GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260410%WP42%RATTUS NORVEGICUS GPCRs class C metabotropic glutamate pheromone Grm7 Gabbr1 Grm6 Gabbr2 Grm8 Gprc5b Gprc5a Casr Gprc5d Grm1 Gprc5c Grm3 Grm2 Grm5 Grm4 VEGF RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260410%WP1965%RATTUS NORVEGICUS VEGF receptor signal transduction Sh2d2a Mapkapk2 Casp9 Bad Nos3 Shc1 Src Pxn Mapk1 Plcg1 Pgf Prkci Akt1 Grb2 Rac1 Hspbp1 Prkca Raf1 Vegfc Pik3r3 Vegfb WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP375%RATTUS NORVEGICUS Wnt signaling pathway Rhoa Mapk3 Mark2 Ctbp1 Wnt5a Cdh1 Ctbp2 Sox9 Tax1bp3 Skp1 Sfrp2 Csnk2b Ppp2ca Sfrp1 Tbp Dkk1 Pax2 Gsk3b Prkcg Prkcb Magi3 Axin1 Axin2 Ror2 Crybb2 Csnk1d Btrc Sall1 Cdc25c Senp2 Lef1 Ruvbl1 Vangl2 Lrp6 Csnk1a1 Nlk Dab2 Camk2g Lrp5 Camk2d Tfap2a Camk2b Camk2a Wnt3a Dvl1 Arrb2 Dvl2 Tmem97 Dvl3 Arrb1 Wnt7a Brd7 Wnt2 Wnt4 Wnt3 Jun Fzd2 Jup Ccnd1 Fzd4 Map1b Fzd9 Fzd8 Ctnnbip1 Ankrd6 Bcl9 Dlg1 Smad4 Dlg2 Mapk8ip1 Apc Dlg4 Cul1 Cdk1 Tcf4 Nr5a1 Hipk2 Mapk1 Akt1 Rac1 Prkca Raf1 Mapk9 Mapk8 Csnk2a2 Ctnnb1 Csnk2a1 Map3k7 PROXIMAL TUBULE TRANSPORTERS%WIKIPATHWAYS_20260410%WP3881%RATTUS NORVEGICUS Proximal tubule transporters Slc20a2 Slc22a6 Car15 Slc26a1 Atp1a1 Fxyd4 Slc22a5 Tctn2 Atp6v0a2 Atp6v0a4 Atp6v1e1 Atp6v1g3 Atp6v0e2 Atp6v0a1 Nherf2 Nherf1 Slc1a1 Atp6v0c Car7 Slc4a4 Slc38a7 Slc34a1 Slc6a19 Slc7a6 Slc7a7 Car2 Atp1b1 Slc9a3 Slc9a8 Slc13a3 Slc7a8 Atp6v1a Slc13a1 Slc7a9 Slc34a2 Slc13a2 Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Slc16a10 Atp6v1g1 Ca4 Slc22a8 Atp6v1d Ca14 Atp6v1h GLUCURONIDATION%WIKIPATHWAYS_20260410%WP1276%RATTUS NORVEGICUS Glucuronidation Ugt2b35 Ugt2b34 Ugt2a1 Ugp2 Ugdh Pgm1 Hk1 Ugt2b1 Ugt2b7 Pgm2 Pgm5 STATIN PATHWAY%WIKIPATHWAYS_20260410%WP145%RATTUS NORVEGICUS Statin pathway Lcat Abca1 Scarb1 Apoc1 Mttp Soat1 Hmgcr Lpl Apoe Cyp7a1 ATM SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP654%RATTUS NORVEGICUS ATM signaling pathway Cdkn1a Tp53 Rprm Casp9 Cdk1 Rb1 Sfnl1 Ccnb1 Ccne1 Casp3 Cycs Chek2 Gadd45a Necab3 Ccnd1 Cdk6 Brca1 Pmaip1 Bax E2f1 Bak1 TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260410%WP1280%RATTUS NORVEGICUS Transcriptional activation by Nfe2l2 in response to phytochemicals Nqo1 Aimp2 Maf Prkca Hmox1 Gclm Cebpb Nfe2l2 Ephb2 Mapk8 KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP147%RATTUS NORVEGICUS Kit receptor signaling pathway Prkcb Socs1 Stap1 Mitf Grb10 Socs5 Socs4 Matk Socs6 Crkl Ptpru Csf2rb Cltc Jak2 Sh3kbp1 Cblb Vav2 Fgr Dok1 Hck Rps6ka1 Kit Tnfrsf10b Btk Spred1 Pik3r1 Mpdz Crk Sos1 Pik3r2 Spred2 Grb7 Rasa1 Ptpn6 Ptpn11 Abl1 Pik3cg Fyn Grap Lyn Plce1 Sh2b2 Stat5a Stat5b Map2k1 Tec Fes Stat3 Hras Bad Shc1 Src Mapk1 Plcg1 Akt1 Grb2 Prkca Raf1 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260410%WP139%RATTUS NORVEGICUS Nuclear receptors in lipid metabolism and toxicity Abca1 Cyp7a1 Nr1i3 Nr1i2 Abcb1a Abcd2 Cyp27b1 Abcd3 Cyp2c11 Abcb4 Cyp4b1 Rara Rarb Cyp2b2 Cyp8b1 Vdr Nr1h3 Ppard Ppara Pparg Abcg1 Abcc3 Cyp24a1 Abcg5 Abcc2 Cyp26a1 Cyp2e1 Abcb11 SELENIUM MICRONUTRIENT NETWORK %WIKIPATHWAYS_20260410%WP1310%RATTUS NORVEGICUS Selenium micronutrient network Tbxt Sod1 Ptgds Fads1 Ptgis Cat Pnpo Xdh Mt-co2 Mthfr Selenok Fads2 Tbxas1 Mt-co1 Gpx1 Selenop Gpx3 Gpx6 Alox5 Gsr Mtr Kmo GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260410%WP378%RATTUS NORVEGICUS GPCRs class B secretin like Calcr Adgre5 Ghrhr Gipr Gcgr Adgre1 Adgrl2 Adgrl3 Sctr Adgrl4 Adcyap1r1 Adgrl1 Glp2r Vipr1 Calcrl Glp1r Crhr2 Crhr1 CARDIOVASCULAR SIGNALING%WIKIPATHWAYS_20260410%WP590%RATTUS NORVEGICUS Cardiovascular signaling Casp3 Arhgef7 Erbb2 Col11a1 Stmn1 Hspa1b Tnc Map2k6 Pdgfra Hspb1 Rras2 Vegfd Col1a1 Wasf1 Vwf Egf Col4a1 Casp6 Capn6 Col5a1 Pgf Col4a2 Akt1 Cfl1 Casp2 Wnt2b Wnt2 Thbs2 Selenop Vav2 Mapk8 FRUCTOSE METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260410%WP3894%RATTUS NORVEGICUS Fructose metabolism in proximal tubules Tkfc Naglt1 Akr1b1 Fbp1 Slc2a5 Pfkp Hk1 Gpi Slc5a9 Tpi1 Psme3 Slc5a10 Sord Aldob G6pc1 Aldoa Khk Pfkl NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP517%RATTUS NORVEGICUS Notch signaling pathway Ctbp1 Aph1a Ctbp2 Ncstn Ncor2 Dtx2 Dtx3 Dtx4 Dll3 Dll4 Rbpjl Maml1 Dtx3l Hdac1 Mfng Hes1 Numb Hes5 Jag2 Jag1 Kat2a Rfng Crebbp Notch4 Numbl Notch1 Notch2 Lfng Notch3 Psen1 Psen2 Dvl1 Dvl2 Dvl3 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260410%WP547%RATTUS NORVEGICUS Complement and coagulation cascades Klkb1 Kng2 C2 Proc C6 C9 Serpind1 F13b Cd46 F10 C1s C1r F12 Plat Thbd Plau Pros1 Serpinc1 A2m Cpb2 Cd55 C1qc Vwf Cr2 Serping1 Cr1l Kng2l1 C3ar1 Serpinf2 Mbl1 Fgb Masp1 Masp2 Tfpi F2 C8b F3 C4a F7 F8 F9 Serpine1 Plaur Cfb C1qb Cfd C1qa Cd59b Cfh Cfi F2r Plg SMALL LIGAND GPCRS%WIKIPATHWAYS_20260410%WP161%RATTUS NORVEGICUS Small ligand GPCRs Ptger1 S1pr1 S1pr3 Lpar1 Mtnr1a Cnr1 Cnr2 Ptgdr Ptgir Ptger4 Ptgfr Ptger2 Ptafr Ptger3 HYPOTHETICAL NETWORK FOR DRUG ADDICTION%WIKIPATHWAYS_20260410%WP1281%RATTUS NORVEGICUS Hypothetical network for drug addiction Mapk3 Map2k1 Grm1 Grm5 Grin2a Camk4 Adcy1 Drd1 Grin1 Camk2b Adcy8 Drd4 Acta1 Nisch Mapk1 Krit1 Prkaca Terf2ip Gria2 Gria1 Ppa1 Prkce Grin2d Grin2c Grin2b INSULIN INDUCED PI3K AKT AND MAPK IN HEPATOCYTES%WIKIPATHWAYS_20260410%WP4229%RATTUS NORVEGICUS Insulin induced PI3K Akt and MAPK in hepatocytes Gys2 Mapk3 Rheb Rps6kb1 Foxk1 Foxo1 Akt1s1 Rps6 Sos1 Tsc2 Tsc1 Eif4e Gsk3a Mlst8 Bad Shc1 Mapk1 Grb10 Akt1 Grb2 Raf1 Rptor Ins1 Eif4ebp1 Irs2 Pik3c3 Mtor Acly Pfkfb2 Rps6ka1 Gys1 BIOSYNTHESIS OF ALDOSTERONE AND CORTISOL%WIKIPATHWAYS_20260410%WP508%RATTUS NORVEGICUS Biosynthesis of aldosterone and cortisol Cyp21a1 Hsd3b2 Cyp11b2 Cyp17a1 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260410%WP278%RATTUS NORVEGICUS Matrix metalloproteinases Tcf20 Mmp21 Mmp11 Cep295nl Mmp23 Mmp24 Mmp14 Mmp15 Mmp16 Mmp2 Mmp28 Mmp17 Timp3 Timp2 Timp4 Tnf Mmp9 Bsg TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260410%WP1289%RATTUS NORVEGICUS Type II interferon signaling IFNG Ptpn11 Socs3 Spi1 Cxcl10 Eif2ak2 Cxcl9 Ifnb1 Ifng Ifngr2 Oas1a Socs1 Ifngr1 Psmb9 Gbp1 Jak1 Nos2 Tap1 Ciita Irf4 Prkcd Reg1a Cybb Il1b Jak2 Irf1 Irf2 Irf8 Isg15 Hist1h2ao Irf9 Ifit2 HEXOSES METABOLISM IN PROXIMAL TUBULES%WIKIPATHWAYS_20260410%WP3916%RATTUS NORVEGICUS Hexoses metabolism in proximal tubules Eno3 Eno2 Pc Mpc1 Mpc2 Pdk4 Pgam2 Hk1 Slc2a2 Pdk3 Pgam1 Pdk2 Pdk1 Pdhb Gapdh Ldha Ldhb Dld Pklr Aldoc Pdha1 Pgk1 Slc5a1 Pck1 Slc5a2 Got1 Mdh1 Mdh2 Got2 Pdp1 Pdp2 Gpi Slc5a9 Tpi1 Psme3 Slc5a10 Sord Aldob G6pc1 Aldoa Acly Khk Pfkl Tkfc Akr1b1 Fbp1 Slc2a5 Pfkp Pdhx Eno1 BETA OXIDATION OF UNSATURATED FATTY ACIDS%WIKIPATHWAYS_20260410%WP418%RATTUS NORVEGICUS Beta oxidation of unsaturated fatty acids Eci1 Acadm Decr1 Hadha Hadhb G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP520%RATTUS NORVEGICUS G13 signaling pathway Rps6kb1 Pik3r2 Arhgef1 Arhgdib Map3k4 Iqgap1 Pak3 Pik3cd Iqgap2 Cdc42 Ppp1cb Diaph1 Tnk2 Cfl2 Rhpn2 Wasl Sh3rf1 Cit Rac1 Limk1 Cyfip1 Rock2 Rock1 Mybph Pkn1 Mapk10 Pip4k2a VEGFR 3 SIGNALING%WIKIPATHWAYS_20260410%WP1964%RATTUS NORVEGICUS VEGFR 3 signaling Mapk3 Casp9 Vegfd Bad Nos3 Shc1 Mapk1 Plcg1 Pik3cg Akt1 Grb2 Vegfc Itpkc Flt4 METHYLATION%WIKIPATHWAYS_20260410%WP1282%RATTUS NORVEGICUS Methylation Mat1a Inmt Hnmt Comt Pnmt Mat2a HYPERTROPHY MODEL%WIKIPATHWAYS_20260410%WP442%RATTUS NORVEGICUS Hypertrophy model Myog Jund Wdr1 Ankrd1 Hbegf Zeb1 Ifng Eif4e Il1a Dusp14l1 Ifrd1 Il1r1 Ccn1 Nr4a3 Atf3 Eif4ebp1 INSULIN SIGNALING%WIKIPATHWAYS_20260410%WP439%RATTUS NORVEGICUS Insulin signaling Mapk3 Gsk3b Prkcb Map2k6 Map3k4 Pik3cd Jun Mapk10 Pfkl Cyth3 Grb14 Trib3 Map3k9 Map3k8 Elk1 Map3k6 Map3k5 Mapk4 Stxbp1 Stxbp2 Stxbp3 Stxbp4 Prkaa1 Prkaa2 Akt2 Gyg1 Kif5b Cblc Prkcq Map3k3 Map3k2 Prkch Map3k1 Shc3 Shc2 Insr Flot2 Flot1 Map4k5 Map4k4 Map4k3 Rab4a Rps6kb2 Prkcz Egr1 Xbp1 Kif3a Tbc1d4 Pik3c2a Pik3c2g Map4k2 Ehd1 Map4k1 Ehd2 Snap25 Snap23 Lipe Igf1r Ikbkb Arf1 Pdpk1 Rhoj Rac2 Slc2a1 Slc2a4 Ptprf Foxo3 Cap1 Rrad Inpp4a Gab1 Fos Ppp1r3a Vamp2 Rps6ka3 Rps6ka4 Rps6ka5 Rps6ka6 Mink1 Rps6ka2 Sgk3 Sos2 Sgk2 Sgk1 Myo1c Enpp1 Map2k7 Ptpn1 Stx4 Arhgap33 Inppl1 Mapk12 Mapk13 Mapk14 Pten Map2k4 Map2k2 Rapgef1 Map3k10 Map3k11 Socs1 Map3k13 Map3k14 Mapk11 Grb10 Rptor Cblb Eif4ebp1 Irs2 Pik3c3 Mtor Rps6ka1 Gys1 Gys2 Rheb Rps6kb1 Pik3r1 Foxo1 Crk Sos1 Tsc2 Pik3r2 Tsc1 Eif4e Gsk3a Ptpn11 Pik3cg Sh2b2 Map2k1 Hras Shc1 Mapk1 Prkci Akt1 Grb2 Prkcd Rac1 Reg1a Prkca Raf1 Mapk9 Mapk8 Map3k7 RETINOL METABOLISM%WIKIPATHWAYS_20260410%WP1297%RATTUS NORVEGICUS Retinol metabolism Rxra Rbp4 Retsat Crabp2 Cd36 Rxrg Lrat Rlbp1 Scarb1 Lpl Rara Rarb Dhrs3 Aldh1a1 Sult2b1 Abcg5 Cd36l1 Rdh12 Cyp26a1 Aldh1a3 Cyp2e1 Rdh10 Adh5 Adh4 Cyp26b1 Adh1 Bco1 Sult1a1 Npc1l1 Rpe65 Rxrb Rbp7 Abcg8 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260410%WP1277%RATTUS NORVEGICUS Non homologous end joining Xrcc6 Rad50 Prkdc Xrcc4 GENETIC ALTERATIONS OF LUNG CANCER%WIKIPATHWAYS_20260410%WP1968%RATTUS NORVEGICUS Genetic alterations of lung cancer Cdkn1a Tp53 Smad4 Pik3cd Pik3ca Mapk1 Bmyc Dmp1 Egfr Rasl11b Rb1 Smad2 Akt1 Tgfb1 Tgfb2 Ccne1 Mdm2 Map2k1 Raf1 Necab3 Ccnd1 Crebbp Erbb2 E2f1 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP294%RATTUS NORVEGICUS p38 Mapk signaling pathway Map3k9 Tgfb2 Rps6ka5 Atf2 Elk1 Max Pla2g4a Map3k5 Mef2d Tradd Traf2 Hras Ripk1 Mapkapk5 Mknk1 Tgfbr1 Daxx Map2k6 Mapk14 Hspb1 Mapkapk2 Map2k4 Map3k1 Shc1 Cdc42 Grb2 Rac1 Map3k7 FOLIC ACID NETWORK%WIKIPATHWAYS_20260410%WP1311%RATTUS NORVEGICUS Folic acid network Msrb1 Tbxt Selenow Sod1 Ptgds Txnrd2 Cbs Ptgis Cat Pnpo Xdh Mt-co2 Mthfr Selenok Fads2 Mt-co1 Gpx1 Gpx3 Gpx6 Alox5 Gsr Mtr Kmo RELATIONSHIP BETWEEN GLUTATHIONE AND NADPH%WIKIPATHWAYS_20260410%WP2562%RATTUS NORVEGICUS Relationship between glutathione and NADPH Ugp2 Ugdh Pgm1 Pgam2 Gapdh Pklr Pgk1 Casp3 Bax Cdkn1a Tp53 Nqo1 Gclm Gpi Aldoa Pfkl Map3k5 Txn1 Ftl1 Nnt Fth1 Ptgr1 G6pd Kif1b Pgd Abcc1 Tfr2 Gstp1 Tkt Gapdhl6 Rpe Taldo1 Dpep2 Rpia Ugt8 Ltc4s Gsn Tfrc Gss Anpep Mapk8 Gck Alox5 Fas Gsr Pgls Pgm2 Dffa Eno1 Dffb NUCLEAR RECEPTORS%WIKIPATHWAYS_20260410%WP217%RATTUS NORVEGICUS Nuclear receptors Nr3c1 Rxra Nr2c2 Nr2e1 Hnf4a Esrra Esrrb Rxrg Nr2f6 Thrb Nr1d2 Thra Nr2f2 Nr2f1 Nr5a1 Rorc Nr1h2 Esr1 Esr2 Ror1 Nr5a2 Nr4a2 Nr1i3 Nr1i2 Rara Rarb Vdr Nr1h3 Ppard Ppara Pparg Rxrb APOPTOSIS%WIKIPATHWAYS_20260410%WP1290%RATTUS NORVEGICUS Apoptosis Igf1r Ikbkb Ikbkg Prf1 Birc5 Casp3 Tnfrsf1b Hells Bcl2l11 Tnfrsf1a Nfkb1 Traf1 Bcl2l2 Pmaip1 Xiap Bax Rela Bnip3l Bak1 Irf3 Tp53 Lta Irf7 Irf5 Fadd Irf6 Diablol1 Map2k4 Bid Tp73 Nfkbib Casp7 Tnfrsf25 Igf2 Nfkbia Chuk Faslg Tp63 Casp2 Jun Mapk10 Tnfrsf10b Pik3r1 Tradd Traf2 Ripk1 Map3k1 Casp9 Bad Akt1 Irf4 Irf1 Irf2 Fas Dffa Dffb ESTROGEN METABOLISM%WIKIPATHWAYS_20260410%WP1302%RATTUS NORVEGICUS Estrogen metabolism Sult1e1 Gstm1 Nqo1 Arsl Cyp1a1 Cyp1b1 Sult1a1 Comt GLUCOCORTICOID EFFECT ON TARGET GENE EXPRESSION%WIKIPATHWAYS_20260410%WP1963%RATTUS NORVEGICUS Glucocorticoid effect on target gene expression Nr3c1 Tsc22d3 Hspa4 Pla2g4a Rras Mt-co2 Anxa1 Nfkb1 Fkbp4 Nfkbia MIR219 IN OLIGODENDROCYTE DIFFERENTIATION AND MYELINATION%WIKIPATHWAYS_20260410%WP2811%RATTUS NORVEGICUS mir219 in oligodendrocyte differentiation and myelination Pdgfra Hes5 Zbtb18 Foxj3 Elovl7 Neurod1 Sox6 IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP44%RATTUS NORVEGICUS IL 5 signaling pathway Mapk3 Foxo3 Gsk3b Prkcb Nfkb1 Bax Mapk14 Rapgef1 Socs1 Nfkbia Crkl Jak2 Jun Hck Rps6ka1 Rap1gap Itgam Btk Pim1 Sox4 Pik3r1 Sdcbp Alox5ap Syk Hcls1 Pik3r2 Itgb2 Il5ra Gsk3a Unc119 Ptpn6 Il5 Ptpn11 Ptk2b Cdkn1b Pik3cg Lyn Sh2b2 Stat5a Atf2 Elk1 Stat5b Pla2g4a Stat3 Hras Shc2 Shc1 Mapk1 Jak1 Akt1 Grb2 Rac1 Prkcd Raf1 Mapk9 Alox5 Ctnnb1 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP94%RATTUS NORVEGICUS Hepatocyte growth factor receptor signaling Mapk3 Crk Sos1 Rasa1 Ptpn11 Pik3ca Ptk2b Gab1 Dock1 Fos Pak1 Itga1 Rap1a Rap1b Hgf Ptk2 Elk1 Itgb1 Map2k1 Met Stat3 Hras Pten Map2k2 Rapgef1 Src Pxn Mapk1 Grb2 Crkl Raf1 Jun Mapk8 Map4k1 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260410%WP140%RATTUS NORVEGICUS Myometrial relaxation and contraction pathways Prkcg Prkcb Nfkb1 Crhr1 Camk2g Camk2d Camk2b Camk2a Arrb2 Arrb1 Jun Atf3 Prkd1 Ets2 Rgs4 Rgs5 Rgs2 Gja1 Rgs3 Rgs1 Crcp Slc8a1 Rgs9 Rgs6 Rgs7 Prkcq Plcg2 Actb Myl4 Prkch Mylk2 Myl2 Rxfp2 Rxfp1 Atf5 Maff Pkib Calca Il6 Grk5 Grk4 Atf6b Prkcz Gnaq Pkia Grk6 Pkig Actg1 Gngt1 Oxtr Gucy1a1 Dgkz Gnb2 Gnb1 Gnb4 Gnb3 Rln1 Gng12 Itpr3 Gng13 Itpr1 Ryr2 Plcb3 Atp2a3 Atp2a2 Ywhaq Oxt Adm Ywhah Ywhag Gabpa Fos Ywhae Gsto1 Ywhab Adcy3 Adcy4 Nos1 Adcy2 Guca2b Adcy7 Guca2a Adcy5 Creb3 Adcy9 Cald1 Pde4b Prkacb Crh Prkar1a Prkar1b Rgs20 Lpar1 Rgs17 Igfbp3 Gng3 Adcy1 Rgs19 Gng2 Igfbp4 Vkorc1l1 Rgs14 Acta1 Gng7 Igfbp1 Rgs16 Pde4d Gng8 Actc1 Prkar2b Rgs10 Prkce Ackr5 Corin Ramp3 Atf2 Nos3 Plcg1 Prkcd Prkca Il1b SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260410%WP2132%RATTUS NORVEGICUS Serotonin and anxiety Prkcb Grin2d Ppp3ca Nlgn1 Adra1a Arc Plek Htr2a Htr2c Htr1a Fos Crh NUCLEAR FACTOR ERYTHROID DERIVED 2 LIKE 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP2376%RATTUS NORVEGICUS Nuclear factor erythroid derived 2 like 2 signaling pathway Mapk3 Sod1 Ldhb Gsk3b Prkcg Prkcb Map2k6 Rras2 Pik3cd Gstm1 Jun Rras Aldoa Crebbp Prkcq Actb Map3k1 Prkcz Actg1 Pik3c2a Pik3c2g Ugdh Slc2a1 Scarb1 Gsto1 Brca1 Map2k7 Cdkn1a Tp53 Nqo1 Mapk14 Hmox1 Gclm Nfe2l2 Acta1 Actc1 Prkce Pik3c3 Mapk7 Akr7a3 Akr7a2 Prkd3 Eif2ak3 Ube2k Pik3r1 Gstk1 Herpud1 Sqstm1 Acta2 Pik3r2 Prdx1 Abcc4 Nras Gstt2 Gstt1 Pik3ca Cdc34 Vcp Pmf1 Fyn Gstm5 Gstm6 Gstm3 Mafg Gstm4 Gstm2 Ubb Map2k1 Slc1a4 Mafk Actg2 Fosl1 Hras Bach1 Pik3c2b Dhcr7 Ephx1 Akr1a1 Slc35b1 Dnajc5 Aldh3a1 Xpo1 Txn1 Mgst3 Ftl1 Gsto2 Mgst2 Fth1 Mgst1 Cbr1 G6pd Gstm5l Pik3r5 Pik3r6 Abcc1 Psmc6 Mapk1 Psmc5 Abcc3 Gstp1 Psmc2 Psmc4 Prkci Psmc3 Dnajb4 Taldo1 Nqo2 Prkcd Fmo1 Sod3 Prkca Sod2 Raf1 Akr1b10 Usp14 Pik3r3 Ran Gss Mapk9 Mapk8 Gsr Map3k7 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260410%WP1301%RATTUS NORVEGICUS Mitochondrial gene expression Gabpb2 Prkar1b Tfam Pprc1 Polrmt Esrra Camk4 Gabpa Ppp3ca Tfb1m Tfb2m Mterf1 Ppargc1a Nrf1 Ppargc1b Myef2 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260410%WP502%RATTUS NORVEGICUS Nucleotide GPCRs Adora2b Adora2a P2ry6 Lpar6 Adora1 P2ry2 P2ry1 Lpar4 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260410%WP1300%RATTUS NORVEGICUS Aflatoxin B1 metabolism Akr7a2 Gstm1 Ephx1 Akr7a3 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260410%WP1296%RATTUS NORVEGICUS Homologous recombination Rad52 Pold4 Pold3 Fsbp Nbn Rad50 Pold2 Rad51 Pold1 Brca2 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260410%WP40%RATTUS NORVEGICUS Inflammatory response pathway Il2rg Lck Cd40lg Lamc1 Lamb1 Thbs1 Col1a1 Ifng Il5ra Il5 Col1a2 Cd86 Tnfrsf1b Cd40 Il4r Cd80 Tnfrsf1a Il2ra Il2rb Il2 Il4 Lama5 Vtn TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP457%RATTUS NORVEGICUS TNF alpha NF kB signaling pathway Nr2c2 Mark2 Csnk2b Ppp2ca Gsk3b Ikbkg Tnfrsf1b Tnfrsf1a Btrc Nfkb1 Rela Fadd Hspb1 Nkiras1 Nkiras2 Tbkbp1 Rps11 Nfkbib Rpl6 Casp7 Rps13 Pias3 Fbl Nfkbia Rpl30 Chuk Ube2i Dpf2 Kcnq1 Polr1b Casp2 Rnf216 Polr1a Polr1g Fbxw11 Polr1e Casp8ap2 Pkn1 Txlna Tank Gtf2i Actl6a Smarce1 Tifa Ube2d2 Polr2sl1 Flna Nfkbiz Glg1 Bag4 Ripk2 Ripk3 G3bp2 Dcaf7 Cul1 Cops3 Cav1 Capn3 Kpna6 Mcc Kpna3 Kpna2 Dap Bcl3 Hdac1 Rel Tab2 Map3k8 Ptk2 Ccar2 Traf4 Mcm7 Pfdn2 Traf6 Faf1 Crebbp Tnfrsf8 Ikbke Psmd12 Hdac2 Smarcb1 Akt2 Psmd13 Nfkb2 Alpl Rasal2 Akap8 Map3k3 Psmb5 Map3k2 Rpl8l1 Rack1 Map3k1 Cyld Fkbp5 Mcm5 Tnip2 Tnip1 Pdcd2 Nsmaf Zfand5 Commd1 Trpc4ap Psmd7 Prkcz Psmd6 Fancd2 Psmd3 Elp1 Ktn1 Pebp1 Lrpprc Mtif2 Ikbkb Ywhah Ywhag Gab1 Ywhae Ywhab Casp3 Map3k14 Prkaca Rps6kb1 Ptpn11 Cdc34 Tradd Traf2 Ripk1 Tnf Src Psmc2 Psmc3 Akt1 Csnk2a2 Csnk2a1 BETA OXIDATION META PATHWAY%WIKIPATHWAYS_20260410%WP372%RATTUS NORVEGICUS Beta oxidation meta pathway Cpt2 Acads Echs1 Cpt1a Acsl1 Gpd2 Lipf Acsl5 Acsl6 Acsl3 Acsl4 Hadh Lpl Dld Hadha Hadhb Acadm Tpi1 Pnpla2 Acadvl Acss2 Acat1 Gcdh Crat Lipe FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP504%RATTUS NORVEGICUS Fatty acid biosynthesis Decr1 Echs1 Pc Acsl1 Acsl5 Acsl6 Acsl3 Hadh Mecr Echdc3 Echdc1 Echdc2 Acaa2 Scd Fasn Acacb Acaca Acss2 Acly ID SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP397%RATTUS NORVEGICUS ID signaling pathway Igf1r Myog Smad4 Atf3 Pax2 Rb1 Hes1 Ccne1 Ccna2 Elk1 Flt1 Myod1 Elk4 Id2 Id1 Nfkb1 Kdr Id4 Id3 Tcf7l2 Rela Psmd4 Igf1 Ngf Lck Cd40lg Bmp6 Smad1 Rbl2 Bmp2 Rbl1 Pax8 Tert Smad5 Srebf1 Egf Myf5 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260410%WP1291%RATTUS NORVEGICUS Phase I biotransformations non P450 Ces2j Esd Lipa Pon3 Ces5a Pon1 Pon2 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260410%WP270%RATTUS NORVEGICUS Tryptophan metabolism Cyp4f1 Inmt Cyp2f2 Aadat Echs1 Cyp2d2 Ogdh Cyp7b1 Cat Aanat Afmid Aoc1 Dhcr24 Haao Asmt Hadh Kynu Cyp2a2 Cyp2a1 Ube3a Acmsd Ido1 Mdm2 Aldh1a1 Ddc Cyp2e1 Tph1 Cyp1a1 Aldh3a2 Cyp1b1 Aldh2 Aldh9a1 Acad10 Cyp2j3 Hsd17b10 Cyp2b15 Wars1 Cyp2j4 Prmt1 Gcdh Tdo2 IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP135%RATTUS NORVEGICUS IL 6 signaling pathway Mapk3 Foxo3 Ppp2ca Gab1 Fos Gsk3b Rb1 Casp3 Rps6ka2 Cd40 Nfkb1 Sgk1 Erbb2 Inppl1 Nlk Map2k6 Mapk14 Map3k4 Hspb1 Map2k4 Map2k2 Cebpb Tmem97 Jak2 Jun Eif4ebp1 Fgr Hck Btk Rps6kb1 Pik3r1 Foxo1 Sos1 Pik3r2 Eif4e Ptpn11 Ptk2b Fyn Hdac1 Lyn Ppp2r3b Ppp2r3a Hsp90aa1 Ptk2 Stat5a Ppp2r2c Stat5b Ppp2r2b Map2k1 Foxo4 Tec Mapt Fes Ppp2cb Stat3 Gab2 Crebbp Hras Cdk5r1 Ptpa Il6st Ppp2r5c Ppp2r5b Daxx Ppp2r5a Ncoa1 Socs3 Il6r Ppp2r2a Eif2a Bmx Mapkapk2 Cdk9 Casp9 Ppp2r1a Bad Ppp2r5e Cdk5 Shc1 Hnf1a Pxn Mapk1 Jak1 Plcg1 Il6 Akt1 Grb2 Rac1 Prkcd Raf1 Mapk8 Map3k7 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP66%RATTUS NORVEGICUS Steroid biosynthesis Hsd17b1 Hsd17b2 F13b Hsd17b7 Hsd3b5 Hsd3b2 Hsd17b3 Hsd3b1 Hsd17b4 Cyp17a1 ONE CARBON METABOLISM%WIKIPATHWAYS_20260410%WP1292%RATTUS NORVEGICUS One carbon metabolism Mat1a Gart Mthfr Mthfd1l Ahcy Folh1 Mtrr Dnmt3b Mthfd2 Ftcd Dhfr Ahcyl2 Bhmt Tcn2 Dnmt3a Mtr Aldh1l1 Shmt1 BRAIN DERIVED NEUROTROPHIC FACTOR%WIKIPATHWAYS_20260410%WP2148%RATTUS NORVEGICUS Brain derived neurotrophic factor Ngfr Ntrk2 Bdnf Serpine1 Map2k1 Raf1 Mapk1 Plat Plg PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260410%WP303%RATTUS NORVEGICUS Prostaglandin synthesis and regulation Ptgds Ednrb Ptgis Anxa8 Ednra Anxa6 Prl Cyp11a1 S100a6 Scgb1a1 Hsd11b1 Hsd11b2 Edn1 Hpgd Anxa5 Anxa4 Anxa3 S100a10 Ptgs1 Ptgs2 Pla2g4a Ptgdr Ptgir Ptger4 Ptgfr Ptger2 Ptger3 Ptger1 Tbxas1 Anxa1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260410%WP473%RATTUS NORVEGICUS GPCRs class A rhodopsin like Adora2b Ednrb Adora2a Ednra P2ry6 Lpar6 Adora1 P2ry2 P2ry1 Lpar4 Hcar1 Adra2a Ghsr Adra2c Adra2b Gpr161 Cxcr1 Npy1r Rrh Htr4 Or3a1 Htr6 Oprd1 Htr7 Or2h2 Gpr65 Or2h1 Gpr68 Cxcr4 Gpr63 Oprl1 Adrb1 Gpr173 Adra1b Gpr174 Adrb3 Galr2 Gpr171 Adra1d Galr3 Galr1 Cmklr1 Lhcgr Sstr5 Sstr4 Sstr3 Sstr2 Olr226 Sstr1 Avpr1b Mc5r Oprm1 Gpr75 Htr5a Tbxa2r C5ar2 Or7c70 Ffar3 Fpr1 Aplnr Bdkrb2 Nmbr Fpr3 Ffar1 Bdkrb1 Fpr2 Ffar2 Ccr10 Chrm1 Hrh1 Or2b2 Chrm3 Chrm2 Chrm5 Or2j3 Chrm4 Hrh2 Hrh3 Agtr1a Or5v1b Gpr85 Drd3 Or7a36 Drd5 Opn4 Xcr1 Lpar5 Opn3 Olr1073 Gper1 Gpr19 C3ar1 Sucnr1 Gpr18 Grpr Or6b1 Gpr15 Or2c1 Gpr17 Or13c7d Or5i1 Gpr12 Adora3 Or2t1 Cckar Opn1sw Npbwr1 Nmur2 Prlhr Npy5r Oxtr Ntsr2 Ntsr1 Brs3 Gpr25 Mc2r F2r Gpr27 Gpr22 Gpr21 Fshr Ccr9 Mchr1 Ccr7 Ccr6 Ccr5 Ccr3 Ccr2 Cckbr Agtr2 Npy4r Gpr37 Gpr39 Htr1d Htr1f Or11a4 Rgr Or14j1 Or3a1e Mc4r Or10j27 Mtnr1a Npffr1 Or2f2 Cnr1 Npffr2 Cnr2 Ptgdr Ptgdr2 Ptgir Or2f1 Ptger4 Rho Ptgfr Hcrtr1 Ptger2 Or5ap2b Ptafr Or2w1 Ptger3 Gpr37l1 Ptger1 Cysltr2 Cysltr1 Npy2r Ackr4 Gpr4 Gpr3 Ackr2 Drd1 Gpr6 P2ry10 Mc3r Drd4 Or2ag1 P2ry13 P2ry14 Mas1 F2rl1 Or10a4 Gpr50 Oprk1 Or10a5 F2rl2 F2rl3 Adra1a Htr2a Htr2c Htr1a ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260410%WP360%RATTUS NORVEGICUS Acetylcholine synthesis Pdha1 Ache Pcyt1a Ahsg Chat Pemt MRNA PROCESSING%WIKIPATHWAYS_20260410%WP529%RATTUS NORVEGICUS mRNA processing Rbm17 Linc00176 U2af1 Nxf1 Sf3a1 Sf3a2 Sf3a3 U2af2 Ncbp2 Ncbp1 Cd2bp2 Rbmx Snrpd1 Tra2b Celf4 Celf2 Pabpn1 Celf1 Snrpd3 Sf3b2 Sf3b3 Sf3b4 Rbm39 Sfswap Sf3b5 Srp54 Hnrnph2 Ppm1g Hnrnph1 Dicer1 Ddx20 Rngtt Smc1a Prpf4 Phf5a Prpf6 Prpf3 Prpf40a Prmt1 Scamp3 Hnrnpa2b1 Supt5h Cdc40 Rnmt Snrnp70 Clp1 Snrpb2 Xrn2 Spop Prpf8 Snrnp40 Prpf18 Dhx8 Hnrnpr Dhx9 Hnrnpu Papola Snrpb Snrpa1 Snrpa Clk2 Clk3 Clk4 Mettl3 Prp4k Ptbp1 Fus Sugp1 Sugp2 Srpk1 Cpsf4 Lsm7 Cpsf1 Hnrnpd Cpsf2 Cpsf3 Ddx1 Snrpepl2 Hnrnpk Hnrnpm Hnrnpab Cstf1 Ybx1 Clasrp Nudt21 Tmed10 Sfpq Prmt2 Cstf2 Dhx16 Cstf3 Dhx15 Srsf1 Ptbp2 Srsf9 Srsf7 Srsf6 Srsf5 Srsf4 Srsf3 Srsf2 Srek1 Srsf10 Srrm1 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP569%RATTUS NORVEGICUS IL 2 signaling pathway Nr3c1 Mapk3 Foxo3 Il2ra Nfkb1 Il2 Rela Il2rg Plcb1 Lck Jak3 Stam2 Cd53 Mapk14 Itm2b Stam Eif3b Tert Pik3cd Nmi Socs1 Chuk Crkl Jak2 Irs2 Mtor Rps6kb1 Pik3r1 Crk Syk Sos1 Pik3r2 Eif4e Ptpn6 Ptpn11 Pik3ca Ptk2b Pik3cg Fyn Lyn Stat5a Stat5b Map2k1 Ets2 Stat3 Gab2 Mknk1 Socs3 Rack1 Mapkapk2 Ybx1 Shc1 Mapk1 Jak1 Akt1 Prkcz Grb2 Raf1 Mapk9 Mapk8 INTRACELLULAR TRAFFICKING OF CFTR%WIKIPATHWAYS_20260410%WP1486%RATTUS NORVEGICUS Intracellular trafficking of CFTR Cftr Fblim1 Ezr Nherf1 Rab7a Rab11a ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP1299%RATTUS NORVEGICUS ErbB signaling pathway Rps6kb1 Crk Sos1 Hbegf Abl1 Gab1 Cdkn1b Egfr Gsk3b Ptk2 Stat5a Elk1 Map2k1 Hras Map2k7 Erbb2 Cdkn1a Cblc Bad Shc2 Camk2a Pik3r5 Src Egf Mapk1 Ereg Plcg1 Akt3 Pak4 Tgfa Nrg2 Grb2 Nrg1 Areg Btc Prkca Nrg4 Jun Nrg3 Eif4ebp1 Mapk8 Mtor REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260410%WP351%RATTUS NORVEGICUS Regulation of actin cytoskeleton Rhoa Mapk3 Arhgef7 Arhgef1 Pdgfra Rras2 Iqgap1 Pak3 Pik3cd Wasf1 Cdc42 Ezr Egf Cfl2 Pak4 Cfl1 Limk1 Rock1 Ins2 Rras Fgf2 Fgf1 Pip4k2a Fgf4 Fgf3 Fgf6 Fgf5 Fgf8 Fgf7 Fgf9 Pip4k2b Pfn1 Vcl Arhgef6 Myh10 Apc Nckap1 Pdgfrb Pdgfa Slc9a1 Ssh3 Fgfr3 Ssh2 Fgfr4 Dock1 Ssh1 Pak1 Chrm1 Itga1 Fgfr1 Fgfr2 Mylk Chrm3 Cyfip2 Chrm2 Ptk2 Arpc5 Chrm5 Cd14 Fgf16 Chrm4 Fgf17 Mapk4 Fgf14 Fgf18 Fgf19 Braf Fgf12 Fgf13 Fgf10 Fgf11 Enah Baiap2 Git1 Fgf20 Fgf23 Actb Rassf7 Gna12 Gna13 Fgd1 Bcar1 Pak6 Csk Pak2 Pak5 F2 Tmsb4x Arhgap35 Wasf2 Mos Pip5k1b Pip5k1a Actg1 Pik3c2a Pik3c2g F2r Gng12 Sos2 Ins1 Pik3c3 Pik3r1 Crk Sos1 Pik3r2 Nras Pik3ca Pik3cg Egfr Map2k1 Pik3c2b Pik3r5 Pxn Mapk1 Rac1 Raf1 Gsn Pik3r3 ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260410%WP4268%RATTUS NORVEGICUS Ethanol metabolism resulting in production of ROS by CYP2E1 Mafg Prkcb Cyp2e1 Map2k1 Nfe2l2 Mapk8 THICK ASCENDING LIMB TRANSPORTERS%WIKIPATHWAYS_20260410%WP3882%RATTUS NORVEGICUS Thick ascending limb transporters Car2 Atp1b1 Slc9a3 Atp1a1 Kcnq1 Slc4a7 Slc12a1 Slc9a2 Aqp1 Ca4 Kcnk12 Slc12a7 Kcnj16 Clcnkb Clcnka ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260410%WP557%RATTUS NORVEGICUS ACE inhibitor pathway Agt Kng2 Kng2l1 Bdkrb2 Nos3 Agtr2 Ace Agtr1b Ren PEPTIDE GPCRS%WIKIPATHWAYS_20260410%WP131%RATTUS NORVEGICUS Peptide GPCRs Gnrhr Fshr Cxcr6 Tacr1 Ednrb Ccr7 Tacr3 Ccr6 Tacr2 Ednra Ccr5 Tshr Ccr3 Tac4 Ccr2 Cckbr Agtr2 Npy4r Mc4r Ghsr Cxcr1 Npy1r Oprd1 Npy2r Cxcr4 Mc3r Oprl1 Galr2 Oprk1 Galr3 Galr1 Lhcgr Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Avpr1b Mc5r Oprm1 Fpr1 Bdkrb2 Nmbr Fpr3 Bdkrb1 Fpr2 Ccr10 Agtr1a C3ar1 Grpr Cckar Npy5r Ntsr2 Oxtr Ntsr1 Brs3 Mc2r GPCRS OTHER%WIKIPATHWAYS_20260410%WP409%RATTUS NORVEGICUS GPCRs other Gnrhr Fshr Adora2a Ednra Ccr5 Prokr2 Ccr2 Gpr162 Cckbr Adgrg1 Gpr61 Or1n1 Gpr176 Ghrhr Alg6 Gpr135 Htr1f Smo Adgrl2 Taar3 Adgrl3 Rxfp3 Taar2 Or3a1e Taar5 Gpr183 Or2a5 Hrh4 Cnr1 Gpr88 Celsr2 Or2f1 Uts2r Ltb4r2 Cxcr1 Ptgfr Lgr6 Or10a2 S1pr1 Htr7 Drd4 P2ry13 Adra1d Or10a5 Sstr2 Htr2a C5ar2 Chrm3 Chrm2 Grm1 Drd3 Grm8 Gpr18 Grpr Rxfp1 Gpr17 Ntsr1 F2r NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260410%WP146%RATTUS NORVEGICUS Nucleotide metabolism Impdh1 Nme2 Hprt1 Polg Adss2 Sat1 Srm Mthfd2 Dhfr Pold1 Prps2 Polb OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260410%WP1283%RATTUS NORVEGICUS Oxidative phosphorylation Mt-atp6 Mt-nd6 Atp5mc1 Mt-nd1 Ndufb6 Mt-nd3 Mt-nd4l Ndufb5 Mt-nd2 Ndufb8 Ndufb7 Atp5mc3 Atp5mf Atp5me Ndufv1 Ndufv3 Atp5f1a Ndufa10l1 Ndufab1 Ndufc1 Ndufc2 Ndufa2 Ndufa5 Gzmb Ndufa4 Atp5pb Gzmc Ndufa9 Ndufa8 Atp5pf Ndufb10 Atp5po Ndufs3 Ndufs2 Ndufs5 Ndufs4 Ndufs6 Mt-co3 Ndufs8 Mt-nd5 Adck2 Mt-nd4 Ndufb2 HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP574%RATTUS NORVEGICUS Hedgehog signaling pathway Cdk1 Igf2 Smo Hhip Ccnb1 Gli1 Gli3 Gli2 Ski Ptch2 Ptch1 Sufu Crebbp Sap18 Dyrk1a OSTEOCLAST%WIKIPATHWAYS_20260410%WP489%RATTUS NORVEGICUS Osteoclast Spp1 Tnfsf11 Ifnar1 Ifnb1 Atp6v1e1 Slc9a1 Trpv5 Itgb3 Zcchc2 Ctsk SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2541%RATTUS NORVEGICUS Sulindac metabolic pathway Msra Cyp1a1 Msrb2 WNT MYOFIBROBLASTIC ACTIVATION OF HEPATIC STELLATE CELLS%WIKIPATHWAYS_20260410%WP3649%RATTUS NORVEGICUS Wnt myofibroblastic activation of hepatic stellate cells Wnt3a Pparg GLUCOCORTICOID METABOLISM%WIKIPATHWAYS_20260410%WP305%RATTUS NORVEGICUS Glucocorticoid metabolism Akr1c14 Cyp11a1 Cyp21a1 Hsd11b1 Hsd11b2 Cyp17a1 P53 PATHWAY%WIKIPATHWAYS_20260410%WP655%RATTUS NORVEGICUS p53 pathway Tsc2 Cdk1 Sfnl1 Ccnb1 Ccne1 Casp3 Cycs Chek2 Gadd45a Cdk6 Pmaip1 Bax Cdkn1a Tp53 Rprm Igfbp3 Pten Sesn1 Ccng1 Bid Casp9 Chek1 Tp73 Zmat3 Serpinb5 Cdkn2a Shisa5 Adgrb1 Cd82 Perp Siah1 Mdm4 Ppm1d Rchy1 Serpine1 Fas G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260410%WP348%RATTUS NORVEGICUS G1 to S cell cycle control Mcm2 Pole2 Pola2 Ccng2 Creb3l4 Creb3l1 Orc5 Rpa3l1 Orc4 Orc6 Orc1 Orc3 Rpa2 Cdk7 Wee1 E2f2 E2f3 Rb1 E2f4 E2f5 Ccnb1 E2f6 Ccne1 Pole Cdkn1c Gadd45a Necab3 Creb3 Cdk6 E2f1 Cdkn1a Tp53 Rbl1 Ccnd1 Cdk1 Cdkn1b Mdm2 Mcm7 Mcm5 Atf6b Ccna1 Ccne2 Mnat1 Cdkn2b Tfdp1 Cdkn2c Cldn5 Pcna Ccnh Myt1 Mcm4 Mcm6 BURN WOUND HEALING%WIKIPATHWAYS_20260410%WP5057%RATTUS NORVEGICUS Burn wound healing Adora2b Ptgis Syk Ankrd1 Pdgfa Dll4 Gpr176 Casp3 Il10 Epo Arfgap1 Ccn2 Chp1 Syp Il1rl1 Glb1 Mmp9 Cdc25b Igf1 Tp53 Col1a1 Acta1 Col4a1 Il1b Jun FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260410%WP133%RATTUS NORVEGICUS Fatty acid omega oxidation Cyp3a2 Adh7 Adh6 Cyp2e1 Cyp1a1 Adh5 Adh4 Aldh2 Adh1 Acad10 Aldh1a1 Cyp4a2 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260410%WP173%RATTUS NORVEGICUS Oxidative stress response Sod1 Txnrd2 Nqo1 Nfix Mapk14 Txn2 Cyba Cat Hmox1 Junb Mgst1 Xdh Gstt2 Fos Sod3 Cyp1a1 Sod2 Mapk10 Gpx3 Nfkb1 Gsr EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP1284%RATTUS NORVEGICUS EPO receptor signaling Mapk3 Sos1 Ptprc Map2k2 Shc1 Rasa1 Socs1 Src Pdk1 Mapk1 Pik3cg Akt1 Grb2 Stat5a Ptpru Stat5b Map2k1 Raf1 Epo Jak2 Stat3 Irs2 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260410%WP302%RATTUS NORVEGICUS Proteasome degradation Psmd12 Psmd13 Psmd4 Psmb5 Psma5 Rpn2 Psma2 Rpn1 Psmc6 Psme2 Psmb9 Psmc5 Psme1 Psmc2 Psmd11 Psmc4 Ube2b Psmc3 Uchl3 Psmb8 Psmd7 Psmb6l1 Psmd6 Psmb4 Psmb7 Psmd3 Psmd8 Uchl1 Psmb1 Psmd2 Psmd5 Psmb2 Ube2d3 Ube2d1 Psma7 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260410%WP227%RATTUS NORVEGICUS Osteoblast signaling Tnfsf11 Slc34a1 Pdgfra Fgf23 Col1a1 Pdgfrb Bglap Pth CFTR ACTIVITY IN THE PLASMA MEMBRANE%WIKIPATHWAYS_20260410%WP1488%RATTUS NORVEGICUS CFTR activity in the plasma membrane Plcz1 Plcb2 Plcb1 Pdzk1 Plcb3 Rack1 Cftr Ezr Ppp2ca Prkaca Prkcg Nherf2 Nherf1 Prkaa2 Snap23 LIPID DROPLET METABOLISM%WIKIPATHWAYS_20260410%WP3901%RATTUS NORVEGICUS Lipid droplet metabolism Lpin3 Aup1 Acsl1 Gpat2 Gpd2 Lpin1 Plin2 Bscl2 Dgat2 Acsl3 Agpat5 Soat1 Dgat1 Agpat3 Fitm2 Agpat4 Agpat1 Agpat2 Lipa Pnpla2 PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260410%WP282%RATTUS NORVEGICUS Pentose phosphate pathway Rpe Taldo1 Rpia G6pd Kif1b Pgd Pgls Tkt CATECHOLAMINE SYNTHESIS%WIKIPATHWAYS_20260410%WP513%RATTUS NORVEGICUS Catecholamine synthesis Th Pah Ddc Dbh Pnmt STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260410%WP316%RATTUS NORVEGICUS Striated muscle contraction Acta2 Tnnt3 Tnnt2 Tnnt1 Tnnc2 Tnnc1 Tmod1 Tpm4 Tpm3 Tpm2 Neb Tnni3 Tnni2 Tnni1 Myh3 Actn2 Actn3 Mybpc3 Myh8 Actn4 Vim Myl2 Myl9 Myh6 Acta1 Actc1 Actg1 TNF ALPHA AND MUCUS PRODUCTION IN LUNG EPYTHELIUM%WIKIPATHWAYS_20260410%WP1487%RATTUS NORVEGICUS TNF alpha and mucus production in lung epythelium Ikbkb Ripk2 Sos1 Shc1 Muc2 Tlr4 Mapk1 Nfkbia Chuk Egfr Il6 Tgfa Grb2 Ikbkg Map2k1 Rps6ka2 Raf1 Tnfrsf1a Tradd Nfkb1 Traf2 Tnf Rela TRANSLATION FACTORS%WIKIPATHWAYS_20260410%WP149%RATTUS NORVEGICUS Translation factors Eif2s2 Eef2k Eif2ak3 Eif2b1 Eif4h Paip1 Eif1 Eif1ax Eif6 Eif4a2 Eif4e Eif4a1 Etf1 Gspt2 Cluh Eif2ak2 Eif3b Eef1a2 Eef1d Eif3j Pycr3 Eif2s3 Eif2ak1 Eef1g Eif4ebp2 Eif3f Eif4g1 Eif4g3 Eif3a Eif1a Eif4ebp1 Eif5b Eif5a Eif2b3 Eif2b2 Eif2b5 Eif2b4 Kcnq2 MONOAMINE GPCRS%WIKIPATHWAYS_20260410%WP276%RATTUS NORVEGICUS Monoamine GPCRs Htr5a Htr5b Htr1d Htr1f Chrm1 Hrh1 Chrm3 Chrm2 Chrm5 Adra2a Chrm4 Hrh2 Adra2c Adra2b Drd3 Htr4 Drd5 Htr6 Htr7 Drd1 Drd4 Adrb1 Adra1b Adrb3 Adra1d Adra1a Htr2a Htr2c Htr1a AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260410%WP1287%RATTUS NORVEGICUS Amino acid conjugation of benzoic acid Acss2 Glyat S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260410%WP1312%RATTUS NORVEGICUS S1P receptor signal transduction Mapk3 Plcb2 Plcb1 S1pr1 Mapk12 S1pr3 Plcb3 Mapk1 Smpd2 Akt3 Asah1 Sphk2 Akt1 Sphk1 Gnai1 Gnai3 Mapk4 Pik3c2b Akt2 SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260410%WP349%RATTUS NORVEGICUS Synthesis and degradation of ketone bodies Hmgcl Bdh1 Oxct1 Hmgcs2 EBV LMP1 SIGNALING%WIKIPATHWAYS_20260410%WP1278%RATTUS NORVEGICUS EBV LMP1 signaling Nfkb2 Ikbkb Ifnb1 Map3k14 Mapk1 Chuk Traf6 Pdlim7 Tradd Ccl5 Nfkb1 Mapk8 Rela Map3k7 ACETATE MEDIATED PROMOTION OF METABOLIC SYNDROME%WIKIPATHWAYS_20260410%WP3650%RATTUS NORVEGICUS Acetate mediated promotion of metabolic syndrome Ins2 Gast MISMATCH REPAIR%WIKIPATHWAYS_20260410%WP1295%RATTUS NORVEGICUS Mismatch repair Pcna Lig1 Msh2 Pold1 Rfc1 G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260410%WP73%RATTUS NORVEGICUS G protein signaling pathways Rhoa Gng12 Gng13 Itpr1 Plcb3 Adcy3 Prkcg Adcy4 Prkcb Gnai1 Gnai3 Adcy2 Adcy7 Adcy5 Adcy9 Pde4b Prkacb Pde7b Pde7a Prkar1a Akap7 Prkar1b Akap3 Akap4 Arhgef1 Akap1 Gnaz Gng3 Adcy1 Akap10 Akap11 Akap12 Adcy8 Akap9 Akap13 Pde8a Pde8b Kcnj3 Prkaca Pakap Pde4d Gna14 Gng8 Gnao1 Gnal Prkar2b Gng5 Prkce Pde4c Gnas Ppp3cc Ppp3ca Pde1c Pde1a Rras Gng11 Prkd3 Nras Slc9a1 Hras Akap8 Prkcq Gna12 Gna13 Prkci Prkcz Prkcd Gnaq Prkca Gngt1 Gnb2 Gnb1 Gnb3 IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP319%RATTUS NORVEGICUS IL 3 signaling pathway Mapk3 Rac2 Slc2a1 Ywhaq Ppp2ca Gab1 Ywhab Gsk3b Prkcb Birc5 Tnfrsf1b Bcl2l11 Nfkb1 Id1 Bax Lck Mapk14 Hspb1 Pik3cd Rapgef1 Cdc42 Prkaca Matk Crkl Csf2rb Jak2 Kcnip3 Fcer2 Bcl2l1 Dnm1 Hck Gata2 Mapk7 Il3ra Selp Rxra Il3 Pik3r1 Foxo1 Vcl Crk Syk Sos1 Pik3r2 Gsk3a Ptpn6 Ptpn11 Pik3ca Pak1 Fyn Rap1a Lyn Ptk2 Stat5a Atf2 Stat5b Map2k1 Mmp2 Tec Fes Stat3 Gab2 Hras Mmp9 Socs3 Spi1 Rara Bmx Rack1 Mapkapk2 Chek1 Bad Shc1 Src Pxn Mapk1 Jak1 Akt1 Rps6kb2 Grb2 Rac1 Prkca Raf1 Mapk9 Mapk8 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260410%WP469%RATTUS NORVEGICUS Glutathione metabolism Ggt5 Gpx2 Ggt1 Oplah Gclm G6pd Gstm5l Gstt2 Gstt1 Gstm6 Gstm3 Gstm2 Gss Gpx3 Anpep Gsr POLYOL PATHWAY%WIKIPATHWAYS_20260410%WP1303%RATTUS NORVEGICUS Polyol pathway Akr1b1 Sord Aldob Khk RENIN ANGIOTENSIN SYSTEM%WIKIPATHWAYS_20260410%WP376%RATTUS NORVEGICUS Renin angiotensin system Agt Ikbkb Mapk3 Itpr3 Itpr1 Agtr2 Fos Ikbkg Ptgir Map2k7 Rela Plcb1 Mapk13 Map2k4 Pak3 Mas1 Prkaca Pak4 Jak2 Jun Mapk10 Ctsg Cpa3 Mme Ace2 Enpep Ctsa Nln Cma1 Pik3ca Ptk2b Lnpep Itpr2 Pak1 Ptk2 Atf2 Elk1 Stat3 Agtr1a Prkcq Map3k1 Shc1 Pak6 Pak2 Mapk1 Pak5 Grb2 Rac1 Raf1 Mapk9 Anpep Mapk8 Ace Ren SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260410%WP1293%RATTUS NORVEGICUS Selenium metabolism selenoproteins Gpx2 Selenok Fos Selenbp1 Eefsec Crem Sp3 Selenof Sars2 Selenoi Sars1 Fabp1 Selenoo Selenos Nfkb1 Dio1 Selenot Dio2 Dio3 Selenov Rela Sephs1 Msrb1 Trnau1ap Selenow Txnrd2 Nfe2l2 Rpl30 Jun Selenop Gpx3 Gpx6 SPINAL CORD INJURY%WIKIPATHWAYS_20260410%WP2433%RATTUS NORVEGICUS Spinal cord injury C5 Mapk3 Ngfr Gdnf Ccl2 Bdnf Tacr1 Pla2g5 Mbp Cd47 Cxcl1 Sox9 Cxcl2 Pla2g6 Fcgr2a Ptpra Ncan Acan Xylt1 Fos Nox4 Rb1 E2f5 Nos1 Casp3 Gadd45a Necab3 Il2 Il4 E2f1 Tp53 Grin1 Col4a1 Rock2 Ppp3ca Anxa1 Ccnd1 Selp Il1a Cdk1 Il1r1 Tgfb1 Gja1 Mmp9 Btg2 Chst11 Fkbp1a Ptprz1 Cxcl10 Slit1 Slit2 Aqp4 Ccng1 Vim Slit3 Ifng Pdyn Rhoc Rgma Tlr4 Vcan Mapk1 Sema6a Lilrb2 Tnfsf13b Il6 Nos2 Zfp36 Gap43 Arg1 Prpg2 Egr1 Omg Plxna2 Prkca Epha4 Il1b Mag Rtn4r Pla2g2a Ntn1 Klk8 Rtn4 Gfap Bcan Tnfsf13 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP358%RATTUS NORVEGICUS MAPK signaling pathway Mapk3 Ntrk2 Bdnf Cacng8 Cacna1g Cacna1h Cacna1e Prkcg Cacng7 Ikbkg Cacna1f Cacna1c Cacna1d Cacna1a Cacna1b Cacng1 Tnfrsf1a Cacng4 Nfkb1 Cacng5 Cacng3 Cacna1s Map3k20 Rela Cdc25b Lamtor3 Rasgrp3 Stmn1 Rasgrp4 Rasgrp1 Flnc Nlk Map2k6 Rasgrp2 Map3k4 Flnb Hspb1 Stk4 Rras2 Tgfb3 Nf1 Ppp3cb Rasgrf2 Cdc42 Ppp5c Egf Pla2g4b Pla2g4e Arrb2 Pla2g4d Chuk Akt3 Tmem97 Faslg Nfatc1 Nfatc3 Cacna2d1 Arrb1 Cacna2d3 Cacna2d4 Dusp16 Ptpn7 Ptpn5 Jun Dusp3 Rras Ntf4 Fgf2 Dusp2 Mapk10 Fgf1 Hspa1l Fgf4 Dusp4 Fgf3 Ntf3 Fgf6 Dusp10 Fgf5 Dusp9 Fgf8 Dusp8 Fgf7 Cacnb4 Fgf9 Flna Cacnb1 Cacnb2 Taok2 Jund Taok1 Taok3 Mapk8ip1 Ntrk1 Mef2c Pdgfrb Rapgef2 Pdgfa Il1a Mapk8ip3 Il1r2 Fgfr3 Il1r1 Fgfr4 Pak1 Fgfr1 Fgfr2 Rap1a Tab2 Map3k8 Elk1 Cd14 Map3k6 Fgf16 Map3k5 Fgf17 Fgf14 Traf6 Fgf18 Fgf19 Braf Fgf12 Fgf13 Fgf10 Akt2 Fgf11 Nfkb2 Fgf20 Map3k2 Gna12 Map3k1 Pak2 Map4k4 Map4k3 Mos Map4k2 Map4k1 Gng12 Ikbkb Fos Rps6ka3 Rps6ka4 Casp3 Elk4 Sos2 Gadd45a Map2k7 Prkacb Tp53 Ngf Mapk13 Mapk14 Map2k4 Map3k11 Map3k13 Map3k14 Prkaca Crkl Ppp3cc Ppp3ca Crk Sos1 Nras Rasa1 Egfr Tgfb1 Tgfb2 Atf2 Map2k1 Pla2g4a Mapt Traf2 Hras Mapkapk5 Mknk1 Tgfbr1 Daxx Mapkapk2 Mapk1 Akt1 Grb2 Prkcd Rac1 Prkca Raf1 Il1b Mapk9 Mapk8 Fas Map3k7 IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP8%RATTUS NORVEGICUS IL 9 signaling pathway Il2rg Mapk3 Socs3 Jak3 Pik3r1 Shc1 Kat5 Il9 Ptpn11 Mapk1 Il9r Vcp Jak1 Akt1 Grb2 Stat5a Stat5b Map2k1 Stat3 Irs2 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260410%WP124%RATTUS NORVEGICUS Irinotecan pathway Ces1e Abcc2 Ces1d Ces2c Abcg2 Abcc1 Bche Ces1f TOLL LIKE RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP1309%RATTUS NORVEGICUS Toll like receptor signaling pathway Ikbkb Mapk3 Fos Ikbkg Cd86 Cd40 Cd80 Nfkb1 Ccl5 Map2k7 Rela Irf3 Irf7 Irf5 Map2k6 Mapk13 Fadd Mapk14 Map2k4 Pik3cd Nfkbia Chuk Akt3 Jun Mapk10 Pik3r1 Pik3r2 Pik3ca Pik3cg Tab2 Il12b Map3k8 Il12a Cd14 Ticam2 Map2k1 Lbp Traf6 Ly96 Tlr1 Ifna4 Ikbke Ifna1 Ripk1 Tlr8 Tnf Tlr7 Tlr6 Akt2 Tlr5 Nfkb2 Tlr3 Spp1 Tlr2 Cxcl11 Ifnar1 Ccl4 Cxcl10 Ccl3 Tollip Cxcl9 Map2k3 Ifnb1 Pik3r5 Tlr4 Mapk1 Il6 Akt1 Rac1 Il1b Pik3r3 Mapk9 Mapk8 Map3k7 WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260410%WP1288%RATTUS NORVEGICUS Wnt signaling pathway and pluripotency Rhoa Ctbp1 Wnt5a Ctbp2 Ppp2ca Plau Gsk3b Prkcb Axin1 Axin2 Lef1 Tp53 Lrp6 Nlk Lrp5 Wnt3a Dvl1 Dvl2 Tmem97 Dvl3 Wnt7a Prkce Wnt2b Wnt2 Wnt4 Wnt3 Jun Fzd2 Mapk10 Ccnd1 Fzd4 Fzd9 Fzd8 Apc Ppp2r3a Ppp2r2c Ppp2r2b Ppp2cb Fosl1 Crebbp Ptpa Prkcq Ppp2r2a Pafah1b1 Ppp2r1a Sox2 Wnt5b Wnt9b Ppard Wnt16 Fbxw2 Wnt11 Tcf7 Nkd2 Prkci Wnt6 Tcf7l1 Prkcz Cd44 Prkcd Pou5f1 Fzd3 Prkca Ccnd2 Nanog Ppm1j Mapk9 Ctnnb1 Map3k7 GLYCOGEN METABOLISM%WIKIPATHWAYS_20260410%WP160%RATTUS NORVEGICUS Glycogen metabolism Gys2 Agl Pygm Ugp2 Pgm1 Gsk3a Ppp2ca Gsk3b Ppp2r3a Ppp2r2c Ppp2r2b Ppp2cb Ptpa Ppp2r5b Ppp2r5a Gyg1 Ppp2r2a Ppp2r1a Gbe1 Phkb Calm2 Phka1 Phka2 Pygb Phkg1 Gys1 Phkg2 NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP1294%RATTUS NORVEGICUS Nod like receptor NLR signaling pathway Ikbkb Ikbkg Cd40 Ephb2 Mapk8 Chuk Rela Map3k7 INTERACTIONS BETWEEN CFTR AND OTHER ION CHANNELS%WIKIPATHWAYS_20260410%WP1485%RATTUS NORVEGICUS Interactions between CFTR and other ion channels Scnn1b Scnn1g Cftr Nherf1 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260410%WP74%RATTUS NORVEGICUS Integrin mediated cell adhesion Pdpk1 Itgax Ilk Rac2 Itgav Itgae Itgal Vav3 Itgad Itgb8 Itgb6 Itga2b Itgb4 Itgb5 Tln1 Vasp Itga8 Itga6 Itga9 Itga3 Itga4 Itga2 Itga10 Capn9 Git2 Rho Cav3 Capn5 Arhgef7 Cav2 Capn7 Capn1 Capn2 Zyx Mapk12 Capns1 Map2k6 Pak3 Map2k2 Rapgef1 Cdc42 Capn6 Akt3 Pak4 Rock2 Rock1 Mapk10 Vav2 Mapk7 Itgam Vcl Crk Sos1 Pik3r2 Itgb2 Cav1 Capn3 Dock1 Pak1 Fyn Itga1 Rap1a Rap1b Ptk2 Itgb1 Map2k1 Mapk4 Hras Braf Itgb3 Akt2 Map2k3 Mylk2 Shc3 Bcar1 Shc1 Pak6 Src Pxn Pak2 Mapk1 Akt1 Grb2 Rac1 Raf1 Selenop ADIPOGENESIS%WIKIPATHWAYS_20260410%WP155%RATTUS NORVEGICUS Adipogenesis Nr3c1 Ptgis Nr2f1 Celf1 Pck1 Dvl1 Ins2 Lpin3 Lpin1 Plin2 Mef2c Bscl2 Ncor2 Agpat2 Trib3 Wnt5b Il6 Serpine1 Cfd Lipe Agt Slc2a4 Lpl Rb1 Scd Gadd45a Necab3 Id3 E2f1 Igf1 Cdkn1a Nampt Nrip1 Rbl2 Ahr Bmp2 Lifr Rbl1 Prlr Foxc2 Cebpb Twist1 Ebf1 Srebf1 Socs1 Mif Retn Lmna Mbnl1 Frzb Cntfr Gata3 Gata4 Gh1 Hif1a Gtf3a Ndn Cyp26b1 Cisd1 Pck2 Egr2 Irs2 Lif Bmp4 Bmp3 Gata2 Wwtr1 Bmp1 Hmga1 Rxra Plin1 Adipoq Epas1 Sfrp4 Foxo1 Klf15 Rxrg Ncor1 Ucp1 Gadd45b Pnpla3 Cebpd Ncoa2 Zmpste24 Asip Osm Dlk1 Mixl1 Mef2a Mef2b Tgfb1 Klf6 Klf5 Stat5a Lep Stat5b Spock1 Gdf10 Mef2d Stat3 Tnf Il6st Ncoa1 Socs3 Rara Nr1h3 Hnf1a Ppard Ppara Pparg Cyp26a1 Ppargc1a Fas P53 SIGNAL PATHWAY%WIKIPATHWAYS_20260410%WP656%RATTUS NORVEGICUS p53 signal pathway Igf1 Tp53 Rprm Igfbp3 Casp9 Bid Cdk1 Perp Siah1 Ccne1 Mdm2 Casp3 Ccnb3 Gadd45g Gtse1 Bbc3 Parp1 Pmaip1 Fas Bax ESTROGEN SIGNALING%WIKIPATHWAYS_20260410%WP1279%RATTUS NORVEGICUS Estrogen signaling Ikbkb Ilk Cdk7 Tbp Fos Esr1 Nfkb1 Brca1 Mapk14 Prkaca Chuk Jun Ccnd1 Sos1 Hdac1 Elk1 Map2k1 Crebbp Hras Braf Hdac3 Hdac2 Hdac5 Taf13 Taf12 Gtf2f2 Gtf2b Gtf2e1 Polr2c Polr2a Polr2b Gper1 Taf9 Polr2g Polr2h Shc2 Polr2f Polr2i Src Polr2j Gtf2h2 Mapk1 Gtf2h1 Gtf2h4 Gtf2h3 Ercc2 Akt1 Ercc3 Taf7 Grb2 Taf6 Taf5 Mnat1 Gngt1 Mapk9 Ccnh Gnb1 IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP355%RATTUS NORVEGICUS IL 1 signaling pathway Mapk3 Sqstm1 Il1a Il1r2 Ptpn11 Il1r1 Map2k1 Traf6 Nfkb1 Rela Capn1 Capns1 Tollip Nfkbib Map3k14 Mapk1 Nfkbia Plcg1 Chuk Akt1 Prkcz Il1rap Elp1 Peli1 Il1b Irak4 Irak3 Irak2 Sirpa Mapk8 Tab1 Il1rn Map3k7 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260410%WP632%RATTUS NORVEGICUS Cholesterol metabolism Rusc1 Apoc2 Fdft1 Lss Hmgcs1 Mvd Msmo1 Scarb1 Apoc1 Srebf1 Soat1 Hmgcr Lpl Apoe Fdps Dhcr7 Idi1 Mvk TCA CYCLE%WIKIPATHWAYS_20260410%WP347%RATTUS NORVEGICUS TCA cycle Pc Ogdh Pdk4 Fh Sdhc Pdk3 Sdhb Sdha Pdk2 Idh3b Pdhb Afdn Suclg1 Suclg2 Dld Pdha1 Mdh1 Mdh2 FOCAL ADHESION%WIKIPATHWAYS_20260410%WP188%RATTUS NORVEGICUS Focal adhesion Comp Ppp1r12a Tnn Gsk3b Tnr Arhgap5 Reln Col1a2 Lama2 Lama3 Lama4 Thbs4 Blk Srms Txk Chad Pdgfb Erbb2 Lama5 Tesk2 Vtn Tnk1 Col11a1 Ptk6 Col4a6 Tnc Ibsp Pelo Map2k6 Lamc1 Pdgfra Actn1 Lamb1 Thbs1 Col11a2 Lamb3 Pak3 Vegfd Col6a2 Col1a1 Pik3cd Lamc3 Styk1 Vwf Cdc42 Pip5k1c Egf Col4a1 Diaph1 Tnk2 Akt3 Col5a1 Col4a2 Pak4 Thbs2 Rock2 Rock1 Jun Ccnd1 Itgam Vcl Pdgfrb Itgb2 Pdgfa Cav1 Dock1 Pak1 Rap1a Mylk Rap1b Hgf Ptk2 Elk1 Itgb1 Met Mapk4 Braf Akt2 Actb Map2k3 Mylk2 Shc3 Bcar1 Pak6 Pak2 Pak5 Ccnd2 Actg1 Igf1r Pdpk1 Itgax Ilk Rac2 Itgav Itgae Itgal Itgad Itgb8 Itgb6 Itga2b Itgb5 Tln1 Vasp Itga8 Itga6 Itga9 Itga3 Itga4 Flt1 Itga10 Kdr Cav3 Cav2 Capn1 Igf1 Zyx Mapk12 Mapk14 Pten Map2k2 Rapgef1 Fgr Hck Mapk7 Pik3r1 Crk Sos1 Pik3r2 Pik3ca Pik3cg Egfr Fyn Map2k1 Hras Itgb3 Spp1 Bad Shc1 Pik3r5 Src Pxn Mapk1 Pgf Akt1 Grb2 Rac1 Raf1 Vegfc Selenop Vegfb Mapk9 Mapk8 METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260410%WP1286%RATTUS NORVEGICUS Metapathway biotransformation Chst10 Chst12 Cyp2u1 Chst13 Cyp4f18 Chst14 Cyp4f17 Sult1e1 Ndst1 Gstm1 Cyp4x1 Ndst3 Cyp1a1 Cyp1b1 Sult4a1 Sult1b1 Hs3st3b1 Gstm7 Gstcd Cyp51 Hs2st1 Tpmt Comt Naa50 Cyp46a1 Nat8 Nat1 Nat2 Inmt Hnmt Ephx2 Akr1b1 Nat9 Sult6b2 Naa40 Nat10 Hs3st3a1 Chst1 Sult2a1 Chst3 Sult2a6 Chst4 Chst6 Chst9 Naa30 Akr1c1 Zfp628 Gstz1 Hs3st2 Hs3st5 Hs3st6 Cyp2s1 Cyp4f39 Baat Naa20 Akr1d1 Kcnab2 Kcnab3 Cyp2r1 Fmo3 Fmo2 Fmo5 Hs6st3 Fmo4 Hs6st1 Cyp26c1 Gal3st4 Gal3st3 Ugt2b1 Glyat Cyp7a1 Gsto1 Sult2b1 Cyp26b1 Sult1a1 Akr7a3 Akr7a2 Cyp2f2 Gpx2 Gstk1 Cyp7b1 Cyp21a1 Cyp11b2 Cyp17a1 Gstm5 Gstm4 Ephx1 Cyp27b1 Akr1a1 Chst11 Mgst3 Cyp8b1 Mgst1 Gstp1 Cyp24a1 Cyp26a1 Cyp2e1 Fmo1 Akr1b10 Gss Gsr ANGIOTENSIN II SIGNALING ACUTE IN THICK ASCENDING LIMBS%WIKIPATHWAYS_20260410%WP3887%RATTUS NORVEGICUS Angiotensin II signaling acute in thick ascending limbs Itpr3 Pdpk1 Itpr1 Agtr2 Nox4 Itpr2 Prkcg Agtr1a Akt2 Plcg2 Pten Pde2a Agtrap Nos3 Arrb2 Mas1 Plcg1 Prkaca Akt3 Akt1 Gnaq Prkca Calm2 Dnm1 Agtr1b APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260410%WP487%RATTUS NORVEGICUS Apoptosis modulation by HSP70 Hspa1b Fadd Casp9 Map3k1 Bid Aifm1 Casp7 Casp6 Faslg Casp2 Casp3 Cycs Tnfrsf1a Mapk10 Nfkb1 Ripk1 Fas