S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Enoph1 Adi1 Kyat1 Mri1 Apip L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III Mpst Got1 Cisd1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) Gad1 Gad2 ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II Cyp2a3 Cyp19a1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) Fads2 Elovl5 Hsd17b12 Ehhadh METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation Gcdh Echs1 Acat1 Acat2 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis Asns PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation Pecr Aldh3a2 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II Ubiad1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Inpp5d Itpka Inpp5f Synj1 Inpp5a Itpkc Itpkb Ipmk Bpnt2 Impa2 Pten Impa1 Inpp5k Inpp1 Synj2 Inppl1 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) Cbs Cth SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis Dhodh Rrm2 Tyms Rrm2b Cad Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Umps Nme7 Nme6 Ctps2 Ctps1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis Gphn SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 Asmt ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis Tm7sf2 Hsd17b7 Nsdhl Lbr &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis Acsm5 Acsbg2 Fads2 Acsl1 Acsm3 Acsbg1 Acsm4 Slc27a2 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II Rnmt Cmtr2 Cmtr1 Rngtt PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis Gstm4 Gpx4 Alox12 Alox5 Dpep1 Alox15 Ltc4s SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Pmvk Ggps1 Hmgcr Mvd Hmgcs2 Acat1 Acat2 Fdps Idi1 Hmgcs1 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation Gls2 Gls L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation Hgd Tat Fah Hpd NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation Adh6 Adh4 Maob Comt Aldh3a2 Tomt Aldh2 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II Nagk Amdhd2 Gnpda2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation Hal Uroc1 Mthfd1 Ftcd NADH REPAIR%BIOCYC%PWY-6938 NADH repair Naxe URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) Upb1 Dpys Dpyd SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds Plcb4 Plcb3 Pikfyve Ip6k1 Pik3c3 Ip6k2 Plcb2 Plcb1 Ip6k3 Sacm1l Pi4k2a Ippk Plcg1 Plcg2 Mtmr14 Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pip4k2c Pik3r2 Pik3r3 Pik3r4 Pip4k2a Pi4kb Plch2 Plcd1 Plcd4 Plcd3 Itpk1 Cdipt Pik3cg Pik3cb Pik3cd Pip4p2 Pip4p1 Inpp5d Pi4k2b Itpka Plcz1 Pik3c2b Synj1 Plce1 Inpp5a Pik3c2a Itpkc Pik3c2g Itpkb Fig4 Ipmk Mtmr3 Ppip5k1 Pip5k1c Pten Pip5k1b Inpp5k Synj2 Inppl1 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation Prodh1 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I Glo1 Hagh L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation Gpt ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss1 Acss3 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Smox Sat2 Sat1 L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis Pah ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing Tgm1 Aloxe3 Slc27a4 Cyp4f39 Alox12b Cers3 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis Dhodh Cad Umps GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation Pnp Gda Xdh SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation Sod3 Sod2 Sod1 Cat MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis Isyna1 Impa2 Impa1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) Ndufab1 Ndufc1 Ndufc2 Sdhd Sdhc Sdhb Sdha Ndufa11 Cox6a1 Cox7b Uqcrfs1 Ndufs1 Ndufs2 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs6 Mt-co3 Mt-co2 Ndufs8 Uqcrq Coxfa4 Ndufa1 Ndufa3 Ndufa5 Ndufa7 Ndufa6 Ndufa8 Ndufb11 Ndufb10 Cox7a2 Cox5a Cox5b Mt-co1 Cyc1 Mt-nd5 Mt-nd4 Ndufb2 Mt-nd6 Mt-nd1 Uqcrc2 Ndufb3 Mt-nd3 Uqcrc1 Mt-nd2 Mt-nd4l Ndufb8 Ndufb7 Ndufb9 Cox8a Ndufv2 Ndufv1 Ndufv3 Uqcr11 Ndufa10l1 Mt-cyb DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Dolk Dhrsx Dhdds Nus1 Srd5a3 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis Gart Paics Rrm2 Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 Adsl Impdh2 Impdh1 Ak3 Gmps Ak2 Ak4 Adss2 Ak7 Pfas Ak8 Atic Ppat Guk1 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) Nmnat1 Nmrk1 Nmnat2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt Gad1 Gad2 Glud1 Abat PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pdx Pgls UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) Coq5 Coq6 Coq7 Pdss2 Coq2 Coq3 Ubiad1 Coq4 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis Rrm2 Impdh2 Impdh1 Rrm2b Gmps Nme3 Nme2 Nme1 Nme7 Nme6 Guk1 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis Vps29 Shmt2 Psat1 Shmt1 Phgdh Psph PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage Dguok Nme3 Dck Nme2 Nme1 Nme7 Nme6 Guk1 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) Sult1a1 Dio1 Dio2 Ugt1a9 Ugt2b34l1 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation Gls2 Gls Asns VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle Vkorc1 Nqo1 Ggcx Vkorc1l1 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I Por Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Cyp1b1 Cyp1a2 Sult1a1 Ugt2b34l1 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation Ada Pnp GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I Gsta6 Gsta3 Gsta1 Gsta2 Anpep Gstm7 Gstm5 Gstk1 Gstm1 Nat8 Gstm2 Gsto2 Gstp1 Gstt2 Mgst2 Mgst1 Gstt1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Gart Mthfd1 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis Alox5 Lta4h Ptgs2 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I Agmat PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Chkb Selenoi Pcyt2 Cept1 Etnk2 Etnk1 CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Sqle Ebp Dhcr24 Sc5d Kcnh7 Tm7sf2 Dhcr7 Hsd17b7 Fdft1 Nsdhl Lss Lbr PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Nme7 Nme6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis Gpx4 Alox12 Alox15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) Dhtkd1 Aadat Pycr1 Pipox CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal1 Hyal5 Hyal4 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis Tyr ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis Atp5mc1 Atp6v1b2 Vps9d1 Atp6v0d1 Atp5mc3 Atp5mc2 Atp5mf Atp5me Atp6v0e1 Atp5mg Atp6v1g1 Atp5f1b Atp5f1a Atp6v1f Atp6v1d Atp6v1h Atp6v0b Atp5f1d Atp5f1c Atp5pb Atp6v1e1 Atpaf1 Atp6v0a1 Atp6v1c1 Atp5pf Atpaf2 Atp5po Atp6v0c Atp6v1a Mt-atp6 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation Mthfd1l Shmt2 Shmt1 Mthfd1 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis Vps29 Psat1 Phgdh Psph L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I Aspg Asrgl1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I Acod1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis Gart Pfas Ppat PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I Cda Uck1 Uck2 Uckl1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis Sqle Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Acat1 Acat2 Fdps Idi1 Hmgcs1 Pmvk Ggps1 Hmgcr Mvd Hmgcs2 Tm7sf2 Hsd17b7 Nsdhl Lbr PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III Arg2 Odc1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation Cda Upp1 Upp2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Hmgcs2 Acat1 Hmgcl Bdh2 Bdh1 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation Akr1a1 Cryl1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pip4k2a Pi4kb Plch2 Plcd1 Plcd4 Plcd3 Cdipt Plcb4 Plcb3 Pi4k2b Plcz1 Plcb2 Plce1 Plcb1 Pi4k2a Plcg1 Plcg2 Pip5k1c Pip5k1b Pip4k2b Pip4k2c ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV Acss1 Aldh3a2 Acss3 Aldh2 Cat CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) Cyp2e1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation Hsd17b10 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Echs1 Acadsb Acat1 Acat2 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis Agxt2 Agxt ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) Fads2 Elovl7 Fads1 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B3galt5 B3galt4 St8sia2 St8sia3 Ugcg St8sia1 St3gal6 St3gal4 St3gal5 St3gal2 B3galt1 B3gnt5 B3gnt2 Fut2 A4galt B4galt1 Fut1 B4galt2 B4galt3 B4galt4 B3galnt1 B4galt6 St6gal1 B4galnt1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I Hmox1 Hmox2 Blvra Ugt1a5 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis St8sia2 St8sia3 Ugcg St3gal6 St3gal4 B3gnt5 B3gnt2 B4galt1 B4galt2 B4galt3 B4galt4 B4galt6 St6gal1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fcsk Fpgt GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Gmds THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III Tpk1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation Upb1 Dpys Dpyd S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation Nnt CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation Aldh7a1 Chdh ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI Adk PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis Chkb Selenoi Gnpat Pcyt1b Pcyt1a Far2 Far1 Chka Peds1 Agpat1 Pcyt2 Cept1 Etnk2 Etnk1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis Tyr L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) Kmo Ido2 Acmsd Ido1 Dhtkd1 Kyat1 Tdo2 Aadat Haao Kynu Got2 Aldh8a1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) Cyp2a3 Cyp19a1 Hsd17b11 Hsd17b3 Hsd17b1 Hsd17b7 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) Acsm5 Fads2 Elovl5 Acsl1 Acsm3 Elovl7 Fads1 Acsm4 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation Suox HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis Hdc GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis St3gal5 St3gal2 B3galt4 Ugcg St8sia1 B4galt6 St6gal1 B4galnt1 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3galt5 B3galt1 Fut2 Abo2 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III Cyp2e1 Akr1b10 Akr1b1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat2a Mat1a PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation Enpp2 Tmem86b SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis Ctps1 Dhodh Cad Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Umps Nme7 Nme6 Ctps2 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ippk Ipmk Itpk1 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis Shmt2 Shmt1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis Fads6 Acot2 Scd1 Acot3 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis Ptgis Tbxas1 Cbr1 Hpgds Hpgd Akr1c18 Ptgs1 Ptgs2 Ptges Ptgr2 Ptgds Ptgr1 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation Inpp4b Pip4p2 Pip4p1 Inpp5d Inpp5f Synj1 Sacm1l Mtmr3 Pten Mtmr14 Inpp5k Synj2 Inpp4a Inppl1 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis Elovl4 Tecr Hsd17b12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) Ppcdc Coasy RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis Ephx3 Gpx4 Alox12 Alox5 Alox15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) Cyp2e1 Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis Ephx3 Dpep2 Cyp4f18 Cyp2j4 Cyp4f4 Cyp2d4 Alox15b Lta4h Ptgs2 Gstm4 Gpx4 Alox12 Alox5 Dpep1 Alox15 Ltc4s Ptgis Tbxas1 Hpgds Hpgd Ptgs1 Ptges Ptgr2 Ptgds Ptgr1 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination Padi1 Padi6 Padi2 Padi3 Padi4 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) Pah PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II Ptdss2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Inpp5d Itpka Synj1 Inpp5a Itpkc Itpkb Ipmk Pten Inpp5k Synj2 Inppl1 INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis Ip6k2 Ip6k3 Ippk Ipmk Ppip5k1 Ip6k1 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism Dio3 Dio1 Dio2 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway Txnrd2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis Alox5 Ptgs2 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate Acly KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Oxct1 Acat1 Bdh2 Bdh1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation Aldh1b1 Aldh3b1 Aldh3a1 Pgm2 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation Alox12 Alox5 Alox15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine Bhmt Bhmt2 Mtr SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation Por Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Cyp1b1 Cyp1a2 Sult1a1 Ugt2b34l1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Acmsd Dhtkd1 Aldh8a1 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions Gpx4 Gpx1 Gpx3 Gpx7 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage Nmnat1 Nmnat2 Nampt HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation Aoc1 Hnmt CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis Cds1 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Gpam Abhd5 Mboat2 Agpat3 Lclat1 Agpat4 Cds2 Agpat2 Agpat1 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Bpgm FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III Fa2h Hacl1 Aldh3a2 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis Pc Pgk1 Pgam2 Tpi1l2 Pgk2 Fbp1 Pck1 Fbp2 Bpgm Gpi Mdh1 Mdh2 Eno1 Gapdhs Aldob Aldoc Eno3 G6pc1 Eno2 Aldoa G6pc3 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I Aoc3 Maob Aldh3a2 Aldh2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Rpia Rpe Taldo1 Tkt VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II Tecr Hsd17b12 Elovl1 Elovl7 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) Acsm5 Acsbg2 Fads2 Elovl5 Hsd17b12 Acsl1 Acsm3 Elovl7 Acsbg1 Fads1 Acsm4 Slc27a2 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle Gclm Oplah Gclc Gss Cndp2 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I Ctps1 Ctps2 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis Hk3 Pygb Pygl Gck Pgm1 Hk2 Pgm2 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation Bckdhb Bckdha Dbt Abat Bcat1 Dld Hibch Bcat2 Echs1 Hibadh Aldh6a1 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) Ntan1 Ate1 Naa20 Ntaq1 Apeh Metap2 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis Alox5 Ptgs2 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis Got1l1 Got1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II Hk3 Gck Pgm1 Hk2 Pgm2 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II Tsen34 Rtcb Tsen15 Ddx1 Tsen54 Rtraf Fam98b Tsen2 C9h2orf49 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage Cda Tyms Dck Tk2 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis Rrm2 Tyms Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis Pycr1 Aldh18a1 Pycr2 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gstp1 Gsta3 Gsta1 Gsta2 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation Nt5e Nt5c3a Impdh2 Impdh1 Ada Pnp Gda Xdh Nt5c1a L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis Cbs Cth Ahcy Mat2a Mat1a L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle Srm Enoph1 Adi1 Kyat1 Mri1 Mat2a Apip Mat1a D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Inpp5f Synj1 Inpp5a Bpnt2 Impa2 Impa1 Inpp5k Inpp1 Synj2 Inppl1 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation Acadsb BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Bmpr2 Bmp2 Smad4 Acvr2a Zfyve16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Gstm4 Dpep2 Alox5 Lta4h Dpep1 Ltc4s PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis Hsd3b1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis Glud1 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II Rbp4 Rbp1 Xdh GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclm Gclc Gss DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation Maob Comt Aldh3a2 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis Ephx3 Alox12 Alox15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I Got1l1 Got1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis St3gal5 Ugt8 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I Sord PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate Ldhb Ldhc PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III Sat2 Sat1 Aldh1b1 Aldh3b1 Aldh3a1 Maob Aldh3a2 Aldh2 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1 Ckm Ckb QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) Qtrt2 Qtrt1 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation Bckdhb Bckdha Mccc1 Dbt Auh Bcat1 Ivd Dld Mccc2 Bcat2 Hmgcll1 Hmgcl GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation Aspg Asrgl1 Aga Got1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation Adh6 Sult1a1 Ugt2b34l1 Aldh3a2 Aldh2 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis Adsl Ak3 Ak2 Ak4 Adss2 Ak7 Ak8 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II Plaat1 Plaat5 Plaat3 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Kmo Ido2 Ido1 Tdo2 Haao Kynu UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis Uxs1 Ugdh PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases Plcb4 Plcb3 Plaat3 Plaat1 Plaat5 Plcb2 Plcb1 Pla2g2e Pla2g2d Pla2g2a Pla2g4e Pla2g4d Plcg1 Pld4 Plcg2 Pla2g4a Pld6 Pld1 Pld3 Plb1 Pld2 Pla2g12a Pnpla8 Pla2g5 Pla2g3 Pla2g6 Plch2 Pla2g1b Plcd1 Oc90 Plcd4 Pla2g10 Plcd3 Plcz1 Plce1 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis Srd5a1 Srd5a2 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I Sqle Ebp Dhcr24 Sc5d Kcnh7 Tm7sf2 Dhcr7 Hsd17b7 Fdft1 Nsdhl Lss Lbr OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis Gclm Gclc Got1 Gss COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis Ppcdc Coasy Pank3 Pank1 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation Tpi1l2 Aldob Aldoc Tkfc Khk Aldoa PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis Prps1l1 Prps1 Prps2 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage Cda Tyms Nme3 Dck Nme2 Nme1 Cmpk2 Cmpk1 Tk2 Nme7 Nme6 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis Chkb Chpt1 Pcyt1b Pcyt1a Chka Cept1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization Adh6 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp1a2 Aanat Tph2 Ddc Tph1 Asmt Tdo2 Haao Kynu Aldh8a1 Kmo Akr1a1 Ido2 Nmnat1 Cyp2a3 Acmsd Ido1 Nmnat2 Gcdh Echs1 Dhtkd1 Acat1 Acat2 Aldh3a2 Qprt Nadsyn1 Sult1a1 Maob Ugt2b34l1 Aldh2 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) Acsbg2 Hsd17b10 Acox1 Acox2 Scp2 Hsd17b4 Ehhadh Acaa1b Echs1 Hadh Acsbg1 Slc27a2 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine Akr1a1 Ddc Maob Aldh3a2 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging Cars1 Vars2 Wars2 Aars2 Rars1 Wars1 Aars1 Rars2 Kars1 Sars2 Sars1 Fars2 Eprs1 Nars1 Nars2 Tars3 Tars2 Iars1 Tars1 Hars1 Pars2 Dars2 Yars2 Yars1 Dars1 Lars2 Gars1 Qars1 Lars1 Farsa Farsb PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Amdhd2 Gnpda2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis Tat SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage Rrm2 Rrm2b Nme3 Ada Nme2 Nme1 Pnp Nme7 Nme6 Adsl Adk Impdh2 Impdh1 Ak3 Gmps Ak2 Ak4 Adss2 Hprt1 Ak7 Aprt Ak8 Guk1 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) Gdf1 Kdsr Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP Dctd Rrm2 Tyms Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis Ctps1 Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Nme7 Nme6 Ctps2 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine Aldh7a1 Shmt2 Chdh Dmgdh Shmt1 Bhmt TCA CYCLE%BIOCYC%PWY66-398 TCA cycle Fh Idh3a Dlst Idh3b Dld Cs Idh3g Suclg1 Suclg2 Ogdh Aco2 Mdh1 Mdh2 Sdhd Sdhc Sdhb Sdha N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis Emg1 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation Hadhb Acaa2 Acsbg2 Hsd17b10 Eci1 Scp2 Echs1 Hadh Acsbg1 Hadha Slc27a2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis Gdf1 Kdsr Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) Elovl7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II Adh1 Sord LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis St3gal5 B3galt5 B3galt1 B3gnt5 Ugcg Fut2 B4galt6 St6gal1 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation Sdsl TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling Pcbd1 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis Srm TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis Gch1 Spr Pts L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) Kmo Ido2 Acmsd Ido1 Gcdh Echs1 Dhtkd1 Acat1 Acat2 Tdo2 Haao Kynu Aldh8a1 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation Oga Ogt CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis Hccs RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I Sdr16c5 Rbp4 Rbp1 Aldh1a2 Aldh1a1 Aldh1a3 Rdh16 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide Fut9 Chst1 St8sia2 B4galt1 Fut1 Abo2 B4galt2 B4galt3 St3gal4 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation Nme3 Nme2 Nme1 Cmpk2 Cmpk1 Nme7 Nme6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation Cda Upb1 Upp1 Dpys Upp2 Dpyd THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) Dio3 Dio1 Dio2 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) Acsm5 Fads2 Elovl5 Acsl1 Acsm3 Fads1 Acsm4 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis Gcnt3 Gcnt2 B3gnt2 B4galt1 B4galt2 B4galt3 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) Eci1 Eci2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis Pgk1 Pgam2 Tpi1l2 Pgk2 Pklr Pfkl Pkm Pfkm Pfkp Bpgm Hk3 Gpi Gck Eno1 Hk2 Gapdhs Aldob Aldoc Eno3 Eno2 Aldoa HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) Cbs Cth HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B3galt5 Gcnt3 B3gnt2 Fut2 B4galt1 B4galt2 B4galt4 Lalba St6gal1 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation Nt5e Impdh2 Impdh1 Pnp Xdh HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Fech Cpox Urod Ppox MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle Cpt1a Cpt2 Cpt1b Cpt1c Slc25a20 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis Tyr Dct Trpc1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) Ndufab1 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis B3galt5 St3gal2 Ugcg Fut2 A4galt Fut1 B3galnt1 B4galt6 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation Hk3 Gck Hk2 Treh LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis Ephx3 Cyp2c11 Ephx1 Ephx2 Ephx4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) Rdh11 Rdh12 Rdh10 Rpe65 Rbp2 Rbp3 Dhrs9 Lrat Rlbp1 Rbp4 Rbp1 Dhrs4 Dhrs3 Rdh8 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis Hsd17b3 Srd5a1 Hsd3b1 Srd5a2 Akr1c18 Cyp17a1 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis Impdh2 Impdh1 Gmps Nme3 Nme2 Nme1 Nme7 Nme6 Guk1 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis Rdh11 Rdh12 Rdh10 Rbp2 Dhrs9 Lrat Ces4a Ces5a Pnlip Lipc Ces2h Ces1d Bco1 Rbp4 Rbp1 Dhrs4 Dhrs3 Rdh8 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis Ephx3 Gpx4 Alox12 Alox5 Cyp2d4 Ptgs2 Alox15 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis Pik3r2 Pik3r3 Pik3r4 Pi4kb Cdipt Pik3cg Pik3cb Pik3cd Pikfyve Pi4k2b Pik3c3 Pik3c2b Pik3c2a Pik3c2g Sacm1l Fig4 Pi4k2a Pip5k1c Pip5k1b Pik3r5 Pik3r6 Pip4k2b Pik3r1 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Gale Hk3 Gnpnat1 Uap1 Gnpda2 Gpi Pgm3 Gck Hk2 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I Abat CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Cdo1 Got1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis Acot2 Acsbg2 Acot3 Hsd17b12 Elovl6 Acsl1 Elovl7 Acot7 Acsbg1 Slc27a2 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation Abat TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation Hoga1 Prodh2 Got2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation Cyp4f4 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) Fads2 Elovl5 Hsd17b12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis Lss SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Sgpp1 Acsbg2 Acer1 Acer2 Asah2 Acsl1 Asah1 Acsbg1 Sphk2 Sphk1 Ptgr1 Slc27a2 Sgpp2 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Ada Pgm2 Pnp PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation Tymp Cda Upp1 Upp2 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Pip4k2a Plch2 Plcd1 Plcd4 Plcd3 Plcb4 Plcb3 Pip4p2 Pip4p1 Plcz1 Plcb2 Plce1 Plcb1 Mtmr3 Plcg1 Plcg2 Mtmr14 Pip4k2c ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis Akr1c1 Akr1c2 Srd5a1 Srd5a2 Akr1c18 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I Mthfd1l Shmt2 Shmt1 Mthfd2l Aldh1l2 Mthfd1 Mthfd2 Mthfs Mthfr Mtr GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation Gk5 Gk Gk2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation Mpi L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation Ahcy Mat2a Mat1a ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III Ada Hprt1 Pnp REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation Sod3 Sod2 Sod1 Gpx1 Gpx3 Gpx6 Gpx5 Gpx7 Cat Gpx8 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation Nt5e Nt5c3a Ada Pnp Xdh Nt5c1a ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) Cyp2e1 Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Akr1b10 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis Tmlhe Bbox1 Aldh9a1 Shmt1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Inpp5d Itpka Synj1 Inpp5a Itpkc Itpkb Ippk Ipmk Itpk1 Inpp5k Synj2 Inppl1 LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis Gpx4 Alox12 Alox5 Alox15b Alox15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation Lipg Dagla Lipe Lipf Lpl Pnpla3 Cel Daglb Pnliprp2 Pnpla2 Pnlip Lipc CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Gne Nanp Nans Cmas CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis Pgs1 Ptpmt1 Crls1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation Comt CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis Gamt Gatm UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) Ugdh GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis Rrm2 Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis Pfkfb4 Pfkfb3 Tigar Pfkfb2 Pfkfb1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis Ggps1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) Shmt2 Tyms ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis Rrm2 Rrm2b Nme3 Nme2 Nme1 Nme7 Nme6 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Nmnat1 Qprt Nadsyn1 Nmnat2 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I Rnmt Rngtt DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis Cbr1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I Ptdss1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) Fads2 Elovl5 Hsd17b12 Elovl7 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) St8sia2 Gcnt3 Gcnt2 B3gnt2 B4galt1 B4galt2 B4galt3 St6gal2 St6gal1 St3gal4 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III Acss1 Cyp2e1 Aldh3a2 Acss3 Aldh2 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II Acss1 Aldh3a2 Acss3 Aldh2 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation Bckdhb Bckdha Dbt Dld Pccb LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III Glb1l3 Glb1 Lct NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV Aox1 Cyp4x1 Fmo3 Cyp2a3 Cyp2u1 Fmo2 Cyp2s1 Fmo5 Fmo4 Ugt1a5 Ugt2b34l1 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) Gale Galt Pgm1 Galm Pgm2 Galk1 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Hk3 Gnpnat1 Uap1 Gpi Pgm3 Gck Hk2 Gfpt1 Gfpt2 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis Gpt INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis Paics Adsl Atic L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) Aldh7a1 Dhtkd1 Aadat Aass L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis Sars2 Sars1 Sephs1 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation Hacl1 Phyh Aldh3a2 Slc27a2 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Ggps1 Fdps THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis Lcmt2 Tyw3 Tyw1 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I Plaat1 Plaat5 Napepld Pla2g1b Enpp2 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation Echs1 Acadsb Acat1 Acat2 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis Kmo Ido2 Nmnat1 Qprt Nadsyn1 Ido1 Nmnat2 Tdo2 Haao Kynu LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation Acsbg2 Acsl3 Acsl1 Acsbg1 Slc27a2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) Tst 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis Plcb1 Dagla Ddhd1 Daglb ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) Hemk2 Slc20a2 Slc20a1 Trmt112 Aqp9 Slc34a2 Pnp Aqp7 Slc2a1 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation Cyp4x1 Cyp2a3 Cyp2u1 Cyp2s1 Cyp2b2 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I Pgm1 Pgm2 Ugp2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis Alox5 Lta4h Ptgs2 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis Aldh18a1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation Papss2 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis Gmppa Pmm2 Pmm1 Gpi Mpi CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Sqle Ebp Dhcr24 Sc5d Kcnh7 Tm7sf2 Dhcr7 Hsd17b7 Fdft1 Nsdhl Lss Lbr UREA CYCLE%BIOCYC%PWY-4984 urea cycle Asl Cps1 Ass1 Otc GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) Shmt2 Dmgdh Shmt1 Bhmt SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) Tst Suox HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis Alad Alas2 Hmbs Uros Fech Cpox Urod Ppox PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I Pccb L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation Bckdhb Bckdha Sdsl Dbt Dld Sds GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage Hprt1 Pnp CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle Asl Ass1 Nos3 Nos2 Nos1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation Cbs Cth Bckdhb Bckdha Dbt Suox Dld Mat2a Pccb Mat1a Ahcy Cdo1 Bhmt Bhmt2 Mtr Got1 TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis Alad Alas2 Hmbs Uros MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway Pmvk Hmgcr Mvd Hmgcs2 Acat1 Acat2 Idi1 Hmgcs1 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II Fmo1 Ado ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) Gsto1 Glrx DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis Gpat4 Plpp4 Lpcat3 Mogat1 Gpat2 Gpat3 Plpp2 Lpcat4 Plpp3 Plpp1 Agpat5 Dgat2 Gpam Plppr4 Abhd5 Dgat1 Mboat2 Plppr2 Agpat3 Plppr3 Lclat1 Agpat4 Agpat2 Agpat1 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Ipmk Itpk1 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis Ddc Th Dbh 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis Tyw3 Tyw1 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I Csad Fmo1 Cdo1 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I Aprt MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle Mdh1 Mdh2 Got1 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Il4 Cabin1 Pou2f1 Ifng Cd40lg Akap5 Faslg Csf2 Junb Nfatc3 Nfatc2 Ptgs2 Fosl1 Jun Chp1 Rcan2 Fkbp1a Il2ra Prkaca Fos Batf3 Il2 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Tfe3 Dcp1a Rbl1 Foxh1 Irf7 Gata3 Serpine1 Skil Med15 Atf3 Dlx1 Nr3c1 Myod1 Max Snip1 Cebpb Ar Ncoa2 Ncoa1 Il5 Sp1 Gsc Sap18 Cited1 Sp3 Runx3 Runx1 Runx2 Kat2a Cbfb Vdr Rbbp7 Esr1 Hspa8 Crebbp Smad2 Smad3 Mef2c Smad4 Zbtb17 Cdk4 Cdk2 Lamc1 Tcf3 Cdkn1a E2f5 Smad7 Jun Fos Atf2 Il10 Hnf4a Nkx2-5 Pias3 Tgif1 Hdac2 Pias4 Ifnb1 Ctbp1 Myc Hdac1 Foxg1 Akt1 Foxo4 Cdkn2b Foxo3 Foxo1 Creb1 Col1a2 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Il23a Il17a Nfkbia Rela Stat5a Il18r1 Il1b Stat3 Stat1 Pik3r1 Alox12b Il2 Ifng Socs3 Stat4 Il18 Il12b Tnf Il6 Cd4 Ccl12 Cxcl9 Itga3 Il23r Nfkb1 Jak2 Cxcl3 Nos2 Il24 Il17f SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Ran Pias1 Pias2 Hdac1 Ranbp2 Xpo1 Hdac4 Ube2i Mdm2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Nfkbia Rela Pik3r1 Mapk8 Mapk1 Ilk Itgav Mapk3 Jun Rhoa Bcar1 Spp1 Rac1 Cd44 Vav3 Fos Gsn Syk Mmp2 Ptk2b Mmp9 Map3k1 Plau Rock2 Chuk Map3k14 Nfkb1 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Mapk1 Mapk3 Fkbp1a Smad4 Tgfb1 Tgfb3 Acvrl1 Id1 Arrb2 Ppp1ca Csnk2b Smad7 Cav1 Gdf2 Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Acvr2a Inhba Acvr2b Smad5 Tgfbr1 Tgfbr2 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Rasa1 Irs1 Src Pxn Irs2 Grb10 Pdlim7 Gdnf Ptpn11 Gfra1 Pik3r1 Nck1 Rap1a Gab1 Frs2 Ptk2 Dok1 Dok4 Dok6 Grb2 Mapk8 Prkca Mapk1 Sos1 Crk Hras Mapk3 Jun Rhoa Bcar1 Rac1 Prkaca Ret Grb7 Shank3 Creb1 Shc1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Mapk1 Col11a1 Mapk3 Col11a2 Fgf19 Cask Ccl5 Bsg Prkaca Hpse Ppib Col2a1 Sdcbp Col3a1 Col1a1 Mmp9 Mmp7 Col4a3 Col5a2 Col6a2 Mmp1 Tgfb1 Col4a1 Hgf Col5a1 Col4a5 Fgf23 Fgfr3 Fgfr4 Lama5 Sdc1 Met Col1a2 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Rasa1 Rras Prkce Rasgrp3 Rasgrp4 Rasgrp1 Rasgrp2 Rin1 Grb2 Prkca Sos1 Hras Rasa2 Rabgef1 Camk2b Nf1 Rasal1 Dab2ip Kras Prkcz Plce1 Lgals1 Lgals3 Rasgrf2 Nras Prkcb AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Incenp Aurkc Aurkb IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Irs1 Irs2 Cebpb Grb2 Il5 Sp1 Col1a1 Socs3 Jak2 Stat5a Pik3r1 Spi1 Stat6 Alox15 Socs5 Ets1 Jak3 Aicda Jak1 Fcer2 Il13ra1 Il13ra2 Arg1 Bcl2l1 Mybl1 Irf4 Oprm1 Tff3 Lta Inpp5d Ptpn6 Thy1 Cbl Ccl17 Il4 Mtor Selp Ccl11 Cd40lg Rps6kb1 Pigr Egr2 Parp14 Mapk14 Il4r Il2rg Stat5b Bcl6 Il10 Fes Hmga1 Retnlg Akt1 Col1a2 Shc1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Rela Ptpn11 Pik3r1 Jak3 Jak1 Grb2 Sos1 Bcl2l1 Il2ra Rac1 Il2 Mtor Rps6kb1 Il2rg Smpd1 Eif3a Hsp90aa1 Sgms1 Rps6 Gab2 Myc Tert Lck Bcl2 Akt1 Prkcz E2f1 Nfkb1 Ugcg Foxo3 Shc1 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Frs3 Irs1 Egfr Gnai1 Raf1 Gnai3 Il6st Sdc2 Ntf4 Ntf3 Ptpn11 Pdgfrb Ifngr1 Vegfa Gab1 Pdgfb Frs2 Il6r Arhgap35 Nos3 Egf Igf1 Ntrk2 Grb2 Map2k2 Sos1 Ntrk1 Map2k1 Ntrk3 Hras Igf1r Il6 Kras Jak2 Nras Stat1 Pik3r1 Jak3 Jak1 Rhoa Il2ra Prkaca Il2 Ifng Il2rg Gab2 Lck Bdnf Afdn Angpt1 Lmo4 Ngf Shc1 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Stat3 Myod1 Ar Ncoa1 Neurog3 Bglap Arnt Ptf1a Runx2 Ghr Camk2d Hif1a Hey2 Maml1 Maml2 Parp1 Crebbp Hes1 Twist1 Ascl1 Rb1 Hes6 Tle1 Gaa Kdm1a Rbbp8 Tcf3 Yy1 Notch1 Gata6 Gata4 Gata1 Cdkn1b Cd4 Ctbp1 Hdac1 E2f1 Jak2 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itgb4 Itga1 Itgb2 Itga2 Itgal Itga10 Itgad Itgb8 Itga7 Itga8 Itgav Itgax Itgb6 Itga3 Itga5 Itgb7 Itga6 Itga9 Itgb1 Itga2b Itgam PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Golga2 Nudc Bora Incenp Kif2a Kif20a Fbxo5 Spc24 Ercc6l Fzr1 Pak1 Ppp1r12a Ect2 Bub1 Tubg1 Cdc14b Cdc20 Ppp2ca Ppp1cb Ccnb1 Rhoa Plk1 Gorasp1 Clspn Fbxw11 Stag2 Cenpu Tpx2 Sgo1 Rab1a Ppp2r1a Wee1 Prc1 Cdk1 Rock2 Btrc Ninl Cdc25c Kiz Tpt1 Aurka Cdc25b Ndc80 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Ube2d3 Xrcc5 Atm Atr Ube2l3 Cdk2 Rbbp8 Ccne1 Cstf1 Bard1 Mre11 Fancl Prkdc Fancc Nbn Tp53 Fancf Fancg Rad51 Rad50 Fancd2 Pcna Ewsr1 Topbp1 Xrcc6 Brca1 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Gnai1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Rhoa S1pr5 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Src Stat5a Pik3r1 Camk4 Ywhah Ywhag Gab1 Ywhae Epb41l1 Pdpk1 Camk2a Ywhab Trpc3 Grb2 Trpv1 Sfn Ntrk1 Sos1 Egr1 Bad Hras Ccnd1 Plcg1 Gsk3b Prkcd Ywhaz Kras Akt1 Foxo3 Creb1 Nras Shc1 Ngf IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Il18r1 Stat3 Pias2 Mapk8 Jun Il2ra Mapk9 Il13 Fos Cd3g Cd247 Il2 Prf1 Cd3d Cd28 Crebbp Ifng RT1-Da Cd86 Cd80 Tbx21 RT1-Db1 Tgfb1 Etv5 Irf1 Stat4 Il18 Cd4 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Rasa1 Cul3 Klhl13 Vim Kif23 Incenp Aurkc Kif20a Aurkb Bub1 Rhoa Sgo1 Psma3 Aurka Cenpa Klhl9 Ndc80 Stmn1 Kif2c Ppp2r5d Smc4 Smc2 Ncapg Ncaph Ppp1cc Cbx5 Npm1 Cdca8 Racgap1 Ncapd2 Septin1 Tacc1 Mylk Des Nsun2 Pebp1 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Src Pitpna Ntn1 Dock1 Elmo1 Fyn Yes1 Pik3r1 Nck1 Trio Dcc Map1b Dapk1 Pak1 Ptk2 Unc5b Myo10 Camk2a Unc5a Unc5c Map2k2 Mapk1 Map2k1 Mapk3 Rhoa Plcg1 Bcar1 Rac1 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gna13 Gnai1 Mapk1 Gnai3 Gna12 Gnaz Gnao1 Mapk3 Gnai2 Plcg1 Rhoa S1pr5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Pde3b Mapk1 Pik3r6 Map2k1 Pik3cg C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Myf6 Tab2 Hipk2 Ada Gata3 Myod1 Cebpb Sp1 Hras Ccnd1 Hspa8 Crebbp Hes1 Cdkn1a Gata1 Cdkn1b Cd4 Kras Nras Spi1 Ets1 Ube2i Adora2b Ccna1 Ccnb1 Slc25a3 Birc3 Prtn3 Map3k7 Ets2 Clta Tfec Pim1 Tom1 Cdkn2a Rag2 Atp2b1 Snd1 Maf Ptcra Kit Smarca2 Mcm4 Cd34 Ptgs2 Lef1 Mat2a Trim28 Nlk Cebpa Pias3 Elane Csf1r Gstm2 Yeats4 Wnt1 H2az1 Myc Ppp3ca Kitlg Cbx4 Bcl2 Casp6 Anpep Mad1l1 Ca1 Zfhx3 Cdk6 Col1a2 Lect2 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Rasa1 Rras Src Pxn Ephb1 Ephb2 Ephb3 Tf Efnb1 Efnb2 Pik3r1 Nck1 Efnb3 Rap1a Rap1b Synj1 Dnm1 Pak1 Ptk2 Itsn1 Rock1 Kalrn Efna5 Grb2 Mapk1 Map2k1 Crk Hras Mapk3 Rac1 Kras Grb7 Nras Shc1 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Src Pik3r1 Pdpk1 Ikbkb Mapk8 Birc2 Ikbkg Map2k7 Map2k6 Cltc Cflar Birc3 Faim2 Bid Pik3cb Mapk9 Casp8 Rfc1 Casp3 Syk Ripk1 Btk Fas Fadd Map3k1 Ezr Mapk10 Mapk11 Faslg Chuk Mapk14 Smpd1 Akt1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Nfkbia Rela Raf1 Egf Igf1 Mapk8 Map2k2 Mapk1 Map2k1 Bad Mapk3 Birc3 Bid Prkcd Casp8 Ripk1 Fadd Map3k1 Rb1 Smpd3 Ctsd Aifm1 Eif2ak2 Pawr Nsmaf Madd Asah1 Smpd1 Tnfrsf1a Bag4 Cradd Tnf Pdgfa Traf2 Prkra Myc Cycs Map2k4 Sphk2 Bcl2 Akt1 Prkcz Bax Nfkb1 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Th Tor1a Src Grk5 Sncaip Slc6a3 Ube2l3 Lyn Prkn Uchl1 Fyn Maob Yes1 Fgr Hck Park7 Snca Bad Fkbp1a Prkcd Syk Ptk2b Ppp2r5d Lck Blk Csnk2a1 Pld1 Plcb2 Klk6 Pld2 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Ikbkb Src Nfkbia Rela Btrc Lck Mapk14 Pik3r1 Nfkb1 Arrb2 Rel Syk RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Srf Ppp1r12a Ccn1 Rock1 Slc9a1 Acta1 Mapk12 Mapk8 Slc9a3 Diaph1 Rdx Map2k6 Cfl1 Jun Msn Rhoa Pten Cit Map2k3 Myl2 Limk1 Fos Limk2 Pkn2 Pkn1 Sh3gl2 Tln1 Pip5k1c Ezr Pip5k1b F2rl2 Rock2 Vcl Scai Atf2 Cdkn1b Map2k4 Prkcz Pld1 Itgb1 Pld2 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Irs1 Egfr Src Pdgfrb Pdgfb Dok1 Egf Grb2 Crk Socs3 Blk Jak2 Itga2b Stat5a Lyn Stat3 Fyn Fgr Pik3r1 Yes1 Hck Rhoa Bcar1 Ins2 Prl Ybx1 Prlr Cdh2 Stat5b Csn2 Csf1 Insr Trpv6 Cav1 Txn Ptpn1 Csf1r Csk Fcgr2a Capn1 Spry2 Fer Lck Lep Nox4 Akt1 Lat Lepr Shc1 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Rasa1 Epb41 Lama1 Src Lama3 Itga2 Ephb2 Sdc2 Mapk8 Mapk1 Hras Mapk3 Rhoa Fgf19 Cask Prkcd Prkaca Casp3 Sdcbp Mmp2 Ezr Csf2 Tgfb1 Fgf23 Fgfr3 Fgfr4 Nf1 Bax Fn1 Kng2l1 Cav2 Itgb1 Trappc4 Rack1 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Ptpn7 Raf1 Braf Map3k8 Elk1 Prkca Mapk1 Map2k1 Hras Mapk3 Kras Fos Nras Prkcb ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Hrk Ccna2 Serpinb5 Atf3 Kat5 Macroh2a1 Col24a1 Jdp2 Ruvbl2 Jund Csrp2 Gadd45a Sele Prkca Dusp5 Tgfb2 Dusp1 Pdgfra Dusp10 Ccnd1 Dusp8 Hbg1 Ppargc1a Mapk9 Cbfb Esr1 Hes1 Mapk11 Rb1 Cdk4 Socs3 Il6 Nf1 Nos2 Th Il23a Cul3 Mapk8 Mapk1 Arg1 Bcl2l1 Mapk3 Jun Fos Mmp2 Pou2f1 Ifng Plau Ins2 Mapk14 Junb Atf2 Bcl2 Creb1 Brca1 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Src Lyn Fyn Yes1 Fgr Hck Rock1 Efna5 Pik3r6 Pik3cg Crk Rhoa Plcg1 Efna1 Efna2 Efna3 Vav3 Arhgef15 Cbl Crkl Ngef Epha1 Epha2 Vav2 Epha3 Epha4 Epha6 Epha7 Cdk5 Epha8 Lck Blk SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Sirt5 Sirt4 Nfkbia Rela Stat3 Ranbp2 Xpo1 Max Hdac4 Ube2i Ran Sap18 Prkaca Rbbp7 Crebbp Btrc Nr2c1 Hdac3 Hdac11 Yy1 Hdac10 Hdac7 Smad7 Mta2 Tnfrsf1a Hdac8 Gata1 Mbd3 Hdac2 Mbd2 Tnf Pparg Chd3 Chd4 Sirt3 Hdac1 Sirt2 Sirt1 Smurf1 Nfkb1 Gatad2a Mxd1 Wdr77 Sirt6 Gatad2b Gata2 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Itga1 Ctnnb1 Klc1 Itga2 Tshr Cdh1 Slc2a4 Adrb2 Scamp2 Rala Acap1 Exoc3 Agtr1 Ctnna1 Exoc5 Exoc6 Vamp3 Nme1 Exoc2 Dnm2 Avpr2 Spag9 Itgav Exoc7 Cltc Bin1 Ctnnd1 Mapk8ip3 Arf6 Pip5k1c Ins2 Itga10 Itga7 Itga8 Itga3 Itga5 Itga6 Pld1 Itga9 Itgb1 Pld2 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Ctnnb1 Rala Ywhah Ywhag Xpo1 Ywhae Ran Gadd45a Ywhab Ikbkb Mapk8 Sfn Ccnb1 Plk1 Csnk1a1 Ywhaz Mapk9 Csnk1g3 Csnk1g1 Bcl2l11 Csnk1g2 Zfand5 Skp2 Fbxo32 Crebbp Ralb Mst1 Mapk10 Sod2 Usp7 Faslg Chuk G6pc1 Rbl2 Cdk2 Cat Csnk1d Sgk1 Bcl6 Csnk1e Cdkn1b Sirt1 Akt1 Foxo4 Foxo3 Foxo1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Gnai1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Gna11 Sgpl1 Gna15 Gna14 Abcc1 Gna13 Gnaq Sphk1 S1pr1 S1pr3 S1pr2 Sgpp1 Sphk2 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Src Raf1 Slc2a4 Ywhah Ywhag Ywhae Pdpk1 Ywhab Sfn Bad Bcl2l1 Gsk3b Ywhaz Prkaca Mtor Chuk Cdkn1a Cdkn1b Hsp90aa1 Prkdc Rictor Akt3 Akt1 Akt2 Foxo4 Casp9 Foxo3 Kpna1 Foxo1 Mapkap1 Gsk3a Mlst8 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Tiam1 Enah Src Ctnnb1 Nckap1 Klhl20 Ap1m1 Cdh1 Wasf2 Jup Cttn Tjp1 Dlg1 Pik3r1 Abi1 Rap1a Rap1b Ctnna1 Nme1 Crk Ccnd1 Rhoa Ctnnd1 Arf6 Rac1 Pip5k1c Vav2 Akt1 Itgb7 Afdn SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Pik3r1 Stil Dhh Arrb2 Hhip Ihh Lrp2 Gli2 Shh Grk2 Lrpap1 Tgfb2 Smo Ptch1 Boc Pthlh Cdon Akt1 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk4 Plk2 Plk1 Plk3 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Nckap1 Wasf2 Abi1 Crk Map2k7 Map2k6 Ncf1 Ncf2 Mapk9 Brk1 Arhgdia Noxa1 Baiap2 Iqgap3 Arpc1b Actr2 Actr3 Arhgap5 Pak2 Wasf1 Arpc3 Noxo1 Arpc2 Cyba Abi2 Cybb Arpc5 Arpc4 Map3k11 Map2k4 Racgap1 Plcb2 Ctnnb1 Stat5a Cdh1 Stat3 Ctnna1 Pak1 Mapk8 Cfl1 Jun Bcar1 Map2k3 Rac1 Limk1 Pip5k1c Map3k1 Pip5k1b Mapk14 Atf2 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Guca1a Rgs9 Lrat Gucy2f Gngt2 Gnat2 Rdh12 Slc24a2 Rgs9bp Pde6c Cnga3 Arr3 Cngb3 Grk1 Gucy2e Rpe65 Pde6h Gnb3 Guca1b Gnb5 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Arhgef7 Mcf2l Arhgef6 Spata13 Arhgef9 Fgd1 Git1 Dnmbp Mcf2 Arhgap17 Dock11 Itsn1 Ralbp1 Bcar3 Nme1 Arhgef25 Farp2 Dock6 Arhgap1 Apc Itsn2 Plcg1 Arhgdia Vav3 Ngef Vav2 Racgap1 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Elk1 Serpine1 Vegfa Ets1 Sp1 Adora2a Epo Eif3e Arnt Bhlhe40 Efna1 Hif1an Egln2 Egln3 Epas1 Cited2 Pgk1 Slc2a1 Vhl Crebbp Pou5f1 Twist1 Slc11a2 Mmp14 Apex1 Abcg2 Eloc Fxn Sirt1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Src Kat5 Nr3c1 Rel Mdm2 Ar Ncoa2 Ncoa1 Mapk8 Egr1 Map2k6 Jun Gsk3b Pkn1 Pou2f1 Crebbp Mapk14 Smarca2 Nr2c2 Nr2c1 Hoxb13 Carm1 Dnaja1 Zmiz2 Hdac7 Trim24 Cebpa Appbp2 Pde9a Hsp90aa1 Kat7 Nr0b1 Spdef Rxrb Rxra Hdac1 Map2k4 Smarce1 Ehmt2 Sirt1 Smarcc1 Rxrg Senp1 Tmprss2 Foxo1 Rchy1 Rack1 Gata2 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Elk1 Pik3r1 Srf Cav1 Jak1 Grb2 Sos1 Crk Itgav Pdgfra Jun Plcg1 Csnk2a1 Fos Cav3 Shc1 Crkl Shf SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Ncstn Aph1b Egfr Src Ncan Sdc3 Ptn Mc4r Psenen Cttn Pomc Psen1 Fyn Agrp Fgf23 Fgfr3 Fgfr4 Fgf19 Cask SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Atf1 Gdi1 Eif4ebp1 Pla2g4a Mitf Cebpb Rab5a Elk4 Slc9a1 Hspb1 Usf1 Mapkapk3 Mapkapk2 Krt8 Eif4e Jun Mapkapk5 Rps6ka5 Hbp1 Ppargc1a Mknk1 Atf6 Esr1 Mef2c Mapk11 Mapk14 Ptgs2 Atf2 Tp53 Nos2 Creb1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Src Pxn Dock1 Git1 Abi1 Ptk2 Crk Bcar1 Spp1 Arf6 Rac1 Ywhaz Prkar1b Prkaca Mdk Jaml Jam2 Cd81 Ptpra Ptk2b Tln1 Prkacb Adam28 Myh2 Vcam1 Igsf8 Cd14 Thbs2 Fn1 Itgb1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Dkk1 Ror2 Atp6ap2 Lrp6 Lrp5 Igfbp4 Wnt5a Wif1 Wnt7b Wnt3a Wnt7a Wnt2 Wnt3 Wnt1 Fzd1 Cthrc1 Fzd2 Kremen2 Fzd5 Fzd4 Ryk Fzd6 Kremen1 Fzd9 Rspo1 Fzd8 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Atf3 Nr3c1 Jund Il5 Sp1 Dusp1 Egr1 Ccnd1 Cbfb Hif1a Esr1 Mmp1 Cdkn1b Il6 Ccl12 Gata2 Th Dmp1 Ctnnb1 Gja1 Edn1 Elf1 Penk Dmtf1 Mt2 Nts Mafg Bag1 Tcf7l2 Cops5 Ets1 Fabp4 Ccn1 Timp1 Agt Acta1 Nppa Fosl1 Jun Pten Fos Bcl2l11 Il2 Il4 Cdkn2a Mmp9 Ifng Plau Cdk1 Maf Csf2 Tgfb1 Junb Nfatc3 Nfatc2 Atf2 Il10 Tp53 Myc Creb1 Col1a2 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Sdcbp Stat5a Lyn Ptpn11 Pik3r1 Stat5b Csf2rb Grb2 Il5 Il5ra Cish Jak2 Pim1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Ctnnb1 Pxn Arhgef7 Arhgef6 Xpo1 Ruvbl2 Ppp1r12a Diaph1 Ilkap Ilk Ruvbl1 Rhog Jun Ccnd1 Ppp1r14a Ppp1r14c Gsk3b Ppp1r14b Naca Rac1 Elmo2 Nck2 Tns1 Git2 Parvg Tacc3 Parp1 Snai1 Lims2 Zeb1 Actn1 Parvb Zyx Cdc37 Parva Ckap5 Aurka Myl9 Hsp90aa1 Rictor Akt1 Creb1 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Ctnnb1 Gja1 Jup Cttn Ptpn11 Pik3r1 Ctnna1 Rock1 Mapk8 Rhoa Plcg1 Ctnnd1 Rac1 Myl2 Gsn Pip5k1c Lrp5 Cdh2 Daglb Camk2g Mapre1 Dctn1 Gap43 Ptpn1 Kif5b Cnr1 Fgfr1 Gria2 Dagla Fer Axin1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Abca1 Fam120b Rara Srebf1 Rps6kb1 Nr4a1 Tgfb1 Ncoa1 Pparg Tnf Rxrb Rxra Med1 Rarg Bcl2 Thrb Thra Rxrg Nr1h4 Nr1h3 Nr1h2 Vdr Ppard Ppara P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Tp63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Col18a1 Mpg Nrip1 Sra1 Apbb1 Ebag9 Phb2 Pdia2 Anp32a Ap1b1 Cebpb Pou4f1 Lcor Ncoa2 Pou4f2 Ncoa1 Nr0b2 Cd82 Dscam Pgr Axin2 Ccnd1 Tff1 Setsip Ncoa7 Atp5pf C3 Mta1 Hsf2 Xbp1 Esr1 Sod1 Esr2 Ndufv3 Abca3 Prdm15 Calcoco1 Smad4 Uba3 Nedd8 Ctsd Stat5a Hdac4 Jun Chuk Prl Nr0b1 Myc Hdac1 Med1 Pcna Lmo4 Brca1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Rasa1 Pxn Rela Stat5a Elf1 Elk1 Ptpn11 Fyn Pik3r1 Nck1 Agtr1 Ets1 Pak1 Ptk2 Nos3 Grb2 Mapk8 Mapk1 Crk Mapk3 Rac1 Mmp2 Rps6kb1 Tnip2 Mapk14 Grb14 Plg Fgf2 Stat5b Angpt2 Cdkn1a Angpt4 Fes F2 Bmx Elf2 Tnf Itga5 Akt1 Nfkb1 Fn1 Grb7 Angpt1 Foxo1 Itgb1 Shc1 Pld2 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Prkce Ptpn7 Raf1 Braf Elk1 Mapk8 Map2k2 Prkca Mapk1 Egr1 Map2k1 Fosl1 Hras Mapk3 Jun Il2ra Mapk9 Fos Cd3g Cd247 Il2 Prf1 Cd3d Ifng Faslg Junb Nfatc3 Nfatc2 Il2rg Stat4 Tnfrsf4 Ifnar1 Tnf Eomes Egr4 Prkcq Tnfrsf9 Cd8b Kras Cd8a Ifna1l1 B2m Nras Prkcb SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Rasa1 Src Raf1 Pxn Braf Nck1 Rap1a Rap1b Arhgap35 Ptk2 Grb2 Sos1 Crk Map2k1 Ccnd1 Plcg1 Mapk9 Bmx Map2k4 Itga5 Arhgef11 Asap1 Itgb1 Arhgef28 Arhgap26 Capn2 Rras Ptpn21 Arhgef7 Dock1 Elmo1 Fyn Pik3r1 Yes1 Ets1 Pak1 Acta1 Mapk8 Mapk1 Itgav Jun Rhoa Bcar1 Mapk8ip3 Rac1 Nck2 Git2 Tln1 Actn1 Vcl Rock2 Grb7 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Itgb4 Lama1 Lamb2 Lamb3 Lama3 Lamb1 Lamc1 Itga6 Lama5 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Atm Atr H2ax Ube2t Blm Chek1 Wdr48 Usp1 Fancb Palb2 Rfc5 Rfc3 Faap100 Rfc4 Rfc2 Rmi1 Hus1 Rpa2 Rad17 Atrip Brip1 Brca2 Rad1 Faap24 Fan1 Fbxw11 Hes1 Btrc Mre11 Fancl Fancc Nbn Fancf Fancg Rad50 Fancd2 Topbp1 Brca1 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Atm Ada Tp63 Mdm2 Sfn Brca2 Gsk3b Hbp1 Runx1 Dlx5 Dlx6 Bdkrb2 Ppp2r5a Vdr Igfbp3 Hells Sec14l2 Cdkn2a Itch Stxbp4 Hes1 Tcf7l1 Ccnb2 Rrad Krt14 Wwp1 Rab38 Col5a1 Nrg1 Tbxt Adrm1 Il1a Notch1 Axl Perp Mre11 Itga3 Rack1 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Sptan1 Apaf1 Diablo Vim Top1 Srebf1 Dffa Dffb Ptk2 Acta1 Birc2 Birc3 Bid Casp8 Limk1 Gsn Casp3 Ripk1 Prf1 Parp1 Map3k1 Madd App Tnfrsf1a Arhgdib Tfap2a Cradd Tnf Slk Numa1 Traf2 Lmnb1 Lmnb2 Cycs Pidd1 Casp7 Bcl2 Krt18 Casp6 Bax Casp4 Casp9 Cfl2 Xiap Satb1 Casp2 Casp1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Tiam1 Arhgef7 Arhgef6 Arhgef2 Dock1 Spata13 Dock2 Elmo1 Abr Eps8 Rap1gds1 Trio Abi1 Prex1 Prex2 Mcf2 Arhgap17 Vav1 Bcr Ralbp1 Arhgap9 Kalrn Arhgef25 Dock6 Arhgap1 Sos1 Rac1 Arhgdia Vav3 Ngef Vav2 Racgap1 Rasgrf2 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Itgb2 Hck Rap1a Rap1b Rock1 Lrp1 Selplg Ccn2 Jam3 Plat Ager Icam1 Mst1r Rhoa Apob Thy1 Jam2 Mmp2 Tln1 Selp Mmp9 Mst1 Myh2 Plau Plg Tnf Il6 Nfkb1 Itgam ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Tiam1 Kalrn Nme1 Mapk1 Mapk3 Rhoa Arf1 Rab11fip3 Arf6 Rac1 Rab11a Pld1 Pld2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Rasa1 Raf1 Pxn Ptpn11 Pla2g4a Vav1 Ptk2 Dok1 Ikbkb Grb2 Map2k2 Ikbkg Sos1 Map2k7 Dusp1 Map2k1 Hras Plcg1 Itk Fcer1a Plpp1 Klrg1 Hcls1 Btk Cblb Wipf1 Lat2 Lcp2 Pak2 Ptpn13 Pla2g1b Ms4a2 Fcgr2b Map2k4 Nfkb1 Prkcb Pld2 Rela Lyn Fyn Pik3r1 Mapk8 Mapk1 Mapk3 Jun Inpp5d Fos Syk Cbl Map3k1 Chuk Nfatc2 Sphk1 S1pr1 Gab2 Fer Akt1 Lat Shc1 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Src Gnai1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Pdgfrb Cxcr4 Vegfa Pdgfb Gna11 Gna15 Gna14 Gna13 Gnaq Mapk1 S1pr3 Mapk3 Rhoa Akt3 Akt1 Rac1 Jak2 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Pxn Vcam1 Rhoa Madcam1 Itgb7 Itgb1 Ptk2 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Tiam1 Frs3 Rasa1 Ntf4 Ntf3 Ptpn11 Rap1a Rap1b Gab1 Frs2 Dnm1 Ntrk2 Grb2 Sos1 Ntrk1 Crk Map2k1 Ntrk3 Hras Ccnd1 Plcg1 Crkl Matk Sqstm1 Faim Prkci Maged1 Dnaja3 Ngfr Shc3 Shc2 Gipc1 Rgs19 Dynlt1 Nedd4l Abl1 Kras Prkcz Arhgap32 Rit1 Rit2 Ehd4 Nras Mcf2l Dock1 Elmo1 Stat3 Pik3r1 Mapk1 Rhog Mapk3 Rhoa Rac1 Gab2 Bdnf Ngf Shc1 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Cyth1 Dapp1 Src Inppl1 Plekha1 Plcg2 Lyn Blnk Adap1 Arf5 Fyn Yes1 Fgr Pik3r1 Hck Rap1a Pdpk1 Pik3r6 Pik3cg Hras Rhoa Plcg1 Pten Arf1 Arf6 Rac1 Pik3cb Inpp5d Itk Syk Btk Sgk1 Hsp90aa1 Lck Kras Lat Blk Foxo3 Cyth2 Zap70 Nras Cyth3 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Tab2 Stat5a Wwox Fyn Erbb2 Pik3r1 Erbb4 Nedd4 Lrig1 Adam17 Ereg Hbegf Mdm2 Nrg2 Btc Cbfa2t3 Grb2 Nrg4 Mapk1 Nrg3 Dlg4 Grin2b Mapk3 Pik3cb Itch Prl Wwp1 Prlr Nrg1 Stat5b Jak2 Shc1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Raf1 Stat5a Lyn Stat3 Ptpn11 Stat1 Pik3r1 Ikbkb Csf2rb Grb2 Map2k2 Mapk1 Cish Sos1 Map2k1 Hras Mapk3 Osm Irf8 Ywhaz Inpp5d Prkaca Fos Pim1 Syk Prkacb Csf2 Stat5b Gab2 Ccl12 Kras Jak2 Nras Shc1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Mapk12 Map2k6 Ccnd1 Mapk13 Map2k3 Eef2k Snta1 Stmn1 Pkn1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Enah Egfr Ctnnb1 Nckap1 Cdh1 Git1 Nck1 Abi1 Exoc3 Ctnna1 Rock1 Egf Igf1 Diaph1 Igf1r Rhoa Ctnnd1 Arf6 Efna1 Myl2 Lima1 Vasp Aqp5 Kifc3 Mgat3 Aqp3 Lpp Epha2 Pip5k1c Nectin2 Myo6 Stx4 Actn1 Vcl Zyx Hgf Met Afdn SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Src Raf1 Pxn Braf Grb10 Ptpn11 Nck1 Vegfa Gab1 Ptk2 Pdpk1 Nos3 Rock1 Grb2 Prkca Map2k2 Mapkapk2 Map2k1 Map2k6 Plcg1 Arf1 Prkcd Pak2 Mapk11 Prkcb Ctnnb1 Fyn Pik3r1 Nedd4 Ctnna1 Dnm2 Mapk1 Itgav Mapk3 Rhoa Map2k3 Fbxw11 Prkaca Nck2 Ptpn6 Cbl Ptk2b Vcl Myof Cdh5 Camkk2 Mapk14 Akap1 Sh2d2a Hsp90ab1 Hgs Ptpn2 Fes Vtn Cav1 Hsp90aa1 Akt1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Eif4g1 Gpam Rpl11 Id2 Eif2s1 Supt7l Pfkm Lin28b Myct1 Ccnd2 Kat5 Tfrc Pdcd10 Hspa4 Max Ireb2 Ruvbl2 Eif4a1 Ubtf E2f3 Eif4e Kat2a Mta1 Crebbp Smad3 Smad4 Cdk4 Npm1 Bax Nme1 Ruvbl1 Fosl1 Ccnb1 Pim1 Slc2a1 Mmp9 Snai1 Hmga1 Riox2 Eno1 Bmi1 Ndufaf2 Hsp90aa1 Bcat1 Ddx18 Nbn Shmt1 Tp53 Myc Hspd1 Tert Prdx3 Cad Nme2 Mtdh Actl6a Cdc25a Serpini1 Odc1 Taf9 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Src Lyn Fyn Rala Yes1 Fgr Hck Pak1 Dusp16 Traf6 Pak3 Map3k3 Dusp1 Map3k12 Map2k6 Dusp10 Dusp8 Map2k3 Rac1 Ripk1 Ralb Pak2 Mapk11 Mapk14 Map2k4 Lck Blk SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Raf1 Stat5a Grb10 Lyn Stat3 Ptpn11 Stat1 Pik3r1 Gab1 Vav1 Mitf Pdpk1 Dok1 Grb2 Mapk8 Map2k2 Sos1 Map2k1 Stap1 Bad Hras Mapk3 Epor Epo Ptpro Pten Grap2 Gsk3b Pik3c2b Sh2b2 Map4k1 Ptpn6 Tec Spred1 Cbl Crkl Spred2 Crebbp Rps6kb1 Kit Matk Fer Kitlg Bcl2 Akt1 Jak2 Foxo3 Shc1 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Bmp4 Shh Fgf7 Gpc3 Mapk8 Furin Ptch1 Mapk9 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Src Pxn Adam2 Adam12 Vcam1 F13a1 Adam15 Csf2 Adam8 Sat1 Kcnj15 Vegfa Vegfd Vegfc Tgm2 Bcar1 Spp1 Fn1 Rac1 Itga9 Nos2 Itgb1 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Xrcc5 Pnkp Polm Nhej1 Dntt Dclre1c Prkdc Aptx Lig4 Aplf Xrcc4 Poll Xrcc6 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Src Raf1 Pxn Ptpn11 Nck1 Rap1a Rap1b Gab1 Eif4ebp1 Ptk2 Pdpk1 Rab5a Grb2 Map2k2 Sos1 Crk Egr1 Map2k1 Eif4e Bad Hras Plcg1 Crkl Pak2 Hgf Prkci Met Map2k4 Rptor Kpnb1 Prkcz Numb Sh3kbp1 Eps15 Rin2 Arhgef4 Pak4 Akt1s1 Muc20 Ctnnb1 Inppl1 Ranbp10 Cdh1 Pik3r1 Ctnna1 Ets1 Pak1 Mapk8 Mapk1 Apc Mapk3 Jun Rhoa Bcar1 Arf6 Rac1 Inpp5d Nck2 Cbl Sh3gl2 Mtor Snai1 Map3k1 F2rl2 Hgs Ptpn2 Ptpn1 Gab2 Akt1 Akt2 Mlst8 Shc1 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Rasa1 Egfr Src Gnai1 Gnai3 Stat3 Ptpn11 Stat1 Pik3r1 Nck1 Gab1 Pak1 Ptk2 Egf Grb2 Mapk1 Sos1 Hras Mapk3 Plcg1 Pik3cb Ptpn6 Nck2 Gsn Tln1 Pip5k1c Ptpn1 Kras Nras Shc1 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Gnai1 Plcb3 F2r Gnai3 Gna12 Arhgef1 Plcb1 Gnaz Gnao1 Trpc6 Grk3 Gnai2 Snx2 Pik3r1 Snx1 Arrb1 Prkcg Dnm1 Gnb1 Nos3 Rock1 Gna13 Dnm2 Prkca Rhoa Prkcd Myl2 Vasp Arhgdia Pkn1 F2rl2 Rock2 Zyx Gna11 F2 Gna15 Gna14 Gnaq Plcb2 Prkcb SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Lama1 Lama3 Cxcl12 Ptk2 Sdc4 Fgf6 Nudt16l1 Tfpi Dnm2 Prkca Rhoa Prkcd Ccl5 Rac1 Mdk Sdcbp Mmp9 Adam12 Actn1 Cxcr4 Plg Fgf2 F2 Fgfr1 Gipc1 Itga5 Fn1 Itgb1 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Rpl11 Atm Hipk2 Atr Ccna2 Kat5 Gsk3b Prkcd Mapk9 Crebbp Nedd8 Cdk2 Yy1 Abl1 Chek1 Mdm2 Mapk8 Smyd2 Cse1l Kat8 Ppp2ca Fbxo11 Kmt5a Dyrk2 Ptpa Rpl23 Ube2d1 Csnk1a1 Csnk1g3 Rassf1 Csnk1g1 Ccng1 Chek2 Csnk1g2 Setd7 Rpl5l1 Cdkn2a Skp2 Ttc5 Pin1 Mdm4 E4f1 Ppm1d Usp7 Daxx Mapk14 Csnk1d Csnk1e Trim28 Tp53 Akt1 Rchy1 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Gata3 Il5 Egr1 Fosl1 Jun Irf4 Il2ra Fos Batf3 Casp3 Il2 Il4 Cblb Pou2f1 Itch Ifng Cd40lg Maf Egr2 Tbx21 Faslg Rnf128 Csf2 Ctla4 Cdk4 Junb Dgka Nfatc3 Slc3a2 Nfatc2 Egr3 Ptgs2 Foxp3 Ptpn1 Tnf Pparg Egr4 Prkcq E2f1 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Ctnnb1 Cdh1 Jup S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Irs1 Gnai1 Gnai3 Gna12 Gnaz Elk1 Gnao1 Cdh5 Mapk14 Gnai2 Gna11 Pak1 Gna15 Gna14 Gna13 Gnaq Mapk8 Mapk1 S1pr2 Jun Mapk3 Rhoa Rac1 Fos NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Src Gnai1 Plcb3 Raf1 Plcg2 Gnai3 Plcb1 Gnaz Gnao1 Gnai2 Pik3r1 Gnb1 Ptk2 Ar Map2k2 Mapk1 Map2k1 Hras Mapk3 Plcg1 Rac1 Fos Gnrh1 Shbg Pelp1 Akt1 Plcb2 Creb1 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Tp53 Cdc25c Plk3 Ccne1 Chek2 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Itgb4 Lama3 Gja1 Dmtf1 Ccna2 Jund Nos3 Sp1 Fosl1 Jun Ccnd1 Bglap Mmp2 Cdkn2a Mmp9 Plau Mmp1 Junb Nfatc3 Nfatc2 Hmox1 Txlng Usf2 Lif Il6 Dcn Thbd Ccl12 Mgp Atf4 Col1a2 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Atm H2ax Blm Kat5 Mdm2 Ywhab Rad17 Bid Chek2 Cdc25c Rbbp8 Trim28 Mre11 Dclre1c Nbn Ctbp1 Xrcc4 Terf2 Abl1 Tp53bp1 Rad50 ABRAXAS1 Fancd2 Ube2n Uimc1 Cdc25a Smc1a Brca1 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Apaf1 Nfkbia Rela Mapk8 Map2k7 Cflar Birc3 Bid Casp8 Casp3 Cd247 Ripk1 Fas Fadd Faslg Chuk Daxx Map3k14 Tnfrsf1a Bag4 Cradd Tnf Traf2 Cycs Casp7 Bcl2 Casp6 Nfkb1 Casp9 Casp2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Bgn Sftpa1 Myd88 Vcan Irak4 Tlr6 Chuk S100a9 Cd14 Tirap Tlr4 Tlr3 S100a8 Tlr2 Ikbkb Ikbkg Hspd1 Rhoa Irak2 Irak1 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Il17a Ifng Stat5a Il6st Gata3 Tbx21 Il1b Stat3 Tgfb1 Stat1 Il12rb2 Ebi3 Il27 Il12a Stat4 Stat2 Il18 Jak1 Il12b Tnf Il6 Jak2 Il2 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Ncstn Apaf1 Aph1b Myd88 Diablo Psenen Ntf4 Psen1 Ntf3 Ywhae Zfp110 Ikbkb Traf6 Rhob Birc2 Lingo1 Ikbkg Omg Ntrk1 Mag Mageh1 Bad Smpd2 Bex3 Bex1 Nsmce3 Rtn4 Mapk9 Ripk2 Arhgdia Ndn Casp3 Prdm4 Sort1 Prkacb Mmp7 Furin Mapk10 Plg Sqstm1 Prkci Maged1 Ngfr Cycs Prkcz Pik3r1 Adam17 Mapk8 Rhoa Birc3 Rac1 Bcl2l11 Chuk App Tp53 Akt1 Casp6 E2f1 Bdnf Casp9 Xiap Ngf Shc1 Irak1 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Nkd2 Cul3 Ranbp3 Ctnnb1 Dvl1 Klhl12 Pip5k1b Dvl3 Pi4k2a Lrp6 Cav1 Wnt3a Apc Axin1 Fzd5 Gsk3b Csnk1g1 Ppp2r5a Gsk3a FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Src Cdh1 Sdc2 Cttn Ptpn11 Stat1 Pik3r1 Gab1 Frs2 Pdpk1 Camk2a Grb2 Mapk1 Sos1 Mapk3 Jun Plcg1 Ctnnd1 Bglap Fgf19 Spp1 Runx2 Fos Cbl Ptk2b Mmp9 Plau Il17rd Ncam1 Ssh1 Fgfr2 Rps6ka1 Cdh2 Stat5b Fgf23 Fgfr3 Fgfr4 Fgfr1 Spry2 Akt1 Shc1 Pak4 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Smad4 Smad5 Fkbp1a Amhr2 Amh Bmp7 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Xrcc5 Nrip1 Ar Ncoa2 Ccnd1 Casp8 Uba3 Kdm1a Pawr Hip1 Lats2 Fhl2 Kdm4c Zfp318 Prdx1 Fkbp4 Rps6ka3 Mak Pa2g4 Ube3a Svil Tmf1 Ctdsp1 Nkx3-1 Zmiz1 Snurf Ncoa4 Ncoa6 Ccnd3 Ctnnb1 Kdm3a Tgfb1i1 Tcf4 Ube2i Srf Pias1 Vav3 Gsn Cdkn2a Ptk2b Carm1 Pelp1 Pias3 Tgif1 Prkdc Pias4 Med1 Akt1 Tmprss2 Xrcc6 Cdk6 Brca1 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Egfr Src Ctnnb1 Casr Cdh1 Jup Fmn1 Ajuba Zyx Fyn Pik3r1 Ctnna1 Plcg1 Rhoa Ctnnd1 Akt1 Akt2 Rac1 Vasp IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Il6st Stat3 Crp Ptpn11 Stat1 Hsp90b1 Pik3r1 Lbp Hck Mcl1 Ptpre Gab1 Il6r Fgg Vav1 Mitf Tnfsf11 Cebpb Timp1 A2m Jak1 Pias1 Grb2 Sos1 Map2k6 Bcl2l1 Jun Prkcd Rac1 Fos Mapk11 Mapk14 Junb Irf1 Socs3 Pias3 Il6 Gab2 Myc Map2k4 Akt1 Jak2 Foxo1 Lmo4 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Efna5 Epha2 Epha3 Epha4 Epha6 Epha7 Epha8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Atr Chek1 Ccna2 Rfc5 Rfc3 Rfc4 Mdm2 Mcm7 Rfc2 Smarcal1 Ywhab Ppp2r2b Hus1 Timeless Rpa2 Cep164 Rad17 Ppp2ca Cdc6 Atrip Tipin Brca2 Mcm2 Plk1 Rad1 Clspn Fbxw11 Ywhaz Ppp2r1a Btrc Cdc25c Cdk2 Nbn Rad51 Fancd2 Cdc25a Topbp1 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Ctnnb1 Dvl1 Dvl3 Btrc Lrp6 Csnk1d Csnk1e Wnt3a Apc Axin1 Axin2 Fzd5 Cul1 Gsk3b Skp1 Csnk1a1 Gsk3a IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Irs1 Pxn Raf1 Irs2 Grb10 Ptpn11 Pik3r1 Ywhae Ptk2 Pdpk1 Igf1 Grb2 Sos1 Crk Bad Hras Igf1r Bcar1 Prkd1 Prkcd Ywhaz Nck2 Crkl Rps6kb1 Ptpn1 Akt1 Prkcz Shc1 Rack1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Vcam1 Il1b Il18 Tnf Map2k2 Mapk1 Map2k7 Map2k1 Map2k6 Pgr Mapk3 Map2k4 Map2k3 Antxr1 Casp1 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Pde6b Guca1a Gnat1 Rgs9 Cnga1 Lrat Rho Gucy2f Sag Gnb1 Rdh12 Rgs9bp Grk1 Gucy2e Rpe65 Gngt1 Slc24a1 Cngb1 Guca1b Pde6a Gnb5 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Ccna2 Aurkb Sp1 Map2k1 Ccnb1 Ccnd1 Brca2 Plk1 Fos Chek2 Mmp2 Esr1 Cdkn2a Skp2 Crebbp Cdk1 Onecut1 Ccnb2 Foxm1 Rb1 Cks1b Tgfa Etv5 Cdk4 Nfatc3 Lama4 Cdk2 Xrcc1 Cenpa Cenpf Cdc25b Ccne1 Myc Gsk3a IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Prkce Plcb3 Lyn Plcb1 Gnai2 Fgr Hck Arrb1 Prkcg Dnm1 Gnb1 Rab5a Pdpk1 Grk2 Prkca Pik3r6 Pik3cg Cbl Cxcr1 Arrb2 Gna15 Gna14 Akt1 Pld1 Plcb2 Prkcb BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Itgb2 Itgal Fgg Ccn1 Jam3 Plat Icam1 C3 Thy1 Cd40lg Plau Vcam1 Spon2 Proc Gp1ba Fgb Fga F10 Fcgr2a Itgad F11r Icam2 Itgax Kng2l1 Itgam INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Stxbp4 Stx4 Slc2a4 Ins2 Ywhah Ywhag Ywhae Insr Prkci Ywhab Ppp1cc Sfn Asip Trip10 Ppp1r3a Vamp2 Gsk3b Gys1 Akt1 Prkcz Akt2 Lnpep Ywhaz Rhoq PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Tagln Myocd Nckap1 Actn4 Raf1 Nherf2 Nherf1 Wasf2 Sipa1 Cttn Pdgfrb Abi1 Rap1b Pdgfb Arhgap35 Map2k2 Map2k7 Map2k1 Pik3cb Brk1 Arhgdia Baiap2 Arpc1b Actr2 Actr3 Mapk10 Arpc3 Arpc2 Eif2ak2 Arpc5 Arpc4 Map2k4 Blk Jak2 Stat5a Lyn Stat3 Stat1 Fgr Pik3r1 Hck Srf Pak1 Mapk8 Mapk1 Ppp2ca Itgav Mapk3 Rhoa Pten Bcar1 Rac1 Ppp2r1a Pin1 Ptpn1 Csk Shc1 Rasa1 Src Braf Grb10 Elk1 Ptpn11 Eps8 Nck1 Ywhah Rap1a Ywhag Gab1 Pla2g4a Ywhae Dok1 Jund Rab5a Lrp1 Ywhab Grb2 Prkca Sfn Sos1 Crk Hras Plcg1 Prkcd Ywhaz Mapk9 Vav2 Rps6ka3 Abl1 Kras Nras Prkce Fyn Yes1 Ppp2r2b Dnm2 Pik3r6 Pik3cg Jun Nck2 Fos Cbl Stat5b Ptpn2 Sphk1 S1pr1 Myc Lck Sla Afdn Arap1 Rab4a Usp6nl ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Fkbp1a Acvrl1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Tln1 Src Ctnnb1 Pip5k1c Nectin2 Vav2 Cdh1 Nectin1 Nectin3 Ptprm Pdgfrb Pik3r1 Cldn1 Rap1a Rap1b Pdgfb Ctnna1 Ptk2 Farp2 F11r Crk Itgav Rac1 Afdn BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Rasa1 Raf1 Elk1 Cd72 Cd22 Malt1 Cd79b Bcl2a1 Pdpk1 Dok1 Bcl10 Ptprc Nfkbib Ikbkb Traf6 Ppp3cc Grb2 Ppp3cb Ikbkg Sos1 Sh3bp5 Map2k1 Hras Map4k1 Btk Vav2 Fcgr2b Nfkb1 Csnk2a1 Dapp1 Nfkbia Rela Plcg2 Blnk Lyn Pik3r1 Ets1 Mapk8 Mapk1 Mapk3 Jun Pten Map3k7 Rac1 Inpp5d Fos Ptpn6 Syk Map3k1 Chuk Mapk14 Camk2g Csk Ppp3ca Akt1 Shc1 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Mcf2l Arhgef1 Arhgef2 Abr Trio Mcf2 Vav1 Arhgap35 Bcr Arhgap9 Ect2 Arhgef25 Srgap1 Arhgef5 Arhgef3 Ophn1 Rhoa Arhgdig Arhgef12 Arhgef18 Farp1 Arhgdia Vav3 Net1 Arhgef15 Arhgap4 Arhgap8 Ngef Vav2 Arhgap5 Arhgdib Cdkn1b Arhgef11 Arhgef28 Arap1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Stxbp1 Unc13b Chrna1 Snap25 Syt1 Rab3gap2 Stx1a Vamp2 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Ncstn Aph1b Gata3 Psenen Dnm1 Ccnd1 Cul1 Skp1 Rab11a Cbl Il4 Maml1 Maml2 Skp2 Itch Furin Adam12 Btrc Ptcra Dll1 Mark2 Dll3 Dll4 Kdm1a Adam10 Rbbp8 Neurl1 Yy1 Cdkn1a Mfap5 Notch1 Jag2 Jag1 Eno1 Mfap2 Dlk1 Mib1 Cntn1 Cntn6 Ctbp1 Notch2 Myc Notch3 Hdac1 Dner Lnx1 Numb Eps15 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Ccnd3 Stat5a Elf1 Ccna2 Ptpn11 Ccnd2 Pik3r1 Jak3 Jak1 Grb2 Sp1 Sos1 Bcl2l1 Il2ra Lta Il2 Prf1 Il4 Faslg Il2rg Stat5b Foxp3 Gab2 Myc Lck Bcl2 Cdk6 Shc1 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Src Raf1 Stat3 Ptpn11 Erbb2 Pik3r1 Nrg2 Grb2 Mapk8 Ppp3cb Map2k2 Mapk1 Sos1 Map2k1 Bad Hras Mapk3 Jun Rac1 Pik3cb Mapk9 Prkaca Fos Mtor Chrna1 Mapk10 Nrg1 Kras Akt1 Erbb3 Nfatc4 Jak2 Nf2 Chrne Usp8 Nras Shc1 Rnf41 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Cxcr2 Rab7a Rac2 Plcb3 Lyn Plcb1 Dock2 Elmo1 Gnai2 Fgr Hck Arrb1 Prkcg Dnm1 Gnb1 Rab5a Pdpk1 Prkca Pik3r6 Pik3cg Ppp2ca Rab11a Vasp Cbl Ppp2r1a Arrb2 Gna15 Gna14 Akt1 Plcb2 Pld2 Prkcb FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc1 Sdc3 Sdc2 Sdc4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Lamb1 L1cam Cd47 Ibsp Pdgfrb Vegfa Pdgfb Fgg Sdc4 Ccn1 Itgav Spp1 Thy1 Col1a1 Col4a3 Plau Col4a1 Lama4 Lamc1 Col4a5 Vtn Fgb Sdc1 Fga F11r Sphk1 Fn1 Tgfbr2 Itga2b Col1a2 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Rasa1 Irs1 Raf1 Irs2 Ptpn11 Grb2 Map2k2 Sos1 Mapkapk2 Map2k1 Hras Mapk9 Mapk11 Cdk2 Socs3 Kras Nras Prkcb Prkce Stat5a Stat3 Fyn Stat1 Socs2 Pik3r1 Stam2 Ikzf3 Stam Jak3 Jak1 Mapk8 Mapk1 Cish Mapk3 Jun Rhoa Il2ra Fos Syk Il2 Ptk2b Ifng Mapk14 Il2rg Stat5b Gab2 Myc Lck Bcl2 Shc1 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc3 Gpc2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Atr Chek1 Csnk1e Npas2 Nr1d1 Nono Cry1 Cry2 Clock Bmal1 Timeless Per2 Per1 Wdr5 Bhlhe40 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Il12rb2 Il12a Map2k6 Ripk2 Cd3g Cd247 Cd3d RT1-Da Tbx21 RT1-Db1 Stat4 Il18 Il12b Eomes Cd4 Cd8b Sphk2 Cd8a Nfkb1 B2m Jak2 Nos2 Rab7a Rela Stat5a Il18r1 Il1b Stat3 Stat1 Stat6 Nfkb2 Ccr5 Gadd45g Gzma Map2k3 Il2ra Gadd45b Hlx Fos Ccl4 Il1r1 Il2 Il4 Mtor Ifng Faslg Mapk14 Il2rg Atf2 Lck BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Sdc1 Plau Itgb8 Vcam1 Itgav Itgb6 Madcam1 Itgb7 Tgfbr1 Fn1 Vtn Ccn1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Irs1 Src Pxn Ptpn11 Vegfa Ptk2 Rock1 Igf1 Col11a1 Igf1r Col11a2 Casp8 Col2a1 Col3a1 Col1a1 Col4a3 Col5a2 Col6a2 Col4a1 Col5a1 Fgf2 Col4a5 Sdc1 Cdkn1b Pik3r1 Mapk1 Ilk Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Vav3 Angptl3 Cbl Mfge8 Tln1 Pi4kb Ptk2b Pik3c2a Rps6kb1 Vcl Csf1 Vtn Csf1r Hsp90aa1 F11r Akt1 Fn1 Tgfbr2 Col1a2 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Crebbp Tubb2a Mef2d Acss1 Myod1 Cdkn1a Hdac4 Fhl2 Tp53 Sirt3 Sirt2 Sirt1 Bax Ppargc1a Foxo4 Foxo3 Foxo1 Xrcc6 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Rara Nrip1 Prkcg Ncoa2 Ncoa1 Mapk8 Prkca Mapk1 Mapk3 Prkaca Vdr Crebbp Cdk1 Mnat1 Ccnh Mapk14 Cdk7 Rbp1 Hdac3 Rxrb Rxra Hdac1 Rarg Akt1 Rxrg HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Cdkn2a Vhl Eloc Rbx1 Hif3a Os9 Cops5 Naa10 Cul2 Hsp90aa1 Tp53 Arnt Hif1an Egln2 Egln3 Hif1a Rack1 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Sftpa1 Foxa1 Foxa2 Foxa3 Col18a1 Nrip1 Cebpb Ap1b1 Ar Shh Sp1 Dscam Jun Tff1 Apob Atp5pf Fos Xbp1 Esr1 Sod1 Pou2f1 Crebbp Ndufv3 Prdm15 Ins2 Vtn Pisd Sftpd Nfib Cdkn1b Nfia Nfic Scgb1a1 Nr2f2 Gcg C4bpb Serpina1 Nkx3-1 Brca1 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Tab2 Ror2 Yes1 Rock1 Camk2a Mapk8 Rhoa Csnk1a1 Map3k7 Rac1 Mapk9 Dvl1 Dvl3 Mapk10 Nfatc2 Arrb2 Wnt5a Nlk Pparg Cthrc1 Fzd2 Fzd5 Prkcz Daam1 Flna Fzd6 Chd7 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Src Gnai1 Plcb3 Gnai3 Plcb1 Gnaz Gnao1 Gnai2 Pik3r1 Gnb1 Hbegf Nos3 Igf1 Gna13 Grb2 Sos1 Hras Msn Igf1r Rhoa Bcar1 Mmp2 Esr1 Esr2 Mmp9 Rock2 Mapk11 Gna11 Gna15 Pelp1 Gna14 Gnaq Kras Akt1 Gnal Plcb2 Strn Nras Shc1 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Myog Mdfic Igf2bp1 Cby1 Vcan Id2 Fgf4 Zcchc12 Tbl1xr1 Kcnip4 Tnik Adcy7 Ccnd2 Mt-co2 Camk4 Ywhah Tle4 Ywhag Med12 Ywhae Tle2 Mitf Krt1 Ruvbl2 Tle5 Dkk4 Ar Ywhab Chd8 Ncoa2 Smarca4 Tcf7 Tbl1x Sfn Sp5 Cdx4 Axin2 Cdx1 Ccnd1 Ctnnbip1 Klf4 Hbp1 Pitx2 Ywhaz Myf5 Dvl3 Tle1 Dkk1 Ctnnb1 Tcf4 Cdh1 Incenp Xpo1 Tcf7l2 Ccn1 Apc Jun Cul1 Skp1 Mmp2 Cdkn2a Mmp9 Tcf7l1 Btrc Tbxt Lef1 Hdac2 Ctbp1 Myc Tert Hdac1 Neurog1 Cacna1g EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Irs2 Plcg2 Stat5a Lyn Ptpn11 Stat1 Pik3r1 Rap1a Gab1 Grb2 Mapk8 Sos1 Bcl2l1 Hras Epor Epo Plcg1 Inpp5d Ptpn6 Tec Cbl Crkl Btk Vav2 Mapk14 Stat5b Socs3 Bcl2 Nfkb1 Jak2 Shc1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Map3k10 Tab2 Atm Map3k1 Mapk11 Mapk14 Txn Gadd45a Traf6 Map3k3 Camk2b Traf2 Map2k6 Gadd45g Map2k3 Gadd45b Map3k7 Rac1 Taok1 Taok3 Map3k6 Map3k4 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Cdkn2a Skp2 Pin1 Supt7l Pak2 Zbtb17 Kat5 Max Ruvbl2 Ppp2ca Ruvbl1 Myc Axin1 Gsk3b Hbp1 Actl6a Kat2a Ppp2r5a Taf9 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Gnai1 Gnai3 Gnaz Gnao1 Gnai2 Pdgfrb Vegfa Ptgs2 Pdgfb Abcc1 Sphk1 Mapk1 S1pr1 Mapk3 Plcg1 Rhoa Rac1 Plcb2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Prnp Lama1 Pla2g2a Src Slit2 Smad2 Serpinc1 Lyn Cripto Tgfb1 Fyn Yes1 Fgr Tgfb3 Nrg1 Hck Fgf2 Vegfa App Fgfr1 Lck Blk Tgfbr1 Tgfbr2 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Gnai1 Src Raf1 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Adcy7 Pla2g4a Prkca Map2k2 Crk Map2k1 Hras Prkcd Col3a1 Ednrb Ednra Mmp1 Adcy3 Adcy4 Adcy2 Adcy8 Adcy5 Adcy6 Edn2 Edn3 Prkch Cysltr2 Cysltr1 Prkcq Jak2 Plcb2 Prkcb Prkce Plcb3 Edn1 Plcb1 Trpc6 Prkcg Slc9a1 Mapk8 Slc9a3 Mapk1 Mapk3 Jun Rhoa Bcar1 Rac1 Fos Ptk2b Mapk14 Gna11 Gna15 Gna14 Gnaq Akt1 Gnal Col1a2 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Nrp1 Nrp2 Flt4 Pgf Vegfa Vegfd Vegfc NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Trpc6 Fyn Tjp1 Pik3r1 Nck1 Grb2 Mapk8 Bad Jun Plcg1 Rac1 Pik3cb Mapk9 Nck2 F2rl2 Mapk10 Arrb2 Prkci Nphs2 Map2k4 Nphs1 Akt1 Prkcz Cd2ap Kirrel1 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Tiam1 Egfr Gnai1 Src Pxn Nherf2 Gnai3 Gna12 Gnaz Gnao1 Gnai2 Adcy7 Gab1 Ptk2 Crk Hras Plcg1 Gsk3b Prkcd Pik3cb Casp3 Adcy3 Adcy4 Adcy2 Adcy8 Adcy5 Adcy6 Nfkb1 Lpar4 Lpar3 Lpar2 Lpar1 Adra1b Pld2 Prkce Nfkbia Plcb3 Rela Arhgef1 Lyn Pik3r1 Gnb1 Hbegf Gna13 Jun Rhoa Bcar1 Prkd1 Rac1 Fos Mmp2 Ptk2b Mmp9 Gna11 Gna15 Gna14 Gnaq Akt1 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Lama1 Lama3 Col18a1 Vegfa Col11a1 Col11a2 Mdk Jam2 Col2a1 Cd81 Col3a1 Col1a1 Col4a3 Col5a2 Vcam1 F13a1 Col6a2 Igsf8 Cd14 Thbs2 Col4a1 Col5a1 Lamc1 Col4a5 Tgm2 Lama5 Itga10 Itga7 Itga8 Itga3 Itga5 Itga6 Itga9 Itgb1 Nid1 Lamb2 Itga1 Cspg4 Lamb3 Itga2 Lamb1 Fgg Itgav Spp1 Plau Lama4 Vtn Fgb Fga Fn1 Col1a2 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Egfr Src Ctsg Itgb2 Fpr1 Klk4 Fpr3 Fpr2 Dock1 Serpine1 Gpld1 Mmp12 Pdgfrb Mmp13 Ctrc Vldlr Fgg Lrp1 Crk Itgav Bcar1 Rac1 Mmp9 Plau Tgfb1 Hgf Plg Vtn Elane Fgb Fga Itga3 Itga5 Fn1 Itgb1 Itgam VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Rbl1 Id2 Pdgfrb Max Gadd45a Sp1 Ccnd1 Cflar Ccl5 Smad2 Smad3 Smad4 Zbtb17 Hdac3 Cdkn1a Wnt5a Dntt Cdkn1b Lgals1 Itga6 Itgb1 Dkk1 Itgb4 Erbb2 Spi1 Tmeff2 Gfi1 Aldh9a1 Clu Fth1 Tmem126a Sfrp1 Tbp Csde1 Tsc2 Hmgcs2 Nfyb Irf8 Nfya Ptpa Nfyc Zfp36l1 Dnmt3a Gtf2h2 Slc11a1 Sfxn3 Ndrg1 Ndrg2 Tjp2 Cebpa Myc Hdac1 Bcl2 Cdkn2b Foxo3 Creb1 Col1a2 Brca1 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Egfr Areg Tgfa Erbb2 Erbb4 Nrg1 Ereg Hbegf Egf Nrg2 Btc Hsp90aa1 Nrg4 Nrg3 Erbb3 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Camk4 Nr3c1 Ranbp2 Xpo1 Ywhae Hdac4 Gnb1 Srf Ube2i Ran Ywhab Grk2 Esr1 Ankra2 Tubb2a Rfxank Mef2c Hdac3 Hdac11 Bcl6 Hdac10 Hdac7 Gata1 Hsp90aa1 Gata2 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Tab2 Ctnnb1 Ywhae Pdpk1 Camk2a Ccn2 Grb2 Sos1 Ppp2ca Fkbp1a Map3k7 Itch Smad2 Rps6kb1 Smad3 Strap Dynlrb1 Smad4 Daxx Dab2 Dact2 Tgfb1 Wwp1 Tgfbrap1 Tgfb3 Zfyve16 Ppp2cb Arrb2 Tgfbr3 Ppp1ca Sptbn1 Ppp2r2a Smad7 Cav1 Rnf111 Ppp1r15a Zfyve9 Bambi Axin1 Nedd4l Smurf1 Tgfbr1 Tgfbr2 Xiap Shc1 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Cdh1 Itgb7 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Map3k1 Lcp2 Map3k8 Mapk8 Dbnl Crk Jun Map2k4 Grap2 Lat Map3k7 Map4k1 Crkl Prkcb ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Prkce Nr4a1 Map3k8 Camk4 Ywhah Ywhag Xpo1 Prkcg Ywhae Ran Ywhab Mapk8 Prkca Sfn Bad Bcl2l1 Mapk3 Chp1 Rcan2 Gsk3b Fkbp1a Prkcd Csnk1a1 Ywhaz Mapk9 Prkaca Casp3 Pim1 Cabin1 Crebbp Map3k1 Mef2d Akap5 Mapk14 Nfatc3 Nfatc2 Prkch Fkbp8 Prkcq Kpna2 Bcl2 Kpnb1 Prkcz Bax Csnk2a1 Prkcb TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Map3k8 Ptpn11 Nck1 Rap1a Malt1 Vav1 Pdpk1 Bcl10 Ptprc Ikbkb Traf6 Grb2 Prkca Ikbkg Sos1 Hras Plcg1 Grap2 Itk Map4k1 Cd3g Cd247 Cd3d Cd28 RT1-Da Cd86 Lcp2 Cd80 RT1-Db1 Prkcq Cd4 Kras Zap70 Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Pten Inpp5d Ptpn6 Cbl Chuk Map3k14 Trpv6 Csk Dbnl Gab2 Sla2 Orai1 Lck Stim1 Akt1 Stk39 Lat Flna Rassf5 Fyb1 Sh3bp2 Shc1 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Rasa1 Ptpn11 Pik3r1 Nck1 Vegfa Nos3 Cav1 Pdpk1 Hsp90aa1 Nrp1 Shc2 Prkca Nrp2 Mapk1 Pgf Mapk3 Plcg1 Akt1 Cd2ap Prkaca Hif1a Cbl Prkcb EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Egf Mtor Egfr Grb2 Edn1 Sos1 Hras Ednra Shc1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Ift88 Kif3a Stk36 Gnai1 Sufu Foxa2 Spop Gnai3 Gnaz Gnao1 Gnai2 Xpo1 Gnb1 Gli2 Shh Pias1 Smo Ptch1 Map2k1 Sap18 Gsk3b Prkcd Csnk1a1 Fbxw11 Csnk1g3 Prkaca Csnk1g1 Csnk1g2 Rbbp7 Crebbp Btrc Csnk1d Arrb2 Csnk1e Hdac2 Hdac1 Akt1 Lgals3 Rab23 Gli1 Mtss1 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Rasa1 Irs1 Grb10 Ptpn11 Pik3r1 Nck1 Exoc3 Eif4ebp1 Exoc5 Pdpk1 Exoc6 Dok1 Exoc2 Grb2 Sos1 Crk Exoc7 Hras Sh2b2 Inpp5d Nck2 Cbl Ptpra Rps6kb1 F2rl2 Ins2 Grb14 Sgk1 Insr Prkci Cav1 Ptpn1 Trip10 Akt1 Prkcz Akt2 Rhoq Foxo3 Shc1 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfa Pdgfc Pdgfra Pdgfrb Pdgfb EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Tiam1 Src Epha2 Inppl1 Vav2 Acp1 Pik3r1 Arhgap35 Ptk2 Pak1 Grb2 Rhoa Bcar1 Efna1 Rac1 Vav3 Shc1 Cbl ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Egfr Src Nckap1 Raf1 Braf Wasf2 Elk1 Arf4 Ppp5c Eps8 Diaph3 Atf1 Zfp36 Abi1 Ywhah Map3k2 Ywhag Gab1 Myl11 Ywhae Map2k5 Dusp6 Pdpk1 Rab5a Ralgds Egf Ywhab Grb2 Prkca Map2k2 Sos1 Sfn Dusp1 Egr1 Map2k1 Bad Hras Rps6ka5 Prkcd Ywhaz Pik3cb Mapk9 Brk1 Baiap2 Arpc1b Actr2 Vav2 Actr3 Mef2c Arpc3 Arpc2 Arpc5 Arpc4 Rps6ka3 Map2k4 Kras Prkcz Pld1 Nras Pld2 Capn2 Pebp1 Rin1 Stat3 Stat1 Rala Pik3r1 Srf Slc9a1 Mapk8 Mapk1 Ppp2ca Bcl2l1 Mapk3 Jun Rac1 Fos Mtor Ppp2r1a Map3k1 F2rl2 Sh2d2a Atf2 Ppp2r2a Smad1 Rps6 Rictor Akt1 Mapkap1 Creb1 Mlst8 Usp6nl LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Nudc Cdk5 Vldlr Map1b Ywhae Ppp2r5d Katna1 Pafah1b3 Pafah1b2 Lrp8 Lrpap1 Pafah1b1 Dab1 Dync1h1 Dynlt1 Cdk5r1 Rhoa Ndel1 Abl1 Reln Dcx Csnk2a1 Rac1 Pla2g7 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Atf5 Itga1 Src Ccna2 Cdk2 Cdkn1a Ccne1 Rock1 Agt Mapk1 Egr1 Mapk3 Rhoa Bcar1 Rac1 Ptp4a3 Ptp4a1 Itgb1 Rabggta Rabggtb EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Tiam1 Rgs3 Src Ephb1 Lyn Ephb2 Ptpn13 Efnb1 Fyn Efnb2 Yes1 Fgr Pik3r1 Hck Dnm1 Mapk8 Map2k4 Lck Blk Map3k7 Rac1 Nck2 Itga2b VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Itga1 Col1a1 Itga2 Mapk11 Mapk14 Pik3r1 Rps6ka1 Vegfd Vegfc Grb2 Mapk1 Sos1 Flt4 Crk Mapk3 Map2k4 Itga5 Akt1 Fn1 Itgb1 Creb1 Col1a2 Shc1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Egfr Src Pxn Tshr Adap1 Adrb2 Git1 Nck1 Acap1 Arrb1 Agtr1 Egf Arf6 Efna1 Gulp1 Epha2 Fbxo8 Acap2 Lhcgr Arap2 Hgf Arrb2 Gna11 Gna15 Gna14 Met Gnaq Cyth2 Itga2b Cyth3 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Ada Tp63 Serpine1 Ccna2 Kat5 Sp1 Sfn Ntrk1 Plk3 Plpp1 Hey2 Fas Prkacb Mapk11 Rb1 Pfdn5 Tuba1a Ccne2 Cdk2 Pea15 Il1rap Ndufs2 Cdkn1a Hagh Gramd4 Jag2 Aen Dcp1b Gata1 Rnf43 Dedd Flot2 Afp Hsf1 Wt1 Nedd4l Bak1 Sirt1 Abl1 Ube4b Tp73 Bax Nsg1 Gdf15 Rela Chek1 Wwox Mdm2 Jak1 Bub1 Ccnb1 Bin1 Brca2 Plk1 Bcl2l11 Itch Pin1 Cdk1 Mapk14 Il4r Myc Serpina1 Rad51 Foxo3 Rchy1 Casp2 Cdk6 Rack1 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Cxcl13 Src Gnai1 Raf1 Gnai3 Gnaz Gnao1 Gnai2 Pik3r1 Arrb1 Dnm1 Gnb1 Pdpk1 Map2k2 Mapk1 Map2k1 Map2k6 Hras Mapk3 Map2k3 Pik3cb Mtor Ccl11 Mapk11 Mapk14 Cxcl9 Rictor Kras Akt1 Cxcl11 Cxcl10 Mapkap1 Cxcr3 Nras Pf4 Mlst8 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Cnksr1 Il3ra Prkacb Srp9 Stat5a Ptpn11 Pik3r1 Stat5b Id1 Ywhag Cebpb Csf2rb Grb2 Cish Gab2 Bcl2l1 Osm Hdac1 Jak2 Ywhaz Inpp5d Prkaca Shc1 Pim1 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Egfr Src Nherf1 Gna12 Gnai2 Dnm1 Nos3 Rock1 Egf Sele Grk2 Prkca Icam1 Prkcd Rab11a Vcam1 Mapk11 Tgm2 Prkch Prkcq Arr3 Prkcz Blk Plcb2 Prkcb Gnb5 Prkce Ptgdr Ptgir Arhgef1 Lyn Tbxa2r Grk3 Fyn Fgr Yes1 Hck Prkcg Gnb1 Gna13 Pik3r6 Pik3cg Rhoa Rac1 Prkaca Syk Mapk14 Arrb2 Gna11 Gna15 Gna14 Gnaq Lck Akt1 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Itgb4 Lamb2 Egfr Lama1 Lamb3 Lama3 Lamb1 Cdh1 Col17a1 Pmp22 Erbb2 Pik3r1 Ywhah Ywhag Ywhae Egf Ywhab Grb2 Prkca Sfn Hras Mst1r Rac1 Ywhaz Rps6kb1 Mst1 Lama4 Lamc1 Il1a Lama5 Met Rxrb Rxra Casp7 Akt1 Erbb3 Rxrg Itga6 Itgb1 Shc1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Irs1 Raf1 Srebf1 Braf Ywhah Ywhag Eif4ebp1 Ywhae Eif4a1 Pdpk1 Ywhab Ikbkb Prkca Map2k2 Sfn Map2k1 Eif4e Hras Ppargc1a Ywhaz Cdk2 Rps6ka1 Yy1 Cycs Rptor Kras Pld1 Nras Pld2 Akt1s1 Prr5 Rraga Ddit4 Rragb Rragc Rragd Tsc1 Eif4b Ulk1 Ulk2 Rb1cc1 Mapk1 Rrn3 Tsc2 Poldip3 Pdcd4 Mapk3 Bnip3 Atg13 Eef2 Eef2k Fbxw11 Mtor Rps6kb1 Btrc Sgk1 Ccne1 Rictor Akt1 Mapkap1 Mlst8 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Btrc Chuk Nfkb2 Map3k14 Nfkb1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Egfr Tp63 Col18a1 Serpine1 Atf3 Bcl2a1 Pou4f1 E2f3 Pou4f2 Cd82 Sp1 Plk3 Bid Kat2a Vdr Fas Crebbp Rb1 Ctsd Cdkn1a Afp Bak1 Tp73 Bax Gdf15 Foxa1 Ddit4 Mdm2 Cse1l Apc Ccnb1 Pten Drosha Spp1 Ccnk Pcbp4 Tap1 Bdkrb2 Ccng1 Hic1 Ppp1r13b Igfbp3 Msh2 Mmp2 Tnfrsf10b Sh2d1a Sesn1 Steap3 Tada2b Fdxr Ddx5 Btg2 Rrm2b Tp53bp2 Prmt1 Bcl2l14 Carm1 Gpx1 Bcl2l2 Perp Cav1 Bnip3l Rnf144b Triap1 Irf5 Lif Aifm2 Dgcr8 Tp53 Htt Scn3b Pidd1 Zfp385a Pms2 Cx3cl1 Pycard Pcna Mlh1 Tp53inp1 Tigar Rchy1 Nlrc4 Casp1 Prdm1 Prkab1 Apaf1 Ppm1j Vcan Serpinb5 Gadd45a Smarca4 Dusp5 Sfn Dusp1 Epha2 Hgf Edn2 Met Dkk1 Mcl1 Tsc2 Bcl2l1 Jun Nfyb Nfya Nfyc Ndrg1 Tgfa Bcl6 Hdac2 Bcl2 Casp6 E2f1 Taf9 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Prkce Adcy3 Adcy4 Adcy7 Adcy2 Adcy8 Adcy5 Adcy6 Rps6ka5 Lpar4 Prkaca Gnal Creb1 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Tiam1 Rab7a Egfr Src Slit1 Ctnnb1 Cbll1 Dsp Gna12 Cdh1 Cables1 Jup Igf2 Gdnf Robo1 Fyn Zbtb33 Gfra1 Snx1 Ctnna1 Rab5a Egf Nme1 Gna13 Ntrk2 Dnm2 Hras Igf1r Ctnnd1 Arf6 Rac1 Ptpn6 Casp3 Crebbp Mmp7 Cdh2 Adam10 Hgs Ptpn1 Met Abl1 Bdnf Ret Rin2 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Rasa1 Nfkbia Arhgef7 Ajuba Aurkaip1 Aurkb Oaz1 Git1 Cpeb1 Dlgap5 Fzr1 Tdrd7 Pak1 Mdm2 Ran Gadd45a Ndel1 Gsk3b Prkaca Tpx2 Tacc3 Ckap5 Aurka Cenpa Cdc25b Ppp2r5d Tp53 Akt1 Tacc1 Brca1 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Nfkbia Rela Stat5a Pik3r1 Fcamr Traf3 Jak3 Cd40 C4bpa Traf6 Tdp2 Mapk8 Birc2 Pik3r6 Pik3cg Bcl2l1 Jun Birc3 Pik3cb Mapk9 Il4 Cblb Map3k1 Cd40lg Mapk10 Mapk11 Map3k14 Mapk14 Traf2 Myc Map2k4 Akt1 Nfkb1 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network Ncoa2 Esr2 Ncoa1 Smarca4 Nr0b2 Nr0b1 Smarcb1 Zfp709 Uba3 Smarce1 Nedd8 C3 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurkc Aurkb Aurka LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Akt1s1 Ywhah Ywhag Ywhae Tsc1 Ywhab Sfn Stk11ip Tsc2 Stk26 Mark4 Crtc2 Map2 Gsk3b Stradb Smarcd3 Ywhaz Cab39 Prkaca Strada Etv4 Stk11 Esr1 Psen2 Mtor Sik1 Brsk2 Ezr Brsk1 Smad4 Mark2 Cdc37 Ctsd Hsp90aa1 Tp53 Myc Rptor Creb1 Mlst8 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb1 Ephb2 Ephb3 Efnb1 Efnb2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Raf1 Braf Elk1 Ntf3 Rap1a Rap1b Map3k2 Map2k5 Srf Trpv1 Mapk1 Mapkapk2 Egr1 Map2k1 Map2k6 Hras Mapk3 Cdk5r1 Rps6ka5 Map2k3 Prkcd Fos Mef2c Mapk14 Cdk5 Rps6ka1 Kras Rit1 Rit2 Ehd4 Creb1 Nras TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Tab2 Rela Tnik Stat1 Adam17 Ikbkb Birc2 Ikbkg Map3k3 Map2k7 Smpd2 Birc3 Map2k3 Map3k7 Casp8 Ripk1 Fadd Map3k1 Nrk Map4k5 Map4k3 Chuk Tnfrsf1b Cyld Map4k2 Rffl Sqstm1 Nsmaf Madd Prkci Cav1 Smpd1 Txn Tnfrsf1a Bag4 Tnf Traf2 Prkcz Nfkb1 Rack1 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Hadh Foxa1 Foxa2 Foxa3 Tfrc Nr3c1 Cebpb Sp1 Ins2 G6pc1 Pklr Tat Aldob Hnf4a Nkx2-1 F2 Cebpa Acadvl Hmgcs1 Ttr Dlk1 Igfbp1 Slc2a2 Afp Ucp2 Nf1 Pck1 Acadm Gck Cpt1a Akt1 Bdh1 Abcc8 Kcnj11 Alb Hnf1a Creb1 Cpt1b Cpt1c CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Tiam1 Enah Src Raf1 Braf Eps8 Diaph3 Dlg1 Map2k7 Map2k6 Hras Gsk3b Mapk9 Arhgdia Baiap2 Iqgap3 Arpc1b Actr2 Vav2 Actr3 Pak2 Arpc3 Arpc2 Arpc5 Arpc4 Map3k11 Map2k4 Prkcz Pld1 Pak4 Cdc42bpa Prkce Ctnnb1 Septin2 Pax6 Arhgef7 Hes5 Cdh1 Tnk2 Arhgef6 Pik3r1 Yes1 Ctnna1 Pak1 Mapk8 Mapk1 Apc Cfl1 Exoc7 Mapk3 Jun Bcar1 Map2k3 Rac1 Myl2 Limk1 Limk2 Cbl Mtor Map3k1 Rps6kb1 F2rl2 Mapk14 Atf2 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Gnai1 Src Pxn Gnai3 Gnaz Gnao1 Gnai2 Ptpn11 Rap1b Dnm1 Vav1 Ptk2 Pdpk1 Ptprc Stat2 Rhob Grk2 Crk Bad Pik3cb Cd3g Cd247 Cd3d RT1-Da RT1-Db1 Ssh1 Cxcr4 Cd4 Arr3 Prkcz Blk Jak2 Plcb2 Plcb3 Stat5a Lyn Plcb1 Rgs1 Ubqln1 Stat3 Vps4a Fyn Stat1 Fgr Vps4b Pik3r1 Yes1 Hck Grk6 Gnb1 Cxcl12 Pak1 Gna13 Pik3r6 Pik3cg Cfl1 Rhoa Bcar1 Rac1 Inpp5d Limk1 Ptpn6 Mtor Ptk2b Mmp9 Itch Ralb Stat5b Hgs Arrb2 Csk Lck Rictor Akt1 Foxo1 Mapkap1 Rack1 Mlst8 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Th Raf1 Mapk11 Mapk14 Etv1 Ywhah Tcf3 Cdc25b Lsp1 Ywhag Ywhae Srf Ywhab Hspb1 Mapkapk3 Mapkapk2 Sfn Tsc2 Ywhaz Creb1 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Ncstn Dkk1 Aph1b Ctnnb1 Psenen Psen1 Nedd4 Dkk2 Tle5 Mapk1 Apc Mapk3 Jun Ccnd1 Gsk3b Csnk1a1 Map3k7 Fbxw11 Fos Dvl1 Crebbp Btrc Dll1 Tle1 Lrp6 Adam10 Notch1 Nlk Wif1 Ppp2r5d Wnt1 Fzd1 Ctbp1 Myc Axin1 Hdac1 Kremen2 Csnk2a1 Hnf1a Ppard VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Itgb4 Ada Cables1 Tp63 Serpinb5 Dhrs3 Traf4 Mdm2 Ogg1 Spata18 Gadd45a Shh Ikbkb Tfap2c Nqo1 Sp1 Noc2l Ssrp1 Dicer1 Plk1 Hbp1 Prkcd Smarcd3 Vdr Igfbp3 Mfge8 Cdkn2a Fas Itch Btrc Egr2 Fdxr Chuk Wwp1 Cdkn1a Jag1 Aen Perp Flot2 Itga3 Abl1 Bax Gdf15 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Il1b Stat3 Ptpn11 Stat1 Pik3r1 Ifngr1 Rap1a Rap1b Dapk1 Cebpb Camk2a Jak1 Pias1 Mapk1 Map2k1 Mapk3 Irf9 Prkcd Camk2d Cbl Crkl Mtor Crebbp Ifng Map3k1 Irf1 Ptpn2 Camk2g Smad7 Map3k11 Pias4 Camk2b Akt1 Jak2 Casp1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Cltb Arfgap1 Cd4 Ap2m1 Arf1 Gbf1 Uso1 Gga3 Rac1 Kdelr1 Asap1 Cyth2 Ap2a1 Clta Arfip2 Pld2 Gosr2 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Tab2 Myd88 Rela Irak4 Il1b Pik3r1 Ikbkb Traf6 Mapk8 Ikbkg Map3k3 Map2k6 Jun Map3k7 Il1r1 Ube2v1 Ticam2 Irak3 Erc1 Tollip Chuk Il1r2 Il1rn Il1rap Sqstm1 Il1a Prkci Prkcz Nfkb1 Ube2n Irak1 Casp1 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Nr4a1 Gata3 Pomc Ppp5c Ywhah Nr3c1 Ncoa2 Smarca4 Sele Ncoa1 Il5 Sfn Egr1 Icam1 Cdk5r1 Gsk3b Bglap Mapk9 Il13 Prkacb Crebbp Mapk10 Mapk11 Tbx21 Mmp1 Cdk5 Irf1 Cdkn1a Fkbp4 Afp Il6 Bax Nfkb1 Rela Stat5a Stat1 Spi1 Fgg Mdm2 Mapk8 Tbp Mapk1 Mapk3 Jun Prkaca Fos Il2 Il4 Pou2f1 Ifng Csf2 Krt14 Prl Mapk14 Nr1i3 Tsg101 Kmt5b Sgk1 Stat5b Fkbp5 Csn2 Sumo2 Pou1f1 Cga Pck2 Krt17 Hsp90aa1 Hdac2 Pbx1 Smarcc2 Tp53 Hdac1 Akt1 Smarcc1 Creb1 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Ube2d3 Egfr Src Raf1 Arhgef7 Pik3r1 Lrig1 Synj1 Dnm1 Ptk2 Itsn1 Rab5a Egf Grb2 Sos1 Hras Pik3cb Ube2d1 Cbl Sh3gl2 Cblb Tsg101 Hgs Stambp Amph Spry2 Chmp3 Epn1 Kras Ube2d2 Zfyve28 Sh3kbp1 Eps15 Usp8 Nras Shc1 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Tfe3 Sult2a1 Ranbp1 Apaf1 Rbl1 Ces2h Atm Mcm3 Ces4a Dhfr Serpine1 Orc1 Ces5a Ccna2 Rrm2 E2f6 E2f7 E2f3 Sp1 Hbp1 Kat2a Crebbp Rb1 Wasf1 Ccne2 Cdk2 Rbbp8 Yy1 Cdkn1a E2f5 Cdkn1b Cbx5 Sirt1 Tp73 Ccnd3 Mcl1 Cdc6 Hic1 Cdkn2a Plau Cdk1 Rbl2 Smarca2 Xrcc1 Ccne1 Trim28 Cebpa Myc Hdac1 Casp7 E2f1 Uxt Tfdp2 Ces1d Cdc25a Cdkn2c Topbp1 Tyms Mybl2 Brca1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Ube2d3 Nfkbia Atm Rela Erc1 Btrc Chuk Cyld Xpo1 Malt1 Bcl10 Tnfrsf1a Ran Ikbkb Traf6 Birc2 Tnf Prkca Ikbkg Nfkb1 Ripk2 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Efna5 Fyn TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Map3k8 Rap1a Malt1 Vav1 Pdpk1 Bcl10 Ptprc Ikbkb Traf6 Grb2 Prkca Ikbkg Sos1 Hras Plcg1 Grap2 Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Lcp2 Cd80 Prkcq Cd8b Kras Cd8a B2m Zap70 Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Ptpn6 Cbl Chuk Map3k14 Trpv6 Csk Orai1 Lck Stim1 Akt1 Lat Rassf5 Shc1 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Egfr Xrcc5 Atm Terf1 Smg6 Ywhae Tinf2 Max Parp2 Pot1 Acd Egf Znfx1 Terf2ip Hnrnpc Sp1 Pinx1 Sap18 Ccnd1 Sp3 Rbbp7 Esr1 Smad3 Irf1 Cdkn1b Wt1 Ube3a Abl1 Nfkb1 Mxd1 Blm Hus1 Mapk1 Mapk3 Jun Rad1 Fos Il2 Mtor Ifng Rps6kb1 Tgfb1 Mre11 Hsp90aa1 Hdac2 Nbn Nr2f2 Myc Tert Hdac1 Terf2 Akt1 Rad50 E2f1 Xrcc6 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Raf1 Ccna2 Ccnd2 Myod1 Mitf Cebpb Ubtf E2f3 Smarca4 Smarcb1 Tgfb2 Suv39h1 Gsc Brd2 Pax3 Ccnd1 Aatf Rbp2 Bglap Atf7 Runx2 Ckm Mapk9 Taf1 Crebbp Mef2c Mapk11 Rb1 Cdk4 Cdk2 Hdac3 Cdkn1a Met Cdkn1b Pparg Sirt1 Abl1 Ccnd3 Elf1 Spi1 Mdm2 Tbp Ppp2ca Jun Cdkn2a Skp2 Csf2 Mapk14 Atf2 Ccne1 Cebpa Sftpd Ctbp1 Hdac1 Cbx4 E2f1 Cdk6 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Smad2 Map3k1 Smad3 Smad4 Tgfbrap1 Ube2i Pias4 Mapk1 Kpna2 Mapk3 Kpnb1 Ctdsp1 Ppm1a Nup153 Ctdspl HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Id2 Serpine1 Tf Tfrc Vegfa Ncoa2 Ncoa1 Sp1 Arnt Hif1a Plin2 Adm Cp Crebbp Pfkfb3 Furin Nt5e Smad3 Pgm1 Fech Smad4 Pkm Aldoa Cxcr4 Abcb1a Pfkl Rora Hk2 Bhlhe41 Hdac7 Igfbp1 Npm1 Gck Nos2 Gata2 Itgb2 Edn1 Mcl1 Cops5 Ets1 Cxcl12 Bnip3 Jun Epo Bhlhe40 Tff3 Egln3 Fos Cited2 Ndrg1 Pgk1 Slc2a1 Abcg2 Hnf4a Hmox1 Eno1 Tert Lep Akt1 Creb1 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Arhgef2 Fyn Pik3r1 Rap1a Vldlr Map1b Mapk8 Lrp8 Lrpap1 Pafah1b1 Dab1 Map2k7 Grin2b Cdk5r1 Gsk3b Reln Nck2 Cbl Crkl Cdk5 Grin2a Mapk8ip1 Map3k11 Itga3 Akt1 Itgb1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Tnfrsf10b Fadd Map3k1 Chuk Pik3r1 Dap3 Smpd1 Ikbkb Mapk8 Mapk1 Ikbkg Traf2 Mapk3 Map2k4 Cflar Pik3cb Casp8 Ripk1 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Crh Mapk8 Mapk11 Mapk14 Mapk9 Gnal Gnb1 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Itga1 Egfr Src Atr Stat5a Stat3 Stat1 Pdgfrb Pik3r1 Stat6 Vegfa Pdgfb Gab1 Jak3 Egf Jak1 Pias1 Grb2 Sos1 Pik3cb Crebbp Ins2 Hgf Eif2ak2 Stat5b Ptpn2 Csf1 Insr Ptpn1 Csf1r Met Lman1 Kpna2 Kpnb1 Itgb1 Rab4a Shc1 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Tab2 Mapk1 Gsk3b Map3k7 Ppm1a Ctdspl Bmp4 Smad4 Zfyve16 Ppp1ca Bmp7 Smad7 Ppp1r15a Bmpr2 Smad1 Bambi Grem1 Ahsg Sostdc1 Smad9 Rgma Hjv Chrd Fst Smurf1 Smad5 Nog Ctdsp1 Bmpr1a Xiap Bmp6 Bmp2 Smad6 Chrdl1 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events F2rl2 Rock2 Gna11 Gnb1 F2 Gna15 Rock1 Gna14 Gna13 Gnaq Rhoa Myl2 Plcb2 FSH%NETPATH%FSH FSH Map2k2 Grk4 Fshb Fshr Akt2 Grk6 Cga HEDGEHOG%NETPATH%HEDGEHOG Hedgehog Prkaca Ctnnb1 Gli1 Kif7 Med6 Gli2 Grk2 Ywhae Ptch1 Sap18 Dyrk1a Sufu Boc Arrb2 Kif27 Med23 Med12 Med1 Ccnb1 Dhh Hhip Ihh Stk36 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor Ar Hdac1 Akt1 Hspb1 Pik3r1 Ptk2 Creb1 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor Arrb2 Ar Hdac1 Akt1 Pik3r1 Ptk2 Atf2 Ccne1 Fkbp1a Mapk1 Irf2bp1 Ets1 Dynlrb1 Kpnb1 Mapk3 Ube2i Myc Tp53 Skp1 Pdk1 Ctnna2 Ctnna1 Dcp1a Rbx1 Eid2 Ube2d3 Ube2d2 Ube2d1 Nup153 Sik1 Btrc Cdc25a Atf3 Jund Pxn Sdc2 Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Snx6 Tp73 Jun Cops5 Vdr Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Stk11 Hspa8 Map4k1 Ppp1r15a Wwtr1 Sparc Cdk6 Smad4 Fnta Cdk4 Cul1 Cdc16 Junb Smad6 Daxx Hnf4a Ing2 Xpo1 Pdpk1 Ctcf Foxo4 Tfdp2 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Zeb1 Gsk3b Rbl2 Zeb2 Anapc10 Smurf1 Crk Pik3r2 Stk11ip Nfyb Nfya Ppm1a Nfyc Prkar1b Hoxa7 Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Runx3 Runx1 Cd44 Runx2 Rb1 Tgfbr3 Prkar2a Trim33 Map2k3 Mef2c Brca1 Zfyve9 Cdkn1a Tgfbr2 TCR%NETPATH%TCR TCR Map2k2 Ctnnb1 Dyrk1a Creb1 Akt1 Pik3r1 Ptk2 Atf2 Mapk1 Mapk3 Pxn Gsk3b Crk Pik3r2 Pard3 Prkd1 Prkd2 Eno2 Crkl Cd2ap Acta1 Plcg1 Cblb Plcg2 Ly9 Wipf1 Prkcd Itsn2 Rasgrp1 Rasgrp2 Vasp Arhgef7 Arhgef6 Rasa1 Txk Arhgef2 Unc119 Cabin1 Rps6kb1 Pttg1ip Pik3ap1 Bcl10 Grap Lnpep Lyn Egr1 Nfkbib Fyb1 Tfrc Pik3c2b Cgn Homer3 Nfkbia Crebbp Kirrel1 Slamf6 Cyfip1 Grb2 Ada Ikbkb Itk Gdi2 Enah Tsg101 Dyrk1b Cltc Cd28 Nfkb1 Jak3 Vav3 Rap1a Diaph1 Syk Skap2 Skap1 Gab2 Vav1 Vav2 Bdh1 Ldhb Tuba4a Zdhhc17 Golga5 Ctla4 Cd3g Actr10 Cd3d Dusp3 Pak1 Nfam1 Caskin2 Cct8 Dpysl2 Git2 Ahcy Grap2 Mpzl1 Map2k1 Hnrnph3 Nedd9 Stat1 Dbnl Sh2d3c Mapk8 Tuba1a Sla Map3k8 R3hcc1l Sit1 Dgka Sdcbp Cd86 Cd84 Sh2d2a Cd82 Snrnp70 Cd80 Lax1 Hsp90ab1 Rela Mtmr10 Dok1 Hgs Stk39 Flnb Anxa2 Raf1 Inpp5d Shc1 Stk4 Acly Ripk2 Elmo1 Prp4k Bmf Ptprc Tubb5 Ppp3cb Eprs1 Ptpra Pstpip1 Acbd6 Fer Ogn Cdk1 Lat Itpr1 Zap70 Wdr1 Arhgdib Ddx3x Hdac7 Acp1 Pgm1 Nck1 Nfatc2 Stam2 Anxa11 Adam9 Dnm2 Epha3 Pkm Lck Evl Lcp2 Sos1 Ywhaz Lpxn Atp1a1 Src Atp1a3 Ptpn6 Trim25 Ptpn3 Cbl Cebpb Dock2 Cd2 Muc1 Cd4 Cd5 G6pdx Cd7 Ptpn11 Ptpn12 Mapk14 Arhgap35 Dnajb1 Ptk2b Sh3bp2 Tec Khdrbs1 Ptpn22 Chuk Ran Mapk11 LEPTIN%NETPATH%LEPTIN Leptin Stat1 Rps6kb1 Mapk8 Src Gsk3b Nfkbia Grb2 Ikbkb Ncoa1 Khdrbs1 Shc1 Chuk Runx2 Crp Jak3 Erbb2 Irs1 Pde3a Eif4ebp1 Socs7 Prkaa1 Prkaa2 Gnaq Slc2a4 Esr1 Fyn Jak1 Nos3 Rps6 Cfl2 Egfr Akt1 Eif4e Plcg1 Gsk3a Cdk5 Plcg2 Ptk2 Lep Limk1 Prkce Rps6ka2 Mapk1 Acacb Igf1r KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor Ptpru Gys1 Csf2rb Stat1 Jak2 Sh3kbp1 Mapk8 Mad2l1 Fgr Hck Prkcb Rps6ka1 Kit Gsk3b Tnfrsf10b Prkca Spred1 Ezr Spred2 Crk Grb7 Mtor Epor Mapk12 Yes1 Rela Kitlg Rdx Msn Stat5a Stat5b Fes Cdk2 Raf1 Hras Inpp5d Crkl Akt1 Cblb Pik3r1 Atf2 Wipf1 Mapk1 Rasa1 Sos1 Rps6kb1 Src Grap Ptpn11 Mapk14 Tec Cltc Jak3 Jun Eif4ebp1 Fyn Rps6 Mitf Socs5 Socs4 Matk Socs6 BCR%NETPATH%BCR BCR Nedd9 Stat1 Foxo3 Hck Fos Prkcb Rps6ka1 Gsk3b Crk Pik3r2 Rela Dok1 Bcar1 Cdk2 Cd72 Stap1 Shc1 Elk1 Sla2 Ctnnb1 Chst15 Bank1 Rb1 Nfatc3 Cd22 Malt1 Cycs Plekha1 Hcls1 Prkcq Gtf2i Lat2 Rasgrp3 Prkd1 Blnk Btk Creb1 Pip4k2b Crkl Pip4k2c Itpr1 Zap70 Pip4k2a Akt1 Cd79b Plcg1 Ptpn18 Ccl4 Pik3cg Ptk2 Atf2 Casp7 Mapkapk2 Nck1 Prkcd Casp9 Mapk1 Nfatc2 Sh2b2 Ifitm1 Fcgr2b Cdk7 Bcl6 Btla Rasa1 Bax Lck Stat3 Pip5k1c Hnrnpk Sos1 Pip5k1b Rps6kb1 Itpr2 Bcl10 Ptpn6 Lyn Mapk14 Grb2 Ikbkb Itk Sh3bp2 Tec Chuk Jun Eif4ebp1 Vav1 Fyn Rps6 Map4k1 Gsk3a Junb Pdpk1 TNFALPHA%NETPATH%TNFALPHA TNFalpha Ccnt1 Cyba Diablo Stat1 Rel Tab2 Mapk8 Traf7 Traf4 Mcm7 Map3k8 Pfdn2 Traf6 Faf1 Birc3 Birc2 Ikbkg Csnk2a1 Tnfrsf8 Ywhah Ywhag Mark2 Psmd12 Hsp90ab1 Tnfrsf1b Akt2 Hdac2 Smarcb1 Dok1 Ywhab Psmd13 Alpl Rasal2 Akap8 Psmb5 Rpl8l1 Ppp6c Gab1 Bcl2l1 Rack1 Fkbp5 Rps6ka5 Smarca4 Fadd Mcm5 Ywhae Smpd3 Tnip2 Psmc2 Psmc1 Psmc3 Polr2h Pdcd2 Nsmaf Creb1 Map2k5 Itch Hdac1 Zfand5 Akt1 Cflar Hspb1 Bid Ddx3x Trpc4ap Ptk2 Psmd6 Fancd2 Psmd3 Psmd2 Mapk1 Casp3 Romo1 Elp1 Psmd1 Casp2 Mapk3 Trim32 Ube2i Spag9 Usp11 Glb1 Skp1 Smarcc2 Pdk1 Sos1 Prc1 Ywhaz Smarcc1 Rnf25 Pkn1 Src Lrpprc Map3k11 Ube2d3 Mtif2 Ube2d2 Btrc Ptpn11 Mapk14 Trap1 Irs1 Jun Cav1 Egfr Cul1 Junb Foxo1 Prkca Stat5a Map2k6 Rb1 Gtf2i Casp7 Mapkapk2 Bax Rpl4 Mapk9 Nkiras1 Brinp1 Nr2c2 Nkiras2 Erbb3 Tbkbp1 Trib3 Rps11 Tnf Hsp90aa1 Fbl Ppp1r12a Nfkbia Rpl30 Crebbp Unc5cl Tbk1 Dpf2 Tax1bp1 Grb2 Kcnq1 Polr1b Polr1c Txnip Polr1a Usp2 Xiap Polr1e Fbxw11 Tank Nfkb1 Map3k3 Actl6a Map3k2 Rxra Smarce1 Polr2sl1 Tifa Flna Cdc37 Rffl Inpp5e Rasa3 Nfkbiz Papola Txn Glg1 Bag4 Ripk3 Cradd G3bp2 Dcaf7 Pak1 Cops3 Nfkbie Nlrp4 Kpna6 Mcc Kpna3 Kpna2 Cdk9 Zbtb17 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Fos Prkca Ywhah Pik3r2 Mtor Yes1 Ywhab Shc1 Gab1 Ywhae Ar Akt1 Pik3r1 Pik3cg Ptk2 Prkcd Mapk1 Casp3 Mapk3 Ywhaz Src Clca1 Irs2 Rpsa Rhoa Rac1 Plec Dsp Lama5 Cd151 Itgb4 Lama3 Mst1r Ptpn11 Mylk3 Met Mapk14 Grb2 Pik3r3 Col17a1 Itga6 Ntn1 Ephb2 Lamb2 Lamb3 Sfn Lamb1 Pik3cb Pik3cd Erbb2 Rtkn Irs1 Tp73 Bad Jun Smad2 Eif4ebp1 Smad3 Eif6 Lamc1 Vim Fyn Egfr Eif4e Pak1 WNT%NETPATH%WNT Wnt Csnk1a1 Nlk Lrp5 Gpc3 Dvl3 Mapk8 Wnt2 Wnt1 Tcf7l2 Prkcb Wnt3 Fzd1 Jup Fzd5 Prkca Fzd4 Fzd6 Kremen1 Fzd9 Smad1 Pin1 Mark2 Tcf4 Yes1 Ywhab Prkaca Arrb2 Akt1 Prkcd Nfatc2 Pip5k1b Rhoa Rac1 Jun Ccnd1 Map3k7 Ctbp1 Wnt5a Cdh1 Pi4k2a Ppp1ca Sfrp2 Ppp2ca Sfrp1 Daam1 Cdk6 Dkk1 Mesd Pax2 Prkcg Frzb Dixdc1 Chd7 Axin1 Ror1 Lef1 Lrp1 Arhgef4 IL6%NETPATH%IL6 IL6 Foxo4 Nlk Stat1 Foxo3 Mapk8 Foxo1 Fgr Hck Fos Gsk3b Pik3r2 Map2k2 Socs3 Map3k4 Pias3 Cd40 Sgk1 Il6st Stat5a Map2k6 Il6 Stat5b Il6r Bmx Ncoa1 Map2k4 Shc1 Gab1 Rb1 Btk Ar Hdac1 Akt1 Plcg1 Hspb1 Pik3r1 Prkcd Mapk1 Mapk3 Stat3 Rps6kb1 Lyn Erbb3 Cbl Rac1 Hsp90aa1 Crebbp Ptpn11 Mapk14 Grb2 Ptk2b Nfkb1 Erbb2 Bad Jun Eif4ebp1 Gab2 Map3k7 Vav1 Fyn Jak1 Eif4e Daxx Cdk9 Map2k1 TSH%NETPATH%TSH TSH Gna13 Tshr Hspa5 Canx Gnai2 Gnai1 Atp1a1 Map2k3 Calr Scrib Gnai3 Gnaq Creb1 Lep Ikbkb Map2k6 Igf1r Raf1 Gna12 Gna11 Mapk3 Gnao1 EGFR1%NETPATH%EGFR1 EGFR1 Map2k2 Ywhab Gab1 Rps6ka5 Dyrk1a Creb1 Itch Hdac1 Pik3r1 Ptk2 Mapk1 Myc Tp53 Irs2 Rhoa Rac1 Plec Dsp Jund Itgb4 Met Pik3r3 Dab2 Col17a1 Ephb2 Sp1 Pik3cb Pik3cd Bad Jun Smad2 Smad3 Cav1 Vim Ctbp1 Cdh1 Stk11 Prkcg Arhgef4 Pdpk1 Foxo4 Zfyve16 Foxo1 Fos Jup Gsk3b Crk Pik3r2 Socs3 Map3k4 Pias3 Ap2b1 Map2k3 Scrib App Spart Atf1 Myl12b Pard3 Il17rd Prkd1 Mprip Nedd4 Eno1 Crkl Nectin1 Rps10 Elk4 Plcg1 Gja1 Cblb Tfg Plcg2 Tns4 Scamp3 Tns2 Prkcd Tns1 Itsn2 Ralb Krt8 Otud6b Vasp Cblc Arhgef7 Araf Krt7 Frs2 Frs3 Phlpp1 Actb Actr2 Rps6kb1 Actr3 Pttg1ip Arhgap5 Prkci Arap1 Zdhhc5 Tln1 Lyn Rin1 Pfn1 S100a10 Snca Tfrc Arhgef5 Pik3c2b Hnrnpr Sdc4 Sdc3 Insr Pitpna Kirrel1 Stam Flot1 Atp5f1c Errfi1 Usp6nl Myo6 Slc5a5 Snx5 Tollip Smu1 Dyrk1b Etl4 Cltc Sdc1 Antxr1 Nfkb1 Hip1 Arf4 Braf Adam17 Ptprr Clta Dcbld2 Ptprf Git1 Vav1 Laptm4a Vav2 Cdv3 Plekha6 Cyld Anks1a Mink1 Rplp0 Actn1 Snx33 Actn4 Tkt Baiap2l1 Pak1 Plscr1 Gprc5a Caskin2 Rbck1 Htt Aldoa Git2 Map2k7 Appl2 Stx4 Mpzl1 Rps2 Map2k1 Limd1 Cstb Nedd9 Inppl1 Krt18 Pygb Gsn Mapk8 Pdzd11 Krt17 Ap2s1 Mcf2 Racgap1 Eps15l1 Esyt1 Sdcbp Eppk1 Cttn Axl Ctnnd1 Ensa Stat2 Pkn2 Frk Hipk2 Rela Tjp2 Map3k14 Dok1 Hipk3 Eef1a2 Grb14 Flnb Rictor Grb10 Raf1 Stip1 Cdh2 Plekhn1 Cavin1 Cavin2 Tom1 Cc2d1a Prp4k Cfl1 Prkx Magi1 Hat1 Ap2a1 Pkp2 Ptpra Hnrnpdl Anxa4 Ldlr Pkp3 Anxa1 Cdk1 Vcl Cysrt1 Stambp Pld1 Map4k5 Lpp Ddx3x Rab5a Pld2 Acp1 Ppp1r14b Itga3 Nck1 Pdgfrb Elmo2 Abl2 Slc38a2 Adam9 Dynll1 Tom1l2 Efnb2 Pkm Ptpre Lck Cav2 Tnk2 Ripk1 Sirpa Ywhaz Ralgds Dlg3 Atp1a1 Alb Bcl2 Crim1 Ptpn6 Ddx6 Pdlim1 S100a11l1 Sh3bgrl Cebpb Afap1l2 Rbm3 Tgif1 Sfpq Nck2 Dapp1 Asap1 Slc12a7 Mt-co2 Ptpn12 Baiap2 Mapk14 Sh3gl3 Arhgap35 Lsr Epha1 Ptk2b Epha2 Epn2 Epn1 Khdrbs1 Dyrk4 Epha4 Rps6ka3 Itgb1 Epn3 Erbb2 Dyrk3 Usp31 Elf3 Eif4ebp1 Klf11 Aplp2 Prkaa1 Dsg2 Prkaa2 Ctnnal1 Cd59b Tnip1 Wbp2 Fyn Jak1 Mvp Trim29 Nos3 Eif4g1 Dock1 Egfr Ephb1 Cebpa Gsk3a Ephb3 Cdk5 Phldb2 Ptpn1 Slitrk6 Rgs16 Rps6ka2 Csk Kras Mta2 Arhgap32 Snrpd2 Egf Tagln2 Spry2 Rbbp7 Spry1 Pten Jak2 Reps2 Sh3kbp1 Ralbp1 Bcar3 Spry4 Pebp1 Ptpn23 Rps6ka1 Slc25a5 Kit Hspe1 Arhgap42 Prkca Zpr1 Grb7 Mtor Stat5a Stat5b Cdk2 Hras Elk1 Ptpn18 Pik3cg Casp9 Mapk9 Erbb3 Rpl30 Map3k3 ID%NETPATH%ID ID Rb1 Smad3 Tcf7l2 Rbl2 Psmd4 Fhl2 Rbl1 Id3 Atf3 Map2k2 Hes1 Tcf3 Elk4 Myf5 Mapk1 Cdk2 Raf1 Mapk3 Elk1 Map2k1 IL9%NETPATH%IL9 IL9 Kat5 Stat6 Il9r Stat5a Stat5b Mapk1 Mapk3 IL3%NETPATH%IL3 IL3 Csf2rb Ywhaz Foxo1 Prkcb Ptpn6 Lyn Gsk3b Prkca Crk Pik3r2 Socs3 Socs2 Ywhab Dok1 Bcl2l11 Kcnip3 Rara Fes Slc2a1 Gata2 Hras Inpp5d Shc1 Gab1 Bcl2l1 Prkaca Nfkb1 Rack1 Pik3cd Bad Ptprc Rxra Gab2 Atf1 Creb1 Crkl Ppp2ca Gsk3a Pik3r1 Ptk2 Mapk1 Map2k1 IL5%NETPATH%IL5 IL5 Stat3 Unc119 Stat1 Foxo3 Sos1 Ywhaz Hck Rps6ka1 Lyn Gsk3b Cbl Sdcbp Map2k2 Nfkbia Ptpn11 Mapk14 Grb2 Stat5a Stat5b Ptk2b Raf1 Hras Alox5 Shc1 Pla2g4a Elk1 Il5 Sox4 Ctnnb1 Nfkb1 Rack1 Il5ra Jun Syk Hcls1 Jak1 Crkl Gsk3a Pik3cg Atf2 Prkcd Dnm2 Bax IL4%NETPATH%IL4 IL4 Stat3 Jak2 Rps6kb1 Mapk8 Ptpn6 Irs2 Cbl Cebpb Nfkbia Crebbp Stam Ptpn11 Cd40 Mapk14 Ikbkb Inpp5d Shc1 Elk1 Chuk Nfkb1 Mapk11 Spi1 Pik3cd Il13 Il4 Bad Grk3 Cxcr4 Syk Il13ra1 Snd1 Il2rg Jak1 Cebpa Akt1 Plcg2 Ptk2 Atf2 Prkcd Mapk1 Ets1 Mapk3 Rasa1 IL-7%NETPATH%IL-7 IL-7 Stat3 Stat1 Jak3 Foxo3 Bad Irs1 Foxo1 Il2rg Il7 Irs2 Gsk3b Fyn Map2k2 Akt1 Gsk3a Cblb Pik3r1 Stam Stat5a Mapk1 Stat5b Shc1 Mapk3 Map2k1 NOTCH%NETPATH%NOTCH Notch Stat3 Skp1 Jak2 Src Rbx1 Gsk3b Smad1 Hes1 Tcf3 Hdac2 Rela Nfkb1 Smad3 App Ncstn Aph1b Fhl1 Dll3 Dll4 Maml1 Ring1 Maml2 Akt1 Mfng Furin Pik3r1 Ccn3 Skp2 Jag2 Cul1 Hes6 Mapk1 Maml3 Cirsr Yy1 Psenen Lef1 Notch2 Mapk3 Lfng Psen2 IL2%NETPATH%IL2 IL2 Foxo3 Mapk8 Crk Pik3r2 Mtor Map2k2 Socs3 Rela Sgk1 Stat5a Stat5b Cdk2 Raf1 Shc1 Elk1 Il2rg Creb1 Crkl Akt1 Pik3r1 Pik3cg Atf2 Ccne1 Mapk1 Stam2 Ets1 Mapk3 Il15 Lck Stat4 Il2ra Ybx1 Sos1 Ets2 Plcb1 Tert Nr3c1 Itm2b Bcl2 Ptpn6 Eif3b Il2 Lyn Irs2 Prkcz Cbl Nmi Vil1 Mknk1 Hsp90aa1 Stam Ptpn11 Mapk14 Grb2 Pik3r3 Ptk2b Nfkb1 Pik3cb Jak3 Pik3cd Irs1 Jun Eif4ebp1 Gab2 Vav1 Fyn Jak1 Rps6 Eif4e Map2k1 TSLP%NETPATH%TSLP TSLP Stat3 Stat4 Nfkb1 Stat1 Mapk8 Mapk9 Nfkb2 Nfkbia Eif4e Akt1 Stat6 Rela Mapk14 Stat5a Mapk1 Stat5b Mapk3 Map2k1 RANKL%NETPATH%RANKL RANKL Nfkb1 Spi1 Rel Tab2 Mapk8 Traf6 Map3k7 Nfkb2 Traf3 Tnfsf11 Atp6v1e1 Sqstm1 Tnfrsf11b Ptk2 Trem2 Traf2 Mapk14 Mitf Chuk IL1%NETPATH%IL1 IL1 Rel Tab2 Mapk8 Mapk9 Traf6 Pik3r2 Nfkbia Rela Peli1 Mapk14 Dok1 Map3k14 Ube2v1 Ikbkb Map2k6 Ube2n Irak4 Irak3 Irak2 Irak1 Tollip Pla2g4a Ppp6c Myd88 Sod1 Chuk Il1a Nfkb1 Fbxw5 Rb1 Il1b Peli2 Map3k2 Il1r2 Jun Il1r1 Map2k3 Il1rn Akt1 Pik3r1 Atf2 Mapk1 Elp1 Mapk3 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Hacl2 Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Rpia Gpi Taldo1 Tkt Hk2 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Dhfr Mthfd1l Tyms Mtr Mthfd2 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Galt Aldob Aldoc Aldoa Khk Hk2 Gale P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Atf1 Traf6 Srf Mef2d Elk1 Map3k7 Map2k6 Map3k4 Hspb1 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Mapk11 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Rac2 Akt1 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Pik3cb Nos3 Il10 Ikbkb Spi1 Cxcr1 Stat6 Il15 Irs1 Cxcr2 Stat4 Il13 Il18 Il2ra Irs2 Sla2 Mapk6 Elk4 Pdpk1 Akt3 Myc Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Fos Il20ra Il23a Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Il5ra Sos1 Il6st Shc1 Il10rb Il3ra Mtor Il2 Il4 Il6 Il5 Il7 Il9 Il6r Il21 Il12rb2 Il11ra1 Il4r Mapk15 Spic Srf Il1a Stat5a Elk1 Stat5b Stat3 Stat2 Stat1 Chuk Cdkn1a Cdkn1b Mapkapk2 Mknk2 Mknk1 Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Alad Qars1 Hmbs Fech Eprs1 Cpox Urod Ppox NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Cacna1g Cacna1c Epb41l2 Chrnb4 Clic6 Ppp1r1b Kcnk3 Chrnb3 Chrnb2 Epb41l1 Slc18a2 Adcy2 Drd2 Drd4 Ppp1ca Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 Chrna4 Gnb1 Flna Gnai1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system Per2 Per1 Per3 Cry1 Cry2 Clock Csnk1d Csnk1e Bmal1 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Mvd Fdft1 Lss Fdps Sqle Hmgcs1 Pmvk Ggps1 Hmgcr IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Grin2a Shank1 Shank3 Grm2 Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc17a8 Slc1a6 Slc17a6 Vamp8 Vamp1 Gria4 Vamp3 Gria3 Vamp2 Snap29 Gria2 Snap25 Grik5 Snap23 Stx19 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Stx11 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccnd2 Ccnd3 Ccne1 Cinp P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Pik3cg Pik3cb Pik3cd Pik3c2b Pik3c2a Mapk12 Cdkn1a Mapk13 Mapk14 Hras Mapk11 Pdpk1 Akt3 Ccne1 Pik3c3 Akt2 Ccng1 Ctnnb1 Akt1 Kras Tp53 Tp73 Ppp2cb Rb1 Ppp2ca Pten Pik3c2g Rbl1 Siah1 Nras Cdk2 Pik3r5 Atm Tp63 Atr Pik3r1 Pik3r2 Pik3r3 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Plcd1 Plcb2 Plcd4 Plcb1 Hrh1 Gng3 Gng5 Plcl1 Prkcz Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Itpr1 Plcg1 Gnb1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Plcb4 Prkca Plcb3 Gna11 Gng10 Gna14 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Grin2c Grin2b Grin2a Prkaca Gnaq Grin1 Itpr1 Prkar1b Prkcb Prkx Prkacb Grina Grik5 Grm1 Grm5 Plcb4 Grik1 Gna11 Grin2d OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Txn Pla2g4a Map2k3 Bcl2 Myc Elk1 Map2k6 Stat1 Mapk12 Mapk13 Mapk14 Eef2k Map2k4 Mef2c Mknk2 Mknk1 Mapk9 Jun Mapk8 Mapk11 Max Ddit3 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkx Prkacb Kcnk3 Gnao1 Adcy2 Adcy7 Prkar2a Prkar2b Prkaca Htr1d Kcnk9 Htr1f Gnai2 Htr1b Htr1a Gng11 Gnai3 Gnb1 Gnai1 Gng10 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng5 Plcl1 Prkcz Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Plcg1 Oxtr Gnb1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Plcb4 Prkca Plcb3 Gna11 Gng10 Gna14 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Adcy2 Adcy7 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb1 Htr4 Gnb4 Gnal Gnb3 Gnb5 Gng10 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Prkar1b Prkacb Cacna1g Gnao1 Adcy2 Adcy7 Prkar2a Prkar2b Prkaca Gng11 Gnai3 Gnb1 Gnai1 Cacna1a Cacna1b Gabbr1 Gabbr2 Adcy4 Adcy8 Adcy5 Adcy6 Kcnj3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Ube2n Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2d2 Uba3 Ube2d1 Ube2e2 Ube2g2 Ube2l6 Ube2g1 Ube2a Atg7 Sae1 Ube2l3 Ube2t Ube2s Ube2v2 Ube2k Uba6 Ube2d2b ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway App Erbb4 Apbb3 Nectin1 Trpc6 Afdn Trpc5 Trpc7 Kat5 Wnt5a Trpc1 Cdh1 Trpc4 Wnt5b Wnt9a Kat7 Wnt9b Bace2 Bace1 Wnt10b Acta1 Actb Actr2 Ern1 Ctnnb1 Psenen Notch1 Notch2 Notch3 Psen1 Gsk3b Psen2 Wnt8a Fstl1 Lef1 Wnt11 Ncstn Aph1b Lrp1 Lrp6 Lrp2 Lrp3 Lrp4 Lrp5 Wnt6 Rbpjl Wnt7b Wnt3a Dvl1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Cd44 Actg1 Actg2 Wnt3 Tcf7l2 Fzd1 Actbl2 Actc1 Fzd2 Jup Fzd5 Trim3 Fzd4 Fzd6 Fzd9 Fzd8 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh7a1 Aldh9a1 Aldh1l2 Aldh1b1 Aldh1a2 Aldh1a1 Maob Aldh3a2 Aldh2 Aldh3a1 Aldh1a3 Aldh16a1 Aldh8a1 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Mdm2 Mdm4 Tp63 Tp53 Tp73 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Hacl2 Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss3 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Pank3 Pank4 Pank1 Dcakd METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Ireb2 Aco1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Pik3cg Pik3cb Pik3cd Map2k2 Map2k1 Hras Ikbkb Fos Sos1 Chuk Mapk12 Mapk13 Mapk14 Itpr3 Itpr2 Itpr1 Mapk9 Jun Mapk8 Mapk11 Mapk1 Mapk3 Rac2 Rac1 Nfkbil1 Cd22 Araf Vav3 Syk Plcg2 Vav1 Vav2 Map3k3 Map3k2 Nras Prkcb Blnk Btk Cd79b Prkcd Ptpn6 Lyn Ptprc Ppp3ca Raf1 Ppp3cb Nfkbia Grb2 Mapk10 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Eif4ebp1 Tsc2 Tsc1 Igbp1 Prkaa1 Akt3 Prkab2 Rps6kb1 Akt2 Prkaa2 Prkab1 Prkag1 Akt1 Tp53 Tp73 Ppp2cb Ppp2ca Tp63 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Plcb2 Plcb1 Dagla Lpl Plcb3 Pla1a MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Pmm1 Mpi Gmppa Pmm2 Gmds MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrnp40 Zrsr2 Prpf3 Snrpb2 Snrpa HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Txn Hif1a Akt3 Akt2 Akt1 Rorc Arnt Mtor Txn2 Crebbp Egln2 Egln3 Vhl THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Taf7 Taf6 Gtf2e1 Taf2 Prkar1b Crebbp Gtf2a1l Polr2c Taf1c Taf9 Creb3l3 Creb3l4 Prkar2a Polr2h Prkar2b Polr2e Creb3l1 Ttf2 Creb3l2 Polr2f Taf9b Taf11 Gtf2h1 Psmc3ip Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Tbp Brf1 Tbpl2 Tbpl1 Creb5 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Polr2sl1 Taf8 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Gnao1 Adcy2 Oprd1 Adcy7 Gng3 Pomc Gng5 Gng7 Gnai2 Gng8 Gngt2 Gnai3 Gnb2 Gnb1 Gnb4 Gnai1 Gnb3 Gnb5 Gng10 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b2 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Avp Oxt GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 UNTITLED%PANTHER PATHWAY%P00019 untitled Prkcz Nos3 Map2k2 Map2k1 Akt3 Akt2 Plcb4 Plcb3 Gna11 Gna14 Plcb2 Plcb1 Gnaq Ednrb Ednra Adcy3 Edn1 Edn2 Itpr3 Edn3 Itpr2 Adcy10 Itpr1 Prkar1b Gucy1b1 Prkg2 Prkacb Gucy1a1 Gucy1a2 Mapk1 Pla2g4a Adcy2 Adcy7 Prkar2a Prkar2b Mapk3 Prkaca Akt1 Araf Prkcq Gnal Prkcg Prkch Prkci Adcy4 Prkcb Adcy8 Adcy5 Adcy6 Prkcd Prkce Prkca Raf1 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Dhfr Gch1 Tyms 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng5 Plcl1 Prkcz Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Htr2a Htr2c Htr2b Gng11 Plcg1 Gnb1 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Plcb4 Prkca Plcb3 Gna11 Gng10 Gna14 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Itga2 Itga10 Col4a3 Pxn Arpc3 Col4a1 Cav1 Pik3cg Arpc2 Col4a2 Pik3cb Col8a1 Pik3cd Col4a5 Arpc5 Parvb Pik3c2b Parva Pik3c2a Rap2b Ptk2 Col16a1 Arf1 Map2k2 Col12a1 Itgax Map2k1 Ilk Hras Itgav Rnd2 Rnd3 Rhoa Rnd1 Rhob Itgam Asap1 Itgal Arhgap10 Rap1a Col3a1 Rap1b Itgad Mapk6 Itgb8 Itgb6 Itgb7 Itgb1 Itga2b Actb Itgb4 Rras Itgb2 Actn1 Actn4 Crk Arf6 Arhgap26 Col11a1 Col11a2 Src Dock1 Bcar1 Dnajc27 Sos1 Lamb2 Lamb3 Shc1 Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Col6a2 Ptk2b Lims2 Lamc1 Actg1 Actbl2 Flna Map3k3 Map3k2 Mapk10 Map3k4 Mapk13 Map2k4 Mapk9 Mapk8 Col14a1 Itgbl1 Crkl Arfgap1 Map2k3 Col1a2 Col5a2 Braf Col5a3 Col5a1 Dmbt1 Pik3c3 Mapk3 Col9a2 Col9a1 Arpc1b Rac2 Lama5 Arpc1a Rac1 Lama1 Lama3 Araf Lama4 Flnb Tln1 Vcl Vasp Col17a1 Nras Col13a1 Itga7 Fn1 Itga8 Arl1 Itga5 Itga6 Itga9 Raf1 Itga3 Elmo2 Pik3r1 Itga1 Pik3r2 Elmo1 Pik3r3 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Arhgap8 Shc2 Pik3cg Pik3cb Pik3cd Map2k2 Map2k1 Hras Ikbkb Stat6 Stat4 Arhgap10 Mapk6 Elk4 Pdpk1 Myc Akt2 Jak3 Fos Arhgap26 Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Shc1 Ehf Srgap1 Srgap3 Rab11b Arhgap5 Arhgap4 Mapk15 Erf Erg Arhgap9 Stat5a Shc3 Stat5b Rasa2 Stat3 Rasa1 Stat2 Pdgfrb Stat1 Pdgfra Chuk Pdgfa Pdgfrl Pdgfb Grap Fli1 Rps6kc1 Fev Gabpa Nck2 Jak2 Jak1 Nck1 Arhgap15 Arhgap12 Gab1 Gab2 Etv3 Spdef Elf1 Elf2 Gsk3a Elf3 Elf4 Elf5 Ophn1 Usf2 Grap2 Elp1 Rerg Nin Pkn2 Ninl Arhgap42 Vav3 Vav1 Vav2 Map3k2 Grb2 Mapk10 Rps6kb1 Pik3r5 Srf Elk1 Map3k4 Itpr3 Mapkapk2 Itpr2 Itpr1 Rps6ka5 Mknk2 Mknk1 Jun Mapk8 Mapk1 Braf Ets1 Pik3c3 Mapk3 Plcg1 Araf Plcg2 Nras Arhgap1 Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Myo5c Myo5b Myo1a Myh11 Myo1g Myo1f Plekhh3 Myh10 Myh7b Myo6 Myo18b Myo5a Myo9a Slc5a7 Chrnd Chrne Chrng Chrna2 Chrna1 Myo10 Chrna9 Myo15a Myo16 Myo19 Acta1 Actb Actg1 Actg2 Actbl2 Actc1 Chrnb4 Chrnb3 Chrnb2 Chrna3 Chrna6 Chrna5 Chrna4 Slc44a3 Actr1a Myo3b Chrnb1 Myo7a Slc18a3 Myo7b Slc6a8 Chrna10 Myh2 Myh3 Myh4 Myh7 Myo1c Myo1b Myo1e Myo1d JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Stat6 Jak3 Jak2 Stat5a Jak1 Stat5b Stat3 Stat4 Stat1 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Psat1 Phgdh Psph AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Pik3cg Pik3cb Pik3cd Pik3c2b Pik3c2a Ntn1 Ntn3 Nfatc4 Nfatc3 Nfatc2 Ablim1 Dcc Ntng1 Unc5b Unc5d Unc5c Rac2 Rac1 Plcg1 Plcg2 Vasp Pik3r5 Pik3r1 Pik3r2 Pik3r3 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc18a2 Slc6a19 Slc6a18 Slc6a15 Slc6a20a Slc6a16 Slc18a1 Slc6a2 Slc6a3 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Ugt1a2 Ugt1a3 Inmt Ugt1a5 Ugt2b7 Fmo3 Cyp2a3 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mat2a Mat1a Mtr CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Myh11 Arpc3 Arpc2 Myh10 Myh7b Arpc5 Acta1 Actb Diaph2 Diaph1 Tubb2b Tubb2a Cfl1 Cfl2 Mylk2 Pfn1 Mylk3 Pfn3 Pfn2 Stmn1 Pak1 Pak6 Stmn4 Pak3 Pak2 Actg1 Pak5 Actg2 Pak4 Tubb5 Tubb6 Tubb3 Actbl2 Mylk Actc1 Limk1 Arpc4 Rock2 Tubb4b Rock1 Rac2 Arpc1b Rac1 Arpc1a Myo3b Myh2 Myh3 Myh4 Myh7 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Rps6kb1 Elk1 Rasa1 Map2k2 Map2k1 Ins2 Insr Igf2r Igf2 Igf1 Rps6ka5 Insrr Igf1r Irs1 Irs2 Mapk1 Map2k3 Mapk3 Fos Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Raf1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Jak2 Jak1 Ifngr2 Ifng Ifngr1 Stat1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Upp2 Uprt Nme3 Nme2 Uck1 Uck2 Uckl1 Upp1 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Grin2a Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc1a6 Vamp8 Vamp1 Gria4 Vamp3 Gria3 Vamp2 Snap29 Gria2 Snap25 Grik5 Snap23 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Adcy10 Prkar1b Prkx Prkacb Grm1 Grm5 Prkar2a Prkar2b Cacna1e Prkaca Grm4 Grm7 Gnai2 Grm6 Grm8 Vti1a Gnai3 Slc17a7 Stx1b Gnb1 Cacnb1 Gnai1 Stx1a Cacna1a Cacna1b APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Xiap Endog Rela Map3k1 Apaf1 Tnfrsf10b Lta Pik3cg Fadd Atf7 Pik3cb Ltb Pik3cd Atf6 Casp9 Atf4 Atf3 Jdp2 Aifm1 Map2k7 Gzmf Map4k3 Atf6b Cradd Ikbkb Bak1 Eif2s1 Casp8 Casp7 Prkra Casp3 Bik Ripk1 Map4k2 Diablo Bax Rel Fas Faslg Daxx Map3k14 Akt3 Akt2 Tp53 Fos Atf1 Chuk Igf2r Map2k4 Mapk9 Jun Mapk8 Mapk1 Map2k3 Bcl2 Mapk3 Akt1 Prkcq Atf2 Prkcg Birc3 Prkch Eif2ak2 Birc2 Tnf Prkcb Madd Bcl2l11 Tnfrsf1b Prkcd Tnfrsf1a Tradd Prkce Nfkb2 Prkca Nfkb1 Traf2 Nfkbia Cycs Bcl2l1 Mapk10 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Map3k1 Pik3cg Pik3cb Pik3cd Map2k7 Map2k2 Map2k1 Hras Rhoa Rhob Pdpk1 Tiam1 Akt3 Ralgdsl1 Rala Ralb Exoc2 Pld1 Pld2 Kras Ralgds Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Shc1 Pak1 Pak3 Pak2 Srf Elk1 Stat3 Map2k6 Map3k4 Stat1 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Map2k4 Mapk9 Jun Mapk8 Mapk11 Mapk1 Map2k3 Gsk3a Braf Ets1 Pik3c3 Mapk3 Rac2 Akt1 Rac1 Araf Atf2 Nras Raf1 Grb2 Mapk10 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Plcb2 Plcb1 Gng3 Gng7 Elk1 Gnaq Gng8 Gngt2 Gnb2 Map2k2 Gnb4 Gnb3 Map2k1 Gnb5 Itpr3 Itpr2 Itpr1 Mapk1 Mapk3 Grk3 Gng11 Grk2 Arrb2 Gnb1 Arrb1 Egr1 Agtr1 Agt Prkca Plcb3 Raf1 Gng10 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Taf7 Taf6 Gtf2e1 Taf2 Gtf2a1l Polr2c Taf1c Taf9 Polr2h Polr2f Taf9b Taf11 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Brf1 Tbpl1 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Sirt1 Cdc25c Cdkn1a Crebbp Pdpk1 Mdm2 Akt3 Mdm4 Ccne1 Akt2 Akt1 Tp53 Tp73 Pten Gadd45g Sumo2 Cdk2 Chek2 Sumo3 Atm Gadd45b Tp63 Gadd45a Atr Hdac1 Sfn Cdkn2a Mta2 Traf2 Ccnb1 Gtse1 Cdk1 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Prkcz Vamp8 Vamp1 Vamp3 Vamp2 Snap29 Snap25 Snap23 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Trh Plcd4 Plcb1 Trhr Stx3 Gng3 Cga Gng5 Cacnb3 Plcl1 Cacnb4 Gng7 Cacnb2 Gnaq Tshb Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Cacna1e Plcg1 Gnb1 Prkcq Cacnb1 Plcg2 Cacna1a Prkcg Cacna1b Prkch Prkci Prkcb Prkcd Prkce Prkca ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b2 Lipa Cyp19a1 Hsd17b7 Hsd17b6 Soat2 Hsd17b3 Soat1 Hsd17b1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10b Acta1 Actb Actr2 Wnt8a Fstl1 Lef1 Wnt11 Wnt6 Wnt7b Wnt3a Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Actg1 Actg2 Wnt3 Tcf7l2 Fzd1 Actbl2 Actc1 Fzd2 Fzd5 Fzd4 Pcdhb2 Fzd6 Pcdhb1 Fzd9 Cdh9 Fzd8 Cdh8 Cdh7 Cdh6 Cdh5 Pcdhgb7 Pcdh10 Cdh2 Pcdh19 Pcdh18 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhb22 Pcdhac2 Cdhr2 Pcdha13 Cdhr1 Pcdha10 Pcdha11 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ptpn1 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Ctnnd2 Pcdhga2 Ctnnd1 Pcdhga3 Ctnnb1 UNTITLED%PANTHER PATHWAY%P06664 untitled Rela Tgif1 Skil PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Aco2 Sdhc Pdk2 Cs Fh Pdha2 Suclg1 Mdh1 Ogdh ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Odc1 Azin1 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Aldh6a1 Dpys Dpyd Dpysl2 Abat Dpysl3 Cda Upb1 Dpysl5 Nt5e ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Adcy2 Adcy7 Prkar2a Gng3 Prkar2b Gng5 Prkaca Gng7 Gng8 Gngt2 Gnb2 Gnb1 Gnb4 Gnal Gnb3 Gnb5 Adrb1 Prkx Prkacb Gng10 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Tsc2 Tsc1 Gsk3a Pdpk1 Mdm2 Mdm4 Foxo3 Gsk3b Pten Ins2 Insr Igf2r Igf2 Foxo1 Igf1 Insrr Igf1r Irs1 Irs2 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Adcy2 Adcy7 Prkar2a Gng3 Prkar2b Gng5 Prkaca Gng7 Gng8 Gngt2 Gnb2 Gnb1 Gnb4 Gnal Gnb3 Gnb5 Prkx Hrh2 Prkacb Gng10 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Adcy2 Adcy7 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb1 Gnb4 Gnal Gnb3 Gnb5 Adrb3 Gng10 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Ampd3 Gda Xdh Nt5e METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Gng3 Pomc Gng5 Gng7 Gnaq Gng8 Gngt2 Gnb2 Gnb1 Gnb4 Gnal Gnb3 Gnb5 Crh Crhr2 Gna11 Crhr1 Gng10 Gna14 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Klc1 Adam17 Mapk4 Klc4 Klc3 Klc2 Mapk15 Apba1 Prkcz Apba2 Cacnb2 Apba3 Pkn1 Mapk12 Mapk13 App Mapk14 Cacna1c Kat5 Mapk9 Mapk8 Mapk11 Mapk1 Mapk6 Bace2 Bace1 Mapk3 Psenen Pkn2 Psen1 Psen2 Cacnb1 Prkcq Prkcg Prkch Ncstn Prkci Aph1b Prkcb Prkcd Prkce Prkca Cacna1f Cacna1d Mapk10 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Dcc Srgap1 Ntng1 Rac2 Cxcl12 Rac1 Slit1 Slit2 Slit3 Robo1 Cxcr4 Abl1 Ntn1 Ntn3 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Dscaml1 Nme3 Dhodh Nme2 Cad Ctps2 Cps1 Ctps1 Nme1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Shc2 Pik3cg Prkcz Pik3cb Pik3cd Pik3c2b Pik3c2a Map2k7 Map2k2 Map2k1 Erbb4 Hras Stat6 Stat4 Akt3 Akt2 Rras Sos1 Pik3r5 Shc1 Stat5a Shc3 Stat5b Rasa2 Stat3 Rasa1 Map2k6 Stat2 Map3k4 Stat1 Mapk12 Mapk13 Grap Mapk14 Map2k4 Erbb2 Erbb3 Mapk9 Mras Rasal2 Gab1 Mapk8 Gab2 Egfr Mapk11 Phldb2 Prkd3 Nf1 Mapk1 Rras2 Dab2ip Map2k3 Prkd1 Spry2 Braf Spry1 Prkd2 Spry4 Pik3c3 Mapk3 Rac2 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Map3k3 Prkci Map3k2 Nras Prkcb Prkcd Prkce Prkca Raf1 Mapk10 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Serpinb2 Fgb Fga Mmp13 Mmp1 Plau Fgg Serpinf2 Plat Plg Serpine1 Mmp9 PNAT%PANTHER PATHWAY%P05912 PNAT Stx3 Gng3 Gng8 Gnb2 Vamp8 Gnb4 Vamp1 Gnb3 Vamp3 Vamp2 Snap29 Prkx Prkacb Snap25 Snap23 Epb41l2 Clic6 Ppp1r1b Kcnk3 Epb41l1 Slc18a2 Adcy2 Drd2 Adcy7 Drd4 Prkar2a Ppp1ca Prkar2b Prkaca Kcnk9 Gnai2 Epb41 Slc6a3 Gng11 Gnai3 Gnb1 Flna Gnai1 Epb41l3 Drd1 Drd5 Ppp1cc Gnaz HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Shh Smo Ptch1 Sufu Crebbp Stk36 Fbxw11 Gli1 Btrc MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Kcnj5 Chrm2 Chrm4 Gnat2 Gnat1 Gng3 Gng5 Gng7 Gng8 Gngt2 Slc5a7 Gnb2 Gnb4 Gnb3 Gnb5 Adcy10 Prkar1b Prkx Prkacb Gnao1 Prkar2a Prkar2b Prkaca Gnai2 Gng11 Gnai3 Gnb1 Gnai1 Slc18a3 Slc6a8 Kcnj3 Gng10 Kcnj9 Kcnj6 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Amdhd2 Gnpda2 Npl Gfpt1 Gfpt2 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Bmp10 Bmp8a Bmp15 Dcp1b Lefty2 Acvr1 Foxh1 Smurf1 Jund Acvr1c Snip1 Hras Lefty1 Tgfb2 Tgfb3 Gdnf Skil Cited1 Acvrl1 Cited2 Acvr1b Crebbp Amhr2 Fosl1 Mstn Gdf2 Bmpr1a Gdf3 Gdf6 Bmp7 Bmp6 Bmp5 Gdf7 Bmp4 Rras Bmpr2 Smad1 Bmp3 Smad2 Gdf9 Nodal Bmp2 Smad3 Smad4 Bmp1 Smad9 Acvr2a Tll2 Gdf15 Inhba Inhbb Acvr2b Junb Inhbc Tgfbr1 Smad5 Tgfbr2 Smad6 Inhbe Smad7 Gdf11 Gdf10 Map3k7 Mapk12 Mapk13 Mapk14 Mapk9 Jun Mapk8 Mapk11 Mapk1 Mapk3 Atf2 Nras Mapk10 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation F2r Kng2l1 Klkb1 Gp5 Proc Gp9 Gp1bb F13b Gp1ba Procr Vwf F10 F12 Proz Tfpi F2 Serpina10 F3 Thbd F7 F8 F9 Pros1 Fgb Itga2b Fga Plau Fgg Plat Plg PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Gnat2 Rps6kb1 Pik3cb Gnaq Casp9 Gngt2 Nos3 Gnb2 Gnb4 Gnb3 Gnb5 Insr Irs1 Ptger1 Foxo4 Gngt1 Ywhaz Pdpk1 Akt3 Akt2 Foxo3 Gnai2 Akt1 Gnai3 Gsk3b Gnb1 Gnai1 Nras Sos1 Foxo1 Pik3r5 Gna11 Pik3r1 Pik3r2 Gna14 Pik3r3 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Kcnj5 Chrm2 Chrm4 Rap1a Rap1b Gsk3b Gngt1 Adora2b Adora2a Adra2c Adra2b Htr6 Htr7 Gsk3a Oprl1 Adcy2 Phka1 Drd2 Phka2 Drd4 Adrb2 Adra1b Prkaca Adra1a Adra1d Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Gnb1 Oprm1 Htr5a Gnai1 Phkb Chrm1 Chrm3 Chrm5 Hrh4 Hrh3 Adora1 Gnrhr Gys1 Gys2 Clta Cltb Cltc Mtnr1a Creb1 Creb3 Phkg1 Phkg2 Mtnr1b Pygb Pygl Grm2 Gpr50 Oprk1 Crebbp Creb3l3 Creb3l4 Creb3l1 Creb3l2 Adrb1 Hrh2 Adrb3 Creb5 Gng10 Oprd1 Hrh1 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Adcy3 Prkar1b Prkacb Grm1 Grm5 Htr2a Htr2c Htr2b Adcy7 Prkar2a Prkar2b Htr1d Grm4 Htr1f Grm7 Gnai2 Grm6 Htr1b Grm8 Htr1a Gnai3 Htr4 Gnal Drd1 Drd5 Adcy4 Adcy8 Adcy5 Adcy6 Kcnj3 Kcnj9 Kcnj6 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Pik3cg Prkcz Map3k6 Pik3cb Frs2 Pik3cd Frs3 Fgfr3 Pik3c2b Fgfr4 Pik3c2a Fgfr1 Fgfr2 Map2k7 Map2k2 Map2k1 Hras Akt3 Akt2 Sos1 Shc1 Shc3 Rasa2 Rasa1 Map2k6 Map3k4 Mapk12 Mapk13 Grap Mapk14 Map2k4 Mapk9 Mapk8 Mapk11 Mapk1 Map2k3 Spry2 Spry1 Spry4 Pik3c3 Mapk3 Rac2 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Map3k3 Prkci Map3k2 Nras Prkcb Prkcd Ptpn6 Prkce Prkca Raf1 Mapk10 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Ass1 Otc Cad Cps1 Asl HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Gnat1 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb5 Cnga3 Pdc Cnga1 Grk1 Rho Calml3 Rgs9 Cngb1 Pde6a Gngt1 Pde6b Cngb3 Rcvrn Gng13 Gnb1 Gng10 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Mapk15 Elk1 Mapk12 Mapk14 Mapk9 Ywhaz Mapk8 Psma4 Psma3 Mapk1 Psma6 Psma5 Ccne2 Psma2 Psma1 Ccne1 Cask Ywhah Mapk3 Ywhag Ywhae Pld2 Th Ywhab Psmb10 Slc6a3 Sncaip Psmb7 Prkn Psmb1 Gpr37l1 Septin5 Psmb3 Stx7 Septin2 Septin1 Gpr37 Stx12 Ndufv2 Sfn Snca Mapk10 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Grin2a Gng3 Gng5 Prkcz Gng7 Gnaq Pkn1 Gng8 Grin1 Gngt2 Slc5a7 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Itpr1 Grin2d Grin2c Grin2b Pkn2 Gng11 Gnb1 Prkcq Prkcg Chrm1 Prkch Chrm3 Prkci Slc18a3 Prkcb Prkcd Prkce Plcb4 Prkca Gna11 Gng10 Gna14 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Adcy2 Oprd1 Adcy7 Gng3 Gng5 Gng7 Gnai2 Gng8 Gngt2 Gnai3 Gnb2 Gnb1 Gnb4 Gnai1 Gnb3 Gnb5 Pdyn Penk Gng10 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Rfc3 Rfc4 Pcna Rfc1 H3f3b Rfc2 Rpa2 Top1 Dna2 Rfc5 Pold2 Pold1 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Pccb DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Nme3 Nme2 Adsl Rrm2 Impdh2 Rrm2b Gmps Ak3 Ak2 Ak4 Adss2 Dscaml1 Atic Nme7 Ppat Nme6 Guk1 Gart Nme1 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Rxra Vdr F13b Rara Gc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Chrm2 Chrm4 Grm2 Prkcz Oprk1 Rhoa Rap1a Gng13 Rap1b Dnajc27 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Oprd1 Gng3 Gng5 Gng7 Gnaq Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Itpr3 Itpr2 Itpr1 Grm1 Grm5 Gngt1 Rap1gap Adora2b Rasgrp3 Adora2a Rasgrp4 Rasgrp1 Rasgrp2 Arhgef1 Bdkrb2 Oprl1 Gnao1 Bdkrb1 Gpr45 Drd2 Drd4 Cacna1e Grm4 Grm7 Grm6 Sstr5 Grm8 Sstr4 Sstr3 Sstr2 Sstr1 Gnb1 Prkcq Oprm1 Cacna1a Prkcg Cacna1b Prkch Chrm1 Drd1 Prkci Chrm3 Drd5 Chrm5 Prkcb Adora1 Gnrhr Prkcd Prkce Clta Prkca Cltb Cltc ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Lpxn Arhgap8 Shc2 Map3k1 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Rhoa Rhob Wnt5a Wnt5b Akt3 Wnt10b Akt2 Pld1 Pld2 Notch1 Fos Notch2 Crk Gsk3b Src Sos1 Shc1 Rbpjl Wnt7b Dvl1 Dvl3 Wnt7a F2r Wnt2 Wnt1 Tcf7l2 Stat3 Rasa1 Fzd1 Pdgfrb Stat1 Pdgfra Pdgfa Fzd2 Pdgfb Fzd5 Grap Nck2 Jak1 Nck1 Frs2 Frs3 Fgfr1 Ctnnb1 Pak1 Pak3 Pak2 Hspb1 Mapkapk3 Mapk14 Mapkapk2 Map2k4 Jun Mapk8 Prr5 Prkd3 Mapk1 Crkl Pla2g4a Prkd1 Braf Prkd2 Grb14 Ets1 Fgf1 Pik3c3 Mapk3 Dok1 Dok3 Cryab Axin1 Akt1 Grb7 Pdgfc Sh2d2a Tcf7 Plcg1 Efnb1 Araf Jag2 Prkcq Efnb2 Plcg2 Jag1 Prkcg Pla2g4d Prkch Angpt1 Prkci Apc2 Nras Epha3 Prkcb Ephb1 Sphk2 Ephb2 Arhgap1 Dll1 Prkcd Ephb3 Sphk1 Dll3 Prkce Dll4 Prkca Dlk1 Raf1 Apc Pik3r1 Pik3r2 Pik3r3 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Dscaml1 Nme3 Nme2 Nme1 Rrm2 Tyms Rrm2b SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Syt1 Syt11 Syt12 Syt7 Syt6 Unc13c Rab3a Stxbp1 Unc13b Syt15 Stx2 Unc13d Stx1b Vamp1 Stx1a Snap25 Syt5 Syt3 Syt2 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Pxn Pik3cb Nr2c2 Clu Ier3 Ptk2 Rps6 Map2k2 Sp1 Sp3 Map2k1 Elavl1 Akt1s1 Itgav Yes1 Snai1 Tcf4 Rhoa Hbegf Nos1 Irs1 Hdac7 Casp3 Akap1 Cckbr Cdh1 Pparg Gucy2e Arhgef28 Bax Cd38 Ptgs2 Camk4 Elk4 Map2k5 Pdpk1 Ptpn11 Map3k14 Itgb1 Tpcn1 Bad Cck Gast Foxo3 Map3k11 Fos Crk Gsk3b Arrb2 Rps6ka3 Egr1 Src Rps6ka1 Bcar1 Sos1 Shc1 Ptk2b Stat3 Jak2 Slc18a2 Prkaca Gnb1 Lyn Ppp3ca Nfkbia Grb2 Creb1 Mapk10 Eif4ebp1 Rps6kb1 Nfatc2 Odc1 Ctnnb1 Ywhab Foxo1 Pak1 Traf6 Srf Mef2d Elk1 Map2k6 Hspb1 Mapk14 Rock1 Itpr1 Eif4e Map2k4 Prkacb Mef2c Mapk9 Jun Mapk8 Mapk1 Pla2g4a Prkd1 Bcl2 Braf Prkd2 Mapk3 Plau Akt1 Rac1 Plcg1 Araf Prkcq Atf2 Prkch Prkcb Prkcd Prkce Prkca Raf1 Pik3r1 Bcl2l1 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Aldoa Pklr Eno1 Bpgm Eno2 Pfkl Pkm Pgk1 Pgam2 Tpi1l2 Pfkm Gpi Hk2 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Jag1 Maml1 Numb Cirsr Dll3 Dll4 Notch1 Notch2 Dlk1 Rbpjl Notch3 Jag2 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Csad Gad1 Gad2 Abat FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Gsn Casp6 Capg Scin Apaf1 Dffb Fadd Casp9 Map2k4 Casp8 Casp7 Casp3 Mapk9 Jun Mapk8 Fas Faslg Daxx Faf1 Parp3 Parp2 Parp1 Cflar Lmnb1 Lmnb2 Mapk10 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Rela Arpc3 Pik3cg Arpc2 Prkcz Pik3cb Pik3cd Arpc5 Jund Col12a1 Ikbkb Cxcr1 Rhoa Cxcr2 Itgal Pdpk1 Itgb7 Akt3 Itgb1 Acta1 Akt2 Actb Rras Sos1 Shc1 Junb Il2 Col6a2 Ptk2b Cxcr3 Cxcr5 Cxcl10 Actg1 Fpr1 Actg2 Fpr3 Ccr10 Stat3 Ccr1 Xcr1 Vwf Actbl2 Ccrl2 Actc1 Chuk Ltb4r2 Rhog Ccr9 Grap Ccr8 Ccr7 Ccr6 Ccr5 Ccr4 Ccr3 Jak2 Ccr2 Cx3cr1 Ifnar1 Camk2d Ccl11 Ccl12 Ccl7 Camk2a Ccl5 Ccl4 Ccl3 Ccl2 Adcy2 Pf4 Prex1 Cx3cl1 Nfat5 Prkaca Ccl22 Ccl20 Ccl21 Gnai1 Myo3b Vav1 Myh2 Myh3 Myh4 Myh7 Myh11 Myh10 Myh7b Nfatc4 Nfatc3 Nfatc2 Cask Kras Plcb4 Mylk2 Plcb3 Gna11 Mylk3 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Pak1 Plcb1 Pak6 Gng3 Pak3 Gng5 Pak2 Plcl1 Pak5 Gng7 Pak4 Gnaq Gng8 Plcz1 Mylk Plce1 Arpc4 Cxcr4 Gnb3 Rock1 Itpr3 Itpr2 Itpr1 Prkx Prkacb Ifng Jun Col14a1 Mapk1 Gnao1 Mapk3 Arpc1b Rac2 Gnai2 Akt1 Arpc1a Rac1 Plcg1 Gnai3 Araf Plcg2 Nras Prkcb Adcy5 Adcy6 Prkce Nfkb2 Raf1 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Gda Prtfdc1 Pnp Hprt1 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Dync1li1 Dnai2 Dynll1 Grin2a Dynll2 Apaf1 Capn9 Cyc1 Capn5 Capn7 Capn6 Capn1 Grin1 Capn3 Arpc5 Capn2 Dlg4 Dnah5 Dnah8 Map2k7 Cyfip1 Sp1 Capns1 Capn11 Capn12 Casp8 Grik5 Casp3 Crebbp Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Acta1 Actb Actr2 Tp53 Fos Tp73 Tbp Tp63 Tubb2b Tubb2a Actg1 Actg2 Tubb5 Tubb6 Tubb3 Actbl2 Actc1 Rhog Tubb4b Map2k4 Mapk9 Map3k10 Jun Rac2 Arpc1b Rac1 Arpc1a Hip1 Bdnf Ift57 Dync1h1 Dnal4 Dctn1 Rhoj Rhoq Dync1i2 Dync1i1 Ap2a2 Ap2a1 Hap1 Hip1r Kalrn Cltb Htt Gapdhs Dync1li2 Dync2h1 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Acly Pc Me1 Clybl Pck1 Pklr Cs Pdha2 Pkm T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Map3k1 Pik3cg Pik3cb Pik3cd Map2k2 Map2k1 Hras Ikbkb Zap70 Cd28 Cd86 Cd80 Lck Lcp2 Cd3g Cd247 Cd3d Ppp3cc Lat Akt3 Akt2 Fos Sos1 Pak1 Pak3 Pak2 Chuk Itpr1 Nck2 Nck1 Mapk9 Jun Mapk8 Mapk1 Braf Pik3c3 Mapk3 Grap2 Akt1 Rac1 Plcg1 Araf Vav3 Prkcq Vav1 Vav2 Nras Ptprc Ppp3ca Raf1 Ppp3cb Pik3r1 Nfkbia Pik3r2 Pik3r3 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Traf6 Elk1 Map3k7 Chuk Map2k2 Mapk14 Map2k1 Ikbkb Mapk9 Jun Mapk8 Map2k3 Map3k8 Tbk1 Ticam2 Mapk3 Irak4 Ecsit Nfkbie Tollip Irak1 Tlr10 Myd88 Tank Irf3 Tlr7 Tlr6 Tirap Tlr4 Tlr3 Tlr2 Nfkbia VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Psat1 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10b Arrb2 Wnt8a Arrb1 Fstl1 Lef1 Wnt11 Lrp6 Hdac1 Lrp5 Wnt6 Wnt7b Wnt3a Dvl1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd2 Fzd5 Fzd4 Pcdhb2 Fzd6 Pcdhb1 Fzd9 Fzd8 Cdh9 Cdh8 Cdh7 Cdh6 Cdh5 Pcdhgb7 Pcdh10 Cdh2 Pcdh19 Pcdh18 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fat2 Fat1 Fat3 Pcdhb22 Pcdhac2 Cdhr2 Ppp3ca Pcdha13 Ppp3cb Cdhr1 Pcdha10 Pcdha11 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Pcdhga2 Pcdhga3 Crebbp Ppp3cc Arr3 Smarce1 Srcap Tbl1x Nlk Kremen2 Kremen1 Siah2 Ino80 Ep400 Hells Hltf Csnk1a1 Ppp2r5d Smarcal1 Ppp2r5c Ppp2r5b Ppp2r5a Ankrd6 Ppp2r5e Chd1l Arid1a Pygo2 Pygo1 Tle4 Tle3 Tle2 Tle1 Ctnna2 Ctnna1 Csnk1g3 Hdac3 Hdac2 Csnk1g2 Tbl1xr1 Smarcb1 Hdac8 Csnk2b Smarca2 Sag Smarca1 Smarca4 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd3 Smarcd2 Smarcc2 Smarcc1 Prkcq Prkcg Prkch Prkci Prkcb Prkcd Prkce Prkca Fbxw11 Btrc Prkcz Smad1 Gsk3b Smad4 Smad5 Gnb1 Csnk1d Csnk1e Nfatc4 Nfatc3 Gng13 Nfatc2 Ctnnb1 Ppp2cb Ppp2ca Siah1 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Gng3 Gng5 Gng7 Gnaq Gng8 Gnb2 Gnb4 Gnb3 Itpr3 Itpr2 Itpr1 Axin1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Ada Prtfdc1 Xdh Pnp Hprt1 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Gnat2 Gng3 Grm2 Gng5 Gng7 Gng8 Gngt2 Gnb2 Vamp8 Gnb4 Vamp1 Gnb3 Gnb5 Vamp3 Adcy10 Vamp2 Prkar1b Snap29 Prkx Prkacb Snap25 Snap23 Gnao1 Prkar2a Prkar2b Cacna1e Prkaca Gnai2 Gng11 Gnai3 Stx1b Gnb1 Cacnb1 Stx1a Gnai1 Cacna1a Cacna1b Gng10 UNTITLED%PANTHER PATHWAY%P05916 untitled Gnao1 Adcy2 Adcy7 Gng3 Gng5 Oprk1 Gng7 Gnai2 Gng8 Avp Gngt2 Oxt Gnai3 Gnb2 Gnb1 Gnb4 Gnai1 Gnb3 Gnb5 Pdyn Gng10 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Arhgef1 Pak1 Rac2 Dpysl2 Nrp1 Rac1 Dpysl4 Plxnb1 Dpysl5 Sema3a Sema4d Cdk5 Dpys Fes Crmp1 Frk Rhoa Fyn ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Plcb2 Gnao1 Plcb1 Gng3 Gng5 Gng7 Gng8 Gngt2 Gng11 Gnai3 Gnb2 Gnb1 Gnb4 Gnai1 Gnb3 Cacna1a Cacna1b Cnr1 Cacna1g Grm1 Grm5 Plcb3 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Taf1c Rrn3 Tbp Polr1b Taf1a Tbpl2 Cavin1 Tbpl1 Taf1b Ubtf Taf8 Psmc3ip PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Cda BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Adcy2 Adcy7 Prkar2a Gng3 Prkar2b Gng5 Adrb2 Prkaca Gng7 Gng8 Gngt2 Gnb2 Gnb1 Gnb4 Gnal Gnb3 Gnb5 Prkx Prkacb Gng10 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Oprd1 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkx Prkacb Gnao1 Adcy2 Adcy7 Prkar2a Prkar2b Prkaca Gnai2 Gnai3 Gnb1 Oprm1 Gnal Gnai1 Pdyn Penk Gng10 Creb1 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Adra2b Plcb2 Plcb1 Adra1b Adra1a Plce1 Prkcg Itpr1 Prkcd Prkce Plcb4 Prkca Plcb3 Gna11 Adra2c LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Gch1 Akr1b1 Pts TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Ren1 Ace ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Egln3 Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Slc25a10 Idh1 Idh2 Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 Egln2 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Abat Acss1 Acat1 Acaca Dld Acss3 Mlycd Bckdha Aldh6a1 Pccb Dbt Acadm ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway P2ry2 Ptk2b Prkca THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Cant1 Galt Nme2 Slc2a1 Lalba G6pc1 B4galt1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Map3k1 Cd40 Mapk14 Traf3 Dusp1 Cd40lg Elp1 Ikbkg Chuk Ikbkb INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Pikfyve Ipmk Impa1 Mtor Pik3r4 Itpka Miox Vac14 Becn1 Ptpmt1 Sacm1l Inpp4a TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Rpia Prps1 Pfkl G6pdx Taldo1 Tkt Fbp1 Rbks CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Ren1 Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Amy1 Ugdh Pgm1 Gusb Pgm2l1 Gys1 Pygl LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Idh1 Gls2 Idh2 Idh3a D2hgdh Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gusb Ugt8 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Elk1 Map3k1 Cd3d Rela Mapk3 Nfat5 Lck Ubc Grb2 Rasgrp1 Rac1 Lat Hras Prkca Ppp3ca Jun Mapk8 Ppp3cb Shc1 Ptpn7 Cd3g Cd247 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Ndufs2 Ndufs7 Akr1a1 Xdh Abcb1a Abcg2 Cbr3 Akr1c18 Ralbp1 Nqo1 Por Nos3 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugdh Gusb Hk2 Pgm2l1 Pygl RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Gls2 Dld Hal Sds Aqp8 Asrgl1 Amt Cps1 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Rela Mapk3 Prkca Cacna1d Mapk1 Cacna1c Hras Itpr1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Cacnb1 Cacna1a Slc2a2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Prkca Gnaq Itpr1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Uap1 Gfpt1 Pgm3 Renbp Npl Nans Cmas Chit1 Nanp Hexa Gnpnat1 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Inpp5d Erbb2 Pik3c2a Pten Pik3c3 Vac14 Egfr Becn1 Fig4 Ambra1 Pik3cd Pikfyve Pip4k2a Pik3r4 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Pgm1 Rpia Rpe Pgls Pfkl Prps1l1 G6pdx Taldo1 Tkt Fbp1 Rbks SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Mat2a Amd1 Srm ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Ren1 Ace MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Pmm1 Sord Fbp1 Khk ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Rrm2b Slc28a3 Slc29a1 Ctps1 Dck Nme1 Dctd PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Pdia2 Sdf2l1 Ugt1a6a Pdia4 Dnajb11 Hspa5 Ephx1 Cyp1a2 Nqo1 Cyp2e1 Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Comt Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Cyp2c11 Kcnj11 Abcc9 Ugt1a9 Erp29 Ugt1a5 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Cant1 Galt Nme2 Slc2a1 Lalba G6pc1 B4galt1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Itpa Tymp Cda Dpys Ak3 Nme6 Upp2 Dpyd Uckl1 Rrm2b Cant1 Ctps1 Dctd SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Acadl Acat1 Hadh Acss3 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Sult1a1 Fmo1 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Qars1 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Abcb1a Abcc3 Cdkn1a Tp53 Ralbp1 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Pdia2 Sdf2l1 Pdia4 Dnajb11 Hspa5 Dhrs4 Cyp3a9 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Aldh1a1 Rdh16 Rpe65 Cyp26a1 Dgat1 Retsat Cyp2a3 Dhrs9 Cyp3a73 Erp29 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Abcd2 Aldh3a2 Abcd1 Phyh MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Ren1 Ace DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Itpa Tymp Cda Dpys Ak3 Nme6 Upp2 Dpyd Uckl1 Rrm2b Cant1 Ctps1 Dctd DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Dct Tyr PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Got1 Pah Tat Yars1 Fah Farsa Hpd Farsb NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Rpe Taldo1 Aldob Rbks Fbp2 H6pd Prpsap1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Pgam2 Pklr Tpi1l2 Hk2 G6pc1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Pmm1 Sord Fbp1 Khk AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Ren1 Ace INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Adcy2 Creb1 Fshr Prkacb Ppp1ca Gnb1 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Th Ddc GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 Pgs1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Slc22a1 Ugt2b7 Cyp2d4 Ugt1a9 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Npr1 Clock Csnk1e CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Elk1 Map3k1 Mapk3 Nfat5 Lck Lyn Grb2 Orai1 Blnk Rac1 Hras Prkca Ppp3ca Jun Mapk8 Ppp3cb Shc1 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Chrm1 Gnaq Gnb1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl23 Rplp1 Rpl13a Rpl35a Fau Eprs1 Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Farsa Uba52 Rpl26 Farsb Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Ren1 Ace GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Pgam2 Pklr Hk2 Slc2a2 Bpgm Pgk1 G6pc1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Pdia2 Sdf2l1 Ugt1a6a Pdia4 Dnajb11 Hspa5 Cyp1a2 Abcc4 Abcc5 Cyp2e1 Gstp1 Ugt2b35 Gstt1 Abcb1a Cyp2a3 Sult1a1 Abcg2 Cyp2d4 Ugt1a9 Erp29 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Dld Sds Bckdha Pccb Dbt METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Slc46a1 Mthfd1 Mthfd2 Mthfs Ftcd Mthfr CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Cyp2c11 Alox15b Ptgs2 Cyp2d4 Ugt1a9 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Aars1 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Abcb1a Abcc3 Cdkn1a Tp53 Ralbp1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Pla2g2a Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Cycs Ndufa1 Atp5f1d Uqcrc1 Atp5pb Atp5mc2 Atp5f1b Atp5f1a Gpd2 Slc25a4 Sdhc Sdhb Sdha VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Ggcx Vkorc1 Nqo1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Scn1b Cyp1a2 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Btd Hlcs CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Ren1 Ace OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Pgm1 Akr1b1 Galt Glb1 Lct G6pc1 B4galt1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Aldh3a1 Cyp2e1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Ip6k1 Ipmk Inpp5j Impa1 Itpka Itpk1 Ippk Inpp4a Bpnt1 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Acat1 Hadh Hmgcl Oxct1 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Mvd Acat1 Fdps Idi1 Lss Pmvk BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Tpi1l2 Pfkp GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Prps1 Pfkl G6pdx Taldo1 Tkt Fbp1 Rbks PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Agpat1 Ptpmt1 Pgs1 Gpam Gpd1 Crls1 Cds1 Gpd2 Pla2g2d Ptdss1 Ptdss2 Pisd Phospho1 Pld2 Pcyt1a Pla2g15 Lypla1 Dgka FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C3 C5 C6 C7 Cfb NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Cyp2c11 Cyp2d4 Cyp3a73 Slc6a4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Sphk2 Cerk Ugt8 Sptlc2 Degs2 Samd8 Ugcg HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Gch1 Akr1b1 Pts CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Cat Sod3 Sod2 Sod1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Pdia2 Sdf2l1 Pdia4 Dnajb11 Abcb1a Hspa5 Abcg2 Cyp3a73 Ugt1a9 Erp29 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Ren1 Ace WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Mpc1 Aco1 Slc2a13 Bpgm Pdhx Slc16a1 Aldoc Idh1 Gls Acly Rpia Idh3a Ireb2 Ogdh Pgk2 Taldo1 Sdhc Sdhb Sdha Cs H6pd PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Abcb1a Abcc3 Cdkn1a Tp53 Ralbp1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Mapk3 Grb2 Hras Prkca Insr Mapk1 Ptpn6 Ghr Shc1 Stat5a Stat5b Slc2a4 Sos1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Aqp3 Aqp2 Atp6v1b1 Ca1 Slc4a1 Atp1b1 Atp1b3 Scnn1b Atp1b2 Scnn1g Ren1 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd1 Gpd2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Gch1 Akr1b1 Pts 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3r4 Vac14 Pik3c3 Prex1 Ptpmt1 Inppl1 Zfyve16 Pik3cd XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Map3k1 Casp7 Casp3 Faf1 Arhgdib Map3k7 Sptan1 Map2k4 Pak1 Ripk2 Prkdc Jun Parp1 Mapk8 Fas Fadd Faslg Pak2 Dffa Lmnb2 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Slco1b2 Abcb1a Abcg2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Aars2 Pc Mpc1 Gpt Agxt HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Gch1 Akr1b1 Pts GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Tpi1l2 Rpia Rpe G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Ren1 Ace FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Pdia2 Sdf2l1 Pdia4 Tbxas1 Dnajb11 Gpx1 Hspa5 Alox12 Prxl2b Ugt1a2 Alox5 Slc22a8 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 Ugt2b7 Slc22a6 Cyp2c11 Ugt1a9 Erp29 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Ca1 Slc22a2 Slc22a6 Slc4a4 Slc9a1 Slc1a1 Slc3a1 Aqp1 Slc38a4 Slc3a2 Slc7a6 Slc7a5 Slc7a8 Slc7a9 Slc6a20a IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Elk1 Mapk3 Grb2 Jun Mapk8 Ptpn6 Epo Hras Stat5a Shc1 Epor Sos1 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Ugt2b7 Cyp2d4 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Pgm1 Rpia Rpe Prps1 Pgls Pfkl G6pdx Aldob Tkt Fbp1 HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Ggt6 Gsto2 Gclm Gpx1 Casp7 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Abat Gad1 Dpyd Aldh2 Aoc3 Aldh6a1 Dpys PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Chrm3 Prkca Cacnb1 Cacna1a Rab3a Slc2a2 Rapgef4 Gnaq Camkk1 Gnb1 Vamp2 Itpr3 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Htr6 Creb1 Prkacb Ppp1ca Gnb1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Grin2a Cyp2d4 Cyp3a9 Grin1 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Ahcy Mettl6 Mat2a Scly Cth Slc39a8 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Adcy2 Ptgdr Prkacb Gnb1 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gbe1 Ganab Gys1 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Got1 Pah Tat Yars1 Fah Farsa Hpd Farsb FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Akt1 Rock1 Gnb1 Itpr1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Uap1 Gfpt1 Pgm3 Renbp Npl Nans Cmas Chit1 Nanp Hexa Gnpnat1 ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Abcd2 Abcd1 Pex14 Crat Pex13 Crot Pex11g Slc25a20 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Akr1d1 Cyp17a1 Ugt2b34l1 Sts Srd5a1 Hsd17b1 Cyp19a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Asl Abat Ddo Dars1 Gad1 Asrgl1 Adsl Nars1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Rela Mapk3 Prkca Mapk1 Hras Itpr1 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Aoc1 Dct Got1 Haao Mif Tyr Fah Cat Cyp2e1 Acss1 Aldh3a1 Aldh2 Ddc Comt GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Gh1 Mapk3 Prkca Grb2 Mapk1 Ptpn6 Ghr Hras Stat5a Shc1 Stat5b Slc2a4 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Aars2 Pc Mpc1 Gpt Agxt MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Abat Acss1 Acat1 Acaca Dld Acss3 Mlycd Bckdha Aldh6a1 Pccb Dbt Acadm CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Ugdh Pgm1 Galk1 Galt PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Pik3cg Prkca Akt1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Nmnat1 Nampt Npr1 Ppargc1a Sirt1 Clock Rora Nmnat2 Nqo1 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Hmox1 Ppox Flvcr2 Gusb Ugt2b34l1 Hmbs Ftmt Cox15 Fech Cpox EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Htr7 Creb1 Prkacb Ppp1ca Gnb1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Pdia2 Sdf2l1 Pdia4 Dnajb11 Hspa5 Ugt1a2 Slc22a8 Slc22a6 Cyp2c11 Ptgs2 Ugt2b7 Ugt1a9 Erp29 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Pgam2 Aldoart2 Tpi1l2 Pfkp Slc2a1 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Cyp2d4 Cyp1a2 Slc6a2 Slc6a4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Slc9a1 Prkacb Prkar1b Prkar2a Prkar2b Cacna1g Atp1b4 Atp1a2 Uqcr11 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Cyp1a2 Cyp2d4 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cacna1a KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Aox1 Cyp2a3 Chrnb2 Fmo3 Ugt1a9 Ugt1a5 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Shmt1 Tmlhe Setd7 Bbox1 Aldh9a1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Plpp2 Agpat1 Gpam Gpd1 Aldh3a1 Akr1b1 Gpd2 Lipc Lpl ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Aox1 Rac1 Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Adk Aprt Gucy1b1 Slc29a2 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Abcc4 Atad1 Abcc5 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada Slc28a3 Slc29a1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Ak2 Nme2 Nme1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Aox1 Rac1 Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Adk Aprt Gucy1b1 Slc29a2 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Abcc4 Atad1 Abcc5 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada Slc28a3 Slc29a1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Got1 Gclm Mpst Cth Ctns Cdo1 Cars1 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Elk1 Map3k1 Mapk3 Grb2 Egf Stat6 Rasa1 Csnk2a1 Hras Egfr Stat3 Stat2 Map2k4 Prkca Jun Mapk8 Shc1 Sos1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Slc46a1 Mthfd1 Mthfd2 Mthfs Ftcd Mthfr FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Pmm1 Sord Fbp1 Khk BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Aox1 Alpl NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Ugdh Pgm1 Galt Galk2 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Ren1 Ace PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Ggt6 Gsto2 Gclm Gpx1 Casp7 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Tymp Cda DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Acp1 Tyr ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Pdia2 Sdf2l1 Pdia4 Dnajb11 Hspa5 Ugt1a2 Ugt2b7 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Ugt2b35 Cacna1a Ugt1a9 Erp29 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Acadl Acat1 Hadh Acss3 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Agpat1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Chst11 Suox Papss2 Sult1a1 Bpnt1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Ren1 Ace CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Cyp2c11 Ptgs2 Cyp2d4 Ugt1a9 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Ak2 Nme2 Nme1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Slc5a1 Atp1b1 Atp1a2 Atp1b3 Atp1b2 Atp1a1 Slc2a2 Atp1a4 Atp1a3 Fxyd2 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Aox1 Maob Cyp2d4 Cyp3a9 Slc6a4 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Gpt Slc1a4 Slc2a2 Slc38a4 Slc2a4 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Rrm2b Slc28a3 Slc29a1 Ctps1 Dck Nme1 Dctd WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Aldob Pgam2 Slc16a1 Pklr Pgls Hk2 Slc1a5 Pgk1 Idh1 Gls2 Rpia Idh3a Pfkl Dlst G6pdx Pdhb Taldo1 Sdhc Sdhb Tkt Sdha Slc2a2 Idh3b Cs Dhtkd1 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Uap1 Gfpt1 Pgm3 Renbp Npl Nans Cmas Chit1 Nanp Hexa Gnpnat1 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Aldoart2 Hk2 Slc2a1 Pgk1 Pfkp Idh1 Gls2 Rpia Pdha2 Idh3a Slc16a4 G6pdx Slc1a2 Pdhb Taldo1 Sdhb Sdha Idh3b Cs Dhtkd1 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Uap1 Gfpt1 Pgm3 Renbp Npl Nans Cmas Chit1 Nanp Hexa Gnpnat1 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Msmo1 Hsd17b7 Dhcr24 Dhcr7 Lbr Ebp Sc5d Cyp51a1 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Mtor Mapk1 Stat3 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Ipmk Impa1 Vac14 Bpnt2 Pik3c3 Becn1 Ptpmt1 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Elk1 Rhoa Ralgds Smad3 Mapk3 Smad4 Bad Foxo4 Bcl2l1 Chuk Rac1 Akt1 Hras Ralbp1 Cycs Vav3 Rala Casp9 Pld1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Cyp11a1 Agtr1 Gnaq Cyp21a1 Gnb1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Pgm1 Rpia Rpe Pgls Pfkl Prps1l1 G6pdx Taldo1 Tkt Fbp1 Rbks CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Th Ddc ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Abcb1a Abcg2 Egfr NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Got1 Gclm Mpst Cth Ctns Cdo1 Cars1 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Lpar5 Akt1 Rock1 Gnb1 Itpr1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Aldh1a1 Cyp2c11 Aldh3a1 Cyp2a3 Cyp3a73 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Pik3cg Irs2 Grb2 Map2k2 Pdpk1 Akt1 Hras Insr Mapk1 Mapk8 Shc1 Slc2a4 Sos1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Ip6k1 Ipmk Impa1 Ppip5k1 Bpnt2 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Abcd2 Abcd1 Pex14 Crat Pex13 Crot Pex11g Slc25a20 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Impa1 Pik3r4 Vac14 Pik3c3 Plcd4 Becn1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Ggt6 Gsto2 Gclm Gpx1 Casp7 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Adcy2 Prkacb Drd1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Ephx1 Cyp3a73 Cyp3a9 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Bcl2 Cdk1 E2f1 Gadd45b Bax Cdkn1a Pcna Ccne1 Ccnd1 Cdk4 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Ugdh Gusb Hk2 Pgm2l1 Pygl OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C3 C5 C6 C7 C4 Cfb C1qa C1r Masp2 C1qc C2 Mbl2 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psmb6 Psmb1 Psmc1 Psmc4 Psma2 Psmb3 Psma1 Ubc Psmd4 Psmb2 Uba1 Ubd Psma4 Psmc5 Psma3 Psma5 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Plpp2 Agpat1 Gpam Gpd1 Aldh3a1 Akr1b1 Gpd2 Lipc Lpl GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Elk1 Map3k1 Erbb4 Grb2 Egr1 Hras Gna11 Mmp14 Lrrc7 Src Itpr1 Mmp2 Fshb Lhb Gnrhr Hbegf Camk2a Prkca Adcy5 Cdc42 Jun Mapk1 Mapk8 Pld1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Cyp2c11 Xdh Cyp2a3 Cyp1a2 Nat1 Cyp2e1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Ugt2b7 Cyp2d4 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cacna1a HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Aldob Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Fcsk Pmm1 Fpgt Sord Fbp1 Gfus Khk BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Aldoart2 Pfkp Hk2 Slc2a1 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Elk1 Map3k1 Mapk3 Lyn Grb2 Orai1 Blnk Rac1 Hras Prkca Ppp3ca Jun Mapk8 Ppp3cb Shc1 Btk Nfatc3 Nfatc2 Sos1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Akt1 Rock1 Gnb1 Lpar1 Itpr1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Bdh1 Acat1 Hmgcl Oxct1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Asl Abat Ddo Dars1 Gad1 Asrgl1 Adsl Nars1 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Cyp3a73 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pcyt2 Pisd Pcyt1a HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Impa1 Plcd1 Pik3r4 Itpka Miox Vac14 Becn1 Itpk1 Ptpmt1 Sacm1l Ambra1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Casp3 Hmgb2 Endog Dffa Casp7 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Prkar1b Prkar2a Prkar2b Prkacb Prkaca Gnb1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl23 Rplp1 Rpl13a Rpl35a Fau Kars1 Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Pgm1 Aldoart2 Pfkp Rpia Rpe Prps1 G6pdx Taldo1 Fbp1 Rbks TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gusb Ugt8 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C3 C5 C6 C7 C4 C1qa C1r C1qc C2 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Pgam2 Tpi1l2 Aldob Slc2a2 Bpgm G6pc1 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Pfkfb2 Sord Fbp1 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Cacnb1 Cacna1a Slc2a2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gusb Ugt8 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Aox1 Pnp Nampt Bst1 Nnmt Nnt Nmrk1 Nmnat2 Qprt Nadsyn1 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Hmox1 Ppox Flvcr2 Gusb Ugt2b34l1 Hmbs Ftmt Cox15 Fech Cpox PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Hmox1 Ppox Flvcr2 Gusb Ugt2b34l1 Hmbs Ftmt Cox15 Fech Cpox ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Pfkfb2 Sord ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Pdia2 Sdf2l1 Pdia4 Ptgs2 Dnajb11 Abcb1a Abcc3 Hspa5 Cyp3a73 Erp29 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Abcb1a Slc22a1 Stat5a Sos1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Uap1 Gfpt1 Pgm3 Renbp Npl Nans Cmas Chit1 Nanp Hexa Gnpnat1 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Haao Cat Aanat Tph1 Asmt Kmo Wars2 Wars1 Tdo2 Cyp1a1 Aldh2 Acmsd Ido1 Aadat Ddc LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Rela Ikbkg Chuk Acaca Pfkp Acly Slc25a1 Myd88 Me1 Sdhc Cd14 Sdhb Tirap Sdha Tlr4 Cs Ikbkb HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Adcy2 Fshr Prkacb Avpr2 Gnb1 COAGULATION%SMPDB%SMP0000586 Coagulation Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Acss1 Aldh2 Cat Cyp2e1 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Ugdh Gusb Hk2 Pgm2l1 Pygl GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Plpp2 Agpat1 Gpam Gpd1 Aldh3a1 Akr1b1 Gpd2 Lipc Lpl PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rpl23 Gars1 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Pgm1 Akr1b1 Galt Glb1 Lct G6pc1 B4galt1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Msmo1 Hsd17b7 Dhcr24 Dhcr7 Lbr Ebp Sc5d Cyp51a1 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Got1 Pah Tat Yars1 Fah Farsa Hpd Farsb VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Slco1b2 Abcb1a Abcg2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Gch1 Akr1b1 Pts HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Nmnat1 Nampt Tp53 Sirt1 Nmnat2 Nqo1 Aifm2 Cd38 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Pc Suclg1 Mpc1 Aco2 Dlat Got2 Dld Slc1a5 Slc1a4 Slc16a1 Gls2 Idh2 Acly Idh3a Dlst Pdhb Me1 Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Tpi1l2 Rpia Rpe KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Slc12a1 Ren1 Atp1b1 Atp1a2 Atp1b3 Atp1b2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc12a6 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Slc46a1 Mthfd1 Mthfd2 Mthfs Ftcd Mthfr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl23 Rplp1 Rpl13a Rpl35a Fau Eprs1 Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Th Ddc SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Ugdh Gusb Hk2 Pgm2l1 Pygl ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Cxcr4 Gnai1 Pik3c2g Ptk2 Mapk3 Bcar1 Ptk2b Mapk1 Hras Gnaq Gnb1 Pxn ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Ugdh Gusb Hk2 Pgm2l1 Pygl SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Ren1 Ace Agtr1 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Aox1 Cyp3a9 Cyp2d4 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Maob Cacna1a TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Aldoc Tpi1l2 Aldob Fbp2 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Cyp1a2 Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Aars2 Pc Mpc1 Gpt Agxt TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Map3k1 Mapk14 Atf1 Casp2 Ikbkg Tank Tnf Chuk Map2k6 Map4k2 Map2k3 Tradd Cradd Traf2 Map2k4 Jun Mapk8 Ikbkb TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Abcd2 Aldh3a2 Abcd1 Phyh LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Prkca Akt1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Acadl Hadh Slc25a20 Hadha Hadhb Cpt1a INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Ipmk Impa1 Itpka Ppip5k1 Inpp4a 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Pc Pgm1 Mpc1 Aldob Bpgm Pank3 Pgam2 Slc25a11 Tpi1l2 Slc2a2 Fbp1 Pck1 G6pc1 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Aox1 Atp1a2 Fmo3 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cyp2a3 Cacna1a Ugt1a9 Ugt1a5 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Hmox1 Ppox Flvcr2 Gusb Ugt2b34l1 Hmbs Ftmt Cox15 Fech Cpox GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Carnmt1 Aoc1 Uroc1 Hars1 Aldh3a1 Hdc Cndp2 Aldh2 Hnmt Ftcd Hal PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Mdh2 Slc25a11 Got2 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Itpa Tymp Cda Dpys Ak3 Nme6 Upp2 Dpyd Uckl1 Rrm2b Cant1 Ctps1 Dctd SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Bhmt Mat2a Gnmt Dmgdh Shmt1 Mtr Shmt2 Chdh Sardh Aldh7a1 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C3 C5 C6 C7 C4 Masp2 C2 Mbl2 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Tymp Cda L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rars1 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Abat Gad1 Dpyd Aldh2 Aoc3 Aldh6a1 Dpys TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Cyp3a73 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Pc Mpc1 Slc25a11 Acly Me1 Pdhb CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway Cyp2c11 Abcb1a Cyp1a2 Cyp3a73 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Cacnb1 Cacna1a Slc2a2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Adra1a Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Mecr Ppt1 Hadha Hadhb THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Itpa Tymp Cda Dpys Ak3 Nme6 Upp2 Dpyd Uckl1 Rrm2b Cant1 Ctps1 Dctd FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Inpp5d Grb2 Map2k2 Rac1 Lat Hras Prkca Sos1 Mapk14 Gab2 Lyn Tnf Map2k6 Akt1 Map2k3 Map2k4 Mapk1 Mapk8 Fcer1a Il5 Pdk1 Vav3 Btk Ms4a2 Csf2 Lcp2 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Rpia Rpe Taldo1 Aldob Rbks Fbp2 H6pd Prpsap1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Idh1 Gls2 Idh2 Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Pgm1 Aldoart2 Pfkp Rpia Rpe Pgls G6pdx Taldo1 Fbp1 Rbks SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Mapk3 Prkca Ikbkg Creb1 Mapk1 Ikbkb Nos3 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Btd Hlcs LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Asl Abat Ddo Dars1 Gad1 Asrgl1 Adsl Nars1 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Ggt6 Ado Gad1 Cdo1 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Aox1 Rac1 Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Adk Aprt Gucy1b1 Slc29a2 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Abcc4 Atad1 Abcc5 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada Slc28a3 Slc29a1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Rpia Prps1 Pfkl G6pdx Taldo1 Tkt Fbp1 Rbks QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Hoxb9 Btg1 Prmt1 Ngf Fgf1 Tp53 Ccnd1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Cacnb1 Cacna1a Slc2a2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Gucy1a2 Gucy1b1 Gucy1a1 Trpc7 Trpc4 Kcnq4 Trpc3 Prkg2 Kcnq2 Nos3 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp2c11 Cyp2d4 Cyp1a2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Pcyt2 Abcc3 Slc22a2 Pgk1 Slc22a3 Abcc4 Chpt1 Abcb1a Slc22a1 Sult1a1 Abcg2 Dck Nme1 Pcyt1a VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Abcb1a Cyp2d4 Slc6a2 Slc6a4 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Ugdh Pgm1 Galk1 Galt ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c11 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Pdia2 Sdf2l1 Pdia4 Ptgs2 Dnajb11 Abcb1a Abcc3 Hspa5 Cyp3a73 Erp29 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gusb Ugt8 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification Gsto1 Pnp Slc2a1 Slc2a4 As3mt TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Got1 Pah Tat Yars1 Fah Farsa Hpd Farsb HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Hrh1 Gnaq Gnb1 Itpr1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Ip6k1 Impa1 Itpka Ppip5k1 Itpk1 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl23 Rplp1 Rpl13a Rpl35a Fau Sars1 Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Lpar2 Akt1 Rock1 Gnb1 Itpr1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway Nr1h4 Fgf19 Fgfr1 Fgfr2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Tpi1l2 Pfkp Slc2a13 Pgk2 G6pc3 Aldob Bpgm PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Snta1 Gcg Cacnb1 Cacna1a Slc2a2 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Aldob Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Fcsk Pmm1 Fpgt Sord Fbp1 Gfus Khk BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Abcd2 Abcd1 Pex14 Crat Pex13 Crot Pex11g Slc25a20 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Adcy2 Ptgir Myl3 Mylk Prkacb Gnb1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Map3k1 Mapk14 Rela Ikbkg Chuk Map3k7 Map2k4 Myd88 Cd14 Mapk8 Tlr7 Tirap Tab2 Tlr4 Tlr6 Tlr5 Tlr3 Ikbkb Tlr2 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Pdia2 Sdf2l1 Pdia4 Dnajb11 Abcb1a Hspa5 Abcg2 Cyp3a73 Ugt1a9 Erp29 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Rpia Rpe Taldo1 Aldob Rbks Fbp2 H6pd Prpsap1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Vnn1 Ppcdc METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Pgm1 Rpia Rpe Pgls Pfkl Prps1l1 G6pdx Taldo1 Tkt Fbp1 Rbks TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Ren1 Ace 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Elk1 Creb1 Map2k2 Pdpk1 Prkacb Hras Ikbkb Map3k1 Atf2 Adora2a Arhgef7 Bad Map3k4 Nfkb2 Prkcz Rap1a Chuk Map2k6 Rapgef3 Akt1 Mapk11 Gnb1 Pak1 Mapk1 Jun Mapk8 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Prkca Gnaq Itpr1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Slc46a1 Mthfd1 Mthfd2 Mthfs Ftcd Mthfr SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Abat Acss1 Acat1 Acaca Dld Acss3 Mlycd Bckdha Aldh6a1 Pccb Dbt Acadm TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Mecr Ppt1 Hadha Hadhb ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Tars1 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Pgam2 Slc16a1 Pklr Gls Hk2 Pgk1 Idh1 Rpia Idh3a Pfkl Dlst G6pdx Pdhb Taldo1 Sdhc Sdhb Tkt Sdha Idh3b Cs Dhtkd1 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Gch1 Akr1b1 Pts NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Ugdh Pgm1 Galk1 Galt PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rpl19 Rpl7 Rpl30 Rps15 Rpl10 Rpl9 Rps3a Rpl38l1 Rps25 Rps26 Rps20 Rps27 Rps24 Rps8 Rpl27a Rps6 Rpl24 Aars1 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Abcb1a Abcc3 Cdkn1a Tp53 Ralbp1 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Adra1a Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Ren1 Ace BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Ipmk Prex1 Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Ugdh Gusb Hk2 Pgm2l1 Pygl AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Carnmt1 Aoc1 Uroc1 Hars1 Aldh3a1 Hdc Cndp2 Aldh2 Hnmt Ftcd Hal CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Cyp3a73 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Hadh Slc25a20 Hadha Hadhb Acadm ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Chst11 Suox Papss2 Sult1a1 Bpnt1 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Pdia2 Akr1d1 Sdf2l1 Pdia4 Hsd11b1 Dnajb11 Hspa5 Srd5a1 Erp29 Cyp19a1 Cyp11b3 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Egln3 Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Slc25a10 Idh1 Idh2 Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 Egln2 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Vegfa NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Pdia2 Ugt2b35 Sdf2l1 Pdia4 Dnajb11 Hspa5 Ugt2b7 Ugt1a2 Ugt1a9 Erp29 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Rpia Rpe Taldo1 Aldob Rbks Fbp2 H6pd Prpsap1 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cyp1a2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pcyt2 Ptdss1 Pisd METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Yars1 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Tpi1l2 Pfkp Slc2a13 Pgk2 G6pc3 Aldob Bpgm LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Itpka Miox Pik3c3 Vac14 Becn1 Ptpmt1 Itpk1 Fig4 Ippk Ambra1 Inpp4a Pikfyve Ipmk Impa1 Pik3r4 Plcd3 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2d5 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Acadsb Cyp2c11 Cyp2a3 Ugt1a2 Ehhadh Hadha Hadhb Ivd PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl23 Rplp1 Dars1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Slc5a1 Atp1b1 Atp1a2 Atp1b3 Atp1b2 Atp1a1 Slc2a2 Atp1a4 Lct Atp1a3 Fxyd2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Ren1 Ace METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Snta1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Aldh1a1 Cyp2c11 Cyp2d4 Cyp3a73 Ugt1a9 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 Egfr RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Map3k1 Limk1 Pdgfra Cdkn1a Rac1 Pcna Ralbp1 Ccnd1 Pak1 Mylk Cap1 Ccnd3 Vav3 Wasf1 Ppp1r12b Cdk5 Pld1 Myl2 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Pgam2 Pklr Hk2 Slc2a2 Bpgm Pgk1 G6pc1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gusb Ugt8 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Map3k1 Rela Tnfrsf1b Il1a Tnfrsf1a Il1r1 Ubc Camkk2 Ikbkg Map3k14 Tnf Chuk Tradd Map3k7 Myd88 Fadd Tlr4 Camkk1 Ikbkb METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Cyp3a9 Cyp2d4 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cacna1a BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect Pc Suclg1 Mpc1 Aco2 Aco1 Dld Aldob Pdhx Pgam2 Slc16a1 Pgls Ogdh Slc1a5 Pgk1 Idh1 Rpia Idh3a Pfkl Dlst G6pdx Pdhb Sdhc Sdhb Tkt Slc2a2 Idh3b Cs CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Ggt6 Gsto2 Gclm Gpx1 Casp7 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Hmox1 Ppox Flvcr2 Gusb Ugt2b34l1 Hmbs Ftmt Cox15 Fech Cpox ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Akr1d1 Cyp17a1 Ugt2b34l1 Sts Srd5a1 Hsd17b1 Cyp19a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Ahcy Bhmt Mat2a Mtr Chdh Aldh7a1 BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Btd Hlcs FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Ren1 Ace ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Cars1 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Aars2 Pc Mpc1 Gpt Agxt CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Slco1b2 Abcb1a Abcg2 Ugt2b7 Cyp3a73 Impdh2 Ugt1a9 Impdh1 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Pdia2 Sdf2l1 Pdia4 Dnajb11 Hspa5 Dhrs4 Cyp3a9 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Aldh1a1 Rdh16 Rpe65 Cyp26a1 Dgat1 Retsat Cyp2a3 Dhrs9 Cyp3a73 Erp29 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cyp2d4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway Cyp2c11 Abcb1a Cyp1a2 Cyp3a73 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Cybb Nox4 Nox3 Duox2 Slc5a5 Duox1 Tpo Tg Cyba HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Tpi1l2 Akr1b1 Pfkl Pfkfb1 Fcsk Mpi Fpgt Aldob Sord Fbp1 Gfus Khk INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Elk1 Creb1 Map2k2 Pdpk1 Prkacb Hras Adora2b Ikbkb Map3k1 Atf2 Arhgef7 Bad Map3k4 Nfkb2 Adcy2 Prkcz Rap1a Chuk Map2k6 Rapgef3 Akt1 Mapk11 Gnb1 Pak1 Mapk1 Jun Mapk8 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Pgam2 Pklr Hk2 Slc2a2 Bpgm Pgk1 G6pc1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Sst Cacnb1 Cacna1a Slc2a2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Slc7a5 Mtor Pik3cg Tsc2 Irs2 Tsc1 Insr Akt1 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Gch1 Akr1b1 Pts SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Bdh1 Acat1 Hmgcl Oxct1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling Sirt3 Nlrp3 Tlr4 P4ha3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Ugt2b7 Cyp3a73 Ugt1a9 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Oprk1 Atp1a1 Atp1a4 Atp1a3 Fxyd2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Creb1 Prkacb Ppp1ca Gnb1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Pdia2 Sdf2l1 Pdia4 Cyp1a1 Dnajb11 Hspa5 Cyp3a73 Hsd17b1 Erp29 Comt MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Elk1 Grb2 Hras Egfr Prkca Cacna1c Map3k2 Sos1 Map3k1 Mapk14 Cacnb1 Egr1 Map2k3 Gna11 Mmp14 Prkaca Lrrc7 Src Itpr1 Mmp2 Fshb Lhb Gnrhr Hbegf Camk2a Cacna1d Mapk1 Jun Mapk8 Pld1 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Plcd1 Itpka Miox Pik3c3 Vac14 Becn1 Ptpmt1 Itpk1 Ippk Sacm1l Ambra1 Inpp4a Bpnt1 Ipmk Inpp5j Impa1 Pik3r4 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Elk1 Map3k1 Mapk14 Rela Ikbkg Chuk Map2k6 Map2k3 Map3k7 Map2k4 Myd88 Jun Cd14 Mapk8 Tlr7 Tirap Tab2 Tlr4 Eif2ak2 Ppara Tlr3 Ikbkb Tlr2 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 Pgs1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Elk1 Cd3d Rela Mapk3 Pik3cg Lck Ubc Grb2 Rasgrp1 Rac1 Lat Hras Prkca Sos1 Map3k1 Map2k4 Ppp3ca Jun Mapk8 Ppp3cb Shc1 Ptpn7 Nfatc3 Cd3g Nfatc2 Cd247 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Aox1 Adk Slc29a2 Rac1 Gmps Abcc4 Abcc5 Ppat Xdh Hprt1 Slc28a3 Slc29a1 Impdh1 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacnb1 Cacna1c ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway P2ry2 Ptk2b Prkca MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Itpa Tymp Cda Dpys Ak3 Nme6 Upp2 Dpyd Uckl1 Rrm2b Cant1 Ctps1 Dctd NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Grin2a Xdh Aldh2 Prkca Ppp3ca Prkacb Grin1 Nos1 Itpr1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Pc Suclg1 Mpc1 Aco1 Dlat Dld Pgam2 Gls Aldoart2 Pgls Slc2a1 Pgk1 Pfkp Idh1 Rpia Idh3a Slc16a4 Dlst G6pdx Pdhb Taldo1 Sdhc Sdhb Sdha Cs Dhtkd1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Aox1 Alpl PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Inpp5d Erbb2 Pik3c2a Pten Pik3c3 Vac14 Egfr Becn1 Fig4 Ambra1 Pik3cd Pikfyve Pip4k2a Pik3r4 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Cyp2d4 Cyp3a73 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cyp2c11 Cacna1a APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Got1 Gclm Mpst Cth Ctns Cdo1 Cars1 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Nr1h4 Abcc4 Slco1a4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Abcd2 Abcd1 Pex14 Aldh2 Crat Pex13 Slc25a20 Phyh ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Cant1 Galt Nme2 Slc2a1 Lalba G6pc1 B4galt1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Pdia2 Sdf2l1 Cyp2c11 Pdia4 Dnajb11 Hspa5 Ugt1a9 Erp29 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Pgam2 Pklr Tpi1l2 Hk2 G6pc1 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Pomc Prkacb Gnb1 Mc2r GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gusb Ugt8 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Aldh1a1 Cyp2c11 Aldh3a1 Cyp2a3 Cyp3a73 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin2a Prkca Ppp3ca Prkacb Grin1 Nos1 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Arnt Ahr EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Elk1 Map3k1 Erbb4 Mapk3 Grb2 Egf Rasa1 Csnk2a1 Hras Stat3 Prkca Jun Mapk8 Shc1 Stat5a LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Lpar6 Akt1 Rock1 Gnb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Aldob Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Fcsk Pmm1 Fpgt Sord Fbp1 Gfus Khk GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gusb Ugt8 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Pgam2 Pklr Tpi1l2 Hk2 G6pc1 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Ggt6 Gsto2 Gclm Gpx1 Casp7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp2d4 Cyp1a2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a9 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Aldoc Tpi1l2 Aldob Fbp2 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Hars1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Pgm1 Rpia Rpe Pgls Pfkl Prps1l1 G6pdx Taldo1 Tkt Fbp1 Rbks DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Cyp2d4 Slc6a2 Slc6a4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Lhb Lhcgr Adcy2 Creb1 Prkacb Ppp1ca Gnb1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Slc5a1 Atp1b1 Atp1a2 Atp1b3 Atp1b2 Atp1a1 Slc2a2 Atp1a4 Lct Atp1a3 Fxyd2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Plpp2 Agpat1 Gpam Gpd1 Aldh3a1 Akr1b1 Gpd2 Lipc Lpl ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Tpi1l2 Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Rpia Prps1 Pfkl G6pdx Taldo1 Tkt Fbp1 Rbks SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Agpat1 Gpam Gpd1 Dgat1 Lpin1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Abat Gad1 Dpyd Aldh2 Aoc3 Aldh6a1 Dpys GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugdh Gusb Hk2 Pgm2l1 Pygl 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Aldh8a1 Acmsd Dlst Dld Dhtkd1 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Rpl23 Rplp1 Rpl13a Rpl35a Fau Wars1 Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Ip6k1 Ipmk Impa1 Itpka Ppip5k1 Itpk1 Ippk Inpp4a ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Abat Acss1 Acat1 Acaca Dld Acss3 Mlycd Bckdha Aldh6a1 Pccb Dbt Acadm AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Akr1d1 Cyp17a1 Ugt2b34l1 Sts Srd5a1 Hsd17b1 Cyp19a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Aqp3 Aqp2 Trpv5 Atp1b1 Atp1b3 Atp1b2 Slc12a3 Ren1 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Lck Gab2 Lyn Inpp5d Grb2 Tnf Map2k2 Blnk Rac1 Akt1 Lat Hras Prkca Mapk1 Mapk8 Fcer1a Ms4a2 Csf2 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Mapk3 Prkca Ikbkg Sucnr1 Creb1 Chuk Mapk1 Mapk11 Ikbkb Nos3 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Sult1a1 Fmo1 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Casp3 Arhgdib Casp1 Jun Parp1 Prf1 Arhgap32 Cycs Casp9 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Aldoc Tpi1l2 Aldob Fbp2 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Ggt6 Gsto2 Gclm Gpx1 Casp7 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Nars1 Rplp0 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Tpi1l2 Pfkp Slc2a13 Pgk2 G6pc3 Aldob Bpgm INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Hrh2 Adcy2 Creb1 Prkacb Ppp1ca Gnb1 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Akt1 Lpar3 Gnb1 Itpr1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Idh1 Gls2 Idh2 Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260810%WP227%RATTUS NORVEGICUS Osteoblast signaling Slc34a1 Col1a1 Bglap Pth Pdgfrb Pdgfra Tnfsf11 Fgf23 TNF ALPHA AND MUCUS PRODUCTION IN LUNG EPYTHELIUM%WIKIPATHWAYS_20260810%WP1487%RATTUS NORVEGICUS TNF alpha and mucus production in lung epythelium Mapk1 Tgfa Ikbkg Tnf Nfkbia Egfr Rela Il6 Map2k1 Tnfrsf1a Muc2 Ripk2 Tradd Rps6ka2 Nfkb1 Grb2 Traf2 Chuk Raf1 Sos1 Tlr4 Ikbkb Shc1 PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260810%WP282%RATTUS NORVEGICUS Pentose phosphate pathway Rpia Rpe G6pdx Taldo1 Pgls Kif1b Tkt Pgd ESTROGEN SIGNALING%WIKIPATHWAYS_20260810%WP1279%RATTUS NORVEGICUS Estrogen signaling Elk1 Mnat1 Hdac3 Hdac2 Hdac5 Taf13 Hdac1 Taf12 Akt1 Gtf2f2 Tbp Ccnh Prkaca Fos Gtf2b Gtf2e1 Shc2 Polr2c Src Polr2a Polr2b Taf9 Polr2g Polr2h Polr2f Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2h4 Gtf2h3 Gngt1 Jun Mapk14 Ccnd1 Ercc3 Gper1 Esr1 Crebbp Cdk7 Brca1 Gnb1 Taf7 Taf6 Taf5 Hras Ikbkb Mapk1 Map2k1 Nfkb1 Grb2 Chuk Sos1 Mapk9 Ilk Braf AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260810%WP1287%RATTUS NORVEGICUS Amino acid conjugation of benzoic acid Glyat IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP135%RATTUS NORVEGICUS IL 6 signaling pathway Hdac1 Akt1 Fos Jun Mapk14 Crebbp Hras Socs3 Mapk8 Erbb2 Map3k7 Ppp2r3b Ppp2r3a Mapk3 Hsp90aa1 Map3k4 Ppp2r2c Ppp2r2b Foxo4 Rac1 Mapt Jak2 Foxo3 Jak1 Foxo1 Ppp2cb Ppp2ca Cd40 Plcg1 Gab1 Gab2 Cdk5r1 Eif4e Gsk3b Fgr Hck Ptpa Prkcd Btk Pik3r1 Sgk1 Pik3r2 Il6st Pxn Eif4ebp1 Nlk Ppp2r5c Cebpb Map2k6 Ppp2r5b Ppp2r5a Ncoa1 Rps6kb1 Hspb1 Ptpn11 Shc1 Tmem97 Mapk1 Fyn Il6r Inppl1 Lyn Rb1 Mapkapk2 Casp9 Il6 Bad Casp3 Map2k1 Ptk2b Ppp2r2a Bmx Ptk2 Rps6ka2 Map2k4 Nfkb1 Cdk9 Map2k2 Grb2 Stat5a Stat5b Raf1 Ppp2r1a Sos1 Ppp2r5e Tec Cdk5 Fes Stat3 Hnf1a Daxx CATECHOLAMINE SYNTHESIS%WIKIPATHWAYS_20260810%WP513%RATTUS NORVEGICUS Catecholamine synthesis Ddc Pnmt Th Pah Dbh STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260810%WP316%RATTUS NORVEGICUS Striated muscle contraction Acta1 Acta2 Tnnt2 Actc1 Tnnt1 Tpm4 Tpm3 Tpm2 Neb Tnni3 Tnni2 Tnni1 Tnnc2 Tnnc1 Tmod1 Myh3 Actn3 Mybpc3 Myl2 Actn4 Vim Myl9 Actg1 Tnnt3 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260810%WP1296%RATTUS NORVEGICUS Homologous recombination Nbn Pold2 Rad51 Rad50 Pold1 Brca2 Rad52 Pold4 Pold3 Fsbp ACETATE MEDIATED PROMOTION OF METABOLIC SYNDROME%WIKIPATHWAYS_20260810%WP3650%RATTUS NORVEGICUS Acetate mediated promotion of metabolic syndrome Ins2 Gast NUCLEAR FACTOR ERYTHROID DERIVED 2 LIKE 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP2376%RATTUS NORVEGICUS Nuclear factor erythroid derived 2 like 2 signaling pathway Ran Jun Mapk14 Crebbp Brca1 Hras Mapk8 Map3k7 Mapk3 Gsk3b Prkcd Pik3r1 Pik3r2 Map2k6 Fyn Acta1 Acta2 Actc1 Actg1 Mapk7 Akr7a3 Akr7a2 Prkd3 Eif2ak3 Ube2k Hmox1 Gstk1 Herpud1 Sqstm1 Fth1 Tp53 Prdx1 Prkcq Actb Abcc3 Prkcg Abcc4 Abcc1 Map3k1 Scarb1 Prkci Nras Prkcb Prkce Gstt2 Prkca Gstt1 Vcp Txn Pmf1 Gstm5 Gstm6 Gstm3 Mafg Gstm4 Gstm1 Gstm2 Ubb Rras2 Slc1a4 Prkcz Gclm Mafk Pik3cd Actg2 Fosl1 Bach1 Pik3ca Pik3c2b Pik3c2a Dhcr7 Pik3c2g Ephx1 Akr1a1 Slc35b1 Dnajc5 Aldh3a1 Pik3c3 Ftl1 Xpo1 Mapk1 Gsto1 Gsto2 Slc2a1 Mgst2 Mgst1 Ugdh Cbr1 Nfe2l2 Rras Map2k1 Ldhb Gstp1 Pik3r5 Pik3r6 Pik3r3 Psmc6 Psmc5 Psmc2 Psmc4 Raf1 Psmc3 Map2k7 Aldoa Dnajb4 Nqo1 G6pdx Nqo2 Taldo1 Gss Fmo1 Sod3 Sod2 Sod1 Mapk9 Akr1b10 Usp14 Cdkn1a EBV LMP1 SIGNALING%WIKIPATHWAYS_20260810%WP1278%RATTUS NORVEGICUS EBV LMP1 signaling Mapk1 Traf6 Pdlim7 Ifnb1 Ccl5 Nfkb2 Rela Map3k14 Tradd Nfkb1 Mapk8 Chuk Map3k7 Ikbkb IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP319%RATTUS NORVEGICUS IL 3 signaling pathway Atf2 Spi1 Akt1 Ywhaq Birc5 Matk Crkl Prkaca Tnfrsf1b Bcl2l11 Csf2rb Kcnip3 Ywhab Rac2 Src Rara Rap1a Fcer2 Syk Mmp2 Bcl2l1 Rack1 Mmp9 Dnm1 Rxra Gsk3a Lck Crk Gata2 Vcl Mapk14 Chek1 Mapk7 Ptpn6 Il3ra Selp Il3 Pak1 Rps6kb2 Id1 Cdc42 Rapgef1 Bax Hras Socs3 Mapk8 Mapk3 Prkcb Rac1 Jak2 Prkca Jak1 Foxo1 Ppp2ca Gab1 Gab2 Gsk3b Hck Pik3r1 Pik3cd Pik3r2 Pxn Pik3ca Hspb1 Ptpn11 Shc1 Mapk1 Fyn Slc2a1 Lyn Mapkapk2 Bad Map2k1 Bmx Ptk2 Nfkb1 Grb2 Stat5a Stat5b Raf1 Sos1 Tec Fes Stat3 Mapk9 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260810%WP502%RATTUS NORVEGICUS Nucleotide GPCRs Lpar6 Adora1 P2ry2 P2ry1 Lpar4 Adora2b Adora2a P2ry6 TRANSLATION FACTORS%WIKIPATHWAYS_20260810%WP149%RATTUS NORVEGICUS Translation factors Eif4g3 Eif3b Eif3a Eif1a Eif5b Eif5a Eif2b3 Eif2b2 Eif2b5 Eif4e Eif2b4 Kcnq2 Eif2s2 Eef2k Eif2b1 Eif4h Eif1 Eif1ax Eif6 Eif4a2 Eif4a1 Eif4ebp1 Etf1 Gspt2 Cluh Eif2ak3 Eef1a2 Eef1d Eif3j Pycr3 Eif2s3 Eif2ak1 Eef1g Eif4ebp2 Eif2ak2 Eif3f Eif4g1 VEGFR 3 SIGNALING%WIKIPATHWAYS_20260810%WP1964%RATTUS NORVEGICUS VEGFR 3 signaling Mapk1 Plcg1 Casp9 Bad Akt1 Grb2 Mapk3 Nos3 Itpkc Flt4 Pik3cg Vegfd Vegfc Shc1 SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260810%WP2132%RATTUS NORVEGICUS Serotonin and anxiety Arc Plek Htr2a Crh Htr2c Htr1a Grin2d Prkcb Ppp3ca Fos Nlgn1 Adra1a CFTR ACTIVITY IN THE PLASMA MEMBRANE%WIKIPATHWAYS_20260810%WP1488%RATTUS NORVEGICUS CFTR activity in the plasma membrane Ppp2ca Cftr Plcb3 Plcz1 Plcb2 Plcb1 Prkaca Nherf2 Nherf1 Prkaa2 Snap23 Pdzk1 Ezr Prkcg Rack1 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260810%WP1301%RATTUS NORVEGICUS Mitochondrial gene expression Tfb1m Tfb2m Camk4 Prkar1b Mterf1 Ppargc1a Nrf1 Ppargc1b Gabpa Myef2 Esrra Ppp3ca Gabpb2 Tfam Pprc1 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260810%WP140%RATTUS NORVEGICUS Myometrial relaxation and contraction pathways Atf2 Ywhaq Fos Ywhab Gngt1 Jun Gnb1 Plcg1 Prkcd Nos3 Crh Plcb3 Prkar1b Gabpa Prkd1 Acta1 Ets2 Rgs4 Rgs5 Actc1 Rgs2 Gja1 Rgs3 Rgs1 Crcp Rgs9 Rgs6 Rgs7 Plcg2 Myl4 Mylk2 Prkch Rxfp2 Rxfp1 Myl2 Atf5 Atf3 Maff Pkib Calca Actg1 Grk5 Grk4 Atf6b Gnaq Pkia Grk6 Pkig Oxtr Gucy1a1 Dgkz Gnb2 Gnb4 Gnb3 Rln1 Itpr3 Gng13 Itpr1 Ryr2 Atp2a3 Atp2a2 Oxt Adm Ywhah Ywhag Ywhae Prkcq Adcy3 Actb Adcy4 Nos1 Prkcg Adcy2 Guca2b Adcy7 Guca2a Crhr1 Adcy5 Lpar1 Prkcb Creb3 Prkce Adcy9 Cald1 Prkca Pde4b Prkacb Prkar1a Rgs20 Camk2g Rgs17 Camk2d Igfbp3 Gng3 Rgs19 Camk2b Gng2 Igfbp4 Vkorc1l1 Camk2a Prkcz Rgs14 Gng7 Igfbp1 Rgs16 Pde4d Arrb2 Gng8 Arrb1 Prkar2b Rgs10 Ackr5 Corin Ramp3 Il1b Gsto1 Il6 Nfkb1 WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260810%WP1288%RATTUS NORVEGICUS Wnt signaling pathway and pluripotency Apc Plau Ppm1j Mapk10 Jun Ccnd1 Crebbp Tp53 Prkcq Map3k7 Ppp2r3a Ppp2r2c Prkci Ppp2r2b Prkcb Prkce Prkca Ppp2cb Ppp2ca Gsk3b Ptpa Prkcz Prkcd Fosl1 Nlk Ctnnb1 Pafah1b1 Rhoa Sox2 Ctbp1 Wnt5a Tmem97 Ctbp2 Wnt5b Wnt9b Ppard Axin1 Axin2 Fbxw2 Lef1 Wnt11 Tcf7 Lrp6 Ppp2r2a Nkd2 Lrp5 Wnt6 Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Ppp2r1a Wnt2 Tcf7l1 Wnt4 Cd44 Wnt3 Pou5f1 Fzd3 Ccnd2 Fzd2 Fzd4 Mapk9 Fzd9 Fzd8 Nanog MISMATCH REPAIR%WIKIPATHWAYS_20260810%WP1295%RATTUS NORVEGICUS Mismatch repair Lig1 Pcna Msh2 Rfc1 Pold1 GLYCOGEN METABOLISM%WIKIPATHWAYS_20260810%WP160%RATTUS NORVEGICUS Glycogen metabolism Ppp2cb Ppp2ca Gbe1 Calm3 Gsk3b Phkb Calm2 Gys1 Ptpa Gys2 Phka1 Ugp2 Phka2 Pgm1 Gyg1 Pygb Phkg1 Phkg2 Agl Ppp2r5b Ppp2r5a Gsk3a Ppp2r2a Ppp2r1a Ppp2r3a Ppp2r2c Ppp2r2b TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP457%RATTUS NORVEGICUS TNF alpha NF kB signaling pathway Traf6 Hdac2 Nfkb2 Hdac1 Map3k14 Akt1 Prkaca Tnfrsf1b Ywhab Src Nkiras1 Nr2c2 Nkiras2 Rack1 Tbkbp1 Map3k8 Rps11 Rpl6 Rps13 Pias3 Fbl Rpl30 Ube2i Akt2 Dpf2 Kcnq1 Polr1b Crebbp Rnf216 Polr1a Polr1g Fbxw11 Polr1e Casp8ap2 Txlna Tank Gtf2i Map3k3 Actl6a Map3k2 Smarce1 Tifa Ube2d2 Polr2sl1 Flna Btrc Nfkbiz Glg1 Bag4 Ripk3 G3bp2 Dcaf7 Cops3 Nfkbib Cav1 Ppp2ca Capn3 Kpna6 Ripk1 Mcc Gab1 Kpna3 Kpna2 Dap Cul1 Gsk3b Rel Tab2 Ccar2 Traf4 Mcm7 Pfdn2 Faf1 Csnk2a1 Tnfrsf8 Mark2 Psmd12 Smarcb1 Psmd13 Alpl Rasal2 Akap8 Psmb5 Csnk2b Rps6kb1 Rpl8l1 Hspb1 Cyld Fkbp5 Ptpn11 Mcm5 Fadd Tnip2 Tnip1 Pdcd2 Nsmaf Zfand5 Commd1 Trpc4ap Casp7 Casp3 Psmd6 Fancd2 Psmd3 Ptk2 Elp1 Casp2 Ktn1 Pebp1 Pkn1 Lrpprc Mtif2 Ywhah Ywhag Ywhae Map3k1 Prkcz Ikbkb Ikbkg Tnf Nfkbia Rela Tnfrsf1a Ripk2 Tradd Nfkb1 Traf2 Psmc2 Chuk Psmc3 INTERACTIONS BETWEEN CFTR AND OTHER ION CHANNELS%WIKIPATHWAYS_20260810%WP1485%RATTUS NORVEGICUS Interactions between CFTR and other ion channels Scnn1b Scnn1g Cftr Nherf1 FOCAL ADHESION%WIKIPATHWAYS_20260810%WP188%RATTUS NORVEGICUS Focal adhesion Elk1 Akt1 Rac2 Src Rap1a Crk Jun Vcl Mapk14 Ccnd1 Akt2 Pak1 Cdc42 Rapgef1 Hras Mapk8 Erbb2 Rac1 Cav1 Gsk3b Fgr Hck Pik3r1 Pik3r2 Pxn Map2k6 Pik3cg Vegfd Vegfc Fyn Bad Ptk2 Map2k2 Tnc Comp Mapk4 Ppp1r12a Tnn Akt3 Kdr Tnr Col1a2 Hgf Col5a1 Pgf Lama5 Reln Lama3 Lama4 Thbs1 Tln1 Thbs2 Thbs4 Blk Vasp Shc3 Srms Txk Mylk2 Pdgfc Chad Itga8 Itga6 Itga9 Vtn Itga3 Pdgfa Pdgfb Actg1 Itga10 Cav3 Cav2 Col4a1 Tesk2 Tnk2 Col4a2 Capn1 Ptk6 Col4a6 Igf1 Mylk Mapk7 Ibsp Igf1r Pelo Itgax Itgav Itgam Pdpk1 Itgae Itgal Rap1b Diaph1 Vwf Selenop Itgad Actb Itgb8 Itgb6 Itgb1 Itga2b Itgb5 Itgb2 Actn1 Itgb3 Met Col11a1 Col11a2 Dock1 Bcar1 Lamb3 Spp1 Pak6 Lamb1 Pak3 Pak2 Pak5 Pak4 Vegfb Mapk12 Egf Col6a2 Pten Map2k3 Styk1 Zyx Lamc1 Pik3cd Rock2 Rock1 Pip5k1c Pik3ca Col1a1 Pdgfrb Pdgfra Shc1 Mapk1 Egfr Map2k1 Pik3r5 Grb2 Raf1 Sos1 Ccnd2 Mapk9 Ilk Braf IRINOTECAN PATHWAY%WIKIPATHWAYS_20260810%WP124%RATTUS NORVEGICUS Irinotecan pathway Bche Abcc2 Ces1f Abcc1 Ces1e Ces1d Ces2c Abcg2 ID SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP397%RATTUS NORVEGICUS ID signaling pathway Elk1 Egf Atf3 Myog Ccna2 Ccne1 Myod1 Elk4 Id2 Lck Cd40lg Id4 Id3 Igf1 Hes1 Tcf7l2 Rb1 Psmd4 Igf1r Ngf Bmp6 Rela Pax2 Smad1 Id1 Rbl2 Bmp2 Rbl1 Smad4 Pax8 Nfkb1 Tert Smad5 Srebf1 Myf5 Kdr P53 SIGNAL PATHWAY%WIKIPATHWAYS_20260810%WP656%RATTUS NORVEGICUS p53 signal pathway Igf1 Igfbp3 Casp9 Casp3 Bax Tp53 Ccnb3 Gadd45g Gtse1 Bbc3 Siah1 Perp Pmaip1 Parp1 Mdm2 Ccne1 Cdk1 Fas Bid Rprm GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260810%WP42%RATTUS NORVEGICUS GPCRs class C metabotropic glutamate pheromone Gprc5a Casr Gprc5d Grm1 Gprc5c Grm3 Grm2 Grm5 Grm4 Grm7 Gabbr1 Grm6 Gabbr2 Grm8 Gprc5b IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP355%RATTUS NORVEGICUS IL 1 signaling pathway Nfkbib Traf6 Plcg1 Map3k14 Akt1 Prkcz Il1rap Peli1 Irak4 Irak3 Irak2 Tollip Sirpa Il1a Il1r2 Capns1 Il1r1 Il1b Tab1 Il1rn Ptpn11 Capn1 Mapk1 Nfkbia Rela Map2k1 Sqstm1 Elp1 Nfkb1 Mapk8 Chuk Map3k7 Mapk3 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260810%WP632%RATTUS NORVEGICUS Cholesterol metabolism Soat1 Apoc2 Lpl Fdft1 Lss Hmgcs1 Hmgcr Apoe Mvd Msmo1 Srebf1 Dhcr7 Scarb1 Fdps Idi1 Mvk Rusc1 Apoc1 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260810%WP270%RATTUS NORVEGICUS Tryptophan metabolism Gcdh Aoc1 Dhcr24 Haao Asmt Cyp2d26 Echs1 Cyp2e1 Kynu Cyp1a1 Cat Cyp2a2 Cyp2a1 Ube3a Acmsd Ido1 Hadh Tph1 Aldh1a1 Aldh3a2 Aldh2 Aldh9a1 Inmt Acad10 Cyp2j3 Hsd17b10 Cyp2b15 Wars1 Cyp2j4 Prmt1 Tdo2 Cyp4f1 Cyp2f2 Ddc Aadat Mdm2 Cyp1b1 Ogdh Cyp7b1 Aanat Afmid STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP66%RATTUS NORVEGICUS Steroid biosynthesis Hsd3b6 Hsd17b7 Hsd3b5 Hsd17b3 Hsd3b1 Hsd17b4 Hsd17b1 Hsd17b2 F13b Cyp17a1 TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260810%WP1280%RATTUS NORVEGICUS Transcriptional activation by Nfe2l2 in response to phytochemicals Mapk8 Nqo1 Cebpb Nfe2l2 Hmox1 Aimp2 Maf Prkca Gclm Ephb2 TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260810%WP1289%RATTUS NORVEGICUS Type II interferon signaling IFNG Ifnb1 Spi1 Prkcd Il1b Cxcl10 Ptpn11 Cxcl9 Ifng Ifngr2 Oas1a Ifngr1 Reg1 Psmb9 Gbp1 Nos2 Hist1h4m Tap1 Ciita Irf4 Cybb Irf1 Irf2 Socs3 Irf8 Isg15 Irf9 Ifit2 Eif2ak2 Jak2 Jak1 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260810%WP1291%RATTUS NORVEGICUS Phase I biotransformations non P450 Pon3 Ces5a Pon1 Pon2 Ces2j Esd Lipa BRAIN DERIVED NEUROTROPHIC FACTOR%WIKIPATHWAYS_20260810%WP2148%RATTUS NORVEGICUS Brain derived neurotrophic factor Mapk1 Raf1 Map2k1 Ngfr Ntrk2 Bdnf Serpine1 Plat Plg STATIN PATHWAY%WIKIPATHWAYS_20260810%WP145%RATTUS NORVEGICUS Statin pathway Abca1 Soat1 Mttp Lpl Cyp7a1 Lcat Hmgcr Scarb1 Apoe Apoc1 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP147%RATTUS NORVEGICUS Kit receptor signaling pathway Stap1 Mitf Grb10 Socs5 Socs4 Akt1 Socs6 Ptpru Matk Cltc Crkl Sh3kbp1 Cblb Vav2 Csf2rb Dok1 Rps6ka1 Kit Tnfrsf10b Src Spred1 Mpdz Spred2 Grb7 Rasa1 Abl1 Grap Plce1 Sh2b2 Crk Ptpn6 Hras Prkcb Jak2 Prkca Plcg1 Fgr Hck Btk Pik3r1 Pik3r2 Pik3cg Ptpn11 Shc1 Mapk1 Fyn Lyn Bad Map2k1 Grb2 Stat5a Stat5b Raf1 Sos1 Tec Fes Stat3 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260810%WP139%RATTUS NORVEGICUS Nuclear receptors in lipid metabolism and toxicity Abca1 Cyp7a1 Cyp2e1 Rara Abcc2 Nr1i3 Nr1i2 Abcb1a Abcd2 Cyp27b1 Abcd3 Cyp2c11 Abcb4 Ppard Cyp4b1 Rarb Cyp2b2 Cyp8b1 Vdr Nr1h3 Ppara Pparg Abcg1 Cyp24a1 Abcg5 Cyp26a1 Abcb11 Abcc3 VEGF RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260810%WP1965%RATTUS NORVEGICUS VEGF receptor signal transduction Mapk1 Pgf Plcg1 Mapkapk2 Casp9 Vegfb Bad Akt1 Pik3r3 Grb2 Sh2d2a Src Hspbp1 Raf1 Pxn Nos3 Prkci Rac1 Vegfc Prkca Shc1 FRUCTOSE METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260810%WP3894%RATTUS NORVEGICUS Fructose metabolism in proximal tubules Akr1b1 Fbp1 Slc2a5 Pfkp Gpi Slc5a9 Aldoa Tpi1 Psme3 Slc5a10 Sord Aldob G6pc1 Hk1 Khk Pfkl Tkfc Naglt1 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP94%RATTUS NORVEGICUS Hepatocyte growth factor receptor signaling Elk1 Itga1 Gab1 Map4k1 Pten Crkl Fos Src Pxn Pik3ca Rap1a Rasa1 Ptpn11 Crk Mapk1 Jun Pak1 Map2k1 Ptk2b Rapgef1 Rap1b Ptk2 Hras Map2k2 Grb2 Mapk8 Raf1 Itgb1 Sos1 Mapk3 Stat3 Met Dock1 Hgf HEXOSES METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260810%WP3916%RATTUS NORVEGICUS Hexoses metabolism in proximal tubules Gpi Slc5a9 Tpi1 Psme3 Slc5a10 Sord Aldob G6pc1 Hk1 Khk Pfkl Tkfc Akr1b1 Fbp1 Slc2a5 Pfkp Pdhx Eno1 Eno3 Eno2 Pc Mpc1 Mpc2 Pdk4 Pgam2 Slc2a2 Pdk3 Pgam1 Pdk2 Pdk1 Pdhb Gapdh Ldha Dld Pklr Aldoc Acly Pdha1 Pgk1 Slc5a1 Pck1 Slc5a2 Got1 Mdh1 Mdh2 Got2 Pdp1 Pdp2 Ldhb Aldoa HYPOTHETICAL NETWORK FOR DRUG ADDICTION%WIKIPATHWAYS_20260810%WP1281%RATTUS NORVEGICUS Hypothetical network for drug addiction Acta1 Mapk1 Grm1 Grin2a Grin2d Nisch Grm5 Camk2b Krit1 Map2k1 Terf2ip Gria2 Gria1 Prkaca Ppa1 Drd1 Grin1 Adcy8 Grin2c Drd4 Grin2b Camk4 Mapk3 Prkce SPINAL CORD INJURY%WIKIPATHWAYS_20260810%WP2433%RATTUS NORVEGICUS Spinal cord injury Lilrb2 Sox9 Tnfsf13b Zfp36 Gap43 Gja1 Arg1 Prpg2 Omg Plxna2 Epha4 Mag Rtn4r Tacr1 Fos Anxa1 Pla2g2a Ccng1 Gadd45a Ntn1 Klk8 Il2 Rtn4 Vim Gfap Il1a Il4 Bcan Tnfsf13 Il1r1 C5 Mmp9 Tgfb1 Col4a1 Gdnf Ccl2 Pla2g5 Mbp Cd47 Cxcl1 Cxcl2 Pla2g6 Ccnd1 Fcgr2a Egr1 Selp Ptpra Ncan Acan Xylt1 Nox4 E2f1 E2f5 Tp53 Nos1 Mapk3 Prkca Rock2 Il1b Ppp3ca Cxcl10 Mapk1 Ifng Rb1 Il6 Nos2 Casp3 Grin1 Btg2 Chst11 Tlr4 Fkbp1a Ptprz1 Slit1 Slit2 Aqp4 Slit3 Ngfr Pdyn Cdk1 Bdnf Rgma Necab3 Vcan Sema6a INSULIN INDUCED PI3K AKT AND MAPK IN HEPATOCYTES%WIKIPATHWAYS_20260810%WP4229%RATTUS NORVEGICUS Insulin induced PI3K Akt and MAPK in hepatocytes Foxo1 Grb10 Akt1 Eif4e Gys1 Gys2 Rps6ka1 Eif4ebp1 Acly Rps6kb1 Pik3c3 Gsk3a Shc1 Mapk1 Bad Rptor Ins1 Irs2 Mtor Grb2 Pfkfb2 Rheb Foxk1 Raf1 Akt1s1 Sos1 Rps6 Mapk3 Tsc2 Tsc1 Mlst8 NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP517%RATTUS NORVEGICUS Notch signaling pathway Maml1 Mfng Numb Hes5 Jag2 Jag1 Hdac1 Kat2a Rfng Numbl Notch1 Notch2 Lfng Notch3 Psen1 Psen2 Ctbp1 Ctbp2 Hes1 Crebbp Dvl1 Dvl2 Dvl3 Aph1a Ncstn Dtx2 Dtx3 Dtx4 Dll3 Dll4 Rbpjl COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260810%WP547%RATTUS NORVEGICUS Complement and coagulation cascades Plau Vwf Cr2 Serping1 Cr1l Kng2l1 C3ar1 Serpinf2 Mbl1 Fgb Masp1 Masp2 Tfpi F13b F2 C8b F3 F7 F8 F9 Plaur Cfb C1qb Cfd C1qa Cd59b Cfh Cfi F2r Klkb1 Kng2 C2 Proc C4 C6 C9 Serpind1 Cd46 F10 C1s C1r F12 Thbd Pros1 Serpinc1 A2m Cpb2 Cd55 C1qc Serpine1 Plat Plg MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP358%RATTUS NORVEGICUS MAPK signaling pathway Elk1 Traf6 Mapk10 Nfkb2 Map3k14 Atf2 Akt1 Crkl Prkaca Fos Gadd45a Rap1a Il1a Il1r2 Il1r1 Tgfb1 Map3k8 Crk Jun Mapk14 Akt2 Pak1 Cdc42 Hras Mapk8 Map3k7 Map3k2 Mapk3 Map3k4 Flna Rac1 Mapt Tab2 Prkcd Nlk Map2k6 Hspb1 Ppp3ca Tmem97 Mapkapk2 Casp3 Map2k4 Daxx Akt3 Ntrk2 Bdnf Cacng8 Cacna1g Cacna1h Cacna1e Cacng7 Cacna1f Cacna1c Cacna1d Cacna1a Cacna1b Cacng1 Fgf2 Cacng4 Fgf1 Map3k6 Cacng5 Fgf4 Map3k5 Fgf3 Cacng3 Fgf6 Fgf5 Fgf8 Fgf7 Cacna1s Pdgfa Fgf9 Map3k20 Rasa1 Lamtor3 Rasgrp3 Rasgrp4 Rasgrp1 Flnc Rasgrp2 Flnb Cdc25b Jund Stmn1 Stk4 Map4k3 Tgfb2 Tgfb3 Nf1 Ppp3cc Ppp3cb Fgfr3 Fgfr4 Fgfr1 Fgfr2 Map4k2 Tp53 Rasgrf2 Cd14 Faslg Fgf16 Fgf17 Prkcg Fgf14 Ppp5c Pla2g4b Map3k1 Fgf18 Pla2g4e Fgf19 Nras Pla2g4d Pla2g4a Fgf12 Fgf13 Prkca Fgf10 Fgf11 Prkacb Nfatc1 Nfatc3 Fgf20 Rps6ka3 Rps6ka4 Pak2 Cacna2d1 Map4k1 Sos2 Cacna2d3 Cacna2d4 Gna12 Egf Dusp16 Rras2 Ppm1b Ptpn7 Ptpn5 Dusp3 Ntf4 Dusp2 Hspa1l Dusp4 Arrb2 Ntf3 Arrb1 Dusp10 Dusp9 Dusp8 Mapk13 Cacnb4 Cacnb1 Cacnb2 Il1b Pdgfrb Taok2 Taok1 Taok3 Elk4 Mapkapk5 Ikbkb Mos Ntrk1 Mapk1 Mef2c Rapgef2 Ikbkg Mapk8ip1 Mapk8ip3 Mknk1 Egfr Ngf Map3k11 Rela Tgfbr1 Rras Map2k1 Tnfrsf1a Nfkb1 Grb2 Traf2 Chuk Raf1 Sos1 Map2k7 Fas Mapk9 Braf SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP2541%RATTUS NORVEGICUS Sulindac metabolic pathway Msra Msrb2 Cyp1a1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260810%WP351%RATTUS NORVEGICUS Regulation of actin cytoskeleton Rassf7 Apc Gna13 Fgd1 Csk Tmsb4x Arhgap35 Wasf2 Gsn Wasf1 Limk1 Pip5k1b Pip5k1a Crk Vcl Pak1 Cdc42 Ins1 Mapk3 Rac1 Pik3r1 Pik3r2 Pxn Pik3cg F2 F2r Ptk2 Ezr Mapk4 Fgf2 Fgf1 Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Pdgfa Fgf9 Actg1 Ins2 Mylk Fgfr3 Fgfr4 Fgfr1 Fgfr2 Cd14 Actb Fgf16 Fgf17 Fgf14 Fgf18 Fgf19 Nras Fgf12 Fgf13 Dock1 Fgf10 Bcar1 Fgf11 Pak6 Fgf20 Pak3 Pak2 Itga1 Pak5 Sos2 Pak4 Gna12 Egf Rras2 Pik3cd Rock1 Pik3ca Pik3c2b Pik3c2a Pik3c2g Pdgfrb Pdgfra Rhoa Pik3c3 Fgf23 Mos Mapk1 Egfr Rras Map2k1 Cfl1 Cfl2 Pip4k2b Pik3r5 Pfn1 Pip4k2a Pik3r3 Arhgef7 Arhgef6 Arhgef1 Myh10 Raf1 Chrm1 Chrm3 Sos1 Nckap1 Chrm2 Chrm5 Chrm4 Slc9a1 Ssh3 Ssh2 Ssh1 Arpc5 Enah Baiap2 Braf Git1 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260810%WP173%RATTUS NORVEGICUS Oxidative stress response Mapk14 Mapk10 Mgst1 Hmox1 Cyp1a1 Cat Nfix Gpx3 Fos Txn2 Nfkb1 Txnrd2 Cyba Junb Xdh Nqo1 Sod3 Sod2 Sod1 Gstt2 BETA OXIDATION OF UNSATURATED FATTY ACIDS%WIKIPATHWAYS_20260810%WP418%RATTUS NORVEGICUS Beta oxidation of unsaturated fatty acids Hadha Hadhb Eci1 Acadm Decr1 RETINOL METABOLISM%WIKIPATHWAYS_20260810%WP1297%RATTUS NORVEGICUS Retinol metabolism Cyp2e1 Rara Dhrs3 Sult2b1 Cd36l1 Rdh12 Aldh1a3 Rxra Rdh10 Adh5 Adh4 Cyp26b1 Adh1 Lpl Bco1 Sult1a1 Npc1l1 Rarb Rpe65 Rxrb Rbp7 Abcg8 Rbp4 Retsat Aldh1a1 Crabp2 Cd36 Rxrg Abcg5 Lrat Cyp26a1 Rlbp1 Scarb1 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260810%WP1277%RATTUS NORVEGICUS Non homologous end joining Xrcc6 Prkdc Xrcc4 Rad50 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260810%WP557%RATTUS NORVEGICUS ACE inhibitor pathway Kng2l1 Ren1 Ace Agtr1b Agtr2 Nos3 Bdkrb2 Agt Kng2 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP294%RATTUS NORVEGICUS p38 Mapk signaling pathway Elk1 Ripk1 Atf2 Map3k5 Map2k6 Hspb1 Mapkapk5 Shc1 Mapk14 Tgfb2 Mknk1 Mapkapk2 Tgfbr1 Cdc42 Tradd Map2k4 Hras Grb2 Traf2 Map3k7 Map3k1 Max Daxx Pla2g4a Map3k9 Mef2d Rac1 Rps6ka5 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260810%WP133%RATTUS NORVEGICUS Fatty acid omega oxidation Adh6 Acad10 Adh1 Cyp2e1 Cyp1a1 Aldh1a1 Aldh2 Cyp4a2 Cyp3a2 Adh5 Adh4 Adh7 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260810%WP146%RATTUS NORVEGICUS Nucleotide metabolism Dhfr Prps2 Polb Impdh1 Nme2 Mthfd2 Hprt1 Polg Adss2 Pold1 Sat1 Srm PROTEASOME DEGRADATION%WIKIPATHWAYS_20260810%WP302%RATTUS NORVEGICUS Proteasome degradation Psma5 Rpn2 Psma2 Rpn1 Psme2 Psme1 Psmd11 Ube2b Psmd12 Uchl3 Psmb8 Psmd13 Psmb6l1 Psmb7 Psmd8 Uchl1 Psmb5 Psmb1 Psmd2 Psmd5 Psmb2 Ube2d3 Ube2d1 Psmd4 Psmb9 Psmd6 Psmd3 Psmc6 Psmc5 Psmc2 Psmc4 Psmc3 METHYLATION%WIKIPATHWAYS_20260810%WP1282%RATTUS NORVEGICUS Methylation Comt Mat2a Mat1a Hnmt Pnmt Inmt MONOAMINE GPCRS%WIKIPATHWAYS_20260810%WP276%RATTUS NORVEGICUS Monoamine GPCRs Adra1a Htr2a Adra2a Htr2c Adra2c Htr1a Adra2b Htr4 Hrh1 Htr6 Htr7 Hrh2 Adrb1 Drd1 Drd3 Drd5 Adra1b Adrb3 Drd4 Adra1d Chrm1 Htr1d Chrm3 Htr1f Htr5b Chrm2 Htr5a Chrm5 Chrm4 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260810%WP1283%RATTUS NORVEGICUS Oxidative phosphorylation Atp5pf Ndufb10 Atp5po Ndufs2 Ndufs5 Ndufs4 Ndufs6 Mt-co3 Ndufs8 Mt-nd5 Adck2 Mt-nd4 Ndufb2 Mt-atp6 Mt-nd6 Atp5mc1 Mt-nd1 Mt-nd3 Mt-nd4l Mt-nd2 Ndufb8 Ndufb7 Atp5mc3 Atp5mf Atp5me Ndufv1 Ndufv3 Atp5f1a Ndufa10l1 Ndufab1 Ndufc1 Coxfa4 Ndufc2 Ndufa5 Gzmb Atp5pb Gzmc Ndufa9 Ndufa8 GLUCOCORTICOID METABOLISM%WIKIPATHWAYS_20260810%WP305%RATTUS NORVEGICUS Glucocorticoid metabolism Hsd11b1 Hsd11b2 Cyp17a1 Cyp21a1 Cyp11a1 Akr1c9 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP1284%RATTUS NORVEGICUS EPO receptor signaling Mapk1 Ptprc Epo Map2k1 Akt1 Ptpru Irs2 Map2k2 Grb2 Stat5a Stat5b Src Raf1 Sos1 Pdk1 Mapk3 Rasa1 Stat3 Pik3cg Jak2 Shc1 ESTROGEN METABOLISM%WIKIPATHWAYS_20260810%WP1302%RATTUS NORVEGICUS Estrogen metabolism Comt Sult1a1 Sult1e1 Arsl Nqo1 Gstm1 Cyp1a1 Cyp1b1 ADIPOGENESIS%WIKIPATHWAYS_20260810%WP155%RATTUS NORVEGICUS Adipogenesis Gadd45a Rara Tgfb1 Rxra Cyp26b1 Gata2 Lpl E2f1 Rxrg Irs2 Socs3 Agt Mef2d Foxo1 Il6st Cebpb Ncoa1 Cfd Rb1 Stat5a Stat5b Ppargc1a Stat3 Hnf1a Serpine1 Ins2 Igf1 Nampt Nrip1 Trib3 Ahr Nr1h3 Lifr Ppara Prlr Pparg Bscl2 Foxc2 Twist1 Ebf1 Cyp26a1 Mif Retn Mbnl1 Frzb Cntfr Gata3 Gata4 Nr3c1 Gh1 Hif1a Gtf3a Ndn Cisd1 Pck2 Egr2 Lif Bmp4 Bmp3 Wwtr1 Bmp1 Lipe Hmga1 Plin2 Adipoq Epas1 Slc2a4 Scd1 Sfrp4 Nr2f1 Ptgis Klf15 Ncor1 Ucp1 Gadd45b Pnpla3 Cebpd Ncoa2 Zmpste24 Asip Osm Lpin3 Celf1 Lpin1 Dlk1 Mixl1 Mef2a Pck1 Mef2b Klf5 Mef2c Lep Wnt5b Id3 Spock1 Gdf10 Tnf Ppard Agpat2 Il6 Rbl2 Bmp2 Rbl1 Dvl1 Srebf1 Fas Necab3 Cdkn1a NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP1294%RATTUS NORVEGICUS Nod like receptor NLR signaling pathway Mapk8 Chuk Ikbkg Map3k7 Cd40 Rela Ephb2 Ikbkb SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260810%WP349%RATTUS NORVEGICUS Synthesis and degradation of ketone bodies Hmgcl Bdh1 Oxct1 Hmgcs2 INSULIN SIGNALING%WIKIPATHWAYS_20260810%WP439%RATTUS NORVEGICUS Insulin signaling Elk1 Rrad Inpp4a Ppp1r3a Vamp2 Mapk10 Rps6ka6 Mink1 Sgk3 Map3k14 Sgk2 Akt1 Myo1c Enpp1 Ptpn1 Stx4 Gys1 Arhgap33 Gys2 Fos Map3k10 Mapk11 Shc2 Gyg1 Rac2 Map3k8 Gsk3a Crk Jun Mapk14 Akt2 Egr1 Rps6kb2 Rapgef1 Rptor Hras Irs2 Mtor Mapk8 Map3k3 Rheb Map3k7 Map3k2 Mapk3 Tsc2 Tsc1 Map3k4 Map3k9 Rac1 Rps6ka5 Foxo3 Foxo1 Gab1 Eif4e Gsk3b Prkcd Pik3r1 Sgk1 Pik3r2 Eif4ebp1 Map2k6 Pik3cg Rps6kb1 Ptpn11 Inppl1 Reg1 Map2k4 Prkaa2 Snap23 Map2k2 Mapk4 Grb10 Map3k6 Shc3 Cblb Map3k5 Prkch Rps6ka1 Sh2b2 Map4k3 Igf1r Trib3 Pdpk1 Map4k2 Prkcq Map3k1 Prkci Prkcb Prkca Pfkl Rps6ka3 Rps6ka4 Lipe Map4k1 Sos2 Mapk12 Slc2a4 Pten Prkcz Pik3cd Pik3c2a Mapk13 Pik3c2g Pik3c3 Ikbkb Shc1 Mapk1 Slc2a1 Map3k11 Cyth3 Map2k1 Grb14 Stxbp1 Stxbp2 Stxbp3 Stxbp4 Rps6ka2 Prkaa1 Kif5b Grb2 Cblc Insr Raf1 Flot2 Flot1 Sos1 Map2k7 Map4k5 Rab4a Xbp1 Kif3a Tbc1d4 Ehd1 Ehd2 Snap25 Arf1 Mapk9 Rhoj Ptprf Cap1 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260810%WP469%RATTUS NORVEGICUS Glutathione metabolism Gstm6 Gstm3 Gstm2 Gpx3 Gclm Ggt5 Anpep Ggt1 Oplah G6pdx Gss Gstt2 Gstt1 APOPTOSIS%WIKIPATHWAYS_20260810%WP1290%RATTUS NORVEGICUS Apoptosis Mapk10 Akt1 Birc5 Tnfrsf1b Bcl2l11 Tnfrsf10b Prf1 Hells Traf1 Bcl2l2 Xiap Bnip3l Irf3 Lta Irf7 Irf5 Irf6 Diablol1 Bak1 Tp73 Jun Tnfrsf25 Igf2 Dffa Igf1r Dffb Tp63 Bax Tp53 Faslg Map3k1 Nfkbib Ripk1 Pik3r1 Ikbkb Fadd Ikbkg Nfkbia Rela Casp9 Bad Casp7 Casp3 Tnfrsf1a Irf4 Tradd Irf1 Casp2 Map2k4 Nfkb1 Irf2 Traf2 Chuk Pmaip1 Fas Bid GLUCOCORTICOID EFFECT ON TARGET GENE EXPRESSION%WIKIPATHWAYS_20260810%WP1963%RATTUS NORVEGICUS Glucocorticoid effect on target gene expression Nfkbia Tsc22d3 Nr3c1 Hspa4 Rras Mt-co2 Fkbp4 Pla2g4a Anxa1 Nfkb1 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260810%WP1312%RATTUS NORVEGICUS S1P receptor signal transduction Mapk1 Akt2 Mapk12 Plcb3 Akt1 Smpd2 Plcb2 Plcb1 Asah1 Sphk2 Sphk1 S1pr1 Gnai1 S1pr3 Gnai3 Pik3c2b Mapk3 Mapk4 Akt3 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260810%WP74%RATTUS NORVEGICUS Integrin mediated cell adhesion Mapk10 Tln1 Akt1 Vasp Shc3 Vav2 Mylk2 Itga8 Itga6 Rac2 Src Itga9 Rap1a Itga3 Itga10 Capns1 Cav3 Cav2 Capn1 Crk Vcl Mapk7 Akt2 Itgax Itgav Pak1 Itgam Pdpk1 Itgae Cdc42 Itgal Rapgef1 Rap1b Hras Selenop Itgad Itgb8 Vav3 Itgb6 Itgb1 Itgb4 Itga2b Itga2 Itgb5 Rho Itgb2 Capn9 Git2 Itgb3 Capn5 Capn7 Capn6 Rac1 Capn2 Dock1 Bcar1 Pak6 Cav1 Pak3 Capn3 Pak2 Itga1 Pak4 Mapk12 Map2k3 Zyx Rock2 Rock1 Pik3r2 Pxn Map2k6 Shc1 Mapk1 Fyn Map2k1 Ptk2 Arhgef7 Map2k2 Grb2 Raf1 Sos1 Mapk4 Akt3 Ilk Braf GPCRS OTHER%WIKIPATHWAYS_20260810%WP409%RATTUS NORVEGICUS GPCRs other Grm1 Grm8 Rxfp1 Adora2a S1pr1 Prokr2 Adgrg1 Cxcr1 Ednra Gnrhr Ntsr1 Fshr Gpr61 Or1n1 Ccr5 Ccr2 Gpr176 Cckbr Alg6 Adgrl2 Adgrl3 Gpr135 Sstr2 Smo Taar3 Rxfp3 Taar2 Taar5 Ghrhr Gpr183 C5ar2 Or3a1e Or2a5 Ptgfr Hrh4 Gpr88 Or2f1 Celsr2 Cnr1 Gpr18 Grpr Uts2r P2ry13 Htr2a Gpr17 Ltb4r2 Lgr6 Or10a2 F2r Htr7 Drd3 Adra1d Drd4 Htr1f Chrm3 Chrm2 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260810%WP1300%RATTUS NORVEGICUS Aflatoxin B1 metabolism Akr7a3 Akr7a2 Gstm1 Ephx1 TOLL LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP1309%RATTUS NORVEGICUS Toll like receptor signaling pathway Traf6 Ifnb1 Mapk10 Ccl5 Nfkb2 Akt1 Fos Tollip Irf3 Map3k8 Irf7 Irf5 Jun Mapk14 Akt2 Cd14 Mapk8 Map3k7 Mapk3 Rac1 Spp1 Cd40 Ripk1 Map2k3 Tab2 Pik3r1 Pik3cd Pik3r2 Pik3ca Mapk13 Map2k6 Il1b Pik3cg Ikbkb Cxcl10 Cxcl9 Mapk1 Fadd Ikbkg Tnf Nfkbia Il12b Rela Il12a Il6 Ticam2 Map2k1 Lbp Cd86 Cd80 Pik3r5 Ly96 Tlr1 Pik3r3 Map2k4 Nfkb1 Ifna4 Ifna1 Tlr8 Tlr7 Chuk Tlr6 Tlr5 Map2k7 Tlr4 Tlr3 Tlr2 Cxcl11 Ifnar1 Ccl4 Ccl3 Akt3 Mapk9 RENIN ANGIOTENSIN SYSTEM%WIKIPATHWAYS_20260810%WP376%RATTUS NORVEGICUS Renin angiotensin system Elk1 Enpep Ctsa Nln Cma1 Mapk10 Lnpep Mas1 Itpr2 Atf2 Prkaca Fos Anpep Jun Itpr3 Pak1 Itpr1 Mapk8 Prkcq Ren1 Ace Mapk3 Agtr2 Map3k1 Agt Rac1 Jak2 Pak6 Pak3 Pak2 Pak5 Pak4 Pik3ca Mapk13 Ikbkb Shc1 Mapk1 Ikbkg Rela Ptk2b Plcb1 Ptk2 Map2k4 Grb2 Raf1 Map2k7 Stat3 Ctsg Cpa3 Mme Mapk9 Agtr1 Ace2 Ptgir SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260810%WP1293%RATTUS NORVEGICUS Selenium metabolism selenoproteins Selenbp1 Msrb1 Eefsec Crem Sp3 Selenof Sars2 Gpx3 Fos Selenoi Txnrd2 Sars1 Selenok Fabp1 Selenoo Gpx6 Selenos Dio1 Selenot Dio2 Dio3 Selenov Selenow Sephs1 Trnau1ap Jun Rpl30 Rela Nfe2l2 Nfkb1 Selenop APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260810%WP487%RATTUS NORVEGICUS Apoptosis modulation by HSP70 Hspa1b Fadd Mapk10 Ripk1 Casp9 Casp7 Casp3 Tnfrsf1a Casp2 Nfkb1 Faslg Map3k1 Fas Cycs Bid Casp6 Aifm1 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260810%WP40%RATTUS NORVEGICUS Inflammatory response pathway Ifng Il4r Lama5 Lamb1 Cxhxorf65 Cd40 Il2ra Il2rb Il2rg Thbs1 Il5 Il5ra Tnfrsf1a Cd86 Cd80 Tnfrsf1b Lamc1 Il2 Vtn Il4 Col1a1 Col1a2 Lck Cd40lg POLYOL PATHWAY%WIKIPATHWAYS_20260810%WP1303%RATTUS NORVEGICUS Polyol pathway Akr1b1 Sord Aldob Khk IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP44%RATTUS NORVEGICUS IL 5 signaling pathway Elk1 Atf2 Akt1 Crkl Rps6ka1 Shc2 Syk Sh2b2 Gsk3a Jun Mapk14 Ptpn6 Il5 Il5ra Rap1gap Itgam Alox5 Pim1 Sox4 Rapgef1 Sdcbp Bax Alox5ap Hras Hcls1 Unc119 Cdkn1b Mapk3 Itgb2 Pla2g4a Prkcb Rac1 Jak2 Foxo3 Jak1 Gsk3b Hck Prkcd Btk Pik3r1 Pik3r2 Ctnnb1 Pik3cg Ptpn11 Shc1 Mapk1 Lyn Nfkbia Ptk2b Nfkb1 Grb2 Stat5a Stat5b Raf1 Stat3 Mapk9 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP504%RATTUS NORVEGICUS Fatty acid biosynthesis Echs1 Pc Scd1 Hadh Mecr Echdc3 Echdc1 Echdc2 Acaa2 Acsl1 Decr1 Fasn Acsl5 Acsl6 Acly Acsl3 Acacb Acaca MIR219 IN OLIGODENDROCYTE DIFFERENTIATION AND MYELINATION%WIKIPATHWAYS_20260810%WP2811%RATTUS NORVEGICUS mir219 in oligodendrocyte differentiation and myelination Neurod1 Sox6 Hes5 Pdgfra Zbtb18 Foxj3 Elovl7 IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP8%RATTUS NORVEGICUS IL 9 signaling pathway Mapk1 Cxhxorf65 Kat5 Il9 Jak3 Il2rg Il9r Map2k1 Akt1 Irs2 Socs3 Grb2 Pik3r1 Stat5a Stat5b Mapk3 Stat3 Ptpn11 Vcp Shc1 Jak1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260810%WP473%RATTUS NORVEGICUS GPCRs class A rhodopsin like Or6b1 Gpr15 Or2c1 Or13c7d Gpr12 Adora3 Or2t1 Cckar Opn1sw Npbwr1 Nmur2 Prlhr Npy5r Ntsr2 Brs3 Gpr25 Ptger4 Mc2r Gpr27 Ptger2 Gpr22 Ptger3 Gpr21 Ptger1 Ccr9 Mchr1 Ccr7 Ccr6 Ccr3 Mtnr1a Npy4r Gpr37 Gpr39 Or11a4 Rgr Or14j1 Gper1 Mc4r Or10j27 Ptafr Npffr1 Or2f2 Npffr2 Ptgdr2 Hcrtr1 Or5ap2b Adora2b Or2w1 Adora2a Gpr37l1 P2ry6 Cysltr2 Lpar6 Cysltr1 Adora1 Npy2r P2ry2 Ackr4 P2ry1 Gpr4 Lpar4 Cnr2 Rho Gpr3 Agtr2 Ackr2 Bdkrb2 Gpr6 P2ry10 Mc3r Or2ag1 P2ry12 P2ry14 F2rl1 Cxcr1 Or10a4 Ednra Gpr50 Oprk1 Ntsr1 F2rl2 Fshr F2rl3 Ccr5 Ccr2 Cckbr Sstr2 C3ar1 C5ar2 Or3a1e Ptgfr Or2f1 Cnr1 Gpr18 Adra1a Grpr P2ry13 Gpr17 Htr2a Adra2a Htr2c Adra2c Htr1a Adra2b Htr4 F2r Hrh1 Htr6 Htr7 Hrh2 Adrb1 Drd3 Drd5 Adra1b Adrb3 Adra1d Htr1d Htr1f Htr5a Agtr1 Ptgir Mas1 Oxtr Hcar1 Ghsr Ednrb Gpr161 Npy1r Rrh Ptgdr Or3a1 Oprd1 Or2h2 Gpr65 Or2h1 Gpr68 Cxcr4 Gpr63 Oprl1 Gpr173 Gpr174 Galr2 Gpr171 Galr3 Galr1 Cmklr1 Lhcgr Sstr5 Sstr4 Sstr3 Olr226 Sstr1 Avpr1b Mc5r Oprm1 Gpr75 Tbxa2r Or7c70 Ffar3 Fpr1 Aplnr Nmbr Fpr3 Drd1 Ffar1 Bdkrb1 Fpr2 Ffar2 Drd4 Ccr10 Chrm1 Or2b2 Chrm3 Or2j3 Chrm2 Hrh3 Chrm5 Or5v1b Chrm4 Gpr85 Or7a36 Opn4 Xcr1 Lpar5 Opn3 Olr1073 Gpr19 Sucnr1 ONE CARBON METABOLISM%WIKIPATHWAYS_20260810%WP1292%RATTUS NORVEGICUS One carbon metabolism Dhfr Mat1a Mthfd1l Ahcy Folh1 Mtrr Mthfd2 Mtr Ftcd Ahcyl2 Bhmt Tcn2 Dnmt3a Aldh1l1 Shmt1 Gart Mthfr METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260810%WP1286%RATTUS NORVEGICUS Metapathway biotransformation Fmo4 Hs6st1 Cyp7a1 Naa50 Cyp26c1 Cyp46a1 Nat8 Nat1 Nat2 Ephx2 Gal3st4 Gal3st3 Nat9 Sult2b1 Cyp21a1 Cyp26b1 Cyp27b1 Sult1a1 Akr7a3 Sult1e1 Akr7a2 Cyp8b1 Gstk1 Cyp24a1 Glyat Inmt Cyp26a1 Cyp2f2 Cyp1b1 Cyp7b1 Akr1b1 Gstm5 Gstm4 Gstm1 Cyp2e1 Cyp1a1 Chst10 Chst12 Cyp2u1 Chst13 Cyp4f18 Chst14 Cyp4f17 Sult6b2 Ephx1 Naa40 Akr1a1 Ugt2b1 Cyp17a1 Nat10 Ndst1 Cyp4x1 Ndst3 Hs3st3a1 Comt Gsto1 Sult4a1 Chst1 Sult2a1 Chst3 Hnmt Mgst1 Sult2a6 Chst4 Chst6 Chst9 Akr1c1 Zfp628 Gstp1 Gstz1 Hs3st2 Sult1b1 Hs3st5 Hs3st6 Cyp2s1 Hs3st3b1 Gstm7 Cyp4f39 Baat Chst11 Naa20 Akr1d1 Gstcd Kcnab2 Cyp51a1 Gss Kcnab3 Fmo1 Hs2st1 Tpmt Fmo3 Fmo2 Akr1b10 Fmo5 Hs6st3 ANGIOTENSIN II SIGNALING ACUTE IN THICK ASCENDING LIMBS%WIKIPATHWAYS_20260810%WP3887%RATTUS NORVEGICUS Angiotensin II signaling acute in thick ascending limbs Plcg1 Mas1 Itpr2 Akt1 Calm3 Pten Calm2 Pde2a Prkaca Plcg2 Agtrap Arrb2 Nos3 Gnaq Dnm1 Akt2 Itpr3 Itpr1 Pdpk1 Nox4 Prkcg Agtr1b Agtr2 Akt3 Agtr1 Prkca TCA CYCLE%WIKIPATHWAYS_20260810%WP347%RATTUS NORVEGICUS TCA cycle Mdh1 Mdh2 Pc Pdk4 Fh Sdhc Sdhb Pdk3 Sdha Idh3b Pdk2 Afdn Pdhb Suclg1 Suclg2 Dld Pdha1 Ogdh GLUCURONIDATION%WIKIPATHWAYS_20260810%WP1276%RATTUS NORVEGICUS Glucuronidation Pgm1 Ugdh Ugt2b7 Pgm2 Pgm5 Ugt2b35 Ugt2b1 Ugt2b34 Ugt2a1 Hk1 Ugp2 WNT MYOFIBROBLASTIC ACTIVATION OF HEPATIC STELLATE CELLS%WIKIPATHWAYS_20260810%WP3649%RATTUS NORVEGICUS Wnt myofibroblastic activation of hepatic stellate cells Pparg Wnt3a ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP1299%RATTUS NORVEGICUS ErbB signaling pathway Elk1 Plcg1 Pak4 Gab1 Egf Gsk3b Camk2a Shc2 Src Eif4ebp1 Abl1 Ereg Rps6kb1 Hbegf Nrg2 Nrg1 Crk Mapk1 Jun Areg Tgfa Btc Nrg4 Nrg3 Egfr Bad Map2k1 Pik3r5 Ptk2 Hras Mtor Grb2 Mapk8 Cblc Stat5a Cdkn1b Erbb2 Map2k7 Sos1 Akt3 Prkca Cdkn1a WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP375%RATTUS NORVEGICUS Wnt signaling pathway Apc Sox9 Akt1 Tbp Jun Ccnd1 Cdh1 Tax1bp3 Skp1 Sfrp2 Sfrp1 Dkk1 Magi3 Ror2 Crybb2 Csnk1d Sall1 Cdc25c Mapk8 Senp2 Ruvbl1 Map3k7 Vangl2 Prkcg Csnk1a1 Dab2 Mapk3 Tfap2a Brd7 Jup Btrc Map1b Ctnnbip1 Prkcb Ankrd6 Rac1 Bcl9 Dlg1 Prkca Dlg2 Dlg4 Tcf4 Nr5a1 Camk2g Hipk2 Ppp2ca Camk2d Camk2b Gsk3b Cul1 Camk2a Csnk2a1 Arrb2 Mark2 Arrb1 Nlk Ctnnb1 Csnk2b Rhoa Ctbp1 Wnt5a Tmem97 Mapk1 Ctbp2 Mapk8ip1 Axin1 Axin2 Pax2 Lef1 Lrp6 Lrp5 Smad4 Wnt3a Dvl1 Dvl2 Dvl3 Raf1 Wnt7a Wnt2 Wnt4 Wnt3 Fzd2 Cdk1 Fzd4 Mapk9 Fzd9 Fzd8 CARDIOVASCULAR SIGNALING%WIKIPATHWAYS_20260810%WP590%RATTUS NORVEGICUS Cardiovascular signaling Pgf Thbs2 Akt1 Wasf1 Egf Rras2 Vav2 Col1a1 Map2k6 Col4a1 Pdgfra Vegfd Hspb1 Col4a2 Casp6 Hspa1b Stmn1 Casp3 Cfl1 Casp2 Arhgef7 Vwf Selenop Mapk8 Erbb2 Wnt2 Tnc Col11a1 Capn6 Col5a1 ATM SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP654%RATTUS NORVEGICUS ATM signaling pathway Sfnl1 Ccnd1 Ccnb1 Rb1 Chek2 Cdk6 Casp9 Casp3 Brca1 E2f1 Bax Tp53 Gadd45a Pmaip1 Ccne1 Cdk1 Cycs Necab3 Rprm Bak1 Cdkn1a PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260810%WP303%RATTUS NORVEGICUS Prostaglandin synthesis and regulation Anxa8 Anxa6 Ednrb Prl Ptgds S100a6 Scgb1a1 Ptgdr Tbxas1 Edn1 Ptgis Anxa1 Hpgd Anxa5 Ptger4 Anxa4 Anxa3 S100a10 Ptger2 Ptgs1 Ptgs2 Ptger3 Ptger1 Ptgfr Cyp11a1 Hsd11b1 Hsd11b2 Pla2g4a Ednra Ptgir SELENIUM MICRONUTRIENT NETWORK %WIKIPATHWAYS_20260810%WP1310%RATTUS NORVEGICUS Selenium micronutrient network Mtr Mt-co2 Alox5 Ptgds Cat Tbxas1 Gpx3 Ptgis Selenop Mthfr Selenok Xdh Gpx6 Fads2 Mt-co1 Gpx1 Kmo Fads1 Pnpo Sod1 OSTEOCLAST%WIKIPATHWAYS_20260810%WP489%RATTUS NORVEGICUS Osteoclast Ifnb1 Ifnar1 Itgb3 Slc9a1 Trpv5 Zcchc2 Tnfsf11 Ctsk Atp6v1e1 Spp1 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260810%WP161%RATTUS NORVEGICUS Small ligand GPCRs Ptafr Ptgdr S1pr1 Ptger4 S1pr3 Ptger2 Cnr2 Ptger3 Ptger1 Ptgfr Lpar1 Mtnr1a Cnr1 Ptgir GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260810%WP378%RATTUS NORVEGICUS GPCRs class B secretin like Adgre5 Gipr Gcgr Adgre1 Sctr Adgrl4 Adcyap1r1 Adgrl1 Glp2r Vipr1 Adgrl2 Calcrl Adgrl3 Glp1r Crhr2 Ghrhr Crhr1 Calcr BETA OXIDATION META PATHWAY%WIKIPATHWAYS_20260810%WP372%RATTUS NORVEGICUS Beta oxidation meta pathway Gcdh Lpl Lipe Echs1 Crat Cpt2 Acads Pnpla2 Hadh Acadvl Cpt1a Hadha Gpd2 Hadhb Lipf Tpi1 Acsl4 Acadm Acsl1 Acat1 Dld Acsl5 Acsl6 Acsl3 MRNA PROCESSING%WIKIPATHWAYS_20260810%WP529%RATTUS NORVEGICUS mRNA processing Rnmt Snrnp70 Clp1 Snrpb2 Xrn2 Spop Prpf8 Snrnp40 Prpf18 Hnrnpr Dhx9 Hnrnpu Papola Snrpb Snrpa1 Snrpa Clk2 Clk3 Clk4 Mettl3 Prp4k Ptbp1 Fus Sugp1 Sugp2 Srpk1 Cpsf1 Hnrnpd Cpsf2 Cpsf3 Ddx1 Snrpepl2 Hnrnpk Hnrnpm Hnrnpab Cstf1 Ybx1 Clasrp Nudt21 Tmed10 Sfpq Prmt2 Cstf2 Dhx16 Cstf3 Srsf1 Ptbp2 Srsf9 Srsf7 Srsf6 Srsf5 Srsf4 Srsf3 Srsf2 Prmt1 Srek1 Srsf10 Srrm1 Rbm17 U2af1 Nxf1 Sf3a1 Sf3a2 Sf3a3 U2af2 Ncbp2 Ncbp1 Cd2bp2 Rbmx Snrpd1 Tra2b Celf4 Celf2 Pabpn1 Snrpd3 Sf3b2 Sf3b3 Sf3b4 Rbm39 Sfswap Sf3b5 Srp54 Hnrnph2 Ppm1g Hnrnph1 Dicer1 Ddx20 Rngtt Smc1a Celf1 Prpf4 Phf5a Prpf6 Prpf3 Prpf40a Scamp3 Hnrnpa2b1 Supt5h Cdc40 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP569%RATTUS NORVEGICUS IL 2 signaling pathway Ets2 Akt1 Crkl Il2 Syk Rack1 Lck Crk Mapk14 Cxhxorf65 Il2ra Ptpn6 Ybx1 Il2rg Irs2 Socs3 Mtor Mapk8 Mapk3 Nr3c1 Jak2 Foxo3 Jak1 Eif3b Jak3 Gab2 Eif4e Prkcz Pik3r1 Pik3cd Pik3r2 Pik3ca Stam2 Cd53 Itm2b Pik3cg Stam Rps6kb1 Nmi Ptpn11 Shc1 Mapk1 Fyn Lyn Mknk1 Mapkapk2 Rela Map2k1 Ptk2b Plcb1 Nfkb1 Tert Grb2 Stat5a Stat5b Chuk Raf1 Sos1 Stat3 Mapk9 BIOSYNTHESIS OF ALDOSTERONE AND CORTISOL%WIKIPATHWAYS_20260810%WP508%RATTUS NORVEGICUS Biosynthesis of aldosterone and cortisol Hsd3b6 Cyp17a1 Cyp21a1 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260810%WP278%RATTUS NORVEGICUS Matrix metalloproteinases Mmp24 Mmp14 Mmp15 Mmp16 Tnf Mmp28 Timp3 Timp2 Timp4 Bsg Tcf20 Mmp21 Mmp2 Mmp9 Mmp11 Cep295nl Mmp23 ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260810%WP4268%RATTUS NORVEGICUS Ethanol metabolism resulting in production of ROS by CYP2E1 Mapk8 Mafg Cyp2e1 Nfe2l2 Map2k1 Prkcb RELATIONSHIP BETWEEN GLUTATHIONE AND NADPH%WIKIPATHWAYS_20260810%WP2562%RATTUS NORVEGICUS Relationship between glutathione and NADPH Gsn Map3k5 Ugp2 Anpep Pgm1 Pgm2 Dffa Dffb Alox5 Bax Fth1 Tp53 Mapk8 Gpi Abcc1 Pfkl Txn Eno1 Gclm Pgam2 Gapdh Pklr Pgk1 Ftl1 Ugdh Casp3 Gstp1 Nnt Ptgr1 Tfr2 Gapdhl6 Dpep2 Ugt8 Ltc4s Tfrc Gck Aldoa Rpia Rpe Nqo1 G6pdx Taldo1 Gss Pgls Kif1b Tkt Pgd Fas Cdkn1a INTRACELLULAR TRAFFICKING OF CFTR%WIKIPATHWAYS_20260810%WP1486%RATTUS NORVEGICUS Intracellular trafficking of CFTR Ezr Fblim1 Rab7a Rab11a Cftr Nherf1 THICK ASCENDING LIMB TRANSPORTERS%WIKIPATHWAYS_20260810%WP3882%RATTUS NORVEGICUS Thick ascending limb transporters Ca4 Slc12a7 Kcnj16 Clcnkb Clcnka Kcnq1 Slc4a7 Slc12a1 Atp1b1 Slc9a2 Slc9a3 Atp1a1 Aqp1 Kcnk12 Ca2 PEPTIDE GPCRS%WIKIPATHWAYS_20260810%WP131%RATTUS NORVEGICUS Peptide GPCRs Cxcr6 Tacr3 Cckar Tacr2 Tshr Tac4 Npy5r Tacr1 Ntsr2 Brs3 Mc2r Ccr7 Ccr6 Ccr3 Npy4r Oxtr Mc4r Npy2r Agtr2 Bdkrb2 Mc3r Cxcr1 Ednra Gnrhr Oprk1 Ntsr1 Fshr Ccr5 Ccr2 Ghsr Ednrb Cckbr Npy1r Sstr2 Oprd1 C3ar1 Cxcr4 Oprl1 Galr2 Galr3 Galr1 Lhcgr Sstr5 Sstr4 Grpr Sstr3 Sstr1 Avpr1b Mc5r Oprm1 Fpr1 Nmbr Fpr3 Bdkrb1 Fpr2 Ccr10 Agtr1 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260810%WP348%RATTUS NORVEGICUS G1 to S cell cycle control Mnat1 Pcna Ccna1 Ccne2 Ccnh Cdkn2b Tfdp1 Cdkn2c Cldn5 Myt1 Gadd45a Mcm4 Mcm6 Mcm2 Pole2 Pola2 Ccng2 Creb3l4 Creb3l1 Orc5 Atf6b Rpa3l1 Orc4 Orc6 Orc1 Orc3 Rpa2 Wee1 E2f2 Ccnd1 E2f3 E2f4 E2f6 Pole Cdkn1c Cdk7 E2f1 E2f5 Tp53 Cdkn1b Creb3 Ccnb1 Cdk6 Mcm7 Ccne1 Mcm5 Rb1 Rbl1 Mdm2 Cdk1 Necab3 Cdkn1a G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP520%RATTUS NORVEGICUS G13 signaling pathway Pak3 Mapk10 Limk1 Pik3cd Rock2 Rock1 Pik3r2 Rps6kb1 Tnk2 Arhgdib Iqgap2 Ppp1cb Cdc42 Cfl2 Wasl Sh3rf1 Cit Diaph1 Cyfip1 Pip4k2a Mybph Arhgef1 Pkn1 Map3k4 Rac1 G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260810%WP73%RATTUS NORVEGICUS G protein signaling pathways Gna13 Prkaca Gnaq Gngt1 Gnb2 Gnb3 Prkd3 Gng13 Ppp3cc Itpr1 Gnb1 Hras Pde7b Gnai1 Pde7a Adcy3 Prkcq Akap7 Adcy4 Gnai3 Akap3 Adcy2 Akap4 Prkcg Akap1 Adcy7 Gnaz Akap10 Akap11 Adcy5 Akap12 Prkci Akap9 Nras Akap13 Prkcb Adcy9 Pde8a Prkce Pde8b Pde4b Kcnj3 Prkca Prkacb Pakap Prkar1a Gna14 Gnao1 Gnal Gng5 Pde4c Gnas Gng3 Pde1c Pde1a Gng11 Gna12 Prkcz Prkcd Pde4d Gng8 Prkar2b Akap8 Rhoa Ppp3ca Plcb3 Rras Adcy8 Arhgef1 Prkar1b Slc9a1 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260810%WP360%RATTUS NORVEGICUS Acetylcholine synthesis Ache Pcyt1a Ahsg Pdha1 Chat Pemt PROXIMAL TUBULE TRANSPORTERS%WIKIPATHWAYS_20260810%WP3881%RATTUS NORVEGICUS Proximal tubule transporters Ca4 Slc20a2 Slc22a6 Car15 Slc26a1 Fxyd4 Slc22a5 Tctn2 Atp6v0a2 Atp6v0a4 Atp6v1g3 Slc34a1 Atp6v0e2 Atp6v0a1 Slc1a1 Atp6v0c Car7 Slc4a4 Slc38a7 Atp6v1e1 Slc6a19 Slc7a6 Slc7a7 Slc9a8 Slc13a3 Slc7a8 Atp6v1a Slc13a1 Slc7a9 Slc34a2 Slc13a2 Atp6v1b2 Atp6v0d2 Atp6v0d1 Nherf2 Atp6v1b1 Nherf1 Slc16a10 Atp6v1g1 Slc22a8 Atp6v1d Ca14 Atp6v1h Atp1b1 Slc9a3 Atp1a1 Ca2 GENETIC ALTERATIONS OF LUNG CANCER%WIKIPATHWAYS_20260810%WP1968%RATTUS NORVEGICUS Genetic alterations of lung cancer Mapk1 Ccnd1 Rb1 Tgfb2 Egfr Crebbp Map2k1 Akt1 E2f1 Smad4 Tp53 Pik3cd Erbb2 Raf1 Pik3ca Dmp1 Mycb Rasl11b Smad2 Tgfb1 Mdm2 Ccne1 Necab3 Cdkn1a LIPID DROPLET METABOLISM%WIKIPATHWAYS_20260810%WP3901%RATTUS NORVEGICUS Lipid droplet metabolism Soat1 Agpat2 Plin2 Bscl2 Pnpla2 Gpd2 Acsl1 Aup1 Lpin3 Gpat2 Lipa Dgat2 Lpin1 Agpat5 Acsl3 Dgat1 Agpat3 Fitm2 Agpat4 Agpat1 FOLIC ACID NETWORK%WIKIPATHWAYS_20260810%WP1311%RATTUS NORVEGICUS Folic acid network Cbs Mtr Msrb1 Mt-co2 Alox5 Ptgds Cat Gpx3 Ptgis Txnrd2 Mthfr Selenok Xdh Gpx6 Fads2 Mt-co1 Gpx1 Kmo Selenow Pnpo Sod1 P53 PATHWAY%WIKIPATHWAYS_20260810%WP655%RATTUS NORVEGICUS p53 pathway Sesn1 Zmat3 Sfnl1 Serpinb5 Ccnb1 Chek2 Igfbp3 Cdkn2a Shisa5 Cdk6 Adgrb1 Cd82 Mdm4 Ppm1d Pten Rchy1 Ccng1 Gadd45a Ccne1 Cycs Tp73 Chek1 Casp9 Casp3 Bax Tp53 Tsc2 Siah1 Perp Pmaip1 Cdk1 Fas Bid Serpine1 Rprm Cdkn1a NUCLEAR RECEPTORS%WIKIPATHWAYS_20260810%WP217%RATTUS NORVEGICUS Nuclear receptors Nr5a1 Nr2e1 Hnf4a Nr2f1 Esrrb Nr2f6 Thrb Nr1d2 Thra Nr2f2 Rara Rorc Nr1h2 Esr2 Ror1 Nr5a2 Nr2c2 Nr4a2 Nr1i3 Rxra Nr1i2 Ppard Rarb Esr1 Rxrb Vdr Nr1h3 Ppara Pparg Rxrg Nr3c1 Esrra HYPERTROPHY MODEL%WIKIPATHWAYS_20260810%WP442%RATTUS NORVEGICUS Hypertrophy model Jund Ifng Eif4e Atf3 Eif4ebp1 Il1a Il1r1 Myog Wdr1 Ankrd1 Zeb1 Dusp14l1 Hbegf Ifrd1 Ccn1 Nr4a3 BURN WOUND HEALING%WIKIPATHWAYS_20260810%WP5057%RATTUS NORVEGICUS Burn wound healing Acta1 Gpr176 Ptgis Pdgfa Syk Col1a1 Il1b Col4a1 Ankrd1 Mmp9 Cdc25b Il10 Jun Arfgap1 Igf1 Ccn2 Epo Chp1 Syp Il1rl1 Glb1 Casp3 Adora2b Tp53 Dll4 HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP574%RATTUS NORVEGICUS Hedgehog signaling pathway Igf2 Ccnb1 Crebbp Hhip Gli1 Gli3 Gli2 Ski Shh Ptch2 Smo Ptch1 Sufu Sap18 Dyrk1a Cdk1}