ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Ilvbl Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Rpia Gpi Taldo1 Tkt Hk2 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Dhfr Mthfd1l Tyms Mtr Mthfd2 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Galt Aldob Aldoc Aldoa Khk Hk2 Gale P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Atf1 Traf6 Srf Mef2d Elk1 Map3k7 Map2k6 Map3k4 Hspb1 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Mapk11 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Rac2 Akt1 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Pik3cb Nos3 Il10 Il11 Ikbkb Spi1 Cxcr1 Stat6 Il15 Irs1 Cxcr2 Stat4 Il13 Il18 Il2ra Irs2 Sla2 Mapk6 Elk3 Elk4 Pdpk1 Akt3 Myc Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Fos Il20ra Il23a Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Il5ra Sos1 Il6st Shc1 Il10rb Il3ra Il10ra Mtor Il2 Il4 Il6 Il5 Il7 Il9 Il6r Il21 Il12rb2 Il11ra1 Srf Il4r Mapk15 Elk1 Spic Il1a Stat5a Stat5b Stat3 Stat2 Stat1 Chuk Cdkn1a Mapkapk2 Cdkn1b Mknk2 Mknk1 Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Alad Qars1 Hmbs Fech Eprs1 Cpox Urod Ppox NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Cacna1g Cacna1c Epb41l2 Chrnb4 Clic6 Ppp1r1b Kcnk3 Chrnb3 Chrnb2 Epb41l1 Slc18a2 Adcy2 Drd2 Drd4 Ppp1ca Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 Chrna4 Gnb1 Flna Gnai1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system Per2 Per1 Per3 Cry1 Cry2 Clock Csnk1d Csnk1e Bmal1 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Pmvk Ggps1 Hmgcr Mvd Fdft1 Lss Fdps Sqle Hmgcs1 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Grin2a Shank1 Shank3 Grm2 Slc1a1 Slc1a3 Slc1a2 Grin1 Slc1a7 Slc17a8 Slc1a6 Slc17a6 Vamp8 Vamp1 Gria4 Vamp3 Gria3 Vamp2 Snap29 Gria2 Snap25 Grik5 Snap23 Stx19 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Stx11 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccnd2 Ccnd3 Ccne1 Rpa3 Cinp P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Pik3cg Pik3cb Pik3cd Pik3c2b Pik3c2a Mapk12 Mapk13 Mapk14 Cdkn1a Hras Mapk11 Pdpk1 Pik3c3 Akt3 Akt2 Ccne1 Akt1 Ccng1 Ctnnb1 Kras Tp53 Tp73 Ppp2cb Rb1 Ppp2ca Pten Nras Pik3c2g Rbl1 Siah1 Cdk2 Pik3r5 Atm Tp63 Atr Pik3r1 Pik3r2 Pik3r3 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Prkcz Hrh1 Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Gng12 Itpr2 Itpr1 Plcg1 Prkcq Plcg2 Prkcg Gnb1 Prkch Prkci Prkcb Prkcd Prkce Prkca Plcb4 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Gna11 Grin2d Grin2c Grin2b Grin2a Prkaca Gnaq Grin1 Prkcb Itpr1 Prkar1b Prkx Grik5 Prkacb Grina Grm1 Plcb4 Grm5 Grik1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Txn1 Mapk9 Pla2g4a Jun Mapk8 Max Ddit3 Map2k3 Myc Bcl2 Elk1 Map2k6 Mapk12 Stat1 Mapk13 Mapk14 Eef2k Map2k4 Mef2c Mknk2 Mknk1 Mapk11 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Kcnk3 Adcy2 Gnao1 Adcy7 Prkar2a Prkaca Prkar2b Kcnk9 Htr1d Htr1f Gnai2 Htr1b Htr1a Gnb1 Gng11 Gnai3 Gnai1 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Prkcz Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Plcg1 Prkcq Plcg2 Prkcg Gnb1 Prkch Oxtr Prkci Prkcb Prkcd Prkce Prkca Plcb4 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Gng10 Adcy2 Gng3 Adcy7 Gng5 Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Htr4 Gnb3 Gnal Gnb5 Gng12 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Prkar1b Cacna1g Prkacb Adcy2 Gnao1 Adcy7 Prkar2a Prkaca Prkar2b Gnb1 Gng11 Gnai3 Gnai1 Cacna1a Cacna1b Gabbr1 Gabbr2 Adcy4 Adcy1 Adcy8 Adcy5 Adcy6 Kcnj3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Ube2t Ube2s Ube2v2 Ube2k Uba6 Ube2d2b Ube2n Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2d2 Ube2e3 Uba3 Ube2d1 Ube2e2 Ube2g2 Ube2l6 Ube2g1 Ube2a Atg7 Sae1 Ube2l3 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway App Erbb4 Apbb3 Nectin1 Trpc6 Afdn Trpc5 Trpc7 Cdh3 Kat5 Wnt5a Trpc1 Cdh1 Trpc4 Wnt5b Wnt9a Kat7 Wnt9b Wnt10a Bace2 Bace1 Ctnnb1 Wnt10b Acta1 Actb Gsk3b Notch4 Actr2 Ern1 Psenen Notch1 Notch2 Notch3 Psen1 Wnt8b Psen2 Wnt8a Fstl1 Wnt16 Lef1 Wnt11 Ncstn Aph1b Lrp1 Lrp6 Lrp2 Lrp3 Lrp4 Lrp5 Wnt6 Rbpjl Wnt7b Wnt3a Dvl1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Cd44 Actg1 Actg2 Wnt3 Tcf7l2 Fzd1 Actbl2 Actc1 Fzd2 Jup Fzd5 Trim3 Fzd4 Fzd6 Fzd9 Fzd8 Wnt2b 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh1b1 Maoa Aldh1a2 Aldh1a1 Maob Aldh3a2 Aldh2 Aldh3a1 Aldh1a3 Aldh16a1 Aldh8a1 Aldh7a1 Aldh9a1 Aldh1l2 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Tp73 Mdm2 Mdm4 Tp63 Tp53 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Ilvbl Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss2 Acss3 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Pank3 Pank4 Pank1 Dcakd METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Ireb2 Aco1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Vav1 Vav2 Map3k3 Map3k2 Blnk Btk Cd79b Pik3cg Ptpn6 Pik3cb Lyn Pik3cd Ptprc Ppp3ca Ppp3cb Nfkbia Grb2 Mapk10 Map2k2 Map2k1 Hras Ikbkb Fos Sos1 Mapk12 Mapk13 Chuk Mapk14 Itpr3 Itpr2 Itpr1 Mapk11 Mapk1 Mapk9 Jun Mapk8 Mapk3 Rac2 Rac1 Araf Plcg2 Nras Prkcb Prkcd Nfkbil1 Raf1 Cd22 Vav3 Syk P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Akt3 Akt2 Akt1 Eif4ebp1 Tp53 Tsc2 Tp73 Ppp2cb Tsc1 Igbp1 Ppp2ca Prkaa1 Prkab2 Rps6kb1 Prkaa2 Prkab1 Prkag1 Tp63 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Plcb3 Plcb2 Plcb1 Dagla Lpl Pla1a MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Pmm1 Mpi Gmppa Pmm2 Gmds Gmppb MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrnp40 Zrsr2 Prpf3 Snrpb2 Snrpa HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Txn1 Hif1a Akt3 Rorc Arnt Akt2 Txn2 Crebbp Akt1 Egln2 Egln3 Vhl Mtor THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Psmc3ip Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Tbp Brf1 Tbpl2 Tbpl1 Creb5 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Polr2sl1 Taf8 Taf7 Taf6 Gtf2e1 Taf2 Prkar1b Prkar2a Crebbp Prkar2b Gtf2a1l Polr2c Taf1c Taf9 Creb3l3 Creb3l4 Polr2h Polr2e Creb3l1 Ttf2 Creb3l2 Polr2f Ttf1 Taf9b Taf11 Gtf2h1 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Gng10 Adcy2 Gnao1 Gng3 Adcy7 Gng5 Gng7 Gnai2 Gng8 Gngt2 Gnb1 Gnb2 Gnai3 Gnb4 Gnai1 Gnb3 Oprd1 Gnb5 Pomc Gng12 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b2 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Avp Oxt GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 UNTITLED%PANTHER PATHWAY%P00019 untitled Prkcz Nos3 Map2k2 Map2k1 Akt3 Akt2 Plcb4 Plcb3 Gna11 Gna14 Plcb2 Plcb1 Gnaq Itpr3 Itpr2 Itpr1 Prkar1b Prkacb Ednrb Ednra Mapk1 Pla2g4a Adcy3 Edn1 Edn2 Edn3 Adcy10 Adcy2 Gucy1b1 Mapk3 Prkg2 Gucy1a1 Adcy7 Gucy1a2 Akt1 Prkaca Prkar2a Prkar2b Araf Prkcq Prkcg Prkch Prkci Prkcb Gnal Prkcd Adcy4 Prkce Adcy1 Prkca Adcy8 Raf1 Adcy5 Adcy6 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Dhfr Gch1 Tyms 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Prkcz Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Htr2a Htr2c Plcg1 Htr2b Prkcq Plcg2 Prkcg Gnb1 Gng11 Prkch Prkci Prkcb Prkcd Prkce Prkca Plcb4 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Flnb Tln1 Vcl Vasp Pxn Col17a1 Col13a1 Itga7 Pik3cg Fn1 Itga8 Pik3cb Arl1 Pik3cd Itga5 Itga6 Itga9 Pik3c2b Itga3 Pik3c2a Itga4 Ptk2 Elmo2 Map2k2 Itga1 Elmo1 Map2k1 Itga2 Hras Itga10 Col4a3 Arpc3 Col4a1 Cav1 Arpc2 Col4a2 Col8a1 Col4a5 Arpc5 Parvb Parva Rap2b Col16a1 Arf1 Mapk6 Col12a1 Itgax Ilk Itgav Rnd2 Rhoc Rnd3 Rhoa Rnd1 Rhob Itgam Asap1 Itgal Actb Arhgap10 Rap1a Col3a1 Rap1b Itgad Itgb8 Itgb6 Itgb7 Sos1 Itgb1 Shc1 Itga2b Itgb4 Rras Actn2 Itgb2 Actn1 Actn4 Crk Arf6 Arhgap26 Col15a1 Col11a1 Col11a2 Src Dock1 Bcar1 Dnajc27 Lamb2 Lamb3 Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Col6a2 Ptk2b Actg1 Lims2 Lamc3 Lamc1 Actbl2 Flna Map3k3 Map3k2 Mapk10 Map3k4 Mapk13 Map2k4 Mapk9 Mapk8 Braf Pik3c3 Map2k3 Mapk3 Rac2 Rac1 Araf Col14a1 Itgbl1 Crkl Arfgap1 Col1a2 Col5a2 Nras Col5a3 Col5a1 Dmbt1 Col9a2 Col9a1 Arpc1b Lama5 Arpc1a Raf1 Lama1 Pik3r1 Lama2 Pik3r2 Lama4 Pik3r3 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Arhgap8 Shc2 Pik3cg Pik3cb Pik3cd Map2k2 Map2k1 Hras Ikbkb Stat6 Stat4 Mapk6 Elk4 Pdpk1 Myc Akt2 Jak3 Fos Arhgap10 Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Shc1 Arhgap26 Mapk15 Stat5a Stat5b Stat3 Stat2 Stat1 Chuk Ehf Srgap1 Srgap3 Rab11b Arhgap5 Arhgap4 Erf Erg Arhgap9 Shc3 Rasa2 Rasa1 Pdgfrb Pdgfra Pdgfa Pdgfrl Pdgfb Grap Fli1 Rps6kc1 Fev Gabpa Nck2 Jak2 Jak1 Nck1 Arhgap15 Arhgap12 Gab1 Gab2 Etv3 Spdef Elf1 Elf2 Gsk3a Elf3 Elf4 Elf5 Ophn1 Usf2 Vav3 Grap2 Elp1 Vav1 Rerg Vav2 Nin Pkn2 Map3k2 Ninl Arhgap42 Grb2 Mapk10 Rps6kb1 Pik3r5 Srf Elk1 Map3k4 Mapkapk2 Itpr3 Rps6ka5 Itpr2 Mknk2 Itpr1 Mknk1 Mapk1 Jun Mapk8 Braf Ets1 Pik3c3 Mapk3 Plcg1 Araf Plcg2 Nras Arhgap1 Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Slc44a3 Actr1a Myo3b Chrnb1 Myo7a Slc18a3 Myo7b Slc6a8 Chrna10 Myh2 Myh3 Myh8 Myh9 Myh4 Myh6 Myh7 Myo1c Myo1b Myo1e Myo1d Myo5c Myo5b Myo1a Myh11 Myo1g Myo1f Plekhh3 Myh10 Myh7b Myo6 Myo18b Myo5a Myo9a Slc5a7 Chrnd Chrne Chrng Chrna2 Chrna1 Myo10 Chrna9 Acta1 Myo15a Actb Myo16 Myo19 Actg1 Actg2 Actbl2 Actc1 Chrnb4 Chrnb3 Chrnb2 Chrna3 Chrna6 Chrna5 Chrna4 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Stat6 Jak3 Stat5a Stat5b Stat4 Stat3 Jak2 Jak1 Stat1 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Phgdh Psph Psat1 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Vasp Pik3cg Pik3cb Pik3cd Pik3c2b Pik3c2a Rac2 Rac1 Plcg1 Plcg2 Ntn1 Ntn3 Nfatc4 Nfatc3 Nfatc2 Ablim1 Dcc Pik3r5 Ntng1 Unc5b Unc5d Unc5c Pik3r1 Pik3r2 Pik3r3 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc6a15 Slc6a20a Slc6a16 Slc18a1 Slc6a2 Slc18a2 Slc6a3 Slc6a19 Slc6a18 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Ugt2b7 Fmo3 Cyp2a3 Ugt1a2 Ugt1a3 Inmt Ugt1a5 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mat2a Mtr Mat1a CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Myo3b Myh2 Myh3 Myh8 Myh9 Myh4 Myh6 Myh7 Arpc3 Arpc2 Myh11 Arpc5 Myh10 Myh7b Rhoc Acta1 Actb Diaph2 Diaph1 Tubb2b Tubb2a Cfl1 Actg1 Cfl2 Actg2 Mylk2 Pfn1 Mylk3 Pfn3 Actbl2 Pfn2 Actc1 Stmn1 Pak1 Pak6 Stmn4 Pak3 Pak2 Pak5 Pak4 Tubb5 Tubb6 Tubb3 Mylk Limk1 Arpc4 Rock2 Rac2 Tubb4b Rock1 Rac1 Arpc1b Arpc1a INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Elk1 Map2k2 Map2k1 Rps6kb1 Rps6ka5 Irs1 Mapk1 Irs2 Rasa1 Map2k3 Mapk3 Ins2 Insr Igf2r Fos Igf2 Igf1 Insrr Rps6ka3 Igf1r Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Raf1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Ifngr2 Ifng Ifngr1 Jak2 Jak1 Stat1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Uckl1 Upp1 Upp2 Uprt Nme3 Nme2 Nme4 Uck1 Uck2 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Cacna1e Grm4 Grm7 Grm6 Grm8 Vti1a Grin2a Slc17a7 Stx1b Cacnb1 Slc1a1 Stx1a Slc1a3 Slc1a2 Grin1 Slc1a7 Slc1a6 Vamp8 Vamp1 Gria4 Vamp3 Gria3 Vamp2 Snap29 Gria2 Snap25 Grik5 Snap23 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkar1b Prkx Prkacb Grm1 Grm5 Adcy10 Prkaca Prkar2a Prkar2b Gnai2 Gnb1 Gnai3 Gnai1 Cacna1a Cacna1b APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Pik3cg Pik3cb Pik3cd Casp9 Atf2 Birc3 Nfkbia Eif2ak2 Birc2 Mapk10 Tnf Madd Bcl2l11 Tnfrsf1b Tnfrsf1a Tradd Ikbkb Nfkb2 Nfkb1 Traf2 Cycs Bcl2l1 Xiap Endog Tnfsf10 Rela Map3k1 Apaf1 Tnfrsf10b Lta Fadd Atf7 Ltb Atf6 Akt3 Atf4 Atf3 Akt2 Jdp2 Aifm1 Map2k7 Gzmf Map4k3 Fos Atf6b Cradd Tp53 Bak1 Eif2s1 Casp8 Casp7 Prkra Casp3 Bik Ripk1 Map4k2 Diablo Bax Rel Fas Faslg Daxx Map3k14 Atf1 Chuk Map2k4 Mapk1 Mapk9 Jun Mapk8 Map2k3 Mapk3 Bcl2 Akt1 Igf2r Prkcq Prkcg Prkch Prkcb Prkcd Prkce Prkca LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Pik3cg Pik3cb Pik3cd Atf2 Grb2 Mapk10 Map2k2 Map2k1 Hras Map3k1 Pdpk1 Akt3 Rhoc Rhoa Map2k7 Rhob Kras Gsk3b Rps6ka3 Rps6ka6 Rps6ka1 Rps6ka2 Sos1 Shc1 Tiam1 Ralgdsl1 Rala Ralb Exoc2 Pld1 Pld2 Ralgds Srf Elk1 Map2k6 Map3k4 Stat3 Mapk12 Mapkapk3 Stat1 Mapk13 Mapk14 Mapkapk2 Map2k4 Pak1 Mapk11 Pak3 Pak2 Mapk1 Mapk9 Jun Mapk8 Braf Ets1 Pik3c3 Map2k3 Mapk3 Rac2 Akt1 Rac1 Araf Nras Gsk3a Raf1 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Plcb3 Gng10 Plcb2 Plcb1 Grk3 Grk2 Elk1 Gng3 Agtr1a Arrb2 Arrb1 Gng7 Egr1 Gnaq Agt Gng8 Gngt2 Map2k2 Map2k1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Itpr1 Mapk1 Mapk3 Gnb1 Gng11 Prkca Raf1 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Brf1 Tbpl1 Gtf2a1 Gtf2a2 Mterf2 Gtf2b Taf8 Taf7 Taf6 Gtf2e1 Taf2 Gtf2a1l Polr2c Taf1c Taf9 Polr2h Polr2f Ttf1 Taf9b Taf11 Gtf2h1 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Gadd45g Sumo2 Chek2 Sumo3 Cdkn1a Gadd45b Gadd45a Hdac1 Sfn Cdkn2a Traf2 Mta2 Ccnb1 Gtse1 Cdk1 Sirt1 Cdc25c Pdpk1 Akt3 Akt2 Ccne1 Akt1 Crebbp Tp53 Tp73 Mdm2 Mdm4 Pten Cdk2 Atm Tp63 Atr THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Cacna1e Prkcz Cacnb1 Vamp8 Vamp1 Vamp3 Vamp2 Snap29 Snap25 Snap23 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Trh Trhr Stx3 Cga Cacnb3 Cacnb4 Cacnb2 Tshb Plcg1 Prkcq Plcg2 Prkcg Gnb1 Prkch Prkci Prkcb Cacna1a Cacna1b Prkcd Prkce Prkca ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b7 Hsd17b6 Soat2 Hsd17b3 Soat1 Hsd17b1 Hsd17b2 Lipa Cyp19a1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10a Wnt10b Acta1 Actb Actr2 Wnt8b Wnt8a Fstl1 Wnt16 Lef1 Wnt11 Wnt6 Wnt7b Wnt3a Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Actg1 Actg2 Wnt3 Tcf7l2 Fzd1 Actbl2 Actc1 Fzd2 Fzd5 Fzd4 Fzd6 Fzd9 Fzd8 Wnt2b Pcdhb2 Pcdhb1 Cdh9 Pcdhb3 Cdh8 Cdh7 Pcdhb5 Cdh6 Cdh5 Pcdhgb7 Pcdh10 Pcdhgb2 Cdh2 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdhgc3 Pcdhb17 Pcdhb19 Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac2 Cdhr2 Pcdha13 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ctnnb1 Ptpn1 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Ctnnd2 Pcdhga2 Ctnnd1 Pcdhga3 UNTITLED%PANTHER PATHWAY%P06664 untitled Tgif1 Skil Rela PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Suclg1 Mdh1 Ogdh Aco2 Sdhc Pdk2 Cs Fh Pdha2 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Odc1 Azin1 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Upb1 Dpysl5 Nt5e Aldh6a1 Dpys Dpyd Dpysl2 Dpysl3 Abat Cda ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Gng10 Adcy2 Gng3 Adcy7 Prkar2a Prkaca Gng5 Prkar2b Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnal Gnb5 Adrb1 Gng12 Prkx Prkacb INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Irs2 Pdpk1 Foxo3 Ins2 Insr Igf2r Igf2 Igf1 Tsc2 Gsk3b Insrr Tsc1 Mdm2 Igf1r Mdm4 Pten Gsk3a Foxo1 Irs1 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Gng10 Adcy2 Gng3 Adcy7 Prkar2a Prkaca Gng5 Prkar2b Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnal Gnb5 Gng12 Hrh2 Prkx Prkacb BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gng10 Adcy2 Gng3 Adcy7 Gng5 Gng7 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnal Gnb5 Gng12 Adrb3 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Nt5e Ampd3 Gda Xdh METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Crhr1 Gna11 Gng10 Gna14 Gng3 Gng5 Gng7 Gnaq Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnal Gnb5 Pomc Gng12 Crh Crhr2 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Aph1b Pkn2 Prkcz Mapk15 Cacnb1 Mapk12 Mapk10 Mapk13 Mapk14 App Cacna1c Mapk11 Mapk1 Mapk9 Cacna1f Kat5 Cacna1d Mapk6 Mapk8 Klc1 Cacnb2 Adam17 Mapk4 Klc4 Mapk3 Klc3 Klc2 Apba1 Apba2 Bace2 Apba3 Bace1 Pkn1 Prkcq Prkcg Prkch Psenen Prkci Prkcb Psen1 Prkcd Psen2 Prkce Prkca Ncstn CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Rhoc Rac2 Rac1 Cxcl12 Slit1 Slit2 Slit3 Robo1 Ntn1 Cxcr4 Ntn3 Abl1 Srgap1 Dcc Ntng1 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Dscaml1 Dhodh Cad Ctps2 Cps1 Ctps1 Nme3 Nme1 Nme2 Nme4 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Egfr Phldb2 Map3k3 Shc2 Nf1 Map3k2 Rras2 Dab2ip Pebp4 Pik3cg Spry2 Prkcz Spry1 Pik3cb Spry4 Pik3cd Pebp1 Pik3c2b Pik3c2a Mapk10 Map2k2 Map2k1 Hras Stat6 Erbb4 Stat4 Akt3 Akt2 Map2k7 Sos1 Shc1 Pik3r5 Rras Map2k6 Stat5a Map3k4 Stat5b Stat3 Mapk12 Stat2 Stat1 Mapk13 Mapk14 Map2k4 Mapk11 Prkd3 Shc3 Mapk1 Rasa2 Mapk9 Rasa1 Prkd1 Mapk8 Braf Prkd2 Pik3c3 Map2k3 Mapk3 Grap Rac2 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Gab1 Prkch Gab2 Prkci Nras Prkcb Prkcd Prkce Prkca Erbb2 Raf1 Erbb3 Mras Rasal2 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Fgb Fga Mmp13 Mmp1 Mmp3 Fgg Plat Plg Mmp9 Plau Serpinf2 Serpine1 Serpinb2 PNAT%PANTHER PATHWAY%P05912 PNAT Slc6a3 Gng3 Gng8 Vamp8 Gnb2 Vamp1 Gnb4 Gnb3 Vamp3 Epb41l3 Vamp2 Drd1 Snap29 Drd5 Ppp1cc Snap25 Gnaz Prkx Prkacb Snap23 Epb41l2 Clic6 Stx3 Ppp1r1b Kcnk3 Epb41l1 Slc18a2 Adcy2 Drd2 Drd4 Adcy7 Ppp1ca Prkar2a Prkaca Prkar2b Kcnk9 Epb41 Gnai2 Gnb1 Gng11 Flna Gnai3 Gnai1 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Stk36 Fbxw11 Gli1 Btrc Crebbp Shh Smo Ptch1 Sufu MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Gng10 Gng3 Gng5 Slc18a3 Gng7 Slc6a8 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkar1b Prkx Prkacb Kcnj9 Adcy10 Kcnj6 Kcnj5 Slc5a7 Chrm2 Gnao1 Chrm4 Gnat2 Prkar2a Prkaca Gnat1 Prkar2b Gnai2 Gnb1 Gng11 Gnai3 Gnai1 Kcnj3 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Gfpt1 Gfpt2 Amdhd2 Gnpda2 Npl TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Atf2 Mapk10 Hras Crebbp Bmp10 Bmp8a Bmp15 Dcp1b Lefty2 Acvr1 Foxh1 Smurf2 Smurf1 Jund Acvr1c Snip1 Rras Skil Lefty1 Tgfb2 Tgfb3 Gdnf Cited1 Acvrl1 Cited2 Acvr1b Amhr2 Fosl1 Mstn Gdf2 Bmpr1a Gdf3 Gdf6 Bmp7 Map3k7 Bmp6 Bmp5 Gdf7 Bmp4 Mapk12 Bmpr2 Smad1 Mapk13 Bmp3 Mapk14 Smad2 Gdf9 Nodal Bmp2 Smad3 Smad4 Bmp1 Smad9 Acvr2a Tll2 Gdf15 Inhba Inhbb Mapk11 Acvr2b Junb Mapk1 Inhbc Mapk9 Tgfbr1 Jun Smad5 Mapk8 Tgfbr2 Smad6 Inhbe Smad7 Mapk3 Gdf11 Gdf10 Nras BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation Fgb Fga Fgg Plat Plg Plau F2r Kng2l1 Klkb1 Gp5 Proc Gp9 Gp1bb F13b Gp1ba Procr Vwf F10 F12 Proz Tfpi F2 Itga2b Serpina10 F3 Thbd F7 F8 F9 Pros1 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Ptger1 Gna11 Foxo4 Gngt1 Gna14 Ywhaz Pik3cb Casp9 Nos3 Gnaq Gngt2 Gnb2 Gnb4 Gnb3 Rps6kb1 Gnb5 Foxo1 Irs1 Pdpk1 Akt3 Akt2 Gnat2 Akt1 Foxo3 Insr Gnai2 Gsk3b Gnb1 Gnai3 Gnai1 Nras Sos1 Pik3r5 Pik3r1 Pik3r2 Pik3r3 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Grm4 Grm7 Grm6 Grm8 Drd1 Drd5 Kcnj9 Kcnj6 Kcnj5 Chrm2 Chrm4 Rap1a Gsk3b Rap1b Adcy2 Drd2 Drd4 Prkaca Gnb1 Gnai1 Gsk3a Gngt1 Adora2b Adora2a Adra2c Adra2b Htr6 Htr7 Grm2 Oprl1 Phka1 Phka2 Adrb2 Adra1b Adra1a Adra1d Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Oprm1 Htr5a Phkb Chrm1 Chrm3 Chrm5 Hrh4 Hrh3 Adora1 Gnrhr Gys1 Gys2 Clta Cltb Cltc Mtnr1a Creb1 Creb3 Phkg1 Phkg2 Crebbp Mtnr1b Pygb Pygl Pygm Gpr50 Oprk1 Creb3l3 Creb3l4 Creb3l1 Creb3l2 Gng10 Hrh1 Gng3 Creb5 Gng5 Gng7 Gng8 Gngt2 Gnb2 Oprd1 Adrb1 Gng12 Hrh2 Adrb3 Prkar1b Prkacb Grm1 Grm5 Adcy3 Adcy7 Prkar2a Prkar2b Htr2a Htr1d Htr2c Htr1f Htr2b Gnai2 Htr1b Htr1a Gnai3 Htr4 Gnal Adcy4 Adcy1 Adcy8 Adcy5 Adcy6 Kcnj3 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Map3k3 Map3k2 Pik3cg Spry2 Ptpn6 Prkcz Spry1 Pik3cb Spry4 Pik3cd Pebp1 Pik3c2b Pik3c2a Mapk10 Map2k2 Map2k1 Hras Akt3 Akt2 Map2k7 Map3k6 Frs2 Frs3 Fgfr3 Fgfr4 Fgfr1 Sos1 Fgfr2 Shc1 Map2k6 Map3k4 Mapk12 Mapk13 Mapk14 Map2k4 Mapk11 Shc3 Mapk1 Rasa2 Mapk9 Rasa1 Mapk8 Pik3c3 Map2k3 Mapk3 Grap Rac2 Akt1 Rac1 Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Prkcd Prkce Prkca Raf1 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Cad Asl Nags Cps1 Ass1 Otc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Calml3 Rgs9 Gng10 Gngt1 Cngb1 Pde6a Pde6b Cngb3 Rcvrn Gng13 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb5 Gng12 Gnat1 Gnb1 Cnga3 Pdc Cnga1 Grk1 Rho ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Ywhaz Pld2 Slc6a3 Psma4 Mapk15 Psma3 Elk1 Psma6 Psma5 Ccne2 Psma2 Psma1 Mapk12 Mapk10 Cask Ywhah Ywhag Mapk14 Ywhae Th Ywhab Sfn Psmb10 Sncaip Psmb7 Prkn Psmb1 Gpr37l1 Septin5 Psmb3 Stx7 Septin2 Septin1 Mapk1 Gpr37 Mapk9 Stx12 Ndufv2 Mapk8 Psma7 Snca Mapk3 Ccne1 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Gna11 Gng10 Pkn2 Gna14 Grin2a Prkcz Gng3 Gng5 Slc18a3 Gng7 Gnaq Grin1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Itpr2 Chrm1 Itpr1 Chrm3 Grin2d Grin2c Grin2b Slc5a7 Pkn1 Prkcq Prkcg Gnb1 Gng11 Prkch Prkci Prkcb Prkcd Prkce Prkca Plcb4 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Gng10 Pdyn Penk Adcy2 Gng3 Adcy7 Gng5 Gng7 Gnai2 Gng8 Gngt2 Gnb1 Gnb2 Gnai3 Gnb4 Gnai1 Gnb3 Oprd1 Gnb5 Gng12 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Rfc5 Pold2 Pold1 Rfc3 Rfc4 Pcna Rfc1 Rfc2 H3f3a Rpa2 Top2a Top1 Dna2 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Mcee Pccb DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Ppat Nme6 Guk1 Gart Dscaml1 Adsl Rrm2 Impdh2 Rrm2b Gmps Ak3 Nme3 Ak2 Nme1 Nme2 Ak4 Nme4 Adss2 Atic Nme7 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway F13b Rxra Vdr Rara Gc HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Cacna1e Grm4 Gngt1 Grm7 Adora2b Grm6 Adora2a Grm8 Prkcz Rap1gap Grm2 Rasgrp3 Oprl1 Rasgrp4 Rasgrp1 Rasgrp2 Arhgef1 Bdkrb2 Bdkrb1 Gpr45 Sstr5 Sstr4 Sstr3 Sstr2 Sstr1 Oprm1 Drd1 Chrm1 Drd5 Chrm3 Chrm5 Adora1 Gnrhr Clta Cltb Cltc Chrm2 Chrm4 Rhoa Oprk1 Rap1a Rap1b Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Gng13 Dnajc27 Gng3 Gng5 Gng7 Gnaq Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Oprd1 Itpr3 Gng12 Itpr2 Itpr1 Grm1 Grm5 Drd2 Gnao1 Drd4 Prkcq Prkcg Gnb1 Prkch Prkci Prkcb Cacna1a Cacna1b Prkcd Prkce Prkca ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Grb14 Map2k1 Fgf1 Hras Dok1 Dok2 Dok3 Axin1 Grb7 Pdgfc Tcf7 Efnb1 Jag2 Efnb2 Jag1 Map3k1 Pla2g4d Angpt1 Apc2 Epha3 Wnt5a Ephb1 Ephb2 Dll1 Ephb3 Akt3 Wnt5b Dll3 Rhoc Dll4 Akt2 Dlk1 Rhoa Apc Wnt10a Tek Rhob Wnt10b Fos Gsk3b Notch4 Notch1 Notch2 Sos1 Shc1 Crk Pld1 Pld2 Src Rbpjl Wnt7b Dvl1 Dvl3 Wnt7a Stat3 Wnt2 Stat1 Wnt1 Tcf7l2 Fzd1 Fzd2 Fzd5 Rasa1 Pdgfrb Wnt2b Pdgfra Pdgfa Pdgfb Grap F2r Nck2 Jak1 Nck1 Ctnnb1 Frs2 Frs3 Fgfr1 Hspb1 Mapkapk3 Mapk14 Mapkapk2 Map2k4 Pak1 Prr5 Pak3 Prkd3 Pak2 Mapk1 Pla2g4a Prkd1 Jun Mapk8 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Akt1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Crkl Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Dscaml1 Rrm2 Rrm2b Dtymk Nme3 Nme1 Tyms Nme2 Nme4 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Stx1b Stx1a Syt5 Syt3 Syt2 Syt1 Syt11 Syt12 Syt7 Vamp1 Syt6 Unc13c Rab3a Stxbp1 Unc13b Syt15 Stx2 Snap25 Unc13d GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Pxn Pik3cb Atf2 Ptk2 Mmp3 Map2k2 Map2k1 Plau Bcl2l1 Irs1 Elk4 Cdh1 Itgav Pdpk1 Rhoa Foxo3 Fos Gsk3b Rps6ka3 Rps6ka1 Casp3 Sos1 Itgb1 Shc1 Bax Nr2c2 Clu Ier3 Rps6 Map3k14 Sp1 Crk Sp3 Elavl1 Akt1s1 Yes1 Snai1 Tcf4 Src Hbegf Nos1 Bcar1 Hdac7 Akap1 Cckbr Arrb2 Pparg Egr1 Gucy2e Arhgef28 Stat3 Cd38 Ptgs2 Camk4 Map2k5 Ptpn11 Ptk2b Tpcn1 Bad Cck Gast Map3k11 Slc18a2 Prkaca Jak2 Gnb1 Lyn Ppp3ca Nfkbia Grb2 Mapk10 Eif4ebp1 Rps6kb1 Creb1 Ctnnb1 Nfatc2 Traf6 Srf Odc1 Mef2d Elk1 Map2k6 Hspb1 Mapk14 Ywhab Eif4e Map2k4 Mef2c Foxo1 Itpr1 Pak1 Prkacb Mapk1 Mapk9 Pla2g4a Prkd1 Jun Mapk8 Braf Prkd2 Mapk3 Bcl2 Akt1 Rock1 Rac1 Plcg1 Araf Prkcq Prkch Prkcb Prkcd Prkce Prkca Adcy1 Raf1 Pik3r1 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Tpi1l2 Pfkm Aldoa Gpi Pklr Eno1 Hk2 Bpgm Eno2 Pfkl Pkm Pgk1 Pgam2 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Ncor2 Cirsr Maml1 Numb Dll3 Dll4 Dlk1 Rbpjl Notch4 Notch1 Notch2 Notch3 Jag2 Jag1 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Csad Gad1 Aldh5a1 Gad2 Abat FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Casp9 Mapk10 Map2k4 Apaf1 Mapk9 Jun Fadd Mapk8 Faf1 Parp3 Parp2 Parp1 Cflar Lmnb1 Lmnb2 Casp8 Gsn Casp7 Casp6 Capg Casp3 Lmna Scin Dffb Fas Faslg Daxx INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Pik3cg Prkcz Pik3cb Pik3cd Arpc3 Ikbkb Nfkb2 Cxcr1 Arpc2 Cxcr2 Arpc5 Rela Col12a1 Pdpk1 Akt3 Rhoc Akt2 Rhoa Acta1 Itgal Actb Itgb7 Sos1 Jund Itgb1 Shc1 Rras Il2 Stat3 Chuk Col6a2 Ptk2b Actg1 Actg2 Actbl2 Actc1 Junb Adcy2 Grap Prkaca Jak2 Vwf Gnai1 Cxcr3 Cxcr5 Cxcl10 Fpr1 Fpr3 Ccr10 Ccr1 Xcr1 Ccrl2 Ltb4r2 Vav1 Rhog Ccr9 Ccr8 Ccr7 Ccr6 Ccr5 Myo3b Ccr4 Ccr3 Ccr2 Cx3cr1 Ifnar1 Camk2d Ccl11 Myh2 Ccl12 Myh3 Ccl7 Myh8 Camk2a Myh9 Ccl5 Myh4 Ccl4 Myh6 Ccl3 Myh7 Ccl2 Pf4 Prex1 Cx3cl1 Nfat5 Ccl22 Ccl20 Ccl21 Myh11 Myh10 Myh7b Kras Nfatc4 Nfatc3 Nfatc2 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng5 Plcl1 Gng7 Gnaq Gng8 Cask Plcz1 Plce1 Gnb3 Mylk2 Itpr3 Mylk3 Gng12 Itpr2 Itpr1 Prkx Pak1 Prkacb Pak6 Pak3 Pak2 Mapk1 Pak5 Pak4 Jun Mylk Mapk3 Arpc4 Gnao1 Rac2 Akt1 Rock1 Rac1 Plcg1 Araf Gnai2 Col14a1 Plcg2 Gnai3 Cxcr4 Ifng Nras Prkcb Arpc1b Prkce Arpc1a Raf1 Adcy5 Adcy6 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Prtfdc1 Gda Pnp Hprt1 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Rhog Grin2a Grin1 Grik5 Arpc5 Grik2 Hip1 Apaf1 Grik1 Bdnf Grik4 Ift57 Grik3 Dync1h1 Grin2d Dnal4 Cltb Grin2c Dctn1 Grin2b Rhoj Rhoq Dync1i2 Dync1i1 Ap2a2 Ap2a1 Map2k7 Crebbp Hap1 Hip1r Fos Kalrn Acta1 Htt Tp53 Actb Gapdhs Dync1li2 Tp73 Actr2 Dync2h1 Casp8 Dync1li1 Dnai2 Dynll1 Casp3 Dynll2 Capn9 Cyc1 Capn5 Capn7 Capn6 Capn1 Tp63 Capn3 Capn2 Dlg4 Sp1 Dnah5 Dnah8 Cyfip1 Capns1 Capns2 Capn11 Capn12 Tbp Tubb2b Tubb2a Actg1 Actg2 Map2k4 Actbl2 Actc1 Map3k10 Mapk9 Jun Tubb5 Tubb6 Tubb3 Rac2 Tubb4b Rac1 Arpc1b Arpc1a ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Acly Pc Pklr Me1 Clybl Pck1 Cs Pkm Pdha2 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Vav1 Vav2 Pik3cg Pik3cb Pik3cd Ptprc Ppp3ca Ppp3cb Nfkbia Map2k2 Map2k1 Hras Ikbkb Map3k1 Akt3 Akt2 Fos Sos1 Zap70 Cd28 Cd86 Cd80 Lck Chuk Lcp2 Cd3g Cd247 Cd3e Cd3d Ppp3cc Lat Itpr1 Pak1 Pak3 Pak2 Mapk1 Mapk9 Jun Mapk8 Braf Pik3c3 Mapk3 Akt1 Rac1 Nck2 Plcg1 Araf Nck1 Prkcq Nras Raf1 Pik3r1 Vav3 Pik3r2 Grap2 Pik3r3 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Traf6 Elk1 Map3k7 Nfkbia Map2k2 Chuk Mapk14 Map2k1 Ikbkb Map3k8 Ikbke Tbk1 Ticam2 Irak4 Ecsit Nfkbie Tollip Irak1 Mapk9 Tlr10 Jun Myd88 Mapk8 Tank Irf3 Tlr7 Map2k3 Tlr6 Mapk3 Tirap Tlr4 Tlr3 Tlr2 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Psat1 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Axin1 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Wnt10a Wnt10b Wnt8b Wnt8a Fstl1 Wnt16 Lef1 Wnt11 Lrp6 Lrp5 Wnt6 Wnt7b Wnt3a Arrb2 Dvl1 Arrb1 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Hdac1 Wnt3 Tcf7l2 Fzd1 Fzd2 Fzd5 Fzd4 Fzd6 Fzd9 Fzd8 Wnt2b Pcdhb2 Pcdhb1 Cdh9 Pcdhb3 Cdh8 Cdh7 Pcdhb5 Cdh6 Cdh5 Pcdhgb7 Pcdh10 Pcdhgb2 Cdh2 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdhgc3 Pcdhb17 Ppp3ca Pcdhb19 Ppp3cb Cdh24 Cdh23 Cdh20 Celsr3 Celsr1 Pcdhb10 Celsr2 Pcdh20 Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac2 Cdhr2 Pcdha13 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Cdh18 Cdh17 Pcdh11x Cdh16 Cdh15 Cdh13 Crebbp Cdh12 Cdh11 Cdh10 Pcdh8 Pcdh7 Pcdh9 Pcdhga5 Pcdhga7 Pcdhga8 Pcdhga1 Pcdhga2 Pcdhga3 Ppp3cc Arr3 Smarce1 Srcap Tbl1x Prkcq Nlk Kremen2 Prkcg Kremen1 Prkch Siah2 Prkci Ino80 Csnk2a2 Prkcb Ep400 Hells Hltf Prkcd Csnk1a1 Ppp2r5d Prkce Smarcal1 Prkca Ppp2r5c Ppp2r5b Ppp2r5a Ankrd6 Ppp2r5e Chd1l Arid1a Pygo2 Pygo1 Tle4 Tle3 Tle2 Prkcz Tle1 Ctnna2 Ctnna1 Csnk1g3 Hdac3 Hdac2 Csnk1g2 Tbl1xr1 Smarcb1 Hdac8 Csnk2b Smarca2 Sag Smarca1 Smarca4 Smarca5 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd1 Smarcd3 Smarcd2 Smarcc2 Smarcc1 Fbxw11 Btrc Gsk3b Smad1 Smad4 Smad5 Gnb1 Csnk1d Csnk1e Ctnnb1 Ppp2cb Ppp2ca Nfatc4 Nfatc3 Siah1 Nfatc2 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Gng13 Plcb1 Gng3 Gng5 Gng7 Gnaq Gng8 Gnb2 Gnb4 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Ada Prtfdc1 Pnp Xdh Hprt1 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Cacna1e Gng10 Stx1b Grm2 Gng3 Cacnb1 Gng5 Stx1a Gng7 Gng8 Gngt2 Vamp8 Gnb2 Vamp1 Gnb4 Gnb3 Vamp3 Gnb5 Vamp2 Snap29 Prkar1b Snap25 Prkx Prkacb Snap23 Adcy10 Gnao1 Gnat2 Prkar2a Prkaca Prkar2b Gnai2 Gnb1 Gng11 Gnai3 Gnai1 Cacna1a Cacna1b UNTITLED%PANTHER PATHWAY%P05916 untitled Gng10 Pdyn Adcy2 Gnao1 Gng3 Adcy7 Gng5 Gng7 Gnai2 Gng8 Gngt2 Oprk1 Gnb1 Gnb2 Gnai3 Gnb4 Gnai1 Gnb3 Gnb5 Gng12 Avp Oxt AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Nrp1 Dpysl4 Plxnb1 Sema3a Sema4d Cdk5 Rhoa Fes Rac2 Crmp1 Rac1 Frk Fyn Dpysl2 Arhgef1 Dpysl5 Dpys Pak1 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Plcb3 Plcb2 Plcb1 Gnao1 Gng3 Gng5 Cnr1 Gng7 Gng8 Gngt2 Gnb1 Gng11 Gnb2 Gnai3 Gnb4 Gnai1 Gnb3 Cacna1a Cacna1b Cacna1g Grm1 Grm5 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Psmc3ip Tbp Tbpl2 Tbpl1 Rrn3 Polr1b Taf1a Taf1b Taf8 Cavin1 Taf1c Ubtf Ttf1 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Cda BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Gng10 Adcy2 Gng3 Adcy7 Prkar2a Prkaca Gng5 Prkar2b Gng7 Adrb2 Gng8 Gngt2 Gnb1 Gnb2 Gnb4 Gnb3 Gnal Gnb5 Gng12 Prkx Prkacb ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Gng10 Gng3 Gng5 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Oprd1 Gnb5 Oprm1 Gng12 Prkx Prkacb Pdyn Adcy2 Creb1 Penk Gnao1 Adcy7 Prkar2a Prkaca Prkar2b Gnai2 Gnb1 Gnai3 Gnai1 Gnal ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Plcb3 Gna11 Plcb2 Adra2c Adra2b Plcb1 Adra1b Adra1a Plce1 Prkcg Prkcd Itpr1 Prkce Prkca Plcb4