ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis 29592 362843 64203 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway 362383 83688 64524 292804 25059 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation 29347 FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis 361472 24312 81522 680308 29261 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism 24191 24189 25659 24190 114860 298003 25059 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway 499497 287398 117045 81518 315994 81649 315305 311245 289014 60352 24471 689314 29513 114495 308463 314436 25435 314384 500526 25663 308106 313121 308267 501099 299618 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway 315994 81649 289014 24471 116590 310688 50689 83785 60664 24703 170897 313834 292658 84574 24600 314612 29560 360820 64363 315189 361632 289021 25023 293783 24653 25522 65052 293621 85420 170538 29340 24681 81749 84006 366957 298947 25513 29741 25738 29337 24680 85243 363875 366508 170851 58960 308589 24605 85421 311193 114486 25420 300115 24356 58918 24185 25614 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway 155140 29376 171060 309361 252963 317203 25647 25205 24499 24498 83571 114103 24497 114851 289014 25670 25084 286997 287287 25233 501560 314436 500526 501099 299618 116590 50689 24703 24600 64363 85243 24605 114486 24185 81771 58840 294515 84351 85385 81745 25467 56718 25124 116562 313845 25125 304786 29385 54258 84027 29414 314322 308716 288774 29197 367264 365769 116558 362871 366126 24493 116553 171334 25126 245983 171040 24918 304091 362896 117539 25325 499931 117269 246144 314711 25704 24577 25326 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis 501601 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis 304024 290868 25374 29421 361338 289352 289219 685245 25709 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway 24318 24668 293860 309557 59317 313052 304081 81636 24239 360616 25686 29553 84429 24400 25549 25636 29717 81721 25103 171131 54239 25102 25590 25101 25432 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system 29657 170917 299691 60447 287422 63840 58822 64462 78962 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis 29230 364764 310645 291211 83791 29580 81681 81726 29637 25675 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway 29628 29627 24406 84487 24412 59312 24411 29482 24410 25550 24409 24408 29483 266767 24407 29629 25012 83730 64630 116500 29528 25624 298521 54257 29559 685180 366432 24415 78957 84012 24803 292483 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis 293820 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle 64033 25193 299334 25729 296883 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 29741 140941 85243 366508 24605 81649 114851 60352 689314 29513 24185 25233 81745 60664 29414 25729 361632 300711 289021 362817 680111 24842 497931 84353 65052 246334 293621 362675 50557 24672 24673 24525 685055 25405 298947 24708 25513 116720 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis 498805 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation 81632 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway 25738 29337 85240 24680 29322 24654 83579 690825 114119 58979 79218 114117 294962 60449 81667 245986 25679 114120 81678 309242 25031 24655 24448 84587 140693 81666 114633 25262 497197 81662 24400 25023 25522 85420 170538 29340 24681 81749 84006 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway 24418 24414 266668 29559 501563 25636 24412 24411 25023 24410 24409 25031 24408 24407 81666 25262 81662 25521 293508 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response 116484 60661 499497 29467 287398 116554 303200 50658 24224 81649 24516 60352 689314 29513 24653 114495 314436 25435 500526 25124 24577 299618 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway 83579 690825 114119 58979 79218 114117 294962 60449 81667 245986 114120 293508 501563 81636 25686 29553 84429 24400 81664 64199 25636 84420 60448 24679 29699 25323 25075 24473 50664 25643 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway 25738 29337 85240 24680 29322 24654 83579 690825 114119 58979 79218 114117 294962 60449 81667 245986 114120 309242 25031 24655 84587 140693 81666 114633 497197 81662 24400 25023 25522 25342 85420 170538 29340 24681 81749 84006 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway 81636 83579 690825 114119 58979 79218 24400 114117 294962 60449 84420 81667 245986 114120 25324 24611 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling 64532 305509 25289 29241 690825 58979 79218 114117 294962 60449 81667 245986 25521 293508 81636 25686 24400 64199 25636 84420 29717 24679 29699 50664 25643 54223 83633 50599 25398 81657 257648 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway 295704 361831 81816 79435 81920 641452 296368 361013 360847 308384 308508 301000 314432 295686 298317 312647 289623 363836 116725 287927 117553 292588 305268 294331 64631 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway 24881 64512 282582 116777 89787 83469 679869 303586 287357 289820 315294 116466 140584 83721 83616 192183 312451 316527 303470 83502 303811 498013 294732 29437 84426 362268 117026 81679 25406 305338 282822 161452 25496 81822 29492 56761 406162 288227 29192 81751 54226 292788 300802 29392 289231 192218 89821 140933 84027 84494 299858 29216 89823 500047 26955 317674 29275 287876 25365 79210 312781 24882 58868 293649 114487 303181 64558 84353 316526 64566 315196 364754 266608 114850 282581 293990 291678 59323 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation 298079 29253 25750 299699 116676 685750 361571 266603 64040 65183 291450 24188 29539 29408 25375 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 24842 246334 362675 314856 304798 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis 29592 362843 64203 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization 314800 296259 311569 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis 171053 294088 360639 360511 METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle 50655 64831 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation 309361 81649 60352 25679 689314 29513 81678 25262 116590 50689 24703 116554 50658 24516 64363 25023 293621 170538 366957 298947 29337 25272 85243 295378 363875 116689 366508 81515 170851 296603 58960 171492 24699 24605 303604 25156 25155 361794 499356 367901 81504 681236 365367 171055 308501 24674 24675 84351 25493 313845 314322 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation 58845 83840 29414 24185 25233 24842 246334 362675 116636 24855 24672 24673 25520 65248 60445 78975 83803 64562 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis 24539 85240 85311 29322 309207 24654 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism 501167 363145 300089 302915 300741 291095 MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing 313056 361995 292729 362223 302670 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation 116484 29414 29560 308913 25242 24874 24185 25233 54244 368158 79462 54702 308457 56718 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism 680668 305889 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor 373541 309638 361365 500131 306542 499766 366856 299347 288533 170915 316711 81673 83828 307485 83830 681193 171152 295324 690966 140938 117526 680050 314638 362165 362339 310616 316216 170844 361580 81674 25521 316123 306516 303918 24679 29699 54244 83503 498109 689030 294236 288651 361420 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway 24613 24664 81636 83579 690825 25686 114119 58979 79218 24400 114117 81664 294962 60449 84420 81667 245986 114120 50664 25643 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation 361523 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis 306164 297417 360518 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis 24221 25504 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion 24399 316304 UNTITLED%PANTHER PATHWAY%P00019 untitled 85240 29322 24654 25679 81678 25233 309242 25031 81666 25262 81662 25521 116590 293508 50689 24703 81636 24600 24324 24323 59320 64363 25636 50672 84420 66012 64508 24679 29699 25023 25202 497757 24653 25523 25522 24326 366270 85420 170538 29340 24611 54223 24681 81749 84006 64532 305509 25289 24680 29241 170851 58960 24185 29414 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis 24443 TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis 29244 24312 29261 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway 25738 29337 85240 24680 29322 24654 83579 690825 114119 58979 79218 114117 294962 60449 81667 245986 114120 309242 25031 24655 84587 140693 81666 114633 497197 81662 24400 64199 25023 25522 85420 170538 25187 29340 29581 24681 29595 81749 84006 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway 685004 64350 25021 295588 362993 298859 360606 311144 315346 81008 25724 501132 361568 50646 296456 308995 24511 314981 25414 25713 25683 361821 294337 294732 361517 25150 360854 54227 288669 311716 301511 311061 313494 293860 499431 81822 307459 294279 25654 499271 83805 81824 309684 294027 25272 171492 303604 287398 29513 308106 50689 60664 24703 116554 303200 50658 360820 64363 361632 289021 65052 293621 366474 298069 685269 366957 361251 298947 314961 25513 363265 29741 306628 290905 84032 25412 85243 287942 363875 54245 366508 170922 170851 84352 58960 311862 309081 24605 362800 305679 25404 114486 170923 305104 313592 304021 85250 315707 25614 85490 309368 58840 363457 307582 85385 364786 63836 310683 361303 81634 291245 117255 313845 25473 305078 117036 362973 316758 192362 688429 362584 309816 140433 298941 315744 295347 498564 287876 171337 306204 64187 246310 303553 362271 64310 170568 57341 114517 25118 170921 79121 117273 25661 298101 64373 60379 295342 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway 309361 317203 286997 25233 501560 307459 25676 300955 25266 24628 25267 24629 363616 363735 295635 290771 316369 79434 500943 315532 502916 500287 362893 366962 361944 85424 50686 312108 304815 311529 307016 170909 292721 25272 246249 295378 299012 289342 366142 296603 302811 171492 295297 689210 295965 25156 84598 246271 81817 299117 140934 81504 84477 25597 361388 114858 207122 24514 314903 83840 497931 289014 25679 81678 314436 314384 500526 308106 25262 501099 299618 116590 50689 60664 24703 116554 314612 24516 64363 65052 293621 298947 25513 29741 25738 29337 24680 85243 366508 170851 58960 24605 311193 114486 300115 24356 81771 58840 84351 85385 81745 25124 313845 25125 304786 84027 688429 314322 288774 367264 25126 24918 362896 117269 24577 25326 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway 311570 79433 24582 691644 24583 360543 29556 294732 29437 81822 81721 25103 171131 54239 25102 25590 25101 29557 252942 25745 308572 366069 85426 60422 50690 299509 65261 64574 497974 294010 310178 24261 295417 170945 79557 501699 29275 25485 287876 25484 25365 25017 25132 315840 266714 498834 171296 289785 314654 25753 315820 29422 54240 117057 192253 360634 65024 304551 498806 29605 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway 25126 24918 362896 24514 367264 84598 25124 25326 25125 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism 361253 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis 58835 304429 293820 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin 29741 25738 29337 85243 363875 366508 60630 114524 307989 361400 305897 362049 114523 311658 295382 25311 306534 361517 60664 361632 289021 497931 366957 298947 25513 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis 113918 29323 292902 25693 24898 282712 83511 25549 664630 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation 396527 574523 396551 84493 286989 24299 368066 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism 361253 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis 25331 171347 81522 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase 311570 79433 24582 691644 24583 360543 29556 294732 29437 360854 54227 288669 301511 81822 291081 81824 307483 65172 296078 288057 81762 29431 29433 29432 297518 498736 311450 29214 317189 64303 292756 81531 685936 291926 25537 246118 296554 366624 366957 29271 29332 117558 307351 79423 363875 29557 252942 25745 308572 366069 29275 287876 25365 498806 295342 29605 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade 29376 25151 24483 25718 24482 317203 24506 170851 24954 58960 60663 501560 81771 314436 314384 25467 313845 116590 50689 83840 24703 314322 303200 25676 117269 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway 24514 116465 360697 25712 84598 25124 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis 24311 24848 317675 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides 685679 317237 304944 311864 289801 499956 295620 83782 85269 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway 83579 690825 114119 58979 79218 114117 294962 60449 81667 245986 25521 293508 24418 24414 501563 25686 24400 81664 59320 25636 24679 29699 25643 25398 257648 29628 29627 24406 24412 24411 29482 24410 25550 24409 24408 29483 24407 65277 29629 24923 116638 25012 50688 83730 116470 64630 60590 116500 81672 29528 24419 25624 298521 24417 54257 54234 29559 366432 84012 24803 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway 116667 288753 25625 156767 309361 246775 304962 293694 266704 287398 116674 64026 64044 406169 315305 81647 306886 60371 25309 314756 311786 81736 25233 309452 364420 78971 116590 50689 116554 303200 50658 24224 24516 25023 85420 170538 29340 24681 81749 298947 25151 25272 24680 85243 366508 58918 24185 84351 25493 63879 116502 94193 29414 309165 314322 362100 83533 24887 54318 363855 25389 79255 315333 305584 246756 266610 311130 24835 24842 170920 361795 360640 64547 246097 25385 24888 54287 78963 25008 25402 114496 140926 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis 29592 64203 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway 116667 317203 287398 315994 81649 81647 289014 60352 689314 29513 114495 501560 314436 29622 304109 25096 25097 308106 81757 116546 289080 501099 171455 116590 50689 24703 116554 303200 50658 24516 29431 64363 29433 29432 65052 293621 366957 50686 298947 25272 85243 363875 366508 170851 58960 24605 114486 81504 24356 24185 81771 85385 81745 25124 313845 25125 84027 29414 363855 117273 117269 24525 64373 295342 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin 85240 24680 29322 24654 83579 170851 690825 58960 114119 58979 114117 294962 60449 81667 245986 25679 81678 314436 81666 25262 25238 116590 25372 24330 50689 24179 24180 25387 24703 25388 24400 64199 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation 373541 309638 361365 306542 499766 366856 299347 288533 316711 81673 83828 307485 83830 171152 316216 170844 361580 81674 316123 306516 303918 83503 498109 689030 294236 288651 361420 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway 170915 114851 311786 24185 25233 81745 29414 309757 25163 313017 54237 680054 499417 690244 300126 299626 25112 25729 297893 300711 363067 362817 25203 291005 24842 307511 54244 361724 114212 246334 315713 362675 314856 50557 304798 685055 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway 85240 29322 24654 83579 690825 114119 58979 79218 114117 294962 60449 81667 245986 114120 309242 25031 24655 84587 140693 81666 114633 497197 81662 24400 25023 25522 116600 85420 170538 81802 29340 25569 24681 25570 81749 25653 84006 116700 25398 25297 58942 257648 25738 29337 24680 25012 50688 83730 64630 116500 29528 25624 54234 24803 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis 79243 117182 25055 25322 286964 25147 266770 29540 81782 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway 24881 64512 282582 116777 679869 303586 287357 289820 315294 116466 140584 312451 316527 83502 294732 29437 84426 161452 81822 307481 116782 360942 24697 307486 548105 191571 291646 680203 361943 291645 548106 307487 300128 307489 291654 291656 364844 394223 116779 116778 498843 393092 393091 295027 116742 93662 116781 393089 393088 393087 114028 311163 116741 116780 393086 291649 393085 83501 363948 317183 317204 301887 29181 29163 84408 84353 29162 25409 364841 307618 498850 311710 84407 291002 64865 306091 65048 83720 310174 117048 307614 361432 192248 114102 306081 498515 690865 301737 116808 252897 498849 680470 680361 364843 291635 502156 548104 360835 291637 83465 83466 498847 498846 553129 500047 317674 29275 287876 25365 79210 24882 58868 114487 303181 64558 316526 64566 315196 364754 266608 114850 282581 293990 291678 UNTITLED%PANTHER PATHWAY%P06664 untitled 309165 114208 316742 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation 65029 29473 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle 24368 360975 81530 114597 79250 685778 24551 117098 289217 170587 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis 171374 116550 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation 58961 24609 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion 361465 24624 301276 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis 305348 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism 81656 81632 116593 81708 25418 65208 58813 25416 65135 362638 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation 501157 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway 501563 81636 83579 690825 114119 58979 79218 24400 114117 294962 25636 60449 84420 81667 245986 24679 114120 29699 24611 24925 293508 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade 29376 25151 24483 84027 25718 24482 24506 24954 60663 294515 314856 50557 24855 304798 81745 25467 60445 50686 84482 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway 501563 81636 83579 690825 114119 58979 79218 24400 114117 294962 25636 60449 84420 81667 245986 24679 114120 29699 24611 25461 293508 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway 81636 83579 690825 114119 58979 79218 24400 114117 294962 60449 84420 81667 245986 114120 24611 25645 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism 83585 25095 497811 58813 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis 81522 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway 24664 64680 58959 81648 83579 690825 114119 58979 79218 24400 114117 294962 60449 81667 245986 114120 309242 24611 81666 81662 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway 25272 24680 54268 83589 83610 29716 114493 81649 316226 83611 29355 309159 60352 171549 286997 171041 689314 57027 29513 58840 207122 50688 292788 300802 116590 29392 289231 50689 192218 288227 24239 29192 116554 81751 54226 50658 25023 25522 116600 85420 170538 29340 24681 81749 84006 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis 24250 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo 363875 114524 114523 295382 60628 25311 58946 360272 311860 314903 83467 65047 24772 366957 295342 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis 685679 191575 83782 497840 24240 315615 313560 65156 85269 619580 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway 287398 81649 361568 60352 689314 29513 25233 114495 308106 116590 50689 24703 313834 116554 292658 303200 25676 50658 314612 64363 361632 363616 289021 25023 25522 65052 293621 85420 170538 29340 24681 81749 84006 366957 298947 25738 29337 25272 24680 85243 363875 366508 170851 58960 171492 24605 303604 85421 114486 84477 25597 24185 361388 114858 85385 25124 313845 25125 685611 25482 24329 29414 29496 24337 192126 288774 304893 291610 367264 306141 363855 24592 294981 365355 29542 691997 25126 497931 24918 362896 59323 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade 24367 24617 60325 287527 171052 361969 300339 81687 25692 25619 85253 171045 24366 PNAT%PANTHER PATHWAY%P05912 PNAT 25195 114117 294962 60449 81667 245986 24898 25012 83730 64630 116500 24318 29528 24668 293508 25624 293860 309557 59317 313052 501563 304081 81636 360616 25686 24803 29553 84429 24400 81664 25549 64199 25636 84420 24679 29699 25643 25432 81802 24316 25740 116724 24669 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway 361765 301516 89830 54244 140589 25273 303024 361769 29499 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway 83579 690825 114119 58979 365901 79218 29713 114117 25743 294962 116560 60449 363143 81667 25111 245986 81645 85426 25521 60422 293508 50690 501563 25686 24400 81664 59320 64199 25636 24679 29699 50664 25643 50599 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism 304860 302972 289608 297417 360518 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway 170915 81649 361568 81647 60352 689314 29513 24517 24518 500245 83711 680931 29373 498299 25667 313588 313121 25296 114208 315824 25644 116590 85272 81507 50689 29455 140590 59302 25671 500311 29357 116554 25631 50554 50658 59304 29152 64549 24516 290921 25196 294503 29200 29530 64466 289316 25717 29591 81810 293621 114490 303614 252834 245921 59328 367100 81516 85435 81809 25453 252833 500305 79216 25272 79558 29381 29263 25366 25237 300054 25445 24605 690516 365460 29454 83470 54244 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation 116669 29436 83580 289055 306761 116727 691992 25087 29243 24946 302470 171154 306608 25268 502858 81750 25259 25439 362248 260320 25584 25048 29251 24367 361969 25692 25619 85253 24366 685269 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway 29741 85243 83579 690825 24954 365901 24605 294962 60449 81667 58918 24185 25233 309242 294515 81745 81666 25467 81662 313845 83840 60664 84027 29414 680149 25637 302415 25686 25578 24600 24400 81664 497931 25643 84482 25513 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway 25195 29713 25743 116560 25111 81645 24318 81636 25686 24400 25636 25432 50686 680149 24415 140671 25033 171044 54305 65032 64354 25689 29353 54241 116561 83800 54244 81668 25354 25555 117097 29290 25369 29316 29335 25739 29256 64035 24701 24260 25370 25229 500131 29413 298400 53949 25623 690825 690987 114119 170704 170915 58979 114211 79218 192646 114117 64561 678739 361377 81667 85268 245986 24174 24175 114120 24173 29412 25601 81646 24176 24448 314638 362165 362339 310616 25521 293508 24418 24414 24613 81664 84420 60448 24679 64508 29699 25323 25075 24473 25643 25187 25324 29581 24611 29595 54223 50599 24925 25461 25645 64532 305509 25289 29241 60590 81672 24419 24417 84027 295347 171337 24316 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway 287398 81649 60352 689314 29513 25233 114495 79114 316213 313022 25114 25022 308106 84489 314850 116590 50689 24703 116554 303200 25676 50658 64363 361632 363616 289021 25023 25522 65052 293621 85420 170538 29340 24681 81749 84006 366957 298947 25738 29337 25272 24680 85243 363875 116689 366508 170851 58960 171492 24605 303604 25597 24185 114858 85385 313845 29414 291610 306141 363855 294981 29542 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis 25698 497840 24240 59085 25611 303563 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction 83579 690825 114119 58979 79218 114117 294962 363143 81667 245986 114120 685451 24717 81760 307401 680149 85257 85259 83686 307100 500418 140936 25343 24400 29481 289878 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis 29592 64203 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease 56011 117515 29668 25272 29669 29670 29671 29672 252939 81728 293507 117549 81649 60352 286997 314436 25097 24898 116590 50689 313017 116554 25578 50658 29219 25729 291983 116728 25085 29676 362485 56010 29753 85492 25576 65033 29647 56816 60466 29673 307309 29674 94198 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway 24260 25229 24680 83579 690825 114119 58979 79218 114117 294962 60449 29355 24412 81667 245986 24411 25679 24410 81678 309242 24409 25031 24408 207122 81666 25262 85426 81662 60422 24400 64199 25023 25522 85420 170538 29340 24681 81749 84006 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway 24613 81636 83579 690825 25686 114119 58979 79218 24400 29190 114117 81664 29237 294962 60449 84420 81667 245986 114120 25643 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication 59102 360243 25737 89809 116468 288414 680511 64550 309762 117056 288003 59294 304528 289758 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway 293829 24624 301276 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis 303179 191575 315150 289276 362720 365320 117544 299976 24184 301115 29223 295088 288259 58964 311833 85269 685679 83782 26956 315615 171566 81643 301005 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway 24384 289055 24705 25271 24873 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway 24260 25195 25370 25229 85240 29322 24654 53949 298859 690825 114119 58979 79218 114117 294962 60449 81667 25111 245986 81645 25679 114120 81678 25601 309242 25031 81666 25262 81662 24318 24418 24613 685451 24414 24400 25023 25522 50664 25432 85420 170538 29340 24681 81749 84006 25398 257648 24680 60590 81672 24419 24417 54234 680149 24415 25033 171044 295347 54305 171337 54241 116561 361714 83800 301372 81668 170668 25354 81509 25555 25245 29434 29290 313874 25369 313644 29316 117273 60323 29335 24316 29256 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis 25317 116667 24881 29146 64512 114125 282582 306760 114587 29210 79257 679869 691905 287989 79429 313633 315294 24338 116466 363595 299611 83721 691813 29147 89804 316527 89807 311332 25233 24205 303811 306636 25186 25096 25097 362268 25496 29492 406162 83805 25676 300955 25266 24628 25267 24629 363616 316369 84598 25439 84353 287398 315994 81649 289014 24471 79114 316213 314850 116590 310688 50689 83785 60664 24703 170897 313834 292658 116554 84574 24600 314612 29560 24516 360820 29431 64363 29433 315189 29432 361632 289021 25023 293783 24653 25522 65052 293621 85420 170538 29340 24681 81749 84006 298947 25513 29741 25738 29337 24680 85243 287942 54245 366508 170851 58960 308589 24605 85421 311193 114486 25420 300115 24356 58918 24185 25614 85385 25124 313845 25125 84027 29414 314322 317674 58868 114487 64566 315196 117273 290361 114850 84010 58844 64373 84427 312477 295342 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis 685679 191575 362720 365320 301622 299976 83782 315615 85269 29261 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking 25130 286931 59267 306285 25731 24805 192177 25531 64830 24923 25012 25558 25716 116470 60568 60565 191595 25624 54309 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 81647 50646 296456 24511 25414 501560 83502 24330 25388 83805 246215 116490 25622 309168 79222 24400 29304 25549 24598 25636 24854 25298 25706 361882 50659 363854 25050 84382 114124 686059 29568 292887 367846 25668 84582 24790 24884 29527 25664 294235 64639 25320 25272 25433 81515 81504 24674 24514 25493 116636 83840 84353 499497 287398 117045 81518 81649 311245 24471 311658 114495 81646 314436 25262 501099 293508 116590 50689 24703 292658 116554 50658 24224 81762 24516 360820 29431 64363 24609 25023 24653 85420 170538 29340 81749 84482 25513 56011 25738 305509 24680 85243 363875 54245 170851 58960 85421 114486 24185 25614 81771 294515 85385 81745 25467 313845 25125 304786 84027 314322 24887 360640 25619 24888 117273 171045 25402 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis 24189 296973 25630 24644 498731 25741 65152 24959 24333 24334 500983 24651 292804 25059 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway 25496 29146 29492 114125 56761 114587 406162 29419 29147 362149 303101 360801 311332 362268 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis 81632 24380 24379 60356 291133 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway 25272 287398 64026 64044 58918 299625 84359 298975 140657 83584 300985 290027 60374 116685 25591 361046 297339 117279 296654 116554 50658 24516 266610 246097 25385 78963 25402 140926 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway 309361 501132 361568 50646 308995 24511 314981 25233 309452 25713 24517 24518 25683 361821 294337 294732 29437 360854 54227 288669 311716 301511 81822 81636 81824 25686 25636 363616 25156 116669 24514 29557 252942 25745 308572 366069 308875 171056 282832 360918 316019 292413 292409 288264 307820 245920 116637 81780 287561 24770 29397 311647 114098 287562 301086 25542 363682 29538 24525 298006 60463 117551 57301 498806 84475 29605 29363 311570 89808 79433 301066 24582 85240 287673 691644 29322 308163 24583 24654 117029 360543 171054 29556 117027 114119 25400 58979 24246 79218 114117 60449 361400 305897 245986 25679 114120 311658 81678 309242 25031 24655 84587 140693 81666 114633 25262 497197 81662 293508 116590 50689 501563 24703 296078 288057 81762 24516 81664 29431 64363 29433 29432 297518 25023 311450 25522 50664 292756 25643 291926 29340 29647 366957 298947 117558 64532 25738 29337 25289 85243 363875 366508 24605 25712 24185 60628 84351 85385 81745 116562 313845 25125 29385 54258 29414 309165 29275 287876 25365 117273 295342 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway 83585 291355 290029 24465 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease 287398 170915 289820 64044 501132 58945 293539 65209 192154 360654 29495 29430 308463 308476 117526 252902 29167 294732 116694 29437 679870 85428 360854 294854 54227 29153 29154 29155 29156 83685 207117 300078 81822 81917 116659 29564 303968 291081 299145 81824 29489 300047 308578 50658 81637 81655 24516 171495 84009 29424 66020 140734 498736 408218 308666 29214 306260 24225 246118 296554 24790 366957 307351 363875 24406 500983 24412 24411 24410 24409 24408 24407 298521 54257 29559 314322 308875 363855 29275 287876 25365 116561 24842 54244 246334 362675 78963 25402 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation 246758 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism 25630 685778 25104 117098 24159 24552 170587 306198 362282 24651 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation 116667 309361 25233 25262 116590 50689 60664 24703 116554 50658 300955 24516 29431 64363 29433 29432 316369 65052 293621 85420 366962 171378 81511 25710 315609 298947 300678 25513 25300 29741 155918 25738 301348 313050 25660 85243 295378 25408 363875 56822 366508 170851 296603 58960 24699 24605 25156 114486 24185 24674 24675 84351 25493 313845 29414 314322 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway 309361 301059 170851 363984 58960 680127 316241 292892 81649 361677 317468 311245 305355 252961 363520 305353 29260 364594 364867 310553 314436 116596 84351 299827 25493 300447 300177 313121 50689 116554 303200 50658 24516 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism 293820 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway 171107 363481 361765 365755 497961 297867 84578 362533 303024 299636 298019 25565 84424 295251 84577 294071 691857 25671 50554 24400 59328 58822 64462 84353 24672 24673 140941 85240 29322 24654 114119 58979 79218 114117 294962 60449 361400 81667 305897 245986 25679 114120 311658 81678 309242 25031 81666 25262 81662 685451 500047 317674 79210 312781 24882 58868 293649 114487 303181 64558 316526 64566 315196 364754 266608 114850 282581 293990 291678 24881 64512 282582 116777 679869 79257 303586 287357 315294 116466 140584 83721 312451 316527 83502 303811 84426 161452 25387 25388 297893 307481 116782 360942 307486 548105 191571 291646 680203 361943 291645 548106 307487 300128 24674 307489 24675 291654 291656 364844 394223 116779 116778 498843 393092 393091 295027 116742 93662 116781 393089 393088 393087 116741 116780 393086 291649 393085 83501 363948 317183 317204 301887 29181 54244 29163 84408 29162 25409 364841 307618 498850 311710 84407 291002 64865 306091 65048 83720 310174 117048 307614 361432 192248 114102 306081 170915 498515 690865 116808 252897 498849 680470 680361 364843 291635 502156 548104 360835 291637 83465 83466 498847 498846 553129 25023 25522 85420 170538 29340 24681 81749 171378 84006 24680 361745 317575 171379 295568 140593 301020 361825 81650 307641 84027 287102 302711 64823 65278 113927 500430 304569 307505 297357 310707 307766 316477 500666 25539 685179 83833 363002 303518 296732 296084 361652 312754 309179 691318 363193 299147 114107 29748 29749 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway 292072 497811 291355 290029 24465 24165 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism 24538 25330 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway 83579 690825 114119 58979 365901 79218 114117 294962 60449 81667 245986 24923 25012 83730 50688 64630 116470 116500 25521 29528 293508 25624 54234 501563 24415 25686 24803 24400 81664 59320 64199 25636 24679 29699 50664 25643 25398 257648 UNTITLED%PANTHER PATHWAY%P05916 untitled 81636 83579 24221 690825 25504 25686 114119 58979 79218 24400 29190 114117 81664 294962 60449 84420 81667 245986 114120 50664 25643 29335 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins 363875 29431 306790 79209 246331 316009 65208 25417 25416 29751 25150 65135 361597 117273 60323 140908 25415 366957 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling 24418 24414 85240 29322 24654 690825 25686 58979 79218 24400 114117 294962 64199 60449 29717 81667 245986 50664 25643 25248 25398 257648 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I 287710 304714 83582 499766 140938 117526 680050 316216 689030 690450 360893 361420 25574 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides 362638 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway 501563 81636 83579 690825 114119 58979 79218 24400 114117 294962 25636 60449 84420 81667 245986 24679 114120 29699 24176 24611 293508 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release 83579 690825 114119 58979 79218 29190 114117 29237 294962 60449 81667 245986 114120 25601 81646 293508 24613 501563 81636 25686 24400 81664 25636 84420 24679 29699 50664 25643 24611 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis 25612 ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway 85240 24680 29322 24654 24174 24175 24173 29412 25031 170538 29340 114633 24681 25262 81662