LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway ACE REN AGT ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway KDR THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD FH DLST PDHB DHTKD1 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway HPRT1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway HSP90AA1 NR3C1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId CMPK1 SLC2A1 NME2 LALBA G6PC1 SLC35A2 B4GALT1 GALT UGP2 CANT1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway TRAF3 TRAF6 IKBKG CD40 MAP3K1 CHUK DUSP1 ELP1 TNFAIP3 MAPK14 NFKB1 IKBKB NFKBIA CD40LG INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway ACE REN AGT STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS D2HGDH PC GLUD1;GLUD2 SUCLG2 ACO1 L2HGDH SUCLG1 ACO2 DLD FH DLST PDHB DHTKD1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway CBR3 ABCG2 CBR1-1 NQO1 ABCC1 ABCC2 ABCB1 NOS3 RALBP1-1 AKR1A1 POR SLC22A16 NDUFS7 NDUFS3 NDUFS2 XDH CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling GLUD1;GLUD2 HAL SDS CPS1 GLDC AQP8 DLD AMT ASNS GLUL ASRGL1 GLS2 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages PRKCB ITPR1 PLCB1 PRKCA CACNA1D CACNA1F RELA MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS MAPK3 CACNA1C NFKB1 NFKBIA CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway CACNB1 ABCC8 INS;INS-IGF2 SLC2A2 CACNA1A CACNA2D2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE CMAS GFPT1 HEXA DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD AMBRA1 PIK3R1 PIK3C2A EGFR FIG4 INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP5K1A PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis ODC1 SMS AMD1 MAT2B SRM MAT2A ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism ACE REN AGT MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation LDHD HAGH GLO1 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 EPHX1 CYP1A2 HYOU1 CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 CYP2E1 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 NQO1 COMT PDIA2 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis CMPK1 SLC2A1 NME2 LALBA G6PC1 SLC35A2 B4GALT1 GALT UGP2 CANT1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 GDA DPYD ITPA CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) ACADL ACADS HADH ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 QARS1 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 RETSAT RDH8 RDH12 AWAT1 RDH11 LRAT ADH1C;ADH1B;ADH1A BCO1 DGAT1 DHRS3 RPE65 DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway ACE REN AGT DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 GDA DPYD ITPA CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis TYR DCT PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism HGD TAT PAH FARSA YARS1 HPD FARSB FAH GSTZ1 IL4I1 GOT1-1 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway ACE REN AGT INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone GNGT1 GNB1 PRKACB-1 CREB1 FSHR ADCY2 CGA GNAS-1 PPP1CA AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency PNMT DDC TH GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism GLYAT ACSM1 ACSM2A;ACSM2B PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle AQP1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) PTPMT1 GPD1 AGPAT5-1 CRLS1 CDS2 PGS1 GPAM GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway ABCC2 SLC22A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2D6;LOC107987479;LOC107987478-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms PER1 NPR1 CRY1 TPTEP2-CSNK1E;CSNK1E CLOCK CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins TUB CHRM1 GNAQ GNGT1 GNB1 PLCB1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine RPL4 RPL30 RPLP1-2 RPL3 RPL32 FARSA RPL31 RPL34 RPLP0 FARSB RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway ACE REN AGT GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease GPI PGAM1 PGAM2 BPGM ENO1 HK2 GAPDH-1 ALDOA GALM-2 PGK1 G6PC1 PFKM PKLR SLC2A2 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC1 CYP2E1 ABCB1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 ABCG2 GSTP1 GSTT1 ABCC4 ABCC5 SULT2A1-4 PDIA2 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation PCCA PCCB DBT SDS DLD BCKDHA BCKDHB MMUT METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 ADH1C;ADH1B;ADH1A CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine AARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 ABCC3 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PLA2G2A-1 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain ATP5PB ATP5MC2 ATP5F1C ATP5F1D CYCS-1 GAPDH-1 ATP5F1A SLC37A4 SDHC ATP5F1B SDHD GPD2 SDHA UQCRC1 SDHB SLC25A4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism NQO1 VKORC1 GGCX LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway SCN1B SCN10A CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism HLCS ACACB BTD SPCS1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway ACE REN AGT OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism HK1 G6PC1 GALE AKR1B1 GLB1 GAA LCT GLA B4GALT1 GALT UGP2 PGM1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway CYP2E1 ALDH3A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ADH1C;ADH1B;ADH1A HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism ACADS HMGCL HADH ECHS1 ACAT1 ACSM1 OXCT1-1 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway MVK MVD FDFT1 HMGCS1-1 HMGCR LSS SQLE ACAT1 FDPS IDI1 PMVK BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis CDIPT PGS1 GPAM PTPMT1 GPD1 JMJD7-PLA2G4B;PLA2G4B CRLS1 CDS1 DGKA CHAT GDE1 LYPLA1-1 AGPAT1 PLD2 PTDSS2 PTDSS1 PLA2G2D PCYT1A CHKA PISD PLA2G15 PHOSPHO1 PEMT PLPP1 GPD2 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway CFD C5 C6 C7 C9 C3-1 CFP C8A CFB NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides SOD2 SOD3 SOD1 TYRP1 CAT NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 TOP1 ABCB1 CES2 CES1 PDIA2 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 VKORC1 FGB FGA F10 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway ACE REN AGT WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway RPS6KA1 PTPN6 GRB2 PLCG1 JAK2 SOS1 SHC1-1 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 HRAS STAT5A MAPK3 STAT5B INS;INS-IGF2 IRS1 INSR SLC2A4 GHR SOCS1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct SLC14A2 SLC4A1 SCNN1G ATP1B3-1 AQP2 AQP3 ATP6V1B1 SCNN1D REN SCNN1B CA1 SCNN1A FXYD2;FXYD6-FXYD2 ATP1B2 ATP1A4 ATP1B1 ATP1A3 ATP1A2 ATP1A1 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle GPD1 GAPDH-1 GPD2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine VARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) RB1 PRKDC FAF1 FASLG LMNB2 LMNB1 MAPK8 PAK1 CASP7 CASP8 CASP10 CASP6 CASP3 ARHGDIB LMNA FADD MAP3K7 PAK2 SPTAN1 MAP2K4 DFFB JUN DFFA DAXX PARP1 RIPK2 CFLAR PTPN13 FAS MAP3K1 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway TUBB1 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC1 ABCC2 ABCB1 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I PC MPC1 GPT AARS2 AGXT HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway ACE REN AGT FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 VKORC1 FGB FGA F10 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 GPX1 DNAJB11 PTGIS ERP29 CYP2J2-1 PPIB SDF2L1 EPHX2 ALOX15 HSPA5 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 HYOU1 CBR1-1 LTC4S CYP2C9;CYP2C19 ALOX15B PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PTGDS GGT1 PTGES PTGS2-2 SLC22A8 SLC22A6 PDIA2 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule SLC38A4 SLC7A5 SLC7A6 SLC7A7 SLC7A8 AQP1 SLC7A9 CA1 SLC4A4 SLC9A1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway PTPN6 GRB2 PLCG1 JAK2 SOS1 SHC1-1 JUN MAP2K2;MAP2K1 RAF1 HRAS STAT5A EPO MAPK3 FOS ELK1 EPOR MAPK8 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway OPRM1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP2D6;LOC107987479;LOC107987478-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway ACE LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development HOPX SRF GATA4 NKX2-5 GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency UPB1 ALDH2 DPYD AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell ADCY10 VAMP2 RAPGEF4 GNG2 GNAQ GNB1 PLCB1 ABCC8 CHRM3 CACNA2D2 PRKCA CACNB1 GLP1R SLC2A2 RAB3A CACNA1A ITPR3 CAMKK1 RIMS2 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin HTR6 GNGT1 GNB1 PRKACB-1 CREB1 GNAS-1 PPP1CA METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway OPRM1 GRIN1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GRIN2A PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism AHCY MARS1 SLC39A8 METTL6 MAT2B SCLY GGT1 SEPHS2 PAPSS1 CBS;CBSL MAT2A CTH GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 PTGDR GNGT1 GNB1 PRKACB-1 ADCY2 GNAS-1 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway ACE STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria HGD TAT PAH FARSA YARS1 HPD FARSB FAH GSTZ1 IL4I1 GOT1-1 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling GNG2 ROCK1 GNB1 ITPR1 AKT1 LPAR4 PLCB1 ADCY1 GNAS-1 SRF NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE CMAS GFPT1 HEXA ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism THTPA TPK1 NTPCR SLC19A2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency SLC25A20 CROT PEX11G CRAT PEX13 PEX14 ABCD2 ACSL1 ABCD1 CPT2 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2B1 STS SRD5A1 HSD17B1 HSD17B3 ARGININEMIA%PATHWHIZ%PW000183 Argininemia GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease ASL ADSL ASNS ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA IL4I1 ABAT ASS1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway ALDH2 ACSS1 ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A CAT HGD MAOA HAAO MIF DBH TYR CYP2E1 COMT ALDH1B1 FAH GSTZ1 DCT ACSS2 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism PC MPC1 GPT AARS2 AGXT MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III UGDH GALE UXS1 GALK1 GALT GCK UGP2 PGM1 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway PRKCA PLCG1 AKT1 PLCB1 PIK3CG PIK3R6 VAV1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging NMNAT2 PPARGC1A SIRT1 NQO1 NADK NPR1 CLOCK NMNAT1 NAMPT NMNAT3 RORA CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 ALAS1 GUSB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin HTR7 GNGT1 GNB1 PRKACB-1 CREB1 GNAS-1 PPP1CA PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway HSP90AA1 NR3C1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SLC22A8 PTGS2-2 SLC22A6 PDIA2 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 SLC6A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B4 ATP1B1 CACNB1 PRKAR1B UQCR11 DLG1 PRKAR1A PRKAR2B KCNQ1 PRKAR2A PRKACB-1 KCNK1 MCU SLC9A1 ALG10;ALG10B SNTB1 SNTB2 GNAS-1 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway PCSK2 CYP1A2 CHRNA4 SLC6A2 CYP2C9;CYP2C19 ADRA1A SLC6A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway CHRNB2 CHRNA3 AOX1 CYP2A13;CYP2A6;CYP2A7-1 CHRNA4 FMO3 CYP2B6 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis SHMT1 TMLHE SETD7 BBOX1 ALDH9A1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency GPD1 GLYCTK PLPP1 AKR1B1 ALDH3A1 AGPAT1 GPD2 LIPC LPL GPAM PLPP2 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA ABCC4 ABCC5 SLC29A1 SLC28A3 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway NME2 AK1 AK2 NME1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA ABCC4 ABCC5 SLC29A1 SLC28A3 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism LDHA GCLM MPST CTNS CDO1 CARS1 GOT1-1 GCLC CTH MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway GRB2 PLCG1 PRKCB SOS1 SHC1-1 STAT6 JAK1 STAT1 EGF STAT2 STAT3 PRKCA RASA1 CSNK2A1;CSNK2A3 MAP2K2;MAP2K1 RAF1 HRAS MAPK3 MAPK8 MAP2K4 JUN EGFR MAP3K1 FOS ELK1 SRF FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) CBS;CBSL CTH VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism PDXK PNPO PDXP ALPL AOX1 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway ACE REN AGT PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 MARS1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway TYMP TYMS CES1 CDA SLC28A1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism TYR FLAD1 RFK ENPP1 ACP1 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 PCSK2 CHRNA4 HYOU1 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PDIA2 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids ACADL ACADS HADH ACSS3 HSD17B10 ECHS1 ACAA2 ACAT1 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis PLPP1 AGPAT1 GNPAT AGPS CEPT1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency PAPSS2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway ACE REN AGT CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway HRH2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 PTGS2-2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 PTGS1 ADH1C;ADH1B;ADH1A ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway NME2 AK1 AK2 NME1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation FXYD2;FXYD6-FXYD2 TREH ATP1B2 SLC5A1-1 ATP1A4 ATP1B1 ATP1A3 ATP1A2 ATP1B3-1 ATP1A1 SLC2A2 GCK PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway MAOA MAOB CYP2D6;LOC107987479;LOC107987478-1 AOX1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle GLUD1;GLUD2 GPT SLC38A4 GPT2 SLC1A4 SLC25A22 SLC2A2 SLC2A4 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway RRM1 CMPK1 RRM2-1 CTPS1 TYMS DCK NME1 NT5C DCTD RRM2B SLC29A1 SLC28A1 SLC28A3 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect MPC1 IDH3B DLAT GPI IDH3A G6PD SLC1A5 PGAM2 TALDO1 PGD ENO1 PDHA1 HK2 IDH3G RPIA GAPDH-1 IDH1 PFKL PGLS SDHC SDHD SDHA TKT SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 ACO1 SUCLG1 ACO2 DLD SLC2A2 PKLR MDH1 LDHA SLC16A1 PKM ALDOB PGK1 FH DLST PDHB DHTKD1 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway ACE TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE CMAS GFPT1 HEXA BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE CMAS GFPT1 HEXA KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) SC5D CYP51A1 DHCR24 MSMO1 HSD17B7 DHCR7 LBR NSDHL EBP ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway MTOR MAPK1 TYK2 JAK1 STAT3 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway BCHE OPRM1 CES2 CES1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway RAC1 CYCS-1 VAV3 BAD SMAD4 APAF1 FOXO4 RALA-1 PLD1 RHOA CDC42 CASP9 MAP2K2;MAP2K1 PIK3CA SMAD2;SMAD3 BCL2L1 CHUK AKT1 RAF1 RALGDS RALBP1-1 HRAS MAPK3 ELK1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis HSD3B1;HSD3B2 CYP11B1;CYP11B2 CYP11A1 AGTR1 GNG2 CYP21A2 GNAQ GNB1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis PNMT DDC TH ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway ABCG2 ABCB1 EGFR NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria LDHA GCLM MPST CTNS CDO1 CARS1 GOT1-1 GCLC CTH ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway ITGB3 ITGA2B BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway ACE LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling GNG2 ROCK1 GNB1 ITPR1 AKT1 PLCB1 ADCY1 LPAR5 GNAS-1 SRF MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) GLP1R SLC10A2 GPBAR1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling GRB2 SOS1 SHC1-1 MAP2K2;MAP2K1 MAPK1 AKT1 RAF1 HRAS PIK3CG PIK3R6 INS;INS-IGF2 IRS1 INSR PDPK1 SLC2A4 FOXO1-1 MAPK8 IRS2 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine LARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked SLC25A20 CROT PEX11G CRAT PEX13 PEX14 ABCD2 ACSL1 ABCD1 CPT2 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway ITGB3 ITGA2B GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2RY12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System DRD1 PRKACB-1 ADCY2 GNAS-1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway EPHX1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway CDKN1A PCNA GADD45B CCNB1 CCND1 CDK4 CCNE1 CDK2 BCL2 CDK1 E2F1 BAX APAF1 RB1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway CFD C5 C6 C7 C9 C3-1 C8A C1QB CFB C1S C1R C2 MBL2-1 SERPING1 MASP2 MASP1 LOC110384692;C4A;C4B_2;C4B C1QC MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway PSMD13 PSMA7 PSMB6 PSMB7 PSMB4 PSMB5 PSMD4 PSMB2 PSMB3 UBD PSMB1 UBB;UBC UBE2E1 PSMC2-1 PSMA2-1 PSMA5 PSMA6 PSMA3 PSMC5 PSMA4 PSMC6 PSMA1 PSMC3 PSMC4 PSMC1 STUB1 UBA1 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura GPD1 GLYCTK PLPP1 AKR1B1 ALDH3A1 AGPAT1 GPD2 LIPC LPL GPAM PLPP2 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism CYP2E1 CYP1A2 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 XDH ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary TPI1 HK1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway PPP3CB PPP3CC BLNK RAC1 GRB2 PLCG1 LYN SYK PRKCB NFATC3 SOS1 NFATC2 SHC1-1 NFATC1 CALM3;CALM1 NFATC4 BTK ORAI1 PRKCA MAP2K2;MAP2K1 RAF1 HRAS MAPK3 VAV1 MAPK8 JUN MAP3K1 FOS ELK1 CD79B PPP3CA CD79A LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling GNG2 ROCK1 GNB1 ITPR1 AKT1 PLCB1 ADCY1 LPAR1 SRF PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism HMGCL BDH1 ACAT1 OXCT1-1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism ASL ADSL ASNS ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA IL4I1 ABAT ASS1 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis PCYT2 PISD PEMT CEPT1 PCYT1A CHKA HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis CASP7 GZMH;GZMB-1 ENDOG HMGB2 CASP3 HMGB1-1 TOP2A DFFA CAD GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway ITGB3 ITGA2B CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA ADCY10 PRKAR1B PRKAR2B PRKAR1A GNGT1 PRKAR2A GNB1 PRKACB-1 GNAS-1 PRKACA-1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A KARS1 RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C2 LOC110384692;C4A;C4B_2;C4B C5 C1QC C6 C7 C9 C3-1 C8A C1QB C1S C1R GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway CACNB1 ABCC8 INS;INS-IGF2 SLC2A2 CACNA1A CACNA2D2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism NMNAT2 NADK AOX1 PNP-1 NNMT QPRT NADSYN1 ENPP1 BST1 NNT NT5C2 NMRK1 NUDT12 NAMPT SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 ALAS1 GUSB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 ALAS1 GUSB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway ACE ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 PTGS2-2 TOP2B ABCC3 PDIA2 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 SLC22A1 CRK ABCB1 BCL2L1 STAT5A SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease UAP1 NPL RENBP HK1 CHIT1 NANP NAGK GNPDA1 AMDHD2 PGM3 SLC17A5 GNPNAT1 NANS GNE CMAS GFPT1 HEXA DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism KMO WARS1 INMT ALDH2 WARS2 ACMSD AANAT TDO2 AADAT KYNU AFMID CYP1A1 IDO1 DDC CAT HAAO TPH1 ASMT LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation TRAF6 IKBKG ME1 SLC25A1 SDHC LY96 SDHD SDHA TIRAP SDHB ACLY CS CD14 TLR4 MYD88 RELA CHUK MDH1 NFKB1 ACACA IKBKB NFKBIA HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis AVPR2 GNGT1 GNB1 PRKACB-1 FSHR ADCY2 GNAS-1 COAGULATION%SMPDB%SMP0000586 Coagulation F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation ALDH2 CYP2E1 ACSS1 ALDH1B1 ACSS2 ADH1C;ADH1B;ADH1A CAT MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency GPD1 GLYCTK PLPP1 AKR1B1 ALDH3A1 AGPAT1 GPD2 LIPC LPL GPAM PLPP2 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine GARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia HK1 G6PC1 GALE AKR1B1 GLB1 GAA LCT GLA B4GALT1 GALT UGP2 PGM1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) SC5D CYP51A1 DHCR24 MSMO1 HSD17B7 DHCR7 LBR NSDHL EBP TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) HGD TAT PAH FARSA YARS1 HPD FARSB FAH GSTZ1 IL4I1 GOT1-1 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway TUBB1 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC1 ABCC2 ABCB1 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) NMNAT2 SIRT1 NQO1 AIFM2 TP53 NADK CD38 NMNAT1 NAMPT NMNAT3 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer MPC1 IDH3B GOT2-1 DLAT IDH3A SLC1A4 SLC1A5 PDHA1 IDH3G IDH2 SLC7A7 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 SUCLG1 ACO2 DLD LDHA ME1 SLC16A1 ACLY SLC38A5 MYCBP-1 FH DLST PDHB DHTKD1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle FXYD2;FXYD6-FXYD2 CLCNKA;CLCNKB ATP1B2 ATP1A4 SLC12A6 ATP1B1 ATP1A3 SLC12A1 ATP1A2 ATP1B3-1 ATP1A1 REN FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway ATP4B ATP4A DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline EPRS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency PNMT DDC TH SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway PLCG1 GNAQ GNB1 MAP2K2;MAP2K1 MAPK1 CRK GNGT1 PXN RAF1 CXCR4 HRAS PIK3C2G MAPK3 GNAI1 PTK2 NFKB1 CXCL12 PTK2B NFKBIA BCAR1 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway ACE FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway AGTR1 ACE REN AGT DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway PCSK2 AOX1 CHRNA4 SLC6A2 CYP2C9;CYP2C19 ADRA1A SLC6A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A MAOB ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 MAOA ATP1B2 ATP1B1 CACNB1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway CYP1A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia PC MPC1 GPT AARS2 AGXT TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling MAP2K3 MAP4K2 CRADD IKBKG TRADD TRAF2 TANK TNF CASP2 RIPK1 MAP2K7 MAP2K6 MAP2K4 JUN MAP3K1 CHUK MAPK14 NFKB1 IKBKB NFKBIA MAPK8 ATF1 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation ALDH3A2 ABCD2 HACL1 PHYH-4 ABCD1 SLC27A2 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids ACADL SLC25A20 HADH CPT1A ECHS1 HADHB-1 ACAA2 ACSL1 HADHA CPT2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway PCSK2 AOX1 CHRNA4 CYP2A13;CYP2A6;CYP2A7-1 SLC6A2 ADRA1A SLC6A3 SLC6A4 CYP2B6 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A FMO3 ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CHRNA3 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 ALAS1 GUSB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 HDC AOC1 PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 CNDP1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine IARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle GOT2-1 MDH2 SLC25A12 SLC25A11 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 GDA DPYD ITPA CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway ALDH7A1 DMGDH SHMT2 SHMT1 SLC44A1 GNMT SLC44A2 MAT2B MTR-1 BHMT SARDH MAT2A CHDH PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C2 MBL2-1 MASP2 MASP1 LOC110384692;C4A;C4B_2;C4B C5 C6 C7 C9 C3-1 C8A FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis FASN ACACA CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway TYMP TYMS CES1 CDA SLC28A1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine RARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism UPB1 ALDH2 DPYD AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria PC MPC1 ME1 PDHA1 SLC25A11 MDH1 ACLY PDHB CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway P2RY12 ABCB1 CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway CACNB1 ABCC8 INS;INS-IGF2 SLC2A2 CACNA1A CACNA2D2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway ADRA1A CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) HSD17B10 ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 GDA DPYD ITPA CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells MAP2K3 RAC1 GRB2 PLCG1 LYN SYK SOS1 TNF MAP2K7 MAP2K6 BTK GAB2 PRKCA MAP2K2;MAP2K1 MAPK1 RAF1 HRAS CSF2 MAPK8 NRAS FCER1A FYN PDK1 FCER1G IL13 PLA2G4A IL4 IL3 IL5 LCP2 KRAS MAP2K4 MS4A2 VAV3 LAT PIK3R1 PIK3CA AKT1 INPP5D MAPK14 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC GLUD1;GLUD2 SUCLG2 ACO1 L2HGDH SUCLG1 ACO2 DLD FH DLST PDHB DHTKD1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway EGFR THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form HLCS ACACB BTD SPCS1 LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway ATP4B ATP4A NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia ASL ADSL ASNS ASRGL1 GAD1 CAD DDO DARS1 NARS1 ADSS1 ASPA IL4I1 ABAT ASS1 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism GGT6 CDO1 GAD1 CSAD ADO SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway PDE4D-1 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway EGFR THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway TPMT ADK RAC1 SLC28A2 SLC29A2 AOX1 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA ABCC4 ABCC5 SLC29A1 SLC28A3 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2RY12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation HOXB9 BTG1 CHAF1A PRMT1 TP53 FGF1 CCND1 NGF RB1 BTG2 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway CACNB1 ABCC8 INS;INS-IGF2 SLC2A2 CACNA1A CACNA2D2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium ADCY10 PRKG1 GUCY1A2 GUCY1B1 TRPC7 GUCY1A1 NOS3 TRPC3 TRPC4 TRPV4 KCNQ2 KCNQ3 PRKG2 KCNQ4 KCNQ5 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway SLC22A3 ABCG2 CHPT1 PCYT2 CMPK1 PGK1 ABCC1 ABCC2 SLC22A1 ABCB1 ABCC4 DCK NME1 NT5C SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SLC22A2 PCYT1A ABCC3 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway ABCB1 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 SLC6A2 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) UGDH GALE UXS1 GALK1 GALT GCK UGP2 PGM1 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 CYP2C9;CYP2C19 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 PTGS1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 TOP2A MPO ABCB1 PTGS2-2 TOP2B ABCC3 PDIA2 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway ATP4B ATP4A SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification SLC2A1 PNP-1 AS3MT GSTO1 AQP9 LOC100509620;LOC112267859;AQP7 SLC2A4 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) HGD TAT PAH FARSA YARS1 HPD FARSB FAH GSTZ1 IL4I1 GOT1-1 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine SARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling GNG2 ROCK1 GNB1 ITPR1 AKT1 LPAR2 PLCB1 ADCY1 SRF BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway KLB FGF19 NR1H4 SLC10A2 FGFR4 FGFR3 FGFR2 FGFR1 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell SNTA1 CACNB1 ABCC8 SNTB1 SNTB2 SLC2A2 CACNA1A CACNA2D2 GCG SCN5A FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria TPI1 HK1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids SLC25A20 CROT PEX11G CRAT PEX13 PEX14 ABCD2 ACSL1 ABCD1 CPT2 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin PTGIR MYL3 MYLK GNGT1 GNB1 PRKACB-1 ADCY2 GNAS-1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 TRAF6 IKBKG ECSIT RELA IRAK1 TLR1 TOLLIP TLR9 TAB3 TLR8 TLR7 TAB2 TLR6 TAB1 MAPK8 TLR5 TLR3 TLR2 MAP3K7 MAP2K4 LY96 TIRAP CD14 TLR4 MYD88 MAP3K1 CHUK MAPK14 NFKB1 IKBKB NFKBIA GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway UGT1A1;UGT1A6 PDIA6 ABCG2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 BCHE ABCC1 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 TOP1 ABCB1 CES2 CES1 PDIA2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis VNN1 PPCS PANK1 COASY PPCDC ENPP1 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway ACE REN AGT 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine RPS6KA1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS MAPK8 PAK1 ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 MAPK11 JUN ADORA2A RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA GNGT1 MAP3K1 PRKACB-1 AKT1 CHUK CREB1 ELK1 GNAS-1 NFKB1 IKBKB PDPK1 NFKBIA ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor PRKCA GNAQ ITPR1 PLCB1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary MTHFD1 MTHFD2 FPGS GGH FTCD MTHFR DHFR2;DHFR ST20-MTHFS;MTHFS SLC46A1 MTFMT ALDH1L1 MTHFD1L SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria HSD17B10 ECHS1 HADHB-1 ACAA2 MECR PPT1 HADHA ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 TARS1 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism UGDH GALE UXS1 GALK1 GALT GCK UGP2 PGM1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway CDKN1A TUBB1 ABCC10 TP53 ABCC1 ABCC2 ABCB1 RALBP1-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ABCC3 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway ACE CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway ADRA1A CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway ACE REN AGT BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis COQ3 COQ2 COQ7 COQ6 COQ5 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G SDHC SDHD SDHA SDHB CS PC SUCLG2 SUCLG1 ACO2 DLD FH MDH1 DLST PDHB DHTKD1 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia HAL ALDH2 FTCD ALDH3A1 HARS1 CARNMT1 HDC AOC1 PRMT3 HNMT HARS2 MAOA CNDP2 UROC1 AMDHD1 CARNS1 CNDP1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway PDE4D-1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids ACADM SLC25A20 HADH ECHS1 HADHB-1 ACAA2 HADHA ACSM1 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism PAPSS2 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 SULT2B1 CHST11 BPNT1 SUOX ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism UGT1A1;UGT1A6 PDIA6 CYP11B1;CYP11B2 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 SRD5A1 HSD17B3 AKR1D1 CYP19A1 HSD11B1 PDIA2 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 GSTM1;GSTM2-1 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate MPC1 IDH3B DLAT IDH3A EGLN1 EGLN3 EGLN2 PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB CS PC SUCLG2 ACO1 SUCLG1 SLC25A10 ACO2 DLD FH DLST PDHB DHTKD1 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway FLT1 VEGFA KDR NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 OPRM1 PPIB SDF2L1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 HSPA5 HYOU1 PDIA2 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis PCYT2 PISD PTDSS1 CEPT1 CHKA METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 YARS1 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism MINPP1 IMPA1 PIK3C3 ITPKA INPP5J PLCD3 VAC14 BECN1 PTPMT1 PIK3R4 AMBRA1 PIK3CA FIG4 IPPK PIKFYVE MIOX ISYNA1 INPP1 ITPK1 IPMK PI4KA INPP4A PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway EHHADH-1 HSD17B10 HADHB-1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ACADSB HADHA CYP2B6 ACSM1 IVD PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid DARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1A4 ATP1B1 ATP1A3 ATP1A2 ATP1B3-1 ATP1A1 LCT SLC2A2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway ACE REN AGT METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway SNTA1 SNTB1 SNTB2 SCN5A LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 VKORC1 FGB FGA F10 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway ABCC10 CYP2D6;LOC107987479;LOC107987478-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway PRKCA ADAM17 EGFR ERBB3 ERBB4 NRG2 PSEN1 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway CDKN1A PCNA RAC1 CCND1 CAP1 VAV3 PDGFRA WASF1-1 LIMK1 CCND3 CDK5 PLD1 ACTB-1 MYLK RPS6KB1 MYL2 CFL1 ARFIP2 PPP1R12B MAP3K1 RALBP1-1 PAK1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism DAO TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation CBS;CBSL CTH KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis GPI PGAM1 PGAM2 BPGM ENO1 HK2 GAPDH-1 ALDOA GALM-2 PGK1 G6PC1 PFKM PKLR SLC2A2 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway TRAF6 IKBKG TRADD TNF RIPK1 RELA IRAK1 CAMKK2 IL1R1 NCOA3 TNFRSF1B TNFRSF1A IL1A MAP3K14 TAB1 CAMKK1 UBB;UBC FADD MAP3K7 TLR4 MYD88 MAP3K1 CHUK NFKB1 IKBKB NFKBIA METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism ACTB-1 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway PCSK2 CHRNA4 SLC6A2 CYP2C9;CYP2C19 ADRA1A SLC6A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 CYP2B6 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway CCKBR HRH2 SST GAST CLIC2 SSTR4 ATP4B ATP4A CHRM3 CA1 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism FADS1 JMJD7-PLA2G4B;PLA2G4B FADS2 ELOVL4 ELOVL5 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism FECH COX15 UROS CPOX PPOX ALAD FTMT UROD HMBS HMOX1 FLVCR2 BLVRA COX10 ALAS1 GUSB UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2B1 STS SRD5A1 HSD17B1 HSD17B3 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism PEMT AHCY MAT2B MTR-1 BHMT ALDH7A1 MAT2A CHDH BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency HLCS ACACB BTD SPCS1 FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway ACE REN AGT ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A CARS1 RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL GRB2 TP53 JAK2 SOS1 CDKN1B BAD MDM2-2 GAB2 CBL MTOR CRKL RPS6KB1 MYC PIK3R1 SKP2 CRK BCL2L1 STAT5A PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency PC MPC1 GPT AARS2 AGXT CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway EGFR FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway IMPDH2 ABCG2 SLCO1B3;SLCO1B3-SLCO1B7;SLCO1B7;SLCO1B1 ABCC2 ABCB1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CES2 CES1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 IMPDH1 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP2A13;CYP2A6;CYP2A7-1 HYOU1 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 RETSAT RDH8 RDH12 AWAT1 RDH11 LRAT ADH1C;ADH1B;ADH1A BCO1 DGAT1 DHRS3 RPE65 DHRS4 CYP26A1 DHRS9 ALDH1A2 PNPLA4 PDIA2 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency ALDH3A1 PNMT GOT1-1 DDC AOC1 ADH1C;ADH1B;ADH1A HGD MAOA HAAO MIF DBH TYR COMT FAH GSTZ1 DCT CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway P2RY12 ABCB1 CYP1A2 CYP2C9;CYP2C19 PON1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine RPS6KA1 GNB1 MAP2K7 MAP2K6 BAD MAP2K2;MAP2K1 MAPK1 HRAS ADCY2 MAPK8 PAK1 ADORA2B ATF2 PRKCZ PARD6A RAP1A MAP3K4 BRAF NFKB2 MAPK11 JUN RAPGEF2 ARHGEF7 RAPGEF3 CDC42 PIK3CA GNGT1 MAP3K1 PRKACB-1 AKT1 CHUK CREB1 ELK1 GNAS-1 NFKB1 IKBKB PDPK1 NFKBIA FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome GPI PGAM1 PGAM2 BPGM ENO1 HK2 GAPDH-1 ALDOA GALM-2 PGK1 G6PC1 PFKM PKLR SLC2A2 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell SST CACNB1 ABCC8 SLC2A2 CACNA1A CACNA2D2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling TSC2 TSC1 RHEB EIF4EBP1 EIF4E SLC7A5 MTOR RPS6KB1 AKT1 PIK3CG PIK3R6 INS;INS-IGF2 IRS1 INSR IRS2 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency GCHFR QDPR GCH1 SPR AKR1B1 DHFR2;DHFR PTS CBR1-1 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency HMGCL BDH1 ACAT1 OXCT1-1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling TLR4 P4HA3 IL1B NLRP3 HIF1A SIRT3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway ACE NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 OPRK1 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin GNGT1 GNB1 PRKACB-1 CREB1 GNAS-1 PPP1CA HTR4 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 CYP1A1 HYOU1 HSD17B1 COMT PDIA2 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway EGFR NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway MAP2K3 GRB2 PRKCB SOS1 ITPR1 PLCB1 MAP2K7 PRKCA CACNA1D CACNA1F JMJD7-PLA2G4B;PLA2G4B MAP2K2;MAP2K1 MAPK1 CACNA1S RAF1 HRAS CACNA1C PRKACA-1 MAPK8 JUN CALML6 CACNA2D2 SRC LHB CAMK2A PLD1 GNA11 CDC42 GNRHR CACNB1 MAP3K2 EGR1 EGFR MAP3K1 MMP2 FSHB ACTN4 ADCY1 MMP14 CGA LRRC7 ELK1 MAPK14 GNAS-1 GNRH1 HBEGF ATF4 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway TYMS INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) ACADM GCDH ACADVL CPT1A HADHB-1 ACAA2 ACSL1 ACADSB HADHA CPT2 ACADL ACADS ECHS1 ACAT1 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 MAP2K3 TRAF6 IKBKG MAP2K6 ECSIT RELA IRAK1 TOLLIP TLR9 TLR7 TAB2 TAB1 MAPK8 TLR3 TLR2 MAP3K7 MAP2K4 LY96 JUN TIRAP CD14 TLR4 MYD88 MAP3K1 CHUK FOS ELK1 MAPK14 NFKB1 IKBKB EIF2AK2 NFKBIA PPARA CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis PTPMT1 GPD1 AGPAT5-1 CRLS1 CDS2 PGS1 GPAM T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway CD3G PPP3CB CD3E PPP3CC CD3D RAC1 GRB2 RASGRP1 PLCG1 PRKCB ZAP70 NFATC3 LCK SOS1 NFATC2 PTPN7 SHC1-1 NFATC1 CD247 CALM3;CALM1 NFATC4 PRKCA RELA MAP2K2;MAP2K1 RAF1 HRAS PIK3CG MAPK3 VAV1 MAPK8 FYN UBB;UBC MAP2K4 LAT JUN PIK3R1 PIK3CA MAP3K1 FOS ELK1 NFKB1 PPP3CA NFKBIA MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway TPMT ADK PPAT RAC1 SLC28A2 SLC29A2 HPRT1 AOX1 IMPDH1 GMPS ABCC4 ABCC5 SLC29A1 SLC28A3 XDH FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway CACNB1 CACNA1C CACNA2D2 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway PRKCA PLCG1 PRKCB P2RY2 PTK2B MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type MSRB2 MSRB3 DNMT1 SHMT1 AMD1 MARS1 MTHFR MAT2B SRM IL4I1 BHMT MTAP CBS;CBSL MAT2A CHDH CTH MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) CDA DUT DPYS NME6 CAD CANT1 AK3 UPB1 TYMP RRM2-1 DHODH UCKL1 GDA DPYD ITPA CTPS1 CMPK2 TYMS TK1 DCTD NT5C2 RRM2B NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway PRKCA ALDH2 NOS1 GRIN1 PRKACB-1 ITPR1 CALM3;CALM1 GRIN3A DLG4 PPP3CA GRIN2A XDH METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia PDXK PNPO PDXP ALPL AOX1 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency PPAT GOT2-1 GPT CPS1 NAGK GLUL GNPNAT1 GSS GAD1 CAD GSR GLS2 GCLC ALDH5A1 GLUD1;GLUD2 QARS1 GCLM EARS2 GMPS ABAT GFPT1 ALDH4A1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome PIP4K2A PIK3C3 CDIPT PLCB1 VAC14 BECN1 PTEN PIK3R4 PIK3CD AMBRA1 PIK3R1 PIK3C2A EGFR FIG4 INPP4B PIKFYVE SYNJ1 INPP5D ERBB2 INPP5E PI4KA PIP5K1A ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway PCSK2 CHRNA4 SLC6A2 CYP2C9;CYP2C19 ADRA1A SLC6A3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 CYP2D6;LOC107987479;LOC107987478-1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic LDHA GCLM MPST CTNS CDO1 CARS1 GOT1-1 GCLC CTH BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) ABCC4 SLCO1A2 NR1H4 SLC10A2 GPBAR1 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids ALDH2 SLC25A20 CRAT PEX13 PEX14 ABCD2 ACSL1 HACL1 PHYH-4 ABCD1 CPT2 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 VKORC1 FGB FGA F10 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome CMPK1 SLC2A1 NME2 LALBA G6PC1 SLC35A2 B4GALT1 GALT UGP2 CANT1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway TYMS DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway PCSK2 CHRNA4 SLC6A2 ADRA1A SLC6A3 SLC6A4 GRIN2A DRD1 SCN1B ATP1A4 CHRNB2 KCND2 ATP1A3 HTR1A OPRM1 ATP1A2 GRIN1 POMC SCN10A ATP1A1 GRIN3A CACNA1A ATP1B3-1 KCNIP2 CACNA2D2 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway UGT1A1;UGT1A6 PDIA6 PDIA4 DNAJB11 ERP29 PPIB SDF2L1 HSPA5 HYOU1 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 PDIA2 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 GRHPR LDHA ALDH2 DLAT LDHD ME1 HAGH PCK1 PDHA1 AKR1B1 PC DLD ACSS2 PKLR MDH1 ACACA GLO1 ACAT1 ACOT12 PDHB ACYP1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I HIBADH HMGCL AUH AOX1 HMGCS2 MCCC2 ACAD8 MCCC1 OXCT1-1 IVD BCAT1 DLD BCKDHA HSD17B10 ECHS1 BCKDHB ABAT ACAT1 ALDH6A1 PCCA PCCB ALDH2 DBT ACADM HIBCH ACAA2 ACADSB ACADS SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism PLPP1 ARSA GAL3ST1 CERK GLB1 SGMS1 SPHK2 GBA GLA SGPP2 GALC UGCG UGT8 ACER1 NEU3 SGPL1 SPTLC1 ACER3 DEGS2 KDSR B4GALT6 ENPP7 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) HSD3B1;HSD3B2 AKR1D1 CYP11B1;CYP11B2 CYP11A1 CYP21A2 CYP17A1 HSD11B1 HSD11B2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency GATM ALDH2 SDS GLDC AMT DMGDH MAOA ALAS1 SHMT2 SHMT1 GLYCTK GCAT GNMT DLD GARS1 GAMT SARS1 SRR PSAT1 SARDH PHGDH AGXT PSPH CTH GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production GNGT1 GNB1 PRKACB-1 POMC MC2R GNAS-1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway ALDH3A1 CYP2A13;CYP2A6;CYP2A7-1 CYP2C9;CYP2C19 ALDH1A1 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CYP2B6 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway ATP4B ATP4A NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway HSP90AA1 ARNT AHR EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling GNG2 ROCK1 GNB1 AKT1 ADCY1 GNAS-1 SRF LPAR6 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation TPI1 HK1 AKR1B1 ALDOB PFKL ALDOA FBP1 PFKFB1 PMM1 MPI SORD KHK GMPPB GMDS FCSK FPGT PHPT1 GFUS GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) GATM DAO EPRS1 P4HA3 CPS1 ASL CKB NOS1 OTC PRODH;LOC102724788 GOT1-1 GLUD1;GLUD2 GAMT RARS2 OAT ARG1 PYCR2 ASS1 ALDH4A1 SLC25A15 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis HSD3B7 AKR1D1 HSD17B4 CYP7B1 BAAT CYP46A1 CYP8B1 CYP7A1 CYP39A1 LIPA CYP27A1 CH25H AMACR ACOX2 SCP2 SLC27A5 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 CYP1A2 CYP2C9;CYP2C19 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine HARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency GPI G6PD TALDO1 PGD DERA RPIA PFKL RPE;RPEL1 PGLS ALDOA TKT FBP1 PGM1 RBKS DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway CYP2D6;LOC107987479;LOC107987478-1 SLC6A2 SLC6A4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway NR3C2 CLCNKA;CLCNKB SLC12A6 SLC38A4 SLC12A3 SLC14A2 SLC12A1 SCNN1G SLC7A5 SLC7A6 SLC7A7 SLC7A8 SCNN1D SLC7A9 SCNN1B SCNN1A ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP1B3-1 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 SLC22A6 SLC22A2 SLC1A1 SLC3A1 SLC3A2 SLC6A20 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin LHB GNGT1 GNB1 PRKACB-1 CREB1 ADCY2 CGA GNAS-1 PPP1CA LHCGR LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation FXYD2;FXYD6-FXYD2 ATP1B2 SLC5A1-1 ATP1A4 ATP1B1 ATP1A3 ATP1A2 ATP1B3-1 ATP1A1 LCT SLC2A2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency MPC1 TPI1 LDHA PANK1 GPI MDH2 PGAM1 PGAM2 BPGM PCK1 ENO1 HK2 GAPDH-1 SLC37A4 SLC25A11 ALDOA GALM-2 FBP1 PGM1 PC G6PC1 SLC2A2 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism GPD1 GLYCTK PLPP1 AKR1B1 ALDH3A1 AGPAT1 GPD2 LIPC LPL GPAM PLPP2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency GPI HK2 MGAM GBE1 PYGL GCK PGM2L1 UGP2 GYS2 PGM1 UGDH SI AMY1A;AMY1C;AMY1B;AMY2A;AMY2B GUSB AGL-1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis DGAT1 LPIN1 GPD1 AGPAT1 GPAM SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency CBS;CBSL CTH HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway ATP4B ATP4A VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway AGTR1 GNG2 GNAQ GNB1 ACE REN AGT CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia UPB1 ALDH2 DPYD AOC3 CNDP1 ABAT DPYS GAD1 ALDH6A1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation ALDH8A1 ACMSD DLD DLST DHTKD1 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 WARS1 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism MINPP1 IMPA1 ITPKA INPP5J NUDT3 PPIP5K1 IP6K1 INPP4B IPPK ISYNA1 INPP1 ITPK1 IPMK INPP4A ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway F12 F11 FGG F13A1 PLAT PLG F2 F3 F5 COL1A1 F7 F8 F9 GGCX F13B KLKB1 SERPINC1 VKORC1 FGB FGA F10 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II SLC25A2 GCDH AADAT PIPOX SLC7A2 ALDH7A1 AASS DLD HADH ECHS1 DLST ACAT1 DHTKD1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action HRH1 GNG2 PRKCB GNAQ GNB1 ITPR1 PLCB1 NFKB1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria PCCA PCCB DBT ACADM MLYCD ACSS1 HIBCH LDHAL6B DLD BCKDHA ACSS3 ECHS1 BCKDHB ABAT ACACA ACAT1 ALDH6A1 MCEE AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency HSD3B1;HSD3B2 AKR1D1 CYP19A1 CYP17A1 UGT2B11;UGT2B10;UGT2B28;UGT2B4;UGT2B7;UGT2B15;UGT2B17-1 SULT2B1 STS SRD5A1 HSD17B1 HSD17B3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule CLCNKA;CLCNKB SLC12A3 ATP1B3-1 AQP2 AQP3 ATP4B REN ATP4A FXYD2;FXYD6-FXYD2 ATP1B2 ATP1A4 ATP1B1 ATP1A3 TRPV5 ATP1A2 ATP1A1 SLC8A1 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria GOT2-1 GPT SLC1A4 CPS1 ASL SLC1A5 SLC25A12 OTC GLS2 GLUD1;GLUD2 ARG1 ASS1 SLC25A15 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway ACE PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway CHRM2 HCN4 RYR2 KCNE2 ATP1A4 KCNE1;KCNE1B ATP1A3 ATP2A2 ATP1A2 KCNA5 ADRB1 ATP1A1 CACNA1C CACNA1H SLC8A1 CACNA1G PRKACA-1 SCN5A KCNJ2 SNTA1 KCNJ3 KCNH2 KCNJ4 KCNJ5 KCNJ8 KCNJ11 ATP1B3-1 ABCC8 KCNIP2 KCND3 TPM2 TPM1 CACNA2D2 ABCC9 FXYD2;FXYD6-FXYD2 ATP1B2 ATP1B1 CACNB1 DLG1 PRKAR1A KCNQ1 KCNK1 ALG10;ALG10B SNTB1 SNTB2 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation IKBKG PLCB1 MAPK11 PTGS1 PRKCA MAPK1 SUCNR1 CHUK NOS3 CREB1 MAPK3 NFKB1 IKBKB TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway CYP2D6;LOC107987479;LOC107987478-1 SULT1A2;SULT1A1;SULT1A4;SULT1A3-1 FMO1 FMO3 CYP3A4;CYP3A7-CYP3A51P;CYP3A7-2 ESR1 CYP2B6 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 GUCY1B1 GDA AK1 GMPS GMPR NUDT2 ADCY2 TXN NT5C2 NUDT5 PFAS DGUOK ATIC XDH GUK1 PPAT ATAD1 GUCY1A2 RRM1 ADSL PDE4D-1 ENTPD5 AMPD1 HPRT1 ENTPD8 PAICS APRT PDE10A NME6 IMPDH1 ADSS2 GART RRM2-1 PNP-1 ADA ITPA D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway CASP8 CASP10 CASP3 ARHGDIB CYCS-1 JUN APAF1 PARP1 GZMH;GZMB-1 CASP9 PRF1 ARHGAP5 ARHGAP32 CASP1 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria CASP7 GGCT GCLM GGT6 GPX1 GSTO2 ANPEP OPLAH GSS GSR GCLC ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway GPX1 PTGIS CYP2J2-1 EPHX2 ALOX15 ALOX12 ALOX12B CYP4F3;CYP4F2;CYP4F12;CYP4F11 CBR1-1 LTC4S ALOX15B PTGS1 CYP2B6 CYP2U1 ALOX5 PRXL2B TBXAS1 JMJD7-PLA2G4B;PLA2G4B LTA4H CYP2E1 PTGDS GGT1 PTGES PTGS2-2 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine NARS1 RPL4 RPL30 RPLP1-2 RPL3 RPL32 RPL31 RPL34 RPLP0 RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RACK1 RPL37A-1 RPLP2 RPL35 RPL38 RPS11 RPL36-1 RPL39 RPS10 RPS13 RPL15-1 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPL22 RPS6 RPS3A RPSA RPL13A-1 RPL24 RPL27 RPL26 RPL29 UBA52 RPL28 RPL10;RPL10L-1 RPL11 RPS15A RPS3 RPL14 RPL13 RPL12-1 RPS2 RPL18 RPL17 RPL19 RPL35A RPL23A RPS25 RPS27 RPL5-1 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine HRH2 GNGT1 GNB1 PRKACB-1 CREB1 ADCY2 GNAS-1 PPP1CA DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis SC5D MVD FDFT1 FDPS IDI1 MVK GGPS1 CYP51A1 DHCR24 MSMO1 HMGCR HSD17B7 LSS LIPA ACAT2 TM7SF2 SQLE NSDHL EBP SOAT1 PMVK LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling GNG2 GNB1 ITPR1 AKT1 PLCB1 ADCY1 LPAR3 GNAS-1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate MPC1 IDH3B DLAT IDH3A PDHA1 IDH3G IDH1 IDH2 SDHC SDHD SDHA SDHB GLS2 CS PC SUCLG2 ACO1 SUCLG1 ACO2 DLD FH DLST PDHB DHTKD1 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine)