SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME DATABASE ID RELEASE 97%1855231 Synthesis of IPs in the ER lumen MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME DATABASE ID RELEASE 97%9916720 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 97%162589 Reverse Transcription of HIV RNA NEGATIVE TRANSCRIPTIONAL REGULATION OF UREA CYCLE ENZYMES%REACTOME DATABASE ID RELEASE 97%9988426 Negative transcriptional regulation of urea cycle enzymes GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME%R-HSA-1483206.8 Glycerophospholipid biosynthesis PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1251932 PLCG1 events in ERBB2 signaling REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.5 Regulation of PLK1 Activity at G2 M Transition BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 97%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.6 Degradation of the extracellular matrix EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME%R-HSA-212165.7 Epigenetic regulation of gene expression ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.4 Antimicrobial peptides SOMITOGENESIS%REACTOME%R-HSA-9824272.2 Somitogenesis BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196780 Biotin transport and metabolism SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME%R-HSA-9605310.4 Defective Base Excision Repair Associated with MUTYH REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.6 Regulation of mRNA stability by proteins that bind AU-rich elements HEDGEHOG 'OFF' STATE%REACTOME%R-HSA-5610787.3 Hedgehog 'off' state MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME%R-HSA-9939291.2 Matriglycan biosynthesis on DAG1 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 97%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.4 Alternative complement activation HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162587 HIV Life Cycle CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 97%9909505 Modulation of host responses by IFN-stimulated genes RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 97%177504 Retrograde neurotrophin signalling BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 97%196299 Beta-catenin phosphorylation cascade RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 97%9665251 Resistance of ERBB2 KD mutants to lapatinib PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 97%8949664 Processing of SMDT1 KIDNEY DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9830369 Kidney development SIGNALING BY ALK%REACTOME DATABASE ID RELEASE 97%201556 Signaling by ALK FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 97%167152 Formation of HIV elongation complex in the absence of HIV Tat REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9759811.1 Regulation of CDH11 mRNA translation by microRNAs RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 97%8951936 RUNX3 regulates p14-ARF BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 97%9018682 Biosynthesis of maresins DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME%R-HSA-9665737.2 Drug resistance in ERBB2 TMD JMD mutants NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866904.4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 97%8853884 Transcriptional Regulation by VENTX SARS-COV-2 INFECTION%REACTOME DATABASE ID RELEASE 97%9694516 SARS-CoV-2 Infection TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 97%418359 Reduction of cytosolic Ca++ levels HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%629597 Highly calcium permeable nicotinic acetylcholine receptors PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME DATABASE ID RELEASE 97%9843940 Regulation of endogenous retroelements by KRAB-ZFP proteins DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579016.5 Defective UGT1A4 causes hyperbilirubinemia DEFECTIVE GALE CAUSES EDG%REACTOME DATABASE ID RELEASE 97%5609977 Defective GALE causes EDG INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.4 Intestinal saccharidase deficiencies PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 97%1912422 Pre-NOTCH Expression and Processing SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 97%198765 Signalling to ERK5 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 97%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 97%8848021 Signaling by PTK6 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.3 SUMO is conjugated to E1 (UBA2:SAE1) VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%434313 Intracellular metabolism of fatty acids regulates insulin secretion SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 97%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript DEFECTIVE ABCD1 CAUSES ALD%REACTOME DATABASE ID RELEASE 97%5684045 Defective ABCD1 causes ALD TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.8 Ligand-dependent caspase activation FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME DATABASE ID RELEASE 97%9032845 Activated NTRK2 signals through CDK5 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME%R-HSA-8857538.4 PTK6 promotes HIF1A stabilization DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME%R-HSA-5619107.4 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170968 Frs2-mediated activation FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654706 FRS-mediated FGFR3 signaling TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8866423 VLDL assembly REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 97%176408 Regulation of APC C activators between G1 S and early anaphase MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E METABOLISM%REACTOME DATABASE ID RELEASE 97%1430728 Metabolism PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%156580 Phase II - Conjugation of compounds SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209931 Serotonin and melatonin biosynthesis INFLAMMASOMES%REACTOME DATABASE ID RELEASE 97%622312 Inflammasomes THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 97%167826 The fatty acid cycling model ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects CYTOSOLIC TRNA AMINOACYLATION%REACTOME%R-HSA-379716.3 Cytosolic tRNA aminoacylation MET ACTIVATES RAP1 AND RAC1%REACTOME DATABASE ID RELEASE 97%8875555 MET activates RAP1 and RAC1 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807062 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) CO-INHIBITION BY BTLA%REACTOME%R-HSA-9927353.2 Co-inhibition by BTLA EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190377 FGFR2b ligand binding and activation SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 97%9834899 Specification of the neural plate border INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 97%71291 Amino acid and derivative metabolism SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 97%198745 Signalling to STAT3 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.4 Factors involved in megakaryocyte development and platelet production DIGESTION%REACTOME%R-HSA-8935690.7 Digestion RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.3 Suppression of phagosomal maturation INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020591 Interleukin-12 signaling REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME DATABASE ID RELEASE 97%9917777 Epigenetic regulation by WDR5-containing histone modifying complexes METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196849 Metabolism of water-soluble vitamins and cofactors ERKS ARE INACTIVATED%REACTOME%R-HSA-202670.4 ERKs are inactivated CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response TRANSCRIPTIONAL REGULATION BY TP53%REACTOME DATABASE ID RELEASE 97%3700989 Transcriptional Regulation by TP53 CREATINE METABOLISM%REACTOME%R-HSA-71288.3 Creatine metabolism TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602410 TLR3 deficiency - HSE CHROMATIN MODIFYING ENZYMES%REACTOME%R-HSA-3247509.6 Chromatin modifying enzymes INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.6 Transport of vitamins, nucleosides, and related molecules RND3 GTPASE CYCLE%REACTOME%R-HSA-9696264.2 RND3 GTPase cycle SUNITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669934.2 Sunitinib-resistant KIT mutants BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME DATABASE ID RELEASE 97%5619096 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 97%9603505 NTRK3 as a dependence receptor SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 97%166020 Transfer of LPS from LBP carrier to CD14 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 97%9845619 Enhanced cleavage of VWF variant by ADAMTS13 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME%R-HSA-9716542.4 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 DIFFERENTIATION OF T CELLS%REACTOME%R-HSA-9945266.2 Differentiation of T cells NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 97%446210 Synthesis of UDP-N-acetyl-glucosamine TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 97%5357786 TNFR1-induced proapoptotic signaling FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%201722 Formation of the beta-catenin:TCF transactivating complex PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.3 Passive transport by Aquaporins DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME%R-HSA-5610783.2 Degradation of GLI2 by the proteasome REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 DIFFERENTIATION OF CIRCULATING MONOCYTES%REACTOME%R-HSA-9968734.1 Differentiation of Circulating Monocytes N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 97%975576 N-glycan antennae elongation in the medial trans-Golgi MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 97%450294 MAP kinase activation GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.14 Generic Transcription Pathway COMPLEX I BIOGENESIS%REACTOME DATABASE ID RELEASE 97%6799198 Complex I biogenesis PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME%R-HSA-9931510.1 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.6 tRNA processing in the mitochondrion COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 97%9769740 Coagulation pathway MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 97%166187 Mitochondrial Uncoupling LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162599 Late Phase of HIV Life Cycle SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME%R-HSA-442720.6 CREB1 phosphorylation through the activation of Adenylate Cyclase DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3906995 Diseases associated with O-glycosylation of proteins INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%168273 Influenza Viral RNA Transcription and Replication RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 97%5693537 Resolution of D-Loop Structures DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 97%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) VIRAL STRATEGIES TO EVADE IFIT ACTION%REACTOME%R-HSA-9690722.1 Viral strategies to evade IFIT action ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) ION CHANNEL TRANSPORT%REACTOME%R-HSA-983712.4 Ion channel transport TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME DATABASE ID RELEASE 97%9662851 Anti-inflammatory response favouring Leishmania parasite infection DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 97%5654741 Signaling by FGFR3 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 97%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 97%5619113 Defective SLC3A1 causes cystinuria (CSNU) FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190370 FGFR1b ligand binding and activation TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME%R-HSA-210455.4 Astrocytic Glutamate-Glutamine Uptake And Metabolism ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112122 ALKBH2 mediated reversal of alkylation damage SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 97%171286 Synthesis and processing of ENV and VPU MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9683610.5 Maturation of nucleoprotein KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 97%74182 Ketone body metabolism RHO GTPASES ACTIVATE IQGAPS%REACTOME%R-HSA-5626467.3 RHO GTPases activate IQGAPs SENSORY PERCEPTION OF SALTY TASTE%REACTOME%R-HSA-9730628.2 Sensory perception of salty taste N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 97%975577 N-Glycan antennae elongation NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 97%3301854 Nuclear Pore Complex (NPC) Disassembly AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.3 AKT-mediated inactivation of FOXO1A ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 97%5579026 Defective CYP11A1 causes AICSR ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME%R-HSA-1638091.4 Heparan sulfate heparin (HS-GAG) metabolism GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432722 Golgi Associated Vesicle Biogenesis THYROXINE BIOSYNTHESIS%REACTOME%R-HSA-209968.6 Thyroxine biosynthesis DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 97%5688849 Defective CSF2RB causes SMDP5 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380320 Recruitment of NuMA to mitotic centrosomes G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME%R-HSA-397795.6 G-protein beta:gamma signalling GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%982772 Growth hormone receptor signaling UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2142789 Ubiquinol biosynthesis BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%3858494 Beta-catenin independent WNT signaling GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 97%190873 Gap junction degradation RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8931987 RUNX1 regulates estrogen receptor mediated transcription DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 97%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) MAPLE SYRUP URINE DISEASE%REACTOME DATABASE ID RELEASE 97%9865114 Maple Syrup Urine Disease NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717301.2 NVP-TAE684-resistant ALK mutants P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 97%69563 p53-Dependent G1 DNA Damage Response INTRAFLAGELLAR TRANSPORT%REACTOME DATABASE ID RELEASE 97%5620924 Intraflagellar transport SIGNALING BY AMER1 MUTANTS%REACTOME DATABASE ID RELEASE 97%4839748 Signaling by AMER1 mutants REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 97%400206 Regulation of lipid metabolism by PPARalpha ASP-3026-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717264.3 ASP-3026-resistant ALK mutants ERK MAPK TARGETS%REACTOME%R-HSA-198753.3 ERK MAPK targets DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME%R-HSA-5579000.3 Defective CYP1B1 causes Glaucoma LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.3 LGI-ADAM interactions DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME DATABASE ID RELEASE 97%3323169 Defects in biotin (Btn) metabolism ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390651 Dopamine receptors CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 97%380615 Clearance of seratonin ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME DATABASE ID RELEASE 97%400042 Adrenaline,noradrenaline inhibits insulin secretion DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%8978868 Fatty acid metabolism TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%399719 Trafficking of AMPA receptors ADENOSINE P1 RECEPTORS%REACTOME DATABASE ID RELEASE 97%417973 Adenosine P1 receptors IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants SIGNALING BY FGFR2%REACTOME DATABASE ID RELEASE 97%5654738 Signaling by FGFR2 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 97%9766229 Degradation of CDH1 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029480 Fcgamma receptor (FCGR) dependent phagocytosis FORMATION OF THE CORNIFIED ENVELOPE%REACTOME DATABASE ID RELEASE 97%6809371 Formation of the cornified envelope APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME%R-HSA-111471.6 Apoptotic factor-mediated response NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 97%392154 Nitric oxide stimulates guanylate cyclase INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME DATABASE ID RELEASE 97%9670095 Inhibition of DNA recombination at telomere MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%8851907 MET activates PI3K AKT signaling DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69618 Mitotic Spindle Checkpoint NETRIN MEDIATED REPULSION SIGNALS%REACTOME DATABASE ID RELEASE 97%418886 Netrin mediated repulsion signals PEXOPHAGY%REACTOME DATABASE ID RELEASE 97%9664873 Pexophagy TYROSINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8963684 Tyrosine catabolism SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME%R-HSA-9692912.2 SARS-CoV-1 targets PDZ proteins in cell-cell junction DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 97%9608287 Defective MUTYH substrate binding SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702624.2 sorafenib-resistant FLT3 mutants ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 97%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 97%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.3 Activation of RAC1 downstream of NMDARs LEISHMANIA INFECTION%REACTOME DATABASE ID RELEASE 97%9658195 Leishmania infection SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9909438 3-Methylcrotonyl-CoA carboxylase deficiency MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9816359.2 Maternal to zygotic transition (MZT) NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME%R-HSA-9818035.1 NFE2L2 regulating ER-stress associated genes NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9025046 NTF3 activates NTRK2 (TRKB) signaling RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME DATABASE ID RELEASE 97%9954709 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 97%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism SIGNALING BY TGFB FAMILY MEMBERS%REACTOME DATABASE ID RELEASE 97%9006936 Signaling by TGFB family members PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%3296197 Hydroxycarboxylic acid-binding receptors TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation CHD3, CHD4, CHD5 SUBFAMILY%REACTOME%R-HSA-9943965.1 CHD3, CHD4, CHD5 subfamily SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME%R-HSA-5619047.4 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression SIGNALING BY RAS GTPASE MUTANTS%REACTOME DATABASE ID RELEASE 97%9753512 Signaling by RAS GTPase mutants BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 97%210993 Tie2 Signaling M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME%R-HSA-9820841.1 M-decay: degradation of maternal mRNAs by maternally stored factors CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) LDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964038 LDL clearance ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME%R-HSA-181431.9 Acetylcholine binding and downstream events SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 97%74749 Signal attenuation ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-75108.6 Activation of BID and translocation to mitochondria REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.4 Regulation of IFNG signaling SPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9845614 Sphingolipid catabolism REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 97%9010553 Regulation of expression of SLITs and ROBOs EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9851695 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME%R-HSA-9630221.2 Defective NTHL1 substrate processing PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.3 Synthesis of IPs in the nucleus SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME%R-HSA-1660516.9 Synthesis of PIPs at the early endosome membrane DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME DATABASE ID RELEASE 97%9672391 Defective F8 cleavage by thrombin GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%1306955 GRB7 events in ERBB2 signaling COLLAGEN FORMATION%REACTOME DATABASE ID RELEASE 97%1474290 Collagen formation DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME%R-HSA-5579007.3 Defective ACY1 causes encephalopathy DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%212676 Dopamine Neurotransmitter Release Cycle LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933937 Formation of the canonical BAF (cBAF) complex ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 97%901032 ER Quality Control Compartment (ERQC) PRIMITIVE STREAK FORMATION%REACTOME DATABASE ID RELEASE 97%9754189 Primitive streak formation MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 97%2206285 MPS VI - Maroteaux-Lamy syndrome PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 97%1257604 PI3K AKT Signaling REGULATED NECROSIS%REACTOME%R-HSA-5218859.6 Regulated Necrosis G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events DISEASE%REACTOME DATABASE ID RELEASE 97%1643685 Disease SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 97%9754678 SARS-CoV-2 modulates host translation machinery SYNTHESIS OF PI%REACTOME%R-HSA-1483226.5 Synthesis of PI BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%164525 Plus-strand DNA synthesis PI-3K CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654689 PI-3K cascade:FGFR1 SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.4 Signaling by Insulin receptor ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9033807 ABO blood group biosynthesis CASP4 INFLAMMASOME ASSEMBLY%REACTOME%R-HSA-9948001.1 CASP4 inflammasome assembly LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME%R-HSA-9623433.2 LXRs regulate gene expression to control bile acid homeostasis PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs VITAMINS%REACTOME DATABASE ID RELEASE 97%211916 Vitamins DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 97%114516 Disinhibition of SNARE formation SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 97%372708 p130Cas linkage to MAPK signaling for integrins DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%168275 Entry of Influenza Virion into Host Cell via Endocytosis AQUAPORIN-MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 97%445717 Aquaporin-mediated transport CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 97%5579031 Defective ACTH causes obesity and POMCD ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%2122948 Activated NOTCH1 Transmits Signal to the Nucleus MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME DATABASE ID RELEASE 97%5389840 Mitochondrial translation elongation AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 97%110312 Translesion synthesis by REV1 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 97%9734779 Developmental Cell Lineages of the Integumentary System AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME%R-HSA-9665247.2 Resistance of ERBB2 KD mutants to osimertinib APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 97%180689 APOBEC3G mediated resistance to HIV-1 infection SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9865881 Complex III assembly SIGNALING BY ERBB2 IN CANCER%REACTOME%R-HSA-1227990.6 Signaling by ERBB2 in Cancer RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%111457 Release of apoptotic factors from the mitochondria INITIATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769735 Initiation of coagulation cascade PYROPTOSIS%REACTOME DATABASE ID RELEASE 97%5620971 Pyroptosis REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9857377 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 97%2408552 Methylation of MeSeH for excretion EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME%R-HSA-174403.7 Glutathione synthesis and recycling ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 97%5662853 Essential pentosuria INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 97%8985947 Interleukin-9 signaling BIOFILM FORMATION%REACTOME%R-HSA-9931953.1 Biofilm formation FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190371 FGFR3b ligand binding and activation DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5687613 Diseases associated with surfactant metabolism MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%5660489 MTF1 activates gene expression REPLICATION OF THE SARS-COV-2 GENOME%REACTOME DATABASE ID RELEASE 97%9694686 Replication of the SARS-CoV-2 genome ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.3 Signaling by EGFRvIII in Cancer TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 97%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.8 Processing of Capped Intron-Containing Pre-mRNA AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 97%5083636 Defective GALNT12 causes CRCS1 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 97%9007101 Rab regulation of trafficking HSF1 ACTIVATION%REACTOME%R-HSA-3371511.4 HSF1 activation TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%446107 Type I hemidesmosome assembly POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 97%389977 Post-chaperonin tubulin folding pathway PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%9856649 Transcriptional and post-translational regulation of MITF-M expression and activity APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME DATABASE ID RELEASE 97%389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%111465 Apoptotic cleavage of cellular proteins DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 97%4724289 Defective ALG6 causes CDG-1c DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 97%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 97%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 97%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 97%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.3 Constitutive Signaling by AKT1 E17K in Cancer METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 97%5579029 Metabolic disorders of biological oxidation enzymes BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME%R-HSA-9909620.2 Regulation of PD-L1(CD274) translation WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 97%5099900 WNT5A-dependent internalization of FZD4 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.2 Defective FV causes thrombophilia RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 97%2466712 Biosynthesis of A2E, implicated in retinal degradation MEIOSIS%REACTOME DATABASE ID RELEASE 97%1500620 Meiosis PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 97%4086400 PCP CE pathway PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.2 pexidartinib-resistant FLT3 mutants CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 97%9703648 Signaling by FLT3 ITD and TKD mutants SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME DATABASE ID RELEASE 97%3304351 Signaling by TGF-beta Receptor Complex in Cancer BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME%R-HSA-9022702.2 MECP2 regulates transcription of neuronal ligands NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 97%9930044 Nuclear RNA decay MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.4 Physiological factors ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME DATABASE ID RELEASE 97%170670 Adenylate cyclase inhibitory pathway ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 97%9754706 Atorvastatin ADME INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME%R-HSA-8875360.5 InlB-mediated entry of Listeria monocytogenes into host cell DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 97%5578998 Defective OPLAH causes OPLAHD RHOBTB3 ATPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706019 RHOBTB3 ATPase cycle SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 97%73863 RNA Polymerase I Transcription Termination AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 97%9619483 Activation of AMPK downstream of NMDARs ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 97%1482801 Acyl chain remodelling of PS DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 97%69190 DNA strand elongation DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 97%5688890 Defective CSF2RA causes SMDP4 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.4 Incretin synthesis, secretion, and inactivation ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME%R-HSA-211728.4 Regulation of PAK-2p34 activity by PS-GAP RHG10 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.4 Tachykinin receptors bind tachykinins HDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964011 HDL clearance LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-5632681.2 Ligand-receptor interactions RHO GTPASE CYCLE%REACTOME%R-HSA-9012999.4 RHO GTPase cycle PI3K AKT ACTIVATION%REACTOME DATABASE ID RELEASE 97%198203 PI3K AKT activation REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9768727 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 97%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) VPU MEDIATED DEGRADATION OF CD4%REACTOME DATABASE ID RELEASE 97%180534 Vpu mediated degradation of CD4 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME DATABASE ID RELEASE 97%5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%5652084 Fructose metabolism SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 97%209563 Axonal growth stimulation CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.5 Cleavage of the damaged purine SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME%R-HSA-381771.6 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) SIGNALING BY EGFR%REACTOME DATABASE ID RELEASE 97%177929 Signaling by EGFR ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.2 ERBB2 Activates PTK6 Signaling GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation REPRESSION OF WNT TARGET GENES%REACTOME DATABASE ID RELEASE 97%4641265 Repression of WNT target genes NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839126 FGFR2 mutant receptor activation REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764265 Regulation of CDH1 Expression and Function HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones HEME SIGNALING%REACTOME%R-HSA-9707616.4 Heme signaling INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%1483249 Inositol phosphate metabolism ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME%R-HSA-9638630.1 Attachment of bacteria to epithelial cells SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665348 Signaling by ERBB2 ECD mutants POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME DATABASE ID RELEASE 97%174411 Polymerase switching on the C-strand of the telomere FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190242 FGFR1 ligand binding and activation DAP12 SIGNALING%REACTOME DATABASE ID RELEASE 97%2424491 DAP12 signaling FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 97%5578996 Defective CYP27A1 causes CTX RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME DATABASE ID RELEASE 97%73933 Resolution of Abasic Sites (AP sites) DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME%R-HSA-5619053.4 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%1839124 FGFR1 mutant receptor activation IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 97%1855229 IP6 and IP7 transport between cytosol and nucleus SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%5638302 Signaling by Overexpressed Wild-Type EGFR in Cancer BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis PEPTIDE HORMONE METABOLISM%REACTOME DATABASE ID RELEASE 97%2980736 Peptide hormone metabolism INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020956 Interleukin-27 signaling SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.3 Trafficking and processing of endosomal TLR RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%5213460 RIPK1-mediated regulated necrosis TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME DATABASE ID RELEASE 97%4717374 Defective DPM1 causes CDG-1e NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654726 Negative regulation of FGFR1 signaling SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 97%5654743 Signaling by FGFR4 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013424 RHOV GTPase cycle N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373755 Semaphorin interactions PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 PREDNISONE ADME%REACTOME%R-HSA-9757110.4 Prednisone ADME MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME%R-HSA-9615933.2 Postmitotic nuclear pore complex (NPC) reformation PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 97%112308 Presynaptic depolarization and calcium channel opening DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8863795 Downregulation of ERBB2 signaling INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex REGULATION OF PTEN LOCALIZATION%REACTOME%R-HSA-8948747.6 Regulation of PTEN localization NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 97%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.10 tRNA modification in the nucleus and cytosol FANCONI ANEMIA PATHWAY%REACTOME DATABASE ID RELEASE 97%6783310 Fanconi Anemia Pathway SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 97%69052 Switching of origins to a post-replicative state DEFECTIVE ABCC2 CAUSES DJS%REACTOME DATABASE ID RELEASE 97%5679001 Defective ABCC2 causes DJS CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.6 Chemokine receptors bind chemokines FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9762293 Regulation of CDH11 gene transcription DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME DATABASE ID RELEASE 97%5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 97%194315 Signaling by Rho GTPases CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 97%379401 Clearance of dopamine HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375281 Hormone ligand-binding receptors NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.5 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 97%5578997 Defective AHCY causes HMAHCHD LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 97%2980766 Nuclear Envelope Breakdown SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 97%1295596 Spry regulation of FGF signaling ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 97%1852241 Organelle biogenesis and maintenance CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 97%9943962 CHD6, CHD7, CHD8, CHD9 subfamily NUCLEOTIDE BIOSYNTHESIS%REACTOME%R-HSA-8956320.4 Nucleotide biosynthesis G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 97%389359 CD28 dependent Vav1 pathway VIRUS ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 97%168268 Virus Assembly and Release HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.8 Hyaluronan degradation CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960519.1 CASP4-mediated substrate cleavage DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 97%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME%R-HSA-202433.5 Generation of second messenger molecules ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769743 Amplification and propagation of coagulation cascade NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME%R-HSA-198725.4 Nuclear Events (kinase and transcription factor activation) TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 EICOSANOIDS%REACTOME%R-HSA-211979.3 Eicosanoids TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 97%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.4 Proton oligopeptide cotransporters IRS ACTIVATION%REACTOME DATABASE ID RELEASE 97%74713 IRS activation INTESTINAL HEXOSE ABSORPTION%REACTOME%R-HSA-8981373.2 Intestinal hexose absorption GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 97%8982491 Glycogen metabolism MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a AFFINITY SELECTION OF IMMUNOGLOBULINS%REACTOME DATABASE ID RELEASE 97%9938027 Affinity selection of immunoglobulins DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME DATABASE ID RELEASE 97%5678520 Defective ABCB11 causes PFIC2 and BRIC2 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 97%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME DATABASE ID RELEASE 97%5250968 Toxicity of botulinum toxin type A (botA) SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9663891 Selective autophagy CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013418 RHOBTB2 GTPase cycle LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 97%3656534 Loss of Function of TGFBR1 in Cancer REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.3 Regulation by c-FLIP CHYLOMICRON REMODELING%REACTOME DATABASE ID RELEASE 97%8963901 Chylomicron remodeling DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) NUCLEAR IMPORT OF REV PROTEIN%REACTOME DATABASE ID RELEASE 97%180746 Nuclear import of Rev protein PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72163 pre-mRNA splicing EGFR DOWNREGULATION%REACTOME DATABASE ID RELEASE 97%182971 EGFR downregulation TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME DATABASE ID RELEASE 97%9854909 Regulation of MITF-M dependent genes involved in invasion DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME%R-HSA-937061.5 TRIF (TICAM1)-mediated TLR4 signaling DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME DATABASE ID RELEASE 97%5678895 Defective CFTR causes cystic fibrosis CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.3 Manipulation of host energy metabolism ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME DATABASE ID RELEASE 97%9956520 ASS1 variants cause citrullinemia DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 97%606279 Deposition of new CENPA-containing nucleosomes at the centromere FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.3 FCGR3A-mediated IL10 synthesis DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME%R-HSA-3560796.4 Defective PAPSS2 causes SEMD-PA UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants REGULATION OF IFNA IFNB SIGNALING%REACTOME%R-HSA-912694.3 Regulation of IFNA IFNB signaling REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 97%428542 Regulation of commissural axon pathfinding by SLIT and ROBO TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 97%416993 Trafficking of GluR2-containing AMPA receptors AURKA ACTIVATION BY TPX2%REACTOME DATABASE ID RELEASE 97%8854518 AURKA Activation by TPX2 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 97%5250958 Toxicity of botulinum toxin type B (botB) TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 97%4549349 Defective ALG2 causes CDG-1i DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 97%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428559 Proton-coupled neutral amino acid transporters PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME%R-HSA-5576894.4 Phase 1 - inactivation of fast Na+ channels RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.6 RHO GTPase Effectors COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.8 Costimulation by the CD28 family SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.5 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5668541.5 TNFR2 non-canonical NF-kB pathway REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%R-HSA-211733.3 Regulation of activated PAK-2p34 by proteasome mediated degradation REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME%R-HSA-5686938.6 Regulation of TLR by endogenous ligand BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447041 CHL1 interactions TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 97%187042 TRKA activation by NGF CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 97%8874211 CREB3 factors activate genes SLC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 97%5619102 SLC transporter disorders SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.3 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 97%380612 Metabolism of serotonin SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME DATABASE ID RELEASE 97%9668328 Sealing of the nuclear envelope (NE) by ESCRT-III DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME DATABASE ID RELEASE 97%3656234 Defective HEXA causes GM2-gangliosidosis 1 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 97%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME DATABASE ID RELEASE 97%964827 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.6 Signaling by NOTCH1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME DATABASE ID RELEASE 97%9854311 Maturation of TCA enzymes and regulation of TCA cycle NUCLEOTIDE SALVAGE DEFECTS%REACTOME DATABASE ID RELEASE 97%9734207 Nucleotide salvage defects PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167290 Pausing and recovery of HIV elongation RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME DATABASE ID RELEASE 97%8985801 Regulation of cortical dendrite branching SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9031628 NGF-stimulated transcription PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 97%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME DATABASE ID RELEASE 97%9763198 Impaired BRCA2 binding to SEM1 (DSS1) MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 97%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) RHOB GTPASE CYCLE%REACTOME%R-HSA-9013026.2 RHOB GTPase cycle REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 97%912631 Regulation of signaling by CBL BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%8851680 Butyrophilin (BTN) family interactions DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 97%68952 DNA replication initiation IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 97%5603029 IkBA variant leads to EDA-ID REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.9 Regulation of necroptotic cell death INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5674499.2 Negative feedback regulation of MAPK pathway INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME DATABASE ID RELEASE 97%74751 Insulin receptor signalling cascade LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 97%380284 Loss of proteins required for interphase microtubule organization from the centrosome VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9026527 Activated NTRK2 signals through PLCG1 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 97%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654710 PI-3K cascade:FGFR3 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME%R-HSA-196843.4 Vitamin B2 (riboflavin) metabolism TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain ABACAVIR METABOLISM%REACTOME DATABASE ID RELEASE 97%2161541 Abacavir metabolism DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 97%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.4 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 97%8984722 Interleukin-35 Signalling INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.4 InlA-mediated entry of Listeria monocytogenes into host cells DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME DATABASE ID RELEASE 97%9661069 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022854 Keratan sulfate biosynthesis Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013422 RHOBTB1 GTPase cycle ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.5 Orc1 removal from chromatin RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111931.3 PKA-mediated phosphorylation of CREB REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8941858.3 Regulation of RUNX3 expression and activity CELLULAR RESPONSES TO STIMULI%REACTOME DATABASE ID RELEASE 97%8953897 Cellular responses to stimuli ASPIRIN ADME%REACTOME DATABASE ID RELEASE 97%9749641 Aspirin ADME PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%9931512 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655253 Signaling by FGFR2 in disease SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 97%2467813 Separation of Sister Chromatids HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME%R-HSA-3371497.7 HSP90 chaperone cycle for SHRs RMTS METHYLATE HISTONE ARGININES%REACTOME DATABASE ID RELEASE 97%3214858 RMTs methylate histone arginines ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169092 Activation of RAS in B cells APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.3 Apoptotic cleavage of cell adhesion proteins DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-5693606.6 DNA Double Strand Break Response CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME DATABASE ID RELEASE 97%5607763 CLEC7A (Dectin-1) induces NFAT activation INTESTINAL LIPID ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963678 Intestinal lipid absorption ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.6 Activation of caspases through apoptosome-mediated cleavage CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 97%5218900 CASP8 activity is inhibited DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 97%69416 Dimerization of procaspase-8 PLATELET CALCIUM HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418360 Platelet calcium homeostasis SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 97%9793242 SUMOylation of nuclear envelope proteins GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME%R-HSA-9820960.2 Respiratory syncytial virus (RSV) attachment and entry MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.4 mRNA decay by 5' to 3' exoribonuclease RAS GTPASE CYCLE MUTANTS%REACTOME DATABASE ID RELEASE 97%9649913 RAS GTPase cycle mutants RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 97%5627123 RHO GTPases activate PAKs DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 97%3359473 Defective MMADHC causes MMAHCD CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME DATABASE ID RELEASE 97%9664424 Cell recruitment (pro-inflammatory response) SYNTHESIS OF PA%REACTOME%R-HSA-1483166.8 Synthesis of PA CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 97%380287 Centrosome maturation FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.3 Metabolism of ingested SeMet, Sec, MeSec into H2Se ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 97%187015 Activation of TRKA receptors TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9703009.2 tamatinib-resistant FLT3 mutants METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 97%6806664 Metabolism of vitamin K RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME%R-HSA-9665245.2 Resistance of ERBB2 KD mutants to tesevatinib MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 97%9022699 MECP2 regulates neuronal receptors and channels DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 97%5579020 Defective SLC35D1 causes SCHBCKD SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 97%192105 Synthesis of bile acids and bile salts STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 97%211736 Stimulation of the cell death response by PAK-2p34 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 97%1299316 TWIK-releated acid-sensitive K+ channel (TASK) MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.4 Mtb iron assimilation by chelation DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 97%5654687 Downstream signaling of activated FGFR1 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 97%2243919 Crosslinking of collagen fibrils PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME%R-HSA-1855196.3 IP3 and IP4 transport between cytosol and nucleus SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 97%69239 Synthesis of DNA ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME%R-HSA-5625886.3 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME DATABASE ID RELEASE 97%190827 Transport of connexins along the secretory pathway DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 97%5579032 Defective TBXAS1 causes GHDD P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis INTERLEUKIN-21 SIGNALING%REACTOME%R-HSA-9020958.3 Interleukin-21 signaling NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373753 Nephrin family interactions FORMATION OF THE URETERIC BUD%REACTOME%R-HSA-9830674.1 Formation of the ureteric bud BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.5 Synthesis, secretion, and deacylation of Ghrelin NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 97%8849474 PTK6 Activates STAT3 ESSENTIAL FRUCTOSURIA%REACTOME%R-HSA-5657562.5 Essential fructosuria LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 97%9664535 LTC4-CYSLTR mediated IL4 production MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 97%9918432 Maturation of DENV proteins AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%1428517 Aerobic respiration and respiratory electron transport DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia THE IPAF INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844623 The IPAF inflammasome XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.5 XBP1(S) activates chaperone genes TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.6 Toll Like Receptor 3 (TLR3) Cascade ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME DATABASE ID RELEASE 97%8963889 Assembly of active LPL and LIPC lipase complexes DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 97%4720454 Defective ALG9 causes CDG-1l DISEASES OF BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%9605308 Diseases of Base Excision Repair DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 97%5690338 Defective ABCC6 causes PXE NILOTINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669926.2 Nilotinib-resistant KIT mutants PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654720 PI-3K cascade:FGFR4 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination SERINE METABOLISM%REACTOME%R-HSA-977347.9 Serine metabolism G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 97%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 97%1839122 Signaling by activated point mutants of FGFR1 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1592230 Mitochondrial biogenesis RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME DATABASE ID RELEASE 97%198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME DATABASE ID RELEASE 97%5576886 Phase 4 - resting membrane potential DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME%R-HSA-3371599.4 Defective HLCS causes multiple carboxylase deficiency DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918449 Defective visual phototransduction due to STRA6 loss of function FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.4 FMO oxidises nucleophiles VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.6 Presynaptic phase of homologous DNA pairing and strand exchange CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME%R-HSA-211897.6 Cytochrome P450 - arranged by substrate type SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662360 Sensory processing of sound by inner hair cells of the cochlea GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME DATABASE ID RELEASE 97%9726842 Gain-of-function MRAS complexes activate RAF signaling BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 97%2142700 Biosynthesis of Lipoxins (LX) PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME DATABASE ID RELEASE 97%4043911 Defective PMM2 causes CDG-1a CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.14 Carbohydrate metabolism DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants ERROR-RONE BASE EXCISION REPAIR (BER) HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME DATABASE ID RELEASE 97%9968297 Error-rone base excision repair (BER) hypermutates immunoglobulin genes TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME DATABASE ID RELEASE 97%1362277 Transcription of E2F targets under negative control by DREAM complex DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 97%3359475 Defective MMAA causes MMA, cblA type QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702620.2 quizartinib-resistant FLT3 mutants MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME%R-HSA-1614603.4 Cysteine formation from homocysteine GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation LDL REMODELING%REACTOME DATABASE ID RELEASE 97%8964041 LDL remodeling FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME%R-HSA-9706374.2 FLT3 signaling through SRC family kinases RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 97%110314 Recognition of DNA damage by PCNA-containing replication complex APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176409.5 APC C:Cdc20 mediated degradation of mitotic proteins COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 97%8948216 Collagen chain trimerization INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 97%499943 Interconversion of nucleotide di- and triphosphates MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112399 IRS-mediated signalling NICOTINATE METABOLISM%REACTOME DATABASE ID RELEASE 97%196807 Nicotinate metabolism LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 97%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions CELL-CELL COMMUNICATION%REACTOME DATABASE ID RELEASE 97%1500931 Cell-Cell communication DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME DATABASE ID RELEASE 97%9662001 Defective factor VIII causes hemophilia A DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 97%3781860 Diseases associated with N-glycosylation of proteins RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 97%5625970 RHO GTPases activate KTN1 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME DATABASE ID RELEASE 97%5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 97%9709570 Impaired BRCA2 binding to RAD51 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%192814 vRNA Synthesis BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620922 BBSome-mediated cargo-targeting to cilium RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 97%5663213 RHO GTPases Activate WASPs and WAVEs HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 97%9610379 HCMV Late Events SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4615885 SUMOylation of DNA replication proteins DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD CARDIOGENESIS%REACTOME%R-HSA-9733709.1 Cardiogenesis TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 97%4724325 Defective ALG8 causes CDG-1h DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME%R-HSA-5579013.4 Defective CYP7B1 causes SPG5A and CBAS3 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.3 Oligomerization of connexins into connexons DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 97%69002 DNA Replication Pre-Initiation HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 97%3371571 HSF1-dependent transactivation TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 97%9694635 Translation of Structural Proteins ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME%R-HSA-9682706.5 Replication of the SARS-CoV-1 genome SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853333 Signaling by FGFR2 fusions LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 SIGNALING BY MAP2K MUTANTS%REACTOME DATABASE ID RELEASE 97%9652169 Signaling by MAP2K mutants DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME DATABASE ID RELEASE 97%9735763 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine CHD1 AND CHD2 SUBFAMILY%REACTOME%R-HSA-9943411.1 CHD1 and CHD2 subfamily SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 97%917937 Iron uptake and transport TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 97%5624138 Trafficking of myristoylated proteins to the cilium TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME%R-HSA-8866911.3 TFAP2 (AP-2) family regulates transcription of cell cycle factors TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 97%933542 TRAF6 mediated NF-kB activation CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME DATABASE ID RELEASE 97%174184 Cdc20:Phospho-APC C mediated degradation of Cyclin A RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013406 RHOQ GTPase cycle RNA POLYMERASE II TRANSCRIPTION%REACTOME%R-HSA-73857.7 RNA Polymerase II Transcription STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation APAP ADME%REACTOME DATABASE ID RELEASE 97%9753281 APAP ADME HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 97%5658034 HHAT G278V doesn't palmitoylate Hh-Np TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts MPS IIIB - SANFILIPPO SYNDROME B%REACTOME DATABASE ID RELEASE 97%2206282 MPS IIIB - Sanfilippo syndrome B TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME DATABASE ID RELEASE 97%69895 Transcriptional activation of cell cycle inhibitor p21 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.3 Formation of Senescence-Associated Heterochromatin Foci (SAHF) SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME DATABASE ID RELEASE 97%174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME%R-HSA-9616333.3 Defective Base Excision Repair Associated with NTHL1 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME%R-HSA-9845621.1 Defective VWF cleavage by ADAMTS13 variant CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%389356 CD28 co-stimulation SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.5 Selenocysteine synthesis RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-9637690.3 Response of Mtb to phagocytosis MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 97%2214320 Anchoring fibril formation RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013409 RHOJ GTPase cycle STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 97%69541 Stabilization of p53 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%6784531 tRNA processing in the nucleus NCAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%419037 NCAM1 interactions PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 97%5654228 Phospholipase C-mediated cascade; FGFR4 INSULIN RECEPTOR RECYCLING%REACTOME%R-HSA-77387.6 Insulin receptor recycling DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 97%5654716 Downstream signaling of activated FGFR4 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.2 RUNX1 regulates transcription of genes involved in WNT signaling TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME%R-HSA-6787450.10 tRNA modification in the mitochondrion REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9818749 Regulation of NFE2L2 gene expression DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734195 Defective APRT disrupts adenine salvage MIRO GTPASE CYCLE%REACTOME%R-HSA-9715370.3 Miro GTPase Cycle COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 97%204005 COPII-mediated vesicle transport MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 97%8849470 PTK6 Regulates Cell Cycle TELOMERE EXTENSION BY TELOMERASE%REACTOME%R-HSA-171319.5 Telomere Extension By Telomerase MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) DEFECTIVE CYP17A1 CAUSES AH5%REACTOME%R-HSA-5579028.6 Defective CYP17A1 causes AH5 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 97%1614517 Sulfide oxidation to sulfate ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.7 Sphingolipid metabolism DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 97%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) AXON GUIDANCE%REACTOME%R-HSA-422475.8 Axon guidance SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.5 Extracellular matrix organization CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.4 Toll Like Receptor 4 (TLR4) Cascade BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 97%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.5 Phospholipid metabolism REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 97%9821993 Replacement of protamines by nucleosomes in the male pronucleus DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9918440 Defective visual phototransduction due to RDH12 loss of function IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 97%1296053 Classical Kir channels DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 97%5579027 Defective CYP27B1 causes VDDR1B MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602566 TICAM1 deficiency - HSE DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.2 Aggregated β-amyloid induces FXII autocatalysis SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559585 Oncogene Induced Senescence ROBO RECEPTORS BIND AKAP5%REACTOME%R-HSA-9010642.2 ROBO receptors bind AKAP5 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME%R-HSA-9665249.2 Resistance of ERBB2 KD mutants to afatinib DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.2 Dasatinib-resistant KIT mutants DISEASES OF GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%3781865 Diseases of glycosylation INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME%R-HSA-9636249.2 Inhibition of nitric oxide production MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 97%9694301 Maturation of replicase proteins DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 97%75205 Dissolution of Fibrin Clot COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811436 COPI-independent Golgi-to-ER retrograde traffic LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME%R-HSA-9031525.2 LXRs regulate gene expression to limit cholesterol uptake REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME%R-HSA-9764562.1 Regulation of CDH1 mRNA translation by microRNAs DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 97%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-HSA-8963693.6 Aspartate and asparagine metabolism FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME%R-HSA-5675221.6 Negative regulation of MAPK pathway SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells DISEASES OF THE UREA CYCLE%REACTOME DATABASE ID RELEASE 97%9955698 Diseases of the urea cycle SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME DATABASE ID RELEASE 97%5083625 Defective GALNT3 causes HFTC MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339700 Signaling by TCF7L2 mutants ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 97%1280218 Adaptive Immune System BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins OVARIAN TUMOR DOMAIN PROTEASES%REACTOME%R-HSA-5689896.5 Ovarian tumor domain proteases INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.4 Initial triggering of complement MUSCLE CONTRACTION%REACTOME%R-HSA-397014.6 Muscle contraction SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 97%166520 Signaling by NTRKs SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9735869.2 SARS-CoV-1 modulates host translation machinery CA-DEPENDENT EVENTS%REACTOME%R-HSA-111996.3 Ca-dependent events AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375280 Amine ligand-binding receptors FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME%R-HSA-9823739.2 Formation of the anterior neural plate DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor HOST INTERACTIONS OF HIV FACTORS%REACTOME DATABASE ID RELEASE 97%162909 Host Interactions of HIV factors MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME%R-HSA-5210891.4 Uptake and function of anthrax toxins CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME%R-HSA-111461.5 Cytochrome c-mediated apoptotic response DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704646 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764790 Positive Regulation of CDH1 Gene Transcription SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME DATABASE ID RELEASE 97%9840373 Cellular response to mitochondrial stress DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME%R-HSA-5579030.4 Defective CYP19A1 causes AEXS PRPP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%73843 PRPP biosynthesis RSK ACTIVATION%REACTOME DATABASE ID RELEASE 97%444257 RSK activation EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 97%3928662 EPHB-mediated forward signaling MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.3 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME%R-HSA-9690406.3 Transcriptional regulation of testis differentiation BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME%R-HSA-9661070.2 Defective translocation of RB1 mutants to the nucleus CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 97%8949613 Cristae formation IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME%R-HSA-937041.3 IKK complex recruitment mediated by RIP1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME DATABASE ID RELEASE 97%175567 Integration of viral DNA into host genomic DNA DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 97%9918485 Dengue Virus Attachment and Entry RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 97%5362798 Release of Hh-Np from the secreting cell APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME%R-HSA-9819196.1 Zygotic genome activation (ZGA) TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%381340 Transcriptional regulation of white adipocyte differentiation ALANINE METABOLISM%REACTOME%R-HSA-8964540.4 Alanine metabolism TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME%R-HSA-9846298.1 Defective binding of VWF variant to GPIb:IX:V TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 97%111469 SMAC, XIAP-regulated apoptotic response THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2514856 The phototransduction cascade BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 97%9024909 BDNF activates NTRK2 (TRKB) signaling MPS IIIC - SANFILIPPO SYNDROME C%REACTOME DATABASE ID RELEASE 97%2206291 MPS IIIC - Sanfilippo syndrome C RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection IMMUNE SYSTEM%REACTOME%R-HSA-168256.9 Immune System SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69613 p53-Independent G1 S DNA Damage Checkpoint IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 97%2644603 Signaling by NOTCH1 in Cancer COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 97%1650814 Collagen biosynthesis and modifying enzymes INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696395 Formation of Incision Complex in GG-NER TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME%R-HSA-5357956.5 TNFR1-induced NF-kappa-B signaling pathway GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.5 Glutamate binding, activation of AMPA receptors and synaptic plasticity TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 97%1299361 TWIK-related alkaline pH activated K+ channel (TALK) BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME%R-HSA-9859138.1 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 97%888590 GABA synthesis, release, reuptake and degradation PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.4 PI and PC transport between ER and Golgi membranes INTRACELLULAR OXYGEN TRANSPORT%REACTOME DATABASE ID RELEASE 97%8981607 Intracellular oxygen transport DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9699150 Defective DNA double strand break response due to BARD1 loss of function BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 97%69166 Removal of the Flap Intermediate DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.3 CLEC7A (Dectin-1) signaling RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 97%112126 ALKBH3 mediated reversal of alkylation damage RAC2 GTPASE CYCLE%REACTOME%R-HSA-9013404.2 RAC2 GTPase cycle TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME%R-HSA-9634815.4 Transcriptional Regulation by NPAS4 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190872.3 Transport of connexons to the plasma membrane CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME%R-HSA-156584.8 Cytosolic sulfonation of small molecules SARS-COV-2-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9705683 SARS-CoV-2-host interactions MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 97%5545483 Defective Mismatch Repair Associated With MLH1 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME%R-HSA-141333.6 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 97%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 PROTEIN LIPOYLATION%REACTOME DATABASE ID RELEASE 97%9857492 Protein lipoylation ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 97%392023 Adrenaline signalling through Alpha-2 adrenergic receptor DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9920951 Dengue virus modulates apoptosis DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.7 Diseases of hemostasis TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 97%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer DISEASES OF METABOLISM%REACTOME DATABASE ID RELEASE 97%5668914 Diseases of metabolism SIGNALLING TO RAS%REACTOME%R-HSA-167044.6 Signalling to RAS CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 97%159424 Conjugation of carboxylic acids POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 97%163125 Post-translational modification: synthesis of GPI-anchored proteins DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.4 Defective MAOA causes BRUNS SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME DATABASE ID RELEASE 97%418038 Nucleotide-like (purinergic) receptors NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 97%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%8940973 RUNX2 regulates osteoblast differentiation SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 97%1799339 SRP-dependent cotranslational protein targeting to membrane HCMV INFECTION%REACTOME%R-HSA-9609646.5 HCMV Infection MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 97%2129379 Molecules associated with elastic fibres ACETYLATION%REACTOME%R-HSA-156582.4 Acetylation REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation PURINE CATABOLISM%REACTOME%R-HSA-74259.8 Purine catabolism MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.3 Metabolism of ingested MeSeO2H into MeSeH TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME DATABASE ID RELEASE 97%174430 Telomere C-strand synthesis initiation O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%5173105 O-linked glycosylation POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.2 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME%R-HSA-5610780.2 Degradation of GLI1 by the proteasome RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 97%429947 Deadenylation of mRNA DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME DATABASE ID RELEASE 97%4549380 Defective ALG1 causes CDG-1k HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.4 Hyaluronan metabolism IMMUNOGLOBULIN MATURATION%REACTOME%R-HSA-9938026.1 Immunoglobulin maturation BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447038 NrCAM interactions RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade METAL ION ASSIMILATION FROM THE HOST%REACTOME%R-HSA-9638482.1 Metal ion assimilation from the host NEUROTRANSMITTER CLEARANCE%REACTOME%R-HSA-112311.7 Neurotransmitter clearance GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME%R-HSA-162658.3 Golgi Cisternae Pericentriolar Stack Reorganization INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 97%446652 Interleukin-1 family signaling SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%3232118 SUMOylation of transcription factors ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 97%9956514 ARG1 variants cause hyperargininemia DEFECTIVE CD320 CAUSES MMATC%REACTOME%R-HSA-3359485.4 Defective CD320 causes MMATC MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 97%68877 Mitotic Prometaphase NGF PROCESSING%REACTOME DATABASE ID RELEASE 97%167060 NGF processing GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1971475 Glycosaminoglycan-protein linkage region biosynthesis C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME DATABASE ID RELEASE 97%9954714 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME%R-HSA-8939247.2 RUNX1 regulates transcription of genes involved in interleukin signaling UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME DATABASE ID RELEASE 97%9758881 Uptake of dietary cobalamins into enterocytes DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.5 Defective GGT1 causes GLUTH BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors RECYCLING OF BILE ACIDS AND SALTS%REACTOME%R-HSA-159418.6 Recycling of bile acids and salts SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 97%190236 Signaling by FGFR TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467348 Truncations of AMER1 destabilize the destruction complex REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 97%73943 Reversal of alkylation damage by DNA dioxygenases TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME%R-HSA-5669034.4 TNFs bind their physiological receptors SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 97%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME DATABASE ID RELEASE 97%8853336 Signaling by plasma membrane FGFR1 fusions CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME DATABASE ID RELEASE 97%453279 Mitotic G1 phase and G1 S transition PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 97%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF FORMATION OF THE NEPHRIC DUCT%REACTOME%R-HSA-9830364.1 Formation of the nephric duct PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME%R-HSA-9861559.1 PDH complex synthesizes acetyl-CoA from PYR FGFR2 ALTERNATIVE SPLICING%REACTOME DATABASE ID RELEASE 97%6803529 FGFR2 alternative splicing DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9920588.1 Dengue virus activates modulates innate and adaptive immune responses NONSENSE-MEDIATED DECAY (NMD)%REACTOME%R-HSA-927802.4 Nonsense-Mediated Decay (NMD) METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 97%8978934 Metabolism of cofactors NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654732 Negative regulation of FGFR3 signaling MRNA CAPPING%REACTOME DATABASE ID RELEASE 97%72086 mRNA Capping DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 97%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-HSA-1660499.8 Synthesis of PIPs at the plasma membrane DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 97%4570571 Defective RFT1 causes CDG-1n DEFECTIVE OGG1 LOCALIZATION%REACTOME%R-HSA-9657050.2 Defective OGG1 Localization DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 97%3296482 Defects in vitamin and cofactor metabolism INFLUENZA INFECTION%REACTOME%R-HSA-168255.6 Influenza Infection UNC93B1 DEFICIENCY - HSE%REACTOME%R-HSA-5602415.3 UNC93B1 deficiency - HSE EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME%R-HSA-9931509.1 Expression of BMAL (ARNTL), CLOCK, and NPAS2 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69481 G2 M Checkpoints INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 97%9014826 Interleukin-36 pathway M PHASE%REACTOME DATABASE ID RELEASE 97%68886 M Phase VOLTAGE GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296072 Voltage gated Potassium channels MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 97%912446 Meiotic recombination SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 97%480985 Synthesis of dolichyl-phosphate-glucose FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME DATABASE ID RELEASE 97%9933947 Formation of the non-canonical BAF (ncBAF) complex SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 97%9726840 SHOC2 M1731 mutant abolishes MRAS complex function MATURATION OF HRSV A PROTEINS%REACTOME%R-HSA-9828806.1 Maturation of hRSV A proteins INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 97%8963676 Intestinal absorption TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 97%442755 Activation of NMDA receptors and postsynaptic events GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME%R-HSA-8950505.5 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 97%164940 Nef mediated downregulation of MHC class I complex cell surface expression SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 97%4839744 Signaling by APC mutants ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME DATABASE ID RELEASE 97%9667769 Acetylcholine inhibits contraction of outer hair cells RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 97%611105 Respiratory electron transport HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.5 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation MDK AND PTN IN ALK SIGNALING%REACTOME DATABASE ID RELEASE 97%9851151 MDK and PTN in ALK signaling SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME DATABASE ID RELEASE 97%6802952 Signaling by BRAF and RAF1 fusions SIGNALING BY RNF43 MUTANTS%REACTOME DATABASE ID RELEASE 97%5340588 Signaling by RNF43 mutants CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 97%442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 97%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 97%2395516 Electron transport from NADPH to Ferredoxin ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 97%1606322 ZBP1(DAI) mediated induction of type I IFNs REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9824594 Regulation of MITF-M-dependent genes involved in apoptosis STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME%R-HSA-9702518.2 STAT5 activation downstream of FLT3 ITD mutants PKMTS METHYLATE HISTONE LYSINES%REACTOME%R-HSA-3214841.5 PKMTs methylate histone lysines DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME%R-HSA-9938206.2 Developmental Lineage of Mammary Stem Cells LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 97%432720 Lysosome Vesicle Biogenesis RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037628.2 Rhesus blood group biosynthesis CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.3 Conjugation of benzoate with glycine CA2+ PATHWAY%REACTOME DATABASE ID RELEASE 97%4086398 Ca2+ pathway B CELL ACTIVATION%REACTOME%R-HSA-983705.3 B Cell Activation SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 97%8851708 Signaling by FGFR2 IIIa TM REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296346 Tandem pore domain potassium channels MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 97%420029 Tight junction interactions CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.9 RHO GTPases Activate NADPH Oxidases VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.4 VEGFR2 mediated vascular permeability BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME DATABASE ID RELEASE 97%446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.9 Fructose catabolism ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 97%3371568 Attenuation phase DAG1 CORE M3 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932505 DAG1 core M3 glycosylations DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 97%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination ASSEMBLY OF THE 9+2 MOTILE CILIA%REACTOME DATABASE ID RELEASE 97%9975924 Assembly of the 9+2 motile cilia DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME DATABASE ID RELEASE 97%9927426 Developmental Lineage of Mammary Gland Alveolar Cells FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 97%9617828 FOXO-mediated transcription of cell cycle genes SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks SYNTHESIS OF PE%REACTOME%R-HSA-1483213.5 Synthesis of PE INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 97%111463 SMAC (DIABLO) binds to IAPs ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2468052 Establishment of Sister Chromatid Cohesion FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654700 FRS-mediated FGFR2 signaling TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME%R-HSA-72202.4 Transport of Mature Transcript to Cytoplasm RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME%R-HSA-9648895.4 Response of EIF2AK1 (HRI) to heme deficiency VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME DATABASE ID RELEASE 97%180910 Vpr-mediated nuclear import of PICs MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.2 Masitinib-resistant KIT mutants PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.5 Phase 0 - rapid depolarisation NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9026357.2 NTF4 activates NTRK2 (TRKB) signaling DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME DATABASE ID RELEASE 97%9672383 Defective factor IX causes thrombophilia MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 97%73772 RNA Polymerase I Promoter Escape EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects IRAK1 RECRUITS IKK COMPLEX%REACTOME%R-HSA-937039.3 IRAK1 recruits IKK complex CHD CHROMATIN REMODELERS%REACTOME%R-HSA-9937848.1 CHD chromatin remodelers SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma HYDROLYSIS OF LPC%REACTOME%R-HSA-1483115.5 Hydrolysis of LPC LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.2 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME DATABASE ID RELEASE 97%9909615 Regulation of PD-L1(CD274) Post-translational modification SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME%R-HSA-416550.4 Sema4D mediated inhibition of cell attachment and migration ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9028335 Activated NTRK2 signals through PI3K INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013420 RHOU GTPase cycle ION HOMEOSTASIS%REACTOME%R-HSA-5578775.4 Ion homeostasis MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953078.1 MPS II - Hunter syndrome (CS DS degradation) MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 97%936440 Negative regulators of RIG-I MDA5 signaling FIBRIN FORMATION%REACTOME%R-HSA-9769733.1 Fibrin formation PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022870 CS-GAG biosynthesis DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 97%9659787 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 97%2142770 Synthesis of 15-eicosatetraenoic acid derivatives GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.7 GPVI-mediated activation cascade CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%420499 Class C 3 (Metabotropic glutamate pheromone receptors) GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME%R-HSA-157858.3 Gap junction trafficking and regulation ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68867.10 Assembly of the pre-replicative complex SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 97%167242 Abortive elongation of HIV-1 transcript in the absence of Tat EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 97%171007 p38MAPK events PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%3359454 Defective TCN2 causes TCN2 deficiency STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%9913635 Strand-asynchronous mitochondrial DNA replication VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs ALECTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717316 alectinib-resistant ALK mutants CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME DATABASE ID RELEASE 97%1834949 Cytosolic sensors of pathogen-associated DNA PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%500657 Presynaptic function of Kainate receptors ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.5 Activation of BH3-only proteins NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 97%9032759 NTRK2 activates RAC1 SCN4%REACTOME DATABASE ID RELEASE 97%3282872 SCN4 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 97%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 TRANSLATION%REACTOME DATABASE ID RELEASE 97%72766 Translation NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 97%9818026 NFE2L2 regulating inflammation associated genes PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702614.2 ponatinib-resistant FLT3 mutants ONCOGENIC MAPK SIGNALING%REACTOME DATABASE ID RELEASE 97%6802957 Oncogenic MAPK signaling SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME DATABASE ID RELEASE 97%5619088 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME%R-HSA-9818025.2 NFE2L2 regulating TCA cycle genes SIGNALING BY ACTIVIN%REACTOME DATABASE ID RELEASE 97%1502540 Signaling by Activin LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304347 Loss of Function of SMAD4 in Cancer BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%173107 Binding and entry of HIV virion YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-9020558.5 Interleukin-2 signaling DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 97%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME DATABASE ID RELEASE 97%5678771 Defective ABCB4 causes PFIC3, ICP3 and GBD1 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3311021.3 SMAD4 MH2 Domain Mutants in Cancer DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells SIGNALING BY RAS GAP MUTANTS%REACTOME DATABASE ID RELEASE 97%9753510 Signaling by RAS GAP mutants DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 97%420597 Nectin Necl trans heterodimerization ECM PROTEOGLYCANS%REACTOME DATABASE ID RELEASE 97%3000178 ECM proteoglycans DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME DATABASE ID RELEASE 97%5619052 Defective SLC9A9 causes autism 16 (AUTS16) VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 97%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856825.5 Cargo recognition for clathrin-mediated endocytosis MASTL FACILITATES MITOTIC PROGRESSION%REACTOME DATABASE ID RELEASE 97%2465910 MASTL Facilitates Mitotic Progression MITOCHONDRIAL RNA DEGRADATION%REACTOME DATABASE ID RELEASE 97%9836573 Mitochondrial RNA degradation PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%391908 Prostanoid ligand receptors DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%193993 Mineralocorticoid biosynthesis INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9730414 MITF-M-regulated melanocyte development TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9937080 Developmental Lineage of Multipotent Pancreatic Progenitor Cells SIGNALING BY LRP5 MUTANTS%REACTOME DATABASE ID RELEASE 97%5339717 Signaling by LRP5 mutants POTENTIAL THERAPEUTICS FOR SARS%REACTOME DATABASE ID RELEASE 97%9679191 Potential therapeutics for SARS ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 97%428540 Activation of RAC1 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9937850 NuRD complex assembly DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME%R-HSA-9665230.4 Drug resistance in ERBB2 KD mutants EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%72613 Eukaryotic Translation Initiation HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 97%5657560 Hereditary fructose intolerance NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME DATABASE ID RELEASE 97%9818028 NFE2L2 regulates pentose phosphate pathway genes TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 97%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.2 Blockage of phagosome acidification MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME%R-HSA-6791226.5 Major pathway of rRNA processing in the nucleolus and cytosol NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%373752 Netrin-1 signaling DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 97%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 97%8877627 Vitamin E transport MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702600.2 midostaurin-resistant FLT3 mutants CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 97%380259 Loss of Nlp from mitotic centrosomes EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 97%8941413 Events associated with phagocytolytic activity of PMN cells FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME%R-HSA-9832991.2 Formation of the posterior neural plate GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%373760 L1CAM interactions DRUG ADME%REACTOME DATABASE ID RELEASE 97%9748784 Drug ADME AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 97%1643713 Signaling by EGFR in Cancer LORLATINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717329.2 lorlatinib-resistant ALK mutants SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.6 Cell Cycle, Mitotic TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME%R-HSA-159227.4 Transport of the SLBP independent Mature mRNA DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-HSA-8849468.2 PTK6 Regulates Proteins Involved in RNA Processing SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 97%9006115 Signaling by NTRK2 (TRKB) CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 97%69017 CDK-mediated phosphorylation and removal of Cdc6 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 97%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME DATABASE ID RELEASE 97%446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 97%5685942 HDR through Homologous Recombination (HRR) EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME DATABASE ID RELEASE 97%9818564 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 97%180336 SHC1 events in EGFR signaling LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013149 RAC1 GTPase cycle WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%977068 Termination of O-glycan biosynthesis DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 97%445989 TAK1-dependent IKK and NF-kappa-B activation SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 97%9700206 Signaling by ALK in cancer DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 97%450282 MAPK targets Nuclear events mediated by MAP kinases RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription RHOD GTPASE CYCLE%REACTOME%R-HSA-9013405.5 RHOD GTPase cycle DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME%R-HSA-9717207.2 Sensory perception of sweet, bitter, and umami (glutamate) taste DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME DATABASE ID RELEASE 97%9842860 Regulation of endogenous retroelements FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190239.3 FGFR3 ligand binding and activation BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME%R-HSA-73929.5 Base-Excision Repair, AP Site Formation SIGNALING BY ROBO RECEPTORS%REACTOME%R-HSA-376176.7 Signaling by ROBO receptors DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 97%5423599 Diseases of Mismatch Repair (MMR) PENTOSE PHOSPHATE PATHWAY%REACTOME DATABASE ID RELEASE 97%71336 Pentose phosphate pathway TNF SIGNALING%REACTOME DATABASE ID RELEASE 97%75893 TNF signaling RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME%R-HSA-179409.5 APC-Cdc20 mediated degradation of Nek2A INACTIVATION OF CDC42 AND RAC1%REACTOME%R-HSA-428543.4 Inactivation of CDC42 and RAC1 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 97%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000171 Non-integrin membrane-ECM interactions REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME%R-HSA-2029482.4 Regulation of actin dynamics for phagocytic cup formation DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 97%5627117 RHO GTPases Activate ROCKs SDK INTERACTIONS%REACTOME%R-HSA-373756.3 SDK interactions REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654733 Negative regulation of FGFR4 signaling PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.5 Presynaptic nicotinic acetylcholine receptors LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.3 LXR-mediated signaling SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 97%187687 Signalling to ERKs EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 97%9036866 Expression and Processing of Neurotrophins HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 97%5685938 HDR through Single Strand Annealing (SSA) ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139910 Activation of BMF and translocation to mitochondria INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME%R-HSA-9635486.4 Infection with Mycobacterium tuberculosis TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 97%933541 TRAF6 mediated IRF7 activation COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 97%2470946 Cohesin Loading onto Chromatin MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 97%8875878 MET promotes cell motility METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME%R-HSA-6806667.9 Metabolism of fat-soluble vitamins MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 97%9856872 Malate-aspartate shuttle PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME DATABASE ID RELEASE 97%8850843 Phosphate bond hydrolysis by NTPDase proteins DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%8980692 RHOA GTPase cycle RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.4 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RHO GTPASES ACTIVATE PKNS%REACTOME%R-HSA-5625740.3 RHO GTPases activate PKNs LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 97%8964572 Lipid particle organization ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 97%1237044 Erythrocytes take up carbon dioxide and release oxygen GP1B-IX-V ACTIVATION SIGNALLING%REACTOME%R-HSA-430116.3 GP1b-IX-V activation signalling CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 97%9614657 FOXO-mediated transcription of cell death genes NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 97%209560 NF-kB is activated and signals survival NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME DATABASE ID RELEASE 97%9759194 Nuclear events mediated by NFE2L2 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins OAS ANTIVIRAL RESPONSE%REACTOME%R-HSA-8983711.5 OAS antiviral response VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 97%5620916 VxPx cargo-targeting to cilium SARS-COV-1 INFECTION%REACTOME%R-HSA-9678108.8 SARS-CoV-1 Infection GSD 0%REACTOME DATABASE ID RELEASE 97%3858516 GSD 0 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME DATABASE ID RELEASE 97%9825895 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME%R-HSA-9762114.3 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 KERATAN SULFATE KERATIN METABOLISM%REACTOME DATABASE ID RELEASE 97%1638074 Keratan sulfate keratin metabolism ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 97%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 97%2219530 Constitutive Signaling by Aberrant PI3K in Cancer RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 97%8876198 RAB GEFs exchange GTP for GDP on RABs EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 97%5632927 Defective Mismatch Repair Associated With MSH3 PTK6 EXPRESSION%REACTOME DATABASE ID RELEASE 97%8849473 PTK6 Expression RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 97%388844 Receptor-type tyrosine-protein phosphatases G2 M TRANSITION%REACTOME%R-HSA-69275.7 G2 M Transition TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.8 Transcription from mitochondrial promoters DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 97%73893 DNA Damage Bypass POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.5 Postsynaptic nicotinic acetylcholine receptors RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833110 RSV-host interactions SPERM MOTILITY AND TAXES%REACTOME%R-HSA-1300642.2 Sperm Motility And Taxes ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME DATABASE ID RELEASE 97%9958825 Activation of STAT3 by cadherin engagement DEFECTIVE F8 SULFATION AT Y1699%REACTOME DATABASE ID RELEASE 97%9674519 Defective F8 sulfation at Y1699 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling INTERLEUKIN-37 SIGNALING%REACTOME%R-HSA-9008059.4 Interleukin-37 signaling TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 97%8878159 Transcriptional regulation by RUNX3 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME DATABASE ID RELEASE 97%9931530 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex UREA CYCLE%REACTOME%R-HSA-70635.5 Urea cycle DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%774815 Nucleosome assembly ACYL CHAIN REMODELLING OF PE%REACTOME DATABASE ID RELEASE 97%1482839 Acyl chain remodelling of PE DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 97%1168372 Downstream signaling events of B Cell Receptor (BCR) SYNTHESIS OF PG%REACTOME%R-HSA-1483148.4 Synthesis of PG BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME DATABASE ID RELEASE 97%5619094 Variant SLC6A14 may confer susceptibility towards obesity METHYLATION%REACTOME%R-HSA-156581.6 Methylation ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 97%170984 ARMS-mediated activation EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 97%9630791 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 97%9694548 Maturation of spike protein MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME%R-HSA-9837999.2 Mitochondrial protein degradation SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME DATABASE ID RELEASE 97%9759785 Diseases of propionyl-CoA catabolism DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 97%5579019 Defective FMO3 causes TMAU MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade SIGNALING BY LTK IN CANCER%REACTOME%R-HSA-9842640.1 Signaling by LTK in cancer PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME%R-HSA-392170.5 ADP signalling through P2Y purinoceptor 12 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927432 Developmental Lineage of Mammary Gland Myoepithelial Cells GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) MHC CLASS II ANTIGEN PRESENTATION%REACTOME%R-HSA-2132295.5 MHC class II antigen presentation SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%8847453 Synthesis of PIPs in the nucleus FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME%R-HSA-77042.4 Formation of editosomes by ADAR proteins PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-HSA-392851.5 Prostacyclin signalling through prostacyclin receptor CDC42 GTPASE CYCLE%REACTOME%R-HSA-9013148.5 CDC42 GTPase cycle SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 97%9665686 Signaling by ERBB2 TMD JMD mutants CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.6 Cardiac conduction CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 97%2559583 Cellular Senescence HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 97%5693579 Homologous DNA Pairing and Strand Exchange SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME%R-HSA-1660514.5 Synthesis of PIPs at the Golgi membrane DEFECTIVE MTRR CAUSES HMAE%REACTOME%R-HSA-3359467.4 Defective MTRR causes HMAE MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 97%9632693 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 97%167246 Tat-mediated elongation of the HIV-1 transcript ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 97%9932444 ATP-dependent chromatin remodelers ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME DATABASE ID RELEASE 97%380972 Energy dependent regulation of mTOR by LKB1-AMPK VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5619101 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 97%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.3 Nucleotide salvage TRANSLESION SYNTHESIS BY POLI%REACTOME DATABASE ID RELEASE 97%5656121 Translesion synthesis by POLI AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME%R-HSA-198693.4 AKT phosphorylates targets in the nucleus DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 97%1489509 DAG and IP3 signaling LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%196108 Pregnenolone biosynthesis SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME%R-HSA-1855170.3 IPs transport between nucleus and cytosol CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME%R-HSA-1793185.4 Chondroitin sulfate dermatan sulfate metabolism INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME%R-HSA-6811442.2 Intra-Golgi and retrograde Golgi-to-ER traffic PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 97%6791465 Pentose phosphate pathway disease MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) SIGNALING BY PDGF%REACTOME%R-HSA-186797.6 Signaling by PDGF DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME DATABASE ID RELEASE 97%9734281 Defective HPRT1 disrupts guanine and hypoxanthine salvage DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 97%5632987 Defective Mismatch Repair Associated With PMS2 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.5 Serotonin Neurotransmitter Release Cycle APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 97%449836 Other interleukin signaling PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.6 Disassembly of the destruction complex and recruitment of AXIN to the membrane PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling LIPOPROTEIN METABOLISM%REACTOME DATABASE ID RELEASE 97%174824 Lipoprotein metabolism ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME%R-HSA-9032500.2 Activated NTRK2 signals through FYN RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE RRNA PROCESSING%REACTOME%R-HSA-72312.5 rRNA processing FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9970672.2 FXIIa activates plasma kallikrein-kinin system TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 97%159763 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism AGGREPHAGY%REACTOME DATABASE ID RELEASE 97%9646399 Aggrephagy SARS-COV INFECTIONS%REACTOME DATABASE ID RELEASE 97%9679506 SARS-CoV Infections SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME DATABASE ID RELEASE 97%3899300 SUMOylation of transcription cofactors SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163767 PP2A-mediated dephosphorylation of key metabolic factors DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding HIV TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%167161 HIV Transcription Initiation MPS IIIA - SANFILIPPO SYNDROME A%REACTOME%R-HSA-2206307.5 MPS IIIA - Sanfilippo syndrome A SIGNALING BY FLT3 FUSION PROTEINS%REACTOME%R-HSA-9703465.2 Signaling by FLT3 fusion proteins POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 97%3828062 GSD 0 (muscle) INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME DATABASE ID RELEASE 97%997272 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 97%9909396 Circadian clock FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 97%5579017 Defective CYP11B1 causes AH4 ACTIVATION OF GABAB RECEPTORS%REACTOME DATABASE ID RELEASE 97%991365 Activation of GABAB receptors CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 97%1234158 Regulation of gene expression by Hypoxia-inducible Factor C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 97%9936686 Aggregated β-amyloid interacts with fibrinogen PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 97%6811555 PI5P Regulates TP53 Acetylation BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 97%4641257 Degradation of AXIN DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 97%3560801 Defective B3GAT3 causes JDSSDHD DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 97%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance FLT3 SIGNALING%REACTOME%R-HSA-9607240.8 FLT3 Signaling LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME DATABASE ID RELEASE 97%9907570 Loss-of-function mutations in DLD cause MSUD3 DLDD DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME%R-HSA-9930449.1 Defective cleavage of FV variant at a.a.534 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 97%1234174 Cellular response to hypoxia DEFECTIVE DHDDS CAUSES RP59%REACTOME DATABASE ID RELEASE 97%4755609 Defective DHDDS causes RP59 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 97%9762292 Regulation of CDH11 function INTERFERON SIGNALING%REACTOME DATABASE ID RELEASE 97%913531 Interferon Signaling PEPTIDE CHAIN ELONGATION%REACTOME DATABASE ID RELEASE 97%156902 Peptide chain elongation DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%73942 DNA Damage Reversal SARS-COV-1-HOST INTERACTIONS%REACTOME%R-HSA-9692914.3 SARS-CoV-1-host interactions SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog CGMP EFFECTS%REACTOME%R-HSA-418457.3 cGMP effects PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection PROTEASOME ASSEMBLY%REACTOME%R-HSA-9907900.1 Proteasome assembly BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME%R-HSA-2173782.3 Binding and Uptake of Ligands by Scavenger Receptors LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944997 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome S PHASE%REACTOME DATABASE ID RELEASE 97%69242 S Phase ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME%R-HSA-114294.4 Activation, translocation and oligomerization of BAX PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%1170546 Prolactin receptor signaling CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME%R-HSA-389357.3 CD28 dependent PI3K Akt signaling POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%156711 Polo-like kinase mediated events HISTIDINE CATABOLISM%REACTOME%R-HSA-70921.7 Histidine catabolism SORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669936.2 Sorafenib-resistant KIT mutants UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME DATABASE ID RELEASE 97%5083632 Defective C1GALT1C1 causes TNPS PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 97%109703 PKB-mediated events ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 97%76002 Platelet activation, signaling and aggregation DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME DATABASE ID RELEASE 97%4720489 Defective ALG12 causes CDG-1g SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.4 Senescence-Associated Secretory Phenotype (SASP) PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 97%9005895 Pervasive developmental disorders STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 97%3249367 STAT6-mediated induction of chemokines FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190372 FGFR3c ligand binding and activation TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 97%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 97%8875513 MET interacts with TNS proteins SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 97%1483248 Synthesis of PIPs at the ER membrane PKR-MEDIATED SIGNALING%REACTOME%R-HSA-9833482.3 PKR-mediated signaling REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 97%9764302 Regulation of CDH19 Expression and Function EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 97%1433617 Regulation of signaling by NODAL DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 97%3359469 Defective MTR causes HMAG MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 97%433692 Proton-coupled monocarboxylate transport PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 97%432142 Platelet sensitization by LDL MRNA SPLICING%REACTOME DATABASE ID RELEASE 97%72172 mRNA Splicing ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME%R-HSA-379398.5 Enzymatic degradation of Dopamine by monoamine oxidase FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 97%9913351 Formation of the dystrophin-glycoprotein complex (DGC) ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis DEVELOPMENTAL LINEAGE OF PANCREATIC ENDOCRINE MID PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%9981148 Developmental Lineage of Pancreatic Endocrine Mid Progenitor Cells SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702632.2 sunitinib-resistant FLT3 mutants APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 COX REACTIONS%REACTOME%R-HSA-140180.4 COX reactions SHC-MEDIATED CASCADE:FGFR2%REACTOME DATABASE ID RELEASE 97%5654699 SHC-mediated cascade:FGFR2 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 97%168142 Toll Like Receptor 10 (TLR10) Cascade PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 97%1250342 PI3K events in ERBB4 signaling NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME DATABASE ID RELEASE 97%9865113 Loss-of-function mutations in DBT cause MSUD2 COBALAMIN (CBL) METABOLISM%REACTOME DATABASE ID RELEASE 97%9759218 Cobalamin (Cbl) metabolism DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 97%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME DATABASE ID RELEASE 97%3108214 SUMOylation of DNA damage response and repair proteins INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.14 Infectious disease SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME%R-HSA-9692916.2 SARS-CoV-1 activates modulates innate immune responses TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.4 Transport of the SLBP Dependant Mature mRNA FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 97%173599 Formation of the active cofactor, UDP-glucuronate ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 97%9918476 Assembly and Release of Dengue Virus Virions DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 97%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 97%379397 Enzymatic degradation of dopamine by COMT TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3645790 TGFBR2 Kinase Domain Mutants in Cancer AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9612973 Autophagy DEFENSINS%REACTOME%R-HSA-1461973.3 Defensins SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 97%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport TGFBR3 EXPRESSION%REACTOME%R-HSA-9839394.2 TGFBR3 expression NUCLEOTIDE METABOLISM%REACTOME DATABASE ID RELEASE 97%15869 Nucleotide metabolism DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME DATABASE ID RELEASE 97%9629232 Defective Base Excision Repair Associated with NEIL3 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 97%5607761 Dectin-1 mediated noncanonical NF-kB signaling EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.4 Extension of Telomeres DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 97%5690714 CD22 mediated BCR regulation LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME DATABASE ID RELEASE 97%9723907 Loss of Function of TP53 in Cancer PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%9931295 PD-L1(CD274) glycosylation and translocation to plasma membrane FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190373 FGFR1c ligand binding and activation DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 97%5609976 Defective GALK1 causes GALCT2 SODIUM CALCIUM EXCHANGERS%REACTOME%R-HSA-425561.4 Sodium Calcium exchangers TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.5 Telomere C-strand (Lagging Strand) Synthesis TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 97%110320 Translesion Synthesis by POLH ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%175474 Assembly Of The HIV Virion FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 97%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.5 Formation of ATP by chemiosmotic coupling TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME%R-HSA-168181.9 Toll Like Receptor 7 8 (TLR7 8) Cascade INTERLEUKIN-1 PROCESSING%REACTOME DATABASE ID RELEASE 97%448706 Interleukin-1 processing SYNDECAN INTERACTIONS%REACTOME%R-HSA-3000170.4 Syndecan interactions ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620912 Anchoring of the basal body to the plasma membrane SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME DATABASE ID RELEASE 97%168277 Influenza Virus Induced Apoptosis BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.4 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 97%2161517 Abacavir transmembrane transport SYNTHESIS OF PS%REACTOME%R-HSA-1483101.3 Synthesis of PS FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654727 Negative regulation of FGFR2 signaling CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-HSA-264870.3 Caspase-mediated cleavage of cytoskeletal proteins GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 97%3229121 Glycogen storage diseases ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-9660821.4 ADORA2B mediated anti-inflammatory cytokines production EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 97%3928663 EPHA-mediated growth cone collapse TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 97%4793953 Defective B4GALT1 causes CDG-2d FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex RUNX3 REGULATES NOTCH SIGNALING%REACTOME%R-HSA-8941856.2 RUNX3 regulates NOTCH signaling TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 97%917977 Transferrin endocytosis and recycling LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 97%9620244 Long-term potentiation MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 97%9694493 Maturation of protein E DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 97%4085023 Defective GFPT1 causes CMSTA1 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772572 Early SARS-CoV-2 Infection Events METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 97%196854 Metabolism of vitamins and cofactors NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%168638 NOD1 2 Signaling Pathway ACTIVATION OF PKB%REACTOME DATABASE ID RELEASE 97%165158 Activation of PKB METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.8 Metabolism of polyamines DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.4 Digestion and absorption G2 PHASE%REACTOME%R-HSA-68911.6 G2 Phase TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins CILIUM ASSEMBLY%REACTOME DATABASE ID RELEASE 97%5617833 Cilium Assembly RETINOID CYCLE DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%2453864 Retinoid cycle disease events CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 97%8955332 Carboxyterminal post-translational modifications of tubulin SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655302 Signaling by FGFR1 in disease GLUCOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-194002.4 Glucocorticoid biosynthesis DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME DATABASE ID RELEASE 97%5654219 Phospholipase C-mediated cascade: FGFR1 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203754 NOSIP mediated eNOS trafficking REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME DATABASE ID RELEASE 97%9926550 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME%R-HSA-5223345.7 Miscellaneous transport and binding events RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME%R-HSA-9828642.1 Respiratory syncytial virus genome transcription SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 97%75876 Synthesis of very long-chain fatty acyl-CoAs TBC RABGAPS%REACTOME DATABASE ID RELEASE 97%8854214 TBC RABGAPs BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%1307965 betaKlotho-mediated ligand binding NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 97%6783984 Glycine degradation COMPLEX IV ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9864848 Complex IV assembly DEFECTIVE CBLIF CAUSES IFD%REACTOME%R-HSA-3359457.4 Defective CBLIF causes IFD PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.3 PERK regulates gene expression RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 97%9665250 Resistance of ERBB2 KD mutants to AEE788 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 97%4570464 SUMOylation of RNA binding proteins TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs LYSINE CATABOLISM%REACTOME%R-HSA-71064.8 Lysine catabolism TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME%R-HSA-9014325.5 TICAM1,TRAF6-dependent induction of TAK1 complex APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 97%140342 Apoptosis induced DNA fragmentation REPRODUCTION%REACTOME DATABASE ID RELEASE 97%1474165 Reproduction CRMPS IN SEMA3A SIGNALING%REACTOME DATABASE ID RELEASE 97%399956 CRMPs in Sema3A signaling CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 97%177128 Conjugation of salicylate with glycine ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 97%5619060 Defective CP causes aceruloplasminemia (ACERULOP) SIGNALING BY GSK3BETA MUTANTS%REACTOME DATABASE ID RELEASE 97%5339716 Signaling by GSK3beta mutants 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 97%451326 Activation of kainate receptors upon glutamate binding DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2474795 Diseases associated with visual transduction MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) OPSINS%REACTOME DATABASE ID RELEASE 97%419771 Opsins REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-HSA-453276.4 Regulation of mitotic cell cycle MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.6 MyD88 dependent cascade initiated on endosome RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME%R-HSA-9665246.2 Resistance of ERBB2 KD mutants to neratinib ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-HSA-111452.4 Activation and oligomerization of BAK protein IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 97%937042 IRAK2 mediated activation of TAK1 complex REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696400 Dual Incision in GG-NER CELL CYCLE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69620 Cell Cycle Checkpoints DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%73864 RNA Polymerase I Transcription ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 97%390696 Adrenoceptors FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME%R-HSA-2644605.3 FBXW7 Mutants and NOTCH1 in Cancer CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME%R-HSA-9636383.4 Prevention of phagosomal-lysosomal fusion COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 97%6811434 COPI-dependent Golgi-to-ER retrograde traffic DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 97%1266738 Developmental Biology SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190375 FGFR2c ligand binding and activation ADIPOGENESIS%REACTOME DATABASE ID RELEASE 97%9843745 Adipogenesis GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME%R-HSA-8856688.2 Golgi-to-ER retrograde transport ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 97%418346 Platelet homeostasis DRUG RESISTANCE OF ALK MUTANTS%REACTOME%R-HSA-9700649.4 Drug resistance of ALK mutants ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion MITF-M-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9856651 MITF-M-dependent gene expression ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 97%9034793 Activated NTRK3 signals through PLCG1 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5609975 Diseases associated with glycosylation precursor biosynthesis BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME DATABASE ID RELEASE 97%4411364 Binding of TCF LEF:CTNNB1 to target gene promoters CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358751 CTNNB1 S45 mutants aren't phosphorylated DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence FLT3 SIGNALING IN DISEASE%REACTOME%R-HSA-9682385.3 FLT3 signaling in disease REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME DATABASE ID RELEASE 97%9824585 Regulation of MITF-M-dependent genes involved in pigmentation RHO GTPASES ACTIVATE CIT%REACTOME%R-HSA-5625900.4 RHO GTPases activate CIT MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME%R-HSA-77286.4 mitochondrial fatty acid beta-oxidation of saturated fatty acids PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME%R-HSA-202427.8 Phosphorylation of CD3 and TCR zeta chains SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME DATABASE ID RELEASE 97%3065679 SUMO is proteolytically processed P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 97%5467333 APC truncation mutants are not K63 polyubiquitinated NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.5 Notch-HLH transcription pathway GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 97%5610785 GLI3 is processed to GLI3R by the proteasome SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702577.2 semaxanib-resistant FLT3 mutants FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190322 FGFR4 ligand binding and activation INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 97%203615 eNOS activation EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296071 Potassium Channels ZINC TRANSPORTERS%REACTOME%R-HSA-435354.4 Zinc transporters TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 97%5602571 TRAF3 deficiency - HSE RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 97%73728 RNA Polymerase I Promoter Opening TGFBR1 LBD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656535 TGFBR1 LBD Mutants in Cancer IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 97%2428924 IGF1R signaling cascade SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer CALCINEURIN ACTIVATES NFAT%REACTOME%R-HSA-2025928.4 Calcineurin activates NFAT BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 97%9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 97%5654221 Phospholipase C-mediated cascade; FGFR2 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 97%428890 Role of ABL in ROBO-SLIT signaling DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME%R-HSA-3371598.3 Defective BTD causes biotidinase deficiency DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME%R-HSA-419408.5 Lysosphingolipid and LPA receptors CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9955542 CPS1 variants cause CPS1 deficiency IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation JOSEPHIN DOMAIN DUBS%REACTOME%R-HSA-5689877.3 Josephin domain DUBs SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME DATABASE ID RELEASE 97%426486 Small interfering RNA (siRNA) biogenesis DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654693 FRS-mediated FGFR1 signaling CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9948011 CASP5 inflammasome assembly DEFECTIVE B3GALTL CAUSES PPS%REACTOME DATABASE ID RELEASE 97%5083635 Defective B3GALTL causes PpS LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 97%9772573 Late SARS-CoV-2 Infection Events PROTEIN HYDROXYLATION%REACTOME DATABASE ID RELEASE 97%9629569 Protein hydroxylation INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 97%169131 Inhibition of PKR REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME DATABASE ID RELEASE 97%9843970 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%9006925 Intracellular signaling by second messengers INVADOPODIA FORMATION%REACTOME%R-HSA-8941237.3 Invadopodia formation TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME%R-HSA-9013957.3 TLR3-mediated TICAM1-dependent programmed cell death FORMATION OF LATERAL PLATE MESODERM%REACTOME%R-HSA-9758920.3 Formation of lateral plate mesoderm EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9940951 Interaction of NuRD complexes with transcription factors RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%6793080 rRNA modification in the mitochondrion PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.3 MyD88 cascade initiated on plasma membrane FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME DATABASE ID RELEASE 97%1222556 ROS and RNS production in phagocytes DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9686347 Microbial modulation of RIPK1-mediated regulated necrosis SIGNALING BY RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%6802949 Signaling by RAS mutants LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME DATABASE ID RELEASE 97%9944971 Loss of Function of KMT2D in Kabuki Syndrome TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME DATABASE ID RELEASE 97%69560 Transcriptional activation of p53 responsive genes GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 97%9652817 Signaling by MAPK mutants SIGNALING BY WNT%REACTOME DATABASE ID RELEASE 97%195721 Signaling by WNT SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855167 Synthesis of pyrophosphates in the cytosol INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 97%9014843 Interleukin-33 signaling DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 97%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME%R-HSA-418889.5 Ligand-independent caspase activation via DCC G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%1660661 Sphingolipid de novo biosynthesis REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 97%3248023 Regulation by TREX1 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME%R-HSA-9931529.2 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME%R-HSA-9820962.1 Assembly and release of respiratory syncytial virus (RSV) virions RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%186763 Downstream signal transduction RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 97%8951430 RUNX3 regulates WNT signaling VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME DATABASE ID RELEASE 97%168330 Viral RNP Complexes in the Host Cell Nucleus GLUCONEOGENESIS%REACTOME%R-HSA-70263.8 Gluconeogenesis DEFECTIVE CUBN CAUSES MGA1%REACTOME%R-HSA-3359463.4 Defective CUBN causes MGA1 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9683701.6 Translation of Structural Proteins RND2 GTPASE CYCLE%REACTOME%R-HSA-9696270.2 RND2 GTPase cycle SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855183 Synthesis of IP2, IP, and Ins in the cytosol REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.2 RHO GTPases Activate Rhotekin and Rhophilins REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764560 Regulation of CDH1 Gene Transcription NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME DATABASE ID RELEASE 97%168333 NEP NS2 Interacts with the Cellular Export Machinery HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390650 Histamine receptors CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 97%421270 Cell-cell junction organization OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 97%9673163 Oleoyl-phe metabolism INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME DATABASE ID RELEASE 97%3304349 Loss of Function of SMAD2 3 in Cancer ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 97%9956529 ASL variants cause argininosuccinate aciduria NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%6787639 GDP-fucose biosynthesis SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 97%5654719 SHC-mediated cascade:FGFR4 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112307 Transmission across Electrical Synapses ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 97%1592389 Activation of Matrix Metalloproteinases AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.4 Amine Oxidase reactions CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 97%264876 Insulin processing DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME DATABASE ID RELEASE 97%5619066 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-83936.4 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME DATABASE ID RELEASE 97%1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 97%9927020 Heme assimilation SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 97%8985586 SLIT2:ROBO1 increases RHOA activity DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 97%1614558 Degradation of cysteine and homocysteine REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.3 Regulation of HSF1-mediated heat shock response SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME DATABASE ID RELEASE 97%177162 Conjugation of phenylacetate with glutamine GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 97%70326 Glucose metabolism MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.5 Chromatin organization HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 97%392517 Rap1 signalling CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 97%156590 Glutathione conjugation ICOS CO-STIMULATION%REACTOME DATABASE ID RELEASE 97%9927354 ICOS co-stimulation DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 97%390648 Muscarinic acetylcholine receptors NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9675108 Nervous system development O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 97%1480926 O2 CO2 exchange in erythrocytes DISEASES OF THE NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%9675143 Diseases of the neuronal system INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.9 Interferon alpha beta signaling NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 97%187024 NGF-independant TRKA activation FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190374 FGFR1c and Klotho ligand binding and activation ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 97%68616 Assembly of the ORC complex at the origin of replication RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME DATABASE ID RELEASE 97%8939245 RUNX1 regulates transcription of genes involved in BCR signaling METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions FLT3 MUTANTS BIND TKIS%REACTOME%R-HSA-9702509.2 FLT3 mutants bind TKIs HH MUTANTS ARE DEGRADED BY ERAD%REACTOME DATABASE ID RELEASE 97%5362768 Hh mutants are degraded by ERAD LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69109 Leading Strand Synthesis MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 97%8949215 Mitochondrial calcium ion transport NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 97%383280 Nuclear Receptor transcription pathway PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 97%2160456 Phenylketonuria DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022923 DS-GAG biosynthesis RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%110381 Resolution of AP sites via the single-nucleotide replacement pathway EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 97%9648025 EML4 and NUDC in mitotic spindle formation CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 97%8963888 Chylomicron assembly SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 97%5654704 SHC-mediated cascade:FGFR3 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs TRANSCRIPTIONAL REGULATION OF MULTICILIOGENESIS%REACTOME DATABASE ID RELEASE 97%9945556 Transcriptional regulation of multiciliogenesis BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 97%194068 Bile acid and bile salt metabolism ADHERENS JUNCTIONS INTERACTIONS%REACTOME DATABASE ID RELEASE 97%418990 Adherens junctions interactions COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 97%9931269 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME DATABASE ID RELEASE 97%9006821 Alternative Lengthening of Telomeres (ALT) SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 97%9669933 Signaling by kinase domain mutants of KIT G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-9969901.1 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 97%391906 Leukotriene receptors SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 97%1855204 Synthesis of IP3 and IP4 in the cytosol NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 97%71384 Ethanol oxidation DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 97%376172 DSCAM interactions RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 97%5627083 RHO GTPases regulate CFTR trafficking VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME%R-HSA-432040.5 Vasopressin regulates renal water homeostasis via Aquaporins ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins DEPURINATION%REACTOME DATABASE ID RELEASE 97%73927 Depurination TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 97%918233 TRAF3-dependent IRF activation pathway RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 97%6802953 RAS signaling downstream of NF1 loss-of-function variants SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 97%9034015 Signaling by NTRK3 (TRKC) SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 97%5637810 Constitutive Signaling by EGFRvIII RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 97%6811440 Retrograde transport at the Trans-Golgi-Network DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%2173788 Downregulation of TGF-beta receptor signaling GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 97%446205 Synthesis of GDP-mannose DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME%R-HSA-9754119.3 Drug-mediated inhibition of CDK4 CDK6 activity METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.12 Metabolism of Angiotensinogen to Angiotensins RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development ATTACHMENT AND ENTRY%REACTOME%R-HSA-9678110.5 Attachment and Entry REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 97%210747 Regulation of gene expression in early pancreatic precursor cells TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 97%112315 Transmission across Chemical Synapses RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation SENSORY PERCEPTION OF SOUR TASTE%REACTOME%R-HSA-9729555.2 Sensory perception of sour taste RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME%R-HSA-6791461.4 RPIA deficiency: failed conversion of RU5P to R5P REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.7 Regulation of Glucokinase by Glucokinase Regulatory Protein RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME DATABASE ID RELEASE 97%5659996 RPIA deficiency: failed conversion of R5P to RU5P TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.5 RNA Polymerase II Promoter Escape BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 97%437239 Recycling pathway of L1 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 97%6807878 COPI-mediated anterograde transport DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 97%9769726 Defects of Coagulation cascade KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 97%211945 Phase I - Functionalization of compounds SIGNALING BY RAF1 MUTANTS%REACTOME DATABASE ID RELEASE 97%9656223 Signaling by RAF1 mutants G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME DATABASE ID RELEASE 97%392451 G beta:gamma signalling through PI3Kgamma HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 97%167169 HIV Transcription Elongation CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.4 Creation of C4 and C2 activators DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 97%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.6 Mitochondrial translation LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 97%9005891 Loss of function of MECP2 in Rett syndrome DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere SIGNALING BY CSF3 (G-CSF)%REACTOME%R-HSA-9674555.4 Signaling by CSF3 (G-CSF) FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 97%1566977 Fibronectin matrix formation ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 97%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate METABOLISM OF STEROIDS%REACTOME DATABASE ID RELEASE 97%8957322 Metabolism of steroids APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 97%8964539 Glutamate and glutamine metabolism METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 97%196757 Metabolism of folate and pterines DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 97%3656225 Defective CHST6 causes MCDC1 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME%R-HSA-9637628.2 Modulation by Mtb of host immune system TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.2 RHO GTPases Activate Formins RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 97%380270 Recruitment of mitotic centrosome proteins and complexes TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8931838 DAG1 glycosylations RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013423 RAC3 GTPase cycle WNT MEDIATED ACTIVATION OF DVL%REACTOME DATABASE ID RELEASE 97%201688 WNT mediated activation of DVL DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%9734009 Defective Intrinsic Pathway for Apoptosis TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 97%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME DATABASE ID RELEASE 97%5626978 TNFR1-mediated ceramide production ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 97%9645460 ALPK1 signaling pathway CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.4 Cell junction organization INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 97%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 97%916853 Degradation of GABA INTERLEUKIN-10 SIGNALING%REACTOME%R-HSA-6783783.5 Interleukin-10 signaling DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 97%9824443 Parasitic Infection Pathways MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME DATABASE ID RELEASE 97%9841251 Mitochondrial unfolded protein response (UPRmt) TRANSLESION SYNTHESIS BY POLK%REACTOME DATABASE ID RELEASE 97%5655862 Translesion synthesis by POLK CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%191273 Cholesterol biosynthesis CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.3 Class I peroxisomal membrane protein import NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%447043 Neurofascin interactions CELL DIVISION%REACTOME%R-HSA-68884.6 cell division METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 97%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se SIGNALING BY NTRK1 (TRKA)%REACTOME DATABASE ID RELEASE 97%187037 Signaling by NTRK1 (TRKA) PD-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%389948 PD-1 signaling DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 97%5679096 Defective ABCG5 causes sitosterolemia TRANSPORT OF RCBL WITHIN THE BODY%REACTOME DATABASE ID RELEASE 97%9758890 Transport of RCbl within the body 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 97%4793952 Defective MGAT2 causes CDG-2a REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 97%9769739 Regulation of clotting cascade SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 97%8849932 Synaptic adhesion-like molecules ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME%R-HSA-1169410.11 Antiviral mechanism by IFN-stimulated genes OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 97%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha DEFECTIVE MMACHC CAUSES MAHCC%REACTOME%R-HSA-3359474.4 Defective MMACHC causes MAHCC RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation XAV939 STABILIZES AXIN%REACTOME%R-HSA-5545619.4 XAV939 stabilizes AXIN PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%438064 Post NMDA receptor activation events G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69473 G2 M DNA damage checkpoint DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME DATABASE ID RELEASE 97%5083627 Defective LARGE causes MDDGA6 and MDDGB6 METHIONINE SALVAGE PATHWAY%REACTOME%R-HSA-1237112.4 Methionine salvage pathway THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME DATABASE ID RELEASE 97%164952 The role of Nef in HIV-1 replication and disease pathogenesis RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 97%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 97%2187335 The retinoid cycle in cones (daylight vision) FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 97%9761174 Formation of intermediate mesoderm MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205647 Mitophagy GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.4 Lactose synthesis REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975578 Reactions specific to the complex N-glycan synthesis pathway GLUCURONIDATION%REACTOME DATABASE ID RELEASE 97%156588 Glucuronidation PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 97%114608 Platelet degranulation DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 97%3134963 DEx H-box helicases activate type I IFN and inflammatory cytokines production INTEGRATION OF PROVIRUS%REACTOME DATABASE ID RELEASE 97%162592 Integration of provirus NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 97%9034013 NTF3 activates NTRK3 signaling SIGNALING BY LTK%REACTOME DATABASE ID RELEASE 97%9842663 Signaling by LTK DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9613829 Chaperone Mediated Autophagy CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358752 CTNNB1 T41 mutants aren't phosphorylated CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 97%1296052 Ca activated K+ channels NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME%R-HSA-9818032.1 NFE2L2 regulating MDR associated enzymes ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 97%9603381 Activated NTRK3 signals through PI3K DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 97%6785807 Interleukin-4 and Interleukin-13 signaling DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 97%5633231 Defective ALG14 causes ALG14-CMS SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME DATABASE ID RELEASE 97%9959399 SLC-mediated transport of oligopeptides CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME DATABASE ID RELEASE 97%446353 Cell-extracellular matrix interactions ION TRANSPORT BY P-TYPE ATPASES%REACTOME DATABASE ID RELEASE 97%936837 Ion transport by P-type ATPases REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 97%9617629 Regulation of FOXO transcriptional activity by acetylation REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9614399 Regulation of localization of FOXO transcription factors REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME DATABASE ID RELEASE 97%3134975 Regulation of innate immune responses to cytosolic DNA THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 97%428930 Thromboxane signalling through TP receptor PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.4 Neuropilin interactions with VEGF and VEGFR DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME DATABASE ID RELEASE 97%9656249 Defective Base Excision Repair Associated with OGG1 MITOCHONDRIAL MRNA MODIFICATION%REACTOME%R-HSA-9937008.1 Mitochondrial mRNA modification ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 97%9914355 Isovaleric acidemia SUCCINYL-COA BIOSYNTHESIS%REACTOME%R-HSA-9853506.1 Succinyl-CoA Biosynthesis HDMS DEMETHYLATE HISTONES%REACTOME DATABASE ID RELEASE 97%3214842 HDMs demethylate histones TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 97%168138 Toll Like Receptor 9 (TLR9) Cascade GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%420092 Glucagon-type ligand receptors INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 97%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109581 Apoptosis MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%947581 Molybdenum cofactor biosynthesis FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 97%9831926 Nephron development ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 97%139915 Activation of PUMA and translocation to mitochondria DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME DATABASE ID RELEASE 97%9820448 Developmental Cell Lineages of the Exocrine Pancreas CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.6 Acetylcholine Neurotransmitter Release Cycle SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 97%9675136 Diseases of DNA Double-Strand Break Repair FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5658623 FGFRL1 modulation of FGFR1 signaling SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 97%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1250196.6 SHC1 events in ERBB2 signaling HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.3 HATs acetylate histones HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 97%5387390 Hh mutants abrogate ligand secretion TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME DATABASE ID RELEASE 97%6803211 TP53 Regulates Transcription of Death Receptors and Ligands INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 97%109606 Intrinsic Pathway for Apoptosis JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 97%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME%R-HSA-112313.5 Neurotransmitter uptake and metabolism In glial cells RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 97%5638303 Inhibition of Signaling by Overexpressed EGFR RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802946 Signaling by moderate kinase activity BRAF mutants DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME%R-HSA-9672387.3 Defective F8 accelerates dissociation of the A2 domain DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%R-HSA-3296469.6 Defects in cobalamin (B12) metabolism MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 97%5657655 MGMT-mediated DNA damage reversal ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME%R-HSA-9027277.3 Erythropoietin activates Phospholipase C gamma (PLCG) SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 97%201451 Signaling by BMP AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME DATABASE ID RELEASE 97%141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9865118 Diseases of branched-chain amino acid catabolism RECEPTOR MEDIATED MITOPHAGY%REACTOME%R-HSA-8934903.5 Receptor Mediated Mitophagy SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME DATABASE ID RELEASE 97%9649948 Signaling downstream of RAS mutants BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%73884 Base Excision Repair NEF AND SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 97%164944 Nef and signal transduction IRE1ALPHA ACTIVATES CHAPERONES%REACTOME%R-HSA-381070.3 IRE1alpha activates chaperones MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 97%382551 Transport of small molecules U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 97%72165 U12 Dependent Splicing PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 97%1912408 Pre-NOTCH Transcription and Translation NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9764725 Negative Regulation of CDH1 Gene Transcription RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 97%2142688 Synthesis of 5-eicosatetraenoic acids G1 PHASE%REACTOME%R-HSA-69236.6 G1 Phase BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373080 Class B 2 (Secretin family receptors) ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 97%446203 Asparagine N-linked glycosylation DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 97%3769402 Deactivation of the beta-catenin transactivating complex IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 97%212718 EGFR interacts with phospholipase C-gamma GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 97%9953170 GBP-mediated host defense OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956522 OTC variants cause OTC deficiency SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839120 Signaling by FGFR1 amplification mutants EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME%R-HSA-9619665.3 EGR2 and SOX10-mediated initiation of Schwann cell myelination INHIBITION OF MEMBRANE REPAIR%REACTOME%R-HSA-9635644.5 Inhibition of membrane repair INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%177243 Interactions of Rev with host cellular proteins POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels DISEASES OF TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 97%9673013 Diseases of Telomere Maintenance TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.8 Olfactory Signaling Pathway OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 97%3595172 Defective CHST3 causes SEDCJD NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5676590.3 NIK-->noncanonical NF-kB signaling HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.4 Homology Directed Repair GALACTOSE CATABOLISM%REACTOME%R-HSA-70370.7 Galactose catabolism PHENYLALANINE METABOLISM%REACTOME%R-HSA-8964208.2 Phenylalanine metabolism SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 97%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 97%8942233 Intestinal infectious diseases DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 97%73928 Depyrimidination RIBAVIRIN ADME%REACTOME DATABASE ID RELEASE 97%9755088 Ribavirin ADME GLYCOSPHINGOLIPID TRANSPORT%REACTOME DATABASE ID RELEASE 97%9845576 Glycosphingolipid transport TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 97%168927 TICAM1, RIP1-mediated IKK complex recruitment UNCOATING OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 97%162585 Uncoating of the HIV Virion ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 97%9028731 Activated NTRK2 signals through FRS2 and FRS3 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME%R-HSA-6814848.2 Glycerophospholipid catabolism NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME DATABASE ID RELEASE 97%9636003 NEIL3-mediated resolution of ICLs DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions GLYCOSPHINGOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 97%9840310 Glycosphingolipid catabolism NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 97%9013694 Signaling by NOTCH4 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110329 Cleavage of the damaged pyrimidine L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME%R-HSA-9960525.1 CASP5-mediated substrate cleavage TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 97%9845622 Defective VWF binding to collagen type I ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME%R-HSA-2046106.2 alpha-linolenic acid (ALA) metabolism NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME%R-HSA-9705462.2 Inactivation of CSF3 (G-CSF) signaling SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%9022707 MECP2 regulates transcription factors GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-1630316.7 Glycosaminoglycan metabolism NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 97%9706369 Negative regulation of FLT3 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-110362.4 POLB-Dependent Long Patch Base Excision Repair REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8934593 Regulation of RUNX1 Expression and Activity VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 97%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 97%5651801 PCNA-Dependent Long Patch Base Excision Repair DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9969896 Lanosterol biosynthesis KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 97%9700645 ALK mutants bind TKIs HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.4 HuR (ELAVL1) binds and stabilizes mRNA SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 97%174577 Activation of C3 and C5 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME%R-HSA-8876384.4 Listeria monocytogenes entry into host cells DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 97%9759774 Diseases of mitochondrial beta oxidation REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 97%9861718 Regulation of pyruvate metabolism CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 97%5620920 Cargo trafficking to the periciliary membrane RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 97%8935964 RUNX1 regulates expression of components of tight junctions CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964026 Chylomicron clearance PEROXISOMAL PROTEIN IMPORT%REACTOME%R-HSA-9033241.5 Peroxisomal protein import TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.4 Toxicity of botulinum toxin type G (botG) NEF MEDIATED CD4 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%167590 Nef Mediated CD4 Down-regulation MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 97%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 97%2299718 Condensation of Prophase Chromosomes HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 97%5358346 Hedgehog ligand biogenesis CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 97%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 97%69186 Lagging Strand Synthesis SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9938024.1 Somatic hypermutation of immunoglobulin genes GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 97%3322077 Glycogen synthesis INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176033 Interactions of Vpr with host cellular proteins TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 97%9616222 Transcriptional regulation of granulopoiesis NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 97%203641 NOSTRIN mediated eNOS trafficking KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation EARLY PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 97%162594 Early Phase of HIV Life Cycle CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 97%901042 Calnexin calreticulin cycle REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME%R-HSA-9968551.1 Regulation of GBP-mediated host defense CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717326.3 crizotinib-resistant ALK mutants ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 97%419812 Calcitonin-like ligand receptors REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.4 Regulation of thyroid hormone activity INTEGRIN CELL SURFACE INTERACTIONS%REACTOME%R-HSA-216083.6 Integrin cell surface interactions CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME%R-HSA-173623.4 Classical antibody-mediated complement activation PROCESSING AND ACTIVATION OF SUMO%REACTOME DATABASE ID RELEASE 97%3215018 Processing and activation of SUMO METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 97%72200 mRNA Editing: C to U Conversion CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.4 PAOs oxidise polyamines to amines CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 97%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants RHOC GTPASE CYCLE%REACTOME%R-HSA-9013106.2 RHOC GTPase cycle REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 97%381426 Regulation of IGF Activity by IGFBP DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 97%4419969 Depolymerization of the Nuclear Lamina XENOBIOTICS%REACTOME%R-HSA-211981.3 Xenobiotics H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME DATABASE ID RELEASE 97%9912529 H139Hfs13* PPM1K causes a mild variant of MSUD NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.3 NRIF signals cell death from the nucleus BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.3 Beta oxidation of octanoyl-CoA to hexanoyl-CoA DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME DATABASE ID RELEASE 97%5682294 Defective ABCA12 causes ARCI4B REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 97%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 97%111458 Formation of apoptosome PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.2 PDGFR mutants bind TKIs PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 97%163358 PKA-mediated phosphorylation of key metabolic factors DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.4 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SUPPRESSION OF APOPTOSIS%REACTOME%R-HSA-9635465.2 Suppression of apoptosis MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME%R-HSA-5685939.3 HDR through MMEJ (alt-NHEJ) TGFBR1 KD MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3656532 TGFBR1 KD Mutants in Cancer DISEASES OF DNA REPAIR%REACTOME%R-HSA-9675135.6 Diseases of DNA repair REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME%R-HSA-9759476.1 Regulation of Homotypic Cell-Cell Adhesion VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME%R-HSA-5218921.5 VEGFR2 mediated cell proliferation SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 97%445144 Signal transduction by L1 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME%R-HSA-1222499.4 Latent infection - Other responses of Mtb to phagocytosis PLASMA LIPOPROTEIN CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964043 Plasma lipoprotein clearance ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 97%426048 Arachidonate production from DAG METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 97%8853383 Lysosomal oligosaccharide catabolism CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 97%211999 CYP2E1 reactions MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 97%9953080 MPS VII - Sly syndrome (CS DS degradation) SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME DATABASE ID RELEASE 97%446219 Synthesis of substrates in N-glycan biosythesis FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 97%5654712 FRS-mediated FGFR4 signaling P75NTR SIGNALS VIA NF-KB%REACTOME DATABASE ID RELEASE 97%193639 p75NTR signals via NF-kB SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME DATABASE ID RELEASE 97%349425 Autodegradation of the E3 ubiquitin ligase COP1 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 97%162588 Budding and maturation of HIV virion UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D IMPAIRED BRCA2 BINDING TO PALB2%REACTOME DATABASE ID RELEASE 97%9709603 Impaired BRCA2 binding to PALB2 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 97%167238 Pausing and recovery of Tat-mediated HIV elongation ERROR-PRONE MISMATCH REPAIR HYPERMUTATES IMMUNOGLOBULIN GENES%REACTOME%R-HSA-9968295.1 Error-prone mismatch repair hypermutates immunoglobulin genes OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.8 Oxidative Stress Induced Senescence INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 97%176034 Interactions of Tat with host cellular proteins NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%9013508 NOTCH3 Intracellular Domain Regulates Transcription ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111448.5 Activation of NOXA and translocation to mitochondria DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.3 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation VEGFA-VEGFR2 PATHWAY%REACTOME%R-HSA-4420097.6 VEGFA-VEGFR2 Pathway DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 97%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 COLLAGEN DEGRADATION%REACTOME%R-HSA-1442490.5 Collagen degradation REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME%R-HSA-204174.5 Regulation of pyruvate dehydrogenase (PDH) complex CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME%R-HSA-5336415.3 Uptake and function of diphtheria toxin PI3K CASCADE%REACTOME DATABASE ID RELEASE 97%109704 PI3K Cascade RETINOID METABOLISM DISEASE EVENTS%REACTOME DATABASE ID RELEASE 97%6809583 Retinoid metabolism disease events FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME%R-HSA-72689.3 Formation of a pool of free 40S subunits TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 97%9839406 TGFBR3 regulates activin signaling TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 97%168176 Toll Like Receptor 5 (TLR5) Cascade CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358747 CTNNB1 S33 mutants aren't phosphorylated PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.5 Pyrophosphate hydrolysis RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 97%749476 RNA Polymerase III Abortive And Retractive Initiation SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME DATABASE ID RELEASE 97%1839117 Signaling by cytosolic FGFR1 fusion mutants INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways DEFECTIVE MUT CAUSES MMAM%REACTOME DATABASE ID RELEASE 97%3359478 Defective MUT causes MMAM POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.5 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%69306 DNA Replication INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling CLEC7A INFLAMMASOME PATHWAY%REACTOME%R-HSA-5660668.2 CLEC7A inflammasome pathway PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%209952 Peptide hormone biosynthesis BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 97%3656248 Defective HEXB causes GM2-gangliosidosis 2 PROTEIN LOCALIZATION%REACTOME%R-HSA-9609507.4 Protein localization SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death REELIN SIGNALLING PATHWAY%REACTOME%R-HSA-8866376.4 Reelin signalling pathway SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer THE AIM2 INFLAMMASOME%REACTOME DATABASE ID RELEASE 97%844615 The AIM2 inflammasome ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.4 Activation of Ca-permeable Kainate Receptor EFFECTS OF PIP2 HYDROLYSIS%REACTOME DATABASE ID RELEASE 97%114508 Effects of PIP2 hydrolysis LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037629.2 Lewis blood group biosynthesis GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.3 GRB2:SOS provides linkage to MAPK signaling for Integrins LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.4 Maturation of spike protein RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.4 RNA polymerase II transcribes snRNA genes SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 97%5683826 Surfactant metabolism PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 97%6794362 Protein-protein interactions at synapses REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 97%9764561 Regulation of CDH1 Function RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME DATABASE ID RELEASE 97%9820952 Respiratory Syncytial Virus Infection Pathway DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 97%3595174 Defective CHST14 causes EDS, musculocontractural type REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 97%9627069 Regulation of the apoptosome activity TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 97%167243 Tat-mediated HIV elongation arrest and recovery TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 97%379724 tRNA Aminoacylation DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.9 Interferon gamma signaling ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME%R-HSA-8874177.3 ATF6B (ATF6-beta) activates chaperones TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 97%948021 Transport to the Golgi and subsequent modification CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717323 ceritinib-resistant ALK mutants LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 97%9615710 Late endosomal microautophagy THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases CHOLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%6798163 Choline catabolism DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 97%5654696 Downstream signaling of activated FGFR2 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.2 Regorafenib-resistant PDGFR mutants DAG1 CORE M2 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932504 DAG1 core M2 glycosylations TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.5 activated TAK1 mediates p38 MAPK activation SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 97%9012852 Signaling by NOTCH3 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency DARPP-32 EVENTS%REACTOME DATABASE ID RELEASE 97%180024 DARPP-32 events MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 97%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes MTOR SIGNALLING%REACTOME%R-HSA-165159.10 MTOR signalling CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.5 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.4 Defective CYP21A2 causes AH3 FERTILIZATION%REACTOME DATABASE ID RELEASE 97%1187000 Fertilization DEFECTIVE GALT CAN CAUSE GALCT%REACTOME DATABASE ID RELEASE 97%5609978 Defective GALT can cause GALCT SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 97%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex THE NLRP1 INFLAMMASOME%REACTOME%R-HSA-844455.2 The NLRP1 inflammasome DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 97%5579015 Defective CYP26B1 causes RHFCA DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME DATABASE ID RELEASE 97%9924644 Developmental Lineages of the Mammary Gland MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 97%429958 mRNA decay by 3' to 5' exoribonuclease ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 97%169893 Prolonged ERK activation events SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 97%1614635 Sulfur amino acid metabolism RHOT2 GTPASE CYCLE%REACTOME%R-HSA-9013419.2 RHOT2 GTPase cycle ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME%R-HSA-2426168.6 Activation of gene expression by SREBF (SREBP) CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 97%5358749 CTNNB1 S37 mutants aren't phosphorylated SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.4 SARS-CoV-1 Genome Replication and Transcription MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination VLDL CLEARANCE%REACTOME DATABASE ID RELEASE 97%8964046 VLDL clearance MITOTIC PROPHASE%REACTOME%R-HSA-68875.7 Mitotic Prophase TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.6 CDC6 association with the ORC:origin complex CREB PHOSPHORYLATION%REACTOME%R-HSA-199920.3 CREB phosphorylation CYTOPROTECTION BY HMOX1%REACTOME DATABASE ID RELEASE 97%9707564 Cytoprotection by HMOX1 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013425 RHOT1 GTPase cycle RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 97%8941284 RUNX2 regulates chondrocyte maturation REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME%R-HSA-9759475.2 Regulation of CDH11 Expression and Function REGULATION OF TP53 ACTIVITY%REACTOME DATABASE ID RELEASE 97%5633007 Regulation of TP53 Activity GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 97%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 97%9693928 Defective RIPK1-mediated regulated necrosis DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME DATABASE ID RELEASE 97%9925563 Developmental Lineage of Pancreatic Ductal Cells TRNA PROCESSING%REACTOME DATABASE ID RELEASE 97%72306 tRNA processing HDL ASSEMBLY%REACTOME%R-HSA-8963896.2 HDL assembly OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956553 OTC main chain variants cause OTC deficiency IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 97%71262 Carnitine synthesis NUCLEOTIDE CATABOLISM DEFECTS%REACTOME DATABASE ID RELEASE 97%9735786 Nucleotide catabolism defects IFIT ANTIVIRAL RESPONSE%REACTOME%R-HSA-9684482.1 IFIT antiviral response T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.2 t(4;14) translocations of FGFR3 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes THREONINE CATABOLISM%REACTOME%R-HSA-8849175.6 Threonine catabolism DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 97%3560782 Diseases associated with glycosaminoglycan metabolism CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 97%9793528 Ciprofloxacin ADME DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%5619115 Disorders of transmembrane transporters RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME DATABASE ID RELEASE 97%76005 Response to elevated platelet cytosolic Ca2+ DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME%R-HSA-9656255.2 Defective OGG1 Substrate Binding DEATH RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%73887 Death Receptor Signaling E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME DATABASE ID RELEASE 97%113510 E2F mediated regulation of DNA replication PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%1989781 PPARA activates gene expression FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 97%444209 Free fatty acid receptors DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.2 RND1 GTPase cycle GAB1 SIGNALOSOME%REACTOME DATABASE ID RELEASE 97%180292 GAB1 signalosome DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 97%9918487 Dengue Virus Genome Translation and Replication SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-HSA-8866652.4 Synthesis of active ubiquitin: roles of E1 and E2 enzymes INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 97%1266695 Interleukin-7 signaling LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702596.2 lestaurtinib-resistant FLT3 mutants DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME DATABASE ID RELEASE 97%9725554 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%5662702 Melanin biosynthesis NEF MEDIATED CD8 DOWN-REGULATION%REACTOME%R-HSA-182218.5 Nef Mediated CD8 Down-regulation G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69478 G2 M DNA replication checkpoint TCR SIGNALING%REACTOME DATABASE ID RELEASE 97%202403 TCR signaling EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME DATABASE ID RELEASE 97%9646303 Evasion of Oncogene Induced Senescence Due to p14ARF Defects VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%168325 Viral Messenger RNA Synthesis FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-5661270.3 Formation of xylulose-5-phosphate CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 97%69231 Cyclin D associated events in G1 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 97%9006927 Signaling by Non-Receptor Tyrosine Kinases TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 97%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME%R-HSA-112303.3 Electric Transmission Across Gap Junctions SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.2 Signaling by juxtamembrane domain KIT mutants GLYCOLYSIS%REACTOME DATABASE ID RELEASE 97%70171 Glycolysis FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 97%2022090 Assembly of collagen fibrils and other multimeric structures TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME%R-HSA-9013973.6 TICAM1-dependent activation of IRF3 IRF7 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 97%5579004 Defective CYP26C1 causes FFDD4 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.5 Elevation of cytosolic Ca2+ levels P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 97%417957 P2Y receptors SENSORY PERCEPTION OF TASTE%REACTOME%R-HSA-9717189.3 Sensory perception of taste SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660825.3 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 97%3359471 Defective MMAB causes MMA, cblB type DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 97%4341670 Defective NEU1 causes sialidosis MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 97%8874081 MET activates PTK2 signaling REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 97%174437 Removal of the Flap Intermediate from the C-strand EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%3928664 Ephrin signaling INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9956551 OTC leader sequence variants cause OTC deficiency SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation ISG15 ANTIVIRAL MECHANISM%REACTOME%R-HSA-1169408.4 ISG15 antiviral mechanism RESPONSE TO METAL IONS%REACTOME%R-HSA-5660526.6 Response to metal ions PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.3 PTEN Loss of Function in Cancer THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME DATABASE ID RELEASE 97%456926 Thrombin signalling through proteinase activated receptors (PARs) INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.4 Interconversion of polyamines ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 97%879415 Advanced glycosylation endproduct receptor signaling DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 97%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) INTERLEUKIN-2 FAMILY SIGNALING%REACTOME%R-HSA-451927.7 Interleukin-2 family signaling DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME DATABASE ID RELEASE 97%5619070 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.6 Amino acid transport across the plasma membrane PACKAGING OF TELOMERE ENDS%REACTOME DATABASE ID RELEASE 97%171306 Packaging Of Telomere Ends RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 97%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 97%975574 Reactions specific to the hybrid N-glycan synthesis pathway DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 97%5609974 Defective PGM1 causes CDG1t DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME%R-HSA-561048.6 Organic anion transport by SLC22 transporters CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 97%1810476 RIP-mediated NFkB activation via ZBP1 ACYL CHAIN REMODELLING OF PC%REACTOME%R-HSA-1482788.5 Acyl chain remodelling of PC DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME DATABASE ID RELEASE 97%4551295 Defective ALG11 causes CDG-1p NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME DATABASE ID RELEASE 97%2995410 Nuclear Envelope (NE) Reassembly MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 97%2033519 Activated point mutants of FGFR2 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease GSD XV%REACTOME DATABASE ID RELEASE 97%3814836 GSD XV NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME%R-HSA-5619111.4 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 97%166662 Lectin pathway of complement activation SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME DATABASE ID RELEASE 97%9958810 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 97%9663199 Defective DNA double strand break response due to BRCA1 loss of function TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 97%3642279 TGFBR2 MSI Frameshift Mutants in Cancer DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME DATABASE ID RELEASE 97%9853846 Defective ANO6 does not expose PS, PE on the platelet membrane LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME DATABASE ID RELEASE 97%9022534 Loss of MECP2 binding ability to 5hmC-DNA POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 97%597592 Post-translational protein modification REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME DATABASE ID RELEASE 97%6804758 Regulation of TP53 Activity through Acetylation CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME%R-HSA-5357769.5 Caspase activation via extrinsic apoptotic signalling pathway ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS PROTEIN REPAIR%REACTOME%R-HSA-5676934.4 Protein repair DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9915355 Beta-ketothiolase deficiency RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.7 Scavenging by Class B Receptors SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.2 Scavenging by Class H Receptors ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5603041 IRAK4 deficiency (TLR2 4) MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME%R-HSA-8939242.2 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 97%9711097 Cellular response to starvation INTERLEUKIN-17 SIGNALING%REACTOME%R-HSA-448424.8 Interleukin-17 signaling DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 97%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.3 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%445355 Smooth Muscle Contraction ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.6 ESR-mediated signaling MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 97%5654708 Downstream signaling of activated FGFR3 GSD II%REACTOME%R-HSA-5357609.5 GSD II TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 97%71240 Tryptophan catabolism EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 97%168274 Export of Viral Ribonucleoproteins from Nucleus SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 97%6802948 Signaling by high-kinase activity BRAF mutants INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.3 Aryl hydrocarbon receptor signalling RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.7 Stimuli-sensing channels OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%416700 Other semaphorin interactions OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA CATECHOLAMINE BIOSYNTHESIS%REACTOME%R-HSA-209905.3 Catecholamine biosynthesis REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 97%73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.8 Neurotransmitter release cycle RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%73762 RNA Polymerase I Transcription Initiation RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 97%8868766 rRNA processing in the mitochondrion ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.2 Erythrocytes take up oxygen and release carbon dioxide NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME%R-HSA-9702506.3 Drug resistance of FLT3 mutants DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME%R-HSA-9673768.2 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%888568 GABA synthesis GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 97%1660662 Glycosphingolipid metabolism PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 97%5357801 Programmed Cell Death BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME%R-HSA-111464.5 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME DATABASE ID RELEASE 97%180585 Vif-mediated degradation of APOBEC3G VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 97%388479 Vasopressin-like receptors DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 97%68962 Activation of the pre-replicative complex DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.4 Expression of NOTCH2NL genes PLASMA LIPOPROTEIN ASSEMBLY%REACTOME%R-HSA-8963898.3 Plasma lipoprotein assembly PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-HSA-75067.4 Processing of Capped Intronless Pre-mRNA ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 97%1482798 Acyl chain remodeling of CL HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 97%5654736 Signaling by FGFR1 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME%R-HSA-9725370.3 Signaling by ALK fusions and activated point mutants ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296041 Activation of G protein gated Potassium channels ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 97%5688399 Defective ABCA3 causes SMDP3 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME DATABASE ID RELEASE 97%9825892 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport PRC2 METHYLATES HISTONES AND DNA%REACTOME DATABASE ID RELEASE 97%212300 PRC2 methylates histones and DNA NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME DATABASE ID RELEASE 97%375165 NCAM signaling for neurite out-growth ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 97%168316 Assembly of Viral Components at the Budding Site ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296025 ATP sensitive Potassium channels RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 97%444821 Relaxin receptors FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME DATABASE ID RELEASE 97%112382 Formation of RNA Pol II elongation complex FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%75105 Fatty acyl-CoA biosynthesis VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism ACTIVATION OF AMPA RECEPTORS%REACTOME%R-HSA-399710.4 Activation of AMPA receptors PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.4 Processing of DNA double-strand break ends EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%391903 Eicosanoid ligand-binding receptors PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 97%5205685 PINK1-PRKN Mediated Mitophagy VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 97%195399 VEGF binds to VEGFR leading to receptor dimerization DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 97%9927418 Developmental Lineage of Mammary Gland Luminal Epithelial Cells NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME%R-HSA-9955693.1 NAGS variants cause NAGS deficiency WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME%R-HSA-5140745.2 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 97%5624958 ARL13B-mediated ciliary trafficking of INPP5E DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 97%9734735 Defective ADA disrupts (deoxy)adenosine deamination DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME%R-HSA-9608290.3 Defective MUTYH substrate processing DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 97%381119 Unfolded Protein Response (UPR) DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME DATABASE ID RELEASE 97%4755579 Defective SRD5A3 causes CDG-1q and KHRZ HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME DATABASE ID RELEASE 97%4085011 Defective GNE causes sialuria, NK and IBM2 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 97%168276 NS1 Mediated Effects on Host Pathways RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9706574 RHOBTB GTPase Cycle TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.4 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674404.2 Sorafenib-resistant PDGFR mutants TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 97%4793950 Defective MAN1B1 causes MRT15 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME DATABASE ID RELEASE 97%9672396 Defective cofactor function of FVIIIa variant E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%113507 E2F-enabled inhibition of pre-replication complex formation HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.5 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors SIGNALING BY SCF-KIT%REACTOME DATABASE ID RELEASE 97%1433557 Signaling by SCF-KIT FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 97%442982 Ras activation upon Ca2+ influx through NMDA receptor REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 97%3560783 Defective B4GALT7 causes EDS, progeroid type INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 97%8983432 Interleukin-15 signaling SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.8 SUMO E3 ligases SUMOylate target proteins P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 97%209543 p75NTR recruits signalling complexes RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.5 rRNA processing in the nucleus and cytosol DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 97%4719377 Defective DPM2 causes CDG-1u PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling REGULATION OF NPAS4 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 97%9768759 Regulation of NPAS4 gene expression CITRIC ACID CYCLE (TCA CYCLE)%REACTOME DATABASE ID RELEASE 97%71403 Citric acid cycle (TCA cycle) GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9840309 Glycosphingolipid biosynthesis FLT3 SIGNALING BY CBL MUTANTS%REACTOME%R-HSA-9706377.2 FLT3 signaling by CBL mutants DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 97%6798695 Neutrophil degranulation FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 97%5683371 Defective ABCB6 causes MCOPCB7 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 97%5654227 Phospholipase C-mediated cascade; FGFR3 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702998.2 linifanib-resistant FLT3 mutants IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME DATABASE ID RELEASE 97%1606341 IRF3 mediated activation of type 1 IFN NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME DATABASE ID RELEASE 97%5619071 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 97%9662361 Sensory processing of sound by outer hair cells of the cochlea B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%5250924 B-WICH complex positively regulates rRNA expression DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME DATABASE ID RELEASE 97%9704331 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function MACROAUTOPHAGY%REACTOME%R-HSA-1632852.12 Macroautophagy REUPTAKE OF GABA%REACTOME%R-HSA-888593.5 Reuptake of GABA ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-HSA-9609736.5 Assembly and cell surface presentation of NMDA receptors REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9022692.2 Regulation of MECP2 expression and activity ACTIVATION OF INFLAMMATORY CASPASES%REACTOME%R-HSA-9686114.3 Activation of inflammatory caspases DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.4 Defective SLC5A2 causes renal glucosuria (GLYS1) SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-HSA-174113.5 SCF-beta-TrCP mediated degradation of Emi1 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 97%9717319 brigatinib-resistant ALK mutants ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 97%428643 Organic anion transport by SLC5 17 25 transporters DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 97%8939902 Regulation of RUNX2 expression and activity RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 97%2500257 Resolution of Sister Chromatid Cohesion AZATHIOPRINE ADME%REACTOME%R-HSA-9748787.3 Azathioprine ADME SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 97%2555396 Mitotic Metaphase and Anaphase DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME%R-HSA-9858328.1 OADH complex synthesizes glutaryl-CoA from 2-OA ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 97%380994 ATF4 activates genes in response to endoplasmic reticulum stress UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%438066 Unblocking of NMDA receptors, glutamate binding and activation DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 97%4687000 Defective MPDU1 causes CDG-1f BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME%R-HSA-352238.4 Breakdown of the nuclear lamina DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.3 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 97%5621575 CD209 (DC-SIGN) signaling TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 97%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9679504.6 Translation of Replicase and Assembly of the Replication Transcription Complex SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 97%176187 Activation of ATR in response to replication stress TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8864260.5 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-HSA-75953.4 RNA Polymerase II Transcription Initiation DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.5 DNA Damage Telomere Stress Induced Senescence DNA DOUBLE-STRAND BREAK REPAIR%REACTOME%R-HSA-5693532.5 DNA Double-Strand Break Repair NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 97%181430 Norepinephrine Neurotransmitter Release Cycle PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling PHOSPHORYLATION OF THE APC C%REACTOME DATABASE ID RELEASE 97%176412 Phosphorylation of the APC C SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME%R-HSA-9827857.2 Specification of primordial germ cells CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-HSA-1236978.5 Cross-presentation of soluble exogenous antigens (endosomes) PORPHYRIN METABOLISM%REACTOME%R-HSA-189445.3 Porphyrin metabolism REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME DATABASE ID RELEASE 97%9845323 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 97%190241 FGFR2 ligand binding and activation REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 97%5656169 Termination of translesion DNA synthesis SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 97%168271 Transport of Ribonucleoproteins into the Host Nucleus DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.5 Defective EXT2 causes exostoses 2 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 97%5696394 DNA Damage Recognition in GG-NER METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 97%8953854 Metabolism of RNA RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME%R-HSA-9665233.3 Resistance of ERBB2 KD mutants to trastuzumab GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702590.2 gilteritinib-resistant FLT3 mutants FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 97%69183 Processive synthesis on the lagging strand TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.3 Clostridium neurotoxicity RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME DATABASE ID RELEASE 97%167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HS-GAG DEGRADATION%REACTOME%R-HSA-2024096.6 HS-GAG degradation DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME DATABASE ID RELEASE 97%4720475 Defective ALG3 causes CDG-1d POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%8957275 Post-translational protein phosphorylation CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME DATABASE ID RELEASE 97%9833576 CDH11 homotypic and heterotypic interactions APOPTOTIC EXECUTION PHASE%REACTOME%R-HSA-75153.6 Apoptotic execution phase BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME DATABASE ID RELEASE 97%1368108 BMAL1:CLOCK,NPAS2 activates circadian expression INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%9020702 Interleukin-1 signaling NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764260 Regulation of Expression and Function of Type II Classical Cadherins DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%5663202 Diseases of signal transduction by growth factor receptors and second messengers ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 97%2473224 Antagonism of Activin by Follistatin COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 97%2028269 Signaling by Hippo ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.5 Activation of Na-permeable kainate receptors ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 97%1566948 Elastic fibre formation MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 97%1362409 Mitochondrial iron-sulfur cluster biogenesis NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.2 RUNX3 Regulates Immune Response and Cell Migration CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME%R-HSA-163765.7 ChREBP activates metabolic gene expression REGULATION OF NF-KAPPA B SIGNALING%REACTOME%R-HSA-9758274.2 Regulation of NF-kappa B signaling ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%450341 Activation of the AP-1 family of transcription factors DEGRADATION OF CRY AND PER PROTEINS%REACTOME DATABASE ID RELEASE 97%9932298 Degradation of CRY and PER proteins EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 97%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) MRNA POLYADENYLATION%REACTOME%R-HSA-9770562.2 mRNA Polyadenylation HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME%R-HSA-9665244.2 Resistance of ERBB2 KD mutants to sapitinib PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210990 PECAM1 interactions GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 97%5579009 Defective CYP11B2 causes CMO-1 deficiency DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 97%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 97%392518 Signal amplification DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 97%189085 Digestion of dietary carbohydrate GABA B RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977444 GABA B receptor activation LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME DATABASE ID RELEASE 97%9865125 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8941855 RUNX3 regulates CDKN1A transcription DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 97%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 97%199991 Membrane Trafficking SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 97%449147 Signaling by Interleukins TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors LGK974 INHIBITS PORCN%REACTOME DATABASE ID RELEASE 97%5340573 LGK974 inhibits PORCN ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 97%964739 N-glycan trimming and elongation in the cis-Golgi REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression MITOCHONDRIAL TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 97%5368286 Mitochondrial translation initiation FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation INTERLEUKIN-23 SIGNALING%REACTOME%R-HSA-9020933.3 Interleukin-23 signaling MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME DATABASE ID RELEASE 97%5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 97%76046 RNA Polymerase III Transcription Initiation NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 97%194441 Non-coding RNA Metabolism PI METABOLISM%REACTOME DATABASE ID RELEASE 97%1483255 PI Metabolism P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME DATABASE ID RELEASE 97%9723905 Loss of function of TP53 in cancer due to loss of tetramerization ability SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.2 SWI SNF chromatin remodelers TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME%R-HSA-69273.10 Cyclin A B1 B2 associated events during G2 M transition METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.3 Metallothioneins bind metals RHOG GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9013408 RHOG GTPase cycle PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 97%70688 Proline catabolism MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 97%9937383 Mitochondrial ribosome-associated quality control UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.5 Uptake and actions of bacterial toxins DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 97%4641258 Degradation of DVL CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 97%373076 Class A 1 (Rhodopsin-like receptors) DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) MUCOPOLYSACCHARIDOSES%REACTOME DATABASE ID RELEASE 97%2206281 Mucopolysaccharidoses NEGATIVE REGULATION OF DNA DOUBLE STRAND BREAK RESPONSE%REACTOME%R-HSA-9974237.1 Negative Regulation of DNA Double Strand Break Response SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME DATABASE ID RELEASE 97%9660537 Signaling by MRAS-complex mutants MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.5 Terminal pathway of complement DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME%R-HSA-5619063.4 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 97%74160 Gene expression (Transcription) ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.5 Activation of BIM and translocation to mitochondria SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 97%112412 SOS-mediated signalling AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 97%156587 Amino Acid conjugation BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 97%9912481 Branched-chain ketoacid dehydrogenase kinase deficiency REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 97%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 97%9664420 Killing mechanisms TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 97%9702636 tandutinib-resistant FLT3 mutants INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida MMR%REACTOME DATABASE ID RELEASE 97%5358508 MMR BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 97%5602498 MyD88 deficiency (TLR2 4) DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) RET SIGNALING%REACTOME%R-HSA-8853659.7 RET signaling DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME%R-HSA-5619083.3 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) WAX BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%9640463 Wax biosynthesis O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 97%913709 O-linked glycosylation of mucins PHASE 3 - RAPID REPOLARISATION%REACTOME%R-HSA-5576890.5 Phase 3 - rapid repolarisation EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME DATABASE ID RELEASE 97%9833109 Evasion by RSV of host interferon responses ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 97%8866907 Activation of the TFAP2 (AP-2) family of transcription factors EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 97%9914274 3-methylglutaconic aciduria DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 97%5083630 Defective LFNG causes SCDO3 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.3 FCERI mediated Ca+2 mobilization FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 97%444473 Formyl peptide receptors bind formyl peptides and many other ligands INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME DATABASE ID RELEASE 97%8854521 Interaction between PHLDA1 and AURKA MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.7 Mitochondrial Fatty Acid Beta-Oxidation ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 97%1169091 Activation of NF-kappaB in B cells GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA DEFECTIVE DOLK CAUSES CDG-1M%REACTOME DATABASE ID RELEASE 97%4755583 Defective DOLK causes CDG-1m ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.4 Acyl chain remodelling of PI IFNG SIGNALING ACTIVATES MAPKS%REACTOME%R-HSA-9732724.1 IFNG signaling activates MAPKs STRIATED MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 97%390522 Striated Muscle Contraction DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 97%5632928 Defective Mismatch Repair Associated With MSH2 GSD IV%REACTOME DATABASE ID RELEASE 97%3878781 GSD IV ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 97%162791 Attachment of GPI anchor to uPAR CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.7 Cellular hexose transport PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 97%68882 Mitotic Anaphase NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 97%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 97%375276 Peptide ligand-binding receptors STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 97%1834941 STING mediated induction of host immune responses SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 97%4551638 SUMOylation of chromatin organization proteins THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.10 The NLRP3 inflammasome MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 97%2206290 MPS IV - Morquio syndrome A TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME DATABASE ID RELEASE 97%9844594 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 97%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 97%9709275 Impaired BRCA2 translocation to the nucleus DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 97%5579014 Defective CYP27B1 causes VDDR1A FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%R-HSA-164939.5 Nef mediated downregulation of CD28 cell surface expression VISUAL PHOTOTRANSDUCTION%REACTOME DATABASE ID RELEASE 97%2187338 Visual phototransduction DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 97%9035034 RHOF GTPase cycle LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME DATABASE ID RELEASE 97%9022538 Loss of MECP2 binding ability to 5mC-DNA TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME DATABASE ID RELEASE 97%9843743 Transcriptional regulation of brown and beige adipocyte differentiation MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 97%453274 Mitotic G2-G2 M phases PHOSPHO-PLA2 PATHWAY%REACTOME DATABASE ID RELEASE 97%111995 phospho-PLA2 pathway INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 97%210991 Basigin interactions HEME BIOSYNTHESIS%REACTOME%R-HSA-189451.5 Heme biosynthesis HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME%R-HSA-9856530.2 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.10 Glyoxylate metabolism and glycine degradation CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 97%8856828 Clathrin-mediated endocytosis TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 97%8986944 Transcriptional Regulation by MECP2 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 97%2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation NEURONAL SYSTEM%REACTOME DATABASE ID RELEASE 97%112316 Neuronal System TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.7 Translocation of ZAP-70 to Immunological synapse DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 97%110357 Displacement of DNA glycosylase by APEX1 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 97%110330 Recognition and association of DNA glycosylase with site containing an affected purine REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 97%193692 Regulated proteolysis of p75NTR REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 97%4641263 Regulation of FZD by ubiquitination SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions SIGNALING BY NUCLEAR RECEPTORS%REACTOME DATABASE ID RELEASE 97%9006931 Signaling by Nuclear Receptors G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription ABACAVIR ADME%REACTOME%R-HSA-2161522.5 Abacavir ADME DISEASES OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 97%9675126 Diseases of mitotic cell cycle TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 97%201681 TCF dependent signaling in response to WNT ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 97%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME DATABASE ID RELEASE 97%69656 Cyclin A:Cdk2-associated events at S phase entry ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 97%983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME DATABASE ID RELEASE 97%4839743 Signaling by CTNNB1 phospho-site mutants GSD IB%REACTOME DATABASE ID RELEASE 97%3229133 GSD Ib TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME%R-HSA-9025094.3 Biosynthesis of DPAn-3 SPMs HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 97%5467340 AXIN missense mutants destabilize the destruction complex HCN CHANNELS%REACTOME DATABASE ID RELEASE 97%1296061 HCN channels CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress KW2449-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702569.2 KW2449-resistant FLT3 mutants PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.7 Platelet Adhesion to exposed collagen DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 97%187706 Signalling to p38 via RIT and RIN RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX SELENOAMINO ACID METABOLISM%REACTOME%R-HSA-2408522.7 Selenoamino acid metabolism TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME DATABASE ID RELEASE 97%1299287 Tandem pore domain halothane-inhibited K+ channel (THIK) ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME%R-HSA-9026519.2 Activated NTRK2 signals through RAS DEVELOPMENTAL CELL LINEAGES%REACTOME DATABASE ID RELEASE 97%9734767 Developmental Cell Lineages CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME DATABASE ID RELEASE 97%9855142 Cellular responses to mechanical stimuli POLYMERASE SWITCHING%REACTOME%R-HSA-69091.4 Polymerase switching REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 97%5357905 Regulation of TNFR1 signaling FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME DATABASE ID RELEASE 97%399954 Sema3A PAK dependent Axon repulsion CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 97%9940465 ChAHP complex assembly SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.10 Signaling by ERBB2 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME%R-HSA-8948700.2 Competing endogenous RNAs (ceRNAs) regulate PTEN translation ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 97%6803544 Ion influx efflux at host-pathogen interface THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 97%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME%R-HSA-2514853.4 Condensation of Prometaphase Chromosomes DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 97%2172127 DAP12 interactions RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.4 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME DATABASE ID RELEASE 97%9854907 Regulation of MITF-M dependent genes involved in metabolism SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 97%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 97%9652282 Drug-mediated inhibition of ERBB2 signaling ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway PROCESSING OF ANTIGEN IN GERMINAL CENTER B CELLS%REACTOME%R-HSA-9979719.1 Processing of antigen in germinal center B cells REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME DATABASE ID RELEASE 97%210746 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME%R-HSA-9931521.1 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 97%427413 NoRC negatively regulates rRNA expression RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle GASTRULATION%REACTOME DATABASE ID RELEASE 97%9758941 Gastrulation DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 97%4793954 Defective MOGS causes CDG-2b MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 97%9022927 MECP2 regulates transcription of genes involved in GABA signaling SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.6 SLC-mediated transmembrane transport EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 97%2682334 EPH-Ephrin signaling DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 97%6804760 Regulation of TP53 Activity through Methylation PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME DATABASE ID RELEASE 97%69200 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 97%9764274 Regulation of Expression and Function of Type I Classical Cadherins REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 97%165054 Rev-mediated nuclear export of HIV RNA CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 97%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 97%418890 Role of second messengers in netrin-1 signaling UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME DATABASE ID RELEASE 97%69601 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 97%8932506 DAG1 core M1 glycosylations DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development FORMATION OF PARAXIAL MESODERM%REACTOME%R-HSA-9793380.5 Formation of paraxial mesoderm METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 97%8878166 Transcriptional regulation by RUNX2 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME DATABASE ID RELEASE 97%9711123 Cellular response to chemical stress INTERLEUKIN-20 FAMILY SIGNALING%REACTOME%R-HSA-8854691.8 Interleukin-20 family signaling AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME DATABASE ID RELEASE 97%177539 Autointegration results in viral DNA circles SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 97%191859 snRNP Assembly POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME%R-HSA-426496.6 Post-transcriptional silencing by small RNAs FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 97%9935598 FXIIa, PKa activate coagulation factors INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 97%9012546 Interleukin-18 signaling O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 97%5173214 O-glycosylation of TSR domain-containing proteins DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 97%169911 Regulation of Apoptosis ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.3 Acyl chain remodelling of PG RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.4 RNA Polymerase III Transcription Initiation From Type 1 Promoter INDUCTION OF CELL-CELL FUSION%REACTOME DATABASE ID RELEASE 97%9733458 Induction of Cell-Cell Fusion NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME%R-HSA-199418.5 Negative regulation of the PI3K AKT network PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 97%8849472 PTK6 Down-Regulation VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 97%192823 Viral mRNA Translation KINESINS%REACTOME%R-HSA-983189.5 Kinesins NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 97%211859 Biological oxidations NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling SYNTHESIS OF PC%REACTOME%R-HSA-1483191.7 Synthesis of PC LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME DATABASE ID RELEASE 97%168928 DDX58 IFIH1-mediated induction of interferon-alpha beta G1 S DNA DAMAGE CHECKPOINTS%REACTOME DATABASE ID RELEASE 97%69615 G1 S DNA Damage Checkpoints ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 97%2485179 Activation of the phototransduction cascade P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 97%69580 p53-Dependent G1 S DNA damage checkpoint ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 97%418592 ADP signalling through P2Y purinoceptor 1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 97%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol LIPOPHAGY%REACTOME DATABASE ID RELEASE 97%9613354 Lipophagy DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 97%3595177 Defective CHSY1 causes TPBS GABA RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 97%977443 GABA receptor activation ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME%R-HSA-936964.6 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.7 NOTCH1 Intracellular Domain Regulates Transcription TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 97%451306 Ionotropic activity of kainate receptors FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex SIGNALING BY WNT IN CANCER%REACTOME DATABASE ID RELEASE 97%4791275 Signaling by WNT in cancer G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 97%1296059 G protein gated Potassium channels SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME DATABASE ID RELEASE 97%187577 SCF(Skp2)-mediated degradation of p27 p21 RAB GERANYLGERANYLATION%REACTOME%R-HSA-8873719.4 RAB geranylgeranylation COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 97%166658 Complement cascade SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 97%4839735 Signaling by AXIN mutants DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME DATABASE ID RELEASE 97%5619046 Defective SLC26A4 causes Pendred syndrome (PDS) MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates TRANSLATION INITIATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 97%72649 Translation initiation complex formation REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 97%210745 Regulation of gene expression in beta cells SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 97%5655332 Signaling by FGFR3 in disease NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 97%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 97%8951911 RUNX3 regulates RUNX1-mediated transcription MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 97%1221632 Meiotic synapsis REGULATION OF GAP JUNCTION ACTIVITY%REACTOME DATABASE ID RELEASE 97%191650 Regulation of gap junction activity ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME%R-HSA-9634635.4 Estrogen-stimulated signaling through PRKCZ DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 97%5632968 Defective Mismatch Repair Associated With MSH6 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 97%500792 GPCR ligand binding HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 97%2022928 HS-GAG biosynthesis INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 97%2995383 Initiation of Nuclear Envelope (NE) Reformation WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 97%3238698 WNT ligand biogenesis and trafficking ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 97%9034864 Activated NTRK3 signals through RAS PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection DEFECTIVE MPI CAUSES CDG-1B%REACTOME DATABASE ID RELEASE 97%4043916 Defective MPI causes CDG-1b ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 97%2029485 Role of phospholipids in phagocytosis EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 97%209776 Metabolism of amine-derived hormones NEURODEGENERATIVE DISEASES%REACTOME DATABASE ID RELEASE 97%8863678 Neurodegenerative Diseases SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 97%5654688 SHC-mediated cascade:FGFR1 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.4 Activation of anterior HOX genes in hindbrain development during early embryogenesis DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 97%9656256 Defective OGG1 Substrate Processing TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 97%168179 Toll Like Receptor TLR1:TLR2 Cascade INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 97%912526 Interleukin receptor SHC signaling TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 97%3000157 Laminin interactions