S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation Enoph1 Adi1 Kyat1 Mri1 Apip L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III Mpst Got1 Cisd1 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) Gad1 Gad2 Glul ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II Cyp2a5 Cyp19a1 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 Ehhadh METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI Ldhd GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation Acat1 Acat2 Gcdh Echs1 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis Asns PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation Pecr Aldh3a2 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II Ubiad1 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism Impa2 Ocrl Pten Impa1 Inpp5k Inpp1 Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5f Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk Bpnt2 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) Cbs Cth SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis Dhodh Rrm1 Dut Rrm2 Tyms Rrm2b Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Dtymk Nme7 Nme6 Ntpcr Ctps2 Ctps1 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis Gphn SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis Aanat Tph2 Ddc Tph1 ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis Tm7sf2 Hsd17b7 Nsdhl Lbr &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis Fads2 Acsl1 Acsm3 Acsbg1 Acsm4 Slc27a2 Acsm5 Acsbg2 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II Rnmt Cmtr2 Cmtr1 Rngtt PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis Ggt5 Gstm4 Alox12 Gpx4 Alox5 Dpep1 Alox15 Ltc4s SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Ggps1 Acat1 Hmgcr Acat2 Mvd Hmgcs2 Fdps Idi1 Mvk Pmvk L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation Gls2 Gls L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation Gstz1 Hgd Tat Fah Hpd NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation Tomt Aldh2 Aldh3a2 Adh4 Maoa Pnmt Comt Maob N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II Gnpda1 Nagk Amdhd2 Gnpda2 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation Hal Uroc1 Amdhd1 Ftcd NADH REPAIR%BIOCYC%PWY-6938 NADH repair Naxe URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) Upb1 Dpys Dpyd SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds Plcb4 Plcb3 Pikfyve Ip6k1 Pik3c3 Plcb2 Ip6k2 Plcb1 Ip6k3 Sacm1l Pi4k2a Ippk Plcg1 Plcg2 Mtmr14 Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pip4k2c Pik3r2 Pik3r3 Pik3r4 Pip4k2a Inpp5d Pi4kb Itpka Pi4ka Plch2 Inpp5a Plch1 Plcd1 Synj1 Inpp5b Plcd4 Itpkc Plcd3 Itpkb Itpk1 Ipmk Cdipt Pik3cg Pik3cb Ocrl Pik3cd Pip4p2 Pten Pip4p1 Inpp5k Pik3ca Pi4k2b Plcz1 Synj2 Inppl1 Pik3c2b Minpp1 Plce1 Pik3c2a Pik3c2g Fig4 Pip5kl1 Mtmr3 Ppip5k1 Ppip5k2 Pip5k1c Pip5k1b Pip5k1a L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation Aldh4a1 Prodh METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I Glo1 Hagh L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation Gpt2 Gpt ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA Acss2 Acss1 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I Aoc3 Smox Sat2 Sat1 Paox L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis Pah ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing Tgm1 Aloxe3 Slc27a4 Pnpla1 Cyp4f39 Alox12b Cers3 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis Carns1 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis Cad Umps Dhodh GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation Pnp Gda Xdh Nt5c2 SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation Cat Sod3 Sod2 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis Isyna1 Impa2 Impa1 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) Cox6a1 Ndufa10 Cox7b Uqcrfs1 Ndufs1 Ndufs2 Ndufa13 Ndufs5 Cox4i1 Ndufs4 Ndufs7 Ndufs8 Coxfa4l2 Uqcrq Coxfa4 Ndufa1 Ndufa3 Ndufa2 Ndufa5 Ndufa7 Ndufa6 Ndufa9 Ndufa8 Ndufb11 Ndufb10 Cox7a2 Cox5a Cyc1 Ndufb2 Uqcrc2 Ndufb3 Uqcrc1 Ndufb6 Ndufb5 Ndufb8 mt-Nd4l Ndufb7 Ndufb9 Cox6b1 Cox8a Ndufv2 Ndufv1 Ndufv3 Uqcrb Uqcr10 mt-Co2 mt-Cytb mt-Co3 mt-Nd4 mt-Nd5 mt-Nd6 Ndufab1 Ndufc1 Ndufc2 mt-Co1 Sdhd Sdhc Sdhb mt-Nd1 Sdha mt-Nd2 mt-Nd3 Ndufa12 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis Dhdds Nus1 Srd5a3 Dolk Dhrsx PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis Adss1 Pfas Ak8 Atic Ppat Paics Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Adsl Impdh1 Guk1 Gart Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) Nmnat1 Nmrk2 Nmrk1 Nmnat3 Nmnat2 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt Gad1 Gad2 Glul Glud1 Abat PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6pdx Pgls Pgd UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) Coq5 Coq6 Coq7 Pdss2 Pdss1 Ubiad1 Coq2 Coq3 Coq4 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Impdh1 Nme1 Guk1 Gmps Nme7 Nme6 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis Vps29 Shmt2 Psat1 Shmt1 Phgdh Psph PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage Nme3 Nme2 Nme5 Nme4 Guk1 Nme1 Nme7 Nme6 Ak5 Dguok Dck THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) Sult1a1 Dio1 Dio2 Ugt1a9 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation Asns Gls2 Gls VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle Nqo1 Ggcx Vkorc1l1 Vkorc1 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I Sult1a1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Cyp1a2 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation Pnp Ada GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I Gstz1 Gsta5 Gsta3 Anpep Gstm7 Ggt5 Gstm5 Gstk1 Gstm1 Nat8 Gstm2 Gsto2 Mgst3 Gstt2 Mgst2 Gstt1 Mgst1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate Gart ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis Ptgs2 Alox5 Lta4h PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I Azin2 Agmat PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II Pcyt2 Cept1 Etnk1 Chkb Selenoi CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis Carns1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Dtymk Nme7 Nme6 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis Alox12 Gpx4 Alox15 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) Dhtkd1 Crym Aadat Pycr1 Pipox CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) Hyal5 Hyal4 Hyal1 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis Tyr ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis Atp6v0b ATP6 Atp5f1d Atp5f1c Atp5pb Atp6v1e1 Atpaf1 Atp6v0a1 Atp5pf Atp6v1c1 Atpaf2 Atp6v1a Atp6v1b2 Atp6v0d1 Vps9d1 Atp5mc3 Atp5mf Atp5me Atp6v0e1 Atp6v1g1 Atp5f1b Atp5f1a Atp6v1f Atp6v1d Atp6v1h FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation Mthfd1l Fpgs Shmt2 Shmt1 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis Vps29 Psat1 Phgdh Psph L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I Aspg Asrgl1 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I Acod1 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis Pfas Ppat Gart PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I Cda Uck1 Uck2 Uckl1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis Ggps1 Hmgcr Mvd Hmgcs2 Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss Acat1 Acat2 Fdps Idi1 Mvk Pmvk PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III Arg2 Odc1 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation Cda Upp1 Upp2 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis Bdh2 Acat1 Bdh1 Hmgcs2 Hmgcl D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation Dcxr Cryl1 Akr1a1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis Pi4k2b Plcz1 Plce1 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Plcb4 Plcb3 Plcb2 Plcb1 Pi4k2a Plcg1 Plcg2 Pip4k2b Pip4k2c Pip4k2a Pi4kb Pi4ka Plch2 Plch1 Plcd1 Plcd4 Plcd3 Cdipt ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV Aldh2 Aldh3a2 Acss2 Acss1 Cat CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) Cyp2e1 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation Acat1 Acat2 Hsd17b10 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Acadsb Echs1 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis Agxt2 Agxt ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) Elovl7 Fads1 Fads2 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis B3galt1 B3gnt5 B3gnt2 Fut2 Fut1 A4galt B4galt4 B4galt6 B4galnt1 Gbgt1 St3gal6 St3gal4 St3gal5 St3gal2 B4galt1 B4galt2 B4galt3 B3galnt1 St6gal1 B3galt5 B3galt4 St8sia2 St8sia3 Ugcg St8sia1 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I Hmox1 Hmox2 Blvra Ugt1a5 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III Ptdss2 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis B4galt1 B4galt2 B4galt3 St6gal1 St8sia2 St8sia3 Ugcg B3gnt5 B3gnt2 B4galt4 B4galt6 St3gal6 St3gal4 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) Fcsk Fpgt GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) Gmds THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III Tpk1 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation Upb1 Dpys Dpyd S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation Mtap NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation Nnt Nadk CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation Chdh Aldh7a1 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI Adk PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis Chka Peds1 Agpat1 Pcyt2 Cept1 Etnk1 Chkb Selenoi Gnpat Pcyt1b Pcyt1a Agps Far2 Far1 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis Tyr L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) Afmid Haao Got2 Aldh8a1 Kyat3 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Dhtkd1 Aadat Kyat1 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) Hsd17b1 Hsd17b7 Cyp2a5 Cyp19a1 Hsd17b11 Hsd17b3 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) Elovl7 Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation Suox HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis Hdc GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis St6gal1 B3galt4 B4galt6 Ugcg B4galnt1 St8sia1 St3gal5 St3gal2 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide B3galt1 Abo B3galt5 Fut2 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III Akr1b10 Cyp2e1 Akr1b1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis Mat2a Mat2b Mat1a PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation Enpp2 Tmem86b SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis Dhodh Cad Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Umps Nme7 Nme6 Ctps2 Ctps1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) Ippk Itpk1 Ipmk GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis Shmt2 Shmt1 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis Fads6 Acot2 Scd1 Acot3 Acot4 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis Cbr1 Ptgs2 Tbxas1 Hpgds Hpgd Akr1c18 Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation Ocrl Pip4p2 Pten Pip4p1 Inpp5k Synj2 Sacm1l Inppl1 Inpp5e Mtmr14 Inpp4a Mtmr3 Inpp4b Tpte Inpp5d Inpp5f Synj1 Inpp5b ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis Elovl4 Tecr Hsd17b12 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) Ppcs Ppcdc Coasy RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis Ephx3 Alox12 Gpx4 Alox5 Alox15 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis Ptgs2 Tbxas1 Hpgds Hpgd Ptges Ptgds Ptgis Ptges2 Ptgs1 Ptgr2 Ptgr1 Ggt5 Gstm4 Ephx3 Alox8 Alox12 Dpep2 Gpx4 Alox5 Cyp4f15 Dpep1 Cyp2j6 Alox15 Cyp4f3 Ltc4s Cyp2d22 Lta4h PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination Padi1 Padi6 Padi2 Padi3 Padi4 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) Pah PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II Ptdss2 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis Ocrl Pten Inpp5k Synj2 Inppl1 Minpp1 Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpkb Ipmk INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis Ip6k1 Ip6k2 Ip6k3 Ippk Ipmk Ppip5k1 Ppip5k2 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism Dio1 Dio3 Dio2 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway Txnrd1 Txnrd3 Txnrd2 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis Ptgs2 Alox5 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate Acly KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis Bdh2 Acat1 Bdh1 Oxct1 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation Aldh1b1 Dera Aldh3b1 Aldh3a1 Pgm2 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation Alox12 Alox5 Alox15 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine Bhmt Bhmt2 Mtr SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation Sult1a1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Maoa Cyp1b1 Cyp2c50 Cyp1a2 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA Dhtkd1 Aldh8a1 Acmsd GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions Gpx1 Gpx3 Gsr Gpx7 Gpx4 Gpx2 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage Nampt Nmnat1 Nmnat3 Nmnat2 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation Aoc1 Hnmt CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis Mboat1 Abhd5 Mboat2 Agpat1 Agpat3 Lclat1 Agpat4 Agpat2 Cds2 Cds1 Gpat4 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt Bpgm Minpp1 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III Aldh3a2 Fa2h Hacl1 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis Fbp2 Bpgm Gpi Tpi1 Pcx Mdh1 Mdh2 Gapdhs Aldob Aldoc Eno3 G6pc1 Eno2 Aldoa G6pc2 G6pc3 EG433182 Pgk1 Pgam2 Pgam1 Pgk2 Fbp1 Pck1 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I Aoc2 Aldh2 Aldh3a2 Aoc3 Maoa Maob PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) Rpia Rpe Taldo1 Tkt VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II Elovl7 Tecr Elovl1 Hsd17b12 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) Elovl7 Fads1 Fads2 Acsl1 Elovl5 Acsm3 Hsd17b12 Acsbg1 Acsm4 Slc27a2 Acsm5 Acsbg2 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis Itpk1 Ipmk &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle Ggt5 Gclc Gss Cndp2 Gclm Oplah UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I Ntpcr Ctps2 Ctps1 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis Pygl Pygm Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Pygb Mgam Hkdc1 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation Hibch Acad8 Bckdhb Hibadh Bckdha Aldh6a1 Dbt Bcat1 Dld Abat Bcat2 Echs1 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) Metap2 Ntan1 Ate1 Naa20 Naa25 Ntaq1 Metap1 Apeh ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis Ptgs2 Alox5 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis Got1 Got1l1 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification Nudt1 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II Hk2 Gck Pgm1 Hk1 Pgm2 Hk3 Hkdc1 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II Maoa TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II Tsen34 Rtcb Tsen15 Ddx1 AI597479 Rtraf Tsen54 Fam98b Zbtb8os Tsen2 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage Cda Tk2 Tyms Tk1 Dck PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis Rrm1 Dut Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Dtymk Nme7 Nme6 Ntpcr L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis Aldh18a1 Pycr2 Pycr1 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification Gsta5 Gsta3 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation Nt5c1a Nt5e Nt5c3a Impdh1 Pnp Gda Xdh Nt5c2 Ada L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis Ahcy Mat2a Mat2b Mat1a Cbs Cth L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle Mtap Mat2a Srm Mat2b Mat1a Enoph1 Adi1 Kyat1 Mri1 Apip D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation Impa2 Ocrl Impa1 Inpp5k Inpp1 Synj2 Inppl1 Inpp5f Inpp5a Synj1 Inpp5b Bpnt2 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation Acadsb BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway Bmpr2 Bmp2 Smad4 Acvr2a Bmpr1b Zfyve16 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis Ggt5 Gstm4 Dpep2 Alox5 Dpep1 Ltc4s Lta4h PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis Hsd3b6 Hsd3b1 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis Glud1 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II Rbp1 Xdh Rbp4 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis Gclc Gss Gclm DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation Aldh3a2 Maoa Comt Maob MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis Ephx3 Alox12 Alox15 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I Got1 Got1l1 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis Gal3st1 Ugt8 St3gal5 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I Sord PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate Ldha Ldhb Ldhc PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III Aldh2 Aldh3a2 Aldh1b1 Aldh3b1 Aldh3a1 Maoa Sat2 Sat1 Maob CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis Ckmt1 Ckmt2 Ckm Ckb QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) Qtrt2 Qtrt1 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation Mccc2 Hmgcll1 Bckdhb Bckdha Dbt Bcat1 Dld Bcat2 Mccc1 Auh Hmgcl Ivd GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle Gpd1 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation Got1 Aga Aspg Asrgl1 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation Sult1a1 Aldh2 Aldh3a2 Maoa ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis Adss1 Ak8 Adsl Ak1 Ak3 Ak2 Ak5 Adss2 Ak7 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis Acot9 Acot7 Acot8 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II Plaat3 Plaat1 Plaat5 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde Afmid Haao Kmo Tdo2 Kynu Ido2 Ido1 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis Uxs1 Ugdh PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases Plcz1 Plce1 Plaat3 Plaat1 Plaat5 Pla2g2e Pla2g4f Plcb4 Pla2g2d Plcb3 Pla2g2f Pla2g4c Pla2g4e Pla2g4d Pld4 Plcb2 Pla2g4a Pld1 Plcb1 Plb1 Pld3 Pld2 Pla2g12a Pnpla8 Plcg1 Pla2g5 Plcg2 Pla2g3 Pla2g6 Pla2g1b Oc90 Pla2g10 Plch2 Plch1 Plcd1 Plcd4 Plcd3 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis Sqle Fdft1 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis Srd5a1 Srd5a2 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis Got1 Gclc Gss Gclm COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis Ppcs Pank3 Ppcdc Pank2 Coasy Pank1 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation Aldob Aldoc Tkfc Aldoa Sis Khk Tpi1 PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis Prps1 Prps2 Prps1l1 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage Tk2 Tyms Tk1 Nme3 Nme2 Nme5 Nme4 Cmpk2 Cda Nme1 Cmpk1 Dtymk Nme7 Nme6 Dck PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis Chka Cept1 Chkb Pcyt1b Pcyt1a Chpt1 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization Afmid Haao Akr1a1 Nmnat1 Aldh8a1 Kmo Tdo2 Nmnat3 Nmnat2 Kynu Ido2 Maoa Acmsd Ido1 Maob Dhtkd1 Aldh2 Sult1a1 Aanat Tph2 Ddc Tph1 Cyp2a5 Por Cyp4x1 Cyp2u1 Cyp2s1 Cyp1b1 Cyp2c50 Gcdh Cyp1a2 Echs1 Acat1 Acat2 Aldh3a2 Qprt Nadsyn1 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) Acox2 Scp2 Hsd17b4 Acaa1a Hadh Hsd17b10 Acsbg1 Ehhadh Slc27a2 Echs1 Acox1 Acsbg2 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine Ddc Aldh3a2 Akr1a1 Maob TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging Lars2 Gars1 Qars1 Lars1 Vars1 Farsa Farsb Cars2 Cars1 Vars2 Wars2 Aars2 Rars1 Wars1 Aars1 Rars2 Kars1 Sars2 Sars1 Fars2 Eprs1 Nars1 Nars2 Tars3 Tars2 Iars1 Iars2 Tars1 Ears2 Hars1 Pars2 Mars1 Mars2 Dars2 Yars2 Yars1 Hars2 Dars1 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage Pdxk Pnpo N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I Gnpda1 Amdhd2 Gnpda2 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis Tat SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage Adss1 Ak8 Rrm1 Rrm2 Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Nme6 Pnp Aprt Hprt1 Ada Adsl Impdh1 Guk1 Adk Ak1 Ak3 Gmps Ak2 Ak5 Adss2 Ak7 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Cers1 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP Rrm1 Rrm2 Tyms Rrm2b Nme3 Nme2 Nme5 Nme4 Dctd Nme1 Dtymk Nme7 Nme6 Ntpcr UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 Ctps2 Ctps1 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine Dmgdh Chdh Aldh7a1 Shmt2 Shmt1 Bhmt TCA CYCLE%BIOCYC%PWY66-398 TCA cycle Ogdh Aco2 Sucla2 Dld Mdh1 Mdh2 Fh Sdhd Idh3a Sdhc Dlst Sdhb Idh3b Sdha Cs Idh3g Suclg1 Suclg2 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis Emg1 Tsr3 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation Scp2 Hadh Hadha Hsd17b10 Hadhb Acaa2 Eci1 Acsbg1 Slc27a2 Echs1 Acsbg2 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis Sptlc1 Sptlc2 Sptlc3 Sptssa Degs1 Kdsr Cers1 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) Elovl7 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II Sord Adh1 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis B3galt1 B3gnt5 St6gal1 B3galt5 Fut2 B4galt6 Ugcg St3gal5 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation Sdsl TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling Pcbd2 Pcbd1 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis Srm TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis Gch1 Spr Pts L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) Afmid Haao Aldh8a1 Kmo Tdo2 Kynu Ido2 Acmsd Ido1 Gcdh Echs1 Dhtkd1 Acat1 Acat2 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation Oga Ogt CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis Hccs RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I Rbp1 Aldh1a2 Rdh16f2 Aldh1a1 Aldh1a3 Sdr16c5 Rbp4 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide B4galt1 B4galt2 B4galt3 Abo Fut1 St8sia2 Fut9 Chst1 St3gal4 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation Nme3 Nme2 Nme5 Nme4 Cmpk2 Nme1 Cmpk1 Nme7 Nme6 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation Cda Upb1 Dpys Upp1 Dpyd Upp2 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) Dio1 Dio3 Dio2 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) Fads1 Fads2 Acsl1 Elovl5 Acsm3 Acsm4 Acsm5 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis B4galt1 B4galt2 B4galt3 B3gnt2 Gcnt3 Gcnt2 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) Eci1 Eci2 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis Pfkm Pfkp Bpgm Gpi Tpi1 Hk3 Hkdc1 Gapdhs Aldob Aldoc Hk2 Eno3 Gck Eno2 Hk1 Aldoa EG433182 Pgk1 Pgam2 Pgam1 Pklr Pgk2 Pfkl Pkm HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) Cbs Cth HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis B4galt1 B4galt2 Lalba St6galnac6 St6gal1 B3gnt2 B3galt5 Fut2 B4galt4 Gcnt3 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation Nt5e Impdh1 Pnp Xdh Nt5c2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I Fech Cpox Urod Ppox MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle Cpt1a Cpt2 Cpt1b Cpt1c Slc25a20 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis Tyr Dct Trpc1 Tyrp1 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) Oxsm Acsf3 Mcat Ndufab1 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation Faah FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) Esd Adh5 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis B3galnt1 B3galt5 Fut2 Fut1 A4galt B4galt6 Ugcg Gbgt1 St3gal2 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation Hk2 Gck Hk1 Treh Hk3 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis Ephx3 Ephx1 Ephx2 Ephx4 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) Rpe65 Rbp1 Rbp2 Rbp3 Rdh5 Dhrs9 Lrat Rlbp1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis Srd5a1 Srd5a2 Akr1c18 Cyp17a1 Hsd3b6 Hsd3b1 Hsd17b3 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis Nme3 Nme2 Nme5 Nme4 Impdh1 Guk1 Nme1 Nme7 Gmps Nme6 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis Rbp1 Rbp2 Dhrs9 Lrat Ces4a Ces5a Pnlip Lipc Ces2h Ces1d Bco1 Dhrs4 Dhrs3 Rdh8 Rdh11 Rdh12 Rdh10 Rbp4 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis Ptgs2 Ephx3 Alox12 Gpx4 Alox5 Alox15 Cyp2d22 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis Pik3cb Pik3cd Pik3ca Pi4k2b Pik3c2b Pik3c2a Pik3c2g Fig4 Pip5kl1 Pip5k1c Pip5k1b Pip5k1a Pikfyve Pik3c3 Sacm1l Pi4k2a Pik3r5 Pik3r6 Pip4k2b Pik3r1 Pik3r2 Pik3r3 Pik3r4 Pi4kb Pi4ka Cdipt Pik3cg UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II Gnpnat1 Uap1 Gnpda1 Pgm3 Hk2 Gck Gnpda2 Hk1 Gpi Hk3 Gale Hkdc1 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I Abat CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis Hkdc1 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I Got1 Cdo1 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis Elovl7 Elovl6 Acot7 Acsl1 Hsd17b12 Acsbg1 Acot2 Slc27a2 Acot3 Acsbg2 Acot4 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation Abat TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation Aldh4a1 Got2 Hoga1 Prodh2 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation Cyp4f15 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) Fads2 Elovl2 Elovl5 Hsd17b12 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis Lss SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism Acsl1 Acsbg1 Ptgr1 Slc27a2 Acsbg2 Acer1 Acer2 Asah2 Asah1 Sphk2 Sphk1 Sgpp2 Sgpp1 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate Pnp Pgm2 Ada PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation Cda Upp1 Upp2 Tymp D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism Pip4p2 Pip4p1 Plcb2 Plcb1 Plcz1 Plce1 Plcg1 Plcg2 Mtmr14 Mtmr3 Pip4k2c Pip4k2a Plch2 Plch1 Plcd1 Plcd4 Plcd3 Plcb4 Plcb3 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis Akr1c21 Srd5a1 Akr1c6 Srd5a2 Akr1c18 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I Mthfd1l Mthfd2l Aldh1l1 Mthfsl Aldh1l2 Mthfd2 Mthfr Shmt2 Shmt1 Mtr GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation Gk5 Gk Gk2 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation Mpi L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation Ahcy Mat2a Mat2b Mat1a ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III Pnp Hprt1 Ada REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation Gpx1 Gpx3 Gpx7 Gpx6 Cat Gpx5 Gpx8 Sod3 Gpx2 Sod2 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation Nt5c1a Nt5e Nt5c3a Pnp Xdh Nt5c2 Ada ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) Akr1b10 Cyp2e1 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis Bbox1 Aldh9a1 Shmt1 Tmlhe 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) Ocrl Inpp5k Synj2 Inppl1 Ippk Inpp5d Itpka Inpp5a Synj1 Inpp5b Itpkc Itpkb Itpk1 Ipmk LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis Alox8 Alox12 Gpx4 Alox5 Alox15 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation Lipg Dagla Lipe Lipf Lpl Pnpla3 Daglb Cel Pnliprp2 Pnlip Lipc Pnpla2 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) Nanp Nans Cmas Gne CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis Pgs1 Ptpmt1 Crls1 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation Comt CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis Gamt Gatm UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) Ugdh GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis Pfkfb4 Pfkfb3 Tigar Pfkfb2 Pfkfb1 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis Ggps1 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) Shmt2 Tyms ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis Rrm2b Nme3 Nme2 Nme5 Nme4 Nme1 Nme7 Rrm1 Nme6 Rrm2 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde Nmnat1 Nmnat3 Nmnat2 Qprt Nadsyn1 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis Cox10 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I Rnmt Rngtt DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis Cbr1 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I Ptdss1 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) Elovl7 Fads2 Elovl2 Elovl5 Hsd17b12 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I Gale TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) B4galt1 B4galt2 B4galt3 St6gal1 B3gnt2 St8sia2 Gcnt3 Gcnt2 St3gal4 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III Aldh2 Aldh3a2 Cyp2e1 Acss2 Acss1 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II Aldh2 Aldh3a2 Acss2 Acss1 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation Bckdhb Bckdha Dbt Dld Mcee Pcca Pccb Mmut LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III Glb1 Lct Glb1l3 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV Aox1 Fmo3 Fmo2 Fmo5 Cyp2a5 Fmo4 Cyp4x1 Cyp2u1 Cyp2s1 Ugt1a5 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) Pgm1 Galt Galm Galk1 Pgm2 Gale UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II Gnpnat1 Uap1 Pgm3 Hk2 Gck Hk1 Gpi Gfpt1 Hk3 Gfpt2 Hkdc1 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis Gpt2 Gpt INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis Atic Adsl Paics L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) Dhtkd1 Aadat Aldh7a1 Aass L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis Sephs1 Sepsecs Sars2 Sars1 Pstk Sephs2 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation Phyh Acsm1 Aldh3a2 Hacl1 Slc27a2 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis Glul TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis Ggps1 Fdps THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis Mocos WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis Tyw1 Lcmt2 Tyw3 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I Napepld Plaat1 Gde1 Enpp2 Plaat5 Pla2g1b VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation Acat1 Acat2 Acsm1 Acadsb Echs1 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis Afmid Haao Nmnat1 Kmo Tdo2 Nmnat3 Kynu Nmnat2 Ido2 Qprt Ido1 Nadsyn1 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation Acsl1 Acsl3 Acsbg1 Slc27a2 Acsbg2 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) Tst 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis Dagla Plcb1 Daglb Ddhd1 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) Trmt112 Aqp9 Slc34a2 Aqp7 Slc2a1 Pnp Hemk2 Slc20a2 Slc20a1 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation Cyp2b10 Cyp2a5 Cyp4x1 Cyp2u1 Cyp2s1 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation Adh5 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I Pgm1 Ugp2 Pgm2 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis Ptgs2 Alox5 Lta4h ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis Aldh18a1 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation Papss2 Papss1 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis Gmppa Pmm2 Gpi Gmppb Mpi Pmm1 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Tm7sf2 Hsd17b7 Nsdhl Sqle Lbr Ebp Dhcr24 Sc5d Kcnh7 Dhcr7 Fdft1 Lss UREA CYCLE%BIOCYC%PWY-4984 urea cycle Otc Asl Cps1 Ass1 GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) Dmgdh Shmt2 Shmt1 Bhmt SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) Sqor Suox Tst HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis Alad Alas1 Alas2 Fech Hmbs Cpox Uros Urod Ppox PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I Mcee Pcca Pccb Mmut L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation Bckdhb Sds Bckdha Dbt Sdsl Dld GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage Pnp Hprt1 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle Nos3 Nos2 Nos1 Asl Ass1 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation Got1 Bckdhb Bckdha Cbs Dbt Cth Dld Bhmt Mcee Pcca Bhmt2 Mtr Pccb Mmut Suox Cdo1 Ahcy Mat2a Mat2b Mat1a TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis Alad Alas1 Alas2 Hmbs Uros MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway Acat1 Hmgcr Acat2 Mvd Hmgcs2 Idi1 Mvk Pmvk TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II Ppcs Fmo1 Ado ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) Gsto1 Glrx DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis Agpat1 Plpp4 Plpp2 Plpp3 Plpp1 Mogat1 Dgat2 Plppr4 Dgat1 Plppr2 Gpat4 Plppr3 Lpcat3 Gpat2 Gpat3 Lpcat4 Agpat5 Mboat7 Gpam Mboat1 Abhd5 Mboat2 Agpat3 Lclat1 Agpat4 Agpat2 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis Flad1 Rfk D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis Minpp1 Itpk1 Ipmk CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis Ddc Th Dbh Pnmt 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis Tyw1 Tyw3 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I Cdo1 Fmo1 Csad ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I Aprt MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle Got1 Mdh1 Mdh2 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor Bcar1 Fzr1 Ncoa1 Ap2b1 Arrb2 Fosb Cd44 Runx2 Kat2b Rb1 Mapk14 Tgfbr3 Prkar2a Pml Ski Map2k3 Mef2a Mef2c Brca1 Zfyve9 Rock1 E2f4 Tgfbr1 Cdkn1a E2f5 Tgfbr2 Atf2 Mapk8 Ccne1 Fkbp1a Stambpl1 Mapk1 Irf2bp1 Ctnnb1 Map3k7 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Vps39 Myc Cdc27 Akt1 Sox9 Cdc23 Skp1 Pdk1 Pard6a Dcp1a Rbx1 Prkcg Eid2 Prkcb Hgs Ube2d3 Prkcd Ube2d1 Nup153 Trp73 Btrc Cdc25a Atf3 Jund Sdc2 Pxn Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Ar Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Jun Cops5 Vdr Trp53 Ccnd1 Cav1 Sptbn1 Esr1 Ppp2r2a Ptk2 Stk11 Hspa8 Crebbp Smad2 Map4k1 Nup214 Smad3 Wwtr1 Sparc Smad4 Cdk6 Fnta Cdk4 Cdk2 Cul1 Cdc16 Cdk1 Tab1 Junb Daxx Smad6 Smad7 Hnf4a Rhoa Tgif1 Ing2 Xpo1 Xpo4 Ctcf Hdac1 Foxo4 Tfdp2 Tfdp1 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Pja1 Zeb1 Rbl2 Zeb2 Rbl1 Anapc10 Foxh1 Smurf2 Smurf1 Skil Pik3r1 Crk Pik3r2 Eng Lef1 Yap1 Stk11ip Hoxa9 Nfyb Eif3i Nfya Ppm1a Nfyc Prkar1b Ep300 Strap Map2k6 BDNF%IOB%BDNF BDNF Ptk2b Irs2 Elk1 Gsk3b Ntrk2 Ntrk1 Mapk3 Raf1 Akt1 Mapk9 Mapk8 Shc4 Mapk7 Shc1 Irs1 Mapk1 Foxo3 Plcg1 CCR1%IOB%CCR1 CCR1 Pxn Ptk2b Mapk3 Ccr1 Zap70 Creb3 Mapk14 Src Gna14 Rela Ccl7 Ccl5 Ccl4 Ccl3 Nfkb1 Stat1 Prkcd Ptk2 Mapk1 LEPTIN%IOB%LEPTIN Leptin Stat3 Grb2 Lepr Mapk3 Mapk14 Prkcd Irs1 Irs2 Sp1 Pik3r1 Pik3r2 Pde3a Itgav Socs7 Ncoa3 Ptpn11 Slc2a4 Jak3 Jak2 Egfr Ptk2 Khdrbs1 Itgb5 Mapk1 Lep Prkce THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin Stat3 Map2k1 Stat5b Atxn2l Mpl Mapk3 Gab1 Jak2 Shc1 Mapk1 Foxo3 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor Akt1 Mapk14 Prkcb Shc1 Plcg1 Gsk3b Raf1 Src Rela Stat1 Jun Ptpn11 Jak3 Jak2 Grb2 Stat5b Socs1 Mitf Socs5 Socs4 Matk Socs6 Crkl Ptpru Gys1 Cltc Sh3kbp1 Cblb Mad2l1 Fgr Hck Dok1 Wipf1 Rps6ka1 Tnfrsf10b Kit Prkca Spred1 Il7r Sos1 Spred2 Inpp5d Grb7 Rasa1 Was Eif4ebp1 Cbl Mtor Epor Csf2rb2 Abl1 Fyn Grap Lyn Kitlg Pik3r1 Yes1 Crk Pik3ca Pik3r2 Stat5a Tec Fes Hras Atf2 Mapk8 Ep300 Mapk1 CCR7%IOB%CCR7 CCR7 Ptk2b Foxo1 Gsk3b Mapk3 Mtor Mapk14 Akt1 Rela Cfl1 Ccr7 Adrb2 Mapk8 Mapk1 Foxo3 Plcg1 WNT%IOB%WNT Wnt Ctnnb1 Pi4k2a Map3k7 Rac1 Ppp1ca Nfatc2 Sfrp2 Arrb2 Ppp2ca Sfrp1 Daam1 Rspo1 Prkaca Akt1 Dkk1 Mesd Pax2 Gsk3a Frzb Dixdc1 Chd7 Axin1 Prkcg Ror1 Ror2 Prkcb Gckr Lrp1 Arhgef4 Prkcd Lrp6 Csnk1a1 Nlk Lrp5 Wnt3a Dvl1 Dvl2 Gpc3 Dvl3 Wnt7a Wnt2 Wnt1 Gsk3b Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd3 Fzd5 Jup Fzd4 Fzd7 Fzd6 Kremen1 Fzd9 Fzd8 Smad1 Bcl9 Apc Jun Pin1 Tcf4 Pip5k1b Ccnd1 Cdk6 Rhoa Prkca Yes1 Lef1 Ilk Mark2 Mapk8 Sox1 Wnt5a Ctbp1 Cdh1 Setdb1 Ywhab FAS%IOB%FAS Fas Bcl2 Rac1 Fas Pkn2 Pkn1 Vim Dffa Mapk3 Cdk11b Cdc27 Akt1 Rock1 Prkcd Csnk1a1 Gsk3b Traf3 Psme3 Faf1 Eif2ak2 Arhgdib Stk24 Map3k5 Xpo5 Parp1 Traf2 Traf1 Dedd2 Plec Csnk2b Map2k1 Prkn Parg Rfc1 Mst1 Bcl2l1 Xiap Glrx Casp8ap2 Eif3j2 Eif4b Gtf3c3 Lck Tcp1 Daxx Btk Anxa4 Fadd Top1 Met Csnk1e Cast Dedd Cd59b Max Srf Aifm1 Uso1 Ptpn6 Uba7 Stk4 Stk3 Prkdc Rasa1 Ripk2 Fasl Numa1 Hspb1 Cflar Eif2s1 Bid Pak2 Fyn Ube4b Casp8 Lyn Casp7 Tial1 Mbd4 Tia1 Casp9 Casp4 Casp3 Casp6 Fastk Satb1 Casp2 Casp1 Ripk1 Bmx Map2k2 Wee1 Diablo Mapk1 Pdcd6 Bax ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Rac1 Vim Erbb2 Clca1 Rpsa Ywhah Akt1 Ywhae Erbin Dsp Eif4e Lama5 Cd151 Itgb4 Lama2 Lama3 Mst1r Mylk3 Ywhaz Prkcd Pik3r3 Col17a1 Itga6 Trp73 Ntn1 Ephb2 Pak1 Shc1 Lamb2 Irs1 Lamb3 Pik3cg Sfn Irs2 Lamb1 Pik3cb Pik3cd Rtkn Bad Eif6 Lamc1 Ar Lamc2 Src Ptpn11 Egfr Ptk2 Smad2 Grb2 Plec Smad3 Rhoa Met Prkca Eif4ebp1 Mtor Abl1 Fyn Pik3r1 Yes1 Pik3ca Pik3r2 Casp3 Ywhab NGF%IOB%NGF NGF Elk1 Map2k1 Mapk3 Creb1 Dnaja3 Prkci Frs2 Mapk1 Sp1 HEDGEHOG%IOB%HEDGEHOG Hedgehog Ctnnb1 Sap18b Sufu Gas1 Kif27 Arrb2 Prkaca Ywhae Med23 Dhh Ihh Gli1 Gli3 Gli2 Shh Grk2 Ptch2 Ptch1 Dyrk1a Boc Med12 Med1 Hhip Stk36 Med6 Cdk8 Smo GM-CSF%IOB%GM-CSF GM-CSF Bcar1 Mapk3 Akt1 Mapk14 Tgfbr3 Gsk3a Map2k3 Mapk9 Shc1 Plcg1 Pxn Elk1 Gsk3b Bad Raf1 Creb1 Tgfb1 Stat1 Jak2 Stat3 Grb2 Map2k1 Ikbkb Stat5b Pdia3 Csf2ra Slc2a1 Gab1 Prdx3 Stam2 Syk Rack1 Vav1 Sptan1 Crkl Rps6ka2 Ezr Pfn1 Csf2 Ganab Stam Cct5 Dpysl2 Hck Ptprc Sh2b2 Nfkbia Bcl3 Hnrnph1 Park7 Prkca Chuk Ptpn6 Cbl Csf2rb2 Lyn Pik3r1 Yes1 Pik3r2 Stat5a Fes Mapk8 Map2k2 Mapk1 Map2k6 CCR9%IOB%CCR9 CCR9 Cd226 Foxo1 Itgb7 Ccl25 Gsk3b Itga4 Ccr9 Mapk3 Mapk14 Akt1 Ezr Mapk8 Rdx Cdh1 Madcam1 Mapk1 Msn TIE1 TEK%IOB%TIE1 TEK TIE1 TEK Grb7 Elk1 Map2k1 Stat5b Nos3 Tie1 Mapk3 Raf1 Dok2 Tek Nck1 Mapk14 Akt1 Stat5a Fes Bmx Map2k2 Ptk2 Pak1 Shc1 Mapk1 CCR5%IOB%CCR5 CCR5 Stat3 Grb2 Ikbkb Mapk3 Akt1 Mapk14 Syk Nfkbia Chuk Ptpn6 Ptk2b Psma5 C5ar1 Afp Rela Ccl11 Ccl7 Cd4 Ccl5 Ccl12 Ccl4 Pik3r1 Ccl2 Ccr5 Stat5a Stat1 Cfl1 Mapk1 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha Stat3 Stat5b Akt1 Vav1 Eif4b Crkl Map2k3 Prkcd Nfkbia Irs1 Foxo1 Irs2 Eif4ebp1 Cbl Mtor Zap70 Crk Stat5a Stat6 Stat1 Stat4 Erbb3 Pla2g4a Ifnar1 Ifnar2 Jak1 Arhgap30 Tyk2 Prkcq Map2k4 Rps6ka5 Stat2 Map2k6 TRAIL%IOB%TRAIL TRAIL H2ax Ctnnb1 Dap3 Map3k7 Bex3 Chek2 Ikbkg Tnfrsf11b Mapk3 Prkaa1 Tradd Bak1 Bcl10 Xiap Akt1 Mcl1 Mapk14 Vdac1 Tnfsf10 Apaf1 Irf5 Atm Fadd Nfkbia Tnfrsf10b Aifm1 Prkdc Cbl Cflar Bid Creb1 Src Casp8 Rela Casp7 Nfkb1 Casp3 Casp2 Casp1 Ripk1 Diablo Mapk1 Parp1 Ctsb Traf2 Bax NOTCH%IOB%NOTCH Notch Mapk3 Kat2b Skp1 App Sin3a Rbx1 Fhl1 Hivep3 Hdac2 Mfng Hey1 Numb Ccn3 Skp2 Sap30 Hes6 Tle1 Maml3 Notch4 Fbxw7 Notch1 Notch2 Notch3 Gsk3b Psen1 Pofut1 Psen2 Ncor1 Spen Ncstn Aph1b Ncor2 Dtx1 Rela Dll1 Dll3 Dll4 Itch Maml1 Smad1 Nfkb1 Ring1 Maml2 Hes1 Furin Jag2 Jag1 Cirsr Rbpj Yy1 Jak2 Lfng Tcf3 Stat3 Smad3 Smad4 Cul1 Hdac1 Lef1 Ep300 Mapk1 M-CSF%IOB%M-CSF M-CSF Grap2 Stat3 Tfe3 Grb2 Gab3 Pstpip2 Dnm1 Stat5b Vim Csf1 Mitf Akt1 Fadd Prkcd Shc1 Ptk2b Inpp5d Cbl Casp8 Pik3r1 Stat5a Ptpn11 Ripk1 Ets2 Ptk2 Csf1r Myo18a Inppl1 EGFR1%IOB%EGFR1 EGFR1 Mapk8 Mapk1 Mapk3 Myc Akt1 Prkcg Prkcb Hgs Prkcd Jund Pxn Dab2 Sp1 Jun Trp53 Cav1 Ptk2 Stk11 Smad2 Smad3 Cdk2 Cdk1 Rhoa Tgif1 Hdac1 Zfyve16 Foxo1 Fos Pik3r1 Crk Pik3r2 Bcar1 Ap2b1 Mapk14 Map2k3 Mapk9 Mapk7 Shc1 Plcg1 Ptk2b Irs2 Elk1 Gsk3b Raf1 Src Rela Nfkb1 Stat1 Ptpn11 Jak2 Egfr Khdrbs1 Stat3 Grb2 Map2k1 Stat5b Gab1 Socs1 Crkl Cltc Sh3kbp1 Cblb Dok1 Rps6ka1 Kit Prkca Sos1 Grb7 Rasa1 Eif4ebp1 Cbl Mtor Abl1 Fyn Lyn Pik3ca Stat5a Hras Cfl1 Ctbp1 Cdh1 Ywhab Rac1 Gsk3a Arhgef4 Jup Plec Lck Anxa4 Met Cd59b Ptpn6 Casp9 Ripk1 Map2k2 Bcl2 Pkn2 Vim Erbb2 Erbin Dsp Itgb4 Ywhaz Pik3r3 Col17a1 Ephb2 Pak1 Pik3cg Pik3cb Pik3cd Bad Creb1 Prkci Frs2 Grk2 Dyrk1a Stam2 Vav1 Rps6ka2 Pfn1 Stam Nos3 Dok2 Nck1 Erbb3 Jak1 Tyk2 Rps6ka5 Stat2 Prkaa1 App Itch Inppl1 Dnm1 Myl12b Il17rd Pard3 Mprip Prkd1 Elk4 Eps8 Gja1 Tfg Ralb Otud6b Araf Plcg2 Arhgap5 Itsn2 Arap1 S100a14 Zdhhc5 S100a10 S100a11 Snca Trip6 Flot2 Flot1 Errfi1 Myo6 Scrib Prkcz Tfrc Garem1 Pik3c2b mt-Co2 Antxr1 Arf4 Braf Shb Clta Pgam1 Cyld Ldha Ahnak Snx33 Tkt Baiap2l1 Prkar1a Rbck1 Htt Appl1 Appl2 EG433182 Caskin2 Stx4 Pygb Gsn Pdzd11 Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Abi1 Ensa Frk Hipk2 Map3k14 Hipk3 Marveld2 Eef1a2 Socs3 Atxn2 Grb14 Grb10 Phpt1 Stip1 Map3k4 Pias3 Cdh3 Cdh2 Plekhn1 Eps15 Map3k3 Magi1 Map3k2 Map3k1 Hat1 Pkp2 Hnrnpdl Ldlr Pkp4 Pkp3 Flnb Anxa2 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Abl2 Serpinb3d Slc38a2 Ptpre Tnk2 Ptpra Cdk5 Alb Pdlim1 Sh3bgrl Pdlim4 Nck2 Slc12a7 Acp1 Sh3gl3 Adam9 Epha1 Epha2 Epha4 Itgb1 Pkm Dsg2 Sh3gl2 Sos2 Ctnnal1 Ubash3b Wbp2 Atp1a1 Sri Ephb1 Cebpb Cebpa Ephb3 Ephb4 Ahcyl1 Hnrnpa1 Ptpn1 Slitrk6 Csk Arhgap32 Arhgap35 Rbbp7 Tagln2 Pten Sh2b1 Ralbp1 Bcar3 Slc25a5 Spart Nectin1 Rps10 Ppp2r3a Prkaa2 Scamp3 Tns4 Tns3 Tns2 Tns1 Krt8 Cblc Krt7 Krt5 Phlpp1 Actb Actr2 Actr3 Rin1 Tln1 Vasp Arhgef7 H3c8 Hnrnpr Sdc4 Sdc3 Insr Atp5f1c Usp6nl Pttg1ip Slc5a5 Snx5 Tollip Ptk6 Pdcd6ip Kirrel1 Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Dyrk1b Ptprk Dcbld2 Ptprf Git1 Rps27l Vav3 Laptm4a Cdv3 Plekha6 Plekha5 Vav2 Mink1 Actn1 Prpf4b Actn4 Plscr1 Gprc5a Aldoa Map2k7 Map2k5 Limd1 Cstb Git2 Krt18 Krt17 Racgap1 Wasl Cttn Mpzl1 Axl Ctnnd1 Nedd9 Huwe1 Tjp2 Cavin1 Cavin2 Sdcbp Cc2d1a Prkx Krt6a Ap2a1 Vcl Cysrt1 Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Tom1l1 Efnb2 Cav2 Sirpa Ralgds Dlg3 Crim1 Ddx6 Peak1 Afap1l2 Ddx3x Sfpq Pdpk1 Dapp1 Iqgap1 Asap1 Anks1 Asap3 Baiap2 Lsr Epn2 Epn1 Dyrk4 Rps6ka3 Epn3 Dock4 Usp31 Dyrk3 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Eif4g1 Dock1 Phldb2 Ptpn18 Rgs16 Ptpn12 Mta2 Egf Spry2 Spry3 Spry1 Reps2 Prag1 Spry4 Pebp1 Ptpn23 Zpr1 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor Cdc25b Nono Trim68 Ncoa1 Bag1 Gtf2h1 Psmc3ip Rbak Cdk11b Ccnd3 Runx2 Nelfcd Kat2b Pelp1 Rb1 Cdk9 Xrcc6 Cdk7 Hspa5 Xrcc5 Mdm2 Fhl2 Pias3 Pou2f1 Prmt1 Brca1 Rac3 Rnf14 Calr Nr0b2 Spdef Etv5 Efcab6 Lpxn Svil Ddc Il6st Tmf1 Arnt Hsp90b1 Zmiz2 Zmiz1 Gsk3b Rnf4 Foxa1 Magea13 Ncoa2 Ncoa6 Nsd2 Nsd1 Src Pnrc1 Pak6 Rela Stub1 Tgfb1i1 Slc25a4 Vip Rchy1 Ran Ncoa3 Egfr Stat3 Cebpa Rack1 Pten Park7 Ccne1 Ctnnb1 Ppp1ca Akt1 Sin3a Cdc25a Pxn Ar Ncor2 Sp1 Jun Tcf4 Ccnd1 Cav1 Esr1 Hspa8 Parp1 Smad3 Smad4 Prkd1 Daxx Top1 Tgif1 Hdac1 Hspb1 Brinp1 Nr2c2 Nr2c1 Nrip1 Ahr Hsp90aa1 Casp8 Uxt Casp7 Pias4 Kat5 Pik3r1 Ube2i Kat7 Gtf2f2 Gtf2f1 Casp3 Pias1 Sf1 Appl1 Ccnh Prdx1 Tle5 Casp1 Patz1 Dapk3 Flna Gsn Cdc37 Pa2g4 Ep300 Ranbp9 Senp1 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 Stat3 Cbl Mapk3 Gab1 Cebpa Creb1 Akt1 Lyn Stat5a Flt3 Jun Cblb Gab2 Atf2 Mapk1 CD40%IOB%CD40 CD40 Stat3 Map2k1 Ikbkb Mapk3 Myc Mapk14 Syk Akt1 Fyn Lyn Lck Pik3r1 Plcg2 Jun Fgr Nfkbia Jak3 Mapk9 Mapk8 Chuk Mapk1 TNFSF3%IOB%TNFSF3 TNFSF3 Rela Nfkb1 Jun Traf5 Relb Traf3 Tnfrsf1b Tnfrsf1a Nfkbia Nfkb2 Lta Ltb Ltbr Traf2 ID%IOB%ID ID Id2 Id1 Elk1 Id4 Smad3 Id3 Myf5 Tcf7l2 Rbl2 Rb1 Rbl1 Cdk2 Elk4 Hes1 Tcf3 Myod1 Psmd4 Atf3 Pax5 Elk3 G-CSF%IOB%G-CSF G-CSF Stat3 Grb2 Stat5b Il3ra Mapk3 Csf3r Pom121 Fth1 Pla2g1b Socs3 Akt1 Mapk14 Syk Syp Cdk2 Rel Cish Cdkn1b Csf3 Lck Hck Csnk1e Rps6ka1 Shc1 Inpp5d Cbl Prkci Lyn Stat5a Stat1 Gab2 Ptpn11 Jak1 Jak2 Tyk2 Mapk1 EPO%IOB%EPO EPO Stat3 Map2k1 Stat5b Mapk3 Gab1 Akt1 Syk Vav1 Gsk3a Crkl H2bc7 Hcls1 Sgk1 Sh2b2 Foxo4 Foxo3 Foxo1 Irs2 Bad Nos3 Raf1 Mtor Braf Epor Stat5a Jun Ptpn11 Jak2 Map2k2 Rps6ka5 Mapk1 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma Stat3 Cebpb Mapk3 Akt1 Mapk14 Crkl Spi1 Plcg2 Ifngr1 Hoxa10 Irf1 Irf2 Irf8 Mapk11 Cbl Raf1 Crk Stat5a Stat6 Stat1 Pla2g4a Jak1 Mapk8 Jak2 Prkcq Egfr Mapk1 TNFSF1%IOB%TNFSF1 TNFSF1 Ikbkg Akt1 Rela Nfkb1 Jun Traf5 Relb Traf3 Tnfrsf1b Tnfrsf1a Nfkbia Nfkb2 Tnfrsf14 Lta Ltbr TNFALPHA%IOB%TNFALPHA TNFalpha Pkn1 Map3k14 Rb1 Cdk9 Ywhah Mapk14 Ywhae Pml Map3k3 Ywhaz Map3k2 Map3k1 Mapk9 Creb1 Src Rela Nfkb1 Stat1 Traf5 Relb Tnfrsf1b Tnfrsf1a Ptpn11 Nfkb2 Egfr Ikbkb Gab1 Syk Rel Rack1 Dok1 Nfkbia Bcl3 Rpl4 Nkiras1 Nkiras2 Chuk Tbkbp1 Trib3 Map3k8 Nlrp4e Rps11 Tnf Fbl Unc5cl Tbk1 Tnfrsf11a Akt2 Dpf2 Kcnq1 Azi2 Polr1b Ppp1r13l Polr1c Polr1a Usp2 Polr1d Polr1e Stat5a Fbxw11 Txlna Tank Gtf2i Hsp90ab1 Actl6a Smarce1 Tifa Mark2 Mapk8 Cdc34 Rasa3 Nfkbiz Papola Rps6ka5 Mapk1 Glg1 Bag4 Ywhab Sec16a Map3k7 Ripk3 Cradd G3bp2 Dcaf7 Ikbkg Cops3 Mapk3 Nfkbib Nfkbie Tradd Kpna6 Kpna3 Akt1 Ccnt1 Tab3 Tab2 Skp1 Traf7 Traf4 Pfdn2 Traf6 Birc2 Tnfrsf8 Ikbke Ywhag Hdac2 Psmd12 Ube2d3 Copb2 Map2k5 Prkcd Smarcb1 Psmd13 Alpl Rasal2 Btrc Akap8 Hdac6 Iqgap2 Psmb5 Peg3 Fbxw7 Bcl7a Ppp6c Nupr1 Fkbp5 Smarca4 Mcm5 Tnip2 Psmc2 Psmc1 Psmc3 Polr2h Pdcd2 Nsmaf Zfand5 Commd1 Trpc4ap Psmd7 Psmd6 Mapkapk2 Jun Fancd2 Cops5 Psmd3 Psmd2 Traf3 Elp1 Psmd1 Cav1 Faf1 Ktn1 Spag9 Usp11 Glb1 Smarcc2 Prc1 Ddx3x Smarcc1 Crebbp Traf2 Rnf25 Traf1 Map3k11 Tnfaip3 Lrpprc Mtif2 Cul1 Tab1 Fadd Hdac1 Prkcz Hspb1 Brinp1 Cflar Nr2c2 Bid Hsp90aa1 Casp8 Casp7 Ube2i Casp3 Casp2 Ripk1 Flna Cdc37 Map2k6 GDNF%IOB%GDNF GDNF Pxn Ptk2b Bcar1 Map2k1 Ret Th Raf1 Cdc25c Gab1 Rps6ka3 Fyn Cdk1 Crk Jun Met Dok1 Nfkbia Map2k2 Ptk2 TNFSF8%IOB%TNFSF8 TNFSF8 Traf1 Nfkb1 Tnfrsf8 Relb Traf3 Nfkb2 Bcl3 Akt1 Rel Rela Mapk1 CXCR4%IOB%CXCR4 CXCR4 Bcar1 Rac1 Arrb2 Mapk3 Vav2 Map2k3 Prkcd Plcg1 Pxn Ptk2b Elk1 Gsk3b Bad Zap70 Creb1 Src Rela Nfkb1 Stat1 Ptpn11 Jak3 Jak2 Egfr Ptk2 Hspa8 Stat3 Map2k1 Ikbkb Stat5b Itk Cxcr4 Itgb2 Icam1 Gnai1 Vav1 Tff2 Lcp2 Crkl Rps6ka2 Cxcl12 Lck Gna13 Grk6 Fyb1 Plcg2 Ackr3 Cblb Esr2 Rhoa Vcam1 Limk1 Ptprc Usp14 Dok1 Nfkbia Chuk Foxo3 Ptpn6 Inpp5d Rasa1 Was Cbl Nck1 Fyn Lyn Pik3r1 Crk Sdc4 Ccr5 Pik3r2 Stat4 Cfl1 Map2k2 Mapk1 Stat2 Ywhab CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway Fosl1 Jun Chp1 Rcan2 Fkbp1a Il2ra Prkaca Fos Batf3 Il2 Il4 Cabin1 Pou2f1 Ifng Fasl Cd40lg Akap5 Nfatc1 Csf2 Junb Nfatc3 Ptgs2 Nfatc2 Rcan1 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling Jun Fos Atf2 Il10 Sin3a Sin3b Hnf4a Nkx2-5 Pias3 Tgif1 Hdac2 Pias4 Tgif2 Ifnb1 Ctbp1 Myc Hdac1 Foxg1 Akt1 Foxo4 Cdkn2b Tfdp1 Foxo3 Foxo1 Creb1 Sap30 Col1a2 Tfe3 Dcp1a Rbl1 Itgb5 Sap18b Foxh1 Irf7 Gata3 Serpine1 Skil Med15 Atf3 Ncor1 Dlx1 Nr3c1 Myod1 Max Ep300 Snip1 Cebpb Ar Ncoa2 Ncoa1 Il5 Sp1 Gsc Cited1 Sp3 Runx3 Runx2 Kat2b Kat2a Cbfb Vdr Rbbp4 Rbbp7 Esr1 Hspa8 Crebbp Ski Smad2 Smad3 Mef2c Smad4 Zbtb17 Cdk4 Cdk2 Lamc1 E2f4 Tcf3 Cdkn1a E2f5 Smad7 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events Nfkbia Stat5a Il18r1 Il1b Stat3 Stat1 Pik3r1 Alox12b Il2 Ifng Socs3 Stat4 Il12b Il18 Il18rap Il19 Cd3e Tnf Mpo Il6 Cd4 Ccl12 Cxcl9 Itga3 Il23r Nfkb1 Cxcl3 Jak2 Il12rb1 Pik3ca Tyk2 Nos2 Il24 Il17f Il23a Rela Il17a SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression Hdac1 Ranbp2 Hdac4 Ube2i Mdm2 Pias1 Ran Pias2 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events Nfkbia Jun Pik3r1 Fos Mapk8 Mapk1 Ilk Itgav Mapk3 Rhoa Bcar1 Spp1 Rac1 Cd44 Vav3 Gsn Syk Mmp2 Ptk2b Mmp9 Map3k1 Plau Itgb3 Rock2 Chuk Pip5k1a Map3k14 Nfkb1 Pik3ca Rela ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events Fkbp1a Mapk1 Mapk3 Smad4 Smad7 Tgfb1 Tgfb3 Acvrl1 Id1 Arrb2 Ppp1ca Csnk2b Cav1 Gdf2 Bmpr2 Smad1 Acvr1 Tlx2 Smad9 Acvr2a Inhba Acvr2b Smad5 Tgfbr1 Tgfbr2 Eng SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase Rasa1 Irs1 Jun Pxn Irs2 Grb10 Gdnf Ptpn11 Prkaca Pik3r1 Gfra1 Nck1 Rap1a Gab1 Frs2 Ptk2 Dok1 Dok4 Mapk8 Dok5 Mapk1 Dok6 Grb2 Prkca Mapk3 Sos1 Rhoa Crk Bcar1 Hras Rac1 Creb1 Pik3ca Ret Grb7 Shank3 Shc1 Src SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events Prkaca Mapk1 Mapk3 Fgf15 Col11a1 Col11a2 Cask Ccl5 Bsg Hpse Ppib Col2a1 Mmp9 Sdcbp Col3a1 Mmp7 Col1a1 Col6a1 Col5a2 Col4a3 Tgfb1 Col4a4 Col7a1 Col6a2 Hgf Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Col1a2 Fgf23 Fgfr3 Fgfr4 Mmp1a Lama5 Sdc1 Met REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation Rasa1 Plce1 Lgals1 Lgals3 Rasgrf1 Rasgrf2 Nras Prkcb Rras Prkce Rasgrp3 Rasgrp4 Rasgrp1 Rasgrp2 Rin1 Sos2 Grb2 Prkca Sos1 Hras Rasa2 Rasa4 Rabgef1 Camk2b Rasal1 Nf1 Dab2ip Kras Prkcz Syngap1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling Aurkb Incenp IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events Stat5a Pik3r1 Il4 Cd40lg Socs1 Spi1 Stat6 Alox15 Ets1 Socs5 Myb Il10 Jak3 Aicda Jak1 Il13ra1 Il13ra2 Arg1 Bcl2l1 Fcer2a Mybl1 Dok2 Itgb3 Irf4 Lta Oprm1 Tff3 Inpp5d Akt1 Ptpn6 Thy1 Ccl17 Cbl Mtor Selp Ccl11 Gtf3a Col1a2 Pigr Mapk14 Egr2 Parp14 Il2rg Stat5b Bcl6 Fes Il4ra Hmga1 Retnlg Shc1 Irs1 Irs2 Cebpb Il5 Sp1 Grb2 Col1a1 Socs3 Jak2 Pik3ca IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K Tert Lck Bcl2 E2f1 Ugcg Il2ra Ptpn11 Pik3r1 Il2 Grb2 Sos1 Myb Rac1 Jak3 Jak1 Bcl2l1 Myc Akt1 Mtor Foxo3 Il2rg Nfkb1 Pik3ca Smpd1 Il2rb Eif3a Hsp90aa1 Shc1 Sgms1 Prkcz Rela Gab2 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling Il2ra Nras Stat1 Prkaca Pik3r1 Il2 Ifng Rhoa Jak3 Jak1 Il2rg Il2rb Shc1 Gab2 Irs1 Lck Bdnf Afdn Ptpn11 Kdr Angpt1 Lmo4 Gab1 Ngf Frs2 Frs3 Egfr Gnai1 Raf1 Gnai3 Il6st Sdc2 Grb2 Ntf4 Sos1 Ntf3 Pdgfrb Ifngr1 Hras Vegfa Pdgfb Pag1 Arhgap35 Nos3 Egf Igf1 Ntrk2 Map2k2 Ntrk1 Map2k1 Il6ra Ntrk3 Tek Igf1r Il6 Jak2 Pik3ca Kras NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network Gata1 Ep300 Cdkn1b E2f1 Ar Stat3 Ncoa1 Kdr Runx2 Crebbp Myb Tcf3 Ctbp1 Spen Hdac1 Neurog3 Ncor2 Arnt Ptf1a Camk2d Ghr Hif1a Maml1 Hey2 Cd4 Maml2 Hey1 Parp1 Hes1 Twist1 Ascl1 Rb1 Jak2 Hes6 Tle1 Gaa Rbbp8 Kdm1a Rbpj Ncor1 Yy1 Notch1 Gata6 Rcan1 Myod1 Gata4 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions Itga7 Itga8 Itgax Itga5 Itga6 Itga9 Itgam Itga4 Itga1 Itga2 Itgae Itgal Itga10 Itga11 Itgad Itgb8 Itgav Itgb6 Itgb7 Itgb1 Itga2b Itgb4 Itgb2 Itgb3 Itga3 Itgb5 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events Incenp Rhoa Golga2 Nudc Bora Kif2a Kif20a Fbxo5 Spc24 Ercc6l Ppp1r12a Fzr1 Pak1 Rock2 Ect2 Tubg1 Bub1 Cdc14b Cdc20 Ppp1cb Ppp2ca Plk1 Gorasp1 Clspn Fbxw11 Stag2 Cenpu Tpx2 Sgo1 Rab1a Wee1 Ppp2r1a Prc1 Cdk1 Bub1b Btrc Ninl Kiz Cdc25c Aurka Cenpe Cdc25b Ndc80 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events Ccne1 Cstf1 Bard1 Prkdc Fancl Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad51 Rad50 Pcna Fancd2 Ewsr1 Trp53 Topbp1 Xrcc6 Brca1 Ube2d3 Xrcc5 Atm Ube2l3 Cdk2 Rbbp8 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway Rhoa Gna12 Gnaz Gnao1 Gnai2 Gnai1 S1pr5 Gnai3 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma Stat5a Nras Pik3r1 Gab1 Ngf Grb2 Sos1 Hras Camk4 Ywhah Ntrk1 Ywhag Ywhae Pdpk1 Camk2a Ywhab Trpc3 Trpv1 Akt1 Agap2 Sfn Egr1 Bad Foxo3 Ccnd1 Plcg1 Creb1 Gsk3b Prkcd Ywhaz Pik3ca Kras Shc1 Src IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 Jun Il18r1 Stat3 Il2ra Fos Il2 Ifng Pias2 Mapk8 Crebbp Stat4 Tgfb1 Il18 Il18rap Cd3e Cd4 Mapk9 H2-Eb1 Il13 Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Tbx21 Etv5 Irf1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling Rasa1 Klhl9 Kif2c Ppp2r5d Smc4 Smc2 Birc5 Evi5 Ncaph Ppp1cc Npm1 Cbx5 Cdca8 Racgap1 Ncapd2 Septin1 Incenp Tacc1 Mylk Aurkb Des Nsun2 Pebp1 Rhoa Klhl13 Cul3 Vim Kif23 Kif20a Bub1 Sgo1 Aurka Psma3 Cenpa Stmn1 Ndc80 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events Pik3r1 Nck1 Ptk2 Mapk1 Mapk3 Rhoa Bcar1 Rac1 Ntn1 Dock1 Elmo1 Fyn Yes1 Trio Dcc Map2k2 Map1b Wasl Map2k1 Dapk1 Pak1 Unc5b Camk2a Myo10 Unc5a Unc5c Agap2 Plcg1 Pik3ca Src S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway Gna13 S1pr4 Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Rhoa Gna12 Gnaz Gnao1 Gnai2 S1pr5 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events Map2k1 Mapk1 Pde3b Pik3cg Pik3r6 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network Gata1 Cdkn1b Nras Ube2i Spi1 Ets1 Ptgs2 Myb Sin3a Pias3 Myc Adora2b Ccna1 Slc25a3 Birc3 Prtn3 Col1a2 Map3k7 Ets2 Clta Tfec Pim1 Iqgap1 Cdkn2a Rag2 Gata3 Ppid Atp2b1 Pax5 Zfpm1 Snd1 Ncor1 Maf Ptcra Kit Myod1 Smarca2 Mcm4 Ep300 Cd34 Bcl2 Lef1 Cebpb Mat2a Trim28 Cebpd Nlk Cebpa Sp1 Elane Csf1r Gstm2 Yeats4 Copa Wnt1 H2az1 Ppp3ca Kitlg Cbx4 Casp6 Anpep Mad1l1 Hspa8 Hras Crebbp Ca1 Ski Zfhx3 Cdk6 Lect2 Myf6 Tab2 Tab1 Hipk2 Ada Cdkn1a Ccnd1 Mpo Cd4 Hes1 Kras EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling Rasa1 Pxn Nras Pik3r1 Rras Nck1 Rap1a Ptk2 Mapk1 Grb2 Mapk3 Crk Hras Rac1 Ephb1 Ephb2 Wasl Map2k1 Ephb3 Map4k4 Pak1 Ephb4 Tf Efnb1 Efnb2 Efnb3 Rap1b Synj1 Dnm1 Itsn1 Rock1 Kalrn Efna5 Pik3ca Grb7 Kras Shc1 Src FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway Ezr Mapk10 Mapk11 Pik3r1 Fasl Mapk8 Syk Map3k1 Pdpk1 Chuk Akt1 Birc3 Ikbkb Mapk9 Birc2 Mapk14 Ikbkg Map2k7 Map2k6 Cltc Cflar Faim2 Pik3cb Bid Pik3ca Casp8 Smpd1 Rfc1 Casp3 Ripk1 Btk Fas Src Fadd PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events Plk4 Plk2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway Nfkbia Bcl2 Smpd3 Ctsd Aifm1 Eif2ak2 Pawr Nsmaf Madd Asah1 Tnfrsf1a Bag4 Raf1 Mapk8 Tradd Mapk1 Cradd Pdgfa Traf2 Mapk3 Ksr1 Prkra Eif2a Map2k4 Sphk2 Bax Egf Igf1 Map2k2 Map3k1 Map2k1 Map4k4 Myc Akt1 Bad Tnf Birc3 Prkcd Nfkb1 Rb1 Bid Casp8 Smpd1 Ripk1 Prkcz Rela Fadd ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling Lck Ppp2r5d Fkbp1a Ube2l3 Blk Pld1 Plcb2 Fyn Syk Klk6 Yes1 Pld2 Ptk2b Grk5 Th Tor1a Sncaip Slc6a3 Lyn Prkn Uchl1 Maob Stub1 Fgr Hck Bad Park7 Snca Prkcd Src ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway Nfkbia Lck Pik3r1 Arrb2 Bcl3 Rel Ikbkb Mapk14 Nfkb1 Pik3ca Btrc Syk Rela Src RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway Pkn2 Ezr Jun Pkn1 Cdkn1b Sh3gl2 Tln1 Pip5k1c Pip5k1b F2rl2 Fos Vcl Scai Mapk8 Rhoa Itgb1 Map2k4 Atf2 Pld1 Pld2 Ppp1r12a Rock2 Pip5k1a Rock1 Srf Ccn1 Slc9a1 Acta1 Mapk12 Map2k6 Pard6a Diaph1 Slc9a3 Rdx Cfl1 Msn Pten Cit Map2k3 Myl2 Limk1 Prkcz Limk2 Mrtfa SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B Stat5a Stat3 Pik3r1 Rhoa Itga2b Bcar1 Blk Fyn Yes1 Itgb3 Lyn Akt1 Fgr Hck Cav1 Stat5b Shc1 Src Irs1 Lck Ins2 Prl Csf1r Ybx1 Prlr Egfr Cdh2 Dok1 Fcgr3 Csn2 Csf1 Insr Grb2 Trpv6 Txn Crk Ptpn1 Pdgfrb Csk Capn1 Pdgfb Spry2 Fer Lep Nox4 Egf Lat Lepr Socs3 Jak2 Pik3ca Tyk2 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events Rasa1 Ezr Prkaca Itga2 Mapk8 Mapk1 Sdc2 Csf2 Mapk3 Rhoa Itgb1 Hras Fgf15 Bax Cask Mmp2 Fn1 Kng2 Tnfrsf13b Sdcbp Ephb2 Cav2 Trappc4 Rack1 Epb41 Lama1 Lama3 Tgfb1 Prkcd Fgf23 Fgfr3 Fgfr4 Nf1 Casp3 Src RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway Map2k1 Nras Ptpn7 Prkcb Braf Fos Map3k8 Elk1 Raf1 Mapk1 Prkca Mapk3 Hras Kras ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network Jun Mapk11 Fos Pou2f1 Ifng Mapk8 Mapk1 Mapk3 Junb Cul3 Atf2 Mmp2 Arg1 Bcl2l1 Th Plau Creb1 Mapk14 Atf3 Ep300 Bcl2 Ins2 Cbfb Prkca Esr1 Brca1 Cdk4 Socs3 Hrk Ccna2 Ccnd1 Hbb-bh1 Serpinb5 Kat5 Il6 Ache Mapk9 Macroh2a1 Ddit3 Col24a1 Hes1 Jdp2 Ruvbl2 Csrp2 Rb1 Jund Gadd45a Sele Dusp5 Tgfb2 Nos2 Dusp1 Nf1 Pdgfra Il23a Dusp10 Dusp8 Ppargc1a EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling Efna1 Efna2 Lck Efna3 Arhgef15 Crkl Ngef Epha1 Epha2 Epha3 Vav2 Epha4 Epha5 Epha6 Epha7 Cdk5 Epha8 Rhoa Crk Blk Vav3 Fyn Yes1 Lyn Fgr Pik3cg Hck Cbl Pik3r6 Plcg1 Rock1 Efna5 Src SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I Gata1 Nfkbia Stat3 Prkaca Ranbp2 Hdac4 Ube2i Tnfrsf1a Ran Nr2c1 Smg5 Prmt5 Hdac3 Hdac5 Hdac7 Hdac6 Hdac9 Hdac8 Sin3a Fkbp3 Sin3b Pparg Chd3 Chd4 Sirt3 Sirt2 Hdac2 Sirt1 Smurf1 Wdr77 Sirt7 Gata2 Sirt6 Hdac1 Sirt5 Sirt4 Hdac11 Hdac10 Mta2 Tfcp2 Mbd3 Mbd2 Gatad2a Sap30 Mxd1 Gatad2b Sap18b Btrc Zfpm1 Ncor1 Max Ep300 Kat2b Rbbp4 Rbbp7 Crebbp Smad7 Ncor2 Tnf Nfkb1 Yy1 Rela ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events Vamp3 Exoc1 Itga7 Nme1 Itga8 Exoc2 Dnm2 Pip5k1c Itga5 Spag9 Itga6 Avpr2 Itga9 Exoc7 Bin1 Ins2 Itga4 Ctnnd1 Itga1 Mapk8ip3 Itga2 Cpe Arf6 Itga10 Itga11 Itgav Itgb1 Pld1 Pld2 Ctnnb1 Klc1 Tshr Itga3 Cdh1 Asap2 Cltc Agtr1a Slc2a4 Adrb2 Scamp2 Acap1 Rala Exoc3 Exoc4 Ctnna1 Exoc5 Exoc6 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling Ep300 Cdkn1b Mapk10 Csnk1a1 Ran Csnk1g3 Fasl Kat2b Mapk8 Csnk1g1 Bcl2l11 Csnk1g2 Zfand5 Skp2 Fbxo32 Ralb Mst1 Crebbp Sod2 Usp7 G6pc1 Rbl2 Cat Csnk1d Sgk1 Cdk2 Csnk1e Ywhah Sirt1 Ywhag Ywhae Chuk Ywhab Akt1 Foxo4 Sfn Plk1 Foxo3 Foxo1 Ikbkb Ywhaz Mapk9 Ctnnb1 Bcl6 Gadd45a Rala SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway Sgpl1 Gna15 Gna14 Abcc1 Gnaq Sphk1 Gna13 S1pr1 S1pr3 S1pr4 S1pr2 Sgpp1 Gnai1 Gnai3 Sphk2 Gna12 Gnaz Gnao1 Gnai2 S1pr5 Gna11 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt Cdkn1b Prkdc Prkaca Raf1 Bcl2l1 Ywhah Ywhag Ywhae Pdpk1 Cdkn1a Chuk Ywhab Akt1 Foxo4 Sfn Rictor Bad Mtor Map3k5 Foxo3 Akt3 Foxo1 Akt2 Gsk3b Casp9 Tbc1d4 Ywhaz Kpna1 Mapkap1 Gsk3a Mlst8 Slc2a4 Hsp90aa1 Src E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction Nme1 Pip5k1c Afdn Pik3r1 Rap1a Vav2 Ctnnd1 Itgae Arf6 Itgb7 Rhoa Crk Rac1 Akt1 Rap1b Ccnd1 Ctnnb1 Cdh1 Tiam1 Nckap1 Iqgap1 Klhl20 Ap1m1 Wasf2 Pik3ca Jup Cttn Tjp1 Dlg1 Ctnna1 Rapgef1 Cyfip2 Src Abi1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family Stil Dhh Hhip Ihh Lrp2 Gli2 Hhat Pik3r1 Shh Akt1 Grk2 Lrpap1 Smo Arrb2 Ptch2 Ptch1 Boc Gas1 Pthlh Cdon Pik3ca Tgfb2 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle Plk3 Plk4 Plk2 Plk1 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway Jun Stat5a Stat3 Racgap1 Mapk8 Ncf1 Ncf2 Brk1 Arhgdia Bcar1 Noxa1 Map2k4 Atf2 Rac1 Baiap2 Iqgap3 Arpc1b Actr2 Plcb2 Actr3 Arhgap5 Pak2 Wasf1 Map3k1 Arpc3 Noxo1 Arpc2 Pak1 Cyba Abi2 Cybb Pip5k1a Arpc5 Arpc4 Map3k11 Nox1 Ctnnb1 Mapk14 Cdh1 Iqgap1 Cfl1 Map2k3 Ctnna1 Limk1 Pip5k1c Pip5k1b Crk Mapk9 Map2k7 Map2k6 Nckap1 Wasf2 Cyfip2 Abi1 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones Gngt2 Gnat2 Rdh12 Slc24a2 Rgs9bp Pde6c Arr3 Cnga3 Cngb3 Grk1 Gucy2e Rpe65 Pde6h Rdh5 Gnb3 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity Arhgef6 Spata13 Fgd1 Nme1 Arhgef9 Git1 Ngef Dnmbp Mcf2 Arhgap17 Dock10 Dock11 Vav2 Ralbp1 Farp2 Racgap1 Dock6 Bcar3 Arhgef25 Apc Arhgap1 Itsn2 Arhgdia Vav3 Itsn1 Plcg1 Arhgef7 Mcf2l HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network Efna1 Ep300 Kdr Sp1 Adora2a Flt1 Epo Eif3e Ets1 Bhlhe40 Vegfa Crebbp Hif1an Egln2 Egln3 Epas1 Cited2 Pgk1 Slc2a1 Vhl Pou5f1 Sirt1 Slc11a2 Mmp14 Apex1 Abcg2 Eloc Fxn Arnt Elk1 Twist1 Serpine1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity Jun Mdm2 Pou2f1 Mapk8 Nr2c1 Hdac7 Map2k4 Sirt1 Gata2 Hdac1 Foxo1 Rel Mapk14 Hsp90aa1 Nr3c1 Src Smarca2 Ep300 Pkn1 Ar Ncoa2 Ncoa1 Cebpa Kat2b Crebbp Rack1 Hoxb13 Nr2c2 Kat7 Nr0b1 Egr1 Spdef Rxrb Rxra Gsk3b Smarce1 Kat5 Ehmt2 Rxrg Senp1 Carm1 Dnaja1 Zmiz2 Map2k6 Trim24 Appbp2 Pde9a Smarcc1 Tmprss2 Rchy1 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway Jun Crkl Pik3r1 Fos Elk1 Plcg1 Cav1 Srf Grb2 Itgav Sos1 Crk Pik3ca Cav3 Jak1 Shb Shf Pdgfra Rapgef1 Shc1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events Ncan Ptn Mc4r Pomc Psen1 Agrp Egfr Fgf23 Fgfr3 Fgfr4 Fgf15 Cask Cttn Fyn Ncstn Aph1b Src Sdc3 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta Jun Mapk11 Cebpb Gdi1 Eif4ebp1 Pla2g4a Mitf Rab5a Elk4 Hspb1 Usf1 Mapkapk3 Mapkapk2 Krt8 Trp53 Eif4e Mapkapk5 Mef2a Esr1 Rps6ka4 Rps6ka5 Ptgs2 Hbp1 Atf2 Mknk1 Atf6 Mef2c Creb1 Slc9a1 Mapk14 Ddit3 Nos2 Ppargc1a ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events Pxn Tln1 Git1 Prkaca Itga4 Ptk2 Arf6 Itgb1 Crk Bcar1 Spp1 Rac1 Prkar1a Dock1 Prkar1b Mdk Jaml Fn1 Jam2 Ptk2b Cd81 Ptpra Prkacb Adam28 Myh2 Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Ywhaz Src Abi1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network Fzd8 Dkk1 Ror2 Wnt1 Atp6ap2 Lrp6 Lrp5 Igfbp4 Wnt5a Wif1 Wnt7b Wnt3a Wnt7a Wnt2 Fzd10 Wnt3 Fzd1 Cthrc1 Fzd2 Kremen2 Fzd5 Fzd4 Ryk Fzd7 Fzd6 Kremen1 Fzd9 Rspo1 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network Fosl1 Jun Cdkn1b Fos Il2 Il4 Ifng Nfatc1 Csf2 Junb Nfatc3 Ets1 Nfatc2 Atf2 Myb Il10 Mmp9 Th Plau Gata2 Myc Tgfb1 Creb1 Ccn1 Col1a2 Ctnnb1 Acta1 Cdkn2a Cdk1 Pten Atf3 Maf Nr3c1 Ep300 Dmp1 Gja1 Edn1 Elf1 Penk Il5 Trip6 Sp1 Dmtf1 Mt2 Nts Mafg Crtc1 Bag1 Fosb Bcl2l11 Tcf7l2 Cbfb Cops5 Trp53 Fabp4 Timp1 Esr1 Agt Nppa Fosl2 H2-Q10 Egr1 Ccnd1 Hif1a Il6 Ccl12 Mmp1a Jund Dusp1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events Stat5a Lyn Ptpn11 Pik3r1 Il5 Grb2 Stat5b Pim1 Jak2 Pik3ca Csf2rb2 Il5ra Cish Sdcbp INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling Arhgef6 Jun Pxn Ilk Rac1 Myl12a Ilkap Ruvbl1 Rhog Ppp1r14a Ppp1r12a Ppp1r14c Ppp1r14b Elmo2 Nck2 Tns1 Git2 Parvg Akt1 Tacc3 Snai1 Lims2 Rictor Zeb1 Ccnd1 Actn1 Parvb Creb1 Gsk3b Zyx Cdc37 Parva Ctnnb1 Ckap5 Parp1 Ruvbl2 Diaph1 Iqgap1 Aurka Hsp90aa1 Arhgef7 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events Gja1 Pip5k1c Ptpn11 Pik3r1 Ctnnd1 Cdh2 Mapk8 Rhoa Ptpn1 Rac1 Fer Gsn Lrp5 Plcg1 Rock1 Ctnnb1 Daglb Camk2g Mapre1 Dctn1 Gap43 Kif5b Cnr1 Pik3ca Fgfr1 Jup Gria2 Cttn Dagla Axin1 Myl2 Ctnna1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor Rarg Thrb Thra Bcl2 Nr1h4 Nr1h3 Nr1h2 Ncoa1 Ppard Ppara Abca1 Nr4a1 Srebf1 Vdr Pparg Tgfb1 Ncor2 Rxrb Tnf Rxra Rxrg Fam120b Rara Rarb Med1 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network Trp63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network Jun Stat5a Ctsd Hdac4 Col18a1 Mpg Nrip1 Sra1 Ube2m Apbb1 Ebag9 Safb Phb2 Pdia2 Anp32a Ddx17 Ap1b1 Ddx54 Pou4f1 Lcor Pou4f2 Nr0b2 Cd82 Trim59 Dscam Pgr Axin2 Ncoa7 Chuk Myc Atp5pf Hdac1 C3 Mta1 Greb1 Hsf2 Ncoa3 Xbp1 Esr2 Ndufv3 Abca3 Prdm15 Calcoco1 Uba3 Nedd8 Ncor1 Ep300 Cebpb Ncoa2 Ncoa1 Lmo4 Prl Pcna Esr1 Brca1 Smad4 Ncor2 Nr0b1 Ccnd1 Med1 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling Stat5a Itga5 Pik3r1 Mapk8 Mapk1 Mapk3 Itgb1 Ets1 Rac1 Fyn Mmp2 Pld2 Dok2 Pak1 Akt1 Foxo1 Mapk14 Grb14 Fgf2 Angpt2 Stat5b Angpt4 Agtr1a F2 Fes Elf2 Tnip2 Plg Bmx Grb7 Shc1 Rasa1 Pxn Elf1 Ptpn11 Angpt1 Nck1 Ptk2 Grb2 Crk Nos3 Fn1 Cdkn1a Tek Elk1 Tnf Nfkb1 Pik3ca Rela DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells Fosl1 Jun Il2ra Nras Prkcb Fos Prkce Il2 Ifng Fasl Mapk8 Mapk1 Nfatc1 Mapk3 Junb Nfatc3 Nfatc2 Il2rg Tnfrsf4 Il2rb Prkcq Tnfrsf9 Ifna16 B2m Gzmb Ifnar1 Eomes Ifnar2 Egr4 Cd8a Cd8b1 Tnfrsf18 Raf1 Prkca Hras H2-Q10 Map2k2 Map2k1 Stat4 Ptpn7 Braf Elk1 Egr1 Cd3e Tnf Mapk9 Cd3g Cd247 Prf1 Cd3d Kras SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase Jun Itga5 Pik3r1 Rras Mapk8 Mapk1 Itgav Rhoa Itgb1 Ets1 Bcar1 Map2k4 Rac1 Dock1 Elmo1 Fyn Yes1 Wasl Pak1 Rock2 Acta1 Itgb5 Bmx Grb7 Arhgef7 Src Rasa1 Pxn Tln1 Vcl Arhgef11 Nck1 Asap1 Rap1a Arhgef28 Mapk8ip3 Sh3gl1 Arhgap26 Ptk2 Capn2 Raf1 Klf8 Ptpn21 Grb2 Sos1 Crk Arhgap35 Map2k1 Nck2 Git2 Braf Rap1b Actn1 Ccnd1 Plcg1 Mapk9 Pik3ca Rapgef1 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions Lamb2 Lama2 Lamb3 Lama5 Lamb1 Lama1 Lamc2 Lama3 Itgb4 Itga6 Lamc1 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway Fancl Fanca Mre11a Nbn Fancc Fance Fancf Fancg Rad50 Fancd2 Topbp1 Brca1 H2ax Ube2t Blm Atm Chek1 Rad9a Top3a Wdr48 Fanci Fancm Usp1 Fancb Palb2 Rfc5 Rfc3 Rfc4 Faap100 Rfc2 Rpa1 Rpa2 Hus1 Rad17 Atrip Brip1 Cenps Fbxw11 Brca2 Xrcc3 Rad1 Faap24 Fan1 Hes1 Btrc VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms Rrad Krt14 Wwp1 Rab38 Krt5 Nrg1 Cebpd Mre11a Adrm1 Il1a Axl Fbxw7 Perp Trp63 Top2a Mdm2 Vdr Hbp1 Fosl2 Atm Ada Rack1 Sfn Col5a1 Gsk3b Brca2 Yap1 Itga3 Hes1 Dlx5 Bdkrb2 Ppp2r5a Hells Cdkn2a Igfbp3 Itch Sec14l2 Stxbp4 T Fasn Tcf7l1 Notch1 Pou2f2 Ccnb2 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis Srebf1 Madd App Arhgdib Tnfrsf1a Slk Tradd Cfl2 Xiap Cradd Sptan1 Traf2 Lmna Apaf1 Gas2 Top1 Tfap2a Vim Numa1 Lmnb1 Bax Lmnb2 Pidd1 Gsn Casp7 Krt18 Casp4 Satb1 Map3k1 Casp2 Casp1 Diablo Dffa Dffb Birc3 Acta1 Limk1 Gzmb Bcl2 Ptk2 Casp6 Tnf Casp9 Birc2 Parp1 Prf1 Bid Casp8 Casp3 Ripk1 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity Arhgef6 Spata13 Rasgrf1 Rasgrf2 Ngef Mcf2 Arhgap17 Vav2 Ralbp1 Racgap1 Dock6 Arhgef25 Arhgap1 Sos1 Arhgdia Rac1 Dock1 Vav3 Elmo1 Trio Tiam2 Arhgef2 Dock2 Abr Eps8 Def6 Rap1gds1 Prex1 Vav1 Bcr Kalrn Arhgap9 Tiam1 Arhgef7 Abi1 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling Tln1 Itgam Rap1a Rhoa Mst1 Itgb2 Mmp2 Jam2 Mmp9 Plau Myh2 Thy1 Rap1b Hck Tnf Selp Rock1 Il6 Lrp1 Selplg Ccn2 Jam3 Plat Nfkb1 Ager Icam1 Plaur Mst1r Apob Plg ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway Nme1 Pip5k1a Arf6 Kalrn Mapk1 Mapk3 Tiam1 Rhoa Plaur Rac1 Arf1 Pld1 Rab11fip3 Rab11a Pld2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells Jun Prkcb Pik3r1 Fos Pla2g4a Mapk8 Mapk1 Mapk3 Nfatc2 Map2k4 Syk Fyn Pld2 Pak2 Map3k1 Lyn Chuk Inpp5d Akt1 Cbl Vav1 Itk Plpp1 Fcer1a Shc1 Klrg1 Gab2 Hcls1 Rasa1 Cblb Wipf1 Pxn Fcer1g Lat2 Lcp2 Ptpn11 Ptpn13 Pla2g1b Ms4a2 Fcgr2b Ptk2 Dok1 Raf1 Grb2 Sos1 Hras Fer Lat Map2k2 Map2k1 Sphk1 S1pr1 Plcg1 Ikbkb Ikbkg Map2k7 Nfkb1 Pik3ca Dusp1 Btk Rela S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway Cxcr4 Gnai1 Gnai3 Mapk1 Flt1 Mapk3 Rhoa Pdgfrb Vegfa Pdgfb Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Gna13 Akt1 S1pr3 Akt3 Jak2 Src A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling Pxn Vcam1 Itgb7 Itgb1 Rhoa Itga4 Madcam1 Ptk2 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling Rasgrf1 Crkl Stat3 Nras Pik3r1 Mapk1 Mapk3 Rhoa Rac1 Dock1 Elmo1 Shc1 Mcf2l Gab2 Rasa1 Bdnf Ptpn11 Rap1a Gab1 Ngf Frs2 Frs3 Matk Sqstm1 Faim Prkci Maged1 Ngfr Grb2 Dnaja3 Ntf4 Sos1 Shc3 Ntf3 Crk Shc2 Gipc1 Hras Rgs19 Nedd4l Abl1 Arhgap32 Rit1 Rit2 Ehd4 Ntrk2 Rhog Ntrk1 Map2k1 Ntrk3 Rap1b Dnm1 Ccnd1 Plcg1 Tiam1 Pik3ca Kras Rapgef1 Prkcz CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events Lck Nras Pik3r1 Rap1a Arf6 Rhoa Hras Rac1 Blk Fyn Syk Lat Yes1 Cyth2 Sgk1 Zap70 Cyth3 Cyth1 Dapp1 Pdpk1 Inppl1 Lyn Plekha2 Plekha1 Plcg2 Inpp5d Blnk Arap3 Fgr Adap1 Pik3cg Hck Arf5 Pik3r6 Foxo3 Plcg1 Pik3cb Pik3ca Arf1 Pten Itk Hsp90aa1 Kras Btk Src ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events Stat5a Wwp1 Nrg1 Pik3r1 Prl Mdm2 Prlr Mapk1 Grb2 Mapk3 Fyn Tab2 Wwox Erbb2 Erbb4 Lrig1 Adam17 Ereg Hbegf Nrg2 Yap1 Btc Cbfa2t3 Stat5b Nrg4 Nrg3 Jak2 Dlg4 Pik3cb Grin2b Itch Pik3ca Ncor1 Shc1 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events Stat5a Stat3 Nras Stat1 Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk1 Grb2 Csf2 Mapk3 Sos1 Hras Csf2rb2 Cish Syk Map2k2 Prkacb Map2k1 Lyn Inpp5d Ikbkb Ywhaz Ccl12 Pim1 Stat5b Jak2 Csf2ra Pik3ca Osm Irf8 Kras Shc1 Gab2 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta Pkn1 Mapk12 Map2k6 Mapk13 Map2k3 Ccnd1 Eef2k Map3k20 Snta1 Stmn1 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction Vasp Efna1 Aqp5 Kifc3 Mgat3 Aqp3 Git1 Pip5k1c Nectin2 Lpp Afdn Myo6 Epha2 Vcl Stx4 Nck1 Plekha7 Ctnnd1 Camsap3 Egfr Arf6 Rhoa Egf Igf1 Igf1r Hgf Actn1 Rock1 Zyx Ctnnb1 Cdh1 Diaph1 Nckap1 Met Exoc3 Exoc4 Myl2 Ctnna1 Cyfip2 Lima1 Abi1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 Mapk11 Prkaca Prkcb Pik3r1 Myof Cdh5 Ptprj Camkk2 Akap1 Mapkapk2 Mapk1 Sh2d2a Hsp90ab1 Itgav Hgs Mapk3 Ptpn2 Rhoa Vtn Fyn Pak2 Ptk2b Itgb3 Akt1 Ptpn6 Cbl Fbxw11 Cav1 Ctnnb1 Mapk14 Iqgap1 Fes Arf1 Map2k3 Hsp90aa1 Ctnna1 Src Pxn Grb10 Dnm2 Ptpn11 Kdr Vcl Nck1 Gab1 Ptk2 Raf1 Grb2 Prkca Flt1 Vegfa Nos3 Map2k2 Map2k1 Pdpk1 Nck2 Braf Plcg1 Rock1 Prkcd Map2k6 Pik3ca Shb VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation Fosl1 Birc5 Npm1 Eif4e Riox2 Peg10 Bmi1 Ndufaf2 Bax Bcat1 Ddx18 Trrap Shmt1 Taf12 Rcc1 Mmp9 Hspd1 Prdx3 Supt3 Cad Nme2 Myc Taf4b Mtdh Actl6a Mta1 Ldha Cdc25a Serpini1 Odc1 Taf9 Eif4g1 Gpam Rpl11 Id2 EG433182 Eif2s1 Supt7l Pfkm Pim1 Lin28b Myct1 Ccnd2 Tfrc Polr3d Hmga1 Pdcd10 Hspa4 Ireb2 Eif4a1 Hsp90aa1 Ubtf E2f3 Tk1 Tert Max Huwe1 Ep300 Nme1 Nbn Kat2a Trp53 Crebbp Smad3 Smad4 Slc2a1 Ruvbl1 Cdk4 Snai1 Kat5 Ruvbl2 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta Dusp16 Lck Traf6 Mapk11 Pak3 Prkg1 Map3k3 Ccm2 Map3k12 Ralb Map2k4 Rac1 Blk Fyn Yes1 Tab1 Pak2 Pak1 Lyn Fgr Hck Mapk14 Map2k6 Rala Dusp1 Map2k3 Ripk1 Dusp10 Dusp8 Src SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) Stat5a Crkl Stat3 Stat1 Pik3r1 Mitf Mapk8 Socs1 Mapk3 Lyn Akt1 Ptpn6 Cbl Foxo3 Vav1 Pten Shc1 Kit Bcl2 Grb10 Ptpn11 Stap1 Ptpro Gab1 Spred1 Spred2 Matk Epor Dok1 Grap2 Raf1 Pik3c2b Snai2 Sh2b2 Kitlg Sh2b3 Grb2 Map4k1 Sos1 Tec Epo Hras Crebbp Fer Map2k2 Map2k1 Pdpk1 Bad Gsk3b Jak2 Pik3ca GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network Mapk9 Bmp4 Fgf7 Gpc3 Shh Furin Ptch1 Mapk8 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events Pxn Itga9 Csf2 Itgb1 Bcar1 Vegfa Spp1 Rac1 Tnc Adam12 Adam15 Sat1 Vegfd Fn1 Vegfc Tgm2 Paox Adam2 F13a1 Adam8 Vcam1 Kcnj15 Csf2ra Nos2 Src DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining Prkdc Pnkp Polm Nhej1 Dntt Aptx Dclre1c Lig4 Aplf Xrcc4 Poll Xrcc6 Xrcc5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) Jun Crkl Pik3r1 Eif4ebp1 Rab5a Ptprj Mapk8 Mapk1 Eif4e Hgs Mapk3 Ptpn2 Rhoa Ets1 Bcar1 Map2k4 Rac1 Pak2 Map3k1 Wasl Pak1 Inpp5d Akt1 Cbl Mtor Ctnnb1 Cdh1 Pard6a Ctnna1 Shc1 Gab2 Src Sh3gl2 Pxn Ptpn11 F2rl2 Nck1 Rap1a Gab1 Arf6 Ptk2 Raf1 Prkci Apc Grb2 Sos1 Crk Ptpn1 Hras Map2k2 Map2k1 Pdpk1 Inppl1 Nck2 Rap1b Snai1 Hgf Egr1 Bad Plcg1 Akt2 Rptor Kpnb1 Numb Sh3kbp1 Eps15 Mlst8 Ranbp9 Rin2 Met Arhgef4 Deptor Pak4 Akt1s1 Pik3ca Muc20 Ranbp10 Rapgef1 Prkcz EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway Rasa1 Tln1 Stat3 Pip5k1c Nras Stat1 Ptpn11 Pik3r1 Nck1 Gab1 Ptk2 Egfr Gnai1 Gnai3 Mapk1 Grb2 Mapk3 Sos1 Ptpn1 Hras Gsn Egf Wasl Pak1 Nck2 Ptpn6 Plcg1 Pik3cb Pik3ca Kras Shc1 Src PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events Vasp Grk3 Snx2 Pkn1 Gng2 Snx1 Arrb1 Dnm2 Akap13 Prkcg Prkcb Pik3r1 F2rl2 Gnb1 Gnai1 Gnai3 Prkca Rhoa Arhgdia Gna12 Gnaz Nos3 Gnao1 Plcb2 Gnai2 Gna11 Gna15 Gna14 Rock2 Gnaq Gna13 Dnm1 Rock1 Zyx Prkcd F2 Pik3ca Plcb3 F2r Myl2 Arhgef1 Plcb1 Trpc6 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events Dnm2 Itga5 Cxcl12 Sdc4 Fgf6 Cxcr4 Nudt16l1 Tfpi Ptk2 Prkca Rhoa Itgb1 Gipc1 Rac1 Tnc Adam12 Ccl5 Mdk Fn1 Mmp9 Tnfrsf13b Sdcbp Lama1 Lama3 Thbs1 Actn1 Prkcd Fgf2 F2 Fgfr1 Plg Fzd7 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway Mdm2 Smyd2 Cse1l Mapk8 Kat8 Fbxo11 Ppp1r13l Prmt5 Kmt5a Dyrk2 Ptpa Rpl23 Ube2d1 Ccng1 Chek2 Setd7 Cop1 Ttc5 Pin1 Mdm4 E4f1 Ppm1d Daxx Akt1 Ppp2ca Rpl11 Mapk14 Nedd8 Cdkn2a Huwe1 Ep300 Trim28 Csnk1a1 Csnk1g3 Kat2b Csnk1g1 Csnk1g2 Trp53 Skp2 Crebbp Atm Usp7 Chek1 Abl1 Csnk1d Hipk2 Csnk1e Cdk2 Ccna2 Gsk3b Kat5 Prkcd Mapk9 Rchy1 Yy1 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes Fosl1 Jun Cblb E2f1 Egr4 Il2ra Il5 Fos Batf3 Il2 Il4 Pou2f1 Ifng Fasl Cd40lg Nfatc1 Csf2 Junb Ptpn1 Nfatc3 Ptgs2 Nfatc2 Pparg Cdk4 Rnf128 Ctla4 Irf4 Ptprk Dgka Slc3a2 Egr3 Ikzf1 Foxp3 Egr1 Tnf Egr2 Gata3 Itch Tbx21 Casp3 Prkcq Maf E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events Ctnnb1 Cdh1 Jup S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway Jun Gna15 Irs1 Gna14 Pak1 Gnaq Gna13 Fos S1pr2 Elk1 Cdh5 Gnai1 Mapk8 Gnai3 Mapk14 Mapk1 Mapk3 Rhoa Rac1 Gna12 Gnaz Gnao1 Gnai2 Gna11 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling Gng2 Ar Pik3r1 Fos Gnb1 Ptk2 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Rac1 Gnaz Gnao1 Plcb2 Gnai2 Map2k2 Map2k1 Plcg2 Akt1 Gnrh1 Shbg Pelp1 Plcg1 Creb1 Pik3ca Plcb3 Plcb1 Src PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events Ccne1 Plk3 Trp53 Chek2 Cdc25c VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 Fosl1 Ep300 Jun Gja1 Sp1 Dmtf1 Nfatc1 Junb Nfatc3 Nfatc2 Itgb4 Fosl2 Nos3 Mmp2 Mmp9 Plau Lama3 Ccna2 Ccnd1 Hmox1 Txlng Il6 Usf2 Col1a2 Lif Ccl12 Dcn Thbd Mmp1a Mgp Atf4 Jund Cdkn2a Plaur ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway Trim28 Mre11a Nbn Mdm2 Rad50 Fancd2 Brca1 H2ax Blm Atm Chek2 Abl1 Rad9a Top3a Cop1 Ctbp1 Ywhab Cdc25a Dclre1c Rad17 Xrcc4 Kat5 Mdc1 Terf2 Smc3 Ube2n Abraxas1 Bid Rbbp8 Uimc1 Trp53bp1 Smc1a Cdc25c HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha Nfkbia Bcl2 Tnfrsf1a Bag4 Fasl Mapk8 Tradd Cradd Traf2 Casp6 Apaf1 Casp7 Casp2 Daxx Chuk Map3k14 Map3k5 Tnf Birc3 Casp9 Map2k7 Cd247 Nfkb1 Cflar Bid Casp8 Casp3 Traf1 Ripk1 Rela Fas Fadd ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling Sftpa1 Myd88 Ly96 Tlr1 Chuk Vcan Saa2 Cd14 Irak4 Ticam1 Tlr6 Tirap Tlr4 S100a9 S100a8 Tlr3 Tlr2 Ikbkb Ikbkg Rhoa Irak2 Irak1 Bgn Hspd1 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events Stat5a Il1b Stat3 Stat1 Il2 Ifng Ebi3 Il6st Il12a Il12rb2 Il27 Il27ra Stat2 Jak1 Stat4 Tgfb1 Il12b Il18 Tnf Il6 Jak2 Il12rb1 Gata3 Tyk2 Tbx21 Il17a P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling Mapk10 Psen1 Pik3r1 App Mapk8 Xiap Apaf1 Rhoa Arhgdia Rac1 Prkacb Diablo Chuk Akt1 Birc3 Plg Shc1 Irak1 Myd88 Traf6 E2f1 Bdnf Ngf Sqstm1 Prkci Bcl2l11 Maged1 Ngfr Trp53 Ntf4 Ntf3 Casp6 Rhoc Rhob Lingo1 Furin Mmp3 Omg Mag Mageh1 Smpd2 Bex3 Bex1 Nsmce3 Ntrk1 Rtn4 Ywhae Mmp7 Ripk2 Ndn Prdm4 Sort1 Zfp369 Bad Adam17 Casp9 Ikbkb Mapk9 Birc2 Ikbkg Pik3ca Casp3 Ncstn Aph1b Prkcz CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway Pip5k1b Nkd2 Ranbp3 Dvl1 Lrp6 Klhl12 Dvl2 Dvl3 Pi4k2a Cav1 Gsk3b Csnk1g1 Apc Wnt3a Ctnnb1 Gsk3a Ppp2r5a Cul3 Fzd5 Axin1 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway Jun Stat1 Ptpn11 Pik3r1 Fos Ctnnd1 Gab1 Frs2 Cdh2 Runx2 Mapk1 Sdc2 Grb2 Mapk3 Sos1 Fgf15 Spp1 Spry2 Ptk2b Mmp9 Plau Pdpk1 Camk2a Akt1 Cbl Plcg1 Klb Il17rd Fgf1 Fgf23 Ncam1 Fgfr3 Fgfr4 Ssh1 Fgfr2 Cdh1 Rps6ka1 Stat5b Plaur Pak4 Pik3ca Fgfr1 Cttn Shc1 Src ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events Smad1 Acvr1 Tlx2 Smad9 Fkbp1a Amhr2 Amh Bmp7 Smad5 Smad4 Bmpr2 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity Mak Cmtm2b Pa2g4 Ube3a Svil Tmf1 Ctdsp1 Nkx3-1 Zmiz1 Pawr Snurf Ube2i Appl1 Hnrnpa1 Pias1 Ncoa6 Ccnd3 Nrip1 Kdm3a Tgfb1i1 Tcf4 Vav3 Gsn Pias3 Ptk2b Tgif1 Pias4 Akt1 Pelp1 Srf Ctnnb1 Uba3 Cdkn2a Prkdc Ar Ncoa2 Xrcc6 Brca1 Xrcc5 Cdk6 Ccnd1 Carm1 Ranbp9 Hip1 Lats2 Tmprss2 Fhl2 Casp8 Kdm4c Kdm1a Znf318 Prdx1 Fkbp4 Patz1 Med1 Rps6ka3 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes Vasp Pip5k1a Pik3r1 Akt1 Ctnnd1 Plcg1 Egfr Akt2 Zyx Ctnnb1 Casr Ajuba Cdh1 Rhoa Rac1 Pik3ca Jup Fyn Ctnna1 Src IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events Jun Mapk11 Cebpb Stat3 Stat1 Cebpd Ptpn11 Pik3r1 Fos Mitf Lmo4 Gab1 Pias1 Il6st Grb2 Crp Timp1 Junb Sos1 Hsp90b1 Lbp Mcl1 Map2k4 Rac1 Ptpre Fgg Tnfsf11 Jak1 A2m Pias3 Bcl2l1 Il6ra Myc Socs3 Akt1 Hck Foxo1 Vav1 Il6 Prkcd Mapk14 Map2k6 Jak2 Pik3ca Tyk2 Irf1 Gab2 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway Epha2 Epha3 Epha4 Epha5 Epha6 Epha7 Efna5 Epha8 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway Nbn Mdm2 Rad51 Fancd2 Topbp1 Chek1 Rad9a Mcm7 Smarcal1 Ppp2r2b Timeless Cdk2 Cep164 Cdc6 Rfc5 Tipin Rfc3 Mcm2 Rfc4 Ywhab Rfc2 Rpa1 Rpa2 Hus1 Cdc25a Ppp2ca Rad17 Plk1 Atrip Ccna2 Clspn Fbxw11 Brca2 Rad1 Ywhaz Ppp2r1a Btrc Cdc25c DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin Axin2 Cul1 Skp1 Dvl1 Lrp6 Dvl2 Dvl3 Csnk1a1 Gsk3b Apc Wnt3a Ctnnb1 Gsk3a Fzd5 Btrc Axin1 Csnk1d Csnk1e IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway Irs1 Pxn Irs2 Grb10 Crkl Ptpn11 Pik3r1 Ptk2 Raf1 Grb2 Sos1 Ptpn1 Crk Bcar1 Hras Igf1 Ywhae Pdpk1 Rack1 Nck2 Igf1r Prkd1 Akt1 Bad Prkcd Ywhaz Pik3ca Shc1 Prkcz CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin Casp1 Map2k1 Pgr Vcam1 Il1b Nlrp1a Antxr2 Il18 Antxr1 Tnf Mapk1 Map2k7 Map2k6 Mapk3 Map2k4 Map2k3 Map2k2 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods Gnb1 Gngt1 Slc24a1 Rdh12 Pde6a Pde6b Rgs9bp Gnat1 Cnga1 Pde6g Rho Sag Grk1 Gucy2e Rpe65 Rdh5 Guca1b Guca1a Gnb5 Rgs9 Lrat Gucy2f FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network Ccne1 Ep300 Birc5 Fos Sp1 Gas1 Aurkb Skp2 Nfatc3 Esr1 Crebbp Chek2 Mmp2 Cdk4 Cdk2 Map2k1 Myc Plk1 Ccna2 Ccnd1 Brca2 Cenpb Gsk3a Hspa1a Onecut1 Nek2 Rb1 Cdkn2a Foxm1 Cdk1 Cks1b Tgfa Lama4 Xrcc1 Etv5 Cenpf Cenpa Cdc25b Ccnb2 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events Gng2 Arrb1 Prkcg Prkcb Gnb1 Grk2 Prkce Rab5a Prkca Pld1 Plcb2 Gnai2 Gna15 Gna14 Pdpk1 Lyn Akt1 Fgr Pik3cg Hck Cbl Arrb2 Dnm1 Pik3r6 Plcb3 Cxcr1 Plcb1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions Fgb Fga F10 Tgfbi Itgax F11r Icam4 Icam2 Itgam Itgal Fcgr3 Cd40lg Itgad Itgb2 Fgg Kng2 Plau Vcam1 C3 Thy1 Ccn1 Jam3 Plat Icam1 Plaur Spon2 Proc Gp1ba INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport Gm14226 Gys1 Stx4 Ppp1cc Ins2 Lnpep Rhoq Trip10 Ppp1r3a Vamp2 Prkci Insr Ywhah Ywhag Ywhae Ywhab Akt1 Sfn Akt2 Gsk3b Tbc1d4 Ywhaz Slc2a4 Stxbp4 Prkcz PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway Stat5a Mapk10 Stat3 Stat1 Pik3r1 Eif2ak2 Ptprj Mapk8 Mapk1 Itgav Mapk3 Ksr1 Ptpn2 Brk1 Rhoa Arhgdia Bcar1 Map2k4 Rac1 Baiap2 Arpc1b Blk Actr2 Actr3 Ppp2r2b Arpc3 Arpc2 Itgb3 Pak1 Lyn Arpc5 Arpc4 Fgr Ppp2ca Hck Srf Ppp2r1a Pten Shc1 Src Rasa1 Grb10 Ptpn11 Nck1 Rap1a Gab1 Dok1 Sla Arap1 Rab4a Usp6nl Grb2 Prkca Tagln Myocd Sos1 Dock4 Crk Ptpn1 Actn4 Csk Hras Nherf2 Nherf1 Sipa1 Ywhah Ywhag Ywhae Ywhab Braf Sfn Elk1 Plcg1 Prkcd Ywhaz Mapk9 Jund Kras Jun Nras Fos Prkce Pla2g4a Vav2 Rab5a Fyn Yes1 Pin1 Wasl Myc Eps8 Pik3cg Pik3r6 Cbl Lrp1 Stat5b Iqgap1 Lck Dnm2 Afdn Raf1 Pdgfrb Pdgfb Abl1 Pag1 Arhgap35 Map2k2 Map2k1 Nck2 Sphk1 S1pr1 Rap1b Map2k7 Nckap1 Jak2 Pik3cb Pik3ca Wasf2 Cttn Rapgef1 Cyfip2 Rps6ka3 Abi1 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway Acvr1 Fkbp1a Acvrl1 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway Tln1 F11r Pip5k1c Nectin2 Afdn Pik3r1 Rap1a Vav2 Farp2 Ptk2 Itgav Pdgfrb Crk Pdgfb Rac1 Nectin1 Nectin3 Ptprm Cldn1 Itgb3 Rap1b Ctnnb1 Cdh1 Iqgap1 Pik3ca Ctnna1 Rapgef1 Src BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway Nfkbia Jun Pik3r1 Fos Vav2 Mapk8 Mapk1 Nfatc1 Mapk3 Ets1 Rac1 Syk Map3k1 Lyn Chuk Inpp5d Akt1 Ptpn6 Map3k7 Mapk14 Pten Shc1 Rasa1 Traf6 Fcgr2b Dok1 Raf1 Ppp3ca Grb2 Map4k1 Sos1 Csk Hras Pag1 Cd72 Cd22 Malt1 Card11 Map2k1 Dapp1 Cd79a Pdpk1 Cd79b Ibtk Bcl10 Plcg2 Ptprc Blnk Nfkbib Ppp3cc Ppp3cb Elk1 Cd19 Bcl2a1d Sh3bp5 Ikbkb Ikbkg Camk2g Nfkb1 Pik3ca Btk Pou2f2 Rela REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity Cdkn1b Arhgef15 Ngef Akap13 Mcf2 Arhgef11 Vav2 Arhgef28 Arhgdib Arhgef25 Arap1 Rhoa Arhgdia Vav3 Arhgap35 Arhgap5 Trio Ect2 Arhgef2 Abr Arap3 Def6 Srgap1 Vav1 Arhgef3 Bcr Ophn1 Arhgap9 Arhgef17 Arhgdig Arhgef10 Arhgef12 Myo9b Arhgef18 Plekhg6 Farp1 Arhgap6 Net1 Arhgap4 Arhgef10l Dlc1 Arhgap8 Arhgef1 Mcf2l EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin Snap25 Syt1 Stx1a Stxbp1 Vamp2 Unc13b Chrna1 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway Mark2 Adam10 Neurl1a Notch4 Notch2 Notch3 Fbxw7 Dtx1 Dll1 Il4 Dll3 Dll4 Mycbp Mfap5 Jag2 Jag1 Mfap2 Dlk1 Mib1 Cntn1 Cntn6 Dner Lnx1 Ctbp1 Cul1 Myc Skp1 Hdac1 Cbl EG433182 Gata3 Btrc Rab11a Ncor1 Ptcra Ep300 Skp2 Furin Adam12 Cdkn1a Spen Ncor2 Dnm1 Ccnd1 Maml1 Maml2 Numb Eps15 Itch Rbbp8 Kdm1a Rbpj Yy1 Notch1 Ncstn Aph1b GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network Gpc2 Mdk IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 Stat5a Lck Bcl2 Il2ra Ptpn11 Elf1 Pik3r1 Sp1 Il2 Il4 Ccnd3 Fasl Grb2 Sos1 Jak3 Cdk6 Jak1 Bcl2l1 Lta Myc Foxp3 Ccna2 Il2rg Stat5b Prf1 Ccnd2 Pik3ca Il2rb Shc1 Gab2 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events Jun Mapk10 Stat3 Nrg1 Nras Ptpn11 Prkaca Pik3r1 Fos Raf1 Mapk8 Mapk1 Grb2 Mapk3 Sos1 Hras Rac1 Erbb3 Nfatc4 Nf2 Chrne Usp8 Rnf41 Map2k2 Dock7 Map2k1 Akt1 Ppp3cb Bad Erbb2 Mtor Mapk9 Nrg2 Jak2 Pik3cb Pik3ca Kras Shc1 Src Chrna1 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events Vasp Gng2 Arrb1 Prkcg Prkcb Gnb1 Rab5a Prkca Elmo1 Plcb2 Gnai2 Pld2 Rab7 Gna15 Cxcr2 Gna14 Pdpk1 Rac2 Lyn Dock2 Akt1 Fgr Pik3cg Ppp2ca Hck Cbl Arrb2 Dnm1 Pik3r6 Ppp2r1a Plcb3 Rab11a Plcb1 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks Foxa1 Foxa2 Foxa3 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events Sdc2 Sdc1 Sdc4 Sdc3 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions Fgb Fga Tgfbi F11r Kdr Sdc4 Itgav Lamb1 Vtn Pdgfrb Itga2b Vegfa Spp1 Pdgfb Tnc Fgg Fn1 Lamc1 Plau Itgb3 Col1a1 Col4a3 Sphk1 L1cam Col4a4 Thbs1 Pecam1 Thy1 Cd47 Edil3 Col4a1 Ibsp Fbn1 Col4a5 Col4a6 Ccn1 Col1a2 Sdc1 Plaur Lama4 Tgfbr2 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events Jun Stat5a Mapk11 Stat3 Il2ra Nras Stat1 Prkcb Pik3r1 Fos Prkce Il2 Ifng Mapk8 Mapkapk2 Mapk1 Socs1 Mapk3 Rhoa Jak3 Jak1 Syk Fyn Ptk2b Dok2 Myc Socs2 Stam2 Ikzf3 Stam Mapk14 Il2rg Stat5b Il2rb Shc1 Gab2 Rasa1 Irs1 Lck Bcl2 Irs2 Ptpn11 Raf1 Grb2 Sos1 Hras Cish Map2k2 Cdk2 Map2k1 Socs3 Mapk9 Pik3ca Kras GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway Gpc1 Gpc3 Gpc2 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway Npas2 Nr1d1 Nono Cry1 Cry2 Bhlhe40 Clock Bmal1 Chek1 Per2 Per1 Wdr5 Timeless Csnk1e IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events Stat5a Il18r1 Il1b Stat3 Il2ra Stat1 Fos Il2 Il4 Ifng Fasl Socs1 Stat6 Atf2 Sphk2 Rab7 Mtor Mapk14 Il2rg Il2rb Nfkb2 Map2k3 Ccr5 Relb Gadd45g B2m Gzma Gadd45b Gzmb Lck Hlx Eomes Ccl4 Il1r1 Cd8a Cd8b1 Il12a Il12rb2 H2-Q10 Ripk2 Stat4 Il12b Il18 Il18rap Cd3e Cd4 H2-Eb1 Cd3g Map2k6 Nfkb1 Cd247 Jak2 Cd3d Il12rb1 Tyk2 Tbx21 Nos2 Rela BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions Plau Vcam1 Edil3 Itga4 Madcam1 Fbn1 Ccn1 Itgb8 Itgb6 Itgav Itgb7 Itgb5 Vtn Sdc1 Plaur Tgfbr1 Fn1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis Cdkn1b Pik3r1 Mapk1 Ilk Itgav Mapk3 Rhoa Vtn Bcar1 Spp1 Rac1 Vav3 Ptk2b Itgb3 Akt1 Edil3 Cbl Col1a2 Fgf2 Tgfbr2 Hsp90aa1 Src Irs1 Pxn Tln1 Angptl3 F11r Mfge8 Adgra2 Ptpn11 Kdr Vcl Pi4kb Pi4ka Pik3c2a Csf1r Ptk2 Csf1 Vegfa Col11a1 Col11a2 Igf1 Fn1 Col2a1 Col3a1 Col1a1 Col6a1 Col5a2 Igf1r Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Col4a5 Rock1 Col6a3 Col4a6 Sdc1 Pik3ca Casp8 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III Ep300 Hdac4 Tuba1b Mef2d Acss1 Acss2 Hoxa10 Kat2b Tubb2a H1-4 Trp53 Xrcc6 Crebbp Bax Sirt3 Sirt2 Sirt1 Sirt7 Cdkn1a Foxo4 Foxo3 Foxo1 Fhl2 Myod1 Ppargc1a RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling Rarg Ep300 Ncoa2 Ncoa1 Prkaca Prkcg Nrip1 Kat2b Mapk8 Mapk1 Mnat1 Vdr Ccnh Prkca Mapk3 Hdac3 Cdk7 Rbp1 Crebbp Hdac1 Ncor2 Akt1 Ncoa3 Rxrb Rxra Rxrg Mapk14 Cdk1 Rara Rarb HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha Rack1 Eloc Arnt Hif1a Cops5 Trp53 Rbx1 Hif3a Cdkn2a Hif1an Os9 Egln2 Naa10 Egln3 Cul2 Hsp90aa1 Vhl FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network Sftpa1 Ep300 Jun Cdkn1b Cebpb Ar Nkx3-1 Shh Fos Sp1 Ins2 Col18a1 Pou2f1 Nrip1 Vtn Esr1 Brca1 Crebbp Ap1b1 Pisd Sftpd Cyp2c55 Nfia Nfic Serpina1d Scgb1a1 Dscam Nr2f2 Gcg Foxa1 Atp5pf Foxa2 Foxa3 Ncoa3 Xbp1 Ndufv3 Prdm15 Apob NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway Mapk10 Ror2 Nlk Csnk1a1 Mapk8 Rhoa Nfatc2 Rac1 Pparg Tab2 Yes1 Tab1 Camk2a Setdb1 Daam1 Chd7 Flna Dvl1 Dvl2 Arrb2 Dvl3 Wnt5a Rock1 Mapk9 Map3k7 Cthrc1 Fzd2 Fzd5 Fzd7 Fzd6 Prkcz PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling Gng2 Mapk11 Nras Pik3r1 Gnb1 Gnai1 Gnai3 Grb2 Sos1 Rhoa Esr1 Bcar1 Hras Gnaz Nos3 Gnao1 Plcb2 Mmp2 Igf1 Gnai2 Mmp9 Gna11 Gna15 Gna14 Rock2 Gnaq Igf1r Gna13 Akt1 Strn Pelp1 Esr2 Hbegf Pik3ca Msn Plcb3 Kras Shc1 Plcb1 Src REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription Cdx4 Jun Cdx1 Ctnnbip1 Klf4 Pitx2 Bcl9 mt-Co2 Myf5 Mitf Incenp Tcf4 Hbp1 Trrap Mmp2 Mmp9 Hdac2 Axin2 Ctbp1 Cul1 Myc Skp1 Hdac1 Ccn1 Id2 Ctnnb1 Cdh1 Cdkn2a Ccnd2 Btrc Tert Dkk1 Ep300 Lef1 Vcan Ar Ncoa2 Snai2 Apc Tcf7l2 Camk4 Ywhah Ywhag Ywhae Ywhab Neurog1 Sfn Cacna1g Myog Mdfic Dvl3 Ccnd1 Igf2bp1 Cby1 Fgf4 Zcchc12 Ywhaz Tbl1xr1 Kcnip4 Tnik Adcy7 Tle4 Ruvbl2 Med12 Tle2 Tle1 Krt1 Tle5 Dkk4 Chd8 Sall4 T Smarca4 Tcf7 Tcf7l1 Tbl1x Sp5 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway Stat5a Bcl2 Irs2 Crkl Stat1 Ptpn11 Pik3r1 Rap1a Vav2 Gab1 Epor Mapk8 Sh2b3 Grb2 Tec Sos1 Epo Hras Bcl2l1 Lyn Socs3 Plcg2 Inpp5d Ptpn6 Cbl Plcg1 Mapk14 Nfkb1 Stat5b Jak2 Rapgef1 Btk Shc1 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway Gadd45b Traf6 Mapk11 Map3k3 Ccm2 Map3k6 Map3k4 Taok1 Taok3 Map3k10 Traf2 Txn Rac1 Atm Tab2 Tab1 Map3k1 Map3k5 Map3k7 Mapk14 Map2k6 Gadd45a Camk2b Map2k3 Gadd45g C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway Max Supt3 Myc Actl6a Ppp2ca Fbxw7 Taf9 Pml Gsk3b Kat5 Kat2a Supt7l Skp2 Ruvbl2 Ppp2r5a Hbp1 Cdkn2a Trrap Axin1 Zbtb17 Pin1 Ruvbl1 Taf12 Pak2 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway Abcc1 Sphk1 S1pr1 Kdr Plcg1 Gnai1 Gnai3 Mapk1 Mapk3 Rhoa Pdgfrb Ptgs2 Vegfa Pdgfb Rac1 Gnaz Gnao1 Plcb2 Gnai2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network Lck Lyn Lama1 Nrg1 Tgfb1 Tgfb3 Fgr Hck App Prnp Slit2 Gpc1 Serpinc1 Flt1 Fgf2 Vegfa Fgfr1 Smad2 Tgfbr1 Blk Tgfbr2 Fyn Yes1 Src ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins Jun Prkcg Prkcb Fos Pla2g4a Prkce Mapk8 Mapk1 Ednrb Ednra Mapk3 Adcy3 Rhoa Adcy4 Adcy1 Bcar1 Adcy2 Rac1 Adcy8 Adcy5 Adcy6 Adcy9 Plcb2 Edn2 Edn3 Prkch Ptk2b Cysltr2 Cysltr1 Akt1 Col1a2 Slc9a1 Mapk14 Slc9a3 Prkcq Src Edn1 Gnai1 Raf1 Gnai3 Prkca Crk Hras Gna12 Gnaz Gnao1 Gnai2 Map2k2 Gna11 Col3a1 Map2k1 Gna15 Gna14 Gnaq Prkcd Mmp1a Adcy7 Jak2 Plcb3 Plcb1 Trpc6 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network Nrp1 Nrp2 Flt4 Flt1 Pgf Vegfb Vegfa Kdr Vegfd Vegfc NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte Jun Mapk10 Pik3r1 F2rl2 Nck1 Mapk8 Prkci Grb2 Map2k4 Rac1 Fyn Wasl Nck2 Nphs2 Nphs1 Akt1 Cd2ap Kirrel1 Arrb2 Bad Plcg1 Mapk9 Pard6a Pik3cb Pik3ca Tjp1 Prkcz Trpc6 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events Nfkbia Jun Gng2 Pik3r1 Fos Gnb1 Prkce Adcy3 Rhoa Adcy4 Adcy1 Bcar1 Adcy2 Rac1 Adcy8 Adcy5 Adcy6 Adcy9 Mmp2 Pld2 Ptk2b Mmp9 Lyn Prkd1 Gna13 Akt1 Lpar4 Lpar3 Lpar2 Lpar1 Adra1b Src Pxn Trip6 Gab1 Egfr Ptk2 Gnai1 Gnai3 Crk Hras Nherf2 Gna12 Gnaz Gnao1 Gnai2 Gna11 Gna15 Gna14 Gnaq Plcg1 Gsk3b Prkcd Hbegf Adcy7 Tiam1 Nfkb1 Pik3cb Plcb3 Casp3 Arhgef1 Rela BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions Itga7 Itga8 Itga5 Itga6 Itga9 Itga4 Itga1 Itga2 Col18a1 Itga10 Itga11 Itgav Itgb1 Vtn Spp1 Fgg Mdk Jam2 Cd81 Plau Vcam1 Igsf8 Cd14 Thbs1 Thbs2 Fbn1 Npnt Col1a2 Nid1 Cspg4 Plaur Lama4 Fgb Fga Tgfbi Lamb2 Lama2 Lamb3 Lamb1 Lamc2 Vegfa Col11a1 Tnc Col11a2 Fn1 Tgm2 Col2a1 Lamc1 Col3a1 F13a1 Col1a1 Col6a1 Col5a2 Lama1 Lama3 Col4a3 Col4a4 Col7a1 Col6a2 Col4a1 Col5a1 Col4a5 Col6a3 Col4a6 Itga3 Lama5 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling Fgb Fga Itga5 Itgam Elane Egfr Itgav Vtn Pdgfrb Itgb1 Crk Bcar1 Rac1 Itgb2 Fgg Mmp3 Dock1 Fn1 Mmp9 Plau Itgb3 Tgfb1 Hgf Lrp1 Ctsg Pdgfd Itga3 Fpr1 Itgb5 Klk4 Fpr2 Gpld1 Plaur Fpr-s1 Mmp12 Serpine1 Plg Ctrc Mmp13 Vldlr Src VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression Lgals1 Cdkn1b Itga6 Spi1 Hdac3 Itgb1 Ptpa Itgb4 Myc Hdac1 Cdkn2b Foxo3 Wnt5a Creb1 Col1a2 Id2 Rbl1 Tmeff2 Gfi1 Aldh9a1 Clu Fth1 Max Tmem126a Dkk1 Ep300 Sfrp1 Bcl2 Tbp Csde1 Tsc2 Hmgcs2 Cebpd Nfyb Nfya Cebpa Sp1 Nfyc Zfp36l1 Dnmt3a Gtf2h2 Slc11a1 Sfxn3 Ndrg1 Ndrg2 Tjp2 Mxd4 Pdgfrb Brca1 Smad2 Smad3 Ccl5 Smad4 Zbtb17 Cdkn1a Dntt Erbb2 Ccnd1 Ddit3 Cflar Gadd45a Irf8 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network Nrg1 Erbb2 Erbb4 Egfr Ereg Hbegf Nrg2 Btc Areg Nrg4 Nrg3 Tgfa Erbb3 Egf Hsp90aa1 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II Gata1 Gng2 Gnb1 Grk2 Ranbp2 Hdac4 Tuba1b Ube2i Ran Tubb2a Hdac3 Ankra2 Hdac5 Esr1 Bcor Hdac7 Hdac6 Rfxank Hdac9 Mef2c Camk4 Ywhae Gata2 Ywhab Ncor2 Hdac11 Hdac10 Srf Bcl6 Hsp90aa1 Nr3c1 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling Wwp1 Fkbp1a Pml Xiap Eif2a Smurf1 Daxx Tgfb1 Tgfb3 Ppp2ca Arrb2 Ppp1ca Cav1 Ctnnb1 Map3k7 Ccn2 Pard6a Tgfbr1 Tgfbr2 Shc1 Grb2 Sos1 Dynlrb1 Nedd4l Tgfbrap1 Smad2 Zfyve16 Smad3 Ppp2cb Smurf2 Smad4 Tab2 Strap Tab1 Dab2 Dact2 Tgfbr3 Sptbn1 Ywhae Ppp2r2a Pdpk1 Rnf111 Camk2a Ppp1r15a Zfyve9 Smad7 Bambi Yap1 Itch Axin1 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions Cdh1 Itgb7 Itgae JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway Jun Crkl Lcp2 Prkcb Dbnl Map3k8 Grap2 Mapk8 Map3k7 Map4k1 Crk Map2k4 Lat Map3k1 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes Ep300 Chp1 Bcl2 Rcan2 Fkbp1a Prkaca Prkcg Prkcb Prkce Nr4a1 Mef2d Cabin1 Csnk1a1 Ran Mapk8 Akap5 Nfatc1 Prkca Mapk3 Nfatc3 Nfatc2 Crebbp Bax Prkch Camk4 Bcl2l1 Ywhah Map3k1 Ywhag Ywhae Ywhab Fkbp8 Map3k8 Sfn Nup214 Bad Gsk3b Prkcd Kpnb1 Ywhaz Mapk9 Mapk14 Pim1 Casp3 Prkcq Prkcz Rcan1 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Map3k14 Inpp5d Akt1 Ptpn6 Cbl Vav1 Pten Itk Prkcq Shc1 Gab2 Lck Traf6 Lcp2 Ptpn11 Nck1 Rap1a Grap2 Grb2 Prkca Trpv6 Map4k1 Sos1 Csk Hras Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Ptprc Flna Dbnl Map3k8 Sla2 Orai1 Stim1 Cd3e Plcg1 Stk39 Rassf5 Was Ikbkb Cd4 Fyb1 Sh3bp2 H2-Eb1 Ikbkg Cd3g Cd247 Cd3d Cd28 Cd86 Cd80 Kras VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals Rasa1 Ptpn11 Prkaca Prkcb Pik3r1 Nck1 Mapk1 Prkca Flt1 Mapk3 Shc2 Vegfa Nos3 Nrp1 Nrp2 Pdpk1 Pgf Vegfb Akt1 Cd2ap Cbl Hif1a Plcg1 Cav1 Pik3ca Hsp90aa1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events Grb2 Ednra Sos1 Edn1 Hras Egf Mtor Egfr Shc1 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins Gng2 Lgals3 Gli2 Prkaca Shh Gnb1 Smo Ptch1 Pias1 Csnk1a1 Gnai1 Csnk1g3 Csnk1g1 Gnai3 Csnk1g2 Rbbp4 Rbbp7 Crebbp Sin3a Sin3b Gnaz Gnao1 Gnai2 Csnk1d Csnk1e Hdac2 Map2k1 Foxa2 Hdac1 Akt1 Arrb2 Fbxw11 Gsk3b Sap30 Prkcd Rab23 Gli1 Gli3 Mtss1 Sap18b Ift88 Kif3a Stk36 Ift172 Btrc Sufu Spop INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway Rasa1 Irs1 Exoc1 Exoc2 Grb10 Ptpn11 Pik3r1 F2rl2 Eif4ebp1 Exoc7 Nck1 Ins2 Rhoq Trip10 Dok1 Prkci Sh2b2 Insr Grb2 Sos1 Ptpn1 Crk Hras Sgk1 Ptpra Pdpk1 Nck2 Inpp5d Akt1 Cbl Foxo3 Akt2 Cav1 Grb14 Pard6a Pik3ca Exoc3 Sorbs1 Exoc4 Rapgef1 Shc1 Prkcz Exoc5 Exoc6 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network Pdgfa Pdgfd Pdgfrb Pdgfb Pdgfc Pdgfra EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling Efna1 Pak1 Inppl1 Pik3r1 Epha2 Vav2 Cbl Ptk2 Grb2 Tiam1 Rhoa Bcar1 Rac1 Pik3ca Vav3 Arhgap35 Acp1 Shc1 Src ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling Stat3 Stat1 Pik3r1 Mapk8 Mapk1 Sh2d2a Mapk3 Ksr1 Brk1 Map2k4 Rac1 Baiap2 Arpc1b Actr2 Pld1 Actr3 Pld2 Map3k1 Arpc3 Arpc2 Arpc5 Arpc4 Ppp2ca Srf Slc9a1 Smad1 Ppp2r1a Src F2rl2 Gab1 Capn2 Usp6nl Grb2 Prkca Sos1 Hras Ywhah Ywhag Ppp2r2a Ywhae Pdpk1 Ywhab Braf Sfn Elk1 Egr1 Bad Prkcd Ywhaz Mapk9 Dusp1 Kras Mapk7 Prkcz Zfp36 Map3k2 Jun Mylpf Ralgds Arf4 Ppp5c Nras Diaph3 Map2k5 Fos Dusp6 Vav2 Rab5a Rin1 Pebp1 Rps6ka4 Rps6ka5 Atf2 Bcl2l1 Wasl Akt1 Eps8 Mtor Creb1 Iqgap1 Rala Egfr Raf1 Mef2c Egf Map2k2 Map2k1 Rictor Mapkap1 Mlst8 Nckap1 Pik3cb Pik3ca Wasf2 Cyfip2 Rps6ka3 Abi1 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development Ywhae Ppp2r5d Clip1 Katna1 Lrpap1 Pafah1b3 Pafah1b2 Pafah1b1 Cdk5r2 Dab1 Cdk5 Dync1h1 Cdk5r1 Ndel1 Reln Dcx Rhoa Pla2g7 Iqgap1 Rac1 Abl1 Nudc Vldlr Map1b SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL Ccne1 Cdkn1a Egr1 Tuba1b Itga1 Ccna2 Rock1 Mapk1 Mapk3 Rhoa Agt Itgb1 Ptp4a3 Rhoc Bcar1 Ptp4a2 Rabggta Rac1 Rabggtb Atf5 Cdk2 Src EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling Lck Ptpn13 Pik3r1 Mapk8 Itga2b Map2k4 Rac1 Blk Rgs3 Fyn Yes1 Ephb1 Ephb2 Itgb3 Ephb4 Nck2 Lyn Efnb1 Efnb2 Fgr Hck Dnm1 Map3k7 Tiam1 Pik3ca Src VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium Mapk11 Itga5 Pik3r1 Itga4 Itga1 Itga2 Mapk1 Grb2 Mapk3 Sos1 Itgb1 Crk Map2k4 Vegfd Fn1 Vegfc Flt4 Col1a1 Akt1 Creb1 Col1a2 Mapk14 Rps6ka1 Pik3ca Shc1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events Efna1 Pxn Arrb1 Git1 Epha2 Nck1 Egfr Arf6 Itga2b Gulp1 Egf Fbxo8 Cyth2 Ipcef1 Acap2 Gna11 Cyth3 Kif13b Lhcgr Gna15 Itgb3 Iqsec1 Gna14 Arap2 Gnaq Adap1 Hgf Arrb2 Tshr Agtr1a Met Adrb2 Acap1 Src P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network Gata1 Mapk11 Trp63 Mdm2 Pml Jag2 Plk3 Bax Jak1 Pin1 Sirt1 Casp2 Prkacb Pfdn5 Fbxo45 Myc Tuba1a Bub1 Ccne2 Pea15 Il1rap Clca2 Ndufs2 Plk1 Hagh Foxo3 Gramd4 Aen Dcp1b Trp73 Rnf43 Mapk14 Dedd Flot2 Afp Hsf1 Wt1 Bak1 Cdk1 Bub3 Il4ra Serpine1 Ube4b Nsg1 Gdf15 Plpp1 Ep300 Bin1 Sp1 Rad51 Bcl2l11 Nedd4l Chek1 Abl1 Cdk6 Cdk2 Ada Serpina1d Ntrk1 Rack1 Cdkn1a Sfn Wwox Ccna2 Brca2 Kat5 Hey2 Yap1 Rb1 Itch Rchy1 Fasn Rela Fas CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events Gng2 Mapk11 Arrb1 Nras Pik3r1 Gnb1 Gnai1 Raf1 Gnai3 Mapk1 Mapk3 Hras Gnaz Gnao1 Gnai2 Map2k2 Map2k1 Pdpk1 Akt1 Rictor Dnm1 Mtor Ccl11 Mapk14 Cxcl9 Mapkap1 Map2k6 Mlst8 Pik3cb Pik3ca Cxcl11 Map2k3 Cxcl10 Cxcr3 Kras Pf4 Src Cxcl13 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events Il3ra Cnksr1 Stat5a Srp9 Cebpb Ptpn11 Prkaca Pik3r1 Grb2 Csf2rb2 Cish Bcl2l1 Ywhag Prkacb Hdac1 Inpp5d Id1 Ywhaz Pim1 Stat5b Jak2 Pik3ca Osm Shc1 Gab2 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling Grk3 Gng2 Mapk11 Prkaca Prkcg Prkcb Gnb1 Prkce Grk2 Rhoa Rac1 Blk Plcb2 Syk Fyn Yes1 Prkch Lyn Vcam1 Gna13 Akt1 Fgr Hck Pik3cg Pik3r6 Arrb2 Arr3 Mapk14 Icam1 Gnb5 Rab11a Prkcq Src Lck Ptgdr Ptgir Prkg1 Tbxa2r Egfr Prkca Nherf1 Gna12 Nos3 Egf Gnai2 Tgm2 Gna11 Gna15 Gna14 Gnaq Dnm1 Rock1 Prkcd Sele Arhgef1 Prkcz A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling Col17a1 Itga6 Pik3r1 Cd9 Il1a Pmp22 Egfr Lamb2 Lama2 Grb2 Lamb3 Prkca Lamb1 Itgb1 Lamc2 Hras Mst1 Itgb4 Rac1 Erbb3 Casp7 Egf Ywhah Lamc1 Ywhag Ywhae Ywhab Lama1 Lama3 Akt1 Sfn Erbb2 Rxrb Rxra Rxrg Ywhaz Cdh1 Lama5 Met Mst1r Pik3ca Lama4 Shc1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway Nras Eif4ebp1 Clip1 Srebf1 Pml Mapk1 Eif4e Mapk3 Pld1 Pld2 Akt1 Mtor Fbxw11 Btrc Eif4a1 Ccne1 Irs1 Tsc2 Prr5 Rraga Ddit4 Rragb Rragc Rragd Raf1 Tsc1 Eif4b Ulk1 Ulk2 Prkca Rb1cc1 Poldip3 Pdcd4 Hras Atg13 Eef2 Sgk1 Map2k2 Cdk2 Ywhah Ywhag Map2k1 Ywhae Pdpk1 Ywhab Braf Sfn Rictor Rptor Ikbkb Ywhaz Mapkap1 Rps6ka1 Mlst8 Deptor Akt1s1 Eef2k Yy1 Kras Ppargc1a ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway Chuk Nfkb1 Map3k14 Btrc Nfkb2 Relb DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors Tigar Cebpz Nlrc4 E2f2 Prdm1 Prkab1 Ctsd Ppm1j Trp63 Mdm2 Col18a1 Pml Plk3 Mcl1 Spp1 Bax Pou4f1 Trrap Edn2 Pou4f2 Mmp2 Cd82 Taf9 Cav1 Hspa1a Tgfa Pten E2f3 Tsc2 Nfyb Nfya Nfyc Pcna Snai2 Ndrg1 Apc Trp53 Sfn Hgf Bcl2a1d Serpinb5 Carm1 Bdkrb2 Met Gadd45a Igfbp3 Dusp5 Rchy1 Dusp1 Jun Epha2 Perp Cse1l Apaf1 Ccng1 Pidd1 Cop1 Bcl2l1 Hdac2 Casp1 Foxa1 Tfdp1 Trp73 Lif Afp Bcl6 Bak1 Serpine1 Gdf15 Atf3 Dkk1 Ep300 Bcl2 E2f1 Vcan Sp1 Ddit4 Egfr Kat2a Vdr Casp6 Crebbp Drosha Ccnk Pcbp4 Tap1 Hic1 Ppp1r13b Msh2 Tyrp1 Tnfrsf10b Sh2d1a Sesn1 Map4k4 Cdkn1a Rgcc Steap3 Jmy Fdxr Ddx5 Trp53bp2 Btg2 Rrm2b Ddb2 Prmt1 Bcl2l14 Rps27l Gpx1 Bcl2l2 Bnip3l Rnf144b Trp53inp1 Triap1 Irf5 Rb1 Aifm2 Dgcr8 Htt Bid Scn3b Zfp385a Arid3a Smarca4 Pms2 Cx3cl1 Pycard Fas Mlh1 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events Prkaca Prkce Lpar4 Creb1 Adcy3 Adcy7 Adcy4 Rps6ka5 Adcy1 Adcy2 Adcy8 Adcy5 Adcy6 Adcy9 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly Nme1 Snx1 Adam10 Dnm2 Bdnf Gdnf Slit1 Gfra1 Cbll1 Dsp Ctnnd1 Rab5a Cables1 Mep1b Igf2 Egfr Arf6 Cdh2 Robo1 Zbtb33 Hgs Ptpn1 Hras Crebbp Rac1 Abl1 Mmp3 Gna12 Fyn Egf Ntrk2 Rab7 Mmp7 Igf1r Gna13 Ptpn6 Ctnnb1 Cdh1 Tiam1 Rin2 Iqgap1 Met Jup Ret Casp3 Ctnna1 Src AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling Rasa1 Nfkbia Ppp2r5d Git1 Birc5 Prkaca Mdm2 Ran Aurkaip1 Tacc1 Oaz1 Aurkb Cpeb1 Trp53 Ndel1 Ajuba Dlgap5 Tdrd7 Brca1 Fzr1 Pak1 Akt1 Tacc3 Gsk3b Tpx2 Ckap5 Gadd45a Aurka Arhgef7 Cenpa Cdc25b CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling Nfkbia Jun Cblb Stat5a Mapk10 Traf6 Mapk11 Pik3r1 Il4 Mapk8 Cd40lg Traf2 Fcamr Traf3 Cd40 Map2k4 Tdp2 Jak3 Tnfaip3 Bcl2l1 Map3k1 Myc Map3k14 Akt1 Pik3cg Pik3r6 Birc3 Mapk9 Birc2 Mapk14 Nfkb1 Pik3cb Pik3ca Traf1 Rela VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network C3 Ncoa2 Ncoa1 Nr0b1 Ncoa3 Esr2 Smarce1 Ube2m Uba3 Nedd8 Smarcb1 Ddx54 Zfp709 Smarca4 Nr0b2 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases Aurkb Aurka LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events Ezr Mark2 Tsc2 Ctsd Prkaca Tsc1 Trp53 Esr1 Stk11ip Smad4 Stk26 Mark4 Crtc2 Ywhah Stradb Ywhag Smarcd3 Ywhae Strada Cab39 Etv4 Myc Ywhab Stk11 Sik3 Sik2 Sik1 Sfn Psen2 Brsk2 Brsk1 Mtor Creb1 Gsk3b Rptor Cdc37 Ywhaz Mlst8 Akt1s1 Hsp90aa1 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway Ephb2 Ephb3 Ephb4 Efnb1 Efnb2 Ephb1 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway Map3k2 Nras Map2k5 Fos Rap1a Cdk5 Raf1 Mapkapk2 Mapk1 Cdk5r1 Mapk3 Ntf3 Rps6ka5 Hras Rit1 Mef2c Rit2 Ehd4 Map2k1 Trpv1 Braf Rap1b Elk1 Egr1 Creb1 Srf Prkcd Mapk14 Map2k6 Rps6ka1 Map2k3 Kras Mapk7 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway Map3k3 Stat1 Nsmaf Madd Tnfrsf1a Sqstm1 Bag4 Tradd Prkci Traf2 Txn Tnfaip3 Tab2 Smpd2 Tab1 Map3k1 Map4k4 Rack1 Chuk Nrk Map3k5 Map4k5 Tnf Map4k3 Cav1 Birc3 Adam17 Tnfrsf1b Ikbkb Cyld Birc2 Map3k7 Map4k2 Ikbkg Rffl Map2k7 Tnik Nfkb1 Casp8 Smpd1 Map2k3 Traf1 Ripk1 Prkcz Rela Fadd FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks Cpt1a Bdh1 Foxf1 Cebpb Abcc8 Kcnj11 Alb Cebpd Apoa1 Hnf1a Cebpa Sp1 Cpt1b Ins2 Cpt1c Hadh Dlk1 G6pc1 Hnf4a Foxa1 Foxa2 Foxa3 Akt1 Creb1 Pklr Tat Afp Aldob Nkx2-1 Acadvl F2 Alas1 Tfrc Ttr Igfbp1 Ucp2 Slc2a2 Nf1 Pck1 Pdx1 Nr3c1 Acadm Gck CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events Jun Rasgrf1 Diaph3 Pik3r1 Prkce Vav2 Mapk8 Mapk1 Mapk3 Arhgdia Bcar1 Map2k4 Atf2 Rac1 Baiap2 Iqgap3 Arpc1b Actr2 Pld1 Actr3 Yes1 Pak2 Map3k1 Arpc3 Wasl Arpc2 Pak1 Arpc5 Arpc4 Map3k11 Eps8 Cbl Mtor Ctnnb1 Mapk14 Cdh1 Pard6a Iqgap1 Cfl1 Map2k3 Myl2 Ctnna1 Limk1 Arhgef7 Limk2 Src Arhgef6 F2rl2 Exoc7 Cdc42bpa Septin2 Pax6 Raf1 Hes5 Tnk2 Apc Hras Braf Gsk3b Mapk9 Map2k7 Map2k6 Tiam1 Pak4 Pik3ca Dlg1 Prkcz CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events Stat5a Gng2 Stat3 Stat1 Pik3r1 Gnb1 Cxcl12 Grk2 Hgs Rhoa Bcar1 Rac1 Blk Plcb2 Fyn Yes1 Ptk2b Mmp9 Pak1 Lyn Inpp5d Gna13 Akt1 Ptpn6 Fgr Hck Pik3cg Pik3r6 Arrb2 Mtor Foxo1 Vav1 Arr3 Stat5b Cfl1 Limk1 Src Lck Pxn Ptpn11 Cxcr4 Ptk2 Gnai1 Gnai3 Rgs1 Ubqln1 Vps4a Vps4b Crk Grk6 Stat2 Rhoc Ralb Csk Rhob Pag1 Gnaz Gnao1 Gnai2 Pdpk1 Rack1 Ptprc Rap1b Rictor Dnm1 Bad Cd3e Cd4 H2-Eb1 Ssh1 Mapkap1 Mlst8 Cd3g Cd247 Jak2 Cd3d Pik3cb Itch Pik3ca Plcb3 Plcb1 Prkcz P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases Ywhag Ywhae Tcf3 Mapk11 Ywhab Tsc2 Sfn Hspb1 Creb1 Mapkapk3 Srf Raf1 Mapkapk2 Ywhaz Mapk14 Etv1 Lsp1 Cdc25b Ywhah Th PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling Jun Dkk1 Ppp2r5d Adam10 Psen1 Ppard Nlk Fos Hnf1a Dtx1 Dll1 Csnk1a1 Wnt1 Apc Mapk1 Mapk3 Crebbp Nkd1 Dkk2 Frat1 Tab1 Ctbp1 Myc Hdac1 Dvl1 Lrp6 Ccnd1 Wif1 Fbxw11 Gsk3b Ctnnb1 Map3k7 Fzd1 Tle1 Kremen2 Tle5 Btrc Rbpj Axin1 Ncstn Notch1 Aph1b VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms Ep300 Wwp1 Mfge8 Shh Sp1 Cables1 Perp Trp63 Mdm2 Pml Jag1 Vdr Itgb4 Hbp1 Abl1 Bax Dhrs3 Traf4 Ogg1 Spata18 Tfap2c Ada Nqo1 Smarcd3 Evpl Ssrp1 Dicer1 Cdkn1a Chuk Fdxr Clca2 Plk1 Serpinb5 Aen Prkcd Ikbkb Egr2 Flot2 Itga3 Cdkn2a Gadd45a Igfbp3 Itch Btrc Gdf15 Fas IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway Ep300 Cebpb Il1b Crkl Stat3 Stat1 Ptpn11 Pik3r1 Rap1a Pias1 Ifng Mapk1 Socs1 Ptpn2 Mapk3 Ifngr1 Crebbp Jak1 Map3k1 Pias4 Casp1 Map2k1 Dapk1 Camk2a Ptges2 Irf9 Smad7 Akt1 Map3k11 Rap1b Cbl Camk2d Mtor Prkcd Camk2g Jak2 Pik3ca Camk2b Irf1 Rapgef1 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway Pip5k1a Ap2m1 Gbf1 Uso1 Gga3 Kdelr1 Asap1 Ap2a1 Arfip2 Gosr2 Cltb Copa Arfgap1 Cd4 Clta Rac1 Arf1 Cyth2 Pld2 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events Jun Myd88 Traf6 Il1b Il1r1 Map3k3 Irak4 Pik3r1 Il1a Sqstm1 Mapk8 Prkci Tab2 Tab1 Casp1 Chuk Il1rap Ikbkb Ube2v1 Map3k7 Ticam2 Ikbkg Irak3 Erc1 Map2k6 Tollip Nfkb1 Il1r2 Il1rn Ube2n Pik3ca Prkcz Irak1 Rela GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network Pbx1 Jun Krt14 Stat5a Smarcc2 Mapk10 Mapk11 Pomc Ppp5c Krt5 Stat1 Prkaca Fos Nr4a1 Il2 Il4 Mdm2 Pou2f1 Ifng Cdk5 Mapk8 Mapk1 Cdk5r1 Nfatc1 Spi1 Csf2 Mapk3 Fgg Bax Hdac2 Prkacb Hdac1 Akt1 Creb1 Mapk14 Afp Stat5b Icam1 Gata3 Hsp90aa1 Nr3c1 Ep300 Tbp Ncoa2 Ncoa1 Il5 Prl Csn2 Trp53 Crebbp Sgk1 Ywhah Cdkn1a Sfn Egr1 Gsk3b Il6 Mapk9 Il13 Mmp1a Nfkb1 Nr1i3 Tsg101 Smarcc1 Kmt5b Sele Fkbp5 Tbx21 Vipr1 Pou1f1 Irf1 Smarca4 Smarcd1 Fkbp4 Cga Rela Pck2 Krt17 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 Cblb Stambp Sh3gl2 Amph Chmp3 Epn1 Nras Pik3r1 Zfyve28 Rab5a Ptk2 Egfr Raf1 Grb2 Hgs Sos1 Ube2d3 Hras Ube2d1 Spry2 Egf Usp8 Synj1 Cbl Dnm1 Itsn1 Lrig1 Sh3kbp1 Eps15 Tsg101 Pik3cb Pik3ca Kras Arhgef7 Shc1 Src E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network Cdkn1b E2f2 Uxt Ces1d Tfdp2 Cdkn2c Cbx5 Tyms Mybl2 Sult2a1 Ccnd3 Ranbp1 Mcm3 Ces2h Ces4a Prmt5 Pola1 Apaf1 Dhfr Rybp Orc1 Mcl1 Ces3b Hbp1 Rrm1 Ces5a Rrm2 E2f6 Trrap Casp7 E2f7 Wasf1 Sirt1 Cdc6 Plau Myc Hdac1 Ccne2 Cdc25a Tfdp1 Trp73 Tfe3 Rbl1 Cdkn2a Cdk1 Serpine1 Xrcc1 E2f3 Tk1 Ccne1 Smarca2 Ep300 E2f1 Trim28 Cebpa Sp1 Kat2b Kat2a Rbbp4 Topbp1 Brca1 Crebbp Atm Rbl2 Hic1 Cdk2 E2f4 Cdkn1a E2f5 Ccna2 Rb1 Rbbp8 Yy1 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway Nfkbia Ripk2 Traf6 Chuk Bcl10 Tnf Tnfrsf1a Ran Ikbkb Cyld Birc2 Ikbkg Erc1 Prkca Nfkb1 Ube2d3 Atm Btrc Tnfaip3 Nod2 Rela Malt1 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling Epha5 Fyn Efna5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells Nras Prkcb Prkce Rasgrp1 Rasgrp2 Fyn Chuk Map3k14 Akt1 Ptpn6 Cbl Vav1 Prkcq Shc1 B2m Lck Traf6 Lcp2 Cd8a Cd8b1 Rap1a Grap2 Grb2 Prkca Trpv6 Sos1 Csk Hras H2-Q10 Pag1 Lat Zap70 Malt1 Card11 Pdpk1 Bcl10 Ptprc Map3k8 Orai1 Stim1 Cd3e Plcg1 Rassf5 Ikbkb Ikbkg Cd3g Cd247 Prf1 Cd3d Cd28 Cd86 Cd80 Kras REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase Jun Cdkn1b Ube3a Fos Il2 Ifng Mapk1 Smg5 Mapk3 Sin3a Sin3b Terf1 Smg6 Hdac2 Tinf2 Parp2 Tnks Dkc1 Pot1 Myc Pif1 Hdac1 Wrn Tgfb1 Acd Akt1 Znfx1 Terf2ip Hnrnpc Pinx1 Mtor Sap30 Mxd1 Sap18b Terf2 Wt1 Hsp90aa1 Tert Max Ifnar2 E2f1 Mre11a Nbn Sp1 Sp3 Egfr Rad50 Rbbp4 Rbbp7 Xrcc6 Esr1 Xrcc5 Blm Atm Abl1 Rad9a Smad3 Egf Ywhae Nr2f2 Hus1 Ccnd1 Rad1 Nfkb1 Irf1 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein Jun Cdkn1b Mapk11 E2f2 Mitf Mdm2 Ccnd3 Spi1 Csf2 Hdac3 Atf2 Smarcb1 Pparg Sirt1 Ctbp1 Hdac1 Ppp2ca Tfdp1 Suv39h1 Brd2 Pax3 Aatf Rbp2 Atf7 Mapk14 Ckm Dnmt1 Taf1 Cdkn2a Ccnd2 Ubtf E2f3 Myod1 Ccne1 Ep300 Tbp Cebpb E2f1 Elf1 Cebpd Cebpa Gsc Runx2 Raf1 Cbx4 Rbbp4 Skp2 Crebbp Abl1 Cdk6 Mef2c Sftpd Cdk4 Cdk2 E2f4 Cdkn1a Ccna2 Ccnd1 Mapk9 Met Rb1 Tgfb2 Smarca4 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling Pias4 Ctdsp1 Nup214 Ube2i Kpnb1 Mapk1 Mapk3 Ppm1a Nup153 Ctdspl Smad2 Tgfbrap1 Smad3 Smad4 Map3k1 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network Jun Fos Cxcl12 Npm1 Ets1 Hdac7 Mcl1 Itgb2 Hnf4a Gata2 Tff3 Akt1 Ldha Hmox1 Creb1 Id2 EG433182 Plin2 Tfrc Adm Serpine1 Cp Igfbp1 Pfkfb3 Eng Nt5e Car9 Pgm1 Fech Pkm Gck Tert Aldoa Ep300 Abcb1a Pfkl Rora Hk2 Edn1 Ncoa2 Hk1 Ncoa1 Bhlhe41 Sp1 Cxcr4 Ndrg1 Cops5 Epo Bhlhe40 Vegfa Crebbp Furin Egln3 Smad3 Lep Cited2 Smad4 Pgk1 Slc2a1 Abcg2 Tf Arnt Hif1a Nos2 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway Crkl Pik3r1 Grin2a Mapk8ip1 Rap1a Lrpap1 Pafah1b1 Dab1 Cdk5 Mapk8 Cdk5r1 Reln Itgb1 Fyn Map1b Nck2 Arhgef2 Akt1 Map3k11 Cbl Gsk3b Map2k7 Itga3 Grin2b Pik3ca Vldlr Rapgef1 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway Tnfrsf10b Chuk Pik3r1 Dap3 Tnfsf10 Ikbkb Mapk8 Tradd Mapk1 Ikbkg Traf2 Mapk3 Cflar Map2k4 Pik3cb Pik3ca Casp8 Smpd1 Ripk1 Map3k1 Fadd RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling Mapk9 Mapk14 Gng2 Mapk11 Gnb1 Crh Mapk8 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP Stat5a Stat3 Stat1 Pik3r1 Kdr Eif2ak2 Ins2 Csf1r Itga1 Gab1 Lman1 Pias1 Egfr Rab4a Csf1 Insr Grb2 Stat6 Ptpn2 Sos1 Ptpn1 Pdgfrb Itgb1 Eif2a Vegfa Crebbp Pdgfb Jak3 Jak1 Egf Hgf Kpnb1 Stat5b Met Pik3cb Pik3ca Shc1 Src BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling Ctdsp1 Grem1 Ahsg Sostdc1 Mapk1 Rgmb Xiap Rgma Hjv Chrd Cer1 Bmp4 Fst Nog Bmpr1a Ski Bmp6 Zfyve16 Bmp2 Smad6 Smad4 Smurf2 Tab2 Tab1 Smurf1 Ppp1r15a Smad7 Bambi Nup214 Ppp1ca Gsk3b Bmpr2 Map3k7 Smad1 Smad9 Ppm1a Bmp7 Ctdspl Smad5 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events Gna15 Gna14 Gng2 Rock2 Gnaq Gna13 F2rl2 Gnb1 Rock1 Rhoa F2 Plcb2 F2rl3 Myl2 Gna11 FSH%NETPATH%FSH FSH Map2k2 Grk4 Fshb Fshr Akt2 Grk6 Cga Appl1 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog Med23 Med12 Med1 Dhh Hhip Ihh Stk36 Prkaca Ctnnb1 Gli1 Med6 Gli2 Cdk8 Ywhae Grk2 Ptch2 Sap18b Ptch1 Dyrk1a Sufu Boc Arrb2 Gas1 Kif27 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor Creb1 Ar Hdac1 Hspb1 Akt1 Pik3r1 Ptk2 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor Runx2 Rb1 Kat2b Tgfbr3 Prkar2a Trim33 Pml Ski Map2k3 Samd3 Mef2a Mef2c Brca1 Zfyve9 E2f4 Cdkn1a Tgfbr2 Arrb2 Ar Hdac1 Akt1 Pik3r1 Ptk2 Atf2 Ccne1 Fkbp1a Stambpl1 Mapk1 Irf2bp1 Dynlrb2 Ets1 Dynlrb1 Kpnb1 Mapk3 Vps39 Ube2i Myc Sox9 Skp1 Pdk1 Pard6a Ctnna2 Ctnna1 Dcp1a Rbx1 Eid2 Ube2d3 Ube2d1 Nup153 Trp73 Sik1 Btrc Cdc25a Atf3 Jund Pxn Sdc2 Anapc5 Snip1 Anapc4 Anapc1 Dab2 Anapc2 Snx4 Trap1 Snx2 Tgfb1 Snx1 Tgfb2 Tgfb3 Sp1 Cited1 Anapc7 Snx6 Jun Cops5 Pik3ca Ccnd1 Vdr Trp53 Cav1 Sptbn1 Esr1 Ppp2r2a Stk11 Hspa8 Map4k1 Ppp1r15a Nup214 Wwtr1 Sparc Cdk6 Smad4 Fnta Cdk4 Cul1 Cdc16 Tab1 Junb Daxx Smad6 Hnf4a Ing2 Xpo1 Xpo4 Pdpk1 Ctcf Foxo4 Tfdp2 Tfdp1 Foxo3 Zfyve16 Foxo1 Ccnb2 Ewsr1 Fos Nme1 Pja1 Zeb1 Gsk3b Rbl2 Zeb2 Anapc10 Smurf1 Crk Pik3r2 Eng Yap1 Stk11ip Hoxa9 Nfyb Eif3i Nfya Ppm1a Prkar1b Nfyc Map2k6 Bcar1 Fzr1 Ncoa1 Ap2b1 Fosb Runx3 Cd44 TCR%NETPATH%TCR TCR Map2k2 Ctnnb1 Dyrk1a Creb1 Akt1 Pik3r1 Ptk2 Atf2 Mapk1 Mapk3 Pxn Gsk3b Crk Pik3r2 Pard3 Prkd1 Prkd2 Eno2 Crkl Cd2ap Acta1 Plcg1 Cblb Plcg2 Ly9 Wipf1 Prkcd Itsn2 Rasgrp1 Rasgrp2 Vasp Arhgef7 Arhgef6 Rasa1 Txk Arhgef2 Unc119 Cabin1 Pttg1ip Pik3ap1 Bcl10 Grap Lnpep Pag1 Lyn Egr1 Nfkbib Fyb1 Tfrc Pik3c2b Cgn Homer3 Nfkbia Crebbp Kirrel1 Slamf6 Cyfip1 Grb2 Ada Ikbkb Itk Gdi2 Shb Tsg101 Dyrk1b Cltc Cd28 Nfkb1 Pgam1 Jak3 Ptprh Vav3 Rap1a Diaph1 Syk Skap2 Skap1 Gab2 Vav1 Vav2 Card11 Bdh1 Ldha Ldhb Tuba4a Prpf4b Icos Zdhhc17 Golga5 Ctla4 Was Cd3g Actr10 Cd3e Cd3d Dusp3 Def6 Pak1 Nfam1 Caskin2 Cct8 Dpysl2 Git2 Ahcy Grap2 Elp3 Mpzl1 Map2k1 Rapgef1 Hnrnph3 Nedd9 Stat1 Dbnl Mapk7 Sh2d3c Mapk8 Tuba1a Sla Map3k8 R3hcc1l Sit1 Dgka Erbin Cd86 Sdcbp Cd84 Sh2d2a Cd82 Cd80 Snrnp70 Lax1 Hsp90ab1 Rela Mtmr10 Dok1 Dok2 Hgs Fcrl5 Stk39 Pkp4 Flnb Anxa2 Raf1 Inpp5d Shc1 Pi4ka Stk4 Acly Ripk2 Elmo1 Abl1 Bmf Ptprc Tubb5 Ppp3cb Eprs1 Ptpra Pstpip1 Acbd6 Fer Ogn Cdk1 Lat Itpr1 Zap70 Wdr1 Arhgdib Ddx3x Txnrd1 Pecam1 Nfatc1 Hdac7 Acp1 Pgm1 Nck1 Nfatc2 Stam2 Anxa11 Msl2 Adam9 Dnm2 Epha3 Ddx49 Pkm Lck Evl Sos2 Lcp2 Sos1 Lpxn Ywhaz Eif3m Ubash3b Atp1a1 Src Atp1a3 Ptpn6 Trim25 Cbl Cebpb Dock2 Cd2 Muc1 Cd4 Trat1 Cd5 G6pdx Cd7 Ptpn11 Ptpn12 Mapk14 Arhgap35 Dnajb1 Ptk2b Sh2b3 Sh3bp2 Tec Khdrbs1 Ptpn22 Chuk Ran Mapk11 LEPTIN%NETPATH%LEPTIN Leptin Runx2 Esr1 Akt1 Src Ptk2 Jak3 Mapk1 Shc1 Plcg1 Plcg2 Khdrbs1 Chuk Crp Erbb2 Irs1 Irs4 Eif4ebp1 Pde3a Socs7 Gsk3b Prkaa1 Prkaa2 Gnaq Slc2a4 Fyn Jak1 Nos3 Cfl2 Sh2b1 Egfr Eif4e Stat1 Gsk3a Cdk5 Itgb5 Mapk8 Lep Nfkbia Limk1 Prkce Rps6ka2 Acacb Ncoa1 Igf1r Grb2 Ikbkb KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor Matk Socs6 Ptpru Gys1 Akt1 Jak2 Sh3kbp1 Pik3r1 Mad2l1 Atf2 Rela Fgr Hck Prkcb Rps6ka1 Mapk1 Kit Tnfrsf10b Prkca Il7r Spred1 Ezr Raf1 Spred2 Inpp5d Grb7 Ep300 Mtor Crkl Epor Csf2rb2 Mapk12 Yes1 Cblb Abl1 Kitlg Rdx Msn Wipf1 Stat5a Stat5b Fes Cdk2 Hras Rasa1 Grap Jun Pik3ca Sos1 Cltc Src Jak3 Ptpn11 Mapk14 Tec Was Eif4ebp1 Gsk3b Crk Fyn Stat1 Mapk8 Socs1 Mitf Socs5 Socs4 BCR%NETPATH%BCR BCR Rb1 Hck Prkcb Rps6ka1 Prkd1 Crkl Plcg1 Prkcd Cdk2 Cd72 Stap1 Elk1 Sla2 Rasa1 Chst15 Malt1 Prkcq Gtf2i Tcl1 Rasgrp3 Btk Bcl10 Pip4k2b Pip4k2c Pip4k2a Cd79a Lyn Cd79b Pik3cg Cdk7 Bcl6 Btla Hnrnpk Itpr2 Bank1 Nfatc3 Cd22 Plekha2 Plekha1 Grb2 Hcls1 Lat2 Ikbkb Blnk Itk Ptpn18 Ccl4 Casp7 Mapkapk2 Casp9 Sh2b2 Fcgr2b Bax Stat3 Pip5k1c Pip5k1b Pip5k1a Vav1 Card11 Rapgef1 Ctnnb1 Nedd9 Stat1 Creb1 Akt1 Ptk2 Atf2 Rela Dok1 Mapk1 Shc1 Itpr1 Zap70 Nck1 Nfatc2 Jun Lck Sos2 Sos1 Map4k1 Ptpn6 Junb Mapk14 Pdpk1 Sh3bp2 Tec Foxo3 Chuk Fos Eif4ebp1 Gsk3b Crk Fyn Pik3r2 Gsk3a Bcar1 Fosb TNFALPHA%NETPATH%TNFALPHA TNFalpha Prkca Ep300 Stat5a Gtf2i Casp7 Mapkapk2 Bax Nkiras1 Rpl4 Nkiras2 Erbb3 Tbkbp1 Trib3 Rps11 Tbk1 Tnfrsf11a Dpf2 Kcnq1 Tax1bp1 Polr1b Polr1c Txnip Polr1a Polr1d Polr1e Actl6a Smarce1 Tifa Cdc37 Cdc34 Rffl Rasa3 Akt2 Nfkbiz Txn Glg1 Sec16a Cradd Dcaf7 Nfkbie Diablo Rel Faf1 Ikbkg Tnfrsf8 Ikbke Mark2 Tnfrsf1b Rfk Akap8 Psmb5 Ywhae Gab1 Bcl2l1 Rack1 Fkbp5 Fbxw7 Fadd Smpd3 Psmc2 Psmc1 Psmc3 Map2k5 Creb1 Itch Bid Hdac1 Commd1 Hspb1 Akt1 Trpc4ap Psmd7 Ptk2 Psmd6 Fancd2 Psmd3 Psmd2 Elp1 Psmd1 Mapk1 Ktn1 Pkn1 Map3k11 Lrpprc Mapk9 Brinp1 Mapk3 Nr2c2 Nlrp4e Ube2i Tnf Map3k5 Skp1 Hsp90aa1 Pdk1 Fbl Ppp1r12a Unc5cl Ppp1r13l Usp2 Xiap Fbxw11 Txlna Ube2d3 Tank Relb Map3k3 Map3k2 Btrc Rxra Flna Papola Bag4 Ripk3 G3bp2 Cops3 Kpna6 Kpna3 Cdk9 Zbtb17 Cyba Ccnt1 Trap1 Bcl3 Tab3 Tab2 Traf7 Mcm7 Traf4 Pfdn2 Traf6 Traf5 Birc3 Jun Birc2 Ywhah Ywhag Psmd12 Copb2 Hdac2 Cav1 Smarcb1 Ywhab Psmd13 Alpl Rasal2 Rnf11 Hdac6 Iqgap2 Peg3 Bcl7a Ppp6c Nupr1 Rps6ka5 Mcm5 Smarca4 Cul1 Tnip2 Polr2h Tab1 Pdcd2 Junb Nsmaf Zfand5 Cflar Casp3 Romo1 Casp2 Trim32 Spag9 Usp11 Glb1 Smarcc2 Prc1 Smarcc1 Rnf25 Foxo1 Mtif2 Map2k6 Rb1 Pml Nfkbia Crebbp Grb2 Nfkb1 Pak1 Stat1 Mapk8 Map3k8 Hsp90ab1 Dok1 Ddx3x Sos2 Sos1 Ywhaz Src Ptpn11 Mapk14 Irs1 Egfr ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin Lamc1 Ar Lamc2 Vim Akt1 Pik3r1 Ptk2 Mapk1 Prkca Mapk3 Shc1 Mtor Yes1 Abl1 Prkcd Trp73 Pik3cg Jun Ywhah Pik3ca Grb2 Ywhab Ywhaz Src Ptpn11 Mapk14 Casp3 Clca1 Erbb2 Rpsa Irs1 Irs2 Fos Rhoa Pak1 Rac1 Eif4ebp1 Plec Dsp Lama5 Cd151 Itgb4 Lama2 Lama3 Fyn Mst1r Pik3r2 Met Mylk3 Pik3r3 Egfr Col17a1 Eif4e Itga6 Ntn1 Ephb2 Ywhae Lamb2 Gab1 Lamb3 Sfn Lamb1 Pik3cb Pik3cd Rtkn Bad Erbin Smad2 Smad3 Eif6 WNT%NETPATH%WNT Wnt Map3k7 Sox1 Akt1 Ctbp1 Wnt5a Cdh1 Setdb1 Pi4k2a Prkcb Ppp1ca Sfrp2 Ppp2ca Sfrp1 Prkca Daam1 Dkk1 Mesd Pax2 Prkcg Frzb Dixdc1 Chd7 Axin1 Ror1 Lef1 Yes1 Lrp1 Arhgef4 Csnk1a1 Nlk Prkcd Lrp5 Gpc3 Dvl3 Wnt2 Wnt1 Tcf7l2 Wnt3 Fzd1 Jup Fzd5 Fzd4 Fzd7 Fzd6 Kremen1 Fzd9 Smad1 Bcl9 Pin1 Tcf4 Nfatc2 Jun Ccnd1 Ywhab Pip5k1b Cdk6 Rhoa Rac1 Prkaca Mark2 Mapk8 Arrb2 IL6%NETPATH%IL6 IL6 Ar Rb1 Hdac1 Map3k7 Hspb1 Akt1 Pik3r1 Fgr Hck Mapk1 Mapk3 Shc1 Ep300 Hsp90aa1 Plcg1 Nlk Stat5a Prkcd Stat5b Btk Cdk9 Lyn Socs3 Map3k4 Pias3 Cd40 Tyk2 Sgk1 Il6st Hnrnpa1 Il6 Crebbp Bmx Jun Eif2a Map2k4 Il6ra Grb2 Nfkb1 Stat3 Cbl Erbb3 Gab2 Vav1 Ptpn11 Daxx Mapk14 Ptk2b Foxo4 Foxo3 Foxo1 Map2k2 Erbb2 Fos Rac1 Eif4ebp1 Gsk3b Fyn Jak1 Pik3r2 Map2k1 Eif4e Stat1 Mapk8 Gab1 Map2k6 Ncoa1 Bad TSH%NETPATH%TSH TSH Creb1 Gnao1 Tshr Hspa5 Canx Atp1a1 Gnai2 Gnai1 Scrib Calr Map2k3 Gnai3 Gnaq Mapk3 Raf1 Lep Map2k6 Igf1r Gna12 Gna11 Ikbkb Gna13 EGFR1%NETPATH%EGFR1 EGFR1 Huwe1 Tjp2 Cavin1 Cavin2 Cc2d1a Prkx Krt6a Ap2a1 Vcl Cysrt1 Stambp Pld1 Lpp Pld2 Elmo2 Dynll1 Tom1l2 Tom1l1 Efnb2 Cav2 Ripk1 Sirpa Ralgds Dlg3 Crim1 Ddx6 Afap1l2 Tgif1 Sfpq Dapp1 Asap1 Iqgap1 Asap3 Anks1 Baiap2 Lsr Epn1 Rps6ka3 Dyrk4 Epn3 Usp31 Dyrk3 Dock4 Elf3 Klf11 Aplp2 Myh9 Tnip1 Mvp Eif4g1 Dock1 Phldb2 Rgs16 Kras Mta2 Snrpd2 Egf Spry2 Spry3 Spry1 Reps2 Spry4 Pebp1 Ptpn23 Zpr1 Map2k2 Appl1 Dyrk1a Creb1 Hdac1 Pik3r1 Ptk2 Mapk1 Myc Jund Dab2 Sp1 Jun Pik3ca Trp53 Cav1 Stk11 Pdpk1 Foxo4 Zfyve16 Foxo1 Fos Gsk3b Crk Pik3r2 Ap2b1 Map2k3 Pard3 Prkd1 Crkl Plcg1 Cblb Plcg2 Prkcd Itsn2 Vasp Arhgef7 Pttg1ip Lyn Tfrc Pik3c2b Kirrel1 Shb Dyrk1b Cltc Nfkb1 Pgam1 Vav1 Vav2 Ldha Prpf4b Pak1 Caskin2 Git2 Mpzl1 Map2k1 Nedd9 Mapk7 Mapk8 Erbin Sdcbp Rela Dok1 Dok2 Pkp4 Flnb Raf1 Abl1 Ptpra Cdk1 Ddx3x Acp1 Nck1 Adam9 Pkm Lck Ywhaz Ubash3b Atp1a1 Ptpn6 Cebpb Ptpn12 Mapk14 Arhgap35 Ptk2b Khdrbs1 Erbb2 Eif4ebp1 Prkaa1 Prkaa2 Fyn Jak1 Nos3 Sh2b1 Egfr Gsk3a Cdk5 Rps6ka2 Socs1 Jak2 Sh3kbp1 Rps6ka1 Kit Prkca Grb7 Mtor Stat5a Stat5b Cdk2 Hras Elk1 Pik3cg Ptpn18 Casp9 Erbb3 Gab1 Itch Mapk9 Map3k3 Ywhab Rps6ka5 Irs2 Rhoa Rac1 Plec Dsp Itgb4 Met Pik3r3 Col17a1 Ephb2 Pik3cb Pik3cd Bad Smad2 Smad3 Vim Ctbp1 Cdh1 Prkcg Arhgef4 Jup Socs3 Map3k4 Pias3 Tyk2 Hnrnpa1 Scrib Il17rd Myl12b Mprip Elk4 Gja1 Tfg Ralb Otud6b Araf Frs2 Frs3 Arhgap5 Prkci S100a14 Arap1 Zdhhc5 S100a10 S100a11 Snca Trip6 Flot1 Errfi1 Myo6 Garem1 mt-Co2 Antxr1 Arf4 Braf Clta Cyld Ahnak Snx33 Tkt Baiap2l1 Prkar1a Rbck1 Htt Appl2 EG433182 Stx4 Inppl1 Pygb Pdzd11 Gsn Ap2s1 Mcf2 Eps15l1 Esyt1 Eppk1 Ensa Stat2 Pkn2 Frk Hipk2 Map3k14 Hipk3 Marveld2 Eef1a2 Atxn2 Grb14 Rictor Grb10 Phpt1 Stip1 Cdh3 Cdh2 Plekhn1 Cfl1 Magi1 Hat1 Pkp2 Hnrnpdl Anxa4 Ldlr Pkp3 Anxa1 Map4k5 Rab5a Ppp1r14b Itga3 Pdgfrb Serpinb3d Abl2 Slc38a2 Ptpre Tnk2 Alb Bcl2 Pdlim1 Sh3bgrl Pdlim4 Nck2 Slc12a7 Sh3gl3 Epha1 Epha2 Epha4 Itgb1 Dsg2 Ctnnal1 Cd59b Wbp2 Sri Ephb1 Cebpa Ephb3 Ephb4 Ahcyl1 Ptpn1 Slitrk6 Csk Arhgap32 Rbbp7 Tagln2 Pten Ralbp1 Bcar3 Slc25a5 Arhgap42 App Spart Nectin1 Rps10 Tns4 Scamp3 Tns3 Tns2 Tns1 Krt8 Cblc Krt7 Krt5 Phlpp1 Actb Actr2 Actr3 Pfn1 Tln1 Rin1 H3c8 Hnrnpr Sdc4 Sdc3 Insr Stam Atp5f1c Usp6nl Slc5a5 Snx5 Tollip Pdcd6ip Smu1 Etl4 Sdc1 Hip1 Adam17 Ptprr Ptprk Ptprf Dcbld2 Rps27l Git1 Cdv3 Laptm4a Plekha6 Plekha5 Mink1 Actn1 Actn4 Plscr1 Gprc5a Map2k7 Aldoa Ncoa3 Limd1 Cstb Krt18 Krt17 Racgap1 Wasl Cttn Axl Ctnnd1 ID%NETPATH%ID ID Map2k2 Rb1 Psmd4 Fhl2 Tcf7l2 Pax5 Elk1 Elk3 Rbl1 Atf3 Hes1 Id3 Rbl2 Smurf2 Tcf3 Myf5 Mapk1 Elk4 Map2k1 Mapk3 Raf1 Smad3 Cdk2 IL9%NETPATH%IL9 IL9 Mapk3 Tyk2 Kat5 Mapk1 Stat5a Stat6 Stat5b Il9r IL3%NETPATH%IL3 IL3 Creb1 Ywhab Ywhaz Pik3r1 Nfkb1 Ptk2 Ptpn6 Dok1 Prkcb Mapk1 Ppp2ca Prkca Socs2 Bcl2l11 Kcnip3 Gab2 Rara Inpp5d Slc2a1 Shc1 Gata2 Crkl Csf2rb2 Ptprc Fes Foxo1 Hras Rxra Gsk3b Crk Pik3r2 Map2k1 Lyn Prkaca Socs3 Gsk3a Gab1 Bcl2l1 Rack1 Pik3cd Bad IL5%NETPATH%IL5 IL5 Ywhaz Nfkb1 Bax Atf2 Stat3 Hck Cbl Rps6ka1 Syk Raf1 Shc1 Ptpn11 Alox5 Il2rb Crkl Mapk14 Pla2g4a Il5 Sox4 Ptk2b Il5ra Stat5a Stat5b Prkcd Foxo3 Map2k2 Hras Elk1 Unc119 Gsk3b Jak1 Lyn Rapgef1 Ctnnb1 Pik3cg Stat1 Gsk3a Nfkbia Dnm2 Rack1 Jun Socs1 Hcls1 Grb2 Sdcbp Sos1 IL4%NETPATH%IL4 IL4 Akt1 Jak2 Ptk2 Atf2 Mapk1 Ets1 Mapk3 Inpp5d Shc1 Ep300 Plcg2 Prkcd Elk1 Rasa1 Cebpa Cd40 Tyk2 Nfkbia Crebbp Pik3ca Ikbkb Nfkb1 Ptpn6 Stat3 Cbl Cebpb Syk Ptpn11 H3c8 Mapk14 Stam Spi1 Il13 Cxcr4 Il13ra1 Snd1 Chuk Il4 Grk3 Mapk11 Il2rg H3c7 Irs2 Jak1 Mapk8 Ncoa3 Pik3cd Socs1 Bad IL-7%NETPATH%IL-7 IL-7 Akt1 Pik3r1 Stat3 Jak3 Mapk1 Il7r Mapk3 Shc1 Stam Cblb Stat5a Stat5b Foxo3 Foxo1 Map2k2 Il2rg Irs1 Irs2 Il7 Gsk3b Fyn Map2k1 Stat1 Gsk3a Bad NOTCH%NETPATH%NOTCH Notch Kat2b Akt1 Jak2 Pik3r1 Rela Mapk1 Mapk3 Ep300 Skp1 Lef1 Rbx1 Smad1 Hdac2 App Src Nfkb1 Hes1 Stat3 Tcf3 Cul1 Sin3a Fhl1 Mfng Ccn3 Gsk3b Skp2 Sap30 Hes6 Maml3 Notch4 Notch2 Psen2 Ncor1 Spen Ncstn Aph1b Ncor2 Dtx1 Dll3 Dll4 Maml1 Ring1 Maml2 Fbxw7 Furin Jag2 Cirsr Rbpj Yy1 Smad3 Lfng IL2%NETPATH%IL2 IL2 Il15 Creb1 Stat4 Il2ra Ybx1 Ets2 Akt1 Plcb1 Pik3r1 Tert Atf2 Rela Nr3c1 Ccne1 Itm2b Eif3b Il2 Mapk1 Prkcz Nmi Vil1 Ets1 Mknk1 Mapk3 Raf1 Shc1 Mtor Crkl Hsp90aa1 Stat5a Stat5b Cdk2 Bcl2 Elk1 Lyn Socs3 Pik3cg Stam2 Sgk1 Jun Lck Pik3ca Grb2 Sos1 Shb Nfkb1 Ptpn6 Jak3 Cbl Gab2 Vav1 Ptpn11 Il2rb Mapk14 Ptk2b Stam Foxo3 Map2k2 Il2rg Irs1 Irs2 Eif4ebp1 Crk Fyn Jak1 Pik3r2 Map2k1 Pik3r3 Eif4e Mapk8 Pik3cb Pik3cd TSLP%NETPATH%TSLP TSLP Relb Stat4 Akt1 Nfkb1 Rela Stat3 Mapk1 Stat6 Map2k1 Nfkb2 Mapk9 Mapk3 Eif4e Stat1 Mapk14 Mapk8 Nfkbia Stat5a Stat5b RANKL%NETPATH%RANKL RANKL Map3k7 Ptk2 Nfkb1 Rel Nfkb2 Traf3 Tnfsf11 Tab1 Atp6v1e1 Tab2 Sqstm1 Tnfrsf11b Mapk14 Trem2 Mapk8 Traf2 Traf6 Traf1 Traf5 Spi1 Mitf Chuk IL1%NETPATH%IL1 IL1 Rb1 Akt1 Pik3r1 Nfkb1 Atf2 Rela Map2k3 Dok1 Ppp6c Elp1 Mapk1 Mapk9 Mapk3 Tab1 Mapk14 Pla2g4a Peli1 Ube2v1 Ube2n Irak4 Irak3 Irak2 Irak1 Tollip Chuk Myd88 Il1a Fbxw5 Map3k2 Il1b Peli2 Il1r2 Il1r1 Il1rn Rel Pik3r2 Tab3 Tab2 Mapk8 Traf6 Nfkbia Map2k6 Jun Ikbkb Map3k14 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis Hacl2 Bcat1 Bcat2 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway Hk2 Hk1 Rpia Gpi Hkdc1 Taldo1 Pgd Tkt ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation Faah FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis Dhfr Mthfd1l Tyms Mtr Mthfd2 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism Hk2 Hk1 Gale Galt Aldob Aldoc Hkdc1 Aldoa Khk P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway Mef2d Elk1 Map3k7 Map2k6 Map3k4 Hspb1 Mapk12 Mapkapk3 Mapk13 Mapk14 Mapkapk2 Eef2k Eif4e Map2k4 Rps6ka4 Rps6ka5 Mef2c Mknk2 Mknk1 Tab2 Map3k10 Il1r1 Tab1 Mapk11 Traf6 Srf VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Pik3ca Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Hras Hspb1 Mapkapk3 Mapk14 Mapkapk2 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Cryaa Rac2 Kdr Akt1 Rac3 Rac1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Lpxn Arhgap8 Shc2 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Pik3cb Pik3ca Nos3 Il10 Ikbkb Il11 Mapk7 Spi1 Il15 Irs1 Cxcr1 Stat6 Cxcr2 Stat4 Il13 Il18 Il2ra Il2rb Irs2 Il15ra Mapk6 Sla2 Elk3 Elk4 Pdpk1 Akt3 Myc Akt2 Jak3 Foxo3 Il13ra1 Il13ra2 Fos Il20ra Il23a Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Il5ra Rps6ka2 Sos2 Sos1 Il6st Shc1 Il10rb Il3ra Il10ra Mtor Srf Il2 Il4 Elk1 Il6 Il5 Il7 Il9 Il21 Il12rb1 Mapk15 Il12rb2 Spic Mapkapk2 Il1a Stat5a Stat5b Il6ra Il4ra Stat3 Stat2 Mknk2 Stat1 Mknk1 Chuk Cdkn1a Cdkn1b Mapk1 Braf Mapk3 Akt1 Araf Nras Raf1 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis Flad1 Rfk HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis Ears2 Cox10 Alad Qars1 Rsad1 Hmbs Fech Eprs1 Cpox Urod Ppox NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway Cacna1g Cacna1c Epb41l2 Chrnb4 Clic6 Ppp1r1b Kcnk3 Chrnb3 Chrnb2 Gng2 Slc18a2 Adcy2 Drd2 Drd4 Ppp1ca Prkaca Kcnk9 Chrna3 Epb41 Chrna6 Chrna5 Chrna4 Gnb1 Flna Gnai1 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system Clock Csnk1d Csnk1e Bmal1 Per2 Per1 Per3 Cry1 Cry2 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis Sqle Fdps Mvk Pmvk Ggps1 Hmgcr Mvd Pdss1 Fdft1 Lss IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway Grin2a Shank1 Shank3 Grm3 Grm2 Slc1a1 Slc1a3 Slc1a2 Slc1a7 Grin1 Slc1a6 Slc17a8 Slc17a6 Vamp8 Vamp1 Gria4 Vamp3 Vamp2 Gria3 Snap29 Gria2 Gria1 Snap25 Grik5 Snap23 Stx19 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Stx11 Grin2b PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis Psat1 Pnpo CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccnd2 Ccnd3 Ccne1 Rpa3 Cinp P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 Pten Pik3c2g Rbl1 Pik3cg Cdk2 Pik3r5 Pik3cb Siah1a Pik3cd Mapk12 Atm Pik3ca Trp73 Mapk13 Mapk14 Pik3c2b Pik3c2a Hras Cdkn1a Mapk11 Pik3c3 Pdpk1 Akt1 Akt3 Akt2 Nras Ccne1 Ccng1 Ctnnb1 Trp63 Kras Pik3r1 Ppp2cb Pik3r2 Rb1 Pik3r3 Ppp2ca Trp53 Tpte THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis Thnsl1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation Abat HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway Prkcz Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Hrh1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Gng12 Itpr2 Itpr1 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Gnb1 Prkca METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway Itpr1 Prkar1a Prkar1b Grik5 Prkx Prkacb Grina Grm1 Grik1 Plcb4 Grm5 Homer1 Gna11 Grin2d Grin2c Grin2a Grin2b Prkaca Prkcb Gnaq Grin1 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Elk1 Map2k6 Mapk12 Mapk13 Myc Mapk14 Eef2k Mapk9 Jun Map2k4 Mapk8 Max Ddit3 Mef2c Txn Mknk2 Stat1 Map2k3 Mknk1 Bcl2 Mapk11 Pla2g4a 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Kcnk3 Gng2 Adcy2 Prkaca Kcnk9 Gnao1 Adcy7 Prkar2a Prkar2b Htr1d Gnb1 Htr1f Gnai2 Gnai1 Htr1b Htr1a Gng11 Gnai3 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway Prkcz Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Gnb1 Prkca Oxtr 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway Htr4 Gnal Gng12 Gng2 Gng10 Adcy2 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling Cacna1a Cacna1b Gabbr1 Gabbr2 Adcy4 Adcy1 Adcy8 Adcy5 Adcy6 Adcy9 Kcnj3 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Cacna1g Prkar1a Prkar1b Prkacb Adcy2 Prkaca Gnao1 Adcy7 Prkar2a Prkar2b Gnb1 Gnai1 Gng11 Gnai3 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway Ube2a Atg7 Sae1 Ube2l3 Ube2t Ube2v2 Uba6 Ube2k Uba7 Ube2n Ube2c Ube2b Uba1 Ube2d3 Uba2 Ube2e3 Uba3 Ube2d1 Ube2e2 Ube2e1 Ube2g2 Ube2g1 Ube2l6 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway App Erbb4 Apbb2 Nectin1 Apbb3 Trpc6 Afdn Trpc5 Cdh3 Trpc7 Wnt5a Kat5 Cdh1 Trpc1 Trpc4 Gsk3b Wnt5b Wnt9a Kat7 Wnt9b Fzd10 Ctnnb1 Wnt10a Bace2 Wnt10b Bace1 Acta1 Acta2 Actb Actr2 Notch4 Ern1 Notch1 Notch2 Notch3 Psen1 Wnt8b Wnt8a Psen2 Fstl1 Wnt16 Lrp1b Wnt11 Lef1 Ncstn Aph1b Lrp1 Lrp6 Lrp2 Lrp4 Lrp5 Wnt6 Rbpjl Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Actg1 Wnt4 Cd44 Wnt3 Tcf7l2 Fzd1 Fzd3 Actc1 Actbl2 Fzd2 Fzd5 Trim3 Jup Fzd4 Trim2 Fzd7 Fzd6 Fzd9 Fzd8 Rbpj Wnt2b 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation Aldh8a1 Aldh7a1 Aldh9a1 Il4i1 Aldh1l1 Aldh1l2 Aldh1b1 Maoa Aldh1a2 Aldh1a1 Maob Aldh3a2 Aldh4a1 Aldh2 Aldh3a1 Aldh1a3 Aldh16a1 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 Mdm2 Mdm4 Trp73 Cop1 Trp63 Trp53 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Hacl2 Bcat1 Bcat2 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization Acss2 Acss1 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis Dcakd Pank3 Pank2 Pank4 Pank1 Ppcs METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle Ireb2 Aco1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Pik3cg Pik3cb Pik3cd Pik3ca Map2k2 Map2k1 Hras Ikbkb Nfkbil1 Cd22 Vav3 Syk Vav1 Vav2 Map3k3 Map3k2 Blnk Btk Cd79a Cd79b Ptpn6 Ppp3ca Lyn Ptprc Ppp3cb Nfkbia Cd19 Grb2 Mapk10 Fos Sos2 Sos1 Mapk12 Mapk13 Mapk14 Chuk Mapk11 Mapk1 Itpr3 Mapk3 Itpr2 Itpr1 Rac2 Rac1 Araf Mapk9 Plcg2 Jun Mapk8 Nras Prkcb Prkcd Raf1 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation Akt1 Akt3 Trp73 Eif4ebp1 Tsc2 Akt2 Tsc1 Igbp1 Prkaa1 Prkab2 Prkaa2 Rps6kb2 Prkab1 Prkag1 Trp63 Ppp2cb Ppp2ca Trp53 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Plcb2 Liph Plcb1 Dagla Lpl Pla1a Plcb3 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Gmppa Pmm2 Gmds Gmppb Pmm1 Mpi MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing Snrpa Snrnp40 Zrsr2 Prpf3 Snrpb2 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation Arnt Hif1a Rorc Txn2 Crebbp Egln2 Egln3 Akt1 Akt3 Vhl Akt2 Txn Mtor THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism Thtpa Tpk1 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor Crebbp Gtf2a1l Polr2c Taf1c Taf9 Ep300 Creb3l3 Creb3l4 Polr2h Polr2e Creb3l1 Ttf2 Creb3l2 Polr2f Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Psmc3ip Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Tbp Brf2 Brf1 Prkar1a Tbpl2 Prkar1b Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Gtf2b Mterf2 Taf8 Taf7 Taf6 Taf4 Gtf2e1 Taf2 Gtf2e2 Prkar2a Prkar2b OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway Gng12 Gng2 Gng10 Adcy2 Oprd1 Pomc Gnao1 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Gngt2 Gnai2 Gnai1 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation Cyp2b10 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis Tgds Gfpt1 Gfpt2 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis Avp Oxt GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion Lgsn Glud1 Glul UNTITLED%PANTHER PATHWAY%P00019 untitled Edn1 Edn2 Gnal Edn3 Adcy10 Gucy1b1 Prkcz Prkg2 Adcy4 Prkg1 Adcy1 Gucy1a1 Adcy8 Gucy1a2 Adcy5 Nos3 Adcy6 Adcy9 Map2k2 Map2k1 Akt3 Akt2 Plcb4 Plcb3 Gna11 Gna14 Plcb2 Plcb1 Gnaq Mapk1 Pla2g4a Itpr3 Mapk3 Itpr2 Itpr1 Prkar1a Prkar1b Akt1 Prkacb Araf Prkcq Adcy2 Prkcg Prkch Prkci Prkaca Prkcb Adcy7 Prkcd Prkar2a Prkce Prkar2b Prkca Raf1 Ednrb Ednra Adcy3 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis Hdc TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis Dhfr Tyms Gch1 Fpgs 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway Prkcz Plcb4 Plcb3 Gna11 Htr2a Gng10 Htr2c Gna14 Htr2b Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Gnb1 Prkca Gng11 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway Col6a2 Ptk2b Col6a3 Lims2 Lamc3 Rapgef1 Lamc1 Lamc2 Map3k3 Map3k2 Mapk10 Map3k4 Mapk13 Map2k4 Braf Pik3c3 Mapk3 Rac2 Rac1 Araf Mapk9 Mapk8 Nras Map2k3 Raf1 Pik3r1 Pik3r2 Pik3r3 Pxn Pik3cg Pik3cb Pik3cd Pik3ca Pik3c2b Pik3c2a Ptk2 Map2k2 Col14a1 Map2k1 Map3k5 Hras Itgbl1 Crkl Arfgap1 Col10a1 Col1a2 Col5a2 Col5a3 Col5a1 Dmbt1 Col9a2 Col9a3 Col9a1 Lama5 Arpc1b Arpc1a Lama1 Lama2 Mapk6 Lama3 Lama4 Flnb Tln1 Vcl Vasp Col17a1 Col13a1 Fn1 Itga7 Itga8 Arl1 Itga5 Itga6 Itga9 Itga3 Itga4 Elmo2 Itga1 Itga2 Elmo1 Itga10 Sos2 Itga11 Sos1 Col4a3 Shc1 Col4a4 Arpc3 Col4a1 Cav1 Actb Arpc2 Col4a2 Col4a5 Col8a1 Col4a6 Col8a2 Parvb Arpc5 Parva Rap2b Col16a1 Rap2a Arf1 Rap2c Col12a1 Itgax Ilk Itgav Rnd2 Rhoc Rnd3 Rhoa Rhob Rnd1 Itgam Asap1 Itgae Arhgap10 Itgal Rap1a Rap1b Itgad Itgb8 Itgb6 Actg1 Itgb7 Itgb1 Itga2b Actn2 Itgb4 Rras Itgb5 Itgb2 Actn1 Actbl2 Actn4 Col20a1 Crk Arf6 Arpc5l Arhgap26 Col15a1 Col11a1 Col11a2 Src Ntn4 Dock1 Bcar1 Dnajc27 Lamb2 Lamb3 Flna Ptpn12 Fyn Csk Lamb1 Col2a1 Col27a1 Col6a1 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway Ehf Srgap1 Srgap3 Rab11b Arhgap6 Arhgap5 Arhgap4 Erf Erg Arhgap9 Shc3 Rasa1 Rasa4 Pdgfrb Vav3 Pdgfra Pdgfa Vav1 Pdgfrl Vav2 Pdgfb Map3k2 Grap Fli1 Rps6kc1 Fev Gabpa Nck2 Jak2 Jak1 Nck1 Arhgap15 Arhgap12 Gab1 Grb2 Gab2 Etv3 Mapk10 Spdef Elf1 Gsk3a Elf2 Elf3 Elf4 Elf5 Rps6kb2 Ophn1 Mycbp Usf2 Grap2 Elp1 Rerg Nin Pkn2 Ninl Arhgap42 Srf Elk1 Map3k4 Pik3r5 Mapkapk2 Rps6ka4 Rps6ka5 Mknk2 Mknk1 Mapk1 Braf Ets1 Itpr3 Pik3c3 Mapk3 Itpr2 Itpr1 Plcg1 Araf Plcg2 Jun Mapk8 Nras Arhgap1 Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Arhgap8 Shc2 Pik3cg Pik3cb Pik3cd Pik3ca Map2k2 Map2k1 Hras Ikbkb Mapk7 Stat6 Stat4 Mapk6 Elk4 Pdpk1 Myc Akt2 Jak3 Fos Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Shc1 Mapk15 Stat5a Stat5b Stat3 Stat2 Stat1 Chuk Arhgap10 Arhgap26 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway Slc44a3 Actr1a Myo3a Actr1b Acta1 Myo3b Acta2 Chrnb1 Actb Myo7a Slc18a3 Myo7b Slc6a8 Chrna10 Myh1 Myh2 Myh3 Myh15 Myh8 Myh9 Myh4 Myh6 Myh7 Myo1c Myo1b Myo1e Myo1d Myo5c Myo5b Myo1a Myh11 Myh14 Myh13 Myo1g Myo1f Plekhh3 Myh10 Myo18a Myo6 Myo18b Myo5a Myo9a Actg1 Slc5a7 Chrnd Chrne Chrng Chrna2 Chrnb4 Chrna1 Myo10 Actc1 Chrna9 Actbl2 Myo15a Chrnb3 Myo16 Chrnb2 Chrna3 Chrna6 Chrna5 Chrna4 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Jak2 Stat1 Jak1 Stat6 Jak3 Stat5a Stat4 Stat5b Stat3 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism Sugct SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis Psat1 Phgdh Psph AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin Pik3cg Pik3r5 Pik3cb Pik3cd Pik3ca Pik3c2b Pik3c2a Rac2 Vasp Rac1 Plcg1 Ntn1 Plcg2 Ntn3 Nfatc4 Rhou Nfatc3 Nfatc2 Ntn4 Ablim1 Dcc Ntng1 Unc5b Unc5d Unc5c Pik3r1 Pik3r2 Pik3r3 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Slc6a2 Slc6a3 Slc6a19 Slc6a18 Slc6a15 Slc6a17 Slc18a2 Slc6a20a Slc6a16 Slc18a1 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation Fmo3 Ugt1a2 Cyp2a5 Inmt Ugt1a5 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism Sugct S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mtr Mat2a Mat1a CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase Diaph2 Diaph1 Tubb2b Tubb2a Cfl1 Cfl2 Mylk2 Pfn1 Mylk3 Pfn3 Pfn2 Stmn1 Pak1 Pak6 Stmn4 Pak3 Pak2 Pak5 Pak4 Tubb5 Tubb6 Arpc1b Tubb3 Arpc1a Tubb1 Wasl Mylk Limk1 Arpc4 Rock2 Tubb4b Tubb4a Rock1 Myo3a Arpc3 Acta1 Myo3b Acta2 Actb Arpc2 Myh1 Myh2 Arpc5 Myh3 Myh8 Myh9 Myh4 Myh6 Myh7 Rhoc Myh11 Myh14 Myh13 Myh10 Actg1 Rac2 Actc1 Rac1 Actbl2 Rhou INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Elk1 Map2k2 Rps6ka4 Rps6ka5 Map2k1 Rasa1 Irs1 Mapk1 Irs2 Mapk3 Ins2 Insr Irs4 Igf2r Igf2 Igf1 Fos Insrr Rps6kb2 Igf1r Rps6ka3 Map2k3 Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Raf1 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Ifngr2 Jak2 Ifng Stat1 Jak1 Ifngr1 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis Tph2 Ddc Tph1 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides Upp1 Upp2 Uprt Nme3 Nme2 Nme4 Uck1 Uck2 Uckl1 Adat2 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway Cacna1a Cacna1b Adcy10 Grin2a Slc1a1 Slc1a3 Slc1a2 Slc1a7 Grin1 Slc1a6 Vamp8 Vamp1 Gria4 Vamp3 Vamp2 Gria3 Snap29 Gria2 Gria1 Snap25 Grik5 Snap23 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c Grin2b Cacna1e Grm4 Grm7 Grm8 Vti1a Stx1b Cacnb1 Stx1a Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Prkar1a Prkar1b Prkx Prkacb Grm1 Grm5 Prkaca Prkar2a Prkar2b Gnb1 Gnai2 Gnai1 Gnai3 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway Pik3cg Pik3cb Pik3cd Pik3ca Casp9 Map3k5 Ikbkb Nfkbia Akt3 Mapk10 Akt2 Igf2r Fos Trp53 Atf2 Eif2ak2 Birc3 Birc2 Tnf Madd Map2k4 Bcl2l11 Tnfrsf1b Tnfrsf1a Tradd Nfkb2 Chuk Nfkb1 Traf2 Bcl2l1 Xiap Endog Tnfsf10 Rela Mapk1 Relb Map3k1 Apaf1 Tnfrsf10b Lta Fadd Atf7 Mapk3 Ltb Atf6 Atf4 Atf3 Jdp2 Akt1 Aifm1 Gzmb Map2k7 Gzmf Map4k4 Map4k3 Mapk9 Prkcq Fasl Atf6b Jun Mapk8 Prkcg Cradd Prkch Bak1 Eif2s1 Casp8 Prkcb Casp7 Map2k3 Prkra Bcl2 Casp3 Prkcd Bik Ripk1 Prkce Map4k2 Prkca Diablo Bax Rel Fas Daxx Map3k14 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis Bcat1 Bcat2 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Ralb Exoc2 Pld1 Pld2 Pik3cg Ralgds Pik3cb Rgl1 Pik3cd Pik3ca Map2k2 Map2k1 Hras Pak1 Pak3 Pak2 Pdpk1 Grb2 Akt3 Mapk10 Gsk3a Rps6ka3 Gsk3b Rps6ka6 Rps6ka1 Rps6ka2 Sos2 Sos1 Shc1 Kras Srf Elk1 Map2k6 Map3k4 Mapk12 Mapkapk3 Atf2 Mapk13 Mapk14 Mapkapk2 Map2k4 Stat3 Rhoc Stat1 Rhoa Rhob Mapk11 Mapk1 Map3k1 Braf Ets1 Pik3c3 Mapk3 Rac2 Akt1 Rac3 Rac1 Map2k7 Araf Mapk9 Jun Mapk8 Nras Map2k3 Raf1 Tiam1 Rala ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Elk1 Grk3 Grk2 Agtr1a Arrb2 Arrb1 Plcb3 Egr1 Agt Gng10 Map2k2 Map2k1 Plcb2 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Mapk1 Gnb2 Gnb4 Gnb3 Gnb5 Itpr3 Mapk3 Itpr2 Itpr1 Gnb1 Prkca Raf1 Gng11 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation Gtf2a1l Polr2c Taf1c Taf9 Polr2h Polr2f Ttf1 Taf9b Taf11 Taf12 Gtf2h1 Gtf2f2 Gtf2h4 Gtf2f1 Gtf2h3 Brf2 Brf1 Tbpl1 Cfap20 Gtf2a1 Gtf2a2 Gtf2b Mterf2 Taf8 Taf7 Taf6 Taf4 Gtf2e1 Taf2 Gtf2e2 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway Pten Cdk2 Crebbp Mdm2 Atm Pik3ca Mdm4 Trp73 Gadd45g Sin3a Ep300 Chek2 Sumo3 Gadd45b Gadd45a Wrn Cdkn1a Hdac1 Traf2 Sfn Cdkn2a Mta2 Kat2b Gtse1 Pml Cdk1 Sirt1 Cdc25c Pdpk1 Akt1 Akt3 Akt2 Ccne1 Trp63 Trp53 Tpte THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway Cacna1a Cacna1b Prkcz Vamp8 Vamp1 Trh Vamp3 Trhr Vamp2 Stx3 Cga Snap29 Cacnb3 Cacnb4 Cacnb2 Snap25 Tshb Snap23 Cacna1e Cacnb1 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcd1 Plcb2 Plcd4 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Plcz1 Plce1 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Plcg1 Gng2 Prkcq Plcg2 Prkcg Prkch Prkci Prkcb Prkcd Prkce Prkca Gnb1 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b7 Hsd17b6 Hsd17b3 Soat2 Soat1 Hsd17b1 Hsd17b2 Lipa Cyp19a1 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb6 Ctnnb1 Pcdhgb7 Cdh5 Cdh4 Pcdh10 Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fer Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Cdhr1 Pcdha10 Pcdha11 Pcdha12 Pcdh1 Cdh19 Pcdh11x Cdh17 Cdh16 Cdh15 Cdh13 Cdh12 Cdh11 Cdh10 Ptpn1 Pcdh8 Pcdh7 Pcdh9 Pcdhgb1 Pcdhga5 Pcdhga6 Pcdhga7 Pcdhga8 Ctnnd2 Pcdhga1 Ctnnd1 Pcdhga2 Pcdhga3 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Acta1 Acta2 Actb Actr2 Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Wnt6 Wnt7b Wnt3a Wnt7a Wnt2 Tcf7l1 Wnt1 Actg1 Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd3 Actc1 Actbl2 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b UNTITLED%PANTHER PATHWAY%P06664 untitled Tgif1 Skil Rela PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation Aoc3 Aoc2 Aoc1 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle Pdha2 Mdh1 Suclg1 Ogdh Aco2 Sdhc Pdk2 Cs Fh Pdha1 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis Atp5f1b Atp5f1c ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation Odc1 Azin2 Azin1 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion Pccb Echdc1 Mmut LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis Lias PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism Dpysl2 Dpysl3 Cda Upb1 Dpysl5 Nt5e Aldh6a1 Dpys Dpyd Abat ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation Rpe BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway Gnal Gng12 Prkx Prkacb Adrb1 Gng2 Gng10 Adcy2 Prkaca Gng3 Gng4 Adcy7 Prkar2a Gng7 Prkar2b Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Irs2 Pten Pdpk1 Mdm2 Pik3ca Mdm4 Ins2 Insr Tsc2 Irs4 Tsc1 Gsk3a Igf2r Foxo3 Foxo1 Igf2 Igf1 Insrr Igf1r Gsk3b Irs1 Tpte HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Gnal Gng12 Prkx Prkacb Gng2 Hrh2 Gng10 Adcy2 Prkaca Gng3 Gng4 Adcy7 Prkar2a Gng7 Prkar2b Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gnal Gng12 Gng2 Gng10 Adrb3 Adcy2 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism Xdh Nt5e Ampd3 Gda METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis Mtr CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway Gnal Gng12 Gng2 Gna11 Gng10 Gna14 Crh Crhr2 Pomc Crhr1 Gng3 Gng4 Gng7 Gnaq Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway Apba3 Pkn1 Prkcz Psen1 Mapk12 Cacnb1 Mapk15 Mapk13 Psen2 Mapk14 Ncstn Aph1b Mapk7 Mapk11 Mapk1 Mapk3 Mapk6 Cacna1c App Cacnb2 Mapk10 Mapk9 Prkcq Mapk8 Prkcg Kat5 Prkch Prkci Prkcb Cacna1f Cacna1d Prkcd Pkn3 Pkn2 Klc1 Prkce Adam17 Prkca Mapk4 Bace2 Klc4 Klc3 Bace1 Klc2 Cacna1s Apba1 Apba2 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis Cbs AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo Cxcl12 Slit1 Rac2 Slit2 Slit3 Robo1 Cxcr4 Rac1 Srgap1 Abl1 Ntn1 Ntn3 Rhoc Ntn4 Dcc Ntng1 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis Nme1 Nme3 Dscaml1 Nme2 Dhodh Nme4 Cad Ctps2 Cps1 Ctps1 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway Pik3cg Prkcz Pik3cb Pik3cd Pik3ca Pik3c2b Pik3c2a Map2k2 Map2k1 Map3k5 Hras Shc3 Rasa1 Rasa4 Stat6 Map3k3 Map3k2 Grap Stat4 Erbb4 Gab1 Gab2 Akt3 Mapk10 Akt2 Sos2 Sos1 Shc1 Map2k6 Map3k4 Pik3r5 Mapk12 Mapk13 Mapk14 Stat5a Stat5b Map2k4 Stat3 Stat2 Erbb2 Stat1 Erbb3 Mras Rasal2 Gab3 Egfr Phldb2 Mapk11 Nf1 Prkd3 Rras2 Mapk1 Dab2ip Pebp4 Prkd1 Spry2 Braf Spry3 Prkd2 Spry1 Spry4 Pik3c3 Pebp1 Mapk3 Rac2 Rras Akt1 Rac1 Map2k7 Plcg1 Araf Mapk9 Prkcq Plcg2 Mapk8 Prkcg Prkch Prkci Nras Prkcb Map2k3 Prkcd Prkce Prkca Raf1 Shc2 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade Fgb Fga Mmp13 Mmp3 Fgg Plat Plg Mmp9 Mmp1a Plau Serpinf2 Serpine1 Plaur Serpinb2 PNAT%PANTHER PATHWAY%P05912 PNAT Slc6a3 Gng3 Gng4 Gng8 Vamp8 Vamp1 Gnb2 Gnb4 Vamp3 Gnb3 Vamp2 Stx3 Snap29 Epb41l2 Snap25 Clic6 Prkx Snap23 Ppp1r1b Prkacb Kcnk3 Slc18a2 Adcy2 Drd2 Epb41l3 Drd4 Drd1 Ppp1ca Drd5 Prkaca Ppp1cc Kcnk9 Gnaz Epb41 Adcy7 Prkar2a Prkar2b Gnb1 Flna Gnai2 Gnai1 Gng11 Gnai3 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway Crebbp Shh Smo Ptch1 Sufu Stk36 Fbxw11 Gli1 Btrc Gli3 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway Chrm2 Slc18a3 Chrm4 Slc6a8 Gnat2 Adcy10 Gnat1 Kcnj3 Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Slc5a7 Prkar1a Prkar1b Prkx Prkacb Prkaca Gnao1 Prkar2a Prkar2b Gnb1 Gnai2 Gnai1 Kcnj9 Gng11 Kcnj6 Gnai3 Kcnj5 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism Gnpda1 Amdhd2 Gnpda2 Gfpt1 Gfpt2 Npl TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway Bmp10 Bmp8a Skil Bmp15 Dcp1b Lefty2 Acvr1 Foxh1 Smurf2 Smurf1 Hras Jund Acvr1c Snip1 Lefty1 Tgfb2 Gdnf Tgfb3 Acvrl1 Cited1 Cited2 Acvr1b Amhr2 Fosl1 Mstn Gdf2 Bmpr1a Bmpr1b Gdf3 Gdf6 Bmp7 Gdf5 Bmp6 Gdf7 Mapk10 Bmp5 Bmp4 Bmpr2 Smad1 Bmp3 Smad2 Gdf9 Nodal Bmp2 Smad3 Bmp1 Smad4 Smad9 Acvr2a Tll2 Tll1 Gdf15 Inhba Acvr2b Inhbb Junb Inhbc Tgfbr1 Smad5 Smad6 Tgfbr2 Map3k7 Smad7 Gdf11 Crebbp Inhbe Gdf10 Mapk12 Atf2 Mapk13 Mapk14 Ep300 Tab1 Mapk11 Mapk1 Mapk3 Rras Mapk9 Jun Mapk8 Nras BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation F2r Klkb1 Gp5 Kng2 Proc Gp9 Gp1bb F13b Gp1ba Procr Vwf F10 F12 Proz F2 Tfpi F3 Serpina10 F7 Thbd F8 F9 Pros1 F2rl3 Fgb Fga Itga2b Fgg Plat Plg Plau Plaur PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway Gnat2 Pik3r5 Pik3cb Pik3ca Casp9 Nos3 Gna11 Gna14 Irs1 Gnaq Gngt2 Gnb2 Gnb4 Ptger1 Gnb3 Foxo4 Gnb5 Gngt1 Ywhaz Pdpk1 Akt1 Akt3 Insr Akt2 Foxo3 Foxo1 Rps6kb2 Nras Gsk3b Sos2 Gnb1 Sos1 Gnai2 Gnai1 Pik3r1 Pik3r2 Pik3r3 Gnai3 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Chrm2 Chrm4 Grm3 Grm2 Gsk3a Crebbp Gng10 Ep300 Creb3l3 Creb3l4 Creb3l1 Hrh1 Gng3 Creb3l2 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gngt1 Gng12 Adora2b Adora2a Adra2c Prkar1a Adra2b Prkar1b Htr6 Htr7 Prkacb Oprl1 Phka1 Grm1 Phka2 Grm5 Adrb2 Adra1b Adra1a Adra1d Sstr5 Sstr4 Sstr3 Oprd1 Sstr2 Sstr1 Oprm1 Htr5a Adcy7 Phkb Prkar2a Chrm1 Prkar2b Chrm3 Htr1d Chrm5 Htr1f Hrh4 Gnai2 Hrh3 Htr1b Adora1 Htr1a Adora3 Gnrhr Gnai3 Gys1 Adcy3 Htr4 Gys2 Gnal Clta Cltb Cltc Mtnr1a Creb1 Adcy4 Creb3 Adcy1 Phkg1 Adcy8 Phkg2 Adcy5 Mtnr1b Adcy6 Pygb Adcy9 Pygl Kcnj3 Htr2a Pygm Htr2c Gpr50 Htr2b Oprk1 Adrb1 Hrh2 Adrb3 Gsk3b Grm4 Grm7 Grm8 Rap1a Rap1b Gng2 Adcy2 Drd2 Drd4 Drd1 Drd5 Prkaca Gnb1 Gnai1 Kcnj9 Kcnj6 Kcnj5 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway Pik3cg Prkcz Pik3cb Pik3cd Pik3ca Pik3c2b Pik3c2a Map2k2 Map3k6 Map2k1 Map3k5 Frs2 Hras Frs3 Shc3 Fgfr3 Rasa1 Fgfr4 Rasa4 Fgfr1 Fgfr2 Map3k3 Map3k2 Grap Ptpn6 Akt3 Mapk10 Akt2 Sos2 Sos1 Shc1 Map2k6 Map3k4 Mapk12 Mapk13 Mapk14 Map2k4 Mapk11 Mapk1 Spry2 Spry3 Spry1 Spry4 Pik3c3 Pebp1 Mapk3 Rac2 Akt1 Rac1 Map2k7 Plcg1 Araf Mapk9 Prkcq Plcg2 Mapk8 Prkcg Prkch Prkci Nras Prkcb Map2k3 Prkcd Prkce Prkca Raf1 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis Asl Nags Otc Ass1 Cad Cps1 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction Gnat1 Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Cnga3 Pdc Cnga1 Gnb2 Grk1 Gnb4 Pde6g Rho Gnb5 Calml3 Gngt1 Rgs9 Gng12 Pde6a Pde6b Cngb3 Rcvrn Gng13 Gng2 Gnb1 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis Bcat1 Bcat2 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease Stx12 Elk1 Slc6a3 Gpr37 Ndufv2 Pld2 Psma7 Snca Mapk12 Mapk15 Mapk14 Mapk7 Sfn Mapk1 Mapk3 Ywhaz Psma4 Mapk10 Psma3 Psma6 Psma5 Ccne2 Mapk9 Psma2 Psma1 Mapk8 Cask Ywhah Ywhag Ywhae Th Ywhab Ccne1 Psmb10 Sncaip Psmb7 Prkn Psmb1 Septin5 Gpr37l1 Septin4 Psmb3 Stx7 Septin2 Septin1 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway Slc18a3 Pkn1 Prkcz Plcb4 Gna11 Gng10 Grin2a Gna14 Gng3 Gng4 Gng7 Gnaq Grin1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Slc5a7 Itpr3 Itpr2 Itpr1 Prkcq Grin2d Grin2c Prkcg Prkch Grin2b Prkci Prkcb Prkcd Pkn3 Pkn2 Chrm1 Prkce Chrm3 Gnb1 Prkca Gng11 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway Gng12 Pdyn Penk Gng2 Gng10 Adcy2 Oprd1 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Gngt2 Gnai2 Gnai1 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication Rfc5 Pold2 Pold1 H3c8 Rfc3 Rfc4 Pcna Rfc1 Rfc2 Pola1 Rpa2 Top2b Prim1 Top2a Top1 Dna2 H3-3b METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway Mcee Pcca Pccb Mmut DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis Ak3 Ak2 Nme5 Ak5 Adss2 Adss1 Ak8 Atic Nme7 Ppat Dscaml1 Nme6 Guk1 Gart Nme1 Nme3 Rrm1 Nme2 Rrm2 Nme4 Adsl Rrm2b Ak1 Gmps VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway Gc Rxra F13b Vdr Rara HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Chrm2 Clta Chrm4 Cacna1a Cltb Cacna1b Cltc Prkcz Oprk1 Grm3 Grm2 Gng13 Cacna1e Grm4 Grm7 Grm8 Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Rhoa Gng3 Gng4 Gng7 Gnaq Gng8 Gngt2 Rap1a Rap1b Gnb2 Gnb4 Gnb3 Gngt1 Itpr3 Gng12 Adora2b Itpr2 Adora2a Itpr1 Oprl1 Grm1 Grm5 Gng2 Prkcq Prkcg Drd2 Sstr5 Prkch Drd4 Sstr4 Prkci Drd1 Rap1gap Sstr3 Drd5 Oprd1 Sstr2 Prkcb Rasgrp3 Sstr1 Rasgrp4 Oprm1 Rasgrp1 Gnao1 Prkcd Rasgrp2 Arhgef1 Dnajc27 Prkce Garnl3 Chrm1 Prkca Bdkrb2 Chrm3 Gnb1 Bdkrb1 Chrm5 Gpr45 Adora1 Adora3 Gnrhr ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Axin1 Grb7 Pdgfc Pld1 Pdgfd Pld2 Tcf7 Efnb1 Efnb2 Jag2 Jag1 Pla2g4c Pla2g4d Birc5 Angpt1 Apc2 Epha3 Ephb1 Dll1 Ephb2 Ephb3 Rasa1 Dll3 Dll4 Pdgfrb Dlk1 Pdgfra Apc Pdgfa Tek Pdgfb Grap Nck2 Jak1 Nck1 Ctnnb1 Hspb1 F2r Mapkapk3 Mapk14 Mapkapk2 Map2k4 Prr5 Prkd3 Mapk1 Pla2g4a Prkd1 Braf Prkd2 Ets1 Pik3c3 Mapk3 Cryab Cryaa Kdr Akt1 Sh2d2a Plcg1 Araf Prkcq Plcg2 Jun Mapk8 Prkcg Prkch Prkci Nras Prkcb Sphk2 Arhgap1 Prkcd Sphk1 Prkce Prkca Raf1 Pik3r1 Pik3r2 Pik3r3 Lpxn Arhgap8 Shc2 Pxn Hif1a Vegfa Pik3cg Prkcz Pik3cb Pik3cd Pik3ca Casp9 Nos3 Pik3c2b Pik3c2a Ptk2 Map2k2 Tgfb1i1 Map2k1 Frs2 Hras Frs3 Crkl Fgfr1 Pak1 Pak3 Pak2 Akt3 Akt2 Wnt5a Fos Gsk3b Wnt5b Sos2 Wnt10a Sos1 Wnt10b Shc1 Notch4 Notch1 Notch2 Stat3 Rhoc Stat1 Rhoa Rhob Rbpjl Wnt7b Dvl1 Dvl2 Map3k1 Dvl3 Wnt7a Wnt2 Wnt1 Tcf7l2 Fzd1 Fzd3 Fzd2 Fzd5 Crk Src Rbpj Wnt2b Grb14 Fgf1 Dok1 Dok2 Dok3 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis Nme1 Tyms Dut Dtymk Nme3 Dscaml1 Rrm1 Nme2 Rrm2 Nme4 Rrm2b Adat2 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking Syt7 Syt6 Unc13c Rab3a Stxbp1 Snap25 Stx1b Unc13b Syt15 Stx1a Stx2 Unc13d Syt5 Syt3 Syt2 Vamp1 Syt1 Syt11 Syt12 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 Ptk2b Arrb2 Egr1 Ppp3ca Jak2 Lyn Nfkbia Grb2 Mapk10 Eif4ebp1 Nr2c2 Clu Ier3 Sp1 Sp3 Elavl1 Akt1s1 Yes1 Snai1 Tcf4 Ryr2 Ryr1 Hbegf Ryr3 Nos1 Ctnnb1 Hdac7 Akap1 Cckbr Pparg Gucy2e Arhgef28 Traf6 Cd38 Ptgs2 Srf Camk4 Mef2d Elk1 Map2k5 Ptpn11 Map2k6 Tpcn1 Tpcn2 Hspb1 Bad Cck Gast Map3k11 Mapk14 Eif4e Map2k4 Mef2c Mapk1 Pla2g4a Prkd1 Braf Prkd2 Mapk3 Itpr1 Akt1 Prkacb Rac1 Plcg1 Araf Mapk9 Prkcq Jun Mapk8 Prkch Prkcb Nfatc2 Bcl2 Prkcd Prkce Prkca Raf1 Pik3r1 Pxn Pik3cb Creb1 Prkg1 Adcy1 Ptk2 Map2k2 Map2k1 Mapk7 Pak1 Irs1 Odc1 Elk4 Pdpk1 Rock1 Foxo3 Foxo1 Fos Cdh1 Rps6ka3 Gsk3b Ywhab Rps6ka1 Sos1 Shc1 Atf2 Itgav Stat3 Rhoa Bcl2l1 Itgb1 Mmp3 Plau Crk Gng2 Slc18a2 Prkaca Src Casp3 Bcar1 Gnb1 Bax Map3k14 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Tpi1 Pklr Gpi Bpgm Hkdc1 Eno2 Pfkl Pkm EG433182 Hk2 Pgk1 Hk1 Pgam2 Pfkm Aldoa NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway Notch4 Notch1 Notch2 Notch3 Jag2 Jag1 Ncor2 Rbpj Dll3 Cirsr Dll4 Dlk1 Maml1 Rbpjl Numb GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis Csad Gad1 Aldh5a1 Abat Gad2 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway Casp9 Map2k4 Map3k5 Faf1 Parp4 Apaf1 Parp3 Parp2 Parp1 Fadd Cflar Lmnb1 Lmnb2 Gsn Casp6 Capg Lmna Scin Mapk10 Dffb Mapk9 Fasl Jun Mapk8 Casp8 Casp7 Casp3 Fas Daxx INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Col6a2 Ptk2b Col6a3 Jund Vav1 Grap Jak2 Kras Myo3a Junb Myo3b Myh1 Myh2 Myh3 Myh8 Myh9 Plcb4 Myh4 Plcb3 Myh6 Myh7 Gna11 Gng10 Gna14 Plcd1 Plcb2 Vwf Plcd4 Plcb1 Myh11 Gng3 Myh14 Gng4 Myh13 Gng7 Gnaq Gng8 Mapk1 Myh10 Plcz1 Plce1 Gnb3 Itpr3 Mapk3 Gng12 Itpr2 Itpr1 Rac2 Akt1 Prkx Prkacb Rac1 Cxcr3 Cxcr5 Plcg1 Cxcr6 Araf Cxcl10 Plcg2 C5ar1 Jun Fpr1 Ccr10 Nfatc4 Ccr1 Nras Xcr1 Nfatc3 Prkcb Ccrl2 Nfatc2 Ltb4r2 Gnao1 Rhog Fpr-s1 Ccr9 Prkce Ccr8 Ccr7 Raf1 Ccr6 Nfatc1 Gnai2 Ccr5 Ccr4 Ccr3 Ccr2 Gnai3 Cx3cr1 Ifnar1 Camk2d Ccl11 Pik3cg Ccl12 Prkcz Ccl7 Pik3cb Camk2a Pik3cd Ccl5 Pik3ca Ccl4 Ccl3 Adcy5 Ccl2 Adcy6 Pf4 Prex1 Cx3cl1 Nfat5 Ccl22 Col14a1 Mylk2 Ccl20 Mylk3 Ikbkb Pak1 Pak6 Cxcr1 Pak3 Pak2 Cxcr2 Pak5 Pak4 Arpc1b Arpc1a Mylk Arpc4 Pdpk1 Akt3 Rock1 Akt2 Cask Ifng Sos1 Shc1 Arpc3 Acta1 Acta2 Actb Arpc2 Il2 Arpc5 Cxcr4 Col12a1 Stat3 Rhoc Nfkb2 Chuk Rhoa Rela Relb Itgal Actg1 Itgb7 Itgb1 Rras Actc1 Actbl2 Col20a1 Gng2 Adcy2 Arpc5l Prkaca Gnai1 Col6a1 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway Pnp Hprt1 Gda HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease Cltb Tubb2b Tubb2a Grin2a Hip1 Bdnf Ift57 Dync1h1 Dnal4 Dctn1 Grin1 Rhoj Rhoq Dync1i2 Dync1i1 Ap2a2 Tubb5 Ap2a1 Tubb6 Arpc1b Hip1r Tubb3 Arpc1a Hap1 Tubb1 Kalrn Htt Gapdhs Dync1li2 Dync2h1 Dync1li1 Grik5 Tubb4b Dnai2 Tubb4a Dynll1 Dynll2 Grik2 Capn9 Grik1 Cyc1 Grik4 Capn5 Grik3 Sp1 Capn7 Grin2d Capn6 Grin2c Fos Capn1 Capn3 Grin2b Capn2 Dnah3 Dnah5 Dlg4 Dnah8 Cyfip2 Cyfip1 Capns1 Capn10 Trp63 Capns2 Capn11 Acta1 Acta2 Actb Trp53 Actr2 Crebbp Arpc5 Trp73 Map2k4 Ep300 Map3k10 Apaf1 Actg1 Tbp Rac2 Actc1 Rac1 Map2k7 Actbl2 Mapk9 Arpc5l Jun Taf4 Casp8 Rhog Casp3 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation Allc PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Pdha2 Pck1 Pklr Acly Cs Pcx Pkm Me1 Pdha1 Clybl T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Pik3cg Pik3cb Pik3cd Pik3ca Map2k2 Map2k1 Hras Ikbkb Vav3 Pak1 Vav1 Vav2 Pak3 Pak2 Nck2 Ppp3ca Nck1 Ptprc Ppp3cb Nfkbia Akt3 Akt2 Fos Grap2 Sos2 Sos1 Zap70 Cd28 Cd86 Cd80 Lck Lcp2 Cd3g Cd247 Cd3e Cd3d Ppp3cc Lat Chuk Mapk1 Map3k1 Braf Pik3c3 Mapk3 Itpr1 Akt1 Rac1 Plcg1 Araf Mapk9 Prkcq Jun Mapk8 Nras Raf1 Pik3r1 Pik3r2 Pik3r3 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway Elk1 Map3k7 Mapk14 Map3k8 Map2k2 Ikbke Tbk1 Map2k1 Ticam2 Irak4 Ikbkb Ticam1 Chuk Ecsit Nfkbie Tollip Irak1 Tab1 Myd88 Tank Irf3 Tlr9 Tlr8 Tlr7 Tlr6 Tirap Tlr4 Tlr3 Mapk3 Tlr2 Nfkbia Mapk9 Jun Mapk8 Map2k3 Traf6 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism Psat1 Pnpo Pdxk WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Ctnna3 Ctnna2 Csnk1d Ctnna1 Csnk1e Tle6 Bcl9 Csnk1g3 Hdac3 Csnk1g2 Hdac2 Tbl1xr1 Smarcb1 Hdac8 Csnk2b Smarca2 Sag Smarca1 Smarca4 Smarca5 Ctnnal1 Ppp3r2 Ppp3r1 Dact1 Smarcd1 Smarcd3 Smarcd2 Smarcc2 Smarcc1 Smad1 Smad4 Ctnnb1 Ppp2cb Ppp2ca Smad5 Siah1a Plcb4 Plcb3 Gna11 Gng10 Gna14 Plcb2 Plcb1 Gng3 Gng4 Gng7 Gnaq Gng8 Gnb2 Gnb4 Gnb3 Itpr3 Gng12 Itpr2 Itpr1 Nfatc4 Nfatc3 Nfatc2 Gng13 Cdh3 Wnt5a Cdh1 Wnt5b Wnt9a Wnt9b Fzd10 Wnt10a Wnt10b Wnt8b Wnt8a Fstl1 Wnt16 Wnt11 Lef1 Lrp6 Lrp5 Wnt6 Wnt7b Wnt3a Dvl1 Dvl2 Dvl3 Wnt7a Wnt2 Tcf7l1 Wnt1 Wnt4 Wnt3 Tcf7l2 Fzd1 Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Wnt2b Axin1 Arrb2 Arrb1 Hdac1 Ppp3ca Ppp3cb Pcdhb2 Pcdhb1 Pcdhb3 Cdh9 Cdh8 Pcdhb5 Cdh7 Cdh6 Pcdhgb6 Pcdhgb7 Cdh5 Cdh4 Pcdh10 Cdh2 Pcdhgb2 Pcdhgb4 Pcdh19 Pcdh18 Pcdh12 Pcdh15 Pcdha1 Crebbp Pcdhga11 Pcdhga10 Pcdhga12 Pcdha7 Pcdha6 Pcdha9 Pcdha8 Pcdha3 Pcdha2 Pcdha5 Pcdha4 Ep300 Pcdhgc3 Pcdhgc4 Pcdhgc5 Pcdhb16 Pcdhb17 Pcdhb18 Pcdhb19 Cdh24 Cdh23 Cdh22 Pcdhb13 Cdh20 Pcdhb15 Celsr3 Celsr1 Pcdhb10 Celsr2 Dchs1 Pcdh20 Fat2 Fat1 Fat3 Pcdhb20 Pcdhb21 Pcdhb22 Pcdhac1 Pcdhac2 Cdhr2 Prkcq Cdhr1 Pcdha10 Prkcg Pcdha11 Prkch Pcdha12 Prkci Pcdh1 Cdh19 Prkcb Pcdh11x Cdh17 Cdh16 Prkcd Cdh15 Cdh13 Prkce Cdh12 Prkca Cdh11 Cdh10 Nfatc1 Pcdh8 Pcdh7 Pcdh9 Pcdhgb1 Pcdhga5 Pcdhga6 Pcdhga7 Pcdhga8 Prkcz Pcdhga1 Pcdhga2 Pcdhga3 Gsk3b Ppp3cc Arr3 Smarce1 Srcap Tbl1x Nlk Kremen2 Kremen1 Siah2 Ino80 Gng2 Csnk2a2 Ep400 Hells Hltf Csnk1a1 Ppp2r5d Smarcal1 Ppp2r5c Ppp2r5b Ppp2r5a Ankrd6 Ppp2r5e Chd1l Gnb1 Arid1a Fbxw11 Pygo2 Btrc Pygo1 Tle4 Tle3 Tle2 Tle1 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Pnp Xdh Hprt1 Aprt Ada TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Lipc Lipe METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Cacna1e Cacna1a Gnat2 Adcy10 Cacna1b Stx1b Cacnb1 Stx1a Gng10 Grm3 Grm2 Gng3 Gng4 Gng7 Gng8 Gngt2 Vamp8 Vamp1 Gnb2 Gnb4 Vamp3 Gnb3 Vamp2 Gnb5 Snap29 Prkar1a Snap25 Prkar1b Prkx Snap23 Prkacb Prkaca Gnao1 Prkar2a Prkar2b Gnb1 Gnai2 Gnai1 Gng11 Gnai3 UNTITLED%PANTHER PATHWAY%P05916 untitled Gng12 Pdyn Gng2 Gng10 Adcy2 Oprk1 Gnao1 Gng3 Gng4 Adcy7 Gng7 Gnb1 Gng8 Avp Gngt2 Oxt Gnai2 Gnai1 Gnb2 Gnb4 Gnb3 Gnai3 Gnb5 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Dpysl2 Dpysl4 Plxnb1 Sema3a Sema4d Dpysl5 Cdk5 Rac2 Fes Crmp1 Dpys Frk Rac1 Rhoa Pak1 Arhgef1 Fyn Nrp1 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Cacna1g Cacna1a Cacna1b Cnr1 Grm1 Grm5 Plcb3 Plcb2 Plcb1 Gnao1 Gng3 Gng4 Gng7 Gnb1 Gng8 Gngt2 Gnai1 Gnb2 Gnb4 Gng11 Gnb3 Gnai3 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I Tbp Tbpl2 Tbpl1 Rrn3 Polr1b Taf1a Taf8 Taf1c Taf1b Polr1d Polr2k Cavin1 Ubtf Ttf1 Psmc3ip PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway Pnpo Pdxk SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides Tk1 Cda Adat2 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway Gnal Gng12 Prkx Prkacb Gng2 Adrb2 Gng10 Adcy2 Prkaca Gng3 Gng4 Adcy7 Prkar2a Gng7 Prkar2b Gnb1 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release Gnal Pdyn Creb1 Penk Gng10 Gng3 Gng4 Gng7 Gng8 Gngt2 Gnb2 Gnb4 Gnb3 Gnb5 Gng12 Prkx Prkacb Gng2 Adcy2 Prkaca Oprd1 Gnao1 Oprm1 Adcy7 Prkar2a Prkar2b Gnb1 Gnai2 Gnai1 Gnai3 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis Asns ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Itpr1 Adra2c Adra2b Plcb4 Plcb3 Gna11 Adra1b Adra1a Prkcg Plcb2 Plcb1 Adra2a Prkcd Prkce Prkca Plce1 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway Agt Ace ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway Kdr THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Pdha1 Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Mcee Echs1 Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway Hprt1 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway Nr3c1 Hsp90aa1 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId Nme2 Lalba Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway Ikbkb Cd40 Mapk14 Traf3 Traf6 Elp1 Ikbkg Nfkbia Map3k1 Dusp1 Cd40lg Nfkb1 Chuk Tnfaip3 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism Vac14 Sacm1l Inpp1 Pik3cb Pik3r4 Plcb4 Itpka Miox Ptpmt1 Inpp4a Pi4ka Ipmk Pikfyve Impa1 Mtor Isyna1 Becn1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency Prps1 Rpia Gpi Pfkl Taldo1 G6pdx Tkt Fbp1 Aldoa Rbks CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway Agt Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism Gys1 Gaa Agl Ugp2 Pygl Amy1 Pgm1 Ugdh Gpi Ugt3a2 Gusb Pgm2l1 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) Dlat Pck1 Dld Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb Echs1 Acat1 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 Cyp2c65 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria Gls2 Glud1 L2hgdh Pcx D2hgdh Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency Gpi Gusb Ugt8 Hk1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway Mapk8 Nfkbia Shc1 Map3k1 Ptpn7 Cd3g Cd247 Nfkb1 Elk1 Map2k7 Cd3d Mapk3 Calm1 Ubc Fyn Rac1 Ppp3ca Jun Ppp3cb Syk Fos Rela Nfat5 Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Prkcb Plcg1 Prkca PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway Nqo1 Nos3 Abcb1a Abcg2 Ralbp1 Por Abcc1 Abcc2 Slc22a16 Ndufs2 Ndufs7 Akr1a1 Xdh Cbr3 Cbr1 Akr1c18 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Agl Ugp2 Pygl Ugdh Gpi Ugt2b1 Amy2a5 Gusb Hk2 Gck Pgm2l1 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling Asns Amt Cps1 Dld Glul Gls2 Glud1 Hal Sds Gldc Aqp8 Asrgl1 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn Gstz1 Aldh3a1 Maoa Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Itpr1 Map2k1 Raf1 Cacna1c Cacna1f Cacna1d Hras Mapk1 Cacna1s Nfkbia Nfkb1 Prkcb Mapk3 Prkca Rela Plcb1 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor Itpr1 Prkca Gnaq Plcb1 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism Erbb2 Vac14 Synj1 Inpp4b Pik3c2a Pten Pik3r4 Pik3c3 Egfr Pik3r1 Fig4 Cdipt Ambra1 Pik3cd Pip5k1a Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Plcb1 Becn1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pck1 G6pc1 Gpi Fbp1 Tpi1 Aldoa Mdh2 Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Gpi Pfkl Taldo1 G6pdx Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgm1 Pgd Dera Pgls SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis Srm Odc1 Mat2b Mat2a ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism Agt Ace MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation Glo1 Ldhd Hagh FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria Pfkfb1 Gmds Pfkl Fbp1 Tpi1 Aldoa Gmppa Pmm1 Mpi Akr1b1 Uxs1 Sord Khk ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway Tyms Rrm2b Cmpk1 Dck Nme1 Dctd Nt5c Slc28a3 Slc29a1 Ctps1 Slc28a1 Rrm1 Rrm2 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Pdia2 Sdf2l1 Cyp2e1 Comt Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a5 Ugt1a1 Hspa5 Ephx1 Cyp3a16 Cyp2c50 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Nqo1 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis Nme2 Lalba Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism Nt5c2 Tyms Gda Rrm2b Dhodh Tymp Dctd Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) Acat1 Hsd17b10 Acadl Hadh Acads Acaa2 Echs1 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway Cyp3a16 Cyp2d22 Sult1a1 Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Qars1 Rps15a Rps18 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway Abcc2 Trp53 Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency Aldh1a1 Cyp3a16 Cyp2b10 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway Agt Ace DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency Nt5c2 Tyms Gda Rrm2b Dhodh Tymp Dctd Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis Dct Tyr PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism Farsb Il4i1 Gstz1 Got1 Hgd Pah Tat Yars1 Farsa Fah Hpd NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Taldo1 Tktl1 Pfkm Rbks Rpe Pgd Dera Aldob FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome EG433182 Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary Pfkfb1 Gmds Pfkl Fbp1 Tpi1 Aldoa Gmppa Pmm1 Mpi Akr1b1 Uxs1 Sord Khk AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway Cyp3a16 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway Agt Ace INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone Creb1 Gngt1 Fshr Prkacb Cga Gng12 Ppp1ca Gnb1 Adcy2 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency Ddc Pnmt Th GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism Acsm1 Glyat PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle Aqp1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism Impa1 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency Pck1 G6pc1 Gpi Fbp1 Tpi1 Aldoa Mdh2 Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway Abcc2 Cyp3a16 Cyp2d22 Cyp2b10 Slc22a1 Ugt1a9 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms Per1 Npr1 Cry1 Clock Csnk1e CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway Mapk8 Shc1 Map3k1 Elk1 Mapk3 Calm1 Rac1 Ppp3ca Jun Ppp3cb Syk Fos Nfat5 Cd79b Map2k1 Lyn Lck Orai1 Grb2 Blnk Raf1 Hras Prkcb Plcg1 Prkca GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins Tub Gngt1 Chrm1 Htr2c Gnaq Gnb1 Plcb1 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Eprs1 Rps14 Rpl4 Rps16 Rps15a Rps18 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Farsa Farsb Rps14 Rpl4 Rps16 Rps15a Rps18 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway Agt Ace GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease Bpgm G6pc1 Pgam1 Gpi Pgk1 Pfkm Aldoa Slc2a2 EG433182 Pgam2 Galm Pklr Hk2 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway Cyp3a16 Cyp2a5 Pdia2 Sdf2l1 Cyp2e1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Cyp1a2 Ugt1a6 Ugt1a9 Erp29 Ugt1a1 Hspa5 Sult1e1 Abcb1a Sult2a1 Abcg2 Abcc4 Abcc5 Ugt2b36 Abcc1 Gstt1 Cyp2d22 Sult1a1 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation Pccb Mmut Dbt Dld Bckdhb Sds Pcca Bckdha METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp3a16 Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Ugt1a9 Cbr1 Cyp2d22 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Aars1 Rpl4 Rps16 Rps15a Rps18 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Sars1 Agxt Psph Cth Aldh2 Shmt1 Sds Gatm Gldc FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway Abcc2 Trp53 Tubb1 Cdkn1a Abcc10 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria Gstz1 Aldh3a1 Maoa Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain Sdhd Sdhc Sdhb Sdha Ndufa1 ATP6 mt-Co1 Uqcrc1 Atp5f1d Atp5f1c Atp5pb Atp5f1b Atp5f1a Gpd2 Slc25a4 Slc37a4 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism Vkorc1 Nqo1 Ggcx LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway Scn10a Cyp3a16 Cyp1a2 Scn1b 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism Btd Hlcs Acacb Spcs1 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway Agt Ace OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism Gaa Ugp2 G6pc1 B4galt1 Pgm1 Gale Glb1 Lct Gla Akr1b1 Hk1 Galt FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway Cyp3a16 Aldh3a1 Cyp2e1 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism Itpk1 Nudt3 Inpp4b Minpp1 Itpka Inpp4a Ipmk Ippk Impa1 Bpnt1 Ip6k1 Isyna1 Inpp5j BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism Acat1 Hadh Acads Echs1 Acsm1 Hmgcl Oxct1 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome Cps1 Gad1 Glul Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Aldh4a1 Gmps Gfpt1 Qars1 Cad Ppat BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway Fdps Hmgcr Acat1 Idi1 Mvd Mvk Fdft1 Lss Sqle Pmvk BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I Gpi Pkm Pfkp Tpi1 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency Prps1 Rpia Gpi Pfkl Taldo1 G6pdx Tkt Fbp1 Aldoa Rbks PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis Pgs1 Gpam Gpd1 Crls1 Cdipt Cds1 Pla2g2d Ptdss1 Ptdss2 Gde1 Plpp1 Pisd Phospho1 Pld2 Pcyt1a Pla2g15 Lypla1 Ptpmt1 Chat Dgka Pemt Chka Agpat1 Gpd2 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway C9 Cfp C8a Cfb C3 Cfd C5 C6 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Slc6a4 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism Sptlc1 Acer2 Cerk Sptlc2 Degs2 Enpp1 Gba1 B4galt2 Ugt8 Sphk2 Ugcg Sdr16c5 Gla HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency Pck1 G6pc1 Gpi Fbp1 Tpi1 Aldoa Mdh2 Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides Cat Sod3 Sod2 Tyrp1 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway Cyp3a16 Abcb1a Abcg2 Pdia2 Sdf2l1 Abcc1 Abcc2 Hyou1 Pdia6 Pdia4 Bche Ppib Dnajb11 Ces2h Ces1d Top1 Ugt1a9 Erp29 Ugt1a1 Hspa5 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway Agt Ace WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect Ireb2 Gsr Glud1 Pkm Sdhd Sdhc Hk1 Sdhb Sdha Cs EG433182 Idh3g Mdh1 Mpc1 Pgd Fh Idh1 Idh3a Slc2a13 Cad Gapdhs Bpgm Aco1 Rpia Gpi H6pd Taldo1 Tktl1 Pfkm Bckdhb Pdhx Aldoc Gls Acly Ogdh Pgk2 Sucla2 Slc16a1 PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway Cyp3a16 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway Abcc2 Trp53 Tubb1 Cdkn1a Cyp3a16 Abcc10 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway Socs1 Map2k1 Irs1 Insr Grb2 Ptpn6 Ghr Raf1 Stat5a Stat5b Rps6ka1 Hras Mapk1 Slc2a4 Sos1 Ins2 Jak2 Shc1 Mapk3 Plcg1 Prkca KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct Slc14a2 Atp1a2 Atp1a1 Atp1a3 Aqp3 Aqp2 Atp6v1b1 Ca1 Slc4a1 Scnn1a Scnn1b Scnn1g Atp1b1 Atp1b3 Atp1b2 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle Gpd1 Gpd2 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome Dlat Pck1 Dld Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL Trp53 Grb2 Stat5a Pik3r1 Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism Vac14 Pik3r4 Pik3c3 Ptpmt1 Prex1 Pik3cd Inpp5f Plce1 Inppl1 Zfyve16 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Vars1 Rps14 Rpl4 Rps16 Rps15a Rps18 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) Mapk8 Map3k1 Jun Faf1 Arhgdib Map3k7 Pak1 Prkdc Ripk2 Fasl Parp1 Cflar Pak2 Lmnb1 Ptpn13 Lmnb2 Casp8 Rb1 Casp7 Casp3 Casp6 Sptan1 Lmna Map2k4 Fas Fadd Daxx Dffa Dffb ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway Abcc2 Tubb1 Slco1b2 Abcb1a Abcg2 Abcc1 Tuba1b PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I Agxt Gpt Mpc1 Pcx Aars2 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle Rpe Rpia Tpi1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway Adam17 Prkca Erbb4 Erbb3 Psen1 Nrg2 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway Agt Ace FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway Alox15 Ugt1a2 Cyp4f17 Cyp4f15 Slc22a8 Ptgds Cyp3a16 Cyp2j6 Cyp4f3 Cyp2c50 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Pdia2 Cyp2c65 Sdf2l1 Cyp2e1 Hyou1 Ephx2 Pdia6 Ptgs1 Pdia4 Alox12b Ppib Ptgs2 Slc22a6 Dnajb11 Ugt1a9 Erp29 Cbr1 Ugt1a1 Hspa5 Ugt2b1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule Slc7a5 Aqp1 Slc7a8 Slc4a4 Slc7a9 Slc9a1 Slc6a20a Ca1 Slc22a2 Slc22a6 Slc1a1 Slc3a1 Slc38a4 Slc3a2 Slc7a6 Slc7a7 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway Map2k1 Grb2 Ptpn6 Epo Raf1 Epor Stat5a Hras Sos1 Jak2 Mapk8 Shc1 Elk1 Mapk3 Plcg1 Jun Fos CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway Cyp3a16 Oprm1 Cyp2d22 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway Ace LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway Rpe Prps1 Pgm1 Rpia Dera Gpi Pfkl Pgls G6pdx Tkt Fbp1 Aldob HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development Srf Nkx2-5 Gata4 Hopx GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency Dpyd Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell Rapgef4 Glp1r Camkk1 Itpr3 Abcc8 Cacna2d2 Cacna1a Slc2a2 Chrm3 Cacnb1 Prkca Gng2 Adcy10 Gnaq Vamp2 Gnb1 Plcb1 Rab3a LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin Creb1 Htr6 Gngt1 Prkacb Ppp1ca Gnb1 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway Cyp3a13 Cyp3a16 Oprm1 Grin2a Cyp2d22 Cyp2c50 Cyp2b10 Grin1 Cyp2c65 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism Ahcy Cbs Cth Mettl6 Mars1 Scly Ggt1 Sephs2 Mat2b Slc39a8 Papss1 Mat2a GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 Gngt1 Prkacb Gnb1 Adcy2 Ptgdr DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway Ace STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism Gys1 Ganab Hkdc1 Pgm2 Gpi Gbe1 Hk1 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria Farsb Il4i1 Gstz1 Got1 Hgd Pah Tat Yars1 Farsa Fah Hpd FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling Itpr1 Akt1 Adcy1 Rock1 Lpar4 Srf Gng2 Gnb1 Plcb1 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism Thtpa Tpk1 Ntpcr Slc19a2 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Hsd17b1 Ugt2b38 Cyp19a1 ARGININEMIA%PATHWHIZ%PW000183 Argininemia Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease Asns Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages Itpr1 Map2k1 Nfkb1 Prkcb Raf1 Mapk3 Prkca Hras Mapk1 Nfkbia Rela Plcb1 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway Gstz1 Aldh3a1 Maoa Ddc Pnmt Aoc1 Got1 Acss1 Hgd Haao Mif Dbh Tyr Fah Cyp2e1 Comt Cat Dct Aldh1b1 Aldh2 Acss2 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway Map2k1 Irs1 Grb2 Ptpn6 Ghr Raf1 Stat5a Stat5b Rps6ka1 Hras Mapk1 Slc2a4 Ins2 Jak2 Shc1 Mapk3 Gh Plcg1 Prkca 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism Agxt Gpt Mpc1 Pcx Aars2 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Mcee Echs1 Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III Ugp2 Pgm1 Ugdh Galk1 Gale Gck Galt Uxs1 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway Akt1 Plcg1 Pik3r6 Prkca Pik3cg Vav1 Plcb1 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging Nmnat3 Nmnat2 Nadk Nqo1 Npr1 Nmnat1 Clock Nampt Ppargc1a Sirt1 Rora CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin Htr7 Creb1 Gngt1 Prkacb Ppp1ca Gnb1 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway Nr3c1 Hsp90aa1 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway Ugt1a2 Slc22a8 Cyp3a16 Cyp2c50 Pdia2 Cyp2c65 Sdf2l1 Hyou1 Ptgs1 Pdia6 Pdia4 Ptgs2 Ppib Slc22a6 Dnajb11 Ugt1a9 Ugt2b1 Erp29 Ugt1a1 Hspa5 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis EG433182 Pgam2 Galm Pgam1 Gpi Pkm Pfkp Hk1 Tpi1 Slc2a1 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Cyp1a2 Slc6a2 Slc6a4 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Slc9a1 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Prkar1b Kcnj4 Chrm2 Prkar2a Kcnk1 Prkar2b Kcnq1 Atp1b4 Slc8a1 Mcu Adrb1 Cacnb1 Prkacb Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cyp1a2 Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Atp1b2 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway Chrna4 Chrna3 Cyp2b10 Cyp2a5 Ugt1a9 Chrnb2 Fmo3 Ugt1a5 Aox1 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis Tmlhe Setd7 Shmt1 Bbox1 Aldh9a1 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb Echs1 Acat1 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis Trp53 Grb2 Stat5a Pik3r1 Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism Cps1 Gad1 Glul Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Aldh4a1 Gmps Gfpt1 Qars1 Cad Ppat XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway Ampd1 Slc29a2 Slc28a2 Paics Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Abcc4 Nudt2 Abcc5 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Aox1 Atic Adk Nme6 Tpmt Ppat GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb Echs1 Acat1 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway Nme2 Ak2 Ak1 Nme1 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway Ampd1 Slc29a2 Slc28a2 Paics Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Abcc4 Nudt2 Abcc5 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Aox1 Atic Adk Nme6 Tpmt Ppat CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism Mpst Ctns Cdo1 Cth Cars1 Gclc Gclm Got1 Ldha MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway Egfr Rasa1 Srf Stat6 Jak1 Egf Sos1 Stat3 Stat2 Mapk8 Stat1 Shc1 Map3k1 Elk1 Mapk3 Jun Fos Map2k1 Grb2 Raf1 Hras Map2k4 Prkcb Plcg1 Prkca FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation Pfkfb1 Gmds Pfkl Fbp1 Tpi1 Aldoa Gmppa Pmm1 Mpi Akr1b1 Uxs1 Sord Khk BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) Cbs Cth VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism Pdxp Pnpo Aox1 Pdxk Alpl NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism Ugp2 Galk2 Pgm1 Ugdh Gale Hk1 Galt Uxs1 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway Agt Ace PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Mars1 Rps14 Rpl4 Rps16 Rps15a Rps18 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway Tyms Ces1d Tymp Cda Slc28a1 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism Flad1 Rfk Acp1 Enpp1 Tyr ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway Ugt1a2 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Pdia2 Slc6a3 Sdf2l1 Adra1a Hyou1 Scn10a Pdia6 Pcsk2 Pdia4 Chrna4 Ppib Oprm1 Dnajb11 Htr1a Ugt1a9 Erp29 Ugt1a1 Hspa5 Atp1a2 Atp1a1 Atp1a3 Cacna1a Ugt2b36 Ugt2b1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids Acat1 Hsd17b10 Acadl Hadh Acads Acaa2 Echs1 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb Echs1 Acat1 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis Plpp1 Gnpat Cept1 Agps Agpat1 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency Sult1a1 Chst11 Sult2b1 Suox Papss2 Bpnt1 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb Echs1 Acat1 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway Agt Ace CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway Hrh2 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway Ptgs1 Cyp3a16 Ptgs2 Cyp2d22 Ugt1a9 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway Nme2 Ak2 Ak1 Nme1 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation Atp1a2 Atp1a1 Atp1b1 Atp1b3 Atp1a3 Atp1b2 Gck Treh Slc2a2 Slc5a1 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism Dlat Pck1 Dld Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway Cyp3a13 Maoa Cyp2d22 Cyp2c50 Aox1 Slc6a4 Maob ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle Slc25a22 Gpt Slc1a4 Glud1 Slc2a4 Slc38a4 Slc2a2 Gpt2 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway Tyms Rrm2b Cmpk1 Dck Nme1 Dctd Nt5c Slc28a3 Slc29a1 Ctps1 Slc28a1 Rrm1 Rrm2 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect Gls2 Glud1 Pkm Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 EG433182 Pgam2 Idh3g Pdha1 Suclg1 Mdh1 Pklr Mpc1 Pgd Suclg2 Fh Pgls Idh1 Idh3a Ldha Dlst Pdhb Idh3b Aldob Aco2 Dlat Aco1 Dld Rpia Gpi Pfkl Taldo1 Pgk1 G6pdx Tkt Slc2a2 Slc1a5 Hk2 Slc16a1 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway Ace TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL Trp53 Grb2 Stat5a Pik3r1 Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect Gls2 Glud1 Pkm Pcx Pfkp Sdhb Sdha Cs Dhtkd1 EG433182 Suclg1 Mdh1 Mpc1 Pgd Suclg2 Fh Idh1 Idh3a Pdhb Idh3b Aco2 Dlat Tktl2 Aco1 Pdha2 Dld Slc16a4 Slc1a2 Rpia Gpi Taldo1 Pgk1 G6pdx Hk2 Slc2a1 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) Sc5d Cyp51a1 Hsd17b7 Nsdhl Msmo1 Dhcr7 Lbr Dhcr24 Ebp ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway Tyk2 Mapk1 Jak1 Stat3 Mtor IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway Bche Oprm1 Ces2h Ces1d INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism Vac14 Synj1 Plcb4 Pik3c3 Ptpmt1 Cct3 Pik3ca Ipmk Bpnt2 Impa1 Isyna1 Becn1 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway Map2k1 Raf1 Hras Pik3ca Vav3 Rala Casp9 Ralbp1 Pld1 Rhoa Bad Ralgds Bcl2l1 Smad3 Elk1 Smad4 Chuk Apaf1 Akt1 Foxo4 Mapk3 Rac1 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis Cyp11a1 Agtr1a Hsd3b6 Gng2 Cyp21a1 Gnaq Gnb1 Cyp11b2 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency Rpia Gpi Pfkl Taldo1 G6pdx Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgm1 Pgd Dera Pgls CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis Ddc Pnmt Th ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway Egfr Abcb1a Abcg2 NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria Mpst Ctns Cdo1 Cth Cars1 Gclc Gclm Got1 Ldha ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway Itga2b Itgb3 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway Ace LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling Itpr1 Akt1 Adcy1 Rock1 Lpar5 Srf Gng2 Gnb1 Plcb1 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway Aldh1a1 Cyp3a16 Aldh3a1 Cyp2b10 Cyp2a5 Cyp2c65 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) Glp1r Slc10a2 Gpbar1 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling Map2k1 Irs1 Insr Grb2 Raf1 Hras Mapk1 Slc2a4 Sos1 Ins2 Mapk8 Shc1 Akt1 Pik3r6 Pik3cg Irs2 Map2k2 Pdpk1 Foxo1 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency Dlat Pck1 Dld Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Lars1 Rps18 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism Synj1 Nudt3 Ipmk Bpnt2 Impa1 Isyna1 Ip6k1 Ppip5k1 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid Mdh1 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism Vac14 Plcd4 Synj1 Pik3r4 Pik3c3 Impa1 Becn1 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Sars1 Agxt Psph Cth Aldh2 Shmt1 Sds Gatm Gldc GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway Itga2b Itgb3 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway P2ry12 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System Prkacb Drd1 Adcy2 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway Cyp3a13 Cyp3a16 Cyp2c50 Cyp2b10 Ephx1 Cyp2c65 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway Pcna Cdkn1a Ccne1 Ccnd1 Gadd45b Cdk4 Cdk2 Bcl2 Cdk1 E2f1 Bax Rb1 Apaf1 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency Agl Ugp2 Pygl Ugdh Gpi Ugt2b1 Amy2a5 Gusb Hk2 Gck Pgm2l1 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway C9 C8a Cfb C1qb C1qa C1rb Serping1 Masp2 C2 C4a C1s2 C1qc Mbl2 C3 Cfd C5 C6 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway Psma4 Psmc6 Ubc Psmc5 Psma3 Psma6 Psma5 Psmc2 Psmc1 Psmc4 Psma2 Psmc3 Psma1 Ubd Psmd13 Ube2e1 Psmb5 Psmb4 Psmb7 Psmb6 Psmb1 Psmb3 Psmd4 Psmb2 Stub1 Uba1 Psma7 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway Itpr1 Mapk8 Map3k1 Elk1 Map2k7 Calm1 Jun Map2k1 Grb2 Raf1 Hras Mapk1 Pld1 Gna11 Src Fshb Lhb Gnrh1 Prkcb Gnrhr Hbegf Camk2a Cga Adcy5 Prkca Cdc42 Egr1 Mmp14 Erbb4 Lrrc7 Mmp2 Actn4 Plcb1 Atf4 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism Nat1 Cyp3a16 Cyp1a2 Xdh Cyp2a5 Cyp2c65 Cyp2e1 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway Cyp3a16 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Atp1b2 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary Pfkfb1 Gmppb Gmds Phpt1 Fcsk Fpgt Gfus Pfkl Hk1 Fbp1 Tpi1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis EG433182 Gpi Pkm Hk2 Pfkp Slc2a1 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway Cd79a Nfatc4 Nfatc1 Nfatc3 Nfatc2 Sos1 Ppp3cc Btk Mapk8 Shc1 Map3k1 Elk1 Mapk3 Rac1 Ppp3ca Vav1 Jun Ppp3cb Syk Fos Cd79b Map2k1 Lyn Orai1 Grb2 Blnk Raf1 Hras Prkcb Plcg1 Prkca LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling Itpr1 Akt1 Adcy1 Rock1 Srf Gng2 Lpar1 Gnb1 Plcb1 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism Acat1 Hmgcl Bdh1 Oxct1 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism Asns Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL Trp53 Grb2 Stat5a Pik3r1 Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway Mpo Cyp3a16 Top2a PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis Pcyt2 Pisd Pcyt1a Cept1 Pemt Chka HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism Itpk1 Vac14 Synj1 Sacm1l Inpp1 Minpp1 Pik3r4 Cct3 Pik3ca Ambra1 Plcd1 Itpka Miox Ptpmt1 Pi4ka Impa1 Isyna1 Becn1 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis Casp3 Gzmb Hmgb2 Endog Dffa Cad Casp7 Top2a GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis Pck1 G6pc1 Gpi Fbp1 Tpi1 Aldoa Mdh2 Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway Itga2b Itgb3 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA Prkar1b Prkar2a Prkar2b Gngt1 Prkacb Prkar1a Adcy10 Prkaca Gnb1 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Kars1 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway Tktl2 Rpe Prps1 Pgm1 Rpia Dera Gpi Taldo1 G6pdx Pfkp Fbp1 Rbks TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I Gstz1 Aldh3a1 Maoa Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome Gpi Gusb Ugt8 Hk1 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway C9 C2 C4a C8a C1s2 C1qc C1qb C3 C1qa C1rb C5 C6 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis EG433182 Pgam2 Bpgm Galm G6pc1 Pgam1 Gpi Pkm Pfkm Tpi1 Slc2a2 Aldob FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism Pfkfb2 Fbp1 Hk1 Aldoa Sord CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism Gpi Gusb Ugt8 Hk1 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism Nmnat2 Nadk Nt5c2 Enpp1 Pnp Nudt12 Nnmt Qprt Nmrk1 Nampt Bst1 Nnt Aox1 Nadsyn1 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism Gstz1 Aldh3a1 Maoa Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway Ace ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism Gpi Pfkfb2 Hk1 Sord ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway Cyp3a16 Abcb1a Pdia2 Sdf2l1 Top2a Mpo Hyou1 Ptgs1 Pdia6 Pdia4 Ptgs2 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Abcc3 Top2b IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL Trp53 Grb2 Stat5a Pik3r1 Slc22a1 Sos1 Abcb1a Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease Hk1 Chit1 Gnpda1 Amdhd2 Hexa Uap1 Npl Nanp Nagk Gnpnat1 Gfpt1 Pgm3 Renbp Cmas Nans Slc17a5 Gne DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism Afmid Aanat Tph1 Kmo Aadat Inmt Wars2 Ddc Wars1 Tdo2 Kynu Cyp1a1 Acmsd Haao Ido1 Cat Aldh2 LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation Ikbkb Traf6 Pfkp Sdhd Slc25a1 Ikbkg Sdhc Sdhb Myd88 Nfkbia Sdha Ly96 Cs Cd14 Tirap Nfkb1 Tlr4 Chuk Acaca Mdh1 Acly Me1 Rela HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Sars1 Agxt Psph Cth Aldh2 Shmt1 Sds Gatm Gldc CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis Avpr2 Gngt1 Fshr Prkacb Gng12 Gnb1 Adcy2 COAGULATION%SMPDB%SMP0000586 Coagulation Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation Cat Aldh1b1 Aldh2 Acss1 Acss2 Cyp2e1 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism Agl Ugp2 Pygl Ugdh Gpi Ugt2b1 Amy2a5 Gusb Hk2 Gck Pgm2l1 GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Gars1 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia Gaa Ugp2 G6pc1 B4galt1 Pgm1 Gale Glb1 Lct Gla Akr1b1 Hk1 Galt BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) Sc5d Cyp51a1 Hsd17b7 Nsdhl Msmo1 Dhcr7 Lbr Dhcr24 Ebp TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) Farsb Il4i1 Gstz1 Got1 Hgd Pah Tat Yars1 Farsa Fah Hpd VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway Abcc2 Tubb1 Slco1b2 Abcb1a Abcg2 Abcc1 Tuba1b SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) Trp53 Nmnat3 Nmnat2 Nadk Aifm2 Cd38 Nqo1 Nmnat1 Nampt Sirt1 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer Gls2 Glud1 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh2 Idh3a Ldha Dlst Me1 Pdhb Slc7a7 Idh3b Aco2 Dlat Dld Got2 Mycbp Slc38a5 Slc1a5 Slc1a4 Acly Slc16a1 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis Rpe Rpia Tpi1 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle Atp1a2 Clcnkb Atp1a1 Atp1b1 Atp1b3 Atp1a3 Atp1b2 Slc12a6 Slc12a1 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway Atp4a Atp4b DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Eprs1 Rps14 Rpl4 Rps16 Rps15a Rps18 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency Ddc Pnmt Th SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency Agl Ugp2 Pygl Ugdh Gpi Ugt2b1 Amy2a5 Gusb Hk2 Gck Pgm2l1 ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway Map2k1 Raf1 Hras Mapk1 Nfkbia Nfkb1 Gngt1 Mapk3 Plcg1 Cxcl12 Ptk2b Pxn Crk Pik3c2g Ptk2 Bcar1 Cxcr4 Gnaq Gnai1 Gnb1 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb Echs1 Acat1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome Agl Ugp2 Pygl Ugdh Gpi Ugt2b1 Amy2a5 Gusb Hk2 Gck Pgm2l1 SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway Ace FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway Agt Agtr1a Ace DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway Grin2a Cyp2c50 Maoa Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Maob Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Aox1 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) Cps1 Gad1 Glul Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Aldh4a1 Gmps Gfpt1 Qars1 Cad Ppat WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary Fbp2 Aldoc Pfkm Hk1 Tpi1 Aldob LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Cyp3a16 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Cyp1a2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia Agxt Gpt Mpc1 Pcx Aars2 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling Tank Tnf Map2k6 Map4k2 Map2k3 Tradd Ikbkb Cradd Traf2 Mapk14 Ikbkg Mapk8 Nfkbia Map3k1 Nfkb1 Chuk Map2k7 Map2k4 Jun Casp2 Ripk1 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation Phyh Abcd2 Aldh3a2 Slc27a2 Hacl1 Abcd1 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway Akt1 Plcg1 Pik3r6 Prkca Plcb1 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck CYSTINURIA%PATHWHIZ%PW000700 Cystinuria Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Hadha Hadhb Acadl Hadh Cpt2 Acaa2 Cpt1a Slc25a20 Acsl1 Echs1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism Inpp1 Itpka Inpp4a Nudt4 Ip6k2 Ipmk Impa1 Isyna1 Ppip5k1 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Pank3 Fbp1 Tpi1 Slc2a2 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Aldob PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway Grin2a Kcnd2 Cyp2b10 Cyp2a5 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Ugt1a9 Ugt1a5 Atp1a2 Atp1a1 Atp1a3 Cacna1a Chrna3 Cacnb1 Atp1b1 Fmo3 Atp1b3 Atp1b2 Aox1 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism Aldh3a1 Maoa Aoc1 Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Carns1 Hars2 Aldh2 Ftcd Hal Cndp1 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Iars1 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle Slc25a11 Got2 Slc25a12 Mdh2 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) Nt5c2 Tyms Gda Rrm2b Dhodh Tymp Dctd Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway Aldh7a1 Gnmt Mat2a Chdh Dmgdh Shmt2 Sardh Bhmt Slc44a1 Slc44a2 Mtr Shmt1 Mat2b PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway C9 Masp2 C2 C4a C8a Mbl2 C3 C5 C6 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis Acaca Fasn CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway Tyms Ces1d Tymp Cda Slc28a1 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rars1 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism Dpyd Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway Mpo Cyp3a16 Top2a TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria Slc25a11 Pdha1 Mdh1 Mpc1 Pcx Acly Me1 Pdhb CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway P2ry12 Cyp3a16 Cyp2c50 Cyp1a2 Cyp2b10 Pon1 Abcb1a CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency Cps1 Gad1 Glul Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Aldh4a1 Gmps Gfpt1 Qars1 Cad Ppat ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Adra1a Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) Hadha Hadhb Hsd17b10 Acaa2 Echs1 Mecr Ppt1 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency Nt5c2 Tyms Gda Rrm2b Dhodh Tymp Dctd Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells Tnf Map2k6 Map2k3 Mapk14 Sos1 Btk Mapk8 Gab2 Map2k7 Fyn Rac1 Syk Il13 Pla2g4a Fcer1a Il4 Map2k1 Il5 Lyn Kras Grb2 Pdk1 Ms4a2 Raf1 Nras Pik3r1 Fcer1g Lat Csf2 Hras Mapk1 Pik3ca Lcp2 Vav3 Akt1 Map2k4 Plcg1 Prkca Map2k2 Inpp5d DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway Rpia Fbp2 Gpi H6pd Prpsap1 Taldo1 Tktl1 Pfkm Rbks Rpe Pgd Dera Aldob THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria Gls2 Glud1 L2hgdh Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway Tktl2 Rpia Gpi Taldo1 Prps2 G6pdx Pfkp Fbp1 Rbks Rpe Pgm1 Dera Pgls SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation Nfkb1 Creb1 Mapk3 Ikbkb Prkca Mapk1 Nos3 Ikbkg Plcb1 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway Egfr THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form Btd Hlcs Acacb Spcs1 LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway Atp4a Atp4b NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia Asns Adsl Gad1 Asl Abat Nars1 Il4i1 Adss1 Ddo Aspa Dars1 Ass1 Cad Asrgl1 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Sars1 Agxt Psph Cth Aldh2 Shmt1 Sds Gatm Gldc ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism Gad1 Cdo1 Csad Ggt6 Ado SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway Pde4d HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway Egfr THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway Ampd1 Slc29a2 Slc28a2 Paics Nt5c2 Ada Slc28a3 Slc29a1 Prps1l1 Rac1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Abcc4 Nudt2 Abcc5 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Aox1 Atic Adk Nme6 Tpmt Ppat PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency Prps1 Rpia Gpi Pfkl Taldo1 G6pdx Tkt Fbp1 Aldoa Rbks QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway P2ry12 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation Btg1 Trp53 Prmt1 Ngf Fgf1 Ccnd1 Chaf1a Rb1 Hoxb9 Btg2 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway Abcc8 Cacnb1 Cacna2d2 Ins2 Cacna1a Slc2a2 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium Gucy1b1 Nos3 Trpv4 Prkg2 Prkg1 Gucy1a1 Trpc7 Kcnq5 Trpc4 Kcnq4 Gucy1a2 Trpc3 Adcy10 Kcnq3 Kcnq2 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Cyp1a2 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway Chpt1 Cmpk1 Dck Slc22a1 Nme1 Nt5c Pgk1 Abcb1a Abcg2 Abcc4 Abcc1 Abcc2 Pcyt2 Slc22a2 Pcyt1a Sult1a1 Abcc3 Slc22a3 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Abcb1a Slc6a2 Slc6a4 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) Ugp2 Pgm1 Ugdh Galk1 Gale Gck Galt Uxs1 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway Cyp2c65 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway Cyp3a16 Abcb1a Pdia2 Sdf2l1 Top2a Mpo Hyou1 Ptgs1 Pdia6 Pdia4 Ptgs2 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Abcc3 Top2b OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway Atp4a Atp4b SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency Gpi Gusb Ugt8 Hk1 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis Cps1 Gad1 Glul Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Aldh4a1 Gmps Gfpt1 Qars1 Cad Ppat ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification As3mt Gsto1 Aqp9 Aqp7 Pnp Slc2a4 Slc2a1 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) Farsb Il4i1 Gstz1 Got1 Hgd Pah Tat Yars1 Farsa Fah Hpd HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism Itpk1 Synj1 Nudt3 Inpp1 Inpp4b Minpp1 Itpka Impa1 Isyna1 Ip6k1 Ppip5k1 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Sars1 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling Itpr1 Akt1 Adcy1 Rock1 Lpar2 Srf Gng2 Gnb1 Plcb1 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway Klb Fgf15 Slc10a2 Nr1h4 Fgfr3 Fgfr4 Fgfr1 Fgfr2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease Gapdhs Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Hk1 Tpi1 EG433182 Galm Slc2a13 Pgk2 Aldob PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell Sntb1 Abcc8 Cacnb1 Cacna2d2 Scn5a Cacna1a Slc2a2 Gcg Snta1 Sntb2 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria Pfkfb1 Gmppb Gmds Phpt1 Fcsk Fpgt Gfus Pfkl Hk1 Fbp1 Tpi1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids Pex14 Crat Cpt2 Pex13 Abcd2 Crot Pex11g Slc25a20 Acsl1 Abcd1 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin Mylk Gngt1 Prkacb Ptgir Gnb1 Myl3 Adcy2 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 Ikbkb Mapk14 Traf6 Ikbkg Mapk8 Nfkbia Map3k1 Nfkb1 Ecsit Tollip Chuk Irak1 Tlr1 Tlr9 Tab3 Tlr8 Tab2 Tlr7 Tlr6 Tab1 Tlr5 Tlr3 Tlr2 Rela Map3k7 Myd88 Ly96 Cd14 Tirap Tlr4 Map2k4 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway Cyp3a16 Abcb1a Abcg2 Pdia2 Sdf2l1 Abcc1 Abcc2 Hyou1 Pdia6 Pdia4 Bche Ppib Dnajb11 Ces2h Ces1d Top1 Ugt1a9 Erp29 Ugt1a1 Hspa5 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Taldo1 Tktl1 Pfkm Rbks Rpe Pgd Dera Aldob QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis Ppcs Ppcdc Coasy Enpp1 Pank1 Vnn1 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway Rpia Gpi Pfkl Taldo1 G6pdx Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgm1 Pgd Dera Pgls TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb Echs1 Acat1 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Sars1 Agxt Psph Cth Aldh2 Shmt1 Sds Gatm Gldc MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway Agt Ace 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine Map2k6 Ikbkb Rps6ka1 Mapk8 Nfkbia Map3k1 Bad Nfkb1 Elk1 Chuk Map2k7 Jun Atf2 Pak1 Arhgef7 Adora2a Braf Map3k4 Nfkb2 Hras Mapk1 Prkcz Pik3ca Rap1a Pard6a Rapgef3 Rapgef2 Mapk11 Akt1 Creb1 Gngt1 Prkacb Map2k2 Pdpk1 Gnb1 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor Itpr1 Prkca Gnaq Plcb1 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria Gstz1 Aldh3a1 Maoa Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary Slc46a1 Mthfd1l Mtfmt Aldh1l1 Mthfsl Fpgs Dhfr Mthfd1 Mthfd2 Ftcd Mthfr SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Mcee Echs1 Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria Hadha Hadhb Hsd17b10 Acaa2 Echs1 Mecr Ppt1 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Tars1 Rps14 Rpl4 Rps16 Rps15a Rps18 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect Glud1 Pkm Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 EG433182 Pgam2 Suclg1 Mdh1 Pklr Mpc1 Fh Idh1 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Rpia Gpi Pfkl Taldo1 Pgk1 G6pdx Tkt Slc1a3 Hk2 Gls Slc16a1 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism Ugp2 Pgm1 Ugdh Galk1 Gale Gck Galt Uxs1 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps15 Rps17 Rpl15 Rpl8 Rps20 Rps24 Rps14 Aars1 Rpl4 Rps16 Rps15a Rps18 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway Abcc2 Trp53 Tubb1 Cdkn1a Cyp3a16 Abcc10 Abcb1a Ralbp1 Abcc3 Abcc1 Tuba1b QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway Ace CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Adra1a Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway Agt Ace BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism Nudt11 Prex1 Ipmk Inppl1 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Sars1 Agxt Psph Cth Aldh2 Shmt1 Sds Gatm Gldc LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis Coq5 Coq6 Coq7 Coq2 Coq3 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease Pck1 G6pc1 Gpi Fbp1 Tpi1 Aldoa Mdh2 Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB Pck1 G6pc1 Gpi Fbp1 Tpi1 Aldoa Mdh2 Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease Agl Ugp2 Pygl Ugdh Gpi Ugt2b1 Amy2a5 Gusb Hk2 Gck Pgm2l1 AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) Dlat Dld Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Mdh1 Suclg1 Mpc1 Suclg2 Fh Idh3a Dlst Pdhb Idh3b Aco2 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia Aldh3a1 Maoa Aoc1 Uroc1 Hdc Amdhd1 Hnmt Carnmt1 Hars1 Prmt3 Cndp2 Carns1 Hars2 Aldh2 Ftcd Hal Cndp1 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway Cyp3a16 Cyp2c50 Pde4d MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) Gstz1 Aldh3a1 Maoa Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids Hadha Hadhb Hadh Acadm Acaa2 Slc25a20 Echs1 Acsm1 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism Sult1a1 Chst11 Sult2b1 Suox Papss2 Bpnt1 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism Hsd11b1 Akr1d1 Srd5a1 Hsd17b3 Pdia2 Akr1c6 Cyp19a1 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Cyp11b1 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway Aldh1a1 Gstm2 Cyp3a16 Aldh3a1 Cyp2c50 Cyp2b10 Cyp2a5 Cyp2c65 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Egln2 Idh3g Pdha1 Egln3 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 Dlat Aco1 Dld Slc25a10 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway Kdr Flt1 Vegfa NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway Ugt1a2 Pdia2 Ugt2b36 Sdf2l1 Hyou1 Pdia6 Pdia4 Oprm1 Ppib Dnajb11 Ugt1a9 Ugt2b1 Erp29 Ugt1a1 Hspa5 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency Rpia Fbp2 Gpi H6pd Prpsap1 Taldo1 Tktl1 Pfkm Rbks Rpe Pgd Dera Aldob KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway Cyp3a16 Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Cyp1a2 Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis Pcyt2 Pisd Cept1 Chka Ptdss1 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Yars1 Rps14 Rpl4 Rps16 Rps15a Rps18 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis Gapdhs Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Hk1 Tpi1 EG433182 Galm Slc2a13 Pgk2 Aldob LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism Itpk1 Vac14 Inpp1 Minpp1 Pik3r4 Pik3c3 Fig4 Pik3ca Ambra1 Itpka Miox Ptpmt1 Inpp4a Pi4ka Ipmk Pikfyve Ippk Impa1 Isyna1 Plcd3 Becn1 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis Cyp2u1 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway Ehhadh Hadha Ugt1a2 Hadhb Hsd17b10 Ivd Cyp2b10 Cyp2a5 Acadsb Acsm1 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Dars1 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance Atp1a2 Atp1a1 Atp1b1 Atp1b3 Atp1a3 Atp1b2 Lct Slc2a2 Slc5a1 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway Agt Ace METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway Sntb1 Scn5a Snta1 Sntb2 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg F2 F3 F5 F7 F8 F9 Ggcx F13b 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway Aldh1a1 Cyp3a16 Abcc10 Cyp2d22 Cyp2b10 Ugt1a9 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway Adam17 Egfr Prkca Erbb4 Erbb3 Psen1 Nrg2 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway Cap1 Ccnd3 Pcna Cdkn1a Wasf1 Pak1 Ccnd1 Cfl1 Ppp1r12b Actb Cdk5 Myl2 Limk1 Pdgfra Vav3 Arfip2 Ralbp1 Pld1 Map3k1 Mylk Rac1 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism Dao TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation Cbs Cth KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis Bpgm G6pc1 Pgam1 Gpi Pgk1 Pfkm Aldoa Slc2a2 EG433182 Pgam2 Galm Pklr Hk2 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis Gpi Gusb Ugt8 Hk1 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway Tnf Tradd Ikbkb Traf6 Ikbkg Tnfrsf1b Tnfrsf1a Nfkbia Ncoa3 Map3k1 Camkk2 Il1a Nfkb1 Il1r1 Chuk Map3k14 Irak1 Ubc Tab1 Rela Map3k7 Camkk1 Myd88 Tlr4 Fadd Ripk1 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism Actb GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb Echs1 Acat1 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Cyp2b10 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Cyp2c65 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp3a13 Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Atp1b2 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway Cckbr Sst Hrh2 Gast Atp4a Sstr4 Atp4b Chrm3 Ca1 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect Glud1 Pkm Pcx Sdhc Sdhb Cs EG433182 Pgam2 Idh3g Pdha1 Suclg1 Mdh1 Mpc1 Suclg2 Fh Pgls Idh1 Idh3a Dlst Pdhb Idh3b Aldob Aco2 Aco1 Dld Rpia Gpi Pfkl Pgk1 G6pdx Tkt Slc2a2 Slc1a5 Pdhx Ogdh Slc16a1 CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL Trp53 Grb2 Stat5a Pik3r1 Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism Fads2 Elovl4 Elovl5 Fads1 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism Fech Uros Hmox1 Ppox Cox10 Flvcr2 Blvra Alad Hmbs Alas1 Ftmt Cox15 Cpox Urod Gusb ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Hsd17b1 Ugt2b38 Cyp19a1 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism Aldh7a1 Bhmt Ahcy Mtr Pemt Mat2b Mat2a Chdh BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency Btd Hlcs Acacb Spcs1 FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway Agt Ace ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Cars1 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL Trp53 Grb2 Stat5a Pik3r1 Sos1 Jak2 Bad Bcl2l1 Gab2 Cbl Crkl Myc Mdm2 Cdkn1b Crk Skp2 Mtor PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency Agxt Gpt Mpc1 Pcx Aars2 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway Egfr FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway Abcc2 Cyp3a16 Ces2h Impdh1 Ces1d Ugt1a9 Slco1b2 Abcb1a Abcg2 Cyp2c65 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism Aldh1a1 Cyp3a16 Cyp2b10 Cyp2a5 Pdia2 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 Dhrs4 Dhrs3 Aldh1a2 Awat1 Rdh8 Rdh11 Rdh12 Dhrs9 Bco1 Rpe65 Rdh16f2 Cyp26a1 Cyp3a57 Cyp3a13 Dgat1 Retsat Lrat DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Atp1b2 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency Gstz1 Aldh3a1 Maoa Ddc Pnmt Aoc1 Got1 Hgd Haao Mif Dbh Tyr Fah Comt Dct CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway P2ry12 Cyp3a16 Cyp2c50 Cyp1a2 Cyp2b10 Pon1 Abcb1a TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis Duox1 Tpo Tg Cyba Cybb Nox4 Nox3 Duox2 Slc5a5 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation Pmm2 Pfkfb1 Tgds Phpt1 Amigo3 Fcsk Fpgt Gfus Pfkl Fbp1 Tpi1 Mpi Akr1b1 Sord Aldob Khk INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine Map2k6 Ikbkb Rps6ka1 Mapk8 Nfkbia Map3k1 Bad Nfkb1 Elk1 Chuk Map2k7 Jun Atf2 Adora2b Pak1 Arhgef7 Braf Map3k4 Nfkb2 Hras Mapk1 Prkcz Pik3ca Rap1a Pard6a Rapgef3 Rapgef2 Mapk11 Adcy2 Akt1 Creb1 Gngt1 Prkacb Map2k2 Pdpk1 Gnb1 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome Bpgm G6pc1 Pgam1 Gpi Pgk1 Pfkm Aldoa Slc2a2 EG433182 Pgam2 Galm Pklr Hk2 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell Sst Abcc8 Cacnb1 Cacna2d2 Cacna1a Slc2a2 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling Slc7a5 Irs1 Insr Tsc2 Eif4ebp1 Tsc1 Eif4e Ins2 Akt1 Pik3r6 Pik3cg Irs2 Mtor HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency Dhfr Cbr1 Qdpr Gch1 Spr Akr1b1 Pts Gchfr SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency Acat1 Hmgcl Bdh1 Oxct1 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling P4ha3 Tlr4 Hif1a Il1b Sirt3 Nlrp3 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC Pck1 G6pc1 Gpi Fbp1 Tpi1 Aldoa Mdh2 Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway Cyp3a16 Ugt1a9 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency Dlat Pck1 Dld Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway Ace NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Oprk1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin Creb1 Gngt1 Prkacb Ppp1ca Htr4 Gnb1 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism Cyp1a1 Sult1e1 Hsd17b1 Pdia2 Sdf2l1 Comt Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Erp29 Ugt1a1 Hspa5 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb Echs1 Acat1 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway Egfr NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway Itpr1 Map2k3 Egfr Mapk14 Cacna2d2 Sos1 Mapk8 Map3k1 Elk1 Map2k7 Jun Map2k1 Grb2 Raf1 Cacna1c Cacna1f Cacna1d Hras Mapk1 Cacna1s Pld1 Map3k2 Gna11 Src Fshb Lhb Gnrh1 Adcy1 Prkcb Gnrhr Hbegf Camk2a Cacnb1 Cga Prkca Egr1 Mmp14 Lrrc7 Mmp2 Prkaca Actn4 Plcb1 Atf4 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway Tyms INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism Itpk1 Vac14 Sacm1l Minpp1 Pik3r4 Pik3c3 Cct3 Ambra1 Plcd1 Itpka Miox Ptpmt1 Inpp4a Ipmk Ippk Impa1 Bpnt1 Isyna1 Inpp5j Becn1 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) Hadha Hadhb Gcdh Acadl Cpt2 Acads Acadm Acadvl Acaa2 Cpt1a Acsl1 Acadsb Echs1 Acat1 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 Map2k6 Map2k3 Ikbkb Mapk14 Traf6 Ikbkg Mapk8 Nfkbia Map3k1 Nfkb1 Ecsit Elk1 Tollip Chuk Irak1 Tlr9 Tab2 Tlr7 Jun Tab1 Tlr3 Fos Tlr2 Rela Map3k7 Myd88 Ly96 Eif2ak2 Cd14 Ppara Tirap Tlr4 Map2k4 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis Pgs1 Agpat5 Gpam Gpd1 Crls1 Cds2 Ptpmt1 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway Nfatc4 Nfatc1 Nfatc3 Nfatc2 Sos1 Ppp3cc Mapk8 Nfkbia Shc1 Map3k1 Ptpn7 Cd3g Cd247 Nfkb1 Elk1 Cd3d Mapk3 Ubc Fyn Pik3cg Rac1 Ppp3ca Vav1 Jun Ppp3cb Fos Rela Map2k1 Lck Grb2 Rasgrp1 Raf1 Pik3r1 Lat Hras Pik3ca Zap70 Cd3e Map2k4 Prkcb Plcg1 Prkca MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway Slc29a2 Slc28a2 Impdh1 Slc28a3 Slc29a1 Abcc4 Abcc5 Xdh Gmps Hprt1 Rac1 Aox1 Adk Tpmt Ppat FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway Cacna1c Cacnb1 Cacna2d2 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway Prkcb P2ry2 Plcg1 Ptk2b Prkca MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type Mat2a Chdh Msrb3 Msrb2 Il4i1 Srm Dnmt1 Mtap Bhmt Cbs Cth Mars1 Shmt1 Mat2b Mthfr MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) Nt5c2 Tyms Gda Rrm2b Dhodh Tymp Dctd Cda Upb1 Dut Dpys Ctps1 Ak3 Cmpk2 Upp2 Dpyd Tk1 Itpa Uckl1 Rrm2 Cant1 Cad Nme6 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway Itpr1 Nos1 Dlg4 Grin2a Xdh Aldh2 Prkacb Prkca Ppp3ca Grin1 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect Glud1 Pkm Pcx Pfkp Sdhd Sdhc Hk1 Sdhb Sdha Cs Dhtkd1 EG433182 Pgam2 Pdha1 Suclg1 Mdh1 Mpc1 Pgd Suclg2 Fh Pgls Idh1 Idh3a Dlst Pdhb Dlat Tktl2 Aco1 Dld Slc16a4 Rpia Gpi Taldo1 Pgk1 G6pdx Gls Slc2a1 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia Pdxp Pnpo Aox1 Pdxk Alpl PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency Cps1 Gad1 Glul Gss Gsr Ears2 Gls2 Gclc Glud1 Abat Gclm Got2 Gpt Nagk Gnpnat1 Aldh4a1 Gmps Gfpt1 Qars1 Cad Ppat JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome Erbb2 Vac14 Synj1 Inpp4b Pik3c2a Pten Pik3r4 Pik3c3 Egfr Pik3r1 Fig4 Cdipt Ambra1 Pik3cd Pip5k1a Pip4k2a Pi4ka Pikfyve Inpp5d Inpp5e Plcb1 Becn1 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway Cyp3a16 Grin2a Cyp2c50 Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cyp2d22 Cacnb1 Atp1b1 Atp1b3 Atp1b2 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic Mpst Ctns Cdo1 Cth Cars1 Gclc Gclm Got1 Ldha BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) Slco1a4 Slc10a2 Nr1h4 Gpbar1 Abcc4 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids Pex14 Crat Phyh Cpt2 Pex13 Abcd2 Aldh2 Hacl1 Slc25a20 Acsl1 Abcd1 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease Pck1 G6pc1 Gpi Fbp1 Tpi1 Aldoa Mdh2 Pank4 EG433182 Pgam2 Slc25a11 Galm Mpc1 Hk2 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome Nme2 Lalba Ugp2 G6pc1 B4galt1 Cmpk1 Cant1 Galt Slc35a2 Slc2a1 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway Tyms DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway Grin2a Kcnd2 Scn1b Chrnb2 Cacna2d2 Pomc Drd1 Grin1 Slc6a2 Slc6a4 Slc6a3 Adra1a Scn10a Pcsk2 Chrna4 Oprm1 Htr1a Atp1a2 Atp1a1 Atp1a3 Cacna1a Cacnb1 Atp1b1 Atp1b3 Atp1b2 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway Cyp3a16 Cyp2b10 Pdia2 Cyp2c65 Sdf2l1 Hyou1 Pdia6 Pdia4 Ppib Dnajb11 Ugt1a9 Erp29 Ugt1a1 Hspa5 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 Dlat Pck1 Dld Pcx Acat1 Pdha1 Acaca Grhpr Mdh1 Pklr Aldh2 Glo1 Ldhd Acss2 Ldha Me1 Akr1b1 Pdhb Hagh Acyp1 Acot12 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I Hmgcs2 Mccc1 Acad8 Ivd Hibadh Mccc2 Aldh2 Dld Hibch Aldh6a1 Acads Acadm Acaa2 Abat Bckdhb Acadsb Echs1 Pcca Bckdha Pccb Dbt Acat1 Hsd17b10 Bcat1 Auh Aox1 Hmgcl Oxct1 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism Sptlc1 Cerk Sptlc2 Degs2 Gba1 Ugt8 Sphk2 Ugcg Arsa Acer1 Plpp1 Sgpl1 Gal3st1 Acer3 Enpp7 Galc Neu3 B4galt6 Sgms1 Glb1 Kdsr Sgpp2 Gla 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) Cyp11a1 Cyp17a1 Hsd11b1 Hsd11b2 Akr1d1 Hsd3b6 Cyp21a1 Cyp11b1 Hsd3b1 Akr1c6 Cyp11b2 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Sars1 Agxt Psph Cth Aldh2 Shmt1 Sds Gatm Gldc DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency Amt Dld Maoa Gars1 Psat1 Phgdh Gcat Gnmt Srr Alas1 Dmgdh Glyctk Shmt2 Sardh Sars1 Agxt Psph Cth Aldh2 Shmt1 Sds Gatm Gldc GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis EG433182 Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production Gngt1 Mc2r Prkacb Pomc Gnb1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Gpi Gusb Ugt8 Hk1 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway Aldh1a1 Cyp3a16 Aldh3a1 Cyp2b10 Cyp2a5 Cyp2c65 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway Atp4a Atp4b NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway Nos1 Dlg4 Grin2a Calm1 Prkacb Prkca Ppp3ca Grin1 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway Arnt Ahr Hsp90aa1 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway Map2k1 Grb2 Raf1 Stat5a Rasa1 Srf Hras Egf Stat3 Jak2 Mapk8 Shc1 Map3k1 Elk1 Map2k7 Prkcb Mapk3 Plcg1 Prkca Jun Erbb4 Fos LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling Akt1 Adcy1 Rock1 Srf Lpar6 Gng2 Gnb1 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation Pfkfb1 Gmppb Gmds Phpt1 Fcsk Fpgt Gfus Pfkl Hk1 Fbp1 Tpi1 Aldoa Pmm1 Mpi Akr1b1 Sord Aldob Khk GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease Gpi Gusb Ugt8 Hk1 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease EG433182 Pgam2 Galm G6pc1 Pklr Gpi Hk2 Pfkm Tpi1 Aldoa PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) P4ha3 Nos1 Cps1 Ckb Asl Otc Glud1 Got1 Oat Arg1 Aldh4a1 Pycr2 Eprs1 Prodh Ass1 Gatm Dao Rars2 Slc25a15 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis Amacr Acox2 Hsd17b4 Baat Cyp39a1 Hsd3b7 Cyp27a1 Cyp46a1 Akr1d1 Lipa Scp2 Slc27a5 Cyp8b1 Cyp7a1 Cyp7b1 Akr1c6 Ch25h ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway Cyp3a16 Cyp2d22 Cyp2c50 Cyp1a2 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway Cyp3a13 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation Fbp2 Aldoc Pfkm Hk1 Tpi1 Aldob PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Hars1 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency Rpia Gpi Pfkl Taldo1 G6pdx Tkt Fbp1 Aldoa Rbks Rpe Prps1l1 Pgm1 Pgd Dera Pgls DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway Cyp2d22 Slc6a2 Slc6a4 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway Slc22a2 Nr3c2 Slc22a6 Scnn1a Scnn1b Scnn1g Slc1a1 Slc3a1 Slc38a4 Slc12a6 Slc3a2 Slc7a6 Slc7a7 Slc12a1 Slc7a5 Slc14a2 Slc7a8 Slc12a3 Slc7a9 Atp1a2 Slc6a20a Clcnkb Atp1a1 Atp1a3 Atp1b1 Atp1b3 Atp1b2 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin Lhb Creb1 Gngt1 Prkacb Cga Lhcgr Ppp1ca Gnb1 Adcy2 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation Atp1a2 Atp1a1 Atp1b1 Atp1b3 Atp1a3 Atp1b2 Lct Slc2a2 Slc5a1 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency Pck1 Bpgm G6pc1 Pgam1 Gpi Pcx Fbp1 Tpi1 Aldoa Slc2a2 Mdh2 EG433182 Pgam2 Slc25a11 Galm Pgm1 Mpc1 Hk2 Ldha Pank1 Slc37a4 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism Plpp1 Gpam Aldh3a1 Gpd1 Lipc Agpat1 Lpl Akr1b1 Gpd2 Plpp2 Glyctk ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation Gpi Pkm Pfkp Tpi1 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway Prps1 Rpia Gpi Pfkl Taldo1 G6pdx Tkt Fbp1 Aldoa Rbks SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency Ugp2 Gpi Mgam Gbe1 Gys2 Sis Pgm2l1 Agl Pygl Pgm1 Ugdh Amy2a5 Gusb Hk2 Gck TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis Dgat1 Gpam Gpd1 Lpin1 Agpat1 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency Cbs Cth HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway Atp4a Atp4b VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway Agt Agtr1a Gng2 Gnaq Gnb1 Ace CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia Dpyd Gad1 Aldh6a1 Aldh2 Abat Upb1 Aoc3 Dpys Cndp1 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease Agl Ugp2 Pygl Ugdh Gpi Ugt2b1 Amy2a5 Gusb Hk2 Gck Pgm2l1 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation Dhtkd1 Dld Acmsd Aldh8a1 Dlst BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Wars1 Rps14 Rpl4 Rps16 Rps15a Rps18 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism Itpk1 Nudt3 Inpp4b Inpp1 Minpp1 Itpka Inpp4a Ipmk Ippk Impa1 Ip6k1 Isyna1 Ppip5k1 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway Vkorc1 Fgb Fga Col1a1 F10 F12 F11 Fgg F13a1 Klkb1 Plat Plg Serpinc1 F2 F3 F5 F7 F8 F9 Ggcx F13b SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II Slc25a2 Aldh7a1 Dld Gcdh Aadat Pipox Slc7a2 Aass Echs1 Dhtkd1 Acat1 Hadh Dlst ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action Itpr1 Nfkb1 Prkcb Hrh1 Gng2 Gnaq Gnb1 Plcb1 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria Dld Hibch Ldhal6b Aldh6a1 Acadm Abat Acss1 Bckdhb Mcee Echs1 Pcca Mlycd Bckdha Pccb Dbt Acat1 Acaca AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency Cyp17a1 Akr1d1 Sult1e1 Sult2b1 Hsd3b6 Srd5a1 Hsd17b3 Hsd17b1 Ugt2b38 Cyp19a1 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC Gapdhs Bpgm G6pc3 Slc25a18 Pgam1 Pck2 Fbp2 Gpi Hk1 Tpi1 Mdh2 Pank4 EG433182 Galm Mpc1 Slc2a13 Cad Aldob KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule Slc12a3 Atp1a2 Clcnkb Atp1a1 Atp1a3 Atp4a Aqp3 Atp4b Aqp2 Slc8a1 Atp1b1 Atp1b3 Atp1b2 Trpv5 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria Cps1 Asl Otc Gls2 Glud1 Got2 Gpt Slc25a12 Arg1 Slc1a5 Slc1a4 Ass1 Slc25a15 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway Ace PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway Kcne1 Sntb1 Kcnj3 Kcnj2 Dlg1 Abcc8 Kcnj11 Abcc9 Cacna2d2 Ryr2 Cacna1g Cacna1h Hcn4 Atp1a2 Cacna1c Atp1a1 Prkar1a Atp1a3 Atp2a2 Scn5a Kcnd3 Kcnj8 Snta1 Kcnj5 Kcnh2 Kcnj4 Chrm2 Kcnk1 Kcnq1 Slc8a1 Adrb1 Cacnb1 Atp1b1 Atp1b3 Atp1b2 Kcna5 Tpm2 Prkaca Kcne2 Sntb2 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells Tnf Mapk8 Gab2 Map2k7 Fyn Rac1 Syk Il13 Fcer1a Il4 Map2k1 Lyn Lck Kras Grb2 Blnk Ms4a2 Raf1 Nras Pik3r1 Lat Csf2 Hras Mapk1 Akt1 Plcg1 Prkca Map2k2 Inpp5d SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation Ikbkb Mapk1 Nos3 Ikbkg Mapk11 Nfkb1 Ptgs1 Chuk Creb1 Mapk3 Prkca Sucnr1 Plcb1 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway Cyp3a16 Cyp2d22 Sult1a1 Cyp2b10 Fmo1 Ugt1a9 Fmo3 Esr1 Ugt1a5 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 Ampd1 Paics Nt5c2 Ada Prps1l1 Pde10a Adsl Gda Impdh1 Txn Aprt Gucy1b1 Pnp Entpd5 Guk1 Pde4d Nudt2 Entpd8 Adcy2 Gart Itpa Nudt5 Dguok Rrm1 Xdh Rrm2 Ak1 Gmps Gmpr Hprt1 Adss2 Pfas Atad1 Gucy1a2 Atic Nme6 Ppat D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway Casp3 Prf1 Arhgdib Arhgap32 Apaf1 Gzmb Parp1 Jun Casp8 Casp9 Arhgap5 Casp1 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria Fbp2 Aldoc Pfkm Hk1 Tpi1 Aldob ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria Gss Gsr Gclc Gclm Gpx1 Ggt6 Gsto2 Anpep Oplah Casp7 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway Alox15 Cyp4f17 Cyp4f15 Ptgds Cyp2j6 Cyp4f3 Cyp2b10 Cyp4a32 Ggt1 Ltc4s Tbxas1 Gpx1 Ptges Ptgis Cyp2c65 Cyp2e1 Ephx2 Ptgs1 Alox12b Ptgs2 Cbr1 Alox8 Alox12 Prxl2b Cyp2u1 Alox5 Lta4h Akr1c18 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine Rps19 Rpl18a Rpl37 Rpsa Rps10 Rpl17 Rpl39 Rpl18 Rps11 Rpl19 Rpl7 Rpl32 Rpl11 Rps3 Rps25 Rps4x Rps26 Nars1 Rps9 Rps27 Rps7 Rps5 Rpl24 Rplp2 Rpl26 Rack1 Rps21 Rpl22 Rplp1 Rpl23 Rpl13a Rps14 Rpl4 Rps16 Rps15a Rps18 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome Gapdhs Bpgm G6pc3 Pgam1 Gpi Pkm Pfkp Hk1 Tpi1 EG433182 Galm Slc2a13 Pgk2 Aldob INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine Hrh2 Creb1 Gngt1 Prkacb Ppp1ca Gnb1 Adcy2 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis Fdps Idi1 Hsd17b7 Nsdhl Mvk Dhcr24 Soat1 Lipa Fdft1 Lss Sqle Tm7sf2 Ebp Pmvk Ggps1 Sc5d Hmgcr Cyp51a1 Mvd Msmo1 Acat2 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling Itpr1 Lpar3 Akt1 Adcy1 Gng2 Gnb1 Plcb1 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate Dlat Aco1 Dld Gls2 Pcx Sdhd Sdhc Sdhb Sdha Cs Dhtkd1 Idh3g Pdha1 Suclg1 Mpc1 Suclg2 Fh Idh1 Idh2 Idh3a Dlst Pdhb Idh3b Aco2 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260810%WP458%MUS MUSCULUS Inflammatory response pathway Zap70 Fn1 Il2ra Il2rb Il2 Tnfrsf1b Il4 Vtn Tnfrsf1a Il5 Ifng Lamb2 Cd40lg Cd28 Lamb1 Cd86 Col1a2 Col3a1 Cd40 Col1a1 Cd80 Lama5 Il2rg Lck Il4ra Il5ra Lamc1 Lamc2 Thbs1 Thbs3 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260810%WP3673%MUS MUSCULUS Hfe effect on hepcidin production Id1 Bmp6 Hamp Smad7 Tmprss6 Hjv Hfe DISTAL CONVOLUTED TUBULE 1 DCT1 CELL%WIKIPATHWAYS_20260810%WP4183%MUS MUSCULUS Distal convoluted tubule 1 DCT1 cell Wnk1 Stk39 Cab39 Slc12a3 Wnk4 Kcnj16 Clcnkb TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260810%WP386%MUS MUSCULUS Triacylglyceride synthesis Agpat1 Agpat2 Gnpat Gk Mogat1 Lpl Mogat2 Plpp2 Plpp3 Pnpla2 Gk2 Plpp1 Dgat2 Agpat5 Lipc Gpam Dgat1 Agps Lipe Gpd1 Lipf Agpat3 Agpat4 WNT SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP539%MUS MUSCULUS Wnt signaling pathway Mapk9 Mapk8 Mapk1 Ctnnb1 Map3k7 Mapk3 Pias4 Sox1 Wnt5a Cdh1 Myb Akt1 Sox9 Tax1bp3 Cxxc4 Skp1 Ppp2ca Daam1 Dkk1 Prkcb Magi3 Axin1 Axin2 Prkca Ror2 Crybb2 Btrc Sall1 Raf1 Cdc25c Senp2 Vangl2 Ruvbl1 Nlk Dab2 Tfap2a Wnt3a Dvl1 Dvl2 Dvl3 Wnt2 Wnt1 Wnt4 Wnt3 Fzd1 Jun Fzd2 Fzd5 Jup Fzd4 Ccnd1 Fzd7 Fzd6 Fzd9 Fzd8 Bcl9 Smad3 Dlg1 Smad4 Dlg2 Dlg4 Cul1 Cdk1 Pin1 Tcf4 Tcf3 Csnk2a2 Fhl2 Csnk2a1 Rhoa Mark2 Ctbp1 Ctbp2 Rac1 Sfrp2 Sfrp1 Csnk2b Tbp Pax2 Gsk3b Csnk1d Csnk1e Lef1 Lrp1 Sumo1 Lrp6 Ep300 Csnk1a1 Lrp5 Camk2g Nkd1 Camk2d Camk2b Camk2a Arrb2 Arrb1 Wnt7a Brd7 Runx2 Map1b Ctnnbip1 Ankrd6 Apc Mapk8ip1 Frat2 Frat1 Hipk2 Nr5a1 P38 MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP350%MUS MUSCULUS p38 Mapk signaling pathway Atf2 Shc1 Max Map3k9 Pla2g4a Hmgn1 Elk1 Mef2d Map3k5 Map2k6 Tgfb2 Tradd Myc Hspb1 Traf2 Cdc42 Creb1 Mapkapk2 Mapk14 Ddit3 Ripk1 Rasgrf1 Map2k4 Rps6ka5 Map3k7 Map3k1 Mknk1 Stat1 Grb2 Tgfbr1 Rac1 Daxx Hras TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260810%WP3625%MUS MUSCULUS Tyrobp causal network in microglia Tgfbr1 Adap2 Ncf2 Il18 Itgax Sft2d2 Cytl1 Tmem106a Itgam Rgs1 Lyl1 Dpyd Il13ra1 Cd84 Gpx1 Nckap1l Hcls1 Kcne3 Abcc4 Maf Bin2 Npc2 Elf4 Lhfpl2 Itgb2 Rps6ka1 Cd37 Samsn1 Tyrobp Creb3l2 Ppp1r18 Il10ra Zfp36l2 Apbb1ip C3 Rbm47 Cd4 Fkbp15 Hlx Rnase6 Tcirg1 Spp1 Slc1a5 Runx3 Loxl3 Gapt Slc7a7 Pycard Plek Capg Sh2b3 Igsf6 Stat5a Nrros Gal3st4 Cxcl16 Tnfrsf1b C1qc WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260810%WP3857%MUS MUSCULUS Wnt signaling in kidney disease Wnt7a Wnt3a Dvl1 Dvl2 Apc Dvl3 Wnt2 Wnt1 Wnt4 Wnt3 Fzd1 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Mapk9 Mapk8 Wnt11 Ctnnb1 Lrp4 Rhoa Wnt6 Wnt7b Wnt5b Wnt5a Wnt9b Wnt10a Wnt10b Invs Fzd3 Kitlg Nlrp3 Wnt2b Gsk3b Mapk10 Wnt16 Axin1 Csnk1a1 Lrp5 Btrc HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260810%WP1258%MUS MUSCULUS Homologous recombination Rad54b Rad51 Pold2 Pold1 Rad50 Rad52 Pold4 Pold3 Rpa1 Brca2 Nbn Atm Mre11a GLUCURONIDATION%WIKIPATHWAYS_20260810%WP1241%MUS MUSCULUS Glucuronidation Ugt1a8 Ugt2a1 Ugt1a2 Ugt2a2 Ugt2a3 Hk1 Ugt1a5 Ugt2b1 Ugt1a1 Pgm3 Pgm2 Pgm5 Ugp2 Ugt2b34 Ugdh Pgm1 Ugt1a10 IL 2 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP450%MUS MUSCULUS IL 2 signaling pathway Shc1 Socs1 Socs3 Irs1 Irs2 Ybx1 Ets1 Shb Ets2 Plcb1 Hsp90aa1 Crkl Nfkb1 Jak3 Creb1 Foxo3 Mapkapk2 Jak2 Mapk14 Jak1 Mapk9 Stam2 Mapk8 Syk Mapk1 Gab2 Rack1 Vav1 Mapk3 Eif4e Mknk1 Rela Stat1 Tert Grb2 Ifna1 Icam1 Pik3r1 Akt1 Crk Pik3r2 Sos1 Cd53 Nr3c1 Ptpn6 Itm2b Stam Cbl Eif3b Mtor Rps6kb1 Ptpn11 Pik3cg Kras Fyn Prkcz Raf1 Pik3cb Pik3cd Lyn Pik3ca Ptk2b Nmi Map2k2 Stat5b Map2k1 Stat3 Bcl2 Chuk Cish Stat5a Il2ra Il2rb Il2 Il2rg Lck COMPLEMENT ACTIVATION CLASSICAL PATHWAY%WIKIPATHWAYS_20260810%WP200%MUS MUSCULUS Complement activation classical pathway C1qc C1qb C1qa C1ra Masp1 C3 C8b C8a C2 C4b C4a C5 C1s1 C6 C7 C9 Cd55 WNT SIGNALING%WIKIPATHWAYS_20260810%WP403%MUS MUSCULUS Wnt signaling Wnt7a Apc Frat1 Myc Mapk9 Ctnnb1 Wnt5a Prkcb Axin1 Prkca Prkcz Wnt3a Dvl1 Dvl2 Dvl3 Wnt2 Wnt1 Wnt4 Wnt3 Fzd1 Jun Fzd2 Fzd5 Ccnd1 Fzd7 Fzd6 Fzd9 Fzd8 Prkd1 Pafah1b1 Fzd10 Sfrp4 Prkcq Prkcg Prkch Prkci Prkcd Prkce Ldlr Fbxw2 Wnt11 Ppp2r5c Rhoa Wnt6 Fosl1 Wnt7b Ccnd2 Wnt5b Ccnd3 Ppp2r5e Rac1 Wnt10a Plau Wnt10b Fzd3 Gsk3b Wnt2b Mapk10 Csnk1e Wnt16 TGF BETA SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP113%MUS MUSCULUS TGF beta signaling pathway Smad1 Bmp4 Smad2 Zfyve9 Smad7 Runx2 Smad9 Bambi Inhba Smad5 Tgfbr2 Smad6 Nfkb1 Jak1 Mapk9 Ctnnb1 Mapk3 Stat1 Tgfbr1 Hras Stat3 Wnt1 Jun Spp1 Runx3 Smad3 Smad4 Ifng Fkbp1a Tnf Tgif1 Ltbp1 Fst Tfe3 Nog Itgb6 Fos Lef1 Zeb2 Zfp423 Foxh1 Serpine1 Ep300 Skil Eng Thbs1 Tgfb1 Tgfbr3 Egf Lif Crebbp BURN WOUND HEALING%WIKIPATHWAYS_20260810%WP5056%MUS MUSCULUS Burn wound healing Acta1 Nos3 Nos2 Flii Tnf Hbegf Tgfbrap1 Nlrp3 Gja1 Lama1 Col1a1 Pecam1 Vegfa Prodh2 Tgfb1 ADIPOGENESIS GENES%WIKIPATHWAYS_20260810%WP447%MUS MUSCULUS Adipogenesis genes Lpl Socs1 Socs3 Irs1 Irs2 Lipe Agpat2 Ctnnb1 Nr3c1 Stat5b Dvl1 Stat3 Wnt1 Fzd1 Smad3 Sfrp4 Tnf Serpine1 Tgfb1 Lif Bmp4 Ins1 Mef2d Gh Nampt Nrip1 Ins2 Irs4 Trib3 Ahr Irs3 Lifr Creb1 Prlr Bscl2 Cyp26b1 Ddit3 Foxc2 Agrp Twist1 Tle3 Nr1h3 Ebf1 Mif Stat1 Retn Lmna Rxra Cyp26a1 Frzb Mbnl1 Cntfr Gata3 Gata4 Rxrg Gata2 Cfd Hif1a Il6 Sp1 Ndn Id3 Cisd1 Pck1 Pck2 Egr2 Nsg1 Rora Igf1 Bmp3 Wwtr1 Bmp2 Bmp1 Hnf1a Hmga1 Stat6 Plin1 Plin2 Adipoq Epas1 Rara Slc2a4 Scd1 Foxo1 Nr2f1 Ppard Ppara Pparg Ptgis Rbl2 Rbl1 Klf15 Ncor1 Il6st Ncor2 Ucp1 Gadd45b Gadd45a Pnpla3 Cebpd Stat5a Cebpb Cebpa Ncoa2 Ncoa1 Zmpste24 Rb1 Fabp4 Osm Ppargc1a Wnt5b Lpin3 Celf1 Lpin2 Wnt10b Lpin1 Dlk1 Agt Mixl1 Mef2a Klf7 Klf6 Mef2b Mef2c Klf5 Lep Spock1 E2f1 Fas Stat2 E2f4 Srebf1 Gdf10 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260810%WP4347%MUS MUSCULUS Eicosanoid metabolism via cyclooxygenases COX Pla2g4b Ptgdr Ptgds Cyp4a12a Cyp4f14 Ptgfr Cyp4a12b Cyp4f3 Ptgdr2 Pla2g5 Cyp4a10 Akr1b1 Pla2g6 Ptgr2 Ptgr1 Tbxas1 Acox1 Acox2 Ppard Pla2g4a Hpgd Ehhadh Acox3 Ptgis Ptges Ptgir Acaa1a Ptgs1 Ptgs2 Tbxa2r Prxl2b MIR 127 IN MESENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260810%WP3991%MUS MUSCULUS miR 127 in mesendoderm differentiation T2 Lefty2 Smad2 Acvr1 Nodal Smad4 T Acvr2a Cfc1 Foxa2 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260810%WP1252%MUS MUSCULUS Amino acid conjugation of benzoic acid Acss2 Glyat MECHANISMS ASSOCIATED WITH PLURIPOTENCY%WIKIPATHWAYS_20260810%WP1763%MUS MUSCULUS Mechanisms associated with pluripotency Irs1 Nfkb1 Jak1 Rela Tert Icam1 Sos1 Mtor Ptpn11 Pik3cd Map2k1 Stat3 Prkcg Tfe3 Fos Tgfb1 Lif Crebbp Smad1 Bmp4 Smad2 Ins1 Lifr Twist1 Hif1a Sp1 Nr2f1 Rbl2 Il6st Gadd45a Ncoa1 Mef2c Klf5 Id1 Smad7 Acvr1 Nodal T T2 Znf281 Mapk1 Rcor2 Ctnnb1 Sox2 Kat5 Mapk3 Thap11 Pias4 Cer1 Sf1 Wnt5a Skic8 Cdh1 Tcl1 Akt1 Uhrf1 Ehmt2 Nobox Gata6 Ehmt1 Hcfc1 Dhx9 Dkk1 Insr Hnrnpu Zmym2 Axin1 Znf143 Kdm6b Lefty1 Cabin1 Bcam Ocln Dnmt3a Sall1 Tcf7l1 Raf1 Dnmt3l Phc1 Dnmt3b Nanog Rbpj Fgfr1 Gdf9 Tfap2a Ppp2r1a Wnt3a Rel Dvl1 Ctr9 Paf1 Gatad2a Gatad2b Cubn Ezh2 Fzd1 Ezh1 Terf2 Tfeb Ep400 Ddb1 Ptprs Hells Ccnd1 Suz12 Pbrm1 Pou2f1 Shh Ctcf Xpo4 Smad3 Esrrb Parp1 Smad4 Med12 Gab1 Nme2 Tet1 Zfx Pin1 Dazl Hck Rtn4r Rras Mtf2 Lyar Sgk1 Ctbp1 H3-3b Ctbp2 Stk40 Rybp Gbx2 Yipf2 Cd44 Leo1 Mbd3 Dpysl2 Gsk3b Cdx2 Mbd2 Satb2 Lef1 Satb1 Elp4 Sumo1 Wwp2 Ep300 Yy1 Brca1 Zscan10 Lrp5 Cdkn1a Nkd1 Dffa Nr5a2 Socs2 Nr2c1 Rif1 Zfp42 Mpl Mitf Ipo7 Kpnb1 Fgf4 Fgf5 Mycn Apc Ipo9 Ube2i Pim1 Dgka Pim3 Atf2 Cdkn2a Pias2 Tle4 Tle2 Fbxo15 Kdm1a Usp7 Mef2d Tle5 Relb Foxd3 Hira Smo Myc Perp Ncl Psen1 Sall4 Sall3 Creb1 Npr1 Tcf7 Grsf1 Jarid2 Tfap2c Tpo Niban1 Sp3 Nedd4l Tfcp2l1 Grb2 Jade1 Otx2 Tgfbr1 Pou5f1 Hras Plet1 Zfp57 Trp53 Nacc1 Kpna2 Kmt2d Dnmt1 Nppb P4ha1 Cdk2 Mdm2 Inhbb Ogt Cdc73 Sin3a Kdm4c Cers2 Hdac2 Hdac4 Zic2 Zic3 Gadd45gip1 Hdac1 Cdk2ap1 Eras Nr2f6 Utf1 Nr0b1 Ewsr1 Nr2f2 Eed Cad Hand2 Mybl2 Prkaca Kdm5c Etv5 Kdm6a Itgb1 Rcn2 Notch1 Spp1 Chd4 Smarca2 Smarca4 Smarca5 Acvr1c Myod1 Dppa4 Trim28 Atrx Trim24 Epop Rnf2 Igfbp3 Rest Zfp219 Mta1 Smarcad1 Arid3b Acvr1b Mta2 Casp3 Rbbp4 Rbbp7 Ercc5 Pten Klf4 Trim33 Kdm3a Tbx3 Klf2 Pml Bmpr2 Ssrp1 Smarcc1 Rock2 Rock1 NOD LIKE RECEPTOR NLR SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP1256%MUS MUSCULUS Nod like receptor NLR signaling pathway Cd40 Mapk8 Map3k7 Rela Ikbkb Chuk Ikbkg Erbin Ephb2 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260810%WP544%MUS MUSCULUS Exercise induced circadian regulation Cry2 G0s2 Clock Herpud1 Gfra1 Pigf Erc2 Cldn5 Ppp2cb Nr1d2 Nr1d1 H2-DMa Zfr Etv6 Ugp2 Pura Gstp2 Idi1 Dnaja1 Sumo3 Eif4g2 Stbd1 Tob1 Bmal1 Gstm3 Ppp1r3c Sf3a3 Nckap1 Vapa Ncoa4 Ucp3 Dazap2 H2bc7 Cbx3 Qki Per2 Hspa8 Per1 Klf9 Rbpms Myf6 Tab2 Tubb4a Azin1 Cebpb Sumo1 Psma4 Btg1 Cry1 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260810%WP318%MUS MUSCULUS Eicosanoid synthesis Ptgds Alox8 Alox5ap Pla2g6 Pla2g2a Alox12 Tbxas1 Alox5 Dpep1 Lta4h Alox15 Ptges2 Ptgis Pnpla8 Ptges Ggt1 Ltc4s Ptgs1 Ptgs2 DRAVET SYNDROME SCN1A A1783V POINT MUTATION MODEL%WIKIPATHWAYS_20260810%WP5298%MUS MUSCULUS Dravet syndrome Scn1a A1783V point mutation model Nfkb1 Rasgrf1 Akt1 Prr5 Mtor Cacna1a Cacna1b Rictor Fgf13 Scn1a Scn1b Gls Stxbp1 Gabra4 Grm3 Pik3ca Ppp1r1b Gabra3 Stxbp3 Gabbr1 Gabra2 Gabra1 Gabbr2 Kdr Slc2a1 Pcdh19 Slc2a3 Slc6a1 Slc16a7 Maoa Maob Slc16a1 Slc12a5 Stx8 Kcna2 Gria4 Gria3 Scn2b Kcnj3 Gria1 Chd2 Stx16 Ldha Ldhb Mlst8 Ctps2 Cacna2d3 Grin2a Kcnj9 Scn3a Scn3b Gfap Epb41l3 Slc1a3 Slc1a2 Slc38a3 Grin1 Slc17a7 Cacnb3 Tnf Cacnb4 Cacnb1 Gad1 Gad2 Scn4b Mapkap1 Kcnj10 Gabrb1 Gabrb3 Prr5l Glul Mapk11 Camk2a SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260810%WP1272%MUS MUSCULUS Selenium micronutrient network Gsr Mtr Kmo Ptgds Fads1 Cat mt-Co2 Pnpo Xdh Mthfr Selenok Tbxas1 Alox5 Ptgis Ptges Fads2 Gpx2 Gpx1 Gpx4 Selenop Gpx3 Gpx6 mt-Co1 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP88%MUS MUSCULUS Toll like receptor signaling Chuk Nr2c2 Traf3 Traf6 Eif2ak2 Ikbke Tbk1 Ticam2 Nfkb2 Irak4 Irak3 Ticam1 Casp8 Irak2 Map2k6 Irak1 Myd88 Ralbp1 Irf3 Abi1 Mal Nfkb1 Fadd Tlr4 Tirap Mapk14 Tlr3 Mxd3 Tlr2 Tab2 Casp3 Ikbkb Ikbkg DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260810%WP1498%MUS MUSCULUS Dopaminergic neurogenesis Stat3 Wnt1 Shh Foxa2 Ret Ddc Neurog2 Aldh1a1 Sox2 En2 En1 Nkx2-2 Nkx6-1 Otx2 Gli1 Gli2 Gbx2 Fgf8 Th Slc18a2 Msx1 Slc6a3 Ascl1 Lmx1a Lmx1b Neurod1 Pitx3 Cdkn1c Nr4a2 Tgfb1 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260810%WP4835%MUS MUSCULUS Peroxiredoxin 2 induced ovarian failure Prdx2 Casp3 Hsd3b3 Star Cycs Cyp11a1 Bax ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260810%WP1270%MUS MUSCULUS Endochondral ossification Bmp6 Runx2 Cab39 Vegfa Tgfb2 Stat1 Akt1 Frzb Sox9 Cdkn1c Hdac4 Ddr2 Chst11 Igf1 Fgf18 Ihh Ctsl Fgf2 Fgfr1 Gli3 Stat5b Ghr Hmgcs1 Alpl Col10a1 Sox6 Sox5 Adamts1 Mmp13 Ift88 Prkaca Adamts5 Adamts4 Mmp9 Scin Pth1r Pth Enpp1 Spp1 Nkx3-2 Calm1 Runx3 Ptch1 Slc38a2 Pthlh Col2a1 Kif3a Thra Serpinh1 Igf2 Bmpr1a Plat Timp3 Fgfr3 Bmp7 Acan Cst5 Mgp Igf1r Plau Mef2c Tgfb1 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260810%WP4351%MUS MUSCULUS Omega 9 fatty acid synthesis Fads1 Acot1 Acot2 Elovl2 Elovl3 Elovl5 Acsl1 Fasn Elovl1 Scd2 Acsl3 Acsl4 Elovl6 Fads2 SELENIUM METABOLISM SELENOPROTEINS%WIKIPATHWAYS_20260810%WP108%MUS MUSCULUS Selenium metabolism selenoproteins Selenoh Selenoi Sars1 Sepsecs Fabp1 Selenom Selenon Selenoo Dio1 Selenok Selenos Selenot Dio2 Dio3 Selenov Selenow Jun Sephs2 Secisbp2 Sephs1 Nfe2l2 Cth Trnau1ap Pstk Pou2f1 Nfkb1 Sp3 Rela Fos Selenbp2 Selenbp1 Msrb1 Sp1 Txnrd1 Txnrd3 Rpl30 Gpx2 Gpx1 Txnrd2 Gpx4 Eefsec Selenop Crem Gpx3 Scly Gpx6 Sars2 ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260810%WP1770%MUS MUSCULUS One carbon metabolism and related pathways Gsr Mtr Mthfr Cth Bcat1 Bcat2 Pcyt1b Pcyt1a Bhmt Pcyt2 Csad Dmgdh Shmt2 Bhmt2 Shmt1 Tyms Gpx5 Gpx7 Dnm1 Cept1 Chka Chkb Mat2a Pld1 Baat Gnmt Dhfr Ahcyl1 Gclc Cbs Pemt Gclm Etnk2 Gss Etnk1 Chpt1 Chdh Sod3 Sod2 Sod1 Gpx1 Agxt2 Sardh Mat1a Dnmt3a Cdo1 Gad1 Gad2 Gpx2 Gpx4 Gpx3 Gpx6 MIR302 367 PROMOTING CARDIOMYOCYTE PROLIFERATION%WIKIPATHWAYS_20260810%WP2904%MUS MUSCULUS miR302 367 promoting cardiomyocyte proliferation Lats2 Mst1 Yap1 Mob1b MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260810%WP401%MUS MUSCULUS Mitochondrial long chain fatty acid beta oxidation Hadha Pecr Acadl Eci1 Acadm Cpt2 Acads Acadvl Cpt1a Scp2 Slc25a20 Hadh Acsl1 Acsl3 Ehhadh Acsl4 RETINOL METABOLISM%WIKIPATHWAYS_20260810%WP1259%MUS MUSCULUS Retinol metabolism Rara Dhrs3 Lpl Aldh1a2 Sult2b1 Rdh8 Rdh12 Aldh1a3 Rdh10 Adh4 Adh1 Rarb Bco2 Bco1 Rarg Sult1a1 Npc1l1 Rbp7 Abcg8 Rpe65 Rxrb Cyp26b1 Abcg5 Rbp4 Scarb1 Rbp2 Cyp2e1 Aldh1a1 Retsat Rbp1 Rdh5 Crabp1 Crabp2 Rxra Cd36 Cyp26a1 Lrat Rlbp1 Rxrg PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260810%WP2573%MUS MUSCULUS Primary focal segmental glomerulosclerosis FSGS Plcg1 Cd151 Scarb2 Inf2 Itgb4 Itgb3 Myh9 Actn4 Irf6 Plaur Tln1 Vcl Podxl Myo1e Smarcal1 Itga3 Wt1 Cldn1 Jag1 Col4a3 Col4a4 Col4a5 Plce1 Ptk2 Synpo Lims1 Kirrel2 Kirrel3 Fat1 Parva Tlr4 Vim Cdkn1b Dnm1 Ctnnb1 Akt1 Dkk1 Lmx1b Cdkn1c Fyn Ctsl Itgb1 Notch1 Vtn Lamb2 Mki67 Ywhaq Ilk Pax2 Cr1l Itgav Trpc6 Cd80 Utrn Lama5 Cdh2 Ptpro Nphs2 Lrp6 Nphs1 Agrn Cd2ap Lrp5 Nck1 Tgfb1 Cdkn1a Pcna Mme Dag1 Camk2b Krt8 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260810%WP1496%MUS MUSCULUS Oxidative damage response Bcl2 C1qb Traf3 C1qa Traf6 C1ra Map3k9 C2 C4b C5 C1s1 Traf2 Gadd45a Nfkb1 Cdc42 Cdkn1b Cr2 C5ar1 Bag4 C3ar1 Tnfrsf1b Bak1 Map2k4 C1qc Traf1 Mapk13 Map3k1 Nfkbie Casp9 Bad Casp3 Tnk2 Cyct Tdp2 Tnf Apaf1 Mapk10 Cdkn1c Cdkn1a Pcna Cycs HEART DEVELOPMENT%WIKIPATHWAYS_20260810%WP2067%MUS MUSCULUS Heart development Hand1 Smad1 Irx4 Bmp4 Tbx5 Isl1 Bmp2 Pitx2 Tbx2 Hand2 Vegfa Notch1 Shh Smad4 Foxa2 Bmpr1a Foxc2 Mapk1 Ctnnb1 Fgf8 Srf Tbx10 Erbb3 Gata6 Smyd1 Gata4 Nkx2-5 Bhlhe40 Fgf10 Bmpr2 Mef2c Bmp10 Foxc1 Hey2 Foxh1 Hey1 Ptpn11 Nfatc4 Nfatc1 Vegfc Nfatc3 Vegfb Nfatc2 Tbx20 BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260810%WP460%MUS MUSCULUS Blood clotting cascade Plat Fgb Fga F8a1 F10 Vwf F12 Plau Fgg F11 Plg F2 F5 F7 F8 F9 Serpinf2 F13b Serpinb2 Serpine1 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260810%WP175%MUS MUSCULUS Acetylcholine synthesis Pemt Chka Ache Pdha1 Pcyt1a Pdha2 Chat SPHINGOLIPID METABOLISM INTEGRATED PATHWAY %WIKIPATHWAYS_20260810%WP4690%MUS MUSCULUS Sphingolipid metabolism integrated pathway Plpp3 Plpp1 Sgpl1 Smpd1 Cers6 Cers5 Cers4 Cers3 Asah1 Cers1 Sgms1 Sgms2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Degs1 Gdf1 Sphk2 Sphk1 Kdsr Sgpp2 Ugcg Sgpp1 Cers2 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260810%WP164%MUS MUSCULUS Glutathione metabolism Gsr Gclc Dpep1 Gclm Ggt5 Gsta1 Gss Idh1 Anpep Ggt1 Chac2 Gstm7 Ggct Gstm2 Gpx2 Gpx1 G6pdx Gpx4 Gstt2 Gstt1 Gpx3 Oplah ONE CARBON METABOLISM%WIKIPATHWAYS_20260810%WP435%MUS MUSCULUS One carbon metabolism Mtfmt Mtr Mat2b Dnmt3b Gart Folh1 Ahcy Mtrr Amt Mthfd1 Mthfd2 Mthfr Ftcd Atic Tcn2 Aldh1l1 Mthfs Bhmt Shmt2 Shmt1 Tyms Dhfr Ehmt2 Ehmt1 Dnmt1 Mat1a Dnmt3a Mthfd1l Ahcyl2 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP193%MUS MUSCULUS Hepatocyte growth factor receptor signaling Pik3ca Ptk2b Map2k2 Map2k1 Stat3 Rasa1 Src Jun Pxn Dock1 Pak1 Itgb1 Itga1 Elk1 Rap1a Rap1b Hgf Ptk2 Map4k1 Rapgef1 Met Crkl Gab1 Mapk8 Mapk1 Mapk3 Grb2 Hras Pten Crk Sos1 Fos Ptpn11 Raf1 DELTA NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP265%MUS MUSCULUS Delta Notch signaling pathway Smad1 Jag1 App Fhl1 Hivep3 Psen1 Adam17 Mfng Adam10 Numb Jak2 Ccn3 Cntf Skp2 Mapk1 Sap30 Hes6 Tle1 Mapk3 Maml3 Zfpm1 Rela Egfr Notch4 Numbl Psenen Pik3r1 Akt1 Fbxw7 Notch2 Pik3r2 Trp53 Cntfr Notch3 Psen2 Skp1 Pofut1 Ascl1 Ncstn Spen Aph1b Dtx1 Cdk2 Dll1 Hey2 Dll4 Hey1 Itch Maml1 Sin3a Maml2 Ring1 Hes1 Hdac2 Furin Hes5 Jag2 Cirsr Nfkbia Hdac1 Magea1 Rbpj Cntn1 Snw1 Lfng Wdr12 Stat3 Jun Notch1 Ncor1 Ncor2 Smad3 Smad4 Cul1 Tcf3 Gsk3b Lef1 Mef2c Lck Ep300 Yy1 Egf ANDROGEN RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP252%MUS MUSCULUS Androgen receptor signaling pathway Src Pxn Ncoa4 Mapk1 Ctnnb1 Kat5 Pias4 Rela Egfr Akt1 Nr3c1 Raf1 Map2k1 Ccne1 Stat3 Pias3 Uxt Ctdp1 Kat7 Gtf2f2 Gtf2f1 Pias1 Ccnh Jun Patz1 Flna Cdc37 Pa2g4 Ranbp9 Ccnd1 Senp1 Ube3a Cdc25b Pou2f1 Rad54l2 Ar Bag1 Smad3 Hmgb2 Gtf2h1 Smad4 Psmc3ip Cav1 Esr1 Esr2 Cdk1 Cdk9 Mmp1a Cdk7 Ywhah Fhl2 Prmt1 Rac3 Rnf14 Calr Pou2f2 Nr0b2 Plagl1 Spdef Svil Tgif1 Tmf1 Hspa1a Rnf4 Appl1 Ncoa3 Nsd1 Pnrc1 Pak6 Sry Cox5b Ep300 Runx1 Casp7 Brca1 Casp1 Stub1 Tgfb1i1 Slc25a4 Rchy1 Crebbp Ran Hipk3 Runx2 Nr2c2 Ube2i Nr5a1 Atf2 Pias2 Tle5 Casp8 Nrip1 Trp53 Il6 Mdm2 Sp1 Sin3a Igf1 Hdac1 Ghr Nr0b1 Etv5 Il6st Ncor2 Ncoa2 Ncoa1 Rb1 Casp3 Pten P53 SIGNALING%WIKIPATHWAYS_20260810%WP2902%MUS MUSCULUS p53 signaling Rrm2b Ccne2 Zmat3 Bbc3 Ddb2 Serpinb5 Shisa5 Ccnb2 Ccnb3 Ccnb1 Cd82 Ei24 Tsc2 Cdkn2a Pmaip1 Siah1b Siah1a Trp73 Rprm Gadd45g Sesn2 Sesn1 Casp8 Ccng1 Chek1 Chek2 Sesn3 Perp Ccng2 Steap3 Sfn Bid Pidd1 Adgrb1 Rrm2 Gtse1 Cop1 Cdk6 Cdk4 Mdm4 Ppm1d Atr Casp9 Cyct Apaf1 Trp53 Cdk2 Mdm2 Cycs Bax Igf1 Ccne1 Ccnd1 Gadd45b Gadd45a Cdk1 Igfbp3 Ccnd2 Ccnd3 Casp3 Pten Serpine1 Fas Thbs1 Cdkn1a Atm Rchy1 G13 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP298%MUS MUSCULUS G13 signaling pathway Pip4k2a Pik3ca Calm1 Cdc42 Rhoa Gna13 Arhgef1 Sra1 Tnk2 Was Rac1 Arhgdib Map3k4 Arhgdig Pik3r2 Iqgap1 Pak3 Iqgap2 Ppp1cb Mapk10 Rtkn Diaph1 Cfl1 Cfl2 Wasl Rock2 Rps6kb1 Rhpn2 Rock1 Sh3rf1 Cit Myl1 Limk1 Mybph Pik3cb Pkn1 Pik3cd Pfn1 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP336%MUS MUSCULUS Fatty acid biosynthesis Mecr Pcx Acss2 Pecr Ech1 Echdc3 Echdc1 Echdc2 Decr1 Acly Echs1 Acaa2 Acsl5 Acsl6 Acacb Hadh Acsl1 Scd1 Acaca Fasn Acsl3 Acsl4 TRANSLATION FACTORS%WIKIPATHWAYS_20260810%WP307%MUS MUSCULUS Translation factors Eif2ak2 Eif4g2 Eif4e Eif3b Eef1a2 Eef1d Pabpc1 Pabpc2 Eef1a1 Eef1g Eif2ak1 Eif2ak3 Eef1b Eif1a Eif5a Eif4h Paip1 Eif4b Eif3j1 Etf1 Eif3i Eif4ebp2 Eif3f Eif4ebp1 Eif3e Eif4g1 Eif3h Eif3g Eif4g3 Eif4ebp3 Eif3a Eif3d Eif3c Eif2b3 Eif2b2 Eif2b5 Eif2b4 Eif2s2 Eif2s1 Eef2k Eif2b1 Eef2 Eif1 Eif5 Eif6 Eif4a2 Eif4a1 Eif2s3x Eif2s3y EBV LMP1 SIGNALING%WIKIPATHWAYS_20260810%WP1243%MUS MUSCULUS EBV LMP1 signaling Ccl5 Map3k14 Mapk8 Mapk1 Traf1 Map3k7 Rela Chuk Traf6 Tnf Nfkb2 Irak1 Ikbkb Tradd Ikbkg Hsp90aa1 Pdlim7 Map3k3 Nfkb1 Ifnb1 Ccl20 NOTCH SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP29%MUS MUSCULUS Notch signaling pathway Cirsr Aph1a Hdac1 Dtx2 Rbpj Dtx3 Snw1 Dtx4 Lfng Dll3 Rbpjl Dvl1 Dtx3l Dvl2 Dvl3 Kat2b Kat2a Rfng Ptcra Jag1 Notch1 Ncor2 Psen1 Adam17 Mfng Numb Maml3 Ctbp1 Ctbp2 Notch4 Numbl Tnf Notch2 Notch3 Psen2 Ncstn Aph1b Dtx1 Dll1 Dll4 Maml1 Hes1 Hdac2 Hes5 Jag2 Crebbp G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260810%WP413%MUS MUSCULUS G1 to S cell cycle control Ccne2 Ccna1 Mcm7 Cdkn2a Mnat1 Tfdp2 Cdkn2b Tfdp1 Cdkn2c Pkmyt1 Cdkn2d Prim2 Prim1 Mcm3 Mcm4 Myc Mcm5 Ccng2 Mcm6 Mcm2 Cdc25a Pole2 Pola2 Cdkn1b Orc5 Orc4 Orc6 Orc1 Cdk6 Orc3 Cdk4 Orc2 Cdc45 Rpa2 Wee1 Rpa3 E2f2 E2f3 E2f5 E2f6 Trp53 Pole Cdk2 Mdm2 Cdkn1c Ccne1 Ccnh Ccnd1 Rbl1 Gadd45a Cdk1 Cdk7 Rb1 Ccnd2 Ccnd3 E2f1 Rpa1 E2f4 Cdkn1a Pcna Atm NUCLEAR RECEPTORS%WIKIPATHWAYS_20260810%WP509%MUS MUSCULUS Nuclear Receptors Nr2f6 Nr0b1 Nr1d2 Nr2f2 Nr2c2 Rara Nr5a1 Nr2f1 Ppard Ppara Pparg Rarb Ar Rarg Esrrb Thra Esr1 Esr2 Rxrb Nr1h3 Rxra Nr2e1 Hnf4a Nr3c1 Nr1i3 Nr1i2 Rxrg Esrra Thrb Vdr Rorc Nr1h2 Ror1 Nr4a2 Pgr Nr4a1 Nr5a2 Rora GLOBO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260810%WP5305%MUS MUSCULUS Globo series sphingolipid metabolism B3galnt1 B3galt5 Fut2 Gbgt1 HYPOXIA DEPENDENT PROLIFERATION OF MYOBLASTS%WIKIPATHWAYS_20260810%WP5024%MUS MUSCULUS Hypoxia dependent proliferation of myoblasts Fbxo32 Igf1 Ddit4 Mstn Smad2 Tsc1 Fgf1 Calca Trim63 Rheb Myf5 Tsc2 Akt1 Vegfa Hgf Mtor Myod1 Smad3 Myog SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260810%WP1983%MUS MUSCULUS Splicing factor NOVA regulated synaptic proteins Snw1 Gabbr2 Plcb4 Rap1gap Kcnma1 Clasp1 Cask Dab1 Kcnj6 Mapk4 Epb41l2 Clstn1 Stxbp2 Cadm3 Epb41l1 Cadm1 Gabrg2 Kcnq2 Stx2 Map4 Neo1 Cav2 Atp2b1 Chl1 Ank3 Gphn Terf2ip Mapk9 Ntng1 Epb41 Csn3 Aplp2 Epb41l3 Grik2 Ncdn Efna5 Grin2b Grin1 Cdh2 Agrn Camk2g Prkcz NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260810%WP431%MUS MUSCULUS Nuclear receptors in lipid metabolism and toxicity Rara Ppard Ppara Pparg Rarb Rarg Abcg5 Cyp2e1 Nr1h3 Abcb1a Abcd2 Cyp27b1 Cyp26a1 Abcd3 Abcb4 Cyp2b10 Cyp4b1 Nr1i3 Cyp8b1 Nr1i2 Nr1h4 Abcg1 Abca1 Vdr Abcc3 Cyp24a1 Abcc2 Cyp1a2 Cyp7a1 Abcb11 SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260810%WP1266%MUS MUSCULUS SIDS susceptibility pathways Adcyap1 Kcnh2 Chrnb4 Chrnb2 Htr2a Kcnq1 Slc6a4 Cc2d1a Avp Htr1a Phox2b Tph2 Phox2a Tph1 Nfya Nkx3-1 Vipr2 Vipr1 Pou3f2 Foxm1 Cav3 Ppargc1b Ybx1 Adcyap1r1 Cdca7l Il6ra Tlx3 Fev Chrna4 Gnb3 Nfkb1 Creb1 Ret Ddc En1 Nkx2-2 Gata3 Nr3c1 Ascl1 Gata2 Lmx1b Il6 Sp1 Hes1 Hes5 Rora Maoa C4b C4a Ctcf Ar Rest Ppargc1a Tnf Ep300 Il10 Ryr2 Deaf1 Scn5a Ece1 ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260810%WP240%MUS MUSCULUS Alanine and aspartate metabolism Got2 Gpt Pcx Abat Ass1 Carns1 Asl Aspa Agxt Dars1 Gad1 Gad2 Crat Adsl Got1 GPCRS ORPHAN%WIKIPATHWAYS_20260810%WP1398%MUS MUSCULUS GPCRs orphan Gpr137b Adgrf5 Gpr137c Gpr165 Slc52a2 Gpr161 Adgrf2 Gpr180 Gpr107 Gpr137 Gpr4 Gpr179 Gpr155 Gphr Tpra1 Gpr108 Gpr31 Wls GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260810%WP157%MUS MUSCULUS Glycolysis and gluconeogenesis Hk1 Got1 Got2 Pdhx Pck1 Gpi Eno3 Eno2 Mpc1 Mpc2 Pgam2 Slc2a2 Pcx Pgam1 Slc2a5 Tpi1 Pdhb Gapdh Pkm Ldhc Slc2a1 Fbp1 Dld Slc2a3 Fbp2 Slc2a4 Ldhal6b Pklr Gapdhs Aldob Aldoc Aldoa Pfkl EG433182 Pgk1 Pgk2 Pfkm Pdha1 Pfkp Pdha2 Mdh1 Mdh2 G6pc1 Ldha Hk2 Ldhb Gck Hk3 Dlat EICOSANOID METABOLISM VIA LIPOXYGENASES LOX %WIKIPATHWAYS_20260810%WP4348%MUS MUSCULUS Eicosanoid metabolism via lipoxygenases LOX Cyp4a12a Cyp4f14 Cyp4a12b Cyp4f3 Cyp4a10 Ptgr2 Ptgr1 Acox1 Acox2 Hpgd Ehhadh Acox3 Acaa1a Dpep2 Mgst3 Mgst2 Ephx2 Alox12 Alox5 Dpep1 Lta4h Alox15 Ggt5 Ggt1 Ltc4s Gpx1 Gpx4 POLYOL PATHWAY%WIKIPATHWAYS_20260810%WP1265%MUS MUSCULUS Polyol pathway Aldob Sord Khk Akr1b1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260810%WP273%MUS MUSCULUS Ovarian infertility Gdf9 Nr5a1 Ncor1 Nrip1 Smad3 Smpd1 Prlr Cdkn1b Cebpb Esr2 Dazl Cdk4 Cyp19a1 Ptger2 Fshr Ccnd2 Gja4 Zp3 Inha Zp2 Syne2 Egr1 Tbp Bmpr1b Mlh1 Lhcgr Dmc1 Msh5 Vdr Pgr Atm CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260810%WP163%MUS MUSCULUS Cytoplasmic ribosomal proteins Rpsa Rpl38 Rps27a Rpl8 Rpl39 Rps10 Rpl9 Rps11 Rpl6 Rps12 Rpl7 Rps13 Rpl31 Rpl32 Rpl34 Rpl36a Rps3a1 Rps7 Rps8 Rps5 Rpl37a Rps6 Rplp2 Rpl24 Rpl26 Rpl27 Rpl28 Rpl29 Rps6ka3 Rpl21 Rplp0 Rpl22 Rplp1 Rps6ka2 Rpl13a Rpl18a Rpl13 Rpl15 Rpl17 Rpl18 Rpl19 Rpl10 Rpl11 Rps6kb2 Rpl12 Rps3 Rps2 Rpl10a Rpl7a Rps25 Rps26 Rps4x Rps27 Rps28 Rps29 Rpl27a Rps20 Rps21 Rps23 Rps24 Rpl41 Rpl35a Fau Rpl23a Rps6ka1 Rpl4 Rps14 Rps15 Rps16 Rpl3 Rps17 Rps18 Rpl30 Rps15a Rps19 Rpl35 Rpl36 Rpl37 KENNEDY PATHWAY%WIKIPATHWAYS_20260810%WP1771%MUS MUSCULUS Kennedy pathway Ptdss1 Ptdss2 Pisd Cept1 Chka Chkb Pemt Etnk2 Etnk1 Chpt1 Pcyt1b Pcyt1a Sgpl1 Pcyt2 FAS PATHWAY AND STRESS INDUCTION OF HSP REGULATION%WIKIPATHWAYS_20260810%WP571%MUS MUSCULUS FAS pathway and stress induction of HSP regulation Faf1 Ripk2 Prkdc Fasl Cflar Pak2 Bcl2 Lmnb1 Ptpn13 Lmnb2 Mapkapk3 Casp6 Sptan1 Jun Il1a Dffb Pak1 Casp8 Hspb1 Parp1 Fadd Mapkapk2 Mapk8 Map2k4 Rb1 Map3k7 Map3k1 Casp9 Casp3 Lmna Daxx Arhgdib Tnf Apaf1 Casp7 Fas Dffa TNF ALPHA NF KB SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP246%MUS MUSCULUS TNF alpha NF kB signaling pathway Map3k14 Rpl8 Rps11 Rpl6 Rps13 Mcm7 Src Mcm5 Hsp90aa1 Nfkb1 Rack1 Rela Tab2 Akt1 Skp1 Ppp2ca Rps6kb1 Ptpn11 Btrc Prkcz Nfkbia Faf1 Ripk2 Rel Cflar Pias3 Chuk Nkiras1 Flna Nkiras2 Cdc37 Map3k8 Nlrp4e Fbl Unc5cl Tnfrsf11a Akt2 Dpf2 Azi2 Ppp1r13l Polr1b Polr1c Polr1a Cav1 Gab1 Rnf216 Cul1 Usp2 Polr1g Polr1d Fbxw11 Casp8ap2 Csnk2a2 Ywhah Polr1e Txlna Csnk2a1 Tank Hsp90ab1 Mark2 Gtf2i Actl6a Map3k2 Smarce1 Tnf Tifa Cdc34 Csnk2b Traip Nfkbiz Papola Gsk3b Glg1 Ripk3 Cradd G3bp2 Dcaf7 Sumo1 Cops3 Nfkbib Capn3 Casp7 Kpna6 Mcc Kpna3 Eif4a3 Dap Crebbp Bcl3 Tab3 Tab1 Ccar2 Traf4 Pfdn2 Kcnq1 Traf5 Birc3 Birc2 Tnfrsf8 Ywhag Nr2c2 Ube2i Psmd12 Traf3 Ddx3x Traf6 Ywhae Smarcb1 Ikbke Ywhab Tbk1 Psmd13 Rasal2 Nfkb2 Akap8 Hdac6 Psmb5 Peg3 Bcl7a Casp8 Relb Cyld Ptk2 Fkbp5 Ywhaz Tradd Tnip2 Tnip1 Hspb1 Psmc2 Traf2 Psmc1 Fadd Psmc3 Polr2h Pdcd2 Nsmaf Map2k5 Bag4 Ripk1 Zfand5 Commd1 Trpc4ap Traf1 Rps6ka5 Psmd7 Map3k1 Psmd6 Nfkbie Fancd2 Psmd3 Stat1 Elp1 Casp2 Psmd1 Ktn1 Usp11 Smarcc2 Pebp1 Kpna2 Rnf25 Iqgap2 Tnfaip3 Lrpprc Mtif2 Hdac2 Pkn1 Hdac1 Alpl Prkaca Smarca4 Tnfrsf1b Tnfrsf1a Casp3 Pml Rpl4 Smarcc1 Ikbkb Rpl30 Ikbkg Map3k3 GPCRS OTHER%WIKIPATHWAYS_20260810%WP41%MUS MUSCULUS GPCRs other Or13a18 Or13a17 Gpr132 Or7a42 Or7a41 Or7a40 Or2ag2b Mtnr1b Vmn2r32 Vmn1r65 Vmn1r62 Vmn1r63 Gpr39 Htr1d Or2y1b Gpr34 V1ra8 Or13a28 Or13a27 Gpr143 Adgre5 Vmn1r58 Or2v1 Vmn1r56 Vmn1r53 Vmn1r54 Vmn1r51 Vmn1r52 Gpr146 Vmn1r50 Or3a1c Mc4r Or1e17 Or1d2 Or1e16 S1pr1 Pth2r S1pr2 S1pr5 Trhr2 Or51a39 Adgrf4 Vmn1r48 Vmn1r49 Vmn1r46 Or2w1 Vmn1r47 Gpr37l1 Irx6 Vmn1r44 Cysltr1 Vmn1r45 Vmn1r42 Vmn1r43 Ackr1 Vmn1r40 Cnr1 Vmn1r41 Or1f19 Or1j21 Mrgprh Or2a57 Oprk1 Vmn1r171 Vmn1r172 Or1m1 Gabbr1 Fzd1 Fzd2 Fzd5 Fzd7 Fzd9 Htr1a Vipr1 Smo Gpr165 Or8g20 Ghsr Or1e1f Gpr162 Prokr1 Adgrg1 Ednra Or8c9 Vmn2r104 Rrh Or1a1b Or1ad8 Or3a1 Or1e35 Or1e34 Vmn1r148 Oprl1 Adrb2 Adrb1 Vmn1r29 Vmn1r25 Or8g19 Or4b1d Or7e178 Or8d1 Sstr5 Or8u8 Or1e23 Or5g26 Vmn2r107 Oprm1 Tacr3 Or4c58 Or51a5 Calcr Casr Vmn1r15 Or1p1 Vmn1r13 Or1x2 Vmn1r14 Vmn1r11 Or2a7 Or6a2 Tas1r1 Vmn1r10 Or2z2 Ccr10 Or9s13 Or10p22 Gpr88 Gpr84 Gpr83 Drd1 Celsr3 Drd2 Or6z7 Celsr1 Or7a37 Drd5 Celsr2 Xcr1 Or6b9 Or13p10 Or2b6 Or1a1 Or7e165 Adora1 Adora3 Ltb4r2 Or2n1e Or2t1 Tmigd3 Grm1 Or51a10 Or1j1 ESTROGEN SIGNALING%WIKIPATHWAYS_20260810%WP1244%MUS MUSCULUS Estrogen signaling Mnat1 Src Hdac6 Elk1 Nfkb1 Creb1 Polr2h Mapk14 Mapk9 Mapk1 Grb2 Hras Akt1 Sos1 Sp1 Sin3a Hdac2 Hdac4 Pik3ca Braf Hdac1 Hdac3 Hdac5 Taf13 Taf12 Map2k1 Hdac7 Hdac8 Bcl2 Ak6 Chuk Gtf2a2 Gtf2b Gtf2f2 Gtf2e1 Gtf2e2 Prkaca Shc2 Ccnh Polr2c Jun Polr2a Polr2b Taf9 Polr2g Polr2e Ccnd1 Polr2f Polr2k Polr2i Ncor1 Polr2j Gnas Gtf2h2 Gtf2h4 Gtf2h1 Gtf2h3 Gngt1 Ercc2 Gper1 Esr1 Ercc3 Gnb1 Taf7 Cdk7 Taf6 Taf5 Tbp Ilk Fos Ep300 Ikbkb Brca1 Ikbkg Crebbp OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260810%WP1248%MUS MUSCULUS Oxidative phosphorylation Ndufa2 Atp5f1e Atp5f1d Ndufa5 Gzmb Atp5pb Ndufa7 Atp5pd Ndufa6 Ndufa9 Ndufa8 Atp5pf Ndufb10 mt-Atp8 Atp5po Ndufb2 Ndufb6 Ndufb5 Ndufb8 mt-Nd4l Ndufb7 Ndufb9 Atp5mf Atp5me Ndufv2 Dmac2l Atp5mg Ndufv1 Atp5f1b Ndufv3 Atp5f1a mt-Nd4 mt-Nd5 mt-Nd6 Ndufc1 Ndufc2 mt-Nd1 mt-Nd2 mt-Nd3 Ndufa11 Ndufa10 Ndufs1 Ndufs3 Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Coxfa4l2 Atp5mc1 Atp5mc3 Atp5mc2 Atp6ap2 Atp6ap1 Coxfa4 ATP6 Ndufa3 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260810%WP4350%MUS MUSCULUS Omega 3 omega 6 fatty acid synthesis Pla2g4b Fads1 Acot1 Pla2g5 Acot2 Elovl2 Pla2g6 Elovl5 Acsl1 Acox1 Pla2g4a Acsl3 Acsl4 Acox3 Fads2 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260810%WP300%MUS MUSCULUS Histone modifications Ehmt1 Hdac1 Hdac2 Ehmt2 Hat1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260810%WP523%MUS MUSCULUS Regulation of actin cytoskeleton Pxn Dock1 Pak1 Itga1 Nckap1 Mapk1 Vav1 Mapk3 Egfr Pik3r1 Crk Pik3r2 Sos1 Pik3cg Fgf13 Kras Raf1 Pik3cb Pik3cd Pik3ca Braf Fgf1 Fgfr1 Map2k2 Map2k1 Pak2 Mapk4 Rras Rac3 Rhoa Rac1 Pak6 Egf Fgf4 Fgf5 Apc Vcl Ins1 Ptk2 Ins2 Cdc42 Mapk6 Fgf3 Fgf6 Ppp1r12a Fgf7 Fgf9 Actb Nras Myl3 Gna13 Pip4k2b Arhgef1 Ezr Pip4k2c Was Arhgef7 Fgf8 Arhgef6 Arhgef4 F2r Iqgap1 Bdkrb2 Pak3 Bdkrb1 Myh10 Chrm1 Chrm3 Fgf10 Diaph1 Cfl1 Chrm2 Cfl2 Chrm5 Chrm4 Pdgfrb Pdgfra Pdgfa Myl1 Rras2 Pdgfb Limk1 Slc9a1 Actg1 Pfn1 Rdx Pip4k2a Pik3c2b Msn Fgf18 Pik3c2a Pik3c2g Fgf2 Ssh3 Ssh2 Fgfr4 Ssh1 Fgfr2 Mylk Vil1 Cyfip2 Arpc5 Cd14 Gng12 Fgf16 F2 Fgf17 Fgf14 Fgf15 Brk1 Fgf12 Pik3c3 Fgf11 Enah Mras Rac2 Baiap2 Git1 Diaph3 Apc2 Fgf20 Fgf23 Fn1 Fgf21 Fgf22 Actn1 Fgfr3 Pik3r5 Rassf7 Sos2 Pik3r3 Pik3r4 Gna12 Bcar1 Fgd1 Csk Pak5 Pak4 Tmsb4x Arhgap35 Wasf2 Gsn Wasf1 Mos Pip5kl1 Abi2 Pip5k1c Rock2 Pip5k1b Rock1 Pip5k1a STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP55%MUS MUSCULUS Steroid biosynthesis Hsd3b2 Hsd3b1 Hsd17b1 Hsd17b2 F13b Hsd17b7 Hsd17b3 Hsd3b3 Hsd17b4 Cyp17a1 Hsd3b6 Hsd3b5 Hsd3b4 ERBB SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP1261%MUS MUSCULUS ErbB signaling pathway Plcg1 Erbb2 Erbb4 Map2k7 Map2k1 Ereg Akt3 Abl1 Tgfa Cblc Araf Nrg2 Shc2 Hbegf Nrg1 Src Jun Areg Btc Nrg4 Nrg3 Elk1 Ptk2 Myc Gab1 Cdkn1b Stat5a Eif4ebp1 Mapk8 Pik3r5 Mapk1 Bad Egfr Grb2 Hras Pak4 Crk Sos1 Erbb3 Gsk3b Mtor Prkca Nck1 Cdkn1a Egf Camk2a OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260810%WP1274%MUS MUSCULUS Oxidation by cytochrome P450 Cyp4f3 Cyb5r4 Cyb5r3 Cyb5r2 Cyp2w1 Cyb5r1 Cyp2u1 Cyp2s1 Cyp4f39 Cyp39a1 Cyp2f2 Cyp1b1 Cyp51a1 Cyp7b1 Cyp4x1 Cyp26b1 Cyp2r1 Cyp4v3 Cyb5a Cyp26c1 Cyb5b Cyp2e1 Cyp19a1 Cyp46a1 Cyp27a1 Por Cyp11b1 Cyp21a1 Cyp20a1 Cyp27b1 Cyp26a1 Cyp1a1 Cyp11b2 Cyp4b1 Cyp8b1 Cyp24a1 Cyp1a2 Cyp7a1 Cyp17a1 Cyp11a1 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260810%WP1263%MUS MUSCULUS Mitochondrial gene expression Ppargc1a Ppp3ca Tfb1m Tfb2m Camk4 Nrf1 Hcfc1 Gabpa Esrra Myef2 Ppargc1b Mterf1a Gabpb2 Sp1 Mterf3 Tfam Pprc1 Polrmt Creb1 GPCRS PEPTIDE%WIKIPATHWAYS_20260810%WP234%MUS MUSCULUS GPCRs peptide Mc4r C5ar1 C3ar1 Bdkrb2 Bdkrb1 Ghsr Ednra Cckar Ednrb Cxcr2 Npy1r Oprk1 Cxcr3 Gnrhr Npy5r Ntsr2 Ntsr1 Trhr Oprl1 Brs3 Fpr-s1 Mc2r Oprd1 Ccr9 Cxcr4 Cxcr5 Ccr8 Cxcr6 Sstr5 Ccr6 Ccr5 Ccr4 Ccr3 Ccr2 Oprm1 Galr2 Tacr3 Galr3 Cckbr Galr1 Npy4r Agtr2 Cx3cr1 Avpr2 Sstr4 Sstr3 Sstr2 Mc1r Sstr1 Avpr1b Mc5r Tacr1 Avpr1a Ccr10 Tacr2 Fpr1 Nmbr Tshr Fshr Agtr1a Agtr1b Ccr1 Oxtr Npy2r Npy6r Grpr Mc3r Ccr1l1 Lhcgr OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260810%WP412%MUS MUSCULUS Oxidative stress response Gsr Cat Ugt1a1 Maoa Nfkb1 Mapk14 Cyp1a1 Gclc Hmox1 Mt1 Mapk10 Txn2 Mgst1 Fos Nqo1 Nfix Sp1 Sod3 Cyba Txnrd1 Sod2 Gabpb1 Sod1 Junb Gpx1 Txnrd2 Gstt2 Gpx3 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260810%WP4820%MUS MUSCULUS GDNF RET signaling axis Ift25 Bmp4 Lhx1 Foxc2 Gdnf Ret Sox11 Fat4 Gfra1 Ctnnb1 Gli3 Robo2 Pax2 Gata3 Foxc1 Agtr2 Grem1 Eya1 Sox17 Ift27 Sall1 Slit2 Spry1 LUNG FIBROSIS%WIKIPATHWAYS_20260810%WP3632%MUS MUSCULUS Lung fibrosis Ccl5 Smad7 Eln Il13 Il12b Ccn2 Dsp Tgfa Edn1 Atp11a Mmp2 Parn Sftpa1 Fam13a Csf2 Nfe2l2 Csf3 Mecp2 Mt2 Ccl11 Hgf Elmod2 Dpp9 Sftpc Ccl4 Ccl3 Ccl2 Cma1 Muc5b Cxcl2 Stn1 Cysltr2 Timp1 Rtel1 Il1b Fgf7 Ptx3 Cxcl15 Tert Il6 Pdgfa Pdgfb Igf1 Fgf2 Fgf1 Calca Ccr3 Mmp9 Ccr2 Spp1 Cebpb Bmp7 Il4 Il5 Plau Tnf Hmox1 Skil Grem1 Tgfb1 Egf FATTY ACID BETA OXIDATION STREAMLINED %WIKIPATHWAYS_20260810%WP3588%MUS MUSCULUS Fatty acid beta oxidation streamlined Hadha Fabp1 Acadl Eci1 Acadm Decr1 Cpt2 Acads Acadvl Echs1 Cpt1a Acsl5 Slc25a20 Acsl6 Hadh Hadhb Fabp4 Slc27a1 Acat1 Fabp2 Fabp3 Fabp7 Cd36 Slc27a5 Slc27a4 Acsl1 Slc27a3 Slc27a2 Cpt1b Slc27a6 Acsl3 Acsl4 ELECTRON TRANSPORT CHAIN%WIKIPATHWAYS_20260810%WP295%MUS MUSCULUS Electron transport chain Ucp3 mt-Nd4 mt-Nd5 mt-Nd6 Ndufc1 Ndufc2 mt-Nd1 mt-Nd2 mt-Nd3 Ndufa10 Ndufs1 Ndufs3 Ndufs2 Ndufs5 Ndufs4 Ndufs7 Ndufs6 Ndufs8 Cox5b Atp5mc3 Atp5mc2 Coxfa4 Slc25a4 ATP6 mt-Co1 Ndufa3 Ndufa2 Atp5f1e Atp5f1d Ndufa5 mt-Co2 Atp5pb Ndufa7 Atp5pd Ndufa6 Ndufa9 Ndufa8 Atp5pf Ndufb10 mt-Atp8 Atp5po Ndufb2 Ndufb6 Ndufb5 mt-Nd4l Ndufb7 Ndufb9 Atp5mf Atp5me Ndufv2 Dmac2l Atp5mg Ndufv1 Atp5f1b Ndufv3 Atp5f1a Sdhd Sdhc Sdhb Sdha Cox7a2l Cox6a1 Cox6a2 Uqcrfs1 Sco1 Uqcrq Atp5f1c Cox8a Cox6b1 Surf1 Cox15 Uqcrb Cox17 mt-Co3 mt-Cytb Uqcrh Ndufab1 Ndufa12 Cox7b Slc25a27 Cox4i1 Slc25a14 Cox6c Ndufa1 Cox7a1 Cox7a2 Ucp2 Cox5a Ndufb4 Uqcrc2 Ndufb3 Uqcrc1 Atp5if1 Uqcr10 Uqcr11 Slc25a5 Ucp1 FOCAL ADHESION PI3K AKT MTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP2841%MUS MUSCULUS Focal adhesion PI3K Akt mTOR signaling pathway Akt3 Ppp2cb Irs1 Irs2 Rps6 Hgf Met Hsp90aa1 Jak3 Foxo3 Jak2 Jak1 Eif4e Egfr Ifna1 Rps6kb2 Pik3r1 Pik3r2 Sos1 Mtor Rps6kb1 Pik3cg Fgf13 Kras Pik3cb Pik3cd Pik3ca Map2k2 Map2k1 Kdr Slc2a1 Slc2a3 Cdc37 Akt2 Mlst8 Ppp2r5c Hsp90ab1 Ppp2r5e Itgb6 Egf Nos3 Nos2 Tsc2 Lama1 Csf3 Vegfa Ins1 Gh Ins2 Irs4 Irs3 Prlr Fgf8 Hif1a Igf1 Fgf18 Fgf2 Ghr Epas1 Slc2a4 Acaca Foxo1 Ppp2r3a Ppp2r2d Col2a1 Ppp2r2c Eif4b Ppp2r2b Prkaa1 Prkaa2 Rab11b Fn1 Phlpp1 Il2ra Phlpp2 Eif4ebp1 Il2rb Ppp2r3d Fgfr3 Il2 Ppp2r3c Ulk1 Thbs2 Vtn Atf4 Osm Thbs4 Ppargc1a Igf1r Ngfr Gng10 Lamb2 Pdgfc Pdgfd Mtcp1 Lamb1 Pik3ip1 Col1a2 Elavl1 Tbc1d1 Col3a1 Gngt2 Col1a1 Lpar6 Lpar5 Ppp2r1b Lama5 Gng11 Il2rg Pelo Gng13 Il4ra Gng14 Rptor Lamc1 Ifnab Lamc2 Thbs1 Prl Thbs3 Osmr Srebf1 Gys1 Gys2 Ifnb1 Hif3a Ifna4 Ifna5 Ifna6 Ifna7 Ifna2 Kit Ifna9 Cab39 Col11a1 Col11a2 Hsp90b1 Ppp2r5d Ppp2r5b Ppp2r5a Foxa1 Strada Vegfd Rab8a Epo Tnc Comp Csf3r Rab2a Eif4e1b Tnn Tnr Tnxb Col5a2 Lipe Col5a3 Col5a1 Pgf Reln Lama2 Lama3 Lama4 Csf1 Creb3l3 Mapk1 Itga7 Chad Creb3l4 Mapk3 Il3ra Itga8 Creb3l1 Itga5 Itga6 Tcl1 Itga9 Akt1 Crtc2 Csf1r Atf6b Itga4 Itga2 Ppp2ca Itga10 Itga11 Insr Akt1s1 Col4a1 Col4a2 Col4a6 Stk11 Ibsp Gnb2 Gnb4 Cab39l Efna4 Raf1 Efna1 Efna2 Flt1 Ddit4 Efna3 Flt4 Tsc1 Eif4e2 Fgfr1 Fgf1 Pfkfb4 Pfkfb3 Ppp2r1a Pfkfb2 Rheb Pfkfb1 Pdpk1 Nos1 Itgae Angpt1 Lpar4 Lpar3 Itgal Angpt2 Lpar2 Lpar1 Angpt4 Creb3 Itgad Itgb8 Itgb7 Creb5 Ngf Epha2 Ifna13 Ifna14 Itga2b Gngt1 Ifna11 Itgb5 Il7r Ifnar1 Gnb1 Epor Gng3 Ifnar2 Gng2 Gng5 Gng4 Lamb3 Efna5 Gng7 Gng8 Tcl1b4 Tcl1b1 Rab10 Col6a2 Rab14 Lamc3 Tek Gsk3b Itgav Cdkn1a Itgb4 Itgb3 Fgf4 Atf2 Itga3 Col4a4 Ptk2 Il6ra Gnb3 Creb1 Cdkn1b Fgf3 Fgf6 Fgf7 Fgf9 Nras Casp9 Grb2 Bad Hras F2r Itgax Chrm1 Fgf10 Itgam Chrm2 Mdm2 Pdgfrb Pdgfra Pdgfa Vegfc Pdgfb Vegfb Pik3c2b Pik3c2a Slc2a2 Pik3c2g Itgb2 Fgfr4 Fgfr2 Creb3l2 Vwf Gng12 Fgf16 Fgf17 Fgf14 Fgf15 Itgb1 Fgf12 Spp1 Fgf11 Fgf20 Fgf21 Fgf22 Pik3r5 Pik3r4 Pten Kitlg Ikbkb Ikbkg CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260810%WP4346%MUS MUSCULUS Cholesterol metabolism with Bloch and Kandutsch Russell pathways Fdps Mvk Idi2 Fads1 Sqle Ebp Elovl4 Nsdhl Dhcr24 Dhcr7 Srebf2 Hmgcr Idi1 Cyp51a1 Nr1h3 Cyp46a1 Cyp27a1 Acat1 Nr1h2 Hmgcs1 Scd1 Acot1 Acot2 Elovl2 Elovl3 Elovl5 Acsl1 Fasn Ch25h Scd2 Fdft1 Acsl3 Ggps1 Abcg1 Acsl4 Sc5d Abca1 Lbr Acat2 Soat2 Soat1 Hmgcs2 Cyp7a1 Fads2 Hsd17b7 Lss Tm7sf2 Mylip Srebf1 Pmvk Mvd Msmo1 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260810%WP456%MUS MUSCULUS GPCRs class B secretin like Pth2r Ghrhr Gipr Adgrg2 Gcgr Adgre1 Adgrl2 Vipr2 Sctr Vipr1 Adgrl3 Adgrl4 Pth1r Adgre5 Adgrl1 Glp2r Calcr Adcyap1r1 Calcrl Glp1r Crhr2 Crhr1 MIR 1 IN CARDIAC DEVELOPMENT%WIKIPATHWAYS_20260810%WP608%MUS MUSCULUS miR 1 in cardiac development Irx5 Kcnd2 Hand2 INSULIN SIGNALING%WIKIPATHWAYS_20260810%WP65%MUS MUSCULUS Insulin signaling Map3k14 Map2k7 Cblc Socs1 Socs3 Irs1 Map4k1 Rapgef1 Lipe Rps6ka3 Foxo3 Rps6ka2 Mapk9 Mapk8 Mapk1 Map3k7 Mapk3 Eif4e Rps6kb2 Pik3r1 Akt1 Crk Pik3r2 Sos1 Insr Prkcb Cbl Mtor Rps6kb1 Prkca Ptpn11 Pik3cg Prkcz Raf1 Pik3cb Stxbp1 Pik3cd Pik3ca Tsc1 Stxbp3 Map2k2 Map2k1 Rheb Pdpk1 Slc2a1 Shc2 Jun Mapk4 Map3k8 Stxbp2 Akt2 Prkcq Gab1 Prkch Prkci Prkcd Sgk1 Map3k2 Rac1 Gsk3b Fos Mapk11 Tsc2 Shc1 Map3k9 Elk1 Map3k5 Map2k6 Irs4 Trib3 Cyth3 Mapk7 Irs3 Grb14 Grb10 Map3k6 Mapk6 Mapk14 Stxbp4 Map2k5 Gyg1 Kif5b Cblb Map2k4 Sorbs1 Rps6ka5 Map3k1 Shc3 Mapk13 Flot2 Flot1 Map4k5 Grb2 Map4k4 Map4k3 Rab4a Hras Map3k4 Xbp1 Tbc1d4 Srf Ehd1 Map4k2 Ehd2 Snap25 Snap23 Arf1 Rhoj Ptprf Rhoq Cap1 Rrad Inpp4a Vamp2 Rps6ka4 Rps6ka6 Mink1 Sgk3 Sgk2 Arf6 Pik3c2a Myo1c Pik3c2g Ptpn1 Stx4 Rps6ka1 Arhgap33 Inppl1 Ppp1cc Mapk12 Sh2b2 Map2k3 Map3k10 Map3k11 Slc2a4 Map3k12 Map3k13 Foxo1 Pfkl Pik3c3 Enpp1 Pfkm Rac2 Kif3a Prkaa1 Prkaa2 Eif4ebp1 Sos2 Pik3r3 Pik3r4 Igf1r Pten Egr1 Mapk10 Ikbkb Map3k3 Gys1 Gys2 HYPERTROPHY MODEL%WIKIPATHWAYS_20260810%WP202%MUS MUSCULUS Hypertrophy model Mstn Eif4ebp1 Eif4e Ifng Hbegf Dusp14 Il18 Il1a Jund Wdr1 Ankrd1 Zeb1 Vegfa Ifrd1 Il1r1 Ccn1 Nr4a3 Atf3 Myog Adam10 SIGNAL TRANSDUCTION OF S1P RECEPTOR%WIKIPATHWAYS_20260810%WP57%MUS MUSCULUS Signal transduction of S1P receptor Mapk6 Gnai3 Pik3c2g S1pr1 Mapk1 S1pr2 S1pr5 Mapk3 Mapk12 Akt3 Sphk2 Sphk1 Akt1 Akt2 Smpd2 Plcb3 Racgap1 Asah2 Mapk7 Gnai2 Gnai1 S1pr3 METAPATHWAY BIOTRANSFORMATION%WIKIPATHWAYS_20260810%WP1251%MUS MUSCULUS Metapathway biotransformation Sult6b1 Nat8l Inmt Ugt1a2 Naa40 Ugt2a2 Gsto1 Ugt2a3 Gsto2 Nat10 Ugt1a5 Nat14 Cyp4f3 Nnmt Ugt1a1 Hs3st3a1 Chst1 Akr1b1 Sult2a1 Chst3 Chst2 Chst5 Chst4 Chst7 Chst9 Ugt1a10 Naa30 Chst8 Gstp1 Gstz1 Cyp2w1 Hs3st4 Hs3st1 Cyp2u1 Hs3st2 Gsta3 Cyp2s1 Gsta4 Cyp4f39 Cyp39a1 Hs3st5 Cyp2f2 Gsta2 Cyp1b1 Hs3st6 Naa20 Cyp51a1 Cyp7b1 Akr1d1 Cyp4x1 Kcnab1 Kcnab2 Cyp2r1 Gpx5 Kcnab3 Cyp4v3 Glyat Sult1e1 Gal3st1 Cyp26c1 Fmo1 Cyp46a1 Fmo3 Cyp27a1 Fmo2 Fmo5 Cyp11b1 Hs6st3 Baat Hs6st2 Cyp21a1 Cyp20a1 Fmo4 Cyp1a1 Hs6st1 Cyp11b2 Akr1b10 Gal3st3 Gal3st2 Gss Sult2b1 Sult1a1 Cyp2e1 Cyp27b1 Cyp4b1 Cyp8b1 Mgst1 Cyp24a1 Cyp1a2 Cyp7a1 Gpx2 Gpx4 Gpx3 Gsr Cyp26b1 Cyp26a1 Gpx1 Cyp11a1 Chst11 Chst10 Mgst3 Akr7a2 Mgst2 Gal3st4 Chst12 Ephx2 Chst13 Chst14 Gstk1 Cyp19a1 Comt Naa80 Ndst1 Ndst2 Sult1c2 Ndst3 Ndst4 Sult4a1 Sult1b1 Ugt1a6 Ugt1a9 Hs3st3b1 Gstm5 Gsta1 Gstm4 Gstm1 Gstcd Gstm7 Hs2st1 Tpmt Hnmt Naa50 Gstt2 Nat8 Gstt1 Nat2 Cyp17a1 Ephx1 Akr1a1 Nat9 IL 9 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP10%MUS MUSCULUS IL 9 signaling pathway Stat5a Jak1 Mapk1 Map2k2 Stat5b Map2k1 Mapk3 Kat5 Stat3 Stat1 Grb2 Pik3r1 Akt1 Shc1 Vcp Tyk2 Il9 Socs3 Il9r Irs1 Irs2 Il2rg Ptpn11 Jak3 MACROPHAGE MARKERS%WIKIPATHWAYS_20260810%WP2271%MUS MUSCULUS Macrophage markers Cd74 Cd52 Lyz2 Cd163 Cd83 Rac2 Cd68 F3 Cd14 Cd86 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260810%WP441%MUS MUSCULUS Matrix metalloproteinases Bsg Mmp20 Mmp21 Mmp11 Mmp12 Mmp7 Mmp14 Mmp15 Mmp16 Mmp17 Mmp3 Mmp19 Timp2 Mmp13 Mmp2 Mmp8 Timp4 Tcf20 Mmp10 Mmp9 Timp1 Timp3 Mmp1a Tnf Mmp23 Mmp24 Mmp25 Mmp27 Mmp28 CHEMOKINE SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP2292%MUS MUSCULUS Chemokine signaling pathway Ccl5 Akt3 Pxn Pak1 Rap1a Rap1b Plcb1 Crkl Nfkb1 Jak3 Foxo3 Jak2 Mapk1 Vav1 Mapk3 Rela Pik3r1 Akt1 Crk Pik3r2 Sos1 Prkcb Pik3cg Gnb2 Gnb4 Kras Cxcr2 Prkcz Raf1 Pik3cb Cxcr3 Pik3cd Lyn Pik3ca Nfkbia Braf Ptk2b Stat5b Map2k1 Stat3 Plcb4 Ccr9 Chuk Cxcr4 Cxcr5 Ccr8 Cxcr6 Shc2 Ccr6 Ccr5 Ccr4 Tiam1 Ccr3 Tiam2 Ccr2 Ncf1 Pard3 Cxcr1 Prkx Rasgrp2 Akt2 Shc4 Cxcl12 Cx3cr1 Cxcl10 Ppbp Grk1 Grk2 Gngt1 Grk5 Grk4 Grk6 Elmo1 Gnb1 Prkcd Ccl21a Gng3 Gnb5 Hck Cxcl13 Gng2 Cxcl14 Gng5 Itk Gng4 Plcb2 Rhoa Adcy3 Gng7 Adcy4 Gng8 Ccr1 Adcy1 Rac1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Vav3 Ccr1l1 Adcy9 Gsk3b Ccl27a Prkacb Vav2 Fgr Gsk3a Xcl1 Nfkbib Ccl19 Ccl17 Dock2 Ccl9 Ccl8 Ccl12 Cxcl9 Ccl7 Ccl6 Arrb2 Arrb1 Ccl1 Cxcl1 Pf4 Cxcl5 Prex1 Cx3cl1 Ccl28 Ccl26 Ccl24 Ccl25 Ccl22 Shc1 Ccl11 Ptk2 Ccl4 Ccl3 Ccl2 Gnb3 Cdc42 Cxcl2 Cxcl15 Shc3 Nras Stat1 Grb2 Was Hras Wasl Gng12 Prkaca Rac2 Plcb3 Gnai2 Gnai1 Gnai3 Ccr10 Cxcl16 Pik3r5 Sos2 Pik3r3 Bcar1 Gng10 Csk Gngt2 Xcr1 Gng11 Gng13 Rock2 Gng14 Rock1 Ikbkb Ikbkg Stat2 Ccl20 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260810%WP3675%MUS MUSCULUS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling Igf1 Mstn Smad2 Trim63 Jkamp Igfbp2 Igfbp5 Igfbp4 Foxo1 Igfbp1 Pdk1 Igfbp7 Itgb1 Igfbp6 Irs1 Tnfsf9 Prkab1 Acvr2b Smad3 Nfkb1 Igfbp3 Tnfrsf1a Ppargc1a Igf1r Pld1 Tnf Akt1 Pten Ilk Mtor Rps6kb1 GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260810%WP327%MUS MUSCULUS GPCRs class C metabotropic glutamate pheromone Grm8 Grm3 Gabbr1 Gabbr2 Gprc5b Casr Gprc5a Gprc5d Gprc5c Grm2 Grm5 Grm1 Grm4 Grm7 Grm6 PPAR SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP2316%MUS MUSCULUS PPAR signaling pathway Cyp4a12a Fabp1 Cyp4a12b Cyp4a10 Gk Lpl Acox1 Acox2 Ehhadh Gk2 Acox3 Acaa1a Aqp7 Dbi Angptl4 Cyp4a30b Scd3 Sorbs1 Cyp4a32 Nr1h3 Slc27a1 Olr1 Cyp27a1 Cyp4a31 Cyp4a29 Fabp2 Apoa1 Fabp3 Rxra Acaa1b Fabp7 Apoa2 Slc27a5 Apoa5 Slc27a4 Pltp Cyp4a14 Slc27a2 Ubc Cpt1b Fabp5 Slc27a6 Rxrg Fabp6 Scd4 Acsbg1 Acsbg2 Mmp1b Apoc3 Me1 Cpt1c Pck1 Pck2 Acadl Acadm Cpt2 Plin1 Pdpk1 Adipoq Cpt1a Scp2 Acsl5 Acsl6 Scd1 Ppard Ppara Pparg Ucp1 Rxrb Mmp1a Fabp4 Cd36 Acsl1 Ilk Scd2 Cyp8b1 Acsl3 Acsl4 Hmgcs2 Cyp7a1 Fads2 GPCRS ODORANT%WIKIPATHWAYS_20260810%WP1397%MUS MUSCULUS GPCRs odorant Gpr22 Gpr21 Or5j3 Gpr20 Tas2r113 Or3a10 Or7a40 Tas2r114 Tas2r129 Adgrd1 Ptgdr2 Gpr139 Gpr135 Or5p79 Gpr37 ADGRF3 Gpr33 Or2y1b Taar6 Gpr34 Gpr35 V1ra8 Taar9 Taar3 Tas2r120 Or5p80 Taar2 Taar5 Taar4 Tas2r124 Vmn1r53 Tas2r125 Vmn1r54 Gpr142 Vmn1r51 Gpr141 Vmn1r52 Opn1mw Gpr146 Mrgprx1 Taar7e Rho Or5t7 Or5t9 Or1e16 Gpr153 Tas2r106 Tas2r107 Gpr152 Gpr150 Adgrf1 Tas2r109 Adgrf4 Or8b8 Vmn1r48 Or5t17 Or5t15 Vmn1r46 Gpr3 Or8b3 Vmn1r47 Gpr157 Gpr37l1 Gpr158 Ackr5 Gpr156 Or5m5 Vmn1r45 Lgr4 Vmn1r42 Lgr5 Vmn1r43 Lgr6 Tas2r102 Or4b13 Mrgpre Tas2r104 Mrgprf Mrgprg Mrgprh Or1m1 Brs3 Gpr137b Adgrf5 Gpr137c Gpr165 Slc52a2 Gpr161 Adgrf2 Gpr180 Gpr107 Gpr137 Gpr4 Gpr179 Gpr155 Gphr Gpr162 Tpra1 Gpr108 Gpr31 Adgrg5 Wls Hcar1 Adgrg6 Adgrg7 Gpr160 Adgrg3 Mrgpra6 Tas2r39 Or5p52 Tas2r38 Gpr61 Oprl1 Gpr63 Mrgpra1 Or10d3 Mrgpra4 Gpr176 Gpr173 Gpr171 Or7e178 Or8g17 Vmn2r1 Cmklr1 Cmklr2 Or4c3d Or5g26 Or8u9 Or5g25 Gpr75 Or5ap2 Adgra2 Gpr183 Tas1r2 Or5g9 Or10n1 Or10d1b Gpr101 Tas1r3 Or5p76 Or2a7 Or10h28 Gpr87 Tas1r1 Or5p4 Gpr85 Tas2r135 Tas2r134 Or9s13 Gpr82 Or10p22 Or7d11 Gpr88 Tas2r136 Gpr84 Or5ar1 Gpr83 Or5b21 Gpr19 Or5p58 Or5p57 Or2c1 Mrgprb8 Gpr12 Mrgprb1 Tas2r143 Mrgprb2 Or6b9 Adgra3 Mrgprb3 Or2b6 Mrgprb4 Mrgprb5 Tas2r117 Tas2r116 Opn1sw Or8a1b Gpr26 Or5h19 Gpr25 Or5h17 Or5h18 Gpr27 Or1j1 FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260810%WP1269%MUS MUSCULUS Fatty acid beta oxidation Hadha Acadl Eci1 Tpi1 Acadm Decr1 Cpt2 Acads Acadvl Echs1 Cpt1a Acsl5 Dld Gk Slc25a20 Acsl6 Hadh Lpl Pnpla2 Gk2 Lipc Lipe Crat Lipf Acss2 Hadhb Chkb Acat1 Acsl1 Cpt1b Acsl3 Acsl4 Gcdh Gpd2 SPINAL CORD INJURY%WIKIPATHWAYS_20260810%WP2432%MUS MUSCULUS Spinal cord injury Pla2g5 Pla2g6 Mapk1 Mapk3 Icam1 E2f5 Pla2g2a Sox9 Ppp3ca Col4a1 Prkca Nr4a1 Aqp4 Pdyn Zfp36 Omg Pirb Plxna2 Mag Mmp12 Anxa1 Prb1a Klk8 Rtn4 Selp Nos1 Bcan Mbp Efnb2 Ptpra Cspg4 Nox4 Il1a Btg2 Bdnf Ptprz1 Ccr2 Slit1 C5 Ccnd1 Slit3 Rhoc Rgma Rhob Vcan Sema6a Cxcl10 Ltb4r Tnfsf13b Gap43 Arg1 Epha4 Ltb Cdk1 Ntn1 Tnfsf13 Tacr1 Cd47 Ncan Rtn4r Fcgr2b Gfap Xylt1 Rhoa Grin1 Fkbp1a Tnf Fos Tgfb1 Slit2 Gdnf Cxcl1 Nos2 Gja1 Ccng1 Myc Ccl2 Tlr4 Cxcl2 Vim Il1b Cdk4 Trp53 Cdk2 Il6 Chst11 Mmp9 Il1r1 Col2a1 Gadd45a Il2 Il4 Rb1 Acan Ngfr Ifng Casp3 Egr1 Rock2 E2f1 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260810%WP683%MUS MUSCULUS Leptin and adiponectin Prkab1 Adipor2 Lep Adipor1 Prkag1 Lepr Adipoq Cpt1a Prkaa1 Acaca MAPK CASCADE%WIKIPATHWAYS_20260810%WP251%MUS MUSCULUS Mapk cascade Braf Map2k2 Map2k1 Mapk12 Map2k3 Mbp Araf Map3k12 Jun Elk1 Map2k6 Plcb3 Mapk14 Mapk1 Map2k4 Rras Map3k1 Mapk3 Nras Rasa3 Map2 Map3k2 Sipa1 Hras Mapk10 Kras Map3k3 Raf1 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260810%WP222%MUS MUSCULUS Cytokines and inflammatory response Cxcl1 Il13 Il12b Il1a Cd4 Csf2 Csf3 Csf1 Il2 Il1b Il4 Il5 Ifng Ifna1 Il11 Tnf H2-Eb1 Il15 Il12a Il3 Il7 Cxcl3 Il6 Pdgfa Il10 Tgfb1 Ifnb1 EGFR1 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP572%MUS MUSCULUS EGFR1 signaling pathway Map3k14 Wnk1 Map2k7 Cblc Araf Rasa1 Src Pxn Socs1 Pak1 Socs3 Crkl Rps6ka3 Jak2 Jak1 Rps6ka2 Mapk8 Mapk1 Gab2 Dnm1 Vav1 Mapk3 Egfr Pld1 Pik3r1 Akt1 Crk Pik3r2 Sos1 Ptpn6 Prkcb Cbl Itch Prkca Ptpn11 Pik3cg Kras Prkcz Raf1 Pik3cb Stxbp1 Pik3cd Pik3ca Ptk2b Map2k2 Stat5b Map2k1 Stat3 Jun Prkd1 Smad3 Cav2 Cav1 Gab1 Prkci Map3k2 Rac1 Tgif1 Vav3 Appl1 Atf1 Fos Vav2 Sh2d3c Elk4 Eps8 Ralb Krt7 Plcg2 Eps15 Nck1 Dok2 Ap2a1 Egf Snca Krt8 Grb7 Camk2a Plcg1 Pitpna Rab5a Pld2 Smad2 Errfi1 Usp6nl Ptk6 Ralgds Rfxank Arf4 Hip1 Sh3bgrl Shoc2 Ptprr Ndufa13 Ywhab H3f4 Shc1 Nck2 Gja1 Asap1 Plec Sh3gl3 Sh3kbp1 Elk1 Epn1 Elf3 Klf11 Sh3gl2 Plscr1 Ceacam1 Ralbp1 Myc Tnip1 Prkar1a Htt Abi1 Ptpn5 Mapk7 Appl2 Cdc42 Grb14 Creb1 Dusp1 Grb10 Hat1 Rgs16 Ptpn12 Mapk14 Map2k5 Krt18 Ripk1 Snrpd2 Krt17 Cblb Mcf2 Rps6ka5 Reps1 Map3k1 Spry2 Nras Eps15l1 Casp9 Reps2 Stat1 Grb2 Ctnnd1 Tnk2 Pkn2 Zpr1 Hras Map3k4 Pebp1 Sp1 Wasl Sin3a Pik3c2b Hdac1 Rps6ka1 Inppl1 Map2k3 Foxo1 Jund Eef1a1 Git1 Stat5a Cebpb Cebpa Sos2 Pik3r3 Mta2 Bcar1 Csk Rbbp7 Stat2 Map3k3 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260810%WP578%MUS MUSCULUS Leptin insulin signaling overlap Jak2 Pik3r3 Stat3 Pdpk1 Lepr Dgkz Akt1 Socs1 Socs3 Irs1 Insr Ins1 Irs2 Lep Irs4 Pik3cg Irs3 Socs2 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260810%WP4344%MUS MUSCULUS Sphingolipid metabolism overview Plpp3 Plpp1 Sgpl1 Smpd1 Cers6 Cers4 Cers3 Asah1 Cers1 Sgms1 Sgms2 Ugt8 Sptlc1 Cerk Sptlc2 Degs2 Degs1 Gdf1 Sphk2 Sphk1 Kdsr Sgpp2 Ugcg Sgpp1 Cers2 MRNA PROCESSING%WIKIPATHWAYS_20260810%WP310%MUS MUSCULUS mRNA processing Virma Htatsf1 Tmem163 Oasl2 Snrnp40 Eftud2 Snrpf Snrpe Snrpg Snrpb Snrpa Snrpc Snrpn Alyref Ppp1r14b Ggcx G3bp1 Smn1 Elmod3 Mrpl23 Tia1 Fus Cnot4 Ybx1 Lsm2 Lsm4 Lsm1 Son Lsm7 Lsm8 Safb2 Eral1 Synj2 Aco1 Sbno1 Hnrnpab Ilkap Mrpl11 Rnpep Clasrp Srsf1 Eif4e Ptbp3 Tert Ptbp2 Ddx19b Srsf9 Srsf7 Ddx19a Srsf6 Srsf5 Adam5 Srsf4 Dis3 Srsf3 Spen Srsf2 Myef2 Ankar Srek1 Eif3b Tsn Snrnp35 Hnrnpa3 Pcolce Sart3 Puf60 Wbp4 U2af1 Ppil4 Mrm3 Hnrnpa1 Hnrnpa0 Zfp385a U2af2 Bicc1 Cstf2t Ciz1 Ssb Celf6 Celf5 Celf4 Celf3 Celf2 Eif2d Pabpn1 Pskh1 Ro60 Sfswap Mak16 Park7 Ppm1g Dicer1 Rngtt Smc1a Enox1 Enox2 Rnps1 Ltv1 Rbfox1 Rbfox2 Prpf40a Prpf40b Cdk9 Cirbp Uhmk1 Cdc40 Ddx39a Hnrnpll Prmt1 Esrp2 Pcbp2 Imp3 Pcbp1 Ddx39b Pcbp4 Esrp1 Pcbp3 Imp4 Xrn2 Alkbh8 Hnrnpr Dhx8 Rbms1 Rbm11 Rbms3 Rbm10 Rbms2 Rbm12 Fxr1 Oas1g Fxr2 Oas1b Slc25a4 Oas1a Dhx38 Dnd1 Elavl4 Elavl2 Adarb2 Elavl3 Tial1 Aimp1 Pum2 Pum3 Sugp1 Sugp2 Pum1 Srpk1 Zrsr2 Hnrnpc Hnrnpd Hnrnpf Hnrnpk Hnrnpl Srpk2 Hnrnpm Adad1 Cstf1 Nudt21 Auh Sltm Prmt2 Dhx16 Cstf2 Cstf3 Dhx15 Rsrc2 Rnasel Akap1 Slc6a8 Csde1 Rbpms2 Srsf11 Srsf12 Srsf10 Srrm1 Boll Prpf4b Slu7 Tlr5 Raver1 Nol8 Mbnl1 Rae1 Npm1 Bclaf1 Ergic2 Tardbp Znf346 Rnaset2b Hnrnph2 Hnrnph1 Prpf4 Prpf6 Rbmxl2 Rbmxl1 Pspc1 Prpf3 Zmat4 Zmat2 Rdm1 Ppie Tarbp2 Syncrip Zbp1 Rbmx2 Matr3 Mrps28 Rbm4b Prpf8 D1Pas1 Brwd1 Papolg Ppp1r8 Nono Papolb Nop9 Clk1 Pabpc1 Clk2 Pabpc2 Clk3 Clk4 Ralyl Cpsf4 Cpsf7 Srp14 Cpsf1 Cpsf2 Eif4h Cpsf3 Ddx1 Tdrd7 Ddx4 Ddx5 Srp19 Ddx6 Slirp Rbm33 Dnajc8 Dis3l2 Rbm34 Eif3g Taf15 Rbm26 Eif4g3 Ppargc1a Rbm3 Rbm4 Celf1 Nufip1 Rbm25 Rbm28 Sfpq Lingo1 Elavl1 Ddx56 Rbm7 Rbm5 Rbm6 Txnl4a Adar Naa38 Rbm22 Rbm14 Eif4a2 Rbm17 Rbm19 Oas2 Rbm18 Ankrd33b Oas3 Ddx41 Nifk Poldip3 Rpp14 Trim21 Nxf1 Ncbp2 Rbmy Cd2bp2 Cyp4f3 Rbmx Nxf7 Tnrc6c Snrpd1 Tra2b Acin1 Rbm42 Rbm41 Rbm43 Snrpd3 Rbm45 Rbm39 Rbm38 Ttc14 Znf622 Eif4e3 Ddx25 Naa12 Rnaseh2a Ddx24 Ddx21 Ddx20 Ttc39a Dhx9 Hnrnpu Eif4e2 Dazl Abcb4 Brca1 Ppargc1b Ncl Grsf1 Ewsr1 Rps14 Rpl37 Rpl38 Rpl8 Rpl39 Rpl9 Rps11 Rpl7 Rps13 Rpl32 Rps7 Eif4g2 Rps6 Rpl26 Sf3a3 Rpl22 Qki Rbpms Rpl19 Rpl11 Rpl12 Rps4x Rps27 Rps28 Rps29 Rps20 Rps23 Rps24 Fbl Papola Eif4a3 Ddx3x Traf6 Eif2ak2 Secisbp2 Csad Polr2a Polr2g Col4a3 Snrpd2 Afg3l2 Afg3l1 Phf5a Igf2bp3 Rbm15b Igf2bp1 Znf830 U2surp Lsm11 Vmn1r26 Trmt2a Clp1 Snrpb2 Trmt1l Snu13 Fdx2 Raly Cfb Dcaf1 Rad21 Snrpa1 Bard1 Mettl3 Ptbp1 Cpeb1 Cpeb3 Cpeb4 Rpl39l Rnpc3 Mcts2 Wdr55 Scaf8 Nelfe Tmed10 Zfp638 Rbm47 Srp68 Pabpc4 Pabpc5 Pabpc6 Stau1 Rbm12b1 Rbm12b2 Slbp Zfp740 Srp9 Rbm8a Tut1 Nip7 Gatc Sf3a1 Sf3a2 Dazap1 Exosc9 Exosc8 Exosc5 Exosc4 Exosc7 Sf3b1 Sf3b2 Sf3b3 Sf3b4 Dnajc17 Sf3b5 Sf3b6 Akap17b Srp54 Adat1 Atxn1 Fmr1 Rnpepl1 Msi1 Msi2 Alyref2 Rbm31y Hnrnpa2b1 Supt5h Rps9 Rnmt Snrnp70 Ilf3 Hnrnpdl Spop Zcrb1 LIPIDS MEASURED IN LIVER METASTASIS FROM BREAST CANCER%WIKIPATHWAYS_20260810%WP4627%MUS MUSCULUS Lipids measured in liver metastasis from breast cancer Lrat HYPOXIA DEPENDENT DIFFERENTIATION OF MYOBLASTS%WIKIPATHWAYS_20260810%WP5025%MUS MUSCULUS Hypoxia dependent differentiation of myoblasts Mapk14 Myh1 Myf6 Myf5 Bhlhe40 Vegfa Notch1 Hif1a Cdkn1a Hif1an Myog Egln1 Cdkn1b WNT SIGNALING PATHWAY AND PLURIPOTENCY%WIKIPATHWAYS_20260810%WP723%MUS MUSCULUS Wnt signaling pathway and pluripotency Ppp2cb Ptpa Mapk9 Ppp2r2a Hnf1b Zbtb33 Ctnnb1 Nkd2 Map3k7 Sox2 Ppm1j Wnt5a Ppp2ca Prkcb Axin1 Axin2 Prkca Prkcz Tcf7l1 Nanog Nlk Mmp7 Wnt3a Ppp2r1a Dvl1 Dvl2 Dvl3 Wnt2 Wnt1 Wnt4 Wnt3 Fzd1 Jun Fzd2 Fzd5 Fzd4 Ccnd1 Fzd7 Fzd6 Fzd9 Fzd8 Prkd1 Pafah1b1 Prkcq Prkcg Prkch Prkci Prkcd Tcf4 Prkce Ldlr Fbxw2 Ppp2r5c Fosl1 Rhoa Ccnd2 Ccnd3 Ctbp1 Ctbp2 Ppp2r5e Plau Cd44 Gsk3b Csnk1e Lef1 Lrp6 Ep300 Lrp5 Nkd1 Crebbp Wnt7a Apc Frat1 Nfya Foxd3 Myc Ctnnd1 Pou5f1 Trp53 Hnf1a Ppard Ppp2r2d Racgap1 Ppp2r2c Ppp2r2b Wnt11 Wnt6 Wnt7b Wnt5b Wnt9b Wnt10a Wnt10b Fzd3 Wnt2b Mapk10 Wnt16 Ppp2r1b FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP5128%MUS MUSCULUS Fibrin complement receptor 3 signaling pathway Pik3ca Itgb2 Fgb Fga Rel Tyrobp Il12b Chuk Traf6 Nos2 Fgg Cd14 Plg Src Ticam2 Irak4 Ticam1 Irak2 Irak1 Myd88 Cxcl10 Irf3 Ccl2 Nfkb1 Tlr4 Tirap Tlr3 Plat Syk Cblb Rassf5 Rhoa Lbp Rela Ly96 Fcer1g Tnf Akt1 Cxcl3 Itgam Il6 Ikbkb Ikbkg Ifnb1 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260810%WP454%MUS MUSCULUS Osteoclast signaling Ifnar1 Itgb3 Trpv5 Ctsk Tnfsf11 Atp6v1g1 Tnfrsf11b Gpr68 Acp5 Spp1 Tnfrsf11a Pdgfb Slc9a1 Ifnb1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260810%WP166%MUS MUSCULUS Apoptosis modulation by HSP70 Ripk1 Map3k1 Tnfrsf1a Casp9 Casp3 Casp2 Casp6 Apaf1 Hspa1a Aifm1 Mapk10 Casp8 Casp7 Fas Nfkb1 Fadd Bid IL 4 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP93%MUS MUSCULUS IL 4 signaling pathway Plcg1 Atf2 Rasa1 Shc1 Src Socs1 Socs3 Irs1 Elk1 Irs2 Ets1 Ptk2 Nfkb1 Jak3 Jak2 Mapk14 Jak1 Mapk1 Mapk3 Rela Stat1 Bad Grb2 Pik3r1 Akt1 Pik3r2 Sos1 Tyk2 Ptpn6 Spi1 Prkd3 Stam Pawr Cbl Socs5 Bcl2l1 Il13ra1 Inpp5d Rps6kb1 Grk3 Ptpn11 Fes Fyn Prkcz Pik3cd Pik3ca Hmga1 Stat6 Cxcr4 Ncf1 Stat5a Prkci Prkcd Il4 Il2rg Lck Il4ra Ep300 Mapk11 Dok2 Crebbp MONOAMINE GPCRS%WIKIPATHWAYS_20260810%WP570%MUS MUSCULUS Monoamine GPCRs Htr6 Htr7 Hrh2 Htr2c Htr2a Htr2b Adrb2 Drd3 Adrb1 Drd4 Adra1b Adrb3 Adra1a Htr1a Adra1d Htr1f Htr1b Htr1d Htr5b Htr5a Drd1 Drd2 Drd5 Chrm1 Chrm3 Chrm2 Chrm5 Chrm4 Adra2a Adra2c Adra2b Htr4 Hrh1 IL 5 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP151%MUS MUSCULUS IL 5 signaling pathway Pim1 Atf2 Shc1 Socs1 Pla2g4a Elk1 Ywhaz Rapgef1 Crkl Nfkb1 Foxo3 Cdkn1b Jak2 Mapk14 Jak1 Mapk9 Syk Mapk1 Ctnnb1 Vav1 Mapk3 Stat1 Grb2 Icam1 Alox5ap Pik3r1 Hras Akt1 Pik3r2 Alox5 Ptpn6 Itgam Prkcb Cbl Ptpn11 Pik3cg Kras Hcls1 Raf1 Bax Lyn Nfkbia Ptk2b Itgb2 Map2k2 Rps6ka1 Stat5b Stat3 Sh2b2 Rap1gap Shc2 Csf2rb Jun Sox4 Sdcbp Dnm2 Btk Unc119 Stat5a Il2rb Prkcd Hck Il5 Ccnd3 Rac1 Gsk3b Gsk3a Il5ra CHOLESTEROL BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP103%MUS MUSCULUS Cholesterol biosynthesis Fdps Mvk Sqle Nsdhl Hmgcs1 Dhcr7 Hmgcr Idi1 Fdft1 Sc5d Lss Pmvk Cyp51a1 Mvd Msmo1 TCA CYCLE%WIKIPATHWAYS_20260810%WP434%MUS MUSCULUS TCA cycle Pcx Pdhb Dld Pdk1 Cs Idh3g Suclg1 Pdha1 Suclg2 Pdha2 Pdk4 Mdh1 Ogdh Mdh2 Pdk3 Sucla2 Pdk2 Fh Idh2 Dlat Idh3a Dlst Idh3b Pdp1 Pdp2 Aco2 Sdhd Sdhc Sdhb Sdha Pdhx FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260810%WP33%MUS MUSCULUS Fatty acid omega oxidation Adh4 Cyp2e1 Aldh1a1 Adh1 Aldh2 Adh7 Cyp1a2 Cyp1a1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP1249%MUS MUSCULUS EPO receptor signaling Map2k2 Stat5b Map2k1 Stat3 Cish Rasa1 Shc1 Src Epo Pdk1 Socs1 Irs1 Irs2 Jak2 Stat5a Epor Mapk1 Mapk3 Ptpru Stat1 Ptprc Grb2 Akt1 Sos1 Pik3cg Raf1 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260810%WP238%MUS MUSCULUS Osteoblast signaling Col1a1 Pth1r Pth Pdgfrb Pdgfra Bglap2 Slc17a2 Tnfsf11 Tnfrsf11b Fgf23 ESC PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260810%WP339%MUS MUSCULUS ESC pluripotency pathways Smad7 Akt3 Araf Acvr1 Jak1 Mapk1 Ctnnb1 Egfr Wnt5a Akt1 Pik3r2 Sos1 Axin1 Mtor Ptpn11 Fgf13 Raf1 Pik3cd Braf Fgf1 Fgfr1 Map2k2 Wnt3a Map2k1 Dvl1 Stat3 Dvl2 Dvl3 Wnt2 Wnt1 Wnt4 Wnt3 Fzd1 Jun Mapk4 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Akt2 Fzd8 Smad4 Gab1 Actr2 Gsk3b Nog Fos Lrp6 Lrp5 Selenop Egf Lif Smad1 Bmp4 Wnt7a Smad9 Fgf4 Fgf5 Smad5 Apc Smad6 Elk1 Map2k6 Myc Mapk7 Lifr Mapk6 Fgf3 Map2k5 Fgf6 Fgf7 Fgf9 Grb2 Hras Fgf8 Fgf10 Mdm2 Pdgfrb Pdgfra Pdgfa Pdgfb Fgf18 Fgf2 Eras Hnf1a Fgfr4 Fgfr2 Mapk12 Map2k3 Fgf16 Fgf17 Fgf14 Fgf15 Fgf12 Fgf11 Il6st Fgf20 Fgf23 Bmpr1a Fgf21 Fgf22 Fgfr3 Wnt11 Wnt6 Wnt7b Wnt5b Wnt9b Wnt10a Wnt10b Pten Fzd3 Bmpr1b Wnt2b Wnt16 Bmpr2 B CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP274%MUS MUSCULUS B cell receptor signaling pathway Rasa1 Rps6 Map4k1 Rapgef1 Crkl Mapk8 Syk Mapk1 Gab2 Ctnnb1 Map3k7 Vav1 Mapk3 Rela Pik3r1 Akt1 Crk Ppp3ca Pik3r2 Sos1 Ptpn6 Prkcb Cbl Inpp5d Rps6kb1 Ptpn11 Pik3cg Fyn Raf1 Lyn Nfkbia Braf Ptk2b Hdac5 Map2k2 Map2k1 Ccne1 Rel Hdac7 Stat3 Bcl2 Pdpk1 Chuk Jun Mapk4 Btk Prkd1 Pdk2 Prkcq Gab1 Prkcd Prkce Cdk7 Hck Fcgr2b Itk Rhoa Ccnd2 Gtf2i Ptprc Ccnd3 Actr2 Cd72 Stap1 Sla2 Chst15 Cd81 Gsk3b Arpc1b Dok1 Actr3 Vav2 Dok3 Rasgrp3 Gsk3a Cd79a Blk Cd79b Casp7 Plcg2 Bcl10 Pik3ap1 Nck1 Ppp3cb Arpc3 Arpc2 Bcl6 Plcg1 Cd19 Arpc4 Itpr2 Itpr1 Ccna2 Rap2a Bcl2l11 Dapp1 Bank1 Cd22 Atp2b4 Plekha2 Plekha1 Card11 Atf2 Lat2 Shc1 Blnk Hnrnpk Lime1 Lcp2 Ppp3r1 Dusp4 Elk1 Ptpn18 Cd5 Dusp6 Ptk2 Sh3bp2 Cmtm3 Tec Nedd9 Creb1 Mapkapk2 Cr2 Mapk14 Cdk6 Cblb Cdk4 Casp9 Stat1 Pip4k2b Grb2 Pip4k2c Was Cdk2 Nfatc1 Nfatc3 Hcls1 Nfatc2 Bax Pip4k2a Rps6ka1 Sh2b2 Arpc5 Foxo1 Zap70 Sos2 Rb1 Bcar1 Csk Lck Pip5k1c Pip5k1b Pip5k1a Ikbkb Ikbkg GPCRS NON ODORANT %WIKIPATHWAYS_20260810%WP1396%MUS MUSCULUS GPCRs non odorant Cckar Ednrb Cxcr2 Npy1r Cxcr3 Gnrhr Npy5r Grm3 Ntsr2 Ntsr1 Trhr Gabbr1 Mc2r Oprd1 Gabbr2 Ccr9 Cxcr4 Cxcr5 Ccr8 Cxcr6 Ccr6 Ccr4 Ccr3 Ccr2 Galr2 Cckbr Cxcr1 Galr1 Npy4r Agtr2 Cx3cr1 Avpr2 Sstr4 Sstr3 Sstr2 Mc1r Sstr1 Avpr1b Mc5r Tacr1 Avpr1a Tacr2 Fpr1 Nmbr Tshr Agtr1a Agtr1b Ccr1 Oxtr Npy2r Npy6r Grpr Mc3r Ccr1l1 Gprc5b Gprc5a Gprc5d Grm2 Grm5 Grm4 Grm7 Adgrb1 Grm6 Cysltr2 Grm8 Ghsr Prokr1 Adgrg1 Ednra Rrh Adrb2 Adrb1 Sstr5 Oprm1 Pth1r Tacr3 Calcr Casr Ccr10 Drd1 Celsr3 Drd2 Celsr1 Drd5 Celsr2 Xcr1 Lpar6 Lpar5 Adora1 Adora3 Ltb4r2 Tmigd3 Grm1 Tbxa2r Ptgdr Gpr132 Ptgfr Mtnr1b Htr1d Gpr143 Adgre5 Ptgir Mc4r S1pr1 Pth2r S1pr2 S1pr5 Gpr68 Cysltr1 Ackr1 Cnr1 Adra2a Adra2c Adra2b Htr4 Oprk1 Hrh1 Htr6 Htr7 Hrh2 Htr2c Htr2b Drd3 Drd4 Adra1b Adrb3 Adra1a Adra1d Htr1f Lpar4 Htr1b Htr5b Lpar3 Htr5a Fzd1 Fzd2 Lpar2 Fzd5 Lpar1 Fzd4 Fzd7 Fzd6 Fzd9 Fzd8 Ltb4r Gper1 Htr2a Htr1a Ghrhr Gipr Adgrg2 Gcgr Adgre1 Vipr2 Adgrl2 Vipr1 Sctr Adgrl3 Adgrl4 Adgrl1 Glp2r Calcrl Adcyap1r1 Glp1r Crhr2 Crhr1 Smo Adora2b Adora2a Gpr174 Rxfp3 Rxfp2 Rxfp1 Rxfp4 C5ar1 Tas2r16 C3ar1 Tas2r13 Tas2r137 Adgrb2 Adgrb3 Gpr18 Gpr15 Gpr17 Tas2r140 Npbwr1 Gpbar1 Nmur2 Nmur1 Tas2r4 F2r Ptger4 Bdkrb2 Tas2r7 Bdkrb1 Ptger3 Ptger1 Chrm1 Mchr1 Chrm3 Mtnr1a Chrm2 Rgr Chrm5 Taar1 Chrm4 Kiss1r Ptafr Npffr2 Gprc6a Gpr6 Npsr1 P2ry10 P2ry13 P2ry12 P2ry14 Mas1 Gpr50 F2rl1 Tas2r40 Tas2r41 F2rl2 F2rl3 Prokr2 Hcar2 Gpr65 C5ar2 Ffar3 Ffar4 Aplnr Ffar1 Ffar2 Hrh4 Hrh3 Opn4 Opn3 Ccrl2 Oxgr1 Opn5 Sucnr1 Gpr119 Tas2r119 Prlhr Tas2r110 Qrfpr Tas2r123 S1pr3 Adgre4 P2ry6 P2ry4 P2ry2 P2ry1 Hcrtr2 Hcrtr1 Ptger2 S1pr4 Fshr Tas2r105 Ackr3 Ackr2 Cnr2 Uts2r Mrgprd Fzd3 Tas2r103 Lhcgr MIRNAS AND TFS IN IPS CELL GENERATION%WIKIPATHWAYS_20260810%WP2375%MUS MUSCULUS miRNAs and TFs in iPS Cell Generation Sox2 Prpf4 Sf3a3 Ddx39b Snrpa Pou5f1 Phf5a MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260810%WP1560%MUS MUSCULUS MicroRNAs in cardiomyocyte hypertrophy Tab1 Map3k14 Map2k7 Edn1 Ikbke Nrg1 Map2k6 Mapk7 Nfkb1 Mapk14 Map2k5 Mapk8 Mapk1 Map2k4 Ctnnb1 Mapk3 Wnt5a Pik3r1 Akt1 Pla2g2a Pik3r2 Ppp3ca Gata4 Nppb Myef2 Prkcb Mtor Nfatc4 Pik3cg Hdac4 Raf1 Pik3cb Pik3cd Igf1 Pik3ca Fgf2 Hdac5 Map2k2 Wnt3a Map2k1 Hdac7 Dvl1 Stat3 Pdpk1 Fgfr2 Mylk Chuk Map2k3 Cish Fzd1 Mapk4 Fzd2 Calm1 Akt2 Il6st Cdk9 Cdk7 Pik3r3 Plcb2 Rhoa Igf1r Rac1 Tnf Eif2b5 Agt Rcan1 Hdac9 Gsk3b Mylk3 Prkg1 Nppa Ctf1 Lrp6 Rock2 Rock1 Ikbkb Ikbkg Lrp5 Tgfb1 Ppp3cb Camk2d Egf Lif HEDGEHOG SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP116%MUS MUSCULUS Hedgehog signaling pathway Cdk1 Ihh Gli3 Ccnb1 Gli1 Gli2 Rab23 Dhh Hhip Stk36 Shh Ptch1 Smo Ptch2 Sin3a Sap18 Sufu Dyrk1a Gas1 Igf2 Crebbp BMP SIGNALING PATHWAY IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260810%WP3663%MUS MUSCULUS BMP signaling pathway in eyelid development Smad1 Bmp4 Mapk9 Foxc2 Pitx2 Map3k1 Mapk3 Smad5 Fgfr2 Egfr Tgfa Sfrp1 Jun Fgf10 Notch1 Foxc1 Inhbb Shh Smad4 Dkk2 NA K ATPASE SRC SIGNALING%WIKIPATHWAYS_20260810%WP5051%MUS MUSCULUS Na K ATPase Src signaling Srms Atp1a1 Txk Atp1b1 Erbb2 Tesk2 Tnk1 Ptk6 Birc3 Styk1 Birc2 Akt3 Araf Shc1 Src Dock1 Pak1 Elk1 Rap1a Cav3 Rap1b Map2k6 Ptk2 Rapgef1 Met Crkl Mapk7 Mapk6 Map2k5 Mapk9 Mapk8 Mapk1 Ctnnb1 Vav1 Shc3 Casp9 Egfr Bad Grb2 Tnk2 Cyct Pik3r1 Hras Akt1 Apaf1 Crk Pik3r2 Sos1 Pak3 Mtor Pdgfrb Pdgfra Pik3cg Cycs Fyn Raf1 Pik3cb Pik3cd Flt1 Pik3ca Braf Map2k2 Map2k1 Pak2 Mapk12 Bcl2 Kdr Map2k3 Jun Mapk4 Ccnd1 Akt2 Rac2 Cav2 Cav1 Hck Pik3r5 Rac3 Pik3r4 Ccnd2 Igf1r Bcar1 Ccnd3 Casp3 Rac1 Pak5 Pak4 Pten Ilk Gsk3b Fgr Pak6 Blk Selenop Xiap FATTY ACID OXIDATION%WIKIPATHWAYS_20260810%WP2318%MUS MUSCULUS Fatty acid oxidation Acadm Mttp Cpt2 Slc25a29 Acads Acadvl Echs1 Acaa2 Cpt1a Hadh OXIDATIVE STRESS AND REDOX PATHWAY%WIKIPATHWAYS_20260810%WP4466%MUS MUSCULUS Oxidative stress and redox pathway Gsr Gsto1 Gsto2 Ncf4 Slco1a1 G6pd2 Grxcr2 Grxcr1 Slc6a5 Prdx3 Gstp2 Prdx4 Prdx5 Slc6a9 Nfe2l2 Hpgds Prdx1 Gstp1 Gpx8 Pgd Abcc5 Gstm3 Gstt3 Ptgs1 Foxp3 Ptgs2 Gsta3 Lap3 Gsta4 Ctla4 Gsta2 Slc7a11 Txn Slco2a1 Gstm6 Prdx6b Prdx6 Gpx5 S100a9 Gpx7 S100a8 Ggt7 Ggt6 Cybb Keap1 Ncf2 Gclc Alox5 Cbs Gclm Nrf1 Gss Ggt1 Sod3 Sod2 Prdx2 Sod1 Gpx1 Gls Ncf1 Slc1a5 Idh2 Mgst3 Mgst2 Gstk1 Slc1a2 Rac1 Cd44 Ggt5 Gsta1 Gstm5 Mgst1 Gstm4 Idh1 Gstm1 Anpep Abcc2 Gstm7 Cyba Txnrd1 Ggct Txnrd3 Gstm2 Gpx2 G6pdx Txnrd2 Gpx4 Gstt2 Gstt1 Gpx3 Oplah Gpx6 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260810%WP6%MUS MUSCULUS Integrin mediated cell adhesion Akt3 Araf Src Pxn Dock1 Pak1 Itga1 Rap1a Rap1b Rapgef1 Rho Mapk1 Itga7 Tns1 Itga8 Mylk2 Vasp Itga5 Itga6 Capn9 Itga9 Capn5 Akt1 Capn7 Crk Capn6 Pik3r2 Capn1 Sos1 Itga4 Capn2 Itga2 Git2 Itga10 Zyx Itga11 Capns1 Capn10 Capn11 Fyn Raf1 Braf Map2k2 Map2k1 Pdpk1 Pak2 Itgae Itgal Mapk4 Itgad Itgb8 Itgb7 Akt2 Cav2 Itga2b Cav1 Itgb5 Rac3 Rac1 Ilk Vav3 Itgav Itgb6 Vav2 Pak6 Capn3 Selenop Itgb4 Itgb3 Tln1 Vcl Shc1 Itga3 Cav3 Ptk2 Map2k6 Mapk7 Cdc42 Mapk6 Map2k5 Sorbs1 Shc3 Grb2 Arhgef7 Hras Itgax Pak3 Itgam Itgb2 Mapk12 Map2k3 Itgb1 Rac2 Actn1 Bcar1 Csk Pak4 Mapk10 Rock2 Rock1 PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260810%WP374%MUS MUSCULUS Prostaglandin synthesis and regulation S100a10 Ptgdr Ptgds Ptgfr Anxa1 Edn1 Tbxas1 Pla2g4a Hpgd Ptgis Ptgir Ptgs1 Ptgs2 Ptger2 Ptger4 Ptger3 Ptger1 Anxa8 Anxa6 S100a6 Scgb1a1 Ednra Hsd11b1 Prl Hsd11b2 Ednrb Anxa5 Cyp11a1 Anxa4 Anxa3 Anxa2 IL 3 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP373%MUS MUSCULUS IL 3 signaling pathway Id1 Src Pxn Pak1 Socs3 Rap1a Rapgef1 Crkl Nfkb1 Jak2 Jak1 Mapk9 Mapk8 Syk Mapk1 Gab2 Dnm1 Rack1 Vav1 Mapk3 Il3ra Rps6kb2 Pik3r1 Akt1 Crk Pik3r2 Sos1 Tyk2 Ppp2ca Ptpn6 Spi1 Prkcb Cbl Bcl2l1 Inpp5d Prkca Ptpn11 Fes Kras Fyn Raf1 Pik3cd Lyn Matk Pik3ca Fcer2a Gata1 Bmx Stat5b Birc5 Kcnip3 Map2k1 Stat3 Bcl2 Selp Cish Slc2a1 Csf2rb Gab1 Hck Rac1 Il3 Gsk3b Atf1 Gsk3a Socs2 Bcl2l11 Vcl Mmp2 Atf2 Ywhab Shc1 Chek1 Ptk2 Ywhaz Tec Hspb1 Mapk7 Cdc42 Creb1 Mapkapk2 Mapk14 Stat1 Grb2 Bad Rxra Hras Gata2 Bax Stat6 Rara Prkaca Foxo1 Mmp9 Mras Rac2 Stat5a Tnfrsf1b Lck ETHANOL METABOLISM RESULTING IN PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260810%WP4265%MUS MUSCULUS Ethanol metabolism resulting in production of ROS by CYP2E1 Prkcd Nfe2l2 Mapk8 Map2k2 Cyp2e1 Map2k1 Maff Sp1 Mafg Mafk T CELL RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP480%MUS MUSCULUS T cell receptor signaling pathway Txk Stk39 Abl1 Rasa1 Src Pxn Pak1 Rap1a Map4k1 Shb Rapgef1 Crkl Jak3 Syk Mapk1 Gab2 Ctnnb1 Vav1 Mapk3 Vasp Pik3r1 Akt1 Crk Pik3r2 Sos1 Git2 Ptpn6 Dtx1 Cbl Ptpn11 Cabin1 Fyn Lyn Braf Ptk2b Ripk2 Map2k2 Stat5b Map2k1 Hdac7 Sla Cish Prkd2 Sit1 Sh2d2a Lax1 Wipf1 Jun Fcrl5 Grap Pag1 Dnm2 Tubb5 Unc119 Fyb1 Homer3 Pstpip1 Rasgrp2 Cd8a Lat Ptprj Acp1 Dlg1 Ptprh Skap2 Skap1 Prkcq Tuba4a Evl Cd247 Cd3g Cd3e Ptpn3 Cd3d Cd2 Itk Dusp3 Def6 Muc1 Ptprc Trat1 Nfam1 Grap2 Khdrbs1 Ptpn22 Dbnl Sla2 Vav3 Fos Vav2 Sh2d3c Cd2ap Bcl10 Dock2 Nck1 Ppp3cb Crebbp Plcg1 Itpr1 Card11 Shc1 Lime1 Lcp2 Cd5 Ptk2 Sh3bp2 Nedd9 Ncl Abi1 Mapk7 Cdc42 Creb1 Ptpn12 Cblb Map3k1 Stat1 Grb2 Was Arhgef7 Arhgdib Arhgef6 Nfatc2 Cd4 Enah Rac2 Sh2b3 Zap70 Stat5a Cebpb Sos2 Wasf2 Lck OXYLIPINS PATHWAYS%WIKIPATHWAYS_20260810%WP5140%MUS MUSCULUS Oxylipins pathways Ptgds Fads1 Ephx2 Alox8 Alox12 Tbxas1 Cbr1 Alox5 Dpep1 Lta4h Hpgd Alox15 Hpgds Ptgis Ptges Ggt1 Ltc4s Fads2 Ptgs2 Gpx1 Prxl2b SEROTONIN RECEPTOR 2 AND STAT3 SIGNALING%WIKIPATHWAYS_20260810%WP2079%MUS MUSCULUS Serotonin receptor 2 and STAT3 signaling Gnaq Jak2 Htr2a Stat3 MISMATCH REPAIR%WIKIPATHWAYS_20260810%WP1257%MUS MUSCULUS Mismatch repair Mlh1 Msh6 Lig1 Msh2 Rfc1 Exo1 Pold1 Rpa1 Pcna IRON HOMEOSTASIS%WIKIPATHWAYS_20260810%WP1596%MUS MUSCULUS Iron homeostasis Hamp Tnf Il1a Slc40a1 Il6 Ftl1 Hamp2 Il6ra Tf Tfr2 Ireb2 Fth1 Hjv Hfe ID SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP512%MUS MUSCULUS ID signaling pathway Acvrl1 Id1 Smad1 Id2 Bmp6 Tcf12 Id4 Ccna2 Msc Tcf7l2 Psmd4 Smad5 Vegfa Irs1 Elk1 Nfkb1 Ctnnb1 Myf6 Rela Tert Cdk2 Id3 Hes1 Myog Flt1 Igf1 Bmp2 Ccne1 Myf5 Kdr Rbl2 Rbl1 Ngf Atf3 Myod1 Smad3 Smad4 Tcf3 Rb1 Igf1r Cd40lg Tgif1 Pax2 Bmpr2 Elk4 Lck Srebf1 Elk3 Egf Pax5 Pax8 REGULATION OF CARDIAC HYPERTROPHY BY MIR 208%WIKIPATHWAYS_20260810%WP1526%MUS MUSCULUS Regulation of cardiac hypertrophy by miR 208 Gata4 Mstn Med13 Gja5 Hopx Myh7 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP18%MUS MUSCULUS Heme biosynthesis Cpox Uros Urod Ppox Alad Alas1 Alas2 Hmbs Fech MIR 193A AND MVP IN COLON CANCER METASTASIS%WIKIPATHWAYS_20260810%WP3979%MUS MUSCULUS mir 193a and MVP in colon cancer metastasis G3bp1 Ccnd1 Mvp Caprin1 Ccnd2 Myc PDGFR ALPHA AND STMN1 COOPERATE TO EXACERBATE CYTOTOXIC EFFECTS OF VINBLASTINE%WIKIPATHWAYS_20260810%WP4398%MUS MUSCULUS PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine Stmn1 Pdgfra PENTOSE PHOSPHATE PATHWAY%WIKIPATHWAYS_20260810%WP63%MUS MUSCULUS Pentose phosphate pathway Pgd Rpia Rpe Taldo1 G6pdx Pgls Tkt GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260810%WP189%MUS MUSCULUS GPCRs class A rhodopsin like Cckar Ednrb Cxcr2 Npy1r Cxcr3 Npy5r Ntsr2 Ntsr1 Trhr Brs3 Gabbr1 Fpr-s1 Mc2r Oprd1 Ccr9 Cxcr4 Cxcr5 Ccr8 Ccr6 Ccr5 Ccr4 Ccr3 Ccr2 Galr2 Galr3 Cckbr Galr1 Npy4r Agtr2 Cx3cr1 Avpr2 Sstr4 Sstr3 Sstr2 Mc1r Sstr1 Avpr1b Mc5r Avpr1a Fpr1 Nmbr Tshr Agtr1a Agtr1b Ccr1 Oxtr Npy2r Npy6r Grpr Mc3r Ccr1l1 Or13j1 Or8b12c Or10d1 Or8b12i Or8c15 Or8c16 Or2d3b Or8d2b Or8d1b Tcp10b Or11h4 Fpr2 Or8b12 Or8b40 Or8b39 Or8b101 Or6e1 Or10j5 Gpr45 Or2ag2 Or2ag1 Or8g23 Or8g24 Or8g26 Or8g20 Or8g27 Or8c8 Or8g28 Or8g18 Or10d4b Or10d4c Or10d1c Or8g2b Or2ag19 Rrh Or8g32 Or8g34 Or8g35 Or8g36 Or8g37 Or6b6 Or2ag20 Oprl1 Or13c7d Gpr63 Adrb2 Or13c7 Adrb1 Or13c7b Or8g30 Oxt Or8g19 Or2d2 Or2d4 Or2d3 Or8g17 Or8g53 Sstr5 Or8g55 Cmklr1 Or13e8 Or8d23 Or8a1 Fpr-rs4 Oprm1 Fpr-rs3 Or8b4 Or2d36 Or10a4 Or10a5 Or10a2 Or10n1 Or6a2 Gpr87 Gpr83 Gpr19 Or5p57 Or2c1 Gpr12 Or6b9 Adora3 Opn1sw Or8a1b Tmigd3 Tbxa2r Gpr27 Ptgdr Ptgfr Or7a40 Or2ag2b Ptgdr2 Gpr37 Htr1d Gpr33 Gpr34 Gpr35 Ptgir Opn1mw Mc4r Rho Trhr2 Or8b8 Gpr3 Gpr37l1 Cysltr1 Cnr1 Adra2a Adra2c Adra2b Htr4 Oprk1 Hrh1 Htr6 Htr7 Hrh2 Htr2c Htr2b Drd3 Drd4 Adra1b Adrb3 Adra1a Adra1d Htr1f Htr1b Htr5b Htr5a Ltb4r Gper1 Htr2a Avp Htr1a Adora2b Adora2a C5ar1 C3ar1 Nmur1 F2r Ptger4 Bdkrb2 Bdkrb1 Ptger3 Ptger1 Chrm1 Chrm3 Mtnr1a Chrm2 Rgr Chrm4 Ptafr P2ry13 P2ry12 P2ry14 Mas1 Gpr50 F2rl1 F2rl2 F2rl3 Hcar2 Gpr65 Aplnr Opn4 Opn3 Ccrl2 Sucnr1 P2ry6 P2ry4 P2ry2 P2ry1 Ptger2 Fshr Ackr3 Ackr2 Cnr2 Lhcgr SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260810%WP2140%MUS MUSCULUS Serotonin and anxiety related events Htr2c Htr2a Htr1a Ppp3ca Fos Prkcb Plcd4 Nlgn1 Crhr1 Arc Crh Plek Grin2d APOPTOSIS%WIKIPATHWAYS_20260810%WP1254%MUS MUSCULUS Apoptosis Birc3 Bcl2l11 Birc2 Irf6 Traf3 Pmaip1 Trp73 Casp8 Tradd Myc Irf3 Traf2 Nfkb1 Fadd Bid Ripk1 Bak1 Map2k4 Traf1 Map3k1 Nfkbie Rela Casp9 Bad Casp2 Pik3r1 Akt1 Apaf1 Trp53 Mdm2 Bcl2l1 Bax Igf1 Nfkbia Birc5 Fasl Cflar Bcl2 Chuk Casp6 Jun Dffb Hells Hrk Prf1 Trp63 Igf2 Bok Bcl2l2 Tnfsf10 Bnip3l Tnfrsf1b Irf4 Irf1 Scaf11 Tnfrsf1a Tnfrsf10b Irf2 Igf1r Lta Casp3 Irf7 Irf5 Gzmc Tnf Mcl1 Tnfrsf21 Casp4 Tnfrsf25 Diablo Mapk10 Cradd Nfkbib Ikbkb Casp7 Fas Ikbkg Casp1 Dffa Xiap WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2872%MUS MUSCULUS White fat cell differentiation Stat5b Nr2f2 Rara Foxo1 Pparg Ins1 Klf15 Irf3 Creb1 Cebpd Cebpb Stat5a Cebpa Ddit3 Irf4 Tle3 Nr1h3 Ebf1 Wnt10b Klf4 Gata3 Nr3c1 Mecom Klf2 Ctnna1 Gata2 Klf5 Zfp423 Srebf1 Egr2 Tcf7l1 Rora CIRCULATING MONOCYTES AND CARDIAC MACROPHAGES IN DIASTOLIC DYSFUNCTION%WIKIPATHWAYS_20260810%WP4474%MUS MUSCULUS Circulating monocytes and cardiac macrophages in diastolic dysfunction Ccr2 Spp1 Il10 Ccl2 ESTROGEN METABOLISM%WIKIPATHWAYS_20260810%WP1264%MUS MUSCULUS Estrogen metabolism Sult1e1 Ugt1a2 Comt Ugt1a1 Cyp1a1 Ugt1a6 Ugt1a9 Gsta1 Nqo1 Gstm1 Cyp1a2 Sult1a1 Cyp1b1 TRANSCRIPTIONAL ACTIVATION BY NFE2L2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260810%WP1245%MUS MUSCULUS Transcriptional activation by Nfe2l2 in response to phytochemicals Cebpb Pik3ca Mapk8 Keap1 Gclc Hmox1 Gclm Nfe2l2 Aimp2 Nqo1 Prkca Gsta2 Ephb2 Maf FOCAL ADHESION%WIKIPATHWAYS_20260810%WP85%MUS MUSCULUS Focal adhesion Srms Txk Erbb2 Tesk2 Tnk1 Styk1 Col11a1 Akt3 Col11a2 Araf Src Vegfd Pxn Dock1 Tnc Pak1 Rap1a Rap1b Hgf Tnn Tnr Rapgef1 Tnxb Met Col5a2 Col5a3 Crkl Col5a1 Pgf Reln Lama2 Lama3 Lama4 Mapk9 Mapk8 Mapk1 Itga7 Chad Vav1 Itga8 Egfr Mylk2 Vasp Itga5 Itga6 Itga9 Pik3r1 Akt1 Crk Pik3r2 Capn1 Sos1 Itga4 Itga2 Itga10 Zyx Itga11 Col4a1 Col4a2 Col4a6 Ibsp Pik3cg Fyn Raf1 Pik3cb Pik3cd Flt1 Pik3ca Braf Map2k2 Map2k1 Bcl2 Pdpk1 Pak2 Itgae Itgal Jun Mapk4 Flna Ccnd1 Itgad Itgb8 Itgb7 Rhob Akt2 Cav2 Itga2b Cav1 Itgb5 Hck Rac3 Rhoa Lamb3 Ccnd2 Ccnd3 Rac1 Col6a2 Lamc3 Ilk Gsk3b Itgav Itgb6 Fgr Pak6 Blk Selenop Egf Itgb4 Ptk6 Itgb3 Birc3 Birc2 Tln1 Vcl Shc1 Itga3 Lama1 Vegfa Elk1 Cav3 Col4a4 Ptk2 Map2k6 Mapk7 Cdc42 Mapk6 Map2k5 Ppp1r12a Actb Shc3 Grb2 Bad Tnk2 Itgax Pak3 Itgam Diaph1 Pdgfrb Pdgfra Pdgfa Vegfc Pdgfb Vegfb Actg1 Igf1 Itgb2 Mapk12 Mylk Vwf Map2k3 Itgb1 Spp1 Rac2 Col2a1 Fn1 Actn1 Pik3r5 Thbs2 Vtn Pik3r4 Thbs4 Bcar1 Lamb2 Pdgfc Pdgfd Pak5 Lamb1 Pak4 Pten Col1a2 Col3a1 Col1a1 Lama5 Arhgap5 Myl6 Pelo Pip5k1c Parvb Rock2 Farp2 Rock1 Lamc1 Lamc2 Thbs1 Thbs3 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260810%WP396%MUS MUSCULUS ACE inhibitor pathway Bdkrb2 Agtr1a Agtr2 Ren1 Ren2 Ace Nos3 Kng1 Agt GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260810%WP4345%MUS MUSCULUS Glycerolipids and glycerophospholipids Ptdss1 Cdipt Ptdss2 Crls1 Pisd Chkb Pld1 Dgkz Pemt Pnpla2 Etnk1 Plpp1 Chpt1 Dgat2 Gpam Pcyt1a Dgat1 Pcyt2 Cds1 Gpat4 Pnpla3 Pla2g1b Agpat4 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260810%WP519%MUS MUSCULUS Proteasome degradation H2ax Psma3 Psma6 Psma5 Psme3 Psmd4 Psma2 Psma1 Psme2 Psme1 Psmd12 Psmd11 Psmd10 Ube2b Psmb10 Psmd13 Uchl4 Psmb4 Psmb7 Psmb6 Psmb5 Psmb1 Psmb3 Psmb2 Ube2d3 Ube2d1 Psma7 Psmc6 Psmc5 Psmc2 Rpn2 Psmc1 Psmc4 Psmc3 Rpn1 Uba7 Ubb Psmb9 Psmb8 H2az1 Psmd9 Uchl1 Psmd7 Psmd8 Psmd6 Psmd2 Psmd5 Psmd3 Ube2d2a Uba1 Hist1h2an H2-Q10 Ubc Ifng Psma4 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260810%WP567%MUS MUSCULUS Eukaryotic transcription initiation Taf13 Taf12 Ak6 Gtf2a2 Gtf2b Gtf2f2 Gtf2e1 Gtf2e2 Polr2c Mnat1 Ccnh Polr2a Polr2b Taf9 Polr2g Polr2e Polr2k Polr2i Polr2j Gtf2h2 Gtf2h4 Gtf2h1 Gtf2h3 Polr1b Polr1c Polr2h Ercc2 Polr1a Ercc3 Polr1d Taf7 Cdk7 Taf6 Taf5 Polr3d Polr3e Polr3b Tbp Polr3h Ilk Polr3k SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260810%WP2084%MUS MUSCULUS SREBF and miR33 in cholesterol and lipid homeostasis Sirt1 Ppara Med15 Sirt6 Ldlr Nr1h3 Mtor Ppargc1a Srebf2 Hmgcr Srebf1 TGF BETA RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP258%MUS MUSCULUS TGF beta receptor signaling pathway Smad7 Kat2b Tfdp2 Tfdp1 Ube2d3 Ets1 Ube2d1 Cdc25a Foxo3 Ppp2r2a Mapk8 Hspa8 Ctnnb1 Map3k7 Ube2d2a Pik3r1 E2f5 Pik3r2 Hnf4a Skp1 Stambpl1 Cdc27 Prkcb Vdr Cdc23 Dcp1a Axin1 Rbx1 Axin2 Stk11 Eid2 Hgs Nup153 Btrc Gipc1 Sdc2 Anapc5 Yap1 Snip1 Anapc4 Anapc1 Anapc2 Snx4 Dab2 Trap1 Snw1 Snx2 Snx1 Ccne1 Tgfb3 Dvl1 Anapc7 Cited1 Snx6 Cops5 Nup214 Sparc Pias1 Fnta Jun Cdc16 Xpo1 Foxg1 Foxo4 Anapc10 Pard3 Ccnd1 Smurf2 Stk11ip Hoxa9 Nfyb Prkar1b Ar Ctcf Nfyc Smad3 Strap Fzr1 Smad4 Ap2b1 Fosb Cav1 Prkar2a Esr1 Cul1 Cdk1 Prkcd Fkbp1a Tgif1 Cd44 Fos Lef1 Zeb2 Sumo1 Foxh1 Ep300 Junb Skil Eng Tgfb1 Camk2g Cdkn1a Tgfbr3 Camk2d Camk2b Crebbp Camk2a Acvrl1 Arrb2 Tab1 Smad2 Zfyve9 Runx2 Kpnb1 Ccnb2 Tgfbr2 Smad6 Atf2 Nfya Pias2 Trp73 Map2k6 Tgfb2 Myc Mapk14 Cdk6 Cdk4 Tgfbr1 Daxx Trp53 Cdk2 Sp1 Hdac1 Map2k3 Foxo1 Jund Zeb1 Rbl2 Rbl1 Atf3 Eif3i Ncoa1 Rb1 Mef2a Mef2c Rock1 Erbin E2f4 EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES%WIKIPATHWAYS_20260810%WP4349%MUS MUSCULUS Eicosanoid metabolism via cytochrome P450 monooxygenases Cyp2c38 Cyp2c39 Cyp2c37 Cyp4a12a Cyp2c23 Ephx2 Cyp4f14 Cyp2j5 Cyp2c54 Cyp4a12b Cyp2c55 Cyp4f3 Cyp2c40 Cyp4a10 Ppara Cyp2c29 AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260810%WP1262%MUS MUSCULUS Aflatoxin B1 metabolism Akr7a2 Gstm1 Cyp1a2 Gstt1 Ephx1 METHYLATION%WIKIPATHWAYS_20260810%WP1247%MUS MUSCULUS Methylation Mat2b Inmt Comt Nnmt Pnmt Tpmt Mat2a Hnmt Mat1a IL 1 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP37%MUS MUSCULUS IL 1 signaling pathway Plcg1 Nfkbia Tab1 Map3k14 Map2k1 Chuk Traf6 Il1a Irak4 Irak3 Il1r1 Irak2 Irak1 Myd88 Nfkb1 Mapk8 Il1b Mapk1 Map3k7 Mapk3 Rela Tab2 Il1rap Elp1 Peli1 Sqstm1 Tollip Akt1 Sirpa Il1r2 Capn1 Il1rn Capns1 Nfkbib Ptpn11 Casp1 Prkcz KIT RECEPTOR SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP407%MUS MUSCULUS Kit receptor signaling pathway Plcg1 Mitf Kit Abl1 Rasa1 Shc1 Src Socs1 Sh3kbp1 Plce1 Tec Crkl Grb10 Jak2 Mapk1 Cblb Vav1 Stat1 Bad Grb2 Pik3r1 Hras Akt1 Crk Pik3r2 Sos1 Ptpn6 Prkcb Cbl Socs5 Inpp5d Prkca Ptpn11 Pik3cg Fes Fyn Raf1 Lyn Matk Rps6ka1 Stat5b Map2k1 Stat3 Sh2b2 Cish Csf2rb Grap Btk Stat5a Epor Hck Tnfrsf10b Ptpru Stap1 Kitlg Socs4 Socs6 Cltc Dok1 Spred1 Vav2 Mpdz Fgr Spred2 Yes1 Ep300 Grb7 HYPOXIA DEPENDENT SELF RENEWAL OF MYOBLASTS%WIKIPATHWAYS_20260810%WP5023%MUS MUSCULUS Hypoxia dependent self renewal of myoblasts Myh1 Myf5 Hsp90b1 Foxo1 Notch1 Hif1a Hey2 Pax7 Hey1 Myod1 Cdkn1a Hes1 Myog MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260810%WP3626%MUS MUSCULUS Microglia pathogen phagocytosis pathway Lyn Pik3ca Pik3c2a Itgb2 Tyrobp Ncf4 C1qb C1qa Ncf1 Pik3c3 Lat Rac2 Syk Hck C1qc Rac3 Vav1 Cybb Pik3r3 Fcer1g Rac1 Pik3r1 Ncf2 Pik3r2 Vav3 Ptpn6 Arpc1b Itgam Vav2 Cyba Siglec12 Fcgr1 Pik3cg Plcg2 Trem3 Nckap1l Trem2 Pik3r6 Trem1 Pik3cb Pik3cd DYSREGULATED MIRNA TARGETING IN INSULIN PI3K AKT SIGNALING%WIKIPATHWAYS_20260810%WP3855%MUS MUSCULUS Dysregulated miRNA targeting in insulin PI3K AKT signaling Eif4e2 Bcl2l11 Rheb Bcl2 Acaca Socs1 Prkx Col5a3 Crkl Prkar2a Cdkn1b Pik3r3 Flot2 Mapk3 Ccnd2 Bad Pik3r1 Fasn Col1a2 Sos1 Col3a1 Col1a1 Col4a2 Mtor Exoc7 Raf1 TYPE II INTERFERON SIGNALING IFNG %WIKIPATHWAYS_20260810%WP1253%MUS MUSCULUS Type II interferon signaling IFNG Ifngr2 H4c14 Ifngr1 Reg1 Tap1 Ciita Irf8 Isg15 Irf9 Ifit2 Nos2 Eif2ak2 Socs1 Socs3 Cxcl10 Psmb9 Jak2 Jak1 Prkcd Il1b Irf4 Irf1 Cybb Irf2 Stat1 Ifng Icam1 Spi1 Ptpn11 Stat2 Cxcl9 Ifnb1 Gbp2b MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260810%WP385%MUS MUSCULUS Myometrial relaxation and contraction pathways Gsto1 Ets2 Nfkb1 Mylk2 Atf6b Ackr5 Gabpa Prkcb Prkca Gnb2 Gnb4 Prkcz Calca Maff Nos1 Jun Lpar1 Creb3 Prkar1b Gnas Prkd1 Gngt1 Prkcq Grk5 Prkar2a Prkcg Grk4 Prkch Grk6 Gnb1 Prkcd Gng3 Prkce Gnb5 Ywhah Gng2 Gng5 Gng4 Adcy3 Gng7 Adcy4 Gng8 Adcy1 Oxtr Adcy2 Adcy7 Cacnb3 Adcy8 Adcy5 Ywhaq Adcy6 Gnaq Adcy9 Prkacb Atf1 Fos Gabpb1 Plcg2 Camk2g Ryr2 Camk2d Camk2b Camk2a Plcg1 Arrb2 Arrb1 Itpr2 Itpr1 Ywhag Rgs4 Acta1 Rgs5 Nos3 Rgs2 Ywhae Rgs3 Igfbp2 Atf2 Crcp Ywhab Igfbp5 Slc8a1 Igfbp4 Gja1 Rgs9 Igfbp1 Rgs6 Rgs7 Myl4 Igfbp6 Myl2 Atf5 Calm3 Pkib Pkia Ywhaz Pkig Crhr1 Cnn1 Prkar1a Rln1 Sfn Gnb3 Itpr3 Ryr1 Atp2a3 Creb1 Rxfp2 Atp2a2 Rgs16 Rxfp1 Adm Ramp1 Ryr3 Guca2b Il1b Guca2a Cald1 Actb Pde4b Rgs20 Plcd1 Rgs17 Rgs18 Rgs19 Dgkz Rgs14 Pde4d Actc1 Prkar2b Rgs10 Rgs11 Corin Ramp3 Ramp2 Rgs1 Il6 Sp1 Actg1 Oxt Gng12 Atf3 Plcb3 Crh Igfbp3 Atf4 Ackr3 Gng11 Gng13 ROBO4 AND VEGF SIGNALING PATHWAYS CROSSTALK%WIKIPATHWAYS_20260810%WP3864%MUS MUSCULUS Robo4 and VEGF signaling pathways crosstalk Vegfa Robo4 Kdr Rac1 Slit2 Src REGULATION OF PGC1A EXPRESSION BY A GSK3B TFEB SIGNALING AXIS IN SKELETAL MUSCLE%WIKIPATHWAYS_20260810%WP4763%MUS MUSCULUS Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle Tfeb Gsk3b Ppargc1a MAPK SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP493%MUS MUSCULUS Mapk signaling pathway Map3k14 Map2k7 Akt3 Pla2g5 Rasa1 Pak1 Rap1a Rap1b Map4k1 Crkl Rps6ka3 Nfkb1 Mapk9 Mapk8 Hspa8 Mapk1 Map3k7 Mapk3 Tab2 Egfr Akt1 Crk Ppp3ca Prkcb Nr4a1 Kras Prkcz Raf1 Braf Nlk Map2k2 Fasl Map2k1 Tgfb3 Pak2 Casp6 Jun Il1a Mapk4 Flna Bdnf Map3k8 Cdc25b Akt2 Ngf Prkcg Prkch Prkcd Rac1 Tnf Il1r2 Hspa1a Fos Casp7 Casp1 Tgfb1 Ppp3cb Egf Arrb2 Tab1 Arrb1 Fgf4 Tgfbr2 Traf6 Ptprr Atf2 Max Ppp3r1 Dusp4 Elk1 Casp8 Map3k5 Stmn1 Dusp6 Map2k6 Tgfb2 Myc Hspb1 Traf2 Ptpn5 Mapk7 Cdc42 Dusp1 Mapkapk2 Map3k6 Mapk6 Mapk14 Ddit3 Map2k5 Il1b Map2k4 Map3k1 Mapk13 Nras Casp9 Grb2 Map4k4 Casp2 Tgfbr1 Map4k3 Daxx Map3k4 Trp53 Srf Map3k20 Pla2g10 Rasgrp4 Pdgfrb Rasgrp1 Rasa2 Stk3 Nf1 Pdgfb Hspb2 Ppp3cc Mink1 Rasgrf2 Hspa5 Ppp5c Ecsit Mapt Tmem37 Ppp3r2 Ppm1b Ppm1a Ptpn7 Mapk12 Ntf4 Dusp5 Dusp7 Dusp10 Map3k11 Cd14 Taok2 Map3k12 Prkaca Taok1 Map3k13 Mapkapk5 Jund Ntrk1 Mapk8ip3 Il1r1 Mras Rac2 Acvr1c Gadd45a Gck Sos2 Atf4 Acvr1b Gna12 Casp3 Mapk10 Mos Mef2c Ikbkb Fas Ikbkg DEREGULATION OF RENIN ANGIOTENSIN SYSTEM BY SARS COV INFECTION%WIKIPATHWAYS_20260810%WP4965%MUS MUSCULUS Deregulation of renin angiotensin system by SARS CoV infection Ace2 Agtr1a Agtr2 Ace SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260810%WP2141%MUS MUSCULUS Serotonin and anxiety Htr2c Htr2a Gabra1 Adra1a Htr1a Ppp3ca Fmr1 Pomc Fos Eef2 Trpv1 Prkcb Plcd4 Arc Crh Plek Grm1 Camk2b MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260810%WP2910%MUS MUSCULUS Mecp2 and associated Rett syndrome Fgf2 Tap1 Mag Fgf4 Mbp Ezh2 Hnrnpf Bdnf Pou3f2 Mecp2 Gamt Cnp Ybx1 Gprin1 Ncor1 Csrp1 Dlx5 Ctcf Smc3 Fut8 Pou4f1 Rbfox1 Apoc2 Creb1 Gabrr2 Cebpd Nrep Tet1 Myt1 Fgf3 Arhgef26 Rest Sst Taf1 Cdon Sp3 Grin1 Gad1 Mef2c Hnrnph1 Sp1 E2f1 Sin3a Prpf3 Nf1 Oprk1 Bcl6 FOLIC ACID NETWORK%WIKIPATHWAYS_20260810%WP1273%MUS MUSCULUS Folic acid network Gsr Mtr Kmo Ptgds Cat Pnpo Xdh Mthfr Selenok Selenow Alox5 Cbs Ptgis Ptges Msrb1 Txnrd1 Fads2 Gpx2 Gpx1 Gpx4 Txnrd2 Gpx3 Gpx6 G PROTEIN SIGNALING PATHWAYS%WIKIPATHWAYS_20260810%WP232%MUS MUSCULUS G protein signaling pathways Itpr1 Akap8 Prkar1a Gnb3 Akap1 Pde4b Nras Gna13 Arhgef1 Hras Pde4d Ppp3ca Prkar2b Prkd3 Prkcb Prkca Gnb2 Kras Prkcz Slc9a1 Ppp3cc Prkaca Gng12 Calm1 Kcnj3 Prkar1b Gnas Plcb3 Prkd1 Gnai2 Gngt1 Prkcq Gnai1 Prkar2a Prkcg Prkch Gnai3 Prkci Gnb1 Prkcd Gng3 Prkce Gnb5 Pde7b Rras Gng5 Pde7a Gng4 Rhoa Akap7 Adcy3 Akap5 Gna12 Gng7 Adcy4 Akap6 Gng8 Adcy1 Akap3 Gng10 Adcy2 Akap4 Adcy7 Gnaz Adcy8 Akap10 Adcy5 Akap11 Adcy6 Akap12 Akap9 Gnaq Adcy9 Akap13 Gngt2 Pde4a Prkacb Pde8a Pde8b Gna11 Gng11 Gna15 Gna14 Gng13 Gnao1 Gnal Pde4c Pde1b Pde1c Pde1a GENE REGULATORY NETWORK MODELLING SOMITOGENESIS %WIKIPATHWAYS_20260810%WP2852%MUS MUSCULUS Gene regulatory network modelling somitogenesis Ripply2 Tbx6 Notch1 Lfng Wnt3a Dll1 Hes1 Fgf8 Epha4 Mesp2 Hes7 GPCRS SMALL LIGAND%WIKIPATHWAYS_20260810%WP353%MUS MUSCULUS GPCRs small ligand Ptgdr S1pr1 Ptgfr S1pr2 Mtnr1b Ptger2 S1pr4 Cnr2 Ptger4 Lpar1 Ptger3 Ptger1 Mtnr1a Ptgir Cnr1 Ptafr Tbxa2r S1pr3 BDNF PATHWAY%WIKIPATHWAYS_20260810%WP2152%MUS MUSCULUS BDNF pathway Plat Frs2 Ntrk2 Bcl2 Ngfr Rac1 Trp53 Plg Shc1 Mapk4 Bdnf Serpine1 Cdc42 Creb1 Bax LAC PHE PATHWAY%WIKIPATHWAYS_20260810%WP5240%MUS MUSCULUS Lac Phe pathway Cndp2 Abcc5 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260810%WP207%MUS MUSCULUS Nucleotide GPCRs P2ry6 Lpar6 P2ry4 P2ry2 P2ry1 Adora1 Adora3 Ltb4r Adora2b Adora2a Lpar4 Tmigd3 PURINE METABOLISM%WIKIPATHWAYS_20260810%WP2185%MUS MUSCULUS Purine metabolism Gart Gda Entpd1 Nt5c Entpd2 Nt5c1a Pnp Atic Nt5e Pgm2 Nt5c1b Entpd5 Pde6g Entpd6 Pde6h Pgm1 Entpd3 Entpd4 Entpd8 Nt5m Allc Ak1 Prim2 Ak2 Prim1 Ak5 Ak4 Hprt1 Ak7 Polr1h Ak8 Cant1 Pole2 Ampd3 Pola2 Ampd2 Ampd1 Adcy10 Pnp2 Pola1 Npr2 Adprm Pde9a Gucy1b1 Gucy1b2 Nt5c3a Pnpt1 Itpa Polr3d Dguok Polr3e Adss2 Polr3b Pole Adss1 Polr3h Gucy1a2 Polr3k Ppat Paics Ada Pde10a Urad Adk Pde3a Urah Nudt16l2 Guk1 Pde2a Nudt16 Nme3 Gmps Prps1l3 Gmpr Nme5 Prps1l1 Nme4 Fhit Dck Nme1 Prps1 Gucy2e Ak6 Gucy2d Prps2 Gmpr2 Gucy2c Nme7 Nme6 Pde3b Polr2c Gucy2f Polr2a Pole3 Polr2b Impdh2 Taf9 Polr2d Polr2g Impdh1 Polr2e Pole4 Polr2f Enpp3 Pde5a Polr2i Polr2l Polr2j Aprt Polr3gl Nudt2 Polr1b Hddc3 Polr1c Nudt5 Polr1a Polr3a Nme2 Rrm1 Nudt9 Pde11a Polr1d Prune1 Polr3c Pde6c Polr1e Pde6d Pde6a Polr3f Adcy3 Pde6b Adcy4 Polr3g Adcy1 Pfas Adcy2 Papss2 Adcy7 Papss1 Adcy8 Nt5c2 Adcy5 Uox Adcy6 Adcy9 Rrm2b Xdh Adsl Polr2h Npr1 Rrm2 Pde4b Pde4d Pkm Pklr Enpp1 Pde7b Pde7a Pde4a Pde8a Pde8b Pold2 Pold1 Pold4 Pold3 Pde4c Pde1b Pde1c Pde1a ECTODYSPLASIN A SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260810%WP3652%MUS MUSCULUS Ectodysplasin A signaling in hair follicle development Rela Gli1 Eda Sostdc1 Edaradd Nfkb2 Edar Dkk4 Dkk1 Relb Shh Ptch1 Nfkb1 Ltb ELONGATION OF VERY LONG CHAIN FATTY ACIDS%WIKIPATHWAYS_20260810%WP4491%MUS MUSCULUS Elongation of very long chain fatty acids Fads1 Elovl4 Scd3 Elovl2 Elovl3 Elovl5 Scd1 Fasn Elovl1 Scd2 Scd4 Elovl6 Elovl7 Fads2 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260810%WP522%MUS MUSCULUS Biogenic amine synthesis Ddc Comt Pnmt Tph1 Th Maoa Gad1 Gad2 Aanat Hdc Ache Asmt Dbh Pah Chat NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260810%WP1242%MUS MUSCULUS Non homologous end joining Prkdc Rad50 Xrcc6 Xrcc5 Xrcc4 Nhej1 Mre11a STRIATED MUSCLE CONTRACTION%WIKIPATHWAYS_20260810%WP216%MUS MUSCULUS Striated muscle contraction Tnnt1 Casq2 Ttn Tnnc2 Tmod1 Tnnc1 Tcap Dmd Actn4 Acta2 Jsrp1 Acta1 Tpm4 Myh7 Smpx Tpm3 Tpm2 Tpm1 Neb Tnni3 Tnni2 Tnni1 Myl4 Myom1 Des Myl2 Myh3 Actn2 Mybpc1 Actn3 Mybpc2 Mybpc3 Myh8 Myh4 Myl9 Vim Myom2 Myh6 Myh1 Myl3 Actc1 Myl1 Tnnt3 Actg1 Tnnt2 TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260810%WP79%MUS MUSCULUS Tryptophan metabolism Inmt Cyp4f14 Cat Dhcr24 Echs1 Tph1 Hadh Aldh1a2 Maob Ube3a Ogdh Cyp2f2 Cyp1b1 Cyp7b1 Aldh3a2 Aldh9a1 Hsd17b10 Wars1 Ddc Tdo2 Prmt1 Cyp2j6 Cyp2e1 Aldh1a1 Aldh2 Cyp19a1 Cyp2c55 Aadat Ubr5 Aox1 Acat1 Afmid Aoc1 Haao Kynu Cyp1a1 Acmsd Ido1 Rnf25 Aanat Mdm2 Asmt Cyp1a2 Gcdh STATIN PATHWAY%WIKIPATHWAYS_20260810%WP1%MUS MUSCULUS Statin pathway Scarb1 Ldlr Mttp Hmgcr Apoa1 Lpl Pltp Apoc1 Lcat Apoe Apoa4 Abca1 Lrp1 Lipc Apoc3 Soat1 Dgat1 Cyp7a1 Apoc2 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260810%WP3592%MUS MUSCULUS ApoE and miR 146 in inflammation and atherosclerosis Nfkb2 Apoe Tlr2 Spi1 Irak1 Rela Traf6 Tlr4 GLUTATHIONE AND ONE CARBON METABOLISM%WIKIPATHWAYS_20260810%WP730%MUS MUSCULUS Glutathione and one carbon metabolism Gsr Mtr Mat2b Dnmt3b Ahcy Mtrr Amt Mthfr Cth Bhmt Shmt2 Shmt1 Gclc Cbs Gclm Ggt5 Dnmt1 Gss Idh1 Ggt1 Anpep Chdh G6pdx Gpx2 Gpx1 Gpx4 Mat1a Dnmt3a Gpx3 Oplah Ahcyl2 AMINO ACID METABOLISM%WIKIPATHWAYS_20260810%WP662%MUS MUSCULUS Amino acid metabolism Gsr Ftcd Tph1 Ehhadh Cth Bcat1 Auh Acaa1a Bhmt Gsta4 Got1 Got2 Wars1 Ass1 Tdo2 Ddc Tpo Asl Aldh1a1 Th Cbs Gclm Sdhd Lars2 Gss Tat Asns Sdha Aldh7a1 Vars1 Acss1 Farsb Hibch Pdhx Sds Pck1 Arg2 Aldh18a1 Gls Gpt2 Mccc1 Mars2 Sms Mpst Pcx Oat Glud1 Pycr1 Odc1 Acadm Cps1 Pkm Prodh Acly Adh5 Srm Cad Dld Rars1 Aoc3 Hmgcl Hadh Eprs1 Maoa Iars1 Fah Hal G6pc2 Ppm1l P4ha2 Cs Adh4 Hibadh Adh1 Mmut Suclg1 Otc Pdha1 Pdk4 Mdh1 Ogdh Mdh2 Ldha Arg1 Fh Dlst Aco2 Adh7 Pnmt Idh1 Hdc Glul Dbh Hmgcs2 Hnmt NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2074%MUS MUSCULUS Neural crest differentiation Id1 Tbx6 Dll3 Col11a2 Ets1 Nfkb1 Ctnnb1 Notch4 Cdh1 Myb Sox9 Notch2 Notch3 Dll1 Axin1 Dll4 Axin2 Hes1 Tcf7l1 Hes5 Rbpj Hdac3 Fgfr1 Hdac5 Tfap2a Wnt3a Dvl1 Hdac7 Dvl2 Hdac8 Dvl3 Mbp Wnt1 Rhob Tcf4 Gfap Ctbp2 Gbx2 Gsk3b Cdh2 Pax7 Smad1 Bmp4 Lhx1 Mitf Phox2b Nfkb2 Hdac6 Foxd3 Twist1 Fgf8 Ascl1 Hey2 Hdac2 Hdac4 Hand1 Hdac1 Isl1 Fgf2 Fgfr2 Sox5 Fgf15 Itgb1 Notch1 Neurog1 Cdh7 Dlx5 Cdh6 Mpz Col2a1 Mia Msx2 Msx3 Hoxb1 Prtg Olig3 Olig2 Olig1 Fgfr3 Tfap2b Bmp7 Hdac11 Hdac10 Sox10 Snai2 Snai1 Lhx2 Gjb1 Tlx2 Lhx5 Fzd3 Zic1 Dmbx1 Hdac9 Pax3 Dct Wnt8a Hoxa1 Pmp22 Zic5 SYNTHESIS AND DEGRADATION OF KETONE BODIES%WIKIPATHWAYS_20260810%WP543%MUS MUSCULUS Synthesis and degradation of ketone bodies Bdh1 Oxct1 Acat1 Hmgcs2 Hmgcl ALPHA 6 BETA 4 INTEGRIN SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP488%MUS MUSCULUS Alpha 6 beta 4 integrin signaling pathway Rpsa Cd151 Smad2 Erbb2 Itgb4 Abl1 Dsp Ywhae Ywhab Shc1 Src Plec Lama1 Trp73 Pak1 Irs1 Irs2 Ptk2 Ywhaz Met Sfn Vim Lama2 Lama3 Eif4e Egfr Bad Grb2 Itga6 Pik3r1 Akt1 Pik3r2 Rtkn Mtor Prkca Pik3cg Fyn Pik3cb Pik3cd Pik3ca Mmp7 Ar Smad3 Ntn1 Prkcd Eif4ebp1 Ywhah Pik3r3 Rhoa Lamb3 Casp3 Lamb2 Rac1 Lamb1 Lama5 Yes1 Eif6 Clca1 Clca2 Lamc1 Dst Lamc2 Erbin Mst1r Cdkn1a Col17a1 CELL CYCLE%WIKIPATHWAYS_20260810%WP190%MUS MUSCULUS Cell cycle Espl1 Mad2l1 Ccne2 Bub1b Bub3 Ccna2 Mpeg1 Bub1 Cdc14b Cdc14a Ccnb2 Plk1 Ywhag Ccnb3 Abl1 Pttg1 Ccnb1 Cdc7 Cdc6 Mad1l1 Ccna1 Tbc1d8 Mcm7 Cdkn2a Smc1b Tfdp1 Hdac6 Pkmyt1 Chek1 Mcm3 Chek2 Mcm4 Mcm5 Mcm6 Mcm2 Cdc25a Cdkn1b Orc5 Orc4 Orc6 Skp2 Orc1 Cdk6 Orc3 Cdk4 Orc2 Cdc45 Atr Wee1 E2f2 Cdh1 E2f3 E2f5 E2f6 Trp53 Cdk2 Mdm2 Hdac2 Hdac4 Cdc25c Hdac1 Hdac3 Hdac5 Prkdc Ccne1 Hdac7 Ccnh Rbl1 Cdc25b Smad3 Smad4 Gadd45a Cdk1 Rb1 Ccnd2 Ccnd3 Gsk3b Ep300 E2f1 Tgfb1 E2f4 Cdkn1a Pcna Dbf4 Cdc20 Atm Mad2l2 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260810%WP2075%MUS MUSCULUS Alzheimer 39 s disease Aph1a Itpr2 Itpr1 Lpl Cacna1f Cacna1c Atp2a1 Cacna1d Ppp3r1 Apbb1 Ide Cacna1s Casp8 Bace1 Chp1 Chp2 Cdk5r1 App Plcb1 Ern1 Atf6 Psen1 Calm4 Itpr3 Adam17 Fadd Calm2 Bid Atp2a3 Calml3 Atp2a2 Adam10 Nae1 Casp12 Cdk5 Ryr3 Hsd17b10 Grin2c Il1b Mapk1 Mapk3 Casp9 Bad Psenen Apaf1 Ppp3ca Trp53 Capn1 Psen2 Capn2 Apoe Ncstn Ppp3cc Mapt Ppp3r2 Plcb4 Nos1 Eif2ak3 Plcb3 Grin2d Grin2a Plcb2 Tnfrsf1a Casp3 Grin2b Grin1 Tnf Gnaq Gsk3b Lrp1 Casp7 Fas Ppp3cb Mme Snca CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260810%WP553%MUS MUSCULUS Calcium regulation in cardiac cells Atp1b1 Cacna1c Cacna1d Cacna1s Cacna1e Gja3 Gja8 Slc8a3 Fxyd2 Gjc1 Gjc2 Gjb2 Gjb4 Gjb3 Gjb6 Gjb5 Casq1 Atp2b2 Atp2b3 Camk4 Gjd2 Atp1a4 Camk1 Prkcb Kcnb1 Kcnj5 Anxa6 Pln Cacna1a Atp1b3 Cacna1b Prkca Atp1b2 Gnb2 Gnb4 Prkcz Adra1b Adrb3 Adra1a Adra1d Kcnj3 Prkar1b Gnas Prkd1 Gngt1 Atp2b1 Prkcq Grk5 Prkar2a Prkcg Grk4 Prkch Grk6 Gnb1 Prkcd Gng3 Prkce Gnb5 Ywhah Gng2 Gng5 Gng4 Adcy3 Calr Gng7 Adcy4 Gng8 Adcy1 Adcy2 Fkbp1a Adcy7 Cacnb3 Adcy8 Adcy5 Cacnb1 Ywhaq Adcy6 Gnaq Adcy9 Prkacb Camk2g Ryr2 Camk2d Camk2b Camk2a Arrb2 Casq2 Arrb1 Itpr2 Itpr1 Gja5 Ywhag Rgs4 Rgs5 Rgs2 Ywhae Rgs3 Ywhab Slc8a1 Gja1 Rgs9 Rgs6 Rgs7 Calm3 Pkib Pkia Ywhaz Pkig Prkar1a Sfn Gnb3 Itpr3 Ryr1 Atp2a3 Atp2a2 Rgs16 Ryr3 Rgs20 Rgs17 Rgs18 Rgs19 Rgs14 Prkar2b Rgs10 Rgs11 Chrm1 Chrm3 Rgs1 Chrm2 Chrm5 Chrm4 Adrb2 Adrb1 Gng12 Plcb3 Gnai2 Gnai1 Gnai3 Gja4 Gjb1 Gnaz Gng11 Gna11 Gng13 Gnao1 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260810%WP1250%MUS MUSCULUS Arachidonate epoxygenase epoxide hydrolase Cox5a Ephx2 Cox8a COMPREHENSIVE IL 17A SIGNALING%WIKIPATHWAYS_20260810%WP5242%MUS MUSCULUS Comprehensive IL 17A signaling Ccl5 Smad7 Pura Ppp1r14b Mcm7 Mcm3 Mcm4 Ptgs2 Psmc6 Mcm5 Mcm6 Mcm2 Jak2 Orc1 Orc2 Rela Egfr Akt1 Anxa6 Mtor Sod2 Serbp1 Hyou1 Cacybp Hbb-b1 Uggt1 Becn1 Plch1 Cpne1 Nasp Nucks1 Hmgb1 Fbn1 Hbb-bh1 Mmp14 Blmh Stat3 Bcl2 Upf1 Samhd1 Mmp3 Map1lc3a Angpt1 Map1lc3b Pon3 Hspa1b Hbb-bs Tjp1 Atox1 Adh1 C7 Cxcl12 Smad3 Tnfsf13b Gap43 Rhoa Sqstm1 Plau Rac1 Rab10 Mki67 Prkacb Tgfb1 Pcna Arpc3 Arpc2 Smad2 Cxcl1 Cxcl5 Acta2 Ccn2 Smad6 Plaur Acta1 Ccl4 Ccl3 Cdc42 Cxcl2 Il1b Cxcl15 Stat1 Trp53 Npm1 Pak3 Il6 Pdgfa Rras2 Pdgfb Igf1 Mylk Arpc5 C3 Gng12 Mmp9 Pik3c3 Atrx Fn1 Zmpste24 Snai2 Snai1 Casp3 Rbbp4 Col1a1 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260810%WP2928%MUS MUSCULUS miR 222 in exercise induced cardiac growth Hmbox1 Hipk1 Hipk2 Cdkn1b PARKINSON 39 S DISEASE%WIKIPATHWAYS_20260810%WP3638%MUS MUSCULUS Parkinson 39 s disease Ccne2 Ccne1 Mapk12 Gpr37 Casp6 Eprs1 Atxn2 Pink1 Park7 Syt11 Lrrk2 Htra2 Ube2g2 Ube2g1 Sncaip Prkn Septin5 Ube2l6 Uba7 Ube2j2 Ubb Ube2l3 Mapk14 Ube2j1 Ddc Uchl1 Mapk13 Casp9 Casp3 Uba1 Casp2 Apaf1 Th Slc6a3 Mapk11 Casp7 Cycs Snca PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260810%WP201%MUS MUSCULUS Ptf1a related regulatory pathway Pdx1 Prox1 Rbpj Ptf1a Notch1 Fgf10 Ctnnb1 Rbpjl Kat2b Nkx6-1 Hes1 EICOSANOID LIPID SYNTHESIS MAP%WIKIPATHWAYS_20260810%WP4335%MUS MUSCULUS Eicosanoid lipid synthesis map Pla2g4b Pla2g4a Ptgds Pgs1 Ptges Pla2g5 Ptgs2 Pla2g6 Alox5 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260810%WP449%MUS MUSCULUS Complement and coagulation cascades Plaur Cr2 C5ar1 C3ar1 F2r Bdkrb1 Cfd F3 Cfb Fgb F10 Vwf C1qb F12 C1qa C1ra F11 Masp1 Plg C3 F2 F5 F7 C2 C4b F8 F9 Serpinf2 C5 F13b C1s1 C6 C7 C9 Cd55 Plat C1qc Serping1 Mbl1 C4bpa Masp2 Tfpi Serpina5 C8g Plau Cd59a Cfh Cfi Klkb1 Proc Cr1l Serpind1 Cd46 Thbd Pros1 Serpinc1 A2m Cpb2 Serpine1 Cd55b Kng1 NOVEL JUN DMP1 PATHWAY%WIKIPATHWAYS_20260810%WP3654%MUS MUSCULUS Novel Jun Dmp1 pathway Braf Map2k2 Map2k1 Araf Cdkn2a Jun Ccnd1 Ets1 Ets2 Myc Mapk1 Cdk4 Rb1 Rras Mapk3 Nras Hras Trp53 Arf1 Fos Mdm2 E2f1 Dmp1 Junb Kras Raf1 IL 6 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP387%MUS MUSCULUS IL 6 signaling pathway Erbb2 Ppp2cb Ppp2r5d Ppp2r5b Ppp2r5a Pxn Socs3 Cdk5r1 Hsp90aa1 Nfkb1 Foxo3 Jak2 Ptpa Cdk5 Jak1 Rps6ka2 Ppp2r2a Mapk8 Mapk1 Gab2 Map3k7 Vav1 Mapk3 Eif4e Pik3r1 Akt1 Pik3r2 Sos1 Tyk2 Ppp2ca Inpp5d Rps6kb1 Ptpn11 Fes Fyn Raf1 Lyn Ptk2b Nlk Bmx Map2k2 Stat5b Ppp2r1a Map2k1 Stat3 Jun Foxo4 Btk Ar Gab1 Cdk9 Prkcd Hck Ppp2r5c Sgk1 Ppp2r5e Rac1 Gsk3b Fos Fgr Ep300 Eif2a Crebbp Plcg1 Shc1 Ptk2 Map2k6 Il6ra Tec Hspb1 Mapkapk2 Mapk14 Map2k4 Casp9 Stat1 Grb2 Bad Daxx Hras Map3k4 Erbb3 Il6 Hdac1 Mapt Hnf1a Inppl1 Foxo1 Il6st Ppp2r3a Ppp2r2c Ppp2r2b Stat5a Cebpb Eif4ebp1 Ncoa1 Rb1 Casp3 Cd40 Ppp2r1b GLYCOGEN METABOLISM%WIKIPATHWAYS_20260810%WP317%MUS MUSCULUS Glycogen metabolism Phkg1 Phkg2 Agl Pygl Pygm Ppp2r1a Ppp2cb Ppp2r5d Ppp2r5b Ppp2r5a Ugp2 Pgm1 Calm3 Calm1 Ppp2r3a Ppp2r2c Calm2 Ppp2r2b Ptpa Gyg1 Ppp2r2a Ppp2r5c Ppp2r5e Gsk3b Ppp2ca Ppp2r1b Gsk3a Gbe1 Phkb Gys1 Phka1 Gys2 Phka2 Pygb IL 7 SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP297%MUS MUSCULUS IL 7 signaling pathway Lyn Ptk2b Ccna2 Map2k2 Stat5b Bcl2l11 Map2k1 Stat3 Shc1 Foxo1 Irs1 Irs2 Jak3 Foxo3 Il7r Stat5a Jak1 Stam2 Mapk1 Cblb Cdk4 Rb1 Irf1 Mapk3 Muc1 Ccnd2 Stat1 Bad Grb2 Pik3r1 Hras Akt1 Mcl1 Sos1 Gsk3b Cltc Stam Cbl Il2rg Cdk2 Blk Fyn Bax Raf1}