LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Gch1 Akr1b1 Pts TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Ren1 Ace ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Egln3 Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Slc25a10 Idh1 Idh2 Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 Egln2 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Abat Acss1 Acat1 Acaca Dld Acss3 Mlycd Bckdha Aldh6a1 Pccb Dbt Acadm ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway P2ry2 Ptk2b Prkca THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Cant1 Galt Nme2 Slc2a1 Lalba G6pc1 B4galt1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Map3k1 Cd40 Mapk14 Traf3 Dusp1 Cd40lg Elp1 Ikbkg Chuk Ikbkb INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Pikfyve Ipmk Impa1 Mtor Pik3r4 Itpka Miox Vac14 Becn1 Ptpmt1 Sacm1l Inpp4a TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Rpia Prps1 Pfkl G6pdx Taldo1 Tkt Fbp1 Rbks CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Ren1 Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Amy1 Ugdh Pgm1 Gusb Pgm2l1 Gys1 Pygl LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Idh1 Gls2 Idh2 Idh3a D2hgdh Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gusb Ugt8 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Elk1 Map3k1 Cd3d Rela Mapk3 Nfat5 Lck Ubc Grb2 Rasgrp1 Rac1 Lat Hras Prkca Ppp3ca Jun Mapk8 Ppp3cb Shc1 Ptpn7 Cd3g Cd247 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Ndufs2 Ndufs7 Akr1a1 Xdh Abcb1a Abcg2 Cbr3 Akr1c18 Ralbp1 Nqo1 Por Nos3 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugdh Gusb Hk2 Pgm2l1 Pygl RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Gls2 Dld Hal Sds Aqp8 Asrgl1 Amt Cps1 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Rela Mapk3 Prkca Cacna1d Mapk1 Cacna1c Hras Itpr1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Cacnb1 Cacna1a Slc2a2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Prkca Gnaq Itpr1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Uap1 Gfpt1 Pgm3 Renbp Npl Nans Cmas Chit1 Nanp Hexa Gnpnat1 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Inpp5d Erbb2 Pik3c2a Pten Pik3c3 Vac14 Egfr Becn1 Fig4 Ambra1 Pik3cd Pikfyve Pip4k2a Pik3r4 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Pgm1 Rpia Rpe Pgls Pfkl Prps1l1 G6pdx Taldo1 Tkt Fbp1 Rbks SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Mat2a Amd1 Srm ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Ren1 Ace MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Pmm1 Sord Fbp1 Khk ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Rrm2b Slc28a3 Slc29a1 Ctps1 Dck Nme1 Dctd PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Pdia2 Sdf2l1 Ugt1a6a Pdia4 Dnajb11 Hspa5 Ephx1 Cyp1a2 Nqo1 Cyp2e1 Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Comt Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Cyp2c11 Kcnj11 Abcc9 Ugt1a9 Erp29 Ugt1a5 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Cant1 Galt Nme2 Slc2a1 Lalba G6pc1 B4galt1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Itpa Tymp Cda Dpys Ak3 Nme6 Upp2 Dpyd Uckl1 Rrm2b Cant1 Ctps1 Dctd SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Acadl Acat1 Hadh Acss3 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Sult1a1 Fmo1 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Qars1 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Abcb1a Abcc3 Cdkn1a Tp53 Ralbp1 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Pdia2 Sdf2l1 Pdia4 Dnajb11 Hspa5 Dhrs4 Cyp3a9 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Aldh1a1 Rdh16 Rpe65 Cyp26a1 Dgat1 Retsat Cyp2a3 Dhrs9 Cyp3a73 Erp29 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Abcd2 Aldh3a2 Abcd1 Phyh MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Ren1 Ace DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Itpa Tymp Cda Dpys Ak3 Nme6 Upp2 Dpyd Uckl1 Rrm2b Cant1 Ctps1 Dctd DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Dct Tyr PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Got1 Pah Tat Yars1 Fah Farsa Hpd Farsb NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Rpe Taldo1 Aldob Rbks Fbp2 H6pd Prpsap1 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Pgam2 Pklr Tpi1l2 Hk2 G6pc1 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Pmm1 Sord Fbp1 Khk AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Ren1 Ace INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Adcy2 Creb1 Fshr Prkacb Ppp1ca Gnb1 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Th Ddc GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 Pgs1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Slc22a1 Ugt2b7 Cyp2d4 Ugt1a9 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Npr1 Clock Csnk1e CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Elk1 Map3k1 Mapk3 Nfat5 Lck Lyn Grb2 Orai1 Blnk Rac1 Hras Prkca Ppp3ca Jun Mapk8 Ppp3cb Shc1 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Chrm1 Gnaq Gnb1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl23 Rplp1 Rpl13a Rpl35a Fau Eprs1 Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Farsa Uba52 Rpl26 Farsb Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Ren1 Ace GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Pgam2 Pklr Hk2 Slc2a2 Bpgm Pgk1 G6pc1 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Pdia2 Sdf2l1 Ugt1a6a Pdia4 Dnajb11 Hspa5 Cyp1a2 Abcc4 Abcc5 Cyp2e1 Gstp1 Ugt2b35 Gstt1 Abcb1a Cyp2a3 Sult1a1 Abcg2 Cyp2d4 Ugt1a9 Erp29 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Dld Sds Bckdha Pccb Dbt METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Slc46a1 Mthfd1 Mthfd2 Mthfs Ftcd Mthfr CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Cyp2c11 Alox15b Ptgs2 Cyp2d4 Ugt1a9 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Aars1 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Abcb1a Abcc3 Cdkn1a Tp53 Ralbp1 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Pla2g2a Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Cycs Ndufa1 Atp5f1d Uqcrc1 Atp5pb Atp5mc2 Atp5f1b Atp5f1a Gpd2 Slc25a4 Sdhc Sdhb Sdha VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Ggcx Vkorc1 Nqo1 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Scn1b Cyp1a2 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Btd Hlcs CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Ren1 Ace OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Pgm1 Akr1b1 Galt Glb1 Lct G6pc1 B4galt1 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Aldh3a1 Cyp2e1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Ip6k1 Ipmk Inpp5j Impa1 Itpka Itpk1 Ippk Inpp4a Bpnt1 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Acat1 Hadh Hmgcl Oxct1 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Mvd Acat1 Fdps Idi1 Lss Pmvk BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Tpi1l2 Pfkp GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Prps1 Pfkl G6pdx Taldo1 Tkt Fbp1 Rbks PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Agpat1 Ptpmt1 Pgs1 Gpam Gpd1 Crls1 Cds1 Gpd2 Pla2g2d Ptdss1 Ptdss2 Pisd Phospho1 Pld2 Pcyt1a Pla2g15 Lypla1 Dgka FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C3 C5 C6 C7 Cfb NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Cyp2c11 Cyp2d4 Cyp3a73 Slc6a4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Sphk2 Cerk Ugt8 Sptlc2 Degs2 Samd8 Ugcg HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Gch1 Akr1b1 Pts CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Cat Sod3 Sod2 Sod1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Pdia2 Sdf2l1 Pdia4 Dnajb11 Abcb1a Hspa5 Abcg2 Cyp3a73 Ugt1a9 Erp29 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Ren1 Ace WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Mpc1 Aco1 Slc2a13 Bpgm Pdhx Slc16a1 Aldoc Idh1 Gls Acly Rpia Idh3a Ireb2 Ogdh Pgk2 Taldo1 Sdhc Sdhb Sdha Cs H6pd PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Abcb1a Abcc3 Cdkn1a Tp53 Ralbp1 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Mapk3 Grb2 Hras Prkca Insr Mapk1 Ptpn6 Ghr Shc1 Stat5a Stat5b Slc2a4 Sos1 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Aqp3 Aqp2 Atp6v1b1 Ca1 Slc4a1 Atp1b1 Atp1b3 Scnn1b Atp1b2 Scnn1g Ren1 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd1 Gpd2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Gch1 Akr1b1 Pts 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Pik3r4 Vac14 Pik3c3 Prex1 Ptpmt1 Inppl1 Zfyve16 Pik3cd XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Map3k1 Casp7 Casp3 Faf1 Arhgdib Map3k7 Sptan1 Map2k4 Pak1 Ripk2 Prkdc Jun Parp1 Mapk8 Fas Fadd Faslg Pak2 Dffa Lmnb2 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Slco1b2 Abcb1a Abcg2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Aars2 Pc Mpc1 Gpt Agxt HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Gch1 Akr1b1 Pts GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Tpi1l2 Rpia Rpe G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Ren1 Ace FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Pdia2 Sdf2l1 Pdia4 Tbxas1 Dnajb11 Gpx1 Hspa5 Alox12 Prxl2b Ugt1a2 Alox5 Slc22a8 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 Ugt2b7 Slc22a6 Cyp2c11 Ugt1a9 Erp29 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Ca1 Slc22a2 Slc22a6 Slc4a4 Slc9a1 Slc1a1 Slc3a1 Aqp1 Slc38a4 Slc3a2 Slc7a6 Slc7a5 Slc7a8 Slc7a9 Slc6a20a IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Elk1 Mapk3 Grb2 Jun Mapk8 Ptpn6 Epo Hras Stat5a Shc1 Epor Sos1 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Ugt2b7 Cyp2d4 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Pgm1 Rpia Rpe Prps1 Pgls Pfkl G6pdx Aldob Tkt Fbp1 HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Ggt6 Gsto2 Gclm Gpx1 Casp7 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Abat Gad1 Dpyd Aldh2 Aoc3 Aldh6a1 Dpys PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Chrm3 Prkca Cacnb1 Cacna1a Rab3a Slc2a2 Rapgef4 Gnaq Camkk1 Gnb1 Vamp2 Itpr3 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Htr6 Creb1 Prkacb Ppp1ca Gnb1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Grin2a Cyp2d4 Cyp3a9 Grin1 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Ahcy Mettl6 Mat2a Scly Cth Slc39a8 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Adcy2 Ptgdr Prkacb Gnb1 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gbe1 Ganab Gys1 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Got1 Pah Tat Yars1 Fah Farsa Hpd Farsb FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Akt1 Rock1 Gnb1 Itpr1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Uap1 Gfpt1 Pgm3 Renbp Npl Nans Cmas Chit1 Nanp Hexa Gnpnat1 ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Abcd2 Abcd1 Pex14 Crat Pex13 Crot Pex11g Slc25a20 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Akr1d1 Cyp17a1 Ugt2b34l1 Sts Srd5a1 Hsd17b1 Cyp19a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Asl Abat Ddo Dars1 Gad1 Asrgl1 Adsl Nars1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Rela Mapk3 Prkca Mapk1 Hras Itpr1 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Aoc1 Dct Got1 Haao Mif Tyr Fah Cat Cyp2e1 Acss1 Aldh3a1 Aldh2 Ddc Comt GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Gh1 Mapk3 Prkca Grb2 Mapk1 Ptpn6 Ghr Hras Stat5a Shc1 Stat5b Slc2a4 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Aars2 Pc Mpc1 Gpt Agxt MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Abat Acss1 Acat1 Acaca Dld Acss3 Mlycd Bckdha Aldh6a1 Pccb Dbt Acadm CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Ugdh Pgm1 Galk1 Galt PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Pik3cg Prkca Akt1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Nmnat1 Nampt Npr1 Ppargc1a Sirt1 Clock Rora Nmnat2 Nqo1 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Hmox1 Ppox Flvcr2 Gusb Ugt2b34l1 Hmbs Ftmt Cox15 Fech Cpox EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Htr7 Creb1 Prkacb Ppp1ca Gnb1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Pdia2 Sdf2l1 Pdia4 Dnajb11 Hspa5 Ugt1a2 Slc22a8 Slc22a6 Cyp2c11 Ptgs2 Ugt2b7 Ugt1a9 Erp29 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Pgam2 Aldoart2 Tpi1l2 Pfkp Slc2a1 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Cyp2d4 Cyp1a2 Slc6a2 Slc6a4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Slc9a1 Prkacb Prkar1b Prkar2a Prkar2b Cacna1g Atp1b4 Atp1a2 Uqcr11 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Cyp1a2 Cyp2d4 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cacna1a KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Aox1 Cyp2a3 Chrnb2 Fmo3 Ugt1a9 Ugt1a5 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Shmt1 Tmlhe Setd7 Bbox1 Aldh9a1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Plpp2 Agpat1 Gpam Gpd1 Aldh3a1 Akr1b1 Gpd2 Lipc Lpl ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Aox1 Rac1 Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Adk Aprt Gucy1b1 Slc29a2 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Abcc4 Atad1 Abcc5 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada Slc28a3 Slc29a1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Ak2 Nme2 Nme1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Aox1 Rac1 Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Adk Aprt Gucy1b1 Slc29a2 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Abcc4 Atad1 Abcc5 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada Slc28a3 Slc29a1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Got1 Gclm Mpst Cth Ctns Cdo1 Cars1 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Elk1 Map3k1 Mapk3 Grb2 Egf Stat6 Rasa1 Csnk2a1 Hras Egfr Stat3 Stat2 Map2k4 Prkca Jun Mapk8 Shc1 Sos1 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Slc46a1 Mthfd1 Mthfd2 Mthfs Ftcd Mthfr FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Pmm1 Sord Fbp1 Khk BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Aox1 Alpl NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Ugdh Pgm1 Galt Galk2 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Ren1 Ace PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Ggt6 Gsto2 Gclm Gpx1 Casp7 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Tymp Cda DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Acp1 Tyr ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Pdia2 Sdf2l1 Pdia4 Dnajb11 Hspa5 Ugt1a2 Ugt2b7 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Ugt2b35 Cacna1a Ugt1a9 Erp29 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Acadl Acat1 Hadh Acss3 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Agpat1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Chst11 Suox Papss2 Sult1a1 Bpnt1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Ren1 Ace CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Cyp2c11 Ptgs2 Cyp2d4 Ugt1a9 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Ak2 Nme2 Nme1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Slc5a1 Atp1b1 Atp1a2 Atp1b3 Atp1b2 Atp1a1 Slc2a2 Atp1a4 Atp1a3 Fxyd2 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Aox1 Maob Cyp2d4 Cyp3a9 Slc6a4 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Gpt Slc1a4 Slc2a2 Slc38a4 Slc2a4 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Rrm2b Slc28a3 Slc29a1 Ctps1 Dck Nme1 Dctd WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Aldob Pgam2 Slc16a1 Pklr Pgls Hk2 Slc1a5 Pgk1 Idh1 Gls2 Rpia Idh3a Pfkl Dlst G6pdx Pdhb Taldo1 Sdhc Sdhb Tkt Sdha Slc2a2 Idh3b Cs Dhtkd1 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Uap1 Gfpt1 Pgm3 Renbp Npl Nans Cmas Chit1 Nanp Hexa Gnpnat1 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Aldoart2 Hk2 Slc2a1 Pgk1 Pfkp Idh1 Gls2 Rpia Pdha2 Idh3a Slc16a4 G6pdx Slc1a2 Pdhb Taldo1 Sdhb Sdha Idh3b Cs Dhtkd1 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Uap1 Gfpt1 Pgm3 Renbp Npl Nans Cmas Chit1 Nanp Hexa Gnpnat1 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Msmo1 Hsd17b7 Dhcr24 Dhcr7 Lbr Ebp Sc5d Cyp51a1 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Mtor Mapk1 Stat3 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Ipmk Impa1 Vac14 Bpnt2 Pik3c3 Becn1 Ptpmt1 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Elk1 Rhoa Ralgds Smad3 Mapk3 Smad4 Bad Foxo4 Bcl2l1 Chuk Rac1 Akt1 Hras Ralbp1 Cycs Vav3 Rala Casp9 Pld1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Cyp11a1 Agtr1 Gnaq Cyp21a1 Gnb1 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Pgm1 Rpia Rpe Pgls Pfkl Prps1l1 G6pdx Taldo1 Tkt Fbp1 Rbks CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Th Ddc ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Abcb1a Abcg2 Egfr NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Got1 Gclm Mpst Cth Ctns Cdo1 Cars1 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Lpar5 Akt1 Rock1 Gnb1 Itpr1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Aldh1a1 Cyp2c11 Aldh3a1 Cyp2a3 Cyp3a73 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Pik3cg Irs2 Grb2 Map2k2 Pdpk1 Akt1 Hras Insr Mapk1 Mapk8 Shc1 Slc2a4 Sos1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Ip6k1 Ipmk Impa1 Ppip5k1 Bpnt2 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Abcd2 Abcd1 Pex14 Crat Pex13 Crot Pex11g Slc25a20 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Impa1 Pik3r4 Vac14 Pik3c3 Plcd4 Becn1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Ggt6 Gsto2 Gclm Gpx1 Casp7 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Adcy2 Prkacb Drd1 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Ephx1 Cyp3a73 Cyp3a9 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Bcl2 Cdk1 E2f1 Gadd45b Bax Cdkn1a Pcna Ccne1 Ccnd1 Cdk4 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Ugdh Gusb Hk2 Pgm2l1 Pygl OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C3 C5 C6 C7 C4 Cfb C1qa C1r Masp2 C1qc C2 Mbl2 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psmb6 Psmb1 Psmc1 Psmc4 Psma2 Psmb3 Psma1 Ubc Psmd4 Psmb2 Uba1 Ubd Psma4 Psmc5 Psma3 Psma5 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Plpp2 Agpat1 Gpam Gpd1 Aldh3a1 Akr1b1 Gpd2 Lipc Lpl GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Elk1 Map3k1 Erbb4 Grb2 Egr1 Hras Gna11 Mmp14 Lrrc7 Src Itpr1 Mmp2 Fshb Lhb Gnrhr Hbegf Camk2a Prkca Adcy5 Cdc42 Jun Mapk1 Mapk8 Pld1 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Cyp2c11 Xdh Cyp2a3 Cyp1a2 Nat1 Cyp2e1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Ugt2b7 Cyp2d4 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cacna1a HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Aldob Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Fcsk Pmm1 Fpgt Sord Fbp1 Gfus Khk BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Aldoart2 Pfkp Hk2 Slc2a1 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Elk1 Map3k1 Mapk3 Lyn Grb2 Orai1 Blnk Rac1 Hras Prkca Ppp3ca Jun Mapk8 Ppp3cb Shc1 Btk Nfatc3 Nfatc2 Sos1 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Akt1 Rock1 Gnb1 Lpar1 Itpr1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Bdh1 Acat1 Hmgcl Oxct1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Asl Abat Ddo Dars1 Gad1 Asrgl1 Adsl Nars1 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Cyp3a73 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pcyt2 Pisd Pcyt1a HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Impa1 Plcd1 Pik3r4 Itpka Miox Vac14 Becn1 Itpk1 Ptpmt1 Sacm1l Ambra1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Casp3 Hmgb2 Endog Dffa Casp7 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Prkar1b Prkar2a Prkar2b Prkacb Prkaca Gnb1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl23 Rplp1 Rpl13a Rpl35a Fau Kars1 Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Pgm1 Aldoart2 Pfkp Rpia Rpe Prps1 G6pdx Taldo1 Fbp1 Rbks TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gusb Ugt8 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C3 C5 C6 C7 C4 C1qa C1r C1qc C2 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Pgam2 Tpi1l2 Aldob Slc2a2 Bpgm G6pc1 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Pfkfb2 Sord Fbp1 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Cacnb1 Cacna1a Slc2a2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gusb Ugt8 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Aox1 Pnp Nampt Bst1 Nnmt Nnt Nmrk1 Nmnat2 Qprt Nadsyn1 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Hmox1 Ppox Flvcr2 Gusb Ugt2b34l1 Hmbs Ftmt Cox15 Fech Cpox PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Hmox1 Ppox Flvcr2 Gusb Ugt2b34l1 Hmbs Ftmt Cox15 Fech Cpox ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Pfkfb2 Sord ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Pdia2 Sdf2l1 Pdia4 Ptgs2 Dnajb11 Abcb1a Abcc3 Hspa5 Cyp3a73 Erp29 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Abcb1a Slc22a1 Stat5a Sos1 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Uap1 Gfpt1 Pgm3 Renbp Npl Nans Cmas Chit1 Nanp Hexa Gnpnat1 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Haao Cat Aanat Tph1 Asmt Kmo Wars2 Wars1 Tdo2 Cyp1a1 Aldh2 Acmsd Ido1 Aadat Ddc LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Rela Ikbkg Chuk Acaca Pfkp Acly Slc25a1 Myd88 Me1 Sdhc Cd14 Sdhb Tirap Sdha Tlr4 Cs Ikbkb HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Adcy2 Fshr Prkacb Avpr2 Gnb1 COAGULATION%SMPDB%SMP0000586 Coagulation Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Acss1 Aldh2 Cat Cyp2e1 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Ugdh Gusb Hk2 Pgm2l1 Pygl GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Plpp2 Agpat1 Gpam Gpd1 Aldh3a1 Akr1b1 Gpd2 Lipc Lpl PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rpl23 Gars1 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Pgm1 Akr1b1 Galt Glb1 Lct G6pc1 B4galt1 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Msmo1 Hsd17b7 Dhcr24 Dhcr7 Lbr Ebp Sc5d Cyp51a1 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Got1 Pah Tat Yars1 Fah Farsa Hpd Farsb VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Slco1b2 Abcb1a Abcg2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Gch1 Akr1b1 Pts HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Nmnat1 Nampt Tp53 Sirt1 Nmnat2 Nqo1 Aifm2 Cd38 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Pc Suclg1 Mpc1 Aco2 Dlat Got2 Dld Slc1a5 Slc1a4 Slc16a1 Gls2 Idh2 Acly Idh3a Dlst Pdhb Me1 Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Tpi1l2 Rpia Rpe KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Slc12a1 Ren1 Atp1b1 Atp1a2 Atp1b3 Atp1b2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc12a6 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Slc46a1 Mthfd1 Mthfd2 Mthfs Ftcd Mthfr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl23 Rplp1 Rpl13a Rpl35a Fau Eprs1 Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Th Ddc SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Ugdh Gusb Hk2 Pgm2l1 Pygl ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Cxcr4 Gnai1 Pik3c2g Ptk2 Mapk3 Bcar1 Ptk2b Mapk1 Hras Gnaq Gnb1 Pxn ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Ugdh Gusb Hk2 Pgm2l1 Pygl SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Ren1 Ace Agtr1 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Aox1 Cyp3a9 Cyp2d4 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Maob Cacna1a TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Aldoc Tpi1l2 Aldob Fbp2 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Cyp1a2 Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Aars2 Pc Mpc1 Gpt Agxt TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Map3k1 Mapk14 Atf1 Casp2 Ikbkg Tank Tnf Chuk Map2k6 Map4k2 Map2k3 Tradd Cradd Traf2 Map2k4 Jun Mapk8 Ikbkb TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Abcd2 Aldh3a2 Abcd1 Phyh LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Prkca Akt1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Acadl Hadh Slc25a20 Hadha Hadhb Cpt1a INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Ipmk Impa1 Itpka Ppip5k1 Inpp4a 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Pc Pgm1 Mpc1 Aldob Bpgm Pank3 Pgam2 Slc25a11 Tpi1l2 Slc2a2 Fbp1 Pck1 G6pc1 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Aox1 Atp1a2 Fmo3 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cyp2a3 Cacna1a Ugt1a9 Ugt1a5 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Hmox1 Ppox Flvcr2 Gusb Ugt2b34l1 Hmbs Ftmt Cox15 Fech Cpox GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Carnmt1 Aoc1 Uroc1 Hars1 Aldh3a1 Hdc Cndp2 Aldh2 Hnmt Ftcd Hal PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Mdh2 Slc25a11 Got2 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Itpa Tymp Cda Dpys Ak3 Nme6 Upp2 Dpyd Uckl1 Rrm2b Cant1 Ctps1 Dctd SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Bhmt Mat2a Gnmt Dmgdh Shmt1 Mtr Shmt2 Chdh Sardh Aldh7a1 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C3 C5 C6 C7 C4 Masp2 C2 Mbl2 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Tymp Cda L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rars1 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Abat Gad1 Dpyd Aldh2 Aoc3 Aldh6a1 Dpys TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Cyp3a73 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Pc Mpc1 Slc25a11 Acly Me1 Pdhb CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway Cyp2c11 Abcb1a Cyp1a2 Cyp3a73 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Cacnb1 Cacna1a Slc2a2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Adra1a Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Mecr Ppt1 Hadha Hadhb THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Itpa Tymp Cda Dpys Ak3 Nme6 Upp2 Dpyd Uckl1 Rrm2b Cant1 Ctps1 Dctd FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Inpp5d Grb2 Map2k2 Rac1 Lat Hras Prkca Sos1 Mapk14 Gab2 Lyn Tnf Map2k6 Akt1 Map2k3 Map2k4 Mapk1 Mapk8 Fcer1a Il5 Pdk1 Vav3 Btk Ms4a2 Csf2 Lcp2 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Rpia Rpe Taldo1 Aldob Rbks Fbp2 H6pd Prpsap1 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Idh1 Gls2 Idh2 Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Pgm1 Aldoart2 Pfkp Rpia Rpe Pgls G6pdx Taldo1 Fbp1 Rbks SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Mapk3 Prkca Ikbkg Creb1 Mapk1 Ikbkb Nos3 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Btd Hlcs LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Asl Abat Ddo Dars1 Gad1 Asrgl1 Adsl Nars1 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Ggt6 Ado Gad1 Cdo1 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Aox1 Rac1 Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Adk Aprt Gucy1b1 Slc29a2 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Abcc4 Atad1 Abcc5 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada Slc28a3 Slc29a1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Rpia Prps1 Pfkl G6pdx Taldo1 Tkt Fbp1 Rbks QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Hoxb9 Btg1 Prmt1 Ngf Fgf1 Tp53 Ccnd1 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Cacnb1 Cacna1a Slc2a2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Gucy1a2 Gucy1b1 Gucy1a1 Trpc7 Trpc4 Kcnq4 Trpc3 Prkg2 Kcnq2 Nos3 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp2c11 Cyp2d4 Cyp1a2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Pcyt2 Abcc3 Slc22a2 Pgk1 Slc22a3 Abcc4 Chpt1 Abcb1a Slc22a1 Sult1a1 Abcg2 Dck Nme1 Pcyt1a VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Abcb1a Cyp2d4 Slc6a2 Slc6a4 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Ugdh Pgm1 Galk1 Galt ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c11 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Pdia2 Sdf2l1 Pdia4 Ptgs2 Dnajb11 Abcb1a Abcc3 Hspa5 Cyp3a73 Erp29 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gusb Ugt8 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification Gsto1 Pnp Slc2a1 Slc2a4 As3mt TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Got1 Pah Tat Yars1 Fah Farsa Hpd Farsb HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Hrh1 Gnaq Gnb1 Itpr1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Ip6k1 Impa1 Itpka Ppip5k1 Itpk1 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl23 Rplp1 Rpl13a Rpl35a Fau Sars1 Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Lpar2 Akt1 Rock1 Gnb1 Itpr1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway Nr1h4 Fgf19 Fgfr1 Fgfr2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Tpi1l2 Pfkp Slc2a13 Pgk2 G6pc3 Aldob Bpgm PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Snta1 Gcg Cacnb1 Cacna1a Slc2a2 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Aldob Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Fcsk Pmm1 Fpgt Sord Fbp1 Gfus Khk BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Abcd2 Abcd1 Pex14 Crat Pex13 Crot Pex11g Slc25a20 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Adcy2 Ptgir Myl3 Mylk Prkacb Gnb1 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Map3k1 Mapk14 Rela Ikbkg Chuk Map3k7 Map2k4 Myd88 Cd14 Mapk8 Tlr7 Tirap Tab2 Tlr4 Tlr6 Tlr5 Tlr3 Ikbkb Tlr2 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Pdia2 Sdf2l1 Pdia4 Dnajb11 Abcb1a Hspa5 Abcg2 Cyp3a73 Ugt1a9 Erp29 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Rpia Rpe Taldo1 Aldob Rbks Fbp2 H6pd Prpsap1 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Vnn1 Ppcdc METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Pgm1 Rpia Rpe Pgls Pfkl Prps1l1 G6pdx Taldo1 Tkt Fbp1 Rbks TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Ren1 Ace 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Elk1 Creb1 Map2k2 Pdpk1 Prkacb Hras Ikbkb Map3k1 Atf2 Adora2a Arhgef7 Bad Map3k4 Nfkb2 Prkcz Rap1a Chuk Map2k6 Rapgef3 Akt1 Mapk11 Gnb1 Pak1 Mapk1 Jun Mapk8 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Prkca Gnaq Itpr1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Slc46a1 Mthfd1 Mthfd2 Mthfs Ftcd Mthfr SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Abat Acss1 Acat1 Acaca Dld Acss3 Mlycd Bckdha Aldh6a1 Pccb Dbt Acadm TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Mecr Ppt1 Hadha Hadhb ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Tars1 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Pgam2 Slc16a1 Pklr Gls Hk2 Pgk1 Idh1 Rpia Idh3a Pfkl Dlst G6pdx Pdhb Taldo1 Sdhc Sdhb Tkt Sdha Idh3b Cs Dhtkd1 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Gch1 Akr1b1 Pts NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Ugdh Pgm1 Galk1 Galt PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rpl19 Rpl7 Rpl30 Rps15 Rpl10 Rpl9 Rps3a Rpl38l1 Rps25 Rps26 Rps20 Rps27 Rps24 Rps8 Rpl27a Rps6 Rpl24 Aars1 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Abcb1a Abcc3 Cdkn1a Tp53 Ralbp1 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Adra1a Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Ren1 Ace BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Ipmk Prex1 Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Ugdh Gusb Hk2 Pgm2l1 Pygl AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Pc Suclg1 Mpc1 Aco2 Dlat Dld Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Carnmt1 Aoc1 Uroc1 Hars1 Aldh3a1 Hdc Cndp2 Aldh2 Hnmt Ftcd Hal CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Cyp3a73 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Hadh Slc25a20 Hadha Hadhb Acadm ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Chst11 Suox Papss2 Sult1a1 Bpnt1 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Pdia2 Akr1d1 Sdf2l1 Pdia4 Hsd11b1 Dnajb11 Hspa5 Srd5a1 Erp29 Cyp19a1 Cyp11b3 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Aldh1a1 Gstm2 Cyp2c11 Aldh3a1 Cyp2a3 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Egln3 Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Slc25a10 Idh1 Idh2 Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 Egln2 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Vegfa NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Pdia2 Ugt2b35 Sdf2l1 Pdia4 Dnajb11 Hspa5 Ugt2b7 Ugt1a2 Ugt1a9 Erp29 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Rpia Rpe Taldo1 Aldob Rbks Fbp2 H6pd Prpsap1 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cyp1a2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pcyt2 Ptdss1 Pisd METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Yars1 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Tpi1l2 Pfkp Slc2a13 Pgk2 G6pc3 Aldob Bpgm LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Itpka Miox Pik3c3 Vac14 Becn1 Ptpmt1 Itpk1 Fig4 Ippk Ambra1 Inpp4a Pikfyve Ipmk Impa1 Pik3r4 Plcd3 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2d5 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Acadsb Cyp2c11 Cyp2a3 Ugt1a2 Ehhadh Hadha Hadhb Ivd PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl23 Rplp1 Dars1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Slc5a1 Atp1b1 Atp1a2 Atp1b3 Atp1b2 Atp1a1 Slc2a2 Atp1a4 Lct Atp1a3 Fxyd2 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Ren1 Ace METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Snta1 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Fgb Fga Col1a1 F10 F12 Fgg 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Aldh1a1 Cyp2c11 Cyp2d4 Cyp3a73 Ugt1a9 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Erbb4 Erbb3 Psen1 Nrg2 Prkca Adam17 Egfr RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Map3k1 Limk1 Pdgfra Cdkn1a Rac1 Pcna Ralbp1 Ccnd1 Pak1 Mylk Cap1 Ccnd3 Vav3 Wasf1 Ppp1r12b Cdk5 Pld1 Myl2 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Pgam2 Pklr Hk2 Slc2a2 Bpgm Pgk1 G6pc1 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gusb Ugt8 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Map3k1 Rela Tnfrsf1b Il1a Tnfrsf1a Il1r1 Ubc Camkk2 Ikbkg Map3k14 Tnf Chuk Tradd Map3k7 Myd88 Fadd Tlr4 Camkk1 Ikbkb METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Cyp3a9 Cyp2d4 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cacna1a BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Sstr4 Chrm3 Ca1 Sst Cckbr Hrh2 Gast Clic2 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect Pc Suclg1 Mpc1 Aco2 Aco1 Dld Aldob Pdhx Pgam2 Slc16a1 Pgls Ogdh Slc1a5 Pgk1 Idh1 Rpia Idh3a Pfkl Dlst G6pdx Pdhb Sdhc Sdhb Tkt Slc2a2 Idh3b Cs CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Ggt6 Gsto2 Gclm Gpx1 Casp7 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Hmox1 Ppox Flvcr2 Gusb Ugt2b34l1 Hmbs Ftmt Cox15 Fech Cpox ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Akr1d1 Cyp17a1 Ugt2b34l1 Sts Srd5a1 Hsd17b1 Cyp19a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Ahcy Bhmt Mat2a Mtr Chdh Aldh7a1 BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Btd Hlcs FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Ren1 Ace ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Cars1 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Bad Bcl2l1 Gab2 Cbl Grb2 Tp53 Crkl Mdm2 Cdkn1b Skp2 Mtor Stat5a Sos1 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Aars2 Pc Mpc1 Gpt Agxt CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Slco1b2 Abcb1a Abcg2 Ugt2b7 Cyp3a73 Impdh2 Ugt1a9 Impdh1 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Pdia2 Sdf2l1 Pdia4 Dnajb11 Hspa5 Dhrs4 Cyp3a9 Dhrs3 Aldh1a2 Awat1 Rdh11 Rdh8 Rdh12 Aldh1a1 Rdh16 Rpe65 Cyp26a1 Dgat1 Retsat Cyp2a3 Dhrs9 Cyp3a73 Erp29 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cyp2d4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Aoc1 Dct Got1 Haao Aldh3a1 Mif Tyr Fah Ddc Comt CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway Cyp2c11 Abcb1a Cyp1a2 Cyp3a73 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Cybb Nox4 Nox3 Duox2 Slc5a5 Duox1 Tpo Tg Cyba HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Tpi1l2 Akr1b1 Pfkl Pfkfb1 Fcsk Mpi Fpgt Aldob Sord Fbp1 Gfus Khk INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Elk1 Creb1 Map2k2 Pdpk1 Prkacb Hras Adora2b Ikbkb Map3k1 Atf2 Arhgef7 Bad Map3k4 Nfkb2 Adcy2 Prkcz Rap1a Chuk Map2k6 Rapgef3 Akt1 Mapk11 Gnb1 Pak1 Mapk1 Jun Mapk8 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Pgam2 Pklr Hk2 Slc2a2 Bpgm Pgk1 G6pc1 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Sst Cacnb1 Cacna1a Slc2a2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Slc7a5 Mtor Pik3cg Tsc2 Irs2 Tsc1 Insr Akt1 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Gch1 Akr1b1 Pts SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Bdh1 Acat1 Hmgcl Oxct1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling Sirt3 Nlrp3 Tlr4 P4ha3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Ugt2b7 Cyp3a73 Ugt1a9 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Oprk1 Atp1a1 Atp1a4 Atp1a3 Fxyd2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Creb1 Prkacb Ppp1ca Gnb1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Pdia2 Sdf2l1 Pdia4 Cyp1a1 Dnajb11 Hspa5 Cyp3a73 Hsd17b1 Erp29 Comt MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Elk1 Grb2 Hras Egfr Prkca Cacna1c Map3k2 Sos1 Map3k1 Mapk14 Cacnb1 Egr1 Map2k3 Gna11 Mmp14 Prkaca Lrrc7 Src Itpr1 Mmp2 Fshb Lhb Gnrhr Hbegf Camk2a Cacna1d Mapk1 Jun Mapk8 Pld1 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Plcd1 Itpka Miox Pik3c3 Vac14 Becn1 Ptpmt1 Itpk1 Ippk Sacm1l Ambra1 Inpp4a Bpnt1 Ipmk Inpp5j Impa1 Pik3r4 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Acadl Acadsb Acat1 Hadha Gcdh Hadhb Cpt1a Acadm ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Elk1 Map3k1 Mapk14 Rela Ikbkg Chuk Map2k6 Map2k3 Map3k7 Map2k4 Myd88 Jun Cd14 Mapk8 Tlr7 Tirap Tab2 Tlr4 Eif2ak2 Ppara Tlr3 Ikbkb Tlr2 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 Pgs1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Elk1 Cd3d Rela Mapk3 Pik3cg Lck Ubc Grb2 Rasgrp1 Rac1 Lat Hras Prkca Sos1 Map3k1 Map2k4 Ppp3ca Jun Mapk8 Ppp3cb Shc1 Ptpn7 Nfatc3 Cd3g Nfatc2 Cd247 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Aox1 Adk Slc29a2 Rac1 Gmps Abcc4 Abcc5 Ppat Xdh Hprt1 Slc28a3 Slc29a1 Impdh1 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacnb1 Cacna1c ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway P2ry2 Ptk2b Prkca MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Bhmt Mat2a Cth Amd1 Shmt1 Chdh Msrb3 Mthfr Msrb2 Srm MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Itpa Tymp Cda Dpys Ak3 Nme6 Upp2 Dpyd Uckl1 Rrm2b Cant1 Ctps1 Dctd NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Grin2a Xdh Aldh2 Prkca Ppp3ca Prkacb Grin1 Nos1 Itpr1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Pc Suclg1 Mpc1 Aco1 Dlat Dld Pgam2 Gls Aldoart2 Pgls Slc2a1 Pgk1 Pfkp Idh1 Rpia Idh3a Slc16a4 Dlst G6pdx Pdhb Taldo1 Sdhc Sdhb Sdha Cs Dhtkd1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Aox1 Alpl PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Abat Gfpt1 Ppat Gad1 Gclm Gls2 Got2 Gpt Gmps Qars1 Cps1 Gnpnat1 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Inpp5d Erbb2 Pik3c2a Pten Pik3c3 Vac14 Egfr Becn1 Fig4 Ambra1 Pik3cd Pikfyve Pip4k2a Pik3r4 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Cyp2d4 Cyp3a73 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Chrnb2 Cacnb1 Pomc Atp1b1 Drd1 Atp1b3 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Cyp2c11 Cacna1a APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Got1 Gclm Mpst Cth Ctns Cdo1 Cars1 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Nr1h4 Abcc4 Slco1a4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Abcd2 Abcd1 Pex14 Aldh2 Crat Pex13 Slc25a20 Phyh ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Mdh2 Pgam2 Mpc1 Slc25a11 Tpi1l2 Hk2 Fbp1 Pck1 G6pc1 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Cant1 Galt Nme2 Slc2a1 Lalba G6pc1 B4galt1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Grin2a Adra1a Kcnd2 Scn10a Scn1b Pcsk2 Cacnb1 Chrnb2 Atp1b1 Pomc Atp1b3 Drd1 Atp1b2 Htr1a Grin1 Slc6a2 Slc6a4 Atp1a2 Cacna1a Atp1a1 Atp1a4 Atp1a3 Fxyd2 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Pdia2 Sdf2l1 Cyp2c11 Pdia4 Dnajb11 Hspa5 Ugt1a9 Erp29 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Pc Dlat Dld Acat1 Acaca Pklr Akr1b1 Aldh2 Glo1 Hagh Pdhb Me1 Acyp1 Acot12 Pck1 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Aox1 Acadsb Dld Bckdha Aldh6a1 Pccb Dbt Acadm Abat Acat1 Aldh2 Hmgcl Oxct1 Hmgcs2 Bcat1 Mccc1 Auh Ivd Mccc2 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Sphk2 Cerk Sptlc2 Degs2 Glb1 Ugcg Arsa Acer1 Enpp7 Galc Neu3 B4galt6 Ugt8 Sgms1 Kdsr 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Akr1d1 Hsd3b1 Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Cyp21a1 Cyp11b3 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Gars1 Psat1 Gcat Gnmt Cth Srr Dmgdh Shmt1 Shmt2 Dld Sardh Sars1 Agxt Psph Aldh2 Gamt Sds Gatm Amt GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Pgam2 Pklr Tpi1l2 Hk2 G6pc1 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Pomc Prkacb Gnb1 Mc2r GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gusb Ugt8 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Aldh1a1 Cyp2c11 Aldh3a1 Cyp2a3 Cyp3a73 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Grin2a Prkca Ppp3ca Prkacb Grin1 Nos1 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Arnt Ahr EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Elk1 Map3k1 Erbb4 Mapk3 Grb2 Egf Rasa1 Csnk2a1 Hras Stat3 Prkca Jun Mapk8 Shc1 Stat5a LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Lpar6 Akt1 Rock1 Gnb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Aldob Tpi1l2 Akr1b1 Pfkl Pfkfb1 Mpi Fcsk Pmm1 Fpgt Sord Fbp1 Gfus Khk GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gusb Ugt8 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Pgam2 Pklr Tpi1l2 Hk2 G6pc1 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) Asl Prodh1 Got1 Gamt Arg1 Pycr2 Eprs1 Gatm Dao Rars2 Cps1 P4ha3 Nos1 Ckb BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Akr1d1 Scp2 Slc27a5 Cyp8b1 Cyp7b1 Ch25h Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Ggt6 Gsto2 Gclm Gpx1 Casp7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp2d4 Cyp1a2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a9 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Aldoc Tpi1l2 Aldob Fbp2 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Hars1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Pgm1 Rpia Rpe Pgls Pfkl Prps1l1 G6pdx Taldo1 Tkt Fbp1 Rbks DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Cyp2d4 Slc6a2 Slc6a4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 Slc22a2 Nr3c2 Slc22a6 Atp1b1 Scnn1b Atp1b3 Scnn1g Atp1b2 Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc12a1 Slc7a5 Slc7a8 Slc12a3 Slc7a9 Slc6a20a INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Lhb Lhcgr Adcy2 Creb1 Prkacb Ppp1ca Gnb1 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Slc5a1 Atp1b1 Atp1a2 Atp1b3 Atp1b2 Atp1a1 Slc2a2 Atp1a4 Lct Atp1a3 Fxyd2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency Pc Pgm1 Mpc1 Bpgm Mdh2 Pgam2 Slc25a11 Tpi1l2 Hk2 Slc2a2 Fbp1 Pck1 G6pc1 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Plpp2 Agpat1 Gpam Gpd1 Aldh3a1 Akr1b1 Gpd2 Lipc Lpl ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Tpi1l2 Pfkp PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Rpia Prps1 Pfkl G6pdx Taldo1 Tkt Fbp1 Rbks SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Ugdh Pgm1 Gusb Gys2 Gbe1 Ugt2b34l1 Hk2 Pgm2l1 Pygl TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Agpat1 Gpam Gpd1 Dgat1 Lpin1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Ren1 Ace Agtr1 Gnaq Gnb1 CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Abat Gad1 Dpyd Aldh2 Aoc3 Aldh6a1 Dpys GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugdh Gusb Hk2 Pgm2l1 Pygl 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Aldh8a1 Acmsd Dlst Dld Dhtkd1 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Rpl23 Rplp1 Rpl13a Rpl35a Fau Wars1 Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Rplp0 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Ip6k1 Ipmk Impa1 Itpka Ppip5k1 Itpk1 Ippk Inpp4a ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Klkb1 Plat Plg F7 F9 Ggcx Vkorc1 Serpinc1 Fgb Fga Col1a1 F10 F12 Fgg SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Acat1 Hadh Dlst Dld Aadat Pipox Aldh7a1 Slc7a2 Gcdh Aass Dhtkd1 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Hrh1 Gnaq Gnb1 Itpr1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Abat Acss1 Acat1 Acaca Dld Acss3 Mlycd Bckdha Aldh6a1 Pccb Dbt Acadm AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Akr1d1 Cyp17a1 Ugt2b34l1 Sts Srd5a1 Hsd17b1 Cyp19a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Mdh2 Mpc1 Tpi1l2 Slc2a13 G6pc3 Aldob Bpgm Fbp2 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Aqp3 Aqp2 Trpv5 Atp1b1 Atp1b3 Atp1b2 Slc12a3 Ren1 Atp1a2 Atp1a1 Atp1a4 Atp1a3 Fxyd2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Asl Gls2 Arg1 Got2 Gpt Slc1a5 Slc1a4 Cps1 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Cacna1g Atp1a2 Cacna1c Atp1a1 Atp1a4 Atp1a3 Fxyd2 Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Chrm2 Kcnk1 Kcnq1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Tpm2 Prkaca Kcne1 Kcnj3 Kcnj2 Dlg1 Kcnj11 Abcc9 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Lck Gab2 Lyn Inpp5d Grb2 Tnf Map2k2 Blnk Rac1 Akt1 Lat Hras Prkca Mapk1 Mapk8 Fcer1a Ms4a2 Csf2 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Mapk3 Prkca Ikbkg Sucnr1 Creb1 Chuk Mapk1 Mapk11 Ikbkb Nos3 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Sult1a1 Fmo1 Cyp2d4 Cyp3a73 Fmo3 Esr1 Ugt1a9 Ugt1a5 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Xdh Prps1l1 Hprt1 Pde10a Adsl Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Nudt2 Adcy2 Entpd8 Gart Itpa Nudt5 Dguok Gmps Pfas Atad1 Atic Gucy1a2 Nme6 Ppat Ampd1 Paics Ada D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Casp3 Arhgdib Casp1 Jun Parp1 Prf1 Arhgap32 Cycs Casp9 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Aldoc Tpi1l2 Aldob Fbp2 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Ggt6 Gsto2 Gclm Gpx1 Casp7 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Tbxas1 Gpx1 Alox12 Prxl2b Alox5 Lta4h Akr1c18 Ptges Cyp4f17 Ptgds Ptgis Cyp2e1 Ephx2 Cyp4f4 Alox15b Ptgs2 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl23 Rplp1 Rpl13a Rpl35a Fau Rps14 Rpl4 Rps15a Rpl18a Rps17l2 Rpl15 Rpl37 Rpl39 Rps10 Rpl17 Rpl18 Rps12 Rpl19 Rpl7 Rps20l2 Rpl30 Rpl10 Rps3a Rps25 Rps26 Rps27 Rps8 Rpl8l1 Rpl27a Rps6 Rpl24 Uba52 Rpl26 Rack1 Rpl27 Rpl28 Rps21 Rps23 Rpl22 Rps16l1 Nars1 Rplp0 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Tpi1l2 Pfkp Slc2a13 Pgk2 G6pc3 Aldob Bpgm INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Hrh2 Adcy2 Creb1 Prkacb Ppp1ca Gnb1 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Fdps Idi1 Hsd17b7 Dhcr24 Soat1 Lss Tm7sf2 Ebp Pmvk Ggps1 Sc5d Cyp51a1 Mvd Msmo1 Acat2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Akt1 Lpar3 Gnb1 Itpr1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Pc Suclg1 Mpc1 Aco2 Aco1 Dlat Dld Idh1 Gls2 Idh2 Idh3a Dlst Pdhb Sdhc Sdhb Sdha Idh3b Cs Dhtkd1 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine)