ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-HSA-1169091.2 Activation of NF-kappaB in B cells Psma4 Ikbkb Psma3 Psma6 Psma5 Psma2 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Malt1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Card11 Prkcb Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Bcl10 Psmd7 Psmd6 Nfkbib Nfkbie Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Cul1 Rel Chuk CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine Acsm1 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors Nr3c2 Nr3c1 Thrb Nr2c1 Vdr Sumo3 Nr1h2 Rora Ppara Esr1 Pparg Pias3 Pias4 Ar Rxra Hdac4 Ube2i Rara Pgr Nr5a1 Pias1 Nr4a2 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 96%5685942 HDR through Homologous Recombination (HRR) Topbp1 Rpa2 Rad17 Rbbp8 Rtel1 Brca2 Brca1 Xrcc3 Rad51ap1 Xrcc2 Rpa3 Polk Rad1 Atm Polh Pole Ubc Sem1 Kat5 Exo1 Eme1 Mus81 Nbn Gen1 Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Fignl1 Rfc1 Rfc2 Pold4 Pold3 Hus1 Atrip Brip1 Dna2 Pole3 Rad51c Rad51d Pole2 Blm Rad51b Chek1 Pole4 Rad9a Bard1 Rad9b Top3a Slx4 Wrn Mre11a Spidr Palb2 Rad51 Rad50 Firrm Rpa1 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C Anapc15 Plk1 Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdk1 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876384 Listeria monocytogenes entry into host cells Stam2 Sh3gl3 Src Sh3kbp1 Stam Ctnnb1 Eps15 Cbll1 Cbl Hgs Ctnnd1 Cdh1 Sh3gl1 Sh3gl2 Ubc Met SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 96%187687 Signalling to ERKs Frs2 Ngf Kidins220 Ralgds Map2k2 Rit1 Rit2 Nras Ntrk1 Map2k1 Rapgef1 Sos1 Crk Hras Mapk11 Shc3 Shc2 Shc1 Mapk1 Braf Mapk3 Crkl Ywhab Mapk12 Rap1a Mapkapk3 Mapk13 Mapkapk2 Mapk14 Rala Ralb DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle Arg1 Nags Asl Cps1 Nmral1 Ass1 Otc Slc25a15 HEME SIGNALING%REACTOME DATABASE ID RELEASE 96%9707616 Heme signaling Tlr4 Rora Ppara Rxra Ncor1 Atf2 Slc46a1 Helz2 Carm1 Nrip1 Ep300 Tbl1x Hmox1 Mef2d Clock Clec1b Bmal1 Crtc3 Hdac3 Crtc2 Rai1 Ncoa2 Ncoa1 Xpo1 Tbl1xr1 Smarcd3 Crtc1 Ncoa6 Hba-a1 Mafk Hbbt1 Npas2 Med1 Bach1 Nr1d1 Pgrmc2 Ppargc1a Nfe2l2 Ly96 Crebbp Mef2c Apoa1 Chd9 Sirt1 Apob DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 96%1168372 Downstream signaling events of B Cell Receptor (BCR) Fkbp1a Nfatc1 Nfatc3 Ppia Nfatc2 Rasgrp3 Rasgrp1 Ppp3r1 Ppp3ca Ppp3cb Psma4 Ikbkb Psma3 Psma6 Psma5 Psma2 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Malt1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Card11 Prkcb Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Bcl10 Psmd7 Psmd6 Nfkbib Nfkbie Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Cul1 Rel Chuk Nras Hras DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME%R-HSA-8862803.4 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Cast Prdx2 App Jun Golga2 Prdx1 Capn1 Capn2 Sod2 Cdk5r1 Bcl2l11 Ywhae Cdk5 Fasl Capns1 Capns2 Cdc25c Foxo3 Lmnb1 Cdc25b Cdc25a SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport Slc44a3 Slc5a7 Slc44a4 Slc44a5 Slc10a6 Slc44a1 Slc44a2 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 96%2644605 FBXW7 Mutants and NOTCH1 in Cancer Notch1 Rbx1 Skp1 Cul1 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373080 Class B 2 (Secretin family receptors) Ucn Sct Ihh Adm Adcyap1 Ramp1 Shh Wnt5a Wnt9a Iapp Wnt9b Ucn3 Fzd10 Wnt10a Crhr1 Wnt10b Crhbp Gipr Gip Calcrl Smo Glp1r Crh Pth1r Wnt8b Wnt8a Wnt16 Wnt11 Calcr Ghrhr Adgre5 Gng10 Pth Dhh Adgre1 Gcgr Pth2 Glp2r Wnt6 Vipr2 Calca Vipr1 Gng3 Gng2 Ptch2 Ptch1 Gng4 Wnt7b Gng7 Ghrh Wnt3a Gng8 Pth2r Wnt7a Wnt2 Pthlh Wnt1 Wnt4 Wnt3 Fzd1 Gngt1 Gngt2 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Gcg Adcyap1r1 Wnt2b Ramp3 Ramp2 Gnb2 Adm2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Vip Gng12 Gng13 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs Rasal3 Syngap1 Kbtbd7 Spred1 Spred3 Spred2 Rasa2 Rasa1 Rasa4 Rasa3 Nf1 Dab2ip Psma4 Cul3 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Nras Hras Rasal1 Rasal2 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%888568 GABA synthesis Gad1 Gad2 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation Arsb Gusb Hexa Hexb Idua Ncan Bgn Cspg5 Cspg4 Dcn Bcan Vcan Glb1 Hyal4 Hyal3 Ids Hyal1 Glb1l3 Glb1l2 DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Ccne1 Ccne2 Atrx Fzr1 Tfdp2 Tfdp1 Skp2 Rb1 Ccnd2 Ccnd3 Ccnd1 Cdk6 Cdk4 Cdk2 E2f1 E2f2 E2f3 Cdkn1a Daxx Cdkn1b Cdkn1c LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702596 lestaurtinib-resistant FLT3 mutants Flt3 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2500257 Resolution of Sister Chromatid Cohesion Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Cenpo Cenpn Cenpm Mis12 Nup133 Cenpl Zwilch Cenpk Cenpi Cenph Smc1a Cenpf Cenpe Firrm Plk1 Cdk1 Clasp1 Clasp2 Pafah1b1 Smc3 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Rad21 Kif2b Kif2c Dync1li2 Pmf1 Wapl Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Stag2 Stag1 Ppp2r1b Ppp2r1a Pds5b Pds5a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Xpo1 Nuf2 Ccnb2 Nup85 Cdca8 Incenp Cdca5 Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME%R-HSA-9927426.2 Developmental Lineage of Mammary Gland Alveolar Cells Prl DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 96%5423599 Diseases of Mismatch Repair (MMR) Msh6 Msh2 Msh3 Pms2 Mlh1 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 96%388479 Vasopressin-like receptors Oxtr Avpr1b Avpr1a Oxt Avp Avpr2 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 96%1483101 Synthesis of PS Ptdss1 Ptdss2 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 96%351906 Apoptotic cleavage of cell adhesion proteins Ctnnb1 Dsp Tjp1 Casp3 Pkp1 Dsg2 Cdh1 Dsg3 Dsg1a Tjp2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Rnmt Ercc3 Cdk7 Rngtt Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 96%2395516 Electron transport from NADPH to Ferredoxin Fdx1 Fdxr Fdx2 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9608290 Defective MUTYH substrate processing COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 96%388841 Costimulation by the CD28 family Jun Rbx1 Cul3 Ccnd1 Cdk4 Ppp2cb Ppp2ca Ppp2r1b Ppp2r1a Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Ppp2r5e Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rela Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 H2ac20 H2-Eb1 Trib3 Prkaa1 Prkaa2 Myc Akt3 Akt2 Akt1 Erlin2 Erlin1 Atf3 Jund Rpn2 Rpn1 Hif1a Tcf7l1 Tcf7l2 Lyn Mov10 Yes1 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 Ezh2 H2ax B3gnt3 Csnk2a2 Tead4 Suz12 Cd28 Nfkb2 Ash2l Rac1 Hist1h2bp Jak1 Fos Vav1 H2aj Os9 Pik3r5 Pik3r6 Pik3r1 Pik3r2 Yap1 Tnfrsf14 Ctla4 Cd3g Cd3e Cd3d Pak1 Sel1l Fosb Magt1 Pak3 Pak2 Brd4 H2bc9 H2bc7 H2bc8 Grap2 H2bc3 Mib2 Tead3 Tead2 Tead1 Stat3 Tmem258 Stat1 Map3k14 Rictor H2ab2 Map3k8 Rnf185 Mycn Derl3 Nek2 Derl2 Derl1 H2bu2 Cd86 Cd80 Stt3a Stt3b Spop Ctnnb1 Vcp Tcf7 Ostc Prkag3 Pik3cg Pik3cb Pik3cd Prkag1 Prkag2 Cops5 Pik3ca Wwtr1 Tusc3 Kmt2c Btla Hist2h2aa1 Erlec1 Prr5 Dad1 Ywhag Pdpk1 Epas1 Dpy30 Wdr5 Ddost Csnk2b Eed Them4 Cd274 Gsk3b Lck Irf1 Mlst8 Icosl Lef1 H2bc14 Ptpn6 Pdcd1 Rnf5 Mtor Cd4 Ptpn11 Fyn Csk H2bc21 Tnrc6c H2bc26 Rbbp5 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Pdcd1lg2 Mapkap1 Prkab2 Ep300 Prkab1 Nfe2l2 Crebbp TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome Taf4 Taf3 Taf2 Taf1 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Rnmt Ercc3 Cdk7 Rngtt Ell Nelfa Nelfb Nelfe Taf15 Ctdp1 Taf11 Taf13 Taf12 Ccnk Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Taf9 Ncbp2 Ncbp1 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Taf8 Eloa Taf7 Taf6 Eloc Taf5 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%190872 Transport of connexons to the plasma membrane Gja1 Gjb2 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding Pfdn6 Cct6a Pfdn5 Pfdn4 Tuba1b Tuba1a Pfdn2 Pfdn1 Tuba1c Gba1 Tubal3 Rgs9 Rgs6 Rgs7 Stat3 Cct3 Cct2 Skic2 Tubb2b Vbp1 Kif13a Tubb2a Fkbp9 Fbxw10 Actb Fbxw4 Fbxw5 Fbxw7 Fbxw9 Ccne1 Xrn2 Ccne2 Sphk1 Tcp1 Tuba4a Cct6b Fbxw2 Gna11 Gna15 Gna14 Tbcd Arl2 Tbcc Fbxo4 Gapdhs Tbcb Tbca Fbxo6 Tuba8 Lonp2 Arfgef2 Gnaq Tbce Pdcl Tuba3b Cct8 Cct7 Cct5 Cct4 Dcaf7 Csnk2b Wrap53 Tubb6 Tubb3 Trp53 Tubb1 Rgs11 Fbxl3 Fbxl5 Ap3m1 Gng10 Nop56 Tubb4b Tubb4a Gng3 Gng2 Gng4 Gng7 Gng8 Hdac3 Gngt1 Gngt2 Csnk2a2 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Kpna1 Aaas Nup214 Banf1 Nup210 Nup155 Nup153 Slc25a5 Psip1 Slc25a4 Hmga1 Nup85 Nup37 Sec13 Nup160 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 96%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components Anapc15 Mad2l1 Bub1b Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Bub3 Cdc23 Cdc20 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) Atrx Daxx E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 96%113507 E2F-enabled inhibition of pre-replication complex formation Orc5 Orc4 Orc6 Orc1 Mcm8 Orc3 Orc2 Cdk1 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 96%112303 Electric Transmission Across Gap Junctions Gjd2 Gjc1 Panx2 Panx1 INFLUENZA INFECTION%REACTOME DATABASE ID RELEASE 96%168255 Influenza Infection Nup133 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Kpna1 Aaas Nup214 Nup210 Nup155 Nup153 Slc25a5 Rps14 Rpl4 Rps16 Rps18 Rps19 Eif2ak2 Rpsa Rpl37 Rpl39 Rps10 Kpnb1 Rps11 Rpl7 Hsp90aa1 Ipo5 Rpl32 Rps9 Rps7 Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Mlkl Grsf1 Tgfb1 Rps25 Rps26 Kpna4 Kpna7 Rps21 Kpna3 Cpsf4 Rpl39l Isg15 Rps15a Dnajc3 Clta Parp1 Cltc Calr Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Hspa1a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Canx Rps3 Rps4x Pabpn1 Ran Nup37 Nup160 Nup43 Ranbp2 Nup107 Rps27 Xpo1 Nup85 Sec13 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 96%5633231 Defective ALG14 causes ALG14-CMS Alg14 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME%R-HSA-8939245.2 RUNX1 regulates transcription of genes involved in BCR signaling Blk Elf1 Elf2 Cbfb Pax5 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism Coasy Slc5a6 Pdzd11 Aasdhppt Enpp1 Enpp2 Enpp3 Pank3 Pank2 Pank4 Vnn1 Slc25a16 Vnn3 Ppcs Pank1 Fasn Dcakd Ppcdc Slc25a42 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides Slc15a1 Ctns Slc15a3 Slc15a4 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript Nup133 Nup37 Nup160 Nup43 Nxt1 Rnps1 Gle1 Ranbp2 Fyttd1 Srsf1 Thoc1 Thoc2 Nup93 Thoc3 Nup50 Nup35 Thoc5 Thoc6 Nup54 Pom121 Thoc7 Nup205 Srsf9 Ddx39a Nup188 Cdc40 Tpr Srsf7 Nup107 Rae1 Ndc1 Srsf6 Nup42 Srsf3 Magoh Nup62 Ddx39b Nup88 Srsf2 Srsf11 Aaas Srrm1 Nup214 Rbm8a Upf3b Nup210 Nup155 Zc3h11a Nup153 Slu7 Poldip3 Alyref Nxf1 Chtop Dhx38 U2af1l4 Nxf7 Eif4a3 Casc3 Magohb Nup85 Ncbp2 Ncbp1 Sec13 FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9832991 Formation of the posterior neural plate Tbx6 Pou3f1 Sox2 Zeb2 Sox1 Wnt3a Fgf8 Znf521 Gbx2 Otx2 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis Tsnax Prkra Ago4 Ago3 Dicer1 Ago2 Tarbp2 Ago1 Tsn TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels Trpc3 Trpa1 Trpv1 Trpv3 Mcoln1 Mcoln2 Trpv2 Trpc4ap Trpm2 Trpm1 Trpm8 Trpm7 Trpm4 Trpm3 Trpm6 Trpm5 Trpv5 Trpv4 Trpv6 Trpc6 Trpc5 Trpc7 Mcoln3 Trpc1 Trpc4 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells Fn1 Lama5 Vtn Lamb2 Lama1 Lamc3 Lamb3 Lama2 Lama3 Lama4 Lamc1 Lamb1 Lamc2 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME%R-HSA-164940.5 Nef mediated downregulation of MHC class I complex cell surface expression Ap1s3 Ap1s2 Ap1b1 Ap1s1 Ap1g1 B2m H2-Q10 Ap1m2 Ap1m1 Pacs1 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Kcnk1 Kcnk7 Kcnk6 PROTEASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9907900 Proteasome assembly Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psme4 Psmc5 Psme3 Psmc2 Psme2 Psmc1 Psme1 Psmc4 Psmd10 Psmc3 Psmb11 Psmb10 Pomp Psmd7 Psmf1 Psmd6 Psmg2 Psmg1 Psmg4 Psmd8 Psmg3 Psmd3 Psmb9 Psmd2 Psmb8 Psmd1 Psmd9 Psmd5 Adrm1 Psmd4 Sem1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation Rasgrp1 Psma4 Ikbkb Psma3 Psma6 Psma5 Psma2 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Malt1 Ube2d1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Card11 Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Bcl10 Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Pdpk1 Adrm1 Sem1 Traf6 Cul1 Ube2n Prkcq Chuk Rasgrp4 Rasgrp2 Cdc34 Ube2v1 Tab3 Tab2 Tab1 Lyn TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9856649.3 Transcriptional and post-translational regulation of MITF-M expression and activity Ywhae Ctnnb1 Cdh1 Mapk1 Mapk3 Ywhab Ywhag Gsk3b Ednrb Lars1 Tfeb Lef1 Mitf Eef1e1 Mark3 Ywhah Kars1 Hdac1 Tfec Ube2i Zic1 Sox9 Akt3 Edn1 Edn3 Tfe3 Pax3 Tnfsf11 Foxd3 Mc1r Rps6ka1 Mars1 Kit Wnt3a Mc5r Csf1 Ep300 Ywhaz Dars1 Hint1 Qars1 Rars1 Mc4r Pomc Id1 Alx3 Pou3f2 Sox10 Sox2 Aimp2 Xpo1 Aimp1 Eprs1 Snai2 Iars1 Tbx3 Mc3r Crebbp Sirt1 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209968 Thyroxine biosynthesis Duox1 Duoxa1 Duoxa2 Cav1 Dio1 Txndc11 Dio2 Dio3 Duox2 Tpo Iyd Cga Slc5a5 Tshb AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 96%9748787 Azathioprine ADME Tpmt Impdh1 Gmps Nme2 Hprt1 Nme1 Vav2 Abcc4 Gstm2 Guk1 Abcc5 Slc29a2 Slc28a3 Slc28a2 Slc29a1 Xdh Rac1 Vav1 Vav3 Nudt15 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle Cct6a Cul3 Dbn1 Spen Twf1 Pde5a Msi2 Tmod3 Cct2 Myo6 Txnl1 Ddx39b Phip Rbmx Actg1 Srrm1 Cops4 Tra2b Cops2 Stk38 Hsp90ab1 Cpsf7 Hnrnpc Actn1 Cdc37 Rhobtb2 Rock2 Rhobtb1 Rock1 Vim Rnf20 Hsp90aa1 Cct7 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA Mcm4 Mcm5 Mcm6 Cdc45 Mcm2 Mcm8 Gins2 Gins1 Mcm7 Gins4 Gins3 Mcm3 NGF PROCESSING%REACTOME DATABASE ID RELEASE 96%167060 NGF processing Ngf Furin Pcsk5 Pcsk6 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer Tgfb1 Tgfbr1 Tgfbr2 MTOR SIGNALLING%REACTOME%R-HSA-165159.9 MTOR signalling Strada Fkbp1a Pgk1 Slc38a9 Lamtor5 Akt1s1 Lamtor4 Rraga Mlst8 Rragb Eef2k Lamtor1 Rragc Lamtor2 Rragd Mtor Tsc2 Tsc1 Prkaa1 Stk11 Prkaa2 Eif4b Eif4e Akt3 Cab39l Akt2 Tnrc6c Akt1 Tnrc6a Tnrc6b Prkab2 Prkab1 Mov10 Ago4 Ago3 Ago2 Ago1 Prkag3 Prkag1 Prkag2 Ywhab Rptor Ppm1a Eif4ebp1 Eif4g1 Stradb Cab39 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 96%5579007 Defective ACY1 causes encephalopathy Acy1 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 96%168799 Clostridium neurotoxicity Stx1b Sv2c Syt2 Snap25 Sv2b Syt1 Sv2a Vamp1 Vamp2 Stx1a APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME%R-HSA-5467333.3 APC truncation mutants are not K63 polyubiquitinated Apc TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters Slc34a3 Slc34a2 Slc34a1 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME DATABASE ID RELEASE 96%5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) Ikbkg Ikbkb Chuk REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 96%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) Sp1 Cyp51a1 Elovl6 Dhcr7 Srebf2 Ran Fasn Ppara Rxra Helz2 Carm1 Tbl1x Fdft1 Insig1 Insig2 Ggps1 Sc5d Scd1 Sar1b Ncoa2 Lss Ncoa1 Tm7sf2 Tbl1xr1 Sec23a Pmvk Smarcd3 Mtf1 Scap Ncoa6 Mvd Acacb Acaca Fdps Med1 Idi1 Mvk Nfyb Nfya Nfyc Kpnb1 Sec24d Sec24c Mbtps1 Crebbp Mbtps2 Sec24b Chd9 Sqle Sec24a Gpam ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 96%451308 Activation of Ca-permeable Kainate Receptor Dlg1 Dlg3 Grik5 Dlg4 Grik2 Grik1 Grik4 Grik3 Ncald INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME DATABASE ID RELEASE 96%8875360 InlB-mediated entry of Listeria monocytogenes into host cell Stam2 Sh3gl3 Sh3kbp1 Stam Eps15 Cbl Hgs Sh3gl1 Sh3gl2 Ubc Met MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E Ubc REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5218859 Regulated Necrosis Mlkl Il18 Birc3 Birc2 Peli1 Chmp2a Tradd Traf2 Trp63 Sdcbp Prkn Xiap Fasl Chmp3 Tnfsf10 Chmp7 Chmp6 Irf2 Tnfrsf10b Fadd Ube2l3 Gzmb Flot2 Cdc37 Flot1 Elane Itch Ripk3 Chmp4c Chmp4b Bak1 Casp3 Casp8 Casp4 Casp1 Ripk1 Stub1 Ubc Gsdme Pdcd6ip Gsdmd Il1a Il1b Bax Fas Ogt Trp53 Irf1 Hsp90aa1 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 96%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) Slc22a5 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%8866376 Reelin signalling pathway Fyn Sh3kbp1 Reln Vldlr Dab1 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 96%8949613 Cristae formation Atp5f1d Atp5pb Atp5f1c Atp5pf Apool Mtx1 Mtx2 Tmem11 Atp5mc3 Apoo Atp5mf Hspa9 Atp5me Dmac2l Atp5f1b Atp5f1a Dnajc11 Atp5mk Micos10 Micos13 Chchd6 Samm50 Chchd3 ATP6 Immt RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-HSA-110314.5 Recognition of DNA damage by PCNA-containing replication complex Rpa2 Rpa3 Pole Ddb1 Wdr48 Ube2b Usp1 Cul4a Rad18 Cul4b Dtl Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Rfc1 Rfc2 Pold4 Pold3 Rbx1 Pole3 Pole2 Ubc Pole4 Rpa1 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%5578775 Ion homeostasis Prkaca Stim1 Tnni3 Kcnj11 Abcc9 Itpr3 Itpr2 Itpr1 Ryr2 Fkbp1b Ryr1 Atp2a1 Dmpk Atp1a2 Fxyd4 Atp1a1 Atp2a3 Fxyd1 Atp2a2 Atp1a3 Fxyd7 Sri Fxyd6 Trdn Camk2g Ryr3 Camk2d Ahcyl1 Camk2b Asph Camk2a Nos1 Slc8a1 Slc8a2 Atp1b1 Slc8a3 Atp1b3 Atp2b2 Atp1b2 Atp2b1 Atp2b4 Atp2b3 Trpc1 Orai1 Orai2 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects Anapc15 Fzr1 Skp2 Rb1 Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559583 Cellular Senescence Sp1 Jun Nfkb1 Lmnb1 Rela Ubc Il1a Trp53 H2ac20 Kat5 Rps6ka1 Nbn Mov10 H2ac12 H2ac11 Hmga1 Ago4 Ago3 Id1 Ago1 H2ac15 H3c7 Ezh2 H2ax Suz12 Hist1h2bp Fos H2aj Mre11a Rad50 Mapk9 Mapk7 Mapk8 H2bc9 Ets1 H2bc7 Map3k5 H2bc8 Ets2 Atm Tinf2 H2bc3 H1f2 H1f3 Tnik Anapc5 Cdkn2a Anapc4 Cdkn2b Anapc1 Stat3 Cdkn2c Anapc2 Hira Anapc11 Ube2c Ehmt2 Erf Anapc10 H2ab2 Ehmt1 Anapc7 H3c8 Cdc27 Txn Ube2d1 Map4k4 Kdm6b Cdc16 Cabin1 Anapc16 Il6 Ube2e1 Cdc23 Ring1 H2bu2 Cbx8 Anapc15 Phc2 Ccne1 Cbx6 Ccne2 Phc1 Acd Cbx4 Fzr1 Cbx2 Tfdp2 H1-1 Tfdp1 H1-0 Asf1a Rb1 Phc3 Terf2ip H1-5 H1-4 Cdk6 Cdk4 Mdm2 Cdk2 Hmga2 Mdm4 E2f1 Ccna1 E2f2 Ccna2 E2f3 Mapk1 Terf2 Cdkn1a Terf1 Mapk3 Hist2h2aa1 Ep400 Cdkn1b Bmi1 Ifnb1 Igfbp7 Rps6ka3 Mink1 Mapkapk3 Rps6ka2 Pot1 Mapkapk2 Map2k7 Mapk14 Cebpb Map2k6 Eed Rnf2 Ubn1 Mapkapk5 Map2k4 Map2k3 Mapk10 H2bc14 Mapk11 H2bc21 Tnrc6c H2bc26 Rbbp4 Rbbp7 Tnrc6a Tnrc6b DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Ccne1 Ccne2 Tfdp2 Tfdp1 Rb1 Ccnd2 Ccnd3 Ccnd1 Cdk6 Cdk4 Cdk2 E2f1 E2f2 E2f3 Cdkn1a Cdkn1b Cdkn1c SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 96%9006115 Signaling by NTRK2 (TRKB) Frs2 Src Tiam1 Bdnf Nras Gab1 Plcg1 Frs3 Ntf4 Sos1 Ntrk2 Dock3 Hras Ntf3 Ptpn11 Grin2b Pik3ca Rac1 Cdk5r1 Cdk5 Pik3r1 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes Sp1 Egf Mafk Bcl2 Pdgfa Bcl2l1 Areg Notch1 Nfe2l2 Crebbp Ep300 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Eef1a2 Eef1d Eef1g Rps27l Eef1b Rplp2 Rps27 Eef2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) Akt3 Akt2 Akt1 Tsc2 Tsc1 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2691230.3 Signaling by NOTCH1 HD Domain Mutants in Cancer Neurl1a Dll1 Mib1 Notch1 Dll4 Jag2 Jag1 Adam10 Neurl1b Ubc Mib2 Adam17 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%389357 CD28 dependent PI3K Akt signaling Them4 Lck Mlst8 Mtor Trib3 Fyn Akt3 Akt2 Akt1 Map3k14 Rictor Map3k8 Mapkap1 Cd86 Cd80 Pik3cg Pik3cb Pik3cd Cd28 Pik3ca Prr5 Pik3r5 Pdpk1 Pik3r6 Pik3r1 Pik3r2 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 96%191859 snRNP Assembly Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Gemin7 Gemin4 Gemin5 Snrpb Prmt5 Smn1 Snupn Snrpd2 Snrpd1 Nup85 Clns1a Phax Snrpd3 Gemin2 Ncbp2 Ddx20 Ncbp1 Wdr77 Nup37 Sec13 Nup160 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives Alox5 Ptgs2 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels Kcnj11 Abcc8 Abcc9 Kcnj8 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 96%174577 Activation of C3 and C5 C3 C4a C5 Cfb C2 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion Pnliprp2 Pnliprp1 Pnlip Gucy2c Lipf Pir Amy2a5 Amy1 Alpi Guca2b Sis Guca2a Lct Chia Chit1 Mgam Treh Cel Clps RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP Eif2b5 Eif2b4 Eif2s3x Eif2b1 Eif2s2 Eif2s1 Eif2b3 Eif2b2 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69580.5 p53-Dependent G1 S DNA damage checkpoint Psma4 Atm Psma3 Psma6 Psma5 Psma2 Psma1 Cdkn2a Psmd12 Psmd11 Phf20 Psmd14 Pcbp4 Psmd13 Chek2 Zfp385a Cop1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Ccne1 Psmb2 Ccne2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Mdm2 Ubc Cdk2 Mdm4 Ccna1 Psmd7 Ccna2 Psmd6 Cdkn1a Psmd8 Cdkn1b Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Trp53 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 96%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) Slc35a3 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity Mafk Bach1 Skp2 Rbx1 Skp1 Fbxl17 Cul1 Ubc SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids Slc43a1 Slc43a2 Slc7a11 Slc7a10 Slc1a1 Slc25a29 Slc3a1 Slc38a5 Slc1a3 Slc38a4 Slc1a2 Slc1a5 Slc38a3 Slc38a2 Slc36a4 Slc1a4 Slc3a2 Slc1a7 Slc1a6 Slc7a3 Slc7a1 Slc6a6 Slc6a19 Slc7a6 Slc7a7 Slc7a5 Slc6a15 Slc38a1 Slc6a14 Slc36a2 Slc7a8 Slc36a1 Slc7a9 Slc6a12 Slc6a20a MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein Ganab Mgat5 Zdhhc9 Man2a1 Zdhhc11 Mgat2 Mgat1 Magt1 Mogs Golga7 Edem2 Fut8 St6galnac3 St6galnac4 St6galnac2 St3gal4 Mgat4c Mgat4a St3gal2 Mgat4b St3gal1 Man1b1 Tmem258 Zdhhc20 Prkcsh St6gal1 Zdhhc8 Rpn2 Zdhhc5 Rpn1 Zdhhc3 Zdhhc2 Canx Stt3a Stt3b Ostc Tusc3 Dad1 Ddost NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 96%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission Actn2 Ppm1f Nefl Ppm1e Grin1 Dlg1 Grin2d Dlg3 Grin2c Dlg4 Camk2g Camk2d Grin2b Camk2b Camk2a Grin2a Camk4 Camk1 Dlg2 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response Furin Rhbdf2 Il10 Cd163 Plk2 Myh9 Mapk14 Il6 Adam17 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 96%168316 Assembly of Viral Components at the Budding Site Canx Calr ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%9645460 ALPK1 signaling pathway Tab3 Tab2 Map3k7 Tab1 Traf6 Tifa Alpk1 Ubc INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex Anapc15 Mad2l1 Bub1b Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Bub3 Cdc23 Cdc20 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway Nfatc2 Prdx2 Jun Prdx1 Sod2 Cdk5r1 Bcl2l11 Ywhae Cdk5 Fasl Cdc25c Foxo3 Notch1 Rbx1 Ihh Crh Gad1 Gad2 Ccne1 Ccne2 Fzr1 Tfdp2 Tfdp1 Skp2 Rb1 Ccnd2 Ccnd3 Ccnd1 Cdk6 Cdk4 Cdk2 E2f1 Cdkn1a Daxx Cdkn1b Ppp2cb Ppp2ca Ppp2r1b Ppp2r1a Birc5 Aurkb Ppp2r5c Msh2 Pms2 Mlh1 Tjp1 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 H2ac20 Prkaa1 Prkaa2 Myc Akt3 Akt2 Akt1 Tcf7l1 Tcf7l2 Mov10 Yes1 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 Ezh2 H2ax Csnk2a2 Tead4 Suz12 Ash2l Hist1h2bp Fos H2aj Yap1 Ctla4 H2bc9 H2bc7 H2bc8 H2bc3 Tead3 Tead2 Tead1 Stat1 Rictor H2ab2 H2bu2 Tcf7 Prkag3 Prkag1 Prkag2 Wwtr1 Kmt2c Hist2h2aa1 Prr5 Ywhag Pdpk1 Dpy30 Wdr5 Csnk2b Eed Gsk3b Mlst8 Lef1 H2bc14 Mtor Ptpn11 H2bc21 Tnrc6c H2bc26 Rbbp5 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Mapkap1 Prkab2 Prkab1 Ell Nelfa Nelfb Nelfe Taf15 Ctdp1 Taf11 Taf13 Taf12 Ccnk Tbp Taf4b Taf9 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Taf8 Eloa Taf7 Taf6 Eloc Taf5 Taf4 Taf3 Taf2 Taf1 Trp53 Tgfb1 Parp1 Blk Elf1 Elf2 Cbfb Pax5 Sox2 Znf521 Trpc3 Prkcq Ywhah Hdac1 Sox9 Kit Ywhaz Pomc Cav1 Cga Furin Rptor Ppm1a Slc38a9 Lamtor5 Lamtor4 Rraga Rragb Lamtor1 Rragc Lamtor2 Rragd Tsc2 Tsc1 Stk11 Nfyb Nfya Nfyc Gpam Sp1 Trp63 Tnfrsf10b Itch Casp1 Stub1 Bax Fas Camk2g Camk2d Camk2b Camk2a Prkaca Cdkn2a Cdkn2b Ehmt2 Ehmt1 Txn Il6 Ring1 Cbx8 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Mdm2 Mdm4 Ccna1 Ccna2 Bmi1 Cebpb Map2k6 Rnf2 Mapkapk5 Bdnf Grin2b Jag1 Dll1 Prmt5 Phf20 Pcbp4 Chek2 Zfp385a Grin2a Camk4 Plk2 Gamt Myl12a Erbb2 Gls Itgbl1 Myb Zfp839 Cldn5 Ddit4 Ddit3 Txnip Med8 Retn Med4 Med6 Lgals3 Zfp825 Axin1 Gata3 Gata4 Pip4k2b Gata1 Gata2 Pip4k2a Higd1c Cited4 Cited1 Cited2 Zfp819 Nfe2 Plk3 Cdc7 Cdk13 Cdk12 Abca6 mt-Co2 mt-Co3 Gatad2a Junb Gatad2b Ret Gpi Btg2 Btg1 Chm Zfp872 Gli3 Gli2 Ing5 Ing2 Rarb Zik1 Brd2 Ppard Zfp867 Zkscan16 Tal1 Wwox Gps2 Zfp616 Rybp Tcf12 Zfp612 Brd7 Zfp619 Pf4 Kat2b Rarg Fancd2 Kat2a Wwp1 Zfp605 Atad2 Zfp606 Atxn3 Socs3 Gprin1 Smyd2 Socs4 Trp53rkb Men1 Zfp30 Usp2 Zfp37 Usp7 Pvalb Gria2 Csf2 Zfp69 Sesn2 Coxfa4 Cnot11 Sesn3 Itga5 Tfap2c Tfap2d Csf1r Tfap2a Tfap2b Setd1b Steap3 Itga4 Setd1a Tfap2e Cnot10 Abl1 Brpf3 Brpf1 Npas4 Zfp51 Kat6a Cdk8 Bcl6 ZNF418 Znf354c Znf354b Zfp84 Sin3a Sin3b Tnks1bp1 Il2ra Itgal Lbr Zfp90 Zfp78 Gpx2 Hand2 Iqsec3 Skil Pink1 Gls2 Dgcr8 Ptpn4 Ptpn1 Cox7a1 Cox7a2 Rnf34 Atp1b4 Klf4 Pitx2 Pml Ins2 Nkx2-5 Zfp157 Zfp398 Cox7a2l Zfp141 Cnot6l Actl6a Actl6b Smarce1 Apaf1 Rffl Znf382 Cradd Pidd1 Havcr2 Rnf111 Znf394 Tpx2 Tmem219 Zfp369 Banp Esrra Fanci Pbrm1 Esrrb Esrrg Fancc Zfp180 Zfp189 Zfp184 Fkbp5 Sgk1 Ccng2 Znf2 Zfp175 Znf583 Npy Vegfa Satb2 Zfp169 Lifr Zfp791 Zfp790 Zfp317 Zfp558 Zfp799 Lmo2 Lmo1 Zfp300 Zfp786 Ube2d3 Znf569 Nop2 Arid2 Znf775 Zfp777 Nedd4l Yeats4 Fbxo32 Cbx5 Cbx3 Irak1 Znf551 Esr2 Zfhx3 Zfp764 Auts2 Jmy Ndrg1 Zfp111 Zfp597 Zfp113 Zfp112 Ybx1 Znf750 Tgif1 Tgif2 Ifng Kcnip3 Nr1d2 Kctd15 Mybl2 Znf771 Kdm5b Znf770 Rbl2 Itga2b Trim63 Dyrk2 Trp53inp1 Rbl1 Aurka Trim28 Zfp334 Hes1 Thra Zfp563 Dek Trim33 Zfp560 Zfp566 Zfp324 Prdm1 Mdc1 Spi1 Nampt Zfp712 Znf710 Zfp711 Twist2 Znf18 Twist1 Zfp703 Zfp709 Zfp706 Zfp708 Zfp707 Maml1 Maml2 Hdac11 Hdac10 Sfn Rbpj L3mbtl2 Zfp354a L3mbtl1 Znf704 Med23 Med24 Med25 Med20 Ddb2 Zscan25 Hey2 Hey1 Med26 Med27 Med12 Mmp13 Med13 Med14 Med10 Zfp740 Rspo3 Zfp746 Usp9x Med15 Med16 Krba1 Med17 Ncor2 Aifm2 Htt Zfp735 Pcgf6 Pcgf2 Pcgf5 Spp1 Bid Mbd3 Ucma Yy1 Ski Tigar Tnfrsf18 Hipk1 Hipk2 Srebf1 Mamld1 Cox6a1 Cox6a2 Rabggta Rabggtb Agrp Arid1a Arid1b Ppp1r13l Serpinb13 Kmt5a Egfr Ppp1r13b Maf Serpine1 Max Dlx5 Rgcc Sp7 Cpap Cnot3 Cnot2 Cnot1 Cnot7 Cnot6 Med30 Med31 Cnot4 Rorc Cnot9 Cnot8 Rorb G6pc1 Kmt2d Cox6b1 Cox6b2 Kmt2b Pin1 Trp53bp2 Rrm2b Syt10 Hivep3 Hdac2 Hdac5 Smarcb1 Foxg1 Slc2a3 Hdac7 Hdac6 Yaf2 Hdac9 Hdac8 Mobp Smarca2 Triap1 Smarca4 Nrbp1 Srf Arnt Prelid3a Smarcd1 G6pdx Smarcd2 Mga Pten Tbx5 Sst Smarcc2 Smarcc1 Nlrc4 Ppm1d E2f4 E2f5 E2f6 E2f7 E2f8 Uxt Rbfox1 Rbfox3 Epc1 Ccn2 Col1a2 Col1a1 Zfp2 Zfp1 Ccnc Zfp266 Zfpm1 Thbs1 Zfp9 Znf263 Pck1 Pip4p1 Cox8a Zfp248 Apoe Nuak1 Hnf4a Ctsk Ctsl Prmt6 Cox7b Prmt1 Hnf4g Psma4 Foxo4 Gp1ba Psma3 Bcl2l14 Psma6 Foxo1 Psma5 Zkscan8 Psma2 Tgfa Psma1 Zkscan1 Znf250 Zkscan4 Psmd12 Zkscan5 Psmd11 Znf496 Psmd14 Zkscan3 Psmd13 Bnip3l Nfkb1 Smurf2 Skp1 Smurf1 Foxp3 Psmb5 Nr4a3 Psmb4 Nr4a1 Psmb7 Zfp27 Psmb6 Zfp28 Psmb1 Runx3 Psmb3 Cox5a Psmb2 Zfp11 Zfp12 Zfp13 Rela Npm1 Prkcb Zfp14 Mstn Psma7 Zfp287 Psmc6 Zfp286 Psmc5 Ppargc1b Psmc2 Zfp282 Psmc1 Gck Psmc4 Ttc5 Psmc3 Kctd6 Ubc Nr2c2 Kctd1 Psmd7 Znf436 Psmd6 Zfp677 Pou4f1 Pou4f2 Psmd8 Msx2 Psmd3 Plxna4 Psmd2 Znf692 Psmd1 Gem Zfp426 Adrm1 Rxrb Sem1 Znf689 Cul1 Zfp664 Perp Oprm1 Sirt3 Trp73 Nr3c1 Rxrg Thrb Il2 Nr2c1 Zfp655 Vdr Smad1 Smad2 Nr1h2 Bmp2 Rora Smad3 Ppara Smad4 Esr1 Znf667 Pparg Nppa Znf668 Tcf3 Ar Smad6 Rxra Smad7 Hdac4 Ldb1 Ube2i mt-Co1 Rara Zfp473 Pgr Txnrd1 Nr5a1 Zfp235 Meaf6 Nr4a2 Cox4i1 Kat5 Cox4i2 Exo1 Hspd1 Nr2f6 Nr0b2 Nbn Nr2f1 Znf641 Rfc5 Notch4 Rbm14 Prelid1 Rfc3 Chd3 Pcna Chd4 Rfc4 Notch2 Cat Notch3 Rfc2 Nr2e1 Nkx3-2 Gadd45a Hus1 Zfp454 Atrip Zfp212 Brip1 Zfp691 Dna2 Igfbp3 Rest Zfp213 Rad51d Zfp697 Igfbp1 Blm Zfp458 Kras Chek1 Mta2 Rrm2 Rad9a Casp6 Bard1 Casp2 Rad9b Nr2c2ap Top3a Zfp445 Zfp202 Wrn Zfp688 Mre11a Zfp446 Oprk1 Rad51 Rad50 Rpa1 Topbp1 Rpa2 Rad17 Rbbp8 Brca1 Rpa3 Rad1 Atm Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdk1 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Src Ctnnb1 Met Mapk1 Mapk3 Ywhab Mapk14 Mapk11 Ncor1 Atf2 Carm1 Ep300 Tbl1x Bmal1 Hdac3 Xpo1 Tbl1xr1 Smarcd3 Med1 Nr1d1 Ppargc1a Crebbp Mef2c Sirt1 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF Arrb1 Jak2 Fgb Fga Rap1b Map2k2 Ksr1 Vwf Cnksr2 Nras Cnksr1 Fgg Map2k1 Araf Mark3 Itgb3 Pebp1 Raf1 Hras Tln1 Map3k11 Fn1 Vcl Csk Itga2b Src Camk2g Camk2d Camk2b Kras Camk2a Mapk1 Braf Mapk3 Ywhab Rap1a Brap Phb1 Apbb1ip Arrb2 Iqgap1 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins Hpgd Alox5 Lta4h XENOBIOTICS%REACTOME DATABASE ID RELEASE 96%211981 Xenobiotics Cyp2b10 Ahrr Cyp2c50 Cyp1a2 Cyp2a5 Cyp2w1 Cyp2s1 Ahr Cyp2d22 Cyp3a16 Cyp3a13 Cyp3a57 Cyp2c65 Cyp2c55 Cyp2j6 Cyp2f2 Arnt Cyp2e1 Cyp1a1 IRON UPTAKE AND TRANSPORT%REACTOME%R-HSA-917937.6 Iron uptake and transport Mcoln1 Skp1 Atp6v0b Hfe Atp6v0a2 Slc40a1 Atp6v0a4 Atp6v1g3 Cp Hmox2 Atp6v0e2 Atp6v0a1 Atp6v1c2 Ubc Atp6v1c1 Tf Ftl1 Glrx3 Fth1 Cybrd1 Cand1 Abcg2 Ftmt Tfr2 Atp6ap1 Atp6v1e2 Atp6v1e1 Cul1 Steap4 Slc22a17 Tcirg1 Slc11a2 Tfrc Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Fbxl5 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Ireb2 Heph Atp6v1f Atp6v1d Nedd8 Lcn2 Atp6v1h Steap3 Slc46a1 Hmox1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 96%69017 CDK-mediated phosphorylation and removal of Cdc6 Psma4 Psma3 Psma6 Psma5 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdc27 Ube2d1 Psmb5 Cdc16 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Ccne1 Psmb2 Ccne2 Fzr1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Cdk2 Ccna1 Psmd7 Ccna2 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cdc6 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-HSA-1606341.4 IRF3 mediated activation of type 1 IFN Tbk1 Zbp1 Irf3 Nlrp4e Dtx4 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers Slc9a4 Slc9a5 Slc9a2 Slc9a3 Slc9a8 Slc9a9 Slc9a6 Slc9a7 Slc9a1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 96%1234158 Regulation of gene expression by Hypoxia-inducible Factor Epo Vegfa Car9 Cited2 Crebbp Hif1a Epas1 Ep300 Arnt BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency Bckdhb Bckdk Bckdha Dbt Dld COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-HSA-8948216.4 Collagen chain trimerization Col4a1 Col24a1 Col5a1 Col25a1 Col4a2 Col9a2 Col9a3 Col6a6 Col8a1 Col6a3 Col4a5 Col9a1 Col8a2 Col4a6 Col20a1 Col15a1 Col16a1 Col17a1 Col18a1 Col11a1 Col12a1 Col11a2 Col13a1 Col14a1 Col19a1 Col10a1 Col2a1 Col26a1 Col3a1 Col1a2 Col27a1 Col28a1 Col1a1 Col22a1 Col6a1 Col5a2 Col4a3 Col23a1 Col7a1 Col6a2 Col5a3 Col4a4 LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism Prkaca Apoe Nceh1 Angptl8 Angptl4 Angptl3 Clta Apobr Ap2m1 Cltc Ldlrap1 Amn Soat2 Nr1h3 Soat1 Mttp Lsr Prkacb Abcg1 Lcat Fgf21 Mylip Ap2a2 Npc2 Ap2a1 Npc1 Apoa2 Ldlr Hdlbp Apoa4 Apoa5 Creb3l3 Lmf1 Lmf2 Lpl Gpihbp1 Ap2b1 Ubc Ces3b Ap2s1 Apoc1 Apoc2 Lipa Furin Lipg Abca1 Pcsk5 Lipc Pcsk6 Alb Vldlr Pcsk9 Apoc3 Apoc4 Apof P4hb A2m Cubn Nr1h2 Zdhhc8 Sar1b Mbtps1 Mbtps2 Apoa1 Apob MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953080 MPS VII - Sly syndrome (CS DS degradation) Gusb NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration Idh1 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 96%71387 Carbohydrate metabolism Prkacb Gapdhs Chst11 Chst12 Glce Chsy1 Nhlrc1 Uxs1 Chsy3 Chst13 Eno3 Chst14 Eno2 Nup93 Chst15 Nup50 Eno4 Nup35 Phka1 Nup54 Phka2 Pom121 Nup205 Ndst1 Ndst2 Nup188 Galt Tpr Ndst3 Rae1 Ndst4 Ndc1 Omd Nup42 Hspg2 Nup62 Slc35d2 Nup88 Sdc4 Sdc3 Aaas Sdc2 Nup214 Hs3st3b1 Gns Nup210 Abo Nup155 B4galt4 Nup153 B4galt5 Ppp1r3c B4galt6 B4galt7 Pck2 Slc26a11 Pgm2l1 B4gat1 B4galt1 B4galt2 B4galt3 Ext2 Ext1 Sdc1 Akr1a1 Xylb B3gnt7 Gbe1 B3gnt4 Man2c1 B3gnt2 Khk Gys1 Manba Gys2 Pgam2 Pgam1 Akr1b1 Tpi1 Gaa Man2b2 Man2b1 Chst1 Chst3 Prkaca Chst2 Chst5 Dera Chst7 Hyal5 Hyal2 Tkt B3galt2 Pcx B3galt1 Aldob Aldoc Aldoa Rhd Glyctk Hexa Has1 Hexb Gpc1 Idua Stab2 Ncan Bgn EG433182 Gpc3 Cspg5 Gpc2 Cspg4 Has2 Dcn Bcan Gpc5 Has3 Vcan Gpc4 Glb1 Hyal4 Fmod Hyal3 Gpc6 Ids Cd44 Hyal1 Slc17a5 Pygb Glb1l3 Agl Glb1l2 Arsb Pygl Pygm Gusb Hs6st3 Hs6st2 Hs6st1 Epm2a Lyve1 Akr1e2 Papss2 Papss1 Gnpda1 Aldh1a1 Extl2 Naglu Gnpda2 Kera Extl3 Shpk Csgalnact1 Slc37a4 Chpf Agrn St6galnac6 Gyg1 Csgalnact2 Slc37a1 Chp1 Pgd Nup37 B3galt6 B3galt5 Nup160 B3galt4 Gckr Ppp2cb Slc26a2 Ppp2ca Slc26a1 Phkb Nup43 Fut2 Fut1 G6pc1 Cemip Fam20b Ranbp2 Fut4 Galk1 Fut7 Fut9 Hpse Pgk2 Hs2st1 Cryl1 Pxylp1 Hk2 Hk1 Hk3 Nup107 G6pc2 G6pc3 Ust Ogn Slc35b3 Slc35b2 Sord Pfkfb4 Pfkfb3 Pfkfb1 Dse Ppp2r1b Pgm2 Ppp2r1a Slc2a1 Pgm1 Rbks G6pdx Phkg1 Phkg2 Hkdc1 Hmmr Hs3st3a1 Lalba Prps1l1 Prps1 Prps2 Tkfc Nup85 Dsel Fbp1 Fbp2 Hs3st4 Hs3st1 Hs3st2 Hs3st5 Rpe Taldo1 Hs3st6 Bpgm Ppp2r5d Rpia Pfkl Gale B4galnt2 Hpse2 Sec13 B3gat3 B3gat1 B3gat2 Pck1 Galm Prelp Ugp2 Pfkm Pfkp St3gal6 Galns Lum Sgsh Adpgk Xylt1 Xylt2 Dcxr Pgls Nup133 Gck Ubc St3gal4 St3gal2 St3gal1 B3gnt3 Abcc5 Gpi Pgk1 Slc9a1 INACTIVATION OF CDC42 AND RAC1%REACTOME DATABASE ID RELEASE 96%428543 Inactivation of CDC42 and RAC1 Srgap3 Arhgap39 Slit2 Rac1 Robo1 Srgap1 Srgap2 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling Ntrk2 Ntf3 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Tlr4 Tbk1 Traf3 Ticam2 Ticam1 Cd14 Ikbke Tank Ly96 Optn Ubc ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 96%71384 Ethanol oxidation Acss1 Adh5 Adh4 Aldh1b1 Aldh1a1 Acss2 Adh1 Aldh2 Adh7 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 96%9706377 FLT3 signaling by CBL mutants Flt3l Flt3 Cbl Ubc DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9657050 Defective OGG1 Localization TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Smad1 Ppara Smad4 Pparg Hdac2 Hdac1 Rxra Gatad2a Gatad2b Rbbp4 Rbbp7 Mbd3 Chd3 Chd4 Ucp1 Hnrnpu Elovl3 Mta1 Cidea Mta3 Ncoa1 Prdm16 Ebf2 Ppargc1b Bmp7 Zfp423 Mta2 Cox7a1 Ppargc1a SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins Ube2i Nfkb2 Eif2ak2 Ikbkg Rela Sumo3 Ikbke Nfkbia Pias3 Pias4 Topors PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage Hprt1 Dguok Gmpr Adk Dck Aprt Adal Gmpr2 Pnp Ampd3 Ampd2 Ampd1 Ada DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 96%5679096 Defective ABCG5 causes sitosterolemia Abcg8 Abcg5 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 96%9683701 Translation of Structural Proteins Ganab Parp6 Gsk3a Parp8 Gsk3b Canx Parp10 Parp9 Mgat1 Mogs St6galnac3 St6galnac4 St6galnac2 St3gal4 Ubc Ube2i St3gal2 St3gal1 Prkcsh St6gal1 Parp14 Parp16 Galnt1 Parp4 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway Nfatc1 Itpr3 Itpr2 Itpr1 Ppp3r1 Ppp3ca Ppp3cb Map3k7 Ctnnb1 Tcf7 Wnt5a Wnt11 Plcb3 Plcb2 Plcb1 Pde6g Lef1 Gng10 Prkca Gnao1 Nlk Gnat2 Prkg2 Pde6a Pde6b Prkg1 Gng3 Tnrc6c Gng2 Gng4 Tnrc6a Gng7 Tnrc6b Gng8 Tcf7l1 Tcf7l2 Mov10 Ago4 Ago3 Gngt1 Ago2 Gngt2 Ago1 Fzd3 Fzd2 Fzd5 Fzd4 Fzd6 Camk2a Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Apoe Cited4 Cited1 Cited2 Esr1 Tfap2c Kctd15 Tfap2d Mybl2 Tfap2a Kdm5b Tfap2b Ube2i Myc Tgfa Tfap2e Hspd1 Kit Ep300 Dek Yy1 Vegfa Npm1 Wwox Egfr Erbb2 Kctd1 Nop2 Cdkn1a Yeats4 Atad2 Pitx2 Crebbp Cga DEFECTIVE MAOA CAUSES BRUNS%REACTOME DATABASE ID RELEASE 96%5579012 Defective MAOA causes BRUNS Maoa ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9700645 ALK mutants bind TKIs Fn1 Hip1 Alk Eml4 Bcl11a Npm1 Cltc Ppm1b Prkar1a Eif2ak3 Strn Birc6 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70688 Proline catabolism Aldh4a1 Prodh Prodh2 DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 96%73928 Depyrimidination H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Tinf2 H2bc3 H2bc21 H2bc26 H2ab2 H3c8 Neil2 Neil3 Nthl1 H2bu2 Ogg1 H2ac12 Neil1 H2ac11 Mbd4 Smug1 Acd H2ac15 H2ax Terf2ip Terf2 Hist1h2bp Terf1 Hist2h2aa1 H2aj Pot1 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME%R-HSA-168273.5 Influenza Viral RNA Transcription and Replication Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Grsf1 Rps25 Rps26 Rps21 Rpl39l Nup133 Rps15a Dnajc3 Parp1 Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Nup37 Gtf2f2 Nup160 Gtf2f1 Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Rps27 Aaas Nup214 Nup210 Nup155 Nup153 Nup85 Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Hsp90aa1 Ipo5 Sec13 Rpl32 Rps9 Rps7 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) Chmp2a Chmp3 Chmp7 Chmp6 Stam2 Stam Vps36 Ubap1 Tsg101 Chmp4c Mvb12a Chmp4b Mvb12b Vps37a Hgs Vps37b Vps37c Vta1 Vps37d Ubc Snf8 Vps25 Chmp5 Vps28 Vps4a Vps4b RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 96%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Rnf2 Actl6a Actl6b Smarce1 Smarcb1 Pbrm1 Yaf2 Pcgf5 Smarca2 Smarca4 Ep300 Ring1 Smarcd1 Cbx8 Phc2 Smarcd2 Cbx6 Hipk2 Phc1 Cbx4 Cbx2 Smarcc2 Smarcc1 Rybp Arid1a Phc3 Arid1b Csnk2a2 Smarcd3 Cbfb Arid2 Bmi1 Auts2 Csnk2b MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.3 Mitochondrial translation elongation Mrpl14 Mrps30 Mrpl16 Mrps31 Mrpl17 Mrps33 Mrpl18 Mrpl19 Aurkaip1 Mrps34 Mrps35 Tufm Gadd45gip1 Mrpl20 Mrpl3 Mrpl43 Mrpl4 Mrpl44 Mrpl1 Mrpl46 Mrpl2 Mrpl47 Mrpl48 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrpl9 Mrps25 Mrps26 Mrps27 Mrps28 Mrps18c Mrps18b Mrps18a Mrpl50 Mrpl51 Mrpl52 Mrpl53 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrps9 Mrpl36 Mrpl37 Mrpl38 Mrpl39 Mrps10 Mrps11 Mrps12 Mrps14 Chchd1 Mrps15 Mrps16 Mrps17 Ptcd3 Mrps2 Mrps6 Mrps7 Mrpl40 Mrpl41 Mrps5 Mrpl21 Mrpl22 Mrpl24 Mrpl28 Eral1 Mrpl30 Mrpl10 Mrpl54 Dap3 Mrpl11 Mrpl55 Tsfm Mrpl12 Gfm1 Mrpl13 Mrpl57 Mrpl58 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.5 G1 S DNA Damage Checkpoints Psma4 Plk3 Atm Psma3 Psma6 Psma5 Psma2 Psma1 Cdkn2a Psmd12 Psmd11 Phf20 Psmd14 Pcbp4 Psmd13 Chek2 Zfp385a Skp1 Cop1 Psmb5 Psmb4 Psmb7 Psmb6 Cdc25a Psmb1 Psmb3 Ccne1 Psmb2 Ccne2 Fbxw11 Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Mdm2 Ubc Cdk2 Mdm4 Ccna1 Psmd7 Ccna2 Psmd6 Cdkn1a Psmd8 Cdkn1b Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Mapk14 Trp53 Gsk3b Csnk1e Csnk1a1 Nek11 Mapk11 Chek1 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Fkbp1a Tgfb1 Pard6a Pard3 Cgn F11r Rhoa Ubc Prkcz Arhgef18 Tgfbr1 Tgfbr2 Smurf1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function Opn1sw VIRAL MESSENGER RNA SYNTHESIS%REACTOME%R-HSA-168325.6 Viral Messenger RNA Synthesis Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Nup85 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Nup37 Sec13 Gtf2f2 Nup160 Gtf2f1 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 96%5621575 CD209 (DC-SIGN) signaling Prkaca Pak1 Rela Nras Pak3 Pak2 Raf1 Hras Fyn Cd209a Relb Rps6ka5 Icam2 Nfkb1 Crebbp Prkacb Ep300 Lyn ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E Inpp5e Arl13b Pde6d RHOG GTPASE CYCLE%REACTOME%R-HSA-9013408.2 RHOG GTPase cycle Vapb Elmo2 Stx5 Arhgap32 Ykt6 Pak4 Vav2 Prex1 Arhgap35 Pak2 Trio Mcf2 Esyt1 Plekhg3 Mpp7 Ktn1 Ankle2 Cyfip1 Map3k11 Tmpo Arhgap39 Dsg2 Tfrc Lamtor1 Dock3 Lman1 Mcf2l Rab7 Rhog Arhgdib Arhgdia Garre1 Arhgef16 Shmt2 Arhgdig Arfgap3 Erbin Emd Lemd3 Iqgap2 Lbr Diaph3 Cdc42ep1 Depdc1b Vrk2 Vamp3 Epha2 Dock5 Arhgef26 Itsn1 Arhgap5 Itgb1 Dock4 Cav1 Arhgap1 Kalrn Pgrmc2 Vav1 Arhgap21 Letm1 Vangl1 Mcam Ophn1 Pik3r1 Stbd1 Ndufa5 Pld1 Vav3 Dock1 Dock2 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism Ppp1cc Prkaca Gk Plin3 Pnpla5 Plin1 Abhd5 Mgll Ppp1ca Fabp1 Ppp1cb Fabp2 Fabp3 Fabp4 Prkacb Fabp5 Fabp6 Fabp7 Mogat1 Lpin3 Gpat2 Lpin2 Lpin1 Mogat2 Gk2 Fabp12 Dgat2 Dgat1 Lipe Gpd2 Fabp9 Cav1 Gpam ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors Tfap2b Tfap2e Yeats4 Wwox Cited4 Cited1 Cited2 Crebbp Tfap2c Tfap2d Ep300 Tfap2a SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 96%446205 Synthesis of GDP-mannose Gmppb Pmm1 Hk1 Gmppa Pmm2 Mpi TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Ppp2ca Itga5 Itgb3 Ikbkb Vcl Capn2 Ikbkg Stat1 Ikbke Abl1 Nfkb1 Capns1 Capns2 Ppp2r1b Ppp2r1a Rela Gna11 Itgav Itgb1 Ptpn1 Ppp2r2a Ptk2 Anxa2 Gnaq Nfkbia Yap1 Chuk DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5688399.4 Defective ABCA3 causes SMDP3 Abca3 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Cdc37 Nras Gab1 Plcg1 Cbl Sos1 Hras Egfr Ubc Pik3ca Egf Shc1 Hsp90aa1 Pik3r1 SIGNALING BY ROBO RECEPTORS%REACTOME DATABASE ID RELEASE 96%376176 Signaling by ROBO receptors Pak4 Ppp3cb Col4a5 Psma4 Robo1 Srgap1 Psma3 Srgap2 Psma6 Srgap3 Psma5 Psma2 Arhgap39 Psma1 Slit2 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Prkacb Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Nell2 Psmd2 Msi1 Psmd1 Cxcr4 Dag1 Adrm1 Isl1 Sem1 Upf3a Pfn1 Gspt2 Gspt1 Pfn2 Vasp Cxcl12 Abl2 Lhx2 Lhx3 Cul2 Lhx9 Lhx4 Prkca Nrp1 Pabpc1 Flrt3 Slit1 Slit3 Nck2 Ldb1 Akap5 Nck1 Cap1 Dcc Upf2 Usp33 Zswim8 Evl Etf1 Sos2 Robo2 Hoxa2 Ntn1 Pak6 Myo9b Pak5 Cap2 Prkar2a Rps14 Rpl4 Rps16 Rps18 Rps19 Rac1 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 Rps5 Prkaca Rpl24 Rpl26 Rpl22 Pak1 Rpl23 Pak3 Rps25 Pak2 Rps26 Rps21 Rpl39l Rps15a Gpc1 Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Src Rps3 Rps4x Clasp1 Clasp2 Eif4g1 Rnps1 Sos1 Rhoa Magoh Abl1 Rps27 Rbm8a Upf3b Eif4a3 Casc3 Magohb Ncbp2 Ncbp1 Eloc SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis Gfpt1 Gfpt2 Neu1 Dhrsx St6galnac1 St3gal6 Nus1 Slc35c1 St3gal5 Nanp Fpgt Gfus St8sia2 Nans St8sia3 St8sia1 Glb1 Slc17a5 Gmppa Pmm2 Mpi Gmppb Pmm1 St6galnac6 St6galnac3 St6galnac4 St6galnac2 St3gal4 St3gal2 Hk1 St3gal1 St6gal1 Amdhd2 Gnpnat1 Srd5a3 Pgm3 St6galnac5 Cmas Dhdds Nudt14 Alg5 Slc35a1 Dolpp1 Fuom Dpm1 Dpm2 Dpm3 Mvd Gmds St6gal2 Renbp Ctsa Gne St8sia6 St8sia4 St8sia5 Uap1 Dolk Npl Neu2 Neu3 Neu4 Nagk Fcsk ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry Vcp Nrp1 Sdc1 Havcr1 Ace2 Gpc1 Tmprss2 Gpc3 Gpc2 Furin Agrn Hspg2 Gpc5 Sdc4 Sdc3 Gpc4 Sdc2 Gpc6 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling Xpo1 Ccnd1 Egfr Egf Tgfa Bcl2 Elk1 Akt3 Mapk1 Ereg Akt2 Areg Ptk2 Hbegf Akt1 Fos Mapk3 Btc Cdkn1b Epgn Uhmk1 Foxo3 Srf NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-HSA-209560.3 NF-kB is activated and signals survival Ngf Rela Ngfr Sqstm1 Irak1 Nfkb1 Nfkbia Traf6 Ikbkb Ubc CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209905 Catecholamine biosynthesis Ddc Pnmt Th Dbh CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022870 CS-GAG biosynthesis Chst3 Chst11 Chst12 Chsy1 Chst7 Chsy3 Chst13 Chst15 Ncan Csgalnact1 Bgn Cspg5 Chpf Cspg4 Ust Dcn Bcan Vcan Csgalnact2 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%432720 Lysosome Vesicle Biogenesis Arrb1 App Chmp2a Clta Cltc Gns Vamp2 Ap1m2 Arf1 Ap1m1 Dnajc6 Clvs1 Ap1s3 Clvs2 Ap1s2 Dnase2a Ap1b1 Cltb Ap1s1 Ctsz Ap1g1 Vamp7 Bloc1s1 Vamp8 Ap4s1 M6pr Txndc5 Hgs Ap1g2 Ap4m1 Dnm2 Hspa8 Sh3gl2 Ap4e1 METHYLATION%REACTOME DATABASE ID RELEASE 96%156581 Methylation Tpmt Cyp1a2 As3mt Ahcy Nnmt Mtrr Trmt112 Mat2a Mtr Hemk2 Comt Gsto1 Mat2b Mat1a INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176034.4 Interactions of Tat with host cellular proteins Cdk9 Ccnt1 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 96%3656248 Defective HEXB causes GM2-gangliosidosis 2 Hexb ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME%R-HSA-392023.4 Adrenaline signalling through Alpha-2 adrenergic receptor Adra2a Adra2c Adra2b IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112399 IRS-mediated signalling Fgf16 Frs2 Fgf15 Them4 Irs1 Fgf18 Irs2 Fgf2 Pik3c3 Fgf1 Nras Fgf4 Gab1 Fgf10 Fgf3 Fgf6 Sos1 Fgf7 Fgf9 Hras Trib3 Fgf20 Ptpn11 Gab2 Fgf23 Fgfr4 Fgf22 Akt2 Pde3b Tlr9 Pik3r4 Flt3l Pik3cb Pik3ca Flt3 Pdpk1 Pik3r1 Pik3r2 Klb DEFECTIVE ABCC2 CAUSES DJS%REACTOME%R-HSA-5679001.5 Defective ABCC2 causes DJS Abcc2 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions Col18a1 Lama5 Itgav Itgb1 Lamb2 Lama1 Lamc3 Lamb3 Hspg2 Itga7 Lama2 Itga6 Lama3 Nid2 Lama4 Nid1 Lamc1 Itgb4 Lamb1 Itga3 Lamc2 Itga1 Itga2 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-HSA-9616222.3 Transcriptional regulation of granulopoiesis Gata2 Lef1 H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 H2bc3 Rxra Myc Rara H2bc21 Stat3 H2bc26 H2ab2 Ep300 Dek Gfi1 Cebpe H2bu2 Cebpa H2ac12 Csf3r H2ac11 Fli1 Spi1 Klf5 Il6ra Tfdp2 Tal1 Tfdp1 H2ac15 H3c7 H2ax Cbfb Cdk4 Cdk2 E2f1 Myb Hist1h2bp Cdkn1a Hist2h2aa1 H2aj Cebpb ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation Rnf111 Prkn Fbxw10 Fbxw4 Fbxw5 Ube2l3 Fbxw7 Mylip Fbxw9 Itch Fbxw2 Rbx1 Ube2d3 Fbxo4 Stub1 Fbxo6 Nedd4l Fbxo32 Fbxl3 Fbxl5 Cul2 Trim63 Ube2b Kbtbd7 Cul3 Fzr1 Skp2 Cdc20 Lrr1 Nedd4 Rnf220 Fbxl20 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb Sh3rf1 Trim11 Ube2l6 Mex3c Rnf126 Dcaf1 Rnf123 Ubac1 Lnpep Atg7 Rnf114 Rnf115 Hace1 Siah2 Keap1 Kbtbd13 Dzip3 Mkrn1 Ube2g2 Ube2g1 Rnf138 Rnf130 Kbtbd8 Gan Fbxw8 Anapc13 Det1 Klhl9 Psma4 Rbck1 Arih2 Psma3 Rlim Psma6 Klhl2 Psma5 Ube4a Psma2 Spsb2 Psma1 Trim9 Spsb1 Trip12 Spsb4 Psmd12 Lrsam1 Psmd11 Huwe1 Psmd14 Ube2j2 Psmd13 Smurf2 Ube2j1 Skp1 Smurf1 Socs1 Kctd7 Psmb5 Ube2w Psmb4 Ube2m Psmb7 Ube2k Psmb6 Rnf182 Psmb1 Ube2o Psmb3 Ltn1 Psmb2 Ube2h Mgrn1 Fbxw11 Ube2f Ube2a Fbxo10 Btrc Fbxo11 Psma7 Fbxo17 Psmc6 Lmo7 Psmc5 Rnf41 Psmc2 Ube3d Psmc1 Ube3c Psmc4 Lrrc41 Psmc3 Kctd6 Klhl13 Ube2z Ubc Klhl11 Psmd7 Ube3b Psmd6 Ube3a Traip Fbxo21 Psmd8 Ubox5 Psmd3 Fbxo22 Psmd2 Ubr1 Psmd1 Rnf19a Ubr2 Glmn Adrm1 Ubr4 Sem1 Fbxo27 Cul1 Ube2n Ube2v2 Uba5 Uba6 Uba7 Cdc34 Trim69 Ube2v1 Trim71 Klhl25 Ube2e3 Ube2e2 Btbd6 Rnf19b Klhl21 Klhl22 Klhl20 Fbxl8 Fbxo30 Fbxo31 Fbxl4 Fbxl7 Lonrf1 Zbtb16 Uba1 Uba3 Tpp2 Cul5 Cul7 Fbxo41 Traf7 Hectd1 Fbxo44 Hectd2 Hectd3 Thop1 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Klhl42 Ufl1 Fbxo40 Npepps Ube2q2 Ube2q1 Btbd1 Pja2 Pja1 Arel1 Rnf144b Fbxo2 Asb12 Asb11 Siah1a Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc2 Herc3 Ube2r2 Herc1 Rnf6 Rnf7 Rnf4 Fbxo7 Herc6 Fbxo9 Trim21 Vhl Fbxl12 Fbxl13 Fbxl14 Fbxl15 Fbxl16 Trim39 Fbxl18 Fbxl19 Trim37 Mib2 Trim36 Trim32 Anapc5 Trim41 Anapc4 Asb9 Anapc1 Asb8 Anapc2 Asb7 Anapc11 Asb6 Ube2c Asb5 Anapc10 Rnf25 Anapc7 Asb4 Asb3 Cdc27 Asb2 Ube2d1 Rchy1 Cdc16 Asb1 Lnx1 Ube2e1 Cdc23 Wwp1 Socs3 Rnf34 Eloc ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis Trp53 Fbxl3 Fbxl5 Cct6a Ap3m1 Nop56 Gba1 Stat3 Cct3 Cct2 Skic2 Kif13a Fkbp9 Fbxw10 Fbxw4 Fbxw5 Fbxw7 Fbxw9 Ccne1 Xrn2 Ccne2 Sphk1 Tcp1 Hdac3 Cct6b Fbxw2 Fbxo4 Gapdhs Fbxo6 Lonp2 Arfgef2 Cct8 Cct7 Cct5 Cct4 Dcaf7 Wrap53 DEGRADATION OF CRY AND PER PROTEINS%REACTOME%R-HSA-9932298.1 Degradation of CRY and PER proteins Fbxl3 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Ube2d1 Psmb5 Psmb4 Cry1 Psmb7 Cry2 Psmb6 Psmb1 Per1 Psmb3 Per3 Psmb2 Fbxw11 Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622327 Postsynaptic nicotinic acetylcholine receptors Chrnd Chrne Chrng Chrna3 Chrnb4 Chrna2 Chrnb3 Chrnb2 Chrna1 Chrna6 Chrna5 Chrna4 Chrna9 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 96%8874081 MET activates PTK2 signaling Src Hgf Met Lama5 Itgb1 Lamb2 Ptk2 Lama1 Lamc3 Lamb3 Lama2 Lama3 Lama4 Lamc1 Lamb1 Itga3 Lamc2 Itga2 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction Crb3 Patj Pals1 Gja1 Tjp1 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190241 FGFR2 ligand binding and activation Fgf16 Fgf18 Fgf2 Fgf1 Fgf4 Fgf10 Fgf3 Fgf6 Fgf7 Fgf9 Fgf20 Fgf23 Fgf22 Fgfbp3 Fgfbp1 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency Gss SIGNALING BY TCF7L2 MUTANTS%REACTOME%R-HSA-5339700.5 Signaling by TCF7L2 mutants Ctbp1 Ctbp2 Tcf7l2 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013423 RAC3 GTPase cycle Pak1 Arhgap32 Ykt6 Pak4 Vav2 Prex1 Arhgap35 Pak2 Trio Mcf2 Esyt1 Mpp7 Srgap2 Cyfip1 Tmpo Arhgap39 Slc1a5 Dsg2 Ncf1 Ncf2 Ncf4 Brk1 Ocrl Swap70 Amigo2 Noxa1 Rac3 Git1 Tfrc Baiap2 Arhgap15 Abl2 Arhgap17 Nckap1l Tiam1 Fermt2 Bcr Arhgap6 Lamtor1 Arap3 Arap2 Rapgef1 Baiap2l1 Arhgap26 Syde1 Abr Nckap1 Slitrk5 Slitrk3 Nhs Git2 Wasf2 Wasf1 Noxo1 Dock10 Racgap1 Lman1 Taok3 Snap23 Rab7 Cyba Jag1 Abi2 Arhgdib Abi1 Cybb Garre1 Nox3 Arhgap42 Nox1 Erbin Emd Lemd3 Lbr Diaph3 Cdc42ep1 Depdc1b Vrk2 Vamp3 Epha2 Arhgap5 Itgb1 Cav1 Arhgap1 Pgrmc2 Arhgap21 Vangl1 Mcam Ophn1 Pik3r1 Stbd1 Pik3r2 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 96%8949275 RUNX3 Regulates Immune Response and Cell Migration Runx3 Itga4 Itgal Spp1 Cbfb DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death Mlkl H2bc9 Cast H2bc7 Prdx2 H2bc8 App Jun H2bc3 Golga2 Prdx1 Capn1 Cdkn2a Capn2 Tradd Sod2 Traf2 Cdk5r1 Bcl2l11 Ywhae Cdk5 H2ab2 Fasl Capns1 Capns2 Cdc25c Foxo3 Lmnb1 Cdc25b Fadd Cdc25a H2bu2 Ripk3 Casp8 Ripk1 Gsdme Hist2h2aa1 Eed Trp53 H2bc14 H2ac20 H2bc21 H2bc26 Rbbp4 Rbbp7 H2ac12 Prim2 H2ac11 Prim1 C1qbp Pola2 Pola1 Dnmt3a H2ac15 Dnmt3b H3c7 Dnmt1 Ezh2 H2ax Suz12 Hist1h2bp H2aj IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants Pdgfra DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963743 Digestion and absorption Pnliprp2 Pnliprp1 Pnlip Gucy2c Lipf Pir Amy2a5 Amy1 Alpi Guca2b Sis Slc2a2 Guca2a Slc5a1 Lct Slc2a5 Chia Chit1 Mgam Treh Cel Clps RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance Gtf2h3 Taf4 Taf3 Gtf2h5 Taf2 Ercc2 Taf1 Ccnh Ercc3 Cdk7 Taf15 Taf11 Taf13 Taf12 Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Polr2c Taf9 Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Taf8 Gtf2h2 Gtf2h1 Taf7 Gtf2f2 Taf6 Gtf2h4 Gtf2f1 Taf5 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling Erbb2 Egf Plcg1 Egfr NEURODEGENERATIVE DISEASES%REACTOME%R-HSA-8863678.3 Neurodegenerative Diseases Cast Prdx2 App Jun Golga2 Prdx1 Capn1 Capn2 Sod2 Cdk5r1 Bcl2l11 Ywhae Cdk5 Fasl Capns1 Capns2 Cdc25c Foxo3 Lmnb1 Cdc25b Cdc25a DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 96%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) Slc34a2 DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME DATABASE ID RELEASE 96%5619081 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) Slc6a3 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer Hey2 Hey1 Mib2 Ncor2 Skp1 Mamld1 Notch1 Rbx1 Ubc Kat2b Kat2a Cul1 Hdac2 Hdac1 Hdac5 Hdac4 Myc Hdac7 Hdac6 Hdac9 Hdac8 Ncor1 Dll4 Hes1 Jag2 Jag1 Adam10 Ep300 Cdk8 Neurl1b Tbl1x Adam17 Neurl1a Dll1 Mib1 Hdac3 Tbl1xr1 Psen1 Psen2 Ncstn Maml1 Aph1b Maml2 Heyl Hdac11 Hdac10 Hes5 Rbpj Ccnc Crebbp DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) Slc22a18 PLUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164525.3 Plus-strand DNA synthesis Ppia THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis Lck Pak2 Cd4 Fyn Atp6v1h Ap2m1 Ap1m2 Arf1 Ap1m1 Pacs1 Ap1s3 Ap1s2 Ap2a2 Ap1b1 Ap1s1 Ap2a1 Ap1g1 B2m H2-Q10 Ap2b1 Cd28 Ap2s1 Rac1 Elmo1 Hck Cd8b1 Dock2 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%191273 Cholesterol biosynthesis Acat2 Cyp51a1 Fdft1 Dhcr7 Srebf1 Srebf2 Ggps1 Sc5d Lbr Lss Tm7sf2 Pmvk Mvd Fdps Idi1 Mvk Plpp6 Hsd17b7 Nsdhl Dhcr24 Sqle Ebp Arv1 Msmo1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) Ltc4s BIOFILM FORMATION%REACTOME DATABASE ID RELEASE 96%9931953 Biofilm formation Upk1a Epcam TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 Taf4 Cnot6l Taf3 Taf2 Taf1 Apaf1 Rffl Cradd Pidd1 Prdx2 Tpx2 Jun Tmem219 Prdx1 Banp Fanci Cdk5r1 Trp63 Fancc Ywhae Cdk5 Sgk1 Cdc25c Tnfrsf10b Casp1 Bax Fas Jmy Ndrg1 Trp53 Rbl2 Dyrk2 Trp53inp1 Rbl1 Aurka Prdm1 Mdc1 Sfn L3mbtl1 Ddb2 Cdkn2a Aifm2 Ehmt2 Ehmt1 Txn Bid Mbd3 Tigar Hipk1 Hipk2 Ccne1 Ccne2 Cox6a1 Cox6a2 Tfdp2 Rabggta Tfdp1 Rabggtb Ppp1r13l Kmt5a Mdm2 Cdk2 Ppp1r13b Mdm4 E2f1 Ccna1 Ccna2 Cdkn1a Daxx Cdkn1b Rgcc Cpap Cnot3 Cnot2 Cnot1 Cnot7 Cnot6 Map2k6 Cnot4 Ppp2cb Ppp2ca Cnot9 Cnot8 Mapkapk5 Cox6b1 Cox6b2 Pin1 Trp53bp2 Rrm2b Hdac2 Triap1 Ppp2r1b Ppp2r1a Prelid3a G6pdx Pten Birc5 Prmt5 Nlrc4 E2f4 E2f7 E2f8 Aurkb Ppp2r5c Pip4p1 Cox8a Nuak1 Cox7b Prmt1 Bcl2l14 Phf20 Pcbp4 Chek2 Bnip3l Zfp385a Msh2 Pms2 Mlh1 Cox5a Npm1 Ttc5 Ubc Polr2c Polr2d Polr2a Polr2b Pou4f1 Polr2g Pou4f2 Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Perp Gtf2h4 Gtf2f1 Trp73 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Ywhah Hdac1 Prkaa1 Prkaa2 mt-Co1 Akt3 Txnrd1 Akt2 Akt1 Meaf6 Cox4i1 Kat5 Cox4i2 Exo1 Nbn Rfc5 Prelid1 Ywhaz Mov10 Rfc3 Chd3 Pcna Chd4 Rfc4 Ago4 Ago3 Rfc2 Ago2 Ago1 Gadd45a Hus1 Atrip Brip1 Dna2 Plk2 Igfbp3 Csnk2a2 Rad51d Blm Gls Chek1 Mta2 Rad9a Casp6 Bard1 Casp2 Fos Rad9b Ddit4 Top3a Wrn Mre11a Rad50 Rpa1 Topbp1 Rpa2 Pip4k2b Rad17 Rbbp8 Pip4k2a Higd1c Brca1 Rpa3 Plk3 Rad1 Atm Cdk13 Cdk12 mt-Co2 mt-Co3 Gatad2a Gatad2b Gpi Rictor Btg2 Cdk1 Chm Ing5 Ing2 Prkag3 Brd7 Prkag1 Prkag2 Fancd2 Prr5 Ywhab Ywhag Rptor Pdpk1 Smyd2 Trp53rkb Mapk14 Csnk2b Usp2 Usp7 Slc38a9 Lamtor5 Lamtor4 Rraga Mlst8 Rragb Sesn2 Coxfa4 Lamtor1 Cnot11 Rragc Sesn3 Lamtor2 Rragd Tsc2 Mtor Tsc1 Mapk11 Stk11 Steap3 Tnrc6c Cnot10 Rbbp4 Rbbp7 Atf2 Brpf3 Tnrc6a Brpf1 Tnrc6b Carm1 Mapkap1 Kat6a Prkab2 Ep300 Prkab1 Ell Bcl6 Nelfa Nelfb Nelfe Taf15 Ctdp1 Taf11 Tnks1bp1 Taf13 Taf12 Ccnk Tbp Taf4b Gpx2 Taf9 Gls2 Supt4h1a Tcea1 Nelfcd Cox7a1 Supt16 Cox7a2 Cdk9 Rnf34 Ccnt2 Ssrp1 Ccnt1 Crebbp Pml Taf8 Eloa Taf7 Taf6 Eloc Cox7a2l Taf5 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 96%110381 Resolution of AP sites via the single-nucleotide replacement pathway Polb Apex1 Xrcc1 Lig3 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity Pip4p1 Taf4 Taf3 Taf2 Taf1 Nuak1 Rffl Tpx2 Banp Cdk5r1 Trp63 Phf20 Cdk5 Chek2 Zfp385a Sgk1 Ttc5 Ubc Pou4f1 Pou4f2 Jmy Trp73 Trp53 Hdac1 Prkaa1 Prkaa2 Akt3 Akt2 Akt1 Meaf6 Dyrk2 Trp53inp1 Kat5 Exo1 Aurka Nbn Rfc5 Rfc3 Chd3 Chd4 Rfc4 Prdm1 Rfc2 Hus1 Atrip Brip1 Dna2 Csnk2a2 Blm Chek1 Mta2 Rad9a Bard1 Rad9b Top3a Wrn L3mbtl1 Mre11a Rad50 Rpa1 Topbp1 Rpa2 Pip4k2b Rad17 Rbbp8 Pip4k2a Brca1 Rpa3 Plk3 Rad1 Atm Cdkn2a Gatad2a Gatad2b Ehmt2 Rictor Ehmt1 Cdk1 Mbd3 Ing5 Ing2 Hipk1 Hipk2 Prkag3 Ppp1r13l Prkag1 Brd7 Kmt5a Prkag2 Mdm2 Cdk2 Ppp1r13b Mdm4 Ccna1 Ccna2 Daxx Prr5 Pdpk1 Smyd2 Trp53rkb Mapk14 Csnk2b Map2k6 Ppp2cb Usp2 Ppp2ca Usp7 Mapkapk5 Mlst8 Pin1 Trp53bp2 Mtor Hdac2 Mapk11 Stk11 Rbbp4 Rbbp7 Brpf3 Brpf1 Mapkap1 Kat6a Prkab2 Ep300 Prkab1 Ppp2r1b Ppp2r1a Taf15 Taf11 Taf13 Taf12 Prmt5 Tbp Taf4b Taf9 Aurkb Supt16 Rnf34 Ppp2r5c Ssrp1 Pml Taf8 Taf7 Taf6 Taf5 LEISHMANIA INFECTION%REACTOME%R-HSA-9658195.3 Leishmania infection Elmo2 Adora2b Entpd1 Nt5e Entpd5 C3ar1 Ggt1 Prkx Jun Il18 Plcg2 Cyfip1 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Btk Dpep1 Dpep2 Nfkb1 Dvl1 Dvl2 Dvl3 Prkacb Actb Myo5a Ggt5 Arpc3 Arpc2 Nlrp3 Pstpip1 Cyfip2 Rela Arpc5 Arpc4 Ctsg Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Casp1 Adcy5 Adcy6 Gnaz Wnt5a Fcgr1 Gsdmd Adcy9 Fcgr3 Il1a Fcgr4 Il1b Ptk2 Syk Mefv Fgr Myh2 Gnai2 Gnai1 Gnai3 Myo1c Nckipsd Prkar1b Was Wasf3 Pycard Gnat3 Prkar2b Cysltr2 Cysltr1 Wasl Sugt1 P2rx7 Gng10 P2rx4 Myo10 Nck1 Gng3 Gng2 Prkar1a Gng4 Gng7 Gng8 Myo9b Lyn Yes1 Prkar2a Gngt1 Gngt2 Rhbdf2 Il10 Cd163 Plk2 Fzd7 Myh9 Ahcyl1 Nfkb2 Rac1 Gnb2 Gnb1 Vav1 Gnb4 Txnip Gnb3 Gnb5 Gng11 Gng12 Gng13 Vav3 Prkaca Cd3g Itpr3 Itpr2 Vav2 Itpr1 Mapk8 Txn Actg1 Il6 Hsp90ab1 Mapk1 Mapk3 Furin Brk1 Mapk14 Noxa1 Baiap2 Nckap1l Plcg1 Crk Nckap1 Fyn Wasf2 Wasf1 Noxo1 Abl1 Cyba Abi2 Abi1 Hmox1 Adam17 Nox1 C3 Elmo1 Hck Dock1 INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity Mkrn1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Xiap Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Stub1 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Csnk2b Rnf146 Tnks2 Tnks Trim27 Otud3 Wwp2 Usp13 Frk Akt3 Akt2 Akt1 Pten Nedd4 Csnk2a2 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells Kcnmb1 Kcnma1 Kcnn2 Chrna10 Chrna9 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Pcna Rpa2 Pold4 Pold3 Rpa3 Lig1 Exo1 Msh6 Msh2 Pold2 Pms2 Pold1 Mlh1 Rpa1 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism Neu1 St6galnac1 St3gal6 St3gal5 Nanp St6galnac3 St8sia2 St6galnac4 Nans St6galnac2 St8sia3 St3gal4 St8sia1 St3gal2 St3gal1 St6gal1 Glb1 Slc17a5 St6galnac5 Cmas Slc35a1 St6gal2 Ctsa Gne St8sia6 St8sia4 St6galnac6 St8sia5 Npl Neu2 Neu3 Neu4 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling Cd274 Prdm1 Sin3a Stat3 Hdac3 Il2rg Dnmt1 Hif1a Ep300 Hdac2 Hdac1 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855204 Synthesis of IP3 and IP4 in the cytosol Plch2 Plch1 Pld4 Plce1 Pten Plcd1 Plcb3 Plcd4 Plcb2 Plcd3 Plcb1 Itpk1 Inppl1 Plcg1 Plcg2 Inpp5d Plcb4 Itpka Synj1 Inpp5b Ocrl Itpkc Itpkb Plcz1 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 96%9673163 Oleoyl-phe metabolism Pm20d1 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 96%9648025 EML4 and NUDC in mitotic spindle formation Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Cenpo Cenpn Cenpm Mis12 Plk1 Nup133 Cenpl Zwilch Cenpk Cenpi Cenph Cenpf Cenpe Clasp1 Clasp2 Pafah1b1 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Kif2b Kif2c Dync1li2 Pmf1 Ska1 Dync1li1 Ahctf1 Nup107 Eml4 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Ppp2r1b Ppp2r1a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Xpo1 Nuf2 Nek9 Nek6 Nup85 Nek7 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%427975 Proton oligopeptide cotransporters Slc15a1 Slc15a3 Slc15a4 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B Naglu FERTILIZATION%REACTOME%R-HSA-1187000.4 Fertilization Zp2 Kcnu1 Hyal5 B4galt1 Adam2 Catsperd Catsperb Catsperg1 Izumo4 Acr Ovgp1 Catsper4 Izumo2 Catsper2 Izumo1 Adam30 Hvcn1 Catsper3 Catsper1 Adam21 Cd9 Zp1 Zp3 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission Dlg1 Dlg3 Grik5 Dlg4 Grik2 Grik1 Grik4 Grik3 Ncald Prkx Prkacb Ap2a1 Prkcb Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Gnai2 Gnai1 Gnai3 Prkar1b Gnat3 Prkar2b Plcb3 Plcb2 Plcb1 Gng10 Prkca Prkaa1 Akap5 Prkaa2 Gng3 Gng2 Prkar1a Gng4 Rps6ka1 Gng7 Grin2a Gng8 Camk4 Camk1 Dlg2 Actn2 Prkar2a Ppm1f Nefl Ppm1e Grin1 Gngt1 Grin2d Gngt2 Grin2c Camk2g Camk2d Camk2b Rac1 Camk2a Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 Prkaca Cacng8 Cacng4 Cacng2 Cacng3 Camkk1 Camkk2 Grip2 Nsf Gria4 Gria3 Kcnj3 Prkcg Kcnj2 Gria1 Cask Arhgef9 Gnal Gabrg2 Gabrg3 Lin7a Myo6 Lin7b Lin7c Grin3b Rasgrf1 Rasgrf2 Pick1 Gabra4 Gabra3 Gabra6 Gabra5 Gabbr1 Gabra2 Gabbr2 Chrnd Gabra1 Src Chrne Kif17 Chrng Chrna3 Glra3 Chrnb4 Glra2 Chrna2 Glra1 Chrnb3 Nrg1 Chrnb2 Prkag3 Rps6ka6 Chrna1 Tspan7 Chrna6 Kcnj9 Chrna5 Kcnj6 Prkag1 Chrna4 Kcnj5 Prkag2 Mdm2 Chrna9 Kcnj4 Glrb Grip1 Gabrr1 Gabrr3 Mapk1 Gabrr2 Apba1 Mapk3 Nrgn Gabrq Kcnj10 Gabrb1 Rps6ka3 Gabrb3 Pdpk1 Gabrb2 Rps6ka2 Kcnj12 Htr3b Htr3a Kcnj15 Kcnj16 Git1 Gria2 Nras Hras Grin2b Prkab2 Prkab1 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development Neurog3 Onecut3 Nkx2-2 Nkx6-1 Onecut1 Insm1 Mafa Ptf1a Pdx1 Fgf10 Pax6 Neurod1 Hnf4g Foxa2 Foxa3 Rfx6 Hnf1a Foxo1 Hnf1b Akt3 Akt2 Akt1 Hes1 Ep300 Mamld1 Notch1 Slc2a2 Gck Kat2b Maml1 Maml2 Iapp Kat2a Rbpj Crebbp Ins2 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 96%209543 p75NTR recruits signalling complexes Prkci Ripk2 Ngf Myd88 Ngfr Sqstm1 Irak1 Traf6 Ikbkb Ubc ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade Slc24a1 Sag Gngt1 Rho Gnb1 Gnat1 Cnga1 Pde6g Pde6a Pde6b MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%975871 MyD88 cascade initiated on plasma membrane Mapk9 Mapk7 Mapk8 App Ikbkb Jun Peli1 Elk1 Ikbkg Map3k7 Traf2 Map3k8 Nfkb1 Skp1 Fbxw11 Rela Btrc Casp8 Ubc Mapk1 Nfkbib Mapk3 Rps6ka3 Irak1 Nfkbia Mapkapk3 Rps6ka2 Traf6 Mapkapk2 Cul1 Ube2n Map2k7 Mapk14 Chuk Map2k6 Ppp2cb Ppp2ca Ube2v1 Trp53 Map2k4 Tab3 Map2k3 Tab2 Tab1 Mapk10 Map2k1 Mapk11 Ripk2 Myd88 Rps6ka5 Nkiras1 Atf2 Nkiras2 Rps6ka1 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Peli2 Ppp2r1a Peli3 Tlr5 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Tifa Dusp6 Alpk1 Irak2 Ager Nlrx1 Nfkb2 Mef2a Usp14 Usp18 Fos Ppp2r5d Mef2c RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression Rorc Srebf1 Hdac3 Rora Ppara Ncoa2 Ncoa1 Tbl1xr1 Smarcd3 Rxra Ncoa6 Med1 Cpt1a Nr1d1 Ncor1 Ppargc1a Helz2 Crebbp Carm1 Nrip1 Ep300 Chd9 Tbl1x SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 96%9669933 Signaling by kinase domain mutants of KIT Kit DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis Eed H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 H2bc3 H2bc21 H2bc26 Rbbp4 Rbbp7 H2ab2 H2bu2 H2ac12 H2ac11 Prim2 Prim1 Pola2 Pola1 Dnmt3a H2ac15 Dnmt3b H3c7 Dnmt1 Ezh2 H2ax Suz12 Gsdme Hist1h2bp Hist2h2aa1 H2aj SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME%R-HSA-6802952.3 Signaling by BRAF and RAF1 fusions Kdm7a Arrb1 Jak2 Zc3hav1 Fgb Clcn6 Fga Agk Rap1b Aggf1 Ksr1 Qki Vwf Fam131b Cnksr2 Cnksr1 Fgg Araf Itgb3 Pebp1 Raf1 Tln1 Vcl Fn1 Bcl2l11 Src Papss1 Mapk1 Braf Mapk3 Ywhab Rap1a Map2k2 Nras Map2k1 Mark3 Hras Csk Itga2b Camk2g Camk2d Camk2b Camk2a Mprip Ap3b1 Kiaa1549 Tent4a Akap9 Snd1 Atg7 Lmna Trak1 Agtrap Trim24 Apbb1ip Fam114a2 Arrb2 Iqgap1 Fxr1 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium Nedd1 Cc2d2a Tmem67 Actr1a Tuba1a Dynlrb2 Dynlrb1 Cep97 Cys1 Dctn2 Dctn3 Ift70b Rpgrip1l Rab11a Dynlt2a1 Cct3 Ift88 Cct2 Ift81 Ywhae Exoc3 Exoc4 Exoc5 Cluap1 Exoc6 Exoc1 Exoc2 Dynlt2b Sstr3 Exoc7 Exoc8 Ift80 Pcnt Traf3ip1 Tcp1 Arl6 Tuba4a Fbf1 Arl3 Cep250 Sdccag8 Cep78 Ift140 Dynlt5 Cep76 Iqcb1 Cep72 Cep70 Bbs2 Bbs1 Tubb5 Plk4 Ift22 Kif3a Kif3b Ift27 Kif3c Ift25 Cct8 Ahi1 Cep89 Cct5 Smo Cep135 Cct4 Nphp4 Nphp3 Cep131 Cep83 Lztfl1 Prkar2b Mks1 Nphp1 Rab11fip3 Ift52 Arf4 Mkks Unc119b Tubb4b Haus7 Tubb4a Haus8 Ttc21b Cdk5rap2 C2cd3 Ift56 Pkd2 Pkd1 Ift57 Mark4 Cep57 Pcm1 Rp2 Asap1 Ssna1 Bbs9 Mchr1 Bbs7 Tubg1 Bbs5 Ift122 Bbs4 Ofd1 Bbs10 Ift43 Bbs12 Septin2 Cep162 Ift46 Cep63 Rab3ip Cep152 Haus3 Kif24 Haus4 Haus5 Haus6 Sfi1 Ttbk2 Csnk1d Haus1 Wdr35 Haus2 Ift74 Tctn3 Tctn1 Tctn2 Cnga4 Kifap3 Hsp90aa1 Cnga2 Dync2h1 Ift70a1 Cep164 B9d1 Prkaca Ccp110 Atat1 Alms1 Gbf1 Cetn2 Tnpo1 Trip11 Rab8a Dync2li1 Dync2i1 Dync2i2 Ift172 Ttc8 Cep43 Wdr19 Cep41 Plk1 Sclt1 Ninl Cdk1 Nek2 Kif17 Cpap Clasp1 Ywhag Pafah1b1 Csnk1e Hdac6 Mapre1 Rho Inpp5e Arl13b Dynll1 Dynll2 Pde6d Ppp2r1a Dync1h1 Dync1i2 Ckap5 Akap9 B9d2 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 96%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter Polr3gl Gtf3a Crcp Polr3a Polr3d Brf1 Polr3e Polr1c Polr3b Polr3c Polr3h Polr3f Polr1d Polr3g Polr3k Gtf3c2 Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 Gtf3c5 Bdp1 Tbp Polr2h Polr2e Polr2f Polr2k RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 96%8941284 RUNX2 regulates chondrocyte maturation Ihh Cbfb Gli2 Hdac4 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 96%6811440 Retrograde transport at the Trans-Golgi-Network Napb Ric1 Scoc Naa35 Vti1a Naa38 Napg Rab6b Vamp4 Nsf Rab6a Rgp1 Naa30 Stx16 Arfip2 Rhobtb3 Rabepk Arfrp1 Plin3 Rab9 Golga4 M6pr Rab43 Tmf1 Golga1 Vamp3 Vps51 Vps52 Vps53 Vps54 Arl1 Gcc2 Gcc1 Rab9b Cog1 Usp6nl Cog2 Stx6 Cog3 Cog4 Cog6 Cog7 Cog8 Igf2r Napa PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins Nudt16 Adprm Nudt5 Nudt15 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73776 RNA Polymerase II Promoter Escape Gtf2h3 Taf4 Taf3 Gtf2h5 Taf2 Ercc2 Taf1 Ccnh Ercc3 Cdk7 Taf15 Taf11 Taf13 Taf12 Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Polr2c Taf9 Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Taf8 Gtf2h2 Gtf2h1 Taf7 Gtf2f2 Taf6 Gtf2h4 Gtf2f1 Taf5 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6782315 tRNA modification in the nucleus and cytosol Osgep Trmt5 Wdr4 Urm1 Ctu1 Ctu2 Trmt44 Mettl1 Tyw1 Trmt1 Thada Cdkal1 Ftsj1 Trit1 Trmt9b Pus3 Qtrt2 Qtrt1 Trmt61a Trdmt1 Tyw2 Lcmt2 Tyw3 Eprs1 Tyw5 Pus7 Dus2 Trmt10a Trmt11 Nsun2 Trmt13 Tprkb Nsun6 Trmt112 Adat1 Alkbh8 Adat2 Thg1l Trp53rkb GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 96%430116 GP1b-IX-V activation signalling Vwf Gp9 Gp1bb Flna Pik3r1 Gp5 Gp1ba Raf1 Ywhaz MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 96%430039 mRNA decay by 5' to 3' exoribonuclease Lsm5 Dcp1a Dcp1b Lsm1 Edc3 Edc4 Xrn1 Lsm6 Lsm7 Patl1 Ddx6 Dcp2 Lsm2 Lsm3 Lsm4 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane Atat1 Gbf1 Rab8a Ttc8 Cys1 Rab11a Cct3 Cct2 Exoc3 Exoc4 Exoc5 Exoc6 Exoc1 Exoc2 Sstr3 Exoc7 Exoc8 Tcp1 Arl6 Arl3 Bbs2 Bbs1 Cct8 Cct5 Smo Cct4 Nphp3 Lztfl1 Rab11fip3 Arf4 Mkks Unc119b Pkd2 Pkd1 Hdac6 Rho Rp2 Inpp5e Arl13b Asap1 Pde6d Bbs9 Mchr1 Bbs7 Bbs5 Bbs4 Bbs10 Bbs12 Rab3ip Cnga4 Cnga2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 96%174113 SCF-beta-TrCP mediated degradation of Emi1 Fbxo5 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fzr1 Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Cdc20 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME DATABASE ID RELEASE 96%9702518 STAT5 activation downstream of FLT3 ITD mutants Grb2 Bcl2l1 Cdkn1a Flt3 Stat5a Stat5b Pim1 Nox4 Ptpn11 Gab2 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Cyp2u1 Cyp1b1 Cyp2c50 Cyp1a2 Cyp4a32 Cyp4f15 Cyp2c65 Cyp1a1 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression Sp1 Prmt1 Jun Tgfa Ebag9 Cxxc5 Smc1a Tle3 Kdm1a Greb1 Ddx5 Ctsd Kdm4b Kank1 Pou2f1 Fkbp4 Chd1 Tff3 Zfp217 Foxa1 Ncoa3 Usf1 Usf2 Nr5a2 Kctd6 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 Cxcl12 Esr1 H2ac20 Hdac1 Myc Pgr Kat5 Jund Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 H2ax Myb Hist1h2bp Fos H2aj Hsp90aa1 Axin1 Gata3 Fosb Cited1 H2bc9 H2bc7 H2bc8 H2bc3 H2ab2 Yy1 Hsp90ab1 H2bu2 Cbfb Ccnd1 Kat2b Hist2h2aa1 Smc3 H2bc14 Rad21 Bcl2 H2bc21 Tnrc6c H2bc26 Atf2 Tnrc6a Tnrc6b Carm1 Nrip1 Stag2 Stag1 Ep300 Tbp Ncoa2 Ncoa1 Gtf2a1 Gtf2a2 Med1 Cdk9 Ccnt1 Crebbp Gpam L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373760 L1CAM interactions Pak1 Dlg1 Vav2 Dlg3 Dlg4 Itgb3 Ncan Clta Ap2m1 Lama1 Cltc Sdcbp Lamc1 Lamb1 Ap2a2 Ap2a1 Spta1 Nrp2 Rps6ka6 Scn9a Scn5a Sptb L1cam Dnm2 Scn1a Sh3gl2 Hspa8 Scn1b Egfr Ap2b1 Lypla2 Kcnq3 Ap2s1 Itgav Kcnq2 Mapk1 Numb Shtn1 Mapk3 Gap43 Ank3 Chl1 Ank1 Scn10a Rps6ka3 Scn2a Scn2b Rps6ka2 Dnm1 Kif4 Sptan1 Csnk2b Dnm3 Rps6ka4 Dcx Ranbp9 Ezr Scn7a Map2k2 Scn11a Scn3a Scn3b Ephb2 Nrp1 Itga9 Map2k1 Itga10 Itga5 Dpysl2 Alcam Nfasc Scn8a Rdx Ncam1 Msn Itga2b Nrcam Scn4a Rps6ka5 Sptbn1 Scn4b Sptbn2 Cntn2 Cntn1 Rps6ka1 Cntnap1 Cntn6 Sptbn4 Itga1 Itga2 Csnk2a2 Rac1 Itgb1 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 96%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Ncbp2 Ncbp1 Zfp473 Snrpb Slbp Lsm10 Lsm11 Snrpd3 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation H2bc9 H2bc7 H2bc8 Jun H2bc3 H2ab2 H2bu2 Mamld1 Elane Tfdp2 Tfdp1 Notch1 Ccnd1 Kat2b E2f1 E2f3 Kat2a Hist2h2aa1 Trp53 H2bc14 H2ac20 Prkci H2bc21 Tnrc6c H2bc26 Tnrc6a Tnrc6b Notch4 Ep300 Elf3 Mov10 Sirt6 Notch2 H2ac12 H2ac11 Notch3 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 H2ax Maml1 Maml2 Hist1h2bp Rbpj H2aj Crebbp DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-HSA-5654687.4 Downstream signaling of activated FGFR1 Frs2 Flrt1 Flrt2 Fgf2 Fgf1 Nras Gab1 Fgf4 Plcg1 Fgf10 Frs3 Fgf3 Flrt3 Fgf6 Sos1 Fgf9 Hras Fgf20 Ptpn11 Pik3ca Fgf23 Fgf22 Pik3r1 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702506 Drug resistance of FLT3 mutants Flt3 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA Hadha Hadhb Acadl REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation Pip4p1 Trp53 Pip4k2b Pip4k2a Pin1 Hdac2 Hdac1 Akt3 Akt2 Gatad2a Meaf6 Akt1 Gatad2b Rbbp4 Rbbp7 Brpf3 Brpf1 Mbd3 Kat6a Ep300 Ing5 Ing2 Chd3 Chd4 Brd7 Mta2 Pml Map2k6 SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM Fgf2 Fgfr2 Fgf1 Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112315 Transmission across Chemical Synapses Dlg1 Dlg3 Grik5 Dlg4 Grik2 Grik1 Grik4 Grik3 Ncald Prkx Prkacb Slc5a7 Ap2a1 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Gnai2 Gnai1 Gnai3 Prkar1b Gnat3 Prkar2b Gng10 Akap5 Gng3 Gng2 Gng4 Gng7 Gng8 Prkar2a Gngt1 Gngt2 Aldh5a1 Slc18a2 Slc18a3 Slc6a11 Slc6a13 Abat Camk2g Unc13b Slc22a2 Camk2d Slc22a1 Glul Camk2b Slc6a1 Slc6a4 Camk2a Ache Syn3 Gnb2 Syn2 Syn1 Gnb1 Cacna2d1 Gnb4 Cacna2d3 Gnb3 Cacna2d2 Gnb5 Gng11 Ppfia2 Ppfia4 Gng12 Ppfia1 Gng13 Cacnb3 Cacnb4 Slc32a1 Cacnb1 Prkaca Cacnb2 Cacng8 Bche Cacng4 Cacna1e Cacng2 Cacna1a Cacng3 Cacna1b Naaa Camkk1 Camkk2 Chat Grip2 Rab3a Nsf Dnajc5 Gria4 Cplx1 Gria3 Tomt Kcnj3 Arl6ip5 Prkcg Gad1 Gad2 Kcnj2 Gria1 Cask Arhgef9 Gnal Gabrg2 Gabrg3 Lin7a Lin7b Lin7c Grin3b Rasgrf1 Rasgrf2 Pick1 Gabra4 Gabra3 Gabra6 Gabra5 Gabbr1 Gabra2 Gabbr2 Gabra1 Kif17 Glra3 Glra2 Glra1 Nrg1 Rps6ka6 Tspan7 Kcnj9 Kcnj6 Kcnj5 Hspa8 Mdm2 Kcnj4 Glrb Grip1 Gabrr1 Gabrr3 Gabrr2 Apba1 Nrgn Gabrq Kcnj10 Gabrb1 Comt Gabrb3 Rps6ka3 Gabrb2 Rps6ka2 Kcnj12 Htr3b Htr3a Kcnj15 Kcnj16 Grin2b Aldh2 Slc1a1 Slc1a3 Prkcb Slc1a2 Slc38a2 Slc1a7 Slc1a6 Slc38a1 Slc6a12 Plcb3 Plcb2 Plcb1 Prkca Prkaa1 Prkaa2 Maoa Prkar1a Rps6ka1 Grin2a Camk4 Camk1 Dlg2 Actn2 Ppm1f Nefl Ppm1e Grin1 Grin2d Grin2c Gls Rac1 Myo6 Chrnd Chrne Src Chrng Chrna3 Chrnb4 Chrna2 Chrnb3 Chrnb2 Prkag3 Chrna1 Chrna6 Chrna5 Prkag1 Chrna4 Prkag2 Chrna9 Mapk1 Mapk3 Pdpk1 Git1 Gria2 Nras Hras Snap25 Syt1 Vamp2 Prkab2 Stx1a Prkab1 Slc6a3 Gls2 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) Rpa2 Actl6a Cetn2 Xrcc1 Lig3 Rpa3 Rnf111 Polk Nfrkb Usp45 Parp2 Pole Ino80e Tfpt Ino80d Ino80c Parp1 Ino80b Actr5 Actr8 Ruvbl1 Xpa Xpc Rad23a Rad23b Cops4 Cops3 Actb Cops6 Cops2 Yy1 Ercc1 Ercc4 Ercc5 Cops8 Chd1l Ino80 Cops7a Cops7b Rbx1 Ubc Cops5 Mnat1 Gtf2h2 Gtf2h1 Ube2n Ube2v2 Gtf2h4 Gtf2h3 Gtf2h5 Ercc2 Ccnh Sumo3 Ercc3 Cdk7 Pias3 Ube2i Ddb1 Pias1 Lig1 Cul4a Cul4b Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Rfc1 Rfc2 Pold4 Pold3 Pole3 Pole2 Pole4 Ddb2 Rpa1 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 96%73929 Base-Excision Repair, AP Site Formation H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Tinf2 H2bc3 H2bc21 H2bc26 H2ab2 H3c8 Neil2 Neil3 Nthl1 H2bu2 Ogg1 H2ac12 Neil1 H2ac11 Mbd4 Smug1 Acd Mpg H2ac15 H2ax Terf2ip Terf2 Hist1h2bp Terf1 Hist2h2aa1 H2aj Pot1 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism Oxct2a Hmgcl Bdh2 Bdh1 Oxct1 Hmgcll1 Hmgcs2 Acat1 Aacs MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%5662702 Melanin biosynthesis Slc45a2 Oca2 Dct Tyrp1 Tyr DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 H2ac20 Lig1 Kpna1 Rfc5 Pold2 Pold1 Rfc3 Pcna H2ac12 Rfc4 H2ac11 Orc5 Rfc1 Orc4 Rfc2 Orc6 Pold4 Orc1 Pold3 H2ac15 Mcm8 Orc3 H3c7 Orc2 Dna2 H2ax Pole3 Pole2 Pole4 Hist1h2bp Top3a H2aj Kpnb1 Rpa1 Rpa2 H2bc9 Rpa3 H2bc7 H2bc8 Cdc7 H2bc3 Pole Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 H2ab2 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 H2bu2 Anapc15 Ccne1 Ccne2 Fzr1 Skp2 Gins2 Gins1 Mcm7 Gins4 Gins3 Cdk2 Mcm3 Mcm4 Ccna1 Mcm5 Ccna2 Mcm6 Cdc45 Mcm2 Polg2 Hist2h2aa1 Cdt1 Gmnn Kpna6 Fen1 Twnk Dbf4 Polrmt Rnaseh1 Mcm10 Exog Ssbp1 Mgme1 Polg H2bc14 Cdc6 H2bc21 H2bc26 Prim2 Prim1 Pola2 Pola1 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants Kit ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Rps5 Eif3m Eif3i Eif3l Eif3k Eif3f Eif3e Rps25 Eif3h Rps26 Pabpc1 Eif3g Eif3b Eif3a Rps21 Eif3d Eif3c Eif4h Eif3j2 Eif4b Rps15a Eif4e Eif1ax Eif4a2 Eif2s3x Eif4a1 Eif2s2 Eif2s1 Rps27l Rps27 Rps3 Rps4x Rps14 Rps16 Rps18 Rps19 Rpsa Rps10 Rps11 Eif4ebp1 Eif4g1 Rps9 Rps7 GSD 0%REACTOME%R-HSA-3858516.4 GSD 0 Gys2 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654693 FRS-mediated FGFR1 signaling Frs2 Fgf2 Fgf1 Nras Fgf4 Fgf10 Frs3 Fgf3 Fgf6 Sos1 Fgf9 Hras Fgf20 Ptpn11 Fgf23 Fgf22 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) Ubc Sem1 Ube2n Ube2v2 Pias4 Ube2i Kat5 Lig1 Exo1 Eme1 Mus81 Nbn Gen1 Rfc5 Pold2 Pold1 Rfc3 Pcna Sirt6 Rfc4 Fignl1 Mdc1 Rfc1 Rfc2 Pold4 Pold3 Hus1 Atrip Brip1 Dna2 H2ax Pole3 Rad51c Rad51d Pole2 Blm Rad51b Chek1 Pole4 Rad9a Hist1h2bp Bard1 Rad9b Top3a Slx4 Wrn Mre11a Herc2 Spidr Palb2 Rad51 Rad50 Firrm Rpa1 Rnf4 Topbp1 Rpa2 Rad17 Rbbp8 Rtel1 Brca2 Brca1 Xrcc3 Rad51ap1 Xrcc2 H2bc9 Rpa3 H2bc7 Polk H2bc8 Rad1 Atm H2bc3 Polh Pole H3c8 Ercc1 Ercc4 H2bu2 Cdk2 Ccna1 Ccna2 H2bc14 H2bc21 Ppp4r2 H2bc26 Timeless Tipin Abl1 Ppp4c Clspn Trp53bp1 Abraxas1 Brcc3 Rnf168 Nsd2 Rad52 Babam1 Babam2 Uimc1 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 96%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 Rorc Rorb Rora Ppara Rxra Ncor1 Atf2 Helz2 Carm1 Nrip1 Ep300 Tbl1x Mef2d Clock Bmal1 Crtc3 Hdac3 Crtc2 Rai1 Ncoa2 Ncoa1 Tbl1xr1 Smarcd3 Crtc1 Ncoa6 Npas2 Med1 Nr1d1 Ppargc1a Crebbp Mef2c Chd9 Sirt1 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events Prkaca Prkar2b Plcb3 Itpr3 Plcb2 Camkk1 Itpr2 Plcb1 Camkk2 Itpr1 Prkca Prkcg Prkx Prkar1a Plcb4 Prkacb Camk4 Prkar2a Pla2g4a Grk2 Pde1b Pde1c Prkcd Adcy3 Pde1a Gna11 Adcy4 Gna15 Adcy1 Gna14 Adcy2 Adcy7 Camk2g Adcy8 Adcy5 Camk2d Adcy6 Ahcyl1 Camk2b Adcy9 Camk2a Mapk1 Gnaq Prkar1b RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines Jak2 Actl6a Actl6b Smarce1 Prmt6 Prmt1 H2ac20 Smarcb1 Pbrm1 Rbbp7 H2ab2 Smarca2 Carm1 Smarca4 Smarcd1 H2ac12 Smarcd2 H2ac11 Prmt5 Dnmt3a Smarcc2 H2ac15 H2ac21 Smarcc1 H3c7 Coprs H2ax H2ac25 Arid1a Hist1h2af Arid1b Prmt7 Smarcd3 Ccnd1 Prmt3 H2ac1 Cdk4 Arid2 Wdr77 Hist2h2aa1 H2aj Wdr5 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 96%9665244 Resistance of ERBB2 KD mutants to sapitinib Erbb2 Cdc37 Erbin Hsp90aa1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.4 Signaling by TGF-beta Receptor Complex in Cancer Fkbp1a Smad2 Smad3 Tgfb1 Smad4 Tgfbr1 Tgfbr2 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 96%1679131 Trafficking and processing of endosomal TLR Ctss Unc93b1 Lgmn Hsp90b1 Tlr9 Tlr8 Tlr7 Ctsk Tlr3 Ctsl Ctsb INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166663 Initial triggering of complement Colec11 Mbl2 C1qc C3 Fcn2 C4a Crp Cfd Cfb C1qb C2 C1qa C1rb Gzmm Colec10 C1s2 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-HSA-74751.5 Insulin receptor signalling cascade Fgf16 Frs2 Fgf15 Them4 Irs1 Fgf18 Insr Irs2 Grb10 Fgf2 Pik3c3 Fgf1 Nras Fgf4 Gab1 Fgf10 Fgf3 Fgf6 Sos1 Fgf7 Fgf9 Hras Trib3 Fgf20 Ptpn11 Gab2 Fgf23 Fgfr4 Fgf22 Akt2 Pde3b Tlr9 Pik3r4 Flt3l Pik3cb Pik3ca Shc1 Mapk1 Mapk3 Flt3 Pdpk1 Ins2 Pik3r1 Pik3r2 Klb RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 96%9665249 Resistance of ERBB2 KD mutants to afatinib Erbb2 Cdc37 Erbin Hsp90aa1 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-HSA-1834949.6 Cytosolic sensors of pathogen-associated DNA Trim21 Stat6 Cgas Sting1 Trim56 Aim2 Ddx41 Irf7 Dhx9 Ikbkb Prkdc Trex1 Dhx36 Trim32 Xrcc6 Xrcc5 Polr3gl Nlrc3 Ikbkg Crcp Ticam1 Polr3a Polr3d Polr3e Nfkb1 Polr1c Polr3b Polr3c Polr3h Polr3f Polr1d Polr3g Polr3k Rela Ctnnb1 Ripk3 Ripk1 Ubc Nfkbib Polr2h Polr2e Polr2f Polr2k Nfkbia Chuk Tbk1 Myd88 Zbp1 Irf3 Nlrp4e Dtx4 Nkiras1 Nkiras2 Ep300 Nfkb2 Tlr3 Mre11a Crebbp REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME%R-HSA-9909615.2 Regulation of PD-L1(CD274) Post-translational modification Sel1l Magt1 Psma4 Cul3 Psma3 Psma6 Mib2 Psma5 Psma2 Psma1 Tmem258 Psmd12 Psmd11 Psmd14 Psmd13 Rnf185 Skp1 Derl3 Psmb5 Nek2 Psmb4 Derl2 Psmb7 Derl1 Psmb6 Psmb1 Psmb3 Psmb2 Stt3a Stt3b Spop Vcp Btrc Rbx1 Psma7 Ostc Psmc6 Prkag3 Psmc5 Psmc2 Psmc1 Ccnd1 Psmc4 Prkag1 Psmc3 Prkag2 Cdk4 Ubc Cops5 Psmd7 Psmd6 Tusc3 Psmd8 Erlec1 Psmd3 Psmd2 Dad1 Psmd1 Ywhag Adrm1 Sem1 Cul1 Ddost Csnk2b Cd274 Gsk3b Pdcd1 Rnf5 Prkaa1 Prkaa2 Erlin2 Erlin1 Rpn2 Rpn1 Pdcd1lg2 Prkab2 Prkab1 B3gnt3 Csnk2a2 Jak1 Os9 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 96%204005 COPII-mediated vesicle transport Stx5 Ykt6 Nsf Gria1 Golga2 Tgfa Ctsc Scfd1 Ppp6r1 Ppp6r3 Lman2 Sec22c Sec22b Sec22a Tfg Preb Trappc6b Ppp6c Trappc9 Trappc6a Trappc5 Trappc4 Sec31b Ctsz Trappc3 Sec31a Trappc2 Trappc1 F5 F8 Rab1a Stx17 Rab1b Trappc2l Gosr2 Lman1l Tbc1d20 Cd59b Uso1 Sec23ip Trappc10 Sec16b Sec16a Mcfd2 Lman2l Serpina1d Cnih1 Gorasp1 Cnih3 Cnih2 Folr1 Napa Ankrd28 Napb Bet1 Napg Areg Lman1 Sar1b Sec23a Csnk1d Sec24d Sec24c Col7a1 Sec24b Sec13 Sec24a MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702600 midostaurin-resistant FLT3 mutants Flt3 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9940951 Interaction of NuRD complexes with transcription factors Phf6 Zfp592 Tcf19 Cdk2ap1 G6pc1 Cdk2ap2 Nr2f2 Mbd2 Zmynd8 H2bc14 Ikzf3 H2bc9 Znf687 H2bc7 Ikzf2 H2ac20 H2bc8 Ikzf1 Chd5 Hdac2 Hdac1 H2bc3 Zfp827 H2bc21 Gatad2a H2bc26 Gatad2b Rbbp4 Rbbp7 H2ab2 Mbd3 Chd3 H2bu2 Chd4 H2ac12 H2ac11 Mta1 H2ac15 Mta3 H3c7 H2ax Fbp1 Nr2c2 Mta2 Hist1h2bp Hist2h2aa1 H2aj Pck1 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 96%5579030 Defective CYP19A1 causes AEXS Cyp19a1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis Trpc3 Rasgrp2 Itpr3 Itpr2 Rasgrp1 Itpr1 Daglb Dgka Dgkb Abhd6 Dgke Abhd12 Mgll Dgkg Dgkh Dgki Dgkk Dgkq Prkch Dgkz Dagla Prkce Prkcd Trpc6 Trpc7 Prkcq LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 Prkaca Camk4 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening Gtf2h3 Taf4 Taf3 Gtf2h5 Taf2 Ercc2 Taf1 Ccnh Ercc3 Cdk7 Taf15 Taf11 Taf13 Taf12 Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Polr2c Taf9 Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Taf8 Gtf2h2 Gtf2h1 Taf7 Gtf2f2 Taf6 Gtf2h4 Gtf2f1 Taf5 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5658623 FGFRL1 modulation of FGFR1 signaling Fgf23 Fgf22 Fgf18 Spred1 Fgf2 Spred2 Fgf4 Fgf10 Fgf3 Fgfrl1 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 96%444821 Relaxin receptors Rxfp3 Rln3 Rxfp2 Rxfp1 Rln1 Insl3 Rxfp4 Insl5 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%9675136 Diseases of DNA Double-Strand Break Repair Topbp1 Rpa2 Rad17 Rbbp8 Brca2 Brca1 Rad51ap1 Xrcc2 Rpa3 Rad1 Atm Kat5 Exo1 Nbn Rfc5 Rfc3 Rfc4 Rfc2 Hus1 Atrip Brip1 Dna2 Rad51c Rad51d Blm Rad51b Rad9a Bard1 Rad9b Top3a Wrn Mre11a Palb2 Sem1 Rad51 Rad50 Rpa1 RHOB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013026 RHOB GTPase cycle Actc1 Jup Rhpn2 Arhgap32 Stk10 Net1 Arhgef10l Vav2 Prex1 Stard8 Arhgap35 Dlc1 Stard13 Mcf2 Pkn2 Pkn1 Arhgap39 Flot2 Flot1 Rock2 Rock1 Tjp2 Tfrc Bcr Arhgap26 Abr Racgap1 Mcf2l Snap23 Myo9b Arhgdig Erbin Rhob Diaph3 Anln Arhgef17 Depdc1b Slk Arhgef11 Vamp3 Arhgef10 Cavin1 Iqgap3 Diaph1 Daam1 Arhgap5 Akap13 Cit Cav1 Arhgef25 Arhgap1 Arhgef28 Sowahc Arhgap21 Stom Vangl1 Pkn3 Arhgef3 Mcam Arhgef2 Ophn1 Pik3r1 Arhgef1 Pik3r2 Pcdh7 Ect2 Myo9a Rtkn ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 96%428540 Activation of RAC1 Pak1 Pak4 Pak3 Pak2 Sos1 Robo1 Nck2 Nck1 Slit2 Rac1 Sos2 Pak6 Pak5 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events Net1 Arhgef10l Vav2 Prex1 Trio Mcf2 Tiam2 Rhoc Plxnb1 Arhgef15 Arhgef19 Ngef Adra1b Arhgef9 Adra1a Adra1d Gna12 Arhgef7 Arhgef6 Btk Tbxa2r Arhgef4 Gna13 Fgd2 Rasgrf2 Fgd1 Fgd4 Arhgef37 Fgd3 Arhgef39 Arhgef38 Arhgef40 Plekhg5 Plekhg2 Rock2 Rock1 Tiam1 Gng10 Sos1 Rhoa Abr Arhgef18 Gng3 Gng2 Gng4 Sos2 Gng7 Mcf2l Gng8 Arhgef16 Gngt1 Gngt2 Rhob Arhgef17 Arhgef11 Arhgef10 Arhgef26 Itsn1 Akap13 Gnb2 Kalrn Vav1 Gnb1 Gnb4 Gnb3 Arhgef3 Gnb5 Arhgef2 Gng11 Arhgef1 Gng12 Ect2 Gng13 Vav3 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids Acot8 Hsd17b4 Ehhadh Acaa1a Slc27a2 Abcd1 Decr2 Acot4 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease Nras Golga4 Pdgfra Pik3cb Sos1 Fip1l1 Etv6 Hras Bin2 Kdr Pik3ca Stat3 Wdr48 Stat1 Strn Pik3r1 Pik3r2 Kank1 S PHASE%REACTOME DATABASE ID RELEASE 96%69242 S Phase Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Smc1a Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Cdc25b Psmb7 Cdc25a Psmb6 Psmb1 Psmb3 Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Mnat1 Psmd1 Adrm1 Sem1 Cul1 Ccnh Cdk7 Myc Rbl2 Akt3 Akt2 Akt1 Lig1 Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Orc5 Rfc1 Orc4 Rfc2 Orc6 Pold4 Orc1 Pold3 Mcm8 Orc3 Orc2 Dna2 Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Pole Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Ccne1 Ccne2 Fzr1 Tfdp2 Tfdp1 Skp2 Rb1 Gins2 Gins1 Ccnd1 Mcm7 Gins4 Cdk4 Gins3 Cdk2 Mcm3 Ptk6 Mcm4 E2f1 Ccna1 Cks1b Mcm5 Ccna2 Cables1 Mcm6 Max Lin54 Cdc45 Cdkn1a Esco1 Mcm2 Esco2 Cdkn1b Cdt1 Lin9 Gmnn Wee1 Lin37 Fen1 Smc3 Gsk3b Rad21 Wapl Cdc6 Rbbp4 Stag2 Stag1 Pds5b Pds5a Prim2 Prim1 Pola2 Pola1 E2f4 E2f5 Cdca5 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375280 Amine ligand-binding receptors Htr7 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Htr2a Htr2c Htr2b Drd1 Adrb2 Drd2 Adrb1 Drd3 Drd4 Drd5 Adrb3 Adra1b Taar8b Adra1a Htr1d Adra1d Taar6 Htr1f Taar9 Taar2 Taar5 Htr1b Htr1a Taar1 Htr5a Gpr143 Htr4 Chrm1 Adra2a Hrh1 Adra2c Chrm3 Adra2b Htr6 Chrm2 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%5693532 DNA Double-Strand Break Repair Xrcc1 Lig3 Prkdc Xrcc6 Xrcc5 Chek2 Kdm4b Ubc Sem1 Ube2n Ube2v2 Trp53 Pias4 Ube2i Kat5 Lig1 Exo1 Eme1 Mus81 Nbn Gen1 Rfc5 Pold2 Pold1 Rfc3 Pcna Sirt6 Rfc4 Fignl1 Mdc1 Rfc1 Rfc2 Pold4 Pold3 Hus1 Atrip Brip1 Dna2 H2ax Pole3 Rad51c Rad51d Pole2 Blm Rad51b Chek1 Pole4 Rad9a Hist1h2bp Bard1 Rad9b Top3a Slx4 Wrn Mre11a Herc2 Spidr Palb2 Rad51 Rad50 Firrm Rpa1 Rnf4 Topbp1 Rpa2 Rad17 Rbbp8 Rtel1 Brca2 Brca1 Xrcc3 Rad51ap1 Xrcc2 Mapk8 H2bc9 Rpa3 H2bc7 Polk H2bc8 Rad1 Atm H2bc3 Polh Parp2 Pole Parp1 H3c8 Ercc1 Ercc4 H2bu2 Cdk2 Ccna1 Ccna2 Fen1 H2bc14 H2bc21 Ppp4r2 H2bc26 Timeless Tipin Abl1 Ppp4c Clspn Trp53bp1 Abraxas1 Brcc3 Rif1 Rnf168 Paxip1 Nsd2 Lig4 Rad52 Baz1b Babam1 Nhej1 Babam2 Tdp2 Uimc1 Tdp1 Xrcc4 Bap1 Ppp5c Apbb1 Kdm4a Smarca5 Polq Polm Dclre1c Eya2 Eya1 Eya4 Eya3 Ubxn1 Poll REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9759475 Regulation of CDH11 Expression and Function Sp1 Jup Angptl4 Tnrc6c Tnrc6a Tnrc6b Mov10 Ago4 Ago3 Ago2 Ctnnb1 Ago1 Zeb2 Ctnnd1 Hoxc8 Cdh8 Heyl Adam19 Adam33 Cdh24 Ctnna1 Snai1 Prdm8 Ilf3 Foxf1 Bhlhe22 Cdh11 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME%R-HSA-4341670.3 Defective NEU1 causes sialidosis Neu1 Ctsa Glb1 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 Dlgap5 Hey2 Pbx1 Hey1 Plxnd1 Ptcra Ybx1 Mib2 Wwp2 Egf Stat1 Dll4 Hes1 Jag2 Jag1 Ep300 Adam10 Neurl1b Fabp7 Neurl1a Dll1 Mib1 Notch3 Mamld1 Notch1 Ubc Egfr Psen1 Kat2b Psen2 Ncstn Maml1 Aph1b Maml2 Heyl Kat2a Hes5 Rbpj Crebbp Wwc1 Tacc3 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS Fkbp1a Jak2 Impdh1 Sap30l Suds3 Brms1 Rcor1 Jak3 Sap30 Brd4 Tyk2 Sap18b Blnk Cul3 Arid4b Crbn Plcg2 Arid4a Ace2 Cd79a Cd79b Ifnar1 Hmg20b Gatad2a Ap2m1 Ifngr2 Ifngr1 Gatad2b S1pr1 Btk Sigmar1 Kdm1a Fnta Fntb Stat2 Mbd3 Il1r1 Fkbp4 Hsp90ab1 Ap2a2 Ap2a1 Sh3kbp1 Rock2 Mta1 Rock1 Rbx1 Mta3 Ripk1 Ap2b1 Ap2s1 Tubb5 Syk Furin Comt Nr3c1 Cysltr1 Sos1 Pdcd1 Hdac2 Hdac1 Nck1 Tbk1 Zbp1 Itga4 Tlr9 Rbbp4 Rbbp7 Chd3 Chd4 Atp1a2 Fxyd4 Atp1a1 Fxyd1 Il6ra Atp1a3 Fxyd7 Fxyd6 Rest Mta2 Itgb1 Jak1 Tlr7 Vav1 Atp1b1 Nfe2l2 Atp1b3 Atp1b2 Hsp90aa1 Keap1 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs Nudt21 Cpsf7 Cpsf1 Cstf2 Cpsf2 Cstf3 Cpsf3 Pabpn1 Cstf2t Wdr33 Fip1l1 Cpsf4 Ncbp2 Ncbp1 Sympk Cstf1 Papola Clp1 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662361.2 Sensory processing of sound by outer hair cells of the cochlea Cask Twf1 Myo3a Myo3b Fscn2 Xirp2 Grxcr2 Eps8 Grxcr1 Chrna9 Kcnq4 Myo7a Pls1 Pcdh15 Tmc1 Espnl Ush1g Tmc2 Cib2 Lhfpl5 Otog Slc26a5 Myo1c Whrn Twf2 Clic5 Sptan1 Epb41l3 Tmie Strc Cdh23 Ush1c Ezr Otogl Mpp1 Gsn Pjvk Eps8l2 Espn Myo15a Tprn Ripor2 Rdx Msn Kcnmb1 Kcnma1 Kcnn2 Sptbn1 Chrna10 Myh9 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS Sftpc IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME%R-HSA-9709275.2 Impaired BRCA2 translocation to the nucleus Brca2 Sem1 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR Egf Tgfa Ereg Areg Hbegf Btc Epgn Egfr POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764790 Positive Regulation of CDH1 Gene Transcription Sp1 Foxp2 Klf4 Rb1 Zeb2 Arid1a Foxa2 Klf9 Strap Tfap2a Foxj2 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 Fgf23 Fgfr1 Fgf2 Fgf1 Fgf4 Fgf6 Fgf9 Fgf20 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters Slc12a1 Slc12a4 Slc12a5 Slc12a2 Slc12a3 Slc12a6 Slc12a7 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 96%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Prelp Omd Lum Ogn B4galt1 Fmod Kera DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage Hprt1 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA Pabpc1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Hspb1 Psmb5 Hspa1a Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Hspa8 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Eif4g1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors Col4a1 Colec11 Apoe Col4a2 Ftl1 Hsp90b1 Col3a1 Fth1 Col1a2 Col1a1 Calr Marco Msr1 Colec12 Apoa1 Scgb3a2 Scara5 Apob AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol Bad Gsk3a Mkrn1 Gsk3b Akt1s1 Tsc2 Mdm2 Akt3 Akt2 Cdkn1a Akt1 Cdkn1b Chuk Casp9 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME%R-HSA-9699150.3 Defective DNA double strand break response due to BARD1 loss of function Bard1 Brca1 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 96%159424 Conjugation of carboxylic acids Glyatl3 Acsm2 Acsm4 Acsm5 Glyat Acsm1 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013409 RHOJ GTPase cycle Jup Pak1 Arhgap32 Gja1 Pak4 Prex1 Pak3 Arhgap35 Pak2 Trio Mpp7 Tmpo Wipf2 Arhgef7 Slc1a5 Ocrl Was Git1 Tfrc Wasl Lamtor1 Arhgap26 Syde1 Wwp2 Steap3 Git2 Arl13b Snap23 Rab7 Cdc42bpa Cdc42bpb Rhoj Diaph3 Slc4a7 Cdc42ep1 Depdc1b Fnbp1 Dock8 Vamp3 Fnbp1l Cpne8 Scrib Iqgap3 Fmnl3 Nipsnap2 Arhgap5 Cav1 Arhgap1 Arhgap21 Stom Vangl1 Ophn1 Pik3r1 Pik3r2 SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 Spint1 Hpn Mst1 Mst1r Spint2 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME%R-HSA-9833576.1 CDH11 homotypic and heterotypic interactions Jup Cdh8 Cdh24 Ctnnb1 Ctnna1 Ctnnd1 Cdh11 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%1614635 Sulfur amino acid metabolism Bhmt2 Tstd1 Got1 Got2 Ethe1 Fmo1 Apip Enoph1 Adi1 Tst Cth Gadl1 Cdo1 Slc25a10 Ahcy Mtrr Mpst Mtr Sqor Mri1 Suox Ado Txn2 Mat1a Mtap Bhmt Csad Cbs PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Abce1 Rpl39l Pelo Rps15a Rps27l Rplp2 Rps27 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins Rraga H2bc14 H2bc9 H2bc7 H2bc8 Prkdc H2bc3 Cdc73 Rtf1 Rnf181 H2bc21 Shprh Tmem129 Leo1 Ube2b Skic8 Selenos Pex2 Ube2j2 Rad18 Rnf152 Rnf40 Pex14 Ube2d1 Rnf144a Pex13 Ube2e1 Pex12 Derl1 Hltf H2bu2 Pcna Pex10 Ube2l3 Wac Ctr9 Paf1 Ube2a Vcp H2-Q10 Rnf20 Ube2d3 Ubc Bcl10 Hist1h2bp Ube2v2 Ube2n TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 96%168138 Toll Like Receptor 9 (TLR9) Cascade Tlr4 Irf7 App Ikbkb Jun Peli1 Ikbkg Map3k7 Ticam2 Traf2 Ticam1 Cd14 Nfkb1 Skp1 Fbxw11 Rela Btrc Casp8 Ubc Nfkbib Irak1 Nfkbia Cul1 Traf6 Ube2n Chuk Ube2v1 Trp53 Tab3 Tab2 Tab1 Rps6ka1 Tifa Alpk1 Nfkb2 Fos Mapk9 Mapk7 Mapk8 Elk1 Map3k8 Tasl Rbsn Eea1 Irf5 Mapk1 Mapk3 Rps6ka3 Mapkapk3 Rps6ka2 Mapkapk2 Map2k7 Mapk14 Map2k6 Ppp2cb Ppp2ca Map2k4 Slc15a4 Map2k3 Mapk10 Pik3c3 Map2k1 Mapk11 Ripk2 Myd88 Rps6ka5 Tlr9 Pik3r4 Nkiras1 Atf2 Nkiras2 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Ppp2r1a Peli2 Peli3 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Usp18 Tlr7 Ppp2r5d Ly96 Mef2c DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9918485 Dengue Virus Attachment and Entry Uba7 Havcr1 Gpc1 Cd209a Uba1 Uba3 Gpc3 Ap2m1 Gpc2 Cd14 Hspg2 Gpc5 Sdc4 Sdc3 Gpc4 Sdc2 Gpc6 Ap2a2 Ap2a1 Tyro3 Mapre3 Mrc1 Emc4 Timd4 Sdc1 Cldn1 Mertk Ap2b1 Rnasek Cd300a Ap2s1 Axl Hspa5 Pros1 Rpsa Ly6e Furin Agrn Gas6 Atg7 Pik3r1 Uba5 Uba6 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 96%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) Ltc4s Ggt1 Alox5 Lta4h Cyp4a32 Cyp4f15 Alox5ap Alox15 Dpep1 Cyp4f39 Dpep2 Cyp4f17 Abcc1 Cyp4a12b Mapkapk2 Cyp4f3 Cyp4f40 Ggt5 Cyp4b1 Ptgr1 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167243.5 Tat-mediated HIV elongation arrest and recovery Supt5h Ell Nelfa Nelfb Nelfe Ctdp1 Polr2c Polr2d Polr2a Polr2b Supt4h1a Polr2g Tcea1 Polr2h Nelfcd Polr2e Supt16 Polr2f Cdk9 Polr2k Ssrp1 Polr2i Ccnt1 Polr2j Eloa Gtf2f2 Eloc Gtf2f1 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway Mgat3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME%R-HSA-9824585.3 Regulation of MITF-M-dependent genes involved in pigmentation Ss18 Mlph Actl6a Dpf1 Dpf2 Smarce1 Rab27a Dpf3 Mlana Lef1 Ss18l1 Pmel Bcl7a Bcl7b Bcl7c Irf4 Myrip Tfap2a Sytl2 Smarcb1 Akt2 Smarca2 Smarca4 Myo5a Actb Smarcd1 Smarcd2 Usf1 Ctnnb1 Smarcc2 Sox10 Smarcc1 Arid1a Arid1b Smarcd3 Dct Tyrp1 Tyr Gpr143 Mapk14 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 96%983712 Ion channel transport Trpc3 Ano7 Ano6 Trpa1 Trpv1 Ano5 Clcn6 Trpv3 Ano4 Ano2 Mcoln1 Ano1 Mcoln2 Trpv2 Ttyh3 Ttyh2 Trpc4ap Trpm2 Sgk3 Trpm1 Sgk2 Trpm8 Atp2c1 Trpm7 Atp2c2 Trpm4 Scnn1a Trpm3 Scnn1b Trpm6 Unc79 Trpm5 Scnn1g Slc17a3 Ostm1 Tpcn1 Tpcn2 Clcn7 Clca4a Clcn4 Clcn5 Bsnd Sgk1 Ubc Nedd4l Ryr2 Fkbp1b Ryr1 Atp2a1 Atp1a2 Fxyd4 Atp1a1 Atp2a3 Fxyd1 Atp2a2 Atp1a3 Fxyd7 Sri Fxyd6 Trdn Camk2g Ryr3 Camk2d Camk2b Asph Camk2a Atp1b1 Stom Atp1b3 Atp2b2 Atp1b2 Atp2b1 Atp2b4 Atp2b3 Raf1 Atp6v0b Atp6v0a2 Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v0a1 Atp6v1c2 Pdzd11 Atp6v1c1 Wwp1 Atp6ap1 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Asic5 Atp6v1h Asic4 Atp10a Atp10b Atp10d Atp8a1 Asic1 Atp8a2 Clcn2 Clcn3 Slc9c1 Clcn1 Atp4a Atp4b Atp11b Atp11a Atp13a1 Atp11c Atp8b2 Atp8b1 Atp8b3 Atp13a2 Atp13a4 Atp13a5 Atp12a Wnk4 Atp9b Atp9a Nalcn Tsc22d3 Wnk1 Wnk3 Wnk2 Slc9b1 Best1 Slc9b2 Best3 Clcnkb Best2 Trpv5 Clcnka Trpv4 Atp7b Trpv6 Clca1 Clca2 Trpc6 Atp7a Trpc5 Trpc7 Stoml3 Cutc Mcoln3 Trpc1 Ano10 Trpc4 Ano8 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-3232118.9 SUMOylation of transcription factors Trp53 Sumo3 Mta1 Mitf Pias3 Tfap2c Pias4 Mdm2 Tfap2b Ube2i Cdkn2a Pias1 Hic1 Trp53bp1 Sp3 Foxl2 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Nop2 Npm1 Hspd1 Mybl2 Tfap2a DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function Rbbp8 Brca2 Brca1 Rad51ap1 Brip1 Xrcc2 Dna2 Rad51c Rad51d Atm Blm Rad51b Bard1 Top3a Kat5 Exo1 Wrn Mre11a Nbn Sem1 Palb2 Rad51 Rad50 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Rps27l Etf1 Rplp2 Rps27 Rpl22l1 Rplp1 Rpl13a Rpl18a Apeh Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Trmt112 Rpl37 Rpl39 Rps10 Hemk2 Rps11 Rpl7 Rpl32 Rps9 Gspt2 Rps7 Gspt1 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Ell Nelfa Nelfb Nelfe Ctdp1 Ccnk Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Polr2b Supt4h1a Polr2g Tcea1 Polr2h Nelfcd Polr2e Supt16 Polr2f Cdk9 Polr2k Ccnt2 Mnat1 Ssrp1 Polr2i Ccnt1 Polr2j Gtf2h2 Eloa Gtf2h1 Gtf2f2 Gtf2h4 Eloc Gtf2f1 LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5632681 Ligand-receptor interactions Cdon Ptch1 Dhh Ihh Hhip Boc Shh Gas1 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69109 Leading Strand Synthesis Pcna Rfc4 Prim2 Rfc1 Prim1 Rfc2 Pola2 Pold4 Pola1 Pold3 Rfc5 Pold2 Pold1 Rfc3 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 96%1483166 Synthesis of PA Alpi Pla2g2e Pla2g2d Pla2g4a Gpat2 Pla2g2f Pla2g4d Gpd1l Lpcat4 Pld2 Pla2g12a Acp6 Pla2g5 Lclat1 Gpd2 Gnpat Gpat4 Pla2g1b Gpat3 Pla2r1 Liph Miga2 Agpat5 Pla2g10 Miga1 Lpcat1 Gpd1 Ddhd1 Agpat3 Agpat4 Agpat1 Agpat2 Pld1 Gpam ASSEMBLY OF THE HIV VIRION%REACTOME%R-HSA-175474.3 Assembly Of The HIV Virion Ppia Ubap1 Tsg101 Mvb12a Mvb12b Vps37a Vps37b Vps37c Vps37d Ubc Vps28 Furin Nmt2 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility Nrg3 Memo1 Nrg1 Rhoa Egfr Diaph1 Erbb2 Egf Ereg Hbegf Btc Nrg2 Nrg4 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) Sv2c Sv2b Sv2a Vamp1 Vamp2 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity Prkaa2 Adipor2 Adipor1 Adipoq Mlxipl Prkab2 Prkag2 Stk11 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression Actl6a Smarce1 Trpm1 Actb Myo5a Cdc25b Usf1 Gmpr Cdh2 Pxn Birc7 Asah1 Pxdn Edil3 Zeb1 Tert Hdac1 Gxylt2 Tbx2 Bcl2a1d Akt2 Lig1 Tcf7l1 Tcf7l2 Mov10 Hint1 Ago4 Ago3 Ago2 Ago1 Pou3f2 Sox10 Diaph1 Brca1 Plk1 Cdkn2a Stt3b Atp6v0b Ctnnb1 Tcf7 Arid1a Arid1b Cdh1 Ccnd1 Cdk2 Met Atp6v1c1 Mcm5 Serpine1 Dct Tyrp1 Cdkn1a Tyr Mcm2 Gpr143 Atp6v1e1 Mapk14 Ss18 Mlph Atp6v1a Dpf1 Atp6v1b2 Dpf2 Rab27a Atp6v0d1 Dpf3 Mlana Atp6v0e1 Ss18l1 Lef1 Pmel Atp6v1g1 Bcl7a Bcl7b Bcl7c Irf4 Myrip Tfap2a Sytl2 Smarcb1 Atp6v1h Bcl2 Tnrc6c Tnrc6a Smarca2 Tnrc6b Smarca4 Itga2 Smarcd1 Smarcd2 Sin3a Smarcc2 Smarcc1 Sox2 Smarcd3 Dicer1 Ppargc1a Sirt1 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602571 TRAF3 deficiency - HSE Traf3 Ticam1 Tlr3 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Hey2 Hey1 Mib2 Ncor2 Skp1 Mamld1 Notch1 Rbx1 Ubc Kat2b Kat2a Cul1 Hdac2 Hdac1 Hdac5 Hdac4 Myc Hdac7 Hdac6 Hdac9 Hdac8 Ncor1 Dll4 Hes1 Jag2 Jag1 Adam10 Ep300 Cdk8 Neurl1b Tbl1x Adam17 Neurl1a Dll1 Mib1 Hdac3 Tbl1xr1 Psen1 Psen2 Ncstn Maml1 Aph1b Maml2 Heyl Hdac11 Hdac10 Hes5 Rbpj Ccnc Crebbp PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis Henmt1 Asz1 Tdrd1 Mov10l1 Tdrd12 Mybl1 Fkbp6 Piwil4 Tdrkh Piwil2 Piwil1 Tdrd9 Tdrd6 Ddx4 Mael Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Hsp90aa1 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112412 SOS-mediated signalling Irs1 Irs2 Nras Sos1 Hras INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876493 InlA-mediated entry of Listeria monocytogenes into host cells Src Ctnnb1 Cbll1 Ctnnd1 Cdh1 Ubc APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin Psma4 Psma3 Psma6 Psma5 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdc27 Ube2d1 Psmb5 Cdc16 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cdc20 Pttg1 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9613829 Chaperone Mediated Autophagy Cftr Lamp2 Cetn1 Pcnt Plin2 Gfap Rnase1 Park7 Hspa8 Ubc Hbbt1 Plin3 Hdac6 Ift88 Arl13b Hsp90aa1 Hsp90ab1 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 96%5661231 Metallothioneins bind metals Mt2 Mt1 Mt4 Mt3 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair Nthl1 Ogg1 Neil1 Neil3 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters Runx3 Myc Ctnnb1 Tcf7 Lef1 Axin2 Tcf7l1 Tcf7l2 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle Taf4 Taf3 Taf2 Taf1 Ppia Xrcc6 Nup133 Xrcc5 Chmp2a Chmp3 Chmp7 Chmp6 Chmp4c Chmp4b Ubc Polr2c Pdcd6ip Polr2d Polr2a Polr2b Polr2g Nedd4l Polr2h Polr2e Polr2f Polr2k Mnat1 Cxcr4 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Nmt2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Rnmt Ercc3 Cdk7 Rngtt Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Lig1 Nup62 Nup88 Kpna1 Aaas Nup214 Banf1 Nup210 Nup155 Nup153 Psip1 Hmga1 Ubap1 Tsg101 Mvb12a Mvb12b Vps37a Vps37b Vps37c Rcc1 Vta1 Vps37d Ranbp1 Nmt1 Ccr5 Chmp5 Vps28 Vps4a Vps4b Ran Furin Fen1 Nup37 Nup160 Nup43 Ranbp2 Cd4 Nup107 Lig4 Ell Nelfa Nelfb Nelfe Taf15 Ctdp1 Xrcc4 Taf11 Taf13 Taf12 Ccnk Tbp Taf4b Xpo1 Gtf2a1 Gtf2a2 Gtf2b Nup85 Gtf2e1 Gtf2e2 Taf9 Ncbp2 Ncbp1 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Taf8 Eloa Sec13 Taf7 Taf6 Eloc Taf5 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) Slc5a7 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME DATABASE ID RELEASE 96%9820962 Assembly and release of respiratory syncytial virus (RSV) virions Hsp90aa1 Hsp90ab1 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 96%210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism Glul Slc1a3 Slc1a2 Slc38a1 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA Mapk11 Exosc9 Exosc8 Exosc5 Dis3 Akt1 Exosc4 Exosc7 Exosc6 Parn Exosc1 Exosc3 Exosc2 Dcp2 Mapk14 Ywhaz LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 96%418889 Ligand-independent caspase activation via DCC Unc5a Dapk3 Dcc Appl1 Casp3 Maged1 Dapk1 Unc5b Casp9 Dapk2 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome Ash2l Kmt2d Rbbp5 Dpy30 Wdr5 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation Ppp2cb Usp2 Ppp2ca Trp53 Usp7 Mlst8 Rffl Mtor Atm Akt3 Cdkn2a Akt2 Akt1 Phf20 Rictor Chek2 Cdk1 Mapkap1 Sgk1 Ppp2r1b Ppp2r1a Mdm2 Ubc Cdk2 Mdm4 Ccna1 Ccna2 Daxx Rnf34 Prr5 Ppp2r5c Pdpk1 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate Taldo1 Tkt DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 96%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Ext2 Ext1 Sdc1 Gpc1 Gpc3 Gpc2 Agrn Hspg2 Gpc5 Sdc4 Sdc3 Gpc4 Sdc2 Gpc6 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 96%68877 Mitotic Prometaphase Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Nedd1 Cenpt Cenps Cenpq Actr1a Cenpp Tuba1a Ppp2r5e Cenpo Cenpn Cenpm Dctn2 Mis12 Dctn3 Nup133 Cenpl Zwilch Cenpk Cenpi Cenph Ywhae Smc1a Cenpf Cenpe Pcnt Tuba4a Cep250 Sdccag8 Cep78 Cep76 Cep72 Cep70 Tubb5 Plk4 Cep135 Cep131 Prkar2b Tubb4b Haus7 Tubb4a Haus8 Cdk5rap2 Eml4 Cep57 Pcm1 Ssna1 Tubg1 Ofd1 Cep63 Cep152 Nek9 Haus3 Nek6 Nek7 Csnk2a2 Haus4 Haus5 Haus6 Sfi1 Csnk1d Haus1 Haus2 Hsp90aa1 Firrm Cep164 Prkaca Ccp110 Alms1 Smc4 Smc2 Cetn2 Tubgcp2 Numa1 Ncaph Tubg2 Ncapd2 Nme7 Tubgcp5 Tubgcp4 Tubgcp3 Cep43 Mzt1 Mzt2 Cep41 Plk1 Ninl Cdk1 Nek2 Cpap Clasp1 Clasp2 Ywhag Pafah1b1 Smc3 Nup37 Zw10 Nup160 Cdc20 Csnk2b Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Csnk1e Bub1b Kif2a Rad21 Kif2b Kif2c Dync1li2 Pmf1 Wapl Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Stag2 Stag1 Ppp2r1b Ppp2r1a Pds5b Pds5a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Xpo1 Nuf2 Ccnb2 Nup85 Cdca8 Incenp Cdca5 Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Akap9 Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 96%5668599 RHO GTPases Activate NADPH Oxidases Nox1 Pik3c3 Prkcb Prkcd Pin1 Prkca Mapk11 Prkcz Rac2 S100a9 Rac1 S100a8 Mapk1 Mapk3 Pik3r4 Noxo1 Ncf1 Ncf2 Ncf4 Cyba Mapk14 Cybb Noxa1 Nox3 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 96%3248023 Regulation by TREX1 Trex1 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA Echs1 Acsm3 Acads Hadh CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 H2bc3 Kdm5b H2bc21 H2bc26 Mettl23 H2ab2 Aicda Kdm5a Kdm6a Stpg4 Kdm6b Uhrf1 Tet3 H2bu2 H2ac12 H2ac11 H2ac15 H3c7 H2ax Hist1h2bp Hist2h2aa1 H2aj DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.1 Defective FV causes thrombophilia Pros1 F5 Proc RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation Polr3k Polr3gl Polr2h Crcp Polr3a Polr2e Polr3d Polr2f Polr2k Polr3e Polr1c Polr3b Polr3c Polr3h Polr3f Polr1d Polr3g TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 96%933541 TRAF6 mediated IRF7 activation Sike1 Rnf135 Trim25 Mavs Rigi Irf7 Tbk1 Irf3 Traf2 Ikbke Ifnb1 Tank Crebbp Traf6 Ep300 Ifih1 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 96%9772573 Late SARS-CoV-2 Infection Events Ano7 Ano6 Ano5 Ano4 Ano2 Ano1 Magt1 Prmt1 Ace2 Tmprss2 Tmem258 Stt3a Canx Stt3b Srpk1 Srpk2 Ostc Ubc Tusc3 Furin Dad1 Parp14 Parp16 Galnt1 Ddost Parp4 Parp6 Ganab Mgat5 Gsk3a Parp8 Zdhhc9 Gsk3b Man2a1 Parp10 Parp9 Zdhhc11 Mgat2 Mgat1 Mogs Csnk1a1 Golga7 Edem2 Fut8 St6galnac3 St6galnac4 St6galnac2 St3gal4 Mgat4c Ube2i Mgat4a St3gal2 Mgat4b St3gal1 Man1b1 Zdhhc20 Prkcsh St6gal1 Zdhhc8 Zdhhc5 Rpn2 Zdhhc3 Rpn1 Zdhhc2 Ano10 Ano8 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 96%4719377 Defective DPM2 causes CDG-1u Dpm1 Dpm2 Dpm3 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 96%937041 IKK complex recruitment mediated by RIP1 Tlr4 Ube2v1 Ripk3 Ikbkb Ripk1 Ube2d3 Birc3 Ubc Birc2 Ikbkg Ticam2 Ticam1 Cd14 Ly96 Ube2d1 Traf6 Ube2n Chuk RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9820960 Respiratory syncytial virus (RSV) attachment and entry Tlr4 Cx3cr1 Rab5a Rab5c Rab5b Igf1r Sdc1 Egfr Gpc1 Gpc3 Gpc2 Furin Agrn Cd14 Hspg2 Gpc5 Sdc4 Sdc3 Ly96 Gpc4 Sdc2 Gpc6 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 96%110330 Recognition and association of DNA glycosylase with site containing an affected purine H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Tinf2 H2bc3 H2bc21 H2bc26 H2ab2 H3c8 Neil3 H2bu2 Ogg1 H2ac12 H2ac11 Acd Mpg H2ac15 H2ax Terf2ip Terf2 Hist1h2bp Terf1 Hist2h2aa1 H2aj Pot1 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-HSA-8847453.3 Synthesis of PIPs in the nucleus Pip4p1 Pip4k2b Pip4k2a O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 96%1480926 O2 CO2 exchange in erythrocytes Ca2 Hbbt1 Ca4 Cyb5rl Rhag Slc4a1 Aqp1 Cyb5r4 Cyb5r2 Ca1 Cyb5r1 Hba-a1 POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels Kcnk1 Kcnk7 Kcnk6 Kcnq4 Kcnq3 Kcnq2 Gng10 Kcnmb1 Kcnma1 Gng3 Kcnn2 Gng2 Gng4 Gng7 Gng8 Gngt1 Gngt2 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 Kcnj11 Abcc9 Kcnj3 Kcnj2 Gabbr1 Gabbr2 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Kcnh8 Kcnh7 Kcnj10 Kcnh6 Kcnh5 Kcnh4 Kcnh3 Kcnj12 Kcnh2 Kcnq5 Kcnq1 Kcnj15 Kcna7 Kcnj16 Kcna6 Kcnmb2 Kcna5 Kcna4 Kcna3 Kcna2 Kcna10 Kcna1 Kcnmb4 Kcnj1 Kcnf1 Kcng4 Kcng3 Kcng2 Kcng1 Kcnh1 Kcnd3 Kcnd2 Kcnd1 Kcnn4 Kcnn3 Kcnk13 Kcnn1 Kcnk10 Kcnk16 Kcnv2 Kcnk18 Kcnv1 Hcn3 Hcn4 Kcnb2 Kcnb1 Kcnk4 Kcnk3 Kcnk2 Kcnab1 Kcns3 Kcnab2 Kcns2 Kcns1 Kcnab3 Kcnc4 Kcnc3 Kcnc2 Kcnk9 Kcnc1 Kcnj14 Hcn1 Hcn2 Abcc8 Kcnj8 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction Mylk Gucy1a1 Myl6 Pak1 Gucy1a2 Myl7 Itgb5 Sorbs1 Pxn Myl6b Pak2 Anxa1 Sorbs3 Tln1 Vcl Pde5a Itga1 Aldh2 Myl12a Cacna1g Myl12b Cacna1h Anxa6 Myh11 Anxa2 Myl10 Gucy1b1 Trim72 Lmod1 Cacna1i Mylpf Cav3 Tpm3 Tpm2 Dysf CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 Erbb2 Shc1 Cdc37 Erbin Nras Ptpn12 Sos1 Hsp90aa1 Hras RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Tnfrsf18 Il2 Nfatc2 Il2ra Ifng Foxp3 Cbfb Ctla4 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA Hadha Hadhb Acadvl DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 96%4793954 Defective MOGS causes CDG-2b Mogs DEFECTIVE GALE CAUSES EDG%REACTOME%R-HSA-5609977.5 Defective GALE causes EDG Gale MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation Tnip2 Fbxw11 Map2k4 Btrc Map2k1 Ikbkb Ubc Ikbkg Map3k8 Nfkb1 Skp1 Cul1 Chuk NEF AND SIGNAL TRANSDUCTION%REACTOME%R-HSA-164944.6 Nef and signal transduction Fyn Rac1 Lck Elmo1 Hck Pak2 Dock2 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins Galnt3 Muc15 Muc13 Pomgnt1 Galnt12 Adamts1 Adamts5 Adamts4 Adamts3 Adamts2 Adamts8 Adamts7 Adamts6 Sema5a Sema5b C1galt1 Thsd1 Thbs2 C1galt1c1 Thsd4 Adamts13 Adamts14 Adamts15 Large1 Adamts16 Cfp Adamts18 Notch1 Adamts19 Spon2 Muc1 Spon1 Adamts10 Sbspon Adamts12 B3glct Muc4 Muc6 Thsd7a Muc20 Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Pomt1 Adamts20 Dag1 Thsd7b Lfng Pomt2 Notch4 Notch2 Notch3 B4gat1 Thbs1 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 96%397795 G-protein beta:gamma signalling Pak1 Plcb3 Plcb2 Plcb1 Gng10 Rhoa Akt3 Gng3 Akt2 Gng2 Akt1 Arhgef6 Gng4 Btk Gng7 Gng8 Gngt1 Gngt2 Pik3cg Gnb2 Gnb1 Gnb4 Gnb3 Pik3r5 Gnb5 Pdpk1 Pik3r6 Gng11 Gng12 Gng13 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants Fgfr2 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification Acy3 Mgst3 Mgst2 Cyp1a2 Mgst1 Cyp2a5 Ggt1 Acy1 Cyp3a16 Dpep1 Dpep2 Ggt7 Ggt5 Akr7a2 Ggt6 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events Rasgrp1 Trio Anxa1 App Mgll Btk Gna11 Gna15 Gna14 Gnaq Cysltr2 Ednra Cysltr1 Npff Trhr Rgsl1 Gng10 Gnrh1 Nmbr Fpr2 Ptgfr Agtr1a Gcgr Nmb Lpar6 Xcr1 Lpar5 Ppan Grpr Gpr17 Gng3 Nms Gng2 Nmu Cckar Nmur2 Gng4 Gnrhr Plcb4 Nmur1 Gng7 Ntsr2 Ntsr1 Brs3 Gng8 Ptger1 Gpr132 Edn2 Cckbr F2 Hcrt Grp Kiss1r Gngt1 Nps Gngt2 Ptafr Npffr1 Npffr2 Gprc6a Prok2 Gpr4 Qrfp Prok1 Npsr1 Gcg Agt P2ry10 F2rl1 Gast F2rl2 F2rl3 Gnb2 Prokr2 Ghsr Gnb1 Prokr1 Gnb4 Rgs4 Gnb3 Rgs5 Gnb5 Gng11 Rgs2 Rgs3 Gng12 Gpr65 Gng13 Rgs1 Gpr68 Uts2 Tacr1 Tacr3 Tacr2 Casr F2r Ffar3 Itpr3 Ffar4 Itpr2 Bdkrb2 Itpr1 Ffar1 Mapk7 Bdkrb1 Ffar2 Nts Kng2 Grk5 Tac3 Tac1 Opn4 Pmch Ltb4r1 Ltb4r2 Hbegf Trh Grm1 Grm5 Lpar4 Lpar3 Lpar2 Lpar1 Mmp3 Qrfpr Xcl1 Kiss1 Rgs21 Rgs17 Rgs18 P2ry6 Rgs19 Rgs13 P2ry2 Rgs16 P2ry1 Hcrtr2 Hcrtr1 Uts2b Cck Uts2r Egfr Rps6ka3 Rps6ka2 Saa3 Grk2 Prkcd Trpc6 Trpc7 Trpc3 Oxtr Avpr1b Avpr1a Oxt Avp Prkcq Rasgrp2 Plcb3 Ednrb Plcb2 Plcb1 Prkca Daglb Dgka Edn1 Dgkb Edn3 Abhd6 Dgke Abhd12 Dgkg Dgkh Dgki Dgkk Rps6ka1 Mchr1 Dgkq Prkch Dgkz Dagla Prkce Arhgef25 Pik3r1 Pik3r2 Adra1b Adra1a Adra1d Tbxa2r Pik3ca Mapk1 Mapk3 Gpr143 Chrm1 Hrh1 Chrm3 Chrm5 Htr2a Nras Htr2c Htr2b Sos1 Hras Kalrn GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 96%202433 Generation of second messenger molecules Cd3g Vasp Cd3e Cd3d Pak1 Lck Pak3 Pak2 Plcg1 Zap70 H2-Eb1 Grap2 Itk Cd4 Fyb1 Plcg2 Cd101 Nck1 Lcp2 Lat Evl Was MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 96%975155 MyD88 dependent cascade initiated on endosome Tlr4 Mapk9 Mapk7 Mapk8 Irf7 App Ikbkb Jun Peli1 Elk1 Ikbkg Map3k7 Ticam2 Traf2 Ticam1 Cd14 Map3k8 Nfkb1 Skp1 Fbxw11 Rela Btrc Casp8 Ubc Mapk1 Nfkbib Mapk3 Rps6ka3 Irak1 Nfkbia Mapkapk3 Rps6ka2 Traf6 Mapkapk2 Cul1 Ube2n Map2k7 Mapk14 Chuk Map2k6 Ppp2cb Ppp2ca Ube2v1 Trp53 Map2k4 Tab3 Map2k3 Tab2 Tab1 Mapk10 Map2k1 Mapk11 Ripk2 Myd88 Rps6ka5 Tlr9 Nkiras1 Atf2 Nkiras2 Rps6ka1 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Peli2 Ppp2r1a Peli3 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Tifa Dusp6 Alpk1 Irak2 Ager Nlrx1 Nfkb2 Mef2a Usp14 Usp18 Fos Tlr7 Ppp2r5d Ly96 Mef2c DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.3 Defective F8 cleavage by thrombin F2 Vwf F8 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9759811 Regulation of CDH11 mRNA translation by microRNAs Tnrc6c Ago4 Ago3 Ago2 Ago1 Tnrc6a Tnrc6b Cdh11 Mov10 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization Pik3ca Fyn Lat2 Syk Pdpk1 Pik3r1 Pik3cb Sos1 Pik3r2 Lyn Gab2 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress Cdkn2a Cdk6 Cdk4 SUCCINYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9853506 Succinyl-CoA Biosynthesis Ogdh Dlst Dld DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism Bckdhb Bckdk Bckdha Dbt Dld Acat1 Echs1 Hibch Mccc1 Auh Ivd Mccc2 Ppm1k SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants Arrb1 Jak2 Fgb Fga Rap1b Map2k2 Ksr1 Vwf Cnksr2 Nras Cnksr1 Fgg Map2k1 Araf Mark3 Itgb3 Raf1 Hras Tln1 Fn1 Vcl Csk Itga2b Src Camk2g Camk2d Camk2b Camk2a Mapk1 Braf Mapk3 Ywhab Rap1a Apbb1ip Arrb2 Iqgap1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 96%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Notch1 Rbx1 Skp1 Cul1 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 96%69091 Polymerase switching Pcna Rfc4 Prim2 Rfc1 Prim1 Rfc2 Pola2 Pold4 Pola1 Pold3 Rfc5 Pold2 Pold1 Rfc3 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Gata1 Prmt6 Prmt1 H2bc9 Nfe2 H2bc7 H2bc8 Gp1ba H2bc3 H2ab2 Nr4a3 H2bu2 Cbfb Pf4 Kat2b Kmt2c Hist2h2aa1 Dpy30 Wdr5 Prkcq Kmt2d Kmt2b H2bc14 H2ac20 Hdac1 Setd1b Itga2b H2bc21 Tnrc6c Setd1a H2bc26 Rbbp5 Tnrc6a Tnrc6b Ep300 Mov10 H2ac12 H2ac11 Sin3a Ago4 Sin3b Ago3 Ago1 H2ac15 H3c7 H2ax Myl12a Ash2l Hist1h2bp H2aj Zfpm1 Thbs1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer Smad2 Smad3 Smad4 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression Trp53 Prdm1 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 96%9762292 Regulation of CDH11 function Jup Angptl4 Cdh8 Adam19 Adam33 Cdh24 Ctnnb1 Ctnna1 Ctnnd1 Cdh11 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex Tab3 Tab2 Map3k7 Ticam1 Tab1 Tlr3 Traf6 Ubc LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69186 Lagging Strand Synthesis Pcna Rfc4 Rpa2 Prim2 Rfc1 Prim1 Rfc2 Pola2 Pold4 Pola1 Pold3 Rpa3 Dna2 Lig1 Fen1 Rfc5 Pold2 Pold1 Rfc3 Rpa1 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants Ppp2cb Ppp2ca Gsk3b Ctnnb1 Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL Yes1 Cbl Rapgef1 Pik3cb Blnk Crk Pik3cd Pik3ca Fyn Syk Vav1 Crkl Hck Pik3r1 Pik3r2 Lyn GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation Proc Arsb F8 Pros1 Gas6 Furin Tpst1 Tpst2 Riox1 Riox2 Kdm8 Dhps Eif5a Rwdd1 Fn3k Fn3krp Proz F7 Eif5a2 Jmjd4 F9 Jmjd6 Sumf1 Sumf2 Arsa Icmt Dohh Rccd1 Ggcx Dph1 Dph2 Dph3 Etf1 Dnajc24 Dph5 Dph6 Eef2 Dph7 Zc3h15 F10 Ogfod1 Arsk Arsj Drg1 F2 Arsi Drg2 Arsg Asph NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR Ngf Ngfr HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450520 HuR (ELAVL1) binds and stabilizes mRNA Tnfsf13 Anp32a Prkcd Elavl1 Prkca Nup214 Xpo1 HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation Dohh Dhps Eif5a Eif5a2 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 96%9694493 Maturation of protein E Ubc REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade C1qc C3ar1 Vtn F2 Elane Cr2 Serping1 Cfh C5ar2 Cfi C5ar1 Clu C6 C7 C9 Cd59b Cd46 Cfhr1 Cfhr2 Pros1 Cd81 C8b C3 C8a Cpn1 C4a C5 Cpn2 C8g Cfb C1qb C2 Cd19 C1qa Cpb2 C1rb C1s2 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856828 Clathrin-mediated endocytosis Arfgap1 Tor1b Necap2 Necap1 Scarb2 Sgip1 Bin1 Itsn2 Hip1r Dab2 Agfg1 Grk3 Snx9 Amph Snap91 Pik3c2a Syt9 Syt8 Tgfa Actr2 Aak1 Arpc1a Synj2 Actr3 Gapvd1 Ap2m1 Ldlrap1 Picalm Snx18 Syt11 Slc2a8 Ubqln2 Epn2 Dvl2 Ubqln1 Epn1 Gak Il7r Avpr2 Arpc3 Arf6 Arpc2 Lrp2 Ap2a2 Ston2 Eps15l1 Ap2a1 Pacsin1 Arpc5 Avp Trip10 Arpc4 Cttn Ldlr Pacsin3 Pacsin2 Reps2 Pip5k1c Ubc Ap2b1 Wnt5a Ap2s1 Dnm1 Dnm3 Wasl Agtr1a Hip1 Synj1 Cftr Slc18a3 Fzd4 Fnbp1 Fnbp1l Arrb2 Tacr1 Cd3g Arrb1 Cd3d Ereg Clta Hbegf Btc Cltc Epgn Cops4 Cops3 Cops6 Cops2 Dnajc6 Cops8 Stam2 Sh3gl3 Cltb Cops7a Sh3kbp1 Stam Cops7b Vamp7 Eps15 Vamp8 Rab5a M6pr Rab5c Cbl Hgs Rab5b Dnm2 Sh3gl1 Hspa8 Sh3gl2 Egfr Cops5 Tf Ocrl Igf2r Chrm2 Tfrc Vamp4 Adrb2 Cd4 Nedd8 Egf Areg Syt2 Syt1 Vamp2 Grk2 Vamp3 Itsn1 Fcho1 Fcho2 D130043K22Rik Tor1a Apob SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 96%1614517 Sulfide oxidation to sulfate Tstd1 Ethe1 Sqor Tst Suox Slc25a10 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones Sap30l Suds3 Brms1 Rcor1 Sap30 H2bc9 Sap18b H2bc7 H2bc8 Arid4b H2bc3 Arid4a Ncor2 Hmg20b Gatad2a Gatad2b Kdm1a Mbd3 H2bu2 Mta1 Gps2 Mta3 H2bc18 Hist2h2aa1 H2bc14 H2ac20 Hdac2 Hdac1 H2bc21 H2bc26 Rbbp4 Hdac8 Ncor1 Rbbp7 Tbl1x Chd3 Chd4 H2ac12 H2ac11 Hdac3 H2ac15 H2ac21 H3c7 H2ac25 Tbl1xr1 Hist1h2af Rest H2ac1 Mta2 Hist1h2bp Hdac10 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 96%9856872 Malate-aspartate shuttle Slc25a12 Slc25a13 Got1 Got2 Mdh1 Mdh2 Slc25a18 Slc25a11 Slc25a22 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9692912 SARS-CoV-1 targets PDZ proteins in cell-cell junction Pals1 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 96%177135 Conjugation of benzoate with glycine Glyatl3 Glyat Acsm1 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription Cited2 Foxo4 Foxo1 Abca6 Sod2 Bcl2l11 Pcbp4 Fasl Btg1 Txn Foxo3 Ccng2 Npy Srebf1 Mstn Agrp Gck Kat2b Cdkn1a Cdkn1b Plxna4 Fbxo32 Ywhab Atxn3 Ywhag Sirt3 Nr3c1 G6pc1 Smad2 Smad3 Smad4 Hdac2 Hdac1 Stk11 Foxg1 Rbl2 Akt3 Akt2 Trim63 Akt1 Ep300 Ywhaz Bcl6 Cat Sin3a Pomc Gadd45a Igfbp1 Pink1 Cav1 Nfyb Sfn Nfya Ddit3 Nfyc Ppargc1a Txnip Klf4 Retn Crebbp Ins2 Sirt1 Pck1 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint Trp53 Psma4 Psma3 Psma6 Psma5 Plk1 Psma2 Psma1 Psmd12 Mapre1 Psmd11 Psmd14 Psmd13 Cdk1 Psmb5 Psmb4 Psmb7 Psmb6 Hsp90ab1 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Ccnb2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Fkbpl Psmd6 Gtse1 Cdkn1a Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Hsp90aa1 Sem1 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex Chmp2a Map1lc3b Becn1 Pik3r4 Uvrag Pik3c3 Chmp4c Iscu Chmp4b Chmp3 Chmp7 Chmp6 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 96%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) Slc2a9 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%774815 Nucleosome assembly Cenpc1 Itgb3bp Knl1 Cenpu Cenpt Cenps H2bc14 Cenpq H2bc9 Cenpp H2bc7 H2ac20 H2bc8 Cenpo Cenpn H2bc3 Cenpm Cenpl H2bc21 Cenpk H2bc26 Cenpi Cenph Rbbp4 Ruvbl1 Rbbp7 H2ab2 H2bu2 H2ac12 H2ac11 Npm1 H2ac15 Smarca5 H2ax Hist1h2bp Hist2h2aa1 Cenpa H2aj Rsf1 Oip5 Mis18a Cenpx Cenpw Mis18bp1 VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.5 Virus Assembly and Release Canx Calr ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 96%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H2bu2 H2ac12 H2ac11 H2ac15 Ncoa2 H3c7 H2bc14 H2ax H2bc9 Pkn1 H2bc7 H2ac20 H2bc8 Ar H2bc3 H2bc21 Hist1h2bp H2bc26 Hist2h2aa1 H2aj H2ab2 Kdm1a Kdm4c FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839126.4 FGFR2 mutant receptor activation Fgf16 Fgf18 Fgf2 Fgf1 Fgf4 Fgf10 Fgf3 Fgf6 Fgf7 Fgf9 Fgf20 Fgf23 Fgf22 Fgfr2 Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9033241 Peroxisomal protein import Usp9x Pex2 Ube2d1 Pex14 Pex13 Pex12 Pex10 Acot8 Hsd17b4 Ehhadh Acaa1a Hmgcl Slc27a2 Decr2 Acot4 Gnpat Ube2d3 Ubc Lonp2 Dhrs4 Idh1 Phyh Amacr Mpv17 Ide Hacl1 Gstk1 Pex26 Crot Scp2 Paox Crat Acox1 Acox2 Nudt19 Ech1 Acot2 Acox3 Pex1 Pex7 Pex6 Pipox Tysnd1 Baat Ddo Zfand6 Agps Hao1 Agxt Hao2 Nudt7 Pecr Nos2 Dao Cat Ephx2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%R-HSA-982772.3 Growth hormone receptor signaling Jak2 Irs1 Socs2 Irs2 Prlr Ghr Cish Ptpn6 Stat5a Stat5b Mapk1 Ptpn1 Stat3 Mapk3 Stat1 Socs3 Prl Socs1 Lyn Adam17 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112307 Transmission across Electrical Synapses Gjd2 Gjc1 Panx2 Panx1 INFECTIOUS DISEASE%REACTOME DATABASE ID RELEASE 96%5663205 Infectious disease Tlr4 Fkbp1a Sap30l Ppia Suds3 Brms1 Rcor1 Jak3 Sap30 Tyk2 Sap18b Blnk Arid4b Jun Crbn Arid4a Cd79a Cd79b Ifnar1 Hmg20b Ap2m1 Ifngr2 Ifngr1 Ywhae S1pr1 Sigmar1 Fnta Fntb Stat2 Il1r1 Sympk Prkacb Cstf1 Papola Clp1 Nudt21 Ap2a2 Cpsf1 Cstf2 Ap2a1 Cpsf2 Cstf3 Cpsf3 Cstf2t Wdr33 Hdlbp Rbx1 Ap2b1 Wnt5a Ap2s1 P4hb Gng10 Gng3 Gng2 Hspg2 Gng4 Sdc4 Sdc3 Gng7 Sdc2 Gng8 Gngt1 Gngt2 Fzd7 Sdc1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 Cul3 Cdc73 Rtf1 Gpc1 EG433182 Gpc3 Leo1 Gpc2 Skic8 Gpc5 Gpc4 Gpc6 Ctr9 Paf1 Tyro3 Mapre3 Rb1 Mrc1 Emc4 Timd4 Cldn1 Mertk Rnasek Cd300a Axl Hspa5 Pros1 Ly6e Daxx Gas6 Agrn Nup37 Nup160 Nup43 Ranbp2 Dync1li2 Dync1li1 Nup107 Dynll1 Dynll2 Rps27 Dync1h1 Tkfc Nup85 Dync1i2 Dync1i1 Sec13 Ano10 Ano8 Ano7 Ppp1cc Taok1 Ano6 Ano5 Ano4 Ano2 Ano1 Nup133 Traf3 Cd14 Ikbke Hnrnpu Mta1 Tjp1 Mta3 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Parp14 Gtf2h1 Parp16 Nmt2 Gtf2f2 Galnt1 Gtf2h4 Parp4 Gtf2f1 Parp6 Gtf2h3 Supt5h Gsk3a Parp8 Gtf2h5 Parp10 Ercc2 Ccnh Parp9 Rnmt Ercc3 Cdk7 Rngtt H2ac20 Prkg2 Akt3 Akt2 Akt1 Prkar1a Rpn2 Rpn1 Lyn Yes1 H2ac12 H2ac11 Vps36 Ubap1 H2ac15 Tsg101 Mvb12a H3c7 Mvb12b Ezh2 Vps37a Vps37b Vps37c Csnk2a2 Rcc1 Vta1 Ranbp1 Vps37d Suz12 Cd28 Snf8 Nmt1 Vps25 Nfkb2 Ccr5 Chmp5 Vps28 Rac1 Vps4a Hist1h2bp Vps4b Jak1 Vav1 Pik3r1 Cd3g Magt1 Pak2 Brd4 H2bc9 Tufm H2bc7 H2bc8 H2bc3 Tmem258 Stat1 Rictor Nek2 Ifih1 H2bu2 Sike1 Rnf135 Trim25 Mavs Stt3a Rigi Stt3b Srpk1 Srpk2 Vcp Cx3cr1 Rab5a Ostc Rab5c Rab5b Igf1r Tusc3 Hist2h2aa1 Prr5 Dad1 Ywhag Pdpk1 Ddost Csnk2b Eed Gsk3b Lck Mlst8 Csnk1a1 H2bc14 Ptpn6 Pdcd1 Mtor Cd4 Ptpn11 Fyn Cd209a H2bc21 H2bc26 Rbbp4 Rbbp7 Mapkap1 Rab7 Ell Nelfa Nelfb Nelfe Taf15 Ctdp1 Taf11 Taf13 Taf12 Ccnk Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Taf9 Ncbp2 Ncbp1 Itgb1 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Taf8 Eloa Taf7 Taf6 Eloc Dock1 Dock2 Taf5 Taf4 Elmo2 Taf3 Taf2 Taf1 Gja1 Cyfip1 Ppp1ca Ppp1cb Actb Ptk2 Cxcr4 Nrp1 Pabpc1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nck1 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Kpna1 Aaas Nup214 Banf1 Nup210 Nup155 Myo9b Nup153 Slc25a5 Prkar2a Psip1 F2 Slc25a4 Hmga1 Dpm1 Rps14 Dpm2 Rpl4 Dpm3 Rps16 Rps18 Rps19 Eif2ak2 Rpsa Rpl37 Rpl39 Rps10 Kpnb1 Rps11 Rpl7 Hsp90aa1 Ipo5 Rpl32 Rps9 Rps7 Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Mlkl Grsf1 Tgfb1 Rps25 Rps26 Kpna4 Kpna7 Rps21 Kpna3 Cpsf4 Rpl39l Havcr1 Ace2 Isg15 Rps15a Tmprss2 Elk1 Dnajc3 Clta Hbegf Parp1 Cltc Calr Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Hspa1a Rpl17 Arf1 Rpl18 Rpl19 Rpl10l Rpl11 Canx Rps3 Rps4x Pabpn1 Ran Hspa8 Comt Fasn Pik3c3 Rnps1 Srsf1 Srsf9 Cdc40 Srsf7 Srsf6 Tlr9 Pik3r4 Srsf3 Srsf2 Srsf11 Srrm1 Alyref Dhx38 U2af1l4 Il6ra Eif4a3 Elavl1 Rnf213 Clu Ube2l6 Atg7 Keap1 Vtn Ap1m2 Ap1m1 Pacs1 Ap1s3 Ap1s2 Ap1b1 Ap1s1 Ap1g1 B2m H2-Q10 H2bc18 Map1lc3b Becn1 Uvrag Iscu Ubr4 Traf6 Ube2n Uba5 Uba6 Uba7 Ube2v1 Tab3 Tab2 Tab1 Ywhah Hdac1 Acot2 Uba1 Uba3 Cul5 Ywhaz Nos2 Il17rc Il17ra Phf5a Vps39 Hyou1 Crnkl1 Med9 Vps18 Vps11 Vps16 Btf3 Cdk19 Med13l Cav1 Dnajb11 Map1b Xab2 Aup1 Ipo7 Hnrnpa2b1 Zcrb1 Prpf19 Bag2 P4ha1 P4ha2 Vav3 P4ha3 Puf60 Hnrnpul1 Impdh1 Vps41 Cd209d Vps45 Bcas2 Vhl Gpkow Vav2 Smndc1 Aqr Pcbp2 Pcbp1 Grpel1 Hnrnpr Clint1 Nmi Sugp1 Hnrnpd Hnrnpf Hnrnpk Ccar1 Hnrnpl Hnrnpm Tlr1 Tlr6 Tlr2 Arih1 Rbmx Sftpd Actg1 Hnrnph2 Hnrnph1 Cwc22 Sec11c Sec11a Hsp90ab1 Cwc27 Cpsf7 Hnrnpc Cwc25 Cwc15 Cbx1 Coro1a Rock2 Rbm5 Vps33a Rock1 Vps33b Txnl4a Vim Oas2 Ltf Dusp16 Gbp2 Gbp3 Rrbp1 Snrnp200 U2surp Crb3 Patj Gbp9 Snrpb2 Pals1 Tomm70 Snrpa1 Furin Ptbp1 Kdelr1 Med22 Med21 Med28 Med29 Rptor Brk1 Med11 Med19 Med18 Eif4g1 Atl2 Noxa1 Sf3a1 Sf3a2 Sf3a3 Pgk1 Baiap2 Dnajc10 Bcap31 Sf3b1 Nckap1l Sf3b2 Sf3b3 Sf3b4 Sf3b5 Sf3b6 Nlrp12 Ctnnbl1 Rcan3 Srrt Snrnp40 Eftud2 Nckap1 H2-M5 H2-M3 Eif4e Snrpn G3bp1 G3bp2 Wasf2 Stx1b Sv2c Cherp Wasf1 Noxo1 Fus Syt2 Snap25 Chmp1a Sv2b Isy1 Cdc5l Syt1 Sv2a Plrg1 Vamp1 Hnrnpa3 Cyba Vamp2 Abi2 Ppil6 Abi1 Ppil4 Stx1a Cebpd Ppil3 H2-Q1 Nox1 Hnrnpa1 Hnrnpa0 Ppil1 Nherf4 Prcc Cnbp Rbm10 Sar1b Elavl2 Bst2 Ufd1 Dhx16 Sec23a Dhx15 Nploc4 Scap Retreg1 Srrm2 Spcs3 Spcs1 Spcs2 Il17f Il17a Pex19 Prpf6 Elmo1 Hck Pdia3 Cd8b1 Ppig Sec24d Ppih Sec24c Ppie Ppib Prpf8 Sec24b Wbp11 Rtn3 Sec24a Pqbp1 Sp1 Clec5a Dnajc8 Upk1a Ddx3x Epcam Sfpq Sun2 Larp1 Rbm22 Mmp9 Adora2b Rbm17 Entpd1 Ddx46 Nt5e Ddx42 Entpd5 Dnaja2 C3ar1 Eif4g2 Ggt1 Eif4g3 Il18 Prkx Cd2bp2 Plcg2 Ddx23 Wipf3 Eif4e3 Arpc1b Actr2 Chmp2a Arpc1a Actr3 Wipf2 Wipf1 Btk Dpep1 Dpep2 Chmp3 Dvl1 Dvl2 Chmp7 Dvl3 Chmp6 Myo5a Ggt5 Arpc3 Arpc2 Nlrp3 Pstpip1 Cyfip2 Arpc5 Arpc4 Itch Ctsg Ripk3 Adcy3 Chmp4c Adcy4 Chmp4b Adcy1 Adcy2 Adcy7 Casp4 Adcy8 Casp1 Adcy5 Ripk1 Adcy6 Gnaz Fcgr1 Pdcd6ip Gsdmd Adcy9 Fcgr3 Il1a Fcgr4 Il1b Syk Mefv Fgr Myh2 Gnai2 Gnai1 Gnai3 Myo1c Nckipsd Prkar1b Was Wasf3 Pycard Gnat3 Prkar2b Cysltr2 Cysltr1 Wasl Sugt1 P2rx7 P2rx4 Myo10 Trim27 Lig1 Atp1a2 Fxyd4 Atp1a1 Fxyd1 Atp1a3 Fxyd7 Fxyd6 Camk2g Camk2d Ahcyl1 Camk2b Camk2a Atp1b1 Atp1b3 Atp1b2 Cd9 Prkaca Itpr3 Itpr2 Itpr1 Mapk8 Txn Il6 Ifnb1 Map2k7 Map2k4 Plcg1 Ripk2 Bcl2l1 Eef2 Adam17 Gemin7 Gemin4 Nod2 Gemin5 Nod1 Snrpb Smn1 Snrpd2 Snrpd1 Irak2 Snrpd3 Gemin2 Ddx20 C3 C4a Gucy2c Exoc1 Tubb5 Ganab Mgat5 Zdhhc9 Man2a1 Zdhhc11 Mgat2 Mgat1 Mogs Golga7 Edem2 Fut8 St6galnac3 St6galnac4 St6galnac2 St3gal4 Mgat4c Mgat4a St3gal2 Mgat4b St3gal1 Man1b1 Zdhhc20 Prkcsh St6gal1 Zdhhc8 Zdhhc5 Zdhhc3 Zdhhc2 Rhbdf2 Il10 Cd163 Plk2 Myh9 Txnip Med8 Med4 Med6 Gbf1 Gatad2a Gatad2b Tal1 Gps2 Cog1 Itga4 Abl1 Cdk8 Pml Xrn1 Havcr2 Kdm1a Ddx5 Fkbp4 Nedd4l Irak1 Ybx1 Trim28 Sfn Med23 Med24 Med25 Med20 Med26 Med27 Med12 Med13 Med14 Med10 Med15 Med16 Med17 Ncor2 Mbd3 Egfr Fen1 Med30 Med31 Hdac2 Eif4a2 Eif4a1 Nrbp1 H2ac21 H2ac25 Hist1h2af H2ac1 Tlr8 Tlr7 Tlr3 Ccnc C1qa C1s2 Mbl2 Cgas Sting1 Prmt1 Irf7 Psma4 Dhx9 Ikbkb Psma3 Psma6 Psma5 Xrcc6 Psma2 Xrcc5 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rela Npm1 Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Nfkbib Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Chuk Nr3c1 Smad3 Smad4 Ube2i Txnrd1 Chd3 Chd4 Rest Mta2 Jak2 Stam2 Sh3gl3 Src Sh3kbp1 Stam Ctnnb1 Eps15 Cbll1 Cbl Hgs Ctnnd1 Cdh1 Fip1l1 Sh3gl1 Sh3gl2 Met Mapk1 Mapk3 Ywhab Mapk14 Map2k2 Map2k1 Sos1 Crk Atp6v1h Tbk1 Zbp1 Irf3 Ncor1 Ep300 Tbl1x Lig4 Hmox1 Xrcc4 Hdac3 Xpo1 Tbl1xr1 Hba-a1 Hbbt1 Med1 Nfe2l2 Ly96 Crebbp Apoa1 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME DATABASE ID RELEASE 96%3656237 Defective EXT2 causes exostoses 2 Ext2 Ext1 Sdc1 Gpc1 Gpc3 Gpc2 Agrn Hspg2 Gpc5 Sdc4 Sdc3 Gpc4 Sdc2 Gpc6 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%8939247 RUNX1 regulates transcription of genes involved in interleukin signaling Lifr Elf1 Cbfb BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins Alox12 Alox5 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis Elac2 Ang Dicer1 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%156584 Cytosolic sulfonation of small molecules Sult1e1 Sult1a1 Abhd14b Sult1b1 Podxl2 Bpnt2 Sult6b1 Sult4a1 Sult2a1 Tpst1 Bpnt1 Tpst2 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex Cdc73 Rtf1 Leo1 Skic8 Aff4 Supt6 Iws1 Mllt3 Mllt1 Ctr9 Eaf1 Paf1 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Ell Nelfa Nelfb Nelfe Ctdp1 Ccnk Ncbp2 Ncbp1 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Eloa Eloc SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 96%1300642 Sperm Motility And Taxes Catsperg1 Kcnu1 Catsper4 Catsper2 Hvcn1 Catsper3 Catsper1 Catsperd Catsperb RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013419 RHOT2 GTPase cycle Rhot2 Rap1gds1 Mfn1 Mfn2 Trak2 Trak1 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%8875878 MET promotes cell motility Rap1b Gab1 Rapgef1 Crk Lama5 Lamb2 Lama1 Lamc3 Lamb3 Lama2 Lama3 Lama4 Lamc1 Lamb1 Itga3 Lamc2 Itga2 Src Tns4 Tns3 Dock7 Hgf Met Rac1 Itgb1 Ptk2 Crkl Rap1a SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation Nup133 Ikbkg Smc1a Ikbke Hic1 Sp3 Ddx5 Foxl2 Satb2 Rela Npm1 Mta1 Smc6 Smc5 Topors Ddx17 Nsmce4a Casp8ap2 Eid3 Uhrf2 Mrtfa Senp1 Senp2 Nsmce1 Nsmce3 Cbx5 Nsmce2 Nfkbia Uba2 Sae1 Safb Top2b Top2a Top1 Senp5 Nr3c2 Mbd1 Nr3c1 Satb1 Trp53 Thrb Nop58 Nr2c1 Vdr Sumo3 Nr1h2 Rora Ppara Mitf Esr1 Pparg Pias3 Nup93 Pias4 Nup50 Nup35 Ar Trim27 Rxra Nup54 Hdac1 Pom121 Hdac4 Nup205 Ube2i Nup188 Rara Pgr Tpr Rae1 Nr5a1 Pias1 Ndc1 Nup42 Nr4a2 Nup62 Nup88 Aurka Trim28 Aaas Nup214 Nup210 Nup155 Nup153 Chd3 Pcna Mdc1 Park7 Suz12 Blm Nfkb2 Eif2ak2 L3mbtl2 Wrn Herc2 Rpa1 Cetn2 Vhl Brca1 Cdkn2a Hnrnpk Ncor2 Parp1 Pcgf2 Xpc Ring1 Ing2 Cbx8 Phc2 Hnrnpc Hipk2 Phc1 Cbx4 Cbx2 Phc3 Mdm2 Daxx Bmi1 Ctbp1 Smc3 Nup37 Nup160 Rnf2 Nup43 Ranbp2 Rad21 Tfap2c Hdac2 Tfap2b Nup107 Hdac7 Trp53bp1 Nrip1 Stag2 Rnf168 Stag1 Ep300 Rad52 Xrcc4 Sin3a Birc5 Dnmt3a Dnmt3b Ncoa2 Dnmt1 Ncoa1 Nup85 Cdca8 Incenp Aurkb Ppargc1a Crebbp Pml Sec13 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 96%5654708 Downstream signaling of activated FGFR3 Fgf16 Frs2 Fgf18 Fgf2 Fgf1 Nras Gab1 Fgf4 Plcg1 Frs3 Sos1 Fgf9 Hras Fgf20 Ptpn11 Pik3ca Fgf23 Pik3r1 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 96%9008059 Interleukin-37 signaling Sigirr Il18bp Ptpn7 Ptpn9 Ptpn2 Smad3 Ptpn5 Ptpn18 Ptpn6 Il18r1 Ptpn12 Ptpn23 Casp1 Ptpn20 Ptpn13 Ptpn14 Ptpn11 Ptpn4 Tbk1 Stat3 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME DATABASE ID RELEASE 96%442729 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde Camk2b Camkk1 Camkk2 Camk2g Camk4 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade Tlr4 App Ikbkb Jun Peli1 Ikbkg Map3k7 Traf2 Cd14 Btk Nfkb1 Socs1 Skp1 Fbxw11 Rela Btrc Casp8 Ubc Nfkbib Irak1 Nfkbia Cul1 Traf6 Ube2n Chuk Ube2v1 Trp53 Tab3 Sigirr Tab2 Tab1 S100a1 Irak3 Cd36 Tirap Rps6ka1 Tifa Alpk1 Nfkb2 Fos Fgb Fga Mapk9 Mapk7 Fgg Mapk8 S100a9 Elk1 S100a8 Tlr1 Tlr6 Tlr2 Map3k8 Mapk1 Mapk3 Rps6ka3 Mapkapk3 Rps6ka2 Mapkapk2 Map2k7 Mapk14 Map2k6 Ppp2cb Ppp2ca Map2k4 Map2k3 Mapk10 Map2k1 Mapk11 Ripk2 Myd88 Rps6ka5 Nkiras1 Atf2 Nkiras2 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Ppp2r1a Peli2 Peli3 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Usp18 Ppp2r5d Ly96 Mef2c MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease Exosc9 Exosc8 Skic3 Exosc5 Dcps Dis3 Exosc4 Hbs1l Skic2 Skic8 Exosc7 Nt5c3b Exosc6 Exosc1 Exosc3 Exosc2 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 96%3214841 PKMTs methylate histone lysines Eed Kmt2d Kmt2b Setd1b Setd1a Rbbp5 Rbbp4 Ehmt2 Suv39h1 Rbbp7 Suv39h2 Ehmt1 Smyd3 Nfkb1 Setd3 Nsd3 Setd2 Kmt5c Nsd2 Setd7 Setdb2 Setd6 Setdb1 Nsd1 Aebp2 Mecom Rela Prdm9 Dot1l Atf7ip Ash1l H3c7 Prdm16 Ezh2 Suz12 Kmt5a Nfkb2 Ash2l Kmt2c Smyd2 Dpy30 Wdr5 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-HSA-1614558.10 Degradation of cysteine and homocysteine Tstd1 Got2 Ethe1 Fmo1 Tst Cth Gadl1 Cdo1 Slc25a10 Mpst Sqor Suox Ado Txn2 Csad METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 96%1237112 Methionine salvage pathway Got1 Apip Enoph1 Adi1 Mri1 Mtap CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME%R-HSA-9711123.6 Cellular response to chemical stress Sp1 Cox8a Cox7b Prdx2 Psma4 Psma3 Nox4 Psma6 Prdx1 Psma5 Psma2 Psma1 Sod2 Psmd12 Psmd11 Psmd14 Psmd13 Fabp1 Nfkb1 Skp1 Psmb5 Fbxl17 Psmb4 Psmb7 Psmb6 Slc7a11 Psmb1 Nlrp3 Psmb3 Cox5a Psmb2 Rela Btrc Notch1 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Map1lc3b Psmd8 Psmd3 Psmd2 Alb Psmd1 Adrm1 Sem1 Cul1 P4hb Idh1 Ppara Rxra Prkaa2 mt-Co1 Myc Akt3 Txnrd1 Akt2 Akt1 Cox4i1 Cox4i2 Eif2ak3 Cat Stap2 Aqp8 Ero1a Prdx3 Csnk2a2 Mul1 Abcc3 Atf4 Sesn1 Dpp3 Mafg Gclc Gclm Prdx6 H13 Me1 Txnip Abcf2 Txnrd2 Gpx3 Txn2 Palb2 Gpx6 Gpx5 Gpx8 Blvrb Gpx7 Blvra Chd6 Gsta3 Ccl12 Trim21 Nudt2 Srxn1 Higd1c Nqo1 Brca1 Tkt Ubxn7 Sod3 Ccs Atox1 Cul3 mt-Co2 Cdkn2a mt-Co3 Ncor2 Stat3 Sqstm1 Txn Cox6a1 Cox6a2 Vcp Skp2 Hmox2 Ptk6 Cdkn1a Abcg2 Ncf1 Ncf2 Ncf4 Abcc1 Pgd Amer1 Csnk2b Gsk3b Cox6b1 Sesn2 Cox6b2 Coxfa4 Prkci Egf Bcl2 Pdgfa Bcl2l1 Areg Ncor1 Helz2 Cyba Carm1 Ep300 Tbl1x Cybb Hmox1 G6pdx Sin3a Hdac3 Prkcd Ncoa2 Ncoa1 Ufd1 Tbl1xr1 Gpx2 Smarcd3 Nploc4 Ncoa6 Hba-a1 Mafk Hbbt1 Med1 Bach1 Taldo1 Cox7a1 Cox7a2 Nfe2l2 Crebbp Atp7a Chd9 Keap1 Cox7a2l MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 96%9683686 Maturation of spike protein Ganab Canx Prkcsh Mgat1 Mogs PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 Fgf16 Frs2 Fgf18 Fgf2 Fgf1 Gab1 Fgf4 Fgf10 Fgf3 Fgf6 Fgf7 Fgf9 Fgf20 Ptpn11 Pik3ca Fgf23 Fgf22 Pik3r1 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 96%187706 Signalling to p38 via RIT and RIN Ngf Braf Rit1 Rit2 Ntrk1 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis Cdh2 Myog Myod1 Tcf3 Ntn3 Cdh4 Mapk11 Neo1 Ctnna2 Bnip2 Spag9 Cdh15 Myf6 Tcf4 Myf5 Abl1 Mef2d Cdon Ctnnb1 Tcf12 Mef2a Ctnna1 Mapk12 Mef2c Mapk14 Map2k6 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%199920 CREB phosphorylation Rps6ka5 Rps6ka3 Rps6ka1 Rps6ka2 Mapkapk2 DEVELOPMENTAL CELL LINEAGES%REACTOME%R-HSA-9734767.4 Developmental Cell Lineages Fgf2 Fgf4 Fgf10 Fgf7 Egf Fn1 Tgfa Lama5 Vtn Lamb2 Areg Lama1 Lamc3 Lamb3 Lama2 Lama3 Prl Lama4 Lamc1 Lamb1 Lamc2 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate Adhfe1 L2hgdh D2hgdh TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 Actl6a Actl6b Smarce1 Nfatc2 Ctsk Ctsl Prmt6 Prmt1 Psma4 Gp1ba Psma3 Psma6 Psma5 Psma2 Psma1 Pbrm1 Psmd12 Psmd11 Psmd14 Psmd13 Foxp3 Psmb5 Nr4a3 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Lifr Itch Prkcb Psma7 Tjp1 Psmc6 Lmo2 Psmc5 Lmo1 Psmc2 Psmc1 Psmc4 Kctd6 Psmc3 Ubc Arid2 Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Mnat1 Psmd1 Adrm1 Sem1 Prkcq Auts2 Trp73 Il2 Ccnh Cdk7 Esr1 Ifng H2ac20 Tcf3 Hdac1 Ldb1 Itga2b Mov10 H2ac12 H2ac11 Ago4 Spi1 Ago3 Ago2 Ago1 H2ac15 H3c7 H2ax Csnk2a2 Myl12a Ash2l Myb Hist1h2bp Cldn5 H2aj Lgals3 Yap1 Axin1 Ctla4 Gata3 Gata1 Gata2 H2bc9 Nfe2 Rspo3 H2bc7 H2bc8 H2bc3 H2ab2 Pcgf5 Ring1 H2bu2 Cbx8 Tnfrsf18 Phc2 Cbx6 Hipk2 Phc1 Src Cbx4 Cbx2 Tal1 Blk Arid1a Ccnd2 Phc3 Elf1 Rybp Arid1b Ccnd3 Elf2 Tcf12 Cbfb Ccnd1 Serpinb13 Cdk6 Pax5 Pf4 Kat2b Kmt2c Hist2h2aa1 Bmi1 Socs3 Socs4 Dpy30 Wdr5 Csnk2b Rnf2 Csf2 Kmt2d Kmt2b H2bc14 Ptpn11 Smarcb1 Setd1b H2bc21 Tnrc6c Setd1a H2bc26 Yaf2 Rbbp5 Abl1 Tnrc6a Smarca2 Tnrc6b Smarca4 Ep300 Smarcd1 Smarcd2 Sin3a Sin3b Il2ra Smarcc2 Smarcc1 Smarcd3 Crebbp Pml Zfpm1 Thbs1 Gpam CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%421270 Cell-cell junction organization Sp1 Arhgap32 Tyk2 Banp Birc2 Angptl4 Ang Xiap Kdm1a Zfp217 Ank3 Pomt1 Pomt2 Tgif2 Klf9 Strap Foxj2 Foxp2 Twist2 Twist1 Cdh4 Cdh15 Nectin1 Nectin2 Nectin3 Nectin4 Pard6b Il6 Cldn23 Cldn6 Cldn3 Cldn4 Cldn9 Canx Cldn20 Cldn22 Cldn7 Cldn8 Pard6g Cldn12 Rb1 Cldn15 Arid1a Cldn14 Cldn11 Cldn10 Cldn1 Dnm2 Cldn17 Kmt5a Mdm2 Zmym2 Cldn16 Cldn19 Cldn18 Cadm3 Cadm2 Cadm1 Cldn2 Mtbp Rack1 Foxq1 Il6st Wt1 Zc3h12a Farp2 Cdh9 Cdh7 Cdh6 Cdh5 Cdh3 Tle1 Sdk1 Pcsk7 Tiam1 Sdk2 Cdh19 Cdh17 Pkm Cdh13 Foxa2 Cdh12 Cdh10 Zbtb33 Hdac2 Mphosph8 Mcrip1 Prkci Smarca4 Il6ra Zeb2 Ctsb Ctss Hace1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rela Psma7 Psmc6 Pip5k1c Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Ganab Cdh2 Mogs Rnf19b H2ac20 Zeb1 Tcf3 Hdac1 Myc Prkcsh Traf7 Rpn2 Rpn1 Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 Sox10 H3c7 Ezh2 H2ax Snai2 Csnk2a2 Suz12 Rac1 Hist1h2bp Jak1 Cldn5 H2aj Jup Jak2 Vav2 H2bc9 H2bc7 H2bc8 H2bc3 Vcl Stat3 Tmem258 Arhgef4 H2ab2 Mycn Sec11c Sec11a H2bu2 Stt3a Src Ctnnb1 Eps15 Cbll1 Ostc Tcf12 Ctnnd1 Cdh1 Crb3 Patj Pals1 Mapk1 Mapk3 Hist2h2aa1 Furin Ctbp1 Ctbp2 Pcsk6 Dad1 Ddost Csnk2b Eed H2bc14 Pard6a Pard3 F11r Tfap2a H2bc21 Tnrc6c H2bc26 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Spcs3 Spcs1 Hoxc8 Spcs2 Heyl Cdh8 Adam19 Adam33 Cdh24 Elmo1 Ctnna1 Snai1 Klf4 Prdm8 Ilf3 Foxf1 Bhlhe22 Cdh11 Sirt1 Dock1 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex Tlr4 Tab3 Ticam2 Tab2 Map3k7 Ticam1 Tab1 Cd14 Ly96 Traf6 Irak2 Ubc INTERFERON SIGNALING%REACTOME%R-HSA-913531.6 Interferon Signaling Tyk2 Eif4g2 Eif4g3 Pim1 Eif4e3 Ifnar1 Ifngr2 Ifngr1 Fancc Fnta Fntb Fkbp5 Stat2 Actb Irf2 Sphk1 Casp1 Fcgr1 Trp53 Ybx1 Ptpn2 Ifng Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nck1 Ncam1 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Kpna1 Aaas Nup214 Nup210 Nup155 Nup153 Ptafr Camk2g Camk2d Camk2b Camk2a Eif2ak2 Sfn Kpnb1 Kpna4 Kpna7 Kpna3 Abce1 Isg15 Dnajc3 Cd44 Hspa1a Irf5 Hspa8 Hspa5 Ifnb1 Nup37 Nup160 Map2k6 Ppp2cb Ppp2ca Nup43 Ranbp2 Plcg1 Pin1 Irf4 Ifi35 Ifi30 Gbp5 Eif4a2 Gbp7 Nup107 Eif4a1 Pde12 Ifi27 Trim17 Trim14 Trim10 Icam1 Atf6 Ifit2 Snca Oas1g Egr1 Ppp2r1b Ppp2r1a Fancl Fancm Fanca Fancb Rnasel Fance Fancf Prkcd Eif4a3 Fancg Nedd4 Pggt1b Hspa1l Rsad2 Trim6 Trim8 Nup85 Trim3 Trim2 Ifit1bl2 Ifitm2 Trim12c Ifitm3 Ube2l6 Faap24 Usp18 Prkra Faap20 Ip6k2 Tarbp2 Ilf2 Mid1 Flnb Oasl1 Trim68 Isg20 Ppp2r5a Faap100 Sec13 Vcam1 Hspa2 Trim46 Trim45 Adar Trim62 Ciita Oas3 Irf8 Samhd1 Irf6 Irf9 Cenps Trim26 Ifit3b Trim38 Irf7 Trim35 Dhx9 Trim31 Ikbkb Ifi44l Nup133 Eif2s3x Ikbkg Eif2s2 Eif2s1 Socs1 B2m Npm1 H2-Q10 Ubc Becn1 Psmb8 Cenpx Ube2n Chuk Uba7 H2-Eb1 Smad7 Ube2i Pias1 Ppm1b Eif2ak3 Mt2 Jak1 Jak2 Trim21 Raf1 Stat3 Stat1 Arih1 Cdk1 Actg1 Ube2e1 Ifih1 Trim25 Mavs Rigi Oas2 Gbp2 Gbp3 Gbp9 Mapk1 Mapk3 Furin Socs3 Eif4g1 Irf1 Ptpn6 Ptpn11 H2-M5 H2-M3 Eif4e Irf3 H2-Q1 Bst2 Dus2 Ptpn1 Ilf3 Flna Pml MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 96%2555396 Mitotic Metaphase and Anaphase Tuba1b Tuba1a Fbxo5 Ankle2 Tuba1c Tubal3 Chmp2a Tubb2b Chmp3 Tubb2a Chmp7 Chmp6 Lmnb1 Tuba4a Chmp4c Chmp4b Ppp2r2a Tuba8 Tuba3b Tubb6 Tubb3 Tubb1 Tubb4b Tubb4a Nup93 Nup35 Nup54 Pom121 Nup205 Nup188 Ndc1 Nup62 Banf1 Nup155 Kpnb1 Ran Clasp1 Clasp2 Pafah1b1 Smc3 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Rad21 Kif2b Kif2c Dync1li2 Pmf1 Wapl Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Stag2 Stag1 Ppp2r1b Ppp2r1a Pds5b Pds5a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Nuf2 Ccnb2 Nup85 Cdca8 Incenp Cdca5 Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Psma4 Cenpo Cenpn Spast Psma3 Cenpm Espl1 Psma6 Mis12 Psma5 Lemd2 Nup133 Psma2 Cenpl Cc2d1b Psma1 Ist1 Zwilch Cenpk Vrk1 Cenpi Sirt2 Cenph Psmd12 Psmd11 Smc1a Cenpf Psmd14 Cenpe Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Ube2i Pttg1 Rcc1 Vps4a Tnpo1 Plk1 Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdk1 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Emd Lemd3 Lbr Xpo1 TBC RABGAPS%REACTOME DATABASE ID RELEASE 96%8854214 TBC RABGAPs Rab8a Rab6b Rab6a Tsc2 Tsc1 Rab11a Rabgef1 Gga2 Gga1 Rab4a Gga3 Optn Rabgap1 Rab7 Tbc1d14 Tbc1d13 Tbc1d16 Tbc1d15 Rab11b Arf6 Rab33b Rab33a Tbc1d17 Rabep1 Tbc1d2 Rab35 Tbc1d7 Gabarapl2 Rab5a Tbc1d10c Rab8b Rab5c Tbc1d10b Rab5b Tbc1d10a Ulk1 Sytl1 Tbc1d25 Gabarap Tbc1d20 Tbc1d24 Map1lc3b ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 96%1482788 Acyl chain remodelling of PC Pla2g2e Pla2g2d Pla2g4a Pla2g2f Pla2g4d Lpcat4 Pla2g12a Pla2g5 Pla2g1b Pla2r1 Pla2g4f Pla2g4c Pla2g4e Lpcat3 Pla2g10 Lpcat2 Plbd1 Lpcat1 Plb1 Tmem86b Pnpla8 Plaat3 Pla2g3 Pla2g6 Mboat2 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME%R-HSA-9022534.2 Loss of MECP2 binding ability to 5hmC-DNA MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 96%9636667 Manipulation of host energy metabolism Pgk1 EG433182 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 96%9627069 Regulation of the apoptosome activity Diablo Mapk1 Apaf1 Mapk3 Apip Xiap Aven Uaca Casp9 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling Fas Fasl Casp8 Fadd RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation Snapc5 Snapc3 Snapc4 Snapc1 Snapc2 Znf143 Brf2 Polr3gl Gtf3a Crcp Polr3a Polr3d Brf1 Polr3e Polr1c Polr3b Polr3c Polr3h Polr3f Pou2f1 Polr1d Polr3g Polr3k Gtf3c2 Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 Gtf3c5 Bdp1 Tbp Polr2h Polr2e Polr2f Polr2k IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 96%2428924 IGF1R signaling cascade Fgf16 Frs2 Fgf15 Them4 Irs1 Fgf18 Irs2 Fgf2 Pik3c3 Fgf1 Nras Irs4 Fgf4 Gab1 Fgf10 Igf2 Fgf3 Igf1 Fgf6 Sos1 Fgf7 Fgf9 Hras Trib3 Fgf20 Ptpn11 Gab2 Fgf23 Fgfr4 Fgf22 Akt2 Pde3b Tlr9 Pik3r4 Flt3l Pik3cb Igf1r Pik3ca Flt3 Pdpk1 Pik3r1 Pik3r2 Klb ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 96%9819196 Zygotic genome activation (ZGA) Trp53 Crebbp Tut7 Tut4 Yap1 Ep300 Tead4 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390650 Histamine receptors Hrh4 Hrh2 Hrh3 Hrh1 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME DATABASE ID RELEASE 96%2033515 t(4;14) translocations of FGFR3 Fgfr3 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.4 Hh mutants are degraded by ERAD Sel1l Psma4 Psma3 Syvn1 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Derl2 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Vcp Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Shh Ubc Psmd7 Psmd6 Psmd8 Erlec1 Psmd3 Psmd2 Psmd1 Os9 Adrm1 Sem1 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 96%429947 Deadenylation of mRNA Cnot9 Cnot6l Cnot8 Cnot11 Pabpc1 Tut7 Tut4 Paip1 Eif4b Pan2 Eif4e Pan3 Eif4a2 Eif4a1 Cnot10 Tnks1bp1 Eif4a3 Cnot3 Parn Cnot2 Cnot1 Cnot7 Cnot6 Eif4g1 Cnot4 SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000471 Scavenging by Class B Receptors Prdx1 Cd36 S100a9 Ssc5d Saa3 Cd5l Apoa1 Apob MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-HSA-453279.6 Mitotic G1 phase and G1 S transition Fbxo5 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Cdc25a Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Ppp2r2a Psmd8 Psmd3 Psmd2 Mnat1 Psmd1 Adrm1 Sem1 Cul1 Top2a Ccnh Cdk7 Mybl2 Hdac1 Myc Rbl2 Akt3 Akt2 Akt1 Tyms Dhfr Tk1 Rbl1 Dyrk1a Lyn Pcna Orc5 Orc4 Orc6 Orc1 Mcm8 Orc3 Orc2 Pole3 Pole2 Pole4 Rrm2 Rpa1 Jak2 Rpa2 Rpa3 Cdc7 Pole Cdkn2a Cdkn2b Cdkn2c Cdk1 Ccne1 Ccne2 Tfdp2 Tfdp1 Skp2 Rb1 Ccnd2 Ccnd3 Ccnd1 Mcm7 Cdk6 Cdk4 Cdk2 Mcm3 Ptk6 Mcm4 E2f1 Ccna1 Cks1b Mcm5 E2f2 Ccna2 Cables1 Mcm6 E2f3 Max Lin54 Cdc45 Cdkn1a Mcm2 Cdkn1b Cdt1 Lin9 Cdkn1c Gmnn Wee1 Lin37 Dbf4 Mcm10 Ppp2cb Ppp2ca Cdc6 Rbbp4 Abl1 Ppp2r1b Ppp2r1a Prim2 Prim1 Pola2 Pola1 E2f4 E2f5 E2f6 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux Apoe Nr1h2 Rxra Ncor2 Tnrc6c Ncor1 Eepd1 Nr1h3 Kdm1a Tnrc6a Arl4c Tnrc6b Kdm1b Kdm3a Apod Ep300 Abcg1 Tbl1x Mov10 Ago4 Ago3 Hdac3 Ago2 Ago1 Kdm4a Gps2 Ncoa1 Tbl1xr1 Apoc1 Apoc2 Abca1 Abcg8 Rxrb Abcg5 Apoc4 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%500792 GPCR ligand binding Adora2b C3ar1 App S1pr1 Ucn Sct Ihh Adm Adcyap1 Ramp1 Shh Wnt5a Wnt9a Iapp Wnt9b Ucn3 Fzd10 Wnt10a Crhr1 Wnt10b Crhbp Gipr Gip Calcrl Smo Glp1r Crh Pth1r Wnt8b Wnt8a Cysltr2 Wnt16 Cysltr1 Wnt11 Calcr Ghrhr Adgre5 Gng10 Pth Dhh Adgre1 Gcgr Pth2 Glp2r Wnt6 Vipr2 Calca Vipr1 Gng3 Gng2 Ptch2 Ptch1 Gng4 Wnt7b Gng7 Ghrh Wnt3a Gng8 Pth2r Wnt7a Wnt2 Pthlh Wnt1 Wnt4 Wnt3 Fzd1 Gngt1 Gngt2 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Gcg Adcyap1r1 Wnt2b Ramp3 Ramp2 Gnb2 Adm2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Vip Gng12 Gng13 Ccl12 Gabbr1 Gabbr2 Rho Saa3 C3 C5 Avpr2 Sstr3 Oxtr Avpr1b Avpr1a Oxt Avp Mchr1 Adora2a Pdyn Galr2 Galr3 Galr1 Fpr1 Tas1r2 Tas1r1 Tas1r3 Pnoc Tas2r131 Tas2r135 Tas2r137 Tas2r136 Gpr18 Tas2r140 Gpbar1 Tas2r4 Fpr-s1 Ptger4 Ccr5 Tas2r7 Ptger2 Ptger3 Mtnr1a Mtnr1b Agtr2 Gpha2 Gpr37 Gpr35 Gpr31 Rgr Ccl17 Ccl11 Ptgdr2 Cx3cl1 Ccl28 Ccl25 P2ry13 Ccl22 P2ry12 Ccl20 Gpr55 P2ry14 Lhcgr Oxgr1 Sucnr1 Prlhr Ece1 Psap Ccl7 P2ry4 Ccl5 Ccl4 Ccl3 Ccl2 Ccl1 Mrgprd Rrh Ptgdr Apln Tas2r39 Oprd1 Tas2r38 Cmklr1 Sstr5 Sstr4 Kel Sstr2 Sstr1 Gpr183 Lhb Ppbp Ccr10 Nln Tas2r16 Cx3cr1 Tas2r13 Ppy Ccr1 Npbwr1 Fshb Mc2r Fshr Pf4 Ccr9 Ccr8 Ccr7 Ccr6 Ccr4 Ccr3 Ccr2 Plppr1 Gal Plppr4 Plppr5 Plppr2 Plppr3 Penk Npb Opn1mw Npw Mas1 Tas2r40 Tas2r41 Hcar1 Hcar2 Cxcr1 Cxcr2 Npy1r Cxcr3 Xk Cxcr5 Cxcr6 Oprl1 Prlh Cxcl11 Hebp1 Cxcl10 Opn1sw Aplnr Opn3 Ccrl2 Gper1 Opn5 Pyy Adora1 Adora3 Cxcl16 Cxcl13 Tas2r119 Npy5r Grm3 Grm2 Grm4 Grm7 Grm8 Npy4r Ptgir Tas2r120 Tshr Cxcl9 S1pr3 Cxcl1 S1pr2 S1pr5 Cxcl2 S1pr4 Cxcl3 Cxcl5 Tas2r107 Gpr37l1 Npy2r Ackr3 Ackr4 Cnr1 Ackr1 Ackr2 Cnr2 Cort Anxa1 Npy Cxcr4 Cxcl12 Ednra Npff Trhr Gnrh1 Nmbr Fpr2 Ptgfr Agtr1a Nmb Lpar6 Xcr1 Lpar5 Ppan Grpr Gpr17 Nms Nmu Cckar Nmur2 Gnrhr Nmur1 Ntsr2 Ntsr1 Brs3 Ptger1 Gpr132 Edn2 Cckbr F2 Hcrt Grp Kiss1r Nps Ptafr Npffr1 Npffr2 Gprc6a Prok2 Gpr4 Qrfp Prok1 Npsr1 Agt P2ry10 F2rl1 F2rl2 F2rl3 Prokr2 Ghsr Prokr1 Gpr65 Gpr68 Uts2 Tacr1 Tacr3 Tacr2 Casr F2r Ffar3 Ffar4 Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng2 Tac3 Tac1 Opn4 Pmch Ltb4r1 Ltb4r2 Trh Grm1 Grm5 Lpar4 Lpar3 Lpar2 Lpar1 Qrfpr Xcl1 Kiss1 P2ry6 P2ry2 P2ry1 Hcrtr2 Hcrtr1 Uts2b Cck Uts2r Adra2a Adra2c Adra2b Sst C5ar2 C5ar1 Oprm1 Ednrb Edn1 Edn3 Mc1r Mc5r Rxfp3 Rln3 Rxfp2 Rxfp1 Mc4r Rln1 Pomc Insl3 Rxfp4 Insl5 Mc3r Oprk1 Cga Tshb Adra1b Adra1a Adra1d Tbxa2r Gpr143 Htr4 Chrm1 Hrh1 Chrm3 Htr6 Chrm2 Htr7 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Htr2a Htr2c Htr2b Drd1 Adrb2 Drd2 Adrb1 Drd3 Drd4 Drd5 Adrb3 Taar8b Htr1d Taar6 Htr1f Taar9 Taar2 Taar5 Htr1b Htr1a Taar1 Htr5a NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%205043 NRIF signals cell death from the nucleus Psen2 Ncstn Ngf Aph1b Itgb3bp Ngfr Sqstm1 Mapk8 Traf6 Ubc Psen1 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764274 Regulation of Expression and Function of Type I Classical Cadherins Sp1 Arhgap32 Psma4 Psma3 Psma6 Banp Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Kdm1a Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Zfp217 Psma7 Psmc6 Pip5k1c Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Ank3 Psmd3 Psmd2 Pomt1 Psmd1 Adrm1 Sem1 Pomt2 Ganab Mogs Tgif2 H2ac20 Tcf3 Zeb1 Klf9 Hdac1 Strap Foxj2 Foxp2 Myc Prkcsh Rpn2 Rpn1 Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 Twist2 Ezh2 H2ax Twist1 Snai2 Csnk2a2 Suz12 Hist1h2bp H2aj Jup H2bc9 H2bc7 H2bc8 H2bc3 Vcl Tmem258 H2ab2 Mycn Sec11c Sec11a H2bu2 Stt3a Src Canx Ctnnb1 Eps15 Cbll1 Ostc Rb1 Arid1a Tcf12 Ctnnd1 Cdh1 Dnm2 Kmt5a Mdm2 Zmym2 Mapk1 Mapk3 Hist2h2aa1 Furin Ctbp1 Mtbp Pcsk6 Ctbp2 Dad1 Rack1 Foxq1 Wt1 Ddost Csnk2b Eed Tle1 Pcsk7 Pkm H2bc14 Foxa2 Zbtb33 Hdac2 Mphosph8 Tfap2a Mcrip1 H2bc21 Tnrc6c H2bc26 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Smarca4 Zeb2 Ctsb Ctss Spcs3 Spcs1 Spcs2 Ctnna1 Snai1 Klf4 Sirt1 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-HSA-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane Cd274 Stt3a Stt3b Magt1 Ostc B3gnt3 Pdcd1 Mib2 Tusc3 Tmem258 Jak1 Dad1 Rpn2 Rpn1 Pdcd1lg2 Ddost G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation Pomc Gngt1 Gngt2 Gna11 Gng10 Gna15 Gna14 Gng3 Gng2 Gnb2 Gnaq Gnb1 Gng4 Gnb4 Gnb3 Gng7 Gnb5 Gng11 Gng8 Gng12 Gng13 Pdyn Oprm1 HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.7 Hyaluronan degradation Gusb Hmmr Cemip Hyal5 Lyve1 Hyal2 Hexa Hexb Stab2 Chp1 Hyal4 Hyal3 Cd44 Hyal1 Slc17a5 Slc9a1 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702632 sunitinib-resistant FLT3 mutants Flt3 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022928 HS-GAG biosynthesis Glce Hs2st1 Ndst1 Gpc1 Ndst2 Ndst3 Gpc3 Ndst4 Gpc2 Hspg2 Slc35d2 Gpc5 Sdc4 Sdc3 Gpc4 Sdc2 Hs3st3b1 Gpc6 Hs6st3 Hs6st2 Hs6st1 Hs3st3a1 Ext2 Ext1 Extl2 Sdc1 Hs3st4 Hs3st1 Extl3 Hs3st2 Hs3st5 Hs3st6 Agrn DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 Nus1 Dhdds KILLING MECHANISMS%REACTOME%R-HSA-9664420.3 Killing mechanisms Wnt5a Nox1 Rac1 Noxo1 Mapk8 Dvl1 Cyba Fzd7 Dvl2 Dvl3 Jun Noxa1 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%5654688 SHC-mediated cascade:FGFR1 Fgf2 Fgf1 Nras Fgf4 Fgf10 Fgf3 Fgf6 Sos1 Fgf9 Hras Fgf20 Fgf23 Fgf22 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation Tlr4 Tapbp Sec61b Fgb Fga Itgb5 Ctsl Fgg Psma4 Ikbkb Psma3 Psma6 Psma5 Psma2 S100a9 Psma1 S100a8 Ikbkg Psmd12 Psmd11 Calr Tlr1 Cd14 Psmd14 Btk Tlr6 Psmd13 Tlr2 Sec22b Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 B2m H2-Q10 Vamp8 Psma7 Psmc6 Mrc1 Psmc5 Psmc2 Psme2 Psmc1 Psme1 Psmc4 Psmc3 Ubc Psmb10 Fcgr1 Psmd7 Itgav Psmd6 Psmd8 Psmd3 Psmb9 Psmd2 Ncf1 Psmb8 Psmd1 Ncf2 Ncf4 Adrm1 Sem1 Chuk S100a1 H2-M5 Cd36 H2-M3 Tirap Myd88 Snap23 Cyba Cybb H2-Q1 Vamp3 Ctss Pdia3 Lnpep Mrc2 Ly96 Sec61a2 Sec61a1 Tap2 Tap1 Cd207 Stx4 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME%R-HSA-5619035.3 Defective SLC17A5 causes Salla disease (SD) and ISSD Slc17a5 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound Cacnb2 Cacna1d Capzb Lrrc52 Capza1 Capza2 Bsn Syp Rab3a Dnajc5 Otof Cabp2 Slc17a8 Pclo Cask Twf1 Myo3a Myo3b Fscn2 Xirp2 Grxcr2 Eps8 Grxcr1 Chrna9 Kcnq4 Myo7a Pls1 Pcdh15 Tmc1 Espnl Ush1g Tmc2 Cib2 Lhfpl5 Otog Slc26a5 Myo1c Whrn Twf2 Clic5 Sptan1 Epb41l3 Tmie Strc Cdh23 Ush1c Ezr Otogl Mpp1 Gsn Pjvk Eps8l2 Espn Myo15a Tprn Ripor2 Rdx Msn Kcnmb1 Kcnma1 Kcnn2 Sptbn1 Chrna10 Snap25 Vamp2 Stx1a Myh9 Syn1 Cacna2d2 Atp2b1 SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 Sp1 Arrb1 Fgf2 Tgfb1 Smad3 Smad4 Myog Myod1 Tcf3 Gipc1 Hells Rxra Tgfb2 Inha Rara Tgfbr3 Mmp14 Tnrc6c Mmp16 Timp1 Myf6 Timp2 Tcf4 Acvr2a Myf5 Klf16 Tnrc6a Inhba Tnrc6b Mycn Ep300 Mov10 Ago4 Ago3 Ago2 Ago1 Tcf12 Psen1 Psen2 Ncstn Aph1b Tgfbr1 Tgfbr2 Arrb2 PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964208 Phenylalanine metabolism Qdpr Pah Asrgl1 Pcbd1 Kyat1 Il4i1 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 96%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) Slc2a1 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs Ppp1cc Fkbp1a Smad2 Itgb5 Tgfb1 Smad3 Smad4 Itgb3 Strap Nedd8 Smad7 Tgfb2 Tgfbr3 Ppp1ca Ppp1cb Smurf2 Smurf1 Ube2m Itga8 Pmepa1 Tgfb3 Ltbp3 Ltbp2 Ltbp4 Ltbp1 Uchl5 Itgb8 Itgb6 Cbl Usp15 Xpo1 Bambi Mtmr4 Stub1 Ubc Itgav Itgb1 Nedd4l Furin Tgfbr1 Tgfbr2 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling Erbb2 Akt3 Akt2 Akt1 Nrg1 Rnf41 Usp8 Nrg2 Ubc CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963888 Chylomicron assembly Apoc2 Apoe Apoa2 Sar1b Apoa4 Mttp Apoc3 Apoa1 P4hb Apob DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 Galm NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression Sap30l Suds3 Sap30 H2bc9 Sap18b H2bc7 H2bc8 Arid4b H2bc3 H2ab2 Polr1c Polr1d H2bu2 Ttf1 Polr1b Polr1a Polr1g Polr1e Polr1h Sap30bp Taf1d Polr2h Hist2h2aa1 Taf1a Polr2e Taf1c Polr2f Taf1b Polr2k Mnat1 Sap130 Baz2a Ubtf Gtf2h2 Gtf2h1 Gtf2h4 Gtf2h3 Gtf2h5 Ercc2 Ccnh Ercc3 Mbd2 Cdk7 H2bc14 H2ac20 Hdac2 Hdac1 H2bc21 H2bc26 H2ac12 H2ac11 Sin3a Sin3b H2ac15 Tbp Smarca5 Dnmt3b H3c7 Dnmt1 H2ax Hist1h2bp H2aj ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 96%2214320 Anchoring fibril formation Lamb3 Lama3 Bmp1 Col7a1 Tll2 Lamc2 Tll1 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717329 lorlatinib-resistant ALK mutants Alk DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME DATABASE ID RELEASE 96%9845621 Defective VWF cleavage by ADAMTS13 variant Adamts13 Vwf MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a St3gal2 St3gal1 St6gal1 St6galnac3 St6galnac4 St6galnac2 St3gal4 Galnt1 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes Trp53 Cdkn1a Pcbp4 Zfp385a CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress Rpa2 Rpa3 Atm Nup133 Ywhae Hspa1a Fkbp4 Hsp90ab1 Vcp Hspa8 Hspa5 Mapk1 Mapk3 Rptor Nup37 Mapkapk2 Dnajc7 Nup160 Hsph1 Dnajc2 Cryab Hikeshi Hspa14 Nup43 Gsk3b Hspa13 Akt1s1 Rps19bp1 Hsbp1 Mlst8 Ranbp2 St13 Hspa12b Hspa12a Bag5 Nup93 Bag4 Hspa9 Nup50 Hsf1 Nup35 Mtor Bag3 Nup54 Bag1 Pom121 Hspb8 Nup205 Dnajb6 Nup188 Dnajb1 Tpr Hspa4l Nup107 Rae1 Hspa4 Hdac6 Ndc1 Ccar2 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Ep300 Nup153 Hspa1l Nup85 Camk2g Camk2d Camk2b Camk2a Crebbp Hsp90aa1 Sec13 Bag2 Hspa2 Sirt1 Rpa1 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER Gtf2h3 Rpa2 Gtf2h5 Ercc2 Ccnh Cetn2 Sumo3 Ercc3 Cdk7 Rpa3 Pias3 Rnf111 Usp45 Parp2 Ube2i Ddb1 Parp1 Pias1 Xpa Cul4a Xpc Rad23a Cul4b Rad23b Ercc1 Ercc4 Ercc5 Chd1l Rbx1 Ubc Mnat1 Gtf2h2 Gtf2h1 Ube2v2 Ube2n Gtf2h4 Ddb2 Rpa1 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death Tlr4 Ticam2 Ticam1 Ripk3 Cd14 Ly96 Casp8 Ripk1 Fadd PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163358.7 PKA-mediated phosphorylation of key metabolic factors Prkaca Mlxipl Pfkfb1 Prkacb DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) Slc6a3 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 96%1169408 ISG15 antiviral mechanism Kpna4 Kpna7 Eif4g2 Eif4g3 Kpna3 Eif4e3 Nup133 Isg15 Stat1 Arih1 Ube2e1 Trim25 Rigi Ubc Mapk3 Becn1 Nup37 Ube2n Eif4g1 Nup160 Uba7 Nup43 Ranbp2 Plcg1 Pin1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Eif4e Nup188 Tpr Eif4a2 Nup107 Rae1 Eif4a1 Ndc1 Irf3 Nup42 Ppm1b Nup62 Nup88 Kpna1 Aaas Nup214 Nup210 Nup155 Nup153 Eif4a3 Nedd4 Nup85 Ifit1bl2 Ube2l6 Usp18 Eif2ak2 Jak1 Flnb Kpnb1 Sec13 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 96%171007 p38MAPK events Ralgds Nras Mapk12 Mapkapk3 Mapk13 Mapkapk2 Mapk14 Hras Rala Mapk11 Ralb TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) Vamp2 DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system F2 F12 Klkb1 Serping1 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 96%156590 Glutathione conjugation Mgst3 Gsta3 Mgst2 Mgst1 Gstk1 Gstm2 Ggt1 Gstz1 Gsta5 Chac1 Chac2 Gstm7 Gstm5 Gstm4 Gstm1 Ggt5 Gsto2 Esd Cndp2 Hpgds Gstt2 Gstt1 Oplah Akr1a1 Gclc Gclm Gss Gsto1 Ggt7 Ggt6 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 96%9956529 ASL variants cause argininosuccinate aciduria Asl RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73864 RNA Polymerase I Transcription H2bc9 H2bc7 H2bc8 H2bc3 Gatad2a Gatad2b Ehmt2 H2ab2 Polr1c Mbd3 Polr1d H2bu2 Mta1 Mta3 Ttf1 Polr1b Polr1a Polr1g Kat2b Polr1e Polr1h Kat2a Taf1d Polr2h Hist2h2aa1 Mapk3 Taf1a Polr2e Taf1c Polr2f Taf1b Polr2k Mnat1 Cbx3 Ubtf Gtf2h2 Gtf2h1 Gtf2h4 Gtf2h3 Gtf2h5 Ercc2 Ccnh Ercc3 Mbd2 Cdk7 H2bc14 H2ac20 Hdac2 Hdac1 H2bc21 H2bc26 Rbbp4 Rbbp7 Chd3 Chd4 H2ac12 H2ac11 Rrn3 Ercc6 H2ac15 Tbp H3c7 H2ax Cavin1 Mta2 Hist1h2bp H2aj CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly Ercc2 Rtel1 Ndor1 Mms19 Brip1 Nubp2 Ciao1 Nubp1 Ciao2b Pold1 Ciao3 Ciapin1 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions Fgfr1 Erlin2 Bag4 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation Fgf16 Fgf23 Fgf18 Fgf2 Fgf1 Fgf4 Fgf9 Fgfr3 Fgf20 GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation Gnat3 Gng10 Kcnj3 Kcnj2 Gnal Gng3 Gng2 Gng4 Gng7 Gng8 Gabbr1 Gabbr2 Gngt1 Gngt2 Adcy3 Adcy4 Adcy1 Adcy2 Kcnj9 Adcy7 Kcnj6 Adcy8 Kcnj5 Adcy5 Kcnj4 Adcy6 Adcy9 Gnb2 Gnb1 Kcnj10 Gnb4 Gnai2 Gnb3 Gnai1 Gnb5 Gng11 Gnai3 Kcnj12 Gng12 Gng13 Kcnj15 Kcnj16 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%8868773 rRNA processing in the nucleus and cytosol Xrn2 Nop2 Nop58 Nop56 Rps14 Rpl4 Rps16 Las1l Rps18 Rrp1 Csnk1d Exosc9 Rps19 Ltv1 Exosc8 Mtrex Exosc5 Rpsa Rrp9 Dis3 Rpl37 Rpp38 Exosc4 Rpl39 Pwp2 Exosc7 Rps10 Bysl Exosc6 Fbl Rps11 Rpp30 Exosc1 Rpl7 Ftsj3 Exosc3 Imp3 Exosc2 Rpp21 Rpl32 Imp4 Rps9 Rpp25 Rps7 Dkc1 Rps5 Nhp2 Rpl24 Wdr75 Rpl26 Senp3 Rpl22 Isg20l2 Rpl23 Dimt1 Exosc10 Emg1 Eri1 Dhx37 Rps25 Gar1 Rps26 Pno1 Pdcd11 Utp20 Rps21 Nop14 Pelp1 Utp25 Rpl39l Rcl1 Nop10 Rps15a Tbl3 Nol12 Nol11 Rpp40 Wdr3 Bud23 Rps27l Dcaf13 Rplp2 Utp15 Rpl22l1 Rbm28 Rplp1 Riok3 Rpl13a Heatr1 Rpl18a Utp11 Nob1 Rpl17 Nat10 Rpl18 Ddx52 Rpl19 Utp18 Rpl10l Wdr43 Rpl11 Wdr46 Noc4l Rps3 Riok1 Rps4x Riok2 Gnl3 Ddx49 Ddx47 Thumpd1 Nip7 Tsr3 Rrp36 Nol9 Mphosph6 Rpp14 Nol6 Utp14a Mphosph10 Trmt112 Pes1 Bms1 C1d Krr1 Utp3 Utp4 Utp6 Bop1 Ebna1bp2 Wdr18 Tsr1 Ddx21 Wdr12 Csnk1e Rps27 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 96%114604 GPVI-mediated activation cascade Gp6 Mpig6b Fcer1g Lck Pdpn Vav2 Ptpn6 Rhoa Ptpn11 Prkcz Plcg2 Rac2 Fyn Rhog Lyn Clec1b Rhob Pik3cg Pik3cb Pik3ca Lcp2 Rac1 Lat Syk Vav1 Pik3r5 Pdpk1 Pik3r6 Pik3r1 Pik3r2 Vav3 INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 96%6783783 Interleukin-10 signaling Ccl12 Ccl22 Il12b Ccl20 Csf2 Il10rb Il12a Il10ra Tnf Tnfrsf1b Tyk2 Tnfrsf1a Lif Fcer2a Il18 Il1r2 Il1rn Cxcl10 Ccl5 Csf3 Ccl4 Ccl3 Stat3 Timp1 Icam1 Il1r1 Csf1 Il6 Cd86 Fpr1 Cd80 Ptafr Il10 Cxcl1 Ccr1 Cxcl3 Ccr5 Il1a Il1b Ptgs2 Jak1 Ccr2 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%1222499 Latent infection - Other responses of Mtb to phagocytosis Ltf GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 96%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Gsk3b Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Nfe2l2 Adrm1 Sem1 Cul1 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 96%76002 Platelet activation, signaling and aggregation Ppia Rasgrp1 App Plcg2 Tgfb2 Timp1 Mgll Vegfa Tgfb3 Tuba4a Gna11 Gna15 Gna14 Ptk2 Syk Gnaq Gnai2 Alb Gnai1 Gnai3 Pfn1 A2m Gnat3 Apool Gng10 Cap1 Cd36 Itga2b Gng3 Gng2 Gng4 Gng7 Gng8 F2 Gngt1 Gngt2 F2rl2 F2rl3 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 Cd9 F2r Itpr3 Itpr2 Tgfb1 Itpr1 Kng2 Prkcg Aldoa P2ry1 Lcp2 Serpine1 Hspa5 Lat Pros1 Gas6 Adra2a Adra2c Adra2b Gp6 Mpig6b Fcer1g Pdpn Egf Cd109 Nhlrc2 Phactr2 Stxbp2 Stxbp3 Tex264 Fermt3 Vti1b Lefty2 Chid1 Manf A1bg Pdgfb Islr Sparc Pcyox1l Apoh Hrg Pla2g4a Gtpbp2 Ecm1 Ola1 Prkcd Orm3 Ctsw Calu Serping1 Rab27b Selenop Lhfpl2 Actn4 Sytl4 Clu Ahsg Spp2 Vegfd Vegfc Vegfb Serpina3n Cd63 Timp3 Rapgef4 Rapgef3 Tor4a Cfd Mpl Fam3c Trpc6 Serpinf2 Thbs1 Cfl1 Trpc7 F13a1 Tmx3 Anxa5 Scg3 Trpc3 Qsox1 Selp Lgals3bp Cyrib Sccpdh Srgn Wdr1 Maged2 Pecam1 Endod1 Thpo Aplp2 Gp1ba Clec3b Mmrn1 Habp4 Fn1 Plg Bcar1 Ttn Rarres2 Cdc37l1 Plek Tagln2 Itih4 Itih3 Aamp Prkcb F5 F8 Serpina1d Prkcq Rasgrp2 Prkca Igf2 Igf1 Daglb Dgka Dgkb Abhd6 Akt1 Dgke Abhd12 Dgkg Dgkh Dgki Dgkk Dgkq Prkch Dgkz Dagla Prkce Lyn Ywhaz Actn2 Lamp2 Rhob Rac1 Vav1 Pik3r5 Pik3r6 Pik3r1 Pik3r2 Pcdh7 Apbb1ip Vav3 Arrb2 Arrb1 Fgb Fga Rap1b P2ry12 Vav2 Vwf Abcc4 Fgg Itgb3 Raf1 Psap Tln1 Rac2 Vcl Gna12 Tbxa2r Gna13 Actn1 Src Ppbp Pik3cg Pik3cb Pf4 Hgf Cyb5r1 Pik3ca Tf Shc1 Mapk1 Mapk3 Rap1a Pdpk1 Mapk14 Lck Ptpn6 Sos1 Crk Rhoa Prkcz Ptpn11 Fyn Csk Brpf3 Rhog Clec1b Ptpn1 Gp9 Gp1bb Flna Gp5 Apoa1 Stx4 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1971475 Glycosaminoglycan-protein linkage region biosynthesis Uxs1 Fam20b Xylt1 Xylt2 Pxylp1 Gpc1 Ncan Bgn Gpc3 Cspg5 Gpc2 Cspg4 Dcn Hspg2 Bcan Gpc5 Sdc4 Vcan Sdc3 Gpc4 Sdc2 Gpc6 B4galt7 Sdc1 Agrn B3gat3 B3galt6 B3gat1 B3gat2 UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases Actl6a Tgfb1 Psma4 Nfrkb Psma3 Psma6 Psma5 Ino80e Psma2 Tfpt Psma1 Ino80d Ino80c Ino80b Psmd12 Actr5 Psmd11 Actr8 Psmd14 Ruvbl1 Psmd13 Foxk2 Foxk1 Uchl3 Psmb5 Psmb4 Actb Hcfc1 Yy1 Psmb7 Senp8 Psmb6 Asxl1 Psmb1 Uchl1 Psmb3 Mbd6 Psmb2 Asxl2 Ino80 Uchl5 Psma7 Psmc6 Usp15 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Hist2h2aa1 Psmd8 Psmd3 Ogt Psmd2 Psmd1 Tgfbr1 Tgfbr2 Adrm1 Sem1 H2ac20 Nedd8 Smad7 Kdm1b H2ac12 H2ac11 Bap1 H2ac15 H2ac21 H2ac25 Hist1h2af H2ac1 Bard1 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451307 Activation of Na-permeable kainate receptors Grik2 Grik1 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 96%140179 Amine Oxidase reactions Maoa Maob Paox SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants Nrg3 Cdc37 Erbin Nras Gab1 Nrg1 Plcg1 Sos1 Hras Egfr Pik3ca Erbb2 Egf Shc1 Ereg Hbegf Btc Hsp90aa1 Pik3r1 Nrg2 Nrg4 CO-INHIBITION BY BTLA%REACTOME DATABASE ID RELEASE 96%9927353 Co-inhibition by BTLA Btla Ptpn6 Tnfrsf14 Ptpn11 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9940465 ChAHP complex assembly Chd4 H2bu2 H2ac12 H2ac11 Cbx1 Adnp2 Adnp H2ac15 H3c7 H2bc14 H2bc9 H2ax H2bc7 H2ac20 H2bc8 H2bc3 H2bc21 Hist1h2bp H2bc26 Hist2h2aa1 H2aj Cbx3 H2ab2 RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696273 RND1 GTPase cycle Frs2 Tfrc Kidins220 Arhgap35 Frs3 Ptpn13 Muc13 Txnl1 Rbmx Flot2 Plekhg5 Grb7 Lemd3 Vangl2 Dsp Aldh3a2 Epsti1 Stip1 Depdc1b Rnd1 Wdr6 Rras2 Epha2 Stmn2 Kif14 Ccdc88a Tmem59 Arhgap5 Fam83b Cav1 Ubxn11 Plxna1 Fam135a Cpd Dlg5 Vangl1 Ankrd26 Pkp4 Pik3r1 Pik3r2 Rasal2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 96%428890 Role of ABL in ROBO-SLIT signaling Cap1 Slit2 Abl2 Abl1 Clasp1 Clasp2 Robo1 Cap2 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674404 Sorafenib-resistant PDGFR mutants Pdgfra TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding Arrb1 Necap1 Gbf1 Hip1r Snx9 App Clint1 Pik3c2a Chmp2a Clta Picalm Cltc Gak Ap1m2 Arf1 Ap1m1 Dnajc6 Clvs1 Ap1s3 Clvs2 Ap1s2 Ap1b1 Dnase2a Cltb Ap1s1 Ctsz Ap1g1 Vamp7 Bloc1s1 Vamp8 Ap4s1 Rab5c M6pr Txndc5 Hgs Ap1g2 Ap4m1 Dnm2 Sh3gl2 Hspa8 Ap4e1 Ftl1 Fth1 Cpd Tbc1d8b Sh3d19 Ocrl Golgb1 Ap3s1 Tpd52l1 Igf2r Napa Dtnbp1 Yipf6 Snapin Tfrc Snx2 Snx5 Bloc1s3 Bloc1s4 Bloc1s6 Acbd3 Pum1 Sort1 Snap23 Vamp2 Gns Ap3b1 Stx4 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 96%264870 Caspase-mediated cleavage of cytoskeletal proteins Casp6 Gsn Vim Casp3 Casp8 Casp7 Gas2 Dbnl Add1 Plec Sptan1 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis Nr1h3 Rxrb Nrip1 Rxra Pck1 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p Alg11 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 96%381119 Unfolded Protein Response (UPR) Arfgap1 Gfpt1 Ccl12 Acadvl Tln1 Dnajc3 Eif2s3x Eif2s2 Eif2s1 Calr Preb Sec31a Creb3l3 Extl2 Gosr2 Extl3 Shc1 Hspa5 Cebpb Gsk3a Atp6v0d1 Add1 Syvn1 Mydgf Extl1 Srprb Srpra Asns Yif1a Edem1 Cul7 Herpud1 Atf3 Eif2ak3 Dctn1 Ddx11 Cxxc1 Atf6 Pdia6 Pdia5 Creb3 Dcstamp Ern1 Klhdc3 Serp1 Cebpg Creb3l4 Creb3l1 Creb3l2 Kdelr3 Tspyl2 Fkbp14 Atf6b Ssr1 Hyou1 Hdgf Wipi1 Wfs1 Igfbp1 Tatdn2 Atf4 Crebrf Dnajb9 Exosc9 Zbtb17 Exosc8 Tpp1 Hsp90b1 Exosc5 Dis3 Dnajb11 Nfyb Exosc4 Nfya Exosc7 Ddit3 Nfyc Exosc6 Parn Ppp2r5b Exosc1 Lmna Mbtps1 Exosc3 Mbtps2 Exosc2 Dcp2 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production Cysltr2 Cysltr1 Dpep1 Dpep2 Ggt1 Ggt5 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Cdc25b Psmb6 Cdc25a Psmb1 Psmb3 Ccne1 Psmb2 Ccne2 Fzr1 Tfdp2 Tfdp1 Skp2 Psma7 Psmc6 Rb1 Psmc5 Psmc2 Psmc1 Ccnd1 Psmc4 Psmc3 Cdk4 Ubc Cdk2 Ptk6 E2f1 Ccna1 Cks1b Psmd7 Ccna2 Cables1 Psmd6 Lin54 Max Cdkn1a Psmd8 Cdkn1b Lin9 Psmd3 Psmd2 Wee1 Mnat1 Psmd1 Lin37 Adrm1 Sem1 Cul1 Ccnh Cdk7 Myc Rbl2 Akt3 Akt2 Akt1 Rbbp4 E2f4 E2f5 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME%R-HSA-5619115.5 Disorders of transmembrane transporters Slc17a8 Psma4 Psma3 Psma6 Psma5 Nup133 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Slc35a3 Psmb5 Psmb4 Psmb7 Avpr2 Psmb6 Psmb1 Avpr1b Slc1a1 Slc5a7 Psmb3 Avpr1a Psmb2 Slc3a1 Avp Slc1a3 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Gck Psmc4 Slc3a2 Psmc3 Ubc Psmd7 Psmd6 Slc6a19 Slc7a7 Psmd8 Abca1 Abca3 Psmd3 Slc22a5 Psmd2 Slc2a9 Psmd1 Slc6a14 Abcg8 Slc36a2 Adrm1 Sem1 Abcg5 Slc7a9 Slc6a20a Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Slc12a1 Rae1 Ndc1 Nup42 Erlin2 Erlin1 Nup62 Slc12a3 Slc12a6 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Cftr Slc35a1 Abcb6 Abcb4 Bsg Slc4a4 Slc33a1 Abcc6 Os9 Slc26a4 Slc26a3 Slco2a1 Slc5a5 Lmbrd1 Slc27a4 Slc39a4 Slc6a2 Slc6a5 Slc2a10 Slc16a1 Slc35a2 Kcnj11 Abcc9 Slco1b2 Sel1l Slc24a5 Slc35c1 Abca12 Slc20a2 Slc24a4 Abcd4 Slc22a12 Slc29a3 Abcb11 Rnf185 Derl3 Slc17a5 Derl2 Derl1 Vcp Slc40a1 Abcd1 Cp Rhag Slc4a1 Erlec1 Nup37 Nup160 Gckr Slc26a2 Slc11a2 Nup43 Ranbp2 Heph Rnf5 Hk1 Nup107 Slc24a1 Abcc2 Slc9a9 Slc9a6 Slc34a1 Slc2a1 Slc34a3 Slc34a2 Slc2a2 Slc5a1 Nup85 Slc6a3 Abcc8 Slc22a18 Apoa1 Sec13 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 96%72165 U12 Dependent Splicing Sf3b1 Ybx1 Sf3b2 Sf3b3 Sf3b4 Sf3b5 Srsf1 Sf3b6 Ddx42 Snrnp25 Snrnp40 Zmat5 Eftud2 Snrnp48 Ddx23 Snrnp35 Zrsr2 Rnpc3 Srsf7 Pdcd7 Srsf6 Srsf2 Snrpb Txnl4a Snrpd2 Snrpd1 Snrpd3 Snrnp200 Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Polr2b Polr2g Polr2h Polr2e Prpf6 Polr2f Polr2k Polr2i Polr2j Zcrb1 Prpf8 Gtf2f2 Gtf2f1 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) Kcnk3 Kcnk9 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins Ccr6 Defb47 Defb14 Ccr2 Defb36 Tlr1 Defb25 Defb15 Tlr2 Defb18 Defb29 Defb19 Defb23 Defb12 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME%R-HSA-5609975.6 Diseases associated with glycosylation precursor biosynthesis Gfpt1 Pgm1 Srd5a3 Nus1 Dhdds Galk1 Dpm1 Pmm2 Dpm2 Mpi Dpm3 Galt Gne Dolk Gale Galm RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 96%9665250 Resistance of ERBB2 KD mutants to AEE788 Erbb2 Cdc37 Erbin Hsp90aa1 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112122.3 ALKBH2 mediated reversal of alkylation damage Alkbh2 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9702509 FLT3 mutants bind TKIs Flt3 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181430 Norepinephrine Neurotransmitter Release Cycle Rab3a Slc18a2 Cplx1 Unc13b Slc22a2 Slc22a1 Maoa Snap25 Syt1 Ppfia2 Ppfia4 Vamp2 Ppfia1 Stx1a DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 96%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 Sdc1 Gpc1 Ncan Bgn Cspg5 Gpc3 Cspg4 Gpc2 Agrn Dcn Hspg2 Bcan Gpc5 Sdc4 Vcan Sdc3 Gpc4 Sdc2 Gpc6 B3galt6 HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones Riox2 Kdm4d Kdm7a Kdm2b Kdm5d Kdm2a Kdm3b Kdm5c Phf8 Kdm4a Arid5b H3c7 Jmjd6 Kdm5b Kdm1a Kdm5a Kdm1b Kdm6a Kdm3a Kdm4b Kdm6b Phf2 Kdm4c ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 96%9918476 Assembly and Release of Dengue Virus Virions Gbf1 Furin Ybx1 Kdelr1 Tsg101 Clint1 Lyn SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling Myl6 Rock2 Arhgap35 Rock1 Myh14 Rhob Myh10 Sema4d Rnd1 Rras Myh9 Rhoc Arhgef11 Limk1 Plxnb1 Limk2 Rhoa Myl12a Met Erbb2 Myl12b Rac1 Myh11 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME%R-HSA-4717374.4 Defective DPM1 causes CDG-1e Dpm1 Dpm2 Dpm3 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 96%499943 Interconversion of nucleotide di- and triphosphates Nme2 Nme1 Guk1 Rrm2b Txnrd1 Tyms Txn Dtymk Nudt13 Rrm1 Ak1 Rrm2 Nme3 Ak2 Glrx Ak5 Nme4 Ak7 Dctpp1 Dctd Cmpk1 Ak8 Nme6 Ctps2 Ctps1 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 96%5689877 Josephin domain DUBs Vcp Prkn Atxn3 Rad23a Rad23b Ubc Josd2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis Mogat1 Gk Lpin3 Gpat2 Lpin2 Lpin1 Mogat2 Gk2 Dgat2 Dgat1 Gpam SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III Tubb6 Tubb3 Tubb1 Tubb4b Tuba1b Tubb4a Tuba1a Tuba1c Spast Tubal3 Lemd2 Cc2d1b Chmp2a Ist1 Tubb2b Chmp3 Tubb2a Chmp7 Chmp6 Tuba4a Chmp4c Chmp4b Tuba8 Vps4a Tuba3b SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose Dpm1 Dpm2 Dpm3 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 96%168181 Toll Like Receptor 7 8 (TLR7 8) Cascade Tlr4 Irf7 App Ikbkb Jun Peli1 Ikbkg Map3k7 Ticam2 Traf2 Ticam1 Cd14 Nfkb1 Skp1 Fbxw11 Rela Btrc Casp8 Ubc Nfkbib Irak1 Nfkbia Cul1 Traf6 Ube2n Chuk Ube2v1 Trp53 Tab3 Tab2 Tab1 Rps6ka1 Tifa Alpk1 Nfkb2 Fos Mapk9 Mapk7 Mapk8 Elk1 Map3k8 Tasl Irf5 Mapk1 Mapk3 Rps6ka3 Mapkapk3 Rps6ka2 Mapkapk2 Map2k7 Mapk14 Map2k6 Ppp2cb Ppp2ca Map2k4 Slc15a4 Map2k3 Mapk10 Map2k1 Mapk11 Ripk2 Myd88 Rps6ka5 Tlr9 Nkiras1 Atf2 Nkiras2 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Ppp2r1a Peli2 Peli3 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Usp18 Tlr8 Tlr7 Ppp2r5d Ly96 Mef2c BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium Bbs10 Lztfl1 Bbs12 Tcp1 Arl6 Mkks Rab3ip Ttc8 Bbs2 Bbs1 Cct3 Cct2 Bbs9 Mchr1 Cct8 Bbs7 Cct5 Smo Bbs5 Cct4 Sstr3 Bbs4 PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.6 PI3K AKT activation Pik3ca Ngf Irs1 Irs2 Ntrk1 Pik3r1 Pik3cb Pik3r2 Rhoa SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.5 Signaling by NOTCH1 Arrb1 Hey2 Hey1 Mib2 Ncor2 Skp1 Mamld1 Itch Notch1 Rbx1 Ubc Kat2b Numb Kat2a Cul1 Tle4 Tle2 Dtx1 Tle1 Dtx2 Dlk1 Dner Hdac2 Hdac1 Hdac5 Hdac4 Myc Hdac7 Hdac6 Hdac9 Dtx4 Hdac8 Ncor1 Cntn1 Dll4 Hes1 Hif1a Jag2 Jag1 Adam10 Ep300 Cdk8 Neurl1b Tbl1x Adam17 Neurl1a Dll1 Mib1 Hdac3 Tbl1xr1 Psen1 Psen2 Ncstn Maml1 Aph1b Maml2 Heyl Hdac11 Hdac10 Hes5 Rbpj Ccnc Crebbp Arrb2 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357956 TNFR1-induced NF-kappa-B signaling pathway Usp2 Tab3 Tab2 Tab1 Sharpin Usp21 Traf1 Tnf Spata2 Rnf31 Tnfrsf1a Usp4 Rbck1 Cyld Ikbkb Otud7b Tnfaip3 Birc3 Birc2 Ikbkg Tradd Map3k7 Traf2 Xiap Optn Ripk1 Rack1 Chuk AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C Psma4 Psma3 Psma6 Psma5 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdc27 Ube2d1 Psmb5 Cdc16 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Psmb2 Fzr1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 96%162588 Budding and maturation of HIV virion Ppia Ubap1 Tsg101 Chmp4c Mvb12a Chmp4b Mvb12b Vps37a Vps37b Vps37c Vta1 Vps37d Ubc Pdcd6ip Chmp5 Vps28 Chmp2a Vps4a Nedd4l Vps4b Chmp3 Chmp7 Chmp6 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer Il10ra Ptpn6 Stat5a Irf4 Hdac1 Prf1 Foxm1 Bcl2a1d Zc3hc1 Icos Tnrc6c Stat3 Junb Skp1 Mov10 Gzmb Ago4 Ago3 Npm1 Ago2 Ago1 Rbx1 Rb1 Dnmt1 Twist1 Zap70 Mapk1 Mapk3 Cul1 Cebpb PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism Tymp Nt5c Nt5c1a Upb1 Agxt2 Upp1 Upp2 Nt5e Dpys Dpyd Nt5m THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-HSA-428930.4 Thromboxane signalling through TP receptor Gngt1 Gngt2 Gna11 Gng10 Gna15 Gna14 Gng3 Gng2 Gnb2 Gnaq Gnb1 Tbxa2r Gng4 Gnb4 Gnb3 Gna13 Gng7 Gnb5 Aamp Gng11 Gng8 Gng12 Gng13 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%381042 PERK regulates gene expression Ccl12 Eif2s3x Asns Eif2s2 Eif2s1 Herpud1 Atf3 Eif2ak3 Atf6 Cebpg Igfbp1 Atf4 Exosc9 Exosc8 Hspa5 Exosc5 Dis3 Nfyb Exosc4 Nfya Exosc7 Nfyc Ddit3 Exosc6 Parn Exosc1 Exosc3 Exosc2 Dcp2 Cebpb RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway Dhrs4 Aldh1a3 Rdh10 Akr1c18 Aldh8a1 Rdh13 Rdh14 Cyp26b1 Cyp26c1 Rdh16f2 Cyp26a1 Rdh5 Aldh1a1 Crabp1 Dhrs9 Sdr16c5 Adh4 Dhrs3 Adh1 Aldh1a2 Rdh11 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling Nrg3 Shc1 Ereg Hbegf Btc Nras Nrg1 Sos1 Hras Nrg2 Nrg4 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%2161517 Abacavir transmembrane transport Abcg2 Slc22a2 Slc22a3 Slc22a1 Abcb1a TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Ccne1 Trp53 Ccne2 E2f7 Cdk2 E2f8 E2f1 Ccna1 Ccna2 Cdkn1a Cdkn1b Pcbp4 Zfp385a MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 96%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes Cacnb1 Cacnb2 Gja1 P2rx7 Itga5 Itgb3 Panx1 Cacng7 Itgav Itgb1 Cacna1h Akt1 Hspg2 Cacna2d1 Spp1 Cacnb3 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%2029485 Role of phospholipids in phagocytosis Cd3g Pld4 Itpr3 Prkcd Itpr2 Pld2 Itpr1 Plcg1 Pik3cb Plcg2 Ahcyl1 Fcgr1 Pik3ca Plpp4 Fcgr3 Plpp5 Fcgr4 Pld3 Syk Pik3r1 Pik3r2 Pla2g6 Pld1 Prkce LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 96%3304347 Loss of Function of SMAD4 in Cancer Smad2 Smad3 Smad4 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%937042 IRAK2 mediated activation of TAK1 complex Tab3 Tab2 Map3k7 Tab1 Traf6 Irak2 Ubc INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 96%2995383 Initiation of Nuclear Envelope (NE) Reformation Ppp2ca Emd Lemd3 Lbr Ccnb2 Ankle2 Lemd2 Vrk1 Ppp2r2a Sirt2 Kpnb1 Cdk1 Banf1 Lmnb1 Ppp2r1a REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 96%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 Arhgap10 Pak2 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 96%114452 Activation of BH3-only proteins Trp73 Trp53 Ppp3r1 Mapk8 Trp53bp2 Ywhah Bcl2 Akt3 Akt2 Akt1 Bcl2l11 Trp63 Ywhae Dynll1 Dynll2 Bid Ywhaz Bad Tfdp2 Tfdp1 Ppp1r13b E2f1 Bmf Sfn Ppp3cc Ywhab Ywhag SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702624 sorafenib-resistant FLT3 mutants Flt3 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 96%9032500 Activated NTRK2 signals through FYN Rac1 Src Bdnf Ntrk2 Dock3 Grin2b G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-HSA-392451.5 G beta:gamma signalling through PI3Kgamma Gngt1 Gngt2 Gng10 Pik3cg Rhoa Akt3 Gng3 Akt2 Gng2 Gnb2 Akt1 Gnb1 Gng4 Gnb4 Gnb3 Gng7 Pik3r5 Gnb5 Pdpk1 Pik3r6 Gng11 Gng8 Gng12 Gng13 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling Pdcd4 Jak2 Pitpna Il12rb1 Il12rb2 Ppia Rap1b Il27 Capza1 Il27ra Crlf1 Cnn2 Pak2 Tyk2 Hnrnpf Sod2 Stat3 Stat1 Lmnb1 Arf1 Canx Tcp1 Vamp7 Psme2 Ca1 Snrpa1 Anxa2 Gsto1 Il6st P4hb Rala Il12b Il12a Ifng Hspa9 Msn Il10 Jak1 Taldo1 Bola2 Stat4 Il23r Hnrnpa2b1 Serpinb2 Aip Mtap Cfl1 Mif Hnrnpdl Lcp1 Ebi3 DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 96%5609976 Defective GALK1 causes GALCT2 Galk1 AGGREPHAGY%REACTOME DATABASE ID RELEASE 96%9646399 Aggrephagy Cftr Ube2v1 Cetn1 Pcnt Dync1h1 Vcp Park7 Hsf1 Dync1li2 Ubc Dync1i2 Dync1li1 Dync1i1 Hdac6 Ift88 Prkn Arl13b Dynll1 Dynll2 Hsp90aa1 Ube2n FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190370.4 FGFR1b ligand binding and activation Tgfbr3 Fgf22 Fgf2 Fgf1 Fgf10 Fgf3 Gipc1 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 96%912526 Interleukin receptor SHC signaling Jak2 Il2 Csf2 Il2ra Il3ra Jak3 Inppl1 Il2rb Ptpn6 Csf2rb2 Csf2ra Pik3cb Sos1 Il5 Pik3cd Il5ra Gab2 Pik3ca Shc1 Jak1 Il2rg Inpp5d Pik3r1 Pik3r2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism Cyb5r3 Slc23a2 Slc2a3 Gsto1 Cyb5a Slc23a1 Gsto2 Slc2a1 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 96%913709 O-linked glycosylation of mucins St6galnac3 Galnt3 St6galnac4 Muc15 St6galnac2 Muc13 St3gal4 Galnt12 St3gal2 B3gnt9 B3gnt8 St3gal1 Qtgal B3gnt6 B3gnt5 Galntl5 St6gal1 Galnt2 Galnt5 Galnt4 Galnt7 C1galt1 Galnt6 Galnt10 A4gnt C1galt1c1 B4galt5 Galnt17 Galnt18 B4galt6 Galnt15 Galnt16 Galnt13 Galnt14 Galnt11 Gcnt7 Gcnt3 Chst4 Muc1 Gcnt1 B3gnt3 B3gnt7 Muc4 Muc6 B3gnt4 Muc20 B3gnt2 Galnt1 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-HSA-8949215.3 Mitochondrial calcium ion transport Afg3l2 Smdt1 Mcub Pmpcb Vdac2 Yme1l1 Vdac3 Spg7 Micu2 Micu3 Pmpca Vdac1 Phb2 Letm1 Slc8a3 Micu1 Parl Maip1 Stoml2 Mcu Phb1 Akap1 Slc8b1 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 96%1483248 Synthesis of PIPs at the ER membrane Mtmr2 Pi4ka Sbf1 Sacm1l Pi4k2b ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 96%111452 Activation and oligomerization of BAK protein Bak1 Bid SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors Scarf1 Calr Hyou1 Hsp90aa1 Hsph1 Apob MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a St3gal2 St3gal1 St6gal1 St6galnac3 St6galnac4 St6galnac2 St3gal4 Galnt1 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME DATABASE ID RELEASE 96%5339562 Uptake and actions of bacterial toxins Map2k4 Gucy2c Map2k2 Nherf4 Map2k1 Pdcd6ip Txnrd1 Stx1b Hbegf Sv2c Furin Syt2 Snap25 Sv2b Syt1 Eef2 Sv2a Vamp1 Hsp90aa1 Vamp2 Map2k7 Stx1a Cd9 Hsp90ab1 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 96%139853 Elevation of cytosolic Ca2+ levels Trpc3 Stim1 P2rx6 P2rx5 Itpr3 P2rx3 Itpr2 P2rx7 P2rx2 Itpr1 P2rx4 P2rx1 Trpc6 Trpc7 Orai1 Orai2 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Trp73 Ndrg1 Trp53 Birc5 Rabggta Rabggtb Trp53bp2 Bcl2l14 Ppp1r13b Trp63 Chm Perp Bcl6 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 96%9012546 Interleukin-18 signaling Alox5 Il18bp Il4 Il18r1 Il13 Il18rap Il18 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943965 CHD3, CHD4, CHD5 subfamily H2bc9 H2bc7 H2bc8 H2bc3 Gatad2a Gatad2b H2ab2 Mbd3 H2bu2 Cbx1 Adnp2 Adnp Mta1 Mta3 Nr2c2 Hist2h2aa1 Cbx3 Phf6 Zfp592 Tcf19 Cdk2ap1 G6pc1 Cdk2ap2 Nr2f2 Mbd2 Zmynd8 Ikzf3 H2bc14 Znf687 Ikzf2 H2ac20 Ikzf1 Pwwp2a Chd5 Mbd3l1 Hdac2 Hdac1 Zfp827 Pwwp2b Ube2i H2bc21 H2bc26 Rbbp4 Rbbp7 Chd3 Chd4 H2ac12 H2ac11 H2ac15 H3c7 H2ax Fbp1 Mta2 Hist1h2bp H2aj Pck1 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins Zfp141 Znf382 H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Hdac2 Hdac1 H2bc3 Zfp457 Ube2i H2bc21 Gatad2a H2bc26 Gatad2b Rbbp4 Rbbp7 Trim28 H2ab2 Mbd3 Chd3 ZNF418 H2bu2 Chd4 Setdb1 H2ac12 Zfp324 H2ac11 Mta1 Zfp454 Zfp317 Atf7ip H2ac15 Mta3 H3c7 H2ax Zfp708 Mta2 Hist1h2bp Hist2h2aa1 Cbx5 H2aj Zfp354a INTERLEUKIN-7 SIGNALING%REACTOME%R-HSA-1266695.10 Interleukin-7 signaling Irs1 Socs2 Irs2 Cish Jak3 H3c7 Stat5a Stat5b Hgf Brwd1 Tslp Crlf2 Il7 Stat3 Rag2 Jak1 Rag1 Il2rg Socs1 Smarca4 Pik3r1 Pik3r2 Il7r KIDNEY DEVELOPMENT%REACTOME%R-HSA-9830369.1 Kidney development Gata3 Wnt11 Hnf4a Fgf2 Hnf1b Slit2 Ret Hoxa11 Hoxd11 Hoxc11 Grem1 Robo2 Six1 Hoxa6 Npnt Jag1 Foxc2 Foxc1 Itga8 Gdnf Six2 Dll1 Id4 Pcdh19 Wnt4 Gfra1 Pou3f3 Mecom Irx1 Ctnnb1 Irx2 Emx2 Plac8 Osr1 Hoxb4 Pax2 Bmp4 Eya1 Lhx1 Pax8 Sall1 Wfdc2 Itgb1 Wnt9b Wt1 Lfng Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors Eif4b Dis3l2 Eif4e Eif4a2 Eif4a1 Eif4a3 Pabpn1 Pabpc1 Tut7 Tut4 Eif4g1 Paip1 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 96%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation Pak2 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate Phyh Slc25a17 Hacl1 Slc27a2 Pecr ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME%R-HSA-168275.6 Entry of Influenza Virion into Host Cell via Endocytosis Clta Cltc OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956553 OTC main chain variants cause OTC deficiency Otc DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 96%1489509 DAG and IP3 signaling Prkaca Prkar2b Itpr3 Camkk1 Itpr2 Camkk2 Itpr1 Plcg1 Prkca Prkcg Prkx Prkar1a Prkacb Camk4 Prkce Prkar2a Grk2 Pde1b Pde1c Prkcd Adcy3 Pde1a Adcy4 Adcy1 Adcy2 Adcy7 Camk2g Adcy8 Adcy5 Camk2d Adcy6 Ahcyl1 Camk2b Adcy9 Camk2a Prkar1b DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME%R-HSA-5579026.4 Defective CYP11A1 causes AICSR Cyp11a1 Fdx1 Fdxr Fdx2 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%8849472 PTK6 Down-Regulation Ptk6 Ptpn1 Srms GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 96%1630316 Glycosaminoglycan metabolism Prelp St3gal6 Galns Lum Sgsh Xylt1 Xylt2 Chst11 Chst12 Glce Chsy1 Uxs1 Chsy3 Chst13 Chst14 Chst15 St3gal4 Ndst1 Ndst2 St3gal2 Ndst3 St3gal1 Ndst4 Omd Hspg2 Slc35d2 Sdc4 Sdc3 Sdc2 Hs3st3b1 Gns B4galt4 B4galt5 B4galt6 B4galt7 Slc26a11 B4gat1 B4galt1 B4galt2 B4galt3 Ext2 Ext1 B3gnt3 Sdc1 B3gnt7 B3gnt4 B3gnt2 Chst1 Chst3 Chst2 Chst5 Chst7 Hyal5 Hyal2 Abcc5 Hexa Has1 Hexb Idua Gpc1 Stab2 Ncan Bgn Cspg5 Gpc3 Cspg4 Gpc2 Dcn Has2 Bcan Gpc5 Vcan Has3 Gpc4 Glb1 Hyal4 Fmod Hyal3 Gpc6 Ids Cd44 Hyal1 Slc17a5 Glb1l3 Glb1l2 Arsb Gusb Hs6st3 Hs6st2 Hs6st1 Lyve1 Papss2 Papss1 Extl2 Naglu Kera Extl3 Csgalnact1 Chpf Agrn Csgalnact2 Chp1 B3galt6 Slc26a2 Slc26a1 Cemip Fam20b Hpse Hs2st1 Pxylp1 Ust Ogn Slc35b3 Slc35b2 Dse Slc9a1 Hmmr Hs3st3a1 Dsel Hs3st4 Hs3st1 Hs3st2 Hs3st5 Hs3st6 Hpse2 B3gat3 B3gat1 B3gat2 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 96%9005895 Pervasive developmental disorders Prkaca Ncor2 Sin3a Hdac3 Ncor1 Gps2 Tbl1xr1 Camk4 Hdac1 Tbl1x RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol Nhp2 Wdr75 Dimt1 Emg1 Dhx37 Gar1 Pno1 Pdcd11 Utp20 Nop14 Utp25 Rcl1 Nop10 Tbl3 Nol11 Wdr3 Bud23 Dcaf13 Utp15 Heatr1 Utp11 Nat10 Ddx52 Utp18 Wdr43 Wdr46 Noc4l Ddx49 Ddx47 Thumpd1 Tsr3 Rrp36 Nop2 Nol6 Utp14a Mphosph10 Trmt112 Bms1 Krr1 Utp3 Utp4 Utp6 Nop58 Nop56 Rps14 Rrp9 Pwp2 Fbl Imp3 Imp4 Rps9 Rps7 Dkc1 DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME%R-HSA-9853846.1 Defective ANO6 does not expose PS, PE on the platelet membrane Ano6 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane Rab8a Ywhah Prkaa2 Akt2 Rab11a Akt1 Stxbp3 Ywhae Exoc3 Rab4a Exoc4 Exoc5 Snap23 Exoc6 Vamp2 Exoc1 Prkab2 Myo5a Exoc2 Prkab1 Ywhaz Exoc7 Exoc8 Prkag3 Myh9 Prkag1 Prkag2 Rac1 C2cd5 Sfn Slc2a4 Kif3a Ywhab Tbc1d1 Kif3b Lnpep Rab10 Ywhag Rab13 Kifap3 Tbc1d4 Myo1c Rab14 Ralgapb Aspscr1 Rala Stx4 TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 96%9839394 TGFBR3 expression Sp1 Smad3 Smad4 Myog Myod1 Tcf3 Hells Rxra Rara Tgfbr3 Tnrc6c Myf6 Tcf4 Myf5 Klf16 Tnrc6a Tnrc6b Mycn Ep300 Mov10 Ago4 Ago3 Ago2 Ago1 Tcf12 GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70370 Galactose catabolism Pgm1 Galt Galk1 Gale Akr1b1 Galm DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 96%3359469 Defective MTR causes HMAG Mtrr Mtr PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 96%433692 Proton-coupled monocarboxylate transport Slc16a8 Slc16a7 Slc16a1 Bsg Slc16a3 Emb REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 96%1433617 Regulation of signaling by NODAL Lefty1 Nodal Acvr1c Dand5 Acvr2a Acvr1b Acvr2b Cer1 Lefty2 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 96%1483196 PI and PC transport between ER and Golgi membranes Pitpnb LIPOPHAGY%REACTOME%R-HSA-9613354.4 Lipophagy Prkaa2 Plin3 Plin2 Prkag3 Prkab2 Prkab1 Prkag1 Hspa8 Prkag2 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME DATABASE ID RELEASE 96%9637687 Suppression of phagosomal maturation Nos2 Atp6v1h Coro1a Vps33b Kpna1 Kpnb1 Rab5a Hgs Rab7 Ubc POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 96%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Stat3 Fgf2 Foxd3 Sox2 Zic3 Sall4 Epha1 Pou5f1 Sall1 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation Atp6v1h Ap2a2 Ap2s1 Ap2a1 Ap2m1 Lck Cd4 Arf1 Ap2b1 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants Alk SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 96%2559582 Senescence-Associated Secretory Phenotype (SASP) Mapk7 H2bc9 H2bc7 H2bc8 Jun H2bc3 Anapc5 Cdkn2a Anapc4 Cdkn2b Anapc1 Stat3 Cdkn2c Anapc2 Anapc11 Ube2c Ehmt2 Anapc10 H2ab2 Ehmt1 Anapc7 Nfkb1 Cdc27 Ube2d1 Cdc16 Anapc16 Il6 Ube2e1 Cdc23 H2bu2 Anapc15 Rela Fzr1 Cdk6 Cdk4 Ubc Cdk2 Ccna1 Ccna2 Il1a Mapk1 Cdkn1a Hist2h2aa1 Mapk3 Cdkn1b Igfbp7 Rps6ka3 Rps6ka2 Cebpb H2bc14 H2ac20 H2bc21 H2bc26 Rps6ka1 H2ac12 H2ac11 H2ac15 H3c7 H2ax Hist1h2bp Fos H2aj DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-HSA-8932504.1 DAG1 core M2 glycosylations Pomt1 Dag1 Pomt2 Mgat5b Pomgnt1 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181429 Serotonin Neurotransmitter Release Cycle Rab3a Slc18a2 Cplx1 Unc13b Syn3 Syn2 Syn1 Snap25 Syt1 Ppfia2 Ppfia4 Vamp2 Ppfia1 Stx1a DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 96%5696394 DNA Damage Recognition in GG-NER Actl6a Cetn2 Nfrkb Parp2 Ino80e Tfpt Ino80d Ino80c Ddb1 Parp1 Ino80b Actr5 Actr8 Ruvbl1 Cul4a Xpc Rad23a Cul4b Rad23b Cops4 Cops3 Cops6 Cops2 Actb Yy1 Cops8 Ino80 Cops7a Cops7b Rbx1 Ubc Cops5 Ddb2 RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 96%5625740 RHO GTPases activate PKNs Myl6 Pak1 Pkn2 H2bc9 Pkn1 H2bc7 Rhoc H2bc8 H2bc3 Ppp1r12b Ppp1r12a Ppp1r14a Ywhae H2ab2 Kdm1a Ppp1cb Cdc25c H2bu2 Myh14 Myh10 Hist2h2aa1 Ywhab Ywhag Pdpk1 Kdm4c H2bc14 H2ac20 Ywhah Ar Rhoa H2bc21 H2bc26 Ywhaz H2ac12 H2ac11 H2ac15 Rhob Ncoa2 H3c7 H2ax Myh9 Myl12a Myl12b Rac1 Hist1h2bp Myh11 Sfn H2aj Pkn3 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD Bckdhb Bckdha Dbt Dld Ppm1k REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 96%3371453 Regulation of HSF1-mediated heat shock response Rpa2 Rpa3 Atm Nup133 Ywhae Hspa1a Hspa8 Hspa5 Mapk1 Mapk3 Nup37 Mapkapk2 Dnajc7 Nup160 Hsph1 Dnajc2 Hikeshi Hspa14 Nup43 Gsk3b Hspa13 Rps19bp1 Ranbp2 St13 Hspa12b Hspa12a Bag5 Nup93 Bag4 Hspa9 Nup50 Hsf1 Nup35 Bag3 Nup54 Bag1 Pom121 Nup205 Dnajb6 Nup188 Dnajb1 Tpr Hspa4l Nup107 Rae1 Hspa4 Ndc1 Ccar2 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Hspa1l Nup85 Sec13 Bag2 Hspa2 Sirt1 Rpa1 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%449836 Other interleukin signaling Csf3r Il10rb Casp3 Tyk2 Sdc1 Csf1r Cd4 Csf3 Il34 Ptprz1 Il16 Stxbp2 Jak1 Prtn3 Txlna Snap25 Ifnlr1 Stx3 Vamp2 Stx1a Csf1 Stx4 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 96%9610379 HCMV Late Events H2bc9 H2bc7 H2bc8 H2bc3 Nup133 Chmp2a Hnrnpk Chmp3 Chmp7 Chmp6 H2bu2 Chmp4c Chmp4b H2bc18 Hist2h2aa1 Nup37 Nup160 Nup43 Ranbp2 H2bc14 Nup93 H2ac20 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr H2bc21 Nup107 Rae1 Ndc1 H2bc26 Nup42 Nup62 Nup88 Chmp1a Aaas Nup214 Nup210 Nup155 Nup153 Cebpd H2ac12 H2ac11 Vps36 Ubap1 Tsg101 H2ac15 H2ac21 Mvb12a H3c7 Mvb12b H2ac25 Vps37a Vps37b Hist1h2af Nup85 Vps37c Vps37d H2ac1 Snf8 Vps25 Vps28 Hist1h2bp Vps4a Sec13 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70921 Histidine catabolism Ftcd Hnmt Carnmt1 Hal Aoc1 Uroc1 Hdc Amdhd1 Carns1 EICOSANOIDS%REACTOME DATABASE ID RELEASE 96%211979 Eicosanoids Cyp4f14 Ptgis Cyp4a32 Tbxas1 Cyp4f15 Cyp8b1 Cyp4f39 Cyp4f17 Cyp4a12b Cyp4f3 Cyp4f40 Cyp4b1 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER Pcna Rfc4 Rpa2 Rfc1 Rfc2 Pold4 Pold3 Xrcc1 Lig3 Rpa3 Pole3 Polk Pole2 Ubc Pole Pole4 Lig1 Rfc5 Pold2 Pold1 Rfc3 Rpa1 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%196108 Pregnenolone biosynthesis Cyp11a1 Stard3nl Stard4 Stard3 Star Fdx1 Fdxr Tspo Akr1b1 Fdx2 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport Kcnj11 Abcc9 Sel1l Abca12 Abcc4 Abcc5 Psma4 Psma3 Psma6 Psma5 Abca6 Psma2 Psma1 Eif2s3x Eif2s2 Psmd12 Eif2s1 Psmd11 Psmd14 Psmd13 Rnf185 Derl3 Psmb5 Psmb4 Abcg1 Derl2 Psmb7 Derl1 Psmb6 Psmb1 Psmb3 Psmb2 Vcp Psma7 Psmc6 Abcd1 Psmc5 Abcb10 Psmc2 Abcf1 Psmc1 Abcb5 Psmc4 Abcb8 Psmc3 Abcb9 Ubc Abcg4 Pex3 Psmd7 Abca8b Psmd6 Abcc10 Abcd2 Abcd3 Psmd8 Erlec1 Psmd3 Abca2 Abca3 Psmd2 Abca5 Psmd1 Abca4 Abca9 Abcg8 Abcc1 Adrm1 Abca7 Abcg5 Sem1 Rnf5 Erlin2 Abcc2 Erlin1 Cftr Abcc3 Abcb1a Abcb6 Abcb4 Pex19 Os9 Abcc6 Apoa1 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451306 Ionotropic activity of kainate receptors Dlg1 Dlg3 Grik5 Dlg4 Grik2 Grik1 Grik4 Grik3 Ncald PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes Ccne1 Ccne2 Rb1 Cdk2 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 96%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) Slc1a1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 96%216083 Integrin cell surface interactions Col4a1 Fgb Fga Col4a2 Col9a2 Itgb5 Col9a3 Lum Pecam1 Fgg Col9a1 Itgb3 Fn1 Vtn Spp1 Cd44 Itga8 Itgb8 Itgb6 Cdh1 Kdr Itgav Agrn Tnc Itgax Comp Itgam Itgae Itgad Itgb7 Itgb2 Icam5 Icam4 Cd47 Jam3 Jam2 Itga11 Itga9 Ibsp Itga10 Fbn1 Itga5 F11r Itga2b Itga4 Icam2 Hspg2 Itga7 Itga6 Icam1 Itga3 Itga1 Itga2 Itgal Col16a1 Col18a1 Col13a1 Itgb1 Bsg Col4a3 Col23a1 Thbs1 Vcam1 Col4a4 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis Srebf2 Havcr2 Angptl4 Plin1 Nfkb1 Fabp4 Ucp1 Rela Hnrnpu Ncoa3 Elovl3 Mta1 Cidea Mta3 Prdm16 Ebf2 Ppargc1b Bmp7 Zfp423 Lpl Wnt10b Smad1 Adipoq Nr2f2 Smad4 Ppara Pparg Rxra Hdac1 Cd36 Chd3 Chd4 Wnt1 Med9 Mta2 Cdk19 Med13l Slc2a4 Med8 Med4 Med23 Med6 Med24 Med25 Med20 Med26 Med27 Med12 Tgfb1 Med13 Med14 Med10 Med15 Med16 Med17 Ncor2 Gatad2a Gatad2b Mbd3 Ccnd3 Cdk4 Med22 Med21 Med28 Med29 Med11 Med19 Med30 Med18 Med31 Cebpb Tnf Ebf1 Egr2 Thrap3 Hdac2 Zfp638 Fam120b Zfp467 Lep Rbbp4 Ncor1 Rbbp7 Helz2 Carm1 Cdk8 Ep300 Tbl1x Cebpd Cebpa Klf5 Hdac3 Ncoa2 Ncoa1 Tbl1xr1 Smarcd3 Ncoa6 Med1 Cox7a1 Ppargc1a Klf4 Ccnc Crebbp Chd9 Pck1 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-HSA-6803211.2 TP53 Regulates Transcription of Death Receptors and Ligands Ppp1r13b Trp73 Trp53 Fas Trp63 Igfbp3 Trp53bp2 Tmem219 Tnfrsf10b DISEASES OF GLYCOSYLATION%REACTOME%R-HSA-3781865.4 Diseases of glycosylation Prelp Lum Galnt3 Muc15 Muc13 Pomgnt1 Galnt12 Adamts1 Adamts5 Adamts4 Adamts3 Adamts2 Adamts8 Adamts7 Adamts6 Sema5a Sema5b C1galt1 Thsd1 Thbs2 C1galt1c1 Thsd4 Adamts13 Adamts14 Adamts15 Large1 Adamts16 Cfp Adamts18 Notch1 Adamts19 Spon2 Muc1 Spon1 Adamts10 Sbspon Adamts12 B3glct Pmm2 Mpi Muc4 Muc6 Thsd7a Muc20 Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Pomt1 Adamts20 Dag1 Thsd7b Lfng Pomt2 Chsy1 Mgat2 Mogs Chst14 Alg11 Galt Man1b1 Omd Hspg2 Sdc4 Sdc3 Sdc2 Notch4 Notch2 B4galt7 Srd5a3 Notch3 B4gat1 Dhdds B4galt1 Ext2 Ext1 Sdc1 Dpm1 Dpm2 Dpm3 Ctsa Gne Dolk Gfpt1 Chst3 Neu1 Chst5 Nus1 Hexa Hexb Gpc1 Ncan Bgn Cspg5 Gpc3 Cspg4 Gpc2 Dcn Bcan Gpc5 Vcan Gpc4 Glb1 Fmod Gpc6 Alg14 Papss2 Kera Agrn B3galt6 Slc26a2 Galk1 Alg9 Alg8 Alg6 Alg3 Alg2 Ogn Alg1 Mpdu1 Rft1 Dpagt1 Pgm1 Gale Thbs1 B3gat3 Galm DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias Kcnj11 Abcc8 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome Arsb FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm Gata6 Gata4 Smad2 Ctnnb1 Smad3 Smad4 Foxa2 Cdh1 Cxcr4 Sox17 Mixl1 Eomes Tcf7l2 T Gsc SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections Sp1 Fkbp1a Gja1 Ppia Sap30l Suds3 Larp1 Brms1 Rcor1 Jak3 Sap30 Tyk2 Sap18b Blnk Arid4b Crbn Plcg2 Arid4a Cd79a Cd79b Chmp2a Ifnar1 Hmg20b Ifngr2 Ap2m1 Ifngr1 Ywhae S1pr1 Btk Sigmar1 Kdm1a Fnta Fntb Chmp3 Stat2 Ddx5 Chmp7 Il1r1 Chmp6 Fkbp4 Ap2a2 Nlrp3 Ap2a1 Itch Ripk3 Chmp4c Rbx1 Chmp4b Casp1 Ripk1 Ap2b1 Ap2s1 Syk Irak1 Pycard Cysltr1 Nrp1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nck1 Nup188 Tpr Rae1 Ndc1 Nup42 Hspg2 Nup62 Nup88 Sdc4 Sdc3 Aaas Sdc2 Nup214 Nup210 Nup155 Nup153 Atp1a2 Fxyd4 Atp1a1 Fxyd1 Atp1a3 Fxyd7 Fxyd6 Sdc1 Rps14 Rps16 Rps18 Rps19 Rpsa Sfn Atp1b1 Rps10 Kpnb1 Atp1b3 Rps11 Atp1b2 Hsp90aa1 Rps9 Rps7 Rps5 Rps25 Rps26 Rps21 Cul3 Havcr1 Ace2 Isg15 Tmprss2 Rps15a Gpc1 Gpc3 Gpc2 Rps27l Gpc5 Gpc4 Gpc6 Mbd3 Canx Rps3 Rps4x Rb1 Agrn Ifnb1 Comt Nup37 Nup160 Nup43 Pik3c3 Ranbp2 Hdac2 Ripk2 Nup107 Bcl2l1 Tlr9 Pik3r4 Rps27 Gemin7 Gemin4 Nod2 Gemin5 Il6ra Nod1 Snrpb Smn1 Snrpd2 Tkfc Snrpd1 Nup85 Irak2 Snrpd3 Gemin2 Ddx20 Tlr8 Tlr7 Sec13 Keap1 Ano10 Ano8 Ano7 Ano6 Mbl2 Ano5 Ano4 Ano2 Ano1 Sting1 Prmt1 Irf7 Ikbkb Nup133 Ikbkg Traf3 Map3k7 Ikbke Nfkb1 Rela B2m Npm1 H2-Q10 Mta1 Tjp1 Mta3 Psmc6 Ubc Tubb5 Map1lc3b Becn1 Uvrag Iscu Nfkbia Parp14 Traf6 Parp16 Ube2n Galnt1 Chuk Parp4 Parp6 Ganab Mgat5 Nr3c1 Gsk3a Parp8 Zdhhc9 Ube2v1 Parp10 Man2a1 Tab3 Parp9 Zdhhc11 Tab2 Mgat2 Tab1 Mgat1 Mogs Smad3 Golga7 Smad4 Edem2 Fut8 St6galnac3 St6galnac4 Ywhah St6galnac2 Hdac1 St3gal4 Mgat4c Ube2i Mgat4a St3gal2 Akt3 Mgat4b Akt2 St3gal1 Akt1 Man1b1 Zdhhc20 Prkcsh St6gal1 Zdhhc8 Zdhhc5 Rpn2 Zdhhc3 Rpn1 Zdhhc2 Ywhaz Chd3 Chd4 Il17rc Il17ra Vps39 Rest Vps18 Vps11 Vps16 Mta2 Cav1 Jak1 Vav1 Zcrb1 Jak2 Impdh1 Vps41 Vps45 Vhl Magt1 Pcbp2 Brd4 Tufm Nmi Gatad2a Tmem258 Gatad2b Stat1 Tlr1 Tlr2 Sftpd Ifih1 Hsp90ab1 Sike1 Rnf135 Trim25 Stt3a Mavs Stt3b Rigi Sh3kbp1 Srpk1 Rock2 Srpk2 Vcp Vps33a Vps33b Rock1 Ostc Crb3 Patj Pals1 Tusc3 Tomm70 Furin Ywhab Dad1 Ywhag Pdpk1 Ddost Gsk3b Csnk1a1 Nlrp12 Ptpn6 Sos1 Pdcd1 Rcan3 Ptpn11 H2-M5 H2-M3 Tbk1 Zbp1 Itga4 G3bp1 G3bp2 Irf3 Rbbp4 Rbbp7 Ep300 H2-Q1 Hnrnpa1 Cnbp Sar1b Bst2 Sec23a Itgb1 Il17f Il17a Nfe2l2 Ppig Sec24d Ppih Sec24c Crebbp Ppib Sec24b Sec24a MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%193993 Mineralocorticoid biosynthesis Hsd3b6 Cyp21a1 Hsd3b1 Lhb Cyp11b2 Cga LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 96%9031525 LXRs regulate gene expression to limit cholesterol uptake Mylip Nr1h2 Nr1h3 Rxrb Rxra ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 96%181431 Acetylcholine binding and downstream events Chrnd Chrne Chrng Chrna3 Chrnb4 Chrna2 Chrnb3 Chrnb2 Chrna1 Chrna6 Chrna5 Chrna4 Chrna9 SARS-COV-1-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9692914 SARS-CoV-1-host interactions Rps5 Sp1 Fkbp1a Ppia Sting1 Rps25 Pcbp2 Rps26 Rps21 Nmi Rps15a Traf3 Ywhae Ikbke Rps27l Nfkb1 Sftpd Ifih1 Sike1 Nlrp3 Trim25 Mavs Rela Rps3 Rigi Itch Rps4x Npm1 Ripk3 Psmc6 Casp1 Ubc Pals1 Tomm70 Ywhab Ywhag Nfkbia Pdpk1 Traf6 Pycard Smad3 Smad4 Rcan3 Ywhah Ube2i Tbk1 Bcl2l1 Irf3 Rps27 Ep300 Ywhaz Hnrnpa1 Bst2 Tkfc Irak2 Rps14 Rps16 Rps18 Rps19 Cav1 Rpsa Tlr7 Sfn Rps10 Kpnb1 Ppig Rps11 Ppih Ppib Rps9 Rps7 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 96%392170 ADP signalling through P2Y purinoceptor 12 Gnat3 P2ry12 Gngt1 Gngt2 Gng10 Gng3 Gng2 Gnb2 Gnb1 Gng4 Gnb4 Gnai2 Gnb3 Gng7 Gnai1 Gnb5 Gng11 Gnai3 Gng8 Gng12 Gng13 RRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72312 rRNA processing Elac2 Xrn2 Nop2 Nop58 Nop56 Rps14 Rpl4 Rps16 Las1l Rps18 Rrp1 Csnk1d Exosc9 Rps19 Ltv1 Exosc8 Mtrex Exosc5 Rpsa Rrp9 Dis3 Rpl37 Rpp38 Exosc4 Rpl39 Pwp2 Exosc7 Rps10 Bysl Exosc6 Fbl Rps11 Rpp30 Exosc1 Rpl7 Ftsj3 Exosc3 Imp3 Exosc2 Rpp21 Rpl32 Imp4 Rps9 Rpp25 Rps7 Dkc1 Rps5 Nhp2 Rpl24 Wdr75 Rpl26 Senp3 Rpl22 Isg20l2 Rpl23 Dimt1 Exosc10 Emg1 Eri1 Dhx37 Rps25 Gar1 Rps26 Pno1 Pdcd11 Utp20 Rps21 Nop14 Pelp1 Utp25 Rpl39l Rcl1 Nop10 Rps15a Tbl3 Nol12 Nol11 Rpp40 Wdr3 Bud23 Rps27l Dcaf13 Rplp2 Utp15 Rpl22l1 Rbm28 Rplp1 Riok3 Rpl13a Heatr1 Rpl18a Utp11 Nob1 Rpl17 Nat10 Rpl18 Ddx52 Rpl19 Utp18 Rpl10l Wdr43 Rpl11 Wdr46 Noc4l Rps3 Riok1 Rps4x Riok2 Gnl3 Ddx49 Ddx47 Thumpd1 Nip7 Tsr3 Rrp36 Nol9 Mphosph6 Rpp14 Nol6 Utp14a Mphosph10 Trmt112 Pes1 Bms1 C1d Krr1 Utp3 Utp4 Utp6 Bop1 Ebna1bp2 Wdr18 Tsr1 Ddx21 Wdr12 Csnk1e Rps27 Hsd17b10 Prorp Trub2 Nsun4 Trmt10c Rpusd4 Tfb1m Mterf4 Mterf3 Rcc1l Mrm1 Mrm2 Mrm3 Ngrn Fastkd2 GSD IV%REACTOME DATABASE ID RELEASE 96%3878781 GSD IV Gbe1 Gys2 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9638630 Attachment of bacteria to epithelial cells Upk1a Epcam REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME DATABASE ID RELEASE 96%9909620 Regulation of PD-L1(CD274) translation Cd274 Tnrc6c Ago4 Ago3 Ago2 Ago1 Tnrc6a Tnrc6b Mov10 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669935 Signaling by juxtamembrane domain KIT mutants Kit PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) Rasgrp2 Fgb Fga Rap1b Vwf Rasgrp1 Fgg Thpo Itgb3 Sos1 Crk Gp1ba Tln1 Fn1 Bcar1 Csk Itga2b Akt1 F2 Src Shc1 Ptpn1 Syk Ptk2 Rapgef4 Rapgef3 Gp9 Mpl Gp1bb Rap1a Pdpk1 Gp5 Adra2a Adra2c Apbb1ip Adra2b SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R Nras Igf2 Igf1 Igf1r Sos1 Hras EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%2682334 EPH-Ephrin signaling Ephb4 Ephb6 Myl6 Efnb1 Pak1 Efnb2 Efnb3 Efna4 Vav2 Efna5 Mmp9 Rasa1 Pak3 Pak2 Epha1 Ngef Arpc1b Actr2 Clta Arpc1a Ap2m1 Actr3 Cltc Arhgef7 Sdcbp Actg1 Actb Arpc3 Arpc2 Ap2a2 Cltb Ap2a1 Arpc5 Arpc4 Rock2 Rock1 Myh14 Myh10 Limk1 Limk2 Ap2b1 Ap2s1 Ptk2 Dnm1 Git1 Wasl Tiam1 Ephb2 Hras Rhoa Nck2 Grin2b Fyn Sdc2 Adam10 Lyn Yes1 Grin1 Myh9 Epha2 Myl12a Psen1 Itsn1 Psen2 Ncstn Myl12b Rac1 Aph1b Efna1 Efna2 Arhgef28 Kalrn Myh11 Efna3 Mmp2 Epha3 Epha4 Epha5 Epha6 Cfl1 Epha7 Epha8 Vav3 Ephb1 Ephb3 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME%R-HSA-9845323.1 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Actl6a Smarce1 Spocd1 Dnmt3l H2bc9 H2bc7 H2bc8 H2bc3 Gatad2a Gatad2b H2ab2 Mbd3 Actb H2bu2 Mta1 Mta3 Arid1a Arid1b Hist2h2aa1 Ss18 Dpf1 Dpf2 Dpf3 Ss18l1 H2bc14 Bcl7a Bcl7b H2ac20 Bcl7c Hdac2 Hdac1 Smarcb1 H2bc21 H2bc26 Rbbp4 Rbbp7 Piwil4 Smarca2 Smarca4 Chd3 Chd4 Smarcd1 H2ac12 Smarcd2 H2ac11 Dnmt3a Smarcc2 H2ac15 Smarcc1 H3c7 H2ax Smarcd3 Mta2 Hist1h2bp H2aj SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH Dlgap5 Pbx1 Plxnd1 Ptcra St3gal6 Mfng Rfng Pofut1 Psma4 Flt4 Poglut1 Jun Psma3 Mdk Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Fabp7 Psmb1 Psmb3 Gzmb Psmb2 Elane Itch Notch1 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Numb Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Lfng Cul1 Trp53 Ybx1 Smad3 H2ac20 Hdac1 St3gal4 Hdac4 Wwp2 Myc Akt1 Cntn1 Hes1 Hif1a Notch4 Ywhaz Mov10 Atp2a1 Elf3 Sirt6 H2ac12 Notch2 H2ac11 Ago4 Notch3 Ago3 Atp2a3 Ago2 Ago1 Atp2a2 B4galt1 H2ac15 H3c7 H2ax Maml1 Maml2 Hdac11 Hist1h2bp Hdac10 Rbpj H2aj Arrb2 Arrb1 Hey2 Hey1 Sel1l H2bc9 H2bc7 H2bc8 H2bc3 Mib2 Ncor2 Stat1 H2ab2 H2bu2 Mamld1 Tfdp2 Tfdp1 Ccnd1 Egfr Kat2b E2f1 E2f3 Kat2a Hist2h2aa1 Furin Tle4 Tle2 Dtx1 Tle1 Dtx2 Dlk1 Dner Rab6a H2bc14 Fcer2a Hdac2 Hdac5 Prkci Egf H2bc21 Hdac7 Tnrc6c Hdac6 H2bc26 Dtx4 Hdac9 Hdac8 Ncor1 Tnrc6a Tnrc6b Dll4 Jag2 Jag1 Cdk8 Adam10 Ep300 Tbl1x Neurl1b Adam17 Neurl1a Dll1 Mib1 Hdac3 Tbl1xr1 Psen1 Psen2 Ncstn Aph1b Heyl Hes5 Ccnc Crebbp Wwc1 Tacc3 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis Lingo1 Omg Ngf Rtn4 Ngfr Mcf2 Arhgdia Rhoa Mag DEFECTIVE GGT1 CAUSES GLUTH%REACTOME DATABASE ID RELEASE 96%5579022 Defective GGT1 causes GLUTH Ggt1 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 96%5657562 Essential fructosuria Khk BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA Hadha Echs1 Hadhb Acads Hadh DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) Slc16a1 Bsg SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) Nab1 Nab2 Ap2m1 Cdk5r1 Trib1 Arc Tph1 Cdk5 Id2 Id3 Fosl1 Egr3 Sgk1 Egr4 Dnal4 Lyl1 Ascl1 Rrad Ap2a2 Cdk5r2 F3 Ap2a1 Vgf Map2k5 Adcyap1 Ap2b1 Ap2s1 Dnm1 Dnm3 Jund Rps6ka1 Adora2a Chd4 Id4 Id1 Rest Adcyap1r1 Fos Pik3r1 Pik3r2 Fosb Mapk7 Elk1 Clta Stat3 Junb Cltc Sh3gl3 Pik3cb Tcf12 Dnm2 Sh3gl2 Shc3 Pik3ca Shc2 Shc1 Mapk1 Braf Mapk3 Crkl Ywhab Mapk12 Rap1a Rps6ka3 Mapkapk3 Rps6ka2 Mapk13 Mapkapk2 Mapk14 Rala Ralb Ppp2cb Frs2 Ppp2ca Ngf Irs1 Kidins220 Ralgds Irs2 Map2k2 Rit1 Rit2 Nras Ntrk1 Plcg1 Map2k1 Rapgef1 Sos1 Egr2 Crk Ntrk2 Hras Rhoa Mapk11 Rps6ka5 Atf2 Vrk3 Srf Ep300 Egr1 Ppp2r1b Ppp2r1a Mef2d Dusp3 Dusp4 Dusp7 Dusp6 Mef2a Ppp2r5d Mef2c NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation Fbxw10 Fbxw4 Fbxw5 Fbxw7 Fbxw9 Fbxw2 Rbx1 Ube2d3 Fbxo4 Fbxo6 Fbxo32 Dcaf7 Fbxl3 Fbxl5 Cul2 Ddb1 Cul4a Cul4b Dtl Mul1 Dpp3 Ddb2 Kbtbd7 Ubxn7 Cul3 Dcaf13 Sqstm1 Cops3 Cops6 Cops8 Cops7a Cops7b Skp2 Cdkn1a Amer1 Lrr1 Birc5 Fbxl20 Wsb1 Ccnf Keap1 Kbtbd13 Kbtbd8 Gan Fbxw8 Klhl9 Psma4 Psma3 Psma6 Klhl2 Psma5 Psma2 Spsb2 Psma1 Spsb1 Spsb4 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Cop1 Kctd7 Uchl3 Psmb5 Psmb4 Ube2m Psmb7 Senp8 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Ube2f Neurl2 Commd8 Fbxo10 Commd9 Btrc Fbxo11 Wsb2 Psma7 Fbxo17 Fem1b Psmc6 Lmo7 Tulp4 Psmc5 Fem1c Psmc2 Dcaf8 Psmc1 Dcaf4 Psmc4 Lrrc41 Dcaf5 Psmc3 Kctd6 Klhl13 Dcaf6 Ubc Pum2 Klhl11 Ccdc22 Psmd7 Hif3a Psmd6 Dda1 Ccdc8 Fbxo21 Fem1aa Psmd8 Commd4 Psmd3 Fbxo22 Commd5 Psmd2 Commd6 Psmd1 Commd7 Commd1 Adrm1 Commd2 Sem1 Commd3 Fbxo27 Cul1 Spsb3 Ankrd9 Commd10 Socs5 Socs6 Ubd Klhl25 Nae1 Wdtc1 Dcun1d5 Btbd6 Dcun1d4 Dcun1d3 Klhl21 Dcun1d2 Klhl22 Dcun1d1 Klhl20 Cul9 Fbxl8 Dcaf17 Fbxo30 Dcaf10 Fbxo31 Dcaf11 Fbxl4 Ercc8 Fbxl7 Zbtb16 Uba3 Cul5 Cul7 Fbxo41 Fbxo44 Hif1a Socs2 Klhl41 Klhl42 Cish Fbxo40 Btbd1 Fbxo2 Asb12 Asb11 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Palb2 Rnf7 Fbxo7 Fbxo9 Vhl Brca1 Fbxl12 Fbxl13 Fbxl14 Fbxl15 Fbxl16 Fbxl18 Fbxl19 Asb9 Asb8 Asb7 Asb6 Asb5 Asb4 Asb3 Asb2 Ube2d1 Cops4 Asb1 Cops2 Vcp Cops5 Cand1 Socs3 Epas1 Wdr5 Nedd8 Rbbp5 Rbbp7 Ufd1 Nploc4 Nfe2l2 Eloc POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%110362 POLB-Dependent Long Patch Base Excision Repair Adprs Polb Parp1 Apex1 Lig1 Fen1 Parg Parp2 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576892 Phase 0 - rapid depolarisation Cacnb1 Cacnb2 Cacng8 Cacng4 Scn7a Scn11a Scn3a Scn3b Scn8a Fgf14 Cacng6 Cacna1c Scn4a Fgf12 Fgf13 Scn4b Fgf11 Scn9a Scn5a Camk2g Scn1a Camk2d Scn1b Cacng7 Camk2b Camk2a Scn10a Cacna2d2 Scn2a Scn2b SUMOYLATION OF RNA BINDING PROTEINS%REACTOME%R-HSA-4570464.4 SUMOylation of RNA binding proteins Rnf2 Nop58 Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Ube2i Nup133 Nup188 Tpr Hnrnpk Nup107 Rae1 Ndc1 Nup42 Nup62 Pcgf2 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Ring1 Cbx8 Phc2 Hnrnpc Phc1 Cbx4 Cbx2 Phc3 Nup85 Bmi1 Nup37 Sec13 Nup160 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia Abcg8 Abcg5 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%1170546 Prolactin receptor signaling Jak2 Prlr Ghr Btrc Rbx1 Prl Skp1 Stat5a Cul1 Stat5b Ptpn11 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes G6pdx Mafg Taldo1 Tkt Nfe2l2 Crebbp Pgd Ep300 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells Onecut3 Nkx6-1 Onecut1 Ptf1a Pdx1 Fgf10 Hnf1b SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 96%69239 Synthesis of DNA Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Lig1 Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Orc5 Rfc1 Orc4 Rfc2 Orc6 Pold4 Orc1 Pold3 Mcm8 Orc3 Orc2 Dna2 Pole3 Pole2 Pole4 Rpa1 Rpa2 Rpa3 Pole Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Ccne1 Ccne2 Fzr1 Skp2 Gins2 Gins1 Mcm7 Gins4 Gins3 Cdk2 Mcm3 Mcm4 Ccna1 Mcm5 Ccna2 Mcm6 Cdc45 Mcm2 Cdt1 Gmnn Fen1 Cdc6 Prim2 Prim1 Pola2 Pola1 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%977068 Termination of O-glycan biosynthesis Muc1 St6galnac3 St6galnac4 St6galnac2 Muc15 St3gal4 Muc13 Muc4 Muc6 St3gal2 Muc20 St3gal1 St6gal1 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination Polr3k Polr3gl Polr2h Crcp Polr3a Polr2e Polr3d Polr2f Nfix Polr2k Ssb Polr3e Polr1c Nfia Polr3b Nfic Polr3c Polr3h Polr3f Polr1d Polr3g APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 96%140342 Apoptosis induced DNA fragmentation H1f3 H1-1 Kpna1 H1-0 Kpnb1 Casp3 Hmgb2 H1-5 Dffa H1-4 Dffb H1f2 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5685938 HDR through Single Strand Annealing (SSA) Topbp1 Rpa2 Rad17 Rbbp8 Brca1 Rpa3 Rad1 Atm Kat5 Lig1 Exo1 Abl1 Nbn Rfc5 Rad52 Ercc1 Rfc3 Ercc4 Rfc4 Rfc2 Hus1 Atrip Brip1 Dna2 Blm Rad9a Bard1 Rad9b Top3a Wrn Mre11a Rad51 Rad50 Rpa1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 96%416550 Sema4D mediated inhibition of cell attachment and migration Rac1 Arhgap35 Sema4d Rras Rnd1 Plxnb1 Rhoa Met NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654733 Negative regulation of FGFR4 signaling Ppp2cb Fgf16 Frs2 Ppp2ca Fgf15 Fgf18 Fgf2 Fgf1 Fgf4 Cbl Fgf6 Fgf9 Fgf20 Ubc Ptpn11 Fgf23 Fgfr4 Mapk1 Braf Mapk3 Spry2 Klb Ppp2r1a Mknk1 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects Ccne1 Ccne2 Tfdp2 Tfdp1 Rb1 Ccnd2 Ccnd3 Ccnd1 Cdk6 Cdk4 Cdk2 E2f1 E2f2 E2f3 Cdkn1a Cdkn1b Cdkn1c G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription Fbxo5 Hdac1 Cdc6 Rbl2 Tyms Dhfr Rbbp4 Rbl1 Tk1 Cdk1 Pcna Ccne1 Pola1 Orc1 Tfdp2 Tfdp1 E2f4 E2f5 E2f6 E2f1 Ccna1 Rrm2 Cdc45 Lin54 Lin9 Cdt1 Lin37 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation Hgfac Spint1 Hpn Spint2 Hgf Met FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9823739 Formation of the anterior neural plate Zic2 Pou3f1 Sox2 Pax6 Zeb2 Sox1 Znf521 Pou5f1 Gbx2 Otx2 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%73884 Base Excision Repair Rpa2 Polb Apex1 Xrcc1 Lig3 H2bc9 Rpa3 H2bc7 H2bc8 Tinf2 H2bc3 Parp2 Pole Parp1 H2ab2 H3c8 H2bu2 Acd Mpg Terf2ip Terf2 Terf1 Hist2h2aa1 Fen1 Pot1 H2bc14 H2ac20 Parg Adprs H2bc21 H2bc26 Lig1 Rfc5 Pold2 Pold1 Neil2 Rfc3 Neil3 Nthl1 Pcna Ogg1 Rfc4 H2ac12 Pnkp Neil1 H2ac11 Rfc1 Mbd4 Rfc2 Smug1 Pold4 Pold3 H2ac15 H2ax Pole3 Pole2 Pole4 Hist1h2bp H2aj Rpa1 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 96%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 Prelp Omd Lum Ogn Fmod Kera RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates Rbbp8 Brca2 Brca1 Xrcc3 Rad51ap1 Xrcc2 Atm Kat5 Exo1 Eme1 Mus81 Nbn Gen1 Fignl1 Brip1 Dna2 Rad51c Rad51d Blm Rad51b Bard1 Top3a Slx4 Wrn Mre11a Spidr Palb2 Sem1 Rad51 Rad50 Firrm FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids Cyp2b10 Cyp4f14 Cyp2a5 Cyp4a32 Cyp4f15 Cyp2d22 Cyp4f39 Cyp4f17 Cyp4a12b Cyp2j6 Cyp4f3 Cyp2f2 Cyp4f40 Cyp4b1 Adh7 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function Opn1mw VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels Kcna6 Kcna5 Kcna4 Kcna3 Kcna2 Kcna10 Kcna1 Kcnf1 Kcng4 Kcng3 Kcng2 Kcng1 Kcnh1 Kcnd3 Kcnd2 Kcnd1 Kcnv2 Kcnv1 Kcnb2 Kcnb1 Kcnab1 Kcns3 Kcnab2 Kcns2 Kcns1 Kcnab3 Kcnc4 Kcnc3 Kcnc2 Kcnc1 Kcnq4 Kcnq3 Kcnq2 Kcnh8 Kcnh7 Kcnh6 Kcnh5 Kcnh4 Kcnh3 Kcnh2 Kcnq5 Kcnq1 Kcna7 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME%R-HSA-9955542.1 CPS1 variants cause CPS1 deficiency Cps1 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME DATABASE ID RELEASE 96%9818032 NFE2L2 regulating MDR associated enzymes Mafk Abcg2 Abcf2 Nfe2l2 Crebbp Abcc1 Ep300 Abcc3 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly Hsp90aa1 Ipo5 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins Fgb Fga Src Rap1b Vwf Fgg Itgb3 Sos1 Tln1 Fn1 Itga2b Ptk2 Rap1a Apbb1ip INTERLEUKIN-9 SIGNALING%REACTOME%R-HSA-8985947.8 Interleukin-9 signaling Il9 Stat3 Il9r Jak1 Stat1 Il2rg Jak3 Stat5a Stat5b GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia G6pc1 DEPURINATION%REACTOME DATABASE ID RELEASE 96%73927 Depurination H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Tinf2 H2bc3 H2bc21 H2bc26 H2ab2 H3c8 Neil3 H2bu2 Ogg1 H2ac12 H2ac11 Acd Mpg H2ac15 H2ax Terf2ip Terf2 Hist1h2bp Terf1 Hist2h2aa1 H2aj Pot1 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 96%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 Plk1 Cdk1 Nek9 Ccnb2 Nek6 Nek7 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 96%68689 CDC6 association with the ORC:origin complex Cdc6 Orc5 Orc4 Orc6 Orc1 Mcm8 Orc3 Orc2 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 96%72200 mRNA Editing: C to U Conversion Apobec4 Apobec2 Apobec3 A1cf Apobec1 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655302 Signaling by FGFR1 in disease Frs2 Fgf2 Fgf1 Bcr Nras Fgf4 Gab1 Plcg1 Fgf6 Bag4 Sos1 Stat5a Fgf9 Cep43 Stat5b Hras Fgf20 Gab2 Fgf23 Fgfr1 Stat3 Erlin2 Stat1 Myo18a Cux1 Fgfr1op2 Cpsf6 Zmym2 Pik3ca Pik3r1 Trim24 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 96%9793528 Ciprofloxacin ADME Abcg2 Alb Slco1a4 Slc22a1 Slc22a8 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 96%156587 Amino Acid conjugation Glyatl3 Acsm2 Acsm4 Acsm5 Glyat Acsm1 SDK INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373756 SDK interactions Sdk1 Sdk2 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism Pdp1 Fahd1 Pdp2 Ranbp9 Pdpr Gid4 Maea Ldha Ldhb Gid8 Pcx Ldhc Armc8 Me3 Dlat Me2 Rmnd5a Rmnd5b Sirt4 Gstz1 Dld Ubc Pdhx Ldhal6b Glo1 Gpt Wdr26 Pdha1 Vdac1 Pdha2 Mpc1 Me1 Mpc2 Pdk4 Nek1 Pdk3 Mkln1 Pdk2 Pdk1 Pdhb BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%1307965 betaKlotho-mediated ligand binding Fgf15 Fgfr4 Klb NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 96%112313 Neurotransmitter uptake and metabolism In glial cells Glul Slc1a3 Slc1a2 Slc38a1 REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 96%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation Tbk1 Traf3 Ticam1 Tlr3 Ikbke Tank Optn Ubc STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-HSA-1834941.5 STING mediated induction of host immune responses Trim21 Stat6 Cgas Sting1 Ddx41 Prkdc Trex1 Xrcc6 Xrcc5 Tbk1 Nlrc3 Irf3 Nlrp4e Dtx4 Mre11a DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants Pdgfra VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%5620916 VxPx cargo-targeting to cilium Exoc7 Exoc8 Gbf1 Rab11fip3 Arf4 Rab8a Rab3ip Pkd2 Pkd1 Rab11a Rho Exoc3 Asap1 Exoc4 Exoc5 Cnga4 Exoc6 Cnga2 Exoc1 Exoc2 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 96%2219530 Constitutive Signaling by Aberrant PI3K in Cancer Rac2 Tgfa Trat1 Pdgfrb Ereg Pik3ap1 Hbegf Ntrk3 Btc Epgn Cd86 Cd80 Flt3l Src Nrg1 Pik3cg Pik3cb Pik3cd Hgf Egfr Met Pik3ca Flt3 Esr2 Nrg2 Klb Nrg4 Fgf16 Frs2 Nrg3 Fgf15 Irs1 Fgf18 Irs2 Lck Fgf2 Bdnf Fgf1 Fgf4 Gab1 Fgf10 Esr1 Fgf3 Fgf6 Ntf4 Fgf7 Ntrk2 Fgf9 Fgf20 Ntf3 Gab2 Ptpn11 Fgf23 Fyn Egf Fgfr4 Fgf22 Areg Strn Kit Rhog Pdgfb Pdgfra Cd28 Erbb2 Rac1 Vav1 Pik3r5 Pik3r6 Cd19 Pik3r1 Pik3r2 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT Socs6 Jak2 Grb10 Lck Mmp9 Nras Prkca Ptpn6 Sos1 Stat5a Grap2 Stat5b Hras Ptpn11 Gab2 Fyn Stat3 Ptpru Stat1 Cma1 Grap Sh2b2 Sh2b3 Socs1 Fer Tec Kit Fes Lyn Yes1 Grb7 Cbl Pik3ca Chek1 Rac1 Vav1 Pik3r1 Pik3r2 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints Ywhae Cdc25c Cdc25a Rbx1 Trp53 Mdc1 Orc5 Orc4 Orc6 Orc1 Mcm8 Orc3 Orc2 Sfn Cdkn2a H3c8 Ccne1 Ccne2 Mdm2 Cdk2 Mdm4 Ccna1 Ccna2 Cdkn1a Cdkn1b Clasp1 Clasp2 Pafah1b1 Dbf4 Nup37 Zw10 Nup160 Mcm10 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Kif2b Kif2c Dync1li2 Pmf1 Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Clspn Rps27 Trp53bp1 Rcc2 Abraxas1 Brcc3 Kntc1 Rnf168 Nsd2 Ppp2r1b Ppp2r1a Babam1 Babam2 Uimc1 Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Nuf2 Ccnb2 Nup85 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Psma4 Cenpo Cenpn Psma3 Cenpm Psma6 Mis12 Psma5 Nup133 Psma2 Cenpl Psma1 Zwilch Cenpk Cenpi Cenph Psmd12 Phf20 Psmd11 Pcbp4 Cenpf Psmd14 Chek2 Cenpe Psmd13 Zfp385a Skp1 Cop1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Gtse1 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Ube2n Ube2v2 Pias4 Ywhah Kat5 Exo1 Nbn Rfc5 Ywhaz Rfc3 Rfc4 Rfc2 Hus1 Atrip Brip1 Dna2 H2ax Blm Chek1 Hist1h2bp Rad9a Bard1 Rad9b Top3a Wrn Mre11a Herc2 Rad50 Rpa1 Topbp1 Rpa2 Rad17 Rbbp8 Brca1 H2bc9 Rpa3 H2bc7 Plk3 H2bc8 Rad1 Cdc7 Atm H2bc3 Plk1 Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdk1 Cdc27 Ube2d1 Cdc16 Anapc16 Pkmyt1 Ube2e1 Cdc23 Anapc15 H2bu2 Mcm7 Mcm3 Mcm4 Mcm5 Mcm6 Cdc45 Mcm2 Ywhab Wee1 Ywhag Mapk14 Gsk3b Csnk1e Csnk1a1 Nek11 H2bc14 Mapk11 Cdc6 H2bc21 H2bc26 Xpo1 INITIATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769735.1 Initiation of coagulation cascade F2 F3 Vwf F5 F7 F8 F9 Sdc1 Gpc1 Pros1 Gpc3 Gpc2 Agrn Hspg2 Gpc5 Sdc4 Sdc3 Gpc4 Sdc2 Gpc6 F10 Serpinc1 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) Glb1 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D Gns GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) Cd274 Gsk3b Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Nek2 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Cops5 Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 96%190873 Gap junction degradation Clta Cltb Ap2m1 Gja1 Cltc Myo6 Dab2 Dnm1 Dnm2 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation Fga Apoe H2bc9 H2bc7 H2bc8 App Usp9x H2bc3 Gga2 Prkn Gga1 H2ab2 Prl Gga3 Bace1 H2bu2 Mfge8 Tspan5 Odam Itm2b Ttr B2m Sncaip Tspan33 Calb1 Apoa4 Apcs H2az1 Ltf Tspan14 Tspan15 Tgfbi Cst3 Nat8 Ubc Sorl1 Iapp Hist2h2aa1 Furin Gsn H2bc14 Nppa H2ac20 H2bc21 H2bc26 Hspg2 Snca Adam10 H2ac12 H2ac11 Saa3 H2ac15 H3c7 H2ax Ncstn Siah1a Ube2l6 Aph1b Hist1h2bp Ins2 Apoa1 Siah2 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) Gys1 Gyg1 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling Ranbp10 Muc20 Ranbp9 Nras Sos1 Hras Hgf Met TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Pcna Trp53 Gadd45a Tfdp2 Tfdp1 Prmt1 E2f4 Rbl2 Bax Sfn Rbl1 Aurka Zfp385a Cdk1 Carm1 Cdc25c Ep300 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 96%5685939 HDR through MMEJ (alt-NHEJ) Rbbp8 Parp1 Brca2 Xrcc1 Lig3 Polq Fen1 Mre11a Nbn Rad50 Rad52 Parp2 MMR%REACTOME%R-HSA-5358508.3 MMR Pcna Rpa2 Pold4 Pold3 Rpa3 Lig1 Exo1 Msh6 Msh2 Msh3 Pold2 Pms2 Pold1 Mlh1 Rpa1 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390651 Dopamine receptors Drd1 Drd2 Drd3 Drd4 Drd5 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000497 Scavenging by Class H Receptors Stab1 Stab2 Sparc Apob DEFENSINS%REACTOME DATABASE ID RELEASE 96%1461973 Defensins Cd4 Prss2 Ccr6 Art1 Defb47 Defb14 Ccr2 Defb36 Tlr1 Defb25 Defb15 Tlr2 Defb18 Defb29 Defb19 Defb23 Defb12 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Sox2 Pou5f1 OPSINS%REACTOME DATABASE ID RELEASE 96%419771 Opsins Opn4 Opn1sw Opn3 Rho Opn5 Rrh Rgr Opn1mw DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) Slc22a12 PEPTIDE HORMONE METABOLISM%REACTOME%R-HSA-2980736.5 Peptide hormone metabolism Gata4 Bche Ffar4 Ffar1 Ace2 Inha Cma1 Exoc3 Exoc4 Inhba Exoc5 Ctsd Exoc6 Exoc1 Exoc2 Myo5a Sec11c Sec11a Exoc7 Exoc8 Lhb Ctsz Ctsg Ctnnb1 Ucn Fshb Ero1b Ces1d Crhr2 Cpa3 Kif5c Mme Kif5b Isl1 Gip Enpep Mboat4 Atp6ap2 P4hb Gzmf Dpp4 Pla2g7 Slc30a5 Gnat3 Ace Cltrn Cdx2 Rab27a Slc30a8 Anpep Pcsk1 Pcsk2 Pax6 Gpr119 Igf1 Cpe Inhbb Cpb1 Inhbc Myrip Inhbe Lep Vamp2 Tcf7l2 Stx1a Grp Pomc Gcg Agt Spcs3 Spcs1 Spcs2 Ache Gnb1 Klf4 Gnb3 Ins2 Cga Cpb2 Tshb Gng13 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME%R-HSA-165054.4 Rev-mediated nuclear export of HIV RNA Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Ran Xpo1 Nup85 Rcc1 Ranbp1 Nup37 Sec13 Nup160 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 96%422085 Synthesis, secretion, and deacylation of Ghrelin Pla2g7 Bche Pcsk1 Ucn Igf1 Gcg Spcs3 Spcs1 Lep Spcs2 Ache Crhr2 Klf4 Ins2 Mboat4 Sec11c Sec11a SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU Furin GSD IB%REACTOME%R-HSA-3229133.4 GSD Ib Slc37a4 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD Gclc Gclm TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades Tlr4 Ctsk Ctsl Irf7 App Ikbkb Jun Plcg2 Birc3 Birc2 Peli1 Traf3 Ikbkg Map3k7 Ticam2 Traf2 Ticam1 Cd14 Btk Ikbke Tank Optn Nfkb1 Socs1 Skp1 Fadd Fbxw11 Rela Ripk3 Btrc Casp8 Ripk1 Ube2d3 Ubc Gsdme Gsdmd Nfkbib Irak1 Nfkbia Cul1 Traf6 Dnm1 Ube2n Chuk Dnm3 Ube2v1 Trp53 Tab3 Sigirr Tab2 Tab1 S100a1 Irak3 Cd36 Tirap Rps6ka1 Tifa Alpk1 Nfkb2 Fos Fgb Fga Mapk9 Mapk7 Fgg Mapk8 S100a9 Elk1 S100a8 Tlr1 Tlr6 Tlr2 Map3k8 Ube2d1 Tasl Rbsn Eea1 Irf5 Dnm2 Mapk1 Mapk3 Rps6ka3 Mapkapk3 Rps6ka2 Mapkapk2 Map2k7 Mapk14 Itgam Map2k6 Ppp2cb Ppp2ca Itgb2 Map2k4 Slc15a4 Map2k3 Mapk10 Pik3c3 Map2k1 Mapk11 Cd180 Ptpn11 Ly86 Ripk2 Lbp Tbk1 Myd88 Bpi Rps6ka5 Irf3 Tlr9 Pik3r4 Nkiras1 Atf2 Nkiras2 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Ppp2r1a Peli2 Peli3 Tlr5 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Ctsb Ctss Mef2a Unc93b1 Usp14 Lgmn Ptpn4 Usp18 Hsp90b1 Tlr8 Tlr7 Tlr3 Ppp2r5d Ly96 Mef2c Apob CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856825 Cargo recognition for clathrin-mediated endocytosis Tacr1 Cd3g Arrb1 Tor1b Necap2 Cd3d Necap1 Scarb2 Sgip1 Itsn2 Dab2 Agfg1 Grk3 Snap91 Syt9 Tgfa Syt8 Aak1 Ereg Clta Hbegf Ap2m1 Picalm Cltc Ldlrap1 Btc Epgn Syt11 Slc2a8 Ubqln2 Epn2 Ubqln1 Dvl2 Cops4 Epn1 Cops3 Cops6 Cops2 Il7r Avpr2 Lrp2 Stam2 Ap2a2 Ston2 Cops8 Sh3gl3 Eps15l1 Cltb Ap2a1 Sh3kbp1 Avp Cops7a Vamp7 Stam Cops7b Ldlr Vamp8 Eps15 Reps2 Cbl M6pr Hgs Sh3gl1 Sh3gl2 Egfr Ap2b1 Ubc Cops5 Wnt5a Tf Ap2s1 Igf2r Chrm2 Tfrc Vamp4 Adrb2 Agtr1a Cd4 Nedd8 Egf Areg Syt2 Syt1 Vamp2 Cftr Grk2 Slc18a3 Fzd4 Vamp3 Itsn1 Fcho1 Fcho2 D130043K22Rik Arrb2 Tor1a Apob ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 96%1169092 Activation of RAS in B cells Rasgrp3 Nras Rasgrp1 Hras PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling Psma4 Jun Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rela Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 H2ac20 H2-Eb1 Prkaa1 Prkaa2 Myc Erlin2 Erlin1 Atf3 Jund Rpn2 Rpn1 Hif1a Tcf7l1 Tcf7l2 Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 Ezh2 H2ax B3gnt3 Csnk2a2 Tead4 Suz12 Nfkb2 Ash2l Hist1h2bp Jak1 Fos H2aj Os9 Yap1 Cd3g Cd3e Cd3d Sel1l Fosb Magt1 Brd4 H2bc9 H2bc7 Cul3 H2bc8 H2bc3 Mib2 Tead3 Tead2 Tead1 Stat3 Tmem258 Stat1 H2ab2 Rnf185 Mycn Derl3 Nek2 Derl2 Derl1 H2bu2 Stt3a Stt3b Spop Ctnnb1 Vcp Tcf7 Ostc Prkag3 Ccnd1 Prkag1 Prkag2 Cdk4 Cops5 Wwtr1 Tusc3 Kmt2c Hist2h2aa1 Erlec1 Dad1 Ywhag Epas1 Dpy30 Wdr5 Ddost Csnk2b Eed Cd274 Gsk3b Lck Irf1 Lef1 H2bc14 Ptpn6 Pdcd1 Rnf5 Cd4 Ptpn11 Csk H2bc21 Tnrc6c H2bc26 Rbbp5 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Pdcd1lg2 Prkab2 Ep300 Prkab1 Nfe2l2 Crebbp MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation Tfb2m Tfam Polrmt ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME DATABASE ID RELEASE 96%5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis Pbx1 H2bc9 H2bc7 H2bc8 Jun H2bc3 Pcgf2 H2ab2 Kdm6a Yy1 Rarb H2bu2 Ncoa3 Polr2c Polr2d Polr2a Rarg Polr2b Polr2g Kmt2c Polr2h Hist2h2aa1 Polr2e Polr2f Polr2k Polr2i Polr2j Dpy30 Cnot6 Wdr5 Eed Cnot9 Kmt2d Pax6 H2bc14 H2ac20 Egr2 Rxra Rara H2bc21 H2bc26 Pagr1a Rbbp5 Hoxc4 Rbbp4 Ctcf Ncor1 Rbbp7 Hoxd1 Pias2 Hoxb3 Hoxa2 Hoxb1 Hoxb2 Paxip1 Ep300 Hoxa3 Hoxa1 Ajuba Hoxa4 Pknox1 H2ac12 Mafb H2ac11 Zfp335 Meis1 Hdac3 Hoxd3 Hoxd4 H2ac15 H3c7 Ezh2 H2ax Hoxb4 Suz12 Ncoa6 Ash2l Hist1h2bp H2aj Crebbp NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Npm1 Ran Nup85 Rcc1 Kpnb1 Nup37 Sec13 Nup160 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels Kcnj12 Kcnj2 Kcnj14 Kcnj4 PI METABOLISM%REACTOME DATABASE ID RELEASE 96%1483255 PI Metabolism Pi4kb Pip4p1 Pnpla6 Pip4k2b Enpp6 Inpp5k Mtm1 Pip4k2a Pnpla7 Pik3c2b Bmx Pik3c2g Pitpnb Fig4 Vac14 Mtmr3 Mtmr1 Tnfaip8 Mtmr7 Pik3c2a Mtmr6 Pip5k1b Mtmr9 Pip5k1a Synj2 Rab4a Arf1 Rab5a Pip5k1c Pik3cg Pik3cb Mtmr4 Pik3cd Pik3ca Ocrl Sacm1l Pi4k2b Mtmr2 Pi4ka Sbf1 Pik3c3 Ptpn13 Pik3r4 Inpp5e Inpp5d Synj1 Pten Arf3 Pikfyve Inppl1 Gde1 Pi4k2a Sbf2 Plekha8 Plekha6 Plekha5 Inpp4a Inpp4b Plekha3 Plekha2 Plekha1 Tpte Tnfaip8l2 Mtmr10 Tnfaip8l3 Gdpd5 Tnfaip8l1 Pik3r5 Mtmr14 Pik3r6 Gdpd3 Pik3r1 Rab14 Mtmr12 Pik3r2 Gdpd1 Rufy1 Inpp5f THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome Nlrc4 Casp1 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 Epo Jak2 Epor Irs2 Stat5a Stat5b Lyn SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855167 Synthesis of pyrophosphates in the cytosol Ippk Ppip5k1 Ppip5k2 Itpk1 Nudt4 Nudt3 Ip6k1 Nudt11 Ip6k3 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 96%9818035 NFE2L2 regulating ER-stress associated genes Mafk Nfe2l2 Crebbp Ep300 Atf4 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 96%201451 Signaling by BMP Smad1 Bmp2 Acvr2b Cer1 Smad4 Smad6 Smad7 Inha Tgfbr3 Acvr2a Inhba Smurf2 Smurf1 Ube2d1 Grem2 Bmp10 Acvrl1 Ski Amhr2 Amh Zfyve16 Nog Gdf2 Bmpr1a Bmpr1b Bmpr2 Smad9 Smad5 Fstl1 Ube2d3 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 96%174403 Glutathione synthesis and recycling Cndp2 Gclc Gclm Gss Oplah Chac1 Chac2 Ggt7 Ggt1 Ggt5 Ggt6 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System Dlg1 Dlg3 Grik5 Dlg4 Grik2 Grik1 Grik4 Grik3 Ncald Prkx Prkacb Slc5a7 Flot2 Flot1 Ap2a1 Adcy3 Adcy4 Adcy1 Stxbp1 Adcy2 Homer1 Adcy7 Homer2 Adcy8 Begain Adcy5 Homer3 Adcy6 Kcnq4 Ptprs Ptprf Kcnq3 Adcy9 Sipa1l1 Kcnq2 Dlgap1 Apba2 Apba3 Dlgap4 Dlgap3 Il1rapl1 Gnai2 Il1rapl2 Gnai1 Nrxn1 Gnai3 Nrxn2 Ppfibp2 Ppfibp1 Prkar1b Epb41l2 Epb41l3 Epb41l5 Lrfn2 Lrfn3 Lrfn4 Gnat3 Prkar2b Lrrc4b Syt7 Shank1 Shank3 Syt12 Pdlim5 Gng10 Epb41 Slitrk6 Slitrk4 Slitrk1 Slitrk2 Lrrtm1 Lrrtm2 Akap5 Lrrtm3 Nlgn2 Nlgn1 Kcnmb1 Nlgn3 Kcnma1 Gng3 Kcnn2 Gng2 Gng4 Gng7 Gng8 Prkar2a Gngt1 Gngt2 Aldh5a1 Slc18a2 Slc18a3 Slc6a11 Gjd2 Slc6a13 Gjc1 Abat Panx2 Camk2g Unc13b Panx1 Slc22a2 Camk2d Slc22a1 Glul Camk2b Slc6a1 Slc6a4 Camk2a Ache Syn3 Gnb2 Syn2 Syn1 Gnb1 Cacna2d1 Gnb4 Cacna2d3 Gnb3 Cacna2d2 Gnb5 Gng11 Ppfia2 Ppfia4 Gng12 Ppfia1 Gng13 Cacnb3 Cacnb4 Slc32a1 Cacnb1 Prkaca Cacnb2 Cacng8 Bche Cacng4 Cacna1e Kcnj11 Cacng2 Abcc9 Cacna1a Cacng3 Cacna1b Naaa Camkk1 Camkk2 Chat Grip2 Rab3a Nsf Dnajc5 Gria4 Cplx1 Gria3 Tomt Kcnj3 Arl6ip5 Prkcg Gad1 Gad2 Kcnj2 Gria1 Cask Arhgef9 Gnal Gabrg2 Gabrg3 Lin7a Grm1 Lin7b Grm5 Lin7c Grin3b Rasgrf1 Rasgrf2 Pick1 Gabra4 Gabra3 Gabra6 Gabra5 Gabbr1 Gabra2 Gabbr2 Gabra1 Kif17 Glra3 Glra2 Glra1 Nrg1 Rps6ka6 Tspan7 Kcnj9 Kcnj6 Kcnj5 Hspa8 Mdm2 Kcnj4 Glrb Grip1 Gabrr1 Gabrr3 Gabrr2 Apba1 Nrgn Gabrq Kcnj10 Gabrb1 Comt Gabrb3 Rps6ka3 Gabrb2 Rps6ka2 Kcnj12 Htr3b Htr3a Kcnj15 Kcnj16 Syt10 Grin2b Abcc8 Kcnj8 Syt9 Aldh2 Slc1a1 Slc1a3 Prkcb Slc1a2 Kcnk1 Kcnk7 Kcnk6 Slc38a2 Slc1a7 Slc1a6 Slc38a1 Slc6a12 Plcb3 Plcb2 Plcb1 Prkca Dbnl Prkaa1 Prkaa2 Maoa Prkar1a Rps6ka1 Grin2a Camk4 Camk1 Dlg2 Actn2 Ppm1f Nefl Ppm1e Grin1 Grin2d Grin2c Gls Rac1 Ntrk3 Myo6 Chrnd Chrne Src Chrng Chrna3 Chrnb4 Chrna2 Chrnb3 Chrnb2 Prkag3 Chrna1 Chrna6 Chrna5 Prkag1 Chrna4 Prkag2 Chrna9 Mapk1 Mapk3 Kcnh8 Kcnh7 Kcnh6 Kcnh5 Kcnh4 Pdpk1 Kcnh3 Kcnh2 Kcnq5 Kcnq1 Kcna7 Kcna6 Kcnmb2 Git1 Kcna5 Kcna4 Kcna3 Gria2 Kcna2 Kcna10 Sharpin Kcna1 Nras Kcnmb4 Kcnj1 Kcnf1 Kcng4 Kcng3 Hras Kcng2 Kcng1 Kcnh1 Kcnd3 Slitrk5 Kcnd2 Slitrk3 Kcnd1 Kcnn4 Kcnn3 Kcnk13 Syt2 Kcnn1 Snap25 Kcnk10 Kcnk16 Kcnv2 Syt1 Kcnk18 Kcnv1 Vamp2 Hcn3 Prkab2 Stx1a Hcn4 Prkab1 Kcnb2 Kcnb1 Kcnk4 Kcnk3 Kcnk2 Kcnab1 Kcns3 Kcnab2 Kcns2 Kcns1 Kcnab3 Kcnc4 Kcnc3 Kcnc2 Kcnk9 Kcnc1 Slc6a3 Kcnj14 Hcn1 Gls2 Hcn2 Rtn3 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose Plin1 Nr1h2 Nr1h3 Rxrb Rxra STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 Cyp8b1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives Alox12 Aloxe3 Gpx4 Alox12b Alox15 Gpx2 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73772 RNA Polymerase I Promoter Escape Gtf2h3 Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 H2bc3 H2bc21 H2bc26 H2ab2 Polr1c Polr1d H2bu2 H2ac12 H2ac11 Rrn3 H2ac15 Tbp H3c7 H2ax Polr1b Polr1a Polr1g Polr1e Polr1h Hist1h2bp Taf1d Polr2h Hist2h2aa1 Taf1a Polr2e Taf1c Polr2f Taf1b Polr2k H2aj Mnat1 Cbx3 Ubtf Gtf2h2 Gtf2h1 Gtf2h4 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696264 RND3 GTPase cycle Arhgap35 Ptpn13 Ktn1 Muc13 Picalm Tmod3 Rnd3 Txnl1 Ckb Sema4f Rbmx Nisch Kctd13 Tnfaip1 Ckap4 Ddx4 Flot2 Plekhg5 Lemd3 Vangl2 Dsp Rock1 Depdc1b Wdr6 Dsg1a Epha2 Scrib Ccdc88a Arhgap5 Fam83b Cav1 Ubxn11 Cpd Arhgap21 Dlg5 Vangl1 Ankrd26 Pkp4 Pik3r1 Pik3r2 Rasal2 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME DATABASE ID RELEASE 96%9665245 Resistance of ERBB2 KD mutants to tesevatinib Erbb2 Cdc37 Erbin Hsp90aa1 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 96%9036866 Expression and Processing of Neurotrophins Ngf Furin Pcsk5 Pcsk6 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 96%444473 Formyl peptide receptors bind formyl peptides and many other ligands Fpr1 Saa3 Anxa1 Fpr2 App Hebp1 Fpr-s1 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation Prkaa2 Ppargc1a Mapk12 Prkag3 Prkab2 Mapk14 Prkab1 Prkag1 Mapk11 Prkag2 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 96%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Brca1 Mapk8 H2bc9 H2bc7 H2bc8 Atm H2bc3 Chek2 H3c8 Kdm4b H2bu2 Ubc Ube2n Ube2v2 Trp53 H2bc14 Pias4 Ube2i H2bc21 H2bc26 Kat5 Abl1 Trp53bp1 Abraxas1 Nbn Brcc3 Rnf168 Nsd2 Baz1b Babam1 Babam2 Uimc1 Mdc1 Bap1 Ppp5c Apbb1 Kdm4a Smarca5 H2ax Eya2 Eya1 Eya4 Eya3 Ubxn1 Hist1h2bp Bard1 Mre11a Herc2 Rad50 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME%R-HSA-9865125.1 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD Bckdhb Bckdha Dbt LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME%R-HSA-9944971.2 Loss of Function of KMT2D in Kabuki Syndrome Ash2l Kmt2d Rbbp5 Dpy30 Wdr5 STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation Flt3l Flt3 Stat5a Stat5b Ptpn11 Gab2 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 96%453276 Regulation of mitotic cell cycle Fbxo5 Psma4 Psma3 Psma6 Psma5 Plk1 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdk1 Cdc27 Skp1 Ube2d1 Psmb5 Cdc16 Nek2 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Psmb2 Fzr1 Btrc Skp2 Psma7 Psmc6 Rb1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Cdk2 Ccna1 Psmd7 Ccna2 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Cdc20 Mad2l1 Bub1b Aurka Cdc14a Pttg1 Aurkb Bub3 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Cpsf4 Pom121 Nup205 Nup133 Nup188 Eif4e Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Slbp Sympk Nup210 Nup155 Nup153 Alyref Nxf1 Cpsf1 Cpsf2 Cpsf3 Wdr33 Fip1l1 Nup85 Ncbp2 Ncbp1 Nup37 Sec13 Nup160 SIGNALING BY INTERLEUKINS%REACTOME%R-HSA-449147.13 Signaling by Interleukins Pdcd4 Pitpna Il12rb1 Il12rb2 Il27 Ppia Il27ra Crlf1 Cnn2 Mmp9 Jak3 Il3ra Il2rb Tyk2 Csf2rb2 Csf2ra Il5 Blnk Il5ra App Jun Il18 Peli1 Sod2 Traf2 S1pr1 Fasl Stat2 Il1r1 Foxo3 Lmnb1 Ctsg Rbx1 Casp8 Casp1 Gsdmd Il1a Il1b Syk P4hb Sigirr Il18bp Ptpn7 Ptpn9 Ptpn2 Ptpn5 Il4 Ptpn18 Il18r1 Il13 Il18rap Hspa9 Ptpn23 Ptpn20 Ptpn13 Ptpn14 Brwd1 Irak3 Tslp Cd36 Crlf2 Il7 Rag2 Rag1 Il2rg Inpp5d Inppl1 Sdc1 Mtap Prkaca Ccl12 Mapk9 Mapk7 Mapk8 Il34 Ptprz1 Il16 Prtn3 Txlna Ifnlr1 Stx3 Il6 Ccnd1 Cdkn1a Alox15 Rps6ka3 Il6st Rps6ka2 Itgax Map2k7 Itgam Map2k6 Ppp2cb Ppp2ca Itgb2 Map2k4 Map2k3 Mapk10 Irf4 Bcl2 Ripk2 Myd88 Bcl2l1 Nkiras1 Nkiras2 Icam1 Lrrc14 Vrk3 Ikbip Ppp2r1b Peli2 Ppp2r1a Peli3 Tnip2 Saa3 Nod2 Nod1 Birc5 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Alox5 Usp18 Ptgs2 Taldo1 Ppp2r5d Mmp2 Vcam1 Casp3 Socs5 Zeb1 Myc Maoa Akt1 Hif1a Lyn Yes1 Fpr1 Il9 Il9r H3c7 Il10 Tifa Alpk1 Nfkb2 Ccr5 Jak1 Fos Vav1 Pik3r1 Pik3r2 Ccl11 Gata3 Ccl22 Ccl20 Pak2 Ccl5 Ccl4 Ccl3 Stat3 Junb Stat1 Map3k8 Oprd1 Tec Cd86 Cd80 Ccr1 Pik3cb Pik3cd Ca1 Pik3ca Ccr2 Socs3 Lck Csf2 Ptpn6 Csf1r Cd4 Ptpn11 Fyn Cxcl10 Lbp Rps6ka5 Bcl6 Il2ra Cxcl1 Cxcl3 Itgb1 Ptpn4 Stx4 Capza1 Anxa1 Ptpn12 Stat5a Stat5b Pim1 Grb2 Timp1 Pou2f1 Vegfa Tcp1 Lifr Muc1 Anxa2 Il1rapl1 Irak1 Trp53 Ifng Msn Sos2 Il17rb Il17re Cntf Cntfr Il1f10 Clcf1 Ctf1 Fscn1 Ptafr Map3k3 Il36rn Ndn Mcl1 Mmp1a Twist1 Il4ra Il15ra Il1rl2 Il1rl1 Il21r Il22b Il36b Il36a Il20rb Il20ra Il31ra Tollip Il36g Il11 Il15 Il19 Hsp90aa1 Il22ra2 Osmr Rhou Il33 Il21 Il20 Il25 Il24 Osm Il17c Il22ra1 Batf Tgfb1 Il13ra1 Il13ra2 Ptk2b Ifnl3 Elk1 Sqstm1 Mmp3 Arf1 Canx Vamp7 Hspa8 Gsto1 Rorc Irs1 Irs2 Fgf2 Il12b Il10rb Il12a Il10ra Tnf Tnfrsf1b Tnfrsf1a Lif Fcer2a Il1r2 Il1rn Gab2 Csf3 Stxbp2 Smarca4 Csf3r Il6ra Sox2 Hsp90b1 Col1a2 Cfl1 F13a1 Stat6 Psma4 Ikbkb Psma3 Psma6 Foxo1 Fn1 Psma5 Psma2 Lama5 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Socs1 Skp1 Psmb5 Psmb4 Psmb7 Il7r Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Btrc Psma7 Psmc6 Psmc5 Psmc2 Psme2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Nfkbib Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Cul1 Traf6 Ube2n Chuk Oprm1 Ube2v1 Il2 Tab3 Tab2 Tab1 Rora Smad3 Rps6ka1 Csf1 Ywhaz Nos2 Socs2 Pomc Cish Il17rc Il17ra Hnrnpa2b1 Jak2 Rap1b Hnrnpf Vim Cbl Hgf Shc1 Mapk1 Snrpa1 Mapk3 Crkl Mapkapk3 Mapkapk2 Mapk14 Rala Map2k1 Rapgef1 Sos1 Crk Mapk11 Lcn2 Tbk1 Snap25 Atf2 Vamp2 Stx1a Cebpd Hmox1 Il17f Il17a Bola2 Hck Stat4 Il23r Serpinb2 Mef2c Aip Mif Hnrnpdl Lcp1 Ebi3 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 96%4641258 Degradation of DVL Hecw1 Psma4 Klhl12 Cul3 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Dvl1 Dvl2 Dvl3 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%177243 Interactions of Rev with host cellular proteins Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Npm1 Ran Xpo1 Nup85 Rcc1 Ranbp1 Kpnb1 Nup37 Sec13 Nup160 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-HSA-3134973.3 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Irf3 Ctnnb1 Crebbp Ep300 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9012999 RHO GTPase cycle Plxnd1 Wipf3 Wipf2 Wipf1 Lmnb1 Flot2 Flot1 Cyfip2 Dock7 Senp1 Samm50 Was Wasf3 Mtx1 Wasl Ptpn13 Wwp2 Cdc42bpa Cdc42bpb Rhoj Slc4a7 Fnbp1 Dock8 Fnbp1l Cpne8 Scrib Fmnl3 Nipsnap2 Rasal2 Cul3 Arhgef9 Rasgrf2 Pard6b Abcd3 Farp2 Tiam1 Frs3 Dock3 Jag1 Nudc Cep97 Srgap1 Srgap2 Srgap3 Arhgap39 Dsp Pld2 Slc1a5 Dsg2 Dsg1a Tjp2 Uaca Ddx4 Cftr Rac1 Vav1 Pik3r1 Pik3r2 Ccp110 Pak1 Pak3 Pak2 Rac2 Vcp Pik3ca Lck Pard6a Rhoa Arhgef18 Csk Steap3 Arl13b Lman1 Mcf2l Rab7 Rhog Arhgdib Arhgdia Garre1 Arhgef16 Shmt2 Arhgdig Arfgap3 Erbin Emd Lemd3 Iqgap2 Lbr Diaph3 Cdc42ep1 Depdc1b Vrk2 Vamp3 Epha2 Dock5 Arhgef26 Itsn1 Arhgap5 Itgb1 Dock4 Arhgap1 Kalrn Arhgap21 Letm1 Vangl1 Mcam Ophn1 Stbd1 Ndufa5 Tpm3 Pld1 Dock1 Dock2 Vapb Elmo2 Stx5 Capzb Arhgap32 Gja1 Ykt6 Pak4 Prex1 Arhgap35 Cct6a Trio Mcf2 Esyt1 Tuba1b Plekhg3 Mtmr1 Mpp7 Ktn1 Ankle2 Muc13 Cyfip1 Tmpo Cct2 Actb Cct7 Sptan1 Abl2 Nck2 Nck1 Sptbn1 Rnd3 Ckb Sos2 Sema4f Nisch Aaas Kctd13 Tnfaip1 Pak6 Ckap4 Myo9b Pak5 Hsp90aa1 Rhou Ptk2b Wdr91 Usp9x Osbpl11 Wdr81 Arhgap4 Arap1 Arhgap9 Arhgap8 Fam91a1 Gmip Cltc Baiap2l2 Golga3 Vma22 Def6 Fgd5 Gopc Lrrc1 Ralgapa1 Wdr11 Arfgap2 Akap12 Tex2 Mospd2 Arhgap12 Arhgap19 Arhgap18 Efhd2 Arhgap22 Arhgap20 Arhgap25 Arhgap24 Arhgap23 Arhgap29 Arhgap28 Zap70 Whamm Arhgap33 Arhgap31 Sh3pxd2a Arhgap30 Dock11 Plekhg6 Plekhg4 Plekhg1 Mtr Ralbp1 Arhgap40 Arhgap44 Arhgap45 Filip1 Hint2 Ankfy1 Faf2 Rhoh Rhof Rhod Rhov Diaph2 Fam13b Shkbp1 Arhgap11a Emc3 Farp1 Kctd3 Cdc42ep2 Cdc42ep5 Cdc42ep3 Cdc42ep4 Syde2 Dnmbp Nsfl1c Rhpn1 Ccdc187 Acbd5 Basp1 Maco1 Ddrgk1 Ddx39b Spata13 Peak1 Gfod1 Srrm1 Rnd2 Dock6 Als2 Bltp3b Armcx3 Add3 Tor1aip1 Fmnl2 Fmnl1 Cdc42se2 Tmem87a Sh3bp1 Zfp512b Prag1 Sh3rf1 Itsn2 Scfd1 Picalm Trip10 Grb7 Vangl2 Aldh3a2 Epsti1 Stip1 Rnd1 Wdr6 Rras2 Stmn2 Kif14 Ccdc88a Tmem59 Fam83b Ubxn11 Plxna1 Fam135a Cpd Dlg5 Ankrd26 Pkp4 Rhob Anln Arhgef17 Slk Arhgef11 Arhgef10 Cavin1 Iqgap3 Diaph1 Daam1 Akap13 Cit Cav1 Arhgef25 Arhgef28 Sowahc Stom Pkn3 Arhgef3 Arhgef2 Arhgef1 Pcdh7 Ect2 Vav3 Myo9a Rtkn Iqgap1 Actc1 Jup Rhpn2 Stk10 Net1 Arhgef10l Stard8 Vav2 Dlc1 Stard13 Pkn2 Pkn1 Tiam2 Rhoc Plxnb1 Arhgef15 Map3k11 Arhgef19 Ngef Dbn1 Spen Twf1 Pde5a Msi2 Arhgef7 Tmod3 Myo6 Arhgef6 Txnl1 Phip Arhgef4 Gna13 Rbmx Fgd2 Actg1 Fgd1 Cops4 Fgd4 Tra2b Cops2 Fgd3 Stk38 Hsp90ab1 Arhgef39 Cpsf7 Arhgef40 Hnrnpc Stam2 Plekhg5 Actn1 Src Plekhg2 Cdc37 Rhobtb2 Rock2 Stam Rhobtb1 Rock1 Vim Rnf20 Hgs Hmox2 Ncf1 Ncf2 Ncf4 Atp6ap1 Brk1 Ocrl Swap70 Amigo2 Noxa1 Frs2 Rac3 Tfrc Git1 Baiap2 Kidins220 Bcap31 Arhgap15 Arhgap17 Nckap1l Fermt2 Bcr Arhgap6 Arap3 Lamtor1 Arap2 Rapgef1 Baiap2l1 Sos1 Arhgap26 Syde1 Abr Nckap1 Slitrk5 Slitrk3 Nhs Git2 Wasf2 Wasf1 Noxo1 Dock10 Racgap1 Taok3 Snap23 Cyba Abi2 Abi1 Cybb Nox3 Arhgap42 Nox1 C1qbp Dbt Arhgap10 Pgrmc2 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 96%5657560 Hereditary fructose intolerance Aldob MPS IIIA - SANFILIPPO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206307 MPS IIIA - Sanfilippo syndrome A Sgsh REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME%R-HSA-9768727.1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Ganab Jup Arhgap32 Pcsk7 Mogs Tmem258 Prkcsh Rpn2 Rpn1 Sec11c Sec11a Canx Stt3a Ctnnb1 Ostc Pip5k1c Csnk2a2 Cdh1 Spcs3 Spcs1 Spcs2 Furin Ank3 Pcsk6 Dad1 Pomt1 Pomt2 Ddost Csnk2b NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors P2ry13 P2ry6 P2ry12 P2ry2 P2ry14 P2ry1 Adora2b Lpar6 P2ry4 P2ry10 Ppan Gpr17 Adora1 Lpar4 Adora3 Adora2a NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes Bmal1 Nampt Bdnf Plk2 Xpo1 Syt10 Iqsec3 Mdm2 Rbfox3 Mapk1 Cdk5r1 Fos Mapk3 Ret Cdk5 Gem Crebbp Npas4 Ins2 Arnt DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 Abcb4 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B Abca12 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 Man1a Man1a2 Man1c1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Hadha Hadhb Acadl Eci1 Acadm Decr1 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 96%8857538 PTK6 promotes HIF1A stabilization Ptk6 Hbegf Hif1a Gpnmb Lrrk2 Egfr PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693616 Presynaptic phase of homologous DNA pairing and strand exchange Topbp1 Rpa2 Rad17 Rbbp8 Brca2 Brca1 Xrcc2 Rpa3 Rad1 Atm Kat5 Exo1 Nbn Rfc5 Rfc3 Rfc4 Rfc2 Hus1 Atrip Brip1 Dna2 Rad51c Rad51d Blm Rad51b Chek1 Rad9a Bard1 Rad9b Top3a Wrn Mre11a Sem1 Rad51 Rad50 Rpa1 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 96%8876198 RAB GEFs exchange GTP for GDP on RABs Dennd5b Dennd1b Dennd1c Rin3 Rin1 Rin2 Rab21 Chml Rab8a Mon1b Rab3a Dennd6a Mon1a Dennd6b Dennd2a Dennd2b Dennd2c Dennd2d Hps1 Rab12 Rab18 Hps4 Trappc12 Gapvd1 Rabgef1 Trappc11 Ywhae Trappc13 Rinl Ankrd27 Dennd3 Chm Trappc6b Trappc9 Trappc6a Trappc5 Trappc4 Trappc3 Rab35 Trappc2 Trappc1 Rab9 Rab5a Rab5c Rab8b Rab5b Rab1a Ulk1 Rab1b Trappc2l Rab9b Trappc10 Ric1 Sbf1 Rab27a Rab6b Rab6a Rgp1 Akt3 Akt2 Akt1 Rab7 Als2 Rab3ip Rab27b Sbf2 Als2cl Gdi1 Gdi2 Rab3il1 Dennd4c Dennd4a Dennd4b Rab39b Rab31 Rab10 Rab32 Rab13 Trappc8 Rab39 Rab14 Rab38 Dennd5a Rab3gap1 Dennd1a GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation Kcnj3 Kcnj2 Arhgef9 Gnal Gabrg2 Gabrg3 Gabra4 Gabra3 Gabra6 Gabra5 Gabbr1 Gabra2 Gabbr2 Gabra1 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Kcnj9 Adcy8 Kcnj6 Adcy5 Kcnj5 Adcy6 Kcnj4 Adcy9 Gabrr1 Gabrr3 Gabrr2 Gabrq Kcnj10 Gnai2 Gabrb1 Gnai1 Gabrb3 Gnai3 Gabrb2 Kcnj12 Kcnj15 Kcnj16 Gnat3 Gng10 Gng3 Gng2 Gng4 Gng7 Gng8 Gngt1 Gngt2 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) Slc5a5 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%450294 MAP kinase activation Mapk9 Mapk7 Mapk8 Ikbkb Jun Elk1 Ikbkg Map3k7 Map3k8 Nfkb1 Skp1 Fbxw11 Btrc Ubc Mapk1 Mapk3 Rps6ka3 Irak1 Mapkapk3 Rps6ka2 Traf6 Mapkapk2 Cul1 Ube2n Map2k7 Mapk14 Chuk Map2k6 Ppp2cb Ppp2ca Ube2v1 Map2k4 Tab3 Map2k3 Tab2 Tab1 Mapk10 Map2k1 Mapk11 Ripk2 Rps6ka5 Atf2 Rps6ka1 Vrk3 Ppp2r1b Ppp2r1a Tnip2 Nod2 Nod1 Dusp3 Dusp4 Dusp7 Dusp6 Irak2 Mef2a Fos Ppp2r5d Mef2c TRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6785470 tRNA processing in the mitochondrion Elac2 Hsd17b10 Prorp Trmt10c Trnt1 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation Psmb1 Psmb3 Psmb2 Psma7 Psma4 Psme2 Psme1 Psma3 Psma6 Psma5 Psmb10 Psma2 Psma1 Psmb9 Psmb8 Psmb5 Psmb4 Psmb7 Psmb6 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 96%186763 Downstream signal transduction Stat6 Rasa1 Nras Plcg1 Rapgef1 Sos1 Stat5a Crk Stat5b Hras Nck2 Ptpn11 Nck1 Bcar1 Pdgfrb Stat3 Stat1 Pdgfb Src Grb7 Pdgfra Pik3cb Pik3ca Crkl Pik3r1 Pik3r2 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 96%167044 Signalling to RAS Ngf Ralgds Nras Ntrk1 Sos1 Hras Mapk11 Shc3 Shc2 Shc1 Mapk12 Mapkapk3 Mapk13 Mapkapk2 Mapk14 Rala Ralb ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors Adrb3 Adra1b Adra1a Adra1d Adrb2 Adra2a Adrb1 Adra2c Adra2b NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes Mafk Ccl12 Nfe2l2 Crebbp Ep300 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-HSA-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes Havcr2 Angptl4 Plin1 Phf20 Mgll Cdk5 Tasp1 Akap8l Fabp4 Pex11a Hcfc1 Kat8 Yeats2 Wdr82 Kat14 Hcfc2 Dr1 Phf20l1 Ncoa3 Lpin1 Elovl5 Cidec Tada3 Nr5a2 Dgat2 Tada2a Bod1 Zzz3 Lipe Ppargc1b Plin4 Acsl1 Lpl Mbip Kansl3 Kansl1 Kansl2 Pnpla2 Bod1l Thrsp Phlda1 Sgf29 Ogt Agpat2 Adipoq H2ac20 Rxra Cd36 Cxxc1 Psip1 H2ac12 H2ac11 Plin2 H2ac15 H3c7 H2ax Ash2l Hist1h2bp H2aj Pdk4 Med4 Med23 Med6 Med24 Med20 Med27 Med12 Med13 Med14 Med10 H2bc9 H2bc7 H2bc8 H2bc3 Med16 Med17 Ncor2 H2ab2 Kdm6a H2bu2 Gps2 Rb1 Kat2b Kmt2c Kat2a Hist2h2aa1 Dpy30 Med30 Wdr5 Men1 Med31 Kmt2d Kmt2b H2bc14 Setd1b H2bc21 Setd1a H2bc26 Pagr1a Rbbp5 Abl1 Ncor1 Paxip1 Cdk8 Ep300 Tbl1x Ajuba Cebpa Hdac3 Scd1 Ncoa2 Ncoa1 Tbl1xr1 Ncoa6 Med1 Ppargc1a Ccnc Crebbp Sirt1 Gpam SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol Akr1c18 Cyp8b1 Ncoa2 Ncoa1 Rxra Nr1h4 Akr1c21 Hsd3b7 Cyp27a1 Akr1d1 Cyp7a1 Cyp7b1 Akr1c6 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME DATABASE ID RELEASE 96%9027277 Erythropoietin activates Phospholipase C gamma (PLCG) Epo Jak2 Epor Irs2 Plcg1 Lyn Plcg2 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 96%5675482 Regulation of necroptotic cell death Mlkl Birc3 Birc2 Peli1 Tradd Traf2 Sdcbp Prkn Fasl Xiap Tnfsf10 Tnfrsf10b Fadd Ube2l3 Flot2 Flot1 Cdc37 Itch Ripk3 Casp8 Ripk1 Stub1 Ubc Pdcd6ip Fas Ogt Hsp90aa1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 96%166016 Toll Like Receptor 4 (TLR4) Cascade Tlr4 Irf7 App Ikbkb Jun Plcg2 Birc3 Birc2 Peli1 Traf3 Ikbkg Map3k7 Ticam2 Traf2 Ticam1 Cd14 Btk Ikbke Tank Optn Nfkb1 Socs1 Skp1 Fadd Fbxw11 Rela Ripk3 Btrc Casp8 Ripk1 Ube2d3 Ubc Nfkbib Irak1 Nfkbia Cul1 Traf6 Dnm1 Ube2n Chuk Dnm3 Ube2v1 Trp53 Tab3 Sigirr Tab2 Tab1 S100a1 Irak3 Cd36 Tirap Rps6ka1 Tifa Alpk1 Nfkb2 Fos Fgb Fga Mapk9 Mapk7 Fgg Mapk8 S100a9 Elk1 S100a8 Tlr1 Tlr6 Tlr2 Map3k8 Ube2d1 Dnm2 Mapk1 Mapk3 Rps6ka3 Mapkapk3 Rps6ka2 Mapkapk2 Map2k7 Mapk14 Itgam Map2k6 Ppp2cb Ppp2ca Itgb2 Map2k4 Map2k3 Mapk10 Map2k1 Mapk11 Cd180 Ptpn11 Ly86 Ripk2 Lbp Tbk1 Myd88 Bpi Rps6ka5 Irf3 Nkiras1 Atf2 Nkiras2 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Ppp2r1a Peli2 Peli3 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Ptpn4 Usp18 Ppp2r5d Ly96 Mef2c VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity Slc6a14 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis Ppia ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173736 Alternative complement activation C3 Cfd Cfb Gzmm DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3359454 Defective TCN2 causes TCN2 deficiency Tcn2 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5675221 Negative regulation of MAPK pathway Dusp5 Ppp2cb Paqr3 Ppp2ca Dusp1 Dusp10 Dusp9 Map2k2 Ptpn7 Dusp8 Ksr1 Nras Map2k1 Araf Mark3 Ppp2r5e Pebp1 Raf1 Hras Ppp2r1b Ppp2r1a Ppp5c Dusp4 Dusp16 Dusp7 Dusp6 Ubc Mapk1 Braf Mapk3 Ppp2r5d Ywhab Ppp2r5c Mapk12 Ppp2r5b Brap Ppp2r5a Dusp2 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) Tlr5 Myd88 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%189451 Heme biosynthesis Fech Uros Ppox Cox10 Alad Alas1 Alas2 Hmbs Cox15 Cpox Urod Abcg2 Alb DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9920588 Dengue virus activates modulates innate and adaptive immune responses Clec5a Mbl2 Ddx3x Cgas Sting1 Cdc73 Rtf1 Vtn Leo1 Skic8 Ikbke Stat2 Exoc1 Ifih1 Hsp90ab1 Trim25 Ctr9 Mavs Paf1 Rbm10 Clu C4a C1qa Ubr4 Hsp90aa1 Apoa1 C1s2 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 96%8964038 LDL clearance Ap2a2 Npc2 Ap2a1 Npc1 Ldlr Nceh1 Ap2b1 Ces3b Ap2s1 Clta Ap2m1 Lipa Ldlrap1 Cltc Soat2 Soat1 Pcsk9 Lsr Apob ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins Pard6a Psma4 Psma3 Psma6 Psma5 Psma2 Prickle1 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Smurf2 Smurf1 Dvl2 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fzd1 Vangl2 Fzd3 Fzd2 Psma7 Psmc6 Fzd5 Psmc5 Fzd4 Psmc2 Fzd7 Psmc1 Psmc4 Psmc3 Scrib Fzd8 Ubc Wnt5a Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%5660489 MTF1 activates gene expression Csrp1 Sncb Mtf1 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins Cbx8 Rnf2 Phc2 Phc1 Cbx4 Cbx2 Dnmt3a Dnmt3b Dnmt1 Phc3 Ube2i Bmi1 Pcgf2 Ring1 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811436.2 COPI-independent Golgi-to-ER retrograde traffic Capzb Capza1 Capza2 Rab6b Rab6a Actr1a Dync1li2 Dctn2 Dctn3 Dync1li1 Rab18 Pafah1b3 Pafah1b2 Actr10 Dctn5 Dynll1 Galnt2 Dctn6 Dctn1 Dynll2 Dctn4 Capza3 Bicd2 Bicd1 Pla2g4a Dync1h1 Dync1i2 Dync1i1 Agpat3 Pafah1b1 Pla2g6 Galnt1 Rab3gap1 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9675108 Nervous system development Col4a1 Pitpna Cyp51a1 Plxnd1 Srebf2 Col4a2 Col9a2 Dlg1 Col9a3 Dlg3 Col6a6 Mmp9 Dlg4 Col6a3 Ppp3cb Col4a5 Col9a1 Arpc1b Actr2 Arpc1a Cdk5r1 Ap2m1 Actr3 Sdcbp Cdk5 Prkacb Arpc3 Arpc2 Ap2a2 Ap2a1 Arpc5 Arpc4 Rbx1 Ap2b1 Ap2s1 Reln Vldlr Dab1 Wasl Myo10 Sdc2 Gdnf Gfra1 Prkaca Rasa1 Mapk7 Epha1 Neo1 Gpc1 Ncan Rps6ka6 Agrn Clasp1 Clasp2 Rps6ka3 Rps6ka2 Farp2 Tiam1 Gab1 Plcg1 Egr2 Grin2b Rps27 Adam10 Efna1 Efna2 Efna3 Mmp2 Epha3 Epha4 Epha5 Epha6 Epha7 Epha8 Ephb1 Ephb3 Ephb4 Ephb6 Efnb1 Efnb2 Efnb3 Efna4 Efna5 Robo1 Srgap1 Mag Srgap2 Srgap3 Arhgap39 Slit2 Nab1 Nab2 Prkca Cacna1c Lyn Yes1 Grin1 Myh9 Csnk2a2 Myl12a Erbb2 Rac1 Pik3r1 Pik3r2 Yap1 Unc5b Unc5a Pak1 Pak3 Pak2 Tead1 Ret Fes Pik3cb Pik3cd Pik3ca Wwtr1 Csnk2b Gsk3b Itga5 Rhoa Ptpn11 Fyn Rps6ka5 Abl1 Epha2 Itsn1 Ncbp2 Cacna1g Ncbp1 Myl12b Itgb1 Cacna1h Kalrn Myh11 Cacna1i Eloc Dock1 Myl6 Cacna1d Pak4 Arhgap35 Trio Sema5a Actb Spta1 Nrp2 Scn9a Scn5a Sptb L1cam Scn1a Scn1b Lypla2 Kcnq3 Itgav Kcnq2 Numb Ptk2 Shtn1 Gap43 Ank3 Chl1 Nell2 Msi1 Ank1 Scn10a Cxcr4 Dag1 Scn2a Isl1 Scn2b Upf3a Dnm1 Pfn1 Kif4 Sptan1 Gspt2 Gspt1 Dnm3 Pfn2 Rps6ka4 Vasp Dcx Ranbp9 Cxcl12 Abl2 Ezr Lhx2 Scn7a Lhx3 Shank3 Scn11a Cul2 Scn3a Lhx9 Scn3b Lhx4 Ephb2 Itga9 Nrp1 Pabpc1 Itga10 Dpysl2 Flrt3 Alcam Slit1 Nfasc Slit3 Nck2 Scn8a Rdx Akap5 Nck1 Ncam1 Cap1 Msn Dcc Itga2b Nrcam Upf2 Scn4a Sptbn1 Usp33 Zswim8 Scn4b Sptbn2 Evl Etf1 Cntn2 Sos2 Cntn1 Cntnap1 Robo2 Cntn6 Hoxa2 Sptbn4 Ntn1 Pak6 Myo9b Pak5 Cap2 Prkar2a Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 St8sia4 Rps10 Rps11 Rpl7 Hsp90aa1 Rpl32 Cacnb3 Cacnb4 Rps9 Rps7 Cacnb1 Rps5 Rpl24 Cacnb2 Rpl26 Rpl22 Rpl23 Rps25 Rps26 St8sia2 Rps21 Rpl39l Rps15a Clta Cltc Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Cltb Rps3 Rps4x Dnm2 Hspa8 Egfr Irs2 Rnps1 Hdac2 Gab2 Magoh Rbm8a Smarca4 Upf3b Itga1 Itga2 Eif4a3 Casc3 Magohb Pou3f1 Trpc6 Trpc5 Cfl1 Trpc7 Siah2 Trpc1 Trpc4 Trpc3 Grb10 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Lama1 Psmd12 Psmd11 Psmd14 Lama2 Psmd13 Lamc1 Lamb1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Grb7 Psma7 Psmc6 Pip5k1c Psmc5 Psmc2 Rnd1 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Plxna1 Psmd8 Psmd3 Plxna4 Psmd2 Psmd1 Adrm1 Sem1 Prkcq Ldb1 Rps6ka1 Agap2 Crmp1 Dscaml1 Adgrg6 Rap1gap Utrn Tyrobp Mbp Ptprc Ptpra Pou3f2 Ntn4 Sox10 Unc5d Rhob Trem2 Unc5c Sema7a Arhgef11 Rgmb Rgma Artn Prx Gfra2 Gfra3 Gfra4 Siah1a Drp2 Dpysl3 Arhgef28 Dpysl4 Dpysl5 Cd72 Plxnb3 Cacna1s Mpz Plxna3 Plxna2 Dok1 Vav3 Dok2 Dscam Dok4 Dok5 Dok6 Prnp Pspn Plxnc1 Vav2 Nrtn Sema6d Sema6a Hjv Sema4a Itgb3 Ablim1 Rhoc Ablim2 Plxnb1 Ablim3 Tln1 Pmp22 Sema3a Ngef Adgrv1 Hmgcr Sema3e Arhgef7 Actg1 Hsp90ab1 Src Sh3kbp1 Rock2 Rock1 Myh14 Myh10 Sema4d Rras Limk1 Limk2 Sh3gl2 Met Shc3 Shc1 Mapk1 Mapk3 Eif4g1 Frs2 Git1 Map2k2 Nras Map2k1 Sos1 Hras Psen1 Psen2 Ncstn Aph1b Col6a1 Col4a3 Col6a2 Col4a4 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance Cenpc1 Itgb3bp Cenpu Cenpt Cenps Cenpq Cenpp Cenpo Cenpn Cenpm Cenpl Cenpk Cenpi Cenph Ppp6r3 Ppp6c Npm1 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Rsf1 Polr2i Oip5 Polr2j Mis18a Cenpx Cenpw Mis18bp1 Wrap53 Ankrd28 H2ac20 Tert Lig1 Rfc5 Pold2 Pold1 Rfc3 Pcna H2ac12 Rfc4 H2ac11 Rfc1 Rfc2 Pold4 Pold3 H2ac15 Dna2 H2ax Blm Hist1h2bp H2aj Wrn Dkc1 Rpa1 Nhp2 Rpa2 Rtel1 Gar1 H2bc9 Rpa3 H2bc7 H2bc8 Tinf2 H2bc3 Nop10 Shq1 Dscc1 Ruvbl2 Pif1 Ruvbl1 Chtf18 H2ab2 Ctc1 H3c8 Chtf8 Stn1 Ten1 H2bu2 Acd Atrx Terf2ip Cdk2 Ccna1 Ccna2 Terf2 Daxx Terf1 Hist2h2aa1 Fen1 Pot1 Knl1 H2bc14 H2bc21 H2bc26 Rbbp4 Rbbp7 Prim2 Prim1 Pola2 Pola1 Smarca5 Cenpa PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 96%9824443 Parasitic Infection Pathways Elmo2 Adora2b Entpd1 Nt5e Entpd5 C3ar1 Ggt1 Prkx Jun Il18 Plcg2 Cyfip1 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Btk Dpep1 Dpep2 Nfkb1 Dvl1 Dvl2 Dvl3 Prkacb Actb Myo5a Ggt5 Arpc3 Arpc2 Nlrp3 Pstpip1 Cyfip2 Rela Arpc5 Arpc4 Ctsg Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Casp1 Adcy5 Adcy6 Gnaz Wnt5a Fcgr1 Gsdmd Adcy9 Fcgr3 Il1a Fcgr4 Il1b Ptk2 Syk Mefv Fgr Myh2 Gnai2 Gnai1 Gnai3 Myo1c Nckipsd Prkar1b Was Wasf3 Pycard Gnat3 Prkar2b Cysltr2 Cysltr1 Wasl Sugt1 P2rx7 Gng10 P2rx4 Myo10 Nck1 Gng3 Gng2 Prkar1a Gng4 Gng7 Gng8 Myo9b Lyn Yes1 Prkar2a Gngt1 Gngt2 Rhbdf2 Il10 Cd163 Plk2 Fzd7 Myh9 Ahcyl1 Nfkb2 Rac1 Gnb2 Gnb1 Vav1 Gnb4 Txnip Gnb3 Gnb5 Gng11 Gng12 Gng13 Vav3 Prkaca Cd3g Itpr3 Itpr2 Vav2 Itpr1 Mapk8 Txn Actg1 Il6 Hsp90ab1 Mapk1 Mapk3 Furin Brk1 Mapk14 Noxa1 Baiap2 Nckap1l Plcg1 Crk Nckap1 Fyn Wasf2 Wasf1 Noxo1 Abl1 Cyba Abi2 Abi1 Hmox1 Adam17 Nox1 C3 Elmo1 Hck Dock1 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN Xrcc6 Xrcc5 Tbk1 Nlrc3 Irf3 Nlrp4e Dtx4 Sting1 Mre11a Ddx41 Prkdc Trex1 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.1 Aggregated β-amyloid induces FXII autocatalysis F12 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors Hcrt Npff Npffr1 Npffr2 Hcrtr2 Hcrtr1 Qrfpr Qrfp NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-HSA-2995410.7 Nuclear Envelope (NE) Reassembly Tnpo1 Tuba1b Tuba1a Tuba1c Spast Ankle2 Tubal3 Lemd2 Nup133 Cc2d1b Chmp2a Ist1 Vrk1 Sirt2 Tubb2b Chmp3 Cdk1 Tubb2a Chmp7 Chmp6 Lmnb1 Tuba4a Chmp4c Ran Chmp4b Tuba8 Ppp2r2a Tuba3b Nup37 Nup160 Tubb6 Ppp2ca Tubb3 Nup43 Tubb1 Tubb4b Tubb4a Nup93 Nup35 Nup54 Pom121 Nup205 Ube2i Nup188 Ahctf1 Nup107 Ndc1 Nup62 Banf1 Nup155 Ppp2r1a Emd Lemd3 Lbr Ccnb2 Nup85 Rcc1 Vps4a Kpnb1 Sec13 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing Adar Apobec4 Apobec2 Apobec3 A1cf Apobec1 Adarb1 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD Abca1 Apoa1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Pcna Rpa2 Pold4 Pold3 Rpa3 Lig1 Exo1 Msh2 Msh3 Pold2 Pms2 Pold1 Mlh1 Rpa1 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception Or51a5 Or2z8 Or51d1 Or4x11 Or6a2 Or9g8 Or9g4 Or51b17 Or52e4 Or52e2 Or6b3 Or6b2 Or6b1 Or13c7d Or2t1 Awat2 Or9a4 Or51f2 Or52h1 Or10p1 Or5h19 Or5h17 Or5h18 Or2t6 Fnta Or1s2 Fntb Or51e2 Or51e1 Rlbp1 Lrp1 Or2v2 Or52j3 Or4d10c Or5ak23 Or10j27 Bco2 Bco1 Or51g2 Or2w1 Apoa2 Ldlr Or2w3 Adcy3 Or8b8 Myo3a Cyp4v3 Apoa4 Myo3b Or51g1 Fscn2 Or52i2 Xirp2 Or8b4 Or8b3 Grxcr2 Eps8 Or10q1 Lpl Gpihbp1 Rcvrn Grxcr1 Or5h26 Kcnq4 Or5h25 Myo7a Pls1 Or4f15 Pcdh15 Or13j1 Tmc1 Apoc2 Or10g1b Or8b12i Espnl Ush1g Or4c3 Tmc2 Or3a1 Or4d2 Cib2 Lhfpl5 Or4d1 Or5b99 Otog Slc26a5 Apoc3 Or6c76 Whrn Myo1c Or6c75 Or6c74 Twf2 Or4d6 Clic5 Or4d5 Epb41l3 Tmie Or10c1 Strc Or11h4 Or4n4b Cdh23 Gnat3 Ush1c Hsd17b6 Otogl Or7c70 Or2a7 Mpp1 Gsn Or10h1b Or2a5 Pjvk Eps8l2 Or10h28 Or5m10 Espn Myo15a Hsd17b1 Tprn Or11h6 Or7a36 Ripor2 Or11g2 Or2b6 Or2c1 Rpe65 Apom Or6k6 Kcnmb1 Or10ag2 Retsat Kcnma1 Kcnn2 Or5i1 Chrna10 Or6k2 Hspg2 Or9q2 Or9q1 Sdc4 Or8b12 Sdc3 Calhm1 Sdc2 Or10h5 Rdh8 Or6c6 Or8a1b Or6c3 Or5a1 Or5l14 Or5l13 Camkmt Or10g3 Or7a41 Gngt1 Or5b3 Or9k2 Or4k15 Or8i2 Or10g9 Or5p80 Or10g7 Sdc1 Or10j5 Otop1 Or11l3 Or5c1 Or5k16 Or8j3 Or6f1 Or52b2 Or52a20 Or2ag2 Or8k3 Gnb1 Or2ag1 Akr1b10 Gnb3 Or8k1 Or52e8b Atp2b1 Or52a5 Guca1b Gng13 Guca1a Or8g20 Or10g9b Or51s1 Or2h2 Or9i1b Or2h1 Or6p1 Itpr3 Or4l1 Or4b1d Or8u9 Or4m1 Or13a1 Or4a15 Or8u3 Or5ap2 Or5d43 Kcnj2 Or5as1 Or5b107 Cask Or2m13 Gpc1 Lrp10 Lrp12 Gnal Grk1 Gpc3 Or52w1 Gpc2 Or4n5 Or5p6 Gpc5 Or2j3 Or56b1b Gpc4 Or4n4 Or4a47 Gpc6 Or13d1 Or7d11 Or5ar1 Or5b21 Or10ad1c Or51t4 Or2m12 Or13c3 Or1i2 Or2k2 Or6s1 Rtp2 Rtp1 Or5au1 Or4g7 Metap1 Metap2 Or1b1 Or2d2 Or5j3 Or13f5 Or4a68 Or6c1b Or5k8 Or2l13 Or5k1 Agrn Or11a4 Or8g51 Or6c65 Abca4 Or14j1 Or1d2 Or2f2 Or2f1 Or6n2 Or6n1 Or6c68 Or13g1 Or1j19 Or5m8 Or5m9 Or5ac16 Or4k2 Or5m3 Or56a5 Or4k5 Or1e1 Or10a3 Or12d17 Ebf1 Or10a4 Or56a4 Or10a5 Or4k1 Or4a79 Or12d12 Or10a2 Slc24a1 Sag Rho Gnat1 Cnga1 Clps Pnlip Ano2 Scnn1a Scnn1b Scnn1g Plb1 Nmt2 Plcb2 Pde6g Prkca Pde6a Pde6b Tas1r2 Tas1r1 Tas1r3 Tas2r137 Tas2r136 Myh9 Tas2r140 Tas2r4 Nmt1 Tas2r7 Cnga4 Cnga2 Tas2r39 Tas2r38 Ttr Tas2r16 Tas2r13 Opn1mw Tas2r40 Tas2r41 Opn1sw Tas2r119 Grm4 Tas2r120 Tas2r107 Cacna1d Capzb Lrrc52 Capza1 Capza2 Bsn Syp Otof Cabp2 Slc17a8 Pclo Scn9a Scn1b Scn2a Scn2b Sptan1 Ezr Lhx2 Scn3a Rdx Msn Sptbn1 Scn4b Syn1 Cacna2d2 Cacnb2 Rab3a Dnajc5 Grm1 Apoe Trpm4 Trpm5 Lrp2 Akr1c21 Akr1c6 Prkcq Ldb1 Twf1 Or5v1 Or6x1 Or1a1b Or52l1 Or1n1 Or1n2 Or6y1 Or51i2 Or2t44 Or51i1 Or52k2 Or8k16 Or7e178 Or2t45 Or10s1 Rbp4 Rbp2 Rbp3 Chrna9 Rbp1 Or13c25 Or2b11 Rdh12 Or52n4 Or52n5 Or52n2 Or2b2b Or10a3b Or10w1 Or2a25 Or4c106 Or2at4 Or1q1 Or52m1 Or51f1d Or10v1 Or4f58 Or4d10 Or4d11 Lrat Or2a12 Or7g19 Or2l5 Or1j4 Or5d18 Or4c29 Or1j1 Or5m10b Or5d16 Or5d14 Or14c46 Or52z13 Or51m1 Gucy2e Or10x1 Or4c15 Or4c11 Or4c12 Or4q3 Snap25 Or4c10 Gucy2f Or3a1d Or3a1c Or51q1 Vamp2 Or56a3b Or1l8 Dhrs3 Stx1a Or5t9 Rdh11 Or1l4 Or7g34 Rdh10 Or4s2b Or7g33 Akr1c18 Or5t5 Or8h10 Or5t17 Or52r1 Or10z1 Rdh16f2 Or5m11b Or2a57 Or5an1 Rdh5 Or5b12b Or2a56 Dhrs9 Or1m1 Reep1 Or52d1 Or1e1c Rgs9bp Ppef1 Stra6 Or14a259 Or14a257 Or51b6 Or51b4 Or2l13b Or10k2 Or8d4 Or8d6 Or2y1 Apoa1 Or8d1 Sdr9c7 Or51a7 Apob TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation Smad1 Ppara Smad4 Pparg Hdac2 Hdac1 Rxra Gatad2a Gatad2b Rbbp4 Rbbp7 Mbd3 Chd3 Chd4 Ucp1 Hnrnpu Elovl3 Mta1 Cidea Mta3 Ncoa1 Prdm16 Ebf2 Ppargc1b Bmp7 Zfp423 Mta2 Cox7a1 Ppargc1a NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%383280 Nuclear Receptor transcription pathway Rorc Rxrg Thrb Nr2c1 Rorb Vdr Hnf4a Nr1h2 Rora Ppara Esr1 Pparg Hnf4g Nr1d2 Ar Rxra Esrra Rara Ncor2 Pgr Nr5a1 Esrrb Esrrg Nr4a2 Ncor1 Nr2f6 Nr0b2 Nr2f1 Thra Nrbp1 Nr4a1 Rarb Ppard Nr2e1 Nr2c2 Rarg Med1 Nr1d1 Nr2c2ap Rxrb Esr2 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 96%936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Tlr4 Irf7 Ubc Ptpn11 Tbk1 Traf3 Irf3 Ticam2 Ticam1 Cd14 Ikbke Tank Ly96 Optn VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 96%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) Slc6a20a FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-HSA-75105.12 Fatty acyl-CoA biosynthesis Elovl6 Olah Hsd17b8 Hsd17b3 Acly Elovl4 Hacd1 Morc2a Hsd17b12 Elovl1 Hacd2 Hacd3 Elovl7 Hacd4 Cbr4 Tecrl Tecr Acsbg1 Acsbg2 Acsl5 Elovl3 Elovl5 Ppt2 Acsl6 Scd1 Acsl3 Slc27a3 Slc27a2 Ppt1 Acsl4 Acsf3 Acsl1 Acaca Fasn IMPAIRED BRCA2 BINDING TO PALB2%REACTOME%R-HSA-9709603.2 Impaired BRCA2 binding to PALB2 Rbbp8 Brca2 Brca1 Rad51ap1 Brip1 Xrcc2 Dna2 Rad51c Rad51d Atm Blm Rad51b Bard1 Top3a Kat5 Exo1 Wrn Mre11a Nbn Palb2 Rad51 Rad50 ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 96%1482922 Acyl chain remodelling of PI Pla2g2e Pla2g2d Pla2g4a Pla2g2f Pla2g4d Pla2g12a Pla2g5 Mboat7 Pla2g1b Pla2r1 Pla2g4f Pla2g4c Pla2g4e Pla2g10 Plbd1 Plaat3 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 96%1234174 Cellular response to hypoxia Vhl Cited2 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Ube2d1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Vegfa Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Ube2d3 Psmc3 Ubc Psmd7 Hif3a Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Epas1 Sem1 Cul2 Hif1a Ep300 Arnt Ajuba Epo Car9 Egln2 Egln3 Hif1an Wtip Limd1 Crebbp Eloc NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5676590 NIK-->noncanonical NF-kB signaling Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Relb Uba3 Psmd12 Psmd11 Map3k14 Psmd14 Psmd13 Skp1 Psmb5 Ube2m Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Nfkb2 Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Chuk CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 96%5218900 CASP8 activity is inhibited Tradd Traf2 Fas Fasl Casp8 Tnfsf10 Ripk1 Tnfrsf10b Fadd RHOA GTPASE CYCLE%REACTOME%R-HSA-8980692.2 RHOA GTPase cycle Vapb Stx5 Arhgap32 Ykt6 Prex1 Arhgap35 Trio Mcf2 Plekhg3 Ktn1 Srgap1 Tmpo Arhgap39 Scfd1 Flot2 Flot1 Tjp2 Aaas Myo9b Anln Arhgef17 Slk Arhgef11 Arhgef10 Cavin1 Iqgap3 Fmnl3 Diaph1 Daam1 Akap13 Cav1 Cit Arhgef25 Arhgef28 Sowahc Vav1 Stom Pkn3 Arhgef3 Arhgef2 Arhgef1 Pik3r1 Pik3r2 Pcdh7 Ect2 Vav3 Myo9a Rtkn Iqgap1 Actc1 Jup Rhpn2 Stk10 Net1 Arhgef10l Stard8 Vav2 Dlc1 Stard13 Pkn2 Pkn1 Arhgef15 Arhgef19 Ngef Arhgap4 Arap1 Arhgap9 Arhgap8 Arhgef7 Gmip Arhgef4 Vma22 Def6 Rasgrf2 Tex2 Arhgef40 Plekhg5 Arhgap19 Arhgap18 Rock2 Arhgap22 Rock1 Arhgap20 Arhgap24 Arhgap23 Hmox2 Arhgap29 Arhgap28 Arhgap31 Arhgap30 Plekhg6 Abcd3 Plekhg4 Arhgap40 Arhgap44 Arhgap45 Atp6ap1 Faf2 Tfrc Bcap31 Tiam1 Arhgap11a Bcr Emc3 Arhgap6 Farp1 Arap3 Arap2 Arhgap26 Abr Rhoa Arhgef18 Rhpn1 Acbd5 Maco1 Ddrgk1 Racgap1 Lman1 Snap23 Mcf2l Arhgdib Arhgdia Arhgap42 Erbin C1qbp Tmem87a Lbr Diaph3 Depdc1b Vamp3 Arhgap5 Arhgap1 Arhgap10 Kalrn Pgrmc2 Arhgap21 Vangl1 Mcam Ophn1 Stbd1 Pld1 Dock2 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665686 Signaling by ERBB2 TMD JMD mutants Nrg3 Cdc37 Erbin Nras Nrg1 Plcg1 Sos1 Hras Egfr Erbb2 Egf Shc1 Ereg Hbegf Btc Hsp90aa1 Nrg2 Nrg4 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME%R-HSA-9022699.2 MECP2 regulates neuronal receptors and channels Trpc3 Sin3a Gria2 Hdac2 Hdac1 Met Grin2b Ptpn4 Slc2a3 Ptpn1 Gprin1 Fkbp5 Oprk1 Grin2a Oprm1 ACTIVATION OF PKB%REACTOME%R-HSA-165158.6 Activation of PKB Them4 Akt2 Pdpk1 Trib3 PDGFR MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9674428 PDGFR mutants bind TKIs Pdgfra SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855183 Synthesis of IP2, IP, and Ins in the cytosol Mtmr7 Inpp4a Inpp4b Mtmr9 Miox Inpp5a Impa2 Impa1 Isyna1 Inpp1 Synj1 Inpp5b Ocrl REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 96%381426 Regulation of IGF Activity by IGFBP Scg3 Scg2 Meltf Qsox1 Mxra8 Fam20a Apoe Fam20c Fuca2 Stc2 Serpina10 Hrc Ambn Mepe Mia3 Pappa2 Aplp2 App Enam Ktn1 Bmp15 Bpifb2 Fn1 Igfals Plg Igfbp6 Matn3 Rcn1 Lamb2 Vwa1 Timp1 Fstl3 Prss23 Tmem132a Afp Igfbp2 Igfbp5 Lamc1 Igfbp4 Lamb1 Golm1 Amtn Serpind1 Nucb1 Sparcl1 Msln Itih2 Vgf Notum Klk13 Apoa2 Ltbp1 Ctsg F5 Apoa5 Fstl1 Pnpla2 Alb Serpina1d Pcsk9 P4hb Cdh2 Igf2 Igf1 Mgat4a Prkcsh Sdc2 Pdia6 Ckap4 Csf1 F2 Mmp1a Igfbp3 Bmp4 Wfs1 Igfbp1 Fga Fgg Kng2 Dnajc3 Gpc3 Vcan Spp1 Proc Il6 Serpinc1 Mfge8 Cp Cst3 Tf Gas6 Igfbp7 Tnc Penk Men1 Gzmf Fbn1 Fgf23 Adam10 Calu Ahsg Spp2 Hsp90b1 C3 C4a Mmp2 Chgb Eva1a Dmp1 Mbtps1 Ccn1 Shisa5 Apoa1 Amelx Pappa Lgals1 Apob Ano8 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex Gtf2h3 Gtf2h5 Usp7 Ercc2 Ccnh Ercc3 Cdk7 Aqr Ercc8 Ddb1 Isy1 Xpa Cul4a Cul4b Cops4 Cops3 Cops6 Cops2 Cops8 Cops7a Uvssa Cops7b Znf830 Ercc6 Rbx1 Polr2c Ubc Cops5 Polr2d Polr2a Polr2b Polr2g Tcea1 Polr2h Polr2e Polr2f Xab2 Polr2k Mnat1 Polr2i Polr2j Ppie Gtf2h2 Prpf19 Gtf2h1 Gtf2h4 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 H2bc3 H2bc21 H2bc26 H2ab2 Kpna1 H2bu2 H2ac12 H2ac11 Orc5 Orc4 Orc6 Orc1 H2ac15 Orc3 H3c7 Orc2 H2ax Hist1h2bp Hist2h2aa1 H2aj Kpnb1 Kpna6 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 96%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 Ppp2cb E2f1 Ppp2ca Prim2 Prim1 Pola2 Pola1 Tfdp2 Tfdp1 Rb1 Ppp2r1b Ppp2r1a TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT Ppp2r5e Psma4 Psma3 Psma6 Psma5 Pip5k1b Psma2 Psma1 Psmd12 Psmd11 Tle3 Psmd14 Xiap Psmd13 Smurf2 Dvl1 Dvl2 Dvl3 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Runx3 Psmb3 Psmb2 Sox3 Btrc Trrap Rbx1 Psma7 Sox7 Psmc6 Sox6 Psmc5 Pygo2 Psmc2 Sox4 Usp8 Psmc1 Pygo1 Psmc4 Dkk1 Psmc3 Dkk2 Ubc Wnt5a Dkk4 Rnf43 Wnt9a Psmd7 Sox13 Psmd6 Kremen2 Kremen1 Bcl9l Psmd8 Bcl9 Psmd3 Cby1 Psmd2 Znrf3 Psmd1 Csnk1g2 Sfrp2 Adrm1 Sem1 Sfrp1 Rspo1 Rspo2 Rspo4 Chd8 Lrp6 Wnt8b Lrp5 Wnt8a Wif1 Ccdc88c Ryk Ctnnbip1 Lgr4 Sost Lgr5 Lgr6 Rnf146 Frat2 Tnks2 Frat1 H2ac20 Tnks Tert Hdac1 Myc Sox9 Akt2 Akt1 Kat5 Wnt3a Tcf7l1 Tcf7l2 Ywhaz Wnt1 H2ac12 Wnt4 H2ac11 Wnt3 Fzd1 H2ac15 Fzd2 H3c7 Fzd5 Fzd4 H2ax Axin2 Fzd6 Csnk2a2 Fzd8 Ash2l Cav1 Hist1h2bp H2aj Axin1 H2bc9 Hecw1 Rspo3 H2bc7 Klhl12 Cul3 H2bc8 H2bc3 Cdc73 Leo1 Ruvbl1 H2ab2 H3c8 H2bu2 Ctnnb1 Tcf7 Hist2h2aa1 Ctbp1 Dpy30 Amer1 Wdr5 Men1 Csnk2b Tle4 Ppp2cb Ppp2ca Tle2 Tle1 Gsk3b Csnk1e Kmt2b Lef1 Csnk1a1 H2bc14 H2bc21 H2bc26 Rbbp5 Sox17 Smarca4 Ep300 Ppp2r1b Apc Ppp2r1a Sox2 Xpo1 Ppp2r5d Ppp2r5c Ppp2r5b Crebbp Ppp2r5a SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells Sos1 Gab3 Thoc5 Grap2 Csf1r Ptpn11 Gab2 Plcg2 Fyn Il34 Stat3 Stat1 Inpp5d Csf1 Lyn Yes1 Src Inppl1 Cbl Pik3cb Pik3cd Ubc Kras Pik3ca Shc1 Hck Pik3r1 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 96%392517 Rap1 signalling Prkaca Rasgrp2 Rap1gap Rap1b Rasgrp1 Sipa1 Raf1 Rap1gap2 Rapgef4 Rapgef3 Ywhab Rap1a Prkacb Ywhaz SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 Dph1 Dph2 Dph3 Dnajc24 Dph5 Dph6 Eef2 Dph7 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching Robo2 Slit1 Robo1 Nck2 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 96%4420097 VEGFA-VEGFR2 Pathway Prkaca Elmo2 Jup Pak1 Itpr3 Vav2 Itpr2 Rasa1 Pak3 Itpr1 Pak2 Ptk2b Itgb3 Cyfip1 Bcar1 Rictor Prkacb Sphk1 Cyfip2 Rock2 Ctnnb1 Prkcb Rock1 Pik3cb Ctnnd1 Kdr Pik3ca Shc2 Axl Itgav Ptk2 Prr5 Ncf1 Mapk12 Ncf2 Ncf4 Pdpk1 Mapkapk3 Brk1 Mapk13 Mapkapk2 Mapk14 Wasf3 Cdh5 Them4 Baiap2 Nckap1l Mlst8 Nras Pxn Plcg1 Prkca Crk Mtor Hras Trib3 Rhoa Nck2 Mapk11 Shb Nckap1 Prkcz Nck1 Sh2d2a Fyn Nos3 Akt3 Akt2 Akt1 Wasf2 Wasf1 Hspb1 Mapkap1 Cyba Abi2 Abi1 Cybb Prkcd Ahcyl1 Rac1 Cav1 Vav1 Elmo1 Ctnna1 Hsp90aa1 Pik3r1 Pik3r2 Vav3 Dock1 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-HSA-9933947.1 Formation of the non-canonical BAF (ncBAF) complex Smarcd1 Ss18 Actl6a Smarcd2 Smarcc2 Ss18l1 Smarcc1 Bcl7a Bcl7b Bcl7c Smarcd3 Bicral Bicra Brd9 Smarca2 Smarca4 Actb MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) Idua REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity Mafk Bach1 H13 Nfe2l2 Hmox1 FRUCTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70350 Fructose catabolism Khk Aldh1a1 Tkfc Aldob Glyctk MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 96%2132295 MHC class II antigen presentation Capzb Capza1 Ctsk Capza2 Ctsl Actr1a Dctn2 Dctn3 Ctsc Clta Ap2m1 Cltc Cenpe Ctsd Ap1m2 Arf1 Ap1m1 Ap1s3 Ap1s2 Ap2a2 Ap1b1 Ap1s1 Ap2a1 Canx Ap1g1 Sec31a Dnm2 Sh3gl2 Ap2b1 Ap2s1 Kif3a Kif3b Kif3c Kif5b Dnm1 Kif4 Dnm3 Kif2a Kif2b Kif2c H2-Eb1 Dync1li2 Ifi30 Dync1li1 Cd74 Ctse Actr10 Sptbn2 Ctsf Dctn5 Dynll1 Actr1b Dctn6 Dctn1 Dynll2 Racgap1 Ctsh Dctn4 Kif26a Capza3 Rab7 Ctso Kif11 Kif15 Lag3 H2-DMa H2-Ob Kif22 Kif23 Kif18a H2-Oa Rilp Dync1h1 Kif20a Osbpl1a Klc1 Sar1b Klc4 Klc3 Klc2 Sec23a H2-DMb2 Ctsb Ctss Dync1i2 Dync1i1 Lgmn Ctsa Sec24d Sec24c Kifap3 Sec24b Sec13 Sec24a REPRESSION OF WNT TARGET GENES%REACTOME%R-HSA-4641265.5 Repression of WNT target genes Tle4 Tle2 Tle1 Ctbp1 Tle3 Ctbp2 Tcf7 Lef1 Tcf7l1 Tle5 Tcf7l2 Hdac1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Acot8 Elovl3 Elovl5 Hsd17b4 Acaa1a Scp2 Abcd1 Elovl1 Acsl1 Fads2 Fads1 HOST INTERACTIONS OF HIV FACTORS%REACTOME%R-HSA-162909.3 Host Interactions of HIV factors Ppia Psma4 Psma3 Psma6 Psma5 Nup133 Psma2 Psma1 Ap2m1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Ap1m2 Psmb4 Ap1m1 Psmb7 Pacs1 Psmb6 Psmb1 Ap1s3 Ap2a2 Psmb3 Ap1s2 Ap1b1 Psmb2 Ap2a1 Ap1s1 Ap1g1 B2m Npm1 H2-Q10 Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Ap2b1 Psmd7 Ap2s1 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Cul5 Nup62 Nup88 Kpna1 Aaas Nup214 Banf1 Nup210 Nup155 Nup153 Slc25a5 Psip1 Slc25a4 Hmga1 Rcc1 Ranbp1 Cd28 Rac1 Kpnb1 Pak2 Arf1 Ran Nup37 Nup160 Nup43 Lck Ranbp2 Cd4 Fyn Atp6v1h Nup107 Xpo1 Nup85 Elmo1 Cdk9 Hck Cd8b1 Ccnt1 Sec13 Eloc Dock2 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins Hpgd Alox5 Lta4h Alox15 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 96%6802953 RAS signaling downstream of NF1 loss-of-function variants Spred1 Spred3 Spred2 Nras Nf1 Hras EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Eif2b3 Eif2b2 Rpl39l Eif2b5 Rps15a Eif2b4 Eif2s3x Eif2b1 Eif2s2 Eif2s1 Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Eif4ebp1 Eif4g1 Eif3m Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Pabpc1 Eif3g Eif3b Eif3a Eif3d Eif3c Eif4h Eif3j2 Eif4b Eif4e Eif1ax Eif4a2 Eif4a1 Rps27 Rps14 Rpl4 Eif5b Rps16 Eif5 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME%R-HSA-168274.5 Export of Viral Ribonucleoproteins from Nucleus Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Hspa1a Nup155 Nup153 Ran Xpo1 Nup85 Nup37 Sec13 Nup160 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399719 Trafficking of AMPA receptors Cacng8 Cacng4 Cacng2 Gria2 Cacng3 Dlg1 Grip2 Dlg4 Nsf Prkca Gria4 Gria3 Prkcg Akap5 Gria1 Myo6 Pick1 Ap2a1 Prkcb Tspan7 Camk2g Camk2d Mdm2 Camk2b Grip1 Camk2a DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor Vwf F8 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 96%6791465 Pentose phosphate pathway disease Taldo1 Rpia SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 96%69052 Switching of origins to a post-replicative state Psma4 Psma3 Psma6 Psma5 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdc27 Skp1 Ube2d1 Psmb5 Cdc16 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Ccne1 Psmb2 Ccne2 Fzr1 Skp2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Mcm7 Psmc1 Psmc4 Psmc3 Mcm3 Ubc Cdk2 Mcm4 Ccna1 Mcm5 Psmd7 Ccna2 Mcm6 Psmd6 Mcm2 Psmd8 Cdt1 Psmd3 Psmd2 Gmnn Psmd1 Adrm1 Sem1 Cul1 Cdc6 Orc5 Orc4 Orc6 Orc1 Mcm8 Orc3 Orc2 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%901042 Calnexin calreticulin cycle Ganab Canx Sel1l Edem2 Rnf5 Syvn1 Ubc Rnf103 Amfr Rnf139 Man1b1 Marchf6 Trim13 Uggt1 Edem1 Prkcsh Calr Uggt2 Pdia3 Os9 Edem3 Rnf185 Derl2 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME%R-HSA-9927418.2 Developmental Lineage of Mammary Gland Luminal Epithelial Cells Egf Tgfa Areg MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis Ago4 Ago3 Ago2 Ago1 Ran Polr2c Polr2d Polr2a Dgcr8 Polr2b Prkra Polr2g Polr2h Dicer1 Polr2e Tarbp2 Polr2f Polr2k Bcdin3d Polr2i Drosha Polr2j Xpo5 NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 96%9032759 NTRK2 activates RAC1 Rac1 Bdnf Ntrk2 Dock3 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9678110 Attachment and Entry Ace2 Tmprss2 Vcp DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema F12 Klkb1 Serping1 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73857 RNA Polymerase II Transcription Nfatc2 Prdx2 Jun Prdx1 Sod2 Cdk5r1 Bcl2l11 Ywhae Cdk5 Fasl Cdc25c Sympk Foxo3 Cstf1 Papola Clp1 Nudt21 Cpsf1 Cstf2 Cpsf2 Cstf3 Cpsf3 Cstf2t Wdr33 Notch1 Rbx1 Ihh Crh Gad1 Gad2 Cdc73 Rtf1 Leo1 Skic8 Ccne1 Ctr9 Ccne2 Paf1 Fzr1 Tfdp2 Tfdp1 Skp2 Rb1 Ccnd2 Ccnd3 Ccnd1 Cdk6 Cdk4 Cdk2 E2f1 Cdkn1a Daxx Cdkn1b Ppp2cb Ppp2ca Ppp2r1b Ppp2r1a Birc5 Aurkb Ppp2r5c Msh2 Pms2 Mlh1 Tjp1 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Rnmt Ercc3 Cdk7 Rngtt H2ac20 Prkaa1 Prkaa2 Myc Akt3 Akt2 Akt1 Tcf7l1 Tcf7l2 Mov10 Yes1 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 Ezh2 H2ax Csnk2a2 Tead4 Suz12 Ash2l Hist1h2bp Fos H2aj Yap1 Ctla4 H2bc9 H2bc7 H2bc8 H2bc3 Tead3 Tead2 Tead1 Stat1 Rictor H2ab2 H2bu2 Tcf7 Prkag3 Prkag1 Prkag2 Wwtr1 Kmt2c Hist2h2aa1 Prr5 Ywhag Pdpk1 Dpy30 Wdr5 Csnk2b Eed Gsk3b Mlst8 Lef1 H2bc14 Mtor Ptpn11 H2bc21 Tnrc6c H2bc26 Rbbp5 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Mapkap1 Prkab2 Prkab1 Ell Nelfa Nelfb Nelfe Taf15 Ctdp1 Taf11 Taf13 Taf12 Ccnk Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Taf9 Ncbp2 Ncbp1 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Taf8 Eloa Taf7 Taf6 Eloc Taf5 Taf4 Taf3 Taf2 Taf1 Trp53 Tgfb1 Cpsf4 Parp1 Pabpn1 Blk Elf1 Elf2 Cbfb Pax5 Sox2 Znf521 Trpc3 Prkcq Ywhah Hdac1 Sox9 Kit Ywhaz Pomc Cav1 Cga Cpsf7 Furin Rptor Ppm1a Slc38a9 Lamtor5 Lamtor4 Rraga Rragb Lamtor1 Rragc Lamtor2 Rragd Tsc2 Srrt Tsc1 Stk11 Nfyb Nfya Nfyc Gpam Sp1 Trp63 Tnfrsf10b Aff4 Supt6 Iws1 Mllt3 Mllt1 Eaf1 Itch Casp1 Stub1 Bax Fas Camk2g Camk2d Camk2b Camk2a Prkaca Cdkn2a Cdkn2b Ehmt2 Ehmt1 Txn Il6 Ring1 Cbx8 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Mdm2 Mdm4 Ccna1 Ccna2 Bmi1 Cebpb Map2k6 Rnf2 Mapkapk5 Bdnf Grin2b Jag1 Dll1 Snrpb Prmt5 Phax Snrpd3 Phf20 Pcbp4 Chek2 Zfp385a Snapc5 Snapc3 Snapc4 Snapc1 Snapc2 Znf143 Grin2a Camk4 Plk2 Gamt Myl12a Erbb2 Gls Itgbl1 Myb Zfp839 Cldn5 Ddit4 Ddit3 Txnip Med8 Retn Med4 Med6 Ell2 Lgals3 Ell3 Zfp825 Rprd1a Axin1 Rprd1b Gata3 Ints4 Gata4 Ints5 Pip4k2b Ints6 Gata1 Ints7 Gata2 Ints8 Pip4k2a Ints9 Higd1c Ints1 Cited4 Ints2 Cited1 Ints3 Cited2 Nabp1 Zfp819 Nabp2 Nfe2 Pou2f2 Plk3 IntS13 Cdc7 Ints14 Cdk13 Ints11 Cdk12 Ints12 Abca6 Ints10 mt-Co2 Zc3h8 mt-Co3 Rprd2 Gatad2a Rpap2 Junb Ice1 Gatad2b Ice2 Ret Ssu72 Gpi Btg2 Btg1 Chm Zfp872 Gli3 Gli2 Ing5 Ing2 Rarb Zik1 Brd2 Ppard Zfp867 Zkscan16 Tal1 Wwox Gps2 Zfp616 Rybp Tcf12 Zfp612 Brd7 Zfp619 Pf4 Kat2b Rarg Fancd2 Kat2a Wwp1 Zfp605 Atad2 Zfp606 Atxn3 Socs3 Gprin1 Smyd2 Socs4 Trp53rkb Men1 Zfp30 Usp2 Zfp37 Usp7 Pvalb Gria2 Csf2 Zfp69 Sesn2 Coxfa4 Cnot11 Sesn3 Itga5 Tfap2c Tfap2d Csf1r Tfap2a Tfap2b Setd1b Steap3 Itga4 Setd1a Tfap2e Cnot10 Abl1 Brpf3 Brpf1 Npas4 Zfp51 Kat6a Cdk8 Bcl6 ZNF418 Znf354c Znf354b Zfp84 Sin3a Sin3b Tnks1bp1 Il2ra Itgal Lbr Zfp90 Zfp78 Gpx2 Hand2 Iqsec3 Skil Pink1 Gls2 Dgcr8 Ptpn4 Ptpn1 Cox7a1 Cox7a2 Rnf34 Atp1b4 Klf4 Pitx2 Pml Ins2 Nkx2-5 Zfp157 Zfp398 Cox7a2l Zfp141 Cnot6l Actl6a Actl6b Smarce1 Apaf1 Rffl Znf382 Cradd Pidd1 Havcr2 Rnf111 Znf394 Tpx2 Tmem219 Zfp369 Banp Esrra Fanci Pbrm1 Esrrb Esrrg Fancc Zfp180 Zfp189 Zfp184 Fkbp5 Sgk1 Ccng2 Znf2 Zfp175 Pou2f1 Znf583 Npy Vegfa Satb2 Zfp169 Lifr Zfp791 Zfp790 Zfp317 Zfp558 Zfp799 Lmo2 Lmo1 Zfp300 Zfp786 Ube2d3 Znf569 Nop2 Arid2 Znf775 Zfp777 Nedd4l Yeats4 Fbxo32 Cbx5 Cbx3 Irak1 Znf551 Esr2 Zfhx3 Zfp764 Auts2 Jmy Ndrg1 Zfp111 Zfp597 Zfp113 Zfp112 Ybx1 Znf750 Tgif1 Tgif2 Ifng Kcnip3 Nr1d2 Kctd15 Mybl2 Znf771 Kdm5b Znf770 Rbl2 Itga2b Trim63 Dyrk2 Trp53inp1 Rbl1 Aurka Trim28 Zfp334 Hes1 Thra Zfp563 Slbp Dek Lsm10 Trim33 Lsm11 Zfp560 Zfp566 Zfp324 Prdm1 Mdc1 Spi1 Nampt Zfp712 Znf710 Zfp711 Twist2 Znf18 Twist1 Zfp703 Zfp709 Zfp706 Zfp708 Zfp707 Maml1 Maml2 Hdac11 Hdac10 Sfn Rbpj L3mbtl2 Zfp354a L3mbtl1 Znf704 Med23 Med24 Med25 Med20 Ddb2 Zscan25 Hey2 Hey1 Med26 Med27 Med12 Mmp13 Med13 Med14 Med10 Zfp740 Rspo3 Zfp746 Usp9x Med15 Med16 Krba1 Med17 Ncor2 Aifm2 Htt Zfp735 Pcgf6 Pcgf2 Pcgf5 Spp1 Bid Mbd3 Ucma Yy1 Ski Tigar Tnfrsf18 Hipk1 Hipk2 Srebf1 Mamld1 Cox6a1 Cox6a2 Rabggta Rabggtb Agrp Arid1a Arid1b Ppp1r13l Serpinb13 Kmt5a Egfr Ppp1r13b Maf Serpine1 Max Dlx5 Rgcc Sp7 Cpap Cnot3 Cnot2 Cnot1 Cnot7 Cnot6 Med30 Med31 Cnot4 Rorc Cnot9 Cnot8 Rorb G6pc1 Kmt2d Cox6b1 Cox6b2 Kmt2b Pin1 Trp53bp2 Rrm2b Syt10 Hivep3 Hdac2 Hdac5 Smarcb1 Foxg1 Slc2a3 Hdac7 Hdac6 Yaf2 Hdac9 Hdac8 Mobp Smarca2 Triap1 Smarca4 Nrbp1 Srf Arnt Prelid3a Smarcd1 G6pdx Smarcd2 Mga Pten Tbx5 Sst Smarcc2 Smarcc1 Nlrc4 Ppm1d E2f4 E2f5 E2f6 E2f7 E2f8 Uxt Rbfox1 Rbfox3 Epc1 Ccn2 Col1a2 Col1a1 Zfp2 Zfp1 Ccnc Zfp266 Zfpm1 Thbs1 Zfp9 Znf263 Pck1 Pip4p1 Cox8a Zfp248 Apoe Nuak1 Hnf4a Ctsk Ctsl Prmt6 Cox7b Prmt1 Hnf4g Psma4 Foxo4 Gp1ba Psma3 Bcl2l14 Psma6 Foxo1 Psma5 Zkscan8 Psma2 Tgfa Psma1 Zkscan1 Znf250 Zkscan4 Psmd12 Zkscan5 Psmd11 Znf496 Psmd14 Zkscan3 Psmd13 Bnip3l Nfkb1 Smurf2 Skp1 Smurf1 Foxp3 Psmb5 Nr4a3 Psmb4 Nr4a1 Psmb7 Zfp27 Psmb6 Zfp28 Psmb1 Runx3 Psmb3 Cox5a Psmb2 Zfp11 Zfp12 Zfp13 Rela Npm1 Prkcb Zfp14 Mstn Psma7 Zfp287 Psmc6 Zfp286 Psmc5 Ppargc1b Psmc2 Zfp282 Psmc1 Gck Psmc4 Ttc5 Psmc3 Kctd6 Ubc Nr2c2 Kctd1 Psmd7 Znf436 Psmd6 Zfp677 Pou4f1 Pou4f2 Psmd8 Msx2 Psmd3 Plxna4 Psmd2 Znf692 Psmd1 Gem Zfp426 Adrm1 Rxrb Sem1 Znf689 Cul1 Zfp664 Perp Oprm1 Sirt3 Trp73 Nr3c1 Rxrg Thrb Il2 Nr2c1 Zfp655 Vdr Smad1 Smad2 Nr1h2 Bmp2 Rora Smad3 Ppara Smad4 Esr1 Znf667 Pparg Nppa Znf668 Tcf3 Ar Smad6 Rxra Smad7 Hdac4 Ldb1 Ube2i mt-Co1 Rara Zfp473 Pgr Txnrd1 Nr5a1 Zfp235 Meaf6 Nr4a2 Cox4i1 Kat5 Cox4i2 Exo1 Hspd1 Nr2f6 Nr0b2 Nbn Nr2f1 Znf641 Rfc5 Notch4 Rbm14 Prelid1 Rfc3 Chd3 Pcna Chd4 Rfc4 Notch2 Cat Notch3 Rfc2 Nr2e1 Nkx3-2 Gadd45a Hus1 Zfp454 Atrip Zfp212 Brip1 Zfp691 Dna2 Igfbp3 Rest Zfp213 Rad51d Zfp697 Igfbp1 Blm Zfp458 Kras Chek1 Mta2 Rrm2 Rad9a Casp6 Bard1 Casp2 Rad9b Nr2c2ap Top3a Zfp445 Zfp202 Wrn Zfp688 Mre11a Zfp446 Oprk1 Rad51 Rad50 Rpa1 Topbp1 Rpa2 Rad17 Rbbp8 Brca1 Rpa3 Rad1 Atm Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdk1 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Src Ctnnb1 Fip1l1 Met Mapk1 Mapk3 Ywhab Mapk14 Mapk11 Ncor1 Atf2 Carm1 Ep300 Tbl1x Bmal1 Hdac3 Xpo1 Tbl1xr1 Smarcd3 Med1 Nr1d1 Ppargc1a Crebbp Mef2c Sirt1 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9865881 Complex III assembly Uqcc3 Uqcrb Uqcc1 Uqcc6 Uqcr10 mt-Cytb Fxn Bcs1l Ttc19 Uqcrh Hspa9 Letm1 Cyc1 Uqcrq Lyrm7 Hscb Uqcrc2 Uqcrc1 Lyrm4 Uqcrfs1 Uqcc2 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 96%5218921 VEGFR2 mediated cell proliferation Sphk1 Itpr3 Prkcb Prkcd Itpr2 Rasa1 Nras Itpr1 Plcg1 Prkca Hras Ahcyl1 Kdr Prkcz Pdpk1 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9608287 Defective MUTYH substrate binding SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR Rasgrp1 Adora2b Ppp3r1 Ppp3ca Ppp3cb C3ar1 App Prkx S1pr1 Cdk5 Btk Prkacb Adcy3 Adcy4 Adcy1 Ucn Sct Adcy2 Adcy7 Ihh Adm Adcy8 Adcy5 Adcyap1 Adcy6 Ramp1 Shh Gnaz Wnt5a Wnt9a Adcy9 Iapp Wnt9b Ucn3 Fzd10 Wnt10a Crhr1 Wnt10b Gnai2 Crhbp Gnai1 Gipr Gnai3 Gip Calcrl Prkar1b Smo Glp1r Crh Pth1r Wnt8b Gnat3 Wnt8a Prkar2b Cysltr2 Wnt16 Cysltr1 Wnt11 Calcr Ghrhr Adgre5 Gng10 Pth Dhh Adgre1 Gcgr Pth2 Glp2r Wnt6 Vipr2 Calca Vipr1 Gng3 Gng2 Ptch2 Ptch1 Gng4 Wnt7b Plcb4 Gng7 Ghrh Wnt3a Gng8 Pth2r Wnt7a Wnt2 Pthlh Wnt1 Wnt4 Wnt3 Fzd1 Gngt1 Gngt2 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Camk2g Fzd9 Fzd8 Camk2d Ahcyl1 Gcg Adcyap1r1 Camk2b Wnt2b Camk2a Ramp3 Ramp2 Gnb2 Adm2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Vip Gng12 Gng13 Prkaca Ccl12 Itpr3 Itpr2 Camkk1 Itpr1 Camkk2 Mapk7 Prkcg Arhgef9 Gnal Rasgrf2 Gabbr1 Gabbr2 Rps6ka3 Rps6ka2 Ppp2cb Ppp2ca Tiam1 Rho Gnat1 Ppp2r1b Ppp2r1a Saa3 C3 Ppp2r5d C5 Avpr2 Sstr3 Oxtr Avpr1b Avpr1a Oxt Avp Plcb3 Plcb2 Plcb1 Prkca Gnat2 Akt3 Akt2 Akt1 Prkar1a Mchr1 Adora2a Camk4 Pdyn Galr2 Galr3 Galr1 Fpr1 Tas1r2 Tas1r1 Tas1r3 Pnoc Tas2r131 Tas2r135 Tas2r137 Tas2r136 Gpr18 Tas2r140 Gpbar1 Tas2r4 Fpr-s1 Ptger4 Ccr5 Tas2r7 Ptger2 Ptger3 Mtnr1a Mtnr1b Agtr2 Vav1 Gpha2 Gpr37 Gpr35 Pik3r5 Pik3r6 Gpr31 Pik3r1 Rgr Pik3r2 Ccl17 Ccl11 Ptgdr2 Cx3cl1 Ccl28 Ccl25 P2ry13 Ccl22 Pak1 P2ry12 Ccl20 Gpr55 P2ry14 Lhcgr Oxgr1 Sucnr1 Prlhr Ece1 Psap Ccl7 P2ry4 Ccl5 Ccl4 Ccl3 Ccl2 Ccl1 Mrgprd Rrh Ptgdr Apln Tas2r39 Oprd1 Tas2r38 Cmklr1 Sstr5 Sstr4 Kel Sstr2 Sstr1 Gpr183 Lhb Ppbp Ccr10 Nln Tas2r16 Cx3cr1 Tas2r13 Ppy Gpr15 Ccr1 Pik3cg Gpr25 Npbwr1 Gpr27 Fshb Gpr20 Mc2r Gpr45 Fshr Pf4 Gpr84 Ccr9 Gpr83 Ccr8 Pik3ca Pde10a Ccr7 Pde11a Ccr6 Gpr176 Ccr4 Ccr3 Gpr150 Ccr2 Pde7b Crhr2 Plppr1 Pde7a Gal Rgs8 Plppr4 Pde8a Plppr5 Pde8b Plppr2 Pcp2 Pdpk1 Plppr3 Grk6 Penk Gpsm3 Npb Gpsm2 Opn1mw Gpsm1 Npw Pde3a Mas1 Ppp1r1b Tas2r40 Pde2a Tas2r41 Pde4a Hcar1 Rgs20 Hcar2 Rgs22 Cxcr1 Rgs14 Cxcr2 Pde4c Npy1r Pde4d Cxcr3 Rgs10 Xk Rgs12 Cxcr5 Itga5 Cxcr6 Oprl1 Prlh Rhoa Cxcl11 Hebp1 Arhgef18 Cxcl10 Opn1sw Aplnr Opn3 Ccrl2 Gper1 Opn5 Pyy Adora1 Adora3 Cxcl16 Cxcl13 Mcf2l Tas2r119 Npy5r Grm3 Grm2 Grm4 Arhgef16 Grm7 Grm8 Npy4r Ptgir Tas2r120 Tshr Cxcl9 S1pr3 Cxcl1 S1pr2 S1pr5 Cxcl2 S1pr4 Cxcl3 Cxcl5 Arhgef26 Tas2r107 Itsn1 Gpr37l1 Npy2r Itgb1 Ackr3 Ackr4 Cnr1 Kalrn Ackr1 Ackr2 Cnr2 Cort Prex1 Trio Anxa1 Mcf2 Rgs9 Rgs6 Rgs7 Mgll Ppp1ca Npy Gna11 Gna15 Gna14 Gnaq Cxcr4 Cxcl12 Ednra Rgs11 Npff Trhr Rgsl1 Gnrh1 Nmbr Fpr2 Ptgfr Agtr1a Nmb Lpar6 Xcr1 Lpar5 Ppan Grpr Gpr17 Nms Nmu Cckar Nmur2 Sos2 Gnrhr Nmur1 Ntsr2 Ntsr1 Brs3 Ptger1 Gpr132 Edn2 Prkar2a Cckbr F2 Hcrt Grp Kiss1r Nps Ptafr Npffr1 Npffr2 Gprc6a Prok2 Gpr4 Qrfp Prok1 Npsr1 Agt P2ry10 F2rl1 Gast F2rl2 F2rl3 Prokr2 Ghsr Prokr1 Rgs4 Rgs5 Rgs2 Rgs3 Gpr65 Rgs1 Gpr68 Uts2 Tacr1 Tacr3 Tacr2 Casr F2r Ffar3 Ffar4 Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng2 Grk5 Tac3 Tac1 Opn4 Pmch Ltb4r1 Ltb4r2 Hbegf Trh Grm1 Grm5 Lpar4 Lpar3 Lpar2 Lpar1 Mmp3 Qrfpr Xcl1 Kiss1 Rgs21 Rgs17 Rgs18 P2ry6 Rgs19 Rgs13 P2ry2 Rgs16 P2ry1 Hcrtr2 Hcrtr1 Uts2b Cck Uts2r Egfr Adra2a Adra2c Adra2b Pde3b Pla2g4a Grk2 Pde1b Pde1c Prkcd Sst Pde1a C5ar2 C5ar1 Trpc6 Trpc7 Trpc3 Grk3 Prkcb Prkcq Oprm1 Rasgrp2 Ednrb Daglb Dgka Dgkb Edn1 Abhd6 Edn3 Dgke Abhd12 Dgkg Dgkh Dgki Mc1r Dgkk Rps6ka1 Dgkq Prkch Dgkz Mc5r Dagla Prkce Rxfp3 Rln3 Rxfp2 Rxfp1 Mc4r Rln1 Pomc Insl3 Rxfp4 Insl5 Rhob Arhgef17 Arhgef11 Arhgef10 Mc3r Akap13 Arhgef25 Arhgef3 Arhgef2 Oprk1 Cga Arhgef1 Ect2 Tshb Arrb2 Vav3 Arrb1 Net1 Arhgef10l Vav2 Tiam2 Rhoc Plxnb1 Arhgef15 Arhgef19 Ngef Adra1b Adra1a Adra1d Gna12 Arhgef7 Arhgef6 Tbxa2r Arhgef4 Gna13 Fgd2 Fgd1 Fgd4 Arhgef37 Fgd3 Arhgef39 Arhgef38 Arhgef40 Plekhg5 Src Plekhg2 Rock2 Rock1 Mapk1 Mapk3 Gpr143 Htr4 Chrm1 Hrh1 Chrm3 Htr6 Chrm2 Htr7 Chrm5 Hrh4 Chrm4 Hrh2 Hrh3 Htr2a Nras Htr2c Htr2b Drd1 Adrb2 Drd2 Sos1 Adrb1 Drd3 Hras Abr Drd4 Drd5 Adrb3 Taar8b Htr1d Taar6 Htr1f Taar9 Taar2 Taar5 Htr1b Htr1a Taar1 Htr5a Ppp3cc DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 96%5579031 Defective ACTH causes obesity and POMCD Pomc Mc2r ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 96%2426168 Activation of gene expression by SREBF (SREBP) Sp1 Cyp51a1 Elovl6 Dhcr7 Srebf2 Ppara Rxra Helz2 Carm1 Tbl1x Fdft1 Ggps1 Sc5d Scd1 Ncoa2 Ncoa1 Lss Tm7sf2 Tbl1xr1 Smarcd3 Pmvk Mtf1 Ncoa6 Mvd Acacb Acaca Fdps Idi1 Med1 Mvk Nfyb Nfya Nfyc Crebbp Fasn Sqle Chd9 Gpam NUCLEOTIDE CATABOLISM DEFECTS%REACTOME%R-HSA-9735786.3 Nucleotide catabolism defects Pnp NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 Rnf135 Trim25 Mavs Ikbkg Rigi Casp8 Ikbkb Ripk1 Chuk Ifih1 Fadd MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.2 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Med27 Med12 Med13 Med14 Med10 H2bc9 Havcr2 H2bc7 H2bc8 H2bc3 Med16 Angptl4 Med17 Ncor2 Plin1 Mgll Cdk5 H2ab2 Kdm6a Fabp4 Pex11a H2bu2 Ncoa3 Lpin1 Elovl5 Cidec Nr5a2 Dgat2 Gps2 Rb1 Ppargc1b Lipe Plin4 Acsl1 Lpl Pnpla2 Thrsp Kmt2c Phlda1 Hist2h2aa1 Dpy30 Agpat2 Wdr5 Med30 Med31 Adipoq Kmt2d H2bc14 H2ac20 Rxra Cd36 H2bc21 H2bc26 Pagr1a Rbbp5 Ncor1 Abl1 Paxip1 Ep300 Cdk8 Tbl1x Ajuba Cebpa H2ac12 H2ac11 Plin2 Hdac3 Scd1 H2ac15 Ncoa2 H3c7 Ncoa1 H2ax Tbl1xr1 Ncoa6 Ash2l Hist1h2bp Med1 H2aj Ppargc1a Pdk4 Ccnc Crebbp Med23 Med4 Med24 Med6 Med20 Sirt1 Gpam SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%2408522 Selenoamino acid metabolism Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Cth Rps21 Rpl39l Rps15a Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Hnmt Rpl11 Rps3 Rps4x Papss2 Papss1 Ahcy Nnmt Mat1a Lars1 Eef1e1 Inmt Eefsec Gnmt Kars1 Scly Sars1 Sepsecs Sephs2 Secisbp2 Txnrd1 Pstk Rps27 Mars1 Dars1 Qars1 Rars1 Aimp2 Aimp1 Eprs1 Iars1 Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 Cbs BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins Alox5 Alox15 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 96%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) Slc36a2 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway G6pdx Rbks Dera Tkt Prps1l1 Prps1 Prps2 Pgls Shpk Rpe Taldo1 Rpia Pgd Pgm2 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated Ppp2cb Ppp2ca Gsk3b Ctnnb1 Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis Sel1l Psma4 Rnf5 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Erlin2 Psmd11 Erlin1 Psmd14 Psmd13 Rnf185 Derl3 Psmb5 Psmb4 Derl2 Psmb7 Derl1 Psmb6 Psmb1 Cftr Psmb3 Psmb2 Vcp Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Erlec1 Psmd3 Psmd2 Psmd1 Os9 Adrm1 Sem1 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 96%159418 Recycling of bile acids and salts Slco1b2 Ncoa2 Ncoa1 Abcb11 Slco1a4 Abcc3 Rxra Slc10a2 Slc10a1 Stard5 Nr1h4 Slc27a5 Baat Slc51a Alb Slc51b Fabp6 SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.5 Signaling by RAS mutants Arrb1 Jak2 Fgb Fga Rap1b Map2k2 Ksr1 Vwf Cnksr2 Nras Cnksr1 Fgg Map2k1 Araf Mark3 Itgb3 Pebp1 Raf1 Hras Tln1 Map3k11 Fn1 Vcl Csk Itga2b Src Camk2g Camk2d Camk2b Kras Camk2a Mapk1 Braf Mapk3 Ywhab Rap1a Brap Phb1 Apbb1ip Arrb2 Iqgap1 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 96%5218920 VEGFR2 mediated vascular permeability Cdh5 Jup Them4 Pak1 Vav2 Mlst8 Pak3 Pak2 Mtor Trib3 Nos3 Akt3 Akt2 Akt1 Rictor Mapkap1 Ctnnb1 Ctnnd1 Rac1 Cav1 Vav1 Prr5 Ctnna1 Pdpk1 Hsp90aa1 Vav3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5607761 Dectin-1 mediated noncanonical NF-kB signaling Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Relb Uba3 Psmd12 Psmd11 Map3k14 Psmd14 Psmd13 Skp1 Psmb5 Ube2m Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Nfkb2 Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Chuk RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013149 RAC1 GTPase cycle Arhgap32 Ykt6 Pak4 Prex1 Arhgap35 Trio Mcf2 Esyt1 Plekhg3 Mpp7 Ktn1 Srgap1 Srgap2 Cyfip1 Srgap3 Wipf3 Tmpo Arhgap39 Wipf2 Wipf1 Cyfip2 Pld2 Slc1a5 Dock7 Was Wasf3 Abl2 Wasl Sos2 Nisch Pak6 Myo9b Pak5 Cdc42bpa Dock8 Arhgef11 Arhgef10 Iqgap3 Rac1 Cav1 Cit Arhgef25 Vav1 Pik3r1 Pik3r2 Ect2 Vav3 Iqgap1 Pak1 Vav2 Pak3 Dlc1 Pak2 Pkn2 Pkn1 Tiam2 Arhgef15 Arhgef19 Ngef Arhgap4 Arap1 Arhgap9 Arhgef7 Gmip Arhgef6 Arhgef4 Gna13 Def6 Rasgrf2 Fgd5 Arhgef39 Arhgap12 Plekhg2 Arhgap22 Arhgap20 Arhgap25 Arhgap24 Arhgap23 Arhgap29 Arhgap33 Pik3ca Arhgap31 Arhgap30 Dock11 Plekhg6 Plekhg4 Plekhg1 Ralbp1 Ncf1 Ncf2 Arhgap44 Arhgap45 Ncf4 Brk1 Swap70 Farp2 Amigo2 Noxa1 Tfrc Git1 Baiap2 Arhgap15 Arhgap17 Fam13b Nckap1l Tiam1 Fermt2 Bcr Farp1 Lamtor1 Arap3 Pard6a Arap2 Sos1 Baiap2l1 Arhgap26 Cdc42ep4 Dock3 Syde2 Abr Nckap1 Arhgef18 Nhs Git2 Wasf2 Wasf1 Noxo1 Spata13 Dock10 Racgap1 Taok3 Snap23 Mcf2l Cyba Rab7 Dock6 Jag1 Als2 Abi2 Arhgdib Abi1 Cybb Arhgdia Garre1 Nox3 Arhgap42 Nox1 Fmnl1 Erbin Emd Sh3bp1 Lemd3 Iqgap2 Lbr Diaph3 Cdc42ep1 Depdc1b Vrk2 Vamp3 Epha2 Dock5 Arhgap5 Itgb1 Dock4 Arhgap1 Arhgap10 Kalrn Arhgap21 Vangl1 Mcam Ophn1 Pld1 Dock1 Dock2 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 96%5579013 Defective CYP7B1 causes SPG5A and CBAS3 Cyp7b1 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69275 G2 M Transition Nedd1 Actr1a Tuba1a Psma4 Tpx2 Psma3 Dctn2 Psma6 Dctn3 Psma5 Psma2 Psma1 Psmd12 Psmd11 Ywhae Psmd14 Cenpf Psmd13 Optn Ppp1cb Skp1 Cdc25c Psmb5 Psmb4 Cdc25b Psmb7 Cdc25a Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Pcnt Tuba4a Btrc Rbx1 Cep250 Psma7 Sdccag8 Psmc6 Cep78 Psmc5 Psmc2 Psmc1 Cep76 Psmc4 Psmc3 Cep72 Ubc Cep70 Psmd7 Fkbpl Psmd6 Tubb5 Ppp2r2a Gtse1 Plk4 Phlda1 Psmd8 Psmd3 Psmd2 Mnat1 Psmd1 Adrm1 Sem1 Cul1 Cep135 Mis18bp1 Cep131 Trp53 Prkar2b Ccnh Cdk7 Tubb4b Haus7 Tubb4a Haus8 Cdk5rap2 Mybl2 Fbxl7 Cep57 Pcm1 Aurka Ssna1 Tubg1 Ofd1 Cep63 Cep152 Haus3 Haus4 Haus5 Haus6 Sfi1 Csnk1d Haus1 Haus2 Hsp90aa1 Cep164 Prkaca Ccp110 Alms1 Cetn2 Tubgcp2 Rab8a Tubg2 Nme7 Tubgcp5 Tubgcp4 Fbxl18 Tubgcp3 Cep43 Mzt1 Mzt2 Cep41 Ppp1r12a Plk1 Ninl Cdk1 Nek2 Pkmyt1 Hsp90ab1 Fzr1 Cdk2 Ccna1 Ccna2 Lin54 Cdkn1a Lin9 Cpap Wee1 Clasp1 Lin37 Ywhag Pafah1b1 Ppp2cb Ppp2ca Sgo1 Csnk1e Foxm1 Mapre1 Rbbp4 Dynll1 Lcmt1 Obi1 Bora Ppme1 Ep300 Ticrr Ppp2r1b Cdk11b Ajuba Ppp2r1a Dync1h1 Hmmr Xpo1 Ccnb2 Dync1i2 Ckap5 Akap9 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs Ncbp2 Ncbp1 Zfp473 Snrpb Lsm10 Lsm11 Snrpd3 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 96%5663220 RHO GTPases Activate Formins Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Cenpo Cenpn Cenpm Srgap2 Mis12 Nup133 Cenpl Zwilch Cenpk Cenpi Cenph Cenpf Cenpe Dvl1 Dvl2 Dvl3 Actb Mrtfa Pfn1 Pfn2 Evl Rhob Fmnl3 Diaph1 Daam1 Rac1 Rhoc Plk1 Actg1 Clasp1 Clasp2 Pafah1b1 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Rhod Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Kif2b Kif2c Dync1li2 Pmf1 Rhoa Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Srf Ppp2r1b Ppp2r1a Scai Fmnl2 Ndc80 Fmnl1 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Diaph3 Ercc6l Xpo1 Nuf2 Nup85 Cdca8 Incenp Dync1i2 Ndel1 Itgb1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B Anapc15 Ubc Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdk1 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Cdc20 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 96%8978934 Metabolism of cofactors Gch1 Idh1 Pdss2 Coq8a Coq8b Pdss1 Coq2 Coq3 Pts Gchfr Coq4 Coq5 Coq6 Hpdl Prkg2 Coq7 Spr Coq9 Stard7 Nos3 Akt1 Dhfr Hsp90aa1 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 96%9635486 Infection with Mycobacterium tuberculosis Nos2 Gsk3a Pgk1 Sfpq Coro1a B2m Ctsg Vps33b Rab5a Rnf213 Hgs Mrc1 Ltf Dusp16 Trim27 Ubc Atp6v1h Mapk1 EG433182 Mapk3 Kpna1 Kpnb1 Tlr2 Rab7 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576890 Phase 3 - rapid repolarisation Kcne5 Kcna5 Kcne4 Kcne3 Kcne2 Kcne1 Akap9 Kcnh2 Kcnq1 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion Pak1 Pak3 Pak2 Nrp1 Limk1 Sema3a Fyn Rac1 Plxna1 Plxna4 Plxna3 Hsp90aa1 Cfl1 Plxna2 Fes Hsp90ab1 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190372 FGFR3c ligand binding and activation Fgf16 Fgf23 Fgf18 Fgf2 Fgf1 Fgf4 Galnt3 Fgf9 Fgf20 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 96%195258 RHO GTPase Effectors Mylk Myl6 Dlg4 Ktn1 Cyfip1 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Ywhae Btk Kdm1a Ppp1cb Dvl1 Cdc25c Dvl2 Dvl3 Actb Arpc3 Arpc2 Cyfip2 Arpc5 Arpc4 Mrtfa Ptk2 Nckipsd Pfn1 Was Wasf3 Pfn2 Wasl Nck1 Evl Fmnl3 Sfn Ppp1r12b Ppp1r12a Ppp1r14a Lin7b Gopc Cdkn1b Clasp1 Clasp2 Pafah1b1 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Rhod Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Pik3c3 Sgo1 Ranbp2 Bub1b Kif2a Pin1 Kif2b Kif2c Dync1li2 Pmf1 Ska1 Dync1li1 Rhpn1 Ahctf1 Nup107 Dsn1 Pik3r4 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Srf Ppp2r1b Ppp2r1a Fmnl2 Ndc80 Fmnl1 Kif18a Nudc Dync1h1 Prkcd Birc5 Spc24 Spc25 Ercc6l Nuf2 Nup85 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 Cfl1 B9d2 Bub3 Bub1 Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Cenpo Cenpn Cenpm Mis12 Srgap2 Nup133 Cenpl Zwilch Cenpk Cenpi Cenph Cenpf Cenpe Cttn Prkcb Kif14 Kdm4c Prkca H2ac20 Ywhah Ar Ywhaz Cftr H2ac12 H2ac11 H2ac15 Klc1 H3c7 Rhob Klc4 Klc3 H2ax Klc2 Myh9 Myl12a Iqgap3 Diaph1 Daam1 Rac1 Hist1h2bp Cit H2aj Pkn3 Rtkn Iqgap1 Rhpn2 Pak1 Pak3 Pak2 Pkn2 H2bc9 Pkn1 H2bc7 Rhoc H2bc8 H2bc3 Plk1 Rac2 S100a9 S100a8 H2ab2 Actg1 H2bu2 Rock2 Ctnnb1 Rock1 Myh14 Myh10 Cdh1 Limk1 Limk2 Mapk1 Mapk3 Hist2h2aa1 Ywhab Ncf1 Ncf2 Ywhag Ncf4 Kif5b Pdpk1 Brk1 Mapk14 Men1 Noxa1 Baiap2 Nckap1l H2bc14 Rhoa Mapk11 Nckap1 Prkcz H2bc21 Wasf2 H2bc26 Wasf1 Noxo1 Abl1 Cyba Rhog Abi2 Abi1 Cybb Nox3 Scai Nox1 Iqgap2 Diaph3 Ncoa2 Xpo1 Myl12b Itgb1 Myh11 Ropn1 Ctnna1 Nf2 Prc1 Flna ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 96%2046106 alpha-linolenic acid (ALA) metabolism Acot8 Elovl3 Elovl5 Hsd17b4 Acaa1a Scp2 Abcd1 Elovl1 Acsl1 Fads2 Fads1 TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation Psen2 Ncstn Tgfbr3 Aph1b Mmp14 Mmp16 Timp1 Timp2 Psen1 TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism Ppp1cc Prkaca Fabp12 Lipe Gpd2 Fabp9 Plin3 Cav1 Pnpla5 Plin1 Abhd5 Mgll Ppp1ca Fabp1 Ppp1cb Fabp2 Fabp3 Fabp4 Prkacb Fabp5 Fabp6 Fabp7 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) Cd36 Itgav Itgb5 Ncf1 Ncf2 Ncf4 Cyba Cybb RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 96%177504 Retrograde neurotrophin signalling Ngf Ap2a2 Ap2a1 Ntrk1 Dnm2 Sh3gl2 Ap2b1 Ap2s1 Clta Ap2m1 Cltc Dnm1 Dnal4 Dnm3 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Tfap2b Ube2i Kctd1 Tfap2e Wwox Tfap2c Kctd15 Tfap2d Tfap2a SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-HSA-9006931.7 Signaling by Nuclear Receptors Sp1 Mmp9 Jun Angptl3 Plin1 Ebag9 Cxxc5 Tle3 Nr1h3 Kdm1a Greb1 Fkbp5 Ddx5 Ctsd Foxo3 Kdm4b Kank1 Fabp5 Abcg1 Pou2f1 Fabp6 Fkbp4 Mylip Chd1 Tff3 Zfp217 Foxa1 Sphk1 Ncoa3 Usf1 Usf2 Nr5a2 Apoc1 Apoc2 Ptk2 Abca1 Gnai2 Gnai1 Gnai3 Esr2 Apoc4 Gnat3 Cxcl12 Gng10 Gng3 Gng2 Gng4 Gng7 Gng8 Gngt1 Gngt2 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Hsp90aa1 Gng12 Gng13 Elk1 Ncor2 Ereg Hbegf Btc Epgn Uhmk1 Mmp3 Yy1 Aldh1a1 Cbfb Ccnd1 Egfr Cdkn1b Smc3 Fasn Rad21 Egf Bcl2 Areg Stag2 Stag1 Srf Mmp2 Pck1 Apoe Prmt1 Tgfa Smc1a Adh4 Adh1 Kctd6 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Rxrb Abcg8 Polr2j Abcg5 Gtf2f2 Gtf2f1 Dhrs4 Rxrg Nr1h2 Esr1 H2ac20 Rxra Hdac1 Myc Rara Nos3 Akt3 Pgr Akt2 Akt1 Kat5 Eepd1 Jund Strn Arl4c Kdm1b Kdm3a Apod Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 H2ax Pdhx Myb Hist1h2bp Cav1 Fos Pdha1 Pdha2 H2aj Pdk4 Pdk3 Pik3r1 Pik3r2 Pdk2 Pdk1 Pdhb Axin1 Gata3 Fosb Cited1 H2bc9 H2bc7 H2bc8 Dlat H2bc3 H2ab2 Hsp90ab1 Rarb H2bu2 Ppard Src Gps2 Igf1r Kat2b Pik3ca Rarg Mapk1 Mapk3 Hist2h2aa1 Pdpk1 Nras H2bc14 Hras Prkcz H2bc21 Tnrc6c H2bc26 Ncor1 Atf2 Tnrc6a Tnrc6b Carm1 Nrip1 Ep300 Dhrs3 Tbl1x Aldh1a2 Rdh11 Aldh1a3 Rdh10 Akr1c18 Aldh8a1 Rdh13 Rdh14 Ppp5c Hdac3 Cyp26b1 Dld Scd1 Kdm4a S1pr3 Cyp26c1 Ncoa2 Rdh16f2 Tbp Cyp26a1 Ncoa1 Xpo1 Rdh5 Gtf2a1 Crabp1 Tbl1xr1 Gtf2a2 Dhrs9 Sdr16c5 Med1 Cdk9 Zdhhc7 Ccnt1 Ugt1a2 Crebbp Crabp2 Zdhhc21 Ppid Cav2 Gpam Mmp7 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%1839124 FGFR1 mutant receptor activation Fgf2 Fgf1 Bcr Fgf4 Fgf6 Bag4 Stat5a Fgf9 Cep43 Stat5b Fgf20 Gab2 Fgf23 Fgfr1 Stat3 Erlin2 Stat1 Myo18a Cux1 Fgfr1op2 Cpsf6 Zmym2 Pik3ca Pik3r1 Trim24 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Rbbp8 Rtel1 Brca2 Brca1 Xrcc3 Rad51ap1 Xrcc2 Atm Kat5 Exo1 Nbn Brip1 Dna2 Rad51c Rad51d Blm Rad51b Bard1 Top3a Wrn Mre11a Palb2 Sem1 Rad51 Rad50 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes Pcolce Col4a1 Col24a1 P3h2 Col5a1 Colgalt1 P3h1 Col25a1 P3h3 Col4a2 Col9a2 Pcolce2 Col9a3 Crtap Colgalt2 Col6a6 Serpinh1 Col8a1 Col6a3 Plod3 Col4a5 Plod1 Col9a1 Plod2 Col8a2 Col4a6 Col20a1 Adamts3 Adamts2 Adamts14 Bmp1 Tll2 Tll1 P4hb Col15a1 Col16a1 Col17a1 Col18a1 Col11a1 Col12a1 Col11a2 Col13a1 Col14a1 Col19a1 Col10a1 Col2a1 Col26a1 Col3a1 Col1a2 Col27a1 Col28a1 Col1a1 Col22a1 Col6a1 Col5a2 Col4a3 Ppib Col23a1 Col7a1 Col6a2 P4ha1 Col5a3 P4ha2 Col4a4 P4ha3 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection Taf4 Taf3 Taf2 Taf1 Ppia Chmp2a Ap2m1 Chmp3 Chmp7 Chmp6 Ap2a2 Ap2a1 Chmp4c Rbx1 Chmp4b Ap2b1 Pdcd6ip Ap2s1 Nedd4l Cxcr4 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Lig1 Nup62 Nup88 Kpna1 Aaas Nup214 Banf1 Nup210 Nup155 Nup153 Slc25a5 Psip1 Slc25a4 Hmga1 Kpnb1 Arf1 Ran Fen1 Nup37 Nup160 Nup43 Ranbp2 Nup107 Nup85 Sec13 Psma4 Psma3 Psma6 Psma5 Xrcc6 Nup133 Psma2 Xrcc5 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Ap1m2 Psmb7 Ap1m1 Pacs1 Psmb6 Psmb1 Ap1s3 Psmb3 Ap1s2 Ap1b1 Psmb2 Ap1s1 Ap1g1 B2m Npm1 H2-Q10 Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Polr2c Polr2d Psmd7 Polr2a Psmd6 Polr2b Polr2g Polr2h Psmd8 Polr2e Psmd3 Polr2f Psmd2 Polr2k Mnat1 Psmd1 Polr2i Polr2j Adrm1 Gtf2h2 Sem1 Gtf2h1 Nmt2 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Rnmt Ercc3 Cdk7 Rngtt Cul5 Ubap1 Tsg101 Mvb12a Mvb12b Vps37a Vps37b Vps37c Rcc1 Vta1 Vps37d Ranbp1 Nmt1 Cd28 Ccr5 Chmp5 Vps28 Rac1 Vps4a Vps4b Pak2 Furin Lck Cd4 Fyn Atp6v1h Ell Lig4 Nelfa Nelfb Nelfe Taf15 Ctdp1 Xrcc4 Taf11 Taf13 Taf12 Ccnk Tbp Taf4b Xpo1 Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Taf9 Ncbp2 Ncbp1 Supt4h1a Tcea1 Nelfcd Supt16 Elmo1 Cdk9 Hck Ccnt2 Ssrp1 Cd8b1 Ccnt1 Taf8 Eloa Taf7 Taf6 Eloc Dock2 Taf5 DRUG RESISTANCE OF ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9700649 Drug resistance of ALK mutants Alk IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID Ikbkg Ikbkb Chuk NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 96%187024 NGF-independant TRKA activation Adcyap1r1 Ntrk1 Ntrk2 Adora2a Adcyap1 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling Fgf16 Frs2 Fgf15 Fgf18 Fgf2 Fgf1 Nras Fgf4 Frs3 Fgf6 Sos1 Fgf9 Hras Fgf20 Ptpn11 Fgf23 Fgfr4 Klb KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism Oxct2a Bdh1 Oxct1 Acat1 NUCLEOTIDE METABOLISM%REACTOME%R-HSA-15869.7 Nucleotide metabolism Impdh1 Gmps Nme2 Hprt1 Nme1 Samhd1 Entpd1 Guk1 Nt5e Entpd5 Cda Gda Entpd2 Umps Xdh Entpd6 Entpd3 Entpd7 Entpd8 Gart Cad Atic Dnph1 Adsl Pudp Txn Uckl1 Itpa Dhodh Adss2 Pfas Adss1 Ppat Tk2 Uck1 Uck2 Paics Nt5c2 Dtymk Dguok Nudt13 Gmpr Adk Rrm1 Ak1 Dck Nme3 Aprt Ak2 Adal Glrx Gmpr2 Pnp Ak5 Nme4 Ampd3 Ak7 Ampd2 Ampd1 Dctpp1 Dctd Ada Cmpk1 Ak8 Nme6 Ctps2 Ctps1 Rrm2b Nudt16 Txnrd1 Adprm Tymp Nudt5 Nt5c Tyms Nt5c1a Upb1 Tk1 Agxt2 Upp1 Upp2 Dpys Dpyd Nt5m Rrm2 Nudt15 CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation Eif2s3x Eif2s2 Eif2s1 Eif2ak4 Fnip1 Samtor Szt2 Itfg2 Gcn1 Nprl3 Nprl2 Wdr59 Mios Depdc5 Kptn Impact Castor1 Kics2 Wdr24 Flcn Sh3bp4 Trib3 Asns Atf3 Cebpg Rps14 Rpl4 Atf4 Rps16 Sesn1 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Ddit3 Rps11 Rpl7 Rpl32 Rps9 Rps7 Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Atp6v0b Rps4x Atp6v1g3 Atp6v0e2 Atp6v1c2 Atp6v1c1 Rptor Atp6v1e2 Atp6v1e1 Cebpb Tcirg1 Slc38a9 Atp6v1a Lamtor5 Atp6v1b2 Atp6v0d2 Lamtor4 Atp6v0d1 Rraga Atp6v1b1 Mlst8 Rragb Sesn2 Atp6v0e1 Atp6v1g2 Lamtor1 Atp6v1g1 Rragc Lamtor2 Rragd Atp6v1f Mtor Atp6v1d Atp6v1h Atf2 Rps27 Sec13 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%140534 Ligand-dependent caspase activation Tlr4 Casp8 Ripk1 Tradd Ticam2 Traf2 Fas Ticam1 Cd14 Fasl Ly96 Tnfsf10 Tnfrsf10b Fadd RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 96%8941856 RUNX3 regulates NOTCH signaling Kat2b Runx3 Maml1 Maml2 Kat2a Mamld1 Rbpj Notch1 Crebbp Hes1 Jag1 Ep300 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963896 HDL assembly Prkaca Abca1 Zdhhc8 Apoa1 Prkacb A2m INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters Slc2a13 Slc5a11 Slc5a3 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism Prelp Chst3 Chst2 Chst5 St3gal6 Galns Lum St3gal4 Hexa Hexb St3gal2 St3gal1 Omd Ogn Slc35d2 Glb1 Fmod Gns B4galt4 Glb1l3 B4galt5 Glb1l2 B4galt6 B4gat1 B4galt1 B4galt2 B4galt3 B3gnt3 B3gnt7 Kera B3gnt4 B3gnt2 Chst1 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 96%9937008 Mitochondrial mRNA modification Ngrn Fastkd2 Trub2 Rpusd4 Slirp Mtpap Mterf3 Lrpprc Rcc1l BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins Alox5 Lta4h PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%156580 Phase II - Conjugation of compounds Tpmt Ugp2 Gsta3 Gstm2 Ggt1 Sult1e1 Sult1a1 Abhd14b Sult1b1 Podxl2 Bpnt2 Sult6b1 Sult4a1 Sult2a1 Bpnt1 Ggt5 Cyp1a2 As3mt Ahcy Nnmt Mtrr Trmt112 Mat2a Gss Mtr Hemk2 Comt Gsto1 Mat2b Mat1a Tpst1 Ggt7 Tpst2 Ugt2a1 Ugt2a2 Acsm1 Ggt6 Ugt2a3 Ugt2b1 Mgst3 Mgst2 Ugdh Mgst1 Slc35d1 Ugt1a6 Ugt1a9 Uxs1 Gstk1 Ugt3a2 Ugt1a5 Abhd10 Ugt1a1 Nat1 Nat2 Ugt2b38 Ugt2b36 Ugt2b34 Slc35d2 Gstz1 Gsta5 Chac1 Chac2 Gstm7 Gstm5 Gstm4 Gstm1 Gsto2 Esd Glyatl3 Cndp2 Hpgds Acsm2 Gstt2 Acsm4 Gstt1 Acsm5 Glyat Oplah Akr1a1 Gclc Gclm Ugt1a2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%R-HSA-3656535.3 TGFBR1 LBD Mutants in Cancer Fkbp1a Tgfb1 Tgfbr1 Tgfbr2 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%9690406 Transcriptional regulation of testis differentiation Amh Zfpm2 Sox9 Gata4 Ptgds Nr5a1 Dhh Wt1 Fgf9 Dmrt1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-HSA-110313.3 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template Uba7 Rpa2 Rpa3 Polk Polh Pole Isg15 Sprtn Pclaf Usp43 Mad2l2 Rev1 Rev3l Usp10 Poli Rchy1 Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Trim25 Rfc1 Rfc2 Pold4 Vcp Pold3 Ufd1 Pole3 Nploc4 Pole2 Ubc Pole4 Ube2l6 Rpa1 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME DATABASE ID RELEASE 96%5336415 Uptake and function of diphtheria toxin Txnrd1 Hbegf Eef2 Hsp90aa1 Cd9 Hsp90ab1 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702998 linifanib-resistant FLT3 mutants Flt3 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 96%964739 N-glycan trimming and elongation in the cis-Golgi Mgat1 Man1a Man1a2 Man1c1 Manea INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 96%9014826 Interleukin-36 pathway Il36b Il1f10 Il36a Il36g Il36rn Il1rl2 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 96%2160456 Phenylketonuria Pah SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 96%1483191 Synthesis of PC Bche Chat Mfsd2a Phospho1 Pcyt1b Pcyt1a Abhd3 Slc44a3 Pemt Lpin3 Chpt1 Slc44a4 Pctp Slc44a5 Lpin2 Stard10 Lpin1 Cept1 Slc44a1 Chka Slc44a2 Chkb Csnk2a2 Stard7 Ache Lpcat1 Csnk2b FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190377 FGFR2b ligand binding and activation Fgf22 Fgfbp3 Fgfbp1 Fgf2 Fgf1 Fgf10 Fgf3 Fgf7 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9931269.1 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Sel1l Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Rnf185 Derl3 Psmb5 Psmb4 Derl2 Psmb7 Derl1 Psmb6 Psmb1 Psmb3 Psmb2 Vcp Psma7 Psmc6 Prkag3 Psmc5 Psmc2 Psmc1 Psmc4 Prkag1 Psmc3 Prkag2 Ubc Psmd7 Psmd6 Psmd8 Erlec1 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cd274 Rnf5 Prkaa1 Prkaa2 Erlin2 Erlin1 Prkab2 Prkab1 Os9 UNCOATING OF THE HIV VIRION%REACTOME%R-HSA-162585.3 Uncoating of the HIV Virion Ppia BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Ltc4s Gstm4 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 96%4793953 Defective B4GALT1 causes CDG-2d B4galt1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 96%5099900 WNT5A-dependent internalization of FZD4 Ap2a2 Ap2a1 Cltb Prkcb Prkca Fzd4 Prkcg Ap2b1 Wnt5a Ap2s1 Clta Ap2m1 Cltc Dvl2 Arrb2 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8939902.4 Regulation of RUNX2 expression and activity Psma4 Psma3 Psma6 Psma5 Psma2 Esrra Psma1 Psmd12 Stat1 Psmd11 Psmd14 Psmd13 Skp1 Smurf1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Skp2 Rbx1 Psma7 Psmc6 Psmc5 Ppargc1b Psmc2 Psmc1 Cbfb Psmc4 Psmc3 Stub1 Ubc Psmd7 Psmd6 Dlx5 Wwp1 Msx2 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Nr3c1 Gsk3b Bmp2 Esr1 Hivep3 Nkx3-2 Twist1 Ppargc1a DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME DATABASE ID RELEASE 96%9636383 Prevention of phagosomal-lysosomal fusion Coro1a Vps33b Rab5a Hgs Rab7 Ubc NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 96%194306 Neuropilin interactions with VEGF and VEGFR Flt1 Nrp1 Nrp2 Kdr ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation Nos3 Cav1 Akt1 Cygb Cyb5b Lypla1 Ddah1 Hsp90aa1 Zdhhc21 Nmt2 Spr Nmt1 TNF SIGNALING%REACTOME%R-HSA-75893.10 TNF signaling Rbck1 Ikbkb Birc3 Mib2 Birc2 Ikbkg Tradd Map3k7 Traf2 Ikbke Xiap Optn Ube2d1 Fadd Ube2l3 Casp8 Ulk1 Ripk1 Ube2d3 Stub1 Ubc Rack1 Mapkapk2 Chuk Usp2 Tab3 Tab2 Tab1 Sharpin Usp21 Traf1 Tnf Spata2 Rnf31 Tnfrsf1a Usp4 Bag4 Cyld Otud7b Tnfaip3 Tbk1 Adam17 Tax1bp1 Clip3 Smpd2 Smpd3 Nsmaf Sppl2b Otulin Sppl2a RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing Zdhhc9 Nras Golga7 Lypla1 Arl2 Prkg2 Hras Icmt Kras Bcl2l1 Abhd17b Abhd17a Abhd17c Rce1 Pde6d Fnta Fntb Prkcq DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 96%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) Gata3 Stat6 Nfatc2 Batf Ets1 Pou2f2 Il5 Stat5a Stat5b Jun Ncor2 Gatad2a Gatad2b Mbd3 Yy1 Pou2f1 Ring1 Cbx8 Phc2 Cbx6 Phc1 Mamld1 Cbx4 Mta1 Cbx2 Notch1 Mta3 Phc3 Kat2b Maf Kat2a Bmi1 Dpy30 Wdr5 Men1 Rnf2 Satb1 Il4 Il13 Irf4 Hdac2 Hdac1 Hdac5 Hdac4 Hdac7 Hdac6 Rbbp5 Hdac9 Rbbp4 Hdac8 Ncor1 Rbbp7 Smarca4 Ep300 Tbl1x Chd3 Chd4 Notch2 Hdac3 Tbl1xr1 Il4ra Ash2l Maml1 Mta2 Maml2 Hdac11 Hdac10 Fos Rbpj Klf13 Crebbp FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190374 FGFR1c and Klotho ligand binding and activation Fgf23 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.3 SUMO is proteolytically processed Senp1 Sumo3 Senp2 Senp5 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 96%8877627 Vitamin E transport Ttpa FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9617828 FOXO-mediated transcription of cell cycle genes Smad2 Gadd45a Mstn Smad3 Smad4 Foxo4 Foxo1 Rbl2 Foxg1 Cav1 Cdkn1a Cdkn1b Pcbp4 Klf4 Btg1 Ccng2 Foxo3 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation Vars2 Qars1 Ears2 Wars2 Aars2 Rars2 Pars2 Ppa2 Mars2 Dars2 Yars2 Sars2 Hars2 Fars2 Kars1 Gars1 Lars2 Nars2 Tars2 Iars2 Cars2 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9648895 Response of EIF2AK1 (HRI) to heme deficiency Cebpg Grb10 Eif2ak1 Trib3 Atf5 Atf4 Eif2s3x Asns Eif2s2 Eif2s1 Ddit3 Atf3 Chac1 Cebpb NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 96%9930044 Nuclear RNA decay Exosc10 Srrt Papolg Rbm26 Rbm27 Ythdc2 Zcchc8 Ythdc1 Zc3h18 Zfc3h1 Rbm7 Tent4b Dxo Wdr82 Xrn2 Pabpn1 Mphosph6 Ncbp2 Ncbp1 Exosc9 Exosc8 Mtrex Exosc5 Dis3 Exosc4 C1d Exosc7 Tent4a Exosc6 Exosc1 Exosc3 Exosc2 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 96%195399 VEGF binds to VEGFR leading to receptor dimerization Vegfd Vegfa Vegfc Vegfb Flt1 Pgf Flt4 Kdr PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 96%432142 Platelet sensitization by LDL Ppp2cb Ppp2ca Pla2g4a Pecam1 Ptpn6 Ppp2r5e Ptpn11 Fgr Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Mapk14 Ppp2r1b Ppp2r1a Apob REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME%R-HSA-9843970.1 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Mphosph8 H2bc3 H2bc21 Zcchc8 H2bc26 Ehmt2 Rbm7 H2ab2 Morc2a Ehmt1 Pphln1 H2bu2 Setdb1 H2ac12 H2ac11 Atf7ip H2ac15 H3c7 H2ax Mtrex Hist1h2bp Hist2h2aa1 H2aj P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%372708 p130Cas linkage to MAPK signaling for integrins Fgb Fga Src Rap1b Vwf Fgg Itgb3 Crk Tln1 Fn1 Bcar1 Itga2b Ptk2 Rap1a Apbb1ip INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion Cd36 Acsl3 Acsl4 MEIOTIC RECOMBINATION%REACTOME%R-HSA-912446.7 Meiotic recombination Rpa2 Rbbp8 Brca2 Brca1 H2bc14 H2bc9 Rpa3 H2bc7 H2ac20 H2bc8 Atm H2bc3 H2bc21 H2bc26 H2ab2 H3c8 Nbn Psmc3ip Mnd1 Mlh1 Mlh3 Spo11 H2bu2 Msh4 H2ac12 Dmc1 Fignl1 H2ac11 Msh5 Prdm9 H2ac15 H3c7 H2ax Rad51c Cdk4 Blm Cdk2 Hist1h2bp Hist2h2aa1 Top3a H2aj Mre11a Rad51 Rad50 Firrm Rpa1 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME DATABASE ID RELEASE 96%9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK Clock Bmal1 Cdk5 Csnk2b SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin Fst Acvr1c Drap1 Smad2 Foxh1 Acvr1b Smad3 Acvr2b Smad4 Inhbb Inha Tgfbr3 Mapk1 Mapk3 Fstl3 Acvr2a Inhba INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 96%264876 Insulin processing Exoc7 Slc30a5 Exoc8 Cltrn Slc30a8 Rab27a Pcsk1 Pcsk2 Cpe Myrip Ero1b Exoc3 Kif5c Exoc4 Exoc5 Kif5b Ins2 Exoc6 Vamp2 Exoc1 Stx1a Exoc2 Myo5a P4hb SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors Htr7 Htr1d Htr1f Htr2a Htr2c Htr1b Htr2b Htr1a Htr4 Htr5a Htr6 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 96%9734779 Developmental Cell Lineages of the Integumentary System Egf Tgfa Areg Prl Fgf10 ECM PROTEOGLYCANS%REACTOME%R-HSA-3000178.6 ECM proteoglycans Col9a2 Itgb5 Col9a3 Lum Tgfb1 Col9a1 Itgb3 Tgfb2 Lama5 Matn3 Vtn Ncan Bgn Lamb2 Lama1 Dcn Lama2 Bcan Vcan Lama3 Lama4 Fmod Lamc1 Lamb1 Itga8 Tgfb3 Musk Tnn Tnr Itgb6 Tnxb Matn1 Matn4 Lrp4 Aspn Dspp Ptprs Hapln1 Itgav Serpine1 Agrn Dag1 Tnc Itgax Comp Itga9 Ibsp Ncam1 Itga2b Hspg2 Itga7 Itga2 Sparc Itgb1 Dmp1 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters Slc6a5 Slc6a11 Slc6a13 Slc17a8 Slc25a18 Slc22a2 Slc6a3 Slc22a1 Slc25a22 Slc6a7 Slc6a9 Slc6a1 Slc6a4 Slc17a6 Slc6a19 Slc6a15 Slc6a14 Slc32a1 Slc6a20a Slc6a2 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 96%5579000 Defective CYP1B1 causes Glaucoma Cyp1b1 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 96%8941237 Invadopodia formation Sh3pxd2a Adam12 Adam15 Adam19 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654719 SHC-mediated cascade:FGFR4 Fgf16 Fgf15 Fgf18 Fgf2 Fgf1 Nras Fgf4 Fgf6 Sos1 Fgf9 Hras Fgf20 Fgf23 Fgfr4 Klb IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%381070 IRE1alpha activates chaperones Gfpt1 Arfgap1 Gsk3a Atp6v0d1 Acadvl Add1 Syvn1 Tln1 Mydgf Extl1 Srprb Dnajc3 Srpra Yif1a Edem1 Cul7 Dctn1 Ddx11 Cxxc1 Pdia6 Preb Pdia5 Ern1 Klhdc3 Serp1 Sec31a Kdelr3 Tspyl2 Fkbp14 Ssr1 Hyou1 Hdgf Extl2 Wipi1 Wfs1 Tatdn2 Gosr2 Extl3 Dnajb9 Zbtb17 Shc1 Hspa5 Tpp1 Dnajb11 Ppp2r5b Lmna TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI Pcna Rfc4 Rpa2 Rfc1 Rfc2 Rpa3 Ubc Mad2l2 Rev1 Rev3l Poli Rfc5 Rfc3 Rpa1 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73728 RNA Polymerase I Promoter Opening H2bu2 H2ac12 H2ac11 Mbd2 H2ac15 H3c7 H2bc14 H2bc9 H2ax H2bc7 H2ac20 H2bc8 H2bc3 H2bc21 Hist1h2bp H2bc26 Hist2h2aa1 Mapk3 H2aj H2ab2 Ubtf INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%9006925 Intracellular signaling by second messengers Rcor1 Jun Prkx Pip5k1b Pip5k1a Xiap Kdm1a Sgk1 Foxo3 Prkacb Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Stub1 Adcy9 Irak1 Esr2 Prkar1b Prkar2b Trp53 Rnf146 Tnks2 Tnks Trim27 Otud3 Wwp2 Usp13 Frk Casp9 Prkar2a Bad Mecom Camk2g Il1rl1 Camk2d Ahcyl1 Camk2b Camk2a Il33 Prkaca Itpr3 Camkk1 Itpr2 Camkk2 Itpr1 Sall4 Prkcg Ereg Hbegf Btc Epgn Mbd3 Ring1 Cbx8 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Nrg1 Phc3 Mdm2 Egfr Cdkn1a Ier3 Cdkn1b Phlpp1 Bmi1 Phlpp2 Flt3 Rps6kb2 Atn1 Maf1 Klb Fgf16 Ppp2cb Rnf2 Fgf15 Ppp2ca Irs1 Fgf18 Irs2 Fgf2 Fgf1 Bdnf Gab1 Fgf4 Plcg1 Fgf10 Fgf3 Ntf4 Fgf6 Fgf7 Ntrk2 Fgf9 Fgf20 Ntf3 Hdac2 Gab2 Hdac5 Fgf23 Egf Fgfr4 Fgf22 Myd88 Hdac7 Areg Pdgfb Egr1 Ppp2r1b Ppp2r1a Grk2 Pde1b Pten Pde1c Prkcd Nedd4 Pde1a Irak4 Ppp2r5d Ppp2r5c Ppp2r5b Cd19 Ppp2r5a Mkrn1 Insr Ppp2r5e Psma4 Foxo4 Psma3 Psma6 Foxo1 Psma5 Psma2 Tgfa Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Nr4a1 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Flt3l Mta1 Psma7 Mta3 Psmc6 Pip5k1c Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Traf6 Nrg2 Chuk Nrg4 Nrg3 Gsk3a Prkca Esr1 Pparg Trib3 Hdac1 Akt3 Akt2 Akt1 Prkar1a Strn Kit Camk4 Prkce Mov10 Chd3 Chd4 Ago4 Ago3 Nr2e1 Ago2 Ago1 Ezh2 Rest Snai2 Csnk2a2 Suz12 Cd28 Erbb2 Mta2 Rac1 Vav1 Pik3r5 Pik3r6 Pik3r1 Pik3r2 Pip4k2b Pip4k2a Rac2 Trat1 Pdgfrb Pik3ap1 Gatad2a Ntrk3 Gatad2b Rictor Cd86 Cd80 Src Pik3cg Pik3cb Pik3cd Hgf Met Pik3ca Mapk1 Mapk3 Prr5 Rptor Pdpk1 Csnk2b Frs2 Eed Them4 Usp7 Slc38a9 Lamtor5 Gsk3b Akt1s1 Lck Lamtor4 Rraga Mlst8 Rragb Lamtor1 Rragc Lamtor2 Rragd Tsc2 Mtor Ptpn11 Fyn Tnrc6c Rbbp4 Rbbp7 Atf2 Tnrc6a Tnrc6b Mapkap1 Rhog Hdac3 Pdgfra Snai1 Pml Ins2 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 96%8982491 Glycogen metabolism Pygl Ppp1r3c Pgm1 Pygm Ugp2 Phkg1 Phkb Phkg2 Nhlrc1 Epm2a Akr1e2 Phka1 Ubc Phka2 Gbe1 Gys1 Gys2 Gyg1 Gaa Pygb Agl REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674403 Regorafenib-resistant PDGFR mutants Pdgfra REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation Ppp2cb Usp2 Ppp2ca Trp53 Usp7 Mlst8 Rffl Mtor Atm Akt3 Cdkn2a Akt2 Akt1 Phf20 Rictor Chek2 Cdk1 Mapkap1 Sgk1 Ppp2r1b Ppp2r1a Prdm1 Mdm2 Ubc Cdk2 Mdm4 Ccna1 Ccna2 Daxx Rnf34 Prr5 Ppp2r5c Pdpk1 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME%R-HSA-9937080.2 Developmental Lineage of Multipotent Pancreatic Progenitor Cells Egf Fgf2 Fgf4 Fgf10 Fgf7 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 96%70263 Gluconeogenesis Pgk1 Pck2 G6pc1 Pcx Eno3 Aldob Eno2 Aldoc Pgk2 Aldoa Eno4 Fbp1 Fbp2 Gapdhs G6pc2 EG433182 Slc37a4 G6pc3 Gpi Pgam2 Slc37a1 Pgam1 Tpi1 Pck1 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades Dlg1 Rasgrp3 Dlg3 Rasgrp1 Jak3 Il3ra Dlg4 Il2rb Tyk2 Csf2rb2 Csf2ra Il5 Il5ra Jun Fnta Ppp1cb Fntb Foxo3 Prkacb Ncoa3 Spta1 Rbx1 Arl2 Sptb Ptk2 Sptan1 Ranbp9 Ptpn7 Ncam1 Dnajb1 Itga2b Sptbn1 Rag2 Rag1 Sptbn2 Il2rg Hspb1 Sptbn4 Cdc14a Gdnf Gfra1 Lypla1 Camk2g Camk2d Camk2b Camk2a Abhd17b Abhd17a Abhd17c Rce1 Rasal1 Rasal2 Rasal3 Prkaca Syngap1 Kbtbd7 Spred1 Spred3 Spred2 Rasa2 Rasa1 Rasa4 Rasa3 Nf1 Dab2ip Cul3 Ereg Hbegf Btc Epgn Rasgrf1 Rasgrf2 Il6 Nrg1 Ccnd3 Egfr Flt3 Il17rd Igf2bp1 Wdr83 Rgl3 Rgl1 Klb Rgl2 Fgf16 Ppp2cb Fgf15 Pea15 Ppp2ca Shoc2 Irs1 Mapkapk5 Fgf18 Mras Septin7 Irs2 Rapgef2 Fgf2 Mapk6 Fgf1 Mapk4 Fgf4 Cdc14b Fgf10 Rasgef1a Frs3 Fgf3 Cdc42ep2 Angpt1 Fgf6 Cdc42ep5 Etv4 Fgf7 Cdc42ep3 Tek Fgf9 Fgf20 Grin2b Icmt Fgf23 Egf Fgfr4 Fgf22 Bcl2l1 Areg Pdgfb Ppp2r1b Ppp2r1a Il6ra Dusp4 Dusp7 Dusp6 Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Ppp1cc Ppp2r5e Psma4 Psma3 Psma6 Foxo1 Fn1 Psma5 Psma2 Tgfa Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Flt3l Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Prkcq Nrg2 Rasgrp4 Dusp2 Nrg4 Dusp5 Nrg3 Paqr3 Zdhhc9 Dusp1 Il2 Dusp10 Dusp9 Dusp8 Golga7 Mark3 Prkg2 Myc Kit Mov10 Dlg2 Actn2 Nefl Ago4 Ago3 Grin1 Ago2 Grin2d Ago1 Ptpra Artn Erbb2 Gfra2 Kras Gfra3 Rac1 Gfra4 Jak1 Brap Pik3r1 Phb1 Pik3r2 Apbb1ip Arrb2 Iqgap1 Arrb1 Jak2 Fgb Pak1 Fga Rap1b Pspn Ksr1 Nrtn Vwf Pak3 Cnksr2 Pak2 Cnksr1 Fgg Araf Itgb3 Pebp1 Raf1 Tln1 Map3k11 Vcl Pdgfrb Ret Cdk1 Src Pik3cb Dusp16 Hgf Met Shc3 Pik3ca Shc2 Shc1 Mapk1 Braf Mapk3 Ywhab Mapk12 Rap1a Frs2 Ralgds Map2k2 Csf2 Nras Map2k1 Lamtor2 Sos1 Hras Ptpn11 Fyn Csk Tnrc6c Pde6d Tnrc6a Tnrc6b Ppp5c Il2ra Xpo1 Pdgfra Kalrn COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 96%9769740 Coagulation pathway Ano6 Fgb Ano5 Fga F2r Vwf Serpina10 Fgg Itgb3 Kng2 App Gp1ba Gpc1 Gpc3 Prtn3 Gpc2 Gpc5 Gpc4 Gpc6 Proc Serpind1 Serpinc1 Adamts13 F3 F5 F8 Pf4 Serpine1 Pros1 Agrn Proz F7 F9 Procr Serpina5 Serpine2 Smpd1 F13b Itga2b Cd177 Thbd F12 Hspg2 Klkb1 Sdc4 Sdc3 Sdc2 F10 F2 Serping1 Sdc1 Gp9 Gp1bb Gp5 F13a1 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619483 Activation of AMPK downstream of NMDARs Prkaa2 Camkk2 Prkag3 Prkab2 Prkab1 Prkag1 Prkag2 Prkaa1 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 Ppp2cb Yes1 Cd86 Ppp2ca Cd80 Lck Ppp2r5e Ptpn11 Fyn Akt3 Akt2 Akt1 Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Lyn Ppp2r1b Ctla4 Ppp2r1a SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 96%1483226 Synthesis of PI Cds1 Cdipt Pitpnm3 Pitpnm1 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 96%5693537 Resolution of D-Loop Structures Rbbp8 Rtel1 Brca2 Brca1 Xrcc3 Rad51ap1 Xrcc2 Atm Kat5 Exo1 Eme1 Mus81 Nbn Gen1 Fignl1 Brip1 Dna2 Rad51c Rad51d Blm Rad51b Bard1 Top3a Slx4 Wrn Mre11a Spidr Palb2 Sem1 Rad51 Rad50 Firrm 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency Hibch INTEGRATION OF PROVIRUS%REACTOME%R-HSA-162592.5 Integration of provirus Xrcc6 Psip1 Xrcc5 Hmga1 Xrcc4 Ppia Kpna1 Banf1 Lig4 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS Sftpb FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190373.6 FGFR1c ligand binding and activation Fgf23 Tgfbr3 Fgf2 Fgf1 Fgf4 Fgf6 Fgf9 Gipc1 Fgf20 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels Kcnj11 Abcc9 Gng10 Kcnj1 Kcnj3 Kcnj2 Gng3 Gng2 Gng4 Gng7 Gng8 Gabbr1 Gabbr2 Gngt1 Gngt2 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Kcnj14 Abcc8 Gnb2 Kcnj8 Gnb1 Kcnj10 Gnb4 Gnb3 Gnb5 Gng11 Kcnj12 Gng12 Gng13 Kcnj15 Kcnj16 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression Ptk6 Nr3c1 Hif1a Epas1 Pelp1 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition Rps5 Eif3m Eif3i Eif3l Eif3k Eif3f Eif3e Rps25 Eif3h Rps26 Eif3g Eif3b Eif3a Rps21 Eif3d Eif3c Eif4h Eif3j2 Eif4b Rps15a Eif4e Eif1ax Eif4a2 Eif2s3x Eif4a1 Eif2s2 Eif2s1 Rps27l Rps27 Rps3 Rps4x Rps14 Rps16 Eif5 Rps18 Rps19 Rpsa Rps10 Rps11 Eif4g1 Rps9 Rps7 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 96%5654741 Signaling by FGFR3 Fgf16 Ppp2cb Frs2 Ppp2ca Fgf18 Fgf2 Fgf1 Nras Fgf4 Gab1 Plcg1 Frs3 Sos1 Galnt3 Fgf9 Hras Fgf20 Ptpn11 Fgf23 Spry2 Ppp2r1a Mknk1 Cbl Ubc Pik3ca Mapk1 Braf Mapk3 Pik3r1 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA Acox3 Amacr Acot8 Hsd17b4 Crot Acoxl Crat Acox2 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9656255 Defective OGG1 Substrate Binding Ogg1 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism Slc26a2 Prelp Chst3 Chst5 Chsy1 Lum Chst14 Hexa Hexb Gpc1 Ncan Bgn Gpc3 Cspg5 Gpc2 Omd Cspg4 Dcn Ogn Hspg2 Bcan Gpc5 Sdc4 Vcan Sdc3 Gpc4 Sdc2 Fmod Gpc6 B4galt7 B4galt1 Papss2 Ext2 Ext1 Sdc1 Kera Agrn B3gat3 B3galt6 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade Dlg1 Rasgrp3 Dlg3 Rasgrp1 Jak3 Il3ra Dlg4 Il2rb Csf2rb2 Csf2ra Il5 Il5ra Fnta Ppp1cb Fntb Spta1 Rbx1 Arl2 Sptb Ptk2 Sptan1 Ranbp9 Ptpn7 Ncam1 Itga2b Sptbn1 Sptbn2 Il2rg Sptbn4 Gdnf Gfra1 Lypla1 Camk2g Camk2d Camk2b Camk2a Abhd17b Abhd17a Abhd17c Rce1 Rasal1 Rasal2 Rasal3 Syngap1 Kbtbd7 Spred1 Spred3 Spred2 Rasa2 Rasa1 Rasa4 Rasa3 Nf1 Dab2ip Cul3 Ereg Hbegf Btc Epgn Rasgrf1 Rasgrf2 Nrg1 Egfr Flt3 Il17rd Wdr83 Rgl3 Rgl1 Klb Rgl2 Fgf16 Ppp2cb Fgf15 Pea15 Ppp2ca Shoc2 Irs1 Fgf18 Mras Irs2 Rapgef2 Fgf2 Fgf1 Fgf4 Fgf10 Rasgef1a Frs3 Fgf3 Angpt1 Fgf6 Fgf7 Tek Fgf9 Fgf20 Grin2b Icmt Fgf23 Egf Fgfr4 Fgf22 Bcl2l1 Areg Pdgfb Ppp2r1b Ppp2r1a Dusp4 Dusp7 Dusp6 Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Ppp1cc Ppp2r5e Psma4 Psma3 Psma6 Fn1 Psma5 Psma2 Tgfa Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Flt3l Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Prkcq Nrg2 Rasgrp4 Dusp2 Nrg4 Dusp5 Nrg3 Paqr3 Zdhhc9 Dusp1 Il2 Dusp10 Dusp9 Dusp8 Golga7 Mark3 Prkg2 Kit Dlg2 Actn2 Nefl Grin1 Grin2d Ptpra Artn Erbb2 Gfra2 Kras Gfra3 Gfra4 Jak1 Brap Pik3r1 Phb1 Pik3r2 Apbb1ip Arrb2 Iqgap1 Arrb1 Jak2 Fgb Fga Rap1b Pspn Ksr1 Nrtn Vwf Cnksr2 Cnksr1 Fgg Araf Itgb3 Pebp1 Raf1 Tln1 Map3k11 Vcl Pdgfrb Ret Src Pik3cb Dusp16 Hgf Met Shc3 Pik3ca Shc2 Shc1 Mapk1 Braf Mapk3 Ywhab Mapk12 Rap1a Frs2 Ralgds Map2k2 Csf2 Nras Map2k1 Lamtor2 Sos1 Hras Fyn Csk Pde6d Ppp5c Il2ra Pdgfra RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%8868766 rRNA processing in the mitochondrion Hsd17b10 Prorp Trub2 Nsun4 Trmt10c Rpusd4 Tfb1m Mterf4 Mterf3 Rcc1l Mrm1 Mrm2 Mrm3 Ngrn Elac2 Fastkd2 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%5357801 Programmed Cell Death Tlr4 Apaf1 Bmx Ppp3r1 Psma4 Psma3 Il18 Psma6 Birc3 Psma5 Birc2 Psma2 Peli1 Chmp2a Psma1 Tradd Ticam2 Traf2 Ticam1 Trp63 Bcl2l11 Psmd12 Sdcbp Cd14 Psmd11 Ywhae Prkn Psmd14 Xiap Fasl Fnta Psmd13 Chmp3 Tnfsf10 Chmp7 Psmb5 Chmp6 Psmb4 Irf2 Lmnb1 Tnfrsf10b Psmb7 Psmb6 Fadd Ube2l3 Psmb1 Psmb3 Gzmb Flot2 Psmb2 Flot1 Elane Itch Ripk3 Dsp Chmp4c Psma7 Chmp4b Tjp1 Psmc6 Bak1 Casp3 Pkp1 Psmc5 Casp8 Dsg2 Psmc2 Casp4 Dsg3 Psmc1 Casp1 Dsg1a Ripk1 Psmc4 Psmc3 Stub1 Tjp2 Ubc Gsdme Pdcd6ip Gsdmd Psmd7 Psmd6 Il1a Il1b Ptk2 Bax Psmd8 Fas Ogt Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Prkcq Aven Sptan1 Uaca Trp73 Diablo Satb1 Trp53 Gsn Casp7 Gas2 Ywhah Dbnl Add1 Plec Akt3 Dcc Akt2 Akt1 Kpna1 Hmgb2 Dffa Dffb Ywhaz Casp9 Bad Nmt1 Casp6 Sfn Kpnb1 Hsp90aa1 Maged1 Dapk1 Unc5b Dapk2 Unc5a Dapk3 Appl1 Mlkl Apip Pak2 Mapk8 H1f2 H1f3 Cdkn2a Stat3 Bid Cdc37 Ctnnb1 Tfdp2 H1-1 Tfdp1 Rock1 H1-0 Vim Cdh1 H1-5 H1-4 Ppp1r13b E2f1 Mapk1 Mapk3 Ywhab Ywhag Bcap31 Irf1 Trp53bp2 Bcl2 Bcl2l1 Dynll1 Dynll2 Clspn Stk26 Stk24 Oma1 Dnm1l Opa1 Apc Acin1 C1qbp Prkcd Arhgap10 Bmf Ppp3cc Ly96 PKR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9833482 PKR-mediated signaling Adar Cenps Dhx9 Ikbkb Isg15 Dnajc3 Eif2s3x Ikbkg Stat3 Eif2s2 Eif2s1 Stat1 Fancc Arih1 Cdk1 Hspa1a Trim25 Sphk1 Mavs Npm1 Hspa8 Cenpx Chuk Map2k6 Ppp2cb Ppp2ca Trp53 Ptpn2 Ube2i Nck1 Snca Ppp2r1b Fancl Ppp2r1a Fancm Fanca Fancb Fance Fancf Fancg Hspa1l Dus2 Ube2l6 Faap24 Eif2ak2 Prkra Faap20 Tarbp2 Ilf2 Ilf3 Ppp2r5a Faap100 Hspa2 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 96%210993 Tie2 Signaling Grb14 Angpt2 Angpt4 Grb7 Nras Angpt1 Pik3cb Sos1 Tek Hras Ptpn11 Pik3ca Shc1 Pik3r1 Pik3r2 Dok2 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%352238 Breakdown of the nuclear lamina Casp6 Lmnb1 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 96%189085 Digestion of dietary carbohydrate Amy2a5 Amy1 Sis Chit1 Mgam Lct Treh Chia C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) Nfatc1 Nfatc3 Nfatc2 Ppp3r1 Ppp3ca Ppp3cb Psma4 Ikbkb Muc15 Psma3 Muc13 Plcg2 Psma6 Psma5 Psma2 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Malt1 Psmb5 Prkacb Ube2m Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Card11 Btrc Psma7 Psmc6 Muc1 Psmc5 Casp8 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Muc4 Bcl10 Muc6 Psmd7 Muc20 Psmd6 Il1b Syk Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Cul1 Traf6 Ube2n Chuk Pycard Cdc34 Ube2v1 Tab3 Tab2 Tab1 Uba3 Lyn Ahcyl1 Nfkb2 Prkaca Pak1 Itpr3 Itpr2 Itpr1 Pak3 Pak2 Raf1 Map3k14 Ube2d1 Pdpk1 Fcer1g Nras Hras Fyn Cd209a Relb Rps6ka5 Icam2 Ep300 Clec7a Clec10a Clec4n Prkcd Clec4a2 Clec4d Clec4e Clec4b2 Card9 Crebbp GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Eif2s3x Eif2s2 Eif2s1 Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Eif4g1 Eif3m Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Eif4h Eif3j2 Eif4b Eif4e Eif1ax Eif4a2 Eif4a1 Rps27 Rps14 Rpl4 Eif5b Rps16 Eif5 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi Notch2 Notch3 St3gal6 Atp2a3 Sel1l Atp2a2 B4galt1 Notch1 Rab6a Mfng Rfng St3gal4 Furin Lfng Notch4 Atp2a1 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Hadha Echs1 Hadhb Hadh Mecr Acadm GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors F2 Ggcx Pros1 Gas6 Proz F7 F9 F10 Proc DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665230 Drug resistance in ERBB2 KD mutants Erbb2 Cdc37 Erbin Hsp90aa1 THE NLRP3 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844456 The NLRP3 inflammasome Pycard Nlrp3 Pstpip1 Rela Sugt1 P2rx7 Casp1 App Panx1 Nfkb2 Mefv Txnip Nfkb1 Txn Hmox1 Hsp90ab1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Nrp1 Pip5k1c Rnd1 Rras Tln1 Sema3a Fyn Rac1 Plxna1 Plxna4 Plxna3 Plxna2 Fes Farp2 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) Slc6a19 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME%R-HSA-9763198.2 Impaired BRCA2 binding to SEM1 (DSS1) Brca2 Sem1 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 96%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors Cnot9 Cnot6l Cnot8 Cnot11 Pabpc1 Paip1 Eif4b Eif4e Eif4a2 Eif4a1 Cnot10 Tnks1bp1 Ago2 Eif4a3 Btg4 Zfp36l2 Pabpn1l Dicer1 Cnot3 Cnot2 Cnot1 Cnot7 Cnot6 Eif4g1 Cnot4 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB Camk2b Camk2a Camkk1 Camkk2 Camk2g Camk4 Camk2d REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 96%9010553 Regulation of expression of SLITs and ROBOs Col4a5 Psma4 Robo1 Psma3 Psma6 Psma5 Psma2 Psma1 Slit2 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Msi1 Psmd1 Dag1 Adrm1 Isl1 Sem1 Upf3a Gspt2 Gspt1 Lhx2 Lhx3 Cul2 Lhx9 Lhx4 Pabpc1 Slit1 Ldb1 Upf2 Usp33 Zswim8 Etf1 Robo2 Hoxa2 Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Eif4g1 Rnps1 Magoh Rps27 Rbm8a Upf3b Eif4a3 Casc3 Magohb Ncbp2 Ncbp1 Eloc INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 96%9014843 Interleukin-33 signaling Il33 Il1rl1 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 96%380095 Tachykinin receptors bind tachykinins Tacr1 Tacr3 Tacr2 Tac3 Tac1 ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964540 Alanine metabolism Gpt RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8931987 RUNX1 regulates estrogen receptor mediated transcription Esr1 Cbfb Kctd6 Gpam Axin1 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 96%400508 Incretin synthesis, secretion, and inactivation Gnat3 Gata4 Grp Cdx2 Ffar4 Ctnnb1 Pcsk1 Ffar1 Pax6 Gpr119 Gcg Spcs3 Spcs1 Lep Spcs2 Gnb1 Gnb3 Isl1 Gip Gng13 Tcf7l2 Sec11c Sec11a Dpp4 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Rps27l Rplp2 Rps27 Eef2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9679514 SARS-CoV-1 Genome Replication and Transcription Vhl Rb1 Zcrb1 Ddx5 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 96%77042 Formation of editosomes by ADAR proteins Adar Adarb1 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 96%173599 Formation of the active cofactor, UDP-glucuronate Ugp2 Ugdh Slc35d1 Uxs1 Slc35d2 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 96%9022702 MECP2 regulates transcription of neuronal ligands Dll1 Sin3a Sst Bdnf Hdac1 Crh CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants Hey2 Hey1 Mib2 Ncor2 Skp1 Mamld1 Notch1 Rbx1 Ubc Kat2b Kat2a Cul1 Hdac2 Hdac1 Hdac5 Hdac4 Myc Hdac7 Hdac6 Hdac9 Hdac8 Ncor1 Dll4 Hes1 Jag2 Jag1 Adam10 Ep300 Cdk8 Neurl1b Tbl1x Adam17 Neurl1a Dll1 Mib1 Hdac3 Tbl1xr1 Psen1 Psen2 Ncstn Maml1 Aph1b Maml2 Heyl Hdac11 Hdac10 Hes5 Rbpj Ccnc Crebbp SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants Ppp1cc Shoc2 Mras Braf Ywhab Ppp1cb Araf Raf1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) Arrb1 F2r Gng10 Gng3 Gna12 Gng2 Gng4 Gna13 Gng7 Gng8 F2 Gngt1 Gngt2 Gna11 Gna15 Gna14 Mapk1 F2rl2 Gnb2 F2rl3 Mapk3 Gnaq Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 Arrb2 SARS-COV-2 INFECTION%REACTOME%R-HSA-9694516.9 SARS-CoV-2 Infection Gja1 Larp1 Tyk2 Chmp2a Ifnar1 Ywhae Chmp3 Stat2 Ddx5 Chmp7 Chmp6 Nlrp3 Chmp4c Chmp4b Irak1 Nrp1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Hspg2 Nup62 Nup88 Sdc4 Sdc3 Aaas Sdc2 Nup214 Nup210 Nup155 Nup153 Sdc1 Rps14 Rps16 Rps18 Rps19 Rpsa Sfn Rps10 Rps11 Hsp90aa1 Rps9 Rps7 Rps5 Rps25 Rps26 Rps21 Havcr1 Ace2 Isg15 Tmprss2 Rps15a Gpc1 Gpc3 Gpc2 Rps27l Gpc5 Gpc4 Gpc6 Canx Rps3 Rps4x Rb1 Agrn Ifnb1 Nup37 Nup160 Nup43 Pik3c3 Ranbp2 Ripk2 Nup107 Pik3r4 Rps27 Gemin7 Gemin4 Nod2 Gemin5 Nod1 Snrpb Smn1 Snrpd2 Tkfc Snrpd1 Nup85 Irak2 Snrpd3 Gemin2 Ddx20 Tlr8 Tlr7 Sec13 Ano10 Ano8 Ano7 Ano6 Mbl2 Ano5 Ano4 Ano2 Ano1 Sting1 Prmt1 Irf7 Ikbkb Nup133 Ikbkg Traf3 Map3k7 Ikbke B2m H2-Q10 Tjp1 Ubc Map1lc3b Becn1 Uvrag Iscu Parp14 Traf6 Parp16 Ube2n Galnt1 Chuk Parp4 Parp6 Ganab Mgat5 Gsk3a Parp8 Zdhhc9 Ube2v1 Parp10 Man2a1 Tab3 Parp9 Zdhhc11 Tab2 Mgat2 Tab1 Mgat1 Mogs Golga7 Edem2 Fut8 St6galnac3 St6galnac4 Ywhah St6galnac2 St3gal4 Mgat4c Ube2i Mgat4a St3gal2 Akt3 Mgat4b Akt2 St3gal1 Akt1 Man1b1 Zdhhc20 Prkcsh St6gal1 Zdhhc8 Zdhhc5 Rpn2 Zdhhc3 Rpn1 Zdhhc2 Ywhaz Il17rc Il17ra Vps39 Vps18 Vps11 Vps16 Cav1 Jak1 Zcrb1 Vps41 Vps45 Vhl Magt1 Tufm Tmem258 Stat1 Tlr1 Tlr2 Sftpd Ifih1 Hsp90ab1 Sike1 Rnf135 Trim25 Stt3a Mavs Stt3b Rigi Srpk1 Srpk2 Vcp Vps33a Vps33b Ostc Crb3 Patj Pals1 Tusc3 Tomm70 Furin Ywhab Dad1 Ywhag Pdpk1 Ddost Gsk3b Csnk1a1 Nlrp12 Ptpn6 Ptpn11 H2-M5 H2-M3 Tbk1 G3bp1 G3bp2 Irf3 H2-Q1 Cnbp Sar1b Sec23a Il17f Il17a Sec24d Sec24c Crebbp Sec24b Sec24a REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9762293 Regulation of CDH11 gene transcription Sp1 Hoxc8 Heyl Snai1 Prdm8 Zeb2 Ilf3 Foxf1 Bhlhe22 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling Nrg3 Cdc37 Erbin Nrg1 Ptpn18 Rnf41 Ptpn12 Usp8 Stub1 Egfr Matk Ubc Erbb2 Egf Akt3 Ereg Akt2 Hbegf Akt1 Btc Cul5 Hsp90aa1 Nrg2 Nrg4 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 96%3229121 Glycogen storage diseases Ppp1r3c Gbe1 Slc37a4 G6pc3 G6pc1 Epm2a Gys1 Nhlrc1 Gys2 Gyg1 Gaa Ubc MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 96%166187 Mitochondrial Uncoupling Slc25a27 Ucp2 Slc25a4 Ucp3 Ucp1 Slc25a14 Pm20d1 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling Nfatc1 Ppp3r1 Ppp3ca Ppp3cb Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Map3k7 Ap2m1 Psmd12 Psmd11 Psmd14 Psmd13 Smurf2 Dvl1 Smurf1 Dvl2 Dvl3 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Ap2a2 Psmb3 Psmb2 Ap2a1 Prkcb Vangl2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Ap2b1 Wnt5a Psmd7 Ap2s1 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Pfn1 Wnt11 Ryk Plcb3 Plcb2 Plcb1 Pde6g Gng10 Prkca Gnao1 Nlk Gnat2 Prkg2 Pde6a Pde6b Prkg1 Prickle1 Gng3 Gng2 Gng4 Gng7 Tcf7l1 Gng8 Tcf7l2 Mov10 Wnt1 Wnt4 Ago4 Fzd1 Ago3 Gngt1 Ago2 Gngt2 Ago1 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Scrib Fzd8 Daam1 Rac1 Camk2a Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 Arrb2 Itpr3 Itpr2 Itpr1 Prkcg Rac2 Clta Cltc Cltb Ctnnb1 Tcf7 Rac3 Lef1 Pard6a Rhoa Tnrc6c Tnrc6a Tnrc6b Wnt5b Ror1 Ror2 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610785 GLI3 is processed to GLI3R by the proteasome Prkaca Gsk3b Csnk1a1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Gli3 Psmb5 Prkacb Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Sufu Psmd1 Adrm1 Sem1 Cul1 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5619113.4 Defective SLC3A1 causes cystinuria (CSNU) Slc3a1 Slc7a9 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654700 FRS-mediated FGFR2 signaling Fgf16 Frs2 Fgf18 Fgf2 Fgf1 Nras Fgf4 Fgf10 Frs3 Fgf3 Fgf6 Sos1 Fgf7 Fgf9 Hras Fgf20 Ptpn11 Fgf23 Fgf22 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 96%8955332 Carboxyterminal post-translational modifications of tubulin Ttll10 Tubb6 Nicn1 Tubb3 Agbl5 Agbl1 Tubb1 Agbl2 Agbl3 Ttll11 Ttll12 Agtpbp1 Lrrc49 Tubb4b Tuba1b Svbp Tubb4a Tuba1a Vash1 Vash2 Tpgs1 Tuba1c Tpgs2 Tubb2b Tubb2a Ttll6 Ttll7 Tuba3b Ttll4 Ttll5 Ttll3 Ttll1 Ttl Ttll9 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660516 Synthesis of PIPs at the early endosome membrane Mtmr2 Mtm1 Pik3c3 Pikfyve Fig4 Vac14 Pi4k2a Mtmr4 Inpp4a Pik3c2a Inpp4b Pik3r4 Mtmr10 Mtmr12 Inpp5f Pi4k2b DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME%R-HSA-5083627.3 Defective LARGE causes MDDGA6 and MDDGB6 Large1 B4gat1 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 96%9913351 Formation of the dystrophin-glycoprotein complex (DGC) Sntg2 Dtna Dtnb Lama5 Sgcz Snta1 Lamb2 Sspn Lama1 Dmd Lamc3 Lamb3 Sntb2 Hspg2 Sntb1 Lama2 Sgce Lama3 Sgcd Lama4 Sgcb Lamc1 Lamb1 Sgca Lamc2 Sgcg Utrn Drp2 Agrn Dag1 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) Snap25 Sv2b Sv2a CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 96%69278 Cell Cycle, Mitotic Golga2 Chmp2a Ywhae Chmp3 Cdc25c Chmp7 Chmp6 Lmnb1 Cdc25b Cdc25a Chmp4c Rbx1 Chmp4b Top2a Prkar2b Lig1 Nek9 Nek6 Nek7 Prkaca Ppp1r12a Cdkn2a Cdkn2b Cdkn2c H3c8 Ccne1 Ccne2 Fzr1 Tfdp2 Tfdp1 Skp2 Rb1 Ccnd2 Ccnd3 Ccnd1 Cdk6 Cdk4 Cdk2 E2f1 E2f2 Ccna1 E2f3 Ccna2 Cdkn1a Cdkn1b Cdkn1c Clasp1 Clasp2 Pafah1b1 Smc3 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Rad21 Kif2b Kif2c Dync1li2 Pmf1 Wapl Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Stag2 Stag1 Ppp2r1b Ppp2r1a Pds5b Pds5a Ndc80 Kif18a Nudc Hmmr Dync1h1 Birc5 Spc24 Spc25 Ercc6l Nuf2 Ccnb2 Nup85 Cdca8 Incenp Cdca5 Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Akap9 Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Nedd1 Cenps Cenpq Actr1a Cenpp Ppp2r5e Cenpo Cenpn Cenpm Spast Dctn2 Espl1 Mis12 Dctn3 Lemd2 Nup133 Cenpl Cc2d1b Ist1 Zwilch Cenpk Vrk1 Cenpi Sirt2 Cenph Smc1a Cenpf Cenpe Optn Pcnt Cep250 Sdccag8 Cep78 Cep76 Cep72 Cep70 Tubb5 Plk4 Mnat1 Cep135 Cep131 Ccnh Cdk7 Prkca Haus7 Haus8 H2ac20 Cdk5rap2 Myc Akt3 Akt2 Akt1 Eml4 Cep57 Tyms Dhfr Pcm1 Tk1 Dyrk1a Ssna1 Tubg1 Lyn Ofd1 Pttg1 H2ac12 H2ac11 Kif23 Kif20a H2ac15 Cep63 H3c7 Cep152 Haus3 H2ax Csnk2a2 Haus4 Haus5 Rcc1 Haus6 Sfi1 Csnk1d Haus1 Vps4a Hist1h2bp Haus2 H2aj Cep164 Ccp110 Alms1 Smc4 Smc2 Cetn2 Tubgcp2 Tnpo1 Numa1 Ncaph Rab8a Tubg2 Ncapd2 Nme7 H2bc9 Tubgcp5 H2bc7 Tubgcp4 H2bc8 Cdc7 Cep43 Tubgcp3 Mzt1 H2bc3 Mzt2 Cep41 Ninl H2ab2 Nek2 Pkmyt1 H2bu2 Hist2h2aa1 Ywhag Csnk2b Gsk3b Csnk1e H2bc14 H2bc21 H2bc26 Rbbp4 Abl1 Lcmt1 Obi1 Bora Ppme1 Ticrr Cdk11b Ajuba Emd Lemd3 Lbr Tuba1b Tuba1a Fbxo5 Tpx2 Tuba1c Ankle2 Tubal3 Tubb2b Ppp1cb Tubb2a Lpin3 Lpin2 Lpin1 Tuba4a Tuba8 Ppp2r2a Tuba3b Tubb6 Tubb3 Trp53 Tubb1 Tubb4b Tubb4a Nup93 Nup50 Nup35 Mybl2 Nup54 Pom121 Nup205 Nup188 Rbl2 Tpr Rae1 Ndc1 Nup42 Nup62 Rbl1 Nup88 Aurka Aaas Nup214 Banf1 Nup210 Nup155 Cdc14a Nup153 Orc5 Orc4 Orc6 Orc1 Mcm8 Orc3 Orc2 Kpnb1 Hsp90aa1 Ran Kmt5a Max Cdt1 Cpap Gmnn Fen1 Dbf4 Mcm10 E2f4 E2f5 E2f6 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Nipbl Psmb4 Psmb7 Ensa Psmb6 Rab2a Psmb1 Ctdnep1 Psmb3 Cnep1r1 Psmb2 Blzf1 Fbxw11 Ppp2r2d Ncaph2 Arpp19 Prkcb Ncapd3 Btrc Ncapg2 Psma7 Mau2 Psmc6 Gorasp2 Psmc5 Rab1a Mastl Psmc2 Mcph1 Psmc1 Rab1b Psmc4 Psmc3 Ubc Psmd7 Uso1 Psmd6 Fkbpl Gtse1 Phlda1 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Gorasp1 Sem1 Cul1 Mis18bp1 Hdac1 Fbxl7 Ube2i Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Rfc1 Rfc2 Pold4 Pold3 Dna2 Pole3 Pole2 Pole4 Rrm2 Firrm Rpa1 Jak2 Rpa2 Rpa3 Fbxl18 Pole Plk1 Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdk1 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Hsp90ab1 Cdc23 Anapc15 Gins2 Gins1 Mcm7 Gins4 Gins3 Mcm3 Mcm4 Ptk6 Mcm5 Cks1b Cables1 Mcm6 Lin54 Cdc45 Mapk1 Esco1 Mcm2 Esco2 Lin9 Wee1 Lin37 Foxm1 Cdc6 Ep300 Prim2 Prim1 Pola2 Pola1 Xpo1 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope Pkp2 Jup Klk12 Pkp3 Dsg4 Lipk Dsc1 Klk14 Rptn Dsc2 Lipn Dsc3 Capn1 Capns1 Klk13 Dsp Pkp1 Dsg2 St14 Dsg3 Cdsn Dsg1a Loricrin Klk5 Kazn Sprr1b Klk8 Ppl Tgm1 Lce1m Furin Tgm5 Casp14 Pcsk6 Lce3b Tchh Pkp4 Prss8 Evpl Cela2a Spink5 Perp Csta2 Sprr2k REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764265 Regulation of CDH1 Expression and Function Sp1 Arhgap32 Psma4 Psma3 Psma6 Banp Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Kdm1a Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Zfp217 Psma7 Psmc6 Pip5k1c Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Ank3 Psmd3 Psmd2 Pomt1 Psmd1 Adrm1 Sem1 Pomt2 Ganab Mogs Tgif2 H2ac20 Tcf3 Zeb1 Klf9 Hdac1 Strap Foxj2 Foxp2 Myc Prkcsh Rpn2 Rpn1 Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 Twist2 Ezh2 H2ax Twist1 Snai2 Csnk2a2 Suz12 Hist1h2bp H2aj Jup H2bc9 H2bc7 H2bc8 H2bc3 Vcl Tmem258 H2ab2 Mycn Sec11c Sec11a H2bu2 Stt3a Src Canx Ctnnb1 Eps15 Cbll1 Ostc Rb1 Arid1a Tcf12 Ctnnd1 Cdh1 Dnm2 Kmt5a Mdm2 Zmym2 Mapk1 Mapk3 Hist2h2aa1 Furin Ctbp1 Mtbp Pcsk6 Ctbp2 Dad1 Rack1 Foxq1 Wt1 Ddost Csnk2b Eed Tle1 Pcsk7 Pkm H2bc14 Foxa2 Zbtb33 Hdac2 Mphosph8 Tfap2a Mcrip1 H2bc21 Tnrc6c H2bc26 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Smarca4 Zeb2 Ctsb Ctss Spcs3 Spcs1 Spcs2 Ctnna1 Snai1 Klf4 Sirt1 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation Pbx1 H2bc9 H2bc7 H2bc8 Jun H2bc3 Pcgf2 H2ab2 Kdm6a Yy1 Rarb H2bu2 Ncoa3 Polr2c Polr2d Polr2a Rarg Polr2b Polr2g Kmt2c Polr2h Hist2h2aa1 Polr2e Polr2f Polr2k Polr2i Polr2j Dpy30 Cnot6 Wdr5 Eed Cnot9 Kmt2d Pax6 H2bc14 H2ac20 Egr2 Rxra Rara H2bc21 H2bc26 Pagr1a Rbbp5 Hoxc4 Rbbp4 Ctcf Ncor1 Rbbp7 Hoxd1 Pias2 Hoxb3 Hoxa2 Hoxb1 Hoxb2 Paxip1 Ep300 Hoxa3 Hoxa1 Ajuba Hoxa4 Pknox1 H2ac12 Mafb H2ac11 Zfp335 Meis1 Hdac3 Hoxd3 Hoxd4 H2ac15 H3c7 Ezh2 H2ax Hoxb4 Suz12 Ncoa6 Ash2l Hist1h2bp H2aj Crebbp PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9609507 Protein localization Sec61b Stx5 Otof App Gnpat Pmpcb Ube2d3 Ubc Slc25a12 Slc25a13 Pmpca Lonp2 Vdac1 Samm50 Chchd3 Dhrs4 Idh1 Phyh Amacr Mpv17 Ide Hacl1 Mtx1 Gstk1 Mtx2 Pex26 Crot Scp2 Paox Timm50 Crat Hspa9 Timm17b Acox1 Pex11b Acox2 Cmc2 Atp5f1b Nudt19 Grpel2 Ech1 Atp5f1a Timm9 Acot2 Acox3 Chchd7 Chchd4 Pex1 Chchd5 Pex7 Bag6 Pex6 Pipox Pxmp4 Tysnd1 Pxmp2 Tomm22 Hspd1 Baat COA4 Ddo Fis1 Zfand6 Timm44 Agps Hao1 Cox19 Cox17 Agxt Hao2 Aco2 Pitrm1 Nudt7 Pecr Timm10 Slc25a5 Timm13 Nos2 Dao Timm8b Serp1 Slc25a4 Ephx2 Cs Cat Tomm40 Ubl4a Get1 Get3 Get4 Coa6 Timm22 Timm21 Ldhd Camlg Chchd10 Sgta Tomm6 Gfer Tomm7 Slc25a17 Tafazzin Gdap1 Idh3g Vapa Timm10b Ndufb8 Atad1 Timm8a1 Dnajc19 Pex16 Prnp Grpel1 Usp9x Cyc1 Pex2 Hscb Ube2d1 Pex14 Pex13 Pex12 Pex10 Acot8 Hsd17b4 Ehhadh Fxn Acaa1a Bcs1l Slc27a2 Hmgcl Abcd1 Decr2 Acot4 Pex3 Tomm70 Abcd2 Abcd3 Acbd5 Otc Vamp2 Stx1a Hmox1 Coq2 Emd Pex19 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane Prkaca Ccp110 Alms1 Cetn2 Nedd1 Rab8a Cc2d2a Tmem67 Actr1a Tuba1a Cep97 Cep43 Dctn2 Cep41 Dctn3 Plk1 Sclt1 Ninl Rpgrip1l Rab11a Ywhae Cdk1 Nek2 Pcnt Tuba4a Fbf1 Cep250 Sdccag8 Cep78 Cep76 Iqcb1 Cep72 Cep70 Tubb5 Plk4 Cpap Clasp1 Ywhag Pafah1b1 Ahi1 Cep89 Cep135 Nphp4 Cep131 Cep83 Prkar2b Mks1 Nphp1 Csnk1e Tubb4b Haus7 Tubb4a Haus8 Cdk5rap2 C2cd3 Mark4 Cep57 Pcm1 Mapre1 Dynll1 Ssna1 Tubg1 Ppp2r1a Ofd1 Septin2 Dync1h1 Cep162 Cep63 Rab3ip Cep152 Haus3 Kif24 Haus4 Haus5 Haus6 Sfi1 Dync1i2 Ttbk2 Csnk1d Haus1 Ckap5 Haus2 Tctn3 Tctn1 Akap9 Tctn2 Hsp90aa1 B9d2 Cep164 B9d1 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME%R-HSA-5655799.4 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Slc40a1 Heph DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 Cyp2u1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity Smad2 Tgif1 Smad3 Tgif2 Smad4 Rnf111 Usp9x Hdac1 Smad7 Ncor2 Parp1 Ncor1 Smurf2 Ube2d1 Trim33 Ski Ube2d3 Skil Ubc Wwtr1 Mapk1 Nedd4l Mapk3 Atp1b4 Ppm1a MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition Plk1 Fbxo5 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 96%381038 XBP1(S) activates chaperone genes Gfpt1 Arfgap1 Gsk3a Atp6v0d1 Acadvl Add1 Syvn1 Tln1 Mydgf Extl1 Srprb Dnajc3 Srpra Yif1a Edem1 Cul7 Dctn1 Ddx11 Cxxc1 Pdia6 Preb Pdia5 Klhdc3 Serp1 Sec31a Kdelr3 Tspyl2 Fkbp14 Ssr1 Hyou1 Hdgf Extl2 Wipi1 Wfs1 Tatdn2 Gosr2 Extl3 Dnajb9 Zbtb17 Shc1 Tpp1 Dnajb11 Ppp2r5b Lmna MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME%R-HSA-5657655.3 MGMT-mediated DNA damage reversal Mgmt LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%166662 Lectin pathway of complement activation Colec11 Mbl2 Fcn2 Colec10 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F2 Pros1 Gas6 Proz F7 F9 F10 Proc MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation Jak2 Mapk1 Map2k2 Jak1 Il6ra Tyk2 Il6 Ptpn11 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling Ngf Ngfr Smpd2 DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 96%3359467 Defective MTRR causes HMAE Mtrr Mtr SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 96%425561 Sodium Calcium exchangers Slc24a1 Slc8a1 Slc24a5 Slc8a2 Slc8a3 Slc24a4 Sri Slc24a3 Slc8b1 Slc24a2 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism Bcat1 Bcat2 Acad8 Bckdhb Bckdk Hibadh Bckdha Slc25a44 Hsd17b10 Dbt Glyat Acadsb Dld Crat Acat1 Echs1 Hibch Mccc1 Auh Ivd Mccc2 Ppm1k Aldh6a1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-HSA-418592.5 ADP signalling through P2Y purinoceptor 1 Pla2g4a Gngt1 Gngt2 P2ry1 Gna11 Gng10 Gna15 Gna14 Gng3 Gng2 Gnb2 Gnaq Gnb1 Gng4 Gnb4 Gnb3 Gng7 Gnb5 Gng11 Gng8 Gng12 Mapk14 Gng13 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022854 Keratan sulfate biosynthesis Prelp Chst3 Chst2 Chst5 St3gal6 Lum St3gal4 St3gal2 St3gal1 Omd Ogn Slc35d2 Fmod B4galt4 B4galt5 B4galt6 B4gat1 B4galt1 B4galt2 B4galt3 B3gnt3 B3gnt7 Kera B3gnt4 B3gnt2 Chst1 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 96%380612 Metabolism of serotonin Maoa Aldh2 SELECTIVE AUTOPHAGY%REACTOME%R-HSA-9663891.5 Selective autophagy Usp30 Pex5 Map1lc3a Fundc1 Atg5 Atg12 Atg9a Nbr1 Atm Plin3 Ift88 Prkn Sqstm1 Optn Ube2l3 Pcnt Vcp Mfn1 Mfn2 Prkag3 Ulk1 Prkag1 Vdac2 Ube2d3 Prkag2 Hspa8 Ubc Vdac3 Tomm70 Map1lc3b Vdac1 Epas1 Ube2n Csnk2b Ube2v1 Hsf1 Dync1li2 Prkaa2 Dync1li1 Tbk1 Hdac6 Arl13b Tomm22 Dynll1 Dynll2 Prkab2 Prkab1 Cftr Tomm40 Cetn1 Plin2 Dync1h1 Park7 Csnk2a2 Mterf3 Pink1 Tomm6 Dync1i2 Tomm7 Dync1i1 Hsp90aa1 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 96%597592 Post-translational protein modification Gpld1 Thy1 Kdelr2 Etfbkmt Pigc Pigb Suds3 Piga Pigk Pigm Pigl Pigg Pigf Pigh App Copz2 Copz1 Arf5 Golga2 Asgr2 Asgr1 Pigs B3gnt9 Pigu B3gnt8 Pigt Qtgal Pigo B3gnt6 Pign B3gnt5 Galntl5 Pigz Galnt2 Pigw Galnt5 Pigx Galnt4 Rtn4rl2 Galnt7 Tecta Galnt6 Rtn4rl1 Tectb Galnt10 A4gnt Vcpkmt Cdc25a Sprn Galnt17 Slc35a4 Galnt18 Vcpip1 Galnt15 B3galnt2 Galnt16 Reck Galnt13 Etfb Galnt14 Chst10 Apoa2 Galnt11 Gcnt7 Alg10b Gcnt3 Tmem115 Chst4 Rbx1 Nrn1 Gcnt1 Apoa5 Art4 Art3 Snx3 Bst1 Tmed9 Gpihbp1 Vdac2 Kin Izumo1r Vdac3 Lsamp Tmed3 Copg1 Copg2 Ube2t Vdac1 Negr1 Opcml Large2 Alb Prnd Pcsk9 Copb2 Lypd8 Lypd5 Lypd4 P4hb Lypd3 Lypd2 Copb1 Lypd1 Alpl Plaur Ptp4a2 Sdc2 B4galt4 B4galt5 B4galt6 B4gat1 B4galt1 B4galt2 B4galt3 Bmp4 B3gnt7 B3gnt4 B3gnt2 Rab10 Rab13 Rab14 Kbtbd7 Cul3 Mgat5b Cdc73 Rtf1 Rnf181 Shprh Gpc3 Tmem129 Leo1 Skic8 Selenos Vcan Pex2 Rnf152 Glb1 Rnf40 Pex14 Rnf144a Slc17a5 Pex13 Pex12 Hltf Arsb Pex10 Wac Ctr9 Paf1 Skp2 Pros1 Cdkn1a Ly6e Daxx Gas6 St6galnac6 Smc3 Tnc Nup37 Nup160 Cdc20 Mgat3 Nup43 Rab27a Ranbp2 Rad21 Fbn1 Dync1li2 Dync1li1 Hk1 Alg9 Alg8 Nup107 Alg6 Alg3 Alg2 Dynll1 Alg1 Dynll2 Mpdu1 Rft1 Dpagt1 Stag2 Stag1 Dync1h1 Birc5 Nup85 Cdca8 Incenp Dync1i2 Dync1i1 Aurkb B4galnt2 Sec13 Ano8 St3gal6 Nup133 Traf3 Smc1a Ikbke Hic1 Sp3 Foxl2 Vgf Neurl2 Commd8 Mta1 Commd9 Wsb2 Fem1b Tulp4 Fem1c Dcaf8 Topors Dcaf4 Dcaf5 Dcaf6 Pum2 Ccdc22 Hif3a Dda1 Ccdc8 Fem1aa Commd4 Commd5 Commd6 Commd7 Commd1 Commd2 Commd3 Spsb3 Ankrd9 Galnt1 Commd10 Socs5 Socs6 Ubd Nae1 Wdtc1 Dcun1d5 Cdh2 Dcun1d4 Dcun1d3 Dcun1d2 Fdx1 Dcun1d1 Cul9 Dcaf17 H2ac20 Dcaf10 Dcaf11 Ercc8 Myc Rpn2 Rpn1 Hif1a H2ac12 Cftr H2ac11 H2ac15 Park7 B3gnt3 Axin2 Suz12 Nfkb2 Hist1h2bp Os9 Sel1l Magt1 H2bc9 H2bc7 Dlat H2bc8 H2bc3 Tmem258 Rnf185 Derl2 Serpinc1 Proc Derl1 Ifih1 H2bu2 Mfge8 Rnf135 Trim25 Mavs Stt3a Rigi Stt3b Vcp Rab5a Ostc Rab5c Rab5b Cst3 Cops5 Tusc3 Hist2h2aa1 Dad1 Epas1 Wdr5 Ddost H2bc14 Rnf5 Rhoa H2bc21 H2bc26 Rbbp5 Rbbp7 Lman1 Rab7 Arfgap3 Arf3 Eloc Stx5 Ykt6 Tuba1b Tuba1a Galnt3 Ktn1 Muc15 Tuba1c Muc13 Pomgnt1 Galnt12 Adamts1 Adamts5 Adamts4 Adamts3 Adamts2 Adamts8 Tubb2b Adamts7 Adamts6 Sema5a Tubb2a Sema5b C1galt1 Fbxw10 Thsd1 Actb Thbs2 C1galt1c1 Fbxw4 Thsd4 Fbxw5 Adamts13 Fbxw7 Adamts14 Fbxw9 Adamts15 Large1 Adamts16 Cfp Adamts18 Adamts19 Fbxw2 Spon2 Fstl1 Muc1 Spon1 Adamts10 Sbspon Adamts12 Gmppa B3glct Pmm2 Fbxo4 Muc4 Mpi Muc6 Gmppb Thsd7a Pmm1 Fbxo6 Muc20 Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Pomt1 Tuba3b Adamts20 Thsd7b Dag1 Pomt2 Dcaf7 Tubb6 Tubb3 Trp53 Tubb1 Fbxl3 Cul2 Fbxl5 Tubb4b Tubb4a Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Usp33 Nup42 Nup62 Nup88 Etf1 Aaas Nup214 Nup210 Ckap4 Nup155 Nup153 F2 Amdhd2 Gnpnat1 Srd5a3 Pgm3 St6galnac5 Cmas Dhdds Nudt14 Alg5 Slc35a1 Dolpp1 Fuom Dpm1 Dpm2 Dpm3 Gmds St6gal2 Renbp Eif2ak2 Ctsa Gne St8sia6 St8sia4 St8sia5 Uap1 Dolk Npl Neu2 Neu3 Neu4 Il33 Nagk Fcsk Gfpt1 Gfpt2 Neu1 Dhrsx St6galnac1 Nus1 Slc35c1 Tgfb1 St3gal5 Nanp Fpgt Gfus St8sia2 Kng2 Nans St8sia3 St8sia1 Dnajc3 Parp1 Calr Sqstm1 Arf1 Arfgap2 Canx Ctsz Alg14 Hspa8 Dlst Vnn1 Vnn3 Mat2b Amer1 Tpst1 Tpst2 Riox1 Riox2 Kdm8 Dhps Eif5a Rwdd1 Fn3k Fn3krp Proz F7 Eif5a2 Jmjd4 F9 Jmjd6 Sumf1 Sumf2 Arsa Icmt Fgf23 Dohh Rccd1 Ggcx Dph1 Dph2 Dph3 Dnajc24 Dph5 Dph6 Dph7 Zc3h15 F10 Ogfod1 Arsk Arsj Drg1 Arsi Drg2 Arsg Lrr1 Man1a Man1a2 Fbxl20 Man1c1 Wsb1 Ccnf Rnf123 Rab39b Rab31 Rab32 Rab39 Rab38 Siah2 Keap1 Kbtbd13 Arfgap1 Ube2g2 Ube2g1 Kbtbd8 Rab21 Chml Gan Fbxw8 Klhl9 Klhl2 Fn1 Spsb2 Rab12 Rab18 Spsb1 Lamb2 Spsb4 Ube2j2 Lamc1 Lamb1 Kctd7 Ube2w Ube2m Ube2k Ube2h Ube2f Ube2a Fbxo10 H2-Q10 Fbxo11 Tada3 Fbxo17 Lmo7 Psme4 H2bc18 Psme3 Psme2 Psme1 Lrrc41 Klhl13 Psmd10 Psmb11 Ube2z Psmb10 Klhl11 Pnpla2 Pomp Psmf1 Psmg2 Psmg1 Fbxo21 Psmg4 Becn1 Psmg3 Fbxo22 Psmb9 Psmb8 Psmd9 Psmd5 Psmd4 Fbxo27 Traf6 Ube2v2 Ube2n Uba6 Cdc34 Klhl25 Ube2e3 Ide Tab1 Btbd6 Klhl21 Mitf Klhl22 Klhl20 Fbxl8 Fbxo30 Fbxo31 Fbxl4 Hdac1 Fbxl7 Zbtb16 Uba1 Uba3 Cul5 Actr10 Cul7 Fbxo41 Dctn5 Dctn6 Dctn4 Fbxo44 Capza3 Csf1 Socs2 Klhl41 Klhl42 Fbxo40 Cish Ube2q2 Btbd1 Fbxo2 Asb12 Asb11 Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Herc2 Cga Ube2r2 Rnf7 Fbxo7 Fbxo9 Vhl Fbxl12 Fbxl13 Fbxl14 Fbxl15 Fbxl16 Fbxl18 Fbxl19 Hnrnpk Asb9 Asb8 Asb7 Asb6 Asb5 Asb4 Asb3 Asb2 Cops4 Asb1 Cops2 Hnrnpc Rnf20 Tomm70 Furin Kdelr1 Ctbp1 Tgfbr1 Tgfbr2 Rraga Apc Dnmt3a Dnmt3b Sar1b Dnmt1 Ufd1 Sec23a Nploc4 Mvd Pdia3 Sec24d Sec24c Mbtps1 Sec24b Sec24a Polb Birc3 Birc2 Traf2 Prkn Ube2l3 Nlrp3 Smc6 Smc5 Ripk1 Ddx17 Nsmce4a Casp8ap2 Eid3 Uhrf2 Mrtfa Senp1 Senp2 Nsmce1 Ogt Nsmce3 Nsmce2 Uba2 Sae1 Safb Top2b Top2a Top1 Senp5 Mbd1 Satb1 Nop58 Rnf146 Tnks2 Tnks Trim27 Otud3 Usp13 Ddb1 Wdr48 Ube2b Cul4a Rad18 Cul4b Dtl Camkmt Mul1 Asph Dpp3 Ubxn7 Nsf Gria1 Cdkn2a Il6 Ring1 Cbx8 Phc2 Phc1 Cbx4 Cbx2 Phc3 Mdm2 Mdm4 Ccna1 Ccna2 Bmi1 Igfbp7 Rnf2 Ripk2 Areg Eef2 Adam10 Tnip2 Nod2 Nod1 Usp14 Usp18 C3 C4a Chgb Eva1a Dmp1 Ccn1 Shisa5 Amelx Lgals1 Scg2 Meltf Mxra8 Fam20a Fam20c Fuca2 Stc2 Serpina10 Hrc Alpi Ambn Actr1a Mepe Mia3 Enam Bmp15 Bpifb2 Dctn2 Dctn3 Matn3 Rab11a Rcn1 Vwa1 Fstl3 Prss23 Tmem132a Afp Rab4a Cop1 Igfbp5 Igfbp4 Golm1 Amtn Serpind1 Rab11b Nucb1 Rab33b Sparcl1 Rab33a Msln Itih2 Notum Rab35 Trrap Rab8b Ganab Mgat5 Man2a1 Mgat2 Mgat1 Arf4 Mogs Edem2 Fut8 St6galnac3 St6galnac4 St6galnac2 Syvn1 St3gal4 Mgat4c Mgat4a St3gal2 Mgat4b St3gal1 Man1b1 Prkcsh St6gal1 Kdm1b Csnk1d Rnf103 Amfr Rnf139 Marchf6 Trim13 Uggt1 Uggt2 Edem3 Axin1 Gata3 Ccp110 Gbf1 Cetn2 Rab8a Chm Ing2 Lhb Rab9 Rab43 Kat2b Kat2a Rab9b Cog1 Cog2 Atxn3 Socs3 Cog3 Cog4 Cog6 Cog7 Penk Cog8 Men1 Napa Usp2 Napb Usp7 Napg Rab6b Rab6a Tfap2c Tfap2b Sin3a Pml Ins2 Actl6a Capzb Capza1 Capza2 Timp1 Ddx5 Satb2 Ltbp1 Uchl5 Spta1 Usp15 Usp8 Sptb Ube2d3 Fbxo32 Ank3 Cbx5 Ank1 Sptan1 Sptbn1 Sptbn2 Aurka Trim28 Usp10 Manea Sptbn4 Mdc1 Otulin L3mbtl2 Rce1 Ddb2 Rab3a Nfrkb Usp9x Ino80e Tfpt Ncor2 Ino80d Ino80c Ino80b Actr5 Actr8 Ruvbl1 Pcgf2 Dcaf13 Xpc Spp1 Rad23a Rad23b Cops3 Yy1 Cops6 Cops8 Hipk2 Ino80 Cops7a Cops7b Rabggta Rabggtb Hdac2 Cd109 Hdac7 Clspn Trp53bp1 Abraxas1 Brcc3 Rnf168 Rad52 Babam1 Babam2 Uimc1 Pten H2ac21 Calu Rab27b H2ac25 Hist1h2af Prmt3 Ahsg H2ac1 Spp2 Hsp90b1 Ttll6 Ttll7 Ttll4 Ttll5 Ttll3 Thbs1 Ttll1 Ttl Ttll9 Scg3 Ttll10 Nicn1 Qsox1 Agbl5 Agbl1 Apoe Agbl2 Agbl3 Ttll11 Ttll12 Agtpbp1 Lrrc49 Svbp Vash1 Psma4 Vash2 Foxo4 Aplp2 Prkdc Tpgs1 Psma3 Mmrn1 Tpgs2 Psma6 Psma5 Psma2 Tgfa Psma1 Ikbkg Ctsc Map3k7 Scfd1 Ppp6r1 Psmd12 Ppp6r3 Psmd11 Lman2 Psmd14 Psmd13 Sec22c Smurf2 Sec22b Skp1 Foxk2 Sec22a Tfg Foxk1 Psmb5 Preb Uchl3 Psmb4 Hcfc1 Trappc6b Psmb7 Ppp6c Senp8 Psmb6 Rab2a Trappc9 Asxl1 Psmb1 Trappc6a Uchl1 Psmb3 Trappc5 Mbd6 Psmb2 Trappc4 Asxl2 Fbxw11 Sec31b Trappc3 Rela Sec31a Npm1 Trappc2 Trappc1 Btrc F5 Psma7 F8 Psmc6 Psmc5 Rab1a Psmc2 Stx17 Psmc1 Rab1b Psmc4 Trappc2l Psmc3 Gosr2 Kctd6 Ubc Lman1l Bcl10 Tbc1d20 Psmd7 Cd59b Uso1 Psmd6 Sec23ip Trappc10 Psmd8 Sec16b Psmd3 Sec16a Psmd2 Mcfd2 Psmd1 Lman2l Serpina1d Nfkbia Cnih1 Adrm1 Sem1 Gorasp1 Cul1 Golgb1 Cnih3 Cnih2 Folr1 Ankrd28 Bet1 Nr3c2 Nr3c1 Thrb Nr2c1 Vdr Smad1 Sumo3 Smad2 Nr1h2 Rora Smad3 Ppara Smad4 Esr1 Pparg Pias3 Pias4 Ar Rxra Smad7 Alg11 Hdac4 Ube2i Rara Pgr Nr5a1 Pias1 Nr4a2 Edem1 Dctn1 Pdia6 Chd3 Pcna Kdelr3 Igfbp3 Wfs1 Igfbp1 Blm Bard1 Wrn Palb2 Arrb2 Rpa1 Arrb1 Fga Brca1 Usp30 Fgg Stambpl1 Otud7a Rab22a Gp2 Fuca1 Zranb1 Rhot1 Spaca4 Gcsh Ube2c Ndufab1 Ptrh2 Crppa Cdk1 Abraxas2 Chst8 Ube2d1 Ly6g6c Ly6g6d Wdr20 Ube2e1 Pgap1 Arcn1 Rab42 Stam2 Atxn7 Rab2b Rab30 Rab34 Stam Rab37 Rab36 Usp3 Usp5 Rxylt1 Hgs Cp Ly6k Rab4b Bet1l Rab3c Ntng1 Rab3b Rab3d Tf Ly6h Ly6d Cpm Tex101 Rab20 Cand1 Fkrp Rab24 Rab23 Rab26 Rab25 Rab29 Rab40b Psca Josd2 Rab17 Rab19 Mdga1 Folr2 Mdga2 Pyurf Nfu1 Yod1 Mettl21A Usp21 Fktn Mettl22 Rnf128 Adrb2 Usp4 Nrn1l Cyld Gpaa1 Otud7b Eef2kmt Umod Nedd8 Tnfaip3 Fkbp8 Lias Otoa Mlec Prss21 Prss41 Alppl2 Engase Pomgnt2 Pofut2 Pofut3 Pofut4 Ntm Xpnpep2 Nrip1 Ep300 Stambp Emid1 Copa Cntn3 Cntn5 Lypd6b Xrcc4 Otub1 Bap1 Lipt1 Lipt2 Dbt Usp44 Usp42 Ncoa2 Usp49 Ncoa1 Usp48 Usp47 Cope Otub2 Ngly1 Usp37 Gosr1 Eef1akmt2 Ubxn1 Mysm1 Eef1akmt1 Tnip3 Tnip1 Mmrn2 Usp22 Usp20 Ppargc1a Nfe2l2 Usp26 Usp25 Usp28 Crebbp Pomk Otud5 Col7a1 Apoa1 Usp12 Usp16 Usp19 Apob MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination Mrpl14 Mrps30 Mrpl16 Mrps31 Mrpl17 Mrps33 Mrpl18 Mrpl19 Aurkaip1 Mrps34 Mrps35 Gadd45gip1 Mrpl20 Mrpl3 Mrpl43 Mrpl4 Mrpl44 mt-Co2 Mrpl1 mt-Co3 Mrpl46 Mrpl2 Mrpl47 Mrpl48 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrpl9 Mrps25 Mrps26 Mrps27 Mrps28 Mrps18c Mrps18b Mrps18a Mrpl50 Mrpl51 mt-Cytb Mrpl52 Mrpl53 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrps9 Mrpl36 Mrpl37 Mrpl38 Mrpl39 Mrps10 Mrps11 Mrps12 Mrps14 Chchd1 Mrps15 Mrps16 Mrps17 Ptcd3 Mrps2 Mrps6 Mrps7 ATP6 Mrpl40 Mrpl41 Mrps5 Mrpl21 Mrpl22 Mrpl24 mt-Nd4 Mrpl28 mt-Nd5 Eral1 mt-Nd6 Mrpl30 Gfm2 mt-Nd1 mt-Nd2 mt-Nd3 Mrrf Mtrf1 Mtrf1l mt-Nd4l mt-Co1 Mrpl10 Mrpl54 Dap3 Mrpl11 Mrpl55 Mrpl12 Mrpl13 Mrpl57 Mrpl58 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses Trim25 Mavs Rigi Rbx1 Tyk2 Ubc Ifnar1 Eif2ak2 Irf3 Jak1 Cul5 Ifnb1 Crebbp Stat2 Ep300 Eloc Ifih1 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1483206 Glycerophospholipid biosynthesis Agk Alpi Awat2 Mgll Slc44a3 Pla2g2e Lpin3 Slc44a4 Pla2g2d Gpat2 Slc44a5 Pla2g2f Lpin2 Pla2g4d Lpin1 Ptdss1 Slc44a1 Gpd1l Slc44a2 Ptdss2 Lpcat4 Pld2 Dgat2 Pla2g12a Dgat1 Acp6 Pla2g5 Gpd2 Lclat1 Gnpat Gpat4 Pla2g1b Gpat3 Pla2r1 Liph Pla2g4f Pnpla2 Miga2 Pla2g4c Pla2g4e Agpat5 Pla2g10 Lpcat3 Miga1 Lpcat2 Plbd1 Lpcat1 Plb1 Gpd1 Tmem86b Ddhd1 Pnpla8 Agpat3 Plaat3 Agpat4 Pla2g3 Agpat1 Pla2g6 Agpat2 Mboat2 Ptpmt1 Pisd Pcyt2 Abhd4 Osbpl10 Lpgat1 Pla2g15 Pgp Mboat1 Cpne1 Osbpl5 Cpne3 Pla1a Mfsd2a Phospho1 Osbpl8 Pcyt1b Pgs1 Pcyt1a Dgat2l6 Abhd3 Cpne6 Cpne7 Pemt Selenoi Chpt1 Pld4 Crls1 Pctp Cds2 Hadha Stard10 Cept1 Hadhb Gpcpd1 Chka Pnpla3 Chkb Etnppl Plaat1 Plaat5 Etnk1 Csnk2a2 Tafazzin Ache Bche Chat Pitpnb Csnk2b Cds1 Cdipt Pitpnm3 Pitpnm1 Pla2g4a Mboat7 Stard7 Pld3 Pld1 Gpam PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential Kcnk4 Kcnk3 Kcnk2 Kcnk1 Kcnk7 Kcnk6 Kcnk5 Kcnk12 Kcnk9 Kcnk15 Kcnj4 Kcnj2 Kcnj14 Kcnk13 Kcnk10 Kcnk16 Kcnk18 Kcnj12 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks Kat5 Mre11a Nbn Rad50 Atm INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic Napb Ric1 Stx5 Man2a1 Ykt6 Vti1a Vps45 Trip11 Napg Nsf Rgp1 Stx16 Alppl2 Arf1 Rab33b Rab30 Rab36 Man1a Man1a2 Man1c1 Cux1 Cyth2 Bet1l Cyth3 Gosr2 Golga5 Gosr1 Cyth4 Cyth1 Golim4 Snap29 Cog1 Cog2 Stx6 Cog3 Cog4 Cog6 Rab39 Cog7 Cog8 Napa REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 96%73943 Reversal of alkylation damage by DNA dioxygenases Alkbh5 Fto Alkbh3 Ascc1 Ascc3 Ascc2 Alkbh2 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling Pik3ca Nrg3 Ereg Hbegf Btc Nrg1 Pik3r1 Nrg2 Nrg4 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 96%9861559 PDH complex synthesizes acetyl-CoA from PYR Pdhx Pdha1 Pdha2 Dld Dlat Pdhb SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.5 Surfactant metabolism Gata6 Slc34a2 P2ry2 Adora2b Csf2rb2 Csf2ra Sftpc Ttf1 Abca3 Sftpb Ctsh Adgrf5 Sftpd Dmbt1 Zdhhc2 Adra2a Sftpa1 Ckap4 Adora2a Adra2c Lmcd1 Napsa Slc34a1 Ccdc59 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) Idua EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects Cdkn2a Cdk6 Cdk4 MATURATION OF REPLICASE PROTEINS%REACTOME%R-HSA-9694301.5 Maturation of replicase proteins Iscu CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9603798 Class I peroxisomal membrane protein import Pex26 Abcd1 Pex11b Pex3 Slc25a17 Gdap1 Acbd5 Abcd2 Abcd3 Pxmp4 Pex19 Pxmp2 Pex2 Atad1 Fis1 Pex14 Pex16 Pex13 Pex12 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME%R-HSA-9726842.2 Gain-of-function MRAS complexes activate RAF signaling Ppp1cc Shoc2 Mras Braf Ywhab Ppp1cb Araf Raf1 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022923 DS-GAG biosynthesis Ncan Bgn Cspg5 Ust Cspg4 Dcn Bcan Vcan Chst14 Dsel Chst15 Dse SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma Hpx Hbbt1 Ambp Hp Jchain Alb Cd163 Lrp1 Apoa1 Hba-a1 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 96%109606 Intrinsic Pathway for Apoptosis Apaf1 Apip Ppp3r1 Mapk8 Cdkn2a Stat3 Bcl2l11 Trp63 Ywhae Xiap Bid Gzmb Tfdp2 Tfdp1 Bak1 Casp3 Casp8 Gsdme Ppp1r13b E2f1 Gsdmd Mapk1 Bax Mapk3 Ywhab Ywhag Aven Uaca Trp73 Diablo Trp53 Casp7 Trp53bp2 Ywhah Bcl2 Akt3 Akt2 Bcl2l1 Akt1 Dynll1 Dynll2 Ywhaz Casp9 Bad C1qbp Nmt1 Sfn Bmf Ppp3cc CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Eif2b3 Eif2b2 Rpl39l Eif2b5 Rps15a Eif2b4 Eif2s3x Eif2b1 Eif2s2 Eif2s1 Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Eif4ebp1 Eif4g1 Eif3m Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Pabpc1 Eif3g Eif3b Eif3a Eif3d Eif3c Eif4h Eif3j2 Eif4b Eif4e Eif1ax Eif4a2 Eif4a1 Rps27 Rps14 Rpl4 Eif5b Rps16 Eif5 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9920951 Dengue virus modulates apoptosis Taok1 Pik3c3 Mlst8 Ripk1 Mtor Retreg1 Nfkbib Daxx Becn1 Pik3r4 Prr5 Rictor Nfkbia Rptor Mapkap1 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811434 COPI-dependent Golgi-to-ER retrograde traffic Arfgap1 Kdelr2 Gbf1 Kif18b Use1 Kif26b Kifc2 Kif12 Nsf Kif21a Kif1c Kif21b Kif13b Kif1a Copz2 Kif1b Copz1 Bnip1 Arf5 Kif6 Kif9 Stx18 Kif27 Rint1 Kif16b Kif20b Kif19a Surf4 Cenpe Sec22b Arf1 Arfgap2 Arcn1 Rab1a Rab1b Tmed9 Tmed3 Copg1 Copg2 Kif3a Kdelr1 Kif3b Copb2 Kif3c Kif5b Zw10 Kif4 Copb1 Napa Napb Napg Arf4 Kif2a Kif2b Kif2c Racgap1 Kif26a Kif11 Kif15 Copa Kif22 Kif23 Kif18a Arfgap3 Kif20a Kdelr3 Arf3 Klc1 Klc4 Klc3 Klc2 Cope Kifap3 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins Scn7a Scn11a Scn3a Scn3b Nfasc Scn8a Nrcam Scn4a Sptbn1 Scn4b Sptbn2 Sptbn4 Spta1 Scn9a Scn5a Sptb L1cam Scn1a Scn1b Kcnq3 Kcnq2 Ank3 Ank1 Scn10a Scn2a Scn2b Sptan1 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gja1 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380320 Recruitment of NuMA to mitotic centrosomes Prkaca Ccp110 Alms1 Cetn2 Tubgcp2 Numa1 Nedd1 Tubg2 Actr1a Nme7 Tuba1a Tubgcp5 Tubgcp4 Tubgcp3 Cep43 Mzt1 Dctn2 Mzt2 Cep41 Dctn3 Plk1 Ninl Ywhae Cdk1 Nek2 Pcnt Tuba4a Cep250 Sdccag8 Cep78 Cep76 Cep72 Cep70 Tubb5 Plk4 Cpap Clasp1 Ywhag Pafah1b1 Cep135 Cep131 Prkar2b Csnk1e Tubb4b Haus7 Tubb4a Haus8 Cdk5rap2 Cep57 Pcm1 Mapre1 Dynll1 Ssna1 Tubg1 Ppp2r1a Ofd1 Dync1h1 Cep63 Cep152 Haus3 Haus4 Haus5 Haus6 Sfi1 Dync1i2 Csnk1d Haus1 Ckap5 Haus2 Akap9 Hsp90aa1 Cep164 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels Kcnk4 Kcnk3 Kcnk2 Kcnk13 Kcnk1 Kcnk10 Kcnk16 Kcnk7 Kcnk6 Kcnk18 Kcnk9 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 96%5693538 Homology Directed Repair Xrcc1 Lig3 Ubc Sem1 Ube2n Ube2v2 Pias4 Ube2i Kat5 Lig1 Exo1 Eme1 Mus81 Nbn Gen1 Rfc5 Pold2 Pold1 Rfc3 Pcna Sirt6 Rfc4 Fignl1 Mdc1 Rfc1 Rfc2 Pold4 Pold3 Hus1 Atrip Brip1 Dna2 H2ax Pole3 Rad51c Rad51d Pole2 Blm Rad51b Chek1 Pole4 Rad9a Hist1h2bp Bard1 Rad9b Top3a Slx4 Wrn Mre11a Herc2 Spidr Palb2 Rad51 Rad50 Firrm Rpa1 Rnf4 Topbp1 Rpa2 Rad17 Rbbp8 Rtel1 Brca2 Brca1 Xrcc3 Rad51ap1 Xrcc2 H2bc9 Rpa3 H2bc7 Polk H2bc8 Rad1 Atm H2bc3 Polh Parp2 Pole Parp1 H3c8 Ercc1 Ercc4 H2bu2 Cdk2 Ccna1 Ccna2 Fen1 H2bc14 H2bc21 Ppp4r2 H2bc26 Timeless Tipin Abl1 Ppp4c Clspn Trp53bp1 Abraxas1 Brcc3 Rnf168 Nsd2 Rad52 Babam1 Babam2 Uimc1 Polq PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism Mcee Pcca Mmaa Pccb Mmut DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation Hgf Met MATURATION OF HRSV A PROTEINS%REACTOME DATABASE ID RELEASE 96%9828806 Maturation of hRSV A proteins Ppp1cc Xpo1 Csnk2a2 Spcs3 Spcs1 Spcs2 Furin Ppp1ca Kpnb1 Ppp1cb Sec11c Csnk2b Sec11a PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 Plk1 Fzr1 Cdk1 Fbxo5 Cdc20 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery Supt5h Ell Nelfa Nelfb Nelfe Ctdp1 Ccnk Polr2c Polr2d Polr2a Polr2b Supt4h1a Polr2g Tcea1 Polr2h Nelfcd Polr2e Supt16 Polr2f Cdk9 Polr2k Ccnt2 Ssrp1 Polr2i Ccnt1 Polr2j Eloa Gtf2f2 Eloc Gtf2f1 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production Nsmaf Rack1 Tnf Tnfrsf1a Smpd2 Smpd3 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8963693 Aspartate and asparagine metabolism Slc25a12 Aspa Slc25a13 Nat8l Got1 Got2 Asns Gadl1 Naalad2 Aspg SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription Sp1 Ybx1 Smad2 Tgif1 Smad3 Tgif2 Smad4 Rnf111 Hdac1 Smad7 Myc Cdkn2b Junb Rbl1 Ep300 Cdk8 Tfdp2 Tfdp1 Ccnk E2f4 E2f5 Ubc Wwtr1 Serpine1 Mapk1 Mapk3 Furin Col1a2 Cdk9 Ccnt2 Ccnc Ccnt1 Men1 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation Jak2 Jak1 Il6ra Mapk3 Map2k1 Cdk1 Tyk2 Il6 Ptpn11 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 96%442982 Ras activation upon Ca2+ influx through NMDA receptor Actn2 Nefl Grin1 Dlg1 Grin2d Dlg3 Nras Dlg4 Camk2g Hras Camk2d Grin2b Camk2b Camk2a Rasgrf1 Rasgrf2 Dlg2 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Cdkn2a Cdk4 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere Pcna Rpa2 Acd Pold4 Pold3 Rpa3 Dna2 Terf2ip Tinf2 Blm Terf2 Terf1 Lig1 Wrn Fen1 Pot1 Pold2 Pold1 Rpa1 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation Mylip Ap2a2 Ap2a1 Nr1h2 Ap2b1 Ubc Ap2s1 Clta Ap2m1 Cltc Nr1h3 Pcsk9 Vldlr LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis Cd3g Elmo2 Vav2 Cyfip1 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Btk Actg1 Actb Myo5a Arpc3 Arpc2 Cyfip2 Arpc5 Arpc4 Mapk1 Fcgr4 Syk Ptk2 Mapk3 Fgr Myh2 Brk1 Myo1c Nckipsd Was Wasf3 Baiap2 Nckap1l Wasl Myo10 Crk Nckap1 Nck1 Fyn Wasf2 Wasf1 Abl1 Abi2 Myo9b Abi1 Lyn Yes1 Myh9 Rac1 Vav1 Elmo1 Hck Vav3 Dock1 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 96%9665233 Resistance of ERBB2 KD mutants to trastuzumab Erbb2 Cdc37 Erbin Hsp90aa1 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs Ltc4s Ephx2 Cyp1a2 Alox12 Hpgd Alox5 Lta4h Ptgs2 Cyp2d22 Alox15 Cyp3a16 Cyp2c65 Gstm4 Cyp2e1 Cyp1a1 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 96%9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination Cyp51a1 Srebf2 Egr2 Hdac2 Pmp22 Mag Adgrv1 Hmgcr Tead1 Nab1 Nab2 Lama2 Lamc1 Lamb1 Smarca4 Adgrg6 Utrn Mbp Pou3f2 Sox10 Prx Pou3f1 Wwtr1 Drp2 Mpz Dag1 Yap1 SIGNALING BY ALK%REACTOME%R-HSA-201556.5 Signaling by ALK Frs2 Irs1 Cd274 Jak3 Plcg1 Ptpn6 Hdac2 Mdk Hdac1 Myc Alk Ptprz1 Stat3 Il2rg Hif1a Mycn Ep300 Ptn Prdm1 Sin3a Alkal1 Hdac3 Dnmt1 Pik3cb Pik3ca Pik3r1 Pik3r2 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants Ppp2cb Ppp2ca Gsk3b Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles Psip1 Hmga1 Banf1 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%73854 RNA Polymerase I Promoter Clearance H2bc9 H2bc7 H2bc8 H2bc3 Gatad2a Gatad2b Ehmt2 H2ab2 Polr1c Mbd3 Polr1d H2bu2 Mta1 Mta3 Ttf1 Polr1b Polr1a Polr1g Kat2b Polr1e Polr1h Kat2a Taf1d Polr2h Hist2h2aa1 Mapk3 Taf1a Polr2e Taf1c Polr2f Taf1b Polr2k Mnat1 Cbx3 Ubtf Gtf2h2 Gtf2h1 Gtf2h4 Gtf2h3 Gtf2h5 Ercc2 Ccnh Ercc3 Mbd2 Cdk7 H2bc14 H2ac20 Hdac2 Hdac1 H2bc21 H2bc26 Rbbp4 Rbbp7 Chd3 Chd4 H2ac12 H2ac11 Rrn3 Ercc6 H2ac15 Tbp H3c7 H2ax Mta2 Hist1h2bp H2aj CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 96%5607764 CLEC7A (Dectin-1) signaling Nfatc1 Nfatc3 Nfatc2 Itpr3 Itpr2 Itpr1 Ppp3r1 Ppp3ca Ppp3cb Psma4 Ikbkb Psma3 Psma6 Plcg2 Psma5 Psma2 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Map3k14 Psmd14 Psmd13 Nfkb1 Skp1 Malt1 Ube2d1 Psmb5 Ube2m Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Card11 Btrc Psma7 Psmc6 Psmc5 Casp8 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Bcl10 Psmd7 Psmd6 Il1b Syk Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Pdpk1 Adrm1 Sem1 Traf6 Cul1 Ube2n Chuk Pycard Cdc34 Ube2v1 Tab3 Tab2 Tab1 Relb Uba3 Clec7a Prkcd Card9 Ahcyl1 Nfkb2 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 96%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation Gch1 Nos3 Akt1 Dhfr Pts Gchfr Hsp90aa1 Prkg2 Spr REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%9022692 Regulation of MECP2 expression and activity Prkaca Hdac2 Hdac1 Foxg1 Ncor2 Tnrc6c Htt Ncor1 Tnrc6a Tnrc6b Camk4 Tbl1x Mov10 Hipk2 Sin3a Ago4 Ago3 Hdac3 Ago2 Ago1 Gps2 Lbr Tbl1xr1 Camk2g Camk2d Camk2b Camk2a Aurkb NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway Ube2v1 Tab3 Tab2 Tab1 Cyld Ikbkb Tnfaip3 Mapk11 Birc3 Birc2 Ripk2 Ikbkg Map3k7 Aamp Casp9 Nod2 Nod1 Itch Card9 Casp8 Casp4 Casp1 Irak2 Casp2 Mapk12 Irak1 Mapk13 Traf6 Ube2n Mapk14 Chuk Map2k6 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020958 Interleukin-21 signaling Stat3 Jak1 Stat1 Il2rg Stat4 Jak3 Stat5a Stat5b Il21 Il21r COBALAMIN (CBL) METABOLISM%REACTOME%R-HSA-9759218.2 Cobalamin (Cbl) metabolism Mtrr Mmab Mmadhc Mtr Mmachc Mmaa Mmut SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses Mbl2 Larp1 Sting1 Tyk2 Irf7 Ikbkb Nup133 Ifnar1 Traf3 Ikbkg Map3k7 Ikbke Stat2 Nlrp3 B2m H2-Q10 Becn1 Irak1 Traf6 Ube2n Chuk Ube2v1 Tab3 Tab2 Tab1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Il17rc Il17ra Jak1 Hsp90aa1 Isg15 Stat1 Tlr1 Tlr2 Sftpd Hsp90ab1 Ifih1 Sike1 Rnf135 Trim25 Mavs Rigi Tomm70 Ifnb1 Nup37 Nup160 Nup43 Pik3c3 Ranbp2 Ptpn6 Nlrp12 Ptpn11 H2-M5 H2-M3 Ripk2 Tbk1 Nup107 G3bp1 G3bp2 Irf3 Pik3r4 H2-Q1 Nod2 Nod1 Cnbp Sar1b Sec23a Tkfc Nup85 Irak2 Il17f Tlr8 Il17a Tlr7 Sec24d Sec24c Crebbp Sec24b Sec13 Sec24a SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate Srd5a3 Dhrsx Nus1 Dhdds Dolk Dolpp1 Mvd CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-HSA-5607763.3 CLEC7A (Dectin-1) induces NFAT activation Nfatc1 Nfatc3 Itpr3 Nfatc2 Itpr2 Itpr1 Ppp3r1 Ppp3ca Ppp3cb Ahcyl1 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels Gng10 Kcnj3 Kcnj2 Gng3 Gng2 Gng4 Gng7 Gng8 Gabbr1 Gabbr2 Gngt1 Gngt2 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Gnb2 Gnb1 Kcnj10 Gnb4 Gnb3 Gnb5 Gng11 Kcnj12 Gng12 Gng13 Kcnj15 Kcnj16 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 96%69002 DNA Replication Pre-Initiation Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 H2ac20 Kpna1 H2ac12 H2ac11 Orc5 Orc4 Orc6 Orc1 H2ac15 Mcm8 Orc3 H3c7 Orc2 H2ax Pole3 Pole2 Pole4 Hist1h2bp H2aj Kpnb1 Rpa1 Rpa2 H2bc9 Rpa3 H2bc7 H2bc8 Cdc7 H2bc3 Pole Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 H2ab2 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 H2bu2 Anapc15 Fzr1 Mcm7 Cdk2 Mcm3 Mcm4 Mcm5 Mcm6 Cdc45 Mcm2 Hist2h2aa1 Cdt1 Gmnn Kpna6 Dbf4 Mcm10 H2bc14 Cdc6 H2bc21 H2bc26 Prim2 Prim1 Pola2 Pola1 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 Fgf16 Fgf23 Fgf18 Fgf2 Fgf1 Fgf4 Fgf9 Fgfr3 Fgf20 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins Ccdc88c Dvl1 Dvl2 Dvl3 CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli Sp1 Tlr4 Dnaja2 Prdx2 Jun Prdx1 Capn2 Sod2 Ywhae Capns1 Capns2 Foxo3 Prkacb Lmnb1 Nlrp3 Adcy3 Notch1 Adcy4 Rbx1 Adcy1 Adcy2 Creb3l3 Adcy7 Adm Adcy8 Adcy5 Adcy6 Yme1l1 Adcy9 Il1a Phb2 Alb Stoml2 Calcrl Prkar1b P4hb Idh1 Prkar2b P2rx7 Gng10 Hspa9 Gng3 Gng2 Hspg2 Gng4 Gng7 Gng8 Gngt1 Gngt2 Stap2 Aqp8 Ero1a Prdx3 Camk2g Mul1 Abcc3 Camk2d Atf4 Sesn1 Camk2b Dpp3 Mafg Camk2a Ramp2 Gclc Gclm Gnb2 Prdx6 H13 Gnb1 Me1 Gnb4 Gnb3 Abcf2 Gnb5 Txnrd2 Gpx3 Gng11 Gpx6 Txn2 Gpx5 Gng12 Gpx8 Gng13 Blvrb Gpx7 Prkaca Blvra Chd6 Gsta3 Ccl12 Nudt2 Srxn1 Nqo1 Tkt Ubxn7 Mapk9 Sod3 Mapk7 Ccs Atox1 Mapk8 Ets1 Map3k5 Cul3 Ets2 Tinf2 H1f2 H1f3 Tnik Cdkn2a Cdkn2b Cdkn2c Hira Ehmt2 Erf Ehmt1 H3c8 Txn Map4k4 Kdm6b Cabin1 Il6 Ring1 Cbx8 Phc2 Ccne1 Cbx6 Phc1 Ccne2 Acd Fzr1 Cbx4 Tfdp2 Cbx2 H1-1 Nrf1 Tfdp1 H1-0 Skp2 Lonp1 Asf1a Dele1 Rb1 Phc3 Htra2 Terf2ip Dnaja4 H1-5 Extl2 Dnaja1 H1-4 Cdk6 Cdk4 Mdm2 Cdk2 Hmga2 Mdm4 E2f1 Extl3 E2f2 Ccna1 E2f3 Hspa5 Ccna2 Terf2 Cdkn1a Terf1 Ep400 Cdkn1b Bmi1 Ifnb1 Igfbp7 Rps6ka3 Abcc1 Mink1 Pgd Rps6ka2 Pot1 Nup37 Map2k7 Nup160 Cebpb Map2k6 Rnf2 Ubn1 Cdh5 Ppp2ca Mapkapk5 Map2k4 Nup43 Map2k3 Mapk10 Ranbp2 Dync1li2 Prkci Egf Dync1li1 Bcl2 Pdgfa Nup107 Bcl2l1 Areg Dynll1 Dynll2 Rps27 Atf6 Ppp2r1b Ppp2r1a Dync1h1 Hspa1l Nup85 Egln2 Egln3 Hif1an Wtip Dync1i2 Limd1 Dync1i1 Taldo1 Ppp2r5b Lmna Atp7a Sec13 Hspa2 Actr1a Flt4 Dctn2 Dctn3 Nup133 Eif2s3x Eif2s2 Eif2s1 Ikbke Fbxl17 Slc7a11 Hif3a Gsk3a H2ac20 Syvn1 Trib3 Prkaa2 Myc Nos3 Akt3 Akt2 Akt1 Atf3 Prkar1a Eif2ak3 Hif1a Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago1 H2ac15 H3c7 Mt2 Ezh2 Mt1 H2ax Mt4 Mt3 Csnk2a2 Suz12 Exosc9 Exosc8 Exosc5 Hist1h2bp Dis3 Fos Exosc4 Exosc7 Ddit3 Exosc6 H2aj Txnip Parn Exosc1 Exosc3 Exosc2 Pik3r2 Yap1 Higd1c Cited2 H2bc9 H2bc7 H2bc8 H2bc3 mt-Co2 mt-Co3 Stat3 Stat1 Rictor H2ab2 H2bu2 Vcp Pik3cb Pik3cd Pik3ca Hist2h2aa1 Prr5 Pdpk1 Epas1 Csnk2b Eed Gsk3b Mlst8 Sesn2 Coxfa4 H2bc14 Itga5 Mtor Fyn H2bc21 Tnrc6c H2bc26 Rbbp4 Abl1 Rbbp7 Tnrc6a Tnrc6b Mapkap1 Ajuba Sin3a Gpx2 Itgb1 Ptpn1 Cacna1h Cox7a1 Cox7a2 Dcp2 Eloc Cox7a2l Capzb Gja1 Capza1 Capza2 Acadvl Nox4 Mmp14 Fabp1 Fkbp5 Fkbp4 Vegfa Eif2ak4 Fnip1 Samtor Gna11 Szt2 Itfg2 Gcn1 Nprl3 Nprl2 Wdr59 Ube2d3 Mios Depdc5 Kptn Itgav Impact Ppp2r2a Castor1 Ptk2 Kics2 Wdr24 Anxa2 Gnaq Flcn Sh3bp4 Dnajc7 Hsph1 Dnajc2 Cryab Hikeshi Trp53 Hspa14 Hspa13 Rps19bp1 Hsbp1 Cul2 St13 Hspa12b Hspa12a Bag5 Nup93 Bag4 Hsf1 Nup50 Bag3 Nup35 Bag1 Nup54 Hspb8 Pom121 Nup205 Dnajb6 Nup188 Dnajb1 Tpr Hspa4l Rae1 Hspa4 Ndc1 Ccar2 Nup42 Nup62 Nup88 Aaas Chac1 Nup214 Nup210 Nup155 Nup153 Prkar2a Hmga1 Panx1 Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Cacna2d1 Rps11 Rpl7 Hsp90aa1 Rpl32 Cacnb3 Rps9 Rps7 Cacnb1 Rps5 Gfpt1 Rpl24 Cacnb2 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Eif2ak1 Atf5 Rpl39l Rps15a Ncor2 Dnajc3 Calr Rps27l Rplp2 Rpl22l1 Spp1 Sqstm1 Rplp1 Rpl13a Rpl18a Hspa1a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Cox6a1 P2ry2 Rps4x Cox6a2 Hspa8 Amer1 Cox6b1 Cox6b2 Hdac6 Oma1 Arnt G6pdx Prkcd Hsp90b1 Trpv4 Keap1 Arfgap1 Cox8a Grb10 Cox7b Pecam1 Psma4 Ikbkb Psma3 Psma6 Psma5 Psma2 Psma1 Ikbkg Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Psmb5 Preb Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Cox5a Psmb2 Rela Sec31a Btrc Psma7 Psmc6 Psmc5 Stip1 Psmc2 Psmc1 Psmc4 Psmc3 Gosr2 Ubc Psmd7 Psmd6 Map1lc3b Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Cul1 Chuk Sirt3 Nr3c2 Nr3c1 Rora Ppara Esr1 Ar Add1 Rxra Mydgf mt-Co1 Extl1 Csrp1 Pgr Srprb Txnrd1 Sncb Srpra Asns Yif1a Cox4i1 Edem1 Actr10 Cul7 Kat5 Cox4i2 Dctn5 Herpud1 Hspd1 Dctn6 Dctn1 Ddx11 Dctn4 Rps6ka1 Nbn Cxxc1 Capza3 Pdia6 Pdia5 Creb3 Dcstamp Ern1 Klhdc3 Serp1 Cebpg Cat Creb3l4 Creb3l1 Id1 Creb3l2 Kdelr3 Tspyl2 Fkbp14 Atf6b Ssr1 Hyou1 Hdgf Wipi1 Wfs1 Tatdn2 Igfbp1 Crebrf Dnajb9 Zbtb17 Tpp1 Dnajb11 Mre11a Palb2 Bag2 Rad50 Rpa1 Rpa2 Trim21 Vhl Brca1 Pkn2 Rpa3 Itgb3 Atm Tln1 Vcl Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Hsp90ab1 Cdc23 Anapc15 Atp6v0b Ctnnb1 Atp6v1g3 Hmox2 Atp6v0e2 Atp6v1c2 Kdr Atp6v1c1 Ptk6 Shc1 Mapk1 Mapk3 Abcg2 Ncf1 Ncf2 Ncf4 Rptor Mapkapk3 Atp6v1e2 Atp6v1e1 Mapkapk2 Mapk14 Tcirg1 Slc38a9 Atp6v1a Atp6v1b2 Lamtor5 Akt1s1 Atp6v0d2 Lamtor4 Atp6v0d1 Rraga Atp6v1b1 Rragb Atp6v0e1 Atp6v1g2 Lamtor1 Atp6v1g1 Rragc Lamtor2 Rragd Atp6v1f Atp6v1d Mapk11 Atp6v1h Ncor1 Atf2 Slc46a1 Helz2 Cyba Carm1 Nrip1 Ep300 Tbl1x Cybb Hmox1 Mef2d Epo Clock Car9 Clec1b Bmal1 Crtc3 Hdac3 Crtc2 Rai1 Ncoa2 Ncoa1 Xpo1 Ufd1 Tbl1xr1 Smarcd3 Mtf1 Nploc4 Crtc1 Ncoa6 Hba-a1 Cacng7 Mafk Hbbt1 Npas2 Med1 Bach1 Nfyb Nr1d1 Pgrmc2 Nfya Nfyc Ppargc1a Nfe2l2 Ly96 Mbtps1 Crebbp Mef2c Mbtps2 Apoa1 Chd9 Sirt1 Apob OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956522 OTC variants cause OTC deficiency Otc VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.3 Vif-mediated degradation of APOBEC3G Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Cul5 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Eloc ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-6807062.4 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) Cyp51a1 Srebf1 Srebf2 Tm7sf2 Hsd17b7 Nsdhl Dhcr24 Msmo1 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression Gata4 Hipk1 Hipk2 Tbx5 Nppa Tead4 Kat2b Tead3 Tead2 Wwtr1 Tead1 Ccn2 Nkx2-5 Yap1 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 96%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 Psma4 Psma3 Psma6 Psma5 Plk1 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdc27 Ube2d1 Psmb5 Cdc16 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Psmb2 Fzr1 Skp2 Psma7 Psmc6 Rb1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cdc20 Aurka Pttg1 Aurkb PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis Ppat Impdh1 Gmps Paics Gart Atic Adsl Adss2 Pfas Adss1 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 96%8851680 Butyrophilin (BTN) family interactions Btnl2 Cd209a Ppl Btn1a1 Btnl9 Btn2a2 Xdh HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 96%5610787 Hedgehog 'off' state Prkaca Ift172 Psma4 Psma3 Wdr19 Psma6 Psma5 Psma2 Psma1 Rpgrip1l Psmd12 Ift88 Psmd11 Psmd14 Psmd13 Skp1 Gli3 Psmb5 Prkacb Gli2 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Itch Adcy3 Btrc Adcy4 Rbx1 Psma7 Adcy1 Psmc6 Adcy2 Psmc5 Adcy7 Psmc2 Ift140 Adcy8 Psmc1 Adcy5 Psmc4 Adcy6 Psmc3 Ubc Gpr161 Adcy9 Psmd7 Gli1 Psmd6 Numb Intu Tulp3 Adcy10 Psmd8 Psmd3 Kif3a Fuz Psmd2 Psmd1 Adrm1 Sem1 Cul1 Smo Prkar1b Prkar2b Gsk3b Mks1 Ift52 Csnk1a1 Ttc21b Ift57 Ptch1 Prkar1a Ift122 Ofd1 Prkar2a Wdr35 Sufu Dync2h1 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 96%168276 NS1 Mediated Effects on Host Pathways Nup43 Mlkl Ranbp2 Kpna4 Nup93 Kpna7 Nup50 Nup35 Kpna3 Nup54 Cpsf4 Pom121 Nup205 Nup133 Isg15 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Kpna1 Aaas Nup214 Nup210 Nup155 Nup153 Pabpn1 Nup85 Eif2ak2 Kpnb1 Nup37 Sec13 Nup160 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 96%8942233 Intestinal infectious diseases Gucy2c Nherf4 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.4 Truncations of AMER1 destabilize the destruction complex Ppp2cb Ppp2ca Gsk3b Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Prkaca Pecam1 Pkn2 Flt4 Tln1 Vcl Mmp14 Capn2 Rictor Capns1 Capns2 Prkacb P2ry2 Ctnnb1 Adcy3 Adcy4 Gna11 Adcy1 Adcy2 Adcy7 Pik3cb Adm Adcy8 Pik3cd Adcy5 Adcy6 Kdr Pik3ca Adcy9 Gnaq Prr5 Pdpk1 Calcrl Prkar1b Cdh5 Prkar2b Mlst8 Gng10 Mtor Fyn Nos3 Gng3 Akt1 Gng2 Prkar1a Gng4 Gng7 Mapkap1 Gng8 Prkar2a Gngt1 Gngt2 Panx1 Ramp2 Gnb2 Gnb1 Gnb4 Trpv4 Gnb3 Gnb5 Gng11 Pik3r2 Gng12 Gng13 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport Rhag Rhcg Rhbg B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression Gsk3b Sf3b1 H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 H2bc3 H2bc21 H2bc26 H2ab2 Polr1c Ep300 Dek Actb Polr1d Baz1b H2bu2 H2ac12 H2ac11 Ercc6 H2ac15 Tbp Smarca5 H3c7 H2ax Polr1b Polr1a Kat2b Polr1g Polr1e Polr1h Hist1h2bp Kat2a Taf1d Polr2h Hist2h2aa1 Taf1a Polr2e Taf1c Polr2f Taf1b Polr2k H2aj Mybbp1a Ddx21 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI Cyp24a1 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells Pbx1 Fgf2 Smad2 Smad4 Sox2 Zic3 Sall4 Epha1 Pou5f1 Sall1 Hif3a Stat3 Nr5a1 Foxd3 Klf4 Lin28a Epas1 Prdm14 Zscan10 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9818749 Regulation of NFE2L2 gene expression Mafk Myc Rela Notch1 Nfe2l2 Nfkb1 Crebbp Ep300 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants Neurl1a Dll1 Mib1 Notch1 Dll4 Jag2 Jag1 Adam10 Neurl1b Ubc Mib2 Adam17 DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196854 Metabolism of vitamins and cofactors Pnlip Apoe Nt5e Cyb5a Slc23a1 Cyb5r3 Slc23a2 Ldlrap1 Amn Lrp1 Lrp2 Bco2 Bco1 Apoa2 Ldlr Apoa4 Bst1 Lpl Gpihbp1 Apoc2 Plb1 Akr1c21 Apoc3 Parp14 Parp16 Akr1c6 Tcn2 Cubn Parp4 Idh1 Parp6 Parp8 Parp10 Parp9 Prkg2 Apom Nos3 Retsat Akt1 Dhfr Hspg2 Sdc4 Sdc3 Sdc2 Gsto2 Nampt Sdc1 Akr1b10 Ttpa Hsp90aa1 Lmbrd1 Pcx Abcd4 Lrp10 Gpc1 Lrp12 Gpc3 Gpc2 Gpc5 Gpc4 Pcca Mmaa Gpc6 Pccb Mmut Mmab Ttr Mmadhc Mmachc Rbp4 Rbp2 Slc5a6 Rbp1 Pdzd11 Aasdhppt Enpp1 Nnmt Enpp2 Prss2 Mtrr Enpp3 Pank3 Agrn Pank2 Mtr Pank4 Mccc1 Vnn1 Slc25a16 Vnn3 Gsto1 Abcc1 Mccc2 Ppcs Pank1 Fasn Dcakd Shmt1 Ppcdc Pdxk Slc25a42 Slc52a2 Coasy Naxe Slc52a3 Folr2 Ubiad1 Lrat Btd Ctrb1 Slc25a51 Cd320 Slc19a1 Slc19a2 Slc5a8 Cblif Mthfr Vkorc1 Slc25a32 Thtpa Mthfd1l Naprt Rfk Slc2a3 Acp5 Aox1 Nadk2 Nudt12 Mthfd2l Nmrk2 Slc46a1 Nmrk1 Mocs3 Slc25a19 Mocs2 Aldh1l1 Hlcs Rdh11 Slc2a1 Nadsyn1 Aldh1l2 Gch1 Shmt2 Pdss2 Cd38 Akr1c18 Coq8a Pnpo Coq8b Nadk Pdss1 Nmnat1 Coq2 Flad1 Coq3 Slc22a13 Pts Vkorc1l1 Gchfr Nmnat3 Coq4 Nmnat2 Coq5 Tpk1 Coq6 Mthfsl Hpdl Qprt Coq7 Mthfd1 Spr Mthfd2 Coq9 Gphn Acacb Stard7 Mocos Acaca Apoa1 Clps Apob TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9703009 tamatinib-resistant FLT3 mutants Flt3 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated Ppp2cb Ppp2ca Gsk3b Ctnnb1 Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function Lrat Rbp1 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%71737 Pyrophosphate hydrolysis Ppa1 Lhpp Ppa2 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 96%3296482 Defects in vitamin and cofactor metabolism Mmab Btd Mmadhc Mmachc Cd320 Pcx Abcd4 Cblif Acaca Mtrr Amn Mtr Mccc1 Pcca Mccc2 Mmaa Lmbrd1 Pccb Mmut Tcn2 Hlcs Cubn INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria Hbbt1 Gbp9 Upk1a Epcam Casp4 Gbp2 Gbp3 Ubc Hba-a1 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5682910 LGI-ADAM interactions Cacng8 Cacng4 Cacng2 Cacng3 Dlg4 Lgi2 Stx1b Lgi3 Lgi4 Lgi1 Adam23 Adam11 Adam22 Stx1a MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9715370 Miro GTPase Cycle Rhot1 Rhot2 Rap1gds1 Mfn1 Mfn2 Trak2 Trak1 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling Casp8 Cflar Tnfsf10 Tnfrsf10b Fadd BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression Ppara F7 Rxra Helz2 Carm1 Tbl1x Clock Bmal1 Avp Nampt Ncoa2 Ncoa1 Tbl1xr1 Smarcd3 Ncoa6 Npas2 Serpine1 Med1 Crebbp Bmal2 Bhlhe40 Bhlhe41 Chd9 Noct Klf15 CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 96%5690714 CD22 mediated BCR regulation Cd79a Cd22 Cd79b Ptpn6 Lyn REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors Akt3 Akt2 Akt1 Sfn Ywhab Ywhag Foxo4 Foxo3 Ywhaz Foxo1 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 96%5578768 Physiological factors Npr1 Gata4 Hipk1 Npr2 Hipk2 Corin Nppc Tbx5 Nppa Kat2b Wwtr1 Ces1d Mme Nkx2-5 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764302 Regulation of CDH19 Expression and Function Jup Ctnnb1 Cdh19 Ctnna1 Sox10 Ctnnd1 Zc3h12a DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 96%75205 Dissolution of Fibrin Clot Plaur Hrg Plat Serpinb8 Plau S100a10 Serpinb6a Serpine2 Plg Serpine1 Anxa2 Serpinb2 Serpinf2 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948011 CASP5 inflammasome assembly STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 96%211736 Stimulation of the cell death response by PAK-2p34 Pak2 Casp3 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-HSA-1606322.3 ZBP1(DAI) mediated induction of type I IFNs Rela Ripk3 Dhx9 Ikbkb Ripk1 Nfkb2 Myd88 Tbk1 Nfkbib Zbp1 Ikbkg Irf3 Nlrp4e Ticam1 Dtx4 Tlr3 Nkiras1 Nkiras2 Nfkbia Nfkb1 Chuk BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME DATABASE ID RELEASE 96%9636467 Blockage of phagosome acidification Atp6v1h RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 96%9007101 Rab regulation of trafficking Dennd5b Dennd1b Dennd1c Rin3 Rin1 Rin2 Rab21 Chml Mon1b Dennd6a Mon1a Dennd6b Dennd2a Dennd2b Dennd2c Dennd2d Hps1 Rab12 Rab18 Rab11a Hps4 Trappc12 Gapvd1 Trappc11 Rabgef1 Trappc13 Ywhae Gga2 Rinl Gga1 Rab4a Ankrd27 Optn Gga3 Dennd3 Rabgap1 Tbc1d14 Tbc1d13 Tbc1d16 Trappc6b Tbc1d15 Rab11b Trappc9 Arf6 Rab33b Trappc6a Rab33a Trappc5 Tbc1d17 Trappc4 Rabep1 Tbc1d2 Trappc3 Rab35 Tbc1d7 Trappc2 Gabarapl2 Trappc1 Tbc1d10c Rab8b Rab1a Tbc1d10b Tbc1d10a Ulk1 Rab1b Trappc2l Sytl1 Tbc1d25 Gabarap Tbc1d20 Tbc1d24 Trappc10 Map1lc3b Sbf1 Akt3 Akt2 Akt1 Rab3ip Rab10 Rab13 Rab14 Rab8a Rab3a Chm Rab5a Rab9 Rab5c Rab5b Rab9b Ric1 Rab27a Rab6b Rab6a Rgp1 Tsc2 Tsc1 Rab7 Als2 Rab27b Sbf2 Als2cl Gdi1 Gdi2 Rab3il1 Dennd4c Dennd4a Dennd4b Rab39b Rab31 Rab32 Trappc8 Rab39 Rab38 Dennd5a Rab3gap1 Dennd1a DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 96%9845622 Defective VWF binding to collagen type I Vwf CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding Pfdn6 Cct6a Pfdn5 Pfdn4 Tuba1b Tuba1a Pfdn2 Pfdn1 Tuba1c Gba1 Tubal3 Rgs9 Rgs6 Rgs7 Stat3 Cct3 Cct2 Skic2 Tubb2b Vbp1 Kif13a Tubb2a Fkbp9 Fbxw10 Actb Fbxw4 Fbxw5 Fbxw7 Fbxw9 Ccne1 Xrn2 Ccne2 Sphk1 Tcp1 Tuba4a Cct6b Fbxw2 Gna11 Gna15 Gna14 Fbxo4 Gapdhs Fbxo6 Tuba8 Lonp2 Arfgef2 Gnaq Pdcl Tuba3b Cct8 Cct7 Cct5 Cct4 Dcaf7 Csnk2b Wrap53 Tubb6 Tubb3 Trp53 Tubb1 Rgs11 Fbxl3 Fbxl5 Ap3m1 Gng10 Nop56 Tubb4b Tubb4a Gng3 Gng2 Gng4 Gng7 Gng8 Hdac3 Gngt1 Gngt2 Csnk2a2 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME%R-HSA-5579027.5 Defective CYP27B1 causes VDDR1B Cyp2r1 BASIGIN INTERACTIONS%REACTOME%R-HSA-210991.3 Basigin interactions Slc16a8 Slc16a1 Ppia Spn Ppil2 Mag Itga6 Itga3 Slc7a11 Slc7a10 Mmp1a L1cam Slc3a2 Itgb1 Cav1 Slc7a6 Bsg Slc7a7 Atp1b1 Slc7a5 Atp1b3 Atp1b2 Slc7a8 Slc7a9 Slc16a3 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 96%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) Ubn1 Trp53 Hmga1 H1-1 H1-0 Rb1 Asf1a H1-5 H1-4 H1f2 Hmga2 H1f3 Ep400 Hira Cabin1 Lmnb1 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654706 FRS-mediated FGFR3 signaling Fgf16 Frs2 Fgf18 Fgf2 Fgf1 Nras Fgf4 Frs3 Sos1 Fgf9 Hras Fgf20 Ptpn11 Fgf23 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER Rpa2 Xrcc1 Lig3 Aqr Rpa3 Polk Pole Uvssa Znf830 Rbx1 Polr2c Ubc Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2h4 Gtf2h3 Usp7 Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Ercc8 Ddb1 Lig1 Isy1 Cul4a Cul4b Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Rfc1 Rfc2 Pold4 Pold3 Ercc6 Pole3 Pole2 Pole4 Tcea1 Xab2 Ppie Prpf19 Rpa1 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases Lrrc4b Slitrk6 Slitrk4 Slitrk1 Slitrk2 Ptprs Slitrk5 Ptprf Slitrk3 Ntrk3 Il1rapl1 Il1rapl2 Ppfia2 Ppfia4 Ppfibp2 Ppfia1 Ppfibp1 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Cenpo Cenpn Cenpm Mis12 Plk1 Nup133 Cenpl Zwilch Cenpk Cenpi Cenph Cenpf Cenpe Clasp1 Clasp2 Pafah1b1 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Kif2b Kif2c Dync1li2 Pmf1 Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Ppp2r1b Ppp2r1a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Xpo1 Nuf2 Nup85 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 96%426048 Arachidonate production from DAG Daglb Abhd6 Abhd12 Mgll Dagla COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding Tubb6 Tubb3 Tubb1 Pfdn6 Cct6a Pfdn5 Pfdn4 Tubb4b Tuba1b Tubb4a Tuba1a Pfdn2 Pfdn1 Tuba1c Tubal3 Cct3 Cct2 Tubb2b Vbp1 Tubb2a Actb Tcp1 Tuba4a Cct6b Tuba8 Tuba3b Cct8 Cct7 Cct5 Cct4 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670095.3 Inhibition of DNA recombination at telomere H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Tinf2 H2bc3 H2bc21 H2bc26 H2ab2 H3c8 H2bu2 H2ac12 H2ac11 Atrx Acd H2ac15 H2ax Terf2ip Polr2c Polr2d Polr2a Polr2b Terf2 Polr2g Hist1h2bp Terf1 Polr2h Daxx Hist2h2aa1 Polr2e Polr2f Polr2k H2aj Polr2i Polr2j Pot1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Rrp8 H2bc3 H2bc21 H2bc26 Suv39h1 H2ab2 H2bu2 H2ac12 H2ac11 H2ac15 Tbp H3c7 H2ax Hist1h2bp Taf1d Hist2h2aa1 Taf1a Taf1c Taf1b H2aj Sirt1 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones Aanat Tph2 Duox1 Duoxa1 Duoxa2 Cav1 Dio1 Txndc11 Dio2 Tph1 Dio3 Duox2 Tpo Ddc Iyd Pnmt Cga Th Slc5a5 Dbh Tshb SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Yes1 Jak2 Lck Nras Sos1 Stat5a Stat5b Hras Pik3ca Fyn Stat3 Stat1 Kit Pik3r1 Pik3r2 Lyn UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%438066 Unblocking of NMDA receptors, glutamate binding and activation Actn2 Nefl Gria2 Grin1 Dlg1 Grin2d Dlg3 Grin2c Dlg4 Gria4 Gria3 Camk2g Camk2d Gria1 Grin2b Camk2b Camk2a Grin2a Dlg2 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660514 Synthesis of PIPs at the Golgi membrane Pi4kb Pi4ka Pik3c3 Arf3 Pikfyve Pik3c2g Fig4 Vac14 Pi4k2a Pik3c2a Tpte Pik3r4 Inpp5e Ocrl Arf1 Sacm1l Pi4k2b DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema F2 F12 Klkb1 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) Tas2r40 Tas2r41 Casr Grm1 Grm5 Tas2r39 Tas2r119 Tas2r38 Grm3 Grm2 Grm4 Gabbr1 Grm7 Grm8 Gabbr2 Tas1r2 Tas1r1 Tas2r120 Tas1r3 Tas2r16 Tas2r131 Tas2r13 Tas2r135 Tas2r137 Gprc6a Tas2r136 Tas2r140 Tas2r4 Tas2r107 Tas2r7 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.4 Anti-inflammatory response favouring Leishmania parasite infection Prkaca Cd3g Itpr3 Itpr2 Itpr1 Adora2b Ggt1 Prkx Plcg2 Dpep1 Dpep2 Prkacb Il6 Ggt5 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Gnaz Fcgr1 Adcy9 Fcgr3 Fcgr4 Syk Furin Fgr Gnai2 Gnai1 Gnai3 Prkar1b Mapk14 Gnat3 Prkar2b Cysltr2 Cysltr1 Gng10 Plcg1 Fyn Gng3 Gng2 Prkar1a Gng4 Gng7 Gng8 Lyn Adam17 Yes1 Prkar2a Gngt1 Gngt2 Rhbdf2 Il10 Cd163 Plk2 Myh9 Ahcyl1 Gnb2 Gnb1 Hck Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 96%164939 Nef mediated downregulation of CD28 cell surface expression Ap2m1 Cd28 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling Prkaca Jak2 Il2 Csf2 Il3ra Jak3 Il2rb Ptpn6 Csf2rb2 Rapgef1 Csf2ra Sos1 Il5 Stat5a Blnk Crk Stat5b Il5ra Ptpn11 Gab2 Fyn Il2rg Inpp5d Tec Lyn Ywhaz Yes1 Il2ra Inppl1 Cbl Pik3cb Pik3cd Pik3ca Shc1 Jak1 Syk Crkl Vav1 Hck Pik3r1 Pik3r2 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 96%8981373 Intestinal hexose absorption Slc2a2 Slc5a1 Slc2a5 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 96%2871809 FCERI mediated Ca+2 mobilization Nfatc1 Nfatc3 Itpr3 Nfatc2 Vav2 Itpr2 Itpr1 Ppp3r1 Ppp3ca Plcg1 Ppp3cb Sos1 Grap2 Itk Plcg2 Ahcyl1 Txk Lcp2 Syk Vav1 Btk Tec Lyn Vav3 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 96%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) Slc6a19 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-HSA-8850843.6 Phosphate bond hydrolysis by NTPDase proteins Entpd6 Entpd3 Entpd7 Entpd8 Entpd1 Entpd5 Entpd2 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping Wnt5a Nox1 Rac1 Noxo1 Mapk8 Dvl1 Cyba Fzd7 Dvl2 Dvl3 Jun Noxa1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 96%8939256 RUNX1 regulates transcription of genes involved in WNT signaling Esr1 Rspo3 Foxp3 Cbfb Axin1 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation Trp53 Prmt5 Ttc5 Atm Kmt5a Mdm2 Ubc Mdm4 Ehmt2 Chek2 Ehmt1 L3mbtl1 Smyd2 Ep300 Jmy BINDING AND ENTRY OF HIV VIRION%REACTOME%R-HSA-173107.5 Binding and entry of HIV virion Ccr5 Ppia Cxcr4 Cd4 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO Arrb1 Cdon Grk2 Csnk1a1 Dhh Ihh Shh Evc2 Iqce Evc Gas8 Efcab7 Kif3a Ptch1 Smo Boc Arrb2 Gas1 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins Aqp9 Aqp7 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 96%9660821 ADORA2B mediated anti-inflammatory cytokines production Prkaca Gnat3 Prkar2b Adora2b Gng10 Prkx Gng3 Gng2 Prkar1a Gng4 Gng7 Gng8 Prkacb Il6 Prkar2a Gngt1 Gngt2 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Gnaz Adcy9 Gnb2 Gnb1 Gnb4 Gnai2 Gnb3 Gnai1 Gnb5 Gng11 Gnai3 Gng12 Prkar1b Gng13 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Dll1 Notch1 Dll4 Jag2 Jag1 Adam10 Adam17 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020558 Interleukin-2 signaling Shc1 Il2 Syk Lck Jak1 Il2ra Il2rg Jak3 Il2rb Ptk2b Stat5a Stat5b MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis Mlkl Ripk3 Casp8 Ripk1 RAC2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013404 RAC2 GTPase cycle Vapb Pak1 Arhgap32 Pak4 Vav2 Prex1 Arhgap35 Pak2 Trio Mcf2 Esyt1 Mpp7 Ankle2 Cyfip1 Rac2 Tmpo Arhgap39 Def6 Pld2 Dsg2 Pik3ca Ncf1 Ncf2 Ncf4 Brk1 Samm50 Swap70 Git1 Tfrc Arhgap17 Nckap1l Mtx1 Tiam1 Bcr Lamtor1 Baiap2l1 Arhgap26 Cdc42ep4 Dock3 Syde1 Abr Nckap1 Slitrk5 Nhs Git2 Wasf2 Dock10 Racgap1 Lman1 Taok3 Rab7 Cyba Abi2 Abi1 Arhgdia Armcx3 Cybb Garre1 Arhgap42 Erbin Emd Lemd3 Lbr Diaph3 Cdc42ep1 Depdc1b Vrk2 Vamp3 Epha2 Itgb1 Dock4 Cav1 Arhgap1 Pgrmc2 Vav1 Arhgap21 Vangl1 Mcam Ophn1 Pik3r1 Stbd1 Pik3r2 Vav3 Dock1 Iqgap1 Dock2 WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL Pip5k1b Csnk1e Dvl1 Dvl2 Csnk2a2 Dvl3 Csnk2b AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 96%211163 AKT-mediated inactivation of FOXO1A Akt3 Akt2 Akt1 Foxo1 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions Tlr4 Clec5a Dnajc8 Ddx3x Rbm22 Mmp9 Rbm17 Ddx46 Ddx42 Cd2bp2 Ddx23 Stat2 Ddx5 Sympk Cstf1 Papola Clp1 Nudt21 Cpsf1 Cstf2 Cpsf2 Cstf3 Cpsf3 Cstf2t Wdr33 Ripk1 Pdcd6ip Ybx1 Hspg2 Sdc4 Sdc3 Sdc2 F2 Sdc1 Camk2g Camk2d Camk2b Camk2a Hsp90aa1 Cpsf4 Cdc73 Rtf1 Gpc1 Gpc3 Gpc2 Leo1 Skic8 Gpc5 Gpc4 Gpc6 Rpl18 Ctr9 Paf1 Pabpn1 Hspa8 Daxx Agrn Fasn Rnps1 Pik3c3 Srsf1 Srsf9 Cdc40 Srsf7 Srsf6 Pik3r4 Srsf3 Srsf2 Srsf11 Srrm1 Nrbp1 Alyref Dhx38 U2af1l4 Elavl1 Eif4a3 Snrpb H2ac21 H2ac25 Snrpd2 Hist1h2af Snrpd1 Clu H2ac1 Snrpd3 C4a C1qa C1s2 Taok1 Mbl2 Cgas Sting1 Dhx9 Vtn Ikbke Exoc1 Hnrnpu Tjp1 H2bc18 Polr2c Polr2d Polr2a Polr2b Nfkbib Polr2g Polr2h Becn1 Polr2e Polr2f Polr2k Nfkbia Polr2i Polr2j Ubr4 Gtf2f2 Gtf2f1 H2ac20 Ube2i H2ac12 H2ac11 H2ac15 H3c7 Phf5a Crnkl1 Hist1h2bp Xab2 Aup1 Hnrnpa2b1 Prpf19 Puf60 Hnrnpul1 Gbf1 Bcas2 Gpkow Smndc1 Aqr Pcbp2 Pcbp1 H2bc9 Grpel1 H2bc7 Hnrnpr H2bc8 H2bc3 Sugp1 Hnrnpd Hnrnpf Hnrnpk Ccar1 Hnrnpl Hnrnpm Rictor Rbmx Hnrnph2 Hnrnph1 Nek2 Cwc22 Ifih1 Hsp90ab1 H2bu2 Cwc27 Cpsf7 Hnrnpc Cwc25 Cwc15 Trim25 Mavs Rbm5 Tal1 Ctnnb1 Txnl4a Vim Fip1l1 Snrnp200 U2surp Snrpb2 Snrpa1 Cog1 Ptbp1 Hist2h2aa1 Prr5 Rptor Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b2 Sf3b3 Mlst8 Sf3b4 Sf3b5 Sf3b6 H2bc14 Ctnnbl1 Srrt Mtor Snrnp40 Eftud2 Snrpn H2bc21 H2bc26 Cherp Fus Isy1 Cdc5l Plrg1 Hnrnpa3 Mapkap1 Ppil6 Ppil4 Ppil3 Hnrnpa1 Hnrnpa0 Ppil1 Prcc Rbm10 Elavl2 Dhx16 Dhx15 Retreg1 Srrm2 Ncbp2 Ncbp1 Pex19 Prpf6 Ly96 Ppie Apoa1 Prpf8 Wbp11 Pqbp1 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) Slc33a1 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription Tead3 Runx3 Tead2 Wwtr1 Tead1 Ccn2 Yap1 Tead4 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane Tlr4 App Ikbkb Jun Peli1 Ikbkg Map3k7 Traf2 Cd14 Btk Nfkb1 Socs1 Skp1 Fbxw11 Rela Btrc Casp8 Ubc Nfkbib Irak1 Nfkbia Cul1 Traf6 Ube2n Chuk Ube2v1 Trp53 Tab3 Sigirr Tab2 Tab1 S100a1 Irak3 Cd36 Tirap Rps6ka1 Tifa Alpk1 Nfkb2 Fos Fgb Fga Mapk9 Mapk7 Fgg Mapk8 S100a9 Elk1 S100a8 Tlr1 Tlr6 Tlr2 Map3k8 Mapk1 Mapk3 Rps6ka3 Mapkapk3 Rps6ka2 Mapkapk2 Map2k7 Mapk14 Map2k6 Ppp2cb Ppp2ca Map2k4 Map2k3 Mapk10 Map2k1 Mapk11 Ripk2 Myd88 Rps6ka5 Nkiras1 Atf2 Nkiras2 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Ppp2r1a Peli2 Peli3 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Usp18 Ppp2r5d Ly96 Mef2c DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling Nck1 Dcc Rac1 Src Ptk2 Wasl Trio Ablim1 Ntn1 Ablim2 Ablim3 Dock1 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Slc40a1 Cp EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%391903 Eicosanoid ligand-binding receptors Cysltr2 Ptgir Cysltr1 Ptgfr Ptger4 Ptger2 Ltb4r1 Gpr17 Ptger3 Ltb4r2 Tbxa2r Ptgdr Ptger1 Ptgdr2 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME%R-HSA-9664424.3 Cell recruitment (pro-inflammatory response) Pycard Sugt1 P2rx7 P2rx4 Entpd1 Nt5e Entpd5 C3ar1 Il18 Nfkb1 Txn Hmox1 Hsp90ab1 Nlrp3 Pstpip1 Rela Ctsg Casp1 Nfkb2 Gsdmd Il1a Il1b Mefv C3 Txnip STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction Tnni3 Ttn Tmod3 Dmd Tnnt3 Tnnt2 Tnnt1 Tnnc2 Tnnc1 Tmod1 Tmod4 Tmod2 Tcap Actn2 Neb Tnni2 Tnni1 Myl4 Des Myh3 Mybpc1 Mybpc2 Vim Myl1 Actn3 Mybpc3 Myl2 Myl3 Myh8 Myh6 Tpm3 Tpm2 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-HSA-73933.4 Resolution of Abasic Sites (AP sites) Rpa2 Polb Apex1 Xrcc1 Lig3 Rpa3 Parp2 Parg Pole Adprs Parp1 Lig1 Rfc5 Pold2 Neil2 Pold1 Rfc3 Nthl1 Pcna Ogg1 Rfc4 Neil1 Pnkp Mbd4 Rfc1 Smug1 Rfc2 Pold4 Mpg Pold3 Pole3 Pole2 Pole4 Fen1 Rpa1 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4615885 SUMOylation of DNA replication proteins Nup43 Sumo3 Ranbp2 Nup93 Pias3 Nup50 Pias4 Nup35 Nup54 Pom121 Nup205 Ube2i Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aurka Aaas Nup214 Nup210 Nup155 Nup153 Pcna Birc5 Nup85 Cdca8 Incenp Aurkb Nup37 Sec13 Top2b Top2a Nup160 Top1 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 96%437239 Recycling pathway of L1 Rps6ka4 Ezr Dpysl2 Rdx Msn Clta Ap2m1 Rps6ka5 Cltc Rps6ka1 Ap2a2 Ap2a1 Rps6ka6 L1cam Dnm2 Sh3gl2 Ap2b1 Ap2s1 Mapk1 Numb Shtn1 Rps6ka3 Rps6ka2 Dnm1 Kif4 Dnm3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events Taf4 Taf3 Taf2 Taf1 Cdc73 Rtf1 Leo1 Skic8 Aff4 Supt6 Iws1 Mllt3 Mllt1 Ctr9 Eaf1 Paf1 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Ell Nelfa Nelfb Nelfe Taf15 Ctdp1 Taf11 Taf13 Taf12 Ccnk Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Taf9 Ncbp2 Ncbp1 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Taf8 Eloa Taf7 Taf6 Eloc Taf5 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora Ppp1r3c Epm2a Gys1 Nhlrc1 Gyg1 Ubc NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.5 NEP NS2 Interacts with the Cellular Export Machinery Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Ran Xpo1 Nup85 Nup37 Sec13 Nup160 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription Hey2 Notch2 Hey1 Mamld1 Smad3 Notch1 Flt4 Kat2b Maml1 Maml2 Kat2a Hes5 Rbpj Crebbp Hes1 Notch4 Ep300 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 96%8849474 PTK6 Activates STAT3 Ptk6 Stat3 Socs3 Stap2 SIGNALING BY RNF43 MUTANTS%REACTOME%R-HSA-5340588.4 Signaling by RNF43 mutants Lrp6 Rnf43 Lrp5 Fzd5 Fzd4 Wnt3a Fzd6 Fzd8 INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME DATABASE ID RELEASE 96%5659898 Intestinal saccharidase deficiencies Sis Lct CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 96%110331 Cleavage of the damaged purine H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Tinf2 H2bc3 H2bc21 H2bc26 H2ab2 H3c8 Neil3 H2bu2 Ogg1 H2ac12 H2ac11 Acd Mpg H2ac15 H2ax Terf2ip Terf2 Hist1h2bp Terf1 Hist2h2aa1 H2aj Pot1 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 96%2243919 Crosslinking of collagen fibrils Lox Pcolce Loxl2 Loxl1 Loxl4 Loxl3 Pxdn Bmp1 Tll2 Tll1 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 96%9918432 Maturation of DENV proteins Dnajc10 Magt1 Kpna4 Kpna7 Prkg2 Kpna3 Ube2i Acot2 Dnajc3 Tmem258 Calr Kpna1 Rpn2 Rpn1 Sec11c Sec11a Canx Stt3a Stt3b Ostc Xpo1 Hyou1 Dpm1 Dpm2 Scap Ubc Dpm3 Nmt1 Spcs3 Spcs1 Spcs2 Tusc3 Hspa5 Dnajb11 Pdia3 Dad1 Kpnb1 Ipo7 Apoa1 P4ha1 P4hb Ddost P4ha2 P4ha3 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling Cd3g Cd3e Cd3d Psma4 Ikbkb Psma3 Psma6 Psma5 Psma2 Trat1 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Malt1 Ube2d1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Card11 Btrc Psma7 Psmc6 Psmc5 Psmc2 Pik3cb Psmc1 Psmc4 Psmc3 Ubc Bcl10 Pik3ca Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Pdpk1 Adrm1 Sem1 Traf6 Cul1 Ube2n Prkcq Chuk Cdc34 Ube2v1 Lck Tab2 H2-Eb1 Cd4 Ripk2 Inpp5d Pten Pik3r1 Pik3r2 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME DATABASE ID RELEASE 96%164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Ap1s3 Ap1s2 Ap2a2 Ap1b1 Ap1s1 Ap2a1 Ap1g1 Lck B2m H2-Q10 Cd4 Ap2b1 Cd28 Atp6v1h Ap2s1 Ap2m1 Cd8b1 Ap1m2 Ap1m1 Arf1 Pacs1 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription Rcor1 Sall4 Jun Gatad2a Gatad2b Kdm1a Mbd3 Ring1 Cbx8 Phc2 Cbx6 Phc1 Cbx4 Mta1 Cbx2 Mta3 Phc3 Mapk1 Mapk3 Bmi1 Atn1 Rptor Maf1 Eed Rnf2 Slc38a9 Trp53 Lamtor5 Lamtor4 Rraga Mlst8 Rragb Lamtor1 Rragc Pparg Lamtor2 Rragd Mtor Hdac2 Hdac1 Hdac5 Hdac7 Rbbp4 Rbbp7 Atf2 Egr1 Chd3 Chd4 Mecom Nr2e1 Hdac3 Ezh2 Rest Snai2 Suz12 Mta2 Snai1 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic Arfgap1 Kdelr2 Stx5 Capzb Ykt6 Capza1 Capza2 Actr1a Copz2 Copz1 Dctn2 Arf5 Dctn3 Plin3 Rab18 Galnt2 Cenpe Sec22b Rab33b Rab1a Rab1b Tmed9 Gosr2 Tmed3 Copg1 Copg2 Kif3a Kif3b Kif3c Copb2 Agpat3 Pla2g6 Kif4 Galnt1 Copb1 Man2a1 Arf4 Pafah1b3 Pafah1b2 Actr10 Dctn5 Dctn6 Dctn1 Dctn4 Kif26a Capza3 Bicd2 Kif11 Bicd1 Kif15 Kif22 Kif23 Kif20a Kdelr3 Klc1 Klc4 Klc3 Klc2 Cux1 Cyth2 Cyth3 Golga5 Cyth4 Cyth1 Golim4 Snap29 Kifap3 Gbf1 Kif18b Vps45 Use1 Kif26b Trip11 Kifc2 Kif12 Nsf Kif21a Kif1c Kif21b Kif13b Kif1a Kif1b Bnip1 Kif6 Kif9 Stx18 Kif27 Rint1 Kif16b Kif20b Kif19a Surf4 Arf1 Arfgap2 Arcn1 Rab30 Rab36 Rab9 M6pr Golga4 Rab43 Tmf1 Golga1 Bet1l Vps51 Vps52 Vps53 Vps54 Arl1 Gcc2 Gcc1 Rab9b Cog1 Usp6nl Kdelr1 Cog2 Stx6 Cog3 Pafah1b1 Cog4 Kif5b Cog6 Cog7 Zw10 Cog8 Igf2r Napa Napb Ric1 Scoc Naa35 Vti1a Naa38 Napg Rab6b Vamp4 Kif2a Rab6a Rgp1 Kif2b Naa30 Kif2c Stx16 Dync1li2 Arfip2 Rhobtb3 Rabepk Arfrp1 Dync1li1 Alppl2 Dynll1 Dynll2 Racgap1 Copa Pla2g4a Arfgap3 Kif18a Dync1h1 Arf3 Man1a Man1a2 Man1c1 Cope Vamp3 Gosr1 Dync1i2 Dync1i1 Rab39 Rab3gap1 ASPIRIN ADME%REACTOME%R-HSA-9749641.4 Aspirin ADME Ugt2a3 Ugt2b1 Bche Slc16a1 Ugt1a6 Ugt1a9 Ugt3a2 Ugt1a5 Ugt1a1 Ugt2b38 Ugt2b36 Ugt2b34 Cyp2d22 Abcc2 Cyp3a16 Cyp2c65 Cyp2e1 Glyatl3 Acsm2 Cyp2c50 Acsm4 Acsm5 Glyat Abcc3 Bsg Ces1d Ces2h Alb Ugt1a2 Ugt2a1 Ugt2a2 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%156711 Polo-like kinase mediated events Ccnb2 Mybl2 Plk1 Foxm1 Lin54 Rbbp4 Lin9 Wee1 Cenpf Lin37 Cdc25c Ep300 Pkmyt1 Cdc25a HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE Pla2g4c Gpcpd1 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702636.2 tandutinib-resistant FLT3 mutants Flt3 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-HSA-3134975.4 Regulation of innate immune responses to cytosolic DNA Trim32 Tbk1 Zbp1 Irf3 Trim21 Nlrp4e Dtx4 Sting1 Trim56 Ddx41 Trex1 Ubc DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 96%5578996 Defective CYP27A1 causes CTX Cyp27a1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function Rdh12 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159227 Transport of the SLBP independent Mature mRNA Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Eif4e Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Alyref Nxf1 Nup85 Ncbp2 Ncbp1 Nup37 Sec13 Nup160 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis Prps1l1 Prps1 Prps2 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-HSA-210745.3 Regulation of gene expression in beta cells Nkx2-2 Nkx6-1 Mafa Pdx1 Pax6 Neurod1 Foxa2 Slc2a2 Hnf4g Gck Foxa3 Rfx6 Hnf1a Foxo1 Akt3 Iapp Akt2 Akt1 Ins2 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Dag1 Pomgnt1 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism Ppp2cb Prkaca Ppp2ca Ppp2r5d Pfkfb4 Pfkfb3 Pfkfb1 Prkacb Ppp2r1b Ppp2r1a EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 96%1474244 Extracellular matrix organization Col4a1 Pcolce Col24a1 P3h2 Colgalt1 Col5a1 Col25a1 P3h1 Col4a2 P3h3 Col9a2 Itgb5 Pcolce2 Col9a3 Crtap Colgalt2 Mmp9 Col6a6 Col8a1 Serpinh1 Col6a3 Plod3 Col4a5 Plod1 Col9a1 Cast Plod2 Col8a2 Col4a6 Col20a1 Tgfb2 Adamts1 Capn1 Mmp14 Adamts5 Capn2 Mmp16 Adamts4 Timp1 Adamts3 Timp2 Adamts2 Adamts8 Capns1 Capns2 Ctsd Bmp10 Itga8 Adamts14 Tgfb3 Ltbp3 Ltbp2 Elane Ltbp4 Adamts16 Ltbp1 Ctsg Adamts18 Itgb8 Itgb6 Ptprs Itgav Nrxn1 Dag1 Bmp1 Tll2 Tll1 P4hb A2m Itga9 Itga10 Ncam1 Itga2b Hspg2 Klkb1 Sdc4 Sdc3 Sdc2 Mmp1a Sdc1 Bmp4 Mmp13 Tgfb1 Cask Ncan Bgn Dcn Bcan Vcan Spp1 Fmod Mmp3 Cd44 Musk Tnn Tnr Tnxb Matn1 Matn4 Lrp4 Aspn Dspp Hapln1 Sh3pxd2a Serpine1 Adam12 Adam15 Agrn Tnc Itgax Comp Itgam Itgae Itgad Itgb7 Itgb2 Icam5 Icam4 Ctrb1 Cd47 Fgf2 Jam3 Jam2 Itga11 Ibsp Fbn1 Pdgfa Itga7 Itga6 Icam1 Nid2 Nid1 Itgb4 Itga3 Pdgfb Adam10 Itga1 Itga2 Sparc Adam17 Ctsb Ctss Col1a2 Col1a1 Mmp2 Dmp1 Thbs1 Vcam1 Ctsk Lum Ctsl Pecam1 Sntg2 Dtna Fn1 Plg Dtnb Lama5 Matn3 Vtn Sgcz Snta1 Lamb2 Sspn Lama1 Dmd Lamc3 Lamb3 Sntb2 Lama2 Sntb1 Lama3 Sgce Lama4 Sgcd Sgcb Lamc1 Lamb1 Sgca Lamc2 Sgcg Trappc4 Casp3 Bmp7 Lox Loxl2 Loxl1 Loxl4 Loxl3 Optc Klk7 Gdf5 Tmprss6 Ddr2 Mmp24 Mmp25 Eln Fbln1 Fbln2 Mmp20 Fbln5 Mmp11 Mmp12 Mmp15 Mmp17 Mmp19 Bmp2 Mmp10 Ddr1 Prkca Phykpl Pxdn Htra1 Efemp2 Efemp1 Fbn2 Capn9 Plec Scube3 Capn8 Scube1 Capn5 Capn7 Capn6 Capn3 Tpsb2 Adam9 Adam8 Mmp8 Cd151 Capn15 Mfap4 Mfap5 Mfap2 Mfap3 Spock3 Capn10 Utrn Capn11 Capn13 Ntn4 Drp2 Bsg P4ha1 P4ha2 P4ha3 Fgb Fga Fgg Itgb3 Cma1 Actn1 Ttr Cdh1 Kdr Prss2 Furin Itga5 F11r Itga4 Icam2 Itgal Col15a1 Col16a1 Col17a1 Col18a1 Col11a1 Col12a1 Col11a2 Col13a1 Col14a1 Psen1 Col19a1 Col10a1 Ncstn Col2a1 Itgb1 Col26a1 Adam19 Col3a1 Col27a1 Col28a1 Col22a1 Col6a1 Col5a2 Col4a3 Col23a1 Ppib Col7a1 Col6a2 Col5a3 Col4a4 Mmp7 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%109703 PKB-mediated events Pde3b Akt2 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) Slc5a7 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis Ppp1r3c Gbe1 Pgm1 Ugp2 Epm2a Gys1 Nhlrc1 Gys2 Gyg1 Ubc SENSORY PERCEPTION OF SALTY TASTE%REACTOME DATABASE ID RELEASE 96%9730628 Sensory perception of salty taste Calhm1 Scnn1a Scnn1b Scnn1g NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions Cacnb1 Col4a1 Cacnb2 Cacna1d Prnp Pspn Col4a2 Col9a2 Col9a3 Nrtn Col6a6 Col6a3 Col4a5 Col9a1 St8sia2 Ncam1 Ncan Cacna1c Cntn2 Gdnf Gfra1 Artn Gfra2 Cacna1g Gfra4 Cacna1h Agrn St8sia4 Col6a1 Cacna1s Cacna1i Col4a3 Cacnb3 Col6a2 Cacnb4 Col4a4 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall Selp Epcam Ppia Pecam1 Spn Ppil2 Mag Fn1 Tnfrsf10b Slc7a11 Slc7a10 Grb7 L1cam Slc3a2 Itgav Slc7a6 Slc7a7 Slc7a5 Slc7a8 Slc7a9 Cd74 Inpp5d Sdc4 Sdc3 Sdc2 Lyn Yes1 F2 Cxadr Selplg Jaml Cd84 Sele Glg1 Sell Mmp1a Esam Vpreb1b Sdc1 Sirpa Vpreb3 Cd99l2 Olr1 Gypc Fcamr Cav1 Cd244 Cd2 Bsg Cd48 Atp1b1 Trem1 Atp1b3 Atp1b2 Pik3r1 Pik3r2 Dok2 Slc16a3 Slc16a8 Slc16a1 Jchain Tgfb1 Itgb3 Gpc1 Pick1 Cd44 Proc Tspan7 Pik3cb Mertk Pf4 Pik3ca Shc1 Pros1 Gas6 Itgax Itgam Gp6 Itgb2 Fcer1g Lck Cd47 Jam3 Nras Jam2 Plcg1 Angpt1 Ptpn6 Itga5 Sos1 Tek Procr F11r Hras Ptpn11 Fyn Cd177 Itga4 Thbd Itga6 Itga3 Grb14 Angpt2 Angpt4 Itgal Itgb1 Mif Apob TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-HSA-174430.6 Telomere C-strand synthesis initiation Prim2 Prim1 Acd Pola2 Pola1 Terf2ip Tinf2 Terf2 Terf1 Ctc1 Stn1 Ten1 Pot1 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702590 gilteritinib-resistant FLT3 mutants Flt3 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 96%1483213 Synthesis of PE Pisd Pcyt2 Lpin3 Selenoi Lpin2 Cept1 Lpin1 Chka Etnppl Chkb Etnk1 Phospho1 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%416993 Trafficking of GluR2-containing AMPA receptors Ap2a1 Gria2 Prkcb Grip2 Nsf Prkca Gria4 Tspan7 Gria3 Prkcg Gria1 Grip1 Pick1 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-HSA-174437.5 Removal of the Flap Intermediate from the C-strand Pcna Rpa2 Acd Pold4 Pold3 Rpa3 Dna2 Terf2ip Tinf2 Terf2 Terf1 Wrn Fen1 Pot1 Pold2 Pold1 Rpa1 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins Nup43 Vhl Ranbp2 Nup93 Nup50 Pias4 Nup35 Trim27 Nup54 Pom121 Nup205 Ube2i Nup133 Nup188 Tpr Nup107 Rae1 Pias1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Nup85 Mdm2 Pml Nup37 Sec13 Nup160 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654720 PI-3K cascade:FGFR4 Fgf16 Frs2 Fgf15 Fgf18 Fgf2 Fgf1 Gab1 Fgf4 Fgf6 Fgf9 Fgf20 Ptpn11 Pik3ca Fgf23 Fgfr4 Pik3r1 Klb LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8853383 Lysosomal oligosaccharide catabolism Man2c1 Manba Man2b2 Man2b1 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport Slc22a18 Slc22a15 Slc22a5 Slc47a1 Slc14a2 Slc25a26 Slc22a4 Slc22a16 Slc14a1 Slc22a2 Slc22a3 Slc22a1 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1793185 Chondroitin sulfate dermatan sulfate metabolism Chst3 Chst11 Chst12 Chsy1 Chst7 Chsy3 Chst13 Chst14 Chst15 Hexa Hexb Idua Ncan Bgn Cspg5 Cspg4 Ust Dcn Bcan Vcan Glb1 Hyal4 Hyal3 Ids Dse Hyal1 Glb1l3 Glb1l2 Arsb Gusb Dsel Csgalnact1 Chpf Csgalnact2 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 96%167826 The fatty acid cycling model Slc25a27 Ucp2 Ucp3 Ucp1 Slc25a14 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation Fgfr1 Snai1 Eomes T AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 96%209563 Axonal growth stimulation Ngf Ngfr Arhgdia Rhoa CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.10 Cell-Cell communication Sp1 Arhgap32 Tyk2 Banp Birc2 Angptl4 Ang Xiap Kdm1a Zfp217 Ptk2 Ank3 Pomt1 Pomt2 Sptan1 Vasp Wasl Tgif2 Klf9 Strap Nck2 Foxj2 Foxp2 Nck1 Sptbn1 Twist2 Twist1 Ptk2b Cdh4 Cask Cdh15 Nectin1 Nectin2 Nectin3 Nectin4 Pard6b Il6 Cldn23 Cldn6 Cldn3 Cldn4 Cldn9 Canx Cldn20 Cldn22 Cldn7 Cldn8 Pard6g Cldn12 Rb1 Cldn15 Arid1a Cldn14 Cldn11 Cldn10 Cldn1 Dnm2 Cldn17 Kmt5a Mdm2 Zmym2 Fyb1 Cldn16 Cldn19 Cldn18 Cadm3 Cadm2 Cadm1 Cldn2 Mtbp Rack1 Foxq1 Il6st Wt1 Zc3h12a Farp2 Cdh9 Cdh7 Cdh6 Cdh5 Cdh3 Tle1 Sdk1 Cd47 Pcsk7 Tiam1 Sdk2 Cdh19 Cdh17 Pkm Cdh13 Foxa2 Cdh12 Cdh10 Zbtb33 Hdac2 Mphosph8 Mcrip1 Prkci Itga6 Itgb4 Smarca4 Il6ra Zeb2 Actn4 Ctsb Ctss Hace1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Lamb3 Psmd14 Lama3 Psmd13 Nfkb1 Psmb5 Lamc2 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rela Psma7 Psmc6 Pip5k1c Actn3 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Ganab Cdh2 Mogs Pxn Rnf19b H2ac20 Zeb1 Tcf3 Hdac1 Plec Myc Prkcsh Traf7 Rpn2 Rpn1 Cd151 Mov10 Actn2 H2ac12 H2ac11 Ago4 Tyrobp Ago3 Ago2 Ago1 H2ac15 Sox10 H3c7 Ezh2 H2ax Snai2 Csnk2a2 Sirpa Suz12 Rac1 Hist1h2bp Jak1 Cldn5 H2aj Pik3r1 Pik3r2 Cd2ap Sirpb1b Iqgap1 Rsu1 Jup Tesk1 Jak2 Kirrel1 Kirrel2 Kirrel3 Parvb Parva Vav2 Skap2 Lims2 Nphs1 H2bc9 Magi2 H2bc7 Flnc H2bc8 Fblim1 Ilk H2bc3 Vcl Stat3 Tmem258 Arhgef6 Arhgef4 H2ab2 Mycn Sec11c Sec11a H2bu2 Actn1 Stt3a Src Ctnnb1 Eps15 Cbll1 Ostc Tcf12 Ctnnd1 Pik3cb Cdh1 Crb3 Pik3ca Patj Pals1 Mapk1 Mapk3 Hist2h2aa1 Furin Ctbp1 Ctbp2 Pcsk6 Dad1 Ddost Csnk2b Eed Fermt2 H2bc14 Pard6a Ptpn6 Pard3 F11r Tfap2a Ptpn11 Fyn H2bc21 Tnrc6c H2bc26 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Col17a1 Spcs3 Spcs1 Hoxc8 Spcs2 Itgb1 Heyl Cdh8 Adam19 Adam33 Cdh24 Elmo1 Ctnna1 Snai1 Klf4 Prdm8 Ilf3 Flna Foxf1 Bhlhe22 Cdh11 Sirt1 Dock1 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 96%180786 Extension of Telomeres Nhp2 Rpa2 Rtel1 Gar1 Rpa3 Tinf2 Nop10 Shq1 Dscc1 Ruvbl2 Ppp6r3 Pif1 Ruvbl1 Chtf18 Ctc1 Chtf8 Stn1 Ten1 Ppp6c Acd Terf2ip Cdk2 Ccna1 Ccna2 Terf2 Terf1 Fen1 Pot1 Wrap53 Ankrd28 Tert Lig1 Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Prim2 Rfc1 Prim1 Rfc2 Pold4 Pola2 Pold3 Pola1 Dna2 Blm Wrn Dkc1 Rpa1 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 96%948021 Transport to the Golgi and subsequent modification Arfgap1 Kdelr2 Stx5 Capzb Ykt6 Capza1 Capza2 Actr1a Mia3 Copz2 Copz1 Dctn2 Arf5 Golga2 Dctn3 Tgfa Ctsc Scfd1 Ppp6r1 Ppp6r3 Lman2 Sec22c Sec22b Sec22a Tfg Preb Trappc6b Ppp6c Trappc9 Trappc6a Trappc5 Trappc4 Sec31b Trappc3 Chst10 Sec31a Trappc2 Tmem115 Trappc1 Spta1 F5 F8 Rab1a Stx17 Rab1b Sptb Trappc2l Tmed9 Gosr2 Lman1l Tbc1d20 Cd59b Tmed3 Uso1 Copg1 Sec23ip Copg2 Trappc10 Sec16b Ank3 Sec16a Mcfd2 Ank1 Lman2l Serpina1d Copb2 Cnih1 Gorasp1 Cnih3 Golgb1 Cnih2 Sptan1 Folr1 Copb1 Ankrd28 Bet1 Mgat5 Man2a1 Mgat2 Mgat1 Arf4 Fut8 St3gal4 Mgat4c Mgat4a Mgat4b Sptbn1 Sptbn2 Actr10 Dctn5 St6gal1 Dctn6 Dctn1 Dctn4 Capza3 Manea Sptbn4 B4galt4 B4galt5 B4galt6 Kdelr3 B4galt1 B4galt2 B4galt3 Csnk1d St8sia6 Cga Gbf1 Nsf St8sia2 St8sia3 Gria1 Fuca1 Chst8 Arf1 Arfgap2 Arcn1 Lhb Ctsz Bet1l Cog1 Kdelr1 Cog2 Cog3 Cog4 Cog6 Cog7 Cog8 Napa Mgat3 Napb Napg Dync1li2 Dync1li1 Areg Dynll1 Dynll2 Lman1 Copa Arfgap3 Dync1h1 Arf3 Man1a Sar1b Man1a2 Man1c1 Sec23a Cope Gosr1 Dync1i2 Dync1i1 Sec24d Sec24c Ins2 Col7a1 Sec24b Sec13 Sec24a REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME%R-HSA-9825892.3 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Hint1 Sin3a Ctnnb1 Tcf7 Lef1 Ccnd1 Hdac1 Tbx2 Cdk2 Met Plk1 Cdkn2a Cdkn1a Tcf7l1 Tcf7l2 Cdc25b IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-HSA-198933.9 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cd22 Cd3g Cd3e Cd3d Cd300lb Cd300lg Cd300lf Cd226 Npdc1 Cd40lg Mill2 Hcst Klrk1 Klrg1 Siglec1 Klrc1 Clec4g Nectin2 Lair1 Ncr1 Pianp Klrb1 Lilra5 Cd300e Cd1d2 Cd96 Treml2 Sh2d1a B2m Treml4 Treml1 H2-Q10 Cd300c2 Klrd1 Siglec12 Cd200 Cd160 Cdh1 Crtam Oscar Cd200r1 Fcgr2b Fcgr1 Cd300a Slamf6 Sh2d1b1 Cd8a Fcgr4 Slamf7 Pilra Pilrb Siglecg Itgb7 Itgb2 Icam5 Icam4 H2-M5 H2-M3 Itga4 Icam2 Icam1 Colec12 H2-Q1 Tyrobp Cxadr Jaml Itgal Trem2 Sell Itgb1 Cd81 C3 Trem1 Cd8b1 Cd19 Vcam1 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling Fkbp1a Slc38a9 Lamtor5 Akt1s1 Lamtor4 Rraga Mlst8 Rragb Eef2k Lamtor1 Rragc Lamtor2 Rragd Mtor Eif4b Eif4e Rptor Eif4ebp1 Eif4g1 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.3 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes Med27 Med12 Med13 Med14 Med10 H2bc9 Havcr2 H2bc7 H2bc8 H2bc3 Med16 Angptl4 Med17 Ncor2 Plin1 Mgll Cdk5 H2ab2 Kdm6a Fabp4 Pex11a H2bu2 Ncoa3 Lpin1 Elovl5 Cidec Nr5a2 Dgat2 Gps2 Rb1 Ppargc1b Lipe Plin4 Acsl1 Lpl Pnpla2 Thrsp Kmt2c Phlda1 Hist2h2aa1 Dpy30 Agpat2 Wdr5 Med30 Med31 Adipoq Kmt2d H2bc14 H2ac20 Rxra Cd36 H2bc21 H2bc26 Pagr1a Rbbp5 Ncor1 Abl1 Paxip1 Ep300 Cdk8 Tbl1x Ajuba Cebpa H2ac12 H2ac11 Plin2 Hdac3 Scd1 H2ac15 Ncoa2 H3c7 Ncoa1 H2ax Tbl1xr1 Ncoa6 Ash2l Hist1h2bp Med1 H2aj Ppargc1a Pdk4 Ccnc Crebbp Med23 Med4 Med24 Med6 Med20 Sirt1 Gpam MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling Prkaca Pak1 Pak3 Pak2 Psma4 Psma3 Jun Psma6 Foxo1 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Cdk1 Foxo3 Psmb5 Prkacb Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Ncoa3 Psma7 Psmc6 Psmc5 Psmc2 Ccnd3 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Igf2bp1 Mapkapk5 Septin7 Mapk6 Mapk4 Cdc14b Cdc42ep2 Cdc42ep5 Etv4 Cdc42ep3 Myc Dnajb1 Tnrc6c Rag2 Rag1 Tnrc6a Hspb1 Tnrc6b Cdc14a Mov10 Ago4 Ago3 Ago2 Ago1 Xpo1 Rac1 Kalrn DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME%R-HSA-5619052.4 Defective SLC9A9 causes autism 16 (AUTS16) Slc9a9 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 96%5358346 Hedgehog ligand biogenesis Sel1l Dhh Psma4 Psma3 Syvn1 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Gpc5 Psmd13 Psmb5 Psmb4 Derl2 Psmb7 Adam17 Psmb6 Psmb1 Psmb3 Psmb2 Notum Vcp Psma7 Psmc6 Psmc5 Psmc2 Ihh Psmc1 Psmc4 Psmc3 Shh Ubc Psmd7 Psmd6 Psmd8 Erlec1 Psmd3 Disp2 Psmd2 Psmd1 Hhat Os9 Adrm1 Sem1 P4hb RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 96%5625970 RHO GTPases activate KTN1 Rac1 Klc1 Klc4 Klc3 Klc2 Kif5b Rhog Ktn1 Rhoa CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 96%5637810 Constitutive Signaling by EGFRvIII Cdc37 Nras Gab1 Plcg1 Cbl Sos1 Hras Egfr Pik3ca Egf Shc1 Hsp90aa1 Pik3r1 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias Slc26a2 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) Slc3a1 Slc7a9 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 96%2980766 Nuclear Envelope Breakdown Nup43 Ranbp2 Prkca Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Lemd2 Plk1 Nup133 Nup188 Tpr Nup107 Rae1 Vrk1 Ndc1 Nup42 Nup62 Nup88 Aaas Cdk1 Nup214 Banf1 Nup210 Lmnb1 Nup155 Nup153 Ctdnep1 Cnep1r1 Lpin3 Lpin2 Lpin1 Emd Lemd3 Prkcb Nek9 Ccnb2 Nek6 Nup85 Nek7 Nup37 Sec13 Nup160 DEFECTIVE LFNG CAUSES SCDO3%REACTOME%R-HSA-5083630.4 Defective LFNG causes SCDO3 Notch2 Notch3 Notch1 Lfng Notch4 GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones Inha Lhb Inhba Inhbb Cga Fshb Inhbc Tshb Inhbe PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer Foxo4 Foxo1 Tgfa Foxo3 Nr4a1 Flt3l Esr2 Nrg2 Chuk Nrg4 Nrg3 Gsk3a Esr1 Akt3 Akt2 Akt1 Strn Kit Casp9 Bad Cd28 Erbb2 Rac1 Vav1 Pik3r5 Pik3r6 Pik3r1 Pik3r2 Rac2 Trat1 Pdgfrb Ereg Pik3ap1 Hbegf Ntrk3 Btc Epgn Rictor Cd86 Cd80 Src Nrg1 Pik3cg Pik3cb Pik3cd Mdm2 Hgf Egfr Met Pik3ca Cdkn1a Cdkn1b Prr5 Flt3 Rps6kb2 Pdpk1 Klb Frs2 Fgf16 Fgf15 Irs1 Fgf18 Gsk3b Irs2 Akt1s1 Lck Fgf2 Mlst8 Fgf1 Bdnf Fgf4 Gab1 Fgf10 Fgf3 Fgf6 Ntf4 Fgf7 Ntrk2 Fgf9 Tsc2 Mtor Fgf20 Ntf3 Gab2 Ptpn11 Fgf23 Fyn Egf Fgfr4 Fgf22 Areg Mapkap1 Rhog Pdgfb Pten Pdgfra Cd19 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 96%1442490 Collagen degradation Mmp20 Mmp11 Mmp12 Col25a1 Mmp15 Col9a2 Ctsk Mmp13 Mmp19 Col9a3 Mmp9 Mmp10 Phykpl Col9a1 Mmp14 Adam9 Mmp8 Ctsd Mmp3 Adam10 Adam17 Elane Col15a1 Col16a1 Col17a1 Col18a1 Mmp1a Col12a1 Col13a1 Ctsb Col14a1 Col19a1 Col26a1 Furin Mmp2 Tmprss6 Col23a1 Mmp7 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%R-HSA-201722.7 Formation of the beta-catenin:TCF transactivating complex H2bc9 H2bc7 H2bc8 H2bc3 Cdc73 Leo1 Tle3 Ruvbl1 H2ab2 H3c8 H2bu2 Runx3 Ctnnb1 Tcf7 Trrap Pygo2 Pygo1 Hist2h2aa1 Bcl9l Bcl9 Dpy30 Wdr5 Men1 Tle4 Tle2 Tle1 Lef1 Kmt2b H2bc14 H2ac20 Tert Hdac1 Myc H2bc21 H2bc26 Rbbp5 Kat5 Smarca4 Tcf7l1 Ep300 Tcf7l2 H2ac12 H2ac11 H2ac15 H3c7 H2ax Axin2 Ash2l Hist1h2bp H2aj Crebbp SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-HSA-9006936.9 Signaling by TGFB family members Sp1 Ppp1cc Fkbp1a Itgb5 Rnf111 Gipc1 Hells Tgfb2 Inha Tgfbr3 Mmp14 Mmp16 Timp1 Fstl3 Timp2 Acvr2a Ppp1ca Klf16 Inhba Smurf2 Ppp1cb Smurf1 Grem2 Ube2m Bmp10 Acvrl1 Itga8 Amhr2 Amh Pmepa1 Tgfb3 Zfyve16 Ltbp3 Nog Gdf2 Ltbp2 Bmpr1a Ltbp4 Bmpr1b Ltbp1 Uchl5 Bmpr2 Smad9 Itgb8 Smad5 Itgb6 Fstl1 Usp15 Bambi Mtmr4 Ube2d3 Stub1 Ubc Itgav Nedd4l Smad1 Smad2 Ybx1 Bmp2 Smad3 Tgif1 Smad4 Tgif2 Tcf3 Smad6 Rxra Smad7 Hdac1 Strap Myc Rara Rbl1 Trim33 Mov10 Ago4 Ago3 Ago2 Ago1 Arrb2 Arrb1 Acvr1c Acvr1b Tgfb1 Acvr2b Cer1 Myog Itgb3 Myod1 Usp9x Ncor2 Cdkn2b Myf6 Junb Parp1 Tcf4 Myf5 Mycn Ube2d1 Ski Fst Drap1 Foxh1 Tfdp2 Tfdp1 Cbl Tcf12 Wwtr1 Serpine1 Mapk1 Mapk3 Furin Tgfbr1 Tgfbr2 Ppm1a Men1 Fgf2 Pard6a Pard3 Inhbb Cgn F11r Rhoa Nedd8 Prkcz Arhgef18 Tnrc6c Ncor1 Tnrc6a Tnrc6b Cdk8 Ep300 Ccnk Xpo1 E2f4 E2f5 Skil Psen1 Psen2 Ncstn Itgb1 Aph1b Col1a2 Cdk9 Ccnt2 Atp1b4 Ccnc Ccnt1 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR Pxn Nras Gab1 Plcg1 Ptpn12 Sos1 Hras Ptpn11 Egf Csk Tgfa Ereg Hbegf Areg Arhgef7 Btc Epgn Aamp Epn1 Adam10 Spry2 Adam17 Stam2 Sh3gl3 Eps15l1 Src Sh3kbp1 Stam Eps15 Cbl Hgs Sh3gl1 Sh3gl2 Ubc Egfr Pik3ca Shc1 Fam83b Adam12 Lrig1 Ptprk Pag1 Pik3r1 Fam83a Spry1 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 96%1295596 Spry regulation of FGF signaling Ppp2cb Ppp2ca Mapk1 Braf Mapk3 Cbl Spry2 Ppp2r1a Ubc Ptpn11 Mknk1 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication Ppp2cb Ppp2ca Prim2 Orc5 Prim1 Orc4 Pola2 Orc6 Pola1 Orc1 Tfdp2 Mcm8 Tfdp1 Orc3 Rb1 Orc2 E2f1 Cdk1 Ppp2r1b Ppp2r1a RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME Adk Nme2 Pnp Nme1 Nt5c2 Ada Slc29a3 Itpa Slc28a3 Slc28a2 Slc29a1 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs Cyp1a2 Cyp2d22 Cyp3a16 Cyp2c65 Cyp2e1 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME%R-HSA-9958825.1 Activation of STAT3 by cadherin engagement Jak2 Jup Vav2 Tyk2 Psma4 Psma3 Psma6 Psma5 Birc2 Vcl Psma2 Psma1 Stat3 Psmd12 Psmd11 Psmd14 Psmd13 Xiap Arhgef4 Nfkb1 Psmb5 Psmb4 Psmb7 Il6 Psmb6 Psmb1 Psmb3 Psmb2 Src Rela Ctnnb1 Cbll1 Psma7 Psmc6 Psmc5 Psmc2 Ctnnd1 Cdh1 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Il6st Adrm1 Sem1 Farp2 Tiam1 Rnf19b Traf7 Il6ra Ctsb Ctss Rac1 Jak1 Elmo1 Ctnna1 Hace1 Cdh11 Dock1 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 96%5663213 RHO GTPases Activate WASPs and WAVEs Baiap2 Nckap1l Wasl Nckap1 Cyfip1 Nck1 Wipf3 Arpc1b Actr2 Arpc1a Wasf2 Actr3 Wasf1 Wipf2 Wipf1 Abl1 Btk Actg1 Abi2 Actb Abi1 Arpc3 Arpc2 Cyfip2 Arpc5 Arpc4 Rac1 Mapk1 Ptk2 Mapk3 Brk1 Nckipsd Was Wasf3 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine Glyatl3 Acsm2 Acsm4 Acsm5 Glyat CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943962 CHD6, CHD7, CHD8, CHD9 subfamily Chd7 Chd6 Nqo1 H2bc14 Igf2 H2bc9 H2bc7 H2ac20 H2bc8 H2bc3 H2bc21 H2bc26 Ctcf H2ab2 Ep300 H2bu2 H2ac12 H2ac11 Ctnnb1 H2ac15 H3c7 H2ax Axin2 Dkk2 Mafk Hist1h2bp Hist2h2aa1 H2aj Nfe2l2 Crebbp Wdr5 Chd9 Nkd2 Fam124b Chd8 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Rbbp8 Brca2 Brca1 Rad51ap1 Brip1 Xrcc2 Dna2 Rad51c Rad51d Atm Blm Rad51b Bard1 Top3a Kat5 Exo1 Wrn Mre11a Nbn Sem1 Palb2 Rad51 Rad50 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion Cd36 Plcb3 Gnaq Plcb2 Acsl3 Plcb1 Gna11 Ffar1 Gna15 Gna14 Acsl4 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 96%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling Ube2v1 Myd88 Tlr9 Tlr7 Irak1 Irak4 Irf7 Traf6 Ube2n GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) Sap30l Suds3 Nfatc2 Sap30 Sap18b Prdx2 Arid4b Jun Prdx1 Angptl4 Sod2 Cdk5r1 Bcl2l11 Ywhae Cdk5 Fasl Cdc25c Sympk Foxo3 Cstf1 Papola Clp1 Nudt21 Cpsf1 Cstf2 Cpsf2 Cstf3 Cpsf3 Cstf2t Wdr33 Notch1 Rbx1 Ihh Lpl Crh Zfp457 Gad1 Gad2 Cdc73 Rtf1 Leo1 Skic8 Ccne1 Ctr9 Ccne2 Paf1 Fzr1 Tfdp2 Tfdp1 Skp2 Rb1 Ccnd2 Ccnd3 Ccnd1 Cdk6 Cdk4 Cdk2 E2f1 Cdkn1a Daxx Cdkn1b Mybbp1a Ppp2cb Ss18 Ppp2ca Dpf1 Dpf2 Dpf3 Ss18l1 Bcl7a Bcl7b Bcl7c Ppp2r1b Ppp2r1a Birc5 Aurkb Ppp2r5c Spocd1 Dnmt3l Rrp8 Msh2 Pms2 Mlh1 Mta1 Tjp1 Mta3 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Agpat2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Ercc2 Adipoq Ccnh Rnmt Ercc3 Cdk7 Rngtt H2ac20 Prkaa1 Prkaa2 Myc Henmt1 Asz1 Akt3 Akt2 Tdrd1 Mov10l1 Akt1 Tdrd12 Mybl1 Nfix Fkbp6 Piwil4 Ssb Tdrkh Nfia Nfic Piwil2 Piwil1 Tcf7l1 Tdrd9 Tcf7l2 Tdrd6 Ddx4 Mael Mov10 Yes1 H2ac12 H2ac11 Ago4 Ago3 Plin2 Ago2 Ago1 H2ac15 H3c7 Ezh2 H2ax Csnk2a2 Tead4 Suz12 Ash2l Hist1h2bp Fos H2aj Pdk4 Yap1 Ctla4 H2bc9 H2bc7 H2bc8 H2bc3 Tead3 Tead2 Tead1 Stat1 Rictor H2ab2 Kdm6a Uhrf1 Tet3 H2bu2 Tcf7 Prkag3 Prkag1 Prkag2 Wwtr1 Kmt2c Hist2h2aa1 Prr5 Ywhag Pdpk1 Dpy30 Wdr5 Csnk2b Eed Phf1 Tet2 Tet1 Gsk3b Mtf2 Ipo8 Mlst8 Ezh1 Mterf1b Lef1 Jarid2 Phf19 H2bc14 Epop Mtor Ptpn11 H2bc21 Tfb2m Tnrc6c Tfam H2bc26 Pagr1a Rbbp5 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Mapkap1 Prkab2 Prkab1 Ell Nelfa Ajuba Nelfb Nelfe Taf15 Ctdp1 Taf11 Taf13 Taf12 Ccnk Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Taf9 Ncbp2 Ncbp1 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Taf8 Eloa Taf7 Taf6 Eloc Taf5 Taf4 Taf3 Taf2 Taf1 Plin1 Mgll Fabp4 Actb Lpin1 Dgat2 Lipe Trp53 Psip1 Hsp90aa1 Tgfb1 Cpsf4 Parp1 Pabpn1 Ran Blk Elf1 Elf2 Cbfb Pax5 Cebpa Sox2 Znf521 Tsnax Prkra Dicer1 Tarbp2 Tsn Trpc3 Tasp1 Akap8l Pex11a Kat8 Yeats2 Wdr82 Kat14 Hcfc2 Dr1 Phf20l1 Elovl5 Cidec Tada3 Tada2a Bod1 Zzz3 Plin4 Acsl1 Mbip Kansl3 Kansl1 Kansl2 Pnpla2 Bod1l Thrsp Phlda1 Sgf29 Prkcq Ywhah Hdac1 Sox9 Kit Ywhaz Pomc Cav1 Cga Cpsf7 Furin Rptor Ppm1a Slc38a9 Lamtor5 Sf3b1 Lamtor4 Rraga Rragb Lamtor1 Rragc Lamtor2 Rragd Tsc2 Srrt Tsc1 Stk11 Dnmt3a Scd1 Dnmt3b Dnmt1 Nfyb Nfya Nfyc Gpam Sp1 Elac2 Ang Trp63 Tnfrsf10b Aff4 Supt6 Iws1 Mllt3 Mllt1 Eaf1 Itch Casp1 Stub1 Bax Fas Ogt Cd36 Suv39h1 Setdb1 Aebp2 Atf7ip Camk2g Camk2d Camk2b Camk2a Prkaca Cdkn2a Cdkn2b Ehmt2 Ehmt1 Txn Il6 Ring1 Cbx8 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Mdm2 Mdm4 Ccna1 Ccna2 Bmi1 Cebpb Map2k6 Rnf2 Mapkapk5 Bdnf Mphosph8 Grin2b Morc2a Jag1 Dll1 Snrpb Prmt5 Phax Snrpd3 Phf20 Pcbp4 Chek2 Zfp385a Snapc5 Snapc3 Snapc4 Snapc1 Snapc2 Znf143 Brf2 Grin2a Camk4 Plk2 Gamt Myl12a Erbb2 Gls Itgbl1 Myb Zfp839 Cldn5 Ddit4 Ddit3 Txnip Med8 Bcdin3d Retn Drosha Med4 Xpo5 Med6 Ell2 Lgals3 Ell3 Zfp825 Rprd1a Axin1 Rprd1b Gata3 Ints4 Gata4 Ints5 Pip4k2b Ints6 Gata1 Ints7 Gata2 Ints8 Pip4k2a Ints9 Higd1c Ints1 Cited4 Ints2 Cited1 Ints3 Cited2 Nabp1 Zfp819 Nabp2 Nfe2 Pou2f2 Plk3 IntS13 Cdc7 Ints14 Cdk13 Ints11 Cdk12 Ints12 Abca6 Ints10 mt-Co2 Zc3h8 mt-Co3 Polr3gl Rprd2 Gatad2a Gtf3a Rpap2 Junb Crcp Ice1 Gatad2b Polr3a Ice2 Ret Polr3d Ssu72 Gpi Brf1 Btg2 Polr3e Btg1 Polr1c Chm Polr3b Zfp872 Polr3c Gli3 Polr3h Gli2 Polr3f Ing5 Polr1d Ing2 Polr3g Rarb Polr3k Zik1 Gtf3c2 Brd2 Gtf3c1 Ppard Gtf3c4 Zfp867 Gtf3c3 Zkscan16 Gtf3c6 Tal1 Gtf3c5 Wwox Bdp1 Gps2 Zfp616 Rybp Tcf12 Zfp612 Brd7 Zfp619 Pf4 Kat2b Rarg Fancd2 Kat2a Wwp1 Zfp605 Atad2 Zfp606 Atxn3 Socs3 Gprin1 Smyd2 Socs4 Trp53rkb Men1 Zfp30 Usp2 Zfp37 Usp7 Pvalb Gria2 Csf2 Zfp69 Sesn2 Coxfa4 Cnot11 Sesn3 Itga5 Tfap2c Tfap2d Csf1r Tfap2a Tfap2b Setd1b Steap3 Itga4 Setd1a Tfap2e Cnot10 Abl1 Brpf3 Brpf1 Npas4 Zfp51 Kat6a Cdk8 Bcl6 ZNF418 Znf354c Znf354b Zfp84 Sin3a Sin3b Tnks1bp1 Il2ra Itgal Lbr Zfp90 Zfp78 Gpx2 Hand2 Iqsec3 Skil Pink1 Gls2 Dgcr8 Ptpn4 Ptpn1 Cox7a1 Cox7a2 Rnf34 Atp1b4 Klf4 Pitx2 Pml Ins2 Nkx2-5 Zfp157 Zfp398 Cox7a2l Zfp141 Cnot6l Actl6a Actl6b Smarce1 Apaf1 Rffl Znf382 Cradd Pidd1 Havcr2 Rnf111 Znf394 Tpx2 Tmem219 Zfp369 Banp Esrra Fanci Pbrm1 Esrrb Esrrg Fancc Zfp180 Zfp189 Zfp184 Fkbp5 Sgk1 Ccng2 Znf2 Zfp175 Pou2f1 Znf583 Npy Vegfa Satb2 Zfp169 Ncoa3 Lifr Zfp791 Zfp790 Nr5a2 Zfp317 Zfp558 Zfp799 Lmo2 Lmo1 Zfp300 Zfp786 Ttf1 Polr1b Ube2d3 Polr1a Znf569 Polr1g Nop2 Polr1e Arid2 Polr1h Znf775 Sap30bp Zfp777 Nedd4l Taf1d Yeats4 Taf1a Fbxo32 Taf1c Cbx5 Taf1b Sap130 Cbx3 Irak1 Baz2a Ubtf Znf551 Esr2 Zfhx3 Zfp764 Auts2 Jmy Ndrg1 Zfp111 Zfp597 Zfp113 Zfp112 Ybx1 Znf750 Tgif1 Tgif2 Ifng Kcnip3 Nr1d2 Kctd15 Mybl2 Znf771 Kdm5b Znf770 Rbl2 Itga2b Trim63 Dyrk2 Trp53inp1 Rbl1 Aurka Trim28 Zfp334 Hes1 Thra Zfp563 Slbp Dek Lsm10 Trim33 Lsm11 Zfp560 Zfp566 Zfp324 Prdm1 Mdc1 Spi1 Nampt Zfp712 Rrn3 Ercc6 Znf710 Zfp711 Twist2 Znf18 Twist1 Zfp703 Zfp709 Zfp706 Zfp708 Zfp707 Maml1 Maml2 Mtrex Hdac11 Hdac10 Sfn Rbpj L3mbtl2 Zfp354a L3mbtl1 Znf704 Med23 Med24 Med25 Med20 Ddb2 Zscan25 Hey2 Hey1 Med26 Med27 Med12 Mmp13 Med13 Med14 Med10 Zfp740 Rspo3 Zfp746 Usp9x Med15 Med16 Krba1 Med17 Ncor2 Aifm2 Zcchc8 Htt Zfp735 Pcgf6 Rbm7 Pcgf2 Pcgf5 Spp1 Bid Mbd3 Pphln1 Ucma Yy1 Ski Tigar Tnfrsf18 Hipk1 Hipk2 Srebf1 Mamld1 Cox6a1 Cox6a2 Rabggta Rabggtb Agrp Arid1a Arid1b Ppp1r13l Serpinb13 Kmt5a Egfr Ppp1r13b Maf Serpine1 Max Dlx5 Rgcc Sp7 Cpap Cnot3 Cnot2 Cnot1 Cnot7 Polrmt Cnot6 Med30 Med31 Cnot4 Ddx21 Rorc Cnot9 Cnot8 Rorb G6pc1 Kmt2d Cox6b1 Cox6b2 Kmt2b Pin1 Trp53bp2 Rrm2b Syt10 Hivep3 Hdac2 Hdac5 Smarcb1 Foxg1 Slc2a3 Hdac7 Hdac6 Yaf2 Hdac9 Hdac8 Mobp Smarca2 Triap1 Smarca4 Nrbp1 Srf Arnt Prelid3a Smarcd1 G6pdx Smarcd2 Mga Pten Tbx5 Sst Smarcc2 Smarcc1 Nlrc4 Ppm1d E2f4 E2f5 E2f6 E2f7 E2f8 Uxt Rbfox1 Rbfox3 Epc1 Ccn2 Col1a2 Col1a1 Zfp2 Zfp1 Ccnc Zfp266 Zfpm1 Thbs1 Zfp9 Znf263 Pck1 Pip4p1 Cox8a Zfp248 Apoe Nuak1 Hnf4a Ctsk Ctsl Prmt6 Cox7b Prmt1 Hnf4g Psma4 Foxo4 Gp1ba Psma3 Bcl2l14 Psma6 Foxo1 Psma5 Zkscan8 Psma2 Tgfa Psma1 Zkscan1 Znf250 Zkscan4 Psmd12 Zkscan5 Psmd11 Znf496 Psmd14 Zkscan3 Psmd13 Bnip3l Nfkb1 Smurf2 Skp1 Smurf1 Foxp3 Psmb5 Nr4a3 Psmb4 Hcfc1 Nr4a1 Psmb7 Zfp27 Psmb6 Zfp28 Psmb1 Runx3 Psmb3 Cox5a Psmb2 Zfp11 Zfp12 Zfp13 Rela Npm1 Prkcb Zfp14 Mstn Psma7 Zfp287 Psmc6 Zfp286 Psmc5 Ppargc1b Psmc2 Zfp282 Psmc1 Gck Psmc4 Ttc5 Psmc3 Kctd6 Ubc Nr2c2 Kctd1 Psmd7 Znf436 Psmd6 Zfp677 Pou4f1 Pou4f2 Psmd8 Msx2 Psmd3 Plxna4 Psmd2 Znf692 Psmd1 Gem Zfp426 Adrm1 Rxrb Sem1 Znf689 Cul1 Zfp664 Perp Oprm1 Sirt3 Trp73 Nr3c1 Rxrg Thrb Il2 Nr2c1 Zfp655 Vdr Smad1 Smad2 Nr1h2 Bmp2 Mbd2 Rora Smad3 Ppara Smad4 Esr1 Znf667 Pparg Nppa Znf668 Tcf3 Ar Smad6 Rxra Smad7 Hdac4 Ldb1 Ube2i mt-Co1 Rara Zfp473 Pgr Txnrd1 Nr5a1 Zfp235 Meaf6 Nr4a2 Cox4i1 Kat5 Cox4i2 Exo1 Hspd1 Nr2f6 Nr0b2 Nbn Cxxc1 Nr2f1 Znf641 Rfc5 Notch4 Rbm14 Prelid1 Rfc3 Chd3 Pcna Chd4 Rfc4 Notch2 Cat Notch3 Rfc2 Nr2e1 Nkx3-2 Gadd45a Hus1 Zfp454 Atrip Zfp212 Brip1 Zfp691 Dna2 Igfbp3 Rest Zfp213 Rad51d Zfp697 Cavin1 Igfbp1 Blm Zfp458 Kras Chek1 Mta2 Rrm2 Rad9a Casp6 Bard1 Casp2 Rad9b Nr2c2ap Top3a Zfp445 Zfp202 Wrn Zfp688 Mre11a Zfp446 Oprk1 Rad51 Rad50 Rpa1 Topbp1 Rpa2 Rad17 Rbbp8 Brca1 Rpa3 Rad1 Atm Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdk1 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Src Ctnnb1 Fip1l1 Met Mapk1 Mapk3 Ywhab Mapk14 Mapk11 Ncor1 Atf2 Carm1 Paxip1 Ep300 Tbl1x Baz1b Bmal1 Hdac3 Ncoa2 Smarca5 Ncoa1 Xpo1 Tbl1xr1 Smarcd3 Ncoa6 Med1 Nr1d1 Ppargc1a Crebbp Mef2c Sirt1 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 Trp53 Cdkn1a Pcbp4 Zfp385a SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease Stat5a Cep43 Stat5b Stat3 Stat1 Polr2c Zmym2 Polr2d Pik3ca Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 Fgf16 Frs2 Fgf18 Fgf2 Fgf1 Bcr Nras Fgf4 Gab1 Fgf10 Plcg1 Fgf3 Fgf6 Sos1 Bag4 Fgf7 Fgf9 Fgfr3 Hras Fgf20 Gab2 Fgf23 Fgfr4 Fgfr1 Fgf22 Erlin2 Fgfr2 Myo18a Cux1 Fgfr1op2 Cpsf6 Ncbp2 Ncbp1 Pik3r1 Trim24 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 96%9769726 Defects of Coagulation cascade Ano6 F2 Fgb Fga Vwf F5 Fgg F8 F9 Gp1ba Ggcx Pros1 Gp9 Gp1bb Gp5 F10 Tpst1 Tpst2 Proc PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy Map1lc3b Usp30 Pex5 Sqstm1 Epas1 Nbr1 Atm Ubc SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 96%9842640 Signaling by LTK in cancer Pik3ca Clip1 Mapk1 Mapk3 Pik3r1 Pik3cb Pik3r2 NETRIN MEDIATED REPULSION SIGNALS%REACTOME%R-HSA-418886.3 Netrin mediated repulsion signals Unc5a Dcc Src Unc5d Unc5c Ntn1 Unc5b Ptpn11 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade Tlr4 Irf7 App Ikbkb Jun Birc3 Birc2 Traf3 Ikbkg Map3k7 Ticam2 Traf2 Ticam1 Cd14 Ikbke Tank Optn Nfkb1 Skp1 Fadd Fbxw11 Rela Ripk3 Btrc Casp8 Ripk1 Ube2d3 Ubc Nfkbib Irak1 Nfkbia Cul1 Traf6 Ube2n Chuk Ube2v1 Trp53 Tab3 Tab2 Tab1 Rps6ka1 Tifa Alpk1 Nfkb2 Fos Mapk9 Mapk7 Mapk8 Elk1 Map3k8 Ube2d1 Mapk1 Mapk3 Rps6ka3 Mapkapk3 Rps6ka2 Mapkapk2 Map2k7 Mapk14 Map2k6 Ppp2cb Ppp2ca Map2k4 Map2k3 Mapk10 Map2k1 Mapk11 Ptpn11 Ripk2 Tbk1 Rps6ka5 Irf3 Nkiras1 Atf2 Nkiras2 Lrrc14 Vrk3 Ikbip Ppp2r1b Ppp2r1a Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Usp18 Ppp2r5d Ly96 Mef2c PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC Tubb6 Tubb3 Tubb1 Pfdn6 Cct6a Pfdn5 Pfdn4 Tubb4b Tubb4a Tuba1a Pfdn2 Pfdn1 Tuba1c Cct3 Cct2 Tubb2b Vbp1 Tubb2a Actb Tcp1 Tuba4a Cct6b Tuba3b Cct8 Cct7 Cct5 Cct4 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 96%1428517 Aerobic respiration and respiratory electron transport Cox14 Ndufv2 Ndufv1 Ndufv3 Cox16 Cox18 Tmem177 Ndufc1 Ndufc2 Ndufs1 Ndufs2 Ndufs5 Ndufs7 Ndufs8 Foxred1 Ndufa1 Ndufa3 Ndufa2 Ndufa7 Ndufa6 Ndufa9 Ndufa8 Sucla2 Ndufb2 Idh3a Ndufb3 Ndufb6 Etfa Ndufb5 Ndufb7 Idh3b Ndufb9 Etfb Vdac1 ATP6 Atp5f1d Atp5pb Ranbp9 Atp5f1c Atp5pf mt-Nd4 mt-Nd5 mt-Nd6 mt-Nd1 Atp5mc3 mt-Nd2 Atp5mf mt-Nd3 Hspa9 Atp5me Dmac2l Atp5f1b Atp5f1a Atp5mk Gstz1 Slc25a4 Pm20d1 Me1 Got1 Got2 Pcx Adhfe1 L2hgdh D2hgdh Cox6a1 Cox6a2 Acat1 Ogdh Dlst Cox6b1 Cox6b2 Ecsit Slc25a27 Ucp2 Ucp3 Slc25a14 Cox8a Cox7b Cox5a Ucp1 Mdh1 Mdh2 Slc25a18 Slc25a11 Slc25a22 Ubc Slc25a12 Slc25a13 Sirt3 Cox15 mt-Co1 Cox4i1 Cox4i2 Cox19 Cox17 Aco2 Cs Timm21 Pdhx Ldhal6b Glo1 Gpt Wdr26 Idh3g Pdha1 Pdha2 Mpc1 Ndufb8 Mpc2 Pdk4 Nek1 Pdk3 Mkln1 Pdk2 Pdk1 Pdhb Pdp1 Fahd1 Pdp2 Pdpr Gid4 Maea Higd1c Ldha Ldhb Gid8 Ldhc Armc8 Me3 Dlat Me2 Rmnd5a Rmnd5b Sirt4 mt-Co2 mt-Co3 Ndufab1 Cyc1 Uqcrq Lyrm7 Hscb Uqcrc2 Uqcrc1 Lyrm4 Uqcrfs1 Uqcc2 Uqcc3 Uqcrb Uqcc1 Uqcc6 Uqcr10 mt-Cytb Fxn Bcs1l Ttc19 Uqcrh Oxa1l Coxfa4 Smim20 Suclg1 Nubpl Suclg2 Cmc1 Tmem223 Isca2 Sco1 Coq10a Etfdh Coq10b Rab5if Trap1 Sdhaf1 Sdhaf2 Sdhaf3 Sfxn4 Sdhaf4 Surf1 Higd2a Ndufa12 Ndufa10 Nnt Timmdc1 Ndufa13 Ndufb11 Ndufb10 Dld Fh Hccs Lyrm2 Dmac2 Dmac1 Ndufaf7 Ndufaf6 Ndufaf5 Tmem186 Ndufaf4 Ndufaf8 Sdhd Sdhc Ndufaf3 Sdhb Cox7a1 Sdha Cox7a2 Ndufaf2 Letm1 Ndufaf1 Tmem126b Tmem126a Acad9 Cox20 Taco1 Ndufa5 Coa3 Idh2 Cox7a2l Cox11 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Rsu1 Tesk1 Actn1 Parvb Arhgef6 Parva Pxn TYROSINE CATABOLISM%REACTOME%R-HSA-8963684.5 Tyrosine catabolism Hgd Tat Fah Hpd Gstz1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling Nrg3 Nras Nrg1 Sos1 Hras Egfr Erbb2 Egf Ereg Hbegf Btc Nrg2 Nrg4 IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) Tlr5 Myd88 Irak4 GSD XV%REACTOME%R-HSA-3814836.4 GSD XV Gys1 Gyg1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-HSA-1799339.4 SRP-dependent cotranslational protein targeting to membrane Rps5 Rpl24 Sec61b Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Sec11c Rpl17 Sec11a Rpl18 Rpl19 Rpl10l Rpl11 Srp68 Rps3 Ssr4 Rps4x Ssr3 Ssr2 Srp72 Srp9 Tram1 Srp14 Srp54 Srp19 Ddost Srprb Srpra Rpn2 Rps27 Rpn1 Ssr1 Rps14 Rpl4 Rps16 Spcs3 Rps18 Spcs1 Rps19 Spcs2 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Sec61a2 Sec61a1 Rpl32 Rps9 Rps7 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 96%198725 Nuclear Events (kinase and transcription factor activation) Fosb Mapk7 Elk1 Nab1 Nab2 Cdk5r1 Junb Trib1 Arc Tph1 Cdk5 Id2 Id3 Fosl1 Sgk1 Egr3 Egr4 Lyl1 Ascl1 Rrad Cdk5r2 Sh3gl3 F3 Vgf Tcf12 Dnm2 Mapk1 Mapk3 Rps6ka3 Rps6ka2 Mapkapk2 Mapk14 Ppp2cb Ppp2ca Egr2 Mapk11 Rps6ka5 Atf2 Jund Rps6ka1 Vrk3 Srf Ep300 Egr1 Ppp2r1b Ppp2r1a Chd4 Mef2d Id4 Id1 Dusp3 Dusp4 Rest Dusp7 Dusp6 Mef2a Fos Ppp2r5d Mef2c RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 96%5625900 RHO GTPases activate CIT Myl6 Myh14 Rhob Dlg4 Myh10 Myh9 Rhoc Rhoa Myl12a Ppp1r12b Kif14 Ppp1r12a Myl12b Rac1 Cit Myh11 Cdkn1b Prc1 Ppp1cb CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 96%211897 Cytochrome P450 - arranged by substrate type Cyp51a1 Cyp2r1 Cyp2u1 Cyp1b1 Cyp4a32 Cyp2w1 Cyp4f15 Cyp2s1 Ahr Cyp2d22 Cyp3a16 Cyp3a13 Cyp3a57 Cyp2c65 Cyp2c55 Cyp2j6 Cyp2f2 Cyp2e1 Cyp1a1 Adh7 Cyp2b10 Ahrr Cyp4f14 Cyp2c50 Ptgis Cyp1a2 Tbxas1 Cyp2a5 Cyp8b1 Cyp4v3 Cyp39a1 Por Cyp11b1 Cyp27b1 Cyp46a1 Nr1h4 Cyp4f39 Cyp4f17 Cyp27a1 Cyp24a1 Cyp7a1 Cyp4a12b Cyp7b1 Cyp4f3 Cyp4f40 Cyp4b1 Fdx1 Fdxr Fdx2 Rxra Cyp19a1 Arnt Cyp21a1 Cyp11b2 Pomc Cyp26b1 Cyp26c1 Ncoa2 Cyp26a1 Ncoa1 Cyp11a1 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%5652084 Fructose metabolism Khk Sord Akr1b1 Aldh1a1 Tkfc Aldob Glyctk DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production Nfkb2 Myd88 Rela Nfkb1 Irf7 Dhx9 Dhx36 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.5 Cardiac conduction Npr1 Npr2 Corin Nppc Kcnk1 Kcnk7 Kcnk6 Scn9a Scn5a Scn1a Scn1b Kcnip4 Kcnip1 Scn10a Scn2a Scn2b Scn7a Scn11a Scn3a Scn3b Nppa Kcnip3 Scn8a Fgf14 Cacng6 Cacna1c Scn4a Fgf12 Fgf13 Scn4b Fgf11 Ryr2 Fkbp1b Ryr1 Atp2a1 Dmpk Atp1a2 Fxyd4 Atp1a1 Atp2a3 Fxyd1 Atp2a2 Atp1a3 Fxyd7 Sri Fxyd6 Kcnk5 Trdn Kcnk12 Kcnk15 Camk2g Ryr3 Camk2d Ahcyl1 Camk2b Asph Camk2a Nos1 Slc8a1 Slc8a2 Atp1b1 Slc8a3 Atp1b3 Atp2b2 Cacna2d2 Atp1b2 Atp2b1 Atp2b4 Atp2b3 Orai1 Orai2 Prkaca Cacnb1 Gata4 Stim1 Cacnb2 Cacng8 Tnni3 Cacng4 Kcnj11 Abcc9 Itpr3 Itpr2 Itpr1 Kcnj2 Hipk1 Hipk2 Kcnj4 Kat2b Wwtr1 Ces1d Mme Kcnj12 Kcnh2 Kcnq1 Kcna5 Kcnd3 Kcnd2 Kcnd1 Kcnk13 Kcnk10 Kcnk16 Kcnk18 Kcnk4 Kcnk3 Kcnk2 Tbx5 Kcnk9 Kcnj14 Cacng7 Kcne5 Kcne4 Kcne3 Kcne2 Kcne1 Akap9 Nkx2-5 Trpc1 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors Ffar3 Ffar4 Ffar1 Gpr31 Ffar2 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 96%9026527 Activated NTRK2 signals through PLCG1 Bdnf Plcg1 Ntf4 Ntrk2 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%438064 Post NMDA receptor activation events Prkaca Dlg1 Camkk1 Dlg3 Camkk2 Dlg4 Prkx Gria1 Rasgrf1 Rasgrf2 Prkacb Src Nrg1 Adcy1 Rps6ka6 Prkag3 Adcy8 Prkag1 Prkag2 Mapk1 Mapk3 Nrgn Rps6ka3 Pdpk1 Rps6ka2 Prkar1b Git1 Prkar2b Gria2 Nras Hras Prkaa1 Grin2b Prkaa2 Prkar1a Rps6ka1 Grin2a Prkab2 Camk4 Prkab1 Camk1 Dlg2 Actn2 Prkar2a Nefl Grin1 Grin2d Grin2c Camk2g Camk2d Camk2b Rac1 Camk2a DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665737 Drug resistance in ERBB2 TMD JMD mutants Erbb2 Cdc37 Erbin Hsp90aa1 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-HSA-9034793.3 Activated NTRK3 signals through PLCG1 Ntrk3 Plcg1 Ntf3 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins Vps28 Ubap1 Tsg101 Mvb12a Mvb12b Vps37a Vps37b Vps37c Nmt2 Vps37d Ubc ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 96%187015 Activation of TRKA receptors Adcyap1r1 Ngf Ntrk1 Ntrk2 Adora2a Adcyap1 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9831926 Nephron development Dll1 Wnt4 Wnt9b Pou3f3 Irx1 Hnf4a Irx2 Wt1 Lfng Jag1 Lhx1 Hnf1b NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 Psen2 Ncstn Aph1b Notch3 Ybx1 Psen1 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK Strada Slc38a9 Lamtor5 Lamtor4 Rraga Mlst8 Rragb Lamtor1 Rragc Lamtor2 Rragd Mtor Tsc2 Tsc1 Prkaa1 Stk11 Prkaa2 Cab39l Prkab2 Prkab1 Prkag3 Prkag1 Prkag2 Rptor Ppm1a Stradb Cab39 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%350054 Notch-HLH transcription pathway Hdac2 Hdac1 Hdac5 Hdac4 Ncor2 Hdac7 Hdac6 Hdac9 Ncor1 Hdac8 Notch4 Tbl1x Notch2 Notch3 Mamld1 Hdac3 Notch1 Tbl1xr1 Kat2b Maml1 Maml2 Hdac11 Kat2a Hdac10 Rbpj Crebbp RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation Snapc5 Snapc3 Snapc4 Snapc1 Snapc2 Znf143 Brf2 Polr3gl Gtf3a Crcp Polr3a Polr3d Nfix Brf1 Ssb Polr3e Nfia Polr1c Nfic Polr3b Polr3c Polr3h Polr3f Pou2f1 Polr1d Polr3g Polr3k Gtf3c2 Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 Gtf3c5 Bdp1 Tbp Polr2h Polr2e Polr2f Polr2k TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules Nceh1 Angptl8 Angptl4 Angptl3 Apobr Ap2m1 Ldlrap1 Amn Soat2 Nr1h3 Soat1 Mttp Lsr Prkacb Abcg1 Lcat Fgf21 Mylip Slc44a3 Slc5a7 Ap2a2 Npc2 Slc44a4 Slc44a5 Ap2a1 Npc1 Slc10a6 Slc44a1 Apoa2 Ldlr Slc44a2 Adcy3 Hdlbp Adcy4 Apoa4 Adcy1 Apoa5 Afg3l2 Adcy2 Creb3l3 Smdt1 Adcy7 Lmf1 Adcy8 Lmf2 Mcub Adcy5 Pmpcb Lpl Gpihbp1 Adcy6 Vdac2 Yme1l1 Ap2b1 Ces3b Vdac3 Adcy9 Ap2s1 Spg7 Apoc1 Micu2 Apoc2 Micu3 Lipa Pmpca Lipg Vdac1 Phb2 Abca1 Lipc Slc22a5 Micu1 Parl Alb Pcsk9 Maip1 Vldlr Stoml2 Apoc3 Mcu Apoc4 Apof Akap1 Prkar1b P4hb Slc8b1 A2m Cubn Prkar2b Gng10 Slc12a1 Slc12a4 Gng3 Slc12a5 Gng2 Slc12a2 Slc12a3 Slc12a6 Slc35d2 Gng4 Slc12a7 Gng7 Ryr2 Gng8 Fkbp1b Ryr1 Atp2a1 Atp1a2 Fxyd4 Atp1a1 Slc26a11 Atp2a3 Fxyd1 Gngt1 Atp2a2 Gngt2 Atp1a3 Fxyd7 Sri Slc4a7 Fxyd6 Aqp8 Trdn Camk2g Ryr3 Abcc3 Camk2d Camk2b Asph Camk2a Slc8a1 Gnb2 Slc8a2 Slc2a4 Atp1b1 Gnb1 Slc8a3 Gnb4 Atp1b3 Gnb3 Atp2b2 Gnb5 Atp1b2 Gng11 Atp2b1 Atp2b4 Gng12 Atp2b3 Gng13 Slc16a3 Emb Slc16a8 Prkaca Slc16a7 Kcnj11 Abcc9 Slc25a10 Slc17a5 Abcb10 Abcf1 Abcb5 Abcb8 Abcb9 Abcg4 Pex3 Abca8b Abcc10 Abcd2 Abcd3 Abca2 Abca5 Rhcg Abca4 Rhbg Abca9 Abcc1 Abca7 Slc26a2 Slc26a1 Slc5a8 Asic5 Asic4 Atp10a Slc24a1 Atp10b Atp10d Atp8a1 Asic1 Slc35b3 Atp8a2 Clcn2 Slc35b2 Clcn3 Slc9c1 Clcn1 Atp4a Atp4b Atp11b Slc2a1 Atp11a Atp13a1 Atp11c Atp8b2 Atp8b1 Atp8b3 Atp13a2 Atp13a4 Atp13a5 Atp12a Wnk4 Atp9b Atp9a Nalcn Tsc22d3 Wnk1 Wnk3 Wnk2 Slc9b1 Best1 Slc9b2 Best3 Clcnkb Best2 Clcnka Atp7b Clca1 Clca2 Atp7a Stoml3 Cutc Ano10 Ano8 Ano7 Ano6 Ano5 Clcn6 Ano4 Ano2 Ano1 Ttyh3 Ttyh2 Sgk3 Sgk2 Atp2c1 Atp2c2 Scnn1a Scnn1b Unc79 Scnn1g Slc17a3 Ostm1 Tpcn1 Eif2s3x Rab11a Tpcn2 Eif2s2 Clcn7 Eif2s1 Clca4a Aqp9 Clcn4 Aqp7 Clcn5 Bsnd Slc35a3 Slc43a1 Slc43a2 Avpr2 Slc7a11 Slc7a10 Slc1a1 Slc25a29 Slc3a1 Slc38a5 Avp Slc1a3 Slc38a4 Slc1a2 Slc1a5 Slc38a3 Slc38a2 Slc36a4 Slc1a4 Slc3a2 Slc1a7 Slc1a6 Slc7a3 Slc7a1 Slc6a6 Slc6a19 Slc7a6 Slc7a7 Slc7a5 Slc6a15 Slc38a1 Slc6a14 Slc36a2 Abcg8 Slc7a8 Abcg5 Slc36a1 Slc7a9 Slc6a12 Slc6a20a Erlin2 Erlin1 Prkar1a Zdhhc8 Apod Cftr Slco1a4 Slc22a8 Slc22a15 Slc47a1 Os9 Slc14a2 Slc25a26 Slc22a4 Slc22a16 Slc14a1 Sel1l Magt1 Abca6 Rnf185 Derl3 Derl2 Derl1 Vcp Cyb5r4 Cyb5r2 Ca1 Cyb5r1 Ca2 Ca4 Tusc3 Cyb5rl Rhag Wwp1 Slc4a1 Aqp1 Erlec1 Slc30a5 Slc30a8 Rnf5 Steap3 Plekha8 Letm1 Esyt1 Slc17a8 Sgk1 Arl2 Nedd4l Slco4c1 Nipal4 Abca3 Nipal2 Nipal3 Slc2a13 Nipal1 Slc5a11 Slco2b1 Slc5a3 Slc27a1 Slc39a3 Slc16a2 Slc39a2 Slc39a1 Slc39a8 Slc39a7 Slc39a6 Slc39a5 Slc35d1 Slc2a12 Slc28a1 Dmtn Fbxl5 Slco4a1 Nipa1 Nipa2 Slc17a1 Esyt3 Esyt2 Slc29a4 Slc30a10 Slc25a1 Slc26a6 Slc26a9 Slc26a7 Pip Rab11fip2 Slc27a6 Slc35b4 Slc5a10 Slc5a12 Slc2a6 Slc2a7 Slc39a14 Ngb Slc39a10 Mb Ank Slc25a5 Prkar2a Slco1c1 Ahcyl2 Slc25a4 Slc13a5 Slc13a3 Slc13a4 Slc13a1 Slc13a2 Slc4a10 Aqp6 Cygb Aqp5 Slc35a1 Aqp4 Slc6a11 Aqp3 Slc6a13 Aqp2 Slc4a2 Slc4a3 Slc22a2 Slc4a5 Slc22a1 Slc4a8 Slc4a9 Slc6a1 Mip Slc6a4 Slc45a3 Slc22a6 Myo5b Lcn12 Slc11a1 Gltp Slc5a9 Mrs2 Arl2bp Azgp1 Slc31a1 Slc20a1 Slc66a1 Slc32a1 Slc5a4a Slc41a2 Slc41a1 Mmgt1 Slc30a3 Slc30a2 Slc35c1 Slc30a1 Aqp12 Aqp11 Slc50a1 Add2 Lrrc8e Cptp Lrrc8a Lrrc8b Cln3 Lrrc8c Lrrc8d Clta Cltc Arf1 Slc5a6 Pdzd11 Slc6a7 Slc6a9 Slc17a6 Slc15a1 Ctns Slc15a3 Slc15a4 Slc2a3 Abcc2 Add3 Trpv5 Trpv4 Trpv6 Trpc6 Trpc5 Trpc7 Mcoln3 Trpc1 Trpc4 Trpc3 Trpa1 Trpv1 Apoe Trpv3 Mcoln1 Mcoln2 Trpv2 Trpc4ap Trpm2 Trpm1 Trpm8 Trpm7 Psma4 Trpm4 Trpm3 Psma3 Trpm6 Psma6 Trpm5 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Slc2a8 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Slc25a18 Psmc4 Slc25a11 Psmc3 Slc25a22 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Slc2a9 Adrm1 Sem1 Cul1 Nr1h2 Add1 Abcb6 Abcb4 Bsg Slc4a4 Stom Slc33a1 Abcc6 Slc26a4 Slc26a3 Slco2a1 Phb1 Slc5a5 Slc27a4 Slc24a3 Slc39a4 Slc24a2 Slc6a2 Slc6a5 Slc2a10 Slc16a1 Slc35a2 Slco1b2 Slc24a5 Abca12 Abcc4 Slc20a2 Slc24a4 Abcc5 Slc22a12 Slc29a3 Slc29a2 Slc28a3 Slc28a2 Raf1 Slc29a1 Atp6v0b Hfe Atp6v0a2 Slc40a1 Atp6v0a4 Abcd1 Atp6v1g3 Cp Hmox2 Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Tf Ftl1 Glrx3 Fth1 Furin Cybrd1 Cand1 Pcsk5 Pcsk6 Abcg2 Ftmt Tfr2 Atp6ap1 Atp6v1e2 Atp6v1e1 Steap4 Slc22a17 Tcirg1 Slc11a2 Tfrc Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Ireb2 Heph Atp6v1f Atp6v1d Nedd8 Lcn2 Atp6v1h Slc9a4 Slc9a5 Slc46a1 Slc9a2 Slc9a3 Slc9a8 Slc9a9 Slc9a6 Slc9a7 Hmox1 Slc34a1 Slc9a1 Slc34a3 Slc34a2 Sar1b Slc2a2 Slc5a1 Slc22a3 Slc6a3 Hba-a1 Abcb1a Hbbt1 Pex19 Slc22a18 Mbtps1 Mbtps2 Apoa1 Apob SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 96%194315 Signaling by Rho GTPases Plxnd1 Dlg4 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Ywhae Btk Dvl1 Dvl2 Cdc25c Dvl3 Lmnb1 Arpc3 Arpc2 Flot2 Flot1 Cyfip2 Arpc5 Arpc4 Dock7 Mrtfa Senp1 Samm50 Nckipsd Was Wasf3 Mtx1 Wasl Ptpn13 Wwp2 Cdc42bpa Cdc42bpb Rhoj Slc4a7 Fnbp1 Dock8 Fnbp1l Cpne8 Scrib Fmnl3 Nipsnap2 Rasal2 Cul3 Ppp1r12b Ppp1r12a Ppp1r14a Arhgef9 Lin7b Rasgrf2 Pard6b Cdkn1b Abcd3 Clasp1 Clasp2 Pafah1b1 Nup37 Zw10 Farp2 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Tiam1 Sgo1 Ranbp2 Bub1b Kif2a Frs3 Kif2b Kif2c Dync1li2 Dock3 Pmf1 Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Jag1 Ppp2r1b Ppp2r1a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Nuf2 Nup85 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Cenpo Cep97 Cenpn Cenpm Srgap1 Mis12 Srgap2 Nup133 Srgap3 Cenpl Arhgap39 Zwilch Cenpk Cenpi Cenph Cenpf Cenpe Dsp Pld2 Slc1a5 Dsg2 Dsg1a Tjp2 Uaca Prkca H2ac20 Ddx4 H2ac12 Cftr H2ac11 H2ac15 Klc1 Klc4 H3c7 Klc3 Klc2 H2ax Myh9 Myl12a Rac1 Hist1h2bp Vav1 H2aj Pik3r1 Pik3r2 Ccp110 Pak1 Pak3 Pak2 H2bc9 H2bc7 H2bc8 H2bc3 Rac2 S100a9 S100a8 H2ab2 H2bu2 Vcp Pik3ca Hist2h2aa1 Ywhag Kif5b Pdpk1 Men1 Lck H2bc14 Pard6a Rhoa Prkcz Arhgef18 Csk Steap3 H2bc21 H2bc26 Abl1 Arl13b Lman1 Mcf2l Rab7 Rhog Arhgdib Arhgdia Garre1 Scai Arhgef16 Shmt2 Arhgdig Arfgap3 Erbin Emd Lemd3 Iqgap2 Lbr Diaph3 Cdc42ep1 Depdc1b Vrk2 Vamp3 Epha2 Dock5 Arhgef26 Itsn1 Arhgap5 Myl12b Itgb1 Dock4 Arhgap1 Kalrn Myh11 Arhgap21 Ropn1 Letm1 Nf2 Prc1 Vangl1 Mcam Flna Ophn1 Stbd1 Ndufa5 Tpm3 Pld1 Dock1 Dock2 Mylk Vapb Elmo2 Myl6 Stx5 Capzb Arhgap32 Gja1 Ykt6 Pak4 Prex1 Arhgap35 Cct6a Trio Mcf2 Esyt1 Tuba1b Plekhg3 Mtmr1 Mpp7 Ktn1 Ankle2 Muc13 Cyfip1 Tmpo Cct2 Kdm1a Ppp1cb Actb Ptk2 Cct7 Pfn1 Sptan1 Pfn2 Abl2 Nck2 Nck1 Sptbn1 Evl Rnd3 Ckb Sos2 Sema4f Nisch Aaas Kctd13 Tnfaip1 Pak6 Ckap4 Myo9b Pak5 Sfn Hsp90aa1 Rhou Ptk2b Wdr91 Usp9x Osbpl11 Wdr81 Arhgap4 Arap1 Arhgap9 Arhgap8 Fam91a1 Gmip Cltc Baiap2l2 Golga3 Vma22 Def6 Fgd5 Gopc Lrrc1 Ralgapa1 Wdr11 Arfgap2 Akap12 Tex2 Mospd2 Arhgap12 Arhgap19 Arhgap18 Efhd2 Arhgap22 Arhgap20 Arhgap25 Arhgap24 Arhgap23 Arhgap29 Arhgap28 Zap70 Whamm Arhgap33 Arhgap31 Sh3pxd2a Arhgap30 Dock11 Plekhg6 Plekhg4 Plekhg1 Mtr Ralbp1 Arhgap40 Arhgap44 Arhgap45 Filip1 Hint2 Ankfy1 Faf2 Rhoh Rhof Rhod Rhov Diaph2 Fam13b Shkbp1 Pik3c3 Arhgap11a Emc3 Farp1 Pin1 Kctd3 Cdc42ep2 Cdc42ep5 Cdc42ep3 Cdc42ep4 Syde2 Dnmbp Nsfl1c Rhpn1 Ccdc187 Acbd5 Basp1 Pik3r4 Maco1 Ddrgk1 Ddx39b Spata13 Peak1 Gfod1 Srrm1 Rnd2 Dock6 Als2 Srf Bltp3b Armcx3 Add3 Tor1aip1 Fmnl2 Fmnl1 Cdc42se2 Tmem87a Sh3bp1 Prkcd Zfp512b Prag1 Sh3rf1 Cfl1 Itsn2 Scfd1 Picalm Trip10 Cttn Prkcb Grb7 Vangl2 Aldh3a2 Epsti1 Stip1 Rnd1 Wdr6 Rras2 Stmn2 Kif14 Ccdc88a Tmem59 Fam83b Ubxn11 Plxna1 Fam135a Cpd Dlg5 Ankrd26 Pkp4 Kdm4c Ywhah Ar Ywhaz Rhob Anln Arhgef17 Slk Arhgef11 Arhgef10 Cavin1 Iqgap3 Diaph1 Daam1 Akap13 Cit Cav1 Arhgef25 Arhgef28 Sowahc Stom Pkn3 Arhgef3 Arhgef2 Arhgef1 Pcdh7 Ect2 Vav3 Myo9a Rtkn Iqgap1 Actc1 Jup Rhpn2 Stk10 Net1 Arhgef10l Stard8 Vav2 Dlc1 Stard13 Pkn2 Pkn1 Tiam2 Rhoc Plxnb1 Arhgef15 Map3k11 Arhgef19 Ngef Plk1 Dbn1 Spen Twf1 Pde5a Msi2 Arhgef7 Tmod3 Myo6 Arhgef6 Txnl1 Phip Arhgef4 Gna13 Rbmx Fgd2 Actg1 Fgd1 Cops4 Fgd4 Tra2b Cops2 Fgd3 Stk38 Hsp90ab1 Arhgef39 Cpsf7 Arhgef40 Hnrnpc Stam2 Plekhg5 Actn1 Src Plekhg2 Cdc37 Rhobtb2 Rock2 Stam Ctnnb1 Rhobtb1 Rock1 Myh14 Vim Rnf20 Myh10 Hgs Hmox2 Cdh1 Limk1 Limk2 Mapk1 Mapk3 Ywhab Ncf1 Ncf2 Ncf4 Atp6ap1 Brk1 Ocrl Mapk14 Swap70 Amigo2 Noxa1 Frs2 Rac3 Tfrc Git1 Baiap2 Kidins220 Bcap31 Arhgap15 Arhgap17 Nckap1l Fermt2 Bcr Arhgap6 Arap3 Lamtor1 Arap2 Rapgef1 Baiap2l1 Sos1 Arhgap26 Syde1 Abr Mapk11 Nckap1 Slitrk5 Slitrk3 Nhs Git2 Wasf2 Wasf1 Noxo1 Dock10 Racgap1 Taok3 Snap23 Cyba Abi2 Abi1 Cybb Nox3 Arhgap42 Nox1 C1qbp Dbt Ncoa2 Xpo1 Arhgap10 Pgrmc2 Ctnna1 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9034013 NTF3 activates NTRK3 signaling Ntrk3 Ntf3 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis Angptl3 Nr1h2 Scd1 Nr1h3 Rxrb Nrip1 Fasn Rxra SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Alox12 ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway Tlr4 Tapbp Sec61b Fgb Fga Fgg Psma4 Ikbkb Psma3 Psma6 Psma5 Psma2 S100a9 Psma1 S100a8 Ikbkg Psmd12 Psmd11 Calr Tlr1 Cd14 Psmd14 Btk Tlr6 Psmd13 Tlr2 Sec22b Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 B2m H2-Q10 Vamp8 Psma7 Psmc6 Psmc5 Psmc2 Psme2 Psmc1 Psme1 Psmc4 Psmc3 Ubc Psmb10 Psmd7 Psmd6 Psmd8 Psmd3 Psmb9 Psmd2 Psmb8 Psmd1 Adrm1 Sem1 Chuk S100a1 H2-M5 Cd36 H2-M3 Tirap Myd88 Snap23 H2-Q1 Vamp3 Pdia3 Ly96 Sec61a2 Sec61a1 Tap2 Tap1 Stx4 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 96%9034015 Signaling by NTRK3 (TRKC) Nelfb Irs1 Src Nras Plcg1 Sos1 Hras Ntf3 Ptprs Pik3ca Ptpro Ntrk3 Bax Pik3r1 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432040 Vasopressin regulates renal water homeostasis via Aquaporins Prkaca Prkar2b Gng10 Gng3 Rab11a Gng2 Rab11fip2 Prkar1a Gng4 Gng7 Gng8 Prkacb Avpr2 Prkar2a Avp Gngt1 Gngt2 Adcy3 Adcy4 Adcy1 Aqp4 Adcy2 Aqp3 Adcy7 Aqp2 Adcy8 Adcy5 Adcy6 Adcy9 Gnb2 Myo5b Aqp1 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Prkar1b Gng13 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants Flt3 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes Hspa5 Hsp90b1 Nfyb Nfya Calr Ddit3 Nfyc Atf6 Atf4 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Ywhae Psmd14 Chek2 Psmd13 Cdc25c Psmb5 Psmb4 Psmb7 Cdc25a Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Gtse1 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Ube2n Ube2v2 Trp53 Pias4 Ywhah Kat5 Exo1 Nbn Rfc5 Ywhaz Rfc3 Rfc4 Mdc1 Orc5 Orc4 Rfc2 Orc6 Orc1 Hus1 Mcm8 Atrip Orc3 Orc2 Brip1 Dna2 H2ax Blm Chek1 Rad9a Hist1h2bp Bard1 Rad9b Sfn Top3a Wrn Mre11a Herc2 Rad50 Rpa1 Topbp1 Rpa2 Rad17 Rbbp8 Brca1 H2bc9 Rpa3 H2bc7 H2bc8 Rad1 Cdc7 Atm H2bc3 H3c8 Cdk1 Pkmyt1 H2bu2 Mcm7 Cdk2 Mcm3 Mcm4 Ccna1 Mcm5 Ccna2 Mcm6 Cdc45 Mcm2 Ywhab Wee1 Ywhag Dbf4 Mcm10 H2bc14 Cdc6 H2bc21 H2bc26 Clspn Trp53bp1 Abraxas1 Brcc3 Rnf168 Nsd2 Babam1 Babam2 Uimc1 Ccnb2 MITOPHAGY%REACTOME DATABASE ID RELEASE 96%5205647 Mitophagy Ube2v1 Map1lc3a Fundc1 Atg5 Atg12 Atg9a Tbk1 Tomm22 Prkn Sqstm1 Optn Ube2l3 Tomm40 Mfn1 Mfn2 Csnk2a2 Ulk1 Mterf3 Vdac2 Ube2d3 Pink1 Tomm6 Ubc Vdac3 Tomm7 Tomm70 Map1lc3b Vdac1 Ube2n Csnk2b FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling Nfatc1 Nfatc3 Nfatc2 Rasgrp1 Ppp3r1 Ppp3ca Ppp3cb Psma4 Ikbkb Jun Psma3 Plcg2 Psma6 Txk Psma5 Psma2 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Btk Psmd14 Psmd13 Nfkb1 Skp1 Malt1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Card11 Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Bcl10 Psmd7 Psmd6 Syk Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Cul1 Traf6 Ube2n Prkcq Chuk Rasgrp4 Rasgrp2 Cdc34 Ube2v1 Tab3 Tab2 Tab1 Lyn Ahcyl1 Rac1 Fos Vav1 Pik3r1 Pik3r2 Vav3 Pak1 Itpr3 Itpr2 Vav2 Itpr1 Mapk9 Pak2 Mapk8 Grap2 Fcer1a Ms4a2 Ube2d1 Tec Pik3cb Itk Pik3ca Lcp2 Mapk1 Lat2 Mapk3 Pdpk1 Map2k7 Fcer1g Map2k4 Mapk10 Nras Plcg1 Sos1 Hras Gab2 Fyn Map3k1 G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint Ccna1 Ccna2 Wee1 Cdk1 Ccnb2 Pkmyt1 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade Tlr4 App Ikbkb Jun Peli1 Ikbkg Map3k7 Traf2 Cd14 Btk Nfkb1 Socs1 Skp1 Fbxw11 Rela Btrc Casp8 Ubc Nfkbib Irak1 Nfkbia Cul1 Traf6 Ube2n Chuk Ube2v1 Trp53 Tab3 Sigirr Tab2 Tab1 S100a1 Irak3 Cd36 Tirap Rps6ka1 Tifa Alpk1 Nfkb2 Fos Fgb Fga Mapk9 Mapk7 Fgg Mapk8 S100a9 Elk1 S100a8 Tlr1 Tlr6 Tlr2 Map3k8 Mapk1 Mapk3 Rps6ka3 Mapkapk3 Rps6ka2 Mapkapk2 Map2k7 Mapk14 Map2k6 Ppp2cb Ppp2ca Map2k4 Map2k3 Mapk10 Map2k1 Mapk11 Ripk2 Myd88 Rps6ka5 Nkiras1 Atf2 Nkiras2 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Ppp2r1a Peli2 Peli3 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Usp18 Ppp2r5d Ly96 Mef2c STABILIZATION OF P53%REACTOME%R-HSA-69541.7 Stabilization of p53 Trp53 Psma4 Atm Psma3 Psma6 Psma5 Psma2 Psma1 Cdkn2a Psmd12 Psmd11 Phf20 Psmd14 Chek2 Psmd13 Cop1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Mdm2 Ubc Mdm4 Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 96%6806667 Metabolism of fat-soluble vitamins Pnlip Ubiad1 Apoe Lrat Vkorc1 Apom Lrp10 Gpc1 Lrp12 Retsat Gpc3 Gpc2 Hspg2 Gpc5 Sdc4 Sdc3 Gpc4 Sdc2 Gpc6 Lrp1 Rdh11 Lrp2 Akr1c18 Bco2 Bco1 Ttr Apoa2 Ldlr Vkorc1l1 Apoa4 Rbp4 Sdc1 Lpl Rbp2 Gpihbp1 Rbp1 Apoc2 Agrn Plb1 Akr1c21 Akr1b10 Ttpa Apoc3 Apoa1 Akr1c6 Clps Apob SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 96%1227986 Signaling by ERBB2 Nrg3 Memo1 Nras Gab1 Ptpn18 Plcg1 Prkca Ptpn12 Sos1 Hras Rhoa Fyn Egf Akt3 Ereg Akt2 Hbegf Akt1 Btc Cul5 Prkce Yes1 Src Cdc37 Erbin Grb7 Prkcd Nrg1 Rnf41 Usp8 Stub1 Matk Ubc Egfr Erbb2 Pik3ca Diaph1 Ptk6 Shc1 Hsp90aa1 Pik3r1 Nrg2 Nrg4 MRNA POLYADENYLATION%REACTOME DATABASE ID RELEASE 96%9770562 mRNA Polyadenylation Dnajc8 Rbm17 Ddx46 Ddx42 Dhx9 Ppp1ca Ppp1cb Ddx5 Sympk Cstf1 Papola Clp1 Nudt21 Cpsf1 Xrn2 Cstf2 Cpsf2 Hnrnpu Cstf3 Cpsf3 Cstf2t Wdr33 Ubc Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 Ybx1 Phf5a Hnrnpa2b1 Puf60 Smndc1 Pcbp2 Pcbp1 Hnrnpr Cpsf4 Papolg Sugp1 Hnrnpd Hnrnpf Hnrnpk Ccar1 Hnrnpl Prpf40a Hnrnpm Snrnp70 Htatsf1 Ppp1r8 Snrpa Rbmx Snrpc Rbm25 Hnrnph2 Srsf10 Tra2b Hnrnph1 Tut1 Ppp1r10 Tcerg1 Cpsf7 Rbm39 Hnrnpc Rbm5 Pabpn1 Fip1l1 U2surp Snrpb2 Snrpa1 Ptbp1 Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Sf3b5 Srsf1 Sf3b6 Srrt Srsf9 Cdc40 Snrpn Srsf7 Srsf6 Cherp Srsf3 Fus Srsf2 Srsf11 Hnrnpa3 Hnrnpa1 U2af1l4 Snrpb Rbm10 Snrpd2 Snrpd1 Dhx15 Snrpd3 Srrm2 Ncbp2 Ncbp1 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) Gusb LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME%R-HSA-9022538.2 Loss of MECP2 binding ability to 5mC-DNA Sin3a Hdac1 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9968551 Regulation of GBP-mediated host defense Sfn Casp1 Pim1 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis Tgfb1 Slc25a5 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding Ppp2cb Ppp2ca Gsk3b Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation Camkmt Etfbkmt Etfb Vcp Mettl21A Mettl22 Prmt3 Eef2kmt Hspa8 Kin Eef1akmt2 Eef1akmt1 Eef2 Vcpkmt ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway Adcy9 Gnal Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Txnrd1 Papss2 Papss1 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis Dhrs7b Agps Gnpat MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9022707 MECP2 regulates transcription factors Rbfox1 Pparg Mef2c PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling Pde3b Akt2 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844455 The NLRP1 inflammasome Bcl2 Nlrp1a Bcl2l1 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 96%68949 Orc1 removal from chromatin Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Skp2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Mcm7 Psmc1 Psmc4 Psmc3 Mcm3 Ubc Cdk2 Mcm4 Ccna1 Mcm5 Psmd7 Ccna2 Mcm6 Psmd6 Mcm2 Psmd8 Cdt1 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Cdc6 Orc5 Orc4 Orc6 Orc1 Mcm8 Orc3 Orc2 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance Tuba1a Esrra Sod2 Cct3 Cct2 Ywhae Tcp1 Tuba4a Cct8 Chchd6 Samm50 Cct5 Cct4 Smo Chchd3 ATP6 Immt Atp5f1d Atp5pb Atp5f1c Prkar2b Atp5pf Apool Mtx1 Mtx2 Tmem11 Atp5mc3 Apoo Tubb4b Tubb4a Atp5mf Hspa9 Atp5me Dmac2l Atp5f1b Atp5f1a Dnajc11 Atp5mk Micos10 Micos13 Hsp90aa1 Prkaca Glud1 Gabpa Kif17 Pprc1 Sirt5 Nrf1 Polg2 Cpap Clasp1 Pafah1b1 Twnk Polrmt Ssbp1 Hdac6 Rho Mapre1 Dynll1 Dynll2 Ppp2r1a Dync1h1 Tfb1m Dync1i2 Ckap5 Akap9 B9d2 Nedd1 Cc2d2a Tmem67 Actr1a Dynlrb2 Dynlrb1 Cep97 Cys1 Dctn2 Dctn3 Ift70b Rpgrip1l Rab11a Dynlt2a1 Ift88 Ift81 Exoc3 Exoc4 Exoc5 Cluap1 Exoc6 Exoc1 Acss2 Hcfc1 Exoc2 Dynlt2b Sstr3 Exoc7 Exoc8 Ift80 Pcnt Traf3ip1 Arl6 Fbf1 Arl3 Cep250 Sdccag8 Cep78 Ppargc1b Ift140 Dynlt5 Cep76 Iqcb1 Cep72 Cep70 Bbs2 Bbs1 Tubb5 Plk4 Ift22 Kif3a Kif3b Ift27 Kif3c Ift25 Ahi1 Cep89 Cep135 Nphp4 Sirt3 Nphp3 Cep131 Cep83 Lztfl1 Mks1 Nphp1 Rab11fip3 Ift52 Arf4 Ppara Mkks Unc119b Haus7 Haus8 Alas1 Ttc21b Cdk5rap2 C2cd3 Rxra Ift56 Prkaa2 Pkd2 Pkd1 Ift57 Mark4 Cep57 Pcm1 Rp2 Asap1 Ssna1 Bbs9 Mchr1 Bbs7 Tubg1 Bbs5 Camk4 Ift122 Bbs4 Ofd1 Bbs10 Ift43 Bbs12 Septin2 Cep162 Ift46 Cep63 Rab3ip Cep152 Haus3 Kif24 Haus4 Haus5 Haus6 Sfi1 Ttbk2 Csnk1d Haus1 Wdr35 Haus2 Ift74 Tctn3 Tctn1 Tctn2 Cnga4 Kifap3 Cnga2 Dync2h1 Ift70a1 Cep164 B9d1 Ccp110 Atat1 Alms1 Gbf1 Cetn2 Tnpo1 Trip11 Rab8a Dync2li1 Dync2i1 Dync2i2 Ift172 Ttc8 Cep43 Wdr19 Cep41 Plk1 Sirt4 Sclt1 Ninl Cdk1 Nek2 Prkag3 Prkag1 Prkag2 Mapk12 Ywhag Mapk14 Mterf1b Csnk1e Mapk11 Tfb2m Tfam Inpp5e Ncor1 Arl13b Atf2 Pde6d Helz2 Carm1 Prkab2 Prkab1 Tbl1x Mef2d Crtc3 Hdac3 Crtc2 Ncoa2 Ncoa1 Tbl1xr1 Smarcd3 Crtc1 Ncoa6 Med1 Nr1d1 Ppargc1a Crebbp Mef2c Chd9 Idh2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Rnmt Ercc3 Cdk7 Rngtt Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%446728 Cell junction organization Sp1 Arhgap32 Tyk2 Banp Birc2 Angptl4 Ang Xiap Kdm1a Zfp217 Ank3 Pomt1 Pomt2 Vasp Tgif2 Klf9 Strap Foxj2 Foxp2 Twist2 Twist1 Cdh4 Cdh15 Nectin1 Nectin2 Nectin3 Nectin4 Pard6b Il6 Cldn23 Cldn6 Cldn3 Cldn4 Cldn9 Canx Cldn20 Cldn22 Cldn7 Cldn8 Pard6g Cldn12 Rb1 Cldn15 Arid1a Cldn14 Cldn11 Cldn10 Cldn1 Dnm2 Cldn17 Kmt5a Mdm2 Zmym2 Cldn16 Cldn19 Cldn18 Cadm3 Cadm2 Cadm1 Cldn2 Mtbp Rack1 Foxq1 Il6st Wt1 Zc3h12a Farp2 Cdh9 Cdh7 Cdh6 Cdh5 Cdh3 Tle1 Sdk1 Pcsk7 Tiam1 Sdk2 Cdh19 Cdh17 Pkm Cdh13 Foxa2 Cdh12 Cdh10 Zbtb33 Hdac2 Mphosph8 Mcrip1 Prkci Itga6 Itgb4 Smarca4 Il6ra Zeb2 Ctsb Ctss Hace1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Lamb3 Psmd14 Lama3 Psmd13 Nfkb1 Psmb5 Lamc2 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rela Psma7 Psmc6 Pip5k1c Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Ganab Cdh2 Mogs Pxn Rnf19b H2ac20 Zeb1 Tcf3 Hdac1 Plec Myc Prkcsh Traf7 Rpn2 Rpn1 Cd151 Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 Sox10 H3c7 Ezh2 H2ax Snai2 Csnk2a2 Suz12 Rac1 Hist1h2bp Jak1 Cldn5 H2aj Rsu1 Jup Tesk1 Jak2 Parvb Parva Vav2 Lims2 H2bc9 H2bc7 Flnc H2bc8 Fblim1 Ilk H2bc3 Vcl Stat3 Tmem258 Arhgef6 Arhgef4 H2ab2 Mycn Sec11c Sec11a H2bu2 Actn1 Stt3a Src Ctnnb1 Eps15 Cbll1 Ostc Tcf12 Ctnnd1 Cdh1 Crb3 Patj Pals1 Mapk1 Mapk3 Hist2h2aa1 Furin Ctbp1 Ctbp2 Pcsk6 Dad1 Ddost Csnk2b Eed Fermt2 H2bc14 Pard6a Pard3 F11r Tfap2a H2bc21 Tnrc6c H2bc26 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Col17a1 Spcs3 Spcs1 Hoxc8 Spcs2 Itgb1 Heyl Cdh8 Adam19 Adam33 Cdh24 Elmo1 Ctnna1 Snai1 Klf4 Prdm8 Ilf3 Flna Foxf1 Bhlhe22 Cdh11 Sirt1 Dock1 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism Ube2i Lrp2 Cyp27b1 Lgmn Vdr Ldlrap1 Gc Cyp24a1 Cyp2r1 Pias4 Cubn NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME%R-HSA-9636003.2 NEIL3-mediated resolution of ICLs Neil3 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions Tyrobp Ptk2 Cd47 Skap2 Ptk2b Ptpn6 Sirpa Sirpb1b Fyb1 Ptpn11 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME%R-HSA-8932505.1 DAG1 core M3 glycosylations B3galnt2 Pomgnt2 Pomt1 Dag1 Pomk Pomt2 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay Lsm5 Dcp1a Cnot6l Dcp1b Lsm1 Edc3 Edc4 Xrn1 Lsm6 Lsm7 Patl1 Ddx6 Skic2 Skic8 Cnot3 Cnot2 Cnot1 Cnot7 Cnot6 Eif4g1 Cnot4 Cnot9 Cnot8 Cnot11 Pabpc1 Tut7 Tut4 Paip1 Eif4b Pan2 Eif4e Pan3 Eif4a2 Skic3 Eif4a1 Dcps Hbs1l Nt5c3b Cnot10 Tnks1bp1 Eif4a3 Exosc9 Exosc8 Exosc5 Dis3 Exosc4 Exosc7 Exosc6 Parn Exosc1 Exosc3 Exosc2 Dcp2 Lsm2 Lsm3 Lsm4 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-HSA-420092.5 Glucagon-type ligand receptors Ghrhr Gng10 Gcgr Glp2r Vipr2 Vipr1 Gng3 Gng2 Gng4 Gng7 Ghrh Gng8 Gngt1 Gngt2 Sct Adcyap1 Gcg Adcyap1r1 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gipr Gng11 Gip Vip Gng12 Gng13 Glp1r DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 96%9734195 Defective APRT disrupts adenine salvage Aprt DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding Nthl1 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 96%4085023 Defective GFPT1 causes CMSTA1 Gfpt1 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 96%5603029 IkBA variant leads to EDA-ID Nfkb2 Ikbkg Rela Nfkb1 Nfkbia Ikbkb Chuk IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 96%9709570 Impaired BRCA2 binding to RAD51 Topbp1 Rpa2 Rad17 Rbbp8 Brca2 Brca1 Rpa3 Rad1 Atm Kat5 Exo1 Nbn Rfc5 Rfc3 Rfc4 Rfc2 Hus1 Atrip Brip1 Dna2 Blm Rad9a Bard1 Rad9b Top3a Wrn Mre11a Sem1 Rad51 Rad50 Rpa1 INHIBITION OF PKR%REACTOME%R-HSA-169131.8 Inhibition of PKR Eif2ak2 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764725 Negative Regulation of CDH1 Gene Transcription H2bc9 H2bc7 H2bc8 H2bc3 H2ab2 Kdm1a H2bu2 Zfp217 Tcf12 Kmt5a Zmym2 Mapk1 Hist2h2aa1 Mapk3 Ctbp1 Ctbp2 Foxq1 Wt1 Eed Tle1 Tgif2 Pkm H2bc14 H2ac20 Zeb1 Tcf3 Zbtb33 Hdac2 Hdac1 Mphosph8 Mcrip1 H2bc21 H2bc26 Rbbp4 Rbbp7 Smarca4 H2ac12 H2ac11 H2ac15 H3c7 Twist2 Ezh2 H2ax Zeb2 Twist1 Snai2 Suz12 Hist1h2bp H2aj Snai1 Sirt1 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163767.6 PP2A-mediated dephosphorylation of key metabolic factors Ppp2cb Ppp2ca Mlxipl Ppp2r5d Pfkfb1 Ppp2r1b Ppp2r1a RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 96%9665246 Resistance of ERBB2 KD mutants to neratinib Erbb2 Cdc37 Erbin Hsp90aa1 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression H2bc9 H2bc7 H2bc8 H2bc3 Gatad2a Gatad2b Ehmt2 H2ab2 Polr1c Mbd3 Actb Polr1d H2bu2 Mta1 Mta3 Ttf1 Polr1b Polr1a Polr1g Kat2b Polr1e Polr1h Kat2a Taf1d Polr2h Hist2h2aa1 Taf1a Polr2e Taf1c Polr2f Taf1b Polr2k Cbx3 Mybbp1a Ddx21 Gsk3b Sf3b1 H2bc14 H2ac20 Hdac2 Hdac1 H2bc21 H2bc26 Rbbp4 Rbbp7 Ep300 Dek Chd3 Baz1b Chd4 H2ac12 H2ac11 Ercc6 H2ac15 Tbp Smarca5 H3c7 H2ax Mta2 Hist1h2bp H2aj DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9630221 Defective NTHL1 substrate processing Nthl1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 96%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Elmo2 Arhgap35 Rasa1 Pxn Nras Crk Hras Rhoa Ptk6 Bcar1 Rac1 Elmo1 Dock1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 96%417957 P2Y receptors P2ry10 Ppan P2ry13 P2ry6 Gpr17 P2ry12 P2ry2 P2ry14 P2ry1 Lpar4 Lpar6 P2ry4 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis Sord Akr1b1 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%425407 SLC-mediated transmembrane transport Slc17a8 Fgf21 Slc44a3 Slc5a7 Slc44a4 Slc44a5 Slc10a6 Slc44a1 Slc44a2 Arl2 Slco4c1 Slc22a5 Slc2a13 Slc5a11 Slc5a3 Slco2b1 Slc27a1 Slc39a3 Slc16a2 Slc8b1 Slc39a2 Slc39a1 Slc39a8 Slc39a7 Slc39a6 Slc35d1 Slc39a5 Slc2a12 Slc28a1 Slco4a1 Slc17a1 Slc29a4 Slc30a10 Slc25a1 Slc26a6 Slc26a9 Slc26a7 Slc12a1 Slc12a4 Slc12a5 Slc27a6 Slc12a2 Slc35b4 Slc12a3 Slc35d2 Slc5a10 Slc12a6 Slc5a12 Slc12a7 Slc2a6 Slc2a7 Slc39a14 Slc39a10 Slc25a5 Slco1c1 Ahcyl2 Slc25a4 Slc13a5 Slc13a3 Slc26a11 Slc13a4 Slc13a1 Slc13a2 Slc4a10 Slc4a7 Sri Slc6a11 Slc35a1 Slc6a13 Slc4a2 Slc4a3 Slc22a2 Slc4a5 Slc22a1 Slc4a8 Slc4a9 Slc6a1 Slc6a4 Slc45a3 Slc22a6 Slc8a1 Slc8a2 Lcn12 Slc2a4 Slc11a1 Slc8a3 Slc5a9 Arl2bp Slc31a1 Slc16a3 Slc20a1 Emb Slc32a1 Slc16a8 Slc5a4a Slc16a7 Slc41a2 Slc41a1 Slc30a3 Slc30a2 Slc35c1 Slc30a1 Slc50a1 Slc25a10 Slc17a5 Slc5a6 Pdzd11 Slc6a7 Slc6a9 Slc17a6 Slc26a2 Slc26a1 Slc15a1 Ctns Slc15a3 Slc15a4 Slc5a8 Slc2a3 Slc24a1 Slc35b3 Slc35b2 Slc2a1 Slc2a8 Slc35a3 Slc43a1 Slc43a2 Slc7a11 Slc7a10 Slc1a1 Slc25a29 Slc3a1 Avp Slc38a5 Slc1a3 Slc38a4 Slc1a2 Slc1a5 Slc38a3 Slc38a2 Slc36a4 Slc1a4 Slc25a18 Slc3a2 Slc25a11 Slc1a7 Slc25a22 Slc1a6 Slc7a3 Slc7a1 Slc6a6 Slc6a19 Slc7a6 Slc7a7 Slc7a5 Slc6a15 Slc38a1 Slc2a9 Slc6a14 Slc36a2 Slc7a8 Slc36a1 Slc7a9 Slc6a12 Slc6a20a Apod Slco1a4 Slc22a8 Bsg Slc4a4 Slc33a1 Slc22a15 Slc47a1 Slc14a2 Slc26a4 Slc25a26 Slc26a3 Slc22a4 Slco2a1 Slc5a5 Slc22a16 Slc14a1 Slc27a4 Slc24a3 Slc39a4 Slc24a2 Slc6a2 Slc6a5 Slc2a10 Slc16a1 Slc35a2 Slco1b2 Slc24a5 Slc20a2 Slc24a4 Slc22a12 Slc29a3 Slc29a2 Slc28a3 Slc28a2 Slc29a1 Slc40a1 Cp Slc4a1 Slc11a2 Slc30a5 Slc30a8 Heph Slc9a4 Slc9a5 Slc9a2 Slc9a3 Slc9a8 Slc9a9 Slc9a6 Slc9a7 Slc34a1 Slc9a1 Slc34a3 Slc34a2 Slc2a2 Slc5a1 Slc22a3 Slc6a3 Slc22a18 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 96%5358752 CTNNB1 T41 mutants aren't phosphorylated Ppp2cb Ppp2ca Gsk3b Ctnnb1 Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 SCN4%REACTOME%R-HSA-3282872.4 SCN4 G6pc3 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559585 Oncogene Induced Senescence Sp1 Trp53 Ets1 Ets2 Cdkn2a Cdkn2b Tnrc6c Cdkn2c Erf Tnrc6a Tnrc6b Mov10 Ago4 Ago3 Id1 Tfdp2 Ago1 Tfdp1 Rb1 Cdk6 Cdk4 Mdm2 Ubc E2f1 Mdm4 E2f2 E2f3 Mapk1 Mapk3 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 96%9821993 Replacement of protamines by nucleosomes in the male pronucleus H2bu2 Srpk1 Prm2 Npm2 H2bc14 H2bc9 H2ax H1.8 H2bc7 H2bc8 H2bc3 H2bc21 Hist1h2bp H2bc26 Hira Mettl23 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation Pde1b Pde1c Pde1a NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9031628 NGF-stimulated transcription Fosb Egr2 Elk1 Nab1 Nab2 Cdk5r1 Junb Trib1 Arc Tph1 Cdk5 Atf2 Jund Id2 Id3 Fosl1 Egr3 Sgk1 Egr4 Srf Ep300 Lyl1 Egr1 Ascl1 Mef2d Rrad Chd4 Id4 Cdk5r2 Sh3gl3 F3 Vgf Id1 Rest Tcf12 Dnm2 Fos C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine Adar Adarb1 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 96%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Pomt1 Dag1 Pomt2 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways Upk1a Sfpq Epcam Gucy2c EG433182 Hbegf Tlr2 Hsp90ab1 Stam2 Sh3gl3 Src Sh3kbp1 Coro1a B2m Stam Ctsg Ctnnb1 Vps33b Eps15 Cbll1 Rab5a Cbl Mrc1 Hgs Ltf Dusp16 Casp4 Ctnnd1 Cdh1 Gbp2 Sh3gl1 Gbp3 Sh3gl2 Met Ubc Pdcd6ip Gbp9 Mapk1 Mapk3 Furin Map2k7 Gsk3a Pgk1 Map2k4 Map2k2 Map2k1 Trim27 Atp6v1h Txnrd1 Stx1b Sv2c Syt2 Snap25 Sv2b Kpna1 Syt1 Eef2 Sv2a Rab7 Vamp1 Vamp2 Stx1a Nos2 Nherf4 Rnf213 Hba-a1 Hbbt1 Kpnb1 Hsp90aa1 Cd9 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 96%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Ctsk Ctsl Socs3 Cbfb Socs4 Serpinb13 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8931838 DAG1 glycosylations Slc35a4 B3galnt2 Large1 Chst10 B4gat1 Fktn Slc35a1 Rxylt1 Mgat5b Pomgnt1 Fkrp Large2 Pomgnt2 Pomt1 Crppa Dag1 Pomk Pomt2 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME%R-HSA-9005891.5 Loss of function of MECP2 in Rett syndrome Prkaca Ncor2 Sin3a Hdac3 Ncor1 Gps2 Tbl1xr1 Camk4 Hdac1 Tbl1x ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 96%1482925 Acyl chain remodelling of PG Pla2g2e Pla2g2d Pla2g4a Crls1 Pla2g2f Pla2g4d Lpcat4 Pla2g12a Pla2g5 Pla2g1b Pla2r1 Pla2g4f Lpgat1 Pla2g10 Lpcat1 Pla2g3 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function Rdh5 Rlbp1 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance Nhp2 Rpa2 Rtel1 Gar1 H2bc9 Rpa3 H2bc7 H2bc8 Tinf2 H2bc3 Nop10 Shq1 Dscc1 Ruvbl2 Ppp6r3 Pif1 Ruvbl1 Chtf18 H2ab2 Ctc1 Chtf8 H3c8 Stn1 Ten1 Ppp6c H2bu2 Atrx Acd Terf2ip Polr2c Cdk2 Polr2d Ccna1 Polr2a Ccna2 Polr2b Terf2 Polr2g Terf1 Polr2h Daxx Hist2h2aa1 Polr2e Polr2f Polr2k Fen1 Polr2i Polr2j Pot1 Wrap53 Ankrd28 H2bc14 H2ac20 Tert H2bc21 H2bc26 Lig1 Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 H2ac12 Prim2 H2ac11 Rfc1 Prim1 Rfc2 Pold4 Pola2 Pold3 Pola1 H2ac15 H2ax Dna2 Blm Hist1h2bp H2aj Wrn Dkc1 Rpa1 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME%R-HSA-167246.4 Tat-mediated elongation of the HIV-1 transcript Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Ell Nelfa Nelfb Nelfe Ctdp1 Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Polr2b Supt4h1a Polr2g Tcea1 Polr2h Nelfcd Polr2e Supt16 Polr2f Cdk9 Polr2k Mnat1 Ssrp1 Polr2i Ccnt1 Polr2j Gtf2h2 Eloa Gtf2h1 Gtf2f2 Gtf2h4 Eloc Gtf2f1 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) Kcnk13 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%198693 AKT phosphorylates targets in the nucleus Akt3 Akt2 Akt1 Rps6kb2 Foxo4 Foxo3 Nr4a1 Foxo1 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones Hspa5 Hsp90b1 Nfyb Nfya Calr Ddit3 Nfyc Atf6 Mbtps1 Mbtps2 Atf4 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Psma4 Rps21 Psma3 Abce1 Psma6 Rpl39l Pelo Psma5 Rps15a Psma2 Psma1 Psmd12 Psmd11 Psmd14 Rps27l Psmd13 Rplp2 Rpl22l1 Rplp1 Ube2d1 Rpl13a Rchy1 Psmb5 Rpl18a Psmb4 Psmb7 Rpl17 Psmb6 Rpl18 Psmb1 Rpl19 Ltn1 Psmb3 Rpl10l Psmb2 Rpl11 Rps3 Rps4x Vcp Rbx1 Psma7 Psmc6 Psmc5 Znf598 Psmc2 Ankzf1 Psmc1 Klhdc10 Psmc4 Ube2d3 Psmc3 Tcf25 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul2 Rps27 Ufd1 Nploc4 Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Ascc3 Ascc2 Rps11 Rpl7 Rpl32 Rps9 Eloc Rps7 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9953170 GBP-mediated host defense Gbp5 Furin Sfn Pggt1b Fnta Fntb Actg1 Casp1 Gbp2 Actb Gbp3 Pim1 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-HSA-6785807.8 Interleukin-4 and Interleukin-13 signaling Stat6 Mmp9 Anxa1 Jak3 Tyk2 Pim1 Il18 Foxo1 Fn1 Lama5 Timp1 S1pr1 Fasl Socs1 Foxo3 Pou2f1 Vegfa Muc1 Il1a Il1b Oprm1 Socs5 Trp53 Rora Il4 Il13 Zeb1 Myc Maoa Cd36 Akt1 Il2rg Hif1a Nos2 Pomc Fscn1 Ndn Il10 Mcl1 Mmp1a Twist1 Il4ra Jak1 Fos Hsp90aa1 Pik3r1 Rhou Ccl11 Gata3 Jak2 Ccl12 Osm Ccl22 Batf Tgfb1 Il13ra1 Il13ra2 Stat3 Junb Stat1 Oprd1 Mmp3 Il6 Vim Ccnd1 Hspa8 Hgf Cdkn1a Alox15 Socs3 Itgax Itgam Rorc Itgb2 Il12b Fgf2 Il12a Tnf Tnfrsf1b Lif Fcer2a Irf4 Lcn2 Bcl2 Lbp Bcl2l1 Icam1 Bcl6 Cebpd Hmox1 Saa3 Il6ra Birc5 Sox2 Alox5 Itgb1 Ptgs2 Hsp90b1 Il17f Il17a Col1a2 Mmp2 Il23r Vcam1 F13a1 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME%R-HSA-190827.4 Transport of connexins along the secretory pathway Gja1 Gjb2 Gjb1 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%381753 Olfactory Signaling Pathway Or51a5 Or2z8 Or51d1 Or4x11 Or6a2 Or9g8 Or9g4 Or51b17 Or52e4 Or52e2 Or6b3 Or6b2 Or6b1 Or13c7d Or2t1 Or9a4 Or51f2 Or52h1 Or10p1 Or5h19 Or5h17 Or5h18 Or2t6 Or1s2 Or51e2 Or51e1 Or2v2 Or52j3 Or4d10c Or5ak23 Or10j27 Or51g2 Or2w1 Or2w3 Adcy3 Or8b8 Or51g1 Or52i2 Or8b4 Or8b3 Or10q1 Or5h26 Or5h25 Or4f15 Or13j1 Or10g1b Or8b12i Or4c3 Or3a1 Or4d2 Or4d1 Or5b99 Or6c76 Or6c75 Or6c74 Or4d6 Or4d5 Or10c1 Or11h4 Or4n4b Or7c70 Or2a7 Lhx2 Or10h1b Or2a5 Or10h28 Or5m10 Or11h6 Or7a36 Or11g2 Or2b6 Or2c1 Or6k6 Or10ag2 Or5i1 Or6k2 Or9q2 Or9q1 Or8b12 Or10h5 Or6c6 Or8a1b Or6c3 Or5a1 Or5l14 Or5l13 Or10g3 Or7a41 Or5b3 Or9k2 Or4k15 Or8i2 Or10g9 Or5p80 Or10g7 Or10j5 Or11l3 Or5c1 Or5k16 Or8j3 Or6f1 Or52b2 Or52a20 Or2ag2 Or8k3 Gnb1 Or2ag1 Or8k1 Or52e8b Or52a5 Gng13 Or8g20 Or10g9b Or51s1 Or2h2 Or9i1b Or2h1 Or6p1 Or4l1 Or4b1d Or8u9 Or4m1 Or13a1 Or4a15 Or8u3 Or5ap2 Or5d43 Or5as1 Or5b107 Or2m13 Gnal Or52w1 Or4n5 Or5p6 Or2j3 Or56b1b Or4n4 Or4a47 Or13d1 Or7d11 Or5ar1 Or5b21 Or10ad1c Or51t4 Or2m12 Or13c3 Or1i2 Or2k2 Or6s1 Rtp2 Rtp1 Or5au1 Or4g7 Or1b1 Or2d2 Or5j3 Or13f5 Or4a68 Or6c1b Or5k8 Or2l13 Or5k1 Or11a4 Or8g51 Or6c65 Or14j1 Or1d2 Or2f2 Or2f1 Or6n2 Or6n1 Or6c68 Or13g1 Or1j19 Or5m8 Or5m9 Or5ac16 Or4k2 Or5m3 Or56a5 Or4k5 Or1e1 Or10a3 Or12d17 Ebf1 Or10a4 Or56a4 Or10a5 Or4k1 Or4a79 Or12d12 Or10a2 Ano2 Ldb1 Cnga4 Cnga2 Or5v1 Or6x1 Or1a1b Or52l1 Or1n1 Or1n2 Or6y1 Or51i2 Or2t44 Or51i1 Or52k2 Or8k16 Or7e178 Or2t45 Or10s1 Or13c25 Or2b11 Or52n4 Or52n5 Or52n2 Or2b2b Or10a3b Or10w1 Or2a25 Or4c106 Or2at4 Or1q1 Or52m1 Or51f1d Or10v1 Or4f58 Or4d10 Or4d11 Or2a12 Or7g19 Or2l5 Or1j4 Or5d18 Or4c29 Or1j1 Or5m10b Or5d16 Or5d14 Or14c46 Or52z13 Or51m1 Or10x1 Or4c15 Or4c11 Or4c12 Or4q3 Or4c10 Or3a1d Or3a1c Or51q1 Or56a3b Or1l8 Or5t9 Or1l4 Or7g34 Or4s2b Or7g33 Or5t5 Or8h10 Or5t17 Or52r1 Or10z1 Or5m11b Or2a57 Or5an1 Or5b12b Or2a56 Or1m1 Reep1 Or52d1 Or1e1c Or14a259 Or14a257 Or51b6 Or51b4 Or2l13b Or10k2 Or8d4 Or8d6 Or2y1 Or8d1 Or51a7 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog Psma4 Psma3 Psma6 Psma5 Psma2 Evc2 Rpgrip1l Psma1 Iqce Evc Gas8 Ift88 Psmd12 Efcab7 Psmd11 Psmd14 Psmd13 Smurf2 Skp1 Smurf1 Psmb5 Prkacb Hhip Psmb4 Boc Psmb7 Psmb6 Gas1 Cdon Psmb1 Psmb3 Psmb2 Notum Itch Btrc Adcy3 Rbx1 Adcy4 Psma7 Adcy1 Psmc6 Adcy2 Psmc5 Ihh Ift140 Adcy7 Psmc2 Adcy8 Psmc1 Adcy5 Psmc4 Adcy6 Psmc3 Ubc Shh Adcy9 Psmd7 Psmd6 Numb Psmd8 Kif3a Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Smo Prkar1b P4hb Prkar2b Mks1 Ift52 Dhh Ttc21b Syvn1 Ift57 Ptch1 Prkar1a Ift122 Ofd1 Prkar2a Wdr35 Os9 Dync2h1 Arrb2 Prkaca Arrb1 Sel1l Ift172 Cul3 Wdr19 Cdc73 Gpc5 Gli3 Gli2 Derl2 Spop Vcp Ulk3 Gpr161 Dzip1 Gli1 Spopl Intu Tulp3 Adcy10 Fuz Erlec1 Disp2 Hhat Gsk3b Csnk1a1 Adam17 Grk2 Sufu PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection Pycard Sugt1 P2rx7 P2rx4 Entpd1 Nt5e Entpd5 C3ar1 Il18 Nfkb1 Txn Hmox1 Hsp90ab1 Nlrp3 Pstpip1 Rela Ctsg Casp1 Nfkb2 Gsdmd Il1a Il1b Mefv C3 Txnip HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 96%1483115 Hydrolysis of LPC Pla2g4f Pla2g4c Pla2g4a Pla2g4e Gpcpd1 Pla2g4d Pla2g15 Plbd1 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors Anxa1 C3ar1 App Avpr2 Sstr3 Oxtr Npy Avpr1b Avpr1a Oxt Avp Cxcr4 Oprm1 Cxcl12 Ednra Npff Ednrb Trhr Nmbr Fpr2 Agtr1a Nmb Xcr1 Grpr Edn1 Edn3 Nms Nmu Cckar Nmur2 Mc1r Nmur1 Ntsr2 Mchr1 Ntsr1 Mc5r Brs3 Pdyn Galr2 Edn2 Galr3 Rxfp3 Cckbr Galr1 Rln3 F2 Rxfp2 Fpr1 Hcrt Rxfp1 Grp Mc4r Rln1 Kiss1r Pomc Insl3 Nps Rxfp4 Pnoc Insl5 Npffr1 Npffr2 Prok2 Qrfp Prok1 Npsr1 Fpr-s1 Agt Mc3r Ccr5 F2rl1 F2rl2 F2rl3 Prokr2 Ghsr Agtr2 Prokr1 Gpr37 Oprk1 Ccl17 Ccl11 Uts2 Cx3cl1 Tacr1 Ccl28 Tacr3 Ccl25 Tacr2 Ccl12 Ccl22 F2r Ccl20 Bdkrb2 Bdkrb1 Nts Prlhr Kng2 Ece1 Psap Tac3 Ccl7 Tac1 Ccl5 Pmch Ccl4 Ccl3 Ccl2 Trh Ccl1 Mrgprd Apln Oprd1 Qrfpr Sstr5 Xcl1 Sstr4 Kiss1 Kel Sstr2 Sstr1 Ppbp Ccr10 Nln Cx3cr1 Hcrtr2 Ppy Hcrtr1 Ccr1 Uts2b Npbwr1 Cck Uts2r Mc2r Ccr9 Pf4 Ccr8 Ccr7 Ccr6 Ccr4 Ccr3 Ccr2 Gal Penk Npb Npw Mas1 Cxcr1 Cxcr2 Npy1r Cxcr3 Xk Cxcr5 Cxcr6 Oprl1 Prlh Cxcl11 Hebp1 Cxcl10 Aplnr Ccrl2 Gper1 Pyy Cxcl16 Cxcl13 Npy5r Npy4r Saa3 Cxcl9 Sst Cxcl1 C5ar2 Cxcl2 C5ar1 Cxcl3 Cxcl5 Gpr37l1 Npy2r Ackr3 Ackr4 Ackr1 C3 Ackr2 C5 Cort CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447041 CHL1 interactions Itgb1 Chl1 Ank1 Nrp1 Itga10 Cntn6 Itga1 Hspa8 Itga2 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 96%453274 Mitotic G2-G2 M phases Nedd1 Actr1a Tuba1a Psma4 Tpx2 Psma3 Dctn2 Psma6 Dctn3 Psma5 Psma2 Psma1 Psmd12 Psmd11 Ywhae Psmd14 Cenpf Psmd13 Optn Ppp1cb Skp1 Cdc25c Psmb5 Psmb4 Cdc25b Psmb7 Cdc25a Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Pcnt Tuba4a Btrc Rbx1 Cep250 Psma7 Sdccag8 Psmc6 Cep78 Psmc5 Psmc2 Psmc1 Cep76 Psmc4 Psmc3 Cep72 Ubc Cep70 Psmd7 Fkbpl Psmd6 Tubb5 Ppp2r2a Gtse1 Plk4 Phlda1 Psmd8 Psmd3 Psmd2 Mnat1 Psmd1 Adrm1 Sem1 Cul1 Cep135 Mis18bp1 Cep131 Trp53 Prkar2b Ccnh Cdk7 Tubb4b Haus7 Tubb4a Haus8 Cdk5rap2 Mybl2 Fbxl7 Cep57 Pcm1 Aurka Ssna1 Tubg1 Ofd1 Cep63 Cep152 Haus3 Haus4 Haus5 Haus6 Sfi1 Csnk1d Haus1 Haus2 Hsp90aa1 Cep164 Prkaca Ccp110 Alms1 Cetn2 Tubgcp2 Rab8a Tubg2 Nme7 Tubgcp5 Tubgcp4 Fbxl18 Tubgcp3 Cep43 Mzt1 Mzt2 Cep41 Ppp1r12a Plk1 Ninl Cdk1 Nek2 Pkmyt1 Hsp90ab1 Fzr1 Cdk2 E2f1 Ccna1 Ccna2 E2f3 Lin54 Cdkn1a Lin9 Cpap Wee1 Clasp1 Lin37 Ywhag Pafah1b1 Ppp2cb Ppp2ca Sgo1 Csnk1e Foxm1 Mapre1 Rbbp4 Dynll1 Lcmt1 Obi1 Bora Ppme1 Ep300 Ticrr Ppp2r1b Cdk11b Ajuba Ppp2r1a Dync1h1 Hmmr Xpo1 Ccnb2 Dync1i2 Ckap5 Akap9 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 96%418457 cGMP effects Kcnmb2 Pde2a Pde1b Pde1a Itpr1 Kcnmb4 Prkg2 Pde10a Pde11a Kcnmb1 Kcnma1 Pde5a Pde9a Irag1 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8932506 DAG1 core M1 glycosylations Pomt1 Dag1 Pomt2 Pomgnt1 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases Polb Suds3 Psma4 Foxo4 Psma3 Psma6 Birc3 Psma5 Birc2 Psma2 Psma1 Ikbkg Map3k7 Traf2 Psmd12 Psmd11 Psmd14 Psmd13 Smurf2 Psmb5 Psmb4 Psmb7 Cdc25a Psmb6 Psmb1 Psmb3 Psmb2 Tada3 Trrap Psma7 Psmc6 Usp15 Psmc5 H2bc18 Snx3 Psmc2 Usp8 Psmc1 Ripk1 Psmc4 Vdac2 Psmc3 Ubc Vdac3 Psmd7 Psmd6 Vdac1 Becn1 Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Traf6 Trp53 Smad1 Ide Smad2 Tab1 Smad3 Smad4 Rnf146 Tnks2 H2ac20 Tnks Ar Smad7 Usp13 Myc Usp33 Wdr48 Usp10 Hif1a Cftr H2ac12 H2ac11 H2ac15 Axin2 Mul1 Hist1h2bp Rce1 Il33 Arrb2 Axin1 Ddb2 Gata3 Arrb1 Ccp110 Usp30 H2bc9 H2bc7 H2bc8 Usp9x H2bc3 Rhot1 Ruvbl1 Ptrh2 Wdr20 Ifih1 H2bu2 Stam2 Atxn7 Rigi Skp2 Usp3 Usp5 Hgs Mdm2 Mdm4 Ccna1 Ccna2 Tomm70 Kat2a Hist2h2aa1 Tgfbr1 Mat2b Cdc20 Usp2 Usp7 Usp21 H2bc14 Adrb2 Rnf128 Usp4 Cyld Fkbp8 H2bc21 H2bc26 Clspn Otub1 Pten Usp44 Usp42 H2ac21 Usp49 Usp48 H2ac25 Ufd1 Usp47 Hist1h2af H2ac1 Usp37 Usp14 Usp18 Rnf123 Usp22 Usp20 Usp26 Usp25 Usp28 Siah2 Usp12 Keap1 Usp16 Usp19 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis Abca12 Abcd1 Abcg4 Abca6 Pex3 Abcd2 Abcd3 Pex19 Abca2 Abca3 Abca5 Abca9 Abcg8 Abca7 Abcg5 Apoa1 Abcg1 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) Slc12a3 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 96%6807505 RNA polymerase II transcribes snRNA genes Ints4 Sp1 Ints5 Ints6 Ints7 Ints8 Ints9 Ints1 Ints2 Ints3 Nabp1 Nabp2 Pou2f2 IntS13 Ints14 Ints11 Ints12 Ints10 Zc3h8 Rprd2 Rpap2 Ice1 Ice2 Ssu72 Pou2f1 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 Supt5h Snapc5 Snapc3 Snapc4 Snapc1 Snapc2 Znf143 Cdk7 Srrt Ell Taf11 Taf13 Ccnk Tbp Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Phax Gtf2e2 Taf9 Ncbp2 Ncbp1 Supt4h1a Cdk9 Ccnt2 Ccnt1 Taf8 Ell2 Ell3 Taf6 Rprd1a Rprd1b Taf5 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 96%193692 Regulated proteolysis of p75NTR Psen2 Ncstn Aph1b Rela Ngfr Nfkb1 Traf6 Psen1 Adam17 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111469 SMAC, XIAP-regulated apoptotic response Diablo Apaf1 Xiap Casp3 Casp7 Casp9 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes Apoa4 Apoa5 Creb3l3 Lmf1 Lmf2 Lpl Gpihbp1 Angptl8 Angptl4 Angptl3 Apoc2 Furin Pcsk5 Lipc Pcsk6 Mbtps1 Mbtps2 Fgf21 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling Mmp9 Prmt1 Tgfa Elk1 Ereg Hbegf Btc Epgn Uhmk1 Mmp3 Foxo3 Sphk1 Src Igf1r Ccnd1 Egfr Pik3ca Mapk1 Ptk2 Mapk3 Cdkn1b Gnai2 Gnai1 Pdpk1 Gnai3 Esr2 Gnat3 Nras Gng10 Esr1 Hras Prkcz Egf Nos3 Bcl2 Akt3 Akt2 Gng3 Akt1 Areg Gng2 Gng4 Gng7 Strn Gng8 Srf Gngt1 Gngt2 S1pr3 Xpo1 Cav1 Gnb2 Fos Gnb1 Mmp2 Gnb4 Gnb3 Zdhhc7 Gnb5 Gng11 Hsp90aa1 Pik3r1 Zdhhc21 Pik3r2 Gng12 Gng13 Cav2 Mmp7 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 96%9013973 TICAM1-dependent activation of IRF3 IRF7 Tbk1 Traf3 Irf3 Ticam1 Tlr3 Ikbke Tank Optn Irf7 Ubc MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing Dnajc8 Rbm17 Ddx46 Ddx42 Dhx9 Ppp1ca Ppp1cb Ddx5 Sympk Cstf1 Papola Clp1 Nudt21 Cpsf1 Xrn2 Cstf2 Cpsf2 Hnrnpu Cstf3 Cpsf3 Cstf2t Wdr33 Ubc Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 Ybx1 Phf5a Hnrnpa2b1 Puf60 Smndc1 Pcbp2 Pcbp1 Hnrnpr Cpsf4 Papolg Sugp1 Hnrnpd Hnrnpf Hnrnpk Ccar1 Hnrnpl Prpf40a Hnrnpm Snrnp70 Htatsf1 Ppp1r8 Snrpa Rbmx Snrpc Rbm25 Hnrnph2 Srsf10 Tra2b Hnrnph1 Tut1 Ppp1r10 Tcerg1 Cpsf7 Rbm39 Hnrnpc Rbm5 Pabpn1 Fip1l1 U2surp Snrpb2 Snrpa1 Ptbp1 Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b2 Rnps1 Sf3b3 Sf3b4 Fyttd1 Sf3b5 Srsf1 Sf3b6 Thoc1 Thoc2 Thoc3 Thoc5 Srrt Thoc6 Thoc7 Srsf9 Ddx39a Cdc40 Snrpn Srsf7 Srsf6 Cherp Srsf3 Magoh Fus Ddx39b Srsf2 Srsf11 Srrm1 Hnrnpa3 Rbm8a Upf3b Zc3h11a Slu7 Poldip3 Alyref Hnrnpa1 Chtop Dhx38 U2af1l4 Snrpb Eif4a3 Rbm10 Casc3 Magohb Snrpd2 Snrpd1 Dhx15 Snrpd3 Srrm2 Ncbp2 Ncbp1 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9034864 Activated NTRK3 signals through RAS Ntrk3 Nras Sos1 Hras Ntf3 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME DATABASE ID RELEASE 96%9636249 Inhibition of nitric oxide production Nos2 Kpna1 Kpnb1 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 96%380108 Chemokine receptors bind chemokines Ccl28 Ccl25 Ccl12 Ccl22 Ccl20 Ccl7 Ccl5 Ccl4 Ccl3 Ccl2 Ccl1 Xcl1 Ppbp Ccr10 Cx3cr1 Ccr1 Ccr9 Pf4 Ccr8 Ccr7 Ccr6 Ccr4 Ccr3 Ccr2 Cxcr4 Cxcl12 Cxcr1 Cxcr2 Cxcr3 Cxcr5 Cxcr6 Cxcl11 Xcr1 Cxcl10 Ccrl2 Cxcl16 Cxcl13 Cxcl9 Cxcl1 Cxcl2 Cxcl3 Cxcl5 Ccr5 Ackr3 Ackr4 Ackr2 Ccl17 Ccl11 Cx3cl1 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis Hsd3b6 Srd5a3 Hsd3b1 Lhb Pomc Hsd17b3 Srd5a1 Srd5a2 Cyp17a1 Hsd17b12 Cga DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 96%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 Pomt1 Dag1 Pomt2 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen Adamts13 Vwf Gp9 Gp1bb Gp5 Gp1ba VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate Pnpo Aox1 Pdxk AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Cyp1a2 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME%R-HSA-9907570.1 Loss-of-function mutations in DLD cause MSUD3 DLDD Bckdhb Bckdha Dbt Dld REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 96%350864 Regulation of thyroid hormone activity Dio1 Dio2 Dio3 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 96%171319 Telomere Extension By Telomerase Nhp2 Acd Rtel1 Gar1 Terf2ip Tert Tinf2 Cdk2 Ccna1 Nop10 Ccna2 Terf2 Shq1 Terf1 Ruvbl2 Pif1 Ppp6r3 Ruvbl1 Pot1 Ppp6c Wrap53 Dkc1 Ankrd28 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) Brca1 H2bc14 H2bc9 H2bc7 Pias4 H2bc8 Prkdc Atm H2bc3 Xrcc6 Xrcc5 H2bc21 H2bc26 Kat5 H3c8 Trp53bp1 Abraxas1 Nbn Brcc3 Rnf168 Rif1 Paxip1 Nsd2 Lig4 Babam1 H2bu2 Babam2 Nhej1 Tdp2 Uimc1 Tdp1 Mdc1 Xrcc4 H2ax Polm Dclre1c Poll Hist1h2bp Bard1 Mre11a Herc2 Ube2v2 Ube2n Rad50 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy Rab7 Dusp16 GASTRULATION%REACTOME%R-HSA-9758941.6 Gastrulation Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Nog Foxa1 Notch1 Psma7 Psmc6 Psmc5 Ihh Psmc2 Psmc1 Psmc4 Psmc3 Shh Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Cxcr4 Adrm1 Sem1 Lfng Smad2 Smad3 Smad4 Zic1 Fgfr1 Pax3 Wnt3a Tcf7l1 Foxc2 Tcf7l2 Foxc1 Trim33 Zic2 Osr1 Pax2 Bmp4 Lhx1 Tead4 Pax8 Maml1 Maml2 Myb Rbpj Yap1 Gata4 Pou5f1 Tead2 Mamld1 Foxh1 Ctnnb1 Tcf7 Cdh1 Kat2b Kat2a Dlx5 Hes7 Noto Tbpl2 Pax7 Dll3 Mesp2 Msgn1 Msx1 Fgf2 Fgf4 Lef1 Pax6 Foxa2 Tfap2c Tfap2a Tfap2b Sox17 Mixl1 Ep300 Eomes T Gsc Gata6 Dll1 Sox2 Zeb2 Sox1 Fgf8 Znf521 Gbx2 Otx2 Tbx6 Pou3f1 Snai1 Epha4 Crebbp Foxf1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter Snapc5 Snapc3 Snapc4 Snapc1 Snapc2 Znf143 Brf2 Polr3gl Crcp Polr3a Polr3d Polr3e Polr1c Polr3b Polr3c Polr3h Polr3f Pou2f1 Polr1d Polr3g Polr3k Bdp1 Tbp Polr2h Polr2e Polr2f Polr2k REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME%R-HSA-9842860.2 Regulation of endogenous retroelements Zfp141 Actl6a Smarce1 Spocd1 Znf382 Dnmt3l H2bc9 H2bc7 H2bc8 H2bc3 Zcchc8 Gatad2a Gatad2b Ehmt2 Rbm7 H2ab2 Ehmt1 Mbd3 Pphln1 Actb H2bu2 Mta1 Zfp317 Mta3 Arid1a Arid1b Hist2h2aa1 Cbx5 Ss18 Dpf1 Dpf2 Dpf3 Ss18l1 H2bc14 Bcl7a Bcl7b H2ac20 Bcl7c Hdac2 Hdac1 Mphosph8 Zfp457 Ube2i Smarcb1 H2bc21 H2bc26 Rbbp4 Rbbp7 Morc2a Piwil4 Trim28 Smarca2 Smarca4 Chd3 ZNF418 Chd4 Smarcd1 Setdb1 H2ac12 Zfp324 Smarcd2 H2ac11 Atf7ip Zfp454 Dnmt3a Smarcc2 H2ac15 Smarcc1 H3c7 H2ax Smarcd3 Zfp708 Mta2 Mtrex Hist1h2bp H2aj Zfp354a SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 96%9703465 Signaling by FLT3 fusion proteins Trip11 Nras Myo18a Sos1 Stat5a Etv6 Stat5b Hras Pim1 Gab2 Zmym2 Nox4 Pik3ca Cdkn1a Sptbn1 Pik3r1 Golgb1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 96%397014 Muscle contraction Mylk Npr1 Gucy1a1 Myl6 Npr2 Gucy1a2 Corin Myl7 Nppc Itgb5 Sorbs1 Myl6b Anxa1 Sorbs3 Ttn Dmd Tnnt3 Tnnt2 Tnnt1 Tnnc2 Tnnc1 Tmod1 Tmod4 Aldh2 Tmod2 Tcap Neb Tnni2 Tnni1 Myl4 Des Myh3 Kcnk1 Mybpc1 Kcnk7 Mybpc2 Myl1 Kcnk6 Scn9a Actn3 Scn5a Mybpc3 Myl2 Myl3 Scn1a Myh8 Scn1b Myh6 Kcnip4 Kcnip1 Anxa2 Scn10a Scn2a Scn2b Scn7a Scn11a Scn3a Pxn Scn3b Nppa Kcnip3 Scn8a Fgf14 Cacng6 Cacna1c Scn4a Fgf12 Fgf13 Scn4b Fgf11 Ryr2 Fkbp1b Ryr1 Atp2a1 Dmpk Actn2 Atp1a2 Fxyd4 Atp1a1 Atp2a3 Fxyd1 Atp2a2 Atp1a3 Fxyd7 Sri Fxyd6 Kcnk5 Trdn Kcnk12 Kcnk15 Camk2g Ryr3 Camk2d Myl12a Ahcyl1 Camk2b Asph Camk2a Nos1 Slc8a1 Slc8a2 Atp1b1 Slc8a3 Atp1b3 Atp2b2 Cacna2d2 Atp1b2 Atp2b1 Atp2b4 Atp2b3 Orai1 Orai2 Prkaca Cacnb1 Gata4 Stim1 Cacnb2 Cacng8 Tnni3 Cacng4 Pak1 Kcnj11 Abcc9 Itpr3 Itpr2 Itpr1 Pak2 Kcnj2 Tln1 Vcl Pde5a Tmod3 Hipk1 Hipk2 Vim Kcnj4 Kat2b Wwtr1 Ces1d Mme Kcnj12 Kcnh2 Kcnq1 Kcna5 Kcnd3 Kcnd2 Kcnd1 Kcnk13 Kcnk10 Kcnk16 Kcnk18 Itga1 Kcnk4 Kcnk3 Kcnk2 Tbx5 Kcnk9 Kcnj14 Cacng7 Cacna1g Kcne5 Myl12b Kcne4 Cacna1h Kcne3 Kcne2 Anxa6 Myh11 Kcne1 Myl10 Gucy1b1 Trim72 Akap9 Lmod1 Cacna1i Mylpf Nkx2-5 Cav3 Tpm3 Tpm2 Trpc1 Dysf LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME%R-HSA-9865113.1 Loss-of-function mutations in DBT cause MSUD2 Bckdhb Bckdha Dbt Dld COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME DATABASE ID RELEASE 96%8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation Tnrc6c Ago4 Ago3 Ago2 Ago1 Tnrc6a Tnrc6b Mov10 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9035034 RHOF GTPase cycle Rhof Capzb Arhgap32 Diaph2 Farp1 Esyt1 Baiap2l1 Mtmr1 Syde1 Srgap2 Tmpo Arhgap39 Steap3 Basp1 Baiap2l2 Snap23 Rab7 Myo9b Lmnb1 Actb Add3 Tor1aip1 Akap12 Actn1 Arhgap12 Diaph3 Slc4a7 Depdc1b Vamp3 Diaph1 Arhgap5 Cav1 Arhgap1 Senp1 Sowahc Arhgap21 Vangl1 Mcam Pik3r1 Pik3r2 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-HSA-9734009.2 Defective Intrinsic Pathway for Apoptosis Trp53 C1qbp Cast Prdx2 App Jun Golga2 Prdx1 Capn1 Capn2 Cdkn2a Sod2 Cdk5r1 Bcl2l11 Ywhae Cdk5 Fasl Capns1 Capns2 Cdc25c Foxo3 Lmnb1 Cdc25b Cdc25a NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 96%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists Lrp6 Lrp5 Wif1 Wnt4 Sost Dkk1 Dkk2 Dkk4 Wnt5a Wnt9a Kremen2 Kremen1 Sfrp2 Sfrp1 Wnt3a MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import Grpel1 Cyc1 Hscb Fxn Bcs1l Pmpcb Slc25a12 Slc25a13 Tomm70 Pmpca Vdac1 Samm50 Chchd3 Mtx1 Mtx2 Timm50 Hspa9 Timm17b Cmc2 Atp5f1b Grpel2 Atp5f1a Timm9 Chchd7 Chchd4 Chchd5 Otc Hspd1 Tomm22 COA4 Timm44 Cox19 Cox17 Aco2 Pitrm1 Timm10 Slc25a5 Timm13 Timm8b Slc25a4 Cs Tomm40 Coq2 Coa6 Timm22 Timm21 Ldhd Chchd10 Tomm6 Gfer Tomm7 Tafazzin Idh3g Timm10b Ndufb8 Timm8a1 Dnajc19 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport Col4a1 Kdelr2 Col4a2 Copz2 App Copz1 Arf5 Golga2 Prdx1 Chmp2a Actr2 Arpc1a Ap2m1 Actr3 Ldlrap1 Ywhae Galnt2 Chmp3 Dvl2 Chmp7 Lrp1 Chmp6 Myo5a Arpc3 Arpc2 Ap2a2 Ap2a1 Arpc5 Arpc4 Ldlr Chmp4c Tmem115 Chmp4b Tmed9 Ap2b1 Wnt5a Ap2s1 Tmed3 Copg1 Copg2 Alb Copb2 Myo1c Copb1 Sbf1 Scarf1 Wasl Cd36 Marco Synj1 Msr1 Gns Colec12 Scgb3a2 Scara5 Fzd4 Fnbp1 Fnbp1l Cyth2 Cyth3 Golga5 Cyth4 Cyth1 Golim4 Snap29 C2cd5 Slc2a4 Tbc1d1 Rab10 Rab13 Tbc1d4 Rab14 Ralgapb Aspscr1 Hpx Ambp Hp Jchain Kif18b Use1 Kif26b Kifc2 Kif12 Nsf Kif21a Kif1c Kif21b Kif13b Kif1a Kif1b Bnip1 Gria1 Kif6 Kif9 Stx18 Stab2 Kif27 Rint1 Kif16b Kif20b Kif19a Surf4 Pafah1b1 Zw10 Rab27a Kif2a Kif2b Kif2c Dync1li2 Egf Dync1li1 Areg Dynll1 Dynll2 Kif18a Saa3 Dync1h1 Dync1i2 Dync1i1 Ap3b1 Sec13 Actr1a Mia3 Dctn2 Dctn3 Rab11a Rabgef1 Gga2 Gga1 Exoc3 Cenpe Rab4a Exoc4 Optn Gga3 Exoc5 Rabgap1 Tbc1d14 Exoc6 Tbc1d13 Exoc1 Tbc1d16 Exoc2 Tbc1d15 Rab11b Avpr2 Rab33b Exoc7 Rab33a Exoc8 Tbc1d17 Rabep1 Tbc1d2 Avp Rab35 Tbc1d7 Gabarapl2 Tbc1d10c Tjp1 Rab8b Tbc1d10b Tbc1d10a Ulk1 Sytl1 Tbc1d25 Gabarap Tbc1d24 Kif3a Kif3b Agpat3 Kif3c Pla2g6 Galnt1 Man2a1 Arf4 Prkaa2 Akt3 Hip1 Ssc5d Akt2 Cd5l Akt1 Kif26a Kif11 Kif15 Cftr Kif22 Kif23 Vps36 Kif20a Ubap1 Klc1 Tsg101 Klc4 Mvb12a Rab3ip Klc3 Cd163 Mvb12b Klc2 Vps37a Vps37b Cux1 Myh9 Vps37c Vta1 Vps37d Snf8 Vps25 Csnk1d Chmp5 Vps28 Rac1 Vps4a Vps4b Kifap3 Cd3g Cd3d Gbf1 Trip11 Rab8a S100a9 Chm Rab5a Rab9 Golga4 Rab5c Prkag3 Rab43 Rab5b Tmf1 Golga1 Vps51 Prkag1 Vps52 Prkag2 Cops5 Vps53 Vps54 Arl1 Stab1 Gcc2 Gcc1 Rab9b Cog1 Usp6nl Cog2 Stx6 Cog3 Ywhag Cog4 Kif5b Cog6 Cog7 Cog8 Igf2r Napa Napb Ric1 Scoc Naa35 Vti1a Naa38 Napg Rab6b Vamp4 Rab6a Rgp1 Naa30 Stx16 Arfip2 Rhobtb3 Cd4 Rabepk Arfrp1 Lman1 Rab7 Prkab2 Prkab1 Arfgap3 Arf3 Sbf2 Vamp3 Itsn1 Ins2 Stx4 Stx5 Capzb Gja1 Ykt6 Gjb2 Capza1 Capza2 Plin3 Spta1 Sptb Ank3 Ank1 Dnm1 Kif4 Sptan1 Hsph1 Dnm3 Agtr1a Sptbn1 Sptbn2 Sptbn4 Slc18a3 Gjd2 Gjc1 Sfn Hsp90aa1 Tacr1 Rab3a Clta Ereg Hbegf Cltc Btc Calr Epgn Cops3 Cops6 Arf1 Arfgap2 Dnajc6 Clvs1 Clvs2 Cops8 Dnase2a Cltb Cops7a Ctsz Vamp7 Cops7b Bloc1s1 Vamp8 Ap4s1 M6pr Txndc5 Ap1g2 Ap4m1 Dnm2 Hspa8 Gjb1 Egfr Ap4e1 Gja3 Gja5 Gja4 Gja8 Gjc2 Gjb4 Gjb3 Gjb6 Gjb5 Gjd4 Gjd3 Stxbp3 Als2 Sparc Pla2g4a Grk2 Man1a Man1a2 Rab27b Man1c1 Als2cl Gdi1 Gdi2 Rab3il1 Hsp90b1 Dennd4c Col1a2 Dennd4a Col1a1 Dennd4b Rab39b Lnpep Rab31 Rab32 Trappc8 Rab39 Rab38 Fcho1 Fcho2 Dennd5a Rab3gap1 D130043K22Rik Dennd1a Tor1a Arfgap1 Colec11 Dennd5b Dennd1b Tor1b Dennd1c Necap2 Necap1 Rin3 Apoe Scarb2 Rin1 Sgip1 Rin2 Bin1 Rab21 Itsn2 Chml Hip1r Mon1b Dab2 Dennd6a Mon1a Agfg1 Dennd6b Grk3 Snx9 Dennd2a Amph Dennd2b Snap91 Dennd2c Pik3c2a Dennd2d Hps1 Syt9 Rab12 Tgfa Syt8 Aak1 Rab18 Hps4 Synj2 Ctsc Trappc12 Scfd1 Gapvd1 Trappc11 Picalm Ppp6r1 Trappc13 Snx18 Ppp6r3 Lman2 Syt11 Rinl Slc2a8 Ankrd27 Sec22c Sec22b Ubqln2 Dennd3 Sec22a Epn2 Tfg Ubqln1 Preb Epn1 Trappc6b Ap1m2 Gak Ap1m1 Ppp6c Il7r Arf6 Trappc9 Ap1s3 Trappc6a Lrp2 Ap1s2 Ston2 Trappc5 Eps15l1 Trappc4 Ap1b1 Ap1s1 Sec31b Pacsin1 Trip10 Trappc3 Ap1g1 Sec31a Cttn Trappc2 Pacsin3 Trappc1 Pacsin2 F5 Reps2 F8 Pip5k1c Rab1a Stx17 Rab1b Trappc2l Gosr2 Ubc Lman1l Tbc1d20 Cd59b Uso1 Sec23ip Trappc10 Map1lc3b Sec16b Cpd Sec16a Mcfd2 Lman2l Serpina1d Cnih1 Tbc1d8b Sh3d19 Gorasp1 Golgb1 Cnih3 Ap3s1 Cnih2 Tpd52l1 Folr1 Dtnbp1 Ankrd28 Bet1 Yipf6 Snapin Snx2 Snx5 Bloc1s3 Bloc1s4 Bloc1s6 Acbd3 Pum1 Sort1 Ywhah Pafah1b3 Pafah1b2 Actr10 Dctn5 Dctn6 Dctn1 Dctn4 Capza3 Bicd2 Bicd1 Ywhaz Kdelr3 Hyou1 Arrb2 Arrb1 Vps45 Clint1 Myo6 Cops4 Cops2 Arcn1 Stam2 Sh3gl3 Rab30 Sh3kbp1 Stam Rab36 Eps15 Cbl Hgs Bet1l Sh3gl1 Sh3gl2 Tf Ftl1 Fth1 Kdelr1 Ywhab Ocrl Rala Chrm2 Tfrc Adrb2 Tsc2 Nedd8 Tsc1 Alppl2 Syt2 Racgap1 Syt1 Snap23 Vamp2 Copa Sar1b Sec23a Cope Hba-a1 Gosr1 Hbbt1 Col3a1 Sec24d Sec24c Col7a1 Apoa1 Sec24b Sec24a Apob ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex Rpa2 Rpa3 Cdc7 Pole Cdc6 Prim2 Orc5 Prim1 Orc4 Pola2 Orc6 Pola1 Orc1 Mcm8 Orc3 Orc2 Pole3 Mcm7 Pole2 Cdk2 Mcm3 Mcm4 Mcm5 Pole4 Mcm6 Cdc45 Mcm2 Cdt1 Gmnn Dbf4 Mcm10 Rpa1 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 96%5250958 Toxicity of botulinum toxin type B (botB) Syt2 Syt1 Vamp2 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 96%1614603 Cysteine formation from homocysteine Cth Cbs DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 96%5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Nup85 Gck Nup37 Sec13 Nup160 Gckr SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants Dkk4 Lrp5 Kremen2 Kremen1 Dkk1 Dkk2 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade Colec11 Mbl2 C1qc C3ar1 Vtn F2 Elane Cr2 Serping1 Cfh C5ar2 Cfi C5ar1 Clu C6 C7 C9 Cd59b Cd46 Cfhr1 Cfhr2 Pros1 Cd81 C8b C3 C8a Fcn2 Cpn1 C4a Crp C5 Cpn2 Cfd C8g Cfb C1qb C2 Cd19 C1qa Cpb2 C1rb Gzmm Colec10 C1s2 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 96%69190 DNA strand elongation Rpa2 Rpa3 Lig1 Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Prim2 Rfc1 Prim1 Rfc2 Pola2 Pold4 Pola1 Pold3 Mcm8 Gins2 Dna2 Gins1 Mcm7 Gins4 Gins3 Mcm3 Mcm4 Mcm5 Mcm6 Cdc45 Mcm2 Fen1 Rpa1 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway Sike1 Rnf135 Trim25 Mavs Rigi Irf7 Tbk1 Traf3 Irf3 Ikbke Ifnb1 Crebbp Ep300 Ifih1 DEFECTIVE B3GALTL CAUSES PPS%REACTOME%R-HSA-5083635.4 Defective B3GALTL causes PpS Adamts1 Adamts5 Adamts4 Adamts3 Adamts2 Adamts8 Adamts7 Adamts6 Sema5a Sema5b Thsd1 Thbs2 Thsd4 Adamts13 Adamts14 Adamts15 Adamts16 Cfp Adamts18 Adamts19 Spon2 Spon1 Adamts10 Sbspon Adamts12 B3glct Thsd7a Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Adamts20 Thsd7b Thbs1 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 96%450282 MAPK targets Nuclear events mediated by MAP kinases Ppp2cb Ppp2ca Mapk10 Mapk9 Mapk7 Mapk8 Jun Mapk11 Elk1 Rps6ka5 Atf2 Rps6ka1 Vrk3 Ppp2r1b Ppp2r1a Dusp3 Dusp4 Dusp7 Dusp6 Mef2a Mapk1 Mapk3 Fos Ppp2r5d Rps6ka3 Mef2c Rps6ka2 Mapkapk2 Mapk14 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body Lrp2 Ldlrap1 Cd320 Abcd4 Abcc1 Lmbrd1 Tcn2 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses Arsb Idua Gusb Galns Sgsh Glb1 Hgsnat Ids Gns Naglu Hyal1 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency Tpmt SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Amacr Akr1c18 Acot8 Hsd17b4 Cyp8b1 Ncoa2 Slc27a2 Ncoa1 Abcb11 Acox2 Rxra Nr1h4 Slc27a5 Baat Akr1c21 Hsd3b7 Cyp27a1 Akr1d1 Cyp7a1 Cyp7b1 Akr1c6 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%R-HSA-2474795.5 Diseases associated with visual transduction Opn1sw Rdh12 Lrat Stra6 Ttr Abca4 Rdh5 Rlbp1 Rbp4 Napepld Opn1mw Rbp1 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 96%1227990 Signaling by ERBB2 in Cancer Nrg3 Cdc37 Erbin Nras Gab1 Nrg1 Plcg1 Ptpn12 Sos1 Hras Egfr Pik3ca Erbb2 Egf Shc1 Ereg Hbegf Btc Hsp90aa1 Pik3r1 Nrg2 Nrg4 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8849175 Threonine catabolism Rida Sds Sdsl TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex Pcna Tfdp2 Tfdp1 E2f4 E2f5 Hdac1 E2f1 Cdc6 Rbl2 Myc Max Lin54 Rbbp4 Lin9 Rbl1 Lin37 Top2a Cdc25a ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-HSA-170670.5 Adenylate cyclase inhibitory pathway Gnat3 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Gnal Gnai2 Gnai1 Gnai3 TRANSLATION%REACTOME DATABASE ID RELEASE 96%72766 Translation Sec61b Srp68 Ssr4 Ssr3 Ssr2 Srp72 Rbx1 Srp9 Tram1 Srp14 Srp54 Srp19 Ube2d3 Gspt2 ATP6 Gspt1 mt-Nd4 mt-Nd5 Cul2 mt-Nd6 Gfm2 mt-Nd1 mt-Nd2 Pabpc1 mt-Nd3 Mrrf Mtrf1 Mtrf1l mt-Nd4l Etf1 Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Ascc3 Rps11 Ascc2 Rpl7 Gars1 Lars2 Nars2 Rpl32 Tars2 Rps9 Iars2 Cars2 Rps7 Rps5 Vars2 Rpl24 Ears2 Wars2 Rpl26 Aars2 Rpl22 Rpl23 Rars2 Pars2 Ppa2 Mars2 Rps25 Dars2 Rps26 Yars2 Sars2 Hars2 Rps21 Fars2 Abce1 Rpl39l Pelo Rps15a Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Znf598 Ankzf1 Klhdc10 Tcf25 Trmt112 Hemk2 Eif3m Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Eif4h Wars1 Eif3j2 Aars1 Eif1ax Mief1 Eif4a2 Mtres1 Eif4a1 Hars1 Tars1 Eef1a2 Yars1 Eef1d Cars1 Eef1g Mtfmt Eef1b Rps27 Nars1 Eef2 Vars1 Farsa Farsb Mtif3 Mtif2 Ppa1 Psma4 Psma3 Eif2b3 Psma6 Eif2b2 Psma5 Eif2b5 Psma2 Eif2b4 Psma1 Eif2s3x Eif2b1 Eif2s2 Psmd12 Eif2s1 Psmd11 Psmd14 Psmd13 Psmb5 Apeh Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Ltn1 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Lars1 Eef1e1 Kars1 mt-Co1 Srprb Srpra Rpn2 Rpn1 Mars1 Dars1 Qars1 Rars1 Aimp2 Ssr1 Aimp1 Eprs1 Iars1 Eif5b Eif5 Mrpl10 Mrpl54 Dap3 Mrpl11 Mrpl55 Tsfm Mrpl12 Gfm1 Mrpl13 Mrpl57 Mrpl58 Mrpl14 Mrps30 Mrpl16 Mrps31 Mrpl17 Mrps33 Mrpl18 Mrpl19 Aurkaip1 Mrps34 Mrps35 Tufm Gadd45gip1 Mrpl20 Mrpl3 Mrpl43 Mrpl4 mt-Co2 Mrpl44 mt-Co3 Mrpl1 Mrpl46 Mrpl2 Mrpl47 Mrpl48 Ndufab1 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Ube2d1 Rchy1 Mrpl9 Mrps25 Mrps26 Sec11c Mrps27 Sec11a Mrps28 Mrps18c Mrps18b Mrps18a Mrpl50 Mrpl51 mt-Cytb Mrpl52 Vcp Mrpl53 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrps9 Mrpl36 Mrpl37 Mrpl38 Mrpl39 Mrps10 Mrps11 Mrps12 Mrps14 Chchd1 Mrps15 Mrps16 Mrps17 Ptcd3 Mrps2 Mrps6 Eif4ebp1 Mrps7 Eif4g1 Mrpl40 Ddost Mrpl41 Mrps5 Mrpl21 Mrpl22 Mrpl24 Mrpl28 Eral1 Mrpl30 Sars1 Eif4b Eif4e Ufd1 Nploc4 Spcs3 Spcs1 Spcs2 Sec61a2 Sec61a1 Eloc ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-HSA-176187.4 Activation of ATR in response to replication stress Rpa2 Rad17 Rpa3 Rad1 Cdc7 Cdc6 Clspn Cdc25c Rfc5 Rfc3 Cdc25a Rfc4 Orc5 Orc4 Rfc2 Orc6 Orc1 Mcm8 Hus1 Orc3 Atrip Orc2 Mcm7 Cdk2 Mcm3 Mcm4 Chek1 Mcm5 Mcm6 Rad9a Cdc45 Mcm2 Rad9b Dbf4 Mcm10 Rpa1 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME%R-HSA-9931530.2 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Ppp1cc Per1 Per3 Csnk1d Cdk5 Csnk1e Ppp1ca Ppp1cb Csnk2a2 Cry1 Csnk2b Cry2 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF Elmo2 Flt4 Cyfip1 Bcar1 Aamp Prkacb Vegfa Sphk1 Cyfip2 Prkcb Nrp2 Itgav Ptk2 Wasf3 Pxn Prkca Nrp1 Trib3 Nck2 Shb Sh2d2a Nck1 Nos3 Akt3 Akt2 Akt1 Hspb1 Flt1 Ahcyl1 Rac1 Cav1 Vav1 Hsp90aa1 Pik3r1 Pik3r2 Vav3 Prkaca Jup Pak1 Itpr3 Itpr2 Vav2 Rasa1 Itpr1 Pak3 Pak2 Ptk2b Itgb3 Rictor Pgf Rock2 Ctnnb1 Rock1 Pik3cb Ctnnd1 Kdr Pik3ca Shc2 Axl Prr5 Ncf1 Mapk12 Ncf2 Ncf4 Pdpk1 Mapkapk3 Brk1 Mapk13 Mapkapk2 Mapk14 Cdh5 Them4 Baiap2 Nckap1l Mlst8 Nras Plcg1 Crk Mtor Hras Rhoa Mapk11 Nckap1 Prkcz Fyn Wasf2 Wasf1 Cyba Mapkap1 Abi2 Abi1 Cybb Prkcd Vegfd Vegfc Vegfb Elmo1 Ctnna1 Dock1 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 96%888590 GABA synthesis, release, reuptake and degradation Aldh5a1 Rab3a Dnajc5 Slc6a11 Cplx1 Slc6a13 Abat Gad1 Gad2 Hspa8 Slc6a1 Snap25 Syt1 Vamp2 Stx1a Slc6a12 Slc32a1 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702605 pexidartinib-resistant FLT3 mutants Flt3 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME%R-HSA-9022537.2 Loss of MECP2 binding ability to the NCoR SMRT complex Ncor2 Hdac3 Ncor1 Gps2 Tbl1xr1 Tbl1x BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters Slc4a8 Ahcyl2 Slc4a9 Slc4a1 Slc4a4 Slc4a10 Slc4a7 Slc4a2 Slc4a3 Slc4a5 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-HSA-168928.12 DDX58 IFIH1-mediated induction of interferon-alpha beta Pcbp2 Atg5 Irf7 Atg12 App Ikbkb Isg15 Traf3 Ikbkg Traf2 Ikbke Tank Nfkb1 Ube2d1 Ube2k Ifih1 Hsp90ab1 Fadd Sike1 Rnf135 Trim25 Mavs Rela Rigi Itch Casp8 Ripk1 Ube2d3 Ubc Tomm70 Nfkbib Ifnb1 Nfkbia Traf6 Chuk Uba7 Pin1 Cyld Tnfaip3 Tbk1 Irf3 Nkiras1 Nkiras2 Ep300 Map3k1 Dhx58 Rnf216 Saa3 S100b Tkfc Tax1bp1 Ager Nlrx1 Nfkb2 Ube2l6 Crebbp Hsp90aa1 Otud5 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation Pak1 Map2k4 Mapk10 Vav2 Nras Mapk9 Pak2 Plcg1 Mapk8 Sos1 Grap2 Hras Jun Plcg2 Lyn Map3k1 Lcp2 Rac1 Mapk1 Syk Mapk3 Fos Vav1 Map2k7 Vav3 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins Nup43 Ranbp2 Nup93 Nup50 Pias4 Nup35 Nup54 Pom121 Nup205 Ube2i Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Nup85 Topors Nup37 Sec13 Nup160 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 96%380994 ATF4 activates genes in response to endoplasmic reticulum stress Ccl12 Asns Herpud1 Atf3 Atf6 Cebpg Igfbp1 Atf4 Exosc9 Exosc8 Exosc5 Dis3 Nfyb Exosc4 Nfya Exosc7 Nfyc Ddit3 Exosc6 Parn Exosc1 Exosc3 Exosc2 Dcp2 Cebpb TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME%R-HSA-168271.5 Transport of Ribonucleoproteins into the Host Nucleus Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Kpna1 Aaas Nup214 Nup210 Nup155 Nup153 Nup85 Kpnb1 Nup37 Sec13 Nup160 MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME DATABASE ID RELEASE 96%9816359 Maternal to zygotic transition (MZT) Cnot6l H2bc9 H2bc7 H2bc8 H2bc3 Hira Mettl23 H2ab2 Aicda Kdm5a Kdm6a Stpg4 Uhrf1 Kdm6b Tet3 H2bu2 Srpk1 Pabpn1 Prm2 Npm2 H1.8 Hist2h2aa1 Cnot3 Cnot2 Cnot1 Cnot7 Cnot6 Eif4g1 Cnot4 Cnot9 Trp53 Cnot8 H2bc14 Cnot11 Pabpc1 Tut7 H2ac20 Tut4 Paip1 Kdm5b Eif4b Eif4e H2bc21 Eif4a2 Eif4a1 H2bc26 Cnot10 Ep300 H2ac12 H2ac11 Tnks1bp1 Ago2 Eif4a3 H2ac15 H3c7 H2ax Btg4 Tead4 Zfp36l2 Pabpn1l Dis3l2 Hist1h2bp Dicer1 H2aj Crebbp Yap1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling Uba7 Pcbp2 Pin1 Atg5 Atg12 Cyld Tnfaip3 Isg15 Tbk1 Traf3 Irf3 Ikbke Ube2d1 Ube2k Ifih1 Rnf216 Rnf135 Trim25 Mavs Rigi Itch Tax1bp1 Ube2d3 Ubc Nlrx1 Ube2l6 Otud5 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases Trp73 Trp53 Casp6 Casp2 Apaf1 Trp63 Cradd Pidd1 Nlrc4 Casp1 Atm FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC Cct3 Tcp1 Cct2 Cct6b Cct6a Cct8 Cct7 Cct5 Actb Cct4 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 96%194441 Non-coding RNA Metabolism Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Gemin7 Gemin4 Gemin5 Snrpb Prmt5 Smn1 Snupn Snrpd2 Snrpd1 Nup85 Clns1a Phax Snrpd3 Gemin2 Ncbp2 Ddx20 Ncbp1 Wdr77 Nup37 Sec13 Nup160 RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9833110 RSV-host interactions Tlr4 Med26 Cd209d Med27 Med12 Med13 Med14 Med10 Tyk2 Havcr2 Med15 Med16 Isg15 Med17 Gpc1 Ifnar1 Gpc3 Gpc2 Cd14 Tlr6 Gpc5 Tlr2 Arih1 Gpc4 Stat2 Gpc6 Ifih1 Trim25 Mavs Rigi Cx3cr1 Rbx1 Oas2 Ubc Agrn Becn1 Med22 Ifnb1 Med21 Med28 Med29 Med11 Med19 Med18 Med30 Med31 Bcap31 H2bc14 Cd209a Irf3 Cul5 Hspg2 Sdc4 Sdc3 Sdc2 Ep300 Cdk8 Sdc1 Med9 Ube2l6 Cdk19 Eif2ak2 Med1 Med13l Jak1 Tlr7 Map1b Tlr3 Med8 Ccnc Ly96 Crebbp Med23 Med4 Med24 Med6 Med25 Med20 Eloc FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing Tial1 Hnrnpa1 Tia1 Esrp2 Rbfox2 Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Hnrnpf Polr2b Polr2g Polr2h Ptbp1 Polr2e Hnrnpm Polr2f Polr2k Polr2i Polr2j Hnrnph1 Gtf2f2 Gtf2f1 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex Smarcd1 Ss18 Actl6a Smarcd2 Smarce1 Dpf2 Bcl11b Phf10 Smarcc2 Smarcc1 Bcl7a Arid1a Bcl7b Bcl7c Smarcd3 Smarcb1 Bcl11a Smarca4 Actb FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-HSA-9933937.1 Formation of the canonical BAF (cBAF) complex Smarcd1 Ss18 Actl6a Dpf1 Smarce1 Dpf2 Dpf3 Ss18l1 Smarcc1 Bcl7a Arid1a Bcl7b Arid1b Bcl7c Smarcb1 Smarca2 Smarca4 Actb RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%73863 RNA Polymerase I Transcription Termination Gtf2h3 Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Polr1c Polr1d Tbp Ttf1 Cavin1 Polr1b Polr1a Polr1g Polr1e Polr1h Taf1d Polr2h Taf1a Polr2e Taf1c Polr2f Taf1b Polr2k Mnat1 Ubtf Gtf2h2 Gtf2h1 Gtf2h4 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants Arrb1 Jak2 Fgb Fga Rap1b Map2k2 Ksr1 Vwf Cnksr2 Nras Cnksr1 Fgg Map2k1 Araf Mark3 Itgb3 Pebp1 Raf1 Hras Tln1 Map3k11 Fn1 Vcl Csk Itga2b Src Camk2g Camk2d Camk2b Kras Camk2a Mapk1 Braf Mapk3 Ywhab Rap1a Brap Phb1 Apbb1ip Arrb2 Iqgap1 O-LINKED GLYCOSYLATION%REACTOME%R-HSA-5173105.10 O-linked glycosylation Galnt3 Muc15 Muc13 Mmrn1 Pomgnt1 Galnt12 Adamts1 Adamts5 B3gnt9 Adamts4 B3gnt8 Qtgal Adamts3 Adamts2 B3gnt6 Adamts8 B3gnt5 Adamts7 Galntl5 Adamts6 Galnt2 Galnt5 Sema5a Galnt4 Sema5b Galnt7 C1galt1 Thsd1 Galnt6 Thbs2 Galnt10 C1galt1c1 A4gnt Thsd4 Galnt17 Galnt18 Slc35a4 Adamts13 Galnt15 Adamts14 Galnt16 B3galnt2 Adamts15 Large1 Galnt13 Galnt14 Adamts16 Chst10 Cfp Galnt11 Gcnt7 Adamts18 Gcnt3 Adamts19 Spon2 Chst4 Gcnt1 Muc1 Spon1 Adamts10 Sbspon Adamts12 B3glct Muc4 Muc6 Thsd7a Muc20 Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Large2 Adamtsl5 Pomt1 Adamts20 Dag1 Thsd7b Pomt2 Galnt1 St6galnac3 St6galnac4 St6galnac2 St3gal4 St3gal2 St3gal1 St6gal1 B4galt5 B4galt6 B4gat1 Slc35a1 B3gnt3 B3gnt7 B3gnt4 B3gnt2 Mgat5b Crppa Rxylt1 Fkrp Fktn Pomgnt2 Pofut2 Pofut3 Pofut4 Emid1 Mmrn2 Pomk Thbs1 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9026519 Activated NTRK2 signals through RAS Nras Bdnf Ntf4 Sos1 Ntrk2 Hras CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%379716 Cytosolic tRNA aminoacylation Qars1 Rars1 Lars1 Aimp2 Aimp1 Eef1e1 Eprs1 Iars1 Kars1 Sars1 Wars1 Aars1 Ppa1 Hars1 Tars1 Yars1 Cars1 Nars1 Gars1 Vars1 Mars1 Farsa Farsb Dars1 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 96%6798695 Neutrophil degranulation Clec5a Ddx3x Ppia Cnn2 Mmp9 C3ar1 Cyb5r3 Capn1 Actr2 Sdcbp Ap2a2 Npc2 Elane Arpc5 Slc44a2 Ctsg Bst1 Gsdmd Fcgr3 Fgr Copb1 Idh1 Pycard Plaur Gsn Adgre5 P2rx1 Frk Cd36 Cpne1 Cpne3 Gns B4galt1 Plac8 Snap29 Prdx6 Manba Rab10 Pgam1 Hvcn1 Rab14 Gaa Man2b1 Hp Dera Aldoc Aldoa Hexb Prtn3 Surf4 Glb1 Aoc1 Cd44 Pygb Agl Pygl Arsb Gusb Cd300a Gyg1 Itgax Itgam Pdxk Itgb2 Rab27a Cd47 Pkm Hpse Dync1li1 Naprt Hk3 Dsn1 Acly Atp8a1 Dynll1 Eef2 Adam10 Pgm2 Atp11b Atp11a Pgm1 Dync1h1 Alox5 Ilf2 C3 Pfkl Chit1 Mgam Ano6 Fuca2 Galns Plau Serpinb6a Ist1 Ticam2 Cd14 Apeh Commd9 Dsp Tbc1d10c Pkp1 Dsg1a Aprt Tubb5 Pnp Lpcat1 Ampd3 Mmp25 Commd3 Agpat2 Golga7 Asah1 Actr1b Adam8 Ctsh Mmp8 Fpr1 Lamp2 Sell Sirpa Olr1 Rac1 Retn Lgals3 Sirpb1b Magt1 Armc8 Psap Cdk13 S100a9 S100a8 Gpi Lair1 Ttr Ppbp Vcp Siglec12 Rab5c Tspan14 Rab5b Cst3 Oscar Gpr84 Prss2 Rab9b Mme Atp6ap2 Ddost Igf2r Csnk2b Cxcr1 Anpep Cxcr2 Rab6a Ptpn6 Rhoa Bpi Rab7 Rhog Kcnab2 Itgal Iqgap2 Cxcl3 Stbd1 Pld1 Dock2 Apaf1 Ndufc2 Cda Cyfip1 Timp2 Cct2 Ctsd Fabp5 Cfp Dgat1 Srp14 Itgav Slco4c1 Anxa2 Cct8 Sptan1 Mgst1 Tubb4b Fpr2 Nfasc Cap1 Ckap4 Ptafr Ctsa Tollip Slc11a1 Kpnb1 Hsp90aa1 Neu1 Rab3a Dnajc5 Arhgap9 Dnajc3 Hspa1a Mospd2 Ctsz Vamp8 Txndc5 Hspa8 Vnn1 Arhgap45 Faf2 Rhof Fcer1g Slc15a4 Tnfrsf1b Hgsnat Arsa Cd177 Slc2a3 A1bg Prkcd Orm3 Mmtag2 Clec4d Padi2 Nbeal2 Clec4b2 Prdx4 Pgrmc1 Cystm1 C5ar1 Flg2 Ptprn2 Ahsg Pa2g4 Ctsb S100a11 Ctss Rnase2a Rnase2b Gdi2 Clec12a Serpina3n Tmt1a Cd63 Syngr1 Glipr1 Tmc6 Fcn2 Pglyrp1 Rab31 Cfd Atg7 Ptges2 Grn Enpp4 Ypel5 Nfam1 Aga Pigr Crispld2 Ormdl3 Qsox1 Lrg1 Plekho2 Adgrg3 Epx Kcmf1 Serpinb1a Sting1 Serpinb12 Trpm2 Bri3 Pecam1 Serpinb3d Ptprb Ghdc Lamp1 Arl8a Nit2 Psma5 Chi3l1 Xrcc6 Psma2 Acp3 Xrcc5 Crisp1 Rab18 Olfm4 Ctsc Atad3a Psmd12 Fgl2 Psmd11 Dnase1l1 Psmd14 Gm2a Huwe1 Psmd13 Slpi Nfkb1 Nhlrc3 Mcemp1 Scamp1 Krt1 Prcp Psmb7 Ap1m1 Tmem179b Cant1 Psmb1 Unc13d Calm4 Tmem30a Vat1 Prg3 B2m Prg2 Rap2b Trappc1 Rap2c Ptprj Camp Abca13 Psmc2 Cd53 Stk11ip Irag2 Psmc3 Cstb Gca Rnaset2a Psmd7 Cd59b Erp44 Psmd6 Creg1 Mpo Cd68 Dok3 Psmd3 Hebp2 Psmd2 Cd93 Psmd1 Cotl1 Serpina1d Dpp7 Aldh3b1 Ubr4 Tarm1 Degs1 Tmbim1 Cracr2a Cpped1 Mvp Ms4a3 Pdap1 Tmem63a Cmtm6 Dsc1 Tnfaip6 Vps35l Ostf1 Ptx3 Gla Alad Dbnl Pafah1b2 Actr10 Cat Tyrobp Ptprc Diaph1 Vapa Stom Iqgap1 Jup Impdh1 Stk10 Nme2 Rap1b Vcl Lta4h Fuca1 Tlr2 Hsp90ab1 Chrnb4 Rab37 Acaa1a Rock1 Slc27a2 Ltf Hmox2 Rab4b Bin2 Atp6v0a1 Rab3d Ftl1 Mapk1 Fth1 Cand1 Rab24 Rap1a Mapk14 Tcirg1 Cab39 Nckap1l Nras Lamtor1 Lamtor2 Atp6v1d Lcn2 Arg1 Mlec Snap25 Snap23 Cyba Cybb H2-Q1 Bst2 Slc2a5 Psen1 Ncstn Hbbt1 Ppie Mif DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 96%4570571 Defective RFT1 causes CDG-1n Rft1 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport Tnpo1 Ift52 Trip11 Dync2li1 Dync2i1 Dync2i2 Dynlrb2 Ift172 Ttc21b Dynlrb1 Wdr19 Ift56 Ift70b Ift57 Dynlt2a1 Ift88 Ift81 Dynll1 Dynll2 Cluap1 Ift122 Dynlt2b Ift43 Ift80 Kif17 Traf3ip1 Ift46 Ift140 Dynlt5 Wdr35 Ift74 Ift22 Kif3a Kif3b Ift27 Kif3c Kifap3 Ift25 Dync2h1 Ift70a1 APAP ADME%REACTOME%R-HSA-9753281.3 APAP ADME Cndp2 Ugt1a6 Gstt1 Ugt1a9 Abcc4 Gstm2 Ugt1a1 Nat1 Abcc5 Nat2 Ugt2b36 Ggt1 Abcc3 Acy1 Sult1e1 Sult1a1 Abcc2 Abcg2 Abcc1 Sult2a1 Ggt7 Ggt5 Cyp2e1 Ggt6 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 96%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) Dhcr7 Sc5d Dhcr24 Ebp MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation Mrpl14 Mrps30 Mrpl16 Mrps31 Mrpl17 Mrps33 Mrpl18 Mrpl19 Aurkaip1 Mrps34 Mrps35 Gadd45gip1 Mrpl20 Mrpl3 Mrpl43 Mrpl4 Mrpl44 Mrpl1 Mrpl46 Mrpl2 Mrpl47 Mrpl48 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrpl9 Mrps25 Mrps26 Mrps27 Mrps28 Mrps18c Mrps18b Mrps18a Mrpl50 Mrpl51 Mrpl52 Mrpl53 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrps9 Mrpl36 Mrpl37 Mrpl38 Mrpl39 Mrps10 Mrps11 Mrps12 Mrps14 Chchd1 Mrps15 Mrps16 Mrps17 Ptcd3 Mrps2 Mrps6 Mrps7 Mrpl40 Mrpl41 Mrps5 Mrpl21 Mrpl22 Mrpl24 Mrpl28 Eral1 Mrpl30 Mtfmt Mtif3 Mtif2 Mrpl10 Mrpl54 Dap3 Mrpl11 Mrpl55 Mrpl12 Mrpl13 Mrpl57 Mrpl58 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins Phyh Hsd17b4 Tysnd1 Acaa1a Scp2 Agps Acox1 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%5653890 Lactose synthesis Lalba B4galt1 Slc2a1 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 96%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells Neurog3 Onecut3 Onecut1 Mamld1 Notch1 Hnf1b Kat2b Maml1 Maml2 Kat2a Rbpj Crebbp Hes1 Ep300 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 96%111931 PKA-mediated phosphorylation of CREB Prkar2a Prkaca Prkar2b Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Prkx Adcy6 Adcy9 Prkar1a Prkacb Prkar1b BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717319 brigatinib-resistant ALK mutants Alk GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis Arrb1 Necap1 Hip1r Snx9 Clint1 Pik3c2a Picalm Gak Ap1m2 Arf1 Ap1m1 Dnajc6 Ap1s3 Ap1s2 Ap1b1 Ap1s1 Ap1g1 Vamp7 Bloc1s1 Vamp8 Rab5c Txndc5 Dnm2 Sh3gl2 Hspa8 Ap4e1 Ftl1 Fth1 Cpd Tbc1d8b Sh3d19 Ocrl Golgb1 Ap3s1 Tpd52l1 Igf2r Napa Dtnbp1 Yipf6 Snapin Tfrc Snx2 Snx5 Bloc1s3 Bloc1s4 Bloc1s6 Acbd3 Pum1 Sort1 Vamp2 Ap3b1 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963676 Intestinal absorption Slc2a2 Slc5a1 Slc2a5 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%352230 Amino acid transport across the plasma membrane Slc43a1 Slc43a2 Slc7a11 Slc7a10 Slc25a29 Slc3a1 Slc38a5 Slc38a4 Slc1a5 Slc38a3 Slc38a2 Slc36a4 Slc1a4 Slc3a2 Slc7a3 Slc7a1 Slc6a6 Slc6a19 Slc7a6 Slc7a7 Slc7a5 Slc6a15 Slc38a1 Slc6a14 Slc36a2 Slc7a8 Slc36a1 Slc7a9 Slc6a12 Slc6a20a DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B Ggcx Gp9 F8 Gp1bb F9 Gp5 F10 Gp1ba DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-HSA-606279.3 Deposition of new CENPA-containing nucleosomes at the centromere Cenpc1 Itgb3bp Knl1 Cenpu Cenpt Cenps H2bc14 Cenpq H2bc9 Cenpp H2bc7 H2ac20 H2bc8 Cenpo Cenpn H2bc3 Cenpm Cenpl H2bc21 Cenpk H2bc26 Cenpi Cenph Rbbp4 Ruvbl1 Rbbp7 H2ab2 H2bu2 H2ac12 H2ac11 Npm1 H2ac15 Smarca5 H2ax Hist1h2bp Hist2h2aa1 Cenpa H2aj Rsf1 Oip5 Mis18a Cenpx Cenpw Mis18bp1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME%R-HSA-5632927.2 Defective Mismatch Repair Associated With MSH3 Msh2 Msh3 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%9661070 Defective translocation of RB1 mutants to the nucleus Rb1 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME DATABASE ID RELEASE 96%6791461 RPIA deficiency: failed conversion of RU5P to R5P Rpia IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%975163 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation Tlr4 Tab3 Ticam2 Tab2 Map3k7 Ticam1 Tab1 Cd14 Ly96 Traf6 Irak2 Ubc RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5213460 RIPK1-mediated regulated necrosis Mlkl Birc3 Birc2 Peli1 Tradd Traf2 Sdcbp Prkn Fasl Xiap Tnfsf10 Tnfrsf10b Fadd Ube2l3 Flot2 Flot1 Cdc37 Itch Ripk3 Casp8 Ripk1 Stub1 Ubc Pdcd6ip Fas Ogt Hsp90aa1 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72163 pre-mRNA splicing Lsm5 Dnajc8 Rbm22 Lsm6 Lsm7 Rbm17 Ddx46 Ddx41 Ddx42 Sap18b Dhx9 Ppil2 Ddx23 Ddx5 Hnrnpu Znf830 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 Ybx1 Prpf4 Leng1 Prpf3 Fam50a Prpf31 Zmat2 Cactin Pnn Rnf113a2 Sf1 Rbmx2 Nsrp1 Tfip11 Prpf18 Ik Dhx8 Wdr70 Snip1 Fam32a Steep1 Dhx35 Yju2 Smu1 Lsm8 Gpatch1 Ppwd1 Snrnp27 Gcfc2 Ccdc12 Ubl5 Syf2 Phf5a Prpf4b Sde2 Usp39 Crnkl1 Sart1 Wbp4 Cwf19l2 Mfap1b Prpf38a Prkrip1 Nkap Mtrex Rbm42 Luc7l3 Bud13 Xab2 Hnrnpa2b1 Prpf19 Puf60 Bcas2 Gpkow Smndc1 Aqr Pcbp2 Pcbp1 Hnrnpr Sugp1 Hnrnpd Hnrnpf Hnrnpk Ccar1 Hnrnpl Prpf40a Hnrnpm Snrnp70 Htatsf1 Rbm7 Ppp1r8 Snrpa Rbmx Snrpc Rbm25 Hnrnph2 Srsf10 Tra2b Hnrnph1 Cwc22 Tcerg1 Cwc27 Rbm39 Cwc25 Hnrnpc Cwc15 Rbm5 Txnl4a Hspa8 Snrnp200 U2surp Snrpb2 Snrpa1 Ptbp1 Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b2 Rnps1 Sf3b3 Sf3b4 Sf3b5 Srsf1 Sf3b6 Ctnnbl1 Srrt Snrnp40 Eftud2 Srsf9 Cdc40 Snrpn Srsf7 Srsf6 Cherp Srsf3 Magoh Fus Ddx39b Isy1 Srsf2 Cdc5l Srsf11 Plrg1 Srrm1 Hnrnpa3 Rbm8a Upf3b Ppil4 Slu7 Ppil3 Acin1 Alyref Hnrnpa1 Dhx38 Ppil1 U2af1l4 Prcc Snrpb Eif4a3 Rbm10 Casc3 Magohb Snrpd2 Dhx16 Snrpd1 Dhx15 Snrpd3 Srrm2 Ncbp2 Ncbp1 Prpf6 Ppig Ppih Ppie Prpf8 Wbp11 Lsm2 Lsm3 Lsm4 Pqbp1 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 96%163125 Post-translational modification: synthesis of GPI-anchored proteins Gpld1 Meltf Thy1 Pigc Pigb Piga Pigk Pigm Alpi Pigl Pigg Pigf Pigh Gp2 Pigs Pigu Pigt Pigo Spaca4 Pign Pigz Pigw Pigx Rtn4rl2 Tecta Rtn4rl1 Ly6g6c Tectb Ly6g6d Sprn Pgap1 Msln Reck Nrn1 Art4 Art3 Ly6k Bst1 Gpihbp1 Izumo1r Ntng1 Lsamp Ly6h Ly6d Cpm Ly6e Negr1 Tex101 Opcml Vnn1 Prnd Vnn3 Lypd8 Lypd5 Lypd4 Lypd3 Lypd2 Psca Lypd1 Alpl Mdga1 Plaur Folr2 Mdga2 Pyurf Nrn1l Gpaa1 Cd109 Otoa Prss21 Prss41 Alppl2 Ntm Xpnpep2 Cntn3 Cntn5 Lypd6b Dpm1 Dpm2 Dpm3 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 96%9726840 SHOC2 M1731 mutant abolishes MRAS complex function Ppp1cc Shoc2 Mras Braf Ywhab Ppp1cb Araf Raf1 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus Neurl1a Dll1 Mib1 Notch3 Ybx1 Mib2 Wwp2 Egfr Ubc Psen1 Egf Psen2 Ncstn Aph1b Dll4 Jag2 Jag1 Adam10 Neurl1b Tacc3 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism Phyh Amacr Acot8 Hsd17b4 Hacl1 Ehhadh Acaa1a Crot Slc27a2 Abcd1 Decr2 Crat Acot4 Acox2 Nudt19 Acox3 Slc25a17 Acbd5 Acbd4 Acoxl Hao2 Nudt7 Pecr PREDNISONE ADME%REACTOME DATABASE ID RELEASE 96%9757110 Prednisone ADME Akr1c21 Serpina6 Cyp3a16 Alb Hsd11b1 Hsd11b2 Ugt1a2 Ugt2b38 Abcb1a DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 96%3560796 Defective PAPSS2 causes SEMD-PA Papss2 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013424 RHOV GTPase cycle Ccp110 Git1 Rhov Pak1 Pak4 Wasl Pak2 Pard6a Cep97 Usp9x Nck2 Map3k11 Nck1 Git2 Sptbn1 Arhgef7 Cltc Txnl1 Peak1 Pak6 Pard6b Arhgap12 Zfp512b Depdc1b Wdr6 Epha2 Sh3rf1 Dlg5 Vangl1 Pik3r1 Tpm3 Myo9a Sptan1 Iqgap1 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs Ipo8 H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 H2bc3 H2bc21 H2bc26 H2ab2 Tnrc6a H2bu2 H2ac12 H2ac11 Ago2 Ago1 H2ac15 Ran H3c7 H2ax Polr2c Polr2d Polr2a Polr2b Polr2g Hist1h2bp Polr2h Hist2h2aa1 Polr2e Polr2f Polr2k H2aj Polr2i Polr2j CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717326 crizotinib-resistant ALK mutants Alk NEPHRIN FAMILY INTERACTIONS%REACTOME%R-HSA-373753.5 Nephrin family interactions Actn2 Kirrel1 Actn1 Kirrel2 Kirrel3 Wasl Nphs1 Actn3 Magi2 Pik3cb Actn4 Nck2 Pik3ca Cask Fyn Nck1 Sptbn1 Pik3r1 Pik3r2 Sptan1 Cd2ap Iqgap1 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.7 Choline catabolism Slc44a1 Slc44a2 Dmgdh Slc22a4 Sardh Aldh7a1 Bhmt Chdh RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 96%5362798 Release of Hh-Np from the secreting cell Notum Gpc5 Disp2 Dhh Ihh Shh Adam17 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 96%72689 Formation of a pool of free 40S subunits Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Eif3m Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Eif3j2 Eif1ax Rps27 Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-5649702.4 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Ogg1 Pnkp Neil1 Polb Xrcc1 Lig3 Neil2 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG Pnpla2 Pnpla3 Mgll Dgat2 Dgat1 Dgat2l6 Awat2 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9024909 BDNF activates NTRK2 (TRKB) signaling Bdnf Ntrk2 FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 96%217271 FMO oxidises nucleophiles Fmo1 Fmo3 Fmo2 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 96%937039 IRAK1 recruits IKK complex Peli3 Peli1 Ube2v1 Ikbkg Irak1 Traf6 Ikbkb Ube2n Chuk Peli2 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling Src Wwp1 Itch Nedd4 Ubc SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 96%9703648 Signaling by FLT3 ITD and TKD mutants Nras Sos1 Stat5a Stat5b Hras Pim1 Gab2 Nox4 Ptpn11 Pik3ca Grb2 Bcl2l1 Cdkn1a Flt3 Pik3r1 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-HSA-110329.4 Cleavage of the damaged pyrimidine H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Tinf2 H2bc3 H2bc21 H2bc26 H2ab2 H3c8 Neil2 Neil3 Nthl1 H2bu2 Ogg1 H2ac12 Neil1 H2ac11 Mbd4 Smug1 Acd H2ac15 H2ax Terf2ip Terf2 Hist1h2bp Terf1 Hist2h2aa1 H2aj Pot1 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%428157 Sphingolipid metabolism Mfsd2b Vapb Sgpl1 Ormdl3 Prkd3 Neu1 Sptssa Sptssb Prkd1 Prkd2 Cers6 St3gal5 Plpp2 Cers5 A4galt Gba2 Plpp3 Cers4 Psap Cers3 Gba1 Plpp1 Hexa Cers2 Hexb Asah2 Sgms1 Sgms2 Sptlc1 Cerk B3gnt5 Sptlc2 Sptlc3 Gm2a Fa2h B3galnt1 Glb1 Sphk2 Kdsr Ugcg Lass1 Smpd4 Glb1l3 Enpp7 Glb1l2 Galc Arsb B4galnt1 Ormdl1 Sphk1 Ugt8 Acer1 Acer2 Gal3st1 Acer3 Ormdl2 Degs2 M6pr Samd8 Ppm1l Osbp Sgpp2 Sgpp1 St6galnac6 Abcg2 Csnk1g2 Abcc1 Aldh3b1 Degs1 B3galt4 Fut2 Fut1 Asah1 Gla Sumf1 Sumf2 Arsa Smpd1 St3gal2 Arsk B4galt5 Arsj B4galt6 Arsi Arsg St6galnac5 Cyb5b Smpd2 Smpd3 Ctsa Vapa St8sia5 Neu2 Neu3 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) Ids DEFECTIVE GALNT3 CAUSES HFTC%REACTOME%R-HSA-5083625.4 Defective GALNT3 causes HFTC Muc6 Muc20 Muc1 Galnt3 Muc15 Muc13 Muc4 METABOLISM OF STEROIDS%REACTOME%R-HSA-8957322.4 Metabolism of steroids Acat2 Sp1 Cyp51a1 Elovl6 Dhcr7 Srebf2 Cyp2r1 Ldlrap1 Fabp6 Lrp2 Cyp39a1 Cyp11b1 Cyp27b1 Cyp46a1 Nr1h4 Akr1c21 Hsd3b7 Alb Cyp27a1 Akr1d1 Cyp7a1 Cyp7b1 Akr1c6 Cubn Amacr Vdr Ppara Fdx1 Hsd17b1 Fdxr Fdx2 Pias4 Acox2 Rxra Cyp19a1 Ube2i Baat Srd5a3 Pomc Osbpl1a Abcc3 Slco1a4 Cyp11a1 Serpina6 Kpnb1 Hsd11b1 Hsd11b2 Akr1b1 Cga Slco1b2 Abcb11 Lhb Srebf1 Acot8 Hsd17b4 Cyp8b1 Stard3nl Stard4 Gc Ran Stard3 Slc27a2 Star Tspo Osbp Ch25h Hsd17b11 Hsd17b14 Osbpl3 Osbpl2 Osbpl7 Srd5a1 Osbpl6 Srd5a2 Osbpl9 Hsd17b2 Cyp17a1 Akr1b8 Cyp24a1 Fasn Slc10a2 Slc10a1 Hsd17b3 Stard5 Slc27a5 Slc51a Slc51b Hsd17b12 Helz2 Carm1 Tbl1x Hsd3b6 Akr1c18 Fdft1 Cyp21a1 Hsd3b1 Insig1 Cyp11b2 Insig2 Ggps1 Sc5d Scd1 Lbr Sar1b Ncoa2 Lss Ncoa1 Tm7sf2 Sec23a Tbl1xr1 Pmvk Smarcd3 Mtf1 Scap Ncoa6 Mvd Acacb Acaca Fdps Lgmn Med1 Idi1 Mvk Nfyb Nfya Nfyc Sec24d Plpp6 Sec24c Hsd17b7 Crebbp Mbtps1 Mbtps2 Nsdhl Dhcr24 Sec24b Sqle Ebp Chd9 Arv1 Sec24a Msmo1 Gpam INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%446652 Interleukin-1 family signaling Ptpn12 Psma4 App Ikbkb Psma3 Il18 Psma6 Psma5 Psma2 Peli1 Psma1 Ikbkg Map3k7 Traf2 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Il1r1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Ctsg Btrc Rbx1 Psma7 Psmc6 Psmc5 Casp8 Psmc2 Psmc1 Casp1 Psmc4 Psmc3 Ubc Gsdmd Psmd7 Psmd6 Il1a Nfkbib Il1b Psmd8 Psmd3 Psmd2 Il1rapl1 Psmd1 Irak1 Nfkbia Adrm1 Sem1 Cul1 Traf6 Ube2n Chuk Ube2v1 Trp53 Tab3 Sigirr Tab2 Il18bp Tab1 Ptpn7 Ptpn9 Smad3 Ptpn2 Ptpn5 Il4 Ptpn18 Il13 Il18r1 Il18rap Ptpn23 Ptpn20 Ptpn13 Ptpn14 Irak3 Il1f10 Map3k3 Il36rn Tifa Alpk1 Il1rl2 Il1rl1 Nfkb2 Il36b Il36a Tollip Il36g Il33 Mapk8 Stat3 Map3k8 Sqstm1 Map2k6 Map2k4 Map2k1 Ptpn6 Il1r2 Il1rn Ptpn11 Ripk2 Tbk1 Myd88 Nkiras1 Nkiras2 Lrrc14 Ikbip Peli2 Peli3 Tnip2 Saa3 Nod2 Nod1 S100b Irak4 N4bp1 Irak2 Ager Nlrx1 Usp14 Alox5 Ptpn4 Usp18 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 96%9634635 Estrogen-stimulated signaling through PRKCZ Mapk1 Nras Pdpk1 Hras Prkcz REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-HSA-191650.4 Regulation of gap junction activity Gja1 Tjp1 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 96%9830674 Formation of the ureteric bud Six2 Gfra1 Wnt11 Pax2 Bmp4 Eya1 Sall1 Slit2 Itgb1 Ret Hoxa11 Hoxd11 Hoxc11 Grem1 Robo2 Six1 Npnt Foxc2 Foxc1 Itga8 Gdnf REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity Plaur Hrg C1qbp F12 Klkb1 Serping1 Krt1 Kng2 A2m REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors Trp73 Trp53 Trp53bp2 Ppp1r13l Ppp1r13b Banp Akt3 Akt2 Pou4f1 Akt1 Pou4f2 Trp63 Phf20 Zfp385a GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 96%157858 Gap junction trafficking and regulation Gja3 Gja5 Gja4 Gja8 Gja1 Gjc2 Gjb2 Gjb4 Gjb3 Gjb6 Gjb5 Dab2 Gjd4 Gjd3 Clta Ap2m1 Cltc Myo6 Cltb Tjp1 Gjd2 Gjc1 Dnm2 Gjb1 Dnm1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK Net1 Arhgef10l Vav2 Prex1 Trio Mcf2 Mapk8 Tiam2 Arhgef15 Arhgef19 Ngef Arhgef9 Bcl2l11 Arhgef7 Arhgef6 Ngfr Arhgef4 Gna13 Fgd2 Rasgrf2 Fgd1 Fgd4 Arhgef37 Fgd3 Arhgef39 Arhgef38 Arhgef40 Plekhg5 Plekhg2 Aatf Ngf Tiam1 Sos1 Abr Arhgef18 Sos2 Mcf2l Arhgef16 Bad Arhgef17 Arhgef11 Arhgef10 Arhgef26 Itsn1 Rac1 Akap13 Kalrn Vav1 Arhgef3 Arhgef2 Arhgef1 Maged1 Ect2 Vav3 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 96%3359474 Defective MMACHC causes MAHCC Mmachc GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking Gja3 Gja5 Gja4 Cltb Gja8 Gja1 Gjc2 Gjb2 Gjb4 Gjb3 Gjb6 Gjb5 Dab2 Gjd4 Gjd2 Gjd3 Gjc1 Dnm2 Gjb1 Clta Ap2m1 Cltc Myo6 Dnm1 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Pabpc1 Rps21 Rpl39l Rps15a Rps27l Etf1 Rplp2 Rps27 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Rps14 Rpl4 Rps16 Ncbp2 Rps18 Ncbp1 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Upf1 Eif4g1 Rpl32 Rps9 Gspt2 Rps7 Gspt1 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 96%9686114 Activation of inflammatory caspases Gsdmd Il1b Serpinb1a Casp3 Casp4 Il18 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 96%190236 Signaling by FGFR Spred1 Spred2 Galnt3 Gipc1 Tgfbr3 Hnrnpf Hnrnpm Hnrnph1 Cbl Polr2c Ubc Polr2d Pik3ca Polr2a Polr2b Mapk1 Fgfbp3 Polr2g Braf Fgfbp1 Polr2h Mapk3 Polr2e Ptbp1 Polr2f Polr2k Polr2i Polr2j Gtf2f2 Klb Gtf2f1 Fgf16 Ppp2cb Frs2 Fgf15 Ppp2ca Fgf18 Fgf2 Fgf1 Nras Fgf4 Gab1 Fgf10 Plcg1 Fgf3 Frs3 Flrt3 Fgf6 Sos1 Fgf7 Fgf9 Hras Fgf20 Ptpn11 Fgf23 Fgfr4 Fgf22 Spry2 Fgfrl1 Ppp2r1a Mknk1 Flrt1 Hnrnpa1 Tial1 Flrt2 Tia1 Esrp2 Rbfox2 Ncbp2 Ncbp1 Pik3r1 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 Pros1 F5 Proc NEF MEDIATED CD8 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%182218 Nef Mediated CD8 Down-regulation Atp6v1h Ap2a2 Ap2s1 Ap2a1 Ap2m1 Cd8b1 Ap2b1 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion Diaph1 Gmpr REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 96%204174 Regulation of pyruvate dehydrogenase (PDH) complex Pdp1 Pdp2 Pdpr Dld Dlat Pdhx Sirt4 Pdha1 Pdha2 Gstz1 Pdk4 Pdk3 Pdk2 Pdk1 Pdhb CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway Prkaca Prkar2b Camkk1 Camkk2 Prkca Prkcg Prkx Prkar1a Prkacb Camk4 Prkar2a Grk2 Pde1b Pde1c Prkcd Adcy3 Pde1a Adcy4 Adcy1 Adcy2 Adcy7 Camk2g Adcy8 Adcy5 Camk2d Adcy6 Camk2b Adcy9 Camk2a Prkar1b SIGNALING BY RAS GAP MUTANTS%REACTOME%R-HSA-9753510.2 Signaling by RAS GAP mutants Kras Nras Hras SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 96%381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Gnat3 Grp Cdx2 Ffar4 Ctnnb1 Pcsk1 Ffar1 Pax6 Gpr119 Gcg Spcs3 Spcs1 Lep Spcs2 Gnb1 Gnb3 Gng13 Tcf7l2 Sec11c Sec11a Dpp4 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease Yes1 Jak2 Lck Nras Sos1 Stat5a Stat5b Hras Pik3ca Fyn Stat3 Stat1 Kit Pik3r1 Pik3r2 Lyn SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 96%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Plxnd1 Dlg4 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Ywhae Btk Dvl1 Dvl2 Cdc25c Dvl3 Lmnb1 Arpc3 Arpc2 Flot2 Flot1 Cyfip2 Rhot2 Arpc5 Arpc4 Rap1gds1 Mfn1 Mfn2 Trak2 Dock7 Mrtfa Senp1 Samm50 Nckipsd Was Wasf3 Mtx1 Wasl Ptpn13 Wwp2 Cdc42bpa Cdc42bpb Rhoj Slc4a7 Fnbp1 Dock8 Fnbp1l Cpne8 Scrib Fmnl3 Nipsnap2 Rasal2 Cul3 Ppp1r12b Ppp1r12a Ppp1r14a Arhgef9 Lin7b Rasgrf2 Pard6b Ccne1 Cdkn1b Abcd3 Clasp1 Clasp2 Pafah1b1 Nup37 Zw10 Farp2 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Tiam1 Sgo1 Ranbp2 Bub1b Kif2a Frs3 Kif2b Kif2c Dync1li2 Dock3 Pmf1 Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Jag1 Ppp2r1b Ppp2r1a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Nuf2 Nup85 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Trak1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Cenpo Cep97 Cenpn Cenpm Srgap1 Mis12 Srgap2 Nup133 Srgap3 Cenpl Arhgap39 Zwilch Cenpk Cenpi Cenph Cenpf Cenpe Dsp Pld2 Slc1a5 Dsg2 Dsg1a Tjp2 Uaca Prkca H2ac20 Ddx4 H2ac12 Cftr H2ac11 H2ac15 Klc1 Klc4 H3c7 Klc3 Klc2 H2ax Myh9 Myl12a Rac1 Hist1h2bp Vav1 H2aj Pik3r1 Pik3r2 Ccp110 Pak1 Pak3 Pak2 H2bc9 H2bc7 H2bc8 H2bc3 Rac2 S100a9 S100a8 H2ab2 H2bu2 Vcp Rab9 Pik3ca Rab9b Hist2h2aa1 Ywhag Kif5b Pdpk1 Men1 Lck H2bc14 Pard6a Rhobtb3 Rhoa Prkcz Arhgef18 Csk Steap3 H2bc21 H2bc26 Abl1 Arl13b Lman1 Mcf2l Rab7 Rhog Arhgdib Arhgdia Garre1 Scai Arhgef16 Shmt2 Arhgdig Arfgap3 Erbin Emd Lemd3 Iqgap2 Lbr Diaph3 Cdc42ep1 Depdc1b Vrk2 Vamp3 Epha2 Dock5 Arhgef26 Itsn1 Arhgap5 Myl12b Itgb1 Dock4 Arhgap1 Kalrn Myh11 Arhgap21 Ropn1 Letm1 Nf2 Prc1 Vangl1 Mcam Flna Ophn1 Stbd1 Ndufa5 Tpm3 Pld1 Dock1 Dock2 Mylk Vapb Elmo2 Myl6 Stx5 Capzb Arhgap32 Gja1 Ykt6 Pak4 Prex1 Arhgap35 Cct6a Trio Mcf2 Esyt1 Tuba1b Plekhg3 Mtmr1 Mpp7 Ktn1 Ankle2 Muc13 Cyfip1 Tmpo Plin3 Cct2 Kdm1a Ppp1cb Actb Ptk2 Cct7 Pfn1 Sptan1 Pfn2 Abl2 Nck2 Nck1 Sptbn1 Evl Rnd3 Ckb Sos2 Sema4f Nisch Aaas Kctd13 Tnfaip1 Pak6 Ckap4 Myo9b Pak5 Sfn Hsp90aa1 Rhou Ptk2b Wdr91 Usp9x Osbpl11 Wdr81 Arhgap4 Arap1 Arhgap9 Arhgap8 Fam91a1 Gmip Cltc Baiap2l2 Golga3 Vma22 Def6 Fgd5 Gopc Lrrc1 Ralgapa1 Wdr11 Arfgap2 Akap12 Tex2 Mospd2 Arhgap12 Arhgap19 Arhgap18 Efhd2 Arhgap22 Arhgap20 Arhgap25 Arhgap24 Arhgap23 Arhgap29 Arhgap28 Zap70 Whamm Arhgap33 Arhgap31 Sh3pxd2a Arhgap30 Dock11 Plekhg6 Plekhg4 Plekhg1 Mtr Ralbp1 Arhgap40 Arhgap44 Arhgap45 Filip1 Hint2 Ankfy1 Faf2 Rhoh Rhof Rhod Rhov Diaph2 Fam13b Shkbp1 Pik3c3 Arhgap11a Emc3 Farp1 Pin1 Kctd3 Cdc42ep2 Cdc42ep5 Cdc42ep3 Cdc42ep4 Syde2 Dnmbp Nsfl1c Rhpn1 Ccdc187 Acbd5 Basp1 Pik3r4 Maco1 Ddrgk1 Ddx39b Spata13 Peak1 Gfod1 Srrm1 Rnd2 Dock6 Als2 Srf Bltp3b Armcx3 Add3 Tor1aip1 Fmnl2 Fmnl1 Cdc42se2 Tmem87a Sh3bp1 Prkcd Zfp512b Prag1 Sh3rf1 Cfl1 Itsn2 Scfd1 Picalm Trip10 Cttn Prkcb Grb7 Vangl2 Aldh3a2 Epsti1 Stip1 Rnd1 Wdr6 Lrrc41 Rras2 Stmn2 Kif14 Ccdc88a Tmem59 Fam83b Ubxn11 Plxna1 Fam135a Cpd Dlg5 Ankrd26 Pkp4 Kdm4c Ywhah Ar Ywhaz Rhob Anln Arhgef17 Slk Arhgef11 Arhgef10 Cavin1 Iqgap3 Diaph1 Daam1 Akap13 Cit Cav1 Arhgef25 Arhgef28 Sowahc Stom Pkn3 Arhgef3 Arhgef2 Arhgef1 Pcdh7 Ect2 Vav3 Myo9a Rtkn Iqgap1 Actc1 Jup Rhpn2 Stk10 Net1 Arhgef10l Vhl Stard8 Vav2 Dlc1 Stard13 Pkn2 Pkn1 Tiam2 Rhoc Plxnb1 Arhgef15 Map3k11 Arhgef19 Ngef Plk1 Dbn1 Spen Twf1 Pde5a Rhot1 Msi2 Arhgef7 Tmod3 Myo6 Arhgef6 Txnl1 Phip Arhgef4 Gna13 Rbmx Fgd2 Actg1 Fgd1 Cops4 Fgd4 Tra2b Cops2 Fgd3 Stk38 Hsp90ab1 Arhgef39 Cpsf7 Arhgef40 Hnrnpc Stam2 Plekhg5 Actn1 Src Plekhg2 Cdc37 Rhobtb2 Rock2 Stam Ctnnb1 Rhobtb1 Rock1 Myh14 Vim Rnf20 Myh10 Hgs Hmox2 Cdh1 Limk1 Limk2 Mapk1 Mapk3 Ywhab Ncf1 Ncf2 Ncf4 Atp6ap1 Brk1 Ocrl Mapk14 Swap70 Amigo2 Noxa1 Frs2 Rac3 Tfrc Git1 Baiap2 Kidins220 Bcap31 Arhgap15 Arhgap17 Nckap1l Fermt2 Bcr Arhgap6 Arap3 Lamtor1 Arap2 Rapgef1 Baiap2l1 Sos1 Arhgap26 Syde1 Abr Mapk11 Nckap1 Slitrk5 Slitrk3 Nhs Git2 Wasf2 Wasf1 Noxo1 Dock10 Racgap1 Taok3 Snap23 Cyba Abi2 Abi1 Cybb Nox3 Arhgap42 Nox1 C1qbp Dbt Ncoa2 Xpo1 Arhgap10 Pgrmc2 Ctnna1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9632700 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Cdkn2a Cdk6 Cdk4 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis Hsd17b11 Hsd17b14 Hsd17b2 Akr1b8 Hsd17b1 Cyp19a1 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9937848 CHD chromatin remodelers Rbm17 Ddx46 Ddx42 Chd1 Adnp2 Adnp Mta1 Mta3 Nr2c2 Dkk2 Cbx3 Chd8 Phf6 Zfp592 Tcf19 Cdk2ap1 Cdk2ap2 Nr2f2 Mbd2 Zmynd8 Ikzf3 Igf2 Znf687 Ikzf2 H2ac20 Ikzf1 Tcf3 Pwwp2a Chd5 Mbd3l1 Zfp827 Hdac1 Pwwp2b Ube2i Chd3 Chd4 H2ac12 H2ac11 H2ac15 H3c7 Phf5a H2ax Axin2 Mta2 Hist1h2bp H2aj Puf60 Chd6 Nqo1 Smndc1 H2bc9 Myog H2bc7 Myod1 H2bc8 H2bc3 Cdc73 Rtf1 Gatad2a Tcf4 Gatad2b Leo1 Skic8 H2ab2 Mbd3 H2bu2 Ctr9 Cbx1 Paf1 Ctnnb1 Tcf12 U2surp Snrpb2 Snrpa1 Hist2h2aa1 Chd2 Wdr5 Nkd2 Fam124b Sf3a1 Chd7 Sf3a2 Sf3a3 G6pc1 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Sf3b5 H2bc14 Sf3b6 Hdac2 Snrpn H2bc21 H2bc26 Cherp Rbbp4 Ctcf Rbbp7 Ep300 Snrpb Snrpd2 Snrpd1 Dhx15 Fbp1 Snrpd3 Mafk Supt16 Nfe2l2 Ssrp1 Crebbp Chd9 Pck1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 96%380284 Loss of proteins required for interphase microtubule organization from the centrosome Prkaca Ccp110 Alms1 Cetn2 Nedd1 Actr1a Tuba1a Cep43 Dctn2 Cep41 Dctn3 Plk1 Ninl Ywhae Cdk1 Nek2 Pcnt Tuba4a Cep250 Sdccag8 Cep78 Cep76 Cep72 Cep70 Tubb5 Plk4 Cpap Clasp1 Ywhag Pafah1b1 Cep135 Cep131 Prkar2b Csnk1e Tubb4b Haus7 Tubb4a Haus8 Cdk5rap2 Cep57 Pcm1 Mapre1 Dynll1 Ssna1 Tubg1 Ppp2r1a Ofd1 Dync1h1 Cep63 Cep152 Haus3 Haus4 Haus5 Haus6 Sfi1 Dync1i2 Csnk1d Haus1 Ckap5 Haus2 Akap9 Hsp90aa1 Cep164 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion Plcb3 Gnaq Plcb2 Plcb1 Gna11 Gna15 Prkca Gna14 Marcks Chrm3 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013700.2 NOTCH4 Activation and Transmission of Signal to the Nucleus Psen2 Ncstn Aph1b Dll4 Notch4 Jag1 Adam10 Ywhaz Psen1 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 96%3595174 Defective CHST14 causes EDS, musculocontractural type Ncan Bgn Cspg5 Cspg4 Dcn Bcan Vcan Chst14 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013418 RHOBTB2 GTPase cycle Hnrnpc Actn1 Cdc37 Rhobtb2 Cct6a Cul3 Dbn1 Twf1 Msi2 Cct2 Tmod3 Myo6 Ddx39b Txnl1 Phip Rbmx Srrm1 Actg1 Hsp90aa1 Cct7 Tra2b Stk38 Hsp90ab1 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 96%9764561 Regulation of CDH1 Function Jup Psma4 Psma3 Psma6 Psma5 Vcl Banp Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Src Ctnnb1 Eps15 Cbll1 Psma7 Psmc6 Psmc5 Psmc2 Ctnnd1 Cdh1 Psmc1 Dnm2 Psmc4 Psmc3 Mdm2 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Mtbp Rack1 Psmd1 Adrm1 Sem1 Ctsb Ctss Ctnna1 VPU MEDIATED DEGRADATION OF CD4%REACTOME%R-HSA-180534.3 Vpu mediated degradation of CD4 Psma4 Psma3 Cd4 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence Cdkn2a Cdk6 Cdk4 NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 96%8956321 Nucleotide salvage Tk2 Uck1 Uck2 Hprt1 Cda Dguok Gmpr Adk Dck Aprt Tymp Adal Gmpr2 Pnp Ampd3 Tk1 Ampd2 Upp1 Ampd1 Upp2 Pudp Ada Uckl1 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer Smad2 Smad3 Tgfb1 Tgfbr1 Tgfbr2 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport Gltp Esyt1 Esyt3 Plekha8 Cptp Esyt2 Arf1 Cln3 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME%R-HSA-5619085.4 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) Slc26a3 ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 96%5662853 Essential pentosuria Dcxr INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1483249 Inositol phosphate metabolism Mtmr7 Plcg2 Nup133 Mtmr9 Ippk Ppip5k1 Ppip5k2 Nudt4 Nudt3 Ip6k1 Nudt11 Ip6k3 Ocrl Nup37 Ipmk Nup160 Minpp1 Nup43 Plcb3 Plcb2 Plcb1 Ranbp2 Plcg1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Inpp5d Plcb4 Aaas Itpka Nup214 Synj1 Inpp5b Nup210 Itpkc Nup155 Itpkb Nup153 Plcz1 Plch2 Plch1 Pld4 Plce1 Plcd1 Pten Plcd4 Plcd3 Itpk1 Inppl1 Nup85 Inpp4a Inpp4b Miox Inpp5a Ip6k2 Impa2 Impa1 Isyna1 Inpp1 Sec13 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders Slc6a5 Slc2a10 Slc16a1 Slc35a2 Slco1b2 Slc24a5 Slc35c1 Slc20a2 Slc24a4 Slc22a12 Slc17a8 Slc29a3 Nup133 Slc35a3 Slc17a5 Avpr2 Avpr1b Slc1a1 Slc5a7 Avpr1a Slc3a1 Avp Slc1a3 Slc40a1 Cp Gck Slc3a2 Slc6a19 Rhag Slc4a1 Slc7a7 Slc22a5 Slc2a9 Slc6a14 Slc36a2 Nup37 Slc7a9 Nup160 Gckr Slc6a20a Slc26a2 Slc11a2 Nup43 Ranbp2 Nup93 Heph Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Hk1 Slc12a1 Tpr Slc24a1 Nup107 Rae1 Ndc1 Nup42 Slc12a3 Nup62 Slc12a6 Nup88 Aaas Nup214 Slc9a9 Nup210 Nup155 Slc9a6 Nup153 Slc2a1 Slc34a1 Slc34a3 Slc34a2 Slc35a1 Slc2a2 Nup85 Slc5a1 Slc6a3 Bsg Slc22a18 Slc4a4 Slc33a1 Slc26a4 Slc26a3 Slco2a1 Sec13 Slc5a5 Slc27a4 Slc39a4 Slc6a2 TICAM1 DEFICIENCY - HSE%REACTOME%R-HSA-5602566.3 TICAM1 deficiency - HSE Ticam1 Tlr3 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 96%3371571 HSF1-dependent transactivation Cryab Akt1s1 Hsbp1 Mlst8 Hspa1l Camk2g Hsf1 Mtor Camk2d Hspa8 Hspb8 Camk2b Dnajb1 Camk2a Rptor Crebbp Hsp90aa1 Ep300 Hspa1a Hspa2 Fkbp4 Hsp90ab1 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 Ngf Hdac3 Ngfr Hdac2 Hdac1 Prdm4 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 96%189445 Porphyrin metabolism Blvra Slco1b2 Fech Uros Ugt1a5 Ppox Cox10 Ugt1a1 Alad Alas1 Hmox2 Alas2 Hmbs Cox15 Cpox Urod Abcc2 Abcg2 Fabp1 Alb Abcc1 Blvrb Hmox1 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism Cacna1d Prkacb Adcy3 Adcy4 Gna11 Adcy1 Gna15 Stxbp1 Adcy2 Gna14 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Gnaq Gnai2 Gnai1 Agpat1 Prkar1b Glp1r Adipor2 Prkar2b Adipor1 Adipoq Mlxipl Plcb3 Plcb2 Plcb1 Gng10 Prkca Gcgr Akap5 Prkaa2 Cd36 Cacna1c Gng3 Gng2 Prkar1a Gng4 Gng7 Gng8 Prkar2a Gngt1 Gngt2 Ahcyl1 Gcg Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Cacna2d2 Gng11 Gng12 Gng13 Cacnb3 Iqgap1 Prkaca Cacnb2 Cacna1e Kcnj11 Cacna1a Itpr3 Itpr2 Itpr1 Tkt Ffar1 Prkag2 Rap1a Adra2a Fasn Marcks Adra2c Chrm3 Ppp2cb Syt5 Ppp2ca Mlx Kcng2 Stk11 Acly Snap25 Pfkfb1 Vamp2 Prkab2 Stx1a Ppp2r1b Ppp2r1a Slc2a1 Kcnb1 Kcns3 Acsl3 Acsl4 Slc2a2 Kcnc2 Acacb Acaca Abcc8 Taldo1 Rapgef4 Ppp2r5d Rapgef3 Ins2 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors Or51a5 Or2z8 Or51d1 Or4x11 Or6a2 Or9g8 Or9g4 Or51b17 Or52e4 Or52e2 Or6b3 Or6b2 Or6b1 Or13c7d Or2t1 Or9a4 Or51f2 Or52h1 Or10p1 Or5h19 Or5h17 Or5h18 Or2t6 Or1s2 Or51e2 Or51e1 Or2v2 Or52j3 Or4d10c Or5ak23 Or10j27 Or51g2 Or2w1 Or2w3 Or8b8 Or51g1 Or52i2 Or8b4 Or8b3 Or10q1 Or5h26 Or5h25 Or4f15 Or13j1 Or10g1b Or8b12i Or4c3 Or3a1 Or4d2 Or4d1 Or5b99 Or6c76 Or6c75 Or6c74 Or4d6 Or4d5 Or10c1 Or11h4 Or4n4b Or7c70 Or2a7 Lhx2 Or10h1b Or2a5 Or10h28 Or5m10 Or11h6 Or7a36 Or11g2 Or2b6 Or2c1 Or6k6 Or10ag2 Or5i1 Or6k2 Or9q2 Or9q1 Or8b12 Or10h5 Or6c6 Or8a1b Or6c3 Or5a1 Or5l14 Or5l13 Or10g3 Or7a41 Or5b3 Or9k2 Or4k15 Or8i2 Or10g9 Or5p80 Or10g7 Or10j5 Or11l3 Or5c1 Or5k16 Or8j3 Or6f1 Or52b2 Or52a20 Or2ag2 Or8k3 Or2ag1 Or8k1 Or52e8b Or52a5 Or8g20 Or10g9b Or51s1 Or2h2 Or9i1b Or2h1 Or6p1 Or4l1 Or4b1d Or8u9 Or4m1 Or13a1 Or4a15 Or8u3 Or5ap2 Or5d43 Or5as1 Or5b107 Or2m13 Or52w1 Or4n5 Or5p6 Or2j3 Or56b1b Or4n4 Or4a47 Or13d1 Or7d11 Or5ar1 Or5b21 Or10ad1c Or51t4 Or2m12 Or13c3 Or1i2 Or2k2 Or6s1 Rtp2 Rtp1 Or5au1 Or4g7 Or1b1 Or2d2 Or5j3 Or13f5 Or4a68 Or6c1b Or5k8 Or2l13 Or5k1 Or11a4 Or8g51 Or6c65 Or14j1 Or1d2 Or2f2 Or2f1 Or6n2 Or6n1 Or6c68 Or13g1 Or1j19 Or5m8 Or5m9 Or5ac16 Or4k2 Or5m3 Or56a5 Or4k5 Or1e1 Or10a3 Or12d17 Ebf1 Or10a4 Or56a4 Or10a5 Or4k1 Or4a79 Or12d12 Or10a2 Ldb1 Or5v1 Or6x1 Or1a1b Or52l1 Or1n1 Or1n2 Or6y1 Or51i2 Or2t44 Or51i1 Or52k2 Or8k16 Or7e178 Or2t45 Or10s1 Or13c25 Or2b11 Or52n4 Or52n5 Or52n2 Or2b2b Or10a3b Or10w1 Or2a25 Or4c106 Or2at4 Or1q1 Or52m1 Or51f1d Or10v1 Or4f58 Or4d10 Or4d11 Or2a12 Or7g19 Or2l5 Or1j4 Or5d18 Or4c29 Or1j1 Or5m10b Or5d16 Or5d14 Or14c46 Or52z13 Or51m1 Or10x1 Or4c15 Or4c11 Or4c12 Or4q3 Or4c10 Or3a1d Or3a1c Or51q1 Or56a3b Or1l8 Or5t9 Or1l4 Or7g34 Or4s2b Or7g33 Or5t5 Or8h10 Or5t17 Or52r1 Or10z1 Or5m11b Or2a57 Or5an1 Or5b12b Or2a56 Or1m1 Reep1 Or52d1 Or1e1c Or14a259 Or14a257 Or51b6 Or51b4 Or2l13b Or10k2 Or8d4 Or8d6 Or2y1 Or8d1 Or51a7 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C Hgsnat NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-HSA-5654732.3 Negative regulation of FGFR3 signaling Fgf16 Ppp2cb Frs2 Ppp2ca Fgf18 Fgf2 Fgf1 Fgf4 Cbl Fgf9 Fgf20 Ubc Ptpn11 Fgf23 Mapk1 Braf Mapk3 Spry2 Ppp2r1a Mknk1 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-HSA-110357.3 Displacement of DNA glycosylase by APEX1 Nthl1 Ogg1 Mbd4 Smug1 Apex1 Mpg DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 96%9675135 Diseases of DNA repair Topbp1 Rpa2 Rad17 Rbbp8 Brca2 Brca1 Rad51ap1 Xrcc2 Rpa3 Rad1 Atm Kat5 Exo1 Nbn Msh6 Msh2 Rfc5 Msh3 Pms2 Mlh1 Neil3 Rfc3 Nthl1 Ogg1 Rfc4 Neil1 Rfc2 Hus1 Atrip Brip1 Dna2 Rad51c Rad51d Blm Rad51b Rad9a Bard1 Rad9b Top3a Wrn Mre11a Palb2 Sem1 Rad51 Rad50 Rpa1 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%561048 Organic anion transport by SLC22 transporters Slc22a6 Slc22a12 Slc22a8 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 96%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) Slco1b2 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 96%909733 Interferon alpha beta signaling Adar Oas3 Irf8 Samhd1 Irf6 Irf9 Ifit3b Tyk2 Irf7 Abce1 Isg15 Ifnar1 Stat1 Socs1 Stat2 Irf2 H2-Q10 Irf5 Oas2 Gbp2 Ubc Ifnb1 Psmb8 Socs3 Irf1 Ptpn6 Irf4 Ptpn11 Ifi35 H2-M5 H2-M3 Irf3 Ifi27 Kpna1 Ifit2 Oas1g Egr1 H2-Q1 Rnasel Rsad2 Bst2 Ifit1bl2 Ifitm2 Ifitm3 Usp18 Eif2ak2 Ptpn1 Ip6k2 Jak1 Kpnb1 Oasl1 Isg20 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 Neil1 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME%R-HSA-5624138.4 Trafficking of myristoylated proteins to the cilium Rp2 Arl3 Unc119b Cys1 Nphp3 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes Prss2 Ctrb1 Amn Abcd4 Cblif Lmbrd1 Cubn TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%6784531 tRNA processing in the nucleus Cpsf4 Nup133 Elac2 Rpp40 Trnt1 Clp1 Cpsf1 Cstf2 Ran Rpp14 Nup37 Nup160 Pop7 Pop5 Nup43 Pop4 Pop1 Fam98b Zbtb8os Ranbp2 Tsen34 AI597479 Rtraf Nup93 Xpot Nup50 Rtcb Nup35 Tsen15 Nup54 Ddx1 Pom121 Tsen54 Nup205 Tsen2 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Nup85 Rpp38 Rpp30 Rpp21 Sec13 Rpp25 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation Peli3 Peli1 Ube2v1 Ikbkg Irak1 Traf6 Ikbkb Ube2n Chuk Peli2 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) Slc39a4 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 96%5654228 Phospholipase C-mediated cascade; FGFR4 Fgf16 Fgf15 Fgf18 Fgf2 Fgf1 Fgf4 Plcg1 Fgf6 Fgf9 Fgf20 Fgf23 Fgfr4 Klb DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) Slc7a7 Slc3a2 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%450302 activated TAK1 mediates p38 MAPK activation Ube2v1 Tab3 Nod2 Map2k3 Tab2 Nod1 Tab1 Irak2 Mapk11 Ripk2 Ikbkg Map3k7 Irak1 Mapkapk3 Mapkapk2 Traf6 Mapk14 Ube2n Map2k6 TCR SIGNALING%REACTOME DATABASE ID RELEASE 96%202403 TCR signaling Cd3g Cd3e Cd3d Pak1 Pak3 Pak2 Psma4 Ikbkb Grap2 Psma3 Psma6 Plcg2 Psma5 Psma2 Trat1 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Malt1 Ube2d1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Card11 Btrc Ptprj Psma7 Psmc6 Psmc5 Psmc2 Pik3cb Psmc1 Zap70 Psmc4 Itk Psmc3 Ubc Fyb1 Cd101 Bcl10 Pik3ca Lcp2 Psmd7 Psmd6 Lat Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Pdpk1 Adrm1 Pag1 Sem1 Traf6 Cul1 Ube2n Prkcq Was Chuk Cdc34 Vasp Ube2v1 Lck Tab2 Plcg1 H2-Eb1 Cd4 Nck1 Ripk2 Csk Ptpn22 Evl Inpp5d Pten Ptprc Pik3r1 Pik3r2 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371599 Defective HLCS causes multiple carboxylase deficiency Acaca Mccc1 Pcx Pcca Mccc2 Pccb Hlcs APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 96%176409 APC C:Cdc20 mediated degradation of mitotic proteins Psma4 Psma3 Psma6 Psma5 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdk1 Cdc27 Ube2d1 Psmb5 Cdc16 Nek2 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Ccna1 Psmd7 Ccna2 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cdc20 Mad2l1 Bub1b Pttg1 Bub3 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-HSA-1660662.8 Glycosphingolipid metabolism Neu1 St3gal5 A4galt Gba2 Psap Gba1 Hexa Hexb Asah2 Cerk B3gnt5 Gm2a B3galnt1 Glb1 Ugcg Smpd4 Glb1l3 Enpp7 Glb1l2 Galc Arsb B4galnt1 Ugt8 Gal3st1 M6pr St6galnac6 B3galt4 Fut2 Fut1 Asah1 Gla Sumf1 Sumf2 Arsa Smpd1 St3gal2 Arsk B4galt5 Arsj B4galt6 Arsi Arsg St6galnac5 Smpd2 Smpd3 Ctsa St8sia5 Neu2 Neu3 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 96%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome Slc25a15 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 96%9945266 Differentiation of T cells Gata3 Nfatc1 Il12rb2 Stat6 Nfatc2 Batf Ets1 Pou2f2 Il5 Stat5a Stat5b Jun Ncor2 Gatad2a Gatad2b Mbd3 Yy1 Pou2f1 Ring1 Runx3 Cbx8 Phc2 Cbx6 Phc1 Mamld1 Cbx4 Mta1 Cbx2 Notch1 Mta3 Phc3 Kat2b Maf Kat2a Bmi1 Dpy30 Wdr5 Tpst2 Men1 Rnf2 Satb1 Tnf Ifng Il4 Il13 Irf4 Hdac2 Hdac1 Hdac5 Hdac4 Tbx21 Hdac7 Hdac6 Rbbp5 Hdac9 Rbbp4 Hdac8 Ncor1 Rbbp7 Smarca4 Ep300 Tbl1x Chd3 Chd4 Notch2 Hdac3 Tbl1xr1 Il4ra Ash2l Maml1 Mta2 Maml2 Hdac11 Hdac10 Fos Rbpj Stat4 Klf13 Crebbp PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage Tk2 Dck Uck1 Tymp Uck2 Tk1 Upp1 Upp2 Pudp Uckl1 Cda PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME%R-HSA-167290.4 Pausing and recovery of HIV elongation Supt5h Ell Nelfa Nelfb Nelfe Ctdp1 Ccnk Polr2c Polr2d Polr2a Polr2b Supt4h1a Polr2g Tcea1 Polr2h Nelfcd Polr2e Supt16 Polr2f Cdk9 Polr2k Ccnt2 Ssrp1 Polr2i Ccnt1 Polr2j Eloa Gtf2f2 Eloc Gtf2f1 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 96%114294 Activation, translocation and oligomerization of BAX Bax Bid DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME DATABASE ID RELEASE 96%9846298 Defective binding of VWF variant to GPIb:IX:V Vwf Gp9 Gp1bb Gp5 Gp1ba EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin Hbegf Nras Prkca Mmp3 Sos1 Hras Egfr COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-HSA-6807878.2 COPI-mediated anterograde transport Arfgap1 Kdelr2 Stx5 Capzb Gbf1 Ykt6 Capza1 Capza2 Nsf Actr1a Copz2 Copz1 Dctn2 Arf5 Golga2 Dctn3 Arf1 Arfgap2 Arcn1 Tmem115 Spta1 Rab1a Sptb Rab1b Tmed9 Bet1l Gosr2 Cd59b Tmed3 Uso1 Copg1 Copg2 Cog1 Ank3 Kdelr1 Cog2 Ank1 Copb2 Cog3 Cog4 Cog6 Gorasp1 Cog7 Golgb1 Cog8 Sptan1 Folr1 Copb1 Napa Napb Bet1 Napg Arf4 Dync1li2 Dync1li1 Sptbn1 Actr10 Sptbn2 Dctn5 Dynll1 Dctn6 Dctn1 Dynll2 Dctn4 Capza3 Sptbn4 Copa Arfgap3 Dync1h1 Kdelr3 Arf3 Cope Gosr1 Dync1i2 Dync1i1 Ins2 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 96%4086400 PCP CE pathway Psma4 Prkcg Psma3 Psma6 Psma5 Rac2 Psma2 Psma1 Clta Ap2m1 Psmd12 Cltc Psmd11 Psmd14 Psmd13 Smurf2 Smurf1 Dvl1 Dvl2 Psmb5 Dvl3 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Ap2a2 Psmb2 Cltb Ap2a1 Prkcb Vangl2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ap2b1 Ubc Wnt5a Psmd7 Ap2s1 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Pfn1 Rac3 Wnt11 Ryk Prkca Pard6a Rhoa Prickle1 Wnt1 Wnt4 Fzd1 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Scrib Fzd8 Daam1 Rac1 Wnt5b Ror1 Ror2 Arrb2 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME%R-HSA-4755579.4 Defective SRD5A3 causes CDG-1q and KHRZ Srd5a3 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase Cacnb1 Cacnb2 Cacng8 Cacng4 Cacng7 Kcne5 Cacng6 Kcne4 Cacna1c Kcne3 Kcne2 Kcne1 Akap9 Cacna2d2 Kcnq1 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Ell Nelfa Nelfb Nelfe Ctdp1 Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Polr2b Supt4h1a Polr2g Tcea1 Polr2h Nelfcd Polr2e Supt16 Polr2f Cdk9 Polr2k Mnat1 Ssrp1 Polr2i Ccnt1 Polr2j Gtf2h2 Eloa Gtf2h1 Gtf2f2 Gtf2h4 Eloc Gtf2f1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%450341 Activation of the AP-1 family of transcription factors Mapk1 Fos Mapk3 Mapk10 Atf2 Mapk9 Mapk8 Mapk14 Jun Mapk11 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855196 IP3 and IP4 transport between cytosol and nucleus Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Nup85 Nup37 Sec13 Nup160 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) Slc24a1 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 96%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) Slc9a6 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-HSA-2187335.6 The retinoid cycle in cones (daylight vision) Opn1sw Rlbp1 Dhrs3 Rbp3 Opn1mw Awat2 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d Alg3 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619229 Activation of RAC1 downstream of NMDARs Git1 Rac1 Camkk1 Camkk2 Camk1 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 96%1236978 Cross-presentation of soluble exogenous antigens (endosomes) Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Mrc1 Psmc2 Psmc1 Psme2 Psmc4 Psme1 Psmc3 Psmb10 Fcgr1 Psmd7 Psmd6 Psmd8 Psmd3 Psmb9 Psmd2 Psmb8 Psmd1 Mrc2 Adrm1 Sem1 Cd207 HIV TRANSCRIPTION INITIATION%REACTOME%R-HSA-167161.4 HIV Transcription Initiation Gtf2h3 Taf4 Taf3 Gtf2h5 Taf2 Ercc2 Taf1 Ccnh Ercc3 Cdk7 Taf15 Taf11 Taf13 Taf12 Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Polr2c Taf9 Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Taf8 Gtf2h2 Gtf2h1 Taf7 Gtf2f2 Taf6 Gtf2h4 Gtf2f1 Taf5 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2468052 Establishment of Sister Chromatid Cohesion Pds5b Pds5a Esco1 Esco2 Smc1a Rad21 Smc3 Stag2 Stag1 Cdca5 Wapl GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation Prkaca Prkar2b Gng10 Gcgr Gng3 Gng2 Prkar1a Gng4 Gng7 Gng8 Prkacb Prkar2a Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Gcg Adcy9 Gnb2 Gnb1 Gnb4 Gnb3 Gng11 Gng12 Prkar1b Gng13 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%435354 Zinc transporters Slc39a8 Slc30a5 Slc39a7 Slc39a6 Slc39a5 Slc30a3 Slc30a2 Slc30a8 Slc30a1 Slc39a14 Slc39a3 Slc39a10 Slc39a4 Slc39a2 Slc39a1 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia Ugt1a1 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 96%167238 Pausing and recovery of Tat-mediated HIV elongation Supt5h Ell Nelfa Nelfb Nelfe Ctdp1 Polr2c Polr2d Polr2a Polr2b Supt4h1a Polr2g Tcea1 Polr2h Nelfcd Polr2e Supt16 Polr2f Cdk9 Polr2k Ssrp1 Polr2i Ccnt1 Polr2j Eloa Gtf2f2 Eloc Gtf2f1 FLT3 SIGNALING IN DISEASE%REACTOME DATABASE ID RELEASE 96%9682385 FLT3 signaling in disease Flt3l Trip11 Nras Cbl Myo18a Sos1 Stat5a Etv6 Stat5b Hras Pim1 Gab2 Zmym2 Ubc Nox4 Ptpn11 Pik3ca Grb2 Bcl2l1 Cdkn1a Sptbn1 Flt3 Pik3r1 Golgb1 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 96%389359 CD28 dependent Vav1 pathway Fyn Cd86 Cd80 Rac1 Pak1 Lck Vav1 Pak3 Pak2 Cd28 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events Adora2b Grk3 Prkacb Avpr2 Avp Adcy3 Adcy4 Adcy1 Sct Adcy2 Adcy7 Adm Adcy8 Adcyap1 Adcy5 Ramp1 Adcy6 Gnaz Adcy9 Iapp Crhr1 Gnai2 Gnai1 Gipr Gnai3 Gip Calcrl Prkar1b Glp1r Crh Pth1r Gnat3 Prkar2b Cysltr2 Calcr Ghrhr Gng10 Pth Gcgr Pth2 Glp2r Vipr2 Calca Ppan Vipr1 Gng3 Gng2 Prkar1a Gng4 Mc1r Gng7 Ghrh Mc5r Gng8 Adora2a Pth2r Pthlh Prkar2a Rln3 Rxfp2 Rxfp1 Mc4r Rln1 Pomc Gngt1 Insl3 Nps Gngt2 Gpbar1 Npsr1 Gcg Mc3r Adcyap1r1 Ptger4 Ptger2 Ramp3 Ramp2 Gnb2 Adm2 Gnb1 Gnb4 Gpha2 Gnb3 Gnb5 Gng11 Cga Vip Gng12 Gng13 Tshb Arrb2 Prkaca Arrb1 Lhcgr Grk5 Ptgdr Lhb Src Gpr15 Gpr25 Fshb Gpr27 Mc2r Gpr20 Fshr Gpr45 Gpr84 Gpr83 Pde10a Pde11a Gpr176 Gpr150 Pde7b Pde7a Crhr2 Pde8a Pde8b Htr4 Grk6 Htr6 Pde3a Htr7 Pde2a Pde4a Hrh2 Pde4c Pde4d Drd1 Adrb2 Itga5 Adrb1 Drd5 Adrb3 Taar8b Taar6 Pde3b Gper1 Taar9 Taar2 Taar5 Taar1 Grk2 Ptgir Pde1b Tshr Pde1a Itgb1 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 96%5693607 Processing of DNA double-strand break ends Rnf4 Topbp1 Rpa2 Rad17 Rbbp8 Brca1 H2bc9 Rpa3 H2bc7 H2bc8 Rad1 Atm H2bc3 H3c8 H2bu2 Ubc Cdk2 Ccna1 Ccna2 Ube2n Ube2v2 H2bc14 Pias4 Ube2i H2bc21 Ppp4r2 H2bc26 Timeless Kat5 Tipin Exo1 Ppp4c Clspn Trp53bp1 Abraxas1 Nbn Brcc3 Rfc5 Rnf168 Nsd2 Rfc3 Babam1 Sirt6 Babam2 Rfc4 Uimc1 Mdc1 Rfc2 Hus1 Atrip Brip1 H2ax Dna2 Blm Chek1 Hist1h2bp Rad9a Bard1 Rad9b Top3a Wrn Mre11a Herc2 Rad50 Rpa1 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades Tlr4 Fgb Fga Fgg Ikbkb S100a1 S100a9 Cd36 S100a8 Myd88 Tirap Traf3 Ikbkg Ticam1 Tlr1 Cd14 Btk Tlr6 Tlr2 Nfkb1 Tlr5 Rela Irak4 Nfkb2 Unc93b1 Tlr7 Tlr3 Ly96 Nfkbia Chuk AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 96%71291 Amino acid and derivative metabolism Rimkla Rimklb Amt Crym Psat1 Srm Srr Tmlhe Kynu Qdpr Pah Asrgl1 Pcbd1 Kyat1 Il4i1 Hgd Tat Fah Hpd Slc44a1 Slc44a2 Trp53 Ckb Gstz1 Glyat Slc6a11 Rps14 Rpl4 Rps16 Glul Rps18 Rps19 Rpsa Rpl37 Rpl39 Mpst Rps10 Sqor Mri1 Rps11 Suox Rpl7 Ado Txn2 Mtap Rpl32 Bhmt Csad Rps9 Rps7 Cbs Bhmt2 Rps5 Tstd1 Rpl24 Rpl26 Got1 Rpl22 Got2 Rpl23 Ethe1 Fmo1 Nqo1 Apip Enoph1 Rps25 Adi1 Rps26 Tst Cth Gadl1 Rps21 Cdo1 Slc25a10 Rpl39l Rps15a Rps27l Rplp2 Rpl22l1 Carnmt1 Hal Rplp1 Ddc Pnmt Aoc1 Rpl13a Th Rpl18a Uroc1 Hdc Dbh Rpl17 Amdhd1 Naalad2 Rpl18 Carns1 Aspg Rpl19 Aspa Ftcd Hnmt Nat8l Rpl10l Rpl11 Glud1 Rps3 Rps4x Sirt5 Papss2 Papss1 Acat1 Slc45a2 Slc6a7 Oca2 Ahcy Nnmt Dct Tyrp1 Mtrr Ogdh Tyr Dlst Mtr Hibch Mccc1 Auh Ivd Mccc2 Mat1a Ppm1k Shmt1 Rida Sds Sdsl Rps27 Hsd17b10 Psma4 Psma3 Aanat Tph2 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Tph1 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Slc36a4 Psmc1 Psmc4 Slc3a2 Psmc3 Slc25a12 Slc25a13 Psmd7 Psmd6 Psmd8 Slc7a5 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Slc6a12 Lars1 Phykpl Eef1e1 Paox Crat Kars1 Txnrd1 Asns Pipox Pxmp2 Ddo Mars1 Hao1 Aldh4a1 Prodh Agxt Prodh2 Dars1 Qars1 Dao Rars1 Aimp2 Aimp1 Eprs1 Iars1 Gamt Duox1 Gls Duoxa1 Duoxa2 Gpt Cav1 Dio1 Txndc11 Dio2 Dio3 Duox2 Tpo Dmgdh Iyd Slc22a4 Cga Sardh Slc5a5 Aldh7a1 Chdh Tshb Aldh6a1 Bcat1 Bcat2 Acad8 Hibadh Slc25a44 Acadsb Echs1 Gcsh Inmt Eefsec Gnmt Scly Sars1 Slc25a15 Sepsecs Arg1 Sephs2 Secisbp2 Nags Asl Pstk Ckmt1 Cps1 Ckmt2 Nmral1 Tdo2 Ass1 Afmid Otc Hoga1 Agxt2 Ido2 Acmsd Ido1 Pycr3 Pycr2 Pycr1 Kyat3 Oaz1 Oaz3 Oaz2 Dhtkd1 Bckdhb Gldc Bckdk Hykk Bckdha Phgdh Dbt Aadat Dld Agmat Slc25a21 Gcdh Slc6a8 Arg2 Aass Oat Odc1 Gatm Bbox1 Gls2 Ckm Slc25a2 Aldh9a1 Sat1 Serinc4 Serinc5 Serinc2 Serinc3 Serinc1 Haao Kmo Grhpr Azin2 Psph Azin1 RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription Runx3 Bcl2l11 Smad3 Smad4 Foxo3 SIGNALING BY WNT IN CANCER%REACTOME%R-HSA-4791275.5 Signaling by WNT in cancer Lrp6 Ppp2cb Lrp5 Ppp2ca Gsk3b Csnk1a1 Porcn Tnks2 Ppp2r5e Tnks Wnt3a Tcf7l2 Ppp2r1b Apc Ppp2r1a Ctnnb1 Fzd5 Fzd4 Fzd6 Fzd8 Dkk1 Dkk2 Dkk4 Rnf43 Kremen2 Kremen1 Ctbp1 Ppp2r5d Ctbp2 Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Axin1 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3311021 SMAD4 MH2 Domain Mutants in Cancer Smad2 Smad3 Smad4 HCMV INFECTION%REACTOME DATABASE ID RELEASE 96%9609646 HCMV Infection H2bc9 H2bc7 H2bc8 H2bc3 Nup133 Elk1 Chmp2a Ncor2 Hnrnpk Nfkb1 Chmp3 Chmp7 Chmp6 H2bu2 Cbx1 Chmp4c Gps2 Chmp4b H2bc18 Egfr Daxx Hist2h2aa1 Nup37 Nup160 Eed Nup43 Ranbp2 H2bc14 Nup93 H2ac20 Nup50 Nup35 Dync1li2 Nup54 Pom121 Nup205 Dync1li1 Nup188 Tpr H2bc21 Nup107 Rae1 Ndc1 H2bc26 Nup42 Nup62 Rbbp4 Nup88 Ncor1 Dynll1 Rbbp7 Chmp1a Trim28 Dynll2 Aaas Nup214 Nup210 Nup155 Nup153 Tbl1x Cebpd H2ac12 H2ac11 Vps36 Dync1h1 Hdac3 Ubap1 Tsg101 H2ac15 H2ac21 Mvb12a H3c7 Mvb12b Ezh2 H2ac25 Vps37a Tbl1xr1 Vps37b Hist1h2af Nup85 Vps37c Suz12 Vps37d H2ac1 Snf8 Vps25 Dync1i2 Vps28 Itgb1 Dync1i1 Hist1h2bp Vps4a Pml Sec13 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660499 Synthesis of PIPs at the plasma membrane Mtmr2 Pip4k2b Inpp5k Mtm1 Pip4k2a Pik3c2b Bmx Pik3c2g Mtmr3 Mtmr1 Ptpn13 Pik3c2a Mtmr6 Pip5k1b Mtmr9 Pip5k1a Synj2 Inpp5d Rab4a Synj1 Arf1 Pten Rab5a Inppl1 Pip5k1c Pik3cg Pi4k2a Pik3cb Sbf2 Pik3cd Plekha8 Plekha6 Plekha5 Inpp4a Pik3ca Inpp4b Plekha3 Plekha2 Plekha1 Pik3r5 Mtmr14 Pik3r6 Rab14 Pik3r1 Ocrl Pik3r2 Rufy1 Pi4k2b REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation Topbp1 Taf4 Rpa2 Taf3 Rad17 Taf2 Rbbp8 Taf1 Nuak1 Brca1 Rpa3 Plk3 Rad1 Tpx2 Atm Cdk5r1 Cdk5 Chek2 Hipk1 Hipk2 Prkag3 Prkag1 Prkag2 Mdm2 Ubc Cdk2 Mdm4 Ccna1 Ccna2 Trp53rkb Mapk14 Csnk2b Trp53 Mapkapk5 Pin1 Mapk11 Prkaa1 Stk11 Prkaa2 Dyrk2 Trp53inp1 Kat5 Exo1 Aurka Nbn Rfc5 Prkab2 Prkab1 Rfc3 Rfc4 Taf15 Taf11 Rfc2 Taf13 Taf12 Hus1 Tbp Atrip Taf4b Brip1 Dna2 Csnk2a2 Blm Taf9 Chek1 Rad9a Aurkb Bard1 Rad9b Supt16 Top3a Wrn Ssrp1 Mre11a Taf8 Taf7 Rad50 Taf6 Rpa1 Taf5 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling Tfrc Atp6v1a Atp6v1b2 Mcoln1 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Atp6v1h Steap3 Atp6v0b Hfe Atp6v0a2 Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Tf Tfr2 Atp6ap1 Atp6v1e2 Atp6v1e1 Steap4 Tcirg1 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols Cyp51a1 Fdx1 Fdxr Fdx2 Rxra Cyp19a1 Cyp1b1 Ahr Arnt Ahrr Cyp21a1 Pomc Cyp11b2 Cyp8b1 Ncoa2 Cyp4v3 Ncoa1 Cyp39a1 Cyp11b1 Cyp46a1 Cyp11a1 Nr1h4 Cyp27a1 Cyp7a1 Cyp7b1 G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 Mybl2 Hdac1 Myc Cdc6 Rbl2 Rbbp4 Rbl1 Dyrk1a Cdk1 Cdc25a Pcna Ccne1 Ccne2 Tfdp2 Tfdp1 E2f4 E2f5 Cdk2 E2f1 Ccna1 Ccna2 Max Lin54 Lin9 Lin37 Top2a SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 96%9006927 Signaling by Non-Receptor Tyrosine Kinases Nrg3 Nr3c1 Elmo2 Sfpq Rasa1 Pxn Arhgap35 Nras Khdrbs1 Khdrbs3 Khdrbs2 Crk Hras Rhoa Pelp1 Egf Bcar1 Arap1 Ereg Stat3 Hbegf Akt1 Btc Hif1a Ccne1 Nrg1 Stap2 Cbl Ccnd1 Gpnmb Cdk4 Ubc Lrrk2 Egfr Cdk2 Erbb2 Ptk6 Rac1 Ptpn1 Srms Cdkn1b Elmo1 Socs3 Epas1 Dok1 Dock1 Nrg2 Nrg4 DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 96%5579004 Defective CYP26C1 causes FFDD4 Cyp26c1 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME DATABASE ID RELEASE 96%9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB Golga4 Kank1 Etv6 Bin2 Kdr ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 96%901032 ER Quality Control Compartment (ERQC) Sel1l Edem2 Rnf5 Syvn1 Ubc Rnf103 Amfr Rnf139 Man1b1 Marchf6 Trim13 Uggt1 Edem1 Uggt2 Os9 Edem3 Rnf185 Derl2 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%5663202 Diseases of signal transduction by growth factor receptors and second messengers Fkbp1a Porcn Tyk2 Wdcp Jun Bcl2l11 Foxo3 Gzmb Notch1 Rbx1 Ihh Shh Dhh Tnks2 Tnks Fgfr1 Wdr48 Wnt3a Casp9 Bad Fzd5 Fzd4 Fzd6 Camk2g Fzd8 Camk2d Camk2b Camk2a Spred1 Spred3 Spred2 Mapk9 Nf1 Mapk8 Nrg1 Papss1 Rb1 Mdm2 Zmym2 Cdkn1a Cdkn1b Flt3 Cebpb Ppp2cb Ppp2ca Clip1 Ranbp2 Bdnf Gab1 Plcg1 Frs3 Ntf4 Ntrk2 Irf4 Ntf3 Egf Bcl2l1 Areg Eef1g Dll4 Jag2 Jag1 Adam10 Neurl1b Ppp2r1b Ppp2r1a Adam17 Neurl1a Dll1 Mib1 Dusp7 Dusp6 Mprip Ap3b1 Kiaa1549 Tent4a Ppp2r5d Akap9 Ppp2r5c Snd1 Ppp2r5b Lmna Trak1 Ppp2r5a Agtrap Trim24 Fam114a2 Fxr1 Kdm7a Ppp1cc Zc3hav1 Clcn6 Agk Aggf1 Qki Fam131b Ppp2r5e Flt3l Dkk1 Dkk2 Polr2c Dkk4 Polr2d Rnf43 Polr2a Polr2b Kremen2 Polr2g Kremen1 Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Nrg2 Nrg4 Gtf2f1 Nrg3 Lrp6 Lrp5 Gsk3a Fgfr3 Syvn1 Bcl2a1d Myc Akt3 Hip1 Akt2 Alk Akt1 Eml4 Bcl11a Erlin2 Ppm1b Prkar1a Eif2ak3 Strn Birc6 Tcf7l2 Lyn Mov10 Yes1 Ago4 Ago3 Ago2 Ago1 Klc1 Il10 Myo18a Cux1 Myh9 Fgfr1op2 Cpsf6 Cd28 Erbb2 Rac1 Vav1 Os9 Pik3r5 Pik3r6 Pik3r1 Pik3r2 Axin1 Sel1l Trip11 Cep43 Mib2 Rac2 Trat1 Pdgfrb Pik3ap1 Stat3 Junb Ntrk3 Stat1 Rictor Derl2 Cd86 Cd80 Vcp Golga4 Pik3cg Pik3cb Pik3cd Kat2b Pik3ca Gcc2 Kat2a Erlec1 Prr5 Hhat Kif5b Pdpk1 Gsk3b Lck Mlst8 Csnk1a1 Ptpn6 Mtor Ptpn11 Fyn Csk Tnrc6c Mapkap1 Rhog Cdk8 Erbin Ncbp2 Ncbp1 Tpm3 Ptpn12 Stat5a Stat5b Pim1 Nox4 Grb2 Atic Ppp1cb Kank1 Esr2 Ppfibp1 Trp53 Bag4 Msn Tpr Itga2b Sptbn1 Hes1 Fgfr2 Mcl1 Twist1 Il22b Maml1 Maml2 Hdac11 Hdac10 Rbpj Hsp90aa1 Hey2 Hey1 Tgfb1 Ncor2 Ereg Hbegf Cltc Btc Epgn Sqstm1 Mamld1 Zap70 Egfr Rps6kb2 Amer1 Klb Fgf16 Fgf15 Irs1 Shoc2 Fgf18 Mras Irs2 Fgf2 Fgf1 Fgf4 Il10ra Fgf10 Fgf3 Fgf6 Fgf7 Fgf9 Fgf20 Hdac2 Hdac5 Gab2 Fgf23 Fgfr4 Fgf22 Hdac7 Hdac6 Hdac9 Hdac8 Cars1 Pdgfb Pten Rnf213 Atg7 Ccnc Cd19 Psma4 Foxo4 Psma3 Psma6 Foxo1 Fn1 Psma5 Psma2 Tgfa Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Tfg Psmb5 Psmb4 Nr4a1 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Sec31a Npm1 Psma7 Psmc6 Lmo7 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Golgb1 Cul1 Chuk Dusp10 Dusp9 Dusp8 Smad2 Smad3 Smad4 Esr1 Mark3 Hdac1 Hdac4 Dctn1 Kit Kras Brap Phb1 Apbb1ip Arrb2 Iqgap1 Arrb1 Jak2 Fgb Fga Rap1b Ksr1 Vwf Cnksr2 Cnksr1 Fgg Araf Itgb3 Pebp1 Raf1 Tln1 Map3k11 Vcl Src Cdc37 Ctnnb1 Cbl Dusp16 Fip1l1 Etv6 Bin2 Rrbp1 Met Kdr Hgf Shc1 Mapk1 Braf Mapk3 Ctbp1 Ctbp2 Ywhab Tgfbr1 Tgfbr2 Rap1a Frs2 Akt1s1 Map2k2 Bcr Nras Map2k1 Sos1 Hras Tsc2 Prf1 Foxm1 Zc3hc1 Icos Ncor1 Ep300 Apc Tbl1x Hdac3 Dnmt1 Pdgfra Tbl1xr1 Psen1 Psen2 Ncstn Aph1b Heyl Hes5 Crebbp INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA Igf2bp1 Igf2bp3 Igf2bp2 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375281 Hormone ligand-binding receptors Lhb Tshr Gpha2 Gnrh1 Gnrhr Lhcgr Cga Fshb Tshb Fshr NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669926 Nilotinib-resistant KIT mutants Kit GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 96%6814848 Glycerophospholipid catabolism Pnpla6 Enpp6 Pnpla7 Gdpd5 Gde1 Gdpd3 Gdpd1 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription Maml1 Notch2 Gzmb Maml2 Hes5 Mamld1 Rbpj Hes1 Ep300 Fcer2a PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%169893 Prolonged ERK activation events Frs2 Ngf Kidins220 Map2k2 Ntrk1 Map2k1 Rapgef1 Crk Mapk1 Braf Mapk3 Crkl Ywhab Rap1a DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME%R-HSA-5619068.5 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) Slc2a10 RHOC GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013106 RHOC GTPase cycle Vapb Jup Stx5 Arhgap32 Stk10 Arhgef10l Vav2 Prex1 Arhgap35 Dlc1 Stard13 Mcf2 Pkn2 Pkn1 Rhoc Tmpo Arhgap39 Arhgef40 Flot2 Flot1 Arhgap18 Rock2 Rock1 Tjp2 Abcd3 Tfrc Bcr Arhgap26 Rhoa Abr Ccdc187 Acbd5 Maco1 Racgap1 Lman1 Mcf2l Myo9b Arhgdia Fmnl2 Erbin C1qbp Lbr Diaph3 Anln Arhgef17 Depdc1b Slk Arhgef11 Vamp3 Arhgef10 Cavin1 Iqgap3 Fmnl3 Diaph1 Daam1 Arhgap5 Akap13 Cit Cav1 Arhgef25 Arhgap1 Arhgef28 Arhgap21 Stom Vangl1 Pkn3 Mcam Ophn1 Pik3r1 Arhgef1 Iqgap1 Rtkn DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function Rbbp8 Brca2 Brca1 Rad51ap1 Brip1 Xrcc2 Dna2 Rad51c Rad51d Atm Blm Rad51b Bard1 Top3a Kat5 Exo1 Wrn Mre11a Nbn Sem1 Palb2 Rad51 Rad50 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation Arrb1 Fgb Fga Rap1b Map2k2 Ksr1 Vwf Cnksr2 Nras Cnksr1 Fgg Map2k1 Araf Mark3 Lamtor2 Itgb3 Pebp1 Raf1 Hras Tln1 Fn1 Vcl Csk Itga2b Src Mapk1 Braf Mapk3 Ywhab Rap1a Il17rd Apbb1ip Wdr83 Arrb2 Iqgap1 MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206290 MPS IV - Morquio syndrome A Galns AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769743.1 Amplification and propagation of coagulation cascade Ano6 F2 Vwf F5 F8 F9 Gp1ba Serpina5 Serpine2 Pros1 Gp9 Gp1bb Gp5 F10 Proc Serpinc1 Serpind1 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 96%9605310 Defective Base Excision Repair Associated with MUTYH DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Egf CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase Anapc15 Fzr1 Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Cdc14a Ube2e1 Cdc23 Cdc20 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family Slc30a5 Slc30a3 Slc30a2 Slc30a8 Slc30a1 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation Tnrc6c Ago4 Ago3 Pten Ago2 Ago1 Tnrc6a Tnrc6b Mov10 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 96%74749 Signal attenuation Shc1 Irs1 Insr Mapk1 Irs2 Grb10 Mapk3 Ins2 Sos1 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 96%4549349 Defective ALG2 causes CDG-1i Alg2 RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696270 RND2 GTPase cycle Frs2 Tfrc Kidins220 Plxnd1 Arhgap35 Frs3 Ptpn13 Ktn1 Muc13 Golga3 Txnl1 Rbmx Nisch Rnd2 Kctd13 Tnfaip1 Lrrc1 Ckap4 Bltp3b Nudc Lemd3 Vangl2 Prag1 Aldh3a2 Depdc1b Fnbp1 Wdr6 Dsg1a Epha2 Scrib Kif14 Arhgap5 Fam83b Cav1 Ubxn11 Arhgap1 Dlg5 Vangl1 Ankrd26 Pkp4 Pik3r1 Pik3r2 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin Lep Jak2 Irs1 Stat3 Irs2 Socs3 Stat5a Stat5b Ptpn11 ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-HSA-418990.6 Adherens junctions interactions Sp1 Arhgap32 Tyk2 Banp Birc2 Angptl4 Ang Xiap Kdm1a Zfp217 Ank3 Pomt1 Pomt2 Tgif2 Klf9 Strap Foxj2 Foxp2 Twist2 Twist1 Cdh4 Cdh15 Nectin1 Nectin2 Nectin3 Nectin4 Il6 Canx Rb1 Arid1a Dnm2 Kmt5a Mdm2 Zmym2 Cadm3 Cadm2 Cadm1 Mtbp Rack1 Foxq1 Il6st Wt1 Zc3h12a Farp2 Cdh9 Cdh7 Cdh6 Cdh5 Cdh3 Tle1 Pcsk7 Tiam1 Cdh19 Cdh17 Pkm Cdh13 Foxa2 Cdh12 Cdh10 Zbtb33 Hdac2 Mphosph8 Mcrip1 Smarca4 Il6ra Zeb2 Ctsb Ctss Hace1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rela Psma7 Psmc6 Pip5k1c Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Ganab Cdh2 Mogs Rnf19b H2ac20 Zeb1 Tcf3 Hdac1 Myc Prkcsh Traf7 Rpn2 Rpn1 Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 Sox10 H3c7 Ezh2 H2ax Snai2 Csnk2a2 Suz12 Rac1 Hist1h2bp Jak1 H2aj Jup Jak2 Vav2 H2bc9 H2bc7 H2bc8 H2bc3 Vcl Stat3 Tmem258 Arhgef4 H2ab2 Mycn Sec11c Sec11a H2bu2 Stt3a Src Ctnnb1 Eps15 Cbll1 Ostc Tcf12 Ctnnd1 Cdh1 Mapk1 Mapk3 Hist2h2aa1 Furin Ctbp1 Ctbp2 Pcsk6 Dad1 Ddost Csnk2b Eed H2bc14 Tfap2a H2bc21 Tnrc6c H2bc26 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Spcs3 Spcs1 Hoxc8 Spcs2 Heyl Cdh8 Adam19 Adam33 Cdh24 Elmo1 Ctnna1 Snai1 Klf4 Prdm8 Ilf3 Foxf1 Bhlhe22 Cdh11 Sirt1 Dock1 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Ywhah Ccna1 Chek1 Ccna2 Sfn Ywhae Wee1 Ywhab Chek2 Ywhag Cdk1 Cdc25c Ywhaz PTK6 REGULATES CELL CYCLE%REACTOME%R-HSA-8849470.2 PTK6 Regulates Cell Cycle Ptk6 Ccne1 Cdkn1b Ccnd1 Cdk4 Cdk2 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-HSA-3249367.2 STAT6-mediated induction of chemokines Tbk1 Stat6 Sting1 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking Kdelr2 Copz2 App Copz1 Arf5 Golga2 Chmp2a Actr2 Arpc1a Ap2m1 Actr3 Ldlrap1 Ywhae Galnt2 Chmp3 Dvl2 Chmp7 Chmp6 Myo5a Arpc3 Arpc2 Ap2a2 Ap2a1 Arpc5 Arpc4 Ldlr Chmp4c Tmem115 Chmp4b Tmed9 Ap2b1 Wnt5a Ap2s1 Tmed3 Copg1 Copg2 Copb2 Myo1c Copb1 Sbf1 Wasl Synj1 Gns Fzd4 Fnbp1 Fnbp1l Cyth2 Cyth3 Golga5 Cyth4 Cyth1 Golim4 Snap29 C2cd5 Slc2a4 Tbc1d1 Rab10 Rab13 Tbc1d4 Rab14 Ralgapb Aspscr1 Kif18b Use1 Kif26b Kifc2 Kif12 Nsf Kif21a Kif1c Kif21b Kif13b Kif1a Kif1b Bnip1 Gria1 Kif6 Kif9 Stx18 Kif27 Rint1 Kif16b Kif20b Kif19a Surf4 Pafah1b1 Zw10 Rab27a Kif2a Kif2b Kif2c Dync1li2 Egf Dync1li1 Areg Dynll1 Dynll2 Kif18a Dync1h1 Dync1i2 Dync1i1 Ap3b1 Sec13 Actr1a Mia3 Dctn2 Dctn3 Rab11a Rabgef1 Gga2 Gga1 Exoc3 Cenpe Rab4a Exoc4 Optn Gga3 Exoc5 Rabgap1 Tbc1d14 Exoc6 Tbc1d13 Exoc1 Tbc1d16 Exoc2 Tbc1d15 Rab11b Avpr2 Rab33b Exoc7 Rab33a Exoc8 Tbc1d17 Rabep1 Tbc1d2 Avp Rab35 Tbc1d7 Gabarapl2 Tbc1d10c Tjp1 Rab8b Tbc1d10b Tbc1d10a Ulk1 Sytl1 Tbc1d25 Gabarap Tbc1d24 Kif3a Kif3b Agpat3 Kif3c Pla2g6 Galnt1 Man2a1 Arf4 Prkaa2 Akt3 Hip1 Akt2 Akt1 Kif26a Kif11 Kif15 Cftr Kif22 Kif23 Vps36 Kif20a Ubap1 Klc1 Tsg101 Klc4 Mvb12a Rab3ip Klc3 Mvb12b Klc2 Vps37a Vps37b Cux1 Myh9 Vps37c Vta1 Vps37d Snf8 Vps25 Csnk1d Chmp5 Vps28 Rac1 Vps4a Vps4b Kifap3 Cd3g Cd3d Gbf1 Trip11 Rab8a Chm Rab5a Rab9 Golga4 Rab5c Prkag3 Rab43 Rab5b Tmf1 Golga1 Vps51 Prkag1 Vps52 Prkag2 Cops5 Vps53 Vps54 Arl1 Gcc2 Gcc1 Rab9b Cog1 Usp6nl Cog2 Stx6 Cog3 Ywhag Cog4 Kif5b Cog6 Cog7 Cog8 Igf2r Napa Napb Ric1 Scoc Naa35 Vti1a Naa38 Napg Rab6b Vamp4 Rab6a Rgp1 Naa30 Stx16 Arfip2 Rhobtb3 Cd4 Rabepk Arfrp1 Lman1 Rab7 Prkab2 Prkab1 Arfgap3 Arf3 Sbf2 Vamp3 Itsn1 Ins2 Stx4 Stx5 Capzb Gja1 Ykt6 Gjb2 Capza1 Capza2 Plin3 Spta1 Sptb Ank3 Ank1 Dnm1 Kif4 Sptan1 Dnm3 Agtr1a Sptbn1 Sptbn2 Sptbn4 Slc18a3 Gjd2 Gjc1 Sfn Tacr1 Rab3a Clta Ereg Hbegf Cltc Btc Epgn Cops3 Cops6 Arf1 Arfgap2 Dnajc6 Clvs1 Clvs2 Cops8 Dnase2a Cltb Cops7a Ctsz Vamp7 Cops7b Bloc1s1 Vamp8 Ap4s1 M6pr Txndc5 Ap1g2 Ap4m1 Dnm2 Hspa8 Gjb1 Egfr Ap4e1 Gja3 Gja5 Gja4 Gja8 Gjc2 Gjb4 Gjb3 Gjb6 Gjb5 Gjd4 Gjd3 Stxbp3 Als2 Pla2g4a Grk2 Man1a Man1a2 Rab27b Man1c1 Als2cl Gdi1 Gdi2 Rab3il1 Dennd4c Dennd4a Dennd4b Rab39b Lnpep Rab31 Rab32 Trappc8 Rab39 Rab38 Fcho1 Fcho2 Dennd5a Rab3gap1 D130043K22Rik Dennd1a Tor1a Arfgap1 Dennd5b Dennd1b Tor1b Dennd1c Necap2 Necap1 Rin3 Scarb2 Rin1 Sgip1 Rin2 Bin1 Rab21 Itsn2 Chml Hip1r Mon1b Dab2 Dennd6a Mon1a Agfg1 Dennd6b Grk3 Snx9 Dennd2a Amph Dennd2b Snap91 Dennd2c Pik3c2a Dennd2d Hps1 Syt9 Rab12 Tgfa Syt8 Aak1 Rab18 Hps4 Synj2 Ctsc Trappc12 Scfd1 Gapvd1 Trappc11 Picalm Ppp6r1 Trappc13 Snx18 Ppp6r3 Lman2 Syt11 Rinl Slc2a8 Ankrd27 Sec22c Sec22b Ubqln2 Dennd3 Sec22a Epn2 Tfg Ubqln1 Preb Epn1 Trappc6b Ap1m2 Gak Ap1m1 Ppp6c Il7r Arf6 Trappc9 Ap1s3 Trappc6a Lrp2 Ap1s2 Ston2 Trappc5 Eps15l1 Trappc4 Ap1b1 Ap1s1 Sec31b Pacsin1 Trip10 Trappc3 Ap1g1 Sec31a Cttn Trappc2 Pacsin3 Trappc1 Pacsin2 F5 Reps2 F8 Pip5k1c Rab1a Stx17 Rab1b Trappc2l Gosr2 Ubc Lman1l Tbc1d20 Cd59b Uso1 Sec23ip Trappc10 Map1lc3b Sec16b Cpd Sec16a Mcfd2 Lman2l Serpina1d Cnih1 Tbc1d8b Sh3d19 Gorasp1 Golgb1 Cnih3 Ap3s1 Cnih2 Tpd52l1 Folr1 Dtnbp1 Ankrd28 Bet1 Yipf6 Snapin Snx2 Snx5 Bloc1s3 Bloc1s4 Bloc1s6 Acbd3 Pum1 Sort1 Ywhah Pafah1b3 Pafah1b2 Actr10 Dctn5 Dctn6 Dctn1 Dctn4 Capza3 Bicd2 Bicd1 Ywhaz Kdelr3 Arrb2 Arrb1 Vps45 Clint1 Myo6 Cops4 Cops2 Arcn1 Stam2 Sh3gl3 Rab30 Sh3kbp1 Stam Rab36 Eps15 Cbl Hgs Bet1l Sh3gl1 Sh3gl2 Tf Ftl1 Fth1 Kdelr1 Ywhab Ocrl Rala Chrm2 Tfrc Adrb2 Tsc2 Nedd8 Tsc1 Alppl2 Syt2 Racgap1 Syt1 Snap23 Vamp2 Copa Sar1b Sec23a Cope Gosr1 Sec24d Sec24c Col7a1 Sec24b Sec24a Apob DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 96%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 Dpagt1 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 96%5654736 Signaling by FGFR1 Ppp2cb Frs2 Ppp2ca Fgf18 Spred1 Fgf2 Spred2 Fgf1 Nras Fgf4 Gab1 Fgf10 Plcg1 Fgf3 Frs3 Flrt3 Fgf6 Sos1 Gipc1 Fgf9 Hras Fgf20 Ptpn11 Fgf23 Tgfbr3 Fgf22 Spry2 Ppp2r1a Mknk1 Fgfrl1 Flrt1 Flrt2 Cbl Ubc Pik3ca Mapk1 Braf Mapk3 Pik3r1 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways Sp1 Smad3 Smad4 Psmc6 Ywhah Ube2i Cav1 Sfn Ywhae Ywhab Ywhag Pdpk1 Ep300 Ywhaz SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane Mtmr2 Mtmr9 Mtm1 Pik3r4 Pik3c3 Pikfyve Fig4 Vac14 Mtmr4 Mtmr7 Pik3c2a RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013405 RHOD GTPase cycle Vapb Capzb Arhgap32 Arhgap35 Esyt1 Plxnb1 Dbn1 Tmpo Arhgap39 Lmnb1 Akap12 Mospd2 Actn1 Arhgap12 Efhd2 Whamm Plxna1 Filip1 Hint2 Ankfy1 Rhod Arhgap17 Arhgap26 Steap3 Racgap1 Lman1 Rab7 Pak6 Pak5 Add3 Tor1aip1 Emd Lemd3 Lbr Diaph3 Slc4a7 Depdc1b Vrk2 Vamp3 Cpne8 Diaph1 Arhgap5 Cav1 Arhgap1 Pgrmc2 Arhgap21 Vangl1 Mcam Pik3r1 Stbd1 Pik3r2 ABACAVIR ADME%REACTOME DATABASE ID RELEASE 96%2161522 Abacavir ADME Adal Nt5c2 Abcg2 Slc22a2 Slc22a3 Slc22a1 Pck1 Abcb1a GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK Cckbr Nras Mapk7 Prkca Sos1 Hras Egfr Gast Mapk1 Hbegf Mapk3 Rps6ka3 Rps6ka1 Mmp3 Rps6ka2 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428559 Proton-coupled neutral amino acid transporters Slc36a2 Slc36a1 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951911.2 RUNX3 regulates RUNX1-mediated transcription Runx3 Cbfb SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer Egf Tgfa Ereg Areg Hbegf Btc Epgn Egfr FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 96%9758920 Formation of lateral plate mesoderm Gata4 Foxf1 Ihh Bmp4 Shh MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) Hyal1 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy Vps16 Vps41 Map1lc3b Vps45 Uvrag Vps33a Vps33b Vps39 Tufm Vps18 Vps11 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates Ltc4s Gstm4 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling Apoc2 Apoe Lipg Alb Apoc3 Apoa1 Abcg1 Lcat AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 Atp6v0b Fnip1 Samtor Szt2 Atp6v1g3 Itfg2 Nprl3 Atp6v0e2 Nprl2 Wdr59 Mios Atp6v1c2 Depdc5 Atp6v1c1 Kptn Castor1 Kics2 Wdr24 Flcn Sh3bp4 Rptor Atp6v1e2 Atp6v1e1 Tcirg1 Slc38a9 Atp6v1a Lamtor5 Atp6v1b2 Atp6v0d2 Lamtor4 Atp6v0d1 Rraga Mlst8 Atp6v1b1 Rragb Sesn2 Atp6v0e1 Atp6v1g2 Lamtor1 Atp6v1g1 Rragc Lamtor2 Rragd Atp6v1f Mtor Atp6v1d Atp6v1h Sesn1 Sec13 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%416700 Other semaphorin interactions Plxnd1 Tyrobp Ptprc Plxnc1 Sema6d Sema6a Trem2 Sema4d Sema4a Sema7a Itgb1 Sema3e Plxna1 Plxna4 Cd72 Plxnb3 Sema5a Plxna2 Itga1 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9915355 Beta-ketothiolase deficiency Acat1 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%168256 Immune System Pdcd4 Pitpna Il12rb1 Il12rb2 Il27 Il27ra Crlf1 Cnn2 Il3ra Il2rb Csf2rb2 Csf2ra Il5 Il5ra Cyb5r3 Ap2m1 Prkacb Mylip Ap2a2 Npc2 Ap2a1 Ap2b1 Ap2s1 P4hb A2m Idh1 P2rx1 Il4 Il13 Il18rap Brwd1 Tslp Crlf2 Il7 Rag2 Rag1 Gns B4galt1 Plac8 Sdc1 Manba Rab10 Pgam1 Rab14 Gaa Man2b1 Dera Aldoc Aldoa Il34 Ptprz1 Il16 Prtn3 Txlna Ifnlr1 Stx3 Aoc1 Cd44 Pygb Agl Pygl Gyg1 Itgax Itgam Itgb7 Itgb2 Icam5 Icam4 Cd47 Hpse Hk3 Pgm2 Pgm1 Tkfc Taldo1 Mmp2 Pfkl Galns Traf3 Ticam2 Ticam1 Cd14 Ikbke Tank Optn Flt3l Commd9 Aprt Pnp Ampd3 Commd3 Socs5 Socs6 Maoa Ppm1b Eif2ak3 Il9 Il9r Armc8 Trat1 Pik3ap1 Sh2b3 Tec Ttr H2az1 Tspan14 Cst3 Prss2 Art1 Mme Kif5b Atp6ap2 Anpep Rhoa Cd180 Ly86 Lbp Cd209a Bpi Relb Rps6ka5 Icam2 Rab7 Rhog Iqgap2 Vamp3 Itgb1 Stbd1 Pld1 Dock1 Dock2 Elmo2 Cyfip1 Fabp5 Dgat1 Itgav Ptk2 Anxa2 Il1rapl1 Vasp Abl2 Cul2 Nck1 Cap1 Evl Sos2 Ckap4 Myo9b Il17rb Il17re Cntf Cntfr Il1f10 Clcf1 Ctf1 Fscn1 Map3k3 Il36rn Ndn Mcl1 Mmp1a Il4ra Il15ra Il1rl2 Il1rl1 Il21r Il22b Il36b Il36a Ctsa Il20rb Il20ra Il31ra Tollip Il36g Il11 Il15 Il19 Il22ra2 Osmr Rhou Il33 Il21 Il20 Il25 Il24 Neu1 Osm Il17c Il22ra1 Batf Il13ra1 Il13ra2 Ptk2b Ifnl3 Elk1 Arhgap9 Sqstm1 Arf1 Mospd2 Ctsz Vamp7 Vamp8 Txndc5 Dnm2 Hspa8 Gsto1 Arhgap45 Faf2 Rhof Irs1 Irs2 Fgf2 Pik3c3 Gab2 Tlr9 Pik3r4 Csf3r Il6ra Lrr1 Nedd4 Rnf220 Fbxl20 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb Sh3rf1 Trim11 Ube2l6 Gdi2 Mex3c Rnf126 Dcaf1 Rnf123 Ubac1 Rab31 Lnpep Atg7 Rnf114 Rnf115 Hace1 Siah2 Keap1 Kbtbd13 Dzip3 Mkrn1 Ube2g2 Ube2g1 Rnf138 Rnf130 Kbtbd8 Gan Fbxw8 Anapc13 Det1 Klhl9 Rbck1 Arih2 Rlim Klhl2 Ube4a Spsb2 Rab18 Trim9 Spsb1 Trip12 Spsb4 Lrsam1 Huwe1 Ube2j2 Ube2j1 Socs1 Kctd7 Ube2w Ube2m Ube2k Rnf182 Ube2o Ltn1 Ube2h Mgrn1 Ube2f Ube2a Fbxo10 Fbxo11 Fbxo17 Lmo7 Rnf41 Ube3d Ube3c Lrrc41 Klhl13 Ube2z Klhl11 Ube3b Ube3a Traip Fbxo21 Ubox5 Fbxo22 Ubr1 Rnf19a Ubr2 Glmn Ubr4 Fbxo27 Ube2v2 Uba5 Uba6 Uba7 Trim69 Trim71 Klhl25 Ube2e3 Ube2e2 Btbd6 Rnf19b Klhl21 Klhl22 Klhl20 Alad Fbxl8 Fbxo30 Fbxo31 Fbxl4 Fbxl7 Lonrf1 Zbtb16 Uba1 Uba3 Tpp2 Cul5 Pafah1b2 Actr10 Cul7 Fbxo41 Dctn5 Traf7 Dctn6 Hectd1 Dctn4 Fbxo44 Capza3 Hectd2 Hectd3 Thop1 Znrf1 Trim50 Dtx3l Rap1gap Blmh Rnf14 Klhl41 Tyrobp Klhl42 Ptprc Ufl1 Fbxo40 Npepps Ube2q2 Trem2 Ube2q1 Btbd1 Pja2 Pja1 Arel1 Rnf144b Fbxo2 Asb12 Asb11 Siah1a Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc2 Herc3 Ube2r2 Herc1 Rnf6 Rnf7 Rnf4 Fbxo7 Herc6 Fbxo9 Trim21 Vhl Fbxl12 Fbxl13 Fbxl14 Fbxl15 Fbxl16 Trim39 Fbxl18 Fbxl19 Trim37 Trim36 Trim32 Trim41 Asb9 Asb8 Asb7 Asb6 Asb5 Rnf25 Asb4 Asb3 Asb2 Rchy1 Asb1 Lnx1 Chrnb4 Hgf Ncf1 Ncf2 Ncf4 Brk1 Baiap2 Nckap1l Nckap1 Wasf2 Wasf1 Racgap1 Snap23 Cyba Abi2 Abi1 Cybb C1qbp Slc2a5 Psen1 Ncstn Elmo1 Hck Cd8b1 C3ar1 Plcg2 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Btk Myo5a Arpc3 Arpc2 Nlrp3 Pstpip1 Cyfip2 Arpc5 Arpc4 Ctsg Fcgr1 Fcgr3 Fcgr4 Syk Mefv Fgr Myh2 Myo1c Nckipsd Was Wasf3 Pycard Wasl Sugt1 P2rx7 Myo10 Frk Il2rg Inpp5d Pld4 Inppl1 Hvcn1 Ripk2 Myd88 Acly Nkiras1 Nkiras2 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Peli2 Peli3 Tlr5 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Usp18 Fuca2 Actr1a Bpifb2 Dctn2 Dctn3 Tubb5 Kif3a Kif3b Kif3c Gab3 Sipa1 Rap1gap2 Nos3 Cd74 Ctse Ctsf Actr1b Ctsh Kif26a Ctso Kif11 Kif15 Lag3 H2-DMa H2-Ob Kif22 Kif23 H2-Oa Rilp Kif20a Osbpl1a Klc1 Klc4 Klc3 Klc2 H2-DMb2 Kifap3 Polr3gl Crcp Polr3a Polr3d Polr3e Polr1c Polr3b Polr3c Polr3h Polr3f Polr1d Polr3g Polr3k Gpr84 Rab9b Igf2r Rab6a Dus2 Nf2 Flna Stat5a Cda Stat5b Pim1 Grb2 Ctsd Pou2f1 Dnm1 Kif4 Sptan1 Dnm3 Nfasc Ncam1 Msn Sptbn2 Tax1bp1 Rab3a Dnajc5 Eif4a2 Cd177 Eif4a1 Clec7a Clec10a Clec4n Prkcd Clec4a2 Clec4d Clec4e Clec4b2 Card9 Ctsb Ctss Unc93b1 Lgmn Hsp90b1 Tlr8 Tlr7 Tlr3 Fcn2 Crp Cfd C1qb C1qa C1rb Gzmm Colec10 C1s2 Colec11 Mbl2 C1qc Grb10 Stat6 Cgas Sting1 Trim56 Aim2 Ddx41 Irf7 Psma4 Dhx9 Ikbkb Prkdc Psma3 Trex1 Psma6 Dhx36 Psma5 Xrcc6 Psma2 Xrcc5 Psma1 Nlrc3 Ikbkg Ctsc Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Sec22b Skp1 Malt1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Sec31a Card11 Prkcb Btrc Trappc1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Bcl10 Psmd7 Cd59b Psmd6 Nfkbib Ppl Nfkbie Psmd8 Psmd3 Psmd2 Psmd1 Serpina1d Nfkbia Adrm1 Sem1 Cul1 Rel Chuk Dsc1 Rora Ube2i Pias1 Prkce Diaph1 Vapa Stom Mre11a Jup Stk10 Atg5 Atg12 Anapc5 Anapc4 Fuca1 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdk1 Cdc27 Ube2d1 Cdc16 Ube2e1 Cdc23 Src Sh3kbp1 Rab37 Ctnnb1 Acaa1a Slc27a2 Cbl Rab4b Cdh1 Sh3gl2 Bin2 Rab3d Shc1 Mapk1 Mapk3 Crkl Ywhab Rab24 Mapk12 Rap1a Mapkapk3 Mapk13 Mapkapk2 Mapk14 Rala Nras Map2k1 Rapgef1 Sos1 Crk Hras Mapk11 Arg1 Mlec Atf2 Ep300 Hmox1 Hbbt1 Nfe2l2 Ly96 Ilf3 Crebbp Mef2c Otud5 Apob Tlr4 Fkbp1a Nfatc1 Nfatc3 Ppia Nfatc2 Rasgrp3 Rasgrp1 Jak3 Ppp3r1 Ppp3ca Ppp3cb Tyk2 Blnk App Jun Cd79a Cd79b Capn1 Ifnar1 Sod2 Ifngr2 Ifngr1 Bcl2l11 S1pr1 Fasl Fnta Fntb Stat2 Il1r1 Foxo3 Lmnb1 Slc44a2 Rbx1 Bst1 Copb1 Plaur Gsn Adgre5 Cpne1 Cpne3 Colec12 Casp9 Snap29 Mtap Kbtbd7 Hp Cul3 Abce1 Hexb Surf4 Glb1 Arsb Gusb Tasl Rbsn Fzr1 Eea1 Irf5 Skp2 Mrc1 Ccnd1 Btn1a1 Btnl9 Cdk4 Btn2a2 Btnl2 Cd300a Hspa5 Pros1 Cdkn1a Cdkn1b Flt3 Alox15 Nup37 Nup160 Pdxk Cdc20 Ppp2cb Ppp2ca Nup43 Rab27a Ranbp2 Kif2a Kif2b Kif2c Irf4 Dync1li2 Naprt Dync1li1 Nup107 Dsn1 Atp8a1 Dynll1 Dynll2 Ppp2r1b Atp11b Ppp2r1a Atp11a Kif18a Dync1h1 Birc5 Nup85 Dync1i2 Dync1i1 Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Atp7a Sec13 Cd22 Ano6 Plau Cenps Serpinb6a Ppp2r5e Txk Nup133 Cenpe Prl Apeh Dsp Pld2 Casp3 Pkp1 Dsg1a Polr2h Polr2e Polr2f Lpcat1 Polr2k Mmp25 Agpat2 Asah1 Zeb1 H2ac20 H2-Eb1 Trib3 Prkaa1 Prkaa2 Myc Akt3 Akt2 Akt1 Erlin2 Erlin1 Atf3 Adam8 Jund Mmp8 Rpn2 Rpn1 Hif1a Tcf7l1 Tcf7l2 Lyn Mov10 Yes1 H2ac12 H2ac11 Lamp2 Ago4 Cxadr Ago3 Ago2 Ago1 Jaml H2ac15 H3c7 Mt2 Ezh2 H2ax Sell B3gnt3 Csnk2a2 Sirpa Tead4 Suz12 Cd28 Nfkb2 Ccr5 Olr1 Ash2l Rac1 Hist1h2bp Jak1 Fos Vav1 Trem1 H2aj Os9 Pik3r5 Pik3r6 Pik3r1 Pik3r2 Yap1 Tnfrsf14 Ctla4 Sirpb1b Cd3g Cd3e Cd3d Pak1 Sel1l Fosb Magt1 Pak3 Pak2 Brd4 H2bc9 H2bc7 H2bc8 Grap2 H2bc3 Cd300lb Mib2 Cd300lg Cd300lf Tead3 Rac2 Tead2 S100a9 Cd226 Npdc1 Tead1 S100a8 Stat3 Cd40lg Tmem258 Mill2 Stat1 Hcst Map3k14 Klrk1 Klrg1 Rictor H2ab2 Siglec1 Klrc1 Map3k8 Clec4g Rnf185 Mycn Lair1 Derl3 Ncr1 Pianp Nek2 Derl2 Klrb1 Derl1 Lilra5 Ifih1 H2bu2 Sike1 Cd300e Cd86 Cd1d2 Rnf135 Cd80 Cd96 Trim25 Stt3a Mavs Treml2 Sh2d1a Stt3b Rigi Spop Treml4 Treml1 Vcp Cd300c2 Tcf7 Klrd1 Ostc Rab5c Siglec12 Prkag3 Rab5b Pik3cg Cd200 Cd160 Pik3cb Crtam Pik3cd Oscar Prkag1 Ca1 Prkag2 Cd200r1 Fcgr2b Cops5 Slamf6 Pik3ca Wwtr1 Sh2d1b1 Cd8a Tusc3 Slamf7 Kmt2c Btla Pilra Pilrb Hist2h2aa1 Erlec1 Siglecg Prr5 Dad1 Ywhag Pdpk1 Pag1 Epas1 Dpy30 Wdr5 Ddost Csnk2b Eed Them4 Cd274 Gsk3b Lck Irf1 Mlst8 Icosl Lef1 H2bc14 Ptpn6 Pdcd1 Rnf5 Mtor Cd4 Ptpn11 Fyn Csk H2bc21 Tnrc6c H2bc26 Rbbp5 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Pdcd1lg2 Mapkap1 Prkab2 Prkab1 Kcnab2 Eloc Itgb5 Ndufc2 Anxa1 Ptpn12 Muc15 Muc13 Cct2 Fbxw10 Actb Fbxw4 Fbxw5 Fbxw7 Fbxw9 Sphk1 Tcp1 Cfp Fbxw2 Muc1 Srp14 Fbxo4 Muc4 Muc6 Fbxo6 Muc20 Slco4c1 Cct8 Trp53 Mgst1 Fbxl3 Fbxl5 Tubb4b Fpr2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Kpna1 Aaas Nup214 Nup210 Nup155 Nup153 F2 Ptafr Panx1 Eif2ak2 Slc11a1 Kpnb1 Hsp90aa1 Tgfb1 Kpna4 Kpna7 Kng2 Kpna3 Isg15 Dnajc3 Fcer1a Clta Ms4a2 Cltc Calr Mmp3 Hspa1a Nlrp1a Canx Blk Zap70 Itk Fyb1 Pdzd11 Cd101 Lcp2 Lat Lat2 Vnn1 Slc15a4 Hgsnat Thoc5 Arsa Dhx58 Rnf216 Tnfsf13 Eif4a3 Mmtag2 Cr2 Padi2 Serping1 Nbeal2 Cfh Sox2 Prdx4 C5ar2 Pgrmc1 Cfi C5ar1 Cystm1 Flg2 Clu Ptprn2 C6 C7 Pa2g4 S100a11 C9 Cd46 Rnase2a Cfhr1 Rnase2b Cfhr2 Clec12a Prkra Cd81 Tmt1a C8b Syngr1 Tarbp2 C8a Glipr1 Tmc6 Cpn1 Cpn2 Pglyrp1 C8g Ptges2 Cd19 Grn Cpb2 Enpp4 Ypel5 Nfam1 Aga Trpc1 Pigr Crispld2 Ormdl3 Lrg1 Plekho2 Adgrg3 Epx Kcmf1 Serpinb1a Serpinb12 Trpm2 Bri3 Serpinb3d Ptprb Ghdc Lamp1 Arl8a Nit2 Fn1 Chi3l1 Lama5 Acp3 Vtn Crisp1 Olfm4 Atad3a Fgl2 Dnase1l1 Gm2a Slpi Nhlrc3 Mcemp1 Scamp1 Krt1 Ap1m2 Prcp Ap1m1 Tmem179b Il7r Cant1 Unc13d Ap1s3 Calm4 Ap1s2 Ap1b1 Tmem30a Vat1 Ap1s1 Ap1g1 Prg3 Prg2 B2m H2-Q10 Rap2b Rap2c Ptprj Camp Abca13 Cd53 Psme2 Stk11ip Psme1 Irag2 Cstb Gca Rnaset2a Psmb10 Erp44 Creg1 Mpo Cd68 Dok3 Becn1 Hebp2 Psmb9 Cd93 Psmb8 Cotl1 Dpp7 Aldh3b1 Tarm1 Traf6 Cenpx Degs1 Ube2n Tmbim1 Cracr2a Prkcq Cpped1 Rasgrp4 Rasgrp2 Mvp Ms4a3 Cdc34 Pdap1 Ube2v1 Tab3 Tmem63a Tab2 Cmtm6 Tab1 Tnfaip6 Vps35l Ostf1 Ptx3 Gla Tnfsf11 Rps6ka1 Csf1 Ywhaz Nos2 Socs2 Prlr Pomc Ghr Cish Il17rc Il17ra Hnrnpa2b1 Vav3 Impdh1 Nme2 Vav2 Pcbp2 Xdh Hnrnpf Tlr1 Tlr6 Tlr2 Arih1 Actg1 Hsp90ab1 Rock1 Vim Oas2 Ltf Gbp2 Gbp3 Gbp9 Tomm70 Snrpa1 Furin Eif4g1 Cab39 Lamtor1 Lamtor2 H2-M5 Eif4e Ptpn22 H2-M3 Snap25 Vamp2 Stx1a Cebpd H2-Q1 Sar1b Bst2 Sec23a Il17f Il17a Pdia3 Sec24d Sec24c Ppie Sec24b Sec24a Clec5a Ddx3x Mmp9 Eif4g2 Eif4g3 Il18 Birc3 Edar Birc2 Eif4e3 Peli1 Bpifb1 Bpifb6 Bpifa1 Bpifa2 Traf2 Tnfsf4 Tnfsf8 Sdcbp Rnase6 Prkn Cd27 Cd70 Tnfsf15 Tnfsf14 Tnfsf12 Tnfsf18 Irf2 Tnfrsf11b Tnfrsf11a Fadd Tnfrsf17 Ube2l3 Tnfrsf25 Eppin Sla Elane Erap1 Itln1 Itch Ripk3 Tnfrsf13c Tnfrsf13b Tnfrsf12a Chga Siglec15 Casp8 Leap2 Casp4 Lpo Casp1 Ripk1 Edaradd Stub1 Dapp1 Gsdme Lta Ltb Gsdmd Ltbr Il1a Sla2 Il1b Tnfrsf4 Tnfrsf8 Tnfsf13b Pglyrp2 Pglyrp3 Pglyrp4 Tnfrsf9 Eda2r Reg3b Reg3g Eda Sigirr Il18bp Ptpn7 Ptpn9 Ptpn2 Ptpn5 Ptpn18 Il18r1 Hspa9 Ptpn23 Ptpn20 Ptpn13 Ptpn14 S100a1 Irak3 Cd36 Tirap Ube2b Camk2g Camk2d Ahcyl1 Camk2b Camk2a Nos1 Prdx6 Orai1 Orai2 Prkaca Stim1 Ccl12 Itpr3 Itpr2 Itpr1 Mapk9 Mapk7 Atox1 Mapk8 Txn Nectin2 Il6 Ifnb1 Rps6ka3 Il6st Rps6ka2 Map2k7 Map2k6 Map2k4 Map2k3 Mapk10 Plcg1 Pkm Ifi35 Bcl2 Ifi30 Gbp5 Gbp7 Bcl2l1 Pde12 Ifi27 Trim17 Trim14 Trim10 Eef2 Icam1 Atf6 Ifit2 Snca Adam10 Oas1g Egr1 Adam17 Fancl Fancm Fanca Fancb Rnasel Fance Fancf Fancg Pggt1b Hspa1l Rsad2 Trim6 Trim8 Trim3 Trim2 Ifit1bl2 Ifitm2 Trim12c Ifitm3 Faap24 Alox5 Ptgs2 Faap20 Ip6k2 Ilf2 Mid1 C3 C4a Flnb Oasl1 C5 Trim68 Cfb Isg20 C2 Faap100 Chit1 Vcam1 Mgam Hspa2 Trim46 Trim45 Adar Trim62 Ciita Oas3 Irf8 Samhd1 Irf6 Irf9 Trim26 Ifit3b Trim38 Trim35 Trim31 Ifi44l Eif2s3x Ist1 Eif2s2 Eif2s1 Tbc1d10c Pla2g6 Golga7 Prkcsh Fpr1 Il10 Myh9 Tifa Alpk1 Txnip Retn Ccl11 Lgals3 Gata3 Ccl22 Ccl20 Psap Cdk13 Ccl5 Ccl4 Ccl3 Junb Gpi Oprd1 Ppbp Ccr1 Ccr6 Wwp1 Ccr2 Socs3 Csf2 Cxcr1 Cxcr2 Csf1r Cxcl10 Itga4 Abl1 Bcl6 Il2ra Itgal Cxcl1 Cxcl3 Ptpn4 Ptpn1 Rnf34 Mrc2 Pml Sec61a2 Sec61a1 Tap2 Tap1 Cd207 Stx4 Tapbp Sec61b Capzb Apaf1 Capza1 Capza2 Rnf111 Timp1 Timp2 Fancc Fkbp5 Vegfa Lifr Ube2d3 Nedd4l Fbxo32 Irak1 Ybx1 Ifng Trim63 F12 Klkb1 Twist1 Sfn Tnfrsf18 Rorc Fcer1g Il12b Il10rb Il12a Il10ra Pin1 Tnf Tnfrsf1b Tnfrsf1a Lif Fcer2a Il1r2 Il1rn Csf3 Slc2a3 Stxbp2 Smarca4 A1bg Hrg Pten Orm3 Nlrc4 Ahsg Serpina3n Cd63 Col1a2 Rapgef4 Rapgef3 Cfl1 F13a1 Qsox1 Ctsk Ctsl Pecam1 Foxo1 Aamp Smurf2 Smurf1 Npm1 Kctd6 Oprm1 Il2 Smad3 Dbnl Smad7 Dctn1 Cat Kras Casp2 Iqgap1 Jak2 Fgb Fga Rap1b Fgg Raf1 Vcl Lta4h Defb47 Defb14 Defb36 Defb25 Defb15 Defb18 Defb29 Defb19 Defb23 Defb12 Atp6v0b Atp6v0a2 Atp6v0a4 Atp6v1g3 Hmox2 Limk1 Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Ftl1 Fth1 Cand1 Atp6v1e2 Atp6v1e1 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Cyld Atp6v1d Tnfaip3 Lcn2 Atp6v1h Tbk1 Zbp1 Irf3 Nlrp4e Dtx4 Plpp4 Plpp5 Pld3 Bola2 Stat4 Il23r Serpinb2 Aip Mif Hnrnpdl Lcp1 Ebi3 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription Snapc5 Snapc3 Snapc4 Snapc1 Snapc2 Znf143 Brf2 Polr3gl Gtf3a Crcp Polr3a Polr3d Nfix Brf1 Ssb Polr3e Nfia Polr1c Nfic Polr3b Polr3c Polr3h Polr3f Pou2f1 Polr1d Polr3g Polr3k Gtf3c2 Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 Gtf3c5 Bdp1 Tbp Polr2h Polr2e Polr2f Polr2k RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 96%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Csf2 Prkcb Crebbp Cbfb Lgals3 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system Pdcd4 Pitpna Il12rb1 Il12rb2 Il27 Ppia Il27ra Crlf1 Cnn2 Mmp9 Jak3 Il3ra Il2rb Tyk2 Csf2rb2 Csf2ra Il5 Blnk Eif4g2 Il5ra App Eif4g3 Jun Il18 Plcg2 Birc3 Edar Birc2 Eif4e3 Peli1 Ifnar1 Sod2 Traf2 Ifngr2 Tnfsf4 Ifngr1 Bcl2l11 Tnfsf8 S1pr1 Fasl Fnta Cd27 Fntb Cd70 Stat2 Tnfsf15 Il1r1 Tnfsf14 Foxo3 Tnfsf12 Irf2 Tnfsf18 Lmnb1 Tnfrsf11b Tnfrsf11a Tnfrsf17 Tnfrsf25 Sla Ctsg Tnfrsf13c Tnfrsf13b Rbx1 Tnfrsf12a Casp8 Casp1 Edaradd Lta Fcgr1 Ltb Gsdmd Ltbr Sla2 Il1a Tnfrsf4 Il1b Tnfrsf8 Syk Tnfsf13b Tnfrsf9 Eda2r P4hb Eda Sigirr Il18bp Ptpn7 Ptpn9 Ptpn2 Ptpn5 Il4 Ptpn18 Il18r1 Il13 Il18rap Hspa9 Ptpn23 Ptpn20 Ptpn13 Ptpn14 Brwd1 Irak3 Tslp Cd36 Crlf2 Il7 Rag2 Rag1 Il2rg Inpp5d Inppl1 Camk2g Sdc1 Camk2d Camk2b Camk2a Mtap Prkaca Ccl12 Mapk9 Mapk7 Mapk8 Abce1 Il34 Ptprz1 Il16 Prtn3 Txlna Ifnlr1 Stx3 Cd44 Il6 Irf5 Ccnd1 Hspa5 Cdkn1a Cdkn1b Flt3 Alox15 Ifnb1 Rps6ka3 Il6st Rps6ka2 Itgax Nup37 Map2k7 Nup160 Itgam Map2k6 Ppp2cb Ppp2ca Itgb2 Map2k4 Nup43 Map2k3 Mapk10 Ranbp2 Plcg1 Irf4 Ifi35 Bcl2 Ifi30 Ripk2 Gbp5 Myd88 Gbp7 Nup107 Bcl2l1 Pde12 Ifi27 Trim17 Trim14 Trim10 Nkiras1 Nkiras2 Icam1 Atf6 Lrrc14 Ifit2 Snca Vrk3 Ikbip Oas1g Egr1 Ppp2r1b Peli2 Ppp2r1a Adam17 Fancl Peli3 Fancm Fanca Fancb Tnip2 Rnasel Saa3 Nod2 Fance Nod1 Fancf Birc5 Fancg S100b Pggt1b Dusp3 Dusp4 Hspa1l Rsad2 Irak4 Trim6 N4bp1 Dusp7 Trim8 Nup85 Dusp6 Trim3 Trim2 Irak2 Ifit1bl2 Ager Nlrx1 Ifitm2 Mef2a Trim12c Ifitm3 Usp14 Alox5 Faap24 Usp18 Ptgs2 Faap20 Ip6k2 Taldo1 Ilf2 Mid1 Flnb Ppp2r5d Mmp2 Oasl1 Trim68 Isg20 Faap100 Ppp2r5a Sec13 Vcam1 Hspa2 Trim46 Trim45 Adar Trim62 Ciita Oas3 Irf8 Samhd1 Irf6 Irf9 Cenps Trim26 Ifit3b Trim38 Trim35 Trim31 Ifi44l Nup133 Eif2s3x Traf3 Eif2s2 Eif2s1 Prl Flt3l Casp3 Socs5 Socs6 Zeb1 Gab3 H2-Eb1 Myc Maoa Akt3 Akt2 Akt1 Ppm1b Eif2ak3 Hif1a Lyn Yes1 Fpr1 Il9 Il9r H3c7 Il10 Mt2 Tifa Alpk1 Nfkb2 Ccr5 Jak1 Fos Vav1 Pik3r1 Pik3r2 Ccl11 Tnfrsf14 Gata3 Ccl22 Ccl20 Pak2 Grap2 Ccl5 Ccl4 Ccl3 Stat3 Cd40lg Junb Stat1 Map3k14 Map3k8 Sh2b3 Oprd1 Tec Ifih1 Cd86 Cd80 Trim25 Mavs Rigi Ccr1 Pik3cb Pik3cd Ca1 Pik3ca Ccr2 Socs3 Lck Csf2 Irf1 Ptpn6 Csf1r Cd4 Ptpn11 Fyn Cxcl10 Lbp Csk Relb Rps6ka5 Bcl6 Il2ra Cxcl1 Dus2 Cxcl3 Itgb1 Ptpn4 Ptpn1 Flna Pml Eloc Stx4 Capza1 Anxa1 Ptpn12 Stat5a Stat5b Pim1 Grb2 Timp1 Fancc Fkbp5 Actb Pou2f1 Vegfa Sphk1 Tcp1 Lifr Muc1 Ube2d3 Anxa2 Il1rapl1 Irak1 Trp53 Abl2 Ybx1 Ifng Nup93 Nup50 Nup35 Nup54 Pom121 Nck1 Nup205 Ncam1 Nup188 Msn Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Kpna1 Sos2 Aaas Nup214 Nup210 Nup155 Il17rb Nup153 Il17re Cntf Cntfr Il1f10 Clcf1 Ctf1 Fscn1 Ptafr Map3k3 Il36rn Ndn Mcl1 Mmp1a Twist1 Il4ra Il15ra Il1rl2 Il1rl1 Il21r Il22b Il36b Il36a Eif2ak2 Il20rb Il20ra Sfn Il31ra Tollip Il36g Kpnb1 Il11 Il15 Il19 Hsp90aa1 Il22ra2 Osmr Rhou Il33 Il21 Il20 Il25 Il24 Osm Il17c Il22ra1 Batf Tgfb1 Il13ra1 Il13ra2 Ptk2b Kpna4 Ifnl3 Kpna7 Kpna3 Isg15 Elk1 Dnajc3 Sqstm1 Mmp3 Hspa1a Arf1 Tnfrsf18 Canx Vamp7 Hspa8 Gsto1 Rorc Irs1 Irs2 Fgf2 Il12b Il10rb Il12a Il10ra Tnf Pin1 Tnfrsf1b Tnfrsf1a Lif Thoc5 Fcer2a Il1r2 Il1rn Gab2 Csf3 Eif4a2 Eif4a1 Stxbp2 Smarca4 Csf3r Tnfsf13 Il6ra Prkcd Eif4a3 Nedd4 Sox2 Ube2l6 Hsp90b1 Prkra Col1a2 Tarbp2 Cfl1 F13a1 Grb10 Stat6 Irf7 Psma4 Dhx9 Ikbkb Psma3 Psma6 Foxo1 Fn1 Psma5 Psma2 Lama5 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Socs1 Skp1 Psmb5 Psmb4 Ube2m Psmb7 Il7r Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela B2m Npm1 H2-Q10 Btrc Psma7 Ptprj Psmc6 Psmc5 Psmc2 Psme2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Nfkbib Psmd8 Becn1 Psmd3 Psmd2 Psmb8 Psmd1 Nfkbia Adrm1 Sem1 Cenpx Cul1 Traf6 Ube2n Chuk Oprm1 Uba7 Ube2v1 Il2 Tab3 Tab2 Tab1 Rora Smad3 Smad7 Ube2i Uba3 Pias1 Cul5 Tnfsf11 Rps6ka1 Csf1 Ywhaz Nos2 Socs2 Prlr Pomc Ghr Cish Il17rc Il17ra Kras Hnrnpa2b1 Rnf7 Jak2 Rap1b Trim21 Raf1 Hnrnpf Cdk1 Arih1 Actg1 Ube2d1 Ube2e1 Src Vim Oas2 Cbl Gbp2 Gbp3 Hgf Gbp9 Shc1 Mapk1 Snrpa1 Furin Mapk3 Crkl Mapkapk3 Mapkapk2 Mapk14 Eif4g1 Rala Nras Map2k1 Rapgef1 Sos1 Crk Hras Mapk11 Lcn2 H2-M5 H2-M3 Eif4e Tbk1 Irf3 Snap25 Atf2 Vamp2 Stx1a Cebpd Hmox1 H2-Q1 Bst2 Il17f Il17a Bola2 Hck Stat4 Il23r Ilf3 Serpinb2 Mef2c Aip Mif Hnrnpdl Lcp1 Ebi3 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%180336 SHC1 events in EGFR signaling Egf Tgfa Shc1 Ereg Areg Hbegf Btc Epgn Nras Sos1 Hras Egfr PHOSPHOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%1483257 Phospholipid metabolism Pi4kb Pnpla6 Enpp6 Inpp5k Mtm1 Pnpla7 Pik3c2b Bmx Pik3c2g Fig4 Vac14 Mtmr3 Mtmr1 Tnfaip8 Mtmr7 Mtmr6 Awat2 Pip5k1b Mtmr9 Pip5k1a Mgll Slc44a3 Lpin3 Slc44a4 Gpat2 Slc44a5 Lpin2 Lpin1 Slc44a1 Slc44a2 Dgat2 Dgat1 Mtmr4 Gpd2 Sacm1l Pi4k2b Mtmr2 Pi4ka Sbf1 Ptpn13 Ptpmt1 Pisd Pcyt2 Abhd4 Osbpl10 Lpgat1 Pla2g15 Pgp Mboat1 Cpne1 Inpp5d Osbpl5 Cpne3 Pla1a Mfsd2a Synj1 Phospho1 Osbpl8 Pgs1 Pcyt1b Pcyt1a Dgat2l6 Cpne6 Abhd3 Cpne7 Pemt Selenoi Chpt1 Pld4 Crls1 Pctp Cds2 Hadha Stard10 Hadhb Cept1 Gpcpd1 Chka Pnpla3 Chkb Etnppl Plaat1 Plaat5 Inppl1 Etnk1 Ache Rab14 Bche Chat Pitpnb Arf1 Pik3c3 Cds1 Pik3r4 Cdipt Pitpnm3 Pitpnm1 Pla2g4a Pten Mboat7 Pip4p1 Agk Alpi Pik3c2a Synj2 Rab4a Pla2g2e Pla2g2d Pla2g2f Pla2g4d Ptdss1 Gpd1l Ptdss2 Lpcat4 Pld2 Pla2g12a Pip5k1c Acp6 Pla2g5 Lclat1 Gnpat Gpat4 Pla2g1b Gpat3 Pla2r1 Liph Pla2g4f Pnpla2 Pla2g4c Miga2 Pla2g4e Agpat5 Lpcat3 Pla2g10 Lpcat2 Miga1 Plbd1 Lpcat1 Plb1 Gpd1 Tmem86b Ddhd1 Pnpla8 Agpat3 Plaat3 Agpat4 Pla2g3 Agpat1 Pla2g6 Agpat2 Mboat2 Csnk2a2 Tafazzin Pik3r5 Pik3r6 Pik3r1 Pik3r2 Pip4k2b Pip4k2a Rab5a Pik3cg Pik3cb Pik3cd Pik3ca Ocrl Csnk2b Inpp5e Arf3 Pikfyve Gde1 Pi4k2a Sbf2 Plekha8 Plekha6 Plekha5 Inpp4a Stard7 Inpp4b Plekha3 Plekha2 Plekha1 Pld3 Tpte Tnfaip8l2 Mtmr10 Tnfaip8l3 Gdpd5 Tnfaip8l1 Mtmr14 Gdpd3 Mtmr12 Gdpd1 Pld1 Rufy1 Gpam Inpp5f DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion F8 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 96%3781860 Diseases associated with N-glycosylation of proteins Neu1 Mgat2 Mogs B4galt1 Alg14 Alg11 Alg9 Alg8 Ctsa Alg6 Man1b1 Alg3 Alg2 Alg1 Mpdu1 Glb1 Rft1 Dpagt1 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Slc25a4 Slc28a1 Arl2bp Slc29a3 Slc29a2 Arl2 Slc28a3 Slc28a2 Slc29a4 Slc29a1 Slc25a5 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-HSA-375165.5 NCAM signaling for neurite out-growth Cacnb1 Col4a1 Cacnb2 Cacna1d Prnp Pspn Col4a2 Col9a2 Col9a3 Nrtn Col6a6 Col6a3 Col4a5 Col9a1 St8sia2 Ncan Spta1 Sptb Mapk1 Ptk2 Mapk3 Agrn Sptan1 Nras Sos1 Hras Fyn Ncam1 Cacna1c Rps6ka5 Sptbn1 Sptbn2 Cntn2 Sptbn4 Gdnf Gfra1 Ptpra Artn Gfra2 Cacna1g Gfra4 Cacna1h St8sia4 Col6a1 Cacna1s Cacna1i Col4a3 Cacnb3 Col6a2 Cacnb4 Col4a4 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME%R-HSA-5619046.4 Defective SLC26A4 causes Pendred syndrome (PDS) Slc26a4 RHOQ GTPASE CYCLE%REACTOME%R-HSA-9013406.5 RHOQ GTPase cycle Jup Pak1 Arhgap32 Gja1 Pak4 Prex1 Arhgap35 Dlc1 Pak2 Plekhg3 Mpp7 Srgap2 Arhgef9 Arhgef7 Gopc Trip10 Slc1a5 Arhgap33 Git1 Tfrc Arhgap17 Wasl Lamtor1 Cdc42ep2 Cdc42ep3 Arhgap26 Cdc42ep4 Syde1 Wwp2 Steap3 Git2 Arl13b Gfod1 Snap23 Rab7 Cftr Cdc42bpa Cdc42bpb Diaph3 Slc4a7 Cdc42ep1 Depdc1b Fnbp1 Vamp3 Cpne8 Scrib Iqgap3 Itsn1 Arhgap5 Cav1 Arhgap1 Arhgap21 Stom Vangl1 Ophn1 Iqgap1 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome Pycard Aim2 Casp1 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 96%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex Chmp2a Map1lc3b Becn1 Pik3r4 Uvrag Pik3c3 Chmp4c Chmp4b Chmp3 Chmp7 Chmp6 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 96%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Diablo Apaf1 Xiap Casp3 Casp7 Casp9 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins Cetn2 Brca1 Nup133 Cdkn2a Parp1 Smc1a Pcgf2 Xpc Ring1 Cbx8 Phc2 Phc1 Cbx4 Cbx2 Phc3 Smc6 Smc5 Nsmce4a Eid3 Bmi1 Nsmce1 Nsmce3 Nsmce2 Smc3 Nup37 Nup160 Rnf2 Nup43 Sumo3 Ranbp2 Rad21 Nup93 Pias4 Nup50 Nup35 Nup54 Pom121 Nup205 Ube2i Nup188 Tpr Hdac7 Nup107 Rae1 Pias1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Rnf168 Stag2 Nup210 Nup155 Stag1 Nup153 Rad52 Mdc1 Xrcc4 Nup85 Blm Wrn Herc2 Pml Sec13 Rpa1 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME DATABASE ID RELEASE 96%9827857 Specification of primordial germ cells Tet2 Prdm1 Pdpn Cxcr4 Sox17 Bmp4 Tfap2c Eomes Pou5f1 Nanos3 Cbfa2t2 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%74752 Signaling by Insulin receptor Insr Grb10 Ctsd Flt3l Atp6v0b Atp6v0a2 Atp6v0a4 Atp6v1g3 Pik3cb Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Ptprf Pik3ca Shc1 Mapk1 Mapk3 Flt3 Pdpk1 Atp6ap1 Atp6v1e2 Atp6v1e1 Klb Tcirg1 Fgf16 Frs2 Fgf15 Them4 Irs1 Atp6v1a Fgf18 Atp6v1b2 Irs2 Ide Atp6v0d2 Fgf2 Atp6v0d1 Pik3c3 Atp6v1b1 Fgf1 Nras Atp6v0e1 Fgf4 Gab1 Atp6v1g2 Fgf10 Atp6v1g1 Fgf3 Fgf6 Sos1 Fgf7 Atp6v1f Fgf9 Atp6v1d Hras Trib3 Fgf20 Gab2 Ptpn11 Fgf23 Atp6v1h Fgfr4 Fgf22 Akt2 Pde3b Tlr9 Pik3r4 Ptpn1 Ins2 Pik3r1 Pik3r2 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702614 ponatinib-resistant FLT3 mutants Flt3 METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids Acat2 Sp1 Cyp51a1 Ltc4s Elovl6 Dhcr7 Srebf2 Ggt1 Awat2 Alox12 Angptl4 Ldlrap1 B3gnt5 Nr1h3 Dpep1 Dpep2 Sult2a1 Prkacb Ggt5 Slc44a3 Slc44a4 Slc44a5 Slc44a1 Apoa2 Slc44a2 Apoa5 Abca1 Slc22a5 Alb Sacm1l Cubn Pi4k2b Far2 Mtmr2 Far1 Pi4ka Mcat Sbf1 Acad11 Acad10 Alox8 G0s2 Ptgr2 Slc25a20 Acot3 Hsd17b1 Acot9 Acot7 Ptgs1 Tnfrsf21 Ptpn13 Ankrd1 Hsd17b13 Ptpmt1 Fitm2 Pisd Pcyt2 Fitm1 Cd36 Abhd4 Hilpda Osbpl10 Awat1 Lpgat1 Fhl2 Them5 Pla2g15 Pgp Cpt1b Ptges Mboat1 Inpp5d Mid1ip1 Cpne1 Faah Osbpl5 Cpne3 Prxl2b Synj1 Pla1a Acot11 Acot12 Osbpl8 Pgs1 Acot13 Cbr1 Dgat2l6 B4galt5 Cpne6 Grhl1 Cpne7 Acaa2 B4galt6 Selenoi Acbd6 Pld4 Acbd7 Crls1 Cds2 Acsf2 Gpcpd1 Dbi Pnpla3 Cpt2 Etnppl Pon3 Plaat1 Pon1 Inppl1 Plaat5 Pon2 Etnk1 Abcc3 Slc25a17 Cyp11a1 Me1 Akr1b1 Rab14 Prkaca Pitpnb Hexa Hexb Mcee Glb1 Pcca Mmaa Pccb Mmut Glb1l3 Glb1l2 Arsb Ptgis Tbxas1 Cyp8b1 Stard3nl Nrf1 Stard4 Stard3 Star Tspo Alox5ap St6galnac6 Alox15 Cyp4f39 Cyp4f17 Abcc1 Cyp24a1 Cyp4a12b Cyp4f3 Cyp4f40 B3galt4 Cyp4b1 Ptgr1 Fut2 Fut1 Thrap3 Fam120b Olah Hsd17b8 Hsd17b3 Acly Elovl4 Hacd1 Morc2a Hsd17b12 Elovl1 Hacd2 Hacd3 Elovl7 Hacd4 Cbr4 Tecrl Hsd3b6 Tecr Cyp21a1 Acsbg1 Hsd3b1 Acsbg2 Acsl5 Cyp11b2 Ppt2 Acsl6 Acsl3 Slc27a3 Ppt1 Acsl4 Acsf3 Mboat7 Alox5 Ptgs2 Cpt1a Ppp1cc Agk Alpi Cyp2r1 Rab4a Pla2g2e Pla2g2d Pla2g2f Pla2g4d Ptdss1 Gpd1l Elovl3 Ptdss2 Lpcat4 Cidea Pld2 Pla2g12a Acp6 Pla2g5 Lclat1 Gnpat Gpat4 Pla2g1b Gpat3 Pla2r1 Liph Pla2g4f Pla2g4c Miga2 Agpat5 Pla2g4e Lpcat3 Pla2g10 Lpcat2 Miga1 Plbd1 Lpcat1 Plb1 Gpd1 Ddhd1 Tmem86b Pnpla8 Csnk1g2 Agpat3 Plaat3 Agpat4 Agpat1 Pla2g3 Agpat2 Pla2g6 Mboat2 Fdx1 Asah1 Fdxr Fdx2 Trib3 Prkaa2 St3gal2 Plin2 Osbpl1a Csnk2a2 Fads2 Slco1a4 Fads1 Med8 Pik3r5 Pik3r6 Med4 Pik3r1 Med6 Pik3r2 Pip4k2b Pip4k2a Psap Echs1 Acsm3 Acads Hadh Ppard Lhb Gps2 Rab5a Pik3cg Pik3cb Pik3cd Prkag2 Pik3ca Csnk2b Them4 Slc10a2 Slc10a1 Stard5 Inpp5e Slc27a5 Slc51a Slc51b Prkab2 Cdk8 Sin3a Arf3 Lbr Pikfyve Gde1 Pi4k2a Gpx2 Sbf2 Plekha8 Plekha6 Plekha5 Inpp4a Inpp4b Stard7 Plekha3 Plekha2 Plekha1 Tpte Tnfaip8l2 Mtmr10 Tnfaip8l3 Gdpd5 Tnfaip8l1 Mtmr14 Gdpd3 Mtmr12 Gdpd1 Pld1 Rufy1 Inpp5f Vapb Pi4kb Pnpla6 Enpp6 Inpp5k Mtm1 Pnpla7 Pik3c2b Bmx Pik3c2g Fig4 Havcr2 Vac14 Mtmr3 Acadvl Mtmr1 Tnfaip8 Mtmr7 Mtmr6 Gba1 Pip5k1b Cyp2u1 Mtmr9 Gk Esrra Plin3 Pip5k1a Cyp1b1 Pnpla5 Cyp4a32 Plin1 Cyp4f15 Abhd5 Mgll Ppp1ca Fabp1 Ppp1cb Fabp2 Fabp3 Fabp4 Fabp5 Fabp6 Fabp7 Mogat1 Lpin3 Gpat2 Sphk1 Lpin2 Ncoa3 Lpin1 Mogat2 Gk2 Fabp12 Dgat2 Dgat1 Lipe Mtmr4 Gpd2 Fabp9 Cyp39a1 Cyp11b1 Cyp27b1 Cyp46a1 Slc27a1 Ugt1a9 Ptgds Aloxe3 Gpx4 Alox12b Mfsd2a Phospho1 Gstm4 Pcyt1b Pcyt1a Abhd3 Pemt Chpt1 Hpgds Pctp Hadha Srd5a3 Stard10 Hadhb Cept1 Chka Acadl St6galnac5 Chkb Cyb5b Smpd2 Smpd3 Agt Ache Ctsa St8sia5 Kpnb1 Med23 Neu2 Med24 Neu3 Med25 Med20 Bche Neu1 Med26 Med27 Med12 Med13 Chat St3gal5 Med14 Med10 Med15 Med16 Med17 Ncor2 Arf1 Dhrs7b Srebf1 Gc Oxct2a Ran Hmgcl Bdh2 M6pr Bdh1 Oxct1 Hmgcll1 Hmgcs2 Acat1 Aacs Srd5a1 Srd5a2 Cyp17a1 Fasn Med30 Med31 Rgl1 Pik3c3 Sumf1 Sumf2 Arsa Smpd1 Acbd5 Cds1 Pik3r4 Cdipt Pitpnm3 Pitpnm1 Acoxl Arnt Arsk Arsj Arsi Pla2g4a Arsg Pten Mecr Eci1 Acadm Decr1 Lgmn Glipr1 Ptges2 Ccnc Pip4p1 Ormdl3 Pik3c2a Synj2 Gm2a Pex11a Lrp2 Elovl5 Cidec Pip5k1c Ppargc1b Acsl1 Pnpla2 Thrsp Nr1h4 Akr1c21 Hsd3b7 Cyp27a1 Akr1d1 Rxrb Aldh3b1 Cyp7a1 Cyp7b1 Degs1 Akr1c6 Phyh Amacr Vdr Hacl1 Nr1h2 Rora Ppara Crot Scp2 Gla Pparg Crat Alas1 Pias4 Acox2 Nudt19 Rxra Cyp19a1 Acot2 Ube2i Acox3 Txnrd1 Baat Agps Hao2 Nudt7 Pecr Ephx2 Pomc Med9 Cdk19 Tafazzin Med13l Cav1 Abcb4 Vapa Acbd4 Serpina6 Hsd11b1 Hsd11b2 Cga Mfsd2b Sgpl1 Prkd3 Sptssa Sptssb Slco1b2 Prkd1 Prkd2 Cers6 Plpp2 Cers5 A4galt Tiam2 Gba2 Plpp3 Abcb11 Cers4 Cers3 Plpp1 Cers2 Hpgd Asah2 Lta4h Sgms1 Sgms2 Sptlc1 Ahr Cerk Sptlc2 Cyp2d22 Ndufab1 Sptlc3 Cyp3a16 Fa2h B3galnt1 Cyp2c65 Sphk2 Kdsr Ugcg Cyp2j6 Lass1 Smpd4 Cyp2e1 Enpp7 Cyp1a1 Galc Ahrr B4galnt1 Ormdl1 Cyp2c50 Ugt8 Cyp1a2 Acot8 Acer1 Hsd17b4 Acer2 Ehhadh Gal3st1 Acaa1a Acer3 Ormdl2 Slc27a2 Degs2 Abcd1 Samd8 Decr2 Acot4 Ppm1l Osbp Sgpp2 Sgpp1 Ch25h Hsd17b11 Hsd17b14 Osbpl3 Osbpl2 Osbpl7 Osbpl6 Osbpl9 Med22 Hsd17b2 Abcg2 Med21 Akr1b8 Med28 Med29 Med11 Med19 Ocrl Mapkapk2 Med18 Ncor1 Helz2 Carm1 Ep300 Tbl1x Clock Akr1c18 Fdft1 Insig1 Bmal1 Insig2 Hdac3 Ggps1 Sc5d Scd1 Sar1b Ncoa2 Ncoa1 Lss Tm7sf2 Sec23a Tbl1xr1 Pmvk Smarcd3 Mtf1 Scap Ncoa6 Mvd Acacb Acaca Npas2 Fdps Med1 Idi1 Pld3 Mvk Nfyb Nr1d1 Nfya Nfyc Ppargc1a Sec24d Plpp6 Sec24c Mbtps1 Hsd17b7 Crebbp Nsdhl Mbtps2 Dhcr24 Apoa1 Sec24b Sqle Ebp Chd9 Arv1 Sec24a Gpam Msmo1 SIGNALING BY RAS GTPASE MUTANTS%REACTOME%R-HSA-9753512.2 Signaling by RAS GTPase mutants Kras Nras Hras SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions Slc16a8 Slc16a7 Slc16a1 Slco1b2 Slco4a1 Slc22a12 Slc5a8 Slc25a10 Slc25a1 Slc5a12 Slc17a5 Slc44a3 Slco1c1 Slc5a7 Slc44a4 Slc13a5 Slc44a5 Slc13a3 Slc10a6 Avp Slc44a1 Slc44a2 Slc13a2 Slco1a4 Slc25a11 Slc22a8 Slc22a6 Slco4c1 Bsg Slco2b1 Slco2a1 Slc16a2 Slc16a3 Emb DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 96%5579028 Defective CYP17A1 causes AH5 Cyp17a1 MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 96%1222449 Mtb iron assimilation by chelation Ltf DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o Dpm1 Dpm2 Dpm3 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes Kmt2d Kmt2b Setd1b Setd1a Pagr1a Rbbp5 Phf20 Cxxc1 Kdm6a Tasp1 Akap8l Paxip1 Hcfc1 Kat8 Yeats2 Wdr82 Psip1 Kat14 Hcfc2 Dr1 Phf20l1 Tada3 Tada2a Bod1 Zzz3 Mbip Kansl3 Ncoa6 Kansl1 Kansl2 Kat2b Ash2l Bod1l Kat2a Kmt2c Sgf29 Ogt Dpy30 Wdr5 Men1 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%74259 Purine catabolism Nt5c2 Nt5e Gda Xdh Nudt16 Adprm Nudt5 Nt5c Nt5c1a Pnp Dnph1 Itpa Nudt15 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME%R-HSA-210746.3 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells Neurog3 Nkx2-2 Insm1 Neurod1 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 96%168176 Toll Like Receptor 5 (TLR5) Cascade Mapk9 Mapk7 Mapk8 App Ikbkb Jun Peli1 Elk1 Ikbkg Map3k7 Traf2 Map3k8 Nfkb1 Skp1 Fbxw11 Rela Btrc Casp8 Ubc Mapk1 Nfkbib Mapk3 Rps6ka3 Irak1 Nfkbia Mapkapk3 Rps6ka2 Traf6 Mapkapk2 Cul1 Ube2n Map2k7 Mapk14 Chuk Map2k6 Ppp2cb Ppp2ca Ube2v1 Trp53 Map2k4 Tab3 Map2k3 Tab2 Tab1 Mapk10 Map2k1 Mapk11 Ripk2 Myd88 Rps6ka5 Nkiras1 Atf2 Nkiras2 Rps6ka1 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Peli2 Ppp2r1a Peli3 Tlr5 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Tifa Dusp6 Alpk1 Irak2 Ager Nlrx1 Nfkb2 Mef2a Usp14 Usp18 Fos Ppp2r5d Mef2c DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME%R-HSA-4549380.4 Defective ALG1 causes CDG-1k Alg1 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME%R-HSA-9854311.2 Maturation of TCA enzymes and regulation of TCA cycle Cs Fxn Acat1 Sdhd Isca2 Sdhc Sdhb Sdha Sdhaf1 Sdhaf2 Sdhaf3 Sdhaf4 Lyrm4 Aco2 Idh2 Sirt3 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 96%9918487 Dengue Virus Genome Translation and Replication Sun2 Xrn1 Magt1 Kpna4 Dnaja2 Kpna7 Eif4g2 Eif4g3 Kpna3 Eif4e3 Dnajc3 Tmem258 Calr Hspa1a Sec11c Sec11a Stt3a Canx Stt3b Vcp Hdlbp Ostc Vim Hspa8 Rrbp1 Ubc Tusc3 Hspa5 Map1lc3b Dad1 Fasn Eif4g1 P4hb Ddost Atl2 Dnajc10 Ybx1 Pabpc1 Prkg2 Ube2i Acot2 Eif4e Eif4a2 Eif4a1 Kpna1 Rpn2 Rpn1 Eif4a3 Xpo1 Ufd1 Hyou1 Nploc4 Dpm1 Dpm2 Scap Dpm3 Nmt1 Spcs3 Btf3 Spcs1 Spcs2 Dnajb11 Pdia3 Kpnb1 Ipo7 Apoa1 Bag2 P4ha1 Rtn3 P4ha2 P4ha3 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs Brca1 H2ac20 Stambpl1 Psmd14 Abraxas1 Abraxas2 Brcc3 Ep300 Stambp Babam1 Babam2 H2ac12 Nlrp3 Uimc1 H2ac11 Stam H2ac15 H2ac21 H2ac25 Hist1h2af H2ac1 Ubc Kat2b Mysm1 Bard1 Hist2h2aa1 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development Actl6a Smarce1 Trpm1 Ywhae Actb Myo5a Cdc25b Usf1 Gmpr Ednrb Cdh2 Lars1 Pxn Tfeb Birc7 Mitf Asah1 Eef1e1 Pxdn Mark3 Edil3 Ywhah Zeb1 Kars1 Tert Hdac1 Gxylt2 Tfec Tbx2 Ube2i Zic1 Bcl2a1d Sox9 Akt3 Edn1 Akt2 Edn3 Tfe3 Pax3 Lig1 Tnfsf11 Foxd3 Mc1r Rps6ka1 Mars1 Wnt3a Kit Mc5r Tcf7l1 Csf1 Tcf7l2 Ywhaz Mov10 Dars1 Hint1 Qars1 Rars1 Ago4 Mc4r Ago3 Pomc Id1 Ago2 Alx3 Ago1 Pou3f2 Sox10 Aimp2 Aimp1 Eprs1 Snai2 Iars1 Tbx3 Mc3r Diaph1 Brca1 Plk1 Cdkn2a Stt3b Atp6v0b Ctnnb1 Tcf7 Arid1a Arid1b Cdh1 Ccnd1 Cdk2 Met Atp6v1c1 Mcm5 Serpine1 Dct Mapk1 Tyrp1 Cdkn1a Tyr Mcm2 Mapk3 Ywhab Ywhag Gpr143 Atp6v1e1 Mapk14 Ss18 Mlph Atp6v1a Dpf1 Atp6v1b2 Gsk3b Dpf2 Rab27a Atp6v0d1 Dpf3 Mlana Atp6v0e1 Ss18l1 Lef1 Pmel Atp6v1g1 Bcl7a Bcl7b Bcl7c Irf4 Myrip Tfap2a Sytl2 Smarcb1 Atp6v1h Bcl2 Tnrc6c Tnrc6a Smarca2 Tnrc6b Smarca4 Ep300 Itga2 Smarcd1 Smarcd2 Sin3a Smarcc2 Smarcc1 Sox2 Xpo1 Smarcd3 Dicer1 Ppargc1a Crebbp Sirt1 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis Coasy Pank3 Pank2 Ppcs Pank1 Dcakd Ppcdc DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex Ppp2r5e Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Zranb1 Psmd12 Psmd11 Psmd14 Tle3 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Ctnnb1 Btrc Tcf7 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Ctbp1 Psmd3 Ctbp2 Psmd2 Psmd1 Adrm1 Sem1 Amer1 Cul1 Tle4 Ppp2cb Ppp2ca Tle2 Tle1 Gsk3b Lef1 Csnk1a1 Frat2 Frat1 Hdac1 Tcf7l1 Tcf7l2 Ppp2r1b Apc Ppp2r1a Tle5 Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Axin1 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 96%8934903 Receptor Mediated Mitophagy Map1lc3b Map1lc3a Fundc1 Atg5 Atg12 Ulk1 Csnk2a2 Csnk2b G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events Gnat3 Rgs20 Rgsl1 Gng10 Prkca Prkcg Gng3 Gng2 Gng4 Gng7 Prkch Gng8 Prkce Rgs17 Rgs19 Gngt1 Rgs16 Gngt2 Prkcb Prkcd Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Gnaz Adcy9 Gnb2 Gnb1 Gnb4 Rgs4 Gnai2 Gnb3 Gnai1 Gnb5 Gng11 Gnai3 Adra2a Gng12 Adra2c Gng13 Adra2b Prkcq DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 96%4793950 Defective MAN1B1 causes MRT15 Man1b1 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139910 Activation of BMF and translocation to mitochondria Bmf Dynll2 Mapk8 SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo Tjp1 Mob1a Casp3 Lats1 Mob1b Lats2 Amotl2 Amotl1 Tjp2 Stk4 Sav1 Stk3 Wwtr1 Ywhae Ywhab Dvl2 Yap1 Wwc1 Nphp4 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity Stam2 Sh3gl3 Sh3kbp1 Stam Eps15 Ptpn2 Ptprj Cbl Hgs Usp8 Sh3gl1 Sh3gl2 Hgf Ubc Met Ptpn1 Lrig1 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655332 Signaling by FGFR3 in disease Fgf16 Frs2 Fgf18 Fgf2 Fgf1 Nras Gab1 Fgf4 Plcg1 Sos1 Fgfr3 Fgf9 Hras Fgf20 Pik3ca Fgf23 Pik3r1 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 96%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) Ube2i Sumo3 Uba2 Sae1 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) Suclg1 Suclg2 Isca2 Sucla2 Trap1 Sdhaf1 Idh3a Sdhaf2 Sdhaf3 Sdhaf4 Lyrm4 Aco2 Idh3b Nnt Cs Fh Fxn Dld Mdh2 Acat1 Sdhd Sdhc Sdhb Idh3g Ogdh Sdha Dlst Idh2 Sirt3 SIGNALING BY LTK%REACTOME%R-HSA-9842663.1 Signaling by LTK Pik3ca Grb2 Ltk Irs1 Tnk2 Alkal1 Pik3r1 Pik3cb Sos1 Pik3r2 ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins Prss2 Art1 Cd4 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation Ikbkg Tasl Slc15a4 Irf5 Ikbkb Chuk SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin Epo Jak2 Irs2 Nras Gab1 Plcg1 Rapgef1 Pik3cg Pik3cb Sos1 Stat5a Pik3cd Stat5b Hras Plcg2 Pik3ca Shc1 Epor Vav1 Crkl Pik3r5 Pik3r1 Lyn CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 96%9909396 Circadian clock Ppp1cc Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Ppp1ca Cdk5 Psmd14 Psmd13 Ppp1cb Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Avp Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Fbxl3 Rora Tfeb Ppara Rxra Nampt Csnk2a2 Csnk1d Sik1 Rbm4 Dbp Cipc Ube2d1 Cry1 Cry2 Per1 Per3 Srebf1 Serpine1 Csnk2b Rorc Rorb Csnk1e F7 Ncor1 Atf2 Helz2 Carm1 Nrip1 Ep300 Tbl1x Mef2d Clock Bmal1 Crtc3 Hdac3 Crtc2 Rai1 Ncoa2 Ncoa1 Tbl1xr1 Smarcd3 Crtc1 Ncoa6 Npas2 Med1 Cpt1a Nr1d1 Ppargc1a Crebbp Bmal2 Mef2c Bhlhe40 Chd9 Bhlhe41 Noct Sirt1 Klf15 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation Rnf135 Trim25 Saa3 Mavs Rela Rigi S100b App Ikbkb Ager Nfkb2 Nfkbib Ikbkg Traf2 Nkiras1 Nkiras2 Nfkbia Nfkb1 Traf6 Map3k1 Chuk Ifih1 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 96%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Gata4 Pcsk1 Ffar1 Pax6 Gpr119 Spcs3 Spcs1 Spcs2 Isl1 Gip Sec11c Sec11a Dpp4 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME DATABASE ID RELEASE 96%5619055 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) Slc24a4 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) Pygl Pgm1 Pygm Phkg1 Phkb Phkg2 Akr1e2 Phka1 Phka2 Gyg1 Gaa Pygb Agl METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins Ace Ctsz Ctsg Anpep Cpb1 Agt Ace2 Ces1d Cma1 Cpa3 Mme Ctsd Enpep Cpb2 Atp6ap2 Gzmf REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation Tnrc6c Ago4 Ago3 Ago2 Ago1 Tnrc6a Tnrc6b Npas4 Mov10 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 96%442755 Activation of NMDA receptors and postsynaptic events Prkaca Dlg1 Camkk1 Dlg3 Camkk2 Dlg4 Gria4 Gria3 Prkx Gria1 Cask Lin7a Lin7b Lin7c Grin3b Rasgrf1 Rasgrf2 Prkacb Src Kif17 Nrg1 Adcy1 Rps6ka6 Prkag3 Adcy8 Prkag1 Prkag2 Mapk1 Apba1 Mapk3 Nrgn Rps6ka3 Pdpk1 Rps6ka2 Prkar1b Git1 Prkar2b Gria2 Nras Hras Prkaa1 Grin2b Prkaa2 Prkar1a Rps6ka1 Grin2a Prkab2 Camk4 Prkab1 Camk1 Dlg2 Actn2 Prkar2a Ppm1f Nefl Ppm1e Grin1 Grin2d Grin2c Camk2g Camk2d Camk2b Rac1 Camk2a RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development Hey2 Hey1 Smad1 Smad4 Ar Smad6 Hdac4 Hdac6 Abl1 Hes1 Gli3 Ucma Gli2 Rbm14 Yes1 Satb2 Src Hdac3 Rb1 Ihh Cbfb Znf521 Wwtr1 Maf Mapk1 Mapk3 Sp7 Col1a1 Yap1 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-HSA-8964539.5 Glutamate and glutamine metabolism Rimkla Gls2 Glul Rimklb Gls Glud1 Got2 Pycr3 Pycr2 Oat Pycr1 Kyat1 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 96%70171 Glycolysis Prkaca Pfkm Pfkp Adpgk Aldob Aldoc Aldoa Nup133 EG433182 Gpi Prkacb Gnpda1 Gck Gnpda2 Gapdhs Nup37 Nup160 Gckr Ppp2cb Ppp2ca Pgk1 Nup43 Ranbp2 Eno3 Eno2 Nup93 Nup50 Pgk2 Nup35 Eno4 Nup54 Pom121 Nup205 Hk2 Nup188 Hk1 Tpr Hk3 Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Pfkfb4 Nup214 Pfkfb3 Pfkfb1 Nup210 Nup155 Nup153 Ppp2r1b Ppp2r1a Hkdc1 Pgm2l1 Nup85 Bpgm Ppp2r5d Pgam2 Pfkl Pgam1 Tpi1 Sec13 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation Ppp1cc Xpo1 Csnk2a2 Hspa8 Spcs3 Spcs1 Spcs2 Furin Ppp1ca Kpnb1 Ppp1cb Hsp90aa1 Sec11c Csnk2b Hsp90ab1 Sec11a REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME%R-HSA-9854907.3 Regulation of MITF-M dependent genes involved in metabolism Ppargc1a Sirt1 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 96%418890 Role of second messengers in netrin-1 signaling Trpc3 Pitpna Dcc Plcg1 Trpc6 Trpc5 Ntn1 Trpc7 Trpc1 Trpc4 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA Dcp1a Tnpo1 Xrn1 Exosc9 Exosc8 Exosc5 Dis3 Exosc4 Exosc7 Exosc6 Ywhab Zfp36 Exosc1 Exosc3 Exosc2 Dcp2 Mapkapk2 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 96%983231 Factors involved in megakaryocyte development and platelet production Capzb Capza1 Capza2 Rcor1 Hmg20b Cdk5 Kdm1a Cenpe Prkacb Irf2 Mfn1 Mfn2 Dock7 Kif3a Cbx5 Kif3b Kif3c Akap1 Kif4 Prkar1b Trp53 Prkar2b Hdac1 Zfpm2 Prkar1a Kif26a Kif11 Kif15 Prkar2a Kif22 Kif23 Kif20a Klc1 Itpk1 Klc4 H3c7 Klc3 Klc2 Dock8 Rad51c Rad51b Mafg Rac1 Myb Akap10 Ak3 Kifap3 Gata5 Hbb-y Maff Ehd1 Ehd2 Gata3 Ehd3 Prkaca Gata4 Mical1 Jak2 Hbb-bh1 Gata1 Jmjd1c Gata2 Kif18b Cables2 Vps45 Carmil1 Kif26b Sh2b1 Kifc2 Kif12 Kif21a Kif1c Nfe2 Kif21b Kif13b Kif1a Kif1b Kif6 Kif9 Kif27 Kif16b Kif20b Kif19a Sh2b2 Sh2b3 Rbsn Rab5a Cdk2 Cables1 Dock11 Ifnb1 Wee1 Kif5b Irf1 Kif2a Kif2b Kif2c Dock3 Hdac2 Abl1 Dock10 Racgap1 Dock6 Gata6 Kif18a Sin3a Dock5 Mafk Hbbt1 Dock4 Zfpm1 Dock1 Dock2 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis Ssbp1 Mterf1b Ppara Alas1 Rxra Atp5f1b Sirt4 Esrra Tfb2m Sod2 Tfam Ncor1 Atf2 Helz2 Carm1 Acss2 Camk4 Hcfc1 Tbl1x Mef2d Glud1 Gabpa Crtc3 Hdac3 Pprc1 Crtc2 Sirt5 Nrf1 Ncoa2 Ncoa1 Ppargc1b Tbl1xr1 Tfb1m Smarcd3 Crtc1 Ncoa6 Med1 Polg2 Nr1d1 Ppargc1a Twnk Crebbp Mef2c Polrmt Chd9 Idh2 Sirt3 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs Hpgd Alox5 Lta4h Ptgs2 Alox15 DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 96%5579019 Defective FMO3 causes TMAU Fmo3 KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization Capn1 Capns1 Krt1 Klk13 Dsp Pkp1 Dsg2 St14 Dsg3 Dsg1a Cdsn Loricrin Klk5 Kazn Sprr1b Klk8 Ppl Tgm1 Lce1m Tgm5 Casp14 Lce3b Pkp4 Tchh Prss8 Evpl Cela2a Perp Spink5 Csta2 Sprr2k Pkp2 Klk12 Pkp3 Dsg4 Lipk Dsc1 Klk14 Rptn Dsc2 Lipn Dsc3 Jup Krtap3-1 Krt4 Krt2 Krtap3-2 Krt8 Krt7 Krt5 Krtap16-3 Krtap12-1 Krt6a Krt9 Krt71 Krt78 Krt79 Krt76 Krt77 Krt75 Krt72 Krt73 Krtap24-1 Krtap4-25 Krtap4-23 Krtap4-7 Krt40 Krt33b Krt33a Krtap4-2 Krtap17-1 Krtap13-1 Krtap20-1 Krtap4-16 Krt27 Krt25 Krt26 Krt23 Krt24 Krt20 Krtap9-5 Krtap1-3 Krt39 Krtap13-20 Krtap1-4 Krt34 Krt35 Krt32 Krt31 Krtap26-1 Furin Krt82 Pcsk6 Krt80 Krt87 Krt85 Krt86 Krt84 Krt18 Krt16 Krt17 Krtap2-4 Krt14 Krt15 Krtap19-4 Krtap15-1 Krt12 Krt13 Krt10 CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER Stx5 Mia3 Gria1 Tgfa Ctsc Areg Lman2 Lman1 Sec22b Preb Ctsz Sar1b F5 F8 Sec23a Gosr2 Lman1l Cd59b Mcfd2 Sec24d Lman2l Sec24c Serpina1d Cnih1 Sec24b Col7a1 Cnih3 Cnih2 Sec24a Folr1 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation ATP6 mt-Nd4 mt-Nd5 mt-Nd6 Gfm2 mt-Nd1 mt-Nd2 mt-Nd3 Mrrf Mtrf1 Mtrf1l mt-Nd4l mt-Co1 Mrpl10 Mrpl54 Dap3 Mrpl11 Mrpl55 Tsfm Mrpl12 Gfm1 Mrpl13 Mrpl57 Mrpl58 Mrpl14 Mrps30 Mrpl16 Mrps31 Mrpl17 Mrps33 Mrpl18 Mrpl19 Aurkaip1 Mrps34 Mrps35 Tufm Gadd45gip1 Mrpl20 Mrpl3 Mrpl43 Mrpl4 Mrpl44 mt-Co2 mt-Co3 Mrpl1 Mrpl46 Mrpl2 Mrpl47 Mrpl48 Mrpl49 Ndufab1 Mrps21 Mrps22 Mrps23 Mrps24 Mrpl9 Mrps25 Mrps26 Mrps27 Mrps28 Mrps18c Mrps18b Mrps18a Mrpl50 Mrpl51 mt-Cytb Mrpl52 Mrpl53 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrps9 Mrpl36 Mrpl37 Mrpl38 Mrpl39 Mrps10 Mrps11 Mrps12 Mrps14 Chchd1 Mrps15 Mrps16 Mrps17 Ptcd3 Mrps2 Mrps6 Mrps7 Mrpl40 Mrpl41 Mrps5 Mrpl21 Mrpl22 Mrpl24 Mrpl28 Eral1 Mrpl30 Mief1 Mtres1 Mtfmt Mtif3 Mtif2 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 96%202670 ERKs are inactivated Ppp2cb Ppp2ca Dusp3 Dusp4 Mapk7 Dusp7 Dusp6 Mapk1 Mapk3 Ppp2r5d Vrk3 Ppp2r1b Ppp2r1a INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020933 Interleukin-23 signaling Jak2 Il12rb1 Stat3 Il12b Stat4 Il23r Tyk2 P4hb DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere Atrx Daxx RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 96%1810476 RIP-mediated NFkB activation via ZBP1 Rela Ripk3 Dhx9 Ikbkb Ripk1 Nfkb2 Myd88 Nfkbib Zbp1 Ikbkg Ticam1 Tlr3 Nkiras1 Nkiras2 Nfkbia Nfkb1 Chuk HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 96%3371497 HSP90 chaperone cycle for SHRs Nr3c2 Nr3c1 Capzb Capza1 Capza2 Actr1a Dnaja2 Dync1li2 Ar Dctn2 Dctn3 Dync1li1 Dnajb1 Pgr Actr10 Dctn5 Dynll1 Dctn6 Dctn1 Dynll2 Dctn4 Capza3 Fkbp5 Hspa1a Fkbp4 Hsp90ab1 Dync1h1 Hspa1l Stip1 Dnaja4 Dnaja1 Hspa8 Dync1i2 Dync1i1 Hsp90aa1 Hspa2 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins Fbxo5 Psma4 Psma3 Psma6 Psma5 Plk1 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdk1 Cdc27 Skp1 Ube2d1 Psmb5 Cdc16 Nek2 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Psmb2 Fzr1 Btrc Skp2 Psma7 Psmc6 Rb1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Cdk2 Ccna1 Psmd7 Ccna2 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Cdc20 Mad2l1 Bub1b Aurka Cdc14a Pttg1 Aurkb Bub3 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 96%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs Fastkd2 Fastkd5 Tbrg4 NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 96%927802 Nonsense-Mediated Decay (NMD) Rps5 Rpl24 Dcp1a Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Ppp2r2a Upf1 Upf3a Eif4g1 Gspt2 Gspt1 Ppp2ca Rnps1 Smg1 Pabpc1 Smg9 Smg8 Smg7 Smg6 Smg5 Upf2 Magoh Etf1 Rps27 Rbm8a Upf3b Ppp2r1a Eif4a3 Casc3 Magohb Rps14 Rpl4 Rps16 Ncbp2 Rps18 Ncbp1 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 Pak1 Gngt1 Gngt2 Gng10 Gng3 Gng2 Gnb2 Arhgef6 Gnb1 Gng4 Gnb4 Gnb3 Gng7 Gnb5 Gng11 Gng8 Gng12 Gng13 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669936 Sorafenib-resistant KIT mutants Kit SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors Rnf2 Mbd1 Sumo3 Pias3 Pias4 Ube2i Ncor2 Pias1 Pcgf2 Trim28 Ddx5 Nrip1 Ep300 Ing2 Ring1 Cbx8 Phc2 Hipk2 Sin3a Phc1 Npm1 Cbx4 Cbx2 Park7 Ncoa2 Ncoa1 Phc3 Topors Ddx17 Casp8ap2 Uhrf2 Mrtfa Daxx Bmi1 Ctbp1 Ppargc1a Crebbp Safb DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 96%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) Slc4a1 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 96%1474228 Degradation of the extracellular matrix Col25a1 Col9a2 Col9a3 Ctsk Ctsl Mmp9 Col9a1 Cast Plg Adamts1 Lama5 Capn1 Adamts5 Capn2 Mmp14 Adamts4 Mmp16 Timp1 Timp2 Adamts8 Lamb3 Lama3 Capns1 Lamc1 Capns2 Ctsd Lamb1 Lamc2 Elane Adamts16 Ctsg Adamts18 Casp3 Optc Klk7 Tmprss6 Bmp1 Mmp24 Mmp25 Tll2 Tll1 A2m Mmp20 Mmp11 Mmp12 Mmp15 Mmp17 Mmp19 Mmp10 Phykpl Htra1 Capn9 Scube3 Capn8 Scube1 Capn5 Capn7 Capn6 Capn3 Hspg2 Tpsb2 Klkb1 Adam9 Adam8 Mmp8 Capn15 Spock3 Capn10 Capn11 Capn13 Mmp1a Bsg Mmp13 Dcn Cma1 Bcan Spp1 Mmp3 Cd44 Cdh1 Prss2 Adam15 Furin Ctrb1 Nid1 Adam10 Adam17 Col15a1 Col16a1 Col17a1 Col18a1 Col12a1 Col13a1 Col14a1 Psen1 Ctsb Ctss Col19a1 Ncstn Col26a1 Mmp2 Col23a1 Mmp7 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism Aprt Hprt1 Pnp Ada G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels Gng10 Kcnj3 Kcnj2 Gng3 Gng2 Gng4 Gng7 Gng8 Gabbr1 Gabbr2 Gngt1 Gngt2 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Gnb2 Gnb1 Kcnj10 Gnb4 Gnb3 Gnb5 Gng11 Kcnj12 Gng12 Gng13 Kcnj15 Kcnj16 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS Slc26a2 Slc26a1 Slc26a11 Slc35b3 Slc35b2 Papss2 Papss1 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Ephx2 Cyp1b1 Cyp2c50 Cyp1a2 Cyp2c65 Cyp2j6 Cyp1a1 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions Cyp2b10 Cyp2c50 Cyp2s1 Cyp2a5 Cyp2d22 Cyp2c65 Cyp2f2 Cyp2e1 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling Pak1 Wasl Tiam1 Rasa1 Hras Rhoa Grin2b Fyn Arpc1b Actr2 Arpc1a Actr3 Sdc2 Actg1 Actb Lyn Arpc3 Yes1 Arpc2 Grin1 Arpc5 Arpc4 Rock2 Rock1 Limk1 Limk2 Itsn1 Rac1 Ptk2 Arhgef28 Kalrn Cfl1 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) Rpa2 Xrcc1 Lig3 Aqr Rpa3 Polk Pole Xpa Cops4 Cops3 Cops6 Cops2 Ercc1 Ercc4 Ercc5 Cops8 Cops7a Uvssa Cops7b Znf830 Rbx1 Polr2c Ubc Cops5 Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2h4 Gtf2h3 Usp7 Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Ercc8 Ddb1 Lig1 Isy1 Cul4a Cul4b Rfc5 Pold2 Ell Pold1 Rfc3 Pcna Rfc4 Rfc1 Rfc2 Pold4 Pold3 Ercc6 Pole3 Pole2 Pole4 Tcea1 Xab2 Ppie Prpf19 Rpa1 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport Pnlip Apoe Lrat Apom Lrp10 Gpc1 Lrp12 Retsat Gpc3 Gpc2 Hspg2 Gpc5 Sdc4 Sdc3 Gpc4 Sdc2 Gpc6 Lrp1 Rdh11 Lrp2 Akr1c18 Bco2 Bco1 Ttr Apoa2 Ldlr Apoa4 Rbp4 Sdc1 Lpl Rbp2 Gpihbp1 Rbp1 Apoc2 Agrn Plb1 Akr1c21 Akr1b10 Apoc3 Apoa1 Akr1c6 Clps Apob TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 96%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation Tlr4 Mapk9 Mapk7 Mapk8 App Ikbkb Jun Peli1 Elk1 Ikbkg Map3k7 Ticam2 Traf2 Ticam1 Cd14 Map3k8 Nfkb1 Skp1 Fbxw11 Rela Btrc Casp8 Ubc Mapk1 Nfkbib Mapk3 Rps6ka3 Irak1 Nfkbia Mapkapk3 Rps6ka2 Traf6 Mapkapk2 Cul1 Ube2n Map2k7 Mapk14 Chuk Map2k6 Ppp2cb Ppp2ca Ube2v1 Trp53 Map2k4 Tab3 Map2k3 Tab2 Tab1 Mapk10 Map2k1 Mapk11 Ripk2 Myd88 Rps6ka5 Tlr9 Nkiras1 Atf2 Nkiras2 Rps6ka1 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Peli2 Ppp2r1a Peli3 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Tifa Dusp6 Alpk1 Irak2 Ager Nlrx1 Nfkb2 Mef2a Usp14 Usp18 Fos Tlr7 Ppp2r5d Ly96 Mef2c DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations Atrx Daxx RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.4 Response to elevated platelet cytosolic Ca2+ Scg3 Qsox1 Selp Lgals3bp Ppia Cyrib Sccpdh Srgn Wdr1 Maged2 Pecam1 Endod1 Aplp2 App Clec3b Mmrn1 Tgfb2 Habp4 Fn1 Plg Ttn Rarres2 Cdc37l1 Timp1 Plek Tagln2 Itih4 Itih3 Tgfb3 Vegfa Tuba4a Prkcb F5 F8 Alb Serpina1d Pfn1 A2m Apool Prkca Igf2 Igf1 Cap1 Cd36 Itga2b Actn2 Lamp2 Pcdh7 Cd9 Fgb Fga Vwf Abcc4 Tgfb1 Fgg Itgb3 Kng2 Prkcg Psap Aldoa Tln1 Vcl Actn1 Ppbp Hgf Cyb5r1 Pf4 Tf Serpine1 Hspa5 Pros1 Gas6 Egf Cd109 Nhlrc2 Phactr2 Stxbp2 Stxbp3 Tex264 Fermt3 Vti1b Brpf3 Lefty2 Chid1 Manf A1bg Pdgfb Islr Sparc Pcyox1l Apoh Hrg Gtpbp2 Ecm1 Ola1 Orm3 Ctsw Serping1 Calu Rab27b Selenop Lhfpl2 Actn4 Clu Sytl4 Ahsg Spp2 Vegfd Vegfc Vegfb Serpina3n Cd63 Timp3 Tor4a Cfd Fam3c Flna Serpinf2 Cfl1 Apoa1 Thbs1 F13a1 Tmx3 Anxa5 Stx4 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME%R-HSA-9924644.2 Developmental Lineages of the Mammary Gland Egf Tgfa Areg Prl Fgf10 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 96%9010642 ROBO receptors bind AKAP5 Prkar2a Prkaca Prkca Robo2 Ppp3cb Prkacb Akap5 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602410 TLR3 deficiency - HSE Tlr3 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 96%9614657 FOXO-mediated transcription of cell death genes Cited2 Foxo4 Pink1 Stk11 Foxo1 Nfyb Bcl2l11 Nfya Ddit3 Nfyc Fasl Crebbp Foxo3 Ep300 Bcl6 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters Slc26a2 Slc26a6 Slc26a1 Slc26a9 Slc26a7 Slc26a11 Slc26a4 Slc26a3 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 96%5669034 TNFs bind their physiological receptors Tnfrsf1b Tnfrsf1a Edar Tnfsf4 Tnfsf8 Tnfsf11 Fasl Cd27 Cd70 Tnfsf15 Tnfsf14 Tnfsf18 Tnfrsf11b Tnfrsf17 Tnfrsf18 Tnfrsf25 Tnfsf13 Tnfrsf13b Edaradd Lta Tnfrsf4 Tnfrsf8 Tnfsf13b Tnfrsf9 Eda2r Eda Tnfrsf14 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 96%168164 Toll Like Receptor 3 (TLR3) Cascade Mapk9 Mapk7 Mapk8 Irf7 App Ikbkb Jun Birc3 Birc2 Elk1 Traf3 Ikbkg Map3k7 Traf2 Ticam1 Ikbke Tank Map3k8 Nfkb1 Optn Skp1 Ube2d1 Fadd Fbxw11 Rela Ripk3 Btrc Casp8 Ripk1 Ube2d3 Ubc Mapk1 Nfkbib Mapk3 Rps6ka3 Irak1 Nfkbia Mapkapk3 Rps6ka2 Traf6 Mapkapk2 Cul1 Ube2n Map2k7 Mapk14 Chuk Map2k6 Ppp2cb Ppp2ca Ube2v1 Trp53 Map2k4 Tab3 Map2k3 Tab2 Tab1 Mapk10 Map2k1 Mapk11 Ripk2 Tbk1 Rps6ka5 Irf3 Nkiras1 Atf2 Nkiras2 Rps6ka1 Lrrc14 Vrk3 Ikbip Ppp2r1b Ppp2r1a Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 N4bp1 Dusp7 Tifa Dusp6 Alpk1 Irak2 Ager Nlrx1 Nfkb2 Mef2a Usp14 Usp18 Fos Tlr3 Ppp2r5d Mef2c SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 96%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) Cd274 Psma4 Cul3 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Spop Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Csnk2a2 Ccnd1 Psmc4 Psmc3 Cdk4 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Ywhag Adrm1 Sem1 Csnk2b SIGNALING BY MAPK MUTANTS%REACTOME%R-HSA-9652817.2 Signaling by MAPK mutants Mapk1 Dusp10 Dusp9 Dusp8 Dusp16 Dusp7 Dusp6 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 96%9706374 FLT3 signaling through SRC family kinases Fyn Flt3l Syk Lck Hck Flt3 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) Slc34a1 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) Kcnk18 ADENOSINE P1 RECEPTORS%REACTOME%R-HSA-417973.3 Adenosine P1 receptors Adora1 Adora2b Adora3 Adora2a MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%8851907 MET activates PI3K AKT signaling Pik3ca Gab1 Pik3r1 Hgf Met NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism Samhd1 Entpd1 Nt5e Entpd5 Gda Entpd2 Xdh Entpd6 Entpd3 Nudt16 Adprm Entpd7 Entpd8 Nudt5 Tymp Nt5c Nt5c1a Upb1 Agxt2 Dnph1 Upp1 Upp2 Dpys Dpyd Itpa Nt5m Nt5c2 Pnp Nudt15 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%392154 Nitric oxide stimulates guanylate cyclase Nos2 Kcnmb2 Gucy1a1 Pde2a Gucy1a2 Pde1b Pde1a Itpr1 Kcnmb4 Prkg2 Pde10a Nos3 Pde11a Kcnmb1 Kcnma1 Pde5a Pde9a Nos1 Irag1 Gucy1b1 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition Serpine1 Stt3b Cdh2 Pxn Sox2 Pxdn Edil3 Zeb1 Cdh1 Itga2 Gxylt2 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function Rbbp8 Brca2 Brca1 Rad51ap1 Brip1 Xrcc2 Dna2 Rad51c Rad51d Atm Blm Rad51b Bard1 Top3a Kat5 Exo1 Wrn Mre11a Nbn Sem1 Palb2 Rad51 Rad50 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME%R-HSA-9909505.2 Modulation of host responses by IFN-stimulated genes Uba7 Trim25 Rigi Ikbkb Ifi44l Isg15 Hspa5 Ube2l6 Ikbkg Ifi27 Eif2ak3 Arih1 Fkbp5 Atf6 Chuk Ifih1 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME DATABASE ID RELEASE 96%5658208 Defective SLC5A2 causes renal glucosuria (GLYS1) DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610783 Degradation of GLI2 by the proteasome Prkaca Gsk3b Csnk1a1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Prkacb Gli2 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Sufu Psmd1 Adrm1 Sem1 Cul1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-HSA-5654716.3 Downstream signaling of activated FGFR4 Fgf16 Frs2 Fgf15 Fgf18 Fgf2 Fgf1 Nras Gab1 Fgf4 Plcg1 Frs3 Fgf6 Sos1 Fgf9 Hras Fgf20 Ptpn11 Pik3ca Fgf23 Fgfr4 Pik3r1 Klb CELL DIVISION%REACTOME%R-HSA-68884.6 cell division Pds5b Pds5a Kif23 Kif20a Mau2 Rad21 Wapl Plk1 Smc1a Smc3 Stag2 Nipbl Stag1 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation Xrcc6 Psip1 Xrcc5 Hmga1 Xrcc4 Banf1 Lig4 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME DATABASE ID RELEASE 96%5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) Slc12a6 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME%R-HSA-5609978.5 Defective GALT can cause GALCT Galt RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation Cdc73 Rtf1 Leo1 Skic8 Aff4 Supt6 Iws1 Mllt3 Mllt1 Ctr9 Eaf1 Paf1 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Ell Nelfa Nelfb Nelfe Ctdp1 Ccnk Ncbp2 Ncbp1 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Eloa Eloc ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-HSA-983695.6 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Cd22 Stim1 Itpr3 Itpr2 Itpr1 Ptpn6 Sos1 Blnk Plcg2 Cd79a Fyn Nck1 Cd79b Pik3ap1 Btk Lyn Sh3kbp1 Blk Pik3cd Dapp1 Ahcyl1 Syk Vav1 Cd19 Pik3r1 Trpc1 Orai1 Orai2 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis Rpa2 Rbbp8 Sun2 Brca2 Brca1 H2bc9 Rpa3 H2bc7 H2bc8 Atm Tinf2 H2bc3 Smc1a H2ab2 H3c8 Psmc3ip Lmnb1 Mnd1 Mlh1 Mlh3 Spo11 H2bu2 Msh4 Dmc1 Msh5 Acd Terf2ip Cdk4 Cdk2 Terf2 Terf1 Hist2h2aa1 Smc3 Pot1 H2bc14 Rad21 H2ac20 Syce2 Syce3 Ube2i Syce1 Sun1 H2bc21 Tex12 Sycp1 H2bc26 Sycp2 Syne1 Fkbp6 Syne2 Sycp3 Stag3 Nbn Rec8 Smc1b Stag2 Stag1 H2ac12 Fignl1 H2ac11 Prdm9 H2ac15 H3c7 H2ax Rad51c Blm Hist1h2bp Top3a H2aj Mre11a Rad51 Rad50 Hspa2 Firrm Rpa1 PROTEIN HYDROXYLATION%REACTOME%R-HSA-9629569.1 Protein hydroxylation Riox2 Drg1 Kdm8 Drg2 Rwdd1 Jmjd4 F9 Jmjd6 Asph Rccd1 Etf1 Zc3h15 Ogfod1 Riox1 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface Slc11a1 Atox1 Atp7a Pdzd11 PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation Prkar2a Prkaca Prkar2b Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Prkar1a Prkacb Prkar1b DEFECTIVE CYP21A2 CAUSES AH3%REACTOME DATABASE ID RELEASE 96%5579021 Defective CYP21A2 causes AH3 Cyp21a1 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 96%8849468 PTK6 Regulates Proteins Involved in RNA Processing Ptk6 Sfpq Khdrbs1 Khdrbs3 Khdrbs2 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-HSA-8981607.3 Intracellular oxygen transport Cygb Ngb Mb REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%169911 Regulation of Apoptosis Pak2 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Oma1 Psmb5 Psmb4 Opa1 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Arhgap10 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) Kcnk16 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 96%5683371 Defective ABCB6 causes MCOPCB7 Abcb6 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins Magt1 Prmt1 Tmem258 Stt3a Canx Stt3b Srpk1 Srpk2 Ostc Ubc Tusc3 Dad1 Parp14 Parp16 Galnt1 Ddost Parp4 Parp6 Ganab Mgat5 Gsk3a Parp8 Zdhhc9 Gsk3b Man2a1 Parp10 Parp9 Zdhhc11 Mgat2 Mgat1 Mogs Csnk1a1 Golga7 Edem2 Fut8 St6galnac3 St6galnac4 St6galnac2 St3gal4 Mgat4c Ube2i Mgat4a St3gal2 Mgat4b St3gal1 Man1b1 Zdhhc20 Prkcsh St6gal1 Zdhhc8 Zdhhc5 Rpn2 Zdhhc3 Rpn1 Zdhhc2 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 96%192823 Viral mRNA Translation Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Grsf1 Rps25 Rps26 Rps21 Rpl39l Rps15a Dnajc3 Rps27l Rplp2 Rps27 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 96%2173782 Binding and Uptake of Ligands by Scavenger Receptors Hpx Colec11 Col4a1 Ambp Hp Jchain Scarf1 Apoe Col4a2 Prdx1 S100a9 Cd36 Stab2 Ssc5d Cd5l Calr Marco Msr1 Lrp1 Colec12 Scgb3a2 Scara5 Sparc Saa3 Cd163 Hyou1 Hba-a1 Stab1 Hbbt1 Ftl1 Hsp90b1 Fth1 Col3a1 Col1a2 Col1a1 Alb Hsp90aa1 Apoa1 Hsph1 Apob DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 96%5687613 Diseases associated with surfactant metabolism Slc34a2 Abca3 Sftpb Csf2rb2 Sftpd Csf2ra Sftpc Sftpa1 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.4 Negative regulation of FGFR1 signaling Ppp2cb Frs2 Ppp2ca Fgf2 Fgf1 Fgf4 Cbl Fgf10 Fgf3 Fgf6 Fgf9 Fgf20 Ubc Ptpn11 Fgf23 Fgf22 Mapk1 Braf Mapk3 Spry2 Ppp2r1a Mknk1 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Ccne1 Psmb2 Ccne2 Skp2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Ccnd1 Psmc4 Psmc3 Cdk4 Ubc Cdk2 Ptk6 Ccna1 Cks1b Psmd7 Ccna2 Psmd6 Cdkn1a Psmd8 Cdkn1b Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling Rasgrp1 Adora2b Ppp3r1 Ppp3ca Ppp3cb C3ar1 App Prkx Cdk5 Btk Prkacb Adcy3 Adcy4 Adcy1 Sct Adcy2 Adcy7 Adm Adcy8 Adcy5 Adcyap1 Adcy6 Ramp1 Gnaz Adcy9 Iapp Crhr1 Gnai2 Gnai1 Gipr Gnai3 Gip Calcrl Prkar1b Glp1r Crh Pth1r Gnat3 Prkar2b Cysltr2 Cysltr1 Calcr Ghrhr Gng10 Pth Gcgr Pth2 Glp2r Vipr2 Calca Vipr1 Gng3 Gng2 Gng4 Plcb4 Gng7 Ghrh Gng8 Pth2r Pthlh Gngt1 Gngt2 Camk2g Camk2d Ahcyl1 Gcg Adcyap1r1 Camk2b Camk2a Ramp3 Ramp2 Gnb2 Adm2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Vip Gng12 Gng13 Prkaca Itpr3 Itpr2 Camkk1 Itpr1 Camkk2 Mapk7 Prkcg Arhgef9 Gnal Rasgrf2 Gabbr1 Gabbr2 Rps6ka3 Rps6ka2 Ppp2cb Ppp2ca Tiam1 Rho Gnat1 Ppp2r1b Ppp2r1a Saa3 C3 Ppp2r5d C5 Avpr2 Sstr3 Oxtr Avpr1b Avpr1a Oxt Avp Plcb3 Plcb2 Plcb1 Prkca Gnat2 Akt3 Akt2 Akt1 Prkar1a Mchr1 Adora2a Camk4 Pdyn Galr2 Galr3 Galr1 Fpr1 Tas1r2 Tas1r1 Tas1r3 Pnoc Tas2r131 Tas2r135 Tas2r137 Tas2r136 Gpr18 Tas2r140 Gpbar1 Tas2r4 Fpr-s1 Ptger4 Ccr5 Tas2r7 Ptger2 Ptger3 Mtnr1a Mtnr1b Agtr2 Vav1 Gpha2 Gpr37 Pik3r5 Pik3r6 Gpr31 Pik3r1 Rgr Pik3r2 Ptgdr2 Cx3cl1 Ccl28 Ccl25 P2ry13 Pak1 P2ry12 Ccl20 Gpr55 P2ry14 Lhcgr Oxgr1 Sucnr1 Psap P2ry4 Ccl5 Ccl4 Ccl2 Ccl1 Rrh Ptgdr Apln Tas2r39 Oprd1 Tas2r38 Sstr5 Sstr4 Sstr2 Sstr1 Gpr183 Lhb Ppbp Ccr10 Tas2r16 Cx3cr1 Tas2r13 Ppy Gpr15 Ccr1 Pik3cg Gpr25 Npbwr1 Gpr27 Fshb Gpr20 Mc2r Gpr45 Fshr Pf4 Gpr84 Ccr9 Gpr83 Ccr8 Pik3ca Pde10a Ccr7 Pde11a Ccr6 Gpr176 Ccr4 Ccr3 Gpr150 Ccr2 Pde7b Crhr2 Pde7a Gal Rgs8 Pde8a Pde8b Pcp2 Pdpk1 Grk6 Penk Gpsm3 Npb Gpsm2 Opn1mw Gpsm1 Npw Pde3a Ppp1r1b Tas2r40 Pde2a Tas2r41 Pde4a Hcar1 Rgs20 Hcar2 Rgs22 Cxcr1 Rgs14 Cxcr2 Pde4c Npy1r Pde4d Cxcr3 Rgs10 Rgs12 Cxcr5 Itga5 Cxcr6 Oprl1 Rhoa Cxcl11 Hebp1 Arhgef18 Cxcl10 Opn1sw Aplnr Opn3 Gper1 Opn5 Pyy Adora1 Adora3 Cxcl16 Cxcl13 Mcf2l Tas2r119 Npy5r Grm3 Grm2 Grm4 Arhgef16 Grm7 Grm8 Npy4r Ptgir Tas2r120 Tshr Cxcl9 S1pr3 Cxcl1 S1pr2 S1pr5 Cxcl2 S1pr4 Cxcl3 Cxcl5 Arhgef26 Tas2r107 Itsn1 Gpr37l1 Npy2r Itgb1 Ackr3 Cnr1 Kalrn Cnr2 Cort Prex1 Trio Anxa1 Mcf2 Rgs9 Rgs6 Rgs7 Mgll Ppp1ca Npy Gna11 Gna15 Gna14 Gnaq Cxcr4 Cxcl12 Ednra Rgs11 Npff Trhr Rgsl1 Gnrh1 Nmbr Fpr2 Ptgfr Agtr1a Nmb Lpar6 Xcr1 Lpar5 Ppan Grpr Gpr17 Nms Nmu Cckar Nmur2 Sos2 Gnrhr Nmur1 Ntsr2 Ntsr1 Brs3 Ptger1 Gpr132 Edn2 Prkar2a Cckbr F2 Hcrt Grp Kiss1r Nps Ptafr Npffr1 Npffr2 Gprc6a Prok2 Gpr4 Qrfp Prok1 Npsr1 Agt P2ry10 F2rl1 Gast F2rl2 F2rl3 Prokr2 Ghsr Prokr1 Rgs4 Rgs5 Rgs2 Rgs3 Gpr65 Rgs1 Gpr68 Uts2 Tacr1 Tacr3 Tacr2 Casr F2r Ffar3 Ffar4 Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng2 Grk5 Tac3 Tac1 Opn4 Pmch Ltb4r1 Ltb4r2 Hbegf Trh Grm1 Grm5 Lpar4 Lpar3 Lpar2 Lpar1 Mmp3 Qrfpr Xcl1 Kiss1 Rgs21 Rgs17 Rgs18 P2ry6 Rgs19 Rgs13 P2ry2 Rgs16 P2ry1 Hcrtr2 Hcrtr1 Uts2b Cck Uts2r Egfr Adra2a Adra2c Adra2b Pde3b Pla2g4a Grk2 Pde1b Pde1c Prkcd Sst Pde1a C5ar1 Trpc6 Trpc7 Trpc3 Grk3 Prkcb Prkcq Oprm1 Rasgrp2 Ednrb Daglb Dgka Dgkb Edn1 Abhd6 Edn3 Dgke Abhd12 Dgkg Dgkh Dgki Mc1r Dgkk Rps6ka1 Dgkq Prkch Dgkz Mc5r Dagla Prkce Rxfp3 Rln3 Rxfp2 Rxfp1 Mc4r Rln1 Pomc Insl3 Rxfp4 Insl5 Rhob Arhgef17 Arhgef11 Arhgef10 Mc3r Akap13 Arhgef25 Arhgef3 Arhgef2 Oprk1 Cga Arhgef1 Ect2 Tshb Arrb2 Vav3 Arrb1 Net1 Arhgef10l Vav2 Tiam2 Rhoc Plxnb1 Arhgef15 Arhgef19 Ngef Adra1b Adra1a Adra1d Gna12 Arhgef7 Arhgef6 Tbxa2r Arhgef4 Gna13 Fgd2 Fgd1 Fgd4 Arhgef37 Fgd3 Arhgef39 Arhgef38 Arhgef40 Plekhg5 Src Plekhg2 Rock2 Rock1 Mapk1 Mapk3 Gpr143 Htr4 Chrm1 Hrh1 Chrm3 Htr6 Chrm2 Htr7 Chrm5 Hrh4 Chrm4 Hrh2 Htr2a Nras Htr2c Htr2b Drd1 Adrb2 Sos1 Adrb1 Drd3 Hras Abr Drd4 Drd5 Adrb3 Taar8b Htr1d Taar6 Htr1f Taar9 Taar2 Taar5 Htr1b Taar1 Htr5a Ppp3cc SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine Gfpt1 Amdhd2 Gfpt2 Gnpnat1 Renbp Pgm3 Uap1 Nagk TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-HSA-5656169.2 Termination of translesion DNA synthesis Uba7 Rpa2 Rpa3 Polk Polh Pole Isg15 Pclaf Usp43 Rev1 Usp10 Poli Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Trim25 Rfc1 Rfc2 Pold4 Pold3 Pole3 Pole2 Ubc Pole4 Ube2l6 Rpa1 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation Mkrn1 Rcor1 Psma4 Jun Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Xiap Kdm1a Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Mta1 Psma7 Mta3 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Stub1 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Trp53 Rnf146 Pparg Tnks2 Tnks Trim27 Hdac1 Otud3 Wwp2 Usp13 Frk Akt3 Akt2 Akt1 Mov10 Chd3 Chd4 Ago4 Ago3 Mecom Nr2e1 Ago2 Ago1 Ezh2 Rest Snai2 Csnk2a2 Suz12 Mta2 Sall4 Gatad2a Gatad2b Mbd3 Ring1 Cbx8 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Mapk1 Mapk3 Bmi1 Atn1 Maf1 Rptor Csnk2b Eed Rnf2 Usp7 Slc38a9 Lamtor5 Lamtor4 Rraga Mlst8 Rragb Lamtor1 Rragc Lamtor2 Rragd Mtor Hdac2 Hdac5 Hdac7 Tnrc6c Rbbp4 Rbbp7 Atf2 Tnrc6a Tnrc6b Egr1 Pten Hdac3 Nedd4 Snai1 Pml DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 96%5632968 Defective Mismatch Repair Associated With MSH6 Msh6 Msh2 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking Nos3 Cav1 Wasl Nostrin Dnm2 HATS ACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%3214847 HATs acetylate histones Actl6a H2bc9 H2bc7 H2bc8 H2bc3 Ruvbl2 Phf20 Ruvbl1 Actb Hcfc1 Ing5 Kat8 Yeats2 H2bu2 Kat14 Atxn7 Dr1 Tada3 Trrap Tada2a H2bc18 Zzz3 Mbip Kansl3 Kansl1 Kansl2 Kat2b Kat2a Hist2h2aa1 Ep400 Yeats4 Sgf29 Ogt Sap130 Wdr5 H2bc14 H2ac20 H2bc21 Meaf6 H2bc26 Pax3 Kat5 Rbbp7 Atf2 Brpf3 Brpf1 Kat6a Supt20 Ep300 Vps72 Ing4 Ing3 Clock Kat7 H2ac12 Supt3 H2ac11 Msl2 Msl3 Msl1 Taf12 Hat1 Eny2 H2ac15 H2ac21 Ncoa2 Jade1 H3c7 Ncoa1 Jade2 H2ac25 Brd8 Hist1h2af Jade3 Morf4l2 Morf4l1 H2ac1 Supt7l Taf9 Taf5l Mrgbp Taf6l Dmap1 Epc1 Hist1h2bp Elp2 Elp1 Elp4 Usp22 Tada1 Elp3 Elp6 Elp5 Crebbp PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 96%6811555 PI5P Regulates TP53 Acetylation Pip4p1 Trp53 Pip4k2b Pip4k2a Pin1 Ep300 Ing2 Map2k6 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 96%4839744 Signaling by APC mutants Ppp2cb Ppp2ca Gsk3b Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM Slc34a2 COX REACTIONS%REACTOME DATABASE ID RELEASE 96%140180 COX reactions Ptgs1 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3645790.4 TGFBR2 Kinase Domain Mutants in Cancer Tgfb1 Tgfbr1 Tgfbr2 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 96%3371511 HSF1 activation Rpa2 Hdac6 Vcp Ywhae Hsbp1 Rpa3 Hsp90aa1 Hsf1 Rpa1 Hsp90ab1 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) Rhag METABOLISM%REACTOME%R-HSA-1430728.16 Metabolism Cyb5a Slc23a1 Cyb5r3 Slc23a2 Angptl4 Ldlrap1 Amn B3gnt5 Nr1h3 Prkacb Apoa2 Ldlr Apoa4 Apoa5 Lpl Gpihbp1 Ces3b Apoc2 Vdac1 Abca1 Alb Apoc3 Sacm1l Cubn Pi4k2b Mtmr2 Idh1 Chst11 Pi4ka Chst12 Sbf1 Glce Chsy1 Nhlrc1 Uxs1 Chsy3 Chst13 Eno3 Chst14 Eno2 Chst15 Eno4 Phka1 Phka2 Ndst1 Ndst2 Galt Ndst3 Ndst4 Omd Hspg2 Slc35d2 Sdc4 Sdc3 Sdc2 Hs3st3b1 Gns Abo B4galt4 B4galt5 Ppp1r3c B4galt6 B4galt7 Pck2 Slc26a11 Pgm2l1 B4gat1 B4galt1 B4galt2 B4galt3 Ext2 Ext1 Sdc1 Akr1a1 Xylb B3gnt7 Gbe1 B3gnt4 Man2c1 Slc25a17 B3gnt2 Cyp11a1 Khk Gys1 Manba Gys2 Pgam2 Pgam1 Akr1b1 Tpi1 Rab14 Gaa Man2b2 Man2b1 Chst1 Chst3 Chst2 Chst5 Dera Chst7 Hyal5 Hyal2 Tkt B3galt2 Pcx Pitpnb B3galt1 Aldob Aldoc Aldoa Rhd Glyctk Has1 Gpc1 Stab2 EG433182 Gpc3 Gpc2 Has2 Gpc5 Has3 Carnmt1 Gpc4 Fmod Hal Gpc6 Aoc1 Cd44 Uroc1 Slc17a5 Hdc Pygb Amdhd1 Agl Carns1 Pygl Ftcd Pygm Hnmt Hs6st3 Cyp4f14 Hs6st2 Ptgis Hs6st1 Tbxas1 Epm2a Cyp8b1 Stard3nl Lyve1 Stard4 Akr1e2 Stard3 Papss2 Star Papss1 Gnpda1 Tspo Aldh1a1 Extl2 Naglu Gnpda2 Kera Extl3 Shpk Csgalnact1 Slc37a4 Chpf Agrn St6galnac6 Gyg1 Csgalnact2 Slc37a1 Chp1 Pgd B3galt6 B3galt5 B3galt4 Gckr Slc26a2 Slc26a1 Phkb Fut2 Fut1 Cemip Fam20b Fut4 Galk1 Fut7 Fut9 Hpse Pgk2 Hs2st1 Thrap3 Cryl1 Fam120b Pxylp1 Hk2 Hk1 Hk3 G6pc2 G6pc3 Ust Ogn Slc35b3 Slc35b2 Sord Pfkfb4 Pfkfb3 Pfkfb1 Dse Pgm2 Slc2a1 Pgm1 Rbks Hsd3b6 Cyp21a1 Phkg1 Phkg2 Hsd3b1 Hkdc1 Cyp11b2 Hmmr Hsd17b10 Hs3st3a1 Lalba Prps1l1 Prps1 Prps2 Tkfc Dsel Fbp1 Fbp2 Hs3st4 Hs3st1 Hs3st2 Hs3st5 Rpe Taldo1 Hs3st6 Bpgm Rpia Pfkl Gale B4galnt2 Hpse2 B3gat3 B3gat1 B3gat2 Galm Prelp Ugp2 Pfkm Pfkp St3gal6 Galns Lum Sgsh Adpgk Xylt1 Xylt2 Dcxr Pgls Tph1 Adh4 Aldh1b1 Acss2 Adh1 Aldh2 Adh7 Acss1 Adh5 Ucp1 Elovl3 Cidea Dguok Gmpr Adk Dck Aprt Adal Gmpr2 Pnp Ampd3 Ampd2 Ampd1 Ada Parp14 Parp16 Parp4 Parp6 Parp8 Parp10 Parp9 Plcb3 Plcb2 Plcb1 Prkca Prkg2 Maoa Cacna1c Prkar1a Aldh4a1 Prodh Prodh2 Slco1a4 Pdhx Ldhal6b Glo1 Gpt Wdr26 Pdha1 Pdha2 Mpc1 Mpc2 Pdk4 Nek1 Pdk3 Mkln1 Pdk2 Pdk1 Pdhb Pdp1 Fahd1 Pdp2 Pdpr Gid4 Maea Ldha Ldhb Gid8 Ldhc Armc8 Me3 Dlat Me2 Rmnd5a Rmnd5b Sirt4 Ttr Oxa1l Prss2 Ces1d Inpp5e Shmt2 Arf3 Pikfyve Gde1 Pi4k2a Sbf2 Plekha8 Plekha6 Plekha5 Inpp4a Inpp4b Plekha3 Plekha2 Plekha1 Tpte Tnfaip8l2 Mtmr10 Letm1 Tnfaip8l3 Gdpd5 Tnfaip8l1 Mtmr14 Gdpd3 Ndufa5 Mtmr12 Gdpd1 Pld1 Rufy1 Inpp5f Vapb Pi4kb Pnpla6 Enpp6 Inpp5k Mtm1 Pnpla7 Pik3c2b Bmx Pik3c2g Fig4 Vac14 Mtmr3 Mtmr1 Tnfaip8 Mtmr7 Mtmr6 Pip5k1b Mtmr9 Gk Pip5k1a Plin3 Pnpla5 Ippk Plin1 Abhd5 Ppip5k1 Mgll Ppip5k2 Ppp1ca Nudt4 Fabp1 Nudt3 Ip6k1 Ppp1cb Nudt11 Fabp2 Ip6k3 Fabp3 Fabp4 Fabp5 Fabp6 Fabp7 Mogat1 Lpin3 Gpat2 Lpin2 Lpin1 Mogat2 Gk2 Fabp12 Dgat2 Dgat1 Lipe Stxbp1 Gpd2 Fabp9 Akap5 Aloxe3 Gpx4 Alox12b Ckb Prkar2a Srd5a3 St6galnac5 Ctsa St8sia5 Neu2 Neu3 Neu1 St3gal5 Ddc Pnmt Th Dbh Arf1 M6pr Dnm2 As3mt Ahcy Nnmt Mtrr Trmt112 Mat2a Mtr Hemk2 Comt Gsto1 Mat2b Mat1a Adra2a Adra2c Pik3c3 Acbd5 Pik3r4 Abcc2 Eci1 Acadm Decr1 Pex11a Elovl5 Cidec Acsl1 Pnpla2 Thrsp Nr1h4 Akr1c21 Hsd3b7 Cyp27a1 Akr1d1 Cyp7a1 Cyp7b1 Akr1c6 Tcn2 Fech Uros Ppox Cox10 Alad Alas1 Alas2 Hmbs Cox15 Cpox Urod Rbp4 Rbp2 Rbp1 Gss Ocrl Lrat Slc2a2 Plpp6 Hsd17b7 Nsdhl Dhcr24 Ebp Arv1 Msmo1 Acat2 Ltc4s Entpd1 Nt5e Entpd5 Ggt1 Plcg2 Awat2 Dpep1 Dpep2 Lrp1 Ggt5 Bco2 Bco1 Adcy3 Cyp4v3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Gnai2 Gnai1 Prkar1b Prkar2b Wasl Hsd17b1 Apom Retsat Inpp5d Plcb4 Itpka Synj1 Inpp5b Itpkc Itpkb Plcz1 Plch2 Plch1 Pld4 Plce1 Plcd1 Plcd4 Plcd3 Itpk1 Inppl1 Pm20d1 Akr1b10 Lrp10 Lrp12 Olah Hsd17b8 Hsd17b3 Acly Elovl4 Hacd1 Morc2a Hsd17b12 Elovl1 Hacd2 Ecsit Hacd3 Elovl7 Hacd4 Cbr4 Tecrl Tecr Acsbg1 Acsbg2 Acsl5 Ppt2 Acsl6 Acsl3 Slc27a3 Ppt1 Acsl4 Acsf3 Mboat7 Miox Inpp5a Cpt1a Impa2 Impa1 Isyna1 Inpp1 Agk Csnk1g2 Nos3 Osbpl1a Fads2 Fads1 Cyc1 Uqcrq Lyrm7 Hscb Uqcrc2 Uqcrc1 Lyrm4 Uqcrfs1 Uqcc2 Uqcc3 Uqcrb Uqcc1 Uqcc6 Uqcr10 mt-Cytb Fxn Bcs1l Ttc19 Uqcrh Inmt Eefsec Gnmt Scly Sars1 Sepsecs Sephs2 Secisbp2 Nudt16 Pstk Adprm Slc10a2 Nudt5 Slc10a1 Stard5 Slc27a5 Slc51a Slc51b Gch1 Pdss2 Coq8a Coq8b Pdss1 Coq2 Coq3 Pts Gchfr Coq4 Coq5 Coq6 Hpdl Coq7 Spr Coq9 Stard7 Ugt1a2 Zdhhc21 Cda Gda Entpd2 Umps Entpd6 Entpd3 Cyp2u1 Cyp1b1 Entpd7 Entpd8 Cyp4a32 Gart Cyp4f15 Cad Atic Dnph1 Adsl Pudp Uckl1 Itpa Dhodh Adss2 Pfas Adss1 Ppat Tk2 Uck1 Uck2 Paics Ncoa3 Nt5c2 Ugt2a1 Ugt2a2 Ugt2a3 Ugt2b1 Ugdh Ranbp9 Slc35d1 Ugt1a6 Ugt1a9 Ugt3a2 Ugt1a5 Abhd10 Ugt1a1 Nat1 Nat2 Ugt2b38 Ugt2b36 Ugt2b34 Ptgds Mfsd2a Phospho1 Pcyt1b Pcyt1a Abhd3 Pemt Chpt1 Pctp Stard10 Hadha Cept1 Hadhb Acadl Chka Chkb Cygb Cyb5b Slc6a11 Lypla1 Ddah1 Smpd2 Smpd3 Glul Ache Ttpa Cacna2d2 Cacnb3 Cacnb2 Bche Cacna1e Cacna1a Ppa2 Chat Oxct2a Hmgcl Bdh2 Bdh1 Oxct1 Hmgcll1 Hmgcs2 Acat1 Aacs Slc45a2 Slc6a7 Oca2 Dct Tyrp1 Tyr Rgl1 Smpd1 Cds1 Cdipt Pitpnm3 Pitpnm1 Acoxl Pla2g4a Mecr Slc25a27 Ucp2 Ucp3 Lgmn Slc25a14 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Acsm1 Vdr Nr1h2 Rora Ppara Pparg Pias4 Rxra Cyp19a1 Ube2i Pxmp2 Cox19 Cox17 Aco2 Pold1 Cs Brip1 Timm21 Tafazzin Idh3g Vapa Ndufb8 Aldh6a1 Bcat1 Bcat2 Acad8 Hibadh Slc25a44 Rtel1 Acadsb Tiam2 Gcsh Ndufab1 Acot8 Hsd17b4 Ehhadh Acaa1a Slc27a2 Abcd1 Decr2 Acot4 Rap1a Mapkapk2 Chrm3 Folr2 Slc25a15 Arg1 Nags Asl Cps1 Nmral1 Ass1 Otc Ncor1 Slc46a1 Helz2 Carm1 Ep300 Tbl1x Hmox1 Clock Bmal1 Hdac3 Ncoa2 Ncoa1 Tbl1xr1 Smarcd3 Ncoa6 Npas2 Med1 Nr1d1 Ppargc1a Crebbp Apoa1 Chd9 Apob Slc44a3 Slc44a4 Slc44a5 Etfb Slc44a1 Slc44a2 Bst1 Glp1r mt-Nd4 mt-Nd5 mt-Nd6 mt-Nd1 Gng10 mt-Nd2 mt-Nd3 Gcgr Ptpmt1 Pisd Pcyt2 Abhd4 Osbpl10 Gng3 Lpgat1 Gng2 Pla2g15 Pgp Mboat1 Gng4 Cpne1 Osbpl5 Gng7 Cpne3 Pla1a Osbpl8 Gng8 Pgs1 Dgat2l6 Cpne6 Cpne7 Selenoi Glyatl3 Acsm2 Crls1 Acsm4 Cds2 Gpcpd1 Acsm5 Gngt1 Pnpla3 Glyat Etnppl Gngt2 Plaat1 Plaat5 Etnk1 Gcg Gnb2 Mpst Gnb1 Sqor Gnb4 Mri1 Gnb3 Gnb5 Suox Ado Gng11 Txn2 Mtap Gng12 Bhmt Gng13 Csad Cbs Bhmt2 Tstd1 Got1 Got2 Ethe1 Fmo1 Apip Enoph1 Adi1 Tst Cth Gadl1 Cdo1 Slc25a10 Hexa Hexb Idua Ncan Bgn Cspg5 Cspg4 Dcn Bcan Vcan Mcee Glb1 Hyal4 Pcca Hyal3 Mmaa Pccb Ids Hyal1 Mmut Naalad2 Glb1l3 Aspg Glb1l2 Arsb Aspa Gusb Nat8l Mmab Mmadhc Mmachc Nrf1 Alox5ap Alox15 Cyp4f39 Cyp4f17 Abcc1 Cyp24a1 Cyp4a12b Nup37 Cyp4f3 Cyp4f40 Shmt1 Nup160 Cyp4b1 Ptgr1 Pdxk Ppp2cb Slc52a2 Naxe Ppp2ca Slc52a3 Nup43 Ubiad1 Btd Ctrb1 Slc25a51 Cd320 Ranbp2 Slc19a1 Slc19a2 Slc5a8 Cblif Mthfr Vkorc1 Slc25a32 Thtpa Mthfd1l Naprt Rfk Acp5 Nup107 Aox1 Nadk2 Nudt12 Mthfd2l Nmrk2 Rps27 Nmrk1 Mocs3 Slc25a19 Mocs2 Aldh1l1 Ppp2r1b Hlcs Ppp2r1a Nadsyn1 Aldh1l2 Cd38 Pnpo Nadk Nmnat1 Flad1 Slc22a13 Vkorc1l1 Nmnat3 Nmnat2 Tpk1 Mthfsl Nup85 Qprt Mthfd1 Mthfd2 Gphn Mocos Ppa1 Lhpp Ppp2r5d Sec13 Ppp1cc Cyp2r1 Aanat Tph2 Nup133 Pla2g2e Pla2g2d Pla2g2f Pla2g4d Ptdss1 Gpd1l Ptdss2 Lpcat4 Pld2 Pla2g12a Acp6 Pla2g5 Lclat1 Gnpat Gpat4 Pla2g1b Gpat3 Pla2r1 Liph Miga2 Agpat5 Pla2g10 Ces2h Miga1 Lpcat1 Gpd1 Ddhd1 Agpat3 Agpat4 Agpat1 Agpat2 Nmt2 Adipor2 Ercc2 Adipor1 Adipoq Mlxipl Phykpl Asah1 Fdx1 Fdxr Fdx2 Trib3 Prkaa2 Akt1 Plin2 B3gnt3 Csnk2a2 Nmt1 Pik3r5 Pik3r6 Slc22a4 Pik3r1 Pik3r2 Echs1 Acsm3 Acads Hadh Rab5a Pik3cg Pik3cb Pik3cd Ca1 Prkag2 Ca2 Pik3ca Ca4 Csnk2b Them4 Smim20 Suclg1 Nubpl Kcng2 Suclg2 Cmc1 Tmem223 Isca2 Sco1 Coq10a Etfdh Coq10b Rab5if Trap1 Sdhaf1 Sdhaf2 Sdhaf3 Sfxn4 Sdhaf4 Prkab2 Surf1 Higd2a Ndufa12 Kcnb1 Ndufa10 Nnt Timmdc1 Ndufa13 Ndufb11 Kcns3 Ndufb10 Fh Hccs Lyrm2 Dmac2 Dmac1 Kcnc2 Ndufaf7 Ndufaf6 Ndufaf5 Tmem186 Ndufaf4 Ndufaf8 Sdhd Sdhc Ndufaf3 Sdhb Sdha Ndufaf2 Ndufaf1 Tmem126b Tmem126a Acad9 Cox20 Taco1 Coa3 Idh2 Cox11 Cox14 Ndufv2 Ndufv1 Ndufv3 Cox16 Cox18 Tmem177 Ndufc1 Ndufc2 Ndufs1 Ndufs2 Ndufs5 Acadvl Ndufs7 Ndufs8 Foxred1 Gba1 Ndufa1 Ndufa3 Ndufa2 Ndufa7 Ndufa6 Ndufa9 Ndufa8 Sucla2 Ndufb2 Idh3a Ndufb3 Ndufb6 Etfa Ndufb5 Ndufb7 Idh3b Ndufb9 Hgd Tat Fah Hpd Sphk1 Gna11 Gna15 Gna14 Cyp39a1 Gapdhs Por Cyp11b1 Cyp27b1 Cyp46a1 Gnaq Slc27a1 Ggt7 Akr7a2 Ggt6 Acy3 Mgst3 Mgst2 Trp53 Mgst1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Slc25a4 Rps14 Agt Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Kpnb1 Rps11 Rpl7 Hsp90aa1 Rpl32 Rps9 Rps7 Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Ffar1 Rps25 Rps26 Rps21 Rpl39l Rps15a Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Dhrs7b Rpl11 Glud1 Rps3 Rps4x Sirt5 Gc Ran Slc5a6 Pdzd11 Aasdhppt Enpp1 Enpp2 Enpp3 Ogdh Pank3 Dlst Pank2 Srd5a1 Hibch Pank4 Srd5a2 Vnn1 Cyp17a1 Mccc1 Auh Slc25a16 Ivd Vnn3 Mccc2 Ppcs Ppm1k Pank1 Fasn Tpst1 Dcakd Ppcdc Tpst2 Slc25a42 Coasy Sumf1 Rida Sds Sumf2 Sdsl Arsa Arsk Arsj Arsi Arsg Glipr1 Ptges2 Ormdl3 Pik3c2a Synj2 Gm2a Lrp2 Pip5k1c Mdh1 Mdh2 Slc25a18 Slc25a11 Slc25a22 Slc25a12 Slc25a13 Aldh3b1 Degs1 Phyh Amacr Hacl1 Gstk1 Lars1 Crot Gla Scp2 Eef1e1 Paox Crat Kars1 Acox2 Nudt19 Acot2 Acox3 Pipox Baat Ddo Mars1 Agps Hao1 Agxt Hao2 Nudt7 Dars1 Pecr Qars1 Dao Ephx2 Rars1 Pomc Aimp2 Aimp1 Eprs1 Iars1 Med9 Duox1 Duoxa1 Cdk19 Duoxa2 Med13l Cav1 Dio1 Txndc11 Dio2 Acbd4 Dio3 Serpina6 Hsd11b1 Duox2 Hsd11b2 Tpo Iyd Dmgdh Cga Sardh Aldh7a1 Slc5a5 Chdh Tshb Fmo3 Nudt15 Fmo2 Mfsd2b Tpmt Sgpl1 Impdh1 Prkd3 Gmps Sptssa Nme2 Hprt1 Sptssb Nme1 Prkd1 Prkd2 Cers6 Plpp2 Gstm2 Cers5 Guk1 Abcc5 A4galt Gba2 Plpp3 Cers4 Cers3 Plpp1 Xdh Cers2 Asah2 Sgms1 Sgms2 Sptlc1 Cerk Sptlc2 Sptlc3 Fa2h B3galnt1 Sphk2 Kdsr Ugcg Lass1 Smpd4 Hsp90ab1 Enpp7 Galc B4galnt1 Ormdl1 Ugt8 Acer1 Acer2 Gal3st1 Acer3 Ormdl2 Degs2 Samd8 Ppm1l Osbp Sgpp2 Sgpp1 Ch25h Hsd17b11 Hsd17b14 Osbpl3 Osbpl2 Osbpl7 Osbpl6 Osbpl9 Hsd17b2 Med22 Med21 Akr1b8 Med28 Med29 Med11 Marcks Med19 Ipmk Med18 Minpp1 Syt5 Pgk1 Mlx Stk11 Ckmt1 Acy1 Ckmt2 Tdo2 Afmid Hoga1 Snap25 Ido2 Acmsd Ido1 Pycr3 Vamp2 Pycr2 Stx1a Pycr1 Kyat3 Oaz1 Oaz3 Oaz2 Dhtkd1 Fdft1 Gldc Insig1 Hykk Insig2 Phgdh Ggps1 Aadat Sc5d Scd1 Agmat Slc25a21 Sar1b Gcdh Lss Tm7sf2 Slc6a8 Arg2 Sec23a Pmvk Aass Mtf1 Oat Scap Odc1 Gatm Mvd Acacb Bbox1 Acaca Ckm Fdps Slc25a2 Idi1 Aldh9a1 Sat1 Mvk Serinc4 Nfyb Serinc5 Nfya Serinc2 Nfyc Serinc3 Sec24d Serinc1 Sec24c Haao Mbtps1 Kmo Mbtps2 Sec24b Grhpr Sqle Azin2 Sec24a Psph Gpam Azin1 Rimkla Sp1 Rimklb Cyp51a1 Elovl6 Amt Dhcr7 Crym Srebf2 Psat1 Srm Srr Tmlhe Kynu Alox12 Sult1e1 Sult1a1 Abhd14b Sult1b1 Podxl2 Bpnt2 Sult6b1 Sult4a1 Sult2a1 Bpnt1 Slc22a5 ATP6 Atp5f1d Far2 Atp5pb Far1 Mcat Atp5f1c Atp5pf Acad11 Acad10 Alox8 G0s2 Ptgr2 Atp5mc3 Slc25a20 Acot3 Atp5mf Acot9 Acot7 Hspa9 Ptgs1 Atp5me Dmac2l Tnfrsf21 Ptpn13 Ankrd1 Atp5f1b Atp5f1a Hsd17b13 Fitm2 Atp5mk Cd36 Fitm1 Hilpda Awat1 Fhl2 Them5 Cpt1b Ptges Mid1ip1 Faah Prxl2b Acot11 Acot12 Acot13 Cbr1 Grhl1 Acaa2 Acbd6 Acbd7 Acsf2 Dbi Cpt2 Pon3 Pon1 Pon2 Abcc3 Ahcyl1 Gclc Gclm Me1 Blvrb Blvra Prkaca Gsta3 Kcnj11 Itpr3 Itpr2 Nqo1 Itpr1 Adhfe1 L2hgdh D2hgdh Txn Plcg1 Nostrin Alox5 Ptgs2 Abcc8 Ip6k2 Ephx1 Aadac Bphl Aldh3a1 Cbr3 Car12 Clps Car14 Glrx5 Ca13 Pnlip Ca3 Mtarc2 Samhd1 Mtarc1 Ca5b Ca5a Slc25a37 Alpi Slc25a28 Aoc3 Aoc2 Cmbl Nqo2 Car7 Car6 Nosip Rab4a Slc36a4 Slc3a2 Pla2g4f Pla2g4c Pla2g4e Lpcat3 Lpcat2 Slc7a5 Plbd1 Plb1 Tmem86b Pnpla8 Plaat3 Pla2g3 Pla2g6 Mboat2 Slc6a12 St3gal4 St3gal2 St3gal1 Tyms Dhfr Tk1 Gamt Gls Med8 Med4 Med6 Pip4k2b Pip4k2a Higd1c Psap mt-Co2 mt-Co3 Gpi Ppard Lhb Gps2 Coxfa4 Cdk8 Sin3a Lbr Gpx2 Gls2 Cox7a1 Cox7a2 Ins2 Cox7a2l Cacna1d Havcr2 Esrra Qdpr Pah Asrgl1 Pcbd1 Kyat1 Il4i1 Mtmr4 Gstz1 Gsta5 Chac1 Chac2 Gstm7 Gstm5 Gstm4 Gstm1 Gsto2 Esd Cndp2 Hpgds Gstt2 Gstt1 Nampt Oplah Ndor1 Mms19 Nubp2 Ciao1 Nubp1 Ciao2b Ciao3 Ciapin1 Med23 Med24 Med25 Med20 Med26 Med27 Med12 Med13 Med14 Med10 Med15 Med16 Med17 Ncor2 Srebf1 Cox6a1 Cox6a2 Med30 Med31 G6pc1 Cox6b1 Cox6b2 Rrm2b Slc2a3 Arnt G6pdx Pten Rapgef4 Rapgef3 Ccnc Pck1 Pip4p1 Cox8a Apoe Cox7b Cox5a Maob Ppargc1b Gck Rxrb Sirt3 mt-Co1 Txnrd1 Asns Cox4i1 Cox4i2 Rrm2 Abcb4 Lmbrd1 Iqgap1 Slco1b2 Abcd4 Abcb11 Hpgd Lta4h Cyp2w1 Cyp2s1 Ahr Cyp2d22 Cyp3a16 Cyp3a13 Cyp3a57 Cyp2c65 Cyp2c55 Cyp2j6 Cyp2f2 Cyp2e1 Cyp1a1 Cyp2b10 Ahrr Cyp2c50 Cyp1a2 Cyp2a5 Hmox2 Dtymk Nudt13 Rrm1 Ak1 Nme3 Ak2 Glrx Ak5 Nme4 Ak7 Abcg2 Dctpp1 Dctd Cmpk1 Ak8 Nme6 Ctps2 Ctps1 Tymp Nt5c Nt5c1a Upb1 Agxt2 Upp1 Upp2 Dpys Dpyd Nt5m Slc9a1 Rdh11 Car9 Bckdhb Akr1c18 Bckdk Bckdha Dbt Cyp26b1 Dld Cyp26c1 Cyp26a1 Pld3 Aip REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 96%9759476 Regulation of Homotypic Cell-Cell Adhesion Sp1 Arhgap32 Psma4 Psma3 Psma6 Banp Psma5 Angptl4 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Kdm1a Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Zfp217 Psma7 Psmc6 Pip5k1c Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Ank3 Psmd3 Psmd2 Pomt1 Psmd1 Adrm1 Sem1 Pomt2 Ganab Mogs Tgif2 H2ac20 Tcf3 Zeb1 Klf9 Hdac1 Strap Foxj2 Foxp2 Myc Prkcsh Rpn2 Rpn1 Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 Sox10 H3c7 Twist2 Ezh2 H2ax Twist1 Snai2 Csnk2a2 Suz12 Hist1h2bp H2aj Jup H2bc9 H2bc7 H2bc8 H2bc3 Vcl Tmem258 H2ab2 Mycn Sec11c Sec11a H2bu2 Stt3a Src Canx Ctnnb1 Eps15 Cbll1 Ostc Rb1 Arid1a Tcf12 Ctnnd1 Cdh1 Dnm2 Kmt5a Mdm2 Zmym2 Mapk1 Mapk3 Hist2h2aa1 Furin Ctbp1 Mtbp Pcsk6 Ctbp2 Dad1 Rack1 Foxq1 Wt1 Zc3h12a Ddost Csnk2b Eed Tle1 Pcsk7 Cdh19 Pkm H2bc14 Foxa2 Zbtb33 Hdac2 Mphosph8 Tfap2a Mcrip1 H2bc21 Tnrc6c H2bc26 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Smarca4 Zeb2 Ctsb Ctss Spcs3 Spcs1 Hoxc8 Spcs2 Cdh8 Heyl Adam19 Adam33 Cdh24 Ctnna1 Snai1 Klf4 Prdm8 Ilf3 Foxf1 Bhlhe22 Cdh11 Sirt1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids Hadha Echs1 Hadhb Acsm3 Acadl Acads Hadh Acadvl Mecr Acadm SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209931 Serotonin and melatonin biosynthesis Tph1 Ddc Aanat Tph2 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 96%4724289 Defective ALG6 causes CDG-1c Alg6 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 96%3560801 Defective B3GAT3 causes JDSSDHD Sdc1 Gpc1 Ncan Bgn Cspg5 Gpc3 Cspg4 Gpc2 Agrn Dcn Hspg2 Bcan Gpc5 Sdc4 Vcan Sdc3 Gpc4 Sdc2 Gpc6 B3gat3 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Ptk6 Arap1 Akt1 Cbl Dok1 Ubc ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME%R-HSA-167242.4 Abortive elongation of HIV-1 transcript in the absence of Tat Nelfb Nelfe Supt5h Ctdp1 Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Polr2b Supt4h1a Polr2g Polr2h Nelfcd Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Nelfa Gtf2f1 DNA DAMAGE BYPASS%REACTOME%R-HSA-73893.3 DNA Damage Bypass Uba7 Rpa2 Rpa3 Polk Polh Pole Isg15 Sprtn Pclaf Ddb1 Usp43 Wdr48 Mad2l2 Ube2b Rev1 Usp1 Rev3l Cul4a Usp10 Rad18 Poli Cul4b Dtl Rchy1 Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Trim25 Rfc1 Rfc2 Pold4 Vcp Pold3 Rbx1 Ufd1 Pole3 Nploc4 Pole2 Ubc Pole4 Ube2l6 Rpa1 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 96%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) Runx3 Tbx21 Nfatc1 Il12rb2 Stat4 Ifng Tnf Tpst2 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693579 Homologous DNA Pairing and Strand Exchange Topbp1 Rpa2 Rad17 Rbbp8 Brca2 Brca1 Xrcc3 Rad51ap1 Xrcc2 Rpa3 Rad1 Atm Kat5 Exo1 Nbn Rfc5 Rfc3 Rfc4 Rfc2 Hus1 Atrip Brip1 Dna2 Rad51c Rad51d Blm Rad51b Chek1 Rad9a Bard1 Rad9b Top3a Wrn Mre11a Palb2 Sem1 Rad51 Rad50 Rpa1 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6791226 Major pathway of rRNA processing in the nucleolus and cytosol Xrn2 Nop58 Nop56 Rps14 Rpl4 Rps16 Las1l Rps18 Rrp1 Csnk1d Exosc9 Rps19 Ltv1 Exosc8 Mtrex Exosc5 Rpsa Rrp9 Dis3 Rpl37 Rpp38 Exosc4 Rpl39 Pwp2 Exosc7 Rps10 Bysl Exosc6 Fbl Rps11 Rpp30 Exosc1 Rpl7 Ftsj3 Exosc3 Imp3 Exosc2 Rpp21 Rpl32 Imp4 Rps9 Rpp25 Rps7 Rps5 Rpl24 Wdr75 Rpl26 Senp3 Rpl22 Isg20l2 Rpl23 Exosc10 Emg1 Eri1 Dhx37 Rps25 Rps26 Pno1 Pdcd11 Utp20 Rps21 Nop14 Pelp1 Utp25 Rpl39l Rcl1 Rps15a Tbl3 Nol12 Nol11 Rpp40 Wdr3 Bud23 Rps27l Dcaf13 Rplp2 Utp15 Rpl22l1 Rbm28 Rplp1 Riok3 Rpl13a Heatr1 Rpl18a Utp11 Nob1 Rpl17 Rpl18 Ddx52 Rpl19 Utp18 Rpl10l Wdr43 Rpl11 Wdr46 Noc4l Rps3 Riok1 Rps4x Riok2 Gnl3 Ddx49 Ddx47 Nip7 Rrp36 Nol9 Mphosph6 Rpp14 Nol6 Utp14a Mphosph10 Pes1 Bms1 C1d Krr1 Utp3 Utp4 Utp6 Bop1 Ebna1bp2 Wdr18 Tsr1 Ddx21 Wdr12 Csnk1e Rps27 SARS-COV-2-HOST INTERACTIONS%REACTOME%R-HSA-9705683.4 SARS-CoV-2-host interactions Mbl2 Gja1 Larp1 Sting1 Tyk2 Irf7 Ikbkb Nup133 Ifnar1 Traf3 Ikbkg Map3k7 Ywhae Ikbke Stat2 Nlrp3 B2m H2-Q10 Tjp1 Map1lc3b Becn1 Uvrag Irak1 Traf6 Ube2n Chuk Ube2v1 Tab3 Tab2 Tab1 Nup93 Nup50 Ywhah Nup35 Nup54 Pom121 Nup205 Nup188 Akt3 Tpr Akt2 Rae1 Akt1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Ywhaz Il17rc Il17ra Vps39 Rps14 Vps18 Vps11 Rps16 Vps16 Rps18 Rps19 Cav1 Rpsa Jak1 Sfn Rps10 Rps11 Hsp90aa1 Rps9 Rps7 Rps5 Vps41 Vps45 Rps25 Rps26 Tufm Rps21 Isg15 Rps15a Stat1 Tlr1 Rps27l Tlr2 Sftpd Hsp90ab1 Ifih1 Sike1 Rnf135 Trim25 Mavs Rigi Rps3 Rps4x Vps33a Vps33b Crb3 Patj Pals1 Tomm70 Ifnb1 Ywhab Ywhag Pdpk1 Nup37 Nup160 Nup43 Pik3c3 Ranbp2 Ptpn6 Nlrp12 Ptpn11 H2-M5 H2-M3 Ripk2 Tbk1 Nup107 G3bp1 G3bp2 Irf3 Pik3r4 Rps27 H2-Q1 Gemin7 Gemin4 Nod2 Gemin5 Nod1 Cnbp Snrpb Smn1 Sar1b Snrpd2 Sec23a Tkfc Snrpd1 Nup85 Irak2 Snrpd3 Gemin2 Ddx20 Il17f Tlr8 Il17a Tlr7 Sec24d Sec24c Crebbp Sec24b Sec13 Sec24a AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Cenpo Cenpn Cenpm Mis12 Plk1 Nup133 Cenpl Zwilch Cenpk Cenpi Cenph Cenpf Cenpe Clasp1 Clasp2 Pafah1b1 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Kif2b Kif2c Dync1li2 Pmf1 Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Ppp2r1b Ppp2r1a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Xpo1 Nuf2 Nup85 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport Prkaca Prkar2b Aqp12 Gng10 Aqp11 Gng3 Rab11a Gng2 Rab11fip2 Aqp9 Prkar1a Aqp7 Gng4 Gng7 Gng8 Prkacb Avpr2 Prkar2a Avp Gngt1 Gngt2 Adcy3 Aqp6 Adcy4 Aqp5 Adcy1 Aqp8 Aqp4 Adcy2 Aqp3 Adcy7 Aqp2 Adcy8 Adcy5 Adcy6 Adcy9 Mip Gnb2 Myo5b Aqp1 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Prkar1b Gng13 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 96%5173214 O-glycosylation of TSR domain-containing proteins Adamts1 Adamts5 Adamts4 Adamts3 Adamts2 Adamts8 Adamts7 Adamts6 Pofut2 Sema5a Sema5b Thsd1 Thbs2 Thsd4 Adamts13 Adamts14 Adamts15 Adamts16 Cfp Adamts18 Adamts19 Spon2 Spon1 Adamts10 Sbspon Adamts12 B3glct Thsd7a Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Adamts20 Thsd7b Thbs1 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602415 UNC93B1 deficiency - HSE Unc93b1 Tlr3 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli Prkaca Cacnb1 Cacnb2 Gja1 Pecam1 Pkn2 Itgb3 Flt4 Ikbkb Tln1 Vcl Mmp14 Capn2 Ikbkg Stat1 Rictor Ikbke Nfkb1 Spp1 Capns1 Capns2 Prkacb Rela P2ry2 Ctnnb1 Adcy3 Adcy4 Gna11 Adcy1 Adcy2 Adcy7 Pik3cb Adm Adcy8 Pik3cd Adcy5 Adcy6 Kdr Pik3ca Adcy9 Itgav Ppp2r2a Ptk2 Anxa2 Gnaq Prr5 Nfkbia Pdpk1 Calcrl Prkar1b Chuk Cdh5 Ppp2ca Prkar2b Mlst8 P2rx7 Gng10 Itga5 Mtor Fyn Nos3 Gng3 Akt1 Gng2 Hspg2 Prkar1a Gng4 Abl1 Gng7 Mapkap1 Gng8 Ppp2r1b Ppp2r1a Prkar2a Gngt1 Gngt2 Panx1 Cacng7 Itgb1 Cacna1h Ptpn1 Ramp2 Gnb2 Gnb1 Cacna2d1 Gnb4 Trpv4 Gnb3 Gnb5 Gng11 Pik3r2 Gng12 Yap1 Cacnb3 Gng13 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371598 Defective BTD causes biotidinase deficiency Btd INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes Pycard Nlrp3 Nlrp1a Pstpip1 Rela Sugt1 P2rx7 Aim2 Nlrc4 Casp1 App Panx1 Nfkb2 Bcl2 Bcl2l1 Mefv Txnip Nfkb1 Txn Hmox1 Hsp90ab1 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription Dlgap5 Pbx1 Hey2 Plxnd1 Hey1 Ptcra Notch3 Mamld1 Notch1 Kat2b Maml1 Maml2 Kat2a Heyl Hes5 Stat1 Rbpj Crebbp Hes1 Ep300 Wwc1 Fabp7 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 96%5666185 RHO GTPases Activate Rhotekin and Rhophilins Rhpn1 Rhpn2 Ropn1 Lin7b Rhob Rhoc Rhoa Rtkn FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Nr3c1 G6pc1 Smad2 Smad3 Smad4 Foxo4 Hdac2 Hdac1 Foxo1 Abca6 Sod2 Trim63 Foxo3 Npy Cat Sin3a Srebf1 Pomc Agrp Gck Igfbp1 Fbxo32 Plxna4 Ppargc1a Atxn3 Retn Ins2 Pck1 Sirt3 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 96%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs Gata3 Gata1 Gata2 H2bc9 H2bc7 Psma4 H2bc8 Psma3 H2bc3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 H2ab2 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 H2bu2 Psmb1 Psmb3 Psmb2 Itch Tal1 Psma7 Psmc6 Lmo2 Psmc5 Lmo1 Psmc2 Tcf12 Psmc1 Cbfb Psmc4 Psmc3 Ubc Psmd7 Psmd6 Hist2h2aa1 Psmd8 Psmd3 Psmd2 Mnat1 Psmd1 Adrm1 Sem1 Trp73 Ccnh Cdk7 H2bc14 H2ac20 Tcf3 Ldb1 H2bc21 H2bc26 Abl1 H2ac12 H2ac11 Spi1 H2ac15 H3c7 H2ax Myb Hist1h2bp H2aj Yap1 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.3 AXIN missense mutants destabilize the destruction complex Ppp2cb Ppp2ca Gsk3b Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Hey2 Hey1 Mib2 Ncor2 Skp1 Mamld1 Notch1 Rbx1 Ubc Kat2b Kat2a Cul1 Hdac2 Hdac1 Hdac5 Hdac4 Myc Hdac7 Hdac6 Hdac9 Hdac8 Ncor1 Dll4 Hes1 Jag2 Jag1 Adam10 Ep300 Cdk8 Neurl1b Tbl1x Adam17 Neurl1a Dll1 Mib1 Hdac3 Tbl1xr1 Psen1 Psen2 Ncstn Maml1 Aph1b Maml2 Heyl Hdac11 Hdac10 Hes5 Rbpj Ccnc Crebbp APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 96%179409 APC-Cdc20 mediated degradation of Nek2A Anapc15 Mad2l1 Bub1b Ubc Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Nek2 Ube2e1 Bub3 Cdc23 Cdc20 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events Rbp4 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid Dhrs4 Rxrg Dlat Rxra Rara Adh4 Dhrs3 Adh1 Fabp5 Aldh1a2 Rdh11 Aldh1a3 Rarb Rdh10 Akr1c18 Aldh8a1 Ppard Rdh13 Rdh14 Cyp26b1 Dld Cyp26c1 Rdh16f2 Cyp26a1 Rdh5 Aldh1a1 Crabp1 Dhrs9 Sdr16c5 Pdhx Rarg Pdha1 Pdha2 Pdk4 Rxrb Pdk3 Crabp2 Pdk2 Pdk1 Pdhb WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis Far2 Dhrs7b Far1 Awat1 Agps Gnpat Awat2 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-HSA-2173788.3 Downregulation of TGF-beta receptor signaling Ppp1cc Pmepa1 Smad2 Uchl5 Smad3 Tgfb1 Usp15 Xpo1 Bambi Mtmr4 Strap Stub1 Smad7 Ubc Nedd4l Ppp1ca Tgfbr1 Ppp1cb Smurf2 Tgfbr2 Smurf1 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9932444 ATP-dependent chromatin remodelers Actl6a Actl6b Smarce1 Rbm17 Ddx46 Ddx42 Pbrm1 Actb Chd1 Adnp2 Adnp Mta1 Mta3 Nr2c2 Dkk2 Arid2 Cbx3 Chd8 Phf6 Zfp592 Tcf19 Cdk2ap1 Cdk2ap2 Nr2f2 Mbd2 Zmynd8 Ikzf3 Igf2 Znf687 Ikzf2 H2ac20 Ikzf1 Tcf3 Pwwp2a Chd5 Mbd3l1 Zfp827 Hdac1 Pwwp2b Ube2i Bicral Bicra Brd9 Bcl11a Chd3 Chd4 H2ac12 H2ac11 H2ac15 H3c7 Phf5a H2ax Axin2 Mta2 Hist1h2bp H2aj Puf60 Chd6 Nqo1 Smndc1 H2bc9 Myog H2bc7 Myod1 H2bc8 H2bc3 Cdc73 Rtf1 Gatad2a Tcf4 Gatad2b Leo1 Skic8 H2ab2 Mbd3 H2bu2 Ctr9 Cbx1 Paf1 Ctnnb1 Arid1a Arid1b Tcf12 Brd7 U2surp Snrpb2 Snrpa1 Hist2h2aa1 Chd2 Wdr5 Nkd2 Fam124b Sf3a1 Chd7 Sf3a2 Ss18 Sf3a3 Dpf1 Dpf2 G6pc1 Sf3b1 Sf3b2 Dpf3 Sf3b3 Sf3b4 Ss18l1 Sf3b5 H2bc14 Sf3b6 Bcl7a Bcl7b Bcl7c Hdac2 Smarcb1 Snrpn H2bc21 H2bc26 Cherp Rbbp4 Ctcf Rbbp7 Smarca2 Smarca4 Ep300 Smarcd1 Smarcd2 Bcl11b Snrpb Phf10 Smarcc2 Smarcc1 Snrpd2 Snrpd1 Dhx15 Smarcd3 Fbp1 Snrpd3 Mafk Supt16 Nfe2l2 Ssrp1 Crebbp Chd9 Pck1 ACETYLATION%REACTOME DATABASE ID RELEASE 96%156582 Acetylation Nat1 Nat2 NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717301 NVP-TAE684-resistant ALK mutants Alk PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling Nrg3 Gab1 Nrg1 Egfr Pik3ca Erbb2 Egf Ereg Hbegf Btc Pik3r1 Nrg2 Nrg4 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 96%1237044 Erythrocytes take up carbon dioxide and release oxygen Ca2 Hbbt1 Ca4 Cyb5rl Rhag Slc4a1 Aqp1 Cyb5r4 Cyb5r2 Ca1 Cyb5r1 Hba-a1 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9033807 ABO blood group biosynthesis Fut2 Fut1 Abo DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance Atrx Daxx INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA Psip1 Hmga1 Banf1 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 96%4641263 Regulation of FZD by ubiquitination Lrp6 Lrp5 Lgr4 Lgr5 Fzd5 Lgr6 Fzd4 Rspo3 Fzd6 Usp8 Fzd8 Ubc Rnf43 Znrf3 Wnt3a Rspo1 Rspo2 Rspo4 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 96%8986944 Transcriptional Regulation by MECP2 Trpc3 Prkaca Gad1 Gad2 Ncor2 Htt Fkbp5 Sgk1 Hipk2 Gps2 Met Irak1 Gprin1 Oprm1 Crh Pvalb Gria2 Bdnf Pparg Hdac2 Hdac1 Grin2b Foxg1 Slc2a3 Tnrc6c Ncor1 Mobp Tnrc6a Tnrc6b Grin2a Camk4 Tbl1x Mov10 Dll1 Sin3a Ago4 Pten Ago3 Hdac3 Ago2 Sst Ago1 Lbr Sox2 Tbl1xr1 Camk2g Gamt Camk2d Camk2b Rbfox1 Dgcr8 Ptpn4 Camk2a Ptpn1 Aurkb Oprk1 Mef2c TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME DATABASE ID RELEASE 96%5250989 Toxicity of botulinum toxin type G (botG) Syt1 Vamp1 Vamp2 VITAMINS%REACTOME DATABASE ID RELEASE 96%211916 Vitamins Cyp27b1 Cyp26b1 Cyp26c1 Cyp26a1 Cyp24a1 Cyp2r1 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351200 Interconversion of polyamines Sat1 Paox DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 96%9766229 Degradation of CDH1 Jup Psma4 Psma3 Psma6 Psma5 Banp Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Src Ctnnb1 Eps15 Cbll1 Psma7 Psmc6 Psmc5 Psmc2 Ctnnd1 Psmc1 Cdh1 Psmc4 Dnm2 Psmc3 Mdm2 Ctsb Ubc Ctss Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Ctnna1 Mtbp Psmd1 Rack1 Adrm1 Sem1 UREA CYCLE%REACTOME DATABASE ID RELEASE 96%70635 Urea cycle Arg1 Nags Trp53 Slc25a2 Asl Cps1 Nmral1 Ass1 Sirt5 Otc Arg2 Slc25a15 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2122948.5 Activated NOTCH1 Transmits Signal to the Nucleus Arrb1 Dtx1 Dtx2 Dlk1 Dner Mib2 Dtx4 Cntn1 Dll4 Jag2 Jag1 Adam10 Neurl1b Adam17 Neurl1a Dll1 Mib1 Itch Notch1 Ubc Psen1 Psen2 Ncstn Aph1b Numb Arrb2 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-HSA-2299718.4 Condensation of Prophase Chromosomes Smc4 Smc2 H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 H2bc3 Plk1 H2bc21 H2bc26 H2ab2 H3c8 Cdk1 H2bu2 H2ac12 H2ac11 Ncaph2 Ncapd3 Ncapg2 H2ac15 H3c7 Rb1 H2ax Mcph1 Kmt5a Hist1h2bp Hist2h2aa1 H2aj RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration Akt3 Itgbl1 Akt2 Akt1 Mmp13 Itga5 Cbfb SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies Hmgcl Bdh2 Bdh1 Hmgcll1 Hmgcs2 Acat1 Aacs RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape Gtf2h3 Taf4 Taf3 Gtf2h5 Taf2 Ercc2 Taf1 Ccnh Ercc3 Cdk7 Taf15 Taf11 Taf13 Taf12 Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Polr2c Taf9 Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Taf8 Gtf2h2 Gtf2h1 Taf7 Gtf2f2 Taf6 Gtf2h4 Gtf2f1 Taf5 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Kpna1 Aaas Nup214 Banf1 Nup210 Nup155 Nup153 Psip1 Hmga1 Nup85 Nup37 Sec13 Nup160 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 96%75067 Processing of Capped Intronless Pre-mRNA Nudt21 Cpsf7 Cpsf1 Cstf2 Cpsf2 Cstf3 Cpsf3 Pabpn1 Snrpb Cstf2t Wdr33 Fip1l1 Snrpd3 Cpsf4 Ncbp2 Zfp473 Ncbp1 Slbp Sympk Lsm10 Cstf1 Lsm11 Papola Clp1 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Hdac2 Hdac1 H2bc3 H2bc21 Gatad2a H2bc26 Gatad2b Rbbp4 Ehmt2 Rbbp7 H2ab2 Mbd3 Chd3 H2bu2 Chd4 H2ac12 H2ac11 Mta1 Ercc6 H2ac15 Mta3 H3c7 H2ax Ttf1 Mta2 Hist1h2bp Hist2h2aa1 H2aj Cbx3 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%442720 CREB1 phosphorylation through the activation of Adenylate Cyclase Prkar2a Prkaca Prkar2b Prkar1a Adcy1 Prkacb Adcy8 Prkar1b Prkx CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 96%2025928 Calcineurin activates NFAT Fkbp1a Nfatc1 Nfatc3 Ppia Nfatc2 Ppp3r1 Ppp3ca Ppp3cb MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) Cat Nrf1 Lonp1 Esr1 Htra2 Hspa9 Dnaja1 Hsf1 Atf5 Sod2 Akt1 Hspd1 Foxo3 Hspa1a Sirt3 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 96%69416 Dimerization of procaspase-8 Tradd Traf2 Fas Fasl Casp8 Tnfsf10 Ripk1 Tnfrsf10b Fadd ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 96%8847993 ERBB2 Activates PTK6 Signaling Erbb2 Nrg3 Egf Ptk6 Ereg Hbegf Btc Nrg1 Nrg2 Nrg4 Egfr INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 96%877300 Interferon gamma signaling Jak2 Trim62 Ciita Oas3 Irf8 Trim21 Irf6 Irf9 Trim26 Trim38 Irf7 Trim35 Trim31 Raf1 Ifngr2 Ifngr1 Socs1 Cd44 Irf2 Trim25 B2m H2-Q10 Irf5 Oas2 Gbp2 Gbp3 Fcgr1 Gbp9 Mapk1 Mapk3 Socs3 Ybx1 Irf1 Ifng Ptpn6 H2-Eb1 Irf4 Smad7 Ptpn11 H2-M5 Ncam1 Ifi30 H2-M3 Gbp5 Gbp7 Pias1 Irf3 Trim17 Trim14 Trim10 Icam1 Oas1g H2-Q1 Prkcd Ptafr Mt2 Trim6 Trim8 Camk2g Trim3 Trim2 Camk2d Camk2b Trim12c Camk2a Ptpn1 Jak1 Mid1 Oasl1 Trim68 Pml Vcam1 Trim46 Trim45 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%8856688 Golgi-to-ER retrograde transport Arfgap1 Kdelr2 Capzb Capza1 Capza2 Actr1a Copz2 Copz1 Dctn2 Arf5 Dctn3 Rab18 Galnt2 Cenpe Sec22b Rab1a Rab1b Tmed9 Tmed3 Copg1 Copg2 Kif3a Kif3b Kif3c Copb2 Agpat3 Pla2g6 Kif4 Galnt1 Copb1 Arf4 Pafah1b3 Pafah1b2 Actr10 Dctn5 Dctn6 Dctn1 Dctn4 Kif26a Capza3 Bicd2 Kif11 Bicd1 Kif15 Kif22 Kif23 Kif20a Kdelr3 Klc1 Klc4 Klc3 Klc2 Kifap3 Gbf1 Kif18b Use1 Kif26b Kifc2 Kif12 Nsf Kif21a Kif1c Kif21b Kif13b Kif1a Kif1b Bnip1 Kif6 Kif9 Stx18 Kif27 Rint1 Kif16b Kif20b Kif19a Surf4 Arf1 Arfgap2 Arcn1 Kdelr1 Pafah1b1 Kif5b Zw10 Napa Napb Napg Rab6b Kif2a Rab6a Kif2b Kif2c Dync1li2 Dync1li1 Dynll1 Dynll2 Racgap1 Copa Pla2g4a Arfgap3 Kif18a Dync1h1 Arf3 Cope Dync1i2 Dync1i1 Rab3gap1 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 96%9615933 Postmitotic nuclear pore complex (NPC) reformation Nup43 Tnpo1 Ran Nup93 Nup85 Nup35 Rcc1 Nup54 Pom121 Nup205 Ube2i Nup133 Nup188 Ahctf1 Nup107 Ndc1 Nup62 Kpnb1 Nup37 Sec13 Nup155 Nup160 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9635465 Suppression of apoptosis Gsk3a Sfpq Mapk1 Mapk3 Ctsg Rnf213 Trim27 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196780 Biotin transport and metabolism Acacb Acaca Btd Mccc1 Pcx Pcca Mccc2 Pccb Slc5a6 Hlcs Pdzd11 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters Abcb6 Abcb10 Abcb8 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 96%5545619 XAV939 stabilizes AXIN Tnks2 Tnks SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 96%9717189 Sensory perception of taste Gnat3 Tas2r40 Tas2r41 Itpr3 Scn3a Plcb2 Scnn1a Trpm4 Scnn1b Kcnj2 Scnn1g Trpm5 Grm1 Scn4b Calhm1 Tas2r39 Tas2r119 Tas2r38 Grm4 Tas1r2 Tas1r1 Tas2r120 Tas1r3 Tas2r16 Tas2r13 Tas2r137 Scn9a Tas2r136 Tas2r140 Otop1 Tas2r4 Scn1b Tas2r107 Tas2r7 Gnb1 Gnb3 Scn2a Scn2b Gng13 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 96%9735869 SARS-CoV-1 modulates host translation machinery Rps5 Hnrnpa1 Rps3 Rps4x Rps25 Rps26 Rps21 Rps14 Rps16 Rps15a Rps18 Rps19 Rpsa Rps10 Rps27l Rps27 Rps11 Rps9 Rps7 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication Hsp90aa1 Hsp90ab1 COMPLEX IV ASSEMBLY%REACTOME%R-HSA-9864848.2 Complex IV assembly Cox14 Cox8a Cox16 Cox18 Cox6b1 Tmem177 Cox6b2 Coxfa4 Cox7b Smim20 Cox15 Cmc1 mt-Co1 Tmem223 mt-Co2 Sco1 mt-Co3 Coq10a Cox4i1 Coq10b Rab5if Cox4i2 Cox19 Cox17 Surf1 Higd2a Cox5a Cox6a1 Cox6a2 Timm21 Cox7a1 Cox7a2 Cox20 Taco1 Coa3 Cox7a2l Cox11 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Cdkn2a C1qbp PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 96%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Rorc Per1 Clock Per3 Bmal1 Rora Tfeb Crtc1 Npas2 Sik1 Nr1d1 Rbm4 Dbp Cipc Crebbp Bhlhe40 Cry1 Cry2 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 96%166786 Creation of C4 and C2 activators Colec11 Mbl2 C1qc Fcn2 Crp C1qb C1qa C1rb Colec10 C1s2 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis Fut2 St3gal6 Fut1 Fut4 B3galt2 Fut7 B3galt1 Fut9 St3gal4 Rhd St6galnac6 B4galnt2 Abo B3galt5 B3galt4 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence Mcm5 Mcm2 Lig1 Brca1 Tert IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions Cntf Cntfr Jak2 Clcf1 Osm Lifr Ctf1 Crlf1 Tyk2 Lif Jak1 Il31ra Il11 Il6st Osmr SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways Col4a1 Col4a2 Col9a2 Col9a3 Col6a6 Il3ra Il2rb Col6a3 Col4a5 Csf2rb2 Csf2ra Col9a1 Il5 Il5ra Angptl3 Ap2m1 Nr1h3 Prkacb Abcg1 Mylip Ap2a2 Ap2a1 Ap2b1 Ap2s1 Apoc1 Apoc2 Abca1 Apoc4 P4hb Rag2 Rag1 Gdnf Id4 Gfra1 B4galt1 Srms Acvr1c Acvr1b Acvr2b Cer1 Sall4 Ppp1r12b Ppp1r12a Ppp1r14a Ptprz1 Gpc5 Aldh1a1 Abcd3 Egr2 Lep Sox17 Mmp2 St3gal6 Mfng Rfng Pofut1 Flt4 Poglut1 Srgap1 Mdk Srgap2 Mag Lingo1 Srgap3 Omg Arhgap39 Rtn4 Nab1 Nab2 Trib1 Arc Tph1 Ikbke Id2 Optn Id3 Adh4 Fosl1 Egr3 Egr4 Adh1 Dnal4 Lyl1 Ascl1 Rrad Cdk5r2 F3 Flt3l Vgf Map2k5 Mta1 Mta3 Abcg8 Abcg5 Socs6 Gsk3a Plcb3 Plcb2 Plcb1 Pde6g Prkca Gnao1 Nlk Gnat2 Prkg2 Pde6a Pde6b Prkg1 Alk Prkar1a Strn Spry2 Mknk1 Hgfac Pdhx Pdha1 Pdha2 Pdk4 Pdk3 Pdk2 Pdk1 Pdhb Dlat Trat1 Pdgfrb Pik3ap1 Ntrk3 Ptpru Cma1 Grap Sh2b2 Sh2b3 Fer Tec Fes Ranbp10 Crhr2 Kif5b Csnk1e Csnk1a1 Pard6a Inhbb Pard3 Cgn F11r Rhoa Prkcz Arhgef18 Opn1sw Rps6ka5 Arl13b Pde6d Lman1 Mcf2l Rab7 Rhog Arhgdib Arhgdia Garre1 Arhgef16 Shmt2 Arhgdig Arfgap3 Erbin Emd Lemd3 Iqgap2 Diaph3 Cdc42ep1 Depdc1b Vrk2 Vamp3 Epha2 Dock5 Arhgef26 Itsn1 Arhgap5 Itgb1 Dock4 Arhgap1 Kalrn Arhgap21 Letm1 Vangl1 Mcam Ophn1 Stbd1 Ndufa5 Pld1 Dock1 Dock2 Vapb Elmo2 Stx5 Arhgap32 Ykt6 Pak4 Prex1 Arhgap35 Trio Mcf2 Esyt1 Plekhg3 Mtmr1 Mpp7 Ktn1 Ankle2 Cyfip1 Pip5k1b Tmpo Pip5k1a Plin3 Epor Plin1 Mgll Ppp1ca Ppp1cb Grem2 Bmp10 Fabp5 Acvrl1 Fabp6 Fabp7 Amhr2 Amh Zfyve16 Nog Gdf2 Bmpr1a Bmpr1b Bmpr2 Smad9 Smad5 Fstl1 Ptprs Ptprf Itgav Ptk2 Cxcr4 Pfn1 Pfn2 Cxcl12 Abl2 Nrp1 Flrt3 Nck2 Nck1 Evl Rnd3 Ckb Sema4f Sos2 Nisch Kctd13 Tnfaip1 Pak6 Ckap4 Cdc14a Myo9b Pak5 Prkar2a Il1rl1 Rhou Il33 Ptk2b Hecw1 Klhl12 Wdr91 Osbpl11 Wdr81 Arhgap4 Arap1 Elk1 Arhgap9 Ereg Arhgap8 Fam91a1 Hbegf Btc Gmip Baiap2l2 Epgn Golga3 Uhmk1 Vma22 Ngfr Def6 Sqstm1 Fgd5 Gopc Lrrc1 Ralgapa1 Wdr11 Arfgap2 Akap12 Tex2 Mospd2 Cltb Arhgap12 Arhgap19 Arhgap18 Efhd2 Arhgap22 Arhgap20 Arhgap25 Arhgap24 Arhgap23 Arhgap29 Dnm2 Arhgap28 Whamm Arhgap33 Arhgap31 Sh3pxd2a Arhgap30 Dock11 Plekhg6 Plekhg4 Plekhg1 Mtr Ralbp1 Arhgap40 Arhgap44 Arhgap45 Filip1 Hint2 Adra2a Adra2c Ankfy1 Adra2b Faf2 Klb Rhoh Fgf16 Rhof Fgf15 Rhod Irs1 Rhov Fgf18 Diaph2 Fam13b Irs2 Fgf2 Shkbp1 Pik3c3 Arhgap11a Fgf1 Emc3 Fgf4 Farp1 Fgf10 Kctd3 Fgf3 Cdc42ep2 Fgf6 Cdc42ep5 Fgf7 Cdc42ep3 Fgf9 Cdc42ep4 Fgf20 Syde2 Dnmbp Gab2 Fgf23 Nsfl1c Fgfr4 Rhpn1 Fgf22 Ccdc187 Acbd5 Pde3b Tlr9 Basp1 Pik3r4 Maco1 Ddrgk1 Spata13 Peak1 Gfod1 Rnd2 Dock6 Itga3 Als2 Bltp3b Armcx3 Itga2 Add3 Tor1aip1 Fmnl2 Fmnl1 Cdc42se2 Tmem87a Il6ra Sh3bp1 Zfp512b Nedd4 Prag1 Gpnmb Lrrk2 Sh3rf1 Mkrn1 Rbck1 Socs1 Ube2m Rnf41 Lrrc41 Dusp2 Dusp5 Paqr3 Dusp1 Dusp10 Dusp9 Dusp8 Prickle1 Cul5 Ptpra Artn Gfra2 Gfra3 Gfra4 Dok1 Pspn Vhl Nrtn Hgf Fgfbp3 Fgfbp1 Ctbp1 Ctbp2 Ncf1 Ncf2 Ncf4 Brk1 Ocrl Swap70 Amigo2 Noxa1 Rac3 Git1 Baiap2 Arhgap15 Arhgap17 Nckap1l Fermt2 Bcr Arhgap6 Arap3 Arap2 Baiap2l1 Arhgap26 Syde1 Abr Nckap1 Slitrk5 Slitrk3 Nhs Git2 Wasf2 Wasf1 Noxo1 Dock10 Racgap1 Taok3 Snap23 Cyba Abi2 Abi1 Cybb Nox3 Arhgap42 Nox1 C1qbp Dnmt1 Pdgfra Psen1 Psen2 Ncstn Aph1b Heyl Hes5 Elmo1 Adora2b C3ar1 Prkx Plcg2 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Btk Dvl1 Dvl2 Dvl3 Arpc3 Arpc2 Cyfip2 Arpc5 Arpc4 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Gnaz Adcy9 Syk Gnai2 Gnai1 Gnai3 Nckipsd Prkar1b Was Wasf3 Gnat3 Prkar2b Cysltr2 Cysltr1 Wasl Rnf146 Tnks2 Tnks Trim27 Otud3 Wwp2 Usp13 Frk Il2rg Plcb4 Camkk1 Camkk2 Prkcg Arhgef9 Gnal Gabrg2 Gabrg3 Lin7b Rasgrf1 Rasgrf2 Gabbr1 Gabbr2 Gabra1 Nrg1 Gabrq Gabrb1 Gabrb3 Gabrb2 Prkci Ripk2 Myd88 Rho Gnat1 Vrk3 Saa3 S100b Dusp3 Dusp4 Irak4 Dusp7 Dusp6 Mef2a Trak1 Cep97 Rpgrip1l Fstl3 Ift88 Sstr3 Notum Sox3 Trrap Sox7 Sox6 Pygo2 Ift140 Sox4 Pygo1 Dkk1 Dkk2 Dkk4 Rnf43 Sox13 Kremen2 Kremen1 Bcl9l Bcl9 Kif3a Cby1 Znrf3 Csnk1g2 Sfrp2 Sfrp1 Rspo1 Rspo2 Nphp4 Rspo4 Chd8 Lrp6 Lrp5 Wif1 Mks1 Ccdc88c Ryk Ctnnbip1 Lgr4 Ift52 Sost Lgr5 Lgr6 Frat2 Frat1 Ttc21b Shb Sh2d2a Nos3 Ift57 Mchr1 Ift122 Ofd1 Klc1 Klc4 Klc3 Klc2 Tle5 Wdr35 Dync2h1 Ccp110 Ift172 Wdr19 Rab9 Gpr15 Gpr25 Gpr27 Gpr20 Gpr45 Gpr84 Gpr83 Pde10a Pde11a Gpr176 Rab9b Gpr150 Pde7b Pde7a Rgs8 Pde8a Pde8b Pcp2 Grk6 Gpsm3 Gpsm2 Gpsm1 Pde3a Ppp1r1b Pde2a Pde4a Rgs20 Rgs22 Rgs14 Pde4c Pde4d Rgs10 Rab6a Rgs12 Rhobtb3 Scai Ropn1 Nf2 Prc1 Zdhhc7 Flna Ugt1a2 Crabp2 Zdhhc21 Ppid Cav2 Mmp7 Stat5a Stat5b Grb2 Ebag9 Cxxc5 Tle3 Kdm1a Greb1 Ddx5 Ctsd Kdm4b Kank1 Pou2f1 Fkbp4 Chd1 Tff3 Zfp217 Foxa1 Ncoa3 Usf1 Usf2 Nr5a2 Spta1 Nrp2 Sptb Numb Dnm1 Sptan1 Dnm3 Ranbp9 Ncam1 Sptbn1 Sptbn2 Cntn1 Sptbn4 Elf3 Sirt6 Flrt1 Flrt2 Flt1 Lypla1 Tax1bp1 Clip3 Smpd2 Smpd3 Nsmaf Sppl2b Otulin Sppl2a Abhd17b Abhd17a Abhd17c Rce1 Ruvbl1 Pgf Fst Drap1 Foxh1 Adam12 Ier3 Phlpp1 Phlpp2 Rps6kb2 Atn1 Maf1 Il17rd Igf2bp1 Wdr83 Rgl3 Rgl1 Rgl2 Pea15 Shoc2 Mras Septin7 Rapgef2 Mapk6 Mapk4 Cdc14b Rasgef1a Angpt1 Etv4 Tek Pla2g4a Grk2 Pde1b Pde1c Prkcd Pde1a Matk Wnt5b Ror1 Ror2 Sufu Insr Grb10 Stat6 Psma4 Ikbkb Psma3 Psma6 Psma5 Psma2 Psma1 Ikbkg Map3k7 Scfd1 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rela Prkcb Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Cul1 Chuk Nr3c1 Nr1h2 Esr1 Pparg Ar Rxra Hdac4 Daglb Rara Dgka Dgkb Pgr Abhd6 Dgke Abhd12 Kat5 Dgkg Dgkh Dgki Dgkk Dgkq Prkch Dgkz Dagla Prkce Fgfrl1 Rxfp3 Rln3 Rxfp2 Rxfp1 Rln1 Insl3 Rxfp4 Insl5 Rhob Anln Arhgef17 Slk Arhgef11 Arhgef10 Cavin1 Iqgap3 Diaph1 Chek1 Daam1 Akap13 Cit Arhgef25 Arhgef28 Sowahc Stom Pkn3 Arhgef3 Arhgef2 Arhgef1 Pcdh7 Ect2 Myo9a Rtkn Actc1 Jup Rhpn2 Stk10 Net1 Arhgef10l Stard8 Dlc1 Stard13 Pkn2 Pkn1 Tiam2 Rhoc Plxnb1 Arhgef15 Arhgef19 Plk1 Ngef Adra1b Adra1a Zranb1 Adra1d Gna12 Rhot1 Arhgef7 Arhgef6 Tbxa2r Arhgef4 Gna13 Cdk1 Fgd2 Fgd1 Ube2d1 Fgd4 Arhgef37 Fgd3 Arhgef39 Arhgef38 Stam2 Arhgef40 Plekhg5 Sh3gl3 Plekhg2 Src Sh3kbp1 Stam Ctnnb1 Eps15 Cbl Hgs Ctnnd1 Rab4b Cdh1 Sh3gl1 Sh3gl2 Kdr Met Shc3 Ptk6 Shc2 Shc1 Mapk1 Braf Mapk3 Crkl Ywhab Mapk12 Gpr143 Rap1a Mapkapk3 Htr4 Chrm1 Mapk13 Hrh1 Mapkapk2 Chrm3 Mapk14 Rala Htr6 Ralb Chrm2 Htr7 Frs2 Ngf Chrm5 Hrh4 Kidins220 Ralgds Chrm4 Hrh2 Map2k2 Hrh3 Rit1 Htr2a Rit2 Nras Htr2c Ntrk1 Htr2b Drd1 Map2k1 Adrb2 Rapgef1 Drd2 Sos1 Adrb1 Crk Drd3 Hras Drd4 Mapk11 Drd5 Adrb3 Taar8b Htr1d Taar6 Htr1f Taar9 Taar2 Taar5 Ncor1 Atf2 Htr1b Htr1a Taar1 Carm1 Htr5a Nrip1 Ep300 Tbl1x Mef2d Ppp5c Hdac3 Kdm4a Ncoa2 Ncoa1 Xpo1 Tbl1xr1 Med1 Pgrmc2 Ctnna1 Snai1 Crebbp Mef2c Wwc1 Tacc3 Dlgap5 Fkbp1a Pbx1 Plxnd1 Nfatc1 Ptcra Rasgrp3 Rcor1 Rasgrp1 Jak3 Ppp3r1 Ppp3ca Ppp3cb Tyk2 App Jun Cdk5r1 Bcl2l11 Ywhae S1pr1 Cdk5 Fasl Fnta Fntb Cdc25c Foxo3 Lmnb1 Notch1 Rbx1 Ucn Sct Snx3 Ihh Adm Adcyap1 Ramp1 Shh Wnt5a Wnt9a Iapp Wnt9b Ucn3 Fzd10 Wnt10a Crhr1 Wnt10b Crhbp Gipr Gip Calcrl Smo Glp1r Crh Pth1r Wnt8b Wnt8a Wnt16 Wnt11 Calcr Ghrhr Adgre5 Gng10 Pth Dhh Adgre1 Gcgr Pth2 Glp2r Strap Wnt6 Vipr2 Calca Vipr1 Gng3 Gng2 Ptch2 Ptch1 Gng4 Wnt7b Hspb1 Gng7 Ghrh Wnt3a Gng8 Pth2r Wnt7a Wnt2 Casp9 Pthlh Bad Wnt1 Wnt4 Wnt3 Fzd1 Gngt1 Cdc42bpa Gngt2 Cdc42bpb Fzd3 Fzd2 Rhoj Slc4a7 Fzd5 Fzd4 Fnbp1 Dock8 Fzd7 Fnbp1l Fzd6 Fzd9 Cpne8 Fzd8 Scrib Gcg Fmnl3 Nipsnap2 Adcyap1r1 Wnt2b Spint1 Ramp3 Hpn Ramp2 Mst1 Mst1r Gnb2 Adm2 Spint2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Vip Gng12 Gng13 Rasal1 Rasal2 Rasal3 Syngap1 Kbtbd7 Spred1 Spred3 Spred2 Rasa2 Rasa1 Rasa4 Rasa3 Nf1 Dab2ip Cul3 Cdc73 Leo1 Ccne1 Ptn Alkal1 Tfdp2 Tfdp1 Ccnd3 Ccnd1 Cdk4 Cdk2 E2f1 Gpr161 Axl E2f3 Gli1 Intu Cdkn1a Tulp3 Cdkn1b Adcy10 Fuz Flt3 Clasp1 Clasp2 Pafah1b1 Smc3 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Rad21 Kif2b Kif2c Dync1li2 Pmf1 Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Stag2 Stag1 Ppp2r1b Ppp2r1a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Nuf2 Nup85 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Cflar Ppp2r5a Sec13 B9d2 Bub3 Bub1 Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Plat Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Cenpo Cenpn Cenpm Mis12 Nup133 Evc2 Cenpl Zwilch Iqce Evc Cenpk Gas8 Cenpi Efcab7 Cenph Smc1a Cenpf Cenpe Hhip Boc Gas1 Avpr2 Cdon Oxtr Avpr1b Avpr1a Oxt Avp Dsp Pld2 Tjp1 Casp3 Dsg2 Dsg1a Tjp2 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Nrg2 Nrg4 Gtf2f1 Nrg3 Memo1 Pxn H2ac20 Tert Trib3 Prkaa1 Prkaa2 Myc Akt3 Akt2 Akt1 Jund Hif1a Tcf7l1 Tcf7l2 Lyn Ddx4 Mov10 Yes1 Cftr H2ac12 H2ac11 Ago4 Ago3 Gfap Ago2 Ago1 H2ac15 H3c7 Ezh2 H2ax Csnk2a2 Axin2 Suz12 Cd28 Ccr5 Ash2l Rac1 Hist1h2bp Jak1 Fos Vav1 H2aj Os9 Pik3r5 Pik3r6 Pik3r1 Maged1 Pik3r2 Yap1 Pak1 Sel1l Fosb Pak3 Pak2 H2bc9 H2bc7 H2bc8 Grap2 H2bc3 Mib2 Rac2 S100a9 S100a8 Stat3 Stat1 Rictor H2ab2 Mycn Derl2 H2bu2 Cd86 Cd80 Spop Vcp Tcf7 Cx3cr1 Prkag3 Pik3cg Pik3cb Igf1r Pik3cd Prkag1 Prkag2 Pik3ca Wwtr1 Hist2h2aa1 Erlec1 Disp2 Prr5 Hhat Ywhag Lrig1 Ptprk Pdpk1 Pag1 Epas1 Fam83a Dpy30 Wdr5 Spry1 Csnk2b Eed Them4 Cd274 Gsk3b Lck Mlst8 Lef1 H2bc14 Ptpn6 Mtor Ptpn11 Fyn Csk H2bc21 Tnrc6c H2bc26 Rbbp5 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Mapkap1 Prkab2 Prkab1 Nelfb Ccnk Tbp Gtf2a1 Gtf2a2 Ncbp2 Ncbp1 Myl12b Myh11 Cdk9 Ccnt2 Ccnt1 Tpm3 Mylk Myl6 Gja1 Itgb5 Cct6a Anxa1 Tuba1b Ptpn12 Galnt3 Muc13 Rgs9 Rgs6 Rgs7 Cct2 Actb Thbs2 Sphk1 Gna11 Gna15 Gna14 Arl2 Muc20 Gnaq Cct7 Lfng Trp53 Ednra Rgs11 Npff Trhr Rgsl1 Gnrh1 Nmbr Fpr2 Ptgfr Agtr1a Nmb Lpar6 Xcr1 Lpar5 Ppan Grpr Gpr17 Nms Nmu Cckar Nmur2 Gnrhr Aaas Nmur1 Ntsr2 Ntsr1 Brs3 Ptger1 Gpr132 Edn2 Cckbr F2 Hcrt Grp Kiss1r Nps Ptafr Npffr1 Npffr2 Gprc6a Prok2 Gpr4 Qrfp Prok1 Npsr1 Agt P2ry10 F2rl1 Gast F2rl2 F2rl3 Prokr2 Ghsr Prokr1 Rgs4 Rgs5 Rgs2 Hsp90aa1 Rgs3 Gpr65 Rgs1 Gpr68 Uts2 Tacr1 Tacr3 Tacr2 Casr F2r Ffar3 Ffar4 Bdkrb2 Tgfb1 Ffar1 Bdkrb1 Ffar2 Nts Kng2 Grk5 Tac3 Tac1 Opn4 Pmch Ptpro Ltb4r1 Clta Ltb4r2 Trh Parp1 Cltc Grm1 Grm5 Lpar4 Lpar3 Lpar2 Lpar1 Mmp3 Qrfpr Xcl1 Kiss1 Rgs21 Rgs17 Rgs18 P2ry6 Rgs19 Rgs13 P2ry2 Rgs16 P2ry1 Hcrtr2 Hcrtr1 Uts2b Cck Cbfb Uts2r Zap70 Ulk3 Dzip1 Spopl Fasn Amer1 Icmt Ddx39b Srrm1 Tial1 Tia1 Esrp2 Rbfox2 Sox2 C5ar2 C5ar1 Cd19 Trpc6 Trpc7 Trpc3 Itsn2 Grk3 Fn1 Lama5 Lamb2 Lama1 Picalm Lamc3 Lamb3 Lama2 Lama3 Lama4 Lamc1 Lamb1 Lamc2 Epn1 Arf6 Eps15l1 Trip10 Cttn Ptprj Pip5k1c Traf6 Prkcq Kdm4c Rasgrp4 Rasgrp2 Dhrs4 Tab3 Tab2 Ide Tab1 Ednrb Mark3 Ywhah Hdac1 Sox9 Edn1 Edn3 Mc1r Rps6ka1 Kit Mc5r Ywhaz Mc4r Pomc Id1 Snai2 Mc3r Cav1 Cga Tshb Vav3 Vav2 Dbn1 Hnrnpf Spen Twf1 Pde5a Msi2 Hnrnpm Tmod3 Myo6 Txnl1 Phip Rbmx Actg1 Cops4 Hnrnph1 Tra2b Cops2 Stk38 Hsp90ab1 Cpsf7 Hnrnpc Actn1 Cdc37 Rhobtb2 Rock2 Rhobtb1 Rock1 Vim Rnf20 Dusp16 Furin Ptbp1 Pcsk5 Pcsk6 Tgfbr1 Tgfbr2 Aatf Rptor Ppm1a Eif4ebp1 Eif4g1 Stradb Cab39 Prdm4 Strada Pgk1 Slc38a9 Bcap31 Lamtor5 Akt1s1 Lamtor4 Rraga Rragb Eef2k Lamtor1 Rragc Lamtor2 Rragd Tsc2 Tsc1 Stk11 Eif4b Eif4e Cab39l Apc Hnrnpa1 Scd1 Gpam Sp1 Sfpq Dlg1 Dlg3 Mmp9 Dlg4 Porcn Khdrbs1 Khdrbs3 Khdrbs2 Birc3 Birc2 Tradd Traf2 Xiap Tnfsf10 Tnfrsf10b Fadd Ube2l3 Gzmb Flot2 Flot1 Elane Rhot2 Rap1gds1 Itch Mfn1 Mfn2 Trak2 Tns4 Tns3 Casp8 Dock7 Ripk1 Stub1 Mrtfa Bax Senp1 Fas Samm50 Ptpn7 Mtx1 Ptpn2 Ptpn18 Ptpn13 Atp2a1 Mecom Atp2a3 Atp2a2 Stap2 Mob1a Lats1 Mob1b Lats2 Camk2g Amotl2 Camk2d Amotl1 Ahcyl1 Stk4 Sav1 Camk2b Stk3 Camk2a Ltk Tnk2 Prkaca Ccl12 Itpr3 Itpr2 Itpr1 Mapk7 Mapk8 Myog Myod1 Cdkn2b Myf6 Tcf4 Myf5 H3c8 Pard6b Il6 Ring1 Cbx8 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Phc3 Mdm2 Bmi1 Rack1 Rps6ka3 Rps6ka2 Farp2 Rnf2 Cdh5 Mapkapk5 Tle1 Tiam1 Bdnf Gab1 Plcg1 Frs3 Ntf4 Ntrk2 Dock3 Ntf3 Grin2b Egf Bcl2 Bcl2l1 Areg Dll4 Jag2 Jag1 Adam10 Neurl1b Egr1 Adam17 Neurl1a Dll1 Mib1 C3 C5 Vps35 Vps29 Csn2 Wls Stmn1 Adap1 Pdgfd Rab4a Bex3 Gga3 Cilp Vps26a Thbs3 Thbs4 Tmed5 Mxd4 Slc1a5 Ulk1 Uaca Zdhhc9 Golga7 Irs4 Igf2 Igf1 St3gal4 Syvn1 Eepd1 Arl4c Kdm1b Kdm3a Apod Adora2a Camk4 Pdyn Galr2 Dlg2 Galr3 Actn2 Galr1 Fpr1 Nefl Tas1r2 Grin1 Tas1r1 Grin2d Tas1r3 Pnoc Tas2r131 Tas2r135 Tas2r137 Tas2r136 Myh9 Gpr18 Tas2r140 Gpbar1 Tas2r4 Myl12a Fpr-s1 Erbb2 Ptger4 Tas2r7 Ptger2 Myb Ptger3 Mtnr1a Mtnr1b Agtr2 Gpha2 Gpr37 Gpr35 Gpr31 Rgr Ccl17 Ccl11 Ptgdr2 Axin1 Cx3cl1 Ccl28 Gata3 Ccl25 Pip4k2b P2ry13 Ccl22 P2ry12 Pip4k2a Ccl20 Gpr55 P2ry14 Cited1 Lhcgr Oxgr1 Sucnr1 Prlhr Ece1 Psap Ccl7 P2ry4 Ccl5 Ccl4 Ccl3 Ccl2 Gatad2a Ccl1 Junb Gatad2b Mrgprd Ret Rrh Ptgdr Apln Tas2r39 Oprd1 Tas2r38 Cmklr1 Gli3 Sstr5 Gli2 Sstr4 Kel Rarb Sstr2 Sstr1 Gpr183 Ppard Lhb Ppbp Ccr10 Nln Tas2r16 Wwox Tas2r13 Gps2 Ppy Ccr1 Tcf12 Npbwr1 Fshb Mc2r Fshr Ccr9 Pf4 Kat2b Ccr8 Rarg Ccr7 Ccr6 Kat2a Ccr4 Ccr3 Wwp1 Ccr2 Plppr1 Gal Plppr4 Socs3 Plppr5 Plppr2 Plppr3 Penk Npb Men1 Opn1mw Npw Usp2 Mas1 Tas2r40 Usp7 Tas2r41 Hcar1 Hcar2 Csf2 Cxcr1 Cxcr2 Npy1r Cxcr3 Xk Cxcr5 Cxcr6 Itga5 Oprl1 Prlh Cxcl11 Hebp1 Cxcl10 Aplnr Steap3 Opn3 Ccrl2 Gper1 Opn5 Pyy Abl1 Adora1 Adora3 Cxcl16 Cxcl13 Tas2r119 Npy5r Cdk8 Grm3 Grm2 Grm4 Grm7 Grm8 Npy4r Ptgir Sin3a Tas2r120 Tshr Il2ra Cxcl9 S1pr3 Cxcl1 Lbr S1pr2 S1pr5 Cxcl2 S1pr4 Cxcl3 Cxcl5 Skil Tas2r107 Gpr37l1 Npy2r Ackr3 Ptpn1 Ackr4 Cnr1 Ackr1 Ackr2 Atp1b4 Cnr2 Cort Pml Ins2 Capzb Rnf111 Gipc1 Hells Tgfb2 Inha Tgfbr3 Mmp14 Mmp16 Timp1 Timp2 Acvr2a Klf16 Inhba Fkbp5 Sgk1 Itga8 Npy Pmepa1 Tgfb3 Vegfa Ltbp3 Ltbp2 Ltbp4 Ltbp1 Uchl5 Itgb8 Itgb6 Usp15 Bambi Mtmr4 Usp8 Ube2d3 Nedd4l Irak1 Esr2 Ybx1 Tgif1 Tgif2 Bag4 Dnajb1 Itga2b Rbl1 Hes1 Trim33 Prdm1 Maml1 Maml2 Hdac11 Hdac10 Sfn Rbpj Hey2 Hey1 Rspo3 Usp9x Pelp1 Ncor2 Spp1 Mbd3 Yy1 Ski Mamld1 Egfr Serpine1 Kmt2b Pin1 Tnf Tnfrsf1a Fcer2a Hdac2 Hdac5 Hdac7 Hdac6 Hdac9 Hdac8 Smarca4 Srf Pdgfb Sparc Pten Sst E2f4 E2f5 Vegfd Vegfc Vegfb Col1a2 Rapgef4 Rapgef3 Ccnc Cfl1 Thbs1 Pck1 Apoe Prmt1 Foxo4 Foxo1 Plg Bcar1 Tgfa Aamp Smurf2 Smurf1 Nr4a1 Runx3 Grb7 Vangl2 Aldh3a2 Epsti1 Stip1 Rnd1 Wdr6 Rras2 Stmn2 Kctd6 Kif14 Ccdc88a Tmem59 Fam83b Ubxn11 Plxna1 Fam135a Cpd Dlg5 Ankrd26 Pkp4 Rxrb Oprm1 Rxrg Il2 Smad1 Smad2 Bmp2 Smad3 Smad4 Tcf3 Smad6 Smad7 Notch4 Chd3 Chd4 Notch2 Notch3 Nr2e1 Rest Kras Mta2 Casp2 Oprk1 Brap Phb1 Apbb1ip Arrb2 Iqgap1 Arrb1 Jak2 Fgb Fga Rap1b Ksr1 Vwf Cnksr2 Cnksr1 Fgg Araf Itgb3 Pebp1 Raf1 Tln1 Map3k11 Vcl Atp6v0b Atp6v0a2 Myh14 Atp6v0a4 Myh10 Atp6v1g3 Hmox2 Limk1 Atp6v0e2 Limk2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Atp6ap1 Atp6v1e2 Atp6v1e1 Tcirg1 Tle4 Tle2 Tfrc Atp6v1a Dtx1 Atp6v1b2 Dtx2 Atp6v0d2 Dlk1 Dner Atp6v0d1 Atp6v1b1 Sharpin Atp6v0e1 Usp21 Traf1 Atp6v1g2 Spata2 Atp6v1g1 Rnf31 Usp4 Atp6v1f Cyld Otud7b Atp6v1d Nedd8 Tnfaip3 Atp6v1h Tbk1 Dtx4 Dhrs3 Aldh1a2 Rdh11 Epo Aldh1a3 Rdh10 Akr1c18 Aldh8a1 Rdh13 Dbt Rdh14 Cyp26b1 Dld Cyp26c1 Rdh16f2 Cyp26a1 Rdh5 Crabp1 Dhrs9 Sdr16c5 Arhgap10 Ppp3cc Col6a1 Col4a3 Col6a2 Col4a4 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 96%168179 Toll Like Receptor TLR1:TLR2 Cascade Tlr4 App Ikbkb Jun Peli1 Ikbkg Map3k7 Traf2 Cd14 Btk Nfkb1 Socs1 Skp1 Fbxw11 Rela Btrc Casp8 Ubc Nfkbib Irak1 Nfkbia Cul1 Traf6 Ube2n Chuk Ube2v1 Trp53 Tab3 Sigirr Tab2 Tab1 S100a1 Irak3 Cd36 Tirap Rps6ka1 Tifa Alpk1 Nfkb2 Fos Fgb Fga Mapk9 Mapk7 Fgg Mapk8 S100a9 Elk1 S100a8 Tlr1 Tlr6 Tlr2 Map3k8 Mapk1 Mapk3 Rps6ka3 Mapkapk3 Rps6ka2 Mapkapk2 Map2k7 Mapk14 Map2k6 Ppp2cb Ppp2ca Map2k4 Map2k3 Mapk10 Map2k1 Mapk11 Ripk2 Myd88 Rps6ka5 Nkiras1 Atf2 Nkiras2 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Ppp2r1a Peli2 Peli3 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Usp18 Ppp2r5d Ly96 Mef2c ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures Pcolce Col4a1 Col24a1 Col5a1 Col4a2 Col9a2 Mmp13 Col9a3 Ctsl Mmp9 Col6a6 Col8a1 Col6a3 Col4a5 Col9a1 Col8a2 Lamb3 Lama3 Mmp3 Lamc2 Lox Loxl2 Loxl1 Loxl4 Loxl3 Bmp1 Tll2 Tll1 Mmp20 Pxdn Plec Itga6 Cd151 Itgb4 Col15a1 Col18a1 Col11a1 Col11a2 Ctsb Ctss Col10a1 Col2a1 Col3a1 Col1a2 Col27a1 Col1a1 Col6a1 Col5a2 Col4a3 Col7a1 Col6a2 Col5a3 Mmp7 Col4a4 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD Abcd1 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 96%4641257 Degradation of AXIN Rnf146 Tnks2 Psma4 Tnks Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Smurf2 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Axin2 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Axin1 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels Kcnj10 Kcnj1 Kcnj16 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 96%5689896 Ovarian tumor domain proteases Trp53 Yod1 Esr1 Rnf128 Otud7b Rhoa Otud3 Tnfaip3 Otud7a Ripk2 Traf3 Ikbkg Zranb1 Cdk1 Ube2d1 Apc Ifih1 Rnf135 Vcpip1 Tnip2 Trim25 Otub1 Mavs Nod2 Rigi Pten Nod1 Vcp Otub2 Ripk1 Ubc Tnip3 Tnip1 Traf6 Otud5 PLATELET DEGRANULATION%REACTOME%R-HSA-114608.5 Platelet degranulation Scg3 Qsox1 Selp Lgals3bp Ppia Cyrib Sccpdh Srgn Wdr1 Maged2 Pecam1 Endod1 Aplp2 App Clec3b Mmrn1 Tgfb2 Habp4 Fn1 Plg Ttn Rarres2 Cdc37l1 Timp1 Plek Tagln2 Itih4 Itih3 Tgfb3 Vegfa Tuba4a F5 F8 Alb Serpina1d Pfn1 A2m Apool Igf2 Igf1 Cap1 Cd36 Itga2b Actn2 Lamp2 Pcdh7 Cd9 Fgb Fga Vwf Abcc4 Tgfb1 Fgg Itgb3 Kng2 Psap Aldoa Tln1 Vcl Actn1 Ppbp Hgf Cyb5r1 Pf4 Tf Serpine1 Hspa5 Pros1 Gas6 Egf Cd109 Nhlrc2 Phactr2 Stxbp2 Tex264 Fermt3 Vti1b Brpf3 Lefty2 Chid1 Manf A1bg Pdgfb Islr Sparc Pcyox1l Apoh Hrg Gtpbp2 Ecm1 Ola1 Orm3 Ctsw Serping1 Calu Rab27b Selenop Lhfpl2 Actn4 Clu Sytl4 Ahsg Spp2 Vegfd Vegfc Vegfb Serpina3n Cd63 Timp3 Tor4a Cfd Fam3c Flna Serpinf2 Cfl1 Apoa1 Thbs1 F13a1 Tmx3 Anxa5 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956551 OTC leader sequence variants cause OTC deficiency Otc OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling Prkaca Itpr3 Camkk1 Itpr2 Camkk2 Itpr1 Ppp3r1 Ppp3ca Ppp3cb Prkcg Prkx Gnal Ppp1ca Cdk5 Prkacb Adcy3 Adcy4 Gna11 Adcy1 Gna15 Adcy2 Gna14 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Mapk1 Gnaq Gnai2 Gnai1 Gnai3 Prkar1b Oprm1 Ppp1r1b Ppp2cb Ppp2ca Gnat3 Pde4a Prkar2b Plcb3 Plcb2 Pde4c Plcb1 Pde4d Gng10 Prkca Gng3 Gng2 Prkar1a Gng4 Plcb4 Gng7 Gng8 Camk4 Pdyn Ppp2r1b Ppp2r1a Prkar2a Pla2g4a Grk2 Pomc Pde1b Gngt1 Pde1c Prkcd Gngt2 Pde1a Camk2g Camk2d Ahcyl1 Camk2b Camk2a Gnb2 Ppp3cc Gnb1 Ppp2r5d Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 96%392518 Signal amplification Gnat3 P2ry12 Gng10 Gng3 Gng2 Tbxa2r Gng4 Gna13 Gng7 Aamp Gng8 Pla2g4a Gngt1 Gngt2 P2ry1 Gna11 Gna15 Gna14 Gnb2 Gnaq Gnb1 Gnb4 Gnai2 Gnb3 Gnai1 Gnb5 Gng11 Gnai3 Gng12 Mapk14 Gng13 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation Tlr4 Tapbp Sec61b Itgb5 Rnf111 Btk Prkn Fbxw10 Fbxw4 Fbxw5 Ube2l3 Fbxw7 Mylip Fbxw9 Erap1 Itch Fbxw2 Rbx1 Ube2d3 Fbxo4 Stub1 Fcgr1 Itgav Fbxo6 Nedd4l Fbxo32 Fbxl3 Fbxl5 Cul2 S100a1 Cd36 Tirap Trim63 Ube2b Kbtbd7 Cul3 Calr Canx Fzr1 Vamp8 Skp2 Mrc1 Hspa5 Cdc20 Pik3c3 Myd88 Pik3r4 Lrr1 Nedd4 Rnf220 Fbxl20 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb Sh3rf1 Ctss Trim11 Ube2l6 Mex3c Rnf126 Dcaf1 Rnf123 Ubac1 Lnpep Atg7 Rnf114 Rnf115 Hace1 Sec13 Siah2 Keap1 Kbtbd13 Dzip3 Mkrn1 Ube2g2 Ube2g1 Rnf138 Rnf130 Kbtbd8 Ctsl Gan Fbxw8 Anapc13 Det1 Klhl9 Psma4 Rbck1 Ikbkb Arih2 Psma3 Rlim Psma6 Klhl2 Psma5 Ube4a Psma2 Spsb2 Psma1 Trim9 Ikbkg Spsb1 Trip12 Spsb4 Psmd12 Cd14 Lrsam1 Psmd11 Huwe1 Psmd14 Ube2j2 Psmd13 Smurf2 Ube2j1 Sec22b Skp1 Smurf1 Socs1 Kctd7 Psmb5 Ube2w Psmb4 Ube2m Psmb7 Ube2k Psmb6 Rnf182 Psmb1 Ube2o Psmb3 Ltn1 Psmb2 Ube2h Mgrn1 Fbxw11 Ube2f B2m Sec31a Ube2a Fbxo10 H2-Q10 Btrc Fbxo11 Psma7 Fbxo17 Psmc6 Lmo7 Psmc5 Rnf41 Psmc2 Ube3d Psme2 Psmc1 Ube3c Psme1 Psmc4 Lrrc41 Psmc3 Kctd6 Klhl13 Ube2z Ubc Psmb10 Klhl11 Psmd7 Ube3b Psmd6 Ube3a Traip Fbxo21 Becn1 Psmd8 Ubox5 Psmd3 Fbxo22 Psmb9 Psmd2 Ubr1 Psmb8 Psmd1 Rnf19a Ubr2 Glmn Adrm1 Ubr4 Sem1 Fbxo27 Cul1 Ube2n Ube2v2 Uba5 Chuk Uba6 Uba7 Cdc34 Trim69 Ube2v1 Trim71 Klhl25 Ube2e3 Ube2e2 Btbd6 Rnf19b Klhl21 Klhl22 Klhl20 Fbxl8 Fbxo30 Fbxo31 Fbxl4 Fbxl7 Lonrf1 Zbtb16 Uba1 Uba3 Tpp2 Cul5 Cul7 Fbxo41 Traf7 Hectd1 Fbxo44 Hectd2 Hectd3 Thop1 Znrf1 Trim50 Dtx3l Blmh Rnf14 Klhl41 Klhl42 Ufl1 Fbxo40 Npepps Ube2q2 Ube2q1 Btbd1 Pja2 Pja1 Arel1 Rnf144b Fbxo2 Asb12 Asb11 Siah1a Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc2 Herc3 Ube2r2 Herc1 Rnf6 Rnf7 Rnf4 Fbxo7 Fgb Herc6 Fga Fbxo9 Trim21 Vhl Fbxl12 Fbxl13 Fbxl14 Fgg Fbxl15 Fbxl16 Trim39 Fbxl18 Fbxl19 Trim37 Mib2 Trim36 Trim32 Anapc5 S100a9 Trim41 Anapc4 S100a8 Asb9 Anapc1 Asb8 Anapc2 Asb7 Anapc11 Asb6 Tlr1 Ube2c Asb5 Anapc10 Tlr6 Rnf25 Tlr2 Anapc7 Asb4 Asb3 Cdc27 Asb2 Ube2d1 Rchy1 Cdc16 Asb1 Lnx1 Ube2e1 Cdc23 Wwp1 Ncf1 Socs3 Ncf2 Ncf4 H2-M5 H2-M3 Snap23 Cyba Cybb H2-Q1 Sar1b Sec23a Vamp3 Rnf34 Pdia3 Sec24d Mrc2 Ly96 Sec24c Sec61a2 Sec61a1 Tap2 Sec24b Tap1 Cd207 Eloc Sec24a Stx4 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 96%9936686 Aggregated β-amyloid interacts with fibrinogen Fgb Fga Fgg ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399710 Activation of AMPA receptors Gria2 Gria4 Gria3 Gria1 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 96%389356 CD28 co-stimulation Ppp2cb Ppp2ca Them4 Pak1 Lck Mlst8 Pak3 Pak2 Ppp2r5e Mtor Grap2 Trib3 Fyn Akt3 Akt2 Akt1 Map3k14 Rictor Map3k8 Mapkap1 Lyn Ppp2r1b Ppp2r1a Yes1 Cd86 Cd80 Pik3cg Pik3cb Pik3cd Cd28 Pik3ca Rac1 Vav1 Prr5 Ppp2r5d Ppp2r5c Ppp2r5b Pik3r5 Pdpk1 Pik3r6 Ppp2r5a Pik3r1 Pik3r2 Ctla4 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation Rps5 Eif3m Eif3i Eif3l Eif3k Eif3f Eif3e Rps25 Eif3h Rps26 Pabpc1 Eif3g Eif3b Eif3a Rps21 Eif3d Eif3c Eif4h Eif3j2 Eif4b Rps15a Eif4e Eif1ax Eif4a2 Eif2s3x Eif4a1 Eif2s2 Eif2s1 Rps27l Rps27 Rps3 Rps4x Rps14 Rps16 Rps18 Rps19 Rpsa Rps10 Rps11 Eif4g1 Rps9 Rps7 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 96%2514853 Condensation of Prometaphase Chromosomes Smc4 Smc2 Ncaph Ncapd2 Cdk1 Ccnb2 Csnk2a2 Csnk2b NOSIP MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203754.3 NOSIP mediated eNOS trafficking Nosip Nos3 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors Gnat3 Gng10 Kcnj3 Kcnj2 Gnal Gng3 Gng2 Gng4 Gng7 Gng8 Gabbr1 Gabbr2 Gngt1 Gngt2 Adcy3 Adcy4 Adcy1 Adcy2 Kcnj9 Adcy7 Kcnj6 Adcy8 Kcnj5 Adcy5 Kcnj4 Adcy6 Adcy9 Gnb2 Gnb1 Kcnj10 Gnb4 Gnai2 Gnb3 Gnai1 Gnb5 Gng11 Gnai3 Kcnj12 Gng12 Gng13 Kcnj15 Kcnj16 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.3 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Med27 Med12 Med13 Med14 Med10 H2bc9 Havcr2 H2bc7 H2bc8 H2bc3 Med16 Angptl4 Med17 Ncor2 Plin1 Mgll Cdk5 H2ab2 Kdm6a Fabp4 Pex11a H2bu2 Ncoa3 Lpin1 Elovl5 Cidec Nr5a2 Dgat2 Gps2 Rb1 Ppargc1b Lipe Plin4 Acsl1 Lpl Pnpla2 Thrsp Kmt2c Phlda1 Hist2h2aa1 Dpy30 Agpat2 Wdr5 Med30 Med31 Adipoq Kmt2d H2bc14 H2ac20 Rxra Cd36 H2bc21 H2bc26 Pagr1a Rbbp5 Ncor1 Abl1 Paxip1 Ep300 Cdk8 Tbl1x Ajuba Cebpa H2ac12 H2ac11 Plin2 Hdac3 Scd1 H2ac15 Ncoa2 H3c7 Ncoa1 H2ax Tbl1xr1 Ncoa6 Ash2l Hist1h2bp Med1 H2aj Ppargc1a Pdk4 Ccnc Crebbp Med23 Med4 Med24 Med6 Med20 Sirt1 Gpam SIGNALING BY PTK6%REACTOME%R-HSA-8848021.4 Signaling by PTK6 Nrg3 Nr3c1 Elmo2 Sfpq Rasa1 Pxn Arhgap35 Nras Khdrbs1 Khdrbs3 Khdrbs2 Crk Hras Rhoa Pelp1 Egf Bcar1 Arap1 Ereg Stat3 Hbegf Akt1 Btc Hif1a Ccne1 Nrg1 Stap2 Cbl Ccnd1 Gpnmb Cdk4 Ubc Lrrk2 Egfr Cdk2 Erbb2 Ptk6 Rac1 Ptpn1 Srms Cdkn1b Elmo1 Socs3 Epas1 Dok1 Dock1 Nrg2 Nrg4 APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 96%75153 Apoptotic execution phase Satb1 Bcap31 Gsn Bmx Pak2 Casp7 Gas2 Dbnl Add1 Plec H1f2 Birc2 H1f3 Clspn Kpna1 Fnta Stk26 Stk24 Hmgb2 Dffa Lmnb1 Dnm1l Dffb Apc Acin1 Ctnnb1 Prkcd Dsp H1-1 Rock1 H1-0 Tjp1 Vim Casp3 Casp8 Pkp1 Dsg2 Cdh1 H1-5 Dsg3 Dsg1a H1-4 Tjp2 Casp6 Ptk2 Kpnb1 Prkcq Sptan1 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation Fn1 Itgb1 Itga5 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Gsk3b Csnk1e Csnk1a1 Nek11 Psma4 Plk3 Psma3 Mapk11 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Chek2 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Cdc25a Psmb1 Psmb3 Psmb2 Fbxw11 Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Chek1 Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Mapk14 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System Tlr4 Nfatc1 Nfatc3 Ppia Nfatc2 Rasgrp1 Cnn2 Ppp3r1 Ppp3ca Ppp3cb App Jun Cyb5r3 Capn1 Prkacb Ap2a2 Npc2 Slc44a2 Bst1 A2m Copb1 Idh1 Plaur Gsn Adgre5 P2rx1 Cpne1 Cpne3 Gns Casp9 B4galt1 Plac8 Snap29 Manba Rab10 Pgam1 Rab14 Gaa Man2b1 Hp Dera Aldoc Aldoa Hexb Prtn3 Surf4 Glb1 Aoc1 Cd44 Pygb Agl Pygl Arsb Gusb Tasl Rbsn Eea1 Irf5 Cd300a Pros1 Gyg1 Itgax Itgam Pdxk Ppp2cb Ppp2ca Itgb2 Rab27a Cd47 Hpse Dync1li1 Naprt Hk3 Dsn1 Atp8a1 Dynll1 Ppp2r1b Atp11b Pgm2 Ppp2r1a Atp11a Pgm1 Dync1h1 Tkfc Ppp2r5d Pfkl Atp7a Ano6 Galns Plau Serpinb6a Txk Traf3 Ticam2 Ticam1 Cd14 Ikbke Tank Optn Apeh Commd9 Dsp Pld2 Casp3 Pkp1 Dsg1a Aprt Polr2h Pnp Polr2e Lpcat1 Polr2f Ampd3 Polr2k Mmp25 Commd3 Agpat2 Asah1 H2ac20 Adam8 Mmp8 Lyn Yes1 H2ac12 H2ac11 Lamp2 H2ac15 H3c7 H2ax Sell Sirpa Nfkb2 Olr1 Rac1 Hist1h2bp Fos Vav1 Trem1 Pik3r1 Pik3r2 Sirpb1b Cd3g Pak1 Magt1 Pak3 Pak2 Armc8 H2bc9 H2bc7 H2bc8 Grap2 H2bc3 Cd300lb Rac2 S100a9 S100a8 Map3k14 Klrk1 H2ab2 Map3k8 Lair1 Tec Ifih1 H2bu2 Sike1 Cd300e Rnf135 Trim25 Mavs Ttr Rigi Vcp Klrd1 Siglec12 Rab5c H2az1 Tspan14 Rab5b Pik3cb Cst3 Oscar Pik3ca Prss2 Art1 Hist2h2aa1 Mme Pdpk1 Atp6ap2 Ddost Csnk2b Lck Anpep H2bc14 Ptpn6 Rhoa Cd4 Cd180 Ptpn11 Ly86 Fyn Lbp Cd209a Bpi H2bc21 Relb Rps6ka5 H2bc26 Icam2 Rab7 Rhog Kcnab2 Iqgap2 Stbd1 Pld1 Dock1 Dock2 Elmo2 Ndufc2 Muc15 Muc13 Cyfip1 Cct2 Actb Fabp5 Cfp Dgat1 Muc1 Srp14 Muc4 Muc6 Itgav Muc20 Ptk2 Slco4c1 Anxa2 Cct8 Trp53 Mgst1 Tubb4b Fpr2 Nck1 Cap1 Ckap4 Myo9b F2 Ptafr Panx1 Ctsa Tollip Slc11a1 Kpnb1 Hsp90aa1 Neu1 Kng2 Isg15 Elk1 Arhgap9 Dnajc3 Fcer1a Ms4a2 Hspa1a Mospd2 Nlrp1a Ctsz Vamp8 Txndc5 Dnm2 Itk Hspa8 Pdzd11 Lcp2 Lat2 Vnn1 Arhgap45 Faf2 Rhof Slc15a4 Pik3c3 Hgsnat Arsa Gab2 Tlr9 Pik3r4 Dhx58 Rnf216 Cr2 Mmtag2 Padi2 Serping1 Nbeal2 Cfh C5ar2 Prdx4 Pgrmc1 Cfi C5ar1 Cystm1 Clu Flg2 C6 Ptprn2 C7 Pa2g4 C9 S100a11 Cd46 Rnase2a Ube2l6 Gdi2 Cfhr1 Rnase2b Cfhr2 Clec12a Tmt1a Cd81 C8b Syngr1 C8a Glipr1 Tmc6 Cpn1 Rab31 Pglyrp1 Cpn2 C8g Atg7 Ptges2 Grn Cd19 Enpp4 Cpb2 Ypel5 Nfam1 Aga Pigr Crispld2 Ormdl3 Lrg1 Plekho2 Adgrg3 Epx Kcmf1 Serpinb1a Serpinb12 Trpm2 Bri3 Serpinb3d Ptprb Ghdc Lamp1 Arl8a Nit2 Chi3l1 Acp3 Vtn Crisp1 Rab18 Olfm4 Atad3a Fgl2 Dnase1l1 Huwe1 Gm2a Slpi Nhlrc3 Socs1 Mcemp1 Scamp1 Krt1 Prcp Ube2m Ap1m1 Tmem179b Ube2k Cant1 Unc13d Calm4 Tmem30a Vat1 Prg3 B2m Prg2 Rap2b Rap2c Ptprj Camp Abca13 Cd53 Stk11ip Irag2 Cstb Gca Rnaset2a Erp44 Creg1 Mpo Cd68 Dok3 Hebp2 Cd93 Cotl1 Dpp7 Aldh3b1 Ubr4 Tarm1 Degs1 Traf6 Ube2n Tmbim1 Cracr2a Prkcq Cpped1 Rasgrp4 Rasgrp2 Uba7 Mvp Ms4a3 Cdc34 Ube2v1 Pdap1 Tmem63a Tab3 Tab2 Cmtm6 Tab1 Tnfaip6 Vps35l Ostf1 Ptx3 Gla Alad Uba3 Pafah1b2 Actr10 Rps6ka1 Nos2 Tyrobp Ptprc Trem2 Vav3 Impdh1 Nme2 Trim21 Vav2 Pcbp2 Trim32 Tlr1 Tlr6 Tlr2 Actg1 Hsp90ab1 Chrnb4 Rock1 Ltf Tomm70 Ncf1 Ncf2 Ncf4 Brk1 Cab39 Baiap2 Nckap1l Lamtor1 Lamtor2 Nckap1 Wasf2 Wasf1 Snap25 Snap23 Cyba Abi2 Abi1 Cybb H2-Q1 C1qbp Bst2 Slc2a5 Psen1 Ncstn Elmo1 Hck Ppie Clec5a Ddx3x Mmp9 C3ar1 Il18 Birc3 Plcg2 Birc2 Wipf3 Peli1 Bpifb1 Arpc1b Bpifb6 Actr2 Bpifa1 Arpc1a Bpifa2 Actr3 Traf2 Wipf2 Wipf1 Sdcbp Rnase6 Btk Myo5a Arpc3 Fadd Arpc2 Nlrp3 Pstpip1 Eppin Cyfip2 Arpc5 Elane Arpc4 Itln1 Itch Ctsg Ripk3 Chga Siglec15 Casp8 Leap2 Casp4 Lpo Casp1 Ripk1 Gsdme Fcgr1 Gsdmd Fcgr3 Fcgr4 Il1b Syk Mefv Fgr Pglyrp2 Myh2 Pglyrp3 Pglyrp4 Myo1c Reg3b Reg3g Nckipsd Was Wasf3 Pycard Sigirr Wasl Sugt1 P2rx7 Myo10 S100a1 Irak3 Cd36 Frk Tirap Pld4 Ahcyl1 Nos1 Prdx6 Hvcn1 Prkaca Itpr3 Itpr2 Itpr1 Mapk9 Mapk7 Atox1 Mapk8 Txn Ifnb1 Rps6ka3 Rps6ka2 Map2k7 Map2k6 Map2k4 Map2k3 Mapk10 Pkm Plcg1 Bcl2 Ripk2 Myd88 Bcl2l1 Acly Nkiras1 Nkiras2 Eef2 Lrrc14 Ecsit Vrk3 Ikbip Adam10 Map3k1 Peli2 Peli3 Tlr5 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Usp18 Alox5 Ilf2 C3 C4a C5 Cfb C2 Chit1 Mgam Fuca2 Bpifb2 Ist1 Tbc1d10c Tubb5 Pla2g6 Golga7 Nos3 Prkcsh Actr1b Ctsh Fpr1 Myh9 Tifa Alpk1 Txnip Retn Lgals3 Psap Cdk13 Polr3gl Crcp Polr3a Polr3d Gpi Polr3e Polr1c Polr3b Polr3c Polr3h Polr3f Polr1d Polr3g Polr3k Ppbp Gpr84 Ccr6 Rab9b Ccr2 Igf2r Cxcr1 Cxcr2 Rab6a Abl1 Itgal Cxcl3 Ptpn4 Nf2 Apaf1 Capza1 Capza2 Cda Timp2 Ctsd Ube2d3 Irak1 Dnm1 Sptan1 Dnm3 Nfasc F12 Klkb1 Tax1bp1 Rab3a Dnajc5 Fcer1g Pin1 Tnfrsf1b Cd177 Slc2a3 A1bg Hrg Clec7a Clec10a Clec4n Orm3 Prkcd Clec4a2 Clec4d Clec4e Clec4b2 Nlrc4 Card9 Ahsg Ctsb Ctss Unc93b1 Lgmn Hsp90b1 Serpina3n Tlr8 Cd63 Tlr7 Tlr3 Fcn2 Crp Cfd C1qb C1qa Cfl1 C1rb Gzmm Colec10 C1s2 Colec11 Qsox1 Mbl2 C1qc Stat6 Cgas Ctsk Sting1 Ctsl Trim56 Aim2 Pecam1 Ddx41 Irf7 Psma4 Dhx9 Ikbkb Prkdc Psma3 Trex1 Psma6 Dhx36 Psma5 Xrcc6 Psma2 Xrcc5 Psma1 Nlrc3 Ikbkg Ctsc Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Aamp Skp1 Malt1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Card11 Trappc1 Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Bcl10 Psmd7 Cd59b Psmd6 Nfkbib Psmd8 Psmd3 Psmd2 Psmd1 Serpina1d Nfkbia Adrm1 Sem1 Cul1 Chuk Dsc1 Dbnl Prkce Cat Diaph1 Casp2 Vapa Stom Mre11a Iqgap1 Jup Fgb Fga Stk10 Rap1b Fgg Atg5 Atg12 Raf1 Vcl Fuca1 Lta4h Defb47 Defb14 Defb36 Defb25 Defb15 Defb18 Defb29 Ube2d1 Defb19 Defb23 Defb12 Atp6v0b Ctnnb1 Rab37 Acaa1a Atp6v0a2 Slc27a2 Atp6v0a4 Atp6v1g3 Rab4b Hmox2 Limk1 Atp6v0e2 Bin2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Rab3d Ftl1 Mapk1 Fth1 Mapk3 Cand1 Rab24 Mapk12 Rap1a Mapkapk3 Mapk13 Atp6v1e2 Atp6v1e1 Mapkapk2 Mapk14 Tcirg1 Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Nras Atp6v0e1 Atp6v1g2 Map2k1 Atp6v1g1 Sos1 Cyld Crk Atp6v1f Hras Atp6v1d Mapk11 Tnfaip3 Lcn2 Atp6v1h Arg1 Mlec Tbk1 Zbp1 Irf3 Nlrp4e Dtx4 Atf2 Ep300 Hmox1 Hbbt1 Plpp4 Plpp5 Pld3 Ly96 Crebbp Mef2c Otud5 Mif Apob PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-5651801.3 PCNA-Dependent Long Patch Base Excision Repair Pcna Rfc4 Rpa2 Rfc1 Rfc2 Polb Pold4 Apex1 Pold3 Rpa3 Pole3 Pole2 Pole Pole4 Lig1 Fen1 Rfc5 Pold2 Pold1 Rfc3 Rpa1 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%2565942 Regulation of PLK1 Activity at G2 M Transition Prkaca Ccp110 Alms1 Cetn2 Nedd1 Rab8a Actr1a Tuba1a Cep43 Dctn2 Cep41 Ppp1r12a Dctn3 Plk1 Ninl Ywhae Optn Ppp1cb Cdk1 Skp1 Nek2 Fbxw11 Pcnt Tuba4a Btrc Cep250 Sdccag8 Cep78 Cep76 Cep72 Ubc Cep70 Tubb5 Plk4 Cpap Clasp1 Ywhag Pafah1b1 Cul1 Cep135 Cep131 Prkar2b Csnk1e Tubb4b Haus7 Tubb4a Haus8 Cdk5rap2 Cep57 Pcm1 Mapre1 Aurka Dynll1 Ssna1 Bora Tubg1 Ajuba Ppp2r1a Ofd1 Dync1h1 Cep63 Cep152 Haus3 Ccnb2 Haus4 Haus5 Haus6 Sfi1 Dync1i2 Csnk1d Haus1 Ckap5 Haus2 Akap9 Hsp90aa1 Cep164 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 96%9935598 FXIIa, PKa activate coagulation factors F12 Klkb1 Gp9 Gp1bb F9 Gp5 Kng2 Gp1ba DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 96%68952 DNA replication initiation Prim2 Pole4 Prim1 Pola2 Pola1 Pole3 Pole2 Pole DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism G6pc1 Nhlrc1 Galns Sgsh Sis Aldob Hgsnat Dcxr Lct Idua G6pc3 Glb1 Gns Ids Hyal1 Ppp1r3c Arsb Gusb Epm2a Naglu Ubc Gbe1 Slc37a4 Taldo1 Khk Gys1 Rpia Gys2 Gyg1 Gaa FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions Clta Cltb Ap2m1 Gja1 Cltc Dab2 Dnm1 Dnm2 SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL Crls1 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions Vegfd Vegfa Vegfc Vegfb Flt1 Pgf Flt4 Kdr ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 96%3371568 Attenuation phase Dnajb1 Hsbp1 Hspa1l Crebbp Hsp90aa1 Hsf1 Ep300 Hspa1a Hspa2 Hspa8 Fkbp4 Hsp90ab1 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 96%68875 Mitotic Prophase Smc4 Smc2 Numa1 H2bc9 H2bc7 H2bc8 H2bc3 Golga2 Lemd2 Plk1 Nup133 Vrk1 H2ab2 H3c8 Cdk1 Lmnb1 Ensa Rab2a H2bu2 Ctdnep1 Cnep1r1 Lpin3 Blzf1 Ppp2r2d Lpin2 Ncaph2 Lpin1 Arpp19 Ncapd3 Prkcb Ncapg2 Rb1 Gorasp2 Mastl Rab1a Mcph1 Rab1b Kmt5a Uso1 Mapk1 Hist2h2aa1 Gorasp1 Nup37 Nup160 Ppp2cb Ppp2ca Nup43 Ranbp2 Prkca H2bc14 Nup93 H2ac20 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr H2bc21 Nup107 Rae1 Ndc1 H2bc26 Nup42 Nup62 Nup88 Aaas Nup214 Banf1 Nup210 Nup155 Nup153 Ppp2r1b Ppp2r1a H2ac12 H2ac11 Emd Lemd3 H2ac15 H3c7 H2ax Nek9 Ccnb2 Nek6 Nup85 Nek7 Hist1h2bp H2aj Sec13 SEPARATION OF SISTER CHROMATIDS%REACTOME%R-HSA-2467813.4 Separation of Sister Chromatids Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Psma4 Cenpo Cenpn Psma3 Cenpm Espl1 Psma6 Mis12 Psma5 Nup133 Psma2 Cenpl Psma1 Zwilch Cenpk Cenpi Psmd12 Cenph Psmd11 Smc1a Psmd14 Cenpf Psmd13 Cenpe Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Pttg1 Plk1 Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Clasp1 Clasp2 Pafah1b1 Smc3 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Rad21 Kif2b Kif2c Dync1li2 Pmf1 Wapl Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Stag2 Stag1 Ppp2r1b Ppp2r1a Pds5b Pds5a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Xpo1 Nuf2 Nup85 Cdca8 Incenp Cdca5 Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%3000170 Syndecan interactions Trappc4 Actn1 Fgf2 Itgb5 Tgfb1 Prkca Itgb3 Sdc1 Cask Itgav Vtn Itgb1 Sdc4 Itga6 Sdc3 Sdc2 Tnc Itgb4 Thbs1 Itga2 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Eif2s3x Eif2s2 Eif2s1 Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Eif4g1 Eif3m Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Pabpc1 Eif3g Eif3b Eif3a Eif3d Eif3c Eif4h Eif3j2 Eif4b Eif4e Eif1ax Eif4a2 Eif4a1 Rps27 Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 96%5579017 Defective CYP11B1 causes AH4 Cyp11b1 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling Arrb1 Tgfbr3 Tgfb1 Tgfbr1 Tgfbr2 Gipc1 Arrb2 Tgfb2 DISEASES OF HEMOSTASIS%REACTOME DATABASE ID RELEASE 96%9671793 Diseases of hemostasis Adamts13 Ano6 F2 Fgb Fga Vwf F5 Fgg F8 F9 Gp1ba Ggcx Pros1 Gp9 Gp1bb Gp5 F10 Tpst1 Tpst2 Proc BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 96%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV Bckdhb Bckdha Dbt Dld SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Fgf16 Frs2 Fgf15 Them4 Irs1 Fgf18 Irs2 Fgf2 Pik3c3 Fgf1 Nras Irs4 Fgf4 Gab1 Fgf10 Igf2 Fgf3 Igf1 Fgf6 Sos1 Fgf7 Fgf9 Hras Trib3 Fgf20 Ptpn11 Gab2 Fgf23 Fgfr4 Fgf22 Akt2 Pde3b Tlr9 Pik3r4 Cilp Flt3l Pik3cb Igf1r Pik3ca Flt3 Pdpk1 Pik3r1 Pik3r2 Klb REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins F2 Pros1 Furin Gas6 Proz F7 F9 F10 Proc SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-HSA-5654699.3 SHC-mediated cascade:FGFR2 Fgf16 Fgf18 Fgf2 Fgf1 Nras Fgf4 Fgf10 Fgf3 Fgf6 Sos1 Fgf7 Fgf9 Hras Fgf20 Fgf23 Fgf22 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol Amacr Cyp46a1 Akr1c18 Cyp8b1 Slc27a5 Akr1c21 Hsd3b7 Slc27a2 Cyp27a1 Akr1d1 Akr1c6 Cyp39a1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%264642 Acetylcholine Neurotransmitter Release Cycle Slc5a7 Chat Rab3a Slc18a3 Cplx1 Unc13b Snap25 Syt1 Ppfia2 Ppfia4 Vamp2 Ppfia1 Stx1a PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432047 Passive transport by Aquaporins Mip Aqp1 Aqp9 Aqp12 Aqp7 Aqp6 Aqp11 Aqp5 Aqp8 Aqp4 Aqp3 Aqp2 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME%R-HSA-5659996.4 RPIA deficiency: failed conversion of R5P to RU5P Rpia DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH Ggt1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex Sp1 Ppp1cc Fkbp1a Itgb5 Tgfb1 Itgb3 Rnf111 Usp9x Tgfb2 Tgfbr3 Ncor2 Cdkn2b Parp1 Junb Ppp1ca Smurf2 Ppp1cb Smurf1 Ube2d1 Ube2m Ski Itga8 Pmepa1 Tgfb3 Ltbp3 Ltbp2 Ltbp4 Ltbp1 Tfdp2 Uchl5 Tfdp1 Itgb8 Itgb6 Cbl Usp15 Bambi Mtmr4 Ube2d3 Stub1 Ubc Wwtr1 Itgav Serpine1 Mapk1 Nedd4l Mapk3 Furin Tgfbr1 Tgfbr2 Ppm1a Men1 Ybx1 Smad2 Tgif1 Smad3 Tgif2 Smad4 Pard6a Pard3 Cgn F11r Rhoa Hdac1 Strap Nedd8 Smad7 Prkcz Arhgef18 Myc Rbl1 Ncor1 Ep300 Cdk8 Trim33 Ccnk Xpo1 E2f4 E2f5 Skil Itgb1 Col1a2 Cdk9 Atp1b4 Ccnt2 Ccnc Ccnt1 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 96%5602498 MyD88 deficiency (TLR2 4) Tlr4 Fgb Fga Fgg S100a1 Cd36 S100a9 Myd88 Tirap S100a8 Tlr1 Cd14 Btk Tlr6 Tlr2 Ly96 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Dll1 Notch1 Dll4 Jag2 Jag1 Adam10 Adam17 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) Slc17a8 HYALURONAN METABOLISM%REACTOME DATABASE ID RELEASE 96%2142845 Hyaluronan metabolism Gusb Hmmr Cemip Hyal5 Lyve1 Hyal2 Abcc5 Hexa Hexb Has1 Stab2 Has2 Has3 Chp1 Hyal4 Hyal3 Cd44 Hyal1 Slc17a5 Slc9a1 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K Ubiad1 Vkorc1l1 Vkorc1 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9028335 Activated NTRK2 signals through PI3K Pik3ca Bdnf Gab1 Ntf4 Pik3r1 Ntrk2 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 96%162658 Golgi Cisternae Pericentriolar Stack Reorganization Plk1 Uso1 Blzf1 Mapk1 Gorasp2 Cdk1 Rab1a Ccnb2 Gorasp1 Rab1b Golga2 Rab2a DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 96%9754119 Drug-mediated inhibition of CDK4 CDK6 activity Ccnd2 Ccnd3 Ccnd1 Cdk6 Cdk4 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs Kit ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion Cacnb2 Cacna1d Gng10 Cacna1c Gng3 Gng2 Gng4 Gng7 Gng8 Gngt1 Gngt2 Adcy5 Adcy6 Gnb2 Gnb1 Gnb4 Gnai2 Gnb3 Gnai1 Gnb5 Cacna2d2 Gng11 Adra2a Gng12 Adra2c Cacnb3 Gng13 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629597 Highly calcium permeable nicotinic acetylcholine receptors Chrna3 Chrnb4 Chrna2 Chrnb3 Chrnb2 Chrna1 Chrna6 Chrna5 Chrna4 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%9637690 Response of Mtb to phagocytosis Nos2 Gsk3a Pgk1 Sfpq Coro1a Ctsg Vps33b Rab5a Rnf213 Hgs Dusp16 Trim27 Ubc Atp6v1h Mapk1 EG433182 Mapk3 Kpna1 Kpnb1 Rab7 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 96%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Slc25a4 Slc25a5 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME DATABASE ID RELEASE 96%5619063 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) Slc29a3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy Atp6v1c1 Atp6v1h Atp6v1a Atp6v1b2 Atp6v0b Atp6v0d1 Atp6v0e1 Asah1 Atp6v1g1 Atp6v1e1 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse Myl6 Rock2 Rock1 Myh14 Rhob Myh10 Sema4d Rnd1 Myh9 Rhoc Arhgef11 Limk1 Plxnb1 Limk2 Rhoa Myl12a Erbb2 Myl12b Myh11 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants Bcr Myo18a Cux1 Fgfr1op2 Stat5a Cpsf6 Cep43 Stat5b Gab2 Zmym2 Pik3ca Stat3 Stat1 Pik3r1 Trim24 IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 96%9732724 IFNG signaling activates MAPKs Jak2 Mapk1 Ifngr2 Jak1 Ifngr1 Mapk3 Ifng Raf1 SOMITOGENESIS%REACTOME DATABASE ID RELEASE 96%9824272 Somitogenesis Lef1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Dll1 Psmb3 Psmb2 Ctnnb1 Notch1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Tbx6 Psmd7 Psmd6 Psmd8 Psmd3 Rbpj Psmd2 Hes7 Psmd1 Epha4 Adrm1 Sem1 Lfng Dll3 Mesp2 Msgn1 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK Pcna Rfc4 Rpa2 Rfc1 Rfc2 Rpa3 Polk Ubc Mad2l2 Rev1 Rev3l Rfc5 Rfc3 Rpa1 RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events Opn1sw Rdh12 Lrat Stra6 Ttr Abca4 Rdh5 Rlbp1 Rbp4 Napepld Opn1mw Rbp1 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 96%198753 ERK MAPK targets Ppp2cb Ppp2ca Dusp3 Dusp4 Mapk7 Dusp7 Dusp6 Mapk11 Mef2a Elk1 Mapk1 Rps6ka5 Mapk3 Ppp2r5d Rps6ka3 Rps6ka1 Mef2c Rps6ka2 Vrk3 Mapk14 Ppp2r1b Ppp2r1a REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 96%2029482 Regulation of actin dynamics for phagocytic cup formation Cd3g Elmo2 Pak1 Vav2 Cyfip1 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Btk Actg1 Actb Myo5a Hsp90ab1 Arpc3 Arpc2 Cyfip2 Arpc5 Arpc4 Limk1 Fcgr1 Fcgr3 Mapk1 Fcgr4 Syk Ptk2 Mapk3 Myh2 Brk1 Myo1c Nckipsd Was Wasf3 Baiap2 Nckap1l Wasl Myo10 Crk Nckap1 Nck1 Wasf2 Wasf1 Abl1 Abi2 Myo9b Abi1 Myh9 Rac1 Vav1 Elmo1 Nf2 Hsp90aa1 Cfl1 Vav3 Dock1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196849 Metabolism of water-soluble vitamins and cofactors Nt5e Cyb5a Slc23a1 Cyb5r3 Slc23a2 Ldlrap1 Amn Lrp2 Bst1 Parp14 Parp16 Tcn2 Cubn Parp4 Parp6 Parp8 Parp10 Parp9 Dhfr Gsto2 Nampt Lmbrd1 Pcx Abcd4 Pcca Mmaa Pccb Mmut Mmab Mmadhc Mmachc Slc5a6 Pdzd11 Aasdhppt Enpp1 Nnmt Enpp2 Prss2 Mtrr Enpp3 Pank3 Pank2 Mtr Pank4 Mccc1 Vnn1 Slc25a16 Vnn3 Gsto1 Abcc1 Mccc2 Ppcs Pank1 Fasn Dcakd Shmt1 Ppcdc Pdxk Slc25a42 Slc52a2 Coasy Naxe Slc52a3 Folr2 Btd Ctrb1 Slc25a51 Cd320 Slc19a1 Slc19a2 Slc5a8 Cblif Mthfr Slc25a32 Thtpa Mthfd1l Naprt Rfk Slc2a3 Acp5 Aox1 Nadk2 Nudt12 Mthfd2l Nmrk2 Slc46a1 Nmrk1 Mocs3 Slc25a19 Mocs2 Aldh1l1 Hlcs Slc2a1 Nadsyn1 Aldh1l2 Shmt2 Cd38 Pnpo Nadk Nmnat1 Flad1 Slc22a13 Nmnat3 Nmnat2 Tpk1 Mthfsl Qprt Mthfd1 Mthfd2 Gphn Acacb Mocos Acaca TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159230 Transport of the SLBP Dependant Mature mRNA Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Eif4e Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Slbp Nup210 Nup155 Nup153 Alyref Nxf1 Nup85 Ncbp2 Ncbp1 Nup37 Sec13 Nup160 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cnot9 Cnot6l Trp53 Cnot8 Npm1 Tnks1bp1 Cnot11 Plk2 Plk3 Rgcc Cnot10 Cpap Cnot3 Btg2 Cnot2 Cnot1 Cnot7 Cdc25c Cnot6 Cnot4 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) Sv2c Sv2b Sv2a Vamp1 Vamp2 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 96%9700206 Signaling by ALK in cancer Mapk9 Mapk8 Tyk2 Stat5a Wdcp Jun Vcl Fn1 Grb2 Stat3 Junb Cltc Stat1 Atic Sqstm1 Skp1 Tfg Gzmb Sec31a Npm1 Rbx1 Lmo7 Rb1 Pik3cb Zap70 Mdm2 Rrbp1 Ubc Pik3ca Gcc2 Mapk1 Cdkn1a Mapk3 Kif5b Ppfibp1 Cul1 Cebpb Frs2 Irs1 Trp53 Ranbp2 Il10ra Plcg1 Frs3 Ptpn6 Irf4 Hdac1 Prf1 Foxm1 Bcl2a1d Msn Zc3hc1 Hip1 Icos Tpr Alk Tnrc6c Eml4 Bcl11a Ppm1b Eef1g Cars1 Prkar1a Eif2ak3 Dctn1 Strn Birc6 Mov10 Ago4 Ago3 Ago2 Ago1 Klc1 Il10 Mcl1 Dnmt1 Rnf213 Twist1 Myh9 Il22b Pik3r1 Pik3r2 Tpm3 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 Stat3 Hgf Met NUCLEOTIDE SALVAGE DEFECTS%REACTOME%R-HSA-9734207.3 Nucleotide salvage defects Aprt Hprt1 Ada ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%1280218 Adaptive Immune System Tlr4 Fkbp1a Nfatc1 Nfatc3 Ppia Nfatc2 Rasgrp3 Rasgrp1 Ppp3r1 Ppp3ca Ppp3cb Blnk Jun Plcg2 Cd79a Cd79b Ap2m1 Btk Prkn Prkacb Ube2l3 Mylip Ap2a2 Ap2a1 Erap1 Itch Rbx1 Stub1 Dapp1 Ap2b1 Fcgr1 Ap2s1 Fcgr4 Syk Was S100a1 Cd36 Tirap Ube2b Inpp5d Colec12 Ahcyl1 Orai1 Orai2 Prkaca Stim1 Kbtbd7 Itpr3 Itpr2 Itpr1 Cul3 Nectin2 Fzr1 Skp2 Mrc1 Ccnd1 Btn1a1 Cdk4 Btnl9 Btn2a2 Cd300a Btnl2 Hspa5 Cdc20 Ppp2cb Ppp2ca Itgb7 Itgb2 Icam5 Icam4 Plcg1 Kif2a Kif2b Kif2c Dync1li2 Dync1li1 Ifi30 Ripk2 Myd88 Dynll1 Dynll2 Icam1 Ppp2r1b Ppp2r1a Kif18a Dync1h1 Dync1i2 Dync1i1 C3 Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Sec13 Vcam1 Cd22 Actr1a Ppp2r5e Dctn2 Dctn3 Cd14 Cenpe Kif3a Kif3b Kif3c H2ac20 H2-Eb1 Sipa1 Trib3 Rap1gap2 Prkaa1 Prkaa2 Myc Akt3 Akt2 Akt1 Erlin2 Cd74 Erlin1 Ctse Atf3 Ctsf Actr1b Jund Rpn2 Ctsh Rpn1 Kif26a Hif1a Ctso Tcf7l1 Kif11 Tcf7l2 Kif15 Lyn Lag3 H2-DMa Mov10 H2-Ob Yes1 H2ac12 Kif22 H2ac11 Kif23 Ago4 H2-Oa Cxadr Ago3 Rilp Ago2 Kif20a Ago1 Jaml Osbpl1a H2ac15 Klc1 Klc4 H3c7 Ezh2 Klc3 Klc2 H2ax Sell H2-DMb2 B3gnt3 Csnk2a2 Tead4 Suz12 Cd28 Nfkb2 Ash2l Rac1 Hist1h2bp Jak1 Fos Trem1 Vav1 H2aj Os9 Pik3r5 Pik3r6 Kifap3 Pik3r1 Pik3r2 Yap1 Tnfrsf14 Ctla4 Cd3g Cd3e Cd3d Pak1 Sel1l Fosb Magt1 Pak3 Pak2 Brd4 H2bc9 H2bc7 H2bc8 Grap2 H2bc3 Cd300lb Mib2 Cd300lg Tead3 Cd300lf Tead2 S100a9 Cd226 Trat1 Tead1 S100a8 Npdc1 Pik3ap1 Stat3 Cd40lg Tmem258 Mill2 Hcst Stat1 Map3k14 Klrk1 Rictor Klrg1 Siglec1 H2ab2 Map3k8 Klrc1 Rnf185 Clec4g Lair1 Mycn Ncr1 Derl3 Nek2 Pianp Klrb1 Derl2 Lilra5 Derl1 H2bu2 Cd300e Cd86 Cd1d2 Cd80 Cd96 Treml2 Stt3a Stt3b Sh2d1a Spop Treml4 Treml1 Vcp Cd300c2 Tcf7 Klrd1 Ostc Siglec12 Prkag3 Cd200 Pik3cg Cd160 Pik3cb Crtam Pik3cd Prkag1 Oscar Cd200r1 Prkag2 Cops5 Fcgr2b Slamf6 Pik3ca Sh2d1b1 Wwtr1 Tusc3 Cd8a Slamf7 Kmt2c Wwp1 Btla Pilra Hist2h2aa1 Pilrb Siglecg Erlec1 Prr5 Dad1 Socs3 Ywhag Kif5b Pdpk1 Epas1 Pag1 Dpy30 Wdr5 Ddost Csnk2b Eed Them4 Cd274 Gsk3b Lck Irf1 Mlst8 Icosl Lef1 H2bc14 Ptpn6 Pdcd1 Rnf5 Mtor Cd4 Ptpn11 Fyn Csk Cd209a H2bc21 Itga4 Tnrc6c H2bc26 Rbbp5 Icam2 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Pdcd1lg2 Mapkap1 Rab7 Prkab2 Prkab1 Itgal Vamp3 Itgb1 Rnf34 Mrc2 Sec61a2 Sec61a1 Tap2 Tap1 Eloc Cd207 Stx4 Tapbp Sec61b Capzb Itgb5 Capza1 Capza2 Rnf111 Ctsd Fbxw10 Fbxw4 Fbxw5 Fbxw7 Fbxw9 Fbxw2 Fbxo4 Ube2d3 Itgav Fbxo6 Nedd4l Fbxo32 Dnm1 Kif4 Dnm3 Vasp Fbxl3 Fbxl5 Cul2 Nck1 Trim63 Sptbn2 Evl Ctsa Clta Cltc Calr Arf1 Canx Vamp8 Blk Zap70 Dnm2 Itk Fyb1 Cd101 Lcp2 Lat Pik3c3 Pik3r4 Pten Lrr1 Nedd4 Rnf220 Fbxl20 Rnf213 Wsb1 Rnf217 Hecw2 Ccnf Cblb Ctsb Sh3rf1 Ctss Trim11 Ube2l6 Lgmn Mex3c Rnf126 Cd81 Dcaf1 Rapgef4 Rnf123 Rapgef3 Ubac1 Lnpep Atg7 Rnf114 Cd19 Rnf115 Hace1 Siah2 Trpc1 Keap1 Kbtbd13 Dzip3 Mkrn1 Ube2g2 Ube2g1 Rnf138 Rnf130 Kbtbd8 Ctsk Ctsl Gan Fbxw8 Anapc13 Det1 Klhl9 Psma4 Rbck1 Ikbkb Arih2 Psma3 Rlim Psma6 Klhl2 Psma5 Ube4a Psma2 Spsb2 Psma1 Trim9 Ikbkg Spsb1 Ctsc Trip12 Map3k7 Spsb4 Psmd12 Psmd11 Lrsam1 Psmd14 Huwe1 Ube2j2 Psmd13 Nfkb1 Ube2j1 Smurf2 Sec22b Socs1 Skp1 Smurf1 Malt1 Kctd7 Psmb5 Ube2w Psmb4 Ap1m2 Ube2m Psmb7 Ap1m1 Ube2k Psmb6 Rnf182 Psmb1 Ap1s3 Ube2o Psmb3 Ap1s2 Ltn1 Psmb2 Ap1b1 Ube2h Ap1s1 Mgrn1 Fbxw11 Ap1g1 Ube2f Rela Sec31a B2m Card11 Ube2a Prkcb Fbxo10 H2-Q10 Btrc Fbxo11 Psma7 Ptprj Fbxo17 Psmc6 Lmo7 Psmc5 Rnf41 Psmc2 Ube3d Psme2 Psmc1 Ube3c Psme1 Psmc4 Lrrc41 Psmc3 Klhl13 Kctd6 Ube2z Ubc Psmb10 Bcl10 Klhl11 Psmd7 Ube3b Psmd6 Ube3a Nfkbib Traip Ppl Nfkbie Fbxo21 Psmd8 Ubox5 Becn1 Psmd3 Fbxo22 Psmb9 Psmd2 Ubr1 Psmb8 Psmd1 Rnf19a Nfkbia Ubr2 Glmn Adrm1 Ubr4 Sem1 Cul1 Traf6 Fbxo27 Rel Ube2v2 Ube2n Prkcq Chuk Uba5 Uba6 Rasgrp2 Uba7 Cdc34 Trim69 Ube2v1 Trim71 Klhl25 Ube2e3 Tab2 Ube2e2 Btbd6 Rnf19b Klhl21 Klhl22 Klhl20 Fbxl8 Fbxo30 Fbxo31 Fbxl4 Fbxl7 Lonrf1 Zbtb16 Uba1 Uba3 Tpp2 Cul5 Actr10 Cul7 Dctn5 Fbxo41 Dctn6 Dctn1 Traf7 Dctn4 Hectd1 Capza3 Fbxo44 Hectd2 Hectd3 Thop1 Znrf1 Ywhaz Trim50 Dtx3l Rap1gap Blmh Rnf14 Tyrobp Klhl41 Klhl42 Ptprc Ufl1 Fbxo40 Npepps Ube2q2 Ube2q1 Trem2 Btbd1 Pja2 Pja1 Arel1 Rnf144b Fbxo2 Asb12 Asb11 Siah1a Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Herc4 Herc2 Herc3 Ube2r2 Herc1 Rnf6 Rnf7 Rnf4 Fbxo7 Herc6 Fgb Fbxo9 Fga Rap1b Trim21 Vhl Fbxl12 Fbxl13 Fbxl14 Fgg Fbxl15 Fbxl16 Trim39 Fbxl18 Raf1 Fbxl19 Trim37 Xdh Trim36 Trim32 Anapc5 Trim41 Anapc4 Asb9 Anapc1 Asb8 Anapc2 Asb7 Anapc11 Asb6 Tlr1 Ube2c Asb5 Anapc10 Rnf25 Tlr6 Tlr2 Anapc7 Asb4 Asb3 Cdc27 Asb2 Rchy1 Ube2d1 Cdc16 Asb1 Lnx1 Ube2e1 Cdc23 Sh3kbp1 Ctnnb1 Cdh1 Sh3gl2 Ywhab Ncf1 Ncf2 Rap1a Ncf4 Nras Sos1 Hras H2-M5 H2-M3 Ptpn22 Racgap1 Snap23 Cyba Ep300 Cybb H2-Q1 Sar1b Sec23a Pdia3 Cd8b1 Nfe2l2 Sec24d Ly96 Sec24c Crebbp Sec24b Sec24a EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Cdkn2a Cdk6 Cdk4 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs Alox12 Alox5 Ptgs2 Alox15 PHOSPHO-PLA2 PATHWAY%REACTOME%R-HSA-111995.3 phospho-PLA2 pathway Pla2g4a Mapk1 DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME%R-HSA-3656234.4 Defective HEXA causes GM2-gangliosidosis 1 Hexa SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants Pdgfra TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P Taldo1 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373076 Class A 1 (Rhodopsin-like receptors) Adora2b Anxa1 C3ar1 App S1pr1 Npy Cxcr4 Cxcl12 Cysltr2 Ednra Cysltr1 Npff Trhr Gnrh1 Nmbr Fpr2 Ptgfr Agtr1a Nmb Lpar6 Xcr1 Lpar5 Ppan Grpr Gpr17 Nms Nmu Cckar Nmur2 Gnrhr Nmur1 Ntsr2 Ntsr1 Brs3 Ptger1 Gpr132 Edn2 Cckbr F2 Hcrt Grp Kiss1r Nps Ptafr Npffr1 Npffr2 Prok2 Gpr4 Qrfp Prok1 Npsr1 Agt P2ry10 F2rl1 F2rl2 F2rl3 Prokr2 Ghsr Prokr1 Gpr65 Gpr68 Uts2 Tacr1 Tacr3 Tacr2 Ccl12 F2r Ffar3 Ffar4 Bdkrb2 Ffar1 Bdkrb1 Ffar2 Nts Kng2 Tac3 Tac1 Opn4 Pmch Ltb4r1 Ltb4r2 Trh Lpar4 Lpar3 Lpar2 Lpar1 Qrfpr Xcl1 Kiss1 P2ry6 P2ry2 P2ry1 Hcrtr2 Hcrtr1 Uts2b Cck Uts2r Adra2a Adra2c Adra2b Rho Saa3 Sst C5ar2 C5ar1 C3 C5 Avpr2 Sstr3 Oxtr Avpr1b Avpr1a Oxt Avp Oprm1 Ednrb Edn1 Edn3 Mc1r Mchr1 Mc5r Adora2a Pdyn Galr2 Galr3 Rxfp3 Galr1 Rln3 Rxfp2 Fpr1 Rxfp1 Mc4r Rln1 Pomc Insl3 Rxfp4 Pnoc Insl5 Gpr18 Gpbar1 Fpr-s1 Mc3r Ptger4 Ccr5 Ptger2 Ptger3 Mtnr1a Mtnr1b Agtr2 Gpha2 Gpr37 Gpr35 Gpr31 Oprk1 Cga Rgr Ccl17 Ccl11 Tshb Ptgdr2 Cx3cl1 Ccl28 Ccl25 P2ry13 Ccl22 P2ry12 Ccl20 Gpr55 P2ry14 Lhcgr Oxgr1 Sucnr1 Prlhr Ece1 Psap Ccl7 P2ry4 Ccl5 Adra1b Ccl4 Adra1a Ccl3 Adra1d Ccl2 Ccl1 Mrgprd Rrh Ptgdr Tbxa2r Apln Oprd1 Cmklr1 Sstr5 Sstr4 Kel Sstr2 Sstr1 Gpr183 Lhb Ppbp Ccr10 Nln Cx3cr1 Ppy Ccr1 Npbwr1 Fshb Mc2r Fshr Ccr9 Pf4 Ccr8 Ccr7 Ccr6 Ccr4 Ccr3 Ccr2 Plppr1 Gal Plppr4 Plppr5 Gpr143 Htr4 Plppr2 Plppr3 Chrm1 Penk Hrh1 Npb Chrm3 Htr6 Opn1mw Npw Chrm2 Htr7 Mas1 Chrm5 Hrh4 Hcar1 Chrm4 Hcar2 Hrh2 Cxcr1 Hrh3 Cxcr2 Htr2a Npy1r Htr2c Cxcr3 Htr2b Xk Drd1 Cxcr5 Adrb2 Cxcr6 Drd2 Oprl1 Adrb1 Prlh Drd3 Cxcl11 Drd4 Hebp1 Drd5 Adrb3 Cxcl10 Aplnr Opn1sw Taar8b Opn3 Htr1d Taar6 Ccrl2 Gper1 Htr1f Taar9 Opn5 Taar2 Pyy Taar5 Adora1 Adora3 Htr1b Cxcl16 Htr1a Taar1 Cxcl13 Htr5a Npy5r Npy4r Ptgir Tshr Cxcl9 S1pr3 Cxcl1 S1pr2 S1pr5 Cxcl2 S1pr4 Cxcl3 Cxcl5 Gpr37l1 Npy2r Ackr3 Ackr4 Cnr1 Ackr1 Ackr2 Cnr2 Cort ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes Atp6v1a Atp6v1b2 Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Rac2 Atp6v1h Nos3 Cyba Cybb Nos2 Atp6v0b Atp6v0a2 Atp6v0a4 Atp6v1g3 Lpo Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Mpo Nos1 Slc11a1 Ncf1 Ncf2 Hvcn1 Ncf4 Atp6v1e2 Atp6v1e1 Tcirg1 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9754678.3 SARS-CoV-2 modulates host translation machinery Rps5 Rps25 Rps26 Rps21 Rps15a Rps27l Rps27 Gemin7 Gemin4 Rps3 Gemin5 Rps4x Snrpb Smn1 Snrpd2 Snrpd1 Rps14 Snrpd3 Gemin2 Rps16 Ddx20 Rps18 Rps19 Rpsa Rps10 Rps11 Rps9 Rps7 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME%R-HSA-9931512.1 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters Clock Bmal1 Crebbp EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%3928664 Ephrin signaling Ephb4 Ephb6 Git1 Efnb1 Efnb2 Pak1 Efnb3 Pak3 Ephb2 Pak2 Nck2 Fyn Rac1 Arhgef7 Sdcbp Ephb1 Ephb3 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation Prelp Galns Lum Hexa Kera Hexb Omd Ogn Glb1 Fmod Gns Glb1l3 Glb1l2 MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 96%9022927 MECP2 regulates transcription of genes involved in GABA signaling Gad1 Gad2 DEFECTIVE CUBN CAUSES MGA1%REACTOME DATABASE ID RELEASE 96%3359463 Defective CUBN causes MGA1 Amn Cblif Cubn TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-HSA-8878159.4 Transcriptional regulation by RUNX3 Tgfb1 Psma4 Psma3 Psma6 Psma5 Tead3 Psma2 Tead2 Psma1 Cdkn2a Tead1 Bcl2l11 Psmd12 Psmd11 Psmd14 Psmd13 Smurf2 Spp1 Smurf1 Foxo3 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Runx3 Psmb3 Brd2 Psmb2 Src Mamld1 Ctnnb1 Notch1 Tcf7 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Cbfb Ccnd1 Psmc4 Psmc3 Mdm2 Ubc Kat2b Psmd7 Wwtr1 Psmd6 Kat2a Cdkn1a Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Zfhx3 Trp53 Smad3 Lef1 Smad4 Hdac4 Myc Itga4 Hes1 Tcf7l1 Jag1 Ep300 Tcf7l2 Itgal Tead4 Kras Maml1 Maml2 Ccn2 Rbpj Crebbp Yap1 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190239 FGFR3 ligand binding and activation Fgf16 Fgf23 Fgf18 Fgf2 Fgf1 Fgf4 Galnt3 Fgf9 Fgf20 ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism Ltc4s Ggt1 Alox12 Cyp2u1 Hpgd Cyp1b1 Lta4h Cyp4a32 Cyp4f15 Dpep1 Dpep2 Cyp2c65 Cyp2j6 Ggt5 Cyp1a1 Cyp2c50 Ptgis Cyp1a2 Tbxas1 Cyp8b1 Alox5ap Alox15 Cyp4f39 Cyp4f17 Abcc1 Slc27a1 Cyp4a12b Cyp4f3 Mapkapk2 Cyp4f40 Cyp4b1 Ptgr1 Alox8 Ptgr2 Ptgs1 Ptgds Awat1 Aloxe3 Gpx4 Alox12b Ptges Faah Prxl2b Cbr1 Akr1c18 Pla2g4a Hpgds Ephx2 Pon3 Pon1 Pon2 Gpx2 Alox5 Ptgs2 Ptges2 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%1250196 SHC1 events in ERBB2 signaling Nrg3 Prkcd Nras Nrg1 Prkca Ptpn12 Sos1 Hras Egfr Erbb2 Egf Shc1 Ereg Hbegf Btc Nrg2 Prkce Nrg4 MAPLE SYRUP URINE DISEASE%REACTOME%R-HSA-9865114.1 Maple Syrup Urine Disease Bckdhb Bckdha Dbt Dld Ppm1k PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 96%141334 PAOs oxidise polyamines to amines Paox DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 96%5579014 Defective CYP27B1 causes VDDR1A Cyp27b1 SIGNALING BY EGFRVIII IN CANCER%REACTOME DATABASE ID RELEASE 96%5637812 Signaling by EGFRvIII in Cancer Cdc37 Nras Gab1 Plcg1 Cbl Sos1 Hras Egfr Pik3ca Egf Shc1 Hsp90aa1 Pik3r1 MRNA CAPPING%REACTOME%R-HSA-72086.5 mRNA Capping Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Rnmt Ercc3 Cdk7 Rngtt Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters Slc39a8 Slc11a2 Slc41a2 Slc39a7 Slc30a5 Slc41a1 Slc39a6 Slc39a5 Slc30a3 Slc30a2 Slc30a8 Slc24a5 Slc30a1 Slc24a4 Heph Slc30a10 Slc24a1 Slc9a4 Slc9a5 Slc9a2 Slc9a3 Slc9a8 Slc39a14 Slc9a9 Slc9a6 Slc39a10 Slc9a7 Slc9a1 Slc40a1 Sri Cp Slc8a1 Slc8a2 Slc11a1 Slc8a3 Slc39a3 Slc24a3 Slc31a1 Slc8b1 Slc24a2 Slc39a4 Slc39a2 Slc39a1 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%210990 PECAM1 interactions Yes1 Fyn Itgav Lck Inpp5d Pecam1 Plcg1 Ptpn6 Itgb3 Lyn Ptpn11 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter Polr3gl Crcp Polr3a Polr3d Brf1 Polr3e Polr1c Polr3b Polr3c Polr3h Polr3f Polr1d Polr3g Polr3k Gtf3c2 Gtf3c1 Gtf3c4 Gtf3c3 Gtf3c6 Gtf3c5 Bdp1 Tbp Polr2h Polr2e Polr2f Polr2k G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK Gngt1 Gngt2 Gng10 Gng3 Gng2 Gnb2 Gnb1 Gng4 Btk Gnb4 Gnb3 Gng7 Gnb5 Gng11 Gng8 Gng12 Gng13 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020591 Interleukin-12 signaling Pdcd4 Pitpna Jak2 Il12rb1 Il12rb2 Ppia Rap1b Il12b Capza1 Il12a Cnn2 Pak2 Ifng Tyk2 Hspa9 Msn Hnrnpf Sod2 Lmnb1 Arf1 Tcp1 Vamp7 Il10 Psme2 Ca1 Taldo1 Snrpa1 Jak1 Anxa2 Bola2 Stat4 Gsto1 Hnrnpa2b1 Serpinb2 Aip Mtap Cfl1 Mif Hnrnpdl P4hb Rala Lcp1 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters Slc13a4 Slc13a1 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 96%9837999 Mitochondrial protein degradation Prkaca Acad8 Ndufv1 Ndufv3 Acadsb Ndufs1 Me2 Ndufa2 mt-Co2 Hadh Uqcrq Idh3a Ndufb6 Aldh1b1 Uqcrc2 Pccb Aldh2 Oxsm Aldh18a1 Cox5a Clpp Clpx Glud1 Mrpl32 Lonp1 Star Afg3l2 Htra2 Bdh1 Smdt1 Oxct1 Mdh2 Hmgcs2 Acat1 Yme1l1 Spg7 Micu2 Mrps10 Pmpca Ogdh Twnk Mrps2 ATP6 Ssbp1 Atp5f1c Atp5pf mt-Nd5 mt-Nd6 Fech mt-Nd1 mt-Nd2 Alas1 Hspa9 Suclg2 Atp5f1b Ech1 Atp5f1a mt-Co1 Acot2 Timm9 Tfam Cox4i1 Nadk2 Hspd1 Triap1 Oma1 Aco2 Opa1 Prelid1 Timm10 Slc25a5 Shmt2 Cs Ndufa13 Hsd17b10 Dbt Dld Fh Timm22 Eci1 Arg2 Ldhd Stard7 Pdha1 Mrpl12 Pdk1 Idh2 Iars2 Pdhb SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 96%198765 Signalling to ERK5 Map2k5 Mapk7 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle Sun2 Golga2 Chmp2a Ywhae Chmp3 Cdc25c Chmp7 Chmp6 Lmnb1 Cdc25b Cdc25a Chmp4c Rbx1 Chmp4b Top2a Prkar2b Lig1 Prdm9 Nek9 Nek6 Nek7 Prkaca Tinf2 Ppp1r12a Cdkn2a Cdkn2b Cdkn2c H3c8 Ccne1 Ccne2 Acd Atrx Fzr1 Tfdp2 Tfdp1 Skp2 Rb1 Ccnd2 Terf2ip Ccnd3 Ccnd1 Cdk6 Cdk4 Mdm2 Cdk2 Mdm4 E2f1 E2f2 Ccna1 E2f3 Ccna2 Terf2 Cdkn1a Daxx Terf1 Cdkn1b Cdkn1c Clasp1 Clasp2 Pafah1b1 Smc3 Pot1 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Rad21 Kif2b Kif2c Dync1li2 Pmf1 Wapl Syce2 Ska1 Syce3 Dync1li1 Syce1 Ahctf1 Sun1 Tex12 Nup107 Sycp1 Dsn1 Mapre1 Sycp2 Syne1 Zwint Syne2 Dynll1 Sycp3 Dynll2 Rps27 Stag3 Rec8 Rcc2 Smc1b Kntc1 Stag2 Stag1 Ppp2r1b Ppp2r1a Pds5b Pds5a Ndc80 Kif18a Nudc Hmmr Dync1h1 Birc5 Spc24 Spc25 Ercc6l Nuf2 Ccnb2 Nup85 Cdca8 Incenp Cdca5 Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Akap9 Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Hspa2 Bub3 Bub1 Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Nedd1 Cenps Cenpq Actr1a Cenpp Ppp2r5e Cenpo Cenpn Cenpm Spast Dctn2 Espl1 Mis12 Dctn3 Lemd2 Nup133 Cenpl Cc2d1b Ist1 Zwilch Cenpk Vrk1 Cenpi Sirt2 Cenph Phf20 Smc1a Cenpf Pcbp4 Cenpe Chek2 Optn Zfp385a Cop1 Mlh1 Pcnt Cep250 Sdccag8 Cep78 Cep76 Cep72 Polr2c Cep70 Polr2d Polr2a Polr2b Tubb5 Polr2g Plk4 Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Cep135 Cep131 Ccnh Cdk7 Prkca Haus7 Haus8 H2ac20 Tert Cdk5rap2 Myc Akt3 Akt2 Akt1 Eml4 Cep57 Tyms Dhfr Pcm1 Tk1 Dyrk1a Fkbp6 Ssna1 Tubg1 Lyn Ofd1 Pttg1 H2ac12 H2ac11 Kif23 Kif20a H2ac15 Cep63 H3c7 Cep152 Haus3 H2ax Csnk2a2 Haus4 Haus5 Rcc1 Haus6 Sfi1 Csnk1d Haus1 Vps4a Hist1h2bp Haus2 H2aj Cep164 Ccp110 Alms1 Smc4 Smc2 Cetn2 Tubgcp2 Tnpo1 Numa1 Ncaph Rab8a Tubg2 Ncapd2 Nme7 H2bc9 Tubgcp5 H2bc7 Plk3 Tubgcp4 H2bc8 Cdc7 Cep43 Tubgcp3 Mzt1 H2bc3 Mzt2 Cep41 Ninl H2ab2 Nek2 Pkmyt1 H2bu2 Hist2h2aa1 Ywhag Csnk2b Gsk3b Csnk1e Csnk1a1 Nek11 H2bc14 H2bc21 H2bc26 Rbbp4 Abl1 Rbbp7 Lcmt1 Obi1 Bora Ppme1 Ticrr Cdk11b Ajuba Emd Lemd3 Lbr Tuba1b Tuba1a Fbxo5 Tpx2 Tuba1c Ankle2 Tubal3 Tubb2b Ppp1cb Tubb2a Lpin3 Lpin2 Lpin1 Tuba4a Tuba8 Ppp2r2a Tuba3b Wrap53 Tubb6 Tubb3 Trp53 Tubb1 Tubb4b Tubb4a Nup93 Nup50 Nup35 Mybl2 Nup54 Pom121 Nup205 Nup188 Rbl2 Tpr Rae1 Ndc1 Nup42 Nup62 Rbl1 Nup88 Aurka Aaas Nup214 Banf1 Nup210 Nup155 Cdc14a Nup153 Mdc1 Orc5 Orc4 Orc6 Orc1 Mcm8 Orc3 Orc2 Sfn Kpnb1 Hsp90aa1 Dkc1 Nhp2 Gar1 Nop10 Ruvbl1 Psmc3ip Mnd1 Mlh3 Spo11 Msh4 Dmc1 Msh5 Ran Kmt5a Max Cdt1 Cpap Gmnn Fen1 Dbf4 Mcm10 Clspn Trp53bp1 Abraxas1 Brcc3 Rnf168 Nsd2 Babam1 Babam2 Uimc1 E2f4 E2f5 E2f6 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Ppp6r3 Psmd14 Psmd13 Skp1 Psmb5 Nipbl Psmb4 Psmb7 Ensa Ppp6c Psmb6 Rab2a Psmb1 Ctdnep1 Psmb3 Cnep1r1 Psmb2 Blzf1 Fbxw11 Ppp2r2d Ncaph2 Arpp19 Npm1 Prkcb Ncapd3 Btrc Ncapg2 Psma7 Mau2 Psmc6 Gorasp2 Psmc5 Rab1a Mastl Psmc2 Mcph1 Psmc1 Rab1b Psmc4 Psmc3 Ubc Psmd7 Uso1 Psmd6 Fkbpl Gtse1 Phlda1 Psmd8 Psmd3 Psmd2 Psmd1 Rsf1 Oip5 Adrm1 Mis18a Gorasp1 Sem1 Cenpx Cul1 Cenpw Ube2v2 Ube2n Mis18bp1 Ankrd28 Pias4 Ywhah Hdac1 Fbxl7 Ube2i Kat5 Exo1 Nbn Rfc5 Pold2 Pold1 Ywhaz Rfc3 Pcna Rfc4 Fignl1 Rfc1 Rfc2 Pold4 Pold3 Hus1 Atrip Brip1 Dna2 Pole3 Rad51c Pole2 Blm Chek1 Pole4 Rrm2 Rad9a Bard1 Rad9b Top3a Wrn Mre11a Herc2 Rad51 Rad50 Firrm Rpa1 Topbp1 Jak2 Rpa2 Rad17 Rbbp8 Rtel1 Brca2 Brca1 Rpa3 Rad1 Fbxl18 Atm Pole Plk1 Anapc5 Anapc4 Shq1 Anapc1 Dscc1 Anapc2 Anapc11 Ruvbl2 Pif1 Ube2c Anapc10 Chtf18 Ctc1 Anapc7 Cdk1 Chtf8 Cdc27 Stn1 Ube2d1 Ten1 Cdc16 Anapc16 Ube2e1 Hsp90ab1 Cdc23 Anapc15 Gins2 Gins1 Mcm7 Gins4 Gins3 Mcm3 Mcm4 Ptk6 Mcm5 Cks1b Cables1 Mcm6 Lin54 Cdc45 Mapk1 Esco1 Mcm2 Esco2 Lin9 Ywhab Wee1 Lin37 Mapk14 Mapk11 Foxm1 Cdc6 Ep300 Prim2 Prim1 Pola2 Pola1 Smarca5 Xpo1 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) Slc2a2 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 96%162599 Late Phase of HIV Life Cycle Taf4 Taf3 Taf2 Taf1 Ppia Nup133 Chmp2a Chmp3 Chmp7 Chmp6 Chmp4c Chmp4b Ubc Polr2c Pdcd6ip Polr2d Polr2a Polr2b Polr2g Nedd4l Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Nmt2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Rnmt Ercc3 Cdk7 Rngtt Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Ubap1 Tsg101 Mvb12a Mvb12b Vps37a Vps37b Vps37c Rcc1 Vta1 Vps37d Ranbp1 Nmt1 Chmp5 Vps28 Vps4a Vps4b Ran Furin Nup37 Nup160 Nup43 Ranbp2 Nup107 Ell Nelfa Nelfb Nelfe Taf15 Ctdp1 Taf11 Taf13 Taf12 Ccnk Tbp Taf4b Xpo1 Gtf2a1 Gtf2a2 Gtf2b Nup85 Gtf2e1 Gtf2e2 Taf9 Ncbp2 Ncbp1 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Taf8 Eloa Sec13 Taf7 Taf6 Eloc Taf5 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855170 IPs transport between nucleus and cytosol Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Nup85 Nup37 Sec13 Nup160 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 96%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA Dhtkd1 Dlst Dld CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69273 Cyclin A B1 B2 associated events during G2 M transition Ppp2cb Ppp2ca Ccnh Sgo1 Cdk7 Foxm1 Plk1 Lcmt1 Cdk1 Obi1 Bora Cdc25c Ppme1 Pkmyt1 Ticrr Ppp2r1b Cdc25b Ppp2r1a Cdc25a Fzr1 Xpo1 Ccnb2 Cdk2 Ccna1 Ccna2 Ppp2r2a Wee1 Mnat1 Mis18bp1 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013425 RHOT1 GTPase cycle Rhot1 Rap1gds1 Trak2 Trak1 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation Scg3 Scg2 Meltf Qsox1 Mxra8 Fam20a Apoe Fam20c Fuca2 Stc2 Serpina10 Hrc Ambn Mepe Mia3 Aplp2 App Enam Ktn1 Bmp15 Bpifb2 Fn1 Matn3 Rcn1 Lamb2 Vwa1 Timp1 Fstl3 Prss23 Tmem132a Afp Igfbp5 Lamc1 Igfbp4 Lamb1 Golm1 Amtn Serpind1 Nucb1 Sparcl1 Msln Itih2 Vgf Notum Apoa2 Ltbp1 F5 Apoa5 Fstl1 Pnpla2 Alb Serpina1d Pcsk9 P4hb Cdh2 Mgat4a Prkcsh Sdc2 Pdia6 Ckap4 Csf1 Igfbp3 Bmp4 Wfs1 Igfbp1 Fga Fgg Kng2 Dnajc3 Gpc3 Vcan Spp1 Proc Il6 Serpinc1 Mfge8 Cp Cst3 Tf Gas6 Igfbp7 Tnc Penk Men1 Fbn1 Fgf23 Adam10 Calu Ahsg Spp2 Hsp90b1 C3 C4a Chgb Eva1a Dmp1 Mbtps1 Ccn1 Shisa5 Apoa1 Amelx Lgals1 Apob Ano8 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism Ltc4s Elovl6 Acadvl Ggt1 Cyp2u1 Alox12 Cyp1b1 Cyp4a32 Cyp4f15 Dpep1 Dpep2 Ggt5 Elovl3 Elovl5 Acsl1 Thrsp Slc22a5 Slc27a1 Phyh Amacr Mcat Acad11 Acad10 Hacl1 Alox8 Ptgr2 Crot Slc25a20 Scp2 Acot3 Acot9 Crat Acot7 Ptgs1 Acox2 Rxra Nudt19 Prkaa2 Acot2 Ptgds Acox3 Awat1 Aloxe3 Gpx4 Alox12b Them5 Cpt1b Ptges Mid1ip1 Faah Prxl2b Acot11 Acot12 Hao2 Acot13 Cbr1 Nudt7 Pecr Acaa2 Acbd6 Hpgds Acbd7 Ephx2 Pctp Acsf2 Hadha Hadhb Dbi Cpt2 Acadl Pon3 Pon1 Pon2 Fads2 Fads1 Slc25a17 Acbd4 Hpgd Lta4h Echs1 Acsm3 Acads Hadh Ndufab1 Mcee Cyp2c65 Pcca Mmaa Pccb Cyp2j6 Mmut Cyp1a1 Cyp2c50 Cyp1a2 Ppard Ptgis Tbxas1 Acot8 Hsd17b4 Cyp8b1 Ehhadh Acaa1a Slc27a2 Abcd1 Decr2 Acot4 Prkag2 Alox5ap Alox15 Cyp4f39 Cyp4f17 Abcc1 Cyp4a12b Fasn Cyp4f3 Mapkapk2 Cyp4f40 Cyp4b1 Ptgr1 Them4 Olah Hsd17b8 Acbd5 Hsd17b3 Acly Elovl4 Hacd1 Morc2a Hsd17b12 Acoxl Elovl1 Hacd2 Hacd3 Prkab2 Elovl7 Hacd4 Cbr4 Tecrl Tecr Akr1c18 Pla2g4a Acsbg1 Acsbg2 Acsl5 Ppt2 Acsl6 Scd1 Acsl3 Slc27a3 Ppt1 Acsl4 Mecr Eci1 Acsf3 Gpx2 Acadm Decr1 Acaca Alox5 Ptgs2 Cpt1a Ptges2 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702620 quizartinib-resistant FLT3 mutants Flt3 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME%R-HSA-3560783.4 Defective B4GALT7 causes EDS, progeroid type B4galt7 Sdc1 Gpc1 Ncan Bgn Cspg5 Gpc3 Cspg4 Gpc2 Agrn Dcn Hspg2 Bcan Gpc5 Sdc4 Vcan Sdc3 Gpc4 Sdc2 Gpc6 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-HSA-176408.6 Regulation of APC C activators between G1 S and early anaphase Fbxo5 Psma4 Psma3 Psma6 Psma5 Plk1 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdk1 Cdc27 Skp1 Ube2d1 Psmb5 Cdc16 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Psmb2 Fzr1 Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Cdk2 Ccna1 Psmd7 Ccna2 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Cdc20 Mad2l1 Bub1b Bub3 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 96%445989 TAK1-dependent IKK and NF-kappa-B activation Ube2v1 Trp53 Tab3 Tab2 Tab1 App Ikbkb Ripk2 Ikbkg Map3k7 Traf2 Nkiras1 Nkiras2 Nfkb1 Lrrc14 Ikbip Saa3 Nod2 Rela Nod1 S100b N4bp1 Casp8 Tifa Irak2 Alpk1 Ager Ubc Nlrx1 Nfkb2 Usp14 Usp18 Nfkbib Irak1 Nfkbia Traf6 Ube2n Chuk LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 96%8964572 Lipid particle organization Fitm2 Fitm1 Hilpda Cidec Cidea Hsd17b13 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 96%399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity Cacng8 Cacng4 Cacng2 Gria2 Cacng3 Dlg1 Grip2 Dlg4 Nsf Prkca Gria4 Gria3 Prkcg Akap5 Gria1 Myo6 Pick1 Ap2a1 Prkcb Tspan7 Camk2g Camk2d Mdm2 Camk2b Grip1 Camk2a REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression Nr3c1 Ago4 Ago3 Ago2 Ago1 Kcnip3 Rest Tnrc6c Tnrc6a Tnrc6b Npas4 Srf Mov10 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 96%5676934 Protein repair Msra Pcmt1 Msrb1 Msrb3 Msrb2 Txn G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint Topbp1 Rpa2 Rad17 Rbbp8 Brca1 H2bc9 Rpa3 H2bc7 H2bc8 Rad1 Atm H2bc3 Ywhae Chek2 H3c8 Cdk1 Cdc25c H2bu2 Ccna1 Ccna2 Ywhab Wee1 Ywhag Ube2n Ube2v2 Trp53 H2bc14 Ywhah Pias4 H2bc21 H2bc26 Kat5 Exo1 Trp53bp1 Abraxas1 Nbn Brcc3 Rfc5 Rnf168 Nsd2 Ywhaz Rfc3 Babam1 Babam2 Rfc4 Uimc1 Mdc1 Rfc2 Hus1 Atrip Brip1 H2ax Dna2 Blm Chek1 Hist1h2bp Rad9a Bard1 Rad9b Sfn Top3a Wrn Mre11a Herc2 Rad50 Rpa1 DEFECTIVE CBLIF CAUSES IFD%REACTOME DATABASE ID RELEASE 96%3359457 Defective CBLIF causes IFD Cblif REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate Pcna Rpa2 Prim2 Prim1 Pola2 Pold4 Pola1 Pold3 Rpa3 Dna2 Fen1 Pold2 Pold1 Rpa1 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%9623433 LXRs regulate gene expression to control bile acid homeostasis Ncor2 Nr1h2 Ncor1 Nr1h3 Ncoa1 Rxrb Ugt1a2 Rxra Fabp6 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380259 Loss of Nlp from mitotic centrosomes Prkaca Ccp110 Alms1 Cetn2 Nedd1 Actr1a Tuba1a Cep43 Dctn2 Cep41 Dctn3 Plk1 Ninl Ywhae Cdk1 Nek2 Pcnt Tuba4a Cep250 Sdccag8 Cep78 Cep76 Cep72 Cep70 Tubb5 Plk4 Cpap Clasp1 Ywhag Pafah1b1 Cep135 Cep131 Prkar2b Csnk1e Tubb4b Haus7 Tubb4a Haus8 Cdk5rap2 Cep57 Pcm1 Mapre1 Dynll1 Ssna1 Tubg1 Ppp2r1a Ofd1 Dync1h1 Cep63 Cep152 Haus3 Haus4 Haus5 Haus6 Sfi1 Dync1i2 Csnk1d Haus1 Ckap5 Haus2 Akap9 Hsp90aa1 Cep164 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 96%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Tfap2b Erbb2 Vegfa Tgfa Atad2 Esr1 Kit Cga Tfap2c Yy1 Tfap2a Egfr MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein Parp6 Gsk3a Parp8 Gsk3b Parp10 Parp9 Srpk1 Srpk2 Csnk1a1 Prmt1 Ube2i Parp14 Parp16 Parp4 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars Slc35d1 Slc35a2 Slc35c1 Slc35b4 Slc35d2 Slc35b3 Slc35b2 Slc35a1 Slc35a3 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes Creb3l4 Creb3l1 Creb3l2 Creb3l3 Mbtps1 Mbtps2 Creb3 Dcstamp Crebrf PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 96%8949664 Processing of SMDT1 Afg3l2 Smdt1 Mcub Pmpcb Yme1l1 Spg7 Micu2 Micu3 Pmpca Phb2 Micu1 Parl Maip1 Stoml2 Mcu Phb1 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma Egf Tgfa Ereg Areg Hbegf Btc Epgn Plcg1 Egfr PYROPTOSIS%REACTOME%R-HSA-5620971.6 Pyroptosis Gzmb Trp53 Elane Irf1 Chmp4c Chmp4b Casp3 Bak1 Casp4 Casp1 Il18 Gsdme Gsdmd Il1a Chmp2a Il1b Bax Trp63 Chmp3 Chmp7 Chmp6 Irf2 BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations Cyp51a1 Ugp2 Mtarc2 Mtarc1 Aoc3 Cyp2r1 Aoc2 Cmbl Ggt1 Nqo2 Cyb5r3 Cyp2u1 Cyp1b1 Cyp4a32 Cyp4f15 Sult1e1 Sult1a1 Abhd14b Sult1b1 Dpep1 Podxl2 Bpnt2 Dpep2 Adh4 Sult6b1 Sult4a1 Aldh1b1 Acss2 Sult2a1 Bpnt1 Adh1 Ggt5 Aldh2 Adh7 Acss1 Adh5 Maob Cyp4v3 Cyp39a1 Por Cyp11b1 Ces3b Cyp27b1 Cyp46a1 Ces2h Nr1h4 Cyp27a1 Cyp7a1 Cyp7b1 Ggt7 Akr7a2 Ugt2a1 Acsm1 Ggt6 Ugt2a2 Acy3 Ugt2a3 Ugt2b1 Mgst3 Mgst2 Ugdh Slc35d1 Mgst1 Ugt1a6 Ugt1a9 Uxs1 Gstk1 Ugt3a2 Ugt1a5 Abhd10 Fdx1 Ugt1a1 Nat1 Fdxr Paox Fdx2 Nat2 Ugt2b38 Ptgs1 Ugt2b36 Rxra Ugt2b34 Cyp19a1 Maoa Slc35d2 Gstz1 Gsta5 Chac1 Chac2 Gstm7 Gstm5 Gstm4 Gstm1 Gsto2 Esd Glyatl3 Cndp2 Hpgds Acsm2 Gstt2 Acsm4 Gstt1 Acsm5 Pomc Glyat Oplah Cyb5b Akr1a1 Gclc Cyp11a1 Gclm Fmo3 Fmo2 Tpmt Gsta3 Fmo1 Gstm2 Cyp2w1 Cyp2s1 Ahr Cyp2d22 Cyp3a16 Cyp3a13 Cyp3a57 Cyp2c65 Cyp2c55 Aoc1 Cyp2j6 Cyp2f2 Cyp2e1 Hsp90ab1 Cyp1a1 Cyp2b10 Ahrr Cyp4f14 Cyp2c50 Cyp1a2 Ptgis Tbxas1 Cyp2a5 Cyp8b1 Aldh1a1 As3mt Ahcy Nnmt Mtrr Trmt112 Ces1d Mat2a Gss Mtr Hemk2 Comt Cyp4f39 Cyp4f17 Gsto1 Cyp24a1 Mat2b Cyp4a12b Mat1a Cyp4f3 Tpst1 Cyp4f40 Tpst2 Cyp4b1 Acy1 Arnt Cyp21a1 Cyp11b2 Cyp26b1 Cyp26c1 Ncoa2 Cyp26a1 Ncoa1 Ugt1a2 Ephx1 Aip Aadac Bphl Aldh3a1 Cbr3 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins S100a9 S100a8 Ltf Lcn2 HCN CHANNELS%REACTOME DATABASE ID RELEASE 96%1296061 HCN channels Hcn2 Hcn3 Hcn4 Hcn1 RAS GTPASE CYCLE MUTANTS%REACTOME%R-HSA-9649913.5 RAS GTPase cycle mutants Kras Nras Hras PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-HSA-418360.3 Platelet calcium homeostasis Trpc3 Stim1 P2rx6 P2rx5 Itpr3 P2rx3 Itpr2 P2rx7 P2rx2 Itpr1 P2rx4 P2rx1 Atp2a1 Atp2a3 Atp2a2 Sri Slc8a1 Slc8a2 Slc8a3 Atp2b2 Trpc6 Atp2b1 Trpc7 Atp2b4 Atp2b3 Orai1 Orai2 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 96%9674555 Signaling by CSF3 (G-CSF) Jak2 Tyk2 Stat5a Stat5b Ptpn11 Gab2 Grb2 Csf3 Stat3 Stat1 Cul5 Socs1 Ube2d1 Lyn Csf3r Ube2d3 Ubc Kras Shc1 Jak1 Syk Hck Socs3 Eloc Rnf7 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases Col4a1 Col4a2 Col9a2 Col9a3 Col6a6 Mmp9 Jak3 Dlg4 Col6a3 Col4a5 Col9a1 Cdk5r1 Ap2m1 Cdk5 Prkacb Ap2a2 Cyfip2 Ap2a1 Itch Tns4 Tns3 Dock7 Adcyap1 Stub1 Ap2b1 Ap2s1 Bax Wasf3 Ptpn2 Ptpn18 Il2rg Hspb1 Id4 Ahcyl1 Adcyap1r1 Spint1 Hpn Ltk Tnk2 Mst1 Mst1r Spint2 Prkaca Spred1 Itpr3 Spred2 Itpr2 Itpr1 Rasa1 Mapk7 Gabrg2 Ptprz1 Gabrg3 Ptn Gabra1 Alkal1 Nrg1 Axl Gabrq Flt3 Gabrb1 Gabrb3 Rps6ka3 Gabrb2 Rps6ka2 Ppp2cb Cdh5 Ppp2ca Tiam1 Bdnf Gab1 Plcg1 Frs3 Ntf4 Ntrk2 Egr2 Dock3 Ntf3 Grin2b Egf Areg Vrk3 Adam10 Egr1 Ppp2r1b Ppp2r1a Adam17 S100b Dusp3 Dusp4 Dusp7 Dusp6 Mef2a Ppp2r5d Plat Flt4 Mdk Nab1 Csn2 Nab2 Stmn1 Trib1 Adap1 Arc Tph1 Pdgfd Rab4a Id2 Cilp Gga3 Id3 Fosl1 Thbs3 Egr3 Thbs4 Egr4 Dnal4 Mxd4 Lyl1 Ascl1 Rrad Cdk5r2 F3 Flt3l Vgf Map2k5 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Nrg2 Nrg4 Gtf2f1 Nrg3 Socs6 Memo1 Pxn Irs4 Prkca Igf2 Igf1 Trib3 Shb Sh2d2a Myc Nos3 Akt3 Akt2 Alk Akt1 Jund Hif1a Adora2a Lyn Spry2 Mknk1 Hgfac Yes1 Gfap Erbb2 Rac1 Fos Vav1 Pik3r1 Pik3r2 Yap1 Pak1 Fosb Pak3 Pak2 Grap2 Pdgfrb Stat3 Junb Ntrk3 Stat1 Ptpru Cma1 Rictor Grap Sh2b2 Sh2b3 Fer Mycn Tec Fes Wwox Tcf12 Pik3cb Igf1r Ranbp10 Pik3ca Wwp1 Prr5 Lrig1 Ptprk Pdpk1 Pag1 Fam83a Spry1 Them4 Cd274 Lck Mlst8 Ptpn6 Mtor Rhoa Prkcz Ptpn11 Fyn Csk Rps6ka5 Mapkap1 Nelfb Sin3a Erbin Ncbp2 Ncbp1 Itgb1 Ptpn1 Ins2 Dock1 Elmo2 Ptpn12 Stat5a Galnt3 Gipc1 Stat5b Cyfip1 Grb2 Tgfbr3 Ctsd Sgk1 Thbs2 Vegfa Sphk1 Nrp2 Usp8 Ptprs Ptprf Itgav Muc20 Ptk2 Dnm1 Dnm3 Ranbp9 Cxcl12 Nrp1 Flrt3 Nck2 Nck1 Flrt1 Flrt2 Prdm1 Flt1 Hsp90aa1 Ptk2b Elk1 Ptpro Clta Ereg Hbegf Cltc Btc Epgn Spp1 Pgf Dnm2 Egfr Adam12 Klb Fgf16 Fgf15 Irs1 Fgf18 Irs2 Fgf2 Pik3c3 Fgf1 Fgf4 Fgf10 Fgf3 Fgf6 Fgf7 Fgf9 Fgf20 Hdac2 Gab2 Fgf23 Fgfr4 Fgf22 Pde3b Tlr9 Pik3r4 Itga3 Pdgfb Srf Itga2 Sparc Tial1 Tia1 Esrp2 Rbfox2 Prkcd Nedd4 Matk Vegfd Vegfc Vegfb Thbs1 Insr Apoe Grb10 Stat6 Plg Bcar1 Tgfa Lama5 Lamb2 Lama1 Lamc3 Lamb3 Lama2 Lama3 Aamp Lama4 Socs1 Lamc1 Lamb1 Epn1 Lamc2 Arf6 Eps15l1 Prkcb Grb7 Ptprj Rnf41 Ubc Fam83b Ide Tab2 Esr1 Hdac1 Pgr Cul5 Rps6ka1 Kit Prkce Fgfrl1 Chd4 Id1 Rest Diaph1 Chek1 Cav1 Vav3 Jup Jak2 Rap1b Vav2 Itgb3 Hnrnpf Arhgef7 Hnrnpm Hnrnph1 Stam2 Sh3gl3 Src Cdc37 Sh3kbp1 Rock2 Stam Atp6v0b Ctnnb1 Eps15 Rock1 Atp6v0a2 Atp6v0a4 Cbl Hgs Atp6v1g3 Ctnnd1 Rab4b Sh3gl1 Atp6v0e2 Sh3gl2 Atp6v0a1 Met Atp6v1c2 Kdr Hgf Shc3 Atp6v1c1 Ptk6 Shc2 Shc1 Fgfbp3 Mapk1 Braf Fgfbp1 Ptbp1 Furin Mapk3 Pcsk5 Crkl Pcsk6 Ywhab Ncf1 Mapk12 Ncf2 Rap1a Ncf4 Atp6ap1 Mapkapk3 Brk1 Mapk13 Atp6v1e2 Atp6v1e1 Mapkapk2 Mapk14 Rala Ralb Tcirg1 Frs2 Ngf Baiap2 Kidins220 Atp6v1a Atp6v1b2 Ralgds Map2k2 Atp6v0d2 Nckap1l Rit1 Atp6v0d1 Atp6v1b1 Rit2 Nras Atp6v0e1 Ntrk1 Atp6v1g2 Map2k1 Atp6v1g1 Rapgef1 Sos1 Crk Atp6v1f Hras Atp6v1d Mapk11 Nckap1 Atp6v1h Wasf2 Wasf1 Ncor1 Atf2 Cyba Abi2 Ep300 Abi1 Cybb Mef2d Hnrnpa1 Hdac3 Dnmt1 Pdgfra Psen1 Psen2 Ncstn Aph1b Elmo1 Ctnna1 Col6a1 Col4a3 Mef2c Col6a2 Col4a4 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET Rap1b Lama5 Lamb2 Stat3 Lama1 Lamc3 Lamb3 Lama2 Lama3 Rab4a Lama4 Gga3 Lamc1 Lamb1 Lamc2 Arf6 Stam2 Sh3gl3 Src Sh3kbp1 Stam Eps15 Ptprj Tns4 Cbl Tns3 Hgs Dock7 Usp8 Rab4b Sh3gl1 Sh3gl2 Hgf Met Ubc Pik3ca Ranbp10 Muc20 Ptk2 Crkl Lrig1 Rap1a Ranbp9 Nras Ptpn2 Gab1 Rapgef1 Sos1 Crk Hras Ptpn11 Itga3 Itga2 Hgfac Spint1 Rac1 Itgb1 Hpn Ptpn1 Spint2 Pik3r1 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 96%9028731 Activated NTRK2 signals through FRS2 and FRS3 Frs2 Nras Bdnf Frs3 Ntf4 Sos1 Ntrk2 Hras Ptpn11 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Serp1 Sec61b Stx5 Prnp Ubl4a Get1 Emd Get3 Get4 Otof Camlg App Sgta Bag6 Vapa Vamp2 Stx1a Hmox1 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174411.6 Polymerase switching on the C-strand of the telomere Tinf2 Dscc1 Chtf18 Ctc1 Chtf8 Stn1 Ten1 Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Prim2 Rfc1 Prim1 Acd Rfc2 Pola2 Pold4 Pola1 Pold3 Terf2ip Terf2 Terf1 Pot1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D Gsk3b Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Ccnd1 Psmc4 Psmc3 Cdk4 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME%R-HSA-9918449.1 Defective visual phototransduction due to STRA6 loss of function Stra6 Ttr Rbp4 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 96%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) Gck ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 96%9914355 Isovaleric acidemia Ivd RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9828642 Respiratory syncytial virus genome transcription Hspa8 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 96%187042 TRKA activation by NGF Ngf Ntrk1 DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 F8 Tpst1 Tpst2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide Ca2 Car14 Ca4 Car9 Ca13 Ca3 Ca5b Ca5a Ca1 Car7 Car12 Car6 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9909438 3-Methylcrotonyl-CoA carboxylase deficiency Mccc1 Mccc2 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 96%2408552 Methylation of MeSeH for excretion Inmt BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME%R-HSA-2466712.4 Biosynthesis of A2E, implicated in retinal degradation Napepld DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) Slc5a1 DRUG ADME%REACTOME DATABASE ID RELEASE 96%9748784 Drug ADME Tpmt Impdh1 Bche Slc16a1 Gmps Nme2 Slco1b2 Hprt1 Nme1 Vav2 Abcc4 Gstm2 Guk1 Abcc5 Slc29a3 Slc29a2 Slc28a3 Ggt1 Slc28a2 Slc29a1 Xdh Sult1e1 Sult1a1 Cyp2d22 Cyp3a16 Cyp2c65 Itpa Sult2a1 Ggt5 Cyp2e1 Cyp2c50 Nt5c2 Adk Adal Pnp Ces1d Ces2h Akr1c21 Abcg2 Alb Ada Abcc1 Ggt7 Ugt2a1 Ugt2a2 Ggt6 Ugt2a3 Ugt2b1 Ugt1a6 Ugt1a9 Ugt3a2 Ugt1a5 Ugt1a1 Nat1 Nat2 Ugt2b38 Ugt2b36 Ugt2b34 Acy1 Abcc2 Glyatl3 Cndp2 Acsm2 Acsm4 Gstt1 Acsm5 Glyat Pon3 Pon1 Slco1a4 Abcc3 Slc22a2 Slc22a3 Slc22a8 Slc22a1 Abcb1a Rac1 Bsg Vav1 Serpina6 Hsd11b1 Hsd11b2 Ugt1a2 Vav3 Nudt15 Pck1 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-HSA-8951430.3 RUNX3 regulates WNT signaling Runx3 Myc Ctnnb1 Tcf7 Lef1 Ccnd1 Tcf7l1 Tcf7l2 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.5 Loss of Function of SMAD2 3 in Cancer Smad2 Smad3 Tgfb1 Smad4 Tgfbr1 Tgfbr2 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9603381 Activated NTRK3 signals through PI3K Pik3ca Irs1 Src Ntrk3 Pik3r1 Ntf3 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly Lamb3 Lama3 Itga6 Col17a1 Cd151 Itgb4 Lamc2 Plec CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 96%380615 Clearance of seratonin Maoa Slc6a4 Aldh2 CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle Prkaa2 Cpt1a Ppard Thrsp Cpt2 Cpt1b Slc22a5 Mid1ip1 Slc25a20 Prkab2 Rxra Prkag2 NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%8956320 Nucleotide biosynthesis Ppat Impdh1 Gmps Paics Umps Gart Cad Atic Adsl Dhodh Adss2 Pfas Adss1 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6793080 rRNA modification in the mitochondrion Mrm2 Mrm3 Ngrn Fastkd2 Trub2 Nsun4 Rpusd4 Tfb1m Mterf4 Mterf3 Rcc1l Mrm1 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME%R-HSA-5619108.3 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) Slc27a4 SIGNALING BY FGFR2%REACTOME%R-HSA-5654738.4 Signaling by FGFR2 Hnrnpf Hnrnpm Hnrnph1 Cbl Polr2c Ubc Polr2d Pik3ca Polr2a Polr2b Mapk1 Fgfbp3 Polr2g Braf Fgfbp1 Polr2h Mapk3 Polr2e Ptbp1 Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 Fgf16 Ppp2cb Frs2 Ppp2ca Fgf18 Fgf2 Fgf1 Nras Fgf4 Gab1 Fgf10 Plcg1 Fgf3 Frs3 Fgf6 Sos1 Fgf7 Fgf9 Hras Fgf20 Ptpn11 Fgf23 Fgf22 Spry2 Ppp2r1a Mknk1 Hnrnpa1 Tial1 Tia1 Esrp2 Rbfox2 Ncbp2 Ncbp1 Pik3r1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%419408 Lysosphingolipid and LPA receptors S1pr3 S1pr2 S1pr5 S1pr4 Lpar5 Plppr1 S1pr1 Plppr4 Lpar3 Plppr5 Lpar2 Plppr2 Lpar1 Plppr3 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 96%162791 Attachment of GPI anchor to uPAR Pigs Plaur Pigu Pigt Pigk Gpaa1 Pgap1 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 96%5387390 Hh mutants abrogate ligand secretion Sel1l Dhh Psma4 Psma3 Syvn1 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Derl2 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Vcp Psma7 Psmc6 Psmc5 Psmc2 Ihh Psmc1 Psmc4 Psmc3 Shh Ubc Psmd7 Psmd6 Psmd8 Erlec1 Psmd3 Psmd2 Psmd1 Hhat Os9 Adrm1 Sem1 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%937061 TRIF (TICAM1)-mediated TLR4 signaling Tlr4 Irf7 App Ikbkb Jun Birc3 Birc2 Traf3 Ikbkg Map3k7 Ticam2 Traf2 Ticam1 Cd14 Ikbke Tank Optn Nfkb1 Skp1 Fadd Fbxw11 Rela Ripk3 Btrc Casp8 Ripk1 Ube2d3 Ubc Nfkbib Irak1 Nfkbia Cul1 Traf6 Ube2n Chuk Ube2v1 Trp53 Tab3 Tab2 Tab1 Rps6ka1 Tifa Alpk1 Nfkb2 Fos Mapk9 Mapk7 Mapk8 Elk1 Map3k8 Ube2d1 Mapk1 Mapk3 Rps6ka3 Mapkapk3 Rps6ka2 Mapkapk2 Map2k7 Mapk14 Map2k6 Ppp2cb Ppp2ca Map2k4 Map2k3 Mapk10 Map2k1 Mapk11 Ptpn11 Ripk2 Tbk1 Rps6ka5 Irf3 Nkiras1 Atf2 Nkiras2 Lrrc14 Vrk3 Ikbip Ppp2r1b Ppp2r1a Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 N4bp1 Dusp7 Dusp6 Irak2 Ager Nlrx1 Mef2a Usp14 Usp18 Ppp2r5d Ly96 Mef2c FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 96%163210 Formation of ATP by chemiosmotic coupling Atp5f1d Atp5mk Atp5pb Atp5f1c Atp5pf Atp5mc3 Atp5mf Atp5me Dmac2l Atp5f1b ATP6 Atp5f1a SIGNALING BY GSK3BETA MUTANTS%REACTOME%R-HSA-5339716.5 Signaling by GSK3beta mutants Ppp2cb Ppp2ca Gsk3b Ctnnb1 Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME%R-HSA-9032845.3 Activated NTRK2 signals through CDK5 Rac1 Cdk5r1 Tiam1 Cdk5 Bdnf Ntrk2 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170984 ARMS-mediated activation Ngf Kidins220 Braf Ywhab Ntrk1 Rap1a Crk MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-HSA-947581.2 Molybdenum cofactor biosynthesis Mocos Mocs3 Mocs2 Gphn INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing Pabpn1 Cpsf4 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD Mat1a CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-HSA-174184.3 Cdc20:Phospho-APC C mediated degradation of Cyclin A Psma4 Psma3 Psma6 Psma5 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdk1 Cdc27 Ube2d1 Psmb5 Cdc16 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Ccna1 Psmd7 Ccna2 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cdc20 Mad2l1 Bub1b Bub3 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 96%5263617 Metabolism of ingested MeSeO2H into MeSeH Txnrd1 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 96%8983711 OAS antiviral response Oas3 Rnasel Pde12 Rigi Oasl1 Oas2 Flna Oas1g Abce1 VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways Tlr4 Fkbp1a Sap30l Ppia Suds3 Brms1 Rcor1 Jak3 Sap30 Tyk2 Sap18b Blnk Arid4b Crbn Arid4a Cd79a Cd79b Ifnar1 Hmg20b Ap2m1 Ifngr2 Ifngr1 Ywhae S1pr1 Sigmar1 Fnta Fntb Stat2 Il1r1 Sympk Cstf1 Papola Clp1 Nudt21 Ap2a2 Cpsf1 Cstf2 Ap2a1 Cpsf2 Cstf3 Cpsf3 Cstf2t Wdr33 Hdlbp Rbx1 Ap2b1 Ap2s1 P4hb Hspg2 Sdc4 Sdc3 Sdc2 Sdc1 Cul3 Cdc73 Rtf1 Gpc1 Gpc3 Leo1 Gpc2 Skic8 Gpc5 Gpc4 Gpc6 Ctr9 Paf1 Tyro3 Mapre3 Rb1 Mrc1 Emc4 Timd4 Cldn1 Mertk Rnasek Cd300a Axl Hspa5 Pros1 Ly6e Daxx Gas6 Agrn Nup37 Nup160 Nup43 Ranbp2 Dync1li2 Dync1li1 Nup107 Dynll1 Dynll2 Rps27 Dync1h1 Tkfc Nup85 Dync1i2 Dync1i1 Sec13 Ano10 Ano8 Ano7 Ppp1cc Taok1 Ano6 Ano5 Ano4 Ano2 Ano1 Nup133 Traf3 Cd14 Ikbke Hnrnpu Mta1 Tjp1 Mta3 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Parp14 Gtf2h1 Parp16 Nmt2 Gtf2f2 Galnt1 Gtf2h4 Parp4 Gtf2f1 Parp6 Gtf2h3 Supt5h Gsk3a Parp8 Gtf2h5 Parp10 Ercc2 Ccnh Parp9 Rnmt Ercc3 Cdk7 Rngtt H2ac20 Prkg2 Akt3 Akt2 Akt1 Rpn2 Rpn1 Lyn H2ac12 H2ac11 Vps36 Ubap1 H2ac15 Tsg101 Mvb12a H3c7 Mvb12b Ezh2 Vps37a Vps37b Vps37c Csnk2a2 Rcc1 Vta1 Ranbp1 Vps37d Suz12 Cd28 Snf8 Nmt1 Vps25 Ccr5 Chmp5 Vps28 Rac1 Vps4a Hist1h2bp Vps4b Jak1 Vav1 Pik3r1 Magt1 Pak2 Brd4 H2bc9 Tufm H2bc7 H2bc8 H2bc3 Tmem258 Stat1 Rictor Nek2 Ifih1 H2bu2 Sike1 Rnf135 Trim25 Mavs Stt3a Rigi Stt3b Srpk1 Srpk2 Vcp Cx3cr1 Rab5a Ostc Rab5c Rab5b Igf1r Tusc3 Hist2h2aa1 Prr5 Dad1 Ywhag Pdpk1 Ddost Csnk2b Eed Gsk3b Lck Mlst8 Csnk1a1 H2bc14 Ptpn6 Pdcd1 Mtor Cd4 Ptpn11 Fyn Cd209a H2bc21 H2bc26 Rbbp4 Rbbp7 Mapkap1 Ell Nelfa Nelfb Nelfe Taf15 Ctdp1 Taf11 Taf13 Taf12 Ccnk Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Taf9 Ncbp2 Ncbp1 Itgb1 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Taf8 Eloa Taf7 Taf6 Eloc Dock2 Taf5 Taf4 Taf3 Taf2 Taf1 Gja1 Ppp1ca Ppp1cb Cxcr4 Nrp1 Pabpc1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nck1 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Kpna1 Aaas Nup214 Banf1 Nup210 Nup155 Nup153 Slc25a5 Psip1 F2 Slc25a4 Hmga1 Dpm1 Rps14 Dpm2 Rpl4 Dpm3 Rps16 Rps18 Rps19 Eif2ak2 Rpsa Rpl37 Rpl39 Rps10 Kpnb1 Rps11 Rpl7 Hsp90aa1 Ipo5 Rpl32 Rps9 Rps7 Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Mlkl Grsf1 Tgfb1 Rps25 Rps26 Kpna4 Kpna7 Rps21 Kpna3 Cpsf4 Rpl39l Havcr1 Ace2 Isg15 Rps15a Tmprss2 Elk1 Dnajc3 Clta Parp1 Cltc Calr Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Hspa1a Rpl17 Arf1 Rpl18 Rpl19 Rpl10l Rpl11 Canx Rps3 Rps4x Pabpn1 Ran Hspa8 Comt Fasn Pik3c3 Rnps1 Srsf1 Srsf9 Cdc40 Srsf7 Srsf6 Tlr9 Pik3r4 Srsf3 Srsf2 Srsf11 Srrm1 Alyref Dhx38 U2af1l4 Il6ra Eif4a3 Elavl1 Clu Ube2l6 Atg7 Keap1 Vtn Ap1m2 Ap1m1 Pacs1 Ap1s3 Ap1s2 Ap1b1 Ap1s1 Ap1g1 B2m H2-Q10 H2bc18 Map1lc3b Becn1 Uvrag Iscu Ubr4 Traf6 Ube2n Uba5 Uba6 Uba7 Ube2v1 Tab3 Tab2 Tab1 Ywhah Hdac1 Acot2 Uba1 Uba3 Cul5 Ywhaz Il17rc Il17ra Phf5a Vps39 Hyou1 Crnkl1 Med9 Vps18 Vps11 Vps16 Btf3 Cdk19 Med13l Cav1 Dnajb11 Map1b Xab2 Aup1 Ipo7 Hnrnpa2b1 Zcrb1 Prpf19 Bag2 P4ha1 P4ha2 P4ha3 Puf60 Hnrnpul1 Impdh1 Vps41 Cd209d Vps45 Bcas2 Vhl Gpkow Smndc1 Aqr Pcbp2 Pcbp1 Grpel1 Hnrnpr Clint1 Nmi Sugp1 Hnrnpd Hnrnpf Hnrnpk Ccar1 Hnrnpl Hnrnpm Tlr1 Tlr6 Tlr2 Arih1 Rbmx Sftpd Hnrnph2 Hnrnph1 Cwc22 Sec11c Sec11a Hsp90ab1 Cwc27 Cpsf7 Hnrnpc Cwc25 Cwc15 Cbx1 Rock2 Rbm5 Vps33a Rock1 Vps33b Txnl4a Vim Oas2 Rrbp1 Snrnp200 U2surp Crb3 Patj Snrpb2 Pals1 Tomm70 Snrpa1 Furin Ptbp1 Kdelr1 Med22 Med21 Med28 Med29 Rptor Med11 Med19 Med18 Eif4g1 Atl2 Sf3a1 Sf3a2 Sf3a3 Dnajc10 Bcap31 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Sf3b5 Sf3b6 Nlrp12 Ctnnbl1 Rcan3 Srrt Snrnp40 Eftud2 H2-M5 H2-M3 Eif4e Snrpn G3bp1 G3bp2 Cherp Fus Chmp1a Isy1 Cdc5l Plrg1 Hnrnpa3 Ppil6 Ppil4 Cebpd Ppil3 H2-Q1 Hnrnpa1 Hnrnpa0 Ppil1 Prcc Cnbp Rbm10 Sar1b Elavl2 Bst2 Ufd1 Dhx16 Sec23a Dhx15 Nploc4 Scap Retreg1 Srrm2 Spcs3 Spcs1 Spcs2 Il17f Il17a Pex19 Prpf6 Elmo1 Hck Pdia3 Cd8b1 Ppig Sec24d Ppih Sec24c Ppie Ppib Prpf8 Sec24b Wbp11 Rtn3 Sec24a Pqbp1 Sp1 Clec5a Dnajc8 Ddx3x Sun2 Larp1 Rbm22 Mmp9 Rbm17 Ddx46 Ddx42 Dnaja2 Eif4g2 Eif4g3 Cd2bp2 Plcg2 Ddx23 Eif4e3 Chmp2a Btk Chmp3 Chmp7 Chmp6 Nlrp3 Itch Ripk3 Chmp4c Chmp4b Casp1 Ripk1 Pdcd6ip Syk Pycard Cysltr1 Lig1 Atp1a2 Fxyd4 Atp1a1 Fxyd1 Atp1a3 Fxyd7 Fxyd6 Camk2g Camk2d Camk2b Camk2a Atp1b1 Atp1b3 Atp1b2 Ifnb1 Ripk2 Bcl2l1 Gemin7 Gemin4 Nod2 Gemin5 Nod1 Snrpb Smn1 Snrpd2 Snrpd1 Irak2 Snrpd3 Gemin2 Ddx20 C4a Exoc1 Tubb5 Ganab Mgat5 Zdhhc9 Man2a1 Zdhhc11 Mgat2 Mgat1 Mogs Golga7 Edem2 Fut8 St6galnac3 St6galnac4 St6galnac2 St3gal4 Mgat4c Mgat4a St3gal2 Mgat4b St3gal1 Man1b1 Zdhhc20 Prkcsh St6gal1 Zdhhc8 Zdhhc5 Zdhhc3 Zdhhc2 Med8 Med4 Med6 Gbf1 Gatad2a Gatad2b Tal1 Gps2 Cog1 Itga4 Cdk8 Pml Xrn1 Havcr2 Kdm1a Ddx5 Fkbp4 Nedd4l Irak1 Ybx1 Trim28 Sfn Med23 Med24 Med25 Med20 Med26 Med27 Med12 Med13 Med14 Med10 Med15 Med16 Med17 Ncor2 Mbd3 Egfr Fen1 Med30 Med31 Hdac2 Eif4a2 Eif4a1 Nrbp1 H2ac21 H2ac25 Hist1h2af H2ac1 Tlr8 Tlr7 Tlr3 Ccnc C1qa C1s2 Mbl2 Cgas Sting1 Prmt1 Irf7 Psma4 Dhx9 Ikbkb Psma3 Psma6 Psma5 Xrcc6 Psma2 Xrcc5 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rela Npm1 Btrc Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Nfkbib Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Chuk Nr3c1 Smad3 Smad4 Ube2i Chd3 Chd4 Rest Mta2 Jak2 Sh3kbp1 Ctnnb1 Fip1l1 Ywhab Sos1 Atp6v1h Tbk1 Zbp1 Irf3 Ncor1 Ep300 Tbl1x Lig4 Xrcc4 Hdac3 Xpo1 Tbl1xr1 Med1 Nfe2l2 Ly96 Crebbp Apoa1 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases Atp2c1 Atp2c2 Atp10a Atp10b Atp10d Atp8a1 Atp8a2 Atp4a Atp4b Atp11b Atp2a1 Atp11a Atp13a1 Atp1a2 Atp11c Fxyd4 Atp8b2 Atp1a1 Atp8b1 Atp2a3 Atp8b3 Fxyd1 Atp13a2 Atp2a2 Atp13a4 Atp1a3 Atp13a5 Atp12a Fxyd7 Sri Fxyd6 Atp9b Atp9a Camk2g Camk2d Pdzd11 Camk2b Camk2a Atp1b1 Atp7b Atp1b3 Atp2b2 Atp1b2 Atp7a Atp2b1 Atp2b4 Cutc Atp2b3 PACKAGING OF TELOMERE ENDS%REACTOME%R-HSA-171306.5 Packaging Of Telomere Ends H2bu2 H2ac12 H2ac11 Acd H2ac15 H2bc14 H2bc9 H2ax H2bc7 Terf2ip H2ac20 H2bc8 H2bc3 Tinf2 H2bc21 Terf2 Hist1h2bp Terf1 H2bc26 Hist2h2aa1 H2aj H2ab2 H3c8 Pot1 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%111465 Apoptotic cleavage of cellular proteins Satb1 Bcap31 Gsn Bmx Casp7 Gas2 Dbnl Add1 Plec Birc2 Clspn Fnta Stk26 Stk24 Lmnb1 Apc Acin1 Ctnnb1 Prkcd Dsp Rock1 Tjp1 Vim Casp3 Casp8 Pkp1 Dsg2 Cdh1 Dsg3 Dsg1a Tjp2 Casp6 Ptk2 Prkcq Sptan1 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism Csf2rb2 Csf2ra Galnt3 Muc15 Ggt1 Muc13 Pomgnt1 Galnt12 Cyp2u1 Adamts1 Cyp1b1 Adamts5 Adamts4 Adamts3 Adamts2 Adamts8 Amn Adamts7 Adamts6 Sema5a Pah Sema5b C1galt1 Thsd1 Thbs2 C1galt1c1 Thsd4 Adamts13 Adamts14 Adamts15 Large1 Adamts16 Cfp Adamts18 Adamts19 Notch1 Spon2 Muc1 Spon1 Adamts10 Sbspon Adamts12 B3glct Pmm2 Mpi Muc4 Cyp11b1 Muc6 Cyp27b1 Thsd7a Muc20 Adamtsl1 Adamtsl2 Adamtsl3 Abca3 Adamtsl4 Adamtsl5 Pomt1 Adamts20 Dag1 Thsd7b Lfng Pomt2 Cubn Idh1 Slc35d1 Chsy1 Nhlrc1 Ugt1a5 Ugt1a1 Chst14 Sftpc Galt Omd Hspg2 Sdc4 Sdc3 Sdc2 Gns Ppp1r3c B4galt7 Srd5a3 Oplah B4gat1 B4galt1 Dhdds Ext2 Ext1 Sdc1 Dpm1 Dpm2 Dpm3 Gbe1 Ctsa Gclc Cyp11a1 Gne Khk Gclm Gys1 Gys2 Dolk Gaa Sftpa1 Chst3 Gfpt1 Neu1 Chst5 Nus1 Pcx Aldob Hexa Hexb Gpc1 Idua Ncan Bgn Gpc3 Cspg5 Gpc2 Cspg4 Dcn Bcan Gpc5 Vcan Gpc4 Glb1 Fmod Pcca Gpc6 Mmaa Ids Pccb Mmut Hyal1 Arsb Gusb Tbxas1 Mmab Epm2a Mmadhc Mmachc Papss2 Alg14 Naglu Acat1 Kera Ahcy Mtrr Slc37a4 Agrn Mtr Hibch Mccc1 Cyp17a1 Gyg1 Auh Cyp4f39 Ivd Mccc2 Cyp24a1 Mat1a Ppm1k B3galt6 Slc26a2 Btd G6pc1 Cd320 Galk1 Cblif Hgsnat Alg9 Alg8 Alg6 G6pc3 Alg3 Alg2 Ogn Alg1 Sftpb Mpdu1 Rft1 Dpagt1 Hlcs Pgm1 Cyp21a1 Cyp11b2 Taldo1 Rpia Gale Thbs1 B3gat3 Galm Prelp Galns Lum Sgsh Sis Cyp2r1 Dcxr Lct Ubc Aprt Pnp Cyp27a1 Ada Cyp7b1 Tcn2 Mgat2 Mogs Fdx1 Fdxr Fdx2 Cyp19a1 Alg11 Maoa Man1b1 Notch4 Notch2 Notch3 Pomc Lmbrd1 Fmo3 Tpmt Hprt1 Abcd4 Echs1 Sftpd Mc2r Gss Slc25a15 Arg1 Nags Asl Acy1 Cps1 Nmral1 Ass1 Otc Slc34a2 Bckdhb Bckdk Bckdha Dbt Cyp26b1 Dld Cyp26c1 Acaca INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling Cntf Cntfr Jak2 Clcf1 Osm Lifr Ctf1 Il6ra Crlf1 Cbl Tyk2 Lif Ptpn11 Stat3 Jak1 Il31ra Stat1 Il11 Socs3 Il6st Osmr Il6 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 96%9706369 Negative regulation of FLT3 Csk Socs6 Flt3l Sla2 Socs2 Abl2 Sla Flt3 Ptprj Cbl Sh2b3 Ubc DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME%R-HSA-9820448.2 Developmental Cell Lineages of the Exocrine Pancreas Fgf2 Fgf4 Fgf10 Fgf7 Egf Fn1 Lama5 Vtn Lamb2 Lama1 Lamc3 Lamb3 Lama2 Lama3 Lama4 Lamc1 Lamb1 Lamc2 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-HSA-2162123.6 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Hpgds Akr1c18 Ptgis Tbxas1 Cyp8b1 Ptgr2 Ptgs1 Hpgd Ptgds Ptgs2 Ptges Ptges2 Prxl2b Cbr1 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins Alox5 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death Bcl2l1 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS Muc6 Muc20 Muc1 C1galt1 Muc15 Muc13 C1galt1c1 Muc4 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%75953 RNA Polymerase II Transcription Initiation Gtf2h3 Taf4 Taf3 Gtf2h5 Taf2 Ercc2 Taf1 Ccnh Ercc3 Cdk7 Taf15 Taf11 Taf13 Taf12 Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Polr2c Taf9 Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Taf8 Gtf2h2 Gtf2h1 Taf7 Gtf2f2 Taf6 Gtf2h4 Gtf2f1 Taf5 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111457 Release of apoptotic factors from the mitochondria Diablo Gsdmd Bax Bak1 Gsdme ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111446 Activation of BIM and translocation to mitochondria Bcl2l11 Dynll1 Mapk8 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism Elovl3 Elovl5 Abcd1 Elovl1 Acsl1 Fads2 Fads1 DEFECTIVE MUT CAUSES MMAM%REACTOME%R-HSA-3359478.5 Defective MUT causes MMAM Mmaa Mmut REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion Prkaca Cacnb2 Cacna1d Cacna1e Kcnj11 Cacna1a Itpr3 Itpr2 Itpr1 Ffar1 Prkacb Gna11 Gna15 Stxbp1 Gna14 Adcy8 Adcy5 Adcy6 Gnaq Gnai2 Rap1a Gnai1 Adra2a Marcks Adra2c Prkar1b Chrm3 Glp1r Syt5 Prkar2b Plcb3 Plcb2 Plcb1 Gng10 Prkca Kcng2 Akap5 Cd36 Cacna1c Gng3 Gng2 Prkar1a Gng4 Snap25 Gng7 Vamp2 Gng8 Stx1a Slc2a1 Kcnb1 Prkar2a Kcns3 Gngt1 Gngt2 Acsl3 Acsl4 Slc2a2 Kcnc2 Ahcyl1 Gcg Abcc8 Gnb2 Rapgef4 Gnb1 Rapgef3 Gnb4 Gnb3 Cacna2d2 Gnb5 Gng11 Ins2 Gng12 Cacnb3 Gng13 Iqgap1 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2142789 Ubiquinol biosynthesis Pdss2 Coq8a Coq8b Pdss1 Coq2 Coq3 Coq4 Coq5 Coq6 Hpdl Coq7 Coq9 Stard7 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism Lrp2 Mmab Mmadhc Ctrb1 Mmachc Cd320 Abcd4 Cblif Prss2 Mtrr Ldlrap1 Amn Mtr Abcc1 Mmaa Lmbrd1 Mmut Tcn2 Cubn DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome Kcnj11 Abcc9 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 96%1483148 Synthesis of PG Pld4 Pld3 Cds2 Pld2 Pgs1 Pld1 Ptpmt1 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events Prkaca Prkar2b Camkk1 Camkk2 Prkca Prkcg Prkx Prkar1a Prkacb Camk4 Prkar2a Grk2 Pde1b Pde1c Prkcd Adcy3 Pde1a Adcy4 Adcy1 Adcy2 Adcy7 Camk2g Adcy8 Adcy5 Camk2d Adcy6 Camk2b Adcy9 Camk2a Prkar1b CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 96%5674400 Constitutive Signaling by AKT1 E17K in Cancer Bad Gsk3a Gsk3b Akt1s1 Mlst8 Foxo4 Tsc2 Mtor Mdm2 Foxo1 Akt3 Akt2 Cdkn1a Akt1 Cdkn1b Prr5 Rictor Rps6kb2 Pdpk1 Mapkap1 Foxo3 Nr4a1 Chuk Casp9 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9937850 NuRD complex assembly H2bc9 H2bc7 H2bc8 H2bc3 Gatad2a Gatad2b H2ab2 Mbd3 H2bu2 Mta1 Mta3 Nr2c2 Hist2h2aa1 Phf6 Zfp592 Tcf19 Cdk2ap1 G6pc1 Cdk2ap2 Nr2f2 Mbd2 Zmynd8 Ikzf3 H2bc14 Znf687 Ikzf2 H2ac20 Ikzf1 Pwwp2a Chd5 Mbd3l1 Hdac2 Hdac1 Zfp827 Pwwp2b Ube2i H2bc21 H2bc26 Rbbp4 Rbbp7 Chd3 Chd4 H2ac12 H2ac11 H2ac15 H3c7 H2ax Fbp1 Mta2 Hist1h2bp H2aj Pck1 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 96%422475 Axon guidance Col4a1 Pitpna Plxnd1 Col4a2 Col9a2 Dlg1 Col9a3 Dlg3 Col6a6 Mmp9 Dlg4 Col6a3 Ppp3cb Col4a5 Col9a1 Arpc1b Actr2 Arpc1a Cdk5r1 Ap2m1 Actr3 Sdcbp Cdk5 Prkacb Arpc3 Arpc2 Ap2a2 Ap2a1 Arpc5 Arpc4 Rbx1 Ap2b1 Ap2s1 Reln Vldlr Dab1 Wasl Myo10 Sdc2 Gdnf Gfra1 Prkaca Rasa1 Mapk7 Epha1 Neo1 Gpc1 Ncan Rps6ka6 Agrn Clasp1 Clasp2 Rps6ka3 Rps6ka2 Farp2 Tiam1 Gab1 Plcg1 Grin2b Rps27 Adam10 Efna1 Efna2 Efna3 Mmp2 Epha3 Epha4 Epha5 Epha6 Epha7 Epha8 Ephb1 Ephb3 Ephb4 Ephb6 Efnb1 Efnb2 Efnb3 Efna4 Efna5 Robo1 Srgap1 Srgap2 Srgap3 Arhgap39 Slit2 Prkca Cacna1c Lyn Yes1 Grin1 Myh9 Csnk2a2 Myl12a Erbb2 Rac1 Pik3r1 Pik3r2 Unc5b Unc5a Pak1 Pak3 Pak2 Ret Fes Pik3cb Pik3cd Pik3ca Csnk2b Gsk3b Itga5 Rhoa Ptpn11 Fyn Rps6ka5 Abl1 Epha2 Itsn1 Ncbp2 Cacna1g Ncbp1 Myl12b Itgb1 Cacna1h Kalrn Myh11 Cacna1i Eloc Dock1 Myl6 Cacna1d Pak4 Arhgap35 Trio Sema5a Actb Spta1 Nrp2 Scn9a Scn5a Sptb L1cam Scn1a Scn1b Lypla2 Kcnq3 Itgav Kcnq2 Numb Ptk2 Shtn1 Gap43 Ank3 Chl1 Nell2 Msi1 Ank1 Scn10a Cxcr4 Dag1 Scn2a Isl1 Scn2b Upf3a Dnm1 Pfn1 Kif4 Sptan1 Gspt2 Gspt1 Dnm3 Pfn2 Rps6ka4 Vasp Dcx Ranbp9 Cxcl12 Abl2 Ezr Lhx2 Scn7a Lhx3 Shank3 Scn11a Cul2 Scn3a Lhx9 Scn3b Lhx4 Ephb2 Itga9 Nrp1 Pabpc1 Itga10 Dpysl2 Flrt3 Alcam Slit1 Nfasc Slit3 Nck2 Scn8a Rdx Akap5 Nck1 Ncam1 Cap1 Msn Dcc Itga2b Nrcam Upf2 Scn4a Sptbn1 Usp33 Zswim8 Scn4b Sptbn2 Evl Etf1 Cntn2 Sos2 Cntn1 Cntnap1 Robo2 Cntn6 Hoxa2 Sptbn4 Ntn1 Pak6 Myo9b Pak5 Cap2 Prkar2a Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 St8sia4 Rps10 Rps11 Rpl7 Hsp90aa1 Rpl32 Cacnb3 Cacnb4 Rps9 Rps7 Cacnb1 Rps5 Rpl24 Cacnb2 Rpl26 Rpl22 Rpl23 Rps25 Rps26 St8sia2 Rps21 Rpl39l Rps15a Clta Cltc Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Cltb Rps3 Rps4x Dnm2 Hspa8 Egfr Irs2 Rnps1 Gab2 Magoh Rbm8a Upf3b Itga1 Itga2 Eif4a3 Casc3 Magohb Trpc6 Trpc5 Cfl1 Trpc7 Siah2 Trpc1 Trpc4 Trpc3 Grb10 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Lama1 Psmd12 Psmd11 Psmd14 Psmd13 Lamc1 Lamb1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Grb7 Psma7 Psmc6 Pip5k1c Psmc5 Psmc2 Rnd1 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Plxna1 Psmd8 Psmd3 Plxna4 Psmd2 Psmd1 Adrm1 Sem1 Prkcq Ldb1 Rps6ka1 Agap2 Crmp1 Dscaml1 Rap1gap Tyrobp Ptprc Ptpra Ntn4 Unc5d Rhob Trem2 Unc5c Sema7a Arhgef11 Rgmb Rgma Artn Gfra2 Gfra3 Gfra4 Siah1a Dpysl3 Arhgef28 Dpysl4 Dpysl5 Cd72 Plxnb3 Cacna1s Plxna3 Plxna2 Dok1 Vav3 Dok2 Dscam Dok4 Dok5 Dok6 Prnp Pspn Plxnc1 Vav2 Nrtn Sema6d Sema6a Hjv Sema4a Itgb3 Ablim1 Rhoc Ablim2 Plxnb1 Ablim3 Tln1 Sema3a Ngef Sema3e Arhgef7 Actg1 Hsp90ab1 Src Sh3kbp1 Rock2 Rock1 Myh14 Myh10 Sema4d Rras Limk1 Limk2 Sh3gl2 Met Shc3 Shc1 Mapk1 Mapk3 Eif4g1 Frs2 Git1 Map2k2 Nras Map2k1 Sos1 Hras Psen1 Psen2 Ncstn Aph1b Col6a1 Col4a3 Col6a2 Col4a4 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors Plcb3 Gngt1 Gngt2 Plcb2 Plcb1 Gng10 Grik3 Gng3 Gng2 Gnb2 Gnb1 Gng4 Gnb4 Gnb3 Gng7 Gnb5 Gng11 Gng8 Gng12 Gng13 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases Arsb Arsi Arsg Sumf1 Arsk Sumf2 Arsa Arsj DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME%R-HSA-9662001.3 Defective factor VIII causes hemophilia A F2 Vwf F8 F9 F10 Tpst1 Tpst2 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function Topbp1 Rpa2 Rad17 Rbbp8 Brca2 Brca1 Rad51ap1 Xrcc2 Rpa3 Rad1 Atm Kat5 Exo1 Nbn Rfc5 Rfc3 Rfc4 Rfc2 Hus1 Atrip Brip1 Dna2 Rad51c Rad51d Blm Rad51b Rad9a Bard1 Rad9b Top3a Wrn Mre11a Palb2 Sem1 Rad51 Rad50 Rpa1 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 96%71240 Tryptophan catabolism Aadat Kynu Slc36a4 Slc3a2 Tdo2 Afmid Slc7a5 Ido2 Acmsd Haao Ido1 Kmo Kyat1 Kyat3 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME%R-HSA-9617629.2 Regulation of FOXO transcriptional activity by acetylation Kat2b Txnip Crebbp Txn Foxo4 Foxo3 Ep300 Sirt1 Sirt3 Foxo1 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling Tgfbr3 Fgf2 Gipc1 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.3 Loss of Function of TGFBR1 in Cancer Fkbp1a Smad2 Smad3 Tgfb1 Tgfbr1 Tgfbr2 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters Slc34a3 Slc34a2 Slc20a2 Slc17a1 Slc20a1 Slc34a1 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen Vwf Gp9 Gp1bb Gp5 Gp1ba DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 96%3595177 Defective CHSY1 causes TPBS Ncan Bgn Chsy1 Cspg5 Cspg4 Dcn Bcan Vcan DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER Gtf2h3 Rpa2 Gtf2h5 Ercc2 Ercc3 Rpa3 Polk Parp2 Pole Ddb1 Parp1 Xpa Cul4a Cul4b Rfc5 Pold2 Pold1 Ercc1 Rfc3 Ercc4 Pcna Ercc5 Rfc4 Chd1l Rfc1 Rfc2 Pold4 Pold3 Rbx1 Pole3 Pole2 Ubc Pole4 Gtf2h2 Gtf2h1 Gtf2h4 Ddb2 Rpa1 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%77387 Insulin receptor recycling Atp6v1a Insr Atp6v1b2 Ide Atp6v0d2 Atp6v0d1 Atp6v1b1 Atp6v0e1 Atp6v1g2 Atp6v1g1 Atp6v1f Atp6v1d Atp6v1h Ctsd Atp6v0b Atp6v0a2 Atp6v0a4 Atp6v1g3 Atp6v0e2 Atp6v0a1 Atp6v1c2 Atp6v1c1 Ptprf Ptpn1 Atp6ap1 Ins2 Atp6v1e2 Atp6v1e1 Tcirg1 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Eif2s3x Eif2s2 Eif2s1 Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Eif2ak4 Gcn1 Impact Cebpb Trib3 Asns Atf3 Atf2 Rps27 Cebpg Rps14 Rpl4 Atf4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Ddit3 Rps11 Rpl7 Rpl32 Rps9 Rps7 INTERLEUKIN-1 SIGNALING%REACTOME%R-HSA-9020702.4 Interleukin-1 signaling Psma4 App Ikbkb Psma3 Psma6 Psma5 Psma2 Peli1 Psma1 Ikbkg Map3k7 Traf2 Psmd12 Psmd11 Psmd14 Psmd13 Map3k8 Sqstm1 Nfkb1 Skp1 Il1r1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Rela Btrc Rbx1 Psma7 Psmc6 Psmc5 Casp8 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Il1a Nfkbib Il1b Psmd8 Psmd3 Psmd2 Psmd1 Irak1 Nfkbia Adrm1 Sem1 Traf6 Cul1 Ube2n Chuk Map2k6 Ube2v1 Trp53 Map2k4 Tab3 Tab2 Tab1 Map2k1 Il1r2 Il1rn Irak3 Ripk2 Myd88 Nkiras1 Nkiras2 Lrrc14 Ikbip Peli2 Peli3 Tnip2 Saa3 Nod2 Nod1 Map3k3 S100b Irak4 N4bp1 Tifa Alpk1 Irak2 Ager Nlrx1 Nfkb2 Usp14 Usp18 Tollip MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 Gab1 Hgf Ptpn11 Met TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%9013957 TLR3-mediated TICAM1-dependent programmed cell death Ticam1 Ripk3 Tlr3 Casp8 Ripk1 Fadd LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME%R-HSA-9723905.2 Loss of function of TP53 in cancer due to loss of tetramerization ability Trp53 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se Ahcy Hnmt Nnmt Cth Mat1a Gnmt Scly Cbs DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 96%114516 Disinhibition of SNARE formation Stxbp3 Prkcb Prkca Prkcg Stx4 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction Pnlip Apoe Awat2 Lrp10 Gpc1 Lrp12 Grk1 Gpc3 Gpc2 Gpc5 Fnta Gpc4 Fntb Rlbp1 Gpc6 Lrp1 Lrp2 Bco2 Bco1 Ttr Apoa2 Ldlr Apoa4 Cyp4v3 Metap1 Metap2 Rbp4 Rbp2 Lpl Rbp3 Gpihbp1 Rcvrn Rbp1 Myo7a Rdh12 Apoc2 Agrn Plb1 Akr1c21 Abca4 Apoc3 Akr1c6 Nmt2 Prkcq Opn1mw Hsd17b6 Lrat Pde6g Prkca Hsd17b1 Pde6a Pde6b Rpe65 Apom Opn1sw Gucy2e Slc24a1 Retsat Sag Rho Hspg2 Gnat1 Cnga1 Gucy2f Sdc4 Sdc3 Sdc2 Rdh8 Dhrs3 Rdh11 Rdh10 Akr1c18 Camkmt Gngt1 Rdh16f2 Rdh5 Dhrs9 Sdc1 Nmt1 Rgs9bp Ppef1 Stra6 Gnb1 Akr1b10 Apoa1 Guca1b Guca1a Sdr9c7 Clps Apob AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis Agmat Azin2 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling Egf Tgfa Ereg Areg Hbegf Btc Epgn Nras Sos1 Hras Egfr BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-HSA-446193.3 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Gfpt1 Gfpt2 Neu1 Dhrsx St6galnac1 St3gal6 Nus1 Slc35c1 St3gal5 Nanp Fpgt Gfus St8sia2 Nans St8sia3 St8sia1 Glb1 Slc17a5 Alg10b Alg14 Gmppa Pmm2 Mpi Gmppb Pmm1 St6galnac6 St6galnac3 St6galnac4 St6galnac2 St3gal4 Alg11 St3gal2 Hk1 Alg9 Alg8 St3gal1 Alg6 Alg3 Alg2 Alg1 St6gal1 Mpdu1 Rft1 Dpagt1 Amdhd2 Gnpnat1 Srd5a3 Pgm3 St6galnac5 Cmas Dhdds Nudt14 Alg5 Slc35a1 Dolpp1 Fuom Dpm1 Dpm2 Dpm3 Mvd Gmds St6gal2 Renbp Ctsa Gne St8sia6 St8sia4 St8sia5 Uap1 Dolk Npl Neu2 Neu3 Neu4 Nagk Fcsk ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 96%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Rps27l Rplp2 Rps27 Rpl22l1 Rplp1 Ube2d1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Znf598 Rps14 Ube2d3 Rpl4 Ubc Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Ascc3 Ascc2 Rps11 Rpl7 Rpl32 Rps9 Rps7 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 96%400206 Regulation of lipid metabolism by PPARalpha Sp1 Srebf2 Havcr2 Angptl4 Esrra Cyp4a32 Nr1h3 Fabp1 Sult2a1 Pex11a Ncoa3 Apoa2 Apoa5 Ppargc1b Acsl1 Nr1h4 Abca1 Rxrb Slc27a1 Cyp7a1 Ugt1a9 Nr1h2 G0s2 Rora Ppara Pparg Alas1 Tnfrsf21 Trib3 Rxra Ankrd1 Cd36 Txnrd1 Fhl2 Grhl1 Plin2 Cpt2 Med9 Fads1 Agt Cdk19 Med13l Abcb4 Me1 Med8 Med4 Med23 Med6 Med24 Med25 Med20 Med26 Med27 Med12 Med13 Med14 Med10 Tiam2 Med15 Med16 Med17 Ncor2 Ahr Cyp1a1 Ahrr Nrf1 Gps2 Hmgcs2 Med22 Med21 Med28 Med29 Med11 Med19 Med30 Med18 Med31 Rgl1 Thrap3 Fam120b Ncor1 Helz2 Carm1 Cdk8 Ep300 Tbl1x Arnt Clock Fdft1 Sin3a Bmal1 Hdac3 Ncoa2 Ncoa1 Tbl1xr1 Smarcd3 Acadm Mtf1 Ncoa6 Npas2 Med1 Cpt1a Nr1d1 Nfyb Glipr1 Nfya Nfyc Ppargc1a Ccnc Crebbp Apoa1 Chd9 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Psma4 Fbxl18 Psma3 Psma6 Fbxl7 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Aurka Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex Smarcd1 Actl6a Smarcd2 Smarce1 Phf10 Smarcc2 Smarcc1 Bcl7a Bcl7b Bcl7c Smarcd3 Brd7 Smarcb1 Arid2 Pbrm1 Smarca2 Smarca4 Actb DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.3 Defective factor IX causes thrombophilia F8 F9 F10 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins Psma4 Psma3 Psma6 Psma5 Plk1 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdk1 Cdc27 Ube2d1 Psmb5 Cdc16 Nek2 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Ccna1 Psmd7 Ccna2 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cdc20 Mad2l1 Bub1b Pttg1 Bub3 DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 96%3359485 Defective CD320 causes MMATC Cd320 Tcn2 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME%R-HSA-5619078.3 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) Slc35c1 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense Gbp9 Casp4 Gbp2 Gbp3 Ubc DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 96%5693606 DNA Double Strand Break Response Brca1 Mapk8 H2bc9 H2bc7 H2bc8 Atm H2bc3 Chek2 H3c8 Kdm4b H2bu2 Ubc Ube2n Ube2v2 Trp53 H2bc14 Pias4 Ube2i H2bc21 H2bc26 Kat5 Abl1 Trp53bp1 Abraxas1 Nbn Brcc3 Rnf168 Nsd2 Baz1b Babam1 Babam2 Uimc1 Mdc1 Bap1 Ppp5c Apbb1 Kdm4a Smarca5 H2ax Eya2 Eya1 Eya4 Eya3 Ubxn1 Hist1h2bp Bard1 Mre11a Herc2 Rad50 MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 96%1221632 Meiotic synapsis Sun2 Brca1 H2bc14 Rad21 H2bc9 H2bc7 H2ac20 H2bc8 Tinf2 H2bc3 Syce2 Syce3 Ube2i Syce1 H2bc21 Sun1 Tex12 Sycp1 H2bc26 Sycp2 Syne1 Smc1a Syne2 Fkbp6 H2ab2 Sycp3 H3c8 Stag3 Rec8 Smc1b Stag2 Lmnb1 Stag1 H2bu2 H2ac12 H2ac11 Acd H2ac15 H2ax Terf2ip Terf2 Hist1h2bp Terf1 Hist2h2aa1 H2aj Smc3 Pot1 Hspa2 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 96%420597 Nectin Necl trans heterodimerization Cadm3 Cadm1 Nectin1 Nectin2 Nectin3 Nectin4 CARDIOGENESIS%REACTOME DATABASE ID RELEASE 96%9733709 Cardiogenesis Hey2 Gata4 Hey1 Smad1 Lef1 Smad4 Foxo4 Ldb1 Kat5 Srf Eomes T Gata6 Tbx5 Ctnnb1 Smyd1 Mesp1 Tbx1 Tbx20 Hand1 Hand2 Myocd Kat2a Isl1 Mef2c Nkx2-5 Wdr5 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition Fbxo5 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Cdc25a Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Mnat1 Psmd1 Adrm1 Sem1 Cul1 Ccnh Cdk7 Hdac1 Myc Rbl2 Akt3 Akt2 Akt1 Tyms Dhfr Tk1 Rbl1 Pcna Orc5 Orc4 Orc6 Orc1 Mcm8 Orc3 Orc2 Pole3 Pole2 Pole4 Rrm2 Rpa1 Rpa2 Rpa3 Cdc7 Pole Cdk1 Ccne1 Ccne2 Tfdp2 Tfdp1 Skp2 Rb1 Ccnd1 Mcm7 Cdk4 Cdk2 Mcm3 Ptk6 Mcm4 E2f1 Ccna1 Cks1b Mcm5 Ccna2 Cables1 Mcm6 Max Lin54 Cdc45 Cdkn1a Mcm2 Cdkn1b Cdt1 Lin9 Gmnn Wee1 Lin37 Dbf4 Mcm10 Ppp2cb Ppp2ca Cdc6 Rbbp4 Ppp2r1b Ppp2r1a Prim2 Prim1 Pola2 Pola1 E2f4 E2f5 E2f6 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination Mterf1b DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME%R-HSA-5619089.4 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) Slc6a5 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance Amn Hdlbp Apoa1 Cubn TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes Cnot9 Cnot6l Trp53 Cnot8 Cnot11 Prmt1 Plk3 Rbl2 Cnot10 Rbl1 Pcbp4 Aurka Btg2 Zfp385a Cdk1 Carm1 Cdc25c Ep300 Pcna Ccne1 Ccne2 Tnks1bp1 Npm1 Gadd45a Tfdp2 Tfdp1 Plk2 E2f4 E2f7 Cdk2 E2f8 E2f1 Ccna1 Ccna2 Cdkn1a Bax Rgcc Sfn Cdkn1b Cpap Cnot3 Cnot2 Cnot1 Cnot7 Cnot6 Cnot4 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 96%5357786 TNFR1-induced proapoptotic signaling Usp2 Sharpin Usp21 Tnf Spata2 Casp8 Rnf31 Usp4 Tnfrsf1a Rbck1 Cyld Ripk1 Otud7b Tnfaip3 Birc3 Mib2 Birc2 Tbk1 Tradd Traf2 Ikbke Xiap Optn Fadd RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 96%5660526 Response to metal ions Csrp1 Sncb Mt2 Mt1 Mt4 Mt3 Mtf1 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway Tnfrsf13c Tnfrsf12a Birc3 Lta Birc2 Ltb Ltbr Traf3 Cd40lg Traf2 Tnfsf13b Tnfsf11 Map3k14 Tnfsf14 Tnfsf12 Tnfrsf11a ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 96%2473224 Antagonism of Activin by Follistatin Fst Fstl3 Inhba Inhbb GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prkaca Prkar2b Itpr3 Itpr2 Itpr1 Gng10 Kcng2 Akap5 Gng3 Gng2 Prkar1a Gng4 Gng7 Gng8 Prkacb Kcnb1 Prkar2a Kcns3 Gngt1 Gngt2 Kcnc2 Adcy8 Adcy5 Adcy6 Gcg Gnb2 Rapgef4 Gnb1 Rapgef3 Gnb4 Gnb3 Rap1a Gnb5 Gng11 Gng12 Prkar1b Gng13 Glp1r Iqgap1 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination Ube2g2 Ube2g1 H2bc9 H2bc7 H2bc8 Usp9x Prkdc H2bc3 Cdc73 Rtf1 Rnf181 Shprh Tmem129 Leo1 Ube2c Skic8 Selenos Pex2 Ube2j2 Rnf152 Rnf40 Ube2d1 Pex14 Ube2w Uchl3 Rnf144a Pex13 Ube2k Ube2e1 Pex12 Derl1 Hltf H2bu2 Ube2l3 Pex10 Wac Ube2h Ctr9 Paf1 Ube2a Vcp H2-Q10 Usp5 Rnf20 Ube2d3 Ube2z Ubc Bcl10 Ube2t Ube2n Ube2v2 Uba6 Cdc34 Usp7 Ube2e3 Rraga H2bc14 H2bc21 Uba1 Ube2b Rad18 Pcna Ube2q2 Otulin Hist1h2bp Ube2r2 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 96%9662360 Sensory processing of sound by inner hair cells of the cochlea Cacnb2 Cacna1d Capzb Lrrc52 Capza1 Capza2 Bsn Syp Rab3a Dnajc5 Otof Cabp2 Slc17a8 Pclo Cask Twf1 Myo3a Myo3b Fscn2 Xirp2 Grxcr2 Eps8 Grxcr1 Kcnq4 Myo7a Pls1 Pcdh15 Tmc1 Espnl Ush1g Tmc2 Cib2 Lhfpl5 Myo1c Whrn Twf2 Clic5 Sptan1 Epb41l3 Tmie Strc Cdh23 Ush1c Ezr Pjvk Eps8l2 Espn Myo15a Tprn Ripor2 Rdx Msn Kcnmb1 Kcnma1 Sptbn1 Snap25 Vamp2 Stx1a Myh9 Syn1 Cacna2d2 Atp2b1 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 96%1566948 Elastic fibre formation Fbln5 Itgb5 Bmp2 Tgfb1 Fbn1 Itga5 Efemp2 Itgb3 Efemp1 Fbn2 Tgfb2 Vtn Mfap4 Bmp10 Mfap5 Mfap2 Itga8 Mfap3 Tgfb3 Ltbp3 Ltbp2 Ltbp4 Ltbp1 Itgb8 Itgb6 Bmp7 Bmp4 Lox Loxl2 Itgav Loxl1 Itgb1 Loxl4 Loxl3 Furin Gdf5 Eln Fbln1 Fbln2 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 96%448424 Interleukin-17 signaling Il25 Il17c Mapk9 Mapk7 Mapk8 Ikbkb Jun Elk1 Ikbkg Map3k7 Map3k8 Nfkb1 Skp1 Fbxw11 Btrc Ubc Mapk1 Mapk3 Rps6ka3 Irak1 Mapkapk3 Rps6ka2 Traf6 Mapkapk2 Cul1 Ube2n Map2k7 Mapk14 Chuk Map2k6 Ppp2cb Ppp2ca Ube2v1 Map2k4 Tab3 Map2k3 Tab2 Tab1 Mapk10 Map2k1 Mapk11 Ripk2 Rps6ka5 Atf2 Rps6ka1 Vrk3 Il17rb Ppp2r1b Il17re Ppp2r1a Tnip2 Nod2 Nod1 Il17rc Dusp3 Il17ra Dusp4 Dusp7 Dusp6 Irak2 Mef2a Il17f Il17a Fos Ppp2r5d Mef2c RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%R-HSA-110328.4 Recognition and association of DNA glycosylase with site containing an affected pyrimidine H2bc14 H2bc9 H2bc7 H2ac20 H2bc8 Tinf2 H2bc3 H2bc21 H2bc26 H2ab2 H3c8 Neil2 Neil3 Nthl1 H2bu2 Ogg1 H2ac12 Neil1 H2ac11 Mbd4 Smug1 Acd H2ac15 H2ax Terf2ip Terf2 Hist1h2bp Terf1 Hist2h2aa1 H2aj Pot1 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559586 DNA Damage Telomere Stress Induced Senescence H2bc9 H2bc7 H2bc8 Atm Tinf2 H2bc3 H1f2 H1f3 Hira H2ab2 H3c8 Cabin1 Lmnb1 H2bu2 Ccne1 Ccne2 Acd H1-1 H1-0 Rb1 Asf1a Terf2ip H1-5 H1-4 Cdk2 Hmga2 Ccna1 Ccna2 Terf2 Cdkn1a Terf1 Hist2h2aa1 Ep400 Cdkn1b Pot1 Ubn1 Trp53 H2bc14 H2ac20 H2bc21 H2bc26 Kat5 Nbn H2ac12 H2ac11 Hmga1 H2ac15 H2ax Hist1h2bp H2aj Mre11a Rad50 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants Kit WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 96%3238698 WNT ligand biogenesis and trafficking Wnt8b Wnt8a Wnt16 Wnt11 Porcn Wnt6 Vps35 Vps29 Wls Wnt7b Vps26a Wnt3a Tmed5 Wnt7a Wnt2 Wnt1 Wnt4 Wnt3 Snx3 Wnt5a Wnt9a Wnt2b Wnt9b Wnt5b Wnt10a Wnt10b RET SIGNALING%REACTOME DATABASE ID RELEASE 96%8853659 RET signaling Frs2 Prkaca Dok4 Dok5 Dok6 Pspn Irs2 Grb10 Shank3 Nrtn Gab1 Mapk7 Plcg1 Prkca Sos1 Ptpn11 Gab2 Ret Prkacb Gdnf Rap1gap Gfra1 Grb7 Pik3cb Pik3cd Artn Shc3 Gfra2 Pik3ca Gfra3 Shc1 Gfra4 Pik3r1 Pik3r2 Dok1 Dok2 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) Alox12 Hpgd Ltc4s Alox5 Alox5ap Ptgr1 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling Insr Ppp2r5e Pip5k1b Tgfa Pip5k1a Flt3l Pip5k1c Irak1 Esr2 Traf6 Nrg2 Nrg4 Nrg3 Esr1 Akt1 Strn Kit Il1rl1 Cd28 Erbb2 Rac1 Vav1 Pik3r5 Pik3r6 Pik3r1 Pik3r2 Il33 Pip4k2b Pip4k2a Rac2 Trat1 Pdgfrb Ereg Pik3ap1 Hbegf Ntrk3 Btc Epgn Cd86 Cd80 Src Nrg1 Pik3cg Pik3cb Pik3cd Hgf Egfr Met Pik3ca Mapk1 Mapk3 Ier3 Flt3 Klb Ppp2cb Frs2 Fgf16 Ppp2ca Fgf15 Irs1 Fgf18 Irs2 Lck Fgf2 Fgf1 Bdnf Fgf4 Gab1 Fgf10 Fgf3 Fgf6 Ntf4 Fgf7 Ntrk2 Fgf9 Fgf20 Ntf3 Gab2 Ptpn11 Fgf23 Fyn Egf Fgfr4 Myd88 Fgf22 Areg Rhog Pdgfb Ppp2r1b Ppp2r1a Irak4 Pdgfra Ppp2r5d Ppp2r5c Ppp2r5b Cd19 Ins2 Ppp2r5a TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes Trp73 Ndrg1 Trp53 Apaf1 Cradd Pidd1 Trp53bp2 Atm Bcl2l14 Tmem219 Steap3 Aifm2 Trp63 Trp53inp1 Bnip3l Chm Bid Triap1 Prelid1 Bcl6 Tnfrsf10b Prelid3a Birc5 Rabggta Rabggtb Nlrc4 Igfbp3 Casp1 Ppp1r13b Casp6 Casp2 Bax Fas Crebbp Perp PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 Frs2 Fgf2 Fgf1 Gab1 Fgf4 Fgf10 Fgf3 Fgf6 Fgf9 Fgf20 Ptpn11 Pik3ca Fgf23 Fgf22 Pik3r1 DISEASE%REACTOME%R-HSA-1643685.19 Disease Csf2rb2 Csf2ra Ap2m1 Amn Prkacb Ap2a2 Ap2a1 Hdlbp Ap2b1 Ap2s1 Abca1 P4hb Cubn Idh1 Chsy1 Nhlrc1 Chst14 Galt Omd Hspg2 Sdc4 Sdc3 Sdc2 Gns Ppp1r3c B4galt7 B4gat1 B4galt1 Ext2 Ext1 Sdc1 Gbe1 Cyp11a1 Khk Gys1 Gys2 Gaa Chst3 Chst5 Pcx Aldob Gpc1 EG433182 Gpc3 Gpc2 Gpc5 Gpc4 Fmod Gpc6 Slc17a5 Tbxas1 Epm2a Papss2 Papss1 Naglu Kera Slc37a4 Agrn Gyg1 Abca4 B3galt6 Gckr Slc26a2 Galk1 Hk1 Alg9 Alg8 G6pc3 Alg6 Alg3 Ogn Alg2 Alg1 Mpdu1 Rft1 Dpagt1 Slc2a1 Pgm1 Cyp21a1 Cyp11b2 Tkfc Taldo1 Rpia Gale B3gat3 Galm Prelp Galns Lum Sgsh Dcxr Traf3 Ticam1 Cd14 Ikbke Flt3l Hnrnpu Mta1 Mta3 Aprt Pnp Ada Abcg8 Abcg5 Parp14 Parp16 Galnt1 Parp4 Parp6 Gsk3a Parp8 Parp10 Parp9 Prkg2 Maoa Hip1 Alk Eml4 Bcl11a Ppm1b Prkar1a Eif2ak3 Strn Birc6 Neil3 Nthl1 Ogg1 Neil1 Vps36 Ubap1 Tsg101 Mvb12a Mvb12b Vps37a Myo18a Vps37b Cux1 Vps37c Fgfr1op2 Vta1 Cpsf6 Vps37d Snf8 Vps25 Chmp5 Vps28 Vps4a Vps4b Tufm Trat1 Pdgfrb Pik3ap1 Ntrk3 Ttr Kif5b Csnk1a1 Opn1sw Cd209a Rab7 Rhog Erbin Itgb1 Dock1 Dock2 Elmo2 Cyfip1 Ppp1ca Ppp1cb Pmm2 Mpi Ptk2 Abca3 Cxcr4 Dag1 Ppfibp1 Nrp1 Pabpc1 Nck1 Myo9b Prkar2a Srd5a3 Dhdds Mcl1 Slc35a1 Dpm1 Dpm2 Dpm3 Il22b Ctsa Gne Dolk Gfpt1 Neu1 Nus1 Slc35c1 Havcr1 Ace2 Tmprss2 Elk1 Ereg Hbegf Btc Epgn Sqstm1 Arf1 Hspa8 Ahcy Mtrr Mtr Comt Mat1a Klb Fgf16 Fgf15 Irs1 Fgf18 Irs2 Fgf2 Pik3c3 Fgf1 Fgf4 Fgf10 Fgf3 Fgf6 Fgf7 Fgf9 Fgf20 Gab2 Fgf23 Fgfr4 Fgf22 Tlr9 Pik3r4 Abcc2 Il6ra Rnf213 Ube2l6 Atg7 Keap1 Lmo7 Cyp27a1 Ubr4 Cyp7b1 Tcn2 Uba5 Uba6 Uba7 Dusp10 Dusp9 Dusp8 Uba1 Uba3 Cul5 Vhl Rbp4 Rbp1 Hgf Crb3 Patj Pals1 Rdh12 Gss Ctbp1 Ctbp2 Brk1 Noxa1 Baiap2 Lrat Nckap1l Bcr Nckap1 Wasf2 Wasf1 Noxo1 Cyba Abi2 Abi1 Nox1 Prim2 Prim1 C1qbp Pola2 Pola1 Dnmt3a Dnmt3b Dnmt1 Pdgfra Slc2a2 Slc5a1 Slc6a3 Psen1 Psen2 Ncstn Aph1b Heyl Stra6 Hes5 Slc22a18 Elmo1 Hck Cd8b1 Upk1a Epcam Adora2b Entpd1 Nt5e Entpd5 C3ar1 Ggt1 Prkx Plcg2 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Btk Dpep1 Dpep2 Dvl1 Dvl2 Rlbp1 Dvl3 Myo5a Ggt5 Arpc3 Arpc2 Nlrp3 Pstpip1 Cyfip2 Arpc5 Arpc4 Ctsg Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Gnaz Fcgr1 Adcy9 Fcgr3 Fcgr4 Syk Mefv Fgr Myh2 Gnai2 Gnai1 Gnai3 Myo1c Nckipsd Prkar1b Was Wasf3 Pycard Gnat3 Prkar2b Cysltr2 Cysltr1 Wasl Sugt1 P2rx7 P2rx4 Myo10 Tnks2 Tnks Trim27 Lig1 Cd9 Nrg1 Ripk2 Myd88 Slc24a1 Tlr5 Nod2 Nod1 Irak4 Dusp7 Dusp6 Irak2 Mprip Ap3b1 Kiaa1549 Tent4a Akap9 Snd1 Lmna Trak1 Agtrap Trim24 Fam114a2 Fxr1 Kdm7a Zc3hav1 Clcn6 Agk Aggf1 Qki Fam131b Exoc1 Dkk1 Dkk2 Dkk4 Rnf43 Tubb5 Kremen2 Kremen1 Lrp6 Lrp5 Klc1 Gbf1 Trip11 Cep43 Golga4 Gcc2 Cog1 Gp9 Gp1bb Gp5 Xrn1 Stat5a Stat5b Pim1 Nox4 Grb2 Cyp2u1 Cyp1b1 Atic Kdm1a Ddx5 Kank1 Fkbp4 Slc35d1 Ugt1a5 Ugt1a1 Msn Sptbn1 Fgfr2 Acat1 Rps6kb2 Fen1 Shoc2 Mras Eif4a2 Eif4a1 Sftpb H2ac21 H2ac25 Hist1h2af H2ac1 Unc93b1 Tlr8 Tlr7 Tlr3 C1qa C1s2 Mbl2 Cgas Sting1 Irf7 Psma4 Dhx9 Ikbkb Psma3 Psma6 Psma5 Xrcc6 Psma2 Xrcc5 Psma1 Ikbkg Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Tfg Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rela Sec31a Btrc Psma7 F5 Psmc6 F8 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Nfkbib Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Cul1 Chuk Nr3c1 Esr1 Cyp19a1 Hdac4 Ube2i Kat5 Exo1 Nbn Rfc5 Rfc3 Rfc4 Rfc2 Hus1 Atrip Brip1 Dna2 Rad51c Rad51d Blm Rad51b Rad9a Bard1 Rad9b Top3a Wrn Mre11a Palb2 Rad51 Rad50 Rpa1 Topbp1 Rpa2 Rad17 Rbbp8 Brca2 Brca1 Rad51ap1 Xrcc2 Rpa3 Rad1 Atm Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Stam2 Sh3gl3 Src Sh3kbp1 Stam Ctnnb1 Eps15 Cbll1 Cbl Abcd1 Hgs Ctnnd1 Fip1l1 Cdh1 Sh3gl1 Etv6 Sh3gl2 Bin2 Kdr Met Shc1 Mapk1 Braf Mapk3 Ywhab Rap1a Mapk14 Frs2 Map2k2 Nras Map2k1 Sos1 Crk Hras Slc25a15 Arg1 Nags Asl Cps1 Nmral1 Ass1 Otc Ncor1 Ep300 Lig4 Tbl1x Hmox1 Xrcc4 Hdac3 Xpo1 Tbl1xr1 Hba-a1 Hbbt1 Med1 Nfe2l2 Ly96 Crebbp Apoa1 Tlr4 Fkbp1a Sap30l Ppia Suds3 Brms1 Rcor1 Jak3 Sap30 Tyk2 Sap18b Cast Blnk Prdx2 App Arid4b Jun Crbn Golga2 Arid4a Cd79a Prdx1 Cd79b Capn1 Capn2 Ifnar1 Hmg20b Sod2 Cdk5r1 Ifngr2 Ifngr1 Bcl2l11 Ywhae S1pr1 Sigmar1 Cdk5 Fasl Fnta Capns1 Fntb Stat2 Capns2 Il1r1 Cdc25c Sympk Foxo3 Lmnb1 Cstf1 Cdc25b Papola Clp1 Cdc25a Nudt21 Slc5a7 Cpsf1 Cstf2 Cpsf2 Cstf3 Cpsf3 Cstf2t Wdr33 Notch1 Rbx1 Ihh Shh Wnt5a Gng10 Dhh Sftpc Fgfr1 Slc12a1 Gng3 Gng2 Slc12a3 Slc12a6 Gng4 Gng7 Wnt3a Gng8 Casp9 Bad Gngt1 Gngt2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd8 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Sftpa1 Gng12 Gng13 Spred1 Spred3 Spred2 Nf1 Cul3 Hexa Hexb Cdc73 Idua Rtf1 Ncan Bgn Cspg5 Leo1 Cspg4 Dcn Skic8 Bcan Vcan Glb1 Pcca Mmaa Pccb Ids Hyal1 Mmut Arsb Gusb Ccne1 Ctr9 Ccne2 Paf1 Mmab Atrx Fzr1 Mmadhc Mmachc Tfdp2 Tfdp1 Tyro3 Skp2 Mapre3 Rb1 Ccnd2 Mrc1 Emc4 Ccnd3 Timd4 Ccnd1 Cldn1 Cdk6 Mertk Cdk4 Rnasek Cdk2 E2f1 Cd300a Axl E2f2 E2f3 Hspa5 Pros1 Cdkn1a Daxx Ly6e Gas6 Cdkn1b Cdkn1c Flt3 Cyp4f39 Cyp24a1 Nup37 Nup160 Ppp2cb Ppp2ca Clip1 Nup43 Btd Cd320 Ranbp2 Cblif Irf4 Dync1li2 Dync1li1 Nup107 Dynll1 Dynll2 Rps27 Ppp2r1b Hlcs Ppp2r1a Dync1h1 Nup85 Dync1i2 Dync1i1 Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Sec13 Ano10 Ano8 Ano7 Ppp1cc Ano6 Taok1 Ano5 Ano4 Ano2 Ano1 Cyp2r1 Ppp2r5e Nup133 Msh6 Msh2 Msh3 Pms2 Mlh1 Avpr2 Avpr1b Avpr1a Avp Tjp1 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Nmt2 Gtf2f2 Nrg2 Gtf2h4 Nrg4 Gtf2f1 Nrg3 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Rnmt Ercc3 Cdk7 Rngtt Fdx1 Fdxr Fdx2 H2ac20 Bcl2a1d Myc Akt3 Akt2 Akt1 Erlin2 Erlin1 Rpn2 Rpn1 Tcf7l2 Lyn Mov10 Yes1 Cftr H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 Ezh2 H2ax Csnk2a2 Rcc1 Ranbp1 Suz12 Cd28 Nmt1 Nfkb2 Ccr5 Ash2l Rac1 Hist1h2bp Jak1 Vav1 H2aj Os9 Pik3r5 Pik3r6 Pik3r1 Pik3r2 Cd3g Sel1l Magt1 Pak2 Brd4 H2bc9 H2bc7 H2bc8 H2bc3 Mib2 Rac2 S100a9 S100a8 Stat3 Echs1 Tmem258 Stat1 Rictor H2ab2 Rnf185 Derl3 Nek2 Derl2 Proc Derl1 Ifih1 H2bu2 Sike1 Cd86 Rnf135 Cd80 Trim25 Stt3a Mavs Stt3b Rigi Srpk1 Srpk2 Vcp Cx3cr1 Rab5a Ostc Rab5c Rab5b Pik3cg Pik3cb Igf1r Pik3cd Pik3ca Tusc3 Rhag Slc4a1 Hist2h2aa1 Erlec1 Prr5 Dad1 Hhat Ywhag Pdpk1 Dpy30 Wdr5 Ddost Csnk2b Eed Gsk3b Lck Mlst8 H2bc14 Ptpn6 Pdcd1 Rnf5 Mtor Cd4 Ptpn11 Fyn Csk H2bc21 Tnrc6c H2bc26 Rbbp5 Rbbp4 Rbbp7 Mapkap1 Ell Nelfa Nelfb Nelfe Taf15 Ctdp1 Taf11 Taf13 Taf12 Ccnk Tbp Taf4b Gtf2a1 Gtf2a2 Gtf2b Gtf2e1 Gtf2e2 Taf9 Ncbp2 Ncbp1 Supt4h1a Tcea1 Nelfcd Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Taf8 Eloa Taf7 Tpm3 Taf6 Eloc Taf5 Taf4 Taf3 Taf2 Taf1 Gja1 Ptpn12 Galnt3 Muc15 Muc13 Pomgnt1 Galnt12 Adamts1 Adamts5 Adamts4 Adamts3 Adamts2 Adamts8 Adamts7 Adamts6 Sema5a Sema5b C1galt1 Thsd1 Actb Thbs2 C1galt1c1 Thsd4 Adamts13 Adamts14 Adamts15 Large1 Adamts16 Cfp Adamts18 Adamts19 Spon2 Muc1 Spon1 Adamts10 Sbspon Adamts12 B3glct Muc4 Muc6 Cyp11b1 Thsd7a Cyp27b1 Muc20 Adamtsl1 Adamtsl2 Adamtsl3 Adamtsl4 Adamtsl5 Pomt1 Adamts20 Thsd7b Lfng Pomt2 Trp53 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Kpna1 Aaas Nup214 Banf1 Nup210 Nup155 Nup153 Slc25a5 Psip1 F2 Slc25a4 Hmga1 Rps14 Rpl4 Rps16 Rps18 Rps19 Eif2ak2 Rpsa Rpl37 Rpl39 Rps10 Kpnb1 Rps11 Rpl7 Hsp90aa1 Ipo5 Rpl32 Rps9 Rps7 Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Mlkl Grsf1 Tgfb1 Rps25 Rps26 Kpna4 Kpna7 Rps21 Kpna3 Cpsf4 Rpl39l Isg15 Rps15a Dnajc3 Clta Parp1 Cltc Calr Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Hspa1a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Canx Rps3 Rps4x Pabpn1 Ran Alg14 Zap70 Hibch Cyp17a1 Mccc1 Auh Ivd Mccc2 Ppm1k Fasn Amer1 Tpst1 Tpst2 Rnps1 Srsf1 Hgsnat F9 Napepld Srsf9 Cdc40 Ggcx Srsf7 Srsf6 Srsf3 Cars1 Srsf2 Srsf11 Srrm1 F10 Alyref Dhx38 U2af1l4 Elavl1 Eif4a3 Serping1 Clu Cd19 Fn1 Vtn Ap1m2 Ap1m1 Pacs1 Ap1s3 Ap1s2 Ap1b1 Ap1s1 Ap1g1 B2m H2-Q10 H2bc18 Map1lc3b Becn1 Uvrag Iscu Slc2a9 Traf6 Ube2n Ube2v1 Tab3 Tab2 Tab1 Mark3 Ywhah Hdac1 Acot2 Kit Ywhaz Nos2 Pomc Il17rc Il17ra Phf5a Vps39 Hyou1 Crnkl1 Med9 Vps18 Vps11 Vps16 Btf3 Cdk19 Med13l Cav1 Dnajb11 Map1b Xab2 Aup1 Ipo7 Hnrnpa2b1 Zcrb1 Prpf19 Bag2 Slc5a5 P4ha1 Vav3 Fmo3 P4ha2 P4ha3 Tpmt Puf60 Impdh1 Hnrnpul1 Vps41 Cd209d Vps45 Hprt1 Bcas2 Vav2 Gpkow Smndc1 Aqr Pcbp2 Pcbp1 Grpel1 Hnrnpr Clint1 Nmi Sugp1 Hnrnpd Hnrnpf Hnrnpk Ccar1 Hnrnpl Hnrnpm Tlr1 Tlr6 Tlr2 Arih1 Rbmx Sftpd Actg1 Hnrnph2 Hnrnph1 Cwc22 Sec11c Sec11a Hsp90ab1 Cwc27 Cpsf7 Hnrnpc Cwc25 Cwc15 Cbx1 Cdc37 Coro1a Rbm5 Rock2 Vps33a Vps33b Rock1 Txnl4a Vim Oas2 Ltf Dusp16 Gbp2 Gbp3 Rrbp1 Snrnp200 U2surp Gbp9 Snrpb2 Tomm70 Snrpa1 Furin Ptbp1 Kdelr1 Med22 Tgfbr1 Med21 Tgfbr2 Med28 Rptor Med29 Med11 Med19 Med18 Eif4g1 Atl2 Sf3a1 Sf3a2 Sf3a3 Pgk1 Dnajc10 Bcap31 Akt1s1 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Sf3b5 Sf3b6 Nlrp12 Ctnnbl1 Rcan3 Srrt Tsc2 Snrnp40 Eftud2 H2-M5 Eif4e H2-M3 Snrpn G3bp1 Acy1 G3bp2 Stx1b Cherp Sv2c Fus Syt2 Snap25 Chmp1a Sv2b Isy1 Cdc5l Syt1 Sv2a Plrg1 Vamp1 Hnrnpa3 Vamp2 Ppil6 Stx1a Ppil4 Apc Cebpd Slc34a1 Ppil3 Slc34a3 H2-Q1 Hnrnpa1 Slc34a2 Hnrnpa0 Ppil1 Nherf4 Prcc Cnbp Rbm10 Elavl2 Sar1b Bst2 Ufd1 Sec23a Dhx16 Dhx15 Nploc4 Retreg1 Scap Srrm2 Spcs3 Acaca Spcs1 Spcs2 Il17f Il17a Pex19 Prpf6 Pdia3 Sec24d Ppig Sec24c Ppih Ppie Ppib Sec24b Prpf8 Wbp11 Rtn3 Sec24a Pqbp1 Sp1 Clec5a Dnajc8 Ddx3x Sfpq Sun2 Larp1 Rbm22 Mmp9 Rbm17 Porcn Ddx46 Ddx42 Dnaja2 Eif4g2 Wdcp Eif4g3 Il18 Cd2bp2 Ddx23 Eif4e3 Chmp2a Tradd Traf2 Chmp3 Chmp7 Chmp6 Fadd Gzmb Itch Ripk3 Chmp4c Chmp4b Casp8 Casp4 Casp1 Ripk1 Gsdme Pdcd6ip Gsdmd Il1a Il1b Slc22a5 S100a1 Cd36 Tirap Wdr48 Atp1a2 Fxyd4 Atp1a1 Fxyd1 Atp1a3 Fxyd7 Fxyd6 Camk2g Camk2d Ahcyl1 Camk2b Camk2a Gclc Gclm Atp1b1 Atp1b3 Atp1b2 Prkaca Kcnj11 Abcc9 Itpr3 Itpr2 Itpr1 Mapk9 Mapk8 Cdkn2a Txn Il6 Mdm2 Zmym2 Ifnb1 Map2k7 Cebpb Map2k4 Bdnf Gab1 Plcg1 Frs3 Ntf4 Ntrk2 Ntf3 Egf Bcl2l1 Areg Eef1g Eef2 Dll4 Jag2 Jag1 Adam10 Neurl1b Adam17 Neurl1a Dll1 Mib1 Gemin7 Gemin4 Gemin5 Snrpb Smn1 Snrpd2 Snrpd1 Snrpd3 Gemin2 Ddx20 Abcc8 C3 C4a Gucy2c Sis Lct Slc35a3 Slc1a1 Slc3a1 Slc1a3 Slc3a2 Slc6a19 Slc7a7 Slc6a14 Slc36a2 Slc7a9 Slc6a20a Ganab Mgat5 Zdhhc9 Man2a1 Zdhhc11 Mgat2 Mgat1 Mogs Golga7 Edem2 Fut8 St6galnac3 St6galnac4 Fgfr3 St6galnac2 St3gal4 Syvn1 Mgat4c Mgat4a St3gal2 Mgat4b St3gal1 Man1b1 Zdhhc20 Prkcsh St6gal1 Zdhhc8 Zdhhc5 Zdhhc3 Zdhhc2 Camk4 Rhbdf2 Il10 Cd163 Plk2 Myh9 Erbb2 Txnip Med8 Med4 Med6 Axin1 Gatad2a Junb Gatad2b Tal1 Gps2 Mc2r Kat2b Kat2a Opn1mw Itga4 Abl1 Cdk8 Sin3a Pml Havcr2 Slc17a8 Pah Nedd4l Irak1 Esr2 Ybx1 Bag4 Itga2b F12 Klkb1 Trim28 Hes1 Oplah Twist1 Maml1 Maml2 Hdac11 Hdac10 Sfn Rbpj Med23 Med24 Med25 Med20 Hey2 Hey1 Med26 Med27 Med12 Med13 Med14 Med10 Med15 Med16 Med17 Ncor2 Mbd3 Mamld1 Egfr Med30 Med31 G6pc1 Kmt2d Il10ra Hdac2 Hdac5 Hdac7 Hdac6 Hdac9 Hdac8 Nrbp1 Pdgfb Pten Ccnc Thbs1 Prmt1 Foxo4 Gp1ba Foxo1 Tgfa Nr4a1 Npm1 Gck Golgb1 Smad2 Smad3 Smad4 Alg11 Txnrd1 Dctn1 Notch4 Chd3 Chd4 Notch2 Notch3 Rest Kras Mta2 Abcb6 Abcb4 Bsg Slc4a4 Slc33a1 Abcc6 Slc26a4 Slc26a3 Slco2a1 Brap Phb1 Lmbrd1 Slc27a4 Apbb1ip Arrb2 Slc39a4 Iqgap1 Slc6a2 Arrb1 Slc6a5 Slc2a10 Jak2 Fgb Slc16a1 Fga Slc35a2 Slco1b2 Rap1b Ksr1 Slc24a5 Vwf Abca12 Cnksr2 Slc20a2 Cnksr1 Slc24a4 Fgg Abcd4 Araf Slc22a12 Slc29a3 Itgb3 Abcb11 Pebp1 Raf1 Tln1 Map3k11 Vcl Slc40a1 Cp Slc11a2 Heph Prf1 Atp6v1h Foxm1 Zc3hc1 Icos Tbk1 Zbp1 Irf3 Slc9a9 Slc9a6 Bckdhb Bckdk Bckdha Dbt Cyp26b1 Dld Cyp26c1 Rdh5 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960519 CASP4-mediated substrate cleavage Gsdmd Il1b Casp3 Casp4 Il18 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME%R-HSA-8853884.3 Transcriptional Regulation by VENTX Trp53 Lef1 Csf1r Anapc5 Anapc4 Cdkn2a Anapc1 Tnrc6c Anapc2 Anapc11 Ube2c Ehmt2 Anapc10 Anapc7 Tnrc6a Ehmt1 Nfkb1 Tnrc6b Cdc27 Ube2d1 Cdc16 Tcf7l2 Anapc16 Il6 Ube2e1 Cdc23 Mov10 Anapc15 Ago4 Rela Ago3 Fzr1 Ctnnb1 Ago1 Ccnd1 Cebpb CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 96%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) Cyp51a1 Dhcr7 Sc5d Lbr Tm7sf2 Hsd17b7 Nsdhl Dhcr24 Ebp Msmo1 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%71064 Lysine catabolism Dhtkd1 Crym Hykk Pipox Dlst Aadat Dld Slc25a21 Gcdh Phykpl Aldh7a1 Aass REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 96%9769739 Regulation of clotting cascade Ano6 Ano5 F2r Vwf Proz Serpina10 F7 F9 Kng2 App Gp1ba Procr Serpina5 Serpine2 Smpd1 Gpc1 Cd177 Thbd Gpc3 Prtn3 Gpc2 F12 Klkb1 Hspg2 Gpc5 Sdc4 Sdc3 Gpc4 Sdc2 Gpc6 F10 Proc Serpind1 Serpinc1 Adamts13 F2 F3 Serping1 F5 F8 Sdc1 Pf4 Serpine1 Pros1 Agrn Gp9 Gp1bb Gp5 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9656256 Defective OGG1 Substrate Processing Ogg1 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME DATABASE ID RELEASE 96%9634815 Transcriptional Regulation by NPAS4 Nr3c1 Bdnf Kcnip3 Syt10 Tnrc6c Cdk5r1 Ret Cdk5 Tnrc6a Tnrc6b Npas4 Srf Arnt Mov10 Bmal1 Ago4 Ago3 Nampt Ago2 Ago1 Xpo1 Plk2 Rest Iqsec3 Mdm2 Rbfox3 Mapk1 Mapk3 Fos Gem Crebbp Ins2 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication Ssbp1 Mgme1 Polg Polg2 Top3a Twnk Polrmt Rnaseh1 Exog COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation Pcolce Col4a1 Col24a1 P3h2 Col5a1 Colgalt1 P3h1 Col25a1 P3h3 Col4a2 Col9a2 Pcolce2 Mmp13 Col9a3 Crtap Ctsl Mmp9 Colgalt2 Col6a6 Serpinh1 Col8a1 Col6a3 Plod3 Col4a5 Plod1 Col9a1 Plod2 Col8a2 Col4a6 Col20a1 Adamts3 Adamts2 Lamb3 Lama3 Mmp3 Lamc2 Adamts14 Lox Loxl2 Loxl1 Loxl4 Loxl3 Bmp1 Tll2 Tll1 P4hb Mmp20 Pxdn Plec Itga6 Cd151 Itgb4 Col15a1 Col16a1 Col17a1 Col18a1 Col11a1 Col12a1 Col11a2 Col13a1 Ctsb Col14a1 Ctss Col19a1 Col10a1 Col2a1 Col26a1 Col3a1 Col1a2 Col27a1 Col28a1 Col1a1 Col22a1 Col6a1 Col5a2 Col4a3 Ppib Col23a1 Col7a1 Col6a2 P4ha1 Col5a3 P4ha2 Mmp7 Col4a4 P4ha3 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 96%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Chrnd Chrne Chrng Chrna3 Chrnb4 Chrnb2 Chrna4 MET ACTIVATES RAP1 AND RAC1%REACTOME%R-HSA-8875555.2 MET activates RAP1 and RAC1 Rac1 Rap1b Crkl Gab1 Rap1a Rapgef1 Dock7 Crk Hgf Met FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%5661270 Formation of xylulose-5-phosphate Sord Dcxr Akr1a1 Cryl1 Xylb RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 96%8935964 RUNX1 regulates expression of components of tight junctions Cldn5 Tjp1 Cbfb TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 96%8878166 Transcriptional regulation by RUNX2 Psma4 Psma3 Psma6 Psma5 Psma2 Esrra Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Smurf1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Satb2 Rbx1 Psma7 Psmc6 Psmc5 Ppargc1b Ihh Psmc2 Psmc1 Psmc4 Psmc3 Stub1 Ubc Psmd7 Psmd6 Bax Msx2 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Nr3c1 Smad1 Bmp2 Smad4 Esr1 Ar Smad6 Hdac4 Sox9 Akt3 Akt2 Akt1 Hes1 Rbm14 Yes1 Nkx3-2 Twist2 Twist1 Itgbl1 Lgals3 Yap1 Hey2 Hey1 Mmp13 Stat1 Cdk1 Gli3 Ucma Gli2 Src Skp2 Rb1 Cbfb Ccnd1 Cdk4 Maf Wwtr1 Mapk1 Cdkn1a Dlx5 Wwp1 Mapk3 Sp7 Gsk3b Itga5 Hivep3 Hdac6 Abl1 Hdac3 Ppm1d Hand2 Znf521 Col1a1 Ppargc1a IRS ACTIVATION%REACTOME DATABASE ID RELEASE 96%74713 IRS activation Irs1 Insr Irs2 Grb10 Ins2 REGULATION OF NF-KAPPA B SIGNALING%REACTOME DATABASE ID RELEASE 96%9758274 Regulation of NF-kappa B signaling Trp53 Casp8 N4bp1 Ikbkb Nlrx1 Ubc Usp14 Usp18 Ikbkg Traf2 Lrrc14 Traf6 Ikbip Chuk CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-HSA-446353.3 Cell-extracellular matrix interactions Rsu1 Vasp Tesk1 Actn1 Parvb Fermt2 Parva Pxn Lims2 Flnc Fblim1 Ilk Itgb1 Arhgef6 Flna ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 96%379397 Enzymatic degradation of dopamine by COMT Maoa Comt Tomt FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC Tubb6 Tubb3 Tubb1 Tcp1 Tuba4a Cct6b Cct6a Tubb4b Tuba1b Tubb4a Tuba1a Tuba1c Tubal3 Tuba8 Cct3 Cct2 Tubb2b Tuba3b Tubb2a Cct8 Cct7 Cct5 Cct4 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 96%3371378 Regulation by c-FLIP Tradd Traf2 Fas Fasl Casp8 Tnfsf10 Ripk1 Tnfrsf10b Fadd FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190371 FGFR3b ligand binding and activation Fgf18 Fgf1 Fgf9 Fgf20 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 96%9705462 Inactivation of CSF3 (G-CSF) signaling Jak2 Csf3r Tyk2 Stat5a Stat5b Ube2d3 Ubc Csf3 Stat3 Syk Jak1 Stat1 Cul5 Hck Socs3 Socs1 Ube2d1 Lyn Eloc Rnf7 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway Ctss H2-M5 H2-Q1 H2-M3 B2m H2-Q10 Ctsl Lnpep PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis Cad Dhodh Umps ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%8874177 ATF6B (ATF6-beta) activates chaperones Hspa5 Atf6b Mbtps1 Mbtps2 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 96%75892 Platelet Adhesion to exposed collagen Adamts13 Gp6 Fcer1g Vwf Itga10 Gp1ba Fyn Itgb1 Gp9 Gp1bb Gp5 Itga1 Lyn Itga2 REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 96%9861718 Regulation of pyruvate metabolism Pdp1 Pdp2 Ranbp9 Pdpr Gid4 Maea Ldha Gid8 Armc8 Dlat Rmnd5a Rmnd5b Sirt4 Gstz1 Dld Ubc Pdhx Wdr26 Pdha1 Pdha2 Me1 Pdk4 Nek1 Pdk3 Mkln1 Pdk2 Pdk1 Pdhb INTERLEUKIN-1 PROCESSING%REACTOME%R-HSA-448706.3 Interleukin-1 processing Nfkb2 Gsdmd Il1a Il1b Rela Ctsg Nfkb1 Casp1 Il18 KINESINS%REACTOME DATABASE ID RELEASE 96%983189 Kinesins Kif18b Kif26b Kifc2 Kif12 Kif2a Kif21a Kif1c Kif2b Kif21b Kif2c Kif13b Kif1a Kif1b Kif6 Kif9 Kif27 Kif16b Kif20b Kif19a Racgap1 Cenpe Kif26a Kif11 Kif15 Kif22 Kif23 Kif18a Kif20a Klc1 Klc4 Klc3 Klc2 Kif3a Kif3b Kif3c Kifap3 Kif5b Kif4 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME%R-HSA-168330.5 Viral RNP Complexes in the Host Cell Nucleus Hspa1a METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351202 Metabolism of polyamines Srm Nqo1 Paox Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Oaz1 Psmb6 Oaz3 Psmb1 Oaz2 Psmb3 Psmb2 Agmat Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Odc1 Psmc3 Psmd7 Psmd6 Sat1 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Azin2 Azin1 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME%R-HSA-5619104.4 Defective SLC12A1 causes Bartter syndrome 1 (BS1) Slc12a1 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%446203 Asparagine N-linked glycosylation Kdelr2 Stx5 Capzb Ykt6 Capza1 Capza2 Copz2 Copz1 Arf5 Golga2 Asgr2 Asgr1 Chst10 Alg10b Tmem115 Spta1 Sptb Tmed9 Gmppa Pmm2 Mpi Gmppb Pmm1 Tmed3 Copg1 Copg2 Ank3 Ank1 Copb2 Sptan1 Copb1 Sptbn1 Sptbn2 Manea Sptbn4 B4galt4 B4galt5 B4galt6 Amdhd2 Gnpnat1 Srd5a3 Pgm3 St6galnac5 Cmas B4galt1 Dhdds B4galt2 Nudt14 Alg5 B4galt3 Slc35a1 Dolpp1 Fuom Dpm1 Dpm2 Dpm3 Gmds St6gal2 Renbp Ctsa Gne St8sia6 St8sia4 St8sia5 Uap1 Dolk Npl Neu2 Neu3 Neu4 Nagk Fcsk Gfpt1 Gfpt2 Neu1 Dhrsx St6galnac1 Nus1 Slc35c1 St3gal5 Nanp Nsf Fpgt Gfus St8sia2 Nans St8sia3 St8sia1 Gria1 Calr Glb1 Rad23b Slc17a5 Arf1 Arfgap2 Canx Ctsz Alg14 St6galnac6 Mgat3 Dync1li2 Dync1li1 Hk1 Alg9 Alg8 Alg6 Areg Alg3 Alg2 Alg1 Dynll1 Dynll2 Mpdu1 Rft1 Dpagt1 Dync1h1 Man1a Man1a2 Man1c1 Dync1i2 Dync1i1 B4galnt2 Sec13 Arfgap1 St3gal6 Actr1a Mia3 Dctn2 Dctn3 Tgfa Ctsc Scfd1 Ppp6r1 Ppp6r3 Lman2 Sec22c Sec22b Sec22a Tfg Preb Trappc6b Ppp6c Trappc9 Trappc6a Trappc5 Trappc4 Sec31b Trappc3 Sec31a Trappc2 Trappc1 F5 F8 Rab1a Stx17 Psmc1 Rab1b Trappc2l Gosr2 Ubc Lman1l Tbc1d20 Cd59b Uso1 Sec23ip Trappc10 Sec16b Sec16a Mcfd2 Lman2l Serpina1d Cnih1 Gorasp1 Golgb1 Cnih3 Cnih2 Folr1 Ankrd28 Ganab Bet1 Mgat5 Man2a1 Mgat2 Mgat1 Mogs Arf4 Edem2 Fut8 St6galnac3 St6galnac4 St6galnac2 Syvn1 St3gal4 Alg11 Mgat4c Mgat4a St3gal2 Mgat4b St3gal1 Man1b1 Prkcsh Edem1 Actr10 Dctn5 St6gal1 Dctn6 Dctn1 Dctn4 Rpn2 Rpn1 Capza3 Kdelr3 Rnf103 Csnk1d Amfr Rnf139 Marchf6 Trim13 Uggt1 Uggt2 Edem3 Os9 Cga Gbf1 Sel1l Magt1 Fuca1 Tmem258 Rnf185 Chst8 Derl2 Derl1 Arcn1 Lhb Stt3a Stt3b Vcp Ostc Bet1l Tusc3 Cog1 Kdelr1 Cog2 Dad1 Cog3 Cog4 Cog6 Cog7 Cog8 Ddost Napa Napb Napg Rnf5 Umod Mlec Engase Lman1 Copa Arfgap3 Arf3 Sar1b Sec23a Cope Ngly1 Gosr1 Mvd Ubxn1 Pdia3 Sec24d Sec24c Ins2 Col7a1 Sec24b Sec24a INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling Jak2 Stat3 Jak1 Il6ra Stat1 Socs3 Cbl Il6st Tyk2 Il6 Ptpn11 SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL Lefty1 Nodal Acvr1c Drap1 Dand5 Smad2 Foxh1 Acvr1b Smad3 Acvr2b Smad4 Cer1 Mapk1 Mapk3 Furin Acvr2a Pcsk6 Lefty2 Foxo3 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation H2bu2 H2ac12 H2ac11 Dnmt3a H2ac15 Dnmt3l Dnmt3b H3c7 H2bc14 Dnmt1 H2ax H2bc9 H2bc7 H2ac20 H2bc8 H2bc3 H2bc21 Hist1h2bp H2bc26 Hist2h2aa1 H2aj H2ab2 Uhrf1 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111461 Cytochrome c-mediated apoptotic response Diablo Mapk1 Apaf1 Mapk3 Apip Xiap Casp3 Casp7 Aven Uaca Casp9 REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 96%877312 Regulation of IFNG signaling Jak2 Ptpn1 Ifngr2 Jak1 Pias1 Ifngr1 Socs3 Ifng Socs1 Ptpn6 Ptpn11 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) Slc1a3 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 96%5654221 Phospholipase C-mediated cascade; FGFR2 Fgf16 Fgf18 Fgf2 Fgf1 Fgf4 Plcg1 Fgf10 Fgf3 Fgf6 Fgf7 Fgf9 Fgf20 Fgf23 Fgf22 CHD1 AND CHD2 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943411 CHD1 and CHD2 subfamily Puf60 Smndc1 Rbm17 Ddx46 Ddx42 H2bc9 Myog H2bc7 Myod1 H2bc8 H2bc3 Cdc73 Rtf1 Leo1 Tcf4 Skic8 H2ab2 H2bu2 Chd1 Ctr9 Paf1 Tcf12 U2surp Snrpb2 Snrpa1 Hist2h2aa1 Chd2 Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Sf3b5 H2bc14 Sf3b6 H2ac20 Tcf3 Snrpn H2bc21 H2bc26 Cherp H2ac12 H2ac11 Snrpb H2ac15 H3c7 Phf5a H2ax Snrpd2 Snrpd1 Dhx15 Snrpd3 Hist1h2bp Supt16 H2aj Ssrp1 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling Erbb2 Grb7 Nrg1 Nrg2 DNA DAMAGE REVERSAL%REACTOME%R-HSA-73942.4 DNA Damage Reversal Alkbh5 Fto Alkbh3 Ascc1 Ascc3 Ascc2 Mgmt Alkbh2 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME%R-HSA-389977.4 Post-chaperonin tubulin folding pathway Tubb6 Tubb3 Tubb1 Tuba4a Tubb4b Tuba1b Tubb4a Tuba1a Tbcd Arl2 Tbcc Tuba1c Tbcb Tubal3 Tbca Tuba8 Tubb2b Tbce Tuba3b Tubb2a REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 96%5686938 Regulation of TLR by endogenous ligand Tlr4 Fgb Fga Fgg S100a1 Gsdme Gsdmd Lbp Cd36 S100a9 S100a8 Tlr7 Tlr1 Cd14 Tlr6 Tlr2 Ly96 Apob EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells Mpo Lpo ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 96%1592389 Activation of Matrix Metalloproteinases Mmp11 Mmp15 Mmp17 Ctrb1 Ctsk Mmp13 Ctsl Mmp9 Mmp10 Plg Mmp14 Mmp16 Timp1 Timp2 Klkb1 Cma1 Tpsb2 Mmp8 Mmp3 Spock3 Elane Ctsg Col18a1 Mmp1a Prss2 Furin Mmp2 Mmp24 Mmp25 Mmp7 INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion Ace2 Ano7 Ano6 Tmprss2 Ano5 Ano4 Ano2 Ano1 Furin Ano10 Ano8 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654710 PI-3K cascade:FGFR3 Fgf16 Frs2 Fgf18 Fgf2 Fgf1 Gab1 Fgf4 Fgf9 Fgf20 Ptpn11 Pik3ca Fgf23 Pik3r1 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 96%110312 Translesion synthesis by REV1 Pcna Rfc4 Rpa2 Rfc1 Rfc2 Rpa3 Ubc Mad2l2 Rev1 Rev3l Rfc5 Rfc3 Rpa1 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) Avp Avpr2 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade Pde6g Prkca Pde6a Pde6b Gucy2e Slc24a1 Grk1 Sag Rho Gnat1 Cnga1 Fnta Gucy2f Fntb Camkmt Gngt1 Metap1 Metap2 Rcvrn Nmt1 Rgs9bp Ppef1 Gnb1 Guca1b Nmt2 Guca1a Prkcq APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%180689 APOBEC3G mediated resistance to HIV-1 infection Psip1 Hmga1 Ppia Banf1 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 96%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate Idh1 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 96%111459 Activation of caspases through apoptosome-mediated cleavage Apaf1 Xiap Casp3 Casp7 Casp9 EGFR DOWNREGULATION%REACTOME%R-HSA-182971.8 EGFR downregulation Ptpn12 Egf Tgfa Ereg Hbegf Areg Arhgef7 Btc Epgn Epn1 Spry2 Stam2 Sh3gl3 Eps15l1 Sh3kbp1 Stam Eps15 Cbl Hgs Sh3gl1 Sh3gl2 Ubc Egfr Ptprk Spry1 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 96%8985586 SLIT2:ROBO1 increases RHOA activity Slit2 Robo1 Myo9b Rhoa VLDL CLEARANCE%REACTOME%R-HSA-8964046.2 VLDL clearance Apoc1 Apobr Vldlr Apoc4 Lsr Apob CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE Itgb3bp Net1 Arhgef10l Vav2 Prex1 Trio Mcf2 Mapk8 Tiam2 Arhgef15 Arhgef19 Ngef Arhgef9 Bcl2l11 Arhgef7 Ywhae Arhgef6 Ngfr Bex3 Arhgef4 Sqstm1 Gna13 Fgd2 Rasgrf2 Fgd1 Fgd4 Arhgef37 Fgd3 Arhgef39 Arhgef38 Arhgef40 Plekhg5 Plekhg2 Casp3 Ubc Aatf Traf6 Ngf Tiam1 Sos1 Abr Arhgef18 Sos2 Mcf2l Arhgef16 Bad Arhgef17 Arhgef11 Arhgef10 Arhgef26 Psen1 Itsn1 Psen2 Ncstn Rac1 Akap13 Aph1b Casp2 Kalrn Vav1 Arhgef3 Arhgef2 Arhgef1 Maged1 Ect2 Vav3 COMPLEX I BIOGENESIS%REACTOME%R-HSA-6799198.5 Complex I biogenesis Ndufv2 Ndufv1 Ndufv3 Ndufc1 Ndufc2 Ndufs1 Ndufs2 Ndufs5 Ndufs7 Ndufs8 Foxred1 Ndufa1 Ndufa3 Ndufa2 Ndufa7 Ndufa6 Ndufa9 Ndufa8 Ndufab1 Ndufb2 Ndufb3 Hscb Ndufb6 Ndufb5 Ndufb7 Ndufb9 Oxa1l mt-Nd4 mt-Nd5 mt-Nd6 mt-Nd1 mt-Nd2 mt-Nd3 Hspa9 Nubpl Ecsit Sfxn4 Ndufa12 Ndufa10 Timmdc1 Ndufa13 Ndufb11 Ndufb10 Lyrm2 Dmac2 Dmac1 Ndufaf7 Ndufaf6 Ndufaf5 Tmem186 Ndufaf4 Ndufaf8 Ndufaf3 Ndufaf2 Ndufaf1 Ndufb8 Tmem126b Tmem126a Acad9 Ndufa5 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 96%9927020 Heme assimilation Hbbt1 Hba-a1 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) Hyal1 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family Fcer1g Clec10a Clec4n Clec4a2 Clec4d Clec4e Muc1 Clec4b2 Muc15 Muc13 Plcg2 Muc4 Fyn Muc6 Muc20 Syk Lyn PINK1-PRKN MEDIATED MITOPHAGY%REACTOME%R-HSA-5205685.9 PINK1-PRKN Mediated Mitophagy Ube2v1 Map1lc3a Atg5 Atg12 Atg9a Tbk1 Tomm22 Prkn Sqstm1 Optn Ube2l3 Tomm40 Mfn1 Mfn2 Mterf3 Vdac2 Ube2d3 Pink1 Tomm6 Ubc Vdac3 Tomm7 Tomm70 Map1lc3b Vdac1 Ube2n RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%73762 RNA Polymerase I Transcription Initiation Gtf2h3 Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Hdac2 Hdac1 Gatad2a Gatad2b Rbbp4 Ehmt2 Rbbp7 Polr1c Mbd3 Polr1d Chd3 Chd4 Rrn3 Mta1 Ercc6 Mta3 Tbp Ttf1 Polr1b Polr1a Kat2b Polr1g Mta2 Polr1e Polr1h Kat2a Taf1d Polr2h Taf1a Polr2e Taf1c Polr2f Taf1b Polr2k Mnat1 Ubtf Gtf2h2 Gtf2h1 Gtf2h4 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation Yes1 Hey2 Satb2 Hey1 Src Hdac3 Rb1 Cbfb Ar Znf521 Wwtr1 Maf Mapk1 Hdac6 Mapk3 Col1a1 Sp7 Abl1 Hes1 Ucma Gli3 Yap1 PRIMITIVE STREAK FORMATION%REACTOME%R-HSA-9754189.5 Primitive streak formation Smad2 Foxh1 Ctnnb1 Tcf7 Smad3 Lef1 Smad4 Sox2 Bmp4 Pou5f1 Tbpl2 Mixl1 Eomes Trim33 T Gsc SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease Pik3ca Frs2 Fgfr4 Nras Gab1 Plcg1 Pik3r1 Sos1 Hras NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins Dlg3 Dlg4 Cask Syt9 Grm1 Lin7a Grm5 Lin7b Lin7c Stxbp1 Homer1 Homer2 Begain Homer3 Sipa1l1 Dlgap1 Apba2 Apba1 Apba3 Dlgap4 Dlgap3 Nrxn1 Nrxn2 Epb41l2 Epb41l3 Epb41l5 Syt7 Shank1 Shank3 Syt12 Sharpin Pdlim5 Epb41 Syt10 Dbnl Lrrtm1 Lrrtm2 Lrrtm3 Grin2b Nlgn2 Nlgn1 Nlgn3 Syt2 Syt1 Grin2a Stx1a Dlg2 Grin1 Grin2d Grin2c TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 96%420029 Tight junction interactions Pard6a Pard3 F11r Prkci Pard6b Cldn23 Cldn6 Cldn3 Cldn4 Cldn9 Cldn20 Cldn22 Cldn7 Cldn8 Pard6g Cldn12 Cldn15 Cldn14 Cldn11 Cldn10 Cldn1 Cldn17 Crb3 Cldn16 Cldn19 Patj Pals1 Cldn18 Cldn5 Cldn2 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME DATABASE ID RELEASE 96%450531 Regulation of mRNA stability by proteins that bind AU-rich elements Dcp1a Tnpo1 Xrn1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Hspa1a Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Zfp36l1 Hspa8 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Ywhab Psmd2 Psmd1 Adrm1 Sem1 Mapkapk2 Eif4g1 Mapk14 Prkca Pabpc1 Mapk11 Akt1 Hspb1 Nup214 Ywhaz Tnfsf13 Anp32a Prkcd Elavl1 Xpo1 Exosc9 Exosc8 Exosc5 Dis3 Exosc4 Exosc7 Exosc6 Zfp36 Parn Exosc1 Exosc3 Exosc2 Dcp2 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 96%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Bad Bcl2 Stat3 Bcl2l1 Bcl2l11 Bmf Bid LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME%R-HSA-9723907.3 Loss of Function of TP53 in Cancer Trp53 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9026357 NTF4 activates NTRK2 (TRKB) signaling Ntf4 Ntrk2 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Pik3ca Epo Jak2 Epor Irs2 Gab1 Pik3r5 Pik3cg Pik3r1 Pik3cb Pik3cd Lyn FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis Cd3g Elmo2 Vav2 Cyfip1 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Btk Actg1 Actb Myo5a Arpc3 Arpc2 Cyfip2 Arpc5 Arpc4 Mapk1 Fcgr4 Syk Ptk2 Mapk3 Fgr Myh2 Brk1 Myo1c Nckipsd Was Wasf3 Baiap2 Nckap1l Wasl Myo10 Crk Nckap1 Nck1 Fyn Wasf2 Wasf1 Abl1 Abi2 Myo9b Abi1 Lyn Yes1 Myh9 Rac1 Vav1 Elmo1 Hck Vav3 Dock1 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 96%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) Trmt5 Tyw2 Lcmt2 Tyw3 Tyw5 Tyw1 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS Epo Jak2 Shc1 Epor Irs2 Crkl Vav1 Nras Rapgef1 Sos1 Hras Lyn DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 Amn Cblif Cubn DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 96%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) Slc20a2 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Polb Apex1 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation Ppp2cb Ppp1cc Jak2 Ppp2ca Shoc2 Mras Map2k2 Ksr1 Nras Map2k1 Araf Mark3 Ppp2r5e Raf1 Hras Map3k11 Ppp1cb Ppp2r1b Ppp2r1a Src Camk2g Camk2d Camk2b Camk2a Braf Ppp2r5d Ywhab Ppp2r5c Ppp2r5b Brap Ppp2r5a Phb1 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764260 Regulation of Expression and Function of Type II Classical Cadherins Sp1 Jup Cdh19 Angptl4 Tnrc6c Tnrc6a Tnrc6b Mov10 Ago4 Ago3 Ago2 Ctnnb1 Ago1 Sox10 Zeb2 Ctnnd1 Hoxc8 Cdh8 Heyl Adam19 Adam33 Cdh24 Ctnna1 Snai1 Prdm8 Ilf3 Foxf1 Zc3h12a Bhlhe22 Cdh11 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME%R-HSA-9652282.4 Drug-mediated inhibition of ERBB2 signaling Erbb2 Cdc37 Erbin Hsp90aa1 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 96%111463 SMAC (DIABLO) binds to IAPs Diablo Apaf1 Xiap Casp3 Casp7 Casp9 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020956 Interleukin-27 signaling Jak2 Canx Stat3 Il27 Jak1 Stat1 Il27ra Crlf1 Il6st Tyk2 Ebi3 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 96%5083636 Defective GALNT12 causes CRCS1 Muc6 Galnt12 Muc20 Muc1 Muc15 Muc13 Muc4 DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions Clec5a Lck Vav2 Nras Plcg1 Sos1 Grap2 Hras Cd300lb Plcg2 Fyn Klrk1 Btk H2-Q1 Cd300e Tyrobp B2m Klrd1 Trem2 Siglec15 Pik3cb Pik3ca Lcp2 Rac1 Syk Trem1 Pik3r1 Pik3r2 Vav3 Sirpb1b ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding Izumo4 Acr Izumo2 Izumo1 Cd9 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 96%480985 Synthesis of dolichyl-phosphate-glucose Nudt14 Alg5 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8866423 VLDL assembly Apoc1 Mttp Apoc4 P4hb Apob ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders Kcnj11 Abcc9 Sel1l Abca12 Abcd4 Psma4 Abcb11 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Rnf185 Derl3 Psmb5 Psmb4 Derl2 Psmb7 Derl1 Psmb6 Psmb1 Psmb3 Psmb2 Vcp Psma7 Psmc6 Abcd1 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Erlec1 Psmd3 Abca1 Abca3 Psmd2 Psmd1 Abcg8 Adrm1 Abcg5 Sem1 Rnf5 Erlin2 Abcc2 Erlin1 Cftr Abcb6 Abcb4 Abcc8 Os9 Abcc6 Apoa1 Lmbrd1 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170968 Frs2-mediated activation Frs2 Ngf Mapk1 Map2k2 Braf Mapk3 Crkl Ywhab Rap1a Map2k1 Rapgef1 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8941855 RUNX3 regulates CDKN1A transcription Runx3 Trp53 Cdkn1a Smad3 Tgfb1 Smad4 Zfhx3 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint Gsk3b Csnk1e Csnk1a1 Nek11 Psma4 Plk3 Psma3 Mapk11 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Chek2 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Cdc25a Psmb1 Psmb3 Psmb2 Fbxw11 Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Chek1 Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Mapk14 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013148 CDC42 GTPase cycle Arhgap32 Ykt6 Pak4 Prex1 Arhgap35 Trio Mcf2 Plekhg3 Ktn1 Srgap1 Srgap2 Srgap3 Wipf3 Tmpo Arhgap39 Wipf2 Wipf1 Dock7 Was Wasl Pak6 Myo9b Pak5 Cdc42bpa Cdc42bpb Fnbp1 Dock8 Arhgef11 Fnbp1l Cpne8 Arhgef10 Scrib Iqgap3 Fmnl3 Daam1 Cav1 Arhgef25 Stom Pik3r1 Pik3r2 Ect2 Vav3 Iqgap1 Jup Pak1 Stard8 Vav2 Pak3 Dlc1 Pak2 Stard13 Wdr91 Arhgef15 Wdr81 Arhgef19 Map3k11 Ngef Arhgap4 Arap1 Arhgef9 Arhgap9 Arhgef7 Gmip Arhgef6 Arhgef4 Gna13 Def6 Rasgrf2 Fgd2 Fgd1 Fgd4 Fgd3 Arfgap2 Plekhg2 Arhgap22 Arhgap20 Arhgap24 Arhgap29 Arhgap33 Arhgap31 Sh3pxd2a Arhgap30 Dock11 Plekhg4 Plekhg1 Ralbp1 Arhgap40 Arhgap44 Arhgap45 Tfrc Git1 Baiap2 Arhgap17 Fam13b Shkbp1 Tiam1 Bcr Farp1 Kctd3 Lamtor1 Arap3 Pard6a Cdc42ep2 Arap2 Cdc42ep5 Cdc42ep3 Arhgap26 Cdc42ep4 Syde1 Abr Dnmbp Steap3 Git2 Spata13 Dock10 Racgap1 Snap23 Mcf2l Rab7 Dock6 Arhgdib Arhgdia Arhgef16 Arhgap42 Fmnl2 Arhgdig Fmnl1 Arfgap3 Cdc42se2 Iqgap2 Lbr Diaph3 Cdc42ep1 Depdc1b Vamp3 Arhgef26 Itsn1 Arhgap5 Arhgap1 Arhgap10 Arhgap21 Vangl1 Ophn1 Pld1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer Sp1 Ybx1 Smad2 Tgif1 Smad3 Tgif2 Smad4 Rnf111 Usp9x Hdac1 Smad7 Myc Ncor2 Cdkn2b Parp1 Junb Rbl1 Ncor1 Smurf2 Ube2d1 Ep300 Cdk8 Trim33 Ski Tfdp2 Tfdp1 Ccnk E2f4 E2f5 Ube2d3 Skil Ubc Wwtr1 Serpine1 Mapk1 Nedd4l Mapk3 Furin Col1a2 Cdk9 Atp1b4 Ccnt2 Ccnc Ccnt1 Ppm1a Men1 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%194002 Glucocorticoid biosynthesis Cyp11b1 Hsd3b6 Cyp21a1 Hsd3b1 Pomc Cyp11b2 Serpina6 Cyp17a1 Hsd11b1 Hsd11b2 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription Gli1 Gli3 Gli2 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 96%170822 Regulation of Glucokinase by Glucokinase Regulatory Protein Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Nup85 Gck Nup37 Sec13 Nup160 Gckr DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination Actl6a Polb Suds3 Birc3 Birc2 Traf2 Prkn Actb Cdc25a Nlrp3 Vcpip1 Uchl5 Usp15 Snx3 Usp8 Ripk1 Vdac2 Vdac3 Vdac1 Ogt Trp53 Rnf146 Tnks2 Tnks Otud3 Usp13 Usp33 Wdr48 Usp10 Mul1 Rce1 Il33 Ddb2 Tgfb1 Nfrkb Usp9x Ino80e Tfpt Ino80d Ino80c Ino80b Actr5 Actr8 Ruvbl1 Rad23a Rad23b Yy1 Ino80 Skp2 Mdm2 Mdm4 Ccna1 Ccna2 Mat2b Cdc20 Ripk2 Clspn Abraxas1 Brcc3 Babam1 Babam2 Uimc1 Tnip2 Nod2 Pten Nod1 H2ac21 H2ac25 Hist1h2af H2ac1 Usp14 Usp18 Rnf123 Siah2 Keap1 Psma4 Foxo4 Psma3 Psma6 Psma5 Psma2 Psma1 Ikbkg Traf3 Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Smurf2 Foxk2 Foxk1 Uchl3 Psmb5 Hcfc1 Psmb4 Psmb7 Senp8 Psmb6 Asxl1 Psmb1 Uchl1 Psmb3 Mbd6 Psmb2 Asxl2 Tada3 Trrap Psma7 Psmc6 Psmc5 H2bc18 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Becn1 Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Traf6 Ide Smad1 Smad2 Tab1 Smad3 Smad4 Esr1 H2ac20 Ar Smad7 Myc Kdm1b Hif1a Cftr H2ac12 H2ac11 H2ac15 Axin2 Hist1h2bp Bard1 Arrb2 Axin1 Gata3 Arrb1 Ccp110 Brca1 Usp30 H2bc9 H2bc7 H2bc8 Stambpl1 H2bc3 Otud7a Zranb1 Rhot1 Ptrh2 Cdk1 Abraxas2 Ube2d1 Wdr20 Ifih1 H2bu2 Rnf135 Stam2 Atxn7 Trim25 Mavs Rigi Stam Vcp Usp3 Usp5 Hgs Kat2b Tomm70 Kat2a Hist2h2aa1 Atxn3 Tgfbr1 Tgfbr2 Josd2 Usp2 Usp7 Yod1 Usp21 H2bc14 Rnf128 Adrb2 Usp4 Cyld Otud7b Rhoa Nedd8 Tnfaip3 Fkbp8 H2bc21 H2bc26 Ep300 Stambp Apc Otub1 Bap1 Usp44 Usp42 Usp49 Usp48 Ufd1 Usp47 Otub2 Usp37 Mysm1 Tnip3 Tnip1 Usp22 Usp20 Usp26 Usp25 Usp28 Otud5 Usp12 Usp16 Usp19 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events Prkaca Itpr3 Camkk1 Itpr2 Camkk2 Itpr1 Prkcg Prkx Gnal Prkacb Adcy3 Adcy4 Gna11 Adcy1 Gna15 Adcy2 Gna14 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Mapk1 Gnaq Gnai2 Gnai1 Gnai3 Prkar1b Gnat3 Prkar2b Plcb3 Plcb2 Plcb1 Prkca Prkar1a Plcb4 Camk4 Prkar2a Pla2g4a Grk2 Pde1b Pde1c Prkcd Pde1a Camk2g Camk2d Ahcyl1 Camk2b Camk2a MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953078 MPS II - Hunter syndrome (CS DS degradation) Ids FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 96%9830364 Formation of the nephric duct Gata3 Id4 Pcdh19 Mecom Fgf2 Ctnnb1 Emx2 Plac8 Osr1 Hoxb4 Pax2 Bmp4 Lhx1 Pax8 Wfdc2 Ret Hoxa6 Npnt SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4551638 SUMOylation of chromatin organization proteins Rnf2 Satb1 Nup43 Sumo3 Ranbp2 Nup93 Nup50 Nup35 Nup54 Hdac2 Hdac1 Pom121 Hdac4 Nup205 Ube2i Nup133 Nup188 Tpr Nup107 Rae1 Pias1 Ndc1 Nup42 Nup62 Pcgf2 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Ring1 Chd3 Cbx8 Phc2 Satb2 Phc1 Cbx4 Cbx2 Phc3 Nup85 Suz12 Bmi1 Cbx5 L3mbtl2 Nup37 Sec13 Nup160 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 96%5223345 Miscellaneous transport and binding events Ctns Mmgt1 Dmtn Magt1 Nipa1 Nipa2 Add2 Lrrc8e Add1 Lrrc8a Lrrc8b Lrrc8c Lrrc8d Pip Add3 Ank Tusc3 Rhag Nipal4 Nipal2 Rhcg Nipal3 Rhbg Nipal1 Mrs2 Azgp1 Slc66a1 AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9612973 Autophagy Mtmr3 Chmp2a Plin3 Ift88 Prkn Optn Chmp3 Chmp7 Chmp6 Ube2l3 Pcnt Mfn1 Gabarapl2 Chmp4c Mfn2 Chmp4b Ulk1 Vdac2 Ube2d3 Atg3 Gabarap Ubc Vdac3 Rb1cc1 Atg10 Atg13 Gabarapl1 Atg9b Map1lc3b Vdac1 Becn1 Atg101 Uvrag Ambra1 Wdr45b Wdr45 Atg16l2 Atg16l1 Wipi2 Atg4b Ube2n Atg4c Atg4a Atg4d Ube2v1 Hsf1 Prkaa1 Prkaa2 Tomm22 Cftr Lamp2 Tomm40 Cetn1 Plin2 Gfap Rnase1 Ubap1 Tsg101 Park7 Mvb12a Mvb12b Vps37a Vps37b Vps37c Csnk2a2 Wipi1 Vps37d Tomm6 Tomm7 Vps28 Hsp90aa1 Usp30 Pex5 Map1lc3a Fundc1 Atg5 Atg12 Atg9a Atm Nbr1 Sqstm1 Hsp90ab1 Vcp Prkag3 Prkag1 Prkag2 Hspa8 Tomm70 Rptor Epas1 Csnk2b Slc38a9 Lamtor5 Lamtor4 Rraga Pik3c3 Mlst8 Rragb Lamtor1 Rragc Lamtor2 Rragd Tsc2 Dync1li2 Mtor Tsc1 Dync1li1 Tbk1 Hdac6 Pik3r4 Arl13b Dynll1 Dynll2 Prkab2 Prkab1 Dync1h1 Mterf3 Pink1 Dync1i2 Hbbt1 Dync1i1 Atg7 Mtmr14 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 96%5654743 Signaling by FGFR4 Fgf16 Ppp2cb Frs2 Fgf15 Ppp2ca Fgf18 Fgf2 Fgf1 Nras Fgf4 Gab1 Plcg1 Frs3 Fgf6 Sos1 Fgf9 Hras Fgf20 Ptpn11 Fgf23 Fgfr4 Spry2 Ppp2r1a Mknk1 Cbl Ubc Pik3ca Mapk1 Braf Mapk3 Pik3r1 Klb CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357769 Caspase activation via extrinsic apoptotic signalling pathway Unc5a Tlr4 Dapk3 Appl1 Casp3 Casp8 Ripk1 Dcc Tradd Ticam2 Traf2 Fas Ticam1 Cd14 Fasl Ly96 Tnfsf10 Maged1 Dapk1 Unc5b Tnfrsf10b Casp9 Dapk2 Fadd MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) Glb1 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428643 Organic anion transport by SLC5 17 25 transporters Slc5a12 Slc5a8 Slc17a5 Slc25a10 Slc25a11 Slc25a1 GSD II%REACTOME%R-HSA-5357609.5 GSD II Gyg1 Gaa NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 Sp1 Chd6 Gsta3 Ccl12 Srxn1 Nqo1 Tkt Sod3 Psma4 Psma3 Psma6 Psma5 Prdx1 Psma2 Psma1 Cdkn2a Psmd12 Psmd11 Psmd14 Psmd13 Sqstm1 Nfkb1 Skp1 Txn Psmb5 Psmb4 Psmb7 Psmb6 Slc7a11 Psmb1 Psmb3 Psmb2 Rela Notch1 Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Abcg2 Psmd2 Psmd1 Abcc1 Adrm1 Pgd Sem1 Cul1 Idh1 Gsk3b Prkaa2 Egf Myc Bcl2 Txnrd1 Pdgfa Bcl2l1 Areg Ep300 Hmox1 G6pdx Abcc3 Atf4 Mafk Mafg Gclc Taldo1 Gclm Bach1 Me1 Abcf2 Nfe2l2 Crebbp Keap1 REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 96%912694 Regulation of IFNA IFNB signaling Usp18 Ifnar1 Ptpn1 Jak1 Ifnb1 Socs3 Socs1 Tyk2 Ptpn6 Stat2 Ptpn11 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 96%2129379 Molecules associated with elastic fibres Fbln5 Itgb5 Bmp2 Tgfb1 Efemp2 Itgb3 Efemp1 Tgfb2 Vtn Mfap4 Bmp10 Mfap5 Mfap2 Itga8 Mfap3 Tgfb3 Ltbp3 Ltbp2 Ltbp4 Ltbp1 Itgb8 Itgb6 Bmp7 Bmp4 Itgav Itgb1 Gdf5 Fbln1 Fbln2 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%71262 Carnitine synthesis Bbox1 Aldh9a1 Tmlhe Shmt1 PTEN LOSS OF FUNCTION IN CANCER%REACTOME DATABASE ID RELEASE 96%5674404 PTEN Loss of Function in Cancer Pten INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling Il1f10 Il1rapl1 Mapk8 Il1rl2 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5674499 Negative feedback regulation of MAPK pathway Mapk1 Map2k2 Braf Mapk3 Map2k1 Raf1 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination Nudt21 Cpsf7 Cpsf1 Cstf2 Cpsf2 Cstf3 Cpsf3 Pabpn1 Snrpb Cstf2t Wdr33 Fip1l1 Snrpd3 Cpsf4 Ncbp2 Zfp473 Ncbp1 Slbp Sympk Lsm10 Cstf1 Lsm11 Papola Clp1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190322.3 FGFR4 ligand binding and activation Fgf16 Fgf23 Fgf15 Fgfr4 Fgf18 Fgf2 Fgf1 Fgf4 Fgf6 Fgf9 Fgf20 Klb OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA Tet2 Tet1 Tet3 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764560 Regulation of CDH1 Gene Transcription Sp1 H2bc9 H2bc7 H2bc8 H2bc3 H2ab2 Kdm1a H2bu2 Zfp217 Rb1 Arid1a Tcf12 Kmt5a Zmym2 Mapk1 Hist2h2aa1 Mapk3 Ctbp1 Ctbp2 Foxq1 Wt1 Eed Tle1 Tgif2 Pkm H2bc14 Foxa2 H2ac20 Zeb1 Tcf3 Zbtb33 Klf9 Hdac2 Hdac1 Strap Mphosph8 Tfap2a Mcrip1 Foxj2 Foxp2 H2bc21 H2bc26 Rbbp4 Rbbp7 Smarca4 H2ac12 H2ac11 H2ac15 H3c7 Twist2 Ezh2 H2ax Zeb2 Twist1 Snai2 Suz12 Hist1h2bp H2aj Snai1 Klf4 Sirt1 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9024446 LXR-mediated signaling Apoe Nr1h2 Rxra Ncor2 Angptl3 Tnrc6c Plin1 Ncor1 Eepd1 Nr1h3 Kdm1a Tnrc6a Arl4c Tnrc6b Kdm1b Kdm3a Nrip1 Apod Ep300 Abcg1 Tbl1x Fabp6 Mov10 Mylip Ago4 Ago3 Hdac3 Ago2 Ago1 Kdm4a Scd1 Gps2 Ncoa1 Tbl1xr1 Apoc1 Apoc2 Abca1 Ugt1a2 Abcg8 Rxrb Abcg5 Apoc4 Fasn Pck1 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) Nqo1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Oaz1 Psmb6 Oaz3 Psmb1 Oaz2 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Odc1 Psmc3 Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Azin1 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) Lingo1 Omg Rtn4 Ngfr Mcf2 Arhgdia Rhoa Mag DISEASES OF THE NEURONAL SYSTEM%REACTOME%R-HSA-9675143.3 Diseases of the neuronal system Opn1sw Rdh12 Lrat Stra6 Ttr Abca4 Rdh5 Rlbp1 Rbp4 Napepld Opn1mw Rbp1 NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism Parp6 Naxe Parp8 Parp10 Parp9 Slc25a51 Nt5e Slc5a8 Naprt Nadk2 Nudt12 Nmrk2 Nmrk1 Nadsyn1 Cd38 Nadk Nmnat1 Nampt Slc22a13 Nmnat3 Nmnat2 Qprt Bst1 Nnmt Parp14 Parp16 Parp4 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME DATABASE ID RELEASE 96%9672387 Defective F8 accelerates dissociation of the A2 domain F8 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle Git1 Pak1 Pak4 Pak3 Itsn2 Pak2 Ptk2b Pard6a Usp9x Nck2 Srgap2 Wwp2 Nck1 Git2 Sptbn1 Arhgef7 Cltc Arhgef6 Myo6 Txnl1 Peak1 Stam2 Src Stam Depdc1b Hgs Wdr6 Epha2 Arhgap31 Arhgap30 Dlg5 Vangl1 Pik3r1 Pik3r2 Rhou Sptan1 Iqgap1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 96%77289 Mitochondrial Fatty Acid Beta-Oxidation Them4 Mcat Acad11 Acad10 Acot3 Acot9 Acadvl Acot7 Acot2 Echs1 Acsm3 Them5 Acads Hadh Ndufab1 Mcee Pcca Mmaa Acot11 Pccb Acot12 Acot13 Mmut Acaa2 Acbd6 Pctp Acbd7 Hadha Acsf2 Hadhb Dbi Acadl Mecr Eci1 Acadm Decr1 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling Ngf Casp2 Ywhae Ngfr Bex3 Casp3 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair Actl6a Polb Apex1 Xrcc1 Lig3 Rnf111 Fanci Fancc Kdm4b Actb Rbx1 Ube2t Trp53 Sprtn Pclaf Ddb1 Usp43 Wdr48 Mad2l2 Rev1 Ube2b Lig1 Usp1 Rev3l Cul4a Usp10 Rad18 Poli Cul4b Dtl Sirt6 Mdc1 Ercc6 Alkbh5 Fto Alkbh3 Ascc1 Ascc3 Ascc2 Ddb2 Mapk8 Nfrkb Tinf2 Usp45 Parp2 Ino80e Isg15 Tfpt Ino80d Ino80c Parp1 Ino80b Actr5 Actr8 Ruvbl1 Xpa H3c8 Xpc Rad23a Rad23b Cops3 Yy1 Cops6 Ercc1 Ercc4 Ercc5 Cops8 Chd1l Ino80 Acd Cops7a Cops7b Mpg Terf2ip Cdk2 Ccna1 Ccna2 Terf2 Terf1 Fen1 Pot1 Ppp4r2 Timeless Tipin Ppp4c Clspn Trp53bp1 Abraxas1 Brcc3 Rnf168 Nsd2 Rad52 Fancl Babam1 Fancm Babam2 Fanca Uimc1 Fancb Fance Fancf Fancg Ube2l6 Faap24 Faap20 Faap100 Cenps Prkdc Xrcc6 Xrcc5 Chek2 Msh6 Msh2 Msh3 Pms2 Mlh1 Uvssa Znf830 Ubc Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Sem1 Cenpx Gtf2h1 Ube2n Ube2v2 Gtf2h4 Dclre1a Uba7 Gtf2h3 Dclre1b Gtf2h5 Fan1 Poln Ercc2 Ccnh Sumo3 Ercc3 Cdk7 Pias3 H2ac20 Pias4 Ercc8 Parg Adprs Ube2i Pias1 Kat5 Exo1 Eme1 Mus81 Nbn Gen1 Rfc5 Pold2 Neil2 Pold1 Neil3 Rfc3 Nthl1 Pcna H2ac12 Ogg1 Rfc4 Pnkp Neil1 H2ac11 Fignl1 Mbd4 Rfc1 Rfc2 Smug1 Pold4 Pold3 Hus1 H2ac15 Atrip Brip1 Dna2 H2ax Pole3 Rad51c Rad51d Pole2 Blm Rad51b Chek1 Pole4 Hist1h2bp Rad9a Bard1 Rad9b Top3a Xab2 H2aj Slx4 Wrn Mre11a Herc2 Spidr Prpf19 Palb2 Mgmt Rad51 Rad50 Firrm Rpa1 Rnf4 Topbp1 Rpa2 Rad17 Rbbp8 Rtel1 Cetn2 Brca2 Brca1 Xrcc3 Aqr Rad51ap1 Xrcc2 H2bc9 Rpa3 H2bc7 Polk H2bc8 Rad1 Atm H2bc3 Polh Pole H2ab2 Cops4 Rchy1 Cops2 Alkbh2 H2bu2 Trim25 Vcp Cops5 Fancd2 Hist2h2aa1 Usp7 H2bc14 H2bc21 H2bc26 Abl1 Isy1 Rif1 Paxip1 Ell Lig4 Baz1b Nhej1 Tdp2 Tdp1 Xrcc4 Bap1 Ppp5c Apbb1 Kdm4a Smarca5 Polq Ufd1 Polm Dclre1c Eya2 Nploc4 Eya1 Eya4 Eya3 Ubxn1 Poll Tcea1 Ppie DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 96%5578997 Defective AHCY causes HMAHCHD Ahcy MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390648 Muscarinic acetylcholine receptors Chrm5 Chrm4 Chrm1 Chrm3 Chrm2 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 Apoe Dlg4 Stat5a Ereg Csn2 Gabrg2 Hbegf Gabrg3 Btc Stmn1 Adap1 Mxd4 Gabra1 Src Itch Wwox Nrg1 Egfr Ubc Pik3ca Shc1 Wwp1 Gabrq Gabrb1 Gabrb3 Gabrb2 Nrg2 Nrg4 Nrg3 Cxcl12 Tab2 Nras Esr1 Sos1 Hras Egf Pgr Ncor1 Adam17 Sparc Gfap S100b Nedd4 Psen1 Psen2 Ncstn Aph1b Pik3r1 Yap1 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Hadha Echs1 Hadhb Acadl Hadh NEUROTRANSMITTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%112311 Neurotransmitter clearance Maoa Bche Slc6a4 Ache Comt Tomt Slc22a2 Aldh2 Slc6a3 Slc22a1 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 96%3247509 Chromatin modifying enzymes Actl6a Actl6b Smarce1 Sap30l Suds3 Brms1 Rcor1 Sap30 Sap18b Arid4b Arid4a Pbrm1 Hmg20b Kdm1a Kdm4b Actb Arid2 Yeats4 Ogt Sap130 Kdm5b Brwd1 Suv39h1 Suv39h2 Smyd3 Setd3 Nsd3 Setd2 Kmt5c Setd7 Setdb2 Setd6 Setdb1 Nsd1 Aebp2 Mecom Prdm9 Dot1l Atf7ip Ash1l Hdac10 Ncor2 Ehmt2 Ruvbl1 Ehmt1 Mbd3 Kdm6b Arid1a Arid1b Ccnd1 Kmt5a Cdk4 Ep400 Riox2 Kmt2d Kmt2b Jmjd6 Hdac2 Smarcb1 Hdac8 Smarca2 Smarca4 Supt20 Nsd2 Vps72 Ing4 Ing3 Smarcd1 Kat7 Supt3 Smarcd2 Msl2 Msl3 Msl1 Hat1 Prmt5 Eny2 Smarcc2 H2ac21 Padi2 Jade1 Smarcc1 Coprs Jade2 H2ac25 Brd8 Hist1h2af Jade3 Morf4l2 Prmt7 Morf4l1 Prmt3 H2ac1 Supt7l Taf5l Mrgbp Wdr77 Taf6l Dmap1 Epc1 Elp2 Elp1 Elp4 Tada1 Elp3 Elp6 Elp5 Kdm7a Prmt6 Prmt1 Phf20 Nfkb1 Hcfc1 Kat8 Yeats2 Kat14 Dr1 Rela Mta1 Tada3 Trrap Tada2a Mta3 Prdm16 Zzz3 H2bc18 Mbip Kansl3 Kansl1 Kansl2 Sgf29 Kdm4c Padi3 Padi4 Padi1 Padi6 H2ac20 Hdac1 Meaf6 Pax3 Kat5 Kdm1b Kdm3a Chd3 Chd4 H2ac12 H2ac11 H2ac15 H3c7 Ezh2 H2ax Rest Suz12 Nfkb2 Ash2l Mta2 Hist1h2bp H2aj Jak2 H2bc9 H2bc7 H2bc8 H2bc3 Gatad2a Gatad2b Ruvbl2 H2ab2 Kdm5a Kdm6a Ing5 Phf2 H2bu2 Kdm4d Kdm2b Atxn7 Kdm5d Kdm2a Kdm3b Kdm5c Phf8 Arid5b Gps2 Kat2b Kat2a Kmt2c Hist2h2aa1 Smyd2 Dpy30 Wdr5 Eed H2bc14 Setd1b H2bc21 Setd1a H2bc26 Rbbp5 Rbbp4 Ncor1 Rbbp7 Atf2 Brpf3 Brpf1 Carm1 Kat6a Ep300 Tbl1x Clock Hdac3 Taf12 Dnmt3a Kdm4a Ncoa2 Ncoa1 Tbl1xr1 Smarcd3 Taf9 Usp22 Crebbp SENSORY PERCEPTION OF SOUR TASTE%REACTOME DATABASE ID RELEASE 96%9729555 Sensory perception of sour taste Otop1 Kcnj2 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins Lta4h Cyp1a2 Alox15 Cyp1a1 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358747.4 CTNNB1 S33 mutants aren't phosphorylated Ppp2cb Ppp2ca Gsk3b Ctnnb1 Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling Yes1 Socs6 Lck Cbl Prkca Ptpn6 Sos1 Fyn Sh2b2 Sh2b3 Socs1 Kit Lyn VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.5 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) Slc6a20a FANCONI ANEMIA PATHWAY%REACTOME%R-HSA-6783310.6 Fanconi Anemia Pathway Dclre1a Dclre1b Rpa2 Fan1 Poln Cenps Rpa3 Fanci Wdr48 Fancc Usp1 Eme1 Mus81 Ercc1 Fancl Ercc4 Fancm Fanca Fancb Fance Fancf Fancg Atrip Ubc Fancd2 Faap24 Faap20 Ube2t Slx4 Faap100 Cenpx Rpa1 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Cdc25a Psmb1 Psmb3 Ccne1 Psmb2 Ccne2 Tfdp2 Tfdp1 Skp2 Psma7 Psmc6 Rb1 Psmc5 Psmc2 Psmc1 Ccnd1 Psmc4 Psmc3 Cdk4 Ubc Cdk2 Ptk6 E2f1 Ccna1 Cks1b Psmd7 Ccna2 Cables1 Psmd6 Lin54 Max Cdkn1a Psmd8 Cdkn1b Lin9 Psmd3 Psmd2 Wee1 Mnat1 Psmd1 Lin37 Adrm1 Sem1 Cul1 Ccnh Cdk7 Myc Rbl2 Akt3 Akt2 Akt1 Rbbp4 E2f4 E2f5 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 96%9914274 3-methylglutaconic aciduria Auh DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 96%5578998 Defective OPLAH causes OPLAHD Oplah SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855191 Synthesis of IPs in the nucleus Ippk Ip6k2 Ip6k1 Ipmk DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid Pnliprp2 Pnliprp1 Pnlip Lipf Cel Clps SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-HSA-2142688.4 Synthesis of 5-eicosatetraenoic acids Ltc4s Alox5 Gpx4 Pon3 Alox5ap Pon1 Pon2 Gpx2 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173623 Classical antibody-mediated complement activation C1qc Crp C1qb C1qa C1rb C1s2 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species Nudt2 Sod3 Ccs Atox1 Prdx2 Nox4 Prdx1 Txnrd1 Sod2 Txn Cyba Cybb Cat Aqp8 Ero1a Gpx2 Prdx3 Prdx6 Ncf1 Ncf2 Txnrd2 Ncf4 Gpx3 Atp7a Txn2 Gpx6 Gpx5 Gpx8 P4hb Gpx7 G1 PHASE%REACTOME DATABASE ID RELEASE 96%69236 G1 Phase Ppp2cb Jak2 Ppp2ca Ccnh Cdk7 Rbl2 Cdkn2a Cdkn2b Cdkn2c Rbl1 Abl1 Skp1 Lyn Ppp2r1b Ppp2r1a Ccne1 Ccne2 Tfdp2 Tfdp1 Skp2 Rb1 Ccnd2 Ccnd3 E2f4 Ccnd1 E2f5 Cdk6 Cdk4 Ubc Cdk2 Ptk6 E2f1 Cks1b E2f2 E2f3 Ppp2r2a Cdkn1a Cdkn1b Cdkn1c Mnat1 Cul1 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME%R-HSA-5619048.3 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) Slc11a2 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 96%5579016 Defective UGT1A4 causes hyperbilirubinemia Ugt1a5 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 96%199418 Negative regulation of the PI3K AKT network Insr Ppp2r5e Pip5k1b Tgfa Pip5k1a Flt3l Pip5k1c Irak1 Esr2 Traf6 Nrg2 Nrg4 Nrg3 Esr1 Trib3 Akt3 Akt2 Akt1 Strn Kit Il1rl1 Cd28 Erbb2 Rac1 Vav1 Pik3r5 Pik3r6 Pik3r1 Pik3r2 Il33 Pip4k2b Pip4k2a Rac2 Trat1 Pdgfrb Ereg Pik3ap1 Hbegf Ntrk3 Btc Epgn Cd86 Cd80 Src Nrg1 Pik3cg Pik3cb Pik3cd Hgf Egfr Met Pik3ca Mapk1 Mapk3 Ier3 Phlpp1 Phlpp2 Flt3 Klb Ppp2cb Frs2 Fgf16 Ppp2ca Fgf15 Them4 Irs1 Fgf18 Irs2 Lck Fgf2 Fgf1 Bdnf Fgf4 Gab1 Fgf10 Fgf3 Fgf6 Ntf4 Fgf7 Ntrk2 Fgf9 Fgf20 Ntf3 Gab2 Ptpn11 Fgf23 Fyn Egf Fgfr4 Myd88 Fgf22 Areg Rhog Pdgfb Ppp2r1b Ppp2r1a Pten Irak4 Pdgfra Ppp2r5d Ppp2r5c Ppp2r5b Cd19 Ins2 Ppp2r5a DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Slc35a1 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 96%202427 Phosphorylation of CD3 and TCR zeta chains Cd3g Ptpn22 Csk Cd3e Cd3d Lck Ptprc Ptprj Pag1 H2-Eb1 Cd4 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Pik3ca Stat3 Stat1 Nras Pdgfra Pik3r1 Pik3cb Sos1 Pik3r2 Hras ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 96%9956514 ARG1 variants cause hyperargininemia Arg1 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.3 Expression of NOTCH2NL genes Elane HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation Blvra Slco1b2 Abcc2 Ugt1a5 Abcg2 Fabp1 Alb Ugt1a1 Abcc1 Hmox2 Blvrb Hmox1 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones Hsd17b1 Fdx1 Fdxr Fdx2 Cyp19a1 Hsd17b3 Hsd17b12 Hsd3b6 Cyp21a1 Lhb Srd5a3 Hsd3b1 Pomc Cyp11b2 Stard3nl Stard4 Stard3 Star Tspo Hsd17b11 Cyp11b1 Hsd17b14 Cyp11a1 Srd5a1 Srd5a2 Cyp17a1 Hsd17b2 Serpina6 Akr1b8 Hsd11b1 Hsd11b2 Akr1b1 Cga SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 96%9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste Gnat3 Tas2r40 Tas2r41 Itpr3 Scn3a Plcb2 Trpm4 Trpm5 Grm1 Scn4b Calhm1 Tas2r39 Tas2r119 Tas2r38 Grm4 Tas1r2 Tas1r1 Tas2r120 Tas1r3 Tas2r16 Tas2r13 Tas2r137 Scn9a Tas2r136 Tas2r140 Tas2r4 Scn1b Tas2r107 Tas2r7 Gnb1 Gnb3 Scn2a Scn2b Gng13 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer Hey2 Hey1 Mib2 Ncor2 Skp1 Mamld1 Notch1 Rbx1 Ubc Kat2b Kat2a Cul1 Hdac2 Hdac1 Hdac5 Hdac4 Myc Hdac7 Hdac6 Hdac9 Hdac8 Ncor1 Dll4 Hes1 Jag2 Jag1 Adam10 Ep300 Cdk8 Neurl1b Tbl1x Adam17 Neurl1a Dll1 Mib1 Hdac3 Tbl1xr1 Psen1 Psen2 Ncstn Maml1 Aph1b Maml2 Heyl Hdac11 Hdac10 Hes5 Rbpj Ccnc Crebbp DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER Rpa2 Aqr Rpa3 Polk Pole Xpa Ercc1 Ercc4 Ercc5 Uvssa Znf830 Rbx1 Polr2c Ubc Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2h4 Gtf2h3 Usp7 Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Ercc8 Ddb1 Isy1 Cul4a Cul4b Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Rfc1 Rfc2 Pold4 Pold3 Ercc6 Pole3 Pole2 Pole4 Tcea1 Xab2 Ppie Prpf19 Rpa1 REPRODUCTION%REACTOME DATABASE ID RELEASE 96%1474165 Reproduction Sun2 Smc1a Lmnb1 Mlh1 Cxcr4 Nanos3 Cbfa2t2 H2ac20 Ube2i Fkbp6 Nbn H2ac12 H2ac11 Fignl1 Prdm1 Prdm9 B4galt1 H2ac15 H3c7 H2ax Rad51c Bmp4 Adam2 Catsperd Blm Catsperb Catsperg1 Izumo4 Acr Ovgp1 Hist1h2bp Catsper4 Izumo2 Catsper2 Top3a Izumo1 H2aj Adam30 Hvcn1 Mre11a Catsper3 Catsper1 Adam21 Rad51 Cd9 Rad50 Firrm Zp1 Zp3 Rpa1 Zp2 Kcnu1 Rpa2 Rbbp8 Hyal5 Brca2 Brca1 H2bc9 Rpa3 H2bc7 H2bc8 Pou5f1 Atm Tinf2 H2bc3 H2ab2 H3c8 Psmc3ip Mnd1 Mlh3 Spo11 H2bu2 Msh4 Dmc1 Msh5 Acd Terf2ip Cdk4 Cdk2 Terf2 Terf1 Hist2h2aa1 Smc3 Pot1 Tet2 Pdpn H2bc14 Rad21 Tfap2c Syce2 Syce3 Syce1 Sun1 H2bc21 Tex12 Sycp1 H2bc26 Sycp2 Syne1 Syne2 Sycp3 Stag3 Rec8 Sox17 Smc1b Stag2 Stag1 Eomes Hspa2 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8941858 Regulation of RUNX3 expression and activity Tgfb1 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Cdkn2a Psmd12 Psmd11 Psmd14 Psmd13 Smurf2 Smurf1 Psmb5 Ep300 Psmb4 Psmb7 Psmb6 Runx3 Psmb1 Psmb3 Psmb2 Src Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Cbfb Psmc4 Psmc3 Mdm2 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 96%198745 Signalling to STAT3 Ngf Stat3 Ntrk1 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%2408557 Selenocysteine synthesis Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Eefsec Rps21 Sars1 Sepsecs Rpl39l Sephs2 Rps15a Secisbp2 Pstk Rps27l Rplp2 Rps27 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family Slc39a8 Slc39a7 Slc39a6 Slc39a5 Slc39a14 Slc39a3 Slc39a10 Slc39a4 Slc39a2 Slc39a1 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 96%6802948 Signaling by high-kinase activity BRAF mutants Arrb1 Fgb Fga Rap1b Map2k2 Ksr1 Vwf Cnksr2 Nras Cnksr1 Fgg Map2k1 Araf Mark3 Itgb3 Pebp1 Raf1 Hras Tln1 Fn1 Vcl Csk Itga2b Src Mapk1 Braf Mapk3 Ywhab Rap1a Apbb1ip Arrb2 Iqgap1 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport Arfgap1 Kdelr2 Stx5 Capzb Ykt6 Capza1 Capza2 Actr1a Mia3 Copz2 Copz1 Dctn2 Arf5 Golga2 Dctn3 Tgfa Ctsc Scfd1 Ppp6r1 Ppp6r3 Lman2 Sec22c Sec22b Sec22a Tfg Preb Trappc6b Ppp6c Trappc9 Trappc6a Trappc5 Trappc4 Sec31b Trappc3 Sec31a Trappc2 Tmem115 Trappc1 Spta1 F5 F8 Rab1a Stx17 Rab1b Sptb Trappc2l Tmed9 Gosr2 Lman1l Tbc1d20 Cd59b Tmed3 Uso1 Copg1 Sec23ip Copg2 Trappc10 Sec16b Ank3 Sec16a Mcfd2 Ank1 Lman2l Serpina1d Copb2 Cnih1 Gorasp1 Cnih3 Golgb1 Cnih2 Sptan1 Folr1 Copb1 Ankrd28 Bet1 Arf4 Sptbn1 Sptbn2 Actr10 Dctn5 Dctn6 Dctn1 Dctn4 Capza3 Sptbn4 Kdelr3 Csnk1d Gbf1 Nsf Gria1 Arf1 Arfgap2 Arcn1 Ctsz Bet1l Cog1 Kdelr1 Cog2 Cog3 Cog4 Cog6 Cog7 Cog8 Napa Napb Napg Dync1li2 Dync1li1 Areg Dynll1 Dynll2 Lman1 Copa Arfgap3 Dync1h1 Arf3 Sar1b Sec23a Cope Gosr1 Dync1i2 Dync1i1 Sec24d Sec24c Ins2 Col7a1 Sec24b Sec13 Sec24a LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN Porcn DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME%R-HSA-5632987.2 Defective Mismatch Repair Associated With PMS2 Pms2 Mlh1 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%391908 Prostanoid ligand receptors Ptger4 Ptger2 Ptgir Ptger3 Tbxa2r Ptgdr Ptgfr Ptger1 Ptgdr2 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 96%379401 Clearance of dopamine Maoa Comt Tomt Slc6a3 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 96%68867 Assembly of the pre-replicative complex H2bc9 H2bc7 Psma4 H2bc8 Psma3 H2bc3 Psma6 Psma5 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 H2ab2 Psmd13 Anapc7 Cdc27 Ube2d1 Psmb5 Cdc16 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 H2bu2 Psmb1 Anapc15 Psmb3 Psmb2 Fzr1 Psma7 Psmc6 Psmc5 Psmc2 Mcm7 Psmc1 Psmc4 Psmc3 Mcm3 Ubc Mcm4 Mcm5 Psmd7 Mcm6 Psmd6 Mcm2 Hist2h2aa1 Psmd8 Cdt1 Psmd3 Psmd2 Gmnn Psmd1 Kpna6 Adrm1 Sem1 H2bc14 H2ac20 Cdc6 H2bc21 H2bc26 Kpna1 H2ac12 H2ac11 Orc5 Orc4 Orc6 Orc1 Mcm8 H2ac15 Orc3 H3c7 Orc2 H2ax Hist1h2bp H2aj Kpnb1 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation Dusp5 Pea15 Jak2 Dusp1 Dusp10 Map2k2 Dusp9 Il6ra Dusp8 Dusp4 Map2k1 Tyk2 Dusp16 Dusp7 Dusp6 Ptpn11 Mapk1 Jak1 Mapk3 Cdk1 Il6 Dusp2 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 96%5619060 Defective CP causes aceruloplasminemia (ACERULOP) Slc40a1 Cp HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%3296197 Hydroxycarboxylic acid-binding receptors Hcar1 Hcar2 MDK AND PTN IN ALK SIGNALING%REACTOME%R-HSA-9851151.1 MDK and PTN in ALK signaling Ptn Alk Ptprz1 Mdk PPARA ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-1989781.6 PPARA activates gene expression Sp1 Srebf2 Havcr2 Angptl4 Esrra Cyp4a32 Nr1h3 Fabp1 Sult2a1 Pex11a Ncoa3 Apoa2 Apoa5 Ppargc1b Acsl1 Nr1h4 Abca1 Rxrb Slc27a1 Cyp7a1 Ugt1a9 Nr1h2 G0s2 Rora Ppara Pparg Alas1 Tnfrsf21 Trib3 Rxra Ankrd1 Cd36 Txnrd1 Fhl2 Grhl1 Plin2 Cpt2 Med9 Fads1 Agt Cdk19 Med13l Abcb4 Me1 Med8 Med4 Med23 Med6 Med24 Med25 Med20 Med26 Med27 Med12 Med13 Med14 Med10 Tiam2 Med15 Med16 Med17 Ncor2 Ahr Cyp1a1 Ahrr Nrf1 Gps2 Hmgcs2 Med22 Med21 Med28 Med29 Med11 Med19 Med30 Med18 Med31 Rgl1 Thrap3 Fam120b Ncor1 Helz2 Carm1 Cdk8 Ep300 Tbl1x Arnt Clock Fdft1 Bmal1 Hdac3 Ncoa2 Ncoa1 Tbl1xr1 Smarcd3 Acadm Mtf1 Ncoa6 Npas2 Med1 Cpt1a Nr1d1 Nfyb Glipr1 Nfya Nfyc Ppargc1a Ccnc Crebbp Apoa1 Chd9 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 96%72202 Transport of Mature Transcript to Cytoplasm Cpsf4 Nup133 Sympk Cpsf1 Cpsf2 Cpsf3 Wdr33 Fip1l1 Nup37 Nup160 Nup43 Nxt1 Rnps1 Gle1 Ranbp2 Fyttd1 Srsf1 Thoc1 Thoc2 Nup93 Thoc3 Nup50 Nup35 Thoc5 Thoc6 Nup54 Pom121 Thoc7 Nup205 Srsf9 Ddx39a Eif4e Nup188 Cdc40 Tpr Srsf7 Nup107 Rae1 Ndc1 Srsf6 Nup42 Srsf3 Magoh Nup62 Ddx39b Nup88 Srsf2 Srsf11 Aaas Srrm1 Nup214 Rbm8a Slbp Upf3b Nup210 Nup155 Zc3h11a Nup153 Slu7 Poldip3 Alyref Nxf1 Chtop Dhx38 U2af1l4 Nxf7 Eif4a3 Casc3 Magohb Nup85 Ncbp2 Ncbp1 Sec13 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism Slc19a2 Tpk1 Slc25a19 Thtpa DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 96%5545483 Defective Mismatch Repair Associated With MLH1 Pms2 Mlh1 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9840310.3 Glycosphingolipid catabolism Neu1 Asah1 Gla Gba2 Psap Sumf1 Sumf2 Arsa Gba1 Hexa Smpd1 Hexb Asah2 Gm2a Glb1 Smpd4 Glb1l3 Arsk Enpp7 Glb1l2 Arsj Galc Arsb Arsi Arsg M6pr Smpd2 Smpd3 Ctsa Neu2 Neu3 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion F9 DEFECTIVE MPI CAUSES CDG-1B%REACTOME%R-HSA-4043916.4 Defective MPI causes CDG-1b Mpi THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME DATABASE ID RELEASE 96%9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Per1 Per3 Csnk1d Clock Npas2 Bmal1 Csnk1e Crebbp Cry1 Cry2 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 96%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA Hadha Echs1 Hadhb Hadh Acadm REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975578.5 Reactions specific to the complex N-glycan synthesis pathway Fuca1 Man2a1 Lhb Chst10 Mgat2 Fut8 Chst8 Cga SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665348 Signaling by ERBB2 ECD mutants Cdc37 Erbin Nras Gab1 Plcg1 Sos1 Hras Egfr Pik3ca Erbb2 Egf Shc1 Hsp90aa1 Pik3r1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 96%5627083 RHO GTPases regulate CFTR trafficking Cftr Gopc DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 96%4793952 Defective MGAT2 causes CDG-2a Mgat2 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%70326 Glucose metabolism Prkaca Pfkm Pfkp Adpgk Pcx Aldob Aldoc Aldoa Nup133 EG433182 Gpi Prkacb Gnpda1 Gck Gnpda2 Gapdhs Slc37a4 Slc37a1 Nup37 Nup160 Gckr Ppp2cb Ppp2ca Pgk1 Nup43 G6pc1 Ranbp2 Eno3 Eno2 Nup93 Nup50 Pgk2 Nup35 Eno4 Nup54 Pom121 Nup205 Hk2 Nup188 Hk1 Tpr Hk3 Nup107 Rae1 G6pc2 Ndc1 G6pc3 Nup42 Nup62 Nup88 Aaas Pfkfb4 Nup214 Pfkfb3 Pfkfb1 Nup210 Nup155 Nup153 Ppp2r1b Ppp2r1a Pck2 Hkdc1 Pgm2l1 Nup85 Fbp1 Fbp2 Bpgm Ppp2r5d Pgam2 Pfkl Pgam1 Tpi1 Sec13 Pck1 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 96%428542 Regulation of commissural axon pathfinding by SLIT and ROBO Dcc Slit2 Src Nell2 Robo2 Ntn1 Slit1 Robo1 Slit3 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function Abca4 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702577 semaxanib-resistant FLT3 mutants Flt3 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9692916 SARS-CoV-1 activates modulates innate immune responses Pycard Fkbp1a Ppia Sting1 Pcbp2 Rcan3 Nmi Tbk1 Traf3 Irf3 Ikbke Nfkb1 Sftpd Ifih1 Sike1 Nlrp3 Trim25 Mavs Rigi Rela Itch Ripk3 Bst2 Tkfc Casp1 Irak2 Ubc Tomm70 Tlr7 Kpnb1 Ppig Ppih Nfkbia Ppib Traf6 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state Arrb1 Psma4 Cul3 Psma3 Psma6 Cdc73 Psma5 Psma2 Evc2 Psma1 Iqce Evc Gas8 Psmd12 Efcab7 Psmd11 Psmd14 Psmd13 Smurf2 Smurf1 Gli3 Psmb5 Gli2 Psmb4 Hhip Boc Psmb7 Psmb6 Gas1 Psmb1 Cdon Psmb3 Psmb2 Spop Itch Rbx1 Psma7 Psmc6 Psmc5 Ihh Psmc2 Psmc1 Psmc4 Psmc3 Shh Ubc Ulk3 Dzip1 Gpr161 Psmd7 Gli1 Spopl Psmd6 Numb Psmd8 Psmd3 Kif3a Psmd2 Psmd1 Adrm1 Sem1 Smo Csnk1a1 Dhh Ptch1 Grk2 Sufu Arrb2 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%418346 Platelet homeostasis Trpc3 Stim1 Gucy1a1 Gucy1a2 Itpr3 Itpr2 Itpr1 Pecam1 Ppp2r5e Pde5a Pde10a Pde11a Pde9a Irag1 Fgr Mapk14 Ppp2cb Pde2a Ppp2ca Kcnmb2 P2rx6 P2rx5 P2rx3 P2rx7 P2rx2 Kcnmb4 Gng10 Pafah2 P2rx4 P2rx1 Ptpn6 Prkg2 Ptpn11 Nos3 Kcnmb1 Kcnma1 Gng3 Gng2 Gng4 Gng7 Gng8 Ppp2r1b Atp2a1 Ppp2r1a Nos2 Pla2g4a Ptgir Atp2a3 Pde1b Gngt1 Atp2a2 Gngt2 Pde1a Sri Nos1 Slc8a1 Gnb2 Slc8a2 Gnb1 Slc8a3 Ppp2r5d Gucy1b1 Gnb4 Ppp2r5c Gnb3 Atp2b2 Ppp2r5b Gnb5 Trpc6 Gng11 Atp2b1 Ppp2r5a Trpc7 Atp2b4 Gng12 Atp2b3 Gng13 Orai1 Orai2 Apob CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance Apoe Ldlrap1 Ldlr Lipc Apob TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation Med26 Med27 Srebf2 Med12 Med13 Tgfb1 Med14 Med10 Havcr2 Med15 Med16 Angptl4 Med17 Ncor2 Plin1 Nfkb1 Fabp4 Rela Ncoa3 Ccnd3 Lpl Cdk4 Med22 Med21 Wnt10b Med28 Med29 Med11 Med19 Med18 Med30 Cebpb Med31 Adipoq Nr2f2 Ppara Tnf Pparg Ebf1 Egr2 Thrap3 Zfp638 Rxra Fam120b Zfp467 Cd36 Lep Ncor1 Helz2 Carm1 Ep300 Cdk8 Tbl1x Cebpd Cebpa Wnt1 Klf5 Hdac3 Ncoa2 Ncoa1 Tbl1xr1 Smarcd3 Med9 Ncoa6 Cdk19 Med1 Med13l Slc2a4 Ppargc1a Klf4 Med8 Ccnc Crebbp Med23 Med4 Med24 Med6 Med25 Chd9 Med20 Pck1 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function Bard1 Brca1 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%392851 Prostacyclin signalling through prostacyclin receptor Ptgir Gngt1 Gngt2 Gng10 Gng3 Gng2 Gnb2 Gnb1 Gng4 Gnb4 Gnb3 Gng7 Gnb5 Gng11 Gng8 Gng12 Gng13 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) Stx1b Snap25 Stx1a DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME%R-HSA-5579009.5 Defective CYP11B2 causes CMO-1 deficiency Cyp11b2 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) Kcnk4 Kcnk2 Kcnk10 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway Rpa2 Polb Apex1 Rpa3 Parp2 Parg Pole Adprs Parp1 Lig1 Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Rfc1 Rfc2 Pold4 Pold3 Pole3 Pole2 Pole4 Fen1 Rpa1 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME DATABASE ID RELEASE 96%5619097 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) Slc34a3 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9764562 Regulation of CDH1 mRNA translation by microRNAs Myc Tnrc6c Ago4 Ago3 Ago2 Ago1 Tnrc6a Tnrc6b Mycn Cdh1 Mov10 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 96%4839726 Chromatin organization Actl6a Actl6b Smarce1 Sap30l Suds3 Brms1 Rcor1 Rbm17 Sap30 Ddx46 Ddx42 Sap18b Arid4b Arid4a Pbrm1 Hmg20b Kdm1a Kdm4b Actb Chd1 Arid2 Yeats4 Ogt Sap130 Cbx3 Pwwp2a Mbd3l1 Pwwp2b Kdm5b Brwd1 Suv39h1 Suv39h2 Smyd3 Setd3 Nsd3 Setd2 Kmt5c Setd7 Setdb2 Setd6 Setdb1 Nsd1 Aebp2 Mecom Prdm9 Dot1l Atf7ip Ash1l Hdac10 Chd6 Nqo1 Myog Myod1 Cdc73 Rtf1 Ncor2 Leo1 Tcf4 Skic8 Ehmt2 Ruvbl1 Ehmt1 Mbd3 Kdm6b Ctr9 Paf1 Arid1a Arid1b Ccnd1 Kmt5a Cdk4 Ep400 Riox2 Ss18 Dpf1 Dpf2 G6pc1 Kmt2d Dpf3 Ss18l1 Kmt2b Bcl7a Bcl7b Bcl7c Jmjd6 Hdac2 Smarcb1 Hdac8 Smarca2 Smarca4 Supt20 Nsd2 Vps72 Ing4 Ing3 Smarcd1 Kat7 Supt3 Smarcd2 Msl2 Msl3 Bcl11b Msl1 Hat1 Snrpb Phf10 Prmt5 Eny2 Smarcc2 H2ac21 Padi2 Jade1 Smarcc1 Coprs Jade2 H2ac25 Brd8 Snrpd2 Hist1h2af Jade3 Snrpd1 Morf4l2 Prmt7 Morf4l1 Prmt3 Fbp1 H2ac1 Supt7l Snrpd3 Taf5l Mrgbp Wdr77 Taf6l Dmap1 Epc1 Elp2 Elp1 Elp4 Tada1 Elp3 Elp6 Elp5 Pck1 Kdm7a Prmt6 Prmt1 Phf20 Nfkb1 Hcfc1 Kat8 Yeats2 Kat14 Dr1 Adnp2 Rela Adnp Mta1 Tada3 Trrap Tada2a Mta3 Prdm16 Zzz3 H2bc18 Mbip Kansl3 Dkk2 Nr2c2 Kansl1 Kansl2 Sgf29 Kdm4c Chd8 Phf6 Zfp592 Tcf19 Padi3 Cdk2ap1 Padi4 Cdk2ap2 Padi1 Nr2f2 Padi6 Mbd2 Zmynd8 Ikzf3 Igf2 Znf687 Ikzf2 H2ac20 Ikzf1 Tcf3 Chd5 Zfp827 Hdac1 Ube2i Bicral Bicra Brd9 Meaf6 Bcl11a Pax3 Kat5 Kdm1b Kdm3a Chd3 Chd4 H2ac12 H2ac11 H2ac15 H3c7 Phf5a Ezh2 H2ax Rest Axin2 Suz12 Nfkb2 Ash2l Mta2 Hist1h2bp H2aj Puf60 Jak2 Smndc1 H2bc9 H2bc7 H2bc8 H2bc3 Gatad2a Gatad2b Ruvbl2 H2ab2 Kdm5a Kdm6a Ing5 Phf2 H2bu2 Kdm4d Kdm2b Atxn7 Kdm5d Cbx1 Kdm2a Kdm3b Kdm5c Phf8 Ctnnb1 Arid5b Gps2 Tcf12 Brd7 U2surp Kat2b Snrpb2 Kat2a Kmt2c Snrpa1 Hist2h2aa1 Smyd2 Chd2 Dpy30 Wdr5 Nkd2 Fam124b Sf3a1 Sf3a2 Eed Chd7 Sf3a3 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Sf3b5 Sf3b6 H2bc14 Setd1b Snrpn H2bc21 Setd1a H2bc26 Cherp Rbbp5 Rbbp4 Ctcf Ncor1 Rbbp7 Atf2 Brpf3 Brpf1 Carm1 Kat6a Ep300 Tbl1x Clock Hdac3 Taf12 Dnmt3a Kdm4a Ncoa2 Ncoa1 Tbl1xr1 Dhx15 Smarcd3 Taf9 Mafk Supt16 Usp22 Nfe2l2 Ssrp1 Crebbp Chd9 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) Hk1 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m Dolk EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 96%3928663 EPHA-mediated growth cone collapse Yes1 Myl6 Rock2 Rock1 Myh14 Myh10 Myh9 Rhoa Myl12a Fyn Ngef Myl12b Myh11 Lyn EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects Cdkn2a Cdk6 Cdk4 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome Apobec4 Apobec2 Apobec3 A1cf Apobec1 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Rpl24 Rpl26 Rpl22 Rpl23 Psma4 Psma3 Psma6 Rpl39l Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Rplp2 Rpl22l1 Rplp1 Ube2d1 Rpl13a Rchy1 Psmb5 Rpl18a Psmb4 Psmb7 Rpl17 Psmb6 Rpl18 Psmb1 Rpl19 Ltn1 Psmb3 Rpl10l Psmb2 Rpl11 Vcp Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Ankzf1 Psmc1 Klhdc10 Psmc4 Psmc3 Tcf25 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul2 Ufd1 Nploc4 Rpl4 Rpl37 Rpl39 Rpl7 Rpl32 Eloc REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription Nr3c1 Kcnip3 Rest Srf CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.8 Cilium Assembly Nedd1 Cc2d2a Tmem67 Actr1a Tuba1a Dynlrb2 Dynlrb1 Cep97 Cys1 Dctn2 Dctn3 Ift70b Rpgrip1l Rab11a Dynlt2a1 Cct3 Ift88 Cct2 Ift81 Ywhae Exoc3 Exoc4 Exoc5 Cluap1 Exoc6 Exoc1 Exoc2 Dynlt2b Sstr3 Exoc7 Exoc8 Ift80 Pcnt Traf3ip1 Tcp1 Arl6 Tuba4a Fbf1 Arl3 Cep250 Sdccag8 Cep78 Ift140 Dynlt5 Cep76 Iqcb1 Cep72 Cep70 Bbs2 Bbs1 Tubb5 Plk4 Ift22 Kif3a Kif3b Ift27 Kif3c Ift25 Cct8 Ahi1 Cep89 Cct5 Smo Cep135 Cct4 Nphp4 Nphp3 Cep131 Cep83 Lztfl1 Prkar2b Mks1 Nphp1 Rab11fip3 Ift52 Arf4 Mkks Unc119b Tubb4b Haus7 Tubb4a Haus8 Ttc21b Cdk5rap2 C2cd3 Ift56 Pkd2 Pkd1 Ift57 Mark4 Cep57 Pcm1 Rp2 Asap1 Ssna1 Bbs9 Mchr1 Bbs7 Tubg1 Bbs5 Ift122 Bbs4 Ofd1 Bbs10 Ift43 Bbs12 Septin2 Cep162 Ift46 Cep63 Rab3ip Cep152 Haus3 Kif24 Haus4 Haus5 Haus6 Sfi1 Ttbk2 Csnk1d Haus1 Wdr35 Haus2 Ift74 Tctn3 Tctn1 Tctn2 Cnga4 Kifap3 Hsp90aa1 Cnga2 Dync2h1 Ift70a1 Cep164 B9d1 Prkaca Ccp110 Atat1 Alms1 Gbf1 Cetn2 Tnpo1 Trip11 Rab8a Dync2li1 Dync2i1 Dync2i2 Ift172 Ttc8 Cep43 Wdr19 Cep41 Plk1 Sclt1 Ninl Cdk1 Nek2 Kif17 Cpap Clasp1 Ywhag Pafah1b1 Csnk1e Hdac6 Mapre1 Rho Inpp5e Arl13b Dynll1 Dynll2 Pde6d Ppp2r1a Dync1h1 Dync1i2 Ckap5 Akap9 B9d2 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 96%9937383 Mitochondrial ribosome-associated quality control Mrpl14 Mrps30 Mrpl16 Mrps31 Mrpl17 Mrps33 Mrpl18 Mrpl19 Aurkaip1 Mrps34 Mrps35 Gadd45gip1 Mrpl20 Mrpl3 Mrpl43 Mrpl4 Mrpl44 Mrpl1 Mrpl46 Mrpl2 Mrpl47 Mrpl48 Ndufab1 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrpl9 Mrps25 Mrps26 Mrps27 Mrps28 Mrps18c Mrps18b Mrps18a Mrpl50 Mrpl51 Mrpl52 Mrpl53 Mrpl32 Mrpl33 Oxa1l Mrpl34 Mrpl35 Mrps9 Mrpl36 Mrpl37 Mrpl38 Mrpl39 Mrps10 Mrps11 Mrps12 Mrps14 Chchd1 Mrps15 Mrps16 Mrps17 Ptcd3 Mrps2 Mrps6 Mrps7 Mrpl40 Mrpl41 Mrps5 Mrpl21 Mrpl22 Mrpl24 Mrpl28 Eral1 Mrpl30 Mief1 Mtres1 Mrpl10 Mrpl54 Dap3 Mrpl11 Mrpl55 Mrpl12 Mrpl13 Mrpl57 Mrpl58 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling Ngf Ntrk1 Plcg1 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 96%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P Taldo1 SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions Myl6 Plxnd1 Pak1 Plxnc1 Sema6d Pak3 Arhgap35 Sema6a Pak2 Sema4a Rhoc Plxnb1 Tln1 Sema3a Sema3e Cdk5r1 Cdk5 Sema5a Fes Hsp90ab1 Rock2 Rock1 Myh14 Myh10 Pip5k1c Sema4d Rnd1 Rras Limk1 Limk2 Met Plxna1 Plxna4 Farp2 Gsk3b Nrp1 Dpysl2 Rhoa Fyn Itga1 Crmp1 Tyrobp Ptprc Rhob Trem2 Myh9 Sema7a Arhgef11 Myl12a Erbb2 Myl12b Rac1 Itgb1 Dpysl3 Myh11 Dpysl4 Dpysl5 Cd72 Plxnb3 Hsp90aa1 Plxna3 Cfl1 Plxna2 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 Cyp4f39 CHYLOMICRON REMODELING%REACTOME%R-HSA-8963901.2 Chylomicron remodeling Apoc2 Apoe Apoa2 Apoa4 Apoa5 Apoc3 Apoa1 Lpl Gpihbp1 Apob NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%112310 Neurotransmitter release cycle Naaa Chat Rab3a Dnajc5 Cplx1 Arl6ip5 Gad1 Gad2 Cask Maoa Lin7a Lin7b Lin7c Snap25 Syt1 Vamp2 Stx1a Slc1a1 Slc5a7 Slc1a3 Aldh5a1 Slc1a2 Slc18a2 Slc18a3 Slc38a2 Slc6a11 Slc6a13 Abat Unc13b Slc22a2 Slc1a7 Hspa8 Slc22a1 Slc1a6 Gls2 Gls Slc6a1 Apba1 Syn3 Syn2 Syn1 Ppfia2 Ppfia4 Ppfia1 Slc6a12 Slc32a1 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation Wasl Cygb Cyb5b Lypla1 Ddah1 Dnm2 Spr Nmt1 Nosip Nos3 Cav1 Akt1 Hsp90aa1 Zdhhc21 Nostrin Nmt2 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen Minpp1 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Plcb3 Gnaq Plcb2 Plcb1 Gna11 Ffar1 Gna15 Gna14 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Psma4 Psma3 Psma6 Psma5 Psma2 Anapc5 Psma1 Anapc4 Anapc1 Anapc2 Psmd12 Anapc11 Psmd11 Ube2c Psmd14 Anapc10 Psmd13 Anapc7 Cdk1 Cdc27 Ube2d1 Psmb5 Cdc16 Nek2 Psmb4 Anapc16 Psmb7 Ube2e1 Cdc23 Psmb6 Psmb1 Anapc15 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Ccna1 Psmd7 Ccna2 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cdc20 Mad2l1 Bub1b Bub3 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants Kit MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME%R-HSA-9916720.1 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 Echs1 M PHASE%REACTOME%R-HSA-68886.5 M Phase Tuba1b Tuba1a Fbxo5 Ankle2 Tuba1c Golga2 Tubal3 Chmp2a Ywhae Tubb2b Chmp3 Tubb2a Chmp7 Chmp6 Lmnb1 Lpin3 Lpin2 Lpin1 Tuba4a Chmp4c Chmp4b Ppp2r2a Tuba8 Tuba3b Tubb6 Tubb3 Prkar2b Tubb1 Tubb4b Tubb4a Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Banf1 Nup210 Nup155 Nup153 Nek9 Nek6 Nek7 Kpnb1 Hsp90aa1 Prkaca H3c8 Ran Rb1 Kmt5a Cpap Clasp1 Clasp2 Pafah1b1 Smc3 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Rad21 Kif2b Kif2c Dync1li2 Pmf1 Wapl Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Stag2 Stag1 Ppp2r1b Ppp2r1a Pds5b Pds5a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Nuf2 Ccnb2 Nup85 Cdca8 Incenp Cdca5 Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Akap9 Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Nedd1 Cenpt Cenps Cenpq Actr1a Cenpp Ppp2r5e Psma4 Cenpo Cenpn Spast Psma3 Cenpm Dctn2 Espl1 Psma6 Mis12 Dctn3 Psma5 Lemd2 Nup133 Psma2 Cenpl Cc2d1b Psma1 Ist1 Zwilch Cenpk Vrk1 Cenpi Sirt2 Cenph Psmd12 Psmd11 Smc1a Cenpf Psmd14 Cenpe Psmd13 Psmb5 Nipbl Psmb4 Psmb7 Ensa Psmb6 Rab2a Psmb1 Ctdnep1 Cnep1r1 Psmb3 Blzf1 Psmb2 Ppp2r2d Pcnt Ncaph2 Arpp19 Prkcb Ncapd3 Ncapg2 Psma7 Mau2 Cep250 Sdccag8 Psmc6 Gorasp2 Cep78 Psmc5 Rab1a Mastl Psmc2 Mcph1 Psmc1 Rab1b Cep76 Psmc4 Psmc3 Cep72 Ubc Cep70 Psmd7 Uso1 Psmd6 Tubb5 Plk4 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Gorasp1 Sem1 Cep135 Cep131 Prkca Haus7 Haus8 H2ac20 Cdk5rap2 Ube2i Eml4 Cep57 Pcm1 Ssna1 Tubg1 Ofd1 Pttg1 H2ac12 H2ac11 Kif23 Kif20a H2ac15 Cep63 H3c7 Cep152 H2ax Haus3 Csnk2a2 Haus4 Rcc1 Haus5 Haus6 Sfi1 Csnk1d Haus1 Hist1h2bp Vps4a Haus2 H2aj Firrm Cep164 Ccp110 Alms1 Smc4 Smc2 Cetn2 Tubgcp2 Tnpo1 Numa1 Ncaph Tubg2 Ncapd2 Nme7 H2bc9 H2bc7 Tubgcp5 H2bc8 Tubgcp4 Cep43 Tubgcp3 H2bc3 Mzt1 Mzt2 Cep41 Plk1 Ninl Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 H2ab2 Anapc7 Cdk1 Cdc27 Ube2d1 Cdc16 Anapc16 Nek2 Ube2e1 Cdc23 Anapc15 H2bu2 Mapk1 Hist2h2aa1 Ywhag Csnk2b Csnk1e H2bc14 H2bc21 H2bc26 Emd Lemd3 Lbr Xpo1 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975957.3 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Rps5 Rpl24 Dcp1a Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Rpl39l Rps15a Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Rps4x Ppp2r2a Upf1 Upf3a Eif4g1 Gspt2 Gspt1 Ppp2ca Rnps1 Smg1 Pabpc1 Smg9 Smg8 Smg7 Smg6 Smg5 Upf2 Magoh Etf1 Rps27 Rbm8a Upf3b Ppp2r1a Eif4a3 Casc3 Magohb Rps14 Rpl4 Rps16 Ncbp2 Rps18 Ncbp1 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly Gja3 Gja5 Gja4 Gja8 Gja1 Gjc2 Gjb2 Gjb4 Gjb3 Gjb6 Gjb5 Gjd4 Gjd2 Gjd3 Gjc1 Gjb1 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%426496 Post-transcriptional silencing by small RNAs Tnrc6c Ago4 Ago3 Ago2 Ago1 Tnrc6a Tnrc6b NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus Neurl1a Dll1 Notch2 Mib1 Mdk Mib2 Ubc Psen1 Psen2 Ncstn Aph1b Cntn1 Dll4 Jag2 Jag1 Adam10 Neurl1b BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 96%196299 Beta-catenin phosphorylation cascade Ppp2cb Ppp2ca Gsk3b Ctnnb1 Csnk1a1 Frat2 Ppp2r5e Frat1 Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 96%166020 Transfer of LPS from LBP carrier to CD14 Lbp Cd14 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Cenpo Cenpn Cenpm Mis12 Nup133 Cenpl Zwilch Cenpk Cenpi Cenph Cenpf Cenpe Plk1 Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Clasp1 Clasp2 Pafah1b1 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Kif2b Kif2c Dync1li2 Pmf1 Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Ppp2r1b Ppp2r1a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Xpo1 Nuf2 Nup85 Cdca8 Incenp Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE Abhd4 Mboat1 Pla2g2e Pla2g2d Pla2g4a Pla2g2f Pla2g4d Lpcat4 Plaat1 Pla2g12a Plaat5 Pla2g5 Pla2g1b Pla2r1 Pla2g4f Pla2g4c Pla2g4e Lpcat3 Pla2g10 Plbd1 Pnpla8 Plaat3 Pla2g3 Pla2g6 Mboat2 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME%R-HSA-9656249.3 Defective Base Excision Repair Associated with OGG1 Ogg1 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 96%196843 Vitamin B2 (riboflavin) metabolism Slc52a2 Enpp1 Slc52a3 Rfk Acp5 Flad1 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 96%9754706 Atorvastatin ADME Slco1b2 Pon3 Abcc2 Cyp3a16 Pon1 Ugt1a2 Abcb1a DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 96%9938206 Developmental Lineage of Mammary Stem Cells Fgf10 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 96%8951936 RUNX3 regulates p14-ARF Kras Runx3 Brd2 Tgfb1 Cbfb Ccnd1 Ep300 Hdac4 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance Apoe Nr1h2 Nceh1 Clta Apobr Ap2m1 Cltc Ldlrap1 Amn Soat2 Nr1h3 Soat1 Lsr Mylip Ap2a2 Npc2 Ap2a1 Npc1 Ldlr Hdlbp Ap2b1 Ubc Ces3b Ap2s1 Apoc1 Lipa Lipc Pcsk9 Vldlr Apoc4 Apoa1 Apob Cubn MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%9637628 Modulation by Mtb of host immune system B2m Tlr2 Mrc1 Ubc WAX BIOSYNTHESIS%REACTOME%R-HSA-9640463.3 Wax biosynthesis Far2 Far1 Awat1 Awat2 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System Tlr4 Fgb Fga Fgg Ikbkb S100a1 S100a9 Cd36 S100a8 Myd88 Tirap Traf3 Ikbkg Ticam1 F12 Klkb1 Tlr1 Cd14 Btk Tlr6 Tlr2 Nfkb1 F2 Tlr5 Rela Serping1 Irak4 Nfkb2 Unc93b1 Tlr7 Tlr3 Ly96 Nfkbia Chuk SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins Wdr48 Strn Fip1l1 REGULATION OF TNFR1 SIGNALING%REACTOME%R-HSA-5357905.8 Regulation of TNFR1 signaling Usp2 Sharpin Usp21 Traf1 Tnf Spata2 Rnf31 Tnfrsf1a Usp4 Rbck1 Cyld Ikbkb Otud7b Tnfaip3 Birc3 Mib2 Birc2 Tbk1 Ikbkg Tradd Traf2 Ikbke Xiap Optn Ube2d1 Fadd Ube2l3 Casp8 Tax1bp1 Ulk1 Clip3 Ripk1 Stub1 Ube2d3 Ubc Sppl2b Otulin Sppl2a Rack1 Mapkapk2 Chuk GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%6783984 Glycine degradation Amt Gldc Ogdh Dlst Gcsh Dld AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 Trp53 Psma4 Atm Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Cop1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) Slco2a1 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 96%8953854 Metabolism of RNA Dnajc8 Rbm22 Rbm17 Ddx46 Ddx42 Sap18b Igf2bp3 Igf2bp2 Ddx23 Elac2 Sympk Cstf1 Papola Clp1 Nudt21 Cpsf1 Cstf2 Cpsf2 Cstf3 Cpsf3 Cstf2t Wdr33 Nop58 Skic3 Dcps Hbs1l Nt5c3b Hspb1 Zfp36 Skic8 Nup37 Nup160 Ppp2ca Nup43 Ranbp2 Fastkd5 Tbrg4 Smg1 Smg9 Smg8 Smg7 Smg6 Smg5 Nup107 Rps27 Ppp2r1a Gemin7 Gemin4 Gemin5 Hsd17b10 Prorp Snrpb Prmt5 Trub2 Nsun4 Smn1 Snupn Trmt10c Rpusd4 Snrpd2 Tfb1m Snrpd1 Nup85 Mterf4 Clns1a Phax Mterf3 Rcc1l Snrpd3 Gemin2 Mrm1 Mrm2 Ddx20 Wdr77 Mrm3 Ngrn Fastkd2 Tent4a Sec13 Adar Ppil2 Nup133 Hnrnpu Znf830 Zfp36l1 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Rnmt Ercc3 Cdk7 Rngtt Prkca Mettl3 Rexo2 Tut7 Trmu Tut4 Yrdc Mto1 Osgepl1 Paip1 Mettl14 Gtpbp3 Pan2 Supv3l1 Pan3 Pnpt1 Akt1 Apobec4 Apobec2 Apobec3 A1cf Apobec1 Exosc9 Csnk1d Exosc8 Exosc5 Dis3 Exosc4 Exosc7 Exosc6 Parn Exosc1 Exosc3 Exosc2 Tnpo1 Trp53rkb Csnk1e Cnot11 Osgep Trmt5 Cnot10 Wdr4 Urm1 Ctu1 Ctu2 Trmt44 Mettl1 Tyw1 Trmt1 Thada Cdkal1 Ftsj1 Trit1 Trmt9b Pus3 Qtrt2 Tnks1bp1 Qtrt1 Trmt61a Trdmt1 Tyw2 Lcmt2 Tyw3 Tyw5 Pus7 Dus2 Trmt10a Trmt11 Nsun2 Ncbp2 Trmt13 Ncbp1 Tprkb Nsun6 Adat1 Alkbh8 Adat2 Thg1l Dcp2 Lsm2 Lsm3 Lsm4 Lsm5 Dcp1a Cnot6l Dcp1b Lsm1 Edc3 Edc4 Xrn1 Lsm6 Lsm7 Patl1 Ddx6 Skic2 Ppp1ca Ppp1cb Ddx5 Xrn2 Nop2 Ppp2r2a Slirp Upf3a Mtpap Lrpprc Gspt2 Gspt1 Ybx1 Nop56 Pabpc1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Upf2 Rae1 Ndc1 Nup42 Nup62 Nup88 Etf1 Aaas Nup214 Slbp Nup210 Lsm10 Nup155 Lsm11 Nup153 Rps14 Rpl4 Las1l Rps16 Rrp1 Rps18 Rps19 Ltv1 Mtrex Rrp9 Rpsa Rpl37 Rpp38 Rpl39 Pwp2 Bysl Rps10 Fbl Rps11 Rpp30 Rpl7 Ftsj3 Imp3 Rpp21 Rpl32 Imp4 Rps9 Rpp25 Rps7 Dkc1 Rps5 Nhp2 Rpl24 Wdr75 Rpl26 Senp3 Rpl22 Isg20l2 Rpl23 Dimt1 Exosc10 Grsf1 Emg1 Eri1 Dhx37 Rps25 Gar1 Rps26 Pno1 Pdcd11 Rps21 Utp20 Nop14 Pelp1 Cpsf4 Rpl39l Papolg Utp25 Rcl1 Rbm26 Nop10 Rps15a Rbm27 Tbl3 Ythdc2 Zcchc8 Nol12 Ythdc1 Nol11 Zc3h18 Prpf40a Rpp40 Zfc3h1 Snrnp70 Wdr3 Htatsf1 Rps27l Bud23 Rbm7 Tent4b Rplp2 Ppp1r8 Dcaf13 Rpl22l1 Snrpa Dxo Utp15 Rplp1 Snrpc Rbm28 Riok3 Rbm25 Rpl13a Heatr1 Rpl18a Srsf10 Tut1 Hspa1a Utp11 Rpl17 Nob1 Ppp1r10 Rpl18 Tcerg1 Nat10 Rpl19 Ddx52 Rbm39 Utp18 Rpl10l Wdr43 Rpl11 Wdr46 Noc4l Rps3 Riok1 Rps4x Riok2 Pabpn1 Gnl3 Ran Ddx49 Ddx47 Thumpd1 Nip7 Tsr3 Rrp36 Nol9 Hspa8 Mphosph6 Rpp14 Nol6 Utp14a Mphosph10 Pes1 Trmt112 Bms1 C1d Krr1 Utp3 Cnot3 Utp4 Cnot2 Utp6 Cnot1 Cnot7 Bop1 Igf2bp1 Cnot6 Ebna1bp2 Wdr18 Tsr1 Cnot4 Ddx21 Wdr12 Cnot9 Cnot8 Nxt1 Rnps1 Gle1 Fyttd1 Srsf1 Thoc1 Thoc2 Thoc3 Thoc5 Thoc6 Thoc7 Srsf9 Ddx39a Eif4a2 Cdc40 Eif4a1 Srsf7 Srsf6 Srsf3 Magoh Ddx39b Srsf2 Srsf11 Srrm1 Rbm8a Upf3b Zc3h11a Slu7 Poldip3 Acin1 Alyref Nxf1 Chtop Dhx38 U2af1l4 Tnfsf13 Anp32a Nxf7 Prkcd Eif4a3 Elavl1 Casc3 Magohb Ddx41 Psma4 Dhx9 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Trnt1 Psmb5 Psmb4 Psmb7 Psmb6 Wdr82 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Prpf4 Leng1 Prpf3 Fam50a Prpf31 Zmat2 Cactin Pnn Zfp473 Rnf113a2 Sf1 Rbmx2 Nsrp1 Tfip11 Prpf18 Ik Dhx8 Wdr70 Snip1 Fam32a Steep1 Dhx35 Ywhaz Yju2 Smu1 Lsm8 Gpatch1 Ppwd1 Snrnp27 Gcfc2 Ccdc12 Ubl5 Syf2 Phf5a Prpf4b Sde2 Eprs1 Usp39 Crnkl1 Sart1 Wbp4 Cwf19l2 Mfap1b Prpf38a Prkrip1 Nkap Rbm42 Luc7l3 Bud13 Xab2 Hnrnpa2b1 Zcrb1 Prpf19 Puf60 Bcas2 Gpkow Smndc1 Aqr Pcbp2 Pcbp1 Hnrnpr Snrnp25 Zmat5 Snrnp48 Sugp1 Snrnp35 Hnrnpd Zrsr2 Hnrnpf Rnpc3 Hnrnpk Pdcd7 Ccar1 Hnrnpl Hnrnpm Rbmx Hnrnph2 Adarb1 Hnrnph1 Tra2b Cwc22 Cwc27 Cpsf7 Hnrnpc Cwc25 Cwc15 Rbm5 Txnl4a Fip1l1 Snrnp200 U2surp Snrpb2 Snrpa1 Ptbp1 Ywhab Upf1 Mapkapk2 Mapk14 Eif4g1 Sf3a1 Sf3a2 Sf3a3 Pop7 Pop5 Pop4 Sf3b1 Pop1 Sf3b2 Fam98b Sf3b3 Sf3b4 Zbtb8os Sf3b5 Tsen34 Sf3b6 AI597479 Rtraf Ctnnbl1 Xpot Rtcb Srrt Tsen15 Snrnp40 Mapk11 Ddx1 Eftud2 Tsen54 Tsen2 Eif4b Eif4e Snrpn Cherp Fus Isy1 Cdc5l Plrg1 Hnrnpa3 Ppil4 Ppil3 Hnrnpa1 Ppil1 Prcc Rbm10 Xpo1 Dhx16 Dhx15 Srrm2 Prpf6 Ppig Ppih Ppie Prpf8 Wbp11 Pqbp1 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Avpr1b Avpr1a Avp TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5668541 TNFR2 non-canonical NF-kB pathway Psma4 Psma3 Psma6 Birc3 Psma5 Birc2 Edar Psma2 Psma1 Traf3 Cd40lg Traf2 Psmd12 Tnfsf4 Psmd11 Tnfsf8 Map3k14 Psmd14 Psmd13 Cd27 Fasl Cd70 Skp1 Tnfsf15 Tnfsf14 Psmb5 Tnfsf12 Ube2m Psmb4 Tnfsf18 Tnfrsf11b Psmb7 Tnfrsf11a Psmb6 Psmb1 Tnfrsf17 Tnfrsf18 Psmb3 Tnfrsf25 Psmb2 Fbxw11 Tnfrsf13c Btrc Tnfrsf13b Psma7 Tnfrsf12a Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Edaradd Psmc3 Lta Ubc Ltb Ltbr Psmd7 Psmd6 Tnfrsf4 Tnfrsf8 Tnfsf13b Psmd8 Psmd3 Psmd2 Psmd1 Tnfrsf9 Adrm1 Eda2r Sem1 Cul1 Eda Chuk Tnf Tnfrsf1b Tnfrsf1a Relb Uba3 Tnfsf11 Tnfsf13 Nfkb2 Tnfrsf14 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 96%5690338 Defective ABCC6 causes PXE Abcc6 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%4419969 Depolymerization of the Nuclear Lamina Ctdnep1 Lemd2 Cnep1r1 Lpin3 Lpin2 Lpin1 Emd Prkcb Lemd3 Cdk1 Prkca Lmnb1 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6787450 tRNA modification in the mitochondrion Gtpbp3 Trit1 Hsd17b10 Prorp Trmt10c Trmu Yrdc Mto1 Osgepl1 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 96%3359471 Defective MMAB causes MMA, cblB type Mmab SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants Pik3ca Stat3 Stat1 Nras Pdgfra Pik3r1 Pik3cb Sos1 Pik3r2 Hras BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins Alox5 Lta4h Alox15 ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling Kdm7a Arrb1 Ppp1cc Jak2 Zc3hav1 Fgb Clcn6 Fga Spred1 Agk Rap1b Spred3 Aggf1 Ksr1 Spred2 Qki Vwf Fam131b Cnksr2 Cnksr1 Fgg Araf Nf1 Itgb3 Pebp1 Raf1 Tln1 Map3k11 Vcl Fn1 Bcl2l11 Ppp1cb Src Papss1 Dusp16 Mapk1 Braf Mapk3 Ywhab Rap1a Shoc2 Mras Dusp10 Dusp9 Map2k2 Dusp8 Nras Map2k1 Mark3 Hras Csk Itga2b Dusp7 Camk2g Dusp6 Camk2d Camk2b Kras Camk2a Mprip Ap3b1 Kiaa1549 Tent4a Akap9 Snd1 Atg7 Lmna Brap Trak1 Phb1 Agtrap Trim24 Apbb1ip Fam114a2 Arrb2 Iqgap1 Fxr1 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME%R-HSA-5632928.2 Defective Mismatch Repair Associated With MSH2 Msh6 Msh2 Msh3 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 96%2024096 HS-GAG degradation Sgsh Hpse Sdc1 Naglu Idua Gpc1 Gpc3 Gpc2 Agrn Hspg2 Gpc5 Sdc4 Sdc3 Gpc4 Sdc2 Hpse2 Gpc6 Ids DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME DATABASE ID RELEASE 96%5619072 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) Slc35a2 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.3 Defective cofactor function of FVIIIa variant F8 F9 F10 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling Prkar2a Prkaca Prkar2b Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Adcy9 Prkar1a Prkacb Prkar1b INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 96%8984722 Interleukin-35 Signalling Jak2 Il12rb2 Canx Stat3 Jak1 Stat1 Il27ra Il12a Stat4 Il6st Tyk2 Ebi3 PROTEIN LIPOYLATION%REACTOME%R-HSA-9857492.1 Protein lipoylation Lias Lipt1 Nfu1 Lipt2 Dbt Dlst Gcsh Ndufab1 Fdx1 Dlat TGFBR1 KD MUTANTS IN CANCER%REACTOME%R-HSA-3656532.4 TGFBR1 KD Mutants in Cancer Smad2 Smad3 Tgfb1 Tgfbr1 Tgfbr2 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism Adal Nt5c2 Pck1 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling Saa3 Mapk1 Capza1 Mapk3 Prkcsh Capza2 S100b App Lgals3 Ager Ddost CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960525 CASP5-mediated substrate cleavage Gsdmd Il1b Casp3 Il18 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-HSA-75876.10 Synthesis of very long-chain fatty acyl-CoAs Tecrl Tecr Acsbg1 Elovl6 Acsbg2 Acsl5 Elovl3 Elovl5 Acsl6 Acsl3 Slc27a3 Acsl4 Acsf3 Acsl1 Hsd17b3 Elovl4 Hacd1 Hsd17b12 Elovl1 Hacd2 Hacd3 Elovl7 Hacd4 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9818025 NFE2L2 regulating TCA cycle genes Idh1 Me1 Nfe2l2 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair Actl6a Xrcc1 Lig3 Rnf111 Actb Uvssa Znf830 Rbx1 Ubc Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Ube2n Ube2v2 Gtf2h4 Gtf2h3 Gtf2h5 Ercc2 Ccnh Sumo3 Ercc3 Cdk7 Pias3 Ercc8 Ube2i Pias1 Ddb1 Lig1 Cul4a Cul4b Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Rfc1 Rfc2 Pold4 Pold3 Ercc6 Pole3 Pole2 Pole4 Xab2 Prpf19 Ddb2 Rpa1 Rpa2 Cetn2 Aqr Rpa3 Polk Nfrkb Usp45 Parp2 Pole Ino80e Tfpt Ino80d Ino80c Parp1 Ino80b Actr5 Actr8 Ruvbl1 Xpa Xpc Rad23a Rad23b Cops4 Cops3 Cops6 Cops2 Yy1 Ercc1 Ercc4 Ercc5 Cops8 Chd1l Ino80 Cops7a Cops7b Cops5 Usp7 Isy1 Ell Tcea1 Ppie REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription Fosb Brd4 H2bc9 H2bc7 H2bc8 Jun H2bc3 Tead3 Tead2 Tead1 Stat3 Stat1 H2ab2 Nfkb1 Mycn H2bu2 Rela Ctnnb1 Tcf7 Wwtr1 Kmt2c Hist2h2aa1 Epas1 Dpy30 Wdr5 Eed Irf1 Lef1 H2bc14 H2ac20 Myc H2bc21 H2bc26 Rbbp5 Rbbp4 Atf3 Rbbp7 Jund Hif1a Tcf7l1 Ep300 Tcf7l2 H2ac12 H2ac11 H2ac15 H3c7 Ezh2 H2ax Tead4 Suz12 Nfkb2 Ash2l Hist1h2bp Fos H2aj Nfe2l2 Crebbp Yap1 SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655253 Signaling by FGFR2 in disease Fgf16 Frs2 Fgf18 Fgf2 Fgf1 Nras Fgf4 Gab1 Fgf10 Plcg1 Fgf3 Fgf6 Sos1 Fgf7 Fgf9 Hras Fgf20 Fgf23 Fgf22 Fgfr2 Polr2c Polr2d Ncbp2 Pik3ca Polr2a Ncbp1 Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Pik3r1 Gtf2f2 Gtf2f1 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 96%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) Slc6a2 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation Gp9 Gp1bb F9 Gp5 Gp1ba GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling Prkaca Gnat3 Prkar2b Gng10 Itga5 Gng3 Gng2 Gper1 Prkar1a Gng4 Gng7 Gng8 Prkacb Prkar2a Src Gngt1 Gngt2 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Gnaz Adcy9 Itgb1 Gnb2 Gnb1 Gnb4 Gnai2 Gnb3 Gnai1 Gnb5 Gng11 Gnai3 Gng12 Prkar1b Gng13 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) Pyurf Pigc Pigb Piga Pigm Pigl Pigg Pigf Pigh Dpm2 Pigo Pign Pigz Pigw Pigx SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654704 SHC-mediated cascade:FGFR3 Fgf16 Fgf23 Fgf18 Fgf2 Nras Fgf1 Fgf4 Sos1 Fgf9 Hras Fgf20 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions Itgb5 Tgfb1 Itgb3 Sntg2 Dtna Cask Lama5 Dtnb Sgcz Vtn Snta1 Lamb2 Lama1 Sspn Dmd Lamc3 Lamb3 Sntb2 Lama2 Sntb1 Lama3 Sgce Lama4 Sgcd Sgcb Lamc1 Lamb1 Sgca Lamc2 Sgcg Trappc4 Actn1 Ttr Itgav Agrn Nrxn1 Ddr2 Dag1 Tnc Fgf2 Ddr1 Prkca Pdgfa Hspg2 Sdc4 Itga6 Sdc3 Sdc2 Itgb4 Pdgfb Itga2 Utrn Ntn4 Sdc1 Itgb1 Drp2 Thbs1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Trp73 Trp53 Trp53bp2 Atm Ppp1r13b Steap3 Aifm2 Bax Trp53inp1 Trp63 Bnip3l Crebbp Triap1 Bid Prelid1 Prelid3a KW2449-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702569 KW2449-resistant FLT3 mutants Flt3 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 96%69231 Cyclin D associated events in G1 Ppp2cb Jak2 Ppp2ca Ccnh Cdk7 Rbl2 Cdkn2a Cdkn2b Cdkn2c Rbl1 Abl1 Skp1 Lyn Ppp2r1b Ppp2r1a Ccne1 Ccne2 Tfdp2 Tfdp1 Skp2 Rb1 Ccnd2 Ccnd3 E2f4 Ccnd1 E2f5 Cdk6 Cdk4 Ubc Cdk2 Ptk6 E2f1 Cks1b E2f2 E2f3 Ppp2r2a Cdkn1a Cdkn1b Cdkn1c Mnat1 Cul1 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA Phlda1 Aurka REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome Vhl Rb1 Zcrb1 Ddx5 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism Sgpl1 Acer1 Acer2 Acer3 Plpp2 Aldh3b1 Plpp3 Sgpp2 Sgpp1 Plpp1 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) Slc4a4 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm Foxa1 Smad2 Foxh1 Ctnnb1 Tcf7 Smad3 Lef1 Foxa2 Tead4 Shh Tead2 Noto Yap1 T ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria Bad Ppp3r1 Ywhah Bcl2 Akt3 Akt2 Akt1 Sfn Ppp3cc Ywhae Ywhab Ywhag Bid Ywhaz PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963898 Plasma lipoprotein assembly Prkaca Apoe Apoa2 Sar1b Apoa4 Apoc1 Apoc2 Abca1 Zdhhc8 Mttp Apoc3 Apoc4 Prkacb Apoa1 P4hb A2m Apob SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 Fcer2a Mdk Mib2 Cntn1 Dll4 Hes1 Jag2 Jag1 Ep300 Adam10 Neurl1b Neurl1a Gzmb Dll1 Notch2 Mib1 Mamld1 Ubc Psen1 Psen2 Ncstn Maml1 Aph1b Maml2 Hes5 Rbpj SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME%R-HSA-174495.3 Synthesis And Processing Of GAG, GAGPOL Polyproteins Vps28 Ubap1 Tsg101 Mvb12a Mvb12b Vps37a Vps37b Vps37c Nmt2 Vps37d Ubc REPLICATION OF THE SARS-COV-1 GENOME%REACTOME DATABASE ID RELEASE 96%9682706 Replication of the SARS-CoV-1 genome Vhl Rb1 Zcrb1 Ddx5 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 96%5609974 Defective PGM1 causes CDG1t Pgm1 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8934593 Regulation of RUNX1 Expression and Activity Src Ago4 Ago3 Ago2 Ago1 Ccnd2 Ccnd3 Cbfb Ccnd1 Cdk6 Ptpn11 Tnrc6c Tnrc6a Tnrc6b Pml Mov10 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME%R-HSA-5654227.4 Phospholipase C-mediated cascade; FGFR3 Fgf16 Fgf23 Fgf18 Fgf2 Fgf1 Fgf4 Plcg1 Fgf9 Fgf20 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9969896 Lanosterol biosynthesis Acat2 Fdps Fdft1 Idi1 Mvk Ggps1 Plpp6 Lss Pmvk Sqle Mvd DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME DATABASE ID RELEASE 96%9930449 Defective cleavage of FV variant at a.a.534 Pros1 F5 Proc TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids Slc27a6 Lcn12 Slc27a1 Apod Slc27a4 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 96%4687000 Defective MPDU1 causes CDG-1f Mpdu1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 96%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB Maoa Maob DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME%R-HSA-4720489.4 Defective ALG12 causes CDG-1g TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 96%75944 Transcription from mitochondrial promoters Tfb2m Tfam Mterf1b Polrmt CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress Eif2s3x Eif2s2 Eif2s1 Phb2 Dele1 Stoml2 Oma1 Eif2ak1 Yme1l1 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway Tlr4 Ppp1cc Havcr2 Tyk2 Ifnar1 Cd14 Ppp1ca Ppp1cb Stat2 Rbx1 Ubc Becn1 Cul5 Hspg2 Sdc4 Sdc3 Sdc2 Sdc1 Csnk2a2 Med9 Cdk19 Eif2ak2 Med13l Jak1 Map1b Kpnb1 Med8 Hsp90aa1 Med4 Med23 Med6 Med24 Med25 Med20 Med26 Cd209d Med27 Med12 Med13 Med14 Med10 Med15 Med16 Isg15 Med17 Gpc1 Gpc3 Gpc2 Tlr6 Gpc5 Tlr2 Arih1 Gpc4 Gpc6 Sec11c Hsp90ab1 Sec11a Ifih1 Trim25 Mavs Rigi Cx3cr1 Rab5a Rab5c Oas2 Rab5b Igf1r Hspa8 Egfr Agrn Furin Med22 Ifnb1 Med21 Med28 Med29 Med11 Med19 Med30 Med18 Med31 Csnk2b Bcap31 H2bc14 Cd209a Irf3 Cdk8 Ep300 Xpo1 Spcs3 Spcs1 Ube2l6 Spcs2 Med1 Tlr7 Tlr3 Ccnc Ly96 Crebbp Eloc ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 96%1247673 Erythrocytes take up oxygen and release carbon dioxide Ca2 Hbbt1 Ca4 Rhag Slc4a1 Aqp1 Ca1 Hba-a1 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 96%112126 ALKBH3 mediated reversal of alkylation damage Alkbh3 Ascc1 Ascc3 Ascc2 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 96%9759774 Diseases of mitochondrial beta oxidation Mmaa Mmut NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression Sap30l Suds3 Sap30 H2bc9 Sap18b H2bc7 H2bc8 Rrp8 Arid4b H2bc3 H2ab2 Polr1c Polr1d H2bu2 Ttf1 Polr1b Polr1a Polr1g Polr1e Polr1h Sap30bp Taf1d Polr2h Hist2h2aa1 Taf1a Polr2e Taf1c Polr2f Taf1b Polr2k Mnat1 Sap130 Baz2a Ubtf Gtf2h2 Gtf2h1 Gtf2h4 Gtf2h3 Gtf2h5 Ercc2 Ccnh Ercc3 Mbd2 Cdk7 H2bc14 H2ac20 Hdac2 Hdac1 H2bc21 H2bc26 Suv39h1 H2ac12 H2ac11 Sin3a Sin3b H2ac15 Tbp Smarca5 Dnmt3b H3c7 Dnmt1 H2ax Hist1h2bp H2aj Sirt1 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 96%425397 Transport of vitamins, nucleosides, and related molecules Slc35d1 Slc35a2 Slc28a1 Slc35c1 Slc29a3 Slc29a2 Slc28a3 Slc28a2 Slc29a4 Slc29a1 Slc27a6 Slc35b4 Slc35d2 Slc35b3 Slc35b2 Slc35a3 Apod Slc25a5 Slc25a4 Slc35a1 Arl2 Slc5a6 Pdzd11 Lcn12 Slc33a1 Slc27a1 Arl2bp Slc27a4 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 96%9939291 Matriglycan biosynthesis on DAG1 Slc35a4 Large1 Chst10 B4gat1 Fkrp Large2 Fktn Crppa Rxylt1 Dag1 Slc35a1 Pomgnt1 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 96%202430 Translocation of ZAP-70 to Immunological synapse Cd3g Ptpn22 Cd3e Cd3d Lck Zap70 H2-Eb1 Cd4 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 96%5660668 CLEC7A inflammasome pathway Pycard Il1b Rela Nfkb1 Casp8 Malt1 G2 PHASE%REACTOME DATABASE ID RELEASE 96%68911 G2 Phase E2f1 Ccna1 Ccna2 E2f3 Cdk2 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding Rgs11 Cct6a Gng10 Rgs9 Rgs6 Gng3 Rgs7 Gng2 Cct3 Cct2 Gng4 Gng7 Gng8 Tcp1 Gngt1 Gngt2 Cct6b Gna11 Gna15 Gna14 Csnk2a2 Gnb2 Gnaq Gnb1 Gnb4 Pdcl Gnb3 Gnb5 Cct8 Gng11 Cct7 Cct5 Gng12 Cct4 Gng13 Csnk2b INHIBITION OF MEMBRANE REPAIR%REACTOME DATABASE ID RELEASE 96%9635644 Inhibition of membrane repair Hgs NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 Nrg3 Cxcl12 Apoe Tab2 Esr1 Stat5a Pgr Ereg Csn2 Hbegf Stmn1 Btc Adap1 Ncor1 Mxd4 Adam17 Sparc Src Gfap S100b Wwox Nrg1 Psen1 Psen2 Ncstn Aph1b Yap1 Nrg2 Nrg4 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 Abcb11 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Cdkn2a Cdk4 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-HSA-3301854.4 Nuclear Pore Complex (NPC) Disassembly Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Cdk1 Nup214 Nup210 Nup155 Nup153 Nek9 Ccnb2 Nek6 Nup85 Nek7 Nup37 Sec13 Nup160 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166665 Terminal pathway of complement C9 C8b C8a C5 C8g Clu C6 C7 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells Ephb4 Ephb6 Efnb1 Efnb2 Efnb3 Efna4 Tiam1 Vav2 Efna5 Mmp9 Ephb2 Epha1 Fyn Clta Ap2m1 Cltc Adam10 Lyn Yes1 Ap2a2 Cltb Ap2a1 Epha2 Ap2b1 Psen1 Psen2 Ncstn Ap2s1 Aph1b Rac1 Efna1 Efna2 Efna3 Mmp2 Epha3 Epha4 Epha5 Epha6 Dnm1 Epha7 Epha8 Ephb1 Vav3 Ephb3 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events H2bc9 H2bc7 H2bc8 H2bc3 Nup133 Elk1 Ncor2 Nfkb1 H2bu2 Cbx1 Gps2 H2bc18 Egfr Daxx Hist2h2aa1 Nup37 Nup160 Eed Nup43 Ranbp2 H2bc14 Nup93 H2ac20 Nup50 Nup35 Dync1li2 Nup54 Pom121 Nup205 Dync1li1 Nup188 Tpr H2bc21 Nup107 Rae1 Ndc1 H2bc26 Nup42 Nup62 Rbbp4 Nup88 Ncor1 Dynll1 Rbbp7 Trim28 Dynll2 Aaas Nup214 Nup210 Nup155 Nup153 Tbl1x H2ac12 H2ac11 Dync1h1 Hdac3 H2ac15 H2ac21 H3c7 Ezh2 H2ac25 Tbl1xr1 Hist1h2af Nup85 Suz12 H2ac1 Dync1i2 Itgb1 Dync1i1 Hist1h2bp Pml Sec13 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 96%156588 Glucuronidation Ugt2a3 Ugt2b1 Ugp2 Ugdh Slc35d1 Ugt1a6 Ugt1a9 Uxs1 Ugt3a2 Ugt1a5 Abhd10 Ugt1a1 Ugt2b38 Ugt2b36 Ugt2b34 Slc35d2 Ugt1a2 Ugt2a1 Ugt2a2 MASITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669924 Masitinib-resistant KIT mutants Kit GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle Slc1a1 Slc1a3 Slc1a2 Rab3a Slc38a2 Cplx1 Arl6ip5 Unc13b Slc1a7 Slc1a6 Gls2 Gls Snap25 Syt1 Ppfia2 Ppfia4 Vamp2 Ppfia1 Stx1a DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 Ggcx F9 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-HSA-110320.3 Translesion Synthesis by POLH Pcna Rfc4 Rpa2 Rfc1 Rfc2 Vcp Ufd1 Rpa3 Nploc4 Polh Ubc Sprtn Rchy1 Rfc5 Rfc3 Rpa1 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%6787639 GDP-fucose biosynthesis Gmds Slc35c1 Fpgt Gfus Fuom Fcsk FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation Fcgr1 Yes1 Cd3g Fyn Fcgr3 Fcgr4 Syk Fgr Hck Lyn PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism Hgd Tat Fah Hpd Gstz1 Qdpr Pah Asrgl1 Pcbd1 Kyat1 Il4i1 MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling Crkl Rab4a Gab1 Gga3 Rab4b Crk Hgf Met Arf6 LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling Mttp Apof P4hb Apob MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation Supv3l1 Pnpt1 Fastkd2 Grsf1 Fastkd5 Tbrg4 Rexo2 Slirp Lrpprc BIOSYNTHESIS OF MARESINS%REACTOME%R-HSA-9018682.3 Biosynthesis of maresins Alox5 Ephx2 Cyp1a2 Cyp2d22 Cyp3a16 Cyp2c65 Cyp2e1 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation Vars2 Ears2 Wars2 Aars2 Rars2 Pars2 Ppa2 Lars1 Mars2 Dars2 Yars2 Eef1e1 Sars2 Hars2 Fars2 Kars1 Sars1 Wars1 Aars1 Hars1 Tars1 Yars1 Cars1 Nars1 Vars1 Mars1 Farsa Farsb Dars1 Qars1 Rars1 Aimp2 Aimp1 Eprs1 Iars1 Ppa1 Gars1 Lars2 Nars2 Tars2 Iars2 Cars2 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 96%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Pdcd4 Pitpna Ppia Rap1b Capza1 Cnn2 Pak2 Ifng Hspa9 Msn Hnrnpf Sod2 Lmnb1 Arf1 Tcp1 Il10 Psme2 Ca1 Taldo1 Snrpa1 Anxa2 Bola2 Stat4 Gsto1 Hnrnpa2b1 Serpinb2 Aip Mtap Cfl1 Mif Hnrnpdl Rala Lcp1 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors Cited2 Pitx2 Tfap2c Tfap2a AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 Prkaca Ccp110 Alms1 Cetn2 Nedd1 Actr1a Tuba1a Tpx2 Cep43 Dctn2 Cep41 Dctn3 Plk1 Ninl Ywhae Cdk1 Nek2 Pcnt Tuba4a Cep250 Sdccag8 Cep78 Cep76 Cep72 Cep70 Tubb5 Plk4 Cpap Clasp1 Ywhag Pafah1b1 Cep135 Cep131 Prkar2b Csnk1e Tubb4b Haus7 Tubb4a Haus8 Cdk5rap2 Cep57 Pcm1 Mapre1 Aurka Dynll1 Ssna1 Tubg1 Ppp2r1a Ofd1 Dync1h1 Hmmr Cep63 Cep152 Haus3 Haus4 Haus5 Haus6 Sfi1 Dync1i2 Csnk1d Haus1 Ckap5 Haus2 Akap9 Hsp90aa1 Cep164 ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Ccne1 Ccne2 Fzr1 Tfdp2 Tfdp1 Skp2 Rb1 Ccnd2 Ccnd3 Ccnd1 Cdk6 Cdk4 Cdk2 E2f1 E2f2 E2f3 Cdkn1a Cdkn1b Cdkn1c DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a Pmm2 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression Psma4 Jun Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Rela Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 H2ac20 Prkaa1 Prkaa2 Myc Erlin2 Erlin1 Atf3 Jund Rpn2 Rpn1 Hif1a Tcf7l1 Tcf7l2 Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 Ezh2 H2ax B3gnt3 Csnk2a2 Tead4 Suz12 Nfkb2 Ash2l Hist1h2bp Jak1 Fos H2aj Os9 Yap1 Sel1l Fosb Magt1 Brd4 H2bc9 H2bc7 Cul3 H2bc8 H2bc3 Mib2 Tead3 Tead2 Tead1 Stat3 Tmem258 Stat1 H2ab2 Rnf185 Mycn Derl3 Nek2 Derl2 Derl1 H2bu2 Stt3a Stt3b Spop Ctnnb1 Vcp Tcf7 Ostc Prkag3 Ccnd1 Prkag1 Prkag2 Cdk4 Cops5 Wwtr1 Tusc3 Kmt2c Hist2h2aa1 Erlec1 Dad1 Ywhag Epas1 Dpy30 Wdr5 Ddost Csnk2b Eed Cd274 Gsk3b Irf1 Lef1 H2bc14 Pdcd1 Rnf5 H2bc21 Tnrc6c H2bc26 Rbbp5 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Pdcd1lg2 Prkab2 Ep300 Prkab1 Nfe2l2 Crebbp SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 96%186797 Signaling by PDGF Col4a1 Col4a2 Stat6 Col9a2 Plat Col9a3 Rasa1 Col6a6 Nras Plcg1 Col6a3 Ptpn12 Col4a5 Rapgef1 Col9a1 Sos1 Stat5a Crk Stat5b Hras Nck2 Ptpn11 Plg Nck1 Bcar1 Pdgfrb Stat3 Stat1 Pdgfd Spp1 Thbs3 Thbs4 Pdgfb Thbs2 Src Grb7 Pdgfra Pik3cb Pik3ca Furin Crkl Col6a1 Col4a3 Pik3r1 Thbs1 Pik3r2 Col6a2 Col4a4 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation Fgfr4 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654727 Negative regulation of FGFR2 signaling Fgf16 Ppp2cb Frs2 Ppp2ca Fgf18 Fgf2 Fgf1 Fgf4 Fgf10 Fgf3 Fgf6 Fgf7 Fgf9 Fgf20 Ptpn11 Fgf23 Fgf22 Spry2 Ppp2r1a Mknk1 Cbl Ubc Mapk1 Braf Mapk3 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%419812 Calcitonin-like ligand receptors Calca Ramp3 Iapp Ramp2 Calcr Adm2 Calcrl Adm Ramp1 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling Rasgrp2 Fgb Fga Rap1b Vwf Rasgrp1 Fgg Itgb3 Sos1 Crk Tln1 Fn1 Bcar1 Csk Itga2b Akt1 Src Shc1 Ptpn1 Syk Ptk2 Rapgef4 Rapgef3 Rap1a Pdpk1 Apbb1ip DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane F8 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME%R-HSA-9629232.3 Defective Base Excision Repair Associated with NEIL3 Neil3 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 96%4720454 Defective ALG9 causes CDG-1l Alg9 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME DATABASE ID RELEASE 96%9664323 FCGR3A-mediated IL10 synthesis Cd3g Prkaca Prkar2b Itpr3 Itpr2 Itpr1 Plcg1 Prkx Plcg2 Fyn Prkar1a Prkacb Lyn Yes1 Prkar2a Adcy3 Il10 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Ahcyl1 Fcgr1 Adcy9 Fcgr3 Fcgr4 Syk Fgr Hck Prkar1b PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-HSA-3215018.5 Processing and activation of SUMO Ube2i Senp1 Sumo3 Senp2 Uba2 Sae1 Senp5 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 96%9793242 SUMOylation of nuclear envelope proteins Ube2i EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events Vhl Pik3c3 Nrp1 Havcr1 Ace2 Gpc1 Tmprss2 Chmp2a Gpc3 Gpc2 Pik3r4 Hspg2 Gpc5 Sdc4 Sdc3 Gpc4 Chmp3 Sdc2 Ddx5 Gpc6 Chmp7 Chmp6 Vcp Chmp4c Chmp4b Rb1 Sdc1 Map1lc3b Furin Agrn Becn1 Uvrag Iscu Zcrb1 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling Itgb3bp Net1 Arhgef10l Vav2 Prex1 Trio Mcf2 Mapk8 Tiam2 Ikbkb Arhgef15 Arhgef19 Mag Lingo1 Ngef Omg Arhgef9 Rtn4 Bcl2l11 Arhgef7 Ywhae Arhgef6 Ngfr Bex3 Arhgef4 Sqstm1 Nfkb1 Gna13 Fgd2 Rasgrf2 Fgd1 Fgd4 Arhgef37 Fgd3 Arhgef39 Arhgef38 Arhgef40 Plekhg5 Plekhg2 Rela Casp3 Ubc Aatf Irak1 Nfkbia Traf6 Prdm4 Ngf Tiam1 Sos1 Rhoa Hdac2 Hdac1 Abr Arhgef18 Prkci Ripk2 Myd88 Sos2 Mcf2l Arhgdia Adam17 Arhgef16 Bad Hdac3 Arhgef17 Arhgef11 Arhgef10 Smpd2 Arhgef26 Psen1 Itsn1 Psen2 Ncstn Rac1 Akap13 Aph1b Casp2 Kalrn Vav1 Arhgef3 Arhgef2 Arhgef1 Maged1 Ect2 Vav3 INTERLEUKIN-15 SIGNALING%REACTOME%R-HSA-8983432.5 Interleukin-15 signaling Jak3 Il2rb Sos1 Il15ra Stat5a Stat5b Gab2 Grb2 Shc1 Stat3 Jak1 Il2rg Sos2 Il15 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes Cox8a Higd1c Cox7b Prdx2 Prdx1 mt-Co2 mt-Co3 Trp63 Ywhae Gpi Txn Tigar Cox5a Cox6a1 Cox6a2 Prkag3 Prkag1 Prkag2 Ywhab Ywhag Rptor Slc38a9 Trp53 Lamtor5 Lamtor4 Rraga Mlst8 Cox6b1 Rragb Sesn2 Cox6b2 Coxfa4 Lamtor1 Rragc Sesn3 Rrm2b Lamtor2 Ywhah Rragd Tsc2 Mtor Tsc1 Prkaa1 mt-Co1 Prkaa2 Txnrd1 Akt3 Akt2 Tnrc6c Akt1 Cox4i1 Cox4i2 Tnrc6a Tnrc6b Prkab2 Prkab1 Ywhaz Mov10 G6pdx Ago4 Pten Ago3 Ago2 Ago1 Gpx2 Gls2 Gls Cox7a1 Cox7a2 Sfn Ddit4 Cox7a2l CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 96%380287 Centrosome maturation Prkaca Ccp110 Alms1 Cetn2 Tubgcp2 Nedd1 Tubg2 Actr1a Nme7 Tuba1a Tubgcp5 Tubgcp4 Tubgcp3 Cep43 Mzt1 Dctn2 Mzt2 Cep41 Dctn3 Plk1 Ninl Ywhae Cdk1 Nek2 Pcnt Tuba4a Cep250 Sdccag8 Cep78 Cep76 Cep72 Cep70 Tubb5 Plk4 Cpap Clasp1 Ywhag Pafah1b1 Cep135 Cep131 Prkar2b Csnk1e Tubb4b Haus7 Tubb4a Haus8 Cdk5rap2 Cep57 Pcm1 Mapre1 Dynll1 Ssna1 Tubg1 Cdk11b Ppp2r1a Ofd1 Dync1h1 Cep63 Cep152 Haus3 Haus4 Haus5 Haus6 Sfi1 Dync1i2 Csnk1d Haus1 Ckap5 Haus2 Akap9 Hsp90aa1 Cep164 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers Ss18 Actl6a Dpf1 Actl6b Dpf2 Smarce1 Dpf3 Ss18l1 Bcl7a Bcl7b Bcl7c Smarcb1 Bicral Pbrm1 Bicra Brd9 Bcl11a Smarca2 Smarca4 Actb Smarcd1 Smarcd2 Bcl11b Phf10 Smarcc2 Smarcc1 Arid1a Arid1b Smarcd3 Brd7 Arid2 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%212676 Dopamine Neurotransmitter Release Cycle Rab3a Slc18a2 Cplx1 Unc13b Cask Apba1 Syn3 Syn2 Lin7a Syn1 Lin7b Snap25 Lin7c Syt1 Ppfia2 Ppfia4 Vamp2 Ppfia1 Stx1a CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels Kcnmb2 Kcnmb1 Kcnn4 Kcnma1 Kcnn3 Kcnn2 Kcnn1 Kcnmb4 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses Dlg1 Dlg3 Dlg4 Gria4 Gria3 Gria1 Cask Syt9 Ntrk3 Grm1 Lin7a Grm5 Lin7b Lin7c Flot2 Flot1 Stxbp1 Homer1 Homer2 Begain Homer3 Ptprs Ptprf Sipa1l1 Dlgap1 Apba2 Apba1 Apba3 Dlgap4 Dlgap3 Il1rapl1 Il1rapl2 Nrxn1 Nrxn2 Ppfibp2 Ppfibp1 Epb41l2 Epb41l3 Epb41l5 Lrfn2 Lrfn3 Lrfn4 Lrrc4b Syt7 Shank1 Shank3 Syt12 Sharpin Pdlim5 Epb41 Slitrk6 Slitrk4 Slitrk1 Syt10 Slitrk2 Dbnl Lrrtm1 Lrrtm2 Lrrtm3 Grin2b Slitrk5 Nlgn2 Slitrk3 Nlgn1 Nlgn3 Syt2 Syt1 Grin2a Stx1a Dlg2 Grin1 Grin2d Grin2c Ppfia2 Ppfia4 Ppfia1 Rtn3 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717323 ceritinib-resistant ALK mutants Alk RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013422 RHOBTB1 GTPase cycle Cpsf7 Hnrnpc Rock2 Rhobtb1 Rock1 Vim Rnf20 Cul3 Dbn1 Spen Pde5a Cct2 Myo6 Txnl1 Rbmx Srrm1 Cops4 Cct7 Tra2b Cops2 Stk38 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-HSA-2029480.3 Fcgamma receptor (FCGR) dependent phagocytosis Cd3g Elmo2 Pak1 Itpr3 Vav2 Itpr2 Itpr1 Plcg2 Cyfip1 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Btk Actg1 Actb Myo5a Hsp90ab1 Arpc3 Arpc2 Cyfip2 Arpc5 Arpc4 Pld2 Pik3cb Limk1 Fcgr1 Pik3ca Fcgr3 Mapk1 Fcgr4 Syk Ptk2 Mapk3 Fgr Myh2 Brk1 Myo1c Nckipsd Pla2g6 Was Wasf3 Baiap2 Nckap1l Wasl Plcg1 Myo10 Crk Nckap1 Nck1 Fyn Wasf2 Wasf1 Abl1 Abi2 Myo9b Abi1 Prkce Lyn Yes1 Pld4 Prkcd Myh9 Ahcyl1 Plpp4 Plpp5 Rac1 Pld3 Vav1 Elmo1 Hck Nf2 Hsp90aa1 Pik3r1 Cfl1 Pik3r2 Pld1 Vav3 Dock1 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9615710 Late endosomal microautophagy Plin3 Chmp2a Hdac6 Ift88 Arl13b Chmp3 Chmp7 Chmp6 Cftr Cetn1 Pcnt Plin2 Ubap1 Rnase1 Tsg101 Chmp4c Park7 Mvb12a Chmp4b Mvb12b Vps37a Vps37b Vps37c Vps37d Hspa8 Ubc Hbbt1 Vps28 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447038 NrCAM interactions Nrcam Dlg1 Dlg3 Cntn2 Dlg4 Ank1 Nrp2 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 96%192105 Synthesis of bile acids and bile salts Amacr Abcb11 Acox2 Rxra Slc27a5 Baat Akr1c18 Acot8 Hsd17b4 Cyp8b1 Osbpl1a Ncoa2 Slc27a2 Ncoa1 Osbp Cyp39a1 Ch25h Osbpl3 Cyp46a1 Osbpl2 Osbpl7 Osbpl6 Osbpl9 Nr1h4 Akr1c21 Hsd3b7 Cyp27a1 Akr1d1 Cyp7a1 Cyp7b1 Akr1c6 DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) Slc35a1 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 96%5576894 Phase 1 - inactivation of fast Na+ channels Kcnd3 Kcnd2 Kcnd1 Kcnip4 Kcnip1 Kcnip3 MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion Adar Adarb1 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9840309 Glycosphingolipid biosynthesis B4galt6 B4galnt1 Fut2 Ugt8 Fut1 St6galnac5 Gal3st1 St3gal5 A4galt St3gal2 Cerk B3gnt5 St6galnac6 St8sia5 B3galnt1 Ugcg B3galt4 B4galt5 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Chrna3 Chrnb4 Chrna2 Chrnb3 Chrnb2 Chrna1 Chrna6 Chrna5 Chrna4 Chrna9 APOPTOSIS%REACTOME%R-HSA-109581.6 Apoptosis Tlr4 Apaf1 Bmx Ppp3r1 Psma4 Psma3 Psma6 Psma5 Birc2 Psma2 Psma1 Tradd Ticam2 Traf2 Ticam1 Trp63 Bcl2l11 Psmd12 Cd14 Psmd11 Ywhae Psmd14 Xiap Fasl Fnta Psmd13 Tnfsf10 Psmb5 Psmb4 Lmnb1 Tnfrsf10b Psmb7 Psmb6 Fadd Psmb1 Psmb3 Gzmb Psmb2 Dsp Psma7 Tjp1 Psmc6 Bak1 Casp3 Pkp1 Psmc5 Casp8 Dsg2 Psmc2 Dsg3 Psmc1 Dsg1a Ripk1 Psmc4 Psmc3 Tjp2 Ubc Gsdme Gsdmd Psmd7 Psmd6 Ptk2 Bax Psmd8 Fas Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Prkcq Aven Sptan1 Uaca Trp73 Diablo Satb1 Trp53 Gsn Casp7 Gas2 Ywhah Dbnl Add1 Plec Akt3 Dcc Akt2 Akt1 Kpna1 Hmgb2 Dffa Dffb Ywhaz Casp9 Bad Nmt1 Casp6 Sfn Kpnb1 Maged1 Dapk1 Unc5b Dapk2 Unc5a Dapk3 Appl1 Apip Pak2 Mapk8 H1f2 H1f3 Cdkn2a Stat3 Bid Ctnnb1 Tfdp2 H1-1 Tfdp1 Rock1 H1-0 Vim Cdh1 H1-5 H1-4 Ppp1r13b E2f1 Mapk1 Mapk3 Ywhab Ywhag Bcap31 Trp53bp2 Bcl2 Bcl2l1 Dynll1 Dynll2 Clspn Stk26 Stk24 Oma1 Dnm1l Opa1 Apc Acin1 C1qbp Prkcd Arhgap10 Bmf Ppp3cc Ly96 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer Cdc37 Nras Gab1 Plcg1 Cbl Sos1 Hras Egfr Ubc Pik3ca Egf Tgfa Shc1 Ereg Areg Hbegf Btc Epgn Hsp90aa1 Pik3r1 SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions Fgfr2 DARPP-32 EVENTS%REACTOME%R-HSA-180024.6 DARPP-32 events Ppp2cb Prkar2a Prkaca Ppp1r1b Ppp2ca Prkar2b Pde4a Pde4c Pde4d Ppp3r1 Ppp3ca Ppp3cb Ppp3cc Prkar1a Ppp2r5d Cdk5 Ppp1ca Prkacb Prkar1b Ppp2r1b Ppp2r1a FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 96%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface Fcn2 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%R-HSA-3323169.4 Defects in biotin (Btn) metabolism Acaca Btd Mccc1 Pcx Pcca Mccc2 Pccb Hlcs INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida Zp2 Ovgp1 Hyal5 B4galt1 Adam30 Adam21 Adam2 Zp1 Zp3 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME%R-HSA-9958810.1 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) Jup Src Tiam1 Ctnnb1 Vav2 Cbll1 Ctnnd1 Cdh1 Ctsb Ubc Ctss Rac1 Elmo1 Ctnna1 Arhgef4 Farp2 Cdh11 Dock1 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) Ltc4s Ephx2 Cyp1a2 Alox12 Hpgd Alox5 Lta4h Ptgs2 Alox5ap Cyp2d22 Alox15 Cyp3a16 Cyp2c65 Gstm4 Cyp2e1 Cyp1a1 Ptgr1 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037629 Lewis blood group biosynthesis Fut2 St3gal6 St6galnac6 Fut4 B3galt2 Fut7 B4galnt2 Fut9 B3galt1 B3galt5 St3gal4 B3galt4 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand Tlr7 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Ss18 Actl6a Dpf1 Actl6b Dpf2 Smarce1 Dpf3 Ss18l1 Bcl7a Bcl7b Bcl7c Smarcb1 Bcl11a Smarca2 Smarca4 Actb Smarcd1 Smarcd2 Bcl11b Phf10 Smarcc2 Smarcc1 Arid1a Arid1b Smarcd3 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 96%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Aim2 App Ikbkb Birc3 Birc2 Ikbkg Map3k7 Nfkb1 Aamp Txn Hsp90ab1 Nlrp3 Nlrp1a Pstpip1 Rela Itch Casp8 Casp4 Casp1 Mefv Mapk12 Irak1 Mapk13 Traf6 Ube2n Mapk14 Chuk Map2k6 Pycard Ube2v1 Tab3 Tab2 Tab1 Sugt1 P2rx7 Cyld Tnfaip3 Mapk11 Ripk2 Bcl2 Bcl2l1 Hmox1 Casp9 Nod2 Nod1 Nlrc4 Card9 Panx1 Irak2 Nfkb2 Casp2 Txnip MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 96%68882 Mitotic Anaphase Tuba1b Tuba1a Ankle2 Tuba1c Tubal3 Chmp2a Tubb2b Chmp3 Tubb2a Chmp7 Chmp6 Lmnb1 Tuba4a Chmp4c Chmp4b Ppp2r2a Tuba8 Tuba3b Tubb6 Tubb3 Tubb1 Tubb4b Tubb4a Nup93 Nup35 Nup54 Pom121 Nup205 Nup188 Ndc1 Nup62 Banf1 Nup155 Kpnb1 Ran Clasp1 Clasp2 Pafah1b1 Smc3 Nup37 Zw10 Nup160 Cdc20 Ppp2cb Ppp2ca Clip1 Nup43 Knl1 Mad2l1 Sgo1 Ranbp2 Bub1b Kif2a Rad21 Kif2b Kif2c Dync1li2 Pmf1 Wapl Ska1 Dync1li1 Ahctf1 Nup107 Dsn1 Mapre1 Zwint Dynll1 Dynll2 Rps27 Rcc2 Kntc1 Stag2 Stag1 Ppp2r1b Ppp2r1a Pds5b Pds5a Ndc80 Kif18a Nudc Dync1h1 Birc5 Spc24 Spc25 Ercc6l Nuf2 Ccnb2 Nup85 Cdca8 Incenp Cdca5 Dync1i2 Ndel1 Dync1i1 Ckap5 Aurkb Cenpa Spdl1 Ppp2r5d Ppp2r5c Ppp2r5b Nsl1 Ppp2r5a Sec13 B9d2 Bub3 Bub1 Ppp1cc Taok1 Cenpc1 Sgo2b Itgb3bp Mad1l1 Cenpu Cenpt Cenps Cenpq Cenpp Ppp2r5e Psma4 Cenpo Cenpn Spast Psma3 Cenpm Espl1 Psma6 Mis12 Psma5 Lemd2 Nup133 Psma2 Cenpl Cc2d1b Psma1 Ist1 Zwilch Cenpk Vrk1 Cenpi Sirt2 Cenph Psmd12 Psmd11 Smc1a Cenpf Psmd14 Cenpe Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Ube2i Pttg1 Rcc1 Vps4a Tnpo1 Plk1 Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdk1 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Cdc23 Anapc15 Emd Lemd3 Lbr Xpo1 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 96%5627123 RHO GTPases activate PAKs Mylk Myl6 Pak1 Cttn Pak3 Myh14 Pak2 Myh10 Myh9 Limk1 Myl12a Ppp1r12b Ppp1r12a Myl12b Rac1 Myh11 Nf2 Ppp1cb Flna RHOBTB3 ATPASE CYCLE%REACTOME%R-HSA-9706019.5 RHOBTB3 ATPase cycle Ccne1 Plin3 Rab9b Vhl Rab9 Hgs Cul3 Lrrc41 Rhobtb3 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 Fgf23 Fgf22 Fgf2 Fgf1 Fgf4 Plcg1 Fgf10 Fgf3 Fgf6 Fgf9 Fgf20 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 96%1482798 Acyl chain remodeling of CL Tafazzin Pla2g4a Hadha Hadhb Lclat1 Pla2g6 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 96%1169410 Antiviral mechanism by IFN-stimulated genes Adar Oas3 Cenps Dhx9 Eif4g2 Ikbkb Eif4g3 Pim1 Eif4e3 Nup133 Eif2s3x Ikbkg Eif2s2 Eif2s1 Fancc Fnta Fntb Actb Sphk1 Npm1 Casp1 Ubc Becn1 Cenpx Ube2n Chuk Uba7 Trp53 Ptpn2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Ube2i Nck1 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Ppm1b Nup88 Kpna1 Aaas Nup214 Nup210 Nup155 Nup153 Eif2ak2 Jak1 Sfn Kpnb1 Kpna4 Kpna7 Kpna3 Abce1 Isg15 Dnajc3 Stat3 Stat1 Cdk1 Arih1 Actg1 Hspa1a Ube2e1 Trim25 Mavs Rigi Oas2 Gbp2 Gbp3 Hspa8 Mapk3 Furin Nup37 Eif4g1 Nup160 Map2k6 Ppp2cb Ppp2ca Nup43 Ranbp2 Plcg1 Pin1 Eif4e Gbp5 Eif4a2 Nup107 Eif4a1 Pde12 Irf3 Snca Oas1g Ppp2r1b Ppp2r1a Fancl Fancm Fanca Fancb Rnasel Fance Fancf Eif4a3 Fancg Nedd4 Pggt1b Hspa1l Nup85 Dus2 Ifit1bl2 Ube2l6 Usp18 Faap24 Prkra Faap20 Tarbp2 Ilf2 Flnb Oasl1 Ilf3 Flna Faap100 Ppp2r5a Sec13 Hspa2 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 96%71288 Creatine metabolism Slc6a7 Ckm Ckmt1 Ckmt2 Ckb Slc6a8 Slc6a11 Gamt Slc6a12 Gatm ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%8939211 ESR-mediated signaling Sp1 Mmp9 Prmt1 Jun Tgfa Ebag9 Cxxc5 Smc1a Tle3 Kdm1a Greb1 Ddx5 Fkbp5 Ctsd Kdm4b Foxo3 Kank1 Pou2f1 Fkbp4 Chd1 Tff3 Zfp217 Sphk1 Foxa1 Ncoa3 Usf1 Usf2 Nr5a2 Kctd6 Polr2c Polr2d Polr2a Polr2b Polr2g Ptk2 Polr2h Polr2e Polr2f Polr2k Gnai2 Gnai1 Polr2i Gnai3 Polr2j Esr2 Gtf2f2 Gtf2f1 Gnat3 Cxcl12 Gng10 Esr1 H2ac20 Hdac1 Myc Nos3 Akt3 Pgr Akt2 Gng3 Akt1 Gng2 Kat5 Gng4 Jund Strn Gng7 Gng8 Mov10 H2ac12 H2ac11 Ago4 Ago3 Gngt1 Ago2 Gngt2 Ago1 H2ac15 H3c7 H2ax Myb Cav1 Hist1h2bp Gnb2 Fos Gnb1 Gnb4 H2aj Gnb3 Gnb5 Gng11 Hsp90aa1 Pik3r1 Gng12 Pik3r2 Gng13 Axin1 Gata3 Fosb Cited1 H2bc9 H2bc7 H2bc8 H2bc3 Elk1 Ereg Hbegf Btc Epgn Uhmk1 H2ab2 Mmp3 Yy1 Hsp90ab1 H2bu2 Src Igf1r Cbfb Ccnd1 Egfr Pik3ca Kat2b Mapk1 Mapk3 Hist2h2aa1 Cdkn1b Pdpk1 Smc3 Nras H2bc14 Rad21 Hras Prkcz Egf Bcl2 H2bc21 Tnrc6c Areg H2bc26 Atf2 Tnrc6a Tnrc6b Carm1 Nrip1 Stag2 Stag1 Srf Ep300 Ppp5c S1pr3 Tbp Ncoa2 Ncoa1 Xpo1 Gtf2a1 Gtf2a2 Med1 Cdk9 Mmp2 Zdhhc7 Ccnt1 Crebbp Zdhhc21 Ppid Cav2 Mmp7 Gpam P75NTR SIGNALS VIA NF-KB%REACTOME%R-HSA-193639.3 p75NTR signals via NF-kB Ngf Rela Ikbkb Ubc Prkci Ripk2 Myd88 Ngfr Irak1 Nfkbia Sqstm1 Nfkb1 Traf6 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 96%379398 Enzymatic degradation of Dopamine by monoamine oxidase Maoa Comt EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects Cdkn2a RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 96%5626467 RHO GTPases activate IQGAPs Clip1 Rac1 Ctnnb1 Ctnna1 Iqgap2 Cdh1 Men1 Iqgap1 Iqgap3 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression Ppp2cb Ppp2ca Ppp2r2d Arpp19 Cdk1 Mastl Ppp2r1b Ensa Ppp2r1a ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111448 Activation of NOXA and translocation to mitochondria E2f1 Trp53 Tfdp2 Tfdp1 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669934 Sunitinib-resistant KIT mutants Kit TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 96%8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors Myc Cdkn1a Tfap2c Tfap2a Kdm5b PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622323 Presynaptic nicotinic acetylcholine receptors Chrnd Chrne Chrng Chrna3 Chrnb4 Chrna2 Chrnb3 Chrnb2 Chrna1 Chrna6 Chrna5 Chrna4 SIGNALING BY AXIN MUTANTS%REACTOME%R-HSA-4839735.5 Signaling by AXIN mutants Ppp2cb Ppp2ca Gsk3b Csnk1a1 Ppp2r5e Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Amer1 Ppp2r1b Apc Ppp2r1a Axin1 CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948001 CASP4 inflammasome assembly Serpinb1a Casp4 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 96%3359473 Defective MMADHC causes MMAHCD Mmadhc Mmachc HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 96%1638091 Heparan sulfate heparin (HS-GAG) metabolism Glce Sgsh Hpse Hs2st1 Ndst1 Gpc1 Ndst2 Idua Ndst3 Gpc3 Ndst4 Gpc2 Hspg2 Slc35d2 Gpc5 Sdc4 Sdc3 Gpc4 Sdc2 Hs3st3b1 Gpc6 Ids Hs6st3 Hs6st2 Hs6st1 Hs3st3a1 Ext2 Ext1 Extl2 Sdc1 Naglu Hs3st4 Hs3st1 Extl3 Hs3st2 Hs3st5 Hs3st6 Agrn Hpse2 CYTOPROTECTION BY HMOX1%REACTOME%R-HSA-9707564.6 Cytoprotection by HMOX1 Blvra Cox8a Higd1c Cox7b mt-Co2 Ncor2 mt-Co3 Stat3 Fabp1 Cox5a Nlrp3 Cox6a1 Cox6a2 Hmox2 Ptk6 Alb Abcc1 Cox6b1 Cox6b2 Ppara Coxfa4 Rxra mt-Co1 Cox4i1 Cox4i2 Ncor1 Helz2 Carm1 Tbl1x Hmox1 Sin3a Hdac3 Ncoa2 Stap2 Ncoa1 Tbl1xr1 Smarcd3 Ncoa6 Hba-a1 Mafk Hbbt1 Med1 Cox7a1 Bach1 Cox7a2 H13 Txnip Nfe2l2 Crebbp Chd9 Blvrb Cox7a2l DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis Tradd Traf2 Mlkl Ripk3 Casp8 Ripk1 Fadd PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%1257604 PI3K AKT Signaling Rcor1 Jun Pip5k1b Pip5k1a Xiap Kdm1a Sgk1 Foxo3 Stub1 Irak1 Esr2 Trp53 Rnf146 Tnks2 Tnks Trim27 Otud3 Wwp2 Usp13 Frk Casp9 Bad Mecom Il1rl1 Il33 Sall4 Ereg Hbegf Btc Epgn Mbd3 Ring1 Cbx8 Phc2 Cbx6 Phc1 Cbx4 Cbx2 Nrg1 Phc3 Mdm2 Egfr Cdkn1a Ier3 Cdkn1b Phlpp1 Bmi1 Phlpp2 Flt3 Rps6kb2 Atn1 Maf1 Klb Fgf16 Ppp2cb Rnf2 Fgf15 Ppp2ca Irs1 Fgf18 Irs2 Fgf2 Fgf1 Bdnf Gab1 Fgf4 Fgf10 Fgf3 Ntf4 Fgf6 Fgf7 Ntrk2 Fgf9 Fgf20 Ntf3 Hdac2 Gab2 Hdac5 Fgf23 Egf Fgfr4 Fgf22 Myd88 Hdac7 Areg Pdgfb Egr1 Ppp2r1b Ppp2r1a Pten Nedd4 Irak4 Ppp2r5d Ppp2r5c Ppp2r5b Cd19 Ppp2r5a Mkrn1 Insr Ppp2r5e Psma4 Foxo4 Psma3 Psma6 Foxo1 Psma5 Psma2 Tgfa Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Nr4a1 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Flt3l Mta1 Psma7 Mta3 Psmc6 Pip5k1c Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Traf6 Nrg2 Chuk Nrg4 Nrg3 Gsk3a Esr1 Pparg Trib3 Hdac1 Akt3 Akt2 Akt1 Strn Kit Mov10 Chd3 Chd4 Ago4 Ago3 Nr2e1 Ago2 Ago1 Ezh2 Rest Snai2 Csnk2a2 Suz12 Cd28 Erbb2 Mta2 Rac1 Vav1 Pik3r5 Pik3r6 Pik3r1 Pik3r2 Pip4k2b Pip4k2a Rac2 Trat1 Pdgfrb Pik3ap1 Gatad2a Ntrk3 Gatad2b Rictor Cd86 Cd80 Src Pik3cg Pik3cb Pik3cd Hgf Met Pik3ca Mapk1 Mapk3 Prr5 Rptor Pdpk1 Csnk2b Frs2 Eed Them4 Usp7 Slc38a9 Lamtor5 Gsk3b Akt1s1 Lck Lamtor4 Rraga Mlst8 Rragb Lamtor1 Rragc Lamtor2 Rragd Tsc2 Mtor Ptpn11 Fyn Tnrc6c Rbbp4 Rbbp7 Atf2 Tnrc6a Tnrc6b Mapkap1 Rhog Hdac3 Pdgfra Snai1 Pml Ins2 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 96%983705 B Cell Activation Cd22 Fkbp1a Stim1 Nfatc1 Nfatc3 Ppia Nfatc2 Itpr3 Rasgrp3 Itpr2 Rasgrp1 Itpr1 Ppp3r1 Ppp3ca Ppp3cb Psma4 Blnk Ikbkb Psma3 Psma6 Plcg2 Psma5 Cd79a Psma2 Cd79b Psma1 Ikbkg Pik3ap1 Map3k7 Psmd12 Psmd11 Psmd14 Btk Psmd13 Nfkb1 Skp1 Malt1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Fbxw11 Sh3kbp1 Rela Card11 Prkcb Btrc Psma7 Psmc6 Blk Psmc5 Psmc2 Psmc1 Pik3cd Psmc4 Dapp1 Psmc3 Ubc Bcl10 Psmd7 Psmd6 Nfkbib Syk Nfkbie Psmd8 Psmd3 Psmd2 Psmd1 Nfkbia Adrm1 Sem1 Cul1 Rel Chuk Nras Ptpn6 Sos1 Hras Nck1 Fyn Lyn Ahcyl1 Vav1 Cd19 Pik3r1 Trpc1 Orai1 Orai2 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA H2bc9 H2bc7 H2bc8 H2bc3 Elac2 Ang H2ab2 H2bu2 Ran Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Hist2h2aa1 Polr2e Polr2f Polr2k Polr2i Polr2j Ipo8 H2bc14 H2ac20 Henmt1 Asz1 H2bc21 Tdrd1 Tnrc6c Mov10l1 H2bc26 Tdrd12 Mybl1 Fkbp6 Piwil4 Tnrc6a Tnrc6b Tdrkh Piwil2 Piwil1 Tdrd9 Tdrd6 Ddx4 Mael H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 H2ax Dgcr8 Tsnax Hist1h2bp Prkra Dicer1 Tarbp2 Tsn H2aj Bcdin3d Drosha Hsp90aa1 Xpo5 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer Cdc37 Nras Gab1 Plcg1 Cbl Sos1 Hras Egfr Ubc Pik3ca Egf Shc1 Hsp90aa1 Pik3r1 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190242 FGFR1 ligand binding and activation Fgf23 Tgfbr3 Fgf22 Fgf2 Fgf1 Fgf4 Fgf10 Fgf3 Fgf6 Fgf9 Gipc1 Fgf20 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 96%69563 p53-Dependent G1 DNA Damage Response Psma4 Atm Psma3 Psma6 Psma5 Psma2 Psma1 Cdkn2a Psmd12 Psmd11 Phf20 Psmd14 Pcbp4 Psmd13 Chek2 Zfp385a Cop1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Ccne1 Psmb2 Ccne2 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Mdm2 Ubc Cdk2 Mdm4 Ccna1 Psmd7 Ccna2 Psmd6 Cdkn1a Psmd8 Cdkn1b Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Trp53 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis Hint1 Sin3a Ago4 Ago3 Ago2 Ago1 Pou3f2 Birc7 Trpm1 Hdac1 Bcl2a1d Bcl2 Tnrc6c Dicer1 Tnrc6a Tnrc6b Mov10 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 96%916853 Degradation of GABA Aldh5a1 Abat STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 96%2672351 Stimuli-sensing channels Trpc3 Ano7 Ano6 Trpa1 Ano5 Trpv1 Clcn6 Ano4 Trpv3 Ano2 Mcoln1 Ano1 Mcoln2 Ttyh3 Trpv2 Ttyh2 Trpc4ap Trpm2 Sgk3 Trpm1 Sgk2 Trpm8 Trpm7 Trpm4 Scnn1a Trpm3 Raf1 Scnn1b Trpm6 Unc79 Trpm5 Scnn1g Slc17a3 Ostm1 Tpcn1 Tpcn2 Clcn7 Clca4a Clcn4 Clcn5 Bsnd Sgk1 Ubc Nedd4l Wwp1 Asic5 Asic4 Asic1 Clcn2 Clcn3 Slc9c1 Clcn1 Ryr2 Fkbp1b Ryr1 Wnk4 Sri Trdn Nalcn Ryr3 Tsc22d3 Wnk1 Wnk3 Wnk2 Asph Slc9b1 Best1 Slc9b2 Best3 Clcnkb Best2 Stom Trpv5 Clcnka Trpv4 Clca1 Trpv6 Clca2 Trpc6 Trpc5 Trpc7 Stoml3 Mcoln3 Trpc1 Ano10 Trpc4 Ano8 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 96%1839120 Signaling by FGFR1 amplification mutants PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling Apoe Angptl8 Angptl4 Angptl3 Mttp Abcg1 Lcat Fgf21 Apoa2 Apoa4 Apoa5 Creb3l3 Lmf1 Lmf2 Lpl Gpihbp1 Apoc2 Furin Lipg Pcsk5 Lipc Pcsk6 Alb Mbtps1 Apoc3 Mbtps2 Apoa1 Apof P4hb Apob ANTIMICROBIAL PEPTIDES%REACTOME DATABASE ID RELEASE 96%6803157 Antimicrobial peptides Atox1 Cd4 Bpifb2 Lcn2 S100a9 Bpifb1 S100a8 Bpifb6 Bpi Bpifa1 Bpifa2 Defb47 Defb14 Prtn3 Defb36 Tlr1 Rnase6 Defb25 Defb15 Tlr2 Defb18 Defb29 Defb19 Defb23 Defb12 Eppin Elane Itln1 Ctsg Camp Chga Ltf Leap2 Clu Pdzd11 Rnase2b Ccr6 Prss2 Art1 Ccr2 Pglyrp2 Slc11a1 Pglyrp3 Pglyrp1 Pglyrp4 Atp7a Reg3b Reg3g DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 96%4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane Lrp6 Ppp2cb Lrp5 Ppp2ca Wnt8b Wnt8a Gsk3b Csnk1a1 Frat2 Ppp2r5e Frat1 Dvl1 Wnt3a Dvl2 Dvl3 Ppp2r1b Apc Ppp2r1a Wnt1 Fzd1 Ctnnb1 Fzd2 Fzd5 Cav1 Ppp2r5d Ppp2r5c Ppp2r5b Csnk1g2 Ppp2r5a Amer1 Axin1 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 96%111471 Apoptotic factor-mediated response Diablo C1qbp Apaf1 Apip Casp3 Bak1 Casp7 Gsdme Gsdmd Cdkn2a Mapk1 Bax Mapk3 Xiap Aven Uaca Casp9 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 96%174417 Telomere C-strand (Lagging Strand) Synthesis Rpa2 Rpa3 Tinf2 Dscc1 Lig1 Chtf18 Ctc1 Chtf8 Stn1 Ten1 Rfc5 Pold2 Pold1 Rfc3 Pcna Rfc4 Prim2 Rfc1 Prim1 Acd Rfc2 Pola2 Pold4 Pola1 Pold3 Dna2 Terf2ip Blm Terf2 Terf1 Wrn Fen1 Pot1 Rpa1 SARS-COV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%9678108 SARS-CoV-1 Infection Sp1 Fkbp1a Ppia Sting1 Chmp2a Traf3 Ywhae Ikbke Nfkb1 Chmp3 Ddx5 Chmp7 Chmp6 Nlrp3 Rela Itch Npm1 Ripk3 Chmp4c Chmp4b Psmc6 Casp1 Ubc Map1lc3b Becn1 Uvrag Nfkbia Parp14 Traf6 Parp16 Galnt1 Parp4 Parp6 Ganab Pycard Gsk3a Parp8 Parp10 Parp9 Mgat1 Mogs Smad3 Smad4 St6galnac3 St6galnac4 Ywhah St6galnac2 St3gal4 Ube2i St3gal2 St3gal1 Prkcsh St6gal1 Ywhaz Rps14 Rps16 Rps18 Rps19 Cav1 Rpsa Sfn Rps10 Kpnb1 Rps11 Zcrb1 Rps9 Rps7 Rps5 Vhl Rps25 Pcbp2 Rps26 Rps21 Nmi Ace2 Tmprss2 Rps15a Rps27l Sftpd Ifih1 Sike1 Trim25 Mavs Canx Rigi Rps3 Rps4x Vcp Rb1 Pals1 Tomm70 Ywhab Ywhag Pdpk1 Gsk3b Pik3c3 Rcan3 Tbk1 Bcl2l1 Irf3 Pik3r4 Rps27 Ep300 Hnrnpa1 Bst2 Tkfc Irak2 Tlr7 Ppig Ppih Ppib SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 96%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways Akt3 Cav1 Akt2 Akt1 Sfn Ywhae Ywhab Ywhag Pdpk1 Ywhah Ywhaz DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 96%4724325 Defective ALG8 causes CDG-1h Alg8 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 96%72203 Processing of Capped Intron-Containing Pre-mRNA Lsm5 Dnajc8 Rbm22 Lsm6 Lsm7 Rbm17 Ddx46 Ddx42 Sap18b Ddx23 Ppp1ca Ppp1cb Ddx5 Sympk Cstf1 Papola Clp1 Nudt21 Cpsf1 Xrn2 Cstf2 Cpsf2 Cstf3 Cpsf3 Cstf2t Wdr33 Ybx1 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Slbp Nup155 Nup153 Mtrex Cpsf4 Papolg Prpf40a Snrnp70 Htatsf1 Rbm7 Ppp1r8 Snrpa Snrpc Rbm25 Srsf10 Tut1 Ppp1r10 Tcerg1 Rbm39 Pabpn1 Hspa8 Nup37 Nup160 Nup43 Nxt1 Rnps1 Gle1 Ranbp2 Fyttd1 Srsf1 Thoc1 Thoc2 Thoc3 Thoc5 Thoc6 Thoc7 Srsf9 Ddx39a Cdc40 Nup107 Srsf7 Srsf6 Srsf3 Magoh Ddx39b Srsf2 Srsf11 Srrm1 Rbm8a Upf3b Zc3h11a Slu7 Poldip3 Acin1 Alyref Nxf1 Chtop Dhx38 U2af1l4 Nxf7 Eif4a3 Snrpb Casc3 Magohb Snrpd2 Snrpd1 Nup85 Snrpd3 Sec13 Ddx41 Dhx9 Ppil2 Nup133 Hnrnpu Znf830 Ubc Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 Mettl3 Prpf4 Leng1 Prpf3 Fam50a Prpf31 Mettl14 Zmat2 Cactin Pnn Rnf113a2 Sf1 Rbmx2 Nsrp1 Tfip11 Prpf18 Ik Dhx8 Wdr70 Snip1 Fam32a Steep1 Dhx35 Yju2 Smu1 Lsm8 Gpatch1 Ppwd1 Snrnp27 Gcfc2 Ccdc12 Ubl5 Syf2 Phf5a Prpf4b Sde2 Usp39 Crnkl1 Sart1 Wbp4 Cwf19l2 Mfap1b Prpf38a Prkrip1 Nkap Rbm42 Luc7l3 Bud13 Xab2 Hnrnpa2b1 Zcrb1 Prpf19 Puf60 Bcas2 Gpkow Smndc1 Aqr Pcbp2 Pcbp1 Hnrnpr Snrnp25 Zmat5 Sugp1 Snrnp48 Hnrnpd Snrnp35 Zrsr2 Hnrnpf Rnpc3 Hnrnpk Ccar1 Pdcd7 Hnrnpl Hnrnpm Rbmx Hnrnph2 Hnrnph1 Tra2b Cwc22 Cwc27 Cpsf7 Hnrnpc Cwc25 Cwc15 Rbm5 Txnl4a Fip1l1 Snrnp200 U2surp Snrpb2 Snrpa1 Ptbp1 Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Sf3b5 Sf3b6 Ctnnbl1 Srrt Snrnp40 Eftud2 Eif4e Snrpn Cherp Fus Isy1 Cdc5l Plrg1 Hnrnpa3 Ppil4 Ppil3 Hnrnpa1 Ppil1 Prcc Rbm10 Dhx16 Dhx15 Srrm2 Ncbp2 Ncbp1 Prpf6 Ppig Ppih Ppie Prpf8 Wbp11 Lsm2 Lsm3 Lsm4 Pqbp1 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037628 Rhesus blood group biosynthesis Rhd DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 96%9734735 Defective ADA disrupts (deoxy)adenosine deamination Ada ICOS CO-STIMULATION%REACTOME%R-HSA-9927354.2 ICOS co-stimulation Pik3ca Icosl Pik3r5 Pik3cg Pik3r6 Pik3r1 Pik3cb Pik3r2 Pik3cd ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 96%2033519 Activated point mutants of FGFR2 Fgf16 Fgf18 Fgf2 Fgfr2 Fgf1 Fgf4 Fgf10 Fgf3 Fgf6 Fgf7 Fgf9 Fgf20 Fgf23 Fgf22 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 96%9665251 Resistance of ERBB2 KD mutants to lapatinib Erbb2 Cdc37 Erbin Hsp90aa1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%3769402 Deactivation of the beta-catenin transactivating complex Tle4 Tle2 Tle1 Ctnnbip1 Lef1 Kmt2b Hdac1 Sox9 Akt2 Akt1 Rbbp5 Tle3 Xiap Sox17 Tcf7l1 Tcf7l2 Apc Ywhaz Ctnnb1 Tcf7 Sox3 Btrc Sox2 Sox7 Xpo1 Sox6 Pygo2 Sox4 Pygo1 Ubc Ash2l Sox13 Bcl9l Ctbp1 Bcl9 Cby1 Dpy30 Wdr5 Men1 Chd8 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Nelfa Nelfb Nelfe Ctdp1 Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Polr2b Supt4h1a Polr2g Polr2h Nelfcd Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT Kit TRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72306 tRNA processing Nup133 Elac2 Trnt1 Clp1 Cpsf1 Cstf2 Nup93 Trmu Nup50 Yrdc Nup35 Mto1 Nup54 Osgepl1 Pom121 Nup205 Gtpbp3 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Eprs1 Rpp38 Rpp30 Rpp21 Rpp25 Cpsf4 Rpp40 Ran Rpp14 Trmt112 Nup37 Trp53rkb Nup160 Pop7 Pop5 Nup43 Pop4 Pop1 Fam98b Zbtb8os Ranbp2 Tsen34 AI597479 Rtraf Xpot Rtcb Tsen15 Ddx1 Tsen54 Tsen2 Nup107 Osgep Trmt5 Wdr4 Urm1 Ctu1 Ctu2 Trmt44 Mettl1 Tyw1 Trmt1 Thada Cdkal1 Ftsj1 Trit1 Trmt9b Pus3 Qtrt2 Hsd17b10 Qtrt1 Prorp Trmt61a Trdmt1 Tyw2 Lcmt2 Trmt10c Tyw3 Tyw5 Pus7 Nup85 Dus2 Trmt10a Trmt11 Nsun2 Trmt13 Tprkb Nsun6 Adat1 Alkbh8 Adat2 Thg1l Sec13 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs Alox12 Alox15 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559580 Oxidative Stress Induced Senescence Mapk9 Mapk8 H2bc9 H2bc7 Map3k5 H2bc8 Jun H2bc3 Tnik Cdkn2a Cdkn2b Cdkn2c H2ab2 Txn Map4k4 Kdm6b Ring1 H2bu2 Cbx8 Phc2 Cbx6 Phc1 Cbx4 Tfdp2 Cbx2 Tfdp1 Phc3 Cdk6 Cdk4 Mdm2 Ubc E2f1 Mdm4 E2f2 E2f3 Mapk1 Hist2h2aa1 Mapk3 Bmi1 Ifnb1 Mink1 Mapkapk3 Mapkapk2 Map2k7 Mapk14 Map2k6 Eed Rnf2 Trp53 Mapkapk5 Map2k4 Map2k3 Mapk10 H2bc14 H2ac20 Mapk11 H2bc21 Tnrc6c H2bc26 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago1 H2ac15 H3c7 Ezh2 H2ax Suz12 Hist1h2bp Fos H2aj REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 96%418359 Reduction of cytosolic Ca++ levels Atp2a3 Slc8a1 Slc8a2 Atp2a2 Slc8a3 Atp2b2 Sri Atp2b1 Atp2b4 Atp2b3 Atp2a1 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 96%391906 Leukotriene receptors Ltb4r1 Gpr17 Cysltr2 Ltb4r2 Cysltr1 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 96%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC H2-Q1 Tapbp Canx Erap1 Sec31a B2m Pik3c3 H2-Q10 Sar1b Sec23a H2-M5 H2-M3 Hspa5 Becn1 Pik3r4 Calr Pdia3 Sec24d Sec24c Tap2 Sec24b Sec13 Tap1 Sec24a DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ Abcd4 Lmbrd1 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME%R-HSA-5658034.4 HHAT G278V doesn't palmitoylate Hh-Np Hhat Dhh Ihh Shh PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209952 Peptide hormone biosynthesis Inha Lhb Pomc Pcsk1 Inhba Inhbb Cga Fshb Inhbc Tshb Inhbe DAP12 SIGNALING%REACTOME%R-HSA-2424491.4 DAP12 signaling Tyrobp Lck B2m Vav2 Nras Klrd1 Plcg1 Trem2 Pik3cb Sos1 Grap2 Hras Plcg2 Pik3ca Fyn Lcp2 Rac1 Syk Klrk1 Btk Pik3r1 Pik3r2 Vav3 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190375 FGFR2c ligand binding and activation Fgf16 Fgf23 Fgf18 Fgf2 Fgf1 Fgf4 Fgf6 Fgf9 Fgf20 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 96%194068 Bile acid and bile salt metabolism Amacr Slco1b2 Abcb11 Acox2 Rxra Slc10a2 Slc10a1 Stard5 Slc27a5 Baat Slc51a Slc51b Fabp6 Akr1c18 Acot8 Hsd17b4 Cyp8b1 Osbpl1a Ncoa2 Slc27a2 Ncoa1 Osbp Slco1a4 Cyp39a1 Abcc3 Ch25h Osbpl3 Cyp46a1 Osbpl2 Osbpl7 Osbpl6 Osbpl9 Nr1h4 Akr1c21 Hsd3b7 Alb Cyp27a1 Akr1d1 Cyp7a1 Cyp7b1 Akr1c6 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 96%1912422 Pre-NOTCH Expression and Processing Sel1l St3gal6 Mfng Rfng H2bc9 Pofut1 H2bc7 H2bc8 Poglut1 Jun H2bc3 H2ab2 H2bu2 Mamld1 Elane Tfdp2 Tfdp1 Notch1 Ccnd1 Kat2b E2f1 E2f3 Kat2a Hist2h2aa1 Furin Lfng Trp53 Rab6a H2bc14 H2ac20 St3gal4 Prkci H2bc21 Tnrc6c H2bc26 Tnrc6a Tnrc6b Notch4 Ep300 Atp2a1 Elf3 Mov10 Sirt6 Notch2 H2ac12 H2ac11 Notch3 Ago4 Atp2a3 Ago3 Ago2 Atp2a2 Ago1 B4galt1 H2ac15 H3c7 H2ax Maml1 Maml2 Hist1h2bp Rbpj H2aj Crebbp INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade Pde6g Prkca Pde6a Pde6b Gucy2e Grk1 Sag Rho Gnat1 Cnga1 Fnta Gucy2f Fntb Camkmt Gngt1 Metap1 Metap2 Rcvrn Nmt1 Rgs9bp Ppef1 Gnb1 Guca1b Nmt2 Guca1a Prkcq EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle Psip1 Hmga1 Xrcc4 Ppia Cd4 Xrcc6 Ccr5 Xrcc5 Lig1 Kpna1 Fen1 Cxcr4 Banf1 Lig4 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME%R-HSA-162589.3 Reverse Transcription of HIV RNA Ppia DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 96%3656225 Defective CHST6 causes MCDC1 Prelp Chst5 Omd Lum Ogn Fmod Kera CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Actn2 Nefl Grin1 Dlg1 Grin2d Dlg3 Nras Dlg4 Rps6ka6 Camk2g Hras Camk2d Grin2b Camk2b Camk2a Mapk1 Mapk3 Rps6ka3 Rasgrf1 Rps6ka1 Rasgrf2 Pdpk1 Rps6ka2 Dlg2 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%1592230 Mitochondrial biogenesis Sirt4 Esrra Sod2 Acss2 Hcfc1 Glud1 Gabpa Pprc1 Sirt5 Nrf1 Prkag3 Ppargc1b Prkag1 Prkag2 Polg2 Mapk12 Twnk Chchd6 Samm50 Polrmt Chchd3 Mapk14 ATP6 Sirt3 Immt Atp5f1d Ssbp1 Atp5pb Atp5f1c Atp5pf Apool Mtx1 Mtx2 Tmem11 Mterf1b Ppara Atp5mc3 Apoo Atp5mf Alas1 Hspa9 Atp5me Dmac2l Rxra Atp5f1b Mapk11 Atp5f1a Prkaa2 Dnajc11 Atp5mk Micos10 Micos13 Tfb2m Tfam Ncor1 Atf2 Helz2 Carm1 Prkab2 Camk4 Prkab1 Tbl1x Mef2d Crtc3 Hdac3 Crtc2 Ncoa2 Ncoa1 Tbl1xr1 Tfb1m Smarcd3 Crtc1 Ncoa6 Med1 Nr1d1 Ppargc1a Crebbp Mef2c Chd9 Idh2 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 96%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) Slc24a5 PI3K CASCADE%REACTOME DATABASE ID RELEASE 96%109704 PI3K Cascade Fgf16 Frs2 Fgf15 Them4 Irs1 Fgf18 Irs2 Fgf2 Pik3c3 Fgf1 Fgf4 Gab1 Fgf10 Fgf3 Fgf6 Fgf7 Fgf9 Trib3 Fgf20 Ptpn11 Gab2 Fgf23 Fgfr4 Fgf22 Akt2 Pde3b Tlr9 Pik3r4 Flt3l Pik3cb Pik3ca Flt3 Pdpk1 Pik3r1 Pik3r2 Klb LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 96%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions Itgb1 Parva Pxn Ilk VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%192814 vRNA Synthesis Parp1 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME%R-HSA-5579032.4 Defective TBXAS1 causes GHDD Tbxas1 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling Trpc3 Unc5a Pitpna Ezr Wasl Trio Hjv Plcg1 Myo10 Ablim1 Slit1 Ablim2 Slit3 Ablim3 Robo1 Ptpn11 Neo1 Nck1 Slit2 Dcc Ntn1 Agap2 Dscaml1 Src Ntn4 Unc5d Unc5c Rgmb Rgma Rac1 Siah1a Ptk2 Trpc6 Trpc5 Trpc7 Siah2 Dock1 Trpc1 Prkcq Unc5b Trpc4 Dscam TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME%R-HSA-1362300.3 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 Tfdp2 Tfdp1 E2f4 E2f5 Mybl2 Hdac1 E2f1 Rbl2 Ccna2 Lin54 Rbbp4 Lin9 Rbl1 Lin37 Cdk1 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-HSA-2470946.2 Cohesin Loading onto Chromatin Pds5b Pds5a Smc1a Mau2 Rad21 Smc3 Stag2 Nipbl Stag1 Wapl SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions Slc26a2 Slc26a1 Slc20a2 Slc17a1 Slc5a8 Slc26a6 Slc26a9 Slc12a1 Slc26a7 Slc12a4 Slc12a5 Slc12a2 Slc12a3 Slc12a6 Slc12a7 Slc34a1 Slc34a3 Ahcyl2 Slc34a2 Slc26a11 Slc13a4 Slc13a1 Slc4a10 Slc4a7 Slc4a2 Slc4a3 Slc4a5 Slc4a8 Slc4a9 Slc4a1 Slc4a4 Slc26a4 Slc26a3 Slc5a5 Slc20a1 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events Anxa1 Ppp3r1 Ppp3ca Ppp3cb C3ar1 App Prkx Rgs9 Rgs6 Rgs7 Ppp1ca Cdk5 Prkacb Npy Adcy3 Adcy4 Gna11 Adcy1 Gna15 Adcy2 Gna14 Adcy7 Adcy8 Adcy5 Adcy6 Gnaz Adcy9 Gnaq Gnai2 Gnai1 Cxcr4 Gnai3 Prkar1b Gnat3 Prkar2b Cxcl12 Rgs11 Rgsl1 Gng10 Fpr2 Lpar5 Gpr17 Gng3 Nms Gng2 Nmu Nmur2 Gng4 Plcb4 Nmur1 Gng7 Gng8 Prkar2a Gngt1 Gngt2 Camk2g Camk2d Agt Ahcyl1 Camk2b Camk2a Gnb2 Gnb1 Gnb4 Rgs4 Gnb3 Rgs5 Gnb5 Gng11 Rgs3 Gng12 Gng13 Rgs1 Prkaca Casr Itpr3 Camkk1 Itpr2 Camkk2 Bdkrb2 Itpr1 Bdkrb1 Kng2 Prkcg Pmch Gnal Lpar3 Lpar2 Lpar1 Rgs21 Gabbr1 Rgs17 Rgs18 Gabbr2 Rgs19 Rgs13 Rgs16 Adra2a Adra2c Adra2b Ppp2cb Ppp2ca Rho Gnat1 Ppp2r1b Ppp2r1a Pla2g4a Saa3 Grk2 Pde1b Pde1c Prkcd Sst Pde1a C5ar1 C3 Ppp2r5d C5 Sstr3 Oprm1 Plcb3 Plcb2 Plcb1 Prkca Gnat2 Prkar1a Mchr1 Camk4 Pdyn Galr2 Galr3 Rxfp3 Galr1 Rln3 Fpr1 Tas1r2 Tas1r1 Pomc Tas1r3 Rxfp4 Pnoc Tas2r131 Insl5 Tas2r135 Tas2r137 Tas2r136 Gpr18 Tas2r140 Tas2r4 Fpr-s1 Ccr5 Tas2r7 Ptger3 Mtnr1a Mtnr1b Agtr2 Gpr37 Gpr31 Oprk1 Rgr Ptgdr2 Cx3cl1 Ccl28 Ccl25 P2ry13 P2ry12 Ccl20 Gpr55 P2ry14 Oxgr1 Sucnr1 Psap P2ry4 Ccl5 Ccl4 Ccl2 Ccl1 Rrh Apln Tas2r39 Oprd1 Tas2r38 Sstr5 Sstr4 Sstr2 Sstr1 Gpr183 Src Ppbp Ccr10 Tas2r16 Cx3cr1 Tas2r13 Ppy Ccr1 Npbwr1 Ccr9 Pf4 Ccr8 Ccr7 Ccr6 Ccr4 Mapk1 Ccr3 Ccr2 Gal Rgs8 Pcp2 Penk Gpsm3 Npb Gpsm2 Opn1mw Gpsm1 Npw Chrm2 Ppp1r1b Tas2r40 Tas2r41 Hrh4 Pde4a Hcar1 Chrm4 Rgs20 Hcar2 Rgs22 Cxcr1 Rgs14 Cxcr2 Pde4c Npy1r Pde4d Cxcr3 Rgs10 Rgs12 Cxcr5 Cxcr6 Oprl1 Drd3 Cxcl11 Drd4 Hebp1 Cxcl10 Aplnr Opn1sw Opn3 Htr1d Gper1 Htr1f Opn5 Pyy Adora1 Adora3 Htr1b Cxcl16 Cxcl13 Htr5a Tas2r119 Npy5r Grm3 Grm2 Grm4 Grm7 Grm8 Npy4r Tas2r120 Cxcl9 S1pr3 Cxcl1 S1pr2 S1pr5 Cxcl2 S1pr4 Cxcl3 Cxcl5 Tas2r107 Gpr37l1 Npy2r Ackr3 Cnr1 Ppp3cc Cnr2 Cort SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription Vhl Rb1 Zcrb1 Ddx5 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 96%3296469 Defects in cobalamin (B12) metabolism Mmab Mmadhc Mmachc Cd320 Abcd4 Cblif Mtrr Amn Mtr Mmaa Lmbrd1 Mmut Tcn2 Cubn ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%8937144 Aryl hydrocarbon receptor signalling Ahrr Ahr Aip Arnt Hsp90ab1 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%376172 DSCAM interactions Dcc Ntn1 Dscaml1 Dscam ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME%R-HSA-9956520.1 ASS1 variants cause citrullinemia Nmral1 Ass1 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions Slco1c1 Slco1b2 Avp Slco4c1 Slco4a1 Slco2b1 Slco2a1 Slc16a2 Slco1a4 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 96%445144 Signal transduction by L1 Pak1 Map2k2 Vav2 Nrp1 Itga9 Map2k1 Itga5 Itgb3 Csnk2a2 L1cam Egfr Ncam1 Itgav Itga2b Itgb1 Rac1 Mapk1 Mapk3 Csnk2b FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 96%9769733 Fibrin formation F2 Fgb Fga Fgg Itgb3 Serpina5 Serpine2 F13b Itga2b F13a1 Proc Serpinc1 Serpind1 HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis Epcam Ppia Rasgrp1 Rcor1 App Plcg2 Hmg20b Cdk5 Prkacb Irf2 Tnfrsf10b Mfn1 Mfn2 Dock7 Syk Fgr Alb Gnai2 Gnai1 Gnai3 Akap1 Prkar1b A2m Gnat3 Prkar2b Plaur Apool P2rx6 P2rx5 P2rx3 P2rx7 P2rx2 P2rx4 P2rx1 Gng10 Cd36 Kcnmb1 Kcnma1 Gng3 Gng2 Hspg2 Gng4 Inpp5d Sdc4 Sdc3 Gng7 Sdc2 Gng8 Atp2a1 Atp2a3 Gngt1 Atp2a2 Gngt2 Itpk1 Sri Dock8 Sdc1 Mafg Nos1 Slc8a1 Gnb2 Slc8a2 Atp1b1 Gnb1 Slc8a3 Gnb4 Atp1b3 Gnb3 Akap10 Atp2b2 Gnb5 Ak3 Atp1b2 Gng11 Gata5 Atp2b1 Atp2b4 Hbb-y Gng12 Maff Atp2b3 Gng13 Cd9 Ehd1 Slc16a3 Orai1 Ehd2 Orai2 Ehd3 Slc16a8 Prkaca Mical1 Stim1 Hbb-bh1 Jmjd1c Jchain Cables2 Kif18b Itpr3 Carmil1 Itpr2 Sh2b1 Kif26b Kifc2 Itpr1 Kif12 Kif21a Kif1c Kif21b Kif13b Prkcg Kif1a Aldoa Kif1b Kif6 Kif9 Gpc1 Kif27 Gpc3 Kif16b Gpc2 Prtn3 Kif20b Kif19a Gpc5 Gpc4 Pick1 Gpc6 Cd44 Rbsn Tspan7 Mertk Cdk2 Hspa5 Pros1 Gas6 Agrn Ifnb1 Itgax Itgam Ppp2cb Ppp2ca Itgb2 Cd47 Jam3 Jam2 Plcg1 Kif2a Kif2b Kif2c Dock3 Egf Ppp2r1b Ppp2r1a Gata6 Kif18a Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Ano6 Ano5 Plat Serpinb8 Serpina10 Plau S100a10 Serpinb6a Spn Ppp2r5e Ppil2 Mag Cenpe Serpind1 Slc7a11 Slc7a10 F3 Slc3a2 Slc7a6 Slc7a7 Slc7a5 Kif3a Kif3b Kif3c Slc7a8 Slc7a9 Pafah2 Prkca Igf2 Igf1 Prkg2 Nos3 Akt1 Cd74 Prkar1a Kif26a Kif11 Kif15 Lyn Yes1 Actn2 Kif22 Lamp2 Kif23 Cxadr Selplg Kif20a Jaml Klc1 Cd84 Klc4 H3c7 Sele Glg1 Klc3 Klc2 Sell Esam Vpreb1b Sirpa Vpreb3 Cd99l2 Olr1 Gypc Rac1 Fcamr Myb Cd244 Cd2 Cd48 Trem1 Vav1 Pik3r5 Pik3r6 Kifap3 Pik3r1 Pik3r2 Gata3 Gata4 Gata1 Gata2 P2ry12 Nfe2 Psap Rac2 Sh2b2 Sh2b3 Serpinc1 Proc Ppbp Rab5a Pik3cg Pik3cb Pf4 Cyb5r1 Pik3ca Pde10a Pde11a Kif5b Pdpk1 Kcnmb2 Pde2a Lck Irf1 Kcnmb4 Ptpn6 Itga5 F11r Rhoa Prkcz Ptpn11 Fyn Csk Itga4 Abl1 Brpf3 Rhog Sin3a Ptgir Itgal Dock5 Itgb1 Ptpn1 Dock4 Gucy1b1 Gp9 Gp1bb Flna Gp5 Dock1 Stx4 Dock2 Gucy1a1 Capzb Gucy1a2 Capza1 Capza2 Tgfb2 Timp1 Mgll Kdm1a Adamts13 Vegfa Tgfb3 Tuba4a Gna11 Gna15 Gna14 L1cam Itgav Ptk2 Anxa2 Gnaq Cbx5 Pfn1 Kif4 Trp53 Itga10 Zfpm2 Cap1 Itga2b F12 Klkb1 Prkar2a F2 Mmp1a F2rl2 F2rl3 F2r Tgfb1 Kng2 P2ry1 Lcp2 Serpine1 Lat Dock11 Pde9a Irag1 Adra2a Adra2c Adra2b Gp6 Mpig6b Fcer1g Pdpn Proz F7 Angpt1 F9 Tek Procr Hdac2 Serpina5 Serpine2 Smpd1 F13b Cd109 Cd177 Nhlrc2 Phactr2 Thbd Stxbp2 Stxbp3 Tex264 Fermt3 Vti1b Itga6 Lefty2 Chid1 Manf Dock6 A1bg F10 Itga3 Pdgfb Itga1 Islr Itga2 Sparc Pcyox1l Grb14 Apoh Angpt2 Hrg Pla2g4a Angpt4 Gtpbp2 Pde1b Ecm1 Ola1 Prkcd Orm3 Pde1a Ctsw Serping1 Calu Rab27b Selenop Lhfpl2 Actn4 Sytl4 Clu Ahsg Spp2 Vegfd Vegfc Vegfb Serpina3n Cd63 Timp3 Rapgef4 Rapgef3 Tor4a Cfd Mpl Fam3c Trpc6 Serpinf2 Zfpm1 Cfl1 Trpc7 Thbs1 F13a1 Tmx3 Anxa5 Trpc3 Scg3 Qsox1 Selp Lgals3bp Cyrib Sccpdh Srgn Wdr1 Maged2 Pecam1 Endod1 Thpo Aplp2 Gp1ba Clec3b Mmrn1 Habp4 Fn1 Plg Bcar1 Ttn Rarres2 Cdc37l1 Plek Tagln2 Itih4 Itih3 Aamp Prkcb Grb7 F5 F8 Serpina1d Prkcq Rasgrp2 Hdac1 Daglb Dgka Dgkb Abhd6 Dgke Abhd12 Dgkg Dgkh Dgki Dgkk Dgkq Prkch Dgkz Dagla Prkce Ywhaz Nos2 Rhob Rad51c Rad51b Cav1 Bsg Pcdh7 Apbb1ip Arrb2 Vav3 Dok2 Arrb1 Jak2 Slc16a1 Fgb Fga Vps45 Rap1b Vwf Vav2 Abcc4 Fgg Itgb3 Raf1 Tln1 Vcl Pde5a Gna12 Tbxa2r Gna13 Actn1 Src Hgf Tf Shc1 Cables1 Mapk1 Mapk3 Wee1 Rap1a Mapk14 Nras Sos1 Crk Hras Dock10 Racgap1 Clec1b Mafk Hbbt1 Serpinb2 Mif Apoa1 Apob DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME%R-HSA-4085011.4 Defective GNE causes sialuria, NK and IBM2 Gne CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress Sp1 Tlr4 Dnaja2 Prdx2 Jun Prdx1 Sod2 Ywhae Foxo3 Lmnb1 Nlrp3 Notch1 Rbx1 Creb3l3 Yme1l1 Il1a Phb2 Alb Stoml2 P4hb Idh1 Hspa9 Stap2 Aqp8 Ero1a Prdx3 Camk2g Mul1 Abcc3 Camk2d Atf4 Sesn1 Camk2b Dpp3 Mafg Camk2a Gclc Gclm Prdx6 H13 Me1 Abcf2 Txnrd2 Gpx3 Gpx6 Txn2 Gpx5 Gpx8 Blvrb Gpx7 Blvra Chd6 Gsta3 Ccl12 Nudt2 Srxn1 Nqo1 Tkt Ubxn7 Mapk9 Sod3 Mapk7 Ccs Atox1 Mapk8 Ets1 Map3k5 Cul3 Ets2 Tinf2 H1f2 H1f3 Tnik Cdkn2a Cdkn2b Cdkn2c Hira Ehmt2 Erf Ehmt1 H3c8 Txn Map4k4 Kdm6b Cabin1 Il6 Ring1 Cbx8 Phc2 Ccne1 Cbx6 Phc1 Ccne2 Acd Fzr1 Cbx4 Tfdp2 Cbx2 H1-1 Nrf1 Tfdp1 H1-0 Skp2 Lonp1 Asf1a Dele1 Rb1 Phc3 Htra2 Terf2ip Dnaja4 H1-5 Extl2 Dnaja1 H1-4 Cdk6 Cdk4 Mdm2 Cdk2 Hmga2 Mdm4 E2f1 Extl3 E2f2 Ccna1 E2f3 Hspa5 Ccna2 Terf2 Cdkn1a Terf1 Ep400 Cdkn1b Bmi1 Ifnb1 Igfbp7 Rps6ka3 Abcc1 Mink1 Pgd Rps6ka2 Pot1 Nup37 Map2k7 Nup160 Cebpb Map2k6 Rnf2 Ubn1 Mapkapk5 Map2k4 Nup43 Map2k3 Mapk10 Ranbp2 Dync1li2 Prkci Egf Dync1li1 Bcl2 Pdgfa Nup107 Bcl2l1 Areg Dynll1 Dynll2 Rps27 Atf6 Dync1h1 Hspa1l Nup85 Egln2 Egln3 Hif1an Wtip Dync1i2 Limd1 Dync1i1 Taldo1 Ppp2r5b Lmna Atp7a Sec13 Hspa2 Actr1a Dctn2 Dctn3 Nup133 Eif2s3x Eif2s2 Eif2s1 Fbxl17 Slc7a11 Hif3a Gsk3a H2ac20 Syvn1 Trib3 Prkaa2 Myc Akt3 Akt2 Akt1 Atf3 Eif2ak3 Hif1a Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago1 H2ac15 H3c7 Ezh2 H2ax Csnk2a2 Suz12 Exosc9 Exosc8 Exosc5 Hist1h2bp Dis3 Fos Exosc4 Exosc7 Ddit3 Exosc6 H2aj Txnip Parn Exosc1 Exosc3 Exosc2 Higd1c Cited2 H2bc9 H2bc7 H2bc8 H2bc3 mt-Co2 mt-Co3 Stat3 H2ab2 H2bu2 Vcp Hist2h2aa1 Epas1 Csnk2b Eed Gsk3b Mlst8 Sesn2 Coxfa4 H2bc14 Mtor H2bc21 Tnrc6c H2bc26 Rbbp4 Rbbp7 Tnrc6a Tnrc6b Ajuba Sin3a Gpx2 Cox7a1 Cox7a2 Dcp2 Eloc Cox7a2l Capzb Capza1 Capza2 Acadvl Nox4 Fabp1 Fkbp5 Fkbp4 Vegfa Eif2ak4 Fnip1 Samtor Szt2 Itfg2 Gcn1 Nprl3 Nprl2 Wdr59 Ube2d3 Mios Depdc5 Kptn Impact Castor1 Kics2 Wdr24 Flcn Sh3bp4 Dnajc7 Hsph1 Dnajc2 Cryab Hikeshi Trp53 Hspa14 Hspa13 Rps19bp1 Hsbp1 Cul2 St13 Hspa12b Hspa12a Bag5 Nup93 Bag4 Hsf1 Nup50 Bag3 Nup35 Bag1 Nup54 Hspb8 Pom121 Nup205 Dnajb6 Nup188 Dnajb1 Tpr Hspa4l Rae1 Hspa4 Ndc1 Ccar2 Nup42 Nup62 Nup88 Aaas Chac1 Nup214 Nup210 Nup155 Nup153 Hmga1 Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Hsp90aa1 Rpl32 Rps9 Rps7 Rps5 Gfpt1 Rpl24 Rpl26 Rpl22 Rpl23 Rps25 Rps26 Rps21 Eif2ak1 Atf5 Rpl39l Rps15a Ncor2 Dnajc3 Calr Rps27l Rplp2 Rpl22l1 Sqstm1 Rplp1 Rpl13a Rpl18a Hspa1a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Rps3 Cox6a1 Rps4x Cox6a2 Hspa8 Amer1 Cox6b1 Cox6b2 Hdac6 Oma1 Arnt G6pdx Prkcd Hsp90b1 Keap1 Arfgap1 Cox8a Grb10 Cox7b Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Psmb5 Preb Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Cox5a Psmb2 Rela Sec31a Btrc Psma7 Psmc6 Psmc5 Stip1 Psmc2 Psmc1 Psmc4 Psmc3 Gosr2 Ubc Psmd7 Psmd6 Map1lc3b Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Sirt3 Nr3c2 Nr3c1 Rora Ppara Esr1 Ar Add1 Rxra Mydgf mt-Co1 Extl1 Pgr Srprb Txnrd1 Srpra Asns Yif1a Cox4i1 Edem1 Actr10 Cul7 Kat5 Cox4i2 Dctn5 Herpud1 Hspd1 Dctn6 Dctn1 Ddx11 Dctn4 Rps6ka1 Nbn Cxxc1 Capza3 Pdia6 Pdia5 Creb3 Dcstamp Ern1 Klhdc3 Serp1 Cebpg Cat Creb3l4 Creb3l1 Id1 Creb3l2 Kdelr3 Tspyl2 Fkbp14 Atf6b Ssr1 Hyou1 Hdgf Wipi1 Wfs1 Tatdn2 Igfbp1 Crebrf Dnajb9 Zbtb17 Tpp1 Dnajb11 Mre11a Palb2 Bag2 Rad50 Rpa1 Rpa2 Trim21 Vhl Brca1 Rpa3 Atm Tln1 Anapc5 Anapc4 Anapc1 Anapc2 Anapc11 Ube2c Anapc10 Anapc7 Cdc27 Ube2d1 Cdc16 Anapc16 Ube2e1 Hsp90ab1 Cdc23 Anapc15 Atp6v0b Atp6v1g3 Hmox2 Atp6v0e2 Atp6v1c2 Atp6v1c1 Ptk6 Shc1 Mapk1 Mapk3 Abcg2 Ncf1 Ncf2 Ncf4 Rptor Mapkapk3 Atp6v1e2 Atp6v1e1 Mapkapk2 Mapk14 Tcirg1 Slc38a9 Atp6v1a Atp6v1b2 Lamtor5 Akt1s1 Atp6v0d2 Lamtor4 Atp6v0d1 Rraga Atp6v1b1 Rragb Atp6v0e1 Atp6v1g2 Lamtor1 Atp6v1g1 Rragc Lamtor2 Rragd Atp6v1f Atp6v1d Mapk11 Atp6v1h Ncor1 Atf2 Slc46a1 Helz2 Cyba Carm1 Nrip1 Ep300 Tbl1x Cybb Hmox1 Mef2d Epo Clock Car9 Clec1b Bmal1 Crtc3 Hdac3 Crtc2 Rai1 Ncoa2 Ncoa1 Xpo1 Ufd1 Tbl1xr1 Smarcd3 Nploc4 Crtc1 Ncoa6 Hba-a1 Mafk Hbbt1 Npas2 Med1 Bach1 Nfyb Nr1d1 Pgrmc2 Nfya Nfyc Ppargc1a Nfe2l2 Ly96 Mbtps1 Crebbp Mef2c Mbtps2 Apoa1 Chd9 Sirt1 Apob DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 96%3359475 Defective MMAA causes MMA, cblA type Mmaa Mmut EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646303.4 Evasion of Oncogene Induced Senescence Due to p14ARF Defects Cdkn2a DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection Tlr4 Clec5a Dnajc8 Ddx3x Sun2 Xrn1 Rbm22 Mmp9 Rbm17 Ddx46 Ddx42 Dnaja2 Eif4g2 Eif4g3 Cd2bp2 Ddx23 Eif4e3 Ap2m1 Stat2 Ddx5 Sympk Cstf1 Papola Clp1 Nudt21 Ap2a2 Cpsf1 Cstf2 Ap2a1 Cpsf2 Cstf3 Cpsf3 Cstf2t Wdr33 Hdlbp Ripk1 Ap2b1 Pdcd6ip Ap2s1 P4hb Ybx1 Pabpc1 Hspg2 Sdc4 Kpna1 Sdc3 Sdc2 F2 Sdc1 Camk2g Dpm1 Dpm2 Camk2d Dpm3 Camk2b Camk2a Rpsa Kpnb1 Hsp90aa1 Kpna4 Kpna7 Kpna3 Cpsf4 Havcr1 Cdc73 Rtf1 Gpc1 Dnajc3 Gpc3 Gpc2 Leo1 Skic8 Calr Gpc5 Gpc4 Gpc6 Hspa1a Rpl18 Ctr9 Paf1 Canx Pabpn1 Tyro3 Mapre3 Mrc1 Emc4 Timd4 Cldn1 Hspa8 Mertk Rnasek Cd300a Axl Hspa5 Pros1 Daxx Ly6e Gas6 Agrn Fasn Rnps1 Pik3c3 Srsf1 Srsf9 Cdc40 Eif4a2 Eif4a1 Srsf7 Srsf6 Pik3r4 Srsf3 Srsf2 Srsf11 Srrm1 Nrbp1 Alyref Dhx38 U2af1l4 Elavl1 Eif4a3 Snrpb H2ac21 H2ac25 Snrpd2 Hist1h2af Snrpd1 Clu H2ac1 Snrpd3 C4a Atg7 C1qa C1s2 Taok1 Mbl2 Cgas Sting1 Dhx9 Vtn Cd14 Ikbke Exoc1 Hnrnpu Tjp1 H2bc18 Ubc Polr2c Polr2d Polr2a Polr2b Nfkbib Polr2g Map1lc3b Polr2h Becn1 Polr2e Polr2f Polr2k Nfkbia Polr2i Polr2j Ubr4 Gtf2f2 Uba5 Gtf2f1 Uba6 Uba7 H2ac20 Prkg2 Acot2 Ube2i Uba1 Uba3 Rpn2 Rpn1 Lyn H2ac12 H2ac11 H2ac15 Tsg101 H3c7 Phf5a Hyou1 Crnkl1 Nmt1 Btf3 Hist1h2bp Dnajb11 Xab2 Aup1 Ipo7 Hnrnpa2b1 Pik3r1 Prpf19 Bag2 P4ha1 P4ha2 P4ha3 Puf60 Hnrnpul1 Gbf1 Bcas2 Magt1 Gpkow Smndc1 Aqr Pcbp2 Pcbp1 H2bc9 Grpel1 H2bc7 Hnrnpr H2bc8 Clint1 H2bc3 Sugp1 Hnrnpd Hnrnpf Hnrnpk Ccar1 Hnrnpl Tmem258 Hnrnpm Rictor Rbmx Hnrnph2 Hnrnph1 Nek2 Cwc22 Sec11c Ifih1 Hsp90ab1 Sec11a H2bu2 Cwc27 Cpsf7 Hnrnpc Cwc25 Cwc15 Trim25 Stt3a Mavs Stt3b Rbm5 Tal1 Ctnnb1 Vcp Ostc Txnl4a Vim Fip1l1 Rrbp1 Snrnp200 U2surp Snrpb2 Tusc3 Snrpa1 Cog1 Ptbp1 Hist2h2aa1 Furin Kdelr1 Prr5 Dad1 Rptor Eif4g1 Atl2 Ddost Sf3a1 Sf3a2 Sf3a3 Dnajc10 Sf3b1 Sf3b2 Sf3b3 Mlst8 Sf3b4 Sf3b5 Sf3b6 H2bc14 Ctnnbl1 Srrt Mtor Snrnp40 Eftud2 Eif4e Snrpn H2bc21 Cd209a H2bc26 Cherp Fus Isy1 Cdc5l Plrg1 Hnrnpa3 Mapkap1 Ppil6 Ppil4 Ppil3 Hnrnpa1 Hnrnpa0 Ppil1 Prcc Rbm10 Elavl2 Xpo1 Ufd1 Dhx16 Dhx15 Nploc4 Retreg1 Scap Srrm2 Spcs3 Ncbp2 Spcs1 Ncbp1 Spcs2 Pex19 Prpf6 Pdia3 Ly96 Ppie Apoa1 Prpf8 Wbp11 Rtn3 Pqbp1 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%389661 Glyoxylate metabolism and glycine degradation Dao Amt Gldc Got2 Dld Gnmt Ogdh Dlst Gcsh Pxmp2 Agxt2 Hoga1 Ddo Aldh4a1 Hao1 Grhpr Agxt Prodh2 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 96%9834899 Specification of the neural plate border Ctnnb1 Fgf4 Sox2 Bmp4 Tfap2c Pou5f1 Gbx2 Tfap2a Tfap2b Zic1 Myb Dlx5 Pax3 Pax7 Wnt3a Tcf7l1 Msx1 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447043 Neurofascin interactions Dcx Nrcam Sdcbp Ank1 Cntn1 Cntnap1 Nfasc DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 96%5579015 Defective CYP26B1 causes RHFCA Cyp26b1 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME%R-HSA-9735763.2 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine Pnp MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%1632852 Macroautophagy Mtmr3 Chmp2a Plin3 Ift88 Prkn Optn Chmp3 Chmp7 Chmp6 Ube2l3 Pcnt Mfn1 Gabarapl2 Chmp4c Mfn2 Chmp4b Ulk1 Vdac2 Ube2d3 Atg3 Gabarap Ubc Vdac3 Rb1cc1 Atg10 Atg13 Gabarapl1 Atg9b Map1lc3b Vdac1 Becn1 Atg101 Uvrag Ambra1 Wdr45b Wdr45 Atg16l2 Atg16l1 Wipi2 Atg4b Ube2n Atg4c Atg4a Atg4d Ube2v1 Hsf1 Prkaa1 Prkaa2 Tomm22 Cftr Tomm40 Cetn1 Plin2 Park7 Csnk2a2 Wipi1 Tomm6 Tomm7 Hsp90aa1 Usp30 Pex5 Map1lc3a Fundc1 Atg5 Atg12 Atg9a Atm Nbr1 Sqstm1 Vcp Prkag3 Prkag1 Prkag2 Hspa8 Tomm70 Rptor Epas1 Csnk2b Slc38a9 Lamtor5 Lamtor4 Rraga Pik3c3 Mlst8 Rragb Lamtor1 Rragc Lamtor2 Rragd Tsc2 Dync1li2 Mtor Tsc1 Dync1li1 Tbk1 Hdac6 Pik3r4 Arl13b Dynll1 Dynll2 Prkab2 Prkab1 Dync1h1 Mterf3 Pink1 Dync1i2 Dync1i1 Atg7 Mtmr14 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 96%8849932 Synaptic adhesion-like molecules Lrfn3 Lrfn4 Flot2 Flot1 Grin1 Dlg1 Grin2d Dlg3 Grin2c Dlg4 Gria4 Gria3 Ptprs Gria1 Grin2b Ptprf Grin2a Rtn3 Lrfn2 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-9759785.2 Diseases of propionyl-CoA catabolism Mmaa Mmut RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress Prkaca Pecam1 Pkn2 Itgb3 Flt4 Ikbkb Tln1 Vcl Mmp14 Capn2 Ikbkg Stat1 Rictor Ikbke Nfkb1 Capns1 Capns2 Prkacb Rela P2ry2 Ctnnb1 Adcy3 Adcy4 Gna11 Adcy1 Adcy2 Adcy7 Pik3cb Adm Adcy8 Pik3cd Adcy5 Adcy6 Kdr Pik3ca Adcy9 Itgav Ppp2r2a Ptk2 Anxa2 Gnaq Prr5 Nfkbia Pdpk1 Calcrl Prkar1b Chuk Cdh5 Ppp2ca Prkar2b Mlst8 Gng10 Itga5 Mtor Fyn Nos3 Gng3 Akt1 Gng2 Prkar1a Gng4 Abl1 Gng7 Mapkap1 Gng8 Ppp2r1b Ppp2r1a Prkar2a Gngt1 Gngt2 Panx1 Itgb1 Ptpn1 Ramp2 Gnb2 Gnb1 Gnb4 Trpv4 Gnb3 Gnb5 Gng11 Pik3r2 Gng12 Yap1 Gng13 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology Prkaca Sin3a Hdac3 Kmt2d Gps2 Tbl1xr1 Hdac1 Ash2l Ncor2 Rbbp5 Ncor1 Dpy30 Camk4 Wdr5 Tbl1x JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-HSA-450321.4 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ube2v1 Map2k4 Tab3 Nod2 Tab2 Nod1 Tab1 Mapk10 Mapk9 Mapk8 Irak2 Ripk2 Ikbkg Map3k7 Irak1 Traf6 Map2k7 Ube2n METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 96%196757 Metabolism of folate and pterines Aldh1l2 Shmt2 Folr2 Slc19a1 Mthfsl Mthfr Mthfd1 Mthfd2 Slc25a32 Mthfd1l Dhfr Mthfd2l Slc46a1 Aldh1l1 Shmt1 DEATH RECEPTOR SIGNALING%REACTOME%R-HSA-73887.7 Death Receptor Signaling Itgb3bp Prex1 Trio Mcf2 Rbck1 Ikbkb Mag Birc3 Birc2 Lingo1 Omg Rtn4 Ikbkg Tradd Map3k7 Traf2 Bcl2l11 Ywhae Ikbke Xiap Bex3 Fasl Optn Nfkb1 Tnfsf10 Tnfrsf10b Fadd Ube2l3 Rela Casp3 Casp8 Ulk1 Ripk1 Ube2d3 Stub1 Ubc Fas Irak1 Nfkbia Traf6 Chuk Tab3 Tab2 Tab1 Bag4 Hdac1 Sos2 Bad Arhgef17 Tax1bp1 Arhgef11 Clip3 Arhgef10 Smpd2 Smpd3 Nsmaf Sppl2b Akap13 Rac1 Otulin Sppl2a Casp2 Vav1 Arhgef3 Arhgef2 Arhgef1 Maged1 Ect2 Vav3 Net1 Arhgef10l Vav2 Mapk8 Tiam2 Arhgef15 Arhgef19 Mib2 Ngef Arhgef9 Arhgef7 Arhgef6 Ngfr Arhgef4 Sqstm1 Gna13 Rasgrf2 Fgd2 Ube2d1 Fgd1 Fgd4 Arhgef37 Fgd3 Arhgef39 Arhgef38 Arhgef40 Plekhg5 Plekhg2 Rack1 Aatf Mapkapk2 Prdm4 Usp2 Ngf Tiam1 Sharpin Usp21 Traf1 Tnf Spata2 Rnf31 Usp4 Tnfrsf1a Sos1 Cyld Otud7b Abr Rhoa Hdac2 Tnfaip3 Prkci Arhgef18 Ripk2 Tbk1 Myd88 Mcf2l Arhgdia Adam17 Arhgef16 Hdac3 Psen1 Arhgef26 Itsn1 Psen2 Ncstn Aph1b Kalrn Cflar DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX F8 F9 F10 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450385.3 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Dcp1a Xrn1 Zfp36l1 Exosc9 Exosc8 Exosc5 Dis3 Akt1 Exosc4 Exosc7 Exosc6 Ywhab Exosc1 Exosc3 Exosc2 Dcp2 Mapkapk2 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 96%9616333 Defective Base Excision Repair Associated with NTHL1 Nthl1 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%8948747 Regulation of PTEN localization Usp7 Pten Nedd4 Xiap Pml Ubc FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Nelfa Nelfb Nelfe Ctdp1 Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Polr2b Supt4h1a Polr2g Polr2h Nelfcd Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) Rdh10 Hsd17b6 Lrat Ttr Cyp4v3 Rdh16f2 Hsd17b1 Rdh5 Rbp4 Dhrs9 Rbp3 Rpe65 Rbp1 Myo7a Rdh12 Stra6 Rho Abca4 Rdh8 Rlbp1 Sdr9c7 Rdh11 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 96%9761174 Formation of intermediate mesoderm Fgf2 Osr1 Pax2 Bmp4 Foxc2 Lhx1 Foxc1 Pax8 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 96%380270 Recruitment of mitotic centrosome proteins and complexes Prkaca Ccp110 Alms1 Cetn2 Tubgcp2 Nedd1 Tubg2 Actr1a Nme7 Tuba1a Tubgcp5 Tubgcp4 Tubgcp3 Cep43 Mzt1 Dctn2 Mzt2 Cep41 Dctn3 Plk1 Ninl Ywhae Cdk1 Nek2 Pcnt Tuba4a Cep250 Sdccag8 Cep78 Cep76 Cep72 Cep70 Tubb5 Plk4 Cpap Clasp1 Ywhag Pafah1b1 Cep135 Cep131 Prkar2b Csnk1e Tubb4b Haus7 Tubb4a Haus8 Cdk5rap2 Cep57 Pcm1 Mapre1 Dynll1 Ssna1 Tubg1 Cdk11b Ppp2r1a Ofd1 Dync1h1 Cep63 Cep152 Haus3 Haus4 Haus5 Haus6 Sfi1 Dync1i2 Csnk1d Haus1 Ckap5 Haus2 Akap9 Hsp90aa1 Cep164 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%R-HSA-3642279.3 TGFBR2 MSI Frameshift Mutants in Cancer Tgfb1 Tgfbr2 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 96%111458 Formation of apoptosome Diablo Mapk1 Apaf1 Mapk3 Apip Xiap Aven Uaca Casp9 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway Dlg1 Rasgrp3 Dlg3 Rasgrp1 Jak3 Il3ra Dlg4 Il2rb Tyk2 Csf2rb2 Csf2ra Il5 Il5ra Fnta Ppp1cb Fntb Spta1 Rbx1 Arl2 Sptb Ptk2 Sptan1 Ranbp9 Ptpn7 Ncam1 Itga2b Sptbn1 Sptbn2 Il2rg Sptbn4 Gdnf Gfra1 Lypla1 Camk2g Camk2d Camk2b Camk2a Abhd17b Abhd17a Abhd17c Rce1 Rasal1 Rasal2 Rasal3 Syngap1 Kbtbd7 Spred1 Spred3 Spred2 Rasa2 Rasa1 Rasa4 Rasa3 Nf1 Dab2ip Cul3 Ereg Hbegf Btc Epgn Rasgrf1 Rasgrf2 Il6 Nrg1 Egfr Flt3 Il17rd Wdr83 Rgl3 Rgl1 Klb Rgl2 Fgf16 Ppp2cb Fgf15 Pea15 Ppp2ca Shoc2 Irs1 Fgf18 Mras Irs2 Rapgef2 Fgf2 Fgf1 Fgf4 Fgf10 Rasgef1a Frs3 Fgf3 Angpt1 Fgf6 Fgf7 Tek Fgf9 Fgf20 Grin2b Icmt Fgf23 Egf Fgfr4 Fgf22 Bcl2l1 Areg Pdgfb Ppp2r1b Ppp2r1a Il6ra Dusp4 Dusp7 Dusp6 Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Ppp1cc Ppp2r5e Psma4 Psma3 Psma6 Fn1 Psma5 Psma2 Tgfa Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Flt3l Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Prkcq Nrg2 Rasgrp4 Dusp2 Nrg4 Dusp5 Nrg3 Paqr3 Zdhhc9 Dusp1 Il2 Dusp10 Dusp9 Dusp8 Golga7 Mark3 Prkg2 Kit Dlg2 Actn2 Nefl Grin1 Grin2d Ptpra Artn Erbb2 Gfra2 Kras Gfra3 Gfra4 Jak1 Brap Pik3r1 Phb1 Pik3r2 Apbb1ip Arrb2 Iqgap1 Arrb1 Jak2 Fgb Fga Rap1b Pspn Ksr1 Nrtn Vwf Cnksr2 Cnksr1 Fgg Araf Itgb3 Pebp1 Raf1 Tln1 Map3k11 Vcl Pdgfrb Ret Cdk1 Src Pik3cb Dusp16 Hgf Met Shc3 Pik3ca Shc2 Shc1 Mapk1 Braf Mapk3 Ywhab Mapk12 Rap1a Frs2 Ralgds Map2k2 Csf2 Nras Map2k1 Lamtor2 Sos1 Hras Ptpn11 Fyn Csk Pde6d Ppp5c Il2ra Pdgfra KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway Sp1 Psma4 Psma3 Psma6 Prdx1 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Skp1 Psmb5 Fbxl17 Psmb4 Psmb7 Psmb6 Slc7a11 Psmb1 Psmb3 Psmb2 Rela Btrc Notch1 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Map1lc3b Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Idh1 Prkaa2 Myc Akt3 Txnrd1 Akt2 Akt1 Eif2ak3 Csnk2a2 Mul1 Abcc3 Atf4 Sesn1 Dpp3 Mafg Gclc Gclm Me1 Abcf2 Palb2 Chd6 Gsta3 Ccl12 Trim21 Srxn1 Nqo1 Brca1 Tkt Ubxn7 Sod3 Cul3 Cdkn2a Sqstm1 Txn Vcp Skp2 Cdkn1a Abcg2 Abcc1 Pgd Amer1 Csnk2b Gsk3b Sesn2 Prkci Egf Bcl2 Pdgfa Bcl2l1 Areg Ep300 Hmox1 G6pdx Prkcd Ufd1 Nploc4 Mafk Bach1 Taldo1 Nfe2l2 Crebbp Keap1 REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 96%888593 Reuptake of GABA Slc6a1 Slc6a11 Slc6a13 Slc6a12 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 96%5579020 Defective SLC35D1 causes SCHBCKD Slc35d1 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle Jup Tfrc Pak1 Lck Pak4 Pak2 Lamtor1 Tuba1b Osbpl11 Dbn1 Nsfl1c Csk Fam91a1 Rab7 Pak6 Arhgdib Ralgapa1 Arhgdia Pak5 Wdr11 Arhgdig Dbt Rock2 Vcp Rock1 Slc1a5 Slc4a7 Vamp3 Zap70 Nipsnap2 Tmem59 Cav1 Mtr Stom Vangl1 Rhoh Uaca TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 96%9839406 TGFBR3 regulates activin signaling Inha Tgfbr3 Acvr2a Inhba PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-HSA-212300.4 PRC2 methylates histones and DNA Eed Phf1 Mtf2 Ezh1 Jarid2 H2bc14 Phf19 Epop H2bc9 H2bc7 H2ac20 H2bc8 H2bc3 H2bc21 H2bc26 Rbbp4 Rbbp7 H2ab2 H2bu2 H2ac12 H2ac11 Aebp2 Dnmt3a H2ac15 Dnmt3b H3c7 Dnmt1 Ezh2 H2ax Suz12 Hist1h2bp Hist2h2aa1 H2aj DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 Abca3 RAB GERANYLGERANYLATION%REACTOME DATABASE ID RELEASE 96%8873719 RAB geranylgeranylation Rab21 Chml Rab8a Rab3a Rab22a Rab12 Rab18 Rab11a Rab4a Chm Rab2a Rab11b Rab33b Rab42 Rab33a Rab2b Rab30 Rab35 Rab34 Rab37 Rabggta Rab36 Rab9 Rabggtb Rab5a Rab5c Rab8b Rab43 Rab5b Rab1a Rab1b Rab4b Rab3c Rab3b Rab3d Rab9b Rab20 Rab24 Rab23 Rab26 Rab25 Rab29 Rab40b Rab17 Rab19 Ptp4a2 Rab27a Rab6b Rab6a Rab7 Rab27b Rab39b Rab31 Rab10 Rab32 Rab13 Rab39 Rab14 Rab38 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells Cbfb Lgals3 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 96%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes Cdc34 Ube2g2 Usp7 Ube2g1 Ube2e3 Usp9x Uba1 Ube2c Ube2b Ube2d1 Ube2w Uchl3 Ube2k Ube2e1 Ube2l3 Ube2h Ube2a Ube2q2 Usp5 Ubc Ube2z Otulin Ube2t Ube2r2 Uba6 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 96%5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Ap2a2 Ap2a1 Cltb Fzd2 Fzd5 Ap2b1 Wnt5a Ap2s1 Clta Ap2m1 Cltc Ror1 Ror2 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 96%9845619 Enhanced cleavage of VWF variant by ADAMTS13 Adamts13 Vwf RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-611105.8 Respiratory electron transport Cox14 Cox8a Ndufv2 Ndufv1 Ndufv3 Cox16 Cox18 Tmem177 Ndufc1 Ndufc2 Cox7b Ndufs1 Ndufs2 Ndufs5 Ndufs7 Ndufs8 Foxred1 Ndufa1 Ndufa3 Ndufa2 Ndufa7 Ndufa6 Ndufa9 Ndufa8 Ndufb2 Ndufb3 Ndufb6 Etfa Ndufb5 Ndufb7 Ndufb9 Cox5a Etfb Mdh1 Mdh2 Slc25a18 Slc25a11 Slc25a22 Slc25a12 Slc25a13 mt-Nd4 mt-Nd5 mt-Nd6 mt-Nd1 mt-Nd2 mt-Nd3 Hspa9 Cox15 mt-Co1 Cox4i1 Cox4i2 Cox19 Cox17 Timm21 Ndufb8 Got1 Got2 Higd1c mt-Co2 mt-Co3 Cyc1 Ndufab1 Uqcrq Lyrm7 Hscb Uqcrc2 Uqcrc1 Lyrm4 Uqcrfs1 Uqcc2 Uqcc3 Uqcrb Uqcc1 Uqcc6 Uqcr10 Cox6a1 mt-Cytb Cox6a2 Fxn Bcs1l Ttc19 Uqcrh Oxa1l Cox6b1 Cox6b2 Coxfa4 Smim20 Nubpl Cmc1 Tmem223 Sco1 Coq10a Etfdh Coq10b Rab5if Trap1 Sfxn4 Ecsit Surf1 Higd2a Ndufa12 Ndufa10 Timmdc1 Ndufa13 Ndufb11 Ndufb10 Hccs Lyrm2 Dmac2 Dmac1 Ndufaf7 Ndufaf6 Ndufaf5 Tmem186 Ndufaf4 Ndufaf8 Sdhd Sdhc Ndufaf3 Sdhb Cox7a1 Sdha Cox7a2 Ndufaf2 Ndufaf1 Letm1 Tmem126b Tmem126a Acad9 Cox20 Taco1 Ndufa5 Coa3 Cox7a2l Cox11 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 Hey2 Hey1 Psma4 Flt4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Mamld1 Notch1 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Kat2b Psmd7 Psmd6 Kat2a Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Smad3 Akt1 Dll4 Hes1 Notch4 Jag1 Adam10 Ep300 Ywhaz Notch2 Psen1 Psen2 Ncstn Maml1 Aph1b Maml2 Hes5 Rbpj Crebbp Tacc3 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 96%9638482 Metal ion assimilation from the host Hbbt1 Hba-a1 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%211945 Phase I - Functionalization of compounds Cyp51a1 Mtarc2 Mtarc1 Fmo1 Aoc3 Cyp2r1 Aoc2 Cmbl Nqo2 Cyb5r3 Cyp2u1 Cyp1b1 Cyp4a32 Cyp2w1 Cyp4f15 Cyp2s1 Ahr Cyp2d22 Cyp3a16 Cyp3a13 Cyp3a57 Adh4 Cyp2c65 Cyp2c55 Aldh1b1 Aoc1 Acss2 Cyp2j6 Adh1 Cyp2f2 Aldh2 Cyp2e1 Hsp90ab1 Cyp1a1 Adh7 Acss1 Cyp2b10 Adh5 Ahrr Cyp4f14 Cyp2c50 Maob Ptgis Cyp1a2 Tbxas1 Cyp2a5 Cyp8b1 Cyp4v3 Aldh1a1 Cyp39a1 Por Cyp11b1 Ces3b Cyp27b1 Cyp46a1 Ces1d Ces2h Nr1h4 Cyp4f39 Cyp4f17 Cyp27a1 Cyp24a1 Cyp7a1 Cyp4a12b Cyp7b1 Cyp4f3 Cyp4f40 Cyp4b1 Fdx1 Paox Fdxr Fdx2 Ptgs1 Rxra Cyp19a1 Maoa Arnt Cyp21a1 Cyp11b2 Pomc Cyp26b1 Cyp26c1 Ncoa2 Cyb5b Cyp26a1 Ncoa1 Cyp11a1 Ephx1 Aadac Aip Bphl Aldh3a1 Cbr3 Fmo3 Fmo2 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 Rnf2 Eed Rbbp8 Apaf1 Brca1 Cdc7 Yaf2 Pcgf6 Rbbp4 Ehmt2 Pcgf2 Rbbp7 Ehmt1 Ring1 Phc1 Mga Tfdp2 Tfdp1 Ezh2 Rybp Phc3 E2f6 Suz12 Uxt E2f1 Chek1 Rrm2 Max Epc1 Bmi1 Cbx5 L3mbtl2 Cbx3 Rad51 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis Isca2 Glrx5 Fxn Slc25a37 Slc25a28 Fdx1 Hscb Fdxr Fdx2 Lyrm4 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 96%1482801 Acyl chain remodelling of PS Pla2g2e Pla2g2d Pla2g4a Pla2g2f Pla2g4d Lpcat4 Pla2g12a Pla2g5 Pla2g1b Pla2r1 Pla2g4f Pla2g4e Osbpl10 Lpcat3 Pla2g10 Mboat1 Osbpl5 Plaat3 Pla1a Osbpl8 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-HSA-1660661.12 Sphingolipid de novo biosynthesis Mfsd2b Vapb Ormdl3 Prkd3 Sptssa Sptssb Prkd1 Prkd2 Cers6 Cers5 Cers4 Cers3 Cers2 Sgms1 Sgms2 Sptlc1 Sptlc2 Sptlc3 Fa2h Sphk2 Kdsr Lass1 Ormdl1 Sphk1 Ormdl2 Degs2 Cyb5b Samd8 Ppm1l Osbp Vapa Abcg2 Csnk1g2 Abcc1 Degs1 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development Prkaca Ncor2 Sin3a Hdac3 Ncor1 Gps2 Tbl1xr1 Camk4 Hdac1 Tbl1x METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins Csf2rb2 Csf2ra B3gnt9 B3gnt8 Qtgal B3gnt6 B3gnt5 Galntl5 Galnt2 Galnt5 Galnt4 Galnt7 Galnt6 Galnt10 A4gnt Galnt17 Galnt18 Galnt15 Galnt16 Galnt13 Galnt14 Apoa2 Galnt11 Gcnt7 Gcnt3 Chst4 Apoa4 Gcnt1 Apoa5 Afg3l2 Smdt1 Vdac2 Gpihbp1 Yme1l1 Vdac3 Spg7 Micu2 Pmpca Vdac1 Alb Pcsk9 P4hb Hspg2 Sdc2 B4galt4 B4galt5 B4galt6 B4gat1 B4galt1 B4galt2 B4galt3 Bmp4 B3gnt7 B3gnt4 B3gnt2 Rab10 Rab13 Rab14 Mgat5b Gpc3 Slc17a5 Star St6galnac6 Tnc Fbn1 Lep Hk1 Alg9 Alg8 Alg6 Alg3 Alg2 Alg1 Mpdu1 Rft1 Dpagt1 Gata6 Hsd17b10 Mmp2 B4galnt2 St3gal6 Traf3 Ikbke Aldh1b1 Aldh2 Vgf Neurl2 Commd8 Mta1 Commd9 Wsb2 Fem1b Tulp4 Fem1c Dcaf8 Dcaf4 Topors Dcaf5 Dcaf6 Pum2 Ccdc22 Hif3a Dda1 Ccdc8 Fem1aa Commd4 Commd5 Commd6 Commd7 Commd1 Commd2 Commd3 Spsb3 Ankrd9 Galnt1 Commd10 Socs5 Socs6 Ubd Nae1 Wdtc1 Dcun1d5 Dcun1d4 Dcun1d3 Dcun1d2 Dcun1d1 Cul9 Dcaf17 Dcaf10 Dcaf11 Ercc8 Pdha1 Mrpl10 Mrpl54 Dap3 Mrpl11 Mrpl55 Tsfm Mrpl12 Gfm1 Mrpl13 Pdk1 Mrpl57 Pdhb Mrpl58 Mrpl14 Mrps30 Mrpl16 Mrps31 Mrpl17 Mrps33 Mrpl18 Mrpl19 Aurkaip1 Mrps34 Mrps35 Tufm Dlat Gadd45gip1 Me2 Mrpl20 Mrpl3 Mrpl43 Mrpl4 Mrpl44 Mrpl1 Mrpl46 Mrpl2 Mrpl47 Cma1 Mrpl48 Mrpl49 Mrps21 Mrps22 Mrps23 Mrps24 Mrpl9 Mrps25 Serpinc1 Mrps26 Bace1 Mrps27 Mrps28 Mfge8 Tspan5 Mrps18c Mrps18b Odam Mrps18a Itm2b Ttr Mrpl50 Sncaip Mrpl51 Tspan33 Mrpl52 Calb1 Mrpl53 Apcs Mrpl32 H2az1 Mrpl33 Tspan14 Oxa1l Tspan15 Mrpl34 Tgfbi Mrpl35 Mrps9 Cst3 Mrpl36 Nat8 Sorl1 Mrpl37 Mrpl38 Mrpl39 Mrps10 Mrps11 Mrps12 Ero1b Ces1d Mrps14 Chchd1 Crhr2 Cpa3 Mrps15 Kif5c Mrps16 Mrps17 Mme Kif5b Ptcd3 Mrps2 Enpep Mrps6 Mboat4 Mrps7 Atp6ap2 Mrpl40 Gzmf Dpp4 Mrpl41 Mrps5 Pla2g7 Slc30a5 Mrpl21 Ace Mrpl22 Cltrn Mrpl24 Cdx2 Mrpl28 Eral1 Slc30a8 Anpep Mrpl30 Pcsk1 Pcsk2 Gpr119 Cpe Inhbb Cpb1 Inhbc Inhbe Rhoa Tfam Lman1 Rab7 Shmt2 Arfgap3 Arf3 Stx5 Ykt6 Ktn1 Fstl1 Gmppa Pmm2 Mpi Gmppb Pmm1 Abca3 Dag1 Isl1 Gspt2 Gspt1 Cul2 Pabpc1 Usp33 Etf1 Ckap4 Amdhd2 Gnpnat1 Srd5a3 Pgm3 St6galnac5 Cmas Dhdds Nudt14 Alg5 Slc35a1 Mmp1a Dolpp1 Fuom Dpm1 Dpm2 Dpm3 Gmds St6gal2 Renbp Ctsa Gne St8sia6 St8sia4 St8sia5 Uap1 Dolk Npl Neu2 Neu3 Neu4 Il33 Nagk Fcsk Gfpt1 Gfpt2 Neu1 Dhrsx St6galnac1 Nus1 Slc35c1 St3gal5 Nanp Fpgt Gfus St8sia2 Nans St8sia3 St8sia1 Ace2 Sqstm1 Arf1 Arfgap2 Ctsz Hspa8 Trmt112 Hemk2 Mat2b Adra2a Adra2c Fgf23 Lrr1 Man1a Man1a2 Fbxl20 Man1c1 Wsb1 Eci1 Ccnf Ube2l6 Rnf123 Rab39b Rab31 Rab32 Rab39 Rab38 Siah2 Keap1 Kbtbd13 Ube2g2 Ube2g1 Rab21 Kbtbd8 Gan Chml Fbxw8 Klhl9 Klhl2 Spsb2 Rab12 Rab18 Spsb1 Spsb4 Ube2j2 Kctd7 Ube2w Ube2m Ube2k Ltn1 Ube2h Ube2f Ube2a Fbxo10 Fbxo11 Tada3 Fbxo17 Lmo7 Lrrc41 Klhl13 Ube2z Klhl11 Pnpla2 Fbxo21 Fbxo22 Fbxo27 Ube2v2 Uba6 Klhl25 Ube2e3 Btbd6 Fech Klhl21 Klhl22 Klhl20 Alas1 Fbxl8 Fbxo30 Fbxo31 Fbxl4 Fbxl7 Zbtb16 Uba1 Uba3 Cul5 Actr10 Cul7 Fbxo41 Dctn5 Dctn6 Dctn4 Fbxo44 Capza3 Klhl41 Klhl42 Fbxo40 Ube2q2 Btbd1 Fbxo2 Asb12 Asb11 Siah1a Asb14 Asb13 Asb16 Asb15 Asb18 Asb17 Herc2 Ube2r2 Rnf7 Fbxo7 Fbxo9 Vhl Fbxl12 Fbxl13 Fbxl14 Fbxl15 Fbxl16 Fbxl18 Fbxl19 Asb9 Asb8 Asb7 Asb6 Asb5 Asb4 Asb3 Asb2 Rchy1 Asb1 Ctbp1 Dnmt3a Dnmt3b Dnmt1 Ncstn Aph1b Polb Adora2b Myo5a Nlrp3 Ctsg Gnat3 Rnf146 Tnks2 Tnks Trim27 Otud3 Usp13 Camkmt Nsf Gria1 Pax6 Ripk2 Tnip2 Saa3 Nod2 Nod1 Usp14 Usp18 Chgb Eva1a Dmp1 Ccn1 Shisa5 Amelx Pappa Lgals1 Scg2 Meltf Mxra8 Fam20a Fam20c Fuca2 Stc2 Serpina10 Hrc Ambn Actr1a Mepe Mia3 Pappa2 Enam Bmp15 Bpifb2 Dctn2 Igfals Dctn3 Igfbp6 Matn3 Rab11a Rcn1 Vwa1 Fstl3 Prss23 Tmem132a Exoc3 Afp Exoc4 Igfbp2 Exoc5 Igfbp5 Igfbp4 Exoc6 Golm1 Exoc1 Amtn Exoc2 Serpind1 Nucb1 Exoc7 Sparcl1 Exoc8 Msln Itih2 Notum Klk13 Trrap Arf4 Ctsh Eif5b Eif5 Csnk1d Rnf103 Amfr Rnf139 Marchf6 Trim13 Uggt1 Uggt2 Edem3 Ccp110 Gbf1 Cetn2 Rab8a Uqcrq Uqcrc2 mt-Cytb Rab9 Rab43 Rab9b Cog1 Cog2 Cog3 Cog4 Cog6 Cog7 Cog8 Napa Napb Napg Rab6b Rab6a Sars1 Stard7 Ddx5 Ctsd Spta1 Sptb Ank3 Ank1 Sptan1 Sptbn1 Sptbn2 Usp10 Manea Sptbn4 Otulin Ache Rce1 Gars1 Lars2 Nars2 Tars2 Iars2 Cars2 Vars2 Ears2 Bche Wars2 Aars2 Rars2 Pars2 Ppa2 Mars2 Rab3a Dars2 Yars2 Sars2 Hars2 Fars2 Nfrkb Ino80e Tfpt Ino80d Ino80c Ino80b Actr5 Actr8 Ruvbl1 Xpc Rad23a Rad23b Cops3 Cops6 Cops8 Ino80 Cops7a Cops7b Bdh1 Oxct1 Hmgcs2 Acat1 Twnk Ssbp1 Eif3m Eif3i Eif3l Eif3k Eif3f Eif3e Eif3h Eif3g Eif3b Eif3a Eif3d Eif3c Eif4h Eif3j2 Eif1ax Eif4a2 Eif4a1 Sftpb Clspn Trp53bp1 Abraxas1 Brcc3 Rnf168 Oma1 Opa1 Rad52 Babam1 Babam2 Uimc1 H2ac21 H2ac25 Hist1h2af Prmt3 H2ac1 Hsp90b1 Ttll6 Ttll7 Ttll4 Ttll5 Ttll3 Ttll1 Ttl Ttll9 Ttll10 Nicn1 Agbl5 Agbl1 Agbl2 Agbl3 Ttll11 Ttll12 Agtpbp1 Lrrc49 Svbp Vash1 Psma4 Vash2 Tpgs1 Prkdc Psma3 Tpgs2 Psma6 Psma5 Psma2 Psma1 Ikbkg Ctsc Map3k7 Scfd1 Ppp6r1 Psmd12 Ppp6r3 Psmd11 Lman2 Psmd14 Psmd13 Sec22c Sec22b Sec22a Skp1 Tfg Psmb5 Preb Psmb4 Trappc6b Psmb7 Ppp6c Psmb6 Rab2a Trappc9 Psmb1 Trappc6a Psmb3 Trappc5 Psmb2 Trappc4 Fbxw11 Sec31b Trappc3 Rela Sec31a Trappc2 Btrc Trappc1 Psma7 F5 Psmc6 F8 Psmc5 Rab1a Psmc2 Stx17 Psmc1 Rab1b Psmc4 Trappc2l Psmc3 Gosr2 Ubc Lman1l Tbc1d20 Bcl10 Psmd7 Cd59b Uso1 Psmd6 Sec23ip Trappc10 Psmd8 Sec16b Psmd3 Sec16a Psmd2 Mcfd2 Psmd1 Lman2l Serpina1d Nfkbia Adrm1 Cnih1 Sem1 Gorasp1 Cul1 Cnih3 Cnih2 Folr1 Ankrd28 Nr3c2 Bet1 Nr3c1 Thrb Nr2c1 Vdr Sumo3 Nr1h2 Rora Ppara Esr1 Pparg Pias3 Pias4 Ar Rxra Hdac4 Timm9 Ube2i Rara Pgr Nr5a1 Pias1 Nr4a2 Aco2 Timm10 Pcna Cs Timm22 Ldhd Blm Bard1 Wrn Palb2 Rpa1 Acad8 Acadsb Brca1 Usp30 Stambpl1 Otud7a Rab22a Gp2 Fuca1 Zranb1 Rhot1 Spaca4 Gcsh Ube2c Ndufab1 Ptrh2 Crppa Cdk1 Abraxas2 Chst8 Ube2d1 Ly6g6c Ly6g6d Wdr20 Ube2e1 Pgap1 Arcn1 Rab42 Stam2 Atxn7 Rab2b Rab30 Rab34 Stam Rab37 Ctnnb1 Rab36 Usp3 Usp5 Rxylt1 Hgs Ly6k Rab4b Bet1l Rab3c Ntng1 Rab3b Rab3d Ly6h Ly6d Cpm Tex101 Rab20 Fkrp Rab24 Rab23 Rab26 Rab25 Rab29 Rab40b Psca Rab17 Rab19 Mdga1 Folr2 Mdga2 Pyurf Nfu1 Yod1 Mettl21A Fktn Mettl22 Adrb2 Rnf128 Nrn1l Gpaa1 Eef2kmt Umod Fkbp8 Lias Otoa Mlec Prss21 Prss41 Alppl2 Engase Pomgnt2 Pofut2 Pofut3 Pofut4 Ntm Nrip1 Xpnpep2 Ep300 Stambp Emid1 Copa Cntn3 Cntn5 Lypd6b Xrcc4 Otub1 Lipt1 Bap1 Lipt2 Hdac3 Usp44 Usp42 Ncoa2 Usp49 Ncoa1 Usp48 Usp47 Cope Otub2 Ngly1 Usp37 Gosr1 Eef1akmt2 Ubxn1 Mysm1 Eef1akmt1 Tnip3 Tnip1 Mmrn2 Usp22 Usp20 Ppargc1a Nfe2l2 Usp26 Usp25 Crebbp Usp28 Pomk Otud5 Apoa1 Usp12 Usp16 Usp19 Apob Gpld1 Thy1 Kdelr2 Etfbkmt Pigc Pigb Suds3 Piga Pigk Pigm Pigl Pigg Pigf Pigh App Copz2 Copz1 Arf5 Golga2 Asgr2 Asgr1 Pigs Pigu Pigt Pigo Pign Pigz Pigw Pigx Rtn4rl2 Tecta Rtn4rl1 Tectb Vcpkmt Cdc25a Sprn Slc35a4 Vcpip1 B3galnt2 Reck Etfb Chst10 Alg10b Tmem115 Rbx1 Nrn1 Art4 Ucn Art3 Snx3 Bst1 Tmed9 Kin Izumo1r Lsamp Tmed3 Iapp Copg1 Copg2 Ube2t Negr1 Opcml Large2 Prnd Copb2 Lypd8 Gip Lypd5 Lypd4 Lypd3 Lypd2 Copb1 Lypd1 Alpl Plaur Ptp4a2 mt-Nd4 mt-Nd5 Gsn mt-Nd6 Gfm2 mt-Nd1 Gng10 mt-Nd2 mt-Nd3 Mrrf Mtrf1 Sftpc Mtrf1l mt-Nd4l Gng3 Gng2 Gng4 Gng7 Gng8 Gngt1 Gngt2 Gcg Gnb2 Gnb1 Gnb4 Ascc3 Gnb3 Ascc2 Gnb5 Gng11 Adgrf5 Dmbt1 Sftpa1 Gng12 Lmcd1 Gng13 Napsa Ccdc59 Kbtbd7 Cul3 Abce1 Pelo Cdc73 Rtf1 Rnf181 Shprh Tmem129 Leo1 Skic8 Selenos Vcan Pex2 Glb1 Rnf152 Rnf40 Pex14 Pccb Rnf144a Pex13 Pex12 Hltf Arsb Pex10 Wac Ccne1 Ctr9 Ccne2 Paf1 Skp2 Lonp1 Htra2 Pros1 Cdkn1a Daxx Ly6e Gas6 Smc3 Nup37 Nup160 Cdc20 Mgat3 Nup43 Rab27a Ranbp2 Rad21 Dync1li2 Myrip Dync1li1 Nup107 Nadk2 Dynll1 Dynll2 Rps27 Stag2 Stag1 Dync1h1 Birc5 Nup85 Cdca8 Incenp Dync1i2 Ppa1 Dync1i1 Aurkb Sec13 Ano8 Nup133 Smc1a Hic1 Prl Sp3 Foxl2 Apeh Cdh2 Fdx1 H2ac20 Myc Rpn2 Rpn1 Hif1a Tcf7l2 Cftr H2ac12 H2ac11 H2ac15 Park7 H3c7 H2ax B3gnt3 Csnk2a2 Axin2 Suz12 Nfkb2 Hist1h2bp Os9 Sel1l Magt1 H2bc9 H2bc7 H2bc8 H2bc3 Stat3 Tmem258 Hadh H2ab2 Rnf185 Derl2 Proc Derl1 Ifih1 H2bu2 Rnf135 Trim25 Stt3a Mavs Stt3b Rigi Vcp Rab5a Ostc Rab5c Rab5b Cops5 Tusc3 Hist2h2aa1 Dad1 Epas1 Wdr5 Ddost Csnk2b H2bc14 Rnf5 Suclg2 H2bc21 H2bc26 Rbbp5 Rbbp7 Ndufa13 Fh Eloc Idh2 Ndufv1 Ndufv3 Pfdn6 Cct6a Pfdn5 Ndufs1 Pfdn4 Tuba1b Tuba1a Galnt3 Pfdn2 Muc15 Pfdn1 Tuba1c Muc13 Gba1 Pomgnt1 Tubal3 Galnt12 Adamts1 Ndufa2 Rgs9 Adamts5 Rgs6 Adamts4 Rgs7 Adamts3 Cct3 Adamts2 Cct2 Adamts8 Skic2 Tubb2b Adamts7 Adamts6 Idh3a Vbp1 Kif13a Sema5a Tubb2a Sema5b Ndufb6 C1galt1 Fkbp9 Fbxw10 Thsd1 Actb Thbs2 C1galt1c1 Fbxw4 Thsd4 Fbxw5 Adamts13 Fbxw7 Adamts14 Fbxw9 Adamts15 Xrn2 Sphk1 Large1 Tcp1 Adamts16 Srp68 Tuba4a Cfp Ssr4 Cct6b Adamts18 Ssr3 Adamts19 Ssr2 Fbxw2 Spon2 Gna11 Srp72 Gna15 Muc1 Srp9 Spon1 Gna14 Tram1 Adamts10 Tbcd Srp14 Sbspon Arl2 Srp54 Adamts12 Tbcc Srp19 B3glct Fbxo4 Muc4 Gapdhs Muc6 Tbcb Thsd7a Tbca Fbxo6 Muc20 Tuba8 Adamtsl1 Adamtsl2 Lonp2 Adamtsl3 Arfgef2 Adamtsl4 Gnaq Tbce Adamtsl5 Pomt1 Pdcl Tuba3b Adamts20 Thsd7b Cct8 Cct7 Pomt2 Cct5 Cct4 Dcaf7 Wrap53 Tubb6 Tubb3 Trp53 Tubb1 Rgs11 Fbxl3 Fbxl5 Ap3m1 Nop56 Tubb4b Tubb4a Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup188 Tpr Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Slc25a5 F2 Grp Rps14 Agt Rpl4 Rps16 Rps18 Rps19 Eif2ak2 Rpsa Rpl37 Rpl39 Rps10 Rps11 Rpl7 Rpl32 Rps9 Rps7 Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Ffar4 Tgfb1 Ffar1 Rps25 Rps26 Kng2 Rps21 Rpl39l Rps15a Dnajc3 Parp1 Calr Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Glud1 Canx Rps3 Rps4x P2ry2 Alg14 Znf598 Ankzf1 Klhdc10 Tcf25 Ogdh Dlst Vnn1 Vnn3 Amer1 Tpst1 Tpst2 Riox1 Riox2 Kdm8 Dhps Eif5a Rwdd1 Fn3k Fn3krp Proz F7 Eif5a2 Jmjd4 F9 Jmjd6 Sumf1 Sumf2 Arsa Icmt Wars1 Dohh Aars1 Mief1 Rccd1 Mtres1 Ggcx Dph1 Hars1 Dph2 Tars1 Yars1 Dph3 Cars1 Dnajc24 Dph5 Mtfmt Dph6 Nars1 Vars1 Dph7 Zc3h15 Farsa Farsb F10 Ogfod1 Mtif3 Arsk Mtif2 Arsj Drg1 Arsi Drg2 Arsg Cpb2 Arfgap1 Fn1 Lamb2 Lamc1 Lamb1 B2m H2-Q10 Psme4 H2bc18 Psme3 Psme2 Mdh2 Psme1 Psmd10 Psmb11 Psmb10 Pomp Psmf1 Psmg2 Psmg1 Psmg4 Becn1 Psmg3 Psmb9 Psmb8 Psmd9 Psmd5 Psmd4 Traf6 Ube2n Cdc34 Ide Tab1 Lars1 Mitf Eef1e1 Kars1 Hdac1 Ech1 Acot2 Mars1 Csf1 Dars1 Qars1 Rars1 Socs2 Pomc Cish Aimp2 Aimp1 Eprs1 Iars1 Cga Tshb Hnrnpk Sftpd Cops4 Cops2 Sec11c Sec11a Hnrnpc Rnf20 Ltf Tomm70 Furin Kdelr1 Tgfbr1 Tgfbr2 Eif4ebp1 Eif4g1 Rraga Eif4b Eif4e Vamp2 Stx1a Apc Slc34a1 Slc34a2 Sar1b Ufd1 Arg2 Sec23a Nploc4 Mvd Spcs3 Spcs1 Spcs2 Pdia3 Sec24d Sec24c Mbtps1 Sec24b Sec24a Birc3 Birc2 Traf2 Prkn Ube2l3 Smc6 Smc5 Ripk1 Ddx17 Nsmce4a Casp8ap2 Eid3 Uhrf2 Mrtfa Senp1 Senp2 Nsmce1 Ogt Nsmce3 Nsmce2 Uba2 Sae1 Safb Top2b Top2a ATP6 Top1 Senp5 Mbd1 Satb1 Atp5f1c Nop58 Atp5pf Hspa9 Atp5f1b Atp5f1a Ddb1 Wdr48 Ube2b Cul4a Rad18 Cul4b Dtl Mul1 Asph Dpp3 Prkaca Ubxn7 Cdkn2a Txn Il6 Ring1 Cbx8 Phc2 Phc1 Cbx4 Cbx2 Phc3 Mdm2 Mdm4 Ccna1 Ccna2 Bmi1 Igfbp7 Rnf2 Areg Eef1a2 Eef1d Eef1g Eef1b Eef2 Snca Adam10 C3 C4a Alpi Eif2b3 Eif2b2 Eif2b5 Eif2b4 Eif2s3x Eif2b1 Eif2s2 Eif2s1 Gga2 Gga1 Rab4a Gga3 Cop1 Rab11b Oxsm Aldh18a1 Rab33b Clpp Rab33a Clpx Msra Pcmt1 Rab35 Msrb1 Msrb3 Msrb2 Rab8b Ganab Mgat5 Man2a1 Mgat2 Mgat1 Mogs Edem2 Igf2 Fut8 Igf1 St6galnac3 St6galnac4 St6galnac2 St3gal4 Syvn1 Mgat4c Mgat4a St3gal2 Mgat4b St3gal1 Man1b1 Prkcsh St6gal1 Kdm1b Zdhhc2 Adora2a Axin1 Gata3 Gata4 mt-Co2 mt-Co3 Chm Ing2 Lhb Fshb Kat2b Kat2a Atxn3 Socs3 Penk Men1 Usp2 Usp7 Tfap2c Tfap2b Sin3a Klf4 Pml Sec61a2 Ins2 Sec61a1 Sec61b Actl6a Capzb Capza1 Capza2 Inha Timp1 Inhba Satb2 Ltbp1 Uchl5 Usp15 Usp8 Ttf1 Ube2d3 Fbxo32 Cbx5 Aurka Trim28 Mdc1 L3mbtl2 Ddb2 Usp9x Ncor2 Pcgf2 Dcaf13 Spp1 Yy1 Hipk2 Rabggta Rabggtb Hdac2 Cd109 Hdac7 Triap1 Pten Calu Rab27b Ahsg Spp2 Thbs1 Scg3 Qsox1 Apoe Foxo4 Aplp2 Mmrn1 Plg Tgfa Smurf2 Foxk2 Foxk1 Uchl3 Hcfc1 Senp8 Asxl1 Uchl1 Cox5a Mbd6 Asxl2 Npm1 Kctd6 Golgb1 Smad1 Smad2 Smad3 Smad4 Nppa Smad7 Alg11 mt-Co1 Srprb Srpra Cox4i1 Edem1 Hspd1 Dctn1 Pdia6 Prelid1 Chd3 Kdelr3 Igfbp3 Ssr1 Wfs1 Igfbp1 Arrb2 Arrb1 Fga Fgg Cp Tf Cand1 Josd2 Usp21 Usp4 Cyld Otud7b Nedd8 Tnfaip3 Dbt Dld Col7a1 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 96%112308 Presynaptic depolarization and calcium channel opening Cacnb1 Cacnb2 Cacna1e Cacng4 Cacna1a Cacng2 Cacna1b Cacna2d1 Cacna2d3 Cacna2d2 Cacnb3 Cacnb4 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives Ptgs2 Gpx4 Alox8 Alox15 Gpx2 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants Arrb1 Jak2 Fgb Fga Rap1b Map2k2 Ksr1 Vwf Cnksr2 Nras Cnksr1 Fgg Map2k1 Araf Mark3 Itgb3 Pebp1 Raf1 Hras Tln1 Map3k11 Fn1 Vcl Csk Itga2b Src Camk2g Camk2d Camk2b Kras Camk2a Mapk1 Braf Mapk3 Ywhab Rap1a Brap Phb1 Apbb1ip Arrb2 Iqgap1 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9955693 NAGS variants cause NAGS deficiency Nags UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 96%5210891 Uptake and function of anthrax toxins Pdcd6ip Map2k4 Map2k2 Furin Map2k1 Map2k7 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations Atrx Daxx SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 96%3108232 SUMO E3 ligases SUMOylate target proteins Nup133 Ikbkg Smc1a Ikbke Hic1 Sp3 Ddx5 Foxl2 Satb2 Rela Npm1 Mta1 Smc6 Smc5 Topors Ddx17 Nsmce4a Casp8ap2 Eid3 Uhrf2 Mrtfa Nsmce1 Nsmce3 Cbx5 Nsmce2 Nfkbia Safb Top2b Top2a Top1 Nr3c2 Mbd1 Nr3c1 Satb1 Trp53 Thrb Nop58 Nr2c1 Vdr Sumo3 Nr1h2 Rora Ppara Mitf Esr1 Pparg Pias3 Nup93 Pias4 Nup50 Nup35 Ar Trim27 Rxra Nup54 Hdac1 Pom121 Hdac4 Nup205 Ube2i Nup188 Rara Pgr Tpr Rae1 Nr5a1 Pias1 Ndc1 Nup42 Nr4a2 Nup62 Nup88 Aurka Trim28 Aaas Nup214 Nup210 Nup155 Nup153 Chd3 Pcna Mdc1 Park7 Suz12 Blm Nfkb2 Eif2ak2 L3mbtl2 Wrn Herc2 Rpa1 Cetn2 Vhl Brca1 Cdkn2a Hnrnpk Ncor2 Parp1 Pcgf2 Xpc Ring1 Ing2 Cbx8 Phc2 Hnrnpc Hipk2 Phc1 Cbx4 Cbx2 Phc3 Mdm2 Daxx Bmi1 Ctbp1 Smc3 Nup37 Nup160 Rnf2 Nup43 Ranbp2 Rad21 Tfap2c Hdac2 Tfap2b Nup107 Hdac7 Trp53bp1 Nrip1 Stag2 Rnf168 Stag1 Ep300 Rad52 Xrcc4 Sin3a Birc5 Dnmt3a Dnmt3b Ncoa2 Dnmt1 Ncoa1 Nup85 Cdca8 Incenp Aurkb Ppargc1a Crebbp Pml Sec13 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%75108 Activation of BID and translocation to mitochondria Gzmb Casp8 Bid Nmt1 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 96%977347 Serine metabolism Psat1 Serinc4 Phgdh Serinc5 Srr Serinc2 Serinc3 Serinc1 Sds Psph Sdsl CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%163765 ChREBP activates metabolic gene expression Acacb Mlx Acaca Acly Mlxipl Agpat1 Fasn INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%8854691 Interleukin-20 family signaling Il20 Jak2 Il24 Il22ra1 Il10rb Jak3 Tyk2 Ifnl3 Stat5a Stat5b Ptpn11 Il22b Il20rb Stat3 Il20ra Jak1 Stat1 Ifnlr1 Stat4 Il19 Stat2 Il22ra2 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes Chd6 Gsta3 Srxn1 Nqo1 Sod3 Atf4 Prdx1 Mafk Txnrd1 Gclc Bach1 Gclm Nfe2l2 Txn Crebbp Ep300 Hmox1 Slc7a11 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum Notch2 Notch3 Notch1 Pofut1 Notch4 Poglut1 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%212165 Epigenetic regulation of gene expression Zfp141 Actl6a Smarce1 Sap30l Suds3 Znf382 Sap30 Havcr2 Sap18b Arid4b Angptl4 Plin1 Mgll Cdk5 Fabp4 Actb Ncoa3 Lpin1 Nr5a2 Zfp317 Dgat2 Lipe Ttf1 Lpl Polr1b Polr1a Polr1g Polr1e Polr1h Sap30bp Taf1d Taf1a Taf1c Ogt Taf1b Cbx5 Sap130 Cbx3 Baz2a Ubtf Zfp457 Cd36 Suv39h1 Trim28 Dek Psip1 Setdb1 Zfp324 Aebp2 Atf7ip Ercc6 Zfp708 Mtrex Zfp354a Med23 Med24 Med20 Med27 Med12 Med13 Med14 Med10 Med16 Med17 Ncor2 Zcchc8 Ehmt2 Rbm7 Ehmt1 Mbd3 Pphln1 Rb1 Arid1a Arid1b Mybbp1a Med30 Med31 Ddx21 Ss18 Dpf1 Dpf2 Kmt2d Dpf3 Ss18l1 Kmt2b Bcl7a Bcl7b Bcl7c Hdac2 Mphosph8 Smarcb1 Morc2a Smarca2 Smarca4 Smarcd1 Cebpa Smarcd2 Smarcc2 Smarcc1 Ccnc Spocd1 Dnmt3l Rrp8 Phf20 Tasp1 Akap8l Pex11a Hcfc1 Kat8 Yeats2 Wdr82 Kat14 Hcfc2 Dr1 Phf20l1 Elovl5 Cidec Mta1 Tada3 Tada2a Mta3 Bod1 Zzz3 Ppargc1b Plin4 Acsl1 Mbip Kansl3 Kansl1 Kansl2 Pnpla2 Bod1l Thrsp Polr2h Phlda1 Sgf29 Polr2e Polr2f Polr2k Mnat1 Gtf2h2 Gtf2h1 Agpat2 Gtf2h4 Gtf2h3 Gtf2h5 Ercc2 Ccnh Adipoq Ercc3 Mbd2 Cdk7 H2ac20 Rxra Hdac1 Ube2i Piwil4 Cxxc1 Chd3 Chd4 H2ac12 H2ac11 Plin2 H2ac15 Zfp454 H3c7 Ezh2 H2ax Suz12 Ash2l Mta2 Hist1h2bp H2aj Pdk4 Med4 Med6 H2bc9 H2bc7 H2bc8 H2bc3 Gatad2a Gatad2b H2ab2 Polr1c Kdm6a Uhrf1 Tet3 Polr1d H2bu2 Gps2 Kat2b Kat2a Kmt2c Hist2h2aa1 Dpy30 Wdr5 Men1 Eed Phf1 Tet2 Tet1 Gsk3b Mtf2 Sf3b1 Ezh1 Jarid2 Phf19 H2bc14 Epop Setd1b H2bc21 Setd1a H2bc26 Pagr1a Rbbp5 Rbbp4 Ncor1 Abl1 Rbbp7 Paxip1 Ep300 Cdk8 Tbl1x Baz1b Ajuba ZNF418 Sin3a Sin3b Hdac3 Dnmt3a Scd1 Dnmt3b Ncoa2 Tbp Smarca5 Ncoa1 Dnmt1 Tbl1xr1 Smarcd3 Ncoa6 Med1 Ppargc1a Crebbp Sirt1 Gpam IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R Fgf16 Frs2 Fgf15 Them4 Irs1 Fgf18 Irs2 Fgf2 Pik3c3 Fgf1 Nras Irs4 Fgf4 Gab1 Fgf10 Igf2 Fgf3 Igf1 Fgf6 Sos1 Fgf7 Fgf9 Hras Trib3 Fgf20 Ptpn11 Gab2 Fgf23 Fgfr4 Fgf22 Akt2 Pde3b Tlr9 Pik3r4 Flt3l Pik3cb Igf1r Pik3ca Flt3 Pdpk1 Pik3r1 Pik3r2 Klb SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 96%166520 Signaling by NTRKs Nab1 Nab2 Ap2m1 Cdk5r1 Trib1 Arc Tph1 Cdk5 Id2 Id3 Fosl1 Egr3 Sgk1 Egr4 Dnal4 Lyl1 Ascl1 Rrad Ap2a2 Cdk5r2 F3 Ap2a1 Vgf Map2k5 Adcyap1 Ptprs Ap2b1 Ap2s1 Bax Dnm1 Dnm3 Jund Rps6ka1 Adora2a Chd4 Id4 Id1 Rest Adcyap1r1 Rac1 Fos Pik3r1 Pik3r2 Fosb Mapk7 Elk1 Ptpro Clta Stat3 Junb Ntrk3 Cltc Sh3gl3 Src Pik3cb Tcf12 Dnm2 Sh3gl2 Shc3 Pik3ca Shc2 Shc1 Mapk1 Braf Mapk3 Furin Crkl Pcsk5 Pcsk6 Ywhab Mapk12 Rap1a Rps6ka3 Mapkapk3 Rps6ka2 Mapk13 Mapkapk2 Mapk14 Rala Ralb Ppp2cb Frs2 Ppp2ca Ngf Irs1 Kidins220 Ralgds Irs2 Map2k2 Rit1 Tiam1 Rit2 Nras Bdnf Gab1 Ntrk1 Plcg1 Map2k1 Frs3 Rapgef1 Sos1 Ntf4 Egr2 Crk Ntrk2 Dock3 Hras Rhoa Ntf3 Mapk11 Grin2b Ptpn11 Rps6ka5 Atf2 Vrk3 Srf Ep300 Egr1 Ppp2r1b Ppp2r1a Nelfb Mef2d Dusp3 Dusp4 Dusp7 Dusp6 Mef2a Ppp2r5d Mef2c NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Akt1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Notch4 Psmb4 Psmb7 Ywhaz Psmb6 Psmb1 Psmb3 Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Sem1 Cul1 Tacc3 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 96%444257 RSK activation Mapk1 Mapk3 Rps6ka3 Rps6ka6 Rps6ka1 Pdpk1 Rps6ka2 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%451927 Interleukin-2 family signaling Jak2 Il2 Lck Csf2 Il3ra Jak3 Il2rb Ptk2b Ptpn6 Csf2rb2 Csf2ra Sos1 Il5 Stat5a Stat5b Il5ra Gab2 Grb2 Stat3 Stat1 Il2rg Inpp5d Sos2 Il9 Il9r Il2ra Inppl1 Pik3cb Il15ra Pik3cd Il21r Pik3ca Shc1 Jak1 Syk Stat4 Il15 Pik3r1 Pik3r2 Il21 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival Prkaca Cd3g Itpr3 Itpr2 Itpr1 Adora2b Ggt1 Prkx Plcg2 Dpep1 Dpep2 Prkacb Il6 Ggt5 Adcy3 Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Gnaz Fcgr1 Adcy9 Fcgr3 Fcgr4 Syk Furin Fgr Gnai2 Gnai1 Gnai3 Prkar1b Mapk14 Gnat3 Prkar2b Cysltr2 Cysltr1 Gng10 Plcg1 Fyn Gng3 Gng2 Prkar1a Gng4 Gng7 Gng8 Lyn Adam17 Yes1 Prkar2a Gngt1 Gngt2 Rhbdf2 Il10 Cd163 Plk2 Myh9 Ahcyl1 Gnb2 Gnb1 Hck Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 96%9609736 Assembly and cell surface presentation of NMDA receptors Actn2 Nefl Grin1 Kif17 Dlg1 Grin2d Dlg3 Grin2c Dlg4 Camk2g Camk2d Grin2b Cask Camk2b Camk2a Apba1 Lin7a Lin7b Lin7c Grin3b Grin2a Dlg2 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 96%5654696 Downstream signaling of activated FGFR2 Fgf16 Frs2 Fgf18 Fgf2 Fgf1 Nras Gab1 Fgf4 Plcg1 Fgf10 Frs3 Fgf3 Fgf6 Sos1 Fgf7 Fgf9 Hras Fgf20 Ptpn11 Pik3ca Fgf23 Fgf22 Pik3r1 MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 96%9683610 Maturation of nucleoprotein Parp6 Ube2i Gsk3a Parp8 Gsk3b Parp10 Parp9 Parp14 Parp16 Parp4 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) Sv2c Snap25 Sv2b Sv2a INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits Gng10 Kcnj3 Kcnj2 Gng3 Gng2 Gng4 Gng7 Gng8 Gabbr1 Gabbr2 Gngt1 Gngt2 Kcnj9 Kcnj6 Kcnj5 Kcnj4 Gnb2 Gnb1 Kcnj10 Gnb4 Gnb3 Gnb5 Gng11 Kcnj12 Gng12 Gng13 Kcnj15 Kcnj16 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 96%975577 N-Glycan antennae elongation Mgat5 B4galt6 B4galt1 B4galt2 B4galt3 St8sia2 St8sia3 St3gal4 Mgat4c Mgat4a Mgat4b St8sia6 St6gal1 B4galt4 B4galt5 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 96%1266738 Developmental Biology Col4a1 Pitpna Pbx1 Plxnd1 Nfatc1 Il12rb2 Col4a2 Col9a2 Nfatc2 Col9a3 Col6a6 Col6a3 Ppp3cb Col4a5 Col9a1 Il5 Jun Capn1 Angptl4 Cdk5r1 Ap2m1 Ywhae Cdk5 Capns1 Prkacb Foxo3 Cdc25b Ap2a2 Ap2a1 Notch1 Rbx1 Ihh Lpl Ap2b1 Shh Ap2s1 Iapp Wnt9b Wnt10b Wnt11 Il4 Il13 Dhh Fgfr1 Hoxa11 Hoxd11 Hoxc11 Grem1 Six1 Sdc2 Wnt3a Hoxa6 Npnt Foxc2 Foxc1 Gdnf Six2 Id4 Wnt1 Pcdh19 Wnt4 Gfra1 Pou3f3 Irx1 Irx2 Emx2 Plac8 Osr1 Hoxb4 Pax2 Bmp4 Lhx1 Pax8 Sall1 Wfdc2 Dis3l2 Slc2a4 Lefty1 Nodal Acvr1c Dand5 Acvr1b Acvr2b Rasa1 Cer1 Zic3 Sall4 Epha1 Pou5f1 Gpc1 Ncan Tfdp2 Tfdp1 Ccnd3 Ccnd1 Cdk4 Cdk2 E2f1 Cdkn1a Agrn Clasp1 Clasp2 Lin28a Prdm14 Zscan10 Ss18 Mlph Dpf1 Dpf2 Rab27a Dpf3 Mlana Ss18l1 Pmel Bcl7a Ebf1 Bcl7b Egr2 Bcl7c Thrap3 Irf4 Zfp638 Myrip Fam120b Sytl2 Zfp467 Lep Rps27 Sox17 Mixl1 Eomes T Gsc Gata6 Lgi2 Lgi3 Efna1 Lgi4 Efna2 Lgi1 Efna3 Adam23 Mmp2 Adam11 Epha3 Adam22 Epha4 Epha5 Epha6 Epha7 Epha8 Ephb1 Ephb3 Ephb4 Ephb6 Efnb1 Efnb2 Efnb3 Efna4 Efna5 Robo1 Srgap1 Srgap2 Mag Srgap3 Arhgap39 Slit2 Nab1 Nab2 Prl Cdon Ucp1 Hnrnpu Elovl3 Mta1 Dsp Cidea Mta3 Prdm16 Ebf2 Pkp1 Dsg2 Bmp7 Dsg3 Zfp423 Dsg1a Polr2c Gmpr Polr2d Polr2a Hif3a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Adipoq Cdh2 Pxn Birc7 Prkca Asah1 Pxdn Edil3 H2ac20 Zeb1 Tert Gxylt2 Tbx2 Bcl2a1d Myc Akt3 Cacna1c Akt2 Akt1 Tcf7l1 Tcf7l2 Lyn Mov10 Yes1 H2ac12 Zic2 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 Ezh2 H2ax Csnk2a2 Tead4 Suz12 Ash2l Rac1 Hist1h2bp Fos H2aj Pik3r1 Pik3r2 Yap1 Unc5b Unc5a Pak1 Pak3 Pak2 H2bc9 H2bc7 H2bc8 H2bc3 Tead2 Tead1 Stat3 Mettl23 Aicda H2ab2 Kdm5a Kdm6a Stpg4 Uhrf1 Fes Tet3 H2bu2 Stt3b Srpk1 Tcf7 Pik3cb Pik3cd Pik3ca Wwtr1 Kmt2c Hist2h2aa1 Ywhag Epas1 Dpy30 Wdr5 Csnk2b Eed Gsk3b Lef1 H2bc14 Rhoa Ptpn11 Fyn H2bc21 Tnrc6c Rps6ka5 H2bc26 Pagr1a Rbbp5 Hoxc4 Rbbp4 Ctcf Rbbp7 Hoxd1 Tnrc6a Pias2 Tnrc6b Hoxb3 Hoxb1 Hoxb2 Hoxa3 Hoxa1 Ajuba Hoxa4 Pknox1 Mafb Zfp335 Meis1 Hoxd3 Hoxd4 Epha2 Itsn1 Ncbp2 Cacna1g Ncbp1 Myl12b Itgb1 Cacna1h Kalrn Myh11 Cacna1i Eloc Dock1 Myl6 Pak4 Arhgap35 Trio Plin1 Sema5a Fabp4 Actb Amh Nog Itgav Ptk2 Nell2 Msi1 Cxcr4 Dag1 Lfng Isl1 Upf3a Pfn1 Gspt2 Gspt1 Pfn2 Vasp Cxcl12 Trp53 Abl2 Lhx2 Lhx3 Shank3 Cul2 Lhx9 Lhx4 Nrp1 Pabpc1 Flrt3 Slit1 Slit3 Nck2 Akap5 Nck1 Cap1 Dcc Upf2 Usp33 Zswim8 Evl Etf1 Sos2 Robo2 Hoxa2 Ntn1 Pak6 Myo9b Pak5 Cap2 Prkar2a Il4ra Rps14 Rpl4 Rps16 Rps18 Rps19 Rpsa Rpl37 Rpl39 St8sia4 Rps10 Rps11 Rpl7 Hsp90aa1 Rpl32 Rps9 Rps7 Rps5 Rpl24 Rpl26 Rpl22 Rpl23 Batf Tgfb1 Rps25 Rps26 St8sia2 Rps21 Rpl39l Rps15a Clta Cltc Rps27l Rplp2 Rpl22l1 Rplp1 Rpl13a Rpl18a Rpl17 Rpl18 Rpl19 Rpl10l Rpl11 Cltb Rps3 Rps4x Pabpn1 Prm2 Npm2 H1.8 Cbfb Dnm2 Hspa8 Hes7 Noto Tbpl2 Pax7 Dll3 Mesp2 Tpst2 Msgn1 Msx1 Irs2 Fgf2 Rnps1 Fgf4 Fgf10 Fgf7 Fgf9 Gab2 Magoh Rbm8a Upf3b Itga1 Itga2 Gfi1 Cebpe Cebpa Csf3r Fli1 Klf5 Il6ra Eif4a3 Casc3 Magohb Sox2 Zeb2 Sox1 Fgf8 Znf521 Gbx2 Otx2 Tbx6 Pou3f1 Dicer1 Trpc6 Trpc5 Trpc7 Siah2 Trpc1 Trpc4 Trpc3 Trpm1 Fn1 Lama5 Vtn Lamb2 Lama1 Lamc3 Lamb3 Lama2 Lama3 Lama4 Lamc1 Lamb1 Krt1 Lamc2 Pip5k1c Prkcq Ednrb Lars1 Tfeb Mitf Eef1e1 Mark3 Ywhah Kars1 Hdac1 Tfec Zic1 Sox9 Edn1 Edn3 Tfe3 Pax3 Tnfsf11 Foxd3 Mc1r Rps6ka1 Mars1 Kit Mc5r Agap2 Csf1 Ywhaz Crmp1 Dars1 Dscaml1 Adgrg6 Hint1 Rap1gap Qars1 Utrn Rars1 Tyrobp Mc4r Pomc Mbp Ptprc Id1 Alx3 Ptpra Pou3f2 Ntn4 Sox10 Unc5d Aimp2 Trem2 Aimp1 Unc5c Sema7a Eprs1 Snai2 Rgmb Med9 Iars1 Rgma Tbx3 Artn Prx Mc3r Gfra2 Gfra3 Cdk19 Gfra4 Siah1a Med13l Drp2 Dpysl3 Dpysl4 Dpysl5 Cd72 Plxnb3 Cacna1s Mpz Plxna3 Plxna2 Dok1 Vav3 Dok2 Dscam Dok4 Dok5 Dok6 Prnp Pspn Plxnc1 Vav2 Nrtn Sema6d Sema6a Hjv Sema4a Ablim1 Ablim2 Ablim3 Pmp22 Sema3a Adgrv1 Hmgcr Sema3e Actg1 Hsp90ab1 Rock2 Rock1 Mcm5 Mcm2 Furin Pcsk6 Med22 Med21 Med28 Med29 Med11 Med19 Med18 Eif4g1 Git1 Eif4b Eif4e Tbx21 Stx1b Stx1a Cebpd Slc2a2 Psen1 Psen2 Ncstn Aph1b Cyp51a1 Srebf2 Dlg1 Dlg3 Mmp9 Dlg4 Arpc1b Actr2 Arpc1a Actr3 Sdcbp Myo5a Arpc3 Arpc2 Arpc5 Arpc4 Reln Vldlr Dab1 Satb1 Wasl Myo10 Cd36 Lig1 Mecom Prkaca Cacng8 Cacng4 Cacng2 Cacng3 Krtap3-1 Krt4 Krt2 Mapk7 Krtap3-2 Krt8 Myog Ets1 Krt7 Myod1 Krt5 Ntn3 Cdh4 Krtap16-3 Krtap12-1 Neo1 Ctnna2 Krt6a Krt9 Bnip2 Krt71 Spag9 Cdkn2a Krt78 Cdh15 Krt79 Myf6 Hira Krt76 Tcf4 Krt77 Myf5 Krt75 Krt72 Krt73 Krtap24-1 Krtap4-25 Kdm6b Krtap4-23 Krtap4-7 Krt40 Krt33b Ring1 Krt33a Cbx8 Phc2 Krtap4-2 Cbx6 Krtap17-1 Phc1 Krtap13-1 Krtap20-1 Cbx4 Krtap4-16 Krt27 Cbx2 Krt25 Krt26 Krt23 Rps6ka6 Phc3 Krt24 Krt20 Krtap9-5 Krtap1-3 Krt39 Krtap13-20 Krtap1-4 Krt34 Krt35 Krt32 Krt31 Krtap26-1 Krt82 Bmi1 Krt80 Krt87 Krt85 Rps6ka3 Krt86 Krt84 Wt1 Rps6ka2 Krt18 Krt16 Farp2 Krt17 Cebpb Map2k6 Krtap2-4 Krt14 Neurog3 Rnf2 Krt15 Onecut3 Nkx2-2 Krtap19-4 Nkx6-1 Krtap15-1 Krt12 Onecut1 Krt13 Insm1 Mafa Krt10 Tiam1 Ptf1a Pdx1 Gab1 Pax6 Plcg1 Neurod1 Foxa2 Foxa3 Rfx6 Hnf1a Hnf1b Grin2b Egf Bcl2 Areg Jag1 Adam10 Dll1 Mef2a Klk13 Smyd1 Mesp1 Tbx1 Tbx20 Hand1 Myocd Tut7 Tut4 Paip1 Grin1 Myh9 Myl12a Erbb2 Myb Med8 Med4 Med6 Gata3 Gata4 Gata2 Pou2f2 Gatad2a Gatad2b Ret Rarb Tal1 Tcf12 Kat2b Rarg Kat2a Men1 Cnot11 Itga5 Tfap2c Tfap2a Tfap2b Cnot10 Abl1 Cdk8 Sin3a Tnks1bp1 Hand2 Cox7a1 Klf4 Ins2 Nkx2-5 Cnot6l Actl6a Cacna1d Smarce1 Havcr2 Stat5a Stat5b Acvr2a Pou2f1 Itga8 Foxa1 Ncoa3 Usf1 Spta1 Nrp2 Scn9a Scn5a Sptb L1cam Scn1a Scn1b Lypla2 Kcnq3 Kcnq2 Numb Shtn1 Gap43 Ank3 Chl1 Ank1 Scn10a Scn2a Scn2b Dnm1 Kif4 Sptan1 Dnm3 Rps6ka4 Dcx Ranbp9 Ezr Scn7a Scn11a Scn3a Scn3b Ephb2 Itga9 Ifng Itga10 Dpysl2 Alcam Nfasc Scn8a Rdx Kdm5b Dmrt1 Zfpm2 Ncam1 Ptgds Msn Itga2b Nrcam Scn4a Sptbn1 Scn4b Sptbn2 Cntn2 Cntn1 Cntnap1 Cntn6 Hes1 Sptbn4 Dek Trim33 Spi1 Maml1 Maml2 Hdac11 Hdac10 Rbpj Klf13 Med23 Med24 Med25 Cacnb3 Med20 Cacnb4 Cacnb1 Hey2 Cacnb2 Hey1 Med26 Med27 Med12 Med13 Med14 Med10 Med15 Med16 Med17 Ncor2 Pcgf2 Mbd3 Yy1 Drap1 Mamld1 Foxh1 Arid1a Arid1b Egfr Maf Dct Serpine1 Tyrp1 Tyr Dlx5 Cnot3 Cnot2 Cnot1 Cnot7 Cnot6 Med30 Med31 Cnot4 Cnot9 Cnot8 Kmt2d Tnf Hdac2 Hdac5 Smarcb1 Eif4a2 Eif4a1 Hdac7 Hdac6 Hdac9 Hdac8 Lefty2 Smarca2 Smarca4 Srf Smarcd1 Smarcd2 Tbx5 Smarcc2 Smarcc1 Btg4 Zfp36l2 Pabpn1l Ccnc Cfl1 Pck1 Grb10 Stat6 Hnf4a Hnf4g Psma4 Foxo4 Psma3 Psma6 Foxo1 Psma5 Psma2 Tgfa Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Nfkb1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Runx3 Psmb3 Psmb2 Rela Grb7 Psma7 Psmc6 Psmc5 Ppargc1b Psmc2 Rnd1 Psmc1 St14 Gck Psmc4 Cdsn Loricrin Psmc3 Klk5 Ubc Kazn Psmd7 Sprr1b Psmd6 Klk8 Ppl Tgm1 Plxna1 Lce1m Psmd8 Psmd3 Tgm5 Plxna4 Psmd2 Casp14 Lce3b Psmd1 Pkp4 Tchh Prss8 Adrm1 Sem1 Evpl Cela2a Spink5 Perp Csta2 Sprr2k Pkp2 Klk12 Pkp3 Dsg4 Lipk Smad1 Dsc1 Smad2 Klk14 Nr2f2 Rptn Smad3 Ppara Dsc2 Smad4 Lipn Pparg Dsc3 Tcf3 Rxra Hdac4 Ldb1 Ube2i Rara Nr5a1 Kat5 Chd3 Chd4 Notch2 Rhob Arhgef11 Diaph1 Mta2 Arhgef28 Jup Brca1 Itgb3 Rhoc Plxnb1 Tln1 Plk1 Ngef Arhgef7 Src Sh3kbp1 Atp6v0b Ctnnb1 Myh14 Myh10 Sema4d Rras Cdh1 Limk1 Limk2 Sh3gl2 Met Atp6v1c1 Shc3 Shc1 Mapk1 Mapk3 Ywhab Mapk12 Gpr143 Atp6v1e1 Mapk14 Frs2 Atp6v1a Atp6v1b2 Map2k2 Atp6v0d1 Nras Atp6v0e1 Map2k1 Atp6v1g1 Sos1 Hras Mapk11 Atp6v1h Ncor1 Helz2 Carm1 Paxip1 Ep300 Tbl1x Mef2d Hdac3 Ncoa2 Ncoa1 Xpo1 Tbl1xr1 Smarcd3 Eya1 Ncoa6 Med1 Ctnna1 Ppargc1a Stat4 Col6a1 Snai1 Col4a3 Crebbp Mef2c Foxf1 Col6a2 Chd9 Sirt1 Col4a4 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 96%190704 Oligomerization of connexins into connexons Gja1 Gjb2 Gjb1 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs Myl6 Pak1 Rock2 Rock1 Myh14 Rhob Myh10 Myh9 Rhoc Limk1 Limk2 Rhoa Myl12a Ppp1r12b Ppp1r12a Myl12b Myh11 Ppp1cb Cfl1 FORMATION OF PARAXIAL MESODERM%REACTOME DATABASE ID RELEASE 96%9793380 Formation of paraxial mesoderm Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Nog Mamld1 Ctnnb1 Notch1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Kat2b Psmd7 Psmd6 Kat2a Psmd8 Psmd3 Psmd2 Hes7 Psmd1 Adrm1 Sem1 Lfng Dll3 Mesp2 Msgn1 Lef1 Fgfr1 Wnt3a Ep300 T Dll1 Bmp4 Tbx6 Maml1 Maml2 Rbpj Epha4 Crebbp NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription Tle4 Hey2 Tle2 Hey1 Tle1 Hdac2 Hdac1 Hdac5 Hdac4 Myc Ncor2 Hdac7 Hdac6 Hdac9 Ncor1 Hdac8 Hes1 Skp1 Hif1a Ep300 Cdk8 Tbl1x Mamld1 Hdac3 Notch1 Rbx1 Tbl1xr1 Ubc Kat2b Maml1 Maml2 Heyl Hdac11 Kat2a Hdac10 Hes5 Rbpj Ccnc Crebbp Cul1 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle Ganab Sel1l Mogs Edem2 Rnf5 Syvn1 Mlec Man1b1 Engase Edem1 Calr Prkcsh Rnf185 Rad23b Derl2 Derl1 Canx Vcp Psmc1 Ngly1 Ubc Ubxn1 Rnf103 Amfr Rnf139 Marchf6 Trim13 Uggt1 Pdia3 Uggt2 Edem3 Os9 HIV TRANSCRIPTION ELONGATION%REACTOME%R-HSA-167169.4 HIV Transcription Elongation Gtf2h3 Supt5h Gtf2h5 Ercc2 Ccnh Ercc3 Cdk7 Ell Nelfa Nelfb Nelfe Ctdp1 Polr2c Polr2d Ncbp2 Polr2a Ncbp1 Polr2b Supt4h1a Polr2g Tcea1 Polr2h Nelfcd Polr2e Supt16 Polr2f Cdk9 Polr2k Mnat1 Ssrp1 Polr2i Ccnt1 Polr2j Gtf2h2 Eloa Gtf2h1 Gtf2f2 Gtf2h4 Eloc Gtf2f1 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes Brca1 Atm Jun Cdk13 Cdk12 Fanci Fancc Msh2 Pms2 Mlh1 Polr2c Polr2d Polr2a Polr2b Fancd2 Polr2g Polr2h Polr2e Polr2f Polr2k Mnat1 Polr2i Polr2j Gtf2h2 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Supt5h Gtf2h5 Trp53 Ercc2 Ccnh Ercc3 Cdk7 Atf2 Ell Nelfa Nelfb Nelfe Mdc1 Ctdp1 Ccnk Rad51d Chek1 Supt4h1a Tcea1 Nelfcd Fos Supt16 Cdk9 Ccnt2 Ssrp1 Ccnt1 Eloa Eloc Ddb2 CELLULAR HEXOSE TRANSPORT%REACTOME DATABASE ID RELEASE 96%189200 Cellular hexose transport Slc5a4a Slc2a10 Slc2a12 Slc50a1 Slc2a2 Slc5a1 Slc2a3 Slc45a3 Slc2a4 Slc5a10 Slc2a9 Slc2a8 Slc5a9 Slc2a6 Slc2a7 Fgf21 Slc2a1 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 96%5688849 Defective CSF2RB causes SMDP5 Sftpb Csf2rb2 Sftpd Csf2ra Sftpc Sftpa1 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex Rps5 Eif3m Eif3i Eif3l Eif3k Eif3f Eif3e Rps25 Eif3h Rps26 Eif3g Eif3b Eif3a Rps21 Eif3d Eif3c Eif3j2 Rps15a Eif1ax Eif2s3x Eif2s2 Eif2s1 Rps27l Rps27 Rps3 Rps4x Rps14 Rps16 Rps18 Rps19 Rpsa Rps10 Rps11 Rps9 Rps7 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 96%168927 TICAM1, RIP1-mediated IKK complex recruitment Ube2v1 Ripk3 Ikbkb Ripk1 Ube2d3 Birc3 Ubc Birc2 Ikbkg Ticam1 Tlr3 Ube2d1 Traf6 Ube2n Chuk OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 96%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Vhl Cul2 Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Hif1a Ube2d1 Psmb5 Psmb4 Psmb7 Ajuba Psmb6 Psmb1 Psmb3 Psmb2 Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Egln2 Psmc3 Egln3 Ube2d3 Ubc Wtip Limd1 Psmd7 Hif3a Psmd6 Psmd8 Psmd3 Psmd2 Psmd1 Adrm1 Epas1 Sem1 Eloc ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139915 Activation of PUMA and translocation to mitochondria Ppp1r13b E2f1 Trp73 Trp53 Trp63 Tfdp2 Tfdp1 Trp53bp2 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 96%9025094 Biosynthesis of DPAn-3 SPMs Alox12 Alox5 Ptgs2 Alox15 DASATINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669914 Dasatinib-resistant KIT mutants Kit LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 96%9620244 Long-term potentiation Actn2 Nefl Src Gria2 Grin1 Dlg1 Grin2d Dlg3 Grin2c Nrg1 Dlg4 Camk2g Camk2d Gria1 Grin2b Camk2b Camk2a Nrgn Grin2a Dlg2 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 96%5579029 Metabolic disorders of biological oxidation enzymes Tpmt Slc35d1 Ugt1a5 Ugt1a1 Fdx1 Cyp2r1 Fdxr Fdx2 Ggt1 Cyp19a1 Cyp2u1 Maoa Cyp1b1 Acy1 Cyp21a1 Tbxas1 Cyp11b2 Oplah Cyp26b1 Cyp26c1 Cyp11b1 Cyp27b1 Ahcy Gclc Cyp11a1 Gclm Gss Cyp17a1 Cyp4f39 Cyp27a1 Cyp24a1 Mat1a Cyp7b1 Fmo3 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates Cyp2u1 Cyp2w1 Cyp4a32 Cyp2s1 Cyp4f15 Cyp2d22 Cyp4f39 Cyp3a57 Cyp4a12b Cyp4f3 Cyp4f40 Cyp4b1 ASP-3026-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717264 ASP-3026-resistant ALK mutants Alk SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer Fgfr3 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 96%8875513 MET interacts with TNS proteins Itgb1 Tns4 Tns3 Hgf Met ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 96%451326 Activation of kainate receptors upon glutamate binding Plcb3 Dlg1 Plcb2 Dlg3 Plcb1 Grik5 Gng10 Dlg4 Grik2 Grik1 Grik4 Grik3 Ncald Gng3 Gng2 Gng4 Gng7 Gng8 Gngt1 Gngt2 Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9607240 FLT3 Signaling Socs6 Abl2 Grb10 Lck Nras Sos1 Stat5a Grap2 Stat5b Hras Ptpn11 Gab2 Fyn Csk Akt3 Akt2 Akt1 Bcl2l11 Sh2b3 Foxo3 Flt3l Socs2 Sla Ptprj Cbl Ubc Pik3ca Sla2 Syk Cdkn1b Flt3 Hck Pik3r1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 96%111996 Ca-dependent events Prkaca Prkar2b Camkk1 Camkk2 Prkca Prkcg Prkx Prkar1a Prkacb Camk4 Prkar2a Pla2g4a Grk2 Pde1b Pde1c Prkcd Adcy3 Pde1a Adcy4 Adcy1 Adcy2 Adcy7 Camk2g Adcy8 Adcy5 Camk2d Adcy6 Camk2b Adcy9 Camk2a Mapk1 Prkar1b IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855229 IP6 and IP7 transport between cytosol and nucleus Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Pom121 Nup205 Nup133 Nup188 Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Nup210 Nup155 Nup153 Nup85 Nup37 Sec13 Nup160 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 96%69183 Processive synthesis on the lagging strand Pcna Rpa2 Prim2 Prim1 Pola2 Pold4 Pola1 Pold3 Rpa3 Dna2 Lig1 Fen1 Pold2 Pold1 Rpa1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72172 mRNA Splicing Lsm5 Dnajc8 Rbm22 Lsm6 Lsm7 Rbm17 Ddx46 Ddx42 Sap18b Ddx23 Ddx5 Ybx1 Mtrex Prpf40a Snrnp70 Htatsf1 Rbm7 Ppp1r8 Snrpa Snrpc Rbm25 Srsf10 Tcerg1 Rbm39 Hspa8 Rnps1 Srsf1 Srsf9 Cdc40 Srsf7 Srsf6 Srsf3 Magoh Ddx39b Srsf2 Srsf11 Srrm1 Rbm8a Upf3b Slu7 Acin1 Alyref Dhx38 U2af1l4 Eif4a3 Snrpb Casc3 Magohb Snrpd2 Snrpd1 Snrpd3 Ddx41 Dhx9 Ppil2 Hnrnpu Znf830 Polr2c Polr2d Polr2a Polr2b Polr2g Polr2h Polr2e Polr2f Polr2k Polr2i Polr2j Gtf2f2 Gtf2f1 Prpf4 Leng1 Prpf3 Fam50a Prpf31 Zmat2 Cactin Pnn Rnf113a2 Sf1 Rbmx2 Nsrp1 Tfip11 Prpf18 Ik Dhx8 Wdr70 Snip1 Fam32a Steep1 Dhx35 Yju2 Smu1 Lsm8 Gpatch1 Ppwd1 Snrnp27 Gcfc2 Ccdc12 Ubl5 Syf2 Phf5a Prpf4b Sde2 Usp39 Crnkl1 Sart1 Wbp4 Cwf19l2 Mfap1b Prpf38a Prkrip1 Nkap Rbm42 Luc7l3 Bud13 Xab2 Hnrnpa2b1 Zcrb1 Prpf19 Puf60 Bcas2 Gpkow Smndc1 Aqr Pcbp2 Pcbp1 Hnrnpr Snrnp25 Zmat5 Sugp1 Snrnp48 Hnrnpd Snrnp35 Zrsr2 Hnrnpf Rnpc3 Hnrnpk Ccar1 Pdcd7 Hnrnpl Hnrnpm Rbmx Hnrnph2 Hnrnph1 Tra2b Cwc22 Cwc27 Hnrnpc Cwc25 Cwc15 Rbm5 Txnl4a Snrnp200 U2surp Snrpb2 Snrpa1 Ptbp1 Sf3a1 Sf3a2 Sf3a3 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Sf3b5 Sf3b6 Ctnnbl1 Srrt Snrnp40 Eftud2 Snrpn Cherp Fus Isy1 Cdc5l Plrg1 Hnrnpa3 Ppil4 Ppil3 Hnrnpa1 Ppil1 Prcc Rbm10 Dhx16 Dhx15 Srrm2 Ncbp2 Ncbp1 Prpf6 Ppig Ppih Ppie Prpf8 Wbp11 Lsm2 Lsm3 Lsm4 Pqbp1 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome Src Pxn Gab1 Egfr Ptpn11 Pik3ca Egf Tgfa Csk Ereg Areg Hbegf Btc Epgn Pik3r1 Pag1 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 96%9603505 NTRK3 as a dependence receptor Nelfb Ntrk3 Bax DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME%R-HSA-9927432.2 Developmental Lineage of Mammary Gland Myoepithelial Cells Egf Tgfa Areg G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta Plcb3 Gngt1 Gngt2 Plcb2 Plcb1 Gng10 Gng3 Gng2 Gnb2 Gnb1 Gng4 Gnb4 Gnb3 Gng7 Gnb5 Gng11 Gng8 Gng12 Gng13 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME DATABASE ID RELEASE 96%9970672 FXIIa activates plasma kallikrein-kinin system Plaur H2bc14 H2bc9 H2bc7 H2ac20 Kng2 H2bc8 H2bc3 H2bc21 H2bc26 F12 Klkb1 H2ab2 Krt1 Prcp H2bu2 H2ac12 H2ac11 Hrg C1qbp H2ac15 Serping1 H3c7 H2az1 H2ax Hist1h2bp Hist2h2aa1 A2m SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 96%3065676 SUMO is conjugated to E1 (UBA2:SAE1) Sumo3 Uba2 Sae1 IRAK4 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5603041.4 IRAK4 deficiency (TLR2 4) Tlr4 Fgb Fga Fgg Irak4 S100a1 Cd36 S100a9 Myd88 Tirap S100a8 Tlr1 Cd14 Btk Tlr6 Tlr2 Ly96 SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants Mapk1 Map2k2 Mapk3 Map2k1 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 96%5688890 Defective CSF2RA causes SMDP4 Sftpb Csf2rb2 Sftpd Csf2ra Sftpc Sftpa1 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection Cd3g Elmo2 Vav2 Cyfip1 Wipf3 Arpc1b Actr2 Arpc1a Actr3 Wipf2 Wipf1 Btk Actg1 Actb Myo5a Arpc3 Arpc2 Cyfip2 Arpc5 Arpc4 Mapk1 Fcgr4 Syk Ptk2 Mapk3 Fgr Myh2 Brk1 Myo1c Nckipsd Was Wasf3 Baiap2 Nckap1l Wasl Myo10 Crk Nckap1 Nck1 Fyn Wasf2 Wasf1 Abl1 Abi2 Myo9b Abi1 Lyn Yes1 Myh9 Rac1 Vav1 Elmo1 Hck Vav3 Dock1 CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.3 CRMPs in Sema3A signaling Gsk3b Nrp1 Dpysl2 Sema3a Fyn Dpysl3 Cdk5r1 Plxna1 Dpysl4 Dpysl5 Plxna4 Cdk5 Plxna3 Plxna2 Fes Crmp1 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F2 Ggcx Pros1 Furin Gas6 Proz F7 F9 F10 Proc DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 96%3595172 Defective CHST3 causes SEDCJD Chst3 Ncan Bgn Cspg5 Cspg4 Dcn Bcan Vcan SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME DATABASE ID RELEASE 96%9725370 Signaling by ALK fusions and activated point mutants Mapk9 Mapk8 Tyk2 Stat5a Wdcp Jun Vcl Fn1 Grb2 Stat3 Junb Cltc Stat1 Atic Sqstm1 Skp1 Tfg Gzmb Sec31a Npm1 Rbx1 Lmo7 Rb1 Pik3cb Zap70 Mdm2 Rrbp1 Ubc Pik3ca Gcc2 Mapk1 Cdkn1a Mapk3 Kif5b Ppfibp1 Cul1 Cebpb Frs2 Irs1 Trp53 Ranbp2 Il10ra Plcg1 Frs3 Ptpn6 Irf4 Hdac1 Prf1 Foxm1 Bcl2a1d Msn Zc3hc1 Hip1 Icos Tpr Alk Tnrc6c Eml4 Bcl11a Ppm1b Eef1g Cars1 Prkar1a Eif2ak3 Dctn1 Strn Birc6 Mov10 Ago4 Ago3 Ago2 Ago1 Klc1 Il10 Mcl1 Dnmt1 Rnf213 Twist1 Myh9 Il22b Pik3r1 Pik3r2 Tpm3 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 96%9665247 Resistance of ERBB2 KD mutants to osimertinib Erbb2 Cdc37 Erbin Hsp90aa1 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 96%168142 Toll Like Receptor 10 (TLR10) Cascade Mapk9 Mapk7 Mapk8 App Ikbkb Jun Peli1 Elk1 Ikbkg Map3k7 Traf2 Map3k8 Nfkb1 Skp1 Fbxw11 Rela Btrc Casp8 Ubc Mapk1 Nfkbib Mapk3 Rps6ka3 Irak1 Nfkbia Mapkapk3 Rps6ka2 Traf6 Mapkapk2 Cul1 Ube2n Map2k7 Mapk14 Chuk Map2k6 Ppp2cb Ppp2ca Ube2v1 Trp53 Map2k4 Tab3 Map2k3 Tab2 Tab1 Mapk10 Map2k1 Mapk11 Ripk2 Myd88 Rps6ka5 Nkiras1 Atf2 Nkiras2 Rps6ka1 Lrrc14 Ecsit Vrk3 Ikbip Map3k1 Ppp2r1b Peli2 Ppp2r1a Peli3 Tlr5 Tnip2 Saa3 Nod2 Nod1 S100b Dusp3 Dusp4 Irak4 N4bp1 Dusp7 Tifa Dusp6 Alpk1 Irak2 Ager Nlrx1 Nfkb2 Mef2a Usp14 Usp18 Fos Ppp2r5d Mef2c DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610780 Degradation of GLI1 by the proteasome Prkaca Psma4 Psma3 Psma6 Psma5 Psma2 Psma1 Psmd12 Psmd11 Psmd14 Psmd13 Skp1 Psmb5 Prkacb Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmb2 Itch Btrc Rbx1 Psma7 Psmc6 Psmc5 Psmc2 Psmc1 Psmc4 Psmc3 Ubc Psmd7 Gli1 Psmd6 Numb Psmd8 Psmd3 Psmd2 Sufu Psmd1 Adrm1 Sem1 Cul1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 96%975576 N-glycan antennae elongation in the medial trans-Golgi Mgat3 Mgat5 B4galt6 Man2a1 Lhb Chst10 Mgat2 B4galt1 B4galt2 B4galt3 Fut8 St8sia2 St8sia3 St3gal4 Mgat4c Mgat4a Mgat4b Fuca1 St8sia6 St6gal1 Chst8 Cga B4galt4 B4galt5 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript Nup43 Ranbp2 Nup93 Nup50 Nup35 Nup54 Cpsf4 Pom121 Nup205 Nup133 Nup188 Eif4e Tpr Nup107 Rae1 Ndc1 Nup42 Nup62 Nup88 Aaas Nup214 Sympk Nup210 Nup155 Nup153 Alyref Nxf1 Cpsf1 Cpsf2 Cpsf3 Wdr33 Fip1l1 Nup85 Ncbp2 Ncbp1 Nup37 Sec13 Nup160 SIGNALING BY WNT%REACTOME%R-HSA-195721.7 Signaling by WNT Nfatc1 Ppp3r1 Porcn Ppp3ca Ppp3cb Pip5k1b Ap2m1 Tle3 Xiap Dvl1 Dvl2 Dvl3 Ap2a2 Ap2a1 Rbx1 Snx3 Usp8 Ap2b1 Wnt5a Wnt9a Ap2s1 Wnt9b Wnt10a Wnt10b Pfn1 Wnt8b Wnt8a Wnt16 Wnt11 Gng10 Rnf146 Tnks2 Tnks Wnt6 Gng3 Gng2 Gng4 Wnt7b Gng7 Wnt3a Gng8 Wnt7a Wnt2 Wnt1 Wnt4 Wnt3 Fzd1 Gngt1 Gngt2 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Scrib Fzd8 Wnt2b Camk2a Gnb2 Gnb1 Gnb4 Gnb3 Gnb5 Gng11 Gng12 Gng13 Itpr3 Itpr2 Itpr1 Hecw1 Rspo3 Klhl12 Cul3 Prkcg Cdc73 Clta Cltc Leo1 Ruvbl1 H3c8 Cltb Amer1 Ppp2cb Ppp2ca Tle1 Kmt2b Sox17 Smarca4 Ppp2r1b Ppp2r1a Sox2 Wnt5b Ror1 Ror2 Ppp2r5d Ppp2r5c Ppp2r5b Ppp2r5a Ppp2r5e Psma4 Psma3 Psma6 Psma5 Vps35 Psma2 Vps29 Psma1 Wls Map3k7 Psmd12 Psmd11 Psmd14 Psmd13 Smurf2 Vps26a Skp1 Smurf1 Psmb5 Psmb4 Tmed5 Psmb7 Psmb6 Psmb1 Runx3 Psmb3 Psmb2 Prkcb Sox3 Btrc Vangl2 Trrap Psma7 Sox7 Psmc6 Sox6 Psmc5 Psmc2 Pygo2 Sox4 Psmc1 Psmc4 Pygo1 Dkk1 Psmc3 Dkk2 Ubc Dkk4 Psmd7 Rnf43 Sox13 Psmd6 Kremen2 Kremen1 Psmd8 Bcl9l Psmd3 Bcl9 Psmd2 Cby1 Psmd1 Znrf3 Csnk1g2 Sfrp2 Adrm1 Sfrp1 Sem1 Rspo1 Cul1 Rspo2 Rspo4 Chd8 Lrp6 Lrp5 Wif1 Ccdc88c Ryk Plcb3 Ctnnbip1 Plcb2 Lgr4 Plcb1 Sost Lgr5 Pde6g Prkca Lgr6 Gnao1 Frat2 Nlk Frat1 H2ac20 Gnat2 Prkg2 Tert Hdac1 Pde6a Pde6b Prkg1 Myc Sox9 Prickle1 Akt2 Akt1 Kat5 Tcf7l1 Tcf7l2 Ywhaz Mov10 H2ac12 H2ac11 Ago4 Ago3 Ago2 Ago1 H2ac15 H3c7 H2ax Axin2 Csnk2a2 Tle5 Daam1 Ash2l Rac1 Hist1h2bp Cav1 H2aj Arrb2 Axin1 H2bc9 H2bc7 H2bc8 H2bc3 Rac2 Zranb1 H2ab2 H2bu2 Ctnnb1 Tcf7 Hist2h2aa1 Ctbp1 Ctbp2 Dpy30 Wdr5 Men1 Csnk2b Rac3 Tle4 Tle2 Gsk3b Csnk1e Csnk1a1 Lef1 H2bc14 Pard6a Rhoa H2bc21 Tnrc6c H2bc26 Rbbp5 Tnrc6a Tnrc6b Ep300 Apc Xpo1 Crebbp