LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Agt Ace ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway Kdr THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Pdha1 Idh3g Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Ikbkb Cd40 Mapk14 Traf3 Traf6 Elp1 Ikbkg Nfkbia Map3k1 Cd40lg Dusp1 Nfkb1 Chuk Tnfaip3 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Vac14 Sacm1l Inpp1 Pik3cb Pik3r4 Plcb4 Itpka Miox Ptpmt1 Inpp4a Pi4ka Ipmk Pikfyve Impa1 Mtor Isyna1 Becn1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Agt Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Gys1 Gaa Agl Ugp2 Pygl Amy1 Pgm1 Ugdh Gpi Ugt3a2 Gusb Pgm2l1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 Cyp2c65 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Gls2 Glud1 L2hgdh Pcx D2hgdh Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Gusb Ugt8 Hk1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Mapk8 Nfkbia Shc1 Map3k1 Ptpn7 Cd3g Cd247 Nfkb1 Elk1 Map2k7 Cd3d Mapk3 Ubc Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Fos Rela Nfat5 Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Prkcb Plcg1 Prkca PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Nqo1 Nos3 Abcb1a Abcg2 Ralbp1 Por Abcc1 Abcc2 Slc22a16 Ndufs2 Ndufs7 Akr1a1 Xdh Cbr3 Cbr1 Akr1c18 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Amt Cps1 Glul Dld Gls2 Glud1 Hal Sds Gldc Aqp8 Asrgl1 Asns TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Map2k1 Itpr1 Raf1 Cacna1f Cacna1c Cacna1d Hras Mapk1 Cacna1s Nfkbia Nfkb1 Prkcb Mapk3 Prkca Rela Plcb1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Itpr1 Prkca Gnaq Plcb1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Synj1 Vac14 Inpp4b Pik3c2a Pten Pik3c3 Pik3r4 Egfr Pik3r1 Fig4 Cdipt Ambra1 Pik3cd Pip5k1a Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Erbb2 Plcb1 Becn1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Srm Odc1 Mat2b Mat2a ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Agt Ace MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Ldhd Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Gmds Pfkl Tpi1 Fbp1 Aldoa Gmppa Pmm1 Mpi Uxs1 Akr1b1 Sord Khk Pfkfb1 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Tyms Rrm2b Dck Cmpk1 Nme1 Dctd Nt5c Slc28a3 Slc29a1 Slc28a1 Ctps1 Rrm1 Rrm2 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Pdia2 Sdf2l1 Comt Hyou1 Cyp2e1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a5 Ugt1a1 Hspa5 Ephx1 Cyp3a16 Cyp2c50 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Nqo1 Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Hsd17b10 Acat1 Hadh Acadl Acads Acaa2 Echs1 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Cyp3a16 Cyp2d22 Sult1a1 Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Qars1 Rps15a Rps18 Rps19 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Aldh1a1 Cyp3a16 Cyp2b10 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Agt Ace DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Dct Tyr PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Gmds Pfkl Tpi1 Fbp1 Aldoa Gmppa Pmm1 Mpi Uxs1 Akr1b1 Sord Khk Pfkfb1 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway Cyp3a16 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Agt Ace INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Creb1 Gngt1 Fshr Prkacb Cga Gng12 Ppp1ca Gnb1 Adcy2 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Ddc Pnmt Th GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Acsm1 Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2b10 Ugt1a9 Slc22a1 Abcc2 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Per1 Npr1 Cry1 Clock Csnk1e CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Map2k1 Lyn Lck Cd79b Grb2 Orai1 Blnk Raf1 Hras Mapk8 Shc1 Map3k1 Elk1 Prkcb Mapk3 Plcg1 Rac1 Prkca Ppp3ca Jun Ppp3cb Syk Fos Nfat5 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Tub Gngt1 Chrm1 Htr2c Gnaq Gnb1 Plcb1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Eprs1 Rpl4 Rps16 Rps15a Rps18 Rps19 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Farsa Farsb Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Agt Ace GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Bpgm Pgam1 G6pc1 Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Cyp3a16 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Cyp2e1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a1 Hspa5 Abcb1a Sult1e1 Sult2a1 Abcg2 Abcc4 Abcc5 Abcc1 Ugt2b36 Gstt1 Cyp2d22 Sult1a1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Pccb Mmut Dbt Dld Bckdhb Sds Pcca Bckdha METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp3a16 Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Ugt1a9 Cbr1 Cyp2d22 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Aars1 Rps16 Rps15a Rps18 Rps19 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Sdhd Sdhc Sdhb Sdha Ndufa1 ATP6 mt-Co1 Uqcrc1 Atp5f1d Atp5f1c Atp5pb Atp5f1b Atp5f1a Gpd2 Slc25a4 Slc37a4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Vkorc1 Nqo1 Ggcx LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Cyp3a16 Cyp1a2 Scn1b 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Btd Hlcs Acacb Spcs1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Agt Ace OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Gaa Ugp2 B4galt1 G6pc1 Pgm1 Gale Glb1 Lct Gla Akr1b1 Hk1 Galt FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Cyp3a16 Aldh3a1 Cyp2e1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpk1 Inpp4b Nudt3 Minpp1 Itpka Inpp4a Ipmk Ippk Impa1 Bpnt1 Ip6k1 Isyna1 Inpp5j BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Acat1 Hadh Acads Echs1 Acsm1 Hmgcl Oxct1 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Fdps Hmgcr Acat1 Idi1 Mvd Mvk Fdft1 Lss Sqle Pmvk BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Gpi Pkm Pfkp Tpi1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Pgs1 Gpam Gpd1 Crls1 Cdipt Cds1 Pla2g2d Ptdss1 Ptdss2 Gde1 Plpp1 Pisd Phospho1 Pld2 Pcyt1a Pla2g15 Lypla1 Ptpmt1 Chat Dgka Pemt Chka Agpat1 Gpd2 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C9 Cfp C8a Cfb Cfd C3 C5 C6 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Slc6a4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Sptlc1 Acer2 Cerk Sptlc2 Enpp1 Degs2 Gba1 B4galt2 Ugt8 Sphk2 Ugcg Sdr16c5 Gla HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Cat Sod3 Sod2 Tyrp1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Cyp3a16 Abcb1a Abcg2 Pdia2 Sdf2l1 Abcc1 Abcc2 Hyou1 Pdia6 Pdia4 Ppib Bche Dnajb11 Ces2h Ces1d Ugt1a9 Top1 Erp29 Ugt1a1 Hspa5 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Agt Ace WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Ireb2 Gsr Glud1 Pkm Sdhd Sdhc Hk1 Sdhb Sdha Cs EG433182 Idh3g Mdh1 Pgd Mpc1 Fh Idh1 Idh3a Slc2a13 Cad Gapdhs Bpgm Aco1 Rpia Gpi H6pd Tktl1 Taldo1 Pfkm Bckdhb Pdhx Aldoc Gls Acly Ogdh Pgk2 Sucla2 Slc16a1 PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway Cyp3a16 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Tubb1 Cdkn1a Abcc10 Cyp3a16 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Map2k1 Socs1 Irs1 Grb2 Insr Ptpn6 Raf1 Ghr Stat5a Stat5b Hras Mapk1 Rps6ka1 Slc2a4 Ins2 Sos1 Jak2 Shc1 Mapk3 Plcg1 Prkca KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Slc14a2 Atp1a2 Atp1a1 Atp1a3 Aqp3 Aqp2 Atp6v1b1 Ca1 Slc4a1 Scnn1a Scnn1b Scnn1g Atp1b1 Atp1b3 Atp1b2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd1 Gpd2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Vac14 Pik3c3 Pik3r4 Ptpmt1 Pik3cd Prex1 Inpp5f Plce1 Inppl1 Zfyve16 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Vars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Mapk8 Map3k1 Jun Faf1 Arhgdib Map3k7 Pak1 Prkdc Ripk2 Fasl Parp1 Cflar Pak2 Lmnb1 Ptpn13 Lmnb2 Casp8 Rb1 Casp7 Casp3 Casp6 Sptan1 Lmna Map2k4 Fas Fadd Daxx Dffa Dffb ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Tubb1 Slco1b2 Abcb1a Abcg2 Abcc1 Tuba1b Abcc2 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Agxt Gpt Mpc1 Pcx Aars2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Rpe Rpia Tpi1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Adam17 Prkca Erbb4 Erbb3 Psen1 Nrg2 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Agt Ace FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Alox15 Ugt1a2 Cyp4f17 Cyp4f15 Slc22a8 Ptgds Cyp3a16 Cyp2j6 Cyp4f3 Cyp2c50 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Pdia2 Ptgis Sdf2l1 Cyp2c65 Hyou1 Cyp2e1 Pdia6 Ephx2 Pdia4 Ptgs1 Ppib Alox12b Slc22a6 Dnajb11 Ptgs2 Ugt1a9 Erp29 Cbr1 Ugt1a1 Hspa5 Ugt2b1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Aqp1 Slc7a8 Slc7a9 Slc4a4 Slc6a20a Slc9a1 Ca1 Slc22a2 Slc22a6 Slc1a1 Slc3a1 Slc38a4 Slc3a2 Slc7a6 Slc7a7 Slc7a5 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Map2k1 Grb2 Ptpn6 Raf1 Epo Epor Stat5a Hras Sos1 Jak2 Mapk8 Shc1 Elk1 Mapk3 Plcg1 Jun Fos CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Cyp3a16 Oprm1 Cyp2d22 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Rpe Rpia Pgm1 Dera Prps1 Gpi Pgls Pfkl G6pdx Tkt Fbp1 Aldob HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Rapgef4 Glp1r Camkk1 Itpr3 Abcc8 Cacna2d2 Cacna1a Slc2a2 Chrm3 Cacnb1 Prkca Gng2 Adcy10 Gnaq Vamp2 Gnb1 Plcb1 Rab3a LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Creb1 Htr6 Gngt1 Prkacb Ppp1ca Gnb1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Cyp3a13 Cyp3a16 Oprm1 Cyp2d22 Grin2a Cyp2c50 Cyp2b10 Grin1 Cyp2c65 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Ahcy Cbs Cth Mettl6 Mars1 Scly Sephs2 Ggt1 Mat2b Slc39a8 Papss1 Mat2a GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Gngt1 Prkacb Gnb1 Adcy2 Ptgdr DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gys1 Ganab Hkdc1 Pgm2 Gpi Gbe1 Hk1 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Itpr1 Akt1 Adcy1 Rock1 Lpar4 Srf Gng2 Gnb1 Plcb1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Ntpcr Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Hsd17b1 Cyp19a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 Asns CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Map2k1 Itpr1 Nfkb1 Prkcb Raf1 Mapk3 Hras Mapk1 Prkca Nfkbia Rela Plcb1 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Acss1 Haao Mif Dbh Tyr Fah Comt Cyp2e1 Dct Cat Aldh1b1 Aldh2 Acss2 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Map2k1 Irs1 Grb2 Ptpn6 Raf1 Ghr Stat5a Stat5b Hras Mapk1 Rps6ka1 Slc2a4 Ins2 Jak2 Shc1 Mapk3 Gh Plcg1 Prkca 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Agxt Gpt Mpc1 Pcx Aars2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Ugp2 Pgm1 Ugdh Galk1 Gale Gck Uxs1 Galt PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Akt1 Plcg1 Pik3cg Prkca Pik3r6 Vav1 Plcb1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Nmnat3 Nmnat2 Nadk Nqo1 Npr1 Nmnat1 Clock Nampt Ppargc1a Rora Sirt1 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Htr7 Creb1 Gngt1 Prkacb Ppp1ca Gnb1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Ugt1a2 Slc22a8 Cyp3a16 Cyp2c50 Pdia2 Sdf2l1 Cyp2c65 Hyou1 Pdia6 Ptgs1 Pdia4 Ppib Slc22a6 Dnajb11 Ptgs2 Ugt1a9 Ugt2b1 Erp29 Ugt1a1 Hspa5 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis Pgam2 Galm Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Slc2a1 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp1a2 Cyp2c50 Slc6a2 Slc6a4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Slc9a1 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Prkar1b Kcnj4 Chrm2 Prkar2a Kcnk1 Prkar2b Kcnq1 Atp1b4 Slc8a1 Mcu Adrb1 Atp1b1 Prkacb Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cyp1a2 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Chrna4 Chrna3 Cyp2b10 Ugt1a9 Cyp2a5 Fmo3 Chrnb2 Ugt1a5 Aox1 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Tmlhe Setd7 Shmt1 Bbox1 Aldh9a1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Slc29a2 Paics Slc28a2 Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Nme2 Ak2 Ak1 Nme1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Slc29a2 Paics Slc28a2 Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Mpst Ctns Cdo1 Cth Cars1 Gclc Got1 Gclm Ldha MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Egfr Rasa1 Srf Stat6 Jak1 Egf Sos1 Stat3 Stat2 Mapk8 Stat1 Shc1 Map3k1 Elk1 Mapk3 Jun Fos Map2k1 Grb2 Raf1 Hras Map2k4 Prkcb Plcg1 Prkca FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Gmds Pfkl Tpi1 Fbp1 Aldoa Gmppa Pmm1 Mpi Uxs1 Akr1b1 Sord Khk Pfkfb1 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cbs Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Pdxp Pnpo Aox1 Pdxk Alpl NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Ugp2 Galk2 Pgm1 Ugdh Gale Uxs1 Hk1 Galt EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Agt Ace PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Mars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Tyms Ces1d Tymp Cda Slc28a1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Flad1 Rfk Acp1 Enpp1 Tyr ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Ugt1a2 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Pdia2 Slc6a4 Sdf2l1 Slc6a3 Hyou1 Adra1a Pdia6 Scn10a Pdia4 Pcsk2 Ppib Chrna4 Dnajb11 Oprm1 Htr1a Ugt1a9 Erp29 Ugt1a1 Hspa5 Atp1a2 Atp1a1 Atp1a3 Cacna1a Ugt2b36 Ugt2b1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Hsd17b10 Acat1 Hadh Acadl Acads Acaa2 Echs1 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Plpp1 Gnpat Cept1 Agps Agpat1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Sult1a1 Chst11 Sult2b1 Suox Papss2 Bpnt1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Agt Ace CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Ptgs1 Cyp3a16 Ptgs2 Cyp2d22 Ugt1a9 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Nme2 Ak2 Ak1 Nme1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Atp1a2 Atp1b1 Atp1a1 Atp1b3 Atp1a3 Gck Atp1b2 Treh Slc2a2 Slc5a1 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Cyp3a13 Maoa Cyp2d22 Cyp2c50 Aox1 Slc6a4 Maob ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Slc25a22 Gpt Slc1a4 Glud1 Slc38a4 Slc2a4 Slc2a2 Gpt2 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Tyms Rrm2b Dck Cmpk1 Nme1 Dctd Nt5c Slc28a3 Slc29a1 Slc28a1 Ctps1 Rrm1 Rrm2 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Gls2 Glud1 Pkm Pcx Sdhd Sdhc Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Pdha1 Idh3g Suclg1 Mdh1 Pgd Pklr Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Ldha Dlst Pdhb Aldob Idh3b Aco2 Dlat Aco1 Dld Rpia Gpi Pfkl G6pdx Pgk1 Taldo1 Tkt Slc2a2 Slc1a5 Hk2 Slc16a1 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Gls2 Glud1 Pkm Pcx Pfkp Sdhb Sdha Cs EG433182 Dhtkd1 Suclg1 Mdh1 Pgd Mpc1 Suclg2 Fh Idh1 Idh3a Pdhb Idh3b Aco2 Dlat Tktl2 Aco1 Pdha2 Dld Slc16a4 Slc1a2 Rpia Gpi G6pdx Pgk1 Taldo1 Hk2 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Sc5d Cyp51a1 Hsd17b7 Nsdhl Msmo1 Dhcr7 Lbr Dhcr24 Ebp ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Tyk2 Mapk1 Jak1 Stat3 Mtor IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway Bche Oprm1 Ces2h Ces1d INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Vac14 Synj1 Plcb4 Pik3c3 Ptpmt1 Cct3 Pik3ca Ipmk Bpnt2 Impa1 Isyna1 Becn1 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Map2k1 Raf1 Hras Pik3ca Vav3 Rala Ralbp1 Casp9 Pld1 Rhoa Bad Ralgds Bcl2l1 Smad3 Elk1 Smad4 Chuk Apaf1 Akt1 Foxo4 Mapk3 Rac1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Cyp11a1 Agtr1a Hsd3b6 Gng2 Cyp21a1 Gnaq Gnb1 Cyp11b2 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Ddc Pnmt Th ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Egfr Abcb1a Abcg2 NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Mpst Ctns Cdo1 Cth Cars1 Gclc Got1 Gclm Ldha ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b Itgb3 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Itpr1 Akt1 Adcy1 Rock1 Lpar5 Srf Gng2 Gnb1 Plcb1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Aldh1a1 Cyp3a16 Aldh3a1 Cyp2b10 Cyp2a5 Cyp2c65 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Glp1r Slc10a2 Gpbar1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Map2k1 Irs1 Grb2 Insr Raf1 Hras Mapk1 Slc2a4 Ins2 Sos1 Mapk8 Shc1 Akt1 Pik3cg Pik3r6 Irs2 Map2k2 Pdpk1 Foxo1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Lars1 Rps19 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Synj1 Nudt3 Ipmk Bpnt2 Impa1 Isyna1 Ip6k1 Ppip5k1 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Vac14 Synj1 Plcd4 Pik3c3 Pik3r4 Impa1 Becn1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b Itgb3 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Prkacb Drd1 Adcy2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Cyp3a13 Cyp3a16 Cyp2c50 Cyp2b10 Ephx1 Cyp2c65 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Cdkn1a Pcna Ccne1 Ccnd1 Gadd45b Cdk4 Cdk2 Bcl2 Cdk1 E2f1 Bax Rb1 Apaf1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C9 C8a Cfb C1qb C1qa C1rb Serping1 Masp2 C2 C4a C1s2 C1qc Mbl2 Cfd C3 C5 C6 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psma4 Ubc Psmc6 Psma3 Psmc5 Psma6 Psma5 Psmc2 Psmc1 Psma2 Psmc4 Psmc3 Psma1 Ubd Psmd13 Ube2e1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmd4 Psmb2 Stub1 Uba1 Psma7 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Itpr1 Mapk8 Map3k1 Elk1 Map2k7 Jun Map2k1 Grb2 Raf1 Hras Mapk1 Pld1 Gna11 Src Fshb Lhb Gnrh1 Prkcb Gnrhr Hbegf Camk2a Cga Adcy5 Prkca Cdc42 Egr1 Mmp14 Erbb4 Lrrc7 Mmp2 Actn4 Plcb1 Atf4 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Nat1 Cyp3a16 Cyp1a2 Xdh Cyp2a5 Cyp2c65 Cyp2e1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Cyp3a16 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Gmds Gmppb Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Hk1 Fbp1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk Pfkfb1 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis Gpi Hk2 Pkm Pfkp EG433182 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Cd79a Nfatc4 Nfatc1 Nfatc3 Nfatc2 Sos1 Ppp3cc Btk Mapk8 Shc1 Map3k1 Elk1 Mapk3 Rac1 Ppp3ca Jun Vav1 Ppp3cb Syk Fos Map2k1 Lyn Cd79b Grb2 Orai1 Blnk Raf1 Hras Prkcb Plcg1 Prkca LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Itpr1 Akt1 Adcy1 Rock1 Srf Gng2 Lpar1 Gnb1 Plcb1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Acat1 Hmgcl Bdh1 Oxct1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 Asns LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Mpo Cyp3a16 Top2a PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pcyt2 Pisd Pcyt1a Cept1 Pemt Chka HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Itpk1 Vac14 Sacm1l Inpp1 Minpp1 Pik3r4 Cct3 Ambra1 Pik3ca Plcd1 Itpka Miox Ptpmt1 Pi4ka Impa1 Isyna1 Becn1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Casp3 Gzmb Hmgb2 Endog Dffa Cad Casp7 Top2a GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b Itgb3 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Prkar1b Prkar2a Prkar2b Gngt1 Prkacb Prkar1a Adcy10 Prkaca Gnb1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Kars1 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Tktl2 Rpe Rpia Pgm1 Dera Prps1 Gpi G6pdx Taldo1 Pfkp Fbp1 Rbks TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Gusb Ugt8 Hk1 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C9 C2 C4a C8a C1s2 C1qc C1qb C3 C1qa C1rb C5 C6 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis Pgam2 Bpgm Galm Pgam1 G6pc1 Gpi Pkm Pfkm Tpi1 Slc2a2 Aldob EG433182 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Fbp1 Hk1 Sord Aldoa CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Gusb Ugt8 Hk1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Nmnat2 Nt5c2 Nadk Enpp1 Pnp Nudt12 Nnmt Qprt Nmrk1 Bst1 Nampt Nnt Aox1 Nadsyn1 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Gpi Hk1 Sord ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Cyp3a16 Abcb1a Pdia2 Sdf2l1 Hyou1 Top2a Mpo Pdia6 Ptgs1 Pdia4 Ppib Dnajb11 Ptgs2 Erp29 Ugt1a1 Hspa5 Abcc3 Top2b IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Slc22a1 Abcb1a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Aanat Tph1 Kmo Inmt Aadat Wars2 Ddc Wars1 Tdo2 Kynu Cyp1a1 Acmsd Haao Ido1 Cat Aldh2 Afmid LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Ikbkb Traf6 Pfkp Slc25a1 Sdhd Ikbkg Sdhc Myd88 Sdhb Ly96 Nfkbia Sdha Cd14 Cs Tirap Tlr4 Nfkb1 Chuk Acaca Mdh1 Acly Me1 Rela HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Avpr2 Gngt1 Fshr Prkacb Gng12 Gnb1 Adcy2 COAGULATION%SMPDB%SMP0000586 Coagulation Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Cat Aldh1b1 Aldh2 Acss1 Acss2 Cyp2e1 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Gars1 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Gaa Ugp2 B4galt1 G6pc1 Pgm1 Gale Glb1 Lct Gla Akr1b1 Hk1 Galt BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Sc5d Cyp51a1 Hsd17b7 Nsdhl Msmo1 Dhcr7 Lbr Dhcr24 Ebp TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Tubb1 Slco1b2 Abcb1a Abcg2 Abcc1 Tuba1b Abcc2 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Nmnat3 Nmnat2 Aifm2 Nadk Cd38 Nqo1 Nmnat1 Nampt Trp53 Sirt1 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Gls2 Glud1 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh2 Idh3a Ldha Dlst Me1 Slc7a7 Pdhb Idh3b Aco2 Dlat Dld Got2 Mycbp Slc38a5 Slc1a5 Slc1a4 Acly Slc16a1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Rpe Rpia Tpi1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Atp1a2 Clcnkb Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Slc12a6 Slc12a1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Eprs1 Rpl4 Rps16 Rps15a Rps18 Rps19 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Ddc Pnmt Th SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Map2k1 Raf1 Hras Mapk1 Nfkbia Nfkb1 Gngt1 Mapk3 Cxcl12 Plcg1 Pxn Ptk2b Pik3c2g Crk Ptk2 Bcar1 Cxcr4 Gnai1 Gnaq Gnb1 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Agt Agtr1a Ace DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Maoa Grin2a Cyp2c50 Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Maob Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Aox1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Fbp2 Aldoc Pfkm Tpi1 Hk1 Aldob LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Cyp3a16 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cyp1a2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Agxt Gpt Mpc1 Pcx Aars2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Tnf Map2k6 Map4k2 Map2k3 Tradd Cradd Ikbkb Mapk14 Ikbkg Mapk8 Nfkbia Map3k1 Nfkb1 Chuk Map2k7 Map2k4 Jun Casp2 Ripk1 Tank TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Akt1 Plcg1 Prkca Pik3r6 Plcb1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Hadha Hadhb Hadh Acadl Cpt2 Acaa2 Cpt1a Slc25a20 Acsl1 Echs1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Inpp1 Itpka Nudt4 Ip6k2 Inpp4a Ipmk Impa1 Isyna1 Ppip5k1 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Bpgm Pck1 Pgam1 G6pc1 Gpi Pank3 Pcx Tpi1 Slc2a2 Fbp1 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Aldob PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Grin2a Kcnd2 Cyp2b10 Cyp2a5 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Ugt1a9 Ugt1a5 Atp1a2 Atp1a1 Atp1a3 Cacna1a Chrna3 Atp1b1 Fmo3 Cacnb1 Atp1b3 Atp1b2 Aox1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Maoa Aldh3a1 Aoc1 Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Carns1 Hars2 Aldh2 Ftcd Hal Cndp1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Iars1 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Slc25a11 Got2 Slc25a12 Mdh2 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Aldh7a1 Gnmt Mat2a Chdh Dmgdh Shmt2 Sardh Slc44a1 Bhmt Slc44a2 Mtr Shmt1 Mat2b PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C9 Masp2 C2 C4a C8a Mbl2 C3 C5 C6 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca Fasn CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Tyms Ces1d Tymp Cda Slc28a1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rars1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Mpo Cyp3a16 Top2a TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Slc25a11 Pdha1 Mdh1 Mpc1 Pcx Acly Me1 Pdhb CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway P2ry12 Cyp3a16 Cyp1a2 Cyp2c50 Cyp2b10 Pon1 Abcb1a CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Adra1a Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Hadha Hsd17b10 Hadhb Acaa2 Mecr Echs1 Ppt1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Tnf Map2k6 Map2k3 Mapk14 Sos1 Btk Mapk8 Gab2 Map2k7 Fyn Rac1 Il13 Syk Pla2g4a Fcer1a Il4 Il5 Map2k1 Kras Lyn Pdk1 Grb2 Ms4a2 Nras Raf1 Fcer1g Pik3r1 Csf2 Lat Lcp2 Hras Mapk1 Pik3ca Vav3 Akt1 Map2k4 Plcg1 Prkca Map2k2 Inpp5d DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Gls2 Glud1 L2hgdh Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Tktl2 Rpia Gpi Prps2 G6pdx Taldo1 Pfkp Fbp1 Rbks Rpe Pgm1 Dera Pgls SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Creb1 Mapk3 Ikbkb Mapk1 Prkca Nos3 Ikbkg Plcb1 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Btd Hlcs Acacb Spcs1 LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 Asns ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Gad1 Cdo1 Csad Ado Ggt6 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Slc29a2 Paics Slc28a2 Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Abcc4 Entpd8 Abcc5 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Aox1 Nme6 Adk Ppat Tpmt Ampd1 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Ngf Fgf1 Ccnd1 Chaf1a Hoxb9 Btg2 Rb1 Btg1 Prmt1 Trp53 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Gucy1b1 Nos3 Trpv4 Prkg2 Prkg1 Gucy1a1 Trpc7 Kcnq5 Kcnq4 Trpc4 Kcnq3 Gucy1a2 Trpc3 Kcnq2 Adcy10 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp3a16 Cyp2d22 Cyp1a2 Cyp2c50 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Dck Cmpk1 Nme1 Slc22a1 Nt5c Pgk1 Abcb1a Abcg2 Abcc4 Abcc1 Abcc2 Slc22a2 Pcyt2 Pcyt1a Sult1a1 Slc22a3 Abcc3 Chpt1 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Abcb1a Slc6a2 Slc6a4 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Ugp2 Pgm1 Ugdh Galk1 Gale Gck Uxs1 Galt ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c65 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Cyp3a16 Abcb1a Pdia2 Sdf2l1 Hyou1 Top2a Mpo Pdia6 Ptgs1 Pdia4 Ppib Dnajb11 Ptgs2 Erp29 Ugt1a1 Hspa5 Abcc3 Top2b OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Gusb Ugt8 Hk1 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification Gsto1 Aqp9 Aqp7 Pnp Slc2a4 As3mt Slc2a1 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Farsb Il4i1 Gstz1 Got1 Hgd Tat Pah Yars1 Fah Hpd Farsa HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Itpk1 Inpp4b Nudt3 Inpp1 Minpp1 Itpka Impa1 Isyna1 Ip6k1 Ppip5k1 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Sars1 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Itpr1 Akt1 Lpar2 Adcy1 Rock1 Srf Gng2 Gnb1 Plcb1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway Klb Fgf15 Nr1h4 Fgfr3 Slc10a2 Fgfr4 Fgfr1 Fgfr2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Galm Slc2a13 Pgk2 Aldob Gapdhs PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Sntb1 Abcc8 Cacnb1 Cacna2d2 Cacna1a Scn5a Gcg Slc2a2 Snta1 Sntb2 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Gmds Gmppb Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Hk1 Fbp1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk Pfkfb1 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Gngt1 Prkacb Ptgir Myl3 Gnb1 Adcy2 Mylk CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Ikbkb Mapk14 Traf6 Ikbkg Mapk8 Nfkbia Map3k1 Ecsit Tollip Nfkb1 Irak1 Tlr1 Chuk Tlr9 Tab3 Tlr8 Tlr7 Tab2 Tlr6 Tab1 Tlr5 Tlr3 Tlr2 Rela Map3k7 Myd88 Ly96 Cd14 Tirap Tlr4 Map2k4 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Cyp3a16 Abcb1a Abcg2 Pdia2 Sdf2l1 Abcc1 Abcc2 Hyou1 Pdia6 Pdia4 Ppib Bche Dnajb11 Ces2h Ces1d Ugt1a9 Top1 Erp29 Ugt1a1 Hspa5 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Coasy Enpp1 Vnn1 Pank1 Ppcs Ppcdc METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Agt Ace 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Map2k6 Ikbkb Rps6ka1 Mapk8 Nfkbia Map3k1 Bad Nfkb1 Elk1 Chuk Map2k7 Jun Atf2 Arhgef7 Adora2a Pak1 Braf Map3k4 Nfkb2 Prkcz Hras Mapk1 Rap1a Pard6a Pik3ca Rapgef3 Rapgef2 Mapk11 Akt1 Creb1 Gngt1 Prkacb Map2k2 Pdpk1 Gnb1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Itpr1 Prkca Gnaq Plcb1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Hadha Hsd17b10 Hadhb Acaa2 Mecr Echs1 Ppt1 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Tars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Glud1 Pkm Sdhd Sdhc Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Suclg1 Mdh1 Pklr Mpc1 Fh Idh1 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Rpia Gpi Pfkl G6pdx Pgk1 Taldo1 Tkt Slc1a3 Hk2 Gls Slc16a1 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Ugp2 Pgm1 Ugdh Galk1 Gale Gck Uxs1 Galt PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps15 Rps17 Rpl15 Rpl8 Rps20 Rps24 Rps14 Rpl4 Aars1 Rps16 Rps15a Rps18 Rps19 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Tubb1 Cdkn1a Abcc10 Cyp3a16 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b Abcc2 Trp53 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Adra1a Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Agt Ace BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Nudt11 Prex1 Ipmk Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Maoa Aldh3a1 Aoc1 Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Carns1 Hars2 Aldh2 Ftcd Hal Cndp1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Cyp3a16 Cyp2c50 Pde4d MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Hadha Hadhb Hadh Acadm Acaa2 Slc25a20 Echs1 Acsm1 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Sult1a1 Chst11 Sult2b1 Suox Papss2 Bpnt1 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Hsd11b1 Akr1d1 Srd5a1 Hsd17b3 Pdia2 Sdf2l1 Akr1c6 Cyp19a1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Cyp11b1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 Cyp2c65 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Pdha1 Idh3g Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Kdr Flt1 Vegfa NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Ugt1a2 Pdia2 Sdf2l1 Ugt2b36 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Oprm1 Ugt1a9 Ugt2b1 Erp29 Ugt1a1 Hspa5 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Tktl1 Taldo1 Pfkm Rbks Rpe Pgd Dera Aldob KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Cyp3a16 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Cyp1a2 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pcyt2 Pisd Cept1 Chka Ptdss1 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Yars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Galm Slc2a13 Pgk2 Aldob Gapdhs LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Itpk1 Vac14 Inpp1 Minpp1 Pik3c3 Pik3r4 Fig4 Ambra1 Pik3ca Itpka Miox Ptpmt1 Inpp4a Pi4ka Ipmk Pikfyve Ippk Impa1 Plcd3 Isyna1 Becn1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2u1 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Hadha Ugt1a2 Hsd17b10 Hadhb Ivd Cyp2b10 Cyp2a5 Acadsb Acsm1 Ehhadh PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Dars1 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Atp1a2 Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Lct Slc2a2 Slc5a1 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Agt Ace METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Sntb1 Scn5a Snta1 Sntb2 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Aldh1a1 Abcc10 Cyp3a16 Cyp2d22 Cyp2b10 Ugt1a9 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Adam17 Egfr Prkca Erbb4 Erbb3 Psen1 Nrg2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Ccnd3 Wasf1 Cdkn1a Pcna Cfl1 Ppp1r12b Pak1 Ccnd1 Actb Cdk5 Myl2 Limk1 Pdgfra Arfip2 Vav3 Ralbp1 Pld1 Mylk Map3k1 Rac1 Cap1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cbs Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Bpgm Pgam1 G6pc1 Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Gusb Ugt8 Hk1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Tnf Tradd Ikbkb Traf6 Tnfrsf1b Tnfrsf1a Ikbkg Ncoa3 Camkk2 Nfkbia Il1a Map3k1 Il1r1 Map3k14 Nfkb1 Irak1 Chuk Ubc Tab1 Rela Map3k7 Camkk1 Myd88 Tlr4 Fadd Ripk1 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Cyp2b10 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Cyp2c65 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Sst Cckbr Hrh2 Gast Atp4a Sstr4 Atp4b Ca1 Chrm3 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect Glud1 Pkm Pcx Sdhc Sdhb Cs EG433182 Pgam2 Pdha1 Idh3g Suclg1 Mdh1 Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Dlst Pdhb Aldob Idh3b Aco2 Aco1 Dld Rpia Gpi Pfkl G6pdx Pgk1 Tkt Slc2a2 Slc1a5 Pdhx Ogdh Slc16a1 CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl4 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Hsd17b1 Cyp19a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Aldh7a1 Bhmt Ahcy Mtr Pemt Mat2b Mat2a Chdh BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Btd Hlcs Acacb Spcs1 FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Agt Ace ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Cars1 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Grb2 Pik3r1 Stat5a Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor Trp53 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Agxt Gpt Mpc1 Pcx Aars2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Cyp3a16 Impdh1 Ces2h Ces1d Ugt1a9 Slco1b2 Abcb1a Abcg2 Cyp2c65 Abcc2 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Aldh1a1 Cyp3a16 Cyp2b10 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Gstz1 Maoa Aldh3a1 Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway P2ry12 Cyp3a16 Cyp1a2 Cyp2c50 Cyp2b10 Pon1 Abcb1a TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Duox1 Tpo Tg Cyba Cybb Nox4 Nox3 Duox2 Slc5a5 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Amigo3 Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Fbp1 Mpi Akr1b1 Sord Pmm2 Aldob Khk Tgds Pfkfb1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Map2k6 Ikbkb Rps6ka1 Mapk8 Nfkbia Map3k1 Bad Nfkb1 Elk1 Chuk Map2k7 Jun Atf2 Adora2b Arhgef7 Pak1 Braf Map3k4 Nfkb2 Prkcz Hras Mapk1 Rap1a Pard6a Pik3ca Rapgef3 Rapgef2 Mapk11 Adcy2 Akt1 Creb1 Gngt1 Prkacb Map2k2 Pdpk1 Gnb1 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Bpgm Pgam1 G6pc1 Gpi Pgk1 Pfkm Slc2a2 Aldoa EG433182 Pgam2 Galm Pklr Hk2 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Sst Abcc8 Cacnb1 Cacna2d2 Cacna1a Slc2a2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Irs1 Tsc2 Insr Eif4ebp1 Tsc1 Eif4e Ins2 Akt1 Pik3cg Pik3r6 Irs2 Mtor Slc7a5 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Dhfr Cbr1 Qdpr Spr Gch1 Akr1b1 Pts Gchfr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Acat1 Hmgcl Bdh1 Oxct1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling P4ha3 Tlr4 Hif1a Il1b Sirt3 Nlrp3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Cyp3a16 Ugt1a9 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Oprk1 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Creb1 Gngt1 Prkacb Ppp1ca Htr4 Gnb1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Cyp1a1 Sult1e1 Pdia2 Sdf2l1 Hsd17b1 Comt Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Itpr1 Map2k3 Egfr Mapk14 Cacna2d2 Sos1 Mapk8 Map3k1 Elk1 Map2k7 Jun Map2k1 Grb2 Raf1 Cacna1f Cacna1c Cacna1d Hras Mapk1 Cacna1s Map3k2 Pld1 Gna11 Src Fshb Lhb Gnrh1 Adcy1 Prkcb Gnrhr Hbegf Camk2a Cga Cacnb1 Prkca Egr1 Mmp14 Mmp2 Prkaca Actn4 Plcb1 Atf4 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Vac14 Sacm1l Minpp1 Pik3c3 Pik3r4 Cct3 Ambra1 Plcd1 Itpka Miox Ptpmt1 Inpp4a Ipmk Ippk Impa1 Bpnt1 Isyna1 Inpp5j Becn1 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Echs1 Acadsb Acat1 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Map2k6 Map2k3 Ikbkb Mapk14 Traf6 Ikbkg Mapk8 Nfkbia Map3k1 Ecsit Tollip Nfkb1 Irak1 Elk1 Chuk Tlr9 Tlr7 Tab2 Tab1 Jun Tlr3 Tlr2 Fos Rela Map3k7 Myd88 Eif2ak2 Ly96 Ppara Cd14 Tirap Tlr4 Map2k4 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Nfatc4 Nfatc1 Nfatc3 Nfatc2 Sos1 Ppp3cc Mapk8 Nfkbia Shc1 Map3k1 Ptpn7 Cd3g Cd247 Nfkb1 Elk1 Cd3d Mapk3 Ubc Fyn Pik3cg Rac1 Ppp3ca Jun Vav1 Ppp3cb Fos Rela Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Pik3ca Zap70 Cd3e Map2k4 Prkcb Plcg1 Prkca MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Slc29a2 Slc28a2 Impdh1 Slc28a3 Slc29a1 Abcc4 Abcc5 Xdh Gmps Rac1 Hprt1 Aox1 Adk Ppat Tpmt FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacnb1 Cacna2d2 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Nt5c2 Tyms Gda Rrm2b Tymp Dhodh Dctd Cda Dut Upb1 Dpys Ak3 Ctps1 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Itpr1 Dlg4 Nos1 Xdh Grin2a Aldh2 Prkacb Prkca Ppp3ca Grin1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Glud1 Pkm Pcx Pfkp Sdhd Sdhc Hk1 Sdhb Sdha Cs EG433182 Dhtkd1 Pgam2 Pdha1 Suclg1 Mdh1 Pgd Mpc1 Suclg2 Pgls Fh Idh1 Idh3a Dlst Pdhb Dlat Tktl2 Aco1 Dld Slc16a4 Rpia Gpi G6pdx Pgk1 Taldo1 Gls Slc2a1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Pdxp Pnpo Aox1 Pdxk Alpl PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Cps1 Glul Gad1 Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Gmps Gfpt1 Aldh4a1 Qars1 Cad Ppat JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Synj1 Vac14 Inpp4b Pik3c2a Pten Pik3c3 Pik3r4 Egfr Pik3r1 Fig4 Cdipt Ambra1 Pik3cd Pip5k1a Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Erbb2 Plcb1 Becn1 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Atp1b1 Cacnb1 Atp1b3 Atp1b2 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Mpst Ctns Cdo1 Cth Cars1 Gclc Got1 Gclm Ldha BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Slco1a4 Nr1h4 Slc10a2 Gpbar1 Abcc4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Pex14 Crat Phyh Cpt2 Pex13 Abcd2 Aldh2 Hacl1 Slc25a20 Acsl1 Abcd1 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pck1 G6pc1 Gpi Tpi1 Fbp1 Mdh2 Aldoa Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Nme2 Lalba Ugp2 B4galt1 G6pc1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Slc6a2 Grin1 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Atp1b1 Cacnb1 Atp1b3 Atp1b2 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Cyp3a16 Cyp2b10 Pdia2 Sdf2l1 Cyp2c65 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Dlat Pck1 Dld Pcx Pdha1 Acat1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Echs1 Acadsb Pcca Bckdha Pccb Dbt Hsd17b10 Acat1 Bcat1 Auh Aox1 Hmgcl Oxct1 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Agxt Psph Sars1 Gamt Cth Aldh2 Shmt1 Sds Gldc Gatm GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Mc2r Gngt1 Prkacb Pomc Gnb1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Gusb Ugt8 Hk1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Aldh1a1 Cyp3a16 Aldh3a1 Cyp2b10 Cyp2a5 Cyp2c65 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Dlg4 Nos1 Grin2a Prkacb Prkca Ppp3ca Grin1 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Arnt Ahr Hsp90aa1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Map2k1 Grb2 Raf1 Stat5a Rasa1 Srf Hras Egf Stat3 Jak2 Mapk8 Shc1 Map3k1 Elk1 Map2k7 Prkcb Mapk3 Plcg1 Prkca Jun Erbb4 Fos LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Akt1 Adcy1 Rock1 Lpar6 Srf Gng2 Gnb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Gmds Gmppb Phpt1 Fcsk Fpgt Gfus Pfkl Tpi1 Hk1 Fbp1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk Pfkfb1 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Gusb Ugt8 Hk1 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa EG433182 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) P4ha3 Cps1 Nos1 Ckb Asl Otc Got1 Glud1 Gamt Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp1a2 Cyp2c50 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a13 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Fbp2 Aldoc Pfkm Tpi1 Hk1 Aldob PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Hars1 Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Rpia Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgd Pgm1 Dera Pgls DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Cyp2d22 Slc6a2 Slc6a4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Slc6a20a Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Lhb Creb1 Gngt1 Prkacb Lhcgr Cga Ppp1ca Gnb1 Adcy2 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Atp1a2 Atp1b1 Atp1a1 Atp1b3 Atp1a3 Atp1b2 Lct Slc2a2 Slc5a1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency Bpgm Pck1 Pgam1 G6pc1 Gpi Pcx Tpi1 Slc2a2 Fbp1 Mdh2 Aldoa EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Gpi Pkm Pfkp Tpi1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Rpia Prps1 Gpi Pfkl G6pdx Taldo1 Tkt Fbp1 Aldoa Rbks SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Hk2 Gusb Gck TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Dgat1 Gpam Gpd1 Lpin1 Agpat1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cbs Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 Dpyd GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Agl Ugp2 Pygl Ugt2b1 Ugdh Gpi Amy2a5 Hk2 Gusb Gck Pgm2l1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Dhtkd1 Dld Aldh8a1 Acmsd Dlst BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Wars1 Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Itpk1 Inpp4b Nudt3 Inpp1 Minpp1 Itpka Inpp4a Ipmk Ippk Impa1 Ip6k1 Isyna1 Ppip5k1 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Echs1 Mcee Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Ugt2b38 Hsd17b1 Cyp19a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Tpi1 Hk1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob Gapdhs KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Slc12a3 Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp4a Aqp3 Atp4b Aqp2 Slc8a1 Atp1b1 Atp1b3 Trpv5 Atp1b2 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Sntb1 Kcne1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Atp1b1 Cacnb1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Tnf Mapk8 Gab2 Map2k7 Fyn Rac1 Il13 Syk Fcer1a Il4 Map2k1 Kras Lyn Lck Grb2 Ms4a2 Nras Blnk Raf1 Pik3r1 Csf2 Lat Hras Mapk1 Akt1 Plcg1 Prkca Map2k2 Inpp5d SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Ikbkb Mapk1 Nos3 Ikbkg Mapk11 Nfkb1 Ptgs1 Chuk Creb1 Mapk3 Prkca Sucnr1 Plcb1 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Cyp3a16 Cyp2d22 Sult1a1 Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Adss2 Hprt1 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat Ampd1 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Casp3 Arhgdib Apaf1 Gzmb Parp1 Jun Arhgap5 Casp8 Casp9 Casp1 Prf1 Arhgap32 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Fbp2 Aldoc Pfkm Tpi1 Hk1 Aldob ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Nars1 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 Rps19 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Tpi1 Hk1 EG433182 Galm Slc2a13 Pgk2 Aldob Gapdhs INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Hrh2 Creb1 Gngt1 Prkacb Ppp1ca Gnb1 Adcy2 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Tm7sf2 Sqle Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Lpar3 Itpr1 Akt1 Adcy1 Gng2 Gnb1 Plcb1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Dlat Aco1 Dld Gls2 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Pdha1 Idh3g Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine)