA5 TOR4A SPP2 VEGFB VEGFC VEGFD AHSG LHFPL2 PCYOX1L FAM3C ACTN1 LEFTY2;LEFTY1 APLP2 TMX3 APOA1 SELENOP SCG3 PFN1 HSPA5 RARRES2 CYRIB SCCPDH LAMP2 LGALS3BP WDR1 PLEK PHACTR2 SRGN ITIH4 ITIH3 CLEC3B CDC37L1 TUBA4A BRPF3-1 STXBP2 PPBP ITGA2B VWF ABCC4 PF4;PF4V1-1 TGFB2 TGFB3 MMRN1 CYB5R1 TF PDGFB APOOL SELP ORM2;ORM1 QSOX1 CD63 ACTN4 VCL IGF2 A1BG FN1 IGF1 SERPINA3 PPIA A2M SERPINF2 ALDOA HRG THBS1 FLNA CFD TIMP1 SERPINA1 TGFB1 CALM3;CALM1 ACTN2 ITGB3 PROS1 F13A1 CFL1 FGB FGA FGG F5 PLG F8 SOD1 SERPING1 CLU KNG1 CD9 GAS6 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production IRF7 NFKB1 MYD88 RELA NFKB2 DHX36 DHX9 INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 97%162592 Integration of provirus LIG4 XRCC6 XRCC4 XRCC5 PSIP1 BANF1 KPNA1 PPIA NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 97%9034013 NTF3 activates NTRK3 signaling NTF3 NTRK3 SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 97%9842663 Signaling by LTK SOS1 PIK3CA IRS1 GRB2 PIK3R2 LTK PIK3CB TNK2 PIK3R1 ALKAL2 ALKAL1 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM SLC34A2 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9613829 Chaperone Mediated Autophagy HDAC6 HSP90AB1 IFT88 CETN1 EEF1A1 PLIN3 HSP90AA1 HBD;HBB RNASE1 RPS27A CFTR GFAP PCNT LAMP2 ARL13B UBB;UBC HSPA8 PLIN2 PARK7 UBA52 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358752 CTNNB1 T41 mutants aren't phosphorylated PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 97%1296052 Ca activated K+ channels KCNMB1 KCNMB2 KCNMA1 KCNMB3 KCNMB4 KCNN1 KCNN3 KCNN2 KCNN4 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes MAFK NFE2L2 ABCG2 ABCF2-H2BE1;ABCF2 CREBBP ABCC3 EP300 ABCC1 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9603381 Activated NTRK3 signals through PI3K PIK3CA IRS1 NTF3 PIK3R1 SRC NTRK3 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 97%6785807 Interleukin-4 and Interleukin-13 signaling MCL1 S1PR1 VIM FOXO1-1 TNF CEBPD IL4R MUC1 VEGFA IL13 VCAM1 LCN2 IRF4 ITGB2 SOCS1 POMC STAT6 POU2F1 OSM BATF IL4 JUNB CD36 JAK1 HGF TYK2 CXCL8 CDKN1A HSP90AA1 CCL13;CCL2 CCL11 IL13RA2 IL13RA1 FOS SOX2 AKT1 CCL22 SOCS3 LIF ITGAX STAT1 LBP IL17F PIM1 ITGAM IL17A HSPA8 TNFRSF1B ZEB1 HSP90B1 NANOG;NANOGP8 RHOU FSCN1 MAOA ITGB1 STAT3 BCL2 GATA3 BCL2L1 FGF2 FCER2 COL1A2 OPRD1 BCL6 JAK2 RORA IL23R IL23A FN1 IL18 IL1A IL1B TP53 PIK3R1 BIRC5 RORC IL2RG HIF1A OPRM1 SOCS5 MYC JAK3 NDN SAA2;SAA1 HMOX1 TIMP1 FASLG FOXO3 TGFB1 CCND1 ALOX15 MMP1 NOS2 MMP2 MMP3 MMP9 ALOX5 F13A1 ANXA1 IL12B IL12A IL6R IL10 LAMA5 PTGS2-2 IL6 ICAM1 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 97%5633231 Defective ALG14 causes ALG14-CMS ALG14 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 97%9959399 SLC-mediated transport of oligopeptides CTNS SLC15A1 SLC15A3 SLC15A4 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 97%446353 Cell-extracellular matrix interactions LIMS4;LIMS1 FLNA ITGB1 ARHGEF6 ACTN1 VASP FLNC LIMS2 ILK PARVA TESK1 FBLIM1 RSU1 FERMT2 PARVB PXN ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 97%936837 Ion transport by P-type ATPases ATP10D ATP1A4 ATP1A3 ATP10B ATP1A2 PDZD11 ATP10A ATP1A1 ATP2C2 ATP2C1 ATP9B ATP9A ATP1B3-1 ATP13A1 FXYD2;FXYD6-FXYD2 ATP13A4 ATP13A5 ATP13A2 CAMK2B CAMK2D ATP8A2 CAMK2A ATP8A1 ATP12A CAMK2G ATP11C ATP11B ATP2B4 ATP2A3 ATP1B2 ATP11A ATP2B3 ATP2A2 ATP1B1 ATP2B2 ATP2A1 ATP2B1 SRI CALM3;CALM1 ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP7A ATP4B ATP4A FXYD4 FXYD3 FXYD1 FXYD6 CUTC ATP7B REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 97%9617629 Regulation of FOXO transcriptional activity by acetylation FOXO1-1 TXN SIRT1 KAT2B CREBBP FOXO4 EP300 FOXO3 TXNIP SIRT3 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9614399 Regulation of localization of FOXO transcription factors FOXO1-1 SFN YWHAZ YWHAQ YWHAB YWHAG AKT2 AKT3 FOXO4 FOXO3 AKT1 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 97%3134975 Regulation of innate immune responses to cytosolic DNA TBK1 TRIM56 STING1 TRIM21 IRF3 RPS27A UBB;UBC NLRP4 TREX1 DDX41 TRIM32 ZBP1 UBA52 DTX4 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 97%428930 Thromboxane signalling through TP receptor GNB3 AAMP GNGT1 TBXA2R GNA13 GNB5 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ GNB2 GNB1 GNB4 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 CBL UBB;UBC DOK1 PTK6 AKT1 RPS27A UBA52 ARAP1 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.4 Neuropilin interactions with VEGF and VEGFR FLT1 NRP2 NRP1 KDR DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 97%9656249 Defective Base Excision Repair Associated with OGG1 OGG1 MITOCHONDRIAL MRNA MODIFICATION%REACTOME%R-HSA-9937008.1 Mitochondrial mRNA modification RPUSD4 RPUSD3 TRUB2 MTERF3 MTPAP RCC1L NGRN TRMT61B SLIRP LRPPRC FASTKD2 ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 97%9914355 Isovaleric acidemia IVD SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis DLD OGDH MRPS36 DLST HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%3214842 HDMs demethylate histones KDM4D KDM1A KDM6A KDM4C-1 JMJD6 RIOX2 KDM5A KDM1B KDM5B KDM5C PHF2 KDM6B H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KDM7A KDM3A PHF8 KDM3B KDM2A KDM2B KDM4A KDM4B ARID5B TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 97%168138 Toll Like Receptor 9 (TLR9) Cascade DUSP4 DUSP3 VRK3 DUSP6 DUSP7 ATF2 PIK3R4 APP NFKB2 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK TLR7 FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B EEA1 RPS6KA5 TASL RPS6KA2 IRF5 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 RBSN TRAF6 IRF7 TP53 PIK3C3 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 TICAM2 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 TICAM1 TLR9 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 NFKBIA RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 SLC15A4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%420092 Glucagon-type ligand receptors ADCYAP1R1 SCT VIPR1 VIPR2 GNG10 GNAS-1 GIPR GNG2 GLP2R GNG5 GNG4 GHRHR GNG8 GNG13 GNB2 GNB1 VIP GNB4 GNB3 GNGT1 GHRH GNB5 GIP GLP1R SCTR GCGR GCG ADCYAP1 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 97%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 BUB1B CDC23 CDC20 CDC26 CDC27 ANAPC7 BUB3 UBE2C MAD2L1 UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109581 Apoptosis UACA GZMH;GZMB-1 AKT2 AKT3 VIM SATB1 PSMD12 PSMD11 PSMD14 SFN TP63 PSMD13 DSG2 PPP3R1 PSMA7 PSMD8 GSDME PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 TFDP1 PSMD3 TFDP2 PSMB1 PSMD1 TP53BP2 YWHAE ADRM1 ROCK1 PSMC2-1 E2F1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PSMC5 PSMA3 PSMC6 DSP PSMA4 TP73 PSMC3 PSMA1 YWHAG PSMC4 PSMC1 BIRC2 CTNNB1 PLEC OCLN-1 YWHAB DSG1 PTK2 AKT1 UBA52 PRKCD YWHAZ TJP1 C1QBP DAPK1-1 DAPK2 DAPK3 PKP1 SPTAN1 APPL1 DSG3 CYCS-1 RPS27A APC ADD1 UBB;UBC CLSPN AVEN GSDMD DBNL GSN DIABLO-1 STK24 CASP9 STK26 CASP7 GAS2 BAK1 MAPT MAPK8 BCL2L11 BAD STAT3 BCL2 PMAIP1 BMF BID BBC3 BCL2L1 UNC5A PPP3CC DCC UNC5B CDH1 BCAP31 KPNB1 DNM1L BMX TJP2 PPP1R13B YWHAQ YWHAH CASP6 APIP OPA1 APAF1 TP53 FNTA CASP3 BAX TICAM2 TRADD LY96 FASLG TRAF2 TICAM1 KPNA1 CASP8 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CD14 FADD HMGB1-1 TLR4 PRKCQ LMNB1 DFFB DFFA HMGB2 PAK2 H1-0 H1-3 H1-2 H1-5 H1-4 ACIN1 MAGED1 NMT1 CDKN2A ARHGAP10 MAPK1 MAPK3 OMA1 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%947581 Molybdenum cofactor biosynthesis MOCS2 GPHN MOCS3 MOCOS FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes HDAC1 FOXO4 FOXO3 ATXN3 ABCA6 FOXO1-1 INS;INS-IGF2 FBXO32 PPARGC1A G6PC1 NR3C1 SIN3A SIRT3 POMC SREBF1 SMAD2;SMAD3 TRIM63 NPY GCK SOD2 IGFBP1 AGRP SMAD4 CAT RETN PCK1 PLXNA4 HDAC2 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9831926 Nephron development WNT9B HNF1B DLL1 POU3F3 HNF4A LFNG WNT4 IRX1 WT1 IRX2 LHX1 JAG1 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139915 Activation of PUMA and translocation to mitochondria TP53 TFDP1 TP63 PPP1R13B TFDP2 TP73 TP53BP2 BBC3 E2F1 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 97%9820448 Developmental Cell Lineages of the Exocrine Pancreas LAMA5 LAMA3 LAMA2 LAMA4 FN1 LAMB3 LAMB2 LAMB1 FGF2 FGF7 VTN LAMA1 EGF FGF10 LAMC3 LAMC2 LAMC1 FGF4 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RBX1 CDK8 DLL4 PSENEN NEURL1 HDAC11 HDAC4 CCNC-1 MIB1 HEY1 HEY2 CREBBP HDAC5 HDAC8 JAG1 ADAM10 HDAC9 NOTCH1 HDAC6 ADAM17 HDAC7 RBPJ DLL1 JAG2 PSEN1 MAML2 MAML1 NCSTN NEURL1B MAML3 MYC HDAC2 HDAC3 HDAC1 HES1 SNW1 MAMLD1 MIB2 HDAC10 NCOR2 SKP1 KAT2B KAT2A NCOR1 HES5 UBA52 CUL1 HEYL EP300 RPS27A PSEN2 UBB;UBC APH1A TBL1XR1 APH1B ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle UNC13B RAB3A SYT1 VAMP2 STX1A CPLX1 SNAP25 RIMS1 PPFIA1 PPFIA4 PPFIA3 PPFIA2 TSPOAP1 SLC5A7 CHAT SLC18A3 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid RARG PDK4 FABP5 ADH4 CYP26B1 CYP26A1 ADH1C;ADH1B;ADH1A RARB PDHB RXRG CRABP2 CRABP1 DHRS3 DHRS4 ALDH1A3 SDR16C5 DHRS9 ALDH1A2 RDH10 RDH14 DLD RDH13 PPARD ALDH8A1 RXRA DLAT RARA RDH11 PDK3 PDK2 PDK1 PDHX RDH5 PDHA1 RXRB ALDH1A1 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis DHRS7B FAR1 AWAT2 FAR2 AGPS GNPAT AWAT1 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 97%9675136 Diseases of DNA Double-Strand Break Repair RAD17 ATM RAD50 ATR BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN RAD9B KAT5 RAD51B RAD9A RAD51C RPA1 HUS1 RPA2 EXO1 BRCA2 RAD51AP1 TOPBP1 DNA2 RPA3 RHNO1 RFC5 RFC3 RAD1 RFC4 XRCC2 RFC2 PALB2 BRIP1 MRE11 ATRIP NBN BARD1 RBBP8 SEM1 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5658623 FGFRL1 modulation of FGFR1 signaling SPRED2 FGF23 FGF22 FGF3 SPRED1 FGF10 FGFRL1 FGF4 FGF2 FGF18 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 97%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction GJA1 MPP5 TJP1 PATJ CRB3 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling GAB1 PIK3CA NRG1 NRG2 EREG BTC EGF NRG3 ERBB2 NRG4 EGFR PIK3R1 HBEGF SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling SOS1 PRKCD PRKCA PTPN12 PRKCE NRG1 NRG2 EREG BTC EGF SHC1-1 NRG3 ERBB2 NRG4 EGFR HRAS HBEGF NRAS HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones MORF4L1-2 SAP130 SUPT7L KAT6A KAT6B MORF4L2 MBIP HAT1 KAT8 ENY2 TAF5L ATXN7 DR1 EP400 DMAP1 BRPF1 MRGBP YEATS2 ACTB-1 HCFC1 TADA3 TADA1 TAF9 VPS72 MSL2 OGT-1 H2BC18 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MSL1 CREBBP ATF2 H2BC21 KAT5 USP22 MSL3-1 WDR5 TADA2A ZZZ3 CLOCK TAF12 H2AC20 TAF10 PHF20 MEAF6 SGF29 NCOA1 NCOA2 ACTL6A TRRAP EPC1 SUPT20H KAT2B KAT2A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ING5 RBBP7 BRD1 TADA2B PAX3 H2BC15;H2BC3;H2BC11;H2BC12 KANSL1 ING4 BRPF3-1 H2BC5 ING3 MCRS1 KANSL2 H2BC1 KANSL3 SUPT3H TAF6L BRD8 ELP1 ELP2 EP300 ELP3 ELP4 ELP5 H2AC16;H2AC11 ELP6 H2AC4 JADE1 YEATS4 JADE3 JADE2 RUVBL2 RUVBL1 H2AC14 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 97%5387390 Hh mutants abrogate ligand secretion PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 DHH IHH UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 VCP-1 SHH PSMB4 RPS27A PSMD7 SYVN1 DERL2 ERLEC1 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 OS9 PSMD3 PSMB1 HHAT PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 97%6803211 TP53 Regulates Transcription of Death Receptors and Ligands TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TP53 TP63 PPP1R13B TP73 TP53BP2 TMEM219 IGFBP3 FAS INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109606 Intrinsic Pathway for Apoptosis UACA BCL2L11 GZMH;GZMB-1 BAD STAT3 BCL2 PMAIP1 AKT2 BMF AKT3 BID BBC3 BCL2L1 PPP3CC SFN TP63 PPP1R13B YWHAQ PPP3R1 YWHAH GSDME APIP APAF1 TP53 TFDP1 TFDP2 TP53BP2 YWHAE E2F1 XIAP CASP3 BAX TP73 YWHAG CASP8 YWHAB AKT1 YWHAZ C1QBP CYCS-1 NMT1 CDKN2A AVEN GSDMD DIABLO-1 CASP9 MAPK1 CASP7 BAK1 MAPK3 MAPK8 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 97%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 UBE2V1 IRAK1 IRAK2 TRAF6 MAP3K7 MAP2K4 IKBKG NOD1 NOD2 MAPK9 MAPK8 UBE2N TAB3 MAP2K7 RIPK2 MAPK10 TAB2 TAB1 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 SLC38A1 GLUL RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration AKT2 ITGA5 MMP13 AKT3 AKT1 CBFB ITGBL1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies BDH2 BDH1 HMGCS2 HMGCLL1 HMGCL AACS ACSS3 ACAT1 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 97%5638303 Inhibition of Signaling by Overexpressed EGFR EREG BTC EGF AREG TGFA EGFR HBEGF EPGN RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression SREBF1 HELZ2 RXRA MED1 NRIP1 CARM1 CHD9 PPARA EP300 NR1D1 NCOR1 CPT1A TBL1XR1 RORC PPARGC1A NCOA1 NCOA2 CREBBP TGS1 RORA NCOA6 SMARCD3 HDAC3 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802946 Signaling by moderate kinase activity BRAF mutants CAMK2G MARK3 MAP3K11 ARAF KRAS CALM3;CALM1 RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 PEBP1 JAK2 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF PHB MAPK3 KSR1 KSR2 CAMK2B CAMK2D BRAP CAMK2A RAP1B NRAS APBB1IP DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.3 Defective F8 accelerates dissociation of the A2 domain F8 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%R-HSA-3296469.6 Defects in cobalamin (B12) metabolism MTR-1 MMADHC MTRR MMAA ABCD4 MMAB MMUT CUBN TCN2 CD320 CBLIF LMBRD1 MMACHC AMN MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%5657655 MGMT-mediated DNA damage reversal MGMT ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) EPO PLCG1 EPOR IRS2 PLCG2 JAK2 LYN SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 97%201451 Signaling by BMP BMPR1B BMPR1A ACVRL1 BMP10 UBE2D3-1 BMPR2 CHRDL1 AMH NOG TGFBR3 GREM2 FSTL1 ACVR2B ACVR2A INHA UBE2D1 BMP2 AMHR2 CER1 SKI SMAD1 SMAD4 ZFYVE16 SMURF2 SMURF1 SMAD6 SMAD7 GDF2 SMAD9 INHBA SMAD5 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 97%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal NUP133 DYNC1LI1 DYNC1LI2 KIF18A BUB1 NDC80 RANGAP1 CLASP2 CENPN-2 MIS12-1 BUB1B CDCA8 CDC20 SKA1 PPP1CC SKA2 BUB3 MAD2L1 DYNC1I1 SPDL1 NUP43 B9D2 SPC24 SPC25 RANBP2 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP NSL1 RPS27 KNTC1 CENPA BIRC5 CENPE CENPC SGO1 NUP37 SGO2 AURKB CENPS-CORT;CORT;CENPS MAPRE1-1 PPP2R1A CENPT NUP107 CENPU KNL1 ZW10 CENPF CENPH CENPI TAOK1 DSN1 CENPK CENPL CKAP5 CENPM RCC2 ZWINT XPO1 CENPO NUP160 CENPP AHCTF1 PAFAH1B1 NUP85 CENPQ DYNC1I2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E CLIP1 MAD1L1 DYNC1H1 NDE1 ITGB3BP PLK1 SEC13 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9865118 Diseases of branched-chain amino acid catabolism DLD MCCC2 ECHS1 IVD MCCC1 BCKDHA PPM1K DBT BCKDHB BCKDK HIBCH ACAT1 AUH RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-HSA-8934903.5 Receptor Mediated Mitophagy ATG12-1 MAP1LC3B2;MAP1LC3B-1 ULK1 ATG5 CSNK2A2 CSNK2A1;CSNK2A3 MAP1LC3A FUNDC1 CSNK2B SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%9649948 Signaling downstream of RAS mutants CAMK2G MARK3 MAP3K11 ARAF KRAS CALM3;CALM1 RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 PEBP1 JAK2 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF PHB MAPK3 KSR1 KSR2 CAMK2B CAMK2D BRAP CAMK2A RAP1B NRAS APBB1IP BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%73884 Base Excision Repair ACD TINF2 TERF2 POT1 TERF2IP TERF1-1 PARG PNKP POLB MBD4 SMUG1 NEIL2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 APEX1 ADPRS POLD1 H2BC21 PARP1 NEIL3 NEIL1 H2AC20 NTHL1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 RFC5 RFC3 RFC4 RFC2 MPG OGG1 H2AJ TDG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LIG1 POLE RFC1 PARP2 H2BC15;H2BC3;H2BC11;H2BC12 LIG3 H2BC5 PCNA H2BC1 RPA1 RPA2 POLD3 POLD4 POLD2 RPA3 XRCC1 POLE4 FEN1 H2AC4 POLE2 POLE3 H2AC14 NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%164944 Nef and signal transduction HCK LCK ELMO1 FYN RAC1 DOCK2 PAK2 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones FKBP14 CXXC1 MYDGF TATDN2 PDIA6 YIF1A PDIA5 HDGF KLHDC3 ERN1 SRPRA HSPA5 SEC31A GOSR2 SHC1-1 TSPYL2 DDX11 ATP6V0D1 ZBTB17 SSR1 DNAJB11 GSK3A TLN1 DNAJC3-1 EXTL1 ACADVL DCTN1 WFS1 PPP2R5B EXTL2 TPP1 HYOU1 SYVN1 LMNA EDEM1-1 ADD1 WIPI1 CTDSP2 EXTL3 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ARFGAP1 DNAJB9 GFPT1 SRPRB-1 CUL7 JMJD7-PLA2G4B;PLA2G4B PREB KDELR3 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters ABCB10 ABCB6 ABCB7 ABCB8 TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 97%382551 Transport of small molecules ABCG5 ADD3 NR1H3 ABCC5 STOM ABCC6 ABCC9 SLC4A7 SLC26A11 RAB11FIP2 MYO5B SLC12A2 SAR1B SLC12A4 SLC12A5 SLC12A7 SLC26A2 SLC6A4 SLC26A1 RHCG RHBG VDAC2-1 VDAC3 MAGT1 SLC2A8 PRKACA-1 ANO8 ANO9 ANO6 ANO4 ANO5 ANO2 APOA2 APOA1 SKP1 ANO3 APOA4 ANO1 APOA5 PCSK6 APOC3 MIP ANO10 AQP8 AQP10 AQP9 AQP6 UBA52 AQP11 AQP4 APOC2 AQP5 SLC35B3 AQP2 AQP3 SLC35B2 LOC100509620;LOC112267859;AQP7 CUL1 AQP1 PRKAR2B VCP-1 RPS27A SLC22A3 SLC22A8 TUSC3 UBB;UBC SLC22A4 CYB5R2 SLC22A5 CYB5R1 SLC35D1 CYB5R4 CYB5RL SLC35D2 SLC16A8 SLC16A3 CREB3L3 ABCA6 SLC14A1 SLC14A2 SLC47A1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC25A26 BSG SLC22A15 SLC22A16 HBD;HBB AKAP1 A2M SLC8A3 ATP2B4 ATP2A3 EIF2S2 ATP2B3 EIF2S3;EIF2S3B ATP2A2 ATP2B2 EIF2S1 ATP2A1 ATP2B1 SRI CALM3;CALM1 ATP6V1H SLC8A1 SLC8A2 GNGT1 FURIN LIPG LCAT APOBR SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC1A3 SLC3A1 SLC1A4 SLC7A11 SLC1A5 SLC6A20 SLC7A10 SLC1A6 SLC7A1 SLC1A7 SLC7A3 SLC25A29 SLC38A3 ARL2 SLC38A2 SLC38A5 SLC38A4 SLC36A1 GNG10 SLC6A19 SLC38A1 GNG2 SLC36A2 GNG5 SLC6A15 GNG4 SLC6A14 SLC16A10 GNG8 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC7A9 GNG13 GNB2 SLC5A8 GNB1 SGK1-1 GNB4 GNB3 GNB5 FBXL5 ABCB7 ABCB4 SLC5A5 SEL1L GPIHBP1 ABCA1 SLC24A5 ARF1 ANGPTL4 WWP1 SLC16A7 RAB11A EMB ABCD2 ABCC10 ABCC4 PEX3 ABCG4 ABCB5 ABCB8 ABCB9 ABCF1 ABCA2 ABCA5 ADD1 ABCA9 ABCA7 ABCA8 STEAP3 ABCB10 LETM1 LPL SLC24A2 SLC9A1 SLC24A3 SLC8B1 SLC4A8 AHCYL2 SLC4A9 SLC4A10 SLC4A2 SLC4A3 SLC4A5 SLCO1A2 ABCD1 TRPM1 TRPM2 TRPM7 TRPM8 ABCB1 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 SLC2A9 TRPC3 TRPA1 TRPC4 SLC25A18 CAMK2B TRPC1 CAMK2D TRPV2 CAMK2A TRPV3 SLC25A10 TRPV1 MCOLN1 SLC25A4 TRPC4AP SLC25A11 MCOLN2 MRS2 CAMK2G SLC66A1 TRPV6 TRPV4 ADD2 CAND1 NIPAL4 TRPV5 PIP-1 ANKH NIPAL1 NIPAL2 NIPAL3 LRRC8C LRRC8D PCSK5 LMF2 LRRC8A LMF1 LRRC8B LIPC LRRC8E ANGPTL8 DMTN ANGPTL3 MMGT1 NIPA1 FGF21 CTNS NIPA2 AZGP1 SLC25A22 SLC2A4 ATP7A SLC11A1 PCSK9 LSR LIPA NCEH1 NPC1-1 SOAT1 SOAT2 NPC2 SLC34A2 SLC34A1 APOC1 MTTP APOC4 P4HB APOB PDZD11 LCN2 PSMD12 PSMD11 PSMD14 PSMD13 SLC35B4 LCN15 LCN12 PSMA7 APOD SLC35A2 PSMD8 SLC35A3 SLC33A1 PSMB6 SLC35C1 ARL2BP PSMB7 PSMD6 LCN1 APOF PSMB4 SLC27A6 PSMD7 SLC29A4 PSMB5 SLC28A2 PSMB2 SLC25A5 SLC29A1 PSMB3 PSMD2 SLC28A1 PSMD3 SLC29A3 PSMB1 SLC27A4 PSMD1 SLC29A2 SLC17A8 SLC28A3 SLC25A6 ADRM1 PSMC2-1 ATP8A2 PSMA2-1 PSMA5 ATP8A1 ATP12A SLC30A3 SEM1 PSMA6 BEST2 SLC30A2 SLC39A10 PSMC5 BEST3 PSMA3 SLC9C2 SLC30A1 SLC39A14 PSMC6 BEST1 PSMA4 BEST4 SLC39A6 SLC39A5 ATP6V1E1 PSMC3 SLC39A8 ATP6V1E2 PLEKHA8 PSMA1 SLC39A7 ATP6V1G1 PSMC4 SLC39A2 ATP6V1G2 PSMC1 SLC39A1 ATP11C SLC39A3 ATP11B ATP1B2 SLC5A6 ATP11A ATP1B1 SLC9B1 SLC9B2 SCNN1G CLCA4-1 SLC7A5 SCNN1D SCNN1B SCNN1A SLC5A7 RAF1 ATP6V0D1 SLC10A6 ATP6V0D2 ATP6V1A TTYH3 TTYH2 WNK4 NALCN ASIC4 SLC9A2 ASIC5 SLC9A3 CLCA2 SLC9A4 ATP6V0A2 SLC9A5 CLCA1 SLC9A6 ATP6V0A4 SLC9A7 ASIC2 SLC9A8 ATP6V1D SLC9A9 ASIC3 ATP6V1C1 ATP6V1F ATP6V0A1 ASIC1 ATP6V1C2 ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP4B TFRC ATP4A DERL2 FXYD4 FXYD3 RNF5 WNK1 FXYD1 OS9 SLC27A1 WNK3 FXYD6 SLC25A1 SLC22A6 CUTC SLC5A12 RYR1 STEAP4 SLCO2B1 RNF185 RYR2 HFE SLC16A2 TCIRG1 SLC22A17 SLC13A5 RYR3 GLRX3 TFR2 UNC80 SLC13A2 IREB2 SLC13A3 CLCNKA;CLCNKB ATP7B SLCO1C1 FTMT SLCO4A1 CYBRD1 CLIC2 TF ATP6V0B TSC22D3 TRDN ASPH ATP6V1B2 ATP6V0C SLC26A7 ATP6V1B1 SLC26A9 GNAS-1 STOML3 SLC26A6 ATP10D ADCY9 ATP1A4 ATP1A3 CYGB PRKAR1B ATP10B PRKAR1A ATP1A2 ATP10A ATP1A1 MBTPS1 ATP2C2 ADCY4 ATP2C1 ADCY3 CLCN3 CLCN2 MBTPS2 ADCY2 CLCN1 ADCY1 BSND ADCY8 SGK3;C8orf44-SGK3 ADCY7 ATP6V1G3 ADCY6 ATP9B ADCY5 ATP9A SLC5A9 PRKACB-1 ATP1B3-1 SLC30A10 ATP13A1 SLC5A4 FXYD2;FXYD6-FXYD2 PRKAR2A SLC2A11 TPCN2 SLC2A12 TPCN1 SLC13A1 CLCN7 SLC13A4 CLCN6 SLC5A10 CLCN5 ACO1 GLTP SLC30A8 CLCN4 ATP6V0E2;ATP6V0E1 SLC45A3 SLC30A5 OSTM1 MFSD4B-2 SLC20A1 FKBP1B SLC35A1 SLC31A1 ATP13A4 ESYT3 ATP13A5 ESYT2 ATP13A2 UNC79 SLC41A2 SLC41A1 SLC2A6 SLC2A7 CPTP CLN3 SLC50A1 CUBN SLCO4C1 SLC36A4 SLC6A7 PEX19 NEDD4L SLC2A13 SLC5A11 SLC5A3 SLC32A1 SLC6A13 FTH1 SLC6A1 LDLRAP1 MB NGB CES3 SLC4A1 SLC4A4 APOE FTL-1 SLC39A4 SLCO2A1 SLC26A4 SLC26A3 AVPR2 VLDLR SLC22A12 SLC22A18 ALB AMN SLC40A1 SLC22A2 HEPH SLC22A1 SLC6A9 SLC17A6 SLC17A7 KCNJ11 CFTR ABCB6 SLC5A2 CLTC SLC46A1 ABCA3 CLTA ABCA4 AP2A1 AP2B1 ERLIN1 ERLIN2 AP2A2 CP AP2S1 SLC16A1 SLC6A12 SLC6A11 CETP STOML2 VDAC1 MCUB SPG7 PHB ABCG1 MAIP1 PHB2 PARL AFG3L2 SMDT1 YME1L1 PMPCB SLC12A3 MICU3 PMPCA SLC12A1 MICU2 MICU1 MCU CA1 SLC12A6 CA2 CA4 DERL3 DERL1 SLC3A2 NR1H2 SLC5A1-1 ESYT1 MYLIP ERLEC1 HBA2;HBA1 ABCA12 SLC6A5 SLC6A2 SLC6A3 SLC2A10 HMOX1 HMOX2 RHAG RUNX1 ABCG2 SLC24A1 SLC24A4 SLC11A2 ABCD3 ATP6AP1 SLC44A5 SLC2A1 SLC2A2 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC17A5 SLC15A1 AVP LDLR SLC15A3 SLC20A2 SLC15A4 RSC1A1 ZDHHC8 HDLBP ABCC3 ABCC1 ABCG8 ABCC2 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 97%72165 U12 Dependent Splicing NCBP1 SNRPF SNRPD2 SNRPD1 TXNL4A SNRPB SNRPD3 SRSF2 POLR2A POLR2B SRSF6 POLR2C SNRNP40 SRSF7 POLR2D POLR2G SRSF1 SNRPE-2 POLR2I DDX42 RNPC3 DDX23 NCBP2-1 YBX1 PDCD7 SNRPG-2 PRPF6 SNRNP35 PRPF8 SF3B4 SNRNP25 SF3B5 SF3B2 SF3B3 SF3B6 ZMAT5 POLR2E POLR2F GTF2F1 POLR2H GTF2F2 POLR2L SF3B1 ZRSR2-1 SNRNP48 POLR2J;POLR2J2;POLR2J3 SNRNP200 ZCRB1 EFTUD2 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 97%1912408 Pre-NOTCH Transcription and Translation JUN SNW1 MAMLD1 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 KAT2B AGO3;AGO1 H2AJ TNRC6B KAT2A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 RUNX1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 CREBBP H2BC5 H2BC21 H2BC1 NOTCH1 RBPJ H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 MAML2 EP300 MAML1 PRKCI H2AC4 SIRT6 TP53 ELANE TFDP1 ELF3 TFDP2 MAML3 NOTCH2 NOTCH3 NOTCH4 E2F1 E2F3 H2AC14 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764725 Negative Regulation of CDH1 Gene Transcription HDAC1 SIRT1 RBBP4 SNAI1 SNAI2 ZNF217 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 TCF12 RBBP7 TLE1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 TWIST2 SUZ12 H2BC5 H2BC21 H2BC1 KDM1A SMARCA4 H2AC20 EED MPHOSPH8 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 WT1 EZH2 TGIF2 ZMYM2 H2AC4 CTBP2 CTBP1 FOXQ1 DNTTIP1 MAPK1 ZBTB33 MAPK3 ZEB2 KMT5A PKM ZEB1 MCRIP1 HDAC2 H2AC14 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication HSP90AB1 HSP90AA1 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1QBP CDKN2A SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 97%2142688 Synthesis of 5-eicosatetraenoic acids GPX4 PON2 ALOX5AP PON1 ALOX5 LTC4S PON3 GPX1 G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase E2F2 CDK6 PPP2R1A ABL1 CDKN1A CDKN1B SKP1 CDK7 CCND1 MNAT1 CKS1B JAK2 CDKN2B LYN PPP2R3B CCND3 CCND2 UBA52 PPP2R2A;PPP2R2D CDKN2D CUL1 CDKN2C PTK6 CDK4 CDK2 PPP2CB;PPP2CA E2F4-1 RPS27A E2F5 CDKN2A PPP2R1B SKP2 UBB;UBC TFDP1 RBL2 TFDP2 RBL1 CCNE2 CCNE1 RB1 CCNH CDKN1C E2F1 E2F3 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis ST3GAL4 ST3GAL3 B3GALT4 ST6GALNAC6 B3GALT5 B3GALT2 B3GALT1 FUT2 FUT1 FUT4 FUT6;FUT5;FUT3 FUT7 B4GALNT2 FUT9 ST3GAL6 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373080 Class B 2 (Secretin family receptors) ADCYAP1R1 VIPR1 VIPR2 WNT9A RAMP2 GNG10 GNAS-1 GIPR GNG2 CRHR1 GNG5 SMO GNG4 GNG8 CRH WNT11 RAMP3 GNG13 PTH WNT4 IHH GNB2 GNB1 ADM PTCH1 IAPP GNB4 CALCA GNB3 WNT9B GHRH WNT5A RAMP1 GNB5 WNT1 FZD1 CALCRL FZD3 FZD2 GIP WNT6 FZD5 FZD4 CALCR FZD7 SHH FZD6 WNT2 FZD8 WNT3 PTCH2 WNT2B ADGRE1 ADGRE5 GCGR GCG SCT ADGRE3 FZD10 CRHBP GLP2R WNT16 GHRHR PTHLH WNT10B WNT10A FZD9 WNT3A DHH PTH1R UCN3 VIP GNGT1 PTH2R WNT8A WNT8B GLP1R CD55 WNT7B SCTR WNT7A ADM2 CALCB;CALCA ADCYAP1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%446203 Asparagine N-linked glycosylation COG4 COG3 DPM1 COG2 SPTBN2 DPM2 DPM3 BET1L B4GALT6 CTSC B4GALT4 B4GALT5 ST8SIA5 CAPZA3 ST6GAL1 CTSA ACTR10 MOGS RPN2 SAR1B RPN1 ST3GAL4 GOLGA2 DCTN6 ST3GAL1 DCTN5 ST3GAL2 DCTN4 ST3GAL3 EDEM2 SLC35C1 GRIA1 NSF ANK3 NAGK MAGT1 AMDHD2 GFPT2 GFPT1 PGM3 GNPNAT1 UAP1 RENBP ACTR1A AREG PSMC1 CANX CSNK1D MGAT5 MGAT1 COL7A1 UBA52 DYNC1I2 MGAT2 DCTN2 DCTN3 SEC24D-1 COPB1 MAN2A2 MGAT3 ST8SIA6 CHST8 ST8SIA2 FUCA1 EDEM3 ST8SIA3 VCP-1 CD59 RPS27A AMFR CD55 SYVN1 DERL2 TUSC3 EDEM1-1 UBB;UBC RNF5 RNF103 OS9 RNF139 TRIM13 DYNC1H1 UGGT2 UGGT1 RNF185 MARCHF6 TMEM258 DYNC1LI1 MVD DYNC1LI2 LHB ANK1 FUT8 MAN2A1 INS;INS-IGF2 OST4 CAPZB MAN1A2 MAN1C1 OSTC MAN1A1 STT3A CTSZ STT3B ST6GALNAC2 PRKCSH MGAT4A-1 SLC35A1 CHST10 DDOST DAD1 UMOD ASGR1 ASGR2 ST6GALNAC1 CMAS MANEA NPL MAN1B1 NANP ST6GALNAC3 NEU4 ST6GALNAC4 ST8SIA4 NANS SEC23A ST6GAL2 ST8SIA1 GNE CAPZA1 LMAN1 GANAB CAPZA2 SEC24B STX5 SEC24A YKT6 MGAT4C KDELR2 MGAT4B COPB2 COPA SEC24C ALG8 ALG9 COPE ALG6 MCFD2 ALG2 SERPINA1 ALG3 TMED3 PPP6C ALG1 TMED7 PPP6R1 PPP6R3 LMAN1L TMED9 COPZ2 GORASP1 COPZ1 SEC22A SEC22C NAPB ARF5 TMED10 STX17 LMAN2L UBXN1 USO1 NAPG NGLY1 MLEC LMAN2 SEC31B ENGASE ANKRD28 SEC23IP DHDDS CNIH1 CRYZL2P-SEC16B;SEC16B ARCN1 CNIH2 COPG2 FOLR1 COPG1 CNIH3 BET1 NAPA TFG HK1 SPTB NEU2 NEU3 ARFGAP1 NEU1 TRAPPC2L B4GALNT2 TBC1D20 PREB KDELR3 SEC13 ANK2 TGFA GOLGB1 SPTBN4 SPTBN5 TRAPPC3 TRAPPC1 GOSR2 TRAPPC4 TRAPPC5 TRAPPC9 ARFGAP3 COG1 ARFGAP2 ARF4-1 SPTA1 TRAPPC2;TRAPPC2B B4GALT1 TRAPPC6A TMED2-1 TRAPPC6B RAB1A RAB1B ALG14 ALG12 SEL1L ALG11 ST3GAL6 TRAPPC10 GLB1 ARF1 RFT1 SCFD1 SPTBN1 GBF1 PMM2 SPTAN1 CALR-1 KDELR1 SEC31A DYNC1I1 MIA2 MIA3 DERL1 DPAGT1 TMEM115 MPI DOLK SRD5A3 DCTN1 SEC22B ST6GALNAC5 ST6GALNAC6 ST3GAL5 CGA ALG5 NUDT14 MPDU1 FUT6;FUT5;FUT3 RAD23B F5 GMPPB FPGT GMPPA F8 GFUS DHRSX NUS1 B4GALT2 GMDS PMM1 B4GALT3 FCSK DOLPP1 ALG10;ALG10B GOSR1 SLC17A5 COG8 COG7 COG6 PDIA3 COG5 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%3769402 Deactivation of the beta-catenin transactivating complex HDAC1 BTRC RBBP5 AKT2 CTNNB1 TCF7 BCL9L SOX3 TLE4 TLE3 SOX6 TLE2 SOX7 TLE1 SOX4 TCF7L1 PYGO1 DPY30 SOX13 BCL9 SOX9 PYGO2 SOX2 CHD8 XPO1 AKT1 UBA52 SRY CTNNBIP1 LEF1 CBY1 YWHAZ WDR5 TCF7L2 RPS27A ASH2L MEN1 APC UBB;UBC CTBP1 KMT2B XIAP SOX17 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions IL11 CNTF LIF TYK2 CNTFR IL11RA CLCF1 LIFR IL31 OSM IL31RA OSMR IL6ST CRLF1 JAK1 CTF1 JAK2 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways ABCG5 NR1H3 MARK3 ADH1C;ADH1B;ADH1A DLL4 S1PR1 PPP1CC NEURL1 PDE3B IDE PTPRF SPOP CSNK1G2 DTX1 DTX2 DTX4 DNER DLK1 CNTN1 RAB4A PRKG2 LBR PDHB VAPB APOC2 PDK3 PDK2 PDK1 PDHX TIAM2 SPINT1 HPN MST1 LHB MST1R SPINT2 INS;INS-IGF2 MEMO1 ACBD5-1 LYPLA1-1 ZDHHC21 GLP1R DBT ALDH1A1 ULK1 NOS3 MTMR1 IQGAP1 MTMR4 ARF6 GGA3 ABCA1 MC4R EDNRB EDN1 EDN3 MC3R DLD MC1R MC5R ID1 NPFFR2 NPFFR1 NPFF HCRT QRFPR QRFP HCRTR2 HCRTR1 LETM1 FABP5 FABP6 FABP7 STK11 THEM4 PIK3CD PIK3CG OXTR RGSL1 GRPR EDNRA PROK2 PROK1 UTS2R PRKCH TRHR UTS2B AGTR1 PTGFR LPAR1 LPAR2 LPAR3 FPR2 LPAR4 NTSR1 NTSR2 GPR17 NMB XCR1 XCL1;XCL2 NMBR LPAR5 LPAR6 NMS NMU GNRH1 MLN BRS3 GPRC6A GPR132 CCKAR GNRHR FFAR4 FFAR2 GAST GPR39 EDN2 ANXA1 TACR2 TACR3 TACR1 CCKBR NPSR1 GRP PTGER1 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 F2RL1 F2RL2 F2RL3 DGKG DGKE AHCYL1 CHRM1 DGKD GPR68 DGKB GPR65 DGKA CHRM5 PMCH ABHD12 RGS4 RGS5 RGS2 RGS3 RGS1 GHSR CASR DGKZ LTB4R2 DGKQ DGKK DGKI PIK3R3 DGKH ABHD6 PIK3R6 NTS PIK3R5 MCHR2 HRH1 GRK5 TAC3 TAC1 OPN4 NMUR2 NMUR1 DAGLA MLNR HTR2B HTR2A TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 DAGLB RGS18 RGS17 RGL1 RGS19 RGS13 RGS16 P2RY6 P2RY2 P2RY1 WASL RGS21 CCK KISS1 FFAR3;GPR42 GIP LEP HHIP BOC GAS1 CDON NGFR RXRB PTPRK EPS15L1 EPN1 ADAM12 GCGR LRIG1 FAM83D AAMP PAG1 FAM83A SPRY1 PTPN3 PPP1CA ICMT TLE5 C5AR2 C5AR1 C5 CD55 NDUFS3 MEF2D ANOS1-1 GRAP2 FSHB PIP4K2A CRHR2 PIP4K2B PIP4K2C IGF1 PLCG2 PLCB3 PLCB4 FES PLCB1 PLCB2 MAPK12 USP8 PTPN18 MATK WNT9A SFRP1 SFRP2 WIF1 AGT SOST CHRM3 ITPR1 ITPR2 ITPR3 PSAP CXCL9 ADRA2C CXCL8 CXCL13 ADRA2A CX3CL1 CCRL2 CCR9 CXCL5;CXCL6 CCR8 CCR7 CCR4 CCR3 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 PTPN13 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 CCL5 CXCR2 CCL1 CCL19 CCL17 CCR10 CCL16 CCR1 CCL25 CCL22 CCL21 CCL20 PPBP CXCL10 MTR-1 CXCL11 ACKR4 ACKR2 CCL28 CCL27 ACKR3-2 LHCGR FSHR GPHA2 TSHR GPHB5 CETP ARL4C EEPD1 ABCG1 CHD8 IGF2 PDYN FFAR1 DLAT RANBP9 OCRL NAB1 NAB2 LYL1 ARC VGF ABCD3 TRIB1 RRAD ASCL1 EGR2 EGR3 EGR4 FOSL1 ID3 CDK5R2 ID2-1 TSHB SPTBN2 PTGES3-1 POMC APP RAP1B HGF DOCK7 GAB1 DNAJB1 MET AREG FGF7 FGFBP1 FGFBP3 FGF22 FGF3 FGF10 TCF7L1 WNT3A SOX2 MYB TSC2 TSC1 KDM1A DOCK10 DOCK11 KIF5B KIF5A KLC1 KLC4 KLC3 KLC2 RACGAP1 KIF18A RCOR1 ITGA2 DOCK6 DOCK5 DOCK4 DOCK3 DOCK9 DOCK8 CAPZB CRABP1 JAK2 DHRS3 DHRS4 ALDH1A3 SDR16C5 DHRS9 ALDH1A2 RDH10 RDH14 RDH13 ALDH8A1 KIF2A KIF2C KIF2B DOCK2 CDC42 MFN1 MFN2 SH2B3 SH2B2 CENPE HGS ATP6V1H RAB7A LMNB1 CFL1 PAK2 RALA-1 HNRNPF FLT4 SLC1A5 RAMP2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 MYH9 ATF2 ADM SGK1-1 KAT5 CHEK1 EPO PRKAB1 CDH5 RRAGA RRAGC CALCRL RRAGB RRAGD E2F4-1 MAPKAP1 CDKN1A PRKAG1 PRKAG3 RPTOR CASP10 RASGRP3 FOS PPP5C RICTOR LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 USP7 USP2 SOX17 CDC25C ADCYAP1 ADCYAP1R1 FLRT2 MAPKAPK5 FLRT3 FLRT1 MDM2-2 ADRA2B SLC38A9 WWC1 PBX1 DLGAP5 PTCRA ACTA2 FCER2 TACC3 LINGO1 MAG OMG RTN4 RHEB PIN1 PRR5 MLST8 CASP2 RBL1 BIRC5 PRKAA1 SOCS6 AURKB PML MTOR BAX HDAC10 TRRAP PCSK5 ANGPTL3 HGFAC KDM1B RUVBL1 KDM4C-1 KDM3A HDAC8 KDM4A KDM4B CALCA REST APOD RANBP10 DDX4 ROCK1 TNFAIP1 ARHGAP5 RND3 ARHGAP21 MUC13 FLOT2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST TMOD3 PLEKHG5 TXNL1 SCRIB SEMA4F LEMD3 CKAP4 KTN1 NISCH VANGL1 CCDC88A DEPDC1B VANGL2 UBXN11 CPD DLG5 KCTD13 DSG1 PKP4 RBMX EPHA2 PICALM KIT NTRK3 VWF ITSN2 CYFIP2 CYFIP1 NCKAP1 ANKLE2 WASF1-1 TRIO TFRC WIPF1 WIPF2 ITSN1 WIPF3 STMN2 EPOR FNBP1L MYLK PREX2 PREX1 WDR91 ANKFY1 CEP97 PRKCB FNBP1 STARD8 MRTFA BCR DYNC1LI1 DYNC1LI2 MYL6 WDR81 DAAM1 NGEF CENPN-2 MIS12-1 CDCA8 IQGAP2 IQGAP3 PRKCZ SKA1 SKA2 ABR RHOT1 MYO6 NCKAP1L STARD13 JUP MCAM FAM135A NOX3 HNRNPC FERMT2 NOX1 CDC42SE2 ARHGAP9 ARPC1B ARPC1A ARHGAP1 OSBPL11 ARHGAP6 LRRC1 ARHGAP4 NUF2 EMD NUDC RRAS2 GMIP LRRC41 CIT INCENP CDC42EP5 CDC42EP4 CDC42EP3 CDC42EP2 CDC42EP1 VAMP3 PKN3 GPS1 KCTD3-1 CENPA FGD1 CENPC FGD2 FGD3 LMAN1 NRTN FGD4 FGD5 NCAM1 CHN2 CHN1 FLNA PSPN STX5 GFRA2 GFRA4 YKT6 CENPT ARTN FARP2 FARP1 CENPU USP9X KIDINS220 MCF2 WWP2 DEF6 WDR11 TMEM59 CENPF CENPH ABI2 TAOK3 CENPI TAOK1 SHKBP1 CENPK ABI1 CENPL CENPM GOPC FILIP1 PKN2 CENPO PKN1 CENPP CENPQ UHRF1BP1L NCF1 FAM13B PLXND1 NCF2 NCF4 FAM13A MSI2 STK10 SLK TPM4 TPM3 RALGAPA1 SHC3 SWAP70 VRK2 FAM91A1 PTPRA TEX2 ARMCX3 SPTB CLIP1 PHIP MAD1L1 RHOBTB3 LIN7B RHOBTB1 RHOBTB2 STIP1 DDRGK1 DVL1 STK38 DVL2 DVL3 PLXNA1 ABL2 SRGAP3 SRGAP2 SRGAP1 ARPC4 ARPC5 NDC80 COPS4 NSFL1C ARPC2 ARPC3 COPS2 SPTBN4 NOXA1 SPTBN5 PLXNB1 NF2 MAP3K11 ZNF512B ACTC1;ACTG2 RASGRF2 SNAP23 NRP2 ARHGAP8;PRR5-ARHGAP8 TAGAP EFHD2 GFRA3 NCK2 SPDL1 NCK1 PLEKHG3 PLEKHG4 ACTR2 PLEKHG1 PLEKHG2 PLEKHG6 ARFGAP3 NIPSNAP2 ARFGAP2 LCK DSG2 SPTA1 EVL PPP1R12B PFN2-1 SOS2 ROCK2 SRC SRF ROPN1;ROPN1B NSL1 PARD6B PARD6A SH3BP1 ARL13B SLITRK3 LAMA1 NHS SLITRK5 CSK RBBP6 SPARC WHAMM WASF2 WASF3 RNF20 PPP1R14A PCDH7 CDC42BPB BAIAP2 PTPRS CDC42BPA MYO19 PRC1 CPNE8 GOLGA3 BAIAP2L2 BAIAP2L1 OPHN1 TMPO ACTN1 KNL1 ZW10 SPATA13 BTK PFN1 CFTR GRB7 TMEM87A GARRE1 TWF1 KALRN MYL12B DSN1 SCFD1 SPTBN1 SCAI RCC2 LAMC3 STAM ZWINT PTK2 NET1 ANLN AHCTF1 FAF2 KIF14 SH3RF1 AKAP12 ITGA3 AKAP13 HINT2 SH3PXD2A C1QBP STBD1 RAC3 LAMA2 SPTAN1 LAMA4 GIT1 NDEL1 LAMB2 VAV3 CCDC115 RALBP1-1 RHOG RHOH RHOF RHOC RHOD VAV1 VAV2 RHOB CTTN RHOJ ARHGEF3 ARHGEF4 ARHGEF1 RHOU TAX1BP3 ARHGEF2 RHOV ARHGEF7 DBN1 ARHGEF5 RHOQ ARHGEF6 GNAT1 AMIGO2 WAS NOXO1 TRAK1 TRAK2 PAK1 PGRMC2 SAMM50 EMC3 CTNNA1 PAK3 DYNC1I1 PAK5 PAK4 BCAP31 GIT2 HDAC4 CAVIN1 MTX1 MYO9B MYO9A MPP7 NR1H2 DLC1 TRIP10 NR3C1 RAB9A B9D2 ESR1 ESYT1 SPC24 RAB9B SPC25 TJP2 AR ERCC6L RXRA RTKN PRAG1 ZWILCH BUB1B-PAK6;PAK6 RARA ARHGDIG PGR ARHGAP39 PPARG PMF1;PMF1-BGLAP ACTG1 ARHGAP44 SYDE2 SYDE1 ARHGAP42 BASP1 TP53 ARHGDIA ARHGDIB KNTC1 ARHGEF40 CYBB CYBA ARHGAP45 SGO1 ALDH3A2 SGO2 STAM2 CENPS-CORT;CORT;CENPS ARHGEF26 ARHGEF25 ARHGEF28 ARHGAP19 ARHGAP18 ARHGAP17 ARHGAP15 TOR1AIP1 CSNK2A2 ARHGAP12 NCKIPSD ARHGAP22 ARHGAP20 MYH14 MYH11 RHPN2 ECT2 MYH10 CSNK2B CPSF7 ARHGEF39 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP26 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 DIAPH1 PLD1 ARHGAP32 DIAPH2 ARHGAP31 PLD2 ARHGAP30 DIAPH3 DNMBP DLG4 ACTR3-1 SOWAHC ARHGEF10L RND2 RND1 MCF2L FLOT1 ARHGEF11 ARHGEF10 ARHGEF12 ATP6AP1 ARHGEF15 ARHGEF17 ARHGEF16 ARAP2 ARHGEF19 ARHGEF18 ARAP3 SENP1 ARHGAP10 ZAP70 ALS2 PEAK1 PDE5A ITGB3BP CCDC187 RAP1GDS1 MOSPD2 ARHGAP11A-1 FAM169A ADD3 PLA2G4A UACA GNA13 TRA2B STOM PTK2B BUB1 CLASP2 SPEN LIMK2 LIMK1 CSNK2A1;CSNK2A3 HSPE1 MGLL FMNL3 SLC4A7 TAS2R3-1 FMNL1 FMNL2 VIM HDAC11 BMI1 TNF YY1 TAS2R16 RING1 CCL3L1;CCL3L3;CCL3;CCL18 HDAC5 HDAC9 RNF2 TAS2R40 HDAC6 TAS2R41 HDAC7 STAT6 CBX8 STAT5A STAT5B GPAM CBX6 PHC2 PHC1 POU2F1 CBX4 CBX2 TAS2R39 NFATC1 PHC3 EGF IL5 ERBB2 PLCG1 EGFR YWHAE CCP110 PPP1CB RNF31 MAPRE1-1 XIAP OTUD7B PRKACA-1 SPATA2 TNFAIP3 SHARPIN PPP2R1A USP21 USP4 MIB2 TNFRSF1A BTRC CYLD RBCK1 YWHAG OTUD1 BIRC2 SKP1 BIRC3 TCF7 HSP90AA1 CDC73 OPTN-1 TERT LEO1 PPP1R12A BCL9L TLE4 TLE3 TLE2 TLE1 AXIN2 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 PYGO1 BCL9 PYGO2 CKAP5 UBA52 PAFAH1B1 DYNC1I2 CUL1 PRH1-TAS2R14;TAS2R14-3 PRKAR2B ATF1 RPS27A ELK1 RPS6KA3 RPS6KA5 CLASP1 RPS6KA2 UBB;UBC RPS6KA1 OFD1-1 MEF2A DYNC1H1 MEF2C MAPKAPK3 NDE1 PLK1 MAPK8 TGIF1-1 CDK1 TPTEP2-CSNK1E;CSNK1E BCL2L11 TAS2R7 BAD STAT3 BCL2 TAS2R8 BCL2L1 GRM4 GRIN2B TAS2R1 CDH1 TAS2R4 COL1A2 HEY1 HEY2 ADAM10 ADAM17 PSEN1 SKI TAS1R2 TAS1R1 NCSTN TAS1R3 ELANE COL9A1 COL9A3 COL9A2 PLAT LAMC2 LAMC1 CASP3 DUSP5 TIMP2 DUSP2 KLK3;KLK2 DUSP1 TIMP1 PAQR3 PTPN7 CTSD FOXO4 FOXO3 PTPRJ MMP7 MMP2 MMP3 MMP9 MMP14 ZRANB1 MMP16 LAMA5 LAMA3 FURIN PLG PPM1A ITGA5 SPP1 YAP1-1 LAMB3 CMA1 E2F5 LAMB1 SST IL2RA STUB1 TRIM33 H2AC14 PDK4 TGFA MED1 WWTR1 YES1 FOXO1-1 RXRG CCNC-1 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SHC2 RALGDS CREBBP PTPRO IHH RALB CCND3 MAPK13 RIT1 RIT2 CHRM2 CHRM4 ADRB1 SMAD2;SMAD3 ADRB2 HTR4 SMARCA4 HTR6 HTR7 IL2 HRH3 IL3 H2AC20 HRH2 BMP2 H2AB2;H2AB3;H2AB1 HRH4 HTR1E TAAR8 EZH2 TGIF2 TAAR9 HTR1F TAAR6 HTR1D HTR1A ASH2L TAAR5 HTR1B TAAR2 SERPINE1 HTR5A JUNB TAAR1 RNF111 ADRB3 NCOA1 NCOA2 NCOA3 SCT RXFP4 MRGPRD RARG FZD10 RXFP1 RXFP2 RXFP3 UBE2D3-1 CRHBP RSPO3 GPR176 CMKLR1 NCOR2 AGTR2 KAT2B FPR1 H2AJ KAT2A GHRHR NR5A2 GALR3 TCF12 NCOR1 GALR2 GALR1 NPBWR1 RARB NPBWR2 WNT10B WNT10A GPR15 FZD9 GPR183 PLIN1 PNOC GPR18 GPS2 GPR27 MBD3 GPR25 CDKN2B GPR20 SUZ12 H2BC5 PTH1R UCN3 GPR37 WWP1 H2BC1 GPR35 GPR32 PTH2R RGR CSF2 PLPPR1 GATAD2B PLPPR2 ITGA2B GPR45 GATAD2A PLPPR3 PLPPR4 PLPPR5 WNT8A WNT8B GPR150 P2RY12 P2RY13 EP300 PF4;PF4V1-1 P2RY14 WNT7B GPR55 MEN1 SCTR WNT7A H2AC4 ADM2 MTNR1A MTNR1B GPR83 TBL1XR1 GPR84 CALCB;CALCA RLN3 ECE1 SKIL PRLHR DNMT1 INSL3 INSL5 KMT2B P2RY4 APLN ECE2;EEF1AKMT4-ECE2 VIPR1 VIPR2 ABL1 RRH PTGDR GPR37L1 KEL TAS2R42 GIPR CRHR1 NLN PENK CDK8 PPY PPP1R1B CDK5 CRH PDE3A ACTB-1 PTGDR2 NPY4R2;NPY4R PPP3CC OXGR1 GPBAR1 GSK3B GAL OPRD1 PTGER4 DPY30 NPB RAMP3 CHD4 SOX9 PTH CHD3 PTGER2 PTGER3 CITED1 NPW RLN2;RLN1 PRLH SIN3A PARP1 H2BC21 MAS1 XK GHRH RAMP1 NPY2R RGS8 NPY WDR5 CAMK4 PDE8B PDE8A NPY1R PCP2 TBP ATP1B4 EED APLNR SUCNR1 H2AZ2;H2AZ1 WNT6 KCTD6 GRK3 CALCR GRK6 SMAD1 WNT2 SMAD4 WNT3 SMURF2 OPN3 SMURF1 PDE4D-1 SMAD6 PTCH2 ESR2 OPN5 SMAD7 PYY NR4A1 GPSM1 GPSM2 WNT2B NR2E1 ADGRE1 YBX1 GRM3 OPRM1 HEBP1 CAMK2B GRM2 CAMK2D ADGRE5 HDAC2 CAMK2A GRM7 GRM6 HDAC3 THBS1 GPER1 ADGRE3 HDAC1 HES1 GRM8 CAMK2G PDE4A GPSM3 MTA1 PTGIR NPY5R RBBP4 PDE4C OPRK1 GLP2R SSTR1 RBBP5 SSTR2 WNT16 SSTR4 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 SSTR5 POLR2E RGS14 OPRL1 POLR2F PTHLH CNR2 POLR2H CNR1 RBBP7 MTA2 RGS20 MTA3 S1PR3 POLR2L RGS22 S1PR2 ITGB3 S1PR5 S1PR4 RGS10 H2BC15;H2BC3;H2BC11;H2BC12 RGS12 PDE7B ACKR1 VIP FGB FGA SCD PDE7A SRY F2R DISP2 FGG SCUBE2 F2 F3 NOTUM KNG1 CCR6 CCR2 PRKX S100A9 S100A8 IL2RB THBS2 PSMD12 GALNT3 NOTCH1 PSMD11 PSMD14 MUC20 PSMD13 LEF1 RBPJ TAX1BP1 DLL1 CAB39 PSMA7 PSMD8 LFNG PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 RAG2 PSMB3 RAG1 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 TEC SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 ATP6V1E1 ATP6V1E2 PSMC3 ATP6V1G1 PSMA1 ATP6V1G2 PSMC4 PSMC1 CTNNB1 IL5RA RAF1 RAB4B ATP6V0D1 ATP6V0D2 YWHAB ATP6V1A HSPB1 XPO1 AKT1 ATP6V0A2 PRKCD ATP6V0A4 PRKCA YWHAZ ATP6V1D ATP6V1C1 MAPKAPK2 ATP6V1F ATP6V0A1 ATP6V1C2 MAPK14 MAPK11 TCIRG1 EIF4G1 IFT172 GLI1 GLI3 GLI2 IFT52 IFT57 ATP6V0B DYNC2H1 IFT140 RPGRIP1L KIF7 ATP6V1B2 PTPN2 WDR35 ATP6V0C ATP6V1B1 RBX1 GNAS-1 IFT88 ADCY9 SMO PRKAR1B PRKAR1A GPR161 NUMB INTU ADCY4 ADCY3 TULP3 ADCY2 ADCY1 ADCY8 ATP6V1G3 ADCY7 ADCY6 ADCY5 PRKACB-1 KIF3A TTC21B PRKAR2A CSNK1A1 PTCH1 WDR19 IFT122 FUZ ATP6V0E2;ATP6V0E1 ADCY10 ITCH MKS1 CGN F11R FKBP1A PARD3 CYSLTR1 CYSLTR2 GNAT3 SYK SPRED3 SPRED2 RASA4;RASA4B ADORA2B SPRED1 SYNGAP1 GNAZ GNAI3 HRAS RASA3 FYN RASA1 RASA2 OPN1SW CUL3 MKNK1 RASAL1 RASAL2 SPRY2 RASAL3 NRAS DAB2IP NF1 KBTBD7 MYD88 C3-1 SAA2;SAA1 CCNK NUP107 CCNT1 IL3RA IRAK4 TLR9 GTF2F1 GTF2F2 TGFBR3 GIPC1 NEDD4L AAAS UHMK1 EPGN NUP160 NUP85 ARRB1 TRAF1 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 ABHD17C ABHD17B ABHD17A CDK9 POLR2J;POLR2J2;POLR2J3 RCE1 CCNT2-1 NELFB CCR5 SEC13 NCBP1 NUP133 RANGAP1 CSF2RB CSF2RA GTF2A1 GTF2A2 CXCR4 POLR2A IRS2 POLR2B POLR2C POLR2D SOCS1 NUP43 GNAT2 PRKCG POLR2G WNT5B POLR2I RYK-1 WNT5A ROR1 RANBP2 ROR2 NLK PPP3R1 WNT1 FZD1 FZD3 FZD2 FZD5 NCBP2-1 FZD4 FZD7 FZD6 FZD8 GNAO1 CLTB ARRB2 PPP3CA PPP3CB PRKG1 PRICKLE1 PDE6B PDE6A NUP37 CHUK IKBKB WDR83 IKBKG RGL3 FKBP5 RGL2 NTRK1 PEA15 CLTC IL17RD RAPGEF2 CLTA AP2A1 SEPTIN7 CDC14A AP2B1 CDC14B NGF RASGEF1A AP2A2 ETV4 DNM1 IGF2BP1 DNM2 DNM3 MAPK6 MAPK4 AP2S1 DNAL4 SH3GL2 AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C FRAT2 PPP2R1B APC PPP2R5E CDC37 ERBIN PHB ITGB1 RET GATA3 FGF2 WNT11 MECOM NEDD4 FGFRL1 WNT4 JAG1 WNT9B GFRA1 MYLIP GDNF ID4 ITGA8 ALK CD274 IRS1 PIK3R2 PIK3CB PTN PRDM1 PIK3R1 RNF41 IL2RG HIF1A PTPRZ1 MDK CUL5 MYC ALKAL2 ALKAL1 JAK3 FRS2 MYCN PIK3CA PTPN6 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 MKRN1 WWOX UBE2D1 RELA TCF7L2 NFKB1 IL6 GJA1 TBK1 AKT2 AKT3 DRD1 DRD2 DRD3 DRD4 PIK3R4 DRD5 ST3GAL4 SFN ST3GAL3 RPS27 DLG1 ADORA2A NRP1 ADORA3 ADORA1 IKBKE JAK1 PDGFRA TIAL1 FGF6 PTBP1 RBFOX2 PRMT1 RIPK2 ESRP2 HNRNPH1 ESRP1 HNRNPA1-1 TIA1 HNRNPM TYK2 CTNND1 RACK1 EPS15 PRKCE PCSK6 CFLAR GPC5 STAT1 TJP1 ZDHHC9 VCP-1 KPNA2 MAP3K7 EVC2 EFCAB7 CASP9 EVC GAS8 SPPL2B SPPL2A RPS6 CLIP3 NSMAF OTULIN PDE1B GOLGA7-1 TNS4 PDE1A TNS3 PDE2A PDE11A PDE10A DDX5 IRAK1 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW CAV1 SQSTM1 FLT3 TAB3 TAB2 TAB1 GSK3A TRIM27 HSP90AB1 USP13 TNKS TNKS2 YWHAQ RNF146 FRK YWHAH PDPK1 OTUD3 CAMKK1 CAMKK2 C3AR1 EEF2K TRAF6 PIK3C3 CAB39L STRADA VHL STRADB PTPN11 ATP2A3 EIF4E EIF4B ATP2A2 ATP2A1 CALM3;CALM1 ACTN2 GRIN2D GNAL DLG2 GNGT1 DLG3 NBEA GABRB3 THBS4 GABRB2 THBS3 PDGFD GABRB1 RASGRF1 RGS9 RGS6 RGS7 CCT2 GABRG3;GABRG2 NEFL SPHK1 LRRC7 CCNE1 GABRQ ARL2 ULK3 DZIP1 GNA14 SPOPL GABBR2 GNG10 GABRA1 GNA15 GNG2 GABBR1 GNG5 GNG4 GNA11 GNG8 CCT7 GRIN1 GNG13 CCT6A GNAQ GNB2 SNX3 GNB1 USP34 GNB4 IAPP GNB3 GNB5 RGS11 B4GALT1 POGLUT1 MCHR1 MAML2 MAML1 POFUT1 PRKCI TMED2-1 SIRT6 TFDP1 ELF3 TFDP2 MFNG MAML3 NOTCH2 NOTCH3 NOTCH4 SEL1L RFNG E2F1 E2F3 ST3GAL6 RAB6A JUN VEGFB SNW1 VEGFC MAMLD1 VEGFD MAPK7 MAP2K5 CDKN1B LRRK2 ARHGAP35 SFPQ-1 RAC1 SSTR3 PELP1 NRG1 NRG2 ARAP1 RHOA EREG BTC DOK1 NRG3 NRG4 ELMO1 ELMO2 CRK ZDHHC7 DOCK1 PDE6D CAV2 HBEGF RHO KHDRBS1 KHDRBS2 KHDRBS3 EPAS1 PXN CBL SOCS3 GPNMB STAP2 NTF3 PTPN1 SRMS PTK6 CDK4 CDK2 BCAR1 AMHR2 CER1 FST FOXH1 GFAP ZFYVE16 PSEN2 LTBP4 LTBP2 LTBP3 LTBP1 APH1A APH1B FASN TGFB2 TGFB3 GDF2 SMAD9 INHBB INHBA SMAD5 DRAP1 BAMBI MYF6 TCF4 BMPR1B MYF5 BMPR1A ACVRL1 BMP10 BMPR2 ITGB5 CHRDL1 ITGB8 PMEPA1 ITGAV ITGB6 AMH PSENEN MYOG HELLS SRRM1 NOG UCHL5 DDX39B KLF16 GREM2 MYOD1 STRAP PPP1R15A USP15 ACVR1B FSTL1 FSTL3 ACVR1C ACVR2B PGF ACVR2A FLT1 INHA SHB HCAR1 HCAR2;HCAR3 TRPC7 TRPC6 TRPC3 FOXA1 SMC3 FKBP4 RAD21 JUND GREB1 STAG1 CXCL12 STAG2 SMC1A TFF1 KANK1 CXXC5 TFF3-1 TRADD NRIP1 USF2 USF1 FASLG ZNF217 TRAF2 FOSB EBAG9 CASP8 TNFSF10 FAS ANGPT1 RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A TEK FADD SHC1-1 PRKCQ RASGRP2 RASGRP1 RASGRP4 LYN UBE2D3;UBE2D2 NFKBIA NTRK2 TIAM1 BDNF CDK5R1 AATF MAGED1 TGFBR1-1 TGFBR2 MAP2K2;MAP2K1 RAP1A RAPGEF1 MAPK1 BRAF MAPK3 CRKL FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 INSR GRB10 APOC1 GZMH;GZMB-1 APOC4 P4HB BUB1B CDC20 COL4A5 BUB3 MAD2L1 PRKAB2 EIF4EBP1 SHMT2 PDE1C GRK2 RDH11 PIP5K1A PIP5K1B PIP5K1C PRDM4 COL4A2 PRKAG2 COL4A1 COL4A4 COL6A2 SMPD3 COL4A3 COL6A1 SMPD2 COL6A3 COL6A6 COL6A5 IRS4 VPS29 SOX3 VPS35 SOX6 SOX7 SOX4 WLS SOX13 HECW1 VPS26A CCDC88C RSPO2 RSPO1 RSPO4 TMED5 LGR6 LGR5 LGR4 RAPGEF3 CTNNBIP1 PPARD KLHL12 RAPGEF4 CBY1 DACT1 ZNRF3 SYVN1 DERL2 OS9 IER3 FLT3LG PDGFB CD19 EGR1 CD28 SNAI1 SNAI2 STRN GAB2 PHLPP2 PHLPP1 IL33 CD86 KLB PGK1 CD80 ATN1 SALL4 MAF1 LTK PDGFRB FGF19 TNK2 FGFR4 AKT1S1 CRABP2 IL1RL1 TRAT1 RPS6KB2 PIK3AP1 SP1 ADRA1D ADRA1B ADRA1A TBXA2R GNA12 ARHGEF33 ARHGEF37 ARHGEF38 JAG2 PTEN FN1 SHH DUSP8 DUSP9 CILP NEURL1B CSN2-1 GRAP HHAT PPID FNTA AMOTL2 AMOTL1 MXD4 SAV1 PTPRU STMN1 MOB1A;MOB1B ADAP1 BEX3 STK4 STK3 FER LATS1 LATS2 PRKAA2 KDR MC2R GRB2 CNKSR2 CNKSR1 PEBP1 IGF1R IL6R TRIB3 CTBP2 CTBP1 APOE PCK1 APBB1IP CYP26A1 AVPR2 TLN1 GNAI1 GNAI2 GCG FNTB;CHURC1-FNTB HES5 ARAF DHH HEYL PORCN PDHA1 KSR1 KSR2 LRP5 LRP6 CYP26B1 MIB1 SH3GL3 SH3GL1 VCL CARM1 ERLEC1 DKK1 DKK2 DKK4 BRAP TPH1 MRAS ADH4 CGA HMOX2 RNF43 BAG4 DUSP16 DUSP10 CX3CR1 PTPN12 PLIN3 SH3KBP1 AVPR1B KREMEN1 KREMEN2 AVPR1A RDH5 CKB AVP SHOC2 AXL ABCG8 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 97%212718 EGFR interacts with phospholipase C-gamma EREG BTC EGF PLCG1 AREG TGFA EGFR HBEGF EPGN GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 97%9953170 GBP-mediated host defense SFN FURIN FNTB;CHURC1-FNTB FNTA GBP2;GBP3;GBP1 PGGT1B GBP5-1 PIM1 ACTG1 CASP1 ACTB-1 GBP7;GBP4 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956522 OTC variants cause OTC deficiency OTC SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839120 Signaling by FGFR1 amplification mutants EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination DRP2 TEAD1 SCD5 WWTR1 UTRN MAG CYP51A1 PRX SOX10 POU3F2 SMARCA4 SREBF2 NAB1 LAMA2 NAB2 YAP1-1 DAG1 LAMB1 EGR2 MBP ADGRV1 PMP22 POU3F1 LAMC1 MPZ HDAC2 ADGRG6 HMGCR INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair HGS INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%177243 Interactions of Rev with host cellular proteins NUP133 NUP107 NUP188 RANGAP1 NPM1-2 NUP50 POM121;POM121C RCC1 NUP54 NUP210 NUP93 KPNB1 NUP205 NUP42 AAAS XPO1 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 RANBP1 NUP155 NUP153 NUP35 NUP62 RAN NUP37 NDC1 SEC13 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels KCNJ16 KCNJ1 KCNJ10 DISEASES OF TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 97%9673013 Diseases of Telomere Maintenance DAXX ATRX TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells PPP2R1A ABL1 ITGB1 GNA11 CHUK ITGAV CAPNS1 IKBKB CAPNS2 ITGB3 IKBKG CAPN2 GNAQ PTK2 NFKBIA PPP2R2A;PPP2R2D VCL ANXA2 STAT1 PTPN1 RELA PPP2CB;PPP2CA ITGA5 YAP1-1 PPP2R1B NFKB1 IKBKE PIEZO1 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway OR52A5-2 OR2V2 OR11A1 OR8A1 OR8I2 OR10G9;OR10G7 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 LHX2 OR56B1-1 OR10W1 OR8B3;OR8B2-1 OR5B2 OR5D14 OR5D13 EBF1 OR52M1 OR10V1 OR4C12 OR6C3 OR5A2 OR5A1 OR4C15 OR9I1 OR2AG1;OR2AG2 OR10T2 OR52L1 OR4C45-1 OR52R1-2 OR6B2 OR6B1 OR2A25 OR51I2 OR2M2;OR2M3;OR2M7;OR2M5 OR10S1 OR51I1 OR4D11 OR4D10 OR2Z1 OR6A2 OR9G4 OR4E1 OR8K5-1 OR51Q1 OR2B6;OR2B2-1 OR4D9 OR5B12 OR5AP2 OR4D6 OR4D5 OR4D2 OR4D1 OR2H1-1 OR10Z1 OR2S2-1 OR5P2-4 OR4C6 OR4A15 ANO2 OR4C3 OR3A2 OR3A1 OR8K3 OR8K1 OR4C11-1 OR2L3;OR2L8;OR2L2;OR2L5-1 OR5AN1 OR8U8;OR8U1;OR8U9 OR6C2;OR6C68 OR6F1 OR2T2;OR2T35 OR51M1 OR10X1 OR8J3-1 OR5C1 OR1C1 OR2G2-1 OR51D1 OR6M1 OR7E24-1 OR2T11 OR1L1;OR1L3;OR1L8 OR5AK2-2 OR2D3 OR2D2 OR1B1 OR52E4 OR5J2 OR52E2-1 OR2AT4-1 OR2C3 OR6K6 OR2C1 OR51B2 OR5I1 OR6K2 OR52D1 OR9Q2 OR9Q1 OR51B6 OR4F6 OR2B3 OR10K2 OR2F1-2 OR2T29;OR2T5-3 OR14A2-1 OR2AJ1 OR51A4 OR2A5 OR51A7 OR52J3 RTP2 RTP1 OR4M1 OR10R2 OR8U3 OR6Q1 OR11H1;OR11H12 OR52I1;OR52I2-1 OR4F21;OR4F16;OR4F29;OR4F3 ADCY3 OR9G9;OR9G1 OR7C1;OR7C2-9 OR51G2 OR51G1 OR1F1 OR2H2 OR4L1 OR5B3-13 OR6P1 OR10Q1 OR52E8;OR52E6 OR5M10;OR5M1-1 OR2AP1 OR2B11 OR4A47-3 OR51F2 OR5M9 OR51F1 OR2G6 OR4K5 OR4K3 OR5M3 OR4K2 OR4K1 OR10P1 OR51E1 OR1D2 OR51E2 OR6N2 OR6N1 OR4F15 GNAL GNG13 GNB1 LDB1 CNGA2 CNGA4 OR11H4 OR2M4 OR4C13;OR4C46-2 OR6K3-1 OR1K1 OR4K17 OR1S1;OR1S2 OR4Q3 OR11H6 OR8G1;OR8G5 OR1J4 OR11G2 OR1J2 OR4P4 OR1J1 OR10AD1 OR6T1 OR4K13 OR7A10;OR7A17-11 OR51V1-1 OR13J1 OR2K2 OR1I1 OR6S1 OR5M11 OR5K4-1 OR10D3 OR8H2;OR8H3;OR8H1 OR14K1 OR4N5 OR5P3 OR10C1 OR5B17-3 LOC112268384;OR2A42;OR2A1 OR6C6-1 OR11L1 OR10H1;OR10H5;OR10H2 OR5W2 OR6Y1 OR52B2 OR52B6 OR5K3-3 OR1A1-1 OR1N2 OR1N1 OR6X1 OR1E1;OR1E2 OR52K1-1 OR52A1 OR5L2;OR5L1-1 OR1M1 OR4S2 OR5AC2-2 OR2AE1-2 OR10G2 OR14A16 OR10G3 OR8D2-1 OR7D4-5 OR4K14-1 OR5T1 OR6V1 OR10G6 OR6C4-1 OR10K1-1 OR52W1 OR5AS1 OR4F5;OR4F17;OR4F4 OR2T6 OR13C9 OR2T1 OR13C8 OR2L13 OR4X1 OR9A4 OR51T1 OR5V1-2 OR5AR1 OR2V1-1 OR2A2;OR2A14 OR1Q1 OR12D1;OR12D2-1 OR51S1 OR7G2;OR7G1-14 OR14C36-8 OR5B21 OR2J1;OR2J2;OR2J3-2 REEP1 OR13A1 OR2T27;OR2T7 OR4N2-1 OR4C16-2 OR14J1 OR13H1 OR2Y1 OR8D4 OR56B4 OR8D1 OR6C70 OR6C76 OR6C75 OR6C74 OR13G1 OR13C3;OR13C4 OR4B1-2 OR10A7 OR1L4;OR1L6-1 OR6C1-1 OR56A4 OR10A4 OR56A3 OR10A3 OR10A5 OR2A7;LOC107987545;OR2A4 OR4A16;OR4A5-1 OR4X2-2 OR2W3 OR8B8 OR2W1 OR8B4 OR13F1 OR12D3 OR5AU1 OR2T12;OR2T33;OR2T8-1 OR5K1;OR5K2 OR10J1-2 OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling PLA2G4A GNA14 GNG10 GNA15 GNG2 ADCY9 GNG5 GNG4 PRKAR1B GNA11 PRKAR1A GNG8 CDK5 PPP1R1B ADCY4 PPP3CC ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 PRKACB-1 GNAQ GNB2 PRKAR2A GNB1 PRKCG POMC GNB4 GNB3 ITPR1 PDYN ITPR2 GNB5 ITPR3 CAMK4 PPP3R1 PDE1C CAMKK1 GRK2 CAMKK2 GNAT3 PDE4D-1 PPP3CA PPP3CB GNAI1 GNAI3 GNAI2 OPRM1 CAMK2B CAMK2D CAMK2A PRKACA-1 PPP2R1A CAMK2G PDE4A PPP1CA PDE4C CALM3;CALM1 GNAL GNGT1 PRKCD NBEA PRKCA PPP2CB;PPP2CA PRKAR2B PLCB3 PPP2R5D PLCB4 PPP2R1B PLCB1 AHCYL1 PLCB2 KPNA2 PRKX MAPK1 PDE1B PDE1A CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation S100A8 HECTD1 HECTD2 TLR2 ASB10 HECTD3 TRIM41 RNF25 FBXL19 FBXL18 FBXL15 TRIM74;TRIM73;TRIM50 FBXL16 CDC20 FBXL13 FBXL14 B2M FBXL12 TRIM39 ASB8 ASB9 LNX1 ASB6 TRIM36 ASB7 STX4 TRIM37 ATG14 ASB4 ASB5 ASB2 TRIM32 SAR1B ASB1 PIK3R4 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 MIB2 BTRC PSMC3 PSMA1 RBCK1 PSMC4 PSMC1 SKP1 CANX FBXW11 UBA52 SEC24D-1 CUL1 RPS27A UBB;UBC UBE2V1 RBX1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E UBE2N ITCH LRRC41 VAMP3 PIK3C3 BECN1 SEC23A FCGR1A CUL3 CTSS VHL SEC24B KBTBD7 SEC24A MYD88 SEC24C CTSV;CTSL HMGB1-1 FBXO32 NEDD4L NCF1 TRIM63 NCF2 FBXO4 NCF4 FBXO6 VAMP8 FBXW4 PSME2 FBXW10;CDRT1 FBXW5 FBXW7 FBXW9 ELOC-1 FBXW2 ELOB STUB1 SEC13 SNAP23 TIRAP SOCS1 FBXL3 FBXL5 TLR6 RNF111 RBBP6 CD36 UBE2D3-1 CHUK BTK UBA7 HSPA5 UBE2L6 HERC5 IKBKB IKBKG LRR1 WWP1 CCNF KEAP1 CBLB SOCS3 DCAF1 SH3RF1 HERC4 HERC3 RNF115 HERC2 RNF114 HERC1 TRIM21 FBXO7 FBXO9 CALR-1 HERC6 TRAIP-1 WSB1 FBXO2 RNF123 S100A1 RNF126 HECW2 ANAPC13 UBE2J2 UBE2J1 RNF217 ATG7 TRIM11-1 HACE1 SIAH2 ERAP2 SIAH1 ERAP1 LNPEP TAP2 MEX3C TAP1 UBAC1 TAPBP FBXL8 FBXL4 FBXL7 DZIP3 RNF220 DET1 LRSAM1 TRIM9 ARIH2 RNF144B ITGB5 GAN PRKN RNF130 GPR75-ASB3;ASB3-1 ITGAV HUWE1 KLHL2 KLHL3 SEC31A UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 NEDD4 RLIM TRIP12 KBTBD8 SPSB4 UBE2D4 UBE3C UBE3D FBXO27 UBR2-2 LTN1 RNF19B UBE3A UBE3B UBE2Z FBXO21 FBXO22 NPEPPS RNF19A MYLIP FBXW12 AREL1 KCTD6 FBXW8 UBE2E3 FBXO17 UBE4A FBXO15 SMURF2 SEC61A2 MRC2 UBE2E2 SMURF1 LMO7 SEC61A1 SEC61G FBXO10 SEC61B FBXO11 PSME1 KLHL41 CYBB KCTD7 SEC22B CYBA RNF41 PSMB10 PSMB8 KLHL42 PSMB9 UBE2V2 CD207 CUL7 RNF34 CUL5 UBA6 UBA5 CUL2 UBR4 KLHL11 MRC1 KLHL13 UBR1 FBXO44 FBXO41 FBXO40 BTBD1 LONRF1 LY96 UBE2F UBE2H UBE2B KLHL25 ZBTB16 GLMN KLHL21 KLHL22 BTBD6 CD14 FBXO30 KLHL20 TLR4 FBXO31 CDC34 UBE2W UBOX5 UBE2U MKRN1 UBA3 RNF182 TPP2 UBE2O BLMH UBE2D3;UBE2D2 UBA1 FGB UBE2K FGA TRIM71 RNF14 KBTBD13 FGG UFL1 UBE2Q1 UBE2Q2 UBE2D1 TRIM69 UNKL ANAPC10 DTX3L ANAPC11 PJA2 PJA1 FZR1 CDC23 TRAF7 CDC26 UBE2R2 CDC27 RNF138-1 THOP1 ANAPC7 RNF213-2 MGRN1 UBE2C ASB13 UBE2E1 ASB14 RNF6 ASB11 UBE2S RNF7 CDC16 ASB12 ANAPC4 ASB17 ANAPC5 RNF4 ANAPC1 RCHY1 ANAPC2 ASB18 FBXL22 ASB15 TLR1 ASB16 FBXL20 PDIA3 ZNRF1 S100A9 ZNRF2 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 97%3595172 Defective CHST3 causes SEDCJD BCAN VCAN DCN CHST3 CSPG5 NCAN BGN NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK RELB FBXW11 UBA3 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 NFKB2 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A MAP3K14 PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair CCNA2-1 CCNA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 KAT5 POLH CHEK1 HUS1 MUS81 C1orf112 EME1-1 BRCA2 DNA2 RAD51AP1 RHNO1 SLX4 EME2 FIGNL1 GEN1 XRCC2 XRCC3 SIRT6 PALB2 SPIDR SLX1A;SLX1B ATRIP BARD1 SEM1 RAD17 ATM ATR BRCA1 BABAM1 BABAM2 RMI2 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 RAD51D H2BC5 PCNA UBA52 WRN H2BC1 RPA1 HERC2 RPA2 CDK2 RPA3 RPS27A RAD1 UBB;UBC CLSPN MRE11 NBN RTEL1 ABL1 BLM PIAS4 RAD51 UBE2I POLD1 UBE2N RAD9B H2BC21 PARP1 RAD9A RAD51B RAD51C EXO1 SUMO2 TOPBP1 RFC5 RFC3 RFC4 RFC2 UBE2V2 RBBP8 TP53BP1 RAD50 POLQ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LIG1 RNF168-1 PPP4R2 TIPIN TIMELESS PPP4C POLK RAD52 POLE RFC1 PARP2 H2BC15;H2BC3;H2BC11;H2BC12 LIG3 NSD2 POLD3 POLD4 POLD2 XRCC1 POLE4 FEN1 BRIP1 ERCC4 POLE2 RNF4 ERCC1 POLE3 GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism AKR1B1 GALT PGM1 GALM-2 GALE GALK1 PHENYLALANINE METABOLISM%REACTOME%R-HSA-8964208.2 Phenylalanine metabolism ASRGL1 KYAT1 PAH QDPR PCBD1 IL4I1 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 97%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways SFN YWHAZ YWHAQ YWHAE YWHAB CAV1 YWHAH PDPK1 YWHAG AKT2 AKT3 AKT1 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 97%8942233 Intestinal infectious diseases PDZD3 GUCY2C DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 97%73928 Depyrimidination ACD TINF2 TDG H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 MBD4 SMUG1 NEIL2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 NEIL3 NEIL1 H2AC20 NTHL1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 OGG1 H2AC14 RIBAVIRIN ADME%REACTOME DATABASE ID RELEASE 97%9755088 Ribavirin ADME SLC28A2 SLC29A1 PNP-1 SLC29A3 SLC28A3 NT5C2 NME2 ADA ITPA ADK NME1 GLYCOSPHINGOLIPID TRANSPORT%REACTOME DATABASE ID RELEASE 97%9845576 Glycosphingolipid transport GLTP ESYT3 PLEKHA8 ARF1 ESYT2 CPTP CLN3 ESYT1 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 97%168927 TICAM1, RIP1-mediated IKK complex recruitment RIPK3 UBE2D1 UBE2V1 UBE2D3-1 TLR3 BIRC2 CHUK TICAM1 BIRC3 RPS27A RIPK1 TRAF6 UBB;UBC IKBKB IKBKG UBE2N UBE2D3;UBE2D2 UBA52 UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%162585 Uncoating of the HIV Virion PPIA ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 97%9028731 Activated NTRK2 signals through FRS2 and FRS3 FRS2 BDNF SOS1 PTPN11 HRAS FRS3 NRAS NTRK2 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System STOM LIMK1 AGPAT2 SERPINB1 DTX4 STAT6 NFATC2 NFATC1 PLCG1 PRKACA-1 TNFAIP3 PPP2R1A BTRC CEP290 CYLD BIRC2 SKP1 BIRC3 HSP90AA1 OPTN-1 FBXW11 TTR RAB14 VAPA UBA52 CUL1 TANK FUCA1 ATF1 RPS27A ELK1 RPS6KA3 RPS6KA5 UBB;UBC RPS6KA2 RPS6KA1 MAP3K8 MEF2A DYNC1H1 MAP2K3 MAP2K4 MEF2C MAPKAPK3 MAPK9 TUBB4B COLEC11 MAPK8 MAP2K7 HSP90B1 TUBB4A;TUBB;TUBB8B;TUBB8 MAPK10 TNIP2 TXN PRKDC BCL2 BCL2L1 DERA APEH CAPN1 ADAM10 ADAM8 CR1L;CR1 PSEN1 NCSTN A2M ELANE PTGES2 PLAUR PLAU HRG CTSS SERPINB6-2 MMP25 PAFAH1B2 CTSK CASP3 TIMP2 CTSG CTSD CTSB PTPRJ CTSV;CTSL MMP8 MMP9 OTUD5 DDX41 IDH1 ITGAL CD44 CRP COLEC10 FCN2;FCN1 TBC1D10C PRSS3;PRSS2;PRSS1 HK3 KLKB1 PTPN4 RAB31 LGALS3 H2AC14 PDXK NOS3 YES1 ALDH3B2;ALDH3B1 TRAPPC1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP RAB27A MAPK13 GDI2 H2AC20 H2AB2;H2AB3;H2AB1 CAT IQGAP1 RETN CD36 CYB5R3 RAB10 RAB18 UBE2D3-1 ECSIT FPR1 PGAM1 H2BC5 H2BC1 EP300 H2AC4 DBNL GSN GPR84 CRCP POLR3GL POLR3A POLR3B FABP5 ABL1 POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K ACTB-1 KPNB1 H2BC21 H2AZ2;H2AZ1 MME POLR1C POLR1D ADGRE5 FPR2 ADGRE3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H POLR2L PROS1 H2BC15;H2BC3;H2BC11;H2BC12 CD177 FGB FGA FGG F2 PTAFR EPPIN;EPPIN-WFDC6 PGLYRP4 PGLYRP3 PGLYRP2 LEAP2 LYZ-1 GMFG DEFB1 SERPING1 CLU MCEMP1 DEFB109B KNG1 RNF216 BPIFA1 HP;HPR REG3G;REG3A-1 CCR6 F12 FUCA2 ATP7A PGLYRP1 AHCYL1 CAMP OLR1 CCR2 DEFB131B;DEFB131A DEFB119 YPEL5 DEFA6;DEFA4;DEFA5 DEFB118 DEFB116 TOM1 ARSA SLC11A1 ARL8A DEFB114 RNASE6 NIT2 DEFB110 TLR1 RNASE3;RNASE2-2 ACP3 BPI S100A9 SNAP29 S100A8 LTF RNASET2 TLR2 TMBIM1 DEFB129 TRIM56 DEFB128 CANT1 DEFB127 DEFB106B;DEFB106A MUC12 DEFB125 MUC15 DEFB123 DEFB121 ART1 ITLN2;ITLN1-2 PDZD11 MUC3A RNASE7 MUC5AC CHGA DEFB135 DEFB107A;DEFB107B C6orf120 METTL7A-1 S100A7A;S100A7 CFP SLPI DEFB132 ATOX1 CRISPLD2 DEFB130B;DEFB130A CTSA DEFB105A;DEFB105B TMEM63A CD4 SYNGR1 BPIFB2 BPIFB1 MUC1 NBEAL2 BPIFB4 MUC2 BPIFB6 LCN2 DEFB103A;DEFB103B MUC7 DEFB4A;DEFB4B MUC4 MUC6 FCER1A PSMD12 MUC17 FCER1G PSMD11 PSMD14 MUC5B PSMD13 MUC20 WASL MUC21 RAP2B TAX1BP1 PSMA7 CAB39 DNAJC3-1 C1orf35 PSMD8 PSMB6 PSMB7 GCA PSMD6 PSMB4 LAT2 PSMD7 PSMB5 SRP14 PSMB2 ENPP4 PSMB3 PSMD2 PSMD3 IRAG2 PSMB1 ADGRG3 PSMD1 GGH ADA2 ADRM1 MS4A3 TNFAIP6 CHI3L1 PSMC2-1 MS4A2 PSMA2-1 PSMA5 ATP8A1 ACAA1-1 TEC SEM1 PSMA6 AAMP PTX3 PSMC5 PSMA3 FRMPD3 PSMC6 PSMA4 TOLLIP ATP6V1E1 AHSG PSMC3 ATP6V1E2 PLEKHO2 PSMA1 ATP6V1G1 GRN PSMC4 ATP6V1G2 PSMC1 ATP11B CTNNB1 TMEM179B ATP11A RAB3D RAB44 LAMP1 LAMP2 KCMF1 ILF2 RAF1 RAB37 RAB4B ATP6V0D1 FGL2 ATP6V0D2 HSPA1A;HSPA1B RAB24 ATP6V1A CPPED1 KRT1 C1QB CPB2 TXK CD81 C1R ATP6V0A2 VAT1 C5AR2 PRKCD CFI ATP6V0A4 CSTB SVIP C5AR1 C8B QPCT ATP6V1D C8A COTL1 MAPKAPK2 ATP6V1C1 CPN2 C2 COPB1 ATP6V1F CPN1 ATP6V0A1 LPO C5 ATP6V1C2 C8G C6 ATP8B4 C7 CLEC12A C9 TMEM30A SCAMP1 CD59 SERPINB3;SERPINB4-1 CD55 CR2 CFHR1;CFHR2 CFH-3 C1QC PIGR HSPA8 TMC6 SERPINB10 MAPK14 SERPINB12 MAPK11 PKM TCIRG1 LRG1 OLFM4 PTPRB ATP6V0B PRCP ATP6V1B2 PNP-1 VPS35L ATP6V0C ATP6V1B1 DHX58 DHX36 TREM2 SURF4 GRAP2 PRG2 KLRC4-KLRK1;KLRK1 PRG3 KLRC4;KLRC3;KLRC2;KLRC1 ORM2;ORM1 TYROBP QSOX1 KLRD1 LCP2 CD53 CD63 PGRMC1 CREG1 CD68 ATP6V1G3 MPO OSTF1 CD93 PRKACB-1 DOK3 CTSZ TARM1 ANPEP MVP PDAP1 ATP6V0E2;ATP6V0E1 S100P ITCH ATP6AP2 ABCA13 NHLRC3 UNC13D RNF125 A1BG CRACR2A PRDX4 S100A11 PA2G4 CD3G SERPINA3 SYK FGR HCK NFAM1 AGA CARD9 HRAS ERP44 FCGR3A;FCGR3B FYN SLCO4C1 FCGR1A GHDC EPX ALPK1 CLEC4A NLRX1 NRAS CLEC4D CLEC4E AGER S100A12 BRI3 N4BP1 HVCN1 USP18;USP41 CFD CLEC7A MYD88 C3-1 CFB CLEC6A NFKBIB SAA2;SAA1 NKIRAS1 KCNAB2 NKIRAS2 IKBIP IRAK4 PELI1 PLCG2 TLR9 LRRC14 SIGLEC15 PTPRN2 USP14 PELI3 STK11IP PELI2 NLRC5 TIFA HMGB1-1 DNASE1L1 MAP3K1 ATAD3A;ATAD3B CNPY3 DPP7 SIGIRR DNAJC13 IRAK3 CRISP3 HEBP2 CMTM6 MLEC FTH1 XRCC6 XRCC5 VAMP8 PTPRC RAB5C ASAH1 TXNDC5 MAPK12 AP1M1 FTL-1 AOC1 IGF2R GYG1 SOCS1 ITPR1 ITPR2 ITPR3 PPP3R1 PSAP PPP3CA PPP3CB HEXB GM2A GLB1 GUSB ARSB CHUK UBA7 CXCL2;CXCL3;CXCL1-1 DDX58 ISG15 UBE2L6 HERC5 PFKL IFIH1 CXCR1 IKBKB IMPDH1 TRIM25 IMPDH2 CXCR2 IKBKG AP2A2 PPBP DNM1 DNM2 DNM3 TRIM21 PPP2CB;PPP2CA PPP2R5D PPP2R1B ATG7 MGST1 NDUFC2;NDUFC2-KCTD14 HUWE1 PLAC8 GLIPR1 ITK MANBA NME2 AMPD3 PIK3R2 PIK3CB ALDOC PIK3R1 ALDOA UBR4 PIK3CA PTPN6 DNAJC5 ALOX5 UBA3 UBE2K UBE2D1 RELA MAN2B1 NFKB1 NAPRT SLC15A4 SLC2A5 ICAM2 TBK1 ACTR1B CTSH CTSC B2M RELB ACTR10 TRIM32 ITGB2 PIK3R4 RIPK3 APP NLRC4 MEFV NFKB2 PANX1 GSDME PYCARD P2RX7 PSTPIP1 AIM2 CASP1 TXNIP NLRP1 ATG12-1 SUGT1 ATG5 MAGT1 IKBKE TOMM70 RIPK2 RAP1B ANO6 PRKCE PLPP5 PLPP4 HSPA6 MYO10 EEF1A1 MYO5A SIKE1 MYO1C CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 EEF2 TLR8 TLR7 RNF135 PKP1 STING1 VCP-1 MAP3K14 DSC1 MAP3K7 GSDMD TNFRSF1B CASP9 GOLGA7-1 MASP1 UBE2V1 NOS1 TKFC IRAK1 IRAK2 NLRP3 IST1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E MAVS UBE2N TAB3 TAB2 RBSN TAB1 HSP90AB1 PRKCSH FRK PDPK1 DDOST C3AR1 IRF3 DOCK2 IL18 HBD;HBB TRAF3 CDC42 IL1B MBL2-1 TRAF6 IRF7 PIK3C3 NOD1 NOD2 CAPZA1 CAPZA2 MGAM IFNB1-4 PTPN11 CHIT1 NOS2 CALM3;CALM1 ATP6V1H RAB7A CNN2 CHRNB4 CFL1 PAK2 ANXA2 MIF CCT2 LRRC7 CCT8 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 MYH9 ATF2 PRDX6 B4GALT1 PECAM1 RAB6A JUN CDK13 MAPK7 RAC1 RHOA CASP10 ELMO1 ELMO2 CRK FOS DOCK1 NFATC3 P2RX1 LAMTOR2 LAMTOR1 LAMTOR3 VNN1 MRE11 ITGAV MAP2K6 PIN1 COMMD9 CASP2 TRPM2 COMMD3 APAF1 CAND1 TICAM2 TLR3 LY96 TRAF2 TICAM1 CASP8 PADI2 RIPK1 CD14 FADD TLR4 CDC34 PRKCQ CARD11 BCL10 RASGRP2 RASGRP1 MALT1 RASGRP4 LYN UBE2D3;UBE2D2 ICAM3 NFKBIA TREM1 LAIR1;LAIR2-1 SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 OSCAR CD300E MAP2K2;MAP2K1 RAP1A MAPK1 MAPK3 SIGLEC5;SIGLEC14 SOS1 NPC2 APOB SELL CST3 TSPAN14 LTA4H LGMN ROCK1 MUC13 DSP CD47 CKAP4 DSG1 SIRPA;SIRPB1;SIRPG SIRPB1 RAB3A LBP GSTP1 CYFIP2 CYFIP1 NCKAP1 CD180 LY86 WASF1-1 ITGAM EEA1 WIPF1 TASL IRF5 WIPF2 WIPF3 ACLY DYNC1LI1 CD19 SLC27A2 GAB2 IQGAP2 NCKAP1L JUP SDCBP ARHGAP9 CASP5;CASP4 ARPC1B ARPC1A HPSE SNAP25 ALAD PGM2 PGM1 C1S SERPINA1 DHX9 ABI2 BST2 ABI1 PPIE NCF1 NCF2 NCF4 STK10 NEU1 NFASC ARPC4 ARPC5 BST1 ARPC2 ARPC3 RAB5B NF2 SNAP23 TIRAP CAP1 CD33-1 NCK1 ACTR2 LCK GAA APRT AGL-1 TLR6 TLR5 WASF2 WASF3 ORMDL3 BAIAP2 CGAS BTK HGSNAT C4BPA C4BPB LOC110384692;C4A;C4B_2;C4B DSN1 PTK2 FAF2 ITGAX TLR10 C1QBP STBD1 SPTAN1 VAV3 S100A1 RHOG RHOF IFI16 VAV1 NLRP4 TREX1 VAV2 DEGS1 WAS PAK1 PCBP2 PAK3 MYO9B ZBP1 VCL RAB9B LRRFIP1 DYNLT1 GALNS ACTG1 GLA PPIA CDA ARG1 TP53 CYBB ARMC8 CYBA ARHGAP45 PLA2G2A-1 BIN2 CPNE3 GNS DGAT1 NCKIPSD HMOX1 DDX3X-1 HMOX2 CSNK2B CLEC5A VTN TCN1 PLD4 DIAPH1 PLD1 PYGB PLA2G6 GPI PLD3 PLD2 PYGL UNC93B1 ACTR3-1 CLEC4M;CD209-2 SLC44A2 LPCAT1 MOSPD2 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-HSA-6814848.2 Glycerophospholipid catabolism GDPD1 GDE1 GDPD3 ENPP6 GDPD5 PNPLA6 PNPLA7 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 97%9636003 NEIL3-mediated resolution of ICLs NEIL3 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism GNS DCXR PPP1R3C GLB1 HYAL1 IDS GUSB ARSB HGSNAT RPIA EPM2A GBE1 NAGLU GYG2 GYG1 G6PC1 GYS2 KHK GYS1 G6PC3 UBA52 GAA TALDO1 GALNS SI LCT RPS27A SGSH UBB;UBC ALDOB IDUA SLC37A4 NHLRC1 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions GJA1 CLTB DNM1 DNM2 DAB2 CLTCL1 CLTC CLTA SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL CRLS1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions FLT1 VEGFB VEGFC FLT4 VEGFD KDR VEGFA PGF GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9840310 Glycosphingolipid catabolism GLB1L2 SMPD3 GBA GLB1L GLB1 SMPD2 SMPD4 SMPD1 ARSD-1 ARSL ARSB ARSJ ARSK ARSH ARSI ARSG CTSA ENPP7 SUMF2 SUMF1 STS GBA2 GALC PSAP GLA M6PR NEU2 ASAH1 NEU3 ASAH2 NEU1 ARSA HEXB GM2A HEXA GLB1L3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) RPS14 NCBP1 RPS17 RPS16 RPS19 RPS18 RPS11 GSPT2 RPL10A GSPT1 RPS10 RPS13 RPS12 UPF2 ETF1 RPL27A RPL10;RPL10L-1 NCBP2-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A PPP2R1A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 PPP2CB;PPP2CA RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 DCP1A EIF4G1 RPSA EIF4A3 CASC3 RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 SMG1 RPL8 RBM8A SMG9 SMG7 RPL9 SMG8 RPL6 SMG5 SMG6 RPL7 UPF1 RPS4X MAGOH;MAGOHB RPL35 RPL38 RPS3A UPF3B RNPS1 RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 PPP2R2A;PPP2R2D RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 97%9013694 Signaling by NOTCH4 RBX1 ACTA2 DLL4 PSENEN TACC3 HEY1 HEY2 CREBBP JAG1 ADAM10 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 SMAD2;SMAD3 RBPJ PSMA7 PSMD8 PSEN1 PSMB6 PSMB7 MAML2 PSMD6 MAML1 PSMB4 PSMD7 NCSTN PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 MAML3 NOTCH2 ADRM1 NOTCH4 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 HES1 PSMC5 PSMA3 SNW1 PSMC6 MAMLD1 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 KAT2B KAT2A HES5 AKT1 UBA52 YWHAZ CUL1 EP300 RPS27A PSEN2 UBB;UBC FLT4 APH1A APH1B CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110329 Cleavage of the damaged pyrimidine ACD TINF2 TDG H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 MBD4 SMUG1 NEIL2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 NEIL3 NEIL1 H2AC20 NTHL1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 OGG1 H2AC14 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H RPL27A EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3D EIF3A EIF3B RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 RPLP2 RPL36-1 RPL35A RPS27L RPS15A RPS3 UBA52 RPS2 RPL18A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 EIF4A2 EIF4A1 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 EIF2S2 EIF4E EIF4B EIF2S3;EIF2S3B EIF2S1 RPL3L RPL5-1 RPLP1-2 RPL23A RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 RPS15 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960525.1 CASP5-mediated substrate cleavage GSDMD CASP3 IL18 CASP5;CASP4 IL1B TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling TGFBR1-1 ARRB2 TGFBR2 TGFBR3 GIPC1 TGFB2 TGFB1 ARRB1 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 97%9845622 Defective VWF binding to collagen type I VWF ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-HSA-2046106.2 alpha-linolenic acid (ALA) metabolism ACOT8 ELOVL1 SCP2 ELOVL2 ELOVL3 FADS2 ACSL1 HSD17B4 ABCD1 ELOVL5 ACAA1-1 FADS1 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus PSEN2 YWHAZ APH1A APH1B NOTCH4 PSEN1 DLL4 JAG1 PSENEN NCSTN ADAM10 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME%R-HSA-9705462.2 Inactivation of CSF3 (G-CSF) signaling SOCS3 STAT1 TYK2 UBE2D1 STAT5A STAT3 UBE2D3-1 STAT5B CSF3 RPS27A SYK UBB;UBC HCK RNF7 ELOC-1 JAK1 ELOB CSF3R CUL5 JAK2 LYN UBE2D3;UBE2D2 SOCS1 UBA52 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) FGF20 FRS2 GAB1 SOS1 FGF23 FLT3LG PIK3CA PTPN11 AKT2 GAB2 IRS4 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 FGF10 FGF19 FGFR4 IRS2 FLT3 IGF1R PIK3R4 THEM4 IGF2 PDPK1 IGF1 TRIB3 IRS1 PIK3C3 PIK3R2 CILP PIK3CB HRAS PIK3R1 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins PROC F2 F7 FURIN F9 PROS1 F10 GAS6 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9022707 MECP2 regulates transcription factors RBFOX1 MEF2C PPARG GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-1630316.7 Glycosaminoglycan metabolism EXT1 ABCC5 EXT2 CHSY3 PXYLP1 FMOD LUM B4GALT6 CHSY1-1 B4GALT7 UXS1 B4GALT4 CHPF B4GALT5 NDST2 NDST1 SLC26A11 NAGLU CSGALNACT1 NDST4 NDST3 CHP1 PRELP CSGALNACT2 SDC4 KERA B3GAT3 CEMIP SDC2 B3GAT2 SDC3 B3GAT1 SLC26A2 SLC26A1 ST3GAL4 HMMR ST3GAL1 ST3GAL2 ST3GAL3 HS3ST3A1 HYAL2 B4GALT1 SDC1 IDUA HEXB NCAN HEXA BGN GLB1L3 ST3GAL6 GLB1L2 VCAN GLB1L GLB1 HYAL1 HYAL3 HYAL4 IDS CHPF2 CSPG5 GUSB ARSB CHST6 CHST7 GPC1 GPC3 GPC2 CHST1 GPC5 HPSE2 GPC4 SLC35B3 CHST2 GPC6 SLC35B2 CHST3 HS6ST1 HS6ST2 HS6ST3 EXTL2 AGRN HAS1 HAS3 HAS2 HS3ST3B1 EXTL3 SLC35D2 STAB2 SLC9A1 DSEL OGN HSPG2 HS3ST5 BCAN HS3ST6 HS3ST4 HPSE HS3ST1 HS3ST2 B3GALT6 B4GAT1 GALNS UST XYLT2 B3GNT7 XYLT1 B3GNT4 DSE FAM20B B3GNT3 GLCE B3GNT2 SPAM1 GNS CHST11 CHST12 CHST15 CHST13 CHST14 CTSV;CTSL LYVE1 DCN CD44 OMD ACAN B4GALT2 B4GALT3 SGSH HS2ST1 PAPSS2 PAPSS1 SLC17A5 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 97%9706369 Negative regulation of FLT3 CBL ABL2 FLT3LG SLA2 PTPRJ RPS27A SH2B3 UBB;UBC CSK SLA SOCS6 FLT3 SOCS2 UBA52 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-110362.4 POLB-Dependent Long Patch Base Excision Repair FEN1 PARG POLB PARP2 APEX1 ADPRS PARP1 LIG1 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8934593 Regulation of RUNX1 Expression and Activity CDK6 PML PTPN11 TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 SRC AGO3;AGO1 TNRC6B CCND1 CBFB RUNX1 CCND3 CCND2 VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%5651801 PCNA-Dependent Long Patch Base Excision Repair RPA1 RPA2 POLD3 POLD4 RPA3 POLD2 RFC5 RFC3 LIG1 RFC4 POLE4 FEN1 RFC2 POLB POLE POLE2 RFC1 APEX1 POLE3 POLD1 PCNA DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex TGIF1-1 ITGB1 ITGB5 ITGB8 PMEPA1 CDK8 ITGAV WWTR1 ITGB6 PRKCZ PPP1CC UCHL5 COL1A2 CCNC-1 STRAP PPP1R15A USP15 SP1 PARP1 SMAD2;SMAD3 ATP1B4 CGN F11R FKBP1A TGIF2 PARD3 SKI ITGA8 E2F4-1 PARD6A SMAD4 SMURF2 MTMR4 SMURF1 SERPINE1 TFDP1 JUNB SMAD7 RNF111 TFDP2 RBL1 YBX1 MYC PPP1CB HDAC1 SNW1 PPP1CA CCNK UBE2D3-1 USP9X CCNT1 NCOR2 TGFB1 NCOR1 RHOA TGFBR3 ITGB3 NEDD4L CDKN2B XPO1 UBA52 CBL UBE2D1 FURIN PPM1A CDK9 EP300 CCNT2-1 RPS27A E2F5 MEN1 TGFBR1-1 LTBP4 ARHGEF18 TGFBR2 LTBP2 UBB;UBC LTBP3 LTBP1 MAPK1 TGFB2 MAPK3 TGFB3 SKIL STUB1 TRIM33 BAMBI LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9969896 Lanosterol biosynthesis MVD FDPS GGPS1 MVK IDI1 HMGCS1-1 FDFT1 IDI2 SQLE PLPP6 LSS ACAT2 PMVK KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs KIT ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 97%9700645 ALK mutants bind TKIs ALK EML4 NPM1-2 STRN HIP1 BCL11A PPM1B FN1 PRKAR1A CLTC BIRC6 EIF2AK3 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA NUP214 PRKCD PRKCA ANP32A;ANP32D ELAVL1 XPO1 SET-1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse MYL6 RND1 ARHGEF11 ROCK2 LIMK2 LIMK1 MYH14 ARHGEF12 MYH11 SEMA4D PLXNB1 MYH10 RHOA RHOC MYL12B ERBB2 RHOB ROCK1 MYH9 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 97%174577 Activation of C3 and C5 C3-1 CFB LOC110384692;C4A;C4B_2;C4B C2 C5 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells CBL MET CTNND1 CBLL1 EPS15 SH3GL2 SRC CTNNB1 SH3KBP1 RPS27A HGS UBB;UBC CDH1 SH3GL3 STAM SH3GL1 STAM2 UBA52 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 97%9759774 Diseases of mitochondrial beta oxidation MMAA MMUT REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9861718 Regulation of pyruvate metabolism PDK4 MKLN1 LDHA RANBP9 PDHB MAEA GSTZ1 RMND5B RMND5A SIRT4 UBA52 DLD DLAT PDPR PDK3 RPS27A WDR26 PDK2 GID4 PDK1 GID8 UBB;UBC PDHX ME1 ARMC8 PDHA1 NEK1 PDP1 PDP2 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620920 Cargo trafficking to the periciliary membrane SMO INPP5E CCT8 CCT5 CCT4 HDAC6 ARF4-1 CYS1 LZTFL1 UNC119B ARL6 ARL3 MCHR1 NPHP3 ARL13B RAB11FIP3 BBS2 BBS1 RAB3IP BBIP1 PKD2 PKD1 BBS9 CNGA2 BBS7 CNGA4 BBS5 BBS4 MKKS EXOC8 RAB8A EXOC7 SSTR3 BBS10 BBS12 RP2 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 CNGB1 EXOC1 ASAP1 PDE6D RHO GBF1 RAB11A ATAT1 TTC8 CCT3 CCT2 TCP1 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 97%8935964 RUNX1 regulates expression of components of tight junctions RUNX1 OCLN-1 TJP1 CLDN5 CBFB CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964026 Chylomicron clearance LDLRAP1 LDLR APOE APOB LIPC PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import DDO SLC27A2 PAOX PHYH-4 PECR PEX10 PEX2 HMGCL PEX12 PEX13 PEX26 PEX14 ACOX2 ACOX3 IDE SCP2 PIPOX GSTK1 CROT DHRS4 HACL1 ACOX1 TYSND1 HSD17B4 CAT ACOT8 ACOT2;ACOT1 ECH1 AGXT HAO1 ACAA1-1 NUDT7 ACOT4 ZFAND6 UBE2D3-1 MPV17 USP9X PEX1 EHHADH-1 PEX7 PEX6 GNPAT NOS2 EPHX2 IDH1 AGPS UBE2D3;UBE2D2 UBA52 UBE2D1 AMACR LONP2 DAO BAAT RPS27A UBB;UBC CRAT NUDT19 DECR2 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CNOT8 CNOT9 BTG2 NPM1-2 CNOT10 CNOT4 CNOT6 TNKS1BP1 TP53 RGCC CNOT7 CNOT6L CNOT11 PLK2 CNOT1 CNOT2 PLK3 CNOT3 CENPJ CDC25C PLAGL1 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) VAMP2 VAMP1 SV2C SV2B SV2A TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) SYT1 VAMP2 VAMP1 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%167590 Nef Mediated CD4 Down-regulation AP2A2 ATP6V1H LCK AP2S1 CD4 ARF1 AP2A1 AP2B1 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 MET STAT3 HGF BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs ALOX12 PTGS2-2 ALOX5 ALOX15 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants PDGFRA TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 97%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation SPR PRKG2 CALM3;CALM1 PTS GCHFR NOS3 DHFR2;DHFR GCH1 HSP90AA1 AKT1 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 97%2299718 Condensation of Prophase Chromosomes CDK1 NCAPH2 NCAPG2 CCNB1 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ NCAPD3 SET-1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MCPH1 SMC4 H2AC4 SMC2 RB1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 KMT5A PLK1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 H2AC14 H2BC21 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 97%5358346 Hedgehog ligand biogenesis P4HB IHH PSMD12 PSMD11 ADAM17 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 SHH PSMB4 PSMD7 ERLEC1 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 HHAT PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 DHH GPC5 UBA52 DISP2 SCUBE2 NOTUM VCP-1 RPS27A SYVN1 DERL2 UBB;UBC OS9 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 97%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 ADAM17 DLL1 JAG2 DLL4 JAG1 ADAM10 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69186 Lagging Strand Synthesis PRIM2 RPA1 PRIM1 RPA2 POLA1 POLA2 POLD3 POLD4 DNA2 RPA3 POLD2 RFC5 RFC3 LIG1 RFC4 FEN1 RFC2 RFC1 POLD1 PCNA SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9938024.1 Somatic hypermutation of immunoglobulin genes HOXC4 DPF1 DPF2 EAF1 DPF3 EAF2 SMARCC1 SMARCC2 RELB CTDP1 APEX2 PAXIP1 TAF9 POLR2A SUPT6H POLR2B ZBTB17 POLR2C CREBBP POLR2D AFF4 SS18L1 POLI POLR2G POLH TAF9B IRF8 POLR2I SMARCA2 SMARCA4 STAT6 MLLT1 TAF15 MLLT3 IWS1 TAF12 NFKB2 TAF13 TAF10 MCM3AP TAF11 SSRP1 TAF8 TCEA1 TAF7 ASH2L BATF TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 SS18 NCOA6 ACTL6A MAFK CDC73 PAX5 LEO1 MYB PCNA UBA52 DIS3 PMS2 MLH1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 RPS27A EXOSC8 EXOSC3 EXOSC2 UBB;UBC EXOSC1 REV1 CTNNBL1 MAD2L2 REV3L KMT2D KMT2C MSH2 STAT3 CTR9 RTF1 ACTB-1 PAF1 BCL6 DPY30 PAGR1 BCL7A BCL7C BCL7B WDR5 EXOSC10 EXO1 KDM6A TBP C1D MPHOSPH6 ARID1A ARID1B RFC5 RFC3 RFC4 RFC2 MSH6 SMARCD1 CEBPA SMARCD2 JUND SMARCD3 E2F7 E2F8 E2F2 CCNK CCNT1 RBBP5 FOSB SUPT16H POLR2E AICDA POLR2F GTF2F1 POLR2H GTF2F2 POLR2L SMARCE1 RFC1 SUPT4H1-1 RELA SUPT5H CDK9 POLD3 POLR2J;POLR2J2;POLR2J3 CCNT2-1 POLD2 E2F5 TAF4B NFKB1 ELL ELOC-1 WDR61 TAF7L ELOA MEF2B;BORCS8-MEF2B NELFB SMARCB1 ELOB NELFCD NELFA NELFE BACH2 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 97%3322077 Glycogen synthesis PPP1R3C UGP2 RPS27A EPM2A UBB;UBC GBE1 PGM1 GYG2 GYG1 GYS2 GYS1 NHLRC1 UBA52 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176033 Interactions of Vpr with host cellular proteins SLC25A4 NUP133 NUP107 NUP188 NUP50 POM121;POM121C BANF1 NUP54 KPNA1 NUP210 NUP93 PSIP1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 SLC25A5 NUP62 SLC25A6 NUP37 NDC1 SEC13 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 97%9616222 Transcriptional regulation of granulopoiesis CDKN1A STAT3 CEBPE GFI1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CBFB TAL1 RUNX1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 DEK H2BC15;H2BC3;H2BC11;H2BC12 IL6R H2BC5 MYB H2BC21 H2BC1 CEBPB LEF1 RXRA CDK4 H2AC20 KLF5 CDK2 RARA H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EP300 FLI1 H2AC4 TFDP1 GATA2 TFDP2 CEBPA CSF3R KMT2A MYC E2F1 SPI1 H2AC14 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203641 NOSTRIN mediated eNOS trafficking DNM2 WASL NOSTRIN CAV1 NOS3 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation GLB1L2 GNS GLB1L GLB1 OMD GALNS ACAN FMOD LUM PRELP KERA HEXB HEXA GLB1L3 OGN EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162594 Early Phase of HIV Life Cycle XRCC6 XRCC4 XRCC5 BANF1 KPNA1 LIG1 PPIA LIG4 FEN1 PSIP1 CXCR4 CD4 CCR5 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%901042 Calnexin calreticulin cycle CANX UBA52 PRKCSH EDEM2 CALR-1 EDEM3 RPS27A AMFR SYVN1 DERL2 EDEM1-1 RNF5 UBB;UBC RNF103 MAN1B1 OS9 RNF139 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 SEL1L GANAB PDIA3 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME%R-HSA-9968551.1 Regulation of GBP-mediated host defense SFN GBP2;GBP3;GBP1 PIM1 CASP1 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants ALK ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism PTGIS PLA2G4A HPGDS PON3 PTGES3-1 HPGD PON2 PON1 LTC4S ALOX15B TBXAS1 ALOX5AP CYP1B1 CYP4F22 LTA4H PRXL2B CYP2J2-1 PTGES2 ALOX12B GPX1 CYP8B1 GPX4 FAAH2 CBR1-1 AWAT1 GGT1 ALOX15 ALOX12 DPEP2 CYP2C9;CYP2C19 DPEP1 CYP4B1 EPHX2 ALOX5 ALOXE3 CYP1A1 CYP1A2 CYP4F3;CYP4F2;CYP4F12;CYP4F11 PTGR2 FAAH GGT5 MAPKAPK2 PTGDS PTGS1 PTGS2-2 SLC27A1 PTGR1-1 CYP2U1 PTGES ABCC1 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%419812 Calcitonin-like ligand receptors CALCA RAMP1 ADM2 RAMP2 RAMP3 CALCB;CALCA CALCRL CALCR ADM IAPP REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity DIO1 DIO3 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.6 Integrin cell surface interactions ITGB1 ITGB5 ITGB8 ITGA2 LUM ITGA10 ITGAV COL16A1 ITGB6 CDH1 BSG VCAM1 ITGB2 COL23A1 HSPG2 COL13A1 F11R FN1 ITGA8 PECAM1 COL9A1 COL9A3 COL9A2 COL18A1 COL4A2 COL4A1 COL4A4 THBS1 COL4A3 JAM2 KDR JAM3 TNC ITGA6 COMP CD47 IBSP VTN ITGB3 ITGA11 FBN1 ITGAE FGB ICAM3 ITGAL FGA ICAM4 CD44 ICAM5 ITGAX FGG ITGA1 ITGA2B ITGB7 ITGA4 ITGA3 ITGAD ITGA7 ITGA5 SPP1 AGRN ITGAM ITGA9 ICAM2 ICAM1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation C1S C1R C1QC C1QB CRP PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 97%3215018 Processing and activation of SUMO RWDD3 SENP1 SUMO1 SENP5 SUMO3 UBE2I SUMO2 SENP2 UBA2 SAE1 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters SLC30A2 SLC39A10 SLC30A1 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC24A5 SLC39A7 SLC40A1 SLC39A2 SLC39A4 SLC39A1 SLC8A3 HEPH SLC39A3 SRI CALM3;CALM1 SLC8A1 SLC8A2 SLC30A10 SLC24A2 SLC24A3 SLC9A1 SLC8B1 SLC9A2 SLC24A1 SLC9A3 SLC24A4 SLC9A4 SLC30A8 SLC9A5 SLC30A5 CP SLC9A6 SLC9A7 SLC9A8 SLC31A1 SLC9A9 SLC41A2 SLC11A2 SLC41A1 SLC11A1 SLC30A3 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H POLR2L TBP BDP1 GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR1C GTF3C5 POLR1D BRF1 GTF3C6-1 CRCP G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK GNB3 GNGT1 GNB5 GNG10 GNG2 GNG5 GNG4 BTK GNG8 GNG13 GNB2 GNB1 GNB4 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A1 SLC13A4 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 97%72200 mRNA Editing: C to U Conversion APOBEC1 APOBEC2 A1CF CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle ESCO1 BUB1 FBXL18 ESCO2 CLASP2 AKT2 AKT3 CSNK2A1;CSNK2A3 PPP1CC GOLGA2 SFN CDC25A HMMR CDC25B PRIM2 PRIM1 POLA1 POLA2 RPS27 LPIN1 LPIN2 LPIN3 SKP2 YWHAE CEP57 CETN2 CEP164 CCP110 AKAP9-1 PPP1CB MAPRE1-1 PRKACA-1 ACTR1A TUBA1A LBR PPP2R1A CNTRL CEP250 NEK2 BTRC CEP290 YWHAG RAB8A SKP1 CDK5RAP2 HSP90AA1 OPTN-1 TERT HJURP CEP135 PPP1R12A RSF1 MIS18BP1 BORA OIP5 FBXW11 CENPW HAUS4 HAUS3 MIS18A CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 CEP63 AJUBA UBA52 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 PRKAR2B HAUS7 CEP70 CEP72 KIF20A CEP192 RPS27A PCNT CEP76 OBI1 LCMT1 CLASP1 UBB;UBC PPME1 CEP78 TICRR PLK4 OFD1-1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ RTEL1 ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E CEP41 CEP43 KIF18A ACD TINF2 ATRX TERF2 POT1 TERF2IP TERF1-1 IST1 SPAST CC2D1B DHFR2;DHFR JAK2 UBE2N KIF23 HSP90AB1 RAD51C TYMS KIF2A YWHAQ YWHAH KIF2C KIF2B CABLES1 CENPE WEE1 DKC1 NHP2 MAX LMNB1 NOP10 PPP2R2A;PPP2R2D TUBA1C TUBB1 E2F5 E2F6 TUBB2B;TUBB2A CCNE2 CCNE1 RB1 CCNH H2AC14 TUBB3;TUBB6 TUBAL3 TUBA3E;TUBA3C-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 CCND3 CCND2 KAT5 CHEK2 SMARCA5 CHEK1 CDKN2D DAXX CDKN2C HUS1 TUBA8 H2AC20 WRAP53 H2AB2;H2AB3;H2AB1 MYBL2 DNA2 RHNO1 PHF20 E2F4-1 TFDP1 PCBP4 TFDP2 RAB1A ATRIP RAB1B BARD1 PLK3 E2F1 CDC7 E2F3 TPX2 RAD17 ATM ATR CDKN1A CDKN1B BRCA1 H2AJ CDCA5 PDS5B PDS5A WAPL ESPL1 BABAM1 RMI2 BABAM2 FKBP6 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 CDKN2B H2BC5 PCNA WRN H2BC1 RPA1 PTK6 RPA2 CDK4 MLH1 CDK2 PTTG1;PTTG2 RPA3 EP300 PHLDA1 RAD1 H2AC4 CLSPN MRE11 KMT5A NBN CDK11A;CDK11B CDC25C CDK6 ABL1 BLM MDM2-2 NPM1-2 SPO11 SYCP1 CDK7 SYNE2 SYNE1 SUN1 TEX12 SMC1B MSH4 MNAT1 MSH5 DMC1 GSK3B SYCP3-2 KPNB1 RAD51 PSMC3IP SYCE2 SYCE1 MND1 HSPA2 MLH3 REC8 STAG3 SYCP2-1 MDM4 RAD9B H2BC21 RAD9A EXO1 H2AZ2;H2AZ1 TOPBP1 ZNF385A RFC5 RFC3 RFC4 RFC2 RBL2 RBL1 BIRC5 SMC3 AURKB RAD21 RBBP8 STAG1 HDAC1 STAG2 SMC1A RAD50 RBBP4 PRDM7;PRDM9 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E POLR2F POLR2H RBBP7 POLR2L POLE RFC1 LIN54 LIN37 H2BC15;H2BC3;H2BC11;H2BC12 LIN9 LIN52 LYN GINS1 GINS2 CDC45 MCM7 NSD2 MCM8 GINS3 POLD3 GINS4 MCM3 POLD4 MCM4 POLD2 MCM5 MCM6 MCM2 POLE4 MAPK1 POLE2 RUVBL2 POLE3 RUVBL1 BUB1B CDC20 FBXO5 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 C1orf112 PSMB6 BRCA2 PSMB7 PSMD6 PSMB4 PSMD7 FIGNL1 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 LEMD3 YWHAB XPO1 AKT1 TNPO1 NUP214 PRKCA YWHAZ ANKLE2 SET-1 MCM10 DBF4 MAPK14 MAPK11 PRKCB DYNC1LI1 DYNC1LI2 DSCC1 CHTF18 CTC1 RBX1 STN1 TEN1 CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 GTSE1 FKBPL CSNK1A1 NUF2 EMD NUDC INCENP CENPA CENPC E2F2 TP53BP1 CENPT TOP2A NUP107 CENPU NUP188 RCC1 BANF1 PPP6C NUP210 CENPF CENPH PPP6R3 RNF168-1 LIG1 GORASP1 CENPI NUP93 TAOK1 CHMP4C CENPK CHMP4B CHMP4A CENPL NUP205 USO1 CENPM NEK9 NEK6 AAAS NEK7 NEK11 CENPO ANKRD28 CENPP NUP160 NUP85 CENPQ TPR NUP88 PIF1 NUP155 SHQ1 SUN2 NUP153 POLR2J;POLR2J2;POLR2J3 CHMP2B CHMP2A RRM2-1 CLIP1 FEN1 MAD1L1 BRIP1 NUP62 CDKN1C NDC1 SEC13 NUP133 NDC80 RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 NUMA1 CHMP7 TUBG2 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 VPS4A TUBGCP4 POLR2A SPDL1 NUP42 POLR2B POLR2C POLR2D NUP43 POLR2G POLR2I RAE1 RANBP2 NSL1 CENPX NUP35 RAN NUP37 GMNN ORC5 COP1 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 KNL1 ZW10 DSN1 EML4 RCC2 ZWINT CDC14A AHCTF1 HERC2 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E FOXM1 VRK1 LEMD2 CTDNEP1 CNEP1R1 FBXL7 RAB2A GORASP2 BLZF1 SMC4 DYNC1I1 SMC2 NCAPG NCAPH NCAPD2 PIAS4 UBE2I DYRK1A POLD1 CKS1B PPP2R3B B9D2 SPC24 SPC25 PKMYT1 ERCC6L ARPP19 NCAPH2 SUMO1 NCAPG2 ZWILCH NIPBL ENSA SIRT2 NCAPD3 PMF1;PMF1-BGLAP MAU2 MASTL MCPH1 TP53 KNTC1 SGO1 UBE2V2 SGO2 MYC CENPS-CORT;CORT;CENPS CSNK2A2 CCND1 CSNK2B ANAPC15 ANAPC16 TK1 UBE2D1 ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 ANAPC7 CDKN2A UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines PAOX CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants NOTCH1 ADAM17 MIB2 DLL1 JAG2 DLL4 RPS27A NEURL1 UBB;UBC NEURL1B MIB1 JAG1 UBA52 ADAM10 RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle BCR ARHGEF5 STOM DAAM1 IQGAP3 FMNL3 FMNL2 ABR STARD13 JUP CAVIN1 MCAM CAV1 MYO9B ACBD5-1 DLC1 ARHGAP1 TJP2 RTKN ROCK2 ARHGAP39 CIT IQGAP1 ARHGDIA VAMP3 PKN3 ARHGEF40 PIK3R1 ROCK1 LMAN1 ARHGAP5 ARHGAP21 ARHGEF25 FLOT2 ARHGEF28 STX5 LBR ARHGAP18 OPHN1 TMPO ARHGAP35 MCF2 VANGL1 RHOA DEPDC1B MACO1 ARHGAP26 DIAPH1 ARHGAP32 PKN2 VAPB PKN1 ANLN DIAPH3 ARHGEF10L AKAP13 C1QBP MCF2L STK10 FLOT1 SLK ARHGEF11 ARHGEF10 ARHGEF12 ABCD3 ARHGEF17 TFRC RHOC ERBIN VAV2 PREX1 CCDC187 ARHGEF1 RACGAP1 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 97%381426 Regulation of IGF Activity by IGFBP FGF23 P4HB APOB APOL3;APOL4;APOL1;APOL2 MSLN BPIFB2 SDC2 MFGE8 CST3 APP DNAJC3-1 IGFBP7 WFS1 PNPLA2 ALB DMP1 CALU ANO8 VCAN MATN3 SPP2 MELTF AHSG PDIA6 TNC APLP2 APOA2 APOA1 SCG3 CKAP4 KTN1 APOA5 LOC110384692;C4A;C4B_2;C4B FBN1 GPC3 CP KLK13 CSF1 IGFBP1 LAMB2 MEN1 LTBP1 IGFBP3 HSP90B1 TF CHRDL1 PENK QSOX1 MBTPS1 MIA3 FSTL1 FSTL3 ADAM10 IGF2 PRKCSH MGAT4A-1 GZMH-1 BMP4 FN1 IGF1 LAMC1 C3-1 KLK3;KLK2 CTSG TIMP1 LGALS1 AMELY;AMELX SERPINA1 EVA1A CCN1 CHGB IGFBP5 MMP1 IGFBP4 MMP2 IGFBP2 SHISA5 PAPPA MXRA8 SPARCL1 IGFALS SCG2 KLK1 STC2 IGFBP6 AMBN TMEM132A HRC FGA PRSS23 BMP15-1 FGG MEPE F2 RCN1 ENAM NOTUM F5 AMTN VWA1 FAM20C PLG FAM20A PAPPA2 ITIH2 SERPINC1 AFP SPP1 KNG1 GOLM1 VGF SERPIND1 NUCB1 LAMB1 FUCA2 TGOLN2 PROC CDH2 IL6 APOE PCSK9 GAS6 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%4419969 Depolymerization of the Nuclear Lamina CDK1 PRKCA EMD CCNB1 LEMD3 LPIN1 LPIN2 LPIN3 LMNB1 LEMD2 CTDNEP1 CNEP1R1 PRKCB XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics ARNT2 AHRR AHR CYP2C18-1 CYP2S1 CYP2D6;LOC107987479;LOC107987478-1 CYP2F1 CYP2C9;CYP2C19 CYP2A13;CYP2A6;CYP2A7-1 CYP2J2-1 CYP1A1 CYP1A2 ARNT CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 CYP2W1 CYP2B6 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME DATABASE ID RELEASE 97%9912529 H139Hfs13* PPM1K causes a mild variant of MSUD DLD BCKDHA PPM1K DBT BCKDHB NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus NGF PSEN1 RPS27A PSENEN NCSTN PSEN2 TRAF6 UBB;UBC APH1A APH1B NGFR SQSTM1 ITGB3BP MAPK8 UBA52 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.3 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHB-1 HADHA HADH ACADM ECHS1 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME DATABASE ID RELEASE 97%5682294 Defective ABCA12 causes ARCI4B ABCA12 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 97%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) MVD HELZ2 MED1 MVK HMGCS1-1 TM7SF2 MBTPS1 SCAP MBTPS2 KPNB1 SAR1B TGS1 CREBBP SP1 PMVK INSIG2 INSIG1 SREBF2 RXRA GPAM CARM1 PPARA NFYA-1 DHCR7 RAN SEC23A NFYB NFYC NCOA1 NCOA2 NCOA6 SMARCD3 SEC24B SEC24A GGPS1 SEC24C IDI1 FDFT1 SQLE ACACB ACACA CYP51A1 ELOVL6 SCD FDPS SEC24D-1 MTF1 CHD9 TBL1XR1 FASN LSS SC5D FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 97%111458 Formation of apoptosome APAF1 UACA AVEN DIABLO-1 CASP9 MAPK1 MAPK3 CYCS-1 APIP XIAP PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PDGFRA PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163358 PKA-mediated phosphorylation of key metabolic factors PFKFB1 PRKACB-1 PRKACA-1 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 SUPPRESSION OF APOPTOSIS%REACTOME%R-HSA-9635465.2 Suppression of apoptosis GSK3A TRIM27 MAPK1 CTSG MAPK3 SFPQ-1 RNF213-2 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein GSK3A PARP9 SUMO1 SRPK2 PARP8 PARP16 PARP14 SRPK1 PARP10 GSK3B UBE2I PARP6 PARP4 PRMT1 CSNK1A1 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) FEN1 RAD52 RAD50 POLQ MRE11 PARP2 NBN LIG3 BRCA2 RBBP8 XRCC1 PARP1 TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656532 TGFBR1 KD Mutants in Cancer TGFBR1-1 TGFBR2 SMAD2;SMAD3 TGFB1 DISEASES OF DNA REPAIR%REACTOME%R-HSA-9675135.6 Diseases of DNA repair MSH2 BLM RAD51 RAD9B KAT5 RAD51B RAD9A NEIL3 RAD51C NEIL1 HUS1 EXO1 NTHL1 BRCA2 TOPBP1 DNA2 RAD51AP1 RHNO1 RFC5 RFC3 RFC4 XRCC2 RFC2 PALB2 ATRIP MSH6 MSH3 BARD1 RBBP8 OGG1 SEM1 RAD17 ATM RAD50 ATR BRCA1 RMI2 RMI1 TOP3A RAD51D WRN PMS2 RPA1 RPA2 MLH1 RPA3 RAD1 BRIP1 MRE11 NBN REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME%R-HSA-9759476.1 Regulation of Homotypic Cell-Cell Adhesion CSNK2A1;CSNK2A3 MOGS H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A RPN2 SEC11C RPN1 PSMD12 PSMD11 PSMD14 PSMD13 SMARCA4 FOXA2 H2AC20 PSMA7 PSMD8 H2AB2;H2AB3;H2AB1 SRC EZH2 PSMB6 TGIF2 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 ZC3H12A PCSK7 SPCS3 PSMD3 ANK3 SPCS2 PSMB1 SPCS1 PSMD1 BANP ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CTNND1 PSMC6 MTBP PSMA4 RACK1 CBLL1 SIRT1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 H2AJ TCF12 ADAM33 CANX CDH8 PCSK6 TLE1 ADAM19 ANGPTL4 CDH24 SUZ12 H2BC5 UBA52 H2BC1 SOX10 KDM1A CDH19 DNM2 MPHOSPH8 PRDM8 HEYL ILF3 FOXF1 BHLHE22 HOXC8 RPS27A H2AC4 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 KMT5A PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 MDM2-2 SNAI1 SNAI2 CTNNA1 CDH1 KLF4 OST4 JUP STRAP OSTC STT3A TWIST2 SP1 H2BC21 VCL PRKCSH EED DDOST H2AZ2;H2AZ1 WT1 ARID1A DAD1 GANAB MYC CTSS HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 CDH11 AGO3;AGO1 ZNF217 TNRC6B CTSB CTSV;CTSL H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 FURIN ZMYM2 CTBP2 CTBP1 MAPK1 POMT2 RB1 MAPK3 POMT1 H2AC14 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation ITPR1 PRKCD ITPR2 PRKCA ITPR3 KDR PDPK1 PRKCZ AHCYL1 CALM3;CALM1 SPHK1 PLCG1 HRAS RASA1 PRKCB NRAS SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 97%445144 Signal transduction by L1 ITGA2B ITGB1 CSNK2A2 ITGA5 L1CAM PAK1 RAC1 CSNK2A1;CSNK2A3 ITGAV CSNK2B MAP2K2;MAP2K1 ITGA9 NRP1 EGFR VAV2 MAPK1 ITGB3 MAPK3 NCAM1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars SLC35D1 SLC35B3 SLC35D2 SLC35B2 SLC35B4 SLC35A1 SLC35A2 SLC35A3 SLC35C1 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis LTF PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964043 Plasma lipoprotein clearance SOAT1 SOAT2 NR1H3 NPC2 APOC1 APOC4 APOB APOA1 LIPC VLDLR NR1H2 CLTC CLTA AP2A1 UBA52 AP2B1 AP2A2 LDLRAP1 AP2S1 MYLIP RPS27A CES3 CUBN APOBR UBB;UBC LDLR APOE PCSK9 HDLBP LSR LIPA AMN NCEH1 NPC1-1 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 97%426048 Arachidonate production from DAG DAGLA ABHD6 ABHD12 DAGLB MGLL METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins S100A8 S100A7A;S100A7 LTF LCN2 S100A9 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8853383 Lysosomal oligosaccharide catabolism MAN2B2 MAN2B1 MANBA MAN2C1 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 97%211999 CYP2E1 reactions CYP2S1 CYP2D6;LOC107987479;LOC107987478-1 CYP2F1 CYP2C9;CYP2C19 CYP2A13;CYP2A6;CYP2A7-1 CYP2E1 CYP2B6 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 97%9953080 MPS VII - Sly syndrome (CS DS degradation) GUSB SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 97%446219 Synthesis of substrates in N-glycan biosythesis DPM1 DPM2 MVD DPM3 ST8SIA5 ST6GAL1 CTSA MPI ST3GAL4 ST6GALNAC2 DOLK ST3GAL1 ST3GAL2 ST3GAL3 SLC35A1 SRD5A3 SLC35C1 ST6GALNAC1 CMAS NPL NANP ST6GALNAC3 ST6GALNAC4 NEU4 NAGK AMDHD2 ST8SIA4 NANS GFPT2 ST6GAL2 GFPT1 PGM3 ST8SIA1 GNPNAT1 GNE UAP1 RENBP ST3GAL6 ST6GALNAC5 GLB1 ST6GALNAC6 ST3GAL5 ALG5 NUDT14 DHDDS PMM2 GMPPB FPGT GMPPA GFUS DHRSX GMDS ST8SIA6 NUS1 PMM1 ST8SIA2 FCSK DOLPP1 ST8SIA3 HK1 NEU2 NEU3 SLC17A5 NEU1 FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654712 FRS-mediated FGFR4 signaling FRS2 FGF20 SOS1 FGF23 PTPN11 FGF2 KLB FGF19 FGFR4 HRAS FGF1 FGF6 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 97%193639 p75NTR signals via NF-kB NGF MYD88 RELA IRAK1 RPS27A PRKCI TRAF6 NFKB1 UBB;UBC IKBKB NGFR SQSTM1 RIPK2 NFKBIA UBA52 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases PTK2B AKT2 AKT3 PDE3B IDE PTPRF PIK3R4 STAT6 STAT5A STAT5B RAB4A EGF ERBB2 PLCG1 ADORA2A NRP1 EGFR PDGFRA TIAL1 FGF6 PTBP1 RBFOX2 ESRP2 RAP1B HNRNPH1 ESRP1 PRKACA-1 HGF HNRNPA1-1 DOCK7 TIA1 GAB1 HNRNPM MET PPP2R1A CTNND1 AREG EPS15 PRKCE HSP90AA1 FGF7 FGFBP1 FGFBP3 PCSK6 FGF22 FGF3 FGF10 UBA52 STAT1 ATF1 RPS27A ELK1 RPS6KA3 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MEF2A MEF2C MAPKAPK3 TNS4 TNS3 SPINT1 HPN MST1 MST1R SPINT2 STAT3 ITGA2 DOCK3 GRIN2B INS;INS-IGF2 CAV1 MEMO1 JAK2 FLT3 TAB2 ADAM10 ADAM17 PDPK1 PSEN1 NCSTN CDC42 PIK3C3 SH2B3 SH2B2 COL9A1 COL9A3 COL9A2 PLAT LAMC2 LAMC1 PTPN11 CTSD PTPRJ HGS CALM3;CALM1 ATP6V1H MMP9 PAK2 LAMA5 GABRB3 THBS4 GABRB2 LAMA3 THBS3 PDGFD GABRB1 FURIN RALA-1 PLG HNRNPF SPP1 YAP1-1 LAMB3 CMA1 LAMB1 GABRG3;GABRG2 SPHK1 FLT4 STUB1 GABRQ TGFA GABRA1 NOS3 YES1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 VEGFA SHC2 RALGDS PTPRO ATF2 RALB MAPK13 RIT1 SGK1-1 RIT2 CHEK1 CDH5 MAPKAP1 JUNB ARF6 GGA3 VEGFB VEGFC VEGFD MAPK7 MAP2K5 RAC1 TCF12 NRG1 NCOR1 NRG2 RHOA EREG BTC NRG3 NRG4 ELMO1 ELMO2 CRK FOS DOCK1 HBEGF WWP1 PXN CBL RICTOR NTF3 PTPN1 PTK6 ID1 BCAR1 EP300 GFAP PSEN2 APH1A APH1B DNMT1 ADCYAP1 ADCYAP1R1 FLRT2 FLRT3 FLRT1 ITGAV CDK5 PSENEN CHD4 SIN3A PGF FLT1 SHB THEM4 PRR5 MLST8 SOCS6 JUND HDAC2 HDAC3 THBS1 CXCL12 HDAC1 MTOR BAX FOSB PCSK5 POLR2E POLR2F POLR2H SHC1-1 POLR2L ITGB3 LYN HGFAC NTRK2 TIAM1 BDNF CDK5R1 F3 AHCYL1 MAP2K2;MAP2K1 RAP1A RAPGEF1 MAPK1 BRAF MAPK3 CRKL FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 INSR GRB10 PIK3R3 COL4A5 THBS2 GALNT3 MUC20 REST RANBP10 ROCK1 PTPRK EPS15L1 EPN1 COL4A2 ADAM12 COL4A1 LRIG1 COL4A4 FAM83D TEC AAMP COL6A2 PAG1 COL4A3 FAM83B FAM83A COL6A1 SPRY1 PTPN3 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 COL6A3 CTNNB1 COL6A6 IRS4 COL6A5 RAB4B ATP6V0D1 ATP6V0D2 YWHAB ATP6V1A HSPB1 KIT NTRK3 AKT1 ATP6V0A2 PRKCD ATP6V0A4 PRKCA ATP6V1D MAPKAPK2 ATP6V1C1 ATP6V1F ATP6V0A1 CYFIP2 ATP6V1C2 CYFIP1 NCKAP1 WASF1-1 MAPK14 MAPK11 TCIRG1 PRKCB ATP6V0B MEF2D FLT3LG PDGFB PTPN2 ATP6V1B2 EGR1 ATP6V0C ATP6V1B1 ANOS1-1 GRAP2 GAB2 PRKCZ KLB NCKAP1L PDGFRB LTK JUP TNK2 FGF19 ATP6V1G3 FGFR4 PRKACB-1 ATP6V0E2;ATP6V0E1 ITCH IGF1 SPRED2 CILP CSN2-1 SPRED1 GRAP HRAS FYN RASA1 MXD4 PTPRU MKNK1 STMN1 SPRY2 NRAS ADAP1 FER KDR KIDINS220 TLR9 ABI2 GTF2F1 GTF2F2 GRB2 TGFBR3 GIPC1 ABI1 IGF1R EPGN NCF1 NCF2 NCF4 POLR2J;POLR2J2;POLR2J3 SHC3 TRIB3 FES NELFB APOE MAPK12 USP8 PTPN18 NCBP1 MATK NRP2 NCK2 POLR2A IRS2 NCK1 POLR2B POLR2C POLR2D SOCS1 POLR2G ITPR1 POLR2I ITPR2 LCK ITPR3 ROCK2 SRC SRF NCBP2-1 LAMA1 CSK SPARC WASF2 WASF3 BAIAP2 PTPRS GRB7 STAM LAMC3 NTRK1 CLTC PTK2 CLTA AP2A1 AP2B1 NGF AP2A2 DNM1 DNM2 ITGA3 DNM3 AP2S1 DNAL4 SH3GL2 PPP2CB;PPP2CA LAMA2 LAMA4 LAMB2 VAV3 PPP2R5D PPP2R1B CDC37 ERBIN VAV1 VAV2 ARHGEF7 ITGB1 PAK1 FGF2 CTNNA1 PAK3 NEDD4 FGFRL1 SH3GL3 SH3GL1 ESR1 IGF2 PGR ID4 ALK CD274 IRS1 PIK3R2 PIK3CB PTN PRDM1 CYBB RNF41 PIK3R1 CYBA IL2RG HIF1A PTPRZ1 CUL5 MDK MYC STAM2 ALKAL2 ALKAL1 TPH1 JAK3 FRS2 MYCN PIK3CA PTPN6 RANBP9 DIAPH1 WWOX DLG4 PTPN12 NAB1 NAB2 LYL1 ARC SH3KBP1 ATP6AP1 VGF TRIB1 RRAD ASCL1 EGR2 EGR3 EGR4 FOSL1 ID3 CDK5R2 ID2-1 AXL SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET USP8 SPINT1 SOS1 HPN SPINT2 PTPN2 ITGB1 STAT3 ITGA2 SH3GL3 SH3GL1 MUC20 RAB4A SRC RANBP10 LAMA1 ARF6 HRAS PIK3R1 LAMC2 LAMC1 STAM2 GGA3 RAP1B NRAS LRIG1 HGF DOCK7 GAB1 PIK3CA MET PTPN11 EPS15 RANBP9 RAC1 PTPRJ HGS RAB4B CRK LAMC3 STAM HGFAC PTK2 UBA52 CBL LAMA5 ITGA3 LAMA3 PTPN1 SH3GL2 LAMA2 LAMA4 SH3KBP1 LAMB3 LAMB2 RPS27A LAMB1 UBB;UBC RAP1A RAPGEF1 CRKL TNS4 TNS3 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane STX5 VAMP2 STX1A APP EMD HMOX1 UBL4A CAMLG SGTA BAG6 GET1 GET3 SEC61G GET4 SEC61B OTOF VAPA PRNP AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 97%349425 Autodegradation of the E3 ubiquitin ligase COP1 PSMA6 PSMC5 ATM PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC TP53 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 COP1 PSMC2-1 PSMA2-1 PSMA5 SEM1 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%162588 Budding and maturation of HIV virion PDCD6IP VPS37C VPS37D VPS37A VPS37B CHMP3 CHMP6 CHMP7 CHMP5 VPS4B CHMP4C VPS4A CHMP4B CHMP4A VPS28 TSG101 NEDD4L MVB12B MVB12A UBA52 VTA1 CHMP2B RPS27A CHMP2A PPIA UBAP1 UBB;UBC UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CCND1 GSK3B UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 CDK4 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 97%9709603 Impaired BRCA2 binding to PALB2 KAT5 ATM RAD51B RAD50 RAD51C BLM EXO1 BRCA1 BRCA2 RAD51AP1 DNA2 XRCC2 PALB2 RMI2 BRIP1 RAD51 MRE11 RMI1 TOP3A BARD1 NBN RAD51D RBBP8 WRN REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide CA13 CA5B CA12 CA1 CA5A CA3 CA2 CA4 CA7 CA6 CA9 CA14 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167238 Pausing and recovery of Tat-mediated HIV elongation CCNT1 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I SUPT4H1-1 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 TCEA1 ELL ELOC-1 ELOA NELFB ELOB NELFCD NELFA NELFE ERROR-PRONE MISMATCH REPAIR HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9968295.1 Error-prone mismatch repair hypermutates immunoglobulin genes MSH2 POLH PMS2 MLH1 EXO1 POLD3 POLD2 RFC5 RPS27A RFC3 RFC4 RFC2 UBB;UBC REV1 RFC1 MAD2L2 MSH6 REV3L PCNA UBA52 POLI OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.8 Oxidative Stress Induced Senescence CDK6 MAPKAPK5 MINK1 TXN MDM2-2 MAP2K6 BMI1 KDM6B RING1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDM4 H2BC21 RNF2 CDKN2D CDKN2C CBX8 H2AC20 TNIK CBX6 EED PHC2 H2AB2;H2AB3;H2AB1 PHC1 H2AZ2;H2AZ1 EZH2 CBX4 CBX2 PHC3 TP53 TFDP1 TFDP2 E2F1 E2F3 IFNB1-4 E2F2 JUN MAP4K4 TNRC6C MOV10 TNRC6A-1 RBBP4 AGO4 AGO3;AGO1 H2AJ TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 FOS H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 CDKN2B H2BC5 UBA52 H2BC1 MAPKAPK2 CDK4 RPS27A CDKN2A MAP3K5 H2AC4 UBB;UBC MAP2K3 MAPK1 MAPK14 MAP2K4 MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 H2AC14 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176034 Interactions of Tat with host cellular proteins CCNT1 CDK9 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9013508 NOTCH3 Intracellular Domain Regulates Transcription NOTCH1 HES1 STAT1 SNW1 PLXND1 MAMLD1 RBPJ FABP7 WWC1 PBX1 KAT2B HEYL DLGAP5 PTCRA KAT2A MAML2 EP300 MAML1 HES5 MAML3 NOTCH3 HEY1 CREBBP HEY2 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111448.5 Activation of NOXA and translocation to mitochondria TP53 TFDP1 TFDP2 PMAIP1 E2F1 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1-1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation TICAM2 LY96 TICAM1 RPS27A IRAK2 TRAF6 CD14 UBB;UBC MAP3K7 TLR4 TAB3 TAB2 UBA52 TAB1 VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.6 VEGFA-VEGFR2 Pathway PTK2B AKT2 NOS3 AKT3 PAK1 ITGAV PRKCZ CTNNA1 PAK3 NCKAP1L JUP NCK2 CAV1 NCK1 SHC2 PRKACB-1 MAPK13 SHB ITPR1 THEM4 ITPR2 PRR5 ITPR3 CDH5 PDPK1 ROCK2 MLST8 CDC42 MAPKAP1 PIK3R2 PIK3CB PLCG1 HRAS CYBB CYBA PIK3R1 RASA1 FYN WASF2 WASF3 ROCK1 NRAS BAIAP2 PRKACA-1 PIK3CA CTNND1 MTOR KDR CTNNB1 RAC1 HSP90AA1 RHOA ABI2 CALM3;CALM1 ELMO1 ABI1 ITGB3 ELMO2 CRK HSPB1 DOCK1 PTK2 AKT1 PAK2 PXN NCF1 PRKCD RICTOR PRKCA NCF2 NCF4 MAPKAPK2 BCAR1 CYFIP2 CYFIP1 NCKAP1 VAV3 TRIB3 WASF1-1 AHCYL1 SPHK1 VAV1 VAV2 MAPK14 MAPK11 MAPKAPK3 MAPK12 AXL PRKCB DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 97%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 PRELP ST3GAL3 OMD ACAN KERA FMOD LUM OGN COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.5 Collagen degradation CTSK CTSD CTSB COL16A1 CTSV;CTSL MMP7 COL12A1 COL25A1 MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 MMP12 MMP11 MMP14 MMP13 MMP15 PHYKPL COL23A1 MMP19 ADAM10 COL15A1 ADAM17 TMPRSS6 FURIN ADAM9 COL17A1 COL19A1 COL13A1 COL26A1 PRSS3;PRSS2;PRSS1 ELANE COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 MMP20 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex DLD PDK4 DLAT PDPR PDK3 PDK2 PDHB PDK1 PDHX GSTZ1 PDHA1 SIRT4 PDP1 PDP2 CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle SLC25A20 THRSP CPT1A MID1IP1 PPARD RXRA CPT1B PRKAB2 PRKAA2 PRKAG2 SLC22A5 CPT2 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin HSP90AB1 HBEGF HSP90AA1 CD9 EEF2 TXNRD1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 97%109704 PI3K Cascade FGF20 FRS2 GAB1 FGF23 FLT3LG PIK3CA PTPN11 AKT2 GAB2 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 FGF10 FGF19 FGFR4 IRS2 FLT3 PIK3R4 THEM4 PDPK1 TRIB3 IRS1 PIK3C3 PIK3R2 PIK3CB PIK3R1 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 RETINOID METABOLISM DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%6809583 Retinoid metabolism disease events RBP4 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 EIF3C;EIF3CL RPL31 EIF1AY;EIF1AX RPL34 EIF3M RPL27A EIF3K RPL8 EIF3L EIF3I RPL9 EIF3J RPL6 EIF3G EIF3H RPL7 EIF3E EIF3F RPS4X EIF3D EIF3A RPL35 EIF3B RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 97%9839406 TGFBR3 regulates activin signaling INHA TGFBR3 INHBA ACVR2A TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 97%168176 Toll Like Receptor 5 (TLR5) Cascade UBE2V1 MAP2K6 IRAK1 IRAK2 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 UBE2N ATF2 TAB3 TAB2 TAB1 APP NFKB2 TRAF6 TLR5 TP53 NOD1 NOD2 RIPK2 ALPK1 NLRX1 AGER S100A12 N4BP1 JUN PPP2R1A USP18;USP41 MYD88 MAPK7 NFKBIB SAA2;SAA1 NKIRAS1 BTRC NKIRAS2 IKBIP IRAK4 ECSIT SKP1 TRAF2 PELI1 CHUK CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 FBXW11 TIFA HMGB1-1 MAP3K1 IKBKB IKBKG FOS UBA52 NFKBIA CUL1 MAPKAPK2 RELA TLR10 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC NFKB1 RPS6KA1 MAP3K7 MAP2K2;MAP2K1 MAP3K8 MEF2A MAP2K3 MAPK1 MAPK14 MAP2K4 MEF2C MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358747 CTNNB1 S33 mutants aren't phosphorylated PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis PPA1-1 PPA2 LHPP RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 97%749476 RNA Polymerase III Abortive And Retractive Initiation POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H SSB NFIX POLR2L NFIA NFIB NFIC ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 BRF2 TBP BDP1 POU2F1 GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR1C GTF3C5 POLR1D BRF1 GTF3A GTF3C6-1 CRCP SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839117 Signaling by cytosolic FGFR1 fusion mutants CPSF6 BCR STAT1 PIK3CA CEP43 MYO18A LRRFIP1 STAT5A STAT3 FGFR1OP2 STAT5B TRIM24 GAB2 ZMYM2 PIK3R1 CUX1 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing PABPN1-1 CPSF4 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD MAT1A VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways DPM1 DPM2 DPM3 DNAJC10 ELAVL2 GBP2;GBP3;GBP1 CSNK2A1;CSNK2A3 RPL10A S1PR1 PPP1CC VIM RAB5A EGFR RPL36AL-1 YWHAE PPP1CB PRKG2 NEK2 BTRC YWHAG APOA1 SKP1 HSP90AA1 CDC73 LEO1 UBA52 DYNC1I2 RPL18A RPS27A ELK1 UBB;UBC DYNC1H1 TUBB4A;TUBB;TUBB8B;TUBB8 BCL2L1 HSPG2 ACOT2;ACOT1 COMT RPL15-1 CTSV;CTSL MMP9 ITGA4 FURIN RB1 CCNH H2AC14 TRIM28 MED1 MED4 MED6 MED7 CCNC-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP SMAD2;SMAD3 H2AC20 EZH2 RPL10;RPL10L-1 MED16 MED17 MED12 MED14 MED13 MED10 MED27 ARF1 MED23 RPLP0 NCOR2 NCOR1 RPLP2 MED24 TAL1 RPL36-1 MED20 GPS2 SF3B1 MBD3 SUZ12 H2BC5 H2BC1 GTF2H1 GTF2H3 GTF2H4 GATAD2B GATAD2A MED31-1 ARID4B EP300 NRBP1 H2AC4 SAP30 TBL1XR1 MED30 SUDS3 RPL22L1 CDK8 CDK7 RPL37A-1 MNAT1 GSK3B KPNB1 PSIP1 CHD4 CHD3 H2BC21 PARP1 TBP EED SMAD4 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 CAMK2B CAMK2D HDAC2 CAMK2A RPL13A-1 HDAC3 SLC25A4 HDAC1 CAMK2G MTA1 RBBP4 SAP30L H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L PROS1 H2BC15;H2BC3;H2BC11;H2BC12 ERCC3 ERCC2 F2 CLU RPL23A EIF2AK2 TLR1 TLR2 CD4 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 IPO5 GRSF1 PSMA7 DNAJC3-1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 IFIT1 IFIT3 ADRM1 IFIT2 VPS36 SNF8 VPS25 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PPP1CA PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 ATP1B2 ATP1B1 YWHAB HSPA1A;HSPA1B ELAVL1 XPO1 AKT1 NUP214 YWHAZ XRN1 FXYD4 FXYD3 FXYD1 HSPA8 PABPC1;PABPC3 FXYD6 EIF4G1 RBX1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 RPL26L1 RPL4 RPL30 RPL3 RPL32 ATP1B3-1 RPL31 FXYD2;FXYD6-FXYD2 RPL34 CSNK1A1 RPL8 RPL9 RPL6 ITCH RPL7 RPL35 RPL38 FKBP1A RPL39 CYSLTR1 SYK RPL21 HCK RPL23 RPL22 MED8 FYN MED9 CUL3 RPL24 RPL27 RPL26 RPL29 RPL28 NFKBIB CCNK NUP107 NUP188 CCNT1 GTF2B RCC1 PLCG2 BANF1 TLR9 KPNA1 SUPT16H NUP210 CDK19 LIG1 LIG4 RPL3L GTF2F1 GTF2F2 NUP93 CHMP4C CHMP4B CHMP4A VPS28 NUP205 TSG101 NEDD4L RPLP1-2 AAAS GTF2E1 GTF2E2 NUP160 NUP85 CLINT1 TPR NUP88 AP1G1 SUPT4H1-1 XRCC6 AP1S2 NUP155 AP1S1 XRCC4 AP1S3 XRCC5 VTA1 NUP153 AP1B1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CHMP2B CCNT2-1 NMT1 RAB5C CHMP2A NMT2 TAF4B FEN1 ELL ELOC-1 TAF7L NUP62 RPL11 ELOA RPL14 AP1M2 NELFB ELOB RPL13 NELFCD RPL18 AP1M1 NELFA RPL17 CCR5 RPL19 NELFE NDC1 SEC13 PDCD6IP NCBP1 NUP133 VPS37C VPS37D VPS37A VPS37B RANGAP1 NUP50 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 CHMP5 GTF2A1 GTF2A2 CTDP1 RNMT VPS4B TAF9 VPS4A CXCR4 POLR2A NUP42 POLR2B POLR2C MVB12B POLR2D MVB12A NUP43 POLR2G TAF9B POLR2I RAE1 RANBP2 RANBP1 TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 TAF7 UBAP1 NUP35 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 NUP37 RPL7A CHUK UBA7 HSPA5 DDX58 ISG15 RPL35A UBE2L6 HERC5 IFIH1 IKBKB IMPDH1 TRIM25 IMPDH2 ARIH1 IKBKG CLTC CLTA AP2A1 AP2B1 KEAP1 AP2A2 AP2S1 ATG7 ITGB1 SCAP PIK3R1 CUL5 UBA6 UBA5 JAK3 UBR4 PTPN6 TGFB1 RUNX1 UBA3 UBA1 RELA NFKB1 PATJ ZDHHC5 ZDHHC8 ZDHHC2 ZDHHC3 RPS15 RPS14 GJA1 RPS17 TBK1 RPS16 SNRPD2 RPS19 SNRPD1 RPS18 AKT2 AKT3 SNRPD3 RPS11 B2M RPS10 VPS39 RPS13 PTGES3-1 RPS12 MAP1LC3B2;MAP1LC3B-1 VPS18 ST6GAL1 MOGS ATG14 ACE2 SDC4 RPN2 SAR1B SDC2 SDC3 RPN1 PIK3R4 VPS11 ST3GAL4 SNRPE-2 SFN RIPK3 ST3GAL1 ST3GAL2 ST3GAL3 VPS16 SRPK2 MLKL EDEM2 PARP16 PYCARD PARP14 SRPK1 PARP10 RPS25 RPS27 CASP1 RPS29 SDC1 RPS20 RPS21 RPS24 RPS23 NRP1 MAGT1 IKBKE JAK1 TOMM70 PARP6 PTBP1 PARP4 PRMT1 RIPK2 SFTPD HNRNPH1 ANO8 ANO9 HNRNPA1-1 ANO6 HNRNPM TYK2 ANO4 PARP9 IL17RC NFE2L2 ANO5 ANO2 PARP8 IL17RA ANO3 ANO1 EEF1A1 SIKE1 SMN2;SMN1 CANX TLR8 TLR7 ZDHHC20 TMPRSS2 RPS27L RNF135 RPS15A GPC1 MGAT5 RPS3 GPC3 ANO10 GPC2 GPC5 MGAT1 GPC4 RPS2 MGAT2 GPC6 STAT1 KDM1A STAT2 SEC24D-1 MPP5 TJP1 NLRP12 ZDHHC9 STING1 IL17F FAU AGRN VCP-1 CRB3 IL17A TUSC3 GEMIN2 KPNA2 MAP3K7 RPS9 RPS7 RPS8 RPS5 VPS33A PHF21A RPS6 VPS33B RPSA ZCRB1 GOLGA7-1 TUFM TMEM258 GEMIN4 GEMIN5 GEMIN6 MASP1 SNRPF UBE2V1 GEMIN7 GEMIN8 ISCU RCOR1 IFNAR1 SNRPB DDX5 FUT8 TKFC IRAK1 IRAK2 MAN2A1 G3BP1 G3BP2 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 UVRAG HMG20B CAV1 MAVS OSTC STT3A JAK2 UBE2N TAB3 TAB2 STT3B TAB1 GSK3A ST6GALNAC2 HSP90AB1 PRKCSH MGAT4A-1 RPS4X YWHAQ YWHAH PDPK1 RPS3A DDOST LARP1-1 IRF3 DOCK2 DAD1 TRAF3 MBL2-1 TRAF6 IRF7 PIK3C3 MAN1B1 ST6GALNAC3 ST6GALNAC4 BECN1 SEC23A DDX20 NOD1 NOD2 GANAB EIF4A2 SNRPG-2 EIF4A1 VHL CNBP-1 SEC24B IFNB1-4 SEC24A GALNT1 PTPN11 MGAT4C VPS41 MGAT4B VPS45 SEC24C EIF4E ATP6V1H PABPN1-1 PAK2 HNRNPF HNRNPA2B1 SNRPA1 DAXX MAPKAP1 SNW1 RAC1 RPTOR EXOC1 ELMO1 GBF1 RICTOR NPLOC4 UFD1 FASN U2AF1L5;U2AF1 EIF4A3 NPM1-2 CDC40 SRRM1 SRSF2 SRSF3 SRSF5 SRSF6 SRSF7 SRSF9 SRSF1 U2AF2 PRR5 DHX38 SRSF11 SRSF4-1 ALYREF MLST8 RNPS1 CBX1 FKBP4 PML MTOR TLR3 LY96 RIPK1 CD14 TLR4 LYN NFKBIA H2AC16;H2AC11 ARID4A SOS1 BRMS1 IFNGR1 IFNGR2 P4HB H2BC18 REST SLC25A5 SLC25A6 ROCK1 MED19 MED15 MED18 MED11 PPIB MED26 MED29 MED22 MED25 MED21 P4HA1 RBMX P4HA2 P4HA3 RPL12-1 DYNC1LI1 DYNC1LI2 CD28 HNRNPC SP1 KPNA4-1 HYOU1 CPSF2-1 ATL2 CRBN NUDT21 FNTA LY6E FUS NACA BCAS2 C1S HNRNPA0 HNRNPA3 GPKOW CDC5L PDCD1 DHX9 BST2 TAOK1 SUGP1 PEX19 IGF1R IL6R DNAJB11 PPIE PPIH PPIG CD8B;CD8B2 SUN2 HNRNPU HNRNPR MAP1B WDR61 BTF3 HNRNPL HNRNPK HNRNPD WDR33 GAS6 ISY1;ISY1-RAB43 MED13L PHF5A AUP1 IPO7 PAPOLA TXNL4A SNRPN RAB5B NCL-1 PLRG1 DNAJC8 CEBPD CD33-1 FIP1L1 SEC11A NCK1 SEC11C SNRNP40 DNAJA2 PPIL3 PPIL4 PPIL6 SRRM2 IL1R1 COG1 CRNKL1 LCK CSTF3 CSTF2 CD79B ROCK2 CD79A CHMP1A HNRNPH2 TLR6 EMC4 SPCS3 SPCS2 SPCS1 CWC25 PPIL1-1 CWC27 CWC22 PRPF6 PRPF8 CPSF4 CPSF1 CPSF3 CWC15 FNTB;CHURC1-FNTB CGAS BLNK BTK RBM5 C4BPA C4BPB CLDN1 LOC110384692;C4A;C4B_2;C4B GRPEL1 PQBP1 SRRT CALR-1 KPNA7 KPNA5 KPNA3 SNRNP200 VAV1 CTNNBL1 SIGMAR1 PRCC MERTK KDELR1 CCAR1 TIMD4 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 SYMPK RBM10 PAF1 DYNC1I1 RETREG1 DHX15 DHX16 BCAP31 UBE2I ZBP1 NR3C1 WBP11 HNRNPUL1 RTN3 DDX46 DDX42 SUMO1 RBM17 DYNLT1 BUD31 RBM22 DDX23 CSTF2T RRBP1 PPIA SMNDC1 U2SURP CLP1 TYRO3 MRC1 SF3B4 SF3B5 CSNK2A2 SF3B2 SF3B3 SF3B6 BRD4 DDX3X-1 SF3A3 SF3A1 SF3A2 XAB2 CSNK2B CPSF7 CLEC5A RPL5-1 VTN BAG2 CHERP RCAN3 EIF4G3 EIF4G2 EIF4E3 CX3CR1 CLEC4M;CD209-2 PUF60 SNRPB2 AQR NMI SH3KBP1 PRPF19 MED28-1 PCF11 PACS1 MAPRE3 AXL HDLBP EFTUD2 PDIA3 DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 97%3359478 Defective MUT causes MMAM MMAA MMUT POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.5 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation TDGF1 SALL4 SALL1 DPPA4 STAT3 POU5F1;POU5F1B EPHA1 SOX2 FOXD3 NANOG;NANOGP8 FGF2 ZIC3 DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%69306 DNA Replication CCNA2-1 CCNA1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PSMD12 MGME1 PSMD11 RNASEH1-1 PSMD14 EXOG PSMD13 POLG PRIM2 PRIM1 H2AC20 PSMA7 POLA1 PSMD8 POLA2 H2AB2;H2AB3;H2AB1 PSMB6 DNA2 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 PSMA2-1 ORC1 CDC7 PSMA5 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 CDC6 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 H2AJ TOP3A H2BC5 PCNA UBA52 H2BC1 CUL1 RPA1 RPA2 CDK2 RPA3 RPS27A H2AC4 UBB;UBC KPNA6 MCM10 DBF4 RBX1 POLRMT POLG2 KPNB1 TWNK POLD1 SSBP1 H2BC21 H2AZ2;H2AZ1 RFC5 RFC3 RFC4 RFC2 KPNA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LIG1 POLE RFC1 H2BC15;H2BC3;H2BC11;H2BC12 ANAPC15 ANAPC16 UBE2D1 GINS1 GINS2 ANAPC10 CDC45 ANAPC11 MCM7 MCM8 FZR1 CDC23 POLD3 GINS3 CDC26 GINS4 CDC27 MCM3 POLD4 MCM4 POLD2 ANAPC7 MCM5 MCM6 UBE2C MCM2 POLE4 UBE2E1 FEN1 UBE2S CDC16 CCNE2 ANAPC4 POLE2 CCNE1 ANAPC5 ANAPC1 POLE3 ANAPC2 H2AC14 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling IL11 CBL CNTF LIF SOCS3 STAT1 TYK2 CNTFR PTPN11 IL11RA STAT3 CLCF1 LIFR IL31 OSM IL31RA OSMR IL6 IL6ST CRLF1 JAK1 CTF1 JAK2 IL6R CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-HSA-5660668.2 CLEC7A inflammasome pathway NFKB1 RELA PYCARD MALT1 CASP8 IL1B PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209952 Peptide hormone biosynthesis INHA INHBE FSHB LHB PCSK1 CGA TSHB INHBB INHBA POMC INHBC BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 97%3656248 Defective HEXB causes GM2-gangliosidosis 2 HEXB PROTEIN LOCALIZATION%REACTOME%R-HSA-9609507.4 Protein localization DDO STX1A PHYH-4 IDE SCP2 GSTK1 CROT APP HSCB TOMM20 TOMM22 HSD17B4 CAT TOMM40 TOMM7 SLC25A6 TOMM70 HAO1 ACAA1-1 NUDT7 CS UBE2D3-1 EHHADH-1 IDH3G AGPS ATP5MC1 GRPEL1 VAPA UBA52 CYC1 COX19 VAMP2 ABCD2 COX17 PEX3 RPS27A UBB;UBC CRAT VDAC1 NUDT19 CHCHD4 CHCHD5 TIMM17B PMPCB CMC2 TIMM23 PMPCA TIMM13 CHCHD10-1 TIMM50 PITRM1 GRPEL2 SLC27A2 PAOX TIMM8B DNAJC19 COA4 PECR ATAD1 TIMM8A TIMM44 PEX16 MTX2 PEX10 FIS1 PEX2 HMGCL GFER PEX11B TIMM10B PEX12 SAMM50 GDAP1 PEX13 CHCHD7-1 PEX26 PEX14 CHCHD3 PXMP4 ACOX2 ACOX3 PIPOX MTX1 ACBD5-1 DHRS4 HACL1 ACO2 EMD ACOX1 TYSND1 ABCD1 TIMM17A-1 CHCHD2 ACOT8 ACOT2;ACOT1 ECH1 SEC61G OTC SEC61B TIMM22 TIMM10 LDHD SLC25A17 AGXT FXN PRNP SLC25A12 HSPD1 SLC25A4 STX5 ATP5F1A ATP5F1B ACOT4 SLC25A13 ZFAND6 MPV17 USP9X HMOX1 PEX1 NDUFB8 PEX7 PEX6 GNPAT NOS2 EPHX2 OTOF IDH1 PEX19 HSPA9 UBE2D3;UBE2D2 COQ2 UBE2D1 AMACR LONP2 DAO PXMP2 TIMM21 BCS1L BAAT ABCD3 UBL4A CAMLG SGTA BAG6 GET1 GET3 GET4 TAZ DECR2 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death BCL2L1 REELIN SIGNALLING PATHWAY%REACTOME%R-HSA-8866376.4 Reelin signalling pathway VLDLR FYN RELN SH3KBP1 DAB1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer TGFBR1-1 TGFBR2 SMAD2;SMAD3 TGFB1 THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844615 The AIM2 inflammasome PYCARD AIM2 CASP1 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor DLG3 DLG4 CALM3;CALM1 DLG1 GRIK5 GRIK3 GRIK4 NCALD GRIK1 GRIK2 EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 97%114508 Effects of PIP2 hydrolysis DGKZ DGKQ DGKK DGKI DGKH ABHD6 PRKCE MGLL DAGLA PRKCQ RASGRP2 RASGRP1 DAGLB ITPR1 ITPR2 PRKCD ITPR3 DGKG DGKE DGKD DGKB TRPC7 DGKA TRPC6 ABHD12 PRKCH TRPC3 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037629.2 Lewis blood group biosynthesis ST3GAL4 ST3GAL3 B3GALT4 ST6GALNAC6 B3GALT5 B3GALT2 B3GALT1 FUT2 FUT4 FUT6;FUT5;FUT3 FUT7 B4GALNT2 FUT9 ST3GAL6 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.3 GRB2:SOS provides linkage to MAPK signaling for Integrins FGG SOS1 ITGA2B TLN1 VWF SRC FN1 RAP1A ITGB3 PTK2 FGB FGA RAP1B APBB1IP LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism ELOVL1 ELOVL2 ELOVL3 FADS2 ACSL1 ABCD1 ELOVL5 FADS1 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein PRKCSH MOGS GANAB MGAT1 CANX RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes NCBP1 NABP1-1 INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 CDK7 INTS9 INTS8 INTS11 INTS12 GTF2A1 INTS13 GTF2A2 INTS14 INTS10 ICE1 ICE2 TAF9 SSU72 NABP2 PHAX POLR2A ZNF143 POLR2B ELL2 POLR2C ELL3 ZC3H8 POLR2D RPRD2 RPAP2 RPRD1B SP1 POLR2G RPRD1A SNAPC5 SNAPC1 POLR2I SNAPC2 SNAPC3 SNAPC4 TBP TAF13 TAF11 POU2F1 NCBP2-1 TAF8 POU2F2 TAF6 TAF5 CCNK CCNT1 GTF2B POLR2E POLR2F GTF2F1 POLR2H GTF2F2 POLR2L GTF2E1 GTF2E2 SUPT4H1-1 SRRT SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 PCF11 ELL SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5683826 Surfactant metabolism P2RY2 SLC34A2 SLC34A1 ADRA2C ADRA2A SFTPB SFTPC CTSH CSF2RB TTF1 CSF2RA CKAP4 GATA6 NAPSA ADORA2B CCDC59 ADORA2A PGA4;PGA3;PGA5 ADGRF5 ADA2 LMCD1 ABCA3 ZDHHC2 SFTPD PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 97%6794362 Protein-protein interactions at synapses DLGAP3 IL1RAPL1 DLGAP4 STXBP1 SHANK2 STX1A SHANK1 NLGN3 NLGN1 NLGN2 EPB41 NRXN3 NRXN2 BEGAIN EPB41L5 GRIN2A EPB41L2 PDLIM5 NLGN4X;NLGN4Y HOMER1 HOMER2 LRFN3 SYT7 LRFN2 PTPRF GRIN2B LRFN4 SYT12 GRIN1 LRFN1 APBA3 APBA2 APBA1 GRM1 GRM5 PTPRD PPFIBP2 SLITRK2 SLITRK1 SLITRK4 IL1RAPL2 SLITRK6 RTN3 LRRC4B GRIA1 PPFIBP1 EPB41L1 GRIA3 GRIA4 SHANK3 SLITRK3 DLG1 SLITRK5 SYT9 PTPRS FLOT2 SHARPIN CASK LIN7A LIN7C GRIN2C GRIN2D NTRK3 DLG2 DLG3 DLG4 SYT2 SYT1 NRXN1;NRXN3;NRXN2 PPFIA1 FLOT1 PPFIA4 PPFIA3 PPFIA2 DBNL SYT10 LIN7B SIPA1L1 LRRTM3 LRRTM4 LRRTM1 LRRTM2 DLGAP1 HOMER3 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 97%9764561 Regulation of CDH1 Function MDM2-2 CTNNA1 CDH1 JUP PSMD12 VCL PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 SRC PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 BANP ADRM1 CTSS PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CTNND1 PSMC6 MTBP PSMA4 RACK1 CBLL1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 CTSB CTSV;CTSL UBA52 DNM2 RPS27A UBB;UBC RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME DATABASE ID RELEASE 97%9820952 Respiratory Syncytial Virus Infection Pathway MED13L TLR2 MED1 RAB5B CSNK2A1;CSNK2A3 MED4 MED6 NCL-1 PPP1CC MED7 CCNC-1 SDC4 SEC11A SEC11C SDC2 CREBBP SDC3 TLR6 SDC1 MED16 MED17 SPCS3 MED12 SPCS2 RAB5A MED14 SPCS1 MED13 EGFR MED10 JAK1 PPP1CB MED19 MED15 MED18 MED11 TYK2 MED27 PPP1CA MED23 HSP90AA1 DDX58 MED26 MED24 ISG15 MED29 TLR7 UBE2L6 HERC5 MED22 MED20 IFIH1 MED25 TRIM25 GPC1 ARIH1 MED21 GPC3 GPC2 XPO1 GPC5 UBA52 GPC4 GPC6 STAT2 MED31-1 AGRN EP300 RPS27A UBB;UBC HSPA8 MED30 RBX1 IFNAR1 CDK8 BCAP31 KPNB1 MAVS HSPG2 HSP90AB1 IRF3 BECN1 MED8 MED9 CUL5 IFNB1-4 CSNK2A2 TLR3 LY96 CSNK2B CDK19 CD14 TLR4 H2BC15;H2BC3;H2BC11;H2BC12 IGF1R CX3CR1 CLEC4M;CD209-2 FURIN RAB5C MED28-1 MAP1B EIF2AK2 ELOC-1 ELOB DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 97%3595174 Defective CHST14 causes EDS, musculocontractural type BCAN VCAN DCN CSPG5 NCAN CHST14 BGN REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion ABCC8 STXBP1 STX1A GNA14 GNG10 GNAS-1 GNA15 GNG2 GNG5 GNG4 PRKAR1B GNA11 PRKAR1A GNG8 CHRM3 INS;INS-IGF2 ADCY8 ADCY6 ADCY5 GNG13 CACNB2 PRKACB-1 CACNB3 GNAQ CACNA2D2 GNB2 PRKAR2A GNB1 GNB4 GNB3 ITPR1 ITPR2 GNB5 ITPR3 FFAR1 SNAP25 IQGAP1 GNAI1 GNAI2 CD36 KCNC2 GCG PRKACA-1 AKAP5 KCNS3 ADRA2C ADRA2A KCNJ11 MARCKS GNGT1 RAPGEF3 PRKCA VAMP2 RAPGEF4 PRKAR2B CACNA1A PLCB3 CACNA1D GLP1R SLC2A1 SLC2A2 CACNA1C KCNB1 PLCB1 CACNA1E AHCYL1 PLCB2 KCNG2 RAP1A SYT5 ACSL4 ACSL3 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 97%9627069 Regulation of the apoptosome activity APAF1 UACA AVEN DIABLO-1 CASP9 MAPK1 MAPK3 CYCS-1 APIP XIAP TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 97%167243 Tat-mediated HIV elongation arrest and recovery CCNT1 SUPT16H POLR2E POLR2F CTDP1 POLR2H GTF2F1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I SUPT4H1-1 SUPT5H CDK9 SSRP1 POLR2J;POLR2J2;POLR2J3 TCEA1 ELL ELOC-1 ELOA NELFB ELOB NELFCD NELFA NELFE TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%379724 tRNA Aminoacylation MARS1 AIMP1 SARS1 AIMP2 EPRS1 RARS1 QARS1 IARS1 LARS1 KARS1 EEF1E1 PPA2 RARS2 AARS2 PARS2 MARS2 DARS2 AARS1 HARS2 YARS2 HARS1 YARS1 FARS2 WARS1 WARS2 LARS2 GARS1 NARS1 DARS1 SARS2 NARS2 FARSA TARS2 CARS1 PPA1-1 IARS2 TARS1 VARS2 FARSB VARS1 CARS2 EARS2 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome ABCC9 KCNJ11 INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling TRIM62 TRIM22;TRIM34;TRIM6-TRIM34 IFNGR1 TRIM46 IFNGR2 TRIM45 GBP2;GBP3;GBP1 TRIM35 TRIM38 TRIM31 B2M TRIM29 TRIM26 TRIM14 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E TRIM10 MID1 JAK2 IRF4 VCAM1 SOCS1 IRF6 IRF9 PIAS1 IRF8 HLA-DPB1-1 HLA-DQB2;HLA-DQB1 SUMO1 HLA-DPA1 IRF1 IRF2 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 IRF3 HLA-DRA TRIM8 TRIM6 GBP7;GBP4 TRIM5 TRIM2 IRF7 TRIM3 SMAD7 JAK1 YBX1 FCGR1A CAMK2B CAMK2D CAMK2A NCAM1 CAMK2G PML PTPN11 PTPN6 SP100 RAF1 TRIM25 GBP6 CD44 SOCS3 PRKCD PTAFR PTPN1 OASL TRIM21 IFNG OAS1 OAS3 IRF5 MAPK1 MAPK3 GBP5-1 MT2A CIITA IFI30 TRIM68 ICAM1 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.3 ATF6B (ATF6-beta) activates chaperones MBTPS2 ATF6B HSPA5 MBTPS1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 97%948021 Transport to the Golgi and subsequent modification COG4 COG3 COG2 SPTBN2 BET1L ANK2 TGFA GOLGB1 SPTBN4 B4GALT6 SPTBN5 CTSC B4GALT4 B4GALT5 TRAPPC3 TRAPPC1 GOSR2 CAPZA3 ST6GAL1 ACTR10 TRAPPC4 TRAPPC5 SAR1B TRAPPC9 ST3GAL4 ARFGAP3 GOLGA2 COG1 ARFGAP2 DCTN6 DCTN5 DCTN4 ARF4-1 SPTA1 TRAPPC2;TRAPPC2B GRIA1 B4GALT1 TRAPPC6A NSF TMED2-1 TRAPPC6B ANK3 RAB1A RAB1B TRAPPC10 ACTR1A AREG ARF1 CSNK1D SCFD1 SPTBN1 MGAT5 GBF1 MGAT1 COL7A1 DYNC1I2 MGAT2 DCTN2 DCTN3 SEC24D-1 COPB1 MAN2A2 MGAT3 ST8SIA6 SPTAN1 CHST8 ST8SIA2 FUCA1 ST8SIA3 CD59 CD55 DYNC1H1 DYNC1LI1 KDELR1 DYNC1LI2 LHB ANK1 FUT8 MAN2A1 SEC31A DYNC1I1 MIA2 MIA3 INS;INS-IGF2 CAPZB MAN1A2 MAN1C1 TMEM115 MAN1A1 CTSZ MGAT4A-1 CHST10 DCTN1 MANEA SEC22B SEC23A CAPZA1 LMAN1 CAPZA2 SEC24B STX5 SEC24A YKT6 MGAT4C KDELR2 MGAT4B COPB2 COPA SEC24C CGA COPE MCFD2 SERPINA1 PPP6C TMED3 PPP6R1 TMED7 PPP6R3 LMAN1L TMED9 COPZ2 GORASP1 COPZ1 SEC22A SEC22C NAPB TMED10 ARF5 STX17 LMAN2L USO1 FUT6;FUT5;FUT3 NAPG LMAN2 SEC31B ANKRD28 SEC23IP CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 ARCN1 COPG2 FOLR1 CNIH3 COPG1 BET1 F5 F8 B4GALT2 B4GALT3 NAPA TFG SPTB GOSR1 ARFGAP1 TRAPPC2L COG8 TBC1D20 COG7 PREB COG6 KDELR3 COG5 SEC13 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events CAMK2G ADCY9 PRKAR1B PRKAR1A ADCY4 ADCY3 CALM3;CALM1 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKCG PRKCD NBEA PRKCA CAMK4 PDE1C PRKAR2B CAMKK1 GRK2 CAMKK2 KPNA2 PRKX CAMK2B CAMK2D PDE1B PDE1A CAMK2A PRKACA-1 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717323 ceritinib-resistant ALK mutants ALK LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9615710 Late endosomal microautophagy VPS37C VPS37D VPS37A VPS37B IFT88 CHMP3 CHMP6 CHMP7 CFTR CHMP4C CHMP4B PLIN2 CHMP4A VPS28 TSG101 MVB12B MVB12A UBA52 HDAC6 CETN1 PLIN3 CHMP2B HBD;HBB RNASE1 RPS27A PCNT CHMP2A UBAP1 ARL13B UBB;UBC HSPA8 PARK7 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases ARSG STS ARSD-1 ARSA ARSL ARSB ARSJ ARSK ARSH SUMF2 ARSI SUMF1 CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%6798163 Choline catabolism SLC44A1 SLC44A2 BHMT DMGDH ALDH7A1 SARDH SLC22A4 CHDH DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 97%5654696 Downstream signaling of activated FGFR2 FRS2 FGF20 GAB1 SOS1 PIK3CA FGF23 PTPN11 FGF2 FGF7 FGF22 FGF3 FGF10 PLCG1 HRAS PIK3R1 FGF1 FGF6 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.2 Regorafenib-resistant PDGFR mutants PDGFRA DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932504 DAG1 core M2 glycosylations MGAT5B-1 POMT2 DAG1 POMT1 POMGNT1 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling TGFBR3 GIPC1 FGF2 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters SLC34A2 SLC20A1 SLC34A1 SLC20A2 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen GP1BA GP5 GP9 VWF GP1BB ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation UBE2V1 MAPKAPK2 MAP2K6 IRAK1 IRAK2 TRAF6 MAP3K7 MAP2K3 MAPK14 MAPK11 IKBKG NOD1 MAPKAPK3 NOD2 UBE2N TAB3 RIPK2 TAB2 TAB1 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 97%9012852 Signaling by NOTCH3 HES1 SNW1 MAMLD1 MIB2 FABP7 WWC1 WWP2 PBX1 KAT2B DLGAP5 PTCRA KAT2A DLL4 HES5 PSENEN NEURL1 TACC3 MIB1 HEY1 HEY2 CREBBP JAG1 UBA52 ADAM10 NOTCH1 STAT1 PLXND1 RBPJ DLL1 JAG2 PSEN1 HEYL MAML2 EP300 MAML1 RPS27A NCSTN PSEN2 UBB;UBC NEURL1B EGF APH1A EGFR APH1B MAML3 NOTCH3 YBX1 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 DDIT3 RPS11 RPL10A GCN1 RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 ATF2 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 ASNS RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 CEBPG RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 EIF2S2 EIF2S3;EIF2S3B RPLP2 EIF2S1 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 CEBPB EIF2AK4 ATF4 RPL18A RPL23A FAU ATF3 TRIB3 RPL12-1 RPS27A RPS9 RPS7 RPS8 IMPACT RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 97%180024 DARPP-32 events PPP2R1A PDE4A PPP1CA PPP3R1 PDE4C PPP2CB;PPP2CA PRKAR2B PRKAR1B PRKAR1A PPP2R5D CDK5 PPP1R1B PPP2R1B PPP3CC PDE4D-1 CALM3;CALM1 PPP3CA PPP3CB PRKACB-1 PRKAR2A PRKACA-1 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 GAB1 MET PTPN11 HGF MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 97%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes HSPG2 GJA1 ITGB1 PANX1 ITGA5 SPP1 P2RX7 CACNA1H ITGAV ITGB3 CACNG7 CACNB2 CACNB3 CACNB1 PIEZO1 CACNA2D1 AKT1 MTOR SIGNALLING%REACTOME%R-HSA-165159.10 MTOR signalling AKT2 SLC38A9 AKT3 STK11 PGK1 PRKAB2 AKT1S1 RHEB EIF4EBP1 PRKAB1 RRAGA CAB39 RRAGC RRAGB MLST8 RRAGD FKBP1A EEF2K PRKAA1 CAB39L STRADA PRKAG2 STRADB MTOR TNRC6C MOV10 TNRC6A-1 PRKAA2 AGO4 AGO2 PRKAG1 AGO3;AGO1 TNRC6B PRKAG3 EIF4E RPTOR EIF4B YWHAB AKT1 TSC2 TSC1 PPM1A LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RPS6 EIF4G1 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde KPNA2 CAMK2G CALM3;CALM1 CAMK4 CAMKK1 CAMK2B CAMKK2 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis AZIN2 AGMAT GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling SOS1 EREG BTC EGF AREG TGFA HRAS EGFR HBEGF EPGN NRAS DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 CYP21A2 FERTILIZATION%REACTOME DATABASE ID RELEASE 97%1187000 Fertilization HVCN1 ADAM2 ZP3;POMZP3 ACR IZUMO1-1 OVGP1 IZUMO3 IZUMO2 IZUMO4 ZP1 ZP2 CATSPER1 ZP4 ADAM21 KCNU1 CATSPER3 ADAM20 ADAM30 CATSPERB CATSPER2 B4GALT1 CATSPERD CATSPER4 CD9 CATSPERG SPAM1 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 97%5609978 Defective GALT can cause GALCT GALT SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 97%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) GGT5 ALOX5AP MAPKAPK2 CYP4F22 ALOX15 GGT1 LTA4H DPEP2 CYP4B1 DPEP1 LTC4S ALOX5 PTGR1-1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 ABCC1 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis PSMA6 PSMC5 FBXL7 PSMA3 PSMC6 PSMA4 RBX1 PSMC3 FBXL18 PSMA1 PSMC4 PSMC1 SKP1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 AURKA PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex ACTL6A BCL7C SMARCA2 BCL7B BRD7 SMARCA4 SMARCC1 SMARCC2 ACTB-1 SMARCE1 SMARCD1 SMARCB1 SMARCD2 PHF10 ARID2 BCL7A SMARCD3 PBRM1 THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome NLRP1 BCL2 BCL2L1 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 97%5579015 Defective CYP26B1 causes RHFCA CYP26B1 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 97%9924644 Developmental Lineages of the Mammary Gland EGF FGF10 AREG TGFA PRL MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 97%429958 mRNA decay by 3' to 5' exoribonuclease DIS3 SKIV2L EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 WDR61 HBS1L TTC37 NT5C3B DCPS ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins CDK1 BUB1B CDC20 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CCNB1 ANAPC11 PTTG1;PTTG2 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PLK1 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%169893 Prolonged ERK activation events FRS2 NGF KIDINS220 MAP2K2;MAP2K1 RAP1A RAPGEF1 MAPK1 YWHAB BRAF CRK MAPK3 CRKL NTRK1 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%1614635 Sulfur amino acid metabolism FMO1 BHMT ENOPH1 TXN2 TST MAT1A ADI1 MPST GOT1-1 BHMT2 CDO1 TSTD1 ADO ETHE1 CTH CSAD SUOX MRI1 MTR-1 GOT2-1 MTRR AHCY CBS;CBSL APIP MTAP GADL1 SQOR SLC25A10 RHOT2 GTPASE CYCLE%REACTOME%R-HSA-9013419.2 RHOT2 GTPase cycle MFN1 MYO19 MFN2 TRAK1 TRAK2 RAP1GDS1 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense CALM3;CALM1 UBB;UBC GBP6 GBP2;GBP3;GBP1 UBE2D3;UBE2D2 CASP5;CASP4 RPS27A UBA52 GBP7;GBP4 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition AKT2 AKT3 FBXO5 CCNA2-1 CCNA1 PSMD12 PSMD11 PSMD14 CDC25A PSMD13 PRIM2 PRIM1 PSMA7 POLA1 PSMD8 POLA2 PSMB6 PSMB7 PSMD6 E2F4-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 TFDP1 PSMD3 TFDP2 PSMB1 PSMD1 ADRM1 GMNN ORC5 PSMC2-1 ORC4 ORC6 E2F1 PSMA2-1 ORC1 CDC7 PSMA5 ORC3 SEM1 ORC2 PSMA6 CDT1 PSMC5 PPP2R1A CDC6 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 SKP1 PCNA AKT1 UBA52 CUL1 RPA1 PTK6 RPA2 CCNB1 CDK4 CDK2 PPP2CB;PPP2CA RPA3 RPS27A PPP2R1B UBB;UBC MCM10 DBF4 CDK1 CDK7 MNAT1 DHFR2;DHFR CKS1B PPP2R3B TYMS RBL2 CABLES1 RBL1 WEE1 MYC HDAC1 RBBP4 MAX CCND1 POLE LIN54 LIN37 LIN9 LIN52 TK1 CDC45 MCM7 MCM8 MCM3 MCM4 MCM5 E2F5 MCM6 E2F6 MCM2 POLE4 RRM2-1 CCNE2 POLE2 CCNE1 RB1 POLE3 CCNH ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%R-HSA-2426168.6 Activation of gene expression by SREBF (SREBP) MVD HELZ2 GGPS1 MVK MED1 IDI1 HMGCS1-1 FDFT1 TM7SF2 SQLE ACACB ACACA CYP51A1 ELOVL6 TGS1 CREBBP SP1 SCD PMVK FDPS RXRA SREBF2 GPAM CARM1 MTF1 CHD9 PPARA NFYA-1 DHCR7 TBL1XR1 NFYB FASN SC5D LSS NFYC NCOA1 NCOA2 NCOA6 SMARCD3 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358749 CTNNB1 S37 mutants aren't phosphorylated PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription RB1 DDX5 ZCRB1 VHL MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination MTERF1-1 VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964046 VLDL clearance APOBR APOC1 VLDLR APOC4 APOB LSR MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase CDK1 NUP133 NUP50 POM121;POM121C NUP54 NUMA1 RAB2A GORASP2 BLZF1 SMC4 SMC2 NUP42 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NUP43 H2BC21 GOLGA2 RAE1 RANBP2 ARPP19 EMD NCAPH2 NCAPG2 H2AC20 ENSA H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 NCAPD3 MASTL MCPH1 LPIN1 LPIN2 NUP35 LPIN3 RAB1A RAB1B NUP37 PPP2R1A NUP107 NUP188 BANF1 LEMD3 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP210 GORASP1 NUP93 LMNB1 NUP205 USO1 NEK9 NEK6 H2BC15;H2BC3;H2BC11;H2BC12 AAAS NEK7 H2BC5 PPP2R2A;PPP2R2D NUP160 NUP85 H2BC1 NUP214 TPR NUP88 PRKCA NUP155 CCNB2 CCNB1 NUP153 PPP2CB;PPP2CA SET-1 PPP2R1B H2AC4 NUP62 MAPK1 RB1 KMT5A VRK1 LEMD2 PLK1 CTDNEP1 CNEP1R1 PRKCB NDC1 H2AC14 SEC13 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes CDK1 NPM1-2 CCNA2-1 CCNA1 CNOT10 CNOT4 CNOT6 RGCC CNOT7 CNOT11 PLK2 CNOT1 CNOT2 CNOT3 CNOT8 CNOT9 SFN CARM1 ZNF385A E2F4-1 TP53 TFDP1 PCBP4 RBL2 TFDP2 RBL1 PLK3 PRMT1 E2F1 GADD45A E2F7 E2F8 ARID3A BAX CDKN1A BTG2 CDKN1B TNKS1BP1 CNOT6L PCNA PLAGL1 AURKA CCNB1 CDK2 EP300 CCNE2 CCNE1 CENPJ CDC25C CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex ORC2 CDC6 MCM8 ORC5 ORC4 ORC6 ORC1 ORC3 CREB PHOSPHORYLATION%REACTOME%R-HSA-199920.3 CREB phosphorylation RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPKAPK2 ATF1 CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 97%9707564 Cytoprotection by HMOX1 BLVRB BLVRA HELZ2 STAT3 MED1 NLRP3 COX7B COX7C TGS1 CREBBP SIN3A COX8A COX8C RXRA CARM1 PPARA COX4I1 HBD;HBB COX4I2 TXNIP COX5B COX5A HBA2;HBA1 ALB NCOA1 NCOA2 COX7A2L-1 NCOA6 SMARCD3 HDAC3 COX6C MAFK NFE2L2 HMOX1 NCOR2 HMOX2 COX6A1 COX6A2 NCOR1 COX7A2 COX6B2 COX6B1 STAP2 PTK6 NDUFA4 CHD9 CYCS-1 BACH1 TBL1XR1 HM13 FABP1 ABCC1 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013425 RHOT1 GTPase cycle MYO19 RHOT1 TRAK1 TRAK2 RAP1GDS1 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 97%8941284 RUNX2 regulates chondrocyte maturation HDAC4 IHH GLI2 CBFB REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9759475.2 Regulation of CDH11 Expression and Function CTNND1 TNRC6C MOV10 TNRC6A-1 AGO4 SNAI1 AGO2 CDH11 CTNNB1 AGO3;AGO1 TNRC6B ADAM33 CTNNA1 CDH8 JUP ADAM19 ANGPTL4 CDH24 SP1 PRDM8 HEYL ILF3 FOXF1 BHLHE22 HOXC8 ZEB2 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 97%5633007 Regulation of TP53 Activity AKT2 AKT3 CSNK2A1;CSNK2A3 CCNA2-1 CCNA1 TAF9 PRKAB2 TP53RK NOC2L SGK1-1 KAT5 TAF9B CHEK2 CHEK1 TP63 DAXX HUS1 TAF15 PRKAB1 TAF12 TAF13 TAF10 TAF11 SSRP1 DNA2 RHNO1 PHF20 TAF8 L3MBTL1 TAF7 MEAF6 MAPKAP1 TAF6 NUAK1 TAF5 TAF4 TAF3 TP53BP2 ATRIP TAF2 TAF1 BANP BARD1 PLK3 PRKAG2 TPX2 RAD17 ATM PPP2R1A ATR TP73 SETD9 PRKAG1 BRCA1 PRKAG3 ING5 ING2 PRMT5 BRD1 RMI2 RMI1 TOP3A MBD3 BRPF3-1 AKT1 UBA52 WRN RICTOR BRD7 GATAD2B AURKA RPA1 GATAD2A RPA2 CDK2 HIPK1 PPP2CB;PPP2CA POU4F1 POU4F2 HIPK2 TTC5 EP300 RPA3 PPP2R5C RPS27A CCNG1 RAD1 PPP2R1B UBB;UBC MRE11 MAPK14 MAPK11 KMT5A NBN USP7 USP2 CDK1 KAT6A MAPKAPK5 SMYD2-1 BLM MDM2-2 MAP2K6 STK11 CDK5 BRPF1 CHD4 CHD3 JMY PIN1 MDM4 RAD9B RAD9A PRR5 DYRK2 PPP1R13B EXO1 PIP4K2A TBP PDPK1 PPP1R13L PIP4K2B MLST8 PIP4K2C TOPBP1 ZNF385A RFC5 RFC3 RFC4 TP53 RFC2 PRDM1 PRKAA1 RNF34 AURKB TP53INP1 HDAC2 RBBP8 RFFL HDAC1 PML MTOR RAD50 CSNK2A2 PRKAA2 RBBP4 SUPT16H CSNK2B RBBP7 MTA2 PIP4P1 CDK5R1 CDKN2A TAF4B BRIP1 TAF7L EHMT2 EHMT1 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion KCNS3 GNG10 GNAS-1 GNG2 GNG5 GNG4 PRKAR1B GNG8 PRKAR1A ADCY8 ADCY6 ADCY5 GNG13 PRKACB-1 GNB2 PRKAR2A GNB1 GNB4 GNB3 ITPR1 GNGT1 ITPR2 RAPGEF3 GNB5 ITPR3 RAPGEF4 PRKAR2B GLP1R KCNB1 IQGAP1 KCNG2 RAP1A KCNC2 GCG AKAP5 PRKACA-1 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination PRKDC TMEM129 HLTF RNF152 SHPRH CTR9 PEX10 PEX2 RTF1 PEX12 PEX13 PEX14 RNF40 RNF144A UBE2G1 SELENOS UBE2G2 PAF1 WAC-1 RNF181 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E RAD18 DERL1 USP5 UBE2N UBE2Z RRAGA UBE2E3 UBE2T UBE2V2 RNF20 UBA6 UBE2D3-1 USP9X UBE2H UBE2B CDC73 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LEO1 CDC34 UBE2W UCHL3 BCL10 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 PCNA UBE2D3;UBE2D2 UBA1 UBA52 UBE2K H2BC1 UBE2Q2 UBE2D1 UBE2R2 VCP-1 RPS27A UBE2C UBE2E1 UBB;UBC UBE2J2 UBE2S WDR61 USP7 OTULIN RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 97%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 CSF2 CREBBP PRKCB LGALS3 CBFB DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9693928 Defective RIPK1-mediated regulated necrosis RIPK3 FADD MLKL TRADD TRAF2 CASP8 RIPK1 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME DATABASE ID RELEASE 97%9925563 Developmental Lineage of Pancreatic Ductal Cells LAMA5 LAMA3 LAMA2 LAMA4 FN1 LAMB3 LAMB2 LAMB1 VTN LAMA1 LAMC3 LAMC2 LAMC1 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 97%72306 tRNA processing NUP133 NUP50 URM1 WDR4 POM121;POM121C THADA EPRS1 NUP54 LAGE3 OSGEP THG1L ALKBH8 TRMT44 C9orf64 TRDMT1 PUS3 TRMT10A METTL1 NSUN2 TPRKB ADAT1 NUP42 TRMT1 NSUN6 CDKAL1 PUS7 FTSJ1 TP53RK ADAT3 NUP43 TRIT1 ADAT2 QTRT1 TRMT9B DUS2 RAE1 QTRT2 RANBP2 CTU2 CTU1 TRMT6 CSTF2 TRMT13 TRMT11 TRMT61A NUP35 RAN NUP37 CPSF4 CPSF1 TRMT112 NUP214 TYW5 TYW1;TYW1B TRMT5 TYW3 TRMT12 LCMT2 POP5 POP7 POP1 TSEN15 POP4 RPP30 RTCB ZBTB8OS TSEN2 TSEN54 RPP38 RPP21 RPP25 TSEN34 DDX1 RPP14 C2orf49 CLP1 RTRAF RPP40 XPOT FAM98B YRDC NUP107 TRMU OSGEPL1 NUP188 MTO1 TRMT61B GTPBP3 NUP210 NUP93 TRMT10C PRORP TRNT1 NUP205 HSD17B10 AAAS NUP160 NUP85 TPR NUP88 NUP155 NUP153 NUP62 NDC1 SEC13 HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly ABCA1 A2M PRKACB-1 APOA1 ZDHHC8 PRKACA-1 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956553 OTC main chain variants cause OTC deficiency OTC IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants KIT CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 97%71262 Carnitine synthesis ALDH9A1 SHMT1 TMLHE BBOX1 NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 97%9735786 Nucleotide catabolism defects PNP-1 IFIT ANTIVIRAL RESPONSE%REACTOME%R-HSA-9684482.1 IFIT antiviral response RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F RPS4X EIF3D EIF3A EIF3B RPS3A RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 IFIT1 IFIT3 IFIT2 SKP1 RPS27L RPS15A RPS3 IFIT5 RPS2 CUL1 FAU RPS27A RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 FGFR3 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling FGF20 FGF23 INSR TGFA PIK3R3 PIK3R6 PIK3R5 IRS2 LCK SRC PIP5K1A PIP5K1B PIP5K1C EGF ERBB2 EGFR PDGFRA FGF6 HGF GAB1 PPP2R1A MET AREG RAC1 NRG1 NRG2 FGF7 EREG BTC FGF22 FGF3 FGF10 NRG3 NRG4 HBEGF KIT NTRK3 AKT1 NTF3 PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG PPP2R5E VAV1 IER3 FLT3LG PDGFB CD19 CD28 STRN GAB2 IL33 CD86 FGF2 IRAK1 KLB CD80 PDGFRB INS;INS-IGF2 FGF19 FGFR4 IL1RL1 TRAT1 FLT3 PIK3AP1 ESR1 PIP4K2A PIP4K2B PIP4K2C PIK3CD TRAF6 PIK3CG IRS1 PIK3R2 ESR2 PIK3CB PIK3R1 FYN FRS2 PIK3CA MYD88 PTPN11 IRAK4 EPGN NTRK2 BDNF MAPK1 MAPK3 FGF1 FGF4 FGF16 FGF9 FGF18 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes ATM BAX TP73 NDRG1 PMAIP1 CHM BID BCL2L14 BBC3 ZNF420 FAS AIFM2 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CASP10 TP53I3 BCL6 CREBBP PERP TP63 PPP1R13B NLRC4 PIDD1 CASP6 CASP2 CASP1 APAF1 TP53 RABGGTB RABGGTA STEAP3 TP53BP2 BIRC5 PRELID3A TMEM219 BNIP3L TP53INP1 PRELID1 CRADD IGFBP3 THREONINE CATABOLISM%REACTOME%R-HSA-8849175.6 Threonine catabolism SDSL SDS RIDA DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 97%3560782 Diseases associated with glycosaminoglycan metabolism VCAN EXT1 EXT2 CSPG5 FMOD CHST6 LUM CHSY1-1 CHST14 B4GALT7 PRELP DCN GPC1 SDC4 GPC3 KERA B3GAT3 SDC2 GPC2 SDC3 GPC5 GPC4 SLC26A2 OGN HSPG2 GPC6 BCAN ST3GAL3 CHST3 OMD B3GALT6 ACAN B4GALT1 AGRN SDC1 PAPSS2 HEXB NCAN HEXA BGN CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 97%9793528 Ciprofloxacin ADME ALB ABCG2 SLCO1A2 SLC22A1 SLC22A8 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%5619115 Disorders of transmembrane transporters ABCG5 ABCC8 NUP133 SLC34A2 SLC34A1 SLC6A19 SLC39A4 NUP50 SLC36A2 POM121;POM121C SLCO2A1 SLC6A14 ABCC6 NUP54 ABCC9 SLC26A4 SLC7A7 SLC26A3 AVPR2 SLC7A9 NUP42 NUP43 SLC26A2 PSMD12 PSMD11 PSMD14 RAE1 PSMD13 RANBP2 PSMA7 SLC35A2 PSMD8 SLC35A3 SLC33A1 SLC35C1 SLC22A12 PSMB6 SLC22A18 PSMB7 PSMD6 ABCB4 PSMB4 PSMD7 PSMB5 PSMB2 NUP35 PSMB3 PSMD2 PSMD3 SLC29A3 SLC27A4 PSMB1 PSMD1 SLC17A8 SLC5A5 ADRM1 NUP37 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 ABCA1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 SLC24A5 PSMA1 SLC40A1 PSMC4 PSMC1 HEPH APOA1 CFTR KCNJ11 SLC5A7 ABCB6 SLC5A2 ABCA3 UBA52 NUP214 ERLIN1 ERLIN2 SLC9A6 CP SLC9A9 SLC16A1 ABCB11 VCP-1 RPS27A DERL2 RNF5 UBB;UBC OS9 RNF185 LMBRD1 SLC22A5 SLC12A3 SLC12A1 SLC12A6 DERL3 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 DERL1 SLC3A2 BSG SLC5A1-1 SLC35A1 ABCD1 ERLEC1 ABCA12 SLC2A9 SLC6A5 SLC6A2 SLC6A3 SLC2A10 NUP107 NUP188 NUP210 RHAG NUP93 NUP205 AAAS NUP160 NUP85 SLC24A1 TPR SLC24A4 NUP88 GCKR NUP155 GCK SLC11A2 NUP153 ABCD4 SLC2A1 SLC2A2 SLC4A1 SLC4A4 AVPR1B HK1 SLC1A1 AVPR1A SLC1A3 NUP62 SLC17A5 AVP SLC3A1 SLC20A2 SLC6A20 NDC1 ABCG8 SEC13 ABCC2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 97%76005 Response to elevated platelet cytosolic Ca2+ TTN-1 STXBP3 STX4 CAP1 VEGFA CD109 RAB27B PRKCG APP TLN1 ISLR HABP4 CHID1 PSAP GTPBP2 SYTL4 TAGLN2 NHLRC2 TEX264 SERPINE1 LY6G6F;LY6G6F-LY6G6D ALB EGF ENDOD1 APOH PECAM1 SPARC VTI1B MANF CALU CD36 MAGED2 FERMT3 ECM1 OLA1 PCDH7 CTSW TIMP3 HGF ANXA5 TOR4A SPP2 VEGFB VEGFC VEGFD AHSG LHFPL2 PCYOX1L FAM3C ACTN1 LEFTY2;LEFTY1 APLP2 TMX3 APOA1 SELENOP SCG3 PFN1 HSPA5 RARRES2 CYRIB SCCPDH LAMP2 LGALS3BP WDR1 PLEK PHACTR2 SRGN ITIH4 ITIH3 CLEC3B CDC37L1 TUBA4A BRPF3-1 STXBP2 PPBP PRKCA ITGA2B VWF ABCC4 PF4;PF4V1-1 TGFB2 TGFB3 MMRN1 PRKCB CYB5R1 TF PDGFB APOOL SELP ORM2;ORM1 QSOX1 CD63 ACTN4 VCL IGF2 A1BG FN1 IGF1 SERPINA3 PPIA A2M SERPINF2 ALDOA HRG THBS1 FLNA CFD TIMP1 SERPINA1 TGFB1 CALM3;CALM1 ACTN2 ITGB3 PROS1 F13A1 CFL1 FGB FGA FGG F5 PLG F8 SOD1 SERPING1 CLU KNG1 CD9 GAS6 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME%R-HSA-9656255.2 Defective OGG1 Substrate Binding OGG1 DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%73887 Death Receptor Signaling SOS1 GNA13 TBK1 ULK1 RASGRF2 TNF PLEKHG2 TAX1BP1 SOS2 PRKCI PRDM4 YWHAE IKBKE NGFR RIPK2 RNF31 XIAP OTUD7B SPATA2 TNFAIP3 SMPD3 SHARPIN USP21 USP4 SMPD2 RACK1 MIB2 UBE2D3-1 TNFRSF1A CYLD PLEKHG5 RBCK1 OTUD1 BIRC2 RAC1 CHUK BIRC3 OPTN-1 RHOA CASP10 KALRN IKBKB CFLAR IKBKG NET1 UBA52 NGF AKAP13 MAPKAPK2 VAV3 RPS27A TRIO PSEN2 UBB;UBC ITSN1 MAP3K7 APH1A VAV1 APH1B VAV2 TIAM2 SPPL2B SPPL2A PREX1 CLIP3 ARHGEF3 NSMAF ARHGEF4 MAPK8 ARHGEF1 OTULIN USP2 ARHGEF2 ARHGEF7 ARHGEF5 BCL2L11 ARHGEF6 BAD NGEF IRAK1 PSENEN ABR LINGO1 MAG OMG RTN4 SQSTM1 TAB3 TAB2 TAB1 ADAM17 ARHGEF33 ARHGEF37 ARHGEF38 PSEN1 CASP2 NCSTN TRAF6 ARHGDIA ARHGEF40 FGD1 FGD2 FGD3 FGD4 HDAC2 ARHGEF26 BEX3 HDAC3 HDAC1 MYD88 CASP3 TRADD FASLG MCF2 TRAF2 CASP8 TNFSF10 ECT2 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A ARHGEF39 FADD BAG4 UBE2D3;UBE2D2 NFKBIA TRAF1 TIAM1 ARHGEF10L UBE2D1 RELA MCF2L ARHGEF11 AATF ARHGEF10 MAGED1 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF16 ARHGEF19 NFKB1 ARHGEF18 ITGB3BP STUB1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%113510 E2F mediated regulation of DNA replication ORC2 CDK1 PPP2R1A PRIM2 PRIM1 CCNB1 POLA1 MCM8 PPP2CB;PPP2CA POLA2 PPP2R1B TFDP1 TFDP2 RB1 ORC5 PPP2R3B ORC4 ORC6 E2F1 ORC1 ORC3 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%1989781 PPARA activates gene expression NR1H4 G0S2 MED13L NR1H3 FAM120B AGT MED1 ACSL1 MED4 MED6 AHR MED7 PEX11A CCNC-1 PPARGC1A PPARGC1B CREBBP RGL1 SREBF2 CLOCK ABCB4 ACADM ESRRA MED16 MED17 NFYA-1 MED12 MED14 MED13 MED10 CD36 RXRB NCOA1 NCOA2 MED19 NCOA6 MED15 NCOA3 ABCA1 MED18 HMGCS2 MED11 MED27 MED23 APOA2 NCOR2 APOA1 APOA5 NCOR1 MED26 MED24 TXNRD1 MED29 MED22 MED20 MED25 PLIN2 ANGPTL4 MED21 GPS2 MED31-1 CHD9 EP300 CPT2 CPT1A SLC27A1 TBL1XR1 TIAM2 FABP1 FADS1 MED30 HELZ2 CDK8 HMGCS1-1 NRF1 NPAS2 SULT2A1-4 TGS1 NR1H2 RORA GLIPR1 SP1 ANKRD1 RXRA CYP7A1 ALAS1 CARM1 PPARG PPARA FHL2 ME1 MED8 NFYB MED9 ARNT NFYC GRHL1 SMARCD3 HDAC3 ARNTL TNFRSF21 ARNT2 FDFT1 NR1D1 CDK19 CYP1A1 MTF1 AHRR TRIB3 MED28-1 THRAP3 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 97%444209 Free fatty acid receptors FFAR4 FFAR1 FFAR2 FFAR3;GPR42 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 BRCA2 RAD51AP1 DNA2 XRCC2 PALB2 BRIP1 MRE11 NBN BARD1 RBBP8 SEM1 RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle FLOT2 FRS2 WDR6 FAM83B ANKRD26;CCDC144A;LOC105375816 DSP DST PLEKHG5 KIDINS220 TXNL1 ARHGAP35 LEMD3 TMEM59 GRB7 VANGL1 CCDC88A PTPN13 DEPDC1B VANGL2 UBXN11 CPD DLG5 CAV1 FAM135A PKP4 RBMX EPHA2 KIF14 RND1 RRAS2 TFRC PIK3R2 STMN2 PIK3R1 STIP1 ALDH3A2 FRS3 RASAL2 ARHGAP5 MUC13 PLXNA1 GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 97%180292 GAB1 signalosome GAB1 PAG1 PIK3CA PTPN11 AREG TGFA SRC EREG BTC EGF CSK EGFR PIK3R1 HBEGF EPGN PXN DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%9918487 Dengue Virus Genome Translation and Replication DPM1 DPM2 DPM3 IPO7 DNAJC10 EIF4A3 P4HB VIM SCAP MAP1LC3B2;MAP1LC3B-1 KPNB1 OST4 SEC11A UBE2I RPN2 SEC11C OSTC STT3A DNAJA2 RPN1 STT3B RTN3 SUMO1 DNAJC3-1 DDOST KPNA4-1 DAD1 HYOU1 RRBP1 ACOT2;ACOT1 ATL2 SPCS3 SPCS2 SPCS1 MAGT1 YBX1 EIF4A2 NACA EIF4A1 PRKG2 APOA1 KPNA1 EIF4E HSPA5 CANX BAG2 HSPA1A;HSPA1B P4HA1 EIF4G3 P4HA2 EIF4G2 EIF4E3 XPO1 P4HA3 DNAJB11 UBA52 XRN1 SUN2 NPLOC4 UFD1 CALR-1 KPNA7 VCP-1 KPNA5 RPS27A NMT1 KPNA3 TUSC3 KPNA2 UBB;UBC HSPA8 PABPC1;PABPC3 BTF3 FASN EIF4G1 HDLBP PDIA3 TMEM258 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-HSA-8866652.4 Synthesis of active ubiquitin: roles of E1 and E2 enzymes USP9X UBE2H UBE2B UBE2G1 UBE2G2 UBE2W CDC34 UCHL3 USP5 UBE2D3;UBE2D2 UBA1 UBA52 UBE2K UBE2Z UBE2Q2 UBE2D1 UBE2R2 UBE2E3 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S UBE2T UBA6 USP7 OTULIN INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 97%1266695 Interleukin-7 signaling SMARCA4 STAT5A STAT3 PIK3R3 STAT5B TSLP BRWD1 IRS1 RAG2 PIK3R2 RAG1 CRLF2 CISH PIK3R1 IRS2 IL2RG H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 JAK1 IL7R SOCS2 IL7 SOCS1 HGF JAK3 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702596.2 lestaurtinib-resistant FLT3 mutants FLT3 DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME DATABASE ID RELEASE 97%9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin EGF MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5662702 Melanin biosynthesis SLC45A2 OCA2 DCT TYRP1 TYR NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation AP2A2 ATP6V1H CD8B;CD8B2 AP2S1 AP2A1 AP2B1 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69478 G2 M DNA replication checkpoint CDK1 PKMYT1 CCNB2 CCNB1 WEE1 CCNA2-1 CCNA1 TCR SIGNALING%REACTOME DATABASE ID RELEASE 97%202403 TCR signaling CD4 NCK1 PSMD12 PSMD11 PSMD14 PSMD13 LCK EVL PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PLCG1 PSMB1 CSK PSMD1 ADRM1 PSMC2-1 RIPK2 PSMA2-1 PSMA5 SEM1 PSMA6 PAG1 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 IKBKB IKBKG UBA52 CUL1 RPS27A UBB;UBC MAP3K7 UBE2V1 WAS GRAP2 PAK1 INPP5D LCP2 PAK3 TRAT1 UBE2N TAB2 ITK HLA-DPB1-1 HLA-DQB2;HLA-DQB1 CD3E CD3D HLA-DPA1 PDPK1 VASP FYB1 PTEN HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 ENAH HLA-DRA CD3G LAT CD101 TRAF6 PIK3R2 PIK3CB PIK3R1 PIK3CA PLCG2 PTPRJ PTPN22 CDC34 PRKCQ CARD11 BCL10 MALT1 UBE2D3;UBE2D2 NFKBIA PAK2 UBE2D1 RELA PTPRC NFKB1 ZAP70 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 97%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%168325 Viral Messenger RNA Synthesis NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 POLR2E NUP210 POLR2F POLR2H GTF2F1 GTF2F2 NUP93 POLR2L POLR2A NUP205 NUP42 POLR2B POLR2C AAAS POLR2D NUP160 NUP43 NUP85 POLR2G TPR NUP214 NUP88 POLR2I RAE1 RANBP2 NUP155 NUP153 POLR2J;POLR2J2;POLR2J3 NUP35 NUP62 NUP37 NDC1 SEC13 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-5661270.3 Formation of xylulose-5-phosphate DCXR SORD AKR1A1 XYLB CRYL1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 97%69231 Cyclin D associated events in G1 E2F2 CDK6 PPP2R1A ABL1 CDKN1A CDKN1B SKP1 CDK7 CCND1 MNAT1 CKS1B JAK2 CDKN2B LYN PPP2R3B CCND3 CCND2 UBA52 PPP2R2A;PPP2R2D CDKN2D CUL1 CDKN2C PTK6 CDK4 CDK2 PPP2CB;PPP2CA E2F4-1 RPS27A E2F5 CDKN2A PPP2R1B SKP2 UBB;UBC TFDP1 RBL2 TFDP2 RBL1 CCNE2 CCNE1 RB1 CCNH CDKN1C E2F1 E2F3 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 97%9006927 Signaling by Non-Receptor Tyrosine Kinases STAT3 NR3C1 EGF ERBB2 HRAS EGFR RASA1 HIF1A NRAS CDKN1B LRRK2 ARHGAP35 SFPQ-1 RAC1 PELP1 NRG1 CCND1 NRG2 ARAP1 RHOA EREG BTC DOK1 NRG3 NRG4 ELMO1 ELMO2 CRK DOCK1 HBEGF KHDRBS1 KHDRBS2 KHDRBS3 AKT1 UBA52 EPAS1 PXN CBL SOCS3 GPNMB STAP2 PTPN1 SRMS PTK6 CDK4 CDK2 BCAR1 RPS27A UBB;UBC CCNE1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 97%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template UBA7 ISG15 UBE2L6 POLK POLE TRIM25 RFC1 POLD1 PCNA UBA52 POLI POLH USP10 PCLAF USP43 RPA1 SPRTN RPA2 NPLOC4 UFD1 POLD3 POLD4 POLD2 RPA3 VCP-1 RPS27A RFC5 RFC3 RFC4 POLE4 UBB;UBC RFC2 REV1 POLE2 MAD2L2 RCHY1 REV3L POLE3 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-HSA-112303.3 Electric Transmission Across Gap Junctions GJC1 GJA10 GJD2 PANX1 PANX2 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants KIT GLYCOLYSIS%REACTOME DATABASE ID RELEASE 97%70171 Glycolysis NUP133 NUP50 HKDC1 POM121;POM121C NUP54 PGK1 PFKFB2 PFKFB1 PFKFB4 NUP42 PFKFB3 PRKACB-1 ENO1 ENO2 NUP43 ENO3 GNPDA1 ENO4 RAE1 GNPDA2 RANBP2 NUP35 ALDOC ALDOB ADPGK ALDOA NUP37 PRKACA-1 PPP2R1A NUP107 NUP188 BPGM NUP210 PGM2L1 NUP93 PFKL PGAM1 PGAM2 NUP205 PFKM AAAS PFKP GPI NUP160 NUP85 NUP214 TPR NUP88 GCKR NUP155 GCK TPI1 NUP153 PPP2CB;PPP2CA PPP2R5D GAPDH-1 HK2 PPP2R1B HK1 HK3 NUP62 GAPDHS NDC1 SEC13 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC TUBAL3 TUBA1A TUBA1C TUBB1 TUBA8 CCT3 CCT2 CCT8 TUBA3E;TUBA3C-1 CCT7 TUBB2B;TUBB2A CCT5 CCT4 TCP1 CCT6A TUBA4A TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 CCT6B TUBB3;TUBB6 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 97%2022090 Assembly of collagen fibrils and other multimeric structures COL4A5 COL1A1 COL1A2 ITGB4 LOXL3 LOXL4 LOXL1 LOXL2 COL10A1 BMP1 COL9A1 COL27A1 COL9A3 COL9A2 COL18A1 PCOLCE LAMC2 COL2A1 CTSS LOX MMP20 COL4A2 COL4A1 COL4A4 COL6A2 PXDN COL4A3 COL6A1 COL8A2 COL8A1 COL6A3 ITGA6 COL6A6 COL6A5 CTSB CTSV;CTSL PLEC MMP7 CD151 COL11A1 COL11A2 MMP3 MMP9 COL24A1 COL3A1 COL5A1 MMP13 COL5A3 COL7A1 COL5A2 COL15A1 LAMA3 LAMB3 TLL2 TLL1 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 IRF7 UBB;UBC TBK1 TANK TLR3 IKBKE TICAM1 IRF3 OPTN-1 TRAF3 RPS27A UBA52 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E LNPEP CTSS CTSV;CTSL B2M PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis UMPS DHODH CAD DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 97%5579004 Defective CYP26C1 causes FFDD4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.5 Elevation of cytosolic Ca2+ levels P2RX6 ITPR1 P2RX5 ITPR2 P2RX3 STIM1 ITPR3 P2RX2 P2RX1 ORAI2 ORAI1 P2RX7 P2RX4 TRPC7 TRPC6 TRPC3 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 97%417957 P2Y receptors P2RY6 P2RY2 LPAR4 P2RY1 GPR17 P2RY10 P2RY11 LPAR6 P2RY12 P2RY13 P2RY4 P2RY14 SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste KCNJ2 TAS2R7 TAS2R8 TAS2R3-1 GRM4 SCN3A SCNN1G SCNN1D SCN2A TAS2R1 SCNN1B SCN2B TAS2R4 SCNN1A TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 GRM1 CALHM1 OTOP1 TAS2R16 CALHM3 GNG13 SCN9A GNB1 TAS2R40 GNB3 TAS2R41 ITPR3 PRH1-TAS2R14;TAS2R14-3 TAS1R2 TAS1R1 TAS2R39 TAS1R3 GNAT3 TRPM5 PLCB2 SCN4B TRPM4 SCN1B SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 ADAM17 DLL1 JAG2 DLL4 JAG1 ADAM10 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 97%3359471 Defective MMAB causes MMA, cblB type MMAB DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 97%4341670 Defective NEU1 causes sialidosis GLB1 CTSA NEU1 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8874081 MET activates PTK2 signaling LAMA5 MET ITGA3 LAMA3 ITGB1 LAMA2 SRC LAMA4 ITGA2 LAMB3 LAMB2 LAMB1 LAMA1 LAMC3 LAMC2 LAMC1 PTK2 HGF REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 97%174437 Removal of the Flap Intermediate from the C-strand RPA1 RPA2 ACD TINF2 POLD3 TERF2 POLD4 DNA2 RPA3 POLD2 POT1 TERF2IP TERF1-1 FEN1 POLD1 PCNA WRN EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%3928664 Ephrin signaling ARHGEF7 EFNB2 EFNB1 EFNB3 PAK1 RAC1 GIT1 MYL12A PAK3 NCK2 FYN EPHB6 EPHB2 SDCBP EPHB1 EPHB4 PAK2 EPHB3 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling CBL SOCS3 STAT1 TYK2 IL6 PTPN11 IL6ST STAT3 JAK1 JAK2 IL6R OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956551 OTC leader sequence variants cause OTC deficiency OTC SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL SMAD2;SMAD3 FURIN LEFTY2;LEFTY1 CER1 FOXO3 FOXH1 SMAD4 PCSK6 TDGF1 GDF1 MAPK1 MAPK3 ACVR1B CFC1;CFC1B DAND5 ACVR1C NODAL ACVR2B DRAP1 ACVR2A DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation UHRF1 DNMT3B H2AC20 H2AB2;H2AB3;H2AB1 DNMT3A H2AZ2;H2AZ1 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 DNMT1 DNMT3L H2BC5 H2BC1 H2AC14 H2BC21 ISG15 ANTIVIRAL MECHANISM%REACTOME%R-HSA-1169408.4 ISG15 antiviral mechanism NUP133 EIF4A3 NUP50 POM121;POM121C NUP54 KPNB1 NEDD4 NUP42 UBE2N PIN1 NUP43 RAE1 RANBP2 KPNA4-1 IRF3 NUP35 PLCG1 BECN1 IFIT1 JAK1 NUP37 EIF4A2 EIF4A1 USP18;USP41 MX1-1 NUP107 NUP188 EIF4E2 KPNA1 UBA7 EIF4E NUP210 DDX58 ISG15 UBE2L6 HERC5 NUP93 TRIM25 ARIH1 NUP205 EIF4G3 EIF4G2 EIF4E3 AAAS UBA52 NUP160 NUP85 NUP214 TPR NUP88 STAT1 NUP155 NUP153 KPNA7 KPNA5 RPS27A KPNA3 UBE2E1 KPNA2 UBB;UBC EIF2AK2 NUP62 MAPK3 FLNB EIF4G1 PPM1B NDC1 SEC13 RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions CSRP1 SNCB MTF1 MT2A MT3 PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer PTEN THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 97%456926 Thrombin signalling through proteinase activated receptors (PARs) GNA13 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ GNB2 GNB1 ARRB1 GNB4 F2R GNB3 GNGT1 GNA12 F2 GNB5 F2RL2 F2RL3 ARRB2 MAPK1 MAPK3 INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.4 Interconversion of polyamines PAOX SAT1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%879415 Advanced glycosylation endproduct receptor signaling S100A12 HMGB1-1 PRKCSH APP SAA2;SAA1 MAPK1 MAPK3 CAPZA1 DDOST CAPZA2 LGALS3 AGER DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 97%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) PRELP OMD ACAN KERA FMOD LUM B4GALT1 OGN INTERLEUKIN-2 FAMILY SIGNALING%REACTOME%R-HSA-451927.7 Interleukin-2 family signaling SOS1 PIK3CA PTPN6 PTK2B IL21 PIK3R3 STAT3 IL3RA IL2RB GAB2 INPPL1 CSF2RB CSF2RA INPP5D IL5RA GRB2 SHC1-1 IL21R IL9 IL9R STAT4 JAK2 IL15 STAT1 CSF2 LCK STAT5A IL2 STAT5B IL3 SOS2 PIK3CD SYK PIK3R2 HAVCR2 PIK3CB IL5 IL2RA PIK3R1 IL2RG JAK1 LGALS9C;LGALS9;LGALS9B JAK3 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME DATABASE ID RELEASE 97%5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane SLC7A3 SLC25A29 SLC38A3 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC38A1 SLC36A2 SLC6A15 SLC6A14 SLC16A10 SLC6A6 SLC7A6 SLC7A7 SLC7A8 SLC36A4 SLC7A9 SLC7A5 SLC3A2 SLC6A12 SLC43A2 SLC43A1 SLC3A1 SLC1A4 SLC7A11 SLC1A5 SLC6A20 SLC7A10 SLC7A1 PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 97%171306 Packaging Of Telomere Ends H2AC20 ACD H2AB2;H2AB3;H2AB1 TINF2 H2AZ2;H2AZ1 H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 H2AC14 H2BC21 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine ACD TINF2 TDG H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 MBD4 SMUG1 NEIL2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 NEIL3 NEIL1 H2AC20 NTHL1 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 OGG1 H2AC14 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975574 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 97%5609974 Defective PGM1 causes CDG1t PGM1 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVPR2 AVP ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME%R-HSA-561048.6 Organic anion transport by SLC22 transporters SLC22A6 SLC22A12 SLC22A8 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE ARHGEF7 SOS1 GNA13 ARHGEF5 BCL2L11 ARHGEF6 BAD NGEF PSENEN ABR RASGRF2 SQSTM1 PLEKHG2 ARHGEF33 ARHGEF37 ARHGEF38 SOS2 PSEN1 CASP2 NCSTN TRAF6 ARHGEF40 YWHAE FGD1 NGFR FGD2 FGD3 FGD4 ARHGEF26 BEX3 CASP3 PLEKHG5 MCF2 RAC1 ECT2 ARHGEF39 KALRN NET1 UBA52 NGF TIAM1 ARHGEF10L AKAP13 MCF2L ARHGEF11 AATF ARHGEF10 ARHGEF12 MAGED1 VAV3 ARHGEF15 ARHGEF17 RPS27A TRIO ARHGEF16 PSEN2 ARHGEF19 ARHGEF18 UBB;UBC ITSN1 VAV1 APH1A VAV2 APH1B TIAM2 PREX1 ARHGEF3 ITGB3BP ARHGEF4 MAPK8 ARHGEF1 ARHGEF2 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 97%1810476 RIP-mediated NFkB activation via ZBP1 RIPK3 MYD88 NFKBIB RELA NKIRAS1 TLR3 NKIRAS2 NFKB2 CHUK TICAM1 DHX9 RIPK1 NFKB1 IKBKB IKBKG ZBP1 NFKBIA ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC PLA2G4A PLAAT3 PLA2G1B PLBD1 PLA2R1 PLA2G3 PLA2G5 PLA2G10;LOC100652777 PLA2G2F PLA2G6 PLA2G2D PLA2G2E PNPLA8 TMEM86B MBOAT2 LPCAT4 LPCAT3 LPCAT2 LPCAT1 PLB1 PLA2G2A-1 PLA2G12A PLA2G4F JMJD7-PLA2G4B;PLA2G4B PLA2G4D PLA2G4E DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME DATABASE ID RELEASE 97%4551295 Defective ALG11 causes CDG-1p ALG11 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 97%2995410 Nuclear Envelope (NE) Reassembly CDK1 TUBAL3 NUP133 RANGAP1 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 TUBA3E;TUBA3C-1 IST1 KPNB1 VPS4A SPAST CC2D1B UBE2I NUP43 SUMO1 EMD TUBA8 SIRT2 NUP35 RAN NUP37 TUBA1A PPP2R1A LBR NUP107 NUP188 RCC1 BANF1 LEMD3 NUP93 CHMP4C CHMP4B LMNB1 CHMP4A NUP205 TUBA4A PPP2R2A;PPP2R2D NUP160 AHCTF1 TNPO1 NUP85 TUBA1C TUBB1 NUP155 CCNB2 CCNB1 PPP2CB;PPP2CA CHMP2B ANKLE2 CHMP2A TUBB2B;TUBB2A NUP62 VRK1 LEMD2 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 NDC1 SEC13 TUBB3;TUBB6 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) HYAL1 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family MUC17 FCER1G MUC5B MUC20 CLEC6A MUC21 MUC12 MUC15 PLCG2 MUC3A MUC5AC SYK MUC1 FYN MUC2 LYN MUC7 CLEC4A MUC4 CLEC4D MUC6 MUC13 CLEC4E ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 97%2033519 Activated point mutants of FGFR2 FGF20 FGF23 FGFR2 FGF2 FGF7 FGF22 FGF3 FGF10 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease FRS2 GAB1 SOS1 PIK3CA PLCG1 FGFR4 HRAS PIK3R1 NRAS GSD XV%REACTOME DATABASE ID RELEASE 97%3814836 GSD XV GYG1 GYS1 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins DLGAP3 DLGAP4 STXBP1 SHANK2 STX1A SHANK1 NLGN3 NLGN1 NLGN2 EPB41 NRXN3 NRXN2 BEGAIN EPB41L5 GRIN2A EPB41L2 PDLIM5 NLGN4X;NLGN4Y HOMER1 HOMER2 SYT7 GRIN2B SYT12 GRIN1 APBA3 APBA2 APBA1 GRM1 GRM5 EPB41L1 SHANK3 SYT9 SHARPIN CASK LIN7A LIN7C GRIN2C GRIN2D DLG2 DLG3 DLG4 SYT2 SYT1 NRXN1;NRXN3;NRXN2 DBNL SYT10 LIN7B SIPA1L1 LRRTM3 LRRTM4 LRRTM1 LRRTM2 DLGAP1 HOMER3 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME%R-HSA-5619111.4 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%166662 Lectin pathway of complement activation COLEC10 FCN2;FCN1 MASP1 COLEC11 MBL2-1 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 97%9958810 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) TIAM1 CTNND1 FARP2 CBLL1 CDH11 SRC CTNNB1 RAC1 CTSB CTSV;CTSL RPS27A CDC42 CTNNA1 UBB;UBC CDH1 JUP VAV2 ELMO1 DOCK1 ARHGEF4 CTSS UBA52 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) PIK3CD GAB1 PIK3CG PIK3CA PIK3CB EPO EPOR PIK3R1 IRS2 PIK3R5 JAK2 LYN FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis ABL1 ARPC4 ARPC5 WAS ARPC2 ARPC3 YES1 ACTB-1 NCKAP1L MYO9B NCK1 MYH9 ACTR2 ARPC1B ARPC1A WASL ACTG1 CD3G CDC42 SYK FGR HCK FCGR3A;FCGR3B FYN WASF2 WASF3 BAIAP2 NCKIPSD RAC1 MYO10 BTK MYO5A MYO1C ABI2 ELMO1 ABI1 ELMO2 CRK DOCK1 LYN PTK2 ACTR3-1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 VAV1 VAV2 MAPK1 MAPK3 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9663199 Defective DNA double strand break response due to BRCA1 loss of function BARD1 BRCA1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3642279 TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 TGFB1 DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME DATABASE ID RELEASE 97%9853846 Defective ANO6 does not expose PS, PE on the platelet membrane ANO6 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 97%9022534 Loss of MECP2 binding ability to 5hmC-DNA POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 97%597592 Post-translational protein modification DPM1 DPM2 DPM3 ARSD-1 ALPG;ALPP;ALPI-1 IDE BMI1 YY1 RING1 SATB1 RNF2 HDAC7 CBX8 PHC2 RAB4A PHC1 CBX4 CBX2 GCSH-3 PHC3 PNPLA2 NAGK RAB5A AMDHD2 GFPT2 GFPT1 PGM3 CETN2 GNPNAT1 UAP1 CCP110 RENBP OTUD7B ACTR1A TUBA1A TNFAIP3 USP21 USP4 BTRC CYLD APOA2 RAB8A BIRC2 APOA1 SKP1 BIRC3 CDC73 APOA5 LEO1 FBXW11 CSNK1D AXIN2 RAB14 UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 AURKA CSF1 MAN2A2 MGAT3 ST8SIA6 CHST8 CAMKMT ST8SIA2 FUCA1 ST8SIA3 RPS27A UBB;UBC DYNC1H1 TUBB4B HSP90B1 TUBB4A;TUBB;TUBB8B;TUBB8 TNIP2 CDK1 LHB PRKDC TMEM129 HLTF RNF152 SHPRH PEX10 PEX2 PEX12 PEX13 PEX14 RNF40 RNF144A SELENOS WAC-1 RNF181 RAD18 INS;INS-IGF2 ADAM10 ADAMTS16 ADAMTS18 PLAUR LAMC1 ADAMTS4 ADAMTS5 GALNT2 ADAMTS1 TIMP1 ADAMTS8 ADAMTS9 FOXO4 ATXN3 OTUB2 OTUD5 OTUD7A FBXO32 VCPIP1 TNIP3-2 ZRANB1 YOD1 RNF128 TNIP1 OTUB1 FURIN SPP1 LAMB1 HK1 DBT TRAPPC2L RAB32 RAB31 TBC1D20 RAB35 H2AC14 TRIM28 RAB38 L3MBTL2 TGFA RAB6B HCFC1 TRAPPC3 TRAPPC1 SATB2 TRAPPC4 TRAPPC5 OGT-1 PPARGC1A RAB39A CREBBP RAB27A RAB39B RAB27B TRAPPC9 SMAD2;SMAD3 ADRB2 H2AC20 RAB8B TRAPPC2;TRAPPC2B RAB33A TRAPPC6A TRAPPC6B RAB7B RAB1A RAB1B RAB21 NCOA1 NCOA2 CHML GPIHBP1 TRAPPC10 ACTL6A RAB33B-1 RAB11B RAB10 RAB13 RAB18 UBE2D3-1 ARF1 NCOR2 KAT2B KAT2A SUZ12 H2BC5 SUMF2 MCRS1 PCGF2 SUMF1 H2BC1 MITF IGFBP1 EP300 MEN1 H2AC4 CLSPN DNMT1 SUDS3 CBX5 PENK ACTB-1 TADA3 CHD3 SIN3A H2BC21 PARP1 ZNF350;ZNF432 DNMT3B SRD5A3 WDR5 DNMT3A KCTD6 SMAD1 SMAD4 SMURF2 SMAD7 HDAC2 THBS1 HDAC1 ST6GALNAC5 MTA1 ST6GALNAC6 RBBP5 TDG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 PROS1 H2BC15;H2BC3;H2BC11;H2BC12 FGA FGG F2 NOTUM F5 F7 F8 F9 SERPINC1 KNG1 SERPIND1 F10 FUCA2 PROC EIF2AK2 TOPORS POMT2 ARSA SEMA5A SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 C1GALT1C1 ADAMTS2 ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ARSL ADAMTS7 ARSJ SBSPON ARSK MUC3A MUC5AC ARSH ADAMTS20 ARSI B3GLCT ST8SIA5 ADAMTS12 ARSG CFP THBS2 THSD1 CTSA THSD4 ADAMTS10 ADAMTS15 ADAMTS14 BPIFB2 MUC1 MUC2 ADAMTS19 ADAMTS17 RPL27A MUC7 MUC4 MUC6 PSMD12 GALNT3 MUC17 PSMD11 C1GALT1 PSMD14 MUC5B PSMD13 MUC20 MUC21 PSMA7 DNAJC3-1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PALB2 PSMD3 ANK3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 KDM8 AHSG PSMC3 OGFOD1 PSMA1 JMJD4 PSMC4 DHPS PSMC1 FN3KRP JMJD7 RCCD1 RAB3D EIF5A2 DNAJC24 RAB44 DPH1 DPH2 DPH5 DPH6 DPH7 ZC3H15 FN3K RAB37 RWDD1 ICMT RAB4B EIF5A;EIF5AL1 DOHH RAB24 RIOX1 DRG1 DRG2 NUP214 COPB1 CD59 CD55 HSPA8 MVD ASPH RBX1 MAT2B QSOX1 MBTPS1 POLB CTSZ RPL8 SLC35A1 SLC35A4 FKRP B4GAT1 CRPPA CHST10 DAG1 RXYLT1 LARGE1 LARGE2 POMGNT1 FKTN FCGR3A;FCGR3B SMC5 PARK7 SMC6 CUL3 DDX17 NSMCE3 FDX1 NSMCE2 NSMCE1 HIC1 EID3 ZBED1 KBTBD7 USP18;USP41 TP53BP1 SP3 C3-1 TOP2A TOP2B NUP107 ZNF131 NUP188 SENP5 FOXL2 SENP2 SAFB NSMCE4A TOP1 SP100 USP14 UHRF2 NUP210 RNF168-1 CASP8AP2 NOP58 RWDD3 MBD1 NUP93 RAD52 NUP205 UBXN1 NGLY1 MLEC AAAS ENGASE NUP160 ARRB1 NUP85 TPR NUP88 NUP155 XRCC4 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 NUP153 RCE1 NAPA RAB5C TGOLN2 CDH2 ELOC-1 NUP62 ELOB NDC1 SEC13 LIPT2 USP8 NFU1 LIPT1 NUP133 LIAS PIGS CPM LY6K PIGU GOLGB1 PGAP1 RANGAP1 PIGT NUP50 PSCA POM121;POM121C PIGO PIGN NUP54 GPAA1 PIGP PIGZ MSLN PIGW PIGV PRSS21 PRND TECTB IZUMO1R RTN4RL2 PIGC CISH PIGB NUP42 NRN1L RTN4RL1 CD109 PIGA SOCS2 LY6D PIGK NUP43 PIGM SPACA4 TAF9B PIGL PIGG RAE1 LY6H RANBP2 PIGF GPLD1 PIGH NRN1 NTM TEX101 TAF10 LYPD1 LYPD2 LYPD3 LYPD4 THY1 LYPD5 ART3 LYPD8 NUP35 ARRB2 ART4 ALB OTOA LY6G6C OPCML NTNG1 NTNG2 UBE2T NEGR1 CNTN5 NUP37 PIGX-1 LSAMP COP1 GP2 PLET1 PRSS41 XPNPEP2 LYPD6B ALPL VCAN CNTN3 MELTF GLB1 CNTN4 TECTA;TBCEL-TECTA MDGA2 RECK MDGA1 SPRN ARSB DDX58 IFIH1 TRIM25 FOLR2 IKBKG LRR1 CCNF KEAP1 HERC2 GALNT11 GALNT14 AMER1 GALNT13 GALNT16 FBXO7 GALNT15 AXIN1 FBXO9 GALNT18 B3GALNT2-2 GALNT10 POFUT2 WSB1 FBXO2 EMID1 GALNT9;GALNT17 RNF123 APC FUT10 FUT11 GALNTL5 UBE2J2 GALNTL6 B3GNTL1 GALNT9 VDAC1 GALNT8 POMGNT2 B3GNT9 SIAH2 B3GNT8 MMRN1 B3GNT6 MMRN2 CHST4 FBXL8 GCNT1 FBXL4 GCNT3 FBXL7 GCNT4 GALNT7 GALNT6 GALNT5 GALNT4 MGAT5B-1 A4GNT POMK GAN PRKN GATA3 GPR75-ASB3;ASB3-1 KLHL2 RAB2A KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 KBTBD8 SPSB4 FBXO27 UBE2Z FBXO21 FBXO22 DLAT BMP4 FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 B3GNT7 B3GNT5 B3GNT4 LMO7 FBXO10 FBXO11 B3GNT3 PSME1 KLHL41 B3GNT2 SEC22B KCTD7 PSMB10 PSMB8 KLHL42 PSMB9 UBE2V2 HIF1A CUL7 CUL5 UBA6 MYC CUL2 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H UBE2B KLHL25 ZBTB16 ALG5 NUDT14 TGFB1 KLHL21 KLHL22 BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBA3 TFAP2C UBA1 UBE2K TFAP2E;TFAP2B KBTBD13 UBE2Q2 GMPPB UBE2D1 FPGT RELA GMPPA GFUS DHRSX B4GALT2 GMDS PMM1 B4GALT3 UBE2R2 FCSK VGF DOLPP1 ALG10;ALG10B CDKN2A UBE2C ASB13 UBE2E1 ASB14 IL6 GOSR1 ASB11 UBE2S RNF7 ASB12 ASB17 ASB18 FBXL22 ASB15 ASB16 COG8 FBXL20 COG7 COG6 COG5 COG4 COG3 ASB10 COG2 SPTBN2 BET1L RAB30 RAB36 FBXL19 FBXL18 FBXL15 APOL3;APOL4;APOL1;APOL2 FBXL16 FBXL13 B4GALT6 FBXL14 CTSC FBXL12 B4GALT4 B4GALT5 ASB8 ASB9 ASB6 CAPZA3 ST6GAL1 ACTR10 ASB7 MOGS ASB4 ASB5 ASB2 RPN2 SAR1B ASB1 SDC2 RPN1 ST3GAL4 GOLGA2 DCTN6 CDC25A DCTN5 ST3GAL1 DCTN4 ST3GAL2 ST3GAL3 APP EDEM2 NFKB2 GRIA1 TOMM20 VDAC2-1 NSF SKP2 VDAC3 RPS23 MAGT1 IKBKE TOMM70 RIPK2 ANO8 AREG NFE2L2 EEF1A1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 EEF2 CANX RNF135 UCHL1 SENP8 UCHL3 FOXK2 MGAT5 FOXK1 MBD5 GPC3 MBD6 ASXL1 ASXL2 MGAT1 BAP1 RPS2 MGAT2 SEC24D-1 VCP-1 TUSC3 MAP3K7 RPS6 OTULIN TMEM258 DDX5 ANK1 FUT8 MAN2A1 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E CAPZB OST4 MAN1A2 MAN1C1 MAVS OSTC MAN1A1 USP30 SQSTM1 STT3A UBE2N STT3B TAB1 ST6GALNAC2 TRIM27 USP10 PRKCSH USP13 TNKS MGAT4A-1 TNKS2 RNF146 OTUD3 DDOST DAD1 TRAF3 TRAF6 ST6GALNAC1 CMAS MAN1B1 NPL ST6GALNAC3 NANP ST6GALNAC4 NEU4 BECN1 ST8SIA4 SEC23A NANS ST6GAL2 ST8SIA1 NOD1 GNE NOD2 CAPZA1 GANAB CAPZA2 VHL SEC24B SEC24A GALNT1 MGAT4C KDELR2 MGAT4B COPB2 SEC24C COPA COPE TMED3 TMED7 TMED9 COPZ2 DCAF13 HGS CALM3;CALM1 COPZ1 RAB7A ARF5 DCAF7 ARCN1 COPG2 TUBA1C COPG1 TUBB1 FBXO4 METTL21A FBXO6 KIN METTL22 ETFBKMT VCPKMT FAM86B1;EEF2KMT;FAM86B2 FBXW4 EEF1AKMT2 PSME2 EEF1AKMT1 FBXW10;CDRT1 FBXW5 TUBB2B;TUBB2A FBXW7 MUL1 FBXW9 FBXW2 ARFGAP1 PREB KDELR3 TUBB3;TUBB6 PSMD9 PSMD4 PSMD5 PAAF1 PSME3 PSME4 PSMD10 PSMB11 TUBA3E;TUBA3C-1 POMP PSMA8 PSMF1 PSMG3 GOSR2 PSMG4 PSMG1 PSMG2 USP5 USP3 FKBP8 MDC1 SNX3 USP37 USP34 USP47 HIF3A USP48 USP49 USP42 FBXL3 USP44 PTRH2 DAXX USP26;USP29 ARF4-1 FBXL5 USP16 WDR20 RRAGA USP24 USP25 USP20 IGFBP7 USP28 WFS1 B4GALT1 TMED2-1 CALU BARD1 SEL1L ST3GAL6 RAB6A UBXN7 SPP2 CDKN1A PDIA6 DPP3 APLP2 CHM BRCA1 SCG3 ING2 RHOA BABAM1 BABAM2 UIMC1 ABRAXAS1 BRCC3 DDB2 GBF1 PCNA WRN EPAS1 RAB11A SOCS3 RPA1 NPLOC4 UFD1 UBA2 HIPK2 SAE1 VNN1 LTBP1 VNN2 USP7 IGFBP3 USP2 BLM MDM2-2 NPM1-2 CHRDL1 MIA2 UCHL5 MIA3 TMEM115 USP15 FSTL1 FSTL3 MDM4 DCAF8 DCAF5 DCAF6 U2AF2 WSB2 DCAF4;DCAF4L2;DCAF4L1 COMMD5;LOC101928879 OBSL1 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 COMMD8 COMMD9 TPGS1 TTL PUM2 DDA1 TPGS2 SVBP ANKRD9 COMMD2 ARPC4-TTLL3;TTLL3 COMMD3 TTLL12-1 AGTPBP1 COMMD1 LRRC49 COMMD6 RABGGTB NICN1 COMMD7 RABGGTA COMMD4 VASH2 SPSB3 VASH1 CCDC8 AGBL5 TTLL7 BIRC5 CUL9 AGBL4 UBD TTLL6 NAE1 TTLL5 SOCS6 SMC3 TTLL4 SOCS5 AURKB RAD21 AGBL1 WDTC1 AGBL3 CCDC22 TTLL1 DCUN1D2-1 COMMD10 AGBL2 STAG1 DTL TTLL11 TTLL9 TULP4 STAG2 SMC1A DCAF16 PML DCAF17 CAND1 FEM1C DCAF10 DCAF11 NRIP1 FEM1A TRRAP FEM1B TRAF2 NEURL2 ERCC8 JMJD6 RIPK1 CDC34 TADA2B NFRKB BCL10 ACTR5 RAD23A UBE2D3;UBE2D2 ACTR8 NFKBIA RAD23B DDB1 INO80C PRMT3 INO80B INO80E INO80D COPS7B COPS7A XPC TFPT INO80 H2AC16;H2AC11 TGFBR1-1 CUL4A COPS3 KDM1B TGFBR2 COPS6 COPS5 RUVBL1 COPS8 CUL4B PCSK9 FGF23 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L P4HB ATXN7 APOB CDC20 CCNA2-1 CCNA1 RIOX2 USP33 ETF1 H2BC18 MFGE8 USP22 CST3 SLC35C1 MUC13 JOSD2 CKAP4 JOSD1 KTN1 COL7A1 RAB3A ADAMTS13 DLST EDEM3 AMFR SYVN1 DERL2 EDEM1-1 RNF5 RNF103 OS9 RNF139 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 MRTFA TF ABRAXAS2 TPST2 MYSM1 STAMBPL1 DYNC1LI1 TPST1 DYNC1LI2 STAMBP CDCA8 IL33 RHOT1 HNRNPC LRRC41 PTEN FN1 INCENP ETFB UMOD ASGR1 ASGR2 MANEA GPS1 LY6E LMAN1 STX5 YKT6 USP9X ALG8 ALG9 MCFD2 LGALS1 ALG6 AMELY;AMELX ALG2 SERPINA1 ALG3 EVA1A PPP6C PPP6R1 CCN1 ALG1 PPP6R3 CHGB IGFBP5 LMAN1L GORASP1 IGFBP4 SEC22A SEC22C SHISA5 NAPB MXRA8 TMED10 SPARCL1 STX17 LMAN2L USO1 SCG2 NAPG LMAN2 STC2 SEC31B ANKRD28 AMBN SEC23IP DHDDS TMEM132A HRC CNIH1 CRYZL2P-SEC16B;SEC16B PRSS23 BMP15-1 CNIH2 STS MEPE FOLR1 RCN1 CNIH3 ENAM BET1 AMTN VWA1 FAM20C FAM20A ITIH2 AFP GOLM1 NUCB1 TFG SPTB NEU2 NEU3 CTBP1 WDR61 NEU1 APOE HNRNPK B4GALNT2 WDR48 GAS6 ANK2 BST1 COPS4 RAB5B COPS2 SPTBN4 SPTBN5 RAB22A RAB40C RAB3B RAB3C RAB42 RAB2B RAB34 PTP4A2 RAB20 RAB25 RAB26 ARFGAP3 RAB23 RAB29 COG1 ARFGAP2 RAB15 RAB19 RAB17 SPTA1 DMP1 RNF20 ALG14 ALG12 ALG11 MATN3 NDUFAB1 TNC CFTR RFT1 LOC110384692;C4A;C4B_2;C4B SCFD1 SPTBN1 FBN1 STAM PMM2 CP SPTAN1 CALR-1 LAMB2 GGCX KDELR1 CTR9 RTF1 SEC31A PAF1 DYNC1I1 PIAS4 DERL1 HDAC4 PIAS3 DPAGT1 UBE2I THRB MPI VDR NR1H2 RORA NR3C1 RAB9A ESR1 NR2C1 PIAS1 NR3C2 RAB9B DOLK NR4A2 NR5A1 AR RXRA SUMO1 SUMO3 SUMO2 RARA PGR PPARG DCTN1 PPARA TP53 STAM2 ST3GAL5 CGA MPDU1 FUT6;FUT5;FUT3 NUS1 SENP1 SLC17A5 PDIA3 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 97%6804758 Regulation of TP53 Activity through Acetylation HDAC1 PML KAT6A RBBP4 AKT2 AKT3 MAP2K6 ING5 BRPF1 ING2 RBBP7 MTA2 BRD1 CHD4 CHD3 MBD3 BRPF3-1 PIN1 AKT1 PIP4P1 BRD7 GATAD2B GATAD2A PIP4K2A PIP4K2B PIP4K2C EP300 MEAF6 TP53 HDAC2 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-HSA-5357769.5 Caspase activation via extrinsic apoptotic signalling pathway CASP3 TICAM2 DAPK1-1 TRADD DAPK2 LY96 DAPK3 FASLG TRAF2 APPL1 MAGED1 TICAM1 CASP8 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A UNC5A CD14 DCC FADD UNC5B TLR4 CASP9 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS SOS1 SHC1-1 EPO RAPGEF1 VAV1 HRAS EPOR IRS2 CRKL JAK2 LYN NRAS PROTEIN REPAIR%REACTOME%R-HSA-5676934.4 Protein repair TXN MSRA PCMT1 MSRB3 DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 CBLIF AMN CUBN BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9915355 Beta-ketothiolase deficiency ACAT1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation PPP2R1A CAMK2G MRAS MARK3 PPP1CC MAP3K11 ARAF CALM3;CALM1 RAF1 YWHAB JAK2 PPP2CB;PPP2CA SRC PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E MAP2K2;MAP2K1 HRAS BRAF PHB KSR1 SHOC2 CAMK2B CAMK2D BRAP CAMK2A PPP1CB NRAS SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.7 Scavenging by Class B Receptors HMGB1-1 SAA2;SAA1 PRDX1 CD5L SSC5D CD36 APOB APOA1 S100A9 SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors SPARC STAB1 STAB2 APOB ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding IZUMO3 IZUMO2 IZUMO4 CD9 ACR IZUMO1-1 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders ABCG5 ABCC8 ABCC6 ABCC9 DERL3 DERL1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 ABCD1 PSMB7 PSMD6 ABCB4 PSMB4 PSMD7 ERLEC1 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 ABCA12 PSMB1 PSMD1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 ABCA1 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 APOA1 CFTR KCNJ11 ABCB6 ABCA3 UBA52 ERLIN1 ERLIN2 ABCD4 ABCB11 VCP-1 RPS27A DERL2 RNF5 UBB;UBC OS9 LMBRD1 RNF185 ABCG8 ABCC2 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5603041 IRAK4 deficiency (TLR2 4) S100A8 FGG TLR2 MYD88 LY96 IRAK4 BTK TLR6 S100A1 CD14 HMGB1-1 TIRAP TLR4 CD36 TLR1 FGB FGA S100A9 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane S100A8 TLR2 DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 SOCS1 APP NFKB2 TLR6 CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK BTK FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B S100A1 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 SIGIRR IRAK3 FGB NFKBIA FGA FGG RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 S100A9 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.2 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes SOCS3 RUNX1 SERPINB13 CTSK SOCS4 CTSV;CTSL CBFB TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer TGIF1-1 HDAC1 SNW1 CCNK UBE2D3-1 USP9X CCNT1 NCOR2 CDK8 WWTR1 NCOR1 COL1A2 CCNC-1 NEDD4L CDKN2B SP1 UBA52 PARP1 SMAD2;SMAD3 UBE2D1 FURIN PPM1A ATP1B4 CDK9 TGIF2 SKI EP300 CCNT2-1 E2F4-1 RPS27A E2F5 SMAD4 MEN1 SMURF2 UBB;UBC SERPINE1 TFDP1 JUNB SMAD7 RNF111 TFDP2 MAPK1 RBL1 MAPK3 YBX1 SKIL MYC TRIM33 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 97%9711097 Cellular response to starvation RPS14 RPS17 RPS16 DEPDC5 RPS19 RPS18 RPS11 RPL10A GCN1 RPS10 RPS13 RPS12 BMT2 SEH1L ATF2 WDR59 RPL27A MIOS WDR24 RRAGA RRAGC RRAGB RRAGD RPL10;RPL10L-1 RPS25 RPS27 RPS29 ASNS RPS20 RPS21 RPS24 RPS23 RPL36AL-1 CEBPG FNIP1 FNIP2 RPL7A C12orf66 ITFG2 KPTN ATP6V1E1 SZT2 ATP6V1E2 ATP6V1G1 ATP6V1G2 RPLP0 FLCN RPTOR RPLP2 RPL36-1 RPL35A RPS27L RPS15A ATP6V0D1 ATP6V0D2 ATP6V1A RPS3 UBA52 RPS2 ATF4 ATP6V1D ATP6V1C1 ATP6V1F ATP6V1C2 RPL18A FAU ATF3 RPL12-1 RPS27A LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 RPS9 LAMTOR5 RPS7 RPS8 RPS5 SESN2 RPS6 TCIRG1 RPSA ATP6V0B ATP6V1B2 ATP6V0C ATP6V1B1 RPL22L1 DDIT3 SLC38A9 RPL37A-1 RPL26L1 RPL4 RPL30 ATP6V1G3 RPL3 RPL32 RHEB RPL31 RPL34 RPL8 RPL9 RPL6 ATP6V0E2;ATP6V0E1 RPL7 RPS4X RPL35 RPL38 RPS3A MLST8 RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 MTOR RPL15-1 EIF2S2 EIF2S3;EIF2S3B EIF2S1 RPL3L RPL5-1 ATP6V1H RPLP1-2 NPRL2 NPRL3 EIF2AK4 CEBPB RPL23A TRIB3 CASTOR1 CASTOR2 SESN1 IMPACT RPL11 RPL14 SH3BP4 RPL13 RPL18 RPL17 RPL19 RPS15 SEC13 INTERLEUKIN-17 SIGNALING%REACTOME%R-HSA-448424.8 Interleukin-17 signaling UBE2V1 MAP2K6 IRAK1 IRAK2 DUSP4 DUSP3 VRK3 DUSP6 IL17C DUSP7 UBE2N ATF2 IL25 TAB3 TAB2 TAB1 TRAF6 NOD1 NOD2 RIPK2 JUN PPP2R1A MAPK7 IL17RC BTRC IL17RA SKP1 CHUK IL17RE FBXW11 IL17RB IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA IL17F PPP2R5D ATF1 RPS27A ELK1 IL17A RPS6KA3 PPP2R1B RPS6KA5 RPS6KA2 UBB;UBC NFKB1 RPS6KA1 MAP3K7 MAP2K2;MAP2K1 MAP3K8 MEF2A MAP2K3 MAPK1 MAPK14 MAP2K4 MEF2C MAPK3 MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination ATXN7 CDC20 CCNA2-1 CCNA1 IDE USP33 YY1 H2BC18 PSMD12 PSMD11 USP22 PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 TOMM20 PSMB7 PSMD6 VDAC2-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 VDAC3 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 TOMM70 ADRM1 CCP110 PSMC2-1 RIPK2 PSMA2-1 PSMA5 OTUD7B SEM1 PSMA6 PSMC5 TNFAIP3 PSMA3 PSMC6 USP21 PSMA4 USP4 PSMC3 CYLD PSMA1 PSMC4 PSMC1 BIRC2 BIRC3 JOSD2 JOSD1 UCHL1 RNF135 SENP8 AXIN2 UCHL3 FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 BAP1 UBA52 VCP-1 RPS27A UBB;UBC MAP3K7 TNIP2 CDK1 ABRAXAS2 MYSM1 STAMBPL1 STAMBP MAT2B IL33 RHOT1 NLRP3 POLB MAVS USP30 TAB1 USP10 USP13 TNKS TNKS2 RNF146 OTUD3 PTEN TRAF3 TRAF6 BECN1 NOD1 NOD2 USP18;USP41 USP9X FOXO4 USP14 ATXN3 HGS OTUB2 OTUD5 OTUD7A VCPIP1 TNIP3-2 ZRANB1 YOD1 RNF128 TNIP1 OTUB1 ARRB1 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RCE1 MUL1 WDR48 H2AC14 USP8 HCFC1 OGT-1 USP5 USP3 FKBP8 SNX3 USP37 USP34 USP47 USP48 TAF9B USP49 USP42 USP44 PTRH2 ADRB2 SMAD2;SMAD3 USP26;USP29 USP16 WDR20 H2AC20 USP24 USP25 USP20 TAF10 USP28 ARRB2 BARD1 ACTL6A KAT2B BRCA1 KAT2A CFTR DDX58 RHOA IFIH1 BABAM1 BABAM2 TRIM25 UIMC1 ABRAXAS1 IKBKG BRCC3 STAM DDB2 H2BC5 MCRS1 H2BC1 KEAP1 UFD1 AXIN1 EP300 RNF123 APC H2AC4 CLSPN VDAC1 SIAH2 USP7 USP2 MDM2-2 SUDS3 PRKN GATA3 ACTB-1 TADA3 UCHL5 USP15 ESR1 MDM4 H2BC21 AR SMAD1 SMAD4 SMURF2 TP53 SMAD7 HIF1A MYC STAM2 TRRAP TRAF2 TGFB1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RIPK1 TADA2B NFRKB ACTR5 H2BC15;H2BC3;H2BC11;H2BC12 RAD23A NFKBIA ACTR8 RAD23B INO80C INO80B INO80E UBE2D1 INO80D TFPT INO80 H2AC16;H2AC11 TGFBR1-1 KDM1B TGFBR2 RUVBL1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 97%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 CDC20 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 AURKB PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 AURKA ANAPC10 ANAPC11 PTTG1;PTTG2 FZR1 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 RB1 ANAPC1 ANAPC2 PLK1 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events PLA2G4A GNA14 GNA15 ADCY9 PRKAR1B GNA11 PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 GNAQ PRKAR2A PRKCG ITPR1 ITPR2 ITPR3 CAMK4 PDE1C CAMKK1 GRK2 CAMKK2 GNAT3 GNAI1 GNAI3 GNAI2 CAMK2B CAMK2D CAMK2A PRKACA-1 CAMK2G CALM3;CALM1 GNAL PRKCD NBEA PRKCA PRKAR2B PLCB3 PLCB4 PLCB1 AHCYL1 PLCB2 KPNA2 PRKX MAPK1 PDE1B PDE1A TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.3 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA DIS3 XRN1 MAPKAPK2 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 YWHAB DCP1A ZFP36 TNPO1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%445355 Smooth Muscle Contraction MYL6 CALD1 CAV3 ITGB5 PAK1 MYH11 CACNA1H TRIM72 DYSF MYL12A LMOD1 CALM3;CALM1 MYL12B ANXA1 PAK2 PXN VCL ANXA2 ITGA1 MYL5 MYL7 TLN1 MYL10 TPM4 TPM3 MYLPF MYL6B ANXA6 ALDH2 MYLK SORBS1 GUCY1A2 SORBS3 PDE5A CACNA1G GUCY1A1 GUCY1B1 CACNA1I TPM2 TPM1 ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.6 ESR-mediated signaling TGFA PIK3R3 GNG10 MED1 GNG2 AKT2 GNG5 NOS3 AKT3 GNG4 GNG8 GTF2A1 PTGES3-1 GTF2A2 YY1 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNG13 POLR2B POLR2C CREBBP GNB2 ATF2 POLR2D GNB1 GNB4 POLR2G KDM4B KAT5 GNB3 POLR2I GNB5 H2AC20 GPAM H2AB2;H2AB3;H2AB1 SRC POU2F1 SRF EGF GNAI1 EGFR GNAI2 NCOA1 NCOA2 PRMT1 NCOA3 JUN AREG CDKN1B KAT2B H2AJ HSP90AA1 NR5A2 EREG TLE3 BTC ZDHHC7 FOS FKBP5 CAV2 HBEGF PTK2 XPO1 H2BC5 MYB AKT1 PPP5C H2BC1 KDM1A AXIN1 EP300 ELK1 KPNA2 H2AC4 BCL2 STRN DDX5 GATA3 PRKCZ CAV1 CITED1 ESR1 SP1 H2BC21 HSP90AB1 ZDHHC21 TBP PDPK1 PGR CARM1 KCTD6 H2AZ2;H2AZ1 GNAT3 PIK3R2 ESR2 PPID HRAS GNAI3 PIK3R1 FOXA1 SMC3 FKBP4 MYC RAD21 JUND GREB1 NRAS STAG1 CXCL12 STAG2 HDAC1 SMC1A PIK3CA TFF1 KANK1 TNRC6C MOV10 CXXC5 TFF3-1 TNRC6A-1 AGO4 NRIP1 CCNT1 AGO2 USF2 USF1 CTSD AGO3;AGO1 ZNF217 FOSB TNRC6B EBAG9 FOXO3 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 MMP7 POLR2E CBFB POLR2F GTF2F1 MMP2 POLR2H GTF2F2 RUNX1 MMP3 CALM3;CALM1 MMP9 S1PR3 POLR2L H2BC15;H2BC3;H2BC11;H2BC12 IGF1R UHMK1 EPGN GNGT1 CDK9 POLR2J;POLR2J2;POLR2J3 SPHK1 MAPK1 MAPK3 H2AC14 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) GLB1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 97%5654708 Downstream signaling of activated FGFR3 FRS2 FGF20 GAB1 SOS1 PIK3CA FGF23 PTPN11 FGF2 PLCG1 HRAS PIK3R1 FGF1 FRS3 FGF4 FGF16 NRAS FGF9 FGF18 GSD II%REACTOME%R-HSA-5357609.5 GSD II GAA GYG1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 97%71240 Tryptophan catabolism IDO2 ACMSD IDO1 AFMID KYAT3 SLC36A4 SLC7A5 TDO2 KYAT1 KYNU SLC3A2 AADAT KMO HAAO EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 97%168274 Export of Viral Ribonucleoproteins from Nucleus NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 NUP210 NUP93 NUP205 HSPA1A;HSPA1B NUP42 AAAS XPO1 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 RAN NUP37 NDC1 SEC13 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802948 Signaling by high-kinase activity BRAF mutants MARK3 ARAF RAF1 CNKSR2 YWHAB ITGB3 CNKSR1 PEBP1 FGB FGA ARRB1 VCL FGG ITGA2B TLN1 VWF SRC FN1 IQGAP1 ARRB2 MAP2K2;MAP2K1 RAP1A CSK MAPK1 HRAS BRAF MAPK3 KSR1 KSR2 RAP1B NRAS APBB1IP INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling IL1RAPL1 IL1F10 MAPK8 IL1RL2 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling PTGES3-1 HSP90AB1 ARNT2 AIP ARNT AHRR AHR RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination CPSF1 NCBP1 LSM10 CPSF3 LSM11 SNRPF PAPOLA SNRPB SNRPD3 SYMPK CPSF7 PABPN1-1 FIP1L1 SNRPE-2 SLBP ZNF473 CSTF3 CSTF2 NCBP2-1 CSTF2T PCF11 CPSF2-1 NUDT21 CLP1 SNRPG-2 WDR33 CPSF4 STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels TSC22D3 TRDN ASPH STOM STOML3 CLCN3 CLCN2 CLCN1 BSND SGK3;C8orf44-SGK3 TPCN2 TPCN1 CLCN7 SGK1-1 CLCN6 CLCN5 CLCN4 OSTM1 FKBP1B UNC79 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 TRPC7 TRPC5 MCOLN3 TRPC6 TRPC3 TRPA1 TRPC4 TRPC1 TRPV2 TRPV3 ANO8 TRPV1 BEST2 ANO9 MCOLN1 BEST3 ANO6 TRPC4AP SLC9C2 MCOLN2 BEST1 ANO4 TRPV6 BEST4 TRPV4 TRPV5 ANO5 ANO2 ANO3 ANO1 SLC9B1 SLC9B2 SCNN1G CLCA4-1 SRI SCNN1D CALM3;CALM1 SCNN1B SCNN1A RAF1 TTYH3 TTYH2 NEDD4L ANO10 WNK4 NALCN ASIC4 UBA52 ASIC5 WWP1 CLCA2 CLCA1 ASIC2 ASIC3 ASIC1 RPS27A UBB;UBC WNK1 WNK3 RYR1 RYR2 RYR3 UNC80 CLCNKA;CLCNKB CLIC2 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%416700 Other semaphorin interactions PLXNC1 SEMA6A SEMA6D PLXND1 ITGA1 SEMA7A ITGB1 SEMA3E TREM2 PLXNA2 SEMA4A CD72 SEMA4D TYROBP PTPRC PLXNB3 SEMA5A PLXNA4 PLXNA1 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA TET3 TET2 TET1 TDG CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-HSA-209905.3 Catecholamine biosynthesis DDC PNMT TH DBH REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 NQO1 PSMA1 PSMC4 PSMC1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 ODC1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 OAZ1 PSMD3 PSMB1 PSMD1 ADRM1 AZIN1-2 PSMC2-1 PSMA2-1 PSMA5 SEM1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) RHOA LINGO1 ARHGDIA MAG OMG RTN4 NGFR MCF2 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway POLB APEX1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle MAOA STX1A SLC38A2 ARL6IP5 NAAA APBA1 GAD1 GAD2 SNAP25 GLS SLC18A3 DNAJC5 GLS2 SLC22A2 SLC22A1 SLC17A7 TSPOAP1 SLC5A7 CHAT CASK LIN7A LIN7C UNC13B SLC32A1 RAB3A SLC6A13 ABAT SYT1 SLC6A1 SYN3 VAMP2 ALDH5A1 CPLX1 SYN2 SYN1 RIMS1 PPFIA1 PPFIA4 SLC18A2 PPFIA3 PPFIA2 SLC6A12 SLC6A11 SLC1A1 HSPA8 SLC1A2 SLC1A3 LIN7B SLC1A6 SLC1A7 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%73762 RNA Polymerase I Transcription Initiation HDAC1 TAF1D MTA1 TAF1B RBBP4 RRN3 TAF1C KAT2B TAF1A KAT2A CDK7 POLR2E POLR2F POLR2H MNAT1 RBBP7 MTA2 MTA3 POLR2L CHD4 CHD3 MBD3 ERCC3 ERCC2 GTF2H1 GTF2H3 ERCC6 UBTF GTF2H4 GATAD2B GATAD2A TBP TTF1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 CCNH EHMT2 HDAC2 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%8868766 rRNA processing in the mitochondrion TFB1M MTERF4 NSUN4 TRMT10C RPUSD4 PRORP RPUSD3 TRUB2 MTERF3 RCC1L NGRN HSD17B10 MRM2 MRM3 FASTKD2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.2 Erythrocytes take up oxygen and release carbon dioxide HBA2;HBA1 CA1 AQP1 CA2 CA4 HBD;HBB RHAG SLC4A1 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling NGF CASP3 YWHAE NGFR CASP2 BEX3 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME%R-HSA-9702506.3 Drug resistance of FLT3 mutants FLT3 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair CCNA2-1 CCNA1 YY1 KDM4A PSMD12 POLI KDM4B POLH PSMD11 PSMD14 PSMD13 PSMA7 NTHL1 MUS81 PSMD8 C1orf112 EME1-1 BRCA2 PSMB6 PSMB7 RAD51AP1 PSMD6 SLX4 PSMB4 EME2 PSMD7 FIGNL1 PSMB5 GEN1 XRCC2 PSMB2 XRCC3 PSMB3 PSMD2 PALB2 PSMD3 SPIDR PSMB1 SLX1A;SLX1B PSMD1 CETN2 MPG ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 BAP1 UBA52 VCP-1 RPS27A UBB;UBC KPNA2 REV1 MAD2L2 REV3L MAPK8 RTEL1 PRKDC RBX1 ACD TINF2 TERF2 POT1 TERF2IP TERF1-1 PARG PNKP RAD18 POLB MBD4 SMUG1 NEIL2 APEX1 ADPRS UBE2N ASCC2 ASCC3 ZNF830 RAD51B USP10 PCLAF RAD51C USP43 SPRTN GPS1 MSH6 MSH3 TP53BP1 UVSSA POLQ RNF168-1 LIG1 LIG4 RAD52 ALKBH2 UBXN1 PPIE XRCC6 XRCC4 XRCC5 POLR2J;POLR2J2;POLR2J3 ALKBH3 ASCC1 FEN1 ELL BRIP1 CCNH WDR48 H2AC14 ISY1;ISY1-RAB43 MGMT COPS4 COPS2 PAXIP1 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B POLR2C MDC1 POLR2D POLR2G KAT5 CHEK2 SMARCA5 POLR2I CHEK1 NEIL3 NEIL1 HUS1 H2AC20 H2AB2;H2AB3;H2AB1 DCLRE1B DCLRE1A DNA2 FAAP24 RHNO1 LOC105377022;FANCB USP1 TCEA1 FAAP100 POLN CENPX SIRT6 FANCM FANCL FANCA RNF111 FANCE FANCG ATRIP FANCF UBE2T FAN1 BARD1 RAD17 ACTL6A ATM ATR BAZ1B BRCA1 H2AJ UBA7 ISG15 UBE2L6 BABAM1 BABAM2 RMI2 TRIM25 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 DDB2 APBB1 RAD51D EYA2 H2BC5 EYA3 PCNA MCRS1 EYA4 PPP5C WRN H2BC1 DCLRE1C PMS2 GTF2H1 RIF1 GTF2H3 POLL NHEJ1 GTF2H4 POLM TDP2 RPA1 HERC2 TDP1 RPA2 NPLOC4 MLH1 CDK2 UFD1 RPA3 RAD1 H2AC4 CLSPN MRE11 NBN USP7 MSH2 FANCD2 ABL1 BLM CDK7 FANCI ACTB-1 FANCC MNAT1 PIAS4 RAD51 PIAS3 FTO UBE2I ALKBH5 POLD1 PARP1 RAD9B H2BC21 EYA1 PIAS1 RAD9A SUMO1 EXO1 SUMO3 PHF6 SUMO2 H2AZ2;H2AZ1 TOPBP1 RFC5 RFC3 RFC4 TP53 RFC2 UBE2V2 GTF2H2C;GTF2H2C_2;GTF2H2 CENPS-CORT;CORT;CENPS RBBP8 OGG1 DTL RAD50 UBE2B TDG ERCC8 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 XAB2 POLR2E POLR2F PPP4R2 POLR2H TIPIN TIMELESS PPP4C POLK POLE POLR2L NFRKB RFC1 PARP2 ACTR5 USP45 H2BC15;H2BC3;H2BC11;H2BC12 LIG3 RAD23A ERCC3 CHD1L ACTR8 ERCC5;BIVM-ERCC5 RAD23B ERCC2 DDB1 INO80C ERCC6 INO80B INO80E INO80D XPA AQR COPS7B COPS7A XPC NSD2 POLD3 TFPT POLD4 PRPF19 POLD2 XRCC1 INO80 POLE4 CUL4A COPS3 COPS6 COPS5 ERCC4 POLE2 RNF4 ERCC1 RCHY1 POLE3 RUVBL1 COPS8 CUL4B SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB KANK1 GOLGA4 KDR ETV6 BIN2 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 SOS1 GABRQ GABRA1 PSENEN NEDD4 TAB2 ESR1 ADAM17 ITCH STAT5A PGR SRC PSEN1 NCSTN EGF CSN2-1 SPARC HRAS EGFR PIK3R1 MXD4 STMN1 NRAS ADAP1 CXCL12 PIK3CA NRG1 NRG2 NCOR1 EREG BTC SHC1-1 NRG3 NRG4 HBEGF WWOX UBA52 WWP1 DLG4 GABRB3 GABRB2 GABRB1 YAP1-1 RPS27A GFAP GABRG3;GABRG2 PSEN2 UBB;UBC APH1A APH1B APOE GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%888568 GABA synthesis GAD1 GAD2 GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 97%1660662 Glycosphingolipid metabolism GBA UGCG ARSD-1 ARSL B4GALT6 ARSJ ARSK ARSH B4GALT5 ARSI ST8SIA5 ARSG CTSA ST3GAL2 ST3GAL3 B3GALT4 GALC PSAP GLA M6PR B3GNT5 GAL3ST1 HEXB UGT8 GM2A HEXA GLB1L3 GLB1L2 SMPD3 B3GALNT1 GLB1L ST6GALNAC5 GLB1 SMPD2 SMPD4 ST6GALNAC6 SMPD1 ST3GAL5 ARSB ENPP7 FUT2 FUT1 CERK SUMF2 SUMF1 STS GBA2 A4GALT NEU2 ASAH1 NEU3 ASAH2 NEU1 ARSA B4GALNT1 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 97%5357801 Programmed Cell Death PDCD6IP UACA GZMH;GZMB-1 AKT2 AKT3 CHMP3 CHMP6 CHMP7 VIM OGT-1 SATB1 PSMD12 PSMD11 PSMD14 SFN RIPK3 TP63 PSMD13 DSG2 PPP3R1 MLKL PSMA7 PSMD8 GSDME PSMB6 PSMB7 PSMD6 CASP1 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 TFDP1 PSMD3 TFDP2 PSMB1 PSMD1 TP53BP2 YWHAE ADRM1 ROCK1 PSMC2-1 E2F1 PSMA2-1 PSMA5 XIAP SEM1 FLOT2 PSMA6 PSMC5 PSMA3 PSMC6 DSP PSMA4 TP73 PSMC3 PSMA1 YWHAG PSMC4 PSMC1 BIRC2 CTNNB1 BIRC3 HSP90AA1 PLEC OCLN-1 YWHAB DSG1 PTK2 AKT1 UBA52 PRKCD YWHAZ TJP1 C1QBP DAPK1-1 DAPK2 DAPK3 PKP1 SPTAN1 APPL1 DSG3 CYCS-1 RPS27A APC ADD1 UBB;UBC CDC37 CLSPN AVEN GSDMD DBNL GSN DIABLO-1 STK24 CASP9 STK26 CASP7 GAS2 BAK1 MAPT MAPK8 BCL2L11 BAD STAT3 BCL2 PMAIP1 BMF PRKN BID BBC3 BCL2L1 UNC5A PPP3CC DCC UNC5B CDH1 BCAP31 KPNB1 DNM1L BMX SDCBP CASP5;CASP4 ITCH TJP2 PPP1R13B YWHAQ YWHAH CASP6 IRF1 IRF2 APIP IL18 IL1A IL1B OPA1 APAF1 TP53 ELANE FNTA CASP3 BAX TICAM2 TRADD LY96 FASLG TRAF2 PELI1 TICAM1 KPNA1 CASP8 TNFSF10 FAS RIPK1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A CD14 FADD HMGB1-1 TLR4 CHMP4C CHMP4B PRKCQ CHMP4A LMNB1 DFFB DFFA HMGB2 PAK2 H1-0 H1-3 H1-2 H1-5 H1-4 ACIN1 FLOT1 MAGED1 CHMP2B NMT1 CHMP2A CDKN2A ARHGAP10 MAPK1 MAPK3 STUB1 OMA1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB-1 HADHA HADH ACADL ECHS1 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins LTA4H CYP1A1 CYP1A2 ALOX15 REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling CBL SOS1 PRKCA LCK PTPN6 YES1 SH2B3 SH2B2 FYN SOCS6 LYN KIT SOCS1 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-HSA-111464.5 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes APAF1 CASP3 DIABLO-1 CASP9 CASP7 CYCS-1 XIAP CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition AKT2 AKT3 CDK7 CCNA2-1 CCNA1 MNAT1 CKS1B PSMD12 PSMD11 PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 E2F4-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 TFDP1 PSMD3 RBL2 TFDP2 PSMB1 CABLES1 PSMD1 WEE1 ADRM1 MYC PSMC2-1 E2F1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 RBBP4 PSMC4 PSMC1 SKP1 MAX CCND1 LIN54 LIN37 LIN9 LIN52 AKT1 UBA52 CUL1 PTK6 CDK4 CDK2 RPS27A E2F5 UBB;UBC CCNE2 CCNE1 RB1 CCNH VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 97%180585 Vif-mediated degradation of APOBEC3G PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 RBX1 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 ELOC-1 PSMD3 PSMB1 PSMD1 ELOB ADRM1 CUL5 PSMC2-1 PSMA2-1 PSMA5 SEM1 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 97%388479 Vasopressin-like receptors AVPR1B AVPR2 OXTR AVPR1A AVP OXT-1 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid CEL LIPF CLPS PNLIP PNLIPRP1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species TXN P4HB TXN2 TXNRD1 SOD3 ATOX1 CCS AQP8 PRDX3 PRDX6 NCF1 NCF2 NOX4 NCF4 SOD2 SOD1 GSTP1 NOX5 CYCS-1 ATP7A GPX6 CAT ERO1A GPX5 GPX8 PRDX2 GPX7 PRDX1 CYBB CYBA NUDT2 TXNRD2 GPX1 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%68962 Activation of the pre-replicative complex ORC2 CDT1 CDC6 POLE PRIM2 RPA1 PRIM1 RPA2 CDC45 MCM7 POLA1 CDK2 MCM8 POLA2 MCM3 RPA3 MCM4 MCM5 MCM6 POLE4 MCM2 MCM10 DBF4 POLE2 POLE3 GMNN ORC5 ORC4 ORC6 ORC1 CDC7 ORC3 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants SOS1 PIK3CA STAT1 PIK3R2 PIK3CB STAT3 HRAS PIK3R1 PDGFRA NRAS EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.4 Expression of NOTCH2NL genes ELANE PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly ABCA1 APOC2 APOC1 MTTP APOC4 P4HB APOA2 APOB APOA1 APOA4 A2M APOC3 PRKACB-1 APOE SAR1B ZDHHC8 PRKACA-1 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-HSA-75067.4 Processing of Capped Intronless Pre-mRNA CPSF1 NCBP1 LSM10 CPSF3 LSM11 SNRPF PAPOLA SNRPB SNRPD3 SYMPK CPSF7 PABPN1-1 FIP1L1 SNRPE-2 SLBP ZNF473 CSTF3 CSTF2 NCBP2-1 CSTF2T PCF11 CPSF2-1 NUDT21 CLP1 SNRPG-2 WDR33 CPSF4 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 97%1482798 Acyl chain remodeling of CL HADHB-1 PLA2G4A TAZ HADHA LCLAT1 PLA2G6 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation UGT1A1;UGT1A6 BLVRB ALB BLVRA SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 HMOX1 ABCG2 HMOX2 FABP1 GSTA3;GSTA1 ABCC1 ABCC2 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones HSD3B1;HSD3B2 LHB AKR1B15;AKR1B10 TSPO CGA TSPOAP1 HSD17B12 STARD3 HSD17B11 STARD4 CYP21A2 STARD6 STAR CYP19A1 SERPINA6 CYP11A1 POMC STS AKR1B1 SRD5A2 FDXR SRD5A1 SRD5A3 CYP11B1;CYP11B2 HSD17B3 STARD3NL CYP17A1 HSD17B1 HSD11B1 HSD17B2 HSD11B2 FDX1 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 97%5654736 Signaling by FGFR1 FGF20 FRS2 GAB1 SOS1 PPP2R1A FGF23 PIK3CA FLRT2 PTPN11 FLRT3 FLRT1 ANOS1-1 FGF2 FGF22 FGF3 TGFBR3 FGF10 GIPC1 FGFRL1 UBA52 CBL PPP2CB;PPP2CA RPS27A SPRED2 UBB;UBC SPRED1 PLCG1 MAPK1 HRAS PIK3R1 BRAF MAPK3 FGF1 FGF6 MKNK1 FRS3 FGF4 SPRY2 NRAS FGF9 FGF18 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER ISY1;ISY1-RAB43 RBX1 CDK7 MNAT1 POLR2A POLR2B POLD1 POLR2C POLR2D POLR2G ZNF830 POLR2I RFC5 TCEA1 RFC3 RFC4 RFC2 GTF2H2C;GTF2H2C_2;GTF2H2 UVSSA ERCC8 POLR2E XAB2 POLR2F POLR2H POLK POLE POLR2L RFC1 ERCC3 PCNA UBA52 ERCC5;BIVM-ERCC5 PPIE ERCC2 DDB1 GTF2H1 GTF2H3 ERCC6 GTF2H4 RPA1 XPA RPA2 AQR POLD3 POLR2J;POLR2J2;POLR2J3 POLD4 PRPF19 POLD2 RPA3 RPS27A POLE4 CUL4A UBB;UBC ERCC4 POLE2 ERCC1 POLE3 CCNH CUL4B USP7 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants IL10RA PRF1 GCC2 GZMH;GZMB-1 RBX1 MDM2-2 STAT3 NPM1-2 STRN PRKAR1A MCL1 SEC31A MYH9 SQSTM1 IRF4 VCL RANBP2 STAT5A HIP1 BCL2A1 DCTN1 FN1 PPFIBP1 RRBP1 ALK IRS1 LMO7 TP53 PIK3R2 PIK3CB JUNB PLCG1 PIK3R1 CARS1 FRS2 HDAC1 JUN TYK2 PIK3CA PTPN6 TNRC6C MOV10 CDKN1A ATIC AGO4 AGO2 SKP1 EEF1G AGO3;AGO1 EIF2AK3 GRB2 IL22 EML4 CLTC UBA52 IL10 TPR CEBPB STAT1 MSN CUL1 KIF5B CCNB1 WDCP TPM4 BCL11A TPM3 RNF213-2 RPS27A TFG UBB;UBC ZC3HC1 FOXM1 ZAP70 KLC1 MAPK1 ICOS RB1 MAPK3 RPS6 MAPK9 FRS3 PPM1B DNMT1 MAPK8 BIRC6 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296041 Activation of G protein gated Potassium channels GNB3 KCNJ2 GNGT1 KCNJ12;KCNJ18 KCNJ3 GNB5 KCNJ4 GABBR2 GNG10 KCNJ5 GNG2 GABBR1 GNG5 KCNJ6 GNG4 KCNJ10 GNG8 KCNJ9 KCNJ15 KCNJ16 GNG13 GNB2 GNB1 GNB4 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family SLC39A10 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A4 SLC39A1 SLC39A3 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 97%5688399 Defective ABCA3 causes SMDP3 ABCA3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 97%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation HDAC1 MET LEF1 CDC25B CDKN1A CCNB1 CDK2 CTNNB1 TCF7 TCF7L2 CCND1 CDKN2A TBX2 TCF7L1 HINT1 PLK1 SIN3A ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport COG4 COG3 COG2 SPTBN2 BET1L ANK2 TGFA GOLGB1 SPTBN4 SPTBN5 CTSC TRAPPC3 TRAPPC1 GOSR2 CAPZA3 ACTR10 TRAPPC4 TRAPPC5 SAR1B TRAPPC9 ARFGAP3 GOLGA2 COG1 ARFGAP2 DCTN6 DCTN5 DCTN4 ARF4-1 SPTA1 TRAPPC2;TRAPPC2B GRIA1 TRAPPC6A NSF TMED2-1 TRAPPC6B ANK3 RAB1A RAB1B TRAPPC10 ACTR1A AREG ARF1 CSNK1D SCFD1 SPTBN1 GBF1 COL7A1 DYNC1I2 DCTN2 DCTN3 SEC24D-1 COPB1 SPTAN1 CD59 CD55 DYNC1H1 DYNC1LI1 KDELR1 DYNC1LI2 ANK1 SEC31A DYNC1I1 MIA2 MIA3 INS;INS-IGF2 CAPZB TMEM115 CTSZ DCTN1 SEC22B SEC23A CAPZA1 LMAN1 CAPZA2 SEC24B STX5 SEC24A YKT6 KDELR2 COPB2 COPA SEC24C COPE MCFD2 SERPINA1 PPP6C TMED3 PPP6R1 TMED7 PPP6R3 LMAN1L TMED9 COPZ2 GORASP1 COPZ1 SEC22A SEC22C NAPB TMED10 ARF5 STX17 LMAN2L USO1 NAPG LMAN2 SEC31B ANKRD28 SEC23IP CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 ARCN1 COPG2 FOLR1 CNIH3 COPG1 BET1 F5 F8 NAPA TFG SPTB GOSR1 ARFGAP1 TRAPPC2L COG8 TBC1D20 COG7 PREB COG6 KDELR3 COG5 SEC13 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 97%212300 PRC2 methylates histones and DNA RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 AEBP2 RBBP7 MTF2 PHF19 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 EPOP H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 H2BC5 H2BC21 H2BC1 DNMT3B H2AC20 EED H2AB2;H2AB3;H2AB1 DNMT3A EZH1 H2AZ2;H2AZ1 EZH2 PHF1 H2AC4 JARID2 DNMT1 H2AC14 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 97%375165 NCAM signaling for neurite out-growth SOS1 SPTBN2 COL4A5 SPTBN4 SPTBN5 CACNA1H CACNB2 CACNB3 GFRA1 SPTA1 GDNF COL9A1 HRAS ST8SIA4 COL9A3 COL9A2 FYN CACNA1G CACNA1I NCAN NRTN COL4A2 NCAM1 COL4A1 NRAS CACNA1S COL4A4 PRNP COL6A2 PSPN GFRA2 GFRA4 COL4A3 COL6A1 ARTN CNTN2 COL6A3 COL6A6 COL6A5 SPTBN1 PTK2 SPTAN1 ST8SIA2 CACNA1D AGRN CACNA1C PTPRA RPS6KA5 SPTB MAPK1 MAPK3 CACNB1 CACNB4 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 97%168316 Assembly of Viral Components at the Budding Site CALR-1 CANX ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296025 ATP sensitive Potassium channels ABCC8 KCNJ8 ABCC9 KCNJ11 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation CDK1 TYK2 PTPN11 DUSP5 DUSP2 DUSP1 DUSP8 DUSP9 DUSP4 IL6 MAP2K2;MAP2K1 DUSP6 DUSP7 MAPK1 JAK1 MAPK3 PEA15 JAK2 DUSP16 IL6R DUSP10 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 97%444821 Relaxin receptors RXFP4 RXFP1 RXFP2 RXFP3 RLN3 INSL3 RLN2;RLN1 INSL5 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%112382 Formation of RNA Pol II elongation complex NCBP1 EAF1 EAF2 CTR9 RTF1 CDK7 CTDP1 PAF1 MNAT1 POLR2A SUPT6H POLR2B POLR2C POLR2D AFF4 POLR2G POLR2I MLLT1 MLLT3 IWS1 SSRP1 NCBP2-1 TCEA1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNK CCNT1 CDC73 SUPT16H POLR2E LEO1 POLR2F GTF2F1 POLR2H GTF2F2 POLR2L ERCC3 ERCC2 GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 ELL ELOC-1 WDR61 ELOA NELFB ELOB CCNH NELFCD NELFA NELFE FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%75105 Fatty acyl-CoA biosynthesis ACLY SLC27A3 OLAH SLC27A2 MORC2 SCD5 ACSL1 ELOVL1 HSD17B12 ELOVL4 ACACA ELOVL2 PPT1 ELOVL3 PPT2 ELOVL6 ELOVL7 ACSBG1 SCD ACSBG2 TECR ACSF3 HACD1 HSD17B3 ACSL6 ACSL5 CBR4 HACD3 HSD17B8 TECRL HACD2 HACD4 FASN ACSL4 ELOVL5 ACSL3 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism SLC19A3 TPK1 THTPA SLC25A19 SLC19A2 ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors GRIA4 GRIA2 GRIA1 GRIA3 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends BLM CCNA2-1 CCNA1 PIAS4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I MDC1 UBE2N H2BC21 RAD9B KAT5 CHEK1 RAD9A HUS1 EXO1 SUMO2 TOPBP1 DNA2 RHNO1 RFC5 RFC3 RFC4 RFC2 SIRT6 ATRIP UBE2V2 BARD1 RBBP8 RAD17 ATM TP53BP1 RAD50 ATR BRCA1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RNF168-1 PPP4R2 TIPIN TIMELESS BABAM1 PPP4C BABAM2 RMI2 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 UBA52 WRN H2BC1 RPA1 HERC2 RPA2 CDK2 NSD2 RPA3 RPS27A RAD1 UBB;UBC CLSPN BRIP1 MRE11 RNF4 NBN EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%391903 Eicosanoid ligand-binding receptors PTGER1 TBXA2R LTB4R2 PTGDR GPR17 PTGIR CYSLTR1 PTGDR2 CYSLTR2 PTGER4 LTB4R PTGER2 PTGER3 PTGFR PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205685 PINK1-PRKN Mediated Mitophagy TBK1 UBE2V1 UBE2D3-1 PRKN OPTN-1 MAP1LC3B2;MAP1LC3B-1 SQSTM1 UBE2N UBE2D3;UBE2D2 UBA52 TOMM20 TOMM22 VDAC2-1 MAP1LC3A RPS27A MFN1 ATG9A MFN2 ATG12-1 UBB;UBC VDAC3 TOMM40 PINK1 ATG5 MTERF3 TOMM7 VDAC1 TOMM70 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 97%195399 VEGF binds to VEGFR leading to receptor dimerization FLT1 VEGFB VEGFC FLT4 VEGFD KDR VEGFA PGF DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion F9 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells EGF AREG TGFA NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME%R-HSA-9955693.1 NAGS variants cause NAGS deficiency NAGS WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 CLTB AP2A2 WNT5A ROR1 ROR2 AP2S1 FZD2 FZD5 CLTC CLTA AP2A1 AP2B1 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 97%5624958 ARL13B-mediated ciliary trafficking of INPP5E ARL13B PDE6D INPP5E DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 97%9734735 Defective ADA disrupts (deoxy)adenosine deamination ADA DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME%R-HSA-9608290.3 Defective MUTYH substrate processing DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function ABCA4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 97%381119 Unfolded Protein Response (UPR) FKBP14 HERPUD1 MYDGF YIF1A HDGF DDIT3 ERN1 CREB3 DCSTAMP MBTPS1 CREB3L3 CREB3L4 SEC31A CREB3L1 GOSR2 CREB3L2 MBTPS2 CREBRF TSPYL2 DDX11 ZBTB17 SSR1 GSK3A TLN1 DNAJC3-1 DCTN1 WFS1 TPP1 HYOU1 ASNS LMNA WIPI1 CTDSP2 NFYA-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CEBPG NFYB DNAJB9 GFPT1 NFYC CUL7 JMJD7-PLA2G4B;PLA2G4B CXXC1 CXCL8 TATDN2 PDIA6 PDIA5 KLHDC3 SRPRA EIF2S2 ATF6B HSPA5 EIF2S3;EIF2S3B CCL13;CCL2 EIF2AK3 EIF2S1 SHC1-1 ATP6V0D1 ATF6 KHSRP DNAJB11 DIS3 CEBPB ATF4 PARN EXOSC7 EXTL1 EXOSC6 ACADVL CALR-1 PPP2R5B EXOSC5 IGFBP1 ATF3 EXTL2 EXOSC4 EXOSC9 EXOSC8 SYVN1 DCP2-1 EDEM1-1 EXOSC3 ADD1 EXOSC2 EXOSC1 ARFGAP1 EXTL3 SRPRB-1 PREB HSP90B1 KDELR3 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 97%4755579 Defective SRD5A3 causes CDG-1q and KHRZ SRD5A3 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state ULK3 KIF7 DZIP1 SPOPL RBX1 SMO GPR161 NUMB SPOP KIF3A IHH CSNK1A1 PTCH1 PSMD12 PSMD11 PSMD14 PSMD13 ITCH PSMA7 PSMD8 GRK2 PSMB6 PSMB7 PSMD6 SHH PSMB4 HHIP PSMD7 BOC PSMB5 SMURF2 GAS1 PSMB2 SMURF1 ARRB2 CDON PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 CUL3 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CDC73 DHH UBA52 ARRB1 RPS27A UBB;UBC EVC2 EFCAB7 EVC GAS8 GLI1 GLI3 GLI2 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 97%4085011 Defective GNE causes sialuria, NK and IBM2 GNE NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 97%168276 NS1 Mediated Effects on Host Pathways NUP133 NUP107 NUP188 NUP50 GBP2;GBP3;GBP1 POM121;POM121C NUP54 KPNA1 NUP210 ISG15 NUP93 PABPN1-1 KPNB1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 MLKL NUP153 KPNA4-1 KPNA7 KPNA5 KPNA3 NUP35 KPNA2 EIF2AK2 NUP62 NUP37 NDC1 CPSF4 SEC13 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706574 RHOBTB GTPase Cycle DBN1 TRA2B TMOD3 COPS4 SPEN ACTN1 TXNL1 COPS2 HSP90AA1 CCT7 CPSF7 VIM TWF1 MYO6 SRRM1 DDX39B CCT6A HNRNPC RBMX HSP90AB1 MSI2 ROCK2 ACTG1 CCT2 CDC37 PHIP GPS1 RBBP6 RHOBTB1 RHOBTB2 PDE5A ROCK1 CUL3 RNF20 STK38 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) STX1A SNAP25 DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.4 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants PDGFRA TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) KCNK10 KCNK2 KCNK4 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 97%4793950 Defective MAN1B1 causes MRT15 MAN1B1 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway LIG1 PARG POLB POLE RFC1 PARP2 APEX1 ADPRS POLD1 PCNA PARP1 RPA1 RPA2 POLD3 POLD4 POLD2 RPA3 RFC5 RFC3 RFC4 POLE4 FEN1 RFC2 POLE2 POLE3 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME DATABASE ID RELEASE 97%9672396 Defective cofactor function of FVIIIa variant F8 F9 F10 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%113507 E2F-enabled inhibition of pre-replication complex formation ORC2 CDK1 CCNB1 MCM8 ORC5 ORC4 ORC6 ORC1 ORC3 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNB2 CHRNA2-1 CHRNA7;CHRFAM7A CHRNA1 CHRNB4 CHRNA9 CHRNA3 CHRNB3 CHRNA5 CHRNA4 CHRNA6 SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 97%1433557 Signaling by SCF-KIT SOS1 FER PIK3CA PTPN11 PTPN6 GRB10 PIK3R3 STAT3 GRAP2 GAB2 RAC1 YES1 GRB7 MMP9 JAK2 LYN KIT SOCS1 CBL CHEK1 STAT1 PRKCA LCK STAT5A STAT5B CMA1 FES SH2B3 PIK3R2 SH2B2 VAV1 GRAP HRAS PIK3R1 FYN SOCS6 PTPRU NRAS TEC FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome APOBEC1 APOBEC2 A1CF RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 97%442982 Ras activation upon Ca2+ influx through NMDA receptor DLG2 DLG3 DLG4 CAMK2G RASGRF1 RASGRF2 GRIN2B CALM3;CALM1 NEFL GRIN1 DLG1 LRRC7 ACTN2 HRAS CAMK2B CAMK2D GRIN2D CAMK2A NRAS REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription REST KCNIP3 SRF NR3C1 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 97%3560783 Defective B4GALT7 causes EDS, progeroid type HSPG2 BCAN VCAN GPC6 CSPG5 AGRN B4GALT7 SDC1 DCN GPC1 SDC4 GPC3 SDC2 GPC2 NCAN SDC3 GPC5 BGN GPC4 INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 97%8983432 Interleukin-15 signaling SOS1 IL15 STAT5A STAT3 STAT5B IL2RB SOS2 GAB2 GRB2 SHC1-1 IL2RG JAK1 JAK3 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.8 SUMO E3 ligases SUMOylate target proteins TRIM28 NUP133 L3MBTL2 RANGAP1 NUP50 POM121;POM121C NUP54 BMI1 SATB2 RING1 NUP42 PPARGC1A MDC1 CREBBP SATB1 NUP43 RNF2 HDAC7 RAE1 RANBP2 DAXX CBX8 NFKB2 PHC2 PHC1 CBX4 CBX2 PHC3 NUP35 IKBKE CETN2 NUP37 NCOA1 NCOA2 NCOR2 BRCA1 ING2 IKBKG SUZ12 PCNA PCGF2 WRN MITF NUP214 AURKA RPA1 HERC2 HIPK2 EP300 DNMT1 MRTFA BLM MDM2-2 NPM1-2 CDCA8 CBX5 DDX5 PIAS4 HDAC4 PIAS3 UBE2I HNRNPC THRB CHD3 VDR NR1H2 RORA NR3C1 ESR1 SIN3A PARP1 NR2C1 PIAS1 NR3C2 TRIM27 NR4A2 ZNF350;ZNF432 NR5A1 AR DNMT3B RXRA SUMO1 SUMO3 SUMO2 RARA PGR DNMT3A PPARG INCENP PPARA TP53 BIRC5 SMC5 PARK7 SMC6 SMC3 DDX17 AURKB NSMCE3 RAD21 NSMCE2 HDAC2 VHL NSMCE1 HIC1 STAG1 EID3 ZBED1 STAG2 HDAC1 TP53BP1 SMC1A PML SP3 TOP2A TOP2B MTA1 NUP107 ZNF131 NUP188 NRIP1 FOXL2 SAFB NSMCE4A TDG TOP1 SP100 NUP210 UHRF2 RNF168-1 CASP8AP2 NOP58 NUP93 MBD1 RAD52 NUP205 AAAS TFAP2C NUP160 NFKBIA NUP85 TFAP2E;TFAP2B TPR NUP88 NUP155 XRCC4 RELA NUP153 XPC CDKN2A CTBP1 EIF2AK2 TOPORS NUP62 HNRNPK NDC1 SEC13 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 97%209543 p75NTR recruits signalling complexes PRKCI TRAF6 NGF UBB;UBC MYD88 IKBKB NGFR SQSTM1 RIPK2 IRAK1 RPS27A UBA52 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPL10A RPS10 NCL-1 RPS13 RPS12 NOP56 RPL27A RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A RPLP0 TRMT112 PELP1 RPLP2 RPL36-1 RPL35A RPS27L CSNK1D RPS15A LTV1 RRP1 FTSJ3 RPS3 EBNA1BP2 ISG20L2 ERI1 LAS1L NOL12 UBA52 RBM28 RIOK2 RPS2 RIOK1 DIS3 TEX10 SENP3 GNL3 NIP7 NOL9 PES1 RIOK3 WDR18 EXOSC7 WDR12 EXOSC6 BYSL RPL18A EXOSC5 BOP1 FAU EXOSC4 TSR1 RPL12-1 MTREX EXOSC9 RPS27A EXOSC8 EXOSC3 EXOSC2 EXOSC1 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA TPTEP2-CSNK1E;CSNK1E RPL22L1 RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 RPL9 RPL6 RPL7 RPS4X SNU13 EXOSC10 RPL35 RPL38 RPS3A C1D RPP30 MPHOSPH6 RPL39 NOP2 DDX49 DDX47 RPP38 WDR3 FCF1 RPP21 RPP25 NAT10 THUMPD1 RPL21 WDR46 RPL23 WDR43 RPP14 RRP9 FBL RPL22 LOC102724159;PWP2 RPP40 BUD23 UTP14C;UTP14A UTP15 WDR36 UTP11 DIMT1 RPL24 IMP3 RPL13A-1 WDR75 RPL27 IMP4 RPL26 DDX52 RPL29 UTP18 DKC1 RPL28 DDX21 NHP2 UTP25 HEATR1 TSR3 RPL15-1 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 RPL3L RPL5-1 DCAF13 NOP58 NOP14 UTP6 UTP4 KRR1 PNO1 UTP3 RCL1 TBL3 MPHOSPH10 RPLP1-2 NOL11 NOP10 RPL23A RPL11 RPL14 XRN2 RPL13 RPL18 RPL17 RPL19 RPS15 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 97%4719377 Defective DPM2 causes CDG-1u DPM1 DPM2 DPM3 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling NGF PLCG1 NTRK1 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9768759 Regulation of NPAS4 gene expression REST KCNIP3 TNRC6C NPAS4 MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 SRF TNRC6B NR3C1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 97%71403 Citric acid cycle (TCA cycle) IDH3A CS LYRM4 CSKMT TRAP1 SDHAF2 OGDH SUCLA2 IDH3G SDHAF3 IDH2 SDHC SDHAF1 SDHD ACAT1 SDHA SDHAF4 SDHB SIRT3 NNT ISCA2 DLD ACO2 ISCA1 FH MRPS36 DLST MDH2 SUCLG2 SUCLG1 FXN IDH3B GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9840309 Glycosphingolipid biosynthesis B3GALNT1 ST6GALNAC5 ST3GAL2 ST3GAL3 B3GALT4 UGCG ST6GALNAC6 ST3GAL5 B4GALT6 B4GALT5 ST8SIA5 B3GNT5 A4GALT GAL3ST1 FUT2 FUT1 B4GALNT1 CERK UGT8 FLT3 SIGNALING BY CBL MUTANTS%REACTOME%R-HSA-9706377.2 FLT3 signaling by CBL mutants CBL FLT3LG UBB;UBC FLT3 RPS27A UBA52 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 CYP4F22 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation LYPLA1-1 ZDHHC21 DNM2 WASL NOSTRIN NOS3 NOSIP CYGB HSP90AA1 NMT1 SPR NMT2 CALM3;CALM1 CAV1 DDAH1 AKT1 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 97%6798695 Neutrophil degranulation STOM ACTR1B CTSH B2M CTSC AGPAT2 SERPINB1 ACTR10 ITGB2 PYCARD MAGT1 RAP1B ANO6 CEP290 HSPA6 EEF1A1 HSP90AA1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 EEF2 TTR RAB14 VAPA STING1 PKP1 FUCA1 VCP-1 DSC1 GSDMD TNFRSF1B DYNC1H1 TUBB4B GOLGA7-1 TUBB4A;TUBB;TUBB8B;TUBB8 DERA IST1 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E APEH CAPN1 ADAM10 HSP90AB1 ADAM8 FRK CR1L;CR1 DDOST PSEN1 C3AR1 DOCK2 HBD;HBB NCSTN ELANE PTGES2 PLAUR PLAU CTSS SERPINB6-2 MGAM MMP25 PAFAH1B2 TIMP2 CHIT1 CTSG CTSD CTSB PTPRJ MMP8 RAB7A MMP9 CNN2 CHRNB4 IDH1 ITGAL CD44 FCN2;FCN1 ANXA2 MIF CCT2 TBC1D10C PRSS3;PRSS2;PRSS1 HK3 LRRC7 RAB31 LGALS3 PDXK CCT8 ALDH3B2;ALDH3B1 TRAPPC1 RAB27A PRDX6 GDI2 B4GALT1 CAT IQGAP1 RETN PECAM1 CD36 CYB5R3 RAB6A CDK13 RAB10 RAB18 FPR1 RAC1 RHOA PGAM1 P2RX1 LAMTOR2 LAMTOR1 LAMTOR3 VNN1 DBNL GSN GPR84 FABP5 ITGAV KPNB1 COMMD9 MME TRPM2 COMMD3 APAF1 ADGRE5 FPR2 ADGRE3 CAND1 TICAM2 PADI2 CD14 CD177 PTAFR LAIR1;LAIR2-1 LYZ-1 GMFG SIGLEC9;SIGLEC7;SIGLEC8;SIGLEC12-1 MCEMP1 OSCAR HP;HPR FUCA2 PGLYRP1 CAMP OLR1 RAP1A YPEL5 DEFA6;DEFA4;DEFA5 MAPK1 TOM1 ARSA SLC11A1 ARL8A NIT2 RNASE3;RNASE2-2 ACP3 BPI S100A9 SNAP29 S100A8 SIGLEC5;SIGLEC14 LTF RNASET2 NPC2 TLR2 TMBIM1 CANT1 SELL C6orf120 CFP METTL7A-1 S100A7A;S100A7 SLPI CRISPLD2 CTSA TMEM63A SYNGR1 NBEAL2 LCN2 PSMD12 FCER1G PSMD11 CST3 PSMD14 PSMD13 RAP2B CAB39 DNAJC3-1 C1orf35 TSPAN14 PSMB7 GCA PSMD6 PSMD7 SRP14 LTA4H ENPP4 PSMD2 PSMD3 IRAG2 PSMB1 ADGRG3 PSMD1 GGH ADA2 ROCK1 MS4A3 TNFAIP6 PSMC2-1 CHI3L1 PSMA2-1 PSMA5 ATP8A1 ACAA1-1 PTX3 FRMPD3 TOLLIP DSP AHSG PLEKHO2 PSMC3 GRN ATP11B CD47 TMEM179B RAB3D ATP11A CKAP4 RAB44 LAMP1 LAMP2 KCMF1 ILF2 RAB37 RAB4B SIRPA;SIRPB1;SIRPG DSG1 FGL2 HSPA1A;HSPA1B RAB24 CPPED1 SIRPB1 KRT1 VAT1 RAB3A PRKCD CSTB SVIP C5AR1 QPCT ATP6V1D COTL1 COPB1 GSTP1 ATP6V0A1 CYFIP1 ATP8B4 CLEC12A TMEM30A SCAMP1 CD59 SERPINB3;SERPINB4-1 ITGAM CD55 PIGR HSPA8 TMC6 SERPINB10 MAPK14 SERPINB12 PKM TCIRG1 LRG1 OLFM4 PTPRB PRCP DYNC1LI1 ACLY PNP-1 VPS35L ATP6V0C SLC27A2 SURF4 IQGAP2 PRG2 PRG3 ORM2;ORM1 TYROBP QSOX1 CD53 CD63 PGRMC1 NCKAP1L CREG1 CD68 JUP MPO OSTF1 CD93 DOK3 SDCBP ARHGAP9 CTSZ TARM1 ANPEP MVP PDAP1 S100P ABCA13 HPSE ATP6AP2 NHLRC3 UNC13D SNAP25 A1BG CRACR2A PRDX4 S100A11 PA2G4 SERPINA3 ALAD PGM2 FGR NFAM1 AGA PGM1 ERP44 FCGR3A;FCGR3B SLCO4C1 GHDC EPX NRAS CLEC4D S100A12 BRI3 HVCN1 CFD C3-1 KCNAB2 SERPINA1 PTPRN2 STK11IP BST2 HMGB1-1 DNASE1L1 ATAD3A;ATAD3B DPP7 DNAJC13 CRISP3 HEBP2 CMTM6 MLEC PPIE FTH1 XRCC6 XRCC5 STK10 VAMP8 PTPRC RAB5C ASAH1 NEU1 NFASC TXNDC5 AP1M1 FTL-1 AOC1 IGF2R ARPC5 BST1 RAB5B SNAP23 CD33-1 CAP1 GYG1 ACTR2 GAA APRT AGL-1 PSAP ORMDL3 HEXB GM2A GLB1 GUSB ARSB HGSNAT CXCL2;CXCL3;CXCL1-1 PFKL CXCR1 IMPDH1 DSN1 IMPDH2 CXCR2 FAF2 ITGAX AP2A2 PPBP STBD1 SPTAN1 RHOG RHOF ATG7 DEGS1 MGST1 NDUFC2;NDUFC2-KCTD14 HUWE1 PLAC8 GLIPR1 VCL RAB9B DYNLT1 MANBA GALNS NME2 AMPD3 GLA CDA PPIA ARG1 ARMC8 ALDOC CYBB CYBA ALDOA ARHGAP45 BIN2 CPNE3 UBR4 GNS PTPN6 DGAT1 DDX3X-1 DNAJC5 HMOX2 CSNK2B CLEC5A TCN1 ALOX5 DIAPH1 PYGB PLD1 GPI PYGL MAN2B1 NFKB1 SLC44A2 LPCAT1 NAPRT SLC15A4 SLC2A5 MOSPD2 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion PLCB1 PLCB2 GNA14 FFAR1 GNA15 GNAQ GNA11 PLCB3 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint CDK1 BUB1B CDC20 CCNA2-1 CCNA1 BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NEK2 PSMC3 PSMA1 PSMC4 PSMC1 UBA52 ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 RPS27A UBE2C UBE2E1 UBB;UBC UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 97%5683371 Defective ABCB6 causes MCOPCB7 ABCB6 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 97%5654227 Phospholipase C-mediated cascade; FGFR3 FGF20 FGF23 PLCG1 FGF1 FGF4 FGF16 FGF9 FGF2 FGF18 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants KIT GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly GJA1 GJC1 GJB2 GJC2 GJB1 GJA3 GJA10 GJA5 GJA4 GJA9 GJA8 GJD2 GJD4 GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702998.2 linifanib-resistant FLT3 mutants FLT3 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 97%1606341 IRF3 mediated activation of type 1 IFN TBK1 NLRP4 ZBP1 IRF3 DTX4 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus CNTN1 MIB2 DLL1 JAG2 PSEN1 DLL4 RPS27A PSENEN NCSTN NEURL1 PSEN2 UBB;UBC NEURL1B APH1A APH1B MIB1 NOTCH2 MDK JAG1 UBA52 ADAM10 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME DATABASE ID RELEASE 97%5619071 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662361 Sensory processing of sound by outer hair cells of the cochlea KCNMB1 KCNMA1 MYH9 EPB41L1 RIPOR2 CLIC5 CIB2 PJVK EPS8 TPRN PLS1 TMC1 ESPN-1 MYO7A TMC2 MYO3B MYO3A KCNQ4 FSCN2 MYO1C EZR PCDH15 USH1C TWF1 ESPNL CDH23 OTOG CASK SPTBN1 CHRNA9 CHRNA10 XIRP2 KCNN2 EPS8L2 MPP1 GRXCR1 GRXCR2 WHRN RDX LHFPL5 OTOGL MSN TMIE USH1G STRC MYO15A SLC26A5 SPTAN1 GSN B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%5250924 B-WICH complex positively regulates rRNA expression DDX21 TAF1D BAZ1B TAF1B TAF1C KAT2B H2AJ TAF1A KAT2A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E ACTB-1 POLR2F POLR2H GSK3B POLR2L H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 DEK SF3B1 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 SMARCA5 ERCC6 MYBBP1A H2AC20 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EP300 POLR1A POLR1B POLR1C H2AC4 POLR1D POLR1E POLR1F POLR1G POLR1H H2AC14 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function ATM RAD50 BLM BRCA1 RMI2 RAD51 RMI1 TOP3A RAD51D WRN KAT5 RAD51B RAD51C EXO1 BRCA2 RAD51AP1 DNA2 XRCC2 PALB2 BRIP1 MRE11 NBN BARD1 RBBP8 SEM1 MACROAUTOPHAGY%REACTOME%R-HSA-1632852.12 Macroautophagy TBK1 ULK1 GABARAP CHMP3 CSNK2A1;CSNK2A3 CHMP6 CHMP7 MAP1LC3B2;MAP1LC3B-1 ATG14 PRKAB2 PIK3R4 HDAC6 PRKAB1 RRAGA RRAGC RRAGB MTMR3 CETN1 TOMM20 RRAGD TOMM22 VDAC2-1 MAP1LC3A FUNDC1 ATG9A ATG12-1 ARL13B VDAC3 WIPI1 TOMM40 ATG5 MTERF3 TOMM7 TOMM70 MTMR14 PRKAG2 ATM UBE2D3-1 PRKAG1 HSF1 PRKAG3 HSP90AA1 RPTOR OPTN-1 CFTR PLIN2 UBA52 EPAS1 TSC2 TSC1 DYNC1I2 ATG3 ATG9B ATG10 ATG13 VCP-1 ATG101 RPS27A PCNT ATG16L2 LAMTOR2 ATG16L1 LAMTOR1 WDR45 UBB;UBC LAMTOR4 MAP1LC3C LAMTOR3 HSPA8 RB1CC1 LAMTOR5 WIPI2 VDAC1 ATG4C DYNC1H1 ATG7 ATG4B ATG4A ATG4D WDR45B AMBRA1 DYNC1LI1 DYNC1LI2 UBE2V1 IFT88 SLC38A9 PRKN DYNC1I1 UVRAG NBR1 RHEB PEX5 USP30 SQSTM1 UBE2N MLST8 MFN1 MFN2 PIK3C3 BECN1 PARK7 PRKAA1 MTOR CSNK2A2 PRKAA2 CSNK2B CHMP4C CHMP4B CHMP4A UBE2D3;UBE2D2 PLIN3 CHMP2B CHMP2A PINK1 GABARAPL2 REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA SLC6A13 SLC6A1 SLC6A12 SLC6A11 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-HSA-9609736.5 Assembly and cell surface presentation of NMDA receptors KIF17 CAMK2G GRIN2A GRIN2B GRIN1 APBA1 ACTN2 CASK LIN7A LIN7C GRIN2C GRIN2D GRIN3B GRIN3A DLG2 DLG3 DLG4 NBEA NEFL DLG1 LRRC7 LIN7B CAMK2B CAMK2D CAMK2A REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.2 Regulation of MECP2 expression and activity HDAC1 CAMK2G LBR TNRC6C FOXG1 MOV10 TNRC6A-1 AGO4 AGO2 NCOR2 AGO3;AGO1 TNRC6B NCOR1 CALM3;CALM1 GPS2 SIN3A HTT CAMK4 HIPK2 TBL1XR1 CAMK2B AURKB CAMK2D HDAC2 CAMK2A HDAC3 PRKACA-1 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME%R-HSA-9686114.3 Activation of inflammatory caspases CALM3;CALM1 SERPINB1 GSDMD CASP3 IL18 CASP5;CASP4 IL1B DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-HSA-174113.5 SCF-beta-TrCP mediated degradation of Emi1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CDC20 FBXO5 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 PSMA7 PSMD8 FZR1 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717319 brigatinib-resistant ALK mutants ALK ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428643 Organic anion transport by SLC5 17 25 transporters SLC25A11 SLC25A1 SLC17A5 SLC5A12 SLC5A8 SLC25A10 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System S100A8 TLR2 MYD88 TLR3 LY96 IRAK4 CHUK TICAM1 BTK TLR7 CD14 HMGB1-1 TIRAP TLR4 IKBKB IKBKG FGB FGA NFKBIA UNC93B1 FGG F2 RELA TLR10 NFKB2 SERPING1 F12 TRAF3 TLR6 S100A1 TLR5 NFKB1 KLKB1 CD36 TLR1 S100A9 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8939902 Regulation of RUNX2 expression and activity RBX1 HIVEP3 GSK3B PPARGC1A PPARGC1B NR3C1 ESR1 PSMD12 MSX2 PSMD11 PSMD14 PSMD13 PSMA7 BMP2 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 ESRRA PSMD7 PSMB5 PSMB2 SMURF1 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 DLX6 CBFB DLX5 UBA52 WWP1 NKX3-2 STAT1 CUL1 RPS27A UBB;UBC STUB1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2500257 Resolution of Sister Chromatid Cohesion NUP133 NDC80 BUB1 RANGAP1 CLASP2 BUB1B CDC20 PPP1CC BUB3 MAD2L1 SPDL1 NUP43 RANBP2 C1orf112 NSL1 RPS27 NUP37 MAPRE1-1 PPP2R1A KNL1 ZW10 CDCA5 PDS5B PDS5A WAPL DSN1 CKAP5 RCC2 ZWINT XPO1 AHCTF1 PAFAH1B1 DYNC1I2 CCNB2 CCNB1 PPP2CB;PPP2CA PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B CLASP1 PPP2R5E DYNC1H1 NDE1 PLK1 CDK1 DYNC1LI1 DYNC1LI2 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 DYNC1I1 B9D2 SPC24 SPC25 ERCC6L NUF2 KIF2A ZWILCH NUDC KIF2C PMF1;PMF1-BGLAP KIF2B INCENP KNTC1 CENPA BIRC5 CENPE CENPC SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A CENPT NUP107 CENPU CENPF CENPH CENPI TAOK1 CENPK CENPL CENPM CENPO NUP160 CENPP NUP85 CENPQ CLIP1 MAD1L1 ITGB3BP SEC13 AZATHIOPRINE ADME%REACTOME%R-HSA-9748787.3 Azathioprine ADME HPRT1 GUK1 ABCC5 NME2 GMPS ABCC4 RAC1 TPMT VAV3 NME1 SLC28A2 SLC29A1 GSTA3;GSTA5;GSTA1;GSTA2 VAV1 IMPDH1 VAV2 IMPDH2 SLC29A2 SLC28A3 GSTM1;GSTM2-1 XDH GSTA3;GSTA1 NUDT15 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins FIP1L1 STRN WDR48 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 97%2555396 Mitotic Metaphase and Anaphase BUB1 CLASP2 BUB1B CDC20 FBXO5 PPP1CC BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 RPS27 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 MAPRE1-1 PSMA5 SEM1 PSMA6 TUBA1A PSMC5 PPP2R1A PSMA3 LBR PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 LEMD3 CKAP5 TUBA4A XPO1 UBA52 PAFAH1B1 TNPO1 DYNC1I2 CCNB2 CCNB1 ANKLE2 RPS27A CLASP1 UBB;UBC DYNC1H1 NDE1 PLK1 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 CDK1 DYNC1LI1 DYNC1LI2 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 IST1 SPAST CC2D1B NUF2 KIF2A EMD NUDC KIF2C KIF2B INCENP CENPA CENPE CENPC CENPT NUP107 CENPU NUP188 RCC1 BANF1 CENPF CENPH CENPI NUP93 TAOK1 CHMP4C CENPK CHMP4B CHMP4A LMNB1 CENPL NUP205 CENPM CENPO PPP2R2A;PPP2R2D CENPP NUP160 NUP85 CENPQ TUBA1C TUBB1 NUP155 CHMP2B CHMP2A TUBB2B;TUBB2A CLIP1 MAD1L1 NUP62 NDC1 SEC13 TUBB3;TUBB6 TUBAL3 NUP133 NDC80 RANGAP1 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 TUBA3E;TUBA3C-1 VPS4A SPDL1 NUP43 RANBP2 TUBA8 NSL1 NUP35 RAN NUP37 KNL1 ZW10 CDCA5 PDS5B PDS5A WAPL ESPL1 DSN1 RCC2 ZWINT AHCTF1 PPP2CB;PPP2CA PTTG1;PTTG2 PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E VRK1 LEMD2 DYNC1I1 KPNB1 UBE2I B9D2 SPC24 SPC25 ERCC6L SUMO1 ZWILCH SIRT2 PMF1;PMF1-BGLAP KNTC1 BIRC5 SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-HSA-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA DLD DLST DHTKD1 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 97%380994 ATF4 activates genes in response to endoplasmic reticulum stress HERPUD1 CXCL8 DDIT3 CCL13;CCL2 ATF6 KHSRP DIS3 CEBPB ATF4 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 IGFBP1 ATF3 EXOSC9 EXOSC8 DCP2-1 ASNS EXOSC3 EXOSC2 EXOSC1 NFYA-1 CEBPG NFYB NFYC UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%438066 Unblocking of NMDA receptors, glutamate binding and activation DLG2 DLG3 DLG4 CAMK2G GRIA2 GRIA1 GRIN2A GRIA3 GRIA4 GRIN2B CALM3;CALM1 NEFL GRIN1 DLG1 LRRC7 ACTN2 CAMK2B GRIN2C CAMK2D GRIN2D CAMK2A DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 97%4687000 Defective MPDU1 causes CDG-1f MPDU1 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.4 Breakdown of the nuclear lamina LMNB1 CASP6 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1B AVPR1A AVP IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IKBKB IKBKG CHUK CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 97%5621575 CD209 (DC-SIGN) signaling CLEC4M;CD209-2 RELA PAK1 EP300 RELB PAK3 RPS6KA5 NFKB1 RAF1 HRAS FYN PRKACB-1 CREBBP LYN ICAM2 ICAM3 NRAS PAK2 PRKACA-1 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane RHOQ AKT2 RALGAPA2 RALGAPB C2CD5 SNAP23 STXBP3 STX4 PRKAB2 TBC1D1 MYH9 KIF3A TBC1D4 SFN YWHAQ PRKAB1 YWHAH RAB4A YWHAE PRKAG2 RAB10 RAB13 PRKAA2 YWHAG EXOC8 PRKAG1 RAB8A EXOC7 RAC1 PRKAG3 MYO5A MYO1C EXOC4 EXOC3 EXOC6 CALM3;CALM1 EXOC5 EXOC2 EXOC1 YWHAB RAB14 AKT1 RAB11A VAMP2 YWHAZ SLC2A4 RALA-1 KIFAP3 LNPEP KIF3B TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9679504.6 Translation of Replicase and Assembly of the Replication Transcription Complex CHMP3 CHMP2B CHMP6 CHMP7 CHMP2A MAP1LC3B2;MAP1LC3B-1 PIK3C3 CHMP4C CHMP4B BECN1 UVRAG CHMP4A PIK3R4 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants SOS1 PIK3CA STAT1 PIK3R2 PIK3CB STAT3 HRAS PIK3R1 PDGFRA NRAS BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins LTA4H ALOX5 ALOX15 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 97%176187 Activation of ATR in response to replication stress ORC2 RAD17 CDC6 ATR RAD9B CHEK1 RAD9A CDC25A RPA1 HUS1 RPA2 CDC45 MCM7 CDK2 MCM8 MCM3 RPA3 MCM4 RFC5 MCM5 RFC3 RAD1 MCM6 RFC4 MCM2 RFC2 CLSPN MCM10 DBF4 ATRIP ORC5 ORC4 ORC6 ORC1 CDC7 ORC3 CDC25C TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors HSPD1 CDKN1A TGFA NPM1-2 CGA KDM5B YY1 UBE2I DEK VEGFA TFAP2A WWOX CREBBP CITED1 TFAP2C KIT CITED2 TFAP2D CITED4 KCTD1 ESR1 TFAP2E;TFAP2B KCTD15 SUMO1 ATAD2 MYBL2 NOP2 EP300 ERBB2 YEATS4 EGFR APOE MYC PITX2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-HSA-75953.4 RNA Polymerase II Transcription Initiation GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.5 DNA Damage Telomere Stress Induced Senescence ATM RAD50 CDKN1A CDKN1B ACD HIRA EP400 TINF2 H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCNA2-1 POT1 HMGA2 CCNA1 TERF2IP TERF1-1 CABIN1 LMNB1 ASF1A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC21 H2BC1 KAT5 UBN1 H1-0 H1-3 H1-2 H1-5 H1-4 H2AC20 CDK2 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 TP53 MRE11 CCNE2 CCNE1 RB1 NBN H2AC14 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair CCNA2-1 CCNA1 PAXIP1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MDC1 KDM4A PSMD12 KDM4B KAT5 POLH CHEK2 PSMD11 SMARCA5 CHEK1 PSMD14 PSMD13 HUS1 PSMA7 MUS81 PSMD8 C1orf112 EME1-1 BRCA2 PSMB6 DNA2 RAD51AP1 PSMB7 PSMD6 RHNO1 SLX4 EME2 PSMB4 PSMD7 FIGNL1 GEN1 PSMB5 XRCC2 PSMB2 XRCC3 SIRT6 PSMB3 PSMD2 PALB2 PSMD3 SPIDR PSMB1 SLX1A;SLX1B PSMD1 ATRIP ADRM1 BARD1 PSMC2-1 PSMA2-1 PSMA5 SEM1 RAD17 PSMA6 ATM PSMC5 PSMA3 PSMC6 ATR PSMA4 BAZ1B PSMC3 PSMA1 PSMC4 PSMC1 BRCA1 BABAM1 BABAM2 RMI2 UIMC1 RMI1 ABRAXAS1 TOP3A RNF8 BRCC3 APBB1 RAD51D EYA2 H2BC5 EYA3 BAP1 PCNA EYA4 UBA52 PPP5C WRN H2BC1 DCLRE1C RIF1 POLL NHEJ1 POLM TDP2 RPA1 HERC2 TDP1 RPA2 CDK2 RPA3 RPS27A RAD1 KPNA2 UBB;UBC CLSPN MRE11 NBN MAPK8 RTEL1 ABL1 BLM PRKDC RBX1 PIAS4 RAD51 UBE2I POLD1 UBE2N RAD9B H2BC21 PARP1 EYA1 RAD9A RAD51B RAD51C SUMO1 EXO1 PHF6 SUMO2 TOPBP1 RFC5 RFC3 RFC4 TP53 RFC2 UBE2V2 RBBP8 TP53BP1 RAD50 POLQ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 LIG1 RNF168-1 LIG4 PPP4R2 TIPIN TIMELESS PPP4C POLK RAD52 POLE RFC1 UBXN1 PARP2 H2BC15;H2BC3;H2BC11;H2BC12 LIG3 DDB1 XRCC6 XRCC4 XRCC5 NSD2 POLD3 POLD4 POLD2 XRCC1 POLE4 CUL4A FEN1 BRIP1 ERCC4 POLE2 RNF4 ERCC1 POLE3 CUL4B NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%181430 Norepinephrine Neurotransmitter Release Cycle UNC13B MAOA RAB3A SYT1 VAMP2 STX1A CPLX1 SNAP25 RIMS1 PPFIA1 PPFIA4 SLC22A2 SLC18A2 SLC22A1 PPFIA3 PPFIA2 TSPOAP1 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling GNAS-1 ADCY9 PRKAR2B PRKAR1B PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A PRKACA-1 PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 97%176412 Phosphorylation of the APC C CDK1 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CCNB1 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 PLK1 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells TET2 CBFA2T2 CXCR4 PRDM1 BMP4 POU5F1;POU5F1B NANOS3 EOMES TFAP2C NANOG;NANOGP8 PDPN SOX17 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-HSA-1236978.5 Cross-presentation of soluble exogenous antigens (endosomes) PSMA6 MRC1 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSME2 PSMB4 PSMD7 PSMB5 MRC2 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSME1 PSMD1 PSMB10 PSMB8 FCGR1A ADRM1 PSMB9 CD207 PSMC2-1 PSMA2-1 PSMA5 SEM1 PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism UGT1A1;UGT1A6 BLVRB BLVRA COX15 ALAS2 HMOX1 ALAS1 CPOX HMOX2 ALAD ALB COX10 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 UROS PPOX ABCG2 UROD HMBS FECH FABP1 GSTA3;GSTA1 ABCC1 ABCC2 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 97%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) DPF1 DPF2 DPF3 SMARCC1 SMARCC2 ACTB-1 PIWIL4 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CHD3 DNMT3L BCL7A SS18L1 H2BC21 BCL7C BCL7B SMARCA2 SMARCA4 H2AC20 H2AB2;H2AB3;H2AB1 DNMT3A H2AZ2;H2AZ1 ARID1A ARID1B C19orf84 SMARCD1 SMARCD2 SS18 HDAC2 SMARCD3 ACTL6A HDAC1 MTA1 RBBP4 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 MTA2 MTA3 SMARCE1 MBD3 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 GATAD2B GATAD2A H2AC4 SPOCD1 SMARCB1 H2AC14 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair ISY1;ISY1-RAB43 COPS4 COPS2 YY1 POLR2A POLR2B POLR2C POLR2D POLR2G POLR2I TCEA1 RNF111 CETN2 ACTL6A DDB2 PCNA MCRS1 UBA52 GTF2H1 GTF2H3 GTF2H4 RPA1 RPA2 RPA3 RPS27A UBB;UBC USP7 RBX1 CDK7 ACTB-1 MNAT1 PIAS3 UBE2I POLD1 UBE2N PARP1 PIAS1 ZNF830 SUMO1 SUMO3 SUMO2 RFC5 RFC3 RFC4 RFC2 GPS1 UBE2V2 GTF2H2C;GTF2H2C_2;GTF2H2 UVSSA ERCC8 POLR2E XAB2 LIG1 POLR2F POLR2H POLK POLE POLR2L NFRKB RFC1 PARP2 ACTR5 USP45 LIG3 RAD23A ERCC3 CHD1L ACTR8 PPIE ERCC5;BIVM-ERCC5 RAD23B ERCC2 DDB1 INO80C ERCC6 INO80B INO80E INO80D XPA AQR COPS7B COPS7A XPC POLD3 POLR2J;POLR2J2;POLR2J3 TFPT POLD4 PRPF19 POLD2 XRCC1 INO80 POLE4 CUL4A COPS3 COPS6 ELL COPS5 ERCC4 POLE2 ERCC1 POLE3 RUVBL1 COPS8 CCNH CUL4B FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190241 FGFR2 ligand binding and activation FGF20 FGF23 FGF2 FGF7 FGFBP1 FGFBP3 FGF22 FGF3 FGF10 FGF1 FGF6 FGF4 FGF16 FGF9 FGF18 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription STAT3 WWTR1 DPY30 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP H2BC21 LEF1 WDR5 H2AC20 IRF1 NFKB2 EED H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EZH2 ASH2L HIF1A MYC JUND MYCN JUN NFE2L2 RBBP4 TEAD1 TEAD2 RBBP5 BRD4 TEAD3 CTNNB1 H2AJ FOSB TEAD4 TCF7 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TCF7L1 FOS H2BC15;H2BC3;H2BC11;H2BC12 SUZ12 H2BC5 EPAS1 H2BC1 STAT1 RELA YAP1-1 ATF3 EP300 TCF7L2 H2AC4 NFKB1 KMT2A KMT2C H2AC14 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation GP1BA GP5 GP9 F9 GP1BB F11 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling GPER1 ITGB1 GNG10 GNAS-1 GNG2 GNG5 ADCY9 GNG4 PRKAR1B GNG8 PRKAR1A ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 PRKACB-1 GNB2 PRKAR2A GNB1 GNB4 GNB3 GNGT1 GNB5 PRKAR2B ITGA5 SRC GNAT3 GNAI1 GNAZ GNAI3 GNAI2 PRKACA-1 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%5656169 Termination of translesion DNA synthesis UBA7 ISG15 UBE2L6 POLK POLE TRIM25 RFC1 POLD1 PCNA UBA52 POLI POLH USP10 PCLAF USP43 RPA1 RPA2 POLD3 POLD4 POLD2 RPA3 RPS27A RFC5 RFC3 RFC4 POLE4 UBB;UBC RFC2 REV1 POLE2 POLE3 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) PIGL DPM2 PIGG PIGF PIGH PIGO PIGN PIGP PIGZ PIGW PIGV PIGC PIGB PIGX-1 PIGA PIGM TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 97%168271 Transport of Ribonucleoproteins into the Host Nucleus NUP133 NUP107 NUP188 NUP50 POM121;POM121C NUP54 KPNA1 NUP210 NUP93 KPNB1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 NUP155 NUP153 NUP35 NUP62 NUP37 NDC1 SEC13 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 HSPG2 GPC6 EXT1 EXT2 AGRN SDC1 GPC1 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 GPC4 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release ATM TP63 PPP1R13B BAX TP73 PMAIP1 BID BBC3 ZNF420 AIFM2 TP53 STEAP3 TP53BP2 PRELID3A BNIP3L CREBBP PRELID1 TP53INP1 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696394 DNA Damage Recognition in GG-NER ACTL6A RBX1 COPS4 COPS2 ACTB-1 YY1 NFRKB PARP2 ACTR5 DDB2 RAD23A MCRS1 ACTR8 UBA52 PARP1 RAD23B DDB1 INO80C INO80B INO80E INO80D COPS7B COPS7A XPC TFPT RPS27A INO80 CUL4A UBB;UBC COPS3 COPS6 GPS1 COPS5 CETN2 RUVBL1 COPS8 CUL4B METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 97%8953854 Metabolism of RNA RPS14 RPS17 TRA2B RPS16 SNRPD2 RPS19 SNRPD1 RPS18 SNRPD3 RPS11 RPL10A RPS10 RPS13 RPS12 SNRPE-2 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 MTERF3 RPL36AL-1 PTBP1 PPP1CB HNRNPH1 HNRNPA1-1 HNRNPM PPP2R1A SUPV3L1 PNPT1 SLIRP REXO2 LRPPRC SMN2;SMN1 RPS27L CSNK1D RPS15A LTV1 RRP1 RPS3 FTSJ3 EBNA1BP2 ISG20L2 ERI1 LAS1L NOL12 UBA52 RBM28 RIOK2 RPS2 RIOK1 TEX10 SENP3 GNL3 NIP7 NOL9 PES1 RIOK3 WDR18 WDR12 BYSL RPL18A BOP1 FAU TSR1 RPS27A GEMIN2 UBB;UBC RPS9 RPS7 RPS8 RPS5 RPS6 RPSA ZCRB1 GEMIN4 TPTEP2-CSNK1E;CSNK1E GEMIN5 GEMIN6 SNRPF GEMIN7 GEMIN8 SNRPB DDX5 TCERG1 GPATCH1 PNN METTL3 CXorf56-1 FASTKD2 ZNF830 FASTKD5 SF1 TBRG4 SLBP ZNF473 DHX8 PRKRIP1 CWF19L2 RPS4X SNU13 RNPC3 HTATSF1 WDR70 RPS3A DHX35 PRPF38A SMU1 PPP1R10 DDX49 NKAP DDX47 UBL5 WDR3 FCF1 PRPF40A GCFC2 NAT10 THUMPD1 PRPF18 WDR46 SDE2 WDR43 TUT1 RRP9 FAM32A CACTIN FBL SRSF10 LOC102724159;PWP2 SRSF12 BUD23 DDX20 PRPF31 UTP14C;UTP14A PDCD7 UTP15 WDR36 EIF4A2 RBMX2 PAPOLG UTP11 SNRPG-2 EIF4A1 SNIP1 DIMT1 TUT7 SNRNP35 IMP3 WDR75 TUT4 IK PRPF4B IMP4 LENG1 DDX52 PRPF4 UTP18 DKC1 PRPF3 NHP2 SNRNP27 SNRNP25 UTP25 SNRPC HEATR1 TSR3 SNRPA NOC4L RPL15-1 PPP1R8;STX12 NOL6 ZMAT2 RRP7A ZMAT5 CCDC12 EMG1 YJU2 EIF4E PDCD11 LSM5 EIF4B BMS1 PAIP1 LSM4 DHX37 RRP36 LSM3 LSM2 UTP20 LSM8 DCAF13 NOP14 LSM7 UTP6 LSM6 UTP4 PABPN1-1 RBM25 KRR1 NSRP1-1 PNO1 PPWD1 UTP3 DDX41 RCL1 USP39 TBL3 SART1 METTL14 MPHOSPH10 SNRNP70 NOL11 NOP10 TFIP11 SYF2 PPP2R2A;PPP2R2D LUC7L3 C9orf78 WBP4 ZRSR2-1 RNF113A RBM39 PPIL2 WTAP MFAP1 ACIN1 RBM42 BUD13 HNRNPF SNRNP48 HNRNPA2B1 FAM50A SNRPA1 MTERF4 NSUN4 RPUSD4 RPUSD3 TRUB2 RCC1L NGRN MRM2 MRM3 XRN2 CCNH HBS1L TTC37 NT5C3B DCPS WDR82 NOP56 TP53RK SKIV2L RPL10;RPL10L-1 SNW1 RPLP0 TRMT112 PELP1 RPLP2 RPL36-1 TNKS1BP1 PRMT5 CNOT6L SF3B1 GTF2H1 GTF2H3 GTF2H4 MTREX DDX6 LSM1 PATL1 ZCCHC8 EDC3 EDC4 DCP1B TYW5 TYW1;TYW1B TRMT5 TYW3 TRMT12 LCMT2 NXT1 U2AF1L5;U2AF1 EIF4A3 RPL22L1 CASC3 GLE1 NXF2;NXF2B;NXF5-1 THOC1 THOC3 CDK7 THOC2 THOC5 CDC40 CNOT10 RPL37A-1 THOC7 THOC6 CNOT4 MNAT1 CNOT6 SRRM1 DDX39A DDX39B SARNP CNOT7 ZC3H11A SRSF2 CNOT11 SRSF3 SRSF5 CNOT1 SRSF6 CNOT2 SLU7 SRSF7 CNOT3 SRSF9 RBM8A RBM27 ZCCHC7 POLDIP3 CNOT8 SRSF1 RBM26 CNOT9 YTHDC1 NXF1 ZC3H4 U2AF2 FYTTD1-1 ZC3H3 DHX38 YTHDC2 SRSF11 TENT4B EXOSC10 MAGOH;MAGOHB RBM7 SRSF4-1 ZC3H18 CHTOP ZFC3H1 C1D ALYREF UPF3B DXO RNPS1 MPHOSPH6 NOP2 YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 RPL13A-1 DDX21 WDR77 POLR2E SAP18 POLR2F POLR2H TRMT10C PRORP POLR2L TRNT1 HSD17B10 ERCC3 ERCC2 RPL23A GSPT2 GSPT1 UPF2 ETF1 RPL27A PSMD12 PSMD11 PSMD14 PSMD13 GRSF1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PPP1CA PSMC3 PSMA1 PSMC4 PSMC1 YWHAB HSPA1A;HSPA1B HSPB1 RBMX ELAVL1 ZFP36 XPO1 KHSRP AKT1 TNPO1 NUP214 DIS3 PRKCD PRKCA YWHAZ XRN1 MAPKAPK2 PARN ZFP36L1 EXOSC7 EXOSC6 IGF2BP3 EXOSC5 IGF2BP2 EXOSC4 RPL12-1 SET-1 EXOSC9 EXOSC8 DCP2-1 EXOSC3 EXOSC2 EXOSC1 HSPA8 PABPC1;PABPC3 MAPK14 ANP32A;ANP32D MAPK11 DCP1A EIF4G1 RAMAC LSM10 LSM11 RPL26L1 RPL4 RPL30 MTPAP RPL3 PHAX RPL32 RPL31 HNRNPC RPL34 RPL8 RPL9 RPL6 RPL7 POP5 POP7 POP1 RPL35 TSEN15 POP4 RPL38 RPP30 RTCB ZBTB8OS RPL39 TSEN2 TSEN54 CPSF2-1 RPP38 RPP21 RPP25 TSEN34 RPL21 DDX1 RPL23 RPP14 NUDT21 C2orf49 RPL22 RTRAF RPP40 XPOT FAM98B FUS RPL24 RPL27 BCAS2 RPL26 RPL29 RPL28 HNRNPA3 GPKOW YRDC CDC5L NUP107 TRMU OSGEPL1 NUP188 MTO1 TRMT61B GTPBP3 NUP210 DHX9 RPL3L GTF2F1 NOP58 GTF2F2 NUP93 SUGP1 NUP205 RPLP1-2 AAAS NUP160 NUP85 PPIE TPR PPIH NUP88 PPIG NUP155 TENT4A NUP153 SUPT5H POLR2J;POLR2J2;POLR2J3 HNRNPU HNRNPR WDR61 RPL11 NUP62 RPL14 HNRNPL HNRNPK RPL13 HNRNPD RPL18 RPL17 RPL19 WDR33 NDC1 SEC13 ISY1;ISY1-RAB43 NCBP1 NUP133 PHF5A PAPOLA TXNL4A URM1 NUP50 SNRPN WDR4 POM121;POM121C THADA LAGE3 EPRS1 NUP54 OSGEP THG1L ALKBH8 NCL-1 TRMT44 C9orf64 TRDMT1 RNMT PLRG1 PUS3 TRMT10A DNAJC8 METTL1 NSUN2 TPRKB ADAT1 POLR2A FIP1L1 TRMT1 NUP42 NSUN6 POLR2B POLR2C SNRNP40 CDKAL1 PUS7 FTSJ1 POLR2D PPIL3 ADAT3 PPIL4 TRIT1 NUP43 ADAT2 POLR2G SRRM2 QTRT1 TRMT9B POLR2I CRNKL1 DUS2 RAE1 QTRT2 RANBP2 CTU2 CTU1 TRMT6 RNGTT CSTF3 CSTF2 TRMT13 CLNS1A TRMT11 SNUPN TRMT61A NCBP2-1 HNRNPH2 NUP35 RBBP6 CWC25 RAN PPIL1-1 CWC27 CWC22 NUP37 RPL7A PRPF6 PRPF8 CPSF4 CPSF1 CPSF3 CWC15 RBM5 RPL35A IGF2BP1 PQBP1 SRRT PPP2CB;PPP2CA SNRNP200 CTNNBL1 APOBEC1 APOBEC2 ADAR ADARB1 A1CF PRCC CCAR1 TFB1M PCBP1 PAN2 PCBP2 PAN3 SYMPK RBM10 DHX15 DHX16 TGS1 SMG1 SMG9 WBP11 SMG7 SMG8 SMG5 SMG6 UPF1 DDX46 DDX42 RBM17 BUD31 RBM22 DDX23 CSTF2T SMNDC1 U2SURP CLP1 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SF3A3 SF3A1 SF3A2 XAB2 CPSF7 RPL5-1 CHERP PUF60 SNRPB2 AQR PRPF19 PCF11 EFTUD2 RPS15 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME%R-HSA-9665233.3 Resistance of ERBB2 KD mutants to trastuzumab CDC37 ERBB2 ERBIN HSP90AA1 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702590.2 gilteritinib-resistant FLT3 mutants FLT3 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm SMAD2;SMAD3 LEF1 FOXA2 TEAD2 CTNNB1 YAP1-1 TEAD4 TCF7 FOXH1 SHH NOTO FOXA1 TBXT ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria SFN YWHAZ BAD PPP3R1 YWHAQ BCL2 YWHAH YWHAG AKT2 AKT3 BID PPP3CC YWHAE YWHAB AKT1 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 HES1 MAMLD1 GZMH;GZMB-1 MIB2 DLL4 FCER2 HES5 PSENEN NEURL1 MIB1 JAG1 UBA52 ADAM10 CNTN1 RBPJ DLL1 JAG2 PSEN1 MAML2 EP300 MAML1 RPS27A NCSTN PSEN2 UBB;UBC NEURL1B APH1A APH1B MAML3 NOTCH2 MDK PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 97%69183 Processive synthesis on the lagging strand PRIM2 RPA1 PRIM1 RPA2 POLA1 POLA2 POLD3 POLD4 DNA2 RPA3 POLD2 LIG1 FEN1 POLD1 PCNA TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids SLC27A1 LCN15 SLC27A4 LCN12 APOD LCN1 SLC27A6 CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.3 Clostridium neurotoxicity SYT2 SYT1 VAMP2 STX1A VAMP1 SNAP25 SV2C SV2B SV2A RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME DATABASE ID RELEASE 97%167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection CDK7 POLR2E POLR2F POLR2H GTF2F1 MNAT1 RNMT GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 RNGTT SUPT5H POLR2J;POLR2J2;POLR2J3 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH HS-GAG DEGRADATION%REACTOME%R-HSA-2024096.6 HS-GAG degradation HSPG2 GPC6 HPSE IDS AGRN CTSV;CTSL SGSH SDC1 NAGLU GPC1 SDC4 GPC3 IDUA SDC2 GPC2 SDC3 GPC5 HPSE2 GPC4 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME DATABASE ID RELEASE 97%4720475 Defective ALG3 causes CDG-1d ALG3 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%8957275 Post-translational protein phosphorylation FGF23 P4HB APOB APOL3;APOL4;APOL1;APOL2 MSLN BPIFB2 SDC2 MFGE8 CST3 APP DNAJC3-1 IGFBP7 WFS1 PNPLA2 ALB DMP1 CALU ANO8 VCAN MATN3 SPP2 MELTF AHSG PDIA6 TNC APLP2 APOA2 APOA1 SCG3 CKAP4 KTN1 APOA5 LOC110384692;C4A;C4B_2;C4B FBN1 GPC3 CP CSF1 IGFBP1 LAMB2 MEN1 LTBP1 IGFBP3 HSP90B1 TF CHRDL1 PENK QSOX1 MBTPS1 MIA3 FSTL1 FSTL3 ADAM10 PRKCSH MGAT4A-1 BMP4 FN1 LAMC1 C3-1 TIMP1 LGALS1 AMELY;AMELX SERPINA1 EVA1A CCN1 CHGB IGFBP5 IGFBP4 SHISA5 MXRA8 SPARCL1 SCG2 STC2 AMBN TMEM132A HRC FGA PRSS23 BMP15-1 FGG MEPE RCN1 ENAM NOTUM F5 AMTN VWA1 FAM20C FAM20A ITIH2 SERPINC1 AFP SPP1 KNG1 GOLM1 VGF SERPIND1 NUCB1 LAMB1 FUCA2 TGOLN2 PROC CDH2 IL6 APOE PCSK9 GAS6 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833576 CDH11 homotypic and heterotypic interactions CDH8 CTNND1 JUP CDH24 CDH11 CTNNB1 CTNNA1 APOPTOTIC EXECUTION PHASE%REACTOME%R-HSA-75153.6 Apoptotic execution phase VIM CDH1 BCAP31 KPNB1 DNM1L BMX SATB1 TJP2 DSG2 CASP6 FNTA ROCK1 CASP3 DSP BIRC2 CTNNB1 CASP8 KPNA1 PLEC HMGB1-1 PRKCQ OCLN-1 LMNB1 DFFB DSG1 DFFA HMGB2 PTK2 PAK2 PRKCD H1-0 H1-3 H1-2 H1-5 TJP1 H1-4 ACIN1 PKP1 SPTAN1 DSG3 APC ADD1 CLSPN DBNL GSN STK24 CASP7 STK26 GAS2 MAPT BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME DATABASE ID RELEASE 97%1368108 BMAL1:CLOCK,NPAS2 activates circadian expression ARNTL2 ARNTL NOCT HELZ2 MED1 NPAS2 BHLHE40 TGS1 CREBBP RXRA F7 CLOCK CARM1 CHD9 PPARA SERPINE1 NAMPT TBL1XR1 AVP NCOA1 NCOA2 NCOA6 SMARCD3 BHLHE41 KLF15 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020702 Interleukin-1 signaling PSMD12 IL1R1 PSMD11 PSMD14 PSMD13 APP PSMA7 NFKB2 PSMD8 MAP3K3 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 RIPK2 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 TOLLIP PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK FBXW11 IKBKB IKBKG IL1RN IL1R2 UBA52 CUL1 RPS27A UBB;UBC MAP3K7 MAP3K8 MAP2K4 TNIP2 UBE2V1 RBX1 MAP2K6 IRAK1 IRAK2 SQSTM1 UBE2N TAB3 TAB2 TAB1 IL1A IL1B TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 NKIRAS1 NKIRAS2 IKBIP IRAK4 TRAF2 PELI1 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 TIFA HMGB1-1 IRAK3 NFKBIA RELA NFKB1 MAP2K2;MAP2K1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression SAP130 SUDS3 SAP30BP CDK7 MNAT1 BAZ2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SIN3B SIN3A H2BC21 SMARCA5 UBTF DNMT3B H2AC20 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 SUV39H1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 HDAC2 HDAC1 TAF1D SIRT1 TAF1B TAF1C SAP30L H2AJ TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H POLR2L H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 ERCC3 MBD2 H2BC1 ERCC2 GTF2H1 GTF2H3 GTF2H4 ARID4B TTF1 H2AC4 SAP30 CCNH DNMT1 RRP8 H2AC14 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764260 Regulation of Expression and Function of Type II Classical Cadherins CTNND1 TNRC6C MOV10 TNRC6A-1 AGO4 SNAI1 AGO2 CDH11 CTNNB1 AGO3;AGO1 TNRC6B ADAM33 CTNNA1 CDH8 JUP ADAM19 ANGPTL4 CDH24 SP1 SOX10 CDH19 PRDM8 HEYL ILF3 FOXF1 BHLHE22 HOXC8 ZC3H12A ZEB2 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%5663202 Diseases of signal transduction by growth factor receptors and second messengers MARK3 AKT2 AKT3 FXR1-1 DLL4 PPP1CC NEURL1 HDAC11 IRF4 HDAC5 AGK HDAC9 HDAC6 HDAC7 STAT5A STAT5B EGF ERBB2 PLCG1 EGFR PDGFRA FGF6 CARS1 AKAP9-1 PPP1CB RAP1B ESRP1 HGF GAB1 MET PPP2R1A TYK2 AREG MIB2 SKP1 EEF1G HSP90AA1 FGF7 FGF22 FGF3 FGF10 WNT3A UBA52 TSC2 STAT1 CUL1 KIF5B CCNB1 VCP-1 RPS27A UBB;UBC KLC1 CASP9 RPS6 MAPK9 MAPK8 CEP43 BCL2L11 BAD STAT3 BCL2L1 HEY1 SQSTM1 HEY2 JAK2 FLT3 ADAM10 GSK3A ADAM17 TNKS TNKS2 PDPK1 PSEN1 NCSTN PTPN11 FOXO4 FOXO3 CALM3;CALM1 IL10 MSN RB1 TGFA YES1 FOXO1-1 DUSP6 CCNC-1 DUSP7 MYH9 CREBBP IHH SMAD2;SMAD3 MAML2 MAML1 IQGAP1 MAPKAP1 JUNB MAML3 SEL1L JUN SNW1 MAMLD1 CDKN1A CDKN1B NCOR2 KAT2B RAC1 KAT2A NRG1 NCOR1 NRG2 EREG BTC NRG3 NRG4 HBEGF CBL RICTOR NTF3 ITGA2B EP300 PSEN2 APH1A APH1B TBL1XR1 DNMT1 MDM2-2 NPM1-2 CDK8 PSENEN GSK3B PRR5 MLST8 SMAD4 PIK3CD PIK3CG ESR2 NR4A1 CAMK2B CAMK2D HDAC2 CAMK2A HDAC3 HDAC1 HES1 CAMK2G MTOR KANK1 HDAC10 POLR2E POLR2F POLR2H SHC1-1 POLR2L ITGB3 LYN FGB FGA NTRK2 BDNF FGG TGFBR1-1 TGFBR2 MAP2K2;MAP2K1 RAP1A MAPK1 BRAF MAPK3 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 FGF20 SOS1 FGF23 GZMH;GZMB-1 PIK3R3 PIK3R6 PIK3R5 KDM7A HDAC8 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 RBPJ DLL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 ATIC PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 RAF1 YWHAB KIT NTRK3 AKT1 VWF SYVN1 DERL2 OS9 BCR FLT3LG PDGFB CD19 RBX1 CD28 STRN GAB2 PRKAR1A CD86 KLB CD80 PDGFRB FGF19 FGFR4 AKT1S1 TRAT1 RPS6KB2 PIK3AP1 CSNK1A1 CLCN6 FGFR1OP2 ZC3HAV1 JAG2 PTEN FN1 FKBP1A PPFIBP1 SHH DUSP8 DUSP9 SPRED3 SPRED2 NEURL1B SPRED1 HHAT HRAS FYN NRAS KIAA1549 NF1 KDR TRIM24 GTF2F1 GTF2F2 GRB2 IL22 AGTRAP CNKSR2 CNKSR1 AGGF1 PEBP1 EPGN ARRB1 TPR TENT4A MYO18A ETV6 WDCP AP3B1 TPM4 TPM3 POLR2J;POLR2J2;POLR2J3 TFG CLIP1 CTBP2 CTBP1 ICOS WDR48 APBB1IP NCBP1 IL10RA GOLGB1 FAM114A2 MCL1 MAP3K11 POLR2A FIP1L1 IRS2 POLR2B POLR2C POLR2D POLR2G POLR2I LCK RANBP2 TLN1 SRC HIP1 FZD5 FZD4 NCBP2-1 FZD6 FZD8 LMNA ARRB2 CSK CPSF6 FGFR3 FGFR2 FGFR1 CHUK TRIP11 EIF2AK3 HES5 ARAF MPRIP SND1 SPTBN1 EML4 DHH CLTC ERLIN2 NOX4 AMER1 PPP2CB;PPP2CA HEYL AXIN1 PPP2R5B PIM1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG APC PORCN PPP2R5E QKI CDC37 ZC3HC1 ERBIN VAV1 FOXM1 ATG7 PHB KSR1 KSR2 PPM1B BIRC6 LRP5 LRP6 PRF1 GCC2 TRAK1 FGF2 SEC31A HDAC4 MIB1 JAG1 ESR1 VCL LRRFIP1 BCL2A1 DCTN1 RRBP1 ALK ERLEC1 IRS1 TP53 LMO7 PIK3R2 PIK3CB FAM131B DKK1 PIK3R1 DKK2 DKK4 BIN2 MYC BRAP FRS2 PIK3CA MRAS PTPN6 TNRC6C MOV10 AGO4 AGO2 AGO3;AGO1 TGFB1 KRAS RNF43 BAG4 DUSP16 DUSP10 CEBPB PTPN12 GOLGA4 BCL11A TCF7L2 RNF213-2 ZMYM2 KREMEN1 KREMEN2 PAPSS1 ZAP70 CUX1 SHOC2 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 97%2473224 Antagonism of Activin by Follistatin INHBB INHBA FSTL3 FST COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding GNA14 GNG10 CSNK2A2 GNA15 GNG2 GNG5 GNG4 GNA11 CSNK2A1;CSNK2A3 GNG8 CCT8 CCT7 CSNK2B CCT5 CCT4 GNG13 CCT6A GNAQ GNB2 GNB1 PDCL CCT6B GNB4 GNB3 GNGT1 GNB5 RGS11 RGS9 RGS6 RGS7 CCT3 CCT2 TCP1 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 97%2028269 Signaling by Hippo STK4 STK3 LATS1 TJP2 LATS2 CASP3 TJP1 WWC1 YAP1-1 WWTR1 YWHAE YWHAB AMOTL2 AMOTL1 SAV1 MOB1A;MOB1B DVL2 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors GRIK1 GRIK2 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 97%1566948 Elastic fibre formation ITGB1 BMP10 ITGB5 ITGB8 EFEMP2 EFEMP1 ITGAV ITGB6 TGFB1 FBN2 FBN3 VTN FBLN1 FBLN2 FBLN5 ITGB3 BMP7 FBN1 FURIN BMP4 BMP2 ITGA5 LOXL3 MFAP5 ITGA8 LOXL4 MFAP4 MFAP3 LTBP4 MFAP2 LTBP2 LOXL1 LTBP3 LOXL2 LTBP1 TGFB2 TGFB3 GDF5 LOX MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1362409 Mitochondrial iron-sulfur cluster biogenesis ISCA2 ISCA1 LYRM4 FDXR GLRX5 HSCB SLC25A28 FDX1 SLC25A37 FXN NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 CXCL12 NRG1 NRG2 NCOR1 PSENEN EREG BTC NRG3 NRG4 HBEGF WWOX TAB2 ESR1 ADAM17 STAT5A SRC PSEN1 PGR YAP1-1 NCSTN GFAP PSEN2 CSN2-1 APH1A SPARC APH1B APOE MXD4 STMN1 ADAP1 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.2 RUNX3 Regulates Immune Response and Cell Migration RUNX3 ITGA4 SPP1 ITGAL CBFB CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.7 ChREBP activates metabolic gene expression ACLY ACACB ACACA FASN MLX AGPAT1 REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling N4BP1 USP18;USP41 IKBIP TRAF2 CHUK LRRC14 CASP8 USP14 RPS27A NLRC5 TRAF6 TP53 UBB;UBC IKBKB IKBKG NLRX1 UBA52 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%450341 Activation of the AP-1 family of transcription factors JUN MAPK1 MAPK14 MAPK11 MAPK3 FOS MAPK9 MAPK8 ATF2 MAPK10 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 97%9932298 Degradation of CRY and PER proteins PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 PER2 PER1 CRY2 CRY1 FBXW11 UBA52 PSMD12 PSMD11 PSMD14 FBXL3 PSMD13 CUL1 UBE2D1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells EPHA5 EPHA7 EPHA6 EPHA8 EPHA1 EPHA3 RAC1 EPHA10 YES1 PSENEN MMP2 MMP9 EPHA2 CLTC LYN CLTA AP2A1 ADAM10 AP2B1 TIAM1 AP2A2 DNM1 EFNA5 EFNA4 AP2S1 EFNB2 EFNB1 EFNB3 EFNA1 PSEN1 EFNA3 EFNA2 VAV3 NCSTN PSEN2 CLTB APH1A APH1B VAV2 FYN EPHA4 EPHB6 CLTCL1 EPHB2 EPHB1 EPHB4 EPHB3 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 97%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) PTGIS CYP8B1 TBXAS1 PTGDS CBR1-1 PTGS1 HPGDS PTGES3-1 HPGD PTGS2-2 PRXL2B PTGES2 PTGES PTGR2 MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.2 mRNA Polyadenylation NCBP1 TRA2B PHF5A SNRPD2 PAPOLA SNRPD1 SNRPN SNRPD3 DNAJC8 POLR2A FIP1L1 POLR2B POLR2C POLR2D SRRM2 POLR2G SNRPE-2 POLR2I CSTF3 CSTF2 NCBP2-1 HNRNPH2 RBBP6 PTBP1 PPP1CB HNRNPH1 CPSF4 HNRNPA1-1 CPSF1 CPSF3 HNRNPM PPP1CA RBM5 SF3B1 RBMX UBA52 SRRT RPS27A UBB;UBC SNRPF U2AF1L5;U2AF1 CCAR1 SNRPB DDX5 PCBP1 PCBP2 SYMPK CDC40 RBM10 DHX15 SRSF2 SRSF3 SRSF5 HNRNPC SRSF6 TCERG1 SRSF7 SRSF9 SRSF1 U2AF2 DDX46 DDX42 SRSF11 RBM17 SRSF4-1 HTATSF1 PPP1R10 CSTF2T CPSF2-1 PRPF40A SMNDC1 U2SURP TUT1 NUDT21 CLP1 SRSF10 SRSF12 YBX1 FUS PAPOLG SNRPG-2 HNRNPA3 SF3B4 SF3B5 SNRPC SF3B2 SNRPA SF3B3 PPP1R8;STX12 SF3B6 SF3A3 SF3A1 SF3A2 POLR2E DHX9 CPSF7 POLR2F GTF2F1 POLR2H GTF2F2 SUGP1 RBM25 PABPN1-1 POLR2L CHERP SNRNP70 PUF60 RBM39 SNRPB2 HNRNPF POLR2J;POLR2J2;POLR2J3 HNRNPA2B1 HNRNPU HNRNPR SNRPA1 PCF11 HNRNPL XRN2 HNRNPK HNRNPD WDR33 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events TRIM28 NUP133 DYNC1LI1 DYNC1LI2 ITGB1 NUP50 POM121;POM121C NUP54 DYNC1I1 H2BC18 NUP42 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 NUP43 H2BC21 RAE1 RANBP2 DAXX H2AC20 EED EZH2 NUP35 CBX1 EGFR NUP37 HDAC3 PML NUP107 NUP188 RBBP4 NCOR2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NUP210 NCOR1 RBBP7 NUP93 NUP205 GPS2 H2BC15;H2BC3;H2BC11;H2BC12 AAAS SUZ12 H2BC5 NUP160 NUP85 H2BC1 NUP214 DYNC1I2 TPR NUP88 NUP155 NUP153 ELK1 H2AC16;H2AC11 H2AC4 NFKB1 NUP62 TBL1XR1 DYNC1H1 NDC1 H2AC14 SEC13 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME%R-HSA-9665244.2 Resistance of ERBB2 KD mutants to sapitinib CDC37 ERBB2 ERBIN HSP90AA1 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210990 PECAM1 interactions LCK PTPN6 PTPN11 PECAM1 PLCG1 ITGB3 FYN LYN INPP5D ITGAV YES1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle UNC13B RAB3A SYT1 SLC38A2 VAMP2 STX1A CPLX1 ARL6IP5 SNAP25 RIMS1 PPFIA1 PPFIA4 GLS2 PPFIA3 PPFIA2 SLC17A7 GLS TSPOAP1 SLC1A1 SLC1A2 SLC1A3 SLC1A6 SLC1A7 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 GGCX F9 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%5579009 Defective CYP11B2 causes CMO-1 deficiency CYP11B1;CYP11B2 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 97%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation SYK FGR HCK FCGR3A;FCGR3B FYN FCGR1A LYN YES1 CD3G PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism TAT ASRGL1 KYAT1 HPD GSTZ1 PAH QDPR HGD FAH PCBD1 IL4I1 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 97%392518 Signal amplification AAMP PLA2G4A GNA13 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 GNG13 GNAQ GNB2 GNB1 GNB4 GNB3 GNGT1 TBXA2R P2RY1 GNB5 P2RY12 GNAT3 GNAI1 GNAI3 GNAI2 MAPK14 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 97%189085 Digestion of dietary carbohydrate TREH CHIT1 AMY1A;AMY1C;AMY1B;AMY2A;AMY2B SI LCT MGAM GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977444 GABA B receptor activation KCNJ2 KCNJ12;KCNJ18 KCNJ3 KCNJ4 GNG10 GABBR2 GNG2 KCNJ5 GNG5 GABBR1 ADCY9 GNG4 KCNJ6 KCNJ10 GNG8 KCNJ9 ADCY4 ADCY3 KCNJ15 KCNJ16 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 GNB2 GNB1 GNAL GNB4 GNB3 GNGT1 GNB5 GNAT3 GNAI1 GNAI3 GNAI2 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 97%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD BCKDHA DBT BCKDHB MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling GAB1 MET ARF6 RAB4B CRK RAB4A CRKL GGA3 HGF RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8941855 RUNX3 regulates CDKN1A transcription RUNX3 TP53 SMAD2;SMAD3 ZFHX3 CDKN1A TGFB1 SMAD4 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 97%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 97%199991 Membrane Trafficking COG4 GJA1 COG3 PLA2G4A COG2 SPTBN2 BET1L RAB30 RAB36 AKT2 AKT3 CTSC GJC1 ALPG;ALPP;ALPI-1 GJC2 GJA3 MAP1LC3B2;MAP1LC3B-1 AGPAT3 GJA10 CAPZA3 GJA5 STXBP3 ACTR10 GJA4 STX4 GJA9 GJA8 GJD2 GJD4 SAR1B GJD3 GJB4 GJB3 GJB6 GJB5 GJB7 GOLGA2 SFN DCTN6 DCTN5 DCTN4 APP RAB4A GRIA1 M6PR SYNJ2 NSF SCARB2 SYNJ1 AGFG1 EGF STON1-GTF2A1L KIAA0319 RAB5A EGFR TOR1A TOR1B YWHAE SYT9 SYT8 SNAP91 STON2 PIK3C2A SLC2A8 SLC18A3 SGIP1 EPN2 VAMP4 ACTR1A FCHO1 FCHO2 UBQLN1 REPS2 AREG REPS1 UBQLN2 NECAP2 EPS15 SYT11 YWHAG RAB8A MYO5A OPTN-1 MYO1C CSNK1D RAB14 UBA52 PAFAH1B1 TSC2 AP4M1 DYNC1I2 TSC1 AP1G2 DCTN2 DNASE2 DCTN3 CLVS2 SEC24D-1 AP4S1 CLVS1 TJP1 KIF5B KIF5A MAN2A2 KIF21A KIF21B KIFAP3 KIF4B;KIF4A KIF16B KIF20A RPS27A KIF20B UBB;UBC KLC1 DYNC1H1 KLC4 KLC3 KLC2 RACGAP1 KIF3B KIF3C KIF18A KIF18B ANK1 KIF12 MAN2A1 KIF11 KIF15 INS;INS-IGF2 KIF19 CAPZB KIF13B MAN1A2 KIF1C MAN1C1 KIF1B MAN1A1 KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIF2A KIFC2 YWHAQ KIFC1 YWHAH KIF2C KIF2B CENPE SEC23A KIF26A CAPZA1 KIF26B CAPZA2 USP6NL BICD1 SEC24B SCOC BICD2 SEC24A SYS1 GALNT2 PAFAH1B3 GCC1 GALNT1 PAFAH1B2 GOLGA1 ARFIP2 RINT1 KDELR2 VPS45 COPB2 SEC24C COPA ARL1 COPE USE1 RABEPK TMED3 TMED7 NAA30 TMED9 COPZ2 HGS COPZ1 CALM3;CALM1 NAA35 RAB7A NAA38 ARF5 NBAS TMF1 STX18 STX10 ARFRP1 VPS51 VPS53 VPS52 BNIP1 VPS54 ARCN1 COPG2 COPG1 RALA-1 VAMP7 DENND5B RABGEF1 RINL TBC1D10C TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TBC1D10A ARFGAP1 TBC1D10B GABARAPL2 TRAPPC2L SYTL1 GAPVD1 RAB32 RAB31 TBC1D20 TBC1D7;TBC1D7-LOC100130357 PREB RAB35 KDELR3 TBC1D24 TBC1D25 DENND6B RIN3 RAB38 ULK1 DENND6A RIN1 TGFA RIN2 GABARAP TBC1D13 TBC1D14 TBC1D17 RAB6B CCZ1;CCZ1B TBC1D15 TBC1D16 TRAPPC3 TRAPPC1 GOSR2 ANKRD27 DENND4B DENND4A TRAPPC4 TRAPPC5 DENND4C HPS1 RAB39A HPS4 MYH9 RAB27A RAB39B RAB27B TRAPPC8 TRAPPC9 CHRM2 MON1A MON1B DENND1C DENND1B ADRB2 GDI1 DENND1A ARF4-1 PRKAB1 GDI2 RAB8B DENND2D DENND2C TRAPPC2;TRAPPC2B DENND2B DENND2A RAB3IL1 RAB33A TRAPPC6A TBC1D2 TMED2-1 RABEP1 TRAPPC6B RAB7B RAB3IP ARF6 RAB1A RABGAP1 RAB1B RAB21 GGA2 GGA1 ALS2CL GGA3 CHML RIC1 TRAPPC10 RAB6A RAB33B-1 RAB11B RGP1 RAB10 RAB13 RAB18 RAB3GAP2 ARF1 RAB3GAP1 EXOC8 PRKAG1 EXOC7 CHM RAC1 PRKAG3 EXOC4 EXOC3 EREG EXOC6 BTC EXOC5 EXOC2 EXOC1 HBEGF GBF1 RAB11A CBL VAMP2 BIN1 SNX18-1 GJB2 RALGAPA2 GJB1 RALGAPB C2CD5 MIA2 MIA3 AMPH PACSIN2 PACSIN3 PACSIN1 TMEM115 TBC1D1 TBC1D4 GRK3 AGTR1 LRP2 TACR1 F5 SLC2A4 COPS7B F8 COPS7A COPS3 COPS6 COPS5 COPS8 SNAP29 APOB CD4 PRKAB2 WASL GRK2 PIP5K1C ANK3 IL7R VPS36 SNF8 EPS15L1 VPS25 EPN1 PRKAG2 SBF1 SBF2 CPD YWHAB PICALM COL7A1 AKT1 RAB3A SYT1 YWHAZ COPB1 ITSN2 CD59 CD55 TFRC ITSN1 HSPA8 FNBP1L FNBP1 TF DYNC1LI1 DYNC1LI2 SURF4 MYO6 KIF3A CTSZ ARPC1A CD3G VAMP3 GPS1 LMAN1 STX5 YKT6 PRKAA2 MCFD2 SERPINA1 PPP6C PPP6R1 PPP6R3 LMAN1L GORASP1 SEC22A SEC22C NAPB CHMP4C CHMP4B TMED10 STX17 CHMP4A VPS28 LMAN2L USO1 NAPG TSG101 LMAN2 SEC31B ANKRD28 SEC23IP EPGN CNIH1 AP4E1 ARRB1 CRYZL2P-SEC16B;SEC16B CLINT1 CNIH2 AP1G1 FOLR1 CNIH3 FTH1 SYT2 AP1S2 BET1 AP1S1 LDLRAP1 AP1S3 SH3D19 TPD52 VTA1 AP1B1 AP3B1 AP3S2;AP3S1 VAMP8 GAK CHMP2B DNAJC6 NAPA RAB5C CHMP2A TGOLN2 TFG BLOC1S4 BLOC1S6 SPTB SNX2 BLOC1S1 BLOC1S3 RHOBTB3 SNX9 AP1M2 SNX5 TXNDC5 AP1M1 TBC1D8B FTL-1 SNAPIN DVL2 SORT1 HIP1R SEC13 DTNBP1 TPD52L1 PUM1 VPS37C AP4B1 ARPC4 VPS37D IGF2R ARPC5 VPS37A NECAP1 ANK2 VPS37B GOLGB1 COPS4 YIPF6 ACBD3 ARPC2 ARPC3 CHMP3 RAB5B COPS2 SPTBN4 SPTBN5 CHMP6 CHMP7 CHMP5 AVPR2 SNAP23 VPS4B VPS4A MVB12B ACTR2 MVB12A ARFGAP3 COG1 ARFGAP2 WNT5A SPTA1 HIP1 FZD4 UBAP1 CLTB ARRB2 DAB2 CLTCL1 ZW10 TRIP11 CFTR SCFD1 SPTBN1 STAM CLTC CLTA AP2A1 AP2B1 AP2A2 DNM1 DNM2 DNM3 AP2S1 SH3GL2 SPTAN1 CTTN LNPEP KDELR1 RHOQ GCC2 SEC31A DYNC1I1 SH3GL3 SH3GL1 TRIP10 RAB9A RAB9B CD3D DCTN1 SEC22B STAM2 GNS OCRL PLA2G6 ACTR3-1 GOLGA4 PLIN3 SH3KBP1 STX16 GOSR1 GOLIM4 CYTH3 CYTH2 GOLGA5 AVP ALS2 LDLR CYTH4 STX6 CUX1 VTI1A CYTH1 COG8 COG7 COG6 COG5 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 97%449147 Signaling by Interleukins TBK1 PTK2B IL21 S1PR1 VIM TNF STX4 IL4R IL13 VCAM1 IRF4 CCL3L1;CCL3L3;CCL3;CCL18 ITGB2 POMC STAT6 APP STAT5A STAT5B NFKB2 POU2F1 CASP1 SDC1 BATF IL4 IL5 JAK1 RIPK2 RAP1B PRKACA-1 HGF PPP2R1A TYK2 IL17RC TNFRSF1A BTRC IL17RA SKP1 HSP90AA1 CANX FBXW11 SOX2 UBA52 STAT1 STAT2 CUL1 CSF1 IL17F ATF1 RPS27A ELK1 IL17A RPS6KA3 RPS6KA5 RPS6KA2 UBB;UBC MAP3K7 RPS6KA1 GSDMD MAP3K8 MEF2A MAP2K3 TNFRSF1B MAP2K4 MEF2C MAPKAPK3 MAPK9 MAPK8 MAP2K7 HSP90B1 MAPK10 TNIP2 UBE2V1 STAT3 BCL2 BCL2L1 IRAK1 IRAK2 COL1A2 IL9 IL9R SQSTM1 JAK2 UBE2N TAB3 TAB2 TAB1 IL23R IL23A IL18 IL1A CDC42 IL1B TRAF6 RORC NOD1 NOD2 CAPZA1 PTPN11 CASP3 CTSG TIMP1 PTPN7 IL34 FOXO3 ALOX15 MMP1 NOS2 MMP2 MMP3 MMP9 PITPNA LMNB1 CNN2 HNRNPDL CFL1 STAT4 IL12B IL12A IL12RB1 PAK2 IL12RB2 IL10 SERPINB2 LAMA5 ANXA2 MSN MIF RALA-1 SOD2 SOD1 VAMP7 IFNG HNRNPF HNRNPA2B1 PDCD4 PSME2 SNRPA1 LCP1 IL2RA TCP1 PTPN4 YES1 DUSP4 FOXO1-1 DUSP3 VRK3 DUSP6 DUSP7 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 VEGFA ATF2 SMAD2;SMAD3 SMARCA4 IL2 IL3 JUNB CD36 JUN MAPK7 CDKN1A ARF1 RPLP0 FPR1 CRK FOS CBL SOCS3 VAMP2 CSF2 MAP2K6 FCER2 OPRD1 BCL6 IL21R LIFR PIK3CD BIRC5 OPRM1 SOCS5 FASLG TRAF2 CASP8 SHC1-1 F13A1 ANXA1 LYN NFKBIA PTAFR TSLP IL31RA IL18BP CCR2 IFNL2;IFNL3;IFNL1 MAP2K2;MAP2K1 STX3 RAPGEF1 CRLF2 MAPK1 MAPK3 CRKL SOS1 STX1A PIK3R3 IL2RB P4HB IL36A IL36B BRWD1 CD4 IL36G MUC1 IL1F10 LCN2 IL20 IL25 IL26 IL24 PSMD12 IL11 PSMD11 IL15 PSMD14 IL19 PSMD13 IL16 PSMA7 PSMD8 MAP3K3 PSMB6 IL31 PSMB7 PSMD6 IL37 PSMB4 OSM PSMD7 IL18R1 PSMB5 PSMB2 PSMB3 RAG2 PSMD2 RAG1 PSMD3 PSMB1 PSMD1 IL36RN ADRM1 IL7R PSMC2-1 PSMA2-1 PSMA5 IL1RL2 SEM1 TEC PSMA6 CNTF PSMC5 PSMA3 PSMC6 TOLLIP PSMA4 PSMC3 PSMA1 IL10RB PSMC4 CLCF1 PSMC1 CSF3 IL5RA GSTO1 IL13RA2 IL13RA1 IL1RN IL1R2 AKT1 STXBP2 LIF YWHAZ MAPKAPK2 LBP IL11RA ITGAM IL20RA IL20RB IL22RA2 IL22RA1 HSPA8 MAPK14 MAPK11 CTF1 ZEB1 NANOG;NANOGP8 TXLNA FSCN1 IL1RAPL1 PTPN9 PTPN5 PTPN2 RBX1 GAB2 IL33 CD86 OSMR CD80 IL17C IL1RL1 IL7 CNTFR SNAP25 FN1 SYK HAVCR2 EBI3 HCK IL27 IL6ST CRLF1 IL27RA FYN CSF3R LGALS9C;LGALS9;LGALS9B ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 NDN MYD88 NFKBIB PTPN20 SAA2;SAA1 PTPN23 NKIRAS1 NKIRAS2 IKBIP IL3RA IRAK4 PELI1 PTPN14 LRRC14 USP14 PELI3 PELI2 IFNLR1 NLRC5 IL17RE TIFA IL17RB HMGB1-1 GRB2 IL22 IL18RAP SIGIRR IRAK3 IL6R TALDO1 PTGS2-2 CCR5 PTPN18 IL10RA CSF2RB CSF2RA MCL1 GSTA3;GSTA5;GSTA1;GSTA2 CEBPD CISH IRS2 AIP SOCS2 SOCS1 IL1R1 LCK SOS2 CXCL8 CHUK INPPL1 BLNK CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 PTPN13 CCL4L2;CCL4L1;CCL4 IKBKB CCL5 IKBKG CCL19 CCR1 CCL22 CCL20 ITGAX CXCL10 PPP2CB;PPP2CA PIM1 PPP2R5D PPP2R1B VAV1 RHOU MAOA CA1 ITGB1 GATA3 INPP5D FGF2 RORA PPIA IRS1 TP53 PIK3R2 PIK3CB MTAP PIK3R1 IL2RG HIF1A PTPRZ1 MYC JAK3 PIK3CA PTPN6 HMOX1 TGFB1 CCND1 ALOX5 HSPA9 CSF1R PTPN12 RELA NFKB1 IL6 ICAM1 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors TFAP2A TFAP2C CITED2 PITX2 LGK974 INHIBITS PORCN%REACTOME DATABASE ID RELEASE 97%5340573 LGK974 inhibits PORCN PORCN ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects E2F2 CDK6 CDKN1A CDKN1B CCND1 CCND3 CCND2 ANAPC15 ANAPC16 UBE2D1 ANAPC10 CDK4 ANAPC11 CDK2 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 SKP2 TFDP1 UBE2S TFDP2 CDC16 CCNE2 ANAPC4 CCNE1 ANAPC5 RB1 ANAPC1 ANAPC2 CDKN1C E2F1 E2F3 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 97%964739 N-glycan trimming and elongation in the cis-Golgi MANEA MAN1A2 MAN1C1 MAN1A1 MGAT1 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression CSNK2A1;CSNK2A3 WWTR1 SPOP PRKAB2 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 RPN2 CREBBP RPN1 PSMD12 PSMD11 PSMD14 PSMD13 LEF1 PRKAB1 H2AC20 PSMA7 NFKB2 PSMD8 H2AB2;H2AB3;H2AB1 EZH2 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 ASH2L PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 MAGT1 JAK1 ADRM1 SEL1L PSMC2-1 PSMA2-1 PRKAG2 PSMA5 SEM1 PSMA6 JUN PSMC5 PSMA3 PSMC6 PSMA4 NEK2 MIB2 BTRC NFE2L2 PSMC3 PSMA1 TEAD1 YWHAG PSMC4 PRKAG1 TEAD2 PSMC1 SKP1 TEAD3 CTNNB1 H2AJ TCF7 PRKAG3 TEAD4 TCF7L1 FOS SUZ12 H2BC5 UBA52 EPAS1 H2BC1 ERLIN1 ERLIN2 STAT1 CUL1 CDK4 ATF3 EP300 PDCD1LG2 VCP-1 RPS27A TUSC3 DERL2 H2AC4 RNF5 UBB;UBC OS9 RNF185 KMT2A KMT2C TMEM258 RBX1 STAT3 GSK3B OST4 DERL3 DERL1 DPY30 OSTC STT3A STT3B H2BC21 WDR5 IRF1 EED DDOST H2AZ2;H2AZ1 DAD1 ERLEC1 CD274 B3GNT3 HIF1A PRKAA1 CUL3 MYC JUND MYCN TNRC6C MOV10 CSNK2A2 TNRC6A-1 PDCD1 AGO4 PRKAA2 RBBP4 AGO2 RBBP5 BRD4 AGO3;AGO1 FOSB TNRC6B H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 CSNK2B RBBP7 H2BC15;H2BC3;H2BC11;H2BC12 RELA YAP1-1 TCF7L2 NFKB1 COPS5 H2AC14 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%5368286 Mitochondrial translation initiation MRPS17 MRPS15 MRPS16 MTFMT MRPS14 MRPS11 MTIF2 MRPS12 MTIF3 MRPL38 MRPS36 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 OXA1L AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation FGFR4 INTERLEUKIN-23 SIGNALING%REACTOME%R-HSA-9020933.3 Interleukin-23 signaling TYK2 STAT3 P4HB IL23R STAT4 IL23A IL12B JAK2 IL12RB1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 97%5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) MSH2 PMS2 RPA1 RPA2 MLH1 EXO1 POLD3 POLD4 RPA3 POLD2 LIG1 MSH3 POLD1 PCNA INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling SOS1 SHC1-1 ITGB3 RASGRP2 CRK RASGRP1 PTK2 FGB AKT1 FGA FGG RAPGEF3 ITGA2B PTPN1 RAPGEF4 TLN1 VWF PDPK1 BCAR1 SRC FN1 SYK RAP1A CSK RAP1B APBB1IP DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane F8 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%76046 RNA Polymerase III Transcription Initiation POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H POLR2L ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 BRF2 TBP BDP1 POU2F1 GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR1C GTF3C5 POLR1D BRF1 GTF3A GTF3C6-1 CRCP NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 97%194441 Non-coding RNA Metabolism GEMIN4 NCBP1 GEMIN5 NUP133 GEMIN6 SNRPF SNRPD2 GEMIN7 SNRPD1 GEMIN8 NUP50 POM121;POM121C SNRPB SNRPD3 NUP54 PHAX NUP42 TGS1 NUP43 SNRPE-2 RAE1 RANBP2 CLNS1A SNUPN NCBP2-1 NUP35 DDX20 NUP37 SNRPG-2 NUP107 NUP188 WDR77 SMN2;SMN1 NUP210 PRMT5 NUP93 NUP205 AAAS NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 GEMIN2 NUP62 NDC1 SEC13 PI METABOLISM%REACTOME DATABASE ID RELEASE 97%1483255 PI Metabolism PIK3R3 FIG4 PIK3R6 PIK3R5 INPP5F INPP5D INPP5E INPP5J INPP5K TPTE;TPTE2 BMX RUFY1 PIK3R4 GDPD1 PIKFYVE TNFAIP8L1 GDPD3 TNFAIP8L3 MTM1 MTMR1 GDPD5 TNFAIP8L2 MTMR2 PIP4K2A MTMR3 RAB4A PTEN PIP4K2B PIP4K2C PI4K2B MTMR8 MTMR9 PIP5K1A PIK3CD PIP5K1B PIK3CG MTMR4 SYNJ2 PIK3C3 PIP5K1C PIK3R2 SYNJ1 PIK3CB PITPNB MTMR6 RAB5A PIK3R1 MTMR7 MTMR10 MTMR12 MTMR14 PIK3C2G PLEKHA1 PIK3C2A PNPLA7 PI4K2A PLEKHA2 PIK3C2B PLEKHA5 PLEKHA6 PIK3CA PLEKHA3 PLEKHA4 PLEKHA8 ARF1 PNPLA6 INPPL1 SBF1 SBF2 PTPN13 OCRL ENPP6 RAB14 PIP4P1 GDE1 PI4KA SACM1L PI4KB INPP4A INPP4B VAC14 TNFAIP8 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling ARHGEF7 SOS1 GNA13 ARHGEF5 BCL2L11 ARHGEF6 BAD NGEF IRAK1 PSENEN ABR RASGRF2 LINGO1 MAG OMG RTN4 SQSTM1 PLEKHG2 ADAM17 ARHGEF33 ARHGEF37 ARHGEF38 SOS2 PSEN1 CASP2 NCSTN PRKCI TRAF6 ARHGDIA ARHGEF40 YWHAE PRDM4 FGD1 NGFR FGD2 FGD3 FGD4 RIPK2 HDAC2 ARHGEF26 BEX3 HDAC3 HDAC1 MYD88 SMPD2 CASP3 PLEKHG5 MCF2 RAC1 ECT2 RHOA ARHGEF39 KALRN IKBKB NET1 UBA52 NFKBIA NGF TIAM1 ARHGEF10L AKAP13 RELA MCF2L ARHGEF11 AATF ARHGEF10 ARHGEF12 MAGED1 VAV3 ARHGEF15 ARHGEF17 RPS27A TRIO ARHGEF16 PSEN2 ARHGEF19 ARHGEF18 UBB;UBC NFKB1 ITSN1 VAV1 APH1A VAV2 APH1B TIAM2 PREX1 ARHGEF3 ITGB3BP ARHGEF4 MAPK8 ARHGEF1 ARHGEF2 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 97%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability TP53 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.2 SWI SNF chromatin remodelers ACTL6A DPF1 DPF2 DPF3 SMARCC1 SMARCC2 BICRAL BICRA ACTB-1 BRD9 SMARCE1 BCL7A SS18L1 PBRM1 BCL7C ACTL6B BCL7B SMARCA2 BRD7 SMARCA4 PHF6 BCL11A ARID1A ARID1B SMARCD1 SMARCB1 BCL11B SMARCD2 ARID2 PHF10 SS18 SMARCD3 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes TXN AKT2 SLC38A9 AKT3 PRKAB2 COX7B RHEB COX7C COX8A SCO2 SFN TP63 COX8C YWHAQ PRKAB1 YWHAH RRAGA RRAGC RRAGB PTEN MLST8 DDIT4 RRAGD COX4I1 COX4I2 COX5B GLS TP53 PRDX2 COX5A PRDX1 YWHAE PRKAA1 RRM2B COX7A2L-1 PRKAG2 COX6C MTOR TNRC6C MOV10 TNRC6A-1 PRKAA2 AGO4 YWHAG AGO2 PRKAG1 AGO3;AGO1 GLS2 TNRC6B PRKAG3 COX6A1 RPTOR COX6A2 TXNRD1 G6PD YWHAB COX7A2 GPI AKT1 COX6B2 TSC2 TSC1 COX6B1 YWHAZ TIGAR NDUFA4 CYCS-1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 SESN3 SESN2 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition CDK1 PPP2R1A CDK7 CCNA2-1 HJURP CCNA1 MIS18BP1 BORA MNAT1 XPO1 PPP2R3B PPP2R2A;PPP2R2D CDC25A PKMYT1 CDC25B CCNB2 CCNB1 CDK2 PPP2CB;PPP2CA FZR1 PPP2R1B OBI1 LCMT1 PPME1 TICRR FOXM1 WEE1 SGO1 CCNH PLK1 CDC25C METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.3 Metallothioneins bind metals MT2A MT3 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013408 RHOG GTPase cycle ARHGEF5 ITGB1 DOCK5 IQGAP2 HSPE1 DOCK4 PGRMC2 DOCK3 MAP3K11 PAK4 MCAM CAV1 PLEKHG3 MPP7 ESYT1 ARHGAP1 ARFGAP3 DSG2 EMD SHMT2 ARHGDIG ARHGAP39 DOCK2 CDC42 CDC42EP1 ARHGDIA VAMP3 ARHGDIB PIK3R1 LMAN1 ARHGAP5 ARHGEF26 ARHGAP21 STX5 LBR YKT6 OPHN1 TMPO ARHGAP35 MCF2 LEMD3 KTN1 VANGL1 DEPDC1B GARRE1 KALRN RAB7A ELMO2 DOCK1 EPHA2 PLD1 ARHGAP32 VAPB PAK2 DIAPH3 MCF2L STBD1 CYFIP1 ANKLE2 VAV3 VRK2 TRIO ARHGEF16 TFRC RHOG LAMTOR1 ITSN1 ERBIN VAV1 VAV2 PREX1 LETM1 NDUFS3 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%70688 Proline catabolism ALDH4A1 PRODH2 PRODH;LOC102724788 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 97%9937383 Mitochondrial ribosome-associated quality control MRPS17 C12orf65 MRPS15 MIEF1 MRPS16 MALSU1 MRPS14 MRPS11 MRPS12 MRPL38 MRPS36 MTRES1 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 MRPL3 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPL49 NDUFAB1 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 MRPL48 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPS18C MRPL44 MRPL52 MRPL53 MRPL50 MRPS9 MRPL51 OXA1L AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins PDCD6IP SYT2 HSP90AB1 SYT1 VAMP2 STX1A PDZD3 FURIN VAMP1 SNAP25 SV2C SV2B SV2A HSP90AA1 CD9 EEF2 TXNRD1 CALM3;CALM1 MAP2K2;MAP2K1 MAP2K4 HBEGF MAP2K7 GUCY2C DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 97%4641258 Degradation of DVL PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 RBX1 PSMC3 PSMA1 PSMC4 PSMC1 HECW1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 KLHL12 DACT1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 CUL3 DVL1 PSMC2-1 DVL2 PSMA2-1 DVL3 PSMA5 SEM1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373076 Class A 1 (Rhodopsin-like receptors) LTB4R2 NTS MCHR2 HRH1 TAC3 TAC1 OPN4 S1PR1 NMUR2 NMUR1 MLNR HTR2B HTR2A TRH LTB4R BDKRB2 BDKRB1 DRD1 CCL3L1;CCL3L3;CCL3;CCL18 DRD2 DRD3 DRD4 DRD5 POMC P2RY6 P2RY2 P2RY1 APP CCK KISS1 FFAR3;GPR42 ADORA2A ADORA3 ADORA1 C5AR2 C5AR1 C5 LHB OPN1MW3;OPN1MW2;OPN1MW;OPN1LW ADRA1D ADRA1B ADRA1A TBXA2R FSHB C3AR1 CYSLTR1 CYSLTR2 ADORA2B OPN1SW C3-1 SAA2;SAA1 MC2R SST CCR5 AGT CHRM3 AVPR2 CXCR4 CHRM2 CHRM4 ADRB1 ADRB2 HTR4 HTR6 HTR7 HRH3 HRH2 HRH4 HTR1E TAAR8 TAAR9 MCHR1 PSAP HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 ADRB3 RXFP4 MRGPRD CXCL9 RXFP1 CXCL8 ADRA2C RXFP2 CXCL13 RXFP3 CX3CL1 ADRA2A CCRL2 CCR9 CXCL5;CXCL6 CMKLR1 AGTR2 CCR8 FPR1 CCR7 SSTR3 CCR4 GALR3 CCR3 GALR2 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 GALR1 NPBWR1 CCL11 NPBWR2 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 GPR183 CCL5 PNOC MC4R CXCR2 GPR18 CCL1 EDNRB CCL19 RHO CCL17 CCR10 EDN1 CCL16 CCR1 EDN3 GPR37 CCL25 GPR35 CCL22 CCL21 CCL20 PPBP MC3R RGR PLPPR1 CXCL10 PLPPR2 CXCL11 ACKR4 MC1R PLPPR3 ACKR2 PLPPR4 MC5R CCL28 PLPPR5 CCL27 ACKR3-2 NPFFR2 NPFFR1 NPFF P2RY12 HCRT P2RY13 PF4;PF4V1-1 P2RY14 QRFPR QRFP GPR55 LHCGR HCRTR2 FSHR HCRTR1 GPHA2 TSHR GPHB5 MTNR1A MTNR1B RLN3 ECE1 PRLHR INSL3 INSL5 P2RY4 APLN ECE2;EEF1AKMT4-ECE2 RRH PTGDR GPR37L1 KEL ADRA2B NLN PENK PPY PTGDR2 NPY4R2;NPY4R OXGR1 GPBAR1 GAL OPRD1 PTGER4 NPB PTGER2 PTGER3 NPW RLN2;RLN1 PRLH MAS1 XK HCAR1 PDYN HCAR2;HCAR3 NPY2R NPY FFAR1 NPY1R APLNR SUCNR1 OPN3 OXTR GRPR OPN5 EDNRA PYY PROK2 PROK1 UTS2R TRHR OPRM1 UTS2B HEBP1 AGTR1 PTGFR CENPS-CORT;CORT;CENPS LPAR1 LPAR2 LPAR3 CXCL12 GPER1 FPR2 LPAR4 NTSR1 NTSR2 GPR17 PTGIR NMB NPY5R XCR1 OPRK1 XCL1;XCL2 NMBR SSTR1 CGA LPAR5 SSTR2 LPAR6 NMS SSTR4 NMU SSTR5 GNRH1 MLN OPRL1 BRS3 CNR2 GPR132 CNR1 CCKAR GNRHR S1PR3 FFAR4 FFAR2 S1PR2 S1PR5 GPR39 S1PR4 EDN2 ANXA1 TACR2 TACR3 ACKR1 TACR1 CCKBR CX3CR1 NPSR1 GRP F2R PTGER1 F2 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 KNG1 F2RL1 F2RL2 CCR6 F2RL3 AVPR1B CHRM1 CCR2 AVPR1A GPR68 GPR65 AVP CHRM5 PMCH TSHB GHSR DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 MUCOPOLYSACCHARIDOSES%REACTOME DATABASE ID RELEASE 97%2206281 Mucopolysaccharidoses SGSH GNS NAGLU GLB1 HYAL1 IDS GALNS GUSB IDUA ARSB HGSNAT NEGATIVE REGULATION OF DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-9974237.1 Negative Regulation of DNA Double Strand Break Response PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 RBX1 PSMC3 PSMA1 PSMC4 PSMC1 BRCA1 UBA52 PSMD12 PSMD11 DDB1 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 CUL4A PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 BARD1 CUL4B PSMC2-1 PSMA2-1 PSMA5 SEM1 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME DATABASE ID RELEASE 97%9660537 Signaling by MRAS-complex mutants ARAF MRAS RAF1 YWHAB BRAF SHOC2 PPP1CB PPP1CC MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion ADAR ADARB1 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement C8B C8A C5 C8G CLU C6 C7 C9 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 97%74160 Gene expression (Transcription) CSNK2A1;CSNK2A3 MGLL AGPAT2 HDAC11 BMI1 YY1 RING1 MAF HDAC5 HDAC9 RNF2 HDAC6 HDAC7 CBX8 GPAM CBX6 PHC2 PHC1 POU2F1 CBX4 CBX2 NFATC2 LPIN1 POU2F2 PHC3 PNPLA2 NFYA-1 ERBB2 EGFR YWHAE PRKACA-1 LBR PPP2R1A YWHAG SKP1 HSP90AA1 TCF7 CDC73 LEO1 AJUBA UBA52 CUL1 AURKA CCNB1 RPS27A UBB;UBC MEF2C CENPJ SPI1 TGIF1-1 CDK1 ZNF287 ZNF18 RBFOX1 RBFOX3 BCL2L11 TXN ZNF282 ZNF10 ZNF12 CLDN5 PMAIP1 DDIT3 ZNF23 BID ZNF25 BBC3 GRIN2A ZNF268 ZNF263 ABCA6 NR2F1 NR0B2 GRIN2B NR2F6 COL1A1 INS;INS-IGF2 COL1A2 ZNF496 ZNF250 UCMA ZNF45 HEY1 HEY2 ZNF41 CTLA4 ZNF248 ZNF485 ZNF483 ZNF235 SLBP ZNF473 SERPINB13 ZNF470 HTT ZNF226 ZNF222 CR1L;CR1 ATAD2 ZNF77 ZNF79 SKI ZNF70 AGRP ZNF215 ZNF214 ZNF213 ZNF697 ZNF696 ZNF212 ZKSCAN4;ZKSCAN3 ZNF692 ZNF691 NFYB RORC RORB NFYC ZNF689 ZNF205 ZNF446 ZNF688 ZNF445 PITX2 ZNF202 ZNF200 ZNF160;ZNF347;ZNF665-1 ZFP69B CTSK FOXP3 NPAS4 ZNF432 PVALB BLK GRIA2 MAX DLX6 FOXO4 FOXO3 CTSV;CTSL ATXN3 ZKSCAN8 ZNF668 ZNF667 ZKSCAN5 ZNF664 SOCS4 ZKSCAN1 ZNF662 ZNF660 FBXO32 ZNF419 MMP13 ZNF658 ZNF416 ZNF655 SP7 ITGAL DGCR8 YAF2 NKX3-2 ZNF641 TRIM63 ITGA4 TNFRSF18 FURIN ZKSCAN7;ZNF852 PPM1A HAND2 ITGA5 SPP1 PPM1D YAP1-1 ZNF624 ZNF621 E2F5 E2F6 ZNF747;ZNF764 MGA TBX5 PINK1 SST SYT10 IL2RA ZNF615 ZNF614 RB1 ZNF613 SMARCB1 STUB1 CCNH EHMT2 PTPN4 EHMT1 TRIM33 UXT RRP8 LIPE LGALS3 CCN2 H2AC14 TRIM28 ZFP1 ZNF713 SAP130 ZNF711 DPF1 ZNF710 PDK4 L3MBTL2 DPF2 FOXG1 DPF3 TGFA KAT8 ZNF707 MED1 SAP30BP ZNF706 SMARCC1 ZNF704 SMARCC2 ZNF703 HIVEP3 ACSL1 WWTR1 HCFC2 YES1 MED4 IQSEC3 MED6 ITGBL1 MED7 MSTN HCFC1 HNF4G WDR82 PAXIP1 FOXO1-1 PEX11A SATB2 BAZ2A ZFP14 RXRG ZNF454;LOC100996598;HMGA2;LOC105371063;ZNF875 CCNC-1 GAD1 GAD2 OGT-1 VEGFA H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A CCNG2 PPARGC1B ZFP28 CREBBP IHH ZNF274;ZNF74 ZNF382 CCND3 SETDB1 CCND2 SS18L1 NPPA SETD1B MSX2 SETD1A SMARCA5 GEM SMARCA2 GPRIN1 SMAD2;SMAD3 CIDEC SMARCA4 ZFHX3 AUTS2 TADA2A IL2 ZZZ3 IL3 H2AC20 ZNF30 BMP2 LDB1 H2AB2;H2AB3;H2AB1 EZH1 MYBL2 EZH2 RBM14 CBX3-1 TGIF2 ELF1 PHF20 SUV39H1 ELF2 CAT PHF1 RETN ASH2L ZNF804B SGF29 MED16 ZNF175 MED17 SERPINE1 MED12 JUNB MED14 RNF111 MED13 ZSCAN25 MED10 ZNF157 CD36 ZNF398 ZNF394 JARID2 NCOA1 NKX2-5 BCDIN3D NCOA2 NR2C2AP SS18 TARBP2 ZNF383 NCOA6 ZNF140 PRKRA ELOVL5 CDC7 XPO5 NCOA3 DROSHA NR1D2 ACTL6A ZNF699-7 ZNF135 TET2 ZNF133 TET1 RARG PPHLN1 MED27 BTG1 BAZ1B ZNF568-3 SIRT1 UBE2D3-1 MED23 RSPO3 PHF20L1 TEAD1 TEAD2 NCOR2 PIWIL2 TEAD3 KAT2B PIWIL1 ZIK1 H2AJ HENMT1 TEAD4 KAT2A NR5A2 TCF12 ASZ1 PAX5 NCOR1 MAEL MED24 TDRKH-1 TAL1 MOV10L1 AEBP2 RARB MYBL1 TET3 ZNF599 MTF2 ZNF114 TDRD9 MED20 ZNF597 TDRD6 PLIN4 ZNF112 TDRD1 PLIN2 OCLN-1 TDRD12 ANGPTL4 ZIM2 FKBP6 PLIN1 ZNF584 GPS2 ZNF583 SF3B1 PCGF6 MBD3 ZNF582 CDKN2B SUZ12 H2BC5 PCGF5 MCRS1 PCGF2 MBD2 WWP1 SIRT3 H2BC1 RYBP ZNF669;ZNF670 ZNF334 GTF2H1 ZNF573 GTF2H3 ZNF570 GTF2H4 CSF2 GATAD2B ITGA2B GATAD2A ZFP30 FABP4 ZNF569 MYBBP1A ZNF567 MED31-1 ZNF566 ZFP37 MPHOSPH8 ZNF331 ZNF565 CYCS-1 ZNF563 ARID4B TTF1 IGFBP1 EP300 PF4;PF4V1-1 MTREX ZNF302;ZNF181 PHLDA1 NRBP1 MEN1 ZNF311 BOD1L2;BOD1 ZNF793 ZNF792 H2AC4 ADIPOQ ZNF791 SAP30 KRBA1 SPOCD1 ZNF549 ZNF548 TBL1XR1 ZNF317 ZNF546 ZNF354A;ZNF354B-4 ZNF304 ZNF786 ZCCHC8 KMT2D SKIL DNMT1 PLXNA4 KMT2A ZNF300 KMT2C ZNF782 KMT2B ESRRB CRCP BOD1L1 ESRRG POLR3GL ZFP69 LPL MED30 CDK6 POLR3A ZNF777 POLR3B TASOR ABL1 ZNF775 POLR3C MBIP ZNF426-1 POLR3D ZNF774 POLR3E TASP1 ZNF772 POLR3F SUDS3 ZNF324B;ZNF324 ZNF771 POLR3G MORC2 ZNF770 POLR3H DR1 ZNF529 POLR3K ZNF521 CBX5 CDK8 ZNF75D CDK7 ZNF75A STK11 CDK5 ZFP90 YEATS2 CRH ACTB-1 ZNF514 TADA3 ZNF750 MNAT1 ZNF746 PHF19 ZNF740 GSK3B KCNIP3 PIWIL4 KLF4 AKAP8L RAD51 PSIP1 ZNF606 DPY30 ZNF605 CHD4 SOX9 CHD3 ZNF839 PAGR1 ZNF555;ZNF57;ZNF556 DNMT3L TWIST2 BCL7A CITED1 SIN3B CITED2 SIN3A CITED4 H2BC21 PARP1 BCL7C GP1BA ZNF649 ZNF3 BCL7B ZNF350;ZNF432 UBTF ZNF557;ZNF558 DNMT3B NPY WDR5 CAMK4 LMO1 RBM7 ZNF197;ZNF660-ZNF197 KDM6A TBP LMO2 EED ATP1B4 DNMT3A LIFR KCTD6 H2AZ2;H2AZ1 ZNF124-4 ARID1A COX4I1 NOP2 ARID1B COX4I2 ZNF264;ZNF805-1 SMAD1 POLR1A SMAD4 POLR1B SMURF2 POLR1C SMURF1 POLR1D SMAD6 POLR1E ESR2 POLR1F SMAD7 POLR1G NR4A1 POLR1H NR4A3 C19orf84 THRA ARNT SMARCD1 NR2E1 CEBPA YBX1 GTF2H2C;GTF2H2C_2;GTF2H2 OPRM1 SMARCD2 CAMK2B ACSS3 CAMK2D HDAC2 CAMK2A SMARCD3 NR2C2 HDAC3 THBS1 UHRF1 HSPD1 HDAC1 HES1 CXXC1 CAMK2G DDX21 ZNF189 TAF1D ZNF286A MTA1 ZNF184 TAF1B ZNF180 RBBP4 OPRK1 TAF1C RBBP5 SAP30L TDG TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H RBBP7 MTA2 MTA3 POLR2L SMARCE1 ATF7IP DEK EPOP H2BC15;H2BC3;H2BC11;H2BC12 KANSL1 ERCC3 KANSL2 SCD KANSL3 ERCC2 THRSP ERCC6 NDUFA4 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 RXRB ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 G6PD YWHAB XPO1 AKT1 YWHAZ MAPK14 MAPK11 GLI3 GLI2 RBX1 ANG ITCH PIP4K2A PIP4K2B PIP4K2C MED8 CCNK CCNT1 GTF2B SUPT16H GTF2F1 GTF2F2 NEDD4L GTF2E1 GTF2E2 PIP4P1 SUPT4H1-1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 TAF4B RRM2-1 ELL ELOC-1 TAF7L ELOA NELFB ELOB NELFCD NELFA NELFE NCBP1 GTF2A1 GTF2A2 CTDP1 RNMT TAF9 POLR2A POLR2B POLR2C POLR2D POLR2G TAF9B POLR2I TAF15 RNGTT TAF12 TAF13 TAF10 TAF11 SSRP1 NCBP2-1 TAF8 TCEA1 ESRRA TAF7 TAF6 TAF5 TAF4 TAF3 RAN TAF2 TAF1 GLS2 TXNRD1 FKBP5 PPP2CB;PPP2CA AXIN1 PPP2R5C PPP2R1B MTERF1-1 RET TFB2M GATA3 TFAM-1 POLRMT HNF4A JAG1 PRDM1 MYC COX7A2L-1 ARNTL TNRC6C MOV10 ARNT2 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B BRD2 TGFB1 CCND1 CBFB KRAS RUNX3 RUNX1 COX7A2 TFAP2A WWOX TFAP2C TFAP2D KCTD1 TFAP2E;TFAP2B KCTD15 CSF1R CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 CDC27 TCF7L2 ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 EAF1 EAF2 RRN3 AKT2 AKT3 SNRPD3 SUPT6H AFF4 POMC SNRPE-2 SFN MLLT1 MLLT3 NLRC4 IWS1 CASP1 TXNIP SKP2 PRMT1 MET TCF7L1 DLX5 SOX2 MYB TSC2 TSC1 STAT1 TJP1 ZFPM1 GATA4 GATA2 GATA1 NFE2 SNRPF SNRPB IRAK1 CAV1 YWHAQ YWHAH PDPK1 SNRPG-2 DICER1 PTPN11 CALM3;CALM1 PABPN1-1 SOD2 IFNG CCNE2 CCNE1 PLK2 MDC1 ATF2 TP53RK NOC2L SGK1-1 KAT5 CHEK2 CHEK1 TP63 DAXX HUS1 PRKAB1 RRAGA RRAGC RRAGB DDIT4 RRAGD DNA2 MAML2 RHNO1 MAML1 E2F4-1 L3MBTL1 MEAF6 MAPKAP1 PRDX2 TFDP1 NUAK1 PCBP4 PRDX1 TFDP2 TP53BP2 ATRIP MAML3 PRELID3A NOTCH2 NOTCH3 BANP BARD1 NOTCH4 PLK3 PRELID1 E2F1 CRADD GADD45A TPX2 RAD17 JUN ATM SNW1 CDK12 MAMLD1 CDK13 ATR TP73 CDKN1A BTG2 CDKN1B SETD9 PRKAG1 CHM BRCA1 PRKAG3 RPTOR ING5 ING2 AIFM2 CASP10 TNKS1BP1 PRMT5 BRD1 RMI2 CNOT6L RMI1 TOP3A FOS DDB2 RAD51D BRPF3-1 PCNA WRN PLAGL1 PERP PMS2 SOCS3 RICTOR BRD7 PTPN1 TIGAR RPA1 RPA2 BRF2 CDK4 MLH1 BDP1 HIPK1 CDK2 POU4F1 POU4F2 HIPK2 TTC5 RPA3 CCNG1 RAD1 LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 STEAP3 MRE11 SESN3 SESN2 KMT5A NBN BNIP3L USP7 IGFBP3 USP2 CDC25C MSH2 FANCD2 KAT6A MAPKAPK5 SMYD2-1 BLM MDM2-2 NDRG1 NPM1-2 SLC38A9 BCL2L14 ZNF420 MAP2K6 FANCI BRPF1 CNOT10 FANCC CNOT4 CNOT6 RGCC TP53I3 CNOT7 BCL6 CNOT11 RHEB CNOT1 CNOT2 JMY CNOT3 PIN1 MDM4 RAD9B CNOT8 CNOT9 RAD9A PRR5 DYRK2 PPP1R13B PIDD1 EXO1 PHF6 CASP6 PPP1R13L MLST8 CASP2 TOPBP1 ZNF385A RFC5 RFC3 RFC4 APAF1 RFC2 RABGGTB RABGGTA RBL2 RBL1 BIRC5 TMEM219 PRKAA1 TRPC3 RNF34 AURKB TP53INP1 RBBP8 RFFL E2F7 E2F8 ARID3A PML MTOR RAD50 BAX HDAC10 FASLG EPC1 PRDM7;PRDM9 FAS TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A SSB NFIX PRKCQ NFIA NFIB IPO8 NFIC PRMT6 PBRM1 ACTL6B BDNF CDK5R1 GCK YEATS4 MAPK1 MAPK3 ARID2 CCNA2-1 CCNA1 KDM5B PRKAB2 HDAC8 SCO2 REST DDX4 PRKAG2 MED15 TSNAX MED26 TSN MED25 KIT PPARD GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 BRF1 GTF3A GTF3C6-1 PRKCB RAMAC LSM10 LSM11 NABP1-1 INTS1 INTS3 INTS2 INTS5 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 ICE1 ICE2 SSU72 NABP2 PHAX ZNF143 G6PC1 ELL2 ELL3 ZC3H8 RPRD2 RPAP2 SP1 RPRD1B RPRD1A SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 PTEN CPSF2-1 NUDT21 RRM2B USP9X PRKAA2 BRIP1 WDR61 APOE PCK1 WDR33 PAPOLA FIP1L1 COX7B COX7C COX8A SREBF1 COX8C CSTF3 CSTF2 SRC SRF COX5B COX5A COX6C CPSF4 CPSF1 CPSF3 COX6A1 COX6A2 COX6B2 COX6B1 SRRT CTR9 RTF1 SYMPK PAF1 CAVIN1 HDAC4 UBE2I THRB VDR NR1H2 RORA NR3C1 ESR1 NR2C1 NR4A2 NR5A1 AR RXRA SUMO1 SUMO2 RARA CARM1 PGR PPARG PPARA CSTF2T TP53 GLS NAMPT GAMT CLP1 DGAT2 CSNK2A2 CGA NR1D1 CSNK2B CPSF7 PLD6 GPI PCF11 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.5 Activation of BIM and translocation to mitochondria BCL2L11 MAPK8 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112412 SOS-mediated signalling SOS1 IRS1 HRAS IRS2 NRAS AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 97%156587 Amino Acid conjugation ACSM1 GLYATL3 ACSM5 ACSM4 ACSM2A;ACSM2B GLYAT BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9912481 Branched-chain ketoacid dehydrogenase kinase deficiency DLD BCKDHA DBT BCKDHB BCKDK REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 97%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation UBB;UBC TBK1 TANK TLR3 IKBKE TICAM1 OPTN-1 TRAF3 RPS27A UBA52 KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 97%9664420 Killing mechanisms JUN WNT5A CYBA NOXO1 MAPK8 DVL1 RAC1 NOX1 NOXA1 FZD7 DVL2 DVL3 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 97%9702636 tandutinib-resistant FLT3 mutants FLT3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida ZP1 ZP2 ZP4 ADAM21 ADAM20 ADAM30 ADAM2 B4GALT1 SPAM1 ZP3;POMZP3 OVGP1 MMR%REACTOME DATABASE ID RELEASE 97%5358508 MMR MSH2 PMS2 RPA1 RPA2 MLH1 EXO1 POLD3 POLD4 RPA3 POLD2 LIG1 MSH6 MSH3 POLD1 PCNA BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) ALOX5AP ALOX15 ALOX12 HPGD LTA4H PTGS2-2 GSTM4 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 EPHX2 LTC4S ALOX5 CYP1A1 CYP1A2 PTGR1-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5602498 MyD88 deficiency (TLR2 4) S100A8 FGG TLR2 MYD88 LY96 BTK TLR6 S100A1 CD14 HMGB1-1 TIRAP TLR4 CD36 TLR1 FGB FGA S100A9 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand TLR7 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) ACTL6A DPF1 DPF2 DPF3 SMARCC1 SMARCC2 ACTB-1 SMARCE1 BCL7A SS18L1 BCL7C ACTL6B BCL7B SMARCA2 SMARCA4 BCL11A ARID1A ARID1B SMARCD1 SMARCB1 BCL11B SMARCD2 PHF10 SS18 SMARCD3 RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling PSPN FRS2 GAB1 GFRA2 SOS1 GFRA4 PIK3CA PTPN11 ARTN MAPK7 GRB10 PIK3R3 RET GAB2 GRB7 DOK2 DOK1 SHC1-1 GFRA3 IRS2 PRKACB-1 DOK4 DOK5 GFRA1 DOK6 PRKCA GDNF SHC3 RAP1GAP PIK3CD SHANK3 PIK3R2 PIK3CB PLCG1 PDLIM7 PIK3R1 NRTN PRKACA-1 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME%R-HSA-5619083.3 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9640463 Wax biosynthesis FAR1 AWAT2 FAR2 AWAT1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 97%913709 O-linked glycosylation of mucins C1GALT1C1 GCNT3 GCNT4 GALNT7 GALNT6 GALNT5 GALNT4 MUC12 A4GNT MUC15 B4GALT6 MUC3A MUC5AC B4GALT5 ST6GAL1 MUC1 MUC2 MUC7 MUC4 MUC6 GALNT3 ST3GAL4 MUC17 ST6GALNAC2 C1GALT1 MUC5B ST3GAL1 MUC20 ST3GAL2 MUC21 ST3GAL3 B3GNT7 B3GNT5 B3GNT4 B3GNT3 ST6GALNAC3 B3GNT2 ST6GALNAC4 MUC13 GALNT2 GALNT1 GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT10 GALNT9;GALNT17 GALNTL5 GALNTL6 B3GNTL1 GALNT9 GALNT8 B3GNT9 B3GNT8 B3GNT6 CHST4 GCNT1 PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.5 Phase 3 - rapid repolarisation KCNE2 KCNE3 KCNE4 KCNE5 KCNQ1 KCNA5 KCNH2 KCNE1;KCNE1B AKAP9-1 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME DATABASE ID RELEASE 97%9833109 Evasion by RSV of host interferon responses IFNB1-4 TYK2 STAT2 RBX1 IFNAR1 IRF3 EP300 DDX58 RPS27A UBB;UBC EIF2AK2 ELOC-1 IFIH1 TRIM25 MAVS JAK1 ELOB CREBBP CUL5 UBA52 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%8866907 Activation of the TFAP2 (AP-2) family of transcription factors YEATS4 TFAP2A WWOX CREBBP TFAP2C CITED1 TFAP2D CITED2 EP300 CITED4 TFAP2E;TFAP2B EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 97%9914274 3-methylglutaconic aciduria AUH DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 97%5083630 Defective LFNG causes SCDO3 NOTCH1 NOTCH2 NOTCH3 LFNG NOTCH4 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.3 FCERI mediated Ca+2 mobilization SOS1 GRAP2 PLCG2 BTK LCP2 CALM3;CALM1 LYN TXK NFATC3 ITPR1 ITPR2 ITK ITPR3 PPP3R1 VAV3 NFATC2 NFATC1 AHCYL1 SYK PPP3CA PPP3CB PLCG1 VAV1 VAV2 TEC FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 97%444473 Formyl peptide receptors bind formyl peptides and many other ligands FPR2 APP SAA2;SAA1 ANXA1 HEBP1 FPR1 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 97%8854521 Interaction between PHLDA1 and AURKA AURKA PHLDA1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation NDUFAB1 HADH HADHA ACAA2 MCAT PCCA PCCB ACOT11 ACOT12 ACOT13 ECI1 ACBD7 ACBD6 ACSM3 THEM5 THEM4 MCEE ACSF2 MMAA ACADL ACADVL MMUT ACADM ECHS1 ACADS ACOT9 HADHB-1 ACOT2;ACOT1 MECR ACOT7 PCTP ACAD11 ACAD10 DECR1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169091 Activation of NF-kappaB in B cells PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 NFKBIB BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 CHUK REL FBXW11 NFKBIE IKBKB CARD11 BCL10 IKBKG MALT1 UBA52 NFKBIA CUL1 RELA RPS27A UBB;UBC NFKB1 MAP3K7 PRKCB GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA PIWIL4 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B ANG POLR2C POLR2D H2BC21 POLR2G POLR2I H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 RAN DDX4 BCDIN3D TARBP2 PRKRA XPO5 DROSHA DICER1 TNRC6C TNRC6A-1 AGO4 AGO2 PIWIL2 AGO3;AGO1 PIWIL1 H2AJ TNRC6B HENMT1 HSP90AA1 ASZ1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 MAEL POLR2E TSNAX TDRKH-1 TSN POLR2F MOV10L1 MYBL1 POLR2H TDRD9 TDRD6 TDRD1 POLR2L TDRD12 IPO8 FKBP6 PLD6 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 DGCR8 H2BC1 POLR2J;POLR2J2;POLR2J3 H2AC4 H2AC14 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME DATABASE ID RELEASE 97%4755583 Defective DOLK causes CDG-1m DOLK ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.4 Acyl chain remodelling of PI MBOAT7 PLA2G4A PLAAT3 PLA2G1B PLBD1 PLA2R1 PLA2G5 PLA2G2A-1 PLA2G10;LOC100652777 PLA2G2F PLA2G12A PLA2G4F PLA2G2D PLA2G2E PLA2G4D PLA2G4E IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-HSA-9732724.1 IFNG signaling activates MAPKs RAF1 IFNGR1 MAPK1 IFNGR2 JAK1 MAPK3 IFNG JAK2 STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%390522 Striated Muscle Contraction TMOD2 TTN-1 DMD TMOD3 NEB MYH3 VIM MYH8 MYH6 TNNI1 TNNI2 TNNI3 ACTN2 DES ACTN3 MYL4 MYL1 MYL2 MYL3 TPM4 TPM3 MYBPC3 MYBPC1 MYBPC2 TNNC1 TNNC2 TNNT1 TNNT2 TNNT3 TCAP TMOD1 TMOD4 TPM2 TPM1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 97%5632928 Defective Mismatch Repair Associated With MSH2 MSH2 MSH6 MSH3 GSD IV%REACTOME DATABASE ID RELEASE 97%3878781 GSD IV GBE1 GYG2 GYS2 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 97%162791 Attachment of GPI anchor to uPAR PIGS PIGU PGAP1 PIGT PLAUR GPAA1 PIGK CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport SLC5A10 SLC45A3 SLC2A10 MFSD4B-2 SLC2A4 SLC2A6 SLC2A7 SLC2A1 SLC2A2 SLC50A1 FGF21 SLC2A9 SLC5A9 SLC5A2 SLC5A4 SLC2A11 SLC2A8 SLC5A1-1 SLC2A12 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling LPL MTTP P4HB APOB APOA2 APOA1 APOA4 PCSK5 LMF2 LMF1 MBTPS1 APOA5 LIPC CREB3L3 ANGPTL8 PCSK6 ANGPTL3 FGF21 MBTPS2 ANGPTL4 APOC3 APOC2 FURIN APOF LIPG LCAT ALB CETP ABCG1 APOE GPIHBP1 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 97%68882 Mitotic Anaphase BUB1 CLASP2 BUB1B CDC20 PPP1CC BUB3 MAD2L1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 RPS27 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 MAPRE1-1 PSMA5 SEM1 PSMA6 TUBA1A PSMC5 PPP2R1A PSMA3 LBR PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 LEMD3 CKAP5 TUBA4A XPO1 UBA52 PAFAH1B1 TNPO1 DYNC1I2 CCNB2 CCNB1 ANKLE2 RPS27A CLASP1 UBB;UBC DYNC1H1 NDE1 PLK1 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 CDK1 DYNC1LI1 DYNC1LI2 KIF18A CENPN-2 MIS12-1 CDCA8 SKA1 SKA2 IST1 SPAST CC2D1B NUF2 KIF2A EMD NUDC KIF2C KIF2B INCENP CENPA CENPE CENPC CENPT NUP107 CENPU NUP188 RCC1 BANF1 CENPF CENPH CENPI NUP93 TAOK1 CHMP4C CENPK CHMP4B CHMP4A LMNB1 CENPL NUP205 CENPM CENPO PPP2R2A;PPP2R2D CENPP NUP160 NUP85 CENPQ TUBA1C TUBB1 NUP155 CHMP2B CHMP2A TUBB2B;TUBB2A CLIP1 MAD1L1 NUP62 NDC1 SEC13 TUBB3;TUBB6 TUBAL3 NUP133 NDC80 RANGAP1 POM121;POM121C CHMP3 NUP54 CHMP6 CHMP7 TUBA3E;TUBA3C-1 VPS4A SPDL1 NUP43 RANBP2 TUBA8 NSL1 NUP35 RAN NUP37 KNL1 ZW10 CDCA5 PDS5B PDS5A WAPL ESPL1 DSN1 RCC2 ZWINT AHCTF1 PPP2CB;PPP2CA PTTG1;PTTG2 PPP2R5B NDEL1 PPP2R5A PPP2R5D PPP2R5C PPP2R1B PPP2R5E VRK1 LEMD2 DYNC1I1 KPNB1 UBE2I B9D2 SPC24 SPC25 ERCC6L SUMO1 ZWILCH SIRT2 PMF1;PMF1-BGLAP KNTC1 BIRC5 SGO1 SMC3 SGO2 AURKB RAD21 CENPS-CORT;CORT;CENPS STAG1 STAG2 SMC1A ANAPC15 ANAPC16 UBE2D1 ANAPC10 ANAPC11 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ITGB3BP NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPS14 NCBP1 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 GSPT2 RPL10A GSPT1 RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 ETF1 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 UPF1 RPS4X RPL35 RPL38 RPS3A RPL10;RPL10L-1 NCBP2-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 EIF4G1 RPSA RPL17 RPL19 RPS15 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375276 Peptide ligand-binding receptors AGT NTS MCHR2 TAC3 TAC1 NMUR2 NMUR1 AVPR2 MLNR TRH CXCR4 BDKRB2 BDKRB1 CCL3L1;CCL3L3;CCL3;CCL18 POMC APP CCK KISS1 MCHR1 PSAP RXFP4 MRGPRD CXCL9 RXFP1 CXCL8 CXCL13 RXFP2 RXFP3 CX3CL1 CCRL2 CCR9 CXCL5;CXCL6 AGTR2 CCR8 FPR1 CCR7 SSTR3 CCR4 GALR3 CCR3 GALR2 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 GALR1 NPBWR1 CCL11 NPBWR2 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 CCL5 PNOC MC4R CXCR2 CCL1 EDNRB CCL19 CCL17 CCR10 EDN1 CCL16 CCR1 EDN3 GPR37 CCL25 CCL22 CCL21 C5AR2 CCL20 PPBP MC3R C5AR1 CXCL10 CXCL11 ACKR4 MC1R ACKR2 MC5R CCL28 CCL27 C5 ACKR3-2 NPFFR2 NPFFR1 NPFF PF4;PF4V1-1 HCRT QRFPR QRFP HCRTR2 HCRTR1 RLN3 ECE1 PRLHR INSL3 INSL5 APLN ECE2;EEF1AKMT4-ECE2 GPR37L1 KEL NLN PENK PPY NPY4R2;NPY4R GAL OPRD1 NPB NPW RLN2;RLN1 PRLH MAS1 XK PDYN NPY2R NPY NPY1R APLNR C3AR1 OXTR GRPR EDNRA PYY PROK2 PROK1 UTS2R TRHR OPRM1 UTS2B HEBP1 AGTR1 CENPS-CORT;CORT;CENPS CXCL12 GPER1 FPR2 NTSR1 C3-1 NTSR2 SAA2;SAA1 NMB NPY5R XCR1 OPRK1 XCL1;XCL2 NMBR SSTR1 SSTR2 NMS SSTR4 NMU SSTR5 MLN OPRL1 MC2R BRS3 CCKAR EDN2 ANXA1 TACR2 TACR3 ACKR1 TACR1 CCKBR CX3CR1 NPSR1 F2R GRP F2 NPS PROKR1 PROKR2 KISS1R OXT-1 KNG1 F2RL1 F2RL2 CCR6 F2RL3 AVPR1B CCR2 AVPR1A SST AVP PMCH CCR5 GHSR STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 97%1834941 STING mediated induction of host immune responses XRCC6 TBK1 STAT6 PRKDC XRCC5 CGAS STING1 TRIM21 IRF3 IFI16 NLRP4 MRE11 TREX1 DDX41 DTX4 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4551638 SUMOylation of chromatin organization proteins NUP133 L3MBTL2 NUP50 POM121;POM121C CBX5 NUP54 BMI1 SATB2 HDAC4 RING1 NUP42 UBE2I CHD3 SATB1 NUP43 PIAS1 RNF2 RAE1 RANBP2 CBX8 SUMO1 SUMO3 SUMO2 PHC2 PHC1 CBX4 CBX2 PHC3 NUP35 NUP37 HDAC2 HDAC1 ZBED1 NUP107 NUP188 NUP210 NUP93 NUP205 AAAS SUZ12 PCGF2 NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 NUP62 NDC1 SEC13 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome HSP90AB1 TXN APP RELA MEFV NFKB2 HMOX1 PANX1 PYCARD P2RX7 PSTPIP1 CASP1 TXNIP SUGT1 NFKB1 NLRP3 MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 97%2206290 MPS IV - Morquio syndrome A GALNS TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME DATABASE ID RELEASE 97%9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 HDAC1 MTA1 RBBP4 EBF2 RBBP7 PRDM16 MTA2 MTA3 CIDEA ELOVL3 BMP7 CHD4 CHD3 PPARGC1A PPARGC1B MBD3 GATAD2B RXRA GATAD2A UCP1 PPARG PPARA HNRNPU SMAD1 SMAD4 ZNF423 NCOA1 HDAC2 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 97%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9709275 Impaired BRCA2 translocation to the nucleus BRCA2 SEM1 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 97%5579014 Defective CYP27B1 causes VDDR1A CYP27B1 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex NCBP1 CDK7 POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H POLR2J;POLR2J2;POLR2J3 NCBP2-1 NELFB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT KIT BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs ALOX12 ALOX15 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%R-HSA-164939.5 Nef mediated downregulation of CD28 cell surface expression CD28 VISUAL PHOTOTRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2187338 Visual phototransduction LPL METAP1 GNAT1 METAP2 AKR1B15;AKR1B10 APOB RBP3 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW LRAT AWAT2 SDC4 RBP4 SDC2 DHRS3 SDC3 RBP2 GNB1 RBP1 SAG DHRS9 HSPG2 RDH10 RDH12 RETSAT RDH11 RPE65 LOC118142757;GUCA1A SDC1 RDH8 FNTA HSD17B1 PDE6B PDE6A PLB1 CLPS OPN1SW RLBP1 GUCA1C GPIHBP1 MYO7A FNTB;CHURC1-FNTB APOA2 APOA1 APOA4 PPEF1 PNLIP GUCY2D LRP1 HSD17B6 CALM3;CALM1 TTR BCO2 PRKCQ CNGB1 LRP2 BCO1 GPC1 STRA6 LRP8 GPC3 APOC3 RHO GPC2 GPC5 CNGA1 GPC4 ABCA4 SDR9C7 SLC24A1 APOC2 GNGT1 GPC6 PRKCA CAMKMT RGS9BP LRP10 AGRN LRP12 NMT1 NMT2 RDH5 APOM CYP4V2 GRK1 GRK7 LDLR APOE RCVRN DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ ABCD4 LMBRD1 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9035034 RHOF GTPase cycle ADD3 SRGAP2 BAIAP2L2 TOR1AIP1 BAIAP2L1 FARP1 ARHGAP12 TMPO ACTN1 SLC4A7 VANGL1 ACTB-1 DEPDC1B SNAP23 RAB7A CAPZB LMNB1 MCAM CAV1 MYO9B DIAPH1 ARHGAP32 DIAPH2 DIAPH3 ESYT1 ARHGAP1 SOWAHC AKAP12 MTMR1 ARHGAP39 SYDE1 BASP1 RHOF VAMP3 PIK3R2 SENP1 STEAP3 PIK3R1 ARHGAP5 ARHGAP21 FAM169A LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 97%9022538 Loss of MECP2 binding ability to 5mC-DNA HDAC1 SIN3A TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%9843743 Transcriptional regulation of brown and beige adipocyte differentiation HDAC1 MTA1 RBBP4 EBF2 RBBP7 PRDM16 MTA2 MTA3 CIDEA ELOVL3 BMP7 CHD4 CHD3 PPARGC1A PPARGC1B MBD3 GATAD2B RXRA GATAD2A UCP1 PPARG PPARA HNRNPU SMAD1 SMAD4 ZNF423 NCOA1 HDAC2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 97%453274 Mitotic G2-G2 M phases FBXL18 CCNA2-1 TUBG2 CCNA1 NME7 TUBGCP2 MZT2A;MZT2B MZT1 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 PSMD12 PSMD11 PSMD14 CDC25A PSMD13 HMMR CDC25B PSMA7 PSMD8 MYBL2 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 YWHAE CEP57 CETN2 ADRM1 CEP164 CCP110 AKAP9-1 PSMC2-1 PPP1CB E2F1 PSMA2-1 MAPRE1-1 PSMA5 E2F3 SEM1 TPX2 PRKACA-1 ACTR1A PSMA6 TUBA1A PSMC5 PPP2R1A PSMA3 CNTRL PSMC6 CEP250 PSMA4 NEK2 BTRC CDKN1A PSMC3 CEP290 PSMA1 YWHAG PSMC4 RAB8A PSMC1 SKP1 CDK5RAP2 HSP90AA1 OPTN-1 HJURP CEP135 PPP1R12A BORA MIS18BP1 FBXW11 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 TUBG1 CKAP5 HAUS2 TUBA4A HAUS1 XPO1 CEP63 AJUBA UBA52 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 CDK2 HAUS8 PRKAR2B PPP2CB;PPP2CA HAUS7 CEP70 CEP72 EP300 CEP192 RPS27A PHLDA1 PCNT PPP2R1B OBI1 CEP76 LCMT1 CLASP1 PPME1 UBB;UBC CEP78 TICRR PLK4 OFD1-1 FOXM1 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B NEDD1 CDK11A;CDK11B TUBB4A;TUBB;TUBB8B;TUBB8 CENPJ CDC25C ALMS1 CDK1 TPTEP2-CSNK1E;CSNK1E FBXL7 CEP41 CEP43 RBX1 CDK7 GTSE1 FKBPL MNAT1 PPP2R3B HSP90AB1 PKMYT1 TP53 WEE1 SGO1 RBBP4 CENPF LIN54 LIN37 LIN9 LIN52 PPP2R2A;PPP2R2D FZR1 CCNH PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 97%111995 phospho-PLA2 pathway PLA2G4A MAPK1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade METAP1 GNAT1 METAP2 FNTB;CHURC1-FNTB GUCY2D PPEF1 CALM3;CALM1 PRKCQ CNGB1 RHO GNB1 CNGA1 SAG GNGT1 PRKCA CAMKMT RGS9BP NMT1 LOC118142757;GUCA1A NMT2 GRK1 FNTA PDE6B GRK7 PDE6A RCVRN GUCA1C BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210991 Basigin interactions ITGB1 SLC16A8 SLC16A3 ITGA6 ATP1B2 ATP1B1 SLC7A6 SPN SLC7A7 MMP1 SLC7A8 SLC7A9 SLC7A5 MAG SLC3A2 BSG CAV1 ATP1B3-1 PPIL2 ITGA3 SLC16A1 L1CAM PPIA SLC7A11 SLC7A10 HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis COX15 ALAS2 ALAS1 CPOX ALAD ALB COX10 UROS PPOX ABCG2 UROD HMBS FECH HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME%R-HSA-9856530.2 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells RAMP2 GNG10 GNAS-1 GNG2 ADCY9 GNG5 NOS3 GNG4 PRKAR1B GNA11 PRKAR1A GNG8 ADCY4 ADCY3 CAPNS1 ADCY2 ADCY1 CAPNS2 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 CAPN2 PRKACB-1 GNAQ GNB2 PRKAR2A GNB1 ADM GNB4 VCL GNB3 P2RY2 PRR5 GNB5 TLN1 CDH5 PDPK1 PANX1 CALCRL MLST8 PIK3CD MAPKAP1 PIK3R2 PIK3CB PECAM1 FYN PRKACA-1 PIK3CA MTOR TRPV4 KDR CTNNB1 CALM3;CALM1 MMP14 PKN2 AKT1 GNGT1 RICTOR PRKAR2B FLT4 PIEZO1 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation AMT DDO DLD GNMT GRHPR GOT2-1 DAO ALDH4A1 PXMP2 MRPS36 DLST GCSH-3 OGDH AGXT2 PRODH2 HOGA1 GLDC AGXT HAO1 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%8856828 Clathrin-mediated endocytosis ARPC4 IGF2R ARPC5 NECAP1 TGFA COPS4 APOB ARPC2 ARPC3 RAB5B COPS2 AVPR2 CD4 ACTR2 CHRM2 WNT5A ADRB2 WASL GRK2 HIP1 FZD4 M6PR SYNJ2 CLTB SCARB2 PIP5K1C ARRB2 AGFG1 SYNJ1 EGF STON1-GTF2A1L ARF6 KIAA0319 RAB5A TOR1A EGFR TOR1B SYT9 SYT8 DAB2 IL7R CLTCL1 SNAP91 STON2 EPS15L1 PIK3C2A SLC2A8 EPN1 SLC18A3 SGIP1 EPN2 VAMP4 FCHO1 FCHO2 UBQLN1 REPS2 AREG REPS1 UBQLN2 EPS15 NECAP2 SYT11 CFTR EREG BTC STAM HBEGF PICALM CLTC CLTA UBA52 AP2A1 AP2B1 CBL AP2A2 SYT1 DNM1 DNM2 VAMP2 DNM3 AP2S1 SH3GL2 ITSN2 RPS27A TFRC UBB;UBC ITSN1 HSPA8 FNBP1L CTTN FNBP1 TF BIN1 SNX18-1 AMPH PACSIN2 PACSIN3 PACSIN1 SH3GL3 SH3GL1 TRIP10 ARPC1A CD3D GRK3 CD3G VAMP3 GPS1 AGTR1 STAM2 HGS OCRL LRP2 TACR1 EPGN ARRB1 SYT2 ACTR3-1 LDLRAP1 COPS7B COPS7A VAMP7 VAMP8 SH3KBP1 GAK DNAJC6 RAB5C TGOLN2 COPS3 COPS6 COPS5 ARFGAP1 SNX9 AVP LDLR GAPVD1 COPS8 DVL2 HIP1R TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 97%8986944 Transcriptional Regulation by MECP2 RBFOX1 FOXG1 GRIN2A CRH IRAK1 GRIN2B GAD1 GAD2 SIN3A SGK1-1 GPRIN1 HTT CAMK4 DLL1 PTEN PPARG GAMT TRPC3 OPRM1 CAMK2B AURKB CAMK2D HDAC2 CAMK2A PRKACA-1 HDAC3 HDAC1 LBR MET CAMK2G TNRC6C MOV10 TNRC6A-1 PVALB OPRK1 AGO4 AGO2 NCOR2 GRIA2 AGO3;AGO1 TNRC6B NCOR1 CALM3;CALM1 GPS2 SOX2 FKBP5 DGCR8 BDNF PTPN1 HIPK2 SST TBL1XR1 MEF2C PTPN4 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation MAPK14 PRKAB1 PRKAB2 PRKAA2 MAPK11 PRKAG1 PPARGC1A MAPK12 PRKAG3 PRKAG2 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%112316 Neuronal System ABCC8 STX1A ABCC9 GJC1 KCNK10 PTPRF GJA10 KCNJ14 KCNK13 PRKAB2 KCNK16 GRM1 KCNK18-1 GJD2 GRM5 KCNK17 KCNK2 CACNA2D2 KCNK4 BCHE SLC6A4 PANX1 GRIA1 GRIP1 EPB41L1 TSPAN7 GRIA3 GRIA4 NSF GRIP2 DLG1 PICK1 KCNK6 KCNK7 KCNK1 KCNN1 SYT9 KCNN3 KCNN4 KCNC2 HCN4 HCN3 SLC18A3 HCN2 PRKAG2 HCN1 PRKACA-1 FLOT2 SHARPIN SLC5A7 NTRK3 UNC13B RAB3A SYT1 PRKCA SYN3 CPLX1 SYN2 KCND1 SYN1 KCND2 RIMS1 PPFIA1 PRKAR2B KCND3 PPFIA4 SLC18A2 PPFIA3 PPFIA2 PANX2 KCNB1 RPS6KA3 RPS6KA2 KPNA2 RPS6KA1 KCNG2 HSPA8 PRKCB IL1RAPL1 STXBP1 KCNMB1 KCNMB2 ARL6IP5 KCNMA1 KCNMB3 NAAA KCNMB4 ADCY9 PRKAR1B PRKAR1A GRIN2A ADCY4 LRFN3 ADCY3 LRFN2 MYO6 GRIN2B LRFN4 ADCY2 LRFN1 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PTPRD PPFIBP2 PRKAR2A SLITRK2 SLITRK1 SLITRK4 IL1RAPL2 SLITRK6 LRRC4B SNAP25 PDPK1 CAMK1 CAMKK1 CAMKK2 PPFIBP1 GNAT3 HRAS GNAI3 NRAS COMT KCNAB2 PRKAA2 GRIA2 CALM3;CALM1 TSPOAP1 RPS6KA6 CHRNB2 ACTN2 CHRNA2-1 CASK CHRNA1 CHRNB4 CHRNA9 CHRNA3 LIN7A CHRNB3 LIN7C GRIN2C CHRNA5 GRIN2D CHRNA4 GRIN3B CHRNA6 GRIN3A GNAL SLC32A1 DLG2 SLC6A13 GNGT1 DLG3 ABAT SYT2 NBEA GABRB3 SLC6A1 GABRB2 ALDH5A1 GABRB1 KCNQ1 GRIK5 RASGRF1 GRIK3 GRIK4 GRIK1 GRIK2 PLCB3 NRGN GABRR3 GABRR2 GABRR1 GABRG3;GABRG2 PLCB1 PLCB2 NPTN NEFL SLC1A1 HTR3A HTR3B LRRC7 SLC1A2 SYT10 SLC1A3 LIN7B CHRNA7;CHRFAM7A KCNA5 PPM1E PPM1F SIPA1L1 NCALD GLRA1 LRRTM3 CHRND KCNH2 CACNB1 LRRTM4 GLRA2 CACNB4 LRRTM1 CACNA2D1 GLRA3 SLC1A6 LRRTM2 CACNA2D3 DLGAP1 CHRNG HOMER3 CHRNE CACNA1B SLC1A7 DLGAP3 KCNJ2 DLGAP4 KCNJ12;KCNJ18 SHANK2 KCNJ3 GABRQ SLC38A2 SHANK1 NLGN3 KCNJ4 GABRA2 NLGN1 GNG10 GABBR2 NLGN2 KCNQ2 EPB41 GABRA1 KCNQ3 SLC38A1 NRXN3 GNG2 KCNJ5 GABBR1 NRXN2 GNG5 BEGAIN GNG4 KCNJ6 EPB41L5 KCNJ10 EPB41L2 GABRA6 GNG8 GABRA5 PDLIM5 NLGN4X;NLGN4Y KCNJ9 HOMER1 GABRA4 HOMER2 GABRA3 SYT7 KCNJ15 RASGRF2 KCNJ16 SYT12 GRIN1 APBA3 APBA2 GLRB APBA1 GAD1 GAD2 GNG13 CACNB2 CACNB3 GNB2 GNB1 PRKCG GNB4 GNB3 GNB5 PRKAB1 SRC SHANK3 SLITRK3 GNAI1 SLITRK5 GNAI2 PTPRS KIF17 KCNS3 PRKAG1 SLC22A2 GLS2 SLC22A1 RAC1 PRKAG3 NRG1 SLC17A7 KCNJ11 CACNG8 CACNG2 CACNG3 CACNG4 AP2A1 VAMP2 NRXN1;NRXN3;NRXN2 GLUL GIT1 CACNA1A SLC6A12 SLC6A11 LRTOMT CACNA1E DBNL MAOA KCNK9 KCNK3 MDM2-2 KCNJ1 KCNJ8 RTN3 CAMK4 KCNG1 KCNG3 KCNG4 GLS KCNC1 KCNA1 KCNC3 KCNA2 KCNC4 KCNA3 KCNA4 KCNA6 PRKAA1 KCNA7 KCNV1 CAMK2B KCNV2 CAMK2D KCNH1 CAMK2A KCNF1 AKAP5 KCNH3 SLC6A3 KCNH4 KCNH5 KCNH6 CAMK2G KCNH7 KCNH8 KCNB2 KCNAB1 KCNAB3 KCNS1 KCNS2 DNAJC5 KCNA10 KCNQ5 KCNQ4 CHAT KCNN2 DLG4 FLOT1 ACHE ALDH2 PRKX MAPK1 MAPK3 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.7 Translocation of ZAP-70 to Immunological synapse PTPN22 LCK HLA-DPB1-1 HLA-DQB2;HLA-DQB1 ZAP70 CD4 CD3E CD3D HLA-DPA1 HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 HLA-DRA CD3G DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 97%110357 Displacement of DNA glycosylase by APEX1 MBD4 SMUG1 NTHL1 APEX1 MPG TDG OGG1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 97%110330 Recognition and association of DNA glycosylase with site containing an affected purine NEIL3 H2AC20 ACD H2AB2;H2AB3;H2AB1 TINF2 H2AZ2;H2AZ1 H2AJ TERF2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 TERF2IP TERF1-1 H2AC4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 MPG H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 OGG1 H2BC1 H2AC14 H2BC21 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 97%193692 Regulated proteolysis of p75NTR TRAF6 PSEN2 ADAM17 NFKB1 APH1A APH1B RELA NGFR PSEN1 PSENEN NCSTN REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 97%4641263 Regulation of FZD by ubiquitination USP8 LGR5 LGR4 ZNRF3 RSPO3 FZD5 FZD4 FZD6 RPS27A FZD8 RNF43 UBB;UBC WNT3A RSPO2 RSPO1 RSPO4 LRP5 UBA52 LRP6 LGR6 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SLC12A3 SLC12A1 SLC34A2 SLC34A1 SLC26A7 SLC12A6 SLC26A9 SLC26A6 SLC4A7 SLC26A4 SLC26A3 SLC26A11 SLC12A2 SLC12A4 SLC12A5 SLC12A7 SLC5A8 SLC13A1 SLC26A2 SLC13A4 SLC26A1 SLC4A8 AHCYL2 SLC20A1 SLC4A9 SLC4A10 SLC4A2 SLC4A3 SLC4A5 SLC4A1 SLC4A4 SLC20A2 SLC5A5 SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 97%9006931 Signaling by Nuclear Receptors ABCG5 NR1H3 APOC1 PIK3R3 APOC4 AKT2 AKT3 ADH1C;ADH1B;ADH1A PTGES3-1 YY1 KDM3A KDM4A KDM4B APOD GPAM POU2F1 RDH11 EGF EGFR RXRB PRMT1 AREG HSP90AA1 PDHB TLE3 XPO1 MYB AKT1 APOC2 KDM1A PPARD PDK3 ELK1 PDK2 PDK1 PDHX KPNA2 BCL2 STRN DDX5 PRKCZ CAV1 CRABP2 CRABP1 DHRS3 DHRS4 ALDH1A3 SP1 SDR16C5 DHRS9 ALDH1A2 RDH10 RDH14 ZDHHC21 HSP90AB1 RDH13 ALDH8A1 PDPK1 GNAT3 HRAS GNAI3 PPID NRAS CCNT1 CTSD FOXO3 MMP7 GTF2F1 MMP2 CALM3;CALM1 GTF2F2 MMP3 MMP9 IGF1R UHMK1 EPGN GNGT1 CDK9 POLR2J;POLR2J2;POLR2J3 SPHK1 APOE PCK1 ALDH1A1 H2AC14 PDK4 TGFA GNG10 CYP26A1 MED1 GNG2 GNG5 NOS3 GNG4 GNG8 GTF2A1 GTF2A2 RXRG POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNG13 POLR2B POLR2C CREBBP GNB2 ATF2 POLR2D GNB1 GNB4 POLR2G KAT5 GNB3 POLR2I GNB5 H2AC20 H2AB2;H2AB3;H2AB1 SRC SRF GNAI1 GNAI2 NCOA1 NCOA2 NCOA3 ABCA1 JUN RARG CDKN1B NCOR2 KAT2B H2AJ NR5A2 NCOR1 RARB EREG BTC PLIN1 GPS2 ZDHHC7 FOS HBEGF FKBP5 CAV2 PTK2 H2BC5 PPP5C H2BC1 DLD AXIN1 EP300 H2AC4 CETP TBL1XR1 ARL4C FASN EEPD1 ABCG1 PDHA1 FABP5 FABP6 CYP26B1 GATA3 NR1H2 CITED1 ESR1 H2BC21 RXRA DLAT TBP RARA MYLIP PGR CARM1 KCTD6 H2AZ2;H2AZ1 PIK3R2 ESR2 PIK3R1 FOXA1 SMC3 FKBP4 MYC RAD21 JUND GREB1 STAG1 HDAC3 CXCL12 STAG2 HDAC1 SMC1A PIK3CA TFF1 KANK1 TNRC6C ADH4 MOV10 CXXC5 TFF3-1 TNRC6A-1 AGO4 NRIP1 AGO2 USF2 USF1 AGO3;AGO1 ZNF217 FOSB TNRC6B EBAG9 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CCND1 POLR2E CBFB POLR2F ANGPTL3 POLR2H RUNX1 S1PR3 POLR2L H2BC15;H2BC3;H2BC11;H2BC12 SCD KDM1B RDH5 MAPK1 MAPK3 ABCG8 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events CASR PLA2G4A MCHR2 TAS2R3-1 NMUR2 NMUR1 TAS2R16 BDKRB2 BDKRB1 RGS18 DRD3 RGS17 DRD4 RGS19 RGS13 POMC TAS2R40 RGS16 TAS2R41 RGS21 APP PDE1C GRK2 TAS2R39 ADORA3 ADORA1 PRKACA-1 PPP2R1A PPP1CA TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 PRKCD PRKCA C5AR1 C5 PRKAR2B PRH1-TAS2R14;TAS2R14-3 KPNA2 PDE1B PDE1A TAS2R7 GNAS-1 TAS2R8 ADCY9 PRKAR1B PRKAR1A ADCY4 GRM4 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW ADCY3 ADCY2 TAS2R1 ADCY1 TAS2R4 ADCY8 ADCY7 ADCY6 ADCY5 PRKACB-1 PRKAR2A CAMKK1 CAMKK2 C3AR1 TAS1R2 TAS1R1 TAS1R3 GNAT3 GNAZ GNAI3 OPN1SW C3-1 SAA2;SAA1 CALM3;CALM1 GNAL GNGT1 NBEA RGS9 RGS6 RGS7 PLCB3 PLCB4 PLCB1 PLCB2 SST CCR5 GNA14 GNG10 GABBR2 AGT GNA15 GNG2 GABBR1 GNG5 GNG4 GNA11 GNG8 CXCR4 GNG13 GNAQ GNB2 GNB1 GNAT2 PRKCG GNB4 CHRM2 GNB3 CHRM4 ITPR1 ITPR2 GNB5 ITPR3 RGS11 PPP3R1 HRH4 HTR1E SRC MCHR1 PSAP HTR1F HTR1D HTR1B PPP3CA PPP3CB GNAI1 HTR5A GNAI2 RXFP4 CXCL9 CXCL8 ADRA2C CXCL13 RXFP3 CX3CL1 ADRA2A CCR9 CXCL5;CXCL6 AGTR2 CCR8 FPR1 CCR7 SSTR3 CCR4 GALR3 CCR3 GALR2 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 GALR1 NPBWR1 NPBWR2 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 GPR183 CCL5 PNOC CXCR2 GPR18 CCL1 CCL19 RHO CCR10 CCL16 CCR1 GPR37 CCL25 CCL21 CCL20 PPBP RGR CXCL10 CXCL11 CCL28 CCL27 ACKR3-2 PPP2CB;PPP2CA P2RY12 P2RY13 PF4;PF4V1-1 PPP2R5D P2RY14 PPP2R1B GPR55 MTNR1A MTNR1B RLN3 INSL5 P2RY4 APLN RRH GNAT1 GPR37L1 TAS2R42 ADRA2B PENK PPY PPP1R1B CDK5 PTGDR2 NPY4R2;NPY4R PPP3CC OXGR1 GAL OPRD1 NPB PTGER3 NPW HCAR1 PDYN HCAR2;HCAR3 NPY2R NPY RGS8 CAMK4 NPY1R PCP2 APLNR SUCNR1 OPN3 PDE4D-1 RGSL1 OPN5 PYY GPSM1 GPSM2 GRM3 OPRM1 HEBP1 CAMK2B GRM2 CAMK2D CENPS-CORT;CORT;CENPS CAMK2A LPAR1 GRM7 LPAR2 GRM6 LPAR3 CXCL12 GPER1 FPR2 GRM8 CAMK2G PDE4A GPSM3 GPR17 NPY5R PDE4C OPRK1 SSTR1 LPAR5 SSTR2 NMS SSTR4 NMU SSTR5 RGS14 OPRL1 CNR2 CNR1 RGS20 S1PR3 RGS22 S1PR2 S1PR5 S1PR4 RGS10 ANXA1 RGS12 CX3CR1 KNG1 CCR6 AHCYL1 CCR2 PRKX MAPK1 PMCH RGS4 RGS5 RGS3 RGS1 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription RB1 DDX5 ZCRB1 VHL ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME ABCB1 ADAL NT5C2 ABCG2 SLC22A2 PCK1 ADH1C;ADH1B;ADH1A SLC22A1 SLC22A3 DISEASES OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 97%9675126 Diseases of mitotic cell cycle E2F2 CDK6 CDKN1A CDKN1B ATRX CCND1 CCND3 CCND2 ANAPC15 ANAPC16 DAXX UBE2D1 ANAPC10 CDK4 ANAPC11 CDK2 FZR1 CDC23 CDC26 CDC27 ANAPC7 UBE2C UBE2E1 SKP2 TFDP1 UBE2S TFDP2 CDC16 CCNE2 ANAPC4 CCNE1 ANAPC5 RB1 ANAPC1 ANAPC2 CDKN1C E2F1 E2F3 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 97%201681 TCF dependent signaling in response to WNT USP8 WNT9A SFRP1 SFRP2 WIF1 SOST AKT2 CSNK2A1;CSNK2A3 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 CREBBP CSNK1G2 USP34 PSMD12 KAT5 RYK-1 PSMD11 WNT5A PSMD14 PSMD13 SMARCA4 LEF1 WNT1 H2AC20 PSMA7 FZD1 PSMD8 H2AB2;H2AB3;H2AB1 FZD2 FZD5 PSMB6 FZD4 PSMB7 PSMD6 FZD6 PSMB4 PSMD7 FZD8 PIP5K1B ASH2L PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 XIAP SEM1 PSMA6 PSMC5 PPP2R1A PSMA3 PSMC6 PSMA4 BTRC PSMC3 RSPO3 PSMA1 PSMC4 PSMC1 CTNNB1 H2AJ TCF7 CDC73 TERT LEO1 BCL9L SOX3 TLE4 TLE3 SOX6 TLE2 SOX7 TLE1 SOX4 AXIN2 TCF7L1 PYGO1 WNT3A SOX13 BCL9 PYGO2 HECW1 SOX2 CCDC88C RSPO2 XPO1 RSPO1 H2BC5 RSPO4 AKT1 UBA52 H2BC1 LGR6 LGR5 LGR4 CTNNBIP1 KLHL12 CBY1 YWHAZ DACT1 ZNRF3 AMER1 PPP2CB;PPP2CA WNT8A AXIN1 WNT8B PPP2R5B PPP2R5A EP300 PPP2R5D PPP2R5C RPS27A FRAT2 PPP2R1B MEN1 APC H2AC4 PPP2R5E UBB;UBC SOX17 KMT2B LRP5 LRP6 TPTEP2-CSNK1E;CSNK1E RBX1 GSK3B CAV1 DPY30 SOX9 WNT4 CHD8 CSNK1A1 H2BC21 TNKS WDR5 TNKS2 RNF146 H2AZ2;H2AZ1 WNT3 SMURF2 DKK1 DKK2 DKK4 CUL3 MYC HDAC1 CSNK2A2 TRRAP RBBP5 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RNF43 RUNX3 H2BC15;H2BC3;H2BC11;H2BC12 SRY TCF7L2 KREMEN1 KREMEN2 CTBP1 RUVBL1 DVL1 DVL2 DVL3 H2AC14 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 97%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 CDK1 CCNB2 CCNB1 NEK9 NEK6 PLK1 NEK7 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 97%69656 Cyclin A:Cdk2-associated events at S phase entry AKT2 AKT3 CDK7 CCNA2-1 CCNA1 MNAT1 CKS1B PSMD12 PSMD11 PSMD14 CDC25A PSMD13 CDC25B PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 E2F4-1 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 TFDP1 PSMD3 RBL2 TFDP2 PSMB1 CABLES1 PSMD1 WEE1 ADRM1 MYC PSMC2-1 E2F1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 RBBP4 PSMC4 PSMC1 SKP1 MAX CCND1 LIN54 LIN37 LIN9 LIN52 AKT1 UBA52 CUL1 PTK6 CDK4 CDK2 FZR1 RPS27A E2F5 UBB;UBC CCNE2 CCNE1 RB1 CCNH ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers SOS1 PTPN6 CD19 BLK PLCG2 BLNK BTK DAPP1 CD22 CALM3;CALM1 NCK1 PIK3AP1 LYN ITPR1 ITPR2 STIM1 ITPR3 ORAI2 ORAI1 CD79B CD79A SH3KBP1 PIK3CD AHCYL1 SYK VAV1 PIK3R1 FYN TRPC1 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME DATABASE ID RELEASE 97%4839743 Signaling by CTNNB1 phospho-site mutants PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 CTNNB1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 GSD IB%REACTOME DATABASE ID RELEASE 97%3229133 GSD Ib SLC37A4 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 AVP SLCO4C1 SLCO2B1 SLCO1A2 SLCO2A1 SLC16A2 SLCO1C1 SLCO4A1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs ALOX12 PTGS2-2 ALOX5 ALOX15 HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis PLA2G4A GNA13 MGLL JCHAIN PDPN MPIG6B GP6 STXBP3 STX4 CD84 SDC4 SDC2 ITGB2 SDC3 APP P2RX7 TSPAN7 SDC1 EGF PICK1 PLCG1 RAB5A RAP1B PRKACA-1 HGF PRKG2 DOCK7 ANO6 PPP2R1A MAFK ANO5 PRKCE APOA1 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 GPC1 GPC3 TUBA4A GPC2 GPC5 MYB GPC4 HBG2;HBG1 GPC6 KDM1A JMJD1C DOCK10 DOCK11 KIF5B KIF5A KIF21A PRKAR2B KIF21B KIFAP3 KIF4B;KIF4A AGRN KIF16B KIF20A KIF20B ZFPM2 ZFPM1 GATA6 GATA5 AK3 GATA4 GATA2 KLC1 GATA1 PHF21A KLC4 GUCY1A2 KLC3 GUCY1A1 KLC2 GUCY1B1 PDE1B RACGAP1 PDE1A KIF3B MICAL1 PDE2A IRAG1 KIF3C CYB5R1 CARMIL1 PDE11A NFE2 PDE10A KCNMB1 EHD1 VPREB3 KCNMB2 EHD2 VPREB1 KCNMA1 KIF18A KCNMB3 EHD3 SLC16A8 KCNMB4 SLC16A3 KIF18B FCAMR MAFG NOS1 IGLL5;IGLL1 MAFF PDE9A GYPC RCOR1 ITGA2 CD99L2 DOCK6 GLG1 ITGA10 DOCK5 SELE DOCK4 SELP DOCK3 ESAM DOCK9 SPN DOCK8 KIF12 CD48 KIF11 SELPLG KIF15 CD2 CD244 AKAP10 KIF19 CAPZB KIF13B HMG20B BSG CAV1 KIF1C KIF1B KIF1A JAK2 KIF25 KIF23 KIF22 RBSN HSPG2 KIF6 KIF27 RAD51B KIF9 RAD51C KIF2A KIFC2 KIFC1 PDPK1 IRF1 IRF2 KIF2C KIF2B DOCK2 HBD;HBB AKAP1 CDC42 MFN1 P2RX4 MFN2 SH2B3 A2M SH2B2 SH2B1 CABLES1 CABLES2 SERPINF2 CENPE PLAUR WEE1 KIF26A PLAT SERPINB8 CAPZA1 KIF26B PLAU HRG CAPZA2 SERPINB6-2 S100A10 IFNB1-4 PTPN11 VPS45 TIMP1 SLC8A3 ATP2B4 ATP2A3 ATP2B3 ATP2A2 CD74 ATP2B2 ATP2A1 MMP1 NOS2 ATP2B1 SRI CALM3;CALM1 SLC8A1 SLC8A2 ACTN2 CFL1 ITGAL CD44 SERPINB2 GNGT1 ANXA2 ITGA4 PPIL2 MIF PLG SOD1 ITGA5 KLKB1 SLC7A11 SLC7A10 TTN-1 GNA14 GNG10 GNA15 GNG2 GNG5 NOS3 GNG4 GNA11 GNG8 YES1 SLC7A6 SLC7A7 SLC7A8 SLC7A9 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 GNG13 VEGFA GNAQ GNB2 RAB27B GNB1 GNB4 GNB3 GNB5 ISLR HABP4 CHID1 GTPBP2 SYTL4 TAGLN2 NHLRC2 TEX264 SERPINE1 LY6G6F;LY6G6F-LY6G6D ENDOD1 PECAM1 APOH VTI1B MANF CALU CD36 MAGED2 FERMT3 ECM1 OLA1 CTSW TIMP3 ANXA5 TOR4A SPP2 VEGFB VEGFC VEGFD LHFPL2 PCYOX1L FAM3C LEFTY2;LEFTY1 APLP2 TMX3 RAC1 SELENOP SCG3 RARRES2 CYRIB SCCPDH RHOA LGALS3BP WDR1 PLEK PHACTR2 SRGN ITIH4 ITIH3 CLEC3B CRK CDC37L1 DOCK1 BRPF3-1 P2RX6 P2RX5 P2RX3 STIM1 ITGA2B PTPN1 P2RX2 P2RX1 ORAI2 ORAI1 CDK2 BCAR1 ABCC4 P2RY12 PF4;PF4V1-1 TGFB2 TGFB3 ABL1 MPL THPO ADRA2B CBX5 ITGAV CDK5 MAG ACTN4 SIN3A GP1BA PIK3CG TRPC7 TRPC6 PRKCH TRPC3 HDAC2 THBS1 HDAC1 PTGIR ANGPT4 ANGPT2 ANGPT1 TNFRSF10C;TNFRSF10D;TNFRSF10B;TNFRSF10A DOK2 TEK GRB14-1 SHC1-1 PRKCQ SERPINE2 ITGB3 LRP8 PROS1 RASGRP2 F13A1 RASGRP1 SERPINA5 THBD LYN CD177 FGB FGA GP1BB F2R TREM1 FGG F2 F3 F5 F7 PROCR F8 CXADR F9 SERPING1 SERPINC1 CLU KNG1 SERPIND1 JAML F10 F2RL2 F12 F2RL3 F11 DGKG GP5 DGKE GP9 OLR1 DGKD PROC F13B DGKB RAP1A DGKA MAPK1 MAPK3 ABHD12 CD99 DGKZ SOS1 DGKQ DGKK DGKI DGKH PIK3R3 ABHD6 PIK3R6 PIK3R5 APOB SELL DAGLA DAGLB FCER1G P2RY1 PAFAH2 AAMP AHSG SMPD1 ITGA6 CD47 ATP1B2 ATP1B1 LAMP2 SLC7A5 RAF1 SIRPA;SIRPB1;SIRPG AKT1 STXBP2 PRKCD RAPGEF3 PRKCA RAPGEF4 YWHAZ ADAMTS13 VWF ITGAM MAPK14 PRKCB TF CLEC1B PDGFB GNAS-1 PRKAR1B PRKAR1A PRKCZ ORM2;ORM1 QSOX1 LCP2 CD63 PRKACB-1 ATP1B3-1 KIF3A PRKAR2A TBXA2R GNA12 A1BG F11R FN1 SERPINA3 IGF1 GNAT3 SYK FGR HRAS GNAI3 FYN NRAS FLNA CFD PLCG2 SERPINA1 ARRB1 ITGA1 ITPK1 L1CAM CD9 APBB1IP GAS6 EPCAM CAP1 CD109 PRKCG ITPR1 ITPR2 LCK ITPR3 TLN1 SRC PSAP ARRB2 ALB GNAI1 CSK SPARC GNAI2 PCDH7 ADRA2C JAM2 ADRA2A JAM3 ACTN1 PFN1 HSPA5 GRB7 PTK2 ITGAX PPBP ITGA3 SLC16A1 PPP2CB;PPP2CA PPP2R5B PPP2R5A VAV3 PPP2R5D PPP2R5C PPP2R1B RHOG PPP2R5E VAV1 VAV2 RHOB MMRN1 MERTK APOOL ITGB1 GATA3 INPP5D SLC3A2 VCL IGF2 LAT PPIA TP53 PIK3R2 PIK3CB PIK3R1 ALDOA PIK3CA PTPN6 TGFB1 PDE5A AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467340 AXIN missense mutants destabilize the destruction complex PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 HCN CHANNELS%REACTOME DATABASE ID RELEASE 97%1296061 HCN channels HCN4 HCN3 HCN2 HCN1 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress RPS14 RPS17 RPS16 RPS19 RPS18 AKT2 AKT3 CSNK2A1;CSNK2A3 HSPE1 RPS11 RPL10A RPS10 RPS13 PTGES3-1 RPS12 MAP1LC3B2;MAP1LC3B-1 BMI1 CAPZA3 ETS1 ACTR10 RING1 PGD ZBTB17 RNF2 HDAC6 DCTN6 DCTN5 DCTN4 CBX8 CBX6 PHC2 PHC1 CBX4 RPS25 CBX2 RPS27 TXNIP RPS29 PHC3 RPS20 SKP2 RPS21 RPS24 EGF NFYA-1 RPS23 RPL36AL-1 YWHAE HSPB8 HIKESHI GFPT1 CCAR2 DNAJC2 DNAJC7 ST13;LOC107986532 CRYAB RPS19BP1 HSPA4L HSPA14 ACTR1A HSPA13 DNAJB1 PDGFA HSPH1 BAG5 MAFK AREG DNAJB6 BAG3 NFE2L2 BTRC BAG1 HSPA1L HSPA4 APOA1 SKP1 HSPA6 HSPA12A EEF1A1 HSP90AA1 HSPA12B RPS27L RPS15A RPS3 AQP8 AJUBA UBA52 RPS2 DYNC1I2 DCTN2 DCTN3 CUL1 RPL18A FAU ATF3 VCP-1 RPS27A RPS6KA3 RPS6KA2 UBB;UBC RPS6KA1 RPS9 RPS7 MAP2K3 RPS8 DYNC1H1 MAP2K4 RPS5 MEF2C RPS6 MAPKAPK3 MAPK9 RPSA MAPK8 MAP2K7 HSP90B1 MAPK10 TXN HELZ2 STAT3 MAFG BCL2 DDIT3 ACD TINF2 TERF2 BCL2L1 POT1 CREB3 DCSTAMP TERF2IP CREB3L3 TERF1-1 CREB3L4 CREB3L1 CREB3L2 CREBRF NLRP3 CAPZB SQSTM1 GSK3A HSP90AB1 RPS4X RPS3A HBD;HBB IL1A NFYB NFYC CAPZA1 CAPZA2 VHL IFNB1-4 RPL15-1 HIRA EIF2S2 FOXO3 EIF2S3;EIF2S3B EIF2S1 ATP6V1H LMNB1 IDH1 ATF5 GSTA3;GSTA1 NPRL2 NPRL3 EIF2AK1 EIF2AK4 H1-0 H1-3 H1-2 H1-5 SOD2 H1-4 SOD1 NOX5 EXTL1 EGLN1 EGLN3 EGLN2 CASTOR1 WTIP CASTOR2 ERO1A FBXL17 BACH1 SESN1 MAP3K5 MUL1 ARFGAP1 IMPACT CCNE2 HM13 CCNE1 RB1 SH3BP4 SRPRB-1 SLC7A11 NUDT2 EHMT2 EHMT1 PREB KDELR3 H2AC14 OMA1 DELE1 FKBP14 HERPUD1 MYDGF MINK1 DEPDC5 MED1 YIF1A HDGF ETS2 ERN1 HTRA2 GCN1 HMGA2 CABIN1 GOSR2 SOD3 CCS BMT2 TSPYL2 DDX11 ASF1A SEH1L H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 VEGFA ABCF2-H2BE1;ABCF2 PPARGC1A PRDX3 SSR1 CREBBP ATF2 WDR59 PRDX6 HIF3A MIOS KAT5 WDR24 UBN1 CDKN2D CDKN2C EPO H2AC20 ERF RRAGA TNIK RRAGC RRAGB H2AB2;H2AB3;H2AB1 IGFBP7 EZH2 WFS1 RRAGD RPL10;RPL10L-1 TPP1 SRXN1 HIF1AN GPX6 CAT PRKCI GPX5 GPX8 PRDX2 GPX7 WIPI1 TFDP1 CTDSP2 PRDX1 TFDP2 CEBPG DNAJB9 FNIP1 FNIP2 NCOA1 TXNRD2 NCOA2 DNAJA4 E2F1 LONP1 NCOA6 E2F3 C12orf66 LIMD1 UBXN7 JUN ATM ITFG2 KPTN MAP4K4 ATR TATDN2 MAPK7 SZT2 CDKN1A UBE2D3-1 SIRT1 PDIA6 CDKN1B PDIA5 HSBP1 DPP3 RPLP0 NCOR2 HSF1 KLHDC3 DNAJA1-1 BRCA1 H2AJ SRPRA FLCN RPTOR ATF6B NCOR1 RPLP2 RPL36-1 FOS CDKN2B SUZ12 H2BC5 EPAS1 SIRT3 H2BC1 ATF4 STAP2 RPA1 PTK6 RPA2 NPLOC4 CDK4 CDK2 ID1 UFD1 CYCS-1 EXTL2 IGFBP1 RPA3 EP300 LAMTOR2 LAMTOR1 LAMTOR4 H2AC4 ADD1 LAMTOR3 LAMTOR5 EXTL3 MRE11 TBL1XR1 SESN2 NBN FABP1 CDK6 MAPKAPK5 MDM2-2 RPL22L1 SLC38A9 MAP2K6 RPL37A-1 GSK3B RHEB PPP1R15A HSPA2 CITED2 MDM4 SIN3A H2BC21 EED MLST8 H2AZ2;H2AZ1 COX4I1 COX4I2 ME1 ARNT FKBP4 CAMK2B CAMK2D CAMK2A RPL13A-1 SMARCD3 HDAC3 HSPD1 CXXC1 CAMK2G MTOR RAD50 RBBP4 NRIP1 LY96 CRTC1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 TLR4 SHC1-1 H2BC15;H2BC3;H2BC11;H2BC12 UBE2D3;UBE2D2 NDUFA4 RPL23A ATP7A DEFA6;DEFA4;DEFA5 MAPK1 MAPK3 GRB10 P4HB APOB EP400 CCNA2-1 CCNA1 ATOX1 KDM6B RPL27A PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 CLOCK PSMA7 DNAJC3-1 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PALB2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 ATP6V1E1 PSMC3 ATP6V1E2 PSMA1 ATP6V1G1 PSMC4 ATP6V1G2 PSMC1 G6PD ATP6V0D1 ATP6V0D2 HSPA1A;HSPA1B ATP6V1A XPO1 KHSRP AKT1 NUP214 DIS3 PRKCD ATP6V1D MAPKAPK2 ATP6V1C1 ATP6V1F PARN GSTP1 EXOSC7 GCLC ATP6V1C2 EXOSC6 GCLM EXOSC5 CHD9 EXOSC4 RPL12-1 EXOSC9 SYVN1 EXOSC8 DCP2-1 EDEM1-1 EXOSC3 EXOSC2 EXOSC1 HSPA8 MAPK14 MAPK11 TCIRG1 CRTC2 CRTC3 ATP6V0B RAI1 BLVRB CLEC1B DYNC1LI1 MEF2D DYNC1LI2 ATP6V1B2 ATP6V0C BLVRA RBX1 ATP6V1B1 NRF1 NPAS2 MBTPS1 RPL26L1 MBTPS2 RPL4 RPL30 ATP6V1G3 RPL3 AKT1S1 RPL32 RPL31 RPL34 RPL8 SP1 RPL9 RPL6 ATP6V0E2;ATP6V0E1 RPL7 RPL35 RPL38 RPL39 HYOU1 RPL21 RPL23 RPL22 CUL3 RPL24 RPL27 RPL26 E2F2 RPL29 RPL28 NUP107 PRKAA2 NUP188 NUP210 RPL3L NUP93 NUP205 RPLP1-2 AAAS DNAJB11 NUP160 NUP85 TPR NUP88 NCF1 NCF2 NUP155 NCF4 TALDO1 NUP153 TRIB3 ELOC-1 RPL11 NUP62 RPL14 ELOB RPL13 STIP1 RPL18 RPL17 RPL19 NDC1 SEC13 NUP133 NUP50 POM121;POM121C NUP54 COX7B NUP42 DNAJA2 COX7C NUP43 COX8A RAE1 COX8C RANBP2 TLN1 ASNS COX5B LMNA NUP35 ALB COX5A NUP37 RPL7A GPX1 COX6C CXCL8 COX6A1 HSPA5 COX6A2 CCL13;CCL2 EIF2AK3 TXNRD1 TXN2 RPL35A ATF6 FKBP5 SLC46A1 COX6B2 KEAP1 COX6B1 NOX4 CHAC1 AMER1 TRIM21 CALR-1 PPP2R5B HIGD1A STOML2 PHB2 YME1L1 PGRMC2 CA9 SEC31A DYNC1I1 TGS1 RORA NR3C1 CHD6 ESR1 NR3C2 AR RXRA PGR CARM1 DCTN1 PPARA TP53 HBA2;HBA1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 CYBB CYBA HIF1A CUL7 MYC COX7A2L-1 JMJD7-PLA2G4B;PLA2G4B CUL2 ARNTL TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 NQO1 HMOX1 AGO3;AGO1 HMOX2 TNRC6B NR1D1 CSNK2B RPL5-1 BAG4 BAG2 ABCG2 COX7A2 HSPA9 CEBPB ANAPC15 ANAPC16 UBE2D1 RELA ANAPC10 ANAPC11 FZR1 CDC23 CDC26 ACADVL CDC27 TKT ANAPC7 CDKN2A UBE2C UBE2E1 NFKB1 IL6 UBE2S CDC16 ANAPC4 ANAPC5 ANAPC1 ANAPC2 ABCC3 ABCC1 RPS15 KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants FLT3 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.7 Platelet Adhesion to exposed collagen GP1BA FCER1G ITGA1 ITGB1 ADAMTS13 VWF ITGA2 ITGA10 GP6 GP5 GP9 FYN LYN GP1BB DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection DPM1 DPM2 DPM3 SNRPD2 DNAJC10 SNRPD1 ELAVL2 P4HB SNRPD3 VIM MAP1LC3B2;MAP1LC3B-1 ATG14 SDC4 H2BC18 RPN2 SDC2 SDC3 RPN1 PIK3R4 SNRPE-2 DNAJC3-1 SDC1 MAGT1 IKBKE PTBP1 HNRNPH1 HNRNPA1-1 PRKG2 HNRNPM NEK2 CTNNB1 APOA1 HSP90AA1 CDC73 CANX LEO1 GPC1 HSPA1A;HSPA1B P4HA1 GPC3 RBMX P4HA2 ELAVL1 GPC2 XPO1 GPC5 P4HA3 UBA52 GPC4 GPC6 STAT2 XRN1 TJP1 STING1 AGRN VCP-1 RPS27A TUSC3 UBB;UBC KPNA2 HSPA8 PABPC1;PABPC3 EIF4G1 RPSA TMEM258 SNRPF SNRPB DDX5 OST4 MAVS HNRNPC OSTC STT3A STT3B HSPG2 HSP90AB1 KPNA4-1 DDOST HYOU1 DAD1 CPSF2-1 MBL2-1 ACOT2;ACOT1 ATL2 PIK3C3 NUDT21 BECN1 LY6E EIF4A2 FUS NACA SNRPG-2 EIF4A1 BCAS2 C1S HNRNPA0 HNRNPA3 NFKBIB GPKOW CDC5L KPNA1 EIF4E DHX9 GTF2F1 GTF2F2 SUGP1 TAOK1 PABPN1-1 MMP9 PEX19 TSG101 DNAJB11 PPIE CLINT1 FURIN SUN2 HNRNPF HNRNPA2B1 POLR2J;POLR2J2;POLR2J3 HNRNPU HNRNPR NMT1 SNRPA1 WDR61 BTF3 HNRNPL HNRNPK HNRNPD RPL18 WDR33 H2AC14 GAS6 ISY1;ISY1-RAB43 PDCD6IP NCBP1 PHF5A AUP1 IPO7 PAPOLA TXNL4A SNRPN NCL-1 PLRG1 DNAJC8 CD33-1 POLR2A FIP1L1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A POLR2B SEC11C POLR2C SNRNP40 DNAJA2 POLR2D PPIL3 PPIL4 PPIL6 SRRM2 POLR2G COG1 POLR2I CRNKL1 DAXX CSTF3 CSTF2 H2AC20 NCBP2-1 HNRNPH2 MAPKAP1 EMC4 SPCS3 SPCS2 SPCS1 CWC25 PPIL1-1 CWC27 CWC22 PRPF6 PRPF8 CPSF4 CPSF1 SNW1 CPSF3 CWC15 CGAS UBA7 RBM5 RPTOR HSPA5 TAL1 C4BPA C4BPB CLDN1 IFIH1 LOC110384692;C4A;C4B_2;C4B TRIM25 EXOC1 SF3B1 GRPEL1 H2BC5 GBF1 AP2A1 H2BC1 AP2B1 AP2A2 RICTOR PQBP1 AP2S1 NPLOC4 SRRT UFD1 CALR-1 KPNA7 KPNA5 KPNA3 NRBP1 SNRNP200 H2AC4 ATG7 FASN CTNNBL1 PRCC MERTK KDELR1 CCAR1 U2AF1L5;U2AF1 EIF4A3 TIMD4 CD2BP2 CTR9 RTF1 PCBP1 PCBP2 SYMPK CDC40 RBM10 SCAP PAF1 SRRM1 RETREG1 DHX15 DHX16 KPNB1 SRSF2 SRSF3 UBE2I SRSF5 SRSF6 SRSF7 SRSF9 WBP11 HNRNPUL1 H2BC21 SRSF1 RTN3 U2AF2 PRR5 DDX46 DHX38 DDX42 SRSF11 SUMO1 RBM17 DYNLT1 SRSF4-1 BUD31 ALYREF RBM22 MLST8 RNPS1 DDX23 CSTF2T RRBP1 SMNDC1 U2SURP CLP1 PIK3R1 YBX1 TYRO3 CAMK2B UBA6 CAMK2D UBA5 CAMK2A UBR4 MRC1 CAMK2G MTOR SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 LY96 DDX3X-1 SF3A3 SF3A1 SF3A2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 XAB2 POLR2E RIPK1 CPSF7 CLEC5A POLR2F CD14 POLR2H VTN TLR4 BAG2 POLR2L CHERP PROS1 UBA3 EIF4G3 EIF4G2 H2BC15;H2BC3;H2BC11;H2BC12 EIF4E3 LYN UBA1 NFKBIA F2 CLEC4M;CD209-2 PUF60 SNRPB2 AQR CLU PRPF19 PCF11 H2AC16;H2AC11 MAPRE3 AXL HDLBP EFTUD2 PDIA3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 97%187706 Signalling to p38 via RIT and RIN NGF BRAF NTRK1 RIT1 RIT2 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress ABL1 ITGB1 RAMP2 GNG10 GNAS-1 GNG2 ADCY9 GNG5 NOS3 GNG4 PRKAR1B GNA11 ITGAV PRKAR1A GNG8 ADCY4 ADCY3 CAPNS1 ADCY2 ADCY1 CAPNS2 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 CAPN2 PRKACB-1 GNAQ GNB2 PRKAR2A GNB1 ADM GNB4 VCL GNB3 P2RY2 PRR5 GNB5 TLN1 CDH5 PDPK1 PANX1 CALCRL MLST8 PIK3CD MAPKAP1 PIK3R2 PIK3CB PECAM1 IKBKE FYN PRKACA-1 PPP2R1A PIK3CA MTOR TRPV4 KDR CTNNB1 CHUK CALM3;CALM1 IKBKB ITGB3 IKBKG MMP14 PKN2 PTK2 AKT1 PPP2R2A;PPP2R2D NFKBIA GNGT1 ANXA2 RICTOR STAT1 PTPN1 RELA PPP2CB;PPP2CA ITGA5 PRKAR2B YAP1-1 PPP2R1B NFKB1 FLT4 PIEZO1 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology HDAC1 CAMK4 WDR5 NCOR2 RBBP5 NCOR1 ASH2L CALM3;CALM1 TBL1XR1 DPY30 GPS2 KMT2D SIN3A HDAC3 PRKACA-1 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX F8 F9 F10 SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.7 Selenoamino acid metabolism RPS14 RPS17 GNMT RPS16 AIMP1 MARS1 RPS19 RPS18 AIMP2 EPRS1 RPS11 RPL10A RPS10 RPS13 RPS12 RARS1 SECISBP2 RPL27A LARS1 SCLY EEF1E1 AHCY RPL10;RPL10L-1 RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 RPL36AL-1 RPL7A INMT SARS1 RPLP0 RPLP2 TXNRD1 RPL36-1 RPL35A MAT1A RPS27L RPS15A RPS3 UBA52 RPS2 CTH NNMT KARS1 CBS;CBSL RPL18A FAU RPL12-1 RPS27A SEPHS2 RPS9 RPS7 RPS8 RPS5 EEFSEC DARS1 RPS6 RPSA RPL22L1 HNMT RPL37A-1 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL8 QARS1 RPL9 RPL6 RPL7 RPS4X RPL35 RPL38 RPS3A RPL39 RPL21 RPL23 RPL22 RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPL3L RPL5-1 RPLP1-2 IARS1 SEPSECS RPL23A PAPSS2 PAPSS1 RPL11 RPL14 RPL13 RPL18 RPL17 PSTK RPL19 RPS15 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 97%1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME%R-HSA-9026519.2 Activated NTRK2 signals through RAS BDNF SOS1 HRAS NRAS NTRK2 DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 97%9734767 Developmental Cell Lineages LAMA5 LAMA3 AREG CSF1 TGFA LAMA2 IFNG LAMA4 FN1 LAMB3 LAMB2 LAMB1 FGF2 FGF7 VTN LAMA1 EGF FGF10 PRL LAMC3 LAMC2 LAMC1 FGF4 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME DATABASE ID RELEASE 97%9855142 Cellular responses to mechanical stimuli GJA1 ABL1 ITGB1 RAMP2 GNG10 GNAS-1 GNG2 ADCY9 GNG5 NOS3 GNG4 PRKAR1B GNA11 ITGAV PRKAR1A CACNA1H GNG8 ADCY4 ADCY3 CAPNS1 ADCY2 ADCY1 CAPNS2 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 CAPN2 CACNB2 PRKACB-1 CACNB3 GNAQ GNB2 PRKAR2A GNB1 ADM GNB4 HSPG2 VCL GNB3 P2RY2 PRR5 GNB5 TLN1 CDH5 PDPK1 PANX1 CALCRL MLST8 P2RX7 PIK3CD MAPKAP1 PIK3R2 PIK3CB PECAM1 IKBKE CACNG7 FYN PRKACA-1 PPP2R1A PIK3CA MTOR TRPV4 KDR CTNNB1 CHUK CALM3;CALM1 IKBKB ITGB3 IKBKG MMP14 PKN2 PTK2 AKT1 PPP2R2A;PPP2R2D NFKBIA GNGT1 ANXA2 RICTOR STAT1 PTPN1 RELA PPP2CB;PPP2CA ITGA5 PRKAR2B SPP1 YAP1-1 PPP2R1B NFKB1 FLT4 CACNB1 PIEZO1 CACNA2D1 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching PRIM2 PRIM1 POLA1 POLA2 POLD3 POLD4 POLD2 RFC5 RFC3 RFC4 RFC2 RFC1 POLD1 PCNA REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5357905 Regulation of TNFR1 signaling SPATA2 TNFAIP3 SHARPIN TBK1 USP21 USP4 ULK1 RACK1 MIB2 UBE2D3-1 TNFRSF1A TRADD CYLD RBCK1 OTUD1 TRAF2 BIRC2 CHUK BIRC3 CASP8 OPTN-1 RIPK1 FADD TNF IKBKB IKBKG UBE2D3;UBE2D2 UBA52 TRAF1 UBE2D1 MAPKAPK2 TAX1BP1 RPS27A UBB;UBC IKBKE SPPL2B SPPL2A CLIP3 STUB1 OTULIN RNF31 XIAP USP2 OTUD7B FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex NCBP1 CDK7 POLR2E POLR2F CTDP1 POLR2H GTF2F1 MNAT1 GTF2F2 POLR2L POLR2A POLR2B POLR2C POLR2D ERCC3 POLR2G ERCC2 POLR2I GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 SUPT5H POLR2J;POLR2J2;POLR2J3 NCBP2-1 NELFB GTF2H2C;GTF2H2C_2;GTF2H2 CCNH NELFCD NELFA NELFE SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 97%399954 Sema3A PAK dependent Axon repulsion HSP90AB1 SEMA3A PLXNA2 LIMK1 PLXNA3 PAK1 RAC1 HSP90AA1 FES PAK3 NRP1 FYN CFL1 PLXNA4 PAK2 PLXNA1 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9940465 ChAHP complex assembly H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AJ CBX3-1 ADNP2 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 ADNP H2AC4 CBX1 CHD4 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 H2BC1 H2AC14 H2BC21 SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.10 Signaling by ERBB2 USP8 PTPN18 GAB1 SOS1 MATK PIK3CA PRKCE AKT2 AKT3 HSP90AA1 YES1 NRG1 NRG2 GRB7 RHOA EREG BTC SHC1-1 NRG3 NRG4 MEMO1 DIAPH1 HBEGF AKT1 UBA52 PRKCD PRKCA PTPN12 PTK6 SRC RPS27A UBB;UBC EGF CDC37 ERBB2 ERBIN PLCG1 EGFR HRAS PIK3R1 RNF41 FYN STUB1 CUL5 NRAS COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6C MOV10 TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 97%6803544 Ion influx efflux at host-pathogen interface ATOX1 SLC11A1 PDZD11 ATP7A THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) RDH10 MYO7A RDH12 RDH11 HSD17B6 RBP3 RPE65 TTR LRAT RDH5 RDH8 STRA6 HSD17B1 CYP4V2 RHO RBP4 RLBP1 ABCA4 SDR9C7 DHRS9 RBP1 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 97%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2R1B PPP2R1A TFDP1 PRIM2 TFDP2 PRIM1 RB1 POLA1 POLA2 PPP2CB;PPP2CA PPP2R3B E2F1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes CDK1 SMC4 SMC2 NCAPG NCAPH NCAPD2 CCNB2 CSNK2A2 CCNB1 CSNK2A1;CSNK2A3 CSNK2B DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%2172127 DAP12 interactions SIGLEC5;SIGLEC14 SOS1 PIK3CA TREM2 GRAP2 PLCG2 KLRC4-KLRK1;KLRK1 RAC1 SIGLEC15 KLRC4;KLRC3;KLRC2;KLRC1 BTK B2M TYROBP KLRD1 LCP2 CLEC5A HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E SIRPB1 TREM1 LCK VAV3 CD300E SYK PIK3R2 PIK3CB PLCG1 HRAS VAV2 PIK3R1 FYN NRAS RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.4 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening GTF2B CDK7 POLR2E GTF2A1 GTF2A2 POLR2F POLR2H GTF2F1 MNAT1 GTF2F2 TAF9 POLR2L POLR2A POLR2B POLR2C GTF2E1 POLR2D ERCC3 GTF2E2 POLR2G TAF9B ERCC2 POLR2I GTF2H1 GTF2H3 GTF2H4 TAF15 TAF12 TBP TAF13 TAF10 TAF11 POLR2J;POLR2J2;POLR2J3 TAF8 TAF7 TAF4B TAF6 TAF5 TAF4 TAF7L TAF3 TAF2 TAF1 GTF2H2C;GTF2H2C_2;GTF2H2 CCNH REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 97%9854907 Regulation of MITF-M dependent genes involved in metabolism SIRT1 PPARGC1A SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 97%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) RWDD3 SUMO1 SUMO3 UBE2I SUMO2 UBA2 SAE1 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%9652282 Drug-mediated inhibition of ERBB2 signaling CDC37 ERBB2 ERBIN HSP90AA1 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway FGF20 SOS1 SPTBN2 FGF23 MARK3 IL2RB PPP1CC RGL1 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 DLG1 EGF PSMD3 IL5 ERBB2 PSMB1 PSMD1 EGFR JAK1 PDGFRA ADRM1 FGF6 PSMC2-1 PSMA2-1 PPP1CB PSMA5 RAP1B HGF SEM1 PSMA6 PRKG2 PSMC5 PPP2R1A TYK2 PSMA3 MET PSMC6 PSMA4 PTPN3 AREG PSMC3 PSMA1 PSMC4 PSMC1 IL5RA FGF7 FGF22 FGF3 FGF10 RAF1 ICMT YWHAB KIT UBA52 ZDHHC9 VWF RPS27A UBB;UBC GOLGA7-1 CDK1 FLT3LG PDGFB RBX1 BCL2L1 KLB GRIN2B PDGFRB FGF19 FGFR4 JAK2 FLT3 LYPLA1-1 FN1 DUSP8 DUSP9 SPRED3 SPRED2 RASA4;RASA4B SPRED1 SYNGAP1 HRAS FNTA RASA3 RASA1 FYN RASA2 CUL3 RASAL1 NRTN RASAL2 RASAL3 NCAM1 NRAS DAB2IP PSPN NF1 GFRA2 KBTBD7 GFRA4 ARTN PTPN11 DUSP5 DUSP2 DUSP1 PAQR3 IL3RA PTPN7 CALM3;CALM1 ACTN2 CNKSR2 CNKSR1 PEBP1 GRIN2D IL6R EPGN ARRB1 DLG2 DLG3 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 RASGRF1 ABHD17C ABHD17B ABHD17A RCE1 SHC3 PTPRA NEFL SPTB LRRC7 IL2RA MAPK12 APBB1IP ARL2 TGFA SPTBN4 CSF2RB SPTBN5 CSF2RA MAP3K11 DUSP4 RASGRF2 GRIN1 DUSP6 DUSP7 GFRA3 IRS2 SHC2 RALGDS TLN1 SPTA1 IL2 IL3 SRC IQGAP1 ARRB2 CSK FNTB;CHURC1-FNTB NRG1 NRG2 ARAF EREG BTC RASGRP3 NRG3 NRG4 SPTBN1 WDR83 RGL3 PDE6D RGL2 HBEGF PEA15 PTK2 IL17RD RAPGEF2 PPP5C RASGEF1A CSF2 ITGA2B PPP2CB;PPP2CA SPTAN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B LAMTOR2 PPP2R5E LAMTOR3 PHB KSR1 KSR2 RET FGF2 VCL GFRA1 GDNF IRS1 PIK3R2 PIK3CB PIK3R1 IL2RG CAMK2B BRAP CAMK2D CAMK2A JAK3 FRS2 PIK3CA CAMK2G MRAS RANBP9 ANGPT1 KRAS TEK SHC1-1 PRKCQ ITGB3 RASGRP1 RASGRP4 DUSP16 DUSP10 FGB FGA DLG4 FGG MAP2K2;MAP2K1 IL6 RAP1A MAPK1 BRAF MAPK3 SHOC2 FGF1 FRS3 FGF4 FGF16 FGF9 FGF18 KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway AKT2 AKT3 CSNK2A1;CSNK2A3 MAP1LC3B2;MAP1LC3B-1 SOD3 ABCF2-H2BE1;ABCF2 PGD CREBBP PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 SRXN1 PSMB4 PSMD7 PRKCI PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PALB2 EGF PSMD3 PRDX1 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 UBXN7 PSMA6 PSMC5 PSMA3 PDGFA PSMC6 MAFK PSMA4 AREG BTRC NFE2L2 CDKN1A PSMC3 PSMA1 DPP3 PSMC4 PSMC1 SKP1 BRCA1 CCL13;CCL2 EIF2AK3 TXNRD1 G6PD AKT1 UBA52 KEAP1 PRKCD ATF4 CUL1 NPLOC4 AMER1 TRIM21 GCLC UFD1 GCLM EP300 VCP-1 RPS27A UBB;UBC SESN2 TXN RBX1 MAFG BCL2 BCL2L1 GSK3B SQSTM1 CHD6 SP1 ME1 CUL3 MYC CSNK2A2 PRKAA2 NQO1 HMOX1 CSNK2B ABCG2 IDH1 GSTA3;GSTA1 RELA TALDO1 TKT CDKN2A FBXL17 BACH1 SESN1 NFKB1 MUL1 SLC7A11 ABCC3 ABCC1 PROCESSING OF ANTIGEN IN GERMINAL CENTER B CELLS%REACTOME%R-HSA-9979719.1 Processing of antigen in germinal center B cells DYNC1LI1 SPTBN2 DYNC1LI2 KIF18A CTSO ACTR1B CTSH CTSF CTSE CTSC HLA-DMA HLA-DMB KIF11 DYNC1I1 KIF15 CAPZA3 CTSA ACTR10 CAPZB HLA-DOA HLA-DOB KIF3A KIF23 KIF22 DCTN6 DCTN5 HLA-DPB1-1 DCTN4 KIF2A HLA-DQB2;HLA-DQB1 OSBPL1A HLA-DPA1 RILP KIF2C HLA-DRB5;HLA-DRB1;HLA-DRB3;HLA-DRB4 KIF2B DCTN1 HLA-DRA CENPE KIF26A CAPZA1 CTSS CAPZA2 ACTR1A CTSK CTSD CTSB CTSV;CTSL RAB7A DYNC1I2 DCTN2 DCTN3 KIF5B KIF5A KIFAP3 KIF4B;KIF4A KIF20A KLC1 DYNC1H1 KLC4 KLC3 KLC2 RACGAP1 IFI30 KIF3B KIF3C REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells INSM1 NEUROG3 NEUROD1 NKX2-2 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex CRY1 TPTEP2-CSNK1E;CSNK1E ARNTL CSNK1D CLOCK PER2 CREBBP PER1 KMT2A NPAS2 CRY2 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%427413 NoRC negatively regulates rRNA expression SAP130 SUDS3 SAP30BP CDK7 MNAT1 BAZ2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SIN3B SIN3A H2BC21 SMARCA5 UBTF DNMT3B H2AC20 TBP H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G POLR1H GTF2H2C;GTF2H2C_2;GTF2H2 HDAC2 HDAC1 TAF1D TAF1B TAF1C SAP30L H2AJ TAF1A H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POLR2E SAP18 POLR2F POLR2H POLR2L H2BC15;H2BC3;H2BC11;H2BC12 H2BC5 ERCC3 MBD2 H2BC1 ERCC2 GTF2H1 GTF2H3 GTF2H4 ARID4B TTF1 H2AC4 SAP30 CCNH DNMT1 H2AC14 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle UACA DBN1 STOM NSFL1C PAK1 WDR11 SLC4A7 TMEM59 VANGL1 PAK5 PAK4 RAB7A JUP CAV1 PAK2 OSBPL11 NIPSNAP2 MTR-1 LCK BUB1B-PAK6;PAK6 ROCK2 ARHGDIG RALGAPA1 VCP-1 FAM91A1 TFRC RHOH LAMTOR1 ARHGDIA VAMP3 ARHGDIB DBT CSK ZAP70 ROCK1 SLC1A5 GASTRULATION%REACTOME DATABASE ID RELEASE 97%9758941 Gastrulation CXCR4 IHH CREBBP PAX6 MESP2 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 SMAD2;SMAD3 LEF1 FOXA2 RBPJ DLL1 PSMA7 DLL3 PSMD8 LFNG PSMB6 PSMB7 MAML2 PSMD6 MAML1 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 NOTO PSMB1 PSMD1 SOX1 HES7 MAML3 EPHA4 ZIC2 OTX2 ADRM1 POU3F1 MSGN1 TBX6 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 SNW1 PSMA3 PSMC6 MAMLD1 PSMA4 RIPPLY2 PSMC3 FGFR1 PSMA1 PSMC4 TEAD2 PSMC1 KAT2B CTNNB1 TCF7 TEAD4 KAT2A TCF7L1 WNT3A DLX5 POU5F1;POU5F1B PAX3 SOX2 PAX7 ZIC1 MYB MSX1 FOXF1 FGF8 EP300 FOXH1 GATA6 GATA4 ZEB2 EOMES TBXT NANOG;NANOGP8 SOX17 GSC TBPL2 MIXL1 SNAI1 FOXC2 FOXC1 ZNF521 FGF2 NOG CDH1 OSR1 PAX2 BMP4 PAX8 LHX1 SHH SMAD4 FOXA1 TFAP2A TFAP2C TFAP2E;TFAP2B YAP1-1 TCF7L2 FGF4 TRIM33 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 97%4793954 Defective MOGS causes CDG-2b MOGS MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 97%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport SLC34A2 SLC34A1 PDZD11 SLC4A7 SLC26A11 SLC12A2 SLC12A4 SLC12A5 SLC12A7 SLC26A2 SLC6A4 SLC26A1 SLC35B4 LCN15 LCN12 APOD SLC35A2 SLC35A3 SLC33A1 SLC35C1 ARL2BP LCN1 SLC27A6 SLC29A4 SLC28A2 SLC25A5 SLC29A1 SLC28A1 SLC29A3 SLC27A4 SLC29A2 SLC17A8 SLC28A3 SLC25A6 SLC2A8 SLC30A3 SLC30A2 SLC39A10 SLC30A1 SLC39A14 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A1 SLC39A3 SLC5A6 SLC7A5 SLC5A7 SLC10A6 SLC9A2 SLC9A3 SLC9A4 SLC35B3 SLC9A5 SLC9A6 SLC35B2 SLC9A7 SLC9A8 SLC9A9 SLC22A3 SLC22A8 SLC27A1 SLC25A1 SLC22A6 SLC5A12 SLCO2B1 SLC16A2 SLC13A5 SLC13A2 SLC22A4 SLC13A3 SLCO1C1 SLC22A5 SLCO4A1 SLC35D1 SLC35D2 SLC16A8 SLC16A3 SLC26A7 SLC26A9 SLC26A6 SLC14A1 SLC14A2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 SLC47A1 BSG SLC25A26 SLC22A15 SLC5A9 SLC22A16 SLC30A10 SLC5A4 SLC2A11 SLC2A12 SLC13A1 SLC13A4 SLC5A10 SLC30A8 SLC45A3 SLC30A5 MFSD4B-2 SLC20A1 SLC31A1 SLC35A1 SLC41A2 SLC41A1 SLC2A6 SLC2A7 SLC50A1 SLCO4C1 SLC8A3 SRI SLC36A4 CALM3;CALM1 SLC6A7 SLC8A1 SLC8A2 SLC2A13 SLC5A11 SLC5A3 SLC32A1 SLC6A13 SLC6A1 SLC4A1 SLC4A4 SLC43A2 SLC1A1 SLC43A1 SLC1A2 SLC1A3 SLC3A1 SLC1A4 SLC7A11 SLC1A5 SLC6A20 SLC7A10 SLC1A6 SLC7A1 SLC1A7 SLC7A3 SLC25A29 SLC38A3 ARL2 SLC38A2 SLC38A5 SLC38A4 SLC36A1 SLC6A19 SLC39A4 SLC38A1 SLC36A2 SLC6A15 SLCO2A1 SLC6A14 SLC16A10 SLC6A6 SLC7A6 SLC7A7 SLC26A4 SLC7A8 SLC26A3 SLC7A9 SLC5A8 SLC22A12 SLC22A18 SLC5A5 SLC24A5 SLC40A1 SLC22A2 HEPH SLC22A1 SLC6A9 SLC17A6 SLC17A7 SLC5A2 SLC16A7 EMB CP SLC16A1 SLC6A12 SLC6A11 SLC12A3 SLC12A1 SLC12A6 SLC3A2 SLC24A2 SLC5A1-1 SLC9A1 SLC24A3 SLC8B1 SLC4A8 AHCYL2 SLC4A9 SLC4A10 SLC4A2 SLC4A3 SLC4A5 SLCO1A2 SLC2A9 SLC25A18 SLC6A5 SLC6A2 SLC25A10 SLC6A3 SLC25A4 SLC2A10 SLC25A11 RUNX1 FGF21 CTNS SLC24A1 SLC24A4 SLC25A22 SLC2A4 SLC11A2 SLC44A5 SLC2A1 SLC2A2 SLC44A3 SLC44A4 SLC44A1 SLC44A2 SLC17A5 AVP SLC15A1 SLC11A1 SLC20A2 SLC15A3 SLC15A4 RSC1A1 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%2682334 EPH-Ephrin signaling EPHA5 ARHGEF7 EPHA7 EPHA6 EPHA8 MYL6 ARPC4 ARPC5 NGEF EPHA1 LIMK2 ARPC2 EPHA3 LIMK1 ARPC3 PAK1 EPHA10 YES1 MYL12A PSENEN ACTB-1 PAK3 GRIN2B GRIN1 NCK2 MYH9 SDC2 ACTR2 SDCBP ARPC1B ARPC1A ADAM10 EFNA5 WASL EFNA4 EFNB2 EFNB1 EFNB3 ROCK2 EFNA1 PSEN1 EFNA3 EFNA2 ACTG1 CDC42 NCSTN CLTB HRAS EPHA4 RASA1 FYN ROCK1 CLTCL1 ARHGEF28 MYH14 RAC1 MYH11 MYH10 RHOA MMP2 KALRN MMP9 MYL12B CFL1 EPHA2 CLTC LYN PTK2 CLTA AP2A1 PAK2 AP2B1 TIAM1 AP2A2 DNM1 ACTR3-1 AP2S1 GIT1 VAV3 PSEN2 ITSN1 APH1A VAV2 APH1B EPHB6 EPHB2 EPHB1 EPHB4 EPHB3 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 ABCA3 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 97%6804760 Regulation of TP53 Activity through Methylation CHEK2 ATM SMYD2-1 MDM2-2 SETD9 TTC5 EP300 RPS27A L3MBTL1 TP53 UBB;UBC PRMT5 KMT5A EHMT2 JMY EHMT1 MDM4 UBA52 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 97%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CCNE2 CCNE1 RB1 CDK2 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells RUNX1 LGALS3 CBFB REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764274 Regulation of Expression and Function of Type I Classical Cadherins CSNK2A1;CSNK2A3 MOGS H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 SEC11A RPN2 SEC11C RPN1 PSMD12 PSMD11 PSMD14 PSMD13 SMARCA4 FOXA2 H2AC20 PSMA7 PSMD8 H2AB2;H2AB3;H2AB1 SRC EZH2 PSMB6 TGIF2 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PIP5K1C PSMB3 PSMD2 PCSK7 SPCS3 PSMD3 ANK3 SPCS2 PSMB1 SPCS1 PSMD1 BANP ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 CTNND1 PSMC6 MTBP PSMA4 RACK1 CBLL1 SIRT1 PSMC3 PSMA1 EPS15 PSMC4 PSMC1 CTNNB1 H2AJ TCF12 CANX PCSK6 TLE1 SUZ12 H2BC5 UBA52 H2BC1 KDM1A DNM2 MPHOSPH8 RPS27A H2AC4 UBB;UBC FOXQ1 DNTTIP1 ZBTB33 FOXP2 ZEB2 KMT5A PKM ZEB1 MCRIP1 FOXJ2 KLF9 TMEM258 MDM2-2 SNAI1 SNAI2 CTNNA1 CDH1 KLF4 OST4 JUP STRAP OSTC STT3A TWIST2 SP1 H2BC21 VCL PRKCSH EED DDOST H2AZ2;H2AZ1 WT1 ARID1A DAD1 GANAB MYC CTSS HDAC2 MYCN HDAC1 TNRC6C MOV10 CSNK2A2 TNRC6A-1 AGO4 RBBP4 AGO2 AGO3;AGO1 ZNF217 TNRC6B CTSB CTSV;CTSL H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 CSNK2B RBBP7 TFAP2A H2BC15;H2BC3;H2BC11;H2BC12 ARHGAP32 FURIN ZMYM2 CTBP2 CTBP1 MAPK1 POMT2 RB1 MAPK3 POMT1 H2AC14 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 97%165054 Rev-mediated nuclear export of HIV RNA NUP133 NUP107 NUP188 RANGAP1 NUP50 POM121;POM121C RCC1 NUP54 NUP210 NUP93 NUP205 NUP42 AAAS XPO1 NUP160 NUP43 NUP85 TPR NUP214 NUP88 RAE1 RANBP2 RANBP1 NUP155 NUP153 NUP35 NUP62 RAN NUP37 NDC1 SEC13 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) NSDHL DHCR24 HSD17B7 LBR DHCR7 CYP51A1 SC5D EBP MSMO1 TM7SF2 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 L3MBTL2 RBBP4 EPC1 MAX CBX5 BRCA1 BMI1 RBBP7 RAD51 RING1 PCGF6 SUZ12 PCGF2 RYBP RNF2 YAF2 CHEK1 EED PHC1 EZH2 CBX3-1 E2F6 APAF1 MGA PHC3 RRM2-1 TFDP1 TFDP2 EHMT2 EHMT1 UXT RBBP8 E2F1 CDC7 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%418890 Role of second messengers in netrin-1 signaling DCC TRPC7 PITPNA PLCG1 TRPC5 NTN1 TRPC6 TRPC3 TRPC4 TRPC1 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 97%69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A TPTEP2-CSNK1E;CSNK1E RBX1 GSK3B CSNK1A1 PSMD12 CHEK2 PSMD11 CHEK1 PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PLK3 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 BTRC PSMC3 PSMA1 PSMC4 PSMC1 SKP1 FBXW11 NEK11 UBA52 CUL1 RPS27A UBB;UBC MAPK14 MAPK11 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932506 DAG1 core M1 glycosylations POMT2 DAG1 POMT1 POMGNT1 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development HDAC1 CALM3;CALM1 CAMK4 TBL1XR1 GPS2 NCOR2 NCOR1 SIN3A PRKACA-1 HDAC3 FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm NOG CREBBP MESP2 PSMD12 NOTCH1 PSMD11 PSMD14 PSMD13 LEF1 RBPJ DLL1 PSMA7 DLL3 BMP4 PSMD8 LFNG PSMB6 PSMB7 MAML2 PSMD6 MAML1 PSMB4 PSMD7 PSMB5 PSMB2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 HES7 MAML3 EPHA4 ADRM1 MSGN1 TBX6 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 SNW1 PSMC6 MAMLD1 PSMA4 RIPPLY2 PSMC3 PSMA1 FGFR1 PSMC4 PSMC1 KAT2B CTNNB1 KAT2A WNT3A EP300 TBXT METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins DPM1 DPM2 DPM3 ARSD-1 N6AMT1 RPL10A IDE RARS1 MRPS17 GFM1 MRPS15 MRPS16 MRPS14 MRPS11 MRPS12 RAB4A MRPL38 MRPL39 MRPS10 MRPL36 GCSH-3 MRPL37 MRPL34 MRPL35 MRPL32 MRPL41 MRPL4 MRPL42 RAB5A MRPL3 RPL36AL-1 MRPL2 MRPL40 MRPL1 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 HMGCS2 MRPS23 IDH3A MRPL49 MRPS18B MRPS21 MRPS2 MRPS18A MRPL47 APOA2 MRPL48 APOA1 MRPS7 APOA4 MRPL46 MRPS6 MRPL43 APOA5 MRPS5 MRPS18C MRPL44 PDHB MRPL52 MRPL53 TTR MRPL50 MRPS9 MRPL51 AURKAIP1 DAP3 MRPL18 MRPS33 MRPS34 RAB14 MRPL19 MRPS31 MRPL16 MRPS35-1 MRPL17 MRPL14 MRPL58 MRPL15 MRPS30 MRPL12 MRPL13 MRPL57 MRPL10 MRPL54 MRPL11 MRPL55 RPL18A MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 PDK1 MRPL24 MRPL21 MRPL22 MRPL30 LOC107987373;MRPL23 SUCLG2 HSP90B1 LHB TXN PRKDC TMEM129 HLTF RNF152 SHPRH PEX10 PEX2 PEX12 PEX13 PEX14 RNF40 RNF144A SELENOS WAC-1 RNF181 INS;INS-IGF2 RAD18 APEH ACOT2;ACOT1 ATP5PF ATP5PD ATP5PO NDUFA13 HADH RPL15-1 ATP5MG IDH2 GLUD1;GLUD2 HK1 DBT TRAPPC2L RAB32 RAB31 TBC1D20 RAB35 RAB38 ALDH1B1 RAB6B TRAPPC3 TRAPPC1 TRAPPC4 TRAPPC5 RAB39A RAB27A RAB39B RAB27B TRAPPC9 UQCRC2 RAB8B TRAPPC2;TRAPPC2B RPL10;RPL10L-1 RAB33A TRAPPC6A TRAPPC6B RAB7B RAB1A RAB1B RAB21 GGA2 GGA1 GGA3 CHML TRAPPC10 GPIHBP1 RAB33B-1 RAB11B RAB10 CS RAB13 RAB18 ARF1 RPLP0 TRMT112 RPLP2 RPL36-1 ARG2 SUMF2 SUMF1 MITF BDH1 DLD VAMP2 FH KARS1 CLSPN GSN MDH2 RPL22L1 RPL37A-1 ACAT1 SRD5A3 MME COX4I1 NADK2 ME2 RPL13A-1 ST6GALNAC5 ST6GALNAC6 NDUFB6 FFAR4 HSD17B10 IARS1 GRP RPL23A ARSA STX1A ARSL ARSJ ARSK ARSH ARSI ST8SIA5 ARSG CTSA RPL27A P2RY2 PCSK1 CDX2 GPR119 GIP DPP4 LEP ACAD8 ANK3 KDM8 OGFOD1 JMJD4 DHPS FN3KRP JMJD7 RCCD1 EIF5A2 DNAJC24 DPH1 DPH2 DPH5 DPH6 DPH7 ZC3H15 FN3K RWDD1 ICMT EIF5A;EIF5AL1 DOHH RIOX1 DRG1 DRG2 CPB2 NDUFV3 NDUFV1 CD59 CD55 DARS1 NDUFS3 MVD NDUFS1 MAT2B MBTPS1 RPL26L1 RPL4 POLB RPL30 RPL3 RPL32 RPL31 PCSK2 RPL34 ERO1B CTSZ KIF5C RPL8 ANPEP CPA3 RPL9 SLC30A8 RPL6 SLC30A5 FSHB RPL7 ATP6AP2 MYRIP GZMH-1 RPL35 ENPEP CPB1 PLA2G7 RPL38 CRHR2 CLTRN ACE IGF1 RPL39 MBOAT4 INHBC INHBE CPE REN RPL21 RPL23 RPL22 SMC5 PARK7 SMC6 DDX17 NSMCE3 FDX1 NSMCE2 RPL24 NSMCE1 HIC1 RPL27 EID3 ZBED1 RPL26 TP53BP1 RPL29 SP3 RPL28 TOP2A TOP2B ZNF131 SENP5 FOXL2 SENP2 SAFB NSMCE4A TOP1 SP100 UHRF2 RNF168-1 CASP8AP2 NOP58 RPL3L RWDD3 MBD1 RAD52 OGDH UBXN1 NGLY1 MLEC RPLP1-2 ENGASE CDH2 RPL11 RPL14 RPL13 RPL18 RPL17 RPL19 USP8 AGT FECH ALB UBE2T RPL7A ADRA2C ADRA2A SARS1 RPL35A FOLR2 OXCT1-1 VDAC1 TFAM-1 TWNK ACADSB STAR SSBP1 QARS1 IGF2 FFAR1 DLAT SEC61A2 B3GNT7 B3GNT5 SEC61A1 B3GNT4 SEC61G SEC61B B3GNT3 PSME1 B3GNT2 SEC22B PSMB10 PSMB8 PSMB9 PPA1-1 ATP5F1A ATP5F1B ATP5F1C OXA1L HSPA9 B4GALT2 B4GALT3 VGF ALDH2 TSHB SPTBN2 MARS1 CTSH B4GALT6 CTSC B4GALT4 B4GALT5 CAPZA3 ACTR10 POMC DCTN6 DCTN5 DCTN4 APP NFKB2 TOMM20 VDAC2-1 SKP2 VDAC3 AARS1 HARS1 YARS1 WARS1 GARS1 NARS1 FARSA CARS1 TARS1 FARSB VARS1 AREG NFE2L2 EEF1B2-1 EEF1G EEF1A1 EEF1D EEF1A2 CEACAM8;CEACAM7;CEACAM6;CEACAM1;CEACAM5-1 EEF2 UCHL1 SENP8 UCHL3 FOXK2 FOXK1 MBD5 MBD6 ASXL1 ASXL2 BAP1 KIF5B KIF5A GATA6 GATA4 ANK1 CAPZB MAN1A2 MAN1C1 MAN1A1 CAPZA1 CAPZA2 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2S2 EIF2S3;EIF2S3B EIF2B1 EIF2S1 HGS DCAF13 RAB7A PSME2 MUL1 ARFGAP1 SRPRB-1 PREB KDELR3 OMA1 HTRA2 GOSR2 MDC1 SSR1 HIF3A DAXX RRAGA IGFBP7 WFS1 BARD1 PRELID1 LONP1 UBXN7 CDKN1A PDIA6 DPP3 CHM BRCA1 SRPRA ING2 BABAM1 BABAM2 UIMC1 ABRAXAS1 BRCC3 DDB2 PCNA WRN RPA1 HIPK2 USP7 IGFBP3 USP2 BLM MDM2-2 NPM1-2 MDM4 DCAF8 DCAF5 DCAF6 WSB2 DCAF4;DCAF4L2;DCAF4L1 COMMD5;LOC101928879 OBSL1 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 COMMD8 COMMD9 PUM2 DDA1 ANKRD9 COMMD2 COMMD3 COMMD1 COMMD6 RABGGTB COMMD7 RABGGTA COMMD4 SPSB3 CCDC8 BIRC5 CUL9 UBD NAE1 SOCS6 SOCS5 AURKB WDTC1 CCDC22 DCUN1D2-1 COMMD10 DTL TULP4 PML DCAF16 DCAF17 CAND1 FEM1C DCAF10 DCAF11 FEM1A TRRAP FEM1B NEURL2 ERCC8 JMJD6 TADA2B PRMT3 H2AC16;H2AC11 KDM1B RUVBL1 ULBP3;ULBP1;RAET1G;ULBP2;RAET1L ATXN7 RIOX2 H2BC18 CALB1 BACE1 MFGE8 APCS CALCA TSPAN33 USP22 CST3 TSPAN5 SNCA ODAM NAT8-2 SNCAIP SORL1 TSPAN15 TSPAN14 SLC35C1 TGFBI ITM2B SLC25A5 SLC25A6 MUC13 CKAP4 KTN1 ADAMTS13 MRTFA TF DYNC1LI1 DYNC1LI2 CDCA8 RHOT1 HNRNPC LRRC41 INCENP GPS1 LMAN1 STX5 YKT6 USP9X MCFD2 SERPINA1 PPP6C PPP6R1 PPP6R3 LMAN1L GORASP1 SEC22A SEC22C NAPB TMED10 STX17 LMAN2L USO1 NAPG LMAN2 SEC31B ANKRD28 SEC23IP CNIH1 CRYZL2P-SEC16B;SEC16B CNIH2 FOLR1 CNIH3 BET1 SPTB ANK2 COPS4 COPS2 SPTBN4 SPTBN5 ARFGAP3 ARFGAP2 SPTA1 DMP1 RNF20 MATN3 TNC CFTR SCFD1 SPTBN1 FBN1 STAM SPTAN1 LAMB2 DYNC1I1 PIAS4 HDAC4 PIAS3 UBE2I THRB VDR NR1H2 RORA NR3C1 RAB9A ESR1 NR2C1 PIAS1 NR3C2 RAB9B NR4A2 NR5A1 AR RXRA SUMO1 SUMO3 SUMO2 RARA PGR PPARG PPARA TP53 STAM2 STARD7 CSNK2A2 CSNK2B ACHE SENP1 CSNK2A1;CSNK2A3 ALPG;ALPP;ALPI-1 BMI1 YY1 RING1 BCHE SATB1 RNF2 HDAC7 CBX8 PHC2 PHC1 CBX4 CBX2 PHC3 PNPLA2 NAGK AMDHD2 GFPT2 GFPT1 PGM3 CETN2 GNPNAT1 UAP1 CCP110 RENBP OTUD7B PRKACA-1 ACTR1A TNFAIP3 TUBA1A USP21 USP4 BTRC CYLD RAB8A BIRC2 SKP1 BIRC3 CDC73 LEO1 FBXW11 CSNK1D AXIN2 TUBA4A UBA52 DYNC1I2 DCTN2 DCTN3 CUL1 AURKA CSF1 MAN2A2 MGAT3 ST8SIA6 CHST8 CAMKMT ST8SIA2 FUCA1 ST8SIA3 RPS27A UBB;UBC DYNC1H1 TUBB4B TUBB4A;TUBB;TUBB8B;TUBB8 TNIP2 CDK1 STAT3 ADAM10 HSPG2 ADAMTS16 NCSTN ADAMTS18 PLAUR LAMC1 ADAMTS4 ADAMTS5 GALNT2 ADAMTS1 KLK3;KLK2 CTSG TIMP1 ADAMTS8 CTSD ADAMTS9 FOXO4 ATXN3 MMP1 MMP2 OTUB2 OTUD5 OTUD7A FBXO32 VCPIP1 TNIP3-2 ZRANB1 YOD1 RNF128 TNIP1 OTUB1 FURIN PLG SPP1 CMA1 LAMB1 H2AC14 TRIM28 L3MBTL2 TGFA HCFC1 SATB2 OGT-1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 PPARGC1A CREBBP NPPA SMAD2;SMAD3 ADRB2 H2AC20 H2AB2;H2AB3;H2AB1 NCOA1 NCOA2 ACTL6A UBE2D3-1 NCOR2 KAT2B KAT2A SUZ12 H2BC5 MCRS1 PCGF2 H2BC1 TTF1 IGFBP1 EP300 MEN1 H2AC4 DNMT1 SUDS3 CBX5 PENK ACTB-1 TADA3 KLF4 CHD3 SIN3A PARP1 H2BC21 ZNF350;ZNF432 DNMT3B WDR5 DNMT3A H2AZ2;H2AZ1 KCTD6 SMAD1 SMAD4 SMURF2 SMAD7 HDAC2 HDAC3 THBS1 HSPD1 HDAC1 MTA1 RBBP5 TDG H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 RBBP7 PROS1 H2BC15;H2BC3;H2BC11;H2BC12 FGA FGG F2 NOTUM F5 F7 F8 LYZ-1 F9 SERPINC1 KNG1 SERPIND1 F10 FUCA2 PROC EIF2AK2 TOPORS POMT2 SEMA5A SPON2 SEMA5B SPON1 THSD7B POMT1 ADAMTSL3;ADAMTSL1 ADAMTSL1 C1GALT1C1 ADAMTS2 LTF ADAMTS3 ADAMTSL5 ADAMTSL4 ADAMTSL2 MUC12 THSD7A MUC15 ADAMTS6 ADAMTS7 SBSPON MUC3A MUC5AC ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 BPIFB2 MUC1 MUC2 ADAMTS19 ADAMTS17 MUC7 MUC4 MUC6 PSMD12 GALNT3 MUC17 PSMD11 C1GALT1 MUC5B PSMD14 MUC20 PSMD13 MUC21 DNAJC3-1 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 SRP14 PSMB5 PSMB2 PSMB3 PSMD2 PALB2 PSMD3 PSMB1 PSMD1 ADA2 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 AHSG PSMC3 PSMA1 PSMC4 PSMC1 CTNNB1 RAB3D RAB44 PCCB RAB37 RAB4B RAB24 NUP214 COPB1 HSPA8 PABPC1;PABPC3 EIF4G1 ASPH RBX1 QSOX1 SLC35A1 SLC35A4 FKRP B4GAT1 CRPPA CHST10 DAG1 RXYLT1 LARGE1 LARGE2 POMGNT1 FKTN GNAT3 ADORA2B FCGR3A;FCGR3B CUL3 KBTBD7 USP18;USP41 C3-1 SAA2;SAA1 NUP107 NUP188 USP14 NUP210 NUP93 NUP205 ABCE1 AAAS NUP160 NUP85 ARRB1 TPR NUP88 NUP155 XRCC4 USP17L22;USP17L12;USP17L21;USP17L25;USP17L24;USP17L26;USP17L29;USP17L5;USP17L30;USP17L28;USP17L27;USP17L20;USP17L19;USP17L15;USP17L11;USP17L18;USP17L17;USP17L13;USP17L10;USP17L3;USP17L1;USP17L4;USP17L8;USP17L7;USP17L2-2 NUP153 RCE1 NAPA RARS2 AARS2 RAB5C PARS2 TGOLN2 MARS2 DARS2 HARS2 YARS2 ELOC-1 FARS2 WARS2 NUP62 LARS2 SARS2 ELOB NARS2 TARS2 IARS2 VARS2 CARS2 EARS2 NDC1 LIPT2 SEC13 NFU1 LIPT1 NUP133 LIAS PIGS CPM LY6K PIGU GOLGB1 PGAP1 RANGAP1 PIGT NUP50 SFTPB POM121;POM121C PSCA SFTPC PIGO PIGN NUP54 CSF2RB GPAA1 CSF2RA PIGP PIGZ MSLN PIGW PIGV PRSS21 PRND TECTB IZUMO1R RTN4RL2 CISH PIGC PIGB NUP42 PRL NRN1L RTN4RL1 CD109 PIGA SOCS2 LY6D PIGK NUP43 PIGM SPACA4 TAF9B PIGL RAE1 PIGG LY6H RANBP2 PIGF GPLD1 PIGH NRN1 NTM TEX101 TAF10 LYPD1 LYPD2 LYPD3 LYPD4 THY1 LYPD5 ART3 LYPD8 NUP35 ARRB2 ART4 OTOA LY6G6C OPCML NTNG1 NTNG2 NEGR1 CNTN5 NUP37 PIGX-1 LSAMP COP1 GP2 PLET1 PRSS41 XPNPEP2 LYPD6B ALPL VCAN CNTN3 MELTF GLB1 CNTN4 TECTA;TBCEL-TECTA MDGA2 RECK MDGA1 SPRN ARSB DDX58 SRP19 TRAM1 UBE2L6 SRP54 SSR4 SSR2 IFIH1 SSR3 SRP9 TRIM25 SRP72 SRP68 IKBKG LRR1 CCNF KEAP1 HERC2 GALNT11 GALNT14 AMER1 GALNT13 GALNT16 FBXO7 AXIN1 GALNT15 FBXO9 GALNT18 B3GALNT2-2 GALNT10 POFUT2 WSB1 FBXO2 EMID1 GALNT9;GALNT17 RNF123 FUT10 APC FUT11 GALNTL5 UBE2J2 GALNTL6 B3GNTL1 GALNT9 GALNT8 SPG7 POMGNT2 B3GNT9 SIAH2 B3GNT8 MMRN1 SIAH1 AFG3L2 B3GNT6 MMRN2 SMDT1 CHST4 YME1L1 FBXL8 GCNT1 FBXL4 GCNT3 FBXL7 PMPCA GCNT4 MICU2 GALNT7 GALNT6 GALNT5 GALNT4 MGAT5B-1 A4GNT POMK GAN PRKN GATA3 EIF5 GPR75-ASB3;ASB3-1 KLHL2 RAB2A KLHL3 UBE2G1 UBE2G2 KLHL9 SPSB2 SPSB1 KLHL5 EIF5B KBTBD8 SPSB4 FBXO27 LTN1 UBE2Z FBXO21 FBXO22 BMP4 FBXW12 FBXW8 UBE2E3 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 KLHL42 UBE2V2 HIF1A CUL7 CUL5 UBA6 MYC CUL2 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2F UBE2H UBE2B KLHL25 ALG5 ZBTB16 NUDT14 TGFB1 KLHL21 KLHL22 BTBD6 FBXO30 KLHL20 FBXO31 UBE2W UBA3 TFAP2C UBA1 UBE2K TFAP2E;TFAP2B KBTBD13 UBE2Q2 GMPPB FPGT UBE2D1 RELA GMPPA GFUS DHRSX GMDS PMM1 FCSK UBE2R2 DOLPP1 TCF7L2 ALG10;ALG10B GFM2 CDKN2A MTRF1 UBE2C ASB13 MTRF1L ASB14 UBE2E1 MRRF ASB11 IL6 GOSR1 UBE2S RNF7 ASB12 ASB17 RCHY1 ASB18 FBXL22 ASB15 ASB16 COG8 FBXL20 COG7 ZDHHC2 COG6 RPS15 COG5 RPS14 COG4 COG3 ASB10 RPS17 COG2 BET1L RAB30 RPS16 RAB36 FBXL19 RPS19 FBXL18 FBXL15 RPS18 APOL3;APOL4;APOL1;APOL2 FBXL16 FBXL13 FBXL14 RPS11 FBXL12 B2M RPS10 ASB8 RPS13 ASB9 RPS12 ASB6 ST6GAL1 ASB7 MOGS ASB4 ACE2 ASB5 ASB2 RPN2 SAR1B ASB1 SDC2 RPN1 ST3GAL4 GOLGA2 CDC25A ST3GAL1 ST3GAL2 C12orf65 ST3GAL3 MIEF1 MALSU1 MTFMT EDEM2 MTIF2 MTIF3 MTRES1 GRIA1 RPS25 RPS27 RPS29 RPS20 NSF RPS21 RPS24 RPS23 ADORA2A MAGT1 IKBKE TOMM70 RIPK2 SFTPD ANO8 MYO5A CANX RPS27L RNF135 RPS15A MGAT5 RPS3 GPC3 MGAT1 RPS2 MGAT2 KLK13 SEC24D-1 FAU VCP-1 TUSC3 MAP3K7 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA OTULIN TUFM TMEM258 DDX5 FUT8 MAN2A1 NLRP3 HLA-C;HLA-B;HLA-A;HLA-G;HLA-F;HLA-E OST4 MAVS OSTC USP30 SQSTM1 STT3A UBE2N ZNF598 ASCC2 ASCC3 STT3B TAB1 ST6GALNAC2 TRIM27 USP10 PRKCSH USP13 TNKS MGAT4A-1 RPS4X TNKS2 RNF146 OTUD3 RPS3A DDOST DAD1 TRAF3 TIMM17A-1 TRAF6 CHCHD2 ST6GALNAC1 OPA1 CMAS OXSM ECH1 MAN1B1 NPL NANP ST6GALNAC3 TIMM22 NEU4 ST6GALNAC4 CLPX BECN1 ST8SIA4 CLPP NANS SEC23A TIMM10 LDHD ST6GAL2 NOD1 ST8SIA1 ALDH18A1 GNE NOD2 GANAB EIF4A2 EIF4A1 VHL SEC24B SEC24A GALNT1 MGAT4C KDELR2 MGAT4B COPB2 COPA SEC24C COPE EIF4E EIF4B TMED3 TMED7 TMED9 COPZ2 COPZ1 CALM3;CALM1 ARF5 DCAF7 CCT6B ARCN1 PFDN4-1 COPG2 GNGT1 COPG1 TUBA1C KIF13A TUBB1 FBXO4 METTL21A LONP2 FBXO6 KIN RGS9 METTL22 ETFBKMT RGS6 RGS7 VCPKMT FAM86B1;EEF2KMT;FAM86B2 CCT3 FBXW4 EEF1AKMT2 CCT2 EEF1AKMT1 FBXW10;CDRT1 FBXW5 TUBB2B;TUBB2A VBP1 FBXW7 SPHK1 FBXW9 FBXW2 CCNE2 CCNE1 TCP1 XRN2 GAPDHS PFDN1 PFDN2 FKBP9 PFDN5 TUBB3;TUBB6 PFDN6 TUBAL3 GBA ARL2 GNA14 AP3M1 PSMD9 GNG10 GNA15 PSMD4 GNG2 PSMD5 GNG5 PAAF1 GNG4 PSME3 GNA11 PSME4 GNG8 PSMD10 PSMB11 CCT8 TUBA3E;TUBA3C-1 POMP PSMA8 CCT7 PSMF1 CCT5 PSMG3 CCT4 NOP56 PSMG4 ARFGEF2 PSMG1 PSMG2 TBCD TBCC TBCB TBCA USP5 GNG13 USP3 CCT6A GNAQ FKBP8 GNB2 SNX3 PAX6 TBCE USP37 GNB1 USP34 PDCL USP47 GNB4 IAPP USP48 GNB3 USP49 SKIV2L USP42 FBXL3 USP44 PTRH2 GNB5 USP26;USP29 RGS11 ARF4-1 FBXL5 USP16 WDR20 TUBA8 WRAP53 USP24 USP25 USP20 USP28 B4GALT1 TMED2-1 CALU SEL1L ST3GAL6 RAB6A SPP2 EXOC8 EXOC7 APLP2 SCG3 EXOC4 RHOA EXOC3 EXOC6 EXOC5 EXOC2 EXOC1 GBF1 EPAS1 RAB11A SOCS3 ANKZF1 KLHDC10 NPLOC4 TCF25 UFD1 NEMF UBA2 SAE1 VNN1 LTBP1 VNN2 APH1A APH1B INHBB INHBA CHRDL1 PSENEN MIA2 UCHL5 MIA3 TMEM115 USP15 FSTL1 FSTL3 INHA U2AF2 TPGS1 TTL TPGS2 SVBP ARPC4-TTLL3;TTLL3 TTLL12-1 AGTPBP1 LRRC49 NICN1 VASH2 VASH1 AGBL5 TTLL7 AGBL4 TTLL6 SMC3 TTLL5 TTLL4 RAD21 AGBL1 AGBL3 TTLL1 AGBL2 STAG1 TTLL11 TTLL9 STAG2 SMC1A NRIP1 TRAF2 RIPK1 CDC34 NFRKB BCL10 ACTR5 RAD23A UBE2D3;UBE2D2 ACTR8 NFKBIA RAD23B DDB1 INO80C INO80B INO80E INO80D COPS7B COPS7A XPC TFPT INO80 TGFBR1-1 CUL4A COPS3 TGFBR2 COPS6 COPS5 COPS8 CUL4B PCSK9 FGF23 SLC34A2 SLC34A1 P4HB APOB ISL1 CDC20 GSPT2 GSPT1 CCNA2-1 CCNA1 USP33 ETF1 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4EBP1 EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H LARS1 EIF3E EIF3F EIF3D EIF3A EIF3B SHMT2 JOSD2 JOSD1 COL7A1 RAB3A DLST RPL12-1 EDEM3 AMFR SYVN1 DERL2 EDEM1-1 RNF5 RNF103 OS9 RNF139 TRIM13 UGGT2 UGGT1 RNF185 MARCHF6 ABRAXAS2 TPST2 MYSM1 STAMBPL1 TPST1 STAMBP IL33 UQCRQ ACO2 ALAS1 PTEN FN1 ETFB UMOD ASGR1 ASGR2 MANEA LY6E ALG8 ALG9 LGALS1 ALG6 AMELY;AMELX ALG2 ALG3 EVA1A ALG1 CCN1 CHGB IGFBP5 IGFBP4 IGFBP2 SHISA5 PAPPA MXRA8 SPARCL1 IGFALS SCG2 KLK1 STC2 IGFBP6 AMBN ECI1 DHDDS TMEM132A HRC PRSS23 BMP15-1 STS MEPE RCN1 ENAM AMTN VWA1 FAM20C FAM20A PAPPA2 ITIH2 AFP GOLM1 PPA2 NUCB1 CES1 TFG NEU2 NEU3 CTBP1 NAPSA WDR61 CCDC59 PGA4;PGA3;PGA5 NEU1 ADGRF5 LMCD1 APOE HNRNPK B4GALNT2 WDR48 GAS6 AIMP1 BST1 AIMP2 EPRS1 RAB5B RAB22A RAB40C RAB3B RAB3C SEC11A RAB42 SEC11C RAB2B RAB34 PTP4A2 RAB20 RAB25 RAB26 RAB23 RAB29 COG1 RAB15 RAB19 RAB17 MSRA PCMT1 EEF1E1 MSRB3 MRPS36 COX5B COX5A SPCS3 SPCS2 SPCS1 ALG14 ALG12 ALG11 GCG NDUFAB1 RFT1 LOC110384692;C4A;C4B_2;C4B ABCA3 PMM2 CP CALR-1 GGCX PDHA1 KDELR1 CTR9 RTF1 SEC31A PAF1 DERL1 DPAGT1 MPI DOLK DCTN1 ST3GAL5 CGA RPL5-1 MPDU1 FUT6;FUT5;FUT3 NUS1 SLC17A5 PDIA3 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 97%8878166 Transcriptional regulation by RUNX2 AKT2 AKT3 HIVEP3 WWTR1 YES1 ITGBL1 SATB2 PPARGC1A MAF PPARGC1B IHH PSMD12 MSX2 PSMD11 HDAC6 PSMD14 PSMD13 PSMA7 BMP2 PSMD8 SRC RBM14 PSMB6 PSMB7 PSMD6 ESRRA PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 PSMA1 PSMC4 PSMC1 SKP1 DLX5 AKT1 UBA52 WWP1 STAT1 CUL1 CCNB1 CDK4 RPS27A UBB;UBC GLI3 GLI2 CDK1 ABL1 RBX1 ZNF521 GSK3B COL1A1 HDAC4 SOX9 UCMA HEY1 TWIST2 HEY2 NR3C1 ESR1 AR SMAD1 SMAD4 SMURF1 SMAD6 HDAC3 HES1 BAX DLX6 CCND1 CBFB RUNX1 MMP13 SP7 NKX3-2 HAND2 ITGA5 PPM1D YAP1-1 MAPK1 RB1 MAPK3 STUB1 LGALS3 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 97%9711123 Cellular response to chemical stress MED1 P4HB AKT2 AKT3 CSNK2A1;CSNK2A3 MAP1LC3B2;MAP1LC3B-1 SOD3 ATOX1 CCS COX7B ABCF2-H2BE1;ABCF2 PGD PRDX3 CREBBP COX7C PRDX6 PSMD12 NOTCH1 PSMD11 COX8A PSMD14 PSMD13 COX8C PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 SRXN1 PSMB4 PSMD7 TXNIP GPX6 CAT PRKCI GPX5 COX5B PSMB5 GPX8 PSMB2 SKP2 PRDX2 GPX7 PSMB3 PSMD2 PALB2 ALB COX5A EGF PSMD3 PRDX1 PSMB1 PSMD1 ADRM1 NCOA1 NCOA2 TXNRD2 PSMC2-1 NCOA6 PSMA2-1 PSMA5 SEM1 GPX1 COX6C UBXN7 PSMA6 PSMC5 PSMA3 PDGFA PSMC6 MAFK PSMA4 AREG BTRC NFE2L2 CDKN1A PSMC3 PSMA1 DPP3 PSMC4 NCOR2 PSMC1 SKP1 BRCA1 COX6A1 COX6A2 NCOR1 TXN2 CCL13;CCL2 EIF2AK3 TXNRD1 G6PD AQP8 AKT1 COX6B2 UBA52 KEAP1 COX6B1 PRKCD ATF4 STAP2 CUL1 NOX4 PTK6 NPLOC4 AMER1 GSTP1 TRIM21 GCLC UFD1 GCLM CHD9 CYCS-1 EP300 VCP-1 RPS27A UBB;UBC TBL1XR1 SESN2 FABP1 BLVRB TXN HELZ2 BLVRA RBX1 STAT3 MAFG BCL2 BCL2L1 NLRP3 GSK3B SQSTM1 TGS1 CHD6 SP1 SIN3A RXRA CARM1 PPARA COX4I1 HBD;HBB COX4I2 HBA2;HBA1 ME1 CYBB CYBA CUL3 MYC COX7A2L-1 SMARCD3 HDAC3 CSNK2A2 PRKAA2 NQO1 HMOX1 HMOX2 CSNK2B ABCG2 IDH1 COX7A2 GSTA3;GSTA1 NCF1 NCF2 NCF4 RELA SOD2 TALDO1 SOD1 NOX5 NDUFA4 TKT ATP7A CDKN2A ERO1A FBXL17 BACH1 SESN1 NFKB1 MUL1 HM13 SLC7A11 NUDT2 ABCC3 ABCC1 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling STAT1 TYK2 STAT2 IL19 PTPN11 STAT5A STAT3 STAT5B IL10RB IFNLR1 IL20RA IL20RB IL22RA2 IL22RA1 IFNL2;IFNL3;IFNL1 IL22 JAK1 STAT4 IL20 JAK2 IL26 IL24 JAK3 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME DATABASE ID RELEASE 97%177539 Autointegration results in viral DNA circles PSIP1 BANF1 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 97%191859 snRNP Assembly GEMIN4 NCBP1 GEMIN5 NUP133 GEMIN6 SNRPF SNRPD2 GEMIN7 SNRPD1 GEMIN8 NUP50 POM121;POM121C SNRPB SNRPD3 NUP54 PHAX NUP42 TGS1 NUP43 SNRPE-2 RAE1 RANBP2 CLNS1A SNUPN NCBP2-1 NUP35 DDX20 NUP37 SNRPG-2 NUP107 NUP188 WDR77 SMN2;SMN1 NUP210 PRMT5 NUP93 NUP205 AAAS NUP160 NUP85 NUP214 TPR NUP88 NUP155 NUP153 GEMIN2 NUP62 NDC1 SEC13 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs TNRC6C TNRC6A-1 AGO4 AGO2 AGO3;AGO1 TNRC6B FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 97%9935598 FXIIa, PKa activate coagulation factors GP1BA GP5 GP9 KLKB1 F9 KNG1 F12 GP1BB F11 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 97%9012546 Interleukin-18 signaling IL18BP IL4 IL18RAP ALOX5 IL13 IL37 IL18 IL18R1 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 97%5173214 O-glycosylation of TSR domain-containing proteins ADAMTS2 ADAMTS3 ADAMTS1 ADAMTSL5 ADAMTSL4 ADAMTSL2 THSD7A ADAMTS8 ADAMTS6 ADAMTS7 ADAMTS9 SBSPON ADAMTS20 B3GLCT ADAMTS12 CFP THBS2 THSD1 THSD4 ADAMTS10 ADAMTS15 ADAMTS14 ADAMTS19 ADAMTS17 ADAMTS13 ADAMTS16 POFUT2 ADAMTS18 SEMA5A SPON2 SEMA5B SPON1 THSD7B ADAMTSL3;ADAMTSL1 ADAMTS4 THBS1 ADAMTSL1 ADAMTS5 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 97%169911 Regulation of Apoptosis PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 PSMC3 PSMA1 PSMC4 PSMC1 PAK2 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 OPA1 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 ARHGAP10 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 OMA1 SEM1 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG PLA2G4A LPCAT4 CRLS1 PLA2G1B PLA2R1 LPGAT1 LPCAT1 PLA2G3 PLA2G5 PLA2G2A-1 PLA2G10;LOC100652777 PLA2G2F PLA2G12A PLA2G4F PLA2G2D JMJD7-PLA2G4B;PLA2G4B PLA2G2E PLA2G4D RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.4 RNA Polymerase III Transcription Initiation From Type 1 Promoter POLR3GL POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3H POLR3K POLR2E POLR2F POLR2H POLR2L TBP BDP1 GTF3C1 GTF3C2 GTF3C3 GTF3C4 POLR1C GTF3C5 POLR1D BRF1 GTF3A GTF3C6-1 CRCP INDUCTION OF CELL-CELL FUSION%REACTOME DATABASE ID RELEASE 97%9733458 Induction of Cell-Cell Fusion ANO9 ANO6 TMPRSS2 ANO4 FURIN ANO5 ACE2 ANO2 ANO10 ANO3 ANO1 ANO8 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network FGF20 FGF23 INSR TGFA PIK3R3 PIK3R6 AKT2 PIK3R5 AKT3 IRS2 LCK SRC PIP5K1A PIP5K1B PIP5K1C EGF ERBB2 EGFR PDGFRA FGF6 HGF GAB1 PPP2R1A MET AREG RAC1 NRG1 NRG2 FGF7 EREG BTC FGF22 FGF3 FGF10 NRG3 NRG4 HBEGF KIT NTRK3 AKT1 NTF3 PPP2CB;PPP2CA PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B RHOG PPP2R5E VAV1 IER3 FLT3LG PDGFB CD19 CD28 STRN GAB2 PHLPP2 PHLPP1 IL33 CD86 FGF2 IRAK1 KLB CD80 PDGFRB INS;INS-IGF2 FGF19 FGFR4 IL1RL1 TRAT1 FLT3 PIK3AP1 ESR1 THEM4 PIP4K2A PIP4K2B PTEN PIP4K2C PIK3CD TRAF6 PIK3CG IRS1 PIK3R2 ESR2 PIK3CB PIK3R1 FYN FRS2 PIK3CA MYD88 PTPN11 IRAK4 EPGN NTRK2 BDNF TRIB3 MAPK1 MAPK3 FGF1 FGF4 FGF16 FGF9 FGF18 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%8849472 PTK6 Down-Regulation PTPN1 SRMS PTK6 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 97%192823 Viral mRNA Translation RPS14 RPS17 RPS16 RPS19 RPS18 RPL22L1 RPS11 RPL10A RPS10 RPL37A-1 RPS13 RPS12 RPL26L1 RPL4 RPL30 RPL3 RPL32 RPL31 RPL34 RPL27A RPL8 RPL9 RPL6 RPL7 RPS4X GRSF1 RPL35 DNAJC3-1 RPL38 RPS3A RPL10;RPL10L-1 RPL39 RPS25 RPS27 RPS29 RPS20 RPS21 RPL21 RPS24 RPL23 RPS23 RPL36AL-1 RPL22 RPL7A RPL24 RPL13A-1 RPL27 RPL26 RPL29 RPL28 RPL15-1 RPLP0 RPLP2 RPL36-1 RPL35A RPL3L RPL5-1 RPS27L RPS15A RPS3 RPLP1-2 UBA52 RPS2 RPL18A RPL23A FAU RPL12-1 RPS27A RPS9 RPS7 RPS8 RPL11 RPS5 RPL14 RPS6 RPL13 RPL18 RPSA RPL17 RPL19 RPS15 KINESINS%REACTOME%R-HSA-983189.5 Kinesins KIF18A KIF18B KIF12 KIF11 KIF15 KIF19 KIF13B KIF1C KIF1B KIF3A KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIF2A KIF5B KIFC2 KIF5A KIFC1 KIF21A KIF21B KIFAP3 KIF2C KIF4B;KIF4A KIF2B KIF16B KIF20A KIF20B KLC1 CENPE KLC4 KIF26A KLC3 KLC2 KIF26B RACGAP1 KIF3B KIF3C NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes ATF4 TXN MAFK NFE2L2 NQO1 HMOX1 GCLC GCLM SRXN1 EP300 TXNRD1 BACH1 SOD3 PRDX1 SLC7A11 CREBBP CHD6 GSTA3;GSTA1 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum NOTCH1 NOTCH2 NOTCH3 NOTCH4 POGLUT1 POFUT1 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R FGF20 FRS2 GAB1 SOS1 FGF23 FLT3LG PIK3CA PTPN11 AKT2 GAB2 IRS4 TLR9 FGF2 KLB FGF7 PDE3B FGF22 FGF3 FGF10 FGF19 FGFR4 IRS2 FLT3 IGF1R PIK3R4 THEM4 IGF2 PDPK1 IGF1 TRIB3 IRS1 PIK3C3 PIK3R2 PIK3CB HRAS PIK3R1 FGF1 FGF6 FGF4 FGF16 NRAS FGF9 FGF18 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 97%211859 Biological oxidations PTGIS NR1H4 FMO1 FMO2 UGP2 ALDH1B1 FMO3 CYP26A1 N6AMT1 ADH1C;ADH1B;ADH1A TPMT UXS1 AHR AS3MT PTGES3-1 ABHD10 GSTA3;GSTA5;GSTA1;GSTA2 GSTK1 ACY3 AIP BPNT1 POMC CYP4F22 AHCY ESD CYP2C18-1 GSTM4 GSTM3 AKR1A1 CYP2J2-1 NCOA1 NCOA2 CYP2B6 CYB5R3 UGT1A1;UGT1A6 CYP8B1 GLYATL3 SULT1C2 SULT1B1-1 ACSS2 CYP46A1 TRMT112 GSTO2 GSTT2B;GSTT2 ACSS1 GSTO1 GGT1 AKR7A2 AKR7A3 MAT1A BPHL DPEP2 DPEP1 CYP21A2 CYP51A1 CYP11A1 ACSM1 ACSM5 SULT6B1 MTR-1 GGT5 ACSM4 MTRR NNMT GGT7 CHAC2 GGT6 CHAC1 GSTP1 GCLC GCLM PTGS1 GLYAT CMBL CYP27A1 SULT4A1 CYP2F1 ABHD14B POR CYP2U1 NAT1 GSTM1;GSTM2-1 ACY1;ABHD14A-ACY1 MAOB MTARC2 SLC35D1 MAOA PODXL2 TPST2 MTARC1 MGST3 SLC35D2 AADAC TPST1 MGST1 MGST2 CYP26B1 CYP27B1 PAOX MAT2B GSTT1 MAT2A HPGDS CYP2S1 CYP24A1 SULT2A1-4 CYP7B1 CYP19A1 UGDH TBXAS1 HSP90AB1 FDXR RXRA CYP1B1 CYP7A1 GGCT CYP11B1;CYP11B2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CBR3 UGT2A1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ARNT FDX1 CYP2W1 GSTA4 ADH5 COMT CNDP2 ADH4 ARNT2 NQO2 ACSM2A;ACSM2B CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP4B1 ALDH3A1 GSTZ1 CYP1A1 CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2E1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 GSTA3;GSTA1 EPHX1 BPNT2-1 CYP39A1 AHRR CES3 CES2 OPLAH CES1 ALDH2 CYP2R1 CYP2A13;CYP2A6;CYP2A7-1 CYP4V2 ALDH1A1 GSS AOC3 AOC1 AOC2 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 RBX1 PSMC3 PSMA1 PSMC4 PSMC1 SKP1 TACC3 AKT1 UBA52 PSMD12 PSMD11 PSMD14 PSMD13 CUL1 YWHAZ PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 RPS27A PSMD7 PSMB5 PSMB2 PSMB3 UBB;UBC PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 NOTCH4 PSMC2-1 PSMA2-1 PSMA5 SEM1 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC STARD7 CSNK2A2 ABHD3-2 CSNK2A1;CSNK2A3 PHOSPHO1 CSNK2B CHAT CEPT1 BCHE CHKB CHKA STARD10 PEMT SLC44A5 ACHE CHPT1 SLC44A3 LPIN1 LPIN2 SLC44A4 LPIN3 SLC44A1 SLC44A2 LPCAT1 PCTP PCYT1B PCYT1A MFSD2A LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival GNG10 GNAS-1 GNG2 ADCY9 GNG5 GNG4 PRKAR1B PRKAR1A GNG8 YES1 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 CD163 ADCY5 PLK2 GNG13 RHBDF2 PRKACB-1 MYH9 GNB2 PRKAR2A GNB1 GNB4 GNB3 ITPR1 ADAM17 ITPR2 GNB5 ITPR3 CD3G CYSLTR1 CYSLTR2 GNAT3 SYK FGR HCK ADORA2B GNAI1 GNAZ PLCG1 GNAI3 GNAI2 FCGR3A;FCGR3B FYN FCGR1A PRKACA-1 PLCG2 GGT1 CALM3;CALM1 DPEP2 DPEP1 LYN IL10 GNGT1 GGT5 FURIN PRKAR2B AHCYL1 IL6 PRKX MAPK14 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 97%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta TBK1 DHX58 TKFC PCBP2 MAVS CREBBP PIN1 HSP90AB1 ITCH APP TAX1BP1 RNF125 NFKB2 IRF3 TRAF3 TRAF6 ATG12-1 IRF7 ATG5 IKBKE TOMM70 NLRX1 AGER S100A12 IFNB1-4 TNFAIP3 NFKBIB SAA2;SAA1 UBE2D3-1 NKIRAS1 NKIRAS2 CYLD TRAF2 CHUK CASP8 HSP90AA1 SIKE1 UBA7 DDX58 RIPK1 NLRC5 ISG15 UBE2L6 CASP10 HMGB1-1 FADD HERC5 MAP3K1 IFIH1 RNF135 IKBKB OTUD5 TRIM25 IKBKG UBE2D3;UBE2D2 UBA52 NFKBIA UBE2K UBE2D1 TANK RELA RNF216 EP300 RPS27A UBB;UBC NFKB1 G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69615 G1 S DNA Damage Checkpoints TPTEP2-CSNK1E;CSNK1E RBX1 MDM2-2 CCNA2-1 CCNA1 GSK3B CSNK1A1 MDM4 PSMD12 CHEK2 PSMD11 CHEK1 PSMD14 CDC25A PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PHF20 PSMD6 ZNF385A PSMB4 PSMD7 PSMB5 PSMB2 TP53 PSMB3 PSMD2 PSMD3 PCBP4 PSMB1 PSMD1 ADRM1 COP1 PLK3 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 ATM PSMA3 PSMC6 PSMA4 CDKN1A BTRC PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 SKP1 FBXW11 NEK11 UBA52 CUL1 CDK2 RPS27A CDKN2A UBB;UBC CCNE2 MAPK14 CCNE1 MAPK11 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2485179 Activation of the phototransduction cascade GNGT1 GNAT1 CNGB1 PDE6B PDE6A RHO GNB1 CNGA1 SLC24A1 SAG P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69580 p53-Dependent G1 S DNA damage checkpoint MDM2-2 CCNA2-1 CCNA1 MDM4 PSMD12 CHEK2 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PHF20 PSMD6 ZNF385A PSMB4 PSMD7 PSMB5 PSMB2 TP53 PSMB3 PSMD2 PSMD3 PCBP4 PSMB1 PSMD1 ADRM1 COP1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 ATM PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 UBA52 CDK2 RPS27A CDKN2A UBB;UBC CCNE2 CCNE1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 97%418592 ADP signalling through P2Y purinoceptor 1 GNB3 PLA2G4A GNGT1 P2RY1 GNB5 GNA14 GNG10 GNA15 GNG2 GNG5 GNG4 GNA11 GNG8 MAPK14 GNG13 GNAQ GNB2 GNB1 GNB4 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol CYP27A1 AMACR SLC27A2 SLC27A5 AKR1D1 CYP39A1 CYP46A1 ABCD3 HSD3B7 LIPOPHAGY%REACTOME DATABASE ID RELEASE 97%9613354 Lipophagy HSPA8 PLIN2 PRKAB1 PRKAB2 PRKAA2 PRKAG1 PLIN3 PRKAG3 PRKAG2 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 97%3595177 Defective CHSY1 causes TPBS BCAN VCAN DCN CSPG5 CHSY1-1 NCAN BGN GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977443 GABA receptor activation KCNJ2 KCNJ12;KCNJ18 KCNJ3 GABRQ KCNJ4 GABRA2 GNG10 GABBR2 GABRA1 GNG2 KCNJ5 ADCY9 GNG5 GABBR1 GNG4 KCNJ6 KCNJ10 GNG8 GABRA6 GABRA5 KCNJ9 GABRA4 ADCY4 GABRA3 ADCY3 KCNJ15 KCNJ16 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNAT3 GNAI1 GNAI3 GNAI2 GNAL GNGT1 GABRB3 GABRB2 GABRB1 GABRR3 GABRR2 GABRR1 GABRG3;GABRG2 NPTN ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) PTPN11 TBK1 TANK TICAM2 LY96 TICAM1 IRF3 OPTN-1 TRAF3 RPS27A IRF7 CD14 UBB;UBC TLR4 IKBKE UBA52 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.7 NOTCH1 Intracellular Domain Regulates Transcription HDAC1 HES1 SNW1 MAMLD1 RBX1 HDAC10 NCOR2 SKP1 KAT2B CDK8 KAT2A NCOR1 HES5 HDAC11 TLE4 TLE2 TLE1 HDAC4 CCNC-1 HEY1 HEY2 CREBBP HDAC5 HDAC8 UBA52 HDAC9 NOTCH1 HDAC6 HDAC7 NBEA CUL1 RBPJ HEYL MAML2 EP300 MAML1 RPS27A UBB;UBC TBL1XR1 MAML3 HIF1A MYC HDAC2 HDAC3 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes MSH2 FANCD2 CDK7 FANCI FANCC CTDP1 MNAT1 POLR2A POLR2B POLR2C MDC1 ATF2 POLR2D POLR2G POLR2I CHEK1 SSRP1 TCEA1 TP53 GTF2H2C;GTF2H2C_2;GTF2H2 JUN ATM CDK12 CDK13 ATR CCNK CCNT1 BRCA1 SUPT16H POLR2E POLR2F GTF2F1 POLR2H GTF2F2 POLR2L FOS DDB2 RAD51D ERCC3 ERCC2 PMS2 GTF2H1 SUPT4H1-1 GTF2H3 GTF2H4 MLH1 SUPT5H CDK9 POLR2J;POLR2J2;POLR2J3 CCNT2-1 ELL ELOC-1 ELOA NELFB ELOB CCNH NELFCD NELFA NELFE IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%451306 Ionotropic activity of kainate receptors DLG3 DLG4 CALM3;CALM1 DLG1 GRIK5 GRIK3 GRIK4 NCALD GRIK1 GRIK2 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 EIF2S2 EIF2S3;EIF2S3B RPS10 EIF2S1 RPS13 RPS12 RPS27L RPS15A EIF3C;EIF3CL RPS3 EIF1AY;EIF1AX EIF3M EIF3K EIF3L RPS2 EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F RPS4X EIF3D EIF3A EIF3B RPS3A FAU RPS25 RPS27A RPS27 RPS29 RPS20 RPS21 RPS24 RPS9 RPS23 RPS7 RPS8 RPS5 RPS6 RPSA RPS15 SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 97%4791275 Signaling by WNT in cancer PPP2R1A CTNNB1 RNF43 GSK3B WNT3A CSNK1A1 TNKS TNKS2 AMER1 PPP2CB;PPP2CA AXIN1 FZD5 PPP2R5B FZD4 PPP2R5A TCF7L2 PPP2R5D FZD6 PPP2R5C FZD8 PPP2R1B KREMEN1 APC PORCN PPP2R5E KREMEN2 CTBP2 CTBP1 DKK1 DKK2 DKK4 LRP5 LRP6 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296059 G protein gated Potassium channels GNB3 KCNJ2 GNGT1 KCNJ12;KCNJ18 KCNJ3 GNB5 KCNJ4 GABBR2 GNG10 KCNJ5 GNG2 GABBR1 GNG5 KCNJ6 GNG4 KCNJ10 GNG8 KCNJ9 KCNJ15 KCNJ16 GNG13 GNB2 GNB1 GNB4 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 97%187577 SCF(Skp2)-mediated degradation of p27 p21 CCNA2-1 CCNA1 CKS1B PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMD8 PSMB6 PSMB7 PSMD6 PSMB4 PSMD7 PSMB5 PSMB2 SKP2 PSMB3 PSMD2 PSMD3 PSMB1 PSMD1 ADRM1 PSMC2-1 PSMA2-1 PSMA5 SEM1 PSMA6 PSMC5 PSMA3 PSMC6 PSMA4 CDKN1A PSMC3 CDKN1B PSMA1 PSMC4 PSMC1 SKP1 CCND1 UBA52 CUL1 PTK6 CDK4 CDK2 RPS27A UBB;UBC CCNE2 CCNE1 RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation RAB38 RAB30 RAB36 RAB5B RAB6B RAB2A RAB22A RAB40C RAB3B RAB3C RAB42 RAB39A RAB2B RAB34 RAB27A PTP4A2 RAB39B RAB20 RAB27B RAB9A RAB25 RAB26 RAB23 RAB29 RAB9B RAB15 RAB19 RAB17 RAB8B RAB4A RAB33A RABGGTB RAB7B RABGGTA RAB1A RAB5A RAB1B RAB21 CHML RAB6A RAB33B-1 RAB11B RAB10 RAB13 RAB18 RAB8A CHM RAB3D RAB44 RAB7A RAB37 RAB4B RAB24 RAB14 RAB11A RAB3A RAB5C RAB32 RAB31 RAB35 COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 97%166658 Complement cascade C1S CFD C3-1 MASP1 CD19 CFB C4BPA C4BPB VTN LOC110384692;C4A;C4B_2;C4B PROS1 C1QB CPB2 CRP CD81 COLEC10 C1R C5AR2 FCN2;FCN1 CFI F2 C5AR1 C8B C8A CPN2 C2 CPN1 CR1L;CR1 C5 SERPING1 CLU C8G C6 C7 C3AR1 C9 CD59 CD55 MBL2-1 CR2 CFHR1;CFHR2 CFH-3 ELANE C1QC COLEC11 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 97%4839735 Signaling by AXIN mutants PPP2R1A AMER1 PPP2CB;PPP2CA AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C PPP2R1B APC PPP2R5E GSK3B CSNK1A1 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 97%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates CYP2S1 CYP2D6;LOC107987479;LOC107987478-1 CYP4B1 CYP4F22 CYP2U1 CYP4F3;CYP4F2;CYP4F12;CYP4F11 CYP2W1 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%72649 Translation initiation complex formation RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 EIF3C;EIF3CL EIF1AY;EIF1AX EIF4H EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F RPS4X EIF3D EIF3A EIF3B RPS3A RPS25 RPS27 RPS29 RPS20 RPS21 RPS24 RPS23 EIF4A2 EIF4A1 EIF4E EIF2S2 EIF4B EIF2S3;EIF2S3B EIF2S1 RPS27L RPS15A RPS3 RPS2 FAU RPS27A RPS9 RPS7 PABPC1;PABPC3 RPS8 RPS5 RPS6 EIF4G1 RPSA RPS15 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 97%210745 Regulation of gene expression in beta cells FOXA3 GCK FOXA2 AKT2 AKT3 SLC2A2 HNF4G FOXO1-1 INS;INS-IGF2 NEUROD1 NKX6-1 NKX2-2 PDX1 PAX6 HNF1A MAFA RFX6 AKT1 IAPP SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer FGFR3 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655332 Signaling by FGFR3 in disease FRS2 FGF20 GAB1 SOS1 PIK3CA FGF23 FGFR3 FGF2 PLCG1 HRAS PIK3R1 FGF1 FGF4 FGF16 NRAS FGF9 FGF18 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 97%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins CCDC88C DVL1 DVL2 DVL3 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8951911 RUNX3 regulates RUNX1-mediated transcription RUNX3 CBFB MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 97%1221632 Meiotic synapsis STAG2 SMC1A ATR ACD TINF2 SYCP1 BRCA1 H2AJ SYNE2 TERF2 SYNE1 H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 POT1 SUN1 TERF2IP TEX12 TERF1-1 SMC1B SYCP3-2 LMNB1 SYCE2 FKBP6 SYCE1 H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 UBE2I HSPA2 H2BC15;H2BC3;H2BC11;H2BC12 REC8 H2BC5 STAG3 SYCP2-1 H2BC21 H2BC1 SUN2 H2AC20 H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 H2AC4 SMC3 RAD21 H2AC14 STAG1 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 97%191650 Regulation of gap junction activity GJA1 TJP1 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-HSA-9634635.4 Estrogen-stimulated signaling through PRKCZ MAPK1 HRAS PDPK1 PRKCZ NRAS DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 97%5632968 Defective Mismatch Repair Associated With MSH6 MSH2 MSH6 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GNB3 GNGT1 GNB5 GNG10 GNG2 GNG5 GNG4 PLCB3 GNG8 PLCB1 PLCB2 GNG13 GNB2 GNB1 GNB4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%500792 GPCR ligand binding TAS2R3-1 S1PR1 TAS2R16 DRD1 CCL3L1;CCL3L3;CCL3;CCL18 DRD2 DRD3 DRD4 DRD5 POMC TAS2R40 TAS2R41 APP TAS2R39 ADORA2A ADORA3 ADORA1 TAS2R45;TAS2R43;TAS2R31;TAS2R46;TAS2R30;TAS2R50;TAS2R19;TAS2R20 WNT3A PRH1-TAS2R14;TAS2R14-3 LHB TAS2R7 TAS2R8 OPN1MW3;OPN1MW2;OPN1MW;OPN1LW GRM4 TAS2R1 TAS2R4 C3AR1 TAS1R2 TAS1R1 TAS1R3 GNGT1 GLP1R SST GNG10 RAMP2 GABBR2 GNG2 GABBR1 GNG5 GNG4 GNG8 GNG13 IHH GNB2 GNB1 ADM IAPP GNB4 CHRM2 GNB3 CHRM4 ADRB1 ADRB2 GNB5 HTR4 HTR6 HTR7 HRH3 HRH2 CALCRL HRH4 HTR1E TAAR8 TAAR9 MCHR1 HTR1F TAAR6 HTR1D HTR1A TAAR5 HTR1B TAAR2 HTR5A TAAR1 ADRB3 SCT RXFP4 MRGPRD FZD10 RXFP1 RXFP2 RXFP3 CRHBP CMKLR1 AGTR2 FPR1 SSTR3 GHRHR GALR3 GALR2 GALR1 NPBWR1 NPBWR2 WNT10B WNT10A FZD9 GPR183 PNOC MC4R GPR18 EDNRB RHO PTH1R EDN1 UCN3 EDN3 GPR37 GPR35 PTH2R RGR MC3R PLPPR1 PLPPR2 PLPPR3 MC1R PLPPR4 MC5R PLPPR5 WNT8A WNT8B NPFFR2 NPFFR1 P2RY12 NPFF HCRT P2RY13 PF4;PF4V1-1 P2RY14 QRFPR WNT7B QRFP GPR55 HCRTR2 SCTR HCRTR1 WNT7A ADM2 MTNR1A MTNR1B CALCB;CALCA RLN3 ECE1 PRLHR INSL3 INSL5 P2RY4 ADCYAP1 APLN ECE2;EEF1AKMT4-ECE2 ADCYAP1R1 VIPR1 VIPR2 RRH PTGDR GPR37L1 KEL TAS2R42 ADRA2B GIPR CRHR1 NLN PENK PPY CRH PTGDR2 NPY4R2;NPY4R OXGR1 GPBAR1 GAL OPRD1 PTGER4 NPB RAMP3 PTH PTGER2 PTGER3 NPW RLN2;RLN1 PRLH MAS1 XK GHRH HCAR1 HCAR2;HCAR3 RAMP1 NPY2R NPY NPY1R APLNR SUCNR1 WNT6 CALCR WNT2 WNT3 OPN3 OXTR PTCH2 GRPR OPN5 EDNRA PYY PROK2 PROK1 UTS2R WNT2B ADGRE1 TRHR GRM3 OPRM1 UTS2B HEBP1 AGTR1 GRM2 PTGFR ADGRE5 LPAR1 GRM7 LPAR2 GRM6 CXCL12 LPAR3 GPER1 FPR2 ADGRE3 LPAR4 GRM8 NTSR1 NTSR2 GPR17 PTGIR NMB NPY5R XCR1 OPRK1 XCL1;XCL2 GLP2R NMBR SSTR1 LPAR5 SSTR2 LPAR6 WNT16 NMS SSTR4 NMU SSTR5 GNRH1 MLN OPRL1 BRS3 PTHLH GPRC6A CNR2 GPR132 CNR1 CCKAR GNRHR S1PR3 FFAR4 FFAR2 S1PR2 S1PR5 GPR39 S1PR4 EDN2 ANXA1 TACR2 TACR3 ACKR1 TACR1 VIP CCKBR NPSR1 GRP F2R PTGER1 F2 PTAFR NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 OXT-1 GPR143 KNG1 F2RL1 F2RL2 CCR6 F2RL3 CHRM1 CCR2 GPR68 GPR65 CHRM5 PMCH GHSR CASR LTB4R2 NTS MCHR2 HRH1 TAC3 TAC1 OPN4 NMUR2 NMUR1 MLNR HTR2B HTR2A TRH LTB4R GRM1 GRM5 BDKRB2 BDKRB1 CALCA P2RY6 P2RY2 P2RY1 CCK KISS1 FFAR3;GPR42 GIP GCGR C5AR2 C5AR1 C5 CD55 GNAS-1 SMO ADRA1D PTCH1 ADRA1B ADRA1A TBXA2R FSHB SHH CYSLTR1 CYSLTR2 ADORA2B OPN1SW C3-1 SAA2;SAA1 MC2R CCR5 WNT9A AGT CHRM3 AVPR2 CXCR4 WNT5A WNT1 FZD1 FZD3 FZD2 FZD5 FZD4 FZD7 PSAP FZD6 FZD8 GCG CXCL9 ADRA2C CXCL8 CXCL13 ADRA2A CX3CL1 CCRL2 CCR9 CXCL5;CXCL6 CCR8 CCR7 CCR4 CCR3 CXCL2;CXCL3;CXCL1-1 CCL13;CCL2 CCL11 CXCR5 CXCR6 CCL4L2;CCL4L1;CCL4 CXCR1 CXCR3 CCL5 CXCR2 CCL1 CCL19 DHH CCL17 CCR10 CCL16 CCR1 CCL25 CCL22 CCL21 CCL20 PPBP CXCL10 CXCL11 ACKR4 ACKR2 CCL28 CCL27 ACKR3-2 LHCGR FSHR GPHA2 TSHR GPHB5 WNT11 WNT4 WNT9B PDYN FFAR1 CENPS-CORT;CORT;CENPS CGA CX3CR1 AVPR1B AVPR1A AVP TSHB HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022928 HS-GAG biosynthesis SLC35D2 EXT1 EXT2 NDST2 NDST1 NDST4 NDST3 GPC1 SDC4 GPC3 SDC2 GPC2 SDC3 GPC5 GPC4 HS3ST5 HSPG2 GPC6 HS3ST6 HS3ST4 HS3ST1 HS3ST2 HS6ST1 HS3ST3A1 HS6ST2 HS6ST3 EXTL2 AGRN SDC1 HS2ST1 HS3ST3B1 EXTL3 GLCE INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 97%2995383 Initiation of Nuclear Envelope (NE) Reformation CDK1 PPP2R1A LBR CCNB2 EMD CCNB1 PPP2CB;PPP2CA SIRT2 LEMD3 BANF1 ANKLE2 KPNB1 LMNB1 VRK1 LEMD2 PPP2R2A;PPP2R2D WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 97%3238698 WNT ligand biogenesis and trafficking WNT9A WNT16 VPS29 VPS35 WNT10B WNT10A WNT11 WLS WNT3A VPS26A WNT4 SNX3 TMED5 WNT5B WNT9B WNT5A WNT1 WNT8A WNT8B WNT6 WNT2 WNT7B WNT3 PORCN WNT7A WNT2B ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 97%9034864 Activated NTRK3 signals through RAS SOS1 NTF3 HRAS NTRK3 NRAS PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection ABL1 ARPC4 ARPC5 WAS ARPC2 ARPC3 YES1 ACTB-1 NCKAP1L MYO9B NCK1 MYH9 ACTR2 ARPC1B ARPC1A WASL ACTG1 CD3G CDC42 SYK FGR HCK FCGR3A;FCGR3B FYN WASF2 WASF3 BAIAP2 NCKIPSD RAC1 MYO10 BTK MYO5A MYO1C ABI2 ELMO1 ABI1 ELMO2 CRK DOCK1 LYN PTK2 ACTR3-1 CYFIP2 CYFIP1 NCKAP1 VAV3 WASF1-1 WIPF1 WIPF2 WIPF3 VAV1 VAV2 MAPK1 MAPK3 DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 97%4043916 Defective MPI causes CDG-1b MPI ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029485 Role of phospholipids in phagocytosis ITPR1 PRKCD ITPR2 PIK3CA ITPR3 PRKCE PLPP5 PLPP4 PLCG2 CD3G AHCYL1 SYK PIK3R2 PIK3CB PLCG1 PLD4 PIK3R1 FCGR3A;FCGR3B FCGR1A PLD1 PLA2G6 PLD3 PLD2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDK4 CDKN2A GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins PROC F2 F7 GGCX FURIN F9 PROS1 F10 GAS6 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 97%209776 Metabolism of amine-derived hormones DDC TPO DUOX1 CGA DUOXA1 DUOXA2 DBH AANAT TXNDC11 DUOX2 PNMT IYD DIO1 CAV1 DIO3 SLC5A5 TSHB TH TPH2 TPH1 ASMT NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 97%8863678 Neurodegenerative Diseases JUN GOLGA2 CDK5R1 CDC25A CDC25B BCL2L11 APP SOD2 FASLG FOXO3 CDK5 PRDX2 CAPNS1 CAPNS2 PRDX1 LMNB1 YWHAE CAPN2 CAPN1 CAST CDC25C SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654688 SHC-mediated cascade:FGFR1 FGF20 SOS1 FGF23 FGF2 FGF22 FGF3 FGF10 HRAS FGF1 FGF6 FGF4 NRAS FGF9 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis HOXC4 HOXA2 PBX1 PAXIP1 CNOT6 YY1 DPY30 POLR2A H3C10;H3C8;H3C6;H3C1;H3-4;H3C3;H3C4;H3C7 POLR2B PAGR1 POLR2C PAX6 CREBBP POLR2D CTCF H2BC21 POLR2G POLR2I CNOT9 WDR5 RXRA KDM6A H2AC20 EED RARA H2AB2;H2AB3;H2AB1 H2AZ2;H2AZ1 EZH2 HOXB4 ASH2L NCOA6 NCOA3 HDAC3 JUN RARG RBBP4 RBBP5 H2AJ H2BC8;H2BC6;H2BC4;H2BC10;H2BC7 NCOR1 POLR2E RARB POLR2F POLR2H RBBP7 HOXA3 POLR2L HOXA1 PKNOX1 HOXA4 PIAS2 HOXB3 H2BC15;H2BC3;H2BC11;H2BC12 HOXB2 SUZ12 HOXB1 H2BC5 AJUBA HOXD1 PCGF2 MEIS1 H2BC1 MAFB HOXD4 HOXD3 ZNF335 POLR2J;POLR2J2;POLR2J3 EP300 EGR2 H2AC4 KMT2D KMT2C H2AC14 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 97%9656256 Defective OGG1 Substrate Processing OGG1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 97%168179 Toll Like Receptor TLR1:TLR2 Cascade S100A8 TLR2 DUSP4 DUSP3 TIRAP VRK3 DUSP6 DUSP7 ATF2 SOCS1 APP NFKB2 TLR6 CD36 RIPK2 JUN PPP2R1A MAPK7 BTRC SKP1 ECSIT CHUK BTK FBXW11 IKBKB IKBKG FOS UBA52 CUL1 MAPKAPK2 PPP2CB;PPP2CA PPP2R5D ATF1 RPS27A ELK1 RPS6KA3 PPP2R1B S100A1 RPS6KA5 RPS6KA2 UBB;UBC RPS6KA1 MAP3K7 MAP3K8 MEF2A MAP2K3 MAPK14 MAP2K4 MEF2C MAPK11 MAPKAPK3 MAPK9 MAPK8 MAP2K7 MAPK10 TNIP2 UBE2V1 MAP2K6 IRAK1 IRAK2 UBE2N TAB3 TAB2 TAB1 TRAF6 TP53 NOD1 NOD2 ALPK1 NLRX1 AGER S100A12 N4BP1 USP18;USP41 MYD88 NFKBIB SAA2;SAA1 NKIRAS1 NKIRAS2 LY96 IKBIP IRAK4 TRAF2 PELI1 CASP8 LRRC14 USP14 PELI3 PELI2 NLRC5 CD14 TIFA HMGB1-1 TLR4 MAP3K1 SIGIRR IRAK3 FGB NFKBIA FGA FGG RELA NFKB1 MAP2K2;MAP2K1 MAPK1 MAPK3 TLR1 S100A9 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 97%912526 Interleukin receptor SHC signaling SOS1 PIK3CA PTPN6 PIK3R3 IL3RA IL2RB GAB2 INPPL1 CSF2RB CSF2RA INPP5D IL5RA SHC1-1 JAK2 CSF2 IL2 IL3 PIK3CD PIK3R2 PIK3CB IL5 IL2RA PIK3R1 IL2RG JAK1 JAK3 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript CPSF1 NCBP1 NUP133 CPSF3 NUP107 NUP188 NUP50 POM121;POM121C NUP54 EIF4E SYMPK NUP210 NUP93 FIP1L1 NUP205 NUP42 AAAS NUP160 NUP43 NUP85 TPR NUP214 NXF1 NUP88 RAE1 RANBP2 NUP155 NUP153 ALYREF NCBP2-1 CPSF2-1 NUP35 NUP62 NUP37 WDR33 NDC1 CPSF4 SEC13 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000157 Laminin interactions HSPG2 LAMA5 ITGA1 ITGA3 LAMA3 ITGB1 ITGA7 LAMA2 ITGA6 LAMA4 ITGA2 NID1 LAMB3 LAMB2 ITGB4 ITGAV LAMB1 LAMA1 NID2 COL18A1 LAMC3 LAMC2 LAMC1