LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Ace Ren Agt ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Egln3 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc2a1 Nme2 Lalba CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Ikbkb Cd40 Mapk14 Traf3 Traf6 Elp1 Ikbkg Nfkbia Map3k1 Cd40lg Dusp1 Nfkb1 Chuk INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Pik3r4 Plcb4 Itpka Miox Ptpmt1 Inpp4a Pikfyve Ipmk Impa1 Mtor Isyna1 Vac14 Becn1 Sacm1l Inpp1 Pik3cb TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Ace Ren Agt STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Amy1 Ugp2 Ugdh Pgm1 Gpi Gusb Pgm2l1 Gys1 Gaa Agl Pygl LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 L2hgdh D2hgdh GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Gusb Ugt8 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Ptpn7 Cd3g Cd247 Elk1 Map2k7 Cd3d Calm2 Mapk3 Ubc Fyn Rac1 Ppp3ca Nfkbia Jun Map3k1 Ppp3cb Syk Nfkb1 Fos Rela Nfat5 Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Prkcb Plcg1 Prkca Mapk8 Shc1 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Abcc1 Ndufs3 Ndufs2 Ndufs7 Akr1a1 Xdh Cbr3 Akr1c3 Cbr1 Nqo1 Nos3 Abcb1a Abcg2 Ralbp1 Por CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Amt Cps1 Dld Gls2 Glud1 Hal Sds Aqp8 Asns Asrgl1 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Cacna1c Mapk3 Nfkbia Nfkb1 Rela Map2k1 Itpr1 Cacna1f Plcb1 Prkcb Cacna1d Mapk1 Raf1 Prkca Hras CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Gnaq Itpr1 Plcb1 Prkca PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Pik3r4 Inpp5d Erbb2 Synj1 Inpp4b Pik3c2a Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 Plcb1 Pik3cd Pip4k2a Pikfyve Pik3r1 Vac14 Becn1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Mat2a Amd1 Srm Odc1 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Ace Ren Agt MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Ldhd Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Gmppa Pmm1 Mpi Sord Uxs1 Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Cmpk1 Tyms Rrm2b Slc28a3 Rrm2 Slc29a1 Ctps1 Slc28a1 Dck Nme1 Dctd PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Nqo1 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Pdia2 Snta1 Sdf2l1 Kcnj5 Ugt1a6a Kcnj4 Kcnh2 Hyou1 Pdia6 Chrm2 Pdia4 Kcnk1 Kcnq1 Dnajb11 Slc8a1 Cyp1a2 Adrb1 Ugt1a9 Erp29 Atp1b1 Ugt1a5 Cacnb1 Atp1b3 Ugt1a1 Comt Atp1b2 Hspa5 Kcna5 Ephx1 Tpm2 Prkaca Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Cyp2e1 Kcnj11 Abcc9 Cacna2d2 Cyp2c11 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc2a1 Nme2 Lalba PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Hsd17b10 Acat1 Hadh Echs1 Acadl Acss3 Acads Acaa2 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Sult1a1 Fmo1 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 Cyp2b2 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Qars1 Rpl18a Rps18l1 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Cyp3a73 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Rdh16 Dhrs9 Bco1 Cyp3a9 Rpe65 Cyp3a18 Cyp26a1 Dgat1 Retsat Lrat Pdia2 Sdf2l1 Hyou1 Aldh1a1 Pdia6 Pdia4 Dnajb11 Cyp2a3 Erp29 Ugt1a1 Hspa5 Cyp2b2 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Abcd1 Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Ace Ren Agt DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Tyr Dct PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Pfkm G6pc1 Gpi Eno1 Pgam2 Aldoa Hk2 Galm Tpi1l2 Pklr FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Gmppa Pmm1 Mpi Sord Uxs1 Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Ace Ren Agt INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Gng12 Gnb1 Ppp1ca Adcy2 Creb1 Gngt1 Fshr Prkacb Cga AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Ddc Th GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Ptpmt1 Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Cyp2d4 Ugt1a9 Slc22a1 Cyp2b2 Ugt2b7 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Npr1 Cry1 Clock Csnk1e Per1 CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Elk1 Calm2 Mapk3 Rac1 Ppp3ca Jun Map3k1 Ppp3cb Syk Fos Nfat5 Map2k1 Lck Grb2 Cd79b Raf1 Lyn Orai1 Blnk Hras Prkcb Plcg1 Prkca Mapk8 Shc1 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Gnaq Gnb1 Plcb1 Chrm1 Htr2c Gngt1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Eprs1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Farsa Farsb Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Ace Ren Agt GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Aldoa Hk2 Galm Pklr Pgk1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Cyp2e1 Sult1a1 Cyp2d4 Abcb1a Abcg2 Sult2a1 Abcc4 Abcc1 Abcc5 Gstp1 Ugt2b35 Gstt1 Pdia2 Sdf2l1 Ugt1a6a Hyou1 Pdia6 Pdia4 Dnajb11 Cyp1a2 Ugt1a9 Cyp2a3 Erp29 Ugt1a1 Hspa5 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Dbt Dld Bckdhb Sds Bckdha Pccb METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cyp2d4 Cbr1 Alox12 Prxl2b Cyp2u1 Cyp2c11 Alox5 Lta4h Ugt1a9 Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Aars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Alox15b Ltc4s Tbxas1 Pla2g2a Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Mt-co1 Cycs Ndufa1 Mt-atp6 Uqcrc1 Atp5f1d Sdhd Atp5f1c Atp5pb Sdhc Sdhb Atp5mc2 Sdha Atp5f1b Atp5f1a Gpd2 Slc25a4 Slc37a4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Ggcx Vkorc1 Nqo1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Cyp1a2 Scn1b 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Btd Hlcs Acacb CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Ace Ren Agt OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Ugp2 G6pc1 B4galt1 Pgm1 Gale Glb1 Lct Gla Galt Gaa Akr1b1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Cyp2e1 Aldh3a1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Ip6k1 Inpp5j Itpka Inpp4a Ipmk Impa1 Isyna1 Inpp4b Itpk1 Ippk Bpnt1 Nudt3 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Hmgcl Oxct1 Acat1 Hadh Echs1 Acads CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Pmvk Acat1 Hmgcr Fdps Mvd Idi1 Hmgcs1 Fdft1 Lss Sqle BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Gpi Pkm Pfkp Tpi1l2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Pld2 Plpp1 Pisd Pcyt1a Pla2g15 Lypla1 Chat Dgka Chka Agpat1 Gpd2 Cdipt Ptpmt1 Pgs1 Gpam Gpd1 Cds1 Crls1 Pla2g2d Ptdss1 Ptdss2 Phospho1 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway Cfp C8a Cfb C3 Cfd C5 C6 C7 C9 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Slc6a4 Cyp2d4 Cyp3a73 Cyp2c11 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Gla Sptlc1 Acer2 Cerk Sptlc2 Degs2 Enpp1 Samd8 B4galt2 Sphk2 Ugcg Ugt8 Sdr16c5 HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Sod3 Sod2 Sod1 Tyrp1 Cat NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Abcc1 Bche Ces2h Ces1d Top1 Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Abcb1a Hspa5 Abcg2 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Ace Ren Agt WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Gapdhs Bpgm Sdhd Sdhc Sdhb Sdha Cs Mdh1 Idh3g Mpc1 Fh Idh1 Idh3a Tktl1 H6pd Aco1 Pfkm Rpia Gpi Taldo1 Pdhx Aldoc Bckdhb Gls Acly Ogdh Pgk2 Slc16a1 Ireb2 Gsr Eno1 Pkm Glud1 Slc2a13 Cad PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Mapk3 Socs1 Irs1 Insr Map2k1 Ptpn6 Ghr Grb2 Plcg1 Mapk1 Stat5a Stat5b Raf1 Ins2 Rps6ka1 Prkca Slc2a4 Sos1 Hras Jak2 Shc1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Scnn1a Ren Scnn1b Scnn1g Ca1 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc14a2 Atp1b1 Atp1b3 Aqp3 Atp1b2 Aqp2 Atp6v1b1 Slc4a1 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd1 Gpd2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3r4 Pik3cd Ptpmt1 Prex1 Vac14 Inpp5f Plce1 Inppl1 Pik3c3 Zfyve16 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Jun Map3k1 Faf1 Arhgdib Map3k7 Pak1 Ripk2 Prkdc Parp1 Cflar Pak2 Lmnb1 Ptpn13 Lmnb2 Casp8 Rb1 Casp7 Casp3 Casp6 Sptan1 Lmna Map2k4 Fas Fadd Faslg Daxx Dffa Dffb Mapk8 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Abcc1 Slco1b2 Abcb1a Abcg2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Agxt Pc Mpc1 Gpt Aars2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Rpia Tpi1l2 Rpe G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Prkca Erbb4 Erbb3 Psen1 Nrg2 Adam17 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Ace Ren Agt FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Slc22a6 Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Ugt2b1 Ugt1a2 Pdia2 Sdf2l1 Slc22a8 Hyou1 Alox12 Pdia6 Prxl2b Pdia4 Cyp2u1 Cyp2c11 Dnajb11 Alox5 Lta4h Ugt1a9 Alox15 Erp29 Cyp4f18 Cyp4f17 Ugt1a1 Ptgds Hspa5 Cyp2j4 Cyp2b2 Ugt2b7 Cyp4f4 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Slc22a6 Slc1a1 Ca1 Slc3a1 Slc38a4 Slc3a2 Slc7a6 Slc7a7 Slc7a5 Slc7a8 Slc7a9 Slc6a20a Slc4a4 Slc9a1 Aqp1 Slc22a2 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Elk1 Mapk3 Jun Fos Map2k1 Ptpn6 Epo Grb2 Plcg1 Epor Stat5a Raf1 Sos1 Hras Jak2 Mapk8 Shc1 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Cyp2d4 Oprm1 Ugt2b7 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Aldob Prps1 Rpia Pgm1 Gpi G6pd Pfkl Tkt Fbp1 Rpe Pgls HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Gad1 Aldh6a1 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd Aldh2 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Chrm3 Abcc8 Cacna2d2 Adcy10 Vamp2 Rab3a Rapgef4 Gnaq Glp1r Gnb1 Camkk1 Itpr3 Plcb1 Cacna1a Prkca Slc2a2 Cacnb1 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Gnb1 Ppp1ca Htr6 Creb1 Gngt1 Prkacb METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Grin1 Cyp3a9 Cyp2d4 Oprm1 Grin2a Cyp2b2 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Ahcy Cbs Mettl6 Mat2a Scly Cth Slc39a8 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Gnb1 Adcy2 Ptgdr Gngt1 Prkacb DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gpi Gbe1 Gys1 Ganab Pgm2 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Rock1 Gnb1 Lpar4 Itpr1 Plcb1 Srf Akt1 Adcy1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Ntpcr Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Pex13 Abcd1 Crot Acsl1 Pex11g Slc25a20 Abcd2 Cpt2 Pex14 Crat CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Hsd17b1 Ugt2b34l1 Cyp19a1 Akr1d1 Cyp17a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Ass1 Gad1 Abat Asl Adsl Nars1 Aspa Ddo Asns Dars1 Cad Asrgl1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Rela Map2k1 Itpr1 Prkcb Plcb1 Mapk1 Raf1 Prkca Mapk3 Hras Nfkbia Nfkb1 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Cyp2e1 Acss1 Aldh2 Ddc Acss2 Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct Aldh1b1 Cat GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Gh1 Mapk3 Irs1 Map2k1 Ptpn6 Ghr Grb2 Plcg1 Mapk1 Stat5a Stat5b Raf1 Ins2 Rps6ka1 Prkca Slc2a4 Hras Jak2 Shc1 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Agxt Pc Mpc1 Gpt Aars2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Ugp2 Ugdh Galk1 Pgm1 Uxs1 Gale Gck Galt PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Pik3cg Pik3r6 Plcb1 Vav1 Plcg1 Prkca Akt1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Npr1 Clock Nmnat1 Nampt Ppargc1a Rora Sirt1 Nqo1 Nmnat2 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Gnb1 Ppp1ca Htr7 Creb1 Gngt1 Prkacb PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Slc22a6 Ugt2b1 Ptgs1 Ptgs2 Ugt1a2 Pdia2 Sdf2l1 Slc22a8 Hyou1 Pdia6 Pdia4 Dnajb11 Cyp2c11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Ugt2b7 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Gpi Eno1 Pgam2 Aldoart2 Pkm Galm Pfkp Tpi1l2 Slc2a1 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d4 Cyp1a2 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Prkar1b Prkar2a Prkar2b Atp1b4 Uqcr11 Mcu Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Prkacb Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Slc9a1 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Cyp1a2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Fmo3 Chrna4 Ugt1a9 Cyp2a3 Ugt1a5 Chrnb2 Cyp2b2 Chrna3 Aox1 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Tmlhe Setd7 Bbox1 Aldh9a1 Shmt1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Txn1 Pde10a Adsl Rac1 Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Abcc4 Atad1 Atic Abcc5 Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Aox1 Hprt1 Prps1l1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Ak2 Nme2 Nme1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Txn1 Pde10a Adsl Rac1 Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Abcc4 Atad1 Atic Abcc5 Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Aox1 Hprt1 Prps1l1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Gclc Got1 Cth Gclm Mpst Ctns Cdo1 Cars1 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Elk1 Mapk3 Jun Map3k1 Fos Map2k1 Grb2 Raf1 Hras Map2k4 Stat6 Egfr Rasa1 Csnk2a1 Jak1 Egf Prkcb Stat3 Plcg1 Stat2 Srf Stat1 Prkca Sos1 Mapk8 Shc1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Gmppa Pmm1 Mpi Sord Uxs1 Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cbs Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Alpl Aox1 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Ugp2 Ugdh Pgm1 Uxs1 Gale Galk2 Galt EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Ace Ren Agt PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Ces1d Tymp Tyms Cda Slc28a1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Enpp1 Acp1 Tyr ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Ugt2b35 Atp1a2 Ugt2b1 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Ugt1a2 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Dnajb11 Ugt1a9 Erp29 Atp1b1 Cacnb1 Grin2a Atp1b3 Ugt1a1 Kcnd2 Atp1b2 Hspa5 Scn1b Chrnb2 Ugt2b7 Pomc MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Hsd17b10 Acat1 Hadh Echs1 Acadl Acss3 Acads Acaa2 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Plpp1 Agpat1 Gnpat Cept1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Sult1a1 Sult2b1 Chst11 Suox Bpnt1 Papss2 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Ace Ren Agt CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Cyp2d4 Cyp2c11 Ugt1a9 Ptgs1 Ptgs2 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Ak2 Nme2 Nme1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Slc5a1 Atp1a2 Atp1a1 Slc2a2 Atp1b1 Atp1a4 Atp1a3 Gck Atp1b3 Fxyd2 Atp1b2 Treh PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Maob Maoa Slc6a4 Cyp3a9 Cyp2d4 Aox1 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Gpt2 Slc25a22 Gpt Slc38a4 Slc1a4 Slc2a2 Slc2a4 Glud1 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Cmpk1 Tyms Rrm2b Slc28a3 Rrm2 Slc29a1 Ctps1 Slc28a1 Dck Nme1 Dctd WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Aldob Sdhd Sdhc Sdhb Pklr Sdha Cs Mdh1 Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Slc2a2 Idh1 Idh3a Dlst Pdhb Pgk1 Idh3b Aco2 Aco1 Dlat Dld Rpia Gpi G6pd Pfkl Taldo1 Slc1a5 Tkt Hk2 Slc16a1 Eno1 Pgam2 Gls2 Pkm Glud1 Pgls ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Tktl2 Pdha2 Slc16a4 Slc1a2 Sdhb Sdha Cs Mdh1 Dhtkd1 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Aldoart2 Idh3a Pdhb Pgk1 Idh3b Aco2 Aco1 Dlat Dld Rpia Gpi G6pd Taldo1 Hk2 Eno1 Gls2 Pkm Glud1 Pfkp HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Sc5d Msmo1 Hsd17b7 Cyp51 Nsdhl Dhcr24 Dhcr7 Lbr Ebp ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Jak1 Stat3 Mapk1 Mtor IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway Bche Ces2h Ces1d Oprm1 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Plcb4 Ptpmt1 Ipmk Impa1 Cct3 Isyna1 Synj1 Vac14 Bpnt2 Becn1 Pik3c3 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Bcl2l1 Elk1 Cycs Mapk3 Rac1 Vav3 Rala Casp9 Pld1 Rhoa Chuk Ralgds Smad3 Map2k1 Smad4 Apaf1 Foxo4 Raf1 Hras Ralbp1 Akt1 Bad PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Gnaq Gnb1 Cyp21a1 Cyp11a1 Cyp11b2 Agtr1a SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Ddc Th ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Abcb1a Abcg2 Egfr NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Gclc Got1 Cth Gclm Mpst Ctns Cdo1 Cars1 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Rock1 Gnb1 Itpr1 Plcb1 Srf Lpar5 Akt1 Adcy1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Aldh1a1 Cyp3a73 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Glp1r Slc10a2 Gpbar1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Pik3cg Pik3r6 Irs1 Insr Map2k1 Grb2 Mapk1 Raf1 Ins2 Slc2a4 Sos1 Hras Irs2 Map2k2 Pdpk1 Foxo1 Mapk8 Akt1 Shc1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Lars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Ip6k1 Ipmk Impa1 Isyna1 Synj1 Bpnt2 Ppip5k1 Nudt3 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Pex13 Abcd1 Crot Acsl1 Pex11g Slc25a20 Abcd2 Cpt2 Pex14 Crat ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Plcd4 Pik3r4 Impa1 Synj1 Vac14 Becn1 Pik3c3 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Drd1 Adcy2 Prkacb LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Cyp3a9 Cyp3a73 Ephx1 Cyp2b2 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Ccnb1 Pcna Ccne1 Ccnd1 Gadd45b Cdk4 Cdk2 Bcl2 Cdk1 E2f1 Bax Apaf1 Cdkn1a Rb1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C3 Cfd C5 C1qb C6 C1qa C7 Serping1 C9 C1s C1r C8a Masp2 Cfb C2 C4a C1qc Mbl2 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psma2 Psmc3 Psma1 Ubd Psmd13 Psmb5 Psmb4 Psmb7 Ubc Psmb6 Psmb1 Psmb3 Psmd4 Psmb2 Uba1 Psma7 Psma4 Psmc6 Psmc5 Psma3 Psma6 Psma5 Psmc2 Psmc1 Psmc4 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Elk1 Map2k7 Calm2 Jun Map3k1 Gna11 Pld1 Src Fshb Lhb Map2k1 Gnrh1 Gnrhr Grb2 Mapk1 Hbegf Camk2a Raf1 Adcy5 Cdc42 Egr1 Hras Mmp14 Lrrc7 Mmp2 Actn4 Atf4 Erbb4 Cga Itpr1 Plcb1 Prkcb Prkca Mapk8 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Xdh Cyp2e1 Cyp2c11 Cyp1a2 Cyp2a3 Nat1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Ugt2b7 Pomc HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Gmppb Aldob Pmm1 Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Gpi Eno1 Aldoart2 Pkm Hk2 Pfkp BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Elk1 Vav1 Mapk3 Rac1 Ppp3ca Jun Map3k1 Ppp3cb Syk Fos Map2k1 Grb2 Cd79b Raf1 Lyn Orai1 Blnk Hras Nfatc4 Nfatc3 Nfatc2 Ppp3cc Btk Prkcb Plcg1 Prkca Sos1 Mapk8 Shc1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Rock1 Gnb1 Itpr1 Plcb1 Srf Lpar1 Akt1 Adcy1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Hmgcl Oxct1 Acat1 Bdh1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Ass1 Gad1 Abat Asl Adsl Nars1 Aspa Ddo Asns Dars1 Cad Asrgl1 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Cyp3a73 Top2a PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pisd Pcyt1a Chka Cept1 Pcyt2 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Pik3r4 Cct3 Itpk1 Plcd1 Itpka Ambra1 Miox Ptpmt1 Impa1 Isyna1 Vac14 Becn1 Sacm1l Inpp1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Endog Dffa Top2a Casp7 Casp3 Cad Hmgb2 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Gnb1 Prkar1b Prkar2a Prkar2b Gngt1 Adcy10 Prkacb Prkaca GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Kars1 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Prps1 Rpia Pgm1 Gpi Tktl2 G6pd Taldo1 Aldoart2 Fbp1 Rbks Pfkp Rpe TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Gusb Ugt8 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C3 C5 C1qb C6 C1qa C7 C9 C1s C1r C8a C2 C4a C1qc GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Aldob Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Pkm Galm Tpi1l2 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Pfkfb2 Sord Fbp1 Aldoa CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Gusb Ugt8 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Bst1 Nudt12 Nnmt Nnt Nampt Nmrk1 Qprt Enpp1 Nadsyn1 Nmnat2 Pnp Aox1 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Pfkfb2 Gpi Sord ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Ptgs1 Ptgs2 Top2a Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Abcc3 Erp29 Ugt1a1 Abcb1a Hspa5 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Abcb1a Slc22a1 Bad SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Gnpnat1 Gfpt1 Pgm3 Renbp Nans Cmas Slc17a5 Gne Chit1 Hexa Amdhd2 Uap1 Npl Nanp Nagk DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Wars1 Tdo2 Kynu Cyp1a1 Acmsd Ido1 Aldh2 Ddc Haao Aadat Aanat Tph1 Asmt Kmo Inmt Wars2 Cat LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Ikbkb Slc25a1 Myd88 Traf6 Cd14 Tirap Sdhd Ikbkg Tlr4 Sdhc Nfkbia Acly Sdhb Sdha Mdh1 Cs Nfkb1 Rela Chuk Acaca Me1 Pfkp HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Gng12 Gnb1 Adcy2 Avpr2 Gngt1 Fshr Prkacb COAGULATION%SMPDB%SMP0000586 Coagulation Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Acss2 Cyp2e1 Acss1 Aldh1b1 Aldh2 Cat MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Gars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Ugp2 G6pc1 B4galt1 Pgm1 Gale Glb1 Lct Gla Galt Gaa Akr1b1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Sc5d Msmo1 Hsd17b7 Cyp51 Nsdhl Dhcr24 Dhcr7 Lbr Ebp TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Abcc1 Slco1b2 Abcb1a Abcg2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Nmnat1 Nampt Tp53 Sirt1 Nqo1 Nmnat2 Aifm2 Cd38 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Sdhd Slc7a7 Sdhc Sdhb Sdha Cs Slc38a5 Dhtkd1 Idh3g Pc Suclg1 Me1 Mpc1 Suclg2 Fh Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Dld Got2 Slc1a5 Slc1a4 Acly Slc16a1 Gls2 Glud1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Rpia Tpi1l2 Rpe KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Ren Clcnkb Atp1a2 Slc12a6 Atp1a1 Atp1b1 Atp1a4 Atp1a3 Slc12a1 Atp1b3 Fxyd2 Atp1b2 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Eprs1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Ddc Th SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Mapk3 Crk Nfkbia Gngt1 Cxcl12 Nfkb1 Pxn Gnaq Pik3c2g Gnb1 Ptk2 Map2k1 Bcar1 Cxcr4 Plcg1 Mapk1 Gnai1 Ptk2b Raf1 Hras ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Ace Ren Agt Agtr1a DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Drd1 Grin1 Maob Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Cyp3a9 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Aox1 Maoa Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Aldob Pfkm Fbp2 Aldoc Tpi1l2 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Cyp1a2 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Agxt Pc Mpc1 Gpt Aars2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Traf2 Map2k4 Ikbkb Map2k7 Mapk14 Ikbkg Nfkbia Jun Map3k1 Nfkb1 Chuk Atf1 Casp2 Ripk1 Tank Tnf Map2k6 Map4k2 Map2k3 Mapk8 Tradd Cradd TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Abcd1 Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Pik3r6 Plcb1 Plcg1 Prkca Akt1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Cpt1a Acsl1 Hadh Slc25a20 Hadha Hadhb Echs1 Acadl Cpt2 Acaa2 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Nudt4 Itpka Ip6k2 Inpp4a Ipmk Impa1 Isyna1 Inpp1 Ppip5k1 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Aldob G6pc1 Bpgm Gpi Pank3 Fbp1 Pgm1 Pc Mpc1 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Fmo3 Chrna3 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Aox1 Ugt1a9 Cyp2a3 Atp1b1 Ugt1a5 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Cyp2b2 Pomc HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Uroc1 Hdc Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Ftcd Hal Cndp1 Aldh2 Maoa Aoc1 Aldh3a1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Iars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Got2 Mdh2 Slc25a11 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Bhmt Mat2a Aldh7a1 Shmt1 Chdh Gnmt Slc44a1 Dmgdh Mtr Shmt2 Sardh PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C8a Masp2 C2 C4a Mbl2 C3 C5 C6 C7 C9 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Ces1d Tymp Tyms Cda Slc28a1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Gad1 Aldh6a1 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd Aldh2 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Cyp3a73 Top2a TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Pc Me1 Mpc1 Slc25a11 Acly Pdhb Mdh1 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway P2ry12 Cyp3a73 Cyp2c11 Cyp1a2 Abcb1a Cyp2b2 Pon1 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Adra1a Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Hsd17b10 Mecr Ppt1 Hadha Hadhb Echs1 Acaa2 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Gab2 Map2k7 Mapk14 Fyn Rac1 Vav3 Syk Map2k1 Grb2 Mapk1 Raf1 Lyn Pik3r1 Lat Hras Tnf Map2k6 Map2k2 Map2k3 Akt1 Map2k4 Inpp5d Btk Il13 Pla2g4a Fcer1a Il4 Plcg1 Il5 Kras Prkca Pdk1 Ms4a2 Sos1 Nras Csf2 Lcp2 Mapk8 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Gls2 Glud1 L2hgdh PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Rpia Gpi G6pd Tktl2 Taldo1 Fbp1 Rbks Pgm1 Aldoart2 Pfkp Rpe Prps2 Pgls SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Plcb1 Ikbkb Mapk1 Prkca Mapk3 Ikbkg Creb1 Nos3 Nfkb1 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Btd Hlcs Acacb LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Ass1 Gad1 Abat Asl Adsl Nars1 Aspa Ddo Asns Dars1 Cad Asrgl1 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Gad1 Ggt6 Cdo1 Csad Ado SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Txn1 Pde10a Adsl Rac1 Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Abcc4 Atad1 Atic Abcc5 Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Aox1 Hprt1 Prps1l1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Chaf1a Btg2 Hoxb9 Btg1 Prmt1 Ccnd1 Ngf Fgf1 Tp53 Rb1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Abcc8 Cacna1a Ins2 Slc2a2 Cacna2d2 Cacnb1 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Gucy1a2 Trpv4 Prkg2 Gucy1a1 Trpc7 Trpc4 Adcy10 Kcnq4 Trpc3 Gucy1b1 Kcnq3 Kcnq2 Nos3 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp2d4 Cyp2c11 Cyp1a2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Abcc1 Cmpk1 Pcyt1a Dck Pcyt2 Nme1 Slc22a3 Chpt1 Sult1a1 Abcc3 Abcb1a Slc22a1 Abcg2 Pgk1 Slc22a2 Abcc4 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d4 Abcb1a GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Ugp2 Ugdh Galk1 Pgm1 Uxs1 Gale Gck Galt ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c11 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Ptgs1 Ptgs2 Top2a Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Abcc3 Erp29 Ugt1a1 Abcb1a Hspa5 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Gusb Ugt8 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification As3mt Gsto1 Aqp9 Aqp7 Slc2a4 Slc2a1 Pnp TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Pah Tat Yars1 Farsa Hgd Hpd Got1 Farsb Fah HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Ip6k1 Itpka Impa1 Isyna1 Inpp4b Itpk1 Inpp1 Ppip5k1 Nudt3 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Sars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Rock1 Gnb1 Itpr1 Plcb1 Srf Lpar2 Akt1 Adcy1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway Nr1h4 Slc10a2 Fgf19 Fgfr3 Fgfr4 Fgfr1 Fgfr2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Aldob Gapdhs Bpgm Gpi G6pc3 Eno1 Pkm Galm Pfkp Tpi1l2 Pgk2 Slc2a13 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Snta1 Sntb1 Abcc8 Cacna1a Slc2a2 Cacna2d2 Cacnb1 Gcg Scn5a FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Gmppb Aldob Pmm1 Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Pex13 Abcd1 Crot Acsl1 Pex11g Slc25a20 Abcd2 Cpt2 Pex14 Crat INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Mylk Gnb1 Adcy2 Gngt1 Ptgir Prkacb Myl3 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Ikbkb Mapk14 Myd88 Traf6 Cd14 Tirap Ikbkg Tlr4 Nfkbia Map3k1 Nfkb1 Rela Chuk Map3k7 Ecsit Tollip Map2k4 Irak1 Tlr7 Tab2 Tlr6 Tlr5 Tlr3 Tlr2 Mapk8 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Abcc1 Bche Ces2h Ces1d Top1 Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Abcb1a Hspa5 Abcg2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Pank1 Enpp1 Vnn1 Ppcdc Coasy METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Ace Ren Agt 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Elk1 Ikbkb Map2k7 Nfkbia Jun Map3k1 Nfkb1 Chuk Pak1 Mapk1 Hras Map2k6 Map2k2 Pdpk1 Akt1 Creb1 Gngt1 Atf2 Arhgef7 Prkacb Adora2a Braf Map3k4 Gnb1 Nfkb2 Prkcz Rap1a Pard6a Rapgef3 Rapgef2 Rps6ka1 Mapk11 Mapk8 Bad ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Gnaq Itpr1 Plcb1 Prkca HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Slc46a1 Mthfd1l Mtfmt Ggh Dhfr Mthfd1 Mthfd2 Mthfs Ftcd Mthfr SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Hsd17b10 Mecr Ppt1 Hadha Hadhb Echs1 Acaa2 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Tars1 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Sdhd Sdhc Sdhb Pklr Sdha Cs Mdh1 Dhtkd1 Suclg1 Mpc1 Fh Idh1 Idh3a Dlst Pdhb Pgk1 Idh3b Aco2 Aco1 Dlat Dld Rpia Gpi G6pd Pfkl Taldo1 Tkt Hk2 Gls Slc16a1 Eno1 Pgam2 Pkm Glud1 Slc1a3 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Ugp2 Ugdh Galk1 Pgm1 Uxs1 Gale Gck Galt PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rps24 Rpl14 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Aars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rpl7 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rps6 Rplp2 Rpl24 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rps15 Rpl23 Rpl8 Rpl13a Rpl9 Rpl18a Rpl38l1 Rps18l1 Rps20 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Abcc1 Abcc3 Cdkn1a Tp53 Abcc10 Abcb1a Ralbp1 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Adra1a Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Ace Ren Agt BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Ipmk Prex1 Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Dlat Dld Sdhd Sdhc Sdhb Sdha Mdh1 Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Uroc1 Hdc Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Ftcd Hal Cndp1 Aldh2 Maoa Aoc1 Aldh3a1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Pde4d Cyp3a73 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Hadh Slc25a20 Acadm Hadha Hadhb Echs1 Acaa2 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Sult1a1 Sult2b1 Chst11 Suox Bpnt1 Papss2 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Cyp11b3 Hsd11b1 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Dnajb11 Srd5a1 Hsd17b3 Erp29 Cyp19a1 Akr1c1 Ugt1a1 Akr1d1 Hspa5 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Egln3 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 Dlat Dld Slc25a10 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Flt1 Vegfa NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Ugt2b35 Ugt2b1 Oprm1 Ugt1a2 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Ugt2b7 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Aldob Pfkm Rpia Gpi Fbp2 Taldo1 Rbks Rpe Tktl1 H6pd Prpsap1 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Cyp1a2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pisd Chka Cept1 Pcyt2 Ptdss1 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Yars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Aldob Gapdhs Bpgm Gpi G6pc3 Eno1 Pkm Galm Pfkp Tpi1l2 Pgk2 Slc2a13 LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Pik3r4 Plcd3 Itpk1 Ippk Pik3c3 Fig4 Itpka Ambra1 Miox Ptpmt1 Inpp4a Pikfyve Ipmk Impa1 Isyna1 Vac14 Becn1 Inpp1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2u1 Cyp2d5 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Hsd17b10 Ugt1a2 Acadsb Ivd Cyp2c11 Hadha Cyp2a3 Hadhb Ehhadh Cyp2b2 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Dars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Slc5a1 Atp1a2 Atp1a1 Slc2a2 Atp1b1 Atp1a4 Atp1a3 Lct Atp1b3 Fxyd2 Atp1b2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Ace Ren Agt METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Snta1 Sntb1 Scn5a LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Fgb Fga Col1a1 F10 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Aldh1a1 Cyp2d4 Cyp3a73 Cyp2c11 Ugt1a9 Abcc10 Cyp2b2 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Prkca Erbb4 Erbb3 Psen1 Nrg2 Adam17 Egfr RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Mylk Pcna Rps6kb1 Ccnd1 Rac1 Cap1 Vav3 Ccnd3 Map3k1 Wasf1 Cfl1 Pld1 Ppp1r12b Actb Cdk5 Pak1 Myl2 Limk1 Arfip2 Pdgfra Cdkn1a Ralbp1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cbs Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Aldoa Hk2 Galm Pklr Pgk1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Gusb Ugt8 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Irak1 Ikbkb Fadd Myd88 Traf6 Ubc Ikbkg Tlr4 Nfkbia Map3k1 Nfkb1 Rela Chuk Map3k7 Camkk1 Tnfrsf1b Il1a Ripk1 Tnfrsf1a Il1r1 Tnf Map3k14 Tradd METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Cyp3a9 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Cyp2b2 Pomc BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Atp4a Atp4b Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect Aldob Sdhc Sdhb Cs Mdh1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Slc2a2 Idh1 Idh3a Dlst Pdhb Pgk1 Idh3b Aco2 Aco1 Dld Rpia Gpi G6pd Pfkl Slc1a5 Tkt Pdhx Ogdh Slc16a1 Eno1 Pgam2 Pkm Glud1 Pgls CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Fech Uros Hmox1 Ppox Flvcr2 Blvra Alad Hmbs Ftmt Gusb Cox15 Cpox Urod Ugt2b34l1 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Hsd17b1 Ugt2b34l1 Cyp19a1 Akr1d1 Cyp17a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Bhmt Ahcy Mat2a Aldh7a1 Chdh Mtr BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Btd Hlcs Acacb FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Ace Ren Agt ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Cars1 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Bcl2l1 Gab2 Cbl Crkl Rps6kb1 Myc Mdm2 Cdkn1b Crk Skp2 Grb2 Stat5a Pik3r1 Tp53 Mtor Sos1 Jak2 Bad PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Agxt Pc Mpc1 Gpt Aars2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Ces2h Cyp3a73 Ces1d Ugt1a9 Slco1b2 Impdh1 Abcb1a Abcg2 Impdh2 Ugt2b7 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Cyp3a73 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Rdh16 Dhrs9 Bco1 Cyp3a9 Rpe65 Cyp3a18 Cyp26a1 Dgat1 Retsat Lrat Pdia2 Sdf2l1 Hyou1 Aldh1a1 Pdia6 Pdia4 Dnajb11 Cyp2a3 Erp29 Ugt1a1 Hspa5 Cyp2b2 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Ddc Maoa Aoc1 Hgd Got1 Aldh3a1 Haao Mif Dbh Tyr Fah Comt Dct CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway P2ry12 Cyp3a73 Cyp2c11 Cyp1a2 Abcb1a Cyp2b2 Pon1 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Tpo Tg Cyba Cybb Nox4 Nox3 Duox2 Slc5a5 Duox1 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Aldob Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Pmm2 Fbp1 Tgds Amigo3 Tpi1l2 Akr1b1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Elk1 Ikbkb Map2k7 Nfkbia Jun Map3k1 Nfkb1 Chuk Pak1 Mapk1 Adcy2 Hras Map2k6 Map2k2 Pdpk1 Akt1 Adora2b Creb1 Gngt1 Atf2 Arhgef7 Prkacb Braf Map3k4 Gnb1 Nfkb2 Prkcz Rap1a Pard6a Rapgef3 Rapgef2 Rps6ka1 Mapk11 Mapk8 Bad FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Pfkm G6pc1 Bpgm Gpi Eno1 Pgam2 Slc2a2 Aldoa Hk2 Galm Pklr Pgk1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Sst Abcc8 Cacna1a Slc2a2 Cacna2d2 Cacnb1 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Pik3cg Pik3r6 Rps6kb1 Slc7a5 Tsc2 Eif4ebp1 Tsc1 Eif4e Irs1 Insr Ins2 Mtor Irs2 Akt1 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Hmgcl Oxct1 Acat1 Bdh1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling Hif1a Il1b Sirt3 Nlrp3 P4ha3 Tlr4 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Cyp3a73 Ugt1a9 Ugt2b7 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Oprk1 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Gnb1 Ppp1ca Htr4 Creb1 Gngt1 Prkacb ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Cyp1a1 Pdia2 Sdf2l1 Hyou1 Pdia6 Cyp3a73 Pdia4 Dnajb11 Erp29 Hsd17b1 Ugt1a1 Comt Hspa5 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Elk1 Map2k7 Mapk14 Cacna2d2 Jun Map3k1 Gna11 Pld1 Src Fshb Lhb Map2k1 Cacna1f Gnrh1 Cacna1d Gnrhr Grb2 Mapk1 Hbegf Camk2a Raf1 Egr1 Hras Mmp14 Mmp2 Map2k3 Actn4 Atf4 Adcy1 Cacna1c Cga Egfr Itpr1 Plcb1 Prkcb Map3k2 Prkca Sos1 Cacnb1 Mapk8 Prkaca TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Pik3r4 Cct3 Itpk1 Ippk Bpnt1 Pik3c3 Plcd1 Inpp5j Itpka Ambra1 Miox Ptpmt1 Inpp4a Ipmk Impa1 Isyna1 Vac14 Becn1 Sacm1l VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Cpt1a Acsl1 Acadsb Acadm Echs1 Acat1 Hadha Gcdh Hadhb Acadl Cpt2 Acads Acadvl Acaa2 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Elk1 Ikbkb Mapk14 Myd88 Traf6 Cd14 Tirap Ikbkg Tlr4 Nfkbia Jun Map3k1 Nfkb1 Fos Rela Chuk Map3k7 Map2k6 Map2k3 Ecsit Tollip Map2k4 Irak1 Tlr7 Tab2 Tlr3 Tlr2 Eif2ak2 Ppara Mapk8 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Ptpmt1 Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Ptpn7 Cd3g Cd247 Pik3cg Elk1 Vav1 Cd3d Mapk3 Ubc Fyn Rac1 Ppp3ca Nfkbia Jun Map3k1 Ppp3cb Nfkb1 Fos Rela Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Map2k4 Nfatc4 Nfatc3 Nfatc2 Ppp3cc Prkcb Plcg1 Prkca Zap70 Sos1 Cd3e Mapk8 Shc1 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Abcc5 Ppat Xdh Adk Tpmt Slc29a2 Slc28a3 Slc29a1 Rac1 Impdh1 Aox1 Hprt1 Gmps Abcc4 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacna2d2 Cacnb1 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Dnmt1 Bhmt Cbs Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Nme6 Dhodh Tymp Tyms Cda Rrm2b Upb1 Dpys Gda Ak3 Ctps1 Cmpk2 Upp2 Dpyd Dctd Uckl1 Itpa Rrm2 Cant1 Cad NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Grin1 Itpr1 Xdh Nos1 Prkca Grin2a Ppp3ca Dlg4 Prkacb Aldh2 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Tktl2 Slc16a4 Sdhd Sdhc Sdhb Sdha Cs Mdh1 Dhtkd1 Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Aldoart2 Idh3a Dlst Pdhb Pgk1 Aco1 Dlat Dld Rpia Gpi G6pd Taldo1 Gls Eno1 Pgam2 Pkm Glud1 Pfkp Slc2a1 Pgls TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Alpl Aox1 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Gnpnat1 Gfpt1 Ppat Got2 Gpt Abat Cps1 Gad1 Gss Gsr Aldh5a1 Gclc Gclm Gls2 Glud1 Gmps Qars1 Cad Nagk JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Pik3r4 Inpp5d Erbb2 Synj1 Inpp4b Pik3c2a Pten Pik3c3 Egfr Fig4 Cdipt Ambra1 Plcb1 Pik3cd Pip4k2a Pikfyve Pik3r1 Vac14 Becn1 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cyp2d4 Cyp3a73 Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Cyp2c11 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Gclc Got1 Cth Gclm Mpst Ctns Cdo1 Cars1 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Nr1h4 Slc10a2 Gpbar1 Slco1a4 Abcc4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Pex13 Abcd1 Acsl1 Slc25a20 Phyh Abcd2 Cpt2 Pex14 Crat Aldh2 Hacl1 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease G6pc1 Gpi Fbp1 Aldoa Hk2 Mdh2 Mpc1 Eno1 Pank4 Pck1 Pgam2 Slc25a11 Galm Tpi1l2 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc2a1 Nme2 Lalba ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cacna2d2 Htr1a Cacna1a Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Cacnb1 Grin2a Atp1b3 Kcnd2 Atp1b2 Scn1b Chrnb2 Pomc GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Cyp2c11 Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 Cyp2b2 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Dlat Dld Grhpr Pklr Mdh1 Aldh2 Glo1 Ldhd Acat1 Acss2 Acaca Pc Hagh Me1 Acyp1 Acot12 Pck1 Pdhb Akr1b1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Aldh2 Hsd17b10 Acads Acaa2 Dld Acadsb Hibch Aldh6a1 Acadm Abat Bckdhb Echs1 Bcat1 Auh Bckdha Pccb Aox1 Dbt Hmgcl Acat1 Oxct1 Hmgcs2 Mccc1 Ivd Hibadh Mccc2 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Acer1 Sgpl1 Plpp1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Kdsr Glb1 Sgpp2 Gla Sptlc1 Cerk Sptlc2 Degs2 Sphk2 Ugcg Ugt8 Arsa 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Cyp21a1 Cyp11b3 Hsd3b1 Cyp11a1 Akr1c1 Cyp11b2 Akr1d1 Cyp17a1 Hsd11b1 Hsd11b2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Sars1 Agxt Dld Psph Cth Shmt1 Gamt Sds Aldh2 Amt Gatm Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Dmgdh Shmt2 Sardh GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Pfkm G6pc1 Gpi Eno1 Pgam2 Aldoa Hk2 Galm Tpi1l2 Pklr CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Gnb1 Gngt1 Mc2r Prkacb Pomc GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Gusb Ugt8 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Aldh1a1 Cyp3a73 Cyp2c11 Aldh3a1 Cyp2a3 Cyp2b2 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin1 Calm2 Nos1 Prkca Grin2a Ppp3ca Dlg4 Prkacb AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Hsp90aa1 Arnt Ahr EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Elk1 Map2k7 Mapk3 Erbb4 Jun Map3k1 Fos Rasa1 Csnk2a1 Map2k1 Egf Prkcb Stat3 Grb2 Plcg1 Stat5a Srf Raf1 Prkca Hras Jak2 Mapk8 Shc1 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Lpar6 Rock1 Gnb1 Srf Akt1 Adcy1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Gmppb Aldob Pmm1 Phpt1 Mpi Fcsk Sord Fpgt Gfus Khk Pfkl Pfkfb1 Gmds Fbp1 Aldoa Tpi1l2 Akr1b1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Gusb Ugt8 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Pfkm G6pc1 Gpi Eno1 Pgam2 Aldoa Hk2 Galm Tpi1l2 Pklr PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) Gamt Oat Arg1 Pycr2 Eprs1 Prodh Cps1 Ass1 Gatm Dao Rars2 Slc25a15 Got1 P4ha3 Nos1 Ckb Asl Glud1 Otc BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Cyp7b1 Lipa Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1c1 Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7a1 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp2d4 Cyp1a2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a9 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Aldob Pfkm Fbp2 Aldoc Tpi1l2 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Hars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks Pgm1 Rpe Prps1l1 Pgls DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Slc6a2 Slc6a4 Cyp2d4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Clcnkb Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp1b1 Atp1b3 Atp1b2 Slc22a2 Nr3c2 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Gnb1 Lhcgr Ppp1ca Lhb Adcy2 Creb1 Gngt1 Prkacb Cga LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Slc5a1 Atp1a2 Atp1a1 Slc2a2 Atp1b1 Atp1a4 Atp1a3 Lct Atp1b3 Fxyd2 Atp1b2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency G6pc1 Bpgm Gpi Fbp1 Aldoa Hk2 Pgm1 Pc Pank1 Mdh2 Mpc1 Slc37a4 Eno1 Pck1 Pgam2 Slc2a2 Slc25a11 Galm Tpi1l2 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Plpp1 Lipc Lpl Plpp2 Aldh3a1 Gpam Agpat1 Gpd1 Akr1b1 Gpd2 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Gpi Pkm Pfkp Tpi1l2 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Prps1 Rpia Gpi G6pd Pfkl Taldo1 Tkt Fbp1 Aldoa Rbks SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Ugp2 Gpi Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl Ugdh Pgm1 Gusb Gbe1 Ugt2b34l1 Gys2 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Lpin1 Dgat1 Gpam Agpat1 Gpd1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cbs Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Ace Gnaq Gnb1 Ren Agt Agtr1a CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Gad1 Aldh6a1 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd Aldh2 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugp2 Ugdh Gpi Gusb Ugt2b1 Amy2a3 Hk2 Gck Pgm2l1 Agl Pygl 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Dld Aldh8a1 Acmsd Dlst Dhtkd1 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Wars1 Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Ip6k1 Itpka Inpp4a Ipmk Impa1 Isyna1 Inpp4b Itpk1 Ippk Inpp1 Ppip5k1 Nudt3 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Fgb Fga Col1a1 F10 Serpinc1 F12 Fgg F13a1 Plat Plg Klkb1 F2 F3 F7 F8 F9 Ggcx F13b Vkorc1 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Dld Echs1 Dhtkd1 Acat1 Hadh Slc25a2 Aldh7a1 Gcdh Aadat Pipox Dlst Slc7a2 Aass ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Gnaq Gnb1 Itpr1 Prkcb Plcb1 Hrh1 Nfkb1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Acss3 Mlycd Bckdha Pccb Dbt Acat1 Acaca AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Sts Sult2b1 Srd5a1 Hsd17b3 Ugt2b17 Hsd17b1 Ugt2b34l1 Cyp19a1 Akr1d1 Cyp17a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Aldob Gapdhs Bpgm Gpi G6pc3 Pck2 Fbp2 Mdh2 Mpc1 Eno1 Pank4 Galm Tpi1l2 Slc2a13 Cad KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Atp4a Ren Atp4b Trpv5 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc12a3 Clcnkb Slc8a1 Atp1b1 Atp1b3 Aqp3 Atp1b2 Aqp2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Cps1 Ass1 Got2 Slc25a15 Gpt Slc1a5 Slc1a4 Gls2 Asl Glud1 Otc Arg1 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Kcne2 Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnj4 Kcnh2 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Gab2 Map2k7 Fyn Rac1 Syk Map2k1 Lck Grb2 Mapk1 Raf1 Lyn Pik3r1 Lat Blnk Hras Tnf Map2k2 Akt1 Inpp5d Il13 Fcer1a Il4 Plcg1 Kras Prkca Ms4a2 Nras Csf2 Mapk8 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Ikbkb Sucnr1 Mapk3 Ptgs1 Ikbkg Creb1 Nfkb1 Chuk Plcb1 Mapk1 Prkca Mapk11 Nos3 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Sult1a1 Fmo1 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 Cyp2b2 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Txn1 Pde10a Adsl Gda Impdh1 Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm2 Gmps Gmpr Adss2 Pfas Atad1 Atic Gucy1a2 Ppat Nme6 Ampd1 Xdh Paics Ada Hprt1 Prps1l1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Arhgdib Apaf1 Cycs Parp1 Arhgap5 Casp1 Prf1 Arhgap32 Casp8 Jun Casp9 Casp3 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Aldob Pfkm Fbp2 Aldoc Tpi1l2 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Gpx1 Gss Gsr Gclc Gclm Ggct Ggt6 Gsto2 Casp7 Anpep Oplah ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Alox15b Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2e1 Ephx2 Akr1c3 Ptgs1 Alox12b Ptgs2 Cbr1 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Alox15 Cyp4f18 Cyp4f17 Ptgds Cyp2j4 Cyp2b2 Cyp4f4 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl13 Rpl14 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps3 Rps2 Rps25 Rps26 Rps27 Rps29 Rpl5l1 LOC100360522 Rpl27a Rps21 Rps23 Rpl35a Rpl23a Fau Nars1 Rps14 Rpl4 Rpl3 Rps15a Rps19 Rps17l2 Rpl35 Rpl37 Rpsa Rps10 Rpl39 Rps11 Rps12 Rpl7 Rps20l2 Rpl30 Rpl31 Rpl32 Rpl34 Rps3a Rps7 Rps8 Rps5 Rpl8l1 Rps6 Rplp2 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rpl22 Rps16l1 Rplp0 Rpl23 Rpl13a Rpl18a Rps18l1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Aldob Gapdhs Bpgm Gpi G6pc3 Eno1 Pkm Galm Pfkp Tpi1l2 Pgk2 Slc2a13 INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Gnb1 Ppp1ca Adcy2 Hrh2 Creb1 Gngt1 Prkacb DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Fdps Idi1 Hsd17b7 Nsdhl Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Mvd Msmo1 Cyp51 Acat2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Gnb1 Itpr1 Plcb1 Lpar3 Akt1 Adcy1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Dlat Dld Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pc Suclg1 Mpc1 Suclg2 Fh Idh1 Gls2 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Aco1 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine)