S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Enoph1 Adi1 Kyat1 Mri1 Apip L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III Mpst Got1 Cisd1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) Gad1 Gad2 ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II Cyp2a3 Cyp19a1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) Fads2 Elovl5 Hsd17b12 Ehhadh METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI Ldhd GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation Gcdh Echs1 Acat1 Acat2 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis Asns PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation Pecr Aldh3a2 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II Ubiad1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Synj2 Inppl1 Inpp5d Itpka Inpp5f Synj1 Inpp5a Itpkc Itpkb Ipmk Bpnt2 Impa2 Ocrl Pten Impa1 Inpp5k Inpp1 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) Cbs Cth SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis Dhodh Rrm2 Tyms Rrm2b Cad Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 Dtymk Umps Nme7 Nme6 Ctps2 Ntpcr Ctps1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis Gphn SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 Asmt ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis Tm7sf2 Hsd17b7 Nsdhl Lbr &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis Acsl1 Acsm3 Acsbg1 Acsm4 Fads2 Slc27a2 Acsm5 Acsbg2 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II Rnmt Cmtr2 Cmtr1 Rngtt PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis Alox15 Ltc4s Gstm4 Gpx4 Alox12 Alox5 Dpep1 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Fdps Idi1 Hmgcs1 Pmvk Ggps1 Hmgcr Mvd Hmgcs2 Acat1 Acat2 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation Gls2 Gls L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation Hgd Tat Fah Hpd NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation Adh4 Maoa Maob Comt Tomt Aldh2 Adh6 Aldh3a2 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II Nagk Amdhd2 Gnpda2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation Hal Uroc1 Mthfd1 Ftcd NADH REPAIR%BIOCYC%PWY-6938 NADH repair Naxe URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) Dpys Dpyd Upb1 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds Synj2 Pip5k1b Inppl1 Plcb4 Plcb3 Pikfyve Ip6k1 Pik3c3 Ip6k2 Plcb2 Plcb1 Ip6k3 Sacm1l Pi4k2a Ippk Plcg1 Plcg2 Mtmr14 Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pip4k2c Pik3r2 Pik3r3 Pik3r4 Pip4k2a Pi4kb Plch2 Plcd1 Plcd4 Plcd3 Itpk1 Cdipt Inpp5d Pik3cg Itpka Pik3cb Pik3cd Pip4p2 Synj1 Inpp5a Pip4p1 Itpkc Pi4k2b Itpkb Plcz1 Ipmk Pik3c2b Plce1 Pik3c2a Ocrl Pik3c2g Pten Fig4 Mtmr3 Inpp5k Ppip5k1 Pip5k1c L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation Prodh METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I Glo1 Hagh L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation Gpt2 Gpt ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss2 Acss3 Acss1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Smox Sat2 Sat1 Paox L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis Pah ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing Aloxe3 Slc27a4 Cyp4f39 Alox12b Cers3 Tgm1 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis Umps Dhodh Cad GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation Pnp Gda Xdh SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation Cat Sod3 Sod2 Sod1 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis Impa2 Isyna1 Impa1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) Ndufab1 Ndufc1 Ndufc2 Sdhd Sdhc Sdhb Sdha Ndufa12 Ndufa11 Cox6a1 Cox7b Uqcrfs1 Ndufs1 Ndufs3 Ndufs2 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs6 Mt-co3 Mt-co2 Ndufs8 Uqcrq Ndufa1 Ndufa3 Ndufa2 Ndufa5 Ndufa4 Ndufa7 Ndufa6 Ndufa8 Ndufb11 Ndufb10 Cox7a2 Cox5a Cox5b Mt-co1 Cyc1 Mt-nd5 Mt-nd4 Ndufb2 Mt-nd6 Mt-nd1 Uqcrc2 Ndufb3 Mt-nd3 Uqcrc1 Ndufb6 Mt-nd2 Mt-nd4l Ndufb5 Ndufb8 Ndufb7 Ndufb9 Cox8a Ndufv2 Ndufv1 Ndufv3 Uqcr11 Ndufa10l1 Mt-cyb DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Dhdds Nus1 Srd5a3 Dolk Dhrsx PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis Adsl Impdh2 Impdh1 Ak3 Gmps Rrm2 Ak2 Ak4 Rrm2b Adss2 Ak7 Nme3 Pfas Nme2 Ak8 Nme4 Atic Nme1 Ppat Guk1 Gart Paics Nme7 Nme6 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) Nmnat1 Nmrk1 Nmnat2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt Gad1 Gad2 Glud1 Aldh5a1 Abat PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pd Pgls UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) Ubiad1 Coq5 Coq6 Coq7 Pdss2 Coq2 Coq3 Coq4 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis Impdh2 Nme7 Nme6 Impdh1 Gmps Rrm2 Rrm2b Nme3 Nme2 Nme4 Nme1 Guk1 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis Shmt2 Psat1 Shmt1 Phgdh Psph Vps29 PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage Nme7 Nme6 Dguok Dck Nme3 Nme2 Nme4 Nme1 Guk1 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) Sult1a1 Dio1 Dio2 Ugt1a9 Ugt2b34l1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation Gls2 Gls Asns VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle Nqo1 Ggcx Vkorc1l1 Vkorc1 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I Por Cyp4x1 Cyp2u1 Cyp2a3 Cyp2s1 Cyp1b1 Cyp1a2 Sult1a1 Ugt2b34l1 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation Pnp Ada GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I Nat8 Gstm2 Gsto2 Mgst3 Gstp1 Gstt2 Mgst2 Mgst1 Gstt1 Gsta6 Gsta3 Gsta1 Gsta2 Anpep Gstm7 Gstm5 Gstk1 Gstm1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Mthfd1 Gart ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis Lta4h Ptgs2 Alox5 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I Agmat PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Chkb Selenoi Pcyt2 Cept1 Etnk2 Etnk1 CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Sqle Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Tm7sf2 Hsd17b7 Nsdhl Lbr PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation Nme7 Nme6 Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 Dtymk PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis Alox15 Gpx4 Alox12 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) Dhtkd1 Aadat Pycr1 Pipox CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal1 Hyal5 Hyal4 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis Tyr ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis Atp6v0b Atp5f1d Atp5f1c Atp5pb Atp6v1e1 Atpaf1 Atp6v0a1 Atp6v1c1 Atp5pf Atpaf2 Atp5po Atp6v0c Atp6v1a Mt-atp6 Atp5mc1 Atp6v1b2 Vps9d1 Atp6v0d1 Atp5mc3 Atp5mc2 Atp5mf Atp5me Atp6v0e1 Atp5mg Atp6v1g1 Atp5f1b Atp5f1a Atp6v1f Atp6v1d Atp6v1h FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation Mthfd1l Shmt2 Shmt1 Mthfd1 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis Psat1 Phgdh Psph Vps29 L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I Aspg Asrgl1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I Acod1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis Pfas Ppat Gart PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I Cda Uck1 Uck2 Uckl1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis Acat1 Acat2 Fdps Sqle Idi1 Ebp Dhcr24 Hmgcs1 Pmvk Sc5d Kcnh7 Ggps1 Dhcr7 Hmgcr Fdft1 Mvd Lss Hmgcs2 Tm7sf2 Hsd17b7 Nsdhl Lbr PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III Arg2 Odc1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation Cda Upp1 Upp2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Hmgcs2 Acat1 Hmgcl Bdh2 Bdh1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation Akr1a1 Cryl1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pip5k1b Pip4k2b Pip4k2c Pip4k2a Pi4kb Plch2 Plcd1 Plcd4 Plcd3 Cdipt Plcb4 Plcb3 Pi4k2b Plcz1 Plcb2 Plce1 Plcb1 Pi4k2a Plcg1 Plcg2 Pip5k1c ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV Aldh2 Acss2 Acss3 Cat Acss1 Aldh3a2 CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) Cyp2e1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation Hsd17b10 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Acadsb Echs1 Acat1 Acat2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis Agxt2 Agxt ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) Fads2 Elovl7 Fads1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis St3gal5 St3gal2 B3galt1 B3gnt5 B3gnt2 Fut2 A4galt B4galt1 Fut1 B4galt2 B4galt3 B4galt4 B3galnt1 B4galt6 St6gal1 B4galnt1 B3galt5 B3galt4 St8sia2 St8sia3 Ugcg St8sia1 St3gal6 St3gal4 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I Hmox1 Hmox2 Blvra Ugt1a5 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B3gnt5 B3gnt2 B4galt1 B4galt2 B4galt3 B4galt4 B4galt6 St6gal1 St8sia2 St8sia3 Ugcg St3gal6 St3gal4 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fcsk Fpgt GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Gmds THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III Tpk1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation Dpys Dpyd Upb1 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation Nnt CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation Aldh7a1 Chdh ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI Adk PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis Gnpat Pcyt1b Pcyt1a Far2 Far1 Chka Peds1 Agpat1 Pcyt2 Cept1 Etnk2 Etnk1 Chkb Selenoi L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis Tyr L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) Kmo Ido2 Acmsd Ido1 Dhtkd1 Kyat1 Tdo2 Aadat Haao Kynu Got2 Aldh8a1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) Cyp2a3 Cyp19a1 Hsd17b11 Hsd17b3 Hsd17b1 Hsd17b7 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) Acsl1 Acsm3 Acsm4 Fads2 Elovl5 Acsm5 Elovl7 Fads1 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation Suox HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis Hdc GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis St3gal5 St3gal2 B3galt4 Ugcg St8sia1 B4galt6 St6gal1 B4galnt1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3galt5 B3galt1 Fut2 Abo2 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III Cyp2e1 Akr1b10 Akr1b1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat2a Mat1a PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation Enpp2 Tmem86b SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis Dhodh Cad Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 Umps Nme7 Nme6 Ctps2 Ctps1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ipmk Ippk Itpk1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis Shmt2 Shmt1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis Fads6 Scd Acot2 Acot3 Acot4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis Tbxas1 Cbr1 Hpgds Hpgd Ptges Ptgds Ptgs2 Ptgis Ptges2 Akr1c3 Ptgs1 Ptgr2 Ptgr1 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation Mtmr14 Synj2 Inppl1 Inpp5d Inpp4a Inpp4b Inpp5f Pip4p2 Synj1 Pip4p1 Ocrl Sacm1l Pten Mtmr3 Inpp5k ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis Elovl4 Tecr Hsd17b12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) Ppcdc Coasy RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis Alox15 Ephx3 Gpx4 Alox12 Alox5 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) Cyp4x1 Cyp2e1 Cyp2u1 Cyp2a3 Cyp2s1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis Tbxas1 Hpgds Hpgd Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 Ephx3 Dpep2 Cyp4f18 Cyp2j4 Cyp4f4 Cyp2d4 Alox15b Lta4h Ptgs2 Gstm4 Gpx4 Alox12 Alox5 Dpep1 Alox15 Ltc4s PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination Padi3 Padi4 Padi1 Padi6 Padi2 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) Pah PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II Ptdss2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Synj2 Inpp5d Inppl1 Itpka Synj1 Inpp5a Itpkc Itpkb Ipmk Ocrl Pten Inpp5k INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis Ip6k1 Ip6k2 Ipmk Ip6k3 Ippk Ppip5k1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism Dio3 Dio1 Dio2 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway Txnrd2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis Ptgs2 Alox5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate Acly KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Oxct1 Acat1 Bdh2 Bdh1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation Aldh1b1 Aldh3b1 Aldh3a1 Pgm2 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation Alox15 Alox12 Alox5 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine Bhmt Bhmt2 Mtr SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation Por Cyp4x1 Maoa Cyp2u1 Cyp2a3 Cyp2s1 Cyp1b1 Cyp1a2 Sult1a1 Ugt2b34l1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Acmsd Dhtkd1 Aldh8a1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions Gpx3 Gsr Gpx7 Gpx4 Gpx2 Gpx1 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage Nmnat1 Nmnat2 Nampt HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation Aoc1 Hnmt CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis Agpat3 Lclat1 Agpat4 Cds2 Agpat2 Agpat1 Cds1 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Gpam Abhd5 Mboat2 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Bpgm FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III Fa2h Hacl1 Aldh3a2 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis Bpgm Gpi Mdh1 Mdh2 Eno1 Gapdhs Aldob Aldoc Eno3 G6pc1 Eno2 Aldoa G6pc3 Pc Pgk1 Pgam2 Tpi1l2 Pgk2 Fbp1 Pck1 Fbp2 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I Maoa Maob Aldh2 Aoc3 Aldh3a2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Rpia Rpe Taldo1 Tkt VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II Elovl1 Tecr Hsd17b12 Elovl7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) Acsl1 Acsm3 Acsbg1 Acsm4 Fads2 Slc27a2 Elovl5 Acsm5 Hsd17b12 Acsbg2 Elovl7 Fads1 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle Ggct Gclc Gss Cndp2 Gclm Oplah UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I Ctps2 Ntpcr Ctps1 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis Hk3 Pygb Pygl Pgm2 Pygm Gck Pgm1 Hk2 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation Aldh6a1 Bckdhb Bckdha Dbt Abat Bcat1 Dld Bcat2 Echs1 Hibch Hibadh ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) Ate1 Naa20 Naa25 Ntaq1 Metap1 Apeh Metap2 Ntan1 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis Ptgs2 Alox5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis Got1l1 Got1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II Hk3 Pgm2 Gck Pgm1 Hk2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II Maoa TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II Rtraf Fam98b Tsen2 C9h2orf49 Tsen34 Rtcb Tsen15 Ddx1 Tsen54 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage Cda Tk2 Tyms Dck PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis Nme7 Nme6 Ntpcr Rrm2 Tyms Rrm2b Nme3 Nme2 Nme4 Nme1 Dtymk L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis Aldh18a1 Pycr2 Pycr1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gstp1 Gsta3 Gsta1 Gsta2 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation Impdh2 Impdh1 Pnp Gda Ada Nt5c1a Xdh Nt5e Nt5c3a L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis Cbs Cth Ahcy Mat2a Mat1a L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle Enoph1 Adi1 Kyat1 Mri1 Srm Mat2a Apip Mat1a D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Synj2 Inppl1 Inpp5f Synj1 Inpp5a Bpnt2 Impa2 Ocrl Impa1 Inpp5k Inpp1 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation Acadsb BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Zfyve16 Bmpr2 Bmp2 Smad4 Acvr2a LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Ltc4s Dpep2 Lta4h Gstm4 Alox5 Dpep1 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis Hsd3b1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis Glud1 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II Rbp4 Rbp1 Xdh GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclc Gss Gclm DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation Maoa Maob Comt Aldh3a2 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis Alox15 Ephx3 Alox12 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I Got1l1 Got1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis St3gal5 Ugt8 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I Sord PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate Ldhb Ldhc PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III Maoa Maob Aldh2 Aldh1b1 Aldh3b1 Aldh3a1 Sat2 Sat1 Aldh3a2 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1 Ckm Ckb QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) Qtrt2 Qtrt1 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation Mccc2 Hmgcll1 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Hmgcl Mccc1 Auh Ivd GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation Aspg Asrgl1 Aga Got1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation Maoa Aldh2 Adh6 Sult1a1 Ugt2b34l1 Aldh3a2 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis Adsl Ak3 Ak2 Ak4 Adss2 Ak7 Ak8 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II Plaat3 Plaat1 Plaat5 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Kmo Ido2 Ido1 Tdo2 Haao Kynu UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis Uxs1 Ugdh PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases Pla2g10 Plcb4 Plcb3 Plcb2 Plcb1 Plcg1 Plcg2 Plaat3 Plaat1 Plaat5 Plch2 Pla2g2e Plcd1 Pla2g2d Plcd4 Pla2g2f Plcd3 Pla2g2a Pla2g4e Pla2g4d Pld4 Pla2g4a Pld6 Pld1 Pld3 Plb1 Plcz1 Pld2 Pla2g12a Plce1 Pnpla8 Pla2g5 Pla2g3 Pla2g6 Pla2g1b Oc90 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis Srd5a1 Srd5a2 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I Sqle Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Tm7sf2 Hsd17b7 Nsdhl Lbr OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis Gclc Gss Gclm Got1 COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis Pank3 Pank1 Ppcdc Coasy SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation Aldoa Tkfc Khk Tpi1l2 Aldob Aldoc PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis Prps1 Prps2 Prps1l1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage Cda Tk2 Tyms Dck Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 Dtymk Nme7 Nme6 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis Chkb Pcyt1b Pcyt1a Chka Chpt1 Cept1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization Maoa Maob Aldh2 Adh6 Sult1a1 Qprt Ugt2b34l1 Nadsyn1 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp1a2 Aanat Tph2 Ddc Tph1 Asmt Cyp2a3 Gcdh Echs1 Tdo2 Acat1 Acat2 Haao Kynu Aldh3a2 Aldh8a1 Nmnat1 Kmo Akr1a1 Ido2 Nmnat2 Acmsd Ido1 Dhtkd1 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) Hsd17b4 Acaa1b Hsd17b10 Acsbg1 Hadh Slc27a2 Acsbg2 Ehhadh Echs1 Acox1 Acox2 Scp2 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine Akr1a1 Maob Ddc Aldh3a2 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging Lars2 Gars1 Qars1 Lars1 Farsa Farsb Cars1 Vars2 Wars2 Aars2 Rars1 Wars1 Aars1 Rars2 Kars1 Sars2 Sars1 Fars2 Eprs1 Nars1 Nars2 Tars3 Tars2 Iars1 Tars1 Hars1 Pars2 Dars2 Yars2 Yars1 Dars1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Amdhd2 Gnpda2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis Tat SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage Adsl Impdh2 Impdh1 Adk Ak3 Gmps Rrm2 Ak2 Ak4 Rrm2b Adss2 Ak7 Nme3 Nme2 Ak8 Nme4 Nme1 Guk1 Nme7 Hprt1 Nme6 Aprt Pnp Ada SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Gdf1 Kdsr PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP Nme7 Nme6 Ntpcr Rrm2 Tyms Rrm2b Nme3 Nme2 Nme4 Dctd Nme1 Dtymk UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis Nme7 Nme6 Ctps2 Ctps1 Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine Shmt2 Aldh7a1 Chdh Shmt1 Bhmt Dmgdh TCA CYCLE%BIOCYC%PWY66-398 TCA cycle Sdhd Idh3b Sdhc Cs Sdhb Idh3g Sdha Suclg1 Suclg2 Ogdh Aco2 Mdh1 Mdh2 Dld Fh Idh3a Dlst N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis Emg1 Tsr3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation Hsd17b10 Acsbg1 Hadh Slc27a2 Acsbg2 Hadha Hadhb Echs1 Acaa2 Eci1 Scp2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Gdf1 Kdsr ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) Elovl7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II Sord Adh1 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis St3gal5 B3galt5 B3galt1 B3gnt5 Ugcg Fut2 B4galt6 St6gal1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation Sdsl TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling Pcbd1 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis Srm TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis Gch1 Spr Pts L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) Gcdh Echs1 Tdo2 Acat1 Haao Acat2 Kynu Aldh8a1 Kmo Ido2 Acmsd Ido1 Dhtkd1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation Oga Ogt CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis Hccs RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I Rbp4 Rbp1 Aldh1a2 Aldh1a1 Aldh1a3 Rdh16 Sdr16c5 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide St8sia2 B4galt1 Fut1 Abo2 B4galt2 B4galt3 Fut9 Chst1 St3gal4 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation Nme7 Nme6 Nme3 Nme2 Nme4 Nme1 Cmpk2 Cmpk1 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation Dpys Dpyd Cda Upp1 Upp2 Upb1 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) Dio3 Dio1 Dio2 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) Acsl1 Acsm3 Acsm4 Fads2 Elovl5 Acsm5 Fads1 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B3gnt2 B4galt1 B4galt2 B4galt3 Gcnt3 Gcnt2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) Eci1 Eci2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis Pklr Pfkl Pkm Pfkm Pfkp Bpgm Hk3 Gpi Eno1 Gck Gapdhs Aldob Hk2 Aldoc Eno3 Eno2 Aldoa Pgk1 Pgam2 Tpi1l2 Pgk2 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) Cbs Cth HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B3galt5 B3gnt2 Lalba Fut2 B4galt1 B4galt2 B4galt4 Gcnt3 St6gal1 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation Impdh2 Impdh1 Pnp Xdh Nt5e HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Fech Cpox Urod Ppox MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle Cpt1a Cpt2 Cpt1b Cpt1c Slc25a20 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis Trpc1 Tyrp1 Tyr Dct FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) Oxsm Acsf3 Mcat Ndufab1 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis B3galt5 St3gal2 Ugcg Fut2 A4galt Fut1 B3galnt1 B4galt6 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation Treh Hk3 Gck Hk2 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis Cyp2c11 Ephx3 Ephx1 Ephx2 Ephx4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) Rdh10 Rpe65 Rbp2 Rbp3 Dhrs9 Lrat Rlbp1 Rbp4 Rbp1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis Hsd3b1 Srd5a1 Srd5a2 Hsd17b3 Cyp17a1 Akr1c3 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis Impdh2 Nme7 Nme6 Impdh1 Gmps Nme3 Nme2 Nme4 Nme1 Guk1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis Rdh10 Rbp2 Dhrs9 Lrat Ces4a Ces5a Pnlip Lipc Ces2h Ces1d Bco1 Rbp4 Rbp1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis Alox15 Ephx3 Ptgs2 Gpx4 Cyp2d4 Alox12 Alox5 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis Pip5k1b Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pik3r2 Pik3r3 Pik3r4 Pi4kb Cdipt Pik3cg Pik3cb Pik3cd Pikfyve Pi4k2b Pik3c3 Pik3c2b Pik3c2a Pik3c2g Sacm1l Fig4 Pi4k2a Pip5k1c UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Gnpnat1 Uap1 Pgm3 Hk3 Gpi Gnpda2 Gck Hk2 Gale 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I Aldh5a1 Abat CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Cdo1 Got1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis Acsl1 Acsbg1 Acot2 Acot3 Slc27a2 Elovl6 Acot4 Acot7 Hsd17b12 Acsbg2 Elovl7 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation Abat TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation Hoga1 Prodh2 Got2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation Cyp4f4 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) Fads2 Elovl5 Hsd17b12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis Lss SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Acsl1 Acsbg1 Slc27a2 Acsbg2 Ptgr1 Acer1 Acer2 Asah2 Asah1 Sphk2 Sphk1 Sgpp2 Sgpp1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Pnp Ada Pgm2 PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation Cda Upp1 Upp2 Tymp D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Mtmr14 Pip4k2c Pip4k2a Plch2 Plcd1 Plcd4 Plcd3 Plcb4 Plcb3 Pip4p2 Pip4p1 Plcz1 Plcb2 Plce1 Plcb1 Mtmr3 Plcg1 Plcg2 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis Akr1c1 Srd5a1 Akr1c2 Srd5a2 Akr1c3 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I Mthfd1l Shmt2 Mthfd2l Shmt1 Aldh1l2 Mthfd2 Mthfs Mthfr Mthfd1 Mtr GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation Gk5 Gk Gk2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation Mpi L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation Ahcy Mat2a Mat1a ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III Hprt1 Pnp Ada REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation Gpx3 Gpx7 Cat Sod3 Sod2 Gpx6 Sod1 Gpx5 Gpx8 Gpx2 Gpx1 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation Pnp Ada Nt5c1a Xdh Nt5e Nt5c3a ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) Cyp4x1 Cyp2e1 Cyp2u1 Cyp2a3 Cyp2s1 Akr1b10 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis Aldh9a1 Shmt1 Tmlhe Bbox1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Synj2 Inppl1 Itpk1 Inpp5d Itpka Synj1 Inpp5a Itpkc Itpkb Ipmk Ocrl Ippk Inpp5k LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis Alox15 Gpx4 Alox12 Alox15b Alox5 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation Lipg Dagla Lipe Lipf Lpl Pnpla3 Cel Daglb Pnliprp2 Pnpla2 Pnlip Lipc CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Nanp Nans Cmas Gne CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis Ptpmt1 Crls1 Pgs1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation Comt CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis Gamt Gatm UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) Ugdh GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis Nme7 Nme6 Rrm2 Rrm2b Nme3 Nme2 Nme4 Nme1 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis Pfkfb4 Pfkfb3 Tigar Pfkfb2 Pfkfb1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis Ggps1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) Shmt2 Tyms ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis Nme7 Nme6 Rrm2 Rrm2b Nme3 Nme2 Nme4 Nme1 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Nmnat1 Nmnat2 Qprt Nadsyn1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I Rnmt Rngtt DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis Cbr1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I Ptdss1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) Fads2 Elovl5 Hsd17b12 Elovl7 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) St8sia2 B3gnt2 B4galt1 B4galt2 St6gal2 B4galt3 Gcnt3 St6gal1 Gcnt2 St3gal4 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III Cyp2e1 Aldh2 Acss2 Acss3 Acss1 Aldh3a2 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II Aldh2 Acss2 Acss3 Acss1 Aldh3a2 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation Bckdhb Bckdha Dbt Dld Mcee Pccb LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III Glb1 Lct Glb1l3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV Aox1 Cyp4x1 Fmo3 Cyp2u1 Fmo2 Cyp2a3 Cyp2s1 Fmo5 Fmo4 Ugt1a5 Ugt2b34l1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) Galt Galm Galk1 Pgm2 Pgm1 Gale UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Gnpnat1 Uap1 Pgm3 Hk3 Gpi Gfpt1 Gfpt2 Gck Hk2 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis Gpt2 Gpt INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis Adsl Atic Paics L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) Aldh7a1 Dhtkd1 Aass Aadat L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis Sars2 Sars1 Sephs1 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation Slc27a2 Hacl1 Phyh Aldh3a2 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Fdps Ggps1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis Tyw3 Tyw1 Lcmt2 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I Napepld Plaat1 Plaat5 Pla2g1b Enpp2 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation Acadsb Echs1 Acat1 Acat2 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis Nmnat1 Kmo Ido2 Nmnat2 Ido1 Tdo2 Qprt Haao Nadsyn1 Kynu LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation Acsl1 Acsbg1 Acsl3 Slc27a2 Acsbg2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) Tst 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis Dagla Ddhd1 Daglb Plcb1 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) N6amt1 Pnp Slc20a2 Slc20a1 Trmt112 Aqp9 Slc34a2 Aqp7 Slc2a1 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation Cyp4x1 Cyp2u1 Cyp2a3 Cyp2s1 Cyp2b2 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I Pgm2 Pgm1 Ugp2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis Lta4h Ptgs2 Alox5 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis Aldh18a1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation Papss2 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis Gmppa Pmm2 Gmppb Pmm1 Gpi Mpi CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Sqle Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Tm7sf2 Hsd17b7 Nsdhl Lbr UREA CYCLE%BIOCYC%PWY-4984 urea cycle Asl Cps1 Ass1 Otc GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) Shmt2 Shmt1 Bhmt Dmgdh SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) Tst Suox HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis Fech Cpox Alad Urod Alas2 Ppox Hmbs Uros PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I Mcee Pccb L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation Bckdhb Bckdha Dbt Dld Sds Sdsl GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage Hprt1 Pnp CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle Asl Ass1 Nos3 Nos2 Nos1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation Cbs Cth Ahcy Bhmt Mcee Bhmt2 Pccb Mtr Bckdhb Cdo1 Bckdha Dbt Suox Dld Mat2a Mat1a Got1 TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis Alad Alas2 Hmbs Uros MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway Idi1 Hmgcs1 Pmvk Hmgcr Mvd Hmgcs2 Acat1 Acat2 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II Fmo1 Ado ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) Gsto1 Glrx DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis Agpat3 Lclat1 Agpat4 Plpp4 Agpat2 Mogat1 Plpp2 Plpp3 Plpp1 Dgat2 Plppr4 Agpat1 Dgat1 Plppr2 Plppr3 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Gpam Abhd5 Mboat2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis Ddc Th Dbh 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis Tyw3 Tyw1 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I Csad Fmo1 Cdo1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I Aprt MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle Mdh1 Mdh2 Got1 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor Atf2 Mapk8 Ccne1 Fkbp1a Mapk1 Irf2bp1 Ctnnb1 Map3k7 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Myc Cdc27 Akt1 Tp53 Skp1 Pdk1 Pard6a Dcp1a Rbx1 Prkcg Eid2 Prkcb Hgs Ube2d3 Prkcd Ube2d2 Ube2d1 Nup153 Btrc Cdc25a Atf3 Jund Sdc2 Pxn Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Ar Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Tp73 Jun Cops5 Vdr Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Ptk2 Stk11 Hspa8 Crebbp Smad2 Map4k1 Smad3 Snw1 Wwtr1 Sparc Smad4 Cdk6 Fnta Cdk4 Cdk2 Cul1 Cdc16 Cdk1 Junb Daxx Smad6 Smad7 Hnf4a Rhoa Tgif1 Ing2 Xpo1 Ctcf Hdac1 Foxo4 Tfdp2 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Zeb1 Rbl2 Zeb2 Rbl1 Anapc10 Foxh1 Smurf2 Smurf1 Skil Pik3r1 Crk Pik3r2 Lef1 Stk11ip Nfyb Nfya Ppm1a Nfyc Prkar1b Strap Hoxa7 Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Arrb2 Cd44 Runx2 Rb1 Mapk14 Tgfbr3 Prkar2a Map2k3 Mef2c Brca1 Zfyve9 Rock1 Tgfbr1 Cdkn1a E2f5 Tgfbr2 BDNF%IOB%BDNF BDNF Mapk8 Mapk1 Mapk3 Akt1 Mapk9 Shc4 Shc1 Irs1 Plcg1 Irs2 Ptk2b Elk1 Gsk3b Ntrk2 Ntrk1 Raf1 Foxo3 CCR1%IOB%CCR1 CCR1 Gna14 Ptk2 Rela Ccl7 Ccl5 Mapk14 Pxn Mapk1 Ccl4 Ccl3 Nfkb1 Stat1 Mapk3 Ptk2b Prkcd Ccr1 Zap70 Creb3 Src LEPTIN%IOB%LEPTIN Leptin Pde3a Itgav Socs7 Rps6kb1 Ptpn11 Slc2a4 Jak3 Jak2 Pik3r1 Rps6 Egfr Pik3r2 Khdrbs1 Sp1 Lep Prkce Stat3 Grb2 Lepr Ptk2 Mapk1 Mapk14 Mapk3 Irs1 Irs2 Prkcd THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin Shc1 Mapk1 Stat3 Map2k1 Stat5b Atxn2l Mpl Gab1 Mapk3 Jak2 Foxo3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor Lyn Yes1 Kitlg Stat5a Tec Fes Hras Pik3r1 Crk Pik3r2 Atf2 Mapk8 Mapk1 Mapk14 Akt1 Shc1 Plcg1 Gsk3b Prkcb Raf1 Src Rela Stat1 Rps6kb1 Ptpn11 Jak3 Jak2 Rps6 Grb2 Jun Stat5b Socs1 Mitf Socs5 Socs4 Socs6 Matk Crkl Ptpru Gys1 Csf2rb Cltc Sh3kbp1 Cblb Mad2l1 Fgr Hck Dok1 Wipf1 Rps6ka1 Tnfrsf10b Kit Prkca Spred1 Il7r Sos1 Spred2 Inpp5d Rasa1 Eif4ebp1 Cbl Mtor Epor Abl1 Fyn Grap CCR7%IOB%CCR7 CCR7 Mapk8 Rela Foxo1 Mapk14 Mapk1 Cfl1 Ccl19 Ccl21 Ccr7 Rps6kb1 Adrb2 Mapk3 Akt1 Plcg1 Ptk2b Gsk3b Mtor Foxo3 WNT%IOB%WNT Wnt Yes1 Ilk Mark2 Wnt5a Ctbp1 Cdh1 Ywhab Rac1 Lef1 Pi4k2a Ppp1ca Nfatc2 Sfrp2 Ppp2ca Sfrp1 Daam1 Rspo1 Prkaca Dkk1 Mesd Pax2 Gsk3a Frzb Arrb2 Mapk8 Dixdc1 Chd7 Axin1 Ror1 Ror2 Ctnnb1 Lrp1 Map3k7 Arhgef4 Lrp6 Csnk1a1 Nlk Lrp5 Wnt3a Dvl1 Gpc3 Akt1 Dvl3 Wnt7a Wnt2 Wnt1 Wnt4 Wnt3 Tcf7l2 Prkcg Fzd1 Fzd5 Gsk3b Prkcb Jup Fzd4 Fzd6 Prkcd Kremen1 Fzd9 Fzd8 Smad1 Apc Pin1 Tcf4 Pip5k1b Jun Ccnd1 Cdk6 Prkca Rhoa FAS%IOB%FAS Fas Lyn Satb1 Ripk1 Casp1 Bmx Map2k2 Wee1 Diablo Bcl2 Bax Fas Pkn2 Vim Faslg Pkn1 Dffa Rac1 Mapk1 Csnk1a1 Rock1 Mapk3 Cdc27 Akt1 Gsk3b Prkcd Traf3 Psme3 Nedd4 Faf1 Eif2ak2 Arhgdib Stk24 Csnk2a1 Parp1 Traf2 Plec Csnk2b Parg Prkn Rfc1 Mst1 Bcl2l1 Xiap Glrx Casp8ap2 Eif4b Gtf3c3 Map2k1 Lck Tcp1 Btk Anxa4 Fadd Top1 Met Csnk1e Cast Dedd Cd59b Eif3j Max Srf Aifm1 Uso1 Ptpn6 Stk4 Stk3 Ripk2 Prkdc Numa1 Hspb1 Cflar Eif2s1 Bid Ube4b Daxx Pak2 Casp8 Mbd4 Casp7 Rasa1 Tial1 Tia1 Casp9 Casp4 Casp3 Casp6 Fyn Fastk Casp2 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Yes1 Vim Erbb2 Pik3r1 Clca1 Rpsa Ywhab Pik3r2 Ywhah Rac1 Ywhae Dsp Eif4e Lama5 Cd151 Itgb4 Lama2 Lama3 Mst1r Mylk3 Ywhaz Pik3r3 Col17a1 Itga6 Ntn1 Ephb2 Pak1 Lamb2 Lamb3 Pik3cg Sfn Lamb1 Pik3cb Pik3cd Rtkn Bad Eif6 Lamc1 Akt1 Shc1 Irs1 Irs2 Prkcd Src Ar Ptpn11 Plec Egfr Grb2 Tp73 Met Ptk2 Smad2 Smad3 Prkca Rhoa Eif4ebp1 Mtor Casp3 Abl1 Fyn NGF%IOB%NGF NGF Dnaja3 Prkci Frs2 Sp1 Mapk1 Elk1 Map2k1 Mapk3 Creb1 HEDGEHOG%IOB%HEDGEHOG Hedgehog Ccnb1 Hhip Stk36 Kif7 Med6 Smo Sufu Kif27 Ywhae Prkaca Arrb2 Ctnnb1 Med23 Dhh Ihh Gli1 Gli2 Shh Grk2 Ptch1 Dyrk1a Sap18 Boc Med12 Med1 GM-CSF%IOB%GM-CSF GM-CSF Lyn Yes1 Stat5a Map2k2 Fes Pik3r1 Pik3r2 Map2k6 Bcar1 Gsk3a Mapk8 Mapk1 Mapk14 Tgfbr3 Map2k3 Mapk3 Bad Akt1 Creb1 Mapk9 Shc1 Plcg1 Elk1 Gsk3b Raf1 Pxn Stat1 Ikbkb Pdia3 Slc2a1 Prdx3 Rps6kb1 Stam2 Syk Rack1 Jak2 Vav1 Tgfb1 Sptan1 Rps6ka2 Pfn1 Csf2 Ezr Ganab Stat3 Stam Grb2 Cct5 Ptprc Map2k1 Dpysl2 Stat5b Sh2b2 Nfkbia Gab1 Bcl3 Park7 Chuk Crkl Csf2rb Ptpn6 Hck Prkca Cbl CCR9%IOB%CCR9 CCR9 Madcam1 Mapk8 Msn Foxo1 Cd226 Itgb7 Mapk14 Mapk1 Ccl25 Itga4 Ccr9 Rps6kb1 Mapk3 Akt1 Cdh1 Ezr Gsk3b Rdx TIE1 TEK%IOB%TIE1 TEK TIE1 TEK Ptk2 Bmx Stat5a Pak1 Mapk14 Mapk1 Map2k2 Fes Nos3 Tie1 Dok2 Tek Nck1 Mapk3 Akt1 Shc1 Elk1 Map2k1 Stat5b Raf1 CCR5%IOB%CCR5 CCR5 Rela Ccl7 Ccl5 Stat5a Ccl4 Cfl1 Stat1 Ikbkb Syk Pik3r1 Stat3 Grb2 Nfkbia Chuk Mapk1 Mapk14 Ptpn6 Psma5 Mapk3 Afp Ccl11 Cd4 Akt1 Ccl12 Ccl2 Ccr5 Ptk2b IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha Foxo1 Stat5a Stat1 Rps6kb1 Vav1 Rps6 Crk Stat3 Eif4b Stat5b Map2k6 Nfkbia Crkl Map2k3 Akt1 Irs1 Stat6 Erbb3 Stat4 Irs2 Pla2g4a Ifnar1 Jak1 Eif4ebp1 Arhgap30 Cbl Prkcq Mtor Map2k4 Prkcd Rps6ka5 Zap70 Stat2 TRAIL%IOB%TRAIL TRAIL Dap3 Bex3 Ripk1 Rela Chek2 Casp1 Ikbkg Tnfrsf11b Prkaa1 Tradd Nfkb1 Diablo Bak1 Bcl10 Bax Mcl1 Csnk2a1 Cycs Parp1 Vdac1 Traf2 Tnfsf10 Apaf1 Irf5 Atm Xiap Nfkbia Fadd Mapk1 Mapk14 Ctnnb1 Aifm1 Map3k7 Mapk3 Prkdc Akt1 Creb1 Cflar Tnfrsf10b Bid Casp8 Casp7 Cbl Casp3 Ctsb H2ax Src Casp2 NOTCH%IOB%NOTCH Notch App Fhl1 Hivep3 Lef1 Hdac2 Mfng Numb Ccn3 Skp2 Hes6 Tle1 Maml3 Notch4 Psenen Notch1 Notch2 Notch3 Psen1 Pofut1 Psen2 Ncstn Mapk1 Aph1b Ncor2 Dll1 Dll3 Dll4 Itch Maml1 Ring1 Mapk3 Maml2 Furin Hes1 Jag2 Jag1 Skp1 Cirsr Yy1 Lfng Tcf3 Rbx1 Gsk3b Smad1 Rela Nfkb1 Jak2 Stat3 Smad3 Snw1 Smad4 Cul1 Hdac1 M-CSF%IOB%M-CSF M-CSF Ripk1 Stat5a Vim Ptpn11 Pik3r1 Stat3 Grb2 Stat5b Fadd Mitf Ptk2 Akt1 Shc1 Ets2 Casp8 Csf1r Ptk2b Inpp5d Inppl1 Grap2 Tfe3 Cbl Pstpip2 Dnm1 Prkcd Csf1 EGFR1%IOB%EGFR1 EGFR1 Mapk8 Mapk1 Mapk3 Myc Akt1 Tp53 Prkcg Prkcb Hgs Prkcd Jund Pxn Dab2 Sp1 Jun Cav1 Ptk2 Stk11 Smad2 Smad3 Cdk2 Cdk1 Rhoa Tgif1 Hdac1 Zfyve16 Foxo1 Fos Pik3r1 Crk Pik3r2 Bcar1 Ap2b1 Mapk14 Map2k3 Mapk9 Shc1 Plcg1 Irs2 Ptk2b Elk1 Gsk3b Raf1 Src Rela Nfkb1 Stat1 Rps6kb1 Ptpn11 Jak2 Egfr Khdrbs1 Stat3 Grb2 Map2k1 Stat5b Gab1 Socs1 Crkl Cltc Sh3kbp1 Cblb Dok1 Rps6ka1 Kit Prkca Sos1 Rasa1 Eif4ebp1 Cbl Mtor Abl1 Fyn Lyn Stat5a Hras Cfl1 Ctbp1 Cdh1 Ywhab Rac1 Gsk3a Arhgef4 Jup Nedd4 Plec Lck Anxa4 Met Cd59b Ptpn6 Casp9 Ripk1 Map2k2 Bcl2 Pkn2 Vim Erbb2 Dsp Itgb4 Ywhaz Pik3r3 Col17a1 Ephb2 Pak1 Pik3cg Pik3cb Pik3cd Bad Creb1 Prkci Frs2 Grk2 Dyrk1a Stam2 Vav1 Rps6ka2 Pfn1 Stam Nos3 Dok2 Nck1 Erbb3 Jak1 Rps6ka5 Stat2 Prkaa1 App Itch Inppl1 Dnm1 Atf1 Myl12b Il17rd Pard3 Mprip Prkd1 Eno1 Elk4 Eps8 Gja1 Rpl30 Tfg Ralb Otud6b Araf Plcg2 Arhgap5 Itsn2 Arap1 Zdhhc5 S100a10 Snca Pitpna Flot2 Flot1 Errfi1 Myo6 Scrib Prkcz Tfrc Pik3c2b Antxr1 Arf4 Braf Clta Cyld Ahnak Rplp0 Snx33 Tkt Baiap2l1 Rbck1 Htt Appl2 Caskin2 Stx4 Rps2 Pygb Gsn Pdzd11 Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Abi1 Ensa Frk Hipk2 Hipk3 Map3k14 Eef1a2 Socs3 Grb14 Grb10 Phpt1 Stip1 Map3k4 Pias3 Cdh3 Cdh2 Plekhn1 Tom1 Eps15 Map3k3 Map3k2 Magi1 Map3k1 Hat1 Pkp2 Hnrnpdl Ldlr Pkp3 Flnb Anxa2 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Abl2 Prp4k Slc38a2 Ptpre Tnk2 Ptpra Cdk5 Alb Pdlim1 Sh3bgrl Nck2 Slc12a7 Acp1 Mt-co2 Sh3gl3 Adam9 Epha1 Epha2 Epha4 Itgb1 Pkm Dsg2 Sh3gl2 Ctnnal1 Wbp2 Atp1a1 Ephb1 Cebpb Cebpa Ephb3 Ptpn1 Slitrk6 Csk Arhgap32 Arhgap35 Rbbp7 Tagln2 Pten Ralbp1 Bcar3 Slc25a5 Spart Nectin1 Rps10 Ppp2r3a Prkaa2 Scamp3 Tns4 Tns2 Tns1 Krt8 Cblc Krt7 Phlpp1 Actb Actr2 Actr3 Tln1 Rin1 Vasp Arhgef7 Arhgef5 Hnrnpr Sdc4 Insr Sdc3 Atp5f1c Usp6nl Pttg1ip Slc5a5 Snx5 Tollip Ptk6 Kirrel1 Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Dyrk1b Dcbld2 Ptprf Git1 Vav3 Cdv3 Laptm4a Plekha6 Anks1a Vav2 Mink1 Actn1 Actn4 Plscr1 Gprc5a Aldoa Map2k7 Map2k5 Limd1 Cstb Git2 Krt18 Krt17 Racgap1 Cttn Mpzl1 Axl Ctnnd1 Nedd9 Tjp2 Cavin1 Cavin2 Sdcbp Cc2d1a C8h11orf52 Prkx Ap2a1 Vcl Cysrt1 Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Efnb2 Cav2 Sirpa Ralgds Dlg3 Crim1 Ddx6 S100a11l1 Peak1 Afap1l2 Ddx3x Rbm3 Sfpq Pdpk1 Dapp1 Asap1 Iqgap1 Baiap2 Lsr Epn2 Epn1 Rps6ka3 Dyrk4 Epn3 Usp31 Dyrk3 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Trim29 Eif4g1 Dock1 Phldb2 Ptpn18 Rgs16 Ptpn12 Mta2 Snrpd2 Egf Spry2 Spry1 Reps2 Prag1 Spry4 Pebp1 Ptpn23 Hspe1 Zpr1 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor Ppp1ca Ccne1 Ncor2 Ctnnb1 Akt1 Cdc25a Tcf4 Prkd1 Pxn Brinp1 Nr2c2 Nr2c1 Nrip1 Parp1 Ahr Ar Hsp90aa1 Uxt Pias4 Ube2i Kat5 Kat7 Gtf2f2 Sp1 Gtf2f1 Pias1 Sf1 Ccnh Prdx1 Jun Tle5 Dapk3 Flna Ccnd1 Cdc37 Cav1 Pa2g4 Senp1 Esr1 Top1 Cdc25b Nono Bag1 Gtf2h1 Hspa8 Rbak Psmc3ip Ccnd3 Pelp1 Smad3 Cdk9 Xrcc6 Cdk7 Smad4 Hspa5 Xrcc5 Mdm2 Fhl2 Gsn Pou2f1 Hspb1 Prmt1 Calr Nr0b2 Spdef Daxx Etv5 Lpxn Svil Casp8 Ddc Il6st Casp7 Tgif1 Tmf1 Arnt Hsp90b1 Zmiz2 Hdac1 Zmiz1 Casp3 Rnf4 Foxa1 Magea13 Ncoa2 Pias3 Ncoa4 Nsd2 Casp1 Ncoa6 Nsd1 Pak6 Pnrc1 Cox5b Tgfb1i1 Slc25a4 Vip Rchy1 Ran Pik3r1 Ncoa1 Runx2 Rb1 Brca1 Cebpa Gsk3b Pten Src Rela Rack1 Egfr Stat3 Park7 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 Atf2 Lyn Stat5a Mapk1 Cblb Mapk3 Gab2 Creb1 Akt1 Cebpa Stat3 Jun Cbl Gab1 Atf1 CD40%IOB%CD40 CD40 Lyn Mapk8 Mapk14 Mapk1 Ikbkb Fgr Plcg2 Mapk3 Syk Myc Jak3 Akt1 Pik3r1 Mapk9 Stat3 Jun Map2k1 Lck Nfkbia Fyn Chuk TNFSF3%IOB%TNFSF3 TNFSF3 Nfkb2 Lta Rela Ltb Traf3 Ltbr Nfkb1 Jun Nfkbia Traf2 Tnfrsf1b Tnfrsf1a ID%IOB%ID ID Atf3 Rb1 Elk4 Smad3 Rbl2 Rbl1 Cdk2 Hes1 Myod1 Tcf3 Psmd4 Tcf7l2 Elk3 Elk1 Id2 Id1 Id4 Id3 Myf5 G-CSF%IOB%G-CSF G-CSF Lyn Stat5a Stat1 Ptpn11 Syk Gab2 Jak2 Stat3 Grb2 Stat5b Lck Il3ra Csf3r Pom121 Fth1 Pla2g1b Csnk1e Syp Sod1 Rel Mapk1 Mapk14 Cish Cdkn1b Mapk3 Hck Cdk2 Akt1 Rps6ka1 Prkci Shc1 Inpp5d Jak1 Cbl Socs3 EPO%IOB%EPO EPO Foxo1 Stat5a Map2k2 Ptpn11 Syk Jak2 Vav1 Stat3 Jun Map2k1 Stat5b Sh2b2 Gab1 Braf Gsk3a Crkl Mapk1 Hcls1 Nos3 Sgk1 Mapk3 Bad Akt1 Irs2 Mtor Raf1 Epor Rps6ka5 Foxo4 Foxo3 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma Stat5a Stat1 Plcg2 Jak2 Crk Egfr Stat3 Mapk8 Crkl Mapk1 Mapk14 Spi1 Ifngr1 Irf1 Irf2 Mapk3 Irf8 Mapk11 Akt1 Stat6 Cebpb Pla2g4a Jak1 Cbl Prkcq Raf1 TNFSF1%IOB%TNFSF1 TNFSF1 Rela Traf3 Ikbkg Nfkb1 Tnfrsf14 Tnfrsf1b Tnfrsf1a Akt1 Nfkb2 Lta Ltbr Jun Nfkbia TNFALPHA%IOB%TNFALPHA TNFalpha Fancd2 Psmd3 Psmd2 Stat5a Ikbkg Elp1 Psmd1 Spag9 Tradd Usp11 Glb1 Smarcc2 Prc1 Smarcc1 Rnf25 Map3k11 Mark2 Lrpprc Mtif2 Ywhab Hdac2 Ddx3x Mapk8 Mapk1 Map3k7 Mapk3 Akt1 Skp1 Ube2d3 Prkcd Ube2d2 Btrc Traf3 Faf1 Rpl30 Brinp1 Nr2c2 Csnk2a1 Traf2 Hsp90aa1 Ube2i Jun Prkcz Cops5 Flna Cdc37 Cav1 Fadd Crebbp Cdk9 Hspb1 Cul1 Cflar Bid Casp8 Casp7 Map3k14 Hdac1 Casp3 Casp2 Ripk1 Map3k3 Map3k2 Map3k1 Pkn1 Tnfrsf1b Tnfrsf1a Nfkb2 Ywhah Ywhae Map2k6 Ywhaz Rel Rb1 Mapk14 Nkiras1 Creb1 Mapk9 Rpl4 Nkiras2 Tbkbp1 Trib3 Map3k8 Rps11 Tnf Fbl Tbk1 Unc5cl Akt2 Dpf2 Kcnq1 Azi2 Polr1b Polr1c Src Polr1a Usp2 Rela Fbxw11 Polr1e Tank Gtf2i Hsp90ab1 Nfkb1 Actl6a Stat1 Smarce1 Ikbkb Polr2sl1 Tifa Inpp5e Rps6kb1 Rasa3 Ptpn11 Nfkbiz Syk Papola Rack1 Glg1 Bag4 Egfr Ripk3 Cradd G3bp2 Dcaf7 Cops3 Nfkbib Nfkbie Nlrp4 Kpna6 Mcc Kpna3 Nfkbia Kpna2 Bcl3 Gab1 Ccnt1 Tab2 Chuk Traf7 Mcm7 Traf4 Pfdn2 Traf6 Birc2 Tnfrsf8 Ikbke Ywhag Psmd12 Smarcb1 Psmd13 Alpl Rasal2 Dok1 Akap8 Psmb5 Ppp6c Rpl8l1 Fkbp5 Mcm5 Smarca4 Tnip2 Psmc2 Psmc1 Psmc3 Polr2h Pdcd2 Map2k5 Nsmaf Zfand5 Rps6ka5 Trpc4ap Psmd7 Psmd6 Mapkapk2 GDNF%IOB%GDNF GDNF Ptk2 Pxn Map2k2 Rps6ka3 Rps6kb1 Dok1 Ret Th Crk Cdk1 Cdc25c Ptk2b Jun Map2k1 Nfkbia Raf1 Gab1 Bcar1 Fyn Met TNFSF8%IOB%TNFSF8 TNFSF8 Nfkb2 Rela Traf3 Rel Mapk1 Tnfrsf8 Nfkb1 Bcl3 Akt1 CXCR4%IOB%CXCR4 CXCR4 Lyn Map2k2 Cfl1 Pik3r1 Crk Ywhab Pik3r2 Itk Rac1 Cxcr4 Itgb2 Icam1 Gnai1 Tff2 Lcp2 Cxcl12 Gna13 Grk6 Bcar1 Fyb1 Ackr3 Vcam1 Limk1 Arrb2 Usp14 Mapk1 Map2k3 Mapk3 Bad Creb1 Plcg1 Ptk2b Elk1 Gsk3b Prkcd Zap70 Atf1 Src Rela Pxn Nfkb1 Stat1 Ikbkb Rps6kb1 Plcg2 Ptpn11 Jak3 Jak2 Vav1 Rps6 Egfr Rps6ka2 Stat3 Sdc4 Ptprc Map2k1 Lck Stat5b Nfkbia Chuk Ptk2 Hspa8 Crkl Cblb Ptpn6 Nck1 Dok1 Vav2 Ccr5 Stat4 Rhoa Inpp5d Rasa1 Cbl Stat2 Fyn Foxo3 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Il4 Cabin1 Pou2f1 Ifng Cd40lg Akap5 Faslg Csf2 Junb Nfatc3 Nfatc2 Ptgs2 Fosl1 Jun Chp1 Rcan2 Fkbp1a Il2ra Prkaca Fos Batf3 Il2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Tfe3 Dcp1a Rbl1 Foxh1 Irf7 Gata3 Serpine1 Skil Med15 Atf3 Dlx1 Nr3c1 Myod1 Max Snip1 Cebpb Ar Ncoa2 Ncoa1 Il5 Sp1 Gsc Sap18 Cited1 Sp3 Runx3 Runx1 Runx2 Kat2a Cbfb Vdr Rbbp7 Esr1 Hspa8 Crebbp Smad2 Smad3 Mef2c Smad4 Zbtb17 Cdk4 Cdk2 Lamc1 Tcf3 Cdkn1a E2f5 Smad7 Jun Fos Atf2 Il10 Hnf4a Nkx2-5 Pias3 Tgif1 Hdac2 Pias4 Ifnb1 Ctbp1 Myc Hdac1 Foxg1 Akt1 Foxo4 Cdkn2b Foxo3 Foxo1 Creb1 Col1a2 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Il24 Il17f Il23a Il17a Nfkbia Rela Stat5a Il18r1 Il1b Stat3 Stat1 Pik3r1 Alox12b Il2 Ifng Socs3 Stat4 Il18 Il12b Il19 Cd3e Tnf Il6 Cd4 Ccl12 Cxcl9 Itga3 Il23r Nfkb1 Jak2 Cxcl3 Nos2 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Ube2i Mdm2 Ran Pias1 Pias2 Hdac1 Ranbp2 Xpo1 Hdac4 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Nfkbia Rela Pik3r1 Mapk8 Mapk1 Ilk Jun Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Fos Cd44 Vav3 Gsn Syk Mmp2 Ptk2b Mmp9 Map3k1 Plau Rock2 Chuk Map3k14 Nfkb1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Mapk1 Mapk3 Fkbp1a Smad4 Tgfb1 Tgfb3 Acvrl1 Id1 Arrb2 Smad7 Ppp1ca Csnk2b Cav1 Gdf2 Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Acvr2a Inhba Acvr2b Smad5 Tgfbr1 Tgfbr2 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Shank3 Shc1 Rasa1 Irs1 Src Pxn Irs2 Grb10 Pdlim7 Gdnf Ptpn11 Gfra1 Pik3r1 Nck1 Rap1a Gab1 Frs2 Ptk2 Dok1 Dok4 Dok6 Grb2 Mapk8 Prkca Mapk1 Sos1 Jun Crk Hras Mapk3 Rhoa Bcar1 Prkaca Rac1 Ret Creb1 Grb7 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Mapk1 Col11a1 Mapk3 Col11a2 Fgf19 Cask Prkaca Ccl5 Bsg Hpse Ppib Col2a1 Sdcbp Col3a1 Col1a1 Mmp9 Mmp7 Col4a3 Col5a2 Col6a2 Mmp1 Tgfb1 Col4a1 Hgf Col5a1 Col4a5 Fgf23 Fgfr3 Fgfr4 Lama5 Sdc1 Met Col1a2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Nras Prkcb Rasa1 Rras Prkce Rasgrp3 Rasgrp4 Rasgrp1 Rasgrp2 Rin1 Grb2 Prkca Sos1 Hras Rasa2 Rabgef1 Camk2b Nf1 Rasal1 Dab2ip Kras Prkcz Plce1 Lgals1 Lgals3 Rasgrf2 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Incenp Aurkc Aurkb IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Shc1 Irs1 Irs2 Cebpb Il5 Sp1 Grb2 Col1a1 Socs3 Jak2 Stat5a Pik3r1 Socs1 Spi1 Stat6 Alox15 Socs5 Ets1 Jak3 Aicda Jak1 Fcer2 Il13ra1 Il13ra2 Arg1 Bcl2l1 Mybl1 Dok2 Irf4 Oprm1 Tff3 Lta Inpp5d Il4 Ptpn6 Thy1 Cbl Cd40lg Ccl17 Mtor Selp Ccl11 Rps6kb1 Pigr Egr2 Parp14 Mapk14 Il10 Il4r Il2rg Stat5b Bcl6 Fes Hmga1 Retnlg Akt1 Col1a2 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Shc1 Rela Ptpn11 Pik3r1 Jak3 Jak1 Grb2 Sos1 Bcl2l1 Il2ra Rac1 Il2 Mtor Rps6kb1 Il2rg Smpd1 Eif3a Hsp90aa1 Myc Sgms1 Rps6 Akt1 Gab2 Tert Prkcz Lck Nfkb1 Foxo3 Bcl2 E2f1 Ugcg SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Afdn Angpt1 Shc1 Lmo4 Irs1 Ngf Frs3 Egfr Gnai1 Raf1 Gnai3 Il6st Sdc2 Ptpn11 Ntf4 Ntf3 Pdgfrb Gab1 Ifngr1 Frs2 Vegfa Pdgfb Il6r Arhgap35 Nos3 Egf Grb2 Igf1 Sos1 Ntrk2 Map2k2 Ntrk1 Hras Map2k1 Ntrk3 Tek Igf1r Il6 Kras Jak2 Nras Stat1 Pik3r1 Jak3 Jak1 Rhoa Il2ra Prkaca Il2 Ifng Il2rg Gab2 Lck Bdnf NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Stat3 Myod1 Ar Ncoa1 Runx2 Neurog3 Ncor2 Bglap Arnt Ptf1a Ghr Crebbp Camk2d Hif1a Hey2 Maml1 Maml2 Parp1 Hes1 Twist1 Ascl1 Tcf3 Rb1 Hes6 Tle1 Gaa Kdm1a Rbbp8 Yy1 Notch1 Gata6 Ctbp1 Gata4 Gata1 Cd4 Hdac1 Cdkn1b Jak2 E2f1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itgb7 Itga6 Itga9 Itgb1 Itga2b Itgam Itgb4 Itga4 Itga1 Itgb2 Itga2 Itgal Itga10 Itgav Itgad Itgb8 Itga3 Itga7 Itga8 Itgax Itgb6 Itga5 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Incenp Golga2 Nudc Bora Kif2a Kif20a Fbxo5 Spc24 Ercc6l Fzr1 Pak1 Ppp1r12a Ect2 Bub1 Tubg1 Rhoa Cdc14b Cdc20 Ppp2ca Ppp1cb Ccnb1 Plk1 Gorasp1 Clspn Fbxw11 Stag2 Cenpu Tpx2 Sgo1 Rab1a Rock2 Ppp2r1a Wee1 Prc1 Cdk1 Btrc Ninl Kiz Cdc25c Tpt1 Aurka Cdc25b Ndc80 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Rad50 Fancd2 Pcna Ewsr1 Topbp1 Xrcc6 Brca1 Ube2d3 Xrcc5 Atm Atr Ube2l3 Cdk2 Rbbp8 Ccne1 Cstf1 Bard1 Mre11 Fancl Prkdc Fancc Nbn Tp53 Fancf Fancg Rad51 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway S1pr5 Gnai1 Gnai3 Rhoa Gna12 Gnaz Gnao1 Gnai2 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Nras Shc1 Ngf Src Stat5a Pik3r1 Gab1 Camk4 Ywhah Ywhag Ywhae Grb2 Epb41l1 Pdpk1 Sos1 Camk2a Ywhab Ntrk1 Hras Trpc3 Trpv1 Sfn Egr1 Bad Ccnd1 Plcg1 Gsk3b Prkcd Ywhaz Akt1 Kras Foxo3 Creb1 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Il18r1 Stat3 Pias2 Mapk8 Jun Il2ra Fos Il2 Crebbp Mapk9 Ifng Il13 Cd3g Cd247 Prf1 Cd3d Cd28 Tgfb1 RT1-Da Cd86 Cd80 Tbx21 RT1-Db1 Etv5 Stat4 Irf1 Il18 Cd3e Cd4 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Ncapd2 Septin1 Rasa1 Tacc1 Mylk Des Nsun2 Pebp1 Cul3 Klhl13 Incenp Vim Kif23 Aurkc Aurkb Kif20a Bub1 Rhoa Sgo1 Psma3 Aurka Cenpa Klhl9 Ndc80 Stmn1 Kif2c Ppp2r5d Smc4 Smc2 Ncapg Ncaph Ppp1cc Cbx5 Npm1 Cdca8 Racgap1 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Src Pitpna Pik3r1 Ntn1 Nck1 Dock1 Elmo1 Fyn Yes1 Ptk2 Trio Dcc Map1b Dapk1 Pak1 Unc5b Mapk1 Myo10 Camk2a Map2k2 Unc5a Unc5c Mapk3 Map2k1 Rhoa Bcar1 Rac1 Plcg1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gnai1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Mapk1 Gna13 Mapk3 Rhoa S1pr4 Plcg1 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Mapk1 Map2k1 Pde3b Pik3r6 Pik3cg C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Ppp3ca Kitlg Cbx4 Casp6 Anpep Gata3 Mad1l1 Ca1 Zfhx3 Cdk6 Lect2 Myf6 Tab2 Myod1 Hipk2 Ada Cebpb Sp1 Hras Ccnd1 Hspa8 Crebbp Hes1 Cdkn1a Gata1 Cd4 Cdkn1b Kras Nras Spi1 Ube2i Ets1 Adora2b Ccnb1 Ccna1 Slc25a3 Birc3 Prtn3 Map3k7 Ets2 Clta Tfec Pim1 Tom1 Iqgap1 Cdkn2a Rag2 Ptgs2 Ppidl1 Atp2b1 Snd1 Maf Pias3 Ptcra Kit Smarca2 Mcm4 Cd34 Lef1 Myc Mat2a Trim28 Nlk Cebpa Elane Csf1r Gstm2 Bcl2 Yeats4 Wnt1 Col1a2 H2az1 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Nras Shc1 Rasa1 Rras Src Pxn Pik3r1 Nck1 Rap1a Ephb1 Ephb2 Ephb3 Ptk2 Tf Efnb1 Efnb2 Efnb3 Grb2 Pak1 Rap1b Mapk1 Synj1 Dnm1 Crk Itsn1 Hras Mapk3 Map2k1 Rock1 Kalrn Efna5 Rac1 Kras Grb7 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Src Pik3r1 Mapk8 Pdpk1 Ikbkb Birc2 Ikbkg Map2k7 Map2k6 Birc3 Cltc Syk Cflar Mapk9 Faim2 Bid Pik3cb Map3k1 Casp8 Faslg Rfc1 Casp3 Chuk Ripk1 Btk Fas Mapk14 Fadd Ezr Mapk10 Mapk11 Smpd1 Akt1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Cycs Eif2a Map2k4 Sphk2 Nfkbia Bax Rela Raf1 Egf Mapk8 Igf1 Mapk1 Map2k2 Mapk3 Map2k1 Bad Birc3 Prkcd Bid Map3k1 Casp8 Ripk1 Rb1 Fadd Smpd3 Ctsd Smpd1 Aifm1 Eif2ak2 Tnf Pawr Myc Nsmaf Madd Asah1 Akt1 Tnfrsf1a Bag4 Prkcz Cradd Nfkb1 Bcl2 Pdgfa Traf2 Prkra ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Src Blk Csnk2a1 Pld1 Plcb2 Klk6 Pld2 Th Ube2l3 Tor1a Grk5 Sncaip Fyn Slc6a3 Lyn Yes1 Prkn Uchl1 Maob Fgr Hck Park7 Snca Fkbp1a Bad Syk Prkcd Ptk2b Ppp2r5d Lck ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Syk Src Nfkbia Rela Pik3r1 Mapk14 Btrc Arrb2 Bcl3 Rel Lck Ikbkb Nfkb1 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Map2k4 Itgb1 Pld1 Pld2 Mapk8 Ppp1r12a Jun Rock1 Srf Rhoa Ccn1 Slc9a1 Acta1 Fos Mapk12 Pard6a Map2k6 Diaph1 Slc9a3 Rdx Cfl1 Msn Pten Cit Map2k3 Rock2 Myl2 Limk1 Limk2 Pkn2 Atf2 Pkn1 Sh3gl2 Ezr Tln1 Pip5k1c Pip5k1b F2rl2 Vcl Scai Cdkn1b Prkcz SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Fcgr2a Shc1 Capn1 Spry2 Irs1 Fer Src Lep Egfr Nox4 Lat Lepr Pdgfrb Pdgfb Dok1 Egf Grb2 Crk Socs3 Jak2 Itga2b Blk Stat5a Stat3 Pik3r1 Fyn Lyn Yes1 Fgr Hck Rhoa Bcar1 Stat5b Cav1 Txn1 Ins2 Prl Ybx1 Prlr Cdh2 Akt1 Csn2 Lck Csf1 Csf1r Insr Trpv6 Ptpn1 Csk SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Rasa1 Itgb1 Src Bax Fn1 Kng2l1 Sdc2 Itga2 Cav2 Trappc4 Rack1 Epb41 Lama1 Ephb2 Lama3 Mapk8 Mapk1 Hras Mapk3 Rhoa Fgf19 Cask Prkaca Prkcd Sdcbp Mmp2 Csf2 Casp3 Tgfb1 Ezr Fgf23 Fgfr3 Fgfr4 Nf1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Nras Prkcb Raf1 Ptpn7 Braf Map3k8 Elk1 Prkca Mapk1 Hras Mapk3 Map2k1 Kras Fos ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Brca1 Atf3 Hrk Ccna2 Prkca Serpinb5 Kat5 Macroh2a1 Ddit3 Col24a1 Jdp2 Ruvbl2 Jund Cbfb Csrp2 Ccnd1 Gadd45a Sele Esr1 Dusp5 Tgfb2 Mapk9 Dusp1 Pdgfra Dusp10 Dusp8 Hbg1 Ppargc1a Cdk4 Hes1 Rb1 Socs3 Mapk11 Il6 Nf1 Nos2 Il23a Cul3 Th Mapk8 Mapk1 Jun Arg1 Mapk3 Bcl2l1 Fos Pou2f1 Mmp2 Ifng Plau Junb Atf2 Mapk14 Ins2 Bcl2 Creb1 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Src Blk Fyn Lyn Yes1 Fgr Hck Crk Rock1 Rhoa Efna5 Pik3r6 Pik3cg Vav3 Plcg1 Cbl Efna1 Efna2 Efna3 Arhgef15 Crkl Ngef Epha1 Epha2 Vav2 Epha3 Epha4 Epha6 Epha7 Cdk5 Epha8 Lck SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Max Sap18 Ncor2 Rbbp7 Crebbp Smad7 Yy1 Tnf Gata1 Nr2c1 Hdac3 Prmt5 Tnfrsf1a Hdac7 Nfkb1 Hdac8 Fkbp3 Pparg Chd3 Chd4 Sirt3 Sirt2 Sirt1 Smurf1 Nfkbia Rela Wdr77 Sirt6 Gata2 Sirt5 Sirt4 Stat3 Hdac11 Hdac10 Mta2 Ranbp2 Mbd3 Xpo1 Mbd2 Hdac4 Gatad2a Ube2i Mxd1 Gatad2b Ran Prkaca Btrc Hdac2 Hdac1 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Itga6 Itga9 Itgb1 Pld1 Itga4 Itga1 Pld2 Itga2 Ctnnb1 Klc1 Tshr Cdh1 Agtr1a Slc2a4 Itgav Adrb2 Scamp2 Rala Acap1 Exoc3 Ctnna1 Exoc5 Exoc6 Vamp3 Cltc Nme1 Exoc2 Dnm2 Avpr2 Spag9 Exoc7 Bin1 Ctnnd1 Mapk8ip3 Arf6 Pip5k1c Ins2 Itga10 Itga3 Itga7 Itga8 Itga5 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Sirt1 Xpo1 Ctnnb1 Ywhah Ran Ywhag Ywhae Mapk8 Ywhab Rala Sfn Ikbkb Ccnb1 Gadd45a Plk1 Crebbp Ywhaz Mapk9 Faslg Chuk Cdk2 Csnk1a1 Csnk1g3 Csnk1g1 Bcl2l11 Mapk10 Csnk1g2 Zfand5 Bcl6 Skp2 Fbxo32 Ralb Mst1 Sod2 Usp7 G6pc1 Cdkn1b Rbl2 Akt1 Cat Foxo4 Csnk1d Sgk1 Foxo3 Csnk1e Foxo1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Gna14 Abcc1 Gnaq Sphk2 Sphk1 S1pr1 S1pr3 Gnai1 S1pr2 Sgpp1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Gna13 S1pr4 Gna11 Sgpl1 Gna15 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Src Raf1 Rictor Akt3 Akt2 Casp9 Kpna1 Mapkap1 Gsk3a Mlst8 Ywhah Ywhag Ywhae Pdpk1 Slc2a4 Ywhab Bcl2l1 Sfn Prkaca Bad Gsk3b Ywhaz Mtor Chuk Cdkn1a Hsp90aa1 Cdkn1b Prkdc Akt1 Foxo4 Foxo3 Foxo1 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Afdn Itgb7 Src Pik3r1 Rap1a Tiam1 Enah Ctnnb1 Nckap1 Klhl20 Ap1m1 Cdh1 Wasf2 Rap1b Jup Cttn Crk Tjp1 Dlg1 Rhoa Abi1 Rac1 Ctnna1 Ccnd1 Nme1 Ctnnd1 Iqgap1 Arf6 Pip5k1c Vav2 Akt1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Gli2 Shh Grk2 Tgfb2 Lrpap1 Smo Ptch1 Boc Pthlh Cdon Pik3r1 Arrb2 Akt1 Stil Dhh Hhip Ihh Lrp2 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk4 Plk2 Plk3 Plk1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Nckap1 Wasf2 Crk Abi1 Map2k7 Map2k6 Mapk9 Ncf1 Ncf2 Brk1 Arhgdia Noxa1 Baiap2 Iqgap3 Arpc1b Actr2 Actr3 Arhgap5 Pak2 Wasf1 Arpc3 Noxo1 Arpc2 Cyba Abi2 Cybb Arpc5 Arpc4 Racgap1 Map3k11 Map2k4 Stat5a Plcb2 Stat3 Ctnnb1 Mapk8 Cdh1 Pak1 Jun Bcar1 Rac1 Ctnna1 Cfl1 Map3k1 Map2k3 Iqgap1 Limk1 Atf2 Mapk14 Pip5k1c Pip5k1b VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Gngt2 Gnat2 Rdh12 Slc24a2 Rgs9bp Pde6c Cnga3 Arr3 Cngb3 Grk1 Gucy2e Rpe65 Pde6h Gnb3 Guca1b Gnb5 Guca1a Rgs9 Lrat Gucy2f REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Arhgef7 Mcf2l Arhgef6 Spata13 Fgd1 Itsn1 Arhgef9 Git1 Dnmbp Mcf2 Arhgap17 Dock11 Vav3 Plcg1 Ralbp1 Bcar3 Nme1 Arhgef25 Farp2 Dock6 Arhgap1 Apc Itsn2 Arhgdia Ngef Vav2 Racgap1 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Sirt1 Serpine1 Vegfa Ets1 Elk1 Sp1 Arnt Crebbp Adora2a Flt1 Efna1 Epo Eif3e Twist1 Bhlhe40 Hif1an Egln2 Egln3 Epas1 Cited2 Pgk1 Slc2a1 Vhl Pou5f1 Slc11a2 Mmp14 Apex1 Abcg2 Eloc Fxn REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Trim24 Appbp2 Pde9a Map2k4 Kat7 Sirt1 Src Nr0b1 Spdef Rxrb Rxra Gata2 Smarce1 Ehmt2 Smarcc1 Nr3c1 Rxrg Rack1 Senp1 Tmprss2 Rchy1 Ar Ncoa2 Mdm2 Ncoa1 Mapk8 Kat5 Jun Rel Egr1 Map2k6 Gsk3b Pou2f1 Crebbp Mapk14 Pkn1 Smarca2 Hsp90aa1 Hdac1 Nr2c1 Cebpa Nr2c2 Hdac7 Hoxb13 Carm1 Foxo1 Dnaja1 Zmiz2 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Shc1 Pdgfra Csnk2a1 Pik3r1 Crkl Cav3 Shf Cav1 Elk1 Grb2 Jak1 Sos1 Jun Crk Itgav Srf Fos Plcg1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Src Egfr Fgf23 Fgfr3 Fyn Fgfr4 Ncstn Aph1b Ncan Sdc3 Ptn Mc4r Cttn Psenen Pomc Psen1 Agrp Fgf19 Cask SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Cebpb Jun Ddit3 Atf1 Gdi1 Slc9a1 Eif4ebp1 Pla2g4a Mitf Rab5a Esr1 Elk4 Hspb1 Usf1 Mapkapk3 Krt8 Mef2c Eif4e Mapkapk5 Ppargc1a Rps6ka5 Hbp1 Mknk1 Atf6 Ptgs2 Atf2 Mapk14 Mapk11 Tp53 Creb1 Nos2 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Itgb1 Src Pxn Itga4 Fn1 Dock1 Ptk2 Crk Git1 Abi1 Bcar1 Spp1 Prkaca Rac1 Ywhaz Ptk2b Arf6 Prkar1b Mdk Jaml Tln1 Jam2 Cd81 Ptpra Prkacb Adam28 Myh2 Vcam1 Igsf8 Cd14 Thbs2 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Wnt3a Wnt7a Wnt2 Wnt3 Fzd1 Cthrc1 Fzd2 Kremen2 Fzd5 Fzd4 Ryk Fzd6 Kremen1 Fzd9 Rspo1 Fzd8 Dkk1 Ror2 Atp6ap2 Lrp6 Lrp5 Igfbp4 Wnt5a Wif1 Wnt1 Wnt7b AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Atf3 Nr3c1 Il5 Sp1 Egr1 Jund Cbfb Ccnd1 Esr1 Dusp1 Hif1a Mmp1 Il6 Cdkn1b Ccl12 Gata2 Th Ets1 Dmp1 Ctnnb1 Gja1 Edn1 Elf1 Penk Fosl1 Dmtf1 Jun Mt2 Nts Mafg Ccn1 Bag1 Tcf7l2 Acta1 Fos Cops5 Fabp4 Il2 Timp1 Il4 Agt Nppa Ifng Mmp9 Pten Plau Csf2 Junb Nfatc3 Cdkn2a Nfatc2 Tgfb1 Cdk1 Atf2 Il10 Bcl2l11 Maf Myc Tp53 Creb1 Col1a2 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Sdcbp Csf2rb Il5ra Cish Stat5a Pim1 Ptpn11 Pik3r1 Stat5b Lyn Il5 Grb2 Jak2 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Pxn Rictor Xpo1 Ctnnb1 Arhgef7 Arhgef6 Ppp1r12a Ilk Jun Ruvbl2 Rac1 Ccnd1 Diaph1 Gsk3b Ilkap Ruvbl1 Rhog Ppp1r14a Parp1 Ppp1r14c Iqgap1 Ppp1r14b Naca Elmo2 Nck2 Tns1 Git2 Parvg Tacc3 Aurka Snai1 Lims2 Zeb1 Actn1 Hsp90aa1 Parvb Zyx Cdc37 Akt1 Parva Ckap5 Myl9 Creb1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Gap43 Kif5b Cnr1 Fgfr1 Fer Gria2 Dagla Axin1 Ptpn11 Pik3r1 Ctnnb1 Gja1 Mapk8 Jup Cttn Rock1 Rhoa Rac1 Ctnna1 Plcg1 Gsn Ctnnd1 Myl2 Pip5k1c Cdh2 Lrp5 Daglb Camk2g Mapre1 Ptpn1 Dctn1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Rxrb Fam120b Rxra Rara Med1 Rarg Thrb Rxrg Thra Nr1h4 Nr1h3 Nr1h2 Ppard Ppara Ncoa1 Abca1 Srebf1 Nr4a1 Ncor2 Vdr Rps6kb1 Tgfb1 Tnf Bcl2 Pparg P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Tp63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Lmo4 Pcna Nr0b1 Brca1 Med1 Cebpb Ncoa2 Ncoa1 Col18a1 Mpg Nrip1 Sra1 Ube2m Apbb1 Ebag9 Safb Phb2 Ncor2 Ccnd1 Pdia2 Anp32a Esr1 Ap1b1 Pou4f1 Lcor Pou4f2 Nr0b2 Cd82 Smad4 Dscam Pgr Axin2 Tff1 Setsip Ncoa7 Atp5pf C3 Mta1 Hsf2 Xbp1 Sod1 Ctsd Esr2 Ndufv3 Abca3 Prdm15 Calcoco1 Uba3 Nedd8 Stat5a Hdac4 Jun Chuk Prl Myc Hdac1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Angpt1 Shc1 Rasa1 Pxn Fn1 Ptpn11 Nck1 Ptk2 Elk1 Nos3 Grb2 Crk Tek Cdkn1a Tnf Grb14 Fgf2 Nfkb1 Angpt2 Angpt4 F2 Elf2 Itga5 Tnip2 Plg Bmx Itgb1 Rela Stat5a Pld2 Pik3r1 Fyn Ets1 Mapk8 Elf1 Pak1 Mapk1 Agtr1a Mapk3 Dok2 Rac1 Mmp2 Rps6kb1 Mapk14 Stat5b Fes Akt1 Foxo1 Grb7 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Nras Prkcb Tnfrsf4 Prkce Ifnar1 Eomes Egr4 Prkcq Raf1 Tnfrsf9 Cd8b Cd8a Ifna1l1 B2m Ptpn7 Braf Elk1 Mapk8 Prkca Mapk1 Fosl1 Jun Map2k2 Hras Mapk3 Map2k1 Il2ra Egr1 Fos Il2 Mapk9 Ifng Cd3g Cd247 Faslg Prf1 Cd3d Junb Nfatc3 Nfatc2 Il2rg Stat4 Cd3e Tnf Kras SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Rasa1 Src Pxn Raf1 Nck1 Rap1a Ptk2 Braf Arhgap35 Grb2 Rap1b Sos1 Crk Map2k1 Ccnd1 Plcg1 Mapk9 Itga5 Rras Bmx Map2k4 Itgb1 Pik3r1 Arhgef11 Dock1 Asap1 Elmo1 Arhgef28 Fyn Arhgap26 Yes1 Ets1 Capn2 Ptpn21 Arhgef7 Mapk8 Pak1 Mapk1 Jun Itgav Rhoa Bcar1 Rac1 Acta1 Rock2 Mapk8ip3 Nck2 Tln1 Git2 Vcl Actn1 Grb7 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Lama5 Itga6 Lamb2 Lamb3 Lama2 Itgb4 Lamb1 Lamc1 Lama1 Lama3 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Rad50 Fancd2 Topbp1 Brca1 Atm Atr H2ax Ube2t Blm Chek1 Wdr48 Usp1 Fancb Palb2 Rfc5 Rfc3 Faap100 Rfc4 Fbxw11 Rfc2 Rmi1 Hus1 Rpa2 Rad17 Atrip Hes1 Brip1 Brca2 Rad1 Faap24 Btrc Fan1 Mre11 Fancl Fancc Nbn Fancf Fancg VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Adrm1 Il1a Axl Perp Top2a Atm Rack1 Ada Mdm2 Tp63 Runx1 Sfn Vdr Gsk3b Hes1 Hbp1 Cdkn2a Brca2 Col5a1 Dlx5 Dlx6 Bdkrb2 Ppp2r5a Igfbp3 Hells Notch1 Sec14l2 Itch Stxbp4 Mre11 Tcf7l1 Ccnb2 Gpx2 Itga3 Rrad Krt14 Wwp1 Rab38 Nrg1 Tbxt CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Casp6 App Arhgdib Slk Cfl2 Xiap Sptan1 Lmna Casp9 Apaf1 Gas2 Top1 Tfap2a Numa1 Ptk2 Lmnb1 Lmnb2 Pidd1 Srebf1 Casp7 Krt18 Casp4 Satb1 Casp2 Casp1 Diablo Dffa Dffb Birc2 Bid Casp8 Prf1 Parp1 Casp3 Ripk1 Tnf Madd Tnfrsf1a Cradd Traf2 Cycs Bax Vim Acta1 Gsn Birc3 Map3k1 Limk1 Bcl2 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Dock1 Elmo1 Tiam1 Trio Arhgef7 Arhgef6 Sos1 Spata13 Abi1 Kalrn Mcf2 Arhgef2 Rac1 Arhgap17 Dock2 Abr Vav3 Ralbp1 Eps8 Rap1gds1 Arhgef25 Prex1 Prex2 Dock6 Vav1 Arhgap1 Bcr Arhgap9 Arhgdia Ngef Vav2 Racgap1 Rasgrf2 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Plg Itgam Itgb2 Rap1a Rap1b Hck Rock1 Rhoa Thy1 Mmp2 Mmp9 Selp Plau Lrp1 Selplg Ccn2 Jam3 Plat Ager Icam1 Tln1 Mst1r Jam2 Apob Mst1 Myh2 Tnf Il6 Nfkb1 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Nme1 Pld1 Pld2 Arf6 Tiam1 Arf1 Rab11fip3 Rab11a Mapk1 Mapk3 Rhoa Kalrn Rac1 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Shc1 Rasa1 Sphk1 Fer S1pr1 Pxn Lat Raf1 Ptpn11 Ptk2 Dok1 Grb2 Sos1 Map2k2 Hras Map2k1 Ikbkb Ikbkg Pla2g4a Plcg1 Map2k7 Dusp1 Vav1 Btk Itk Fcer1a Plpp1 Pak2 Klrg1 Hcls1 Cblb Wipf1 Lat2 Lcp2 Nfkb1 Ptpn13 Pla2g1b Ms4a2 Fcgr2b Prkcb Map2k4 Rela Pld2 Pik3r1 Fyn Lyn Mapk8 Mapk1 Jun Mapk3 Fos Inpp5d Syk Cbl Map3k1 Chuk Nfatc2 Akt1 Gab2 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Gna14 Cxcr4 Gnaq Src S1pr3 Gnai1 Gnai3 Akt3 Gna12 Pdgfrb Gnaz Gnao1 Vegfa Gnai2 Pdgfb Mapk1 Gna13 Mapk3 Rhoa Rac1 Flt1 Akt1 Gna11 Jak2 Gna15 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Itgb7 Ptk2 Madcam1 Itgb1 Vcam1 Pxn Itga4 Rhoa NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Shc1 Rasa1 Ngf Frs3 Ptpn11 Ntf4 Ntf3 Rap1a Gab1 Frs2 Tiam1 Grb2 Rap1b Sos1 Ntrk2 Dnm1 Crk Ntrk1 Hras Map2k1 Ntrk3 Ccnd1 Plcg1 Crkl Kras Prkcz Nras Matk Sqstm1 Faim Prkci Maged1 Dnaja3 Ngfr Shc3 Stat3 Shc2 Pik3r1 Gipc1 Rgs19 Dock1 Dynlt1 Elmo1 Nedd4l Abl1 Arhgap32 Rit1 Rit2 Ehd4 Mcf2l Mapk1 Mapk3 Rhoa Rac1 Rhog Gab2 Bdnf CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Nras Src Blk Lat Pik3r1 Rap1a Fyn Lyn Yes1 Cyth2 Fgr Zap70 Hck Cyth3 Pdpk1 Cyth1 Dapp1 Hras Inppl1 Rhoa Plekha1 Plcg2 Blnk Pik3r6 Pik3cg Rac1 Adap1 Arf5 Plcg1 Inpp5d Syk Pik3cb Pten Btk Arf6 Arf1 Itk Hsp90aa1 Kras Lck Sgk1 Foxo3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Shc1 Stat5a Tab2 Pik3r1 Fyn Mdm2 Grb2 Mapk1 Mapk3 Wwox Erbb2 Erbb4 Nedd4 Lrig1 Adam17 Ereg Pik3cb Hbegf Nrg2 Btc Cbfa2t3 Nrg4 Nrg3 Dlg4 Grin2b Stat5b Itch Prl Prlr Wwp1 Jak2 Nrg1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Nras Shc1 Stat5a Raf1 Stat3 Ptpn11 Stat1 Pik3r1 Lyn Grb2 Mapk1 Sos1 Map2k2 Hras Mapk3 Map2k1 Ikbkb Prkaca Fos Inpp5d Syk Csf2rb Ywhaz Cish Pim1 Csf2 Osm Stat5b Irf8 Prkacb Ccl12 Gab2 Kras Jak2 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Mapk13 Map2k6 Eef2k Snta1 Stmn1 Map2k3 Pkn1 Mapk12 Ccnd1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Afdn Egfr Nck1 Enah Ctnnb1 Nckap1 Egf Cdh1 Igf1 Rock1 Rhoa Git1 Abi1 Exoc3 Igf1r Ctnna1 Diaph1 Ctnnd1 Myl2 Efna1 Arf6 Hgf Pip5k1c Epha2 Vcl Lima1 Met Vasp Aqp5 Actn1 Kifc3 Mgat3 Zyx Aqp3 Lpp Nectin2 Myo6 Stx4 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Camkk2 Akap1 Sh2d2a Hsp90ab1 Hgs Src Pxn Ptpn2 Vtn Grb10 Raf1 Ptpn11 Nck1 Gab1 Vegfa Ptk2 Braf Nos3 Grb2 Prkca Pdpk1 Map2k2 Map2k1 Rock1 Plcg1 Map2k6 Prkcd Mapk11 Arf1 Pak2 Prkcb Pik3r1 Fyn Ctnnb1 Mapk1 Itgav Mapk3 Rhoa Prkaca Ctnna1 Ptpn6 Nedd4 Fbxw11 Dnm2 Cbl Ptk2b Map2k3 Flt1 Iqgap1 Mapk14 Nck2 Cav1 Fes Vcl Hsp90aa1 Akt1 Myof Cdh5 Ptprj VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Riox2 Eno1 Bmi1 Ndufaf2 Bcat1 Ddx18 Shmt1 Max Hspd1 Prdx3 Cad Nme2 Mtdh Actl6a Cdc25a Serpini1 Odc1 Kat5 Taf9 Eif4g1 Gpam Rpl11 Id2 Ruvbl2 Eif2s1 Kat2a Supt7l Pfkm Lin28b Myct1 Ccnd2 Tfrc Crebbp Pdcd10 Smad3 Hspa4 Ireb2 Eif4e Smad4 Eif4a1 Ubtf Cdk4 E2f3 Mta1 Npm1 Bax Fosl1 Ccnb1 Nme1 Mmp9 Ruvbl1 Pim1 Slc2a1 Snai1 Hmga1 Hsp90aa1 Myc Tert Nbn Tp53 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Map2k4 Src Blk Fyn Lyn Yes1 Fgr Pak1 Hck Rala Rac1 Map2k6 Dusp1 Dusp10 Dusp8 Map2k3 Dusp16 Ripk1 Traf6 Pak3 Mapk14 Map3k3 Map3k12 Mapk11 Ralb Pak2 Lck SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Shc1 Kitlg Fer Grb10 Raf1 Ptpn11 Gab1 Dok1 Grb2 Pdpk1 Sos1 Map2k2 Hras Map2k1 Bad Mitf Gsk3b Crebbp Vav1 Crkl Stap1 Ptpro Spred1 Spred2 Epor Grap2 Pik3c2b Sh2b2 Map4k1 Tec Jak2 Matk Stat5a Stat3 Stat1 Pik3r1 Socs1 Lyn Mapk8 Mapk3 Ptpn6 Cbl Pten Rps6kb1 Epo Kit Akt1 Foxo3 Bcl2 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Shh Mapk9 Mapk8 Ptch1 Bmp4 Fgf7 Gpc3 Furin ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Adam8 Sat1 Itga9 Kcnj15 Itgb1 Vegfd Src Vegfc Pxn Paox Tgm2 Csf2 Fn1 Vegfa Vcam1 Bcar1 Adam2 Spp1 Adam12 Rac1 F13a1 Nos2 Adam15 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Xrcc6 Pnkp Polm Xrcc5 Nhej1 Dntt Dclre1c Aptx Lig4 Aplf Xrcc4 Poll Prkdc SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Shc1 Hgs Src Pxn Ptpn2 Raf1 Akt2 Ptpn11 Nck1 Rap1a Gab1 Mlst8 Ptk2 Grb2 Rap1b Pdpk1 Sos1 Crk Map2k2 Hras Map2k1 Egr1 Eif4ebp1 Bad Plcg1 Rab5a Eif4e Hgf Crkl Met Pak2 Prkcz Map2k4 Prkci Pik3r1 Rptor Ets1 Ctnnb1 Kpnb1 Numb Sh3kbp1 Mapk8 Cdh1 Eps15 Pak1 Mapk1 Rin2 Arhgef4 Jun Pak4 Mapk3 Inppl1 Akt1s1 Rhoa Muc20 Bcar1 Ranbp10 Rac1 Ctnna1 Pard6a Inpp5d Cbl Map3k1 Mtor Apc Arf6 Nck2 Sh3gl2 F2rl2 Snai1 Akt1 Gab2 Ptpn1 Ptprj EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Nras Shc1 Rasa1 Src Egfr Gnai1 Gnai3 Stat3 Ptpn11 Stat1 Pik3r1 Nck1 Gab1 Ptk2 Egf Grb2 Pak1 Mapk1 Sos1 Hras Mapk3 Plcg1 Gsn Ptpn6 Pik3cb Nck2 Tln1 Pip5k1c Kras Ptpn1 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Gna14 Prkcb Gnaq Gnai1 Plcb2 Gnai3 Pik3r1 Gna12 Gnaz Gnao1 Gnai2 Nos3 Prkca Dnm1 Gna13 Rock1 Rhoa Plcb3 F2r Arhgef1 Plcb1 Trpc6 Grk3 Prkcd Snx2 Snx1 Dnm2 Arrb1 Prkcg Gnb1 Rock2 Myl2 Pkn1 Arhgdia F2rl2 Vasp Zyx Gna11 F2 Gna15 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Cxcr4 Plg Fgfr1 Itgb1 Fn1 Gipc1 Lama1 Lama3 Ptk2 Prkca Rhoa Ccl5 Rac1 Prkcd Sdcbp Dnm2 Mmp9 Cxcl12 Sdc4 Fgf6 Nudt16l1 Tfpi Mdk Actn1 Fgf2 Adam12 F2 Itga5 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Atm Atr Hipk2 Rchy1 Ccna2 Kat5 Rpl11 Gsk3b Prkcd Crebbp Mapk9 Cdk2 Yy1 Nedd8 Prmt5 Abl1 Mdm2 Mapk8 Chek1 Ppp2ca Cdkn2a Csnk1a1 Smyd2 Csnk1g3 Mapk14 Csnk1g1 Cse1l Kat8 Csnk1g2 Fbxo11 Kmt5a Skp2 Dyrk2 Ptpa Rpl23 Ube2d1 Rassf1 Usp7 Ccng1 Trim28 Chek2 Setd7 Akt1 Rpl5l1 Csnk1d Ttc5 Pin1 Tp53 Csnk1e Mdm4 E4f1 Ppm1d Daxx CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Rnf128 Ctla4 Dgka Slc3a2 Egr3 Gata3 Foxp3 Egr4 Prkcq Il5 Fosl1 Jun Il2ra Egr1 Irf4 Fos Batf3 Il2 Il4 Pou2f1 Ifng Cd40lg Faslg Csf2 Casp3 Cdk4 Junb Nfatc3 Nfatc2 Egr2 Ptgs2 Tbx21 Maf Tnf Itch Cblb E2f1 Ptpn1 Pparg E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Ctnnb1 Cdh1 Jup S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Gna14 Gnaq Irs1 Gnai1 S1pr2 Gnai3 Gna12 Mapk14 Gnaz Gnao1 Gnai2 Elk1 Mapk8 Pak1 Mapk1 Jun Gna13 Mapk3 Rhoa Gna11 Fos Rac1 Cdh5 Gna15 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Src Gnrh1 Gnai1 Shbg Raf1 Plcb2 Pelp1 Gnai3 Pik3r1 Gnaz Gnao1 Gnai2 Ar Ptk2 Mapk1 Map2k2 Hras Mapk3 Map2k1 Plcg2 Plcb3 Rac1 Fos Plcb1 Plcg1 Gnb1 Akt1 Creb1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Ccne1 Chek2 Plk3 Tp53 Cdc25c VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Itgb4 Hmox1 Txlng Usf2 Lif Dcn Thbd Lama3 Mgp Atf4 Gja1 Nos3 Sp1 Ccna2 Fosl1 Dmtf1 Jun Jund Ccnd1 Bglap Mmp2 Mmp9 Plau Junb Nfatc3 Mmp1 Cdkn2a Nfatc2 Il6 Ccl12 Col1a2 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Rad50 Fancd2 Brca1 Atm Dclre1c Abl1 Xrcc4 Terf2 Mdm2 Tp53bp1 ABRAXAS1 Smc3 Cdc25a Ube2n Uimc1 H2ax Kat5 Smc1a Ywhab Blm Bid Rad17 Cdc25c Rbbp8 Ctbp1 Trim28 Chek2 Mre11 Nbn HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Cycs Casp6 Nfkbia Rela Casp9 Apaf1 Casp7 Mapk8 Casp2 Map2k7 Birc3 Cflar Bid Cd247 Casp8 Faslg Casp3 Chuk Ripk1 Map3k14 Fas Fadd Tnf Tnfrsf1a Bag4 Cradd Nfkb1 Bcl2 Traf2 Daxx ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling S100a9 Tirap Tlr4 S100a8 Tlr3 Tlr2 Chuk Hspd1 Cd14 Irak2 Irak1 Bgn Rhoa Sftpa1 Ikbkb Myd88 Vcan Ikbkg Irak4 Tlr6 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Il17a Ifng Gata3 Il12rb2 Stat5a Ebi3 Il27 Il1b Il6st Il12a Stat3 Tgfb1 Stat2 Stat1 Tbx21 Stat4 Il18 Il12b Jak1 Tnf Il6 Jak2 Il2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Shc1 Ngf Casp6 App Xiap Ntf4 Casp9 Apaf1 Ntf3 Ncstn Aph1b Ywhae Psenen Ntrk1 Psen1 Irak1 Diablo Ikbkb Myd88 Birc2 Bad Ikbkg Mapk9 Mmp7 Casp3 Traf6 Zfp110 Rhoc Arhgdia Rhob Lingo1 Mapk10 Mmp3 Omg Mag Prkacb Mageh1 Smpd2 Bex3 Bex1 Nsmce3 Rtn4 Ripk2 Ndn Prdm4 Furin Prkcz Sort1 Cycs Plg Sqstm1 Prkci Maged1 Ngfr Pik3r1 Mapk8 Rhoa Rac1 Birc3 Adam17 Chuk Bcl2l11 Akt1 Tp53 E2f1 Bdnf CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Gsk3b Wnt3a Dvl3 Pi4k2a Apc Axin1 Cul3 Fzd5 Csnk1g1 Gsk3a Pip5k1b Cav1 Ppp2r5a Ctnnb1 Lrp6 Nkd2 Ranbp3 Dvl1 Klhl12 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Shc1 Il17rd Spry2 Ncam1 Fgfr1 Src Ssh1 Fgfr2 Rps6ka1 Sdc2 Ptpn11 Stat1 Pik3r1 Gab1 Frs2 Grb2 Cdh1 Mapk1 Pdpk1 Sos1 Camk2a Jun Cttn Pak4 Mapk3 Fgf19 Runx2 Spp1 Fos Bglap Plcg1 Cbl Ptk2b Mmp9 Plau Ctnnd1 Fgf23 Fgfr3 Stat5b Fgfr4 Cdh2 Akt1 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Bmpr2 Smad1 Acvr1 Smad4 Tlx2 Smad9 Amhr2 Amh Bmp7 Fkbp1a Smad5 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Xrcc6 Brca1 Pelp1 Cdk6 Xrcc5 Med1 Tmprss2 Ar Ncoa2 Nrip1 Ccnd1 Casp8 Kdm1a Pawr Uba3 Hip1 Lats2 Fhl2 Kdm4c Zfp318 Prdx1 Ube2i Fkbp4 Rps6ka3 Ctnnb1 Mak Pias1 Pa2g4 Ube3a Svil Tmf1 Ctdsp1 Nkx3-1 Zmiz1 Srf Snurf Ncoa4 Ncoa6 Ccnd3 Kdm3a Vav3 Tgfb1i1 Gsn Tcf4 Ptk2b Cdkn2a Pias3 Tgif1 Pias4 Akt1 Prkdc Carm1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Casr Fmn1 Ajuba Src Egfr Ctnnd1 Akt2 Pik3r1 Fyn Ctnnb1 Vasp Cdh1 Jup Zyx Akt1 Rhoa Ctnna1 Rac1 Plcg1 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Lmo4 Map2k4 Il6st Stat3 Ptpn11 Stat1 Pik3r1 Gab1 Cebpb Il6r Pias1 Jak1 Grb2 Hck Sos1 Jun Bcl2l1 Rac1 Fos Mitf Timp1 Map2k6 Prkcd Crp Vav1 Hsp90b1 Lbp Mcl1 Ptpre Junb Fgg Tnfsf11 A2m Mapk14 Socs3 Mapk11 Pias3 Irf1 Il6 Myc Akt1 Gab2 Jak2 Foxo1 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha2 Epha3 Epha4 Epha6 Epha7 Epha8 Efna5 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Fancd2 Topbp1 Atr Mdm2 Cdc25a Ccna2 Ywhab Chek1 Ppp2ca Rfc5 Plk1 Rfc3 Clspn Rfc4 Fbxw11 Ywhaz Rfc2 Hus1 Rpa2 Rad17 Atrip Ppp2r1a Cdk2 Brca2 Rad1 Mcm7 Btrc Smarcal1 Ppp2r2b Timeless Cdc25c Cep164 Cdc6 Tipin Mcm2 Nbn Rad51 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Gsk3b Wnt3a Dvl3 Apc Axin1 Fzd5 Axin2 Csnk1a1 Btrc Gsk3a Ctnnb1 Cul1 Skp1 Lrp6 Csnk1d Csnk1e Dvl1 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Shc1 Irs1 Pxn Irs2 Grb10 Raf1 Ptpn11 Pik3r1 Rack1 Ptk2 Ywhae Grb2 Igf1 Pdpk1 Sos1 Crk Hras Bcar1 Igf1r Bad Prkcd Ywhaz Rps6kb1 Crkl Nck2 Prkd1 Akt1 Prkcz Ptpn1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Map2k6 Map2k4 Map2k3 Il1b Pgr Il18 Tnf Vcam1 Mapk1 Map2k2 Antxr1 Casp1 Mapk3 Map2k1 Map2k7 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Sag Rdh12 Rgs9bp Gnb1 Grk1 Gucy2e Rpe65 Guca1b Gnb5 Guca1a Rgs9 Lrat Gucy2f Gngt1 Slc24a1 Cngb1 Pde6a Pde6b Gnat1 Cnga1 Rho FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Onecut1 Foxm1 Cks1b Tgfa Lama4 Xrcc1 Cenpf Aurkb Gsk3a Sp1 Ccna2 Map2k1 Fos Ccnb1 Ccnd1 Plk1 Esr1 Mmp2 Crebbp Cdk4 Nfatc3 Cdk2 Cdkn2a Brca2 Cdk1 Rb1 Etv5 Skp2 Cenpa Cdc25b Ccne1 Myc Chek2 Ccnb2 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Gna14 Prkcb Prkce Pld1 Cxcr1 Plcb2 Gnai2 Lyn Fgr Hck Prkca Pdpk1 Dnm1 Plcb3 Pik3r6 Pik3cg Plcb1 Rab5a Grk2 Cbl Arrb1 Prkcg Gnb1 Arrb2 Akt1 Gna15 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Fcgr2a Itgam Kng2l1 Spon2 Itgb2 Proc Gp1ba Itgal Fgb Fga F10 F11r Icam2 Ccn1 Thy1 Cd40lg Plau Fgg Jam3 Plat Icam1 C3 Vcam1 Itgad Itgax INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Gsk3b Ywhaz Prkci Akt2 Asip Trip10 Ywhah Ppp1r3a Ywhag Vamp2 Ywhae Ins2 Gys1 Stxbp4 Lnpep Slc2a4 Rhoq Ywhab Akt1 Ppp1cc Sfn Prkcz Insr Stx4 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Afdn Sphk1 S1pr1 Ptpn2 Raf1 Pdgfrb Pdgfb Nckap1 Arhgap35 Rap1b Wasf2 Cttn Map2k2 Sla Arap1 Map2k1 Rab4a Abi1 Usp6nl Tagln Myocd Actn4 Map2k7 Nherf2 Nherf1 Sipa1 Pik3cb Brk1 Arhgdia Mapk10 Baiap2 Arpc1b Actr2 Actr3 Eif2ak2 Arpc3 Arpc2 Arpc5 Jak2 Arpc4 Map2k4 Blk Stat5a Stat3 Stat1 Pik3r1 Lyn Fgr Mapk8 Hck Pak1 Mapk1 Itgav Mapk3 Rhoa Srf Bcar1 Ppp2ca Rac1 Pten Ppp2r1a Pin1 Ptpn1 Csk Shc1 Rasa1 Src Grb10 Ptpn11 Nck1 Rap1a Gab1 Dok1 Braf Ywhah Elk1 Ywhag Grb2 Ywhae Prkca Sos1 Crk Ywhab Hras Sfn Jund Pla2g4a Plcg1 Eps8 Rab5a Prkcd Ywhaz Mapk9 Lrp1 Vav2 Kras Nras Prkce Abl1 Fyn Yes1 Rps6ka3 Jun Pik3r6 Pik3cg Fos Dnm2 Cbl Iqgap1 Nck2 Ppp2r2b Stat5b Myc Lck Ptprj ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Fkbp1a Acvrl1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Afdn Src Pik3r1 Pdgfrb Rap1a F11r Pdgfb Ptk2 Ctnnb1 Cdh1 Rap1b Crk Itgav Rac1 Ctnna1 Nectin1 Farp2 Nectin3 Ptprm Cldn1 Iqgap1 Tln1 Pip5k1c Vav2 Nectin2 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Ppp3ca Shc1 Rasa1 Raf1 Dok1 Elk1 Grb2 Pdpk1 Sos1 Hras Map2k1 Ikbkb Ikbkg Cd72 Cd22 Malt1 Cd79b Traf6 Btk Bcl2a1 Bcl10 Ptprc Nfkbib Ppp3cc Ppp3cb Sh3bp5 Vav2 Map4k1 Nfkb1 Fcgr2b Nfkbia Rela Csnk2a1 Pik3r1 Lyn Ets1 Mapk8 Mapk1 Jun Dapp1 Mapk3 Plcg2 Blnk Rac1 Fos Inpp5d Syk Ptpn6 Map3k7 Map3k1 Pten Chuk Mapk14 Akt1 Camk2g Csk REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Arhgdib Arhgef11 Arhgef28 Trio Arhgap35 Mcf2l Ect2 Arap1 Rhoa Mcf2 Arhgef2 Arhgef1 Abr Vav3 Arhgef25 Vav1 Bcr Arhgap9 Arhgef15 Arhgdia Ngef Srgap1 Vav2 Arhgef5 Arhgef3 Ophn1 Arhgap5 Arhgdig Arhgef12 Arhgef18 Cdkn1b Farp1 Net1 Arhgap4 Arhgap8 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Syt1 Rab3gap2 Stx1a Vamp2 Stxbp1 Unc13b Chrna1 Snap25 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Gata3 Eno1 Ncstn Aph1b Dnm1 Psenen Ncor2 Ccnd1 Maml1 Maml2 Cdkn1a Kdm1a Rbbp8 Rab11a Yy1 Notch1 Furin Adam12 Mark2 Adam10 Neurl1 Notch4 Notch2 Notch3 Dll1 Dll3 Dll4 Mfap5 Jag2 Jag1 Mfap2 Dlk1 Mib1 Cntn1 Numb Cntn6 Dner Eps15 Lnx1 Il4 Cbl Btrc Ptcra Skp2 Cul1 Ctbp1 Skp1 Itch Myc Hdac1 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Shc1 Foxp3 Stat5a Cdk6 Ptpn11 Pik3r1 Jak3 Sp1 Jak1 Grb2 Ccna2 Elf1 Sos1 Bcl2l1 Il2ra Ccnd3 Il2 Lta Il4 Ccnd2 Faslg Prf1 Il2rg Stat5b Myc Gab2 Lck Bcl2 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Nras Shc1 Src Raf1 Stat3 Ptpn11 Pik3r1 Grb2 Mapk8 Mapk1 Sos1 Erbb3 Jun Map2k2 Nfatc4 Hras Mapk3 Nf2 Map2k1 Chrne Usp8 Prkaca Rnf41 Rac1 Bad Fos Erbb2 Mapk9 Mtor Pik3cb Nrg2 Mapk10 Ppp3cb Akt1 Kras Jak2 Nrg1 Chrna1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Gna14 Prkcb Plcb2 Pld2 Elmo1 Gnai2 Lyn Fgr Hck Prkca Pdpk1 Dnm1 Plcb3 Ppp2ca Pik3r6 Cxcr2 Pik3cg Rab7a Dock2 Plcb1 Rac2 Rab5a Cbl Arrb1 Prkcg Gnb1 Ppp2r1a Arrb2 Rab11a Vasp Akt1 Gna15 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc1 Sdc3 Sdc4 Sdc2 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Sphk1 Itga2b Lama4 Vtn Fn1 Fgb Pdgfrb Fga Vegfa F11r Pdgfb Lamb1 Itgav Ccn1 Spp1 Thy1 L1cam Cd47 Col1a1 Ibsp Col4a3 Plau Fbn1 Sdc4 Fgg Col4a1 Lamc1 Col4a5 Sdc1 Tgfbr2 Col1a2 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Shc1 Rasa1 Irs1 Irs2 Raf1 Ptpn11 Grb2 Sos1 Map2k2 Hras Map2k1 Mapk9 Cdk2 Socs3 Mapk11 Kras Nras Prkcb Prkce Stat5a Stat3 Stat1 Pik3r1 Socs1 Fyn Jak3 Jak1 Mapk8 Mapk1 Jun Mapk3 Rhoa Il2ra Dok2 Fos Il2 Syk Ifng Ptk2b Cish Socs2 Stam2 Ikzf3 Stam Mapk14 Il2rg Stat5b Myc Gab2 Lck Bcl2 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc2 Gpc3 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Atr Npas2 Bhlhe40 Nr1d1 Nono Cry1 Cry2 Timeless Clock Bmal1 Per2 Per1 Wdr5 Chek1 Csnk1e IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Map2k6 Cd3g Cd247 Il12rb2 Cd3d Il12a RT1-Da Tbx21 RT1-Db1 Stat4 Il18 Il12b Cd3e Cd4 Ripk2 Nfkb1 Jak2 Nos2 Sphk2 Rela Eomes Stat5a Il18r1 Il1b Cd8b Stat3 Cd8a Stat1 Socs1 B2m Stat6 Il2ra Fos Rab7a Il2 Il4 Ifng Mtor Faslg Map2k3 Atf2 Mapk14 Il2rg Nfkb2 Ccr5 Gadd45g Gzma Gadd45b Hlx Lck Ccl4 Il1r1 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Itgb7 Madcam1 Vtn Plau Fbn1 Itga4 Fn1 Sdc1 Vcam1 Itgav Itgb8 Ccn1 Tgfbr1 Itgb6 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Pik3c2a Irs1 Src Pxn Vtn Fn1 Ptpn11 Vegfa F11r Ptk2 Igf1 Col11a1 Rock1 Col11a2 Igf1r Col2a1 Col3a1 Col1a1 Casp8 Col4a3 Col5a2 Col6a2 Col4a1 Col5a1 Col4a5 Sdc1 Cdkn1b Fgf2 Pik3r1 Mapk1 Ilk Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Vav3 Cbl Ptk2b Rps6kb1 Tln1 Vcl Hsp90aa1 Akt1 Csf1 Csf1r Angptl3 Tgfbr2 Mfge8 Col1a2 Pi4kb SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Tubb2a Sirt3 Mef2d Crebbp Sirt2 Acss1 Sirt1 Acss2 Bax Xrcc6 Ppargc1a Myod1 Fhl2 Cdkn1a Hdac4 Foxo4 Foxo3 Tp53 Foxo1 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Mnat1 Ccnh Rxrb Rxra Cdk7 Rara Rbp1 Rarg Rxrg Ncoa2 Ncoa1 Mapk8 Prkca Mapk1 Nrip1 Mapk3 Prkaca Ncor2 Vdr Crebbp Prkcg Cdk1 Mapk14 Hdac1 Hdac3 Akt1 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Arnt Hif1a Rbx1 Hif3a Cdkn2a Os9 Hif1an Rack1 Naa10 Egln2 Cul2 Egln3 Vhl Hsp90aa1 Eloc Tp53 Cops5 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Vtn Brca1 Pisd Cebpb Sftpd Ar Nfib Nfia Nfic Scgb1a1 Sp1 Nr2f2 Gcg Col18a1 C4bpb Jun Serpina1 Nrip1 Nkx3-1 Sftpa1 Fos Foxa1 Esr1 Shh Ap1b1 Foxa2 Pou2f1 Foxa3 Crebbp Dscam Tff1 Atp5pf Apob Xbp1 Sod1 Ndufv3 Ins2 Prdm15 Cdkn1b NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Dvl3 Cthrc1 Fzd2 Fzd5 Fzd6 Tab2 Yes1 Ror2 Mapk8 Camk2a Daam1 Flna Rock1 Rhoa Chd7 Rac1 Mapk9 Map3k7 Nfatc2 Csnk1a1 Arrb2 Mapk10 Nlk Prkcz Wnt5a Dvl1 Pparg PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Gna14 Nras Shc1 Gnaq Src Gnai1 Plcb2 Pelp1 Gnai3 Pik3r1 Gnaz Gnao1 Gnai2 Nos3 Grb2 Igf1 Sos1 Hras Gna13 Rhoa Bcar1 Gnal Plcb3 Strn Igf1r Plcb1 Esr1 Mmp2 Msn Mmp9 Hbegf Gnb1 Rock2 Mapk11 Esr2 Akt1 Kras Gna11 Gna15 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Ar Camk4 Ncoa2 Ywhah Ywhag Ywhae Ywhab Id2 Sfn Ruvbl2 Cacna1g Vcan Myog Ccnd1 Neurog1 Mitf Mdfic Igf2bp1 Ccnd2 Cby1 Ywhaz Fgf4 Zcchc12 Tbl1xr1 Kcnip4 Tnik Adcy7 Mt-co2 Axin2 Hbp1 Tle4 Med12 Tle2 Krt1 Tle1 Tle5 Dkk4 Chd8 Smarca4 Tcf7 Tbl1x Sp5 Cdx4 Cdx1 Ctnnbip1 Klf4 Pitx2 Myf5 Dvl3 Incenp Xpo1 Dkk1 Ctnnb1 Cdh1 Jun Ccn1 Tcf7l2 Tcf4 Mmp2 Mmp9 Apc Cdkn2a Btrc Hdac2 Cul1 Ctbp1 Skp1 Lef1 Myc Hdac1 Tcf7l1 Tert Tbxt EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Shc1 Irs2 Stat5a Ptpn11 Stat1 Pik3r1 Rap1a Gab1 Lyn Grb2 Mapk8 Sos1 Hras Bcl2l1 Plcg2 Plcg1 Inpp5d Ptpn6 Cbl Epo Btk Mapk14 Crkl Socs3 Stat5b Vav2 Epor Tec Nfkb1 Bcl2 Jak2 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Map2k6 Map3k7 Map3k1 Map2k3 Atm Traf6 Tab2 Mapk14 Map3k3 Mapk11 Txn1 Camk2b Gadd45g Gadd45b Taok1 Taok3 Map3k6 Rac1 Map3k4 Traf2 Gadd45a Map3k10 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Gsk3b Ruvbl1 Axin1 Zbtb17 Hbp1 Cdkn2a Max Ppp2r5a Skp2 Actl6a Pak2 Myc Taf9 Kat5 Pin1 Ruvbl2 Ppp2ca Kat2a Supt7l S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Abcc1 Sphk1 S1pr1 Gnai1 Plcb2 Gnai3 Ptgs2 Gnaz Pdgfrb Gnao1 Gnai2 Vegfa Pdgfb Mapk1 Mapk3 Rhoa Rac1 Plcg1 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Prnp Pla2g2a Slit2 Fgfr1 Serpinc1 Src Cripto Blk App Lama1 Vegfa Fyn Lyn Yes1 Fgr Hck Smad2 Flt1 Tgfb1 Tgfb3 Fgf2 Lck Tgfbr1 Tgfbr2 Nrg1 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Gna14 Gnaq Src Gnai1 Raf1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Prkca Crk Map2k2 Hras Map2k1 Gnal Pla2g4a Prkcd Col3a1 Adcy7 Mmp1 Jak2 Prkcb Prkce Ednrb Ednra Adcy3 Prkcq Plcb2 Adcy4 Adcy1 Adcy2 Adcy8 Adcy5 Adcy6 Edn2 Edn3 Prkch Cysltr2 Cysltr1 Edn1 Mapk8 Mapk1 Jun Mapk3 Rhoa Bcar1 Plcb3 Slc9a1 Rac1 Fos Plcb1 Trpc6 Slc9a3 Ptk2b Prkcg Mapk14 Akt1 Gna11 Col1a2 Gna15 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Nrp1 Vegfd Nrp2 Vegfc Flt4 Pgf Flt1 Vegfa NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Map2k4 Prkci Pik3r1 Nck1 Fyn Grb2 Mapk8 Nphs2 Jun Nphs1 Tjp1 Cd2ap Kirrel1 Rac1 Bad Pard6a Plcg1 Trpc6 Mapk9 Pik3cb Nck2 Arrb2 Mapk10 F2rl2 Akt1 Prkcz LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Gna14 Gnaq Src Egfr Pxn Gnai1 Gnai3 Gna12 Gnaz Gab1 Gnao1 Gnai2 Tiam1 Ptk2 Crk Hras Plcg1 Nherf2 Gsk3b Prkcd Pik3cb Adcy7 Casp3 Nfkb1 Prkce Nfkbia Rela Adcy3 Adcy4 Adcy1 Adcy2 Pld2 Adcy8 Pik3r1 Adcy5 Adcy6 Lyn Jun Gna13 Rhoa Lpar4 Bcar1 Plcb3 Lpar3 Rac1 Lpar2 Fos Lpar1 Arhgef1 Adra1b Mmp2 Ptk2b Mmp9 Hbegf Gnb1 Prkd1 Akt1 Gna11 Gna15 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Lama4 Vtn Fn1 Fgb Fga Lama1 Lama3 Vegfa Col18a1 Col11a1 Col11a2 Col2a1 Col3a1 Col1a1 Col4a3 Col5a2 Col6a2 Col4a1 Lamc1 Col5a1 Mdk Col4a5 Jam2 Cd81 Lama5 Vcam1 Igsf8 Cd14 Thbs2 Itga10 Itga3 Itga7 Itga8 F13a1 Itga5 Itga6 Itga9 Itgb1 Tgm2 Itga4 Itga1 Itga2 Lamb2 Lamb3 Lama2 Lamb1 Itgav Spp1 Nid1 Cspg4 Plau Fbn1 Fgg Col1a2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Plg Itgb1 Src Itgam Egfr Vtn Serpine1 Fn1 Itgb2 Fgb Dock1 Pdgfrb Fga Crk Itgav Bcar1 Rac1 Ctsg Fpr1 Klk4 Mmp9 Fpr3 Fpr2 Plau Lrp1 Gpld1 Mmp12 Mmp13 Fgg Tgfb1 Ctrc Hgf Vldlr Mmp3 Elane Itga3 Itga5 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Ndrg2 Tjp2 Rbl1 Brca1 Max Pdgfrb Sp1 Ddit3 Id2 Ccl5 Ccnd1 Gadd45a Cflar Smad2 Smad3 Smad4 Zbtb17 Cdkn1a Cdkn1b Hdac3 Wnt5a Lgals1 Itga6 Itgb1 Itgb4 Dntt Spi1 Dkk1 Erbb2 Tmeff2 Gfi1 Aldh9a1 Clu Irf8 Fth1 Tmem126a Sfrp1 Ptpa Tbp Csde1 Tsc2 Myc Hmgcs2 Hdac1 Nfyb Nfya Nfyc Cebpa Zfp36l1 Cdkn2b Dnmt3a Foxo3 Gtf2h2 Bcl2 Slc11a1 Creb1 Sfxn3 Col1a2 Ndrg1 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Erbb2 Erbb4 Areg Tgfa Egfr Ereg Hbegf Nrg2 Btc Nrg4 Nrg3 Egf Hsp90aa1 Erbb3 Nrg1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Tubb2a Ankra2 Rfxank Gata2 Hdac11 Nr3c1 Hdac10 Ranbp2 Xpo1 Hdac4 Ube2i Camk4 Ran Ywhae Ywhab Srf Ncor2 Esr1 Grk2 Mef2c Gnb1 Bcl6 Hsp90aa1 Gata1 Hdac3 Hdac7 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Shc1 Eif2a Smurf1 Strap Dynlrb1 Axin1 Dab2 Dact2 Tgfbrap1 Xiap Zfyve16 Ppp2cb Tab2 Tgfbr3 Sptbn1 Nedd4l Ppp2r2a Rnf111 Ppp1r15a Zfyve9 Ctnnb1 Smurf2 Bambi Ywhae Grb2 Pdpk1 Sos1 Camk2a Fkbp1a Ppp2ca Pard6a Map3k7 Smad2 Smad3 Smad4 Rps6kb1 Ccn2 Tgfb1 Tgfb3 Arrb2 Smad7 Ppp1ca Cav1 Itch Wwp1 Tgfbr1 Tgfbr2 Daxx ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Itgb7 Cdh1 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Prkcb Map2k4 Map3k7 Map3k1 Lat Crkl Map3k8 Grap2 Dbnl Mapk8 Map4k1 Jun Crk Lcp2 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Prkcb Mef2d Prkce Bax Csnk2a1 Prkcq Xpo1 Prkch Camk4 Map3k8 Ywhah Kpnb1 Ran Ywhag Ywhae Nr4a1 Mapk8 Fkbp8 Prkca Kpna2 Ywhab Chp1 Rcan2 Mapk3 Bcl2l1 Fkbp1a Sfn Prkaca Bad Gsk3b Cabin1 Prkcd Crebbp Ywhaz Mapk9 Akap5 Prkcg Map3k1 Pim1 Casp3 Nfatc3 Nfatc2 Csnk1a1 Mapk14 Prkcz Bcl2 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Shc1 Lat Ptpn11 Nck1 Rap1a Map3k8 Grb2 Dbnl Prkca Pdpk1 Sos1 Sla2 Orai1 Hras Stim1 Flna Stk39 Rassf5 Ikbkb Fyb1 Sh3bp2 Ikbkg Plcg1 Vav1 Cd3g Cd247 Malt1 Cd3d Cd28 Traf6 RT1-Da Cd86 Bcl10 Cd80 Ptprc RT1-Db1 Itk Grap2 Cd3e Map4k1 Cd4 Kras Lcp2 Nras Prkcb Prkce Rasgrp1 Prkcq Rasgrp2 Fyn Zap70 Inpp5d Ptpn6 Cbl Pten Chuk Map3k14 Akt1 Gab2 Lck Trpv6 Csk VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Prkcb Rasa1 Cbl Hif1a Flt1 Shc2 Ptpn11 Pik3r1 Nck1 Vegfa Cav1 Nrp1 Nos3 Nrp2 Prkca Mapk1 Pgf Hsp90aa1 Pdpk1 Mapk3 Akt1 Cd2ap Prkaca Plcg1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Shc1 Edn1 Egf Grb2 Mtor Egfr Ednra Sos1 Hras HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Gnai1 Gnai3 Gnaz Gnao1 Xpo1 Gnai2 Pias1 Sap18 Map2k1 Prkaca Rab23 Gli1 Rbbp7 Gli2 Mtss1 Gsk3b Shh Ift88 Foxa2 Prkcd Kif3a Fbxw11 Crebbp Stk36 Smo Sufu Ptch1 Spop Gnb1 Csnk1a1 Csnk1g3 Btrc Csnk1g1 Arrb2 Csnk1g2 Hdac2 Hdac1 Akt1 Csnk1d Csnk1e Lgals3 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Shc1 Rasa1 Irs1 Prkci Grb10 Akt2 Ptpn11 Pik3r1 Nck1 Dok1 Trip10 Grb2 Pdpk1 Sos1 Rhoq Crk Hras Exoc3 Eif4ebp1 Exoc5 Pard6a Exoc6 Inpp5d Exoc2 Cbl Exoc7 Rps6kb1 Nck2 Cav1 Ptpra F2rl2 Ins2 Sh2b2 Akt1 Grb14 Prkcz Sgk1 Insr Foxo3 Ptpn1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfb Pdgfra Pdgfc Pdgfrb Pdgfa EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Shc1 Cbl Src Acp1 Efna1 Pik3r1 Tiam1 Ptk2 Epha2 Vav2 Arhgap35 Grb2 Pak1 Inppl1 Rhoa Bcar1 Rac1 Vav3 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Sh2d2a Src Egfr Raf1 Rictor Mapkap1 Gab1 Ppp2r2a Mlst8 Braf Ywhah Nckap1 Elk1 Ywhag Ywhae Egf Grb2 Prkca Wasf2 Pdpk1 Sos1 Map2k2 Ywhab Hras Map2k1 Abi1 Atf1 Usp6nl Sfn Egr1 Bad Eps8 Rab5a Prkcd Ywhaz Mapk9 Dusp1 Pik3cb Mef2c Arf4 Rps6ka5 Ppp5c Zfp36 Map3k2 Brk1 Myl11 Map2k5 Dusp6 Baiap2 Ralgds Vav2 Arpc1b Actr2 Actr3 Arpc3 Arpc2 Kras Prkcz Arpc5 Arpc4 Nras Map2k4 Pebp1 Pld1 Rin1 Stat3 Pld2 Stat1 Pik3r1 Rps6ka3 Capn2 Mapk8 Mapk1 Jun Mapk3 Bcl2l1 Rala Srf Ppp2ca Slc9a1 Rac1 Fos Map3k1 Mtor Ppp2r1a Iqgap1 Atf2 F2rl2 Smad1 Rps6 Akt1 Creb1 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Csnk2a1 Nudc Dynlt1 Abl1 Map1b Ywhae Rhoa Rac1 Lrpap1 Iqgap1 Vldlr Pafah1b3 Pafah1b2 Lrp8 Pafah1b1 Dab1 Dync1h1 Ppp2r5d Pla2g7 Cdk5 Katna1 Cdk5r2 Cdk5r1 Ndel1 Reln Dcx SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Agt Rabggtb Atf5 Itgb1 Src Itga1 Cdk2 Rhoc Cdkn1a Ccne1 Ccna2 Mapk1 Mapk3 Rock1 Rhoa Bcar1 Egr1 Ptp4a3 Rac1 Ptp4a1 Rabggta EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Map2k4 Rgs3 Map3k7 Src Itga2b Blk Pik3r1 Nck2 Ephb1 Ephb2 Fyn Lyn Tiam1 Yes1 Efnb1 Efnb2 Fgr Mapk8 Hck Dnm1 Lck Ptpn13 Rac1 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Shc1 Map2k4 Itgb1 Vegfd Col1a1 Vegfc Rps6ka1 Itga4 Fn1 Itga1 Itga2 Pik3r1 Mapk14 Mapk11 Grb2 Flt4 Mapk1 Sos1 Crk Mapk3 Akt1 Creb1 Col1a2 Itga5 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Gna14 Gnaq Gulp1 Src Fbxo8 Itga2b Pxn Acap2 Egfr Lhcgr Arap2 Nck1 Cyth2 Tshr Egf Cyth3 Agtr1a Adrb2 Git1 Acap1 Adap1 Arrb1 Efna1 Arf6 Hgf Arrb2 Epha2 Met Gna11 Gna15 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Serpine1 Cdk6 Rack1 Ada Rchy1 Sp1 Ccna2 Tp63 Kat5 Serpina1 Casp2 Ntrk1 Sfn Hey2 Plk3 Cdk2 Fas Rb1 Cdkn1a Mapk11 Prkacb Plpp1 Gata1 Sirt1 Bax Rela Pfdn5 Tuba1a Ccne2 Pea15 Il1rap Clca2 Jag2 Ndufs2 Nedd4l Hagh Abl1 Gramd4 Aen Mdm2 Dcp1b Rnf43 Jak1 Dedd Flot2 Afp Hsf1 Wt1 Bub1 Bak1 Chek1 Ube4b Tp73 Nsg1 Gdf15 Ccnb1 Wwox Plk1 Bin1 Brca2 Cdk1 Mapk14 Il4r Bcl2l11 Itch Myc Pin1 Foxo3 Rad51 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Nras Src Gnai1 Raf1 Rictor Gnai3 Pik3r1 Gnaz Mapkap1 Gnao1 Mlst8 Gnai2 Mapk1 Pdpk1 Dnm1 Map2k2 Hras Mapk3 Map2k1 Cxcl11 Cxcl10 Cxcr3 Map2k6 Pf4 Cxcl13 Arrb1 Mtor Pik3cb Gnb1 Ccl11 Map2k3 Mapk14 Mapk11 Cxcl9 Akt1 Kras IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Inpp5d Shc1 Csf2rb Ywhaz Cnksr1 Il3ra Cish Srp9 Stat5a Pim1 Ptpn11 Pik3r1 Id1 Osm Cebpb Stat5b Prkacb Ywhag Grb2 Hdac1 Bcl2l1 Gab2 Prkaca Jak2 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Gna14 Gnaq Src Egfr Gna12 Gnai2 Nos3 Egf Prkca Dnm1 Rock1 Sele Nherf1 Prkcd Grk2 Icam1 Mapk11 Rab11a Vcam1 Prkcz Prkcb Prkce Blk Tgm2 Arr3 Prkcq Plcb2 Fyn Gnb5 Prkch Lyn Yes1 Fgr Hck Gna13 Rhoa Prkaca Pik3r6 Rac1 Pik3cg Arhgef1 Syk Grk3 Prkcg Ptgdr Gnb1 Ptgir Tbxa2r Mapk14 Arrb2 Akt1 Lck Gna11 Gna15 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Shc1 Itga6 Il1a Itgb1 Egfr Lama4 Rxrb Itgb4 Rxra Rxrg Pik3r1 Lama1 Lama3 Ywhah Ywhag Lamb2 Ywhae Lamb3 Casp7 Egf Grb2 Cdh1 Lama2 Prkca Lamb1 Erbb3 Ywhab Hras Sfn Rac1 Erbb2 Ywhaz Rps6kb1 Col17a1 Pmp22 Lamc1 Mst1r Lama5 Met Mst1 Akt1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Irs1 Raf1 Rictor Mapkap1 Mlst8 Braf Ywhah Ywhag Srebf1 Ywhae Prkca Pdpk1 Map2k2 Ywhab Hras Map2k1 Sfn Ikbkb Eif4ebp1 Ywhaz Eif4e Eif4a1 Ppargc1a Cdk2 Yy1 Kras Cycs Nras Rps6ka1 Pld1 Pld2 Rptor Mapk1 Mapk3 Akt1s1 Fbxw11 Mtor Rps6kb1 Prr5 Rraga Btrc Ddit4 Rragb Rragc Rragd Tsc1 Eef2k Eif4b Ulk1 Ccne1 Ulk2 Tsc2 Rb1cc1 Rrn3 Poldip3 Pdcd4 Akt1 Bnip3 Atg13 Sgk1 Eef2 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Nfkb2 Chuk Map3k14 Nfkb1 Btrc DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Casp6 Tgfa Egfr Serpine1 Atf3 Sp1 Tp63 Col18a1 Taf9 Kat2a Vdr Pou4f1 Crebbp Pou4f2 Bid Cd82 E2f3 Plk3 Bcl2a1 Fas Rb1 Cdkn1a Ctsd Bax Mdm2 Afp Bak1 Tp73 Spp1 Gdf15 Ccnb1 Foxa1 Mmp2 Pten Apc Cse1l Ddit4 Bdkrb2 Cav1 Igfbp3 Ccng1 Drosha Tp53 Ccnk Carm1 Pcbp4 Tap1 Hic1 Ppp1r13b Pcna Msh2 Perp Tyrp1 Tnfrsf10b Sh2d1a Sesn1 Steap3 Tada2b Fdxr Ddx5 Btg2 Apaf1 Lif Rrm2b Tp53bp2 Prmt1 Rchy1 Bcl2l14 Gpx1 Bcl2l2 Bnip3l Pidd1 Rnf144b Triap1 Irf5 Serpinb5 Aifm2 Dgcr8 Htt Scn3b Casp1 Zfp385a Sfn Pms2 Cx3cl1 Vcan Pycard Mlh1 Gadd45a Tp53inp1 Tigar Dusp5 Cebpz Nlrc4 Dusp1 Prdm1 Prkab1 Ppm1j Hgf Epha2 Smarca4 Met Edn2 Dkk1 Jun Bcl2l1 Mcl1 Bcl6 Hdac2 Tsc2 Nfyb Nfya Nfyc Bcl2 E2f1 Ndrg1 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Prkce Adcy3 Rps6ka5 Adcy4 Adcy7 Adcy1 Adcy2 Adcy8 Adcy5 Adcy6 Gnal Lpar4 Prkaca Creb1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Src Adam10 Hgs Egfr Gdnf Gfra1 Gna12 Abl1 Fyn Tiam1 Ctnnb1 Egf Cdh1 Jup Ntrk2 Rin2 Hras Gna13 Igf1r Rac1 Ctnna1 Rab7a Rab5a Ptpn6 Nme1 Crebbp Snx1 Dnm2 Mmp7 Slit1 Cbll1 Dsp Casp3 Ctnnd1 Iqgap1 Cables1 Igf2 Arf6 Robo1 Zbtb33 Mmp3 Met Cdh2 Ret Ptpn1 Bdnf AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Rasa1 Tacc1 Nfkbia Brca1 Aurkb Mdm2 Ran Arhgef7 Fzr1 Pak1 Git1 Prkaca Gadd45a Gsk3b Ajuba Tpx2 Aurkaip1 Oaz1 Cpeb1 Dlgap5 Tacc3 Tdrd7 Aurka Cenpa Cdc25b Ppp2r5d Akt1 Ndel1 Ckap5 Tp53 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Map2k4 Nfkbia Rela Stat5a Pik3r1 Jak3 Mapk8 Jun Bcl2l1 Pik3r6 Birc2 Pik3cg Il4 Birc3 Mapk9 Cd40lg Pik3cb Map3k1 Map3k14 Traf6 Mapk14 Mapk10 Mapk11 Fcamr Traf3 Cd40 C4bpa Myc Tdp2 Cblb Akt1 Nfkb1 Traf2 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network Nr0b1 Nr0b2 Smarce1 C3 Ncoa2 Smarca4 Ncoa1 Esr2 Smarcb1 Uba3 Zfp709 Nedd8 Ube2m SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurka Aurkc Aurkb LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Cab39 Strada Etv4 Mark2 Stk11 Psen2 Sik1 Brsk2 Brsk1 Mlst8 Rptor Ywhah Ywhag Ywhae Ywhab Akt1s1 Sfn Prkaca Esr1 Gsk3b Ywhaz Mtor Smad4 Ezr Tsc1 Ctsd Tsc2 Hsp90aa1 Myc Cdc37 Stk11ip Stk26 Mark4 Crtc2 Tp53 Map2 Stradb Creb1 Smarcd3 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb3 Efnb1 Efnb2 Ephb1 Ephb2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Nras Rps6ka1 Raf1 Ntf3 Rap1a Braf Rit1 Rit2 Elk1 Ehd4 Rap1b Mapk1 Hras Mapk3 Map2k1 Srf Trpv1 Egr1 Fos Map2k6 Prkcd Mef2c Map2k3 Rps6ka5 Map3k2 Mapk14 Map2k5 Cdk5 Cdk5r1 Kras Creb1 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Sqstm1 Rela Prkci Nrk Map4k5 Map4k3 Stat1 Tnfrsf1b Tab2 Rack1 Cyld Map4k2 Rffl Ikbkb Birc2 Ikbkg Map2k7 Birc3 Map3k7 Adam17 Map3k1 Casp8 Tnik Map2k3 Chuk Ripk1 Map3k3 Fadd Cav1 Smpd2 Txn1 Smpd1 Tnf Nsmaf Madd Tnfrsf1a Bag4 Prkcz Nfkb1 Traf2 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Nr3c1 Pklr Cebpb Tat Dlk1 Aldob Nkx2-1 Acadvl Hmgcs1 Sp1 Ttr Afp Igfbp1 Slc2a2 Ucp2 Pck1 Acadm Gck Cpt1a Bdh1 Abcc8 Kcnj11 Foxa1 Alb Foxa2 Hnf1a Tfrc Foxa3 Cpt1b Cpt1c Hadh Hnf4a Ins2 Nf1 G6pc1 Cebpa Akt1 Creb1 F2 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Src Raf1 Tiam1 Braf Enah Hras Dlg1 Map2k7 Eps8 Gsk3b Map2k6 Mapk9 Arhgdia Baiap2 Iqgap3 Vav2 Arpc1b Actr2 Actr3 Pak2 Arpc3 Arpc2 Prkcz Arpc5 Arpc4 Map3k11 Map2k4 Prkce Pld1 Pik3r1 Yes1 Ctnnb1 Arhgef7 Mapk8 Cdh1 Pak1 Mapk1 Arhgef6 Jun Pak4 Mapk3 Bcar1 Rac1 Ctnna1 Pard6a Cfl1 Cbl Cdc42bpa Map3k1 Mtor Apc Septin2 Exoc7 Pax6 Map2k3 Myl2 Rps6kb1 Hes5 Iqgap1 Tnk2 Limk1 Limk2 Atf2 Mapk14 F2rl2 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Hgs Src Pxn Gnai1 Rictor Gnai3 Ptpn11 Rack1 Gnaz Mapkap1 Gnao1 Mlst8 Gnai2 Ptk2 Rap1b Pdpk1 Dnm1 Crk Bad Grk2 Vav1 Cd3g Pik3cb Cd247 Cd3d RT1-Da Stat2 Rhoc Ptprc Rhob RT1-Db1 Cd3e Cd4 Prkcz Jak2 Cxcr4 Ssh1 Blk Stat5a Arr3 Plcb2 Stat3 Stat1 Pik3r1 Fyn Lyn Yes1 Fgr Hck Pak1 Gna13 Rhoa Bcar1 Plcb3 Pik3r6 Rac1 Pik3cg Plcb1 Inpp5d Ptpn6 Cfl1 Ptk2b Mmp9 Mtor Gnb1 Cxcl12 Limk1 Rgs1 Ubqln1 Vps4a Vps4b Grk6 Arrb2 Stat5b Ralb Itch Akt1 Lck Foxo1 Csk P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Hspb1 Ywhaz Mapkapk3 Raf1 Th Tcf3 Mapk14 Etv1 Mapk11 Lsp1 Ywhah Cdc25b Ywhag Ywhae Tsc2 Ywhab Srf Sfn Creb1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Adam10 Fzd1 Csnk2a1 Axin1 Kremen2 Dll1 Ppard Dkk1 Ncstn Aph1b Ctnnb1 Mapk1 Jun Psenen Mapk3 Psen1 Fos Ccnd1 Gsk3b Hnf1a Nedd4 Fbxw11 Crebbp Map3k7 Apc Csnk1a1 Btrc Tle1 Tle5 Dkk2 Notch1 Ctbp1 Ppp2r5d Myc Hdac1 Nlk Lrp6 Wif1 Dvl1 Wnt1 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Perp Bax Itgb4 Fdxr Clca2 Ada Jag1 Abl1 Aen Mdm2 Sp1 Flot2 Tp63 Serpinb5 Ikbkb Gdf15 Vdr Gadd45a Plk1 Shh Prkcd Chuk Cables1 Hbp1 Cdkn2a Egr2 Fas Btrc Cdkn1a Dhrs3 Igfbp3 Traf4 Ogg1 Spata18 Itch Tfap2c Nqo1 Noc2l Gpx2 Evpl Itga3 Ssrp1 Dicer1 Wwp1 Mfge8 Smarcd3 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Ptpn2 Il1b Stat3 Ptpn11 Stat1 Pik3r1 Socs1 Rap1a Ifngr1 Cebpb Pias1 Jak1 Dapk1 Rap1b Mapk1 Camk2a Mapk3 Casp1 Map2k1 Prkcd Crebbp Cbl Camk2d Ifng Mtor Map3k1 Crkl Smad7 Irf1 Pias4 Camk2b Akt1 Ptges2 Camk2g Jak2 Irf9 Map3k11 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Uso1 Kdelr1 Gga3 Ap2a1 Arfip2 Clta Gosr2 Cltb Arfgap1 Pld2 Asap1 Arf1 Cyth2 Cd4 Rac1 Ap2m1 Gbf1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Il1a Sqstm1 Rela Prkci Ube2v1 Il1b Ticam2 Irak3 Erc1 Tab2 Pik3r1 Il1rap Tollip Il1r2 Il1rn Mapk8 Ube2n Jun Irak1 Casp1 Ikbkb Myd88 Ikbkg Irak4 Map2k6 Map3k7 Chuk Traf6 Map3k3 Prkcz Nfkb1 Il1r1 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Gata3 Smarcc1 Nr3c1 Nr1i3 Tsg101 Kmt5b Ncoa2 Ywhah Fkbp5 Ncoa1 Sumo2 Il5 Nr4a1 Pou1f1 Smarcd1 Cga Pck2 Pomc Krt17 Pbx1 Smarcc2 Sfn Egr1 Bglap Gsk3b Sele Crebbp Mapk9 Il13 Ppp5c Mmp1 Cdkn1a Tbx21 Icam1 Mapk10 Mapk11 Irf1 Smarca4 Prkacb Il6 Cdk5 Cdk5r1 Nfkb1 Bax Rela Stat5a Stat1 Spi1 Fkbp4 Mdm2 Mapk8 Mapk1 Afp Jun Mapk3 Prkaca Fos Il2 Il4 Pou2f1 Ifng Csf2 Fgg Mapk14 Stat5b Hdac2 Tbp Prl Hsp90aa1 Hdac1 Akt1 Csn2 Sgk1 Krt14 Tp53 Creb1 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Nras Shc1 Spry2 Src Hgs Egfr Ube2d3 Raf1 Pik3r1 Tsg101 Ptk2 Arhgef7 Egf Sh3kbp1 Grb2 Eps15 Synj1 Sos1 Dnm1 Itsn1 Hras Stambp Usp8 Amph Chmp3 Epn1 Ube2d2 Rab5a Zfyve28 Lrig1 Cbl Pik3cb Sh3gl2 Ube2d1 Cblb Kras E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Tfe3 Hic1 Rbl1 Topbp1 Serpine1 Brca1 Xrcc1 Atm Apaf1 Cdc25a Sp1 Casp7 Ccna2 Kat2a Uxt Tfdp2 Crebbp Ces1d Cdkn2c Tyms Mybl2 Sult2a1 Ranbp1 E2f3 Ces2h Cdk2 Hbp1 Mcm3 Ces4a Dhfr Rb1 Cdkn1a Orc1 E2f5 Ces5a Rrm2 E2f6 Rbbp8 E2f7 Yy1 Wasf1 Cdkn1b Prmt5 Cbx5 Sirt1 Ccne2 Tp73 Ccnd3 Plau Mcl1 Cdkn2a Cdk1 Cdc6 Smarca2 Ccne1 Myc Hdac1 Trim28 Rbl2 Cebpa E2f1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Nfkbia Rela Ube2d3 Chuk Malt1 Atm Traf6 Bcl10 Erc1 Cyld Btrc Xpo1 Ran Tnf Prkca Ripk2 Tnfrsf1a Ikbkb Nfkb1 Birc2 Ikbkg EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Efna5 Fyn TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Shc1 Lat Rap1a Map3k8 Grb2 Prkca Pdpk1 Sos1 Orai1 Hras Stim1 Rassf5 Ikbkb Ikbkg Plcg1 Vav1 Cd3g Cd247 Prf1 Malt1 Cd3d Cd28 Traf6 Cd86 Bcl10 Cd80 Ptprc Grap2 Cd3e Kras Lcp2 Nras Prkcb Prkce Rasgrp1 Prkcq Rasgrp2 Cd8b Cd8a B2m Fyn Zap70 Ptpn6 Cbl Chuk Map3k14 Akt1 Lck Trpv6 Csk REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Rad50 Egfr Xrcc6 Xrcc5 Atm Max Terf2 Ywhae Nr2f2 Sp1 Egf Sap18 Sp3 Ccnd1 Rbbp7 Esr1 Smad3 Irf1 Terf1 Smg6 Tinf2 Parp2 Pot1 Acd Cdkn1b Znfx1 Terf2ip Hnrnpc Pinx1 Nfkb1 Abl1 Mxd1 Ube3a Mapk1 Jun Wt1 Mapk3 Blm Fos Il2 Ifng Hus1 Mtor Rps6kb1 Tgfb1 Rad1 Hdac2 Hsp90aa1 Myc Mre11 Hdac1 Akt1 Tert Nbn E2f1 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Cbx4 Raf1 Cdk6 Myod1 Cebpb Sftpd Ccna2 Gsc Runx2 Ccnd1 Mitf Bglap Ccnd2 Tgfb2 Crebbp Mapk9 Mef2c Ubtf Cdk4 E2f3 Cdk2 Rb1 Cdkn1a Mapk11 Smarca4 Met Smarcb1 Cdkn1b Hdac3 Suv39h1 Brd2 Pax3 Pparg Aatf Rbp2 Atf7 Ckm Sirt1 Dnmt1 Taf1 Spi1 Abl1 Mdm2 Elf1 Jun Ppp2ca Ccnd3 Csf2 Cdkn2a Atf2 Mapk14 Skp2 Tbp Ccne1 Ctbp1 Hdac1 Cebpa E2f1 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Smad2 Smad3 Ppm1a Map3k1 Smad4 Nup153 Ctdspl Tgfbrap1 Ube2i Kpnb1 Pias4 Mapk1 Kpna2 Ctdsp1 Mapk3 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Lep Serpine1 Eno1 Hmox1 Vegfa Tf Ncoa2 Ncoa1 Sp1 Id2 Arnt Tfrc Crebbp Hif1a Smad3 Smad4 Hdac7 Furin Npm1 Nos2 Cxcr4 Gata2 Plin2 Adm Itgb2 Cp Pfkfb3 Nt5e Pgm1 Fech Pkm Aldoa Ets1 Abcb1a Pfkl Rora Edn1 Hk2 Bhlhe41 Igfbp1 Ca9 Jun Gck Fos Cops5 Tff3 Cxcl12 Mcl1 Epo Bhlhe40 Hnf4a Egln3 Cited2 Pgk1 Slc2a1 Abcg2 Akt1 Bnip3 Tert Creb1 Ndrg1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Itgb1 Pik3r1 Rap1a Fyn Map1b Mapk8 Grin2a Mapk8ip1 Arhgef2 Map2k7 Gsk3b Cbl Lrpap1 Vldlr Crkl Nck2 Grin2b Lrp8 Pafah1b1 Dab1 Cdk5 Akt1 Cdk5r1 Itga3 Reln Map3k11 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Map2k4 Cflar Tnfrsf10b Map3k1 Pik3cb Casp8 Chuk Ripk1 Pik3r1 Fadd Smpd1 Mapk8 Mapk1 Dap3 Mapk3 Tnfsf10 Ikbkb Ikbkg Traf2 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Mapk9 Mapk8 Gnb1 Gnal Crh Mapk14 Mapk11 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Shc1 Eif2a Itgb1 Src Ptpn2 Egfr Stat5a Itga1 Stat3 Stat1 Atr Pik3r1 Pdgfrb Stat6 Gab1 Vegfa Pdgfb Kpnb1 Jak3 Pias1 Jak1 Egf Grb2 Kpna2 Sos1 Rab4a Lman1 Crebbp Pik3cb Hgf Stat5b Met Ins2 Eif2ak2 Csf1r Csf1 Insr Ptpn1 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Smurf1 Ppm1a Ctdspl Xiap Bmp7 Zfyve16 Tab2 Ppp1r15a Smurf2 Bambi Mapk1 Ctdsp1 Grem1 Ahsg Sostdc1 Rgma Gsk3b Hjv Chrd Map3k7 Fst Nog Bmpr1a Bmp6 Smad4 Bmp2 Smad6 Chrdl1 Smad7 Ppp1ca Bmpr2 Smad1 Smad9 Bmp4 Smad5 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events Gna14 Gnaq Gnb1 Rock2 Plcb2 Myl2 F2rl2 Gna13 Rock1 Rhoa Gna11 F2 Gna15 FSH%NETPATH%FSH FSH Map2k2 Grk4 Fshb Fshr Akt2 Grk6 Cga HEDGEHOG%NETPATH%HEDGEHOG Hedgehog Prkaca Ctnnb1 Gli1 Kif7 Med6 Gli2 Grk2 Ywhae Ptch1 Sap18 Dyrk1a Sufu Boc Arrb2 Kif27 Med23 Med12 Med1 Ccnb1 Dhh Hhip Ihh Stk36 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor Ar Hdac1 Akt1 Hspb1 Pik3r1 Ptk2 Creb1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor Arrb2 Ar Hdac1 Akt1 Pik3r1 Ptk2 Atf2 Ccne1 Fkbp1a Mapk1 Irf2bp1 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Ube2i Myc Tp53 Skp1 Pdk1 Pard6a Ctnna2 Ctnna1 Dcp1a Rbx1 Eid2 Ube2d3 Ube2d2 Ube2d1 Nup153 Sik1 Btrc Cdc25a Atf3 Jund Pxn Sdc2 Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Tp73 Jun Cops5 Vdr Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Stk11 Hspa8 Map4k1 Ppp1r15a Snw1 Wwtr1 Sparc Cdk6 Smad4 Fnta Cdk4 Cul1 Cdc16 Junb Smad6 Daxx Hnf4a Ing2 Xpo1 Pdpk1 Ctcf Foxo4 Tfdp2 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Zeb1 Gsk3b Rbl2 Zeb2 Anapc10 Smurf1 Crk Pik3r2 Stk11ip Nfyb Nfya Ppm1a Nfyc Prkar1b Hoxa7 Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Runx3 Runx1 Cd44 Runx2 Rb1 Tgfbr3 Prkar2a Trim33 Map2k3 Mef2c Brca1 Zfyve9 Cdkn1a Tgfbr2 TCR%NETPATH%TCR TCR Map2k2 Ctnnb1 Dyrk1a Creb1 Akt1 Pik3r1 Ptk2 Atf2 Mapk1 Mapk3 Pxn Gsk3b Crk Pik3r2 Pard3 Prkd1 Prkd2 Eno2 Crkl Cd2ap Acta1 Plcg1 Cblb Plcg2 Ly9 Wipf1 Prkcd Itsn2 Rasgrp1 Rasgrp2 Vasp Arhgef7 Arhgef6 Rasa1 Txk Arhgef2 Unc119 Cabin1 Rps6kb1 Pttg1ip Pik3ap1 Bcl10 Grap Lnpep Lyn Egr1 Nfkbib Fyb1 Tfrc Pik3c2b Cgn Homer3 Nfkbia Crebbp Kirrel1 Slamf6 Cyfip1 Grb2 Ada Ikbkb Itk Gdi2 Enah Tsg101 Dyrk1b Cltc Cd28 Nfkb1 Jak3 Vav3 Rap1a Diaph1 Syk Skap2 Skap1 Gab2 Vav1 Vav2 Bdh1 Ldhb Tuba4a Zdhhc17 Golga5 Ctla4 Cd3g Actr10 Cd3e Cd3d Dusp3 Pak1 Nfam1 Caskin2 Cct8 Dpysl2 Git2 Ahcy Grap2 Mpzl1 Map2k1 Hnrnph3 Nedd9 Stat1 Dbnl Sh2d3c Mapk8 Tuba1a Sla Map3k8 R3hcc1l Sit1 Dgka Sdcbp Cd86 G6pd Cd84 Sh2d2a Cd82 Snrnp70 Cd80 Lax1 Hsp90ab1 Rela Mtmr10 Dok1 Dok2 Hgs Stk39 Flnb Anxa2 Raf1 Inpp5d Shc1 Stk4 Acly Ripk2 Elmo1 Prp4k Bmf Ptprc Tubb5 Ppp3cb Eprs1 Ptpra Pstpip1 Acbd6 Fer Ogn Cdk1 Lat Itpr1 Zap70 Wdr1 Arhgdib Ddx3x Hdac7 Acp1 Pgm1 Nck1 Nfatc2 Stam2 Anxa11 Msl2 Adam9 Dnm2 Epha3 Pkm Lck Lcp2 Sos1 Ywhaz Lpxn Eif3m Atp1a1 Src Atp1a3 Ptpn6 Trim25 Ptpn3 Cbl Cebpb Dock2 Cd2 Muc1 Cd4 Trat1 Cd5 Cd7 Ptpn11 Ptpn12 Mapk14 Arhgap35 Dnajb1 Ptk2b Sh3bp2 Tec Khdrbs1 Ptpn22 Chuk Ran Mapk11 LEPTIN%NETPATH%LEPTIN Leptin Rps6ka2 Acacb Igf1r Stat1 Rps6kb1 Mapk8 Src Gsk3b Nfkbia Grb2 Ikbkb Ncoa1 Shc1 Runx2 Khdrbs1 Jak3 Chuk Crp Erbb2 Irs1 Pde3a Eif4ebp1 Esr1 Socs7 Prkaa1 Prkaa2 Gnaq Akt1 Slc2a4 Fyn Jak1 Ptk2 Nos3 Rps6 Plcg1 Cfl2 Mapk1 Plcg2 Egfr Eif4e Gsk3a Cdk5 Lep Limk1 Prkce KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor Socs1 Mitf Socs5 Socs4 Matk Stat1 Socs6 Ptpru Mapk8 Gys1 Csf2rb Jak2 Sh3kbp1 Mad2l1 Fgr Gsk3b Hck Prkcb Rps6ka1 Kit Tnfrsf10b Crk Prkca Il7r Spred1 Ezr Spred2 Grb7 Rela Mtor Epor Mapk12 Yes1 Kitlg Rdx Msn Stat5a Raf1 Stat5b Inpp5d Fes Cdk2 Hras Akt1 Crkl Pik3r1 Atf2 Cblb Mapk1 Wipf1 Rasa1 Rps6kb1 Sos1 Grap Src Ptpn11 Mapk14 Cltc Tec Jak3 Jun Eif4ebp1 Fyn Rps6 BCR%NETPATH%BCR BCR Pdpk1 Nedd9 Foxo3 Stat1 Fos Gsk3b Hck Prkcb Rps6ka1 Crk Pik3r2 Rela Dok1 Bcar1 Ctnnb1 Shc1 Cdk2 Rb1 Tcl1a Cd72 Stap1 Elk1 Sla2 Chst15 Bank1 Nfatc3 Cd22 Creb1 Malt1 Prkd1 Cycs Akt1 Plekha1 Hcls1 Crkl Prkcq Gtf2i Ptk2 Atf2 Lat2 Plcg1 Rasgrp3 Itpr1 Zap70 Blnk Mapk1 Btk Pip4k2b Pip4k2c Prkcd Pip4k2a Cd79b Ptpn18 Nck1 Ccl4 Nfatc2 Pik3cg Casp7 Mapkapk2 Rasa1 Casp9 Sh2b2 Ifitm1 Fcgr2b Cdk7 Lck Rps6kb1 Bcl6 Btla Sos1 Bax Bcl10 Stat3 Pip5k1c Hnrnpk Lyn Pip5k1b Itpr2 Ptpn6 Grb2 Ikbkb Itk Mapk14 Sh3bp2 Tec Chuk Jun Vav1 Eif4ebp1 Map4k1 Fyn Rps6 Gsk3a Junb TNFALPHA%NETPATH%TNFALPHA TNFalpha G3bp2 Dcaf7 Cops3 Nfkbie Nlrp4 Kpna6 Mcc Kpna3 Stat1 Kpna2 Cdk9 Mapk8 Zbtb17 Ccnt1 Cyba Map3k8 Diablo Bcl3 Rel Tab2 Traf7 Traf4 Mcm7 Pfdn2 Akt2 Traf6 Faf1 Birc3 Birc2 Ikbkg Hsp90ab1 Csnk2a1 Tnfrsf8 Ikbke Dok1 Ywhah Ywhag Mark2 Psmd12 Tnfrsf1b Hdac2 Smarcb1 Ywhab Psmd13 Alpl Ywhae Rasal2 Akap8 Psmb5 Rpl8l1 Ppp6c Gab1 Bcl2l1 Rack1 Creb1 Fkbp5 Rps6ka5 Hdac1 Smarca4 Akt1 Fadd Hspb1 Mcm5 Smpd3 Ptk2 Tnip2 Psmc2 Psmc1 Psmc3 Mapk1 Polr2h Pdcd2 Ddx3x Nsmaf Map2k5 Itch Zfand5 Mapk3 Cflar Ube2i Bid Trpc4ap Psmd7 Skp1 Psmd6 Pdk1 Fancd2 Psmd3 Psmd2 Casp3 Romo1 Elp1 Sos1 Psmd1 Ube2d3 Ywhaz Casp2 Ube2d2 Trim32 Spag9 Usp11 Src Glb1 Btrc Smarcc2 Prc1 Smarcc1 Rnf25 Pkn1 Lrpprc Map3k11 Mtif2 Trap1 Ptpn11 Mapk14 Jun Irs1 Cav1 Egfr Cul1 Junb Foxo1 Prkca Map2k6 Stat5a Rb1 Gtf2i Casp7 Mapkapk2 Bax Rpl4 Txn1 Mapk9 Nkiras1 Brinp1 Nr2c2 Nkiras2 Nfkbia Erbb3 Crebbp Tbkbp1 Trib3 Rps11 Tnf Grb2 Hsp90aa1 Fbl Ppp1r12a Rpl30 Unc5cl Tbk1 Dpf2 Tax1bp1 Kcnq1 Polr1b Nfkb1 Polr1c Txnip Polr1a Usp2 Xiap Polr1e Fbxw11 Tank Map3k3 Actl6a Map3k2 Rxra Smarce1 Polr2sl1 Tifa Flna Cdc37 Rffl Inpp5e Rasa3 Nfkbiz Papola Pak1 Glg1 Bag4 Ripk3 Cradd ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Fos Prkca Pik3r2 Mtor Ywhah Yes1 Ywhab Shc1 Ywhae Gab1 Ar Akt1 Pik3r1 Ptk2 Mapk1 Prkcd Mapk3 Pik3cg Casp3 Ywhaz Src Clca1 Irs2 Rpsa Rhoa Grb2 Rac1 Plec Ptpn11 Dsp Lama5 Mapk14 Cd151 Itgb4 Lama2 Lama3 Mst1r Mylk3 Met Pik3r3 Tp73 Col17a1 Jun Itga6 Ntn1 Erbb2 Ephb2 Irs1 Lamb2 Lamb3 Eif4ebp1 Sfn Lamb1 Pik3cb Pik3cd Rtkn Bad Fyn Smad2 Smad3 Eif6 Lamc1 Vim Egfr Eif4e Pak1 WNT%NETPATH%WNT Wnt Ppp2ca Sfrp1 Daam1 Dkk1 Mesd Pax2 Prkcg Frzb Dixdc1 Chd7 Mapk8 Axin1 Ror1 Lef1 Lrp1 Arhgef4 Csnk1a1 Nlk Prkcb Lrp5 Gpc3 Dvl3 Wnt2 Prkca Wnt1 Tcf7l2 Wnt3 Fzd1 Jup Fzd5 Fzd4 Fzd6 Kremen1 Yes1 Fzd9 Mark2 Smad1 Prkaca Pin1 Tcf4 Ywhab Arrb2 Akt1 Prkcd Nfatc2 Pip5k1b Rhoa Rac1 Jun Ccnd1 Cdk6 Map3k7 Ctbp1 Wnt5a Cdh1 Pi4k2a Ppp1ca Sfrp2 IL6%NETPATH%IL6 IL6 Map2k1 Foxo4 Foxo3 Stat1 Foxo1 Cdk9 Mapk8 Fos Fgr Gsk3b Hck Nlk Map2k2 Pik3r2 Map2k6 Ncoa1 Socs3 Stat5a Map3k4 Stat5b Pias3 Cd40 Shc1 Sgk1 Rb1 Il6st Il6 Il6r Bmx Eif2a Gab1 Map2k4 Ar Hdac1 Akt1 Hspb1 Pik3r1 Plcg1 Mapk1 Btk Prkcd Mapk3 Rps6kb1 Stat3 Lyn Cbl Erbb3 Crebbp Grb2 Hsp90aa1 Rac1 Ptpn11 Mapk14 Ptk2b Nfkb1 Jun Erbb2 Gab2 Vav1 Eif4ebp1 Bad Fyn Jak1 Map3k7 Eif4e Daxx TSH%NETPATH%TSH TSH Igf1r Raf1 Map2k3 Gna12 Gna11 Atp1a1 Creb1 Gnao1 Gna13 Tshr Hspa5 Gnaq Canx Gnai2 Gnai1 Calr Scrib Gnai3 Ikbkb Map2k6 Lep Mapk3 EGFR1%NETPATH%EGFR1 EGFR1 Map2k2 Ywhab Dyrk1a Gab1 Creb1 Rps6ka5 Hdac1 Pik3r1 Ptk2 Mapk1 Itch Myc Tp53 Jund Irs2 Dab2 Rhoa Rac1 Plec Dsp Itgb4 Sp1 Met Pik3r3 Col17a1 Jun Ephb2 Cav1 Pik3cb Stk11 Pik3cd Bad Smad2 Smad3 Vim Ctbp1 Cdh1 Pdpk1 Foxo4 Prkcg Zfyve16 Foxo1 Fos Arhgef4 Gsk3b Crk Pik3r2 Jup Ap2b1 Socs3 Map3k4 Pias3 Map2k3 Pard3 Prkd1 Crkl Plcg1 Scrib Cblb App Plcg2 Spart Atf1 Myl12b Prkcd Il17rd Itsn2 Mprip Nedd4 Eno1 Vasp Nectin1 Arhgef7 Rps10 Elk4 Gja1 Tfg Tns4 Scamp3 Tns2 Rps6kb1 Tns1 Pttg1ip Ralb Krt8 Otud6b Cblc Araf Lyn Krt7 Frs2 Frs3 Phlpp1 Tfrc Actb Pik3c2b Actr2 Actr3 Arhgap5 Prkci Arap1 Kirrel1 Zdhhc5 Tln1 Rin1 Pfn1 S100a10 Snca Arhgef5 Hnrnpr Sdc4 Sdc3 Dyrk1b Insr Cltc Pitpna Stam Nfkb1 Flot1 Atp5f1c Errfi1 Usp6nl Myo6 Slc5a5 Snx5 Tollip Smu1 Vav1 Etl4 Vav2 Sdc1 Antxr1 Hip1 Arf4 Braf Adam17 Ptprr Clta Dcbld2 Ptprf Git1 Laptm4a Pak1 Cdv3 Plekha6 Caskin2 Cyld Anks1a Ahnak Git2 Mink1 Rplp0 Actn1 Mpzl1 Snx33 Map2k1 Actn4 Tkt Nedd9 Baiap2l1 Plscr1 Gprc5a Rbck1 Mapk8 Htt Aldoa Map2k7 Appl2 Stx4 Rps2 Limd1 Sdcbp Cstb Inppl1 Krt18 Pygb Gsn Pdzd11 Krt17 Ap2s1 Mcf2 Racgap1 Rela Eps15l1 Esyt1 Dok1 Eppk1 Dok2 Cttn Axl Ctnnd1 Flnb Ensa Stat2 Raf1 Pkn2 Frk Hipk2 Tjp2 Map3k14 Hipk3 Eef1a2 Prp4k Grb14 Rictor Grb10 Phpt1 Stip1 Cdh3 Ptpra Cdh2 Plekhn1 Cavin1 Cavin2 Tom1 Cdk1 Cc2d1a C8h11orf52 Cfl1 Prkx Magi1 Hat1 Ddx3x Ap2a1 Pkp2 Acp1 Hnrnpdl Anxa4 Nck1 Ldlr Pkp3 Anxa1 Vcl Cysrt1 Adam9 Stambp Pld1 Map4k5 Pkm Lpp Lck Rab5a Pld2 Ppp1r14b Ywhaz Itga3 Pdgfrb Elmo2 Atp1a1 Abl2 Slc38a2 Dynll1 Ptpn6 Tom1l2 Efnb2 Ptpre Cav2 Cebpb Tnk2 Ripk1 Sirpa Ralgds Dlg3 Alb Bcl2 Crim1 Ddx6 Ptpn12 Pdlim1 Mapk14 S100a11l1 Arhgap35 Sh3bgrl Afap1l2 Ptk2b Rbm3 Tgif1 Sfpq Khdrbs1 Nck2 Dapp1 Iqgap1 Asap1 Slc12a7 Erbb2 Mt-co2 Baiap2 Sh3gl3 Eif4ebp1 Lsr Epha1 Prkaa1 Epha2 Prkaa2 Epn2 Epn1 Dyrk4 Epha4 Fyn Jak1 Rps6ka3 Itgb1 Nos3 Epn3 Dyrk3 Egfr Usp31 Elf3 Gsk3a Klf11 Cdk5 Aplp2 Myh9 Dsg2 Ctnnal1 Rps6ka2 Cd59b Tnip1 Wbp2 Socs1 Mvp Trim29 Eif4g1 Dock1 Ephb1 Cebpa Ephb3 Phldb2 Ptpn1 Jak2 Slitrk6 Sh3kbp1 Rgs16 Csk Kras Mta2 Arhgap32 Rps6ka1 Snrpd2 Kit Egf Tagln2 Prkca Spry2 Rbbp7 Spry1 Pten Reps2 Grb7 Ralbp1 Mtor Bcar3 Spry4 Pebp1 Ptpn23 Slc25a5 Hspe1 Arhgap42 Stat5a Zpr1 Stat5b Cdk2 Hras Elk1 Ptpn18 Pik3cg Casp9 Mapk9 Erbb3 Rpl30 Map3k3 ID%NETPATH%ID ID Psmd4 Elk4 Raf1 Fhl2 Map2k1 Elk3 Cdk2 Rb1 Rbl1 Id3 Hes1 Smurf2 Elk1 Tcf3 Myf5 Rbl2 Map2k2 Atf3 Smad3 Tcf7l2 Mapk1 Mapk3 IL9%NETPATH%IL9 IL9 Stat5a Stat5b Mapk1 Kat5 Stat6 Il9r Mapk3 IL3%NETPATH%IL3 IL3 Ppp2ca Map2k1 Foxo1 Csf2rb Ywhaz Lyn Gsk3b Ptpn6 Prkcb Crk Prkca Pik3r2 Dok1 Prkaca Socs3 Inpp5d Ywhab Fes Shc1 Nfkb1 Hras Ptprc Gab1 Bcl2l1 Gab2 Rack1 Socs2 Creb1 Bcl2l11 Kcnip3 Pik3cd Rxra Rara Slc2a1 Bad Crkl Pik3r1 Gata2 Ptk2 Mapk1 Atf1 Gsk3a IL5%NETPATH%IL5 IL5 Pik3cg Socs1 Dnm2 Unc119 Foxo3 Stat1 Bax Sos1 Stat3 Ywhaz Lyn Gsk3b Hck Sdcbp Map2k2 Rps6ka1 Cbl Nfkbia Grb2 Ptpn11 Mapk14 Ctnnb1 Ptk2b Stat5a Stat5b Raf1 Shc1 Nfkb1 Hras Jun Elk1 Syk Rack1 Hcls1 Crkl Alox5 Jak1 Atf2 Pla2g4a Il5 Sox4 Il5ra Gsk3a Prkcd IL4%NETPATH%IL4 IL4 Snd1 Il2rg Socs1 Rasa1 Cebpa Rps6kb1 Mapk8 Stat3 Jak2 Ptpn6 Cbl Cebpb Nfkbia Crebbp Irs2 Ikbkb Ptpn11 Mapk14 Inpp5d Shc1 Stam Nfkb1 Cd40 Chuk Mapk11 Elk1 Syk Pik3cd Akt1 Bad Jak1 Ptk2 Atf2 Mapk1 Plcg2 Spi1 Il13 Ets1 Il4 Prkcd Grk3 Cxcr4 Mapk3 Il13ra1 IL-7%NETPATH%IL-7 IL-7 Il2rg Il7 Map2k1 Foxo3 Stat1 Foxo1 Stat3 Gsk3b Map2k2 Il7r Irs2 Stat5a Stat5b Shc1 Stam Jak3 Irs1 Akt1 Bad Fyn Pik3r1 Cblb Mapk1 Gsk3a Mapk3 NOTCH%NETPATH%NOTCH Notch Ncstn Skp1 Aph1b Ncor2 Fhl1 Dll3 Dll4 Maml1 Rbx1 Ring1 Maml2 Stat3 Lef1 Furin Jak2 Ccn3 Skp2 Src Jag2 Gsk3b Hes6 Maml3 Cirsr Notch4 Yy1 Psenen Notch2 Lfng Psen2 Rela Smad1 Hdac2 Nfkb1 Hes1 Tcf3 Akt1 Snw1 Pik3r1 Smad3 App Mapk1 Cul1 Mapk3 IL2%NETPATH%IL2 IL2 Map2k1 Foxo3 Mapk8 Map2k2 Crk Pik3r2 Rela Mtor Socs3 Stat5a Raf1 Stat5b Shc1 Cdk2 Sgk1 Elk1 Creb1 Akt1 Crkl Pik3r1 Atf2 Ccne1 Mapk1 Ets1 Mapk3 Pik3cg Stam2 Il2rg Lck Sos1 Lyn Ptpn6 Cbl Il15 Irs2 Stat4 Il2ra Grb2 Ybx1 Hsp90aa1 Bcl2 Ets2 Ptpn11 Plcb1 Tert Mapk14 Nr3c1 Itm2b Eif3b Ptk2b Il2 Prkcz Nfkb1 Stam Nmi Jak3 Vil1 Pik3r3 Mknk1 Jun Irs1 Gab2 Vav1 Eif4ebp1 Pik3cb Pik3cd Fyn Jak1 Rps6 Eif4e TSLP%NETPATH%TSLP TSLP Stat5a Stat5b Map2k1 Nfkb1 Stat1 Nfkb2 Mapk8 Stat3 Stat6 Mapk9 Akt1 Nfkbia Mapk1 Stat4 Eif4e Rela Mapk14 Mapk3 RANKL%NETPATH%RANKL RANKL Mitf Nfkb1 Chuk Nfkb2 Traf3 Mapk8 Tnfsf11 Atp6v1e1 Sqstm1 Tnfrsf11b Trem2 Rel Traf2 Tab2 Traf6 Ptk2 Map3k7 Spi1 Mapk14 IL1%NETPATH%IL1 IL1 Elp1 Mapk8 Rel Tab2 Mapk9 Traf6 Pik3r2 Nfkbia Rela Ikbkb Map2k6 Dok1 Mapk14 Nfkb1 Rb1 Chuk Jun Map3k14 Map2k3 Ppp6c Tollip Peli1 Map3k2 Ube2v1 Ube2n Akt1 Irak4 Irak3 Pik3r1 Irak2 Atf2 Pla2g4a Irak1 Myd88 Sod1 Mapk1 Il1a Fbxw5 Il1b Peli2 Il1r2 Il1r1 Mapk3 Il1rn ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Ilvbl Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Rpia Gpi Taldo1 Tkt Hk2 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Dhfr Mthfd1l Tyms Mtr Mthfd2 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Galt Aldob Aldoc Aldoa Khk Hk2 Gale P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Atf1 Traf6 Srf Mef2d Elk1 Map3k7 Map2k6 Map3k4 Hspb1 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Mapk11 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Rac2 Akt1 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Pik3cb Nos3 Il10 Il11 Ikbkb Spi1 Cxcr1 Stat6 Il15 Irs1 Cxcr2 Stat4 Il13 Il18 Il2ra Irs2 Sla2 Mapk6 Elk3 Elk4 Pdpk1 Akt3 Myc Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Fos Il20ra Il23a Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Il5ra Sos1 Il6st Shc1 Il10rb Il3ra Il10ra Mtor Il2 Il4 Il6 Il5 Il7 Il9 Il6r Il21 Il12rb2 Il11ra1 Srf Il4r Mapk15 Elk1 Spic Il1a Stat5a Stat5b Stat3 Stat2 Stat1 Chuk Cdkn1a Mapkapk2 Cdkn1b Mknk2 Mknk1 Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Alad Qars1 Hmbs Fech Eprs1 Cpox Urod Ppox NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Cacna1g Cacna1c Epb41l2 Chrnb4 Clic6 Ppp1r1b Kcnk3 Chrnb3 Chrnb2 Epb41l1 Slc18a2 Adcy2 Drd2 Drd4 Ppp1ca Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 Chrna4 Gnb1 Flna Gnai1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system Per2 Per1 Per3 Cry1 Cry2 Clock Csnk1d Csnk1e Bmal1 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Pmvk Ggps1 Hmgcr Mvd Fdft1 Lss Fdps Sqle Hmgcs1 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Grin2a Shank1 Shank3 Grm2 Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc17a8 Slc1a6 Slc17a6 Vamp8 Vamp1 Gria4 Vamp3 Gria3 Vamp2 Snap29 Gria2 Snap25 Grik5 Snap23 Stx19 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Stx11 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccnd2 Ccnd3 Ccne1 Rpa3 Cinp P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Pik3cg Pik3cb Pik3cd Pik3c2b Pik3c2a Mapk12 Mapk13 Mapk14 Cdkn1a Hras Mapk11 Pdpk1 Pik3c3 Akt3 Akt2 Ccne1 Akt1 Ccng1 Ctnnb1 Kras Tp53 Tp73 Ppp2cb Rb1 Ppp2ca Pten Nras Pik3c2g Rbl1 Siah1 Cdk2 Pik3r5 Atm Tp63 Atr Pik3r1 Pik3r2 Pik3r3 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Prkcz Hrh1 Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Gng12 Itpr2 Itpr1 Plcg1 Prkcq Plcg2 Prkcg Gnb1 Prkch Prkci Prkcb Prkcd Prkce Prkca Plcb4 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Gna11 Grin2d Grin2c Grin2b Grin2a Prkaca Gnaq Grin1 Prkcb Itpr1 Prkar1b Prkx Grik5 Prkacb Grina Grm1 Plcb4 Grm5 Grik1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Txn1 Mapk9 Pla2g4a Jun Mapk8 Max Ddit3 Map2k3 Myc Bcl2 Elk1 Map2k6 Mapk12 Stat1 Mapk13 Mapk14 Eef2k Map2k4 Mef2c Mknk2 Mknk1 Mapk11 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Kcnk3 Adcy2 Gnao1 Adcy7 Prkar2a Prkaca Prkar2b Kcnk9 Htr1d Htr1f Gnai2 Htr1b Htr1a Gnb1 Gng11 Gnai3 Gnai1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Prkcz Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Plcg1 Prkcq Plcg2 Prkcg Gnb1 Prkch Oxtr Prkci Prkcb Prkcd Prkce Prkca Plcb4 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Gng10 Adcy2 Gng3 Adcy7 Gng5 Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Htr4 Gnb3 Gnal Gnb5 Gng12 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Prkar1b Cacna1g Prkacb Adcy2 Gnao1 Adcy7 Prkar2a Prkaca Prkar2b Gnb1 Gng11 Gnai3 Gnai1 Cacna1a Cacna1b Gabbr1 Gabbr2 Adcy4 Adcy1 Adcy8 Adcy5 Adcy6 Kcnj3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Ube2t Ube2s Ube2v2 Ube2k Uba6 Ube2d2b Ube2n Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2d2 Ube2e3 Uba3 Ube2d1 Ube2e2 Ube2g2 Ube2l6 Ube2g1 Ube2a Atg7 Sae1 Ube2l3 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway App Erbb4 Apbb3 Nectin1 Trpc6 Afdn Trpc5 Trpc7 Cdh3 Kat5 Wnt5a Trpc1 Cdh1 Trpc4 Wnt5b Wnt9a Kat7 Wnt9b Wnt10a Bace2 Bace1 Ctnnb1 Wnt10b Acta1 Actb Gsk3b Notch4 Actr2 Ern1 Psenen Notch1 Notch2 Notch3 Psen1 Wnt8b Psen2 Wnt8a Fstl1 Wnt16 Lef1 Wnt11 Ncstn Aph1b Lrp1 Lrp6 Lrp2 Lrp3 Lrp4 Lrp5 Wnt6 Rbpjl Wnt7b Wnt3a Dvl1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Cd44 Actg1 Actg2 Wnt3 Tcf7l2 Fzd1 Actbl2 Actc1 Fzd2 Jup Fzd5 Trim3 Fzd4 Fzd6 Fzd9 Fzd8 Wnt2b 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh1b1 Maoa Aldh1a2 Aldh1a1 Maob Aldh3a2 Aldh2 Aldh3a1 Aldh1a3 Aldh16a1 Aldh8a1 Aldh7a1 Aldh9a1 Aldh1l2 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Tp73 Mdm2 Mdm4 Tp63 Tp53 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Ilvbl Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss2 Acss3 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Pank3 Pank4 Pank1 Dcakd METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Ireb2 Aco1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Vav1 Vav2 Map3k3 Map3k2 Blnk Btk Cd79b Pik3cg Ptpn6 Pik3cb Lyn Pik3cd Ptprc Ppp3ca Ppp3cb Nfkbia Grb2 Mapk10 Map2k2 Map2k1 Hras Ikbkb Fos Sos1 Mapk12 Mapk13 Chuk Mapk14 Itpr3 Itpr2 Itpr1 Mapk11 Mapk1 Mapk9 Jun Mapk8 Mapk3 Rac2 Rac1 Araf Plcg2 Nras Prkcb Prkcd Nfkbil1 Raf1 Cd22 Vav3 Syk P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Akt3 Akt2 Akt1 Eif4ebp1 Tp53 Tsc2 Tp73 Ppp2cb Tsc1 Igbp1 Ppp2ca Prkaa1 Prkab2 Rps6kb1 Prkaa2 Prkab1 Prkag1 Tp63 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Plcb3 Plcb2 Plcb1 Dagla Lpl Pla1a MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Pmm1 Mpi Gmppa Pmm2 Gmds Gmppb MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrnp40 Zrsr2 Prpf3 Snrpb2 Snrpa HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Txn1 Hif1a Akt3 Rorc Arnt Akt2 Txn2 Crebbp Akt1 Egln2 Egln3 Vhl Mtor THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Psmc3ip Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Tbp Brf1 Tbpl2 Tbpl1 Creb5 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Polr2sl1 Taf8 Taf7 Taf6 Gtf2e1 Taf2 Prkar1b Prkar2a Crebbp Prkar2b Gtf2a1l Polr2c Taf1c Taf9 Creb3l3 Creb3l4 Polr2h Polr2e Creb3l1 Ttf2 Creb3l2 Polr2f Ttf1 Taf9b Taf11 Gtf2h1 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Gng10 Adcy2 Gnao1 Gng3 Adcy7 Gng5 Gng7 Gnai2 Gng8 Gngt2 Gnb1 Gnb2 Gnai3 Gnb4 Gnai1 Gnb3 Oprd1 Gnb5 Pomc Gng12 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b2 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Avp Oxt GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 UNTITLED%PANTHER PATHWAY%P00019 untitled Prkcz Nos3 Map2k2 Map2k1 Akt3 Akt2 Plcb4 Plcb3 Gna11 Gna14 Plcb2 Plcb1 Gnaq Itpr3 Itpr2 Itpr1 Prkar1b Prkacb Ednrb Ednra Mapk1 Pla2g4a Adcy3 Edn1 Edn2 Edn3 Adcy10 Adcy2 Gucy1b1 Mapk3 Prkg2 Gucy1a1 Adcy7 Gucy1a2 Akt1 Prkaca Prkar2a Prkar2b Araf Prkcq Prkcg Prkch Prkci Prkcb Gnal Prkcd Adcy4 Prkce Adcy1 Prkca Adcy8 Raf1 Adcy5 Adcy6 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Dhfr Gch1 Tyms 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Prkcz Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Htr2a Htr2c Plcg1 Htr2b Prkcq Plcg2 Prkcg Gnb1 Gng11 Prkch Prkci Prkcb Prkcd Prkce Prkca Plcb4 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Flnb Tln1 Vcl Vasp Pxn Col17a1 Col13a1 Itga7 Pik3cg Fn1 Itga8 Pik3cb Arl1 Pik3cd Itga5 Itga6 Itga9 Pik3c2b Itga3 Pik3c2a Itga4 Ptk2 Elmo2 Map2k2 Itga1 Elmo1 Map2k1 Itga2 Hras Itga10 Col4a3 Arpc3 Col4a1 Cav1 Arpc2 Col4a2 Col8a1 Col4a5 Arpc5 Parvb Parva Rap2b Col16a1 Arf1 Mapk6 Col12a1 Itgax Ilk Itgav Rnd2 Rhoc Rnd3 Rhoa Rnd1 Rhob Itgam Asap1 Itgal Actb Arhgap10 Rap1a Col3a1 Rap1b Itgad Itgb8 Itgb6 Itgb7 Sos1 Itgb1 Shc1 Itga2b Itgb4 Rras Actn2 Itgb2 Actn1 Actn4 Crk Arf6 Arhgap26 Col15a1 Col11a1 Col11a2 Src Dock1 Bcar1 Dnajc27 Lamb2 Lamb3 Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Col6a2 Ptk2b Actg1 Lims2 Lamc3 Lamc1 Actbl2 Flna Map3k3 Map3k2 Mapk10 Map3k4 Mapk13 Map2k4 Mapk9 Mapk8 Braf Pik3c3 Map2k3 Mapk3 Rac2 Rac1 Araf Col14a1 Itgbl1 Crkl Arfgap1 Col1a2 Col5a2 Nras Col5a3 Col5a1 Dmbt1 Col9a2 Col9a1 Arpc1b Lama5 Arpc1a Raf1 Lama1 Pik3r1 Lama2 Pik3r2 Lama4 Pik3r3 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Arhgap8 Shc2 Pik3cg Pik3cb Pik3cd Map2k2 Map2k1 Hras Ikbkb Stat6 Stat4 Mapk6 Elk4 Pdpk1 Myc Akt2 Jak3 Fos Arhgap10 Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Shc1 Arhgap26 Mapk15 Stat5a Stat5b Stat3 Stat2 Stat1 Chuk Ehf Srgap1 Srgap3 Rab11b Arhgap5 Arhgap4 Erf Erg Arhgap9 Shc3 Rasa2 Rasa1 Pdgfrb Pdgfra Pdgfa Pdgfrl Pdgfb Grap Fli1 Rps6kc1 Fev Gabpa Nck2 Jak2 Jak1 Nck1 Arhgap15 Arhgap12 Gab1 Gab2 Etv3 Spdef Elf1 Elf2 Gsk3a Elf3 Elf4 Elf5 Ophn1 Usf2 Vav3 Grap2 Elp1 Vav1 Rerg Vav2 Nin Pkn2 Map3k2 Ninl Arhgap42 Grb2 Mapk10 Rps6kb1 Pik3r5 Srf Elk1 Map3k4 Mapkapk2 Itpr3 Rps6ka5 Itpr2 Mknk2 Itpr1 Mknk1 Mapk1 Jun Mapk8 Braf Ets1 Pik3c3 Mapk3 Plcg1 Araf Plcg2 Nras Arhgap1 Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Slc44a3 Actr1a Myo3b Chrnb1 Myo7a Slc18a3 Myo7b Slc6a8 Chrna10 Myh2 Myh3 Myh8 Myh9 Myh4 Myh6 Myh7 Myo1c Myo1b Myo1e Myo1d Myo5c Myo5b Myo1a Myh11 Myo1g Myo1f Plekhh3 Myh10 Myh7b Myo6 Myo18b Myo5a Myo9a Slc5a7 Chrnd Chrne Chrng Chrna2 Chrna1 Myo10 Chrna9 Acta1 Myo15a Actb Myo16 Myo19 Actg1 Actg2 Actbl2 Actc1 Chrnb4 Chrnb3 Chrnb2 Chrna3 Chrna6 Chrna5 Chrna4 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Stat6 Jak3 Stat5a Stat5b Stat4 Stat3 Jak2 Jak1 Stat1 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Phgdh Psph Psat1 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Vasp Pik3cg Pik3cb Pik3cd Pik3c2b Pik3c2a Rac2 Rac1 Plcg1 Plcg2 Ntn1 Ntn3 Nfatc4 Nfatc3 Nfatc2 Ablim1 Dcc Pik3r5 Ntng1 Unc5b Unc5d Unc5c Pik3r1 Pik3r2 Pik3r3 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc6a15 Slc6a20a Slc6a16 Slc18a1 Slc6a2 Slc18a2 Slc6a3 Slc6a19 Slc6a18 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Ugt2b7 Fmo3 Cyp2a3 Ugt1a2 Ugt1a3 Inmt Ugt1a5 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mat2a Mtr Mat1a CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Myo3b Myh2 Myh3 Myh8 Myh9 Myh4 Myh6 Myh7 Arpc3 Arpc2 Myh11 Arpc5 Myh10 Myh7b Rhoc Acta1 Actb Diaph2 Diaph1 Tubb2b Tubb2a Cfl1 Actg1 Cfl2 Actg2 Mylk2 Pfn1 Mylk3 Pfn3 Actbl2 Pfn2 Actc1 Stmn1 Pak1 Pak6 Stmn4 Pak3 Pak2 Pak5 Pak4 Tubb5 Tubb6 Tubb3 Mylk Limk1 Arpc4 Rock2 Rac2 Tubb4b Rock1 Rac1 Arpc1b Arpc1a INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Elk1 Map2k2 Map2k1 Rps6kb1 Rps6ka5 Irs1 Mapk1 Irs2 Rasa1 Map2k3 Mapk3 Ins2 Insr Igf2r Fos Igf2 Igf1 Insrr Rps6ka3 Igf1r Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Raf1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Ifngr2 Ifng Ifngr1 Jak2 Jak1 Stat1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Uckl1 Upp1 Upp2 Uprt Nme3 Nme2 Nme4 Uck1 Uck2 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Cacna1e Grm4 Grm7 Grm6 Grm8 Vti1a Grin2a Slc17a7 Stx1b Cacnb1 Slc1a1 Stx1a Slc1a3 Slc1a2 Grin1 Slc1a7 Slc1a6 Vamp8 Vamp1 Gria4 Vamp3 Gria3 Vamp2 Snap29 Gria2 Snap25 Grik5 Snap23 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkar1b Prkx Prkacb Grm1 Grm5 Adcy10 Prkaca Prkar2a Prkar2b Gnai2 Gnb1 Gnai3 Gnai1 Cacna1a Cacna1b APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Pik3cg Pik3cb Pik3cd Casp9 Atf2 Birc3 Nfkbia Eif2ak2 Birc2 Mapk10 Tnf Madd Bcl2l11 Tnfrsf1b Tnfrsf1a Tradd Ikbkb Nfkb2 Nfkb1 Traf2 Cycs Bcl2l1 Xiap Endog Tnfsf10 Rela Map3k1 Apaf1 Tnfrsf10b Lta Fadd Atf7 Ltb Atf6 Akt3 Atf4 Atf3 Akt2 Jdp2 Aifm1 Map2k7 Gzmf Map4k3 Fos Atf6b Cradd Tp53 Bak1 Eif2s1 Casp8 Casp7 Prkra Casp3 Bik Ripk1 Map4k2 Diablo Bax Rel Fas Faslg Daxx Map3k14 Atf1 Chuk Map2k4 Mapk1 Mapk9 Jun Mapk8 Map2k3 Mapk3 Bcl2 Akt1 Igf2r Prkcq Prkcg Prkch Prkcb Prkcd Prkce Prkca LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Pik3cg Pik3cb Pik3cd Atf2 Grb2 Mapk10 Map2k2 Map2k1 Hras Map3k1 Pdpk1 Akt3 Rhoc Rhoa Map2k7 Rhob Kras Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Shc1 Tiam1 Ralgdsl1 Rala Ralb Exoc2 Pld1 Pld2 Ralgds Srf Elk1 Map2k6 Map3k4 Stat3 Mapk12 Mapkapk3 Stat1 Mapk13 Mapk14 Mapkapk2 Map2k4 Pak1 Mapk11 Pak3 Pak2 Mapk1 Mapk9 Jun Mapk8 Braf Ets1 Pik3c3 Map2k3 Mapk3 Rac2 Akt1 Rac1 Araf Nras Gsk3a Raf1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Plcb3 Gng10 Plcb2 Plcb1 Grk3 Grk2 Elk1 Gng3 Agtr1a Arrb2 Arrb1 Gng7 Egr1 Gnaq Agt Gng8 Gngt2 Map2k2 Map2k1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Itpr1 Mapk1 Mapk3 Gnb1 Gng11 Prkca Raf1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Brf1 Tbpl1 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 Taf6 Gtf2e1 Taf2 Gtf2a1l Polr2c Taf1c Taf9 Polr2h Polr2f Ttf1 Taf9b Taf11 Gtf2h1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Gadd45g Sumo2 Chek2 Sumo3 Cdkn1a Gadd45b Gadd45a Hdac1 Sfn Cdkn2a Traf2 Mta2 Ccnb1 Gtse1 Cdk1 Sirt1 Cdc25c Pdpk1 Akt3 Akt2 Ccne1 Akt1 Crebbp Tp53 Tp73 Mdm2 Mdm4 Pten Cdk2 Atm Tp63 Atr THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Cacna1e Prkcz Cacnb1 Vamp8 Vamp1 Vamp3 Vamp2 Snap29 Snap25 Snap23 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Trh Trhr Stx3 Cga Cacnb3 Cacnb4 Cacnb2 Tshb Plcg1 Prkcq Plcg2 Prkcg Gnb1 Prkch Prkci Prkcb Cacna1a Cacna1b Prkcd Prkce Prkca ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b7 Hsd17b6 Soat2 Hsd17b3 Soat1 Hsd17b1 Hsd17b2 Lipa Cyp19a1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10a Wnt10b Acta1 Actb Actr2 Wnt8b Wnt8a Fstl1 Wnt16 Lef1 Wnt11 Wnt6 Wnt7b Wnt3a Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Actg1 Actg2 Wnt3 Tcf7l2 Fzd1 Actbl2 Actc1 Fzd2 Fzd5 Fzd4 Fzd6 Fzd9 Fzd8 Wnt2b Pcdhb2 Pcdhb1 Cdh9 Pcdhb3 Cdh8 Cdh7 Pcdhb5 Cdh6 Cdh5 Pcdhgb7 Pcdh10 Pcdhgb2 Cdh2 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdhgc3 Pcdhb17 Pcdhb19 Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac2 Cdhr2 Pcdha13 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ctnnb1 Ptpn1 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Ctnnd2 Pcdhga2 Ctnnd1 Pcdhga3 UNTITLED%PANTHER PATHWAY%P06664 untitled Tgif1 Skil Rela PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Suclg1 Mdh1 Ogdh Aco2 Sdhc Pdk2 Cs Fh Pdha2 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Odc1 Azin1 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Upb1 Dpysl5 Nt5e Aldh6a1 Dpys Dpyd Dpysl2 Dpysl3 Abat Cda ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Gng10 Adcy2 Gng3 Adcy7 Prkar2a Prkaca Gng5 Prkar2b Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnal Gnb5 Adrb1 Gng12 Prkx Prkacb INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Irs2 Pdpk1 Foxo3 Ins2 Insr Igf2r Igf2 Igf1 Tsc2 Gsk3b Insrr Tsc1 Mdm2 Igf1r Mdm4 Pten Gsk3a Foxo1 Irs1 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Gng10 Adcy2 Gng3 Adcy7 Prkar2a Prkaca Gng5 Prkar2b Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnal Gnb5 Gng12 Hrh2 Prkx Prkacb BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gng10 Adcy2 Gng3 Adcy7 Gng5 Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnal Gnb5 Gng12 Adrb3 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Nt5e Ampd3 Gda Xdh METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Crhr1 Gna11 Gng10 Gna14 Gng3 Gng5 Gng7 Gnaq Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnal Gnb5 Pomc Gng12 Crh Crhr2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Aph1b Pkn2 Prkcz Mapk15 Cacnb1 Mapk12 Mapk10 Mapk13 Mapk14 App Cacna1c Mapk11 Mapk1 Mapk9 Cacna1f Kat5 Cacna1d Mapk6 Mapk8 Klc1 Cacnb2 Adam17 Mapk4 Klc4 Mapk3 Klc3 Klc2 Apba1 Apba2 Bace2 Apba3 Bace1 Pkn1 Prkcq Prkcg Prkch Psenen Prkci Prkcb Psen1 Prkcd Psen2 Prkce Prkca Ncstn CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Rhoc Rac2 Rac1 Cxcl12 Slit1 Slit2 Slit3 Robo1 Ntn1 Cxcr4 Ntn3 Abl1 Srgap1 Dcc Ntng1 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Dscaml1 Dhodh Cad Ctps2 Cps1 Ctps1 Nme3 Nme1 Nme2 Nme4 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Egfr Phldb2 Map3k3 Shc2 Nf1 Map3k2 Rras2 Dab2ip Pebp4 Pik3cg Spry2 Prkcz Spry1 Pik3cb Spry4 Pik3cd Pebp1 Pik3c2b Pik3c2a Mapk10 Map2k2 Map2k1 Hras Stat6 Erbb4 Stat4 Akt3 Akt2 Map2k7 Sos1 Shc1 Pik3r5 Rras Map2k6 Stat5a Map3k4 Stat5b Stat3 Mapk12 Stat2 Stat1 Mapk13 Mapk14 Map2k4 Mapk11 Prkd3 Shc3 Mapk1 Rasa2 Mapk9 Rasa1 Prkd1 Mapk8 Braf Prkd2 Pik3c3 Map2k3 Mapk3 Grap Rac2 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Gab1 Prkch Gab2 Prkci Nras Prkcb Prkcd Prkce Prkca Erbb2 Raf1 Erbb3 Mras Rasal2 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Fgb Fga Mmp13 Mmp1 Mmp3 Fgg Plat Plg Mmp9 Plau Serpinf2 Serpine1 Serpinb2 PNAT%PANTHER PATHWAY%P05912 PNAT Slc6a3 Gng3 Gng8 Vamp8 Gnb2 Vamp1 Gnb4 Gnb3 Vamp3 Epb41l3 Vamp2 Drd1 Snap29 Drd5 Ppp1cc Snap25 Gnaz Prkx Prkacb Snap23 Epb41l2 Clic6 Stx3 Ppp1r1b Kcnk3 Epb41l1 Slc18a2 Adcy2 Drd2 Drd4 Adcy7 Ppp1ca Prkar2a Prkaca Prkar2b Kcnk9 Epb41 Gnai2 Gnb1 Gng11 Flna Gnai3 Gnai1 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Stk36 Fbxw11 Gli1 Btrc Crebbp Shh Smo Ptch1 Sufu MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Gng10 Gng3 Gng5 Slc18a3 Gng7 Slc6a8 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkar1b Prkx Prkacb Kcnj9 Adcy10 Kcnj6 Kcnj5 Slc5a7 Chrm2 Gnao1 Chrm4 Gnat2 Prkar2a Prkaca Gnat1 Prkar2b Gnai2 Gnb1 Gng11 Gnai3 Gnai1 Kcnj3 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Gfpt1 Gfpt2 Amdhd2 Gnpda2 Npl TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Atf2 Mapk10 Hras Crebbp Bmp10 Bmp8a Bmp15 Dcp1b Lefty2 Acvr1 Foxh1 Smurf2 Smurf1 Jund Acvr1c Snip1 Rras Skil Lefty1 Tgfb2 Tgfb3 Gdnf Cited1 Acvrl1 Cited2 Acvr1b Amhr2 Fosl1 Mstn Gdf2 Bmpr1a Gdf3 Gdf6 Bmp7 Map3k7 Bmp6 Bmp5 Gdf7 Bmp4 Mapk12 Bmpr2 Smad1 Mapk13 Bmp3 Mapk14 Smad2 Gdf9 Nodal Bmp2 Smad3 Smad4 Bmp1 Smad9 Acvr2a Tll2 Gdf15 Inhba Inhbb Mapk11 Acvr2b Junb Mapk1 Inhbc Mapk9 Tgfbr1 Jun Smad5 Mapk8 Tgfbr2 Smad6 Inhbe Smad7 Mapk3 Gdf11 Gdf10 Nras BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation Fgb Fga Fgg Plat Plg Plau F2r Kng2l1 Klkb1 Gp5 Proc Gp9 Gp1bb F13b Gp1ba Procr Vwf F10 F12 Proz Tfpi F2 Itga2b Serpina10 F3 Thbd F7 F8 F9 Pros1 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Ptger1 Gna11 Foxo4 Gngt1 Gna14 Ywhaz Pik3cb Casp9 Nos3 Gnaq Gngt2 Gnb2 Gnb4 Gnb3 Rps6kb1 Gnb5 Foxo1 Irs1 Pdpk1 Akt3 Akt2 Gnat2 Akt1 Foxo3 Insr Gnai2 Gsk3b Gnb1 Gnai3 Gnai1 Nras Sos1 Pik3r5 Pik3r1 Pik3r2 Pik3r3 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Grm4 Grm7 Grm6 Grm8 Drd1 Drd5 Kcnj9 Kcnj6 Kcnj5 Chrm2 Chrm4 Rap1a Gsk3b Rap1b Adcy2 Drd2 Drd4 Prkaca Gnb1 Gnai1 Gsk3a Gngt1 Adora2b Adora2a Adra2c Adra2b Htr6 Htr7 Grm2 Oprl1 Phka1 Phka2 Adrb2 Adra1b Adra1a Adra1d Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Oprm1 Htr5a Phkb Chrm1 Chrm3 Chrm5 Hrh4 Hrh3 Adora1 Gnrhr Gys1 Gys2 Clta Cltb Cltc Mtnr1a Creb1 Creb3 Phkg1 Phkg2 Crebbp Mtnr1b Pygb Pygl Pygm Gpr50 Oprk1 Creb3l3 Creb3l4 Creb3l1 Creb3l2 Gng10 Hrh1 Gng3 Creb5 Gng5 Gng7 Gng8 Gngt2 Gnb2 Oprd1 Adrb1 Gng12 Hrh2 Adrb3 Prkar1b Prkacb Grm1 Grm5 Adcy3 Adcy7 Prkar2a Prkar2b Htr2a Htr1d Htr2c Htr1f Htr2b Gnai2 Htr1b Htr1a Gnai3 Htr4 Gnal Adcy4 Adcy1 Adcy8 Adcy5 Adcy6 Kcnj3 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Map3k3 Map3k2 Pik3cg Spry2 Ptpn6 Prkcz Spry1 Pik3cb Spry4 Pik3cd Pebp1 Pik3c2b Pik3c2a Mapk10 Map2k2 Map2k1 Hras Akt3 Akt2 Map2k7 Map3k6 Frs2 Frs3 Fgfr3 Fgfr4 Fgfr1 Sos1 Fgfr2 Shc1 Map2k6 Map3k4 Mapk12 Mapk13 Mapk14 Map2k4 Mapk11 Shc3 Mapk1 Rasa2 Mapk9 Rasa1 Mapk8 Pik3c3 Map2k3 Mapk3 Grap Rac2 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Prkcd Prkce Prkca Raf1 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Cad Asl Nags Cps1 Ass1 Otc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Calml3 Rgs9 Gng10 Gngt1 Cngb1 Pde6a Pde6b Cngb3 Rcvrn Gng13 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb5 Gng12 Gnat1 Gnb1 Cnga3 Pdc Cnga1 Grk1 Rho ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Ywhaz Pld2 Slc6a3 Psma4 Mapk15 Psma3 Elk1 Psma6 Psma5 Ccne2 Psma2 Psma1 Mapk12 Mapk10 Cask Ywhah Ywhag Mapk14 Ywhae Th Ywhab Sfn Psmb10 Sncaip Psmb7 Prkn Psmb1 Gpr37l1 Septin5 Psmb3 Stx7 Septin2 Septin1 Mapk1 Gpr37 Mapk9 Stx12 Ndufv2 Mapk8 Psma7 Snca Mapk3 Ccne1 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Gna11 Gng10 Pkn2 Gna14 Grin2a Prkcz Gng3 Gng5 Slc18a3 Gng7 Gnaq Grin1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Chrm1 Itpr1 Chrm3 Grin2d Grin2c Grin2b Slc5a7 Pkn1 Prkcq Prkcg Gnb1 Gng11 Prkch Prkci Prkcb Prkcd Prkce Prkca Plcb4 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Gng10 Pdyn Penk Adcy2 Gng3 Adcy7 Gng5 Gng7 Gnai2 Gng8 Gngt2 Gnb1 Gnb2 Gnai3 Gnb4 Gnai1 Gnb3 Oprd1 Gnb5 Gng12 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rfc2 H3f3a Rpa2 Top2a Top1 Dna2 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Mcee Pccb DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Ppat Nme6 Guk1 Gart Dscaml1 Adsl Rrm2 Impdh2 Rrm2b Gmps Ak3 Nme3 Ak2 Nme1 Nme2 Ak4 Nme4 Adss2 Atic Nme7 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway F13b Rxra Vdr Rara Gc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Cacna1e Grm4 Gngt1 Grm7 Adora2b Grm6 Adora2a Grm8 Prkcz Rap1gap Grm2 Rasgrp3 Oprl1 Rasgrp4 Rasgrp1 Rasgrp2 Arhgef1 Bdkrb2 Bdkrb1 Gpr45 Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Oprm1 Drd1 Chrm1 Drd5 Chrm3 Chrm5 Adora1 Gnrhr Clta Cltb Cltc Chrm2 Chrm4 Rhoa Oprk1 Rap1a Rap1b Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Gng13 Dnajc27 Gng3 Gng5 Gng7 Gnaq Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Oprd1 Itpr3 Gng12 Itpr2 Itpr1 Grm1 Grm5 Drd2 Gnao1 Drd4 Prkcq Prkcg Gnb1 Prkch Prkci Prkcb Cacna1a Cacna1b Prkcd Prkce Prkca ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Grb14 Map2k1 Fgf1 Hras Dok1 Dok2 Dok3 Axin1 Grb7 Pdgfc Tcf7 Efnb1 Jag2 Efnb2 Jag1 Map3k1 Pla2g4d Angpt1 Apc2 Epha3 Wnt5a Ephb1 Ephb2 Dll1 Ephb3 Akt3 Wnt5b Dll3 Rhoc Dll4 Akt2 Dlk1 Rhoa Apc Wnt10a Tek Rhob Wnt10b Fos Gsk3b Notch4 Notch1 Notch2 Sos1 Shc1 Crk Pld1 Pld2 Src Rbpjl Wnt7b Dvl1 Dvl3 Wnt7a Stat3 Wnt2 Stat1 Wnt1 Tcf7l2 Fzd1 Fzd2 Fzd5 Rasa1 Pdgfrb Wnt2b Pdgfra Pdgfa Pdgfb Grap F2r Nck2 Jak1 Nck1 Ctnnb1 Frs2 Frs3 Fgfr1 Hspb1 Mapkapk3 Mapk14 Mapkapk2 Map2k4 Pak1 Prr5 Pak3 Prkd3 Pak2 Mapk1 Pla2g4a Prkd1 Jun Mapk8 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Akt1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Crkl Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Dscaml1 Rrm2 Rrm2b Dtymk Nme3 Nme1 Tyms Nme2 Nme4 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Stx1b Stx1a Syt5 Syt3 Syt2 Syt1 Syt11 Syt12 Syt7 Vamp1 Syt6 Unc13c Rab3a Stxbp1 Unc13b Syt15 Stx2 Snap25 Unc13d GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Pxn Pik3cb Atf2 Ptk2 Mmp3 Map2k2 Map2k1 Plau Bcl2l1 Irs1 Elk4 Cdh1 Itgav Pdpk1 Rhoa Foxo3 Fos Gsk3b Rps6ka3 Rps6ka1 Casp3 Sos1 Itgb1 Shc1 Bax Nr2c2 Clu Ier3 Rps6 Map3k14 Sp1 Crk Sp3 Elavl1 Akt1s1 Yes1 Snai1 Tcf4 Src Hbegf Nos1 Bcar1 Hdac7 Akap1 Cckbr Arrb2 Pparg Egr1 Gucy2e Arhgef28 Stat3 Cd38 Ptgs2 Camk4 Map2k5 Ptpn11 Ptk2b Tpcn1 Bad Cck Gast Map3k11 Slc18a2 Prkaca Jak2 Gnb1 Lyn Ppp3ca Nfkbia Grb2 Mapk10 Eif4ebp1 Rps6kb1 Creb1 Ctnnb1 Nfatc2 Traf6 Srf Odc1 Mef2d Elk1 Map2k6 Hspb1 Mapk14 Ywhab Eif4e Map2k4 Mef2c Foxo1 Itpr1 Pak1 Prkacb Mapk1 Mapk9 Pla2g4a Prkd1 Jun Mapk8 Braf Prkd2 Mapk3 Bcl2 Akt1 Rock1 Rac1 Plcg1 Araf Prkcq Prkch Prkcb Prkcd Prkce Prkca Adcy1 Raf1 Pik3r1 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Tpi1l2 Pfkm Aldoa Gpi Pklr Eno1 Hk2 Bpgm Eno2 Pfkl Pkm Pgk1 Pgam2 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Ncor2 Cirsr Maml1 Numb Dll3 Dll4 Dlk1 Rbpjl Notch4 Notch1 Notch2 Notch3 Jag2 Jag1 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Csad Gad1 Aldh5a1 Gad2 Abat FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Casp9 Mapk10 Map2k4 Apaf1 Mapk9 Jun Fadd Mapk8 Faf1 Parp3 Parp2 Parp1 Cflar Lmnb1 Lmnb2 Casp8 Gsn Casp7 Casp6 Capg Casp3 Lmna Scin Dffb Fas Faslg Daxx INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Pik3cg Prkcz Pik3cb Pik3cd Arpc3 Ikbkb Nfkb2 Cxcr1 Arpc2 Cxcr2 Arpc5 Rela Col12a1 Pdpk1 Akt3 Rhoc Akt2 Rhoa Acta1 Itgal Actb Itgb7 Sos1 Jund Itgb1 Shc1 Rras Il2 Stat3 Chuk Col6a2 Ptk2b Actg1 Actg2 Actbl2 Actc1 Junb Adcy2 Grap Prkaca Jak2 Vwf Gnai1 Cxcr3 Cxcr5 Cxcl10 Fpr1 Fpr3 Ccr10 Ccr1 Xcr1 Ccrl2 Ltb4r2 Vav1 Rhog Ccr9 Ccr8 Ccr7 Ccr6 Ccr5 Myo3b Ccr4 Ccr3 Ccr2 Cx3cr1 Ifnar1 Camk2d Ccl11 Myh2 Ccl12 Myh3 Ccl7 Myh8 Camk2a Myh9 Ccl5 Myh4 Ccl4 Myh6 Ccl3 Myh7 Ccl2 Pf4 Prex1 Cx3cl1 Nfat5 Ccl22 Ccl20 Ccl21 Myh11 Myh10 Myh7b Kras Nfatc4 Nfatc3 Nfatc2 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Cask Plcz1 Plce1 Gnb3 Mylk2 Itpr3 Mylk3 Gng12 Itpr2 Itpr1 Prkx Pak1 Prkacb Pak6 Pak3 Pak2 Mapk1 Pak5 Pak4 Jun Mylk Mapk3 Arpc4 Gnao1 Rac2 Akt1 Rock1 Rac1 Plcg1 Araf Gnai2 Col14a1 Plcg2 Gnai3 Cxcr4 Ifng Nras Prkcb Arpc1b Prkce Arpc1a Raf1 Adcy5 Adcy6 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Prtfdc1 Gda Pnp Hprt1 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Rhog Grin2a Grin1 Grik5 Arpc5 Grik2 Hip1 Apaf1 Grik1 Bdnf Grik4 Ift57 Grik3 Dync1h1 Grin2d Dnal4 Cltb Grin2c Dctn1 Grin2b Rhoj Rhoq Dync1i2 Dync1i1 Ap2a2 Ap2a1 Map2k7 Crebbp Hap1 Hip1r Fos Kalrn Acta1 Htt Tp53 Actb Gapdhs Dync1li2 Tp73 Actr2 Dync2h1 Casp8 Dync1li1 Dnai2 Dynll1 Casp3 Dynll2 Capn9 Cyc1 Capn5 Capn7 Capn6 Capn1 Tp63 Capn3 Capn2 Dlg4 Sp1 Dnah5 Dnah8 Cyfip1 Capns1 Capns2 Capn11 Capn12 Tbp Tubb2b Tubb2a Actg1 Actg2 Map2k4 Actbl2 Actc1 Map3k10 Mapk9 Jun Tubb5 Tubb6 Tubb3 Rac2 Tubb4b Rac1 Arpc1b Arpc1a ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Acly Pc Pklr Me1 Clybl Pck1 Cs Pkm Pdha2 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Vav1 Vav2 Pik3cg Pik3cb Pik3cd Ptprc Ppp3ca Ppp3cb Nfkbia Map2k2 Map2k1 Hras Ikbkb Map3k1 Akt3 Akt2 Fos Sos1 Zap70 Cd28 Cd86 Cd80 Lck Chuk Lcp2 Cd3g Cd247 Cd3e Cd3d Ppp3cc Lat Itpr1 Pak1 Pak3 Pak2 Mapk1 Mapk9 Jun Mapk8 Braf Pik3c3 Mapk3 Akt1 Rac1 Nck2 Plcg1 Araf Nck1 Prkcq Nras Raf1 Pik3r1 Vav3 Pik3r2 Grap2 Pik3r3 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Traf6 Elk1 Map3k7 Nfkbia Map2k2 Chuk Mapk14 Map2k1 Ikbkb Map3k8 Ikbke Tbk1 Ticam2 Irak4 Ecsit Nfkbie Tollip Irak1 Mapk9 Tlr10 Jun Myd88 Mapk8 Tank Irf3 Tlr7 Map2k3 Tlr6 Mapk3 Tirap Tlr4 Tlr3 Tlr2 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Psat1 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Axin1 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10a Wnt10b Wnt8b Wnt8a Fstl1 Wnt16 Lef1 Wnt11 Lrp6 Lrp5 Wnt6 Wnt7b Wnt3a Arrb2 Dvl1 Arrb1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Hdac1 Wnt3 Tcf7l2 Fzd1 Fzd2 Fzd5 Fzd4 Fzd6 Fzd9 Fzd8 Wnt2b Pcdhb2 Pcdhb1 Cdh9 Pcdhb3 Cdh8 Cdh7 Pcdhb5 Cdh6 Cdh5 Pcdhgb7 Pcdh10 Pcdhgb2 Cdh2 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdhgc3 Pcdhb17 Ppp3ca Pcdhb19 Ppp3cb Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac2 Cdhr2 Pcdha13 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Crebbp Cdh12 Cdh11 Cdh10 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Pcdhga2 Pcdhga3 Ppp3cc Arr3 Smarce1 Srcap Tbl1x Prkcq Nlk Kremen2 Prkcg Kremen1 Prkch Siah2 Prkci Ino80 Csnk2a2 Prkcb Ep400 Hells Hltf Prkcd Csnk1a1 Ppp2r5d Prkce Smarcal1 Prkca Ppp2r5c Ppp2r5b Ppp2r5a Ankrd6 Ppp2r5e Chd1l Arid1a Pygo2 Pygo1 Tle4 Tle3 Tle2 Prkcz Tle1 Ctnna2 Ctnna1 Csnk1g3 Hdac3 Hdac2 Csnk1g2 Tbl1xr1 Smarcb1 Hdac8 Csnk2b Smarca2 Sag Smarca1 Smarca4 Smarca5 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd1 Smarcd3 Smarcd2 Smarcc2 Smarcc1 Fbxw11 Btrc Gsk3b Smad1 Smad4 Smad5 Gnb1 Csnk1d Csnk1e Ctnnb1 Ppp2cb Ppp2ca Nfatc4 Nfatc3 Siah1 Nfatc2 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Gng13 Plcb1 Gng3 Gng5 Gng7 Gnaq Gng8 Gnb2 Gnb4 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Ada Prtfdc1 Pnp Xdh Hprt1 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Cacna1e Gng10 Stx1b Grm2 Gng3 Cacnb1 Gng5 Stx1a Gng7 Gng8 Gngt2 Vamp8 Gnb2 Vamp1 Gnb4 Gnb3 Vamp3 Gnb5 Vamp2 Snap29 Prkar1b Snap25 Prkx Prkacb Snap23 Adcy10 Gnao1 Gnat2 Prkar2a Prkaca Prkar2b Gnai2 Gnb1 Gng11 Gnai3 Gnai1 Cacna1a Cacna1b UNTITLED%PANTHER PATHWAY%P05916 untitled Gng10 Pdyn Adcy2 Gnao1 Gng3 Adcy7 Gng5 Gng7 Gnai2 Gng8 Gngt2 Oprk1 Gnb1 Gnb2 Gnai3 Gnb4 Gnai1 Gnb3 Gnb5 Gng12 Avp Oxt AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Nrp1 Dpysl4 Plxnb1 Sema3a Sema4d Cdk5 Rhoa Fes Rac2 Crmp1 Rac1 Frk Fyn Dpysl2 Arhgef1 Dpysl5 Dpys Pak1 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Plcb3 Plcb2 Plcb1 Gnao1 Gng3 Gng5 Cnr1 Gng7 Gng8 Gngt2 Gnb1 Gng11 Gnb2 Gnai3 Gnb4 Gnai1 Gnb3 Cacna1a Cacna1b Cacna1g Grm1 Grm5 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Psmc3ip Tbp Tbpl2 Tbpl1 Rrn3 Polr1b Taf1a Taf1b Taf8 Cavin1 Taf1c Ubtf Ttf1 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Cda BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Gng10 Adcy2 Gng3 Adcy7 Prkar2a Prkaca Gng5 Prkar2b Gng7 Adrb2 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnal Gnb5 Gng12 Prkx Prkacb ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Oprd1 Gnb5 Oprm1 Gng12 Prkx Prkacb Pdyn Adcy2 Creb1 Penk Gnao1 Adcy7 Prkar2a Prkaca Prkar2b Gnai2 Gnb1 Gnai3 Gnai1 Gnal ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Plcb3 Gna11 Plcb2 Adra2c Adra2b Plcb1 Adra1b Adra1a Plce1 Prkcg Prkcd Itpr1 Prkce Prkca Plcb4 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Ace Ren Agt ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Egln3 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc2a1 Nme2 Lalba CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Ikbkb Cd40 Mapk14 Traf3 Traf6 Elp1 Ikbkg Nfkbia Map3k1 Cd40lg Dusp1 Nfkb1 Chuk INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Pik3r4 Plcb4 Itpka Miox Ptpmt1 Inpp4a Pikfyve Ipmk Impa1 Mtor Isyna1 Vac14 Becn1 Sacm1l Inpp1 Pik3cb TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Ace Ren Agt STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Amy1 Ugp2 Ugdh Pgm1 Gpi Gusb Pgm2l1 Gys1 Gaa Agl Pygl LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 L2hgdh D2hgdh GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Gusb Ugt8 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Ptpn7 Cd3g Cd247 Elk1 Map2k7 Cd3d Calm2 Mapk3 Ubc Fyn Rac1 Ppp3ca Nfkbia Jun Map3k1 Ppp3cb Syk Nfkb1 Fos Rela Nfat5 Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Prkcb Plcg1 Prkca Mapk8 Shc1 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Abcc1 Ndufs3 Ndufs2 Ndufs7 Akr1a1 Xdh Cbr3 Akr1c3 Cbr1 Nqo1 Nos3 Abcb1a Abcg2 Ralbp1 Por CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Amt Cps1 Dld Gls2 Glud1 Hal Sds Aqp8 Asns Asrgl1 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Cacna1c Mapk3 Nfkbia Nfkb1 Rela Map2k1 Itpr1 Cacna1f Plcb1 Prkcb Cacna1d Mapk1 Raf1 Prkca Hras CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Itpr1 Plcb1 Prkca PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Pik3r4 Inpp5d Erbb2 Synj1 Inpp4b Pik3c2a Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 Plcb1 Pik3cd Pip4k2a Pikfyve Pik3r1 Vac14 Becn1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Mat2a Amd1 Srm Odc1 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Ace Ren Agt MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Ldhd Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Gmppa Pmm1 Mpi Sord Uxs1 Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Cmpk1 Tyms Rrm2b Slc28a3 Rrm2 Slc29a1 Ctps1 Slc28a1 Dck Nme1 Dctd PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Nqo1 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Pdia2 Snta1 Sdf2l1 Kcnj5 Ugt1a6a Kcnj4 Kcnh2 Hyou1 Pdia6 Chrm2 Pdia4 Kcnk1 Kcnq1 Dnajb11 Slc8a1 Cyp1a2 Adrb1 Ugt1a9 Erp29 Atp1b1 Ugt1a5 Cacnb1 Atp1b3 Ugt1a1 Comt Atp1b2 Hspa5 Kcna5 Ephx1 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Cyp2e1 Kcnj11 Abcc9 Cacna2d2 Cyp2c11 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc2a1 Nme2 Lalba PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Hsd17b10 Acat1 Hadh Echs1 Acadl Acss3 Acads Acaa2 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Sult1a1 Fmo1 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 Cyp2b2 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Qars1 Rpl18a Rps18l1 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Cyp3a73 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Rdh16 Dhrs9 Bco1 Cyp3a9 Rpe65 Cyp3a18 Cyp26a1 Dgat1 Retsat Lrat Pdia2 Sdf2l1 Hyou1 Aldh1a1 Pdia6 Pdia4 Dnajb11 Cyp2a3 Erp29 Ugt1a1 Hspa5 Cyp2b2 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Abcd1 Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Ace Ren Agt DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Tyr Dct PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Pfkm G6pc1 Gpi Eno1 Pgam2 Aldoa Hk2 Galm Tpi1l2 Pklr FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Gmppa Pmm1 Mpi Sord Uxs1 Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Ace Ren Agt INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Gng12 Gnb1 Ppp1ca Adcy2 Creb1 Gngt1 Fshr Prkacb Cga AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Ddc Th GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Ptpmt1 Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Cyp2d4 Ugt1a9 Slc22a1 Cyp2b2 Ugt2b7 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Npr1 Cry1 Clock Csnk1e Per1 CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Elk1 Calm2 Mapk3 Rac1 Ppp3ca Jun Map3k1 Ppp3cb Syk Fos Nfat5 Map2k1 Lck Grb2 Cd79b Raf1 Lyn Orai1 Blnk Hras Prkcb Plcg1 Prkca Mapk8 Shc1 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Gnaq Gnb1 Plcb1 Chrm1 Htr2c Gngt1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Eprs1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Farsa Farsb Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Ace Ren Agt GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Aldoa Hk2 Galm Pklr Pgk1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Cyp2e1 Sult1a1 Cyp2d4 Abcb1a Abcg2 Sult2a1 Abcc4 Abcc1 Abcc5 Gstp1 Ugt2b35 Gstt1 Pdia2 Sdf2l1 Ugt1a6a Hyou1 Pdia6 Pdia4 Dnajb11 Cyp1a2 Ugt1a9 Cyp2a3 Erp29 Ugt1a1 Hspa5 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Dbt Dld Bckdhb Sds Bckdha Pccb METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cyp2d4 Cbr1 Alox12 Prxl2b Cyp2u1 Cyp2c11 Alox5 Lta4h Ugt1a9 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Aars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Alox15b Ltc4s Tbxas1 Pla2g2a Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Mt-co1 Cycs Ndufa1 Mt-atp6 Uqcrc1 Atp5f1d Sdhd Atp5f1c Atp5pb Sdhc Sdhb Atp5mc2 Sdha Atp5f1b Atp5f1a Gpd2 Slc25a4 Slc37a4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Ggcx Vkorc1 Nqo1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Cyp1a2 Scn1b 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Btd Hlcs Acacb CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Ace Ren Agt OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Ugp2 G6pc1 B4galt1 Pgm1 Gale Glb1 Lct Gla Galt Gaa Akr1b1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Cyp2e1 Aldh3a1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Ip6k1 Inpp5j Itpka Inpp4a Ipmk Impa1 Isyna1 Inpp4b Itpk1 Ippk Bpnt1 Nudt3 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Hmgcl Oxct1 Acat1 Hadh Echs1 Acads CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Pmvk Acat1 Hmgcr Fdps Mvd Idi1 Hmgcs1 Fdft1 Lss Sqle BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Gpi Pkm Pfkp Tpi1l2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Pld2 Plpp1 Pisd Pcyt1a Pla2g15 Lypla1 Chat Dgka Chka Agpat1 Gpd2 Cdipt Ptpmt1 Pgs1 Gpam Gpd1 Cds1 Crls1 Pla2g2d Ptdss1 Ptdss2 Phospho1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway Cfp C8a Cfb C3 Cfd C5 C6 C7 C9 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Slc6a4 Cyp2d4 Cyp3a73 Cyp2c11 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Gla Sptlc1 Acer2 Cerk Sptlc2 Degs2 Enpp1 Samd8 B4galt2 Sphk2 Ugcg Ugt8 Sdr16c5 HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Sod3 Sod2 Sod1 Tyrp1 Cat NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Abcc1 Bche Ces2h Ces1d Top1 Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Abcb1a Hspa5 Abcg2 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Ace Ren Agt WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Gapdhs Bpgm Sdhd Sdhc Sdhb Sdha Cs Mdh1 Idh3g Mpc1 Fh Idh1 Idh3a Tktl1 H6pd Aco1 Pfkm Rpia Gpi Taldo1 Pdhx Aldoc Bckdhb Gls Acly Ogdh Pgk2 Slc16a1 Ireb2 Gsr Eno1 Pkm Glud1 Slc2a13 Cad PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Mapk3 Socs1 Irs1 Insr Map2k1 Ptpn6 Ghr Grb2 Plcg1 Mapk1 Stat5a Stat5b Raf1 Ins2 Rps6ka1 Prkca Slc2a4 Sos1 Hras Jak2 Shc1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Scnn1a Ren Scnn1b Scnn1g Ca1 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc14a2 Atp1b1 Atp1b3 Aqp3 Atp1b2 Aqp2 Atp6v1b1 Slc4a1 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd1 Gpd2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3r4 Pik3cd Ptpmt1 Prex1 Vac14 Inpp5f Plce1 Inppl1 Pik3c3 Zfyve16 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Jun Map3k1 Faf1 Arhgdib Map3k7 Pak1 Ripk2 Prkdc Parp1 Cflar Pak2 Lmnb1 Ptpn13 Lmnb2 Casp8 Rb1 Casp7 Casp3 Casp6 Sptan1 Lmna Map2k4 Fas Fadd Faslg Daxx Dffa Dffb Mapk8 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Abcc1 Slco1b2 Abcb1a Abcg2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Agxt Pc Mpc1 Gpt Aars2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Rpia Tpi1l2 Rpe G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Prkca Erbb4 Erbb3 Psen1 Nrg2 Adam17 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Ace Ren Agt FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Slc22a6 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Ugt2b1 Ugt1a2 Pdia2 Sdf2l1 Slc22a8 Hyou1 Alox12 Pdia6 Prxl2b Pdia4 Cyp2u1 Cyp2c11 Dnajb11 Alox5 Lta4h Ugt1a9 Alox15 Erp29 Cyp4f18 Cyp4f17 Ugt1a1 Ptgds Hspa5 Cyp2j4 Cyp2b2 Ugt2b7 Cyp4f4 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Slc22a6 Slc1a1 Ca1 Slc3a1 Slc38a4 Slc3a2 Slc7a6 Slc7a7 Slc7a5 Slc7a8 Slc7a9 Slc6a20a Slc4a4 Slc9a1 Aqp1 Slc22a2 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Elk1 Mapk3 Jun Fos Map2k1 Ptpn6 Epo Grb2 Plcg1 Epor Stat5a Raf1 Sos1 Hras Jak2 Mapk8 Shc1 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Cyp2d4 Oprm1 Ugt2b7 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Aldob Prps1 Rpia Pgm1 Gpi G6pd Pfkl Tkt Fbp1 Rpe Pgls HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Gad1 Aldh6a1 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd Aldh2 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Chrm3 Abcc8 Cacna2d2 Adcy10 Vamp2 Rab3a Rapgef4 Gnaq Glp1r Gnb1 Camkk1 Itpr3 Plcb1 Cacna1a Prkca Slc2a2 Cacnb1 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Gnb1 Ppp1ca Htr6 Creb1 Gngt1 Prkacb METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Grin1 Cyp3a9 Cyp2d4 Oprm1 Grin2a Cyp2b2 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Ahcy Cbs Mettl6 Mat2a Scly Cth Slc39a8 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Gnb1 Adcy2 Ptgdr Gngt1 Prkacb DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gpi Gbe1 Gys1 Ganab Pgm2 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Rock1 Gnb1 Lpar4 Itpr1 Plcb1 Srf Akt1 Adcy1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Ntpcr Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Pex13 Abcd1 Crot Acsl1 Pex11g Slc25a20 Abcd2 Cpt2 Pex14 Crat CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Hsd17b1 Ugt2b34l1 Cyp19a1 Akr1d1 Cyp17a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Ass1 Gad1 Abat Asl Adsl Nars1 Aspa Ddo Asns Dars1 Cad Asrgl1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Rela Map2k1 Itpr1 Prkcb Plcb1 Mapk1 Raf1 Prkca Mapk3 Hras Nfkbia Nfkb1 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Cyp2e1 Acss1 Aldh2 Ddc Acss2 Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct Aldh1b1 Cat GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Gh1 Mapk3 Irs1 Map2k1 Ptpn6 Ghr Grb2 Plcg1 Mapk1 Stat5a Stat5b Raf1 Ins2 Rps6ka1 Prkca Slc2a4 Hras Jak2 Shc1 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Agxt Pc Mpc1 Gpt Aars2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Ugp2 Ugdh Galk1 Pgm1 Uxs1 Gale Gck Galt PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Pik3cg Pik3r6 Plcb1 Vav1 Plcg1 Prkca Akt1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Npr1 Clock Nmnat1 Nampt Ppargc1a Rora Sirt1 Nqo1 Nmnat2 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Gnb1 Ppp1ca Htr7 Creb1 Gngt1 Prkacb PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Slc22a6 Ugt2b1 Ptgs1 Ptgs2 Ugt1a2 Pdia2 Sdf2l1 Slc22a8 Hyou1 Pdia6 Pdia4 Dnajb11 Cyp2c11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Ugt2b7 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Gpi Eno1 Pgam2 Aldoart2 Pkm Galm Pfkp Tpi1l2 Slc2a1 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d4 Cyp1a2 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Prkar1b Prkar2a Prkar2b Atp1b4 Uqcr11 Mcu Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Prkacb Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Slc9a1 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Cyp1a2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Fmo3 Chrna4 Ugt1a9 Cyp2a3 Ugt1a5 Chrnb2 Cyp2b2 Chrna3 Aox1 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Tmlhe Setd7 Bbox1 Aldh9a1 Shmt1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Txn1 Pde10a Adsl Rac1 Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Abcc4 Atad1 Atic Abcc5 Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Aox1 Hprt1 Prps1l1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Ak2 Nme2 Nme1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Txn1 Pde10a Adsl Rac1 Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Abcc4 Atad1 Atic Abcc5 Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Aox1 Hprt1 Prps1l1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Gclc Got1 Cth Gclm Mpst Ctns Cdo1 Cars1 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Elk1 Mapk3 Jun Map3k1 Fos Map2k1 Grb2 Raf1 Hras Map2k4 Stat6 Egfr Rasa1 Csnk2a1 Jak1 Egf Prkcb Stat3 Plcg1 Stat2 Srf Stat1 Prkca Sos1 Mapk8 Shc1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Gmppa Pmm1 Mpi Sord Uxs1 Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cbs Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Alpl Aox1 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Ugp2 Ugdh Pgm1 Uxs1 Gale Galk2 Galt EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Ace Ren Agt PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Ces1d Tymp Tyms Cda Slc28a1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Enpp1 Acp1 Tyr ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Ugt2b35 Atp1a2 Ugt2b1 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Ugt1a2 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Dnajb11 Ugt1a9 Erp29 Atp1b1 Cacnb1 Grin2a Atp1b3 Ugt1a1 Kcnd2 Atp1b2 Hspa5 Scn1b Chrnb2 Ugt2b7 Pomc MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Hsd17b10 Acat1 Hadh Echs1 Acadl Acss3 Acads Acaa2 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Plpp1 Agpat1 Gnpat Cept1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Sult1a1 Sult2b1 Chst11 Suox Bpnt1 Papss2 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Ace Ren Agt CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Cyp2d4 Cyp2c11 Ugt1a9 Ptgs1 Ptgs2 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Ak2 Nme2 Nme1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Slc5a1 Atp1a2 Atp1a1 Slc2a2 Atp1b1 Atp1a4 Atp1a3 Gck Atp1b3 Fxyd2 Atp1b2 Treh PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Maob Maoa Slc6a4 Cyp3a9 Cyp2d4 Aox1 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Gpt2 Slc25a22 Gpt Slc38a4 Slc1a4 Slc2a2 Slc2a4 Glud1 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Cmpk1 Tyms Rrm2b Slc28a3 Rrm2 Slc29a1 Ctps1 Slc28a1 Dck Nme1 Dctd WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Aldob Sdhd Sdhc Sdhb Pklr Sdha Cs Mdh1 Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Slc2a2 Idh1 Idh3a Dlst Pdhb Pgk1 Idh3b Aco2 Aco1 Dlat Dld Rpia Gpi G6pd Pfkl Taldo1 Slc1a5 Tkt Hk2 Slc16a1 Eno1 Pgam2 Gls2 Pkm Glud1 Pgls ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Tktl2 Pdha2 Slc16a4 Slc1a2 Sdhb Sdha Cs Mdh1 Dhtkd1 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Aldoart2 Idh3a Pdhb Pgk1 Idh3b Aco2 Aco1 Dlat Dld Rpia Gpi G6pd Taldo1 Hk2 Eno1 Gls2 Pkm Glud1 Pfkp HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Sc5d Msmo1 Hsd17b7 Cyp51 Nsdhl Dhcr24 Dhcr7 Lbr Ebp ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Jak1 Stat3 Mapk1 Mtor IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway Bche Ces2h Ces1d Oprm1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Plcb4 Ptpmt1 Ipmk Impa1 Cct3 Isyna1 Synj1 Vac14 Bpnt2 Becn1 Pik3c3 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Bcl2l1 Elk1 Cycs Mapk3 Rac1 Vav3 Rala Casp9 Pld1 Rhoa Chuk Ralgds Smad3 Map2k1 Smad4 Apaf1 Foxo4 Raf1 Hras Ralbp1 Akt1 Bad PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Gnaq Gnb1 Cyp21a1 Cyp11a1 Cyp11b2 Agtr1a SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Ddc Th ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Abcb1a Abcg2 Egfr NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Gclc Got1 Cth Gclm Mpst Ctns Cdo1 Cars1 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Rock1 Gnb1 Itpr1 Plcb1 Srf Lpar5 Akt1 Adcy1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Aldh1a1 Cyp3a73 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Glp1r Slc10a2 Gpbar1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Pik3cg Pik3r6 Irs1 Insr Map2k1 Grb2 Mapk1 Raf1 Ins2 Slc2a4 Sos1 Hras Irs2 Map2k2 Pdpk1 Foxo1 Mapk8 Akt1 Shc1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Lars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Ip6k1 Ipmk Impa1 Isyna1 Synj1 Bpnt2 Ppip5k1 Nudt3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Pex13 Abcd1 Crot Acsl1 Pex11g Slc25a20 Abcd2 Cpt2 Pex14 Crat ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Plcd4 Pik3r4 Impa1 Synj1 Vac14 Becn1 Pik3c3 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Drd1 Adcy2 Prkacb LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Cyp3a9 Cyp3a73 Ephx1 Cyp2b2 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Ccnb1 Pcna Ccne1 Ccnd1 Gadd45b Cdk4 Cdk2 Bcl2 Cdk1 E2f1 Bax Apaf1 Cdkn1a Rb1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C3 Cfd C5 C1qb C6 C1qa C7 Serping1 C9 C1s C1r C8a Masp2 Cfb C2 C4a C1qc Mbl2 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psma2 Psmc3 Psma1 Ubd Psmd13 Psmb5 Psmb4 Psmb7 Ubc Psmb6 Psmb1 Psmb3 Psmd4 Psmb2 Uba1 Psma7 Psma4 Psmc6 Psmc5 Psma3 Psma6 Psma5 Psmc2 Psmc1 Psmc4 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Elk1 Map2k7 Calm2 Jun Map3k1 Gna11 Pld1 Src Fshb Lhb Map2k1 Gnrh1 Gnrhr Grb2 Mapk1 Hbegf Camk2a Raf1 Adcy5 Cdc42 Egr1 Hras Mmp14 Lrrc7 Mmp2 Actn4 Atf4 Erbb4 Cga Itpr1 Plcb1 Prkcb Prkca Mapk8 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Xdh Cyp2e1 Cyp2c11 Cyp1a2 Cyp2a3 Nat1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Ugt2b7 Pomc HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Gmppb Aldob Pmm1 Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Gpi Eno1 Aldoart2 Pkm Hk2 Pfkp BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Elk1 Vav1 Mapk3 Rac1 Ppp3ca Jun Map3k1 Ppp3cb Syk Fos Map2k1 Grb2 Cd79b Raf1 Lyn Orai1 Blnk Hras Nfatc4 Nfatc3 Nfatc2 Ppp3cc Btk Prkcb Plcg1 Prkca Sos1 Mapk8 Shc1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Rock1 Gnb1 Itpr1 Plcb1 Srf Lpar1 Akt1 Adcy1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Hmgcl Oxct1 Acat1 Bdh1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Ass1 Gad1 Abat Asl Adsl Nars1 Aspa Ddo Asns Dars1 Cad Asrgl1 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Cyp3a73 Top2a PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pisd Pcyt1a Chka Cept1 Pcyt2 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Pik3r4 Cct3 Itpk1 Plcd1 Itpka Ambra1 Miox Ptpmt1 Impa1 Isyna1 Vac14 Becn1 Sacm1l Inpp1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Endog Dffa Top2a Casp7 Casp3 Cad Hmgb2 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Gnb1 Prkar1b Prkar2a Prkar2b Gngt1 Adcy10 Prkacb Prkaca GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Kars1 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Prps1 Rpia Pgm1 Gpi Tktl2 G6pd Taldo1 Aldoart2 Fbp1 Rbks Pfkp Rpe TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Gusb Ugt8 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C3 C5 C1qb C6 C1qa C7 C9 C1s C1r C8a C2 C4a C1qc GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Aldob Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Pkm Galm Tpi1l2 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Pfkfb2 Sord Fbp1 Aldoa CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Gusb Ugt8 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Bst1 Nudt12 Nnmt Nnt Nampt Nmrk1 Qprt Enpp1 Nadsyn1 Nmnat2 Pnp Aox1 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Pfkfb2 Gpi Sord ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Ptgs1 Ptgs2 Top2a Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Abcc3 Erp29 Ugt1a1 Abcb1a Hspa5 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Abcb1a Slc22a1 Bad SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Wars1 Tdo2 Kynu Cyp1a1 Acmsd Ido1 Aldh2 Ddc Haao Aadat Aanat Tph1 Asmt Kmo Inmt Wars2 Cat LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Ikbkb Slc25a1 Myd88 Traf6 Cd14 Tirap Sdhd Ikbkg Tlr4 Sdhc Nfkbia Acly Sdhb Sdha Mdh1 Cs Nfkb1 Rela Chuk Acaca Me1 Pfkp HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Gng12 Gnb1 Adcy2 Avpr2 Gngt1 Fshr Prkacb COAGULATION%SMPDB%SMP0000586 Coagulation Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Acss2 Cyp2e1 Acss1 Aldh1b1 Aldh2 Cat MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Gars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Ugp2 G6pc1 B4galt1 Pgm1 Gale Glb1 Lct Gla Galt Gaa Akr1b1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Sc5d Msmo1 Hsd17b7 Cyp51 Nsdhl Dhcr24 Dhcr7 Lbr Ebp TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Abcc1 Slco1b2 Abcb1a Abcg2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Nmnat1 Nampt Tp53 Sirt1 Nqo1 Nmnat2 Aifm2 Cd38 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Sdhd Slc7a7 Sdhc Sdhb Sdha Cs Slc38a5 Dhtkd1 Idh3g Pc Suclg1 Me1 Mpc1 Suclg2 Fh Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Got2 Slc1a5 Slc1a4 Acly Slc16a1 Gls2 Glud1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Rpia Tpi1l2 Rpe KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Ren Clcnkb Atp1a2 Slc12a6 Atp1a1 Atp1b1 Atp1a4 Atp1a3 Slc12a1 Atp1b3 Fxyd2 Atp1b2 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Eprs1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Ddc Th SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Mapk3 Crk Nfkbia Gngt1 Cxcl12 Nfkb1 Pxn Gnaq Pik3c2g Gnb1 Ptk2 Map2k1 Bcar1 Cxcr4 Plcg1 Mapk1 Gnai1 Ptk2b Raf1 Hras ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Ace Ren Agt Agtr1a DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Drd1 Grin1 Maob Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Cyp3a9 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Aox1 Maoa Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Aldob Pfkm Fbp2 Aldoc Tpi1l2 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Cyp1a2 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Agxt Pc Mpc1 Gpt Aars2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Traf2 Map2k4 Ikbkb Map2k7 Mapk14 Ikbkg Nfkbia Jun Map3k1 Nfkb1 Chuk Atf1 Casp2 Ripk1 Tank Tnf Map2k6 Map4k2 Map2k3 Mapk8 Tradd Cradd TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Abcd1 Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Pik3r6 Plcb1 Plcg1 Prkca Akt1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Cpt1a Acsl1 Hadh Slc25a20 Hadha Hadhb Echs1 Acadl Cpt2 Acaa2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Nudt4 Itpka Ip6k2 Inpp4a Ipmk Impa1 Isyna1 Inpp1 Ppip5k1 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Aldob G6pc1 Bpgm Gpi Pank3 Fbp1 Pgm1 Pc Mpc1 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Fmo3 Chrna3 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Aox1 Ugt1a9 Cyp2a3 Atp1b1 Ugt1a5 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Cyp2b2 Pomc HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Uroc1 Hdc Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Ftcd Hal Cndp1 Aldh2 Maoa Aoc1 Aldh3a1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Iars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Got2 Mdh2 Slc25a11 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Bhmt Mat2a Aldh7a1 Shmt1 Chdh Gnmt Slc44a1 Dmgdh Mtr Shmt2 Sardh PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C8a Masp2 C2 C4a Mbl2 C3 C5 C6 C7 C9 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Ces1d Tymp Tyms Cda Slc28a1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Gad1 Aldh6a1 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd Aldh2 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Cyp3a73 Top2a TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Pc Me1 Mpc1 Slc25a11 Acly Pdhb Mdh1 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway P2ry12 Cyp3a73 Cyp2c11 Cyp1a2 Abcb1a Cyp2b2 Pon1 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Adra1a Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Hsd17b10 Mecr Ppt1 Hadha Hadhb Echs1 Acaa2 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Gab2 Map2k7 Mapk14 Fyn Rac1 Vav3 Syk Map2k1 Grb2 Mapk1 Raf1 Lyn Pik3r1 Lat Hras Tnf Map2k6 Map2k2 Map2k3 Akt1 Map2k4 Inpp5d Btk Il13 Pla2g4a Fcer1a Il4 Plcg1 Il5 Kras Prkca Pdk1 Ms4a2 Sos1 Nras Csf2 Lcp2 Mapk8 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 L2hgdh PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Rpia Gpi G6pd Tktl2 Taldo1 Fbp1 Rbks Pgm1 Aldoart2 Pfkp Rpe Prps2 Pgls SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Plcb1 Ikbkb Mapk1 Prkca Mapk3 Ikbkg Creb1 Nos3 Nfkb1 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Btd Hlcs Acacb LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Ass1 Gad1 Abat Asl Adsl Nars1 Aspa Ddo Asns Dars1 Cad Asrgl1 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Gad1 Ggt6 Cdo1 Csad Ado SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Txn1 Pde10a Adsl Rac1 Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Abcc4 Atad1 Atic Abcc5 Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Aox1 Hprt1 Prps1l1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Chaf1a Btg2 Hoxb9 Btg1 Prmt1 Ccnd1 Ngf Fgf1 Tp53 Rb1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Gucy1a2 Trpv4 Prkg2 Gucy1a1 Trpc7 Trpc4 Adcy10 Kcnq4 Trpc3 Gucy1b1 Kcnq3 Kcnq2 Nos3 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp2d4 Cyp2c11 Cyp1a2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Abcc1 Cmpk1 Pcyt1a Dck Pcyt2 Nme1 Slc22a3 Chpt1 Sult1a1 Abcc3 Abcb1a Slc22a1 Abcg2 Pgk1 Slc22a2 Abcc4 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d4 Abcb1a GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Ugp2 Ugdh Galk1 Pgm1 Uxs1 Gale Gck Galt ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c11 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Ptgs1 Ptgs2 Top2a Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Abcc3 Erp29 Ugt1a1 Abcb1a Hspa5 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Gusb Ugt8 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification As3mt Gsto1 Aqp9 Aqp7 Slc2a4 Slc2a1 Pnp TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Ip6k1 Itpka Impa1 Isyna1 Inpp4b Itpk1 Inpp1 Ppip5k1 Nudt3 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Sars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Rock1 Gnb1 Itpr1 Plcb1 Srf Lpar2 Akt1 Adcy1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway Nr1h4 Slc10a2 Fgf19 Fgfr3 Fgfr4 Fgfr1 Fgfr2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Aldob Gapdhs Bpgm Gpi G6pc3 Eno1 Pkm Galm Pfkp Tpi1l2 Pgk2 Slc2a13 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Snta1 Sntb1 Abcc8 Cacna1a Slc2a2 Cacna2d2 Cacnb1 Gcg Scn5a FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Gmppb Aldob Pmm1 Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Pex13 Abcd1 Crot Acsl1 Pex11g Slc25a20 Abcd2 Cpt2 Pex14 Crat INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Mylk Gnb1 Adcy2 Gngt1 Ptgir Prkacb Myl3 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Ikbkb Mapk14 Myd88 Traf6 Cd14 Tirap Ikbkg Tlr4 Nfkbia Map3k1 Nfkb1 Rela Chuk Map3k7 Ecsit Tollip Map2k4 Irak1 Tlr7 Tab2 Tlr6 Tlr5 Tlr3 Tlr2 Mapk8 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Abcc1 Bche Ces2h Ces1d Top1 Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Abcb1a Hspa5 Abcg2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Pank1 Enpp1 Vnn1 Ppcdc Coasy METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Ace Ren Agt 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Elk1 Ikbkb Map2k7 Nfkbia Jun Map3k1 Nfkb1 Chuk Pak1 Mapk1 Hras Map2k6 Map2k2 Pdpk1 Akt1 Creb1 Gngt1 Atf2 Arhgef7 Prkacb Adora2a Braf Map3k4 Gnb1 Nfkb2 Prkcz Rap1a Pard6a Rapgef3 Rapgef2 Rps6ka1 Mapk11 Mapk8 Bad ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Gnaq Itpr1 Plcb1 Prkca HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Hsd17b10 Mecr Ppt1 Hadha Hadhb Echs1 Acaa2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Tars1 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Sdhd Sdhc Sdhb Pklr Sdha Cs Mdh1 Dhtkd1 Suclg1 Mpc1 Fh Idh1 Idh3a Dlst Pdhb Pgk1 Idh3b Aco2 Aco1 Dlat Dld Rpia Gpi G6pd Pfkl Taldo1 Tkt Hk2 Gls Slc16a1 Eno1 Pgam2 Pkm Glud1 Slc1a3 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Ugp2 Ugdh Galk1 Pgm1 Uxs1 Gale Gck Galt PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rps24 Rpl14 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Aars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rpl7 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rps6 Rplp2 Rpl24 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rps15 Rpl23 Rpl8 Rpl13a Rpl9 Rpl18a Rpl38l1 Rps18l1 Rps20 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Adra1a Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Ace Ren Agt BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Ipmk Prex1 Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Uroc1 Hdc Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Ftcd Hal Cndp1 Aldh2 Maoa Aoc1 Aldh3a1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Pde4d Cyp3a73 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Hadh Slc25a20 Acadm Hadha Hadhb Echs1 Acaa2 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Sult1a1 Sult2b1 Chst11 Suox Bpnt1 Papss2 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Cyp11b3 Hsd11b1 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Dnajb11 Srd5a1 Hsd17b3 Erp29 Cyp19a1 Akr1c1 Ugt1a1 Akr1d1 Hspa5 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Egln3 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Flt1 Vegfa NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Ugt2b35 Ugt2b1 Oprm1 Ugt1a2 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Ugt2b7 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Cyp1a2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pisd Chka Cept1 Pcyt2 Ptdss1 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Yars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Aldob Gapdhs Bpgm Gpi G6pc3 Eno1 Pkm Galm Pfkp Tpi1l2 Pgk2 Slc2a13 LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Pik3r4 Plcd3 Itpk1 Ippk Pik3c3 Fig4 Itpka Ambra1 Miox Ptpmt1 Inpp4a Pikfyve Ipmk Impa1 Isyna1 Vac14 Becn1 Inpp1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2u1 Cyp2d5 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Hsd17b10 Ugt1a2 Acadsb Ivd Cyp2c11 Hadha Cyp2a3 Hadhb Ehhadh Cyp2b2 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Dars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Slc5a1 Atp1a2 Atp1a1 Slc2a2 Atp1b1 Atp1a4 Atp1a3 Lct Atp1b3 Fxyd2 Atp1b2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Ace Ren Agt METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Snta1 Sntb1 Scn5a LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Aldh1a1 Cyp2d4 Cyp3a73 Cyp2c11 Ugt1a9 Abcc10 Cyp2b2 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Prkca Erbb4 Erbb3 Psen1 Nrg2 Adam17 Egfr RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Mylk Pcna Rps6kb1 Ccnd1 Rac1 Cap1 Vav3 Ccnd3 Map3k1 Wasf1 Cfl1 Pld1 Ppp1r12b Actb Cdk5 Pak1 Myl2 Limk1 Arfip2 Pdgfra Cdkn1a Ralbp1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cbs Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Aldoa Hk2 Galm Pklr Pgk1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Gusb Ugt8 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Irak1 Ikbkb Fadd Myd88 Traf6 Ubc Ikbkg Tlr4 Nfkbia Map3k1 Nfkb1 Rela Chuk Map3k7 Camkk1 Tnfrsf1b Il1a Ripk1 Tnfrsf1a Il1r1 Tnf Map3k14 Tradd METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Cyp3a9 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Cyp2b2 Pomc BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect Aldob Sdhc Sdhb Cs Mdh1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Slc2a2 Idh1 Idh3a Dlst Pdhb Pgk1 Idh3b Aco2 Aco1 Dld Rpia Gpi G6pd Pfkl Slc1a5 Tkt Pdhx Ogdh Slc16a1 Eno1 Pgam2 Pkm Glud1 Pgls CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Hsd17b1 Ugt2b34l1 Cyp19a1 Akr1d1 Cyp17a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Bhmt Ahcy Mat2a Aldh7a1 Chdh Mtr BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Btd Hlcs Acacb FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Ace Ren Agt ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Cars1 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Agxt Pc Mpc1 Gpt Aars2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Ces2h Cyp3a73 Ces1d Ugt1a9 Slco1b2 Impdh1 Abcb1a Abcg2 Impdh2 Ugt2b7 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Cyp3a73 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Rdh16 Dhrs9 Bco1 Cyp3a9 Rpe65 Cyp3a18 Cyp26a1 Dgat1 Retsat Lrat Pdia2 Sdf2l1 Hyou1 Aldh1a1 Pdia6 Pdia4 Dnajb11 Cyp2a3 Erp29 Ugt1a1 Hspa5 Cyp2b2 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway P2ry12 Cyp3a73 Cyp2c11 Cyp1a2 Abcb1a Cyp2b2 Pon1 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Tpo Tg Cyba Cybb Nox4 Nox3 Duox2 Slc5a5 Duox1 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Aldob Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Pmm2 Fbp1 Tgds Amigo3 Tpi1l2 Akr1b1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Elk1 Ikbkb Map2k7 Nfkbia Jun Map3k1 Nfkb1 Chuk Pak1 Mapk1 Adcy2 Hras Map2k6 Map2k2 Pdpk1 Akt1 Adora2b Creb1 Gngt1 Atf2 Arhgef7 Prkacb Braf Map3k4 Gnb1 Nfkb2 Prkcz Rap1a Pard6a Rapgef3 Rapgef2 Rps6ka1 Mapk11 Mapk8 Bad FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Aldoa Hk2 Galm Pklr Pgk1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Sst Abcc8 Cacna1a Slc2a2 Cacna2d2 Cacnb1 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Pik3cg Pik3r6 Rps6kb1 Slc7a5 Tsc2 Eif4ebp1 Tsc1 Eif4e Irs1 Insr Ins2 Mtor Irs2 Akt1 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Hmgcl Oxct1 Acat1 Bdh1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling Hif1a Il1b Sirt3 Nlrp3 P4ha3 Tlr4 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Cyp3a73 Ugt1a9 Ugt2b7 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Oprk1 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Gnb1 Ppp1ca Htr4 Creb1 Gngt1 Prkacb ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Cyp1a1 Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Erp29 Hsd17b1 Ugt1a1 Comt Hspa5 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Elk1 Map2k7 Mapk14 Cacna2d2 Jun Map3k1 Gna11 Pld1 Src Fshb Lhb Map2k1 Cacna1f Gnrh1 Cacna1d Gnrhr Grb2 Mapk1 Hbegf Camk2a Raf1 Egr1 Hras Mmp14 Mmp2 Map2k3 Actn4 Atf4 Adcy1 Cacna1c Cga Egfr Itpr1 Plcb1 Prkcb Map3k2 Prkca Sos1 Cacnb1 Mapk8 Prkaca TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Pik3r4 Cct3 Itpk1 Ippk Bpnt1 Pik3c3 Plcd1 Inpp5j Itpka Ambra1 Miox Ptpmt1 Inpp4a Ipmk Impa1 Isyna1 Vac14 Becn1 Sacm1l VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Elk1 Ikbkb Mapk14 Myd88 Traf6 Cd14 Tirap Ikbkg Tlr4 Nfkbia Jun Map3k1 Nfkb1 Fos Rela Chuk Map3k7 Map2k6 Map2k3 Ecsit Tollip Map2k4 Irak1 Tlr7 Tab2 Tlr3 Tlr2 Eif2ak2 Ppara Mapk8 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Ptpmt1 Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Ptpn7 Cd3g Cd247 Pik3cg Elk1 Vav1 Cd3d Mapk3 Ubc Fyn Rac1 Ppp3ca Nfkbia Jun Map3k1 Ppp3cb Nfkb1 Fos Rela Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Map2k4 Nfatc4 Nfatc3 Nfatc2 Ppp3cc Prkcb Plcg1 Prkca Zap70 Sos1 Cd3e Mapk8 Shc1 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Abcc5 Ppat Xdh Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Rac1 Impdh1 Aox1 Hprt1 Gmps Abcc4 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacna2d2 Cacnb1 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Grin1 Itpr1 Xdh Nos1 Prkca Grin2a Ppp3ca Dlg4 Prkacb Aldh2 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Tktl2 Slc16a4 Sdhd Sdhc Sdhb Sdha Cs Mdh1 Dhtkd1 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Aldoart2 Idh3a Dlst Pdhb Pgk1 Aco1 Dlat Dld Rpia Gpi G6pd Taldo1 Gls Eno1 Pgam2 Pkm Glud1 Pfkp Slc2a1 Pgls TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Alpl Aox1 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Pik3r4 Inpp5d Erbb2 Synj1 Inpp4b Pik3c2a Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 Plcb1 Pik3cd Pip4k2a Pikfyve Pik3r1 Vac14 Becn1 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cyp3a73 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Cyp2c11 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Gclc Got1 Cth Gclm Mpst Ctns Cdo1 Cars1 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Nr1h4 Slc10a2 Gpbar1 Slco1a4 Abcc4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Pex13 Abcd1 Acsl1 Slc25a20 Phyh Abcd2 Cpt2 Pex14 Crat Aldh2 Hacl1 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc2a1 Nme2 Lalba ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Cyp2c11 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Cyp2b2 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Pfkm G6pc1 Gpi Eno1 Pgam2 Aldoa Hk2 Galm Tpi1l2 Pklr CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Gnb1 Gngt1 Mc2r Prkacb Pomc GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Gusb Ugt8 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Aldh1a1 Cyp3a73 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin1 Calm2 Nos1 Prkca Grin2a Ppp3ca Dlg4 Prkacb AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Hsp90aa1 Arnt Ahr EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Elk1 Map2k7 Mapk3 Erbb4 Jun Map3k1 Fos Rasa1 Csnk2a1 Map2k1 Egf Prkcb Stat3 Grb2 Plcg1 Stat5a Srf Raf1 Prkca Hras Jak2 Mapk8 Shc1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Lpar6 Rock1 Gnb1 Srf Akt1 Adcy1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Gmppb Aldob Pmm1 Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Gusb Ugt8 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Pfkm G6pc1 Gpi Eno1 Pgam2 Aldoa Hk2 Galm Tpi1l2 Pklr PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp2d4 Cyp1a2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a9 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Aldob Pfkm Fbp2 Aldoc Tpi1l2 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Hars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Gnb1 Lhcgr Ppp1ca Lhb Adcy2 Creb1 Gngt1 Prkacb Cga LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Slc5a1 Atp1a2 Atp1a1 Slc2a2 Atp1b1 Atp1a4 Atp1a3 Lct Atp1b3 Fxyd2 Atp1b2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Gpi Pkm Pfkp Tpi1l2 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Lpin1 Dgat1 Gpam Agpat1 Gpd1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cbs Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Gad1 Aldh6a1 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd Aldh2 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Dld Aldh8a1 Acmsd Dlst Dhtkd1 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Wars1 Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Ip6k1 Itpka Inpp4a Ipmk Impa1 Isyna1 Inpp4b Itpk1 Ippk Inpp1 Ppip5k1 Nudt3 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Hsd17b1 Ugt2b34l1 Cyp19a1 Akr1d1 Cyp17a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Atp4a Ren Atp4b Trpv5 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc12a3 Clcnkb Slc8a1 Atp1b1 Atp1b3 Aqp3 Atp1b2 Aqp2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Gab2 Map2k7 Fyn Rac1 Syk Map2k1 Lck Grb2 Mapk1 Raf1 Lyn Pik3r1 Lat Blnk Hras Tnf Map2k2 Akt1 Inpp5d Il13 Fcer1a Il4 Plcg1 Kras Prkca Ms4a2 Nras Csf2 Mapk8 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Ikbkb Sucnr1 Mapk3 Ptgs1 Ikbkg Creb1 Nfkb1 Chuk Plcb1 Mapk1 Prkca Mapk11 Nos3 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Sult1a1 Fmo1 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 Cyp2b2 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Arhgdib Apaf1 Cycs Parp1 Arhgap5 Casp1 Prf1 Arhgap32 Casp8 Jun Casp9 Casp3 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Aldob Pfkm Fbp2 Aldoc Tpi1l2 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Nars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Aldob Gapdhs Bpgm Gpi G6pc3 Eno1 Pkm Galm Pfkp Tpi1l2 Pgk2 Slc2a13 INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Gnb1 Ppp1ca Adcy2 Hrh2 Creb1 Gngt1 Prkacb DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Gnb1 Itpr1 Plcb1 Lpar3 Akt1 Adcy1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Dlat Dld Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Gls2 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 96%10225211 Pre-NOTCH Transcription and Translation Prkci Elf3 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-RNO-453276.1 Regulation of mitotic cell cycle Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Aurka Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Cdc14a Psmd7 Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 OPIOID SIGNALLING%REACTOME%R-RNO-111885.1 Opioid Signalling Ppp1ca Adcy5 Adcy6 Ppp2cb Ppp2ca Adcy9 Pde4a Pde4b Prkaca Prkacb Prkcg Prkcd Oprm1 Gnai2 Gnai1 Prkca Gnai3 Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Ppp2r5d Gng3 Grk2 Gnal Pomc Gng5 Gng4 Pde4c Gnaq Gng7 Pde4d Gng8 Gngt1 Gnat3 Prkar2a Prkar2b Ppp2r1b Ppp2r1a Cdk5 Pde1b Pde1c Gnb2 Gnb1 Pde1a Gnb4 Gnb3 Gnb5 Gng11 Plcb4 Plcb3 Mapk1 Pla2g4a Pdyn Plcb2 Plcb1 Ppp1r1b Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME DATABASE ID RELEASE 96%10223491 SLC-mediated transport of neurotransmitters Slc25a22 Slc6a2 Slc17a7 Slc6a1 Slc17a8 Slc6a4 Slc6a3 Slc17a6 Slc22a2 Slc6a19 Slc6a5 Slc22a1 Slc32a1 Slc6a7 Slc6a15 Slc6a9 Slc6a14 Slc6a11 Slc6a13 Slc6a20 Slc25a18 SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 96%10223741 Surfactant metabolism Slc34a1 Adra2a Adora2b Adgrf5 Adora2a Adra2c Ctsh Slc34a2 Dmbt1 Sftpa1 Ttf1 Lmcd1 Sftpb Napsa Sftpd Sftpc Ccdc59 Abca3 P2ry2 Gata6 Zdhhc2 Ckap4 REGULATION OF TP53 EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224927 Regulation of TP53 Expression Tp53 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-RNO-110362.1 POLB-Dependent Long Patch Base Excision Repair Parg Polb Fen1 Parp2 Parp1 Apex1 Adprs Lig1 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-RNO-8878171.1 Transcriptional regulation by RUNX1 H2ab2 Arid1a Arid1b Lmo2 Lmo3 Ccnh H2ac4 Serpinb13 Zfpm1 Actl6a Actl6b Smarce1 Gata3 Gata1 Gata2 Setd1b Setd1a Ring1 Abl1 ENSRNOG00000066901 Tp73 Ccnd2 Phc2 Cbx6 Ccnd3 Phc1 Cbx4 Cbfb Ccnd1 Cbx2 Esr1 Phc3 Kmt2d Crebbp Cdk7 Cdk6 Kmt2a Kmt2b Kmt2c H2ac18 Tcf3 Sin3a Sin3b Csnk2a2 Ctsk Ctsl Csnk2a1 Bmi1 Mnat1 Pbrm1 Prmt6 Hist1h2bq Prmt1 Smarcb1 Hdac1 Wdr5 Ash2l Yaf2 Csnk2b Pax5 H2aj Elf1 Elf2 Tal1 Smarca2 Psma4 Smarca4 Foxp3 Psma3 H3-3b Yap1 Hist3h2ba Psma6 Ep300 Psma5 Rnf2 Psma2 ENSRNOG00000068602 Psma1 Itch Rps27a Smarcd1 Psmd12 Tcf12 Psmd11 Smarcd3 Pcgf5 Psmd14 Smarcd2 Psmd13 Ptpn11 H2bc18 Runx1 Kat2b H2az2 Rbbp5 H2bc4 Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Pml Psmb6 Smarcc1 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 CAM PATHWAY%REACTOME%R-RNO-111997.1 CaM pathway Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkar2a Prkar2b Pde1b Pde1c Pde1a Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 SIALIC ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%10223803 Sialic acid metabolism St8sia6 St8sia4 St8sia5 Npl Neu2 Neu3 Neu4 Neu1 Cmas St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 St3gal6 St6galnac2 St3gal4 St3gal5 St3gal2 St3gal3 Slc35a1 St3gal1 Nanp St6gal1 Glb1 St6gal2 Nans St8sia2 St8sia3 St8sia1 Ctsa Gne INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 96%10224003 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate Adhfe1 L2hgdh D2hgdh REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-RNO-9909648.1 Regulation of PD-L1(CD274) expression Ywhag Suz12 Ddost Eed Gsk3b Cd274 Os9 Pdcd1 Rnf5 Sel1l Magt1 Rbbp4 Rbbp7 Mib2 Pdcd1lg2 Prkab2 Prkab1 H2ab2 H2ac4 ENSRNOG00000066901 Ccnd1 Kmt2a Kmt2c H2ac18 Csnk2a2 Csnk2a1 Hist1h2bq Wdr5 Ash2l Csnk2b H2aj Psma4 Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 H2bc18 H2az2 Skp1 Rbbp5 H2bc4 Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Nek2l1 Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Prkaa1 Derl3 Psmd2 Prkaa2 Derl2 Psmd1 Stt3b Adrm1 Rbx1 Cul1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Tmem258b Tusc3 Cdk4 Cul3 Ezh2 Erlec1 B3gnt3 Dad1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-RNO-419408.1 Lysosphingolipid and LPA receptors Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%10222759 Mitochondrial transcription initiation Polrmt Tfb2m Tfam NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-RNO-375165.1 NCAM signaling for neurite out-growth Creb1 Spta1 St8sia4 Col4a1 Ptpra Col4a2 Ncam1 Sptb Sptbn1 Sptbn2 Ptk2 Mapk3 Sptan1 Sptbn5 Rps6ka5 Nras Sptbn4 Mapk1 Grb2 Fyn Kras Sos1 Hras St8sia2 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 96%10222839 Toll Like Receptor 5 (TLR5) Cascade Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 96%10224273 Elastic fibre formation Tgfb2 Tgfb3 Loxl2 Ltbp3 Ltbp2 Loxl1 Furin Ltbp4 Fbln2 Loxl4 Ltbp1 Loxl3 Fbln5 Efemp2 Mfap4 Mfap5 Mfap2 Itgb8 Itgb6 Bmp7 Gdf5 Bmp4 Itgb1 Bmp2 Lox Itgb3 Fbn1 Eln Itga8 Itgav Bmp10 Vtn Tgfb1 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-RNO-381070.1 IRE1alpha activates chaperones Ern1 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223831 Sodium-coupled sulphate, di- and tri-carboxylate transporters Slc13a4 Slc13a1 DEPURINATION%REACTOME DATABASE ID RELEASE 96%10222431 Depurination Acd Terf1 Hist1h2ai Mpg Ogg1 H2aj Terf2ip Mutyh Tinf2 H2ab2 Pot1 Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m Terf2 H2bc1 Neil3 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10225011 Rab regulation of trafficking Sytl1 Tbc1d25 Tbc1d24 Arf6 Map1lc3b Rab21 Chml Rab9a Rab9b Dennd2a Rab1A Dennd2c Ric1 Rab10 Rab13 Rab12 Rab14 Rab18 Rab8b Rab8a Rgp1 Ankrd27 Dennd3 Rab3il1 Madd Akt3 Akt2 Akt1 Sbf2 Sbf1 Optn Rab11b Rab11a Rab31 Rab35 Rab38 Tsc2 Tsc1 Rab3gap2 Rab3gap1 Dennd1a Rab1b Ulk1 Dennd1b Trappc2l Dennd1c Rin3 Gabarap Rin1 Rin2 Mon1b Dennd6a Mon1a Dennd6b Rab5a Rab4a Trappc10 Rabgap1 Rab33b Rab33a Tbc1d2 Hps1 Tbc1d7 Gabarapl2 Ccz1 Hps4 Trappc12 Trappc11 Trappc13 Rab3a Rinl Gapvd1 Als2cl Gdi1 Rabgef1 Gdi2 Chm Rab7a Rab7b Dennd4c Dennd4a Dennd4b Ywhae Rab27a Rab39a Tbc1d14 Rab27b Tbc1d13 Tbc1d16 Tbc1d15 Tbc1d17 Trappc6b Trappc6a Trappc9 Trappc8 Tbc1d10c Trappc5 Trappc4 Trappc3 Dennd5a Trappc2 Tbc1d10b Trappc1 Rab6b Tbc1d10a Rab6a Rab5c Rab5b Dennd5b Als2 Rab3ip CREATINE METABOLISM%REACTOME%R-RNO-71288.1 Creatine metabolism Gamt Ckmt1 Slc6a7 Ckmt2 Gatm Slc6a8 Ckm Slc6a11 Slc6a12 Ckb PURINE SALVAGE%REACTOME%R-RNO-74217.1 Purine salvage Gmpr2 Pnp Ampd3 Ampd2 Ampd1 Adk Gmpr Hprt1 Dck Aprt Ada Dguok EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-RNO-3928663.1 EPHA-mediated growth cone collapse Fyn Lyn Yes1 Src Rhoa Ngef UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223823 Unblocking of NMDA receptors, glutamate binding and activation Grin1 Grin2d Grin2c Grin2b Grin2a Lrrc7 Gria4 Gria3 Camk2g Camk2d Calm3 Gria2 Camk2b Dlg1 Dlg2 Gria1 Actn2 Dlg3 Dlg4 Camk2a Nefl TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME DATABASE ID RELEASE 96%10225435 TGFBR3 regulates TGF-beta signaling Tgfb2 Tgfbr3 Gipc1 Arrb2 Arrb1 Tgfbr1 Tgfbr2 Tgfb1 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223563 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Esr1 Atad2 Lhb Cga TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-RNO-202430.1 Translocation of ZAP-70 to Immunological synapse Zap70 RT1-Db2 Cd3g Cd247 RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck Ptpn22 RT1-Ba RT1-Bb ENSRNOG00000065955 Trbv16 RT1-Da IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-RNO-9732724.1 IFNG signaling activates MAPKs Ifngr2 Ifngr1 Mapk1 Raf1 Jak2 Mapk3 Ifng LEADING STRAND SYNTHESIS%REACTOME%R-RNO-69109.1 Leading Strand Synthesis Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME DATABASE ID RELEASE 96%10224365 Metabolism of Angiotensinogen to Angiotensins Cpb2 Cpa3 Atp6ap2 Ctsd Ace Mme Ctsg Gzmf Agt Ren1 Ace2 Enpep Ctsz Cma1 Ces1d Cpb1 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-RNO-77285.1 Beta oxidation of myristoyl-CoA to lauroyl-CoA Hadha Hadhb Acadl THE AIM2 INFLAMMASOME%REACTOME%R-RNO-844615.1 The AIM2 inflammasome Aim2 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-RNO-177128.1 Conjugation of salicylate with glycine Glyatl3 Acsm2 Acsm4 Acsm5 Glyat ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME DATABASE ID RELEASE 96%10225491 Antigen processing: Ub, ATP-independent proteasomal degradation Psmb6 Psmb6l1 Psmb1 Psmb3 Psmb2 Psma4 Psma3 Psme2 Psme1 Psma7 Psma6 Psmb9 Psma5 Psmb10 Psma2 Psmb8 Psma1 Psmb5 Psmb4 Psmb7 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223625 Orexin and neuropeptides FF and QRFP bind to their respective receptors Npffr1 Npffr2 Npff Hcrtr2 Hcrtr1 Qrfprl Qrfpr Qrfp Hcrt BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-RNO-9026762.1 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Gstm4 Ltc4s NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 96%10224573 Negative regulation of TCF-dependent signaling by WNT ligand antagonists Dkk1 Dkk2 Dkk4 Kremen2 Kremen1 Lrp6 Sost INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME%R-RNO-912526.1 Interleukin receptor SHC signaling Inpp5d Pik3ca Jak2 Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Grb2 Pik3r2 Pik3r3 Inppl1 Sos1 Pik3cd RECYCLING OF EIF2:GDP%REACTOME%R-RNO-72731.1 Recycling of eIF2:GDP Eif2b3 Eif2b2 Eif2s3 Eif2b5 Eif2b4 Eif2s2 Eif2b1 Eif2s1 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%10225287 tRNA modification in the mitochondrion Yrdc ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME DATABASE ID RELEASE 96%10225157 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Pik3r5 Pik3cg Irs2 Pik3ca Jak2 Epor Pik3cd Lyn Pik3r1 Epo Pik3cb Gab1 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME DATABASE ID RELEASE 96%10224401 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Alox12 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME DATABASE ID RELEASE 96%10223473 Biosynthesis of specialized proresolving mediators (SPMs) Alox12 Cyp3a9 Alox5ap Gpx4 Hpgd Alox5 Lta4h Alox15 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Ephx2 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a62 Cyp3a2 Ptgs2 Gstm4 Ltc4s NON-CODING RNA METABOLISM%REACTOME%R-RNO-194441.1 Non-coding RNA Metabolism Nup133 Nup210 Nup155 Nup153 Ddx20 Snrpepl2 Wdr77 Nup93 Nup50 Gemin6 Snrpf Gemin7 Nup35 Nup54 Nup98 Snrpg Gemin5 Snrpb Nup58 Gemin8 Nup37 Pom121 Prmt5 Nup205 Nup107 Sec13 Tgs1 Nup188 Tpr Smn1 Nup160 Rae1 Snupn Ndc1 Snrpd1 Clns1a Nup85 Nup42 Nup62 Nup43 Nup88 Gemin7l1 Aaas Snrpd3 Ranbp2 Nup214 Gemin2 PREDNISONE ADME%REACTOME%R-RNO-9757110.1 Prednisone ADME Cyp3a9 Akr1c18 Akr1c12l1 Akr1c19 Ugt1a2 Ugt1a3 Ugt1a5 Cyp3a18 Akr1c21 Abcb1 Ugt2b1 Hsd11b1 Hsd11b2 Ugt2b7 Cyp3a1 AC114845.1 Ugt2b34l1 Cyp3a62 Ugt2b Serpina6 Cyp3a2 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Alb Ugt2b17 Ugt2b37 Ugt2b15 Akr1c9 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%R-RNO-110330.1 Recognition and association of DNA glycosylase with site containing an affected purine Acd Terf1 Hist1h2ai Ogg1 H2aj Terf2ip Tinf2 H2ab2 Pot1 Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m Terf2 H2bc1 Neil3 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 96%10223411 Presynaptic depolarization and calcium channel opening Cacnb3 Cacnb4 Cacnb1 Cacna1e Cacnb2 Cacna1a Cacna1b Cacna2d3 Cacng4 Cacna2d2 Cacng2 CHYLOMICRON ASSEMBLY%REACTOME%R-RNO-8963888.1 Chylomicron assembly Sar1b Apoe Apoa4 P4hb Apob Mttp Apoc2 Apoa1 Apoc3 Apoa2 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-RNO-113418.1 Formation of the Early Elongation Complex Polr2j Ctdp1 Ncbp2 Ncbp1 Gtf2h2 Gtf2h1 Supt4h1 Gtf2f2 Gtf2f1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Nelfcd Mnat1 Ccnh Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe GPCR LIGAND BINDING%REACTOME%R-RNO-500792.1 GPCR ligand binding Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 App Ednrb Ednra Sct Rrh Ptgdr Htr4 Apln Trhr Tas2r39 Htr6 Oprd1 Htr7 Tas2r38 C3ar1 Crhbp Galr2 Galr3 Galr1 Cmklr1 Avpr2 Sstr5 Sstr4 Sstr3 Kel Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Rxfp1 Htr5a Ghrhr Tbxa2r Gpr183 Ppbp Fpr1 Gnrh1 Tas1r2 Tas1r1 Nmbr Fpr2 Ccr10 Tas1r3 C3 Vipr2 Nln Vipr1 C5 Ptgfr Pnoc Tas2r16 Tas2r13 Ppy Tas2r135 Tas2r136 Nmb Oxtr Lpar6 Xcr1 Gpr18 Grpr Gpr17 Nms Tas2r140 Nmu Tas2r145 Cckar Npbwr1 Fshb Gpbar1 Nmur2 Gnrhr Adm Nmur1 Ntsr2 Ntsr1 Tas2r4 Ramp1 Tas2r3 Brs3 Ptger4 Tas2r7 Gabbr1 Ptger2 Ptger3 Fshr Gabbr2 Ptger1 Ccr9 Ccr8 Ccr7 Ucn2 Mchr1 Ccr6 Ucn3 Ccr5 Crhr2 Ccr4 Crhr1 Ccr3 Gpr132 Edn1 Edn2 Edn3 Cckbr Gipr Mtnr1b Agtr1 Agtr2 F2 Gpha2 Gpr37 Calcrl Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Pth1r Taar3 Taar2 Avp Taar5 Rgr Taar1 Npb Gpr143 Grp Opn1mw Pth Kiss1r Gcgr Sctr Ccl19 Ccl17 Gphb5 Nps Mc4r Ccl11 Ccl12 Ptafr Npw Npy Ghrh Ptgdr2 Rho Pth2r Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Gpr4 Gcg Ptgdrl Ccl27 Npsr1 Prok1 Ramp3 P2ry10 Ramp2 Pdyn Mc3r P2ry13 P2ry12 Ccl20 Gng10-ps1 Gpr55 Ccl21 P2ry14 Adm2 F2rl1 Tas2r40 Fpr2l1 Tas2r41 Cd55 F2rl2 F2rl3 Hcar1 Prokr2 Adra2b Hcar2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Gpr65 Oprm1 Gpr68 Cxcr4 Cxcr5 Iapp Oprl1 Adrb2 Adrb1 Adra1b Adrb3 Adra1a Adra1d Lhcgr Gng3 Uts2 Mc5r Prlh Pomc Tacr1 Gng5 Tacr3 Gng4 Tacr2 Anxa1 Cxcl11 Gng7 Hebp1 Calcr Gng8 Gngt1 Cxcl12 Casr Cxcl10 C5ar2 F2r C5ar1 Ffar3 Aplnr Bdkrb2 Ffar1 Gnb2 Bdkrb1 Gnb1 Ffar2 Nts Gnb4 Kng1 Gnb3 Calcb Gnb5 Gng11 Chrm1 Calca Hrh1 Chrm3 Chrm2 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Gnas Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Ccrl2 Gper1 Oxgr1 Adra2a Opn5 Adora2b Sucnr1 Lhb Pyy Adora2a Cga Adora1 Adra2c Adora3 Rln3 Ltb4r2 Rln1 Cxcl16 Cxcl13 Ucn Tas2r119 Opn1sw Prlhr Oxt Ece1 Ece2 Trh P2ry2 Npy5r Adcyap1 Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Grm8 Htr2a Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Insl3 Gip Ptgir Psap Htr1d Htr1f Glp1r Crh Tas2r120 Xcl1 Htr1b Htr1a Agt Kiss1 Adgre5 Adgre1 Pth2 Tshr Glp2r Ccl9 P2ry6 Cxcl9 Ccl7 P2ry4 Ccl6 Ccl5 P2ry1 Ccl4 Ccl3 Ccl1 Cxcl1 Cxcl2 Cxcl3 Pthlh Cxcl5 Uts2b Tas2r105 Npffr1 Tas2r107 Npffr2 Gpr37l1 Npff Ackr3 Hcrtr2 Ackr4 Hcrtr1 Cck Qrfprl Cnr1 Qrfpr Ackr2 Qrfp Cnr2 Hcrt Uts2r Taar8c Sst Oprk1 Vip Tshb METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-RNO-2408508.1 Metabolism of ingested SeMet, Sec, MeSec into H2Se Scly Mat1a NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-RNO-9759194.1 Nuclear events mediated by NFE2L2 Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Crebbp Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Srxn1 Psmb6l1 Prdx1 Psmd7 Nfe2l2 Psmd6 Psmd8 Psmd2 Psma4 Prkaa2 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Ep300 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-RNO-76042.1 RNA Polymerase II Transcription Initiation And Promoter Clearance Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Mnat1 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Ccnh Taf7l-ps1 Gtf2a1 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Polr2c Taf4 Polr2a Taf2 Polr2b Taf1 Polr2g Gtf2e2 Polr2h Polr2e Polr2f Polr2i REGULATION OF BACH1 ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225359 Regulation of BACH1 activity Bach1 FCGR ACTIVATION%REACTOME%R-RNO-2029481.1 FCGR activation Lyn Yes1 Src Fyn ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Fgr Cd3g ENSRNOG00000065564 Hck ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 SPERM MOTILITY AND TAXES%REACTOME%R-RNO-1300642.1 Sperm Motility And Taxes Catsperd Catsper4 Catsper2 Catsperb Hvcn1 Catsper3 Catsper1 Kcnu1 Catsperg METHYLATION%REACTOME DATABASE ID RELEASE 96%10222323 Methylation Mtr Cyp1a2 As3mt Ahcy Comt Mtrr Gsto1 Tpmt Mat2a Mat2b Mat1a ERK1 ERK2 PATHWAY%REACTOME%R-RNO-5684996.1 ERK1 ERK2 pathway Il17rd Phb1 Erbb2 Erbb3 Ereg Paqr3 Wdr83 Araf Frs2 Prkcq Frs3 Btc Rasgrp4 Rasgrp1 Ranbp9 Tln1 Icmt Rasa2 Rasa1 Rasa4 Rasa3 Fn1 Pdgfa Pdgfb Rce1 ENSRNOG00000067432 Prkg2 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Brap Ret Spta1 Fgf17 Fgf18 Ptpra Pea15 Fgf19 Ncam1 Braf Sptb Sptbn1 Shoc2 Sptbn2 Mark3 Ptk2 Fgf10 Hbegf Mapk3 Mras Sptan1 Sptbn5 Artn Lypla1 Gfra1 Nras Sptbn4 Ralgdsl1 Grb2 Gfra2 Gfra4 Fyn Rap1a Kras Rap1b Sos1 Tyk2 Hras Bcl2l1 Tgfa Fgf20 Fgf23 Areg Kbtbd7 Fgf22 Kit Il6st Zdhhc9 Ppp2r5b Ppp2r5a Apbb1ip Golga7 Dusp2 Dusp5 Dusp1 Dab2ip Dusp9 Dusp8 Ppp1cc Ppp1cb Kitlg Cnksr2 Map2k2 Ppp2r5e Map2k1 Rapgef2 ENSRNOG00000069024 Map3k11 Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Dusp4 Fgf9 Lamtor3 Lamtor2 Dusp7 Hgf Dusp6 Egfr Vcl Shc3 Shc2 Pspn Arl2 Abhd17b Abhd17a Il6 Gdnf Pdgfrb Pdgfra Nf1 Il6r Rasgef1a Ralgds Rasgrf1 Rasgrf2 Fnta Abhd17c Fntb Nrtn Lat Kl Flt3 Ppp5c Ywhab Rasal1 Rasal2 Angpt1 Rasal3 Syngap1 Fgb Fga Ksr1 Fgg Nrg2 Itga2b Nrg3 Spred1 Met Spred3 Spred2 Dusp16 Ptpn7 Ptpn3 Csk Dusp10 Mapk12 Egf Pde6d Pebp1 Tek Itgb3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdk1 Mapk1 Ppp2cb Ppp2ca Calm3 Ppp2r5d Ppp2r1b Ppp2r1a Src Lrrc7 Camk2g Camk2d Camk2b Dlg1 Dlg2 Actn2 Dlg3 Dlg4 Camk2a Nefl Grin1 Grin2d Grin2b Arrb2 Arrb1 Raf1 Jak2 Pik3ca Shc1 Il2ra Il2rb Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Ptpn11 Irs2 Rbx1 Cul3 FRUCTOSE METABOLISM%REACTOME%R-RNO-5652084.1 Fructose metabolism Tkfc Aldh1a1 Glyctk Sord Aldob Akr1b1 Khk FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-RNO-163210.1 Formation of ATP by chemiosmotic coupling Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Dmac2l Atp5mg Atp5f1b Atp5f1a Atp5po Atp5mk Mt-atp8 Mt-atp6 Atp5mc1 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 96%10221925 Mitotic G1 phase and G1 S transition Ppp2cb Ppp2ca Rbbp4 Ppp2r1b Ppp2r1a Lyn Src Jak2 Pola2 Ccnh Pola1 Prim2 Prim1 Abl1 Ccnd2 Ccnd3 Ccnd1 Cdk7 Cdk6 Mnat1 Hdac1 Psma4 Ccna1 Akt3 Psma3 Akt2 Ccna2 Akt1 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Ppp2r3b Psmd11 Cdkn2b Cdkn2d Psmd14 Cdc25a Psmd13 Orc4 Orc6 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Gmnn Psmb5 Ptk6 Psmb4 Cdc7 Psmb7 Cdc6 Psmb6 Ppp2r2a Mcm7 Psmb1 Mcm8 Psmb3 Dbf4 Psmb2 Uba52 Dyrk1a Tfdp2 Tfdp1 Cks1b Cables1 Lin52 Rbl2 Lin54 Psma7 Rbl1 Mcm3 Mcm4 Mcm5 Psmc5 Mcm10 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Pole4 Lin9 Rpa1 Rpa2 Wee1 Lin37 Ubb Rpa3 E2f1 Ubc E2f2 E2f3 E2f4 Psmb6l1 E2f5 Cdkn1b Psmd7 Pole Rb1 Cdkn1c Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Cdk2 Cdk4 MTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222781 MTOR signalling Prkab2 Prkab1 Lamtor3 Lamtor2 Rptor RragB Fkbp1a Prkaa1 Ppm1a Eif4ebp1 Prkaa2 Mtor Stradb Akt3 Rps6kb1 Akt2 Rheb Akt1 Cab39 Strada Pgk1 Slc38a9 Lamtor5 Akt1s1 Prkag3 Lamtor4 Prkag1 Rraga Prkag2 Eef2k Tsc2 Lamtor1 Tsc1 Rragc Rragd Rps6 Stk11 Eif4e Ywhab Mlst8 Cab39l SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10225127 Selenocysteine synthesis Sephs2 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-RNO-5654712.1 FRS-mediated FGFR4 signaling Fgf16 Fgf17 Fgf18 Fgf19 Frs2 Frs3 Nras Grb2 Kras Klb Sos1 Hras Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf8 Fgfr4 Fgf9 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 96%10222979 Glutathione conjugation Gsta5 Gsta6 Gsta3 Gsta1 Gsta2 Chac1 Chac2 Gstm7 Gstm5 Gstk1 Ggct Gstm1 Gclc Gstm2 Mgst3 Gsto2 Esd Cndp2 Mgst2 Mgst1 Gclm Ggt1 Ggt5 Ggt7 Ggt6 Gstm4 Hpgds Gss Gstp1 Gstt2 Akr1a1 Gstt1 Oplah Gsto1 Gstz1 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 96%10223867 Smooth Muscle Contraction Tln1 Calm3 Myl12b Pxn Myl10 Pde5a Vcl Gucy1b1 Gucy1b2 Pak1 Itga1 Lmod1 Pak2 Tpm4 Tpm2 Cald1 Tpm1 Rlc-a Mylk Gucy1a1 Gucy1a2 Myl7 Myl11 Myl9 Sorbs3 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-RNO-72764.1 Eukaryotic Translation Termination Apeh TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-RNO-174417.1 Telomere C-strand (Lagging Strand) Synthesis Rpa1 Rpa2 Rpa3 Terf2 Lig1 Acd Terf1 Fen1 Rfc5 Terf2ip Pold2 Tinf2 Pold1 Rfc3 Pot1 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Chtf8 Blm Wrn Chtf18 Ctc1 Stn1 Ten1 Dscc1 Dna2 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-RNO-5693532.1 DNA Double-Strand Break Repair Blm Wrn Mapk8 Dna2 Rif1 Ppp4r2 Paxip1 Pias4 Ube2n Mre11 Ube2i Eme2 Kat5 Eme1 Timeless Nbn Gen1 Hus1 Atrip Lig3 Lig4 Sirt6 Rad51c Baz1b Rad51b Chek1 Chek2 Ube2v2 Rad9a Rad9b Bard1 Top3a Prkdc Palb2 Firrm Tp53 Ppp4c Lig1 Nhej1 Clspn Rad17 Kpna2 Fen1 Xrcc6 Parp2 Xrcc3 Parp1 Rfc5 Slx1b Pold2 Xrcc2 Pold1 Tdp2 Rfc3 Xrcc5 Rfc4 Pcna Tdp1 Xrcc4 Rfc1 Xrcc1 Atm Rfc2 Atr Bap1 Pold4 Tp53bp1 Pold3 Apbb1 Kdm4b Kdm4a Exo1 Mus81 Rmi2 Fignl1 Rmi1 Brip1 Abl1 Brcc3 ENSRNOG00000066901 Smarca5 Ppp5c Polq Herc2 Rnf168 Sumo1 ABRAXAS1 Polm Sumo3 Rnf8 Dclre1c Rhno1 Slx4 Nsd2 Spidr Rad51 Rad50 Rad52 Eya2 Eya1 Ercc1 Eya4 Ercc4 Babam1 Eya3 Babam2 Topbp1 Rbbp8 Ubxn1 Brca2 Brca1 Rad51ap1 Polk Hist1h2bq Uimc1 Poll Rad1 Polh Ccna1 Ccna2 Hist3h2ba Rps27a H2bc4 Hist1h4m H2bc1 Uba52 Pole3 Pole2 Pole4 Rpa1 Rpa2 Ubb Rpa3 Ubc Pole Cdk2 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 96%10224271 Molecules associated with elastic fibres Tgfb2 Tgfb3 Ltbp3 Ltbp2 Ltbp4 Fbln2 Ltbp1 Fbln5 Efemp2 Mfap4 Mfap5 Mfap2 Itgb8 Itgb6 Bmp7 Gdf5 Bmp4 Itgb1 Bmp2 Itgb3 Itga8 Itgav Bmp10 Vtn Tgfb1 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 96%10223389 Metabolism of amine-derived hormones Duox1 Tph1 Ddc Pnmt Duoxa1 Duoxa2 Cav1 Asmt Txndc11 Dio1 Dio2 Dio3 Dbh Cga Duox2 Tpo Th Iyd Slc5a5 Tshb Aanat Tph2 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-RNO-68949.1 Orc1 removal from chromatin Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Orc4 Orc6 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Psmb5 Psmb4 Psmb7 Psmb6 Cdc6 Mcm7 Psmb1 Mcm8 Psmb3 Psmb2 Uba52 Psma7 Mcm3 Mcm4 Mcm5 Psmc5 Psmc2 Mcm2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 96%10225423 Regulation of MITF-M-dependent genes involved in apoptosis Sin3a Hint1 Mitf Hdac1 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-RNO-9023661.1 Biosynthesis of E-series 18(R)-resolvins Gpx4 Alox5 Lta4h Alox15 CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 96%10221977 Cell Cycle Checkpoints Ywhag Spdl1 Nup133 Zfp385a Bub1 Itgb3bp Gsk3b Gtse1 Zwilch Ppp2r5b Ppp2r5a Ube2n Ppp1cc Fbxw11 Ppp2r5e Mapk14 Mapk11 Ywhab Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Ccne1 Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Cdc25a Psmd13 Cdc27 Orc4 Cdc26 Orc6 Cdc23 Orc1 Orc3 Skp1 Orc2 Cdc20 Psmb5 Psmb4 Cdc7 Psmb7 Cdc6 Psmb6 Ccnb1 Psmb1 Mcm7 Psmb3 Mcm8 Psmb2 Dbf4 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Mcm3 Mcm4 Aurkb Psmc5 Mcm5 Psmc2 Mcm10 Psmc1 Mcm2 Psmc4 Psmc3 Anapc5 Rpa1 Anapc4 Rpa2 Anapc1 Anapc2 Wee1 Rpa3 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Cdkn1b Psmd7 Ywhae Psmd6 Psmd8 Plk1 Psmd2 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 Ppp2cb Ppp2ca Ppp2r5d Ppp2r1b Ppp2r1a Blm Wrn Dna2 Pias4 Mre11 Kat5 Nbn Hus1 Atrip Chek1 Chek2 Ube2v2 Rad9a Rad9b Bard1 Top3a Tp53 Clspn Rad17 Rfc5 Rfc3 Rfc4 Atm Rfc2 Atr Tp53bp1 Exo1 Rmi2 Rmi1 Brip1 Brcc3 ENSRNOG00000066901 Herc2 Rnf168 ABRAXAS1 Rnf8 Rhno1 Nsd2 Rad50 Babam1 Babam2 Topbp1 Rbbp8 Brca1 Hist1h2bq Uimc1 Rad1 Hist3h2ba Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Sfn Rps27 H2bc4 Plk3 Hist1h4m Rcc2 H2bc1 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Phf20 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Csnk1a1 B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Pkmyt1 Clip1 Sgo2 Sgo1 Nup107 Cdc25c Sec13 Kif2a Rbx1 Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Cop1 Mdm4 Ndc80 Nup43 Ywhaq Ywhah Birc5 Ercc6l Ccnb2 Ranbp2 Ckap5 Csnk1e Ywhaz ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-RNO-2730905.1 Role of LAT2 NTAL LAB on calcium mobilization Pdpk1 ENSRNOG00000070986 Lat2 Pik3ca Shc1 Gab2 Lyn Pik3r1 Pik3cb Pik3r2 Grb2 Sos1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-RNO-9025106.1 Biosynthesis of DPAn-6 SPMs Alox12 Alox15 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 96%10223319 TCF dependent signaling in response to WNT Ppp2cb Ppp2ca Gsk3b Ctnnb1 Sox3 Wnt5a Sox9 Sox7 Sox6 Pygo2 Sox4 Pygo1 Men1 Tle4 Tle3 Tle2 Tle1 Tnks2 Ppp2r5d Hecw1 Xiap Klhl12 Axin1 Axin2 Rnf43 Tcf7 Dvl1 Dvl2 Dvl3 Sox13 Tcf7l1 Wnt1 Tcf7l2 Fzd1 Fzd2 Ppp2r1b Fzd5 Ppp2r1a Fzd4 Fzd6 Sox17 Fzd8 Bcl9l Bcl9 Cdc73 Rnf146 Cby1 Znrf3 Ctbp1 Amer1 Tnks Rspo1 Rspo3 Rspo2 Rspo4 Usp34 Tert Chd8 Wnt8b Smurf2 Wnt8a Sry3 Ppp2r5b Lef1 Ppp2r5a Dact1 Sry Leo1 Ryk Ctnnbip1 Apc Lgr5 Lgr6 Frat2 Pip5k1b Frat1 Ppp2r5e Crebbp Kmt2b Csnk2a2 Csnk2a1 Dkk4 Kremen2 Kremen1 Hdac1 Wdr5 Lrp6 Ash2l Sost Dkk1 Dkk2 Csnk2b Cav1 Psma4 Smarca4 Psma3 Akt2 Akt1 Psma6 Ep300 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Rbbp5 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Xpo1 Psmb2 Uba52 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul3 Csnk1e Ywhaz REGULATION OF CDH1 FUNCTION%REACTOME%R-RNO-9764561.1 Regulation of CDH1 Function Ctnnb1 Ctsl Psma4 Psma3 Psma6 Src Psma5 Psma2 Psma1 Rps27a Psmd12 Fyn Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Ctsb Cbll1 Ctss Cdh1 Psmc5 Ctnna1 Psmc2 Rack1 Psmc1 Eps15 Psmc4 Dnm2 Psmc3 Jup Mtbp Ctnnd1 Banp Ubb Ubc Psmb6l1 Psmd7 Vcl Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-RNO-159230.1 Transport of the SLBP Dependant Mature mRNA Nup133 Nup210 Ncbp2 Nup155 Ncbp1 Nup153 Nup93 Nup50 Alyref Nxf1 Slbp Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Eif4e Ranbp2 Nup214 INFLAMMASOMES%REACTOME%R-RNO-622312.1 Inflammasomes Nlrp3 Txn Mefv Pstpip1 Nlrp1a Hsp90ab1 Aim2 P2rx7 Bcl2l1 Pycard Panx1 Txnip Sugt1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-RNO-936440.1 Negative regulators of RIG-I MDA5 signaling Rps27a Uba52 Tbk1 Irf3 Mavs Rig1 Ubb Tax1bp1 Ikbke Ubc Cyld Nlrx1 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-RNO-1638074.1 Keratan sulfate keratin metabolism Omd Chst1 Chst3 Chst2 B4galt2 B4galt3 Acan Chst6 Ogn St3gal6 St3gal4 St3gal2 St3gal3 St3gal1 Glb1 Slc35d2 Glb1l B3gnt7 B3gnt2 Kera Gns B4galt4 B4galt5 B4galt6 Prelp Glb1l3 Glb1l2 Fmod Galns Hexa Hexb B3gnt3 B4gat1 Lum PI3K EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224157 PI3K events in ERBB2 signaling Egfr Pik3ca Erbb2 Erbb3 Ereg Nrg2 Nrg3 Hbegf Btc Pik3r1 Grb2 Egf Gab1 TRKA ACTIVATION BY NGF%REACTOME%R-RNO-187042.1 TRKA activation by NGF Ntrk1 Ngf JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 96%10222873 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ikbkg Map3k7 Ube2n Irak2 Irak1 Tab3 Tab2 Tab1 Nod2 Mapk9 Nod1 Mapk10 Map2k7 Mapk8 Traf6 Ripk2 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 96%10224765 Phospholipase C-mediated cascade; FGFR4 Fgf16 Fgf17 Fgf18 Fgf19 Plcg1 Klb Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf8 Fgfr4 Fgf9 ACYL CHAIN REMODELLING OF PI%REACTOME%R-RNO-1482922.1 Acyl chain remodelling of PI Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4a Pla2g4d Plbd1 Pla2r1 Pla2g12a Mboat7 Pla2g10 Plaat3 Pla2g5 EPHRIN SIGNALING%REACTOME%R-RNO-3928664.1 Ephrin signaling Ephb1 Ephb2 Ephb3 Ephb4 Ephb6 Nck2 Pak1 Rac1 Pak3 Git1 Pak2 Src Rlc-a Fyn Sdcbp Efnb1 Arhgef7 Efnb2 Efnb3 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-RNO-9006931.1 Signaling by Nuclear Receptors Ereg Pdpk1 Akr1c18 Akr1c12l1 Akr1c19 Btc Akr1c21 Gnai2 Gnai1 Gnai3 Tle3 Calm3 Akr1c3l1 Akr1c12 S1pr3 Akr1c1 Akr1c13 Akr1c9 Creb1 Gnat3 Ptk2 Mapk3 Hbegf Src Nras Kras Polr2c Hras Polr2a Tgfa Polr2b Polr2g Atf2 Polr2h Areg Polr2e Polr2f Polr2i Polr2j Kat5 Gtf2f2 Gtf2f1 Fos Egfr Hsp90ab1 H2ab2 Jun H2ac4 Kdm4b Gata3 ENSRNOG00000066901 Ppp5c Cbfb Esr1 Crebbp H2ac18 Egf Aldh1a1 Hist1h2bq Prmt1 Hdac1 Pik3ca H2aj Shc1 Cav1 Dhrs4 Pdhx Akt3 Tbp H3-3b Dhrs3 Akt2 Aldh1a2 Akt1 Hist3h2ba Aldh1a3 Gtf2a1 Pik3r1 Ep300 Nrip1 Gtf2a2 Hsp90aa1 ENSRNOG00000068602 Cyp26b1 Pdk4 Pik3r2 Pdk3 Pik3r3 Dhrs9 Ppid Uhmk1 Pdk2 Sdr16c5 H2bc18 Ppidl1 Runx1 Pdk1 Kat2b Nr1h3 H2az2 Nr1h2 Pdhb H2bc4 Kdm1a Hist1h4m Rxrb H2bc1 Rxra Cyp26a1 Sphk1 Hist1h2ai Zdhhc7 Pgr Rxrg Xpo1 Rdh11 Rdh10 Tbl1x Rdh13 Rdh14 Adh4 Pdha1 Adh1 Pdha2 Greb1 Cited1 Strn Prkcz Cav2 Esr2 Abca1 Cdk9 Crabp1 Crabp2 Igf1r Rdh7 Hdac3 Pou2f1 Tbl1xr1 Rara Foxo3 Mmp7 Mmp2 Mmp3 Cdkn1b Zdhhc21 Ppard Fkbp4 Mmp9 Fkbp5 Ptges3 Dld Ncor2 Carm1 Aldh8a1 Gps2 Zfp217 Foxa1 Ncoa3 Rarg Mapk1 Nos3 Fabp5 Yy1 Cyp26c1 Dlat Nr5a2 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 96%10221933 Polymerase switching Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 96%10225277 Signaling by NOTCH4 Notch4 Akt1 Ywhaz TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 96%10224195 Tandem pore domain halothane-inhibited K+ channel (THIK) Kcnk13 P75NTR REGULATES AXONOGENESIS%REACTOME DATABASE ID RELEASE 96%10223183 p75NTR regulates axonogenesis Ngfr Mag Ngf Mcf2 Omg Arhgdia Rhoa Rtn4 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223365 ER to Golgi Anterograde Transport Lman1 Scfd1 Actr1a Lman2 Ins2 Sec22a Dctn1 Tfg Dctn2 Cog1 Cog2 Rab1A Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Cog6 Cog7 Cog8 Napa Nsf Napb Ank1 Napg Sec23a Tmem115 Kdelr2 Kdelr3 Sec23ip Sec16b Sec16a Spta1 Lman2l Copa Bet1l Cnih1 Gorasp1 Cnih3 Sptb Cnih2 Sptbn1 Sptbn2 Kdelr1 Arf4 Ctsc Arf3 Sptan1 Sptbn5 Arf1 Ppp6r3 Mia2 Sptbn4 Mia3 Sar1b Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Col7a1 Tgfa Ppp6c Sec31b Gria1 Areg Sec31a F8 Stx17 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 Ctsz Rab1b Trappc2l Dync1h1 Trappc10 Dync1i2 Dync1i1 Sec13 Trappc6b Dync1li2 Trappc6a Trappc9 Dync1li1 Trappc5 Dynll1 Trappc4 Dynll2 Trappc3 Trappc2 Trappc1 Ins1 Cd55 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223669 Hormone ligand-binding receptors Fshb Gnrh1 Fshr Gnrhr Gphb5 Lhcgr Lhb Cga Gpha2 Tshr Tshb SUCCINYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222105 Succinyl-CoA Biosynthesis Dld AC132020.1 Ogdh Dlst Kgd4 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 96%10223631 Metabolism of cofactors Idh1 Pdss2 Coq8a Pdss1 Coq8b Coq2 Pts Coq3 Gchfr Coq4 Coq5 Coq6 Hpdl Akt1 Coq7 Spr Hsp90aa1 Coq9 Stard7 Nos3 Aco1 Calm3 Prkg2 Gch1 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 96%10222253 Formation of editosomes by ADAR proteins Adarb1 Adar CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%10222895 Cyclin A B1 B2 associated events during G2 M transition Ccnb1 Ppp2r2a Ppp2cb Xpo1 Ppp2ca Cdk7 Mnat1 Wee1 Fzr1 Pkmyt1 Plk1 Ppp2r1b Sgo1 Ppp2r1a Ccna1 Cdc25c Ccna2 Ccnh Cdk2 Cdk1 Ppp2r3b Bora Foxm1 Ppme1 Cdc25a Lcmt1 Ccnb2-ps2 Mis18bp1 Hjurp Cdc25b Obi1 Ccnb2 Ticrr INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223901 Interleukin-4 and Interleukin-13 signaling Stat6 Il13 Hsp90b1 Socs5 Jak2 Il4 Stat3 Stat1 Jak3 Tyk2 Socs1 Il13ra2 Il4r RAF MAP KINASE CASCADE%REACTOME DATABASE ID RELEASE 96%10224791 RAF MAP kinase cascade Il17rd Phb1 Erbb2 Erbb3 Ereg Paqr3 Wdr83 Araf Frs2 Prkcq Frs3 Btc Rasgrp4 Rasgrp1 Ranbp9 Tln1 Icmt Rasa2 Rasa1 Rasa4 Rasa3 Fn1 Pdgfa Pdgfb Rce1 ENSRNOG00000067432 Prkg2 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Brap Ret Spta1 Fgf17 Fgf18 Ptpra Pea15 Fgf19 Ncam1 Braf Sptb Sptbn1 Shoc2 Sptbn2 Mark3 Ptk2 Fgf10 Hbegf Mapk3 Mras Sptan1 Sptbn5 Artn Lypla1 Gfra1 Nras Sptbn4 Ralgdsl1 Grb2 Gfra2 Gfra4 Fyn Rap1a Kras Rap1b Sos1 Hras Bcl2l1 Tgfa Fgf20 Fgf23 Areg Kbtbd7 Fgf22 Kit Zdhhc9 Ppp2r5b Ppp2r5a Apbb1ip Golga7 Dusp2 Dusp5 Dusp1 Dab2ip Dusp9 Dusp8 Ppp1cc Ppp1cb Kitlg Cnksr2 Map2k2 Ppp2r5e Map2k1 Rapgef2 ENSRNOG00000069024 Map3k11 Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Dusp4 Fgf9 Lamtor3 Lamtor2 Dusp7 Hgf Dusp6 Egfr Vcl Shc3 Shc2 Pspn Arl2 Abhd17b Abhd17a Gdnf Pdgfrb Pdgfra Nf1 Rasgef1a Ralgds Rasgrf1 Rasgrf2 Fnta Abhd17c Fntb Nrtn Lat Kl Flt3 Ppp5c Ywhab Rasal1 Rasal2 Angpt1 Rasal3 Syngap1 Fgb Fga Ksr1 Fgg Nrg2 Itga2b Nrg3 Spred1 Met Spred3 Spred2 Dusp16 Ptpn7 Ptpn3 Csk Dusp10 Mapk12 Egf Pde6d Pebp1 Tek Itgb3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Mapk1 Ppp2cb Ppp2ca Calm3 Ppp2r5d Ppp2r1b Ppp2r1a Src Lrrc7 Camk2g Camk2d Camk2b Dlg1 Dlg2 Actn2 Dlg3 Dlg4 Camk2a Nefl Grin1 Grin2d Grin2b Arrb2 Arrb1 Raf1 Jak2 Pik3ca Shc1 Il2ra Il2rb Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Irs2 Rbx1 Cul3 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-RNO-2534343.1 Interaction With Cumulus Cells And The Zona Pellucida Hyal5 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 96%10224701 Matriglycan biosynthesis on DAG1 Fktn Pomgnt1 Slc35a1 Chst10 Fkrp Slc35a4 Rxylt1 Crppa Dag1 B4gat1 Large1 Large2 SWI SNF CHROMATIN REMODELERS%REACTOME%R-RNO-9932451.1 SWI SNF chromatin remodelers Smarcc1 Ss18 Dpf1 Bicral Bicra Dpf2 Dpf3 Pbrm1 Brd9 Brd7 Actg1 Ss18l1 Smarcb1 Bcl7a Bcl7b Bcl7c Bcl11a Bcl11b Phf10 Smarca2 Arid1a Smarca4 Arid1b Actl6a Smarcd1 Smarce1 Smarcd3 Smarcd2 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190241.1 FGFR2 ligand binding and activation Fgf16 Fgfbp3 Fgf17 Fgfbp1 Fgf18 Fgf10 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgf7 Fgf9 Fgfr2 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-RNO-193704.1 p75 NTR receptor-mediated signalling Itgb3bp Ngf Arhgef7 Tiam1 Mcf2l Tiam2 Rac1 Prkci Adam17 Bcl2l11 Arhgef15 Arhgef17 Arhgef16 Sqstm1 Arhgef11 Rhoa Arhgef10 Arhgef12 Ngef Arhgef19 Rps27a Vav3 Akap13 Vav1 Vav2 Sos1 Itsn1 Arhgef26 Arhgef25 Psenen Psen1 Ikbkb Psen2 Sos2 Kalrn Ncstn Mapk8 Aph1a Traf6 Bex3 Arhgef6 Aph1b Arhgef5 Arhgef4 Arhgef2 Uba52 Gna13 Arhgef1 Nfkb1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Rela Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Casp3 Casp2 Plekhg5 Myd88 Plekhg2 Ubb Net1 Arhgef10l Ubc Ripk2 Ywhae Irak1 Nfkbia Rasgrf2 Ngfr Mag Mcf2 Omg Arhgdia Rtn4 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223119 Gap junction degradation Cltb Myo6 Cltc Dab2 Dnm1 Dnm2 Ap2m1 Gja1 Clta P75NTR SIGNALS VIA NF-KB%REACTOME%R-RNO-193639.1 p75NTR signals via NF-kB Uba52 Prkci Nfkb1 Irak1 Ngf Nfkbia Sqstm1 Rela Rps27a Ngfr Myd88 Ikbkb Ubb Ubc Traf6 Ripk2 PERK REGULATES GENE EXPRESSION%REACTOME%R-RNO-381042.1 PERK regulates gene expression Eif2ak3 Eif2s3 Eif2s2 Eif2s1 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-RNO-8850843.1 Phosphate bond hydrolysis by NTPDase proteins Entpd1 Entpd2 Entpd5 Entpd6 Entpd3 Entpd4 Entpd7 Entpd8 INTERLEUKIN-6 SIGNALING%REACTOME%R-RNO-1059683.1 Interleukin-6 signaling Jak2 Tyk2 Stat3 Ptpn11 Stat1 Il6 Socs3 Il6st Cbl Il6r MAPK FAMILY SIGNALING CASCADES%REACTOME DATABASE ID RELEASE 96%10222403 MAPK family signaling cascades Il17rd Phb1 Erbb2 Erbb3 Ereg Paqr3 Wdr83 Araf Frs2 Prkcq Frs3 Btc Rasgrp4 Rasgrp1 Ranbp9 Tln1 Icmt Rasa2 Rasa1 Rasa4 Rasa3 Fn1 Pdgfa Pdgfb Rce1 ENSRNOG00000067432 Prkg2 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Brap Ret Spta1 Fgf17 Fgf18 Ptpra Pea15 Fgf19 Ncam1 Braf Sptb Sptbn1 Shoc2 Sptbn2 Mark3 Ptk2 Fgf10 Hbegf Mapk3 Mras Sptan1 Sptbn5 Artn Lypla1 Gfra1 Nras Sptbn4 Ralgdsl1 Grb2 Gfra2 Gfra4 Fyn Rap1a Kras Rap1b Sos1 Tyk2 Hras Bcl2l1 Tgfa Fgf20 Fgf23 Areg Kbtbd7 Fgf22 Kit Il6st Zdhhc9 Ppp2r5b Ppp2r5a Apbb1ip Golga7 Dusp2 Dusp5 Dusp1 Dab2ip Dusp9 Dusp8 Ppp1cc Ppp1cb Kitlg Cnksr2 Map2k2 Ppp2r5e Map2k1 Rapgef2 ENSRNOG00000069024 Map3k11 Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Dusp4 Fgf9 Lamtor3 Lamtor2 Dusp7 Hgf Dusp6 Egfr Vcl Shc3 Shc2 Pspn Arl2 Abhd17b Abhd17a Il6 Gdnf Pdgfrb Pdgfra Nf1 Il6r Rasgef1a Ralgds Rasgrf1 Rasgrf2 Fnta Abhd17c Fntb Nrtn Lat Kl Flt3 Ppp5c Ywhab Rasal1 Rasal2 Angpt1 Rasal3 Syngap1 Fgb Fga Ksr1 Fgg Nrg2 Itga2b Nrg3 Spred1 Met Spred3 Spred2 Dusp16 Ptpn7 Ptpn3 Csk Dusp10 Mapk12 Egf Pde6d Pebp1 Tek Itgb3 Rac1 Pak3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Foxo3 Psmb6l1 Cdc14a Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdk1 Ncoa3 Mapk1 Ppp2cb Ppp2ca Prkaca Prkacb Calm3 Ppp2r5d Pak1 Ppp2r1b Ppp2r1a Pak2 Src Lrrc7 Camk2g Camk2d Camk2b Dlg1 Dlg2 Actn2 Dlg3 Dlg4 Camk2a Nefl Grin1 Grin2d Grin2b Arrb2 Arrb1 Raf1 Jak2 Ccnd3 Pik3ca Shc1 Il2ra Il2rb Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Ptpn11 Kalrn Irs2 Xpo1 Rbx1 Foxo1 Septin7 Mapk6 Mapk4 Cdc42ep2 Cdc42ep3 Hspb1 Cdc14b Etv4 Cdc42 Dnajb1 Cul3 Mapkapk5 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 96%10223201 Transport of organic anions Slco2b1 Slco2a1 Slco4c1 SLC16A2 Slco1c1 Avp Slco3a1 Slco1a4 Slco4a1 Slco1b2 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%10225125 Protein localization Phyh Amacr Eci2 Mpv17 Hmox1 Gstk1 Hacl1 Pex26 Sec61gl4 Mlycd Scp2 Pex11b Gnpat Crat Acox1 Acox2 Ech1 Ehhadh Acox3 Ube2d3 Ube2d2 Pipox Acaa1b Tysnd1 Prnp Hsd17b4 Lonp2 Pxmp4 Pxmp2 Hao1 Hao2 Fis1 Pecr Stx1a Dao Acbd5 Pitrm1 Slc27a2 Aldh3a2 Ide Decr2 Crot Emd Hspd1 Nudt19 Acot1 Acot2 Pex2 Pex1 Acot5 Vamp2 App Acot3 Acot4 Cyb5a Ldhd Pex7 Usp9x Acot8 Pex3 Pex6 Pex5 Cat Fxn Serp1 Sgta Abcd1 Baat Ddo Abcd2 Gdap1 Abcd3 Zfand6 Vapa Agps Stx5 Agxt Nudt7 Hmgcl Nos2 Hscb Ndufb8 Atad1 Pex14 Pex13 Pex12 Pex10 Pex19 Ube2j2 Otc Pex16 Idh1 Coq2 Atp5mc3 Dhrs4 Atp5f1b Rps27a Uba52 Ube2d1 Ephx2 Ubb Ubc DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 96%10221905 DNA Replication Pre-Initiation Kpnb1 Kpna6 Kpna1 H2ab2 Pola2 H2ac4 Pola1 Prim2 Prim1 ENSRNOG00000066901 H2ac18 Hist1h2bq H2aj Psma4 Psma3 H3-3b Ube2s Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Orc4 H2bc18 Cdc26 Orc6 Cdc23 Orc1 Orc3 H2az2 Orc2 Cdt1 H2bc4 Gmnn Psmb5 Hist1h4m Psmb4 H2bc1 Cdc7 Psmb7 Cdc6 Psmb6 Hist1h2ai Mcm7 Psmb1 Mcm8 Psmb3 Dbf4 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Mcm10 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Anapc5 Pole4 Anapc4 Rpa1 Anapc1 Rpa2 Anapc2 Fzr1 Ubb Rpa3 Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Pole Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdk2 Cdc16 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-RNO-350054.1 Notch-HLH transcription pathway Kat2a Maml3 Rbpj Hdac2 Hdac5 Hdac4 Maml1 Tbl1x Hdac11 Crebbp Maml2 Ncor2 Hdac10 Notch3 Hdac9 Hdac8 Notch4 Kat2b Hdac3 Tbl1xr1 Hdac1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%10224049 IRAK2 mediated activation of TAK1 complex Rps27a Tab3 Tab2 Map3k7 Uba52 Tab1 Irak2 Ubb Ubc Traf6 RECYCLING PATHWAY OF L1%REACTOME%R-RNO-437239.1 Recycling pathway of L1 Cltc Dnm1 Dpysl2 Src Kif4b Ap2s1 Kif4a Rdx Mapk1 Msn L1cam Dnm2 Dnm3 Ap2a2 Ap2a1 Ap2b1 Numb Sh3gl2 Ezr Ap2m1 Clta BILE ACID AND BILE SALT METABOLISM%REACTOME%R-RNO-194068.1 Bile acid and bile salt metabolism Osbpl6 Cyp39a1 Osbpl9 Hsd3b7 Ncoa2 Akr1d1 Amacr Baat Cyp8b1 Akr1c18 Cyp7b1 Akr1c12l1 Slc10a1 Akr1c19 Fabp6 Nr1h4 Abcc3 Stard5 Akr1c21 Cyp46a1 Scp2 Cyp27a1 Osbp Slc27a5 Slc51a Cyp7a1 Acox2 Slc51b Abcb11 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Alb Hsd17b4 Akr1c9 Slc27a2 Ch25h Osbpl3 Slco1a4 Osbpl2 Acot8 Osbpl1a Osbpl7 Slco1b2 Rxra COMPLEMENT CASCADE%REACTOME%R-RNO-166658.1 Complement cascade Cpb2 Fcn2 Fcn1 Cr2 Serping1 Cr1l Clu Mbl2 Cd81 Masp1 Masp2 C4b C1qb Crp C1qa Cfh Cfi C2 C5ar2 Elane C4 C5ar1 Colec10 C6 C9 Cd46 Cfhr1 C1s C1r Cpn1 Cpn2 Cd19 C1qc ENSRNOG00000069193 AABR07065813.1 F2 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 C3ar1 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 C3 C5 Cd55 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10223781 NoRC negatively regulates rRNA expression Hist1h2ai H2aj H2ab2 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Mbd2 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m H2bc1 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-RNO-1855191.1 Synthesis of IPs in the nucleus Ippk Ipmk Ip6k1 Ip6k2 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-RNO-1660516.1 Synthesis of PIPs at the early endosome membrane Fig4 Vac14 Mtmr12 Pi4k2a Mtmr4 Pik3r4 Inpp5f Pi4k2b Inpp4a Pikfyve Inpp4b Pik3c2a Pik3c3 Mtm1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 96%10224891 Protein lipoylation Dlat Gcsh Lipt1 Lipt2 Nfu1 Ndufab1 Fdx1 Dbt Dlst Lias MICRORNA (MIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223413 MicroRNA (miRNA) biogenesis Ago3 Ago2 Ago1 Dicer1 Tarbp2 Prkra Ago4 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%10224331 IPs transport between nucleus and cytosol Nup133 Nup210 Nup155 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME%R-RNO-69052.1 Switching of origins to a post-replicative state Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Orc4 Cdc26 Orc6 Cdc23 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Psmb5 Gmnn Psmb4 Psmb7 Psmb6 Cdc6 Mcm7 Psmb1 Mcm8 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Psmc2 Mcm2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdc16 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222291 Wax and plasmalogen biosynthesis Gnpat Awat2 Awat1 Dhrs7b Far2 Far1 Agps ECM PROTEOGLYCANS%REACTOME%R-RNO-3000178.1 ECM proteoglycans Acan Itga2b Itgb6 Itgb1 Itgb3 Tnc Itga7 Itgax Dmp1 Itga9 Dspp Bcan Vcan Tnn Itga2 Tnr Agrn Tnxb Ncan Dcn Hapln1 Serpine1 Itga8 Itgav Vtn FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10222325 Fatty acids Cyp2j16 Adh7 Cyp4f39 Cyp2j3 Cyp4f1 Cyp4a14 Cyp2f2 Cyp4f3 Cyp4a12 Cyp4f40 Cyp2d4 Cyp4b1 Cyp2a2 Cyp2a1 Cyp4f4 Cyp4a10 Cyp4a2 Cyp2a3 ARMS-MEDIATED ACTIVATION%REACTOME%R-RNO-170984.1 ARMS-mediated activation Rap1a Ntrk1 Ngf Crk Kidins220 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190372.1 FGFR3c ligand binding and activation Fgf16 Fgf17 Fgf18 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Galnt3 Fgf9 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 96%10224953 Retrograde transport at the Trans-Golgi-Network Rab43 Tmf1 Sys1 Golga1 Vps51 Vps52 Vps54 Arl1 Rab9a Gcc2 Rab9b Gcc1 Cog1 Usp6nl Cog2 Stx6 Cog3 Ttgn1 Ric1 Cog4 Igf2r Scoc M6pr Vti1a Cog5 Vamp3 Vamp4 Cog6 Stx16 Cog7 Rgp1 Arfip2 Cog8 Rhobtb3 Napa Rabepk Nsf Arfrp1 Napb Napg Rab6b Rab6a Golga4 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%10222121 Pyrophosphate hydrolysis Ppa1 Ppa2 Lhpp PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 96%10224671 Phase 3 - rapid repolarisation Kcne3 Kcne2 Kcnh2 Kcna5 Akap9 Kcne5 Kcnq1 Kcne4 INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 96%10224095 Inwardly rectifying K+ channels Gng3 Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Kcnj8 Gabbr2 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Kcnj1 Kcnj14 Gnb2 Abcc8 Gnb1 Kcnj11 Kcnj12 Gnb4 Gnb3 Abcc9 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-RNO-5358493.1 Synthesis of diphthamide-EEF2 Dph5 Dph6 Eef2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-RNO-1474151.1 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Nos3 Calm3 Pts Gchfr Prkg2 Akt1 Spr Gch1 Hsp90aa1 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-RNO-3214858.1 RMTs methylate histone arginines Smarcc1 Hist1h2ai Ccnd1 Wdr77 Rbbp7 H2ac18 Pbrm1 Prmt6 Prmt1 Smarcb1 Wdr5 Prmt5 Smarca2 Arid1a Smarca4 Arid1b Carm1 H2ac4 ENSRNOG00000068602 Actl6a Smarcd1 Actl6b Smarce1 Smarcd3 Smarcd2 Coprs H2ac25 H2bc18 Prmt7 Dnmt3a Prmt3 Cdk4 Rps2 Hist1h4m THREONINE CATABOLISM%REACTOME%R-RNO-8849175.1 Threonine catabolism Rida Sds Sdsl PHOSPHORYLATION OF EMI1%REACTOME%R-RNO-176417.1 Phosphorylation of Emi1 Ccnb1 Plk1 Fbxo5 Fzr1 Cdc20 Cdk1 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%10225051 Regulation of Apoptosis Oma1 Opa1 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223935 Activation of Na-permeable kainate receptors Grik2 Grik1 SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 96%10224455 Scavenging by Class A Receptors Apoe Hsp90b1 Msr1 Calr Apob Apoa1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-RNO-9840310.1 Glycosphingolipid catabolism Arsa Smpd2 Neu2 Smpd3 Neu3 Smpd4 Neu4 Smpd1 Neu1 Gba1 Gba3 Gba2 Enpp7 Galc Asah2 M6pr Asah1 Sts Gm2a Arsl Arsk Arsj Arsi Arsg Gla Sumf1 Glb1 Arsb Sumf2 Ctsa Glb1l Psap Glb1l3 Glb1l2 Hexa Hexb OPSINS%REACTOME%R-RNO-419771.1 Opsins Opn1mw Rho Rrh Opn4 Opn3 Opn1sw Opn5 Rgr CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-446728.1 Cell junction organization Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Xiap Pxn Src Fyn Ctbp1 Tyk2 Il6st Nfkb1 Ctsb Cbll1 Rela Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Pard3 Mogs Nectin1 Angptl4 Cdh9 Nectin2 Pvr Cdh8 Vcl Hdac2 Jak2 Nectin4 Cdh7 Cdh6 H2ab2 Cdh3 Cdh2 Twist1 Pard6b Il6 Pard6a Kmt5a H2ac4 Sec11c Amot Sec11a Il6r Fermt2 Prkcsh Flna Flnc Sirt1 Pard6g Vasp Itga6 Zmym2 Cadm3 Sp1 ENSRNOG00000066901 Cdh24 Cadm2 Cadm1 Rnf19b Tesk1 F11r Pomt1 Sdk1 Hace1 Dnttip1 Pomt2 Stat3 Fblim1 Furin Parvb Parva Pcsk7 Pcsk6 Sdk2 Ilk Birc2 H2ac18 Adam19 Afdn Ctbp2 Plec Csnk2a2 Dst Ang2 Ctsl Zeb1 Csnk2a1 Zeb2 Cdh18 Itgb1 Cdh17 Cd151 Cdh15 Hist1h2bq Itgb4 Cdh13 Cdh12 Hdac1 Actn1 Cdh11 Cdh10 Ganab Csnk2b Mphosph8 Megf11 H2aj Canx Tiam1 Arhgap32 Spcs3 Prkci Rac1 Spcs1 Spcs2 Psma4 Smarca4 Farp2 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Vav2 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Arhgef6 Psmb6 Hist1h2ai Psmb1 Arhgef4 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Cdc42 Ezh2 Dad1 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 96%10222743 Attachment of GPI anchor to uPAR Pgap1 Pigs Pigu Pigt Gpaa1 Pigk Plaur DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 96%10223321 Disassembly of the destruction complex and recruitment of AXIN to the membrane Ppp2r5b Ppp2r5a Ppp2cb Ppp2ca Gsk3b Apc Ctnnb1 Frat2 Frat1 Csnk1a1 Ppp2r5e Ppp2r5d Axin1 Lrp6 Dvl1 Dvl2 Dvl3 Wnt1 Fzd1 Cav1 Fzd2 Ppp2r1b Fzd5 Ppp2r1a Amer1 Wnt8b Wnt8a EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-RNO-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes Ncoa2 Kmt2d Crebbp Kmt2a Kmt2b Kmt2c H2ac18 Men1 Hist1h2bq Wdr5 Ash2l H2aj Cdk5 H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Med23 Med24 Med20 Tasp1 Akap8l Cxxc1 Kat8 H2bc18 Med27 Med12 Kat2b Med1 H2az2 Yeats2 Rbbp5 Med13 H2bc4 Med14 Hist1h4m Wdr82 H2bc1 Med10 Rxra Ccnc Med4 Hist1h2ai Paxip1 Pparg Med6 Kat14 Phf20 Mbip Hcfc1 Med16 Tbl1x Med17 Hcfc2 Dr1 Kansl3 Kansl1 Kansl2 Phf20l1 Ajuba Bod1l1 Pagr1 Tada3 Med30 Tada2a Med31 Ppargc1a Ppargc1b Mcrs1 Zzz3 Hdac3 Sgf29 Psip1 Tbl1xr1 Ogt Kat2a Rb1 H2ab2 Ncor2 Gps2 H2ac4 Ncoa3 Sirt1 Setd1b Setd1a Abl1 ENSRNOG00000066901 COENZYME A BIOSYNTHESIS%REACTOME%R-RNO-196783.1 Coenzyme A biosynthesis Ppcs Dcakd Ppcdc Coasy Pank3 Pank2 Pank1 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 96%10222705 Amino Acid conjugation Glyatl3 Acsm2 Acsm4 Acsm5 Glyat HEDGEHOG 'ON' STATE%REACTOME%R-RNO-5632684.1 Hedgehog 'on' state Grk2 Psma4 Psma3 Psma6 Psma5 Cdc73 Psma2 Psma1 Itch Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Smurf2 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Dzip1 Psmd6 Gpr161 Psmd8 Ihh Gli1 Psmd2 Gli3 Gli2 Psmd1 Shh Adrm1 Kif7 Rbx1 Evc Smo Spop Ulk3 Smurf1 Cdon Dhh Spopl Ptch1 Evc2 Hhip Sufu Numb Cul3 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 96%10222797 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Uba52 Tbk1 Irf3 Ikbke Optn Rps27a Ptpn11 Traf3 Tank Ly96 Ticam2 Ubb Sarm1 Irf7 Ubc Ticam1 Cd14 Tlr4 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 96%10223357 Regulation of pyruvate dehydrogenase (PDH) complex Pdp1 Pdpr Pdp2 Dld Pdhx Pdha1 Pdha2 Pdk4 Pdk3 Dlat Pdk2 Pdk1 Pdhb Gstz1 HEME DEGRADATION%REACTOME DATABASE ID RELEASE 96%10222691 Heme degradation Gsta5 Slco2b1 Fabp1 Blvrb Hmox2 Blvra Abcg2 Abcc1 Hmox1 Abcc2 Ugt1a2 Ugt1a1 Ugt1a3 Ugt1a5 Alb Slco1b2 ANDROGEN BIOSYNTHESIS%REACTOME%R-RNO-193048.1 Androgen biosynthesis Hsd3b Lhb Hsd17b3 Cga Cyp17a1 Hsd3b6 Hsd3b5 Srd5a3 Hsd3b1 Srd5a1 Hsd17b12 Srd5a2 Hsd3b5-ps1 Pomc DNA REPLICATION%REACTOME DATABASE ID RELEASE 96%10221907 DNA Replication Polg2 Twnk Gins2 Gins1 Gins4 Gins3 Ssbp1 Polg Polrmt Dna2 Kpnb1 Kpna6 Lig1 Kpna1 Fen1 Rfc5 Pold2 Pold1 H2ab2 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 H2ac4 Pola1 Pold4 Pold3 Prim2 Prim1 ENSRNOG00000066901 H2ac18 Hist1h2bq H2aj Psma4 Ccna1 Psma3 H3-3b Ccna2 Ube2s Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Orc4 H2bc18 Cdc26 Orc6 Cdc23 Orc1 Skp2 Orc3 H2az2 Skp1 Orc2 Cdt1 H2bc4 Gmnn Psmb5 Hist1h4m Psmb4 H2bc1 Cdc7 Psmb7 Cdc6 Psmb6 Hist1h2ai Mcm7 Psmb1 Mcm8 Psmb3 Dbf4 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Mcm10 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Anapc5 Pole4 Anapc4 Rpa1 Anapc1 Rpa2 Anapc2 Fzr1 Ubb Rpa3 Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Pole Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdc16 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%10225089 Aryl hydrocarbon receptor signalling Ahrr Ahr Hsp90ab1 Ptges3 Arnt2 Arnt GPER1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222497 GPER1 signaling Prkar1a Shc1 Prkar2a Prkar1b Itgb1 Prkar2b Prkaca Prkacb INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 96%10225003 Interaction between PHLDA1 and AURKA Phlda1 Aurka CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 96%10224135 Cross-presentation of soluble exogenous antigens (endosomes) Psmb6 Psmb1 Psmb3 Psmb2 Psme2 Psme1 Psma7 Psmb9 Psmb10 Psmb8 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Fcgr1a Psmb6l1 Psmd7 Cd207 Mrc2 Psmd6 Mrc1 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 96%10223713 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Dpp4 Gpr119 Ffar1 Gip RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-RNO-5213460.1 RIPK1-mediated regulated necrosis Peli1 Uba52 Traf2 Birc2 Xiap Ubb Sdcbp Ogt Ubc Casp8 Mlkl Flot2 Flot1 Ripk3 Tradd Cflar Prkn Hsp90aa1 Stub1 Itch Ripk1 Rps27a Tnfsf10 Pdcd6ip Fas Cdc37 Fadd Faslg Ube2l3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 96%10222885 IKK complex recruitment mediated by RIP1 Ikbkg Ube2n Uba52 Ube2d1 Ripk3 Birc2 Ripk1 Rps27a Ube2d3 Chuk Ube2d2 Ly96 Ikbkb Ticam2 Ubb Sarm1 Ubc Ticam1 Cd14 Traf6 Tlr4 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-375276.1 Peptide ligand-binding receptors F2rl2 F2rl3 Prokr2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Oprm1 Cxcr4 Cxcr5 Oprl1 Uts2 Mc5r Prlh Pomc Tacr1 Tacr3 Tacr2 Anxa1 Cxcl11 Hebp1 Cxcl12 Cxcl10 C5ar2 F2r C5ar1 Aplnr Bdkrb2 Bdkrb1 Nts Kng1 App Tac3 Tac1 Pmch Ccrl2 Gper1 Pyy Ednrb Rln3 Ednra Rln1 Cxcl16 Cxcl13 Apln Trhr Prlhr Oxt Oprd1 Ece1 Ece2 Trh C3ar1 Npy5r Galr2 Galr3 Galr1 Avpr2 Sstr5 Sstr4 Sstr3 Kel Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Npy4r Rxfp1 Cx3cr1 Insl3 Psap Ppbp Fpr1 Nmbr Xcl1 Fpr2 Ccr10 Kiss1 Agt C3 Nln C5 Ccl9 Pnoc Cxcl9 Ccl7 Ppy Ccl6 Ccl5 Nmb Oxtr Ccl4 Ccl3 Xcr1 Ccl1 Cxcl1 Grpr Cxcl2 Cxcl3 Nms Cxcl5 Nmu Uts2b Cckar Npffr1 Npbwr1 Npffr2 Gpr37l1 Npff Ackr3 Hcrtr2 Ackr4 Nmur2 Hcrtr1 Cck Qrfprl Qrfpr Ackr2 Nmur1 Qrfp Ntsr2 Hcrt Uts2r Ntsr1 Sst Oprk1 Brs3 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 Ccr3 Edn1 Edn2 Edn3 Cckbr Agtr1 Agtr2 F2 Gpr37 Mc1r Gal Penk Avp Npb Grp Kiss1r Ccl19 Ccl17 Nps Mc4r Ccl11 Ccl12 Npw Npy Pf4 Cx3cl1 Fpr2l3 Prok2 Ccl27 Npsr1 Prok1 Pdyn Mc3r Ccl20 Ccl21 F2rl1 Fpr2l1 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 96%10224763 Phospholipase C-mediated cascade: FGFR1 Fgf17 Fgf10 Plcg1 Fgf2 Fgf1 Fgf20 Fgf4 Kl Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgfr1 Fgf9 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-RNO-975634.1 Retinoid metabolism and transport Lrp10 Plb1 Lrp12 Ttr Gpc1 Rdh11 Gpc3 Gpc2 Akr1c18 Gpc5 Akr1c12l1 Gpc4 Akr1c19 Bco2 Bco1 Gpc6 Clps Akr1c21 Pnlip Akr1b10 Rbp4 Apom Rbp2 Rbp1 Sdc1 Lrat Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Akr1c9 Agrn Apoc2 Apoa1 Apoc3 Apoa2 Apoe Apoa4 Apob Lrp1 Sdc4 Sdc3 Sdc2 Lpl Gpihbp1 Lrp8 Lrp2 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-RNO-3928665.1 EPH-ephrin mediated repulsion of cells Mmp2 Ephb1 Aph1b Ephb2 Ephb3 Ephb4 Tiam1 Ephb6 Mmp9 Rac1 Lyn Yes1 Src Vav3 Fyn Vav2 Psenen Psen1 Psen2 Efnb1 Ncstn Aph1a Efnb2 Efnb3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 96%10224413 MASTL Facilitates Mitotic Progression Mastl Arpp19 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 96%10224333 Synthesis of IPs in the ER lumen Minpp1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-RNO-918233.1 TRAF3-dependent IRF activation pathway Irf3 Irf7 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-110381.1 Resolution of AP sites via the single-nucleotide replacement pathway Polb Apex1 Xrcc1 Lig3 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 96%10225445 Cellular response to mitochondrial stress Oma1 Eif2s3 Eif2ak1 Yme1l1 Dele1 Eif2s2 Stoml2 Eif2s1 Phb2 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%10224695 DAG1 glycosylations Pomgnt2 Pomt1 Pomt2 Chst10 Fkrp Slc35a4 Rxylt1 Crppa Dag1 Large1 Large2 Fktn Pomgnt1 Slc35a1 Mgat5b B4gat1 B3galnt2 Pomk LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223677 Leukotriene receptors Cysltr2 Cysltr1 Ltb4r Gpr17 Ltb4r2 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 96%10224285 Cysteine formation from homocysteine Cbs Cth INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10223493 Integrin signaling Apbb1ip Fgb Fga Fgg Pdpk1 Itga2b Syk Rasgrp1 Csk Tln1 Fn1 Itgb3 Bcar1 Shc1 Ptpn1 Rapgef4 Rapgef3 Rasgrp2 Ptk2 Akt1 Src Grb2 Rap1a Rap1b Sos1 Crk BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224989 Butyrophilin (BTN) family interactions Btn1a1 Btnl9 Btn2a2 Cd209a Btnl2 Ppl Xdh REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%10225397 Regulation of CDH1 Expression and Function Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Src Fyn Ctbp1 Ctsb Cbll1 Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Mogs Vcl Hdac2 H2ab2 Twist1 Kmt5a H2ac4 Sec11c Sec11a Prkcsh Sirt1 Zmym2 ENSRNOG00000066901 Pomt1 Dnttip1 Pomt2 Furin Pcsk7 Pcsk6 H2ac18 Ctbp2 Csnk2a2 Ctsl Zeb1 Csnk2a1 Hist1h2bq Hdac1 Ganab Csnk2b Mphosph8 H2aj Canx Arhgap32 Spcs3 Spcs1 Spcs2 Psma4 Smarca4 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Ezh2 Dad1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 96%10223543 Degradation of the extracellular matrix Adamts4 Mmp16 Mmp17 Mmp19 Adam8 Mmp8 Try10 Furin Acan Prss2l1 Ctrb1 Mmp10 Cast Col15a1 Capn15 Col13a1 Plg Klkb1 Col19a1 Phykpl Spp1 Ctsk Try5 Ctsl Cd44 LOC102554637 Capn9 Scube3 Capn8 Scube1 Capn5 Capn7 Capn6 Col25a1 Capn1 Timp1 Capn3 Capn2 Timp2 Prss2 Prss3 Tmprss6 Elane Mmp1b Tpsb2 Prss1 Spock3 Capns1 Capn10 A2m Capn11 Capn12 Capn13 Ctsb Ctss Cdh1 Mmp7 Mmp2 Bcan Mmp3 Mmp9 Dcn Mmp24 Mmp25 Col18a1 Adam15 Ctsd Optc Adam10 Bsg Ctsg Htra1 ENSRNOG00000069479 Mmp20 Mmp11 Col26a1 Mmp12 Mmp13 Mmp14 Cma1 Adamts5 Mmp15 EUKARYOTIC TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 96%10222665 Eukaryotic Translation Elongation Eef1d Eef1b2 Eef1g Eef1a1 Eef2 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-RNO-881907.1 Gastrin-CREB signalling pathway via PKC and MAPK Creb1 Mmp3 Egfr Mapk3 Hbegf Rps6ka3 Nras Prkca Mapk1 Grb2 Rps6ka1 Kras Gast Sos1 Rps6ka2 Hras Cckbr Mapk7 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-RNO-72662.1 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Rps14 Rps15 Rps16 Eif2s3 Rps17 Rps15a Rps18 Eif2s2 Rps19 Rps2 Pabpc1 Eif2s1 Rps27 Rpsa Rps10 Rps11 Rps13 Rps4x-ps13 Rps3a Rps27l Rps9 Rps7 Uba52 Rps8 Rps5 Eif4h Rps26-ps13 Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Rps3 Rps25 Rps4x Rps26 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Eif1ax Eif4a2 Eif4a1 Fau Eif4ebp1 Rps6 Eif4e DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 96%10223969 Deubiquitination Tnks2 Rce1 ENSRNOG00000067432 Axin1 Axin2 Ide Prkn Rnf146 Ripk1 Tnks Usp34 Usp9x Smurf2 Traf6 Ikbkg Map3k7 Apc Traf2 Tnip2 Nod2 Nod1 Ripk2 Kat2a Nlrp3 Rig1 Nfkbia Cyld Usp14 Usp18 Tab1 Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Cdc25a Psmd13 Skp2 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Ube2d1 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Stambpl1 Psmd8 Nfrkb Myc Psmd2 Foxk2 Foxk1 Psmd1 Vdac2 Adrm1 Yod1 Vdac3 Vdac1 Tfpt Cdk1 Becn1 Tomm70 Otud7a Actr5 Otud7b Yy1 Actr8 Josd2 Josd1 Rnf123 Rnf128 Stam Snx3 Ar Hif1a Zranb1 Cftr Siah2 Keap1 Ino80 Wdr48 Ddb2 Ufd1 Foxo4 Uchl3 Abraxas2 Uchl5 Ifih1 Fkbp8 Ino80e Ino80d Ino80c Ino80b Il33 Wdr20 Mbd5 Mbd6 Adrb2 Uchl1 Nedd8 Atxn3 Atxn7 Suds3 Usp2 Mul1 Usp3 Usp4 Kdm1b Usp5 Usp7 Usp8 Hgs Ruvbl1 Stambp Rad23a Rad23b Tomm20 Tada2b Smad1 Smad2 Smad3 Smad4 Smad7 Otub1 Usp44 Rhoa Usp42 Usp48 Usp47 Stam2 Usp30 Otub2 Vcpip1 Usp33 Usp37 H2ac25 Mysm1 Tnip3 Tnip1 Senp8 Otud3 Usp22 Usp21 Usp20 Usp26 Usp25 Usp24 Usp29 Usp28 Ccp110 Asxl1 Arrb2 Asxl2 Arrb1 Pten Usp12 Tgfbr1 Usp11 Usp10 Usp16 Usp15 Usp13 Usp19 Bard1 Tp53 Clspn Polb H2ac4 Bap1 Actl6a Gata3 Brcc3 ABRAXAS1 Esr1 Birc2 H2ac18 Babam1 Babam2 Brca1 Uimc1 Actg1 Taf9b Taf10 Ep300 ENSRNOG00000068602 Kat2b Hist1h2ai Hcfc1 Tada3 Mcrs1 Ogt Vcp Mdm4 Traf3 Mat2b MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10222381 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Acadm Decr1 Eci1 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190373.1 FGFR1c ligand binding and activation Fgf17 Tgfbr3 Gipc1 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf5 Fgf8 Fgfr1 Fgf9 SPHINGOLIPID CATABOLISM%REACTOME%R-RNO-9845614.1 Sphingolipid catabolism Acer1 Acer2 Aldh3b1 Sgpl1 Aldh3b2 Acer3 Sgpp2 Plpp2 Aldh3a2 Plpp3 Plpp1 Sgpp1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-RNO-5654687.1 Downstream signaling of activated FGFR1 Frs2 Plcg1 Frs3 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Flrt1 Flrt3 Fgf9 Fgfr1 Flrt2 Fgf17 Pik3ca Shc1 Fgf10 Pik3r1 Nras Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Kl Fgf23 Fgf22 Gab1 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10223783 Negative epigenetic regulation of rRNA expression Suv39h1 Rrp8 Hist1h2ai H2aj H2ab2 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Mbd2 Sirt1 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m H2bc1 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-181430.1 Norepinephrine Neurotransmitter Release Cycle Rims1 Maoa Tspoap1 Syt1 Stx1a Ppfia3 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Unc13b Snap25 Slc18a2 Cplx1 Slc22a2 Slc22a1 Vamp2 Rab3a TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 96%10222829 Toll Like Receptor TLR1:TLR2 Cascade Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Tirap Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-RNO-5620920.1 Cargo trafficking to the periciliary membrane Exoc3 Exoc4 Exoc5 Exoc6 Exoc1 Exoc2 Exoc7 Exoc8 Tcp1 Inpp5e Arl6 Arl3 Cnga4 Cnga2 Bbip1 Cct8 Cct5 Cct4 Bbs2 Atat1 Rab8a Pde6d Ttc8 Nphp3 Lztfl1 Arf4 Mchr1 Rab11a Gbf1 Rho Sstr3 Smo Mkks Unc119b Arl13b Pkd1 Rp2 Asap1 Bbs9 Bbs7 Bbs5 Bbs4 Cct3 Cct2 Bbs10 Bbs12 Thoc2l Cngb1 Rab3ip INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%10223909 Interleukin-2 family signaling Stat3 Stat1 Syk Il15 Il15ra Lck Il9 Il21 Ptk2b Stat5a Stat5b Il9r Inpp5d Jak2 Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Grb2 Pik3r2 Pik3r3 Inppl1 Pik3cd Sos1 Sos2 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-RNO-196819.1 Vitamin B1 (thiamin) metabolism Thtpa Tpk1 Slc19a2 Slc19a3 Slc25a19 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-RNO-9018519.1 Estrogen-dependent gene expression Cbfb Esr1 Crebbp H2ac18 Tle3 Hist1h2bq Prmt1 Hdac1 H2aj Tbp H3-3b Hist3h2ba Gtf2a1 Ep300 Nrip1 Gtf2a2 Hsp90aa1 ENSRNOG00000068602 Polr2c Polr2a Polr2b H2bc18 Polr2g Runx1 Atf2 Polr2h Kat2b H2az2 Polr2e Polr2f H2bc4 Kdm1a Hist1h4m Polr2i H2bc1 Polr2j Hist1h2ai Pgr Kat5 Gtf2f2 Gtf2f1 Fos Greb1 Cited1 Cdk9 Pou2f1 Fkbp4 Hsp90ab1 H2ab2 Ptges3 Jun Carm1 H2ac4 Zfp217 Foxa1 Ncoa3 Kdm4b Gata3 Yy1 Nr5a2 ENSRNOG00000066901 GASTRULATION%REACTOME DATABASE ID RELEASE 96%10225431 Gastrulation Tfap2c Tfap2a Tfap2b ALPK1 SIGNALING PATHWAY%REACTOME%R-RNO-9645460.1 ALPK1 signaling pathway Rps27a Tab3 Tab2 Map3k7 Tifa Uba52 Tab1 Ubb Ubc Alpk1 Traf6 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-RNO-909733.1 Interferon alpha beta signaling Uba52 Stat1 Ubb Kpnb1 Ubc Kpna1 Ptpn1 Ptpn6 Ifnar1 LOC120103158 LOC120103159 Ifnar2 Ifnb1 Rnasel Ifna4 Socs3 Ifna1 Ifna1l1 Ifna4l1 Rps27a Irf9 Usp18 Tyk2 Ptpn11 Socs1 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-RNO-110357.1 Displacement of DNA glycosylase by APEX1 Mbd4 Mpg Smug1 Ogg1 Nthl1 Tdg Apex1 Mutyh Ung ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-RNO-418990.1 Adherens junctions interactions Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Xiap Src Fyn Ctbp1 Tyk2 Il6st Nfkb1 Ctsb Cbll1 Rela Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Mogs Nectin1 Angptl4 Cdh9 Nectin2 Pvr Cdh8 Vcl Hdac2 Jak2 Nectin4 Cdh7 Cdh6 H2ab2 Cdh3 Cdh2 Twist1 Il6 Kmt5a H2ac4 Sec11c Amot Sec11a Il6r Prkcsh Sirt1 Zmym2 Cadm3 Sp1 ENSRNOG00000066901 Cdh24 Cadm2 Cadm1 Rnf19b Pomt1 Hace1 Dnttip1 Pomt2 Stat3 Furin Pcsk7 Pcsk6 Birc2 H2ac18 Adam19 Afdn Ctbp2 Csnk2a2 Ang2 Ctsl Zeb1 Csnk2a1 Zeb2 Cdh18 Cdh17 Cdh15 Hist1h2bq Cdh13 Cdh12 Hdac1 Cdh11 Cdh10 Ganab Csnk2b Mphosph8 H2aj Canx Tiam1 Arhgap32 Spcs3 Rac1 Spcs1 Spcs2 Psma4 Smarca4 Farp2 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Vav2 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Arhgef4 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Cdc42 Ezh2 Dad1 HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 96%10224241 Hydrolysis of LPC Pla2g4e Pla2g4a Pla2g4d Plbd1 Pla2g15 Pla2g4b Pla2g4f Pla2g4c RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-RNO-8868773.1 rRNA processing in the nucleus and cytosol LOC120093247 Heatr1 Nob1 Utp11 Ddx52 Rpl36a Utp18 Wdr43 Rrp7a Noc4l Dis3 Rplp2 Tex10 Riok1 Riok2 AABR07072440.1 Gnl3 Rpl35al8 Ddx49 Wdr36 Rpl22l1 Rplp0 Ddx47 Rplp1 Rpl13a Rpl35al2 Rpl18a Nip7 Rpl13 Rpl14 Rrp36 Rpl15 Mphosph6 Nol9 Rpl17 Rpp14 Rpl18 Rpl19 Nol6 Utp14a Mphosph10 Rpl10 Pes1 Rpl11 Bms1 C1d Rpl12 Rpl10a Exosc9 Exosc8 Exosc5 Krr1 Exosc4 Exosc7 Exosc6 Exosc1 Utp3 Exosc3 Utp4 Rps2 Exosc2 Utp6 Nop58 Nop56 Bop1 LOC134480579 Ebna1bp2 Csnk1d Wdr18 Tsr1 Ddx21 Rpl23a Wdr12 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Las1l Rps27 Ltv1 Rpsa Rpl35 Rps10 Fcf1 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rrp9 Rps8 Rpl6 Rps5 Pwp2 Rpl7 Rps26-ps13 Rpp38 Bysl Fbl Rpl30 LOC134486107 Rpl31 Rpl32 Rpp30 Rpl34 Rpl36al1 Ftsj3 Rpl39l1 Rpl24 Rpl26 Rps3 Imp4 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rpp25 Rps29 Rpl12-ps1 Ubc Rps20 Ncl Rps21 Rpl22 Rps23 Xrn2 Rps24 Rpl23 Snu13 Wdr75 Senp3 Fau Isg20l2 Exosc10 Emg1 Eri1 LOC120097744 Dhx37 Rpl36l5 Rpl36l3 Rpl3l Pdcd11 Pno1 Rpl27a Rpl31l15 Utp20 Nop14 Pelp1 Rcl1 Utp25 Tbl3 Nol11 Rps6 Rpp40 LOC100910714 LOC102551819 Wdr3 Bud23 Dcaf13 Csnk1e Utp15 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-RNO-3000471.1 Scavenging by Class B Receptors Prdx1 Apob Scarb1 Cd36 S100a9 Hmgb1-ps34 Apoa1 Hmgb1l2 Hmgb1l1 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-RNO-76046.1 RNA Polymerase III Transcription Initiation Snapc3 Snapc4 Snapc1 Snapc2 Polr3gl Gtf3a Crcp Polr3a Brf2 Polr3d Brf1 Polr1c Polr3e Polr3b Polr3c Polr3f Polr3g Pou2f1 Gtf3c2 Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 Gtf3c5 Bdp1 Tbp Polr2h Polr2e Polr2f NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME DATABASE ID RELEASE 96%10222485 Neurotransmitter receptors and postsynaptic signal transmission Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Gnai2 Gnai1 Prkca Gnai3 Camk4 Prkar1a Prkar1b Calm3 Nsf Gng3 Gnal Gng5 Gng4 Gng7 Creb1 Gng8 Gngt1 Kcnj9 Gnat3 Kcnj6 Prkar2a Kcnj5 Prkar2b Kcnj4 Cacng4 Kcnj3 Kcnj10 Cacng2 Kcnj2 Gnb2 Gnb1 Gnb4 Kcnj12 Grin2a Gnb3 Gnb5 Lrrc7 Kcnj15 Gria4 Gng11 Kcnj16 Gria3 Camk2g Camk2d Gria2 Camk2b Dlg1 Dlg2 Gria1 Actn2 Dlg3 Dlg4 Camk2a Nefl Grin1 Grik2 Grin2d Grik1 Grin2c Grin2b Rps6ka3 Rps6ka1 Rps6ka2 Cacng8 Cacng3 Chrnb4 Chrnb3 Chrnb2 Grip2 Prkcb Epb41l1 Gabrg2 Gabrg3 Grin3a Chrna3 Chrna2 Chrna1 Ap2s1 Chrna7 Grik5 Chrna6 Chrna5 Chrna4 Ap2a2 Grik4 Ap2a1 Chrna9 Grik3 Ap2b1 Pick1 Gabra4 Gabra3 Gabra6 Gabra5 Gabra2 Gabra1 Akap5 Glra3 Glra2 Glra1 Rps6ka6 Tspan7 Camk1 Glrb Ncald Grip1 Chrnd Gabrr1 Chrne Gabrr3 Gabrr2 Chrng Gabrq Gabrb1 Gabrb3 Gabrb2 Htr3b Htr3a Gabbr1 Gabbr2 Arhgef9 Ap2m1 Myo6 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 ESR-MEDIATED SIGNALING%REACTOME%R-RNO-8939211.1 ESR-mediated signaling Ereg Pdpk1 Btc Gnai2 Gnai1 Gnai3 Tle3 Calm3 S1pr3 Creb1 Gnat3 Ptk2 Mapk3 Hbegf Src Nras Kras Polr2c Hras Polr2a Tgfa Polr2b Polr2g Atf2 Polr2h Areg Polr2e Polr2f Polr2i Polr2j Kat5 Gtf2f2 Gtf2f1 Fos Egfr Hsp90ab1 H2ab2 Jun H2ac4 Kdm4b Gata3 ENSRNOG00000066901 Ppp5c Cbfb Esr1 Crebbp H2ac18 Egf Hist1h2bq Prmt1 Hdac1 Pik3ca H2aj Shc1 Cav1 Akt3 Tbp H3-3b Akt2 Akt1 Hist3h2ba Gtf2a1 Pik3r1 Ep300 Nrip1 Gtf2a2 Hsp90aa1 ENSRNOG00000068602 Pik3r2 Pik3r3 Ppid Uhmk1 H2bc18 Ppidl1 Runx1 Kat2b H2az2 H2bc4 Kdm1a Hist1h4m H2bc1 Sphk1 Hist1h2ai Zdhhc7 Pgr Xpo1 Greb1 Cited1 Strn Prkcz Cav2 Esr2 Cdk9 Igf1r Pou2f1 Foxo3 Mmp7 Mmp2 Mmp3 Cdkn1b Zdhhc21 Fkbp4 Mmp9 Fkbp5 Ptges3 Carm1 Zfp217 Foxa1 Ncoa3 Mapk1 Nos3 Yy1 Nr5a2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%10222221 Signaling by Insulin receptor Ins2 Pdpk1 Frs2 Atp6v0b Trib3 Atp6v0a4 Grb10 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Fgfr3 Atp6v1c1 Fgfr4 Atp6v0c Fgfr1 Ptprf Fgfr2 Fgf16 Them4 Pde3b Tlr9 Fgf17 Atp6ap1 Pik3ca Fgf18 Shc1 Insr Atp6v1e2 Fgf19 Atp6v1e1 Tcirg1 Gab2 Atp6v1a Atp6v1b2 Fgf10 Atp6v0d2 Ide Mapk3 Akt2 Atp6v0d1 Atp6v1b1 Pik3r1 Atp6v0e1 Pik3cb Atp6v1g2 Atp6v1g1 Atp6v1f Pik3r2 Grb2 Atp6v1d Sos1 Ptpn11 Fgf20 Fgf23 Fgf22 Pik3c3 Gab1 Irs2 Pik3r4 Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Ptpn1 Mapk1 Ctsd Kl Flt3 Ins1 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-RNO-917977.1 Transferrin endocytosis and recycling Atp6v0b Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Atp6ap1 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Hfe Tf Steap3 Steap4 Mcoln1 Tfrc Tfr2 CARGO CONCENTRATION IN THE ER%REACTOME DATABASE ID RELEASE 96%10224861 Cargo concentration in the ER Lman1 Lman2 Serpina1 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Preb Tmed2 Folr1 Cd59 Sec23a Lman2l Cnih1 Cnih3 Cnih2 Ctsc Mia2 Mia3 Sar1b Tmed10 Col7a1 Tgfa Areg Gria1 F8 Ctsz Gosr2 Lman1l LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223825 Lysosome Vesicle Biogenesis Ap1m2 Vamp7 Bloc1s1 Ap1m1 Vamp8 Ap4s1 Ap1s3 Arrb1 Ap1s2 Txndc5 Ap1g2 Ap1g1 Ap4m1 Hspa8 Ap4e1 M6pr Dnm2 Clta Cltb Hgs Cltc Arf1 Gns Vamp2 App Dnajc6 Sh3gl2 Clvs1 Dnase2 Clvs2 Ctsz Ap4b1 Ap1b1 Chmp2a APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 96%10224747 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Neil1 Polb Ogg1 Xrcc1 Neil2 Lig3 Pnkp CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223775 Cation-coupled Chloride cotransporters Slc12a1 Slc12a4 Slc12a5 Slc12a2 Slc12a3 Slc12a6 Slc12a7 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223791 Type II Na+ Pi cotransporters Slc34a1 Slc34a3 Slc34a2 HS-GAG BIOSYNTHESIS%REACTOME%R-RNO-2022928.1 HS-GAG biosynthesis Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Gpc6 Sdc1 Hs3st4 Hs3st1 Hs3st2 Extl2 Hs3st5 Hs3st6 Hs3st3b1 Hs2st1 Ndst1 Ndst2 Ndst3 Ndst4 Agrn Hs3st3a1 Hs6st3 Hs6st2 Hs6st1 Ext2 Ext1 Slc35d2 Sdc4 Sdc3 Sdc2 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224411 Ubiquinol biosynthesis Pdss2 Coq8a Pdss1 Coq8b Coq2 Coq3 Coq4 Coq5 Coq6 Hpdl Coq7 Coq9 Stard7 CHOLESTEROL BIOSYNTHESIS%REACTOME%R-RNO-191273.1 Cholesterol biosynthesis Hmgcr Mvd Msmo1 Srebf1 Fdps Plpp6 Idi1 Hsd17b7 Mvk Fdft1 Sqle Ebp Hmgcs1 Arv1 Ggps1 Sc5d Lbr Acat2 Nsdhl Dhcr24 Dhcr7 Lss Tm7sf2 Srebf2 Pmvk RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10224733 RHO GTPases regulate CFTR trafficking Gopc Rhoq Cftr NGF PROCESSING%REACTOME%R-RNO-167060.1 NGF processing Furin Pcsk5 Ngf Pcsk6 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-RNO-983169.1 Class I MHC mediated antigen processing & presentation Mib2 Ube2d3 Ube2d2 Cd207 Mrc2 Mrc1 Prkn Stub1 Sar1b Ube2l3 Kbtbd7 Smurf2 Ube2n Cd36 Fbxw11 Cbll1 Ube2j2 Itgav Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Vamp8 Psmb2 Uba52 Anapc10 Ube2d1 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Cdc16 Rnf123 Siah2 Keap1 Lrr1 Nedd4 Rnf220 Fbxl21 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb RT1-M6-2 Vamp3 Sh3rf1 Trim11 Ube2l6 Mex3c Cdc34 B2m Dcaf1 Rnf126 Ubac1 Lnpep Sec23a Atg7 Rnf114 Rnf115 Rnf111 RT1-M10-ps1 RT1-M10-ps5 Snap23 Siah1 Dzip3 Mkrn1 Ube2g2 Ube2g1 Rnf138 RT1-N3 Rnf130 Kbtbd8 Fbxw4 Fbxw5 Fbxw7 Gan Fbxw8 Fbxw9 Anapc13 Det1 Fbxw2 Klhl5 Rbck1 Arih2 Rlim Klhl3 Sec31a Klhl2 Ube4a Spsb2 RT1-M1-2 Trim9 Spsb1 Trip12 Wwp1 RT1-M1-5 Spsb4 Calr Rt1-ec3 Lrsam1 Eloc Huwe1 Elob Ube2j1 Sec24d Kctd7 Sec24c Ube2u Sec24b Kctd6 Sec24a Ncf1 Ncf2 Ube2w Ncf4 Ube2m Ube2k Rnf182 Ube2o Ltn1 Pdia3 Ube2v2 Ube2b Mgrn1 Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Tap2 Tap1 Fbxo17 Lmo7 Rnf41 Mylip Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Fbxo21 RT1-M5 Fbxo22 Ubox5 Ubr1 Rnf19a Ubr2 Glmn Ubr4 RT1-M2 Fbxo27 Uba5 Uba6 Trim69 Uba7 Fbxw17 Herc2 Socs1 Trim71 Klhl25 Rnf19b Ube2e3 Ube2e2 Klhl21 Btbd6 Hace1 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Psme2 Fbxl7 Psme1 Lonrf1 Psmb9 Zbtb16 Psmb10 Hspa5 Psmb8 Uba1 Cyba Cybb Uba3 Cul2 Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Canx Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Pja2 Pja1 Arel1 Trim63 Rnf144b Fbxo2 Asb12 Asb14 Itch Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Herc6 Fbxo9 Trim21 Vhl Tapbp Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Trim36 Trim32 Trim41 Unkl Erap1 Asb9 Asb7 Asb6 Asb5 Rnf25 Asb4 AABR07044308.1 Rchy1 Asb1 Lnx1 Fcgr1a Sec13 Rbx1 Socs3 Smurf1 Cul3 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 96%10222811 Creation of C4 and C2 activators Fcn2 Fcn1 Mbl2 Masp1 Masp2 C1qb Crp C1qa Colec10 C1s C1r C1qc ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 96%10222927 p38MAPK events Ralgds Kras Mapkapk3 Hras Mapk14 Mapkapk2 Mapk11 Nras ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 96%10224233 Acyl chain remodelling of PG Pla2g4f Pla2g2d Pla2g2f Pla2g2a Pla2g1b Pla2g4a Pla2g4d Pla2r1 Pla2g12a Pla2g4b Lpcat4 Pla2g10 Lpgat1 Lpcat1 Pla2g5 Pla2g3 Crls1 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 96%10222057 Neurotransmitter uptake and metabolism In glial cells Glul Slc38a1 Slc1a3 Slc1a2 RHOT2 GTPASE CYCLE%REACTOME%R-RNO-9013419.1 RHOT2 GTPase cycle Rhot2 Mfn1 Mfn2 Trak1 Myo19 Trak2 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%10224697 DAG1 core M3 glycosylations Pomgnt2 Pomt1 Pomt2 Dag1 B3galnt2 Pomk GLUCOSE METABOLISM%REACTOME%R-RNO-70326.1 Glucose metabolism Aldoa Nup133 Pfkl Nup210 Nup155 Pgk2 Nup153 Pck1 Pfkm Pfkp Pck2 Pgm2l1 G6pc1 Pkml1 Gck Hk2 Hk3 Adpgk G6pc3 Tpi1l2 Aldob Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Gnpda1 Gpi Nup205 Gnpda2 Nup107 Eno3 Sec13 Eno2 Eno4 Nup188 Pfkfb4 Tpr Pfkfb3 Pfkfb2 Nup160 Pgk1 Pfkfb1 Rae1 Pc Pgam2 Ndc1 Pgam1 Slc37a4 Tpi1 Nup85 Slc37a2 Nup42 Slc37a1 Nup62 Hkdc1 Nup43 Nup88 Fbp1 Fbp2 Gckr Aaas Pklr Ranbp2 Gapdhs Aldoc Nup214 Bpgm LANOSTEROL BIOSYNTHESIS%REACTOME%R-RNO-9969896.1 Lanosterol biosynthesis Hmgcr Mvd Fdps Plpp6 Idi1 Mvk Fdft1 Sqle Hmgcs1 Ggps1 Acat2 Lss Pmvk ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 96%10224485 Activation of NIMA Kinases NEK9, NEK6, NEK7 Nek9 Ccnb1 Plk1 Ccnb2-ps2 Ccnb2 Cdk1 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 96%10225447 Mitochondrial unfolded protein response (UPRmt) Hsf1 Dnaja1 Hspa1b Sirt3 Hspa1a Esr1 Akt1 Foxo3 SIGNALING BY HEDGEHOG%REACTOME%R-RNO-5358351.1 Signaling by Hedgehog Adcy5 Adcy6 Gsk3b Adcy9 Os9 Prkaca Prkacb Sel1l Prkar1a Prkar1b Rpgrip1l Tulp3 Adcy10 Ift140 Grk2 Disp2 Scube2 Kif3a Fuz Hhat Mks1 Ift52 Ttc21b Ift57 Ift122 Ofd1 Intu Prkar2a Wdr35 Prkar2b Dync2h1 Ift172 Wdr19 Notum Syvn1 Cdc73 P4hb Smurf2 Gpc5 Numb Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Itch Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Dzip1 Psmd6 Gpr161 Psmd8 Ihh Gli1 Psmd2 Gli3 Derl2 Gli2 Psmd1 Shh Adrm1 Rbx1 Cul1 Kif7 Evc Smo Spop Ulk3 Vcp Smurf1 Cdon Dhh Spopl Ptch1 Evc2 Hhip Sufu Adcy3 Adcy4 Adcy1 Cul3 Adcy2 Erlec1 Adcy7 Adcy8 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 96%10224001 Regulation of signaling by CBL Pik3ca Syk Lyn Yes1 Crkl Rapgef1 Pik3r1 Pik3cb Cbl Hck Grb2 Pik3r2 Fyn Pik3r3 Vav1 Pik3cd Crk NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME%R-RNO-9034013.1 NTF3 activates NTRK3 signaling Ntrk3 Ntf3 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-RNO-75067.1 Processing of Capped Intronless Pre-mRNA Cpsf7 Cpsf1 Ncbp2 Cpsf2 Ncbp1 Cpsf3 Snrpepl2 Snrpf Slbp Snrpg Snrpb Pcf11 Fip1l1 Cstf1 Zfp473 Papola Nudt21 Cstf2 Cstf3 Cstf2t Lsm10 Lsm11 Sympk Pabpn1 Snrpd3 Clp1 Cpsf4 Cpsf6 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 96%10224669 Regulation of TLR by endogenous ligand Fgb Fga S100a1 Fgg Gsdme Tlr1 Gsdmd Tlr7 Cd36 Tlr6 S100a9 Lbp S100a8 Tlr2 Hmgb1l2 Hmgb1l1 Apob Ly96 Hmgb1-ps34 Cd14 Tlr4 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 96%10223029 Downstream signaling of activated FGFR2 Frs2 Plcg1 Frs3 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Fgfr2 Fgf16 Fgf17 Pik3ca Shc1 Fgf18 Fgf10 Pik3r1 Nras Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Fgf22 Gab1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-RNO-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Pold2 Pold1 Rpa1 Rpa2 Rpa3 Pold4 Lig1 Pold3 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 96%10222629 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Pafah1b1 Zw10 Knl1 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Ppp2r5b Dync1h1 Ppp2r5a Spc24 Spc25 Xpo1 Nuf2 Mad2l1 Cdca8 Incenp Dync1i2 Bub1b Ndel1 Ppp1cc Dync1i1 Cenpc Cenpa Aurkb B9d2 Ppp2r5e Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ranbp2 Ckap5 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225131 RHOA GTPase cycle Lman1 Scfd1 Hmox2 Vamp3 Snap23 Acbd5 Flot2 Flot1 Rhoa Ngef Abcd3 Srgap1 Arhgap45 Stx5 Slk Ykt6 Cavin1 Daam1 Pgrmc2 Tex2 Bcr Arhgap6 Jup Arhgap5 Arhgap4 Sowahc Arhgap1 Stom Arap1 Arap3 Arap2 Arhgap9 Arhgap8 Mcam Pld1 Ccdc115 Rtkn Rhpn1 Rhpn2 Stk10 Stard8 Maco1 Ddrgk1 Faf2 Arhgdib Gmip Anln Arhgap10 Iqgap3 Diaph3 Diaph1 Arhgap19 Rasgrf2 Arhgap18 Depdc1b Cit Fam13a Arhgef28 C1qbp Arhgap22 Arhgap21 Arhgap20 Arhgap26 Arhgap24 Arhgap23 Arhgap29 Arhgap28 Ophn1 Stbd1 Dock2 Def6 Vapb Pcdh7 Myo9b Emc3 Arhgap11a Myo9a Arhgap31 Arhgap30 Prex2 Actc1 Arhgap35 Fmnl3 Tagap Racgap1 Plekhg6 Tmem87a Plekhg3 Bcap31 Ktn1 Farp1 Dlc1 Stard13 Arhgap40 Pkn2 Arhgef7 Rock2 Rock1 Pkn1 Arhgap44 Arhgap42 Tjp2 Atp6ap1 Tiam1 Arhgap32 Mcf2l Cav1 Arhgef15 Arhgef17 Arhgef11 Pik3r1 Arhgef10 Arhgef12 Arhgef19 Vav3 Pik3r2 Akap13 Vav1 Vav2 Tfrc Arhgef25 Kalrn Arhgef5 Arhgef4 Arhgef2 Arhgef1 Obscn Abr Ect2 Prex1 Trio Plekhg5 Net1 Arhgef10l Lbr Aaas Mcf2 Arhgdia PREGNENOLONE BIOSYNTHESIS%REACTOME%R-RNO-196108.1 Pregnenolone biosynthesis Stard4 Tspoap1 Star Stard6 Cyp11a1 Tspo Fdx2 Fdxr Fdx1 Akr1b1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%10222167 RNA Polymerase I Promoter Clearance Cdk7 Rbbp4 Rbbp7 H2ac18 Mnat1 Hist1h2bq Hdac1 H2aj Tbp Polr1b H3-3b Mapk3 Polr1a Polr1f Hist3h2ba Polr1g Polr1e Polr1h ENSRNOG00000068602 Chd3 Chd4 Taf1d Rrn3 Mbd2 Taf1a Taf1c Taf1b Mta1 H2bc18 Mta2 Polr2h Mta3 Mbd3 H2az2 Polr2e Cbx3 Polr2f H2bc4 Ercc6 Hist1h4m Ubtf H2bc1 Gatad2a Gatad2b Hist1h2ai Gtf2h2 Gtf2h1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Ttf1 Polr1c Hdac2 H2ab2 Ccnh H2ac4 ENSRNOG00000066901 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-RNO-1169410.1 Antiviral mechanism by IFN-stimulated genes Ppp2cb Ppp2ca Stat3 Furin Stat1 Nedd4 Plcg1 Hspa1b Ube2l6 Hspa1a Actg1 Ppp2r1b Ppp2r1a Mapk3 Rnasel Ikbkb Sfn Dnajc3 Eif2ak2 Ikbkg Sphk1 Ppp2r5a Fancl Fancm Ube2n Pim1 Fanca Fancb Fancc Mapt Fance Fancf Fancg Nck1 Hspa8 Gbp5 Pde12 Prkra Ilf2 Actb Dus2 Ilf3 Flnb Tarbp2 Snca Dhx9 Ppm1b Mx2 Arih1 Pggt1b Trim25 Ptpn2 Map2k6 Hspa1l Gbp2 Tp53 Gbp1 Ube2e1 Gbp3 Faap100 Npm1 Casp1 Oasl Hspa2 Faap24 Isg15 Faap20 Irf3 Mavs Rig1 Cdk1 Becn1 Adar Fnta Usp18 Fntb Chuk Uba7 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 96%10224985 Synaptic adhesion-like molecules Grin1 Grin2d Grin2c Grin2b Lrfn2 Rtn3 Flot2 Lrfn3 Flot1 Lrfn4 Lrfn1 Ptprs Grin2a Gria4 Gria3 Dlg1 Gria1 Dlg3 Dlg4 Ptprf APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-RNO-174178.1 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Aurka Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-RNO-156827.1 L13a-mediated translational silencing of Ceruloplasmin expression LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Rps14 Rps15 Rps16 Eif2s3 Rps17 Rpl4 Rps15a Rpl5 Rps18 Eif2s2 Rpl3 Rps19 Rps27 Pabpc1 Eif2s1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Eif4h Rpl7 Rps26-ps13 Eif3m Eif3j Eif3i Rpl30 Eif3l LOC134486107 Eif3k Rpl31 Eif3f Rpl32 Eif3e Eif3h Rpl34 Eif3g Rpl36al1 Eif3b Eif3a Rpl39l1 Eif3d Rpl24 Eif3c Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Eif1ax Eif4a2 Eif4a1 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 Eif4e OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME%R-RNO-1234176.1 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Cul2 Ube2d3 Ube2d2 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Vhl Psmb1 Psmb3 Psmb2 Uba52 Eloc Ube2d1 Elob Psma7 Ajuba Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Egln1 Egln2 Egln3 Epas1 Hif3a Wtip Limd1 Hif1a PURINE CATABOLISM%REACTOME%R-RNO-74259.1 Purine catabolism Itpa Pnp Dnph1 Nudt5 Xdh Nudt9 Nudt16 Gda Nudt18 Adprm Nt5c Nt5c1a Nt5c1b Nt5e Nudt1 Nt5c2 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224205 GRB7 events in ERBB2 signaling Grb7 Erbb2 Erbb3 Nrg2 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224361 DS-GAG biosynthesis Bcan Vcan Dsel Ust Dse Ncan Cspg5 Bgn Dcn Cspg4 Chst14 Chst15 CS DS DEGRADATION%REACTOME%R-RNO-2024101.1 CS DS degradation Bcan Vcan Ncan Cspg5 Bgn Dcn Cspg4 Idua Hyal4 Hyal3 Glb1l Ids Hyal1 Gusb Glb1l3 Glb1l2 Glb1 Arsb Hexa Hexb STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 96%10223159 Sterols are 12-hydroxylated by CYP8B1 Cyp8b1 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 96%10224519 SUMOylation of nuclear envelope proteins Rangap1 Ube2i Sumo1 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 96%10224907 TP53 Regulates Transcription of Death Receptors and Ligands Igfbp3 Tmem219 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224779 FGFRL1 modulation of FGFR1 signaling Fgf17 Fgf18 Spred1 Fgf10 Spred2 Fgfrl1 Fgf2 Fgf4 Fgf23 Fgf3 Fgf5 Fgf22 Fgf8 FASL CD95L SIGNALING%REACTOME%R-RNO-75157.1 FasL CD95L signaling Casp8 Fas Fadd Faslg HDL REMODELING%REACTOME DATABASE ID RELEASE 96%10223449 HDL remodeling Apoe Lipg Pltp Lcat Alb Apoc2 Apoa1 Apoc3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223717 Trafficking of AMPA receptors Tspan7 Grip1 Prkcg Prkca Nsf Ap2m1 Myo6 Cacng8 Cacng3 Grip2 Cacng4 Prkcb Epb41l1 Cacng2 Ap2s1 Gria4 Gria3 Camk2g Camk2d Ap2a2 Gria2 Ap2a1 Camk2b Ap2b1 Pick1 Dlg1 Gria1 Dlg4 Camk2a Akap5 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-194313.1 VEGF ligand-receptor interactions Flt1 Flt4 Vegfa Kdr Vegfd Vegfc Pgf Vegfb INTERLEUKIN-1 SIGNALING%REACTOME%R-RNO-9020702.1 Interleukin-1 signaling Il1rap Map3k3 Il1rn Irak4 Irak3 Tollip Il1a Il1b Psma4 Il1r2 Il1r1 Psma3 Sqstm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Nkiras1 Psmd13 App Ikbkb Skp1 Nkiras2 Psmb5 Psmb4 Traf6 Psmb7 Peli1 Psmb6 Ikbkg Map3k8 Psmb1 Map3k7 Psmb3 Ube2n Psmb2 Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Fbxw11 Btrc Psma7 Alpk1 Rela Psmc5 Peli2 Psmc2 Psmc1 Peli3 Psmc4 Tifa Psmc3 Tnip2 S100b Myd88 Map2k6 Ubb Hmgb1-ps34 Ubc N4bp1 Psmb6l1 Psmd7 Casp8 Nfkbib Psmd6 Psmd8 Psmd2 Irak2 Psmd1 Irak1 Adrm1 Rbx1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 96%10225033 TFAP2 (AP-2) family regulates transcription of cell cycle factors Tfap2c Myc Kdm5b NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223523 Neurofascin interactions Ank1 Sdcbp Nfasc CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 96%10224457 Condensation of Prometaphase Chromosomes Smc2 Csnk2b Csnk2a2 Csnk2a1 Ncapd2 Ncapg Smc4 Ncaph REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-RNO-350562.1 Regulation of ornithine decarboxylase (ODC) Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Odc1 Oaz1 Psmd12 Oaz3 Psmd11 Oaz2 Psmd14 Nqo1 Psmd13 Azin1 Psmb5 Psmb4 Psmb7 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222599 Activation of BMF and translocation to mitochondria Dynll2 Bmf Mapk8 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224075 Termination of O-glycan biosynthesis St6galnac3 St6galnac2 St3gal4 St3gal2 St3gal3 St3gal1 Muc15 Muc13 St6gal1 Muc19 Muc5b Muc4 Muc6 RHOV GTPASE CYCLE%REACTOME%R-RNO-9013424.1 RHOV GTPase cycle Wdr6 Txnl1 Pak6 Rhov Ccp110 Pak4 Git2 Arhgap12 Epha2 Zfp512b Dlg5 Myo9a Nck1 Dst Sh3rf1 Map3k11 Arhgef7 Cltc Nck2 Pak1 Git1 Sptbn1 Pak2 Pard6b Tpm4 Pard6a Sptan1 Pik3r1 Depdc1b Cdc42 Usp9x Peak1 Cep97 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-RNO-1247673.1 Erythrocytes take up oxygen and release carbon dioxide Slc4a1 Aqp1 Ca1 Ca2 Ca4 Hba1 Hbb Rhag METABOLISM OF RNA%REACTOME%R-RNO-8953854.1 Metabolism of RNA Sde2 LOC120093247 Heatr1 Slu7 Nob1 Srrm2 Dcps Utp11 Zfp36l1 Ddx52 Nkap Rpl36a Hnrnph2 Utp18 Wdr43 Hnrnph1 Rrp7a Prpf6 Noc4l Khsrp Dis3 Zmat5 Rplp2 Ppig Tex10 Ppie Riok1 Rbmx2 Riok2 Cwc22 AABR07072440.1 Cwc27 Gnl3 Cwc25 Rpl35al8 Prpf8 Wbp11 Ddx49 Wdr36 Papolg Rpl22l1 Ppp1r8 Rplp0 Snip1 Cwc15 Ddx47 Rplp1 Nt5c3b Pan2 Rpl13a Rpl35al2 Pan3 Rpl18a Rbm25l1 Nip7 Gpatch1 Rpl13 Magohb Rpl14 Ddx6 Rrp36 Pqbp1 Rpl15 Qng1 Prr3 Mphosph6 Nol9 Ybx1 Rpl17 Dnajc8 Rbm26 Rpp14 Rpl18 Rbm25 Rpl19 Rbm27 Nol6 Rbm7 Utp14a Rbm5 Mphosph10 Rbm22 Rpl10 Rbm17 Pes1 Ddx46 Rpl11 Bud31 Ddx41 Bms1 C1d Ddx42 Rpl12 Wtap Cwf19l2 Rpl10a Exosc9 Poldip3 Exosc8 Tnfsf13 Exosc5 Nxf5 Krr1 Rbmx Exosc4 Nxf7 Exosc7 Tra2b Exosc6 Acin1 Exosc1 Bud13 Utp3 Ddx23 Exosc3 Utp4 Exosc2 Utp6 Nop58 Nop56 Bop1 LOC134480579 Ebna1bp2 Wdr18 Tsr1 Ddx21 Rpl23a Wdr12 Ppp1cb Mapkapk2 Ywhab Akt1 Ppp2r2a Hspa8 Rps6 Eif4e Rps2 Rps27 Yrdc Wdr82 Xpo1 Rbbp6 Nup93 Nup50 Gemin6 Snrpf Gemin7 Nup35 Nup54 Nup98 Snrpg Gemin5 Snrpb Nup58 Gemin8 Nup37 Pom121 Prmt5 Nup205 Nup107 Sec13 Tgs1 Nup188 Tpr Smn1 Nup160 Rae1 Snupn Ndc1 Snrpd1 Clns1a Nup85 Nup42 Nup62 Nup43 Nup88 Gemin7l1 Aaas Snrpd3 Ranbp2 Csnk1e Nup214 Gemin2 Ywhaz Nup133 Nup210 Nup155 Nup153 Ddx20 Snrpepl2 Wdr77 Hspa1b Hspa1a Pcf11 Fip1l1 Cstf1 Zfp473 Papola Nudt21 Polr2c Cstf2 Polr2a Cstf3 Polr2b Cstf2t Polr2g Lsm10 Polr2h Lsm11 Sympk Polr2e Pabpn1 Polr2f Clp1 Cpsf4 Polr2i Cpsf6 Cpsf7 Polr2j Cpsf1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Alyref Nxf1 Slbp Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Rps14 Psmd13 Rps15 Rps16 Rps17 Rps15a Rps18 Rps19 Pabpc1 Psmb5 Rpsa Psmb4 Rps10 Psmb7 Rps11 Psmb6 Rps13 Rps4x-ps13 Psmb1 Rps3a Psmb3 Rps27l Psmb2 Rps9 Uba52 Rps7 Rps8 Rps5 Rps26-ps13 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Dhx9 Rps3 Rps25 Rps4x Rps26 Rps28 Ubb Rps29 Rps20 Ubc Rps21 Rps23 Psmb6l1 Rps24 Eif4a2 Psmd7 Eif4a1 Psmd6 Fau Psmd8 Psmd2 Psmd1 Adrm1 Ppp1ca Ppp2ca Prkcd Prkca Ppp2r1a Csnk1d Snrnp200 Phf5a Fam50a Gle1 Znf830 Fyttd1 Anp32a Hnrnpr-ps2 Rnf113a1 U2surp Crnkl1 Rnf113a2 Skic3 Skic2 Skic8 Parn Upf3b Sarnp Upf3a Set Wdr70 Snrpa1 Mettl3 Steep1 C3h9orf78 Ptbp1 A1cf Ccnh Eif4a3 Rnpc3 Ppwd1 Smg1 Smg9 Smg8 Adarb1 Smg7 Adar Gcfc2 Smg6 Smg5 Ccdc12 Paip1 Upf1 Upf2 Rbm8a Tut1 Sf3a1 Sf3a2 Sf3a3 Prkrip1 Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Leng1 Mfap1al1 Ctnnbl1 Cactin Cdk7 Edc3 Edc4 Zcchc8 Thoc2 Zfc3h1 Thoc3 Hnrnpa2b1 Thoc5 Thoc6 Thoc7 Zfp36 Rnmt Srrt Mnat1 Snrnp70 Nsrp1 Zcrb1 Prpf19 Htatsf1 Snrnp40 Prpf18 Eftud2 Snrnp48 Fam32a Snrpa Snrpc Snrpn Chtop Zc3h18 Cherp Yju2 Fus Lsm3 Lsm5 Lsm1 Lsm6 Zc3h4 Lsm7 Zc3h3 Casc3 Isy1 Nxt1 Cdc5l Snrnp25 Ythdc2 Ythdc1 Srsf1 Plrg1 Rpl4 Patl1 Rpl5 Srsf9 Rpl3 Srsf7 Las1l Srsf5 Srsf3 Ltv1 Rpl35 Srsf2 Snrnp35 Fcf1 Rpl36 Hnrnpa3 Rpl37 Syf2 Rpl38 Etf1 Rpl39 Puf60 Rpl8 U2af1 Rpl9 Ppil4 Rrp9 Ppil3 Rpl6 Hnrnpa1 Ppil2 Pwp2 Rpl7 Ppil1 Sap18 Rpp38 Bysl Pnrc2 U2af1l4 Fbl Rpl30 Tcerg1 LOC134486107 Tnpo1 Rpl31 Bcas2 Rpl32 Pdcd7 Gpkow Rpp30 Rpl34 Rngtt Rpl36al1 Rnps1 Ftsj3 Smndc1 Pnn Rpl39l1 Rpl24 Prpf40a Rpl26 Cdc40 Ddx39a Imp4 Rpl27 Aqr Rpl28 Prcc Rpl29 Pcbp2 Pcbp1 Rpp25 Rpl12-ps1 Magoh Ncl Ddx39b Rpl22 Dcp1a Dcp1b Xrn2 Rpl23 Xrn1 Snu13 Gspt2 Wdr75 Tfip11 Senp3 Gspt1 Dhx8 Isg20l2 Exosc10 Hnrnpr Hnrnpu Emg1 Rbm10 Eri1 Dhx38 LOC120097744 Dhx37 Dhx35 Elavl1 Rpl36l5 Mettl14 Rpl36l3 Rpl3l Apobec4 Pdcd11 Apobec2 Pno1 Apobec3 Rpl27a Sugp1 Rpl31l15 Apobec1 Zrsr2 Utp20 Nop14 Hnrnpc Pelp1 Hnrnpd Hnrnpf Rcl1 Hnrnpk Hspb1 Utp25 Tbl3 Hnrnpl Nol11 Dcp2 Hbs1l Rpp40 LOC100910714 Dhx16 LOC102551819 Dhx15 Wdr3 Srsf19 Srsf11 Bud23 Srsf12 Dcaf13 Srrm1 Utp15 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-RNO-9959399.1 SLC-mediated transport of oligopeptides Slc15a1 Ctns Slc15a3 Slc15a4 RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-RNO-5626467.1 RHO GTPases activate IQGAPs Cdh1 Ctnna1 Men1 Clip1 Calm3 Rac1 Ctnnb1 Cdc42 Iqgap2 Iqgap3 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-RNO-446210.1 Synthesis of UDP-N-acetyl-glucosamine Amdhd2 Uap1 Gfpt1 Gfpt2 Pgm3 Renbp Nagk Gnpnat1 MRNA EDITING: C TO U CONVERSION%REACTOME%R-RNO-72200.1 mRNA Editing: C to U Conversion Apobec1 A1cf Apobec4 Apobec2 Apobec3 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 96%10222349 Beta oxidation of octanoyl-CoA to hexanoyl-CoA Acadm Hadha Hadhb Echs1 Hadh MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%10222251 mRNA Splicing Sde2 Slu7 Srrm2 Snrpepl2 Nkap Hnrnph2 Hnrnph1 Prpf6 Zmat5 Ppig Ppie Rbmx2 Cwc22 Cwc27 Cwc25 Prpf8 Wbp11 Snip1 Cwc15 Gpatch1 Magohb Pqbp1 Ybx1 Rbm22 Rbm17 Ddx46 Bud31 Ddx41 Ddx42 Cwf19l2 Rbmx Polr2c Tra2b Polr2a Acin1 Polr2b Bud13 Polr2g Ddx23 Polr2h Polr2e Polr2f Polr2i Polr2j Ncbp2 Ncbp1 Gtf2f2 Gtf2f1 Snrnp200 Phf5a Fam50a Znf830 Hnrnpr-ps2 Alyref Rnf113a1 U2surp Crnkl1 Rnf113a2 Upf3b Wdr70 Snrpa1 Steep1 C3h9orf78 Ptbp1 Eif4a3 Rnpc3 Ppwd1 Gcfc2 Ccdc12 Rbm8a Sf3a1 Sf3a2 Sf3a3 Prkrip1 Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Leng1 Mfap1al1 Ctnnbl1 Cactin Hnrnpa2b1 Srrt Nsrp1 Zcrb1 Prpf19 Snrnp40 Prpf18 Eftud2 Snrnp48 Fam32a Snrpn Cherp Yju2 Fus Casc3 Isy1 Cdc5l Snrnp25 Srsf1 Plrg1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Snrnp35 Hnrnpa3 Syf2 Puf60 Ppil4 Ppil3 Hnrnpa1 Ppil2 Ppil1 Sap18 Hspa8 Bcas2 Pdcd7 Gpkow Rnps1 Smndc1 Pnn Cdc40 Aqr Prcc Pcbp2 Snrpf Pcbp1 Magoh Ddx39b Snrpg Snrpb Tfip11 Dhx8 Hnrnpr Hnrnpu Rbm10 Dhx38 Dhx35 Zrsr2 Hnrnpc Snrpd1 Hnrnpd Hnrnpf Hnrnpk Hnrnpl Dhx16 Dhx15 Srsf19 Snrpd3 Srsf11 Srsf12 Srrm1 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-RNO-9609523.1 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Serp1 Sgta Stx1a Hmox1 Aldh3a2 Sec61gl4 Vapa Stx5 Emd Vamp2 App Cyb5a Ube2j2 Prnp RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%10222237 RNA Polymerase I Transcription Termination Gtf2h2 Gtf2h1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Cavin1 Ttf1 Polr1c Mnat1 Tbp Polr1b Polr1a Ccnh Polr1f Polr1g Polr1e Polr1h Taf1d Taf1a Taf1c Taf1b Polr2h Polr2e Polr2f Ubtf REGULATION OF RAS BY GAPS%REACTOME%R-RNO-5658442.1 Regulation of RAS by GAPs Rasal3 Syngap1 Spred1 Spred3 Spred2 Rasa2 Rasa1 Rasa4 Rasa3 Psma4 Psma3 Psma6 Psma5 Psma2 Nras Psma1 Rps27a Psmd12 Psmd11 Kras Psmd14 Hras Psmd13 Kbtbd7 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Dab2ip Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Nf1 Cul3 Rasal1 Rasal2 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-RNO-191650.1 Regulation of gap junction activity Tjp1 Src Gja1 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-RNO-5357956.1 TNFR1-induced NF-kappa-B signaling pathway Ikbkg Map3k7 Traf2 Sharpin Tnf Otud1 Tnfrsf1a Birc2 Traf1 Spata2 Rnf31 Rack1 Usp2 Xiap Usp4 Tradd Cyld Optn Ripk1 Tab3 Otud7b Tab2 Tab1 Rbck1 Chuk Ikbkb Usp21 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-RNO-2162123.1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Cyp8b1 Akr1c18 Ptges3 Akr1c12l1 Akr1c19 Akr1c21 Cbr1 Tbxas1 Ptges Ptgds Ptgis Ptges2 Ptgs1 Akr1c3l1 Ptgs2 Akr1c12 Hpgds Akr1c1 Akr1c13 Akr1c9 CENTROSOME MATURATION%REACTOME%R-RNO-380287.1 Centrosome maturation Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Cdk11b Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Dync1h1 Csnk1d Ccp110 Dync1i2 Nde1 Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Tubg2 Clasp1 Tubg1 Ywhae Cep63 Nme7 Cep152 Tuba4a Plk1 Tubgcp2 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Tubgcp6 Cdk1 Tubgcp5 Tubgcp4 Tubgcp3 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 Mzt1 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-372708.1 p130Cas linkage to MAPK signaling for integrins Fgb Apbb1ip Fga Bcar1 Fgg Itga2b Ptk2 Src Tln1 Rap1a Rap1b Fn1 Itgb3 Crk PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 96%10224437 Phosphate bond hydrolysis by NUDT proteins Nudt5 Nudt9 Nudt16 Nudt18 Adprm Nudt1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-RNO-187577.1 SCF(Skp2)-mediated degradation of p27 p21 Psmb6 Psmb1 Ccnd1 Psmb3 Psmb2 Uba52 Cks1b Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Cdkn1b Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Ccna1 Psmd1 Psma3 Adrm1 Ccna2 Cul1 Cdk2 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Psmd13 Skp2 Cdk4 Skp1 Psmb5 Psmb4 Ptk6 Psmb7 SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 96%10225453 Signaling by LTK Grb2 Pik3r2 Pik3ca Shc1 Sos1 Irs1 Ltk Tnk2 Alkal2 Alkal1 Pik3r1 Pik3cb PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-RNO-72203.1 Processing of Capped Intron-Containing Pre-mRNA Sde2 Nup133 Nup210 Slu7 Srrm2 Nup155 Nup153 Nkap Snrpepl2 Hnrnph2 Hnrnph1 Prpf6 Zmat5 Ppig Ppie Rbmx2 Cwc22 Cwc27 Cwc25 Prpf8 Wbp11 Papolg Ppp1r8 Snip1 Cwc15 Rbm25l1 Gpatch1 Magohb Pqbp1 Prr3 Ybx1 Dnajc8 Rbm25 Rbm5 Rbm22 Rbm17 Ddx46 Bud31 Ddx41 Ddx42 Wtap Cwf19l2 Pcf11 Poldip3 Fip1l1 Cstf1 Nxf5 Rbmx Papola Nxf7 Nudt21 Polr2c Tra2b Cstf2 Polr2a Acin1 Cstf3 Polr2b Bud13 Polr2g Cstf2t Ddx23 Polr2h Sympk Polr2e Polr2f Pabpn1 Clp1 Cpsf4 Polr2i Cpsf6 Cpsf7 Polr2j Cpsf1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Gtf2f2 Gtf2f1 Ppp1cb Alyref Nxf1 Slbp Rps27a Uba52 Hspa8 Dhx9 Ubb Ubc Eif4e Ppp1ca Snrnp200 Phf5a Fam50a Gle1 Znf830 Fyttd1 Hnrnpr-ps2 Rnf113a1 U2surp Crnkl1 Rnf113a2 Upf3b Sarnp Wdr70 Snrpa1 Mettl3 Steep1 C3h9orf78 Ptbp1 Eif4a3 Rnpc3 Ppwd1 Gcfc2 Ccdc12 Rbm8a Tut1 Sf3a1 Sf3a2 Sf3a3 Prkrip1 Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Leng1 Mfap1al1 Ctnnbl1 Cactin Thoc2 Thoc3 Hnrnpa2b1 Thoc5 Thoc6 Thoc7 Srrt Snrnp70 Nsrp1 Zcrb1 Prpf19 Htatsf1 Snrnp40 Prpf18 Eftud2 Snrnp48 Fam32a Snrpa Snrpc Snrpn Chtop Cherp Yju2 Fus Casc3 Isy1 Nxt1 Cdc5l Snrnp25 Srsf1 Plrg1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Snrnp35 Hnrnpa3 Syf2 Puf60 U2af1 Ppil4 Ppil3 Hnrnpa1 Ppil2 Rbbp6 Ppil1 Sap18 U2af1l4 Tcerg1 Bcas2 Pdcd7 Gpkow Rnps1 Smndc1 Pnn Prpf40a Cdc40 Ddx39a Nup93 Aqr Nup50 Prcc Pcbp2 Snrpf Pcbp1 Magoh Nup35 Ddx39b Nup54 Nup98 Snrpg Snrpb Tfip11 Nup58 Dhx8 Nup37 Hnrnpr Pom121 Hnrnpu Nup205 Rbm10 Nup107 Dhx38 Dhx35 Sec13 Mettl14 Nup188 Tpr Nup160 Sugp1 Rae1 Zrsr2 Ndc1 Hnrnpc Snrpd1 Hnrnpd Hnrnpf Nup85 Hnrnpk Nup42 Hnrnpl Nup62 Nup43 Nup88 Dhx16 Aaas Dhx15 Srsf19 Snrpd3 Ranbp2 Srsf11 Nup214 Srsf12 Srrm1 VLDL ASSEMBLY%REACTOME%R-RNO-8866423.1 VLDL assembly P4hb Apob Mttp Apoc1 Apoc4 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10223353 NOSIP mediated eNOS trafficking Nos3 Nosip ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 96%10221921 Activation of the pre-replicative complex Cdc6 Mcm7 Mcm8 Dbf4 Mcm3 Mcm4 Mcm5 Mcm10 Mcm2 Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Pole Pola2 Cdk2 Pola1 Prim2 Prim1 Orc4 Orc6 Orc1 Orc3 Orc2 Cdt1 Gmnn Cdc7 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME DATABASE ID RELEASE 96%10224895 TP53 Regulates Transcription of DNA Repair Genes Polr2j Ctdp1 Gtf2h2 Gtf2h1 Supt4h1 Eloc Gtf2f2 Gtf2f1 Elob Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Nelfcd Ell Ccnk Tcea1 Ccnt2 Cdk13 Cdk12 Cdk9 Ssrp1 Eloa2l Mnat1 Eloa Ccnh Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 96%10224085 Factors involved in megakaryocyte development and platelet production Dock2 Prkaca Prkacb Racgap1 Prkar1a Prkar1b Kif18b Kif19 Kif26b Kifc1 Kifc2 Kif3a Kif26a Hdac1 Rbsn Rcor1 Jmjd1c Kif11 Kif12 Akap1 Kif15 Akap10 Prkar2a Rac1 Kif5a Prkar2b Kif5b Kif21a Kif1c Ak3 H3-3b Kif21b Kif13b Kif1a Kif1b Kif6 Zfpm2 Dock5 Dock6 Kif9 Dock3 Dock4 Dock7 Dock8 H2bc18 Gata5 Kif22 Kif23 Gata4 Kif28 Kdm1a Kif27 Kif16b Kif18a Kif20a Klc1 Kif20b Hmg20b Kifap3 Itpk1 Maff Klc4 Rab5a Mafg Klc3 Klc2 Nfe2 Cbx5 Kif3b Dock10 Dock11 Kif3c Vps45 Rad51c Sh2b2 Sh2b1 Rad51b Ehd1 Ehd2 Ehd3 Gata6 Cenpe Mfn1 Hdac2 Jak2 Mfn2 Kif2a Kif2b Kif2c Kif4b Zfpm1 Kif4a Gata3 Gata1 Gata2 Cdc42 HEMOSTASIS%REACTOME DATABASE ID RELEASE 96%10222561 Hemostasis Prkcq Rasgrp1 Tln1 Fn1 Pdgfa Pdgfb Prkg2 Ptk2 Mapk3 Nras Grb2 Fyn Rap1a Kras Sos1 Rap1b Hras App Ppp2r5b Ppp2r5a Apbb1ip Cd36 Ppp2r5e Nos2 Hgf Hdac2 Vcl Tuba4a Mapk14 Prkcb Kif4b Kif4a L1cam Lat Itgav Tgfb1 Angpt1 Tgfb2 Tgfb3 Fgb Fga Fgg Itga2b Csk Egf Itgb1 Tek Serping1 Kif18b Itgb3 Kif19 Clu Kif26b Kifc1 Kifc2 Kif26a Rbsn Rcor1 Jmjd1c Kif11 Kif12 Akap1 Kif15 Akap10 Kif5a Kif5b Kif21a Kif1c Ak3 Kif21b Akt1 Kif13b Kif1a Kif1b Kif6 Zfpm2 Dock5 Dock6 Tf Kif9 Dock3 Dock4 Dock7 Dock8 Gata5 Kif22 Kif23 Gata4 Kif28 Kif27 Kif16b Kif20a Klc1 Kif20b Hmg20b Kifap3 Itpk1 Maff Klc4 Rab5a Mafg Klc3 Klc2 Nfe2 Cbx5 Kif3b Dock10 Dock11 Kif3c Vps45 Sh2b2 Sh2b1 Ehd1 Ehd2 Ehd3 Phactr2 Stxbp2 Cxadr Stxbp3 Selplg Plcg2 Tfpi Itgax Vti1b Chid1 Abcc4 Prkch Prkce S100a10 Cfd A1bg Gp6 Agrn Gp5 Glg1 Rab27b Gp9 F13b Prkg1 Serpine1 Islr Pcyox1l Hrg Olr1 Slc16a3 Slc16a8 Mgll Slc16a1 F3 F7 F9 Lhfpl2 Pik3r6 Gas6 Sytl4 Ly6g6f Ceacam1 Ahsg Crk Spp2 Stx4 Jam3 Jam2 Serpina3n F10 F12 F11 Timp3 Serpinb6a Grb14 Fam3c Mpig6b Jaml Dgka Serpinf2 Dgkb Abhd6 Dgkd Dgke Dgkg F13a1 Anxa5 Serpine2 Anxa2 Qsox1 Itga3 Itga4 Brpf3 Esam Lgals3bp Dgkh Dgki Dgkk Lamp2 Dgkq Serpina10 Cd177 Dgkz Pde5a Itpr3 Itpr2 Itpr1 Pde10a Atp2a1 Wdr1 Atp2a3 Lyn Atp2a2 Daglb Yes1 Maged2 Src Spn Rhoa Trpc7 Trpc3 Endod1 Itgal Serpinb2 Atp2b1 Atp2b4 Atp2b3 Serpina5 Serpina4 Dagla Itgb2 Lcp2 Actn2 Habp4 Sri Cd244 Serpind1 Cdc37l1 Slc3a2 Mertk Atp1b1 Pde11a Atp1b3 Arrb2 Atp1b2 Arrb1 Tagln2 Thbd Smpd1 Itih4 P2rx6 Itih3 P2rx5 P2rx4 P2rx3 P2rx2 P2rx1 Rad51c Pros1 Serpinc1 Rad51b Aamp Trem1 Cd109 Nhlrc2 Mif Lck Fermt3 Lefty2 Thbs1 Manf AABR07021573.2 Lefty1 Pafah2 Igf2 Igf1 Sparc Apoh Raf1 Jak2 Gtpbp2 Orm1 Ecm1 Rhog Ola1 Rhob Gp1bb Ctsw Rac2 Gp1ba Ano6 Ano5 Actn4 Slc7a11 Slc7a10 Flna Cd48 Cd47 Irag1 Slc7a6 Tmsb4x Itga6 Slc7a7 Cd63 Slc7a5 Slc7a8 Slc7a9 Tor4a Cd74 Prtn3 Clec1b F11r Slc8a1 Slc8a2 Ppia Procr Slc8a3 Epcam Dok2 Tmx3 Fcer1g Pdpn Scg3 Sele Pde9a Proc Selp Sell Jchain Cyrib Abhd12 Sccpdh Plat Sirpa Plau Srgn Pde2a Pecam1 Nos1 Angpt2 Angpt4 Actn1 Proz Aplp2 Fcamr Cyb5r1 Mmrn1 Inpp5d Cd9 Pik3ca Plek Shc1 Sod1 Cav1 Ptpn6 Pik3r1 Pik3cb Plaur Pik3r2 Pik3r3 Kif18a Pik3r5 Pik3cg Cenpe Mfn1 Mfn2 Kif2a Kif2b Kif2c Ywhaz Aldoa Pdpk1 Alb Kif3a Apoa1 Apob Sdc4 Sdc3 Sdc2 Lrp8 Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Gpc6 Sdc1 Bcar1 Ptpn1 Rapgef4 Rapgef3 P2rx7 Rasgrp2 Tbxa2r Ppbp Bsg Dock2 Pcdh7 Plcg1 Plg Klkb1 Racgap1 Cd44 Timp1 Mmp1b Rac1 A2m F2 Kdm1a Pf4 Mapk1 Nos3 Pla2g4a P2ry12 Gng10-ps1 Mag F2rl2 F2rl3 Ppp2cb Grb7 Ppp2ca Adra2b Prkaca Prkacb Prkcg Prkcd Gnai2 Gnai1 Prkca Gnai3 Gna11 Prkar1a Gna14 Prkar1b Calm3 Ppp2r5d Gng3 Vegfa Vegfd Gng5 Vegfc Gng4 Vegfb Gnaq Gng7 Gng8 Gngt1 Gnat3 Prkar2a Prkar2b F2r Ppp2r1b Ppp2r1a Pde1b Gnb2 Gnb1 Pde1a Gnb4 Kng1 Gnb3 Gnb5 Gng11 F8 Serpina1 Adra2a Adra2c Gata6 Ptgir Psap Zfpm1 Gata3 Gata1 Gata2 P2ry1 Actg1 Hdac1 H3-3b Vav3 Vav1 Vav2 Ptpn11 H2bc18 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 Gna13 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Ppil2 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Fgr ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Cdc42 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 96%10223601 Regulation of IGF Activity by IGFBP Ttgn1 Men1 Igfbp3 Fn1 Qsox1 Alb Serpina10 Notum Apoa1 Apoa2 Kng1 Mia3 Apoe P4hb Apob App Fgf23 Sdc2 Serpind1 Serpina1 Gpc3 Serpinc1 Ckap4 Igf2 Igf1 Cdh2 Il6 Prkcsh Adam10 Ctsg ENSRNOG00000069479 Gzmf C3 Hsp90b1 Fga Fgg Scg3 Ltbp1 Proc Plg Spp1 Bmp4 Ktn1 Fbn1 Aplp2 C4b Timp1 Megf11 Chgb ENSRNOG00000067174 Mmp1b Pdia6 C4 Ccn1 Amelx Pappa Lgals1 Csf1 Scg2 Apoa5 Meltf Mxra8 Fam20a LOC120093819 Fam20c Tf Klk6 Fuca2 Stc2 Wfs1 Apol7al1 Hrc Pcsk9 Ngfg F2 Ambn Mepe Cp Pappa2 Dnajc3 Apol2 Enam Bmp15 Bpifb2 Apol7bl1 Ano8 Penk Igfbp7 Igfbp6 Igfals Mfge8 Matn3 ENSRNOG00000066972 Rcn1 Vgf Vwa1 Fstl1 Fstl3 Chrdl1 Prss23 Tmem132a Afp Pnpla2 Mbtps1 Igfbp2 Igfbp5 Igfbp4 Tnc Golm1 Igfbp1 Amtn Dmp1 Mgat4a Nucb1 Sparcl1 Mmp2 Msln Vcan Cst3 Itih2 Apol9a Klk13 Gas6 Ahsg Spp2 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%10224661 ATP-dependent chromatin remodelers Snrpepl2 Ctnnb1 Rbbp4 Rbbp7 Rbm17 Ddx46 Ddx42 Cdc73 Chd8 Leo1 Ube2i Phf5a U2surp Skic8 Hdac2 H2ab2 Snrpa1 Arid1a Arid1b H2ac4 Actl6a Smarce1 ENSRNOG00000066901 Sf3a1 Sumo1 Sf3a2 Sf3a3 Sf3b1 Sf3b3 Sf3b4 Sf3b5 H2ac18 Ss18 Dpf1 Bicral Bicra Ssrp1 Dpf2 Dpf3 Pbrm1 Brd9 Brd7 Actg1 Hist1h2bq Ss18l1 Smarcb1 Bcl7a Hdac1 Bcl7b Wdr5 Bcl7c Bcl11a Bcl11b Phf10 Snrpn H2aj Cherp Smarca2 Smarca4 H3-3b Hist3h2ba ENSRNOG00000068602 Chd3 Chd4 Smarcd1 Smarcd3 Mbd2 Smarcd2 Mta1 H2bc18 Mta2 Mta3 Mbd3 H2az2 Cbx3 H2bc4 Hist1h4m Gatad2a H2bc1 Gatad2b Smarcc1 Hist1h2ai Puf60 Smndc1 Snrpf Snrpg Snrpb Nr2c2 Fam124b Zmynd8 Ikzf3 Ikzf1 Zfp827 Zfp532 Adnp Cbx1 Ctr9 Paf1 Phf6 Zfp592 Ctcf Cdk2ap1 Snrpd1 Nr2f2 Chd1 Chd2 Chd5 Chd6 Chd7 Tcf19 Dhx15 Pwwp2a Snrpd3 Mbd3l1 Mbd3l2 Zfp687 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%10222681 Cytosolic sulfonation of small molecules Tpst1 Tpst2 Sult2b1 Sult1a1 Sult1c2 Sult1b1 Bpnt2 Sult6b1 Sult4a1 Sult2a2 Bpnt1 Sult2a1 Sult2a6 Abhd14b Podxl2 Sult1e1 NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223547 NCAM1 interactions St8sia4 Col4a1 Col4a2 Ncam1 St8sia2 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-RNO-1638091.1 Heparan sulfate heparin (HS-GAG) metabolism Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Gpc6 Idua Naglu Ids Hpse2 Hpse Sgsh Sdc1 Ctsl Hs3st4 Hs3st1 Hs3st2 Extl2 Hs3st5 Hs3st6 Hs3st3b1 Hs2st1 Ndst1 Ndst2 Ndst3 Ndst4 Agrn Hs3st3a1 Hs6st3 Hs6st2 Hs6st1 Ext2 Ext1 Slc35d2 Sdc4 Sdc3 Sdc2 MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 96%10225047 MET activates PTPN11 Hgf Grb2 Ptpn11 Met Gab1 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 96%10225353 Inactivation of CSF3 (G-CSF) signaling Jak2 Uba52 Eloc Ube2d1 Elob Syk Lyn Socs3 Rps27a Hck Csf3 Tyk2 Cul5 Ube2d3 Ube2d2 Ubb Socs1 Ubc DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222475 DAG and IP3 signaling Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkce Prkar2a Prkar2b Pde1b Pde1c Pde1a Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10222835 MyD88 cascade initiated on plasma membrane Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 INTERCONVERSION OF POLYAMINES%REACTOME%R-RNO-351200.1 Interconversion of polyamines Smox Sat1 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 96%10222245 Signaling by Rho GTPases Mtr Ywhag Frs2 Frs3 Acbd5 Sptbn1 Ptk2 Aldh3a2 Mapk3 Sptan1 Emd Grb2 Rbmx Sos1 Tra2b Usp9x Iqgap2 Ppp2r5b Ppp2r5a S100a9 Ppp1cc Abcd3 Ppp1cb Ppp2r5e Map3k11 Mapk14 Prkcb Rasgrf2 Mapk11 Ywhab Rasal2 Ncoa2 Csk Itgb1 Atp6ap1 Kif5a Kif5b Dock5 Dock6 Steap3 Dock3 Dock4 Dock7 Tfrc Dock8 Pik3c3 Klc1 Pik3r4 Klc4 Klc3 Klc2 Dbt Dock10 Dock11 Rab7a Ywhae Lamtor1 Lbr Kidins220 Als2 Gopc Rhoq Vamp3 Sh3rf1 Ckb Snap23 Pde5a Pak1 Pak2 Tpm4 Rhoa Ngef Mylk Dlg4 Ncf1 Zap70 Ncf2 Ncf4 Lck AABR07021573.2 Rhog Rhob Pard6b Pard6a Rac2 Fermt2 Flna Cyba Cybb Dst Actn1 Pik3ca Arhgap32 Cav1 Farp2 Pik3r1 Pik3r2 Pik3r3 Pafah1b1 Zw10 Knl1 Ska2 Ska1 Zwint Sfn Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Rbbp6 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Sgo2 Sgo1 Nup107 Cdc25c Sec13 Kif2a Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Ywhaq Ywhah Birc5 Aaas Ercc6l Ranbp2 Ckap5 Ywhaz Spdl1 Nup133 Bub1 Itgb3bp Hmox2 Zwilch Pdpk1 Ctnnb1 Men1 Garre1 Shmt2 AABR07032856.1 Osbpl11 Nisch Uaca Nckap1l Wipf3 Wipf1 Itsn2 Dvl1 Mrtfa Dvl2 Stmn2 Dvl3 Scrib Jag1 Fam83b Fam91a1 Mtmr1 Nox3 Nox1 Flot2 Samm50 Flot1 Fam169a Amigo2 Noxa1 Baiap2l2 Rapgef1 Baiap2l1 Letm1 Golga3 Gps1 Fgd5 Taok3 Ralgapa1 Cdc37 Chn2 Esyt1 Trip10 Wwp2 Fam135a Abi2 Abi1 Wdr11 Tuba1b Msi2 Ppp1r12b Stip1 Cpsf7 Ppp1r12a Phip Akap12 Stk38 Vrk2 Ppp1r14a Abl2 Slc1a5 Lin7b Cops4 S100a8 Arpc3 Cops2 Arpc2 Srgap1 Ubxn11 Arhgap45 Slk Cpd Cdh1 Arpc5 Cavin1 Daam1 Ctnna1 Arpc4 Pgrmc2 Picalm Tex2 Brk1 Bcr Ndufs3 Arhgap6 Jup Dsp Arhgap5 Arhgap15 Arhgap4 Arhgap17 Dsg1 Sowahc Arhgap1 Dsg2 Stom Evl Arap1 Rhobtb2 Arap3 Rhobtb1 Arap2 Arhgap25 Arhgap9 Srf Arhgap8 Arhgap27 Mcam Slitrk5 Slitrk3 Pld1 Arhgap33 Ccdc115 Wasf3 Rtkn Wasf2 Rhpn1 Hsp90ab1 Wasf1 Rhpn2 Stk10 Plekhg1 Ralbp1 Stard8 Prc1 Maco1 Rnf20 Ddrgk1 Cct6a Faf2 Cdc42bpa Arhgdib Gmip Cdc42bpb Slc4a7 Anln Arhgap10 Arpc1b Actr2 Iqgap3 Arpc1a Diaph3 Actr3 Diaph1 Arhgap19 Btk Arhgap18 Pfn1 Depdc1b Senp1 Cit Pfn2 Vangl2 Fam13a Arhgef28 Twf1 Epsti1 C1qbp Arhgap22 Cpne8 Arhgap21 Nckap1 Arhgap20 Nipsnap2 Arhgap26 Ankle2 Arhgap24 Cyfip2 Arhgap23 Cyfip1 Arhgap29 Rhoh Arhgap28 Rhof Rhoc Ophn1 Rhoj Stbd1 Rac3 Dock2 Def6 Kif14 Vapb Rhou Pcdh7 Fam13b Scai Myo9b Nckipsd Emc3 Arhgap11a Cct7 Pak5 Myo9a Arhgap31 Ccdc88a Arhgap30 Tmem59 Prex2 Mtx1 Noxo1 Actc1 Arhgap35 Mpp7 Ankrd26 Fmnl3 Tagap Srgap2 Racgap1 Srgap3 Plekhg6 Ocrl Tmod3 Tmem87a Plekhg3 Cdc42ep1 Bcap31 Cdc42ep4 Ktn1 Plxna1 Farp1 Syde1 Dlc1 Syde2 Pld2 Stard13 Arhgap40 Elmo2 Pkn2 Rras2 Rock2 Arhgef7 Dnmbp Rock1 Nsfl1c Pkn1 Ccdc187 Arhgap44 Plxnd1 Arhgap42 Basp1 Tjp2 Ddx4 Spata13 Kdm4c Nck2 Rnd2 Rac1 Rnd3 Pak3 Rnd1 Git1 Swap70 Arhgdig Baiap2 Kctd13 Fnbp1 Bltp3b Spen Hsp90aa1 Armcx3 Ndufa5 Add3 Tor1aip1 Sema4f Lmnb1 Ptpn13 Fmnl2 Fmnl1 Sh3bp1 Prag1 Limk1 Vim Cdc20 Hspe1 Kdm1a Tnfaip1 Mad2l1 Bub1b Nck1 Aurkb Actb Prkcz Plk1 Mapk1 Stam Ar Mcf2 Arhgdia Cftr Lman1 Scfd1 Ppp2cb Grb7 Ppp2ca Prkcd Arfgap3 Prkca Calm3 Ppp2r5d Hgs Ppp2r1b Ppp2r1a Stam2 Muc13 Peak1 Cep97 Wdr6 Txnl1 Pak6 Rhov Pak4 Ccp110 Git2 Arhgap12 Epha2 Zfp512b Dlg5 Stx5 Ykt6 Ckap4 H2ab2 H2ac4 Arl13b Abl1 ENSRNOG00000066901 Cct2 H2ac18 Hist1h2bq Actg1 Ptk2b H2aj Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 H3-3b Arhgef16 Hist3h2ba Arhgef11 Arhgef10 Arhgef12 ENSRNOG00000068602 Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 H2bc18 H2az2 Sos2 Kalrn H2bc4 Hist1h4m H2bc1 Arhgef6 Hist1h2ai Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Abr Fgd3 Arhgef39 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Gja1 Ddx39b Myo6 Cltc Vcp Hnrnpc Cdc42ep2 Cdc42ep3 Cdc42 Cul3 Srrm1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-RNO-196849.1 Metabolism of water-soluble vitamins and cofactors Mtr Mmachc Slc22a13 Nfs1 Naxd Nmnat3 Nmnat2 Qprt Mthfd1 Abcc1 Mthfd2 Folr2 Gphn Pank4 Mocos Gsto2 Shmt2 Cyb5a Lrp2 Slc25a19 Thtpa Tpk1 Slc19a2 Slc19a3 Nampt Shmt1 Ldlrap1 Pdxk Naxe Slc52a2 Slc52a3 Lrpl1 Mccc1 Btd Mccc2 Acacb Slc25a51 Acaca Aasdhppt Dhfr Fasn Slc19a1 Slc25a42 Slc5a6 Slc5a8 Bst1 Vnn1 Cblif Tcn2 Fpgs Mmut Mthfs Cubn Mthfr Slc25a32 Slc46a1 Pank3 Slc23a1 Pank2 Mthfd1l Pank1 Slc23a2 Ppcs Naprt Dcakd Mmadhc Ppcdc Pcca Coasy Rfk Pccb Acp5 Aox1 Slc2a1 Slc2a3 Nadk2 Nudt12 Mthfd2l Amn Nmrk1 Mocs3 Slc25a16 Pc Hlcs Aldh1l1 Aldh1l2 Cd38 Nadsyn1 Pnpo Nadk Cyb5r3 Nmnat1 Mmaa Mtrr Flad1 Gsto1 Mmab Nt5e Rnls Enpp1 Mocs1 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%10224073 Prolactin receptor signaling Prlr Sh2b1 Jak2 Cul1 Btrc Skp1 Rbx1 Ghr Gh1 Prl ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224711 Anchoring of the basal body to the plasma membrane Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Cc2d2a Tmem67 C2cd3 Rab8a Mark4 Cep162 Rpgrip1l Septin2 Kif24 Ttbk2 Tctn3 Fbf1 Tctn1 Akap9 Tctn2 Iqcb1 B9d1 Cep89 Mks1 Ahi1 Nphp4 Cep83 Nphp1 Ofd1 Sclt1 Tmem216 Prkar2b Ppp2r1a Hsp90aa1 Rab11a Pafah1b1 Cep97 Dync1h1 Csnk1d Ccp110 Dync1i2 B9d2 Nde1 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Clasp1 Tubg1 Ywhae Cep63 Cep152 Tuba4a Plk1 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Cdk1 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 Rab3ip SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 96%10224495 SUMO is proteolytically processed Sumo3 Senp1 Senp5 Senp5l1 Sumo2 Senp2 Sumo1 ANTIMICROBIAL PEPTIDES%REACTOME%R-RNO-6803157.1 Antimicrobial peptides Try10 Prss2l1 Pla2g2a Try5 LOC102554637 Clu Prss2 Prss3 Elane Prss1 Atp7a Defb41 Ccr6 Defb42 Np4 Defb43 Defb44 Defa24 Svs3b Ear1 Bpifb1 Bpifb6 Bpifb4 Defal1 Pglyrp1 Pglyrp2 Reg3a Reg3b Pglyrp3 Pglyrp4 Defa31 Stath Reg3g Bpi Defa Camp Bpifb2 Chga Ltf Lyz1 Tlr1 Bpifa1 Bpifa2 Defb14 Defb17 S100a9 Defb18 Art1 S100a8 Tlr2 Defb21 Defb5 Rnase6 Defb24 Defb1 Slc11a1 Defb25 Eppin Defb28 Defa9 Cd4 Defa8 Defb30 Defa6 Defa3 Itln1 Lcn2 Atox1 Ctsg Prtn3 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223955 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Chrnb4 Chrna4 Chrnb2 Chrnd Chrne Chrna3 Chrng GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 96%10222003 Gluconeogenesis Aldoa Pgk2 Pck1 Pck2 Gpi G6pc1 Eno3 Eno2 Eno4 G6pc3 Pgk1 Tpi1l2 Pc Pgam2 Pgam1 Slc37a4 Tpi1 Slc37a2 Slc37a1 Fbp1 Fbp2 Aldob Gapdhs Aldoc ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-RNO-1169091.1 Activation of NF-kappaB in B cells Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Ikbkb Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ikbkg Psmb1 Psmb3 Psmb2 Uba52 Nfkb1 Fbxw11 Btrc Psma7 Rela Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Malt1 Ubc Bcl10 Nfkbie Psmb6l1 Rel Psmd7 Nfkbib Psmd6 Psmd8 Psmd2 Prkcb Psmd1 Adrm1 Cul1 Nfkbia Chuk G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10221993 G2 M DNA damage checkpoint Ywhag Rnf8 Rhno1 Nsd2 Rad50 Babam1 Babam2 Topbp1 Rbbp8 Brca1 Hist1h2bq Uimc1 Rad1 Ccna1 Ccna2 Hist3h2ba Blm Wrn Sfn H2bc4 Hist1h4m H2bc1 Dna2 Ccnb1 Pias4 Ube2n Mre11 Kat5 Nbn Hus1 Atrip Chek1 Chek2 Ube2v2 Rad9a Rpa1 Rad9b Rpa2 Bard1 Wee1 Top3a Rpa3 Tp53 Rad17 Ywhae Rfc5 Rfc3 Rfc4 Cdc25c Rfc2 Atm Atr Cdk1 Tp53bp1 Exo1 Rmi2 Rmi1 Ywhaq Brip1 Ywhah Brcc3 ENSRNOG00000066901 Ywhab Herc2 Rnf168 Ywhaz ABRAXAS1 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%10223025 SHC1 events in EGFR signaling Egfr Shc1 Ereg Hbegf Btc Nras Grb2 Egf Kras Sos1 Hras Tgfa Areg PEPTIDE HORMONE METABOLISM%REACTOME%R-RNO-2980736.1 Peptide hormone metabolism Exoc3 Cpb2 Cpa3 Exoc4 Exoc5 Exoc6 Ins2 Exoc1 Exoc2 Exoc7 Exoc8 Gh1 Fshb Pomc Tshb Spcs3 Dpp4 Spcs1 Spcs2 Gpr119 Ffar1 P4hb Lhb Cga Grp Igf1 Bche Ero1b Mboat4 Ffar4 Ghrl Inha Pla2g7 Slc30a5 Slc30a8 Pcsk1 Gcg Lep Inhba Sec11c Gip Inhbb Inhbc Sec11a Inhbe Atp6ap2 Ctsd Ace Mme Ctsg Gzmf Agt Ren1 Ace2 Enpep Ctsz Cma1 Ces1d Ins1 Cpb1 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 96%10224507 SUMO E3 ligases SUMOylate target proteins Nup133 Nup210 Suz12 Nup155 Nup153 Mrtfa Sumo2 Ctbp1 Blm Nop58 Ikbkg Pias4 Ube2i Nfkb2 Rela Hdac2 Parp1 Hdac4 Pcna Xrcc4 Nfkbia Ikbke Tp53bp1 Nr1i2 Smc6 Smc5 Smc3 Pias3 Ddx17 Sp140 Pias1 Pias2 Ring1 Nsmce4a Casp8ap2 Hic1 Eid3 Herc2 Uhrf2 Phc2 Rnf168 Nr3c2 Sumo1 Cetn2 Nr3c1 Nsmce1 Phc1 Nsmce2 Cbx4 Sumo3 Xpc Zfp131 Sp3 Cbx2 Vdr Esr1 Stag2 Phc3 Stag1 Dnmt1 L3mbtl2 Nr1h4 Daxx Rad52 Safb Mageb10 Sp100 Ing2 Ppara Sin3a Top2b Top2a Top1 Trim28 Trim27 Pcgf2 Bmi1 Thrb Thra Brca1 Mbd1 Satb2 Satb1 Park7 Smc1a Hdac1 Nr5a1 Tfap2c Ep300 Nrip1 Rnf2 Mitf Tdg Mta1 Nr1h3 Nr1h2 Hist1h4m Rxra Pml Vhl Pgr Cdca8 Incenp Aurkb Rpa1 Nup93 Nup50 Nup35 Rara Nup54 Nup98 Npm1 Nup58 Rangap1 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Hnrnpc Nup85 Nup42 Hnrnpk Nr5a2 Nup62 Nup43 Nup88 Birc5 Ar Aaas Ranbp2 Nup214 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 96%10223257 Signalling to ERK5 Mapk7 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 96%10222887 TICAM1-dependent activation of IRF3 IRF7 Irf3 Irf7 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME%R-RNO-400206.1 Regulation of lipid metabolism by PPARalpha Fabp1 Ncoa2 Tbl1x Crebbp Ncor2 Carm1 Tgs1 Ppara Sin3a Sin3b Smarcd3 Med1 Hdac3 Tbl1xr1 Rxra REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-RNO-8943724.1 Regulation of PTEN gene transcription Phc1 Suz12 Cbx4 Eed Cbx2 Phc3 Rbbp4 Rbbp7 Bmi1 Hdac1 Maf1 Lamtor3 Mecom Lamtor2 Sall4 Hdac2 Rptor RragB Mtor Rheb Rnf2 Slc38a9 Chd3 Lamtor5 Chd4 Lamtor4 Rraga Lamtor1 Mta1 Rragc Ring1 Mta2 Rragd Mta3 Mbd3 Mlst8 Ezh2 Phc2 Cbx6 Gatad2a Gatad2b GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223637 Glyoxylate metabolism and glycine degradation Grhpr Hao1 Aldh4a1 Got2 Amt Gnmt Gcsh Dao Agxt2 Ddo Prodh2 Dld Agxt AC132020.1 Ogdh Dlst Kgd4 NUCLEAR RNA DECAY%REACTOME%R-RNO-9930044.1 Nuclear RNA decay Ncbp2 Ncbp1 Dis3 Zcchc8 Zfc3h1 Papolg Srrt Mphosph6 Rbm26 Rbm27 Zc3h18 Exosc10 Rbm7 C1d Zc3h4 Zc3h3 Exosc9 Exosc8 Exosc5 Exosc4 Ythdc2 Exosc7 Ythdc1 Exosc6 Exosc1 Exosc3 Exosc2 Pabpn1 Wdr82 SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 96%10223031 Signaling by FGFR2 Ppp2cb Ppp2ca Hnrnph1 Frs2 Plcg1 Frs3 Fgfr2 Fgf16 Fgfbp3 Fgf17 Fgfbp1 Pik3ca Fgf18 Shc1 Braf Rbfox2 Ppp2r1a Esrp2 Fgf10 Esrp1 Mapk3 Tial1 Tia1 Pik3r1 Src Spry2 Mknk1 Nras Rps27a Grb2 Kras Sos1 Polr2c Hras Polr2a Ptpn11 Polr2b Fgf20 Polr2g Fgf23 Polr2h Polr2e Fgf22 Polr2f Polr2i Gab1 Polr2j Ncbp2 Ncbp1 Uba52 Gtf2f2 Hnrnpa1 Gtf2f1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Ubb Fgf8 Fgf7 Ubc Fgf9 Ptbp1 Cbl Mapk1 Hnrnpf ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%10225269 Activated NTRK3 signals through PI3K Src Ntrk3 Ntf3 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9034793.1 Activated NTRK3 signals through PLCG1 Plcg1 Ntrk3 Ntf3 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%10222989 Sulfur amino acid metabolism Mtr Slc25a10 Cbs Cth Mpst Usf1 Sqor Ethe1 Fmo1 Mri1 Suox Ado Txn2 Bhmt Ahcy Mtap Enoph1 Mtrr Tst Adi1 Bhmt2 Gadl1 Mat1a Cdo1 ERBB2 REGULATES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%10224873 ERBB2 Regulates Cell Motility Diaph1 Memo1 Egfr Erbb2 Egf Erbb3 Ereg Nrg2 Nrg3 Hbegf Btc Rhoa BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 96%10222337 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Hadha Hadhb Acadl Echs1 Hadh G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-RNO-69615.1 G1 S DNA Damage Checkpoints Zfp385a Gsk3b Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Psmd13 Cdc25a Skp1 Psmb5 Plk3 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Phf20 Uba52 Fbxw11 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Chek1 Psmc3 Chek2 Ubb Ubc Tp53 Psmb6l1 Cdkn1b Psmd7 Psmd6 Psmd8 Mapk14 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Atm Cop1 Mdm4 Mapk11 Csnk1e INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME%R-RNO-9006925.1 Intracellular signaling by second messengers Suz12 Erbb2 Eed Erbb3 Ereg Pdpk1 Frs2 Rbbp4 Btc Rbbp7 Tnks2 Pdgfa Pdgfb Xiap Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Creb1 Fgf17 Fgf18 Fgf19 Fgf10 Hbegf Mapk3 Ntrk3 Ntf3 Stub1 Rnf146 Grb2 Fyn Tnks Tgfa Fgf20 Wwp2 Fgf23 Areg Fgf22 Kit Traf6 Ppp2r5b Ppp2r5a Pip5k1b Kitlg Ppp2r5e Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Lamtor3 Lamtor2 Hgf Egfr Hdac2 Irak1 Pdgfrb Pdgfra Chuk Kl Flt3 Nrg2 Nrg3 Met Prex2 Egf Trib3 Them4 Insr Rac1 Psma4 Akt3 Psma3 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Chd3 Cd19 Rps27a Chd4 Psmd12 Psmd11 Tsc2 Psmd14 Psmd13 Mta1 Mta2 Mta3 Mbd3 Psmb5 Gatad2a Psmb4 Gatad2b Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Strn Psmc5 Psmc2 Psmc1 Psmc4 Esr2 Psmc3 Ubb Ubc Foxo3 Psmb6l1 Prkce Cdkn1b Psmd7 Rptor Psmd6 RragB Psmd8 Psmd2 Psmd1 Mtor Adrm1 Rheb Slc38a9 Mapk1 Lamtor5 Akt1s1 Lamtor4 Rraga Lamtor1 Rragc Pik3r6 Rragd Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Mlst8 Adcy7 Camkk2 Ins1 Adcy8 Adcy5 Adcy6 Ppp2cb Ins2 Ppp2ca Foxo4 Adcy9 Nedd4 Prkaca Prkacb Prkcg Prkcd Prkca Il33 Camk4 Prkar1a Prkar1b Calm3 Ppp2r5d Grk2 Usp7 Il1rap Irak4 Mkrn1 Prkar2a Prkar2b Ppp2r1b Ppp2r1a Pde1b Pde1c Src Pde1a Otud3 Pten Usp13 Lck Rhog Rac2 Ring1 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Esr1 Phc3 Csnk2a2 Trim27 Csnk2a1 Bmi1 Hdac1 Maf1 Mecom Sall4 Csnk2b Pik3ca Gab2 Pip5k1c Pik3r1 Pik3cb Rnf2 Pik3r2 Pik3r3 Vav1 Pik3cd Ptpn11 Gab1 Pml Pik3r5 Pik3cg Ier3 Irs2 Phlpp1 Pip4k2b Pip4k2c Pip4k2a Rps6kb2 Pik3ap1 Foxo6 Cd28 Icos Sgk1 Nr4a1 Ntf4 Pip5k1a Frk Rictor Cd86 Cd80 Prr5 Bdnf Il1rl1 Trat1 Casp9 Myd88 Mapkap1 Ntrk2 Foxo1 Ezh2 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10222569 Integrin cell surface interactions Jam2 F11r Fgb Fga Fgg Itga2b Col13a1 Itgb8 Itgb6 Spp1 Cd44 Itgb1 Fn1 Itga3 Itga4 Pecam1 Itgb3 Fbn1 Col4a1 Col4a2 Itga1 Itgal Itgb2 Cdh1 Tnc Thbs1 Madcam1 Itgax Comp Itgae Itgad Itga9 Itgb7 Icam1 Icam5 Icam4 Icam2 Itga2 Itga10 Col4a4 Vcam1 Ibsp Col18a1 Cd47 Bsg Itga6 Itga8 Itgav Vtn Jam3 Lum VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-RNO-964975.1 Vitamin B6 activation to pyridoxal phosphate Pdxk Pnpo Aox1 MALATE-ASPARTATE SHUTTLE%REACTOME%R-RNO-9856872.1 Malate-aspartate shuttle Slc25a22 Got2 Got1 Mdh1 Mdh2 Slc25a11 Slc25a12 Slc25a13 Slc25a18 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-RNO-418597.1 G alpha (z) signalling events Adcy5 Adcy6 Adra2b Adcy9 Adra2a Adra2c Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Gnb2 Gnb1 Rgs20 Rgs17 Gnb4 Rgs16 Gnb3 Gnaz Gnb5 Gng11 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 96%10224727 RHO GTPases activate KTN1 Klc1 Klc4 Kif5a Rhog Rac1 Kif5b Ktn1 Klc3 Klc2 Cdc42 Rhoa ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 96%10223841 Zinc efflux and compartmentalization by the SLC30 family Slc30a1 Slc30a5 Slc30a8 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-RNO-176409.1 APC C:Cdc20 mediated degradation of mitotic proteins Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 Cdk1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-RNO-1793185.1 Chondroitin sulfate dermatan sulfate metabolism Chst3 Dsel Ust Dse Cspg5 Bgn Cspg4 Chst14 Chst15 Idua Hyal4 Hyal3 Ids Hyal1 Gusb Glb1 Arsb Bcan Vcan Ncan Dcn Glb1l Chst11 Chst12 Chsy1 Chsy3 Chst13 Chpf Glb1l3 Glb1l2 Csgalnact2 Chst7 Chst9 Hexa Hexb DUAL INCISION IN GG-NER%REACTOME%R-RNO-5696400.1 Dual Incision in GG-NER Chd1l Ddb2 Gtf2h2 Gtf2h1 Uba52 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Ercc1 Ercc4 Pole3 Pole2 Pole4 Rpa1 Rpa2 Polk Ubb Rpa3 Ubc Pole Parp2 Parp1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Rfc2 Pold4 Pold3 Rps27a Xpa Ddb1 Cul4a Cul4b O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%10224019 O-linked glycosylation Qtgal Adamts1 Adamts3 Adamts2 Adamts9 Adamts8 Adamts7 Adamts6 Pofut2 Thsd1 Thbs2 Pofut3 Pofut4 Thsd4 Cfp Spon2 Spon1 Sspo B3glct B3gnt9 B3gnt8 B3gnt6 B3gnt5 Galnt1 Galnt2 Galnt5 Galnt7 Galnt6 Galnt10 Galnt17 Galnt18 Galnt15 Galnt16 Galnt13 Galnt14 Galnt11 Galnt12 Gcnt7 Gcnt4 Gcnt3 Chst4 Sema5a Sema5b Gcnt1 C1galt1 C1galt1c1 Galntl6 Mmrn2 Galntl5 Adamts13 Adamts14 Adamts15 Adamts16 Adamts17 Adamts18 Muc15 Adamts19 Muc13 Adamts10 Muc19 Sbspon A4gnt Muc5b Adamts12 Muc4 Muc6 Thsd7a Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Galnt9 Adamts20 Thsd7b Thbs1 Mgat5b B3galnt2 Pomk Pomgnt2 B3gnt7 B3gnt2 B4galt5 B4galt6 Adamts5 B4gat1 Adamts4 Pomt1 Pomt2 Chst10 Fkrp Slc35a4 Rxylt1 Crppa Dag1 Large1 Large2 Fktn Pomgnt1 Mmrn1 St6galnac3 St6galnac2 St3gal4 St3gal2 St3gal3 Slc35a1 St3gal1 St6gal1 B3gnt3 Galnt3 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 96%10224371 RHO GTPases Activate WASPs and WAVEs Nckipsd Arpc3 Nck1 Arpc2 Actb Arpc5 Arpc4 Brk1 Actg1 Nckap1l Wipf3 Wipf1 Wasf3 Wasf2 Wasf1 Rac1 Baiap2 Ptk2 Mapk3 Arpc1b Actr2 Arpc1a Mapk1 Actr3 Grb2 Btk Abl1 Cdc42 Nckap1 Abi2 Abi1 Cyfip2 Cyfip1 TIGHT JUNCTION INTERACTIONS%REACTOME%R-RNO-420029.1 Tight junction interactions F11r Pard6g Prkci Pard6b Pard6a Pard3 SIGNALING BY FGFR1%REACTOME%R-RNO-5654736.1 Signaling by FGFR1 Ppp2cb Ppp2ca Frs2 Spred1 Plcg1 Frs3 Spred2 Fgfrl1 Fgfr1 Fgf17 Pik3ca Fgf18 Shc1 Braf Ppp2r1a Fgf10 Mapk3 Pik3r1 Src Spry2 Mknk1 Nras Rps27a Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Fgf22 Gab1 Tgfbr3 Uba52 Gipc1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Ubb Fgf8 Flrt1 Ubc Flrt3 Fgf9 Flrt2 Cbl Mapk1 Kl INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223905 Interleukin-7 signaling Irs2 Stat3 Brwd1 Tslp Il7 Smarca4 Il7r Pik3r1 Jak3 Pik3r2 Pik3r3 Irs1 H2bc18 Stat5a Stat5b TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-RNO-174362.1 Transport and metabolism of PAPS Slc26a11 Slc26a2 Slc26a1 Slc35b3 Slc35b2 Papss2 Papss1 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-RNO-5357786.1 TNFR1-induced proapoptotic signaling Tbk1 Traf2 Sharpin Tnf Otud1 Ikbke Tnfrsf1a Tradd Mib2 Birc2 Cyld Spata2 Rnf31 Ripk1 Otud7b Fadd Rbck1 Usp2 Xiap Usp4 Usp21 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-RNO-432040.1 Vasopressin regulates renal water homeostasis via Aquaporins Prkaca Prkacb Avp Myo5b Aqp1 Aqp4 Prkar1a Aqp3 Aqp2 Prkar1b Gng3 Gng5 Gng4 Gng7 Avpr2 Gng8 Gngt1 Prkar2a Prkar2b Gnb2 Gnb1 Gnb4 Gnb3 Rab11a Gnb5 Gng11 Gng10-ps1 Gnas IRS ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222217 IRS activation Irs2 Ins2 Insr Irs1 Grb10 Ins1 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-RNO-9818027.1 NFE2L2 regulating anti-oxidant detoxification enzymes Srxn1 Prdx1 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-RNO-9025094.1 Biosynthesis of DPAn-3 SPMs Alox12 Ptgs2 Alox5 Alox15 CO-INHIBITION BY BTLA%REACTOME%R-RNO-9927353.1 Co-inhibition by BTLA Grb2 Btla Ptpn11 Ptpn6 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-RNO-2454202.1 Fc epsilon receptor (FCERI) signaling Pdpk1 ENSRNOG00000070986 Lat2 Prkcq Cdc34 Calm3 Ube2d2 Pak1 Pak2 Mapk3 Lyn Nras Grb2 Kras Sos1 Hras Mapk9 Ikbkb Lcp2 Mapk8 Traf6 Ikbkg Map3k7 Ube2n Nfkb1 Fbxw11 Fos Rela Map3k1 Fcer1a Txk Ppp3ca Ppp3cb Itk Map2k7 Nfatc1 Nfatc3 Malt1 Nfatc2 Bcl10 Ppp3r1 Grap2 Ms4a2 Tec Jun Nfkbia Btk Tab3 Tab2 Tab1 Chuk Lat Mapk10 Fcer1g Plcg1 Pik3ca Shc1 Rac1 Psma4 Gab2 Psma3 Psma6 Pik3r1 Pik3cb Psma5 Psma2 Psma1 Rps27a Vav3 Pik3r2 Psmd12 Psmd11 Vav1 Vav2 Psmd14 Psmd13 ENSRNOG00000069193 AABR07065813.1 Skp1 ENSRNOG00000062915 Igll1 Psmb5 ENSRNOG00000065191 Psmb4 Ighl12 Psmb7 ENSRNOG00000062682 Psmb6 ENSRNOG00000070812 ENSRNOG00000070415 Psmb1 ENSRNOG00000070810 Psmb3 ENSRNOG00000066926 Psmb2 ENSRNOG00000066406 Uba52 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Ube2d1 Syk Btrc Iglc1 ENSRNOG00000070159 Psma7 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 Psmc5 Psmc2 ENSRNOG00000066971 Psmc1 ENSRNOG00000063341 Psmc4 ENSRNOG00000065283 Psmc3 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Plcg2 Ubb ENSRNOG00000067679 ENSRNOG00000070832 Ubc ENSRNOG00000064041 ENSRNOG00000064481 Psmb6l1 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 Psmd7 ENSRNOG00000063713 ENSRNOG00000062820 Psmd6 ENSRNOG00000064886 Psmd8 ENSRNOG00000064490 ENSRNOG00000066072 Psmd2 AABR07065781.1 ENSRNOG00000069901 Psmd1 ENSRNOG00000067603 Adrm1 Cul1 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Mapk1 ABACAVIR ADME%REACTOME%R-RNO-2161522.1 Abacavir ADME Slc22a3 Slc22a2 Slc22a1 Adh1 Nt5c2 INTERLEUKIN-37 SIGNALING%REACTOME%R-RNO-9008059.1 Interleukin-37 signaling Stat3 Tbk1 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-RNO-2995410.1 Nuclear Envelope (NE) Reassembly Nup133 Nup155 Ppp2ca Tubb4b Tubb4a Ppp2r1a Emd Lmnb1 Ccnb2-ps2 Tuba1b Chmp2a Ccnb1 Ppp2r2a Ube2i Vrk2 Nup93 Tuba1a Nup35 Kpnb1 Nup98 Tuba1c Tubal3 Rangap1 Nup37 Rcc1 Pom121 Chmp2b Tuba4a Cc2d1b Nup205 Spast Tubb2b Nup107 Tubb2a Sec13 Ist1 Chmp3 Nup188 Vrk1 Chmp7 Cdk1 Nup160 Chmp6 Lmna Ahctf1 Vps4a Ndc1 Sirt2 Tuba8 Chmp4c Nup85 Tuba3b Chmp4bl1 Lbr Tubb6 Nup43 Tubb3 Tubb1 Banf1 Ran Ccnb2 Ankle2 Sumo1 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%10222583 Platelet calcium homeostasis Slc8a1 Slc8a2 Slc8a3 Itpr3 Itpr2 P2rx7 Itpr1 Atp2a1 Atp2a3 P2rx6 Atp2a2 P2rx5 P2rx4 P2rx3 Trpc7 P2rx2 P2rx1 Trpc3 Atp2b1 Atp2b4 Atp2b3 Calm3 Sri PEXOPHAGY%REACTOME%R-RNO-9664873.1 Pexophagy Pex5 Rps27a Usp30 Map1lc3b Uba52 Ubb Sqstm1 Nbr1 Atm Ubc SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 96%10224407 Synthesis of 12-eicosatetraenoic acid derivatives Alox12b Alox12 Gpx4 Alox15 Gpx2 Aloxe3 Gpx1 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME%R-RNO-9958825.1 Activation of STAT3 by cadherin engagement Arhgef4 Hace1 Uba52 Stat3 Nfkb1 Ctnnb1 Ctsb Birc2 Cbll1 Rela Ctss Cdh1 Ctnna1 Ctsl Jup Ctnnd1 Xiap Ubb Ubc Cdh11 Jak2 Vcl Tiam1 Rac1 Farp2 Il6 Src Il6r Rps27a Vav2 Tyk2 Cdc42 Il6st Rnf19b NADE MODULATES DEATH SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223185 NADE modulates death signalling Ywhae Casp3 Casp2 Ngfr Ngf Bex3 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-RNO-9913635.1 Strand-asynchronous mitochondrial DNA replication Polrmt Polg2 Twnk Ssbp1 Polg NUCLEAR SIGNALING BY ERBB4%REACTOME%R-RNO-1251985.1 Nuclear signaling by ERBB4 Wwox Aph1b Esr1 Psenen Psen1 Psen2 Yap1 Stat5a Ncstn Src Aph1a CYP2E1 REACTIONS%REACTOME%R-RNO-211999.1 CYP2E1 reactions Cyp2f2 Cyp2s1 Cyp2d4 Cyp2a2 Cyp2a1 Cyp2a3 Cyp2c66 Cyp2e1 Cyp2c11 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-RNO-174143.1 APC C-mediated degradation of cell cycle proteins Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Aurka Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Cdc14a Psmd7 Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%10223441 HDL assembly Bmp1 Abca1 Zdhhc8 Prkaca Prkacb A2m Apoa1 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-RNO-9933939.1 Formation of the polybromo-BAF (pBAF) complex Smarcc1 Phf10 Smarca2 Smarca4 Actl6a Smarcd1 Smarce1 Smarcd3 Smarcd2 Pbrm1 Brd7 Actg1 Bcl7a Smarcb1 Bcl7b Bcl7c PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-RNO-76009.1 Platelet Aggregation (Plug Formation) Apbb1ip Fgb Fga Adra2b Fgg Pdpk1 Itga2b Adra2a Syk Adra2c Rasgrp1 Csk Tln1 Fn1 Itgb3 Bcar1 Shc1 Ptpn1 Rapgef4 Rapgef3 Rasgrp2 Ptk2 Akt1 Src Grb2 Rap1a Rap1b Sos1 Crk SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 96%10223045 Signaling by FGFR4 Ppp2cb Ppp2ca Uba52 Frs2 Plcg1 Frs3 Klb Fgf2 Fgf1 Fgf4 Fgf6 Ubb Fgf8 Ubc Fgfr4 Fgf9 Fgf16 Fgf17 Pik3ca Shc1 Fgf18 Fgf19 Braf Ppp2r1a Mapk3 Src Spry2 Pik3r1 Mknk1 Cbl Nras Mapk1 Rps27a Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Gab1 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 96%10223299 ERKs are inactivated Dusp7 Dusp6 Ppp2cb Ppp2ca Ppp2r1b Ppp2r1a Mapk3 Vrk3 Mapk1 Ppp2r5d Mapk7 Dusp3 Dusp4 INOSITOL PHOSPHATE METABOLISM%REACTOME%R-RNO-1483249.1 Inositol phosphate metabolism Nup133 Nup210 Nup155 Nup153 Miox Ip6k3 Isyna1 Itpka Itpkc Itpkb Plcg1 Impa2 Impa1 Inpp5a Inpp5b Plch1 Pld4 Plcd1 Plcd4 Ocrl Inpp5j Plcd3 Nudt4 Calm3 Nudt3 Synj1 Plcz1 Plce1 Inpp1 Ppip5k1 Ppip5k2 Inpp5d Inppl1 Ippk Ipmk Ip6k1 Ip6k2 Inpp4a Inpp4b Itpk1 Pten Minpp1 Nup93 Nup50 Plcg2 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Plcb4 Nup160 Plcb3 Rae1 Ndc1 Plcb2 Plcb1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222905 GABA receptor activation Adcy5 Adcy6 Adcy9 Gabrr1 Gabrr3 Gnai2 Gabrr2 Gnai1 Gabrq Gnai3 Gabrb1 Gabrb3 Gabrb2 Gng3 Gnal Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Gnat3 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Arhgef9 Gabrg2 Gabrg3 Gng10-ps1 Adcy3 Gabra4 Adcy4 Gabra3 Adcy1 Gabra6 Adcy2 Gabra5 Gabra2 Adcy7 Gabra1 Adcy8 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 96%10223619 Receptor-type tyrosine-protein phosphatases Il1rap Slitrk5 Slitrk6 Slitrk3 Slitrk4 Slitrk1 Slitrk2 Ppfibp2 Ppfibp1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Ptprs Ntrk3 Lrrc4b Il1rapl1 Il1rapl2 Ptprf ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-RNO-68616.1 Assembly of the ORC complex at the origin of replication Hist1h2ai H2aj H2ab2 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Orc4 H2bc18 Orc6 Orc1 H2az2 Hist1h2bq Orc3 ENSRNOG00000066901 Orc2 H2bc4 Hist1h4m Kpnb1 H2bc1 Kpna6 Kpna1 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME%R-RNO-499943.1 Interconversion of nucleotide di- and triphosphates Txn Rrm2b Txnrd1 Dtymk Nudt13 Dut Rrm1 Tyms Rrm2 Ak1 Gsr Nme3 Ak2 Nme2 Ak5 Glrx Ak4 Ak7 Ak6 Ak9 Nme1 Cmpk1 Dctd Ak8 Nme6 Ctps2 Ctps1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 96%10223641 Beta-oxidation of pristanoyl-CoA Acoxl Crat Acox2 Amacr Acox3 Acot8 Crot Hsd17b4 Scp2 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10222277 SLC-mediated transmembrane transport Slco2b1 Slco2a1 Slco4c1 SLC16A2 Slco1c1 Slc15a1 Ctns Slc15a3 Slc15a4 Slc1a5 Slc26a2 Slc26a1 Slc35b3 Slc35b2 Slc26a11 Slc22a3 Arl2 Slc4a7 Slc35d2 Bsg Slc13a4 Slc13a1 Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc67a1 Slc44a2 Slc4a2 Slc4a4 Slc4a3 Avp Slc4a5 Slc4a8 Slc33a1 Slc4a9 Slc10a6 Slc22a8 Slc22a7 Slc45a3 Slc5a6 Slc12a1 Slc35d1 Slc5a8 Slc12a4 Slc22a6 Slc12a5 Lcn12 Slc12a2 Slc22a5 Slc12a3 Slc22a4 Slc12a6 Slc5a1 Slc12a7 Slc5a3 Slc34a3 Slc5a2 Slc5a4 Slc5a7 Slc35c1 Slc11a2 Apod Slc27a1 Arl2bp Slc25a26 Slc25a29 Slc39a4 Slc39a3 Slc39a2 Slc39a1 Emb Slc39a8 Slc2a1 Slc39a7 Slc2a3 Slc39a6 Slc16a7 Slc2a13 Slc6a6 Slc2a12 Slc16a3 Slc2a10 Slc16a8 Slc31a1 Fgf21 Slc16a1 Slc28a3 Slc28a2 Slc28a1 Slc20a2 Slc20a1 Slc43a1 Slc43a2 Slc17a1 Slc7a3 Slc7a1 Mfsd4b4 Slc29a3 Slc29a2 Slc29a1 Slc29a4 Slc30a10 Slc25a1 Slc40a1 Slc14a2 Slc14a1 Slc26a6 Slc26a4 Slc26a3 Slc26a9 Slc8b1 Slc26a7 Slc41a2 Lcn9 Slc41a1 Slc1a1 Slc38a5 Slc38a4 Slc38a3 Slc1a4 Slc38a2 Slc1a7 Calm3 Slc1a6 Slc9a1 Slc9a4 Slc9a5 Slc9a2 Slc9a3 Slc9a8 Slc6a12 Slc9a9 Slc9a6 Slc9a7 Slc27a4 Slc27a6 Slc35b4 Slc5a10 Slc5a12 Slc5a11 Slc2a2 Slc2a4 Slc2a8 Slc2a7 Slc2a9 Slc35a3 Slc35a2 Slc39a14 Slc50a1 Slc24a5 Slc47a1 Slc24a4 Slc24a3 Slc22a2 Slc24a2 Slc6a19 Slc24a1 Slc6a5 Ahcyl2 Slc22a1 Slc22a15 Slc32a1 Vegp2 Slc6a7 Vegp1 Slc6a15 Slc22a12 Slc6a9 Slc22a16 Slc6a14 Slc3a1 Slc6a11 Slc13a5 Slc6a13 Sri Slc36a4 Slc6a20 Slc13a3 Slc25a18 Slc36a2 Slc25a22 Slc36a1 Slc6a2 Slc3a2 Slc13a2 Slc17a7 Slc4a10 Slc6a1 Slc16a10 Slc17a8 Heph Slc6a4 Slc25a5 Slc6a3 Slc25a4 Slc17a6 Slc34a1 Slc34a2 Slc4a1 Slc11a1 Slc30a5 Slc30a8 Slc7a11 Slc7a10 Slc7a6 Slc7a7 Slc7a5 Slc7a8 Slc7a9 Slc8a1 Slc8a2 Slc8a3 Slc5a5 Runx1 Cp Slc25a10 Slc17a5 Slc35a1 Slc38a1 Slc1a3 Slc1a2 Slc25a11 Slc30a1 Slco3a1 Slco1a4 Slco4a1 Slco1b2 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-RNO-5607763.1 CLEC7A (Dectin-1) induces NFAT activation Calm3 Ppp3ca Ppp3cb Nfatc1 Nfatc3 Nfatc2 Ppp3r1 ION HOMEOSTASIS%REACTOME%R-RNO-5578775.1 Ion homeostasis Slc8a1 Slc8a2 Atp1b1 Slc8a3 Atp1b3 Atp1b2 Ryr2 Ryr1 Prkaca Fkbp1b Dmpk Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Clic2 Calm3 Trdn Ahcyl1 Pln Asph Trpc1 Nos1 Stim1 Tnni3 Itpr3 Itpr2 Itpr1 Atp2a1 Atp2a3 Atp2a2 Kcnj11 Abcc9 Camk2g Atp2b1 Camk2d Atp2b4 Atp2b3 Camk2b Sri Camk2a MAPK3 (ERK1) ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222397 MAPK3 (ERK1) activation Map2k1 Jak2 Tyk2 Ptpn11 Il6 Mapk3 Il6st Cdk1 Il6r BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 96%10222351 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Acadm Hadha Hadhb Echs1 Hadh Mecr MACROAUTOPHAGY%REACTOME%R-RNO-1632852.1 Macroautophagy Map1lc3b Prkab2 Prkab1 Ube2d3 Ube2d2 Atg7 Tomm20 Src Prkn Usp30 Ube2l3 Pex5 Ube2n Atg3 Lamtor3 Mtmr14 Lamtor2 Rb1cc1 Uvrag Atg10 Atg13 Atg14 Tomm22 Chmp2b Atg5 Tbk1 Atg12 Gabarapl1 Mtmr3 Atg9a Pcnt Atg9b Atm Atg101 Chmp3 Pgam5 Tomm40 Chmp7 Ambra1 Chmp6 Wdr45b Wdr45 Arl13b Atg16l2 Mterf3 Atg16l1 Chmp4c Map1lc3a Pink1 Chmp4bl1 Fundc1 Tomm7 Wipi2 Wipi1 Atg4b Atg4c Nbr1 Atg4a Atg4d Csnk2a2 Csnk2a1 Park7 Csnk2b Sqstm1 Optn Rps27a Tsc2 Tsc1 Ulk1 Pik3c3 Chmp2a Gabarap Dync1h1 Uba52 Pik3r4 Dync1i2 Dync1i1 Gabarapl2 Ubb Ubc Mfn1 Mfn2 Rptor RragB Prkaa1 Prkaa2 Mtor Vdac2 Vdac3 Rheb Vdac1 Dync1li2 Becn1 Dync1li1 Tomm70 Slc38a9 Lamtor5 Dynll1 Lamtor4 Prkag3 Dynll2 Rraga Prkag1 Prkag2 Lamtor1 Rragc Rragd Mlst8 Cftr SODIUM PROTON EXCHANGERS%REACTOME DATABASE ID RELEASE 96%10223771 Sodium Proton exchangers Slc9a1 Slc9a4 Slc9a5 Slc9a2 Slc9a3 Slc9a8 Slc9a9 Slc9a6 Slc9a7 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%R-RNO-1168372.1 Downstream signaling events of B Cell Receptor (BCR) Rasgrp1 Calm3 Psma4 Psma3 Psma6 Psma5 Psma2 Nras Psma1 Rps27a Psmd12 Psmd11 Kras Psmd14 Hras Psmd13 Ikbkb Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ikbkg Psmb1 Psmb3 Psmb2 Uba52 Nfkb1 Fbxw11 Btrc Psma7 Rela Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ppp3ca Ppp3cb Nfatc1 Ubb Nfatc3 Malt1 Nfatc2 Ubc Ppp3r1 Bcl10 Nfkbie Psmb6l1 Rel Psmd7 Nfkbib Psmd6 Psmd8 Fkbp1a Psmd2 Prkcb Psmd1 Adrm1 Cul1 Nfkbia Chuk FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-RNO-196025.1 Formation of annular gap junctions Cltb Cltc Dab2 Dnm1 Dnm2 Ap2m1 Gja1 Clta TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 96%10224317 Trafficking and processing of endosomal TLR Lgmn Tlr8 Tlr9 Hsp90b1 Cnpy3 Ctsk Ctsl Tlr7 Ctsb Ctss Unc93b1 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222067 Proline catabolism Aldh4a1 Prodh Prodh2 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-2871837.1 FCERI mediated NF-kB activation Pdpk1 ENSRNOG00000070986 Prkcq Cdc34 Ube2d2 Lyn Ikbkb Traf6 Ikbkg Map3k7 Ube2n Nfkb1 Fbxw11 Rela Malt1 Bcl10 Nfkbia Tab3 Tab2 Tab1 Chuk Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 ENSRNOG00000069193 AABR07065813.1 Skp1 ENSRNOG00000062915 Igll1 Psmb5 ENSRNOG00000065191 Psmb4 Ighl12 Psmb7 ENSRNOG00000062682 Psmb6 ENSRNOG00000070812 ENSRNOG00000070415 Psmb1 ENSRNOG00000070810 Psmb3 ENSRNOG00000066926 Psmb2 ENSRNOG00000066406 Uba52 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Ube2d1 Btrc Iglc1 ENSRNOG00000070159 Psma7 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 Psmc5 Psmc2 ENSRNOG00000066971 Psmc1 ENSRNOG00000063341 Psmc4 ENSRNOG00000065283 Psmc3 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Ubb ENSRNOG00000067679 ENSRNOG00000070832 Ubc ENSRNOG00000064041 ENSRNOG00000064481 Psmb6l1 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 Psmd7 ENSRNOG00000063713 ENSRNOG00000062820 Psmd6 ENSRNOG00000064886 Psmd8 ENSRNOG00000064490 ENSRNOG00000066072 Psmd2 AABR07065781.1 ENSRNOG00000069901 Psmd1 ENSRNOG00000067603 Adrm1 Cul1 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 PHOSPHO-PLA2 PATHWAY%REACTOME%R-RNO-111995.1 phospho-PLA2 pathway Mapk1 Pla2g4a CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 96%10224121 Chromatin organization Suz12 Eed Snrpepl2 Wdr77 Ctnnb1 Rbbp4 Rbbp7 Rbm17 Ddx46 Ddx42 Cdc73 Atf2 Chd8 Leo1 Nfkb2 Brwd1 Nfkb1 Rela Hdac2 Hdac10 Hdac8 Ncoa2 Ssrp1 Rcor1 Kdm4c Chd3 Chd4 Mbd2 Mta1 Mta2 Mta3 Mbd3 Cbx3 Kdm1a Gatad2a Gatad2b Hmg20b Tbl1x Hdac3 Tbl1xr1 Ncor2 Carm1 Gps2 Suds3 Brpf3 Kdm1b Kdm5b Coprs H2ac25 Prmt7 Dnmt3a Prmt3 Rps2 Ube2i Phf5a U2surp Skic8 Suv39h1 Snrpa1 H2ab2 Arid1a Arid1b Kmt5a H2ac4 Actl6a Actl6b Kdm4b Smarce1 Kdm4a Setd1b Setd1a ENSRNOG00000066901 Sf3a1 Sf3a2 Sumo1 Sf3a3 Sf3b1 Sf3b3 Ccnd1 Padi2 Sf3b4 Padi3 Sf3b5 Padi4 Nsd2 Padi1 Kmt2d Kat7 Padi6 Ehmt1 Kdm6b Kmt2a Kdm7a Kmt2b Phf2 Kmt2c H2ac18 Phf8 Ing4 Ing5 Setdb2 Ss18 Setdb1 Dpf1 Brd1 Pax3 Bicral Dot1l Bicra Dpf2 Setd3 Dpf3 Nsd3 Pbrm1 Setd2 Brd9 Prmt6 Setd7 Brd7 Hist1h2bq Setd6 Actg1 Ss18l1 Prmt1 Nsd1 Ash1l Smarcb1 Bcl7a Riox2 Hdac1 Bcl7b Suv39h2 Wdr5 Bcl7c Bcl11a Ash2l Mecom Smyd2 Bcl11b Smyd3 Brms1 Phf10 Aebp2 H2aj Kmt5b Snrpn Hat1 Atf7ip Jade1 Cherp Jade2 Smarca2 Jade3 Smarca4 Brpf1 H3-3b Kat6b Kat6a Prdm16 Hist3h2ba Sap30l Kdm4d ENSRNOG00000068602 Meaf6 Arid5b Uty Smarcd1 Msl2 Msl3 Smarcd3 Kdm5c Msl1 Smarcd2 Kdm5a Kat8 Kdm6a H2bc18 Arid4b Arid4a Jmjd6 H2az2 Kdm2b Rbbp5 H2bc4 Rest Kmt5c Hist1h4m H2bc1 Kdm3b Kdm3a Prdm9 Smarcc1 Hist1h2ai Puf60 Phf20 Hcfc1 Sap18 Kansl3 Kansl1 Kansl2 Smndc1 Mcrs1 Snrpf Ogt Snrpg Snrpb Nr2c2 Fam124b Zmynd8 Prmt5 Ikzf3 Ikzf1 Zfp827 Zfp532 Adnp Cbx1 Ctr9 Paf1 Phf6 Zfp592 Ctcf Cdk2ap1 Snrpd1 Nr2f2 Chd1 Chd2 Chd5 Chd6 Chd7 Tcf19 Cdk4 Dhx15 Pwwp2a Ezh2 Snrpd3 Mbd3l1 Mbd3l2 Zfp687 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-RNO-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Phc1 Smarcc1 Cbx4 Cbfb Cbx2 Phc3 Csnk2a2 Csnk2a1 Bmi1 Pbrm1 Smarcb1 Yaf2 Csnk2b Smarca2 Arid1a Smarca4 Arid1b Ep300 Rnf2 Actl6a Smarcd1 Actl6b Smarce1 Smarcd3 Pcgf5 Smarcd2 Ring1 Runx1 Phc2 Cbx6 EXTENSION OF TELOMERES%REACTOME%R-RNO-180786.1 Extension of Telomeres Terf2 Acd Terf1 Terf2ip Tinf2 Pot1 Ccna1 Ccna2 Ppp6r3 Chtf8 Ppp6c Blm Wrn Chtf18 Tert Ctc1 Stn1 Ten1 Dscc1 Dna2 Shq1 Dkc1 Nhp2 Pif1 Gar1 Wrap53 Rtel1 Nop10 Rpa1 Ankrd28 Rpa2 Rpa3 Lig1 Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Cdk2 Pola1 Pold4 Pold3 Prim2 Prim1 RIBAVIRIN ADME%REACTOME%R-RNO-9755088.1 Ribavirin ADME Itpa Pnp Nme2 Slc28a3 Slc28a2 Adk Nme1 Ada Slc29a3 Slc29a1 Nt5c2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 96%10222597 Activation of BH3-only proteins Ywhag Ywhae Bcl2l11 Ppp3cc Pmaip1 Dynll1 Dynll2 Bad Bmf Ywhaq Ywhah Sfn Ywhab Ppp3r1 Mapk8 Ywhaz AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222043 Amino acid and derivative metabolism Gpt2 Mtr Kmo Acad8 Carns1 Sirt5 Naalad2 Cps1 Qdpr Hibadh Azin2 Psph Rimkla Rimklb Tat Amd1 Asns Aldh7a1 Crat Nat8l Bcat1 Bcat2 Hibch Smox Sat1 Pcbd1 Carnmt1 Bckdhb Dct Pipox Bckdha Crym Gls2 Psat1 Srm Il4i1 Srr Aspg Hao1 Nags Aspa Bckdk Tmlhe Uroc1 Dao Chdh Ftcd Kynu Sardh Ppm1k Echs1 Ddo Agxt Otc Cbs Cth Phykpl Txnrd1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Shmt1 Psmb7 Psmb6 Psmb1 Psmb3 Slc44a1 Psmb2 Slc44a2 Mccc1 Gcsh Mccc2 Psma7 Dbt Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Slc22a4 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Dld Psmd1 Adrm1 Sephs2 Gstz1 Gamt Ckmt1 Ckmt2 Gatm Slc6a8 Ckm Slc6a12 Ckb Odc1 Oaz1 Oaz3 Oaz2 Nqo1 Azin1 Slc6a7 Slc6a11 Rida Sds Slc36a4 Sdsl Slc3a2 Cga AC132020.1 Ogdh Dlst Kgd4 Slc7a5 Prodh Glyat Tshb Aanat Scly Tph2 Mat1a Duox1 Tph1 Grhpr Aldh4a1 Ddc Pnmt Got2 Duoxa1 Amt Gnmt Duoxa2 Cav1 Agxt2 Prodh2 Asmt Txndc11 Dio1 Dio2 Dio3 Dbh Duox2 Tpo Th Mpst Iyd Usf1 Slc5a5 Sqor Ethe1 Fmo1 Mri1 Suox Ado Txn2 Bhmt Mtap Enoph1 Tst Adi1 Bhmt2 Gadl1 Cdo1 Slc25a10 Gls Dmgdh Tdo2 Tyrp1 Ido2 Hpd Ido1 Slc45a2 Pycr3 Pycr2 Pycr1 Glud1 Aldh6a1 Kyat1 Dhtkd1 Asl Tyr Hal Hykk Pah Acadsb Glul Gpt Phgdh Auh Aadat Agmat Slc25a21 Gcdh Folh1 Arg2 Got1 Arg1 Slc25a15 Ivd Slc25a12 Aass Slc25a13 Oca2 Oat Hdc Bbox1 Aoc1 Fah Asrgl1 Slc25a2 Amdhd1 Aldh9a1 Hsd17b10 Acat1 Ahcy Serinc4 Serinc5 Mtrr Serinc2 Aldh18a1 Hgd Serinc1 Haao MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10222827 MyD88:MAL(TIRAP) cascade initiated on plasma membrane Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Tirap Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 TCR SIGNALING%REACTOME%R-RNO-202403.1 TCR signaling Pdpk1 Prkcq Plcg1 Csk Cdc34 Ube2d2 Inpp5d Pik3ca Pak1 Pak3 Psma4 Pak2 Psma3 Cd101 Pag1 Psma6 Pik3r1 Ptprc Psma5 Pik3cb Fyb1 Psma2 Psma1 Rps27a Pik3r2 Psmd12 Psmd11 Psmd14 Psmd13 Ikbkb Skp1 Lcp2 Psmb5 Psmb4 Traf6 Psmb7 Psmb6 Ikbkg Psmb1 Map3k7 Psmb3 Ube2n Psmb2 Uba52 Nfkb1 Pten Ube2d1 Fbxw11 Btrc Nck1 Psma7 Zap70 Rela RT1-Db2 Cd3g Psmc5 Cd247 Psmc2 RT1-Db1 Psmc1 Cd3e Psmc4 Cd3d Psmc3 Trav19 AC109737.1 Cd4 RT1-Ha Trat1 Lck Ptpn22 Itk RT1-Ba RT1-Bb Plcg2 Ubb ENSRNOG00000065955 Malt1 Ubc Trbv16 Bcl10 RT1-Da Ripk2 Grap2 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Nfkbia Tab2 Chuk Lat RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 96%10225099 RUNX1 regulates transcription of genes involved in BCR signaling Cbfb Pax5 Elf2 Runx1 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223469 ABC-family protein mediated transport Os9 Abcc1 Rnf5 Abcc2 Sel1l Abcc3 Abcb1 Psma4 Psma3 Psma6 Apoa1 Psma5 Kcnj11 Psma2 Abcf1 Psma1 Abcb6 Abcc9 Rps27a Abcb7 Psmd12 Abcb4 Psmd11 Abcb5 Abcb8 Psmd14 Abcb9 Psmd13 Abcg4 Abcg8 Eif2s3 Abcg5 Abcc5 Abcc6 Eif2s2 Abca12 Abcc10 Eif2s1 Psmb5 Abca2 Psmb4 Pex3 Abca5 Psmb7 Abca6 Psmb6 Abca9 Abca7 Psmb1 Abca8 Psmb3 Psmb2 Uba52 Abcd1 Abcd2 Abcd3 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Abca3 Pex19 Ubb Ubc Abcc4 Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Derl3 Psmd2 Derl2 Psmd1 Adrm1 Erlin2 Erlin1 Vcp Erlec1 Cftr NFG AND PRONGF BINDS TO P75NTR%REACTOME DATABASE ID RELEASE 96%10223189 NFG and proNGF binds to p75NTR Ngfr Ngf SIGNALING BY NTRK1 (TRKA)%REACTOME%R-RNO-187037.1 Signaling by NTRK1 (TRKA) Ppp2cb Ppp2ca Frs2 Ntrk1 Ngf Ppp2r5d Creb1 Pik3ca Shc1 Braf Ppp2r1b Ppp2r1a Mapk3 Crkl Pik3r1 Rapgef1 Rhoa Rps6ka5 Pik3cb Nras Chd4 Pik3r2 Grb2 Rap1a Kras Sos1 Hras Atf1 Mapk7 Irs2 Nab2 Dnal4 Egr2 Vrk3 Sgk1 Map2k2 Rps6ka3 Map2k1 Rps6ka1 Irs1 Rps6ka2 Dusp3 Ap2m1 Srf Dusp4 Clta Dusp7 Cltc Dusp6 Shc3 Shc2 Mapkapk3 Mapk14 Mapkapk2 Ap2s1 Mapk1 Ralgds Ap2a2 Ap2a1 Ap2b1 Sh3gl2 Mapk11 Ywhab Crk Kidins220 PYRIMIDINE CATABOLISM%REACTOME%R-RNO-73621.1 Pyrimidine catabolism Tymp Upb1 Upp1 Nt5c3a Nt5c Upp2 Nt5c1a Dpys Dpyd Nt5e Nt5m METAL ION SLC TRANSPORTERS%REACTOME%R-RNO-425410.1 Metal ion SLC transporters Slc8a1 Slc30a10 Slc8a2 Slc40a1 Slc8a3 Heph Slc8b1 Slc41a2 Slc41a1 Slc11a1 Calm3 Slc9a1 Slc9a4 Slc9a5 Slc9a2 Slc9a3 Slc9a8 Slc11a2 Slc9a9 Slc9a6 Slc9a7 Slc39a4 Slc39a3 Slc39a2 Slc39a1 Slc39a8 Slc30a5 Slc39a7 Slc30a8 Slc39a6 Slc39a14 Slc24a5 Slc31a1 Slc24a4 Slc24a3 Slc30a1 Slc24a2 Slc24a1 Sri Cp SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-RNO-416572.1 Sema4D induced cell migration and growth-cone collapse Rhoc Erbb2 Rnd1 Rhob Arhgef11 Rock2 Sema4d Rock1 Rhoa Arhgef12 Plxnb1 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-RNO-176408.1 Regulation of APC C activators between G1 S and early anaphase Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Plk1 Psmd2 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-RNO-5218920.1 VEGFR2 mediated vascular permeability Pdpk1 Ctnnb1 Rictor Ctnna1 Prr5 Jup Trib3 Calm3 Ctnnd1 Mapkap1 Them4 Pak1 Rac1 Cav1 Pak3 Mtor Pak2 Akt3 Akt2 Akt1 Hsp90aa1 Vav3 Nos3 Vav1 Vav2 Mlst8 DRUG ADME%REACTOME%R-RNO-9748784.1 Drug ADME Itpa Slco2b1 Gsta5 Gsta6 Gsta3 Sult1a1 Gsta1 Gsta2 Akr1c18 Abcg2 Abcc1 Akr1c12l1 Akr1c19 Abcc2 Sult2a2 Ugt1a2 Ugt1a1 Ugt1a3 Sult2a1 Ugt1a5 Sult2a6 Akr1c21 Abcb1 Ugt2b1 Hsd11b1 Cndp2 Hsd11b2 Ugt2b7 AC114845.1 Ugt2b34l1 Ggt1 Ugt2b Ggt5 Serpina6 Ggt7 Akr1c3l1 Akr1c12 Ggt6 Akr1c1 Akr1c13 Alb Gstp1 Ugt2b17 Ugt2b37 Ugt2b15 Gstt1 Akr1c9 Pnp Adk Hprt1 Ada Slc22a2 Slc22a1 Abcc5 Ugt1a6 Ugt1a7 Ugt1a8 Nat1 Nat2 Nat3 Ugt2a1 Ugt2a3 Gmps Ces2h Pon3 Impdh2 Pon1 Acy1a Impdh1 Ugt3a1 Bche Slc22a3 Xdh Bsg Ces1d Glyatl3 Acsm2 Acsm4 Acsm5 Glyat Abcc3 Rac1 Vav3 Nme2 Vav1 Vav2 Nme1 Cyp3a9 Cyp3a18 Adh1 Cyp2c66 Cyp2e1 Cyp2c11 Slc22a7 Cyp3a1 Cyp2d4 Cyp3a62 Cyp3a2 Abcc4 Slc16a1 Slc28a3 Slc28a2 Tpmt Slco1a4 Slc29a3 Slc29a2 Slco1b2 Sult1e1 Slc29a1 Nt5c2 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME DATABASE ID RELEASE 96%10225197 Biosynthesis of E-series 18(S)-resolvins Gpx4 Hpgd Alox5 Lta4h Alox15 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%10225531 CHD3, CHD4, CHD5 subfamily Rbbp4 Rbbp7 H2ac18 Hist1h2bq Hdac1 H2aj H3-3b Hist3h2ba ENSRNOG00000068602 Chd3 Chd4 Mbd2 Mta1 H2bc18 Mta2 Mta3 Mbd3 H2az2 Cbx3 H2bc4 Hist1h4m H2bc1 Gatad2a Gatad2b Hist1h2ai Ube2i Hdac2 Nr2c2 H2ab2 Zmynd8 Ikzf3 Ikzf1 Zfp827 Zfp532 Adnp H2ac4 Cbx1 Phf6 Zfp592 Cdk2ap1 Nr2f2 Chd5 Tcf19 ENSRNOG00000066901 Pwwp2a Mbd3l1 Mbd3l2 Sumo1 Zfp687 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-RNO-1852241.1 Organelle biogenesis and maintenance Ywhag Sirt5 Sirt3 Rpgrip1l Ift140 Kif3a Mks1 Ift52 Ttc21b Ift57 Ift122 Ofd1 Wdr35 Dync2h1 Ift172 Wdr19 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Pcm1 Dynlrb2 Ssna1 Dynlrb1 Ift70b Tubg1 Ift81 Cep63 Dynlt2b Sstr3 Ift80 Cep152 Dynlt5 Tuba4a Dynlt2 Cycsl2 Haus4 Gabpa Haus5 Kif17 Haus6 Trip11 Pcnt Sfi1 Dync2i1 Dync2li1 Haus1 Dync2i2 Cluap1 Traf3ip1 Ift20 Cep250 Ift22 Idh2 Cep290 Cep78 Ift27 Cep76 Ift25 Cep72 Ift56 Acss2 Cep164 Cep70 Ift43 Cpap Cycs Tubb5 Ift46 Plk4 Ift74 Odf2 Ift70a2 Alms1 Sod2 Cetn2 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Pde6d Mt-atp6 Atp5mc1 Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Dmac2l Mchr1 Atp5mg Atp5f1b Atp5f1a Atp5po Hsp90aa1 Atp5mk Mt-atp8 Rab11a Kifap3 Kif3b Kif3c Nek2l1 Rho Ywhae Plk1 Cdk1 Rab3ip Actr1a Dctn1 Dctn2 Prkaca Cc2d2a Tmem67 C2cd3 Rab8a Mark4 Cep162 Septin2 Kif24 Ttbk2 Tctn3 Fbf1 Tctn1 Akap9 Tctn2 Iqcb1 B9d1 Cep89 Ahi1 Nphp4 Cep83 Nphp1 Sclt1 Tmem216 Prkar2b Ppp2r1a Arf4 Cep97 Csnk1d Ccp110 Gbf1 Mkks Unc119b Arl13b Pkd1 Rp2 Asap1 Bbs9 Bbs7 Bbs5 Bbs4 Cct3 Cct2 Bbs10 Bbs12 Thoc2l Cngb1 Exoc3 Exoc4 Exoc5 Exoc6 Exoc1 Exoc2 Exoc7 Exoc8 Tcp1 Inpp5e Arl6 Arl3 Cnga4 Cnga2 Bbip1 Cct8 Cct5 Cct4 Bbs2 Atat1 Ttc8 Nphp3 Lztfl1 Pafah1b1 Dync1h1 Dync1i2 Tnpo1 B9d2 Nde1 Glud1 Clasp1 Smo Mapre1 Dynll1 Dynll2 Ckap5 Csnk1e TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-RNO-727802.1 Transport of nucleotide sugars Slc35d1 Slc35b4 Slc35a1 Slc35a3 Slc35c1 Slc35a2 Slc35b3 Slc35b2 Slc35d2 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-RNO-9970672.1 FXIIa activates plasma kallikrein-kinin system Prcp Hist1h2ai F12 H2ab2 H3-3b Hist3h2ba A2m H2ac4 Hrg H2ac18 Klkb1 ENSRNOG00000068602 Plaur Kng1 H2bc18 Serping1 C1qbp Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m H2az1 H2bc1 Krt1 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-RNO-205043.1 NRIF signals cell death from the nucleus Aph1b Itgb3bp Uba52 Ngf Sqstm1 Rps27a Psenen Ngfr Psen1 Psen2 Ubb Ncstn Ubc Aph1a Traf6 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-RNO-69560.1 Transcriptional activation of p53 responsive genes Zfp385a Tp53 PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-RNO-3214841.1 PKMTs methylate histone lysines Prdm9 Suz12 Eed Nsd2 Nfkb2 Nfkb1 Kmt2d Ehmt1 Rbbp4 Kmt2a Rbbp7 Kmt2b Kmt2c Rela Setdb2 Setdb1 Dot1l Setd3 Nsd3 Setd2 Setd7 Setd6 Nsd1 Ash1l Suv39h2 Wdr5 Smyd2 Ash2l Mecom Suv39h1 Smyd3 Aebp2 Kmt5b Atf7ip Prdm16 Kmt5a Setd1b Setd1a H2bc18 Rbbp5 Ezh2 Kmt5c Hist1h4m TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-RNO-933542.1 TRAF6 mediated NF-kB activation Ikbkg Nfkbib Nfkb2 Nfkb1 Ager Nfkbia Hmgb1l2 Rela Hmgb1l1 Nkiras1 App Chuk S100b Ikbkb Nkiras2 Hmgb1-ps34 GAP JUNCTION ASSEMBLY%REACTOME%R-RNO-190861.1 Gap junction assembly Gja10 Gjc1 Gjd2 Gjd4 Gjb2 Gjd3 Gjb1 Gjc2 Gja3 Gjb4 Gjb3 Gja5 Gjb6 Gjb5 Gja4 Gja8 Gja1 TRANSLATION%REACTOME%R-RNO-72766.1 Translation LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Ube2d3 Ube2d2 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a LOC134480579 Rpl23a Mief1 Mtrf1l Trip4 Eif5 Mt-cyb Pelo Gfm1 Gfm2 Srp68 Mrrf Srp9 Mrps9 Mrps2 Mt-atp6 Mrps7 Mrps5 Mt-nd4l Tcf25 Srp54 Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Psma4 Mrps31 Mrps33 Psma3 Mrps34 Mrps35 Mrpl43 Psma6 Mrpl44 Psma5 Mrpl45 Psma2 Mrpl46 Mt-atp8 Psma1 Mrpl48 Eef1d Rps27a Mtrf1 Eef1b2 Mrpl49 Eef1g Psmd12 Eef1a1 Mrps21 Psmd11 Mrps22 Rps14 Mrps23 Psmd14 Rps15 Mrps24 Psmd13 Rps16 Mrps25 Rps17 Mrps26 Rps15a Mrps27 Rps18 Malsu1 Rps19 Mrpl51 Pabpc1 Mrpl32 Psmb5 Rpsa Mrpl33 Rps10 Psmb4 Oxa1l Rps11 Psmb7 Mrpl34 Rps13 Psmb6 Mrpl35 Rps4x-ps13 Mrpl36 Psmb1 Mrpl37 Rps3a Rps27l Psmb3 Mrpl38 Psmb2 Rps9 Mrps10 Uba52 Rps7 Mrpl39 Rps8 Mrps12 Rps5 Chchd1 Ube2d1 Mrps15 Eif4h Rps26-ps13 Mrpl40 Ndufab1 Mrpl41 Eif3m Mrpl42 Eif3j Psma7 Mrpl21 Eif3i Mrpl22 Eif3l Mrpl23 Eif3k Mrpl24 Eif3f Psmc5 Mrpl27 Eif3e Psmc2 Mrpl28 Eif3h Psmc1 Srp14 Eif3g Psmc4 ENSRNOG00000068816 Eif3b Psmc3 Eral1 Eif3a Srp19 Eif3d Mrpl30 Eif3c Rps3 Mrpl10 Rps25 Mrpl11 Mrpl12 Rps4x Rps26 Mrpl13 Rps28 Ubb Mrpl14 Rps29 Mrpl15 Rps20 Ubc Mrpl16 Rps21 Mrpl17 Rps23 Mrpl18 Psmb6l1 Rps24 Ascc3 Eif1ax Ascc2 Eif4a2 Psmd7 Mrpl19 Eif4a1 Eif5b Psmd6 Fau Nemf Psmd8 Zfp598 Gadd45gip1 Psmd2 Mt-co3 Eif4ebp1 Mt-co2 Psmd1 Mrpl20 Mrpl3 Adrm1 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Klhdc10 Ptcd3 Mt-co1 Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Rps6 Mt-nd3 Mt-nd2 Eif4e Ppa1 Ppa2 Eef2 Apeh Rps2 Eloc Elob Ltn1 AC132020.1 Kgd4 Cul2 Eif2b3 Eif2b2 Eif2s3 Eif2b5 Rpl4 Eif2b4 Rpl5 Eif2s2 Rpl3 Eif2b1 Rps27 Eif2s1 Rpl35 Rpl36 Rpl37 Rpl38 Rpl39 Rpl8 Rpl9 Rpl6 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rchy1 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Rbx1 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Hbs1l LOC100910714 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 96%10224139 Endosomal Vacuolar pathway RT1-M10-ps1 RT1-M10-ps5 RT1-M6-2 RT1-M1-5 AABR07044308.1 Rt1-ec3 RT1-M2 B2m RT1-N3 Lnpep RT1-M1-2 RT1-M5 PTK6 DOWN-REGULATION%REACTOME%R-RNO-8849472.1 PTK6 Down-Regulation Ptpn1 Srms Ptk6 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-RNO-447115.1 Interleukin-12 family signaling Il27 Vamp7 Il23a Il12a Crlf1 Canx Jak2 Il23r Stat3 Stat1 P4hb Tyk2 Il12rb1 Il12rb2 Il6st Ebi3 Il12b GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-RNO-159854.1 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins Pros1 F10 F7 F9 Ggcx Bglap Furin Gas6 F2 Proc Proz SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-RNO-1855204.1 Synthesis of IP3 and IP4 in the cytosol Itpk1 Pten Itpka Itpkc Itpkb Plcg1 Inpp5b Plch1 Pld4 Plcd1 Plcd4 Ocrl Inpp5j Plcd3 Calm3 Synj1 Plcz1 Plce1 Plcg2 Inpp5d Plcb4 Plcb3 Inppl1 Plcb2 Plcb1 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222941 Classical antibody-mediated complement activation C1qb Crp C1qa C1s C1r C1qc ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-RNO-9623433.1 LXRs regulate gene expression to control bile acid homeostasis Ncor2 Nr1h3 Nr1h2 Rxrb Rxra METALLOTHIONEINS BIND METALS%REACTOME%R-RNO-5661231.1 Metallothioneins bind metals Mt2 Mt3 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 96%10223481 Platelet degranulation Aldoa Serpina3n Timp3 Fam3c Serpinf2 Tln1 F13a1 Anxa5 Fn1 Calm3 Qsox1 Pdgfa Pdgfb Brpf3 Vegfa Lgals3bp Alb Vegfd Vegfc Lamp2 Vegfb Wdr1 Apoa1 Maged2 Kng1 Endod1 App Serpina4 F8 Actn2 Habp4 Cdc37l1 Serpina1 Tagln2 Cd36 Itih4 Itih3 Pros1 Cd109 Nhlrc2 Fermt3 Lefty2 Thbs1 Manf AABR07021573.2 Lefty1 Igf2 Igf1 Hgf Sparc Apoh Vcl Gtpbp2 Orm1 Ecm1 Tuba4a Ola1 Ctsw Psap Actn4 Ppbp Flna Tmsb4x Cd63 Tor4a Tgfb1 Tgfb2 Tgfb3 Fgb Fga Fgg Pcdh7 Tmx3 Itga2b Scg3 Selp Plg Cyrib Sccpdh Egf Srgn Serping1 Pecam1 Itgb3 Clu Actg1 Actn1 Aplp2 Timp1 Cyb5r1 Mmrn1 Cd9 Plek Sod1 A2m Tf Phactr2 Stxbp2 Vti1b Chid1 Abcc4 Cfd Pf4 A1bg Rab27b Serpine1 Islr Pcyox1l Hrg Lhfpl2 Gas6 Sytl4 Ly6g6f Ahsg Spp2 ICOS CO-STIMULATION%REACTOME%R-RNO-9927354.1 ICOS co-stimulation Pik3r5 Pik3cg Pik3r2 Pik3r3 Pik3ca Pik3cd Pik3r6 Icoslg Icos Pik3r1 Pik3cb ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 96%10224247 Acyl chain remodeling of CL Hadha Pla2g4a Hadhb Tafazzin Lclat1 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-RNO-74160.1 Gene expression (Transcription) Ddx21 Snapc3 Snapc4 Snapc1 Snapc2 Polr3gl Gtf3a Crcp Polr3a Brf2 Polr3d Brf1 Polr1c Polr3e Polr3b Polr3c Polr3f Polr3g Gtf3c2 Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 Lamtor3 Gtf3c5 Lamtor2 Bdp1 Ran Ywhab Gpx2 Wwox Txnrd1 Gsr Ccne1 Ccne2 Steap3 Tfdp2 Tfdp1 Rbl1 Rpa1 Rpa2 Rpa3 E2f4 E2f5 Cdkn1b Rptor RragB Ppm1a Mtor Rheb Slc38a9 Lamtor5 Lamtor4 Rraga Lamtor1 Lbr Rragc Rragd Stk11 Mlst8 Rnf111 Blm Wrn Dna2 Paxip1 Mre11 Ube2i Eloc Kat5 Elob Nbn Hus1 Atrip Baz1b Chek1 Chek2 Rad9a Rad9b Bard1 Top3a Rad17 Atm Atr Exo1 Rmi2 Rmi1 Brip1 Smarca5 Sumo1 Rhno1 Rad50 Ehmt1 Ing5 Setdb1 Brd1 Topbp1 Rbbp8 Brca1 Rad1 Smyd2 Aebp2 Atf7ip Brpf1 Kat6a Meaf6 Sfn Plk3 Prdm9 Rnf34 Phf20 Gls Gpi Cdc25c Mdm4 Ywhaq Ywhah Ywhaz Zfp385a Pdpk1 Ctnnb1 Men1 Sirt3 Gls2 Tcf7 Tcf7l1 Tcf7l2 Cdc73 Pcf11 Fip1l1 Cstf1 Zfp473 Papola Nudt21 Cstf2 Cstf3 Cstf2t Lsm10 Lsm11 Sympk Pabpn1 Clp1 Smurf2 Cpsf4 Cpsf6 Cpsf7 Lef1 Cpsf1 Cpsf2 Cpsf3 Leo1 Cavin1 Banp Slbp Txn Cycsl2 Cycs Psma4 Ccna1 Psma3 Polr1b Polr1a Ccna2 Polr1f Psma6 Polr1g Psma5 Polr1e Psma2 Polr1h Psma1 Chd3 Rps27a Chd4 Psmd12 Taf1d Psmd11 Rrn3 Taf1a Psmd14 Taf1c Psmd13 Taf1b Mta1 Mta2 Mta3 Nr1h3 Mbd3 Cbx3 Nr1h2 Ercc6 Psmb5 Ubtf Gatad2a Psmb4 Rxrb Gatad2b Psmb7 Rxra Psmb6 Ccnb1 Psmb1 Psmb3 Pgr Psmb2 Rxrg Uba52 Tbl1x Ube2d1 Psma7 Aurka Cited1 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Esr2 Psmc3 Cdk9 Hdac3 Ubb Pou2f1 Tbl1xr1 Rara Ubc Foxo3 Psmb6l1 Npm1 Psmd7 Ppard Rb1 Psmd6 Psmd8 Psmd2 Mt-co3 Mt-co2 Psmd1 Ncor2 Adrm1 Gps2 Cdk2 Cdk1 Ncoa3 Rarg Mapk1 Mt-co1 Nr5a2 Notch4 Ppp2cb Ppp2ca Zfp839 Ddit4 Higd1c Cited4 Cited2 Zfp819 Plk2 Igfbp3 Phax Tmem219 Ell2 Ell3 Btg2 Zik1 Cdk5r1 Zfp867 Zfp866 Mtf2 Zfp612 Zim1 Zfp617 Zfp605 Zfp46 Zfp804b Ipo8 Rprd1a Rprd1b Supt6h Sesn2 Zfp418l1 Ppp2r1b Sesn1 Ppp2r1a Cnot11 Cdk5 Sesn3 Kdm5b Tfap2e Cnot10 Npas4 Tp53rkb Tp53rka Zfp52 Znf354c Znf354b Mybbp1a Znf354a Tnks1bp1 Zfp90 Zfp78 Zfp74 Tsn Maged1 LOC102546572 Zfp81 Skil Mterf1 Cox7a1 Cox7a2 Mllt3 Mllt1 Atp1b4 Zfp873l3 Ints4 Ints5 Ints6 Zfp398 Ints7 Ints8 Ints9 Cox7a2l Ints1 Ints2 Ints3 Zfp386 Cnot6l Zfp764l1 Ttf1 Rffl Zfp133 Znf382 Cradd Pidd1 Znf394 Tpx2 Tp63 Nabp1 Nabp2 Esrra Tp53 Esrrb Zfp273l-ps1 Esrrg Skic8 Ezhip Zfp180 Zfp189 Zfp184 Parp1 Ccng1 Tsnax Zfp169 H2ab2 LOC102547287 Arid1a Zfp94l1 Arid1b LOC108348267 Lmo2 Zfp455l1 Lmo3 Zfp790 Ccnh Zfp317 H2ac4 Zfp799 Serpinb13 Zfp300 Zfpm1 Actl6a Zfp786 Actl6b Zfp788 Smarce1 Rsl1 Gata3 Zfp770 Gata1 Znf773 Gata2 Zfp775 Setd1b Yeats4 Setd1a Morc2 Wwtr1 Ring1 Abl1 Zfp764 ENSRNOG00000066901 Zfp763 Tp73 Jmy Ccnd2 Zfp111 Phc2 Zfp113 Cbx6 Zfp597 Ccnd3 Znf750 Phc1 Tgif1 Cbx4 Tgif2 Sf3b1 Cbfb Zfp599 Ccnd1 Nr1d2 Cbx2 Nr1d1 Esr1 Zfp583 Phc3 Zfp101 Dyrk2 Kmt2d Ndufa4 Crebbp Cdk7 Iws1 Cdk6 Dek Trim33 Kmt2a Znf740 Kmt2b Zfp566 Kmt2c H2ac18 Zfp324 Bax Tcf3 Sin3a LOC120095871 Sin3b Nr1i3 Zfp954 Csnk2a2 Zfp951 Ctsk Zfp790l2 Ctsl Rnmt Zfp710 Csnk2a1 Zfp952 Srrt Bmi1 Mnat1 Znf18 Pbrm1 Zfp719 Brd7 Prdx2 Prmt6 Actg1 Prdx5 Hist1h2bq Zfp704 Prmt1 Zfp945 Smarcb1 Zfp703 Hdac1 Wdr5 Zfp706 Ash2l Zfp948 ENSRNOG00000070049 Yaf2 Csnk2b L3mbtl1 Pax5 Ezh1 H2aj Tp53bp2 Nrbf2 Elf1 Nrbf2l1 Elf2 Tal1 Tead4 Zfp758 Smarca2 Zscan25 Smarca4 Zscan22 Foxp3 Pou2f2 H3-3b Zfp746 Yap1 Hist3h2ba Krba1 Ep300 Pcgf6 Noc2l Rnf2 ENSRNOG00000068602 Tead3 Ski Itch Tead2 Smarcd1 Tcf12 Tigar Zfp964 Smarcd3 Pcgf5 Hipk1 Cox6a1 Smarcd2 Ptpn11 Cox6a2 Zfp286a H2bc18 Rabggta Runx1 Kat2b Rabggtb Ppp1r13l H2az2 Ppp1r13b Rbbp5 Zfp119bl H2bc4 Hist1h4m Max Jarid2 H2bc1 Pml Cox6c2 Cnot3 Smarcc1 Cnot2 Hist1h2ai Cnot1 Nek4 Cnot7 Cnot6 Cnot4 Rorc Cnot9 Rorb Cnot8 Ints13 Ints14 Cox6b1 Ints11 Cox6b2 Ints12 Ints10 Zc3h8 Rngtt Pphln1 Foxg1 Rprd2 Myo1c G6pdx Casp2 Mga Zfp37-ps1 Tbx5 E2f6 E2f7 E2f8 Zfp275 Epc1 Zfp1 Zfp266 Zfp263 Nr6a1 Zfp496 Zfp808l3 Prkaa1 Pip4p1 Eaf1 Prkaa2 Eaf2 Zfp483 Cox8a Rpap2 Cox8c Zfp248 Nuak1 Hnf4a Cox7b Foxo1 Hnf4g Cox7c Prkag3 Zkscan8 Prkag1 Zkscan7 Prkag2 Zkscan1 Zkscan4 Zkscan5 Zkscan3 Bnip3l Nr4a3 Mapkapk5 Nr4a2 Ezh2 Zfp955a Zfp955b Bmal1 Nrif1 Ywhag Runx3 Suz12 Cox5a Cox5b Zfp12 Eed Zfp13 Gsk3b Zfp950l16 Zfp282 Ttc5 Nr2c1 Ice2 Kctd1 Rbbp4 Pou4f1 Rbbp7 Znf431l2 Pou4f2 Tasor Prkab2 Zfp668 Prkab1 Znf689 Zfp664 ENSRNOG00000065205 Zfp658 Zfp655 Ssu72 Znf624l Ube2d3 Zfp641 Phf19 Zfp647 Znf667 Znf426 Aff4 Cox4i1 Tfb2m Cox4i2 Tfam Nr2f6 Polrmt Nr0b2 Nr0b1 Nr2f1 Nr2e3 Gadd45a Zfp212 Epop Zfp213 Zfp455 Tnrc6c LOC134478826 Mapk3 Rex2l4 Tnrc6a Tnrc6b Zfp445 Zfp688 Zfp950l5 Usp9x Map2k6 Kat2a Maml3 Rbpj Hdac2 Hdac5 Hdac4 Mapk14 Maml1 Hdac11 Maml2 Hdac10 Notch3 Hdac9 Hdac8 Mapk11 Cpap Tgfb1 Ncoa2 Furin Nr1h4 Ell Ccnk Tcea1 Ccnt2 Cdk13 Cdk12 Ssrp1 Eloa2l Eloa Akt3 Akt2 Akt1 Mbd2 Tsc2 Tsc1 Cbx5 Prkra Ago4 Ago3 Ago2 Ago1 Dicer1 Tarbp2 Chm Ywhae Brpf3 Src Dnmt3a Atad2 Lhb Cga Rfc5 Rfc3 Rfc4 Pcna Rfc2 Kmt5a Sirt1 Sp1 Mphosph8 Med23 Med24 Med20 Tasp1 Akap8l Cxxc1 Kat8 Med27 Med12 Med1 Yeats2 Med13 Med14 Wdr82 Med10 Ccnc Med4 Pparg Med6 Kat14 Mbip Hcfc1 Med16 Med17 Hcfc2 Dr1 Kansl3 Kansl1 Kansl2 Phf20l1 Ajuba Bod1l1 Pagr1 Tada3 Med30 Tada2a Med31 Ppargc1a Ppargc1b Mcrs1 Zzz3 Sgf29 Psip1 Snrpf Ogt Snrpg Snrpb Nr2c2 Prmt5 Ctr9 Paf1 Smurf1 Snrpd3 Snrpepl2 Arnt2 Arnt Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe Polr2j Ctdp1 Ncbp2 Ncbp1 Gtf2h2 Gtf2h1 Supt4h1 Gtf2f2 Gtf2f1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Myc Ar Foxo4 Atxn3 Usp2 Usp7 Smad2 Smad3 Smad4 Smad7 Suv39h1 Rrp8 Nr1i2 Nr3c2 Nr3c1 Vdr Dnmt1 L3mbtl2 Daxx Ing2 Ppara Trim28 Pcgf2 Thrb Thra Nr5a1 Prdx1 Taf9 Taf9b Tfap2c Tfap2a Taf15 Tfap2b Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Taf7l-ps1 Gtf2a1 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Tdg Taf4 Taf2 Taf1 Gtf2e2 Pip4k2b Pip4k2c Pip4k2a Foxo6 Sgk1 Nr4a1 Rictor Prr5 Mapkap1 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-RNO-3249367.1 STAT6-mediated induction of chemokines Stat6 Sting1 Tbk1 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-RNO-8981607.1 Intracellular oxygen transport Cygb Mb Ngb SERINE METABOLISM%REACTOME%R-RNO-977347.1 Serine metabolism Phgdh Serinc4 Serinc5 Psph Serinc2 Psat1 Sds Serinc1 Sdsl Srr FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME DATABASE ID RELEASE 96%10223703 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Plcb3 Gna11 Gna14 Plcb2 Plcb1 Ffar1 Gnaq CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-RNO-446353.1 Cell-extracellular matrix interactions Arhgef6 Pxn Fblim1 Parvb Parva Ilk Fermt2 Flna Flnc Vasp Itgb1 Actn1 Tesk1 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME%R-RNO-168643.1 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Ikbkg Map3k7 Ube2n Aim2 Birc2 Mapk12 Aamp Nod2 Casp2 Nod1 Casp9 Map2k6 Pycard Panx1 Txnip Ripk2 Sugt1 Nlrp3 Txn Casp1 Mefv Casp8 Pstpip1 Nlrp1a Hsp90ab1 Mapk14 P2rx7 Cyld Itch Tab3 Tab2 Mapk13 Tab1 Bcl2l1 Mapk11 Traf6 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%10223285 TNFR2 non-canonical NF-kB pathway Birc2 Uba3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Tnfsf13 Psmd12 Psmd11 Psmd14 Eda Psmd13 Tnfrsf4 Tnfrsf8 Tnfrsf1b Edar Tnfrsf11b Skp1 Tnfrsf11a Cd40lg Psmb5 Tnfsf4 Psmb4 Psmb7 Cd40 Tnfsf13b Psmb6 Tnfsf11 Psmb1 Tnfsf8 Psmb3 Tnfsf9 Psmb2 Relb Uba52 Tnfrsf9 Nfkb2 Lta Ltb Traf2 Tnfrsf17 Edaradd Tnf Fbxw11 Tnfsf15 Btrc Tnfsf14 Tnfrsf1a Psma7 Tnfsf12 Tnfrsf13c Tnfsf18 Ltbr Psmc5 Tnfrsf25 Ube2m Psmc2 Eda2r Psmc1 Tnfrsf18 Psmc4 Tnfrsf12a Psmc3 Map3k14 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Traf3 Chuk INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223463 Intestinal lipid absorption Npc1l1 PYRUVATE METABOLISM%REACTOME%R-RNO-70268.1 Pyruvate metabolism Pdp1 Pdpr Pdp2 Uba52 Pkml1 Pdha1 Pdha2 Ranbp9 Ldhal6b Glo1 Wdr26 Hagh Nek1 Ubb Mkln1 Fahd1 Ubc Gid4 Maea Ldha Gpt Ldhb Ldhc Armc8 Me1 Me3 Me2 Rmnd5b Dld Pdhx Pgam5 Vdac1 Rps27a Pc Pdk4 Pdk3 Dlat Pdk2 Pdk1 Pklr Pdhb Gstz1 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 96%10222929 Signalling to RAS Shc3 Shc1 Mapkapk3 Shc2 Mapk14 Mapkapk2 Nras Ralgds Grb2 Kras Sos1 Hras Mapk11 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-RNO-202131.1 Metabolism of nitric oxide: NOS3 activation and regulation Zdhhc21 Cav1 Ddah1 Nostrin Cyb5b Akt1 Nosip Spr Lypla1 Hsp90aa1 Nos3 Cygb Dnm2 Calm3 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%10222193 Caspase activation via extrinsic apoptotic signalling pathway Casp8 Traf2 Dcc Appl1 Tradd Cflar Ripk1 Tnfsf10 Fas Fadd Casp3 Faslg Casp9 Ly96 Ticam2 Ticam1 Cd14 Tlr4 COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 96%10225481 Complex IV assembly Mt-co2 Cox18 Tmem177 Cox20 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 96%10223423 Apoptosis induced DNA fragmentation Hmgb1l2 Hmgb1l1 H1-1 H1-0 H1-5 H1-4 H4f3 Hmgb2 Dffa Casp3 Dffb Kpnb1 Hmgb1-ps34 Kpna1 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 96%10222555 G alpha (12 13) signalling events Rhoc Adra1b Adra1a Adra1d Arhgef7 Rock2 Rock1 Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Rhoa Arhgef10 Arhgef12 Ngef Arhgef19 Vav3 Akap13 Vav1 Vav2 Sos1 Itsn1 Arhgef26 Arhgef25 Sos2 Kalrn Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Plxnb1 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Rhob Tbxa2r Btk Rasgrf2 Gna12 Mcf2 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224473 Syndecan interactions Itga2 Prkca Sdc1 Fgf2 Itgb1 Itga6 Sdc4 Itgb3 Sdc3 Itgb4 Sdc2 Itgav Vtn Tgfb1 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-RNO-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates Mre11 Slx4 Eme2 Kat5 Spidr Eme1 Rad51 Rad50 Nbn Gen1 Rad51c Rad51b Rbbp8 Brca2 Brca1 Rad51ap1 Bard1 Top3a Palb2 Firrm Xrcc3 Slx1b Xrcc2 Atm Exo1 Mus81 Rmi2 Fignl1 Rmi1 Blm Brip1 Wrn Dna2 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-RNO-4551638.1 SUMOylation of chromatin organization proteins Phc1 Nup133 Suz12 Sumo3 Cbx4 Nup210 Nup155 Nup153 Cbx2 Phc3 L3mbtl2 Pcgf2 Bmi1 Satb2 Satb1 Hdac1 Sumo2 Rnf2 Hist1h4m Ube2i Nup93 Nup50 Nup35 Nup54 Nup98 Hdac2 Nup58 Nup37 Hdac4 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Pias1 Nup62 Pias2 Nup43 Ring1 Nup88 Aaas Ranbp2 Phc2 Sumo1 Nup214 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-RNO-159782.1 Removal of aminoterminal propeptides from gamma-carboxylated proteins Pros1 F10 F7 F9 Bglap Furin Gas6 F2 Proc Proz G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10222897 G2 M DNA replication checkpoint Ccnb1 Pkmyt1 Ccnb2-ps2 Ccna1 Wee1 Ccna2 Ccnb2 Cdk1 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME%R-RNO-9909505.1 Modulation of host responses by IFN-stimulated genes Ikbkg Ube2l6 Isg15 Fkbp5 Chuk Arih1 Ifi44 Ifi44l Ikbkb Rig1 Trim25 Uba7 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223787 Inorganic anion exchange by SLC26 transporters Slc26a11 Slc26a6 Slc26a4 Slc26a3 Slc26a9 Slc26a2 Slc26a1 Slc26a7 CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 96%10225063 CREB3 factors activate genes Mbtps1 Creb3l3 Crebrf REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-RNO-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins Hist1h2ai Cbx5 Znf431l2 Zfp324 H2ac18 LOC120095871 Setdb1 ENSRNOG00000065205 Trim28 Znf382 Znf624l Zfp719 Zfp867 Hist1h2bq ENSRNOG00000070049 H2aj Zfp808l3 Atf7ip H2ab2 Zfp758 H3-3b Rex2l4 Hist3h2ba Zfp317 H2ac4 ENSRNOG00000068602 Zfp52 Zfp950l5 Zfp964 Znf354a H2bc18 ENSRNOG00000066901 H2az2 LOC102546572 H2bc4 Hist1h4m H2bc1 INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 96%10224713 Intraflagellar transport Kifap3 Kif3b Tnpo1 Kif3c Ift140 Kif3a Ift52 Dynlrb2 Ttc21b Dynlrb1 Ift57 Ift70b Ift122 Ift81 Dynlt2b Ift80 Dynlt5 Wdr35 Dync2h1 Dynlt2 Ift172 Wdr19 Kif17 Trip11 Dync2i1 Dync2li1 Dync2i2 Cluap1 Traf3ip1 Ift20 Dynll1 Ift22 Dynll2 Ift27 Ift25 Ift56 Ift43 Ift46 Ift74 Ift70a2 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME%R-RNO-173599.1 Formation of the active cofactor, UDP-glucuronate Slc35d1 Uxs1 Ugp2 Ugdh G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224093 G protein gated Potassium channels Gng3 Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-RNO-5651801.1 PCNA-Dependent Long Patch Base Excision Repair Polb Fen1 Pole Rfc5 Pold2 Apex1 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pold4 Pold3 Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Lig1 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 96%10225477 PDH complex synthesizes acetyl-CoA from PYR Dlat Dld Pdhx Pdha1 Pdhb Pdha2 G-PROTEIN MEDIATED EVENTS%REACTOME%R-RNO-112040.1 G-protein mediated events Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Gnai2 Gnai1 Prkca Gnai3 Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Grk2 Gnal Gnaq Gnat3 Prkar2a Prkar2b Pde1b Pde1c Pde1a Plcb4 Plcb3 Mapk1 Pla2g4a Plcb2 Plcb1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 DIGESTION%REACTOME DATABASE ID RELEASE 96%10223083 Digestion Cel Pnliprp2 Pnliprp1 Gucy2c Si Lipf Pir Amy2 Alpi Guca2b Guca2a Lct Clps Chia Pnlip Chit1 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 96%10225499 Regulation of PD-L1(CD274) Post-translational modification Ywhag Ddost Ccnd1 Gsk3b Cd274 Os9 Pdcd1 Rnf5 Sel1l Magt1 Mib2 Pdcd1lg2 Prkab2 Prkab1 Csnk2a2 Csnk2a1 Csnk2b Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Nek2l1 Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Prkaa1 Derl3 Psmd2 Prkaa2 Derl2 Psmd1 Stt3b Adrm1 Rbx1 Cul1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Tmem258b Tusc3 Cdk4 Cul3 Erlec1 B3gnt3 Dad1 ATORVASTATIN ADME%REACTOME%R-RNO-9754706.1 Atorvastatin ADME Slco2b1 Cyp3a9 Abcc2 Ugt1a2 Ugt1a3 Ugt1a5 Cyp3a18 Abcb1 Cyp3a1 Cyp3a62 Cyp3a2 Pon3 Pon1 Slco1b2 ALPHA-DEFENSINS%REACTOME%R-RNO-1462054.1 Alpha-defensins Defa Prss2 Prss3 Try10 Prss2l1 Prss1 Art1 Np4 Defa24 Try5 Defa9 LOC102554637 Defal1 Defa8 Cd4 Defa6 Defa3 Defa31 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223393 Catecholamine biosynthesis Ddc Pnmt Dbh Th VESICLE-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223127 Vesicle-mediated transport Ereg Btc Galnt1 Galnt2 Spta1 Sptb Sptbn1 Sptbn2 Hbegf Sptan1 Sptbn5 Sptbn4 Grb2 Vamp2 App Tgfa Areg Scarb1 Cd36 Tjp1 S100a9 Il7r Hmgb1-ps34 Egfr Chmp2b Chmp3 Hmgb1l2 Hmgb1l1 Kif4b Chmp7 Ap2s1 Chmp6 Kif4a Vps4a Chmp4c Dnm3 Ap2a2 Chmp4bl1 Ap2a1 Ap2b1 Sh3gl2 Alpi Cyth2 Cyth3 Cyth4 Vps36 Cyth1 Slc18a3 Bnip1 Egf Vps25 Vps28 Bin1 Hpx Synj1 Bloc1s3 Kif18b Bloc1s4 Kif19 Bloc1s6 Kif26b Snf8 Kifc1 Snap29 Kifc2 Snx18 Kif26a Ubap1 Ston1 Ston2 Eps15l1 Kif11 ENSRNOG00000062839 Kif12 Tor1a Tor1b Kif15 Nbas Rab36 Kif5a Hp Kif5b Rab3il1 Tpd52 Kif21a Madd Scarb2 Kif1c Akt3 Ldlr Akt2 Snapin Kif21b Akt1 Cd163 Kif13b Cops3 Kif1a Sbf2 Cops6 Kif1b Sbf1 Optn Cops8 Kif6 Rab11b Aak1 Rab11a Synj2 Rab31 Tbc1d8b Rab35 Syt11 Tf Kif9 Rab38 Ambp Sh3gl3 Tsc2 Sh3kbp1 Tsc1 Tfrc Rab3gap2 Tpd52l1 Rab3gap1 Vps4b Dennd1a Dtnbp1 Kif22 Dnajc6 Clvs1 Rab1b Sh3gl1 Kif23 Dnase2 Fnbp1l Ulk1 Clvs2 Dennd1b Rint1 Kif28 Trappc2l Pik3c2a Fth1-ps5 Kif27 Ap4b1 Dennd1c Bicd2 Ap1b1 Kif16b Chmp2a Bicd1 Rin3 Kif20a Gabarap Klc1 Ap1m2 Agpat3 Vamp7 Fcho1 Rin1 Kif20b Bloc1s1 Fcho2 Rin2 Ap1m1 Pafah1b3 Mon1b Kifap3 Vamp8 Pafah1b2 Dennd6a Ap4s1 Fth1 Mon1a Ap1s3 Klc4 Mvb12a Dennd6b Ap1s2 Rab5a Mvb12b Rab4a Klc3 Necap2 Txndc5 Trappc10 Klc2 Necap1 Ap1g2 Vps37a Ap1g1 Rabgap1 Rab33b Vps37b Ap4m1 Rab33a Vps37c Kif3b Hspa8 Tbc1d2 Vps37d Ap4e1 Hps1 Hip1r Tbc1d7 Agfg1 Kif3c Gabarapl2 Vps45 Snx2 Snx9 Ccz1 Hps4 Snx5 Trappc12 Pum1 Trappc11 Cops7a Trappc13 Cops7b Rab3a Hip1 Rinl Tsg101 Gapvd1 Ftl1 Als2cl Gak Gdi1 Stx18 Rabgef1 Yipf6 Gdi2 Stab1 Chm Pla2g6 Rab7a Pacsin1 Rab7b Pacsin3 Pacsin2 Dennd4c Sort1 Dennd4a Ap3b1 Dennd4b Sh3d19 Ywhae Rab27a Grk3 Rab39a Amph Tbc1d14 Snap91 Rab27b Syt2 Tbc1d13 Syt9 Tbc1d16 Acbd3 Tbc1d15 Syt8 Tbc1d17 Use1 Trappc6b Akp3 Trappc6a Alpp Trappc9 Alpg Trappc8 Ubqln2 Tbc1d10c Chmp5 Trappc5 Ubqln1 Trappc4 Epn2 Trappc3 Epn1 Dennd5a Reps1 Trappc2 Reps2 Tbc1d10b Trappc1 Rab6b Tbc1d10a Rab6a Rab5c Rab5b Dennd5b Stx4 Als2 Golga4 Rab3ip Sytl1 Rab43 Tbc1d25 Tmf1 Tbc1d24 Sys1 Arf6 Golga1 Map1lc3b Vps51 Rab21 Vps52 Chml Vps54 Arl1 Rab9a Gcc2 Rab9b Gcc1 Dennd2a Rab1A Usp6nl Stx6 Dennd2c Ric1 Ttgn1 Rab10 Igf2r Scoc Rab13 M6pr Rab12 Vti1a Rab14 Vamp3 Rab18 Vamp4 Rab8b Stx16 Rab8a Arfip2 Rgp1 Rhobtb3 Ankrd27 Rabepk Dennd3 Arfrp1 Snap23 Slc2a8 Src Gria1 Msr1 Calr Arrb2 Arrb1 Cd3g Cd3d Cd4 Sparc Ctsz Jchain Pip5k1c LOC120093819 Pafah1b1 Zw10 Apol7al1 Kif18a Apol2 Dync1h1 Apol7bl1 Dync1i2 Dync1i1 Cenpe Apol9a Sec13 Kif2a Kif2b Kif2c Dync1li2 Dync1li1 Dynll1 Dynll2 Wnt5a Alb Kif3a Itsn2 Dvl2 Fzd4 Apoa1 Sar1b Gps1 Apoe Apob Trip10 Lrp1 Lrp2 Cops4 Arpc3 Cops2 Arpc2 Cpd Arpc5 Arpc4 Picalm Eps15 Dnm2 Avpr2 Trip11 Actr2 Arpc1a Actr3 Gns Gja10 Gjc1 Gjd2 Gjd4 Gjb2 Gjd3 Gjb1 Gjc2 Gja3 Gjb4 Gjb3 Gja5 Gjb6 Gjb5 Gja4 Gja8 Racgap1 Ocrl Fnbp1 Rps27a Agtr1 Ldlrap1 Uba52 Avp Ubb Ubc Pla2g4a Stam Cftr Ins1 Cd55 Lman1 Scfd1 Actr1a Lman2 Ins2 Sec22a Dctn1 Tfg Dctn2 Cog1 Cog2 Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Adrb2 Cog6 Cog7 Nedd8 Cog8 Napa Nsf Napb Ank1 Grk2 Napg Sec23a Tmem115 Tacr1 Kdelr2 Kdelr3 Sec23ip Sec16b Hgs Sec16a Lman2l Copa Bet1l Cnih1 Gorasp1 Cnih3 Cnih2 Kdelr1 Arf4 Ctsc Arf3 Arf1 Ppp6r3 Mia2 Mia3 Copb2 Stam2 Tmed10 Tmed9 Copb1 Cope Golgb1 Chrm2 Col7a1 Ppp6c Sec31b Sec31a F8 Stx17 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Hba1 Stx5 Hbb Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 Syt1 Hsp90b1 Prdx1 Itsn1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 Ap2m1 ENSRNOG00000070832 Gja1 ENSRNOG00000064041 Clta ENSRNOG00000064481 Cltb ENSRNOG00000065690 Myo6 ENSRNOG00000064085 ENSRNOG00000066904 Cltc ENSRNOG00000063713 Dab2 ENSRNOG00000062820 Dnm1 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Cbl Cops5 CARNITINE SHUTTLE%REACTOME DATABASE ID RELEASE 96%10222285 Carnitine shuttle Ppard Slc22a5 Prkag2 Cpt1a Mid1ip1 Prkaa2 Thrsp Cpt2 Cpt1b Slc25a20 Rxra Prkab2 FERTILIZATION%REACTOME%R-RNO-1187000.1 Fertilization Izumo1 Cd9 Hyal5 Catsperg Catsperd Catsper4 Catsper2 Catsperb Hvcn1 Catsper3 Catsper1 Kcnu1 Acr Izumo4 Izumo3 Izumo2 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 96%10224617 WNT5A-dependent internalization of FZD4 Cltb Dvl2 Cltc Arrb2 Prkcb Fzd4 Prkcg Wnt5a Ap2s1 Prkca Ap2a2 Ap2a1 Ap2b1 Ap2m1 Clta GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-RNO-381676.1 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Kcnb1 Kcns3 Kcnc2 Kcng2 Prkaca Prkacb Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Itpr3 Rapgef4 Itpr2 Rapgef3 Itpr1 Gcg Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Glp1r Gng11 Rap1a Gng10-ps1 Gnas ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-RNO-6807062.1 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) Srebf1 Nsdhl Dhcr24 Tm7sf2 Srebf2 Hsd17b7 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME%R-RNO-73943.1 Reversal of alkylation damage by DNA dioxygenases Alkbh5 Fto SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-RNO-111464.1 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Casp7 Diablol1 Xiap FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190374.1 FGFR1c and Klotho ligand binding and activation Kl Fgf23 Fgfr1 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 96%10224579 Formation of Senescence-Associated Heterochromatin Foci (SAHF) Rb1 Ep400 Asf1a Cabin1 Hira Ubn1 Hmga2 H1-1 Hmga1 H1-0 H1-5 H1-4 H4f3 Lmnb1 Tp53 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 96%10225361 Sensory perception of sweet, bitter, and umami (glutamate) taste Tas2r16 Tas2r13 Gnat3 Itpr3 Tas2r136 Tas2r140 Gnb1 Tas2r105 Tas2r107 Gnb3 Tas1r2 Tas2r119 Tas1r1 Tas2r120 Tas2r39 Tas1r3 Tas2r4 Tas2r38 Tas2r3 Tas2r40 Tas2r41 Tas2r7 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-RNO-212436.1 Generic Transcription Pathway Runx3 Ywhag Suz12 Cox5a Cox5b Zfp12 Eed Zfp13 Zfp950l16 Zfp282 Ttc5 Nr2c1 Kctd1 Rbbp4 Pou4f1 Rbbp7 Znf431l2 Pou4f2 Zfp668 Prkab2 Znf689 Prkab1 Zfp664 ENSRNOG00000065205 Zfp658 Zfp655 Znf624l Ube2d3 Zfp641 Zfp647 Znf667 Znf426 Cox4i1 Cox4i2 Nr2f6 Nr0b2 Nr0b1 Nr2f1 Nr2e3 Gadd45a Zfp212 Zfp213 Zfp455 LOC134478826 Mapk3 Rex2l4 Zfp445 Zfp688 Zfp950l5 Usp9x Map2k6 Lamtor3 Kat2a Lamtor2 Maml3 Rbpj Hdac2 Hdac5 Hdac4 Maml1 Mapk14 Hdac11 Maml2 Hdac10 Notch3 Hdac9 Hdac8 Cpap Mapk11 Ywhab Gpx2 Tgfb1 Wwox Furin Nr1h4 Ell Ccnk Tcea1 Ccnt2 Cdk13 Cdk12 Ssrp1 Eloa2l Eloa Txnrd1 Akt3 Akt2 Akt1 Gsr Ccne1 Ccne2 Steap3 Tsc2 Tsc1 Tfdp2 Tfdp1 Rbl1 Rpa1 Rpa2 Rpa3 Chm E2f4 E2f5 Cdkn1b Ywhae Rptor RragB Ppm1a Mtor Rheb Slc38a9 Lamtor5 Lamtor4 Rraga Lamtor1 Lbr Rragc Rragd Stk11 Mlst8 Brpf3 Rnf111 Src Blm Wrn Dna2 Mre11 Ube2i Eloc Kat5 Elob Atad2 Nbn Lhb Hus1 Cga Atrip Chek1 Chek2 Rad9a Rad9b Bard1 Top3a Rad17 Rfc5 Rfc3 Rfc4 Pcna Kmt5a Rfc2 Atm Atr Exo1 Sirt1 Rmi2 Rmi1 Brip1 Sp1 Sumo1 Rhno1 Rad50 Ehmt1 Ing5 Brd1 Topbp1 Rbbp8 Brca1 Rad1 Smyd2 Brpf1 Kat6a Meaf6 Med1 Sfn Plk3 Ccnc Prdm9 Pparg Rnf34 Phf20 Gls Nr2c2 Prmt5 Gpi Cdc25c Smurf1 Mdm4 Ywhaq Ywhah Ywhaz Zfp385a Pdpk1 Ctnnb1 Men1 Sirt3 Gls2 Arnt2 Tcf7 Arnt Tcf7l1 Tcf7l2 Zfp473 Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Smurf2 Polr2i Nelfe Polr2j Ctdp1 Lef1 Gtf2h2 Gtf2h1 Supt4h1 Gtf2f2 Gtf2f1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Banp Txn Cycsl2 Cycs Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 Psma1 Chd3 Rps27a Chd4 Psmd12 Psmd11 Psmd14 Psmd13 Mta2 Nr1h3 Mbd3 Nr1h2 Cbx3 Psmb5 Gatad2a Psmb4 Rxrb Gatad2b Psmb7 Rxra Psmb6 Ccnb1 Psmb1 Psmb3 Pgr Psmb2 Rxrg Uba52 Tbl1x Ube2d1 Psma7 Aurka Cited1 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Esr2 Psmc3 Cdk9 Hdac3 Ubb Tbl1xr1 Rara Ubc Foxo3 Psmb6l1 Npm1 Psmd7 Ppard Psmd6 Psmd8 Myc Psmd2 Mt-co3 Mt-co2 Ncor2 Psmd1 Adrm1 Cdk2 Cdk1 Rarg Mapk1 Mt-co1 Nr5a2 Notch4 Ar Ppp2cb Ppp2ca Foxo4 Zfp839 Ddit4 Higd1c Cited4 Cited2 Zfp819 Plk2 Igfbp3 Tmem219 Atxn3 Btg2 Zik1 Cdk5r1 Usp2 Zfp867 Zfp866 Zfp612 Zim1 Zfp617 Usp7 Zfp605 Zfp46 Zfp804b Sesn2 Zfp418l1 Ppp2r1b Sesn1 Ppp2r1a Smad2 Cnot11 Cdk5 Smad3 Sesn3 Smad4 Kdm5b Tfap2e Smad7 Cnot10 Npas4 Tp53rkb Tp53rka Zfp52 Znf354c Znf354b Znf354a Tnks1bp1 Zfp90 Zfp78 Zfp74 Maged1 LOC102546572 Zfp81 Skil Cox7a1 Cox7a2 Atp1b4 Zfp873l3 Zfp398 Cox7a2l Zfp386 Cnot6l Zfp764l1 Rffl Zfp133 Znf382 Cradd Pidd1 Znf394 Tpx2 Tp63 Esrra Tp53 Esrrb Zfp273l-ps1 Esrrg Zfp180 Zfp189 Parp1 Zfp184 Ccng1 Zfp169 H2ab2 Arid1a LOC102547287 Arid1b Zfp94l1 LOC108348267 Lmo2 Zfp455l1 Lmo3 Ccnh Zfp790 Zfp317 H2ac4 Serpinb13 Zfp799 Zfpm1 Zfp300 Nr1i2 Actl6a Zfp786 Actl6b Zfp788 Smarce1 Rsl1 Gata3 Zfp770 Gata1 Znf773 Gata2 Zfp775 Setd1b Yeats4 Setd1a Ring1 Wwtr1 Abl1 Zfp764 ENSRNOG00000066901 Zfp763 Tp73 Jmy Ccnd2 Zfp111 Phc2 Zfp113 Nr3c2 Cbx6 Zfp597 Nr3c1 Ccnd3 Znf750 Phc1 Tgif1 Cbx4 Tgif2 Cbfb Zfp599 Ccnd1 Nr1d2 Cbx2 Nr1d1 Vdr Esr1 Zfp583 Phc3 Zfp101 Kmt2d Dyrk2 Crebbp Ndufa4 L3mbtl2 Cdk7 Daxx Cdk6 Dek Kmt2a Trim33 Kmt2b Znf740 Kmt2c Zfp566 H2ac18 Ing2 Zfp324 Ppara Tcf3 Bax Sin3a LOC120095871 Nr1i3 Sin3b Zfp954 Csnk2a2 Zfp951 Ctsk Trim28 Zfp790l2 Ctsl Zfp710 Csnk2a1 Pcgf2 Zfp952 Bmi1 Thrb Znf18 Mnat1 Thra Zfp719 Pbrm1 Prdx2 Brd7 Prmt6 Prdx5 Hist1h2bq Zfp704 Prmt1 Zfp945 Smarcb1 Zfp703 Hdac1 Nr5a1 Zfp706 Wdr5 Zfp948 Ash2l ENSRNOG00000070049 Yaf2 Prdx1 L3mbtl1 Csnk2b Pax5 Tp53bp2 H2aj Taf9 Taf9b Nrbf2 Tfap2c Elf1 Nrbf2l1 Tfap2a Taf15 Elf2 Tead4 Tal1 Tfap2b Taf11 Zfp758 Smarca2 Taf10 Zscan25 Smarca4 Taf13 Zscan22 Foxp3 Taf12 H3-3b Tbp Zfp746 Yap1 Taf4b Krba1 Hist3h2ba Taf7l-ps1 Ep300 Pcgf6 Noc2l Rnf2 Tead3 ENSRNOG00000068602 Ski Itch Taf8 Tead2 Smarcd1 Taf7 Tcf12 Tigar Taf6 Zfp964 Smarcd3 Taf5 Pcgf5 Hipk1 Cox6a1 Smarcd2 Taf4 Cox6a2 Ptpn11 Taf2 Zfp286a H2bc18 Taf1 Rabggta Runx1 Kat2b Rabggtb Ppp1r13l H2az2 Ppp1r13b Rbbp5 Zfp119bl H2bc4 Max Hist1h4m H2bc1 Cox6c2 Pml Cnot3 Smarcc1 Cnot2 Hist1h2ai Cnot1 Nek4 Pip4k2b Cnot7 Pip4k2c Cnot6 Pip4k2a Cnot4 Rorc Cnot9 Rorb Foxo6 Cnot8 Sgk1 Cox6b1 Nr4a1 Cox6b2 Rictor Foxg1 Prr5 G6pdx Casp2 Mga Zfp37-ps1 Mapkap1 Tbx5 E2f6 E2f7 E2f8 Zfp275 Epc1 Zfp1 Zfp266 Zfp263 Nr6a1 Zfp496 Zfp808l3 Prkaa1 Pip4p1 Prkaa2 Zfp483 Cox8a Cox8c Zfp248 Nuak1 Hnf4a Cox7b Foxo1 Hnf4g Cox7c Zkscan8 Prkag3 Zkscan7 Prkag1 Zkscan1 Prkag2 Zkscan4 Zkscan5 Zkscan3 Bnip3l Nr4a3 Nr4a2 Mapkapk5 Ezh2 Zfp955a Zfp955b Bmal1 Nrif1 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 96%10225245 Activated NTRK2 signals through FRS2 and FRS3 Grb2 Sos1 Bdnf Frs2 Ntrk2 Ntf4 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222545 Release of apoptotic factors from the mitochondria Septin4 Bak1 Gsdme Gsdmd Cycsl2 Diablol1 Cycs Bax REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-RNO-3134975.1 Regulation of innate immune responses to cytosolic DNA Sting1 Rps27a Nlrp4 Dtx4 Uba52 Tbk1 Irf3 Trim32 Ubb Ddx41 Ubc Trim21 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-RNO-77075.1 RNA Pol II CTD phosphorylation and interaction with CE Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Cdk7 Gtf2h3 Gtf2h5 Ercc2 Ccnh Ercc3 Rngtt Polr2c Rnmt Polr2a Polr2b Mnat1 Polr2g Polr2h Polr2e Polr2f Polr2i P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10221973 p53-Dependent G1 S DNA damage checkpoint Psmb6 Zfp385a Psmb1 Psmb3 Psmb2 Phf20 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Chek2 Ubb Ubc Tp53 Psmb6l1 Cdkn1b Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Ccna1 Psmd1 Psma3 Adrm1 Ccna2 Cdk2 Atm Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Cop1 Psmd13 Mdm4 Psmb5 Psmb4 Psmb7 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224311 Synthesis of PIPs at the ER membrane Sacm1l Pi4ka Pi4k2b Sbf1 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%10224945 Synthesis of PIPs in the nucleus Pip4k2b Pip4k2c Pip4p1 Pip4k2a AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-352230.1 Amino acid transport across the plasma membrane Slc36a1 Slc3a2 Slc16a10 Slc1a5 Slc38a5 Slc38a4 Slc38a3 Slc1a4 Slc38a2 Slc38a1 Slc6a12 Slc25a29 Slc6a6 Slc7a11 Slc7a10 Slc6a19 Slc7a6 Slc43a1 Slc7a7 Slc43a2 Slc7a5 Slc6a15 Slc7a3 Slc7a8 Slc3a1 Slc7a1 Slc6a14 Slc7a9 Slc36a4 Slc6a20 Slc36a2 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 96%10222893 Signalling to ERKs Frs2 Ntrk1 Ngf Map2k2 Map2k1 Shc3 Shc1 Shc2 Mapkapk3 Mapk14 Braf Mapkapk2 Mapk3 Crkl Rapgef1 Nras Mapk1 Ralgds Grb2 Kras Rap1a Sos1 Hras Mapk11 Ywhab Crk Kidins220 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10221939 Lagging Strand Synthesis Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Rpa1 Rpa2 Rpa3 Lig1 Dna2 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222593 Activation of BID and translocation to mitochondria Casp8 Nmt1 Gzmb Bid CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 96%10223317 Caspase-mediated cleavage of cytoskeletal proteins Plec Casp8 Casp3 Casp7 Mapt Gsn Casp6 Gas2 Vim Sh3glb2 Sptan1 Add1 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 96%10223271 Extra-nuclear estrogen signaling Ereg Esr1 Pdpk1 Btc Gnai2 Gnai1 Gnai3 Egf Calm3 S1pr3 Prmt1 Creb1 Pik3ca Shc1 Gnat3 Cav1 Akt3 Ptk2 Hbegf Akt2 Akt1 Pik3r1 Src Hsp90aa1 Nras Pik3r2 Pik3r3 Kras Uhmk1 Hras Tgfa Areg Sphk1 Zdhhc7 Xpo1 Strn Prkcz Cav2 Esr2 Igf1r Foxo3 Mmp7 Mmp2 Mmp3 Cdkn1b Zdhhc21 Egfr Mmp9 Mapk1 Nos3 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME%R-RNO-8941855.1 RUNX3 regulates CDKN1A transcription Runx3 Smad3 Smad4 Tp53 Tgfb1 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222601 Activation of BIM and translocation to mitochondria Dynll1 Bcl2l11 Mapk8 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%R-RNO-2029485.1 Role of phospholipids in phagocytosis Plcg1 Prkcd Pld4 Pld2 Plpp4 Plpp5 Pld3 Pik3ca Pik3r1 Pik3cb Pik3r2 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Cd3g ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Plcg2 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 Pla2g6 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 Prkce Pld1 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 96%10223077 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes Ccne1 Ccne2 Rb1 Cdk2 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-RNO-3232142.1 SUMOylation of ubiquitinylation proteins Vhl Nup133 Nup210 Nup155 Pias4 Nup153 Ube2i Trim27 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Pias1 Nup62 Pias2 Nup43 Nup88 Aaas Ranbp2 Sumo1 Nup214 Pml CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 96%10223019 Conjugation of phenylacetate with glutamine Acsm2 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME DATABASE ID RELEASE 96%10222791 MyD88-independent TLR4 cascade Ppp2cb Ppp2ca Ube2d3 Ppp2r5d Ube2d2 Creb1 Ppp2r1b Ppp2r1a Mapk3 Ripk3 Rps6ka5 Ripk1 Fadd Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Rps6ka1 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Tbk1 Jun Irf3 Mapkapk2 Irak2 Irak1 Ager Nfkbia Ikbke Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Birc2 Optn Rps27a Ptpn11 Skp1 Uba52 Ube2d1 Btrc Ubb Ubc Cul1 Mapk1 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-RNO-2168880.1 Scavenging of heme from plasma Jchain Hpx Alb Hp Cd163 Apoa1 LOC120093819 Ambp Lrp1 Apol7al1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 Apol2 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 Apol7bl1 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 Hba1 ENSRNOG00000071049 Hbb AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 Apol9a ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10222169 RNA Polymerase I Transcription Cdk7 Rbbp4 Rbbp7 H2ac18 Mnat1 Hist1h2bq Hdac1 H2aj Tbp Polr1b H3-3b Mapk3 Polr1a Polr1f Hist3h2ba Polr1g Polr1e Polr1h ENSRNOG00000068602 Chd3 Chd4 Taf1d Rrn3 Mbd2 Taf1a Taf1c Taf1b Mta1 H2bc18 Mta2 Polr2h Mta3 Mbd3 H2az2 Polr2e Cbx3 Polr2f H2bc4 Ercc6 Hist1h4m Ubtf H2bc1 Gatad2a Gatad2b Hist1h2ai Gtf2h2 Gtf2h1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Cavin1 Ttf1 Polr1c Hdac2 H2ab2 Ccnh H2ac4 ENSRNOG00000066901 ACTIVATION OF SMO%REACTOME%R-RNO-5635838.1 Activation of SMO Grk2 Smo Csnk1a1 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%10225215 LXR-mediated signaling Abca1 Tbl1x Ncor2 Hdac3 Nr1h3 Nr1h2 Tbl1xr1 Gps2 Ep300 Rxrb Rxra OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%10222861 Oxidative Stress Induced Senescence Phc1 Suz12 Cbx4 Eed Cbx2 Phc3 Cdk6 Kdm6b Rbbp4 Rbbp7 H2ac18 Bmi1 Hist1h2bq Map3k5 Tnik H2aj Mink1 Map4k4 H3-3b Mapk3 Hist3h2ba Rnf2 ENSRNOG00000068602 Rps27a Cdkn2b Cdkn2d H2bc18 Mapk9 H2az2 H2bc4 Hist1h4m Mapk8 H2bc1 Hist1h2ai Uba52 Fos Map2k7 Map2k6 Ubb Ubc Tp53 Txn Mapkapk3 Mapk14 H2ab2 Jun Mapkapk2 H2ac4 Map2k3 Mapk1 Mdm4 Ring1 Mapk10 Mapk11 ENSRNOG00000066901 Cdk4 Mapkapk5 Ezh2 Phc2 Cbx6 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 96%10225493 Formation of the dystrophin-glycoprotein complex (DGC) Megf11 Sntg2 Agrn Dtna Dtnb Sgcz Snta1 Sntb2 Sntb1 Drp2 Dag1 Sgce Sgcd Utrn Sgcb Sgca Lama4 Sspn Dmd Sgcg MITOTIC PROMETAPHASE%REACTOME%R-RNO-68877.1 Mitotic Prometaphase Ywhag Spdl1 Nup133 Actr1a Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Dctn1 Dctn2 Prkaca Ppp2r5d Akap9 Ofd1 Prkar2b Ppp2r1b Ppp2r1a Ncapd2 Ncapg Smc4 Ncaph Smc2 Eml4 Wapl Numa1 Pds5b Pds5a Cdca5 Ppp2r5b Ppp2r5a Csnk1d Ccp110 Ppp1cc Ppp2r5e Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Firrm Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Nme7 Cep152 Tuba4a Tubgcp2 Haus4 Haus5 Haus6 Pcnt Hdac8 Sfi1 Haus1 Tubgcp6 Tubgcp5 Tubgcp4 Tubgcp3 Cep250 Smc3 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Stag2 Ninl Stag1 Csnk2a2 Csnk2a1 Smc1a Csnk2b Hsp90aa1 Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Dync1h1 Ccnb1 Spc24 Spc25 Xpo1 Mad2l1 Nuf2 Cdca8 Incenp Bub1b Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Aurkb B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Nek2l1 Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Ywhae Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Cdk1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ccnb2 Ranbp2 Ckap5 Csnk1e CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-RNO-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) Ebp Dhcr24 Dhcr7 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693548.1 Sensing of DNA Double Strand Breaks Kpna2 Mre11 Kat5 Rad50 Nbn Atm ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%R-RNO-1237044.1 Erythrocytes take up carbon dioxide and release oxygen Cyb5r1 Slc4a1 Aqp1 Ca1 Ca2 Cyb5r4 Ca4 Cyb5r2 Hba1 Cyb5rl Hbb Rhag CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME DATABASE ID RELEASE 96%10223187 Cell death signalling via NRAGE, NRIF and NADE Itgb3bp Ngf Arhgef7 Tiam1 Mcf2l Tiam2 Rac1 Bcl2l11 Arhgef15 Arhgef17 Arhgef16 Sqstm1 Arhgef11 Arhgef10 Arhgef12 Ngef Arhgef19 Rps27a Vav3 Akap13 Vav1 Vav2 Sos1 Itsn1 Arhgef26 Arhgef25 Psenen Psen1 Psen2 Sos2 Kalrn Ncstn Mapk8 Aph1a Traf6 Bex3 Arhgef6 Aph1b Arhgef5 Arhgef4 Arhgef2 Uba52 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Casp3 Casp2 Plekhg5 Plekhg2 Ubb Net1 Arhgef10l Ubc Ywhae Rasgrf2 Ngfr Mcf2 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-RNO-8964539.1 Glutamate and glutamine metabolism Glul Got2 Rimkla Gls Rimklb Oat Pycr3 Pycr2 Pycr1 Glud1 Kyat1 Gls2 Aldh18a1 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 96%10224655 Release of Hh-Np from the secreting cell Dhh Ihh Gpc5 Shh Notum Disp2 Scube2 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-RNO-5419276.1 Mitochondrial translation termination Mtrf1l Mt-cyb Gfm2 Mrrf Mrps9 Mrps2 Mt-atp6 Mrps7 Mrps5 Mt-nd4l Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl48 Mt-atp8 Mtrf1 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 AC132020.1 Mrpl15 Mrpl16 Mrpl17 Kgd4 Mrpl18 Mrpl19 Gadd45gip1 Mt-co3 Mt-co2 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 Mt-co1 Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10223891 Other interleukin signaling Ptprz1 Il16 Txlna Csf1r Stx3 Stx1a Snap25 Csf1 Sdc1 Casp3 Vamp2 Cd4 Stxbp2 Stx4 Il34 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-RNO-1222556.1 ROS and RNS production in phagocytes Lpo Mpo Ncf1 Ncf2 Ncf4 Cyba Slc11a1 Nos2 Cybb Atp6v0b Atp6v0a4 Atp6v1g3 Atp6v0e2 Nos1 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Rac2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Nos3 Atp6v1d Hvcn1 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-RNO-9909649.1 Regulation of PD-L1(CD274) transcription Suz12 Hist1h2ai Eed Rbbp4 Kmt2a Rbbp7 Kmt2c H2ac18 Hist1h2bq Wdr5 Ash2l H2aj H2ab2 H3-3b Hist3h2ba H2ac4 ENSRNOG00000068602 H2bc18 ENSRNOG00000066901 H2az2 Rbbp5 H2bc4 Ezh2 Hist1h4m H2bc1 SIGNALING BY CSF3 (G-CSF)%REACTOME%R-RNO-9674555.1 Signaling by CSF3 (G-CSF) Jak2 Shc1 Uba52 Eloc Gab2 Ube2d1 Elob Syk Lyn Socs3 Rps27a Hck Grb2 Kras Csf3 Tyk2 Cul5 Ptpn11 Ube2d3 Ube2d2 Ubb Socs1 Ubc SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 96%10224405 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Cyp1a1 Ephx2 Cyp1a2 Cyp1b1 Cyp2j16 Cyp2c66 Cyp2j3 Cyp2c11 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%10222549 SMAC, XIAP-regulated apoptotic response Septin4 Casp3 Casp7 Diablol1 Xiap IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223931 Ionotropic activity of kainate receptors Grik5 Grik2 Grik1 Grik4 Calm3 Grik3 Ncald Dlg1 Dlg3 Dlg4 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME DATABASE ID RELEASE 96%10225227 Biosynthesis of DPAn-3-derived maresins Alox12 Alox5 HATS ACETYLATE HISTONES%REACTOME%R-RNO-3214847.1 HATs acetylate histones Ncoa2 Phf20 Hcfc1 Kat7 Kansl3 Kansl1 Rbbp7 Kansl2 Ing4 Ing5 Brd1 Pax3 Mcrs1 Brpf3 Hist1h2bq Ogt Wdr5 Hat1 Jade1 Jade2 Jade3 Brpf1 Kat6b Kat6a Hist3h2ba Meaf6 Msl2 Msl3 Msl1 H2bc18 Kat8 Atf2 ENSRNOG00000066901 H2bc4 Hist1h4m H2bc1 REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 96%10224609 Repression of WNT target genes Ctbp2 Lef1 Tle4 Ctbp1 Tcf7l1 Tle3 Tle2 Tcf7l2 Tle1 Tcf7 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 96%10222947 Cyclin A:Cdk2-associated events at S phase entry Ccnd1 Cdk7 Mnat1 Psma4 Ccna1 Psma3 Akt3 Ccna2 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Psmd13 Cdc25a Skp2 Skp1 Psmb5 Psmb4 Ptk6 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Cks1b Cables1 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Wee1 Fzr1 Ubb Ubc Psmb6l1 Cdkn1b Psmd7 Rb1 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Ccnh Cdk2 Cdc25b Cdk4 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-RNO-72702.1 Ribosomal scanning and start codon recognition Eif5 Rps14 Rps15 Rps16 Eif2s3 Rps17 Rps15a Rps18 Eif2s2 Rps19 Rps2 Eif2s1 Rps27 Rpsa Rps10 Rps11 Rps13 Rps4x-ps13 Rps3a Rps27l Rps9 Rps7 Uba52 Rps8 Rps5 Eif4h Rps26-ps13 Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Rps3 Rps25 Rps4x Rps26 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Eif1ax Eif4a2 Eif4a1 Fau Rps6 Eif4e TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 96%10221951 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Ccne1 Cdkn1b Ccne2 Ccna1 Ccna2 Cdk2 E2f7 E2f8 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%10223551 Transmission across Electrical Synapses Gja10 Gjc1 Gjd2 Panx2 Panx1 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 96%10221971 p53-Dependent G1 DNA Damage Response Psmb6 Zfp385a Psmb1 Psmb3 Psmb2 Phf20 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Chek2 Ubb Ubc Tp53 Psmb6l1 Cdkn1b Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Ccna1 Psmd1 Psma3 Adrm1 Ccna2 Cdk2 Atm Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Cop1 Psmd13 Mdm4 Psmb5 Psmb4 Psmb7 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 96%10222247 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Mtr Ywhag Frs2 Frs3 Acbd5 Sptbn1 Ptk2 Aldh3a2 Mapk3 Sptan1 Emd Grb2 Rbmx Sos1 Tra2b Usp9x Iqgap2 Ppp2r5b Ppp2r5a S100a9 Ppp1cc Abcd3 Ppp1cb Ppp2r5e Map3k11 Mapk14 Prkcb Rasgrf2 Mapk11 Ywhab Rasal2 Ncoa2 Csk Itgb1 Atp6ap1 Kif5a Kif5b Ccne1 Dock5 Dock6 Steap3 Dock3 Dock4 Dock7 Tfrc Dock8 Pik3c3 Klc1 Pik3r4 Klc4 Klc3 Klc2 Dbt Dock10 Dock11 Rab7a Ywhae Lamtor1 Lbr Kidins220 Als2 Gopc Rhoq Rab9a Rab9b Vamp3 Sh3rf1 Rhobtb3 Ckb Snap23 Pde5a Pak1 Pak2 Tpm4 Rhoa Ngef Mylk Dlg4 Ncf1 Zap70 Ncf2 Ncf4 Lck AABR07021573.2 Rhog Lrrc41 Rhob Pard6b Pard6a Rac2 Fermt2 Flna Cyba Cybb Dst Actn1 Pik3ca Arhgap32 Cav1 Farp2 Pik3r1 Pik3r2 Pik3r3 Pafah1b1 Zw10 Knl1 Ska2 Ska1 Zwint Sfn Rps27 Rcc2 Kif18a Nudc Vhl Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Rbbp6 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Rhot2 Cenpe Mfn1 Clasp1 Mfn2 Clasp2 Rangap1 Trak1 Myo19 Nup37 Clip1 Trak2 Sgo2 Sgo1 Nup107 Cdc25c Sec13 Kif2a Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Ywhaq Ywhah Birc5 Aaas Ercc6l Ranbp2 Ckap5 Ywhaz Spdl1 Nup133 Bub1 Itgb3bp Hmox2 Zwilch Pdpk1 Ctnnb1 Men1 Garre1 Shmt2 AABR07032856.1 Osbpl11 Nisch Uaca Nckap1l Wipf3 Wipf1 Itsn2 Dvl1 Mrtfa Dvl2 Stmn2 Dvl3 Scrib Jag1 Fam83b Fam91a1 Mtmr1 Nox3 Nox1 Flot2 Samm50 Flot1 Fam169a Amigo2 Noxa1 Baiap2l2 Rapgef1 Baiap2l1 Letm1 Golga3 Gps1 Fgd5 Taok3 Ralgapa1 Cdc37 Chn2 Esyt1 Trip10 Wwp2 Fam135a Abi2 Abi1 Wdr11 Tuba1b Msi2 Ppp1r12b Stip1 Cpsf7 Ppp1r12a Phip Akap12 Stk38 Vrk2 Ppp1r14a Abl2 Slc1a5 Lin7b Cops4 S100a8 Arpc3 Cops2 Arpc2 Srgap1 Ubxn11 Arhgap45 Slk Cpd Cdh1 Arpc5 Cavin1 Daam1 Ctnna1 Arpc4 Pgrmc2 Picalm Tex2 Brk1 Bcr Ndufs3 Arhgap6 Jup Dsp Arhgap5 Arhgap15 Arhgap4 Arhgap17 Dsg1 Sowahc Htr7 Arhgap1 Dsg2 Stom Evl Arap1 Rhobtb2 Arap3 Rhobtb1 Arap2 Arhgap25 Arhgap9 Srf Arhgap8 Arhgap27 Mcam Slitrk5 Slitrk3 Pld1 Arhgap33 Ccdc115 Wasf3 Rtkn Wasf2 Rhpn1 Hsp90ab1 Wasf1 Rhpn2 Stk10 Plekhg1 Ralbp1 Stard8 Prc1 Maco1 Rnf20 Ddrgk1 Cct6a Faf2 Cdc42bpa Arhgdib Gmip Cdc42bpb Slc4a7 Anln Arhgap10 Arpc1b Actr2 Iqgap3 Arpc1a Diaph3 Actr3 Diaph1 Arhgap19 Btk Arhgap18 Pfn1 Depdc1b Senp1 Cit Pfn2 Vangl2 Fam13a Arhgef28 Twf1 Epsti1 C1qbp Arhgap22 Cpne8 Arhgap21 Nckap1 Arhgap20 Nipsnap2 Arhgap26 Ankle2 Arhgap24 Cyfip2 Arhgap23 Cyfip1 Arhgap29 Rhoh Arhgap28 Rhof Rhoc Ophn1 Rhoj Stbd1 Rac3 Dock2 Def6 Kif14 Vapb Rhou Pcdh7 Fam13b Scai Myo9b Nckipsd Emc3 Arhgap11a Cct7 Pak5 Myo9a Arhgap31 Ccdc88a Arhgap30 Tmem59 Prex2 Mtx1 Noxo1 Actc1 Arhgap35 Mpp7 Ankrd26 Fmnl3 Tagap Srgap2 Racgap1 Srgap3 Plekhg6 Ocrl Tmod3 Tmem87a Plekhg3 Cdc42ep1 Bcap31 Cdc42ep4 Ktn1 Plxna1 Farp1 Syde1 Dlc1 Syde2 Pld2 Stard13 Arhgap40 Elmo2 Pkn2 Rras2 Rock2 Arhgef7 Dnmbp Rock1 Nsfl1c Pkn1 Ccdc187 Arhgap44 Plxnd1 Arhgap42 Basp1 Tjp2 Ddx4 Spata13 Kdm4c Nck2 Rnd2 Rac1 Rnd3 Pak3 Rnd1 Git1 Swap70 Arhgdig Baiap2 Kctd13 Fnbp1 Bltp3b Spen Hsp90aa1 Armcx3 Ndufa5 Add3 Tor1aip1 Sema4f Lmnb1 Ptpn13 Fmnl2 Fmnl1 Sh3bp1 Prag1 Limk1 Vim Cdc20 Hspe1 Kdm1a Tnfaip1 Mad2l1 Bub1b Nck1 Aurkb Actb Prkcz Plk1 Mapk1 Stam Ar Mcf2 Arhgdia Cftr Lman1 Scfd1 Ppp2cb Grb7 Ppp2ca Prkcd Arfgap3 Prkca Calm3 Ppp2r5d Hgs Ppp2r1b Ppp2r1a Stam2 Muc13 Peak1 Cep97 Wdr6 Txnl1 Pak6 Rhov Pak4 Ccp110 Git2 Arhgap12 Epha2 Zfp512b Dlg5 Stx5 Ykt6 Ckap4 H2ab2 H2ac4 Arl13b Abl1 ENSRNOG00000066901 Cct2 H2ac18 Hist1h2bq Actg1 Ptk2b H2aj Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 H3-3b Arhgef16 Hist3h2ba Arhgef11 Arhgef10 Arhgef12 ENSRNOG00000068602 Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 H2bc18 H2az2 Sos2 Kalrn H2bc4 Hist1h4m H2bc1 Arhgef6 Hist1h2ai Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Abr Fgd3 Arhgef39 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Gja1 Ddx39b Myo6 Cltc Vcp Hnrnpc Cdc42ep2 Cdc42ep3 Cdc42 Cul3 Srrm1 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 96%10224429 Anchoring fibril formation Bmp1 Col7a1 Tll2 Tll1 RHOBTB3 ATPASE CYCLE%REACTOME%R-RNO-9706019.1 RHOBTB3 ATPase cycle Hgs Vhl Ccne1 Rhobtb3 Lrrc41 Rab9a Rab9b Htr7 Cul3 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 96%10222687 Dissolution of Fibrin Clot S100a10 Serpinb2 Serpine2 Plat Anxa2 Plau Serpinb6a Serpine1 Serpinf2 Hrg Plg Plaur THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME DATABASE ID RELEASE 96%10222211 The canonical retinoid cycle in rods (twilight vision) Rho Ttr Rdh11 Rdh10 Rdh12 Cyp4v2 Stra6 Rpe65 Rbp4 Rbp3 Myo7a Rlbp1 Rbp1 Lrat EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 96%10224877 Events associated with phagocytolytic activity of PMN cells Lpo Mpo RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%R-RNO-110328.1 Recognition and association of DNA glycosylase with site containing an affected pyrimidine Neil1 INTERLEUKIN-1 PROCESSING%REACTOME%R-RNO-448706.1 Interleukin-1 processing Il18 Casp1 Il1a Ctsg Nfkb2 Gsdmd Il1b Nfkb1 Rela ALPHA-OXIDATION OF PHYTANATE%REACTOME DATABASE ID RELEASE 96%10223633 Alpha-oxidation of phytanate Pecr Phyh Slc27a2 Aldh3a2 Hacl1 RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225181 RHOU GTPase cycle Arhgef6 Wdr6 Txnl1 Pak4 Rhou Git2 Epha2 Dlg5 Arhgap31 Nck1 Arhgap30 Srgap2 Dst Ptk2b Arhgef7 Itsn2 Hgs Myo6 Cltc Nck2 Pak1 Pak3 Git1 Sptbn1 Pak2 Pard6a Sptan1 Pik3r1 Stam2 Grb2 Pik3r2 Depdc1b Wwp2 Stam Cdc42 Usp9x Peak1 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-210500.1 Glutamate Neurotransmitter Release Cycle Rims1 Slc17a7 Tspoap1 Syt1 Stx1a Ppfia3 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Gls Unc13b Snap25 Cplx1 Slc1a1 Arl6ip5 Slc38a2 Slc1a7 Vamp2 Rab3a Slc1a6 Gls2 Slc1a3 Slc1a2 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-RNO-418555.1 G alpha (s) signalling events Pde11a Arrb2 Pde4a Arrb1 Prkaca Prkacb Adrb2 Prkar1a Pde3a Prkar1b Pde7a Grk5 Itgb1 Grk6 Pde2a Pde8a Grk2 Pde8b Pde4c Pde4d Pde3b Shc1 Grk3 Prkar2a Prkar2b Pde10a Pde1b Pde1a RHO GTPASE EFFECTORS%REACTOME%R-RNO-195258.1 RHO GTPase Effectors Ywhag Spdl1 Nup133 Bub1 Itgb3bp Zwilch Pdpk1 Ctnnb1 Men1 Nckap1l Wipf3 Wipf1 Dvl1 Mrtfa Dvl2 Dvl3 Nox3 Nox1 Ptk2 Mapk3 Noxa1 Grb2 Abi2 Abi1 Iqgap2 Ppp1r12b Ppp2r5b Ppp2r5a Ppp1r12a Ppp1r14a Lin7b S100a9 Ppp1cc Ppp1cb S100a8 Arpc3 Arpc2 Ppp2r5e Cdh1 Arpc5 Daam1 Ctnna1 Arpc4 Brk1 Evl Srf Rtkn Wasf3 Rhpn1 Wasf2 Rhpn2 Wasf1 Mapk14 Prkcb Prc1 Arpc1b Actr2 Iqgap3 Arpc1a Diaph3 Actr3 Diaph1 Btk Pfn1 Pfn2 Cit Mapk11 Nckap1 Ywhab Cyfip2 Cyfip1 Rhoc Kif14 Ncoa2 Scai Nckipsd Noxo1 Fmnl3 Srgap2 Ktn1 Pkn2 Rock2 Rock1 Pkn1 Kdm4c Rac1 Kif5a Pak3 Kif5b Baiap2 Fmnl2 Fmnl1 Limk1 Cdc20 Kdm1a Pik3c3 Klc1 Pik3r4 Mad2l1 Klc4 Klc3 Bub1b Klc2 Nck1 Aurkb Actb Prkcz Ywhae Plk1 Mapk1 Ar Cftr Ppp2cb Gopc Ppp2ca Rhoq Prkcd Prkca Calm3 Ppp2r5d Pak1 Ppp2r1b Ppp2r1a Pak2 Rhoa Mylk Dlg4 Ncf1 Ncf2 Ncf4 Rhog H2ab2 Rhob Rac2 H2ac4 Flna Abl1 ENSRNOG00000066901 H2ac18 Cyba Cybb Hist1h2bq Actg1 H2aj H3-3b Hist3h2ba ENSRNOG00000068602 Pafah1b1 Zw10 Knl1 H2bc18 Ska2 Ska1 Zwint H2az2 Sfn Rps27 H2bc4 Hist1h4m Rcc2 H2bc1 Kif18a Nudc Dync1h1 Hist1h2ai Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Sgo2 Sgo1 Nup107 Cdc25c Sec13 Kif2a Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Ywhaq Ywhah Cdc42 Birc5 Ercc6l Ranbp2 Ckap5 Ywhaz CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 96%10224557 Cellular response to heat stress Nup133 Nup210 Nup155 Nup153 Gsk3b Crebbp Hspa5 Hsf1 Hspa1b Hspa1a Mapk3 Ep300 Hsp90aa1 Eef1a1 Camk2g Camk2d Camk2b Camk2a Hspa8 Rpa1 Nup93 Rpa2 Nup50 Hsph1 Dnajc2 Rpa3 Cryab Hspa1l Nup35 Hikeshi Hspa14 Nup54 Hspa13 Nup98 Rps19bp1 Hsbp1 St13 Ywhae Nup58 Hspa12b Rptor Fkbp4 Hspa12a Hspa2 Nup37 Hsp90ab1 Bag5 Pom121 Bag3 Ptges3 Bag2 Nup205 Bag1 Mapkapk2 Mtor Nup107 Hspb8 Sec13 Dnajb6 Hspa9 Nup188 Hspa4 Tpr Nup160 Vcp Rae1 Mapk1 Ndc1 Akt1s1 Sirt1 Nup85 Nup42 Nup62 Nup43 Nup88 Dnajb1 Aaas Mlst8 Ranbp2 Nup214 SIGNALING BY MET%REACTOME DATABASE ID RELEASE 96%10224913 Signaling by MET Arf6 Stat3 Met Ranbp9 Itgb1 Itga3 Usp8 Hgs Megf11 Pik3ca Shc1 Rac1 Ptk2 Crkl Pik3r1 Src Rapgef1 Nras Rps27a Stam2 Grb2 Lama4 Rap1a Kras Rap1b Sos1 Sh3gl3 Hras Sh3kbp1 Dock7 Ptpn11 Sh3gl1 Gab1 Uba52 Rab4a Eps15 Ptpn2 Ubb Ubc Hgf Itga2 Ptpn1 Lrig1 Tns4 Tns3 Cbl Hgfac Hpn Rab4b Gga3 Spint2 Spint1 Ranbp10 Sh3gl2 Stam Crk TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 96%10224897 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cnot3 Cnot2 Npm1 Cnot1 Cnot7 Cnot6 Cnot4 Cnot9 Cnot11 Cdc25c Cnot8 Cnot10 Cnot6l Plk2 Tnks1bp1 Btg2 Cpap Plk3 PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222079 Propionyl-CoA catabolism Pcca Pccb Mmut Mmaa TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%10222279 Transport of small molecules Slco2b1 Slco2a1 Phb1 Slco4c1 SLC16A2 Slco1c1 Os9 Rnf5 Hmox1 Sel1l Magt1 Cygb Mb Ngb Slc15a1 Ctns Slc15a3 Slc15a4 Pex3 Abcd1 Scarb1 Abcd2 Slc26a2 Abcd3 Slc26a1 Slc35b3 Slc35b2 Slc26a11 Myo5b Aqp4 Aqp3 Aqp2 Pex19 Slc22a3 Arl2 Ap2s1 Ap2a2 Ap2a1 Ap2b1 Bmp1 Zdhhc8 Furin Abcc3 Apoc1 Apoc4 Atp6v0b Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v1c2 Slc13a4 Atp6v0a1 Slc13a1 Atp6v1c1 Atp6v0c Atp6ap1 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Ldlr Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Rab11a Atp6v1d Hfe Tf Steap3 Steap4 Mcoln1 Tfrc Tfr2 Fth1-ps5 Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc67a1 Fth1 Slc44a2 Slc4a2 Slc4a4 Slc4a3 Slc4a5 Slc4a8 Slc33a1 Slc4a9 Slc10a6 Slc22a8 Slc22a7 Slc12a1 Slc45a3 Slc12a4 Slc35d1 Slc12a5 Slc22a6 Slc12a2 Lcn12 Slc12a3 Slc22a5 Slc12a6 Slc22a4 Slc12a7 Slc5a1 Slc5a3 Slc34a3 Ftl1 Slc5a2 Slc5a4 Slc5a7 Slc35c1 Slc11a2 Apod Abcc4 Slc27a1 Arl2bp Slc25a26 Slc25a29 Slc39a4 Slc39a3 Slc39a2 Slc39a1 Emb Slc39a8 Slc39a7 Slc39a6 Slc16a7 Slc2a13 Slc6a6 Slc2a12 Slc16a3 Slc2a10 Slc16a8 Slc31a1 Fgf21 Slc16a1 Slc28a3 Slc28a2 Slc28a1 Slc20a2 Slc20a1 Slc43a1 Slc43a2 Slc17a1 Slc7a3 Slc7a1 Mfsd4b4 Slc29a3 Slc29a2 Slc29a1 Slc29a4 Slc30a10 Slc25a1 Slc40a1 Slc14a2 Slc14a1 Slc26a6 Pcsk5 Slc26a4 Slc26a3 Slc26a9 Slc8b1 Slc26a7 Slc41a2 Lcn9 Slc41a1 Slc1a1 Slc38a5 Slc38a4 Slc38a3 Slc1a4 Slc38a2 Slc1a7 Slc1a6 Slc9a1 Slc9a4 Slc9a5 Slc9a2 Slc9a3 Slc9a8 Slc6a12 Slc9a9 Add1 Slc9a6 Slc9a7 Slc27a4 Slc27a6 Slc35b4 Slc5a10 Slc5a12 Slc5a11 Slc2a2 Slc2a4 Atp2a1 Slc2a8 Slc2a7 Atp2a3 Slc2a9 Atp2a2 Slc35a3 Slc35a2 Slc39a14 Slc50a1 Kcnj11 Trpc7 Slc24a5 Abcc9 Trpc3 Slc47a1 Slc24a4 Slc24a3 Slc24a2 Atp2b1 Slc24a1 Camk2g Atp2b4 Ahcyl2 Camk2d Atp2b3 Slc22a15 Camk2b Vegp2 Vegp1 Slc22a12 Slc22a16 Slc3a1 Slc13a5 Cyb5r4 Sri Slc36a4 Cyb5r2 Camk2a Slc13a3 Cyb5rl Slc36a2 Slc36a1 Wwp1 Slc3a2 Slc13a2 Slc4a10 Atp1b1 Slc16a10 Heph Atp1b3 Slc25a5 Atp1b2 Slc25a4 Ryr2 Ryr1 Fkbp1b Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Clic2 Trdn Pln Asph Trpc1 Angptl4 Raf1 Mylip Ano6 Ano5 Slc7a11 Slc7a10 Slc7a6 Afg3l2 Slc7a7 Clcn2 Clcn1 Slc7a5 Cand1 Slc7a8 Parl Slc7a9 Nipal4 Nipal2 Nipal3 Nipal1 Lipa Slc8a1 Lipc Slc8a2 Pheta2 Ano10 Ttyh3 Slc8a3 Ttyh1 Ttyh2 Dmtn Slc17a3 Nipa1 Nipa2 Fbxl5 Pcsk6 Trpc4ap Esyt3 Esyt2 Pmpcb Pmpca Aqp12a Rhcg Rhbg Atp9b Atp9a Best4 Ireb2 Pip Best1 Best3 Mcu Best2 Nceh1 Atp7b Clca1 Clca2 Clca4 Cyb5r1 Trpc5 Trpc4 Apobr Stoml3 Unc80 Npc2 Npc1 Atp2c1 Atp2c2 Scnn1a Lmf1 Scnn1b Lmf2 Unc79 Apoa5 Scnn1g Lrrk1 Trpa1 Slc5a5 Maip1 Tpcn1 Bsnd GLTP Aqp9 Eif2s3 Aqp8 Aqp7 Aqp5 Pcsk9 Eif2s2 Atp4a Atp4b Eif2s1 Mip Ankh Cp Mrs2 Plekha8 Trpm2 Trpm1 Azgp1 Soat2 Soat1 Ano9 Ano8 Trpm8 Trpm7 Ano7 Micu2 Micu3 Trpm4 Ano4 Trpm3 Micu1 Ano3 Trpm6 Ano2 Ano1 Vldlr Sgk3 Sgk2 Slc66a1 Mcub Asic5 Angptl8 Asic4 Atp10a Atp10b Slc38a1 Atp10d Slc1a3 Asic1 Slc1a2 Asic3 Asic2 Angptl3 Cybrd1 Atp11b Atp11a Atp11c Atp13a1 Atp8b2 Atp8b1 Atp8b4 Atp8b3 Ftmt Atp13a2 Atp13a4 Atp13a5 Hdlbp Atp12a Trpv5 Trpv4 Trpv6 Trpv1 Trpv3 Trpv2 Nalcn Tsc22d3 Clcnkb Clcnka Aqp11 Spg7 Add2 Mcoln3 Slc22a17 Mcoln2 Clcn6 Clcn7 Clcn4 Clcn5 Hmox2 Lrrc8e Cptp Abcg2 Lrrc8a Abcc1 Lrrc8b Abcc2 Lrrc8c Cln3 Lrrc8d Aqp10 Abcb1 Alb Mttp Apoc2 Apoa1 Apoc3 Apoa2 Abcf1 Abcb6 Sar1b Abcb7 Apoe Abcb4 Apoa4 Abcb5 P4hb Abcb8 Apob Abcb9 Esyt1 Abcg4 Abcg8 Abcg5 Abcc5 Abcc6 Abca12 Abcc10 Lpl Gpihbp1 Abca2 Abca5 Abca6 Abca9 Abca7 Abca8 Slc1a5 Yme1l1 Stom Stoml2 Phb2 Avpr2 Slc4a7 Slc35d2 Bsg Psma4 Psma3 A2m Psma6 Psma5 Psma2 Psma1 Rps27a Add3 Psmd12 Psmd11 Psmd14 Psmd13 Nr1h3 Nr1h2 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ldlrap1 Psmb1 Psmb3 Psmb2 Uba52 Avp Psma7 Psmc5 Psmc2 Slc5a6 Psmc1 Slc5a8 Psmc4 Abca1 Psmc3 Cubn Ubb Slc46a1 Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Slc2a1 Psmd1 Slc2a3 Adrm1 Cul1 Amn Gng10-ps1 Cftr Prkaca Prkacb Prkar1a Nedd8 Lipg Prkar1b Pltp Calm3 Lcat Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Prkar2a Prkar2b Atp7a Gnb2 Arf1 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Slc22a2 Slc6a19 Slc6a5 Slc22a1 Slc32a1 Slc6a7 Slc6a15 Slc6a9 Slc6a14 Slc6a11 Gnas Slc6a13 Slc6a20 Slc25a18 Slc25a22 Slc6a2 Slc17a7 Slc6a1 Slc17a8 Slc6a4 Slc6a3 Slc17a6 Slc34a1 Ca1 Ca2 Ca4 Hba1 Hbb Rhag Slc34a2 Slc4a1 Aqp1 Slc11a1 Abca3 Lcn2 Slc30a5 Slc30a8 Aco1 Runx1 Slc25a10 Nek4 Sgk1 Slc17a5 Slc35a1 Ap2m1 Clta Cltc Rnf185 Derl3 Derl2 Slc25a11 Erlin2 Erlin1 Vcp Slc30a1 Tusc3 Slco3a1 Erlec1 Slco1a4 Slco4a1 Slco1b2 TGFBR3 PTM REGULATION%REACTOME DATABASE ID RELEASE 96%10225439 TGFBR3 PTM regulation Aph1b Mmp16 Timp2 Tgfbr3 Psenen Psen1 Psen2 Ncstn Mmp14 Aph1a Timp1 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%10224301 Resolution of Sister Chromatid Cohesion Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Wapl Pds5b Pds5a Cdca5 Ppp2r5b Ppp2r5a Ppp1cc Ppp2r5e Firrm Hdac8 Smc3 Stag2 Stag1 Smc1a Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Dync1h1 Ccnb1 Spc24 Spc25 Xpo1 Mad2l1 Nuf2 Cdca8 Incenp Bub1b Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Aurkb B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Cdk1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ccnb2 Ranbp2 Ckap5 STABILIZATION OF P53%REACTOME%R-RNO-69541.1 Stabilization of p53 Psmb6 Psmb1 Psmb3 Psmb2 Phf20 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Chek2 Ubb Ubc Tp53 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Atm Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Cop1 Psmd13 Mdm4 Psmb5 Psmb4 Psmb7 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856825.1 Cargo recognition for clathrin-mediated endocytosis Ereg Wnt5a Btc Ttgn1 Igf2r M6pr Vamp3 Adrb2 Vamp4 Nedd8 Grk2 Tacr1 Itsn2 Hgs Dvl2 Slc2a8 Fzd4 Hbegf Grb2 Stam2 Gps1 Apob Chrm2 Vamp2 Tgfa Areg Lrp2 Arrb2 Arrb1 Il7r Cops4 Cops2 Cd3g Picalm Eps15 Cd3d Cd4 Avpr2 Egfr Syt1 Ap2s1 Ap2a2 Ap2a1 Ap2b1 Sh3gl2 Slc18a3 Egf Ston1 Ston2 Eps15l1 Tor1a Tor1b Scarb2 Ldlr Cops3 Cops6 Cops8 Aak1 Rps27a Syt11 Tf Itsn1 Sh3gl3 Sh3kbp1 Tfrc Agtr1 Sh3gl1 Ldlrap1 Fcho1 Vamp7 Fcho2 Vamp8 Uba52 Necap2 Necap1 Avp Agfg1 Cops7a Cops7b Ubb Ubc Ap2m1 Clta Cltb Cltc Dab2 Grk3 Snap91 Syt2 Syt9 Syt8 Ubqln2 Cbl Ubqln1 Epn2 Epn1 Reps1 Reps2 Cops5 Stam Cftr PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-RNO-73817.1 Purine ribonucleoside monophosphate biosynthesis Adss2 Pfas Paics Gart Adss1 Gmps Impdh2 Atic Adsl Impdh1 Ppat CELL-CELL JUNCTION ORGANIZATION%REACTOME%R-RNO-421270.1 Cell-cell junction organization Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Xiap Src Fyn Ctbp1 Tyk2 Il6st Nfkb1 Ctsb Cbll1 Rela Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Pard3 Mogs Nectin1 Angptl4 Cdh9 Nectin2 Pvr Cdh8 Vcl Hdac2 Jak2 Nectin4 Cdh7 Cdh6 H2ab2 Cdh3 Cdh2 Twist1 Pard6b Il6 Pard6a Kmt5a H2ac4 Sec11c Amot Sec11a Il6r Prkcsh Sirt1 Pard6g Zmym2 Cadm3 Sp1 ENSRNOG00000066901 Cdh24 Cadm2 Cadm1 Rnf19b F11r Pomt1 Sdk1 Hace1 Dnttip1 Pomt2 Stat3 Furin Pcsk7 Pcsk6 Sdk2 Birc2 H2ac18 Adam19 Afdn Ctbp2 Csnk2a2 Ang2 Ctsl Zeb1 Csnk2a1 Zeb2 Cdh18 Cdh17 Cdh15 Hist1h2bq Cdh13 Cdh12 Hdac1 Cdh11 Cdh10 Ganab Csnk2b Mphosph8 H2aj Canx Tiam1 Arhgap32 Spcs3 Prkci Rac1 Spcs1 Spcs2 Psma4 Smarca4 Farp2 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Vav2 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Arhgef4 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Cdc42 Ezh2 Dad1 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-RNO-9958863.1 SLC-mediated transport of amino acids Slc36a1 Slc3a2 Slc16a10 Slc1a5 Slc1a1 Slc38a5 Slc38a4 Slc38a3 Slc1a4 Slc38a2 Slc1a7 Slc1a6 Slc38a1 Slc6a12 Slc1a3 Slc1a2 Slc25a29 Slc6a6 Slc7a11 Slc7a10 Slc6a19 Slc7a6 Slc43a1 Slc7a7 Slc43a2 Slc7a5 Slc6a15 Slc7a3 Slc7a8 Slc3a1 Slc7a1 Slc6a14 Slc7a9 Slc36a4 Slc6a20 Slc36a2 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223857 Hydroxycarboxylic acid-binding receptors Hcar1 Hcar2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 96%10221943 Removal of the Flap Intermediate Fen1 Pold2 Pold1 Pcna Pola2 Pola1 Pold4 Pold3 Prim2 Prim1 Rpa1 Rpa2 Rpa3 Dna2 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-RNO-9975921.1 Assembly of the 9+0 primary cilium Ywhag Actr1a Dctn1 Dctn2 Prkaca Cc2d2a Tmem67 C2cd3 Rab8a Mark4 Cep162 Rpgrip1l Septin2 Kif24 Ttbk2 Ift140 Tctn3 Fbf1 Tctn1 Kif3a Akap9 Tctn2 Iqcb1 B9d1 Cep89 Mks1 Ahi1 Ift52 Nphp4 Ttc21b Cep83 Ift57 Nphp1 Ift122 Ofd1 Sclt1 Tmem216 Wdr35 Prkar2b Dync2h1 Ppp2r1a Ift172 Wdr19 Arf4 Cep97 Csnk1d Ccp110 Gbf1 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Pcm1 Dynlrb2 Ssna1 Dynlrb1 Ift70b Tubg1 Ift81 Cep63 Dynlt2b Sstr3 Ift80 Cep152 Dynlt5 Tuba4a Dynlt2 Haus4 Haus5 Kif17 Haus6 Pcnt Trip11 Sfi1 Dync2i1 Haus1 Dync2li1 Dync2i2 Cluap1 Traf3ip1 Mkks Ift20 Unc119b Arl13b Cep250 Ift22 Pkd1 Cep290 Cep78 Ift27 Rp2 Cep76 Ift25 Asap1 Cep72 Ift56 Bbs9 Bbs7 Cep164 Cep70 Bbs5 Ift43 Cpap Bbs4 Tubb5 Cct3 Ift46 Plk4 Cct2 Ift74 Odf2 Bbs10 Ift70a2 Bbs12 Alms1 Thoc2l Cetn2 Cngb1 Exoc3 Cep135 Exoc4 Cep43 Exoc5 Cep41 Exoc6 Cep131 Exoc1 Tubb4b Exoc2 Tubb4a Exoc7 Ninl Exoc8 Tcp1 Inpp5e Arl6 Arl3 Cnga4 Cnga2 Bbip1 Cct8 Cct5 Cct4 Bbs2 Atat1 Pde6d Ttc8 Nphp3 Lztfl1 Mchr1 Hsp90aa1 Rab11a Pafah1b1 Dync1h1 Kifap3 Dync1i2 Kif3b Tnpo1 Kif3c B9d2 Nde1 Nek2l1 Rho Clasp1 Ywhae Plk1 Smo Cdk1 Mapre1 Dynll1 Dynll2 Ckap5 Csnk1e Rab3ip RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225345 RND2 GTPase cycle Nudc Wdr6 Txnl1 Kif14 Epha2 Frs2 Dlg5 Frs3 Ubxn11 Arhgap35 Ankrd26 Dst Arhgap5 Ktn1 Dsg1 Arhgap1 Nisch Ckap4 Plxnd1 Scrib Fam83b Rnd2 Cav1 Aldh3a2 Kctd13 Fnbp1 Pik3r1 Bltp3b Golga3 Pik3r2 Rbmx Depdc1b Ptpn13 Vangl2 Tfrc Muc13 Prag1 Kidins220 Tnfaip1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-RNO-936837.1 Ion transport by P-type ATPases Atp9b Atp9a Calm3 Atp7b Atp2a1 Atp2c1 Atp2c2 Atp2a3 Atp7a Atp2a2 Atp2b1 Camk2g Atp2b4 Camk2d Atp2b3 Camk2b Atp4a Atp4b Sri Camk2a Atp1b1 Atp1b3 Atp1b2 Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Pln Atp10a Atp10b Atp10d Atp11b Atp11a Atp11c Atp13a1 Atp8b2 Atp8b1 Atp8b4 Atp8b3 Atp13a2 Atp13a4 Atp13a5 Atp12a NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 96%10224487 Nuclear Envelope Breakdown Nup133 Ccnb1 Nup210 Nup155 Nup153 Vrk2 Prkca Nek9 Ctdnep1 Cnep1r1 Lpin3 Nup93 Lpin2 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Plk1 Nup205 Prkcb Nup107 Sec13 Nup188 Tpr Vrk1 Emd Cdk1 Nup160 Rae1 Lmna Ndc1 Lmnb1 Nup85 Nup42 Nup62 Ccnb2-ps2 Nup43 Nup88 Banf1 Aaas Ccnb2 Ranbp2 Nup214 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225195 Miro GTPase Cycle Rhot2 Mfn1 Mfn2 Trak1 Myo19 Trak2 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-RNO-162710.1 Synthesis of glycosylphosphatidylinositol (GPI) Pigb Dpm2 Piga Pigm Pigl Pigg Pigf Pigh Pign Pigq Pigp Pigw Pigv Pigx Pigc RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%10222173 RNA Polymerase I Promoter Escape Hist1h2ai Gtf2h2 Gtf2h1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 H2ac18 Polr1c Mnat1 Hist1h2bq H2aj H2ab2 Tbp Polr1b H3-3b Polr1a Hist3h2ba Ccnh Polr1f H2ac4 Polr1g Polr1e ENSRNOG00000068602 Polr1h Taf1d Rrn3 Taf1a Taf1c Taf1b H2bc18 Polr2h ENSRNOG00000066901 H2az2 Polr2e Cbx3 Polr2f H2bc4 Hist1h4m Ubtf H2bc1 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 96%10224981 PTK6 Regulates Proteins Involved in RNA Processing Sfpq Khdrbs1 Khdrbs3 Khdrbs2 Ptk6 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-RNO-5389840.1 Mitochondrial translation elongation Gfm1 Mrps9 Mrps2 Mrps7 Mrps5 Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl48 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 AC132020.1 Mrpl15 Mrpl16 Mrpl17 Kgd4 Mrpl18 Mrpl19 Gadd45gip1 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 96%10223873 Synthesis of GDP-mannose Gmppa Pmm2 Mpi Pmm1 TBC RABGAPS%REACTOME DATABASE ID RELEASE 96%10225009 TBC RABGAPs Sytl1 Gabarap Tbc1d25 Tbc1d24 Arf6 Map1lc3b Rab4a Rabgap1 Rab33b Rab33a Tbc1d2 Tbc1d7 Gabarapl2 Rab8b Rab8a Rab7a Rab7b Tbc1d14 Tbc1d13 Tbc1d16 Tbc1d15 Tbc1d17 Optn Rab11b Tbc1d10c Rab11a Rab35 Tsc2 Tsc1 Tbc1d10b Rab6b Tbc1d10a Rab6a Ulk1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10223785 SIRT1 negatively regulates rRNA expression Suv39h1 Rrp8 Hist1h2ai H2aj H2ab2 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Sirt1 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m H2bc1 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223611 Vasopressin-like receptors Avpr2 Oxtr Oxt Avpr1b Avp Avpr1a LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223439 Laminin interactions Nid2 Megf11 Lama4 Itgb1 Itga6 Itga7 MET ACTIVATES RAS SIGNALING%REACTOME DATABASE ID RELEASE 96%10224991 MET activates RAS signaling Hgf Grb2 Kras Shc1 Sos1 Hras Ranbp10 Met Nras Ranbp9 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-RNO-879415.1 Advanced glycosylation endproduct receptor signaling Capza1 Capza2 App S100b Ager Hmgb1-ps34 Hmgb1l2 Hmgb1l1 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10225389 Regulation of CDH11 gene transcription Zeb2 Sp1 INTERLEUKIN-2 SIGNALING%REACTOME%R-RNO-9020558.1 Interleukin-2 signaling Jak3 Shc1 Il2ra Il2rb Lck Il2 Syk Ptk2b Stat5a Stat5b RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 96%10222309 RNA Polymerase III Transcription Initiation From Type 1 Promoter Gtf3c5 Bdp1 Tbp Polr3gl Gtf3a Crcp Polr3a Polr3d Brf1 Polr1c Polr3e Polr3b Polr3c Polr2h Polr3f Polr3g Polr2e Gtf3c2 Polr2f Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-RNO-110320.1 Translesion Synthesis by POLH Rfc5 Ufd1 Uba52 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Vcp Rps27a Nploc4 Sprtn Rchy1 Rpa1 Rpa2 Ubb Rpa3 Ubc Polh INTERLEUKIN-38 SIGNALING%REACTOME%R-RNO-9007892.1 Interleukin-38 signaling Il1rl2 Il1f10 Il1rapl1 Mapk8 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190375.1 FGFR2c ligand binding and activation Fgf16 Fgf17 Fgf18 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf5 Fgf8 Fgf9 Fgfr2 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-RNO-176814.1 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 Cdk1 PI3K CASCADE%REACTOME DATABASE ID RELEASE 96%10222387 PI3K Cascade Irs2 Pik3r4 Pdpk1 Frs2 Klb Irs1 Trib3 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgfr3 Fgf7 Fgfr4 Fgf9 Fgfr1 Fgfr2 Fgf16 Them4 Pde3b Tlr9 Fgf17 Pik3ca Fgf18 Fgf19 Gab2 Fgf10 Akt2 Pik3r1 Pik3cb Grb2 Pik3r2 Ptpn11 Fgf20 Kl Fgf23 Flt3 Fgf22 Pik3c3 Gab1 RHOBTB GTPASE CYCLE%REACTOME%R-RNO-9706574.1 RHOBTB GTPase Cycle Cpsf7 Txnl1 Phip Stk38 Rbbp6 Cct7 Cops4 Cops2 Actb Tmod3 Rhobtb2 Rhobtb1 Actn1 Rock2 Ddx39b Rock1 Myo6 Pde5a Hsp90ab1 Rnf20 Cct6a Spen Hsp90aa1 Gps1 Rbmx Hnrnpc Cdc37 Tra2b Twf1 Cct2 Cul3 Vim Msi2 Srrm1 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 96%10223773 Arachidonate production from DAG Mgll Abhd12 Dagla Daglb Abhd6 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 96%10224759 Phospholipase C-mediated cascade; FGFR2 Fgf16 Fgf17 Fgf18 Fgf10 Plcg1 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgf7 Fgf9 Fgfr2 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%10224449 Establishment of Sister Chromatid Cohesion Smc3 Stag2 Esco1 Stag1 Wapl Esco2 Pds5b Pds5a Cdca5 Smc1a REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-RNO-170822.1 Regulation of Glucokinase by Glucokinase Regulatory Protein Nup133 Nup210 Nup155 Nup153 Gck Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Gckr Aaas Ranbp2 Nup214 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-RNO-68881.1 Mitotic Metaphase Anaphase Transition Plk1 Fbxo5 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224821 LGI-ADAM interactions Adam22 Cacng8 Cacng3 Stx1a Cacng4 Cacng2 Stx1b Lgi2 Lgi3 Lgi4 Lgi1 Dlg4 Adam23 Adam11 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-RNO-983695.1 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Itpr3 Itpr2 Itpr1 Ptpn6 Pik3r1 Cd19 Grb2 Vav1 Sos1 Pik3cd Sh3kbp1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 Dapp1 ENSRNOG00000070415 Cd22 ENSRNOG00000070810 Blnk ENSRNOG00000066926 Cd79a ENSRNOG00000066406 Cd79b ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Pik3ap1 Syk Iglc1 Nck1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 Trpc1 ENSRNOG00000063707 Plcg2 Stim1 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Btk ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 96%10225283 Assembly and cell surface presentation of NMDA receptors Grin2a Grin1 Grin2d Grin2c Grin2b Grin3a REGULATION OF COMPLEMENT CASCADE%REACTOME%R-RNO-977606.1 Regulation of Complement cascade Cpb2 Cr2 Serping1 Cr1l Clu Cd81 C4b C1qb C1qa Cfh Cfi C2 C5ar2 Elane C4 C5ar1 C9 Cd46 Cfhr1 C1s C1r Cpn1 Cpn2 Cd19 C1qc ENSRNOG00000069193 AABR07065813.1 F2 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 C3ar1 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 C3 C5 Cd55 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-RNO-5610780.1 Degradation of GLI1 by the proteasome Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Gli1 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Itch Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Sufu Numb Skp1 Psmb5 Psmb4 Psmb7 RAS PROCESSING%REACTOME%R-RNO-9648002.1 RAS processing Golga7 Arl2 Abhd17b Abhd17a Prkcq Lypla1 Nras Icmt Kras Pde6d Fnta Abhd17c Hras Bcl2l1 Calm3 Fntb Rce1 ENSRNOG00000067432 Prkg2 Zdhhc9 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224159 SHC1 events in ERBB2 signaling Prkce Egfr Erbb2 Shc1 Erbb3 Ereg Nrg2 Ptpn12 Nrg3 Hbegf Prkcd Btc Prkca Egf INTERFERON GAMMA SIGNALING%REACTOME%R-RNO-877300.1 Interferon gamma signaling Ifngr2 Ybx1 Ifngr1 Raf1 Jak2 Stat1 Ptpn6 Mapk3 Prkcd Socs3 Mapk1 Camk2g Camk2d Camk2b Pias1 Ptpn2 Socs1 Sumo1 Camk2a Ifng CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 96%10224845 CD22 mediated BCR regulation Ptpn6 Lyn ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 Cd22 ENSRNOG00000070810 ENSRNOG00000066926 Cd79a ENSRNOG00000066406 Cd79b ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-RNO-5693607.1 Processing of DNA double-strand break ends Sumo3 Rnf8 Rhno1 Nsd2 Rad50 Babam1 Babam2 Topbp1 Rbbp8 Brca1 Hist1h2bq Uimc1 Rad1 Ccna1 Ccna2 Hist3h2ba Blm Wrn H2bc4 Hist1h4m H2bc1 Dna2 Ppp4r2 Pias4 Ube2n Mre11 Ube2i Kat5 Timeless Nbn Hus1 Atrip Sirt6 Chek1 Ube2v2 Rad9a Rpa1 Rad9b Rpa2 Bard1 Top3a Rpa3 Ppp4c Clspn Rad17 Rfc5 Rfc3 Rfc4 Rfc2 Cdk2 Atm Atr Tp53bp1 Exo1 Rmi2 Rmi1 Brip1 Brcc3 ENSRNOG00000066901 Herc2 Rnf168 ABRAXAS1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-RNO-5358565.1 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Pold2 Pold1 Mlh1 Msh6 Pcna Msh2 Pms2 Pold4 Pold3 Exo1 Rpa1 Rpa2 Rpa3 Lig1 RAC3 GTPASE CYCLE%REACTOME%R-RNO-9013423.1 RAC3 GTPase cycle Lman1 Ophn1 Stbd1 Rac3 Noxo1 Arhgap35 Mpp7 Cyba Srgap2 Vamp3 Cybb Racgap1 Ocrl Cdc42ep1 Garre1 Itgb1 Syde1 Nckap1l Arhgap42 Snap23 Jag1 Tiam1 Arhgap32 Pak1 Cav1 Nox3 Swap70 Git1 Nox1 Pak2 Baiap2 Amigo2 Noxa1 Pik3r1 Rapgef1 Emd Baiap2l1 Pik3r2 Taok3 Vav2 Esyt1 Tfrc Abi2 Abi1 Pak4 Vrk2 Git2 Epha2 Abl2 Slc1a5 Ncf1 Abr Dock10 Ncf2 Ykt6 Ncf4 Pgrmc2 Brk1 Prex1 Bcr Trio Arhgap6 Arhgap15 Arhgap5 Arhgap17 Arhgap1 Dsg2 Arap3 Arap2 Rab7a Mcam Slitrk5 Slitrk3 Wasf2 Wasf1 Arhgdib Diaph3 Fermt2 Depdc1b Lamtor1 Lbr Cdc42 Arhgap21 Nckap1 Mcf2 Arhgap26 Cyfip1 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME%R-RNO-446652.1 Interleukin-1 family signaling Il33 Il1rap Map3k3 Il1rn Irak4 Irak3 Tollip Il1a Il1b Il1r2 Il1r1 Il1rl2 Nkiras1 Il1f10 App Ikbkb Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Gsdmd Nfkb1 Traf2 Fbxw11 Il36a Il36rn Il36g Alpk1 Rela Il18rap Il18r1 Il18bp Peli2 Il18 Peli3 Tifa Tnip2 S100b Map2k6 Hmgb1-ps34 N4bp1 Casp8 Nfkbib Tbk1 Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Usp14 Tab3 Tab2 Usp18 Tab1 Ctsg Nlrc5 Chuk Stat3 Il1rapl1 Psma4 Psma3 Sqstm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Il1rl1 Myd88 Ubb Ubc Psmb6l1 Psmd7 Casp1 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 96%10222627 PAOs oxidise polyamines to amines Smox ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME DATABASE ID RELEASE 96%10224235 Acyl chain remodeling of DAG and TAG Dgat2l6 Mgll Dgat2 Dgat1 Pnpla3 Awat2 Pnpla2 U12 DEPENDENT SPLICING%REACTOME%R-RNO-72165.1 U12 Dependent Splicing Polr2j Sf3b1 Ncbp2 Ncbp1 Sf3b3 Sf3b4 Sf3b5 Snrpepl2 Gtf2f2 Prpf6 Gtf2f1 Zmat5 Pdcd7 Prpf8 Snrnp200 Zcrb1 Snrpf Snrnp40 Eftud2 Snrnp48 Snrpg Ybx1 Snrpb Ddx42 Rnpc3 Zrsr2 Snrpd1 Snrnp25 Polr2c Polr2a Polr2b Srsf1 Polr2g Ddx23 Polr2h Polr2e Srsf7 Polr2f Snrpd3 Polr2i Srsf2 Snrnp35 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 96%10224037 Spry regulation of FGF signaling Ppp2cb Ppp2ca Uba52 Braf Ppp2r1a Mapk3 Src Spry2 Mknk1 Cbl Mapk1 Rps27a Grb2 Ptpn11 Ubb Ubc REUPTAKE OF GABA%REACTOME%R-RNO-888593.1 Reuptake of GABA Slc6a1 Slc6a11 Slc6a13 Slc6a12 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 96%10223287 Negative regulation of the PI3K AKT network Erbb2 Ppp2cb Ins2 Erbb3 Ppp2ca Ereg Frs2 Btc Il33 Pdgfa Ppp2r5d Pdgfb Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Il1rap Irak4 Fgf17 Fgf18 Fgf19 Ppp2r1b Ppp2r1a Fgf10 Mapk3 Hbegf Src Ntrk3 Ntf3 Grb2 Fyn Tgfa Fgf20 Fgf23 Areg Fgf22 Kit Traf6 Ppp2r5b Ppp2r5a Pten Pip5k1b Kitlg Ppp2r5e Klb Irs1 Fgf2 Fgf1 Fgf4 Lck Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Hgf Egfr Rhog Irak1 Rac2 Pdgfrb Pdgfra Kl Flt3 Esr1 Nrg2 Nrg3 Met Egf Trib3 Them4 Pik3ca Insr Rac1 Gab2 Pip5k1c Akt3 Akt2 Akt1 Pik3r1 Pik3cb Cd19 Pik3r2 Pik3r3 Vav1 Pik3cd Ptpn11 Gab1 Pik3r5 Pik3cg Irs2 Ier3 Phlpp1 Pip4k2b Pip4k2c Pip4k2a Pik3ap1 Cd28 Icos Ntf4 Pip5k1a Strn Cd86 Cd80 Esr2 Bdnf Il1rl1 Trat1 Myd88 Ntrk2 Mapk1 Pik3r6 Ins1 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450408.1 AUF1 (hnRNP D0) binds and destabilizes mRNA Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Hspa8 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Hspa1b Psmc3 Hspa1a Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Hnrnpd Psmd14 Psmd13 Hspb1 Pabpc1 Psmb5 Psmb4 Psmb7 SIGNALING BY VEGF%REACTOME DATABASE ID RELEASE 96%10223073 Signaling by VEGF Pdpk1 Prkaca Ctnnb1 Prkacb Plcg1 Prkcd Prkca Cyba Cybb Mapk12 Rasa1 Trib3 Calm3 Flt1 Flt4 Itgb3 Vegfa Kdr Elmo2 Ptk2b Nckap1l Vegfd Vegfc Rock2 Pgf Rock1 Vegfb Them4 Pxn Pik3ca Nck2 Rac1 Pak1 Cav1 Pak3 Pak2 Akt3 Baiap2 Ptk2 Akt2 Akt1 Pik3r1 Src Rhoa Pik3cb Hsp90aa1 Nras Vav3 Pik3r2 Fyn Vav1 Kras Vav2 Mapk13 Hras Abi2 Abi1 Sphk1 Nck1 Ncf1 Ncf2 Ncf4 Rictor Ctnna1 Prkcz Brk1 Prr5 Nrp1 Jup Nrp2 Shb Ctnnd1 Sh2d2a Elmo1 Mapkap1 Axl Bcar1 Wasf3 Wasf2 Shc2 Mapkapk3 Wasf1 Mapk14 Prkcb Mapkapk2 Mtor Nos3 Hspb1 Cdc42 Mapk11 Nckap1 Itgav Mlst8 Crk Cyfip2 Cyfip1 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-RNO-1650814.1 Collagen biosynthesis and modifying enzymes Plod1 Plod2 Adamts3 Bmp1 Adamts2 Col15a1 Col13a1 Col19a1 Col25a1 Col4a1 Col4a2 Adamts14 P4hb Col7a1 Tll2 Tll1 Gpr162 Col14a1 Col10a1 Ppib Col1a2 Col3a1 Col28a1 Col22a1 Col5a2 Col5a3 Col24a1 Col4a4 Col5a1 Col9a2 Col9a3 Pcolce Col20a1 Col11a1 Col11a2 Colgalt1 P3h2 P3h1 Crtap Col18a1 Pcolce2 Colgalt2 Col2a1 Col27a1 Col6a2 Serpinh1 Col23a1 Col6a5 Col6a6 Col26a1 Col4a5 Col6a3 Col8a1 Col4a6 Col8a2 Plod3 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 96%10224849 Gap-filling DNA repair synthesis and ligation in GG-NER Pole Rfc5 Pold2 Uba52 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pold4 Pold3 Rps27a Pole3 Pole2 Pole4 Rpa1 Rpa2 Polk Ubb Rpa3 Ubc RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-RNO-73857.1 RNA Polymerase II Transcription Runx3 Ywhag Suz12 Cox5a Cox5b Zfp12 Eed Zfp13 Zfp950l16 Zfp282 Ttc5 Nr2c1 Ice2 Kctd1 Rbbp4 Pou4f1 Rbbp7 Znf431l2 Pou4f2 Zfp668 Prkab2 Znf689 Prkab1 Zfp664 ENSRNOG00000065205 Zfp658 Zfp655 Ssu72 Znf624l Ube2d3 Zfp641 Zfp647 Znf667 Znf426 Aff4 Cox4i1 Cox4i2 Nr2f6 Nr0b2 Nr0b1 Nr2f1 Nr2e3 Gadd45a Zfp212 Zfp213 Zfp455 LOC134478826 Mapk3 Rex2l4 Zfp445 Zfp688 Zfp950l5 Usp9x Snapc3 Snapc4 Snapc1 Snapc2 Map2k6 Lamtor3 Kat2a Lamtor2 Maml3 Rbpj Hdac2 Hdac5 Hdac4 Maml1 Mapk14 Hdac11 Maml2 Hdac10 Notch3 Hdac9 Hdac8 Cpap Mapk11 Ywhab Gpx2 Tgfb1 Wwox Furin Nr1h4 Ell Ccnk Tcea1 Ccnt2 Cdk13 Cdk12 Ssrp1 Eloa2l Eloa Txnrd1 Akt3 Akt2 Akt1 Gsr Ccne1 Ccne2 Steap3 Tsc2 Tsc1 Tfdp2 Tfdp1 Rbl1 Rpa1 Rpa2 Rpa3 Chm E2f4 E2f5 Cdkn1b Ywhae Rptor RragB Ppm1a Mtor Rheb Slc38a9 Lamtor5 Lamtor4 Rraga Lamtor1 Lbr Rragc Rragd Stk11 Mlst8 Brpf3 Rnf111 Src Blm Wrn Dna2 Mre11 Ube2i Eloc Kat5 Elob Atad2 Nbn Lhb Hus1 Cga Atrip Chek1 Chek2 Rad9a Rad9b Bard1 Top3a Rad17 Rfc5 Rfc3 Rfc4 Pcna Kmt5a Rfc2 Atm Atr Exo1 Sirt1 Rmi2 Rmi1 Brip1 Sp1 Sumo1 Rhno1 Rad50 Ehmt1 Ing5 Brd1 Topbp1 Rbbp8 Brca1 Rad1 Smyd2 Brpf1 Kat6a Meaf6 Med1 Sfn Plk3 Ccnc Prdm9 Pparg Rnf34 Phf20 Gls Snrpf Snrpg Snrpb Nr2c2 Prmt5 Gpi Cdc25c Ctr9 Paf1 Smurf1 Mdm4 Ywhaq Ywhah Snrpd3 Ywhaz Zfp385a Snrpepl2 Pdpk1 Ctnnb1 Men1 Sirt3 Gls2 Arnt2 Tcf7 Arnt Tcf7l1 Tcf7l2 Cdc73 Pcf11 Fip1l1 Cstf1 Zfp473 Papola Nudt21 Polr2c Cstf2 Polr2a Cstf3 Polr2b Cstf2t Polr2g Lsm10 Polr2h Lsm11 Nelfa Sympk Polr2e Pabpn1 Polr2f Clp1 Nelfb Smurf2 Cpsf4 Polr2i Nelfe Cpsf6 Cpsf7 Polr2j Ctdp1 Cpsf1 Lef1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Leo1 Gtf2h2 Gtf2h1 Supt4h1 Gtf2f2 Gtf2f1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Banp Slbp Txn Cycsl2 Cycs Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 Psma1 Chd3 Rps27a Chd4 Psmd12 Psmd11 Psmd14 Psmd13 Mta2 Nr1h3 Mbd3 Nr1h2 Cbx3 Psmb5 Gatad2a Psmb4 Rxrb Gatad2b Psmb7 Rxra Psmb6 Ccnb1 Psmb1 Psmb3 Pgr Psmb2 Rxrg Uba52 Tbl1x Ube2d1 Psma7 Aurka Cited1 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Esr2 Psmc3 Cdk9 Hdac3 Pou2f1 Ubb Tbl1xr1 Rara Ubc Foxo3 Psmb6l1 Npm1 Psmd7 Ppard Psmd6 Psmd8 Myc Psmd2 Mt-co3 Mt-co2 Ncor2 Psmd1 Adrm1 Cdk2 Cdk1 Rarg Mapk1 Mt-co1 Nr5a2 Notch4 Ar Ppp2cb Ppp2ca Foxo4 Zfp839 Ddit4 Higd1c Cited4 Cited2 Zfp819 Plk2 Igfbp3 Phax Tmem219 Ell2 Ell3 Atxn3 Btg2 Zik1 Cdk5r1 Usp2 Zfp867 Zfp866 Zfp612 Zim1 Zfp617 Usp7 Zfp605 Zfp46 Zfp804b Rprd1a Rprd1b Supt6h Sesn2 Zfp418l1 Ppp2r1b Sesn1 Ppp2r1a Smad2 Cnot11 Cdk5 Smad3 Sesn3 Smad4 Kdm5b Tfap2e Smad7 Cnot10 Npas4 Tp53rkb Tp53rka Zfp52 Znf354c Znf354b Znf354a Tnks1bp1 Zfp90 Zfp78 Zfp74 Maged1 LOC102546572 Zfp81 Skil Cox7a1 Cox7a2 Mllt3 Mllt1 Atp1b4 Zfp873l3 Ints4 Ints5 Ints6 Zfp398 Ints7 Ints8 Ints9 Cox7a2l Ints1 Ints2 Ints3 Zfp386 Cnot6l Zfp764l1 Rffl Zfp133 Znf382 Cradd Pidd1 Znf394 Tpx2 Tp63 Nabp1 Nabp2 Esrra Tp53 Esrrb Zfp273l-ps1 Skic8 Esrrg Zfp180 Zfp189 Parp1 Zfp184 Ccng1 Zfp169 H2ab2 Arid1a LOC102547287 Arid1b Zfp94l1 LOC108348267 Lmo2 Zfp455l1 Lmo3 Ccnh Zfp790 Zfp317 H2ac4 Serpinb13 Zfp799 Zfpm1 Zfp300 Nr1i2 Actl6a Zfp786 Actl6b Zfp788 Smarce1 Rsl1 Gata3 Zfp770 Gata1 Znf773 Gata2 Zfp775 Setd1b Yeats4 Setd1a Ring1 Wwtr1 Abl1 Zfp764 ENSRNOG00000066901 Zfp763 Tp73 Jmy Ccnd2 Zfp111 Phc2 Zfp113 Nr3c2 Cbx6 Zfp597 Nr3c1 Ccnd3 Znf750 Phc1 Tgif1 Cbx4 Tgif2 Cbfb Zfp599 Ccnd1 Nr1d2 Cbx2 Nr1d1 Vdr Esr1 Zfp583 Phc3 Zfp101 Kmt2d Dyrk2 Crebbp Ndufa4 L3mbtl2 Cdk7 Iws1 Daxx Cdk6 Dek Kmt2a Trim33 Kmt2b Znf740 Kmt2c Zfp566 H2ac18 Ing2 Zfp324 Ppara Tcf3 Bax Sin3a LOC120095871 Nr1i3 Sin3b Zfp954 Csnk2a2 Zfp951 Ctsk Trim28 Zfp790l2 Ctsl Zfp710 Csnk2a1 Pcgf2 Rnmt Zfp952 Srrt Bmi1 Thrb Znf18 Mnat1 Thra Zfp719 Pbrm1 Prdx2 Brd7 Prmt6 Prdx5 Hist1h2bq Zfp704 Prmt1 Zfp945 Smarcb1 Zfp703 Hdac1 Nr5a1 Zfp706 Wdr5 Zfp948 Ash2l ENSRNOG00000070049 Yaf2 Prdx1 L3mbtl1 Csnk2b Pax5 Tp53bp2 H2aj Taf9 Taf9b Nrbf2 Tfap2c Elf1 Nrbf2l1 Tfap2a Taf15 Elf2 Tead4 Tal1 Tfap2b Taf11 Zfp758 Smarca2 Taf10 Zscan25 Smarca4 Taf13 Zscan22 Foxp3 Taf12 Pou2f2 H3-3b Tbp Zfp746 Yap1 Taf4b Krba1 Hist3h2ba Taf7l-ps1 Ep300 Pcgf6 Gtf2a1 Noc2l Gtf2a2 Rnf2 Tead3 Gtf2b ENSRNOG00000068602 Ski Itch Taf8 Tead2 Smarcd1 Taf7 Tcf12 Tigar Taf6 Zfp964 Smarcd3 Taf5 Pcgf5 Hipk1 Gtf2e1 Cox6a1 Smarcd2 Taf4 Cox6a2 Ptpn11 Taf2 Zfp286a H2bc18 Taf1 Rabggta Runx1 Gtf2e2 Kat2b Rabggtb Ppp1r13l H2az2 Ppp1r13b Rbbp5 Zfp119bl H2bc4 Max Hist1h4m H2bc1 Cox6c2 Pml Cnot3 Smarcc1 Cnot2 Hist1h2ai Cnot1 Nek4 Pip4k2b Cnot7 Pip4k2c Cnot6 Pip4k2a Cnot4 Rorc Cnot9 Rorb Foxo6 Cnot8 Ints13 Ints14 Sgk1 Cox6b1 Nr4a1 Ints11 Cox6b2 Ints12 Rictor Ints10 Zc3h8 Rngtt Foxg1 Prr5 Rprd2 G6pdx Casp2 Mga Zfp37-ps1 Mapkap1 Tbx5 E2f6 E2f7 E2f8 Zfp275 Epc1 Zfp1 Zfp266 Zfp263 Nr6a1 Zfp496 Zfp808l3 Prkaa1 Pip4p1 Eaf1 Prkaa2 Eaf2 Zfp483 Cox8a Rpap2 Cox8c Zfp248 Nuak1 Hnf4a Cox7b Foxo1 Hnf4g Cox7c Zkscan8 Prkag3 Zkscan7 Prkag1 Zkscan1 Prkag2 Zkscan4 Zkscan5 Zkscan3 Bnip3l Nr4a3 Nr4a2 Mapkapk5 Ezh2 Zfp955a Zfp955b Bmal1 Nrif1 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%10225383 Regulation of CDH11 Expression and Function Zeb2 Jup Ctnnd1 Ctnnb1 Sp1 Cdh11 Amot Adam19 Angptl4 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 96%10223827 Localization of the PINCH-ILK-PARVIN complex to focal adhesions Pxn Itgb1 Parva Ilk RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-RNO-110373.1 Resolution of AP sites via the multiple-nucleotide patch replacement pathway Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Lig1 Parg Polb Fen1 Pole Parp2 Parp1 Rfc5 Pold2 Apex1 Adprs Pold1 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pold4 Pold3 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-RNO-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV Bckdhb Dld Bckdha Dbt TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222097 Tyrosine catabolism Hpd Fah Hgd Tat Gstz1 DIGESTION OF DIETARY LIPID%REACTOME DATABASE ID RELEASE 96%10223161 Digestion of dietary lipid Cel Pnliprp2 Pnliprp1 Lipf Clps Pnlip UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-RNO-9758881.1 Uptake of dietary cobalamins into enterocytes Cblif Cubn Amn SEMAPHORIN INTERACTIONS%REACTOME%R-RNO-373755.1 Semaphorin interactions Rhoc Cd72 Erbb2 Plxnb3 Sema6d Gsk3b Crmp1 Plxna4 Plxna3 Plxna2 Rras Met Tyrobp Sema4a Dpysl3 Dpysl4 Dpysl5 Arhgap35 Plxnc1 Tln1 Sema3a Sema7a Fes Trem2 Sema3e Plxna1 Cdk5r1 Rock2 Rock1 Plxnd1 Rac1 Pak1 Rnd1 Pak3 Farp2 Pak2 Cdk5 Pip5k1c Sema5a Arhgef11 Ptprc Rhoa Hsp90aa1 Arhgef12 Fyn Limk1 Sema4d Plxnb1 Nrp1 Hsp90ab1 Rhob Dpysl2 SUMOYLATION%REACTOME DATABASE ID RELEASE 96%10224493 SUMOylation Nup133 Nup210 Suz12 Nup155 Nup153 Mrtfa Senp5 Senp5l1 Sumo2 Senp2 Ctbp1 Blm Nop58 Ikbkg Pias4 Ube2i Nfkb2 Rela Hdac2 Parp1 Hdac4 Pcna Xrcc4 Nfkbia Ikbke Tp53bp1 Nr1i2 Smc6 Smc5 Smc3 Pias3 Senp1 Ddx17 Sp140 Pias1 Pias2 Ring1 Nsmce4a Casp8ap2 Hic1 Eid3 Herc2 Uhrf2 Phc2 Rnf168 Nr3c2 Sumo1 Cetn2 Nr3c1 Nsmce1 Phc1 Nsmce2 Cbx4 Sumo3 Xpc Zfp131 Sp3 Cbx2 Vdr Esr1 Stag2 Phc3 Stag1 Dnmt1 L3mbtl2 Nr1h4 Daxx Rad52 Safb Mageb10 Sp100 Ing2 Ppara Sin3a Top2b Top2a Top1 Trim28 Trim27 Uba2 Pcgf2 Rwdd2b Bmi1 Thrb Sae1 Thra Brca1 Mbd1 Satb2 Satb1 Park7 Smc1a Hdac1 Nr5a1 Tfap2c Ep300 Nrip1 Rnf2 Mitf Tdg Mta1 Nr1h3 Nr1h2 Hist1h4m Rxra Pml Vhl Pgr Cdca8 Incenp Aurkb Rpa1 Nup93 Nup50 Nup35 Rara Nup54 Nup98 Npm1 Nup58 Rangap1 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Hnrnpc Nup85 Nup42 Hnrnpk Nr5a2 Nup62 Nup43 Nup88 Birc5 Ar Aaas Ranbp2 Nup214 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-RNO-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins Alox5 Alox15 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-RNO-2173782.1 Binding and Uptake of Ligands by Scavenger Receptors Hsp90b1 Jchain Hpx Alb Prdx1 Hp Cd163 Apoa1 Apoe LOC120093819 Ambp Apob Lrp1 Apol7al1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 Apol2 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 Msr1 ENSRNOG00000066926 Calr Apol7bl1 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 Scarb1 ENSRNOG00000070192 Cd36 S100a9 Iglc1 ENSRNOG00000070159 Hba1 ENSRNOG00000071049 Hbb AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Stab1 ENSRNOG00000067679 ENSRNOG00000070832 Hmgb1-ps34 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 Sparc ENSRNOG00000066904 ENSRNOG00000063713 Apol9a ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 Hmgb1l2 ENSRNOG00000069940 Hmgb1l1 ENSRNOG00000067643 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-RNO-9634815.1 Transcriptional Regulation by NPAS4 Maged1 Npas4 Arnt2 Bmal1 Arnt NICOTINATE METABOLISM%REACTOME%R-RNO-196807.1 Nicotinate metabolism Naprt Slc22a13 Naxe Naxd Nmnat3 Nmnat2 Qprt Nadk2 Slc25a51 Nudt12 Nmrk1 Slc5a8 Bst1 Cd38 Nadsyn1 Nadk Nmnat1 Rnls Nt5e Nampt ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 96%10221983 Activation of ATR in response to replication stress Cdc6 Mcm7 Mcm8 Dbf4 Hus1 Atrip Mcm3 Mcm4 Mcm5 Mcm10 Mcm2 Chek1 Rad9a Rpa1 Rad9b Rpa2 Rpa3 Rad1 Clspn Rad17 Rfc5 Rfc3 Rfc4 Cdc25c Rfc2 Cdk2 Atr Cdc25a Orc4 Orc6 Orc1 Orc3 Orc2 Cdc7 FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%10222083 Fatty acid metabolism Phyh Amacr Eci2 Akr1c18 Abcc1 Akr1c12l1 Akr1c19 Hacl1 Hsd17b3 Akr1c21 Mlycd Scp2 Prkab2 Crat Acox1 Hsd17b12 Acox2 Ggt1 Ehhadh Acox3 Ggt5 Akr1c3l1 Akr1c12 Hpgds Akr1c1 Akr1c13 Acaa1b Hsd17b4 Akr1c9 Hao2 Pecr Acbd5 Slc27a2 Aldh3a2 Decr2 Crot Nudt19 Acot1 Acot2 Acot5 Acot3 Acot4 Acot8 Abcd1 Echs1 Cyp1b1 Hadh Eci1 Cbr1 Acadm Decr1 Tbxas1 Ptges Ptgds Ptgis Ptges2 Ptgs1 Pon3 Pon1 Mecr Mapkapk2 Morc2 Gpx2 Aloxe3 Gpx1 Alox12b Hadha Hadhb Acadl Cyp8b1 Cyp2u1 Hacd1 Hacd2 Ltc4s Hacd3 Hacd4 Hsd17b8 Dpep1 Dpep2 Mcat Them4 Acad11 Elovl2 Acly Elovl3 Acaa2 Elovl5 Elovl1 Elovl6 Elovl7 Tecrl Faah Acbd6 Acbd4 Ppt2 Ppt1 Acsf3 Acsf2 Dbi Acot11 Scd1 Acot12 Acot13 Them5 Acot9 Acot7 Acsl1 Acsl5 Acsl6 Acsl3 Acsl4 Rxra Fads2 Pon2 Acoxl Fads1 Acadvl Alox15b Alox12 Cbr4 Tecr Alox5ap Acsbg1 Gpx4 Pctp Acads Alox5 Acsbg2 Lta4h Ndufab1 Acaca Alox15 Cyp2c66 Fasn Cyp2c11 Cyp1a1 Ephx2 Cyp1a2 Slc22a5 Awat1 Ptgs2 Mmut Pcca Ppard Pccb Ptges3 Prkaa2 Cyp2j16 Cyp4f39 Cyp2j3 Cyp4f1 Cyp4a14 Pla2g4a Cyp4f3 Cyp4a12 Cyp4f40 Cyp4b1 Prkag2 Cpt1a Mid1ip1 Cyp4f4 Thrsp Cpt2 Cyp4a10 Cyp4a2 Mmaa Cpt1b Slc25a20 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME%R-RNO-1655829.1 Regulation of cholesterol biosynthesis by SREBP (SREBF) Srebf1 Mbtps1 Scap Ran Kpnb1 Srebf2 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-RNO-352238.1 Breakdown of the nuclear lamina Lmna Lmnb1 Casp6 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-RNO-1280215.1 Cytokine Signaling in Immune system Ube2d3 Ube2d2 Ybx1 Creb1 Stx1a Mapk3 Rps6ka5 Nras Grb2 Tnfsf13 Fyn Kras Sos1 Tyk2 Hras Vamp2 Nkiras1 Eda Tnfrsf4 App Tnfrsf8 Mapk9 Atf2 Tnfrsf1b Ikbkb Edar Atf1 Tnfrsf11b Tnfrsf11a Mapk7 Nkiras2 Cd40lg Il6st Tnfsf4 Mapk8 Traf6 Cd40 Peli1 Tnfsf13b Ikbkg Ppp2r5a Tnfsf11 Map3k8 Tnfsf8 Map3k7 Tnfsf9 Ube2n Relb Tnfrsf9 Lrrc14 Nfkb2 Brwd1 Lta Tslp Nfkb1 Ltb Tnfrsf17 Traf2 Il7 Edaradd Il7r Tnf Fbxw11 Tnfsf15 Fos Tnfsf14 Tnfrsf1a Vrk3 Tnfsf12 Alpk1 Tnfrsf13c Rela Tnfsf18 Rps6ka3 Ltbr Tnfrsf25 Peli2 Eda2r Tnfrsf18 Rps6ka1 Peli3 Tnfrsf12a Map3k14 Tifa Irs1 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Kpnb1 Hmgb1-ps34 Dusp4 Kpna1 Ripk2 N4bp1 Dusp7 Tec Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Il6 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Il6r Map2k3 Usp14 Tab3 Tab2 Fnta Usp18 Tab1 Fntb Nlrc5 Chuk Mapk10 Ifi44 Mapk11 Ifi44l Flt3 Furin Grb10 Il1rapl1 Akt3 Akt2 Akt1 Vamp7 Hspa8 Prkra Sh2b1 Tarbp2 Stxbp2 Crk Stx4 Nedd4 Ube2l6 Lyn Yes1 Camk2g Camk2d Camk2b Camk2a Il34 Ptprz1 Il16 Txlna Csf1r Stx3 Eloc Elob Ube2m Il18 Cd4 Lck Ifng Ifngr2 Ifngr1 Raf1 Jak2 Ctsg Uba7 Sumo1 Birc2 Uba3 Cul5 Inpp5d Canx Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Csf2rb Csf1 Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Pik3r3 Inppl1 Pik3cd Sfn Irs2 Traf3 Ywhaz Csf3 Hspa1b Hspa1a Crkl Rapgef1 P4hb Il1rl2 Il1f10 Gsdmd Il36a Il36rn Il36g Il18rap Il18r1 Il18bp Sdc1 Ptpn1 Tbk1 Irf3 Mavs Rig1 Plcg1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Dnajc3 Eif2ak2 Sphk1 Psmb1 Fancl Psmb3 Fancm Psmb2 Pim1 Uba52 Fanca Fancb Fancc Mapt Ube2d1 Fance Fancf Cntf Btrc Fancg Cntfr Psma7 Nck1 Gbp5 Ifnlr1 Clcf1 Pde12 Ctf1 Ilf2 Psmc5 Il20rb Actb Psmc2 Il20ra Dus2 Psmc1 Ilf3 Il31ra Psmc4 Flnb Lif Snca Psmc3 Il10 Dhx9 Il11 Ppm1b Il22ra2 Osmr Mx2 Arih1 Il10rb Pggt1b Il10ra Il22 Trim25 Ptpn2 Il11ra1 Ubb Hspa1l Il20 Il24 Ubc Gbp2 Foxo3 Osm Gbp1 Il22ra1 Ube2e1 Gbp3 Psmb6l1 Faap100 Lifr Npm1 Ifnl1 Psmd7 Casp1 Ifnl3 Oasl Psmd6 Hspa2 Psmd8 Faap24 Fkbp5 Isg15 Psmd2 Faap20 Psmd1 Adrm1 Cul1 Cdk1 Becn1 Mapk1 Il12rb1 Il12rb2 Ebi3 Il12b Il27 Il23a Il12a Crlf1 Ppp2cb Ppp2ca Il23r Prkaca Prkcd Ghr Gh1 Prl Il33 Prlr Ppp2r5d Il1rap Map3k3 Il1rn Irak4 Irak3 Tollip Il1a Ppp2r1b Il1b Il1r2 Ppp2r1a Il1r1 Tp53 Snap25 Adar Pias1 Socs1 Il13ra2 Il4r Stat6 Il13 Hsp90b1 Socs5 Il4 Stat3 Stat1 Il15 Il15ra Il9 Il21 Actg1 Ptk2b Stat5a Stat5b Il9r Ifnar1 LOC120103158 Smarca4 LOC120103159 Ifnar2 Ifnb1 Rnasel Sqstm1 Ifna4 Ifna1 Ifna1l1 Ifna4l1 Irf9 Vav1 Ptpn11 H2bc18 Sos2 Syk Hck Il1rl1 Casp3 Myd88 Rbx1 Socs3 Cbl NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975957.1 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) LOC120093247 Ppp2ca Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Magohb Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Ppp2r1a Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Ncbp2 Ncbp1 Rpl23a Upf3b Upf3a Eif4a3 Smg1 Smg9 Smg8 Smg7 Smg6 Smg5 Upf1 Upf2 Rbm8a Casc3 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Pabpc1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Ppp2r2a Rps4x-ps13 Rpl38 Rps3a Etf1 Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Pnrc2 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rnps1 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Magoh Rpl12-ps1 Ubc Rps20 Rps21 Dcp1a Rpl22 Rps23 Rps24 Rpl23 Gspt2 Gspt1 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-RNO-174113.1 SCF-beta-TrCP mediated degradation of Emi1 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Fbxo5 Fzr1 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME%R-RNO-9036866.1 Expression and Processing of Neurotrophins Furin Pcsk5 Ngf Pcsk6 TRIGLYCERIDE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222301 Triglyceride metabolism Fabp1 Fabp2 Fabp3 Fabp4 Gk Fabp7 Mogat1 Fabp6 Pnpla5 Gpat2 Pnpla4 Mogat2 FABP12 Gpam Gpd2 Agmo Fabp9 Fabp5 Dgat2 Gykl1 Dgat1 Lpin3 Lpin2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-RNO-71336.1 Pentose phosphate pathway Rpe Taldo1 Prps1l3 Pgd Prps1 G6pdx Rpia Dera Prps2 Shpk Pgm2 Pgls Tkt Rbks DAP12 INTERACTIONS%REACTOME%R-RNO-2172127.1 DAP12 interactions Clec5a Siglec15 Siglec10 Klrd1 Klrc2 Klrk1 Klrc1 Tyrobp Syk Plcg1 Trem2 Trem1 Sirpa B2m Lck Plcg2 Grap2 Pik3ca Shc1 Rac1 Pik3r1 Pik3cb Nras Vav3 Grb2 Pik3r2 Fyn Btk Kras Vav2 Sos1 Hras Lat Lcp2 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-RNO-109606.1 Intrinsic Pathway for Apoptosis Ywhag Gsdme Casp7 Apip Gsdmd Diablol1 Apaf1 Ppp3cc Pmaip1 Bax Septin4 Bak1 Bad Casp3 Nmt1 Gzmb Bid Casp9 Xiap Ppp3r1 Ywhae Casp8 Bcl2l11 Cycsl2 Mapk3 Mapk1 Dynll1 Dynll2 Bcl2l1 Bmf Ywhaq Ywhah Cycs Sfn Ywhab Mapk8 Ywhaz RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-RNO-73933.1 Resolution of Abasic Sites (AP sites) Neil2 Lig3 Pnkp Neil1 Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Lig1 Parg Polb Fen1 Mpg Pole Ogg1 Parp2 Parp1 Rfc5 Mutyh Pold2 Apex1 Adprs Pold1 Rfc3 Rfc4 Pcna Rfc1 Xrcc1 Rfc2 Pold4 Pold3 Mbd4 Smug1 Nthl1 Tdg Ung ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223739 Adenosine P1 receptors Adora2b Adora2a Adora1 Adora3 JOSEPHIN DOMAIN DUBS%REACTOME%R-RNO-5689877.1 Josephin domain DUBs Rps27a Rad23a Rad23b Atxn3 Josd2 Uba52 Josd1 Ubb Ubc Prkn Vcp ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-RNO-1300645.1 Acrosome Reaction and Sperm:Oocyte Membrane Binding Izumo1 Cd9 Acr Izumo4 Izumo3 Izumo2 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-RNO-174184.1 Cdc20:Phospho-APC C mediated degradation of Cyclin A Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdc16 Cdk1 CHROMOSOME MAINTENANCE%REACTOME%R-RNO-73886.1 Chromosome Maintenance Itgb3bp Rsf1 Oip5 Mis18a Rbbp4 Rbbp7 Cenpw H2ac18 Hist1h2bq Terf2 Acd Terf1 Ruvbl1 H2aj Terf2ip Tinf2 Pot1 Ccna1 Ccna2 Hist3h2ba Ppp6r3 ENSRNOG00000068602 Knl1 Chtf8 Ppp6c Blm Wrn Chtf18 H2az2 Tert Ctc1 Stn1 H2bc4 Hist1h4m Ten1 Dscc1 H2bc1 Dna2 Shq1 Hist1h2ai Dkc1 Nhp2 Pif1 Gar1 Wrap53 Rtel1 Nop10 Cenpc Cenpa Cenpu Cenpt Cenpq Rpa1 Cenpp Ankrd28 Rpa2 Cenpo Cenpn Cenpm Rpa3 Cenpl Cenpk Cenpi Lig1 Cenph Npm1 Fen1 Rfc5 Pold2 Pold1 H2ab2 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Cdk2 H2ac4 Pola1 Pold4 Pold3 Prim2 Prim1 Mis18bp1 Hjurp Smarca5 ENSRNOG00000066901 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-RNO-349425.1 Autodegradation of the E3 ubiquitin ligase COP1 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Tp53 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Atm Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Cop1 Psmd13 Psmb5 Psmb4 Psmb7 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-RNO-8866654.1 E3 ubiquitin ligases ubiquitinate target proteins Pex5 Ube2n Leo1 Uba52 Ube2d1 Rnf181 Shprh Rad18 Rnf152 Rnf40 Rnf144a Hltf Wac Pex14 Ube2v2 Pex13 Ube2b Pex12 Ube2d3 Pex10 Ube2d2 Hist1h2bq Ube2a Ubb Prkdc Ubc Bcl10 Ube2e1 Skic8 Pcna Rnf20 Ctr9 Cdc73 Paf1 Rps27a Pex2 Rraga Ube2l3 ENSRNOG00000066901 H2bc4 H2bc1 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222875 TAK1-dependent IKK and NF-kappa-B activation Ikbkg Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Alpk1 Rela Tifa S100b Ubb Hmgb1-ps34 Ubc N4bp1 Casp8 Nfkbib Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Rps27a Usp14 Tab3 Tab2 Usp18 Tab1 Nkiras1 Nlrc5 App Chuk Ikbkb Nkiras2 Traf6 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-RNO-75955.1 RNA Polymerase II Transcription Elongation Iws1 Cdk7 Ell Ccnk Tcea1 Ccnt2 Ssrp1 Eloa2l Mnat1 Eloa Aff4 Supt6h Cdc73 Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe Polr2j Ctdp1 Mllt3 Ncbp2 Mllt1 Ncbp1 Gtf2h2 Leo1 Gtf2h1 Supt4h1 Eloc Gtf2f2 Gtf2f1 Elob Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Cdk9 Skic8 Eaf1 Eaf2 Ccnh Ctr9 Paf1 LDL CLEARANCE%REACTOME%R-RNO-8964038.1 LDL clearance Ldlrap1 Lipa Cltc Soat2 Soat1 Npc2 Npc1 Ldlr Ap2s1 Apob Ap2a2 Ap2a1 Ap2b1 Pcsk9 Nceh1 Ap2m1 Clta CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-RNO-72737.1 Cap-dependent Translation Initiation LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Eif5 Rps14 Eif2b3 Rps15 Eif2b2 Rps16 Eif2s3 Rps17 Eif2b5 Rpl4 Rps15a Eif2b4 Rpl5 Rps18 Eif2s2 Rpl3 Rps19 Eif2b1 Rps27 Pabpc1 Eif2s1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Eif4h Rpl7 Rps26-ps13 Eif3m Eif3j Eif3i Rpl30 Eif3l LOC134486107 Eif3k Rpl31 Eif3f Rpl32 Eif3e Eif3h Rpl34 Eif3g Rpl36al1 Eif3b Eif3a Rpl39l1 Eif3d Rpl24 Eif3c Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Eif1ax Eif4a2 Eif4a1 Eif5b Fau Eif4ebp1 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 Eif4e TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-RNO-446107.1 Type I hemidesmosome assembly Plec Megf11 Dst Itga6 Cd151 Itgb4 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223943 Presynaptic function of Kainate receptors Grik3 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 96%10223767 Sodium Calcium exchangers Slc8a1 Slc24a4 Slc8a2 Slc24a3 Slc24a2 Slc8a3 Slc24a1 Calm3 Slc8b1 Sri Slc24a5 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224161 SHC1 events in ERBB4 signaling Grb2 Kras Shc1 Sos1 Ereg Hras Nrg2 Nrg3 Hbegf Btc Nras ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 96%10224453 Antagonism of Activin by Follistatin Fstl3 Fst Inhba Inhbb NUCLEOTIDE METABOLISM%REACTOME%R-RNO-15869.1 Nucleotide metabolism Itpa Dnph1 Nudt5 Atic Adsl Ppat Adss2 Pfas Paics Gart Adss1 Cda Umps Cad Samhd1 Pudp Dhodh Tk2 Uck1 Uck2 Dguok Gmpr2 Pnp Ampd3 Ampd2 Ampd1 Adk Rrm2b Gmpr Txnrd1 Hprt1 Dck Dtymk Nudt13 Aprt Dut Ada Rrm1 Tyms Rrm2 Ak1 Gsr Nme3 Ak2 Nme2 Ak5 Glrx Ak4 Ak7 Ak6 Ak9 Nme1 Cmpk1 Dctd Ak8 Nme6 Ctps2 Ctps1 Tymp Upb1 Upp1 Nt5c3a Upp2 Dpys Dpyd Nt5m Gmps Impdh2 Impdh1 Txn Entpd1 Entpd2 Entpd5 Entpd6 Entpd3 Entpd4 Entpd7 Entpd8 Xdh Nudt9 Nudt16 Gda Nudt18 Adprm Nt5c Nt5c1a Nt5c1b Nt5e Nudt1 Nt5c2 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-RNO-112409.1 RAF-independent MAPK1 3 activation Dusp7 Dusp6 Jak2 Dusp2 Pea15 Dusp5 Dusp1 Dusp9 Dusp8 Il6 Mapk3 Dusp16 Map2k2 Cdk1 Il6r Map2k1 Mapk1 Dusp10 ENSRNOG00000069024 Tyk2 Ptpn11 Il6st Dusp4 EGFR TRANSACTIVATION BY GASTRIN%REACTOME DATABASE ID RELEASE 96%10223707 EGFR Transactivation by Gastrin Mmp3 Grb2 Egfr Kras Sos1 Hras Hbegf Nras Prkca NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 96%10224497 Nuclear Pore Complex (NPC) Disassembly Nup133 Ccnb1 Nup210 Nup155 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Cdk1 Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Ccnb2-ps2 Nup43 Nup88 Aaas Ccnb2 Ranbp2 Nup214 RHOQ GTPASE CYCLE%REACTOME%R-RNO-9013406.1 RHOQ GTPase cycle Ophn1 Gopc Rhoq Arhgap35 Mpp7 Srgap2 Vamp3 Cdc42ep1 Plekhg3 Cdc42ep4 Syde1 Dlc1 Arhgef7 Scrib Snap23 Arhgap32 Pak1 Cav1 Git1 Pak2 Fnbp1 Steap3 Itsn1 Tfrc Trip10 Wwp2 Pak4 Git2 Obscn Slc1a5 Arhgef9 Prex1 Jup Arhgap5 Arhgap17 Arhgap1 Stom Rab7a Gja1 Arhgap33 Cdc42bpa Cdc42bpb Slc4a7 Iqgap3 Diaph3 Arl13b Cdc42ep2 Depdc1b Cdc42ep3 Lamtor1 Cpne8 Cdc42 Arhgap21 Arhgap26 Cftr REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10224937 Regulation of PTEN stability and activity Nedd4 Prex2 Csnk2a2 Trim27 Csnk2a1 Tnks2 Xiap Csnk2b Mkrn1 Psma4 Psma3 Akt3 Akt2 Akt1 Psma6 Psma5 Psma2 Stub1 Rnf146 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Tnks Psmd13 Wwp2 Otud3 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Pten Psma7 Usp13 Psmc5 Frk Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10222339 mitochondrial fatty acid beta-oxidation of saturated fatty acids Acadm Acadvl Hadha Hadhb Acadl Echs1 Hadh Acads Mecr COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%10224975 COPI-independent Golgi-to-ER retrograde traffic Agpat3 Dync1h1 Actr1a Pafah1b3 Pafah1b2 Dctn1 Actr10 Dctn2 Dync1i2 Dctn4 Dync1i1 Rab18 Galnt1 Galnt2 Pla2g6 Dync1li2 Dync1li1 Pla2g4a Dynll1 Dynll2 Pafah1b1 Rab3gap2 Rab3gap1 Rab6b Rab6a Bicd2 Bicd1 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-RNO-9855719.1 Regulation of FXIIa and plasma kallikrein activity Kng1 F12 Serping1 C1qbp A2m Hrg Krt1 Klkb1 Plaur AZATHIOPRINE ADME%REACTOME%R-RNO-9748787.1 Azathioprine ADME Gsta5 Gsta6 Gsta3 Gsta1 Gsta2 Rac1 Hprt1 Xdh Vav3 Nme2 Slc28a3 Vav1 Slc28a2 Vav2 Gmps Nme1 Abcc5 Impdh2 Tpmt Impdh1 Slc29a2 Abcc4 Slc29a1 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%10223915 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation Map3k7 Uba52 Irak2 Rps27a Tab3 Tab2 Tab1 Ly96 Ticam2 Ubb Ubc Ticam1 Cd14 Traf6 Tlr4 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-9022692.1 Regulation of MECP2 expression and activity Sin3a Hdac2 Lbr Hdac1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 96%10225091 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Ctsk Ctsl Serpinb13 RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-RNO-8941856.1 RUNX3 regulates NOTCH signaling Kat2a Runx3 Maml3 Rbpj Maml1 Crebbp Maml2 Kat2b Ep300 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-RNO-9018676.1 Biosynthesis of D-series resolvins Gpx4 Hpgd Alox5 Lta4h FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190322.1 FGFR4 ligand binding and activation Fgf16 Fgf17 Fgf18 Fgf19 Klb Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf8 Fgfr4 Fgf9 RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 96%10223745 RHO GTPases Activate ROCKs Rhoc Rhob Rock2 Rock1 Rhoa CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 96%10225109 Cristae formation Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Dmac2l Atp5mg Atp5f1b Atp5f1a Atp5po Atp5mk Mt-atp8 Mt-atp6 Atp5mc1 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 96%10225387 Regulation of Homotypic Cell-Cell Adhesion Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Src Fyn Ctbp1 Ctsb Cbll1 Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Mogs Angptl4 Vcl Hdac2 H2ab2 Twist1 Kmt5a H2ac4 Sec11c Amot Sec11a Prkcsh Sirt1 Zmym2 Sp1 ENSRNOG00000066901 Pomt1 Dnttip1 Pomt2 Furin Pcsk7 Pcsk6 H2ac18 Adam19 Ctbp2 Csnk2a2 Ctsl Zeb1 Csnk2a1 Zeb2 Hist1h2bq Hdac1 Cdh11 Ganab Csnk2b Mphosph8 H2aj Canx Arhgap32 Spcs3 Spcs1 Spcs2 Psma4 Smarca4 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Ezh2 Dad1 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-RNO-5656121.1 Translesion synthesis by POLI Rev1 Rev3l Poli Rfc5 Uba52 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Rps27a Rpa1 Rpa2 Ubb Rpa3 Ubc Mad2l2 AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 96%10225001 AURKA Activation by TPX2 Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Dync1h1 Csnk1d Ccp110 Dync1i2 Aurka Nde1 Nedd1 Haus7 Tpx2 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Clasp1 Tubg1 Ywhae Cep63 Cep152 Tuba4a Plk1 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Cdk1 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-RNO-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA Dld Dhtkd1 Dlst REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME%R-RNO-9617629.1 Regulation of FOXO transcriptional activity by acetylation Foxo1 Sirt3 Sirt1 Crebbp Kat2b Ep300 Foxo3 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%10224815 Negative regulation of MAPK pathway Ppp2r5b Ppp2r5a Ppp2cb Dusp2 Ppp2ca Ksr1 Dusp5 Uba52 Paqr3 Dusp1 Dusp9 Araf Dusp8 Dusp16 Ptpn7 Map2k2 Ptpn3 Ppp2r5e Map2k1 Dusp10 Mapk12 ENSRNOG00000069024 Pebp1 Ppp2r5d Ubb Ubc Dusp4 Brap Dusp7 Dusp6 Raf1 Braf Ppp2r1b Ppp2r1a Mark3 Mapk3 Nras Mapk1 Rps27a Kras Hras Ppp5c Ywhab UREA CYCLE%REACTOME%R-RNO-70635.1 Urea cycle Nags Slc25a2 Sirt5 Cps1 Arg2 Arg1 Slc25a15 Asl Otc RRNA PROCESSING%REACTOME%R-RNO-72312.1 rRNA processing LOC120093247 Heatr1 Nob1 Utp11 Ddx52 Rpl36a Utp18 Wdr43 Rrp7a Noc4l Dis3 Rplp2 Tex10 Riok1 Riok2 AABR07072440.1 Gnl3 Rpl35al8 Ddx49 Wdr36 Rpl22l1 Rplp0 Ddx47 Rplp1 Rpl13a Rpl35al2 Rpl18a Nip7 Rpl13 Rpl14 Rrp36 Rpl15 Mphosph6 Nol9 Rpl17 Rpp14 Rpl18 Rpl19 Nol6 Utp14a Mphosph10 Rpl10 Pes1 Rpl11 Bms1 C1d Rpl12 Rpl10a Exosc9 Exosc8 Exosc5 Krr1 Exosc4 Exosc7 Exosc6 Exosc1 Utp3 Exosc3 Utp4 Rps2 Exosc2 Utp6 Nop58 Nop56 Bop1 LOC134480579 Ebna1bp2 Csnk1d Wdr18 Tsr1 Ddx21 Rpl23a Wdr12 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Las1l Rps27 Ltv1 Rpsa Rpl35 Rps10 Fcf1 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rrp9 Rps8 Rpl6 Rps5 Pwp2 Rpl7 Rps26-ps13 Rpp38 Bysl Fbl Rpl30 LOC134486107 Rpl31 Rpl32 Rpp30 Rpl34 Rpl36al1 Ftsj3 Rpl39l1 Rpl24 Rpl26 Rps3 Imp4 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rpp25 Rps29 Rpl12-ps1 Ubc Rps20 Ncl Rps21 Rpl22 Rps23 Xrn2 Rps24 Rpl23 Snu13 Wdr75 Senp3 Fau Isg20l2 Exosc10 Emg1 Eri1 LOC120097744 Dhx37 Rpl36l5 Rpl36l3 Rpl3l Pdcd11 Pno1 Rpl27a Rpl31l15 Utp20 Nop14 Pelp1 Rcl1 Utp25 Tbl3 Nol11 Rps6 Rpp40 LOC100910714 LOC102551819 Wdr3 Bud23 Dcaf13 Csnk1e Utp15 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%10223035 PI-3K cascade:FGFR3 Fgf16 Fgf17 Pik3ca Fgf18 Frs2 Pik3r1 Grb2 Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Fgf9 Gab1 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 96%10223967 Ovarian tumor domain proteases Ikbkg Uba52 Esr1 Pten Apc Ube2d1 Tnip2 Nod2 Nod1 Ubb Ubc Tp53 Ripk2 Yod1 Otub1 Rhoa Cdk1 Vcp Ripk1 Rps27a Otud7a Otub2 Otud7b Vcpip1 Traf3 Tnip3 Rnf128 Tnip1 Otud3 Zranb1 Traf6 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-RNO-1663150.1 The activation of arylsulfatases Sts Arsl Arsk Arsa Arsj Arsi Arsg Sumf1 Arsb Sumf2 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 96%10222233 IGF1R signaling cascade Irs2 Pik3r4 Pdpk1 Frs2 Klb Irs1 Trib3 Fgf2 Fgf1 Fgf4 Igf1r Fgf3 Fgf6 Fgf5 Fgf8 Fgfr3 Fgf7 Fgfr4 Fgf9 Fgfr1 Igf2 Fgfr2 Fgf16 Them4 Igf1 Pde3b Tlr9 Fgf17 Pik3ca Shc1 Fgf18 Fgf19 Gab2 Fgf10 Akt2 Pik3r1 Pik3cb Grb2 Pik3r2 Sos1 Ptpn11 Fgf20 Kl Fgf23 Flt3 Fgf22 Pik3c3 Gab1 KETONE BODY METABOLISM%REACTOME%R-RNO-74182.1 Ketone body metabolism Hmgcl Oxct2a Acss3 Bdh2 Bdh1 Oxct1 Hmgcll1 Acat1 Hmgcs2 Aacs DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 96%10221937 DNA strand elongation Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Rpa1 Rpa2 Gins2 Gins1 Gins4 Gins3 Rpa3 Lig1 Dna2 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME%R-RNO-9648025.1 EML4 and NUDC in mitotic spindle formation Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Pafah1b1 Zw10 Knl1 Eml4 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Ppp2r5b Dync1h1 Ppp2r5a Spc24 Spc25 Xpo1 Nuf2 Mad2l1 Cdca8 Incenp Dync1i2 Bub1b Ndel1 Ppp1cc Dync1i1 Cenpc Cenpa Aurkb B9d2 Ppp2r5e Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ranbp2 Ckap5 AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 96%10222495 Aquaporin-mediated transport Prkaca Prkacb Avp Aqp10 Aqp12a Myo5b Aqp1 Aqp4 Prkar1a Aqp3 Aqp2 Prkar1b Gng3 Gng5 Gng4 Gng7 Avpr2 Gng8 Gngt1 Prkar2a Prkar2b Gnb2 Gnb1 Gnb4 Gnb3 Rab11a Gnb5 Gng11 Aqp9 Aqp8 Gng10-ps1 Aqp7 Aqp5 Aqp11 Gnas Mip DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-RNO-8932504.1 DAG1 core M2 glycosylations Pomt1 Pomgnt1 Pomt2 Mgat5b Dag1 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450513.1 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Xrn1 Mapkapk2 Dis3 Tnpo1 Exosc9 Exosc8 Exosc5 Zfp36 Exosc4 Exosc7 Exosc6 Exosc1 Dcp2 Exosc3 Exosc2 Ywhab Dcp1a CELL DIVISION%REACTOME%R-RNO-68884.1 cell division Smc3 Plk1 Stag2 Stag1 Wapl Pds5b Kif23 Pds5a Nipbl Mau2 Smc1a Kif20a VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%10224715 VxPx cargo-targeting to cilium Exoc3 Exoc4 Rho Exoc5 Exoc6 Exoc1 Exoc2 Exoc7 Exoc8 Arf4 Cnga4 Cnga2 Gbf1 Rab11a Pkd1 Rab8a Asap1 Thoc2l Cngb1 Rab3ip RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-RNO-611105.1 Respiratory electron transport Cox5a Nfs1 Cox5b Higd1c Cox4i1 Cox4i2 Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Tmem186 Ndufaf3 Ndufaf2 Ndufaf1 Tmem126b Uqcrfs1 Nubpl Iscu Acad9 Etfdh Coq10a Coq10b Uqcrq Cyc1 Ndufv2 Slc25a18 Cox7a1 Ndufv1 Slc25a22 Cox7a2 Ndufv3 Uqcrb Fxn LOC120097699 Uqcrh Ndufc2 Ndufa12 Ndufa11 Ndufa10 Ndufs1 Ecsit Timmdc1 Ndufa13 Cox7a2l Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Ndufa6 Hscb Ndufa9 Ndufb8 Ndufs3 Ndufa8 Ndufb11 Ndufb10 Ndufb1 Lyrm7 Ndufb3 Rnf113a1 Hccs Uqcrc2 Uqcrc1 Etfb Lyrm4 Ndufb5 Etfa Lyrm2 Ndufb7 Dmac2 Dmac1 Ndufa3-ps3 Uqcr10 Ttc19 Cycsl2 Hspa9 Cox18 Tmem177 Cox20 Cycs Ndufa4 Mt-cyb Got2 Ndufa5 Cox6a1 Cox6a2 Cox6c2 Ndufab1 Cox6b1 Cox6b2 Mt-co3 Got1 Mt-co2 Mdh1 Cox8a Mdh2 Slc25a11 Cox8c Slc25a12 Slc25a13 Cox7b Cox7c Mt-co1 Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 TRAIL SIGNALING%REACTOME%R-RNO-75158.1 TRAIL signaling Tnfsf10 Casp8 Fadd Cflar CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-RNO-5660668.1 CLEC7A inflammasome pathway Casp8 Il1b Pycard Malt1 RHOH GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225179 RHOH GTPase cycle Mtr Pak6 Pak4 Slc1a5 Pak5 Dbt Tmem59 Zap70 Csk Vamp3 Jup Lck Osbpl11 Stom Uaca Rock2 Rab7a Nsfl1c Rock1 Fam91a1 Pak1 Cav1 Arhgdig Pak2 Arhgdib Slc4a7 Vcp Ralgapa1 Lamtor1 Tfrc Nipsnap2 Wdr11 Tuba1b Arhgdia Rhoh DARPP-32 EVENTS%REACTOME%R-RNO-180024.1 DARPP-32 events Ppp1ca Pde4d Ppp2cb Ppp2ca Prkar2a Prkar2b Pde4a Pde4b Ppp2r1b Prkaca Ppp2r1a Prkacb Cdk5 Prkar1a Prkar1b Ppp1r1b Ppp2r5d Pde4c REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 96%10224535 Regulation of TP53 Activity through Methylation L3mbtl1 Uba52 Prmt5 Ttc5 Ehmt1 Kmt5a Atm Ep300 Rps27a Chek2 Mdm4 Ubb Jmy Ubc Tp53 Smyd2 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 96%10225249 RSK activation Rps6ka1 Rps6ka6 Rps6ka2 Rps6ka3 NGF-STIMULATED TRANSCRIPTION%REACTOME%R-RNO-9031628.1 NGF-stimulated transcription Creb1 Chd4 Nab2 Egr2 Sgk1 Srf FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-RNO-8854050.1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Fbxl7 Psma7 Aurka Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%10224659 CHD chromatin remodelers Sf3b1 Sf3b3 Sf3b4 Sf3b5 Snrpepl2 Ctnnb1 Rbbp4 Rbbp7 H2ac18 Ssrp1 Hist1h2bq Hdac1 Wdr5 H2aj Snrpn Cherp Rbm17 Ddx46 H3-3b Hist3h2ba Ddx42 Cdc73 ENSRNOG00000068602 Chd3 Chd4 Mbd2 Mta1 H2bc18 Mta2 Mta3 Mbd3 H2az2 Cbx3 Chd8 H2bc4 Hist1h4m H2bc1 Gatad2a Gatad2b Hist1h2ai Puf60 Leo1 Ube2i Phf5a Smndc1 U2surp Snrpf Skic8 Snrpg Snrpb Hdac2 Nr2c2 Fam124b H2ab2 Zmynd8 Snrpa1 Ikzf3 Ikzf1 Zfp827 Zfp532 Adnp H2ac4 Cbx1 Ctr9 Paf1 Phf6 Zfp592 Ctcf Cdk2ap1 Snrpd1 Nr2f2 Chd1 Chd2 Chd5 Chd6 Chd7 Tcf19 ENSRNOG00000066901 Dhx15 Pwwp2a Snrpd3 Mbd3l1 Sf3a1 Mbd3l2 Sumo1 Sf3a2 Zfp687 Sf3a3 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-RNO-75035.1 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Ywhag Ccnb1 Ywhae Ccna1 Cdc25c Ccna2 Cdk1 Chek2 Ywhaq Ywhah Wee1 Sfn Ywhab Ywhaz DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-RNO-5693606.1 DNA Double Strand Break Response Rnf8 Nsd2 Rad50 Eya2 Eya1 Eya4 Babam1 Eya3 Babam2 Ubxn1 Brca1 Hist1h2bq Uimc1 Hist3h2ba Rps27a H2bc4 Hist1h4m Mapk8 H2bc1 Pias4 Ube2n Mre11 Ube2i Uba52 Kat5 Nbn Baz1b Chek2 Ube2v2 Bard1 Ubb Ubc Tp53 Kpna2 Atm Bap1 Tp53bp1 Apbb1 Kdm4b Kdm4a Brcc3 Abl1 Smarca5 ENSRNOG00000066901 Ppp5c Herc2 Rnf168 Sumo1 ABRAXAS1 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 96%10223947 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Bad Bcl2l1 Bcl2l11 Bid Pmaip1 G1 PHASE%REACTOME DATABASE ID RELEASE 96%10221949 G1 Phase Ppp2r2a Ppp2cb Ccnd1 Ppp2ca Uba52 Tfdp2 Tfdp1 Cks1b Cdk7 Cdk6 Rbl2 Rbl1 Mnat1 Ubb E2f1 Ubc E2f2 E2f3 E2f4 E2f5 Cdkn1b Jak2 Rb1 Cdkn1c Ppp2r1b Ppp2r1a Lyn Cul1 Ccnh Cdk2 Src Ccne1 Rps27a Ccne2 Ppp2r3b Cdkn2b Cdkn2d Abl1 Skp2 Cdk4 Skp1 Ccnd2 Ptk6 Ccnd3 KETONE BODY CATABOLISM%REACTOME%R-RNO-77108.1 Ketone body catabolism Oxct2a Bdh1 Oxct1 Acat1 CELL CYCLE, MITOTIC%REACTOME%R-RNO-69278.1 Cell Cycle, Mitotic Ywhag Rbbp4 Mapk3 Emd Ppp2r5b Ppp2r5a Fbxw11 Ppp1cc Ppp1cb Ppp2r5e Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Kpnb1 Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Tuba1c Tubal3 Nme7 Rcc1 Cep152 Tuba4a Chmp2b Tubgcp2 Cc2d1b Prkcb Haus4 Spast Tubb2b Haus5 Tubb2a Haus6 Ist1 Pcnt Hdac8 Sfi1 Chmp3 Vrk1 Haus1 Tubgcp6 Chmp7 Tubgcp5 Chmp6 Tubgcp4 Lmna Vps4a Tubgcp3 Sirt2 Cep250 Tuba8 Cep290 Cep78 Chmp4c Cep76 Tuba3b Cep72 Chmp4bl1 Tubb6 Cep164 Cep70 Tubb3 Cpap Tubb1 Tubb5 Banf1 Plk4 Ran Odf2 Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Cdk11b Akt3 Akt2 Akt1 Optn Ccne1 Ccne2 Ppp2r3b Cdkn2b Cdkn2d Cdc25a Orc4 Orc6 Orc1 Rab1b Orc3 Kif23 Orc2 Cdt1 Gmnn Ptk6 Cdc7 Chmp2a Kif20a Cdc6 Ppp2r2a Mcm7 Mcm8 Dbf4 Dyrk1a Tfdp2 Tfdp1 Cks1b Cables1 Lin52 Rbl2 Lin54 Rbl1 Mcm3 Mcm4 Mcm5 Mcm10 Mcm2 Pole3 Pole2 Pole4 Lin9 Rpa1 Rpa2 Wee1 Lin37 Rpa3 E2f1 E2f2 E2f3 E2f4 E2f5 Cdkn1b Pole Cdkn1c Ywhae Lbr Rab1A Rab8a Akap9 Lyn Src Eml4 Wapl Numa1 Pds5b Pds5a Cdca5 Dna2 Ube2i Firrm Jak2 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Kmt5a Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Sumo1 Fbxl7 Phf8 Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Ajuba B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Nup93 Cenpo Cenpn Nup50 Cenpm Mis12 Cenpl Cenpk Nup35 Cenpi Nup54 Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Nup58 Rangap1 Nup37 Pkmyt1 Clip1 Pom121 Sgo2 Nup205 Sgo1 Nup107 Cdc25c Sec13 Kif2a Kif2b Nup188 Kif2c Dync1li2 Tpr Pmf1 Nup160 Dync1li1 Ahctf1 Rae1 Mapre1 Ndc1 Dynll1 Dynll2 Kntc1 Nup85 Nup42 Ndc80 Nup62 Nup43 Nup88 Birc5 Aaas Ercc6l Ccnb2 Ranbp2 Ckap5 Csnk1e Nup214 Spdl1 Nup133 Nup210 Nup155 Bub1 Nup153 Itgb3bp Gtse1 Zwilch Nek9 Ctdnep1 Cnep1r1 Lpin3 Gins2 Lpin2 Gins1 Gins4 Gins3 Phlda1 Ofd1 Esco1 Esco2 Tuba1b Ppp1r12b Ppp1r12a Vrk2 Mastl Arpp19 Hsp90ab1 Ankle2 Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Aurka Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Cdc14a Psmd7 Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 Mapk1 Actr1a Ppp2cb Ppp2ca Dctn1 Dctn2 Prkaca Prkca Ppp2r5d Prkar2b Gorasp1 Ppp2r1b Ppp2r1a Nipbl Ncapd2 Mau2 Ncapg Smc4 Ncaph Smc2 Csnk1d Ccp110 Golga2 Tpx2 Tp53 Lig1 Fen1 Set H2ab2 Rab2a Blzf1 Espl1 Ncaph2 Ccnh Ncapd3 Fkbpl H2ac4 Ncapg2 Gorasp2 Mcph1 Smc3 Bora Foxm1 Ppme1 Lcmt1 Mis18bp1 Hjurp Abl1 ENSRNOG00000066901 Cdc25b Obi1 Ccnd2 Ticrr Ccnd3 Ccnd1 Stag2 Stag1 Cdk7 Cdk6 H2ac18 Csnk2a2 Csnk2a1 Mnat1 Hist1h2bq Smc1a Hdac1 Csnk2b H2aj Hist3h2ba ENSRNOG00000068602 H2az2 H2bc4 Hist1h4m H2bc1 Hist1h2ai Rbx1 Cdk4 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%10223249 Adaptive Immune System Ywhag Suz12 Ddost Eed Gsk3b Cd274 Os9 Pdcd1 Rnf5 Sel1l Prkcq Magt1 Rbbp4 Rbbp7 Mib2 Rasgrp1 Pdcd1lg2 Prkab2 Prkab1 Ube2d3 Ube2d2 Sptbn2 Nras Grb2 Fyn Rap1a Kras Sos1 Rap1b Hras Ikbkb Kbtbd7 Cd40lg Traf6 Cd40 Ppp2r5b Ikbkg Ppp2r5a Map3k8 Map3k7 Ube2n Nfkb1 Cd36 Fbxw11 Rela Ppp2r5e Map3k14 Btla Ppp3ca Ppp3cb Itk Ube2j2 Nfatc1 Nfatc3 Nfatc2 Ppp3r1 Grap2 Ripk2 Nfkbib Prkcb Nfkbia Kif4b Ap2s1 Kif4a Tab2 Dnm3 Ap2a2 Ap2a1 Chuk Ap2b1 Lat Sh3gl2 Itgav Ywhab Osbpl1a Csk Itgb1 Trib3 Cd81 Kif26a Them4 Kif11 Kif15 Kif5a Kif5b Akt3 Akt2 Akt1 Cd19 Sh3kbp1 Kif22 Kif23 Ap1b1 Kif20a Klc1 Ap1m2 Ap1m1 Kifap3 Vamp8 Ap1s3 Klc4 Ap1s2 Klc3 Klc2 Ap1g1 Kif3b Kif3c Cxadr Plcg2 Rab7a Fkbp1a Mtor Prkg1 Pik3r6 Mlst8 Lrr1 Nedd4 Rnf220 Jaml Fbxl21 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb Vamp3 RT1-M6-2 Sh3rf1 Trim11 Ube2l6 Mex3c Cdc34 B2m Dcaf1 Itga4 Rnf126 Ubac1 Lnpep Atg7 Rnf114 Rnf115 Rnf111 RT1-M10-ps1 RT1-M10-ps5 Snap23 Siah1 Dzip3 Itpr3 Itpr2 Mkrn1 Ube2g2 Itpr1 Pak1 Ube2g1 Rnf138 RT1-N3 Pak2 Rnf130 Lyn Kbtbd8 Yes1 Fbxw4 Src Fbxw5 Fbxw7 Gan Fbxw8 Fbxw9 Anapc13 Itgal Det1 Fbxw2 Klhl5 Rbck1 Arih2 Rlim Klhl3 Itgb2 Klhl2 Ube4a Lcp2 Spsb2 RT1-M1-2 Trim9 Spsb1 Trip12 Wwp1 RT1-M1-5 Spsb4 Rt1-ec3 Calr Lrsam1 Eloc Huwe1 Elob Ube2j1 Kctd7 Ube2u Kctd6 Ncf1 Zap70 Ncf2 RT1-Db2 Cd3g Ube2w Ncf4 Cd247 RT1-Db1 Ube2m Cd3e Ube2k Cd3d Rnf182 Trav19 Trem1 Ube2o Ltn1 AC109737.1 Ube2v2 Pdia3 Cd4 RT1-Ha Ube2b Mgrn1 Lck Ube2f Ptpn22 RT1-Ba Trpc1 Ube2a RT1-Bb Stim1 Fbxo10 ENSRNOG00000065955 Fbxo11 Trbv16 Fbxo15 RT1-Da Tap2 Tap1 Fbxo17 Nectin2 Lmo7 Rnf41 Pvr Raf1 Mylip Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Fbxo21 RT1-M5 Fbxo22 Ubox5 Ubr1 Rnf19a Ubr2 Ctsd Glmn Ubr4 RT1-M2 Fbxo27 Uba5 Uba6 Trim69 Uba7 Fbxw17 Herc2 Cd74 Trim71 Klhl25 Rnf19b Ube2e3 Lgmn Ube2e2 Klhl21 Btbd6 Hace1 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Psme2 Fbxl7 Psme1 Lonrf1 Psmb9 Zbtb16 Psmb10 Hspa5 Psmb8 Sell Uba1 Cyba Cybb Uba3 Cul2 Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Inpp5d Klhl41 Canx Pik3ca Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Ptpn6 Pja2 Pja1 Arel1 Trim63 Rnf144b Pik3r1 Fbxo2 Pik3cb Asb12 Asb14 Asb13 Pik3r2 Asb16 Pik3r3 Asb15 Asb18 Pik3cd Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Herc6 Fbxo9 Kif18a Trim21 Pik3r5 Vhl Dync1h1 Pik3cg Tapbp Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Dync1i2 Trim36 Trim32 Dync1i1 Trim41 Unkl Erap1 Asb9 Asb7 Asb6 Asb5 Rnf25 Asb4 AABR07044308.1 Rchy1 Asb1 Lnx1 Cenpe Sec13 Kif2a Kif2b Kif2c Dync1li2 Dync1li1 Smurf1 Dynll1 Dynll2 Ywhaz Pdpk1 Kif3a Cd207 Mrc2 Mrc1 Cd101 Pag1 Ptprc Fyb1 Prkn Stub1 Sar1b Ube2l3 Smurf2 Dapp1 Cd22 Blnk Cd79a Cd79b Ctsb Cbll1 Ctss Dnm2 Rapgef4 Rapgef3 Rasgrp2 Btn1a1 Btnl9 Btn2a2 Cd209a Btnl2 Ppl Xdh Btk C3 Plcg1 Racgap1 Trem2 Rac1 Pak3 Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Btrc Psma7 Nck1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Cdc16 Rnf123 Siah2 Keap1 Actr1a Siglec10 Ppp2cb Ppp2ca Klrk1 Dctn1 Dctn2 Prkaca Icoslg Prkacb Dctn4 Calm3 Ppp2r5d Sec23a Ppp2r1b Ppp2r1a Ctsc Arf1 Sec31a Pten Actr10 Sec24d Sec24c Sec24b Sec24a Ctsh Malt1 Bcl10 Nfkbie Rel H2ab2 H2ac4 Actr1b Siglec1 Siglec5 Siglec8 LOC100910497 Slamf6 Slamf7 Hcst Kir3dl1 ENSRNOG00000066901 Pilrb2l4 Ctla4 Ifitm1 Ifitm2 Socs1 Ifitm6 Pilrb1l3 Rap1gap Lag3 Pilrb-ps7 Cd160 Ccnd1 ENSRNOG00000070312 Pianp Cd226 Ifitm3-ps2 LOC134481331 Ifi30 Lair1 Kmt2a Rilp Treml2 Kmt2c Treml4 H2ac18 Cd200 Ctse Ctsf Cd1d Csnk2a2 Ctso Ctsk ifitm3 Ctsl Cd34 Csnk2a1 Sipa1 Cd200r1l LOC120093164 Rap1gap2 Cd96 Hist1h2bq RT1-DOa RT1-DOb Crtam Cd8b Wdr5 Cd8a Ash2l Cd300le Cd300ld Csnk2b RT1-DMb Cd300lg H2aj Cd300lf Klrb1a Clec4g Clec2e H3-3b Hist3h2ba ENSRNOG00000068602 Itch Vav1 Ptpn11 H2bc18 ENSRNOG00000069193 H2az2 Rbbp5 AABR07065813.1 ENSRNOG00000062915 H2bc4 Igll1 Hist1h4m ENSRNOG00000065191 H2bc1 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 Hist1h2ai ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Pik3ap1 Fcgr2 Cd28 Syk Icos Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 Rictor Cd86 ENSRNOG00000066971 Cd80 ENSRNOG00000063341 ENSRNOG00000065283 Prr5 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Trat1 Igkvl13 Mapkap1 AABR07065812.2 ENSRNOG00000063707 Madcam1 Fcgr1a ENSRNOG00000067679 Ap2m1 ENSRNOG00000070832 ENSRNOG00000064041 Clta Itgb7 ENSRNOG00000064481 Icam1 Ctsa ENSRNOG00000065690 ENSRNOG00000064085 Icam5 ENSRNOG00000066904 Cltc Icam4 ENSRNOG00000063713 Icam2 ENSRNOG00000062820 Dnm1 Rnf185 ENSRNOG00000064886 Prkaa1 ENSRNOG00000064490 Vcam1 ENSRNOG00000066072 Derl3 Prkaa2 AABR07065781.1 Derl2 ENSRNOG00000069901 Stt3b ENSRNOG00000067603 Rbx1 ENSRNOG00000066431 ENSRNOG00000068499 Erlin2 Spop ENSRNOG00000069940 Socs3 Erlin1 ENSRNOG00000067643 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Tmem258b Tusc3 Cdc42 Cdk4 Cul3 Ezh2 Erlec1 B3gnt3 Dad1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-RNO-186712.1 Regulation of beta-cell development Foxo1 Akt3 Akt2 Akt1 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 96%10222025 Glycogen metabolism Phkg1 Gaa Gbe1 Phkg2 Agl Pygl Pygm Phkb Ppp1r3c Gys1 Akr1e2 Phka1 Phka2 Gyg1 Pgm1 Calm3 Ugp2 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 96%10223229 Metabolism of folate and pterines Mthfd1 Mthfd2 Folr2 Mthfd2l Dhfr Slc19a1 Aldh1l1 Aldh1l2 Shmt2 Fpgs Mthfs Mthfr Slc25a32 Slc46a1 Mthfd1l Shmt1 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223893 IL-6-type cytokine receptor ligand interactions Lifr Crlf1 Jak2 Cntf Cntfr Clcf1 Ctf1 Il31ra Lif Il11 Tyk2 Osmr Il11ra1 Il6st Osm OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 96%10224631 Oxidative demethylation of DNA Tdg SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 96%10224257 Synthesis of PS Ptdss1 Ptdss2 CIRCADIAN CLOCK%REACTOME%R-RNO-9909396.1 Circadian clock Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Per2 Per1 Per3 Psmb5 Psmb4 Psmb7 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225175 RHOJ GTPase cycle Ophn1 Rhoj Arhgap32 Pik3r1 Arhgap35 Pik3r2 Prex1 Ocrl Trio Depdc1b Arhgap5 Dock8 Syde1 Arhgap1 Arhgap21 Arhgap26 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME DATABASE ID RELEASE 96%10223765 SLC-mediated transport of inorganic anions Slc4a10 Slc26a6 Slc4a2 Slc26a4 Slc4a4 Slc34a1 Slc26a3 Slc4a3 Slc26a9 Slc26a2 Slc4a5 Slc26a1 Slc4a8 Slc26a7 Slc4a9 Slc34a2 Slc4a1 Slc26a11 Slc12a1 Slc5a8 Slc12a4 Slc12a5 Slc12a2 Slc12a3 Slc12a6 Slc12a7 Slc34a3 Slc13a4 Slc13a1 Slc4a7 Slc5a5 Slc20a2 Ahcyl2 Slc20a1 Slc17a1 SENSORY PERCEPTION%REACTOME DATABASE ID RELEASE 96%10222207 Sensory Perception Akr1c18 Akr1c12l1 Akr1c19 Akr1c21 Calm3 Nmt1 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Akr1c9 Gngt1 Itpr3 Gnat3 Apoc2 Apoa1 Gnb1 Apoc3 Apoa2 Gnb3 Apoe Gnb5 Apoa4 Apob Lrp1 Sdc4 Sdc3 Sdc2 Lpl Gpihbp1 Lrp8 Lrp2 Lrp10 Plb1 Lrp12 Ttr Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Bco2 Bco1 Rdh12 Gpc6 Clps Cyp4v2 Stra6 Pnlip Rpe65 Akr1b10 Rbp4 Rbp3 Myo7a Apom Rbp2 Rlbp1 Rbp1 Sdc1 Lrat Tas2r119 Opn1sw Tas2r39 Tas2r38 Tas1r2 Tas1r1 Fnta Tas2r120 Fntb Tas1r3 Cngb1 Tas2r16 Tas2r13 Tas2r136 Tas2r140 Tas2r105 Tas2r107 Tas2r4 Tas2r3 Tas2r7 Scnn1a Dhrs3 Scnn1b Scnn1g Rgs9bp Ppef1 Pde6g Rgs9 Grk1 Grk4 Nmt2 Metap1 Metap2 Camkmt Rdh11 Gucy2e Rdh10 Sag Gucy2f Cnga1 Pde6a Pde6b Gnat1 Rcvrn Guca1b Guca1a Opn1mw Awat2 Rho Agrn Tas2r40 Tas2r41 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 96%10222189 Dimerization of procaspase-8 Ripk1 Tnfsf10 Casp8 Fas Fadd Faslg Traf2 Tradd Cflar ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-RNO-5624958.1 ARL13B-mediated ciliary trafficking of INPP5E Arl13b Pde6d Inpp5e G2 M TRANSITION%REACTOME%R-RNO-69275.1 G2 M Transition Ywhag Actr1a Ppp2cb Ppp2ca Gtse1 Dctn1 Dctn2 Prkaca Rab8a Akap9 Phlda1 Ofd1 Prkar2b Ppp2r1b Ppp2r1a Ppp1r12b Ppp1r12a Csnk1d Ccp110 Fbxw11 Ppp1cb Nedd1 Mzt2b Tpx2 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Tp53 Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Nme7 Hsp90ab1 Cep152 Tuba4a Tubgcp2 Haus4 Haus5 Haus6 Pcnt Ccnh Sfi1 Haus1 Fkbpl Tubgcp6 Tubgcp5 Tubgcp4 Tubgcp3 Cep250 Cep290 Bora Cep78 Cep76 Foxm1 Cep72 Ppme1 Lcmt1 Cep164 Cep70 Mis18bp1 Hjurp Cpap Cdc25b Tubb5 Obi1 Plk4 Odf2 Ticrr Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Cdk11b Cdk7 Fbxl7 Mnat1 Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Hsp90aa1 Optn Psma2 Psma1 Rps27a Psmd12 Ppp2r3b Psmd11 Pafah1b1 Psmd14 Cdc25a Psmd13 Ccnb2-ps2 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ppp2r2a Dync1h1 Ccnb1 Psmb1 Psmb3 Xpo1 Psmb2 Uba52 Dync1i2 Btrc Psma7 Aurka Ajuba Psmc5 Psmc2 Psmc1 Nde1 Psmc4 Psmc3 Wee1 Fzr1 Ubb Ubc Nek2l1 Psmb6l1 Clasp1 Psmd7 Ywhae Psmd6 Pkmyt1 Psmd8 Plk1 Psmd2 Sgo1 Cdc25c Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdk1 Mapre1 Dynll1 Ccnb2 Ckap5 Csnk1e GAP JUNCTION TRAFFICKING%REACTOME%R-RNO-190828.1 Gap junction trafficking Gja10 Gjc1 Gjd2 Gjd4 Gjb2 Gjd3 Gjb1 Gjc2 Gja3 Gjb4 Gjb3 Gja5 Gjb6 Gjb5 Gja4 Gja8 Dnm2 Ap2m1 Gja1 Clta Cltb Myo6 Cltc Dab2 Dnm1 PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 96%10222161 Pyrimidine salvage Tymp Cda Upp1 Dck Upp2 Pudp Tk2 Uck1 Uck2 DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 96%10225523 Degradation of CRY and PER proteins Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Per2 Per1 Per3 Psmb5 Psmb4 Psmb7 REGULATION OF IFNG SIGNALING%REACTOME%R-RNO-877312.1 Regulation of IFNG signaling Ifngr2 Ifngr1 Jak2 Stat1 Pias1 Ptpn2 Socs1 Socs3 Sumo1 Ifng G2 M CHECKPOINTS%REACTOME%R-RNO-69481.1 G2 M Checkpoints Ywhag Gtse1 Blm Wrn Dna2 Pias4 Ube2n Mre11 Kat5 Nbn Hus1 Atrip Chek1 Chek2 Ube2v2 Rad9a Rad9b Bard1 Top3a Tp53 Clspn Rad17 Rfc5 Rfc3 Rfc4 Atm Rfc2 Atr Tp53bp1 Exo1 Rmi2 Rmi1 Brip1 Brcc3 ENSRNOG00000066901 Ywhab Herc2 Rnf168 ABRAXAS1 Rnf8 Rhno1 Nsd2 Rad50 Babam1 Babam2 Topbp1 Rbbp8 Brca1 Hist1h2bq Uimc1 Rad1 Psma4 Ccna1 Psma3 Ccna2 Hist3h2ba Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Cdc25a Psmd13 Ccnb2-ps2 Orc4 Orc6 Orc1 Orc3 Orc2 Sfn H2bc4 Psmb5 Hist1h4m Psmb4 H2bc1 Cdc7 Psmb7 Cdc6 Psmb6 Ccnb1 Mcm7 Psmb1 Mcm8 Psmb3 Dbf4 Psmb2 Uba52 Psma7 Mcm3 Mcm4 Mcm5 Psmc5 Mcm10 Psmc2 Mcm2 Psmc1 Psmc4 Psmc3 Rpa1 Rpa2 Wee1 Ubb Rpa3 Ubc Psmb6l1 Psmd7 Ywhae Psmd6 Pkmyt1 Psmd8 Psmd2 Cdc25c Psmd1 Adrm1 Cdk2 Cdk1 Ywhaq Ywhah Ccnb2 Ywhaz CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 96%10223009 Chylomicron clearance Ldlrap1 Lipc Apoe Apob Ldlr CELLULAR RESPONSES TO STRESS%REACTOME%R-RNO-2262752.1 Cellular responses to stress Suz12 Cox5a Cox5b Eed Gsk3b Hmox1 Rbbp4 Rbbp7 Ube2d3 Ube2d2 Cox4i1 Cox4i2 Mapk3 Mapk9 Mapk7 Mapk8 Cat Fos Rps6ka3 Rps6ka1 Rps6ka2 Map2k7 Map2k6 Lamtor3 Lamtor2 Mapkapk3 Mapk14 Jun Mapkapk2 H1-1 H1-0 Map2k3 H1-5 H1-4 H4f3 Mapk10 Mapk11 Creb3l3 Crebrf Gpx2 Gpx1 Ncoa2 Atp6v0b Atp6v1g3 Atp6v0e2 Atp6v1c2 Ern1 Atp6v1c1 Terf2 Atp6v0c Acd Terf1 Terf2ip Atp6v1e2 Tinf2 Atp6v1e1 Pot1 Tcirg1 Txnrd1 Atp6v1a Atp6v1b2 Akt3 Atp6v0d2 Akt2 Atp6v0d1 Akt1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Gsr Atp6v1g1 Atp6v1f Ccne1 Atp6v1d Ccne2 Cdkn2b Cdkn2d Hspa8 Rpa1 Rpa2 Rpa3 Cdkn1b Ywhae Rptor RragB Mtor Rheb Slc38a9 Lamtor5 Akt1s1 Lamtor4 Rraga Lamtor1 Rragc Rragd Mlst8 Map1lc3b Ep400 Asf1a Cabin1 Hira Ubn1 Hmga2 Hmga1 Gstp1 Map3k5 Tnik Mink1 Map4k4 Camk2g Camk2d Camk2b Camk2a Oma1 Mre11 Eloc Kat5 Elob Nbn Ncf1 Ncf2 Ncf4 Hsph1 Dnajc2 Cryab Hikeshi Hspa14 Hspa13 Rps19bp1 Hsbp1 St13 Hspa12b Hspa12a Bag5 Bag3 Bag2 Bag1 Hspb8 Dnajb6 Hspa9 Atm Hspa4 Sirt1 Clec1b Rad50 Ehmt1 Kdm6b Hspa5 Cyba Cybb Cul2 Sod1 Eif2s3 Med1 Eif2s2 Eif2s1 Trim21 Vhl Dync1h1 Xpo1 Dync1i2 Dync1i1 Ajuba Mbtps1 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Tgs1 Nup188 Dync1li2 Tpr Nup160 Dync1li1 Rae1 Ndc1 Dynll1 Dynll2 Nup85 Mdm4 Nup42 Nup62 Nup43 Nup88 Ly96 Aaas Ranbp2 Nup214 Tlr4 Nup133 Nup210 Nup155 Nup153 Fabp1 Blvrb Hmox2 Blvra Abcc1 Hsf1 Dnaja1 Hspa1b Sirt3 Hspa1a Alb Arnt Apoa1 P4hb Nploc4 Apob Stip1 Pgrmc2 Eif2ak1 Yme1l1 Dele1 Stoml2 Phb2 Txn Hsp90ab1 Cycsl2 Cycs Sod2 Prkci Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Eef1a1 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp1 Psmb5 Psmb4 Psmb7 Rxra Psmb6 Psmb1 Psmb3 Pgr Psmb2 Uba52 Anapc10 Tbl1x Ube2d1 Anapc16 Btrc Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Hdac3 Fzr1 Ubb Hspa1l Anapc7 Tbl1xr1 Slc46a1 Ubc Foxo3 Ube2e1 Psmb6l1 Psmd7 Rb1 Psmd6 Fkbp4 Hspa2 Psmd8 Fkbp5 Ptges3 Psmd2 Mt-co3 Mt-co2 Ncor2 Psmd1 Adrm1 Carm1 Cul1 Cdk2 Cdc16 Egln1 Egln2 Egln3 Epas1 Mapk1 Hif3a Wtip Mt-co1 Limd1 Ar Hif1a Keap1 Actr1a Ufd1 Dctn1 Dctn2 Dctn4 Higd1c Cited2 Mul1 Sesn2 Sesn1 Cox7a1 Cox7a2 Actr10 Cox7a2l Hba1 Hbb Tp53 H2ab2 H2ac4 Ring1 ENSRNOG00000066901 Phc2 Nr3c2 Cbx6 Nr3c1 Phc1 Cbx4 Cbx2 Esr1 Phc3 Crebbp Ndufa4 Cdk6 H2ac18 Ppara Sin3a Sin3b Bmi1 Prdx2 Prdx5 Hist1h2bq Srxn1 Prdx1 Nfe2l2 H2aj H3-3b Hist3h2ba Sqstm1 Ep300 Rnf2 ENSRNOG00000068602 Smarcd3 Cox6a1 Cox6a2 Txn2 H2bc18 Bach1 H2az2 H2bc4 Hist1h4m H2bc1 Cox6c2 Hist1h2ai Cox6b1 Prdx3 Cox6b2 Atf6 Prdx6 Nprl3 Nprl2 Wdr59 Nox4 Mios Depdc5 Wdr24 Erf Gpx3 Gpx6 Gpx5 Gpx8 Gpx7 Cebpb Fnip1 Fnip2 Samtor Hm13 Hif1an Eif2ak3 Id1 Itfg2 Castor2 Prkaa2 Castor1 Nudt2 Cox8a Ubxn7 Rbx1 Ets1 Cox8c Ets2 Ero1a Szt2 Vcp Atf6b Cox7b Txnrd2 Dnaja2 Cox7c Dnaja4 Kics2 Sod3 Flcn Ccs Sh3bp4 Cdk4 Dnajb1 Cul3 Mapkapk5 Ezh2 NADPH REGENERATION%REACTOME%R-RNO-389542.1 NADPH regeneration Idh1 Aco1 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223391 Serotonin and melatonin biosynthesis Tph1 Ddc Asmt Aanat Tph2 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-RNO-6814848.1 Glycerophospholipid catabolism Gde1 Pnpla6 Enpp6 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 96%10223847 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Creb1 Rps6ka1 Rps6ka6 Rps6ka2 Rps6ka3 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222487 PKA activation in glucagon signalling Prkar1a Prkar2a Prkar1b Prkar2b Prkaca Prkacb RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-RNO-6807505.1 RNA polymerase II transcribes snRNA genes Ice2 Cdk7 Ell Ccnk Ccnt2 Phax Ell2 Ssu72 Ell3 Srrt Rprd1a Taf9 Rprd1b Taf11 Taf13 Pou2f2 Tbp Gtf2a1 Gtf2a2 Gtf2b Pcf11 Taf8 Taf6 Taf5 Gtf2e1 Polr2c Polr2a Polr2b Gtf2e2 Polr2g Polr2h Polr2e Polr2f Polr2i Polr2j Ncbp2 Ncbp1 Ints4 Ints5 Supt4h1 Ints6 Gtf2f2 Gtf2f1 Ints7 Ints8 Snapc3 Ints9 Snapc4 Ints13 Snapc1 Ints14 Ints1 Snapc2 Ints2 Ints11 Ints3 Ints12 Ints10 Zc3h8 Rprd2 Cdk9 Nabp1 Pou2f1 Nabp2 Rpap2 Sp1 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 96%10222463 Signaling by GPCR Rgs3 Rgs1 Rgs8 Rgs7 Pcp2 Gpsm3 Gpsm2 Gpsm1 Rgs21 Rgs18 Prkcq Rgs19 Rgs13 Rgs14 Gnat2 Rgs12 Ccr1l1 Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 Creb1 Hbegf Mapk3 Nras Grb2 Kras Sos1 Hras App Mapk7 Rps6ka3 Rps6ka1 Rps6ka2 Egfr Rasgrf2 Gna12 Itgb1 Pde3b Akt3 Akt2 Akt1 Prkch Prkce Grk3 Mgll Pik3r6 Dgka Dgkb Abhd6 Dgkd Dgke Dgkg Dgkh Dgki Dgkk Dgkq Dgkz Itpr3 Itpr2 Itpr1 Pak1 Pde10a Daglb Src Rhoa Ngef Trpc7 Trpc3 Dagla Pde11a Arrb2 Arrb1 Lhb Cga Pde3a Pde7a Grk5 Grk6 Pde8a Pde8b Rhob Agt Npffr1 Npffr2 Npff Abhd12 Hcrtr2 Hcrtr1 Qrfprl Qrfpr Qrfp Hcrt Pde2a Pik3ca Shc1 Pik3r1 Pik3r2 Pik3r3 Pik3r5 Pik3cg Pdpk1 Ednrb Ednra Plxnb1 Sct Rrh Ptgdr Htr4 Apln Trhr Tas2r39 Htr6 Oprd1 Htr7 Tas2r38 C3ar1 Crhbp Galr2 Galr3 Galr1 Cmklr1 Avpr2 Sstr5 Sstr4 Sstr3 Kel Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Rxfp1 Htr5a Ghrhr Tbxa2r Gpr183 Ppbp Fpr1 Btk Gnrh1 Tas1r2 Tas1r1 Nmbr Fpr2 Ccr10 Tas1r3 C3 Vipr2 Nln Vipr1 C5 Ptgfr Pnoc Tas2r16 Tas2r13 Rhoc Ppy Tas2r135 Tas2r136 Nmb Oxtr Lpar6 Xcr1 Gpr18 Grpr Gpr17 Nms Tas2r140 Nmu Tas2r145 Cckar Npbwr1 Fshb Gpbar1 Nmur2 Gnrhr Adm Nmur1 Ntsr2 Ntsr1 Tas2r4 Ramp1 Tas2r3 Rock2 Arhgef7 Brs3 Ptger4 Rock1 Tas2r7 Gabbr1 Ptger2 Ptger3 Fshr Gabbr2 Ptger1 Ccr9 Ccr8 Ccr7 Ucn2 Mchr1 Ccr6 Ucn3 Ccr5 Crhr2 Ccr4 Crhr1 Ccr3 Gpr132 Edn1 Gast Edn2 Edn3 Cckbr Gipr Mtnr1b Agtr1 Agtr2 F2 Gpha2 Gpr37 Calcrl Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Pth1r Taar3 Taar2 Avp Taar5 Rgr Taar1 Npb Gpr143 Grp Opn1mw Pth Kiss1r Gcgr Sctr Ccl19 Ccl17 Gphb5 Nps Mc4r Ccl11 Ccl12 Ptafr Npw Npy Ghrh Ptgdr2 Rho Mmp3 Pth2r Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Gpr4 Gcg Ptgdrl Ccl27 Npsr1 Plcb4 Prok1 Plcb3 Ramp3 P2ry10 Mapk1 Pla2g4a Ramp2 Pdyn Mc3r Plcb2 P2ry13 Plcb1 P2ry12 Ccl20 Ppp1r1b Gpr55 Gng10-ps1 Adcy3 Ccl21 Adcy4 P2ry14 Adcy1 Adm2 Adcy2 Mcf2 F2rl1 Tas2r40 Camkk1 Adcy7 Fpr2l1 Tas2r41 Camkk2 Adcy8 Cd55 Ppp1ca F2rl2 Adcy5 F2rl3 Adcy6 Hcar1 Ppp2cb Prokr2 Ppp2ca Adra2b Adcy9 Hcar2 Prokr1 Pde4a Cxcr1 Pde4b Cxcr2 Prkaca Cxcr3 Prkacb Prkcg Npy1r Prkcd Xk Gpr65 Oprm1 Gpr68 Gnai2 Gnai1 Cxcr4 Prkca Cxcr5 Iapp Gnai3 Oprl1 Gna11 Camk4 Adrb2 Prkar1a Adrb1 Adra1b Gna14 Prkar1b Adrb3 Calm3 Adra1a Ppp2r5d Adra1d Lhcgr Gng3 Uts2 Grk2 Mc5r Gnal Prlh Pomc Tacr1 Gng5 Tacr3 Gng4 Tacr2 Pde4c Anxa1 Gnaq Cxcl11 Gng7 Hebp1 Pde4d Calcr Gng8 Gngt1 Cxcl12 Casr Gnat3 Prkar2a Cxcl10 Prkar2b C5ar2 F2r Ppp2r1b Ppp2r1a C5ar1 Ffar3 Cdk5 Pde1b Aplnr Bdkrb2 Pde1c Ffar1 Gnb2 Bdkrb1 Gnb1 Ffar2 Pde1a Nts Gnb4 Kng1 Gnb3 Calcb Gnb5 Chrm1 Gng11 Calca Hrh1 Chrm3 Chrm2 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Gnas Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Ccrl2 Gper1 Oxgr1 Adra2a Opn5 Adora2b Sucnr1 Pyy Adora2a Adora1 Adra2c Adora3 Rln3 Ltb4r2 Rln1 Cxcl16 Cxcl13 Ucn Tas2r119 Opn1sw Prlhr Oxt Ece1 Ece2 Trh P2ry2 Npy5r Adcyap1 Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Ffar4 Grm8 Htr2a Ghrl Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Insl3 Gip Ptgir Psap Htr1d Htr1f Glp1r Crh Tas2r120 Xcl1 Htr1b Htr1a Kiss1 Adgre5 Adgre1 Pth2 Tshr Glp2r Ccl9 P2ry6 Cxcl9 Ccl7 P2ry4 Ccl6 Ccl5 P2ry1 Ccl4 Ccl3 Ccl1 Cxcl1 Cxcl2 Cxcl3 Pthlh Cxcl5 Uts2b Tas2r105 Tas2r107 Gpr37l1 Ackr3 Ackr4 Cck Cnr1 Ackr2 Cnr2 Uts2r Taar8c Sst Oprk1 Vip Tshb Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 Sos2 Kalrn Rgs9 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Gnat1 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Rgs20 Rgs17 Rgs16 Gnaz Cdc42 Rgsl1 Ghsr Rgs4 Rgs5 Rgs2 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10224939 COPI-mediated anterograde transport Actr1a Ins2 Dctn1 Dctn2 Cog1 Cog2 Rab1A Dctn4 Cog3 Cog4 Arfgap3 Arfgap2 Cog5 Arfgap1 Cog6 Cog7 Cog8 Napa Nsf Napb Ank1 Napg Tmem115 Kdelr2 Kdelr3 Spta1 Copa Bet1l Gorasp1 Sptb Sptbn1 Sptbn2 Kdelr1 Arf4 Arf3 Sptan1 Arf1 Sptbn5 Sptbn4 Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Rab1b Gosr1 Gosr2 Dync1h1 Copz2 Copz1 Arf5 Golga2 Uso1 Actr10 Dync1i2 Dync1i1 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Cd59 Arcn1 Bet1 Dync1li2 Dync1li1 Dynll1 Dynll2 Ins1 Cd55 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 96%10222611 Regulation of clotting cascade F10 Procr F12 Gpc1 F11 Gpc3 Gpc2 Gpc5 Gpc4 Thbd Smpd1 Gpc6 Proc Klkb1 Pros1 Serpinc1 Sdc1 Serpine2 Serping1 Tfpi Proz Serpina10 Cd177 Pf4 Agrn Gp5 F2r Gp9 Gp1bb Serpine1 Gp1ba Ano6 Ano5 Kng1 F3 F7 F9 App Serpina5 Sdc4 Sdc3 Sdc2 F2 F8 Prtn3 Serpind1 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-RNO-9027284.1 Erythropoietin activates RAS Grb2 Irs2 Jak2 Vav1 Epor Shc1 Lyn Crkl Rapgef1 Epo DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 96%10224851 DNA Damage Recognition in GG-NER Ino80 Xpc Ddb2 Uba52 Cops4 Ino80e Cops2 Ino80d Ino80c Ino80b Cops7a Cops7b Mcrs1 Actg1 Ubb Ubc Ruvbl1 Parp2 Rad23a Parp1 Rad23b Nfrkb Rbx1 Cops3 Cops6 Tfpt Cops8 Actl6a Gps1 Rps27a Actr5 Yy1 Actr8 Cops5 Ddb1 Cul4a Cetn2 Cul4b FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 96%10222417 Formation of Incision Complex in GG-NER Chd1l Sumo3 Xpc Ddb2 Ube2n Gtf2h2 Ube2i Gtf2h1 Uba52 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Ercc1 Ercc4 Usp45 Ube2v2 Mnat1 Rpa1 Rpa2 Ubb Rpa3 Ubc Rnf111 Parp2 Rad23a Parp1 Rad23b Sumo2 Rbx1 Ccnh Rps27a Pias3 Pias1 Xpa Ddb1 Sumo1 Cul4a Cetn2 Cul4b MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222847 MAP kinase activation Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Mapk8 Traf6 Ikbkg Map3k8 Map3k7 Ube2n Uba52 Nfkb1 Fbxw11 Fos Btrc Vrk3 Rps6ka3 Rps6ka1 Rps6ka2 Tnip2 Nod2 Nod1 Map2k7 Map2k6 Ubb Dusp3 Ubc Dusp4 Ripk2 Dusp7 Dusp6 Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Cul1 Map2k3 Mapk1 Tab3 Tab2 Tab1 Chuk Mapk10 Mapk11 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 96%10224567 Regulation of necroptotic cell death Peli1 Uba52 Traf2 Birc2 Xiap Ubb Sdcbp Ogt Ubc Casp8 Mlkl Flot2 Flot1 Ripk3 Tradd Cflar Prkn Hsp90aa1 Stub1 Itch Ripk1 Rps27a Tnfsf10 Pdcd6ip Fas Cdc37 Fadd Faslg Ube2l3 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-RNO-1307965.1 betaKlotho-mediated ligand binding Klb Fgf19 Fgfr4 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-RNO-163685.1 Integration of energy metabolism Adcy5 Kcnb1 Adcy6 Kcns3 Kcnc2 Kcng2 Prkaca Prkacb Gnai2 Gnai1 Prkca Prkab2 Cacna1c Gna11 Cacna1d Adipoq Prkar1a Gna14 Adipor2 Prkar1b Adipor1 Mlxipl Marcks Gng3 Gng5 Gng4 Gnaq Gng7 Cacnb3 Gng8 Cacna1e Gngt1 Cacnb2 Itpr3 Cacna1a Prkar2a Itpr2 Slc2a2 Prkar2b Itpr1 Cacna2d2 Ffar1 Gnb2 Abcc8 Gnb1 Kcnj11 Gnb4 Gnb3 Gnb5 Gng11 Rap1a Gnas Acsl3 Acsl4 Cd36 Adra2a Adra2c Gcgr Rapgef4 Rapgef3 Prkaa2 Slc2a1 Gcg Plcb3 Glp1r Plcb2 Taldo1 Plcb1 Prkag2 Gng10-ps1 Tkt SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 96%10224521 SUMOylation of transcription cofactors Phc1 Sumo3 Cbx4 Zfp131 Pias4 Cbx2 Ube2i Phc3 Daxx Safb Ing2 Sin3a Trim28 Pcgf2 Bmi1 Mbd1 Park7 Mrtfa Npm1 Sumo2 Ep300 Nrip1 Rnf2 Ctbp1 Pias3 Ddx17 Pias1 Ring1 Pias2 Casp8ap2 Phc2 Uhrf2 Sumo1 ACTIVATION OF TRKA RECEPTORS%REACTOME%R-RNO-187015.1 Activation of TRKA receptors Ntrk1 Ngf SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224313 Synthesis of PIPs at the Golgi membrane Fig4 Vac14 Pi4k2a Pik3r4 Inpp5e Arf3 Arf1 Ocrl Sacm1l Pi4ka Pi4kb Pi4k2b Pik3c2g Tpte2 Pikfyve Pik3c2a Pik3c3 CD28 CO-STIMULATION%REACTOME%R-RNO-389356.1 CD28 co-stimulation Ppp2r5b Pik3r5 Ppp2r5a Pik3cg Map3k8 Ppp2cb Ppp2ca Pdpk1 Cd28 Ppp2r5e Rictor Cd86 Cd80 Prr5 Map3k14 Trib3 Ppp2r5d Lck Mapkap1 Grap2 Them4 Pik3ca Pak1 Rac1 Pak3 Ppp2r1b Ppp2r1a Mtor Pak2 Akt3 Akt2 Lyn Akt1 Yes1 Src Pik3r1 Pik3cb Grb2 Pik3r2 Fyn Pik3r3 Vav1 Pik3cd Pik3r6 Cdc42 Ctla4 Mlst8 CELLULAR HEXOSE TRANSPORT%REACTOME%R-RNO-189200.1 Cellular hexose transport Slc5a10 Slc2a2 Slc2a4 Slc2a1 Slc2a8 Slc2a3 Slc2a7 Slc2a9 Slc2a12 Slc50a1 Slc2a10 Slc45a3 Fgf21 Slc5a1 Slc5a2 Slc5a4 Mfsd4b4 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 96%10224065 Reactions specific to the complex N-glycan synthesis pathway Chst10 Fut8 Fuca1 Man2a1 Man2a2 Mgat2 PRPP BIOSYNTHESIS%REACTOME%R-RNO-73843.1 PRPP biosynthesis Prps1l3 Prps1 Prps2 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223763 Bicarbonate transporters Slc4a1 Slc4a10 Ahcyl2 Slc4a2 Slc4a4 Slc4a3 Slc4a5 Slc4a8 Slc4a7 Slc4a9 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224171 ATP sensitive Potassium channels Abcc9 Kcnj8 Abcc8 Kcnj11 COMPLEX I BIOGENESIS%REACTOME%R-RNO-6799198.1 Complex I biogenesis Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Ndufa5 Tmem186 Ndufaf3 Ndufaf2 Ndufaf1 Tmem126b Nubpl Acad9 Ndufv2 Ndufv1 Ndufv3 Ndufc2 Ndufa12 Ndufa11 Ndufa10 Ndufs1 Ecsit Ndufab1 Timmdc1 Ndufa13 Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Ndufa6 Hscb Ndufa9 Ndufb8 Ndufs3 Ndufa8 Ndufb11 Ndufb10 Ndufb1 Ndufb3 Rnf113a1 Ndufb5 Lyrm2 Ndufb7 Dmac2 Dmac1 Ndufa3-ps3 Hspa9 Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 FRUCTOSE CATABOLISM%REACTOME%R-RNO-70350.1 Fructose catabolism Tkfc Aldh1a1 Glyctk Aldob Khk ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-RNO-399997.1 Acetylcholine regulates insulin secretion Plcb3 Gna11 Gna14 Plcb2 Plcb1 Marcks Gnaq Prkca SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 96%10222853 Signaling by Interleukins Creb1 Stx1a Mapk3 Crkl Rapgef1 Rps6ka5 Grb2 Fyn P4hb Sos1 Tyk2 Il1rl2 Nkiras1 Il1f10 Vamp2 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Il6st Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Brwd1 Tslp Gsdmd Nfkb1 Il7 Traf2 Il7r Fbxw11 Il36a Fos Vrk3 Il36rn Il36g Alpk1 Rela Il18rap Il18r1 Rps6ka3 Il18bp Peli2 Rps6ka1 Sdc1 Peli3 Tifa Irs1 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Tec Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Tbk1 Jun Mapkapk2 Irak2 Il6 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Il6r Map2k3 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Il1rapl1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Vamp7 Psmb1 Psmb3 Psmb2 Uba52 Cntf Btrc Cntfr Psma7 Ifnlr1 Clcf1 Ctf1 Il20rb Psmc5 Il20ra Psmc2 Il31ra Psmc1 Lif Psmc4 Il10 Psmc3 Il11 Il22ra2 Stxbp2 Osmr Il10rb Il10ra Il22 Il11ra1 Ubb Il20 Il24 Ubc Osm Il22ra1 Psmb6l1 Lifr Ifnl1 Psmd7 Casp1 Ifnl3 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Mapk1 Il12rb1 Crk Il12rb2 Ebi3 Stx4 Il12b Il27 Il23a Il12a Crlf1 Ppp2cb Il23r Ppp2ca Prkaca Il33 Ppp2r5d Il1rap Map3k3 Il1rn Irak4 Irak3 Tollip Il1a Ppp2r1b Il1b Ppp2r1a Il1r2 Il1r1 Lyn Yes1 Il34 Ptprz1 Il16 Txlna Csf1r Stx3 Il18 Cd4 Lck Jak2 Snap25 Ctsg Socs1 Il13ra2 Il4r Stat6 Il13 Hsp90b1 Socs5 Il4 Stat3 Stat1 Il15 Il15ra Il9 Il21 Ptk2b Stat5a Stat5b Il9r Inpp5d Canx Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Smarca4 Il2 Il3 Il5 Csf2rb Sqstm1 Csf1 Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Pik3r3 Vav1 Inppl1 Pik3cd Ptpn11 H2bc18 Sos2 Irs2 Syk Hck Il1rl1 Casp3 Myd88 Rbx1 Socs3 Cbl Ywhaz GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-RNO-8856688.1 Golgi-to-ER retrograde transport Actr1a Dctn1 Dctn2 Rab1A Dctn4 Arfgap3 Arfgap2 Rab18 Arfgap1 Napa Nsf Napb Galnt1 Galnt2 Napg Kif3a Kdelr2 Kdelr3 Copa Kdelr1 Arf4 Arf3 Arf1 Copb2 Tmed10 Tmed9 Copb1 Cope Copz2 Copz1 Arf5 Actr10 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Tmed7 Arcn1 Kif4b Kif4a Racgap1 Bnip1 Kif18b Kif19 Kif26b Kifc1 Kifc2 Kif26a Kif11 Kif12 Kif15 Nbas Kif5a Kif5b Kif21a Kif1c Kif21b Kif13b Kif1a Kif1b Kif6 Kif9 Pafah1b1 Zw10 Rab3gap2 Rab3gap1 Kif22 Rab1b Kif23 Kif28 Rint1 Kif27 Kif16b Bicd2 Kif18a Kif20a Bicd1 Klc1 Agpat3 Dync1h1 Kif20b Pafah1b3 Kifap3 Pafah1b2 Klc4 Klc3 Klc2 Dync1i2 Dync1i1 Kif3b Kif3c Stx18 Pla2g6 Cenpe Kif2a Kif2b Use1 Kif2c Dync1li2 Dync1li1 Dynll1 Pla2g4a Dynll2 Rab6b Rab6a UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-RNO-5689880.1 Ub-specific processing proteases Keap1 Wdr48 Ddb2 Ufd1 Foxo4 Ifih1 Fkbp8 Il33 Wdr20 Adrb2 Atxn7 Suds3 Tnks2 Usp2 Mul1 Rce1 Usp3 ENSRNOG00000067432 Usp4 Axin1 Axin2 Usp5 Usp7 Usp8 Hgs Ruvbl1 Tomm20 Tada2b Smad1 Smad2 Smad3 Smad4 Smad7 Ide Otub1 Usp44 Usp42 Usp48 Ripk1 Rnf146 Usp47 Stam2 Usp30 Tnks Usp33 Usp37 H2ac25 Usp34 Usp9x Usp22 Usp21 Smurf2 Usp20 Traf6 Usp26 Usp25 Ikbkg Usp24 Usp29 Map3k7 Usp28 Ccp110 Arrb2 Arrb1 Pten Traf2 Usp12 Tgfbr1 Usp11 Usp10 Usp16 Usp15 Usp13 Usp19 Tp53 Clspn Kat2a Polb Rig1 Nfkbia H2ac4 Cyld Usp14 Gata3 Usp18 Tab1 Birc2 H2ac18 Taf9b Taf10 Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Cdc25a Psmd13 Skp2 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Tada3 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Myc Psmd2 Psmd1 Vdac2 Adrm1 Vdac3 Vdac1 Becn1 Tomm70 Mdm4 Rnf123 Rnf128 Snx3 Ar Hif1a Cftr Siah2 Mat2b HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10224645 Hedgehog ligand biogenesis Os9 Sel1l Disp2 Scube2 Hhat Psma4 Psma3 Notum Syvn1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 P4hb Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Gpc5 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Ihh Psmd2 Derl2 Psmd1 Shh Adrm1 Vcp Dhh Erlec1 DEPYRIMIDINATION%REACTOME%R-RNO-73928.1 Depyrimidination Neil1 Mbd4 Smug1 Ogg1 Nthl1 Tdg Ung Neil2 GENE SILENCING BY RNA%REACTOME%R-RNO-211000.1 Gene Silencing by RNA Polr2j Hist1h2ai Prkra H2ac18 Ago4 Ago3 Ago2 Ago1 Dicer1 Tarbp2 Hist1h2bq Ipo8 H2aj Tsnax H2ab2 Tnrc6c H3-3b Hist3h2ba Tnrc6a H2ac4 Tnrc6b ENSRNOG00000068602 Polr2c Polr2a Polr2b H2bc18 Polr2g Polr2h Tsn ENSRNOG00000066901 H2az2 Polr2e Ran Polr2f H2bc4 Hist1h4m Polr2i H2bc1 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-RNO-110329.1 Cleavage of the damaged pyrimidine Neil1 Mbd4 Smug1 Ogg1 Nthl1 Tdg Ung Neil2 CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 96%10224479 Ca2+ pathway Lef1 Map3k7 Ctnnb1 Pde6a Pde6b Wnt5a Gnat2 Calm3 Gng3 Ppp3ca Ppp3cb Nfatc1 Gng5 Gng4 Ppp3r1 Wnt11 Gng7 Gnao1 Nlk Gng8 Gngt1 Fzd3 Tcf7l2 Fzd2 Fzd5 Fzd4 Fzd6 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Kras Gng10-ps1 Pde6g Camk2a MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-RNO-947581.1 Molybdenum cofactor biosynthesis Nfs1 Gphn Mocos Mocs3 Mocs1 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 96%10222039 Aerobic respiration and respiratory electron transport Pdp1 Cox5a Pdpr Cox5b Pdp2 Pkml1 Ranbp9 Sirt3 Cox4i1 Cox4i2 Suclg1 Suclg2 Isca2 Pm20d1 Isca1 Trap1 Sdhaf1 Sdhaf2 Sdhaf3 Cs Slc25a27 Nnt Slc25a14 Ucp1 Ucp2 Ucp3 Fh Sdhd Sdhc Sdhb Sdha Aco2 Idh3B Idh3g Sucla2 Idh3a Fxn Ecsit Hscb Ndufb8 Ndufs3 Ldhal6b Glo1 Wdr26 Hagh Nek1 Mkln1 Fahd1 Gid4 Maea Ldha Ldhb Ldhc Armc8 Me1 Me3 Me2 Rmnd5b Cycsl2 Cox18 Tmem177 Cox20 Idh2 Cycs Mt-cyb Mt-atp6 Atp5mc1 Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Atp5pf Atp5mf Atp5me Pdhx Dmac2l Atp5mg Atp5f1b Atp5f1a Atp5po Atp5mk Mt-atp8 Ndufa5 Pdk4 Rps27a Pdk3 Pdk2 Pdk1 Pdhb Uba52 Ndufab1 Pdha1 Pdha2 Ubb Ubc Mt-co3 Dld Mt-co2 Vdac1 Mt-co1 Dlat Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 Gstz1 Nfs1 Higd1c Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Tmem186 Ndufaf3 Ndufaf2 Ndufaf1 Tmem126b Uqcrfs1 Nubpl Iscu Acad9 Etfdh Coq10a Coq10b Uqcrq Cyc1 Slc25a18 Ndufv2 Cox7a1 Slc25a22 Ndufv1 Cox7a2 Ndufv3 Uqcrb LOC120097699 Uqcrh Ndufc2 Ndufa12 Slc25a4 Ndufa11 Ndufa10 Ndufs1 Timmdc1 Ndufa13 Cox7a2l Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Ndufb1 Lyrm7 Ndufb3 Rnf113a1 Hccs AC132020.1 Uqcrc2 Ogdh Uqcrc1 Dlst Etfb Lyrm4 Kgd4 Ndufb5 Etfa Lyrm2 Ndufb7 Dmac2 Dmac1 Ndufa3-ps3 Uqcr10 Ttc19 Hspa9 Pgam5 Ndufa4 Got2 Cox6a1 Cox6a2 Cox6c2 Cox6b1 Cox6b2 Gpt Adhfe1 L2hgdh D2hgdh Got1 Mdh1 Cox8a Mdh2 Slc25a11 Cox8c Slc25a12 Slc25a13 Cox7b Pc Cox7c Acat1 Pklr CRMPS IN SEMA3A SIGNALING%REACTOME%R-RNO-399956.1 CRMPs in Sema3A signaling Gsk3b Crmp1 Plxna4 Plxna3 Plxna2 Cdk5 Dpysl3 Dpysl2 Dpysl4 Dpysl5 Sema3a Fes Fyn Nrp1 Plxna1 Cdk5r1 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-RNO-2871796.1 FCERI mediated MAPK activation ENSRNOG00000070986 Plcg1 Shc1 Rac1 Pak1 Pak2 Mapk3 Lyn Nras Vav3 Grb2 Vav1 Kras Vav2 Sos1 Hras Mapk9 ENSRNOG00000069193 AABR07065813.1 Lcp2 ENSRNOG00000062915 Igll1 Mapk8 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Syk Iglc1 Fos ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 Map3k1 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Map2k7 Plcg2 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 Grap2 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 Jun ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Mapk1 Lat Mapk10 NEUTROPHIL DEGRANULATION%REACTOME%R-RNO-6798695.1 Neutrophil degranulation Slco4c1 Ddost Magt1 Ppie Cfp Acaa1b Fuca1 Slc27a2 Sptan1 Nras Sting1 Rap1a Rap1b Tnfrsf1b Slc15a4 Iqgap2 Mmtag2 Nbeal2 Prdx4 Plac8 Cat Pgrmc1 Commd9 Golga7 Retn Lgals3 Ptprn2 Bin2 Nfkb1 Pa2g4 Cd36 S100a11 S100a9 Dynlt1 Gmfg Syngr1 Vapa Clec4a3 Clec4a2 Glipr1 Man2b1 Tmc6 Clec4b2 Grn Ceacam6 Ptges2 Enpp4 Cgm4 Ypel5 Nfam1 Clec6a-ps1 Aga Commd3 Pigr Pygb Kpnb1 Hmgb1-ps34 Crispld2 Ormdl3 Lamtor3 Dnajc13 Lamtor2 Lilrc2 Armc8 Rab44 Adgrg3 Vcl Ear1l1 Chrnb4 Epx Kcmf1 Mapk14 Tom1 Serpinb1a Rab37 Serpinb12 Ist1 Serpinb10 Psgb1 Hmgb1l2 Pkp1 Hmgb1l1 Dsc1 Bri3 Gpr84 Ptprb Ghdc Lamp1 Cep290 Arl8a Rab3d Ap2a2 Nit2 Chi3l1 Mospd2 Acp3 Tubb5 Slc2a5 Alad Itgav Crisp2 Olfm4 Atad3a Fgl2 Chit1 Dnase1l1 Hgsnat Mnda Frmpd3 Tubb4b Rnase17 Agpat2 Fcgr3a Mcemp1 Scamp1 Tmem179b Cant1 Unc13d Cpne1 Cpne3 Tmem30a Rnase2 Rnase3 Vat1 Tspan14 Cdk13 Prg3 Anpep Prg2 Fcn2 Bst2 Fcn1 Rap2b Rap2c Manba Cr1l Cap1 Mlec Snap29 Atp6v0a1 Cd53 Stk11ip Svip Atp6v0c ENSRNOG00000064486 Qpct ENSRNOG00000064129 Irag2 Cstb Gca Erp44 Elane Creg1 Hp Tcirg1 Cd68 Dok3 Hebp2 Cd93 ENSRNOG00000067708 Cotl1 Dpp7 Tarm1 Degs1 Ggh Cnn2 Atp6v1d Rab31 Nme2 Psg29 Dnajc5 Ddx3x Cracr2a Clec4a Clec4d Cpped1 Mvp Ms4a3 Pdap1 Kcnab2 Fth1-ps5 Oscar Tmem63a Cmtm6 Tnfaip6 Vps35l Ostf1 Ap1m1 Ptx3 Vamp8 Pafah1b2 Fth1 Slc44a2 Txndc5 Hspa8 Rab3a Ftl1 Itgax Gdi2 Rab7a Cfd A1bg Rab27a Cab39 Olr1 Tbc1d10c Lamtor1 Trappc1 Rab6a Ceacam1 Rab5c Ahsg Rab5b Serpina3n Serpinb6a Rab9b Rab10 Igf2r Rab14 Rab18 RT1-M6-2 Mgst1 Anxa2 Qsox1 B2m Gsn Gstp1 Atg7 Sh3glb2 Lamp2 RT1-M10-ps1 Pnp RT1-M10-ps5 Snap23 Cd177 Ampd3 RT1-N3 Aprt Rhoa Lrrc7 Itgal Eef2 Apeh Itgb2 RT1-M1-2 RT1-M1-5 Rt1-ec3 Arsa Mpo Huwe1 Asah1 P2rx1 Gm2a Mif Gla Arsb Xrcc6 Orm1 Rhog Xrcc5 Ano6 RT1-M5 Rab4b Atp6ap2 Ctsd Cd47 Ubr4 Mme RT1-M2 Ctsg Cd63 Cand1 Ctsz Prtn3 Ppia Padi2 Fcer1g Sell Cyba Cybb Sirpa Plau Pecam1 Npc2 Ptpn6 Plaur Fuca2 Trpm2 Dync1h1 Alox5 Lta4h AABR07044308.1 Lpcat1 Cst3 Atp11b Atp11a Gpi Arg1 Atp8b4 Dync1li1 Aoc1 Dynll1 Pgam1 Ticam2 Cd14 Aldoc Aldoa Pfkl Hmox2 Pkml1 Hk3 Hpse Hspa1b Hspa1a Nckap1l Ptprc Ttr Gsdmd S100a8 Tlr2 Ctsb Arhgap45 Ctss Arpc5 Dgat1 Jup Dsp Dsg1 Stom C3ar1 Impdh2 Pycard Arhgap9 Impdh1 Pld1 Hsp90ab1 Stk10 Faf2 Actr2 Mmp25 Ppbp Fpr1 Diaph1 Gns Adam10 Fpr2 C3 Galns Hexb Cyfip1 Krt1 Prcp Rhof Stbd1 Dock2 Adam8 Mmp8 Try10 Prss2l1 Tyrobp Try5 Cd44 LOC102554637 Sdcbp Rock1 Capn1 Timp2 Prss2 Acly Prss3 Rac1 Prss1 Psma5 Psma2 Hsp90aa1 Psmd12 Eef1a1 Psmd11 Psmd14 Psmd13 Psmb7 Dnajc3 Pdxk Psmb1 Ilf2 Psmc2 Srp14 Bst1 Psmc3 Vnn1 Ptafr Naprt Psmd7 Psmd6 Mmp9 Psmd2 Psmd1 Slc2a3 Mapk1 Fabp5 Cyb5r3 Dera Pgm2 Cd55 Clec5a Cxcr1 Apaf1 Cxcr2 Folr2 Prkcd Gusb Cda Tollip C5ar1 Nfasc Ctsc Np4 Defa24 Ear1 Copb1 Defal1 Pglyrp1 Defa31 Bpi Defa Camp Serpina1 Ltf Lyz1 Ndufc2 Actr10 Ctsh Hbb Slc11a1 Aldh3b1 Defa9 Defa8 Defa6 Cd59 Defa3 Lcn2 Ckap4 Idh1 Snap25 Psap Actr1b Siglec5 Siglec8 Adgre5 Cct2 Cxcl1 Lair1 Cct8 Csnk2b Gaa Agl Pygl Gyg1 Pgm1 Psen1 Ncstn Neu1 Fcgr2 Fgr Frk Prdx6 Glb1 Ctsa Vcp Hvcn1 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-RNO-5685939.1 HDR through MMEJ (alt-NHEJ) Fen1 Parp2 Mre11 Parp1 Rbbp8 Brca2 Rad50 Rad52 Nbn Polq Xrcc1 Lig3 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 96%10223573 Tachykinin receptors bind tachykinins Tacr1 Tacr3 Tac3 Tacr2 Tac1 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME DATABASE ID RELEASE 96%10222361 Transport of Mature mRNAs Derived from Intronless Transcripts Nup133 Cpsf1 Nup210 Ncbp2 Cpsf2 Nup155 Ncbp1 Cpsf3 Nup153 Nup93 Nup50 Alyref Nxf1 Slbp Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Fip1l1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Sympk Aaas Eif4e Ranbp2 Cpsf4 Nup214 ADIPOGENESIS%REACTOME DATABASE ID RELEASE 96%10223599 Adipogenesis Pparg Ncor2 Hdac3 Rxra PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-RNO-77595.1 Processing of Intronless Pre-mRNAs Cpsf7 Cpsf1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Pcf11 Fip1l1 Cstf1 Papola Nudt21 Cstf2 Cstf3 Cstf2t Sympk Pabpn1 Clp1 Cpsf4 Cpsf6 VITAMINS%REACTOME DATABASE ID RELEASE 96%10223395 Vitamins Cyp26b1 Cyp26a1 Cyp24a1 Cyp26c1 Cyp27b1 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME%R-RNO-192105.1 Synthesis of bile acids and bile salts Osbpl6 Cyp39a1 Osbpl9 Hsd3b7 Ncoa2 Akr1d1 Amacr Baat Cyp8b1 Akr1c18 Cyp7b1 Akr1c12l1 Akr1c19 Nr1h4 Akr1c21 Cyp46a1 Scp2 Cyp27a1 Osbp Slc27a5 Cyp7a1 Acox2 Abcb11 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Hsd17b4 Akr1c9 Slc27a2 Ch25h Osbpl3 Osbpl2 Acot8 Osbpl1a Osbpl7 Rxra MELANIN BIOSYNTHESIS%REACTOME%R-RNO-5662702.1 Melanin biosynthesis Slc45a2 Dct Tyr Oca2 Tyrp1 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225141 Interleukin-9 signaling Jak3 Stat3 Stat1 Il9 Stat5a Stat5b Il9r BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-RNO-9018683.1 Biosynthesis of DPA-derived SPMs Alox12 Ptgs2 Alox5 Alox15 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174411.1 Polymerase switching on the C-strand of the telomere Terf2 Acd Terf1 Rfc5 Terf2ip Pold2 Tinf2 Pold1 Rfc3 Pot1 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Chtf8 Chtf18 Ctc1 Stn1 Ten1 Dscc1 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225347 RND3 GTPase cycle Wdr6 Txnl1 Epha2 Dlg5 Ccdc88a Ubxn11 Arhgap35 Cpd Ankrd26 Picalm Dst Tmod3 Dsp Arhgap5 Ktn1 Plekhg5 Dsg1 Nisch Ckap4 Ckb Rock1 Scrib Ddx4 Fam83b Rnd3 Cav1 Flot2 Kctd13 Pik3r1 Pik3r2 Sema4f Rbmx Depdc1b Ptpn13 Vangl2 Muc13 Arhgap21 Tnfaip1 Rasal2 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%10223923 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Xrn1 Zfp36l1 Mapkapk2 Dis3 Akt1 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Exosc6 Exosc1 Dcp2 Exosc3 Exosc2 Ywhab Dcp1a REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%10222543 Regulated Necrosis Birc2 Bax Bak1 Gzmb Xiap Sdcbp Elane Il1a Il1b Mlkl Flot2 Flot1 Ripk3 Tradd Cflar Prkn Hsp90aa1 Stub1 Itch Ripk1 Rps27a Tnfsf10 Pdcd6ip Fas Cdc37 Fadd Faslg Ube2l3 Chmp2a Peli1 Uba52 Gsdme Gsdmd Traf2 Il18 Casp3 Ubb Ogt Hmgb1-ps34 Ubc Casp1 Casp8 Chmp2b Cycsl2 Chmp3 Hmgb1l2 Chmp7 Hmgb1l1 Chmp6 Chmp4c Chmp4bl1 Cycs PROLONGED ERK ACTIVATION EVENTS%REACTOME%R-RNO-169893.1 Prolonged ERK activation events Braf Frs2 Ntrk1 Ngf Mapk3 Crkl Rapgef1 Map2k2 Map2k1 Mapk1 Rap1a Ywhab Crk Kidins220 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME%R-RNO-9006927.1 Signaling by Non-Receptor Tyrosine Kinases Erbb2 Ccnd1 Erbb3 Ereg Uba52 Stat3 Stap2 Nrg2 Gpnmb Lrrk2 Nrg3 Dok1 Btc Arhgap35 Rasa1 Egf Elmo1 Ubb Elmo2 Arap1 Ubc Pxn Cdkn1b Egfr Bcar1 Ptpn1 Rac1 Sfpq Khdrbs1 Khdrbs3 Hbegf Khdrbs2 Akt1 Cdk2 Socs3 Rhoa Cbl Nras Ccne1 Rps27a Kras Hras Cdk4 Srms Hif1a Crk Ptk6 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-RNO-1855196.1 IP3 and IP4 transport between cytosol and nucleus Nup133 Nup210 Nup155 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 96%10223265 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Siglec10 Klrk1 Jaml RT1-M6-2 B2m Itga4 RT1-M10-ps1 RT1-M10-ps5 RT1-N3 Itgal Itgb2 Cd40lg RT1-M1-2 Cd40 Cd22 RT1-M1-5 Rt1-ec3 Cd3g Cd247 Cd3e Cd3d Trav19 Trem1 AC109737.1 ENSRNOG00000065955 Trbv16 Nectin2 Pvr RT1-M5 Siglec1 Siglec5 Siglec8 LOC100910497 RT1-M2 Slamf6 Slamf7 Hcst C3 Kir3dl1 Pilrb2l4 Ifitm1 Ifitm2 Ifitm6 Pilrb1l3 Pilrb-ps7 Cd160 ENSRNOG00000070312 Pianp Cd226 Ifitm3-ps2 LOC134481331 Lair1 Treml2 Treml4 Cd200 Sell Cd1d ifitm3 Trem2 Cd34 Itgb1 Cd200r1l LOC120093164 Cd96 Cd81 Crtam Cd8b Cd8a Cd300le Cd300ld Cd300lg Cd300lf Klrb1a Clec4g Clec2e Cd19 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 AABR07044308.1 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Cxadr Igkvl13 AABR07065812.2 ENSRNOG00000063707 Madcam1 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 Itgb7 ENSRNOG00000064481 Icam1 ENSRNOG00000065690 Icam5 ENSRNOG00000064085 Icam4 ENSRNOG00000066904 Icam2 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 Vcam1 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%10224415 NOTCH3 Activation and Transmission of Signal to the Nucleus Aph1b Ybx1 Egfr Jag1 Uba52 Jag2 Notch3 Dll1 Dll4 Rps27a Egf Adam10 Wwp2 Psenen Psen1 Psen2 Ubb Ncstn Ubc Aph1a FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-RNO-9615017.1 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Atxn3 Foxo4 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 96%10223845 Zinc influx into cells by the SLC39 gene family Slc39a4 Slc39a3 Slc39a2 Slc39a1 Slc39a8 Slc39a7 Slc39a6 Slc39a14 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-RNO-1630316.1 Glycosaminoglycan metabolism Dsel Ust Dse Cspg5 Bgn Cspg4 Chst14 Chst15 Idua Hyal4 Hyal3 Naglu Ids Hyal1 Hpse2 Hpse Gusb Sgsh Slc9a1 Abcc5 Sdc4 Sdc3 Sdc2 Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Slc26a2 Slc26a1 Gpc6 Slc35b3 Slc35b2 Papss2 Papss1 Slc26a11 Sdc1 Arsb Slc35d2 Glb1l B3gnt7 B3gnt2 Kera Gns B4galt4 B4galt5 B4galt6 Prelp Glb1l3 Glb1l2 Fmod Galns Uxs1 Hexa Hexb B4gat1 Lum Omd Chst1 Chst3 Chst2 B4galt2 B4galt3 Acan Chst6 Hyal5 Ogn Ctsl Cd44 Chp1 Slc17a5 B3galt6 Cemip Fam20b St3gal6 B4galt7 Pxylp1 St3gal4 Chp1l1 Hyal2 St3gal2 Has1 St3gal3 Has2 Has3 St3gal1 Xylt1 Hs3st4 Xylt2 Hs3st1 Glb1 Hs3st2 Extl2 Hs3st5 Hs3st6 Hs3st3b1 Bcan Hs2st1 Ndst1 Vcan Ndst2 Ndst3 Ndst4 Agrn Hs3st3a1 Hs6st3 Ncan Hs6st2 Dcn Hs6st1 Ext2 Ext1 Chst11 Chst12 Chsy1 Chsy3 Chst13 Chpf Csgalnact2 Chst7 Chst9 B3gnt3 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-RNO-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) Xab2 Cdk7 Ppie Ercc1 Ercc4 Tcea1 Mnat1 Polk Prpf19 Usp7 Cops3 Cops6 Cops8 Isy1 Rps27a Gps1 Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Ercc6 Polr2i Polr2j Gtf2h2 Uba52 Gtf2h1 Gtf2h3 Gtf2h5 Cops4 Ercc2 Ercc3 Cops2 Lig3 Pole3 Pole2 Cops7a Pole4 Cops7b Znf830 Rpa1 Rpa2 Aqr Uvssa Ubb Rpa3 Ubc Lig1 Pole Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Xrcc1 Rfc2 Ccnh Pold4 Pold3 Cops5 Xpa Ddb1 Cul4a Cul4b TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 96%10223367 Transport to the Golgi and subsequent modification Lman1 Scfd1 Actr1a Lman2 Ins2 Sec22a Dctn1 Tfg Dctn2 Cog1 Cog2 Rab1A Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Cog6 Cog7 Cog8 Napa Nsf Napb Ank1 Napg Sec23a Fut8 Tmem115 Fuca1 Kdelr2 Man2a1 Kdelr3 Man2a2 Mgat2 Sec23ip Sec16b Sec16a Spta1 Lman2l Copa Bet1l Cnih1 Gorasp1 Cnih3 Sptb Cnih2 Sptbn1 Sptbn2 Kdelr1 Arf4 Ctsc Arf3 Sptan1 Sptbn5 Arf1 Ppp6r3 Mia2 Sptbn4 Mia3 Sar1b Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Col7a1 Tgfa Ppp6c Sec31b Gria1 Areg Sec31a F8 Stx17 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 B4galt4 B4galt5 B4galt6 Ctsz B4galt2 B4galt3 Chst10 Rab1b Trappc2l Dync1h1 St8sia6 Trappc10 Dync1i2 Dync1i1 St3gal4 St6gal1 Mgat5 Mgat1 Mgat3 Mgat4a St8sia2 Manea St8sia3 Man1c1 Man1a2 Man1a1 Mgat4c Mgat4b Sec13 Trappc6b Dync1li2 Trappc6a Trappc9 Dync1li1 Trappc5 Dynll1 Trappc4 Dynll2 Trappc3 Trappc2 Trappc1 Ins1 Cd55 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 96%10223821 Transport of glycerol from adipocytes to the liver by Aquaporins Aqp9 Aqp7 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 96%10222573 GPVI-mediated activation cascade Pik3r5 Pik3cg Pdpk1 Fcer1g Mpig6b Pdpn Syk Lck Plcg2 Pik3ca Gp6 Rhog Rac1 Ptpn6 Rhob Rac2 Lyn Pik3r1 Rhoa Pik3cb Vav3 Pik3r2 Fyn Pik3r3 Vav1 Vav2 Ptpn11 Pik3r6 Lat Cdc42 Lcp2 Clec1b REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME%R-RNO-1234158.1 Regulation of gene expression by Hypoxia-inducible Factor Cited2 Epas1 Hif3a Crebbp Hif1a Ep300 Arnt CIPROFLOXACIN ADME%REACTOME%R-RNO-9793528.1 Ciprofloxacin ADME Slc22a1 Abcg2 Alb Slco1a4 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 96%10224439 Electron transport from NADPH to Ferredoxin Fdx2 Fdxr Fdx1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 96%10224319 SRP-dependent cotranslational protein targeting to membrane LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Srp68 Srp9 Srp54 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Srp14 Rpl36al1 Rpl39l1 Srp19 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 PI METABOLISM%REACTOME%R-RNO-1483255.1 PI Metabolism Inpp5e Rab14 Ocrl Inpp5j Sacm1l Pi4ka Synj1 Pi4kb Pik3c2g Tpte2 Inpp5d Pik3ca Mtmr1 Pip5k1c Arf3 Arf1 Pik3r1 Sbf1 Pik3cb Pik3r2 Synj2 Pik3r3 Inppl1 Pik3cd Ptpn13 Inpp5f Pi4k2b Inpp4a Pikfyve Inpp4b Pik3c2a Pik3c3 Plekha8 Mtm1 Pik3r5 Fig4 Pik3cg Vac14 Mtmr12 Pi4k2a Pip4k2b Mtmr4 Pip4k2c Pik3r4 Pip4k2a Rab5a Pten Rab4a Pip5k1b Pip5k1a Mtmr14 Plekha6 Plekha5 Plekha4 Pip4p1 Plekha3 Plekha2 Plekha1 Mtmr3 Tnfaip8l2 Tnfaip8l3 Tnfaip8l1 Rufy1 Pitpnb Inpp5k Pik3c2b Bmx Tnfaip8 Mtmr7 Mtmr6 Mtmr9 Pik3r6 Gde1 Pnpla6 Enpp6 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 96%10222693 Porphyrin metabolism Gsta5 Slco2b1 Fabp1 Blvrb Hmox2 Blvra Abcg2 Abcc1 Hmox1 Abcc2 Ugt1a2 Ugt1a1 Ugt1a3 Ugt1a5 Alb Uros Alas1 Alas2 Hmbs Cpox Fech Alad Ppox Cox10 Cox15 Slco1b2 Urod TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 96%10222785 Toll Like Receptor 4 (TLR4) Cascade Cd180 Ly86 Ptpn4 Ppp2cb Ppp2ca Ube2d3 Ppp2r5d Ube2d2 Creb1 Ppp2r1b Ppp2r1a Mapk3 Ripk3 Rps6ka5 Ripk1 Fadd Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Bpi Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Lbp Fos Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Dnm2 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Tbk1 Jun Irf3 Mapkapk2 Irak2 Irak1 Ager Nfkbia Ikbke Hmgb1l2 Hmgb1l1 Nlrx1 Tirap Map2k3 Usp14 Tab3 Tab2 Dnm3 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Birc2 Optn Rps27a Ptpn11 Skp1 Uba52 Ube2d1 Btrc Plcg2 Ubb Ubc Dnm1 Cul1 Mapk1 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 96%10223569 Clearance of dopamine Maoa Tomt Slc6a3 Comt INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223091 Intestinal absorption Npc1l1 Slc2a2 Slc5a1 Slc2a5 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 96%10223081 Digestion of dietary carbohydrate Si Amy2 Lct Chia Chit1 KEAP1-NFE2L2 PATHWAY%REACTOME DATABASE ID RELEASE 96%10224743 KEAP1-NFE2L2 pathway Keap1 Ufd1 Gsk3b Map1lc3b Crebbp Mul1 Srxn1 Prdx1 Nfe2l2 Prkci Sesn2 Psma4 Sesn1 Psma3 Akt3 Akt2 Sqstm1 Akt1 Psma6 Ep300 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Nploc4 Psmd14 Psmd13 Bach1 Skp1 Psmb5 Psmb4 Psmb7 Trim21 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Prkaa2 Psmd1 Ubxn7 Adrm1 Rbx1 Cul1 Vcp Cul3 NUCLEOSOME ASSEMBLY%REACTOME%R-RNO-774815.1 Nucleosome assembly Hist1h2ai Itgb3bp Rsf1 Oip5 Mis18a Rbbp4 Cenpc Rbbp7 Cenpw Cenpa H2ac18 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Hist1h2bq Cenpm Cenpl Cenpk Cenpi Cenph Ruvbl1 Npm1 H2aj H2ab2 Hist3h2ba H2ac4 ENSRNOG00000068602 Knl1 Mis18bp1 Hjurp ENSRNOG00000066901 H2az2 Smarca5 H2bc4 Hist1h4m H2bc1 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-RNO-75896.1 Plasmalogen biosynthesis Gnpat Dhrs7b Agps RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME%R-RNO-380320.1 Recruitment of NuMA to mitotic centrosomes Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Numa1 Dync1h1 Csnk1d Ccp110 Dync1i2 Nde1 Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Tubg2 Clasp1 Tubg1 Ywhae Cep63 Nme7 Cep152 Tuba4a Plk1 Tubgcp2 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Tubgcp6 Cdk1 Tubgcp5 Tubgcp4 Tubgcp3 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 Mzt1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223911 activated TAK1 mediates p38 MAPK activation Ikbkg Map3k7 Ube2n Mapkapk3 Mapk14 Mapkapk2 Irak2 Irak1 Map2k3 Tab3 Tab2 Tab1 Nod2 Nod1 Mapk11 Map2k6 Traf6 Ripk2 PHOSPHORYLATION OF THE APC C%REACTOME%R-RNO-176412.1 Phosphorylation of the APC C Ccnb1 Plk1 Anapc10 Ube2d1 Anapc16 Ube2s Cdc16 Anapc15 Cdk1 Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Anapc7 Ube2e1 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223363 COPII-mediated vesicle transport Lman1 Scfd1 Lman2 Sec22a Tfg Rab1A Preb Napa Nsf Napb Napg Sec23a Sec23ip Sec16b Sec16a Lman2l Cnih1 Gorasp1 Cnih3 Cnih2 Ctsc Ppp6r3 Sar1b Tmed10 Col7a1 Tgfa Ppp6c Sec31b Areg Sec31a Gria1 Rab1b F8 Stx17 Trappc2l Gosr2 Lman1l Tbc1d20 Csnk1d Serpina1 Golga2 Uso1 Sec24d Trappc10 Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Tmed2 Folr1 Ankrd28 Cd59 Bet1 Sec13 Trappc6b Trappc6a Trappc9 Trappc5 Trappc4 Trappc3 Trappc2 Trappc1 Ctsz DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-RNO-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling Psmb6 Psmb1 Psmb3 Psmb2 Relb Uba52 Nfkb2 Fbxw11 Btrc Psma7 Psmc5 Psmc2 Ube2m Psmc1 Uba3 Psmc4 Psmc3 Map3k14 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Chuk Skp1 Psmb5 Psmb4 Psmb7 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%10225059 MET promotes cell motility Hgf Megf11 Itga2 Rac1 Ptk2 Met Crkl Src Rapgef1 Tns4 Tns3 Grb2 Lama4 Rap1a Rap1b Itgb1 Dock7 Itga3 Crk Gab1 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 96%10222371 C6 deamination of adenosine Adarb1 Adar INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 96%10224951 Intra-Golgi and retrograde Golgi-to-ER traffic Rab43 Tmf1 Sys1 Actr1a Golga1 Vps51 Vps52 Dctn1 Vps54 Arl1 Rab9a Gcc2 Dctn2 Rab9b Gcc1 Cog1 Cog2 Usp6nl Rab1A Dctn4 Stx6 Cog3 Ttgn1 Ric1 Cog4 Igf2r Arfgap3 Scoc M6pr Arfgap2 Vti1a Cog5 Vamp3 Rab18 Arfgap1 Vamp4 Cog6 Stx16 Cog7 Rgp1 Arfip2 Cog8 Rhobtb3 Napa Rabepk Nsf Arfrp1 Napb Galnt1 Galnt2 Napg Kif3a Kdelr2 Kdelr3 Copa Bet1l Kdelr1 Arf4 Arf3 Arf1 Copb2 Tmed10 Tmed9 Copb1 Cope Gosr1 Gosr2 Copz2 Copz1 Arf5 Actr10 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Tmed7 Arcn1 Trip11 Kif4b Kif4a Alpi Cyth2 Cyth3 Cyth4 Cyth1 Racgap1 Bnip1 Kif18b Kif19 Kif26b Kifc1 Snap29 Kifc2 Kif26a Kif11 Kif12 Kif15 Nbas Kif5a Rab36 Kif5b Kif21a Kif1c Kif21b Kif13b Kif1a Kif1b Kif6 Kif9 Pafah1b1 Zw10 Rab3gap2 Rab3gap1 Kif22 Rab1b Kif23 Kif28 Rint1 Kif27 Kif16b Bicd2 Kif18a Kif20a Bicd1 Klc1 Agpat3 Dync1h1 Kif20b Pafah1b3 Kifap3 Pafah1b2 Klc4 Klc3 Klc2 Dync1i2 Rab33b Dync1i1 Kif3b Kif3c Vps45 Stx18 Pla2g6 Cenpe Rab39a Kif2a Kif2b Use1 Kif2c Akp3 Dync1li2 Alpp Alpg Dync1li1 Dynll1 Pla2g4a Dynll2 Rab6b Rab6a Golga4 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 96%10225023 PTK6 promotes HIF1A stabilization Egfr Gpnmb Lrrk2 Hbegf Hif1a Ptk6 FIBRONECTIN MATRIX FORMATION%REACTOME%R-RNO-1566977.1 Fibronectin matrix formation Itgb1 Fn1 Ceacam1 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-RNO-8874177.1 ATF6B (ATF6-beta) activates chaperones Mbtps1 Atf6b CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 96%10222703 Conjugation of carboxylic acids Glyatl3 Acsm2 Acsm4 Acsm5 Glyat PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 96%10225551 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Pelo Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps2 Rps27 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 LOC134480579 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rpl23a Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Hbs1l Rps6 LOC100910714 LYSINE CATABOLISM%REACTOME%R-RNO-71064.1 Lysine catabolism Aldh7a1 Phykpl Aadat Slc25a21 Gcdh Dld Dhtkd1 Pipox Crym Aass Hykk Dlst SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 96%10224399 Synthesis of 15-eicosatetraenoic acid derivatives Alox15b Gpx4 Ptgs2 Alox15 Gpx2 Gpx1 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 96%10222761 Transcription from mitochondrial promoters Polrmt Tfb2m Mterf1 Tfam EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%10222579 Effects of PIP2 hydrolysis Dgkq Prkch Prkce Dgkz Itpr3 Itpr2 Itpr1 Prkcq Prkcd Dgka Daglb Dgkb Abhd6 Trpc7 Dgkd Trpc3 Dgke Mgll Dgkg Abhd12 Dagla Dgkh Dgki Dgkk SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-RNO-9668328.1 Sealing of the nuclear envelope (NE) by ESCRT-III Tubb4b Tubb4a Tuba1a Tuba1c Tubal3 Chmp2b Tuba4a Cc2d1b Spast Tubb2b Tubb2a Ist1 Chmp3 Chmp7 Chmp6 Vps4a Tuba8 Chmp4c Tuba3b Chmp4bl1 Tubb6 Tubb3 Tubb1 Tuba1b Chmp2a EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 96%10223059 EGFR downregulation Spry1 Ereg Uba52 Ptpn12 Btc Ptpn3 Egf Eps15 Ubb Arhgef7 Ubc Hgs Eps15l1 Egfr Hbegf Spry2 Cbl Rps27a Stam2 Grb2 Epn1 Sh3gl3 Sh3kbp1 Tgfa Stam Cdc42 Sh3gl2 Areg Sh3gl1 N-GLYCAN ANTENNAE ELONGATION%REACTOME%R-RNO-975577.1 N-Glycan antennae elongation St8sia6 Mgat4c Mgat4b B4galt2 B4galt3 St3gal4 B4galt4 B4galt5 B4galt6 St6gal1 Mgat5 Mgat4a St8sia2 St8sia3 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 96%10221953 TP53 Regulates Transcription of Cell Cycle Genes Cnot3 Cnot2 Ccnb1 Cnot1 Cnot7 Cnot6 Cnot4 Cnot9 Cnot8 Aurka Bax Cnot6l Plk2 Btg2 E2f7 E2f8 Npm1 Cdkn1b Gadd45a Ccna1 Cnot11 Pcna Cdc25c Ccna2 Cnot10 Cdk2 Cdk1 Ccne1 Ccne2 Tnks1bp1 Cpap Sfn Plk3 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME DATABASE ID RELEASE 96%10224393 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) F11r Uba52 Cgn Tgfbr1 Tgfbr2 Pard6a Rhoa Smurf1 Rps27a Prkcz Ubb Pard3 Ubc Tgfb1 SIGNALING BY NTRKS%REACTOME%R-RNO-166520.1 Signaling by NTRKs Ppp2cb Ppp2ca Furin Pcsk5 Frs2 Ntrk1 Ngf Pcsk6 Plcg1 Ppp2r5d Creb1 Pik3ca Shc1 Rac1 Braf Ppp2r1b Ppp2r1a Mapk3 Crkl Pik3r1 Src Rapgef1 Rhoa Rps6ka5 Pik3cb Ntrk3 Nras Ntf3 Chd4 Pik3r2 Grb2 Fyn Rap1a Kras Dock3 Sos1 Hras Atf1 Mapk7 Irs2 Nab2 Dnal4 Egr2 Vrk3 Sgk1 Ntf4 Map2k2 Rps6ka3 Map2k1 Rps6ka1 Irs1 Bdnf Rps6ka2 Ntrk2 Dusp3 Ap2m1 Srf Dusp4 Clta Dusp7 Cltc Dusp6 Shc3 Shc2 Mapkapk3 Mapk14 Mapkapk2 Ap2s1 Mapk1 Ralgds Ap2a2 Ap2a1 Ap2b1 Sh3gl2 Mapk11 Ywhab Crk Kidins220 MET ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 96%10225075 MET activates STAT3 Hgf Stat3 Met NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10224537 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Wwox Tfap2c Tfap2a Ube2i Tfap2b Kctd1 Tfap2e Sumo1 BETA DEFENSINS%REACTOME%R-RNO-1461957.1 Beta defensins Tlr1 Defb14 Defb17 Defb18 Defb41 Ccr6 Defb42 Defb21 Tlr2 Defb5 Defb43 Defb44 Defb24 Defb1 Defb25 Defb28 Defb30 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225035 Regulation of RUNX1 Expression and Activity Cbfb Ccnd1 Ptpn11 Runx1 Cdk6 Ccnd2 Ccnd3 Pml TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 96%10222787 Toll-like Receptor Cascades Cd180 Ly86 Ptpn4 Ppp2cb Ppp2ca Tasl Eea1 Tlr10 Irf5 Ube2d3 Ppp2r5d Ube2d2 Creb1 Ppp2r1b Ppp2r1a Mapk3 Ripk3 Rps6ka5 Ripk1 Apob Fadd Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Slc15a4 Nkiras2 Mapk8 Traf6 Peli1 Bpi Ikbkg Map3k8 Map3k7 Ube2n S100a1 Gsdme Lrrc14 Nfkb2 Tlr1 Gsdmd Nfkb1 Traf2 Tlr7 Cd36 S100a9 Ecsit Tlr6 Fbxw11 Lbp S100a8 Fos Vrk3 Tlr2 Ctsb Alpk1 Rela Ctss Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Dnm2 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Tbk1 Jun Irf3 Mapkapk2 Irak2 Irak1 Ager Nfkbia Ikbke Hmgb1l2 Hmgb1l1 Nlrx1 Tirap Map2k3 Usp14 Tab3 Tab2 Dnm3 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Unc93b1 Lgmn Tlr8 Cnpy3 Fgb Hsp90b1 Fga Fgg Birc2 Ctsk Ctsl Rbsn Tlr9 Optn Rps27a Ptpn11 Skp1 Pik3c3 Uba52 Pik3r4 Ube2d1 Btrc Plcg2 Ubb Ubc Dnm1 Cul1 Mapk1 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%10222813 Initial triggering of complement Fcn2 Fcn1 Mbl2 Masp1 Masp2 C4b C1qb Crp C1qa C2 C4 Colec10 C1s C1r C1qc ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 C3 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 96%10224249 Synthesis of PE Chkb Selenoi Phospho1 Lpin3 Lpin2 Pcyt2 Cept1 Etnk2 Etnk1 Etnppl Chka PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%10224307 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling Erbb2 Ppp2cb Ins2 Erbb3 Ppp2ca Ereg Frs2 Btc Il33 Pdgfa Ppp2r5d Pdgfb Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Il1rap Irak4 Fgf17 Fgf18 Fgf19 Ppp2r1b Ppp2r1a Fgf10 Mapk3 Hbegf Src Ntrk3 Ntf3 Grb2 Fyn Tgfa Fgf20 Fgf23 Areg Fgf22 Kit Traf6 Ppp2r5b Ppp2r5a Pip5k1b Kitlg Ppp2r5e Klb Irs1 Fgf2 Fgf1 Fgf4 Lck Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Hgf Egfr Rhog Irak1 Rac2 Pdgfrb Pdgfra Kl Flt3 Esr1 Nrg2 Nrg3 Met Egf Pik3ca Insr Rac1 Gab2 Pip5k1c Akt1 Pik3r1 Pik3cb Cd19 Pik3r2 Pik3r3 Vav1 Pik3cd Ptpn11 Gab1 Pik3r5 Pik3cg Irs2 Ier3 Pip4k2b Pip4k2c Pip4k2a Pik3ap1 Cd28 Icos Ntf4 Pip5k1a Strn Cd86 Cd80 Esr2 Bdnf Il1rl1 Trat1 Myd88 Ntrk2 Mapk1 Pik3r6 Ins1 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224045 Negative regulation of FGFR4 signaling Ppp2cb Ppp2ca Uba52 Frs2 Klb Fgf2 Fgf1 Fgf4 Fgf6 Ubb Fgf8 Ubc Fgfr4 Fgf9 Fgf16 Fgf17 Fgf18 Fgf19 Braf Ppp2r1a Mapk3 Src Spry2 Mknk1 Cbl Mapk1 Rps27a Grb2 Ptpn11 Fgf20 Fgf23 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 96%10223761 Synthesis, secretion, and deacylation of Ghrelin Igf1 Bche Mboat4 Ins2 Spcs3 Ghrl Spcs1 Spcs2 Pla2g7 Pcsk1 Gcg Lep Sec11c Gh1 Sec11a Ins1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME DATABASE ID RELEASE 96%10223199 Axonal growth inhibition (RHOA activation) Ngfr Mag Mcf2 Omg Arhgdia Rhoa Rtn4 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 96%10224179 Classical Kir channels Kcnj4 Kcnj2 Kcnj14 Kcnj12 VEGFA-VEGFR2 PATHWAY%REACTOME%R-RNO-4420097.1 VEGFA-VEGFR2 Pathway Pdpk1 Prkaca Ctnnb1 Prkacb Plcg1 Prkcd Prkca Cyba Cybb Mapk12 Rasa1 Trib3 Calm3 Itgb3 Vegfa Kdr Elmo2 Ptk2b Nckap1l Rock2 Rock1 Them4 Pxn Pik3ca Nck2 Rac1 Pak1 Cav1 Pak3 Pak2 Akt3 Baiap2 Ptk2 Akt2 Akt1 Pik3r1 Src Rhoa Pik3cb Hsp90aa1 Nras Vav3 Pik3r2 Fyn Vav1 Kras Vav2 Mapk13 Hras Abi2 Abi1 Sphk1 Nck1 Ncf1 Ncf2 Ncf4 Rictor Ctnna1 Prkcz Brk1 Prr5 Jup Shb Ctnnd1 Sh2d2a Elmo1 Mapkap1 Axl Bcar1 Wasf3 Wasf2 Shc2 Mapkapk3 Wasf1 Mapk14 Prkcb Mapkapk2 Mtor Nos3 Hspb1 Cdc42 Mapk11 Nckap1 Itgav Mlst8 Crk Cyfip2 Cyfip1 METALLOPROTEASE DUBS%REACTOME%R-RNO-5689901.1 Metalloprotease DUBs Hist1h2ai Uba52 Abraxas2 H2ac18 Babam1 Babam2 Brca1 Bard1 Uimc1 Ubb Ubc Nlrp3 Stambp Stambpl1 Ep300 H2ac4 ENSRNOG00000068602 Rps27a Psmd14 H2ac25 Mysm1 Stam Kat2b Brcc3 ABRAXAS1 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10225535 Interaction of NuRD complexes with transcription factors Hist1h2ai Rbbp4 Rbbp7 H2ac18 Hist1h2bq Hdac1 Hdac2 H2aj Nr2c2 H2ab2 Zmynd8 Ikzf3 Ikzf1 Zfp827 H3-3b Zfp532 Hist3h2ba H2ac4 ENSRNOG00000068602 Phf6 Chd3 Zfp592 Chd4 Cdk2ap1 Mbd2 Nr2f2 Mta1 H2bc18 Chd5 Mta2 Mta3 Tcf19 ENSRNOG00000066901 Mbd3 H2az2 H2bc4 Hist1h4m H2bc1 Zfp687 Gatad2a Gatad2b GAB1 SIGNALOSOME%REACTOME%R-RNO-180292.1 GAB1 signalosome Pxn Egfr Pik3ca Ereg Hbegf Btc Pag1 Src Pik3r1 Csk Grb2 Egf Ptpn11 Tgfa Areg Gab1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 96%10222733 Post-translational modification: synthesis of GPI-anchored proteins Fcgr3a Alpi Folr2 Lypd6b Rtn4rl2 Gpld1 Lypd8 Tecta Lypd5 Lypd4 Pign Lypd3 Pigq Negr1 Pigp Tex101 Pigw Lypd2 Pigv Lypd1 Pigx Pigc Alpl Pigb Opcml Tectb Dpm2 Piga Dpm1 Pigm Dpm3 Pigl Otoa Pigg Izumo1r Pigf Ly6g6d Pigh Cd52 Prss21 Nrn1 Ntm Pigs Gp2 Pigu Xpnpep2 Pigt Thy1 Gpaa1 Pigk Art4 Plaur Meltf Art3 Atrnl1 Pgap1 Lsamp Reck Psg29 Sprn Plet1 Psca Spaca4 Cntn4 Mdga1 Cntn3 Mdga2 Cntn5 Ly6e Gpihbp1 Ly6h Prnd Ly6d Prss41 Bst1 Ceacam6 Vnn1 Cd109 Cgm4 Msln Akp3 Psgb1 Alpp Alpg Ceacam1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%10222065 Neurotransmitter release cycle Slc1a1 Slc18a3 Slc38a2 Slc1a7 Slc1a6 Gls2 Slc6a12 Stx1a Dnajc5 Slc22a2 Vamp2 Slc22a1 Slc32a1 Slc6a11 Slc6a13 Aldh5a1 Naaa Slc17a7 Slc6a1 Abat Syn3 Syn2 Syn1 Cask Chat Lin7a Lin7b Lin7c Gls Gad1 Gad2 Hspa8 Apba1 Arl6ip5 Rab3a Slc5a7 Slc1a3 Slc1a2 Rims1 Maoa Tspoap1 Syt1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Unc13b Snap25 Slc18a2 Cplx1 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%10224009 Calnexin calreticulin cycle Rps27a Canx Calr Uba52 Pdia3 Ubb Ubc PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 96%10223405 Platelet sensitization by LDL Ppp2r5b Ppp2r5a Ppp2cb Ppp2ca Mapk14 Ptpn6 Ppp2r1b Ppp2r1a Fgr Ppp2r5e Pla2g4a Apob Ptpn11 Ppp2r5d Pecam1 Lrp8 TRIGLYCERIDE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10223079 Triglyceride catabolism Fabp9 Fabp5 Fabp1 Fabp2 Fabp3 Fabp4 Fabp7 Fabp6 Pnpla5 Pnpla4 FABP12 Gpd2 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-RNO-1855229.1 IP6 and IP7 transport between cytosol and nucleus Nup133 Nup210 Nup155 Nup153 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 96%10223039 Signaling by FGFR3 Ppp2cb Ppp2ca Uba52 Frs2 Plcg1 Frs3 Fgf2 Fgf1 Fgf4 Fgf5 Ubb Fgf8 Fgfr3 Ubc Fgf9 Fgf16 Fgf17 Pik3ca Shc1 Fgf18 Braf Ppp2r1a Mapk3 Src Spry2 Pik3r1 Mknk1 Cbl Nras Mapk1 Rps27a Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Galnt3 Gab1 REELIN SIGNALLING PATHWAY%REACTOME%R-RNO-8866376.1 Reelin signalling pathway Fyn Vldlr Sh3kbp1 Reln Dab1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-RNO-159231.1 Transport of Mature mRNA Derived from an Intronless Transcript Nup133 Cpsf1 Nup210 Ncbp2 Cpsf2 Nup155 Ncbp1 Cpsf3 Nup153 Nup93 Nup50 Alyref Nxf1 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Fip1l1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Sympk Aaas Eif4e Ranbp2 Cpsf4 Nup214 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-RNO-389357.1 CD28 dependent PI3K Akt signaling Pik3r5 Pik3cg Map3k8 Pdpk1 Cd28 Rictor Cd86 Cd80 Prr5 Map3k14 Trib3 Lck Mapkap1 Them4 Pik3ca Mtor Akt3 Akt2 Akt1 Pik3r1 Pik3cb Pik3r2 Fyn Pik3r3 Pik3cd Pik3r6 Mlst8 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 96%10222937 Downregulation of SMAD2 3:SMAD4 transcriptional activity Tgif1 Tgif2 Atp1b4 Parp1 Uba52 Ppm1a Smad2 Ube2d1 Ncor2 Smad3 Smad4 Trim33 Mapk3 Ski Mapk1 Rps27a Ube2d3 Ubb Usp9x Hdac1 Ubc Skil Smurf2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224163 PI3K events in ERBB4 signaling Pik3ca Ereg Nrg2 Nrg3 Hbegf Btc Pik3r1 SIGNALING BY WNT%REACTOME%R-RNO-195721.1 Signaling by WNT Gsk3b Ctnnb1 Sox3 Wnt5a Sox9 Sox7 Gnat2 Sox6 Pygo2 Sox4 Pygo1 Men1 Tle4 Tle3 Tle2 Tle1 Tnks2 Hecw1 Xiap Klhl12 Axin1 Axin2 Rnf43 Tcf7 Dvl1 Dvl2 Wnt11 Gnao1 Dvl3 Nlk Sox13 Tcf7l1 Fzd3 Wnt1 Tcf7l2 Fzd1 Fzd2 Fzd5 Fzd4 Fzd6 Sox17 Fzd8 Bcl9l Bcl9 Cdc73 Rnf146 Cby1 Znrf3 Ctbp1 Kras Amer1 Tnks Rspo1 Rspo3 Rspo2 Rspo4 Usp34 Tert Chd8 Wnt8b Smurf2 Wnt8a Ppp2r5b Sry3 Ppp2r5a Lef1 Dact1 Map3k7 Sry Leo1 Ryk Ctnnbip1 Apc Lgr5 Lgr6 Frat2 Pip5k1b Frat1 Ppp2r5e Daam1 Ppp3ca Ppp3cb Nfatc1 Ppp3r1 Prkcb Ap2s1 Pfn1 Ap2a2 Ap2a1 Ap2b1 Rac3 Rac1 Psma4 Psma3 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Gng10-ps1 Snx3 Zranb1 Ppp2cb Ppp2ca Prkcg Prkca Calm3 Ppp2r5d Gng3 Gng5 Gng4 Gng7 Gng8 Gngt1 Ppp2r1b Ppp2r1a Gnb2 Gnb1 Rhoa Gnb4 Gnb3 Gnb5 Gng11 Camk2a Arrb2 Vps26a Vps35 Vps29 Wnt10a Wnt10b Wls Fzd7 Wnt9a Wnt9b Wnt7a Tmed5 Wnt5b Ror1 Ror2 Wnt6 Wnt2 Wnt4 Wnt2b Wnt16 Prickle1 Pard6a Rac2 Crebbp Kmt2b Ctbp2 Csnk2a2 Csnk2a1 Dkk4 Kremen2 Kremen1 Hdac1 Wdr5 Lrp6 Ash2l Sost Dkk1 Dkk2 Csnk2b Cav1 Smarca4 Ep300 Rbbp5 Pde6g Xpo1 Pde6a Pde6b Csnk1a1 Ap2m1 Clta Cltb Cltc Rbx1 Smurf1 Cul3 Csnk1e Ywhaz BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-RNO-73929.1 Base-Excision Repair, AP Site Formation Hist1h2ai Neil2 H2ac18 Neil1 Hist1h2bq Terf2 Neil3 Acd Terf1 Mpg Ogg1 H2aj Terf2ip Mutyh Tinf2 H2ab2 Pot1 Hist3h2ba H2ac4 ENSRNOG00000068602 Mbd4 Smug1 Nthl1 Tdg Ung ENSRNOG00000066901 H2az2 H2bc4 Hist1h4m H2bc1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 96%10222977 Glutathione synthesis and recycling Cndp2 Gclm Chac1 Ggt1 Ggt5 Chac2 Ggt7 Ggt6 Ggct Gss Gclc Oplah MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10222633 Mitotic Spindle Checkpoint Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Ppp2r5b Ppp2r5a Ppp1cc Ppp2r5e Ube2s Pafah1b1 Ube2c Zw10 Knl1 Cdc27 Cdc26 Ska2 Cdc23 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Mad2l1 Nuf2 Cdca8 Anapc10 Ube2d1 Incenp Bub1b Dync1i2 Ndel1 Anapc16 Dync1i1 Cenpc Anapc15 Cenpa Aurkb B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Anapc5 Cenpt Cenpq Anapc4 Cenpp Anapc1 Cenpo Anapc2 Cenpn Cenpm Mis12 Anapc7 Cenpl Cenpk Cenpi Ube2e1 Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Cdc16 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ranbp2 Ckap5 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-RNO-6799990.1 Metal sequestration by antimicrobial proteins Ltf S100a9 S100a8 Lcn2 MITOTIC METAPHASE AND ANAPHASE%REACTOME%R-RNO-2555396.1 Mitotic Metaphase and Anaphase Spdl1 Nup133 Nup155 Bub1 Itgb3bp Zwilch Emd Tuba1b Ppp2r5b Ppp2r5a Vrk2 Ppp1cc Ppp2r5e Tuba1a Kpnb1 Tuba1c Tubal3 Rcc1 Tuba4a Chmp2b Cc2d1b Spast Tubb2b Tubb2a Ist1 Hdac8 Chmp3 Vrk1 Chmp7 Chmp6 Lmna Vps4a Sirt2 Tuba8 Chmp4c Tuba3b Chmp4bl1 Tubb6 Tubb3 Tubb1 Banf1 Ran Ankle2 Tubb4b Tubb4a Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Chmp2a Psmb6 Ppp2r2a Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 Cdk1 Lbr Ppp2cb Ppp2ca Ppp2r5d Ppp2r1b Ppp2r1a Wapl Pds5b Pds5a Cdca5 Ube2i Espl1 Smc3 Sumo1 Stag2 Stag1 Smc1a Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Nup93 Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Nup35 Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Pom121 Sgo2 Nup205 Sgo1 Nup107 Sec13 Kif2a Kif2b Kif2c Nup188 Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Ndc1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ccnb2 Ranbp2 Ckap5 PHENYLALANINE METABOLISM%REACTOME%R-RNO-8964208.1 Phenylalanine metabolism Asrgl1 Pcbd1 Qdpr Kyat1 Pah Il4i1 REGULATION OF KIT SIGNALING%REACTOME DATABASE ID RELEASE 96%10223381 Regulation of KIT signaling Ptpn6 Lyn Yes1 Kitlg Src Cbl Prkca Sh2b2 Grb2 Fyn Sos1 Lck Kit PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%10223683 Prostacyclin signalling through prostacyclin receptor Ptgir TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-RNO-416993.1 Trafficking of GluR2-containing AMPA receptors Tspan7 Grip2 Grip1 Prkcb Prkcg Ap2s1 Prkca Gria4 Gria3 Ap2a2 Gria2 Ap2a1 Nsf Ap2b1 Pick1 Gria1 Ap2m1 MRNA EDITING%REACTOME%R-RNO-75072.1 mRNA Editing Apobec1 Adarb1 Adar A1cf Apobec4 Apobec2 Apobec3 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 96%10222527 Activation of caspases through apoptosome-mediated cleavage Casp3 Casp7 Cycsl2 Casp9 Apaf1 Cycs Xiap EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 96%10222139 Eukaryotic Translation Initiation LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Eif5 Rps14 Eif2b3 Rps15 Eif2b2 Rps16 Eif2s3 Rps17 Eif2b5 Rpl4 Rps15a Eif2b4 Rpl5 Rps18 Eif2s2 Rpl3 Rps19 Eif2b1 Rps27 Pabpc1 Eif2s1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Eif4h Rpl7 Rps26-ps13 Eif3m Eif3j Eif3i Rpl30 Eif3l LOC134486107 Eif3k Rpl31 Eif3f Rpl32 Eif3e Eif3h Rpl34 Eif3g Rpl36al1 Eif3b Eif3a Rpl39l1 Eif3d Rpl24 Eif3c Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Eif1ax Eif4a2 Eif4a1 Eif5b Fau Eif4ebp1 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 Eif4e BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10225261 Blood group systems biosynthesis B3galt1 Fut2 Fut1 Fut4 B4galnt2 Fut7 Fut9 B3galt5 B3galt4 St6galnac6 Abo2 St3gal6 St3gal4 St3gal3 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-RNO-8951430.1 RUNX3 regulates WNT signaling Runx3 Lef1 Tcf7l1 Tcf7l2 Ctnnb1 Tcf7 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 96%10224725 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Hist1h2ai H2aj Kdm4c Ncoa2 H2ab2 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 Ar H2bc4 Hist1h4m Kdm1a H2bc1 Pkn1 FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 96%10224919 FGFR2 alternative splicing Polr2j Ncbp2 Ncbp1 Hnrnpa1 Hnrnph1 Gtf2f2 Rbfox2 Gtf2f1 Esrp2 Esrp1 Tial1 Ptbp1 Tia1 Polr2c Hnrnpf Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2i MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-RNO-193993.1 Mineralocorticoid biosynthesis Hsd3b1 Hsd3b5-ps1 Hsd3b Lhb Cga Hsd3b6 Cyp21 Hsd3b5 Cyp11b3 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224033 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling Irf7 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%10224679 Transcriptional regulation by small RNAs Polr2j Hist1h2ai H2ac18 Ago2 Ago1 Hist1h2bq Ipo8 H2aj H2ab2 H3-3b Hist3h2ba Tnrc6a H2ac4 ENSRNOG00000068602 Polr2c Polr2a Polr2b H2bc18 Polr2g Polr2h ENSRNOG00000066901 H2az2 Polr2e Ran Polr2f H2bc4 Hist1h4m Polr2i H2bc1 TP53 REGULATES METABOLIC GENES%REACTOME%R-RNO-5628897.1 TP53 Regulates Metabolic Genes Ywhag Cox5a Cox5b Ndufa4 Ddit4 Higd1c Prkab2 Prkab1 Prdx2 Prdx5 Gls2 Cox4i1 Cox4i2 Prdx1 Sesn2 Txnrd1 Sesn1 Akt3 Sesn3 Akt2 Akt1 Gsr Tigar Cox6a1 Tsc2 Cox6a2 Tsc1 Sfn Cox6c2 Cox7a1 Cox7a2 Gls Cox7a2l Cox6b1 Cox6b2 G6pdx Lamtor3 Lamtor2 Txn Ywhae Rptor RragB Prkaa1 Mt-co3 Gpi Prkaa2 Mt-co2 Cycsl2 Mtor Cox8a Rheb Cox8c Cox7b Slc38a9 Lamtor5 Cox7c Lamtor4 Prkag3 Rraga Prkag1 Mt-co1 Prkag2 Lamtor1 Rragc Ywhaq Rragd Ywhah Cycs Ywhab Mlst8 Gpx2 Ywhaz AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-RNO-211163.1 AKT-mediated inactivation of FOXO1A Foxo1 Akt3 Akt2 Akt1 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%10222171 RNA Polymerase I Transcription Initiation Gtf2h2 Gtf2h1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Rbbp4 Ercc3 Rbbp7 Ttf1 Polr1c Mnat1 Hdac1 Hdac2 Tbp Polr1b Polr1a Ccnh Polr1f Polr1g Polr1e Polr1h Chd3 Chd4 Taf1d Rrn3 Taf1a Taf1c Taf1b Mta1 Mta2 Polr2h Mta3 Mbd3 Polr2e Polr2f Ercc6 Ubtf Gatad2a Gatad2b CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME%R-RNO-373076.1 Class A 1 (Rhodopsin-like receptors) Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 App Ednrb Ednra Rrh Ptgdr Htr4 Apln Trhr Htr6 Oprd1 Htr7 C3ar1 Galr2 Galr3 Galr1 Cmklr1 Avpr2 Sstr5 Sstr4 Sstr3 Kel Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Rxfp1 Htr5a Tbxa2r Gpr183 Ppbp Fpr1 Gnrh1 Nmbr Fpr2 Ccr10 C3 Nln C5 Ptgfr Pnoc Ppy Nmb Oxtr Lpar6 Xcr1 Gpr18 Grpr Gpr17 Nms Nmu Cckar Npbwr1 Fshb Gpbar1 Nmur2 Gnrhr Nmur1 Ntsr2 Ntsr1 Brs3 Ptger4 Ptger2 Ptger3 Fshr Ptger1 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 Ccr3 Gpr132 Edn1 Edn2 Edn3 Cckbr Mtnr1b Agtr1 Agtr2 F2 Gpha2 Gpr37 Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Taar3 Taar2 Avp Taar5 Rgr Taar1 Npb Gpr143 Grp Opn1mw Kiss1r Ccl19 Ccl17 Gphb5 Nps Mc4r Ccl11 Ccl12 Ptafr Npw Npy Ptgdr2 Rho Pf4 Cx3cl1 Fpr2l3 Cysltr2 Cysltr1 Prok2 Gpr4 Ptgdrl Ccl27 Npsr1 Prok1 P2ry10 Pdyn Mc3r P2ry13 P2ry12 Ccl20 Gpr55 Ccl21 P2ry14 F2rl1 Fpr2l1 F2rl2 F2rl3 Hcar1 Prokr2 Adra2b Hcar2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Gpr65 Oprm1 Gpr68 Cxcr4 Cxcr5 Oprl1 Adrb2 Adrb1 Adra1b Adrb3 Adra1a Adra1d Lhcgr Uts2 Mc5r Prlh Pomc Tacr1 Tacr3 Tacr2 Anxa1 Cxcl11 Hebp1 Cxcl12 Cxcl10 C5ar2 F2r C5ar1 Ffar3 Aplnr Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng1 Chrm1 Hrh1 Chrm3 Chrm2 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Ccrl2 Gper1 Oxgr1 Adra2a Opn5 Adora2b Sucnr1 Lhb Pyy Adora2a Cga Adora1 Adra2c Adora3 Rln3 Ltb4r2 Rln1 Cxcl16 Cxcl13 Opn1sw Prlhr Oxt Ece1 Ece2 Trh P2ry2 Npy5r Htr2a Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Insl3 Ptgir Psap Htr1d Htr1f Xcl1 Htr1b Htr1a Agt Kiss1 Tshr Ccl9 P2ry6 Cxcl9 Ccl7 P2ry4 Ccl6 Ccl5 P2ry1 Ccl4 Ccl3 Ccl1 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Uts2b Npffr1 Npffr2 Gpr37l1 Npff Ackr3 Hcrtr2 Ackr4 Hcrtr1 Cck Qrfprl Cnr1 Qrfpr Ackr2 Qrfp Cnr2 Hcrt Uts2r Taar8c Sst Oprk1 Tshb PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%10223635 Peroxisomal lipid metabolism Acoxl Phyh Abcd1 Amacr Eci2 Hacl1 Mlycd Scp2 Crat Acox1 Acox2 Ehhadh Acox3 Acaa1b Hsd17b4 Hao2 Pecr Acbd5 Slc27a2 Aldh3a2 Decr2 Crot Acbd4 Nudt19 Acot4 Acot8 COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 96%10224229 Collagen formation Plod1 Plod2 Loxl2 Adamts3 Bmp1 Adamts2 Loxl1 Loxl4 Col15a1 Loxl3 Col13a1 Col19a1 Ctsl Lox Col25a1 Col4a1 Col4a2 Adamts14 P4hb Col7a1 Tll2 Tll1 Ctsb Ctss Gpr162 Col14a1 Col10a1 Ppib Col1a2 Mmp7 Col3a1 Col28a1 Mmp3 Col22a1 Col5a2 Col5a3 Col24a1 Mmp9 Col4a4 Col5a1 Col9a2 Col9a3 Pcolce Col20a1 Col11a1 Col11a2 Colgalt1 P3h2 P3h1 Pxdn Crtap Col18a1 Pcolce2 Colgalt2 Col2a1 Col27a1 Col6a2 Serpinh1 Col23a1 Mmp20 Col6a5 Col6a6 Col26a1 Col4a5 Col6a3 Mmp13 Col8a1 Col4a6 Col8a2 Plod3 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-RNO-5263617.1 Metabolism of ingested MeSeO2H into MeSeH Txnrd1 SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 96%10224471 Sensory perception of taste Tas2r16 Tas2r13 Tas2r136 Tas2r140 Tas2r105 Tas2r107 Tas2r119 Tas2r39 Tas2r4 Tas2r38 Tas2r3 Tas2r7 Gnat3 Itpr3 Scnn1a Scnn1b Gnb1 Scnn1g Gnb3 Tas1r2 Tas1r1 Tas2r120 Tas1r3 Tas2r40 Tas2r41 SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 96%10224771 SHC-mediated cascade:FGFR2 Fgf16 Fgf17 Shc1 Fgf18 Fgf10 Nras Grb2 Kras Sos1 Hras Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgf7 Fgf9 Fgfr2 ION CHANNEL TRANSPORT%REACTOME%R-RNO-983712.1 Ion channel transport Mcoln2 Clcn6 Clcn7 Clcn4 Clcn5 Calm3 Atp2a1 Atp2a3 Atp7a Atp2a2 Trpc7 Trpc3 Atp2b1 Camk2g Atp2b4 Camk2d Atp2b3 Camk2b Sri Camk2a Wwp1 Atp1b1 Atp1b3 Atp1b2 Ryr2 Ryr1 Fkbp1b Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Clic2 Trdn Pln Asph Stom Trpc1 Raf1 Ano6 Ano5 Clcn2 Clcn1 Ano10 Ttyh3 Ttyh1 Ttyh2 Slc17a3 Trpc4ap Atp9b Atp9a Best4 Atp6v0b Atp6v0a4 Best1 Best3 Atp6v1g3 Atp6v0e2 Atp6v1c2 Best2 Atp6v0a1 Atp6v1c1 Atp7b Clca1 Atp6v0c Clca2 Clca4 Trpc5 Trpc4 Atp6ap1 Stoml3 Unc80 Atp6v1e2 Atp6v1e1 Tcirg1 Atp2c1 Atp6v1a Atp6v1b2 Atp2c2 Scnn1a Atp6v0d2 Atp6v0d1 Atp6v1b1 Scnn1b Atp6v0e1 Unc79 Atp6v1g2 Scnn1g Atp6v1g1 Lrrk1 Atp6v1f Rps27a Trpa1 Atp6v1d Tpcn1 Bsnd Mcoln1 Atp4a Atp4b Trpm2 Trpm1 Nek4 Uba52 Ano9 Ano8 Trpm8 Trpm7 Ano7 Trpm4 Ano4 Sgk1 Trpm3 Ano3 Trpm6 Ano2 Ano1 Sgk3 Sgk2 Asic5 Asic4 Atp10a Ubb Atp10b Atp10d Ubc Asic1 Asic3 Asic2 Atp11b Atp11a Atp11c Atp13a1 Atp8b2 Atp8b1 Atp8b4 Atp8b3 Atp13a2 Atp13a4 Atp13a5 Atp12a Trpv5 Trpv4 Trpv6 Trpv1 Trpv3 Trpv2 Nalcn Tsc22d3 Clcnkb Clcnka Mcoln3 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-RNO-400685.1 Sema4D in semaphorin signaling Rhoc Erbb2 Rac1 Rnd1 Rhob Rras Met Arhgef11 Rhoa Sema4d Arhgap35 Plxnb1 Arhgef12 Rock2 Rock1 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%10223323 Formation of the beta-catenin:TCF transactivating complex Lef1 Leo1 Crebbp Ctnnb1 Kmt2b Pygo2 Pygo1 Men1 Tle4 Tle3 Tle2 Tle1 Hdac1 Tcf7 Wdr5 Ash2l Tcf7l1 Tcf7l2 Smarca4 Ep300 Bcl9l Bcl9 Cdc73 Rbbp5 Tert INTERLEUKIN-15 SIGNALING%REACTOME%R-RNO-8983432.1 Interleukin-15 signaling Jak3 Grb2 Shc1 Sos1 Stat3 Il2rb Il15 Il15ra Sos2 Stat5a Stat5b PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 96%10223333 Phosphorylation of CD3 and TCR zeta chains Pag1 Ptprc RT1-Db2 Cd3g Cd247 Csk RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck Ptpn22 RT1-Ba RT1-Bb ENSRNOG00000065955 Trbv16 RT1-Da ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%10223445 Acetylcholine Neurotransmitter Release Cycle Rims1 Tspoap1 Syt1 Stx1a Ppfia3 Ppfia2 Ppfia4 Chat Ppfia1 Stxbp1 Unc13b Snap25 Cplx1 Slc18a3 Vamp2 Rab3a Slc5a7 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-RNO-5626978.1 TNFR1-mediated ceramide production Nsmaf Rack1 Smpd2 Smpd3 Tnf Tnfrsf1a COMPLEX III ASSEMBLY%REACTOME%R-RNO-9865881.1 Complex III assembly Nfs1 Uqcrb Fxn LOC120097699 Uqcrh Uqcr10 Ttc19 Hspa9 Hscb Mt-cyb Uqcrfs1 Lyrm7 Iscu Uqcrc2 Uqcrc1 Uqcrq Cyc1 Lyrm4 PTEN REGULATION%REACTOME%R-RNO-6807070.1 PTEN Regulation Suz12 Eed Nedd4 Rbbp4 Rbbp7 Tnks2 Xiap Usp7 Mkrn1 Stub1 Rnf146 Tnks Wwp2 Otud3 Pten Usp13 Lamtor3 Lamtor2 Hdac2 Ring1 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Prex2 Csnk2a2 Trim27 Csnk2a1 Bmi1 Hdac1 Maf1 Mecom Sall4 Csnk2b Psma4 Akt3 Psma3 Akt2 Akt1 Psma6 Psma5 Rnf2 Psma2 Psma1 Chd3 Rps27a Chd4 Psmd12 Psmd11 Psmd14 Psmd13 Mta1 Mta2 Mta3 Mbd3 Psmb5 Gatad2a Psmb4 Gatad2b Psmb7 Pml Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Frk Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Rptor Psmd6 RragB Psmd8 Psmd2 Mtor Psmd1 Adrm1 Rheb Slc38a9 Lamtor5 Lamtor4 Rraga Lamtor1 Rragc Rragd Ezh2 Mlst8 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%R-RNO-933541.1 TRAF6 mediated IRF7 activation Crebbp Irf3 Irf7 Ep300 ARACHIDONATE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222329 Arachidonate metabolism Alox12b Cyp8b1 Akr1c18 Abcc1 Akr1c12l1 Akr1c19 Akr1c21 Ggt1 Ggt5 Akr1c3l1 Cyp2u1 Akr1c12 Hpgds Akr1c1 Akr1c13 Ltc4s Dpep1 Akr1c9 Dpep2 Faah Pon2 Alox15b Alox12 Alox5ap Cyp1b1 Gpx4 Alox5 Lta4h Alox15 Cyp2c66 Cyp2c11 Cbr1 Cyp1a1 Tbxas1 Ephx2 Ptges Ptgds Cyp1a2 Ptgis Ptges2 Awat1 Ptgs1 Ptgs2 Pon3 Pon1 Ptges3 Mapkapk2 Cyp2j16 Cyp4f39 Cyp2j3 Cyp4f1 Cyp4a14 Pla2g4a Cyp4f3 Cyp4a12 Cyp4f40 Cyp4b1 Cyp4f4 Cyp4a10 Cyp4a2 Gpx2 Aloxe3 Gpx1 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-RNO-3928662.1 EPHB-mediated forward signaling Grin1 Grin2b Arpc3 Arpc2 Actb Arpc5 Arpc4 Rasa1 Actg1 Rock2 Rock1 Tiam1 Pak1 Rac1 Ptk2 Lyn Yes1 Src Rhoa Arpc1b Actr2 Arpc1a Actr3 Fyn Itsn1 Hras Arhgef28 Cdc42 Sdc2 Kalrn SEPARATION OF SISTER CHROMATIDS%REACTOME%R-RNO-2467813.1 Separation of Sister Chromatids Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Wapl Pds5b Pds5a Cdca5 Ppp2r5b Ppp2r5a Ppp1cc Ppp2r5e Espl1 Hdac8 Smc3 Stag2 Stag1 Smc1a Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Pafah1b1 Ube2c Zw10 Psmd14 Knl1 Psmd13 Cdc27 Cdc26 Ska2 Cdc23 Ska1 Zwint Cdc20 Rps27 Psmb5 Rcc2 Psmb4 Kif18a Psmb7 Nudc Psmb6 Dync1h1 Spc24 Psmb1 Spc25 Psmb3 Xpo1 Psmb2 Uba52 Mad2l1 Nuf2 Cdca8 Anapc10 Ube2d1 Incenp Bub1b Dync1i2 Ndel1 Anapc16 Dync1i1 Psma7 Cenpc Anapc15 Cenpa Aurkb B9d2 Psmc5 Ska2l1 Psmc2 Taok1 Psmc1 Nde1 Psmc4 Mad1l1 Psmc3 Cenpu Anapc5 Cenpt Cenpq Anapc4 Cenpp Anapc1 Cenpo Anapc2 Cenpn Cenpm Ubb Mis12 Anapc7 Cenpl Ubc Cenpk Cenpi Ube2e1 Nup98 Cenph Psmb6l1 Cenpf Cenpe Clasp1 Psmd7 Clasp2 Rangap1 Psmd6 Nup37 Psmd8 Clip1 Plk1 Sgo2 Psmd2 Sgo1 Pttg1 Nup107 Psmd1 Kif2a Sec13 Adrm1 Kif2b Kif2c Dync1li2 Cdc16 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ranbp2 Ckap5 HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-RNO-3371571.1 HSF1-dependent transactivation Hsbp1 Rptor Fkbp4 Hspa2 Hsp90ab1 Ptges3 Crebbp Mtor Hspb8 Hspa8 Ep300 Hsp90aa1 Hsf1 Akt1s1 Hspa1b Camk2g Hspa1a Camk2d Camk2b Dnajb1 Cryab Hspa1l Mlst8 Camk2a THE FATTY ACID CYCLING MODEL%REACTOME%R-RNO-167826.1 The fatty acid cycling model Slc25a14 Ucp1 Ucp2 Ucp3 Slc25a27 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-RNO-2173796.1 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription Ccnc E2f5 Uba52 Furin Tfdp2 Tfdp1 Smad2 Smad3 Smad4 Mapk3 Smad7 Rbl1 Ccnk Mapk1 Rps27a Ccnt2 Men1 Cdk9 Wwtr1 Sp1 Ubb Ubc Rnf111 E2f4 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 96%10222623 Amine Oxidase reactions Maob Maoa Smox ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224961 ERBB2 Activates PTK6 Signaling Egfr Erbb2 Egf Erbb3 Ereg Nrg2 Nrg3 Hbegf Btc Ptk6 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-RNO-418594.1 G alpha (i) signalling events Rgs3 Rgs1 Rgs8 Rgs7 Pcp2 Gpsm3 Gpsm2 Gpsm1 Rgs21 Rgs18 Rgs19 Rgs13 Rgs14 Gnat2 Rgs12 Ccr1l1 Lpar5 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 App Rrh Apln Tas2r39 Oprd1 Tas2r38 C3ar1 Galr2 Galr3 Galr1 Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Rxfp3 Htr5a Gpr183 Ppbp Fpr1 Tas1r2 Tas1r1 Fpr2 Ccr10 Tas1r3 C3 C5 Pnoc Tas2r16 Tas2r13 Ppy Tas2r135 Tas2r136 Gpr18 Gpr17 Nms Tas2r140 Nmu Tas2r145 Npbwr1 Nmur2 Nmur1 Tas2r4 Tas2r3 Tas2r7 Gabbr1 Ptger3 Gabbr2 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 Ccr3 Mtnr1b Agtr2 Gpr37 Gal Penk Rgr Npb Opn1mw Ccl19 Ccl11 Npw Npy Ptgdr2 Rho Pf4 Cx3cl1 Fpr2l3 Ccl27 Plcb4 Plcb3 Mapk1 Pla2g4a Pdyn Plcb2 P2ry13 Plcb1 P2ry12 Ccl20 Ppp1r1b Gng10-ps1 Gpr55 Adcy3 Ccl21 Adcy4 P2ry14 Adcy1 Adcy2 Tas2r40 Camkk1 Adcy7 Fpr2l1 Tas2r41 Camkk2 Adcy8 Ppp1ca Adcy5 Adcy6 Hcar1 Ppp2cb Adra2b Ppp2ca Adcy9 Hcar2 Pde4a Cxcr1 Pde4b Cxcr2 Prkaca Cxcr3 Prkacb Prkcg Npy1r Prkcd Oprm1 Gnai2 Gnai1 Cxcr4 Prkca Cxcr5 Gnai3 Oprl1 Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Ppp2r5d Gng3 Grk2 Gnal Pomc Gng5 Gng4 Pde4c Anxa1 Gnaq Cxcl11 Gng7 Hebp1 Pde4d Gng8 Gngt1 Cxcl12 Casr Gnat3 Prkar2a Cxcl10 Prkar2b Ppp2r1b Ppp2r1a C5ar1 Cdk5 Pde1b Aplnr Pde1c Bdkrb2 Gnb2 Bdkrb1 Gnb1 Src Pde1a Gnb4 Kng1 Gnb3 Gnb5 Gng11 Chrm2 Hrh4 Chrm4 Drd3 Drd4 Opn3 Pmch Gper1 Oxgr1 Adra2a Opn5 Sucnr1 Pyy Adora1 Adra2c Adora3 Rln3 Cxcl16 Cxcl13 Tas2r119 Opn1sw Npy5r Grm3 Grm2 Grm4 Grm7 Grm6 Grm8 Npy4r Cx3cr1 Psap Htr1d Htr1f Tas2r120 Htr1b Agt Ccl9 Cxcl9 P2ry4 Ccl6 Ccl5 Ccl4 Ccl1 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Tas2r105 Tas2r107 Gpr37l1 Ackr3 Cnr1 Cnr2 Sst Oprk1 Rgs9 Gnat1 Rgs20 Rgs17 Rgs16 Rgs4 Rgs5 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-RNO-442755.1 Activation of NMDA receptors and postsynaptic events Grin1 Grin2d Grin2c Rps6ka6 Grin2b Camk1 Prkaca Prkacb Rps6ka3 Camk4 Rps6ka1 Prkar1a Prkar1b Rps6ka2 Calm3 Creb1 Prkar2a Prkar2b Grin3a Grin2a Lrrc7 Gria4 Gria3 Camk2g Camk2d Gria2 Camk2b Dlg1 Dlg2 Gria1 Actn2 Camkk1 Dlg3 Dlg4 Camk2a Camkk2 Nefl CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-RNO-8856828.1 Clathrin-mediated endocytosis Arf6 Ereg Wnt5a Btc Ttgn1 Igf2r M6pr Vamp3 Arfgap1 Adrb2 Vamp4 Nedd8 Grk2 Tacr1 Itsn2 Hgs Dvl2 Slc2a8 Fzd4 Hbegf Grb2 Stam2 Gps1 Apob Chrm2 Vamp2 Tgfa Trip10 Areg Lrp2 Arrb2 Arrb1 Il7r Cops4 Arpc3 Cops2 Arpc2 Cd3g Arpc5 Arpc4 Picalm Eps15 Cd3d Dnm2 Cd4 Avpr2 Egfr Syt1 Actr2 Ap2s1 Arpc1a Actr3 Dnm3 Ap2a2 Ap2a1 Ap2b1 Sh3gl2 Slc18a3 Ocrl Egf Bin1 Synj1 Snx18 Ston1 Ston2 Eps15l1 Tor1a Tor1b Scarb2 Pip5k1c Ldlr Fnbp1 Cops3 Cops6 Cops8 Aak1 Synj2 Rps27a Syt11 Tf Itsn1 Sh3gl3 Sh3kbp1 Tfrc Dnajc6 Agtr1 Sh3gl1 Fnbp1l Pik3c2a Ldlrap1 Fcho1 Vamp7 Fcho2 Vamp8 Uba52 Rab5a Necap2 Necap1 Avp Hspa8 Hip1r Agfg1 Snx9 Cops7a Cops7b Hip1 Gapvd1 Gak Ubb Ubc Ap2m1 Pacsin1 Clta Pacsin3 Cltb Pacsin2 Cltc Dab2 Grk3 Dnm1 Amph Snap91 Syt2 Syt9 Syt8 Ubqln2 Cbl Ubqln1 Epn2 Epn1 Reps1 Reps2 Cops5 Stam Rab5c Rab5b Cftr NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224043 Negative regulation of FGFR2 signaling Ppp2cb Ppp2ca Uba52 Frs2 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Ubb Fgf8 Fgf7 Ubc Fgf9 Fgfr2 Fgf16 Fgf17 Fgf18 Braf Ppp2r1a Fgf10 Mapk3 Src Spry2 Mknk1 Cbl Mapk1 Rps27a Grb2 Ptpn11 Fgf20 Fgf23 Fgf22 SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 96%10224251 Synthesis of PI Cds1 Cdipt Pitpnm2 Pitpnm3 Pitpnm1 CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 96%10222757 Cytoprotection by HMOX1 Cox7a2 Cox5a Cox5b Fabp1 Ncoa2 Blvrb Hmox2 Blvra Tbl1x Ndufa4 Crebbp Abcc1 Hmox1 Cox7a2l Hba1 Cox6b1 Higd1c Hbb Ppara Cox6b2 Sin3a Sin3b Hdac3 Alb Tbl1xr1 Cox4i1 Cox4i2 Hm13 Mt-co3 Mt-co2 Cycsl2 Ncor2 Carm1 Cox8a Tgs1 Cox8c Cox7b Cox7c Smarcd3 Mt-co1 Cox6a1 Cox6a2 Cycs Med1 Cox6c2 Cox7a1 Rxra HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 96%10224553 HSP90 chaperone cycle for SHRs Stip1 Dync1h1 Actr1a Pgr Dctn1 Actr10 Dctn2 Dync1i2 Dctn4 Dync1i1 Hspa8 Dnaja1 Hspa1b Hspa1a Hspa1l Fkbp4 Hspa2 Hsp90ab1 Fkbp5 Ptges3 Dync1li2 Hsp90aa1 Dync1li1 Dnaja2 Dnaja4 Dynll1 Dynll2 Dnajb1 Ar Nr3c2 Nr3c1 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-RNO-9018679.1 Biosynthesis of EPA-derived SPMs Gpx4 Ptgs2 Hpgd Alox5 Lta4h Alox15 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 96%10224115 ISG15 antiviral mechanism Eif2ak2 Ube2n Stat1 Isg15 Nedd4 Irf3 Rig1 Plcg1 Mapk3 Becn1 Flnb Usp18 Ube2l6 Ppm1b Mx2 Arih1 Trim25 Uba7 Ube2e1 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 96%10221955 Transcriptional Regulation by TP53 Ywhag Cox5a Zfp385a Cox5b Pdpk1 Ttc5 Pou4f1 Rbbp4 Rbbp7 Pou4f2 Prkab2 Prkab1 Gls2 Cox4i1 Cox4i2 Gadd45a LOC134478826 Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe Polr2j Ctdp1 Gtf2h2 Gtf2h1 Supt4h1 Gtf2f2 Gtf2f1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Banp Map2k6 Lamtor3 Lamtor2 Txn Hdac2 Mapk14 Cycsl2 Cpap Cycs Mapk11 Ywhab Gpx2 Ell Ccnk Tcea1 Ccnt2 Cdk13 Cdk12 Ssrp1 Eloa2l Eloa Txnrd1 Ccna1 Akt3 Akt2 Ccna2 Akt1 Gsr Chd3 Rps27a Ccne1 Chd4 Ccne2 Steap3 Tsc2 Tsc1 Mta2 Mbd3 Gatad2a Gatad2b Ccnb1 Uba52 Aurka Aurkb Cdk9 Rpa1 Rpa2 Rpa3 Ubb Chm Ubc Npm1 Cdkn1b Ywhae Rptor RragB Mt-co3 Mt-co2 Mtor Rheb Cdk2 Cdk1 Slc38a9 Lamtor5 Lamtor4 Rraga Mt-co1 Lamtor1 Rragc Rragd Stk11 Mlst8 Ppp2cb Ppp2ca Ddit4 Higd1c Plk2 Igfbp3 Tmem219 Btg2 Cdk5r1 Usp2 Brpf3 Usp7 Sesn2 Ppp2r1b Ppp2r1a Sesn1 Cnot11 Cdk5 Sesn3 Cnot10 Tp53rkb Tp53rka Tnks1bp1 Blm Wrn Dna2 Cox7a1 Cox7a2 Mre11 Eloc Kat5 Elob Nbn Cox7a2l Hus1 Atrip Cnot6l Rffl Chek1 Chek2 Cradd Pidd1 Rad9a Rad9b Bard1 Tpx2 Top3a Tp63 Tp53 Rad17 Rfc5 Ccng1 Rfc3 Rfc4 Pcna Ccnh Atm Kmt5a Rfc2 Atr Exo1 Rmi2 Rmi1 Brip1 Tp73 Jmy Rhno1 Dyrk2 Ndufa4 Cdk7 Rad50 Ehmt1 Daxx Ing2 Bax Ing5 Csnk2a2 Brd1 Topbp1 Rbbp8 Csnk2a1 Mnat1 Brca1 Prdx2 Brd7 Prdx5 Rad1 Hdac1 Smyd2 Prdx1 L3mbtl1 Csnk2b Tp53bp2 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Brpf1 Taf12 Tbp Taf4b Kat6a Taf7l-ps1 Ep300 Noc2l Meaf6 Taf8 Taf7 Tigar Taf6 Taf5 Hipk1 Cox6a1 Taf4 Cox6a2 Taf2 Taf1 Rabggta Rabggtb Ppp1r13l Sfn Ppp1r13b Plk3 Cox6c2 Pml Cnot3 Cnot2 Cnot1 Rnf34 Pip4k2b Cnot7 Pip4k2c Phf20 Cnot6 Pip4k2a Cnot4 Cnot9 Cnot8 Gls Sgk1 Cox6b1 Cox6b2 Rictor Prr5 G6pdx Casp2 Mapkap1 E2f7 E2f8 Prkaa1 Pip4p1 Prmt5 Prkaa2 Gpi Cdc25c Cox8a Cox8c Nuak1 Cox7b Cox7c Prkag3 Prkag1 Prkag2 Mdm4 Ywhaq Bnip3l Ywhah Mapkapk5 Ywhaz INTRA-GOLGI TRAFFIC%REACTOME%R-RNO-6811438.1 Intra-Golgi traffic Alpi Cog1 Cog2 Stx6 Rab33b Cog3 Ric1 Cyth2 Cog4 Cyth3 Stx5 Cyth4 Ykt6 Vti1a Vps45 Cyth1 Cog5 Cog6 Stx16 Cog7 Rgp1 Cog8 Napa Nsf Napb Napg Snap29 Bet1l Rab39a Rab36 Trip11 Akp3 Arf1 Alpp Alpg Gosr1 Gosr2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 96%10222377 RNA Polymerase III Transcription Initiation From Type 2 Promoter Gtf3c5 Bdp1 Tbp Polr3gl Crcp Polr3a Polr3d Brf1 Polr1c Polr3e Polr3b Polr3c Polr2h Polr3f Polr3g Polr2e Gtf3c2 Polr2f Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 96%10223437 EGFR interacts with phospholipase C-gamma Egfr Egf Ereg Tgfa Areg Plcg1 Hbegf Btc ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME DATABASE ID RELEASE 96%10223269 Estrogen-dependent nuclear events downstream of ESR-membrane signaling Creb1 Mapk1 Cdkn1b Xpo1 Uhmk1 Akt3 Akt2 Akt1 Foxo3 BIOTIN TRANSPORT AND METABOLISM%REACTOME%R-RNO-196780.1 Biotin transport and metabolism Slc5a6 Pc Hlcs Pcca Pccb Mccc1 Btd Mccc2 Acacb Acaca PI-3K CASCADE:FGFR4%REACTOME%R-RNO-5654720.1 PI-3K cascade:FGFR4 Fgf16 Fgf17 Pik3ca Fgf18 Fgf19 Frs2 Pik3r1 Grb2 Klb Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf8 Fgfr4 Fgf9 Gab1 PROTEIN REPAIR%REACTOME%R-RNO-5676934.1 Protein repair Txn Msra Pcmt1 Msrb1 Msrb3 Msrb2 SIGNALING BY NTRK2 (TRKB)%REACTOME%R-RNO-9006115.1 Signaling by NTRK2 (TRKB) Grb2 Fyn Dock3 Sos1 Bdnf Rac1 Frs2 Ntrk2 Plcg1 Ntf4 HOMOLOGY DIRECTED REPAIR%REACTOME%R-RNO-5693538.1 Homology Directed Repair Blm Wrn Dna2 Ppp4r2 Pias4 Ube2n Mre11 Ube2i Eme2 Kat5 Eme1 Timeless Nbn Gen1 Hus1 Atrip Lig3 Sirt6 Rad51c Rad51b Chek1 Ube2v2 Rad9a Rad9b Bard1 Top3a Palb2 Firrm Ppp4c Lig1 Clspn Rad17 Fen1 Parp2 Xrcc3 Parp1 Rfc5 Slx1b Pold2 Xrcc2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Xrcc1 Atm Rfc2 Atr Pold4 Tp53bp1 Pold3 Exo1 Mus81 Rmi2 Fignl1 Rmi1 Brip1 Abl1 Brcc3 ENSRNOG00000066901 Polq Herc2 Rnf168 ABRAXAS1 Sumo3 Rnf8 Rhno1 Slx4 Nsd2 Spidr Rad51 Rad50 Rad52 Ercc1 Ercc4 Babam1 Babam2 Topbp1 Rbbp8 Brca2 Brca1 Rad51ap1 Polk Hist1h2bq Uimc1 Rad1 Polh Ccna1 Ccna2 Hist3h2ba Rps27a H2bc4 Hist1h4m H2bc1 Uba52 Pole3 Pole2 Pole4 Rpa1 Rpa2 Ubb Rpa3 Ubc Pole Cdk2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-RNO-388841.1 Costimulation by the CD28 family Ywhag Suz12 Ddost Ppp2cb Eed Ppp2ca Gsk3b Cd274 Pdpk1 Os9 Pdcd1 Rnf5 Icoslg Sel1l Magt1 Rbbp4 Rbbp7 Mib2 Pdcd1lg2 Prkab2 Prkab1 Ppp2r5d Pak1 Ppp2r1b Ppp2r1a Pak2 Lyn Yes1 Src Grb2 Fyn Ppp2r5b Ppp2r5a Map3k8 RT1-Db2 Cd3g Ppp2r5e Cd247 RT1-Db1 Cd3e Cd3d Trav19 Map3k14 AC109737.1 Btla Cd4 RT1-Ha Lck RT1-Ba RT1-Bb ENSRNOG00000065955 Trbv16 RT1-Da Grap2 H2ab2 H2ac4 ENSRNOG00000066901 Ctla4 Ccnd1 Kmt2a Kmt2c H2ac18 Csk Csnk2a2 Csnk2a1 Trib3 Hist1h2bq Wdr5 Ash2l Them4 Csnk2b Pik3ca H2aj Rac1 Ptpn6 Pak3 Psma4 Akt3 Psma3 H3-3b Akt2 Akt1 Hist3h2ba Psma6 Pik3r1 Pik3cb Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Pik3r2 Psmd12 Pik3r3 Psmd11 Vav1 Pik3cd Psmd14 Psmd13 Ptpn11 H2bc18 H2az2 Skp1 Rbbp5 H2bc4 Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Pik3r5 Pik3cg Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Cd28 Btrc Icos Psma7 Psmc5 Rictor Psmc2 Cd86 Psmc1 Cd80 Psmc4 Prr5 Psmc3 Mapkap1 Ubb Ubc Nek2l1 Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Prkaa1 Derl3 Psmd2 Prkaa2 Derl2 Mtor Psmd1 Stt3b Adrm1 Rbx1 Cul1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Pik3r6 Tmem258b Tusc3 Cdc42 Cdk4 Cul3 Ezh2 Mlst8 Erlec1 B3gnt3 Dad1 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%10224799 Formation of xylulose-5-phosphate Sord Dcxr Akr1a1 Cryl1 Xylb TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-RNO-8953750.1 Transcriptional Regulation by E2F6 Phc1 Yaf2 Suz12 Eed Phc3 Tfdp2 Tfdp1 L3mbtl2 Ehmt1 Rbbp4 Rbbp7 Pcgf6 Rnf2 Chek1 Pcgf2 Bmi1 Mga Ring1 Cbx3 E2f6 Ezh2 Max Epc1 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222851 Interleukin-17 signaling Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Mapk8 Traf6 Ikbkg Map3k8 Map3k7 Ube2n Uba52 Nfkb1 Fbxw11 Fos Btrc Vrk3 Rps6ka3 Rps6ka1 Rps6ka2 Tnip2 Nod2 Nod1 Map2k7 Map2k6 Ubb Dusp3 Ubc Dusp4 Ripk2 Dusp7 Dusp6 Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Cul1 Map2k3 Mapk1 Tab3 Tab2 Tab1 Chuk Mapk10 Mapk11 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222047 Aspartate and asparagine metabolism Aspg Nat8l Aspa Got2 Naalad2 Folh1 Got1 Slc25a12 Slc25a13 Gadl1 Asns IRON UPTAKE AND TRANSPORT%REACTOME%R-RNO-917937.1 Iron uptake and transport Slc40a1 Hmox2 Abcg2 Hmox1 Fbxl5 Nedd8 Atp6v0b Ireb2 Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Atp6ap1 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Rps27a Atp6v1d Hfe Tf Steap3 Steap4 Mcoln1 Tfrc Tfr2 Skp1 Fth1-ps5 Cp Heph Fth1 Uba52 Ftl1 Ubb Lcn2 Slc46a1 Ubc Slc11a2 Cybrd1 Ftmt Cul1 Aco1 Cand1 Slc22a17 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 96%10225391 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Nfe2l2 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222023 Glycogen synthesis Gys1 Gyg1 Pgm1 Gbe1 Ugp2 Ppp1r3c MYOGENESIS%REACTOME%R-RNO-525793.1 Myogenesis Myog Myod1 Mef2d Boc Ctnna2 Bnip2 Spag9 Mef2a Mef2b Ctnnb1 Mef2c Myf6 Tcf4 Myf5 Tcf3 Ctnna1 Mapk12 Cdh15 Mapk14 Cdh2 Cdon Tcf12 Abl1 Cdc42 Mapk11 XENOBIOTICS%REACTOME DATABASE ID RELEASE 96%10222317 Xenobiotics Ahrr Ahr Cyp2s1 Cyp3a9 Cyp2j16 Cyp3a18 Cyp2w1 Cyp2c66 Cyp2j3 Cyp2c24 Cyp2e1 Cyp2c11 Cyp1a1 Cyp2f2 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a62 Cyp2a2 Cyp3a2 Cyp2a1 Cyp2a3 Arnt2 Arnt TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-RNO-425397.1 Transport of vitamins, nucleosides, and related molecules Slc29a4 Slc25a5 Slc25a4 Slc35b3 Slc33a1 Lcn9 Slc35b2 Slc5a6 Slc35d1 Lcn12 Slc35a1 Slc35c1 Apod Slc27a1 Arl2bp Slc27a4 Slc27a6 Slc35b4 Arl2 Slc35a3 Slc35a2 Slc35d2 Slc28a3 Slc28a2 Slc28a1 Vegp2 Vegp1 Slc29a3 Slc29a2 Slc29a1 MTORC1-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222783 mTORC1-mediated signalling Lamtor2 Rptor RragB Fkbp1a Eif4ebp1 Mtor Rps6kb1 Rheb Slc38a9 Lamtor5 Akt1s1 Lamtor4 Rraga Eef2k Lamtor1 Rragc Rragd Rps6 Eif4e Mlst8 Lamtor3 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-RNO-9730414.1 MITF-M-regulated melanocyte development Lef1 Tnfsf11 Xpo1 Gsk3b Ube2i Crebbp Ctnnb1 Kitlg Qars1 Sin3a Lars1 Rars1 Kars1 Rps6ka1 Myo5a Sox10 Aimp2 Eprs1 Iars1 Tbx3 Mars1 Myrip Sytl2 Dars1 Hdac1 Tcf7 Tcf7l1 Rab27a Tcf7l2 Mark3 Akt3 Mapk3 Csf1 Ep300 Mapk1 Hint1 Mitf Sirt1 Kit Sumo1 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224635 Positive epigenetic regulation of rRNA expression Sf3b1 Hist1h2ai Gsk3b Ddx21 Dek H2ac18 Baz1b Polr1c Myo1c Hist1h2bq Actg1 Kat2a H2aj H2ab2 Tbp Polr1b H3-3b Polr1a Hist3h2ba Polr1f Ep300 H2ac4 Polr1g Polr1e ENSRNOG00000068602 Polr1h Taf1d Mybbp1a Taf1a Taf1c Taf1b H2bc18 Polr2h Kat2b ENSRNOG00000066901 H2az2 Smarca5 Polr2e Polr2f H2bc4 Ercc6 Hist1h4m H2bc1 PLATELET HOMEOSTASIS%REACTOME%R-RNO-418346.1 Platelet homeostasis Slc8a1 Slc8a2 Ppp2cb Ppp2ca Slc8a3 Pde9a Calm3 Ppp2r5d Pde2a Pecam1 Nos1 Prkg2 Pde5a Itpr3 Itpr2 Itpr1 Pde10a Ptpn6 Ppp2r1b Atp2a1 Ppp2r1a Atp2a3 Pde1b Atp2a2 Pde1a Trpc7 Trpc3 Atp2b1 Apob Atp2b4 Atp2b3 Ptpn11 Sri Lrp8 Ppp2r5b Ppp2r5a Pde11a P2rx6 P2rx5 P2rx4 P2rx3 Fgr Ppp2r5e P2rx2 P2rx1 Nos2 Pafah2 Mapk14 P2rx7 Prkg1 Ptgir Nos3 Pla2g4a Irag1 MAPK6 MAPK4 SIGNALING%REACTOME%R-RNO-5687128.1 MAPK6 MAPK4 signaling Prkaca Prkacb Rac1 Pak1 Pak3 Psma4 Pak2 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Kalrn Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Xpo1 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Foxo3 Psmb6l1 Cdc14a Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdk1 Ncoa3 Foxo1 Septin7 Mapk6 Mapk4 Cdc42ep2 Cdc42ep3 Hspb1 Cdc14b Etv4 Cdc42 Dnajb1 Mapkapk5 Ccnd3 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223241 Regulation of TP53 Expression and Degradation Rnf34 Ppp2cb Ppp2ca Phf20 Uba52 Pdpk1 Daxx Sgk1 Rictor Rffl Prr5 Chek2 Usp2 Mapkap1 Ubb Ubc Tp53 Usp7 Ccng1 Ppp2r1b Ppp2r1a Ccna1 Mtor Akt3 Ccna2 Akt2 Akt1 Cdk2 Atm Cdk1 Rps27a Mdm4 Mlst8 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 96%10225069 MET interacts with TNS proteins Hgf Itgb1 Met Tns4 Tns3 LIPOPROTEIN METABOLISM%REACTOME%R-RNO-174824.1 Lipoprotein metabolism Lipa Lipc Bmp1 Zdhhc8 Furin Pcsk5 Prkaca Prkacb Pcsk6 Apoc1 Apoc4 Lipg Pltp Lcat Alb Nceh1 Apobr Npc2 Npc1 Ldlr Mttp Lmf1 Apoc2 A2m Apoa1 Lmf2 Apoa5 Apoc3 Apoa2 Sar1b Rps27a Apoe Apoa4 P4hb Apob Nr1h3 Pcsk9 Nr1h2 Lpl Gpihbp1 Ldlrap1 Soat2 Soat1 Uba52 Scarb1 Vldlr Abca1 Angptl8 Cubn Ubb Ap2m1 Ubc Angptl4 Clta Angptl3 Cltc Mylip Amn Hdlbp Ap2s1 Ap2a2 Ap2a1 Ap2b1 AGGREPHAGY%REACTOME%R-RNO-9646399.1 Aggrephagy Dync1h1 Ube2n Uba52 Dync1i2 Dync1i1 Pcnt Dync1li2 Prkn Dync1li1 Rps27a Arl13b Dynll1 Dynll2 Ubb Park7 Ubc Cftr FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-RNO-9617828.1 FOXO-mediated transcription of cell cycle genes Foxo1 Foxg1 Foxo4 Smad2 Smad3 Smad4 Foxo3 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-RNO-199220.1 Vitamin B5 (pantothenate) metabolism Ppcs Dcakd Ppcdc Coasy Pank4 Aasdhppt Fasn Slc25a16 Slc25a42 Slc5a6 Vnn1 Pank3 Pank2 Pank1 INTERFERON SIGNALING%REACTOME%R-RNO-913531.1 Interferon Signaling Ppp2cb Ppp2ca Nedd4 Prkcd Hspa1b Ube2l6 Hspa1a Ybx1 Ppp2r1b Ppp2r1a Mapk3 Camk2g Tyk2 Camk2d Camk2b Ikbkb Camk2a Ikbkg Ppp2r5a Ube2n Map2k6 Kpnb1 Tp53 Kpna1 Ifng Ifngr2 Ifngr1 Raf1 Jak2 Ptpn1 Irf3 Mavs Rig1 Adar Fnta Usp18 Fntb Pias1 Chuk Ifi44 Ifi44l Uba7 Socs1 Sumo1 Stat3 Furin Stat1 Plcg1 Actg1 Ptpn6 Ifnar1 LOC120103158 LOC120103159 Ifnar2 Ifnb1 Rnasel Ifna4 Ifna1 Ifna1l1 Ifna4l1 Rps27a Irf9 Ptpn11 Sfn Dnajc3 Eif2ak2 Sphk1 Fancl Fancm Pim1 Uba52 Fanca Fancb Fancc Mapt Fance Fancf Fancg Hspa8 Nck1 Gbp5 Pde12 Prkra Ilf2 Actb Dus2 Ilf3 Flnb Tarbp2 Snca Dhx9 Ppm1b Mx2 Arih1 Pggt1b Trim25 Ubb Ptpn2 Hspa1l Ubc Gbp2 Gbp1 Ube2e1 Gbp3 Faap100 Npm1 Casp1 Oasl Hspa2 Faap24 Isg15 Fkbp5 Faap20 Socs3 Cdk1 Becn1 Mapk1 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9929491.1 SPOP-mediated proteasomal degradation of PD-L1(CD274) Ywhag Psmb6 Psmb1 Ccnd1 Psmb3 Psmb2 Uba52 Cd274 Psma7 Psmc5 Psmc2 Psmc1 Csnk2a2 Psmc4 Psmc3 Csnk2a1 Ubb Ubc Psmb6l1 Csnk2b Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Psma6 Spop Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cdk4 Cul3 Psmb5 Psmb4 Psmb7 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-RNO-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) Uba52 Mvb12a Mvb12b Vps37a Vps37b Vps37c Vps37d Vps36 Vps25 Vps28 Tsg101 Ubb Snf8 Ubc Ubap1 Hgs Chmp2b Chmp3 Chmp7 Chmp6 Chmp5 Rps27a Stam2 Vps4a Chmp4c Chmp4bl1 Vps4b Stam Chmp2a PHENYLALANINE AND TYROSINE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222095 Phenylalanine and tyrosine metabolism Hpd Fah Asrgl1 Pcbd1 Qdpr Kyat1 Hgd Tat Pah Il4i1 Gstz1 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 96%10225433 Mitochondrial protein degradation Cox5a Pheta2 Acad8 Cox5b Prkaca Pmpca Ech1 Twnk Shmt2 Ssbp1 Oxsm Mrps2 Htra2 Mt-atp6 Tfam Aldh2 Lonp1 Aldh1b1 Atp5f1c Clpp Iars2 Atp5pd Star Clpx Suclg2 Bdh1 Oxct1 Atp5pf Hmgcs2 Atp5mg Atp5f1b Cs Atp5f1a Atp5po Hspd1 Acot1 Acot2 Fh Acot5 App Acot3 Pdk1 Aco2 Ldhd Pdhb Mrpl32 Uqcrq Idh3a Ndufv1 Ndufv3 Mrps10 Slc25a5 Hadh Ndufs1 Ndufa13 Dbt Eci1 Ndufs3 Glud1 Mrpl12 Uqcrc2 Ogdh Acadsb Pccb Me2 Arg2 Dld Nadk2 Mdh2 Hspa9 Idh2 Mt-co1 Afg3l2 Hsd17b10 Alas1 Acat1 Fech Aldh18a1 Spg7 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME%R-RNO-444473.1 Formyl peptide receptors bind formyl peptides and many other ligands Hebp1 Fpr1 Ccl6 Fpr2l3 Fpr2 App Fpr2l1 Ccl9 Anxa1 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224187 Tandem pore domain potassium channels Kcnk4 Kcnk2 Kcnk1 Kcnk13 Kcnk10 Kcnk16 Kcnk9 Kcnk7 Kcnk18 Kcnk6 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 96%10225457 Regulation of endogenous retroelements Hist1h2ai Cbx5 Znf431l2 Tasor Zfp324 H2ac18 LOC120095871 Setdb1 ENSRNOG00000065205 Trim28 Pphln1 Znf382 Znf624l Zfp719 Zfp867 Hist1h2bq ENSRNOG00000070049 Mphosph8 H2aj Zfp808l3 Atf7ip H2ab2 Zfp758 H3-3b Rex2l4 Hist3h2ba Zfp317 H2ac4 ENSRNOG00000068602 Zfp52 Zfp950l5 Zfp964 Znf354a H2bc18 Morc2 ENSRNOG00000066901 H2az2 LOC102546572 H2bc4 Hist1h4m H2bc1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 96%10225093 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Cbfb Crebbp Runx1 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-RNO-1592389.1 Activation of Matrix Metalloproteinases Mmp16 Mmp17 Mmp8 Furin Try10 Prss2l1 Ctrb1 Mmp10 Plg Klkb1 Ctsk Try5 LOC102554637 Mmp7 Timp1 Mmp2 Mmp3 Timp2 Prss2 Prss3 Mmp9 Elane Mmp1b Tpsb2 Prss1 Spock3 Mmp24 Mmp25 Col18a1 Ctsg ENSRNOG00000069479 Mmp11 Mmp13 Cma1 Mmp14 Mmp15 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10225475 SLC15A4:TASL-dependent IRF5 activation Ikbkg Tasl Chuk Irf5 Ikbkb Slc15a4 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-RNO-202433.1 Generation of second messenger molecules Plcg1 Nck1 Zap70 RT1-Db2 Cd3g Cd247 RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck Itk RT1-Ba RT1-Bb Plcg2 ENSRNOG00000065955 Trbv16 RT1-Da Grap2 Pak1 Pak3 Pak2 Cd101 Fyb1 Lat Lcp2 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 96%10222021 Biological oxidations Tpst1 Mtr Tpst2 Sult2b1 Sult1a1 Sult1c2 Sult1b1 Bpnt2 Sult6b1 Sult4a1 Sult2a2 Bpnt1 Ugt1a2 Ugt1a1 Ugt1a3 Sult2a1 Ugt1a5 Sult2a6 Abhd14b Podxl2 Ugt2b1 Ugt2b7 AC114845.1 Ugt2b34l1 Smox Ugt2b Ugt2b17 Ugt2b37 Arnt2 Ugt2b15 Arnt Ahrr Ahr Ugt1a6 Ugt1a7 Tbxas1 Ugt1a8 Nat1 Nat2 Ptgis Nat3 Ugt2a1 Ptgs1 Ugt2a3 Ces2h Acy1a Ugt3a1 Hsp90ab1 Cyb5b Acss2 Uxs1 Ugp2 Ugdh Cyp39a1 Cyp2s1 Ncoa2 Cyp8b1 Cyp7b1 Nr1h4 Cyp46a1 Cyp27a1 Cyp7a1 Cyp2u1 Aldh1a1 Dpep1 Dpep2 Cyp11a1 Fdx2 Fdxr Cyp26b1 Rxra Cyp26a1 Cyp24a1 Cyp27b1 Adh4 Fdx1 Adh1 Slc35d1 Ptges3 Cyp2j16 Adh7 Cyp4f39 Cyp2j3 Cyp4f1 Cyp4a14 Cyp2f2 Cyp4f3 Cyp4a12 Cyp4f40 Cyp26c1 Cyp4b1 Cyp2a2 Cyp2a1 Cyb5r3 Cyp4f4 Cyp4a10 Cyp4a2 Cyp2a3 Gstz1 Gsta5 Gsta6 Gsta3 Gsta1 Gsta2 Chac1 Chac2 Gstm7 Gstm5 Gstk1 Ggct Gstm1 Gclc Gstm2 Mgst3 Gsto2 Esd Cndp2 Mgst2 Mgst1 Gclm Ggt1 Ggt5 Ggt7 Ggt6 Hpgds Gss Gstp1 Pomc Gstt2 Akr1a1 Gstt1 Oplah Cyp1b1 Cyp4v2 Maoa Cyp21 Cyp11b3 Maob Ces1d Glyatl3 Acsm2 Acsm4 Acsm5 Glyat Cyp2w1 Cyp2c24 Gstm4 Aldh2 Mat1a Aldh1b1 Adh6 Adh5 Cmbl Ephx1 Acy3 Aldh3a1 Fmo1 Aadac Cbr3 Aoc3 Nqo2 Fmo3 Fmo2 Akr7a3 Akr7a2 Cyp11b1 Cyp11b2 Cyp19a1 Abhd10 Acss1 Mtarc2 Bphl Cyp3a9 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a62 Cyp3a2 Aoc1 As3mt Ahcy Comt Mtrr Gsto1 Tpmt Mat2a Sult1e1 Mat2b FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-RNO-2871809.1 FCERI mediated Ca+2 mobilization ENSRNOG00000070986 Plcg1 Calm3 Shc1 Lyn Vav3 Grb2 Vav1 Vav2 Sos1 ENSRNOG00000069193 AABR07065813.1 Lcp2 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Txk Igkvl13 Ppp3ca AABR07065812.2 Ppp3cb Itk ENSRNOG00000063707 Nfatc1 Plcg2 Nfatc3 ENSRNOG00000067679 Nfatc2 ENSRNOG00000070832 Ppp3r1 ENSRNOG00000064041 ENSRNOG00000064481 Grap2 ENSRNOG00000065690 ENSRNOG00000064085 Tec ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Btk Lat SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223789 Sodium-coupled phosphate cotransporters Slc20a2 Slc20a1 Slc34a1 Slc34a3 Slc17a1 Slc34a2 METABOLISM OF VITAMINS AND COFACTORS%REACTOME%R-RNO-196854.1 Metabolism of vitamins and cofactors Mtr Mmachc Slc22a13 Nfs1 Naxd Nmnat3 Nmnat2 Qprt Akr1c18 Mthfd1 Abcc1 Akr1c12l1 Mthfd2 Akr1c19 Folr2 Gphn Pank4 Mocos Akr1c21 Gsto2 Calm3 Shmt2 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Prkg2 Akr1c9 Apoc2 Apoa1 Apoc3 Apoa2 Apoe Apoa4 Apob Lrp1 Sdc4 Cyb5a Sdc3 Sdc2 Lpl Gpihbp1 Lrp8 Lrp2 Lrp10 Plb1 Lrp12 Ttr Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Bco2 Bco1 Gpc6 Clps Pnlip Akr1b10 Rbp4 Apom Rbp2 Rbp1 Sdc1 Lrat Gch1 Idh1 Pdss2 Coq8a Pdss1 Coq8b Coq2 Pts Coq3 Gchfr Coq4 Coq5 Coq6 Hpdl Coq7 Spr Coq9 Stard7 Aco1 Slc25a19 Thtpa Tpk1 Slc19a2 Slc19a3 Akt1 Hsp90aa1 Nampt Shmt1 Ldlrap1 Pdxk Naxe Slc52a2 Ubiad1 Slc52a3 Vkorc1 Lrpl1 Rdh11 Ttpa Mccc1 Vkorc1l1 Btd Mccc2 Acacb Slc25a51 Acaca Aasdhppt Dhfr Fasn Slc19a1 Slc25a42 Slc5a6 Slc5a8 Bst1 Vnn1 Cblif Tcn2 Fpgs Mmut Mthfs Cubn Mthfr Slc25a32 Slc46a1 Pank3 Slc23a1 Pank2 Mthfd1l Pank1 Slc23a2 Ppcs Naprt Dcakd Mmadhc Ppcdc Pcca Coasy Rfk Agrn Pccb Acp5 Aox1 Slc2a1 Slc2a3 Nadk2 Nudt12 Mthfd2l Amn Nmrk1 Mocs3 Slc25a16 Pc Hlcs Nos3 Aldh1l1 Aldh1l2 Cd38 Nadsyn1 Pnpo Nadk Cyb5r3 Nmnat1 Mmaa Mtrr Flad1 Gsto1 Mmab Nt5e Rnls Enpp1 Mocs1 PLASMA LIPOPROTEIN REMODELING%REACTOME%R-RNO-8963899.1 Plasma lipoprotein remodeling Lipc Furin Pcsk5 Pcsk6 Lipg Pltp Lcat Angptl8 Alb Angptl4 Angptl3 Lmf1 Mttp Apoc2 Lmf2 Apoa1 Apoc3 Apoa5 Apoa2 Apoe Apoa4 P4hb Apob Lpl Gpihbp1 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%10223297 CREB phosphorylation Creb1 Rps6ka1 Rps6ka2 Mapkapk2 Atf1 Rps6ka5 Rps6ka3 PROTEIN FOLDING%REACTOME%R-RNO-391251.1 Protein folding Csnk2b Sphk1 Rgs7 Pdcl Tcp1 Cct6b Cct7 Cct6a Gnb2 Gnb1 Gnb4 Cct8 Gnb3 Cct5 Gnb5 Cct4 Csnk2a2 Csnk2a1 Cct3 Cct2 Rgs9 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-RNO-6791226.1 Major pathway of rRNA processing in the nucleolus and cytosol LOC120093247 Heatr1 Nob1 Utp11 Ddx52 Rpl36a Utp18 Wdr43 Rrp7a Noc4l Dis3 Rplp2 Tex10 Riok1 Riok2 AABR07072440.1 Gnl3 Rpl35al8 Ddx49 Wdr36 Rpl22l1 Rplp0 Ddx47 Rplp1 Rpl13a Rpl35al2 Rpl18a Nip7 Rpl13 Rpl14 Rrp36 Rpl15 Mphosph6 Nol9 Rpl17 Rpp14 Rpl18 Rpl19 Nol6 Utp14a Mphosph10 Rpl10 Pes1 Rpl11 Bms1 C1d Rpl12 Rpl10a Exosc9 Exosc8 Exosc5 Krr1 Exosc4 Exosc7 Exosc6 Exosc1 Utp3 Exosc3 Utp4 Rps2 Exosc2 Utp6 Nop58 Nop56 Bop1 LOC134480579 Ebna1bp2 Csnk1d Wdr18 Tsr1 Ddx21 Rpl23a Wdr12 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Las1l Rps27 Ltv1 Rpsa Rpl35 Rps10 Fcf1 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rrp9 Rps8 Rpl6 Rps5 Pwp2 Rpl7 Rps26-ps13 Rpp38 Bysl Fbl Rpl30 LOC134486107 Rpl31 Rpl32 Rpp30 Rpl34 Rpl36al1 Ftsj3 Rpl39l1 Rpl24 Rpl26 Rps3 Imp4 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rpp25 Rps29 Rpl12-ps1 Ubc Rps20 Ncl Rps21 Rpl22 Rps23 Xrn2 Rps24 Rpl23 Snu13 Wdr75 Senp3 Fau Isg20l2 Exosc10 Emg1 Eri1 LOC120097744 Dhx37 Rpl36l5 Rpl36l3 Rpl3l Pdcd11 Pno1 Rpl27a Rpl31l15 Utp20 Nop14 Pelp1 Rcl1 Utp25 Tbl3 Nol11 Rps6 Rpp40 LOC100910714 LOC102551819 Wdr3 Bud23 Dcaf13 Csnk1e Utp15 SIGNAL ATTENUATION%REACTOME%R-RNO-74749.1 Signal attenuation Mapk1 Grb2 Irs2 Shc1 Ins2 Insr Sos1 Irs1 Grb10 Mapk3 Ins1 MRNA CAPPING%REACTOME DATABASE ID RELEASE 96%10222335 mRNA Capping Polr2j Ncbp2 Ncbp1 Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Cdk7 Gtf2h3 Gtf2h5 Ercc2 Ccnh Ercc3 Rngtt Polr2c Rnmt Polr2a Polr2b Mnat1 Polr2g Polr2h Polr2e Polr2f Polr2i NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-RNO-209560.1 NF-kB is activated and signals survival Uba52 Nfkb1 Irak1 Ngf Nfkbia Sqstm1 Rela Rps27a Ngfr Ikbkb Ubb Ubc Traf6 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223759 Golgi Associated Vesicle Biogenesis Ttgn1 Igf2r Ocrl Napa Bloc1s3 Bloc1s4 Bloc1s6 ENSRNOG00000062839 Tpd52 Snapin Arf1 Tbc1d8b Golgb1 Vamp2 Tpd52l1 Tfrc Dnajc6 Dtnbp1 Ap4b1 Fth1-ps5 Pik3c2a Ap1b1 Ap1m2 Vamp7 Bloc1s1 Ap1m1 Vamp8 Fth1 Ap1s3 Ap1s2 Arrb1 Txndc5 Necap1 Ap1g1 Hspa8 Ap4e1 Hip1r Cpd Snx2 Snx9 Picalm Snx5 Pum1 Dnm2 Ftl1 Gak Yipf6 Clta Sort1 Ap3b1 Cltc Sh3d19 Acbd3 Sh3gl2 Rab5c S PHASE%REACTOME DATABASE ID RELEASE 96%10221915 S Phase Gins2 Gins1 Gins4 Gins3 Wapl Esco1 Esco2 Pds5b Pds5a Cdca5 Dna2 Lig1 Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Ccnh Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Smc3 Cdc25b Ccnd1 Stag2 Stag1 Cdk7 Mnat1 Smc1a Psma4 Ccna1 Akt3 Psma3 Akt2 Ccna2 Ube2s Akt1 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Cdc25a Psmd13 Cdc27 Orc4 Cdc26 Orc6 Cdc23 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Gmnn Psmb5 Ptk6 Psmb4 Psmb7 Cdc6 Psmb6 Mcm7 Psmb1 Mcm8 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Cks1b Cables1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Anapc5 Pole4 Anapc4 Rpa1 Anapc1 Rpa2 Anapc2 Wee1 Fzr1 Ubb Rpa3 Anapc7 Ubc Ube2e1 Psmb6l1 Cdkn1b Psmd7 Pole Rb1 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdc16 Cdk4 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-RNO-8951671.1 RUNX3 regulates YAP1-mediated transcription Runx3 Tead2 Tead4 Yap1 Tead3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-RNO-2022854.1 Keratan sulfate biosynthesis Omd Chst1 Chst3 Chst2 B4galt2 B4galt3 Acan Chst6 Ogn St3gal6 St3gal4 St3gal2 St3gal3 St3gal1 Slc35d2 B3gnt7 B3gnt2 Kera B4galt4 B4galt5 B4galt6 Prelp Fmod B3gnt3 B4gat1 Lum SIGNALING BY MST1%REACTOME DATABASE ID RELEASE 96%10224909 Signaling by MST1 Hpn Spint2 Spint1 Mst1 Mst1r SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 96%10223379 Signaling by SCF-KIT Grb7 Stat3 Stat1 Ptpru Grap Kitlg Fer Prkca Sh2b2 Fes Chek1 Grb10 Lck Stat5a Stat5b Grap2 Tec Jak2 Pik3ca Mmp9 Rac1 Ptpn6 Gab2 Lyn Yes1 Src Pik3r1 Cbl Nras Grb2 Pik3r2 Fyn Pik3r3 Kras Vav1 Sos1 Hras Ptpn11 Cma1 Kit DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%10222939 Downregulation of TGF-beta receptor signaling Mtmr4 Uba52 Smad2 Tgfbr1 Smad3 Tgfbr2 Smad7 Strap Stub1 Bambi Rps27a Ubb Ubc Smurf2 Tgfb1 PYROPTOSIS%REACTOME DATABASE ID RELEASE 96%10222541 Pyroptosis Casp1 Gsdme Elane Il1a Chmp2b Gsdmd Il1b Cycsl2 Chmp3 Hmgb1l2 Chmp7 Hmgb1l1 Chmp6 Bax Bak1 Il18 Chmp4c Chmp4bl1 Casp3 Gzmb Cycs Hmgb1-ps34 Chmp2a HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223963 Highly calcium permeable nicotinic acetylcholine receptors Chrna6 Chrna5 Chrnb4 Chrna4 Chrnb3 Chrnb2 Chrna3 Chrna2 Chrna1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-RNO-446219.1 Synthesis of substrates in N-glycan biosythesis Mvd Srd5a3 Dpm2 Dpm1 Dpm3 Gmppa Pmm2 Mpi Pmm1 Nagk Gnpnat1 Amdhd2 Uap1 St8sia6 Gfpt1 St8sia4 Gfpt2 Pgm3 St8sia5 Renbp Npl Neu2 Neu3 Neu4 Neu1 Cmas St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 Dhdds St3gal6 Nudt14 St6galnac2 Alg5 St3gal4 Dolpp1 St3gal5 Fuom St3gal2 Gmds St3gal3 Slc35a1 Dolk Fcsk St3gal1 Dhrsx Nanp St6gal1 Nus1 Glb1 Fpgt St6gal2 Gfus Slc35c1 Nans St8sia2 St8sia3 St8sia1 Ctsa Gne O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME%R-RNO-5173214.1 O-glycosylation of TSR domain-containing proteins Adamts4 Adamtsl3 Adamtsl4 Adamts1 Adamtsl5 Adamts3 Adamts2 Adamts20 Adamts9 Thsd7b Adamts8 Adamts7 Adamts6 Pofut2 Thsd1 Thbs2 Thsd4 Cfp Spon2 Spon1 Sspo B3glct Thbs1 Sema5a Sema5b Adamts13 Adamts14 Adamts15 Adamts16 Adamts17 Adamts18 Adamts19 Adamts10 Sbspon Adamts12 Thsd7a Adamts5 Adamtsl1 Adamtsl2 MEIOSIS%REACTOME%R-RNO-1500620.1 Meiosis Fignl1 Rad51 Dmc1 Firrm AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-RNO-174084.1 Autodegradation of Cdh1 by Cdh1:APC C Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdc16 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225137 SLIT2:ROBO1 increases RHOA activity Myo9b Rhoa ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 96%10222817 Activation of C3 and C5 C2 C4 C3 C5 C4b ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224091 Activation of G protein gated Potassium channels Gng3 Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10222957 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdc16 Cdk1 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-RNO-6807004.1 Negative regulation of MET activity Hgs Hgf Ptpn1 Uba52 Met Lrig1 Cbl Stam2 Rps27a Grb2 Eps15 Sh3gl3 Sh3kbp1 Stam Sh3gl2 Sh3gl1 Ptpn2 Ubb Ubc Usp8 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10223777 Small interfering RNA (siRNA) biogenesis Ago3 Ago2 Ago1 Dicer1 Tarbp2 Tsnax Tsn Prkra Ago4 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-RNO-2243919.1 Crosslinking of collagen fibrils Pxdn Loxl2 Bmp1 Loxl1 Lox Pcolce Tll2 Loxl4 Tll1 Loxl3 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 96%10222353 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Snrpg Ncbp2 Snrpb Ncbp1 Zfp473 Snrpepl2 Lsm10 Lsm11 Slbp Snrpf Snrpd3 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME DATABASE ID RELEASE 96%10222923 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer Tgif1 Ccnc Tgif2 Atp1b4 Uba52 Furin Tfdp2 Tfdp1 Ube2d1 Trim33 Rbl1 Ccnk Men1 Ccnt2 Cdk9 Ube2d3 Ubb Hdac1 Ubc Rnf111 E2f4 E2f5 Parp1 Ppm1a Smad2 Ncor2 Smad3 Smad4 Mapk3 Smad7 Ski Mapk1 Rps27a Wwtr1 Sp1 Usp9x Skil Smurf2 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 96%10223345 G beta:gamma signalling through PI3Kgamma Gng7 Pik3r5 Pik3cg Gng8 Gngt1 Pdpk1 Akt3 Akt2 Gnb2 Akt1 Gnb1 Rhoa Gnb4 Gnb3 Gnb5 Gng11 Gng10-ps1 Pik3r6 Gng3 Gng5 Gng4 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME DATABASE ID RELEASE 96%10224137 Antigen processing-Cross presentation Psme2 Psme1 Psmb9 Psmb10 Psmb8 Cyba RT1-M6-2 Vamp3 Cybb B2m Lnpep RT1-M10-ps1 RT1-M10-ps5 Snap23 Cd207 Mrc2 Mrc1 Psma4 RT1-N3 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 RT1-M1-2 Psmb4 Psmb7 Psmb6 Psmb1 RT1-M1-5 Psmb3 Vamp8 Psmb2 Rt1-ec3 Cd36 Psma7 Ncf1 Ncf2 Ncf4 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 AABR07044308.1 Pdia3 Fcgr1a Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 RT1-M5 RT1-M2 Itgav INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 96%10222523 Inhibition of replication initiation of damaged DNA by RB1 E2F1 Prim2 Prim1 Ppp2cb Rb1 Ppp2r3b Ppp2ca Ppp2r1b Ppp2r1a Pola2 Pola1 INTERLEUKIN-35 SIGNALLING%REACTOME%R-RNO-8984722.1 Interleukin-35 Signalling Il12a Canx Jak2 Tyk2 Stat3 Stat1 Il12rb2 Il6st Ebi3 PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 96%10222667 Peptide chain elongation Eef2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%10222125 tRNA Aminoacylation Ppa1 Ppa2 SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 96%10223447 Synthesis of PC Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc44a2 Pctp Chat Cept1 Chka Chkb Csnk2a2 Phospho1 Csnk2a1 Lpin3 Lpin2 Lpcat1 Mfsd2a Pcyt1b Pcyt1a Abhd3 Pemt Csnk2b Chpt1 Stard10 Stard7 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%10222259 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Mnat1 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Ccnh Taf7l-ps1 Gtf2a1 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Polr2c Taf4 Polr2a Taf2 Polr2b Taf1 Polr2g Gtf2e2 Polr2h Polr2e Polr2f Polr2i BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-RNO-2142700.1 Biosynthesis of Lipoxins (LX) Alox12 Alox5ap Hpgd Alox5 Ltc4s ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-RNO-6803544.1 Ion influx efflux at host-pathogen interface Slc11a1 Atp7a Atox1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-RNO-174154.1 APC C:Cdc20 mediated degradation of Securin Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 UCH PROTEINASES%REACTOME DATABASE ID RELEASE 96%10224803 UCH proteinases Ino80 Uchl3 Uchl5 Ino80e Ino80d Ino80c Ino80b H2ac18 Mbd5 Mbd6 Uchl1 Nedd8 Actg1 Kdm1b Ruvbl1 Psma4 Psma3 Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 H2ac25 Senp8 Psmb5 Psmb4 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Asxl1 Hcfc1 Asxl2 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Mcrs1 Bard1 Ubb Ogt Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Nfrkb Psmd2 Foxk2 Foxk1 Psmd1 Adrm1 H2ac4 Tfpt Bap1 Actl6a Actr5 Yy1 Actr8 CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-RNO-379716.1 Cytosolic tRNA aminoacylation Ppa1 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%10224595 Depolymerization of the Nuclear Lamina Lmna Ccnb1 Lmnb1 Ctdnep1 Cnep1r1 Lpin3 Prkcb Lpin2 Cdk1 Emd Prkca SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 96%10225429 Specification of the neural plate border Tfap2c Tfap2a Tfap2b CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME DATABASE ID RELEASE 96%10222479 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde Camk4 Calm3 Camkk1 Camkk2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-RNO-186763.1 Downstream signal transduction Stat6 Grb7 Stat3 Stat1 Plcg1 Nck1 Rasa1 Pdgfa Pdgfb Stat5a Stat5b Bcar1 Pik3ca Nck2 Crkl Pdgfrb Src Pdgfra Rapgef1 Pik3r1 Pik3cb Nras Grb2 Pik3r2 Kras Sos1 Hras Ptpn11 Crk ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 96%10223571 Enzymatic degradation of dopamine by COMT Maoa Tomt Comt RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10225085 RUNX1 regulates estrogen receptor mediated transcription Cbfb Esr1 Runx1 REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 96%10221991 Regulation of TP53 Activity Zfp385a Ppp2cb Ppp2ca Pdpk1 Ttc5 Pou4f1 Rbbp4 Rbbp7 Pou4f2 Prkab2 Prkab1 Usp2 Cdk5r1 Brpf3 Usp7 Ppp2r1b Ppp2r1a Cdk5 Tp53rkb Tp53rka Blm Wrn Dna2 Mre11 Kat5 Nbn Hus1 Atrip Rffl Chek1 Chek2 Rad9a Rad9b Banp Bard1 Tpx2 Top3a Tp63 Map2k6 Tp53 Rad17 Hdac2 Rfc5 Ccng1 Mapk14 Rfc3 Rfc4 Kmt5a Atm Rfc2 Atr Exo1 Rmi2 Rmi1 Brip1 Mapk11 Tp73 Jmy Rhno1 Dyrk2 Rad50 Ehmt1 Daxx Ing2 Ing5 Csnk2a2 Brd1 Topbp1 Rbbp8 Csnk2a1 Ssrp1 Brca1 Brd7 Rad1 Hdac1 Smyd2 L3mbtl1 Csnk2b Tp53bp2 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Brpf1 Ccna1 Taf12 Akt3 Tbp Akt2 Taf4b Kat6a Ccna2 Akt1 Taf7l-ps1 Ep300 Noc2l Meaf6 Chd3 Taf8 Rps27a Chd4 Taf7 Taf6 Taf5 Hipk1 Taf4 Taf2 Taf1 Mta2 Ppp1r13l Mbd3 Ppp1r13b Plk3 Gatad2a Gatad2b Pml Rnf34 Pip4k2b Uba52 Pip4k2c Phf20 Pip4k2a Sgk1 Aurka Aurkb Rictor Prr5 Rpa1 Rpa2 Mapkap1 Ubb Rpa3 Ubc Prkaa1 Pip4p1 Prmt5 Prkaa2 Mtor Cdk2 Cdk1 Nuak1 Prkag3 Prkag1 Prkag2 Mdm4 Stk11 Mapkapk5 Mlst8 CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-RNO-5607764.1 CLEC7A (Dectin-1) signaling Pdpk1 Prkcd Uba3 Cdc34 Calm3 Ube2d2 Il1b Psma4 Psma3 Psma6 Src Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Ikbkb Skp1 Psmb5 Psmb4 Traf6 Psmb7 Psmb6 Ikbkg Psmb1 Map3k7 Psmb3 Ube2n Psmb2 Relb Uba52 Nfkb2 Nfkb1 Ube2d1 Fbxw11 Btrc Psma7 Rela Psmc5 Ube2m Psmc2 Psmc1 Psmc4 Psmc3 Map3k14 Ppp3ca Ppp3cb Nfatc1 Plcg2 Ubb Nfatc3 Pycard Malt1 Nfatc2 Ubc Ppp3r1 Bcl10 Psmb6l1 Psmd7 Casp8 Clec7a Psmd6 Card9 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Nfkbia Tab3 Tab2 Tab1 Chuk MMR%REACTOME DATABASE ID RELEASE 96%10224651 MMR Pold2 Pold1 Mlh1 Msh6 Pcna Msh2 Pms2 Pold4 Pold3 Exo1 Rpa1 Rpa2 Rpa3 Lig1 PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 96%10224491 Processing and activation of SUMO Sumo3 Senp1 Ube2i Uba2 Senp5 Rwdd2b Senp5l1 Sae1 Sumo2 Senp2 Sumo1 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%10222451 Transport of the SLBP independent Mature mRNA Nup133 Nup210 Ncbp2 Nup155 Ncbp1 Nup153 Nup93 Nup50 Alyref Nxf1 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Eif4e Ranbp2 Nup214 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 96%10224099 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits Gng3 Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10223565 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Wwox Npm1 Tfap2c Esr1 Tfap2a Ube2i Tfap2b Myc Crebbp Kctd1 Dek Kdm5b Atad2 Lhb Tfap2e Cga Ep300 Cited4 Cited1 Cited2 Yeats4 Sumo1 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-RNO-159236.1 Transport of Mature mRNA derived from an Intron-Containing Transcript Nup133 Slu7 Nup210 Nup155 Nup153 Thoc2 Thoc3 Thoc5 Thoc6 Thoc7 Magohb Chtop Poldip3 Casc3 Nxt1 Nxf5 Nxf7 Srsf1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Ncbp2 Ncbp1 U2af1 U2af1l4 Rnps1 Gle1 Fyttd1 Cdc40 Ddx39a Nup93 Nup50 Alyref Nxf1 Nup35 Magoh Ddx39b Nup54 Nup98 Upf3b Sarnp Nup58 Nup37 Pom121 Nup205 Nup107 Dhx38 Sec13 Nup188 Tpr Eif4a3 Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Rbm8a Aaas Srsf11 Ranbp2 Nup214 Srrm1 PHOSPHOLIPID METABOLISM%REACTOME%R-RNO-1483257.1 Phospholipid metabolism Plaat5 Agk Ddhd2 Agpat4 Agpat1 Pcyt2 Tafazzin Cept1 Lclat1 Etnk2 Etnk1 Etnppl Chka Gnpat Chkb Rab14 Selenoi Phospho1 Sacm1l Pi4ka Lpin3 Pi4kb Lpin2 Pik3c2g Tpte2 Mtmr1 Arf3 Arf1 Plb1 Pten Chat Pip5k1b Dgat2l6 Dgat2 Dgat1 Pnpla3 Mtmr14 Pld1 Mtmr3 Stard7 Cds1 Cdipt Pitpnm2 Pitpnm3 Pitpnm1 Hadha Hadhb Agpat2 Alpi Inpp5e Cpne1 Pla2g4f Pla2g2d Cpne3 Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Csnk2a2 Ocrl Inpp5j Pla2g4d Plbd1 Pla2r1 Csnk2a1 Pla2g12a Mboat7 Synj1 Pla2g10 Plaat3 Pld2 Pla2g5 Csnk2b Inpp5d Pik3ca Pip5k1c Pik3r1 Sbf1 Pik3cb Synj2 Pik3r2 Pik3r3 Inppl1 Pik3cd Ptpn13 Ptdss1 Ptdss2 Pla2g15 Inpp5f Pla2g4b Pi4k2b Inpp4a Pikfyve Inpp4b Pik3c2a Pik3c3 Mtm1 Plekha8 Pik3r5 Fig4 Agpat3 Slc44a3 Pik3cg Vac14 Slc44a4 Mtmr12 Slc44a5 Pi4k2a Slc44a1 Pip4k2b Mtmr4 Pip4k2c Pik3r4 Slc44a2 Pip4k2a Rab5a Pctp Rab4a Pip5k1a Awat2 Pnpla2 Lpcat4 Lpgat1 Lpcat1 Pla2g3 Crls1 Mfsd2a Pla2g6 Pcyt1b Pcyt1a Abhd3 Pemt Chpt1 Stard10 Plekha6 Plekha5 Gpd1l Pip4p1 Plekha4 Abhd4 Plekha3 Osbpl10 Plekha2 Miga2 Plekha1 Tnfaip8l2 Miga1 Gpat2 Tnfaip8l3 Gpd1 Tnfaip8l1 Pgp Mboat1 Rufy1 Mboat2 Pitpnb Gpam Gpd2 Osbpl5 Inpp5k Pld6 Pik3c2b Pla1a Bmx Mgll Osbpl8 Pla2g4a Tnfaip8 Cpne6 Mtmr7 Cpne7 Mtmr6 Liph Mtmr9 Lipi Cds2 Pik3r6 Gde1 Acp6 Gpat4 Pnpla6 Gpat3 Enpp6 Lpcat3 Lpcat2 Tmem86b Pnpla8 Plaat1 PROTEIN HYDROXYLATION%REACTOME%R-RNO-9629569.1 Protein hydroxylation Etf1 Rpl8 Ogfod1 Riox1 Kdm8 Rccd1 Jmjd4 Drg1 Zc3h15 Jmjd7 Rpl27a Rps6 Jmjd6 Riox2 Rps23 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-RNO-8876198.1 RAB GEFs exchange GTP for GDP on RABs Rab21 Chml Rab9a Rab9b Dennd2a Rab1A Dennd2c Ric1 Rab10 Rab13 Rab12 Rab14 Rab18 Rab8b Rab8a Rgp1 Ankrd27 Dennd3 Rab3il1 Madd Akt3 Akt2 Akt1 Sbf2 Sbf1 Rab31 Rab35 Rab38 Rab3gap2 Rab3gap1 Dennd1a Rab1b Ulk1 Dennd1b Trappc2l Dennd1c Rin3 Rin1 Rin2 Mon1b Dennd6a Mon1a Dennd6b Rab5a Trappc10 Hps1 Ccz1 Hps4 Trappc12 Trappc11 Trappc13 Rab3a Rinl Gapvd1 Als2cl Gdi1 Rabgef1 Gdi2 Chm Rab7a Rab7b Dennd4c Dennd4a Dennd4b Ywhae Rab27a Rab39a Rab27b Trappc6b Trappc6a Trappc9 Trappc8 Trappc5 Trappc4 Trappc3 Dennd5a Trappc2 Trappc1 Rab6b Rab6a Rab5c Rab5b Dennd5b Als2 Rab3ip INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME%R-RNO-141405.1 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Ube2s Cdc16 Anapc15 Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Anapc7 Cdc20 Ube2e1 HYALURONAN METABOLISM%REACTOME%R-RNO-2142845.1 Hyaluronan metabolism Hyal5 Chp1 Hyal4 Slc17a5 Hyal3 Cemip Hyal1 Gusb Chp1l1 Hyal2 Cd44 Has1 Has2 Has3 Slc9a1 Abcc5 Hexa Hexb PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 96%10222559 Platelet activation, signaling and aggregation Aldoa Pdpk1 Prkcq Rasgrp1 Tln1 Fn1 Pdgfa Pdgfb Alb Ptk2 Mapk3 Apoa1 Grb2 Fyn Rap1a Rap1b Sos1 App Apbb1ip Cd36 Hgf Vcl Bcar1 Ptpn1 Rapgef4 Tuba4a Rapgef3 Mapk14 Rasgrp2 Prkcb Tbxa2r Ppbp Lat Tgfb1 Tgfb2 Tgfb3 Fgb Fga Fgg Pcdh7 Itga2b Plg Csk Egf Serping1 Itgb3 Clu Timp1 Rac1 Akt1 A2m Tf F2 Phactr2 Stxbp2 Stxbp3 Plcg2 Vti1b Chid1 Abcc4 Prkch Prkce Cfd Pf4 A1bg Gp6 Gp5 Rab27b Gp9 Serpine1 Islr Pcyox1l Hrg Mgll Mapk1 Pla2g4a P2ry12 Lhfpl2 Gng10-ps1 Pik3r6 Gas6 Sytl4 Ly6g6f Ahsg Crk Spp2 Stx4 F2rl2 Serpina3n F2rl3 Adra2b Timp3 Fam3c Mpig6b Prkcg Prkcd Dgka Serpinf2 Gnai2 Dgkb Gnai1 Abhd6 Prkca Dgkd Gnai3 Dgke Dgkg Gna11 F13a1 Anxa5 Gna14 Calm3 Qsox1 Gng3 Brpf3 Vegfa Lgals3bp Vegfd Dgkh Gng5 Vegfc Dgki Gng4 Dgkk Vegfb Gnaq Lamp2 Dgkq Gng7 Gng8 Gngt1 Dgkz Itpr3 Gnat3 Itpr2 Itpr1 F2r Wdr1 Lyn Gnb2 Daglb Gnb1 Maged2 Src Rhoa Gnb4 Trpc7 Kng1 Gnb3 Trpc3 Gnb5 Endod1 Gng11 Serpina4 Dagla F8 Actn2 Lcp2 Habp4 Cdc37l1 Serpina1 Arrb2 Arrb1 Tagln2 Adra2a Itih4 Itih3 Adra2c Pros1 Aamp Cd109 Nhlrc2 Fermt3 Lck Lefty2 Thbs1 Manf AABR07021573.2 Lefty1 Igf2 Igf1 Sparc Apoh Raf1 Gtpbp2 Orm1 Ecm1 Rhog Ola1 Rhob Gp1bb Ctsw Rac2 Gp1ba Actn4 Psap Flna Tmsb4x Cd63 Tor4a Clec1b P2ry1 Tmx3 Fcer1g Pdpn Scg3 Selp Cyrib Abhd12 Sccpdh Srgn Pecam1 Actg1 Actn1 Aplp2 Cyb5r1 Mmrn1 Cd9 Pik3ca Plek Shc1 Sod1 Ptpn6 Pik3r1 Pik3cb Vav3 Pik3r2 Pik3r3 Vav1 Vav2 Ptpn11 Pik3r5 Pik3cg Gna13 Syk Cdc42 Ywhaz SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 96%10223607 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ffar4 Dpp4 Gpr119 Lep Gcg Ffar1 Grp CILIUM ASSEMBLY%REACTOME%R-RNO-5617833.1 Cilium Assembly Ywhag Actr1a Dctn1 Dctn2 Prkaca Cc2d2a Tmem67 C2cd3 Rab8a Mark4 Cep162 Rpgrip1l Septin2 Kif24 Ttbk2 Ift140 Tctn3 Fbf1 Tctn1 Kif3a Akap9 Tctn2 Iqcb1 B9d1 Cep89 Mks1 Ahi1 Ift52 Nphp4 Ttc21b Cep83 Ift57 Nphp1 Ift122 Ofd1 Sclt1 Tmem216 Wdr35 Prkar2b Dync2h1 Ppp2r1a Ift172 Wdr19 Arf4 Cep97 Csnk1d Ccp110 Gbf1 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Pcm1 Dynlrb2 Ssna1 Dynlrb1 Ift70b Tubg1 Ift81 Cep63 Dynlt2b Sstr3 Ift80 Cep152 Dynlt5 Tuba4a Dynlt2 Haus4 Haus5 Kif17 Haus6 Pcnt Trip11 Sfi1 Dync2i1 Haus1 Dync2li1 Dync2i2 Cluap1 Traf3ip1 Mkks Ift20 Unc119b Arl13b Cep250 Ift22 Pkd1 Cep290 Cep78 Ift27 Rp2 Cep76 Ift25 Asap1 Cep72 Ift56 Bbs9 Bbs7 Cep164 Cep70 Bbs5 Ift43 Cpap Bbs4 Tubb5 Cct3 Ift46 Plk4 Cct2 Ift74 Odf2 Bbs10 Ift70a2 Bbs12 Alms1 Thoc2l Cetn2 Cngb1 Exoc3 Cep135 Exoc4 Cep43 Exoc5 Cep41 Exoc6 Cep131 Exoc1 Tubb4b Exoc2 Tubb4a Exoc7 Ninl Exoc8 Tcp1 Inpp5e Arl6 Arl3 Cnga4 Cnga2 Bbip1 Cct8 Cct5 Cct4 Bbs2 Atat1 Pde6d Ttc8 Nphp3 Lztfl1 Mchr1 Hsp90aa1 Rab11a Pafah1b1 Dync1h1 Kifap3 Dync1i2 Kif3b Tnpo1 Kif3c B9d2 Nde1 Nek2l1 Rho Clasp1 Ywhae Plk1 Smo Cdk1 Mapre1 Dynll1 Dynll2 Ckap5 Csnk1e Rab3ip DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%10224547 Deactivation of the beta-catenin transactivating complex Sry3 Lef1 Sry Xpo1 Uba52 Ctnnbip1 Apc Ctnnb1 Sox3 Btrc Sox9 Kmt2b Sox7 Sox6 Pygo2 Sox4 Pygo1 Men1 Tle4 Tle3 Tle2 Tle1 Xiap Ubb Hdac1 Ubc Tcf7 Wdr5 Ash2l Sox13 Tcf7l1 Tcf7l2 Akt2 Sox17 Akt1 Bcl9l Bcl9 Cby1 Rps27a Ctbp1 Rbbp5 Chd8 Ywhaz TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME DATABASE ID RELEASE 96%10224901 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Steap3 Bnip3l LOC134478826 Atm RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223021 Retrograde neurotrophin signalling Cltc Dnal4 Ap2a2 Ap2a1 Ap2b1 Ntrk1 Sh3gl2 Ngf Ap2m1 Clta Ap2s1 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%10222729 PKB-mediated events Pde3b ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 96%10223655 Adrenaline signalling through Alpha-2 adrenergic receptor Adra2b Adra2a Adra2c TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-RNO-83936.1 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Arl2bp Slc29a4 Slc28a3 Slc28a2 Slc28a1 Slc25a5 Slc25a4 Arl2 Slc29a3 Slc29a2 Slc29a1 DOPAMINE RECEPTORS%REACTOME%R-RNO-390651.1 Dopamine receptors Drd3 Drd4 Drd5 Drd2 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 96%10223383 Vitamin D (calciferol) metabolism Ldlrap1 Lgmn Sumo3 Pias4 Cyp24a1 Cyp27b1 Ube2i Vdr Cubn Gc Lrp2 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-RNO-1660662.1 Glycosphingolipid metabolism A4galt Cerk M6pr B3galnt1 Ugcg B4galnt1 Ugt8 Gal3st1 B3gnt5 St8sia5 Arsa Smpd2 Neu2 Smpd3 Neu3 Smpd4 Neu4 Smpd1 Neu1 Gba1 Gba3 St6galnac5 Gba2 St6galnac6 Enpp7 Galc Asah2 Asah1 Sts Gm2a St3gal5 Arsl St3gal2 Arsk St3gal3 Arsj Arsi Arsg Gla Sumf1 Glb1 Arsb Sumf2 Ctsa Fut2 Fut1 B3galt4 Glb1l Psap B4galt5 B4galt6 Glb1l3 Glb1l2 Hexa Hexb FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-RNO-75105.1 Fatty acyl-CoA biosynthesis Cbr4 Tecr Acsbg1 Acsbg2 Acaca Hsd17b3 Fasn Hsd17b12 Hacd1 Hacd2 Hacd3 Hacd4 Hsd17b8 Elovl2 Acly Elovl3 Elovl5 Elovl1 Elovl6 Elovl7 Slc27a2 Tecrl Ppt2 Ppt1 Acsf3 Scd1 Morc2 Acsl1 Acsl5 Acsl6 Acsl3 Acsl4 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 96%10223301 Energy dependent regulation of mTOR by LKB1-AMPK Prkab2 Prkab1 Lamtor3 Lamtor2 Rptor RragB Prkaa1 Ppm1a Prkaa2 Mtor Stradb Rheb Cab39 Strada Slc38a9 Lamtor5 Prkag3 Lamtor4 Prkag1 Rraga Prkag2 Tsc2 Lamtor1 Tsc1 Rragc Rragd Stk11 Mlst8 Cab39l GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME%R-RNO-888590.1 GABA synthesis, release, reuptake and degradation Aldh5a1 Rims1 Abat Slc6a1 Syt1 Stx1a Stxbp1 Gad1 Gad2 Hspa8 Snap25 Cplx1 Dnajc5 Vamp2 Rab3a Slc32a1 Slc6a11 Slc6a13 Slc6a12 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 96%10223215 Neuropilin interactions with VEGF and VEGFR Nrp1 Nrp2 Flt1 Kdr GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-RNO-9845576.1 Glycosphingolipid transport GLTP Cptp Esyt1 Cln3 Esyt3 Arf1 Esyt2 Plekha8 PROTEIN UBIQUITINATION%REACTOME%R-RNO-8852135.1 Protein ubiquitination Uchl3 Rnf181 Shprh Rad18 Uba1 Rnf152 Rnf40 Rnf144a Hltf Wac Ube2t Cdc34 Otulin Ube2d3 Ube2d2 Hist1h2bq Usp5 Usp7 Ube2g2 Ube2g1 Ube2s Cdc73 Rps27a Pex2 Ube2c Ube2l3 Ube2r2 Usp9x H2bc4 H2bc1 Pex5 Ube2n Leo1 Uba52 Ube2d1 Ube2w Ube2k Pex14 Ube2v2 Pex13 Ube2b Pex12 Pex10 Ube2a Ubb Prkdc Ubc Bcl10 Ube2e1 Skic8 Pcna Ube2z Rnf20 Ctr9 Paf1 Rraga Uba6 ENSRNOG00000066901 Ube2e3 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 96%10224243 Acyl chain remodelling of PS Osbpl10 Pla2g4f Pla2g2d Mboat1 Pla2g2f Osbpl5 Pla2g2a Pla2g4e Pla1a Pla2g1b Pla2g4a Osbpl8 Pla2g4d Pla2r1 Pla2g12a Pla2g4b Lpcat4 Pla2g10 Plaat3 Pla2g5 Lpcat3 CELL-CELL COMMUNICATION%REACTOME%R-RNO-1500931.1 Cell-Cell communication Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Kirrel1 Kirrel2 Kirrel3 Xiap Skap2 Nphs1 Fyb1 Grb2 Fyn Ctbp1 Tyk2 Il6st Nfkb1 Ctsb Cbll1 Rela Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Vcl Hdac2 Il6 Il6r Furin Tyrobp Itgb1 Nck2 Prkci Rac1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Kdm1a Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Nck1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Pxn Src Pard3 Mogs Nectin1 Angptl4 Cdh9 Nectin2 Pvr Jak2 Cdh8 Nectin4 Cdh7 Cdh6 H2ab2 Cdh3 Cdh2 Twist1 Pard6b Pard6a Kmt5a H2ac4 Sec11c Amot Sec11a Fermt2 Prkcsh Flna Cd47 Flnc Sirt1 Pard6g Vasp Itga6 Zmym2 Cadm3 ENSRNOG00000066901 Sp1 Cdh24 Cadm2 Cadm1 Rnf19b Tesk1 F11r Pomt1 Sdk1 Hace1 Dnttip1 Pomt2 Stat3 Fblim1 Parvb Parva Pcsk7 Pcsk6 Sdk2 Ilk Birc2 H2ac18 Adam19 Afdn Ctbp2 Plec Csnk2a2 Dst Ang2 Ctsl Zeb1 Csnk2a1 Zeb2 Sirpa Cdh18 Cdh17 Cd151 Cdh15 Hist1h2bq Itgb4 Cdh13 Ptk2b Cdh12 Actn1 Hdac1 Cdh11 Cdh10 Ganab Csnk2b Mphosph8 Megf11 H2aj Canx Tiam1 Arhgap32 Spcs3 Spcs1 Spcs2 Farp2 Smarca4 Pip5k1c H3-3b Hist3h2ba ENSRNOG00000068602 Vav2 H2bc18 H2az2 H2bc4 Hist1h4m H2bc1 Arhgef6 Hist1h2ai Arhgef4 Rpn2 Rpn1 Ostc Ost4 Tmem258b Cdc42 Ezh2 Dad1 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-RNO-72202.1 Transport of Mature Transcript to Cytoplasm Nup133 Slu7 Nup210 Nup155 Nup153 Thoc2 Thoc3 Thoc5 Thoc6 Thoc7 Magohb Chtop Poldip3 Casc3 Fip1l1 Nxt1 Nxf5 Nxf7 Srsf1 Srsf9 Srsf7 Sympk Srsf5 Srsf3 Srsf2 Cpsf4 Cpsf1 Ncbp2 Cpsf2 Ncbp1 Cpsf3 U2af1 U2af1l4 Rnps1 Gle1 Fyttd1 Cdc40 Ddx39a Nup93 Nup50 Alyref Nxf1 Slbp Nup35 Magoh Ddx39b Nup54 Nup98 Upf3b Sarnp Nup58 Nup37 Pom121 Nup205 Nup107 Dhx38 Sec13 Nup188 Tpr Eif4a3 Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Eif4e Rbm8a Aaas Srsf11 Ranbp2 Nup214 Srrm1 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-RNO-5663220.1 RHO GTPases Activate Formins Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Dvl1 Mrtfa Dvl2 Dvl3 Ppp2r1b Ppp2r1a Rhoa Ppp2r5b Ppp2r5a Ppp1cc Ppp2r5e Daam1 Evl Srf Rhob Diaph3 Diaph1 Pfn1 Pfn2 Rhoc Scai Fmnl3 Srgap2 Actg1 Rac1 Pafah1b1 Zw10 Knl1 Fmnl2 Fmnl1 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Mad2l1 Nuf2 Cdca8 Incenp Bub1b Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Aurkb B9d2 Actb Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Cdc42 Birc5 Ercc6l Ranbp2 Ckap5 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-RNO-163841.1 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Tpst1 Tpst2 F10 Ggcx Ogfod1 Riox1 Bglap Furin Kdm8 Rccd1 Jmjd4 Drg1 Zc3h15 Jmjd7 Proc Icmt Dhps Riox2 Eif5a Proz Fn3k Fn3krp Eif5a2 Dohh Dph5 Dph6 Eef2 Jmjd6 F2 F8 Etf1 Rpl8 Arsa Sts Pros1 Arsl Arsk Arsj Arsi Arsg Sumf1 Arsb Sumf2 Rps23 Rpl27a F7 F9 Gas6 Rps6 REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225357 Regulation of HMOX1 expression and activity Hm13 Hmox1 STIMULI-SENSING CHANNELS%REACTOME%R-RNO-2672351.1 Stimuli-sensing channels Mcoln2 Clcn6 Clcn7 Ano10 Clcn4 Ttyh3 Clcn5 Ttyh1 Ttyh2 Slc17a3 Trpc4ap Best4 Calm3 Best1 Best3 Best2 Clca1 Clca2 Clca4 Trpc5 Trpc4 Stoml3 Unc80 Scnn1a Scnn1b Unc79 Trpc7 Scnn1g Trpc3 Lrrk1 Rps27a Trpa1 Tpcn1 Bsnd Mcoln1 Sri Trpm2 Trpm1 Wwp1 Nek4 Ano9 Ano8 Uba52 Trpm8 Ryr2 Trpm7 Ryr1 Ano7 Fkbp1b Trpm4 Ano4 Sgk1 Trpm3 Ano3 Trpm6 Ano2 Ano1 Sgk3 Sgk2 Clic2 Trdn Asic5 Asph Asic4 Trpc1 Stom Ubb Ubc Asic1 Asic3 Asic2 Raf1 Ano6 Ano5 Trpv5 Trpv4 Trpv6 Trpv1 Trpv3 Trpv2 Nalcn Clcn2 Tsc22d3 Clcn1 Clcnkb Clcnka Mcoln3 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10224263 Transcriptional activation of mitochondrial biogenesis Idh2 Sirt3 Sirt5 Glud1 Acss2 Cycsl2 Cycs Gabpa Sod2 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME DATABASE ID RELEASE 96%10222779 Inhibition of TSC complex formation by AKT (PKB) Tsc2 Tsc1 Akt3 Akt2 Akt1 BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 96%10225239 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) Ltc4s NUCLEOTIDE CATABOLISM%REACTOME%R-RNO-8956319.1 Nucleotide catabolism Itpa Dnph1 Nudt5 Tymp Upb1 Upp1 Nt5c3a Upp2 Dpys Dpyd Nt5m Samhd1 Pnp Entpd1 Entpd2 Entpd5 Entpd6 Entpd3 Entpd4 Entpd7 Entpd8 Xdh Nudt9 Nudt16 Gda Nudt18 Adprm Nt5c Nt5c1a Nt5c1b Nt5e Nudt1 Nt5c2 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-RNO-9018681.1 Biosynthesis of protectins Cyp1a1 Cyp1a2 Lta4h Alox15 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 96%10222621 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Maob Maoa PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 96%10224973 PTK6 Regulates Cell Cycle Ccne1 Cdkn1b Ccnd1 Cdk4 Cdk2 Ptk6 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-RNO-141430.1 Inactivation of APC C via direct inhibition of the APC C complex Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Ube2s Cdc16 Anapc15 Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Anapc7 Cdc20 Ube2e1 UNWINDING OF DNA%REACTOME%R-RNO-176974.1 Unwinding of DNA Gins2 Gins1 Gins4 Gins3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10223643 Beta-oxidation of very long chain fatty acids Acox1 Ehhadh Abcd1 Eci2 Acot4 Slc27a2 Acaa1b Decr2 Acot8 Mlycd Hsd17b4 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 96%10224489 SUMO is conjugated to E1 (UBA2:SAE1) Uba2 Sae1 Sumo1 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%10225053 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Npm1 Tfap2a SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 96%10222275 SLC-mediated transport of organic anions Slco2b1 Slc25a10 Slc44a3 Slco2a1 Slc13a2 Slc44a4 Slc25a1 Slco4c1 Slc44a5 SLC16A2 Slc44a1 Slco1c1 Slc44a2 Avp Slc17a5 Slc10a6 Slc22a8 Slc22a7 Slc5a8 Slc22a6 Slc5a7 Slc5a12 Emb Slc16a7 Slc25a11 Slc16a3 Slc16a8 Slc16a1 Bsg Slc22a12 Slco3a1 Slc13a5 Slco1a4 Slco4a1 Slc13a3 Slco1b2 CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 96%10221969 Cellular responses to stimuli Suz12 Cox5a Cox5b Eed Gsk3b Hmox1 Rbbp4 Rbbp7 Ube2d3 Ube2d2 Cox4i1 Cox4i2 Ptk2 Mapk3 Mapk9 Ikbkb Mapk7 Mapk8 Ikbkg Cat Nfkb1 Fos Rela Rps6ka3 Rps6ka1 Rps6ka2 Map2k7 Map2k6 Lamtor3 Lamtor2 Vcl Mapkapk3 Mapk14 Jun Mapkapk2 Nfkbia H1-1 H1-0 Map2k3 H1-5 H1-4 H4f3 Chuk Mapk10 Mapk11 Creb3l3 Crebrf Itgav Gpx2 Gpx1 Ncoa2 Atp6v0b Itgb1 Itgb3 Atp6v1g3 Atp6v0e2 Atp6v1c2 Ern1 Atp6v1c1 Terf2 Atp6v0c Acd Terf1 Terf2ip Atp6v1e2 Tinf2 Atp6v1e1 Pot1 Tcirg1 Txnrd1 Atp6v1a Atp6v1b2 Akt3 Atp6v0d2 Akt2 Atp6v0d1 Akt1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Gsr Atp6v1g1 Atp6v1f Ccne1 Atp6v1d Ccne2 Cdkn2b Cdkn2d Ppp2r2a Hspa8 Rpa1 Rpa2 Rpa3 Cdkn1b Ywhae Rptor RragB Mtor Rheb Slc38a9 Lamtor5 Akt1s1 Lamtor4 Rraga Lamtor1 Rragc Rragd Mlst8 Map1lc3b Ep400 Asf1a Cabin1 Hira Ubn1 Hmga2 Hmga1 Anxa2 Gstp1 Map3k5 Tnik Mink1 Map4k4 Camk2g Camk2d Camk2b Camk2a Oma1 Mre11 Eloc Kat5 Elob Nbn Ncf1 Ncf2 Ncf4 Hsph1 Dnajc2 Cryab Hikeshi Hspa14 Hspa13 Rps19bp1 Hsbp1 St13 Hspa12b Hspa12a Bag5 Bag3 Bag2 Bag1 Hspb8 Dnajb6 Hspa9 Atm Hspa4 Sirt1 Clec1b Rad50 Ehmt1 Kdm6b Hspa5 Cyba Cybb Cul2 Sod1 Eif2s3 Med1 Eif2s2 Eif2s1 Trim21 Vhl Dync1h1 Xpo1 Dync1i2 Dync1i1 Ajuba Mbtps1 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Tgs1 Nup188 Dync1li2 Tpr Nup160 Dync1li1 Rae1 Ndc1 Trpv4 Dynll1 Dynll2 Nup85 Mdm4 Nup42 Nup62 Nup43 Nup88 Ly96 Aaas Ranbp2 Nup214 Tlr4 Nup133 Nup210 Nup155 Nup153 Fabp1 Blvrb Hmox2 Pdpk1 Blvra Abcc1 Hsf1 Dnaja1 Hspa1b Sirt3 Hspa1a Alb Arnt Apoa1 P4hb Nploc4 Apob Stip1 Pgrmc2 Eif2ak1 Yme1l1 Dele1 Stoml2 Phb2 Txn Ptpn1 Hsp90ab1 Cycsl2 Ikbke Cycs Sod2 Adm Pkn2 Capn2 Prkci Psma4 Ccna1 Psma3 Capns1 Ccna2 Ube2s Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Eef1a1 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp1 Psmb5 Psmb4 Calcrl Psmb7 Rxra Psmb6 Psmb1 Psmb3 Pgr Psmb2 Uba52 Anapc10 Tbl1x Ube2d1 Anapc16 Btrc Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Hdac3 Fzr1 Ubb Hspa1l Anapc7 Tbl1xr1 Slc46a1 Ubc Foxo3 Ube2e1 Psmb6l1 Psmd7 Rb1 Psmd6 Fkbp4 Hspa2 Psmd8 Fkbp5 Ptges3 Psmd2 Mt-co3 Mt-co2 Ncor2 Psmd1 Adrm1 Carm1 Cul1 Cdk2 Cdc16 Egln1 Egln2 Egln3 Epas1 Mapk1 Nos3 Hif3a Ramp2 Wtip Mt-co1 Limd1 Gng10-ps1 Ar Hif1a Keap1 Actr1a Ppp2ca Ufd1 Dctn1 Mt2 Dctn2 Mt3 Prkaca Prkacb Dctn4 Higd1c Cited2 Gna11 Prkar1a Prkar1b Calm3 Gng3 Mul1 Gng5 Gng4 Gnaq Gng7 Pde4d Gng8 Gngt1 Prkar2a Prkar2b Sesn2 Ppp2r1b Sesn1 Ppp2r1a Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gnas Cox7a1 Cox7a2 Actr10 Cox7a2l Hba1 Hbb P2ry2 Tp53 H2ab2 H2ac4 Ring1 Abl1 ENSRNOG00000066901 Phc2 Nr3c2 Cbx6 Nr3c1 Phc1 Cbx4 Cbx2 Esr1 Phc3 Stat1 Crebbp Ndufa4 Cdk6 H2ac18 Ppara Sin3a Sin3b Bmi1 Prdx2 Prdx5 Hist1h2bq Srxn1 Prdx1 Nfe2l2 H2aj H3-3b Yap1 Hist3h2ba Sqstm1 Ep300 Rnf2 ENSRNOG00000068602 Smarcd3 Cox6a1 Cox6a2 Txn2 H2bc18 Bach1 H2az2 H2bc4 Hist1h4m H2bc1 Cox6c2 Hist1h2ai Cox6b1 Prdx3 Cox6b2 Atf6 Prdx6 Rictor Nprl3 Nprl2 Wdr59 Prr5 Nox4 Mios Depdc5 Wdr24 Erf Mapkap1 Gpx3 Gpx6 Gpx5 Gpx8 Gpx7 Cebpb Fnip1 Fnip2 Samtor Hm13 Hif1an Eif2ak3 Id1 Itfg2 Castor2 Prkaa2 Castor1 Nudt2 Cox8a Ubxn7 Rbx1 Ets1 Cox8c Ets2 Ero1a Szt2 Vcp Atf6b Cox7b Txnrd2 Dnaja2 Cox7c Dnaja4 Kics2 Sod3 Flcn Ccs Sh3bp4 Cdk4 Dnajb1 Cul3 Mapkapk5 Ezh2 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 96%10224427 Scavenging by Class H Receptors Sparc Apob Stab1 DECTIN-2 FAMILY%REACTOME%R-RNO-5621480.1 Dectin-2 family Fyn Clec4e Clec4d Fcer1g Clec6a-ps1 Syk Lyn Plcg2 RAF ACTIVATION%REACTOME DATABASE ID RELEASE 96%10224811 RAF activation Ppp2r5b Ppp2r5a Phb1 Ppp2cb Ppp2ca Ksr1 Araf Ppp1cc Ppp1cb Map2k2 Ppp2r5e Map2k1 Map3k11 Calm3 Ppp2r5d Brap Raf1 Jak2 Braf Ppp2r1b Shoc2 Ppp2r1a Mark3 Mras Src Nras Kras Camk2g Camk2d Hras Camk2b Ywhab Camk2a SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME%R-RNO-480985.1 Synthesis of dolichyl-phosphate-glucose Nudt14 Alg5 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222101 Carnitine synthesis Bbox1 Tmlhe Aldh9a1 Shmt1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-RNO-5654716.1 Downstream signaling of activated FGFR4 Frs2 Plcg1 Frs3 Klb Fgf2 Fgf1 Fgf4 Fgf6 Fgf8 Fgfr4 Fgf9 Fgf16 Fgf17 Pik3ca Shc1 Fgf18 Fgf19 Pik3r1 Nras Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Gab1 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-RNO-195399.1 VEGF binds to VEGFR leading to receptor dimerization Flt1 Flt4 Vegfa Kdr Vegfd Vegfc Pgf Vegfb PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 96%10224979 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Rps27a Uba52 Dok1 Ubb Arap1 Akt1 Ubc Ptk6 Cbl PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-RNO-8964043.1 Plasma lipoprotein clearance Ldlrap1 Lipa Lipc Soat2 Soat1 Uba52 Scarb1 Apoc1 Apoc4 Vldlr Cubn Ubb Nceh1 Ubc Ap2m1 Clta Cltc Apobr Mylip Npc2 Npc1 Ldlr Amn Apoa1 Ap2s1 Hdlbp Rps27a Apoe Apob Ap2a2 Ap2a1 Ap2b1 Nr1h3 Pcsk9 Nr1h2 WAX BIOSYNTHESIS%REACTOME%R-RNO-9640463.1 Wax biosynthesis Awat2 Awat1 Far2 Far1 SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 96%10224369 Signaling by Hippo Dvl2 Nphp4 Tjp2 Mob1a Ywhae Lats1 Mob1b Lats2 Wwc1 Amotl2 Tjp1 Amotl1 Stk4 Yap1 Stk3 Sav1 Amot Casp3 Wwtr1 Ywhab RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-RNO-9954709.1 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Ube2d2 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a LOC134480579 Rpl23a Eloc Elob Ltn1 Cul2 Tcf25 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Rpl4 Rpl5 Rpl3 Psmb5 Rpl35 Psmb4 Psmb7 Rpl36 Psmb6 Rpl37 Rpl38 Psmb1 Rpl39 Psmb3 Rpl8 Psmb2 Rpl9 Uba52 Rpl6 Ube2d1 Rpl7 Psma7 Rpl30 LOC134486107 Rpl31 Rpl32 Psmc5 Psmc2 Rpl34 Psmc1 Rpl36al1 Psmc4 Psmc3 Rpl39l1 Rchy1 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Ubb Rpl12-ps1 Ubc Rpl22 Psmb6l1 Rpl23 Psmd7 Nemf Psmd6 Psmd8 Psmd2 LOC120097744 Psmd1 Adrm1 Rbx1 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Klhdc10 LOC100910714 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223949 Organic anion transport by SLC22 transporters Slc22a7 Slc22a6 Slc22a12 Slc22a8 HYALURONAN DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224391 Hyaluronan degradation Hyal5 Chp1 Hyal4 Slc17a5 Hyal3 Cemip Hyal1 Gusb Chp1l1 Hyal2 Cd44 Slc9a1 Hexa Hexb CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME%R-RNO-419812.1 Calcitonin-like ligand receptors Ramp3 Iapp Calcb Calcr Ramp2 Calca Adm Adm2 Ramp1 Calcrl FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190377.1 FGFR2b ligand binding and activation Fgfbp3 Fgfbp1 Fgf2 Fgf1 Fgf3 Fgf10 Fgf22 Fgf7 Fgfr2 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 96%10224963 Signaling by PTK6 Erbb2 Ccnd1 Erbb3 Ereg Uba52 Stat3 Stap2 Nrg2 Gpnmb Lrrk2 Nrg3 Dok1 Btc Arhgap35 Rasa1 Egf Elmo1 Ubb Elmo2 Arap1 Ubc Pxn Cdkn1b Egfr Bcar1 Ptpn1 Rac1 Sfpq Khdrbs1 Khdrbs3 Hbegf Khdrbs2 Akt1 Cdk2 Socs3 Rhoa Cbl Nras Ccne1 Rps27a Kras Hras Cdk4 Srms Hif1a Crk Ptk6 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-RNO-9754119.1 Drug-mediated inhibition of CDK4 CDK6 activity Ccnd1 Cdk6 Cdk4 Ccnd2 Ccnd3 PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223231 PI3K AKT activation Pik3r2 Irs2 Pik3ca Irs1 Ntrk1 Ngf Pik3r1 Pik3cb Rhoa CD28 DEPENDENT VAV1 PATHWAY%REACTOME%R-RNO-389359.1 CD28 dependent Vav1 pathway Grb2 Cd86 Fyn Cd80 Vav1 Pak1 Rac1 Pak3 Lck Pak2 Cdc42 Cd28 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223849 GP1b-IX-V activation signalling Raf1 Gp5 Gp9 Gp1bb Gp1ba Src Pik3r1 Ywhaz HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%10224527 HDMs demethylate histones Kdm4c Kdm5b Kdm6b Kdm7a Phf2 Kdm4d Phf8 Arid5b Kdm4b Uty Kdm4a Kdm5c Kdm5a Kdm6a H2bc18 Jmjd6 Kdm2b Kdm1b Riox2 Hist1h4m Kdm1a Kdm3b Kdm3a POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223957 Postsynaptic nicotinic acetylcholine receptors Chrnb4 Chrnb3 Chrnb2 Chrnd Chrne Chrna3 Chrng Chrna2 Chrna1 Chrna7 Chrna6 Chrna5 Chrna4 Chrna9 ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 96%10224245 Acyl chain remodelling of PE Plaat5 Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Pla2g12a Lpcat4 Pla2g10 Plaat3 Pla2g5 Pla2g3 Pla2g6 Abhd4 Mboat1 Mboat2 Pla2g4a Pla2g4b Lpcat3 Pnpla8 Plaat1 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 96%10222739 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Mvd Srd5a3 Dpm2 Dpm1 Dpm3 Gmppa Alg9 Pmm2 Mpi Alg8 Alg6 Pmm1 Alg3 Alg2 Alg13 Alg14 Alg12 Mpdu1 Dpagt1 Nagk Gnpnat1 Amdhd2 Uap1 St8sia6 Gfpt1 St8sia4 Gfpt2 Pgm3 St8sia5 Renbp Npl Neu2 Neu3 Neu4 Neu1 Cmas St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 Dhdds St3gal6 Nudt14 St6galnac2 Alg5 St3gal4 Dolpp1 St3gal5 Fuom St3gal2 Gmds St3gal3 Slc35a1 Dolk Fcsk St3gal1 Dhrsx Nanp St6gal1 Nus1 Glb1 Fpgt St6gal2 Gfus Slc35c1 Nans St8sia2 St8sia3 St8sia1 Ctsa Gne METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 96%10223165 Metabolism of steroid hormones Hsd3b Lhb Fdx1 Hsd17b3 Cga Cyp17a1 Hsd3b6 Akr1b10 Hsd3b5 Srd5a3 Hsd11b1 Sts Hsd3b1 Hsd11b2 Srd5a1 Hsd17b12 Srd5a2 Hsd3b5-ps1 Serpina6 Pomc Akr1b1 Stard4 Star Tspoap1 Stard6 Cyp11a1 Tspo Fdx2 Fdxr Cyp21 Cyp11b3 Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Cyp11b1 Cyp11b2 Cyp19a1 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5693567.1 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) Blm Wrn Dna2 Ppp4r2 Pias4 Ube2n Mre11 Ube2i Eme2 Kat5 Eme1 Timeless Nbn Gen1 Hus1 Atrip Sirt6 Rad51c Rad51b Chek1 Ube2v2 Rad9a Rad9b Bard1 Top3a Palb2 Firrm Ppp4c Lig1 Clspn Rad17 Xrcc3 Rfc5 Slx1b Pold2 Xrcc2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Atm Rfc2 Atr Pold4 Tp53bp1 Pold3 Exo1 Mus81 Rmi2 Fignl1 Rmi1 Brip1 Abl1 Brcc3 ENSRNOG00000066901 Herc2 Rnf168 ABRAXAS1 Sumo3 Rnf8 Rhno1 Slx4 Nsd2 Spidr Rad51 Rad50 Rad52 Ercc1 Ercc4 Babam1 Babam2 Topbp1 Rbbp8 Brca2 Brca1 Rad51ap1 Polk Hist1h2bq Uimc1 Rad1 Polh Ccna1 Ccna2 Hist3h2ba Rps27a H2bc4 Hist1h4m H2bc1 Uba52 Pole3 Pole2 Pole4 Rpa1 Rpa2 Ubb Rpa3 Ubc Pole Cdk2 WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 96%10223325 WNT mediated activation of DVL Dvl2 Csnk2b Dvl3 Csnk2a2 Csnk2a1 Pip5k1b Csnk1e Dvl1 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10225443 TGFBR3 regulates activin signaling Tgfbr3 Inha Acvr2a Inhba DOWNREGULATION OF ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224167 Downregulation of ERBB4 signaling Itch Wwp1 Rps27a Uba52 Nedd4 Ubb Src Ubc GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%10224079 Growth hormone receptor signaling Prlr Mapk1 Sh2b1 Jak2 Ptpn1 Lyn Mapk3 Stat5a Ghr Stat5b Gh1 Prl FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 96%10222603 FMO oxidises nucleophiles Fmo1 Fmo3 Fmo2 PTK6 ACTIVATES STAT3%REACTOME%R-RNO-8849474.1 PTK6 Activates STAT3 Stat3 Stap2 Socs3 Ptk6 PLC BETA MEDIATED EVENTS%REACTOME%R-RNO-112043.1 PLC beta mediated events Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Gna11 Camk4 Prkar1a Gna14 Prkar1b Calm3 Grk2 Gnaq Prkar2a Prkar2b Pde1b Pde1c Pde1a Plcb4 Plcb3 Mapk1 Pla2g4a Plcb2 Plcb1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-RNO-1855183.1 Synthesis of IP2, IP, and Ins in the cytosol Ocrl Inpp5j Miox Isyna1 Synj1 Inpp1 Inpp4a Impa2 Inpp4b Impa1 Inpp5a Inpp5b GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 96%10223561 Glycoprotein hormones Fshb Inha Lhb Inhba Cga Inhbb Tshb Inhbc Inhbe IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 96%10222231 IRS-related events triggered by IGF1R Irs2 Pik3r4 Pdpk1 Frs2 Klb Irs1 Trib3 Fgf2 Fgf1 Fgf4 Igf1r Fgf3 Fgf6 Fgf5 Fgf8 Fgfr3 Fgf7 Fgfr4 Fgf9 Fgfr1 Igf2 Fgfr2 Fgf16 Them4 Igf1 Pde3b Tlr9 Fgf17 Pik3ca Fgf18 Fgf19 Gab2 Fgf10 Akt2 Pik3r1 Pik3cb Grb2 Pik3r2 Sos1 Ptpn11 Fgf20 Kl Fgf23 Flt3 Fgf22 Pik3c3 Gab1 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME DATABASE ID RELEASE 96%10225365 Drug-mediated inhibition of MET activation Hgf Met FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-RNO-6809371.1 Formation of the cornified envelope Klk8 Sprr3 Tgm1 Stfa2l3 Casp14 Evpl Spink6 Cela2a Spink5 Perp Klk12 Pkp2 Pkp3 Dsg3 Lipk Dsg4 Dsc2 Rptn Lipm Klk14 Dsc3 Dsp Jup Lipn Dsg1 Dsg2 Klk13 Ppl Pkp1 Dsc1 Cdsn Klk5 Kazn REGULATION OF CDH11 FUNCTION%REACTOME%R-RNO-9762292.1 Regulation of CDH11 function Jup Ctnnd1 Ctnnb1 Cdh11 Amot Adam19 Angptl4 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%10224011 N-glycan trimming in the ER and Calnexin Calreticulin cycle Canx Calr Rad23b Uba52 Vcp Rps27a Psmc1 Ubxn1 Amfr Pdia3 Engase Ngly1 Ubb Ubc REGULATION OF TNFR1 SIGNALING%REACTOME%R-RNO-5357905.1 Regulation of TNFR1 signaling Ikbkg Uba52 Traf2 Ube2d1 Sharpin Tnf Otud1 Tnfrsf1a Birc2 Traf1 Mib2 Spata2 Rnf31 Rack1 Otulin Ube2d3 Usp2 Ube2d2 Clip3 Xiap Sppl2b Ubb Sppl2a Usp4 Ubc Casp8 Tbk1 Mapkapk2 Madd Tax1bp1 Ikbke Tradd Cflar Cyld Optn Stub1 Ripk1 Rps27a Otud7b Fadd Rbck1 Chuk Ube2l3 Ikbkb Ulk1 Usp21 DUAL INCISION IN TC-NER%REACTOME%R-RNO-6782135.1 Dual incision in TC-NER Xab2 Cdk7 Ppie Ercc1 Ercc4 Tcea1 Mnat1 Polk Prpf19 Usp7 Isy1 Rps27a Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Ercc6 Polr2i Polr2j Gtf2h2 Uba52 Gtf2h1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Pole3 Pole2 Pole4 Znf830 Rpa1 Rpa2 Aqr Uvssa Ubb Rpa3 Ubc Pole Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Rfc2 Ccnh Pold4 Pold3 Xpa Ddb1 Cul4a Cul4b MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 96%10222845 MAPK targets Nuclear events mediated by MAP kinases Ppp2cb Ppp2ca Fos Vrk3 Rps6ka3 Rps6ka1 Rps6ka2 Ppp2r5d Dusp3 Dusp4 Dusp7 Creb1 Dusp6 Mapk14 Jun Ppp2r1b Mapkapk2 Ppp2r1a Mapk3 Rps6ka5 Mapk1 Mapk9 Mapk10 Atf2 Mapk11 Atf1 Mapk7 Mapk8 PECAM1 INTERACTIONS%REACTOME%R-RNO-210990.1 PECAM1 interactions Inpp5d Fyn Ptpn11 Ptpn6 Lck Pecam1 Itgb3 Lyn Plcg1 Yes1 Itgav Src G2 PHASE%REACTOME%R-RNO-68911.1 G2 Phase Ccna1 Ccna2 Cdk2 E2f1 E2f3 MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 96%10223307 MDK and PTN in ALK signaling Ptprz1 Alk Mdk Ptn GLYCINE DEGRADATION%REACTOME%R-RNO-6783984.1 Glycine degradation Amt Gcsh Dld AC132020.1 Ogdh Dlst Kgd4 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-RNO-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway Mgat3 RNA POLYMERASE I PROMOTER OPENING%REACTOME%R-RNO-73728.1 RNA Polymerase I Promoter Opening Hist1h2ai H2aj H2ab2 H3-3b Mapk3 Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Mbd2 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m Ubtf H2bc1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 96%10223407 Platelet Adhesion to exposed collagen Fyn Gp6 Fcer1g Lyn SIGNALING BY ERBB2%REACTOME%R-RNO-1227986.1 Signaling by ERBB2 Memo1 Grb7 Erbb2 Erbb3 Ereg Uba52 Ptpn12 Nrg2 Nrg3 Prkcd Btc Prkca Egf Cul5 Ubb Ubc Ptpn18 Usp8 Ptk7 Prkce Egfr Rnf41 Pik3ca Shc1 Akt3 Hbegf Akt2 Akt1 Yes1 Src Pik3r1 Rhoa Hsp90aa1 Stub1 Nras Rps27a Diaph1 Grb2 Fyn Kras Cdc37 Sos1 Hras Ptk6 Gab1 CHYLOMICRON REMODELING%REACTOME%R-RNO-8963901.1 Chylomicron remodeling Apoe Apoa4 Apob Apoc2 Lpl Apoa1 Gpihbp1 Apoc3 Apoa5 Apoa2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-RNO-450531.1 Regulation of mRNA stability by proteins that bind AU-rich elements Zfp36l1 Khsrp Dis3 Prkcd Prkca Hspa1b Zfp36 Hspa1a Psma4 Psma3 Akt1 Psma6 Psma5 Psma2 Psma1 Exosc9 Rps27a Tnfsf13 Exosc8 Psmd12 Exosc5 Psmd11 Exosc4 Psmd14 Exosc7 Psmd13 Exosc6 Exosc1 Exosc3 Exosc2 Pabpc1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Xpo1 Psmb2 Uba52 Psma7 Hspa8 Tnpo1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anp32a Ubb Ubc Dcp1a Psmb6l1 Parn Xrn1 Psmd7 Psmd6 Set Psmd8 Psmd2 Mapkapk2 Psmd1 Adrm1 Elavl1 Hnrnpd Hspb1 Dcp2 Ywhab Nup214 Ywhaz EPH-EPHRIN SIGNALING%REACTOME%R-RNO-2682334.1 EPH-Ephrin signaling Rasa1 Actg1 Sdcbp Efnb1 Arhgef7 Rock2 Efnb2 Rock1 Efnb3 Ephb1 Ephb2 Ephb3 Ephb4 Tiam1 Ephb6 Nck2 Rac1 Pak1 Pak3 Git1 Pak2 Ptk2 Lyn Yes1 Src Rhoa Rlc-a Ngef Vav3 Fyn Vav2 Itsn1 Hras Psenen Psen1 Psen2 Sdc2 Kalrn Ncstn Aph1a Grin1 Aph1b Grin2b Epha2 Arpc3 Arpc2 Actb Arpc5 Arpc4 Mmp2 Efna1 Efna2 Epha1 Epha3 Mmp9 Epha4 Epha5 Epha6 Epha7 Epha10 Efna4 Efna5 Arpc1b Actr2 Arpc1a Actr3 Arhgef28 Cdc42 PROSTANOID LIGAND RECEPTORS%REACTOME%R-RNO-391908.1 Prostanoid ligand receptors Ptgdr2 Ptger2 Ptger3 Ptgdr Ptger1 Ptgdrl Ptgir Ptger4 Ptgfr Tbxa2r SEROTONIN RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223661 Serotonin receptors Htr1d Htr1f Htr4 Htr2a Htr1b Htr2c Htr6 Htr1a Htr2b Htr7 Htr5a RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME DATABASE ID RELEASE 96%10222509 Response of endothelial cells to shear stress Ppp2ca Pdpk1 Stat1 Prkaca Prkacb Gna11 Prkar1a Anxa2 Prkar1b Adm Itgb1 Calm3 Gng3 Itgb3 Gng5 Pkn2 Gng4 Gnaq Gng7 Pde4d Capn2 Gng8 Gngt1 Prkar2a Prkar2b Ppp2r1b Ppp2r1a Ptk2 Capns1 Yap1 Akt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Ikbkb Gnas Calcrl Ikbkg Ppp2r2a Nfkb1 Rela Rictor Prr5 Mapkap1 P2ry2 Vcl Ptpn1 Mtor Ikbke Nfkbia Nos3 Trpv4 Ramp2 Gng10-ps1 Chuk Abl1 Itgav Mlst8 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-RNO-199992.1 trans-Golgi Network Vesicle Budding Ttgn1 Igf2r M6pr Ocrl Napa Bloc1s3 Bloc1s4 Bloc1s6 Hgs ENSRNOG00000062839 Snap23 Tpd52 Snapin Arf1 Tbc1d8b Golgb1 Vamp2 App Tpd52l1 Tfrc Dnajc6 Dtnbp1 Clvs1 Dnase2 Clvs2 Ap4b1 Fth1-ps5 Pik3c2a Ap1b1 Chmp2a Ap1m2 Vamp7 Bloc1s1 Ap1m1 Vamp8 Fth1 Ap4s1 Ap1s3 Ap1s2 Arrb1 Txndc5 Necap1 Ap1g2 Ap1g1 Ap4m1 Hspa8 Ap4e1 Hip1r Cpd Snx2 Gbf1 Snx9 Picalm Snx5 Pum1 Dnm2 Ftl1 Gak Yipf6 Clta Cltb Sort1 Ap3b1 Cltc Sh3d19 Acbd3 Gns Sh3gl2 Rab5c Ctsz Stx4 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME DATABASE ID RELEASE 96%10224603 Asymmetric localization of PCP proteins Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Wnt5a Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Fzd7 Ubb Ubc Dvl2 Psmb6l1 Psmd7 Fzd3 Prickle1 Psmd6 Psmd8 Fzd1 Fzd2 Psmd2 Psma4 Fzd5 Fzd4 Psmd1 Psma3 Adrm1 Pard6a Fzd8 Psma6 Psma5 Psma2 Smurf1 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Smurf2 Psmb7 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%10224061 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation Peli1 Peli2 Ikbkg Peli3 Ube2n Chuk Ikbkb Irak1 Traf6 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-RNO-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases Cradd Pidd1 Casp2 Atm RESOLUTION OF D-LOOP STRUCTURES%REACTOME%R-RNO-5693537.1 Resolution of D-Loop Structures Mre11 Slx4 Eme2 Kat5 Spidr Eme1 Rad51 Rad50 Nbn Gen1 Rad51c Rad51b Rbbp8 Brca2 Brca1 Rad51ap1 Bard1 Top3a Palb2 Firrm Xrcc3 Slx1b Xrcc2 Atm Exo1 Mus81 Rmi2 Fignl1 Rmi1 Blm Brip1 Wrn Dna2 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223835 Organic cation transport Slc25a26 Slc22a3 Slc14a2 Slc67a1 Slc14a1 Slc47a1 Slc22a2 Slc22a5 Slc22a1 Slc22a4 Slc22a15 Runx1 Slc22a16 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-RNO-196836.1 Vitamin C (ascorbate) metabolism Slc23a2 Cyb5r3 Slc2a1 Cyb5a Slc2a3 Gsto1 Slc23a1 Gsto2 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-RNO-74158.1 RNA Polymerase III Transcription Snapc3 Snapc4 Snapc1 Snapc2 Polr3gl Gtf3a Crcp Polr3a Brf2 Polr3d Brf1 Polr1c Polr3e Polr3b Polr3c Polr3f Polr3g Pou2f1 Gtf3c2 Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 Gtf3c5 Bdp1 Tbp Polr2h Polr2e Polr2f REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-RNO-912694.1 Regulation of IFNA IFNB signaling Ptpn1 Stat1 Ptpn6 Ifnar1 LOC120103158 LOC120103159 Ifnar2 Ifnb1 Ifna4 Ifna1 Ifna1l1 Ifna4l1 Usp18 Tyk2 Ptpn11 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223499 Rap1 signalling Rap1gap Raf1 Rapgef4 Rapgef3 Rasgrp2 Prkaca Prkacb Prkg1 Rasgrp1 Rap1a Rap1b Sipa1 Rap1gap2 Ywhab Ywhaz SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 96%10222091 Signaling Pathways Rgs3 Rgs1 Rgs8 Rgs7 Pcp2 Gpsm3 Gpsm2 Gpsm1 Rgs21 Rgs18 Rgs19 Rgs13 Rgs14 Gnat2 Rgs12 Ccr1l1 Wnt11 Gnao1 Nlk Fzd3 S100a9 Prkcb Atp6v0b Trib3 Atp6v0a4 Grb10 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Ptprf Them4 Pde3b Tlr9 Atp6ap1 Insr Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Steap3 Tfrc Stap2 Gpnmb Lrrk2 Dok1 Jag2 Dll1 Dll4 Lbr Gopc Spry1 Cgn Rhoq Pcsk5 Nedd4 Sh3rf1 Rnf111 Snap23 Mkrn1 Rbck1 Wwp1 Ncf1 Ncf2 Ncf4 Vps26a Vps35 Ube2m Vps29 Wnt10a Wnt10b Wls Fzd7 Wnt9a Wnt9b Wnt7a Tmed5 Wnt5b Ror1 Ror2 Wnt6 Wnt2 Wnt4 Wnt2b Wnt16 Rnf41 Prickle1 Lrrc41 Nsmaf Cyba Cybb Cul5 Vhl Rbbp6 Mst1 Mst1r Ptpru Grap Fer Strap Bambi Rhot2 Mfn1 Mfn2 Trak1 Myo19 Trak2 Rpgrip1l Otulin Tulp3 Adcy10 Ift140 Disp2 Scube2 Kif3a Fuz Hhat Mks1 Ift52 Ttc21b Ift57 Mob1a Ift122 Ofd1 Lats1 Mob1b Intu Wdr35 Lats2 Dync2h1 Wwc1 Amotl2 Ift172 Wdr19 Amotl1 Notum Stk4 Stk3 Syvn1 Sav1 Crkl Rapgef1 Ntrk3 Ntf3 Acvr2a Cpsf7 S100a8 Srgap1 Arhgap45 Slk Cavin1 Daam1 Pgrmc2 Tex2 Bcr Arhgap6 Arhgap5 Arhgap4 Sowahc Clip3 Arhgap1 Stom Sppl2b Arap1 Sppl2a Arap3 Alk Arap2 Mdk Ptn Arhgap9 Ptpn18 Arhgap8 Mcam Ptk7 Pld1 Ccdc115 Rtkn Rhpn1 Rhpn2 Stk10 Stard8 Maco1 Ddrgk1 Faf2 Arhgdib Bmpr1a Gmip Bmpr1b Anln Acvrl1 Arhgap10 Amh Iqgap3 Zfyve9 Diaph3 Fam83a Diaph1 Fam83d Arhgap19 Smad9 Arhgap18 Depdc1b Smad5 Smad6 Cit Fam13a Pdgfc Pdgfd Arhgef28 C1qbp Zfyve16 Arhgap22 Acvr1c Arhgap21 Acvr1b Arhgap20 Acvr2b Arhgap26 Gdf2 Arhgap24 Dtx2 Arhgap23 Amhr2 Arhgap29 Grem2 Arhgap28 Cilp Ophn1 Bmpr2 Stbd1 Cer1 Dock2 Thbs4 Def6 Vapb Pcdh7 Myo9b Emc3 Arhgap11a Myo9a Arhgap31 Arhgap30 Prex2 Actc1 Arhgap35 Fmnl3 Tagap Racgap1 Plekhg6 Tmem87a Plekhg3 Bcap31 Ktn1 Farp1 Dlc1 Stard13 Arhgap40 Pkn2 Rock2 Rock1 Pkn1 Arhgap44 Arhgap42 Tjp2 Prkci Elf3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Chd3 Rps27a Chd4 Psmd12 Psmd11 Psmd14 Psmd13 Mta1 Mta2 Mta3 Mbd3 Skp1 Cdc20 Psmb5 Psmb4 Gatad2a Psmb7 Gatad2b Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Ube2d1 Bub1b Btrc Psma7 Nck1 Aurkb Psmc5 Actb Psmc2 Psmc1 Psmc4 Psmc3 Ptpn2 Ubb Ubc Psmb6l1 Cdc14a Psmd7 Psmd6 Psmd8 Plk1 Psmd2 Psmd1 Adrm1 Cul1 Cdk2 Cdk1 Plcb4 Plcb3 Mapk1 Pla2g4a Pdyn Plcb2 Plcb1 Ppp1r1b Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 Ppp1ca Adcy5 Adcy6 Ppp2cb Grb7 Ppp2ca Adcy9 Pde4a Pde4b Prkaca Prkacb Prkcg Prkcd Oprm1 Gnai2 Gnai1 Prkca Gnai3 Gna11 Camk4 Prkar1a Gna14 Fgfrl1 Prkar1b Calm3 Ppp2r5d Flt1 Gng3 Flt4 Grk2 Vegfa Gnal Kdr Pomc Vegfd Gng5 Vegfc Gng4 Pgf Pde4c Vegfb Gnaq Il1rap Gng7 Pde4d Gng8 Gngt1 Irak4 Gnat3 Prkar2a Prkar2b Ppp2r1b Ppp2r1a Cdk5 Pde1b Pde1c Gnb2 Gnb1 Pde1a Gnb4 Gnb3 Gnb5 Gng11 Muc13 Peak1 Cep97 Wdr6 Txnl1 Pak6 Rhov Pak4 Git2 Arhgap12 Epha2 Zfp512b Adra2a Dlg5 Adora2b Adora2a Adra2c P2ry2 Ckap4 Parp1 H2ab2 Ptbp1 H2ac4 Gata3 Ring1 Abl1 ENSRNOG00000066901 Phc2 Cbx6 Ccnd3 Phc1 Cbx4 Cbfb Ccnd1 Cbx2 Esr1 Phc3 Crebbp Kmt2b H2ac18 Csnk2a2 Csnk2a1 Bmi1 Hist1h2bq Prmt1 Hdac1 Wdr5 Ash2l Csnk2b H2aj Smarca4 H3-3b Yap1 Hist3h2ba Ep300 Rnf2 ENSRNOG00000068602 Itch Ptpn11 H2bc18 Runx1 Kat2b H2az2 Rbbp5 H2bc4 Hist1h4m H2bc1 Pml Hist1h2ai Hnrnpa1 Ddx39b Prkaa1 Prkaa2 Derl2 Rbx1 Spop Vcp Hnrnpc Prkag3 Prkag1 Hnrnpf Prkag2 Cdk4 Cul3 Ezh2 Erlec1 Srrm1 Ywhag Suz12 Eed Gsk3b Os9 Hnrnph1 Sel1l Rbbp4 Rbbp7 Mib2 Prkab2 Prkab1 Lpar5 Plppr1 Plppr4 Plppr5 Plppr2 Plppr3 S1pr1 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 Ybx1 Creb1 Spta1 Col4a1 Ptpra Col4a2 Ncam1 Sptb Sptbn1 Sptbn2 Ptk2 Mapk3 Sptan1 Sptbn5 Rps6ka5 Nras Sptbn4 Grb2 Fyn Rbmx Kras Sos1 Hras Tra2b App Atf2 Ikbkb Atf1 Mapk7 Iqgap2 Mapk8 Traf6 Ikbkg Map3k7 Nfkb1 Traf2 Tjp1 Sharpin Tnf Fos Otud1 Vrk3 Tnfrsf1a Traf1 Spata2 Rela Rnf31 Rps6ka3 Rps6ka1 Rps6ka2 Dusp3 Dusp4 Ripk2 Dusp7 Dusp6 Casp8 Mapkapk3 Mapk14 Jun Mapkapk2 Irak1 Nfkbia Tab3 Tab2 Tab1 Chuk Mapk11 Itga8 Itgav Bmp10 Tgfb1 Tgfb2 Tgfb3 Ltbp3 Ltbp2 Furin Ltbp4 Ltk Tnk2 Alkal2 Ltbp1 Alkal1 Ccnk Itgb8 Ccnt2 Itgb6 Itgb1 Bmp2 Itgb3 Kif5a Kif5b Madd Akt3 Akt2 Akt1 Optn Dock5 Dock6 Dock3 Dock4 Tsc2 Dock7 Tsc1 Dock8 Ulk1 Klc1 Klc4 Rab4a Klc3 Klc2 Dock10 Dock11 Sh2b2 Rab7a Prkch Prkce Ywhae Mgll Pik3r6 Als2 Arf6 Rab9a Rab9b Dgka Dgkb Abhd6 Dgkd Dgke Dgkg Itga3 Dgkh Dgki Ckb Dgkk Dgkq Dgkz Itpr3 Itpr2 Itpr1 Pde10a Lyn Daglb Yes1 Src Rhoa Ngef Trpc7 Trpc3 Lrrc7 Camk2g Camk2d Camk2b Dlg1 Dagla Dlg2 Actn2 Dlg3 Dlg4 Camk2a Nefl Grin1 Grin2d Grin2b Tgfbr3 Pde11a Gipc1 Arrb2 Arrb1 Tgfbr1 Tgfbr2 Lhb Cga Zap70 Aamp Lck Thbs1 AABR07021573.2 Igf2 Igf1 Raf1 Jak2 Rhog Rhob Rac2 Ctsd Agt Cma1 Npffr1 Npffr2 Npff Abhd12 Hcrtr2 Hcrtr1 Plat Qrfprl Qrfpr Qrfp Pde2a Hcrt Dkk4 Kremen2 Kremen1 Lrp6 Sost Dkk1 Dkk2 Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Csf2rb Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Pik3r3 Pik3cd Epo Gab1 Pik3r5 Pik3cg Irs2 Epor Fstl1 Fstl3 Chrdl1 Nup98 Nup37 Nup107 Sec13 Nup160 Nup85 Nup43 Aaas Ranbp2 Nup133 Akr1c18 Akr1c12l1 Akr1c19 Akr1c21 Garre1 Shmt2 Akr1c3l1 AABR07032856.1 Akr1c12 Osbpl11 Akr1c1 Nisch Akr1c13 Uaca Nckap1l Wipf3 Wipf1 Itsn2 Akr1c9 Mrtfa Stmn2 Scrib Jag1 Fam83b Fam91a1 Mtmr1 Nox3 Nox1 Samm50 Fam169a Amigo2 Noxa1 Baiap2l2 Baiap2l1 Letm1 Golga3 Gps1 Fgd5 Taok3 P4hb Ralgapa1 Polr2c Chn2 Polr2a Esyt1 Polr2b Trip10 Polr2g Wwp2 Polr2h Fam135a Abi2 Polr2e Abi1 Wdr11 Polr2f Tuba1b Polr2i Msi2 Ppp1r12b Polr2j Stip1 Ppp1r12a Phip Ncbp2 Akap12 Ncbp1 Stk38 Vrk2 Ppp1r14a Abl2 Gtf2f2 Slc1a5 Gtf2f1 Lin7b Cops4 Arpc3 Cops2 Arpc2 Ednrb Ubxn11 Ednra Cpd Sct Arpc5 Rrh Arpc4 Picalm Ptgdr Brk1 Htr4 Ndufs3 Apln Trhr Dsp Tas2r39 Arhgap15 Arhgap17 Htr6 Dsg1 Oprd1 Dsg2 Htr7 Evl Tas2r38 Rhobtb2 C3ar1 Rhobtb1 Crhbp Galr2 Arhgap25 Galr3 Srf Galr1 Arhgap27 Cmklr1 Slitrk5 Slitrk3 Avpr2 Sstr5 Arhgap33 Sstr4 Wasf3 Sstr3 Wasf2 Wasf1 Kel Plekhg1 Sstr2 Ralbp1 Sstr1 Avpr1b Prc1 Rxfp3 Rnf20 Cct6a Avpr1a Cdc42bpa Rxfp1 Cdc42bpb Htr5a Ghrhr Slc4a7 Tbxa2r Arpc1b Gpr183 Actr2 Arpc1a Ppbp Fpr1 Actr3 Btk Gnrh1 Pfn1 Tas1r2 Senp1 Tas1r1 Pfn2 Nmbr Fpr2 Vangl2 Twf1 Ccr10 Tas1r3 Epsti1 C3 Cpne8 Vipr2 Nckap1 Nln Nipsnap2 Vipr1 Ankle2 C5 Cyfip2 Ptgfr Cyfip1 Pnoc Rhoh Tas2r16 Rhof Tas2r13 Rhoc Ppy Rhoj Tas2r135 Rac3 Kif14 Tas2r136 Nmb Rhou Fam13b Oxtr Lpar6 Scai Xcr1 Nckipsd Gpr18 Cct7 Grpr Pak5 Gpr17 Ccdc88a Nms Tmem59 Mtx1 Tas2r140 Nmu Noxo1 Mpp7 Tas2r145 Ankrd26 Cckar Npbwr1 Srgap2 Srgap3 Fshb Ocrl Gpbar1 Tmod3 Nmur2 Cdc42ep1 Gnrhr Adm Cdc42ep4 Nmur1 Plxna1 Ntsr2 Syde1 Ntsr1 Syde2 Tas2r4 Pld2 Ramp1 Elmo2 Rras2 Tas2r3 Dnmbp Brs3 Nsfl1c Ptger4 Ccdc187 Tas2r7 Gabbr1 Plxnd1 Basp1 Ptger2 Ptger3 Ddx4 Spata13 Fshr Kdm4c Gabbr2 Ptger1 Rnd2 Ccr9 Rnd3 Ccr8 Rnd1 Ccr7 Swap70 Arhgdig Ucn2 Mchr1 Baiap2 Kctd13 Ccr6 Ucn3 Fnbp1 Ccr5 Bltp3b Spen Crhr2 Armcx3 Ccr4 Ndufa5 Crhr1 Ccr3 Add3 Gpr132 Tor1aip1 Edn1 Sema4f Edn2 Lmnb1 Edn3 Ptpn13 Cckbr Fmnl2 Fmnl1 Gipr Sh3bp1 Mtnr1b Prag1 Agtr1 Agtr2 Limk1 F2 Vim Gpha2 Hspe1 Gpr37 Tnfaip1 Calcrl Gpr39 Mc1r Gal Taar6 Gpr35 Taar9 Penk Pth1r Taar3 Taar2 Avp Taar5 Rgr Taar1 Npb Gpr143 Grp Opn1mw Pth Kiss1r Gcgr Sctr Ccl19 Ccl17 Gphb5 Nps Mc4r Ccl11 Ccl12 Ptafr Npw Npy Ghrh Ptgdr2 Rho Pth2r Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Gpr4 Gcg Ptgdrl Ccl27 Npsr1 Prok1 Ramp3 P2ry10 Ramp2 Mc3r P2ry13 P2ry12 Ccl20 Gpr55 Ccl21 P2ry14 Adm2 F2rl1 Tas2r40 Fpr2l1 Tas2r41 Cd55 F2rl2 F2rl3 Hcar1 Prokr2 Adra2b Hcar2 Prokr1 Cxcr1 Cxcr2 Cxcr3 Npy1r Xk Gpr65 Gpr68 Cxcr4 Cxcr5 Iapp Oprl1 Adrb2 Adrb1 Adra1b Adrb3 Adra1a Adra1d Lhcgr Uts2 Mc5r Prlh Tacr1 Tacr3 Tacr2 Anxa1 Cxcl11 Nphp4 Hebp1 Calcr Cxcl12 Casr Cxcl10 C5ar2 F2r C5ar1 Ffar3 Aplnr Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng1 Calcb Chrm1 Calca Hrh1 Chrm3 Chrm2 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Gnas Tac3 Tac1 Drd2 Drd3 Drd4 Drd5 Opn4 Opn3 Pmch Ccrl2 Gper1 Oxgr1 Opn5 Sucnr1 Pyy Adora1 Adora3 Rln3 Ltb4r2 Rln1 Cxcl16 Cxcl13 Ucn Tas2r119 Opn1sw Prlhr Oxt Ece1 Ece2 Trh Npy5r Adcyap1 Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Ffar4 Grm8 Ghrl Htr2a Inha Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Inhba Insl3 Inhbb Gip Ptgir Psap Htr1d Htr1f Glp1r Crh Tas2r120 Xcl1 Htr1b Htr1a Kiss1 Adgre5 Adgre1 Pth2 Tshr Glp2r Ccl9 P2ry6 Cxcl9 Ccl7 P2ry4 Ccl6 Ccl5 P2ry1 Ccl4 Ccl3 Ccl1 Cxcl1 Cxcl2 Cxcl3 Pthlh Cxcl5 Uts2b Tas2r105 Tas2r107 Gpr37l1 Ackr3 Ackr4 Trim27 Cck Cnr1 Ackr2 Cnr2 Uts2r Taar8c Sst Oprk1 Vip Tshb Maf1 Mecom Sall4 Rbfox2 Esrp2 Esrp1 Tbp Tial1 Tia1 Spry2 Gtf2a1 Mknk1 Gtf2a2 Memo1 Ier3 Phlpp1 Pip4k2b Pip4k2c Pip4k2a Rps6kb2 Pik3ap1 Foxo6 Cd28 Syk Icos Sgk1 Nr4a1 Ntf4 Pip5k1a Frk Rictor Cd86 Cd80 Prr5 Bdnf Il1rl1 Trat1 Casp9 Mapkap1 Ntrk2 Rgs20 Rgs17 Rgs16 Gnaz Mtr Il17rd Phb1 Erbb2 Erbb3 Ereg Paqr3 Wdr83 Araf Frs2 Prkcq Frs3 Thbs2 Btc Rasgrp4 Rasgrp1 Ranbp9 Tln1 Icmt Rasa2 Rasa1 Rasa4 Rasa3 Fn1 Pdgfa Pdgfb Rce1 ENSRNOG00000067432 Prkg2 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Brap Ret Fgf17 Fgf18 Pea15 Fgf19 Braf Shoc2 Mark3 Fgf10 Hbegf Mras Artn Lypla1 Gfra1 Ralgdsl1 Gfra2 Gfra4 Rap1a Rap1b Tyk2 Bcl2l1 Tgfa Fgf20 Fgf23 Areg Kbtbd7 Fgf22 Kit Il6st Zdhhc9 Ppp2r5b Ppp2r5a Apbb1ip Golga7 Dusp2 Dusp5 Dusp1 Dab2ip Dusp9 Dusp8 Ppp1cc Ppp1cb Kitlg Cnksr2 Map2k2 Ppp2r5e Map2k1 Rapgef2 ENSRNOG00000069024 Map3k11 Klb Irs1 Fgf2 Fgf1 Fgf4 Ppp3ca Fgf3 Ppp3cb Fgf6 Fgf5 Nfatc1 Fgf8 Fgf7 Fgf9 Ppp3r1 Grap2 Lamtor3 Lamtor2 Tec Hgf Egfr Vcl Shc3 Shc2 Pspn Arl2 Abhd17b Abhd17a Il6 Gdnf Pdgfrb Pdgfra Nf1 Il6r Rasgef1a Ralgds Rasgrf1 Rasgrf2 Fnta Abhd17c Fntb Nrtn Lat Kl Flt3 Ppp5c Ywhab Rasal1 Rasal2 Angpt1 Rasal3 Syngap1 Wwox Fgb Fga Ksr1 Fgg Nrg2 Itga2b Nrg3 Spred1 Met Spred3 Spred2 Dusp16 Ptpn7 Ptpn3 Csk Dusp10 Mapk12 Egf Pde6d Pebp1 Tek Aldh1a1 Ccne1 Ptk6 Tfdp2 Tfdp1 Rbl1 E2f4 E2f5 Cdkn1b Rptor RragB Fkbp1a Ppm1a Eif4ebp1 Mtor Stradb Rps6kb1 Rheb Cab39 Strada Pgk1 Slc38a9 Lamtor5 Akt1s1 Lamtor4 Rraga Eef2k Lamtor1 Rragc Rragd Rps6 Stk11 Eif4e Mlst8 Cab39l Pxn Pde5a Pak1 Pak2 Tpm4 Mylk Kat5 Chek1 Kdm4b Cav1 Pafah1b1 Zw10 Knl1 Ska2 Ska1 Zwint Sfn Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Csnk1a1 B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Clip1 Sgo2 Sgo1 Cdc25c Kif2a Kif2b Kif2c Dync1li2 Pmf1 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Ndc80 Ywhaq Ywhah Birc5 Ercc6l Ckap5 Csnk1e Ywhaz Spdl1 Bub1 Itgb3bp Zwilch Pdpk1 Ctnnb1 Sox3 Wnt5a Sox9 Sox7 Sox6 Pygo2 Sox4 Pygo1 Men1 Tle4 Tle3 Tle2 Tle1 Tnks2 Hecw1 Xiap Klhl12 Axin1 Axin2 Rnf43 Tcf7 Dvl1 Dvl2 Dvl3 Sox13 Tcf7l1 Wnt1 Tcf7l2 Fzd1 Fzd2 Fzd5 Fzd4 Fzd6 Sox17 Pag1 Fzd8 Bcl9l Bcl9 Cdc73 Rnf146 Cby1 Znrf3 Ctbp1 Amer1 Tnks Rspo1 Rspo3 Rspo2 Rspo4 Usp34 Tert Chd8 Wnt8b Smurf2 Wnt8a Sry3 Lef1 Dact1 Sry Nab2 Leo1 Dnal4 Ryk Egr2 Ctnnbip1 Apc Lgr5 Lgr6 Frat2 Pip5k1b Frat1 Plxnb1 Cdh1 Ctnna1 Rack1 Eps15 Jup Ctnnd1 Hsp90ab1 Tbk1 Tax1bp1 Ikbke Cyld Ntrk1 Ngf Plcg1 Arhgef7 Nck2 Rac1 Pak3 Git1 Dhrs4 Pdhx Dhrs3 Aldh1a2 Aldh1a3 Nrip1 Hsp90aa1 Cyp26b1 Pdk4 Pdk3 Dhrs9 Ppid Uhmk1 Pdk2 Sdr16c5 Ppidl1 Pdk1 Nr1h3 Nr1h2 Pdhb Kdm1a Rxrb Rxra Cyp26a1 Sphk1 Zdhhc7 Pgr Rxrg Rdh11 Rdh10 Tbl1x Rdh13 Rdh14 Adh4 Pdha1 Adh1 Pdha2 Greb1 Cited1 Strn Prkcz Cav2 Esr2 Abca1 Cdk9 Crabp1 Crabp2 Igf1r Rdh7 Hdac3 Pou2f1 Tbl1xr1 Rara Foxo3 Mmp7 Mmp2 Mmp3 Zdhhc21 Ppard Fkbp4 Mmp9 Fkbp5 Ptges3 Dld Ncor2 Carm1 Aldh8a1 Gps2 Zfp217 Foxa1 Ncoa3 Rarg Nos3 Fabp5 Yy1 Cyp26c1 Dlat Nr5a2 Notch4 Ngfr Mag Mcf2 Srms Omg Arhgdia Rtn4 Ins1 Lman1 Scfd1 Ins2 Arfgap3 Skil Atp1b4 Stx5 Ykt6 Tmed2 Wwtr1 Stat6 Tgif1 Tgif2 Stat3 Stat1 Trim33 Actg1 Fgfbp3 Fgfbp1 Tiam1 Mcf2l Tiam2 Adam17 Bcl2l11 Arhgef15 Arhgef17 Arhgef16 Sqstm1 Arhgef11 Arhgef10 Arhgef12 Ski Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 Psenen Psen1 Psen2 Sos2 Kalrn Ncstn Aph1a Bex3 Arhgef6 Aph1b Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Casp3 Casp2 Plekhg5 Myd88 Plekhg2 Net1 Arhgef10l Ap2m1 Gja1 Clta Cltb Myo6 Cltc Socs3 Cbl Foxo1 Septin7 Mapk6 Mapk4 Cdc42ep2 Cdc42ep3 Hspb1 Cdc14b Etv4 Cdc42 Dnajb1 Mapkapk5 Ube2d3 Ube2d2 Acbd5 Aldh3a2 Ide Emd Mapk13 Usp9x Abcd3 Hdac2 Notch3 Ap2s1 Ap2a2 Ap2a1 Gna12 Ap2b1 Numb Sh3gl2 Ncoa2 Eps15l1 Cd19 Sh3gl3 Sh3kbp1 Sh3gl1 Pik3c3 Mtmr4 Pik3r4 Dbt Itga2 Grk3 Epn1 Crk Kidins220 Galnt3 Vamp3 Dtx4 Rhobtb3 Lama4 Ptprz1 Smpd2 Smpd3 Pde3a Pde7a Grk5 Grk6 Pde8a Pde8b Pard3 Pard6b Pard6a Lrig1 Amot Tns4 Tns3 Fermt2 Hgfac Hpn Rab4b Flna Gga3 Spint2 Spint1 Ranbp10 Sp1 F11r Pcsk6 Birc2 Ctbp2 Dst Actn1 Megf11 Arhgap32 Farp2 Pip5k1c Ccnc Dzip1 Gpr161 Ihh Gli1 Gli3 Gli2 Shh Kif7 Evc Smo Ulk3 Smurf1 Cdon Dhh Spopl Ptch1 Evc2 Hhip Sufu Hmox2 Sfpq Flot2 Khdrbs1 Flot1 Khdrbs3 Khdrbs2 Tradd Cflar Stub1 Ripk1 Tnfsf10 Fas Cdc37 Fadd Faslg Ube2l3 Ptpn12 Gpc5 Nrp1 Nrp2 Shb Sh2d2a Elmo1 Axl Bcar1 Ptpn1 Rapgef4 Rapgef3 Rasgrp2 Adam10 Mmp14 Mmp16 Plg Fes Spp1 Timp1 Timp2 Gast Otud7b Stam Snx3 Ar Hif1a Zranb1 Cftr Foxo4 Il33 Nedd8 Fst Usp2 Usp4 Usp7 Usp8 Hgs Smad1 Smad2 Smad3 Smad4 Smad7 Stam2 Otud3 Usp21 Ccp110 Pten Usp13 Flrt1 Flrt3 Flrt2 Arl13b Cct2 Ptk2b Stat5a Stat5b Pde6g Rgs9 Pde6a Pde6b Gnat1 Rgsl1 Ghsr Rgs4 Rgs5 Rgs2 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME%R-RNO-5685938.1 HDR through Single Strand Annealing (SSA) Rhno1 Mre11 Kat5 Rad51 Rad50 Nbn Rad52 Hus1 Ercc1 Atrip Ercc4 Topbp1 Rbbp8 Rad9a Rpa1 Brca1 Rad9b Rpa2 Bard1 Top3a Rpa3 Rad1 Lig1 Rad17 Rfc5 Rfc3 Rfc4 Rfc2 Atm Atr Exo1 Rmi2 Rmi1 Blm Brip1 Wrn Abl1 Dna2 VISUAL PHOTOTRANSDUCTION%REACTOME%R-RNO-2187338.1 Visual phototransduction Akr1c18 Akr1c12l1 Akr1c19 Akr1c21 Calm3 Nmt1 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Akr1c9 Gngt1 Dhrs3 Apoc2 Apoa1 Gnb1 Apoc3 Apoa2 Apoe Gnb5 Apoa4 Apob Lrp1 Sdc4 Sdc3 Rgs9bp Sdc2 Ppef1 Lpl Pde6g Gpihbp1 Rgs9 Lrp8 Lrp2 Grk1 Lrp10 Grk4 Plb1 Nmt2 Metap1 Lrp12 Metap2 Ttr Camkmt Gpc1 Gucy2e Rdh11 Gpc3 Sag Rdh10 Gpc2 Gucy2f Gpc5 Cnga1 Gpc4 Bco2 Pde6a Bco1 Pde6b Rdh12 Gpc6 Gnat1 Cyp4v2 Clps Rcvrn Stra6 Pnlip Guca1b Rpe65 Akr1b10 Guca1a Rbp4 Rbp3 Myo7a Opn1mw Apom Rbp2 Rlbp1 Rbp1 Sdc1 Lrat Awat2 Opn1sw Rho Agrn Fnta Fntb Cngb1 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%10224783 SHC-mediated cascade:FGFR3 Fgf16 Fgf17 Shc1 Fgf18 Nras Grb2 Kras Sos1 Hras Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Fgf9 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-RNO-9033500.1 TYSND1 cleaves peroxisomal proteins Tysnd1 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 96%10222789 Transfer of LPS from LBP carrier to CD14 Lbp Cd14 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%10225385 Regulation of Expression and Function of Type II Classical Cadherins Zeb2 Jup Ctnnd1 Ctnnb1 Sp1 Cdh11 Amot Adam19 Angptl4 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%10224993 MET activates PI3K AKT signaling Hgf Grb2 Pik3ca Met Pik3r1 Gab1 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-RNO-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex Bcl11b Smarcc1 Phf10 Smarca4 Arid1a Actl6a Smarcd1 Ss18 Smarce1 Smarcd3 Smarcd2 Dpf2 Actg1 Bcl7a Smarcb1 Bcl7b Bcl7c Bcl11a POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%10223779 Post-transcriptional silencing by small RNAs Ago3 Ago2 Ago1 Tnrc6c Tnrc6a Tnrc6b Ago4 RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225171 RHOG GTPase cycle Lman1 Ophn1 Stbd1 Dock2 Vapb Arfgap3 Arhgap35 Mpp7 Vamp3 Cdc42ep1 Plekhg3 Garre1 Itgb1 Shmt2 Ktn1 Elmo2 Arhgap32 Mcf2l Cav1 Arhgdig Pak2 Arhgef16 Pik3r1 Emd Letm1 Ndufa5 Vav3 Dock5 Vav1 Vav2 Dock3 Itsn1 Dock4 Arhgef26 Esyt1 Tfrc Kalrn Hspe1 Iqgap2 Arhgef5 Pak4 Vrk2 Epha2 Stx5 Ykt6 Pgrmc2 Prex1 Map3k11 Ndufs3 Trio Arhgap5 Arhgap1 Dsg2 Rab7a Mcam Pld1 Rhog Arhgdib Diaph3 Depdc1b Lamtor1 Lbr Cdc42 Arhgap21 Mcf2 Ankle2 Arhgdia Cyfip1 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-RNO-8853383.1 Lysosomal oligosaccharide catabolism Man2b1 Man2c1 Manba SYNTHESIS OF CL%REACTOME DATABASE ID RELEASE 96%10224253 Synthesis of CL Crls1 HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%10224575 HDACs deacetylate histones Hist1h2ai Hmg20b Tbl1x Sap18 Rbbp4 Rbbp7 H2ac18 Suds3 Hdac3 Hist1h2bq Tbl1xr1 Hdac1 Rcor1 Brms1 Hdac2 Ncor2 Hdac10 Hist3h2ba Gps2 Hdac8 Sap30l H2ac4 ENSRNOG00000068602 Chd3 Chd4 H2ac25 Mta1 H2bc18 Mta2 Arid4b Mta3 Arid4a ENSRNOG00000066901 Mbd3 Rest H2bc4 Hist1h4m Kdm1a H2bc1 Gatad2a Gatad2b REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 96%10223731 Reduction of cytosolic Ca++ levels Slc8a1 Slc8a2 Slc8a3 Atp2b1 Atp2b4 Atp2b3 Calm3 Atp2a1 Atp2a3 Atp2a2 Sri SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 96%10223305 Signaling by BMP Bmpr2 Cer1 Tgfbr3 Ube2d1 Fstl1 Chrdl1 Bmp2 Ube2d3 Inha Smad1 Smad4 Smad7 Bmpr1a Inhba Bmpr1b Acvrl1 Amh Smurf1 Ski Smad9 Smad5 Smad6 Zfyve16 Acvr2b Gdf2 Acvr2a Bmp10 Amhr2 Smurf2 Grem2 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 96%10223709 Adrenaline,noradrenaline inhibits insulin secretion Gng7 Adcy5 Gng8 Adcy6 Gngt1 Adra2a Gnb2 Adra2c Gnb1 Gnai2 Gnai1 Gnb4 Gnb3 Gnb5 Gng11 Gng10-ps1 Gng3 Gng5 Gng4 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%10224703 BBSome-mediated cargo-targeting to cilium Sstr3 Tcp1 Arl6 Mchr1 Smo Bbip1 Cct8 Mkks Cct5 Cct4 Bbs2 Ttc8 Lztfl1 Bbs9 Bbs7 Bbs5 Bbs4 Cct3 Cct2 Bbs10 Bbs12 Rab3ip ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10222843 Activation of the AP-1 family of transcription factors Mapk1 Mapk14 Jun Mapk9 Mapk10 Atf2 Mapk11 Fos Mapk3 Mapk8 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 96%10222915 Signaling by TGFB family members Cgn Men1 Nedd8 Fst Ube2d3 Rnf111 Smad1 Smad2 Smad3 Smad4 Mapk3 Smad7 Rhoa Stub1 Usp9x Acvr2a Skil Smurf2 Atp1b4 Tgfbr3 Gipc1 Arrb2 Arrb1 Tgfbr1 Tgfbr2 Ube2m Fgf2 Pard3 Parp1 Inha Pard6a Bmpr1a Inhba Bmpr1b Inhbb Acvrl1 Amh Zfyve9 Smad9 Smad5 Smad6 Wwtr1 Zfyve16 Acvr1c Sp1 Acvr1b Itga8 Acvr2b Gdf2 Itgav Bmp10 Mmp14 Amhr2 Tgfb1 Grem2 Tgfb2 F11r Tgif1 Tgfb3 Tgif2 Mmp16 Bmpr2 Cer1 Ltbp3 Ltbp2 Furin Ltbp4 Ltbp1 Trim33 Ccnk Itgb8 Ccnt2 Itgb6 Itgb1 Bmp2 Itgb3 Hdac1 Timp1 Timp2 Ski Rps27a Psenen Psen1 Psen2 Ncstn Aph1a Ccnc Aph1b Mtmr4 Uba52 Tfdp2 Tfdp1 Ube2d1 Rbl1 Strap Bambi Fstl1 Fstl3 Prkcz Chrdl1 Cdk9 Ubb Ubc E2f4 E2f5 Fkbp1a Ppm1a Ncor2 Smurf1 Cbl Mapk1 GABA SYNTHESIS%REACTOME%R-RNO-888568.1 GABA synthesis Gad1 Gad2 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 96%10222319 Cytochrome P450 - arranged by substrate type Cyp39a1 Cyp2s1 Ncoa2 Cyp8b1 Cyp7b1 Nr1h4 Cyp2w1 Cyp46a1 Cyp27a1 Cyp2c24 Cyp7a1 Cyp2u1 Pomc Arnt2 Arnt Ahrr Ahr Cyp11a1 Fdx2 Fdxr Cyp26b1 Cyp11b1 Cyp11b2 Cyp19a1 Rxra Cyp26a1 Cyp24a1 Cyp3a9 Cyp27b1 Cyp1b1 Fdx1 Cyp3a18 Cyp4v2 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Tbxas1 Cyp3a1 Cyp1a2 Cyp2d4 Ptgis Cyp3a62 Cyp3a2 Cyp2j16 Adh7 Cyp4f39 Cyp21 Cyp2j3 Cyp11b3 Cyp4f1 Cyp4a14 Cyp2f2 Cyp4f3 Cyp4a12 Cyp4f40 Cyp26c1 Cyp4b1 Cyp2a2 Cyp2a1 Cyp4f4 Cyp4a10 Cyp4a2 Cyp2a3 RAC2 GTPASE CYCLE%REACTOME%R-RNO-9013404.1 RAC2 GTPase cycle Lman1 Ophn1 Stbd1 Dock2 Def6 Vapb Mtx1 Arhgap35 Mpp7 Cyba Vamp3 Cybb Racgap1 Cdc42ep1 Garre1 Cdc42ep4 Itgb1 Syde1 Pld2 Nckap1l Arhgap42 Pik3ca Tiam1 Arhgap32 Pak1 Cav1 Swap70 Git1 Samm50 Pak2 Pik3r1 Emd Baiap2l1 Armcx3 Vav3 Pik3r2 Pik3r3 Vav1 Taok3 Vav2 Dock3 Dock4 Esyt1 Tfrc Abi2 Abi1 Pak4 Vrk2 Git2 Epha2 Ncf1 Abr Dock10 Ncf2 Ncf4 Pgrmc2 Brk1 Prex1 Bcr Trio Arhgap17 Arhgap1 Dsg2 Rab7a Mcam Slitrk5 Wasf2 Rac2 Diaph3 Depdc1b Lamtor1 Lbr Cdc42 Arhgap21 Nckap1 Mcf2 Arhgap26 Ankle2 Arhgdia Cyfip1 SYNTHESIS OF KETONE BODIES%REACTOME%R-RNO-77111.1 Synthesis of Ketone Bodies Hmgcl Acss3 Bdh2 Bdh1 Hmgcll1 Acat1 Hmgcs2 Aacs THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-RNO-428930.1 Thromboxane signalling through TP receptor Gng7 Gng8 Gngt1 Gna13 Gnb2 Gnb1 Tbxa2r Gnb4 Gnb3 Gna11 Gnb5 Gng11 Aamp Gna14 Gng10-ps1 Gng3 Gng5 Gng4 Gnaq SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 96%10222547 SMAC (DIABLO) binds to IAPs Casp7 Diablol1 Xiap REGULATION OF PYRUVATE METABOLISM%REACTOME%R-RNO-9861718.1 Regulation of pyruvate metabolism Pdp1 Pdpr Pdp2 Uba52 Pkml1 Pdha1 Pdha2 Ranbp9 Wdr26 Nek1 Ubb Mkln1 Ubc Gid4 Maea Ldha Armc8 Me1 Rmnd5b Dld Pdhx Pgam5 Rps27a Pdk4 Pdk3 Dlat Pdk2 Pdk1 Pdhb Gstz1 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 96%10222111 Cellular response to chemical stress Keap1 Cox5a Cox5b Fabp1 Ufd1 Blvrb Gsk3b Map1lc3b Hmox2 Blvra Abcc1 Hmox1 Higd1c Mul1 Alb Gstp1 Cox4i1 Cox4i2 Sesn2 Sesn1 Nploc4 P4hb Cox7a1 Cox7a2 Cat Cox7a2l Ncf1 Hba1 Ncf2 Hbb Ncf4 Txn Cycsl2 Cycs Gpx2 Sod2 Gpx1 Ncoa2 Crebbp Ndufa4 Ppara Cyba Sin3a Cybb Sin3b Prdx2 Prdx5 Srxn1 Prdx1 Nfe2l2 Sod1 Prkci Txnrd1 Psma4 Akt3 Psma3 Akt2 Sqstm1 Akt1 Psma6 Ep300 Psma5 Psma2 Gsr Psma1 Rps27a Psmd12 Psmd11 Smarcd3 Cox6a1 Psmd14 Cox6a2 Psmd13 Txn2 Bach1 Med1 Skp1 Psmb5 Psmb4 Rxra Cox6c2 Psmb7 Trim21 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Tbl1x Btrc Psma7 Cox6b1 Prdx3 Cox6b2 Psmc5 Prdx6 Psmc2 Psmc1 Psmc4 Psmc3 Nox4 Hdac3 Gpx3 Ubb Gpx6 Tbl1xr1 Gpx5 Ubc Gpx8 Gpx7 Psmb6l1 Psmd7 Hm13 Psmd6 Psmd8 Mt-co3 Psmd2 Prkaa2 Mt-co2 Ncor2 Nudt2 Psmd1 Cox8a Carm1 Ubxn7 Adrm1 Rbx1 Cul1 Tgs1 Cox8c Ero1a Vcp Cox7b Txnrd2 Cox7c Mt-co1 Sod3 Ccs Cul3 MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10223125 Membrane Trafficking Ereg Btc Galnt1 Galnt2 Spta1 Sptb Sptbn1 Sptbn2 Hbegf Sptan1 Sptbn5 Sptbn4 Grb2 Vamp2 App Tgfa Areg Tjp1 Il7r Egfr Chmp2b Chmp3 Kif4b Chmp7 Ap2s1 Chmp6 Kif4a Vps4a Chmp4c Dnm3 Ap2a2 Chmp4bl1 Ap2a1 Ap2b1 Sh3gl2 Alpi Cyth2 Cyth3 Cyth4 Vps36 Cyth1 Slc18a3 Bnip1 Egf Vps25 Vps28 Bin1 Synj1 Bloc1s3 Kif18b Bloc1s4 Kif19 Bloc1s6 Kif26b Snf8 Kifc1 Snap29 Kifc2 Snx18 Kif26a Ubap1 Ston1 Ston2 Eps15l1 Kif11 ENSRNOG00000062839 Kif12 Tor1a Tor1b Kif15 Nbas Rab36 Kif5a Kif5b Rab3il1 Tpd52 Kif21a Madd Scarb2 Kif1c Akt3 Ldlr Akt2 Snapin Kif21b Akt1 Kif13b Cops3 Kif1a Sbf2 Cops6 Kif1b Sbf1 Optn Cops8 Kif6 Rab11b Aak1 Rab11a Synj2 Rab31 Tbc1d8b Rab35 Syt11 Tf Kif9 Rab38 Sh3gl3 Tsc2 Sh3kbp1 Tsc1 Tfrc Rab3gap2 Tpd52l1 Rab3gap1 Vps4b Dennd1a Dtnbp1 Kif22 Dnajc6 Clvs1 Rab1b Sh3gl1 Kif23 Dnase2 Fnbp1l Ulk1 Clvs2 Dennd1b Rint1 Kif28 Trappc2l Pik3c2a Fth1-ps5 Kif27 Ap4b1 Dennd1c Bicd2 Ap1b1 Kif16b Chmp2a Bicd1 Rin3 Kif20a Gabarap Klc1 Ap1m2 Agpat3 Vamp7 Fcho1 Rin1 Kif20b Bloc1s1 Fcho2 Rin2 Ap1m1 Pafah1b3 Mon1b Kifap3 Vamp8 Pafah1b2 Dennd6a Ap4s1 Fth1 Mon1a Ap1s3 Klc4 Mvb12a Dennd6b Ap1s2 Rab5a Mvb12b Rab4a Klc3 Necap2 Txndc5 Trappc10 Klc2 Necap1 Ap1g2 Vps37a Ap1g1 Rabgap1 Rab33b Vps37b Ap4m1 Rab33a Vps37c Kif3b Hspa8 Tbc1d2 Vps37d Ap4e1 Hps1 Hip1r Tbc1d7 Agfg1 Kif3c Gabarapl2 Vps45 Snx2 Snx9 Ccz1 Hps4 Snx5 Trappc12 Pum1 Trappc11 Cops7a Trappc13 Cops7b Rab3a Hip1 Rinl Tsg101 Gapvd1 Ftl1 Als2cl Gak Gdi1 Stx18 Rabgef1 Yipf6 Gdi2 Chm Pla2g6 Rab7a Pacsin1 Rab7b Pacsin3 Pacsin2 Dennd4c Sort1 Dennd4a Ap3b1 Dennd4b Sh3d19 Ywhae Rab27a Grk3 Rab39a Amph Tbc1d14 Snap91 Rab27b Syt2 Tbc1d13 Syt9 Tbc1d16 Acbd3 Tbc1d15 Syt8 Tbc1d17 Use1 Trappc6b Akp3 Trappc6a Alpp Trappc9 Alpg Trappc8 Ubqln2 Tbc1d10c Chmp5 Trappc5 Ubqln1 Trappc4 Epn2 Trappc3 Epn1 Dennd5a Reps1 Trappc2 Reps2 Tbc1d10b Trappc1 Rab6b Tbc1d10a Rab6a Rab5c Rab5b Dennd5b Stx4 Als2 Golga4 Rab3ip Sytl1 Rab43 Tbc1d25 Tmf1 Tbc1d24 Sys1 Arf6 Golga1 Map1lc3b Vps51 Rab21 Vps52 Chml Vps54 Arl1 Rab9a Gcc2 Rab9b Gcc1 Dennd2a Rab1A Usp6nl Stx6 Dennd2c Ric1 Ttgn1 Rab10 Igf2r Scoc Rab13 M6pr Rab12 Vti1a Rab14 Vamp3 Rab18 Vamp4 Rab8b Stx16 Rab8a Arfip2 Rgp1 Rhobtb3 Ankrd27 Rabepk Dennd3 Arfrp1 Snap23 Slc2a8 Src Gria1 Arrb2 Arrb1 Cd3g Cd3d Cd4 Ctsz Pip5k1c Pafah1b1 Zw10 Kif18a Dync1h1 Dync1i2 Dync1i1 Cenpe Sec13 Kif2a Kif2b Kif2c Dync1li2 Dync1li1 Dynll1 Dynll2 Wnt5a Kif3a Itsn2 Dvl2 Fzd4 Sar1b Gps1 Apob Trip10 Lrp2 Cops4 Arpc3 Cops2 Arpc2 Cpd Arpc5 Arpc4 Picalm Eps15 Dnm2 Avpr2 Trip11 Actr2 Arpc1a Actr3 Gns Gja10 Gjc1 Gjd2 Gjd4 Gjb2 Gjd3 Gjb1 Gjc2 Gja3 Gjb4 Gjb3 Gja5 Gjb6 Gjb5 Gja4 Gja8 Racgap1 Ocrl Fnbp1 Rps27a Agtr1 Ldlrap1 Uba52 Avp Ubb Ubc Pla2g4a Stam Cftr Ins1 Cd55 Lman1 Scfd1 Actr1a Lman2 Ins2 Sec22a Dctn1 Tfg Dctn2 Cog1 Cog2 Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Adrb2 Cog6 Cog7 Nedd8 Cog8 Napa Nsf Napb Ank1 Grk2 Napg Sec23a Tmem115 Tacr1 Kdelr2 Kdelr3 Sec23ip Sec16b Hgs Sec16a Lman2l Copa Bet1l Cnih1 Gorasp1 Cnih3 Cnih2 Kdelr1 Arf4 Ctsc Arf3 Arf1 Ppp6r3 Mia2 Mia3 Copb2 Stam2 Tmed10 Tmed9 Copb1 Cope Golgb1 Chrm2 Col7a1 Ppp6c Sec31b Sec31a F8 Stx17 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 Syt1 Itsn1 Ap2m1 Gja1 Clta Cltb Myo6 Cltc Dab2 Dnm1 Cbl Cops5 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 96%10224925 Regulation of the apoptosome activity Mapk1 Apip Cycsl2 Diablol1 Casp9 Apaf1 Cycs Xiap Mapk3 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-RNO-351906.1 Apoptotic cleavage of cell adhesion proteins Cdh1 Tjp2 Dsp Ocln Casp3 Tjp1 Dsg1 Dsg2 Ctnnb1 Pkp1 Dsg3 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-RNO-9768919.1 NPAS4 regulates expression of target genes Maged1 Npas4 Arnt2 Bmal1 Arnt BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 96%10225217 Biosynthesis of maresins Ephx2 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a9 Cyp3a62 Cyp3a2 Alox5 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 96%10222567 Coagulation pathway Fgb F10 Procr Fga F12 F11 Fgg Itga2b Proc Klkb1 F13a1 Serpine2 Serping1 Itgb3 Proz Serpina10 Cd177 F2r Kng1 App Serpina5 Sdc4 Sdc3 F2 F8 Sdc2 Serpind1 Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Thbd Smpd1 Gpc6 Pros1 Serpinc1 Sdc1 Tfpi Pf4 Agrn Gp5 Gp9 Gp1bb F13b Serpine1 Gp1ba Ano6 Ano5 F3 F7 F9 Prtn3 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-RNO-1268020.1 Mitochondrial protein import Hscb Fxn Ndufb8 Coq2 Atp5mc3 Pitrm1 Ldhd Otc Atp5f1b Hspd1 NURD COMPLEX ASSEMBLY%REACTOME%R-RNO-9937850.1 NuRD complex assembly Hist1h2ai Ube2i Rbbp4 Rbbp7 H2ac18 Hist1h2bq Hdac1 Hdac2 H2aj Nr2c2 H2ab2 Zmynd8 Ikzf3 Ikzf1 Zfp827 H3-3b Zfp532 Hist3h2ba H2ac4 ENSRNOG00000068602 Phf6 Chd3 Zfp592 Chd4 Cdk2ap1 Mbd2 Nr2f2 Mta1 H2bc18 Chd5 Mta2 Mta3 Tcf19 ENSRNOG00000066901 Mbd3 H2az2 Pwwp2a H2bc4 Mbd3l1 Hist1h4m Mbd3l2 Sumo1 H2bc1 Zfp687 Gatad2a Gatad2b TRANSPORT OF FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%10223999 Transport of fatty acids Slc27a4 Slc27a6 Lcn12 Vegp2 Vegp1 Lcn9 Apod Slc27a1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 96%10223209 Degradation of beta-catenin by the destruction complex Ppp2cb Ppp2ca Gsk3b Ctnnb1 Ctbp2 Tle4 Tle3 Tle2 Tle1 Ppp2r5d Axin1 Tcf7 Tcf7l1 Tcf7l2 Ppp2r1b Psma4 Ppp2r1a Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ctbp1 Amer1 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ppp2r5b Lef1 Ppp2r5a Psmb1 Psmb3 Psmb2 Uba52 Apc Frat2 Btrc Psma7 Frat1 Csnk1a1 Ppp2r5e Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Zranb1 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 96%10223621 Protein-protein interactions at synapses Shank1 Shank3 Homer1 Homer2 Nrxn1 Nrxn2 Nrxn3 Epb41 Epb41l2 Epb41l3 Epb41l5 Lrrtm1 Lrrtm2 Lrrtm3 Lrrtm4 Dlgap1 Homer3 Dlgap4 Dlgap3 Dlgap2 Nlgn2 Nlgn1 Sh3glb2 Nlgn3 Lrrc4b Il1rapl1 Ptprf Il1rapl2 Il1rap Slitrk6 Slitrk4 Slitrk1 Slitrk2 Ppfibp2 Ppfibp1 Flot2 Flot1 Ntrk3 Grin2a Gria4 Gria3 Dlg1 Dlg2 Gria1 Dlg3 Dlg4 Grin1 Grin2d Grin2c Grin2b Cask Grm1 Grm5 Slitrk5 Slitrk3 Ppfia3 Ppfia2 Ppfia4 Lrfn2 Rtn3 Ppfia1 Epb41l1 Lrfn3 Lrfn4 Lrfn1 Ptprs BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-RNO-9026403.1 Biosynthesis of DPAn-3-derived 13-series resolvins Alox5 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 96%10222571 Extracellular matrix organization Adamts3 Adamts2 Fn1 Col4a1 Col4a2 Nid2 Adamts14 P4hb Sdc4 Sdc3 Sdc2 Ctsb Ctss Cdh1 Sdc1 Fgf2 Gpr162 Col14a1 Col10a1 Ppib Col1a2 Col3a1 Col28a1 Col22a1 Col5a2 Col5a3 Col24a1 Col5a1 Col9a2 Col9a3 Pcolce Col20a1 Col11a1 Col11a2 Colgalt1 P3h2 Mmp24 P3h1 Mmp25 Crtap Col18a1 Pcolce2 Adam15 Colgalt2 Optc Col2a1 Adam10 Col27a1 Bsg Col6a2 Htra1 Serpinh1 Col23a1 ENSRNOG00000069479 Mmp20 Col6a5 Mmp11 Col6a6 Eln Col26a1 Col4a5 Mmp12 Itga8 Col6a3 Col8a1 Mmp13 Itgav Mmp14 Col4a6 Bmp10 Col8a2 Adamts5 Vtn Mmp15 Tgfb1 Lum Plod3 Adamts4 Tgfb2 Plod1 Mmp16 Tgfb3 Plod2 Mmp17 Loxl2 Fgb Ltbp3 Mmp19 Bmp1 Fga Ltbp2 Adam8 Loxl1 Fgg Mmp8 Try10 Furin Acan Ltbp4 Prss2l1 Itga2b Ctrb1 Fbln2 Mmp10 Loxl4 Ltbp1 Cast Loxl3 Col15a1 Fbln5 Capn15 Efemp2 Col13a1 Plg Mfap4 Klkb1 Mfap5 Col19a1 Mfap2 Phykpl Itgb8 Spp1 Itgb6 Bmp7 Try5 Gdf5 Cd44 Bmp4 LOC102554637 Capn9 Itgb1 Scube3 Bmp2 Lox Capn8 Scube1 Itgb3 Capn5 Fbn1 Capn7 Capn6 Ddr2 Col25a1 Adam12 Capn1 Ddr1 Timp1 Capn3 Capn2 Timp2 Prss2 Prss3 Tmprss6 Elane Mmp1b Tpsb2 Prss1 Spock3 Capns1 Capn10 A2m Capn11 Capn12 Capn13 Tnc Itga7 Itgax Dmp1 Itga9 Dspp Mmp7 Bcan Mmp2 Vcan Mmp3 Tnn Itga2 Tnr Agrn Mmp9 Tnxb Ncan Dcn Hapln1 Serpine1 Ceacam1 Jam3 Jam2 Prkca Itga3 Itga4 Sntg2 Dtna Dtnb Itga1 Sgcz Snta1 Sntb2 Sntb1 Drp2 Sgce Sgcd Utrn Sgcb Sgca Lama4 Itgal Sspn Dmd Sgcg Col7a1 Itgb2 Tll2 Tll1 Thbs1 Pxdn Ctsd Cd47 Ctsg Itga6 Cma1 F11r Dag1 Adam19 Ctsk Ctsl Pecam1 Itgb4 Megf11 Madcam1 Comp Itgae Itgad Itgb7 Icam1 Icam5 Icam4 Icam2 Itga10 Col4a4 Vcam1 Ibsp MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 96%10222081 Mitochondrial Fatty Acid Beta-Oxidation Hadha Acadvl Hadhb Acadl Echs1 Pctp Hadh Acads Ndufab1 Eci1 Acadm Decr1 Mmut Mecr Mcat Them4 Acad11 Pcca Acaa2 Pccb Acbd6 Acot1 Acsf2 Dbi Acot2 Acot11 Acot12 Acot5 Acot13 Them5 Acot3 Acot9 Acot7 Mmaa INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-RNO-6783589.1 Interleukin-6 family signaling Lifr Crlf1 Jak2 Stat3 Stat1 Il6 Cntf Cntfr Socs3 Clcf1 Cbl Ctf1 Il6r Il31ra Lif Il11 Tyk2 Ptpn11 Osmr Il11ra1 Il6st Osm VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-RNO-196843.1 Vitamin B2 (riboflavin) metabolism Slc52a2 Slc52a3 Rfk Acp5 Flad1 Enpp1 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-RNO-3134963.1 DEx H-box helicases activate type I IFN and inflammatory cytokines production Dhx36 Dhx9 Nfkb2 Nfkb1 Myd88 Irf7 Rela DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 96%10224571 Degradation of AXIN Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Tnks2 Ubb Axin1 Axin2 Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Rnf146 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Tnks Psmd13 Psmb5 Psmb4 Smurf2 Psmb7 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-RNO-72649.1 Translation initiation complex formation Rps14 Rps15 Rps16 Eif2s3 Rps17 Rps15a Rps18 Eif2s2 Rps19 Rps2 Pabpc1 Eif2s1 Rps27 Rpsa Rps10 Rps11 Rps13 Rps4x-ps13 Rps3a Rps27l Rps9 Rps7 Uba52 Rps8 Rps5 Eif4h Rps26-ps13 Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Rps3 Rps25 Rps4x Rps26 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Eif1ax Eif4a2 Eif4a1 Fau Rps6 Eif4e RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10224737 RHO GTPase cycle Mtr Frs2 Frs3 Acbd5 Sptbn1 Aldh3a2 Sptan1 Emd Grb2 Rbmx Sos1 Tra2b Usp9x Iqgap2 Abcd3 Map3k11 Rasgrf2 Rasal2 Csk Itgb1 Atp6ap1 Dock5 Dock6 Steap3 Dock3 Dock4 Dock7 Tfrc Dock8 Dbt Dock10 Dock11 Rab7a Lamtor1 Lbr Kidins220 Als2 Gopc Rhoq Vamp3 Sh3rf1 Ckb Snap23 Pde5a Pak1 Pak2 Tpm4 Rhoa Ngef Ncf1 Zap70 Ncf2 Ncf4 Lck AABR07021573.2 Rhog Rhob Pard6b Pard6a Rac2 Fermt2 Cyba Cybb Dst Actn1 Pik3ca Arhgap32 Cav1 Farp2 Pik3r1 Pik3r2 Pik3r3 Nudc Rbbp6 Aaas Hmox2 Garre1 Shmt2 AABR07032856.1 Osbpl11 Nisch Uaca Nckap1l Itsn2 Stmn2 Scrib Jag1 Fam83b Fam91a1 Mtmr1 Nox3 Nox1 Flot2 Samm50 Flot1 Fam169a Amigo2 Noxa1 Baiap2l2 Rapgef1 Baiap2l1 Letm1 Golga3 Gps1 Fgd5 Taok3 Ralgapa1 Cdc37 Chn2 Esyt1 Trip10 Wwp2 Fam135a Abi2 Abi1 Wdr11 Tuba1b Msi2 Stip1 Cpsf7 Phip Akap12 Stk38 Vrk2 Abl2 Slc1a5 Cops4 Cops2 Srgap1 Ubxn11 Arhgap45 Slk Cpd Cavin1 Daam1 Pgrmc2 Picalm Tex2 Brk1 Bcr Ndufs3 Arhgap6 Jup Dsp Arhgap5 Arhgap15 Arhgap4 Arhgap17 Dsg1 Sowahc Arhgap1 Dsg2 Stom Arap1 Rhobtb2 Arap3 Rhobtb1 Arap2 Arhgap25 Arhgap9 Arhgap8 Arhgap27 Mcam Slitrk5 Slitrk3 Pld1 Arhgap33 Ccdc115 Wasf3 Rtkn Wasf2 Rhpn1 Hsp90ab1 Wasf1 Rhpn2 Stk10 Plekhg1 Ralbp1 Stard8 Maco1 Rnf20 Ddrgk1 Cct6a Faf2 Cdc42bpa Arhgdib Gmip Cdc42bpb Slc4a7 Anln Arhgap10 Iqgap3 Diaph3 Diaph1 Arhgap19 Arhgap18 Depdc1b Senp1 Cit Vangl2 Fam13a Arhgef28 Twf1 Epsti1 C1qbp Arhgap22 Cpne8 Arhgap21 Nckap1 Arhgap20 Nipsnap2 Arhgap26 Ankle2 Arhgap24 Cyfip2 Arhgap23 Cyfip1 Arhgap29 Rhoh Arhgap28 Rhof Rhoc Ophn1 Rhoj Stbd1 Rac3 Dock2 Def6 Kif14 Vapb Rhou Pcdh7 Fam13b Myo9b Emc3 Arhgap11a Cct7 Pak5 Myo9a Arhgap31 Ccdc88a Arhgap30 Tmem59 Prex2 Mtx1 Noxo1 Actc1 Arhgap35 Mpp7 Ankrd26 Fmnl3 Tagap Srgap2 Racgap1 Srgap3 Plekhg6 Ocrl Tmod3 Tmem87a Plekhg3 Cdc42ep1 Bcap31 Cdc42ep4 Ktn1 Plxna1 Farp1 Syde1 Dlc1 Syde2 Pld2 Stard13 Arhgap40 Elmo2 Pkn2 Rras2 Rock2 Arhgef7 Dnmbp Rock1 Nsfl1c Pkn1 Ccdc187 Arhgap44 Plxnd1 Arhgap42 Basp1 Tjp2 Ddx4 Spata13 Nck2 Rnd2 Rac1 Rnd3 Pak3 Rnd1 Git1 Swap70 Arhgdig Baiap2 Kctd13 Fnbp1 Bltp3b Spen Hsp90aa1 Armcx3 Ndufa5 Add3 Tor1aip1 Sema4f Lmnb1 Ptpn13 Fmnl2 Fmnl1 Sh3bp1 Prag1 Vim Hspe1 Tnfaip1 Nck1 Actb Stam Mcf2 Arhgdia Cftr Lman1 Scfd1 Grb7 Arfgap3 Hgs Stam2 Muc13 Peak1 Cep97 Wdr6 Txnl1 Pak6 Rhov Pak4 Ccp110 Git2 Arhgap12 Epha2 Zfp512b Dlg5 Stx5 Ykt6 Ckap4 Arl13b Cct2 Actg1 Ptk2b Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 Sos2 Kalrn Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Abr Fgd3 Arhgef39 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Gja1 Ddx39b Myo6 Cltc Vcp Hnrnpc Cdc42ep2 Cdc42ep3 Cdc42 Cul3 Srrm1 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 96%10225459 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Mphosph8 Hist1h2ai H2aj Atf7ip H2ab2 H3-3b Hist3h2ba H2ac4 Tasor H2ac18 ENSRNOG00000068602 Setdb1 Pphln1 Morc2 H2bc18 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m H2bc1 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-RNO-9037629.1 Lewis blood group biosynthesis St3gal6 St3gal4 B3galt1 St3gal3 Fut2 Fut4 B4galnt2 Fut7 Fut9 B3galt5 B3galt4 St6galnac6 MITOTIC G2-G2 M PHASES%REACTOME%R-RNO-453274.1 Mitotic G2-G2 M phases Ywhag Actr1a Ppp2cb Ppp2ca Gtse1 Dctn1 Dctn2 Prkaca Rab8a Akap9 Phlda1 Ofd1 Prkar2b Ppp2r1b Ppp2r1a Ppp1r12b Ppp1r12a Csnk1d Ccp110 Fbxw11 Ppp1cb Nedd1 Mzt2b Tpx2 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Tp53 Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Nme7 Hsp90ab1 Cep152 Tuba4a Tubgcp2 Haus4 Haus5 Haus6 Pcnt Ccnh Sfi1 Haus1 Fkbpl Tubgcp6 Tubgcp5 Tubgcp4 Tubgcp3 Cep250 Cep290 Bora Cep78 Cep76 Foxm1 Cep72 Ppme1 Lcmt1 Cep164 Cep70 Mis18bp1 Hjurp Cpap Cdc25b Tubb5 Obi1 Plk4 Odf2 Ticrr Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Cdk11b Cdk7 Fbxl7 Mnat1 Psma4 Ccna1 Psma3 Ccna2 Psma6 Psma5 Hsp90aa1 Optn Psma2 Psma1 Rps27a Psmd12 Ppp2r3b Psmd11 Pafah1b1 Psmd14 Cdc25a Psmd13 Ccnb2-ps2 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Ppp2r2a Dync1h1 Ccnb1 Psmb1 Psmb3 Xpo1 Psmb2 Uba52 Dync1i2 Btrc Psma7 Aurka Ajuba Psmc5 Psmc2 Psmc1 Nde1 Psmc4 Psmc3 Wee1 Fzr1 Ubb E2f1 Ubc Nek2l1 E2f3 Psmb6l1 Clasp1 Psmd7 Ywhae Psmd6 Pkmyt1 Psmd8 Plk1 Psmd2 Sgo1 Cdc25c Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdk1 Mapre1 Dynll1 Ccnb2 Ckap5 Csnk1e SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-RNO-399954.1 Sema3A PAK dependent Axon repulsion Hsp90ab1 Plxna4 Pak1 Rac1 Plxna3 Pak3 Plxna2 Pak2 Hsp90aa1 Sema3a Fes Fyn Nrp1 Plxna1 Limk1 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222605 Activation of NOXA and translocation to mitochondria Pmaip1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 96%10222077 Citric acid cycle (TCA cycle) Nfs1 Fxn Sirt3 AC132020.1 Ogdh Dlst Lyrm4 Kgd4 Suclg1 Suclg2 Isca2 Isca1 Dld Trap1 Sdhaf1 Mdh2 Sdhaf2 Sdhaf3 Cs Nnt Idh2 Fh Sdhd Sdhc Sdhb Sdha Iscu Acat1 Aco2 Idh3B Idh3g Sucla2 Idh3a NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223521 Netrin-1 signaling Dscaml1 Ntn4 Dscam Unc5a Rac1 Dcc Prkcq Ptk2 Nck1 Src Fyn Trio Cdc42 Ezr PKR-MEDIATED SIGNALING%REACTOME%R-RNO-9833482.1 PKR-mediated signaling Ppp2cb Ppp2ca Stat3 Stat1 Hspa1b Ube2l6 Hspa1a Ppp2r1b Ppp2r1a Ikbkb Dnajc3 Eif2ak2 Ikbkg Sphk1 Ppp2r5a Fancl Fancm Fanca Fancb Fancc Mapt Fance Fancf Fancg Nck1 Hspa8 Prkra Ilf2 Dus2 Ilf3 Tarbp2 Snca Dhx9 Arih1 Trim25 Ptpn2 Map2k6 Hspa1l Tp53 Faap100 Npm1 Hspa2 Faap24 Isg15 Faap20 Mavs Cdk1 Adar Chuk ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222945 Alternative complement activation C3 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 96%10223567 Enzymatic degradation of Dopamine by monoamine oxidase Maoa Comt SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%10224781 SHC-mediated cascade:FGFR1 Fgf17 Shc1 Fgf10 Nras Grb2 Kras Sos1 Hras Fgf2 Fgf1 Fgf20 Fgf4 Kl Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgfr1 Fgf9 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193807.1 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Hsd3b7 Ncoa2 Akr1d1 Cyp8b1 Akr1c18 Cyp7b1 Akr1c12l1 Akr1c19 Nr1h4 Akr1c21 Cyp27a1 Cyp7a1 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Rxra Akr1c9 SNRNP ASSEMBLY%REACTOME%R-RNO-191859.1 snRNP Assembly Nup133 Nup210 Nup155 Nup153 Ddx20 Snrpepl2 Wdr77 Nup93 Nup50 Gemin6 Snrpf Gemin7 Nup35 Nup54 Nup98 Snrpg Gemin5 Snrpb Nup58 Gemin8 Nup37 Pom121 Prmt5 Nup205 Nup107 Sec13 Tgs1 Nup188 Tpr Smn1 Nup160 Rae1 Snupn Ndc1 Snrpd1 Clns1a Nup85 Nup42 Nup62 Nup43 Nup88 Gemin7l1 Aaas Snrpd3 Ranbp2 Nup214 Gemin2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 96%10222823 Toll Like Receptor 9 (TLR9) Cascade Ppp2cb Ppp2ca Tasl Eea1 Irf5 Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Slc15a4 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Rbsn Tlr9 Rps27a Skp1 Pik3c3 Uba52 Pik3r4 Btrc Ubb Ubc Cul1 Mapk1 Ly96 Ticam2 Irf7 Ticam1 Cd14 Tlr4 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME%R-RNO-380259.1 Loss of Nlp from mitotic centrosomes Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Dync1h1 Csnk1d Ccp110 Dync1i2 Nde1 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Clasp1 Tubg1 Ywhae Cep63 Cep152 Tuba4a Plk1 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Cdk1 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-RNO-5654708.1 Downstream signaling of activated FGFR3 Frs2 Plcg1 Frs3 Fgf2 Fgf1 Fgf4 Fgf5 Fgf8 Fgfr3 Fgf9 Fgf16 Fgf17 Pik3ca Shc1 Fgf18 Pik3r1 Nras Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Gab1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-RNO-2514859.1 Inactivation, recovery and regulation of the phototransduction cascade Grk4 Nmt2 Metap1 Metap2 Camkmt Gucy2e Sag Gucy2f Cnga1 Pde6a Pde6b Gnat1 Rcvrn Guca1b Guca1a Calm3 Nmt1 Rho Gngt1 Gnb5 Fnta Fntb Rgs9bp Ppef1 Pde6g Rgs9 Grk1 Cngb1 TNF SIGNALING%REACTOME%R-RNO-75893.1 TNF signaling Birc2 Mib2 Otulin Ube2d3 Usp2 Ube2d2 Xiap Usp4 Adam17 Madd Tradd Cflar Optn Stub1 Ripk1 Rps27a Fadd Rbck1 Ube2l3 Ikbkb Ulk1 Usp21 Ikbkg Map3k7 Uba52 Smpd2 Smpd3 Traf2 Ube2d1 Sharpin Tnf Otud1 Tnfrsf1a Traf1 Spata2 Rnf31 Rack1 Clip3 Sppl2b Ubb Sppl2a Ubc Casp8 Tbk1 Mapkapk2 Tax1bp1 Ikbke Cyld Nsmaf Tab3 Otud7b Tab2 Tab1 Chuk CGMP EFFECTS%REACTOME DATABASE ID RELEASE 96%10223737 cGMP effects Pde5a Pde11a Irag1 Itpr1 Pde10a Pde2a Pde1b Prkg1 Prkg2 Pde9a Pde1a REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%10225399 Regulation of Expression and Function of Type I Classical Cadherins Suz12 Ddost Eed Ctnnb1 Rbbp4 Rbbp7 Tle1 Src Fyn Ctbp1 Ctsb Cbll1 Ctss Cdh1 Ctnna1 Rack1 Eps15 Dnm2 Jup Mtbp Ctnnd1 Banp Mogs Vcl Hdac2 H2ab2 Twist1 Kmt5a H2ac4 Sec11c Sec11a Prkcsh Sirt1 Zmym2 ENSRNOG00000066901 Pomt1 Dnttip1 Pomt2 Furin Pcsk7 Pcsk6 H2ac18 Ctbp2 Csnk2a2 Ctsl Zeb1 Csnk2a1 Hist1h2bq Hdac1 Ganab Csnk2b Mphosph8 H2aj Canx Arhgap32 Spcs3 Spcs1 Spcs2 Psma4 Smarca4 Pip5k1c Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 H2bc18 H2az2 H2bc4 Kdm1a Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rpn2 Rpn1 Ostc Ost4 Tmem258b Ezh2 Dad1 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-RNO-198725.1 Nuclear Events (kinase and transcription factor activation) Nab2 Ppp2cb Ppp2ca Egr2 Vrk3 Sgk1 Rps6ka3 Rps6ka1 Rps6ka2 Ppp2r5d Dusp3 Srf Dusp4 Dusp7 Creb1 Dusp6 Mapk14 Ppp2r1b Mapkapk2 Ppp2r1a Mapk3 Rps6ka5 Mapk1 Chd4 Mapk11 Atf1 Mapk7 PROTEASOME ASSEMBLY%REACTOME%R-RNO-9907900.1 Proteasome assembly Psmb6 Psmb1 Psmb3 Psmb2 Psme2 Psme1 Psma7 Psmb9 Psmb10 Psmb8 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Psmb6l1 Psmd7 Psmd6 Psmg1 Psmd8 Psmg4 Psmg3 Psmd2 Psma4 Psmd10 Pomp Psmd1 Psma3 Psmd5 Adrm1 Psmd4 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-RNO-163358.1 PKA-mediated phosphorylation of key metabolic factors Mlxipl MITOPHAGY%REACTOME%R-RNO-5205647.1 Mitophagy Map1lc3b Ube2n Uba52 Csnk2a2 Csnk2a1 Ube2d3 Ube2d2 Ubb Ubc Csnk2b Mfn1 Mfn2 Tomm22 Tomm20 Atg5 Tbk1 Atg12 Vdac2 Atg9a Sqstm1 Vdac3 Src Pgam5 Vdac1 Tomm40 Prkn Optn Tomm70 Rps27a Mterf3 Map1lc3a Pink1 Fundc1 Ube2l3 Tomm7 Ulk1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME DATABASE ID RELEASE 96%10222489 Glucagon signaling in metabolic regulation Gcgr Prkar1a Prkar2a Prkar1b Prkar2b Prkaca Prkacb Gcg SLC-MEDIATED BILE ACID TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223807 SLC-mediated bile acid transport Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc44a2 Slc5a7 Slc10a6 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%10222225 Insulin receptor recycling Ins2 Atp6v0b Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Ptprf Atp6ap1 Insr Ptpn1 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Ide Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Ctsd Ins1 METABOLISM OF STEROIDS%REACTOME%R-RNO-8957322.1 Metabolism of steroids Hmgcr Mvd Msmo1 Srebf1 Amacr Akr1c18 Akr1c12l1 Akr1c19 Hsd3b Hsd17b3 Akr1c21 Cyp17a1 Gc Hsd3b6 Scp2 Hsd3b5 Srd5a3 Hsd11b1 Hsd3b1 Hsd11b2 Srd5a1 Hsd17b12 Acox2 Srd5a2 Hsd3b5-ps1 Serpina6 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Alb Pomc Hsd17b4 Akr1c9 Slc27a2 Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Acot8 Lrp2 Pias4 Ube2i Baat Lhb Cga Akr1b10 Sts Kpnb1 Tspoap1 Cyp21 Cyp11b3 Ch25h Ran Osbpl3 Osbpl2 Osbpl1a Osbpl7 Osbpl6 Lgmn Cyp39a1 Sumo3 Osbpl9 Hsd3b7 Ncoa2 Vdr Akr1d1 Cyp8b1 Cyp7b1 Slc10a1 Fabp6 Nr1h4 Abcc3 Stard5 Cyp46a1 Cyp27a1 Osbp Slc27a5 Slc51a Cyp7a1 Slc51b Abcb11 Akr1b1 Stard4 Star Stard6 Cyp11a1 Tspo Fdx2 Fdxr Cyp11b1 Cyp11b2 Cyp19a1 Rxra Ldlrap1 Cyp24a1 Cyp27b1 Scap Fdx1 Mbtps1 Cubn Fdps Plpp6 Idi1 Hsd17b7 Mvk Fdft1 Sqle Ebp Hmgcs1 Arv1 Ggps1 Sc5d Lbr Acat2 Nsdhl Dhcr24 Dhcr7 Lss Slco1a4 Tm7sf2 Srebf2 Slco1b2 Pmvk INTERLEUKIN-18 SIGNALING%REACTOME%R-RNO-9012546.1 Interleukin-18 signaling Il18bp Il18 Il18rap Il18r1 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%10225301 Activation of RAC1 downstream of NMDARs Camk1 Calm3 Camkk1 Camkk2 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-RNO-73856.1 RNA Polymerase II Transcription Termination Cpsf7 Cpsf1 Ncbp2 Cpsf2 Ncbp1 Cpsf3 Snrpepl2 Snrpf Slbp Snrpg Snrpb Pcf11 Fip1l1 Cstf1 Zfp473 Papola Nudt21 Cstf2 Cstf3 Cstf2t Lsm10 Lsm11 Sympk Pabpn1 Snrpd3 Clp1 Cpsf4 Cpsf6 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223173 Glucocorticoid biosynthesis Hsd3b Cyp17a1 Hsd3b6 Cyp21 Hsd3b5 Cyp11b3 Hsd11b1 Hsd3b1 Hsd11b2 Hsd3b5-ps1 Serpina6 Pomc Cyp11b1 Cyp11b2 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 96%10222503 PKA-mediated phosphorylation of CREB Adcy5 Adcy6 Adcy9 Prkar2a Prkar2b Prkaca Prkacb Prkar1a Prkar1b Calm3 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 96%10225415 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Ncoa2 Crebbp H2ac18 Hist1h2bq H2aj Cdk5 H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Med23 Med24 Med20 H2bc18 Med27 Med12 Med1 H2az2 Med13 H2bc4 Med14 Hist1h4m H2bc1 Med10 Rxra Ccnc Med4 Hist1h2ai Paxip1 Pparg Med6 Med16 Tbl1x Med17 Ajuba Pagr1 Med30 Med31 Ppargc1a Ppargc1b Hdac3 Tbl1xr1 Rb1 H2ab2 Ncor2 Gps2 H2ac4 Ncoa3 Sirt1 Abl1 ENSRNOG00000066901 THE NLRP3 INFLAMMASOME%REACTOME%R-RNO-844456.1 The NLRP3 inflammasome Nlrp3 Txn Mefv Pstpip1 Hsp90ab1 P2rx7 Pycard Panx1 Txnip Sugt1 G-PROTEIN ACTIVATION%REACTOME%R-RNO-202040.1 G-protein activation Gng7 Gng8 Gngt1 Gnb2 Oprm1 Gnb1 Gnb4 Gnb3 Gna11 Gnb5 Gng11 Pdyn Gna14 Gng10-ps1 Gng3 Pomc Gng5 Gng4 Gnaq GABA B RECEPTOR ACTIVATION%REACTOME%R-RNO-977444.1 GABA B receptor activation Adcy5 Adcy6 Adcy9 Gnai2 Gnai1 Gnai3 Gng3 Gnal Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Gnat3 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 96%10225451 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes Ncoa2 Crebbp H2ac18 Hist1h2bq H2aj Cdk5 H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Med23 Med24 Med20 H2bc18 Med27 Med12 Med1 H2az2 Med13 H2bc4 Med14 Hist1h4m H2bc1 Med10 Rxra Ccnc Med4 Hist1h2ai Pparg Med6 Med16 Tbl1x Med17 Ajuba Med30 Med31 Ppargc1a Ppargc1b Hdac3 Tbl1xr1 Rb1 H2ab2 Ncor2 Gps2 H2ac4 Ncoa3 Sirt1 Abl1 ENSRNOG00000066901 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-RNO-2046104.1 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Fads1 Elovl2 Elovl3 Abcd1 Elovl5 Elovl1 Scp2 Acox1 Acsl1 Acaa1b Hsd17b4 Acot8 Fads2 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%10225031 Activation of the TFAP2 (AP-2) family of transcription factors Cited2 Wwox Tfap2c Tfap2a Tfap2b Yeats4 Crebbp Tfap2e Ep300 Cited4 Cited1 CA-DEPENDENT EVENTS%REACTOME%R-RNO-111996.1 Ca-dependent events Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkar2a Prkar2b Pde1b Pde1c Pde1a Mapk1 Pla2g4a Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 CALCINEURIN ACTIVATES NFAT%REACTOME%R-RNO-2025928.1 Calcineurin activates NFAT Fkbp1a Calm3 Ppp3ca Ppp3cb Nfatc1 Nfatc3 Nfatc2 Ppp3r1 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 96%10222539 Activation, translocation and oligomerization of BAX Bid Bax APOPTOSIS%REACTOME DATABASE ID RELEASE 96%10222195 Apoptosis Ywhag Apip Casp7 Apaf1 Diablol1 Ctnnb1 Prkcq Prkcd Septin4 Bak1 Nmt1 Gzmb Bid Xiap Gsn Casp6 Gas2 Sh3glb2 Add1 Ptk2 Mapk3 Tradd Sptan1 Cflar Ripk1 Tnfsf10 Fas Fadd Faslg Bcl2l1 Acin1 Bmf Mapk8 Opa1 Oma1 Gsdme Gsdmd Apc Traf2 Tjp1 Dsg3 Cdh1 Dsp Dsg1 Dsg2 Kpnb1 Hmgb1-ps34 Ppp3r1 Kpna1 Clspn Casp8 Cycsl2 Dcc Appl1 Pkp1 Hmgb1l2 Hmgb1l1 H1-1 Lmna H1-0 H1-5 H1-4 H4f3 Hmgb2 Fnta Dffa Dffb Cycs Ywhab Ocln Birc2 Bax Plec Bcap31 Satb1 Rock1 Tjp2 Bcl2l11 Stk26 Stk24 Dnm1l Lmnb1 Sfn Vim Mapt Ppp3cc Pmaip1 Bad Casp3 Casp9 Ywhae Mapk1 Bmx Dynll1 Dynll2 Ywhaq Ywhah Ly96 Ticam2 Ticam1 Cd14 Tlr4 Ywhaz SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 96%10223681 Signal amplification Gna13 P2ry1 Gnai2 Gnai1 Gnai3 Gna11 Aamp Gna14 Gng3 Gng5 Gng4 Gnaq Gng7 Gng8 Gngt1 Gnat3 Mapk14 Gnb2 Src Gnb1 Tbxa2r Gnb4 Gnb3 Gnb5 Pla2g4a Gng11 P2ry12 Gng10-ps1 IRS-MEDIATED SIGNALLING%REACTOME%R-RNO-112399.1 IRS-mediated signalling Irs2 Pik3r4 Pdpk1 Frs2 Klb Irs1 Trib3 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgfr3 Fgf7 Fgfr4 Fgf9 Fgfr1 Fgfr2 Fgf16 Them4 Pde3b Tlr9 Fgf17 Pik3ca Fgf18 Fgf19 Gab2 Fgf10 Akt2 Pik3r1 Pik3cb Grb2 Pik3r2 Sos1 Ptpn11 Fgf20 Kl Fgf23 Flt3 Fgf22 Pik3c3 Gab1 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-RNO-9013700.1 NOTCH4 Activation and Transmission of Signal to the Nucleus Notch4 Ywhaz TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%10223283 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Tnfsf13b Tnfsf11 Lta Ltb Traf2 Tnfsf14 Tnfsf12 Birc2 Tnfrsf13c Ltbr Tnfrsf12a Map3k14 Traf3 Tnfrsf11a Cd40lg Cd40 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%10224933 Regulation of PTEN localization Rps27a Uba52 Pten Nedd4 Xiap Ubb Ubc Usp7 Pml SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 96%10223459 Synthesis of 5-eicosatetraenoic acids Pon2 Alox5ap Alox5 Pon3 Ltc4s Pon1 DEGRADATION OF CDH1%REACTOME%R-RNO-9766229.1 Degradation of CDH1 Ctnnb1 Ctsl Psma4 Psma3 Psma6 Src Psma5 Psma2 Psma1 Rps27a Psmd12 Fyn Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Ctsb Cbll1 Ctss Cdh1 Psmc5 Ctnna1 Psmc2 Rack1 Psmc1 Eps15 Psmc4 Dnm2 Psmc3 Jup Mtbp Ctnnd1 Banp Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%10222595 Activation of BAD and translocation to mitochondria Ywhag Ywhae Bad Ywhaq Ppp3cc Ywhah Sfn Ywhab Ppp3r1 Ywhaz ADRENOCEPTORS%REACTOME%R-RNO-390696.1 Adrenoceptors Adrb2 Adrb1 Adra1b Adra2b Adrb3 Adra1a Adra1d Adra2a Adra2c DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223085 Digestion and absorption Cel Pnliprp2 Pnliprp1 Gucy2c Si Lipf Slc2a2 Pir Amy2 Alpi Guca2b Guca2a Lct Clps Chia Pnlip Npc1l1 Slc5a1 Slc2a5 Chit1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%10222765 Glucagon-type ligand receptors Sct Gcgr Sctr Gng3 Adcyap1 Gng5 Vip Gng4 Ghrh Gng7 Gng8 Gngt1 Gcg Gnb2 Ghrhr Gip Gnb1 Gnb4 Gnb3 Gnb5 Glp1r Gng11 Gng10-ps1 Gipr Vipr2 Vipr1 Gnas Glp2r GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME%R-RNO-9840309.1 Glycosphingolipid biosynthesis St8sia5 Fut2 Fut1 St6galnac5 B3galt4 St6galnac6 A4galt Cerk B3galnt1 Ugcg B4galnt1 St3gal5 Ugt8 St3gal2 Gal3st1 St3gal3 B4galt5 B4galt6 B3gnt5 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-RNO-8849471.1 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Pxn Bcar1 Rac1 Rhoa Arhgap35 Nras Rasa1 Kras Hras Elmo1 Elmo2 Crk Ptk6 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-RNO-73776.1 RNA Polymerase II Promoter Escape Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Mnat1 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Ccnh Taf7l-ps1 Gtf2a1 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Polr2c Taf4 Polr2a Taf2 Polr2b Taf1 Polr2g Gtf2e2 Polr2h Polr2e Polr2f Polr2i MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-RNO-9841922.1 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Ncoa2 Crebbp H2ac18 Hist1h2bq H2aj Cdk5 H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Med23 Med24 Med20 H2bc18 Med27 Med12 Med1 H2az2 Med13 H2bc4 Med14 Hist1h4m H2bc1 Med10 Rxra Ccnc Med4 Hist1h2ai Pparg Med6 Med16 Tbl1x Med17 Ajuba Med30 Med31 Ppargc1a Ppargc1b Hdac3 Tbl1xr1 Rb1 H2ab2 Ncor2 Gps2 H2ac4 Ncoa3 Sirt1 Abl1 ENSRNOG00000066901 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225327 Drug-mediated inhibition of ERBB2 signaling Erbb2 Cdc37 Hsp90aa1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 96%10222525 E2F mediated regulation of DNA replication Prim2 Prim1 Ppp2cb Rb1 Ppp2r3b Ppp2ca Ppp2r1b Ppp2r1a Pola2 Pola1 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-RNO-432047.1 Passive transport by Aquaporins Aqp12a Aqp1 Aqp4 Aqp3 Aqp2 Aqp9 Aqp8 Aqp7 Aqp5 Aqp11 Mip Aqp10 CHD1 AND CHD2 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%10225539 CHD1 and CHD2 subfamily Sf3b1 Hist1h2ai Puf60 Sf3b3 Leo1 Sf3b4 Sf3b5 Snrpepl2 H2ac18 Phf5a Smndc1 Ssrp1 Hist1h2bq Snrpf U2surp Snrpg Skic8 Snrpb Snrpn H2aj Cherp H2ab2 Snrpa1 Rbm17 Ddx46 H3-3b Hist3h2ba H2ac4 Ddx42 Ctr9 Cdc73 ENSRNOG00000068602 Paf1 Snrpd1 Chd1 Chd2 H2bc18 ENSRNOG00000066901 H2az2 Dhx15 H2bc4 Snrpd3 Sf3a1 Hist1h4m Sf3a2 H2bc1 Sf3a3 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-RNO-500753.1 Pyrimidine biosynthesis Umps Cad Dhodh CAM-PDE 1 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222515 Cam-PDE 1 activation Calm3 Pde1b Pde1c Pde1a FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-RNO-6781823.1 Formation of TC-NER Pre-Incision Complex Polr2j Xab2 Gtf2h2 Gtf2h1 Uba52 Gtf2h3 Cdk7 Gtf2h5 Cops4 Ercc2 Ppie Ercc3 Cops2 Tcea1 Cops7a Cops7b Znf830 Mnat1 Aqr Uvssa Prpf19 Ubb Ubc Usp7 Rbx1 Ccnh Cops3 Cops6 Cops8 Isy1 Gps1 Rps27a Polr2c Polr2a Polr2b Cops5 Polr2g Polr2h Polr2e Xpa Polr2f Ercc6 Ddb1 Polr2i Cul4a Cul4b CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 96%10222617 Clearance of seratonin Maoa Slc6a4 Aldh2 MISCELLANEOUS SUBSTRATES%REACTOME DATABASE ID RELEASE 96%10223427 Miscellaneous substrates Cyp2s1 Cyp3a9 Cyp3a18 Cyp2w1 Cyp4f39 Cyp4f1 Cyp4a14 Cyp4f3 Cyp3a1 Cyp4a12 Cyp4f40 Cyp2d4 Cyp4b1 Cyp3a62 Cyp3a2 Cyp2u1 Cyp4f4 Cyp4a10 Cyp4a2 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 96%10224807 TNFs bind their physiological receptors Tnfsf13b Tnfsf11 Tnfsf8 Tnfsf9 Tnfrsf9 Lta Tnfrsf17 Edaradd Tnfsf15 Tnfrsf1a Tnfsf18 Tnfrsf25 Tnfsf13 Eda2r Tnfrsf18 Eda Tnfrsf4 Tnfrsf8 Tnfrsf1b Edar Tnfrsf11b Tnfsf4 HYDROLYSIS OF LPE%REACTOME DATABASE ID RELEASE 96%10224237 Hydrolysis of LPE Pla2g4c NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%10224683 NIK-->noncanonical NF-kB signaling Psmb6 Psmb1 Psmb3 Psmb2 Relb Uba52 Nfkb2 Fbxw11 Btrc Psma7 Psmc5 Psmc2 Ube2m Psmc1 Uba3 Psmc4 Psmc3 Map3k14 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Chuk Skp1 Psmb5 Psmb4 Psmb7 SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 96%10222917 Signaling by NODAL Mapk1 Smad2 Smad3 Smad4 Mapk3 Foxo3 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME%R-RNO-9954716.1 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Ube2d3 Rplp1 Ube2d2 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Trip4 Rps27a Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Ube2d1 Rpl7 Rps26-ps13 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Ubb Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Ascc3 Rpl23 Ascc2 Fau Zfp598 LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-RNO-162699.1 Synthesis of dolichyl-phosphate mannose Dpm2 Dpm1 Dpm3 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 96%10225465 Maturation of TCA enzymes and regulation of TCA cycle Nfs1 Fxn Isca2 Isca1 Sdhaf1 Sdhaf2 Sdhaf3 Idh2 Sirt3 Sdhd Sdhc Sdhb Sdha Iscu Acat1 Aco2 Lyrm4 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%10224465 TRIF-mediated programmed cell death Ripk1 Casp8 Fadd Ly96 Ticam2 Ripk3 Ticam1 Cd14 Tlr4 DNA DAMAGE BYPASS%REACTOME%R-RNO-73893.1 DNA Damage Bypass Wdr48 Ufd1 Uba52 Usp10 Rad18 Pole3 Pole2 Ube2l6 Pole4 Rchy1 Ube2b Rpa1 Rpa2 Polk Trim25 Ubb Rpa3 Ubc Polh Mad2l2 Rev1 Rev3l Poli Pole Rfc5 Pold2 Pold1 Isg15 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Rfc2 Pold4 Vcp Pclaf Pold3 Usp43 Rps27a Usp1 Dtl Nploc4 Sprtn Uba7 Ddb1 Cul4a Cul4b FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-RNO-5654706.1 FRS-mediated FGFR3 signaling Fgf16 Fgf17 Fgf18 Frs2 Frs3 Nras Grb2 Kras Sos1 Hras Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Fgf9 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 96%10222209 Activation of the phototransduction cascade Rho Gngt1 Cnga1 Pde6a Pde6b Gnat1 Pde6g Gnb1 Cngb1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%10224343 Activated NOTCH1 Transmits Signal to the Nucleus Itch Rps27a Dtx4 Uba52 Ubb Ubc Dtx2 CARDIAC CONDUCTION%REACTOME%R-RNO-5576891.1 Cardiac conduction Slc8a1 Slc8a2 Slc8a3 Prkaca Cacna1c Calm3 Nos1 Kcna5 Akap9 Kcne5 Kcnq1 Kcne4 Kcne3 Kcne2 Kcnh2 Cacnb1 Cacnb2 Itpr3 Kcnk4 Itpr2 Kcnk2 Itpr1 Kcnj4 Kcnk1 Atp2a1 Cacng4 Kcnk10 Kcnk16 Cacna2d2 Atp2a3 Kcnj2 Kcnk9 Atp2a2 Kcnk7 Kcnk18 Kcnj14 Kcnk6 Kcnj11 Kcnj12 Abcc9 Cacng6 Cacng7 Atp2b1 Camk2g Kcnd3 Atp2b4 Camk2d Kcnd2 Atp2b3 Kcnd1 Camk2b Kcnip3 Kcnip4 Kcnip1 Kcnip2 Kcnk12 Kcnk15 Sri Npr1 Camk2a Npr2 Kcnk5 Corin Nppc Atp1b1 Nppa Atp1b3 Atp1b2 Ryr2 Ryr1 Fkbp1b Dmpk Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Clic2 Trdn Ahcyl1 Pln Asph Trpc1 Stim1 Tnni3 Cacng8 Mme Kcnk13 Ces1d FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-RNO-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis Prkcd Nckap1l Wipf3 Plpp4 Wipf1 Plpp5 Pld3 Pak1 Ptk2 Mapk3 Lyn Yes1 Src Grb2 Fyn Abi2 Abi1 Arpc3 Arpc2 Cd3g Arpc5 Arpc4 Brk1 Elmo1 Pld1 Wasf3 Wasf2 Hsp90ab1 Wasf1 Arpc1b Actr2 Arpc1a Actr3 Btk Abl1 Nckap1 Cyfip2 Cyfip1 Myo9b Nckipsd Plcg1 Pld4 Myo5a Pld2 Actg1 Elmo2 Pik3ca Rac1 Baiap2 Pik3r1 Pik3cb Hsp90aa1 Vav3 Pik3r2 Vav1 Vav2 ENSRNOG00000069193 Limk1 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 Myh9 ENSRNOG00000066406 Myo10 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Syk Iglc1 Nck1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Fgr Actb ENSRNOG00000065564 Hck ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 Myo1c ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Plcg2 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 Pla2g6 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 Prkce ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Mapk1 Cdc42 Crk ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 96%10222389 Activation of PKB Them4 Pdpk1 Trib3 Akt2 THE NLRP1 INFLAMMASOME%REACTOME%R-RNO-844455.1 The NLRP1 inflammasome Nlrp1a Bcl2l1 CDC42 GTPASE CYCLE%REACTOME%R-RNO-9013148.1 CDC42 GTPase cycle Ophn1 Def6 Fam13b Myo9b Arhgap31 Arhgap30 Prex2 Arhgap35 Srgap2 Tagap Srgap3 Racgap1 Plekhg3 Ktn1 AABR07032856.1 Syde1 Farp1 Dlc1 Stard13 Arhgap40 Dnmbp Arhgap44 Arhgap42 Spata13 Tiam1 Arhgap32 Mcf2l Cav1 Arhgef15 Arhgdig Arhgef16 Arhgef11 Pik3r1 Arhgef10 Arhgef12 Ngef Arhgef19 Vav3 Pik3r2 Dock6 Vav2 Itsn1 Arhgef26 Dock7 Arhgef25 Dock8 Arhgef6 Arhgef5 Arhgef4 Gna13 Fgd2 Arhgef9 Fgd1 Fgd4 Srgap1 Abr Dock10 Arhgap45 Fgd3 Dock11 Ykt6 Ect2 Prex1 Bcr Trio Arhgap5 Arhgap17 Arhgap4 Arhgap1 Plekhg2 Arap1 Arap3 Arap2 Arhgap9 Arhgap27 Arhgap33 Plekhg1 Ralbp1 Stard8 Arhgdib Gmip Arhgap10 Rasgrf2 Depdc1b Lbr Arhgap22 Cdc42 Arhgap21 Arhgap20 Mcf2 Arhgap26 Arhgdia Arhgap24 Arhgap29 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-RNO-8866652.1 Synthesis of active ubiquitin: roles of E1 and E2 enzymes Uba52 Uchl3 Ube2d1 Ube2w Uba1 Ube2k Ube2t Otulin Cdc34 Ube2b Ube2d2 Ube2a Ubb Ubc Usp5 Usp7 Ube2e1 Ube2g2 Ube2g1 Ube2z Ube2s Rps27a Ube2c Ube2r2 Ube2l3 Uba6 Usp9x Ube2e3 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 96%10223007 Plasma lipoprotein assembly Bmp1 Zdhhc8 Prkaca Prkacb Mttp Apoc1 Apoc2 A2m Apoa1 Apoc4 Apoc3 Apoa2 Sar1b Apoe Apoa4 P4hb Abca1 Apob HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223095 Heme biosynthesis Abcg2 Uros Alas1 Alas2 Hmbs Cpox Fech Alad Alb Ppox Cox10 Cox15 Urod RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225349 RND1 GTPase cycle Stip1 Wdr6 Txnl1 Grb7 Kif14 Epha2 Frs2 Dlg5 Ccdc88a Frs3 Tmem59 Ubxn11 Arhgap35 Cpd Ankrd26 Dst Dsp Arhgap5 Plxna1 Plekhg5 Rras2 Stmn2 Fam83b Cav1 Rnd1 Flot2 Aldh3a2 Pik3r1 Pik3r2 Rbmx Depdc1b Ptpn13 Vangl2 Tfrc Epsti1 Muc13 Fam135a Kidins220 Rasal2 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 96%10222563 Response to elevated platelet cytosolic Ca2+ Aldoa Serpina3n Timp3 Fam3c Prkcg Serpinf2 Prkca Tln1 F13a1 Anxa5 Fn1 Calm3 Qsox1 Pdgfa Pdgfb Brpf3 Vegfa Lgals3bp Alb Vegfd Vegfc Lamp2 Vegfb Wdr1 Apoa1 Maged2 Kng1 Endod1 App Serpina4 F8 Actn2 Habp4 Cdc37l1 Serpina1 Tagln2 Cd36 Itih4 Itih3 Pros1 Cd109 Nhlrc2 Fermt3 Lefty2 Thbs1 Manf AABR07021573.2 Lefty1 Igf2 Igf1 Hgf Sparc Apoh Vcl Gtpbp2 Orm1 Ecm1 Tuba4a Ola1 Prkcb Ctsw Psap Actn4 Ppbp Flna Tmsb4x Cd63 Tor4a Tgfb1 Tgfb2 Tgfb3 Fgb Fga Fgg Pcdh7 Tmx3 Itga2b Scg3 Selp Plg Cyrib Sccpdh Egf Srgn Serping1 Pecam1 Itgb3 Clu Actg1 Actn1 Aplp2 Timp1 Cyb5r1 Mmrn1 Cd9 Plek Sod1 A2m Tf Phactr2 Stxbp2 Stxbp3 Vti1b Chid1 Abcc4 Cfd Pf4 A1bg Rab27b Serpine1 Islr Pcyox1l Hrg Lhfpl2 Gas6 Sytl4 Ly6g6f Ahsg Spp2 Stx4 NEDDYLATION%REACTOME DATABASE ID RELEASE 96%10224847 Neddylation Rbbp7 Ube2d3 Ube2d2 Gps1 Nploc4 Kbtbd7 Commd9 Fbxw11 Cops4 Cops2 Commd3 Psma4 Psma3 Psma6 Cops3 Psma5 Cops6 Psma2 Cops8 Psma1 Rps27a Psmd12 Dtl Psmd11 Psmd14 Psmd13 Skp2 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Nub1 Neurl2 Commd8 Ube2d1 Fem1b Fem1a Tulp4 Btrc Fem1c Psma7 Dcaf8 Dcaf4 Dcaf5 Dcaf6 Psmc5 Dcaf7 Psmc2 Ccdc22 Psmc1 Obsl1 Psmc4 Cops7a Dda1 Psmc3 Cops7b Ccdc8 Commd4 Commd5 Commd6 Commd7 Commd2 Spsb3 Ubb Ankrd9 Socs2 Ubc Commd10 Socs6 Psmb6l1 Ubd Wdtc1 Psmd7 Dcun1d5 Dcun1d4 Psmd6 Dcun1d3 Psmd8 Cish Dcun1d2 Psmd2 Dcun1d1 Cul9 Psmd1 Dcaf17 Dcaf10 Adrm1 Cul1 Dcaf11 Epas1 Hif3a Hif1a Keap1 Ddb2 Ufd1 Uchl3 Lrr1 Fbxl21 Wsb1 Ccnf Nedd8 Mul1 Kbtbd8 Fbxw4 Fbxw5 Fbxw7 Gan Fbxw8 Fbxw9 Fbxw2 Klhl5 Klhl3 Klhl2 Senp8 Spsb2 Spsb1 Spsb4 Eloc Elob Kctd7 Kctd6 Ube2m Ube2f Fbxo10 Fbxo11 Fbxo15 Fbxo17 Lmo7 Lrrc41 Klhl13 Klhl11 Fbxo21 Fbxo22 Fbxo27 Cand1 Fbxw17 Klhl25 Klhl21 Btbd6 Socs5 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Zbtb16 Cul2 Cul5 Cul7 Fbxo41 Fbxo44 Wdr5 Nfe2l2 Klhl41 Fbxo40 Btbd1 Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Fbxo4 Fbxo6 Rbbp5 Fbxo7 Fbxo9 Vhl Fbxl15 Fbxl16 Fbxl19 Asb9 Asb7 Asb6 Asb5 Asb4 Asb1 Ubxn7 Rbx1 Socs3 Vcp Cop1 Cops5 Birc5 Cul3 Ddb1 Dcaf13 Cul4a Cul4b NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222153 Nucleotide biosynthesis Atic Adsl Ppat Adss2 Pfas Paics Gart Adss1 Umps Cad Gmps Dhodh Impdh2 Impdh1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223721 P2Y receptors P2ry10 P2ry4 P2ry13 P2ry12 P2ry1 Lpar6 Lpar4 P2ry14 P2ry2 Gpr17 P2ry6 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-RNO-450604.1 KSRP (KHSRP) binds and destabilizes mRNA Parn Khsrp Dis3 Akt1 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Exosc6 Exosc1 Dcp2 Exosc3 Exosc2 Ywhaz ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 96%10222537 Activation and oligomerization of BAK protein Bak1 Bid L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10222409 L1CAM interactions Itga2b Ranbp9 Csnk2a2 Csnk2a1 Itgb1 Ank1 Itgb3 Sdcbp Fgfr1 Csnk2b Spta1 Rac1 Pak1 Ncam1 Sptb Sptbn1 Sptbn2 Mapk3 Nfasc Sptan1 Src Sptbn5 Sptbn4 Vav2 Map2k2 Map2k1 Dnm2 Nrp1 Ap2m1 Itga9 Clta Cltc Egfr Dnm1 Lypla2 Gap43 Dpysl2 Kif4b Ap2s1 Kif4a Mapk1 Rdx Msn L1cam Dnm3 Ap2a2 Ap2a1 Ap2b1 Numb Sh3gl2 Ezr Itgav MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-RNO-1362409.1 Mitochondrial iron-sulfur cluster biogenesis Nfs1 Hscb Fxn Isca2 Isca1 Fdx2 Iscu Fdxr Fdx1 Glrx5 Lyrm4 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 96%10223757 Nectin Necl trans heterodimerization Nectin2 Pvr Nectin4 Cadm3 Cadm1 Nectin1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 96%10224227 Assembly of collagen fibrils and other multimeric structures Loxl2 Bmp1 Loxl1 Loxl4 Tll2 Tll1 Col15a1 Loxl3 Ctsb Ctss Ctsl Lox Col10a1 Mmp7 Col3a1 Mmp3 Col5a2 Col4a1 Col5a3 Col24a1 Col4a2 Mmp9 Col5a1 Pcolce Col11a1 Col11a2 Pxdn Col18a1 Col2a1 Col27a1 Col7a1 Mmp20 Mmp13 Col8a1 Col8a2 HYPUSINYLATION%REACTOME%R-RNO-204626.1 Hypusinylation Eif5a2 Dohh Dhps Eif5a SIGNALING BY NTRK3 (TRKC)%REACTOME%R-RNO-9034015.1 Signaling by NTRK3 (TRKC) Plcg1 Src Ntrk3 Ntf3 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224183 Voltage gated Potassium channels Kcna10 Kcnb1 Kcna2 Kcns3 Kcnc4 Kcna1 Kcnc2 Kcnc3 Kcng2 Kcnc1 Kcng4 Kcng3 Kcng1 Kcnh1 Kcnv2 Kcnv1 Kcna5 Kcnq1 Kcnh2 Kcnb2 Kcnh8 Kcnh7 Kcnh6 Kcnh5 Kcnh4 Kcnd3 Kcnf1 Kcnd2 Kcnh3 Kcnd1 Kcnq5 Kcnab1 Kcns2 Kcns1 Kcnab3 Kcnab2 Kcna7 Kcna6 Kcna4 Kcna3 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-RNO-8854691.1 Interleukin-20 family signaling Ifnl1 Ifnl3 Jak2 Stat3 Stat1 Ifnlr1 Il20rb Jak3 Il20ra Tyk2 Il22ra2 Ptpn11 Il10rb Il22 Il20 Stat5a Il24 Stat5b Il22ra1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%10222529 Cytochrome c-mediated apoptotic response Mapk1 Casp3 Casp7 Apip Cycsl2 Diablol1 Casp9 Apaf1 Cycs Xiap Mapk3 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-RNO-6782315.1 tRNA modification in the nucleus and cytosol Qng1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 96%10222581 Elevation of cytosolic Ca2+ levels P2rx1 Trpc3 Itpr3 Itpr2 P2rx7 Itpr1 P2rx6 P2rx5 P2rx4 P2rx3 Trpc7 P2rx2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-RNO-112382.1 Formation of RNA Pol II elongation complex Iws1 Cdk7 Ell Ccnk Tcea1 Ccnt2 Ssrp1 Eloa2l Mnat1 Eloa Aff4 Supt6h Cdc73 Polr2c Polr2a Polr2b Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe Polr2j Ctdp1 Mllt3 Ncbp2 Mllt1 Ncbp1 Gtf2h2 Leo1 Gtf2h1 Supt4h1 Eloc Gtf2f2 Gtf2f1 Elob Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Cdk9 Skic8 Eaf1 Eaf2 Ccnh Ctr9 Paf1 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 96%10223749 Regulation of actin dynamics for phagocytic cup formation Nckap1l Wipf3 Wipf1 Pak1 Ptk2 Mapk3 Grb2 Abi2 Abi1 Arpc3 Arpc2 Cd3g Arpc5 Arpc4 Brk1 Elmo1 Wasf3 Wasf2 Hsp90ab1 Wasf1 Arpc1b Actr2 Arpc1a Actr3 Btk Abl1 Nckap1 Cyfip2 Cyfip1 Myo9b Nckipsd Myo5a Actg1 Elmo2 Rac1 Baiap2 Hsp90aa1 Vav3 Vav1 Vav2 ENSRNOG00000069193 Limk1 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 Myh9 ENSRNOG00000066406 Myo10 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Syk Iglc1 Nck1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Actb ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 Myo1c ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Mapk1 Cdc42 Crk SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 96%10224133 Signaling by ERBB4 Wwox Aph1b Wwp1 Erbb3 Ereg Uba52 Esr1 Nrg2 Nedd4 Nrg3 Btc Egf Ubb Stat5a Ubc Egfr Pik3ca Shc1 Yap1 Hbegf Src Pik3r1 Nras Itch Rps27a Grb2 Kras Sos1 Hras Psenen Psen1 Psen2 Ncstn Aph1a RET SIGNALING%REACTOME%R-RNO-8853659.1 RET signaling Rap1gap Irs2 Grb7 Dok2 Shank3 Prkaca Frs2 Prkacb Dok1 Plcg1 Pdlim7 Dok4 Dok5 Dok6 Prkca Grb10 Ret Pik3ca Shc3 Shc1 Pspn Gab2 Gdnf Src Artn Pik3r1 Pik3cb Gfra1 Gfra2 Grb2 Pik3r2 Gfra4 Pik3r3 Pik3cd Sos1 Ptpn11 Nrtn Mapk7 Gab1 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-RNO-429958.1 mRNA decay by 3' to 5' exoribonuclease Skic8 Dcps Dis3 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Exosc6 Exosc1 Nt5c3b Exosc3 Hbs1l Exosc2 Skic3 Skic2 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-RNO-427975.1 Proton oligopeptide cotransporters Slc15a1 Slc15a3 Slc15a4 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 96%10222531 Apoptotic factor-mediated response Gsdme Casp7 Apip Gsdmd Cycsl2 Diablol1 Apaf1 Mapk3 Bax Septin4 Mapk1 Bak1 Casp3 Casp9 Cycs Xiap POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%10225119 Post-translational protein phosphorylation Ttgn1 Men1 Igfbp3 Fn1 Qsox1 Alb Serpina10 Notum Apoa1 Apoa2 Kng1 Mia3 Apoe P4hb Apob App Fgf23 Sdc2 Serpind1 Serpina1 Gpc3 Serpinc1 Ckap4 Cdh2 Il6 Prkcsh Adam10 C3 Hsp90b1 Fga Fgg Scg3 Ltbp1 Proc Spp1 Bmp4 Ktn1 Fbn1 Aplp2 C4b Timp1 Megf11 Chgb Pdia6 C4 Ccn1 Amelx Lgals1 Csf1 Scg2 Apoa5 Meltf Mxra8 Fam20a LOC120093819 Fam20c Tf Fuca2 Stc2 Wfs1 Apol7al1 Hrc Pcsk9 Ambn Mepe Cp Dnajc3 Apol2 Enam Bmp15 Bpifb2 Apol7bl1 Ano8 Penk Igfbp7 Mfge8 Matn3 Rcn1 Vgf Vwa1 Fstl1 Fstl3 Chrdl1 Prss23 Tmem132a Afp Pnpla2 Mbtps1 Igfbp5 Igfbp4 Tnc Golm1 Igfbp1 Amtn Dmp1 Mgat4a Nucb1 Sparcl1 Msln Vcan Cst3 Itih2 Apol9a Gas6 Ahsg Spp2 HISTAMINE RECEPTORS%REACTOME%R-RNO-390650.1 Histamine receptors Hrh1 Hrh4 Hrh2 Hrh3 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 96%10222149 Formation of a pool of free 40S subunits LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Eif3m Eif3j Eif3i Rpl30 Eif3l LOC134486107 Eif3k Rpl31 Eif3f Rpl32 Eif3e Eif3h Rpl34 Eif3g Rpl36al1 Eif3b Eif3a Rpl39l1 Eif3d Rpl24 Eif3c Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Eif1ax Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%10225425 MITF-M-dependent gene expression Lef1 Tcf7l1 Rab27a Tcf7l2 Ctnnb1 Sin3a Hint1 Mitf Myo5a Myrip Sytl2 Hdac1 Tcf7 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 96%10224203 TWIK-related alkaline pH activated K+ channel (TALK) Kcnk16 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225441 TGFBR3 regulates FGF2 signaling Tgfbr3 Gipc1 Fgf2 ONCOGENE INDUCED SENESCENCE%REACTOME%R-RNO-2559585.1 Oncogene Induced Senescence Uba52 Id1 Cdk6 Ets1 Mapk3 Ets2 Mapk1 Rps27a Cdkn2b Cdkn2d Mdm4 Erf Cdk4 Ubb Ubc Tp53 MRNA 3'-END PROCESSING%REACTOME%R-RNO-72187.1 mRNA 3'-end processing Ppp1ca Srrm2 Snrpepl2 Hnrnph2 Hnrnph1 Papolg Ppp1r8 Rbm25l1 Prr3 Ybx1 Dnajc8 Rbm25 Rbm5 Rbm17 Ddx46 Ddx42 Pcf11 Fip1l1 Cstf1 Rbmx Papola Nudt21 Polr2c Tra2b Cstf2 Polr2a Cstf3 Polr2b Polr2g Cstf2t Polr2h Sympk Polr2e Polr2f Pabpn1 Clp1 Cpsf4 Polr2i Cpsf6 Cpsf7 Polr2j Cpsf1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Gtf2f2 Gtf2f1 Ppp1cb Phf5a Hnrnpr-ps2 U2surp Snrpa1 Ptbp1 Tut1 Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b3 Sf3b4 Sf3b5 Hnrnpa2b1 Srrt Snrnp70 Htatsf1 Snrpa Snrpc Snrpn Cherp Fus Rps27a Srsf1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Hnrnpa3 Puf60 U2af1 Uba52 Hnrnpa1 Rbbp6 U2af1l4 Tcerg1 Smndc1 Dhx9 Prpf40a Cdc40 Pcbp2 Snrpf Ubb Pcbp1 Ubc Snrpg Snrpb Hnrnpr Hnrnpu Rbm10 Sugp1 Hnrnpc Snrpd1 Hnrnpd Hnrnpf Hnrnpk Hnrnpl Dhx15 Srsf19 Snrpd3 Srsf11 Srsf12 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-RNO-8986944.1 Transcriptional Regulation by MECP2 Sin3a Hdac2 Lbr Hdac1 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 96%10223181 Axonal growth stimulation Ngfr Ngf Arhgdia Rhoa ER-PHAGOSOME PATHWAY%REACTOME%R-RNO-1236974.1 ER-Phagosome pathway Psmb6 RT1-M1-5 Psmb3 Vamp8 Rt1-ec3 Psme2 Psme1 Psma7 Psmb9 Psmb10 Psmb8 RT1-M6-2 Vamp3 AABR07044308.1 Pdia3 B2m Psmb6l1 RT1-M10-ps1 RT1-M10-ps5 Snap23 Psma4 RT1-N3 Psma3 Psma6 RT1-M5 Psma5 Psma2 Psma1 RT1-M2 RT1-M1-2 Psmb4 Psmb7 CALMODULIN INDUCED EVENTS%REACTOME%R-RNO-111933.1 Calmodulin induced events Adcy5 Adcy6 Adcy9 Prkaca Prkacb Prkcg Prkcd Prkca Camk4 Prkar1a Prkar1b Calm3 Grk2 Prkar2a Prkar2b Pde1b Pde1c Pde1a Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME DATABASE ID RELEASE 96%10223191 NRAGE signals death through JNK Arhgef7 Tiam1 Mcf2l Tiam2 Rac1 Bcl2l11 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Ngef Arhgef19 Vav3 Akap13 Vav1 Vav2 Sos1 Itsn1 Arhgef26 Arhgef25 Sos2 Kalrn Mapk8 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Plekhg5 Plekhg2 Net1 Arhgef10l Rasgrf2 Mcf2 SELENOAMINO ACID METABOLISM%REACTOME%R-RNO-2408522.1 Selenoamino acid metabolism Txnrd1 Scly Sephs2 Mat1a COHESIN LOADING ONTO CHROMATIN%REACTOME%R-RNO-2470946.1 Cohesin Loading onto Chromatin Smc3 Stag2 Stag1 Wapl Pds5b Pds5a Nipbl Mau2 Smc1a LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-RNO-140534.1 Ligand-dependent caspase activation Casp8 Traf2 Tradd Cflar Ripk1 Tnfsf10 Fas Fadd Faslg Ly96 Ticam2 Ticam1 Cd14 Tlr4 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222011 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Pfkfb1 Pfkfb4 Pfkfb3 Pfkfb2 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-RNO-1606322.1 ZBP1(DAI) mediated induction of type I IFNs Ikbkg Nfkbib Nfkb2 Nfkb1 Irf3 Nfkbia Rela Dhx9 Nkiras1 Chuk Myd88 Ikbkb Nkiras2 RHOF GTPASE CYCLE%REACTOME%R-RNO-9035034.1 RHOF GTPase cycle Rhof Akap12 Arhgap12 Myo9b Srgap2 Vamp3 Arhgap5 Syde1 Farp1 Sowahc Arhgap1 Actg1 AABR07021573.2 Actn1 Rab7a Mcam Basp1 Snap23 Arhgap32 Cav1 Mtmr1 Fam169a Slc4a7 Pik3r1 Baiap2l2 Baiap2l1 Diaph3 Add3 Diaph1 Pik3r2 Tor1aip1 Steap3 Lmnb1 Depdc1b Senp1 Esyt1 Arhgap21 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 96%10223933 Activation of kainate receptors upon glutamate binding Grik5 Grik2 Grik1 Grik4 Calm3 Grik3 Ncald Dlg1 Dlg3 Dlg4 MRNA POLYADENYLATION%REACTOME%R-RNO-9770562.1 mRNA Polyadenylation Ppp1ca Srrm2 Snrpepl2 Hnrnph2 Hnrnph1 Papolg Ppp1r8 Rbm25l1 Prr3 Ybx1 Dnajc8 Rbm25 Rbm5 Rbm17 Ddx46 Ddx42 Pcf11 Fip1l1 Cstf1 Rbmx Papola Nudt21 Polr2c Tra2b Cstf2 Polr2a Cstf3 Polr2b Polr2g Cstf2t Polr2h Sympk Polr2e Polr2f Pabpn1 Clp1 Cpsf4 Polr2i Cpsf6 Cpsf7 Polr2j Cpsf1 Cpsf2 Ncbp2 Cpsf3 Ncbp1 Gtf2f2 Gtf2f1 Ppp1cb Phf5a Hnrnpr-ps2 U2surp Snrpa1 Ptbp1 Tut1 Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b3 Sf3b4 Sf3b5 Hnrnpa2b1 Srrt Snrnp70 Htatsf1 Snrpa Snrpc Snrpn Cherp Fus Rps27a Srsf1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Hnrnpa3 Puf60 U2af1 Uba52 Hnrnpa1 Rbbp6 U2af1l4 Tcerg1 Smndc1 Dhx9 Prpf40a Cdc40 Pcbp2 Snrpf Ubb Pcbp1 Ubc Snrpg Snrpb Hnrnpr Hnrnpu Rbm10 Sugp1 Hnrnpc Snrpd1 Hnrnpd Hnrnpf Hnrnpk Hnrnpl Dhx15 Srsf19 Snrpd3 Srsf11 Srsf12 SELECTIVE AUTOPHAGY%REACTOME%R-RNO-9663891.1 Selective autophagy Map1lc3b Csnk2a2 Csnk2a1 Ube2d3 Ube2d2 Park7 Csnk2b Tomm20 Sqstm1 Src Prkn Optn Rps27a Usp30 Ube2l3 Ulk1 Pex5 Dync1h1 Ube2n Uba52 Dync1i2 Dync1i1 Ubb Ubc Mfn1 Mfn2 Tomm22 Atg5 Tbk1 Atg12 Vdac2 Atg9a Pcnt Vdac3 Atm Pgam5 Vdac1 Dync1li2 Tomm40 Dync1li1 Tomm70 Arl13b Dynll1 Mterf3 Dynll2 Map1lc3a Pink1 Fundc1 Tomm7 Nbr1 Cftr SYNTHESIS OF DNA%REACTOME%R-RNO-69239.1 Synthesis of DNA Gins2 Gins1 Gins4 Gins3 Dna2 Lig1 Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Pola1 Pold4 Pold3 Prim2 Prim1 Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Orc4 Cdc26 Orc6 Cdc23 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Gmnn Psmb5 Psmb4 Psmb7 Cdc6 Psmb6 Mcm7 Psmb1 Mcm8 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Anapc5 Pole4 Anapc4 Rpa1 Anapc1 Rpa2 Anapc2 Fzr1 Ubb Rpa3 Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Pole Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Cul1 Cdk2 Cdc16 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%10222677 Immune System Fuca1 Mmtag2 Nbeal2 Prdx4 Plac8 Pgrmc1 Commd9 Retn Lgals3 Ptprn2 Bin2 Cd36 Pa2g4 S100a11 S100a9 Dynlt1 Gmfg Syngr1 Clec4a3 Clec4a2 Glipr1 Man2b1 Tmc6 Clec4b2 Grn Ceacam6 Enpp4 Cgm4 Ypel5 Nfam1 Clec6a-ps1 Aga Commd3 Pigr Pygb Crispld2 Ormdl3 Dnajc13 Lilrc2 Rab44 Adgrg3 Chrnb4 Ear1l1 Epx Kcmf1 Tom1 Serpinb1a Prkcb Rab37 Serpinb12 Serpinb10 Psgb1 Pkp1 Dsc1 Bri3 Gpr84 Ptprb Ghdc Lamp1 Arl8a Rab3d Nit2 Chi3l1 Mospd2 Acp3 Slc2a5 Alad Crisp2 Olfm4 Atad3a Fgl2 Dnase1l1 Hgsnat Mnda Frmpd3 Rnase17 Agpat2 Fcgr3a Mcemp1 Scamp1 Tmem179b Cant1 Unc13d Cpne1 Cpne3 Tmem30a Rnase2 Rnase3 Vat1 Tspan14 Prg3 Anpep Atp6v0b Prg2 Trib3 Bst2 Atp6v0a4 Rap2b Grb10 Rap2c Manba Atp6v1g3 Atp6v0e2 Cap1 Mlec Atp6v1c2 Cd53 Atp6v0a1 Atp6v1c1 Stk11ip Svip Atp6v0c ENSRNOG00000064486 Them4 Qpct ENSRNOG00000064129 Tlr9 Irag2 Cstb Gca Erp44 Atp6v1e2 Creg1 Atp6v1e1 Cd68 Tcirg1 Atp6v1a Dok3 Hebp2 Atp6v1b2 Cd93 Atp6v0d2 ENSRNOG00000067708 Atp6v0d1 Atp6v1b1 Cotl1 Atp6v0e1 Dpp7 Tarm1 Atp6v1g2 Degs1 Atp6v1g1 Atp6v1f Ggh Atp6v1d Cnn2 Psg29 Dnajc5 Ddx3x Cracr2a Clec4a Clec4d Cpped1 Mvp Ms4a3 Pdap1 Kcnab2 Oscar Ap1b1 Tmem63a Cmtm6 Ap1m2 Tnfaip6 Vamp7 Vps35l Ostf1 Ap1m1 Ptx3 Vamp8 Ap1s3 Ap1s2 Txndc5 Ap1g1 Hspa8 Cd180 Ly86 Ptpn4 Tasl Eea1 Lrr1 Nedd4 Tlr10 Irf5 Rnf220 Fbxl21 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb RT1-M6-2 Sh3rf1 Trim11 Ube2l6 Mex3c Cdc34 B2m Dcaf1 Rnf126 Ubac1 Lnpep Atg7 Rnf114 Rnf115 Rnf111 RT1-M10-ps1 RT1-M10-ps5 Snap23 Siah1 Dzip3 Mkrn1 Ube2g2 Ube2g1 Rnf138 RT1-N3 Rnf130 Kbtbd8 Fbxw4 Fbxw5 Fbxw7 Gan Fbxw8 Fbxw9 Anapc13 Det1 Fbxw2 Klhl5 Rbck1 Arih2 Rlim Klhl3 Klhl2 Ube4a Spsb2 RT1-M1-2 Trim9 Spsb1 Trip12 Wwp1 RT1-M1-5 Spsb4 Rt1-ec3 Lrsam1 Eloc Huwe1 Elob Ube2j1 Kctd7 Ube2u Kctd6 Ncf1 Ncf2 Ube2w Ncf4 Ube2m Ube2k Rnf182 Ube2o Ltn1 Pdia3 Ube2b Mgrn1 Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Tap2 Tap1 Fbxo17 Lmo7 Rnf41 Mylip Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Fbxo21 RT1-M5 Fbxo22 Ubox5 Ubr1 Rnf19a Ubr2 Glmn Ubr4 RT1-M2 Fbxo27 Uba5 Uba6 Trim69 Uba7 Fbxw17 Trim71 Klhl25 Ube2e3 Ube2e2 Klhl21 Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Lonrf1 Zbtb16 Hspa5 Uba1 Cyba Cybb Uba3 Cul2 Myo5a Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Pja2 Pja1 Arel1 Trim63 Rnf144b Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Herc6 Fbxo9 Trim21 Vhl Tapbp Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Trim36 Trim32 Trim41 Unkl Erap1 Asb9 Asb7 Asb6 Asb5 Rnf25 Asb4 AABR07044308.1 Rchy1 Asb1 Lnx1 Lpcat1 Clec7a Card9 Gpi Pgam1 Aldoc Aldoa Pfkl Pkml1 Hk3 Hspa1b Hspa1a Kif3a Clec4e Crkl Rapgef1 S100a1 Gsdme Tlr1 Gsdmd Tlr7 Tlr6 Lbp S100a8 Tlr2 Arhgap45 Stom Arhgap9 Pld1 Stk10 Faf2 Diaph1 C1qbp Stbd1 Dock2 Myo9b Racgap1 Rock1 Dhx36 Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Dnajc3 Eif2ak2 Psmb1 Fancl Psmb3 Fancm Psmb2 Myh9 Pim1 Uba52 Fanca Myo10 Fancb Anapc10 Fancc Mapt Ube2d1 Fance Fancf Btrc Fancg Psma7 Nck1 Gbp5 Pde12 Ilf2 Psmc5 Actb Psmc2 Dus2 Psmc1 Ilf3 Psmc4 Flnb Psmc3 Snca Anapc5 Dhx9 Ppm1b Anapc4 Mx2 Arih1 Anapc1 Anapc2 Pggt1b Trim25 Fzr1 Ptpn2 Ubb Hspa1l Anapc7 Gbp2 Ubc Gbp1 Nek2l1 Gbp3 Ube2e1 Faap100 Psmb6l1 Npm1 Psmd7 Casp1 Oasl Psmd6 Hspa2 Psmd8 Faap24 Isg15 Psmd2 Faap20 Psmd1 Adrm1 Cul1 Cdc16 Cdk1 Mapk1 Ppp2cb Ppp2ca Prkaca Prkacb Prkcd Gusb Calm3 Ppp2r5d Il1rap Map3k3 Il1rn Irak4 Irak3 Tollip Il1a Ppp2r1b Il1b Ppp2r1a Il1r2 Il1r1 Nfasc Ctsh Hbb Ckap4 Tp53 H2ab2 H2ac4 Abl1 ENSRNOG00000066901 Ccnd1 Crebbp Kmt2a Kmt2c H2ac18 Csnk2a2 Ctsk Ctsl Csnk2a1 Hist1h2bq Wdr5 Ash2l Csnk2b H2aj Smarca4 H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Itch Ptpn11 H2bc18 H2az2 Rbbp5 H2bc4 Hist1h4m H2bc1 Hist1h2ai Neu1 Glb1 Ctsa Rnf185 Prkaa1 Derl3 Prkaa2 Derl2 Stt3b Rbx1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Tmem258b Tusc3 Cdk4 Cul3 Ezh2 Erlec1 B3gnt3 Dad1 Ywhag Suz12 Ddost Eed Gsk3b Cd274 Os9 Pdcd1 Rnf5 Sel1l Magt1 Rbbp4 Rbbp7 Ppie Mib2 Pdcd1lg2 Prkab2 Prkab1 Ybx1 Creb1 Sptbn2 Ptk2 Mapk3 Sptan1 Ddx41 Rps6ka5 Nras Tnfsf13 Grb2 Fyn Kras Sos1 Hras Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Slc15a4 Mapk7 Nkiras2 Iqgap2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Tnf Fos Vrk3 Tnfrsf1a Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Ptges2 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Usp14 Tab3 Tab2 Cep290 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Tubb5 Itgav Tubb4b Furin Cdk13 Itgb1 Kif26a Rbsn Kif11 Kif15 Kif5a Kif5b Akt3 Akt2 Akt1 Optn Rab31 Kif22 Kif23 Kif20a Klc1 Kifap3 Klc4 Klc3 Klc2 Kif3b Kif3c Sh2b1 Rab3a Stxbp2 Cxadr Plcg2 Gdi2 Rab7a Prkce Cfd A1bg Rab27a Prkg1 Hrg Olr1 Tbc1d10c Pik3r6 Trappc1 Rab6a Ceacam1 Rab5c Ahsg Rab5b Stx4 Serpina3n F12 Serpinb6a Rab9b Jaml Rab10 Rab14 Rab18 Anxa2 Qsox1 Itga4 Lamp2 Pnp Ampd3 Cd177 Itpr3 Itpr2 Itpr1 Aprt Lyn Yes1 Src Rhoa Lrrc7 Itgal Camk2g Camk2d Camk2b Itgb2 Lcp2 Camk2a Zap70 RT1-Db2 Cd3g P2rx1 Cd247 RT1-Db1 Cd3e Cd3d Aamp Trav19 Trem1 AC109737.1 Cd4 RT1-Ha Mif Lck Ptpn22 RT1-Ba RT1-Bb ENSRNOG00000065955 Trbv16 RT1-Da Ifng Ifngr2 Ifngr1 Raf1 Jak2 Orm1 Rhog Rac2 Ano6 Atp6ap2 Cd47 Ctsd Mme Ctsg Cd63 Ctsz Cd74 Prtn3 Cpb2 Ppia Aim2 Fcer1g Psme2 Psme1 Psmb9 Psmb10 Psmb8 Sell Sirpa Plau Pecam1 Nos1 Inpp5d Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Csf2rb Csf1 Pik3r1 Pik3cb Csf2 Jak3 Pik3r2 Pik3r3 Inppl1 Pik3cd Fuca2 Pik3r5 Pik3cg Irs2 Bpifb2 Alox5 Lta4h Cst3 Sec13 Hpse Csf3 Nckap1l Wipf3 Wipf1 Sar1b P4hb Apob Abi2 Abi1 Arpc3 Arpc2 Arpc5 Arpc4 Brk1 Dsp Dsg1 C3ar1 Wasf3 Wasf2 Wasf1 Arpc1b Actr2 Arpc1a Ppbp Fpr1 Actr3 Btk Fpr2 C3 Nckap1 C5 Cyfip2 Cyfip1 Rhof Nckipsd Pld2 Elmo2 Baiap2 Ccr6 Limk1 F2 Pdxk Bst1 Vnn1 Ptafr Naprt Slc2a3 Cyb5r3 Cd55 Cxcr1 Cxcr2 Folr2 Ghr Gh1 Prl Prlr C5ar2 C5ar1 Atp7a Defb41 Defb42 Np4 Defb43 Defb44 Kng1 Defa24 Svs3b Ear1 Bpifb1 Bpifb6 Bpifb4 Defal1 Pglyrp1 Pglyrp2 Reg3a Reg3b Pglyrp3 Pglyrp4 Defa31 Stath Reg3g Bpi Defa Camp Chga Ltf Lyz1 Bpifa1 Bpifa2 Defb14 Defb17 Defb18 Art1 Defb21 Defb5 Rnase6 Defb24 Defb1 Slc11a1 Defb25 Eppin Defb28 Defa9 Defa8 Defb30 Defa6 Defa3 Itln1 Lcn2 Atox1 Malt1 Bcl10 Nfkbie Rel Psap Pias1 Adgre5 Cxcl1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Pik3ap1 Fcgr2 Cd28 Syk Icos Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Fgr ENSRNOG00000065564 Frk Rictor Hck Cd86 ENSRNOG00000066971 Cd80 ENSRNOG00000063341 Prr5 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 Il1rl1 Trat1 ENSRNOG00000063148 Igkvl13 Casp9 AABR07065812.2 Mapkap1 ENSRNOG00000063707 Madcam1 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 Itgb7 ENSRNOG00000064481 Icam1 ENSRNOG00000065690 ENSRNOG00000064085 Icam5 ENSRNOG00000066904 Icam4 ENSRNOG00000063713 Icam2 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 Vcam1 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Hvcn1 Prkcq Rasgrp1 Cfp Rap1a Rap1b Tyk2 Bcl2l1 Kbtbd7 Il6st Ppp2r5b Ppp2r5a Golga7 Brwd1 Tslp Il7 Il7r Ppp2r5e Btla Irs1 Fcer1a Txk Ppp3ca Ppp3cb Itk Nfatc1 Nfatc3 Nfatc2 Ppp3r1 Grap2 Lamtor3 Ms4a2 Lamtor2 Tec Vcl Il6 Ist1 Il6r Fnta Fntb Lat Flt3 Ywhab Fgb Fga Fgg Csk Pld4 Mapk12 Il1rapl1 Nme2 Slc44a2 Fkbp1a Mtor Cab39 Lamtor1 Mlst8 Mgst1 Gstp1 Pak1 Pak2 Apeh Mre11 Ube2v2 Trpc1 Stim1 Xrcc6 Xrcc5 Herc2 Sumo1 Unc93b1 Lgmn Tlr8 Cnpy3 Padi2 Sfn Kif18a Dync1h1 Dync1i2 Dync1i1 Cenpe Arg1 Kif2a Kif2b Kif2c Dync1li2 Dync1li1 Aoc1 Dynll1 Dynll2 Ywhaz Pdpk1 ENSRNOG00000070986 Lat2 Ctnnb1 Cd101 Pag1 Ptprc Fyb1 Smurf2 Ctsb Cbll1 Ctss Dnm2 Jup Impdh2 Pycard Panx1 Impdh1 Txnip Sugt1 Nlrp3 Txn Mefv Pstpip1 Nlrp1a Hsp90ab1 P2rx7 Tbk1 Irf3 Mavs Rig1 Tax1bp1 Ikbke Cyld Gns Galns Hexb H2az1 Krt1 Prcp Plcg1 Pla2g2a Sdcbp Rac1 Pak3 Hsp90aa1 Sphk1 Srp14 Foxo3 Mmp9 Fkbp5 Nos3 Fabp5 Il12rb1 Il12rb2 Ebi3 Il12b Il27 Il23a Actr1a Il12a Crlf1 Il23r Dctn1 Dctn2 Icoslg Dctn4 Sec23a Ctsc Arf1 Copb1 Sec31a Serpina1 Actr10 Sec24d Sec24c Sec24b Sec24a Cd59 Idh1 Adar Socs1 Il13ra2 Il4r Stat6 Il13 Hsp90b1 Socs5 Il4 Stat3 Stat1 Actg1 Sqstm1 Vav3 Vav1 Vav2 Psen1 Sos2 Ncstn Myo1c Casp3 Casp2 Myd88 Ap2m1 Clta Cltc Dnm1 Socs3 Cbl Cdc42 Slco4c1 Ube2d3 Ube2d2 Acaa1b Stx1a Slc27a2 Sting1 Mapk13 Vamp2 Eda Tnfrsf4 Tnfrsf8 Tnfrsf1b Edar Tnfrsf11b Tnfrsf11a Cd40lg Tnfsf4 Cd40 Tnfsf13b Tnfsf11 Cat Tnfsf8 Tnfsf9 Relb Tnfrsf9 Lta Ltb Tnfrsf17 Edaradd Tnfsf15 Tnfsf14 Vapa Tnfsf12 Tnfrsf13c Tnfsf18 Ltbr Tnfrsf25 Nos2 Eda2r Tnfrsf18 Tnfrsf12a Map3k14 Ube2j2 Kpnb1 Kpna1 Armc8 Kif4b Ap2s1 Kif4a Dnm3 Ap2a2 Ap2a1 Ap2b1 Ifi44 Sh3gl2 Ifi44l Osbpl1a Chit1 Fcn2 Fcn1 Cr2 Serping1 Cr1l Clu Mbl2 Cd81 Snap29 Masp1 Masp2 C4b C1qb Crp C1qa Cfh Cfi C2 Elane C4 Hp Colec10 C6 C9 Cd46 Cfhr1 C1s C1r Cpn1 Cpn2 Cd19 C1qc Sh3kbp1 Fth1-ps5 Pik3c3 Pafah1b2 Fth1 Pik3r4 Prkra Tarbp2 Ftl1 Itgax Pla2g6 Crk Igf2r Vamp3 Nlrp4 Dtx4 Gsn Sh3glb2 Plpp4 Plpp5 Pld3 Eef2 Il34 Ptprz1 Il16 Txlna Csf1r Stx3 Calr Arsa Lpo Mpo Asah1 Gm2a Il18 Gla Arsb Nectin2 Pvr Rab4b Cand1 Rnf19b Hace1 Birc2 Canx Npc2 Plaur Trpm2 Atp11b Atp11a Atp8b4 Smurf1 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 Hmox2 Cd207 Mrc2 Mrc1 Ripk3 Prkn Stub1 Ripk1 Capza1 Capza2 Fadd Il1rl2 Il1f10 Ube2l3 Dapp1 Cd22 Blnk Ttr Cd79a Cd79b Il36a Il36rn Il36g Il18rap Il18r1 Il18bp Dgat1 Sdc1 Elmo1 Ptpn1 Rapgef4 Rapgef3 Rasgrp2 Btn1a1 Btnl9 Btn2a2 Cd209a Btnl2 Ppl Xdh Mmp25 Adam10 Adam8 Mmp8 Try10 Prss2l1 Tyrobp Klkb1 Trem2 Try5 Cd44 LOC102554637 Capn1 Timp2 Prss2 Acly Prss3 Prss1 A2m Eef1a1 Cntf Cntfr Ifnlr1 Clcf1 Ctf1 Il20rb Il20ra Il31ra Lif Il10 Il11 Il22ra2 Osmr Il10rb Il10ra Il22 Il11ra1 Il20 Il24 Osm Il22ra1 Lifr Ifnl1 Ifnl3 Becn1 Tomm70 Rnf123 Dera Pgm2 Siah2 Keap1 Clec5a Siglec15 Siglec10 Klrd1 Klrc2 Klrk1 Klrc1 Apaf1 Il33 Cda Ndufc2 Pten Aldh3b1 Snap25 Tirap Actr1b Siglec1 Siglec5 Siglec8 LOC100910497 Slamf6 Slamf7 Hcst Kir3dl1 Pilrb2l4 Ctla4 Cct2 Ifitm1 Ifitm2 Ifitm6 Pilrb1l3 Rap1gap Lag3 Pilrb-ps7 Cd160 ENSRNOG00000070312 Pianp Cd226 Ifitm3-ps2 LOC134481331 Ifi30 Lair1 Rilp Treml2 Treml4 Cd200 Ctse Cct8 Ctsf Cd1d Ctso ifitm3 Cd34 Sipa1 Cd200r1l LOC120093164 Il15 Rap1gap2 Il15ra Cd96 Il9 Il21 RT1-DOa RT1-DOb Ptk2b Stat5a Crtam Stat5b Cd8b Cd8a Il9r Cd300le Cd300ld RT1-DMb Cd300lg Cd300lf Klrb1a Clec4g Clec2e Ifnar1 LOC120103158 Gaa LOC120103159 Ifnar2 Agl Ifnb1 Pygl Rnasel Ifna4 Ifna1 Ifna1l1 Ifna4l1 Irf9 Gyg1 Pgm1 Prdx6 ATTENUATION PHASE%REACTOME%R-RNO-3371568.1 Attenuation phase Hsbp1 Fkbp4 Hspa2 Hsp90ab1 Ptges3 Crebbp Hspa8 Ep300 Hsp90aa1 Hsf1 Hspa1b Hspa1a Dnajb1 Hspa1l PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 96%10223539 Proton-coupled monocarboxylate transport Slc16a8 Slc16a1 Bsg Emb Slc16a7 Slc16a3 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 96%10224917 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Rabggta Rabggtb Chm AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME DATABASE ID RELEASE 96%10222321 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Cyp1a2 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-RNO-1963640.1 GRB2 events in ERBB2 signaling Grb2 Erbb2 Kras Sos1 Ereg Hras Nrg2 Nrg3 Hbegf Btc Nras DSCAM INTERACTIONS%REACTOME%R-RNO-376172.1 DSCAM interactions Dscaml1 Dscam TRANSLESION SYNTHESIS BY REV1%REACTOME%R-RNO-110312.1 Translesion synthesis by REV1 Rev1 Rev3l Rfc5 Uba52 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Rps27a Rpa1 Rpa2 Ubb Rpa3 Ubc Mad2l2 CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-RNO-110331.1 Cleavage of the damaged purine Acd Terf1 Hist1h2ai Mpg Ogg1 H2aj Terf2ip Mutyh Tinf2 H2ab2 Pot1 Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Hist1h4m Terf2 H2bc1 Neil3 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-RNO-6806667.1 Metabolism of fat-soluble vitamins Akr1c18 Akr1c12l1 Akr1c19 Akr1c21 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Akr1c9 Apoc2 Apoa1 Apoc3 Apoa2 Apoe Apoa4 Apob Lrp1 Sdc4 Sdc3 Sdc2 Lpl Gpihbp1 Lrp8 Lrp2 Lrp10 Plb1 Lrp12 Ubiad1 Ttr Gpc1 Vkorc1 Ttpa Rdh11 Gpc3 Vkorc1l1 Gpc2 Gpc5 Gpc4 Bco2 Bco1 Gpc6 Clps Pnlip Akr1b10 Rbp4 Apom Rbp2 Rbp1 Sdc1 Lrat Agrn ASPIRIN ADME%REACTOME%R-RNO-9749641.1 Aspirin ADME Slco2b1 Cyp3a9 Glyatl3 Acsm2 Acsm4 Acsm5 Abcc2 Ugt1a2 Glyat Ugt1a1 Ugt1a3 Abcc3 Ugt1a5 Cyp3a18 Cyp2c66 Cyp2e1 Ugt2b1 Cyp2c11 Ugt1a6 Slc22a7 Ugt1a7 Ugt1a8 Ugt2b7 Cyp3a1 AC114845.1 Cyp2d4 Ugt2b34l1 Cyp3a62 Ugt2b Ugt2a1 Cyp3a2 Ugt2a3 Ces2h Alb Ugt2b17 Ugt2b37 Ugt2b15 Ugt3a1 Bche Slc16a1 Bsg Ces1d GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-RNO-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins Fgb Apbb1ip Fga Fgg Itga2b Ptk2 Src Tln1 Grb2 Rap1a Rap1b Sos1 Fn1 Itgb3 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 96%10224943 PI5P Regulates TP53 Acetylation Pip4k2b Pip4k2c Pip4p1 Pip4k2a Map2k6 Ep300 Ing2 Tp53 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME%R-RNO-1810476.1 RIP-mediated NFkB activation via ZBP1 Ikbkg Nfkbib Dhx9 Nkiras1 Nfkb2 Nfkb1 Chuk Myd88 Ikbkb Nfkbia Nkiras2 Rela BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-RNO-9027307.1 Biosynthesis of maresin-like SPMs Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a9 Cyp3a62 Cyp3a2 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-RNO-168928.1 DDX58 IFIH1-mediated induction of interferon-alpha beta Ikbkg Uba52 Nfkb2 Nfkb1 Crebbp Rela S100b Ubb Hmgb1-ps34 Ubc Nfkbib Hsp90ab1 Tbk1 Irf3 Mavs Rig1 Tax1bp1 Ager Ikbke Nfkbia Ep300 Hmgb1l2 Cyld Hmgb1l1 Hsp90aa1 Nlrx1 Tomm70 Rps27a Nkiras1 App Chuk Ikbkb Irf7 Nkiras2 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%10222019 Phase II - Conjugation of compounds Tpst1 Mtr Gsta5 Tpst2 Gsta6 Sult2b1 Gsta3 Gsta1 Sult1a1 Sult1c2 Gsta2 Sult1b1 Chac1 Bpnt2 Glyatl3 Chac2 Sult6b1 Gstm7 Acsm2 Sult4a1 Gstm5 Acsm4 Gstk1 Sult2a2 Acsm5 Bpnt1 Ugt1a2 Ggct Glyat Ugt1a1 Sult2a1 Ugt1a3 Gstm1 Sult2a6 Ugt1a5 Gclc Abhd14b Gstm2 Mgst3 Podxl2 Ugt2b1 Gsto2 Esd Cndp2 Mgst2 Ugt2b7 Mgst1 AC114845.1 Ugt2b34l1 Gclm Ggt1 Ugt2b Ggt5 Ggt7 Ggt6 Hpgds Gstm4 Gss Gstp1 Ugt2b17 Gstt2 Ugt2b37 Akr1a1 Ugt2b15 Gstt1 Mat1a Oplah Abhd10 Ugt1a6 Ugt1a7 Slc35d1 Ugt1a8 Cyp1a2 Nat1 Nat2 Nat3 Ugt2a1 Ugt2a3 Ugt3a1 As3mt Ahcy Comt Mtrr Uxs1 Gsto1 Ugp2 Tpmt Ugdh Mat2a Gstz1 Mat2b Sult1e1 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-RNO-9032500.1 Activated NTRK2 signals through FYN Fyn Dock3 Bdnf Rac1 Ntrk2 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 96%10225319 Cellular response to starvation Atp6v0b Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v1c1 Atp6v0c Atp6v1e2 Sesn2 Atp6v1e1 Tcirg1 Sesn1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Nprl3 Nprl2 Wdr59 Mios Depdc5 Wdr24 Lamtor3 Fnip1 Lamtor2 Fnip2 Samtor Rptor RragB Itfg2 Castor2 Castor1 Mtor Sec13 Rheb Szt2 Slc38a9 Lamtor5 Lamtor4 Kics2 Rraga Flcn Lamtor1 Rragc Sh3bp4 Rragd Mlst8 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-RNO-1614558.1 Degradation of cysteine and homocysteine Slc25a10 Cth Mpst Usf1 Sqor Ethe1 Fmo1 Suox Ado Txn2 Tst Gadl1 Cdo1 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-RNO-6814122.1 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding Csnk2b Rgs7 Pdcl Tcp1 Cct6b Cct7 Cct6a Gnb2 Gnb1 Gnb4 Cct8 Gnb3 Cct5 Gnb5 Cct4 Csnk2a2 Csnk2a1 Cct3 Cct2 Rgs9 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 96%10225521 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) Arhgef4 Tiam1 Uba52 Rac1 Farp2 Ctnnb1 Ctsb Src Cbll1 Ctss Cdh1 Ctnna1 Rps27a Ctsl Vav2 Jup Ctnnd1 Cdc42 Ubb Ubc REPRODUCTION%REACTOME%R-RNO-1474165.1 Reproduction Izumo1 Cd9 Hyal5 Rad51 Catsperg Catsperd Catsper4 Catsper2 Catsperb Hvcn1 Catsper3 Fignl1 Catsper1 Kcnu1 Acr Dmc1 Firrm Izumo4 Izumo3 Izumo2 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222809 Lectin pathway of complement activation Fcn2 Fcn1 Colec10 Mbl2 Masp1 Masp2 SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 96%10224345 Signaling by NOTCH1 Itch Rps27a Dtx4 Uba52 Ubb Ubc Dtx2 NTRK2 ACTIVATES RAC1%REACTOME%R-RNO-9032759.1 NTRK2 activates RAC1 Fyn Dock3 Bdnf Rac1 Ntrk2 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%10222651 Polo-like kinase mediated events Foxm1 Pkmyt1 Plk1 Wee1 Cdc25c FRUCTOSE BIOSYNTHESIS%REACTOME%R-RNO-5652227.1 Fructose biosynthesis Sord Akr1b1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME DATABASE ID RELEASE 96%10222109 Detoxification of Reactive Oxygen Species Cat Ncf1 Ncf2 Prdx3 Ncf4 Cyba Prdx6 Cybb Nox4 Prdx2 Prdx5 Gpx3 Gpx6 Gstp1 Gpx5 Gpx8 Gpx7 Txn Prdx1 Sod1 Txnrd1 Cycsl2 Nudt2 Ero1a Gsr Txnrd2 P4hb Sod3 Ccs Txn2 Cycs Gpx2 Sod2 Gpx1 RAB GERANYLGERANYLATION%REACTOME%R-RNO-8873719.1 RAB geranylgeranylation Rab43 Rab21 Chml Rab9a Rab9b Rab1A Rab10 Rab13 Rab12 Rab2b Rab14 Rab34 Rab18 Rab20 Rab8b Ptp4a2 Rab8a Rab23 Rab26 Rab25 Rab29 Rab40b Rab15 Rab17 Rab19 Rab3c Rab3b Rab36 Rab11b Rab11a Rab31 Rab35 Rab38 Rabggta Rabggtb Rab1b Rab5a Rab4a Rab33b Rab33a Rab3a Chm Rab7a Rab7b Rab44 Rab27a Rab39a Rab27b Rab2a Rab37 Rab4b Rab3d Rab6b Rab6a Rab5c Rab5b FRS2-MEDIATED ACTIVATION%REACTOME%R-RNO-170968.1 Frs2-mediated activation Map2k1 Mapk1 Rap1a Braf Ntrk1 Frs2 Ngf Mapk3 Crkl Ywhab Rapgef1 Map2k2 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 96%10222343 Beta oxidation of palmitoyl-CoA to myristoyl-CoA Acadvl Hadha Hadhb METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 96%10222721 Metabolism of vitamin K Ubiad1 Vkorc1 Vkorc1l1 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-RNO-9948299.1 Ribosome-associated quality control LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Ube2d3 Rplp1 Ube2d2 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Rpl23a Eloc Elob Ltn1 Trip4 Cul2 Pelo Tcf25 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Rps14 Psmd14 Rps15 Psmd13 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Rpsa Psmb5 Rpl35 Rps10 Psmb4 Rps11 Psmb7 Rpl36 Rps13 Psmb6 Rpl37 Rps4x-ps13 Rpl38 Rps3a Psmb1 Rpl39 Rps27l Psmb3 Rpl8 Rps9 Psmb2 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Ube2d1 Rpl7 Rps26-ps13 Psma7 Rpl30 LOC134486107 Rpl31 Rpl32 Psmc5 Psmc2 Rpl34 Psmc1 Rpl36al1 Psmc4 Psmc3 Rpl39l1 Rchy1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Ubb Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Psmb6l1 Rps24 Ascc3 Rpl23 Ascc2 Psmd7 Nemf Psmd6 Fau Zfp598 Psmd8 Psmd2 LOC120097744 Psmd1 Adrm1 Rbx1 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Klhdc10 Rps6 Hbs1l LOC100910714 OAS ANTIVIRAL RESPONSE%REACTOME%R-RNO-8983711.1 OAS antiviral response Oasl Rig1 Rnasel Pde12 CELLULAR SENESCENCE%REACTOME%R-RNO-2559583.1 Cellular Senescence Suz12 Eed Ep400 Asf1a Cabin1 Rbbp4 Hira Rbbp7 Ubn1 Hmga2 Hmga1 Map3k5 Tnik Mink1 Map4k4 Mapk3 Mapk9 Mapk7 Mapk8 Mre11 Kat5 Nbn Fos Rps6ka3 Rps6ka1 Rps6ka2 Map2k7 Map2k6 Tp53 Txn Mapkapk3 Mapk14 H2ab2 Jun Mapkapk2 Atm H2ac4 H1-1 H1-0 Map2k3 H1-5 H1-4 H4f3 Ring1 Mapk10 Mapk11 ENSRNOG00000066901 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Rad50 Ehmt1 Cdk6 Kdm6b H2ac18 Bmi1 Hist1h2bq Terf2 Acd Terf1 H2aj Terf2ip Tinf2 Pot1 Ccna1 H3-3b Ccna2 Ube2s Hist3h2ba Rnf2 ENSRNOG00000068602 Ccne1 Rps27a Ccne2 Ube2c Cdkn2b Lmnb1 Cdkn2d Cdc27 H2bc18 Cdc26 Cdc23 H2az2 H2bc4 Hist1h4m H2bc1 Hist1h2ai Uba52 Anapc10 Ube2d1 Anapc16 Anapc15 Anapc5 Anapc4 Anapc1 Erf Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Cebpb Cdkn1b Rb1 Id1 Ets1 Ets2 Cdk2 Cdc16 Mapk1 Mdm4 Cdk4 Mapkapk5 Ezh2 FLT3 SIGNALING%REACTOME%R-RNO-9607240.1 FLT3 Signaling Pik3ca Gab2 Akt3 Akt2 Akt1 Pik3r1 Nras Grb2 Kras Sos1 Hras Grb10 Flt3 Foxo3 PROTEIN METHYLATION%REACTOME%R-RNO-8876725.1 Protein methylation Kin Mettl21a Eef2kmt Eef1akmt2 Camkmt Eef1akmt1 Hspa8 Eef1a1 Eef2 Calm3 Prmt3 Rps2 Etfb Mettl22 Etfbkmt CHAHP COMPLEX ASSEMBLY%REACTOME%R-RNO-9940465.1 ChAHP complex assembly Chd4 Cbx3 Adnp Cbx1 DAP12 SIGNALING%REACTOME%R-RNO-2424491.1 DAP12 signaling Klrd1 Klrc2 Klrk1 Klrc1 Tyrobp Syk Plcg1 Trem2 B2m Lck Plcg2 Grap2 Pik3ca Shc1 Rac1 Pik3r1 Pik3cb Nras Vav3 Grb2 Pik3r2 Fyn Btk Kras Vav2 Sos1 Hras Lat Lcp2 KINESINS%REACTOME DATABASE ID RELEASE 96%10224083 Kinesins Klc1 Kif20b Kifap3 Klc4 Klc3 Klc2 Kif3b Kif3c Racgap1 Kif18b Kif19 Kif26b Kifc1 Kifc2 Kif3a Kif26a Kif11 Cenpe Kif12 Kif15 Kif5a Kif5b Kif21a Kif1c Kif2a Kif2b Kif21b Kif2c Kif13b Kif1a Kif4b Kif1b Kif6 Kif4a Kif9 Kif22 Kif23 Kif28 Kif27 Kif16b Kif18a Kif20a REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 96%10223385 Regulation of thyroid hormone activity Dio1 Dio2 Dio3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 96%10222825 Toll Like Receptor 7 8 (TLR7 8) Cascade Ppp2cb Ppp2ca Tasl Irf5 Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Slc15a4 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Tlr7 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Ly96 Mapk11 Ticam2 Irf7 Ticam1 Cd14 Tlr4 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-RNO-430039.1 mRNA decay by 5' to 3' exoribonuclease Dcp1b Dcp2 Lsm3 Patl1 Lsm5 Edc3 Edc4 Lsm1 Lsm6 Ddx6 Lsm7 Dcp1a FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223099 FGFR1 ligand binding and activation Fgf17 Tgfbr3 Gipc1 Fgf10 Fgf2 Fgf1 Fgf20 Fgf4 Kl Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgfr1 Fgf9 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 96%10222849 Toll Like Receptor 3 (TLR3) Cascade Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Rps6ka1 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Irf3 Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Irf7 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 96%10222821 MyD88 dependent cascade initiated on endosome Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Ly96 Mapk11 Ticam2 Irf7 Ticam1 Cd14 Tlr4 RHO GTPASES ACTIVATE PKNS%REACTOME%R-RNO-5625740.1 RHO GTPases activate PKNs Ywhag Rhoc Ppp1r12a Hist1h2ai Ncoa2 Ppp1r14a Pdpk1 Ppp1cb H2ac18 Hist1h2bq Pkn2 Pkn1 Ywhae H2aj Kdm4c Rac1 H2ab2 Rhob Cdc25c H3-3b Hist3h2ba H2ac4 Rhoa ENSRNOG00000068602 H2bc18 Ywhaq Ywhah ENSRNOG00000066901 H2az2 Ar Sfn Ywhab H2bc4 Hist1h4m Kdm1a H2bc1 Ppp1r12b Ywhaz NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 96%10222163 Nucleotide salvage Gmpr2 Pnp Ampd3 Ampd2 Ampd1 Adk Tymp Gmpr Hprt1 Dck Upp1 Aprt Upp2 Ada Cda Pudp Tk2 Uck1 Uck2 Dguok TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME DATABASE ID RELEASE 96%10222831 Toll Like Receptor 2 (TLR2) Cascade Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Tirap Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 96%10223507 Chemokine receptors bind chemokines Cxcl9 Ccl7 Ccl5 Ccl4 Ccrl2 Cxcr1 Ccl3 Cxcr2 Ccl1 Xcr1 Cxcr3 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Cxcr4 Cxcr5 Cxcl16 Ackr3 Cxcl13 Ackr4 Ccl19 Ccl17 Ackr2 Ccl11 Ccl12 Cxcl11 Cxcl12 Pf4 Cx3cl1 Cxcl10 Ccr9 Ccr8 Ccr7 Ccr6 Cx3cr1 Ccr5 Ccl27 Ccr4 Ppbp Ccr3 Xcl1 Ccl20 Ccr10 Ccl21 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME DATABASE ID RELEASE 96%10222631 Amplification of signal from the kinetochores Spdl1 Nup133 Bub1 Ppp2cb Itgb3bp Ppp2ca Zwilch Ppp2r5d Ppp2r1b Ppp2r1a Pafah1b1 Zw10 Knl1 Ska2 Ska1 Zwint Cdc20 Rps27 Rcc2 Kif18a Nudc Ppp2r5b Dync1h1 Ppp2r5a Spc24 Spc25 Xpo1 Nuf2 Mad2l1 Cdca8 Incenp Dync1i2 Bub1b Ndel1 Ppp1cc Dync1i1 Cenpc Cenpa Aurkb B9d2 Ppp2r5e Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Plk1 Sgo2 Sgo1 Nup107 Kif2a Sec13 Kif2b Kif2c Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ranbp2 Ckap5 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%10223589 ATF6 (ATF6-alpha) activates chaperones Atf6 Mbtps1 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%10222507 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Pdpk1 Prkaca Prkacb Gna11 Rictor Prkar1a Prr5 Prkar1b Calm3 Adm Gng3 Mapkap1 P2ry2 Gng5 Pkn2 Gng4 Gnaq Gng7 Capn2 Gng8 Gngt1 Vcl Prkar2a Prkar2b Mtor Capns1 Akt1 Gnb2 Gnb1 Gnb4 Gnb3 Nos3 Gnb5 Trpv4 Ramp2 Gng11 Gng10-ps1 Gnas Mlst8 Calcrl DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%10221963 DNA Damage Telomere Stress Induced Senescence Hist1h2ai Mre11 Kat5 Ep400 Rad50 Nbn Asf1a Cabin1 Hira Ubn1 H2ac18 Hmga2 Hmga1 Hist1h2bq Terf2 Tp53 Acd Terf1 Cdkn1b Rb1 H2aj Terf2ip Tinf2 H2ab2 Pot1 Ccna1 Ccna2 Hist3h2ba Cdk2 Atm H2ac4 ENSRNOG00000068602 H1-1 H1-0 Ccne1 H1-5 Ccne2 H1-4 H4f3 Lmnb1 ENSRNOG00000066901 H2az2 H2bc4 Hist1h4m H2bc1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME DATABASE ID RELEASE 96%10222911 TGF-beta receptor signaling activates SMADs Tgfb2 Tgfb3 Ltbp3 Ltbp2 Tgfbr3 Mtmr4 Uba52 Furin Ltbp4 Tgfbr1 Tgfbr2 Ltbp1 Strap Bambi Ube2m Itgb8 Itgb6 Nedd8 Itgb1 Itgb3 Ubb Ubc Fkbp1a Smad2 Smad3 Smad4 Smad7 Cbl Stub1 Zfyve9 Rps27a Itga8 Itgav Smurf2 Tgfb1 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-RNO-69601.1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Fbxw11 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Chek1 Psmc3 Chek2 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Mapk14 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cdc25a Mapk11 Skp1 Psmb5 Plk3 Psmb4 Csnk1e Psmb7 COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 96%10222983 Cobalamin (Cbl) metabolism Mtr Mmachc Mmadhc Mmut Mmaa Mtrr Mmab N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 96%10224067 N-glycan antennae elongation in the medial trans-Golgi St8sia6 Mgat4c Mgat4b B4galt2 B4galt3 Chst10 St3gal4 B4galt4 B4galt5 B4galt6 St6gal1 Mgat5 Fut8 Fuca1 Mgat4a Man2a1 Mgat3 St8sia2 Man2a2 St8sia3 Mgat2 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693616.1 Presynaptic phase of homologous DNA pairing and strand exchange Mre11 Xrcc2 Kat5 Rad51 Rad50 Nbn Atm Rad51c Rad51b Exo1 Chek1 Rbbp8 Rmi2 Brca2 Rmi1 Brca1 Blm Brip1 Bard1 Wrn Top3a Dna2 MUSCLE CONTRACTION%REACTOME%R-RNO-397014.1 Muscle contraction Prkaca Tln1 Cacna1c Calm3 Kcna5 Akap9 Kcne5 Kcnq1 Kcne4 Myl12b Kcne3 Pxn Kcne2 Kcnh2 Myl10 Cacnb1 Pde5a Gucy1b1 Itpr3 Cacnb2 Tmod1 Gucy1b2 Itpr2 Tmod4 Itpr1 Pak1 Tmod2 Itga1 Kcnj4 Cacng4 Tnni2 Atp2a1 Lmod1 Tnni1 Cacna2d2 Pak2 Tpm4 Myl4 Kcnj2 Atp2a3 Tpm2 Myl1 Atp2a2 Myl2 Cald1 Kcnj14 Tpm1 Myl3 Neb Rlc-a Kcnj11 Mylk Tnnt3 Kcnj12 Abcc9 Gucy1a1 Tnnt2 Gucy1a2 Tnnt1 Myl7 Tnnc2 Myl11 Tnnc1 Myl9 Atp2b1 Myh3 Camk2g Dmd Sorbs3 Atp2b4 Actn3 Camk2d Atp2b3 Myh6 Camk2b Tcap Des Mybpc2 Mybpc3 Actn2 Sri Camk2a Atp1b1 Atp1b3 Atp1b2 Ryr2 Ryr1 Fkbp1b Dmpk Atp1a2 Fxyd3 Atp1a1 Fxyd4 Fxyd1 Atp1a4 Atp1a3 Fxyd2 Fxyd7 Fxyd6 Clic2 Trdn Ahcyl1 Pln Asph Trpc1 Stim1 Tnni3 Cacng8 Vcl Mme Ces1d Slc8a1 Slc8a2 Slc8a3 Tmod3 Nos1 Kcnk4 Kcnk2 Kcnk1 Kcnk10 Kcnk16 Kcnk9 Kcnk7 Kcnk18 Kcnk6 Cacng6 Cacng7 Kcnd3 Kcnd2 Kcnd1 Kcnip3 Kcnip4 Kcnip1 Kcnip2 Vim Kcnk12 Kcnk15 Npr1 Npr2 Kcnk5 Corin Nppc Nppa Kcnk13 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 96%10222901 Activation of GABAB receptors Adcy5 Adcy6 Adcy9 Gnai2 Gnai1 Gnai3 Gng3 Gnal Gng5 Gng4 Gabbr1 Gng7 Gng8 Kcnj9 Gngt1 Gabbr2 Gnat3 Kcnj6 Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Kcnj12 Gnb4 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 AMINO ACIDS REGULATE MTORC1%REACTOME DATABASE ID RELEASE 96%10225317 Amino acids regulate mTORC1 Atp6v0b Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v1c1 Atp6v0c Atp6v1e2 Sesn2 Atp6v1e1 Tcirg1 Sesn1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Nprl3 Nprl2 Wdr59 Mios Depdc5 Wdr24 Lamtor3 Fnip1 Lamtor2 Fnip2 Samtor Rptor RragB Itfg2 Castor2 Castor1 Mtor Sec13 Rheb Szt2 Slc38a9 Lamtor5 Lamtor4 Kics2 Rraga Flcn Lamtor1 Rragc Sh3bp4 Rragd Mlst8 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%10222741 Asparagine N-linked glycosylation Srd5a3 Fut8 Fuca1 Man2a1 Man2a2 Mgat2 Dpm2 Spta1 Sptb Sptbn1 Sptbn2 Sptan1 Gmppa Alg9 Pmm2 Sptbn5 Alg8 Mpi Alg6 Pmm1 Alg3 Sptbn4 Sar1b Alg2 Alg13 Alg14 Alg12 Mpdu1 Dpagt1 Tgfa Areg Nagk Gnpnat1 Amdhd2 Uap1 Gfpt1 Gfpt2 Pgm3 Renbp Amfr Engase Ngly1 B4galt4 B4galt5 B4galt6 B4galt2 B4galt3 Rps27a Rab1b Trappc2l Uba52 Trappc10 Psmc1 Mgat5 Ubb Mgat1 Slc35c1 Mgat3 Ubc Manea Man1c1 Man1a2 Man1a1 Mgat4c Mgat4b Trappc6b Trappc6a Trappc9 Trappc5 Trappc4 Trappc3 Trappc2 Trappc1 Ins1 Cd55 Lman1 Scfd1 Mvd Actr1a Lman2 Ins2 Sec22a Dctn1 Tfg Dctn2 Cog1 Cog2 Rab1A Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Cog6 Cog7 Cog8 Napa Nsf Napb Ank1 Napg Sec23a Tmem115 Kdelr2 Kdelr3 Sec23ip Sec16b Sec16a Dpm1 Lman2l Dpm3 Copa Bet1l Rad23b Cnih1 Gorasp1 Cnih3 Cnih2 Kdelr1 Arf4 Ctsc Arf3 Arf1 Ppp6r3 Mia2 Mia3 Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Col7a1 Ppp6c Sec31b Sec31a Gria1 Umod F8 Stx17 Asgr2 Asgr1 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Calr Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Pdia3 Ankrd28 Cd59 Arcn1 Bet1 B4galnt2 Ctsz Chst10 Ubxn1 Canx Dync1h1 St8sia6 St8sia4 St8sia5 Npl Neu2 Neu3 Neu4 Neu1 Dync1i2 Cmas Dync1i1 St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 Dhdds St3gal6 Nudt14 St6galnac2 Alg5 St3gal4 Dolpp1 St3gal5 Fuom St3gal2 Gmds St3gal3 Dolk Slc35a1 Fcsk St3gal1 Dhrsx Nanp Nus1 St6gal1 Fpgt Glb1 St6gal2 Gfus Nans St8sia2 Mgat4a St8sia3 St8sia1 Ctsa Gne Sec13 Dync1li2 Vcp Dync1li1 Dynll1 Dynll2 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-RNO-446388.1 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Arhgef6 Pxn Parvb Parva Actn1 Tesk1 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%R-RNO-1480926.1 O2 CO2 exchange in erythrocytes Cyb5r1 Slc4a1 Aqp1 Ca1 Ca2 Cyb5r4 Ca4 Cyb5r2 Hba1 Cyb5rl Hbb Rhag ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 96%10222899 Adenylate cyclase inhibitory pathway Adcy5 Adcy6 Gnat3 Adcy9 Gnai2 Gnai1 Gnai3 Adcy3 Adcy4 Gnal Adcy1 Adcy2 Adcy7 Adcy8 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME%R-RNO-4570464.1 SUMOylation of RNA binding proteins Phc1 Nup133 Sumo3 Cbx4 Nup210 Nup155 Nup153 Cbx2 Ube2i Phc3 Pcgf2 Bmi1 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Rnf2 Nup160 Rae1 Ndc1 Hnrnpc Nup85 Nup42 Hnrnpk Nup62 Ring1 Nup43 Nup88 Aaas Phc2 Nop58 Ranbp2 Sumo1 Nup214 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 96%10224677 Phase 1 - inactivation of fast Na+ channels Kcnd3 Kcnd2 Kcnd1 Kcnip3 Kcnip4 Kcnip1 Kcnip2 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 96%10222415 Developmental Biology Erbb2 Gsk3b Frs2 Prkcq Ranbp9 Tln1 Rasa1 Fgfr1 Creb1 Ret Spta1 Col4a1 Ptpra Col4a2 Stx1a Ncam1 Sptb Sptbn1 Sptbn2 Mark3 Ptk2 Sema5a Mapk3 Sptan1 Sptbn5 Artn Rps6ka5 Nras Gfra1 Sptbn4 Grb2 Gfra2 Fyn Gfra4 Kras Sos1 Hras Mapk7 Kit Tnfsf11 Kitlg Map2k2 Map2k1 Rps6ka1 Cacng8 Egfr Cacng3 Shc3 Mapk14 Pspn Dcc Gdnf Pkp1 Dpysl2 Dsc1 Kif4b Ap2s1 Kif4a Rdx Msn L1cam Dnm3 Ap2a2 Ap2a1 Ap2b1 Nrtn Numb Sh3gl2 Mapk11 Ezr Itgav Itga2b Met Mapk12 Itgb1 Grb10 Itgb3 Akt3 Akt2 Akt1 Sh3kbp1 Dok1 Itga9 Rab27a Pak1 Pak2 Lyn Yes1 Src Rlc-a Rhoa Ngef Dlg4 Grin1 Grin2b Ube2i Reln Dab1 Cdh2 Rhob Sirt1 Sumo1 Myog Myod1 Mef2d Boc Ctnna2 Bnip2 Spag9 Dok2 Mef2a Mef2b Mef2c Myf6 Tcf4 Myf5 Qars1 Lars1 Rars1 Kars1 Myo5a Sox10 Aimp2 Eprs1 Iars1 Tbx3 Cdh15 Mars1 Myrip Sytl2 Dars1 Pik3ca Shc1 Gab2 Farp2 Pip5k1c Csf1 Pik3r1 Pik3cb Pik3r2 Pik3r3 Hint1 Mitf Pik3cd Gab1 Pparg Irs2 Xpo1 Vldlr Klk13 Cdon Ctnnb1 Tcf7 Tcf7l1 Tcf7l2 Cacng4 Cacng2 Ptprc Stx1b Lgi2 Sdc2 Lgi3 Lgi4 Cdsn Lgi1 Klk5 Adam23 Adam11 Kazn Klk8 Adam22 Sprr3 Lef1 Tgm1 Stfa2l3 Casp14 Evpl Spink6 Cela2a Spink5 Perp Klk12 Pkp2 Arpc3 Pkp3 Arpc2 Dsg3 Lipk Sema4d Dsg4 Plxnb1 Dsc2 Arpc5 Ctnna1 Arpc4 Rptn Lipm Klk14 Dsc3 Dnm2 Jup Lipn Dsp Nrp1 Dsg1 Dsg2 Efna1 Efna2 Epha1 Epha3 Hsp90ab1 Epha4 Epha5 Epha6 Epha7 Epha10 Efna4 Efna5 Ppl Arpc1b Actr2 Arpc1a Actr3 Arhgef28 Krt1 Rhoc Cd72 Plxnb3 Sema6d Crmp1 Plxna4 Shank3 Myo9b Plxna3 Plxna2 Rras Tyrobp Plcg1 Sema4a Dpysl3 Dpysl4 Dpysl5 Arhgap35 Plxnc1 Sema3a Sema7a Fes Trem2 Sema3e Plxna1 Sdcbp Efnb1 Rock2 Arhgef7 Rock1 Efnb2 Efnb3 Ephb1 Plxnd1 Dscaml1 Ephb2 Ntn4 Ephb3 Ephb4 Dscam Ephb6 Unc5a Nck2 Rac1 Pak3 Rnd1 Git1 Hsp90aa1 Limk1 Rxra Nck1 Actb Hdac3 Rara Foxo3 Mmp2 Mmp9 Ncor2 Cdk2 Lypla2 Gap43 Mapk1 Grb7 Prkaca Prkacb Pdlim7 Dok4 Dok5 Prkca Dok6 Cdk5r1 Ank1 Smad2 Cdk5 Smad3 Smad4 Nfasc Krtap24-1 Krtap13-1 Krtap10-9 LOC120093742 Krtap11-1 Adgrg6 Krtap31-2 Krtap31-1 Krt33b Krt33a Epha2 Cebpa Krtap2-4l1 Krtap3-1 Krt4 Krt2 Krtap3-2 Krt8 Krt7 Krt5 Krt9 LOC680428 Krt27 Krt28 Krt25 Krt26 Krtap29-1 Krt24 Krt20 LOC134481131 LOC102553726 Krtap5-8 Krt39 Krt36 Krt34 Krt35 Krt32 Krt31 AABR07001416.1 Krtap6-5 Krt18 Krt19 Krt17 Krt14 Krt15 Krt12 Krt13 Krt10 Krtap16-5 Krtap16-1 Krt6a Krt71 Krt78 Krt76 Krt77 Krt75 Krt72 Krt73 Krt40 Krtap1-3 Abl1 Krtap1-1 Krtap1-5 LOC134478810 Krt82 Krt80 Krt85 Krt86 Rap1gap Krt83 Krt84 LOC102551497 Crebbp Tcf3 Sin3a Csnk2a2 Csnk2a1 Actg1 Hdac1 Csnk2b Tfap2c Tiam1 Tfap2a Tfap2b Ep300 Arhgef11 Arhgef12 Vav3 Tcf12 Vav2 Itsn1 Ptpn11 Psenen Psen1 Psen2 Kalrn Ncstn Aph1a Aph1b St8sia4 Trio St8sia2 Ap2m1 Clta Cltc Dnm1 Foxo1 Cdc42 Cdk4 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-RNO-8964616.1 G beta:gamma signalling through CDC42 Arhgef6 Gng7 Gng8 Gngt1 Pak1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng10-ps1 Gng3 Cdc42 Gng5 Gng4 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-RNO-174048.1 APC C:Cdc20 mediated degradation of Cyclin B Ccnb1 Uba52 Anapc10 Ube2d1 Anapc16 Ube2s Cdc16 Anapc15 Cdk1 Rps27a Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Ubb Anapc7 Cdc20 Ubc Ube2e1 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 96%10225077 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Cbfb Runx1 Foxp3 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190872.1 Transport of connexons to the plasma membrane Gjb2 Gja1 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 96%10225045 Carboxyterminal post-translational modifications of tubulin Ttll6 Ttll7 Ttll4 Ttll5 Ttll10 Ttll2 Ttll3 Ttll11 Ttll12 Ttll8 Ttll13 Ttll9 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME%R-RNO-1971475.1 Glycosaminoglycan-protein linkage region biosynthesis Gpc1 Gpc3 Gpc2 Gpc5 Cspg5 Gpc4 Bgn Cspg4 Gpc6 B3galt6 Fam20b B4galt7 Pxylp1 Sdc1 Xylt1 Xylt2 Bcan Vcan Agrn Ncan Dcn Sdc4 Sdc3 Sdc2 Uxs1 PI-3K CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 96%10223027 PI-3K cascade:FGFR2 Fgf16 Fgf17 Pik3ca Fgf18 Frs2 Fgf10 Pik3r1 Grb2 Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgf7 Fgf9 Gab1 Fgfr2 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 96%10222719 Gamma-carboxylation of protein precursors Pros1 F10 F7 F9 Ggcx Bglap F2 Proc Proz FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-RNO-9614085.1 FOXO-mediated transcription Ywhag Foxo4 Crebbp Smad2 Smad3 Foxo6 Smad4 Akt3 Akt2 Akt1 Ep300 Foxo1 Foxg1 Sirt3 Sirt1 Atxn3 Ywhaq Kat2b Sfn Ywhab Foxo3 Ywhaz REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-RNO-9614399.1 Regulation of localization of FOXO transcription factors Ywhag Foxo1 Foxo4 Ywhaq Foxo6 Akt3 Akt2 Sfn Ywhab Akt1 Foxo3 Ywhaz BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-RNO-9018677.1 Biosynthesis of DHA-derived SPMs Alox12 Cyp3a9 Gpx4 Hpgd Alox5 Lta4h Alox15 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Ephx2 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a62 Cyp3a2 Ptgs2 Gstm4 Ltc4s PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 96%10224351 Pre-NOTCH Expression and Processing Tmed2 Prkci Notch4 Elf3 Notch3 GALACTOSE CATABOLISM%REACTOME%R-RNO-70370.1 Galactose catabolism Galt Galm Galk1 Pgm1 Gale FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 96%10222671 FXIIa, PKa activate coagulation factors Kng1 F12 F11 F9 Gp5 Gp9 Gp1bb Gp1ba Klkb1 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10222273 Organic anion transport by SLC5 17 25 transporters Slc25a10 Slc5a8 Slc25a1 Slc5a12 Slc25a11 Slc17a5 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-RNO-434313.1 Intracellular metabolism of fatty acids regulates insulin secretion Cd36 Acsl3 Acsl4 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 96%10224605 SUMOylation of DNA replication proteins Nup133 Sumo3 Nup210 Nup155 Pias4 Nup153 Ube2i Cdca8 Incenp Aurkb Top2b Top2a Top1 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Rangap1 Nup37 Pom121 Sumo2 Nup205 Nup107 Pcna Nup188 Tpr Nup160 Rae1 Ndc1 Pias3 Nup85 Nup42 Nup62 Nup43 Nup88 Birc5 Aaas Ranbp2 Sumo1 Nup214 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-RNO-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Bcl11b Smarcc1 Phf10 Smarca2 Smarca4 Arid1a Arid1b Actl6a Smarcd1 Ss18 Smarce1 Smarcd3 Smarcd2 Dpf2 Actg1 Bcl7a Smarcb1 Bcl7b Bcl7c Bcl11a INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223887 Interleukin-33 signaling Il1rap Il1rl1 Il33 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%10222985 Cobalamin (Cbl, vitamin B12) transport and metabolism Ldlrap1 Mtr Mmachc Mmadhc Lrpl1 Abcc1 Amn Cblif Tcn2 Mmut Mmaa Cubn Mtrr Mmab Lrp2 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 96%10224185 TWIK related potassium channel (TREK) Kcnk4 Kcnk2 Kcnk10 LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-RNO-5632681.1 Ligand-receptor interactions Cdon Dhh Ptch1 Hhip Ihh Shh INTERLEUKIN-23 SIGNALING%REACTOME%R-RNO-9020933.1 Interleukin-23 signaling Il23a P4hb Jak2 Il23r Tyk2 Stat3 Il12rb1 Il12b DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224213 Downregulation of ERBB2 signaling Erbb2 Erbb3 Ereg Uba52 Ptpn12 Nrg2 Nrg3 Btc Egf Cul5 Ubb Ubc Ptpn18 Usp8 Ptk7 Egfr Rnf41 Akt3 Hbegf Akt2 Akt1 Hsp90aa1 Stub1 Rps27a Cdc37 SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 96%10222919 Signaling by Activin Tgfbr3 Inha Smad2 Smad3 Smad4 Mapk3 Inhba Inhbb Fstl3 Mapk1 Fst Acvr1c Acvr1b Acvr2b Acvr2a FRS-MEDIATED FGFR2 SIGNALING%REACTOME%R-RNO-5654700.1 FRS-mediated FGFR2 signaling Frs2 Frs3 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Fgfr2 Fgf16 Fgf17 Fgf18 Fgf10 Nras Grb2 Kras Sos1 Hras Ptpn11 Fgf20 Fgf23 Fgf22 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 96%10223455 Insulin processing Exoc3 Exoc4 Exoc5 Ero1b Exoc6 Ins2 Exoc1 Exoc2 Exoc7 Exoc8 Slc30a5 Slc30a8 P4hb Ins1 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 96%10223515 Ligand-independent caspase activation via DCC Casp3 Casp9 Dcc Appl1 PHASE 2 - PLATEAU PHASE%REACTOME%R-RNO-5576893.1 Phase 2 - plateau phase Kcne3 Kcne2 Cacng8 Cacnb1 Cacnb2 Cacng4 Cacna2d2 Cacna1c Cacng6 Cacng7 Akap9 Kcne5 Kcnq1 Kcne4 SIGNAL TRANSDUCTION BY L1%REACTOME%R-RNO-445144.1 Signal transduction by L1 Csnk2b Egfr Ncam1 Pak1 Rac1 Itga2b Mapk3 Map2k2 Map2k1 Mapk1 Csnk2a2 L1cam Vav2 Nrp1 Csnk2a1 Itgb1 Itgb3 Itgav Itga9 Fgfr1 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223843 Zinc transporters Slc30a1 Slc39a4 Slc39a3 Slc39a2 Slc39a1 Slc30a5 Slc39a8 Slc30a8 Slc39a7 Slc39a6 Slc39a14 COX REACTIONS%REACTOME DATABASE ID RELEASE 96%10222607 COX reactions Ptgs1 POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 96%10224097 Potassium Channels Kcna10 Kcna2 Kcnb1 Kcns3 Kcnc4 Kcna1 Kcnc2 Kcnc3 Kcng2 Kcnc1 Kcng4 Kcng3 Kcng1 Kcnh1 Kcnv2 Kcnv1 Kcnmb1 Kcnmb2 Kcnmb3 Kcnmb4 Kcnn4 Kcnn3 Gng3 Kcnn2 Hcn3 Kcna5 Hcn4 Kcnma1 Gng5 Gng4 Hcn1 Kcnq1 Hcn2 Gabbr1 Gng7 Kcnh2 Gng8 Kcnj9 Gngt1 Gabbr2 Kcnj8 Kcnj6 Kcnk4 Kcnj5 Kcnk2 Kcnj4 Kcnk1 Kcnj3 Kcnk10 Kcnk16 Kcnj10 Kcnj2 Kcnk9 Kcnj1 Kcnk7 Kcnk18 Kcnj14 Gnb2 Abcc8 Kcnk6 Gnb1 Kcnj11 Kcnj12 Gnb4 Abcc9 Gnb3 Kcnj15 Gnb5 Kcnj16 Gng11 Kcnd3 Kcnd2 Kcnd1 Kcnab2 Kcnb2 Kcnh8 Kcnh7 Kcnh6 Kcnh5 Kcnh4 Kcnf1 Kcnh3 Kcnq5 Gng10-ps1 Kcnk13 Kcnab1 Kcns2 Kcns1 Kcnab3 Kcna7 Kcna6 Kcna4 Kcna3 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 96%10222347 Beta oxidation of hexanoyl-CoA to butanoyl-CoA Hadha Hadhb Echs1 Hadh Acads INTERLEUKIN-10 SIGNALING%REACTOME%R-RNO-6783783.1 Interleukin-10 signaling Il10 Tyk2 Stat3 Il10rb Il10ra ABACAVIR METABOLISM%REACTOME%R-RNO-2161541.1 Abacavir metabolism Adh1 Nt5c2 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-RNO-2187335.1 The retinoid cycle in cones (daylight vision) Opn1mw Rlbp1 Awat2 Opn1sw Dhrs3 Rbp3 EICOSANOIDS%REACTOME DATABASE ID RELEASE 96%10222331 Eicosanoids Cyp8b1 Cyp4f39 Cyp4f1 Cyp4a14 Tbxas1 Cyp4f3 Cyp4a12 Ptgis Cyp4f40 Cyp4b1 Cyp4f4 Cyp4a10 Cyp4a2 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-RNO-450520.1 HuR (ELAVL1) binds and stabilizes mRNA Tnfsf13 Xpo1 Set Anp32a Prkcd Elavl1 Nup214 Prkca INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 96%10222609 Initiation of coagulation cascade F10 F3 F7 F9 F2 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225165 RAC1 GTPase cycle Vamp3 Garre1 AABR07032856.1 Nisch Nckap1l Snap23 Jag1 Pak1 Nox3 Nox1 Pak2 Amigo2 Noxa1 Emd Baiap2l1 Ngef Fgd5 Taok3 Sos1 Chn2 Esyt1 Abi2 Abi1 Iqgap2 Pak6 Pak4 Vrk2 Git2 Arhgap12 Abl2 Epha2 Slc1a5 Srgap1 Ncf1 Arhgap45 Ncf2 Ykt6 Ncf4 Brk1 Bcr Arhgap5 Arhgap15 Arhgap4 Arhgap17 Arhgap1 Arap1 Arap3 Arap2 Arhgap25 Arhgap9 Arhgap27 Mcam Pld1 Arhgap33 Wasf3 Wasf2 Wasf1 Plekhg1 Ralbp1 Cdc42bpa Pard6a Arhgdib Gmip Arhgap10 Iqgap3 Fermt2 Diaph3 Rasgrf2 Depdc1b Cit Fam13a Arhgap22 Nckap1 Arhgap21 Arhgap20 Arhgap26 Cyfip2 Arhgap24 Cyfip1 Arhgap23 Arhgap29 Ophn1 Dock2 Def6 Fam13b Myo9b Pak5 Arhgap31 Arhgap30 Prex2 Noxo1 Arhgap35 Mpp7 Cyba Srgap2 Cybb Tagap Srgap3 Racgap1 Plekhg6 Cdc42ep1 Plekhg3 Cdc42ep4 Itgb1 Ktn1 Farp1 Syde2 Dlc1 Pld2 Pkn2 Arhgef7 Pkn1 Arhgap44 Arhgap42 Pik3ca Spata13 Tiam1 Arhgap32 Mcf2l Tiam2 Cav1 Rac1 Pak3 Swap70 Git1 Farp2 Arhgef15 Baiap2 Arhgef11 Pik3r1 Arhgef10 Arhgef19 Vav3 Dock5 Pik3r2 Dock6 Pik3r3 Vav1 Vav2 Dock3 Dock4 Dock7 Tfrc Arhgef25 Dock8 Fmnl1 Sh3bp1 Sos2 Kalrn Arhgef6 Arhgef5 Arhgef4 Gna13 Abr Dock10 Dock11 Arhgef39 Ect2 Prex1 Trio Plekhg2 Rab7a Lamtor1 Lbr Cdc42 Mcf2 Arhgdia Als2 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 96%10222017 Glucuronidation Ugt1a2 Ugt1a1 Ugt1a3 Ugt1a5 Ugt2b1 Ugt1a6 Ugt1a7 Slc35d1 Ugt2b7 Ugt1a8 AC114845.1 Ugt2b34l1 Ugt2b Ugt2a1 Ugt2a3 Uxs1 Ugt2b17 Ugt2b37 Ugp2 Ugt2b15 Ugdh Ugt3a1 Abhd10 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%10222197 Programmed Cell Death Ywhag Apip Casp7 Apaf1 Diablol1 Ctnnb1 Prkcq Prkcd Septin4 Bak1 Nmt1 Gzmb Bid Xiap Gsn Casp6 Gas2 Sh3glb2 Add1 Il1a Il1b Mlkl Flot2 Flot1 Ptk2 Mapk3 Ripk3 Tradd Sptan1 Cflar Prkn Stub1 Ripk1 Tnfsf10 Pdcd6ip Fas Cdc37 Fadd Faslg Bcl2l1 Acin1 Ube2l3 Bmf Mapk8 Opa1 Oma1 Peli1 Gsdme Gsdmd Apc Traf2 Tjp1 Dsg3 Cdh1 Il18 Dsp Dsg1 Dsg2 Kpnb1 Hmgb1-ps34 Ppp3r1 Kpna1 Clspn Casp8 Chmp2b Cycsl2 Dcc Appl1 Chmp3 Pkp1 Hmgb1l2 Chmp7 Hmgb1l1 H1-1 Chmp6 Lmna H1-0 H1-5 H1-4 H4f3 Hmgb2 Fnta Chmp4c Dffa Chmp4bl1 Dffb Cycs Ywhab Ocln Birc2 Bax Plec Bcap31 Satb1 Sdcbp Rock1 Tjp2 Elane Bcl2l11 Stk26 Stk24 Dnm1l Hsp90aa1 Itch Rps27a Lmnb1 Sfn Vim Chmp2a Uba52 Mapt Ppp3cc Pmaip1 Bad Casp3 Casp9 Ubb Ogt Ubc Casp1 Ywhae Mapk1 Bmx Dynll1 Dynll2 Ywhaq Ywhah Ly96 Ticam2 Ticam1 Cd14 Tlr4 Ywhaz P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-RNO-69613.1 p53-Independent G1 S DNA Damage Checkpoint Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Fbxw11 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Chek1 Psmc3 Chek2 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Mapk14 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cdc25a Mapk11 Skp1 Psmb5 Plk3 Psmb4 Csnk1e Psmb7 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 96%10225471 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Sin3a Lef1 Hint1 Tcf7l1 Tcf7l2 Ctnnb1 Hdac1 Tcf7 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%10222059 Transmission across Chemical Synapses Gls2 Cacnb3 Cacnb4 Creb1 Cacnb1 Cacna1e Cacnb2 Stx1a Cacna1a Cacna1b Cacna2d3 Cacng4 Cacna2d2 Cacng2 Vamp2 Lin7b Rps6ka3 Rps6ka1 Rps6ka2 Cacng8 Cacng3 Chrnb4 Chrnb3 Chrnb2 Grip2 Prkcb Epb41l1 Gabrg2 Gabrg3 Grin3a Chrna3 Chrna2 Ap2s1 Chrna1 Chrna7 Grik5 Chrna6 Chrna5 Chrna4 Grik4 Ap2a2 Ap2a1 Chrna9 Grik3 Ap2b1 Pick1 Gabra4 Gabra3 Gabra6 Gabra5 Gabra2 Gabra1 Akap5 Glra3 Glra2 Glra1 Rps6ka6 Tspan7 Camk1 Glrb Ncald Grip1 Chrnd Gabrr1 Chrne Gabrr3 Gabrr2 Chrng Gabrq Gabrb1 Gabrb3 Slc18a3 Gabrb2 Htr3b Htr3a Gabbr1 Gabbr2 Dnajc5 Hspa8 Rab3a Slc5a7 Gng10-ps1 Adcy3 Adcy4 Adcy1 Adcy2 Camkk1 Adcy7 Camkk2 Adcy8 Adcy5 Adcy6 Tomt Adcy9 Prkaca Prkacb Prkcg Gnai2 Gnai1 Prkca Slc1a1 Gnai3 Camk4 Prkar1a Slc38a2 Prkar1b Slc1a7 Calm3 Slc1a6 Nsf Gng3 Gnal Gng5 Slc6a12 Gng4 Gng7 Gng8 Gngt1 Kcnj9 Gnat3 Prkar2a Kcnj6 Prkar2b Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Gnb2 Gnb1 Gnb4 Kcnj12 Grin2a Gnb3 Lrrc7 Gnb5 Kcnj15 Gng11 Gria4 Kcnj16 Slc22a2 Gria3 Camk2g Camk2d Slc22a1 Gria2 Slc32a1 Camk2b Dlg1 Dlg2 Gria1 Actn2 Slc6a11 Dlg3 Slc6a13 Dlg4 Camk2a Nefl Grin1 Aldh5a1 Grik2 Grin2d Grik1 Grin2c Slc17a7 Naaa Abat Grin2b Slc6a1 Syn3 Slc6a4 Syn2 Slc6a3 Syn1 Cask Chat Lin7a Lin7c Gad1 Gad2 Apba1 Arl6ip5 Rims1 Maoa Tspoap1 Syt1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Unc13b Snap25 Slc18a2 Cplx1 Aldh2 Arhgef9 Gls Slc38a1 Ap2m1 Slc1a3 Slc1a2 Glul Myo6 Comt GLYCOLYSIS%REACTOME DATABASE ID RELEASE 96%10222013 Glycolysis Aldoa Nup133 Pfkl Nup210 Nup155 Pgk2 Nup153 Pfkm Pfkp Pgm2l1 Pkml1 Gck Hk2 Hk3 Adpgk Tpi1l2 Aldob Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Gnpda1 Gpi Nup205 Gnpda2 Nup107 Eno3 Sec13 Eno2 Eno4 Nup188 Pfkfb4 Tpr Pfkfb3 Pfkfb2 Nup160 Pgk1 Pfkfb1 Rae1 Pgam2 Ndc1 Pgam1 Tpi1 Nup85 Nup42 Nup62 Hkdc1 Nup43 Nup88 Gckr Aaas Pklr Ranbp2 Gapdhs Aldoc Nup214 Bpgm LINOLEIC ACID (LA) METABOLISM%REACTOME DATABASE ID RELEASE 96%10224381 Linoleic acid (LA) metabolism Fads1 Elovl2 Elovl3 Abcd1 Elovl5 Elovl1 Acsl1 Fads2 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 96%10224505 SUMOylation of DNA damage response and repair proteins Nsmce1 Phc1 Nup133 Sumo3 Nsmce2 Cbx4 Nup210 Nup155 Xpc Nup153 Cbx2 Stag2 Phc3 Stag1 Rad52 Mageb10 Sp100 Pcgf2 Bmi1 Brca1 Smc1a Sumo2 Rnf2 Tdg Blm Pml Pias4 Ube2i Rpa1 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Parp1 Nup37 Pom121 Nup205 Nup107 Sec13 Xrcc4 Nup188 Tpr Nup160 Rae1 Smc6 Smc5 Ndc1 Smc3 Nup85 Sp140 Nup42 Pias1 Nup62 Pias2 Nup43 Ring1 Nsmce4a Nup88 Aaas Eid3 Herc2 Ranbp2 Rnf168 Phc2 Sumo1 Cetn2 Nup214 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 96%10222055 Astrocytic Glutamate-Glutamine Uptake And Metabolism Glul Slc38a1 Slc1a3 Slc1a2 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%10223467 ABC transporters in lipid homeostasis Abca9 Abca7 Abcd1 Abcd2 Abcd3 Apoa1 Abcg4 Abcg8 Abcg5 Abca3 Pex19 Abca12 Abca2 Abca5 Pex3 Abca6 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 96%10224499 SUMO is transferred from E1 to E2 (UBE2I, UBC9) Ube2i Uba2 Rwdd2b Sae1 Sumo1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-RNO-418885.1 DCC mediated attractive signaling Fyn Trio Rac1 Cdc42 Dcc Ptk2 Nck1 Src GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME DATABASE ID RELEASE 96%10222107 Glycogen breakdown (glycogenolysis) Phkg1 Gaa Phkg2 Agl Pygl Pygm Phkb Akr1e2 Phka1 Phka2 Gyg1 Pgm1 Calm3 REGULATION OF NF-KAPPA B SIGNALING%REACTOME DATABASE ID RELEASE 96%10225371 Regulation of NF-kappa B signaling N4bp1 Ikbkg Casp8 Uba52 Lrrc14 Traf2 Nlrx1 Rps27a Usp14 Usp18 Nlrc5 Chuk Ikbkb Ubb Ubc Traf6 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 96%10221923 G1 S Transition Ppp2cb Ccnd1 Ppp2ca Cdk7 Mnat1 Ppp2r1b Psma4 Ppp2r1a Ccna1 Psma3 Akt3 Ccna2 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Ppp2r3b Psmd11 Psmd14 Psmd13 Cdc25a Orc4 Orc6 Orc1 Skp2 Orc3 Skp1 Orc2 Cdt1 Psmb5 Gmnn Psmb4 Ptk6 Psmb7 Cdc7 Psmb6 Cdc6 Mcm7 Psmb1 Mcm8 Psmb3 Dbf4 Psmb2 Uba52 Cks1b Cables1 Psma7 Mcm3 Mcm4 Mcm5 Psmc5 Mcm10 Psmc2 Mcm2 Psmc1 Pole3 Psmc4 Pole2 Psmc3 Pole4 Rpa1 Rpa2 Wee1 Ubb Rpa3 Ubc Psmb6l1 Cdkn1b Psmd7 Pole Rb1 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Pola2 Cul1 Ccnh Cdk2 Pola1 Prim2 Prim1 Cdk4 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-RNO-2404192.1 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Cilp Pdpk1 Frs2 Trib3 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Them4 Pde3b Tlr9 Fgf17 Pik3ca Fgf18 Shc1 Fgf19 Gab2 Fgf10 Akt2 Pik3r1 Pik3cb Pik3r2 Grb2 Sos1 Ptpn11 Fgf20 Fgf23 Fgf22 Pik3c3 Gab1 Irs2 Pik3r4 Klb Irs1 Fgf2 Fgf1 Fgf4 Igf1r Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Igf2 Igf1 Kl Flt3 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 96%10225203 Biosynthesis of aspirin-triggered D-series resolvins Gpx4 Alox5 Lta4h M PHASE%REACTOME%R-RNO-68886.1 M Phase Ywhag Spdl1 Nup133 Nup210 Nup155 Bub1 Nup153 Itgb3bp Zwilch Nek9 Ctdnep1 Cnep1r1 Lpin3 Lpin2 Ofd1 Mapk3 Emd Tuba1b Ppp2r5b Ppp2r5a Vrk2 Ppp1cc Ppp2r5e Mastl Arpp19 Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Kpnb1 Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Tuba1c Tubal3 Nme7 Rcc1 Cep152 Tuba4a Chmp2b Tubgcp2 Cc2d1b Spast Prkcb Haus4 Tubb2b Haus5 Tubb2a Haus6 Ist1 Pcnt Sfi1 Hdac8 Chmp3 Vrk1 Haus1 Chmp7 Tubgcp6 Chmp6 Tubgcp5 Lmna Tubgcp4 Vps4a Tubgcp3 Sirt2 Cep250 Tuba8 Cep290 Cep78 Chmp4c Cep76 Tuba3b Cep72 Chmp4bl1 Tubb6 Cep164 Cep70 Tubb3 Cpap Tubb1 Tubb5 Banf1 Plk4 Ran Ankle2 Odf2 Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Kif23 Rab1b Cdc20 Psmb5 Psmb4 Psmb7 Chmp2a Kif20a Psmb6 Ppp2r2a Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Psmd7 Ywhae Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 Cdk1 Mapk1 Lbr Actr1a Ppp2cb Ppp2ca Dctn1 Dctn2 Prkaca Rab1A Prkca Ppp2r5d Akap9 Prkar2b Gorasp1 Ppp2r1b Ppp2r1a Nipbl Ncapd2 Mau2 Ncapg Smc4 Ncaph Smc2 Eml4 Wapl Numa1 Pds5b Pds5a Cdca5 Csnk1d Ccp110 Ube2i Golga2 Firrm Set H2ab2 Rab2a Blzf1 Espl1 Ncaph2 Ncapd3 Kmt5a H2ac4 Ncapg2 Gorasp2 Mcph1 Smc3 ENSRNOG00000066901 Sumo1 Stag2 Stag1 H2ac18 Phf8 Csnk2a2 Csnk2a1 Hist1h2bq Smc1a Csnk2b H2aj Hist3h2ba ENSRNOG00000068602 Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint H2az2 Rps27 H2bc4 Hist1h4m Rcc2 H2bc1 Kif18a Nudc Dync1h1 Hist1h2ai Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Nup93 Cenpo Cenpn Nup50 Cenpm Mis12 Cenpl Cenpk Nup35 Cenpi Nup54 Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Nup58 Rangap1 Nup37 Clip1 Pom121 Sgo2 Nup205 Sgo1 Nup107 Sec13 Kif2a Kif2b Kif2c Nup188 Dync1li2 Tpr Pmf1 Nup160 Dync1li1 Rae1 Ahctf1 Mapre1 Ndc1 Dynll1 Dynll2 Kntc1 Nup85 Nup42 Nup62 Ndc80 Nup43 Nup88 Birc5 Aaas Ercc6l Ccnb2 Ranbp2 Ckap5 Nup214 Csnk1e BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223373 Basigin interactions Slc3a2 Ppia Atp1b1 Atp1b3 Atp1b2 Ppil2 Itgb1 Itga3 Cav1 Mmp1b Spn Slc16a3 Slc7a11 Slc16a8 Slc7a10 Slc16a1 L1cam Bsg Slc7a6 Itga6 Slc7a7 Slc7a5 Slc7a8 Mag Slc7a9 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10223531 Other semaphorin interactions Plxnd1 Cd72 Plxnb3 Sema6d Tyrobp Sema5a Sema4a Ptprc Sema4d Plxnc1 Sema7a Trem2 Sema3e Plxna1 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%10224777 SHC-mediated cascade:FGFR4 Fgf16 Fgf17 Shc1 Fgf18 Fgf19 Nras Grb2 Kras Klb Sos1 Hras Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf6 Fgf8 Fgfr4 Fgf9 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%10222763 Mitochondrial transcription termination Mterf1 PHYSIOLOGICAL FACTORS%REACTOME%R-RNO-5578768.1 Physiological factors Corin Nppc Nppa Mme Npr1 Ces1d Npr2 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%10225419 Transcriptional and post-translational regulation of MITF-M expression and activity Tnfsf11 Xpo1 Gsk3b Ube2i Crebbp Kitlg Qars1 Lars1 Rars1 Kars1 Rps6ka1 Sox10 Aimp2 Eprs1 Iars1 Tbx3 Mars1 Dars1 Mark3 Akt3 Mapk3 Csf1 Ep300 Mapk1 Hint1 Mitf Sirt1 Kit Sumo1 PDE3B SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222727 PDE3B signalling Pde3b SPHINGOLIPID METABOLISM%REACTOME%R-RNO-428157.1 Sphingolipid metabolism Abcg2 Abcc1 A4galt Cerk M6pr B3galnt1 Ugcg B4galnt1 Ugt8 Gal3st1 B3gnt5 Mfsd2b Sptssa Cers6 Cers5 Cers4 Cers3 Cers2 Sgms1 Sgms2 Sptlc1 Sptlc2 Aldh3a2 Sptlc3 Fa2h Sphk2 Spns2 Kdsr Degs2 Degs1 Ormdl2 Sphk1 St8sia5 Arsa Smpd2 Neu2 Smpd3 Neu3 Smpd4 Neu4 Smpd1 Neu1 Gba1 Gba3 St6galnac5 Gba2 St6galnac6 Enpp7 Galc Asah2 Asah1 Sts Gm2a Acer1 Acer2 St3gal5 Arsl Aldh3b1 St3gal2 Arsk Sgpl1 St3gal3 Arsj Aldh3b2 Arsi Acer3 Arsg Sgpp2 Gla Plpp2 Sumf1 Plpp3 Glb1 Arsb Plpp1 Sumf2 Sgpp1 Ormdl3 Ctsa Fut2 Fut1 Cyb5b B3galt4 Glb1l Psap B4galt5 B4galt6 Glb1l3 Glb1l2 Hexa Hexb FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 96%10222565 Fibrin formation Fgb Fga Fgg Itga2b F13b Proc F13a1 Serpinc1 Serpine2 Serpina5 Itgb3 F2 Serpind1 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-RNO-8866427.1 VLDLR internalisation and degradation Cltc Mylip Uba52 Ap2s1 Rps27a Vldlr Ap2a2 Ap2a1 Ap2b1 Nr1h3 Pcsk9 Nr1h2 Ubb Ap2m1 Ubc Clta G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 96%10223347 G-protein beta:gamma signalling Arhgef6 Gng7 Pik3r5 Pik3cg Gng8 Gngt1 Pak1 Pdpk1 Akt3 Akt2 Gnb2 Akt1 Gnb1 Rhoa Gnb4 Gnb3 Gnb5 Gng11 Gng10-ps1 Pik3r6 Gng3 Cdc42 Gng5 Gng4 MITOTIC ANAPHASE%REACTOME%R-RNO-68882.1 Mitotic Anaphase Spdl1 Nup133 Nup155 Bub1 Itgb3bp Zwilch Emd Tuba1b Ppp2r5b Ppp2r5a Vrk2 Ppp1cc Ppp2r5e Tuba1a Kpnb1 Tuba1c Tubal3 Rcc1 Tuba4a Chmp2b Cc2d1b Spast Tubb2b Tubb2a Ist1 Hdac8 Chmp3 Vrk1 Chmp7 Chmp6 Lmna Vps4a Sirt2 Tuba8 Chmp4c Tuba3b Chmp4bl1 Tubb6 Tubb3 Tubb1 Banf1 Ran Ankle2 Tubb4b Tubb4a Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Cdc20 Psmb5 Psmb4 Psmb7 Chmp2a Psmb6 Ppp2r2a Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Psma7 Anapc15 Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cdc16 Cdk1 Lbr Ppp2cb Ppp2ca Ppp2r5d Ppp2r1b Ppp2r1a Wapl Pds5b Pds5a Cdca5 Ube2i Espl1 Smc3 Sumo1 Stag2 Stag1 Smc1a Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Rps27 Rcc2 Kif18a Nudc Dync1h1 Spc24 Spc25 Xpo1 Nuf2 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Nup93 Cenpo Cenpn Cenpm Mis12 Cenpl Cenpk Nup35 Cenpi Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Rangap1 Nup37 Clip1 Pom121 Sgo2 Nup205 Sgo1 Nup107 Sec13 Kif2a Kif2b Kif2c Nup188 Dync1li2 Pmf1 Nup160 Dync1li1 Ahctf1 Mapre1 Ndc1 Dynll1 Dynll2 Kntc1 Nup85 Ndc80 Nup43 Birc5 Ercc6l Ccnb2 Ranbp2 Ckap5 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME DATABASE ID RELEASE 96%10222771 AMPK inhibits chREBP transcriptional activation activity Adipoq Adipor2 Adipor1 Prkag2 Prkaa2 Prkab2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-RNO-2299718.1 Condensation of Prophase Chromosomes Ccnb1 Hist1h2ai Phf8 H2ac18 Hist1h2bq Rb1 H2aj Set Plk1 H2ab2 Ncaph2 Hist3h2ba Ncapd3 Kmt5a H2ac4 Smc4 Ncapg2 Cdk1 ENSRNOG00000068602 Smc2 Mcph1 ENSRNOG00000066901 H2az2 H2bc4 Hist1h4m H2bc1 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-RNO-380270.1 Recruitment of mitotic centrosome proteins and complexes Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Cdk11b Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Dync1h1 Csnk1d Ccp110 Dync1i2 Nde1 Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Tubg2 Clasp1 Tubg1 Ywhae Cep63 Nme7 Cep152 Tuba4a Plk1 Tubgcp2 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Tubgcp6 Cdk1 Tubgcp5 Tubgcp4 Tubgcp3 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 Mzt1 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-RNO-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane Ddost Cd274 Pdcd1 Stt3b Magt1 Mib2 Pdcd1lg2 Rpn2 Rpn1 Ostc Ost4 Tmem258b Tusc3 B3gnt3 Dad1 SIGNALING BY ROBO RECEPTORS%REACTOME%R-RNO-376176.1 Signaling by ROBO receptors Myo9b Rhoa ACETYLATION%REACTOME DATABASE ID RELEASE 96%10222689 Acetylation Nat1 Nat2 Nat3 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%10222943 Terminal pathway of complement C6 C5 CHOLINE CATABOLISM%REACTOME%R-RNO-6798163.1 Choline catabolism Aldh7a1 Slc44a1 Slc22a4 Slc44a2 Chdh Bhmt Sardh Dmgdh GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-RNO-6782210.1 Gap-filling DNA repair synthesis and ligation in TC-NER Xab2 Cdk7 Ppie Tcea1 Mnat1 Polk Prpf19 Usp7 Isy1 Rps27a Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Ercc6 Polr2i Polr2j Gtf2h2 Uba52 Gtf2h1 Gtf2h3 Gtf2h5 Ercc2 Ercc3 Lig3 Pole3 Pole2 Pole4 Znf830 Rpa1 Rpa2 Aqr Uvssa Ubb Rpa3 Ubc Lig1 Pole Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Xrcc1 Rfc2 Ccnh Pold4 Pold3 Ddb1 Cul4a Cul4b TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME%R-RNO-9860927.1 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Ikbkg Ppp2r2a Ppp2ca Stat1 Nfkb1 Rela Gna11 Anxa2 Itgb1 Itgb3 Gnaq Pde4d Capn2 Vcl Ptpn1 Ppp2r1b Ppp2r1a Ptk2 Capns1 Yap1 Ikbke Nfkbia Chuk Abl1 Ikbkb Itgav MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225057 MET activates PTK2 signaling Hgf Megf11 Lama4 Itga2 Itgb1 Itga3 Met Ptk2 Src PCP CE PATHWAY%REACTOME%R-RNO-4086400.1 PCP CE pathway Rac3 Prkcg Wnt5a Prkca Dvl1 Wnt11 Dvl2 Dvl3 Fzd3 Wnt1 Rac1 Fzd1 Fzd2 Psma4 Fzd5 Fzd4 Psma3 Fzd6 Fzd8 Psma6 Psma5 Rhoa Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Smurf2 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Arrb2 Psma7 Psmc5 Daam1 Psmc2 Psmc1 Psmc4 Psmc3 Fzd7 Wnt5b Ubb Ror1 Ap2m1 Ror2 Ubc Clta Cltb Wnt4 Psmb6l1 Cltc Psmd7 Prickle1 Psmd6 Psmd8 Psmd2 Prkcb Psmd1 Adrm1 Rac2 Pard6a Smurf1 Ap2s1 Pfn1 Ap2a2 Ap2a1 Ap2b1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-RNO-110313.1 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template Ufd1 Uba52 Usp10 Pole3 Pole2 Ube2l6 Pole4 Rchy1 Rpa1 Rpa2 Polk Trim25 Ubb Rpa3 Ubc Polh Mad2l2 Rev1 Rev3l Poli Pole Rfc5 Pold2 Pold1 Isg15 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pold4 Vcp Pclaf Pold3 Usp43 Rps27a Nploc4 Sprtn Uba7 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-RNO-179409.1 APC-Cdc20 mediated degradation of Nek2A Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Ube2s Cdc16 Anapc15 Rps27a Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Ubb Anapc7 Cdc20 Ubc Nek2l1 Ube2e1 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223965 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Chrna7 Chrna6 Chrna5 Chrnb4 Chrna4 Chrnb3 Chrnb2 Chrna9 Chrna3 Chrna2 Chrna1 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-RNO-8949215.1 Mitochondrial calcium ion transport Phb1 Pheta2 Micu2 Micu3 Slc8b1 Pmpcb Micu1 Pmpca Maip1 Afg3l2 Mcub Yme1l1 Mcu Parl Stoml2 Spg7 Phb2 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 96%10224921 Transcriptional activation of cell cycle inhibitor p21 Zfp385a Tp53 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223961 Presynaptic nicotinic acetylcholine receptors Chrna6 Chrna5 Chrnb4 Chrna4 Chrnb3 Chrnb2 Chrnd Chrne Chrna3 Chrna2 Chrng Chrna1 SDK INTERACTIONS%REACTOME%R-RNO-373756.1 SDK interactions Sdk1 Sdk2 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-RNO-203641.1 NOSTRIN mediated eNOS trafficking Nos3 Dnm2 Cav1 Nostrin NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-RNO-5654732.1 Negative regulation of FGFR3 signaling Ppp2cb Ppp2ca Uba52 Frs2 Fgf2 Fgf1 Fgf4 Fgf5 Ubb Fgf8 Fgfr3 Ubc Fgf9 Fgf16 Fgf17 Fgf18 Braf Ppp2r1a Mapk3 Src Spry2 Mknk1 Cbl Mapk1 Rps27a Grb2 Ptpn11 Fgf20 Fgf23 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-RNO-9937383.1 Mitochondrial ribosome-associated quality control Mief1 Mrps9 Mrps2 Mrps7 Mrps5 Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl48 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Malsu1 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Ndufab1 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 AC132020.1 Mrpl15 Mrpl16 Mrpl17 Kgd4 Mrpl18 Mrpl19 Gadd45gip1 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 96%10224231 Acyl chain remodelling of PC Plb1 Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Pla2g12a Lpcat4 Pla2g10 Plaat3 Pla2g5 Lpcat1 Pla2g3 Pla2g6 Mboat2 Pla2g4a Pla2g4b Lpcat3 Lpcat2 Tmem86b Pnpla8 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224217 Collagen degradation Mmp8 Furin Mmp10 Col15a1 Ctsb Col13a1 Col19a1 Phykpl Ctsk Try5 Ctsl Col25a1 Mmp7 Mmp2 Mmp3 Prss3 Mmp9 Tmprss6 Mmp1b Col18a1 Ctsd Mmp20 Col26a1 Mmp12 Mmp13 Mmp14 Mmp15 FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 96%10224871 Fanconi Anemia Pathway Wdr48 Fancl Fancm Slx4 Fanca Uba52 Eme2 Fancb Fancc Eme1 Fance Fancf Fancg Ercc1 Atrip Ercc4 Ube2t Rpa1 Rpa2 Ubb Rpa3 Ubc Faap100 Slx1b Faap24 Faap20 Atr Rps27a Dclre1a Usp1 Dclre1b Fanci Mus81 Fancd2 Haus3 Fan1 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 96%10223425 Synthesis of Leukotrienes (LT) and Eoxins (EX) Alox5ap Mapkapk2 Abcc1 Alox5 Lta4h Alox15 Cyp4f39 Cyp4f1 Cyp4a14 Cyp4f3 Cyp4a12 Cyp4f40 Cyp4b1 Ggt1 Ggt5 Cyp4f4 Cyp4a10 Cyp4a2 Ltc4s Dpep1 Dpep2 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%10223587 Serotonin Neurotransmitter Release Cycle Rims1 Tspoap1 Syn3 Syt1 Syn2 Stx1a Ppfia3 Syn1 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Unc13b Snap25 Slc18a2 Cplx1 Vamp2 Rab3a SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-RNO-9730628.1 Sensory perception of salty taste Scnn1a Scnn1b Scnn1g ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-RNO-68867.1 Assembly of the pre-replicative complex H2ac18 Hist1h2bq H2aj Psma4 Psma3 H3-3b Ube2s Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Orc4 H2bc18 Cdc26 Orc6 Cdc23 Orc1 Orc3 H2az2 Orc2 Cdt1 H2bc4 Psmb5 Gmnn Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Cdc6 Hist1h2ai Mcm7 Psmb1 Mcm8 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Mcm3 Mcm4 Mcm5 Psmc5 Psmc2 Mcm2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Kpnb1 Ubc Kpna6 Ube2e1 Kpna1 Psmb6l1 Psmd7 Psmd6 Psmd8 H2ab2 Psmd2 Psmd1 Adrm1 H2ac4 Cdc16 ENSRNOG00000066901 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224039 Negative regulation of FGFR1 signaling Ppp2cb Ppp2ca Uba52 Frs2 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Ubb Fgf8 Ubc Fgf9 Fgfr1 Fgf17 Braf Ppp2r1a Fgf10 Mapk3 Src Spry2 Mknk1 Cbl Mapk1 Rps27a Grb2 Ptpn11 Fgf20 Kl Fgf23 Fgf22 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 96%10224481 Beta-catenin independent WNT signaling Ctnnb1 Prkcg Wnt5a Gnat2 Prkca Calm3 Gng3 Gng5 Gng4 Dvl1 Dvl2 Wnt11 Gng7 Gnao1 Dvl3 Nlk Gng8 Gngt1 Fzd3 Wnt1 Tcf7l2 Fzd1 Fzd2 Fzd5 Fzd4 Fzd6 Fzd8 Gnb2 Gnb1 Rhoa Gnb4 Gnb3 Gnb5 Gng11 Kras Smurf2 Camk2a Lef1 Map3k7 Arrb2 Daam1 Fzd7 Ppp3ca Ppp3cb Wnt5b Nfatc1 Ror1 Ror2 Ppp3r1 Wnt4 Prickle1 Prkcb Pard6a Rac2 Ap2s1 Pfn1 Ap2a2 Ap2a1 Ap2b1 Rac3 Rac1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Pde6g Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Pde6a Pde6b Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Ap2m1 Clta Psmb6l1 Cltb Cltc Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Smurf1 Gng10-ps1 LDL REMODELING%REACTOME DATABASE ID RELEASE 96%10225367 LDL remodeling P4hb Mttp MITOCHONDRIAL UNCOUPLING%REACTOME%R-RNO-166187.1 Mitochondrial Uncoupling Slc25a14 Ucp1 Ucp2 Ucp3 Slc25a4 Pm20d1 Slc25a27 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223111 FGFR3 ligand binding and activation Fgf16 Fgf17 Fgf18 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Galnt3 Fgf9 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME DATABASE ID RELEASE 96%10224613 SUMOylation of immune response proteins Ikbkg Pias4 Pias3 Ube2i Nfkb2 Sumo2 Ikbke Nfkbia Sumo1 Rela ESTROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223169 Estrogen biosynthesis Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Akr1b10 Cyp19a1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME%R-RNO-69231.1 Cyclin D associated events in G1 Ppp2r2a Ppp2cb Ccnd1 Ppp2ca Uba52 Tfdp2 Tfdp1 Cks1b Cdk7 Cdk6 Rbl2 Rbl1 Mnat1 Ubb E2f1 Ubc E2f2 E2f3 E2f4 E2f5 Cdkn1b Jak2 Rb1 Cdkn1c Ppp2r1b Ppp2r1a Lyn Cul1 Ccnh Cdk2 Src Ccne1 Rps27a Ccne2 Ppp2r3b Cdkn2b Cdkn2d Abl1 Skp2 Cdk4 Skp1 Ccnd2 Ptk6 Ccnd3 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 96%10222701 Conjugation of benzoate with glycine Glyatl3 Acsm2 Glyat PD-1 SIGNALING%REACTOME%R-RNO-389948.1 PD-1 signaling Ywhag Suz12 Ddost Eed Gsk3b Cd274 Os9 Pdcd1 Rnf5 Sel1l Magt1 Rbbp4 Rbbp7 Mib2 Pdcd1lg2 Prkab2 Prkab1 RT1-Db2 Cd3g Cd247 RT1-Db1 Cd3e Cd3d Trav19 AC109737.1 Cd4 RT1-Ha Lck RT1-Ba RT1-Bb ENSRNOG00000065955 Trbv16 RT1-Da H2ab2 H2ac4 ENSRNOG00000066901 Ccnd1 Kmt2a Kmt2c H2ac18 Csk Csnk2a2 Csnk2a1 Hist1h2bq Wdr5 Ash2l Csnk2b H2aj Ptpn6 Psma4 Psma3 H3-3b Hist3h2ba Psma6 Psma5 Psma2 ENSRNOG00000068602 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Ptpn11 H2bc18 H2az2 Skp1 Rbbp5 H2bc4 Psmb5 Hist1h4m Psmb4 H2bc1 Psmb7 Psmb6 Hist1h2ai Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Nek2l1 Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Prkaa1 Derl3 Psmd2 Prkaa2 Derl2 Psmd1 Stt3b Adrm1 Rbx1 Cul1 Erlin2 Spop Erlin1 Vcp Rpn2 Rpn1 Ostc Prkag3 Prkag1 Prkag2 Ost4 Cops5 Tmem258b Tusc3 Cdk4 Cul3 Ezh2 Erlec1 B3gnt3 Dad1 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 96%10222117 Ethanol oxidation Acss1 Aldh1b1 Acss2 Aldh1a1 Adh4 Adh1 Adh7 Adh6 Aldh2 Adh5 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-RNO-964827.1 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 Man1a2 Man1a1 Man1c1 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME%R-RNO-9769743.1 Amplification and propagation of coagulation cascade F10 F11 Gp5 Gp9 Gp1bb Gp1ba Ano6 Proc Pros1 Serpinc1 Serpine2 F9 Serpina5 F2 F8 Serpind1 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 96%10224259 Synthesis of PG Cds2 HCN CHANNELS%REACTOME DATABASE ID RELEASE 96%10224175 HCN channels Hcn3 Hcn4 Hcn1 Hcn2 METABOLISM%REACTOME%R-RNO-1430728.1 Metabolism Cacna1c Cacna1d Adipoq Adipor2 Adipor1 Mlxipl Marcks Pi4kb Pik3c2g Tpte2 Suclg1 Suclg2 Isca2 Pm20d1 Isca1 Trap1 Sdhaf1 Sdhaf2 Sdhaf3 Cs Slc25a27 Nnt Slc25a14 Ucp1 Ucp2 Ucp3 Fh Sdhd Sdhc Sdhb Sdha Aco2 Idh3B Idh3g Sucla2 Idh3a Cd36 Man2b1 Ormdl3 Alad Agpat2 Cpne1 Cpne3 Manba Them4 Degs1 Cyp24a1 Cyp27b1 Chp1 B3galt6 Cemip Fam20b B4galt7 Pxylp1 Chp1l1 Hyal2 Has1 Has2 Has3 Xylt1 Hs3st4 Xylt2 Hs3st1 Hs3st2 Extl2 Hs3st5 Hs3st6 Hs3st3b1 Hs2st1 Ndst1 Ndst2 Ndst3 Plekha6 Ndst4 Hs3st3a1 Plekha5 Hs6st3 Plekha4 Hs6st2 Plekha3 Hs6st1 Plekha2 Plekha1 Ext2 Tnfaip8l2 Ext1 Fdps Tnfaip8l3 Plpp6 Tnfaip8l1 Rufy1 Idi1 Hsd17b7 Pitpnb Inpp5k Mvk Pik3c2b Fdft1 Sqle Bmx Ebp Tnfaip8 Mtmr7 Hmgcs1 Mtmr6 Arv1 Mtmr9 Ggps1 Sc5d Uros Lbr Alas1 Acat2 Alas2 Hmbs Nsdhl Dhcr24 Cpox Dhcr7 Fech Ppox Lss Cox10 Tm7sf2 Cox15 Srebf2 Pmvk Urod Hmgcr Mvd Msmo1 Srebf1 Pcyt2 Cept1 Etnk2 Etnk1 Etnppl Chka Chkb Selenoi Phospho1 Chat B3galt1 Fut2 Fut1 Fut4 B4galnt2 Fut7 Fut9 B3galt5 B3galt4 Abo2 Cyp21 Cyp11b3 Maob Cds1 Cdipt Pitpnm2 Pitpnm3 Pitpnm1 Dcxr Cryl1 Xylb Cyp2w1 Cyp2c24 Aldh2 Aldh1b1 Adh6 Adh5 Cmbl Ephx1 Acy3 Aldh3a1 Aadac Cbr3 Aoc3 Nqo2 Fmo3 Fmo2 Akr7a3 Akr7a2 Cyp11b1 Cyp11b2 Cyp19a1 Abhd10 Acss1 Mtarc2 Bphl Ubiad1 Vkorc1 Ttpa Vkorc1l1 Lpcat4 Lpgat1 Lpcat1 Pla2g3 Crls1 Mfsd2a Pcyt1b Pcyt1a Abhd3 Glul Pemt Chpt1 Stard10 Gpd1l Gnpda1 Abhd4 Osbpl10 Gpi Gnpda2 Miga2 Eno3 Miga1 Gpd1 Eno2 Eno4 Pgp Pfkfb4 Mboat1 Pfkfb3 Mboat2 Pfkfb2 Osbpl5 Pfkfb1 Pld6 Pla1a Pc Pgam2 Osbpl8 Pgam1 Cpne6 Cpne7 Slc37a4 Tpi1 Liph Lipi Slc37a2 Cds2 Slc37a1 Hkdc1 Acp6 Gpat4 Fbp1 Gpat3 Fbp2 Gckr Lpcat3 Lpcat2 Pklr Tmem86b Gapdhs Aldoc Pnpla8 Plaat1 Bpgm Plaat5 Aldoa Agk Pfkl Ddhd2 Pgk2 Agpat4 Pck1 Pfkm Agpat1 Pfkp Pck2 Pgm2l1 G6pc1 Pkml1 Gck Hk2 Hk3 Gc Adpgk A4galt G6pc3 Tpi1l2 Cerk B3galnt1 Ugcg B4galnt1 Ugt8 Sirt3 Gal3st1 Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Pld1 Man2c1 Stard4 Star Stard6 Cyp11a1 Tspo Psma4 Fdx2 Fdxr Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Glrx5 Plcb4 Plcb3 Pla2g4a Plcb2 Plcb1 Nudt9 Nudt16 Gda Gng10-ps1 Nudt18 Adprm Nt5c Nt5c1a Nt5c1b Nt5e Nudt1 Nt5c2 Itpa Dnph1 Adcy5 Nudt5 Adcy6 Dsel Ust Dse Cspg5 Bgn Prkaca Prkacb Cspg4 Chst14 Chst15 Idua Hyal4 Gnai2 Hyal3 Gnai1 Prkca Ids Hyal1 Gna11 Gusb Prkar1a Gna14 Prkar1b Calm3 Gng3 Pomc Gng5 Gng4 Gnaq Gng7 Gng8 Gngt1 Prkar2a Prkar2b Gnb2 Gnb1 Gnb4 Gnb3 Odc1 Gnb5 Oaz1 Gng11 Oaz3 Oaz2 Nqo1 Azin1 Slc6a7 Slc6a11 Slc25a18 Slc25a22 Adra2a Ca1 Ca2 Ca4 Adra2c Rnf113a1 Crebbp Gale Galt Sin3a Sin3b Galm Csnk2a2 Galk1 Ctsl Csnk2a1 Mfsd2b Sptssa Csnk2b Cers6 Cers5 Cers4 Cers3 Cers2 Sgms1 Sgms2 Sptlc1 Sptlc2 Sptlc3 Fa2h Sphk2 Spns2 Kdsr Degs2 Ormdl2 Smarcd3 Cidea Cidec Ca12 Ca14 Ca13 Ca3 Ca6 Ca9 Ca5b Ca5a Hsd17b13 Fitm2 Fitm1 St8sia5 Car7 Neu2 Neu3 Neu4 Neu1 St6galnac5 St6galnac6 Slc17a5 St3gal6 St3gal4 St3gal5 St3gal2 St3gal3 St3gal1 Glb1 Ctsa Adhfe1 L2hgdh D2hgdh Prkaa2 Prkag2 B3gnt3 Prkab2 Echs1 Hadh Ecsit Cbr1 Tbxas1 Ptges Ptgds Ptgis Ptges2 Ptgs1 Mapkapk2 Nosip Akt1 Sbf1 Itpk1 Rab5a Rab4a Plcg2 Mgll Pik3r6 Rab14 Gamt Ckmt1 Ckmt2 Gatm Slc6a8 Ckm Slc6a12 Ckb Dguok Gmpr2 Pnp Ampd3 Ampd2 Itpr3 Ampd1 Adk Itpr2 Itpr1 Gmpr Hprt1 Dck Aprt Ada Slc3a2 Lhb Cga Slc7a5 Ces1d Hadha Hadhb Acadl Glyatl3 Acsm2 Acsm4 Acsm5 Glyat Gstm4 Ltc4s Inpp5d Pik3ca Pik3r1 Pik3cb Pik3r2 Pik3r3 Inppl1 Pik3cd Pik3r5 Pik3cg Alox12 Cyp3a9 Alox5ap Gpx4 Hpgd Alox5 Lta4h Alox15 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Ephx2 Cyp3a1 Cyp1a2 Cyp2d4 Cyp3a62 Pnpla2 Cyp3a2 Mbtps1 Ptgs2 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Tgs1 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 Sult1e1 Tpst1 Nup133 Nup210 Tpst2 Sult2b1 Nup155 Sult1a1 Nup153 Sult1c2 Sult1b1 Bpnt2 Akr1c18 Sult6b1 Akr1c12l1 Sult4a1 Akr1c19 Sult2a2 Bpnt1 Ugt1a2 Ugt1a3 Sult2a1 Ugt1a5 Sult2a6 Abhd14b Akr1c21 Podxl2 Ugt2b1 Naglu Hpse2 Hsd11b1 Hsd11b2 Hpse Ugt2b7 Sgsh AC114845.1 Smox Ugt2b34l1 Sat1 Ugt2b Serpina6 Shmt2 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Alb Ugt2b17 Ugt2b37 Ugt2b15 Akr1c9 Cacnb3 Cacna1e Cacnb2 Cacna1a Mtmr1 Cacna2d2 Apoc2 Apoa1 Apoc3 Apoa2 Apoe Apoa4 Apob Ndufs3 Ocrl Pld2 Ndufa5 Ptpn13 Nampt Shmt1 Ldlrap1 Pdxk Naxe Slc52a2 Slc52a3 Lrpl1 Mccc1 Btd Mccc2 Acacb Slc25a51 Acaca Aasdhppt Dhfr Fasn Slc19a1 Slc25a42 Slc5a6 Slc5a8 Gcgr Bst1 Vnn1 Cblif Tcn2 Fpgs Mmut Mthfs Cubn Mthfr Slc25a32 Slc46a1 Slc23a1 Mthfd1l Slc23a2 Naprt Mmadhc Pcca Rfk Pccb Acp5 Aox1 Slc2a1 Slc2a3 Nadk2 Nudt12 Gcg Mthfd2l Amn Nmrk1 Mocs3 Slc25a16 Hlcs Aldh1l1 Aldh1l2 Cd38 Nadsyn1 Pnpo Nadk Cyb5r3 Nmnat1 Mmaa Flad1 Mmab Rnls Enpp1 Mocs1 Mmachc Slc22a13 Nfs1 Naxd Nmnat3 Nmnat2 Qprt Mthfd1 Mthfd2 Folr2 Gphn Pank4 Mocos Ffar1 Gnas Psap Glp1r Vdr Ppara Tshb Scly Mat1a Grhpr Aldh4a1 Got2 Amt Gnmt Agxt2 Prodh2 Mpst Usf1 Sqor Ethe1 Fmo1 Mri1 Suox Ado Txn2 Bhmt Mtap Enoph1 Tst Adi1 Bhmt2 Gadl1 Cdo1 Slc25a10 Pip4k2b Pip4k2c Pip4k2a Pip5k1a Got1 Mdh1 Mdh2 Slc25a11 Slc25a12 Slc25a13 Chst11 Chst12 Chsy1 Chsy3 Chst13 As3mt Chpf Ahcy Csgalnact2 Comt Chst7 Mtrr Chst9 Gsto1 Tpmt Mat2a Mat2b Mtr Ranbp9 B3gnt5 Prkg2 Lypla1 Rap1a Slc26a2 Slc26a1 Slc35b3 Slc35b2 Papss2 Papss1 Slc26a11 Ran Gpx2 Aloxe3 Gpx1 Alox12b Cyp2s1 Miox Ip6k3 Isyna1 Itpka Itpkc Itpkb Impa2 Impa1 Inpp5a Inpp5b Plch1 Pld4 Plcd1 Plcd4 Inpp5j Plcd3 Nudt4 Nudt3 Synj1 Tkfc Plcz1 Aldh1a1 Plce1 Glyctk Inpp1 Sord Ppip5k1 Aldob Ppip5k2 Akr1b1 Khk Mt-atp6 Atp5mc1 Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Rrm2b Atp5pf Txnrd1 Atp5mf Dtymk Atp5me Nudt13 Dmac2l Dut Atp5mg Rrm1 Atp5f1b Tyms Atp5f1a Rrm2 Atp5po Ak1 Atp5mk Gsr Mt-atp8 Nme3 Ak2 Nme2 Ak5 Glrx Ak4 Ak7 Ak6 Ak9 Nme1 Cmpk1 Dctd Ak8 Nme6 Ctps2 Ctps1 Acoxl Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc44a2 Slc35d1 Slc22a5 Slc22a4 Pgk1 Sephs2 Gstz1 Gsta5 Gsta6 Gsta3 Gsta1 Gsta2 Chac1 Chac2 Gstm7 Gstm5 Gstk1 Ggct Gstm1 Gclc Gstm2 Mgst3 Gsto2 Esd Cndp2 Mgst2 Mgst1 Gclm Ggt1 Ggt5 Ggt7 Slc9a1 Ggt6 Hpgds Gss Gstp1 Gstt2 Akr1a1 Gstt1 Oplah Slc2a2 Slc36a4 Pias4 Ube2i Slc25a4 Mecr Mtmr14 Mtmr3 Pgam5 Lgmn Sumo3 Prodh Aanat Tph2 Duox1 Tph1 Ddc Pnmt Duoxa1 Duoxa2 Cav1 Asmt Txndc11 Dio1 Dio2 Dio3 Dbh Duox2 Tpo Th Iyd Slc5a5 Gls Dmgdh Tdo2 Tyrp1 Ido2 Hpd Ido1 Slc45a2 Pycr3 Pycr2 Pycr1 Glud1 Aldh6a1 Kyat1 Dhtkd1 Asl Tyr Hal Hykk Pah Acadsb Gpt Phgdh Auh Aadat Agmat Slc25a21 Gcdh Folh1 Arg2 Arg1 Slc25a15 Ivd Aass Oca2 Oat Hdc Bbox1 Aoc1 Fah Asrgl1 Slc25a2 Amdhd1 Aldh9a1 Hsd17b10 Acat1 Serinc4 Serinc5 Serinc2 Aldh18a1 Hgd Serinc1 Haao Gpt2 Kmo Acad8 Carns1 Sirt5 Naalad2 Cps1 Qdpr Hibadh Azin2 Psph Rimkla Rimklb Tat Amd1 Asns Aldh7a1 Nat8l Bcat1 Bcat2 Hibch Pcbd1 Carnmt1 Bckdhb Dct Bckdha Crym Gls2 Psat1 Srm Il4i1 Srr Aspg Nags Aspa Bckdk Tmlhe Uroc1 Chdh Ftcd Kynu Sardh Ppm1k Abcc5 Tymp Upb1 Upp1 Nt5c3a Upp2 Pip5k1b Dpys Dpyd Nt5m Ugt1a6 Ugt1a7 Ugt1a8 Nat1 Dnm2 Nat2 Nat3 Ugt2a1 Ugt2a3 Gmps Ces2h Pon3 Impdh2 Pon1 Acy1a Impdh1 Ugt3a1 Txn Hsp90ab1 Cycsl2 Slc35d2 Glb1l B3gnt7 B3gnt2 Kera Idh2 Gns B4galt4 B4galt5 B4galt6 Acss2 Prelp Glb1l3 Cycs Glb1l2 Fmod Galns Hexa Hexb B4gat1 Lum Omd Chst1 Chst3 Chst2 B4galt2 B4galt3 Acan Chst6 Ogn Plcg1 Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Plbd1 Pla2r1 Mt-cyb Pla2g12a Mboat7 Pla2g10 Plaat3 Pla2g5 Pdhx Hsp90aa1 Cyp26b1 Pdk4 Pdk3 Pdk2 Pdk1 Pdhb Rxra Cyp26a1 Sphk1 Rdh11 Tbl1x Adh4 Pdha1 Adh1 Pdha2 Hdac3 Tbl1xr1 Zdhhc21 Ppard Ptges3 Mt-co3 Dld Mt-co2 Ncor2 Carm1 Nos3 Fabp5 Cyp26c1 Mt-co1 Mt-nd5 Dlat Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 Tafazzin Lclat1 Higd1c Arf3 Arf1 Cox7a1 Cox7a2 Cox7a2l AC132020.1 Ogdh Dlst Kgd4 Gch1 Idh1 Pdss2 Coq8a Pdss1 Coq8b Coq2 Pts Coq3 Gchfr Coq4 Coq5 Coq6 Hpdl Coq7 Spr Coq9 Stard7 Aco1 Morc2 Hyal5 Ndufa4 Cox6a1 Cox6a2 Cox6c2 Cox6b1 Cox6b2 G6pdx Entpd1 Pip4p1 Entpd2 Entpd5 Entpd6 Entpd3 Cox8a Entpd4 Entpd7 Cox8c Entpd8 Cox7b Cox7c Slco1a4 Slco1b2 Slco2b1 Cox5a Cox5b Phyh Amacr Eci2 Hmox1 Hacl1 Mlycd Scp2 Gnpat Crat Acox1 Acox2 Ehhadh Acox3 Pipox Acaa1b Hsd17b4 Cox4i1 Cox4i2 Hao1 Hao2 Pecr Dao Acbd5 Slc27a2 Aldh3a2 Decr2 Crot Nudt19 Acot1 Acot2 Cygb Acot5 Acot3 Acot4 Cyb5a Acot8 Fxn Abcd1 Baat Ddo Agps Agxt Hmgcl Hscb Ndufb8 Ldhal6b Glo1 Wdr26 Hagh Nek1 Otc Mkln1 Fahd1 Kpnb1 Gid4 Maea Ldha Ldhb Ldhc Armc8 Me1 Me3 Me2 Rmnd5b Ddah1 Nostrin Cyb5b Cox18 Tmem177 Cox20 Ch25h Uxs1 Osbpl3 Ugp2 Osbpl2 Osbpl1a Ugdh Osbpl7 Osbpl6 Cyp39a1 Osbpl9 Hsd3b7 Ncoa2 Akr1d1 Cyp8b1 Cyp7b1 Slc10a1 Alpi Fabp6 Nr1h4 Abcc3 Stard5 Cyp46a1 Cyp27a1 Osbp Slc27a5 Slc51a Cyp7a1 Slc51b Abcb11 Synj2 Ippk Ipmk Ip6k1 Ip6k2 Inpp5f Pi4k2b Inpp4a Pikfyve Inpp4b Pik3c2a Pik3c3 Mtm1 Fig4 Agpat3 Vac14 Mtmr12 Pi4k2a Mtmr4 Pik3r4 Gcsh Ndufab1 Fdx1 Dbt Awat2 Awat1 Dhrs7b Far2 Far1 Pla2g6 Bcan Vcan Agrn Ncan Dcn Cyp2j16 Adh7 Cyp4f39 Cyp2j3 Cyp4f1 Cyp4a14 Cyp2f2 Cyp4f3 Cyp4a12 Cyp4f40 Cyp4b1 Cyp2a2 Cpt1a Cyp2a1 Mid1ip1 Thrsp Cyp4f4 Cpt2 Cyp4a10 Cpt1b Cyp4a2 Cyp2a3 Slc25a20 Kcnb1 Kcns3 Kcnc2 Kcng2 M6pr Sacm1l Pi4ka Ppa1 Ppa2 Lhpp Abcc8 Kcnj11 Rida Sds Sdsl Arsa Smpd2 Cyp1b1 Smpd3 Smpd4 Smpd1 Gba1 Gba3 Cyp4v2 Gba2 Enpp7 Galc Asah2 Asah1 Sts Gm2a Arsl Arsk Arsj Arsi Arsg Gla Sumf1 Arsb Sumf2 Hspa9 Pip5k1c Med1 Plekha8 Pank3 Pank2 Pank1 Ppcs Dcakd Ppcdc Coasy Pdp1 Pdpr Pdp2 Fabp1 Blvrb Hmox2 Blvra Abcg2 Abcc1 Abcc2 Ugt1a1 Hsd3b Hsd17b3 Cyp17a1 Atic Adsl Hsd3b6 Hsd3b5 Ppat Adss2 Srd5a3 Pfas Hsd3b1 Paics Srd5a1 Gart Hsd17b12 Adss1 Srd5a2 Hsd3b5-ps1 Lpin3 Lpin2 Arnt2 Arnt Ahrr Ahr Lrp1 Sdc4 Sdc3 Sdc2 Lpl Gpihbp1 Lrp8 Lrp2 Lrp10 Plb1 Lrp12 Ttr Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Bco2 Bco1 Gpc6 Clps Pnlip Akr1b10 Rbp4 Apom Dgat2l6 Rbp2 Rbp1 Dgat2 Dgat1 Sdc1 Lrat Pnpla3 Minpp1 Cbs Cth Rapgef4 Rapgef3 Xdh Phykpl Cd44 Cyp2u1 Hacd1 Hacd2 Hacd3 Hacd4 Hsd17b8 Dpep1 Dpep2 Mcat Acad11 Elovl2 Acly Elovl3 Acaa2 Elovl5 Elovl1 Elovl6 Elovl7 Tecrl Faah Acbd6 Acbd4 Ppt2 Ppt1 Acsf3 Acsf2 Dbi Acot11 Scd1 Acot12 Acot13 Them5 Acot9 Acot7 Acsl1 Acsl5 Acsl6 Acsl3 Acsl4 Fads2 Pon2 Fads1 Acadvl Alox15b Cbr4 Tecr Acsbg1 Pctp Acads Acsbg2 Scap Fabp2 Fabp3 Fabp4 Gk Fabp7 Mogat1 Pnpla5 Gpat2 Pnpla4 Mogat2 Vdac1 FABP12 Gpam Gpd2 Agmo Fabp9 Gykl1 Rpe Taldo1 Prps1l3 Pgd Prps1 Rpia Dera Prps2 Shpk Pgm2 Pgls Tkt Rbks Cda Umps Cad Samhd1 Pudp Dhodh Tk2 Uck1 Uck2 Oxct2a Acss3 Bdh2 Bdh1 Oxct1 Hmgcll1 Hmgcs2 Aacs Ndufaf7 Ndufaf6 Ndufaf5 Ndufaf4 Tmem186 Ndufaf3 Ndufaf2 Ndufaf1 Tmem126b Uqcrfs1 Nubpl Iscu Acad9 Etfdh Coq10a Coq10b Uqcrq Cyc1 Ndufv2 Ndufv1 Ndufv3 Uqcrb LOC120097699 Uqcrh Ndufc2 Ndufa12 Ndufa11 Pten Ndufa10 Ndufs1 Timmdc1 Ndufa13 Ndufs2 Ndufs5 Ndufs4 Ndufs7 Eci1 Ndufs6 Acadm Ndufs8 Decr1 Acer1 Ndufa6 Acer2 Ndufa9 Aldh3b1 Ndufa8 Ndufb11 Sgpl1 Ndufb10 Aldh3b2 Acer3 Ndufb1 Lyrm7 Sgpp2 Ndufb3 Plpp2 Plpp3 Hccs Uqcrc2 Plpp1 Uqcrc1 Sgpp1 Etfb Lyrm4 Ndufb5 Etfa Lyrm2 Ndufb7 Dmac2 Maoa Dmac1 Tspoap1 Ndufa3-ps3 Uqcr10 Ttc19 Inpp5e Slc25a19 Thtpa Tpk1 Slc19a2 Slc19a3 Phkg1 Gaa Gbe1 Phkg2 Agl Pygl Pygm Phkb Ppp1r3c Gys1 Akr1e2 Phka1 Phka2 Gyg1 Pgm1 Ptdss1 Ptdss2 Pla2g15 Pla2g4b Gde1 Pnpla6 Enpp6 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME%R-RNO-9943962.1 CHD6, CHD7, CHD8, CHD9 subfamily Hist1h2ai H2aj Fam124b H2ab2 Ctnnb1 H3-3b Hist3h2ba H2ac4 H2ac18 ENSRNOG00000068602 Ctcf H2bc18 Chd6 Chd7 H2az2 Hist1h2bq ENSRNOG00000066901 H2bc4 Chd8 Hist1h4m H2bc1 Wdr5 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-RNO-159763.1 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Pros1 F10 F7 F9 Bglap Gas6 F2 Proc Proz CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-RNO-1834949.1 Cytosolic sensors of pathogen-associated DNA Stat6 Ikbkg Mre11 Uba52 Aim2 Nfkb2 Nfkb1 Crebbp Ctnnb1 Trim32 Rela Nlrp4 Dtx4 Dhx9 Myd88 Ubb Ubc Dhx36 Nfkbib Tbk1 Irf3 Nfkbia Ddx41 Ep300 Rps27a Sting1 Nkiras1 Chuk Ikbkb Irf7 Nkiras2 Trim21 APAP ADME%REACTOME%R-RNO-9753281.1 APAP ADME Sult1a1 Abcg2 Abcc1 Sult2a2 Abcc2 Ugt1a1 Sult2a1 Abcc3 Sult2a6 Cyp2e1 Ugt1a6 Ugt1a7 Cndp2 Ugt1a8 Nat1 Nat2 Ggt1 Nat3 Ggt5 Ggt7 Ggt6 Gstp1 Acy1a Ugt2b15 Gstt1 Abcc4 Abcc5 Sult1e1 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME DATABASE ID RELEASE 96%10224211 Downregulation of ERBB2:ERBB3 signaling Rps27a Rnf41 Erbb2 Erbb3 Uba52 Nrg2 Akt3 Ubb Akt2 Akt1 Ubc Usp8 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-RNO-1606341.1 IRF3 mediated activation of type 1 IFN Irf3 TRNA PROCESSING%REACTOME%R-RNO-72306.1 tRNA processing Yrdc Qng1 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 96%10223855 Miscellaneous transport and binding events Azgp1 Lrrc8e Dmtn Lrrc8a Lrrc8b Nipa1 Lrrc8c Magt1 Nipa2 Lrrc8d Rhag Rhcg Rhbg Slc66a1 Pip Add1 Add3 Tusc3 Ctns Nipal4 Nipal2 Add2 Ankh Mrs2 Nipal3 Nipal1 TRIGLYCERIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222299 Triglyceride biosynthesis Agmo Dgat2 Gykl1 Dgat1 Gk Lpin3 Mogat1 Lpin2 Gpat2 Mogat2 Gpam RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 96%10224805 RHO GTPases Activate Rhotekin and Rhophilins Rtkn Rhpn1 Rhpn2 Lin7b Rhoa IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 96%10224051 IRAK1 recruits IKK complex Peli1 Peli2 Ikbkg Peli3 Ube2n Chuk Ikbkb Irak1 Traf6 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223387 Thyroxine biosynthesis Duox1 Duoxa1 Duoxa2 Cav1 Txndc11 Dio1 Dio2 Dio3 Cga Duox2 Tpo Iyd Slc5a5 Tshb SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-RNO-446199.1 Synthesis of dolichyl-phosphate Dhdds Srd5a3 Mvd Dolpp1 Dolk Dhrsx Nus1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 96%10222767 Class B 2 (Secretin family receptors) Pthlh Iapp Adm Gng3 Ramp1 Gng5 Vip Gng4 Gng7 Calcr Gng8 Gngt1 Ucn2 Ucn3 Gnb2 Gnb1 Crhr2 Gnb4 Crhr1 Gnb3 Calcb Gnb5 Gng11 Calca Gipr Gnas Calcrl Pth1r Sct Pth Ucn Gcgr Sctr Adcyap1 Crhbp Ghrh Pth2r Gcg Gip Ghrhr Ramp3 Glp1r Ramp2 Crh Gng10-ps1 Adgre5 Adgre1 Vipr2 Adm2 Pth2 Vipr1 Glp2r Cd55 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222501 PKA activation Adcy5 Adcy6 Adcy9 Prkar2a Prkar2b Prkaca Prkacb Prkar1a Prkar1b Calm3 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-RNO-196299.1 Beta-catenin phosphorylation cascade Ppp2r5b Ppp2r5a Ppp2cb Ppp2ca Gsk3b Ppp2r1b Apc Ppp2r1a Ctnnb1 Frat2 Frat1 Csnk1a1 Ppp2r5e Amer1 Ppp2r5d Axin1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 96%10222837 Toll Like Receptor 10 (TLR10) Cascade Ppp2cb Ppp2ca Tlr10 Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 MRNA EDITING: A TO I CONVERSION%REACTOME%R-RNO-75064.1 mRNA Editing: A to I Conversion Adarb1 Adar INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-RNO-400508.1 Incretin synthesis, secretion, and inactivation Ffar4 Dpp4 Gpr119 Lep Gcg Ffar1 Gip Grp MITOCHONDRIAL ABC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%10223605 Mitochondrial ABC transporters Abcb6 Abcb7 Abcb8 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-RNO-157858.1 Gap junction trafficking and regulation Gja10 Gjc1 Gjd2 Gjd4 Gjb2 Gjd3 Gjb1 Gjc2 Tjp1 Gja3 Gjb4 Gjb3 Gja5 Gjb6 Gjb5 Gja4 Gja8 Dnm2 Ap2m1 Gja1 Clta Cltb Myo6 Cltc Dab2 Dnm1 Src FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 96%10222535 Formation of apoptosome Mapk1 Apip Cycsl2 Diablol1 Casp9 Apaf1 Cycs Xiap Mapk3 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%10223597 Transcriptional regulation of white adipocyte differentiation Pparg Ncor2 Hdac3 Rxra TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-RNO-171319.1 Telomere Extension By Telomerase Acd Terf1 Shq1 Dkc1 Nhp2 Pif1 Terf2ip Gar1 Wrap53 Tinf2 Rtel1 Pot1 Nop10 Ccna1 Ccna2 Cdk2 Ppp6r3 Ankrd28 Ppp6c Tert Terf2 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%10223313 Apoptotic cleavage of cellular proteins Ocln Casp7 Apc Mapt Tjp1 Ctnnb1 Prkcq Prkcd Birc2 Dsg3 Cdh1 Plec Dsp Casp3 Bcap31 Dsg1 Gsn Dsg2 Casp6 Satb1 Gas2 Sh3glb2 Add1 Rock1 Clspn Tjp2 Casp8 Ptk2 Stk26 Sptan1 Stk24 Pkp1 Lmna Bmx Lmnb1 Fnta Acin1 Vim ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 96%10223959 Acetylcholine binding and downstream events Chrnb4 Chrnb3 Chrnb2 Chrnd Chrne Chrna3 Chrng Chrna2 Chrna1 Chrna7 Chrna6 Chrna5 Chrna4 Chrna9 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223097 FGFR1b ligand binding and activation Tgfbr3 Gipc1 Fgf2 Fgf1 Fgf3 Fgf10 Fgf22 Fgfr1 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-RNO-2559582.1 Senescence-Associated Secretory Phenotype (SASP) Ehmt1 Cdk6 H2ac18 Hist1h2bq H2aj Ccna1 H3-3b Ccna2 Mapk3 Ube2s Hist3h2ba ENSRNOG00000068602 Rps27a Ube2c Cdkn2b Cdkn2d Cdc27 H2bc18 Cdc26 Cdc23 H2az2 Mapk7 H2bc4 Hist1h4m H2bc1 Hist1h2ai Uba52 Anapc10 Ube2d1 Anapc16 Anapc15 Rps6ka3 Rps6ka1 Rps6ka2 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Cebpb Ube2e1 Cdkn1b H2ab2 Cdk2 H2ac4 Cdc16 Mapk1 ENSRNOG00000066901 Cdk4 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-RNO-162658.1 Golgi Cisternae Pericentriolar Stack Reorganization Mapk1 Golga2 Plk1 Gorasp1 Rab2a Blzf1 Rab1A Rab1b Mapk3 Gorasp2 RHOBTB1 GTPASE CYCLE%REACTOME%R-RNO-9013422.1 RHOBTB1 GTPase cycle Cpsf7 Myo6 Txnl1 Pde5a Stk38 Rbbp6 Cct7 Rnf20 Cops4 Cops2 Spen Gps1 Hnrnpc Rbmx Tra2b Cct2 Cul3 Vim Rhobtb1 Rock2 Rock1 Srrm1 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-RNO-391903.1 Eicosanoid ligand-binding receptors Ptgdr2 Ptger2 Ptger3 Ptger1 Cysltr2 Cysltr1 Ltb4r Gpr17 Ptgdrl Tbxa2r Ptgir Ltb4r2 Ptgdr Ptger4 Ptgfr REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 96%10224607 Regulation of FZD by ubiquitination Uba52 Fzd5 Lgr5 Fzd4 Lgr6 Fzd6 Fzd8 Rps27a Znrf3 Rspo1 Rspo3 Rspo2 Rspo4 Ubb Ubc Rnf43 Lrp6 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME DATABASE ID RELEASE 96%10225417 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Uba52 Tbk1 Ikbke Optn Rps27a Traf3 Tank Ly96 Ticam2 Ubb Ubc Ticam1 Cd14 Tlr4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-RNO-927802.1 Nonsense-Mediated Decay (NMD) LOC120093247 Ppp2ca Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Magohb Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Ppp2r1a Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Ncbp2 Ncbp1 Rpl23a Upf3b Upf3a Eif4a3 Smg1 Smg9 Smg8 Smg7 Smg6 Smg5 Upf1 Upf2 Rbm8a Casc3 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Pabpc1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Ppp2r2a Rps4x-ps13 Rpl38 Rps3a Etf1 Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Pnrc2 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rnps1 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Magoh Rpl12-ps1 Ubc Rps20 Rps21 Dcp1a Rpl22 Rps23 Rps24 Rpl23 Gspt2 Gspt1 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 INTERLEUKIN-12 SIGNALING%REACTOME%R-RNO-9020591.1 Interleukin-12 signaling Vamp7 Il12a P4hb Jak2 Tyk2 Il12rb1 Il12rb2 Il12b REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 96%10224549 Regulation by c-FLIP Ripk1 Tnfsf10 Casp8 Fas Fadd Faslg Traf2 Tradd Cflar REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 96%10224149 Reversible hydration of carbon dioxide Ca5a Car7 Ca12 Ca1 Ca14 Ca2 Ca13 Ca3 Ca4 Ca6 Ca9 Ca5b TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME DATABASE ID RELEASE 96%10223913 TRAF6-mediated induction of TAK1 complex within TLR4 complex Map3k7 Uba52 Irak2 Rps27a Tab3 Tab2 Tab1 Ly96 Ticam2 Ubb Sarm1 Ubc Ticam1 Cd14 Traf6 Tlr4 NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 96%10222061 Neuronal System Gls2 Cacnb3 Cacnb4 Creb1 Cacnb1 Cacna1e Cacnb2 Stx1a Cacna1a Cacna1b Cacna2d3 Cacng4 Flot2 Cacna2d2 Cacng2 Flot1 Ntrk3 Vamp2 Lin7b Rps6ka3 Rps6ka1 Rps6ka2 Panx1 Slitrk5 Slitrk3 Cacng8 Cacng3 Chrnb4 Chrnb3 Chrnb2 Grip2 Prkcb Epb41l1 Gabrg2 Gabrg3 Grin3a Chrna3 Chrna2 Ap2s1 Chrna1 Chrna7 Grik5 Chrna6 Chrna5 Chrna4 Grik4 Ap2a2 Ap2a1 Chrna9 Grik3 Ap2b1 Pick1 Gabra4 Gabra3 Gabra6 Gabra5 Gabra2 Gabra1 Akap5 Glra3 Gja10 Glra2 Gjc1 Glra1 Gjd2 Rps6ka6 Tspan7 Camk1 Shank1 Glrb Shank3 Ncald Homer1 Grip1 Homer2 Chrnd Gabrr1 Nrxn1 Chrne Nrxn2 Gabrr3 Nrxn3 Gabrr2 Epb41 Chrng Epb41l2 Gabrq Epb41l3 Gabrb1 Epb41l5 Gabrb3 Lrrtm1 Slc18a3 Gabrb2 Lrrtm2 Lrrtm3 Htr3b Lrrtm4 Htr3a Dlgap1 Homer3 Dlgap4 Dlgap3 Dlgap2 Nlgn2 Nlgn1 Nlgn3 Lrrc4b Il1rapl1 Ptprf Il1rapl2 Gabbr1 Slitrk6 Slitrk4 Slitrk1 Slitrk2 Gabbr2 Ppfibp2 Ppfibp1 Dnajc5 Kcnd3 Kcnd2 Kcnd1 Kcnab2 Hspa8 Rab3a Slc5a7 Lrfn2 Rtn3 Lrfn3 Lrfn4 Lrfn1 Ptprs Kcnb2 Kcnh8 Kcnh7 Kcnh6 Kcnh5 Kcnh4 Kcnf1 Kcnh3 Kcnq5 Gng10-ps1 Adcy3 Kcnk13 Kcnab1 Adcy4 Kcns2 Adcy1 Kcns1 Adcy2 Kcnab3 Kcna7 Camkk1 Kcna6 Adcy7 Kcna4 Camkk2 Kcna3 Adcy8 Kcna10 Kcna2 Adcy5 Kcnb1 Adcy6 Kcns3 Kcnc4 Kcna1 Kcnc2 Tomt Kcnc3 Kcng2 Adcy9 Kcnc1 Kcng4 Kcng3 Kcng1 Prkaca Kcnh1 Prkacb Prkcg Kcnv2 Kcnv1 Gnai2 Gnai1 Prkca Slc1a1 Gnai3 Camk4 Prkar1a Slc38a2 Prkar1b Slc1a7 Calm3 Slc1a6 Nsf Gng3 Gnal Kcna5 Sh3glb2 Gng5 Slc6a12 Gng4 Kcnq1 Il1rap Gng7 Kcnh2 Gng8 Gngt1 Kcnj9 Kcnj8 Gnat3 Prkar2a Kcnj6 Prkar2b Kcnj5 Kcnj4 Kcnj3 Kcnj10 Kcnj2 Kcnj1 Gnb2 Kcnj14 Abcc8 Gnb1 Kcnj11 Gnb4 Kcnj12 Abcc9 Grin2a Gnb3 Lrrc7 Gnb5 Kcnj15 Gng11 Gria4 Kcnj16 Slc22a2 Gria3 Camk2g Camk2d Slc22a1 Gria2 Slc32a1 Camk2b Dlg1 Dlg2 Gria1 Actn2 Slc6a11 Dlg3 Slc6a13 Dlg4 Camk2a Nefl Grin1 Aldh5a1 Grik2 Grin2d Grik1 Grin2c Slc17a7 Naaa Abat Grin2b Slc6a1 Syn3 Slc6a4 Syn2 Slc6a3 Syn1 Cask Chat Panx2 Lin7a Lin7c Gad1 Gad2 Apba1 Arl6ip5 Grm1 Grm5 Rims1 Maoa Tspoap1 Syt1 Ppfia3 Ppfia2 Ppfia4 Ppfia1 Stxbp1 Unc13b Snap25 Slc18a2 Cplx1 Kcnmb1 Kcnmb2 Kcnmb3 Kcnmb4 Kcnn4 Kcnn3 Kcnn2 Hcn3 Hcn4 Kcnma1 Hcn1 Hcn2 Aldh2 Kcnk4 Kcnk2 Kcnk1 Kcnk10 Kcnk16 Kcnk9 Kcnk7 Kcnk18 Kcnk6 Arhgef9 Gls Slc38a1 Ap2m1 Slc1a3 Slc1a2 Glul Myo6 Comt PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 96%10221941 Processive synthesis on the lagging strand Fen1 Pold2 Pold1 Pcna Pola2 Pola1 Pold4 Pold3 Prim2 Prim1 Rpa1 Rpa2 Rpa3 Lig1 Dna2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 96%10222379 RNA Polymerase III Transcription Initiation From Type 3 Promoter Bdp1 Tbp Snapc3 Snapc4 Snapc1 Snapc2 Polr3gl Crcp Polr3a Brf2 Polr3d Polr1c Polr3e Polr3b Polr3c Polr2h Polr3f Polr3g Polr2e Pou2f1 Polr2f AGMATINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223477 Agmatine biosynthesis Agmat Azin2 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-RNO-111932.1 CaMK IV-mediated phosphorylation of CREB Camk4 Calm3 Camkk1 Camkk2 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME DATABASE ID RELEASE 96%10224141 Cross-presentation of particulate exogenous antigens (phagosomes) Cyba Ncf4 Cybb Cd36 Itgav Ncf1 Ncf2 RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-RNO-159418.1 Recycling of bile acids and salts Ncoa2 Baat Slc10a1 Fabp6 Nr1h4 Abcc3 Stard5 Slc27a5 Slc51a Slc51b Abcb11 Alb Slco1a4 Slco1b2 Rxra LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME%R-RNO-380284.1 Loss of proteins required for interphase microtubule organization from the centrosome Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Pafah1b1 Dync1h1 Csnk1d Ccp110 Dync1i2 Nde1 Nedd1 Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Cep57 Nek2l1 Pcm1 Ssna1 Clasp1 Tubg1 Ywhae Cep63 Cep152 Tuba4a Plk1 Haus4 Haus5 Haus6 Pcnt Sfi1 Haus1 Cdk1 Mapre1 Cep250 Dynll1 Cep290 Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Odf2 Ckap5 Alms1 Csnk1e Cetn2 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME DATABASE ID RELEASE 96%10224883 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Ccnb1 Gadd45a Pcna Sfn Cdk1 Aurka Bax FORMATION OF THE EDITOSOME%REACTOME DATABASE ID RELEASE 96%10222367 Formation of the Editosome Apobec1 A1cf Apobec4 Apobec2 Apobec3 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 96%10224903 TP53 Regulates Transcription of Cell Death Genes Igfbp3 Tmem219 Steap3 Cradd Pidd1 Casp2 Rabggta Bnip3l Rabggtb LOC134478826 Atm Chm DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 96%10224261 Degradation of DVL Psmb6 Dact1 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Hecw1 Klhl12 Ubb Ubc Dvl1 Dvl2 Psmb6l1 Dvl3 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cul3 Psmb5 Psmb4 Psmb7 NEUROTRANSMITTER CLEARANCE%REACTOME%R-RNO-112311.1 Neurotransmitter clearance Slc22a2 Maoa Tomt Slc6a4 Slc22a1 Slc6a3 Comt Aldh2 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME DATABASE ID RELEASE 96%10222951 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase Cdc14a Anapc10 Ube2d1 Anapc16 Ube2s Cdc16 Anapc15 Ube2c Anapc5 Anapc4 Cdc27 Anapc1 Cdc26 Anapc2 Cdc23 Fzr1 Anapc7 Cdc20 Ube2e1 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 96%10225019 Lipid particle organization Hsd17b13 Fitm2 Fitm1 Cidea Cidec REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%10221989 Regulation of TP53 Activity through Phosphorylation Rhno1 Dyrk2 Rad50 Prkab2 Prkab1 Csnk2a2 Topbp1 Rbbp8 Csnk2a1 Ssrp1 Brca1 Cdk5r1 Rad1 Csnk2b Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Ccna1 Taf12 Cdk5 Tbp Ccna2 Taf4b Taf7l-ps1 Tp53rkb Noc2l Tp53rka Taf8 Rps27a Taf7 Taf6 Taf5 Hipk1 Taf4 Taf2 Taf1 Blm Wrn Plk3 Dna2 Mre11 Uba52 Kat5 Nbn Hus1 Atrip Aurka Aurkb Chek1 Chek2 Rad9a Rpa1 Rad9b Rpa2 Bard1 Tpx2 Top3a Ubb Rpa3 Ubc Tp53 Rad17 Rfc5 Prkaa1 Mapk14 Rfc3 Prkaa2 Rfc4 Rfc2 Cdk2 Atm Atr Nuak1 Exo1 Prkag3 Prkag1 Rmi2 Prkag2 Mdm4 Rmi1 Brip1 Mapk11 Stk11 Mapkapk5 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 96%10224761 Phospholipase C-mediated cascade; FGFR3 Fgf16 Fgf17 Fgf18 Plcg1 Fgf2 Fgf1 Fgf20 Fgf4 Fgf23 Fgf5 Fgfr3 Fgf8 Fgf9 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 96%10222615 Metabolism of serotonin Maoa Aldh2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-RNO-597592.1 Post-translational protein modification Qtgal Adamts1 Adamts3 Adamts2 Adamts9 Adamts8 Adamts7 Adamts6 Pofut2 Thsd1 Thbs2 Pofut3 Pofut4 Thsd4 Cfp Spon2 Icmt Spon1 Sspo B3glct B3gnt9 B3gnt8 Fn1 B3gnt6 B3gnt5 Galnt1 Galnt2 Rce1 Galnt5 ENSRNOG00000067432 Galnt7 Fut8 Fuca1 Galnt6 Man2a1 Galnt10 Man2a2 Galnt17 Mgat2 Galnt18 Galnt15 Galnt16 Galnt13 Galnt14 Galnt11 Galnt12 Gcnt7 Gcnt4 Gcnt3 Chst4 Sema5a Sema5b Gcnt1 C1galt1 C1galt1c1 Galntl6 Mmrn2 Galntl5 Adamts13 Adamts14 Adamts15 Adamts16 Adamts17 Adamts18 Tgfa Adamts19 Fgf23 Adamts10 Sbspon Areg Kbtbd7 A4gnt Adamts12 Thsd7a Nop58 Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Galnt9 Commd9 Adamts20 Thsd7b Ceacam6 Cgm4 Commd3 Rab44 Rab37 Il6 Psgb1 Rab3d Fga Fgg Fcgr3a Psg29 Tf Cdc25a Hspa8 Rpa1 Mgat5 Mgat1 Slc35c1 Mgat3 Manea Man1c1 Man1a2 Man1a1 Mgat4c Mgat4b Rraga Rps6 Mvd Lrr1 Fbxl21 Wsb1 Ccnf Lypd6b Rtn4rl2 Gpld1 Cdc34 Lypd8 Tecta Lypd5 Lypd4 Lypd3 Negr1 Tex101 Lypd2 Lypd1 Alpl Opcml Tectb Dpm1 Dpm3 Otoa Izumo1r Ube2g2 Ly6g6d Ube2g1 Cd52 Prss21 Nrn1 Ntm Gp2 Kbtbd8 Xpnpep2 Fbxw4 Thy1 Fbxw5 Art4 Fbxw7 Art3 Gan Fbxw8 Atrnl1 Fbxw9 Lsamp Reck Sprn Plet1 Fbxw2 Psca Klhl5 Spaca4 Cntn4 Mdga1 Blm Klhl3 Cntn3 Mdga2 Klhl2 Cntn5 Spsb2 Ly6e Ly6h Prnd Spsb1 Ly6d Prss41 Spsb4 Pias4 Ube2i Eloc Elob Kctd7 Kctd6 Ube2w Ube2m Ube2k Ube2v2 Pdia3 Ube2b Bard1 Ube2f Ube2a Fbxo10 Prkdc Fbxo11 Fbxo15 Fbxo17 Clspn Lmo7 Lrrc41 Klhl13 B4galnt2 Klhl11 Ube2z Xrcc4 Fbxo21 Bap1 Fbxo22 Tp53bp1 Fbxo27 Brcc3 Uba6 Fbxw17 Herc2 Rnf168 Sumo1 Klhl25 Ube2e3 ABRAXAS1 Sumo3 Klhl21 Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Rad52 Fbxl5 Fbxl7 Zbtb16 Uba1 Babam1 Babam2 Cul2 Cul5 Ubxn1 Cul7 Brca1 Fbxo41 Fbxo44 Uimc1 Riox2 Klhl41 Fbxo40 Btbd1 Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Mitf Asb18 Asb17 Ube2r2 Fbxo4 Jmjd6 Fbxo6 Fbxo7 Fbxo9 Vhl Dync1h1 Fbxl15 Fbxl16 Fbxl19 Cdca8 Incenp Dync1i2 Dync1i1 Asb9 Asb7 Dhdds Asb6 Nudt14 Asb5 Alg5 Dolpp1 Asb4 Fuom Gmds Dolk Asb1 Fcsk Dhrsx Nus1 Fpgt Gfus Rangap1 Dync1li2 Dync1li1 Dynll1 Dynll2 Cop1 Mdm4 Birc5 Ogfod1 Riox1 Kdm8 Rccd1 Jmjd4 Drg1 Zc3h15 Jmjd7 Men1 Ube2t Otulin Tnks2 Axin1 Axin2 Dhps Eif5a Fn3k Fn3krp Eif5a2 Dohh Notum Alg9 Alg8 Cdc73 Alg6 Rnf146 Alg3 Alg2 Alg13 Alg14 Ctbp1 Alg12 Tnks Mpdu1 Dpagt1 Usp34 Smurf2 Leo1 Apc Amfr Engase Ngly1 Nlrp3 Rig1 Ikbke Cyld B3gnt7 B3gnt2 B4galt4 B4galt5 B4galt6 B4gat1 B4galt2 B4galt3 Ktn1 Psmg1 Psmg4 Psmg3 Psma4 Psmd10 Ccna1 Pomp Psma3 Psmd5 Psmd4 Ccna2 Ube2s Psma6 Psma5 Nrip1 Psma2 Psma1 Rps27a Psmd12 Dtl Psmd11 Ube2c Psmd14 Psmd13 Mta1 Skp2 Nr1h3 Skp1 Nr1h2 Cdc20 Psmb5 Psmb4 Psmb7 Rxra Psmb6 Dnajc3 Psmb1 Psmb3 Pgr Psmb2 Uba52 Nub1 Neurl2 Ube2d1 Commd8 Fem1b Fem1a Btrc Tulp4 Psma7 Fem1c Dcaf8 Dcaf4 Aurkb Dcaf5 Psmc5 Dcaf6 Psmc2 Dcaf7 Ccdc22 Psmc1 Psmc4 Obsl1 Psmc3 Dda1 Ccdc8 Commd4 Commd5 Commd6 Commd7 Commd2 Spsb3 Ubb Ankrd9 Rara Socs2 Ubc Commd10 Socs6 Ube2e1 Psmb6l1 Ubd Wdtc1 Npm1 Psmd7 Dcun1d5 Dcun1d4 Psmd6 Dcun1d3 Psmd8 Cish Dcun1d2 Psmd2 Dcun1d1 Cul9 Psmd1 Dcaf17 Adrm1 Dcaf10 Cul1 Dcaf11 Cdk1 Epas1 Hif3a Yy1 Dlat Nr5a2 Ins1 Lman1 Scfd1 Actr1a Lman2 Ins2 Ggcx Sec22a Bglap Dctn1 Tfg Dctn2 Cog1 Cog2 Dctn4 Cog3 Cog4 Arfgap3 Preb Rab2b Arfgap2 Rab34 Cog5 Rab20 Arfgap1 Igfbp3 Cog6 Ptp4a2 Rab23 Cog7 Rab26 Cog8 Rab25 Calm3 Napa Rab29 Nsf Rab40b Napb Rab15 Ank1 Rab17 Napg Rab19 Sec23a Rab3c Tmem115 Rab3b Kdelr2 Mettl22 Kdelr3 Sec23ip Etfbkmt Sec16b Kin Sec16a Mettl21a Eef2kmt Lman2l Copa Eef1akmt2 Bet1l Eef1akmt1 Cnih1 Gorasp1 Cnih3 Cnih2 Kdelr1 Arf4 Ctsc Arf3 Arf1 Ppp6r3 Mia2 Mia3 Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Col7a1 Ppp6c Muc15 Sec31b Muc13 Sec31a Muc19 F8 Umod Muc5b Muc4 Asgr2 Stx17 Gosr1 Muc6 Asgr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 Dlst Ckap4 Tp53 Skic8 Polb Parp1 H2ac4 Actl6a Gata3 Ring1 ENSRNOG00000066901 Phc2 Phc1 Cbx4 Hsp90b1 Ttll6 Socs5 Ttll7 Cbx2 Ttll4 Esr1 Phc3 Ttll5 Ttll10 Ttll2 Chst10 Ttll3 Fkrp Ttll11 Slc35a4 Rxylt1 Ttll12 Crppa Ttll8 Dag1 Ttll13 H2ac18 Ttll9 Large1 Large2 Sin3a Fktn Pomgnt1 Bmi1 Actg1 Hist1h2bq Hdac1 Wdr5 Ep300 Rnf2 ENSRNOG00000068602 Rabggta Kat2b Rabggtb Rbbp5 H2bc4 Hist1h4m H2bc1 Pml Hist1h2ai St8sia6 Etf1 St8sia4 St8sia5 Npl Neu2 Neu3 Neu4 Neu1 Cmas St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 St3gal6 St6galnac2 St3gal4 St3gal5 St3gal2 St3gal3 Slc35a1 St3gal1 Nanp St6gal1 Glb1 St6gal2 Nans St8sia2 St8sia3 St8sia1 Ctsa Gne Rbx1 Socs3 Vcp Hnrnpc Hnrnpk Cops5 Cul3 B3gnt3 Suz12 Rbbp7 Ube2d3 Ube2d2 Spta1 Sptb Sptbn1 Sptbn2 Ide Sptan1 Sptbn5 Sptbn4 Pex2 App Usp9x Nagk Gnpnat1 Traf6 Amdhd2 Pex5 Ikbkg Uap1 Gfpt1 Gfpt2 Map3k7 Pgm3 Ube2n Renbp Nfkb2 Traf2 Fbxw11 Rela Pex14 Tnip2 Pex13 Nod2 Pex12 Nod1 Pex10 Ripk2 Kat2a Hdac2 Hdac4 Nfkbia Usp14 Usp18 Tab1 Cetn2 Furin Alpi Nr1h4 Ltbp1 Bmp4 Fbn1 C4b Rab36 C4 Cops3 Cops6 Cops8 Rab11b Rab11a Rab31 Rab35 Rab38 Rab1b Trappc2l Gcsh Rab5a Lipt1 Rab4a Lipt2 Nfu1 Trappc10 Ndufab1 Fdx1 Rab33b Dbt Rab33a Lias Cops7a Cops7b Rab3a Tnc Dmp1 Chm Rab7a Rab7b Vcan Rab27a Rab39a Rab27b Akp3 Trappc6b Trappc6a Alpp Trappc9 Alpg Trappc5 Trappc4 Trappc3 F7 F9 Trappc2 Trappc1 Gas6 Rab6b Rab6a Ceacam1 Rab5c Ahsg Rab5b Spp2 Galnt3 Rab43 F10 Rab21 Chml Rab9a Rab9b Rab1A Ttgn1 Rab10 Rab13 Rab12 Rab14 Rab18 Rab8b Rab8a Qsox1 Serpina10 Rhoa Dph5 Dph6 Eef2 H2ac25 Gria1 Prmt3 Rps2 Serpind1 Calr Arsa Arrb2 Arrb1 Tgfbr1 Pros1 Sts Serpinc1 Arsl Arsk Cd109 Arsj Arsi Arsg Sumf1 Thbs1 Arsb Sumf2 Cdh2 Pcna Prkcsh Rab4b Cand1 Ctsz Pomt1 Pomt2 Scg3 Psme2 Psme1 Psmb9 Birc2 Proc Psmb10 Psmb8 Proz Aplp2 Mmrn1 Megf11 Canx Chgb Pdia6 Ccn1 Amelx Pigs Lgals1 Pigu Csf1 Pigt Gpaa1 Scg2 Pigk Apoa5 Meltf Plaur Pgap1 Mxra8 Fam20a LOC120093819 Fam20c Fuca2 Stc2 Wfs1 Apol7al1 Hrc Pcsk9 Ambn Mepe Cp Apol2 Enam Bmp15 Bpifb2 Apol7bl1 Ano8 Hcfc1 Igfbp7 Mfge8 Matn3 Rcn1 Vgf Vwa1 Fstl1 Fstl3 Chrdl1 Prss23 Tada3 Tmem132a Afp Pnpla2 Mbtps1 Nup93 Mcrs1 Igfbp5 Nup50 Igfbp4 Golm1 Igfbp1 Amtn Ogt Nup35 Mgat4a Nucb1 Nup54 Nup98 Sparcl1 Msln Cst3 Itih2 Nup58 Apol9a Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Ctr9 Nup160 Paf1 Rae1 Ndc1 Nup85 Nup42 Traf3 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 Tpst1 Nup133 Tpst2 Nup210 Nup155 Nup153 Srd5a3 Pign Pigq Alb Pigp Pigw Pigv Pigx Pigc Mrtfa Pigb Dpm2 Piga Pigm Pigl Pigg Pigf Pigh Gmppa Pmm2 Apoa1 Mpi Prkn Pmm1 Apoa2 Sar1b Ripk1 Gps1 Apoe P4hb Nploc4 Apob Ube2l3 Sdc2 Gpihbp1 Gpc3 Cops4 Cops2 Mgat5b B3galnt2 Pomk Pomgnt2 Rnf20 Adam10 Senp1 C3 Adamts5 Adamts4 Spp1 Uba2 Rwdd2b Sae1 Timp1 Eef1a1 F2 Penk Bst1 Vnn1 Rps23 Stambpl1 Nfrkb Myc Foxk2 Foxk1 Vdac2 Yod1 Vdac3 Vdac1 Tfpt Becn1 Tomm70 Otud7a Actr5 Otud7b Actr8 Josd2 Josd1 Rnf123 Rnf128 Stam Snx3 Ar Hif1a Zranb1 Cftr Cd55 Siah2 Keap1 Ino80 Wdr48 Ddb2 Ufd1 Foxo4 Uchl3 Abraxas2 Uchl5 Folr2 Ifih1 Fkbp8 Ino80e Ino80d Rnf181 Ino80c Shprh Ino80b Rad18 Il33 Wdr20 Rnf152 Rnf40 Mbd5 Mbd6 Adrb2 Rnf144a Hltf Uchl1 Wac Nedd8 Atxn3 Atxn7 Suds3 Usp2 Mul1 Usp3 Usp4 Kdm1b Usp5 Usp7 Usp8 Hgs Ruvbl1 Stambp Rad23a Rad23b Tomm20 Tada2b Senp5 Senp5l1 Smad1 Sumo2 Smad2 Senp2 Smad3 Smad4 Smad7 Otub1 Usp44 Usp42 Usp48 Kng1 Usp47 Stam2 Usp30 Otub2 Vcpip1 Usp33 Usp37 Mysm1 Tnip3 Tnip1 Senp8 Otud3 Usp22 Usp21 Usp20 Usp26 Usp25 Usp24 Usp29 Usp28 Ccp110 Asxl1 Asxl2 Pten Usp12 Usp11 Usp10 Usp16 Usp15 Usp13 Usp19 Etfb Bcl10 Rab2a Nr1i2 Smc6 Smc5 Smc3 Pias3 Ddx17 Sp140 Pias1 Pias2 Nsmce4a Casp8ap2 Hic1 Eid3 Uhrf2 Nr3c2 Nr3c1 Nsmce1 Nsmce2 Xpc Zfp131 Sp3 Vdr Stag2 Stag1 Dnmt1 L3mbtl2 Daxx Safb Mageb10 Sp100 Ing2 Ppara Top2b Top2a Top1 Trim28 Trim27 Pcgf2 Thrb Thra Mbd1 Satb2 Satb1 Park7 Smc1a Nr5a1 Nfe2l2 Taf9b Tfap2c Taf10 Tdg Rpl8 Camkmt Ubxn7 Rpl27a Ddb1 Cul4a Dcaf13 Cul4b Mat2b SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-RNO-3232118.1 SUMOylation of transcription factors Sumo3 Pias4 Tfap2c Sp3 Ube2i Sumo2 Tp53bp1 Mitf Pias3 Mta1 Pias1 Pias2 Hic1 Sumo1 INOSITOL TRANSPORTERS%REACTOME%R-RNO-429593.1 Inositol transporters Slc5a11 Slc5a3 Slc2a13 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME%R-RNO-983170.1 Antigen Presentation: Folding, assembly and peptide loading of class I MHC Tapbp RT1-M1-5 Calr Rt1-ec3 Sec24d Sec24c Sec24b Sec24a Erap1 Hspa5 RT1-M6-2 AABR07044308.1 Pdia3 B2m Sec23a Tap2 Tap1 RT1-M10-ps1 RT1-M10-ps5 Canx RT1-N3 Sec13 RT1-M5 Sar1b RT1-M2 Sec31a RT1-M1-2 SIGNALING BY NOTCH3%REACTOME%R-RNO-9012852.1 Signaling by NOTCH3 Aph1b Ybx1 Egfr Jag1 Uba52 Jag2 Notch3 Dll1 Dll4 Rps27a Egf Adam10 Wwp2 Psenen Psen1 Psen2 Ubb Ncstn Ubc Aph1a COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%10224947 COPI-dependent Golgi-to-ER retrograde traffic Rab1A Arfgap3 Arfgap2 Arfgap1 Racgap1 Bnip1 Napa Nsf Kif18b Napb Kif19 Kif26b Napg Kifc1 Kifc2 Kif3a Kif26a Kdelr2 Kdelr3 Kif11 Kif12 Copa Kif15 Nbas Kif5a Kif5b Kif21a Kif1c Kdelr1 Arf4 Kif21b Arf3 Kif13b Arf1 Kif1a Kif1b Kif6 Copb2 Tmed10 Tmed9 Kif9 Copb1 Zw10 Cope Kif22 Rab1b Kif23 Kif28 Rint1 Kif27 Kif16b Kif18a Kif20a Klc1 Copz2 Kif20b Kifap3 Copz1 Arf5 Klc4 Klc3 Klc2 Kif3b Kif3c Gbf1 Tmed2 Tmed3 Copg1 Copg2 Tmed7 Arcn1 Stx18 Cenpe Kif2a Use1 Kif2b Kif2c Kif4b Kif4a PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 96%10225111 Processing of SMDT1 Phb1 Pheta2 Micu2 Micu3 Pmpcb Micu1 Pmpca Maip1 Afg3l2 Mcub Yme1l1 Mcu Parl Stoml2 Spg7 Phb2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME DATABASE ID RELEASE 96%10224403 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Cyp1a1 Cyp4f3 Cyp4a12 Cyp1a2 Cyp4f40 Cyp1b1 Cyp2u1 Cyp4f4 Cyp2c66 Cyp4f1 Cyp2c11 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-RNO-5693571.1 Nonhomologous End-Joining (NHEJ) Rif1 Polm Rnf8 Paxip1 Dclre1c Pias4 Ube2n Mre11 Nsd2 Kat5 Rad50 Nbn Lig4 Babam1 Babam2 Ube2v2 Brca1 Bard1 Hist1h2bq Uimc1 Prkdc Poll Nhej1 Xrcc6 Tdp2 Xrcc5 Tdp1 Xrcc4 Hist3h2ba Atm Tp53bp1 Brcc3 ENSRNOG00000066901 Herc2 H2bc4 Rnf168 Hist1h4m H2bc1 ABRAXAS1 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-RNO-73930.1 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Polb Apex1 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%10222413 Nervous system development Erbb2 Gsk3b Frs2 Prkcq Ranbp9 Tln1 Rasa1 Fgfr1 Creb1 Ret Spta1 Col4a1 Ptpra Col4a2 Ncam1 Sptb Sptbn1 Sptbn2 Ptk2 Sema5a Mapk3 Sptan1 Sptbn5 Artn Ptprc Rps6ka5 Gfra1 Nras Sptbn4 Grb2 Gfra2 Gfra4 Fyn Kras Sos1 Hras Sdc2 Mapk7 Arpc3 Arpc2 Map2k2 Sema4d Plxnb1 Map2k1 Arpc5 Arpc4 Dnm2 Nrp1 Efna1 Egfr Efna2 Epha1 Shc3 Epha3 Hsp90ab1 Epha4 Pspn Epha5 Epha6 Epha7 Epha10 Efna4 Dcc Gdnf Efna5 Dpysl2 Arpc1b Kif4b Actr2 Ap2s1 Arpc1a Kif4a Actr3 Rdx Msn L1cam Dnm3 Ap2a2 Ap2a1 Ap2b1 Nrtn Arhgef28 Numb Sh3gl2 Ezr Itgav Rhoc Cd72 Plxnb3 Sema6d Crmp1 Plxna4 Myo9b Plxna3 Shank3 Itga2b Plxna2 Rras Tyrobp Met Plcg1 Sema4a Dpysl3 Dpysl4 Dpysl5 Plxnc1 Arhgap35 Sema3a Sema7a Fes Trem2 Sema3e Itgb1 Plxna1 Grb10 Itgb3 Sdcbp Efnb1 Arhgef7 Rock2 Efnb2 Rock1 Efnb3 Plxnd1 Ephb1 Dscaml1 Ephb2 Ntn4 Ephb3 Dscam Ephb4 Ephb6 Unc5a Nck2 Rac1 Pak3 Rnd1 Git1 Hsp90aa1 Sh3kbp1 Limk1 Dok1 Nck1 Actb Itga9 Mmp2 Mmp9 Lypla2 Gap43 Mapk1 Grb7 Prkaca Prkacb Pdlim7 Dok4 Dok5 Prkca Dok6 Cdk5r1 Ank1 Pak1 Pak2 Cdk5 Lyn Nfasc Yes1 Src Rlc-a Rhoa Ngef Grin1 Grin2b Adgrg6 Epha2 Reln Dab1 Rhob Rap1gap Dok2 Csnk2a2 Csnk2a1 Actg1 Csnk2b Pik3ca Tiam1 Shc1 Gab2 Farp2 Pip5k1c Pik3r1 Arhgef11 Pik3cb Arhgef12 Vav3 Pik3r2 Pik3r3 Vav2 Pik3cd Itsn1 Ptpn11 Psenen Psen1 Psen2 Kalrn Ncstn Aph1a Gab1 Aph1b Irs2 St8sia4 Vldlr Trio St8sia2 Ap2m1 Clta Cltc Dnm1 Cdc42 CO-INHIBITION BY CTLA4%REACTOME%R-RNO-389513.1 Co-inhibition by CTLA4 Ppp2r5b Ppp2r5a Ppp2cb Ppp2ca Ppp2r1b Ppp2r1a Akt3 Lyn Akt2 Yes1 Akt1 Src Ppp2r5e Cd86 Fyn Cd80 Ptpn11 Ppp2r5d Lck Ctla4 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-RNO-5693579.1 Homologous DNA Pairing and Strand Exchange Mre11 Kat5 Rad51 Rad50 Nbn Rad51c Rad51b Chek1 Rbbp8 Brca2 Brca1 Rad51ap1 Bard1 Top3a Palb2 Xrcc3 Xrcc2 Atm Exo1 Rmi2 Rmi1 Blm Brip1 Wrn Dna2 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-RNO-193692.1 Regulated proteolysis of p75NTR Aph1b Nfkb1 Adam17 Psenen Ngfr Psen1 Psen2 Ncstn Aph1a Rela Traf6 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 96%10223929 Activation of Ca-permeable Kainate Receptor Grik5 Grik2 Grik1 Grik4 Calm3 Grik3 Ncald Dlg1 Dlg3 Dlg4 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME%R-RNO-5624138.1 Trafficking of myristoylated proteins to the cilium Unc119b Rp2 Nphp3 Arl3 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 96%10224173 Ca activated K+ channels Kcnmb1 Kcnmb2 Kcnmb3 Kcnmb4 Kcnn4 Kcnn3 Kcnn2 Kcnma1 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 96%10224539 WNT ligand biogenesis and trafficking Wnt11 Wnt4 Wnt2b Wnt16 Wnt1 Wnt5a Vps26a Vps35 Vps29 Wnt10a Wnt10b Wls Wnt9a Wnt9b Wnt7a Tmed5 Snx3 Wnt5b Wnt8b Wnt6 Wnt8a Wnt2 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 96%10222293 Synthesis of PA Agpat3 Ddhd2 Agpat4 Agpat1 Agpat2 Alpi Lclat1 Pla2g2d Pla2g2f Pla2g2a Gnpat Pla2g1b Pla2g4d Pla2r1 Pla2g12a Lpcat4 Pla2g10 Pld2 Pla2g5 Lpcat1 Pld1 Gpd1l Miga2 Gpat2 Miga1 Gpd1 Gpam Gpd2 Pld6 Pla2g4a Liph Lipi Pla2g4b Acp6 Gpat4 Gpat3 PRE-NOTCH PROCESSING IN GOLGI%REACTOME DATABASE ID RELEASE 96%10224349 Pre-NOTCH Processing in Golgi Tmed2 Notch4 Notch3 HSF1 ACTIVATION%REACTOME%R-RNO-3371511.1 HSF1 activation Hsf1 Ywhae Eef1a1 Hsp90ab1 Ptges3 Vcp Hsp90aa1 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-RNO-1660499.1 Synthesis of PIPs at the plasma membrane Rab14 Ocrl Inpp5j Synj1 Pik3c2g Inpp5d Pik3ca Mtmr1 Pip5k1c Arf1 Pik3r1 Pik3cb Pik3r2 Synj2 Pik3r3 Inppl1 Pik3cd Ptpn13 Pi4k2b Inpp4a Inpp4b Pik3c2a Plekha8 Mtm1 Pik3r5 Pik3cg Pi4k2a Pip4k2b Pip4k2c Pip4k2a Rab5a Pten Rab4a Pip5k1b Pip5k1a Mtmr14 Plekha6 Plekha5 Plekha4 Plekha3 Plekha2 Plekha1 Mtmr3 Rufy1 Inpp5k Pik3c2b Bmx Mtmr6 Mtmr9 Pik3r6 OLEOYL-PHE METABOLISM%REACTOME%R-RNO-9673163.1 Oleoyl-phe metabolism Pm20d1 G0 AND EARLY G1%REACTOME DATABASE ID RELEASE 96%10224125 G0 and Early G1 E2f5 Dyrk1a Tfdp2 Tfdp1 Ccna1 Lin52 Ccna2 Rbbp4 Rbl2 Lin54 Cdk2 Rbl1 Ccne1 Ccne2 Lin9 Lin37 Hdac1 E2f4 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%10222775 Insulin effects increased synthesis of Xylulose-5-Phosphate Taldo1 Tkt TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10222799 TRIF (TICAM1)-mediated TLR4 signaling Ppp2cb Ppp2ca Ube2d3 Ppp2r5d Ube2d2 Creb1 Ppp2r1b Ppp2r1a Mapk3 Ripk3 Rps6ka5 Ripk1 Fadd Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Mapk7 Nkiras2 Mapk8 Traf6 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Nfkb2 Nfkb1 Traf2 Fbxw11 Fos Vrk3 Alpk1 Rela Rps6ka3 Rps6ka1 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Tbk1 Jun Irf3 Mapkapk2 Irak2 Irak1 Ager Nfkbia Ikbke Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Birc2 Optn Rps27a Ptpn11 Skp1 Uba52 Ube2d1 Btrc Ubb Ubc Cul1 Mapk1 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%10222391 GRB2 events in EGFR signaling Grb2 Egfr Egf Kras Sos1 Hras Ereg Tgfa Areg Hbegf Btc Nras SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193368.1 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Hsd3b7 Ncoa2 Akr1d1 Amacr Baat Cyp8b1 Akr1c18 Cyp7b1 Akr1c12l1 Akr1c19 Nr1h4 Akr1c21 Scp2 Cyp27a1 Slc27a5 Cyp7a1 Acox2 Abcb11 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Hsd17b4 Akr1c9 Slc27a2 Acot8 Rxra TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-RNO-174430.1 Telomere C-strand synthesis initiation Acd Terf1 Terf2ip Tinf2 Pot1 Pola2 Pola1 Prim2 Prim1 Ctc1 Stn1 Ten1 Terf2 INNATE IMMUNE SYSTEM%REACTOME%R-RNO-168249.1 Innate Immune System Prkcq Cfp Fuca1 Rap1a Rap1b Bcl2l1 Mmtag2 Nbeal2 Prdx4 Plac8 Pgrmc1 Commd9 Golga7 Retn Lgals3 Ptprn2 Bin2 Cd36 Pa2g4 S100a11 S100a9 Dynlt1 Gmfg Syngr1 Clec4a3 Clec4a2 Glipr1 Man2b1 Tmc6 Clec4b2 Grn Ceacam6 Enpp4 Fcer1a Cgm4 Ypel5 Txk Ppp3ca Nfam1 Clec6a-ps1 Ppp3cb Itk Aga Commd3 Nfatc1 Pigr Nfatc3 Pygb Nfatc2 Crispld2 Ppp3r1 Grap2 Ormdl3 Lamtor3 Ms4a2 Dnajc13 Lamtor2 Lilrc2 Tec Rab44 Adgrg3 Vcl Ear1l1 Chrnb4 Epx Kcmf1 Tom1 Serpinb1a Rab37 Serpinb12 Ist1 Serpinb10 Psgb1 Pkp1 Dsc1 Bri3 Gpr84 Ptprb Ghdc Lamp1 Arl8a Rab3d Nit2 Chi3l1 Lat Mospd2 Acp3 Slc2a5 Alad Crisp2 Olfm4 Atad3a Fgl2 Dnase1l1 Hgsnat Mnda Fgb Fga Frmpd3 Rnase17 Fgg Agpat2 Fcgr3a Mcemp1 Scamp1 Tmem179b Cant1 Unc13d Cpne1 Cpne3 Tmem30a Rnase2 Rnase3 Pld4 Vat1 Mapk12 Tspan14 Prg3 Anpep Atp6v0b Prg2 Bst2 Atp6v0a4 Rap2b Rap2c Atp6v1g3 Manba Cap1 Atp6v0e2 Atp6v1c2 Mlec Cd53 Atp6v0a1 Atp6v1c1 Stk11ip Svip Atp6v0c ENSRNOG00000064486 Qpct ENSRNOG00000064129 Tlr9 Irag2 Cstb Gca Atp6v1e2 Erp44 Creg1 Atp6v1e1 Tcirg1 Cd68 Atp6v1a Dok3 Atp6v1b2 Hebp2 Cd93 Atp6v0d2 ENSRNOG00000067708 Atp6v0d1 Atp6v1b1 Cotl1 Dpp7 Atp6v0e1 Tarm1 Atp6v1g2 Degs1 Atp6v1g1 Atp6v1f Ggh Atp6v1d Cnn2 Nme2 Psg29 Dnajc5 Ddx3x Cracr2a Clec4a Clec4d Cpped1 Mvp Ms4a3 Pdap1 Kcnab2 Oscar Tmem63a Cmtm6 Tnfaip6 Vps35l Ostf1 Ap1m1 Ptx3 Vamp8 Slc44a2 Txndc5 Hspa8 Cab39 Lamtor1 Cd180 Ly86 Ptpn4 Tasl Eea1 Tlr10 Irf5 RT1-M6-2 Mgst1 Cdc34 B2m Gstp1 Atg7 RT1-M10-ps1 RT1-M10-ps5 Snap23 Pak1 RT1-N3 Pak2 Apeh RT1-M1-2 RT1-M1-5 Mre11 Rt1-ec3 Huwe1 Ncf1 Ncf2 Ncf4 Ube2m Xrcc6 Xrcc5 RT1-M5 Ubr4 RT1-M2 Unc93b1 Lgmn Tlr8 Cnpy3 Padi2 Cyba Cybb Uba3 Myo5a Trim21 Dync1h1 Trim32 AABR07044308.1 Lpcat1 Clec7a Card9 Gpi Arg1 Dync1li1 Aoc1 Dynll1 Pgam1 Aldoc Aldoa Pfkl Pdpk1 ENSRNOG00000070986 Lat2 Ctnnb1 Pkml1 Hk3 Hspa1b Hspa1a Clec4e Ptprc S100a1 Gsdme Tlr1 Gsdmd Tlr7 Tlr6 Lbp S100a8 Tlr2 Ctsb Arhgap45 Ctss Dnm2 Jup Stom Impdh2 Pycard Panx1 Txnip Arhgap9 Impdh1 Sugt1 Nlrp3 Txn Pld1 Mefv Pstpip1 Nlrp1a Hsp90ab1 P2rx7 Stk10 Tbk1 Irf3 Mavs Faf2 Rig1 Tax1bp1 Ikbke Cyld Diaph1 Gns C1qbp Galns Hexb H2az1 Krt1 Prcp Stbd1 Dock2 Myo9b Plcg1 Pla2g2a Sdcbp Rock1 Dhx36 Rac1 Pak3 Psma4 Psma3 Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Dnajc3 Psmb1 Psmb3 Psmb2 Myh9 Uba52 Myo10 Ube2d1 Btrc Psma7 Nck1 Ilf2 Psmc5 Actb Psmc2 Psmc1 Srp14 Psmc4 Psmc3 Dhx9 Ubb Ubc Psmb6l1 Psmd7 Casp1 Psmd6 Psmd8 Mmp9 Psmd2 Psmd1 Adrm1 Cul1 Nos3 Mapk1 Fabp5 Ppp2cb Ppp2ca Prkaca Prkacb Prkcd Gusb Calm3 Ppp2r5d Tollip Ppp2r1b Il1b Ppp2r1a Nfasc Ctsc Copb1 Serpina1 Actr10 Hbb Ctsh Cd59 Ckap4 Idh1 H2ab2 H2ac4 Abl1 ENSRNOG00000066901 Stat6 Hsp90b1 Crebbp H2ac18 Ctsk Ctsl Actg1 Hist1h2bq Csnk2b H3-3b Hist3h2ba Ep300 ENSRNOG00000068602 Itch Vav3 Vav1 Vav2 Ptpn11 H2bc18 Psen1 H2bc4 Hist1h4m Ncstn H2bc1 Hist1h2ai Neu1 Myo1c Casp2 Myd88 Glb1 Ctsa Dnm1 Vcp Cdc42 Slco4c1 Ddost Magt1 Ppie Ube2d3 Ube2d2 Acaa1b Creb1 Slc27a2 Ptk2 Mapk3 Sptan1 Ddx41 Rps6ka5 Nras Sting1 Grb2 Fyn Kras Sos1 Mapk13 Hras Nkiras1 App Mapk9 Atf2 Tnfrsf1b Ikbkb Atf1 Slc15a4 Mapk7 Nkiras2 Iqgap2 Mapk8 Traf6 Peli1 Ikbkg Cat Map3k8 Map3k7 Ube2n Relb Lrrc14 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Vrk3 Vapa Alpk1 Rela Rps6ka3 Map3k1 Peli2 Nos2 Rps6ka1 Peli3 Map3k14 Tifa Ptges2 Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Dusp3 Kpnb1 Hmgb1-ps34 Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Armc8 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Usp14 Tab3 Cep290 Tab2 Dnm3 Usp18 Ap2a2 Tab1 Nlrc5 Chuk Mapk10 Mapk11 Tubb5 Itgav Chit1 Tubb4b Cdk13 Fcn2 Fcn1 Cr2 Serping1 Cr1l Clu Mbl2 Cd81 Snap29 Masp1 Masp2 Rbsn C4b C1qb Crp C1qa Cfh Cfi C2 Elane C4 Hp Colec10 C6 C9 Cd46 Cfhr1 C1s C1r Optn Cpn1 Cpn2 Cd19 Rab31 C1qc Fth1-ps5 Pik3c3 Pafah1b2 Pik3r4 Fth1 Rab3a Ftl1 Plcg2 Itgax Gdi2 Pla2g6 Rab7a Prkce Cfd A1bg Rab27a Hrg Olr1 Tbc1d10c Trappc1 Rab6a Ceacam1 Rab5c Ahsg Crk Rab5b Serpina3n F12 Serpinb6a Rab9b Rab10 Igf2r Rab14 Rab18 Nlrp4 Dtx4 Anxa2 Qsox1 Gsn Sh3glb2 Plpp4 Lamp2 Plpp5 Pld3 Pnp Cd177 Ampd3 Aprt Lyn Yes1 Src Rhoa Lrrc7 Itgal Eef2 Itgb2 Lcp2 Lpo Arsa Mpo Cd3g P2rx1 Asah1 Gm2a Aamp Trem1 Cd4 Mif Lck Gla Arsb Raf1 Orm1 Rhog Rac2 Ano6 Rab4b Atp6ap2 Cd47 Ctsd Mme Ctsg Cd63 Cand1 Ctsz Prtn3 Cpb2 Ppia Aim2 Fcer1g Birc2 Sell Sirpa Plau Pecam1 Nos1 Pik3ca Shc1 Npc2 Ptpn6 Gab2 Pik3r1 Pik3cb Plaur Pik3r2 Fuca2 Trpm2 Bpifb2 Alox5 Lta4h Cst3 Atp11b Atp11a Atp8b4 Traf3 Tank Ly96 Ticam2 Sarm1 Irf7 Ticam1 Cd14 Tlr4 Hmox2 Hpse Nckap1l Wipf3 Wipf1 Ripk3 Ripk1 Capza1 Capza2 Apob Fadd Abi2 Abi1 Ttr Arpc3 Arpc2 Arpc5 Arpc4 Dgat1 Brk1 Dsp Dsg1 Elmo1 C3ar1 Wasf3 Wasf2 Wasf1 Cd209a Arpc1b Actr2 Mmp25 Arpc1a Ppbp Actr3 Fpr1 Btk Adam10 Fpr2 C3 Nckap1 C5 Cyfip2 Cyfip1 Rhof Adam8 Mmp8 Try10 Prss2l1 Nckipsd Tyrobp Klkb1 Try5 Trem2 Cd44 LOC102554637 Pld2 Elmo2 Capn1 Timp2 Prss2 Acly Prss3 Prss1 Baiap2 Ccr6 A2m Eef1a1 Limk1 F2 Pdxk Bst1 Vnn1 Ptafr Naprt Slc2a3 Tomm70 Cyb5r3 Dera Pgm2 Cd55 Clec5a Siglec15 Siglec10 Klrd1 Klrc2 Klrk1 Klrc1 Cxcr1 Apaf1 Cxcr2 Folr2 Cda C5ar2 C5ar1 Atp7a Defb41 Defb42 Np4 Defb43 Defb44 Kng1 Defa24 Svs3b Ear1 Bpifb1 Bpifb6 Bpifb4 Defal1 Pglyrp1 Pglyrp2 Reg3a Reg3b Pglyrp3 Pglyrp4 Defa31 Stath Reg3g Bpi Defa Camp Chga Ltf Lyz1 Ndufc2 Bpifa1 Bpifa2 Defb14 Defb17 Defb18 Art1 Defb21 Defb5 Rnase6 Defb24 Defb1 Slc11a1 Defb25 Eppin Aldh3b1 Defb28 Defa9 Defa8 Defb30 Defa6 Defa3 Itln1 Lcn2 Atox1 Malt1 Bcl10 Snap25 Psap Tirap Actr1b Siglec5 Siglec8 Adgre5 Cct2 Cxcl1 Lair1 Cct8 Gaa Agl Pygl Gyg1 Pgm1 ENSRNOG00000069193 AABR07065813.1 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Fcgr2 Syk Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 Fgr ENSRNOG00000065564 Frk Hck Prdx6 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 Casp9 AABR07065812.2 ENSRNOG00000063707 Fcgr1a ENSRNOG00000067679 ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 Icam2 ENSRNOG00000063713 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 Hvcn1 REGULATION OF INSULIN SECRETION%REACTOME DATABASE ID RELEASE 96%10223465 Regulation of insulin secretion Adcy5 Kcnb1 Adcy6 Kcns3 Kcnc2 Kcng2 Prkaca Prkacb Gnai2 Gnai1 Prkca Cacna1c Gna11 Cacna1d Gna14 Marcks Gng3 Gng5 Gng4 Gnaq Gng7 Cacnb3 Gng8 Cacna1e Gngt1 Cacnb2 Itpr3 Cacna1a Itpr2 Slc2a2 Itpr1 Cacna2d2 Ffar1 Gnb2 Abcc8 Gnb1 Kcnj11 Gnb4 Gnb3 Gnb5 Gng11 Rap1a Gnas Acsl3 Acsl4 Cd36 Adra2a Adra2c Rapgef4 Rapgef3 Slc2a1 Gcg Plcb3 Glp1r Plcb2 Plcb1 Gng10-ps1 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 96%10224057 N-glycan trimming and elongation in the cis-Golgi Man1a2 Man1a1 Mgat1 Manea Man1c1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-RNO-174437.1 Removal of the Flap Intermediate from the C-strand Acd Terf1 Fen1 Terf2ip Pold2 Pold1 Tinf2 Pot1 Pcna Pold4 Pold3 Rpa1 Rpa2 Wrn Rpa3 Terf2 Dna2 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 96%10223253 ERK MAPK targets Dusp7 Dusp6 Ppp2cb Ppp2ca Mapk14 Ppp2r1b Ppp2r1a Mapk3 Vrk3 Rps6ka5 Rps6ka3 Mapk1 Rps6ka1 Rps6ka2 Ppp2r5d Mapk11 Mapk7 Dusp3 Dusp4 MEIOTIC RECOMBINATION%REACTOME%R-RNO-912446.1 Meiotic recombination Fignl1 Rad51 Dmc1 Firrm VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 96%10225013 VLDL clearance Apobr Vldlr Apob Apoc1 Apoc4 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-RNO-4085377.1 SUMOylation of SUMOylation proteins Nup133 Sumo3 Nup210 Nup155 Pias4 Nup153 Ube2i Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Sumo1 Nup214 RESPONSE TO METAL IONS%REACTOME%R-RNO-5660526.1 Response to metal ions Mt2 Mt3 NEUREXINS AND NEUROLIGINS%REACTOME DATABASE ID RELEASE 96%10224893 Neurexins and neuroligins Shank1 Shank3 Cask Homer1 Homer2 Nrxn1 Nrxn2 Nrxn3 Epb41 Epb41l2 Epb41l3 Epb41l5 Lrrtm1 Lrrtm2 Lrrtm3 Lrrtm4 Dlgap1 Homer3 Dlgap4 Dlgap3 Dlgap2 Nlgn2 Nlgn1 Sh3glb2 Nlgn3 Grm1 Grm5 Epb41l1 Dlg2 Dlg3 Dlg4 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME%R-RNO-5693565.1 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Rnf8 Pias4 Ube2n Mre11 Ube2i Uba52 Nsd2 Kat5 Rad50 Nbn Eya2 Eya1 Eya4 Babam1 Eya3 Baz1b Babam2 Chek2 Ubxn1 Ube2v2 Brca1 Bard1 Hist1h2bq Uimc1 Ubb Ubc Tp53 Hist3h2ba Atm Bap1 Tp53bp1 Apbb1 Rps27a Kdm4b Kdm4a Abl1 Brcc3 ENSRNOG00000066901 Smarca5 Ppp5c Herc2 H2bc4 Rnf168 Hist1h4m Mapk8 Sumo1 H2bc1 ABRAXAS1 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 96%10223869 RHO GTPases activate PAKs Ppp1r12a Flna Pak1 Calm3 Rac1 Pak3 Pak2 Cdc42 Limk1 Ppp1cb Ppp1r12b Mylk DEADENYLATION OF MRNA%REACTOME%R-RNO-429947.1 Deadenylation of mRNA Eif4a2 Eif4a1 Pan2 Paip1 Pan3 Eif4e Pabpc1 Eif4a3 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-RNO-72695.1 Formation of the ternary complex, and subsequently, the 43S complex Rps14 Rps15 Rps16 Eif2s3 Rps17 Rps15a Rps18 Eif2s2 Rps19 Rps2 Eif2s1 Rps27 Rpsa Rps10 Rps11 Rps13 Rps4x-ps13 Rps3a Rps27l Rps9 Rps7 Uba52 Rps8 Rps5 Rps26-ps13 Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Rps3 Rps25 Rps4x Rps26 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Eif1ax Fau Rps6 POTASSIUM TRANSPORT CHANNELS%REACTOME DATABASE ID RELEASE 96%10224177 Potassium transport channels Kcnj16 Kcnj10 Kcnj1 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 96%10224201 TWIK-related spinal cord K+ channel (TRESK) Kcnk18 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-RNO-9758890.1 Transport of RCbl within the body Ldlrap1 Lrpl1 Tcn2 Abcc1 Lrp2 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223461 Peptide hormone biosynthesis Fshb Inha Pcsk1 Pomc Lhb Inhba Cga Inhbb Tshb Inhbc Inhbe SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-RNO-111367.1 SLBP independent Processing of Histone Pre-mRNAs Snrpg Ncbp2 Snrpb Ncbp1 Zfp473 Snrpepl2 Lsm10 Lsm11 Snrpf Snrpd3 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-RNO-9933937.1 Formation of the canonical BAF (cBAF) complex Smarcc1 Smarca2 Smarca4 Arid1a Arid1b Actl6a Smarcd1 Ss18 Smarce1 Dpf1 Dpf2 Dpf3 Actg1 Ss18l1 Bcl7a Smarcb1 Bcl7b Bcl7c NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%10223559 Nuclear Receptor transcription pathway Nr1d2 Nr1d1 Vdr Esr1 Nr2c1 Nr1h4 Ppara Nr1i3 Thrb Thra Nr5a1 Nr2f6 Nr0b2 Nr0b1 Nr2f1 Nr2e3 Nrbf2 Nrbf2l1 Med1 Nr1h3 Nr1h2 Rxrb Rxra Pparg Pgr Nek4 Rxrg Rorc Rorb Nr4a1 Esr2 Esrra Rara Esrrb Esrrg Ppard Nr6a1 Nr2c2 Ncor2 Hnf4a Nr1i2 Rarg Hnf4g Nr5a2 Nr4a3 Nr4a2 Ar Nr3c2 Nr3c1 DEFENSINS%REACTOME%R-RNO-1461973.1 Defensins Defa Try10 Tlr1 Prss2l1 Defb14 Defb17 Defb18 Art1 Defb21 Tlr2 Defb5 Defb24 Defb1 Defb25 Try5 Defb28 LOC102554637 Defa9 Cd4 Defa8 Defb30 Defa6 Defa3 Prss2 Prss3 Prss1 Defb41 Ccr6 Defb42 Np4 Defb43 Defb44 Defa24 Defal1 Defa31 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-RNO-5621481.1 C-type lectin receptors (CLRs) Pdpk1 Prkaca Prkacb Prkcd Cdc34 Calm3 Ube2d2 Clec4e Pak1 Il1b Pak2 Lyn Src Rps6ka5 Nras Fyn Kras Hras Ikbkb Traf6 Ikbkg Map3k7 Ube2n Relb Nfkb2 Nfkb1 Fbxw11 Rela Ube2m Map3k14 Ppp3ca Ppp3cb Clec6a-ps1 Nfatc1 Nfatc3 Pycard Malt1 Nfatc2 Bcl10 Ppp3r1 Raf1 Casp8 Cd209a Nfkbia Tab3 Tab2 Tab1 Chuk Fcer1g Crebbp Uba3 Pak3 Psma4 Psma3 Psma6 Ep300 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Clec4d Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Ube2d1 Syk Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Plcg2 Ubb Ubc Psmb6l1 Psmd7 Icam2 Clec7a Psmd6 Card9 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10223937 MAP3K8 (TPL2)-dependent MAPK1 3 activation Ikbkg Map3k8 Uba52 Nfkb1 Fbxw11 Cul1 Btrc Rps27a Tnip2 Chuk Ikbkb Ubb Skp1 Ubc ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME%R-RNO-9026527.1 Activated NTRK2 signals through PLCG1 Bdnf Ntrk2 Plcg1 Ntf4 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-RNO-1660517.1 Synthesis of PIPs at the late endosome membrane Fig4 Vac14 Mtmr7 Mtmr4 Pik3r4 Pikfyve Pik3c2a Pik3c3 Mtm1 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME DATABASE ID RELEASE 96%10222419 Global Genome Nucleotide Excision Repair (GG-NER) Chd1l Sumo3 Ino80 Xpc Ddb2 Cdk7 Ino80e Ino80d Ino80c Ercc1 Ino80b Ercc4 Usp45 Mnat1 Polk Actg1 Rnf111 Ruvbl1 Rad23a Rad23b Sumo2 Cops3 Cops6 Cops8 Rps27a Gps1 Ube2n Gtf2h2 Ube2i Uba52 Gtf2h1 Gtf2h3 Gtf2h5 Cops4 Ercc2 Ercc3 Cops2 Pole3 Pole2 Cops7a Pole4 Cops7b Ube2v2 Rpa1 Rpa2 Mcrs1 Ubb Rpa3 Ubc Pole Parp2 Parp1 Rfc5 Pold2 Nfrkb Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Rfc2 Ccnh Pold4 Tfpt Pold3 Actl6a Actr5 Yy1 Pias3 Actr8 Pias1 Cops5 Xpa Ddb1 Cul4a Sumo1 Cetn2 Cul4b SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 96%10224287 Sulfide oxidation to sulfate Usf1 Slc25a10 Sqor Ethe1 Suox FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-RNO-9933947.1 Formation of the non-canonical BAF (ncBAF) complex Smarcc1 Smarca2 Smarca4 Actl6a Smarcd1 Ss18 Smarcd3 Bicral Smarcd2 Bicra Brd9 Actg1 Ss18l1 Bcl7a Bcl7b Bcl7c REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%10225549 Regulation of GBP-mediated host defense Casp1 Pim1 Sfn Gbp1 Gbp3 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-RNO-202733.1 Cell surface interactions at the vascular wall Jam2 Grb7 Grb14 Jaml Fn1 Itga3 Itga4 Esam Cd177 Lyn Yes1 Src Spn Nras Grb2 Itgal Fyn Kras Apob Sos1 Hras Itgb2 Cd244 Slc3a2 Mertk Atp1b1 Atp1b3 Atp1b2 Thbd Pros1 Trem1 Mif Lck Slc7a11 Slc7a10 Cd48 L1cam Cd47 Bsg Slc7a6 Itga6 Slc7a7 Slc7a5 Slc7a8 Slc7a9 Itgav Cd74 Angpt1 F11r Ppia Procr Epcam Dok2 Plcg1 Sele Proc Selp Sell Jchain Cd44 Sirpa Itgb1 Tek Pecam1 Itgb3 Angpt2 Angpt4 Fcamr Inpp5d Pik3ca Shc1 Cav1 Mmp1b Ptpn6 Pik3r1 Pik3cb Pik3r2 Ptpn11 ENSRNOG00000069193 AABR07065813.1 F2 ENSRNOG00000062915 Igll1 ENSRNOG00000065191 Ighl12 ENSRNOG00000062682 ENSRNOG00000070812 ENSRNOG00000070415 ENSRNOG00000070810 ENSRNOG00000066926 ENSRNOG00000066406 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Ppil2 Iglc1 ENSRNOG00000070159 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 ENSRNOG00000066971 ENSRNOG00000063341 ENSRNOG00000065283 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Cxadr Igkvl13 AABR07065812.2 Selplg ENSRNOG00000063707 ENSRNOG00000067679 Itgax ENSRNOG00000070832 ENSRNOG00000064041 ENSRNOG00000064481 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 ENSRNOG00000063713 Pf4 ENSRNOG00000062820 ENSRNOG00000064886 ENSRNOG00000064490 Glg1 ENSRNOG00000066072 AABR07065781.1 ENSRNOG00000069901 ENSRNOG00000067603 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 Olr1 ENSRNOG00000067643 Slc16a3 Slc16a8 Slc16a1 Gas6 Mag Ceacam1 Jam3 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-RNO-400451.1 Free fatty acids regulate insulin secretion Plcb3 Gna11 Gna14 Plcb2 Plcb1 Cd36 Ffar1 Acsl3 Acsl4 Gnaq ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 96%10223549 Electric Transmission Across Gap Junctions Gja10 Gjc1 Gjd2 Panx2 Panx1 DEGRADATION OF GABA%REACTOME%R-RNO-916853.1 Degradation of GABA Aldh5a1 Abat SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-RNO-399955.1 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema3a Tln1 Fyn Nrp1 Plxna4 Plxna3 Plxna1 Farp2 Plxna2 Pip5k1c PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-RNO-428559.1 Proton-coupled neutral amino acid transporters Slc36a1 Slc36a2 ENOS ACTIVATION%REACTOME%R-RNO-203615.1 eNOS activation Nos3 Cygb Zdhhc21 Cav1 Calm3 Ddah1 Cyb5b Akt1 Spr Lypla1 Hsp90aa1 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-RNO-8963889.1 Assembly of active LPL and LIPC lipase complexes Lipc Angptl3 Furin Pcsk5 Angptl8 Pcsk6 Lmf1 Lpl Lmf2 Gpihbp1 Angptl4 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-RNO-69202.1 Cyclin E associated events during G1 S transition Ccnd1 Cdk7 Mnat1 Psma4 Ccna1 Psma3 Akt3 Ccna2 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Psmd14 Psmd13 Cdc25a Skp2 Skp1 Psmb5 Psmb4 Ptk6 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Cks1b Cables1 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Wee1 Ubb Ubc Psmb6l1 Cdkn1b Psmd7 Rb1 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Ccnh Cdk2 Cdk4 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%10222481 Post NMDA receptor activation events Creb1 Rps6ka6 Prkar2a Camk1 Prkar2b Prkaca Prkacb Rps6ka3 Camk4 Rps6ka1 Prkar1a Prkar1b Rps6ka2 Calm3 Camkk1 Camkk2 CS-GAG BIOSYNTHESIS%REACTOME%R-RNO-2022870.1 CS-GAG biosynthesis Bcan Vcan Chst3 Ust Ncan Cspg5 Bgn Dcn Cspg4 Chst15 Chst11 Chst12 Chsy1 Chsy3 Chst13 Chpf Csgalnact2 Chst7 Chst9 MAP2K AND MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%10224813 MAP2K and MAPK activation Il17rd Apbb1ip Fgb Fga Ksr1 Fgg Arrb2 Wdr83 Arrb1 Itga2b Araf Cnksr2 Map2k2 Csk Map2k1 Tln1 Pebp1 Fn1 Itgb3 Lamtor3 Lamtor2 Raf1 Vcl Braf Mark3 Mapk3 Src Nras Mapk1 Kras Rap1a Rap1b Hras Ywhab REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 96%10224531 Regulation of TP53 Activity through Association with Co-factors Zfp385a Tp53bp2 Phf20 Akt3 Akt2 Pou4f1 Akt1 Pou4f2 Banp Ppp1r13l Tp63 Ppp1r13b Tp73 Tp53 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME DATABASE ID RELEASE 96%10225351 STAT3 nuclear events downstream of ALK signaling Hdac2 Stat3 Hdac3 Hdac1 Ep300 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%10225097 RUNX1 regulates transcription of genes involved in interleukin signaling Cbfb Elf1 Runx1 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%10223237 AKT phosphorylates targets in the cytosol Cdkn1b Akt1s1 Mkrn1 Tsc2 Chuk Casp9 Akt3 Akt2 Akt1 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 96%10222219 Insulin receptor signalling cascade Ins2 Pdpk1 Frs2 Trib3 Grb10 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Them4 Pde3b Tlr9 Fgf17 Pik3ca Fgf18 Shc1 Insr Fgf19 Gab2 Fgf10 Mapk3 Akt2 Pik3r1 Pik3cb Pik3r2 Grb2 Sos1 Ptpn11 Fgf20 Fgf23 Fgf22 Pik3c3 Gab1 Irs2 Pik3r4 Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Mapk1 Kl Flt3 Ins1 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 96%10223033 Signaling by FGFR Ppp2cb Ppp2ca Hnrnph1 Frs2 Spred1 Plcg1 Frs3 Spred2 Fgfrl1 Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Fgfbp3 Fgf17 Fgfbp1 Pik3ca Fgf18 Shc1 Fgf19 Braf Rbfox2 Ppp2r1a Esrp2 Fgf10 Esrp1 Mapk3 Tial1 Tia1 Pik3r1 Src Spry2 Mknk1 Nras Rps27a Grb2 Kras Sos1 Polr2c Hras Polr2a Ptpn11 Polr2b Fgf20 Polr2g Fgf23 Polr2h Polr2e Fgf22 Polr2f Polr2i Gab1 Polr2j Ncbp2 Ncbp1 Tgfbr3 Uba52 Gipc1 Gtf2f2 Hnrnpa1 Gtf2f1 Klb Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Ubb Fgf8 Flrt1 Fgf7 Ubc Flrt3 Fgf9 Flrt2 Ptbp1 Cbl Mapk1 Hnrnpf Kl Galnt3 SIGNALING BY EGFR%REACTOME%R-RNO-177929.1 Signaling by EGFR Spry1 Ereg Uba52 Ptpn12 Plcg1 Btc Ptpn3 Csk Egf Eps15 Aamp Ubb Arhgef7 Ubc Hgs Pxn Eps15l1 Egfr Pik3ca Shc1 Fam83b Hbegf Pag1 Src Lrig1 Spry2 Pik3r1 Cbl Nras Rps27a Stam2 Fam83a Grb2 Fam83d Kras Epn1 Sos1 Sh3gl3 Hras Ptpn11 Sh3kbp1 Tgfa Stam Cdc42 Sh3gl2 Areg Sh3gl1 Gab1 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-RNO-3134973.1 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Crebbp Irf3 Ctnnb1 Ep300 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 96%10224387 MHC class II antigen presentation Lgmn Lag3 Actr1a Dctn1 Dctn2 Ifi30 Dctn4 Rilp Ctse Ctsf Ctso Racgap1 Ctsk Ctsl RT1-DOa Sec23a RT1-DOb Kif3a Kif26a RT1-DMb Kif11 Canx Kif15 Kif5a Kif5b Sptbn2 Ctsc Arf1 Sar1b Kif22 Sec31a Kif23 Ap1b1 Kif18a Kif20a Klc1 Ap1m2 Dync1h1 Kifap3 Ap1m1 Ap1s3 Klc4 Ap1s2 Actr10 Klc3 Dync1i2 Sec24d Klc2 Ap1g1 Sec24c Dync1i1 Sec24b Sec24a Kif3b Ctsb Ctsh RT1-Db2 Ctss Kif3c RT1-Db1 Dnm2 RT1-Ha RT1-Ba RT1-Bb Ap2m1 Rab7a RT1-Da Clta Ctsa Cenpe Cltc Dnm1 Kif2a Sec13 Kif2b Kif2c Dync1li2 Kif4b Dync1li1 Ap2s1 Kif4a Actr1b Dynll1 Ctsd Dynll2 Dnm3 Ap2a2 Ap2a1 Ap2b1 Sh3gl2 Cd74 Osbpl1a ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10223663 Association of TriC CCT with target proteins during biosynthesis Cct5 Sphk1 Cct4 Tcp1 Cct6b Cct7 Cct3 Cct6a Cct2 Cct8 ACTIVATION OF RAS IN B CELLS%REACTOME%R-RNO-1169092.1 Activation of RAS in B cells Kras Hras Rasgrp1 Nras DOWNSTREAM TCR SIGNALING%REACTOME%R-RNO-202424.1 Downstream TCR signaling Pdpk1 Prkcq Cdc34 Ube2d2 Inpp5d Pik3ca Psma4 Psma3 Psma6 Pik3r1 Psma5 Pik3cb Psma2 Psma1 Rps27a Pik3r2 Psmd12 Psmd11 Psmd14 Psmd13 Ikbkb Skp1 Psmb5 Psmb4 Traf6 Psmb7 Psmb6 Ikbkg Psmb1 Map3k7 Psmb3 Ube2n Psmb2 Uba52 Nfkb1 Pten Ube2d1 Fbxw11 Btrc Psma7 Rela RT1-Db2 Cd3g Psmc5 Cd247 Psmc2 RT1-Db1 Psmc1 Cd3e Psmc4 Cd3d Psmc3 Trav19 AC109737.1 Cd4 RT1-Ha Trat1 Lck RT1-Ba RT1-Bb Ubb ENSRNOG00000065955 Malt1 Ubc Trbv16 Bcl10 RT1-Da Ripk2 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Nfkbia Tab2 Chuk ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222041 Alanine metabolism Gpt2 Gpt CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%10225271 Class I peroxisomal membrane protein import Pxmp2 Fis1 Abcd1 Acbd5 Abcd2 Gdap1 Aldh3a2 Abcd3 Pex26 Pex11b Pex2 Atad1 Pex14 Pex13 Pex12 Pex19 Pex16 Pex3 Pxmp4 PI3K AKT SIGNALING%REACTOME%R-RNO-1257604.1 PI3K AKT Signaling Suz12 Erbb2 Eed Erbb3 Ereg Pdpk1 Frs2 Rbbp4 Btc Rbbp7 Tnks2 Pdgfa Pdgfb Xiap Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Creb1 Fgf17 Fgf18 Fgf19 Fgf10 Hbegf Mapk3 Ntrk3 Ntf3 Stub1 Rnf146 Grb2 Fyn Tnks Tgfa Fgf20 Wwp2 Fgf23 Areg Fgf22 Kit Traf6 Ppp2r5b Ppp2r5a Pip5k1b Kitlg Ppp2r5e Klb Irs1 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Lamtor3 Lamtor2 Hgf Egfr Hdac2 Irak1 Pdgfrb Pdgfra Chuk Kl Flt3 Nrg2 Nrg3 Met Prex2 Egf Trib3 Them4 Insr Rac1 Psma4 Akt3 Psma3 Akt2 Akt1 Psma6 Psma5 Psma2 Psma1 Chd3 Cd19 Rps27a Chd4 Psmd12 Psmd11 Tsc2 Psmd14 Psmd13 Mta1 Mta2 Mta3 Mbd3 Psmb5 Gatad2a Psmb4 Gatad2b Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Strn Psmc5 Psmc2 Psmc1 Psmc4 Esr2 Psmc3 Ubb Ubc Foxo3 Psmb6l1 Cdkn1b Psmd7 Rptor Psmd6 RragB Psmd8 Psmd2 Psmd1 Mtor Adrm1 Rheb Slc38a9 Mapk1 Lamtor5 Akt1s1 Lamtor4 Rraga Lamtor1 Rragc Pik3r6 Rragd Mlst8 Ins1 Ppp2cb Ins2 Ppp2ca Foxo4 Nedd4 Il33 Ppp2r5d Usp7 Il1rap Irak4 Mkrn1 Ppp2r1b Ppp2r1a Src Otud3 Pten Usp13 Lck Rhog Rac2 Ring1 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Esr1 Phc3 Csnk2a2 Trim27 Csnk2a1 Bmi1 Hdac1 Maf1 Mecom Sall4 Csnk2b Pik3ca Gab2 Pip5k1c Pik3r1 Pik3cb Rnf2 Pik3r2 Pik3r3 Vav1 Pik3cd Ptpn11 Gab1 Pml Pik3r5 Pik3cg Ier3 Irs2 Phlpp1 Pip4k2b Pip4k2c Pip4k2a Rps6kb2 Pik3ap1 Foxo6 Cd28 Icos Sgk1 Nr4a1 Ntf4 Pip5k1a Frk Rictor Cd86 Cd80 Prr5 Bdnf Il1rl1 Trat1 Casp9 Myd88 Mapkap1 Ntrk2 Foxo1 Ezh2 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%10224757 Lactose synthesis Slc2a1 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-RNO-390466.1 Chaperonin-mediated protein folding Csnk2b Sphk1 Rgs7 Pdcl Tcp1 Cct6b Cct7 Cct6a Gnb2 Gnb1 Gnb4 Cct8 Gnb3 Cct5 Gnb5 Cct4 Csnk2a2 Csnk2a1 Cct3 Cct2 Rgs9 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 96%10224675 Phase 0 - rapid depolarisation Cacna1c Cacng8 Cacnb1 Cacng6 Cacng7 Cacnb2 Cacng4 Cacna2d2 PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 96%10223431 PRC2 methylates histones and DNA Suz12 Hist1h2ai Eed Dnmt1 Rbbp4 Rbbp7 H2ac18 Phf19 Hist1h2bq Mtf2 Ezhip Aebp2 Ezh1 H2aj Epop H2ab2 H3-3b Hist3h2ba H2ac4 ENSRNOG00000068602 H2bc18 Dnmt3a ENSRNOG00000066901 H2az2 H2bc4 Ezh2 Hist1h4m Jarid2 H2bc1 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-RNO-674695.1 RNA Polymerase II Pre-transcription Events Iws1 Cdk7 Ell Ccnk Tcea1 Ccnt2 Ssrp1 Eloa2l Mnat1 Eloa Aff4 Taf9 Taf9b Taf15 Supt6h Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Taf7l-ps1 Gtf2a1 Gtf2a2 Cdc73 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Polr2c Taf4 Polr2a Taf2 Polr2b Taf1 Gtf2e2 Polr2g Polr2h Nelfa Polr2e Polr2f Nelfb Polr2i Nelfe Polr2j Ctdp1 Mllt3 Ncbp2 Mllt1 Ncbp1 Gtf2h2 Leo1 Gtf2h1 Supt4h1 Eloc Gtf2f2 Gtf2f1 Elob Gtf2h3 Gtf2h5 Ercc2 Ercc3 Nelfcd Cdk9 Skic8 Eaf1 Eaf2 Ccnh Ctr9 Paf1 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222071 Branched-chain amino acid catabolism Acad8 Auh Bckdk Mccc1 Echs1 Hibadh Mccc2 Dld Glyat Ppm1k Ivd Dbt Crat Bcat1 Bcat2 Hibch Aldh6a1 Hsd17b10 Bckdhb Acat1 Bckdha Acadsb EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-RNO-9619665.1 EGR2 and SOX10-mediated initiation of Schwann cell myelination Adgrg6 SIGNALING BY TGFBR3%REACTOME DATABASE ID RELEASE 96%10225437 Signaling by TGFBR3 Tgfb2 Aph1b Mmp16 Timp2 Tgfbr3 Gipc1 Arrb2 Inha Arrb1 Tgfbr1 Tgfbr2 Inhba Fgf2 Psenen Psen1 Psen2 Acvr2a Ncstn Mmp14 Aph1a Timp1 Tgfb1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-RNO-2565942.1 Regulation of PLK1 Activity at G2 M Transition Ywhag Cep135 Cep43 Actr1a Cep41 Cep131 Tubb4b Tubb4a Dctn1 Ninl Dctn2 Prkaca Rab8a Akap9 Ofd1 Prkar2b Ppp2r1a Hsp90aa1 Optn Rps27a Pafah1b1 Ccnb2-ps2 Skp1 Ppp1r12b Dync1h1 Ppp1r12a Ccnb1 Csnk1d Ccp110 Uba52 Dync1i2 Fbxw11 Btrc Ppp1cb Aurka Ajuba Nde1 Nedd1 Haus7 Tuba1a Haus8 Ubb Cdk5rap2 Cep192 Ubc Cep57 Nek2l1 Pcm1 Ssna1 Clasp1 Tubg1 Ywhae Cep63 Cep152 Tuba4a Plk1 Haus4 Haus5 Haus6 Pcnt Cul1 Sfi1 Haus1 Cdk1 Mapre1 Cep250 Dynll1 Cep290 Bora Cep78 Cep76 Cep72 Cep164 Cep70 Cpap Tubb5 Plk4 Ccnb2 Odf2 Ckap5 Alms1 Csnk1e Cetn2 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223691 Activation of AMPA receptors Gria4 Gria3 Gria2 Gria1 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-RNO-190840.1 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gja1 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-RNO-444411.1 Rhesus glycoproteins mediate ammonium transport Rhcg Rhbg Rhag CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-RNO-420499.1 Class C 3 (Metabotropic glutamate pheromone receptors) Tas2r16 Tas2r13 Tas2r135 Tas2r136 Tas2r140 Tas2r105 Tas2r145 Tas2r107 Tas2r119 Tas2r39 Tas2r4 Tas2r38 Tas2r3 Grm1 Grm3 Grm2 Tas2r7 Grm5 Gabbr1 Grm4 Grm7 Grm6 Casr Gabbr2 Grm8 Gprc6a Tas1r2 Tas1r1 Tas2r120 Tas1r3 Tas2r40 Tas2r41 RHOB GTPASE CYCLE%REACTOME%R-RNO-9013026.1 RHOB GTPase cycle Ophn1 Pcdh7 Myo9b Myo9a Actc1 Arhgap35 Vamp3 Racgap1 Dlc1 Stard13 Pkn2 Rock2 Rock1 Pkn1 Snap23 Tjp2 Arhgap32 Mcf2l Cav1 Arhgdig Flot2 Arhgef17 Flot1 Arhgef11 Pik3r1 Arhgef10 Arhgef12 Pik3r2 Akap13 Vav2 Arhgef25 Tfrc Arhgef5 Arhgef2 Arhgef1 Abr Slk Cavin1 Daam1 Ect2 Prex1 Bcr Jup Arhgap5 Sowahc Arhgap1 Stom Net1 Arhgef10l Mcam Rtkn Rhpn2 Stk10 Stard8 Rhob Anln Iqgap3 Diaph3 Diaph1 Depdc1b Cit Arhgef28 Arhgap21 Mcf2 Arhgap26 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-RNO-1299308.1 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Kcnk1 Kcnk7 Kcnk6 REGULATION OF TP53 DEGRADATION%REACTOME DATABASE ID RELEASE 96%10223239 Regulation of TP53 Degradation Rnf34 Ppp2cb Ppp2ca Phf20 Uba52 Pdpk1 Daxx Sgk1 Rictor Rffl Prr5 Chek2 Usp2 Mapkap1 Ubb Ubc Tp53 Usp7 Ccng1 Ppp2r1b Ppp2r1a Ccna1 Mtor Akt3 Ccna2 Akt2 Akt1 Cdk2 Atm Cdk1 Rps27a Mdm4 Mlst8 NEPHRIN FAMILY INTERACTIONS%REACTOME%R-RNO-373753.1 Nephrin family interactions Fyn Nck2 Kirrel1 Kirrel2 Kirrel3 Nphs1 Nck1 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%10222073 Histidine catabolism Aoc1 Carns1 Uroc1 Amdhd1 Carnmt1 Ftcd Hal Hdc GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-RNO-5610785.1 GLI3 is processed to GLI3R by the proteasome Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Prkaca Prkacb Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Gli3 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Sufu Skp1 Psmb5 Psmb4 Psmb7 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 96%10223883 Interleukin-27 signaling Il27 Canx Jak2 Crlf1 Tyk2 Stat3 Stat1 Il6st Ebi3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 96%10222819 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Ly96 Mapk11 Ticam2 Ticam1 Cd14 Tlr4 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-RNO-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) Psmb6 Psmb1 Psmb3 Psmb2 Gsk3b Uba52 Cd274 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Nek2l1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Rbx1 Cul1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cops5 Skp1 Psmb5 Psmb4 Psmb7 COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-RNO-8948216.1 Collagen chain trimerization Col3a1 Col28a1 Col22a1 Col5a2 Col5a3 Col24a1 Col5a1 Col20a1 Col15a1 Col11a1 Col11a2 Col13a1 Col19a1 Col18a1 Col2a1 Col27a1 Col7a1 Col23a1 Col26a1 Col14a1 Col8a1 Col25a1 Col10a1 Col8a2 SIGNALING BY RETINOIC ACID%REACTOME%R-RNO-5362517.1 Signaling by Retinoic Acid Cyp26a1 Rxrg Rdh11 Rdh10 Akr1c18 Rdh13 Akr1c12l1 Rdh14 Akr1c19 Adh4 Pdha1 Adh1 Akr1c21 Pdha2 Crabp1 Akr1c3l1 Crabp2 Aldh1a1 Akr1c12 Rdh7 Akr1c1 Akr1c13 Rara Akr1c9 Ppard Dld Dhrs4 Pdhx Dhrs3 Aldh8a1 Aldh1a2 Aldh1a3 Cyp26b1 Rarg Pdk4 Pdk3 Fabp5 Dhrs9 Cyp26c1 Dlat Pdk2 Sdr16c5 Pdk1 Pdhb Rxrb Rxra NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-RNO-975956.1 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps2 LOC134480579 Ncbp2 Ncbp1 Rpl23a Upf1 Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps27 Pabpc1 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 Rpl37 Rps4x-ps13 Rpl38 Rps3a Etf1 Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Gspt2 Gspt1 Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%10225393 Negative Regulation of CDH1 Gene Transcription Suz12 Hist1h2ai Eed Dnttip1 Rbbp4 Rbbp7 H2ac18 Ctbp2 Zeb1 Tle1 Hist1h2bq Hdac1 Mphosph8 Hdac2 H2aj H2ab2 Smarca4 Twist1 H3-3b Hist3h2ba Kmt5a H2ac4 ENSRNOG00000068602 Ctbp1 Sirt1 H2bc18 Zmym2 ENSRNOG00000066901 H2az2 H2bc4 Ezh2 Hist1h4m Kdm1a H2bc1 MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%10225073 MET receptor recycling Hgf Grb2 Rab4b Gga3 Arf6 Rab4a Met Crkl Crk Gab1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 96%10222557 Thrombin signalling through proteinase activated receptors (PARs) F2rl2 F2rl3 Arrb2 Arrb1 Gna11 Gna14 Gng3 Gng5 Gng4 Gnaq Gng7 Gng8 Gngt1 F2r Mapk3 Gnb2 Src Gnb1 Gnb4 Gnb3 Mapk1 Gnb5 Gng11 Gng10-ps1 F2 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 96%10223303 Synthesis of very long-chain fatty acyl-CoAs Elovl2 Elovl3 Tecr Acsbg1 Elovl5 Elovl1 Elovl6 Acsbg2 Elovl7 Tecrl Hsd17b3 Acsf3 Hsd17b12 Hacd1 Acsl1 Hacd2 Acsl5 Hacd3 Acsl6 Hacd4 Acsl3 Acsl4 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224633 B-WICH complex positively regulates rRNA expression Sf3b1 Hist1h2ai Gsk3b Ddx21 Dek H2ac18 Baz1b Polr1c Myo1c Hist1h2bq Actg1 Kat2a H2aj H2ab2 Tbp Polr1b H3-3b Polr1a Hist3h2ba Polr1f Ep300 H2ac4 Polr1g Polr1e ENSRNOG00000068602 Polr1h Taf1d Mybbp1a Taf1a Taf1c Taf1b H2bc18 Polr2h Kat2b ENSRNOG00000066901 H2az2 Smarca5 Polr2e Polr2f H2bc4 Ercc6 Hist1h4m H2bc1 TRYPTOPHAN CATABOLISM%REACTOME%R-RNO-71240.1 Tryptophan catabolism Slc3a2 Kmo Ido1 Aadat Kynu Kyat1 Slc7a5 Tdo2 Slc36a4 Haao Ido2 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 96%10224533 Regulation of TP53 Activity through Acetylation Pip4k2b Pip4k2c Pip4k2a Rbbp4 Rbbp7 Ing2 Ing5 Brd1 Brpf3 Brd7 Map2k6 Hdac1 Tp53 Hdac2 Pip4p1 Brpf1 Akt3 Akt2 Kat6a Akt1 Ep300 Meaf6 Chd3 Chd4 Mta2 Mbd3 Gatad2a Pml Gatad2b DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 96%10223951 Deposition of new CENPA-containing nucleosomes at the centromere Hist1h2ai Itgb3bp Rsf1 Oip5 Mis18a Rbbp4 Cenpc Rbbp7 Cenpw Cenpa H2ac18 Cenpu Cenpt Cenpq Cenpp Cenpo Cenpn Hist1h2bq Cenpm Cenpl Cenpk Cenpi Cenph Ruvbl1 Npm1 H2aj H2ab2 Hist3h2ba H2ac4 ENSRNOG00000068602 Knl1 Mis18bp1 Hjurp ENSRNOG00000066901 H2az2 Smarca5 H2bc4 Hist1h4m H2bc1 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-RNO-2161517.1 Abacavir transmembrane transport Slc22a3 Slc22a2 Slc22a1 MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%10224911 MET Receptor Activation Hgfac Hgf Hpn Spint2 Spint1 Met YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%10224379 YAP1- and WWTR1 (TAZ)-stimulated gene expression Tead2 Tead4 Wwtr1 Kat2b Tbx5 Yap1 Tead3 TIE2 SIGNALING%REACTOME%R-RNO-210993.1 Tie2 Signaling Grb7 Pik3ca Shc1 Dok2 Grb14 Pik3r1 Pik3cb Nras Grb2 Pik3r2 Kras Sos1 Hras Ptpn11 Tek Angpt2 Angpt4 Angpt1 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 96%10225311 Estrogen-stimulated signaling through PRKCZ Mapk1 Prkcz Kras Hras Pdpk1 Nras INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-RNO-445095.1 Interaction between L1 and Ankyrins Sptbn4 Spta1 L1cam Sptb Sptbn1 Ank1 Sptbn2 Sptan1 Sptbn5 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 96%10224969 Interleukin-36 pathway Il1rap Il1rl2 Il1f10 Il36a Il36rn Il36g CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-RNO-9855142.1 Cellular responses to mechanical stimuli Ppp2ca Pdpk1 Stat1 Prkaca Prkacb Gna11 Prkar1a Anxa2 Prkar1b Adm Itgb1 Calm3 Gng3 Itgb3 Gng5 Pkn2 Gng4 Gnaq Gng7 Pde4d Capn2 Gng8 Gngt1 Prkar2a Prkar2b Ppp2r1b Ppp2r1a Ptk2 Capns1 Yap1 Akt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Ikbkb Gnas Calcrl Ikbkg Ppp2r2a Nfkb1 Rela Rictor Prr5 Mapkap1 P2ry2 Vcl Ptpn1 Mtor Ikbke Nfkbia Nos3 Trpv4 Ramp2 Gng10-ps1 Chuk Abl1 Itgav Mlst8 METABOLISM OF LIPIDS%REACTOME DATABASE ID RELEASE 96%10222085 Metabolism of lipids Phyh Amacr Eci2 Hacl1 Mlycd Scp2 Prkab2 Gnpat Crat Acox1 Acox2 Ehhadh Acox3 B3gnt5 Pi4kb Pik3c2g Acaa1b Tpte2 Hsd17b4 Hao2 Pecr Acbd5 Slc27a2 Aldh3a2 Decr2 Crot Nudt19 Acot1 Acot2 Acot5 Acot3 Acot4 Acot8 Abcd1 Baat Echs1 Hadh Agps Cbr1 Hmgcl Tbxas1 Ptges Ptgds Ptgis Ptges2 Ptgs1 Kpnb1 Ormdl3 Mapkapk2 Cyb5b Ch25h Ran Osbpl3 Gpx2 Osbpl2 Osbpl1a Aloxe3 Gpx1 Osbpl7 Osbpl6 Alox12b Cyp39a1 Osbpl9 Hsd3b7 Ncoa2 Akr1d1 Agpat2 Cyp8b1 Cyp7b1 Slc10a1 Alpi Fabp6 Nr1h4 Abcc3 Cpne1 Stard5 Cpne3 Cyp46a1 Cyp27a1 Osbp Slc27a5 Slc51a Cyp7a1 Slc51b Inpp5j Abcb11 Synj1 Akr1b1 Them4 Sbf1 Degs1 Synj2 Inpp5f Pi4k2b Inpp4a Pikfyve Inpp4b Pik3c2a Pik3c3 Mtm1 Fig4 Agpat3 Acoxl Slc44a3 Vac14 Mtmr12 Slc44a4 Slc44a5 Pi4k2a Mtmr4 Slc44a1 Cyp24a1 Pik3r4 Cyp27b1 Slc44a2 Rab5a Rab4a Ndufab1 Fdx1 Awat2 Slc22a5 Awat1 Dhrs7b Far2 Far1 Pla2g6 Plekha6 Plekha5 Plekha4 Plekha3 Plekha2 Plekha1 Tnfaip8l2 Cyp2j16 Tnfaip8l3 Fdps Tnfaip8l1 Plpp6 Rufy1 Cyp4f39 Idi1 Pitpnb Hsd17b7 Cyp2j3 Inpp5k Mvk Cyp4f1 Pik3c2b Fdft1 Cyp4a14 Sqle Mgll Bmx Ebp Cyp4f3 Tnfaip8 Mtmr7 Hmgcs1 Cyp4a12 Mtmr6 Arv1 Cyp4f40 Mtmr9 Ggps1 Cyp4b1 Sc5d Cpt1a Pik3r6 Lbr Mid1ip1 Acat2 Cyp4f4 Thrsp Nsdhl Cpt2 Cyp4a10 Dhcr24 Cpt1b Cyp4a2 Slc25a20 Dhcr7 Lss Tm7sf2 Srebf2 Pmvk Hmgcr Mvd Msmo1 Srebf1 Pcyt2 Cept1 Etnk2 Etnk1 Etnppl Chka M6pr Chkb Rab14 Selenoi Phospho1 Sacm1l Ggt1 Pi4ka Ggt5 Hpgds Pias4 Arsa Ube2i Smpd2 Smpd3 Cyp1b1 Smpd4 Chat Smpd1 Gba1 Gba3 Lhb Cga Gba2 Enpp7 Galc Asah2 Asah1 Sts Gm2a Arsl Arsk Arsj Arsi Arsg Gla Sumf1 Arsb Sumf2 Mecr Mtmr14 Fut2 Fut1 Mtmr3 B3galt4 Cyp21 Cyp11b3 Cds1 Cdipt Pitpnm2 Pitpnm3 Pitpnm1 Lgmn Sumo3 Hadha Hadhb Acadl Gstm4 Ltc4s Inpp5d Pik3ca Pip5k1c Pik3r1 Pik3cb Pik3r2 Pik3r3 Inppl1 Pik3cd Med1 Cyp11b1 Cyp11b2 Cyp19a1 Plekha8 Pik3r5 Pik3cg Alox12 Cyp3a9 Alox5ap Gpx4 Hpgd Alox5 Lta4h Alox15 Cyp3a18 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Ephx2 Cyp3a1 Cyp1a2 Cyp2d4 Pnpla2 Cyp3a62 Mbtps1 Cyp3a2 Ptgs2 Lpcat4 Lpgat1 Lpcat1 Pla2g3 Crls1 Mfsd2a Pcyt1b Pcyt1a Abhd3 Pemt Chpt1 Stard10 Gpd1l Abhd4 Osbpl10 Miga2 Miga1 Gpd1 Tgs1 Pgp Mboat1 Mboat2 Osbpl5 Pld6 Pla1a Osbpl8 Cpne6 Cpne7 Liph Lipi Cds2 Acat1 Acp6 Gpat4 Gpat3 Lpcat3 Lpcat2 Tmem86b Pnpla8 Plaat1 Plaat5 Agk Ddhd2 Agpat4 Fabp1 Agpat1 Akr1c18 Abcg2 Abcc1 Akr1c12l1 Akr1c19 Hsd3b Hsd17b3 Gc Akr1c21 Cyp17a1 Hsd3b6 A4galt Hsd3b5 Cerk Hsd11b1 B3galnt1 Srd5a3 Hsd11b2 Hsd3b1 Ugcg B4galnt1 Srd5a1 Ugt8 Hsd17b12 Gal3st1 Srd5a2 Hsd3b5-ps1 Serpina6 Akr1c3l1 Lpin3 Akr1c12 Lpin2 Akr1c1 Akr1c13 Alb Akr1c9 Mtmr1 Hsd17b11 Hsd17b14 Hsd17b1 Hsd17b2 Akr1b7 Lrp2 Plb1 Pip5k1b Akr1b10 Dgat2l6 Dgat2 Dgat1 Pnpla3 Pon3 Pon1 Pld1 Glb1l B4galt5 B4galt6 Glb1l3 Glb1l2 Hexa Hexb Pla2g4f Pla2g2d Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Pla2g4d Ocrl Plbd1 Pla2r1 Pla2g12a Mboat7 Cyp2u1 Pla2g10 Hacd1 Plaat3 Hacd2 Pla2g5 Pld2 Hacd3 Hacd4 Hsd17b8 Dpep1 Dpep2 Mcat Acad11 Elovl2 Acly Stard4 Elovl3 Star Stard6 Acaa2 Elovl5 Cyp11a1 Tspo Elovl1 Fdx2 Elovl6 Fdxr Elovl7 Tecrl Faah Acbd6 Acbd4 Ppt2 Ppt1 Acsf3 Acsf2 Dbi Acot11 Scd1 Acot12 Ptpn13 Acot13 Them5 Acot9 Acot7 Acsl1 Acsl5 Acsl6 Acsl3 Acsl4 Fads2 Rxra Ldlrap1 Pon2 Fads1 Sphk1 Acadvl Alox15b Cbr4 Tecr Acsbg1 Tbl1x Pctp Acads Acsbg2 Scap Acaca Fasn Mmut Cubn Hdac3 Tbl1xr1 Ppard Pcca Fabp2 Fabp3 Pccb Fabp4 Gk Ptges3 Fabp7 Mogat1 Ncor2 Pnpla5 Gpat2 Carm1 Pnpla4 Mogat2 FABP12 Gpam Gpd2 Agmo Fabp9 Gykl1 Pla2g4a Fabp5 Mmaa Tafazzin Lclat1 Pomc Oxct2a Acss3 Bdh2 Bdh1 Oxct1 Hmgcll1 Hmgcs2 Aacs Arf3 Arf1 Pten Eci1 Acadm Decr1 Acer1 Acer2 Aldh3b1 Sgpl1 Aldh3b2 Acer3 Sgpp2 Plpp2 Plpp3 Plpp1 Sgpp1 Tspoap1 Psap Stard7 Morc2 Vdr Crebbp Inpp5e Ppara Sin3a Sin3b Csnk2a2 Csnk2a1 Mfsd2b Sptssa Cers6 Csnk2b Cers5 Cers4 Cers3 Cers2 Sgms1 Sgms2 Sptlc1 Sptlc2 Sptlc3 Fa2h Sphk2 Spns2 Kdsr Degs2 Ormdl2 Smarcd3 Ptdss1 Ptdss2 Cidea Pla2g15 Cidec Pla2g4b Hsd17b13 Fitm2 Fitm1 Pip4k2b St8sia5 Pip4k2c Pip4k2a Neu2 Neu3 Neu4 Neu1 St6galnac5 St6galnac6 Pip5k1a St3gal5 St3gal2 St3gal3 Glb1 Ctsa Pip4p1 Prkaa2 Prkag2 Gde1 Pnpla6 Enpp6 Slco1a4 Slco1b2 HDL CLEARANCE%REACTOME%R-RNO-8964011.1 HDL clearance Scarb1 Cubn Amn Apoa1 Hdlbp INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-RNO-512988.1 Interleukin-3, Interleukin-5 and GM-CSF signaling Prkaca Syk Hck Stat5a Stat5b Tec Inpp5d Jak2 Pik3ca Shc1 Il2ra Il2rb Ptpn6 Gab2 Il2 Il3 Il5 Lyn Crkl Csf2rb Yes1 Rapgef1 Pik3r1 Pik3cb Cbl Csf2 Jak3 Grb2 Pik3r2 Fyn Pik3r3 Inppl1 Vav1 Pik3cd Sos1 Ptpn11 Crk Ywhaz NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME DATABASE ID RELEASE 96%10225279 Negative regulation of NOTCH4 signaling Notch4 Akt1 RHO GTPASES ACTIVATE CIT%REACTOME%R-RNO-5625900.1 RHO GTPases activate CIT Rhoc Kif14 Cit Rac1 Prc1 Rhob Dlg4 Rhoa RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 96%10225043 RUNX1 regulates transcription of genes involved in differentiation of HSCs Cbfb Cdk7 Kmt2a Tcf3 Mnat1 Tal1 Psma4 Psma3 Yap1 Psma6 Psma5 Psma2 Psma1 Itch Rps27a Psmd12 Tcf12 Psmd11 Psmd14 Psmd13 Runx1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Lmo2 Adrm1 Lmo3 Ccnh Gata3 Gata1 Gata2 Abl1 Tp73 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME DATABASE ID RELEASE 96%10224999 The role of GTSE1 in G2 M progression after G2 checkpoint Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Gtse1 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Tp53 Psmb6l1 Psmd7 Psmd6 Psmd8 Hsp90ab1 Plk1 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Fkbpl Psma5 Cdk1 Psma2 Hsp90aa1 Psma1 Rps27a Mapre1 Psmd12 Psmd11 Psmd14 Psmd13 Ccnb2-ps2 Ccnb2 Psmb5 Psmb4 Psmb7 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-RNO-210745.1 Regulation of gene expression in beta cells Foxo1 Akt3 Akt2 Akt1 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-RNO-1660661.1 Sphingolipid de novo biosynthesis Sptssa Cers6 Sphk1 Cers5 Cers4 Cers3 Cers2 Sgms1 Abcg2 Sgms2 Sptlc1 Abcc1 Sptlc2 Cyb5b Sptlc3 Fa2h Sphk2 Spns2 Kdsr Degs2 Degs1 Ormdl2 Mfsd2b Ormdl3 METABOLISM OF POLYAMINES%REACTOME%R-RNO-351202.1 Metabolism of polyamines Psmb6 Psmb1 Psmb3 Psmb2 Azin2 Psma7 Amd1 Psmc5 Psmc2 Psmc1 Psmc4 Smox Psmc3 Sat1 Srm Psmb6l1 Psmd7 Agmat Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Odc1 Oaz1 Psmd12 Oaz3 Psmd11 Oaz2 Psmd14 Nqo1 Psmd13 Azin1 Psmb5 Psmb4 Psmb7 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 96%10224181 Phase 4 - resting membrane potential Kcnk5 Kcnk4 Kcnk2 Kcnj4 Kcnk1 Kcnk10 Kcnk16 Kcnk9 Kcnj2 Kcnk7 Kcnj14 Kcnk18 Kcnk6 Kcnj12 Kcnk13 Kcnk12 Kcnk15 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222461 GPCR downstream signalling Rgs3 Rgs1 Rgs8 Rgs7 Pcp2 Gpsm3 Gpsm2 Gpsm1 Rgs21 Rgs18 Prkcq Rgs19 Rgs13 Rgs14 Gnat2 Rgs12 Ccr1l1 Lpar5 S1pr3 S1pr2 S1pr5 Lpar3 S1pr4 Lpar1 Creb1 Hbegf Mapk3 Nras Grb2 Kras Sos1 Hras App Mapk7 Rps6ka3 Rps6ka1 Rps6ka2 Egfr Rasgrf2 Gna12 Itgb1 Pde3b Akt3 Akt2 Akt1 Prkch Prkce Grk3 Mgll Pik3r6 Dgka Dgkb Abhd6 Dgkd Dgke Dgkg Dgkh Dgki Dgkk Dgkq Dgkz Itpr3 Itpr2 Itpr1 Pak1 Pde10a Daglb Src Rhoa Ngef Trpc7 Trpc3 Dagla Pde11a Arrb2 Arrb1 Pde3a Pde7a Grk5 Grk6 Pde8a Pde8b Rhob Agt Npffr1 Npffr2 Npff Abhd12 Hcrtr2 Hcrtr1 Qrfprl Qrfpr Qrfp Hcrt Pde2a Pik3ca Shc1 Pik3r1 Pik3r2 Pik3r3 Pik3r5 Pik3cg Pdpk1 Ednrb Ednra Plxnb1 Rrh Apln Trhr Tas2r39 Oprd1 Tas2r38 C3ar1 Galr2 Galr3 Galr1 Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Avpr1b Rxfp3 Avpr1a Htr5a Tbxa2r Gpr183 Ppbp Fpr1 Btk Gnrh1 Tas1r2 Tas1r1 Nmbr Fpr2 Ccr10 Tas1r3 C3 C5 Ptgfr Pnoc Tas2r16 Tas2r13 Rhoc Ppy Tas2r135 Tas2r136 Nmb Oxtr Lpar6 Xcr1 Gpr18 Grpr Gpr17 Nms Tas2r140 Nmu Tas2r145 Cckar Npbwr1 Nmur2 Gnrhr Nmur1 Ntsr2 Ntsr1 Tas2r4 Tas2r3 Rock2 Arhgef7 Brs3 Rock1 Tas2r7 Gabbr1 Ptger3 Gabbr2 Ptger1 Ccr9 Ccr8 Ccr7 Mchr1 Ccr6 Ccr5 Ccr4 Ccr3 Gpr132 Edn1 Gast Edn2 Edn3 Cckbr Mtnr1b Agtr1 Agtr2 F2 Gpr37 Gpr39 Gal Penk Avp Rgr Npb Gpr143 Grp Opn1mw Kiss1r Gcgr Ccl19 Nps Ccl11 Ptafr Npw Npy Ptgdr2 Rho Mmp3 Pf4 Cx3cl1 Gprc6a Fpr2l3 Cysltr2 Cysltr1 Prok2 Gpr4 Gcg Ccl27 Npsr1 Plcb4 Prok1 Plcb3 P2ry10 Mapk1 Pla2g4a Pdyn Plcb2 P2ry13 Plcb1 P2ry12 Ccl20 Ppp1r1b Gpr55 Gng10-ps1 Adcy3 Ccl21 Adcy4 P2ry14 Adcy1 Adcy2 Mcf2 F2rl1 Tas2r40 Camkk1 Adcy7 Fpr2l1 Tas2r41 Camkk2 Adcy8 Ppp1ca F2rl2 Adcy5 F2rl3 Adcy6 Hcar1 Ppp2cb Prokr2 Ppp2ca Adra2b Adcy9 Hcar2 Prokr1 Pde4a Cxcr1 Pde4b Cxcr2 Prkaca Cxcr3 Prkacb Prkcg Npy1r Prkcd Gpr65 Oprm1 Gpr68 Gnai2 Gnai1 Cxcr4 Prkca Cxcr5 Gnai3 Oprl1 Gna11 Camk4 Adrb2 Prkar1a Adra1b Gna14 Prkar1b Calm3 Adra1a Ppp2r5d Adra1d Gng3 Uts2 Grk2 Gnal Pomc Tacr1 Gng5 Tacr3 Gng4 Tacr2 Pde4c Anxa1 Gnaq Cxcl11 Gng7 Hebp1 Pde4d Gng8 Gngt1 Cxcl12 Casr Gnat3 Prkar2a Cxcl10 Prkar2b F2r Ppp2r1b Ppp2r1a C5ar1 Ffar3 Cdk5 Pde1b Aplnr Bdkrb2 Pde1c Ffar1 Gnb2 Bdkrb1 Gnb1 Ffar2 Pde1a Nts Gnb4 Kng1 Gnb3 Gnb5 Chrm1 Gng11 Hrh1 Chrm3 Chrm2 Chrm5 Hrh4 Chrm4 Tac3 Tac1 Drd3 Drd4 Opn4 Opn3 Pmch Gper1 Oxgr1 Adra2a Opn5 Sucnr1 Pyy Adora1 Adra2c Adora3 Rln3 Ltb4r2 Cxcl16 Cxcl13 Tas2r119 Opn1sw Oxt Trh P2ry2 Npy5r Grm1 Grm3 Grm2 Grm5 Grm4 Grm7 Grm6 Ffar4 Grm8 Htr2a Ghrl Htr2c Htr2b Lpar4 Ltb4r Npy4r Cx3cr1 Psap Htr1d Htr1f Tas2r120 Xcl1 Htr1b Kiss1 Ccl9 P2ry6 Cxcl9 P2ry4 Ccl6 Ccl5 P2ry1 Ccl4 Ccl1 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Uts2b Tas2r105 Tas2r107 Gpr37l1 Ackr3 Cck Cnr1 Cnr2 Uts2r Sst Oprk1 Tiam1 Mcf2l Tiam2 Arhgef15 Arhgef17 Arhgef16 Arhgef11 Arhgef10 Arhgef12 Arhgef19 Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 Sos2 Kalrn Rgs9 Arhgef6 Arhgef5 Arhgef4 Arhgef2 Gna13 Arhgef1 Obscn Fgd2 Arhgef9 Fgd1 Fgd4 Gnat1 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Plekhg5 Plekhg2 Net1 Arhgef10l Rgs20 Rgs17 Rgs16 Gnaz Cdc42 Rgsl1 Ghsr Rgs4 Rgs5 Rgs2 STRIATED MUSCLE CONTRACTION%REACTOME%R-RNO-390522.1 Striated Muscle Contraction Tmod3 Tnni3 Tmod1 Tmod4 Tmod2 Tnni2 Tnni1 Tpm4 Myl4 Tpm2 Myl1 Myl2 Tpm1 Myl3 Neb Tnnt3 Tnnt2 Tnnt1 Tnnc2 Tnnc1 Dmd Myh3 Actn3 Myh6 Tcap Des Mybpc2 Mybpc3 Actn2 Vim SIGNALING BY ERYTHROPOIETIN%REACTOME DATABASE ID RELEASE 96%10225159 Signaling by Erythropoietin Pik3r5 Pik3cg Irs2 Pik3ca Epor Jak2 Shc1 Lyn Crkl Rapgef1 Pik3r1 Pik3cb Grb2 Vav1 Pik3cd Epo Gab1 APOPTOTIC EXECUTION PHASE%REACTOME%R-RNO-75153.1 Apoptotic execution phase Ocln Casp7 Ctnnb1 Prkcq Prkcd Birc2 Plec Bcap31 Gsn Casp6 Satb1 Gas2 Sh3glb2 Add1 Rock1 Tjp2 Ptk2 Stk26 Sptan1 Stk24 Dnm1l Lmnb1 Acin1 Vim Apc Mapt Tjp1 Dsg3 Cdh1 Dsp Casp3 Dsg1 Dsg2 Kpnb1 Hmgb1-ps34 Kpna1 Clspn Casp8 Pkp1 Hmgb1l2 Hmgb1l1 H1-1 Lmna H1-0 Bmx H1-5 H1-4 H4f3 Hmgb2 Fnta Dffa Dffb BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME DATABASE ID RELEASE 96%10225233 Biosynthesis of DHA-derived sulfido conjugates Gstm4 Ltc4s FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 96%10225339 Formation of WDR5-containing histone-modifying complexes Paxip1 Kat14 Phf20 Mbip Hcfc1 Kmt2d Hcfc2 Dr1 Kansl3 Kmt2a Kansl1 Kmt2b Kansl2 Kmt2c Phf20l1 Bod1l1 Pagr1 Men1 Tada3 Tada2a Mcrs1 Zzz3 Sgf29 Psip1 Ogt Wdr5 Ash2l Kat2a Tasp1 Akap8l Setd1b Cxxc1 Setd1a Kat8 Kat2b Yeats2 Rbbp5 Wdr82 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME%R-RNO-2995383.1 Initiation of Nuclear Envelope (NE) Reformation Ccnb1 Ppp2r2a Ppp2ca Vrk2 Ppp2r1a Vrk1 Cdk1 Emd Lmna Sirt2 Lmnb1 Ccnb2-ps2 Lbr Banf1 Ccnb2 Ankle2 Kpnb1 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-RNO-5655862.1 Translesion synthesis by POLK Rev1 Rev3l Rfc5 Uba52 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Rps27a Rpa1 Rpa2 Polk Ubb Rpa3 Ubc Mad2l2 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME%R-RNO-9764560.1 Regulation of CDH1 Gene Transcription Suz12 Hist1h2ai Eed Dnttip1 Rbbp4 Rbbp7 H2ac18 Ctbp2 Zeb1 Tle1 Hist1h2bq Hdac1 Mphosph8 Hdac2 H2aj H2ab2 Smarca4 Twist1 H3-3b Hist3h2ba Kmt5a H2ac4 ENSRNOG00000068602 Ctbp1 Sirt1 H2bc18 Zmym2 ENSRNOG00000066901 H2az2 H2bc4 Ezh2 Hist1h4m Kdm1a H2bc1 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME%R-RNO-5685942.1 HDR through Homologous Recombination (HRR) Slx4 Spidr Rad51 Rad50 Rbbp8 Brca2 Brca1 Rad51ap1 Polk Polh Rps27a Blm Wrn Dna2 Mre11 Uba52 Eme2 Kat5 Eme1 Nbn Gen1 Rad51c Pole3 Rad51b Pole2 Chek1 Pole4 Rpa1 Rpa2 Bard1 Top3a Ubb Rpa3 Palb2 Ubc Firrm Pole Rfc5 Xrcc3 Pold2 Slx1b Pold1 Xrcc2 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Atm Pold4 Pold3 Exo1 Mus81 Rmi2 Fignl1 Rmi1 Brip1 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-RNO-9029569.1 LXRs regulate gene expression linked to cholesterol transport and efflux Abca1 Tbl1x Ncor2 Hdac3 Nr1h3 Nr1h2 Tbl1xr1 Gps2 Ep300 Rxrb Rxra METHIONINE SALVAGE PATHWAY%REACTOME%R-RNO-1237112.1 Methionine salvage pathway Mri1 Mtap Enoph1 Adi1 INTERLEUKIN-21 SIGNALING%REACTOME%R-RNO-9020958.1 Interleukin-21 signaling Jak3 Stat3 Stat1 Il21 Stat5a Stat5b METABOLISM OF PROTEINS%REACTOME%R-RNO-392499.1 Metabolism of proteins LOC120093247 Rgs7 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Fut8 Fuca1 Rpl13 Man2a1 Rpl14 Man2a2 Rpl15 Mgat2 Rpl17 Rpl18 Suclg2 Rpl19 Rpl10 Rpl11 Cs Rpl12 Rpl10a Fh Aco2 Idh3a Nop58 LOC134480579 Commd9 Rpl23a Ceacam6 Cgm4 Commd3 Rab44 Rab37 Psgb1 Rab3d Fcgr3a Psg29 Tf Hspa8 Mgat5 Mgat1 Mgat3 Manea Man1c1 Man1a2 Man1a1 Mgat4c Mgat4b Alas1 Fech Mvd Lrr1 Fbxl21 Wsb1 Ccnf Lypd6b Rtn4rl2 Gpld1 Cdc34 Lypd8 Tecta Lypd5 Lypd4 Lypd3 Negr1 Tex101 Lypd2 Lypd1 Alpl Opcml Tectb Dpm1 Dpm3 Otoa Izumo1r Ube2g2 Ly6g6d Cd52 Ube2g1 Prss21 Nrn1 Ntm Gp2 Kbtbd8 Xpnpep2 Fbxw4 Thy1 Fbxw5 Art4 Fbxw7 Art3 Gan Atrnl1 Fbxw8 Fbxw9 Lsamp Reck Sprn Plet1 Fbxw2 Psca Klhl5 Spaca4 Cntn4 Mdga1 Klhl3 Cntn3 Mdga2 Klhl2 Cntn5 Spsb2 Ly6e Ly6h Prnd Spsb1 Ly6d Prss41 Spsb4 Eloc Elob Kctd7 Kctd6 Ube2w Ube2m Ube2k Ltn1 Pdia3 Ube2b Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Fbxo17 Lmo7 Lrrc41 Klhl13 B4galnt2 Klhl11 Ube2z Fbxo21 Fbxo22 Fbxo27 Msra Pcmt1 Uba6 Msrb1 Msrb3 Fbxw17 Msrb2 Klhl25 Ube2e3 Klhl21 Btbd6 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Zbtb16 Uba1 Cul2 Cul5 Cul7 Fbxo41 Fbxo44 Oxsm Htra2 Aldh2 Lonp1 Aldh1b1 Klhl41 Clpp Iars2 Fbxo40 Clpx Btbd1 Fbxo2 Asb12 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Ube2r2 Fbxo4 Fbxo6 Fbxo7 Fbxo9 Vhl Fbxl15 Fbxl16 Fbxl19 Pdcl Cct6b Asb9 Asb7 Asb6 Dhdds Nudt14 Asb5 Alg5 Asb4 Dolpp1 Fuom Rchy1 Gmds Dolk Asb1 Fcsk Dhrsx Nus1 Fpgt Gfus Ogfod1 Riox1 Kdm8 Rccd1 Jmjd4 Drg1 Zc3h15 Jmjd7 Ube2t Otulin Dhps Eif5a Fn3k Fn3krp Eif5a2 Dohh Notum Alg9 Alg8 Alg6 Alg3 Alg2 Alg13 Alg14 Alg12 Mpdu1 Dpagt1 Amfr Engase Ngly1 Ktn1 Star Psmg1 Psmg4 Psmg3 Psma4 Psmd10 Ccna1 Pomp Psma3 Psmd5 Psmd4 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Dtl Psmd11 Ube2c Psmd14 Psmd13 Mta1 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Dnajc3 Psmb1 Psmb3 Psmb2 Uba52 Nub1 Neurl2 Ube2d1 Commd8 Fem1b Fem1a Btrc Tulp4 Psma7 Fem1c Dcaf8 Dcaf4 Aurkb Dcaf5 Psmc5 Dcaf6 Psmc2 Dcaf7 Ccdc22 Psmc1 Psmc4 Obsl1 Psmc3 Dda1 Ccdc8 Commd4 Commd5 Commd6 Commd7 Commd2 Spsb3 Ubb Ankrd9 Socs2 Ubc Commd10 Socs6 Ube2e1 Psmb6l1 Ubd Wdtc1 Npm1 Psmd7 Dcun1d5 Dcun1d4 Psmd6 Dcun1d3 Psmd8 Cish Dcun1d2 Psmd2 Dcun1d1 Cul9 Psmd1 Dcaf17 Adrm1 Dcaf10 Dcaf11 Cul1 Cdk1 Epas1 Hif3a Prkaca Rab2b Rab34 Rab20 Igfbp3 Ptp4a2 Rab23 Rab26 Rab25 Calm3 Rab29 Rab40b Rab15 Rab17 Rab19 Pomc Rab3c Rab3b Mettl22 Etfbkmt Kin Mettl21a Eef2kmt Eef1akmt2 Eef1akmt1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Muc15 Muc13 Muc19 Umod Muc5b Muc4 Asgr2 Muc6 Asgr1 Slc34a1 Adra2a Adora2b Adgrf5 Adora2a Adra2c Ctsh Slc34a2 Dmbt1 Sftpa1 Ttf1 Lmcd1 Sftpb Napsa Sftpd Sftpc Ccdc59 Abca3 P2ry2 Gata6 Zdhhc2 Ckap4 Tp53 Skic8 Polb Parp1 H2ac4 Actl6a Gata3 Ring1 ENSRNOG00000066901 Phc2 Phc1 Cbx4 Ttll6 Ttll7 Cbx2 Ttll4 Esr1 Phc3 Ttll5 Ttll10 Ttll2 Ttll3 Ttll11 Ttll12 Ttll8 Ttll13 Ttll9 H2ac18 Sin3a Csnk2a2 Csnk2a1 Bmi1 Hist1h2bq Hdac1 Wdr5 Csnk2b Ep300 Rnf2 ENSRNOG00000068602 Kat2b Rbbp5 H2bc4 Hist1h4m H2bc1 Pml Hist1h2ai St8sia6 Etf1 St8sia4 St8sia5 Npl Neu2 Neu3 Neu4 Neu1 Cmas St6galnac5 St6galnac6 Slc17a5 St6galnac3 St6galnac1 St3gal6 St6galnac2 St3gal4 St3gal5 St3gal2 St3gal3 Slc35a1 St3gal1 Nanp St6gal1 Glb1 St6gal2 Nans St8sia2 St8sia3 St8sia1 Ctsa Gne Rbx1 Vcp Hnrnpc Hnrnpk Cops5 Hbs1l Cul3 B3gnt3 Suz12 Rbbp7 Tfam Spta1 Sptb Sptbn1 Sptbn2 Sptan1 Sptbn5 Sptbn4 App Nagk Traf6 Gnpnat1 Amdhd2 Ikbkg Uap1 Gfpt1 Gfpt2 Map3k7 Pgm3 Ube2n Renbp Nfkb2 Hadh Traf2 Fbxw11 Rela Tnip2 Nod2 Nod1 Ripk2 Nfkbia Usp14 Usp18 Tab1 Cetn2 Furin Ltbp1 Bmp4 Fbn1 Rab11b Rab11a Rab31 Rab35 Rab38 Rab1b Trappc2l Rab5a Rab4a Trappc10 Rab33b Rab33a Rab3a Chm Rab7a Rab7b Rab27a Rab39a Rab27b Trappc6b Trappc6a Trappc9 Trappc5 Trappc4 Trappc3 F7 F9 Trappc2 Trappc1 Gas6 Rab6b Rab6a Ceacam1 Rab5c Ahsg Rab5b Spp2 F10 Rab21 Chml Rab9a Rab9b Rab1A Rab10 Rab13 Rab12 Rab14 Rab18 Rab8b Rab8a Qsox1 Serpina10 Rhoa Gria1 Serpind1 Arrb2 Arrb1 Tgfbr1 Lhb Cga Pros1 Serpinc1 Cd109 Thbs1 Igf2 Igf1 Pcna Atp6ap2 Ctsd Ace Mme Ctsg Gzmf Agt Ren1 Ace2 Enpep Ctsz Cma1 Ces1d Cpb1 Cpb2 Cpa3 Scg3 Psme2 Psme1 Psmb9 Proc Psmb10 Psmb8 Proz Aplp2 Mmrn1 Chgb ENSRNOG00000067174 Pdia6 Ccn1 Amelx Pappa Lgals1 Csf1 Scg2 Apoa5 Meltf Mxra8 Fam20a LOC120093819 Fam20c Klk6 Eif2b3 Fuca2 Eif2b2 Stc2 Eif2s3 Wfs1 Eif2b5 Apol7al1 Eif2b4 Hrc Pcsk9 Eif2s2 Ngfg Eif2b1 Ambn Eif2s1 Mepe Cp Pappa2 Apol2 Enam Bmp15 Bpifb2 Apol7bl1 Ano8 Igfbp7 Igfbp6 Igfals Mfge8 Matn3 ENSRNOG00000066972 Rcn1 Vgf Vwa1 Fstl1 Fstl3 Chrdl1 Prss23 Tmem132a Afp Pnpla2 Mbtps1 Igfbp2 Nup93 Igfbp5 Nup50 Igfbp4 Golm1 Igfbp1 Amtn Nup35 Mgat4a Nup54 Nucb1 Nup98 Sparcl1 Msln Cst3 Itih2 Nup58 Apol9a Klk13 Nup37 Pom121 Nup205 Nup107 Sec13 Nup188 Tpr Ctr9 Paf1 Nup160 Rae1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 Aaas Ranbp2 Nup214 Tpst1 Nup133 Nup210 Tpst2 Nup155 Nup153 Shmt2 Alb Mrtfa Apoa1 Apoa2 Sar1b Gps1 Apoe P4hb Apob Cops4 Cops2 Ndufs3 Rnf20 Cct6a Senp1 C3 Cct7 Fshb F2 Penk Grp Bst1 Vnn1 Pccb Nadk2 Gcg Cd55 Folr2 Gh1 Adrb2 Senp5 Senp5l1 Sumo2 Senp2 Ffar1 Kng1 Bcl10 Bche Ero1b Mboat4 Ffar4 Ghrl Inha Pla2g7 Slc30a5 Slc30a8 Pcsk1 Lep Inhba Inhbb Gip Inhbc Inhbe Nr1i2 Smc6 Smc5 Smc3 Pias3 Ddx17 Sp140 Pias1 Pias2 Nsmce4a Casp8ap2 Hic1 Eid3 Uhrf2 Nr3c2 Nr3c1 Nsmce1 Nsmce2 Xpc Zfp131 Sp3 Vdr Stag2 Stag1 Dnmt1 L3mbtl2 Daxx Safb Mageb10 Sp100 Ing2 Ppara Top2b Top2a Top1 Trim28 Trim27 Pcgf2 Thrb Thra Mbd1 Satb2 Satb1 Park7 Smc1a Nr5a1 Tshb Nfe2l2 Taf9b Taf10 Mdh2 Ddb1 Cul4a Cul4b Mat2b Qtgal Adamts1 Adamts3 Adamts2 Adamts9 Adamts8 Adamts7 Adamts6 Pofut2 Thsd1 Thbs2 Pofut3 Pofut4 Thsd4 Cfp Spon2 Icmt Spon1 Sspo B3glct B3gnt9 B3gnt8 Fn1 B3gnt6 B3gnt5 Galnt1 Galnt2 Rce1 Galnt5 ENSRNOG00000067432 Galnt7 Galnt6 Galnt10 Galnt17 Galnt18 Galnt15 Galnt16 Galnt13 Galnt14 Galnt11 Galnt12 Gcnt7 Gcnt4 Gcnt3 Chst4 Sema5a Sema5b Gcnt1 C1galt1 C1galt1c1 Galntl6 Mmrn2 Galntl5 Adamts13 Adamts14 Adamts15 Adamts16 Adamts17 Adamts18 Tgfa Adamts19 Fgf23 Adamts10 Sbspon Areg Kbtbd7 A4gnt Adamts12 Thsd7a Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Galnt9 Adamts20 Thsd7b Il6 Fga Fgg Mt-atp6 Atp5f1c Atp5pd Atp5pf Atp5mg Atp5f1b Atp5f1a Atp5po Mt-atp8 Cdc25a Rpa1 Slc35c1 Eif4ebp1 Rraga Rps6 Eif4e Apeh Blm Pias4 Slc25a5 Ube2i Ube2v2 Bard1 Prkdc Clspn Xrcc4 Bap1 Tp53bp1 Brcc3 Herc2 Rnf168 Sumo1 ABRAXAS1 Sumo3 Rad52 Babam1 Babam2 Ubxn1 Brca1 Uimc1 Riox2 Mitf Jmjd6 Rps27 Dync1h1 Cdca8 Incenp Dync1i2 Dync1i1 Glud1 Acadsb Rangap1 Arg2 Dync1li2 Dync1li1 Dynll1 Dynll2 Cop1 Mdm4 Hsd17b10 Acat1 Birc5 Aldh18a1 Acad8 Men1 Tnks2 Axin1 Axin2 Cdc73 Rnf146 Ctbp1 Tnks Usp34 Smurf2 Leo1 Apc Nlrp3 Txn Rig1 Ikbke Cyld B3gnt7 B3gnt2 Idh2 B4galt4 B4galt5 B4galt6 B4gat1 B4galt2 B4galt3 Mief1 Mtrf1l Trip4 Eif5 Mt-cyb Pelo Gfm1 Gfm2 Srp68 Mrrf Srp9 Mrps9 Mrps2 Mrps7 Mrps5 Mt-nd4l Tcf25 Srp54 Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Nrip1 Mrpl45 Mrpl46 Mrpl48 Mtrf1 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Pdk1 Mrps27 Nr1h3 Malsu1 Nr1h2 Mrpl51 Pdhb Mrpl32 Mrpl33 Oxa1l Rxra Mrpl34 Mrpl35 Mrpl36 Sphk1 Mrpl37 Pgr Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 Srp14 ENSRNOG00000068816 Eral1 Srp19 Mrpl30 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Rara Mrpl16 Mrpl17 Mrpl18 Mmp2 Ascc3 Ascc2 Mrpl19 Eif5b Nemf Zfp598 Gadd45gip1 Mt-co3 Dld Mt-co2 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Klhdc10 Ptcd3 Yy1 Mt-co1 Mt-nd5 Dlat Mt-nd4 Nr5a2 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 Ins1 Lman1 Scfd1 Actr1a Lman2 Ins2 Ggcx Sec22a Bglap Dctn1 Tfg Dctn2 Cog1 Cog2 Dctn4 Cog3 Cog4 Arfgap3 Preb Arfgap2 Cog5 Arfgap1 Cog6 Cog7 Cog8 Napa Nsf Napb Ank1 Napg Sec23a Tmem115 Kdelr2 Kdelr3 Sec23ip Sec16b Sec16a Lman2l Copa Bet1l Cnih1 Gorasp1 Cnih3 Cnih2 Kdelr1 Arf4 Ctsc Arf3 Arf1 Ppp6r3 Mia2 Mia3 Copb2 Tmed10 Tmed9 Copb1 Cope Golgb1 Col7a1 Ppp6c Sec31b Sec31a F8 Stx17 Gosr1 Gosr2 Lman1l Tbc1d20 Copz2 Csnk1d Serpina1 Copz1 Arf5 Golga2 Uso1 Actr10 Sec24d Sec24c Sec24b Sec24a Mcfd2 Stx5 Ykt6 Gbf1 Tmed2 Tmed3 Copg1 Copg2 Folr1 Tmed7 Ankrd28 Cd59 Arcn1 Bet1 AC132020.1 Ogdh Dlst Kgd4 Hsp90b1 Socs5 Chst10 Fkrp Slc35a4 Rxylt1 Crppa Dag1 Large1 Large2 Fktn Pomgnt1 Actg1 Rabggta Rabggtb Socs3 Cox5a Cox5b Ech1 Ube2d3 Ube2d2 Ide Hspd1 Acot1 Acot2 Pex2 Acot5 Acot3 Ldhd Usp9x Pex5 Pex14 Pex13 Pex12 Pex10 Kat2a Hdac2 Me2 Hdac4 Alpi Nr1h4 C4b Rab36 C4 Cops3 Cops6 Cops8 Gcsh Lipt1 Lipt2 Nfu1 Ndufab1 Fdx1 Dbt Lias Cops7a Cops7b Tnc Dmp1 Vcan Akp3 Alpp Alpg Galnt3 Rab43 Ttgn1 Ppa1 Ppa2 Dph5 Dph6 Eef2 H2ac25 Prmt3 Rps2 Calr Arsa Sts Arsl Arsk Arsj Arsi Arsg Sumf1 Arsb Sumf2 Cdh2 Hspa9 Sec11c Sec11a Prkcsh Rab4b Afg3l2 Cand1 Pomt1 Pheta2 Pomt2 Birc2 Pmpca Megf11 Canx Spcs3 Spcs1 Spcs2 Pigs Pigu Pigt Gpaa1 Pigk Plaur Pgap1 Hcfc1 Tada3 Mcrs1 Ogt Traf3 Spg7 Srd5a3 Twnk Pign Pigq Pigp Pigw Ssbp1 Pigv Pigx Pigc Pigb Dpm2 Piga Pigm Pigl Pigg Pigf Dpp4 Gpr119 Pigh Gmppa Pmm2 Prkn Mpi Pmm1 Ripk1 Nploc4 Ube2l3 Sdc2 Gpihbp1 Gpc3 Mgat5b B3galnt2 Pomk Pomgnt2 Adam10 ENSRNOG00000069479 Adamts5 Adamts4 Plg Spp1 Uba2 Rwdd2b Sae1 Timp1 Mmp1b Eef1d Eef1b2 Eef1g Eef1a1 Rps14 Rps15 Rps16 Rps17 Rps15a Rps18 Rps19 Pabpc1 Rpsa Rps10 Rps11 Rps13 Rps4x-ps13 Rps3a Rps27l Rps9 Rps7 Rps8 Rps5 Eif4h Rps26-ps13 Eif3m Eif3j Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Rps3 Rps25 Rps4x Rps26 Rps28 Rps29 Rps20 Rps21 Rps23 Rps24 Eif1ax Eif4a2 Eif4a1 Fau Stambpl1 Nfrkb Myc Foxk2 Foxk1 Vdac2 Yod1 Vdac3 Vdac1 Tfpt Becn1 Tomm70 Otud7a Actr5 Otud7b Actr8 Josd2 Josd1 Rnf123 Rnf128 Stam Snx3 Ar Hif1a Zranb1 Cftr Siah2 Keap1 Ino80 Wdr48 Ddb2 Ufd1 Foxo4 Uchl3 Abraxas2 Uchl5 Ifih1 Fkbp8 Ino80e Ino80d Rnf181 Ino80c Shprh Ino80b Rad18 Il33 Wdr20 Rnf152 Rnf40 Mbd5 Mbd6 Rnf144a Uchl1 Hltf Wac Nedd8 Atxn3 Atxn7 Suds3 Usp2 Mul1 Usp3 Usp4 Kdm1b Usp5 Usp7 Usp8 Hgs Ruvbl1 Stambp Rad23a Rad23b Tomm20 Bdh1 Tada2b Smad1 Oxct1 Smad2 Hmgcs2 Smad3 Smad4 Smad7 Otub1 Usp44 Usp42 Usp48 Usp47 Stam2 Usp30 Otub2 Vcpip1 Usp33 Usp37 Mysm1 Tnip3 Tnip1 Senp8 Otud3 Usp22 Uqcrq Usp21 Usp20 Usp26 Ndufv1 Usp25 Ndufv3 Usp24 Usp29 Usp28 Ccp110 Asxl1 Asxl2 Pten Usp12 Ndufs1 Usp11 Usp10 Ndufa13 Usp16 Usp15 Usp13 Usp19 Eci1 Uqcrc2 Etfb Rab2a Cct3 Cct2 Exoc3 Exoc4 Exoc5 Exoc6 Exoc1 Exoc2 Exoc7 Exoc8 Tcp1 Cct8 Cct5 Cct4 Tfap2c Tdg Rpl4 Rpl5 Rpl3 Rgs9 Rpl35 Rpl36 Rpl37 Rpl38 Rpl39 Camkmt Rpl8 Rpl9 Rpl6 Rpl7 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rpl12-ps1 Rpl22 Rpl23 LOC120097744 Ubxn7 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 LOC100910714 Dcaf13 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME%R-RNO-1855167.1 Synthesis of pyrophosphates in the cytosol Ippk Itpk1 Nudt4 Ip6k1 Nudt3 Ip6k3 Ppip5k1 Ppip5k2 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223651 Amine ligand-binding receptors Drd3 Drd4 Drd5 Taar6 Adra2b Taar9 Taar3 Taar2 Adra2a Taar5 Taar1 Adra2c Gpr143 Adrb2 Htr4 Adrb1 Adra1b Adrb3 Adra1a Htr6 Adra1d Htr7 Taar8c Htr2a Htr2c Htr2b Htr5a Htr1d Htr1f Chrm1 Hrh1 Chrm3 Chrm2 Htr1b Chrm5 Htr1a Hrh4 Chrm4 Hrh2 Hrh3 Drd2 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 96%10223693 Glutamate binding, activation of AMPA receptors and synaptic plasticity Tspan7 Grip1 Prkcg Prkca Nsf Ap2m1 Myo6 Cacng8 Cacng3 Grip2 Cacng4 Prkcb Epb41l1 Cacng2 Ap2s1 Gria4 Gria3 Camk2g Camk2d Ap2a2 Gria2 Ap2a1 Camk2b Ap2b1 Pick1 Dlg1 Gria1 Dlg4 Camk2a Akap5 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%10222227 SOS-mediated signalling Grb2 Irs2 Sos1 Irs1 MAPK1 (ERK2) ACTIVATION%REACTOME%R-RNO-112411.1 MAPK1 (ERK2) activation Mapk1 Jak2 Tyk2 Ptpn11 Il6 Map2k2 Il6st Il6r PEROXISOMAL PROTEIN IMPORT%REACTOME%R-RNO-9033241.1 Peroxisomal protein import Phyh Amacr Eci2 Mpv17 Gstk1 Hacl1 Pex26 Mlycd Scp2 Gnpat Crat Acox1 Acox2 Ech1 Ehhadh Acox3 Ube2d3 Ube2d2 Pipox Acaa1b Tysnd1 Hsd17b4 Lonp2 Hao1 Hao2 Pecr Dao Dhrs4 Slc27a2 Ide Decr2 Crot Nudt19 Rps27a Acot1 Acot2 Pex2 Pex1 Acot5 Acot3 Acot4 Pex7 Usp9x Acot8 Pex6 Pex5 Cat Uba52 Baat Ddo Ube2d1 Zfand6 Agps Agxt Nudt7 Hmgcl Nos2 Ephx2 Pex14 Pex13 Pex12 Pex10 Ubb Ubc Idh1 RUNX3 REGULATES P14-ARF%REACTOME%R-RNO-8951936.1 RUNX3 regulates p14-ARF Runx3 Cbfb Ccnd1 Hdac4 Ep300 Tgfb1 RELAXIN RECEPTORS%REACTOME%R-RNO-444821.1 Relaxin receptors Rln1 Rxfp3 Rxfp1 Insl3 Rln3 MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 96%10225071 MET activates RAP1 and RAC1 Hgf Grb2 Rap1a Rap1b Dock7 Rac1 Met Crkl Crk Rapgef1 Gab1 SIGNALING BY PDGF%REACTOME%R-RNO-186797.1 Signaling by PDGF Stat6 Grb7 Thbs4 Stat3 Ptpn12 Furin Stat1 Plcg1 Thbs2 Nck1 Plg Spp1 Rasa1 Plat Pdgfa Pdgfb Thbs1 Stat5a Stat5b Bcar1 Pik3ca Col4a1 Nck2 Col4a2 Crkl Pdgfrb Src Pdgfra Rapgef1 Pik3r1 Pik3cb Nras Grb2 Pik3r2 Kras Sos1 Hras Pdgfc Ptpn11 Pdgfd Crk SIGNALING BY ALK%REACTOME%R-RNO-201556.1 Signaling by ALK Ptprz1 Pik3ca Hdac2 Shc1 Stat3 Ptpn6 Alkal2 Plcg1 Alkal1 Ep300 Pik3r1 Pik3cb Jak3 Pik3r2 Irs1 Hdac3 Alk Mdk Hdac1 Ptn SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME DATABASE ID RELEASE 96%10224441 SHC-related events triggered by IGF1R Igf1 Grb2 Shc1 Sos1 Igf1r Igf2 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 96%10225065 Vitamin E transport Ttpa SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 96%10224347 Signaling by NOTCH Aph1b Uba52 Jag2 Dll1 Dll4 Tmed2 Dtx4 Egf Ubb Ubc Ybx1 Egfr Jag1 Prkci Elf3 Notch3 Akt1 Itch Rps27a Adam10 Notch4 Wwp2 Psenen Psen1 Psen2 Ncstn Dtx2 Aph1a Ywhaz TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-RNO-5656169.1 Termination of translesion DNA synthesis Uba52 Usp10 Pole3 Pole2 Ube2l6 Pole4 Rpa1 Rpa2 Polk Trim25 Ubb Rpa3 Ubc Polh Rev1 Poli Pole Rfc5 Pold2 Pold1 Isg15 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pold4 Pclaf Pold3 Usp43 Rps27a Uba7 DISINHIBITION OF SNARE FORMATION%REACTOME%R-RNO-114516.1 Disinhibition of SNARE formation Prkcb Stxbp3 Prkcg Stx4 Prkca CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME%R-RNO-6807047.1 Cholesterol biosynthesis via desmosterol (Bloch pathway) Ebp Msmo1 Sc5d Lbr Nsdhl Dhcr24 Dhcr7 Tm7sf2 Hsd17b7 DNA REPLICATION INITIATION%REACTOME%R-RNO-68952.1 DNA replication initiation Prim2 Prim1 Pole Pole3 Pole2 Pole4 Pola2 Pola1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-RNO-3270619.1 IRF3-mediated induction of type I IFN Sting1 Nlrp4 Dtx4 Tbk1 Irf3 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%10224265 Mitochondrial biogenesis Sirt5 Sirt3 Glud1 Mt-atp6 Atp5mc1 Atp5f1e Atp5f1d Atp5f1c Atp5pb Atp5pd Atp5mc3 Atp5mc2 Atp5pf Cycsl2 Atp5mf Gabpa Atp5me Dmac2l Atp5mg Atp5f1b Atp5f1a Atp5po Atp5mk Mt-atp8 Idh2 Acss2 Cycs Sod2 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-RNO-913709.1 O-linked glycosylation of mucins Qtgal B3gnt9 B3gnt8 B3gnt6 B3gnt5 Galnt1 Galnt2 Galnt5 Galnt7 Galnt6 Galnt10 Galnt17 Galnt18 Galnt15 Galnt16 Galnt13 Galnt14 Galnt11 Galnt12 Gcnt7 Gcnt4 Gcnt3 Chst4 Gcnt1 C1galt1 C1galt1c1 Galntl6 Galntl5 Muc15 Muc13 Muc19 A4gnt Muc5b Muc4 Muc6 Galnt9 St6galnac3 St6galnac2 St3gal4 St3gal2 St3gal3 St3gal1 St6gal1 B3gnt7 B3gnt2 B4galt5 B4galt6 B3gnt3 Galnt3 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%10222295 Glycerophospholipid biosynthesis Plaat5 Agk Ddhd2 Agpat4 Agpat1 Pcyt2 Tafazzin Cept1 Lclat1 Etnk2 Etnk1 Etnppl Chka Gnpat Chkb Selenoi Phospho1 Lpin3 Lpin2 Plb1 Chat Dgat2l6 Dgat2 Dgat1 Pnpla3 Pld1 Stard7 Cds1 Cdipt Pitpnm2 Pitpnm3 Pitpnm1 Hadha Hadhb Agpat2 Alpi Cpne1 Pla2g4f Pla2g2d Cpne3 Pla2g2f Pla2g4c Pla2g2a Pla2g4e Pla2g1b Csnk2a2 Pla2g4d Plbd1 Pla2r1 Csnk2a1 Pla2g12a Mboat7 Pla2g10 Plaat3 Pld2 Pla2g5 Csnk2b Ptdss1 Ptdss2 Pla2g15 Pla2g4b Agpat3 Slc44a3 Slc44a4 Slc44a5 Slc44a1 Slc44a2 Pctp Awat2 Pnpla2 Lpcat4 Lpgat1 Lpcat1 Pla2g3 Crls1 Mfsd2a Pla2g6 Pcyt1b Pcyt1a Abhd3 Pemt Chpt1 Stard10 Gpd1l Abhd4 Osbpl10 Miga2 Miga1 Gpat2 Gpd1 Pgp Mboat1 Mboat2 Pitpnb Gpam Gpd2 Osbpl5 Pld6 Pla1a Mgll Osbpl8 Pla2g4a Cpne6 Cpne7 Liph Lipi Cds2 Acp6 Gpat4 Gpat3 Lpcat3 Lpcat2 Tmem86b Pnpla8 Plaat1 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 96%10224101 ER Quality Control Compartment (ERQC) Rps27a Uba52 Ubb Ubc POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 96%10224517 Postmitotic nuclear pore complex (NPC) reformation Nup133 Nup155 Rangap1 Nup37 Ube2i Rcc1 Pom121 Nup205 Nup107 Sec13 Nup188 Nup160 Ahctf1 Ndc1 Nup85 Nup93 Nup43 Ran Nup35 Sumo1 Nup98 NOD1 2 SIGNALING PATHWAY%REACTOME%R-RNO-168638.1 NOD1 2 Signaling Pathway Ikbkg Casp1 Casp8 Map3k7 Ube2n Mapk14 Birc2 Cyld Itch Mapk12 Tab3 Tab2 Aamp Mapk13 Tab1 Casp2 Nod2 Casp9 Nod1 Mapk11 Map2k6 Traf6 Ripk2 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-RNO-5674499.1 Negative feedback regulation of MAPK pathway Map2k1 Mapk1 Raf1 Braf Mapk3 Map2k2 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 96%10224611 SUMOylation of DNA methylation proteins Ube2i Dnmt1 Sumo1 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-RNO-75953.1 RNA Polymerase II Transcription Initiation Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2f1 Gtf2h3 Cdk7 Gtf2h5 Ercc2 Ercc3 Mnat1 Taf9 Taf9b Taf15 Taf11 Taf10 Taf13 Taf12 Tbp Taf4b Ccnh Taf7l-ps1 Gtf2a1 Gtf2a2 Gtf2b Taf8 Taf7 Taf6 Taf5 Gtf2e1 Polr2c Taf4 Polr2a Taf2 Polr2b Taf1 Polr2g Gtf2e2 Polr2h Polr2e Polr2f Polr2i ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-RNO-418592.1 ADP signalling through P2Y purinoceptor 1 Gna11 Pla2g4a Gna14 P2ry1 Mapk14 Src Gnaq DNA REPAIR%REACTOME DATABASE ID RELEASE 96%10222001 DNA Repair Chd1l Ppie Usp45 Ube2t Gps1 Nploc4 Sprtn Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Mapk8 Polr2i Polr2j Ube2n Gtf2h2 Gtf2h1 Mlh1 Msh6 Msh2 Gtf2h3 Pms2 Gtf2h5 Cops4 Ercc2 Cops2 Ercc3 Ppp5c Cetn2 Tcea1 Terf2 Neil3 Acd Terf1 Mpg Ogg1 Terf2ip Mutyh Tinf2 Pot1 Ccna1 Ccna2 Cops3 Cops6 Pclaf Cops8 Usp43 Rps27a Usp1 Dtl Ercc6 Fancl Fancm Uba52 Fanca Fancb Fancc Fance Fancf Fancg Neil2 Pnkp Neil1 Pole3 Cops7a Pole2 Cops7b Pole4 Rpa1 Rpa2 Uvssa Trim25 Rpa3 Ubb Ubc Faap100 Pole Faap24 Nfrkb Isg15 Faap20 Cdk2 Tfpt Actr5 Yy1 Actr8 Ino80 Wdr48 Ddb2 Ufd1 Alkbh5 Fto Ino80e Ino80d Ino80c Ino80b Rad18 Ube2l6 Usp7 Rnf111 Mad2l2 Rev1 Rev3l Ruvbl1 Poli Rad23a Rad23b Sumo2 Blm Wrn Dna2 Rif1 Ppp4r2 Paxip1 Pias4 Mre11 Ube2i Eme2 Kat5 Eme1 Timeless Nbn Usp10 Gen1 Hus1 Atrip Lig3 Lig4 Sirt6 Rad51c Baz1b Rad51b Chek1 Chek2 Znf830 Ube2v2 Ube2b Rad9a Rad9b Bard1 Top3a Prkdc Palb2 Firrm Tp53 Ppp4c Nhej1 Lig1 Parg Clspn Rad17 Polb Fen1 Kpna2 Parp2 Xrcc6 Parp1 Xrcc3 Rfc5 Apex1 Slx1b Pold2 Adprs Xrcc2 Pold1 Tdp2 H2ab2 Rfc3 Xrcc5 Rfc4 Tdp1 Pcna Xrcc4 Rfc1 Xrcc1 Ccnh Atm Rfc2 Atr H2ac4 Bap1 Pold4 Tp53bp1 Pold3 Actl6a Apbb1 Kdm4b Kdm4a Exo1 Pias3 Mus81 Rmi2 Fignl1 Rmi1 Pias1 Brip1 Brcc3 Abl1 ENSRNOG00000066901 Smarca5 Uba7 Polq Herc2 Rnf168 Sumo1 ABRAXAS1 Polm Sumo3 Xpc Xab2 Rnf8 Dclre1c Rhno1 Slx4 Nsd2 Spidr Rad51 Cdk7 Rad50 Rad52 Eya2 Eya1 Ercc1 H2ac18 Eya4 Ercc4 Babam1 Eya3 Babam2 Topbp1 Rbbp8 Ubxn1 Brca2 Mnat1 Brca1 Rad51ap1 Polk Hist1h2bq Uimc1 Prpf19 Actg1 Poll Rad1 Polh H2aj Hist3h2ba ENSRNOG00000068602 Dclre1a Isy1 Dclre1b Mbd4 Fanci Smug1 Nthl1 Fancd2 Haus3 Tdg Ung Fan1 H2az2 H2bc4 Hist1h4m H2bc1 Hist1h2ai Rchy1 Mcrs1 Aqr Rbx1 Vcp Cops5 Xpa Ddb1 Cul4a Cul4b WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 96%10224619 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cltb Cltc Fzd2 Fzd5 Wnt5a Ap2s1 Ap2a2 Ap2a1 Ap2b1 Ror1 Ap2m1 Ror2 Clta RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-RNO-110314.1 Recognition of DNA damage by PCNA-containing replication complex Wdr48 Uba52 Rad18 Pole3 Pole2 Pole4 Ube2b Rpa1 Rpa2 Ubb Rpa3 Ubc Pole Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rbx1 Rfc2 Pold4 Pold3 Rps27a Usp1 Dtl Ddb1 Cul4a Cul4b CASP8 ACTIVITY IS INHIBITED%REACTOME%R-RNO-5218900.1 CASP8 activity is inhibited Ripk1 Tnfsf10 Casp8 Fas Fadd Faslg Traf2 Tradd Cflar ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224081 Antigen processing: Ubiquitination & Proteasome degradation Mib2 Ube2d3 Ube2d2 Prkn Stub1 Ube2l3 Kbtbd7 Smurf2 Ube2n Fbxw11 Cbll1 Ube2j2 Psma4 Psma3 Ube2s Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Btrc Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cul1 Cdc16 Rnf123 Siah2 Keap1 Lrr1 Nedd4 Rnf220 Fbxl21 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb Sh3rf1 Trim11 Ube2l6 Mex3c Cdc34 Dcaf1 Rnf126 Ubac1 Lnpep Atg7 Rnf114 Rnf115 Rnf111 Siah1 Dzip3 Mkrn1 Ube2g2 Ube2g1 Rnf138 Rnf130 Kbtbd8 Fbxw4 Fbxw5 Fbxw7 Gan Fbxw8 Fbxw9 Anapc13 Det1 Fbxw2 Klhl5 Rbck1 Arih2 Rlim Klhl3 Klhl2 Ube4a Spsb2 Trim9 Spsb1 Trip12 Wwp1 Spsb4 Lrsam1 Eloc Huwe1 Elob Ube2j1 Kctd7 Ube2u Kctd6 Ube2w Ube2m Ube2k Rnf182 Ube2o Ltn1 Ube2v2 Ube2b Mgrn1 Ube2f Ube2a Fbxo10 Fbxo11 Fbxo15 Fbxo17 Lmo7 Rnf41 Mylip Ube3d Ube3c Lrrc41 Klhl13 Klhl11 Ube2z Ube3b Ube3a Traip Fbxo21 Fbxo22 Ubox5 Ubr1 Rnf19a Ubr2 Glmn Ubr4 Fbxo27 Uba5 Uba6 Trim69 Uba7 Fbxw17 Herc2 Socs1 Trim71 Klhl25 Rnf19b Ube2e3 Ube2e2 Klhl21 Btbd6 Hace1 Klhl22 Klhl20 Fbxo30 Fbxo31 Fbxo32 Fbxl3 Fbxl4 Fbxl5 Fbxl7 Lonrf1 Zbtb16 Uba1 Uba3 Cul2 Tpp2 Cul5 Cul7 Fbxo41 Fbxo44 Hectd2 Hectd3 Thop1 Znrf2 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Ufl1 Fbxo40 Npepps Ube2q1 Btbd1 Pja2 Pja1 Arel1 Trim63 Rnf144b Fbxo2 Asb12 Asb14 Itch Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc3 Ube2r2 Herc1 Fbxo4 Fbxo6 Rnf4 Fbxo7 Herc6 Fbxo9 Trim21 Vhl Rnf34 Fbxl15 Fbxl16 Trim39 Fbxl19 Trim37 Rbbp6 Trim36 Trim32 Trim41 Unkl Asb9 Asb7 Asb6 Asb5 Rnf25 Asb4 Rchy1 Asb1 Lnx1 Rbx1 Socs3 Smurf1 Cul3 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 96%10224623 PINK1-PRKN Mediated Mitophagy Map1lc3b Ube2n Uba52 Ube2d3 Ube2d2 Ubb Ubc Mfn1 Mfn2 Tomm22 Tomm20 Atg5 Tbk1 Atg12 Vdac2 Atg9a Sqstm1 Vdac3 Vdac1 Tomm40 Prkn Optn Tomm70 Rps27a Mterf3 Map1lc3a Pink1 Ube2l3 Tomm7 B CELL ACTIVATION%REACTOME%R-RNO-983705.1 B Cell Activation Rasgrp1 Calm3 Itpr3 Itpr2 Itpr1 Lyn Nras Grb2 Kras Sos1 Hras Ikbkb Ikbkg Dapp1 Cd22 Blnk Cd79a Cd79b Nfkb1 Fbxw11 Rela Ppp3ca Ppp3cb Trpc1 Nfatc1 Stim1 Nfatc3 Malt1 Nfatc2 Bcl10 Ppp3r1 Nfkbie Rel Nfkbib Prkcb Nfkbia Btk Chuk Ptpn6 Psma4 Psma3 Psma6 Pik3r1 Psma5 Psma2 Psma1 Cd19 Rps27a Psmd12 Psmd11 Vav1 Pik3cd Psmd14 Psmd13 Sh3kbp1 ENSRNOG00000069193 AABR07065813.1 Skp1 ENSRNOG00000062915 Igll1 Psmb5 ENSRNOG00000065191 Psmb4 Ighl12 Psmb7 ENSRNOG00000062682 Psmb6 ENSRNOG00000070812 ENSRNOG00000070415 Psmb1 ENSRNOG00000070810 Psmb3 ENSRNOG00000066926 Psmb2 ENSRNOG00000066406 Uba52 ENSRNOG00000067897 ENSRNOG00000062685 ENSRNOG00000070192 Pik3ap1 Syk Btrc Iglc1 Nck1 ENSRNOG00000070159 Psma7 ENSRNOG00000071049 AABR07034736.1 ENSRNOG00000065564 Psmc5 Psmc2 ENSRNOG00000066971 Psmc1 ENSRNOG00000063341 Psmc4 ENSRNOG00000065283 Psmc3 ENSRNOG00000062976 ENSRNOG00000063549 ENSRNOG00000063148 Igkvl13 AABR07065812.2 ENSRNOG00000063707 Plcg2 Ubb ENSRNOG00000067679 ENSRNOG00000070832 Ubc ENSRNOG00000064041 ENSRNOG00000064481 Psmb6l1 ENSRNOG00000065690 ENSRNOG00000064085 ENSRNOG00000066904 Psmd7 ENSRNOG00000063713 ENSRNOG00000062820 Psmd6 ENSRNOG00000064886 Psmd8 Fkbp1a ENSRNOG00000064490 ENSRNOG00000066072 Psmd2 AABR07065781.1 ENSRNOG00000069901 Psmd1 ENSRNOG00000067603 Adrm1 Cul1 ENSRNOG00000066431 ENSRNOG00000068499 ENSRNOG00000069940 ENSRNOG00000067643 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 96%10224385 alpha-linolenic acid (ALA) metabolism Fads1 Elovl2 Elovl3 Abcd1 Elovl5 Elovl1 Scp2 Acox1 Acsl1 Acaa1b Hsd17b4 Acot8 Fads2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-RNO-212165.1 Epigenetic regulation of gene expression Suz12 Eed Gsk3b Rbbp4 Znf431l2 Rbbp7 Tasor Men1 ENSRNOG00000065205 Znf624l Phf19 Zfp867 Mtf2 Epop Cdk5 Rex2l4 Zfp52 Zfp950l5 Mybbp1a Znf354a Dnmt3a Polr2h LOC102546572 Polr2e Polr2f Paxip1 Ddx21 Baz1b Polr1c Znf382 Suv39h1 Kat2a Rrp8 Ezhip H2ab2 Zfp317 H2ac4 Sirt1 Setd1b Setd1a Morc2 Abl1 ENSRNOG00000066901 Smarca5 Sf3b1 Ncoa2 Kmt2d Crebbp Dnmt1 Dek Kmt2a Kmt2b Kmt2c H2ac18 Zfp324 LOC120095871 Setdb1 Trim28 Zfp719 Actg1 Hist1h2bq Wdr5 Ash2l ENSRNOG00000070049 Mphosph8 Aebp2 Ezh1 H2aj Atf7ip Zfp758 Polr1b Tbp H3-3b Polr1a Polr1f Hist3h2ba Polr1g Ep300 Polr1e Polr1h ENSRNOG00000068602 Med23 Taf1d Med24 Med20 Mbd2 Zfp964 Tasp1 Taf1a Akap8l Taf1c Tdg Cxxc1 Taf1b Kat8 H2bc18 Med27 Med12 Kat2b Med1 H2az2 Yeats2 Rbbp5 Med13 H2bc4 Ercc6 Med14 Hist1h4m Wdr82 Jarid2 H2bc1 Rxra Med10 Ccnc Med4 Hist1h2ai Pparg Med6 Kat14 Phf20 Mbip Hcfc1 Tbl1x Med16 Med17 Hcfc2 Dr1 Cbx5 Kansl3 Kansl1 Kansl2 Phf20l1 Ajuba Bod1l1 Pagr1 Tada3 Med30 Pphln1 Tada2a Med31 Myo1c Ppargc1a Ppargc1b Mcrs1 Zzz3 Hdac3 Sgf29 Psip1 Ogt Tbl1xr1 Rb1 Zfp808l3 Ncor2 Gps2 Ncoa3 Ezh2 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-RNO-198693.1 AKT phosphorylates targets in the nucleus Foxo1 Creb1 Foxo4 Rps6kb2 Foxo6 Akt3 Akt2 Akt1 Nr4a1 Foxo3 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-RNO-418038.1 Nucleotide-like (purinergic) receptors P2ry4 P2ry1 Lpar6 Lpar4 Adora2b Gpr17 Adora2a Adora1 Adora3 P2ry10 P2ry13 P2ry12 P2ry14 P2ry2 P2ry6 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-RNO-174414.1 Processive synthesis on the C-strand of the telomere Acd Terf1 Fen1 Terf2ip Pold2 Pold1 Tinf2 Pot1 Pcna Pold4 Pold3 Rpa1 Blm Rpa2 Wrn Rpa3 Terf2 Lig1 Dna2 BASE EXCISION REPAIR%REACTOME%R-RNO-73884.1 Base Excision Repair H2ac18 Hist1h2bq Terf2 Neil3 Acd Terf1 Mpg Ogg1 H2aj Terf2ip Mutyh Tinf2 Pot1 Hist3h2ba ENSRNOG00000068602 Mbd4 Smug1 Nthl1 Tdg Ung H2az2 H2bc4 Hist1h4m H2bc1 Hist1h2ai Lig3 Neil2 Pnkp Neil1 Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Lig1 Parg Polb Fen1 Pole Parp2 Parp1 Rfc5 Pold2 Apex1 Pold1 Adprs H2ab2 Rfc3 Rfc4 Pcna Rfc1 Xrcc1 Rfc2 H2ac4 Pold4 Pold3 ENSRNOG00000066901 AXON GUIDANCE%REACTOME%R-RNO-422475.1 Axon guidance Erbb2 Gsk3b Frs2 Prkcq Ranbp9 Tln1 Rasa1 Fgfr1 Creb1 Ret Spta1 Col4a1 Ptpra Col4a2 Ncam1 Sptb Sptbn1 Sptbn2 Ptk2 Sema5a Mapk3 Sptan1 Sptbn5 Artn Ptprc Rps6ka5 Gfra1 Nras Sptbn4 Grb2 Gfra2 Gfra4 Fyn Kras Sos1 Hras Sdc2 Mapk7 Arpc3 Arpc2 Map2k2 Sema4d Plxnb1 Map2k1 Arpc5 Arpc4 Dnm2 Nrp1 Efna1 Egfr Efna2 Epha1 Shc3 Epha3 Hsp90ab1 Epha4 Pspn Epha5 Epha6 Epha7 Epha10 Efna4 Dcc Gdnf Efna5 Dpysl2 Arpc1b Kif4b Actr2 Ap2s1 Arpc1a Kif4a Actr3 Rdx Msn L1cam Dnm3 Ap2a2 Ap2a1 Ap2b1 Nrtn Arhgef28 Numb Sh3gl2 Ezr Itgav Rhoc Cd72 Plxnb3 Sema6d Crmp1 Plxna4 Myo9b Plxna3 Shank3 Itga2b Plxna2 Rras Tyrobp Met Plcg1 Sema4a Dpysl3 Dpysl4 Dpysl5 Plxnc1 Arhgap35 Sema3a Sema7a Fes Trem2 Sema3e Itgb1 Plxna1 Grb10 Itgb3 Sdcbp Efnb1 Arhgef7 Rock2 Efnb2 Rock1 Efnb3 Plxnd1 Ephb1 Dscaml1 Ephb2 Ntn4 Ephb3 Dscam Ephb4 Ephb6 Unc5a Nck2 Rac1 Pak3 Rnd1 Git1 Hsp90aa1 Sh3kbp1 Limk1 Dok1 Nck1 Actb Itga9 Mmp2 Mmp9 Lypla2 Gap43 Mapk1 Grb7 Prkaca Prkacb Pdlim7 Dok4 Dok5 Prkca Dok6 Cdk5r1 Ank1 Pak1 Pak2 Cdk5 Lyn Nfasc Yes1 Src Rlc-a Rhoa Ngef Grin1 Grin2b Epha2 Reln Dab1 Rhob Rap1gap Dok2 Csnk2a2 Csnk2a1 Actg1 Csnk2b Pik3ca Tiam1 Shc1 Gab2 Farp2 Pip5k1c Pik3r1 Arhgef11 Pik3cb Arhgef12 Vav3 Pik3r2 Pik3r3 Vav2 Pik3cd Itsn1 Ptpn11 Psenen Psen1 Psen2 Kalrn Ncstn Aph1a Gab1 Aph1b Irs2 St8sia4 Vldlr Trio St8sia2 Ap2m1 Clta Cltc Dnm1 Cdc42 CHROMATIN MODIFYING ENZYMES%REACTOME%R-RNO-3247509.1 Chromatin modifying enzymes Suz12 Eed Wdr77 Rbbp4 Rbbp7 Suds3 Brpf3 Kdm1b Kdm5b Coprs H2ac25 Prmt7 Atf2 Dnmt3a Prmt3 Rps2 Brwd1 Nfkb2 Nfkb1 Rela Suv39h1 Hdac2 Arid1a Arid1b Hdac10 Kmt5a Hdac8 H2ac4 Actl6a Actl6b Kdm4b Smarce1 Kdm4a Setd1b Setd1a ENSRNOG00000066901 Ccnd1 Padi2 Ncoa2 Padi3 Padi4 Nsd2 Padi1 Kmt2d Kat7 Padi6 Ehmt1 Kdm6b Kmt2a Kdm7a Kmt2b Kmt2c Phf2 H2ac18 Phf8 Ing4 Ing5 Setdb2 Setdb1 Brd1 Pax3 Dot1l Setd3 Nsd3 Pbrm1 Setd2 Prmt6 Setd7 Hist1h2bq Setd6 Prmt1 Nsd1 Smarcb1 Ash1l Riox2 Hdac1 Suv39h2 Wdr5 Smyd2 Rcor1 Ash2l Mecom Smyd3 Brms1 Aebp2 Kmt5b Hat1 Kdm4c Atf7ip Jade1 Jade2 Smarca2 Jade3 Smarca4 Brpf1 Kat6b Kat6a Prdm16 Hist3h2ba Sap30l Kdm4d Meaf6 ENSRNOG00000068602 Arid5b Chd3 Uty Chd4 Smarcd1 Msl2 Msl3 Smarcd3 Kdm5c Msl1 Smarcd2 Kdm5a Kat8 Kdm6a Mta1 H2bc18 Arid4b Mta2 Arid4a Mta3 Jmjd6 Mbd3 Kdm2b Rbbp5 Rest H2bc4 Kdm1a Kmt5c Hist1h4m Gatad2a H2bc1 Kdm3b Gatad2b Kdm3a Prdm9 Smarcc1 Hist1h2ai Hmg20b Phf20 Hcfc1 Tbl1x Sap18 Kansl3 Kansl1 Kansl2 Mcrs1 Hdac3 Ogt Tbl1xr1 Prmt5 Ncor2 Carm1 Gps2 Cdk4 Ezh2 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-RNO-8941858.1 Regulation of RUNX3 expression and activity Runx3 Psmb6 Cbfb Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Src Ep300 Psma5 Psma2 Smurf1 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Smurf2 Tgfb1 Psmb7 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%10223735 Nitric oxide stimulates guanylate cyclase Pde5a Pde11a Itpr1 Pde10a Prkg1 Pde1b Pde9a Pde1a Nos3 Nos2 Irag1 Pde2a Nos1 Prkg2 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 96%10225295 Transcriptional regulation of granulopoiesis Cebpa Cdk4 Cdk2 Rara Rxra HEDGEHOG 'OFF' STATE%REACTOME%R-RNO-5610787.1 Hedgehog 'off' state Adcy5 Adcy6 Gsk3b Adcy9 Prkaca Prkacb Prkar1a Prkar1b Rpgrip1l Tulp3 Adcy10 Ift140 Kif3a Fuz Mks1 Ift52 Ttc21b Ift57 Ift122 Ofd1 Intu Prkar2a Wdr35 Prkar2b Dync2h1 Psma4 Ift172 Wdr19 Psma3 Psma6 Psma5 Psma2 Psma1 Itch Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Btrc Psma7 Csnk1a1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Gpr161 Psmd8 Gli1 Psmd2 Gli3 Gli2 Psmd1 Adrm1 Kif7 Rbx1 Cul1 Smo Ptch1 Sufu Adcy3 Numb Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-RNO-168188.1 Toll Like Receptor TLR6:TLR2 Cascade Ppp2cb Ppp2ca Ppp2r5d Creb1 Ppp2r1b Ppp2r1a Mapk3 Rps6ka5 Rps27a Nkiras1 App Mapk9 Atf2 Ikbkb Atf1 Skp1 Mapk7 Nkiras2 Mapk8 Traf6 Peli1 Ikbkg Map3k8 Map3k7 Ube2n Lrrc14 Uba52 Nfkb2 Nfkb1 Traf2 Ecsit Fbxw11 Fos Btrc Vrk3 Alpk1 Rela Rps6ka3 Map3k1 Peli2 Rps6ka1 Peli3 Tifa Rps6ka2 Tnip2 Nod2 Nod1 S100b Map2k7 Map2k6 Ubb Dusp3 Hmgb1-ps34 Ubc Dusp4 Ripk2 N4bp1 Dusp7 Dusp6 Casp8 Nfkbib Mapkapk3 Mapk14 Jun Mapkapk2 Irak2 Irak1 Ager Cul1 Nfkbia Hmgb1l2 Hmgb1l1 Tirap Nlrx1 Map2k3 Mapk1 Usp14 Tab3 Tab2 Usp18 Tab1 Nlrc5 Chuk Mapk10 Mapk11 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-RNO-170660.1 Adenylate cyclase activating pathway Adcy5 Adcy6 Adcy9 Adcy3 Adcy4 Gnal Adcy1 Adcy2 Adcy7 Adcy8 MITOCHONDRIAL TRANSLATION%REACTOME%R-RNO-5368287.1 Mitochondrial translation Mief1 Mtrf1l Mt-cyb Gfm1 Gfm2 Mrrf Mrps9 Mrps2 Mt-atp6 Mrps7 Mrps5 Mt-nd4l Dap3 Mrpl54 Mrpl55 Mrpl58 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl48 Mt-atp8 Mtrf1 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Malsu1 Mrpl51 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrps10 Mrpl39 Mrps12 Chchd1 Mrps15 Mrpl40 Ndufab1 Mrpl41 Mrpl42 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 ENSRNOG00000068816 Eral1 Mrpl30 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 AC132020.1 Mrpl15 Mrpl16 Mrpl17 Kgd4 Mrpl18 Mrpl19 Gadd45gip1 Mt-co3 Mt-co2 Mrpl20 Mrpl3 Mrpl4 Mrpl1 Mrpl2 Mrpl9 Mrps18c Mrps18b Mrps18a Ptcd3 Mt-co1 Mt-nd5 Mt-nd4 Mt-nd6 Mt-nd1 Mt-nd3 Mt-nd2 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%10222119 Phase I - Functionalization of compounds Cyp39a1 Cyp2s1 Ncoa2 Cyp8b1 Cyp7b1 Nr1h4 Cyp2w1 Cyp46a1 Cyp27a1 Cyp2c24 Cyp7a1 Smox Aldh1a1 Cyp2u1 Pomc Arnt2 Aldh2 Arnt Ahrr Ahr Aldh1b1 Cyp11a1 Fdx2 Fdxr Adh6 Adh5 Cyp26b1 Cmbl Ephx1 Aldh3a1 Fmo1 Aadac Cbr3 Aoc3 Nqo2 Fmo3 Fmo2 Cyp11b1 Cyp11b2 Cyp19a1 Rxra Acss1 Cyp26a1 Mtarc2 Bphl Cyp24a1 Cyp3a9 Cyp27b1 Cyp1b1 Adh4 Fdx1 Cyp3a18 Adh1 Cyp4v2 Cyp2c66 Cyp2e1 Cyp2c11 Cyp1a1 Tbxas1 Cyp3a1 Cyp1a2 Cyp2d4 Ptgis Cyp3a62 Cyp3a2 Ptgs1 Ces2h Maoa Hsp90ab1 Ptges3 Cyb5b Cyp2j16 Adh7 Cyp4f39 Cyp21 Cyp2j3 Cyp11b3 Cyp4f1 Cyp4a14 Cyp2f2 Aoc1 Maob Cyp4f3 Cyp4a12 Cyp4f40 Cyp26c1 Cyp4b1 Cyp2a2 Acss2 Cyp2a1 Cyb5r3 Cyp4f4 Cyp4a10 Cyp4a2 Cyp2a3 Ces1d CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 96%10222007 Carbohydrate metabolism Aldoa Nup133 Nup210 Pfkl Nup155 Pgk2 Pck1 Nup153 Pfkm Pfkp Pck2 Pgm2l1 G6pc1 Pkml1 Gck Hk2 Hk3 Adpgk G6pc3 Naglu Tpi1l2 Hpse2 Hpse Sgsh Abcc5 Sdc4 Sdc3 Sdc2 Gpc1 Gpc3 Gpc2 Gpc5 Gpc4 Slc26a2 Gpc6 Slc26a1 Slc35b3 Slc35b2 Papss2 Papss1 Slc26a11 Man2b1 Sdc1 Slc35d2 Glb1l B3gnt7 B3gnt2 Kera Gns B4galt4 B4galt5 B4galt6 Prelp Glb1l3 Glb1l2 Fmod Galns Uxs1 Hexa Hexb Ugp2 B4gat1 Lum Omd Chst1 Chst3 Chst2 B4galt2 Man2c1 B4galt3 Acan Chst6 Ogn Cd44 Tkfc Aldh1a1 Manba Glyctk Sord Aldob Akr1b1 Khk Chp1 B3galt6 Cemip Fam20b B4galt7 Pxylp1 Chp1l1 Hyal2 Has1 Has2 Has3 Xylt1 Hs3st4 Xylt2 Hs3st1 Hs3st2 Extl2 Hs3st5 Hs3st6 Hs3st3b1 Bcan Hs2st1 Ndst1 Vcan Ndst2 Ndst3 Ndst4 Agrn Hs3st3a1 Hs6st3 Ncan Hs6st2 Hs6st1 Slc2a1 Dcn Ext2 Ext1 Pgk1 Rpe Taldo1 Prps1l3 Pgd Prps1 Rpia Dera Prps2 Shpk Pgm2 Pgls Tkt Rbks Dsel Ust Dse Cspg5 Bgn Cspg4 Chst14 Chst15 Idua Hyal4 Hyal3 Ids Hyal1 Gusb Calm3 Slc9a1 Akr1a1 Arsb B3galt1 Fut2 Fut1 Fut4 B4galnt2 Fut7 Fut9 B3galt5 B3galt4 Abo2 Dcxr Cryl1 Xylb Hyal5 Gale Galt Galm Galk1 Ctsl Phkg1 Gaa Gbe1 Phkg2 Agl Pygl Pygm Phkb Ppp1r3c Gys1 Akr1e2 Phka1 Phka2 Gyg1 Pgm1 St6galnac6 Slc17a5 St3gal6 St3gal4 St3gal2 St3gal3 G6pdx St3gal1 Nup93 Nup50 Glb1 Nup35 Nup54 Nup98 Nup58 Nup37 Pom121 Gnpda1 Nup205 Gpi Nup107 Gnpda2 Eno3 Sec13 Eno2 Eno4 Nup188 Tpr Pfkfb4 Pfkfb3 Nup160 Pfkfb2 Rae1 Pfkfb1 Pc Pgam2 Ndc1 Chst11 Pgam1 Chst12 Slc37a4 Chsy1 Tpi1 Nup85 Chsy3 Slc37a2 Nup42 Chst13 Slc37a1 Nup62 Chpf Nup43 Hkdc1 Nup88 Csgalnact2 Fbp1 Chst7 Fbp2 Aaas Chst9 Gckr Pklr Ranbp2 Gapdhs Nup214 B3gnt3 Aldoc Bpgm ENDOGENOUS STEROLS%REACTOME DATABASE ID RELEASE 96%10223155 Endogenous sterols Cyp39a1 Ncoa2 Cyp8b1 Cyp1b1 Cyp7b1 Nr1h4 Fdx1 Cyp4v2 Cyp46a1 Cyp27a1 Cyp7a1 Pomc Arnt2 Arnt Ahrr Ahr Cyp11a1 Fdx2 Fdxr Cyp21 Cyp11b3 Cyp11b1 Cyp11b2 Cyp19a1 Rxra DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-RNO-212676.1 Dopamine Neurotransmitter Release Cycle Rims1 Tspoap1 Syn3 Syt1 Syn2 Stx1a Ppfia3 Syn1 Cask Ppfia2 Ppfia4 Ppfia1 Lin7a Lin7b Stxbp1 Lin7c Unc13b Snap25 Apba1 Slc18a2 Cplx1 Vamp2 Rab3a FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 96%10223851 Free fatty acid receptors Ffar3 Ffar1 Ffar2 TELOMERE MAINTENANCE%REACTOME%R-RNO-157579.1 Telomere Maintenance Terf2 Acd Terf1 Terf2ip Tinf2 Pot1 Ccna1 Ccna2 Ppp6r3 Chtf8 Ppp6c Blm Wrn Chtf18 Tert Ctc1 Stn1 Ten1 Dscc1 Dna2 Shq1 Dkc1 Nhp2 Pif1 Gar1 Wrap53 Rtel1 Nop10 Rpa1 Ankrd28 Rpa2 Rpa3 Lig1 Fen1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Rfc2 Cdk2 Pola1 Pold4 Pold3 Prim2 Prim1 RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-RNO-8934903.1 Receptor Mediated Mitophagy Csnk2b Csnk2a2 Map1lc3b Map1lc3a Csnk2a1 Atg5 Fundc1 Atg12 Ulk1 Pgam5 Src ABO BLOOD GROUP BIOSYNTHESIS%REACTOME%R-RNO-9033807.1 ABO blood group biosynthesis Fut2 Fut1 Abo2 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 96%10225467 Regulation of MITF-M-dependent genes involved in pigmentation Myo5a Rab27a Myrip Sytl2 DEATH RECEPTOR SIGNALING%REACTOME%R-RNO-73887.1 Death Receptor Signaling Itgb3bp Mib2 Otulin Ube2d3 Usp2 Ube2d2 Xiap Usp4 Tradd Cflar Rhoa Ngef Stub1 Ripk1 Tnfsf10 Fas Sos1 Fadd Faslg Rbck1 Ube2l3 Ikbkb Usp21 Mapk8 Traf6 Ikbkg Map3k7 Smpd2 Nfkb1 Smpd3 Traf2 Sharpin Tnf Otud1 Tnfrsf1a Traf1 Rela Spata2 Rnf31 Rack1 Clip3 Sppl2b Sppl2a Ripk2 Casp8 Tbk1 Mapkapk2 Irak1 Tax1bp1 Nfkbia Ikbke Cyld Nsmaf Tab3 Rasgrf2 Tab2 Tab1 Chuk Ngf Birc2 Arhgef7 Tiam1 Mcf2l Tiam2 Prkci Rac1 Adam17 Bcl2l11 Madd Arhgef15 Arhgef17 Arhgef16 Sqstm1 Arhgef11 Arhgef10 Optn Arhgef12 Arhgef19 Rps27a Vav3 Akap13 Vav1 Vav2 Itsn1 Arhgef26 Arhgef25 Psenen Psen1 Psen2 Ulk1 Sos2 Kalrn Ncstn Aph1a Bex3 Arhgef6 Aph1b Arhgef5 Arhgef4 Arhgef2 Uba52 Gna13 Arhgef1 Obscn Ube2d1 Fgd2 Arhgef9 Fgd1 Fgd4 Arhgef37 Abr Fgd3 Arhgef39 Arhgef38 Arhgef33 Ect2 Prex1 Trio Bad Casp3 Casp2 Plekhg5 Myd88 Plekhg2 Ubb Net1 Arhgef10l Ubc Ywhae Otud7b Ngfr Mag Mcf2 Omg Arhgdia Rtn4 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-RNO-392170.1 ADP signalling through P2Y purinoceptor 12 Gng7 Gng8 Gngt1 Gnat3 Gnb2 Gnb1 Gnai2 Gnai1 Gnb4 Gnb3 Gnai3 Gnb5 Gng11 P2ry12 Gng10-ps1 Gng3 Gng5 Gng4 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-RNO-4090294.1 SUMOylation of intracellular receptors Sumo3 Pias4 Pgr Ube2i Vdr Esr1 Nr1h4 Ppara Thrb Thra Rara Nr5a1 Hdac4 Sumo2 Nr1i2 Pias3 Nr5a2 Pias1 Pias2 Nr1h3 Ar Nr1h2 Nr3c2 Sumo1 Nr3c1 Rxra SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME DATABASE ID RELEASE 96%10222913 Signaling by TGF-beta Receptor Complex Tgif1 Tgfb2 F11r Tgif2 Tgfb3 Ltbp3 Ltbp2 Cgn Furin Ltbp4 Ltbp1 Trim33 Ccnk Itgb8 Men1 Itgb6 Ccnt2 Nedd8 Itgb1 Ube2d3 Itgb3 Hdac1 Rnf111 Smad2 Smad3 Smad4 Mapk3 Smad7 Rhoa Stub1 Ski Rps27a Usp9x Skil Smurf2 Ccnc Atp1b4 Tgfbr3 Mtmr4 Uba52 Tfdp2 Tfdp1 Ube2d1 Tgfbr1 Tgfbr2 Rbl1 Strap Bambi Ube2m Prkcz Cdk9 Ubb Pard3 Ubc E2f4 E2f5 Parp1 Fkbp1a Ppm1a Ncor2 Pard6a Smurf1 Cbl Zfyve9 Mapk1 Wwtr1 Sp1 Itga8 Itgav Tgfb1 AUTOPHAGY%REACTOME%R-RNO-9612973.1 Autophagy Map1lc3b Prkab2 Prkab1 Ube2d3 Ube2d2 Atg7 Tomm20 Src Prkn Usp30 Ube2l3 Pex5 Ube2n Atg3 Lamtor3 Mtmr14 Lamtor2 Rb1cc1 Uvrag Atg10 Atg13 Atg14 Tomm22 Chmp2b Atg5 Tbk1 Atg12 Gabarapl1 Mtmr3 Atg9a Pcnt Atg9b Atm Atg101 Chmp3 Pgam5 Tomm40 Chmp7 Ambra1 Chmp6 Wdr45b Wdr45 Arl13b Atg16l2 Mterf3 Atg16l1 Chmp4c Map1lc3a Pink1 Chmp4bl1 Fundc1 Tomm7 Wipi2 Wipi1 Atg4b Atg4c Nbr1 Atg4a Atg4d Csnk2a2 Csnk2a1 Park7 Csnk2b Sqstm1 Optn Rps27a Tsc2 Tsc1 Ulk1 Pik3c3 Chmp2a Gabarap Dync1h1 Uba52 Pik3r4 Dync1i2 Dync1i1 Gabarapl2 Ubb Ubc Mfn1 Mfn2 Rptor RragB Prkaa1 Prkaa2 Mtor Vdac2 Vdac3 Rheb Vdac1 Dync1li2 Becn1 Dync1li1 Tomm70 Slc38a9 Lamtor5 Dynll1 Lamtor4 Prkag3 Dynll2 Rraga Prkag1 Prkag2 Lamtor1 Rragc Rragd Mlst8 Cftr TRP CHANNELS%REACTOME%R-RNO-3295583.1 TRP channels Trpm2 Mcoln2 Trpm1 Trpc5 Trpc4 Trpm8 Trpm7 Trpm4 Trpc4ap Trpm3 Trpc7 Trpm6 Trpc3 Trpv5 Trpa1 Trpv4 Trpv6 Trpv1 Trpv3 Mcoln1 Trpv2 Trpc1 Mcoln3 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 96%10223591 Unfolded Protein Response (UPR) Atf6 Eif2ak3 Mbtps1 Eif2s3 Creb3l3 Eif2s2 Ern1 Crebrf Eif2s1 Atf6b PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 96%10224255 PI and PC transport between ER and Golgi membranes Pitpnb RHOC GTPASE CYCLE%REACTOME%R-RNO-9013106.1 RHOC GTPase cycle Lman1 Rhoc Ophn1 Vapb Myo9b Arhgap35 Fmnl3 Vamp3 Racgap1 Dlc1 Stard13 Pkn2 Rock2 Rock1 Ccdc187 Pkn1 Tjp2 Arhgap32 Mcf2l Cav1 Acbd5 Flot2 Arhgef17 Flot1 Arhgef11 Pik3r1 Rhoa Arhgef10 Arhgef12 Akap13 Vav2 Fmnl2 Arhgef25 Tfrc Arhgef5 Arhgef1 Abcd3 Abr Stx5 Slk Cavin1 Daam1 Prex1 Bcr Jup Arhgap5 Arhgap1 Stom Arhgef10l Mcam Rtkn Stk10 Maco1 Anln Iqgap3 Diaph3 Diaph1 Arhgap18 Depdc1b Cit Lbr Arhgef28 C1qbp Arhgap21 Mcf2 Arhgap26 Arhgdia VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-RNO-5218921.1 VEGFR2 mediated cell proliferation Sphk1 Pdpk1 Prkcb Plcg1 Prkcd Src Nras Prkca Prkcz Rasa1 Kras Hras Vegfa Kdr BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME DATABASE ID RELEASE 96%10225243 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives Ptgs2 Alox5 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 96%10224483 Ficolins bind to repetitive carbohydrate structures on the target cell surface Fcn2 Fcn1 Masp1 Masp2 GBP-MEDIATED HOST DEFENSE%REACTOME%R-RNO-9953170.1 GBP-mediated host defense Casp1 Pim1 Furin Gbp5 Actb Fnta Fntb Pggt1b Actg1 Sfn Gbp2 Gbp1 Gbp3 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-RNO-429914.1 Deadenylation-dependent mRNA decay Dcps Edc3 Dis3 Edc4 Nt5c3b Pan2 Pan3 Ddx6 Skic3 Skic2 Dcp1a Skic8 Dcp1b Eif4a2 Eif4a1 Lsm3 Lsm5 Lsm1 Lsm6 Eif4a3 Lsm7 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Exosc6 Exosc1 Dcp2 Paip1 Hbs1l Patl1 Exosc3 Exosc2 Eif4e Pabpc1 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME DATABASE ID RELEASE 96%10225177 Noncanonical activation of NOTCH3 Aph1b Ybx1 Psenen Psen1 Notch3 Psen2 Ncstn Aph1a FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME%R-RNO-190371.1 FGFR3b ligand binding and activation Fgf17 Fgf18 Fgf1 Fgf20 Fgf8 Fgfr3 Fgf9 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%10225413 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Pomt1 Ddost Pomt2 Furin Ctnnb1 Pcsk7 Pcsk6 Cdh1 Csnk2a2 Csnk2a1 Jup Mogs Ganab Csnk2b Canx Arhgap32 Spcs3 Spcs1 Spcs2 Pip5k1c Sec11c Sec11a Rpn2 Rpn1 Prkcsh Ostc Ost4 Tmem258b Dad1 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 96%10225087 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Hist1h2ai Cbfb Kmt2d Kmt2a Kmt2b Kmt2c H2ac18 Sin3a Sin3b Prmt6 Hist1h2bq Prmt1 Hdac1 Wdr5 Ash2l H2aj H2ab2 H3-3b Hist3h2ba Ep300 H2ac4 ENSRNOG00000068602 Zfpm1 Gata1 Setd1b Setd1a H2bc18 Runx1 Kat2b ENSRNOG00000066901 H2az2 Rbbp5 H2bc4 Hist1h4m H2bc1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-RNO-69017.1 CDK-mediated phosphorylation and removal of Cdc6 Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Psma1 Ccne1 Rps27a Ccne2 Psmd12 Psmd11 Ube2c Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Psmb5 Psmb4 Psmb7 Psmb6 Cdc6 Psmb1 Psmb3 Psmb2 Uba52 Anapc10 Ube2d1 Anapc16 Psma7 Anapc15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Ube2e1 Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Cdk2 Cdc16 KERATINIZATION%REACTOME%R-RNO-6805567.1 Keratinization Cdsn Klk5 Krtap24-1 Kazn Krtap13-1 Klk8 Krtap10-9 Sprr3 LOC120093742 Tgm1 Krtap11-1 Stfa2l3 Krtap31-2 Casp14 Krtap31-1 Evpl Krt33b Spink6 Cela2a Krt33a Spink5 Krtap2-4l1 Perp Krtap3-1 Klk12 Krt4 Pkp2 Krt2 Pkp3 Krtap3-2 Dsg3 Krt8 Lipk Krt7 Dsg4 Krt5 Dsc2 Krt9 Rptn LOC680428 Lipm Krt27 Klk14 Dsc3 Krt28 Jup Lipn Krt25 Dsp Krt26 Krtap29-1 Krt24 Dsg1 Krt20 Dsg2 LOC134481131 LOC102553726 Krtap5-8 Krt39 Krt36 Krt34 Krt35 Krt32 Krt31 AABR07001416.1 Krtap6-5 Krt18 Krt19 Krt17 Krt14 Krt15 Krt12 Krt13 Krt10 Krtap16-5 Pkp1 Ppl Krtap16-1 Dsc1 Krt6a Krt71 Krt78 Krt76 Krt77 Krt75 Krt72 Krt73 Krt40 Krtap1-3 Krtap1-1 Krtap1-5 LOC134478810 Krt82 Krt80 Krt85 Krt1 Krt86 Krt83 Krt84 LOC102551497 Klk13 GDP-FUCOSE BIOSYNTHESIS%REACTOME%R-RNO-6787639.1 GDP-fucose biosynthesis Fuom Gmds Fcsk Fpgt Gfus Slc35c1 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 96%10224305 HS-GAG degradation Gpc1 Gpc3 Agrn Gpc2 Gpc5 Gpc4 Gpc6 Idua Naglu Ids Hpse2 Hpse Sgsh Sdc1 Ctsl Sdc4 Sdc3 Sdc2 HEME SIGNALING%REACTOME%R-RNO-9707616.1 Heme signaling Pgrmc2 Xpo1 Apob Bach1 Ly96 Slc46a1 Apoa1 Hba1 Hbb Clec1b Tlr4 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME DATABASE ID RELEASE 96%10222147 GTP hydrolysis and joining of the 60S ribosomal subunit LOC120093247 Rpl36a Rplp2 AABR07072440.1 Rpl35al8 Rpl22l1 Rplp0 Rplp1 Rpl13a Rpl35al2 Rpl18a Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rpl12 Rpl10a Rps14 Rps15 Rps16 Rps17 Rpl4 Rps15a Rpl5 Rps18 Rpl3 Rps19 Rps2 Rps27 Rpsa Rpl35 Rps10 Rps11 Rpl36 Rps13 LOC134480579 Rpl37 Rps4x-ps13 Rpl38 Rps3a Rpl39 Rps27l Rpl8 Rps9 Rpl9 Rps7 Uba52 Rpl23a Rps8 Rpl6 Rps5 Rpl7 Rps26-ps13 Rpl30 LOC134486107 Rpl31 Rpl32 Rpl34 Rpl36al1 Rpl39l1 Rpl24 Rpl26 Rps3 Rps25 Rpl27 Rps4x Rpl28 Rps26 Rpl29 Rps28 Rps29 Rpl12-ps1 Ubc Rps20 Rps21 Rpl22 Rps23 Rps24 Rpl23 Eif5b Fau LOC120097744 Rpl36l5 Rpl36l3 Rpl3l Rpl27a Rpl31l15 Rps6 LOC100910714 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-RNO-1834941.1 STING mediated induction of host immune responses Stat6 Sting1 Nlrp4 Dtx4 Tbk1 Irf3 Ddx41 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-RNO-190704.1 Oligomerization of connexins into connexons Gjb1 CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-RNO-1234174.1 Cellular response to hypoxia Crebbp Cited2 Cul2 Ube2d3 Ube2d2 Arnt Psma4 Psma3 Psma6 Ep300 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Vhl Psmb1 Psmb3 Psmb2 Uba52 Eloc Ube2d1 Elob Psma7 Ajuba Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Hif1an Psmd6 Psmd8 Psmd2 Psmd1 Adrm1 Rbx1 Egln1 Egln2 Egln3 Epas1 Hif3a Wtip Limd1 Hif1a RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%10225187 RHOBTB2 GTPase cycle Myo6 Txnl1 Phip Stk38 Hsp90ab1 Cct7 Cct6a Hsp90aa1 Actb Hnrnpc Rbmx Tmod3 Cdc37 Tra2b Twf1 Cct2 Cul3 Rhobtb2 Actn1 Ddx39b Msi2 Srrm1 DNA DAMAGE REVERSAL%REACTOME%R-RNO-73942.1 DNA Damage Reversal Alkbh5 Fto NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%10224435 Non-integrin membrane-ECM interactions Dag1 Prkca Sdc1 Fgf2 Itgb1 Itgb3 Itgb4 Ddr2 Ddr1 Megf11 Itga2 Sntg2 Agrn Dtna Dtnb Sgcz Snta1 Sntb2 Sntb1 Drp2 Sgce Sgcd Utrn Sgcb Sgca Lama4 Sspn Dmd Sgcg Itga6 Sdc4 Sdc3 Sdc2 Itgav Vtn Tgfb1 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 96%10225101 Invadopodia formation Adam15 Adam12 Adam19 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 96%10224719 CD209 (DC-SIGN) signaling Raf1 Icam2 Relb Pak1 Nfkb1 Pak3 Prkaca Crebbp Prkacb Pak2 Lyn Cd209a Ep300 Rela Rps6ka5 Nras Fyn Kras Hras CELL CYCLE%REACTOME%R-RNO-1640170.1 Cell Cycle Ywhag Gsk3b Rbbp4 Rbbp7 Mapk3 Emd Ppp2r5b Ppp2r5a Ube2n Fbxw11 Ppp1cc Ppp1cb Ppp2r5e Nedd1 Mzt2b Haus7 Tuba1a Haus8 Cdk5rap2 Cep192 Kpnb1 Cep57 Pcm1 Ssna1 Tubg2 Tubg1 Cep63 Tuba1c Tubal3 Nme7 Rcc1 Cep152 Tuba4a Chmp2b Mapk14 Tubgcp2 Cc2d1b Prkcb Haus4 Spast Tubb2b Haus5 Tubb2a Haus6 Ist1 Pcnt Hdac8 Sfi1 Chmp3 Vrk1 Haus1 Tubgcp6 Chmp7 Tubgcp5 Chmp6 Tubgcp4 Lmna Vps4a Tubgcp3 Sirt2 Cep250 Tuba8 Cep290 Cep78 Chmp4c Cep76 Tuba3b Cep72 Chmp4bl1 Tubb6 Cep164 Cep70 Tubb3 Cpap Tubb1 Mapk11 Tubb5 Banf1 Plk4 Ran Odf2 Ywhab Alms1 Cetn2 Mzt1 Cep135 Cep43 Cep41 Cep131 Tubb4b Tubb4a Ninl Cdk11b Terf2 Acd Terf1 Terf2ip Tinf2 Pot1 Akt3 Akt2 Akt1 Optn Ccne1 Ccne2 Ppp2r3b Cdkn2b Cdkn2d Cdc25a Orc4 Orc6 Orc1 Rab1b Orc3 Kif23 Orc2 Cdt1 Gmnn Ptk6 Cdc7 Chmp2a Kif20a Cdc6 Ppp2r2a Mcm7 Mcm8 Dbf4 Dyrk1a Tfdp2 Tfdp1 Cks1b Cables1 Lin52 Rbl2 Lin54 Rbl1 Mcm3 Mcm4 Mcm5 Mcm10 Mcm2 Pole3 Pole2 Pole4 Lin9 Rpa1 Rpa2 Wee1 Lin37 Rpa3 E2f1 E2f2 E2f3 E2f4 E2f5 Cdkn1b Pole Cdkn1c Ywhae Lbr Rab1A Rab8a Akap9 Lyn Src Eml4 Wapl Chtf8 Blm Numa1 Wrn Pds5b Chtf18 Pds5a Ctc1 Cdca5 Stn1 Ten1 Dscc1 Dna2 Pias4 Mre11 Ube2i Kat5 Nbn Hus1 Atrip Chek1 Chek2 Ube2v2 Rad9a Rad9b Bard1 Top3a Firrm Clspn Rad17 Jak2 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Pola2 Kmt5a Rfc2 Atm Pola1 Atr Pold4 Tp53bp1 Pold3 Prim2 Prim1 Exo1 Rmi2 Fignl1 Rmi1 Brip1 Brcc3 Smarca5 Herc2 Rnf168 Sumo1 ABRAXAS1 Rnf8 Rhno1 Nsd2 Rad51 Rad50 Fbxl7 Phf8 Babam1 Babam2 Topbp1 Rbbp8 Brca1 Uimc1 Rad1 Pafah1b1 Zw10 Knl1 Ccnb2-ps2 Ska2 Ska1 Zwint Sfn Rps27 Plk3 Rcc2 Kif18a Nudc Dync1h1 Shq1 Spc24 Dkc1 Nhp2 Spc25 Pif1 Xpo1 Gar1 Phf20 Nuf2 Wrap53 Cdca8 Rtel1 Nop10 Incenp Dync1i2 Ndel1 Dync1i1 Cenpc Cenpa Csnk1a1 Ajuba B9d2 Ska2l1 Taok1 Nde1 Mad1l1 Cenpu Cenpt Cenpq Cenpp Nup93 Cenpo Cenpn Nup50 Cenpm Mis12 Cenpl Dmc1 Cenpk Nup35 Cenpi Nup54 Nup98 Cenph Cenpf Cenpe Clasp1 Clasp2 Nup58 Rangap1 Nup37 Pkmyt1 Clip1 Pom121 Sgo2 Nup205 Sgo1 Nup107 Cdc25c Sec13 Kif2a Kif2b Nup188 Kif2c Dync1li2 Tpr Pmf1 Nup160 Dync1li1 Ahctf1 Rae1 Mapre1 Ndc1 Dynll1 Dynll2 Kntc1 Nup85 Cop1 Mdm4 Nup42 Ndc80 Nup62 Nup43 Ywhaq Nup88 Ywhah Birc5 Aaas Ercc6l Ccnb2 Ranbp2 Ckap5 Csnk1e Nup214 Ywhaz Spdl1 Nup133 Zfp385a Nup210 Nup155 Bub1 Nup153 Itgb3bp Gtse1 Zwilch Nek9 Ctdnep1 Cnep1r1 Lpin3 Gins2 Lpin2 Gins1 Gins4 Gins3 Phlda1 Ofd1 Esco1 Esco2 Tert Tuba1b Ppp1r12b Ppp1r12a Vrk2 Mastl Arpp19 Hsp90ab1 Ankle2 Psma4 Ccna1 Psma3 Ccna2 Ube2s Psma6 Psma5 Psma2 Hsp90aa1 Psma1 Rps27a Psmd12 Psmd11 Ube2c Lmnb1 Psmd14 Psmd13 Cdc27 Cdc26 Cdc23 Skp2 Skp1 Cdc20 Psmb5 Psmb4 Psmb7 Psmb6 Ccnb1 Psmb1 Psmb3 Psmb2 Uba52 Mad2l1 Anapc10 Ube2d1 Bub1b Anapc16 Btrc Psma7 Anapc15 Aurka Aurkb Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Anapc5 Fbxo5 Anapc4 Anapc1 Anapc2 Fzr1 Ubb Anapc7 Ubc Nek2l1 Ube2e1 Psmb6l1 Npm1 Cdc14a Psmd7 Rb1 Psmd6 Psmd8 Plk1 Psmd2 Pttg1 Psmd1 Adrm1 Cul1 Cdk2 Cdc16 Cdk1 Mapk1 Actr1a Ppp2cb Ppp2ca Dctn1 Dctn2 Prkaca Rsf1 Oip5 Mis18a Cenpw Prkca Ppp2r5d Ruvbl1 Prkar2b Gorasp1 Ppp2r1b Ppp2r1a Nipbl Ncapd2 Mau2 Ncapg Smc4 Ppp6r3 Ncaph Smc2 Ppp6c Csnk1d Ccp110 Golga2 Ankrd28 Tpx2 Tp53 Lig1 Fen1 Set H2ab2 Rab2a Blzf1 Espl1 Ncaph2 Ccnh Ncapd3 Fkbpl H2ac4 Ncapg2 Gorasp2 Mcph1 Smc3 Bora Foxm1 Ppme1 Lcmt1 Mis18bp1 Hjurp Abl1 ENSRNOG00000066901 Cdc25b Obi1 Ccnd2 Ticrr Ccnd3 Ccnd1 Stag2 Stag1 Cdk7 Cdk6 H2ac18 Csnk2a2 Csnk2a1 Mnat1 Hist1h2bq Smc1a Hdac1 Csnk2b H2aj Hist3h2ba ENSRNOG00000068602 H2az2 H2bc4 Hist1h4m H2bc1 Hist1h2ai Rbx1 Cdk4 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-RNO-416550.1 Sema4D mediated inhibition of cell attachment and migration Rac1 Rnd1 Rras Met Sema4d Rhoa Arhgap35 Plxnb1 MITOTIC PROPHASE%REACTOME%R-RNO-68875.1 Mitotic Prophase Nup133 Nup210 Nup155 Nup153 Rab1A Phf8 H2ac18 Prkca Nek9 Ctdnep1 Cnep1r1 Lpin3 Lpin2 Hist1h2bq H2aj Gorasp1 Mapk3 Hist3h2ba Smc4 Emd ENSRNOG00000068602 Smc2 Lmnb1 Ccnb2-ps2 Numa1 Rab1b H2az2 H2bc4 Hist1h4m H2bc1 Ccnb1 Hist1h2ai Vrk2 Golga2 Mastl Arpp19 Nup93 Nup50 Nup35 Nup54 Nup98 Nup58 Rb1 Nup37 Set Pom121 Plk1 H2ab2 Nup205 Rab2a Prkcb Blzf1 Nup107 Sec13 Ncaph2 Ncapd3 Kmt5a Nup188 H2ac4 Vrk1 Tpr Ncapg2 Cdk1 Nup160 Gorasp2 Mcph1 Lmna Rae1 Mapk1 Ndc1 Nup85 Nup42 Nup62 Nup43 Nup88 ENSRNOG00000066901 Banf1 Aaas Ccnb2 Ranbp2 Nup214 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 96%10225507 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Cd274 Os9 Rnf5 Sel1l Prkab2 Prkab1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Rnf185 Psmd8 Prkaa1 Derl3 Psmd2 Prkaa2 Derl2 Psmd1 Adrm1 Erlin2 Erlin1 Vcp Prkag3 Prkag1 Prkag2 Erlec1 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 96%10222223 Signaling by Receptor Tyrosine Kinases Erbb2 Erbb3 Ereg Hnrnph1 Frs2 Frs3 Thbs2 Btc Ranbp9 Rasa1 Pdgfa Pdgfb Fgfr3 Fgfr4 Fgfr1 Fgfr2 Fgf16 Creb1 Fgf17 Col4a1 Fgf18 Col4a2 Fgf19 Braf Fgf10 Ptk2 Hbegf Ide Mapk3 Rps6ka5 Nras Grb2 Fyn Rap1a Kras Sos1 Rap1b Mapk13 Hras Tgfa Fgf20 Fgf23 Areg Atf1 Fgf22 Mapk7 Kit Vrk3 Kitlg Map2k2 Rps6ka3 Map2k1 Rps6ka1 Klb Irs1 Rps6ka2 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Dusp3 Fgf8 Fgf7 Dusp4 Fgf9 Grap2 Dusp7 Hgf Tec Dusp6 Egfr Hdac2 Shc3 Shc2 Mapkapk3 Mapk14 Prkcb Mapkapk2 Pdgfrb Pdgfra Ap2s1 Ralgds Ap2a2 Ap2a1 Ap2b1 Kl Sh3gl2 Mapk11 Flt3 Itgav Ywhab Wwox Nrg2 Furin Nrg3 Ltk Tnk2 Spred1 Met Alkal2 Alkal1 Spred2 Ptpn3 Csk Mapk12 Egf Atp6v0b Itgb1 Trib3 Atp6v0a4 Grb10 Itgb3 Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v0a1 Atp6v1c1 Atp6v0c Ptprf Them4 Eps15l1 Pde3b Tlr9 Atp6ap1 Insr Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Akt3 Atp6v0d2 Akt2 Atp6v0d1 Akt1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Dock3 Sh3gl3 Sh3kbp1 Dock7 Sh3gl1 Ptk6 Pik3c3 Pik3r4 Rab4a Sh2b2 Prkce Itga2 Mtor Epn1 Crk Mlst8 Kidins220 Galnt3 Arf6 Spry1 Pcsk5 Nedd4 Itga3 Pxn Pak1 Pak2 Lyn Yes1 Src Rhoa Lama4 Ptprz1 Wwp1 Tgfbr3 Gipc1 Ncf1 Ncf2 Ncf4 Aamp Chek1 Lck Thbs1 Igf2 Igf1 Rnf41 Jak2 Lrig1 Tns4 Tns3 Hgfac Hpn Rab4b Gga3 Ctsd Spint2 Spint1 Ranbp10 Cma1 Pcsk6 Cyba Cybb Plat Cul5 Megf11 Pik3ca Shc1 Cav1 Ptpn6 Gab2 Pik3r1 Pik3cb Jak3 Pik3r2 Pik3r3 Gab1 Irs2 Mst1 Mst1r Ptpru Grap Fer Pdpk1 Ctnnb1 Nckap1l Fam83b Crkl Pag1 Rapgef1 Ntrk3 Ntf3 Stub1 Cdc37 Polr2c Polr2a Polr2b Polr2g Polr2h Abi2 Abi1 Polr2e Polr2f Polr2i Polr2j Ncbp2 Nab2 Ncbp1 Dnal4 Egr2 Ptpn12 Gtf2f2 Gtf2f1 Ctnna1 Eps15 Brk1 Jup Nrp1 Nrp2 Shb Ctnnd1 Sh2d2a Elmo1 Axl Alk Mdk Srf Ptn Ptpn18 Ptk7 Bcar1 Wasf3 Ptpn1 Wasf2 Wasf1 Fam83a Diaph1 Fam83d Pdgfc Pdgfd Nckap1 Cyfip2 Cyfip1 Cilp Thbs4 Ntrk1 Ngf Plcg1 Plg Spp1 Fes Elmo2 Rock2 Arhgef7 Rock1 Nck2 Rac1 Pak3 Baiap2 Hsp90aa1 Rps27a Chd4 Sphk1 Uba52 Nck1 Prkcz Igf1r Hdac3 Ptpn2 Ubb Ubc Mmp9 Mapk1 Nos3 Stam Ins1 Ppp2cb Grb7 Ppp2ca Ins2 Prkaca Prkacb Prkcd Prkca Fgfrl1 Calm3 Ppp2r5d Flt1 Flt4 Vegfa Kdr Vegfd Vegfc Pgf Usp8 Vegfb Hgs Ppp2r1b Ppp2r1a Stam2 Flrt1 Flrt3 Flrt2 Ptbp1 Stat6 Stat3 Esr1 Stat1 Ptk2b Stat5a Stat5b Hdac1 Fgfbp3 Fgfbp1 Rbfox2 Esrp2 Esrp1 Tial1 Yap1 Tia1 Ep300 Spry2 Mknk1 Itch Vav3 Vav1 Vav2 Ptpn11 Psenen Psen1 Psen2 Ncstn Aph1a Aph1b Memo1 Hnrnpa1 Sgk1 Ntf4 Rictor Prr5 Bdnf Mapkap1 Ntrk2 Ap2m1 Clta Cltc Cbl Hnrnpf Hspb1 Cdc42 NUCLEOTIDE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%10222421 Nucleotide Excision Repair Chd1l Ino80 Ddb2 Ino80e Ppie Ino80d Ino80c Ino80b Usp45 Usp7 Rnf111 Ruvbl1 Rad23a Rad23b Sumo2 Gps1 Polr2c Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2i Polr2j Ube2n Gtf2h2 Ube2i Gtf2h1 Gtf2h3 Gtf2h5 Cops4 Ercc2 Cops2 Ercc3 Lig3 Znf830 Ube2v2 Lig1 Parp2 Parp1 Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Xrcc1 Ccnh Rfc2 Pold4 Pold3 Actl6a Pias3 Pias1 Sumo1 Cetn2 Sumo3 Xpc Xab2 Cdk7 Ercc1 Ercc4 Tcea1 Mnat1 Polk Prpf19 Actg1 Cops3 Cops6 Cops8 Isy1 Rps27a Ercc6 Uba52 Pole3 Cops7a Pole2 Cops7b Pole4 Rpa1 Rpa2 Mcrs1 Aqr Uvssa Ubb Rpa3 Ubc Pole Nfrkb Rbx1 Tfpt Actr5 Yy1 Actr8 Cops5 Xpa Ddb1 Cul4a Cul4b MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-RNO-390648.1 Muscarinic acetylcholine receptors Chrm1 Chrm3 Chrm2 Chrm5 Chrm4 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-RNO-391160.1 Signal regulatory protein family interactions Grb2 Cd47 Sirpa Tyrobp Skap2 Ptk2b Fyb1 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-RNO-5654693.1 FRS-mediated FGFR1 signaling Fgf17 Frs2 Fgf10 Frs3 Nras Grb2 Kras Sos1 Hras Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Kl Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgfr1 Fgf9 G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 96%10222577 G alpha (q) signalling events Rgs3 Rgs1 Rgs21 Rgs18 Prkcq Rgs19 Rgs13 Lpar5 Lpar3 Lpar1 Creb1 Hbegf Mapk3 Nras Grb2 Kras Sos1 Hras App Mapk7 Ednrb Ednra Rps6ka3 Rps6ka1 Trhr Rps6ka2 Egfr Avpr1b Avpr1a Tbxa2r Btk Gnrh1 Nmbr Fpr2 Ptgfr Nmb Oxtr Lpar6 Xcr1 Grpr Gpr17 Nms Nmu Cckar Nmur2 Gnrhr Nmur1 Ntsr2 Ntsr1 Brs3 Ptger1 Mchr1 Gpr132 Edn1 Edn2 Gast Edn3 Cckbr Agtr1 F2 Gpr39 Avp Gpr143 Grp Kiss1r Gcgr Nps Ptafr Prkch Prkce Mmp3 Gprc6a Cysltr2 Cysltr1 Prok2 Gpr4 Gcg Npsr1 Plcb4 Prok1 Plcb3 Mgll P2ry10 Mapk1 Plcb2 Plcb1 Gng10-ps1 F2rl1 F2rl2 F2rl3 Prokr2 Prokr1 Prkcd Dgka Gpr65 Gpr68 Dgkb Abhd6 Prkca Dgkd Dgke Dgkg Gna11 Adra1b Gna14 Adra1a Adra1d Gng3 Uts2 Grk2 Tacr1 Dgkh Gng5 Tacr3 Dgki Gng4 Tacr2 Dgkk Anxa1 Gnaq Dgkq Gng7 Gng8 Gngt1 Dgkz Casr Itpr3 Itpr2 Itpr1 F2r Ffar3 Bdkrb2 Ffar1 Gnb2 Daglb Bdkrb1 Gnb1 Ffar2 Nts Gnb4 Trpc7 Kng1 Gnb3 Trpc3 Gnb5 Gng11 Chrm1 Hrh1 Chrm3 Chrm5 Dagla Tac3 Tac1 Opn4 Pmch Ltb4r2 Oxt Trh P2ry2 Grm1 Grm5 Ffar4 Ghrl Htr2a Htr2c Htr2b Lpar4 Ltb4r Xcl1 Agt Kiss1 Ccl9 P2ry6 Ccl6 P2ry1 Uts2b Npffr1 Npffr2 Npff Abhd12 Hcrtr2 Hcrtr1 Cck Qrfprl Qrfpr Qrfp Hcrt Uts2r Pik3ca Pik3r1 Pik3r2 Pik3r3 Arhgef25 Kalrn Trio Rgs17 Rgs16 Rgsl1 Ghsr Rgs4 Rgs5 Rgs2 PRE-MRNA SPLICING%REACTOME%R-RNO-72163.1 pre-mRNA splicing Sde2 Slu7 Srrm2 Snrpepl2 Nkap Hnrnph2 Hnrnph1 Ppig Ppie Rbmx2 Cwc22 Cwc27 Cwc25 Prpf8 Wbp11 Snip1 Cwc15 Gpatch1 Magohb Pqbp1 Ybx1 Rbm22 Rbm17 Ddx46 Bud31 Ddx41 Ddx42 Cwf19l2 Rbmx Polr2c Tra2b Polr2a Acin1 Polr2b Bud13 Polr2g Polr2h Polr2e Polr2f Polr2i Polr2j Ncbp2 Ncbp1 Gtf2f2 Gtf2f1 Snrnp200 Phf5a Fam50a Znf830 Hnrnpr-ps2 Alyref Rnf113a1 U2surp Crnkl1 Rnf113a2 Upf3b Wdr70 Snrpa1 Steep1 C3h9orf78 Ptbp1 Eif4a3 Ppwd1 Gcfc2 Ccdc12 Rbm8a Sf3a1 Sf3a2 Sf3a3 Prkrip1 Sf3b1 Xab2 Sf3b3 Sf3b4 Sf3b5 Leng1 Mfap1al1 Ctnnbl1 Cactin Hnrnpa2b1 Srrt Nsrp1 Prpf19 Snrnp40 Prpf18 Eftud2 Fam32a Snrpn Cherp Yju2 Fus Casc3 Isy1 Cdc5l Srsf1 Plrg1 Srsf9 Srsf7 Srsf5 Srsf3 Srsf2 Hnrnpa3 Syf2 Puf60 Ppil4 Ppil3 Hnrnpa1 Ppil2 Ppil1 Sap18 Hspa8 Bcas2 Gpkow Rnps1 Smndc1 Pnn Cdc40 Aqr Prcc Pcbp2 Snrpf Pcbp1 Magoh Ddx39b Snrpg Snrpb Tfip11 Dhx8 Hnrnpr Hnrnpu Rbm10 Dhx38 Dhx35 Hnrnpc Snrpd1 Hnrnpd Hnrnpf Hnrnpk Hnrnpl Dhx16 Dhx15 Srsf19 Snrpd3 Srsf11 Srsf12 Srrm1 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-RNO-68689.1 CDC6 association with the ORC:origin complex Cdc6 Mcm8 Orc4 Orc6 Orc1 Orc3 Orc2 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%10222513 CREB1 phosphorylation through the activation of Adenylate Cyclase Prkar1a Prkar2a Prkar1b Prkar2b Prkaca Prkacb TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-RNO-1299316.1 TWIK-releated acid-sensitive K+ channel (TASK) Kcnk9 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 96%10224555 Regulation of HSF1-mediated heat shock response Nup133 Nup210 Nup155 Nup153 Gsk3b Hspa5 Hsf1 Hspa1b Hspa1a Mapk3 Hspa8 Rpa1 Nup93 Rpa2 Nup50 Hsph1 Dnajc2 Rpa3 Hspa1l Nup35 Hikeshi Hspa14 Nup54 Hspa13 Nup98 Rps19bp1 St13 Ywhae Nup58 Hspa12b Hspa12a Hspa2 Nup37 Bag5 Pom121 Bag3 Bag2 Nup205 Bag1 Mapkapk2 Nup107 Sec13 Dnajb6 Hspa9 Nup188 Hspa4 Tpr Nup160 Rae1 Mapk1 Ndc1 Sirt1 Nup85 Nup42 Nup62 Nup43 Nup88 Dnajb1 Aaas Ranbp2 Nup214 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-RNO-8878159.1 Transcriptional regulation by RUNX3 Runx3 Cbfb Ccnd1 Crebbp Ctnnb1 Tcf7 Tcf7l1 Tcf7l2 Tead4 Psma4 Smad3 Psma3 Smad4 Yap1 Psma6 Src Ep300 Psma5 Psma2 Tead3 Psma1 Rps27a Tead2 Psmd12 Psmd11 Psmd14 Psmd13 Kat2b Psmb5 Psmb4 Smurf2 Psmb7 Psmb6 Lef1 Psmb1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Tp53 Psmb6l1 Kat2a Maml3 Psmd7 Rbpj Psmd6 Hdac4 Psmd8 Maml1 Psmd2 Maml2 Psmd1 Adrm1 Smurf1 Tgfb1 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME%R-RNO-209543.1 p75NTR recruits signalling complexes Uba52 Prkci Irak1 Ngf Sqstm1 Rps27a Ngfr Myd88 Ikbkb Ubb Ubc Traf6 Ripk2 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 96%10222345 Beta oxidation of butanoyl-CoA to acetyl-CoA Echs1 Hadh Acads DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%10224699 DAG1 core M1 glycosylations Pomt1 Pomgnt1 Pomt2 Dag1 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 96%10224629 RHO GTPases Activate NADPH Oxidases Pik3r4 Mapk14 Rac1 Nox3 Prkcb Nox1 S100a9 Mapk3 Prkcd Rac2 S100a8 Noxa1 Ncf1 Ncf2 Noxo1 Prkca Ncf4 Cyba Mapk1 Cybb Prkcz Mapk11 Pik3c3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%10223903 Mitochondrial tRNA aminoacylation Ppa2 THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 96%10222203 The phototransduction cascade Grk4 Nmt2 Metap1 Metap2 Camkmt Gucy2e Sag Gucy2f Cnga1 Pde6a Pde6b Gnat1 Rcvrn Guca1b Guca1a Calm3 Nmt1 Rho Gngt1 Gnb1 Gnb5 Fnta Fntb Rgs9bp Ppef1 Pde6g Rgs9 Grk1 Cngb1 KERATAN SULFATE DEGRADATION%REACTOME%R-RNO-2022857.1 Keratan sulfate degradation Omd Acan Ogn Glb1l Kera Gns Prelp Glb1l3 Glb1l2 Glb1 Fmod Galns Hexa Hexb Lum PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%10223047 PI-3K cascade:FGFR1 Fgf17 Pik3ca Frs2 Fgf10 Pik3r1 Grb2 Fgf2 Ptpn11 Fgf1 Fgf20 Fgf4 Kl Fgf23 Fgf3 Fgf6 Fgf5 Fgf22 Fgf8 Fgfr1 Fgf9 Gab1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-RNO-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol Cyp39a1 Hsd3b7 Akr1d1 Amacr Cyp8b1 Akr1c18 Akr1c12l1 Akr1c19 Slc27a2 Akr1c21 Cyp46a1 Cyp27a1 Slc27a5 Akr1c3l1 Akr1c12 Akr1c1 Akr1c13 Akr1c9 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME DATABASE ID RELEASE 96%10222645 Aflatoxin activation and detoxification Cyp3a9 Cyp3a18 Mgst3 Acy3 Cyp3a1 Mgst2 Cyp1a2 Mgst1 Cyp3a62 Ggt1 Ggt5 Cyp2a2 Cyp3a2 Ggt7 Cyp2a1 Ggt6 Akr7a3 Akr7a2 Cyp2a3 Acy1a Dpep1 Dpep2 RA BIOSYNTHESIS PATHWAY%REACTOME%R-RNO-5365859.1 RA biosynthesis pathway Cyp26a1 Rdh11 Rdh10 Akr1c18 Rdh13 Akr1c12l1 Rdh14 Akr1c19 Adh4 Adh1 Akr1c21 Crabp1 Akr1c3l1 Aldh1a1 Akr1c12 Rdh7 Akr1c1 Akr1c13 Akr1c9 Dhrs4 Dhrs3 Aldh8a1 Aldh1a2 Aldh1a3 Cyp26b1 Dhrs9 Cyp26c1 Sdr16c5 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-RNO-75815.1 Ubiquitin-dependent degradation of Cyclin D Psmb6 Psmb1 Ccnd1 Psmb3 Psmb2 Uba52 Psma7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubb Ubc Psmb6l1 Psmd7 Psmd6 Psmd8 Psmd2 Psma4 Psmd1 Psma3 Adrm1 Psma6 Psma5 Psma2 Psma1 Rps27a Psmd12 Psmd11 Psmd14 Psmd13 Cdk4 Psmb5 Psmb4 Psmb7 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 96%10223089 Intestinal hexose absorption Slc2a2 Slc5a1 Slc2a5 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260410%WP42%RATTUS NORVEGICUS GPCRs class C metabotropic glutamate pheromone Grm7 Gabbr1 Grm6 Gabbr2 Grm8 Gprc5b Gprc5a Casr Gprc5d Grm1 Gprc5c Grm3 Grm2 Grm5 Grm4 VEGF RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260410%WP1965%RATTUS NORVEGICUS VEGF receptor signal transduction Sh2d2a Mapkapk2 Casp9 Bad Nos3 Shc1 Src Pxn Mapk1 Plcg1 Pgf Prkci Akt1 Grb2 Rac1 Hspbp1 Prkca Raf1 Vegfc Pik3r3 Vegfb WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP375%RATTUS NORVEGICUS Wnt signaling pathway Rhoa Mapk3 Mark2 Ctbp1 Wnt5a Cdh1 Ctbp2 Sox9 Tax1bp3 Skp1 Sfrp2 Csnk2b Ppp2ca Sfrp1 Tbp Dkk1 Pax2 Gsk3b Prkcg Prkcb Magi3 Axin1 Axin2 Ror2 Crybb2 Csnk1d Btrc Sall1 Cdc25c Senp2 Lef1 Ruvbl1 Vangl2 Lrp6 Csnk1a1 Nlk Dab2 Camk2g Lrp5 Camk2d Tfap2a Camk2b Camk2a Wnt3a Dvl1 Arrb2 Dvl2 Tmem97 Dvl3 Arrb1 Wnt7a Brd7 Wnt2 Wnt4 Wnt3 Jun Fzd2 Jup Ccnd1 Fzd4 Map1b Fzd9 Fzd8 Ctnnbip1 Ankrd6 Bcl9 Dlg1 Smad4 Dlg2 Mapk8ip1 Apc Dlg4 Cul1 Cdk1 Tcf4 Nr5a1 Hipk2 Mapk1 Akt1 Rac1 Prkca Raf1 Mapk9 Mapk8 Csnk2a2 Ctnnb1 Csnk2a1 Map3k7 PROXIMAL TUBULE TRANSPORTERS%WIKIPATHWAYS_20260410%WP3881%RATTUS NORVEGICUS Proximal tubule transporters Slc20a2 Slc22a6 Car15 Slc26a1 Atp1a1 Fxyd4 Slc22a5 Tctn2 Atp6v0a2 Atp6v0a4 Atp6v1e1 Atp6v1g3 Atp6v0e2 Atp6v0a1 Nherf2 Nherf1 Slc1a1 Atp6v0c Car7 Slc4a4 Slc38a7 Slc34a1 Slc6a19 Slc7a6 Slc7a7 Car2 Atp1b1 Slc9a3 Slc9a8 Slc13a3 Slc7a8 Atp6v1a Slc13a1 Slc7a9 Slc34a2 Slc13a2 Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Slc16a10 Atp6v1g1 Ca4 Slc22a8 Atp6v1d Ca14 Atp6v1h GLUCURONIDATION%WIKIPATHWAYS_20260410%WP1276%RATTUS NORVEGICUS Glucuronidation Ugt2b35 Ugt2b34 Ugt2a1 Ugp2 Ugdh Pgm1 Hk1 Ugt2b1 Ugt2b7 Pgm2 Pgm5 STATIN PATHWAY%WIKIPATHWAYS_20260410%WP145%RATTUS NORVEGICUS Statin pathway Lcat Abca1 Scarb1 Apoc1 Mttp Soat1 Hmgcr Lpl Apoe Cyp7a1 ATM SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP654%RATTUS NORVEGICUS ATM signaling pathway Cdkn1a Tp53 Rprm Casp9 Cdk1 Rb1 Sfnl1 Ccnb1 Ccne1 Casp3 Cycs Chek2 Gadd45a Necab3 Ccnd1 Cdk6 Brca1 Pmaip1 Bax E2f1 Bak1 TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260410%WP1280%RATTUS NORVEGICUS Transcriptional activation by Nfe2l2 in response to phytochemicals Nqo1 Aimp2 Maf Prkca Hmox1 Gclm Cebpb Nfe2l2 Ephb2 Mapk8 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP147%RATTUS NORVEGICUS Kit receptor signaling pathway Prkcb Socs1 Stap1 Mitf Grb10 Socs5 Socs4 Matk Socs6 Crkl Ptpru Csf2rb Cltc Jak2 Sh3kbp1 Cblb Vav2 Fgr Dok1 Hck Rps6ka1 Kit Tnfrsf10b Btk Spred1 Pik3r1 Mpdz Crk Sos1 Pik3r2 Spred2 Grb7 Rasa1 Ptpn6 Ptpn11 Abl1 Pik3cg Fyn Grap Lyn Plce1 Sh2b2 Stat5a Stat5b Map2k1 Tec Fes Stat3 Hras Bad Shc1 Src Mapk1 Plcg1 Akt1 Grb2 Prkca Raf1 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260410%WP139%RATTUS NORVEGICUS Nuclear receptors in lipid metabolism and toxicity Abca1 Cyp7a1 Nr1i3 Nr1i2 Abcb1a Abcd2 Cyp27b1 Abcd3 Cyp2c11 Abcb4 Cyp4b1 Rara Rarb Cyp2b2 Cyp8b1 Vdr Nr1h3 Ppard Ppara Pparg Abcg1 Abcc3 Cyp24a1 Abcg5 Abcc2 Cyp26a1 Cyp2e1 Abcb11 SELENIUM MICRONUTRIENT NETWORK %WIKIPATHWAYS_20260410%WP1310%RATTUS NORVEGICUS Selenium micronutrient network Tbxt Sod1 Ptgds Fads1 Ptgis Cat Pnpo Xdh Mt-co2 Mthfr Selenok Fads2 Tbxas1 Mt-co1 Gpx1 Selenop Gpx3 Gpx6 Alox5 Gsr Mtr Kmo GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260410%WP378%RATTUS NORVEGICUS GPCRs class B secretin like Calcr Adgre5 Ghrhr Gipr Gcgr Adgre1 Adgrl2 Adgrl3 Sctr Adgrl4 Adcyap1r1 Adgrl1 Glp2r Vipr1 Calcrl Glp1r Crhr2 Crhr1 CARDIOVASCULAR SIGNALING%WIKIPATHWAYS_20260410%WP590%RATTUS NORVEGICUS Cardiovascular signaling Casp3 Arhgef7 Erbb2 Col11a1 Stmn1 Hspa1b Tnc Map2k6 Pdgfra Hspb1 Rras2 Vegfd Col1a1 Wasf1 Vwf Egf Col4a1 Casp6 Capn6 Col5a1 Pgf Col4a2 Akt1 Cfl1 Casp2 Wnt2b Wnt2 Thbs2 Selenop Vav2 Mapk8 FRUCTOSE METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260410%WP3894%RATTUS NORVEGICUS Fructose metabolism in proximal tubules Tkfc Naglt1 Akr1b1 Fbp1 Slc2a5 Pfkp Hk1 Gpi Slc5a9 Tpi1 Psme3 Slc5a10 Sord Aldob G6pc1 Aldoa Khk Pfkl NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP517%RATTUS NORVEGICUS Notch signaling pathway Ctbp1 Aph1a Ctbp2 Ncstn Ncor2 Dtx2 Dtx3 Dtx4 Dll3 Dll4 Rbpjl Maml1 Dtx3l Hdac1 Mfng Hes1 Numb Hes5 Jag2 Jag1 Kat2a Rfng Crebbp Notch4 Numbl Notch1 Notch2 Lfng Notch3 Psen1 Psen2 Dvl1 Dvl2 Dvl3 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260410%WP547%RATTUS NORVEGICUS Complement and coagulation cascades Klkb1 Kng2 C2 Proc C6 C9 Serpind1 F13b Cd46 F10 C1s C1r F12 Plat Thbd Plau Pros1 Serpinc1 A2m Cpb2 Cd55 C1qc Vwf Cr2 Serping1 Cr1l Kng2l1 C3ar1 Serpinf2 Mbl1 Fgb Masp1 Masp2 Tfpi F2 C8b F3 C4a F7 F8 F9 Serpine1 Plaur Cfb C1qb Cfd C1qa Cd59b Cfh Cfi F2r Plg SMALL LIGAND GPCRS%WIKIPATHWAYS_20260410%WP161%RATTUS NORVEGICUS Small ligand GPCRs Ptger1 S1pr1 S1pr3 Lpar1 Mtnr1a Cnr1 Cnr2 Ptgdr Ptgir Ptger4 Ptgfr Ptger2 Ptafr Ptger3 HYPOTHETICAL NETWORK FOR DRUG ADDICTION%WIKIPATHWAYS_20260410%WP1281%RATTUS NORVEGICUS Hypothetical network for drug addiction Mapk3 Map2k1 Grm1 Grm5 Grin2a Camk4 Adcy1 Drd1 Grin1 Camk2b Adcy8 Drd4 Acta1 Nisch Mapk1 Krit1 Prkaca Terf2ip Gria2 Gria1 Ppa1 Prkce Grin2d Grin2c Grin2b INSULIN INDUCED PI3K AKT AND MAPK IN HEPATOCYTES%WIKIPATHWAYS_20260410%WP4229%RATTUS NORVEGICUS Insulin induced PI3K Akt and MAPK in hepatocytes Gys2 Mapk3 Rheb Rps6kb1 Foxk1 Foxo1 Akt1s1 Rps6 Sos1 Tsc2 Tsc1 Eif4e Gsk3a Mlst8 Bad Shc1 Mapk1 Grb10 Akt1 Grb2 Raf1 Rptor Ins1 Eif4ebp1 Irs2 Pik3c3 Mtor Acly Pfkfb2 Rps6ka1 Gys1 BIOSYNTHESIS OF ALDOSTERONE AND CORTISOL%WIKIPATHWAYS_20260410%WP508%RATTUS NORVEGICUS Biosynthesis of aldosterone and cortisol Cyp21a1 Hsd3b2 Cyp11b2 Cyp17a1 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260410%WP278%RATTUS NORVEGICUS Matrix metalloproteinases Tcf20 Mmp21 Mmp11 Cep295nl Mmp23 Mmp24 Mmp14 Mmp15 Mmp16 Mmp2 Mmp28 Mmp17 Timp3 Timp2 Timp4 Tnf Mmp9 Bsg TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260410%WP1289%RATTUS NORVEGICUS Type II interferon signaling IFNG Ptpn11 Socs3 Spi1 Cxcl10 Eif2ak2 Cxcl9 Ifnb1 Ifng Ifngr2 Oas1a Socs1 Ifngr1 Psmb9 Gbp1 Jak1 Nos2 Tap1 Ciita Irf4 Prkcd Reg1a Cybb Il1b Jak2 Irf1 Irf2 Irf8 Isg15 Hist1h2ao Irf9 Ifit2 HEXOSES METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260410%WP3916%RATTUS NORVEGICUS Hexoses metabolism in proximal tubules Eno3 Eno2 Pc Mpc1 Mpc2 Pdk4 Pgam2 Hk1 Slc2a2 Pdk3 Pgam1 Pdk2 Pdk1 Pdhb Gapdh Ldha Ldhb Dld Pklr Aldoc Pdha1 Pgk1 Slc5a1 Pck1 Slc5a2 Got1 Mdh1 Mdh2 Got2 Pdp1 Pdp2 Gpi Slc5a9 Tpi1 Psme3 Slc5a10 Sord Aldob G6pc1 Aldoa Acly Khk Pfkl Tkfc Akr1b1 Fbp1 Slc2a5 Pfkp Pdhx Eno1 BETA OXIDATION OF UNSATURATED FATTY ACIDS%WIKIPATHWAYS_20260410%WP418%RATTUS NORVEGICUS Beta oxidation of unsaturated fatty acids Eci1 Acadm Decr1 Hadha Hadhb G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP520%RATTUS NORVEGICUS G13 signaling pathway Rps6kb1 Pik3r2 Arhgef1 Arhgdib Map3k4 Iqgap1 Pak3 Pik3cd Iqgap2 Cdc42 Ppp1cb Diaph1 Tnk2 Cfl2 Rhpn2 Wasl Sh3rf1 Cit Rac1 Limk1 Cyfip1 Rock2 Rock1 Mybph Pkn1 Mapk10 Pip4k2a VEGFR 3 SIGNALING%WIKIPATHWAYS_20260410%WP1964%RATTUS NORVEGICUS VEGFR 3 signaling Mapk3 Casp9 Vegfd Bad Nos3 Shc1 Mapk1 Plcg1 Pik3cg Akt1 Grb2 Vegfc Itpkc Flt4 METHYLATION%WIKIPATHWAYS_20260410%WP1282%RATTUS NORVEGICUS Methylation Mat1a Inmt Hnmt Comt Pnmt Mat2a HYPERTROPHY MODEL%WIKIPATHWAYS_20260410%WP442%RATTUS NORVEGICUS Hypertrophy model Myog Jund Wdr1 Ankrd1 Hbegf Zeb1 Ifng Eif4e Il1a Dusp14l1 Ifrd1 Il1r1 Ccn1 Nr4a3 Atf3 Eif4ebp1 INSULIN SIGNALING%WIKIPATHWAYS_20260410%WP439%RATTUS NORVEGICUS Insulin signaling Mapk3 Gsk3b Prkcb Map2k6 Map3k4 Pik3cd Jun Mapk10 Pfkl Cyth3 Grb14 Trib3 Map3k9 Map3k8 Elk1 Map3k6 Map3k5 Mapk4 Stxbp1 Stxbp2 Stxbp3 Stxbp4 Prkaa1 Prkaa2 Akt2 Gyg1 Kif5b Cblc Prkcq Map3k3 Map3k2 Prkch Map3k1 Shc3 Shc2 Insr Flot2 Flot1 Map4k5 Map4k4 Map4k3 Rab4a Rps6kb2 Prkcz Egr1 Xbp1 Kif3a Tbc1d4 Pik3c2a Pik3c2g Map4k2 Ehd1 Map4k1 Ehd2 Snap25 Snap23 Lipe Igf1r Ikbkb Arf1 Pdpk1 Rhoj Rac2 Slc2a1 Slc2a4 Ptprf Foxo3 Cap1 Rrad Inpp4a Gab1 Fos Ppp1r3a Vamp2 Rps6ka3 Rps6ka4 Rps6ka5 Rps6ka6 Mink1 Rps6ka2 Sgk3 Sos2 Sgk2 Sgk1 Myo1c Enpp1 Map2k7 Ptpn1 Stx4 Arhgap33 Inppl1 Mapk12 Mapk13 Mapk14 Pten Map2k4 Map2k2 Rapgef1 Map3k10 Map3k11 Socs1 Map3k13 Map3k14 Mapk11 Grb10 Rptor Cblb Eif4ebp1 Irs2 Pik3c3 Mtor Rps6ka1 Gys1 Gys2 Rheb Rps6kb1 Pik3r1 Foxo1 Crk Sos1 Tsc2 Pik3r2 Tsc1 Eif4e Gsk3a Ptpn11 Pik3cg Sh2b2 Map2k1 Hras Shc1 Mapk1 Prkci Akt1 Grb2 Prkcd Rac1 Reg1a Prkca Raf1 Mapk9 Mapk8 Map3k7 RETINOL METABOLISM%WIKIPATHWAYS_20260410%WP1297%RATTUS NORVEGICUS Retinol metabolism Rxra Rbp4 Retsat Crabp2 Cd36 Rxrg Lrat Rlbp1 Scarb1 Lpl Rara Rarb Dhrs3 Aldh1a1 Sult2b1 Abcg5 Cd36l1 Rdh12 Cyp26a1 Aldh1a3 Cyp2e1 Rdh10 Adh5 Adh4 Cyp26b1 Adh1 Bco1 Sult1a1 Npc1l1 Rpe65 Rxrb Rbp7 Abcg8 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260410%WP1277%RATTUS NORVEGICUS Non homologous end joining Xrcc6 Rad50 Prkdc Xrcc4 GENETIC ALTERATIONS OF LUNG CANCER%WIKIPATHWAYS_20260410%WP1968%RATTUS NORVEGICUS Genetic alterations of lung cancer Cdkn1a Tp53 Smad4 Pik3cd Pik3ca Mapk1 Bmyc Dmp1 Egfr Rasl11b Rb1 Smad2 Akt1 Tgfb1 Tgfb2 Ccne1 Mdm2 Map2k1 Raf1 Necab3 Ccnd1 Crebbp Erbb2 E2f1 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP294%RATTUS NORVEGICUS p38 Mapk signaling pathway Map3k9 Tgfb2 Rps6ka5 Atf2 Elk1 Max Pla2g4a Map3k5 Mef2d Tradd Traf2 Hras Ripk1 Mapkapk5 Mknk1 Tgfbr1 Daxx Map2k6 Mapk14 Hspb1 Mapkapk2 Map2k4 Map3k1 Shc1 Cdc42 Grb2 Rac1 Map3k7 FOLIC ACID NETWORK%WIKIPATHWAYS_20260410%WP1311%RATTUS NORVEGICUS Folic acid network Msrb1 Tbxt Selenow Sod1 Ptgds Txnrd2 Cbs Ptgis Cat Pnpo Xdh Mt-co2 Mthfr Selenok Fads2 Mt-co1 Gpx1 Gpx3 Gpx6 Alox5 Gsr Mtr Kmo RELATIONSHIP BETWEEN GLUTATHIONE AND NADPH%WIKIPATHWAYS_20260410%WP2562%RATTUS NORVEGICUS Relationship between glutathione and NADPH Ugp2 Ugdh Pgm1 Pgam2 Gapdh Pklr Pgk1 Casp3 Bax Cdkn1a Tp53 Nqo1 Gclm Gpi Aldoa Pfkl Map3k5 Txn1 Ftl1 Nnt Fth1 Ptgr1 G6pd Kif1b Pgd Abcc1 Tfr2 Gstp1 Tkt Gapdhl6 Rpe Taldo1 Dpep2 Rpia Ugt8 Ltc4s Gsn Tfrc Gss Anpep Mapk8 Gck Alox5 Fas Gsr Pgls Pgm2 Dffa Eno1 Dffb NUCLEAR RECEPTORS%WIKIPATHWAYS_20260410%WP217%RATTUS NORVEGICUS Nuclear receptors Nr3c1 Rxra Nr2c2 Nr2e1 Hnf4a Esrra Esrrb Rxrg Nr2f6 Thrb Nr1d2 Thra Nr2f2 Nr2f1 Nr5a1 Rorc Nr1h2 Esr1 Esr2 Ror1 Nr5a2 Nr4a2 Nr1i3 Nr1i2 Rara Rarb Vdr Nr1h3 Ppard Ppara Pparg Rxrb APOPTOSIS%WIKIPATHWAYS_20260410%WP1290%RATTUS NORVEGICUS Apoptosis Igf1r Ikbkb Ikbkg Prf1 Birc5 Casp3 Tnfrsf1b Hells Bcl2l11 Tnfrsf1a Nfkb1 Traf1 Bcl2l2 Pmaip1 Xiap Bax Rela Bnip3l Bak1 Irf3 Tp53 Lta Irf7 Irf5 Fadd Irf6 Diablol1 Map2k4 Bid Tp73 Nfkbib Casp7 Tnfrsf25 Igf2 Nfkbia Chuk Faslg Tp63 Casp2 Jun Mapk10 Tnfrsf10b Pik3r1 Tradd Traf2 Ripk1 Map3k1 Casp9 Bad Akt1 Irf4 Irf1 Irf2 Fas Dffa Dffb ESTROGEN METABOLISM%WIKIPATHWAYS_20260410%WP1302%RATTUS NORVEGICUS Estrogen metabolism Sult1e1 Gstm1 Nqo1 Arsl Cyp1a1 Cyp1b1 Sult1a1 Comt GLUCOCORTICOID EFFECT ON TARGET GENE EXPRESSION%WIKIPATHWAYS_20260410%WP1963%RATTUS NORVEGICUS Glucocorticoid effect on target gene expression Nr3c1 Tsc22d3 Hspa4 Pla2g4a Rras Mt-co2 Anxa1 Nfkb1 Fkbp4 Nfkbia MIR219 IN OLIGODENDROCYTE DIFFERENTIATION AND MYELINATION%WIKIPATHWAYS_20260410%WP2811%RATTUS NORVEGICUS mir219 in oligodendrocyte differentiation and myelination Pdgfra Hes5 Zbtb18 Foxj3 Elovl7 Neurod1 Sox6 IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP44%RATTUS NORVEGICUS IL 5 signaling pathway Mapk3 Foxo3 Gsk3b Prkcb Nfkb1 Bax Mapk14 Rapgef1 Socs1 Nfkbia Crkl Jak2 Jun Hck Rps6ka1 Rap1gap Itgam Btk Pim1 Sox4 Pik3r1 Sdcbp Alox5ap Syk Hcls1 Pik3r2 Itgb2 Il5ra Gsk3a Unc119 Ptpn6 Il5 Ptpn11 Ptk2b Cdkn1b Pik3cg Lyn Sh2b2 Stat5a Atf2 Elk1 Stat5b Pla2g4a Stat3 Hras Shc2 Shc1 Mapk1 Jak1 Akt1 Grb2 Rac1 Prkcd Raf1 Mapk9 Alox5 Ctnnb1 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP94%RATTUS NORVEGICUS Hepatocyte growth factor receptor signaling Mapk3 Crk Sos1 Rasa1 Ptpn11 Pik3ca Ptk2b Gab1 Dock1 Fos Pak1 Itga1 Rap1a Rap1b Hgf Ptk2 Elk1 Itgb1 Map2k1 Met Stat3 Hras Pten Map2k2 Rapgef1 Src Pxn Mapk1 Grb2 Crkl Raf1 Jun Mapk8 Map4k1 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260410%WP140%RATTUS NORVEGICUS Myometrial relaxation and contraction pathways Prkcg Prkcb Nfkb1 Crhr1 Camk2g Camk2d Camk2b Camk2a Arrb2 Arrb1 Jun Atf3 Prkd1 Ets2 Rgs4 Rgs5 Rgs2 Gja1 Rgs3 Rgs1 Crcp Slc8a1 Rgs9 Rgs6 Rgs7 Prkcq Plcg2 Actb Myl4 Prkch Mylk2 Myl2 Rxfp2 Rxfp1 Atf5 Maff Pkib Calca Il6 Grk5 Grk4 Atf6b Prkcz Gnaq Pkia Grk6 Pkig Actg1 Gngt1 Oxtr Gucy1a1 Dgkz Gnb2 Gnb1 Gnb4 Gnb3 Rln1 Gng12 Itpr3 Gng13 Itpr1 Ryr2 Plcb3 Atp2a3 Atp2a2 Ywhaq Oxt Adm Ywhah Ywhag Gabpa Fos Ywhae Gsto1 Ywhab Adcy3 Adcy4 Nos1 Adcy2 Guca2b Adcy7 Guca2a Adcy5 Creb3 Adcy9 Cald1 Pde4b Prkacb Crh Prkar1a Prkar1b Rgs20 Lpar1 Rgs17 Igfbp3 Gng3 Adcy1 Rgs19 Gng2 Igfbp4 Vkorc1l1 Rgs14 Acta1 Gng7 Igfbp1 Rgs16 Pde4d Gng8 Actc1 Prkar2b Rgs10 Prkce Ackr5 Corin Ramp3 Atf2 Nos3 Plcg1 Prkcd Prkca Il1b SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260410%WP2132%RATTUS NORVEGICUS Serotonin and anxiety Prkcb Grin2d Ppp3ca Nlgn1 Adra1a Arc Plek Htr2a Htr2c Htr1a Fos Crh NUCLEAR FACTOR ERYTHROID DERIVED 2 LIKE 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP2376%RATTUS NORVEGICUS Nuclear factor erythroid derived 2 like 2 signaling pathway Mapk3 Sod1 Ldhb Gsk3b Prkcg Prkcb Map2k6 Rras2 Pik3cd Gstm1 Jun Rras Aldoa Crebbp Prkcq Actb Map3k1 Prkcz Actg1 Pik3c2a Pik3c2g Ugdh Slc2a1 Scarb1 Gsto1 Brca1 Map2k7 Cdkn1a Tp53 Nqo1 Mapk14 Hmox1 Gclm Nfe2l2 Acta1 Actc1 Prkce Pik3c3 Mapk7 Akr7a3 Akr7a2 Prkd3 Eif2ak3 Ube2k Pik3r1 Gstk1 Herpud1 Sqstm1 Acta2 Pik3r2 Prdx1 Abcc4 Nras Gstt2 Gstt1 Pik3ca Cdc34 Vcp Pmf1 Fyn Gstm5 Gstm6 Gstm3 Mafg Gstm4 Gstm2 Ubb Map2k1 Slc1a4 Mafk Actg2 Fosl1 Hras Bach1 Pik3c2b Dhcr7 Ephx1 Akr1a1 Slc35b1 Dnajc5 Aldh3a1 Xpo1 Txn1 Mgst3 Ftl1 Gsto2 Mgst2 Fth1 Mgst1 Cbr1 G6pd Gstm5l Pik3r5 Pik3r6 Abcc1 Psmc6 Mapk1 Psmc5 Abcc3 Gstp1 Psmc2 Psmc4 Prkci Psmc3 Dnajb4 Taldo1 Nqo2 Prkcd Fmo1 Sod3 Prkca Sod2 Raf1 Akr1b10 Usp14 Pik3r3 Ran Gss Mapk9 Mapk8 Gsr Map3k7 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260410%WP1301%RATTUS NORVEGICUS Mitochondrial gene expression Gabpb2 Prkar1b Tfam Pprc1 Polrmt Esrra Camk4 Gabpa Ppp3ca Tfb1m Tfb2m Mterf1 Ppargc1a Nrf1 Ppargc1b Myef2 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260410%WP502%RATTUS NORVEGICUS Nucleotide GPCRs Adora2b Adora2a P2ry6 Lpar6 Adora1 P2ry2 P2ry1 Lpar4 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260410%WP1300%RATTUS NORVEGICUS Aflatoxin B1 metabolism Akr7a2 Gstm1 Ephx1 Akr7a3 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260410%WP1296%RATTUS NORVEGICUS Homologous recombination Rad52 Pold4 Pold3 Fsbp Nbn Rad50 Pold2 Rad51 Pold1 Brca2 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260410%WP40%RATTUS NORVEGICUS Inflammatory response pathway Il2rg Lck Cd40lg Lamc1 Lamb1 Thbs1 Col1a1 Ifng Il5ra Il5 Col1a2 Cd86 Tnfrsf1b Cd40 Il4r Cd80 Tnfrsf1a Il2ra Il2rb Il2 Il4 Lama5 Vtn TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP457%RATTUS NORVEGICUS TNF alpha NF kB signaling pathway Nr2c2 Mark2 Csnk2b Ppp2ca Gsk3b Ikbkg Tnfrsf1b Tnfrsf1a Btrc Nfkb1 Rela Fadd Hspb1 Nkiras1 Nkiras2 Tbkbp1 Rps11 Nfkbib Rpl6 Casp7 Rps13 Pias3 Fbl Nfkbia Rpl30 Chuk Ube2i Dpf2 Kcnq1 Polr1b Casp2 Rnf216 Polr1a Polr1g Fbxw11 Polr1e Casp8ap2 Pkn1 Txlna Tank Gtf2i Actl6a Smarce1 Tifa Ube2d2 Polr2sl1 Flna Nfkbiz Glg1 Bag4 Ripk2 Ripk3 G3bp2 Dcaf7 Cul1 Cops3 Cav1 Capn3 Kpna6 Mcc Kpna3 Kpna2 Dap Bcl3 Hdac1 Rel Tab2 Map3k8 Ptk2 Ccar2 Traf4 Mcm7 Pfdn2 Traf6 Faf1 Crebbp Tnfrsf8 Ikbke Psmd12 Hdac2 Smarcb1 Akt2 Psmd13 Nfkb2 Alpl Rasal2 Akap8 Map3k3 Psmb5 Map3k2 Rpl8l1 Rack1 Map3k1 Cyld Fkbp5 Mcm5 Tnip2 Tnip1 Pdcd2 Nsmaf Zfand5 Commd1 Trpc4ap Psmd7 Prkcz Psmd6 Fancd2 Psmd3 Elp1 Ktn1 Pebp1 Lrpprc Mtif2 Ikbkb Ywhah Ywhag Gab1 Ywhae Ywhab Casp3 Map3k14 Prkaca Rps6kb1 Ptpn11 Cdc34 Tradd Traf2 Ripk1 Tnf Src Psmc2 Psmc3 Akt1 Csnk2a2 Csnk2a1 BETA OXIDATION META PATHWAY%WIKIPATHWAYS_20260410%WP372%RATTUS NORVEGICUS Beta oxidation meta pathway Cpt2 Acads Echs1 Cpt1a Acsl1 Gpd2 Lipf Acsl5 Acsl6 Acsl3 Acsl4 Hadh Lpl Dld Hadha Hadhb Acadm Tpi1 Pnpla2 Acadvl Acss2 Acat1 Gcdh Crat Lipe FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP504%RATTUS NORVEGICUS Fatty acid biosynthesis Decr1 Echs1 Pc Acsl1 Acsl5 Acsl6 Acsl3 Hadh Mecr Echdc3 Echdc1 Echdc2 Acaa2 Scd Fasn Acacb Acaca Acss2 Acly ID SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP397%RATTUS NORVEGICUS ID signaling pathway Igf1r Myog Smad4 Atf3 Pax2 Rb1 Hes1 Ccne1 Ccna2 Elk1 Flt1 Myod1 Elk4 Id2 Id1 Nfkb1 Kdr Id4 Id3 Tcf7l2 Rela Psmd4 Igf1 Ngf Lck Cd40lg Bmp6 Smad1 Rbl2 Bmp2 Rbl1 Pax8 Tert Smad5 Srebf1 Egf Myf5 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260410%WP1291%RATTUS NORVEGICUS Phase I biotransformations non P450 Ces2j Esd Lipa Pon3 Ces5a Pon1 Pon2 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260410%WP270%RATTUS NORVEGICUS Tryptophan metabolism Cyp4f1 Inmt Cyp2f2 Aadat Echs1 Cyp2d2 Ogdh Cyp7b1 Cat Aanat Afmid Aoc1 Dhcr24 Haao Asmt Hadh Kynu Cyp2a2 Cyp2a1 Ube3a Acmsd Ido1 Mdm2 Aldh1a1 Ddc Cyp2e1 Tph1 Cyp1a1 Aldh3a2 Cyp1b1 Aldh2 Aldh9a1 Acad10 Cyp2j3 Hsd17b10 Cyp2b15 Wars1 Cyp2j4 Prmt1 Gcdh Tdo2 IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP135%RATTUS NORVEGICUS IL 6 signaling pathway Mapk3 Foxo3 Ppp2ca Gab1 Fos Gsk3b Rb1 Casp3 Rps6ka2 Cd40 Nfkb1 Sgk1 Erbb2 Inppl1 Nlk Map2k6 Mapk14 Map3k4 Hspb1 Map2k4 Map2k2 Cebpb Tmem97 Jak2 Jun Eif4ebp1 Fgr Hck Btk Rps6kb1 Pik3r1 Foxo1 Sos1 Pik3r2 Eif4e Ptpn11 Ptk2b Fyn Hdac1 Lyn Ppp2r3b Ppp2r3a Hsp90aa1 Ptk2 Stat5a Ppp2r2c Stat5b Ppp2r2b Map2k1 Foxo4 Tec Mapt Fes Ppp2cb Stat3 Gab2 Crebbp Hras Cdk5r1 Ptpa Il6st Ppp2r5c Ppp2r5b Daxx Ppp2r5a Ncoa1 Socs3 Il6r Ppp2r2a Eif2a Bmx Mapkapk2 Cdk9 Casp9 Ppp2r1a Bad Ppp2r5e Cdk5 Shc1 Hnf1a Pxn Mapk1 Jak1 Plcg1 Il6 Akt1 Grb2 Rac1 Prkcd Raf1 Mapk8 Map3k7 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP66%RATTUS NORVEGICUS Steroid biosynthesis Hsd17b1 Hsd17b2 F13b Hsd17b7 Hsd3b5 Hsd3b2 Hsd17b3 Hsd3b1 Hsd17b4 Cyp17a1 ONE CARBON METABOLISM%WIKIPATHWAYS_20260410%WP1292%RATTUS NORVEGICUS One carbon metabolism Mat1a Gart Mthfr Mthfd1l Ahcy Folh1 Mtrr Dnmt3b Mthfd2 Ftcd Dhfr Ahcyl2 Bhmt Tcn2 Dnmt3a Mtr Aldh1l1 Shmt1 BRAIN DERIVED NEUROTROPHIC FACTOR%WIKIPATHWAYS_20260410%WP2148%RATTUS NORVEGICUS Brain derived neurotrophic factor Ngfr Ntrk2 Bdnf Serpine1 Map2k1 Raf1 Mapk1 Plat Plg PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260410%WP303%RATTUS NORVEGICUS Prostaglandin synthesis and regulation Ptgds Ednrb Ptgis Anxa8 Ednra Anxa6 Prl Cyp11a1 S100a6 Scgb1a1 Hsd11b1 Hsd11b2 Edn1 Hpgd Anxa5 Anxa4 Anxa3 S100a10 Ptgs1 Ptgs2 Pla2g4a Ptgdr Ptgir Ptger4 Ptgfr Ptger2 Ptger3 Ptger1 Tbxas1 Anxa1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260410%WP473%RATTUS NORVEGICUS GPCRs class A rhodopsin like Adora2b Ednrb Adora2a Ednra P2ry6 Lpar6 Adora1 P2ry2 P2ry1 Lpar4 Hcar1 Adra2a Ghsr Adra2c Adra2b Gpr161 Cxcr1 Npy1r Rrh Htr4 Or3a1 Htr6 Oprd1 Htr7 Or2h2 Gpr65 Or2h1 Gpr68 Cxcr4 Gpr63 Oprl1 Adrb1 Gpr173 Adra1b Gpr174 Adrb3 Galr2 Gpr171 Adra1d Galr3 Galr1 Cmklr1 Lhcgr Sstr5 Sstr4 Sstr3 Sstr2 Olr226 Sstr1 Avpr1b Mc5r Oprm1 Gpr75 Htr5a Tbxa2r C5ar2 Or7c70 Ffar3 Fpr1 Aplnr Bdkrb2 Nmbr Fpr3 Ffar1 Bdkrb1 Fpr2 Ffar2 Ccr10 Chrm1 Hrh1 Or2b2 Chrm3 Chrm2 Chrm5 Or2j3 Chrm4 Hrh2 Hrh3 Agtr1a Or5v1b Gpr85 Drd3 Or7a36 Drd5 Opn4 Xcr1 Lpar5 Opn3 Olr1073 Gper1 Gpr19 C3ar1 Sucnr1 Gpr18 Grpr Or6b1 Gpr15 Or2c1 Gpr17 Or13c7d Or5i1 Gpr12 Adora3 Or2t1 Cckar Opn1sw Npbwr1 Nmur2 Prlhr Npy5r Oxtr Ntsr2 Ntsr1 Brs3 Gpr25 Mc2r F2r Gpr27 Gpr22 Gpr21 Fshr Ccr9 Mchr1 Ccr7 Ccr6 Ccr5 Ccr3 Ccr2 Cckbr Agtr2 Npy4r Gpr37 Gpr39 Htr1d Htr1f Or11a4 Rgr Or14j1 Or3a1e Mc4r Or10j27 Mtnr1a Npffr1 Or2f2 Cnr1 Npffr2 Cnr2 Ptgdr Ptgdr2 Ptgir Or2f1 Ptger4 Rho Ptgfr Hcrtr1 Ptger2 Or5ap2b Ptafr Or2w1 Ptger3 Gpr37l1 Ptger1 Cysltr2 Cysltr1 Npy2r Ackr4 Gpr4 Gpr3 Ackr2 Drd1 Gpr6 P2ry10 Mc3r Drd4 Or2ag1 P2ry13 P2ry14 Mas1 F2rl1 Or10a4 Gpr50 Oprk1 Or10a5 F2rl2 F2rl3 Adra1a Htr2a Htr2c Htr1a ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260410%WP360%RATTUS NORVEGICUS Acetylcholine synthesis Pdha1 Ache Pcyt1a Ahsg Chat Pemt MRNA PROCESSING%WIKIPATHWAYS_20260410%WP529%RATTUS NORVEGICUS mRNA processing Rbm17 Linc00176 U2af1 Nxf1 Sf3a1 Sf3a2 Sf3a3 U2af2 Ncbp2 Ncbp1 Cd2bp2 Rbmx Snrpd1 Tra2b Celf4 Celf2 Pabpn1 Celf1 Snrpd3 Sf3b2 Sf3b3 Sf3b4 Rbm39 Sfswap Sf3b5 Srp54 Hnrnph2 Ppm1g Hnrnph1 Dicer1 Ddx20 Rngtt Smc1a Prpf4 Phf5a Prpf6 Prpf3 Prpf40a Prmt1 Scamp3 Hnrnpa2b1 Supt5h Cdc40 Rnmt Snrnp70 Clp1 Snrpb2 Xrn2 Spop Prpf8 Snrnp40 Prpf18 Dhx8 Hnrnpr Dhx9 Hnrnpu Papola Snrpb Snrpa1 Snrpa Clk2 Clk3 Clk4 Mettl3 Prp4k Ptbp1 Fus Sugp1 Sugp2 Srpk1 Cpsf4 Lsm7 Cpsf1 Hnrnpd Cpsf2 Cpsf3 Ddx1 Snrpepl2 Hnrnpk Hnrnpm Hnrnpab Cstf1 Ybx1 Clasrp Nudt21 Tmed10 Sfpq Prmt2 Cstf2 Dhx16 Cstf3 Dhx15 Srsf1 Ptbp2 Srsf9 Srsf7 Srsf6 Srsf5 Srsf4 Srsf3 Srsf2 Srek1 Srsf10 Srrm1 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP569%RATTUS NORVEGICUS IL 2 signaling pathway Nr3c1 Mapk3 Foxo3 Il2ra Nfkb1 Il2 Rela Il2rg Plcb1 Lck Jak3 Stam2 Cd53 Mapk14 Itm2b Stam Eif3b Tert Pik3cd Nmi Socs1 Chuk Crkl Jak2 Irs2 Mtor Rps6kb1 Pik3r1 Crk Syk Sos1 Pik3r2 Eif4e Ptpn6 Ptpn11 Pik3ca Ptk2b Pik3cg Fyn Lyn Stat5a Stat5b Map2k1 Ets2 Stat3 Gab2 Mknk1 Socs3 Rack1 Mapkapk2 Ybx1 Shc1 Mapk1 Jak1 Akt1 Prkcz Grb2 Raf1 Mapk9 Mapk8 INTRACELLULAR TRAFFICKING OF CFTR%WIKIPATHWAYS_20260410%WP1486%RATTUS NORVEGICUS Intracellular trafficking of CFTR Cftr Fblim1 Ezr Nherf1 Rab7a Rab11a ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP1299%RATTUS NORVEGICUS ErbB signaling pathway Rps6kb1 Crk Sos1 Hbegf Abl1 Gab1 Cdkn1b Egfr Gsk3b Ptk2 Stat5a Elk1 Map2k1 Hras Map2k7 Erbb2 Cdkn1a Cblc Bad Shc2 Camk2a Pik3r5 Src Egf Mapk1 Ereg Plcg1 Akt3 Pak4 Tgfa Nrg2 Grb2 Nrg1 Areg Btc Prkca Nrg4 Jun Nrg3 Eif4ebp1 Mapk8 Mtor REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260410%WP351%RATTUS NORVEGICUS Regulation of actin cytoskeleton Rhoa Mapk3 Arhgef7 Arhgef1 Pdgfra Rras2 Iqgap1 Pak3 Pik3cd Wasf1 Cdc42 Ezr Egf Cfl2 Pak4 Cfl1 Limk1 Rock1 Ins2 Rras Fgf2 Fgf1 Pip4k2a Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Pip4k2b Pfn1 Vcl Arhgef6 Myh10 Apc Nckap1 Pdgfrb Pdgfa Slc9a1 Ssh3 Fgfr3 Ssh2 Fgfr4 Dock1 Ssh1 Pak1 Chrm1 Itga1 Fgfr1 Fgfr2 Mylk Chrm3 Cyfip2 Chrm2 Ptk2 Arpc5 Chrm5 Cd14 Fgf16 Chrm4 Fgf17 Mapk4 Fgf14 Fgf18 Fgf19 Braf Fgf12 Fgf13 Fgf10 Fgf11 Enah Baiap2 Git1 Fgf20 Fgf23 Actb Rassf7 Gna12 Gna13 Fgd1 Bcar1 Pak6 Csk Pak2 Pak5 F2 Tmsb4x Arhgap35 Wasf2 Mos Pip5k1b Pip5k1a Actg1 Pik3c2a Pik3c2g F2r Gng12 Sos2 Ins1 Pik3c3 Pik3r1 Crk Sos1 Pik3r2 Nras Pik3ca Pik3cg Egfr Map2k1 Pik3c2b Pik3r5 Pxn Mapk1 Rac1 Raf1 Gsn Pik3r3 ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260410%WP4268%RATTUS NORVEGICUS Ethanol metabolism resulting in production of ROS by CYP2E1 Mafg Prkcb Cyp2e1 Map2k1 Nfe2l2 Mapk8 THICK ASCENDING LIMB TRANSPORTERS%WIKIPATHWAYS_20260410%WP3882%RATTUS NORVEGICUS Thick ascending limb transporters Car2 Atp1b1 Slc9a3 Atp1a1 Kcnq1 Slc4a7 Slc12a1 Slc9a2 Aqp1 Ca4 Kcnk12 Slc12a7 Kcnj16 Clcnkb Clcnka ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260410%WP557%RATTUS NORVEGICUS ACE inhibitor pathway Agt Kng2 Kng2l1 Bdkrb2 Nos3 Agtr2 Ace Agtr1b Ren PEPTIDE GPCRS%WIKIPATHWAYS_20260410%WP131%RATTUS NORVEGICUS Peptide GPCRs Gnrhr Fshr Cxcr6 Tacr1 Ednrb Ccr7 Tacr3 Ccr6 Tacr2 Ednra Ccr5 Tshr Ccr3 Tac4 Ccr2 Cckbr Agtr2 Npy4r Mc4r Ghsr Cxcr1 Npy1r Oprd1 Npy2r Cxcr4 Mc3r Oprl1 Galr2 Oprk1 Galr3 Galr1 Lhcgr Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Avpr1b Mc5r Oprm1 Fpr1 Bdkrb2 Nmbr Fpr3 Bdkrb1 Fpr2 Ccr10 Agtr1a C3ar1 Grpr Cckar Npy5r Ntsr2 Oxtr Ntsr1 Brs3 Mc2r GPCRS OTHER%WIKIPATHWAYS_20260410%WP409%RATTUS NORVEGICUS GPCRs other Gnrhr Fshr Adora2a Ednra Ccr5 Prokr2 Ccr2 Gpr162 Cckbr Adgrg1 Gpr61 Or1n1 Gpr176 Ghrhr Alg6 Gpr135 Htr1f Smo Adgrl2 Taar3 Adgrl3 Rxfp3 Taar2 Or3a1e Taar5 Gpr183 Or2a5 Hrh4 Cnr1 Gpr88 Celsr2 Or2f1 Uts2r Ltb4r2 Cxcr1 Ptgfr Lgr6 Or10a2 S1pr1 Htr7 Drd4 P2ry13 Adra1d Or10a5 Sstr2 Htr2a C5ar2 Chrm3 Chrm2 Grm1 Drd3 Grm8 Gpr18 Grpr Rxfp1 Gpr17 Ntsr1 F2r NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260410%WP146%RATTUS NORVEGICUS Nucleotide metabolism Impdh1 Nme2 Hprt1 Polg Adss2 Sat1 Srm Mthfd2 Dhfr Pold1 Prps2 Polb OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260410%WP1283%RATTUS NORVEGICUS Oxidative phosphorylation Mt-atp6 Mt-nd6 Atp5mc1 Mt-nd1 Ndufb6 Mt-nd3 Mt-nd4l Ndufb5 Mt-nd2 Ndufb8 Ndufb7 Atp5mc3 Atp5mf Atp5me Ndufv1 Ndufv3 Atp5f1a Ndufa10l1 Ndufab1 Ndufc1 Ndufc2 Ndufa2 Ndufa5 Gzmb Ndufa4 Atp5pb Gzmc Ndufa9 Ndufa8 Atp5pf Ndufb10 Atp5po Ndufs3 Ndufs2 Ndufs5 Ndufs4 Ndufs6 Mt-co3 Ndufs8 Mt-nd5 Adck2 Mt-nd4 Ndufb2 HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP574%RATTUS NORVEGICUS Hedgehog signaling pathway Cdk1 Igf2 Smo Hhip Ccnb1 Gli1 Gli3 Gli2 Ski Ptch2 Ptch1 Sufu Crebbp Sap18 Dyrk1a OSTEOCLAST%WIKIPATHWAYS_20260410%WP489%RATTUS NORVEGICUS Osteoclast Spp1 Tnfsf11 Ifnar1 Ifnb1 Atp6v1e1 Slc9a1 Trpv5 Itgb3 Zcchc2 Ctsk SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2541%RATTUS NORVEGICUS Sulindac metabolic pathway Msra Cyp1a1 Msrb2 WNT MYOFIBROBLASTIC ACTIVATION OF HEPATIC STELLATE CELLS%WIKIPATHWAYS_20260410%WP3649%RATTUS NORVEGICUS Wnt myofibroblastic activation of hepatic stellate cells Wnt3a Pparg GLUCOCORTICOID METABOLISM%WIKIPATHWAYS_20260410%WP305%RATTUS NORVEGICUS Glucocorticoid metabolism Akr1c14 Cyp11a1 Cyp21a1 Hsd11b1 Hsd11b2 Cyp17a1 P53 PATHWAY%WIKIPATHWAYS_20260410%WP655%RATTUS NORVEGICUS p53 pathway Tsc2 Cdk1 Sfnl1 Ccnb1 Ccne1 Casp3 Cycs Chek2 Gadd45a Cdk6 Pmaip1 Bax Cdkn1a Tp53 Rprm Igfbp3 Pten Sesn1 Ccng1 Bid Casp9 Chek1 Tp73 Zmat3 Serpinb5 Cdkn2a Shisa5 Adgrb1 Cd82 Perp Siah1 Mdm4 Ppm1d Rchy1 Serpine1 Fas G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260410%WP348%RATTUS NORVEGICUS G1 to S cell cycle control Mcm2 Pole2 Pola2 Ccng2 Creb3l4 Creb3l1 Orc5 Rpa3l1 Orc4 Orc6 Orc1 Orc3 Rpa2 Cdk7 Wee1 E2f2 E2f3 Rb1 E2f4 E2f5 Ccnb1 E2f6 Ccne1 Pole Cdkn1c Gadd45a Necab3 Creb3 Cdk6 E2f1 Cdkn1a Tp53 Rbl1 Ccnd1 Cdk1 Cdkn1b Mdm2 Mcm7 Mcm5 Atf6b Ccna1 Ccne2 Mnat1 Cdkn2b Tfdp1 Cdkn2c Cldn5 Pcna Ccnh Myt1 Mcm4 Mcm6 BURN WOUND HEALING%WIKIPATHWAYS_20260410%WP5057%RATTUS NORVEGICUS Burn wound healing Adora2b Ptgis Syk Ankrd1 Pdgfa Dll4 Gpr176 Casp3 Il10 Epo Arfgap1 Ccn2 Chp1 Syp Il1rl1 Glb1 Mmp9 Cdc25b Igf1 Tp53 Col1a1 Acta1 Col4a1 Il1b Jun FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260410%WP133%RATTUS NORVEGICUS Fatty acid omega oxidation Cyp3a2 Adh7 Adh6 Cyp2e1 Cyp1a1 Adh5 Adh4 Aldh2 Adh1 Acad10 Aldh1a1 Cyp4a2 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260410%WP173%RATTUS NORVEGICUS Oxidative stress response Sod1 Txnrd2 Nqo1 Nfix Mapk14 Txn2 Cyba Cat Hmox1 Junb Mgst1 Xdh Gstt2 Fos Sod3 Cyp1a1 Sod2 Mapk10 Gpx3 Nfkb1 Gsr EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP1284%RATTUS NORVEGICUS EPO receptor signaling Mapk3 Sos1 Ptprc Map2k2 Shc1 Rasa1 Socs1 Src Pdk1 Mapk1 Pik3cg Akt1 Grb2 Stat5a Ptpru Stat5b Map2k1 Raf1 Epo Jak2 Stat3 Irs2 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260410%WP302%RATTUS NORVEGICUS Proteasome degradation Psmd12 Psmd13 Psmd4 Psmb5 Psma5 Rpn2 Psma2 Rpn1 Psmc6 Psme2 Psmb9 Psmc5 Psme1 Psmc2 Psmd11 Psmc4 Ube2b Psmc3 Uchl3 Psmb8 Psmd7 Psmb6l1 Psmd6 Psmb4 Psmb7 Psmd3 Psmd8 Uchl1 Psmb1 Psmd2 Psmd5 Psmb2 Ube2d3 Ube2d1 Psma7 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260410%WP227%RATTUS NORVEGICUS Osteoblast signaling Tnfsf11 Slc34a1 Pdgfra Fgf23 Col1a1 Pdgfrb Bglap Pth CFTR ACTIVITY IN THE PLASMA MEMBRANE%WIKIPATHWAYS_20260410%WP1488%RATTUS NORVEGICUS CFTR activity in the plasma membrane Plcz1 Plcb2 Plcb1 Pdzk1 Plcb3 Rack1 Cftr Ezr Ppp2ca Prkaca Prkcg Nherf2 Nherf1 Prkaa2 Snap23 LIPID DROPLET METABOLISM%WIKIPATHWAYS_20260410%WP3901%RATTUS NORVEGICUS Lipid droplet metabolism Lpin3 Aup1 Acsl1 Gpat2 Gpd2 Lpin1 Plin2 Bscl2 Dgat2 Acsl3 Agpat5 Soat1 Dgat1 Agpat3 Fitm2 Agpat4 Agpat1 Agpat2 Lipa Pnpla2 PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260410%WP282%RATTUS NORVEGICUS Pentose phosphate pathway Rpe Taldo1 Rpia G6pd Kif1b Pgd Pgls Tkt CATECHOLAMINE SYNTHESIS%WIKIPATHWAYS_20260410%WP513%RATTUS NORVEGICUS Catecholamine synthesis Th Pah Ddc Dbh Pnmt STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260410%WP316%RATTUS NORVEGICUS Striated muscle contraction Acta2 Tnnt3 Tnnt2 Tnnt1 Tnnc2 Tnnc1 Tmod1 Tpm4 Tpm3 Tpm2 Neb Tnni3 Tnni2 Tnni1 Myh3 Actn2 Actn3 Mybpc3 Myh8 Actn4 Vim Myl2 Myl9 Myh6 Acta1 Actc1 Actg1 TNF ALPHA AND MUCUS PRODUCTION IN LUNG EPYTHELIUM%WIKIPATHWAYS_20260410%WP1487%RATTUS NORVEGICUS TNF alpha and mucus production in lung epythelium Ikbkb Ripk2 Sos1 Shc1 Muc2 Tlr4 Mapk1 Nfkbia Chuk Egfr Il6 Tgfa Grb2 Ikbkg Map2k1 Rps6ka2 Raf1 Tnfrsf1a Tradd Nfkb1 Traf2 Tnf Rela TRANSLATION FACTORS%WIKIPATHWAYS_20260410%WP149%RATTUS NORVEGICUS Translation factors Eif2s2 Eef2k Eif2ak3 Eif2b1 Eif4h Paip1 Eif1 Eif1ax Eif6 Eif4a2 Eif4e Eif4a1 Etf1 Gspt2 Cluh Eif2ak2 Eif3b Eef1a2 Eef1d Eif3j Pycr3 Eif2s3 Eif2ak1 Eef1g Eif4ebp2 Eif3f Eif4g1 Eif4g3 Eif3a Eif1a Eif4ebp1 Eif5b Eif5a Eif2b3 Eif2b2 Eif2b5 Eif2b4 Kcnq2 MONOAMINE GPCRS%WIKIPATHWAYS_20260410%WP276%RATTUS NORVEGICUS Monoamine GPCRs Htr5a Htr5b Htr1d Htr1f Chrm1 Hrh1 Chrm3 Chrm2 Chrm5 Adra2a Chrm4 Hrh2 Adra2c Adra2b Drd3 Htr4 Drd5 Htr6 Htr7 Drd1 Drd4 Adrb1 Adra1b Adrb3 Adra1d Adra1a Htr2a Htr2c Htr1a AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260410%WP1287%RATTUS NORVEGICUS Amino acid conjugation of benzoic acid Acss2 Glyat S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260410%WP1312%RATTUS NORVEGICUS S1P receptor signal transduction Mapk3 Plcb2 Plcb1 S1pr1 Mapk12 S1pr3 Plcb3 Mapk1 Smpd2 Akt3 Asah1 Sphk2 Akt1 Sphk1 Gnai1 Gnai3 Mapk4 Pik3c2b Akt2 SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260410%WP349%RATTUS NORVEGICUS Synthesis and degradation of ketone bodies Hmgcl Bdh1 Oxct1 Hmgcs2 EBV LMP1 SIGNALING%WIKIPATHWAYS_20260410%WP1278%RATTUS NORVEGICUS EBV LMP1 signaling Nfkb2 Ikbkb Ifnb1 Map3k14 Mapk1 Chuk Traf6 Pdlim7 Tradd Ccl5 Nfkb1 Mapk8 Rela Map3k7 ACETATE MEDIATED PROMOTION OF METABOLIC SYNDROME%WIKIPATHWAYS_20260410%WP3650%RATTUS NORVEGICUS Acetate mediated promotion of metabolic syndrome Ins2 Gast MISMATCH REPAIR%WIKIPATHWAYS_20260410%WP1295%RATTUS NORVEGICUS Mismatch repair Pcna Lig1 Msh2 Pold1 Rfc1 G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260410%WP73%RATTUS NORVEGICUS G protein signaling pathways Rhoa Gng12 Gng13 Itpr1 Plcb3 Adcy3 Prkcg Adcy4 Prkcb Gnai1 Gnai3 Adcy2 Adcy7 Adcy5 Adcy9 Pde4b Prkacb Pde7b Pde7a Prkar1a Akap7 Prkar1b Akap3 Akap4 Arhgef1 Akap1 Gnaz Gng3 Adcy1 Akap10 Akap11 Akap12 Adcy8 Akap9 Akap13 Pde8a Pde8b Kcnj3 Prkaca Pakap Pde4d Gna14 Gng8 Gnao1 Gnal Prkar2b Gng5 Prkce Pde4c Gnas Ppp3cc Ppp3ca Pde1c Pde1a Rras Gng11 Prkd3 Nras Slc9a1 Hras Akap8 Prkcq Gna12 Gna13 Prkci Prkcz Prkcd Gnaq Prkca Gngt1 Gnb2 Gnb1 Gnb3 IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP319%RATTUS NORVEGICUS IL 3 signaling pathway Mapk3 Rac2 Slc2a1 Ywhaq Ppp2ca Gab1 Ywhab Gsk3b Prkcb Birc5 Tnfrsf1b Bcl2l11 Nfkb1 Id1 Bax Lck Mapk14 Hspb1 Pik3cd Rapgef1 Cdc42 Prkaca Matk Crkl Csf2rb Jak2 Kcnip3 Fcer2 Bcl2l1 Dnm1 Hck Gata2 Mapk7 Il3ra Selp Rxra Il3 Pik3r1 Foxo1 Vcl Crk Syk Sos1 Pik3r2 Gsk3a Ptpn6 Ptpn11 Pik3ca Pak1 Fyn Rap1a Lyn Ptk2 Stat5a Atf2 Stat5b Map2k1 Mmp2 Tec Fes Stat3 Gab2 Hras Mmp9 Socs3 Spi1 Rara Bmx Rack1 Mapkapk2 Chek1 Bad Shc1 Src Pxn Mapk1 Jak1 Akt1 Rps6kb2 Grb2 Rac1 Prkca Raf1 Mapk9 Mapk8 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260410%WP469%RATTUS NORVEGICUS Glutathione metabolism Ggt5 Gpx2 Ggt1 Oplah Gclm G6pd Gstm5l Gstt2 Gstt1 Gstm6 Gstm3 Gstm2 Gss Gpx3 Anpep Gsr POLYOL PATHWAY%WIKIPATHWAYS_20260410%WP1303%RATTUS NORVEGICUS Polyol pathway Akr1b1 Sord Aldob Khk RENIN ANGIOTENSIN SYSTEM%WIKIPATHWAYS_20260410%WP376%RATTUS NORVEGICUS Renin angiotensin system Agt Ikbkb Mapk3 Itpr3 Itpr1 Agtr2 Fos Ikbkg Ptgir Map2k7 Rela Plcb1 Mapk13 Map2k4 Pak3 Mas1 Prkaca Pak4 Jak2 Jun Mapk10 Ctsg Cpa3 Mme Ace2 Enpep Ctsa Nln Cma1 Pik3ca Ptk2b Lnpep Itpr2 Pak1 Ptk2 Atf2 Elk1 Stat3 Agtr1a Prkcq Map3k1 Shc1 Pak6 Pak2 Mapk1 Pak5 Grb2 Rac1 Raf1 Mapk9 Anpep Mapk8 Ace Ren SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260410%WP1293%RATTUS NORVEGICUS Selenium metabolism selenoproteins Gpx2 Selenok Fos Selenbp1 Eefsec Crem Sp3 Selenof Sars2 Selenoi Sars1 Fabp1 Selenoo Selenos Nfkb1 Dio1 Selenot Dio2 Dio3 Selenov Rela Sephs1 Msrb1 Trnau1ap Selenow Txnrd2 Nfe2l2 Rpl30 Jun Selenop Gpx3 Gpx6 SPINAL CORD INJURY%WIKIPATHWAYS_20260410%WP2433%RATTUS NORVEGICUS Spinal cord injury C5 Mapk3 Ngfr Gdnf Ccl2 Bdnf Tacr1 Pla2g5 Mbp Cd47 Cxcl1 Sox9 Cxcl2 Pla2g6 Fcgr2a Ptpra Ncan Acan Xylt1 Fos Nox4 Rb1 E2f5 Nos1 Casp3 Gadd45a Necab3 Il2 Il4 E2f1 Tp53 Grin1 Col4a1 Rock2 Ppp3ca Anxa1 Ccnd1 Selp Il1a Cdk1 Il1r1 Tgfb1 Gja1 Mmp9 Btg2 Chst11 Fkbp1a Ptprz1 Cxcl10 Slit1 Slit2 Aqp4 Ccng1 Vim Slit3 Ifng Pdyn Rhoc Rgma Tlr4 Vcan Mapk1 Sema6a Lilrb2 Tnfsf13b Il6 Nos2 Zfp36 Gap43 Arg1 Prpg2 Egr1 Omg Plxna2 Prkca Epha4 Il1b Mag Rtn4r Pla2g2a Ntn1 Klk8 Rtn4 Gfap Bcan Tnfsf13 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP358%RATTUS NORVEGICUS MAPK signaling pathway Mapk3 Ntrk2 Bdnf Cacng8 Cacna1g Cacna1h Cacna1e Prkcg Cacng7 Ikbkg Cacna1f Cacna1c Cacna1d Cacna1a Cacna1b Cacng1 Tnfrsf1a Cacng4 Nfkb1 Cacng5 Cacng3 Cacna1s Map3k20 Rela Cdc25b Lamtor3 Rasgrp3 Stmn1 Rasgrp4 Rasgrp1 Flnc Nlk Map2k6 Rasgrp2 Map3k4 Flnb Hspb1 Stk4 Rras2 Tgfb3 Nf1 Ppp3cb Rasgrf2 Cdc42 Ppp5c Egf Pla2g4b Pla2g4e Arrb2 Pla2g4d Chuk Akt3 Tmem97 Faslg Nfatc1 Nfatc3 Cacna2d1 Arrb1 Cacna2d3 Cacna2d4 Dusp16 Ptpn7 Ptpn5 Jun Dusp3 Rras Ntf4 Fgf2 Dusp2 Mapk10 Fgf1 Hspa1l Fgf4 Dusp4 Fgf3 Ntf3 Fgf6 Dusp10 Fgf5 Dusp9 Fgf8 Dusp8 Fgf7 Cacnb4 Fgf9 Flna Cacnb1 Cacnb2 Taok2 Jund Taok1 Taok3 Mapk8ip1 Ntrk1 Mef2c Pdgfrb Rapgef2 Pdgfa Il1a Mapk8ip3 Il1r2 Fgfr3 Il1r1 Fgfr4 Pak1 Fgfr1 Fgfr2 Rap1a Tab2 Map3k8 Elk1 Cd14 Map3k6 Fgf16 Map3k5 Fgf17 Fgf14 Traf6 Fgf18 Fgf19 Braf Fgf12 Fgf13 Fgf10 Akt2 Fgf11 Nfkb2 Fgf20 Map3k2 Gna12 Map3k1 Pak2 Map4k4 Map4k3 Mos Map4k2 Map4k1 Gng12 Ikbkb Fos Rps6ka3 Rps6ka4 Casp3 Elk4 Sos2 Gadd45a Map2k7 Prkacb Tp53 Ngf Mapk13 Mapk14 Map2k4 Map3k11 Map3k13 Map3k14 Prkaca Crkl Ppp3cc Ppp3ca Crk Sos1 Nras Rasa1 Egfr Tgfb1 Tgfb2 Atf2 Map2k1 Pla2g4a Mapt Traf2 Hras Mapkapk5 Mknk1 Tgfbr1 Daxx Mapkapk2 Mapk1 Akt1 Grb2 Prkcd Rac1 Prkca Raf1 Il1b Mapk9 Mapk8 Fas Map3k7 IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP8%RATTUS NORVEGICUS IL 9 signaling pathway Il2rg Mapk3 Socs3 Jak3 Pik3r1 Shc1 Kat5 Il9 Ptpn11 Mapk1 Il9r Vcp Jak1 Akt1 Grb2 Stat5a Stat5b Map2k1 Stat3 Irs2 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260410%WP124%RATTUS NORVEGICUS Irinotecan pathway Ces1e Abcc2 Ces1d Ces2c Abcg2 Abcc1 Bche Ces1f TOLL LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP1309%RATTUS NORVEGICUS Toll like receptor signaling pathway Ikbkb Mapk3 Fos Ikbkg Cd86 Cd40 Cd80 Nfkb1 Ccl5 Map2k7 Rela Irf3 Irf7 Irf5 Map2k6 Mapk13 Fadd Mapk14 Map2k4 Pik3cd Nfkbia Chuk Akt3 Jun Mapk10 Pik3r1 Pik3r2 Pik3ca Pik3cg Tab2 Il12b Map3k8 Il12a Cd14 Ticam2 Map2k1 Lbp Traf6 Ly96 Tlr1 Ifna4 Ikbke Ifna1 Ripk1 Tlr8 Tnf Tlr7 Tlr6 Akt2 Tlr5 Nfkb2 Tlr3 Spp1 Tlr2 Cxcl11 Ifnar1 Ccl4 Cxcl10 Ccl3 Tollip Cxcl9 Map2k3 Ifnb1 Pik3r5 Tlr4 Mapk1 Il6 Akt1 Rac1 Il1b Pik3r3 Mapk9 Mapk8 Map3k7 WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260410%WP1288%RATTUS NORVEGICUS Wnt signaling pathway and pluripotency Rhoa Ctbp1 Wnt5a Ctbp2 Ppp2ca Plau Gsk3b Prkcb Axin1 Axin2 Lef1 Tp53 Lrp6 Nlk Lrp5 Wnt3a Dvl1 Dvl2 Tmem97 Dvl3 Wnt7a Prkce Wnt2b Wnt2 Wnt4 Wnt3 Jun Fzd2 Mapk10 Ccnd1 Fzd4 Fzd9 Fzd8 Apc Ppp2r3a Ppp2r2c Ppp2r2b Ppp2cb Fosl1 Crebbp Ptpa Prkcq Ppp2r2a Pafah1b1 Ppp2r1a Sox2 Wnt5b Wnt9b Ppard Wnt16 Fbxw2 Wnt11 Tcf7 Nkd2 Prkci Wnt6 Tcf7l1 Prkcz Cd44 Prkcd Pou5f1 Fzd3 Prkca Ccnd2 Nanog Ppm1j Mapk9 Ctnnb1 Map3k7 GLYCOGEN METABOLISM%WIKIPATHWAYS_20260410%WP160%RATTUS NORVEGICUS Glycogen metabolism Gys2 Agl Pygm Ugp2 Pgm1 Gsk3a Ppp2ca Gsk3b Ppp2r3a Ppp2r2c Ppp2r2b Ppp2cb Ptpa Ppp2r5b Ppp2r5a Gyg1 Ppp2r2a Ppp2r1a Gbe1 Phkb Calm2 Phka1 Phka2 Pygb Phkg1 Gys1 Phkg2 NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP1294%RATTUS NORVEGICUS Nod like receptor NLR signaling pathway Ikbkb Ikbkg Cd40 Ephb2 Mapk8 Chuk Rela Map3k7 INTERACTIONS BETWEEN CFTR AND OTHER ION CHANNELS%WIKIPATHWAYS_20260410%WP1485%RATTUS NORVEGICUS Interactions between CFTR and other ion channels Scnn1b Scnn1g Cftr Nherf1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260410%WP74%RATTUS NORVEGICUS Integrin mediated cell adhesion Pdpk1 Itgax Ilk Rac2 Itgav Itgae Itgal Vav3 Itgad Itgb8 Itgb6 Itga2b Itgb4 Itgb5 Tln1 Vasp Itga8 Itga6 Itga9 Itga3 Itga4 Itga2 Itga10 Capn9 Git2 Rho Cav3 Capn5 Arhgef7 Cav2 Capn7 Capn1 Capn2 Zyx Mapk12 Capns1 Map2k6 Pak3 Map2k2 Rapgef1 Cdc42 Capn6 Akt3 Pak4 Rock2 Rock1 Mapk10 Vav2 Mapk7 Itgam Vcl Crk Sos1 Pik3r2 Itgb2 Cav1 Capn3 Dock1 Pak1 Fyn Itga1 Rap1a Rap1b Ptk2 Itgb1 Map2k1 Mapk4 Hras Braf Itgb3 Akt2 Map2k3 Mylk2 Shc3 Bcar1 Shc1 Pak6 Src Pxn Pak2 Mapk1 Akt1 Grb2 Rac1 Raf1 Selenop ADIPOGENESIS%WIKIPATHWAYS_20260410%WP155%RATTUS NORVEGICUS Adipogenesis Nr3c1 Ptgis Nr2f1 Celf1 Pck1 Dvl1 Ins2 Lpin3 Lpin1 Plin2 Mef2c Bscl2 Ncor2 Agpat2 Trib3 Wnt5b Il6 Serpine1 Cfd Lipe Agt Slc2a4 Lpl Rb1 Scd Gadd45a Necab3 Id3 E2f1 Igf1 Cdkn1a Nampt Nrip1 Rbl2 Ahr Bmp2 Lifr Rbl1 Prlr Foxc2 Cebpb Twist1 Ebf1 Srebf1 Socs1 Mif Retn Lmna Mbnl1 Frzb Cntfr Gata3 Gata4 Gh1 Hif1a Gtf3a Ndn Cyp26b1 Cisd1 Pck2 Egr2 Irs2 Lif Bmp4 Bmp3 Gata2 Wwtr1 Bmp1 Hmga1 Rxra Plin1 Adipoq Epas1 Sfrp4 Foxo1 Klf15 Rxrg Ncor1 Ucp1 Gadd45b Pnpla3 Cebpd Ncoa2 Zmpste24 Asip Osm Dlk1 Mixl1 Mef2a Mef2b Tgfb1 Klf6 Klf5 Stat5a Lep Stat5b Spock1 Gdf10 Mef2d Stat3 Tnf Il6st Ncoa1 Socs3 Rara Nr1h3 Hnf1a Ppard Ppara Pparg Cyp26a1 Ppargc1a Fas P53 SIGNAL PATHWAY%WIKIPATHWAYS_20260410%WP656%RATTUS NORVEGICUS p53 signal pathway Igf1 Tp53 Rprm Igfbp3 Casp9 Bid Cdk1 Perp Siah1 Ccne1 Mdm2 Casp3 Ccnb3 Gadd45g Gtse1 Bbc3 Parp1 Pmaip1 Fas Bax ESTROGEN SIGNALING%WIKIPATHWAYS_20260410%WP1279%RATTUS NORVEGICUS Estrogen signaling Ikbkb Ilk Cdk7 Tbp Fos Esr1 Nfkb1 Brca1 Mapk14 Prkaca Chuk Jun Ccnd1 Sos1 Hdac1 Elk1 Map2k1 Crebbp Hras Braf Hdac3 Hdac2 Hdac5 Taf13 Taf12 Gtf2f2 Gtf2b Gtf2e1 Polr2c Polr2a Polr2b Gper1 Taf9 Polr2g Polr2h Shc2 Polr2f Polr2i Src Polr2j Gtf2h2 Mapk1 Gtf2h1 Gtf2h4 Gtf2h3 Ercc2 Akt1 Ercc3 Taf7 Grb2 Taf6 Taf5 Mnat1 Gngt1 Mapk9 Ccnh Gnb1 IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP355%RATTUS NORVEGICUS IL 1 signaling pathway Mapk3 Sqstm1 Il1a Il1r2 Ptpn11 Il1r1 Map2k1 Traf6 Nfkb1 Rela Capn1 Capns1 Tollip Nfkbib Map3k14 Mapk1 Nfkbia Plcg1 Chuk Akt1 Prkcz Il1rap Elp1 Peli1 Il1b Irak4 Irak3 Irak2 Sirpa Mapk8 Tab1 Il1rn Map3k7 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260410%WP632%RATTUS NORVEGICUS Cholesterol metabolism Rusc1 Apoc2 Fdft1 Lss Hmgcs1 Mvd Msmo1 Scarb1 Apoc1 Srebf1 Soat1 Hmgcr Lpl Apoe Fdps Dhcr7 Idi1 Mvk TCA CYCLE%WIKIPATHWAYS_20260410%WP347%RATTUS NORVEGICUS TCA cycle Pc Ogdh Pdk4 Fh Sdhc Pdk3 Sdhb Sdha Pdk2 Idh3b Pdhb Afdn Suclg1 Suclg2 Dld Pdha1 Mdh1 Mdh2 FOCAL ADHESION%WIKIPATHWAYS_20260410%WP188%RATTUS NORVEGICUS Focal adhesion Comp Ppp1r12a Tnn Gsk3b Tnr Arhgap5 Reln Col1a2 Lama2 Lama3 Lama4 Thbs4 Blk Srms Txk Chad Pdgfb Erbb2 Lama5 Tesk2 Vtn Tnk1 Col11a1 Ptk6 Col4a6 Tnc Ibsp Pelo Map2k6 Lamc1 Pdgfra Actn1 Lamb1 Thbs1 Col11a2 Lamb3 Pak3 Vegfd Col6a2 Col1a1 Pik3cd Lamc3 Styk1 Vwf Cdc42 Pip5k1c Egf Col4a1 Diaph1 Tnk2 Akt3 Col5a1 Col4a2 Pak4 Thbs2 Rock2 Rock1 Jun Ccnd1 Itgam Vcl Pdgfrb Itgb2 Pdgfa Cav1 Dock1 Pak1 Rap1a Mylk Rap1b Hgf Ptk2 Elk1 Itgb1 Met Mapk4 Braf Akt2 Actb Map2k3 Mylk2 Shc3 Bcar1 Pak6 Pak2 Pak5 Ccnd2 Actg1 Igf1r Pdpk1 Itgax Ilk Rac2 Itgav Itgae Itgal Itgad Itgb8 Itgb6 Itga2b Itgb5 Tln1 Vasp Itga8 Itga6 Itga9 Itga3 Itga4 Flt1 Itga10 Kdr Cav3 Cav2 Capn1 Igf1 Zyx Mapk12 Mapk14 Pten Map2k2 Rapgef1 Fgr Hck Mapk7 Pik3r1 Crk Sos1 Pik3r2 Pik3ca Pik3cg Egfr Fyn Map2k1 Hras Itgb3 Spp1 Bad Shc1 Pik3r5 Src Pxn Mapk1 Pgf Akt1 Grb2 Rac1 Raf1 Vegfc Selenop Vegfb Mapk9 Mapk8 METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260410%WP1286%RATTUS NORVEGICUS Metapathway biotransformation Chst10 Chst12 Cyp2u1 Chst13 Cyp4f18 Chst14 Cyp4f17 Sult1e1 Ndst1 Gstm1 Cyp4x1 Ndst3 Cyp1a1 Cyp1b1 Sult4a1 Sult1b1 Hs3st3b1 Gstm7 Gstcd Cyp51 Hs2st1 Tpmt Comt Naa50 Cyp46a1 Nat8 Nat1 Nat2 Inmt Hnmt Ephx2 Akr1b1 Nat9 Sult6b2 Naa40 Nat10 Hs3st3a1 Chst1 Sult2a1 Chst3 Sult2a6 Chst4 Chst6 Chst9 Naa30 Akr1c1 Zfp628 Gstz1 Hs3st2 Hs3st5 Hs3st6 Cyp2s1 Cyp4f39 Baat Naa20 Akr1d1 Kcnab2 Kcnab3 Cyp2r1 Fmo3 Fmo2 Fmo5 Hs6st3 Fmo4 Hs6st1 Cyp26c1 Gal3st4 Gal3st3 Ugt2b1 Glyat Cyp7a1 Gsto1 Sult2b1 Cyp26b1 Sult1a1 Akr7a3 Akr7a2 Cyp2f2 Gpx2 Gstk1 Cyp7b1 Cyp21a1 Cyp11b2 Cyp17a1 Gstm5 Gstm4 Ephx1 Cyp27b1 Akr1a1 Chst11 Mgst3 Cyp8b1 Mgst1 Gstp1 Cyp24a1 Cyp26a1 Cyp2e1 Fmo1 Akr1b10 Gss Gsr ANGIOTENSIN II SIGNALING ACUTE IN THICK ASCENDING LIMBS%WIKIPATHWAYS_20260410%WP3887%RATTUS NORVEGICUS Angiotensin II signaling acute in thick ascending limbs Itpr3 Pdpk1 Itpr1 Agtr2 Nox4 Itpr2 Prkcg Agtr1a Akt2 Plcg2 Pten Pde2a Agtrap Nos3 Arrb2 Mas1 Plcg1 Prkaca Akt3 Akt1 Gnaq Prkca Calm2 Dnm1 Agtr1b APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260410%WP487%RATTUS NORVEGICUS Apoptosis modulation by HSP70 Hspa1b Fadd Casp9 Map3k1 Bid Aifm1 Casp7 Casp6 Faslg Casp2 Casp3 Cycs Tnfrsf1a Mapk10 Nfkb1 Ripk1 Fas}