ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-HSA-1169091.2 Activation of NF-kappaB in B cells 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 19696 12042 66413 26965 667035 22190 18751 240354 59029 26409 67089 103583 70247 21762 22123 12675 108723 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 18037 26442 69077 66997 23997 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine 117147 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors 22260 20181 22337 19013 56469 13982 22025 19883 11835 18227 14815 59004 20610 208727 19016 22196 100043429 110784 26423 19401 229615 21834 18667 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 96%5685942 HDR through Homologous Recombination (HRR) 20422 667035 22190 52864 19360 27015 69745 17535 21975 19363 19364 27354 12021 224008 60530 81601 327762 269400 59001 19361 114714 209334 22427 19687 19718 69263 15574 11920 66979 12189 12190 235610 231724 237911 19355 57434 225182 74335 26909 18538 235559 71711 12144 381306 68275 106344 72151 18971 68240 18972 233826 19891 18973 18974 80905 19367 19356 19362 67967 268465 12649 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C 52717 99152 668450 12534 217232 56317 59008 18817 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876384 Listeria monocytogenes entry into host cells 12388 12387 58194 12550 20408 12402 56324 20779 15239 20404 17295 20844 20405 13858 104836 667035 22190 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 96%187687 Signalling to ERKs 107746 109880 12929 26416 12928 56044 64143 18049 216148 26413 26417 29857 20416 327826 18211 109905 77480 19094 20418 102626 19730 54401 26415 26395 26396 19762 18176 20662 19769 15461 17164 DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle 217214 11898 109900 227231 18408 18416 67824 11846 HEME SIGNALING%REACTOME DATABASE ID RELEASE 96%9707616 Heme signaling 328572 15129 17087 15368 15122 12013 21372 109151 11806 56760 17977 238055 19017 18143 103573 17135 17978 59035 81004 66993 17260 17261 21898 12753 18024 268903 70461 15183 20185 93759 217166 74343 12914 20181 382056 56406 19013 11909 19883 19014 229003 11865 19377 70804 52466 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 96%1168372 Downstream signaling events of B Cell Receptor (BCR) 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 19696 12042 66413 26965 667035 22190 18751 240354 59029 26409 67089 103583 70247 18176 15461 640703 268373 19055 19056 19419 18018 18019 21762 240168 22123 19058 12675 14225 108723 18021 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 18037 26442 69077 66997 23997 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME%R-HSA-8862803.4 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 14103 12532 12380 12333 12334 12336 20656 56484 16476 69543 18477 21672 16906 22627 12569 12568 11820 99412 12125 12530 12531 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport 100434 213603 242259 75750 70129 68682 63993 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 96%2644605 FBXW7 Mutants and NOTCH1 in Cancer 26965 18128 21402 56438 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373080 Class B 2 (Secretin family receptors) 57265 13733 381853 14607 22226 14697 93897 19206 54598 22412 216795 19226 14710 14699 66066 14700 22410 93896 22414 22411 14708 14706 22409 12310 14704 11516 14695 14652 11517 12311 14693 20423 64337 14709 15874 12921 12919 22417 12918 14701 114640 223780 54409 19227 19228 56089 213527 51801 13363 14602 14601 319757 11535 14702 93735 83428 14696 14527 14526 14367 14365 26364 14362 22415 14366 22413 22416 22420 22418 14370 22354 22422 14371 22421 22353 20287 14368 22423 14369 22355 20890 19207 14688 22408 16147 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70247 18176 15461 26554 226525 18015 320484 211255 240057 101809 54153 114715 21762 114716 22123 19414 69601 19415 19179 218397 19181 114713 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%888568 GABA synthesis 14415 14417 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation 11881 15931 12111 121021 13004 244757 29873 13003 110006 77042 15586 109685 70893 15212 15211 12032 13179 15932 12091 DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle 52717 99152 668450 12575 22589 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 56371 27401 13163 12448 12577 12576 217232 56317 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702596 lestaurtinib-resistant FLT3 mutants 14255 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2500257 Resolution of Sister Chromatid Cohesion 12534 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 218914 12235 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 100710 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 12442 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 71521 13426 52504 13424 228421 20843 381306 18817 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME%R-HSA-9927426.2 Developmental Lineage of Mammary Gland Alveolar Cells 19109 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 96%5423599 Diseases of Mismatch Repair (MMR) 17685 17686 17350 17688 18861 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 96%388479 Vasopressin-like receptors 18429 11998 18430 54140 26361 12000 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 96%1483101 Synthesis of PS 19210 27388 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 96%351906 Apoptotic cleavage of cell adhesion proteins 12367 18772 109620 13512 12387 12550 21873 13511 13510 21872 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 96%2395516 Electron transport from NADPH to Ferredoxin 14149 14148 68165 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9608290 Defective MUTYH substrate processing COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 96%388841 Costimulation by the CD28 family 233833 53859 16451 21415 232440 12387 13200 13626 319149 72297 22628 320207 16478 16842 22612 11651 11652 22324 15077 269523 66310 18710 140858 97064 18566 230979 52615 26410 19646 213464 14360 12988 11910 214162 13001 13000 100039026 17869 245688 20747 12500 22601 12501 12502 15251 17096 23808 12504 18109 244373 18005 17444 78757 228775 60533 76580 108099 16362 30955 18708 18709 18479 12477 18706 18607 328572 74769 18707 66357 12487 12519 12524 21414 21416 231051 18481 18024 12914 16476 56438 26554 12567 12443 73699 19052 19053 51792 226849 225849 26931 21770 26932 21762 22123 19179 19181 19182 23996 19184 18033 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 21679 15267 21676 319168 21678 319167 14281 224105 226144 75778 76850 239528 319186 21677 319178 319183 319182 193670 54197 236511 319190 26754 241113 14282 56717 70377 319176 18034 216440 319181 19353 20014 213988 57261 103963 217351 56637 214150 69038 227743 13135 19247 13819 14969 14968 66753 104709 67819 208154 14056 15170 116891 17454 20338 319169 109270 50723 67075 105787 108079 20846 19079 20848 108097 625328 78303 319188 15270 58205 16818 19082 80286 56716 624153 68292 23797 16430 382522 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 229906 235459 24074 83602 58202 68153 74197 67923 27224 27632 24116 12455 72949 13716 63856 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%190872 Transport of connexons to the plasma membrane 14609 14619 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding 12469 21371 12461 14466 12464 30050 108903 50762 72726 14675 53857 24012 24128 19739 22327 22152 227613 50782 14697 22153 12447 50754 216853 56327 50779 22142 12448 11461 14710 22146 14699 14976 66066 67199 14700 18637 108077 67466 67951 27055 14708 13001 71833 14706 13000 14672 100039026 14447 213980 14704 66411 73710 14695 68628 14676 22145 22059 14693 12465 16553 64337 55946 14709 50789 545486 238463 30839 14682 67134 14701 109054 56612 20698 99371 14702 14696 15183 14688 20848 12466 22147 21454 12462 22151 106052 70430 66887 242960 12467 30838 12468 22143 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins 18141 23825 107939 69482 71805 11739 433923 11740 54563 16646 19069 15361 70699 101739 72787 18226 218210 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 96%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 52717 99152 668450 56150 12237 107995 217232 56317 12236 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) 22589 13163 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 96%113507 E2F-enabled inhibition of pre-replication complex formation 50793 18392 18393 12534 66634 26428 26429 56452 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 96%112303 Electric Transmission Across Gap Junctions 14615 14610 55991 14617 406218 INFLUENZA INFECTION%REACTOME DATABASE ID RELEASE 96%168255 Influenza Infection 622534 238217 74568 16785 666669 100040021 67025 100043391 668182 241053 12317 432502 100038882 19989 76808 19899 100043184 19921 19934 100043755 11545 193740 12330 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 16211 100039592 16648 19106 100037258 19386 100043876 100043893 100043423 100042986 20115 67281 54196 76846 625646 100040298 68172 100042740 19951 381686 16649 70572 19384 667618 100040970 267019 56040 67248 445007 100040331 67941 57294 103573 69912 103468 234865 59015 69736 110379 68705 98053 667035 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 170762 108989 231042 227699 223921 227720 269113 66679 18141 107939 69482 71805 11740 54563 16646 19069 70699 72787 18226 218210 27207 67097 670832 231413 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 21803 20103 668668 667739 54188 67300 672214 12757 66481 225058 100038875 100038991 68028 100043000 67891 100043295 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 96%5633231 Defective ALG14 causes ALG14-CMS 66789 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME%R-HSA-8939245.2 RUNX1 regulates transcription of genes involved in BCR signaling 69257 13709 12143 18507 12400 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism 14104 74450 73095 71743 75735 68087 211347 67618 269614 106564 72621 66812 73132 26464 22361 18605 18606 330064 209558 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides 65221 56643 83429 100561 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript 386612 17149 100040029 19386 170762 108989 231042 227699 223921 227720 445007 269113 66679 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 64340 622469 69912 225027 67996 225160 51796 56488 103468 192160 331401 71713 53817 233073 625193 69823 234865 20382 110809 73666 60365 20383 59015 68278 69736 170722 70579 21681 73826 68134 110379 66231 66511 107829 108014 53319 192170 69207 19826 193116 74412 66441 FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9832991 Formation of the posterior neural plate 14472 24136 225207 18991 18424 20664 14179 21389 20674 22416 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis 22099 236511 214150 192119 76850 23992 239528 53424 21357 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels 225997 22063 193034 22065 22067 22066 28240 22068 63873 171382 171166 56407 68667 277328 64177 17364 246788 68279 94178 22368 226025 194352 26946 56843 58800 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells 16775 16776 16777 16779 16780 226519 14268 16782 16772 23928 16773 16774 22370 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME%R-HSA-164940.5 Nef mediated downregulation of MHC class I complex cell surface expression 252903 15007 12010 11768 11769 108012 11764 107975 11765 11767 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 52150 16525 16530 PROTEASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9907900 Proteasome assembly 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 59029 67089 70247 69666 16912 19171 107047 66537 19185 19192 73902 66998 56088 67151 53380 66506 16913 228769 103554 19186 19188 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 12042 66413 26965 667035 22190 240354 59029 26409 67089 103583 70247 17096 18607 100041766 216150 66513 93765 66589 18761 22034 19395 66724 233046 68652 19419 21762 22123 12675 108723 19179 19181 19182 23996 19184 18033 26440 19166 216080 18035 19167 26441 26442 69077 66997 23997 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9856649.3 Transcriptional and post-translational regulation of MITF-M expression and activity 21943 17342 20665 20682 18992 12387 15901 209446 12550 17202 107508 22628 17201 21425 20674 16842 26413 26417 54401 22196 328572 103573 22416 56637 93759 12914 21426 20583 20111 107045 226414 97541 17169 216443 18505 22631 13616 22629 105148 15254 231872 13614 66143 22771 18976 17199 433759 13618 16590 22627 15221 12977 104458 11694 21386 23797 85305 17203 13722 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209968 Thyroxine biosynthesis 13371 13370 70337 12389 213696 114479 107585 22094 214593 99439 66811 106200 12640 22018 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 96%9748787 Azathioprine ADME 22325 214254 13340 269346 15452 22017 63959 100042069 14863 23917 14923 57257 19353 22324 18102 18103 229363 27416 239273 114304 22436 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle 26891 56320 12461 109711 12539 20462 69288 242202 15519 51796 26554 53817 246710 50875 19877 15381 83946 106504 109331 11465 12466 12848 19230 17920 22352 19878 76626 56381 19655 53382 15516 12468 100043806 269061 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA 12544 69270 66634 109145 17216 272551 17215 17217 17218 17219 17220 78833 NGF PROCESSING%REACTOME DATABASE ID RELEASE 96%167060 NGF processing 18552 18550 18553 18049 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer 21803 21812 21813 MTOR SIGNALLING%REACTOME%R-HSA-165159.9 MTOR signalling 233833 11651 11652 54401 108099 76850 239528 236511 241113 56717 213988 217351 214150 12283 20869 64930 13631 75705 66508 545987 13685 13684 18655 54170 72149 208643 22084 52187 17454 68576 66096 83409 74370 68441 19042 105787 268706 14225 108079 69008 67605 19079 227154 245670 108097 667739 19082 56716 23797 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 96%5579007 Defective ACY1 causes encephalopathy 109652 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 96%168799 Clostridium neurotoxicity 56216 20980 64176 22317 64051 22318 20614 20979 20907 75209 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME%R-HSA-5467333.3 APC truncation mutants are not K63 polyubiquitinated 11789 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters 20505 142681 20531 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME DATABASE ID RELEASE 96%5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) 16151 12675 16150 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 96%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 73166 231070 270669 110196 14137 100040592 20683 66397 18044 18045 18046 235293 68603 69608 218811 14732 99683 20775 20249 235623 192156 170439 72999 13121 20788 13360 107476 100705 14593 16987 17764 56453 77371 20181 319554 16211 17855 19013 20334 19384 19014 229003 14104 21372 109151 17977 17978 59035 81004 66993 12914 56406 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 96%451308 Activation of Ca-permeable Kainate Receptor 110637 640703 14807 14806 13385 14805 52589 53310 13383 14809 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME DATABASE ID RELEASE 96%8875360 InlB-mediated entry of Listeria monocytogenes into host cell 20405 13858 58194 667035 22190 20408 12402 56324 15239 20404 17295 20844 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E 667035 22190 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5218859 Regulated Necrosis 14103 74568 12367 667035 22190 15519 22059 66371 14939 14102 68953 16176 75608 12362 14251 18571 12363 22195 22035 16362 50873 16396 208092 12370 66700 19766 11797 56532 670717 14252 12539 16173 22030 108155 16363 56424 21933 67245 69146 11796 11798 12018 50701 22061 53378 105513 16175 12028 54722 434174 71609 14082 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 96%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) 20520 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%8866376 Reelin signalling pathway 58194 22359 19699 13131 14360 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 96%8949613 Cristae formation 227112 17827 57423 68653 66477 76614 224904 11958 11957 68117 230935 216821 11947 66075 11949 433771 68055 68316 17705 11946 15526 66098 66043 11950 53375 100041835 100039108 432676 228033 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-HSA-110314.5 Recognition of DNA damage by PCNA-containing replication complex 76843 59001 19687 19718 56438 69263 66979 667035 22190 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 67967 99375 69745 22210 72584 58186 230484 13194 67561 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%5578775 Ion homeostasis 269717 11931 14226 11932 11933 11937 11938 65973 53313 109305 56188 76757 16514 109552 67972 11941 320707 381290 22063 12322 12323 108058 12325 20192 20191 20866 110891 20190 229709 16438 16439 13400 18747 11928 98660 232975 640703 20541 57780 18125 110893 16440 59095 20928 108017 21954 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects 52717 99152 668450 19645 217232 56317 59008 66156 56371 216080 27401 69957 17222 75430 68612 52563 22194 68999 52206 100039535 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559583 Cellular Senescence 52717 233833 99152 668450 232440 15901 12575 13626 319149 211586 13555 19645 21781 12571 12567 12566 15077 13557 12447 242705 56371 26416 12448 52615 12576 19646 26413 26417 19094 245688 102626 110651 20112 12418 15364 665113 17164 28113 77683 101185 15260 22166 29817 75560 56702 50709 14957 50708 14958 12151 26408 17248 17165 19763 80838 66403 12428 17246 54383 13619 110147 26399 57321 26400 241915 12416 26398 26420 26414 26397 13875 319152 104248 19821 21749 497652 21750 23939 100043858 12580 216850 12579 12578 16193 23872 23871 50932 26921 494448 15977 26419 12427 170644 12608 30951 16476 18033 16906 20683 19697 667035 22190 22059 15267 319168 319167 14281 19360 17535 76850 319186 27354 319178 319183 319182 81601 236511 319190 15361 319176 11920 319181 213988 16175 217351 214150 14056 20111 17454 319169 20848 217232 56317 625328 59008 78303 319188 66156 15270 216080 69957 17222 75430 68612 52563 624153 22194 68999 52206 100039535 382522 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 12448 12577 12576 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 96%9006115 Signaling by NTRK2 (TRKB) 327826 20779 12064 14812 18176 14388 20662 21844 19353 18212 15461 208869 18205 107971 78405 18803 12569 12568 18708 19247 18706 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes 12914 328572 20683 11839 12043 18024 18590 13645 12048 18128 17135 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 13629 68028 67160 100043000 66656 67891 55949 100043295 13628 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) 22084 64930 23797 11651 11652 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2691230.3 Signaling by NOTCH1 HD Domain Mutants in Cancer 18011 13388 16449 240055 225164 11487 54485 11491 16450 18128 667035 76580 22190 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%389357 CD28 dependent PI3K Akt signaling 74769 53859 18707 12487 12519 12524 320207 56717 11651 11652 18710 227743 26410 14360 104709 109270 78757 228775 16818 30955 56716 18708 75778 18709 23797 18706 18607 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 96%191859 snRNP Assembly 18141 107939 69482 71805 54563 107686 384091 19069 666609 68092 216766 70699 66069 621705 72787 20595 433702 18226 66603 218210 53975 12729 276919 20641 27374 20638 56698 70465 69731 432803 67332 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives 19225 11689 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels 20928 16514 16523 20927 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 96%174577 Activation of C3 and C5 15139 14962 12263 12266 625018 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion 14917 11722 76768 12613 14916 69060 18946 109791 18947 58866 69983 67717 232714 69656 14915 81600 71884 226413 100043686 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP 13665 67204 108067 217715 26905 13667 209354 224045 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69580.5 p53-Dependent G1 S DNA damage checkpoint 56436 17463 57296 20422 26445 26446 12575 19172 19173 19175 19177 26443 26444 12566 19170 12447 66413 667035 22190 12448 59029 12576 67089 70247 22059 17248 29813 59092 26374 50883 228829 12428 17246 11920 12578 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 96%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) 229782 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity 12013 26965 50758 27401 667035 22190 21402 56438 17135 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids 103098 53896 56774 242607 14411 30962 20532 215113 67760 50934 209837 20513 21366 20514 215335 11989 234967 55963 69354 74338 76257 20511 20510 102680 20512 20540 330836 72401 246049 17254 11987 214663 105727 20539 26570 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein 71164 53618 66357 20448 227619 19089 13200 208884 20014 103963 12330 69038 13135 103534 57377 67075 27801 228136 75965 70546 108687 269181 57437 217664 69035 107895 20446 20444 20442 20443 80286 17308 17158 20440 68292 67569 14376 16430 20447 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 96%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 640703 12326 14811 13385 18039 14810 53310 11472 13383 320472 23859 14812 14814 68606 52163 14813 12322 12323 108058 12325 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response 16193 217344 20620 93671 18550 16153 17886 26416 11491 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 96%168316 Assembly of Viral Components at the Budding Site 12330 12317 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%9645460 ALPK1 signaling pathway 68652 71481 667035 211550 22190 66513 26409 22034 66724 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex 52717 99152 668450 56150 12237 107995 217232 56317 12236 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway 20682 12389 12640 18550 20869 64930 66508 545987 54170 22084 52187 68576 66096 83409 74370 68441 19042 268706 245670 20683 18044 18045 18046 14732 14102 12362 16396 670717 56424 21933 22061 12028 12322 12323 108058 12325 18747 12418 77683 22166 12151 17248 17165 19763 12428 17246 54383 13619 110147 26399 241915 12416 19821 12579 12578 16193 494448 12427 12608 30951 12064 14812 13388 16449 27374 29813 59092 50883 228829 12326 14811 20620 70625 68975 13865 243963 234959 12419 21418 76184 94112 15213 67268 70208 17988 21849 69020 13649 21802 14723 55948 94093 228876 15111 67731 268417 14751 23942 209225 56771 50493 21825 80509 104625 22160 21815 67911 214669 226896 240068 13395 108083 21833 15257 13038 77827 18983 98386 13039 210104 384763 239985 72611 269704 12702 14462 16854 14461 228839 14460 71361 14463 16477 233107 14776 56310 72780 237775 208043 26896 14800 15258 218772 19411 103988 52897 75747 80707 54526 16880 14534 17700 244556 12857 110109 619310 12450 12452 69131 30944 237758 53621 110323 19664 72068 14579 12861 232791 19650 17863 19651 12862 17865 12868 68943 66142 216848 232232 12866 12865 233056 100041785 208836 77519 109648 18129 18131 170936 18132 107932 666581 12662 675812 72119 243834 170787 18148 53376 19211 333182 22775 239546 230899 75605 68428 16184 216456 16183 434377 66494 110052 100039786 19712 19713 71131 619331 26992 243906 15510 22648 381549 71063 319974 68742 235682 68094 83796 83797 57376 72720 19246 243743 244713 544922 380975 72306 268936 229542 434178 22658 12705 22750 17684 23988 67279 19258 72154 59027 67057 225872 17283 17992 69076 18718 18741 74400 15228 56353 230162 72723 22704 14229 22757 226830 70315 21349 210135 93836 193452 11864 67821 244349 80902 13866 13864 74747 210503 93681 57264 232784 330301 74120 18519 449521 245368 15370 109594 17702 22654 16909 11783 56707 16825 57745 69562 242109 64384 22761 30942 15378 195522 77044 18534 103836 22632 20750 269870 12020 20393 20375 22696 18854 245595 56314 353187 70227 79221 110616 11816 59024 327987 72180 236193 432769 66105 67296 52712 231866 233904 22294 20135 234725 192292 83766 80751 23957 21907 11350 20482 74570 20481 20183 20182 71041 75410 101095 238690 17125 17126 17127 17128 69181 75692 76073 17192 12741 66313 17130 21981 17131 17132 228140 67235 268859 56744 103806 56525 14312 16600 70088 13496 53325 69125 22640 209456 11604 219024 228491 219103 333639 22284 56456 18124 66813 53892 22062 319801 213011 223272 99890 69790 22678 68527 58184 19885 243372 22026 225998 52679 50496 22608 13559 104394 241764 12858 93760 233893 66923 107986 353310 76390 21762 13198 22123 14634 13197 14633 19179 57748 19181 14660 19182 67956 23996 268973 19184 75788 18033 230784 26440 16653 19166 170826 20463 19167 170574 12981 26441 12978 74352 26442 64050 69077 76367 66997 381022 23997 69260 14381 56436 14377 17463 78893 57296 19293 20422 70472 26445 16334 26446 327963 19172 69228 19173 225655 19175 56458 19697 239652 19177 52846 21402 94223 78251 26443 21388 26444 18091 332937 19170 21423 231464 232854 66413 22709 26965 16179 667035 18387 22190 18390 18751 64058 240064 59029 21408 13983 67089 75613 14219 70247 21406 68744 22260 17708 20181 17709 22337 17710 19013 22693 16408 13982 12795 22025 14431 19883 26913 11835 72739 18227 72556 14815 26381 272347 26380 208727 26379 19016 57913 22196 16399 12366 16401 26423 16402 19401 106931 12368 21834 20787 18667 233060 69234 19360 56338 13831 264064 17535 12053 21975 12359 18022 19364 84682 27354 15978 12021 12843 12842 20807 81601 56187 327762 54601 19352 17386 19361 330463 170740 243621 22427 333654 12399 19718 192651 69263 20371 15574 20604 11920 16009 16006 12189 83814 22689 235610 68036 231724 12227 237911 15185 19355 12122 66262 225182 12142 15184 26909 22751 18538 27274 235559 11863 17433 12144 20527 216154 68275 20467 106344 78783 72151 211651 14088 68240 51813 12156 252870 19891 72230 15469 212712 12177 19367 69792 19356 12417 15205 20878 20466 12649 108961 217232 18996 56317 18997 59008 67381 19015 66156 72805 216080 12905 69957 219022 17222 22339 75430 56222 68612 666311 52563 15182 22194 71393 68999 15194 52206 12226 100039535 319530 52717 244219 99152 22690 668450 17187 12534 100041581 56275 12387 20602 11906 23989 67155 20586 170753 20779 20588 20587 56461 17295 60599 67338 270118 235956 13345 21936 241196 235028 26416 433766 66214 12005 29808 16656 234366 26413 18787 26417 240087 77976 12545 107568 67370 28077 56233 19094 234594 382985 15214 244216 54401 171285 21420 21419 19014 11865 328572 21372 19017 103573 59035 81004 66993 17260 15183 20185 93759 217166 12914 11909 640703 18019 20656 56484 16476 18477 21672 22627 12569 12568 12125 14103 12532 18128 56438 12918 16147 14415 14417 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 12447 56371 27401 13163 12448 12576 73699 11799 19052 19053 51792 20877 26931 18861 17685 17350 21872 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 20924 23894 14884 21679 15267 21676 319168 21678 319167 14281 76850 239528 319186 21677 319178 319183 319182 236511 319190 241113 56717 319176 319181 213988 217351 56637 214150 227743 19247 14056 17454 319169 109270 105787 108079 20846 19079 108097 625328 78303 319188 15270 19082 56716 624153 23797 382522 233833 21415 232440 13626 319149 22628 16842 22612 11651 11652 15077 66310 140858 97064 52615 19646 213464 214162 13001 13000 100039026 17869 245688 22601 23808 78757 108099 12477 18607 21414 21416 231051 270627 228980 319944 21374 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 24074 58202 67923 27224 27632 24116 12455 72949 13716 63856 22059 21803 11545 69257 13709 12143 18507 12400 225207 20674 22065 18761 22631 22629 18976 433759 16590 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF 16706 20779 12322 109880 12323 108058 12325 26413 26417 12988 109905 640703 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 16653 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins 16993 15446 11689 XENOBIOTICS%REACTOME DATABASE ID RELEASE 96%211981 Xenobiotics 13087 13107 13106 622127 11624 11622 72303 107141 13088 13077 56448 13076 13114 74134 72082 13110 13113 545817 11863 11864 IRON UPTAKE AND TRANSPORT%REACTOME%R-HSA-917937.6 Iron uptake and transport 71902 59049 73649 21402 26965 667035 22190 68428 94178 52466 15368 11428 18174 242341 68775 53945 15369 30926 76252 11972 108664 66290 67634 18002 14325 117167 11964 26357 110935 11966 100039636 66335 11973 11974 15203 74915 14319 338375 21871 73834 12870 114143 66237 11975 22041 54411 27060 64602 16819 242960 140494 22042 50765 15216 66144 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 96%69017 CDK-mediated phosphorylation and removal of Cdc6 52717 56436 99152 17463 668450 57296 23834 20422 26445 26446 19172 19173 19175 19177 26443 26444 12566 19170 12447 66413 56371 667035 22190 12448 59029 67089 70247 12428 12427 21762 22123 19179 19181 19182 217232 23996 56317 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-HSA-1606341.4 IRF3 mediated activation of type 1 IFN 56480 446099 54131 207521 58203 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers 110895 20544 226999 236794 331004 77031 236727 105243 277973 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 96%1234158 Regulation of gene expression by Hypoxia-inducible Factor 12914 328572 13856 17684 230099 22339 15251 11863 13819 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency 12040 12041 13171 13382 12039 COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-HSA-8948216.4 Collagen chain trimerization 12843 12832 12842 12817 12816 12815 12814 12831 12813 94216 12830 373864 12821 107581 77018 12819 53867 12829 12828 12827 12826 12825 69700 12824 12822 71355 12841 12823 73368 12840 213945 12818 245026 140709 237759 12839 329941 12837 12836 12835 12834 12833 LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism 270669 66397 11816 667035 22190 56453 22260 18747 16891 100017 30924 68453 103161 93835 100102 57875 11806 67963 11307 105847 238055 22259 18453 16956 65969 11303 11771 18552 11772 18550 66113 18553 71770 232345 13909 218203 320024 22359 223920 11657 11807 11808 18145 20652 16816 17777 56636 624219 15450 76483 232910 11773 11812 16835 11813 11814 11425 110611 27801 208677 54135 18749 171504 16889 67300 12757 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953080 MPS VII - Sly syndrome (CS DS degradation) 110006 NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration 15926 11428 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 96%71387 Carbohydrate metabolism 72297 27416 14751 103988 18655 640703 20544 14447 170762 108989 231042 227699 223921 227720 269113 66679 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 18749 68961 29873 338362 13003 76969 110006 74637 77042 328779 15586 23971 109685 23972 70893 319415 15212 78923 15211 11676 12032 18682 13179 14387 18534 15932 11677 12091 18295 11881 76898 15931 68631 12111 212898 121021 14385 13004 114332 244757 56043 66646 14595 15277 15275 17022 78752 75612 192188 50935 60322 269941 108902 80908 218271 14264 105193 14121 19746 545291 14120 70484 110078 110095 19309 23908 15529 18747 23888 20971 14635 74246 319625 224674 19386 20969 14422 73699 54613 56398 14430 15587 216558 216019 15442 50917 16548 19052 71951 20970 19053 19139 51792 54371 66171 71797 14735 12505 268512 100043349 71336 445007 231583 53412 75456 19895 235582 212032 21770 14043 14042 15531 226265 15530 77559 110639 13521 27419 73836 56336 56386 13806 103978 18563 235504 74241 66681 54616 16770 58193 80982 14733 21991 53374 83398 50786 69912 17160 13808 77590 13807 108652 103468 93683 13853 68401 231727 20525 14734 116847 234865 20322 319901 64580 117592 67883 59015 59031 69736 57370 53418 21351 56375 215015 110379 26878 26877 54218 50787 270198 18641 73744 18642 26384 12183 14378 14381 18639 14377 18640 170768 102448 18648 56012 14348 15366 21881 70974 15118 15117 15116 17159 56421 72136 110173 58250 18663 54710 628779 235534 667035 225913 22190 67980 50785 232493 14936 74185 27357 74468 110208 74551 11603 16545 233781 217119 227327 67880 14345 231103 53625 14344 14343 93961 11668 15476 72157 15478 27029 195646 17423 14347 280645 18679 56773 110094 102093 72727 234356 232449 27047 58810 11674 72141 230163 20444 20442 20443 INACTIVATION OF CDC42 AND RAC1%REACTOME DATABASE ID RELEASE 96%428543 Inactivation of CDC42 and RAC1 19353 19876 259302 223666 20563 14270 117600 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling 18212 18205 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 17087 56480 667035 21898 22190 12475 22031 56489 225471 106759 21353 71648 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 96%71384 Ethanol oxidation 11529 68738 11522 26876 11532 11669 11668 60525 72535 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 96%9706377 FLT3 signaling by CBL mutants 14256 667035 22190 12402 14255 DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9657050 Defective OGG1 Localization TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 216848 12865 17977 19017 107932 70673 22227 12683 12686 94187 19646 234366 116871 12162 51810 116870 13592 20181 19013 245688 17125 19016 17128 23942 17192 433759 170826 15182 229542 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins 16151 106021 229615 19106 18035 56489 19697 59004 20610 18034 22196 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage 75894 18950 229665 15452 109674 11717 105446 11534 11486 11821 66355 13178 27369 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 96%5679096 Defective ABCG5 causes sitosterolemia 67470 27409 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 96%9683701 Translation of Structural Proteins 20448 19089 56637 12330 667035 22190 57377 22196 14423 214424 328417 606496 67287 80285 52552 20446 671535 20444 547253 20442 20443 17308 20440 14376 20447 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway 233833 18796 18797 14686 21415 18795 14681 12387 16842 57265 14697 12322 14710 14699 26409 66066 14700 16438 16439 22411 14708 14706 14704 14695 16440 14693 64337 14709 14701 76850 239528 14702 14696 236511 21414 21416 14367 14365 14366 22418 213988 217351 214150 14368 14688 640703 19055 17454 19056 18018 19058 225600 18750 19091 19092 18587 18588 18099 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 22632 328572 12705 17684 70472 12575 11816 18741 332937 18148 233107 12640 75605 21418 12914 13866 110052 80707 17869 13982 13649 21802 21420 15510 110109 21419 22196 106931 16590 22339 56222 17865 226896 64050 DEFECTIVE MAOA CAUSES BRUNS%REACTOME DATABASE ID RELEASE 96%5579012 Defective MAOA causes BRUNS 17161 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9700645 ALK mutants bind TKIs 14268 18148 67300 78798 268980 13666 215114 12211 19043 19084 14025 11682 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70688 Proline catabolism 56189 212647 19125 DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 96%73928 Depyrimidination 319178 319183 319182 232440 319190 57321 319176 319181 17193 234258 71726 319152 382913 18294 21749 72774 497652 18207 21750 319169 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME%R-HSA-168273.5 Influenza Viral RNA Transcription and Replication 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 11545 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 100037258 19386 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 70572 667618 100040970 267019 56040 67248 445007 100040331 67941 57294 69912 103468 234865 59015 69736 110379 68705 98053 667035 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 170762 108989 231042 227699 223921 227720 269113 66679 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 27207 67097 670832 231413 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) 56324 15239 20844 105513 667035 22190 107305 72543 27681 70160 194309 52348 116733 73711 22088 67123 330192 28084 76959 66201 20479 66914 66371 68953 75608 208092 66700 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 96%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 328572 19763 12400 54383 67155 67057 13619 239985 20586 20588 20587 241915 56456 12416 56353 66993 19821 15258 83766 13001 13000 100039026 494448 93760 66923 30951 319974 12418 68094 76073 83796 83797 57376 77044 12151 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.3 Mitochondrial translation elongation 64658 66419 64660 78523 94061 623346 102060 50529 233870 100040519 68565 99045 66973 69163 52443 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 67681 66399 64655 107733 68537 18100 67707 94066 60441 218506 66230 68463 65111 74600 107734 66242 28028 68735 622268 27398 94067 28030 67840 68836 79044 94065 57312 75398 68572 67308 64659 56282 66292 24030 66121 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.5 G1 S DNA Damage Checkpoints 12234 93687 56436 208583 17463 57296 20422 26445 26446 12575 19172 19173 19175 19177 21402 56438 26443 26444 12566 19170 12447 66413 26965 667035 26416 22190 12448 59029 12576 67089 103583 70247 19094 12795 22059 17248 29813 59092 26374 50883 228829 12428 17246 11920 56637 12578 12427 21762 22123 19179 19181 12649 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 12530 23997 27373 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16456 18762 11848 102098 70737 93742 56513 14225 21803 75788 21812 667035 21813 22190 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function 12057 VIRAL MESSENGER RNA SYNTHESIS%REACTOME%R-HSA-168325.6 Viral Messenger RNA Synthesis 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 68705 98053 66420 69833 67710 245841 69920 20022 69912 20020 231329 20021 103468 69241 17749 100043714 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 96%5621575 CD209 (DC-SIGN) signaling 18747 328572 12914 18481 19697 19698 15896 17096 73086 18176 170786 18749 15461 110157 18033 224105 18479 14360 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E 68146 64436 18582 RHOG GTPASE CYCLE%REACTOME%R-HSA-9013408.2 RHOG GTPase cycle 13511 12389 22324 22319 11855 277360 192662 263406 11857 14570 68813 19349 18805 624814 70584 56418 56384 70361 233103 22325 229658 544963 622434 66251 68202 16412 545156 16443 13726 23943 75739 57257 140579 628438 71782 17207 94176 330662 94190 16709 52331 218581 84004 21917 56491 26403 109904 224105 238130 18708 230972 20430 56419 70804 380664 104445 56389 13836 59079 223666 108037 69922 223435 98386 330914 232906 56212 71435 228359 66508 208869 22042 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism 23945 75497 16890 19045 12389 64899 14732 21884 14626 14933 67469 215456 14245 19046 103968 66905 64898 13350 12140 16204 16592 14077 233549 67800 18747 14571 68393 14079 19047 14080 75772 11770 18749 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors 12705 12914 328572 332937 17684 80707 56222 21420 21419 226896 64050 21418 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 96%446205 Synthesis of GDP-mannose 110119 69080 331026 15275 29858 54128 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 56489 19697 16150 16151 11350 14672 16412 22601 73699 71978 12675 12306 16410 20846 12334 14083 16416 12336 16402 19052 14682 18033 69543 51792 19246 18035 22330 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5688399.4 Defective ABCA3 causes SMDP3 27410 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 12539 13649 12402 18176 14388 20662 15461 18803 667035 22190 13645 18708 18706 20416 15519 SIGNALING BY ROBO RECEPTORS%REACTOME DATABASE ID RELEASE 96%376176 Signaling by ROBO receptors 13138 622534 14852 238217 214230 17973 16785 16870 666669 16871 100040021 12767 67025 268902 100043391 326622 668182 13176 241053 18186 20779 16876 432502 19087 238276 19989 20663 76808 67252 19899 12331 100043184 241656 19921 71436 19934 18643 100043755 18645 22323 16872 67031 319195 20564 100043209 20562 68193 15399 621100 19941 665189 666899 100042670 100039316 18747 11350 22121 100043876 100043893 100043423 100042986 20115 67281 20662 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 18479 67248 100040331 67941 57294 18481 68092 433702 76707 14733 192160 208643 19056 67923 21762 22123 60365 19179 19181 19182 23996 19184 68134 26440 19166 76499 19167 26441 192170 26442 19826 69077 66997 23997 66441 56436 17149 17463 57296 20422 11848 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70584 70247 12830 224105 19876 259302 223666 20563 14270 117600 19353 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 18749 20102 268721 20103 11352 668668 14853 667739 17974 16825 16392 20315 672214 170822 54003 66481 71745 225058 17925 100038875 18750 18208 100038991 225363 68028 14026 100043000 17690 67891 18458 100043295 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis 20448 15275 50935 192156 67311 225742 236082 107652 26938 20451 19703 245847 227697 20445 20449 54342 19025 50798 54613 66174 57357 50877 56174 14583 13480 14584 234730 13481 22122 241230 75540 228368 66248 24060 240119 218138 20454 109785 52014 12764 20450 57170 69064 94181 74091 68563 67422 20452 18010 241159 23956 235504 110119 69080 331026 29858 54128 20446 20444 20442 20443 20440 12091 20447 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry 15529 11603 23888 20971 20969 15530 14734 50528 70008 18186 171283 103978 269523 71951 18550 20970 14735 14733 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20807 13649 21802 12223 16589 71920 103573 11651 12443 14083 13874 11652 13712 15200 56484 11839 12043 14281 13645 12576 26413 26417 23797 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-HSA-209560.3 NF-kB is activated and signals survival 18053 18412 18033 16179 667035 18035 22190 19697 18049 22034 16150 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209905 Catecholamine biosynthesis 13166 18948 21823 13195 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022870 CS-GAG biosynthesis 77590 12111 121021 13004 78752 59031 60322 269941 58250 29873 74241 13003 338362 71797 234356 53374 78923 12032 13179 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%432720 Lysosome Vesicle Biogenesis 252903 15239 20404 75612 22320 17113 14533 13423 11840 74325 15481 67489 20955 11766 11781 108011 215890 74438 105245 64138 13430 11782 72685 68953 67300 109689 22318 12757 11768 11769 108012 11820 11764 11765 11767 METHYLATION%REACTOME DATABASE ID RELEASE 96%156581 Methylation 22017 67768 108645 13077 57344 67674 238505 11720 232087 210009 14873 269378 18113 12846 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176034.4 Interactions of Tat with host cellular proteins 107951 12455 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 96%3656248 Defective HEXB causes GM2-gangliosidosis 2 15212 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME%R-HSA-392023.4 Adrenaline signalling through Alpha-2 adrenergic receptor 11551 11552 11553 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112399 IRS-mediated signalling 14389 74769 16367 14172 80857 18576 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 327826 18176 14388 20662 15461 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 18607 DEFECTIVE ABCC2 CAUSES DJS%REACTOME%R-HSA-5679001.5 Defective ABCC2 causes DJS 12780 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions 16412 15530 16775 16776 16777 16779 16780 16410 12822 226519 16782 16772 192897 23928 109700 16773 16398 16774 18074 16400 16403 18073 16404 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-HSA-9616222.3 Transcriptional regulation of granulopoiesis 328572 319178 319183 319182 12400 232440 20375 12575 319190 319149 211586 13555 21781 16842 319176 12567 12566 319181 14461 15077 21349 14581 16194 14247 12224 110794 12606 12986 214162 20181 110052 17869 319169 12608 20848 625328 78303 19401 15267 319188 15270 319168 319167 17863 624153 319186 382522 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation 20437 99152 636931 668450 328234 76608 19823 227738 74153 22201 79263 22209 74244 53323 140629 68497 70620 330369 23807 140499 59009 17237 50788 22213 67128 433766 22222 224938 22214 17999 98766 67615 19155 268470 67588 59026 107568 230903 66772 208372 76454 70093 329152 117146 65247 22215 65255 67345 81018 84585 67731 217342 142687 209462 78910 231380 65256 70392 69807 76580 244421 22036 224170 240396 225055 24105 232539 56515 170823 215061 67138 19822 74132 67490 231670 672511 226098 69754 224619 77113 14897 59044 12702 207952 70348 320118 170737 70928 56228 30843 68854 76294 211007 72323 399566 30945 68098 100763 214931 67923 106052 242960 30838 30050 50762 56438 50754 213980 68628 50789 30839 22195 50873 16396 56424 218203 93836 26554 211255 71745 22210 66105 56371 27401 80751 66313 107995 21762 22123 19179 19181 19182 23996 19184 75788 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 67089 103583 70247 117589 78541 69299 218215 94090 233902 69116 208650 73998 50760 20821 235320 242521 209239 74492 75234 66799 72194 67845 15204 69706 235439 57751 140630 94091 217194 16924 22019 226541 65257 104184 19820 78913 242785 56791 68729 69010 211949 66743 233040 231672 18744 50492 224826 231863 101358 12449 224023 109161 83814 22193 71538 76375 67455 14794 100041766 217217 216150 71999 269529 93765 83962 66589 230654 635668 240028 66515 269514 78889 68431 230904 28105 71865 380928 50868 207215 22200 627648 207304 75717 70294 67921 100041484 22192 66663 142688 217232 243574 56317 321006 59008 268291 209200 66156 74646 216080 448987 69957 22346 17222 56736 228003 68612 52563 12703 22194 212919 71393 68999 54484 52206 20439 100039535 218793 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis 12469 12461 14466 12464 30050 50762 24128 50754 12447 216853 12448 15183 108077 27055 71833 14447 213980 68628 22059 12465 16553 55946 50789 20848 30839 12466 67134 21454 12462 20698 99371 106052 66887 242960 12467 30838 12468 DEGRADATION OF CRY AND PER PROTEINS%REACTOME%R-HSA-9932298.1 Degradation of CRY and PER proteins 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 18626 67089 18627 103583 18628 70247 12953 12952 21762 22123 50789 19179 19181 19182 23996 19184 26440 19166 216080 19167 26441 26442 69077 66997 23997 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622327 Postsynaptic nicotinic acetylcholine receptors 11438 110834 11449 110902 11435 11448 11447 11440 108015 108043 11444 110835 231252 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 96%8874081 MET activates PTK2 signaling 16412 16775 16776 20779 16777 16779 16780 17295 15234 226519 14083 16782 16772 23928 16773 16398 16774 16400 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 224912 14609 56217 12695 21872 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190241 FGFR2 ligand binding and activation 14172 80857 14180 14178 14177 67112 64654 14175 14174 14173 14164 14181 72514 80903 14165 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency 14854 SIGNALING BY TCF7L2 MUTANTS%REACTOME%R-HSA-5339700.5 Signaling by TCF7L2 mutants 13017 13016 21416 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013423 RAC3 GTPase cycle 106952 71893 26934 16449 110279 330177 75409 105855 242687 216963 386750 17969 20947 212285 237038 13511 70497 12389 320634 11308 22319 20619 11855 224480 277360 11856 107746 13058 241275 11857 13057 108100 76117 19349 218952 26431 17970 70584 101314 56418 17972 66898 70361 71302 233103 22325 71544 229658 16412 13726 23943 75739 94190 52331 218581 84004 21917 109904 224105 18708 18709 20430 18479 56419 70804 380664 104445 13836 59079 223666 69922 14270 223435 98386 330914 232906 71435 228359 20514 66508 21844 11352 105827 195727 210293 50884 71709 83767 22042 170758 329165 109934 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 96%8949275 RUNX3 Regulates Immune Response and Cell Migration 20750 16401 12400 16408 12399 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death 14103 12532 12380 74568 12333 232440 13626 319149 15077 52615 19646 18969 18968 13436 13435 13433 245688 19075 19076 12261 22059 15267 319168 319167 12370 19766 319186 56532 319178 319183 319182 22030 319190 319176 319181 54722 71609 14082 12578 14056 319169 12334 12336 20656 56484 625328 16476 78303 69543 319188 18477 15270 21672 16906 22627 12569 12568 11820 624153 99412 12125 12530 12531 382522 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants 18595 DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963743 Digestion and absorption 14917 11722 76768 12613 14916 69060 20537 18946 20526 109791 56485 18947 58866 69983 67717 232714 69656 14915 81600 71884 226413 100043686 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling 13866 18803 13649 13645 NEURODEGENERATIVE DISEASES%REACTOME%R-HSA-8863678.3 Neurodegenerative Diseases 14103 12532 12380 12333 12334 12336 20656 56484 16476 69543 18477 21672 16906 22627 12569 12568 11820 99412 12125 12530 12531 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 96%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) 20531 DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME DATABASE ID RELEASE 96%5619081 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) 13162 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 18011 232232 13388 16449 240055 225164 20602 11487 54485 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 15213 56233 17869 15214 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 15205 19664 433759 15182 DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) 18400 PLUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164525.3 Plus-strand DNA synthesis 268373 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis 252903 12487 19353 11771 11772 71770 11840 14360 108664 232910 11773 12504 94176 15162 15007 16818 12526 12010 11768 224105 140580 11769 108012 11764 107975 11765 11767 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%191273 Cholesterol biosynthesis 73166 13595 15490 110196 14137 98386 100040592 235293 68603 20775 192156 13121 20788 13360 14593 16987 319554 17855 20787 74411 74754 66234 18194 110460 68865 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) 17001 BIOFILM FORMATION%REACTOME DATABASE ID RELEASE 96%9931953 Biofilm formation 109637 17075 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 233833 12534 22628 11651 60599 11652 67338 20620 26416 66214 19646 234366 240087 77976 13001 13000 100039026 17988 19094 234594 245688 382985 54401 55948 14751 23942 78757 50493 104625 108099 108083 18607 328572 15257 18983 270627 228980 319944 21374 20922 59035 20833 71361 216185 108143 66464 68776 14776 99730 70439 67655 20869 21399 64930 107951 57314 114741 66508 15258 72504 545987 21343 209361 12914 226182 12454 54170 75747 11909 24074 22084 52187 58202 68576 66096 83409 12857 67923 74370 27224 68441 27632 12450 24116 268706 12455 69131 72949 13716 63856 245670 53621 110323 16476 72068 18477 12861 21672 232791 19650 22627 12569 19651 12568 12862 12868 66142 216848 12532 12866 12865 100041785 208836 107932 12662 72119 18148 53376 19211 333182 68428 216456 66494 100039786 26992 22059 68742 14102 12362 380975 268936 229542 670717 23988 21933 17992 69076 18718 22061 12028 226830 244349 74747 11783 69562 20393 12575 18854 211586 13555 21781 12566 12447 13163 12448 12576 80751 73699 11799 69181 19052 17192 77683 19053 51792 20877 22166 21981 228140 17248 17165 70088 26931 13496 53325 69125 12428 17246 209456 219024 110147 26399 219103 66813 22062 319801 58184 52679 12578 104394 241764 12858 12427 107986 13197 57748 14660 67956 268973 230784 20463 76367 69260 18861 14381 17685 17350 78893 225655 52846 231464 68705 98053 27374 667035 13871 22190 66420 69833 64058 67710 245841 69920 20022 14885 209357 66467 20020 17708 231329 17709 20021 17710 69241 66671 17749 12795 100043714 17420 12572 13872 20924 23894 14884 57913 12366 12368 14281 19360 17535 12053 76850 21975 239528 19364 84682 27354 12021 29813 59092 81601 50883 56187 327762 228829 236511 19352 241113 22427 56717 333654 19718 69263 15574 11920 16009 12189 213988 235610 231724 12227 237911 217351 19355 12122 214150 66262 225182 12142 227743 26909 18538 235559 12144 68275 106344 78783 72151 211651 14088 68240 17454 252870 19891 15469 109270 22631 12177 19367 19356 105787 22629 108079 20878 19079 12649 108961 108097 18996 18997 433759 12905 219022 19082 56716 15182 23797 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 96%110381 Resolution of AP sites via the single-nucleotide replacement pathway 18970 11792 22594 16882 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity 12534 20393 18854 11651 60599 12566 11652 67338 26416 13163 19646 234366 80751 77976 13001 13000 100039026 19094 245688 73699 69181 23942 19052 17192 77683 78757 19053 51792 20877 21981 108099 108083 18607 17248 328572 17165 15257 70088 26931 53325 12428 17246 209456 219024 110147 270627 26399 228980 319944 21374 20833 22062 216185 108143 66464 68776 99730 70439 20869 114741 72504 15258 21343 209361 12578 226182 241764 24074 12427 12450 57748 63856 67956 12569 12568 76367 69260 216848 107932 72119 27374 53376 667035 22190 12795 26992 22059 19360 17535 21975 268936 229542 27354 12021 29813 81601 50883 23988 327762 228829 241113 22427 333654 56717 19718 69263 18718 15574 11920 22061 12189 235610 231724 237911 19355 226830 66262 225182 12142 227743 26909 235559 12144 244349 68275 106344 78783 72151 68240 252870 19891 109270 19367 19356 105787 108079 20878 19079 12649 18996 108097 18997 433759 219022 19082 56716 15182 23797 LEISHMANIA INFECTION%REACTOME%R-HSA-9658195.3 Leishmania infection 17913 13479 58861 246256 17973 14131 17909 66824 330319 216799 76884 12495 19087 19084 22612 22324 217344 20620 93671 16153 17886 26416 12928 26413 229709 26417 14360 16438 16439 18747 22325 11350 16440 12502 57257 17096 11465 22166 15516 15368 18550 16193 640703 26419 16476 18033 18803 50884 83767 329165 71893 105855 11491 242687 19697 237038 11308 14697 241275 13057 108100 11461 14710 14699 66066 14700 101314 14708 14706 12266 14704 14695 14693 140579 64337 14709 16176 330662 12362 14701 15162 56338 140580 20430 14702 16173 14696 19088 234779 69146 17918 19108 12499 18034 12267 76709 73178 19353 104110 22418 20963 16175 14678 14677 12229 56443 14687 19200 14679 432530 210044 14369 104111 80987 68089 14688 67771 11867 54483 56378 18438 66713 74117 13542 70086 224129 245880 11512 11513 11514 11515 14191 18749 13544 14083 13543 22376 215280 14598 18439 319446 68524 67955 13035 11541 23959 17925 23887 17882 14129 242851 19085 INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity 56436 17463 57296 20422 26445 26446 19172 19173 19175 66894 19177 72607 68031 73162 26443 11651 19720 26444 11652 21951 74493 19170 14302 66413 667035 19211 22190 59029 17999 67089 70247 13001 13000 100039026 56424 11798 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 54484 23797 66997 23997 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells 16531 16533 140492 504186 231252 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 17685 68275 17350 17688 18971 68240 18972 19891 67967 16881 69745 26909 18538 18861 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism 94181 20448 74091 20452 18010 241159 23956 50935 235504 67311 225742 26938 20451 20445 20449 19025 50798 54613 50877 241230 20446 20444 24060 20442 240119 20443 20454 20440 12764 20450 12091 20447 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling 328572 20848 60533 13433 433759 16186 12142 15182 15183 15251 20466 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855204 Synthesis of IP3 and IP4 in the cytosol 18796 18797 18795 234779 320634 19211 269437 104015 16330 16331 16332 269615 18798 18799 72469 18802 217837 640703 228550 74055 320404 114875 104759 233011 18803 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 96%9673163 Oleoyl-phe metabolism 212933 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 96%9648025 EML4 and NUDC in mitotic spindle formation 78798 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 59125 59126 12235 217718 67037 68097 16319 19052 73804 19053 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 18817 110379 69928 13427 76499 13426 52504 13424 228421 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%427975 Proton oligopeptide cotransporters 65221 56643 100561 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B 27419 FERTILIZATION%REACTOME%R-HSA-1187000.4 Fertilization 212670 271036 71564 14595 12527 22787 329954 71078 11434 22788 22786 16532 106757 225865 74096 73456 12659 320225 56622 74468 76856 75510 11495 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission 18796 18797 18795 12326 14811 18039 14810 11472 20779 320472 19087 19084 23859 238276 14814 68606 52163 14813 12322 12323 108058 12325 26413 26417 18747 100039592 110651 18176 20112 15461 17920 108099 18607 53623 14799 57014 17246 110304 14680 243547 16559 14802 55984 19417 19418 18693 16519 16520 54393 211323 16518 15561 22343 16516 14402 14401 14400 14399 110886 14800 14397 14396 14395 14394 16521 11438 16522 110834 16524 11449 16513 640703 110902 16515 11435 54377 11448 21912 11447 14409 11440 74053 108015 14408 108043 18195 11444 14407 110835 14406 14812 231252 16517 108030 64011 207565 57249 12300 54376 18752 12361 81905 14658 237213 14654 328699 319924 67071 170483 236915 22342 242425 216963 14697 18751 14710 14699 66066 14700 14708 14706 110637 14704 14807 14806 14695 13385 14805 52589 53310 14693 13383 14809 64337 14709 14701 14702 14696 241113 19088 19108 19353 104110 11771 14678 14677 14679 432530 210044 104111 14688 20111 224129 11512 11513 105787 11514 108079 11515 19079 18749 108097 19082 18750 242851 19085 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development 328572 246086 19213 18508 21410 16334 21405 11925 18088 18096 56458 15376 18012 18609 18128 333639 15379 378435 11651 15377 11652 320995 270118 53626 103988 12914 14534 18519 20526 15205 15874 19664 30942 103806 23797 14165 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 96%209543 p75NTR recruits signalling complexes 18759 192656 18053 17874 18412 16179 667035 22190 18049 22034 16150 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade 14685 20215 12788 214111 212541 225600 14699 18587 18588 14688 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%975871 MyD88 cascade initiated on plasma membrane 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 71481 667035 26416 211550 22190 17258 20203 26410 26409 20210 24110 26413 103583 257632 26417 26940 266632 26401 80750 223664 53791 107607 19094 69721 102626 231130 93834 270151 73699 11596 26395 67454 22059 240518 71966 110651 108960 20112 59025 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 12370 21770 22030 67245 26399 26400 18034 26398 26420 13712 26414 26397 17260 434174 66513 93765 66589 23939 22034 66724 68652 20111 11909 26419 12675 16476 18033 18035 18036 11820 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 328572 12914 20181 56406 19013 21372 109151 19883 17977 19017 17978 59035 81004 66993 12894 20787 268903 19014 19885 229003 15183 20185 217166 SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 96%9669933 Signaling by kinase domain mutants of KIT 16590 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis 319178 319183 319182 232440 13626 319190 319149 319176 319181 15077 54722 52615 19646 18969 18968 14056 13436 13435 245688 13433 19075 19076 319169 625328 15267 78303 319188 319168 15270 319167 624153 319186 382522 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME%R-HSA-6802952.3 Signaling by BRAF and RAF1 fusions 74244 20779 12322 12323 109880 108058 12325 26413 26417 12988 109905 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 11836 26372 109689 56463 216869 26936 21848 11774 330286 16452 67726 110135 100986 99571 78781 22330 19317 16706 11610 76156 210106 66549 16905 67095 14359 69923 338523 640703 17169 23971 12125 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium 20873 68121 76260 81896 12534 69940 78887 16570 71769 107338 21821 22628 76411 277939 225745 241950 231123 66482 654470 67590 74360 73242 238799 18536 109181 13196 68259 66296 214552 59030 74201 18541 76568 75786 66061 15519 16568 18747 213081 213575 67161 19889 53869 71909 140810 237222 52028 67378 93730 102774 74025 17997 12879 68097 67978 264134 18005 215445 73738 68475 51792 53598 208518 67694 380718 100041639 67286 236266 20607 78802 106633 244585 12009 99100 103733 319845 22154 74470 104318 56455 101565 110350 16559 16328 219103 18763 18764 260305 76779 16579 83922 71492 245866 216363 26370 76707 13589 18472 232987 21454 12462 13427 22627 13424 27373 12469 12461 12464 64436 18582 227613 68146 22153 22142 212541 22145 12465 100986 319757 12589 19088 56350 77048 230376 69654 52906 17274 18000 73668 67661 75296 53413 75465 15185 72421 72140 106840 67344 67068 219072 11843 20336 56297 225659 107371 72938 53885 207911 76478 320299 329795 78177 16569 217935 27078 28135 214444 76816 74019 217335 54130 105504 74682 211446 72569 18817 71820 381644 102058 109242 67042 233649 73916 12789 382090 232944 231214 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 96%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 21374 67065 71752 74414 233863 66420 72308 69833 66596 78929 245841 544971 70239 269252 26939 67486 70408 20018 69870 70428 67371 17749 218832 100043714 67005 20016 98488 12909 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 96%8941284 RUNX2 regulates chondrocyte maturation 16147 12400 208727 14633 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 96%6811440 Retrograde transport at the Trans-Golgi-Network 17957 67542 78689 242406 56382 53330 228960 69834 224705 76899 245944 97484 68505 233824 54214 232286 68299 22319 227746 70297 66905 17113 76932 18195 73296 108123 108124 16004 74375 76332 16834 226089 76688 270192 53611 56367 319642 102339 19346 98910 58244 70646 78304 338337 104303 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins 214254 53893 66358 75686 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73776 RNA Polymerase II Promoter Escape 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6782315 tRNA modification in the nucleus and cytosol 107508 108943 328162 233189 240174 76357 74455 229780 66965 209584 68736 30947 13434 100929 54632 68260 73681 68916 66966 28114 66369 67049 57773 17299 100043886 66757 67674 106248 68205 66628 66246 212528 69786 329504 60507 67667 78890 319582 78697 76367 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 96%430116 GP1b-IX-V activation signalling 110157 14723 22631 18708 14724 192176 54368 14729 22371 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 96%430039 mRNA decay by 5' to 3' exoribonuclease 67678 234699 24127 66094 13209 319618 67207 70640 75901 78651 27756 353190 225929 66373 50783 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane 12469 76260 12461 69940 12464 71769 107338 241950 64436 18582 66482 68146 73242 13196 212541 59030 19889 53869 52028 67378 93730 12465 102774 74025 12879 215445 20607 319757 319845 56350 18763 18764 17274 71492 216363 53413 15185 106840 11843 20336 56297 107371 207911 105504 211446 72569 21454 12462 102058 233649 12789 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 96%174113 SCF-beta-TrCP mediated degradation of Emi1 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 26443 67141 26444 107995 19170 66413 26965 56371 667035 22190 59029 67089 70247 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME DATABASE ID RELEASE 96%9702518 STAT5 activation downstream of FLT3 ITD mutants 14389 20850 18712 50490 14784 12575 12048 14255 19247 20851 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 71519 106648 100040843 13078 72303 107141 13077 13076 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression 22632 233833 232440 319149 16478 12443 15077 12005 15519 100039592 17869 21802 20842 24061 19014 15516 19357 328572 12400 17977 14462 21374 17978 59035 268903 107951 13006 12914 235459 11909 83602 12455 16476 12043 17863 20843 20683 14732 68705 98053 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 13982 17749 100043714 15267 319168 18667 319167 14281 76850 239528 319186 319178 12705 319183 319182 81601 236511 319190 14282 319176 319181 213988 217351 214150 67393 12648 13033 99982 14228 18986 17979 193796 228913 13207 21887 15375 55960 268527 107351 17454 26424 21786 15469 319169 22282 22278 18519 100041004 100043508 625328 78303 319188 15270 433759 20315 624153 71393 382522 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373760 L1CAM interactions 235281 56613 74947 20266 20265 13004 12805 11733 11735 14432 640524 18186 20742 20741 319504 73086 20743 20404 26394 20271 399548 20272 20274 20273 109700 103967 16398 11658 110876 53321 20269 72821 110880 22350 17967 26413 269116 26417 71653 80297 20264 22325 213119 13001 56705 13000 100039026 16412 13649 13385 53310 26395 13383 26396 16777 110651 20112 16399 226519 16416 16402 16772 18479 19353 53378 11771 11772 71770 15481 20111 232910 11773 13430 18222 16571 16410 21367 53870 24046 13844 16728 12661 18187 67300 13429 13193 12757 19684 12934 16536 17698 110862 67071 104099 20739 20740 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 96%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 20492 72290 116748 20638 384091 666609 243963 68092 67332 433702 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation 233833 232440 319149 211586 18129 13555 18131 18128 21781 18132 12443 270118 18759 15077 13557 50721 13710 22059 15267 319168 319167 76850 103806 239528 319186 328572 319178 319183 319182 236511 319190 333639 319176 50701 319181 213988 217351 214150 12914 17454 14534 319169 18519 625328 19664 16476 78303 319188 15270 624153 382522 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-HSA-5654687.4 Downstream signaling of activated FGFR1 327826 80857 14180 399558 396184 14177 67112 64654 14175 18176 14174 14388 20662 14173 14164 15461 71436 107971 18803 18708 19247 14165 18706 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702506 Drug resistance of FLT3 mutants 14255 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA 97212 11363 231086 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation 216848 328572 70088 23988 18854 219024 26399 107932 18718 11651 11652 66262 19646 234366 244349 78783 245688 26992 22059 23942 17192 433759 15182 268936 229542 23797 69260 108083 SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM 20020 231329 20021 69241 17749 100043714 68092 14183 14173 433702 14164 68705 98053 66420 69833 67710 245841 69920 20022 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112315 Transmission across Chemical Synapses 18796 18797 18795 17161 12326 14811 18039 14810 11472 20779 320472 23859 19084 14814 68606 52163 14813 26413 26417 18176 15461 17920 108099 18607 14800 11438 110834 11449 110902 640703 11435 11448 11447 11440 108015 108043 11444 110835 231252 22318 20614 20979 20907 216963 63993 14697 14710 14699 66066 14700 216456 14708 14706 110637 14704 14807 14806 14695 13385 14805 52589 53310 14693 13383 14809 13162 64337 14709 14701 14702 14696 19088 19108 11771 104110 14678 14677 14679 432530 210044 104111 14688 224129 11512 11513 11514 11515 18749 14415 14417 242851 19085 19087 238276 12322 12323 108058 12325 18747 100039592 110651 20112 12038 268860 12647 11423 67111 22348 214579 27204 19339 13002 20965 20964 68507 327814 12889 22249 791260 15567 12286 12287 12290 53623 232333 14799 14412 57014 56808 17246 110304 12293 14680 12295 243547 12296 16559 12297 14802 12298 55984 243616 19417 233977 19418 14645 18693 214084 16519 20508 16520 65106 54393 20518 211323 20517 16518 12294 15561 22343 16516 14402 14401 14400 14399 110886 14397 14396 15481 14395 14394 16521 16522 16524 16513 16515 54377 21912 14409 74053 14408 18195 14407 14406 14812 16517 108030 64011 207565 14660 57249 12300 54376 18752 12361 12846 81905 14658 237213 14654 328699 319924 67071 170483 236915 22342 242425 18751 241113 242607 14411 67760 19353 20513 11669 20511 20510 20512 20111 105727 105787 108079 19079 108097 19082 18750 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) 22632 56438 70620 11545 667035 13871 16881 22190 11461 14885 209357 66467 56469 66671 17420 12572 13872 20610 23894 14884 22196 100043429 12848 229615 27015 69745 100043806 26891 59001 22594 26754 16882 19687 19718 56456 69263 66979 26370 77593 56505 68058 225280 26893 56249 93765 69714 93836 227195 18538 109275 26894 68142 11546 13870 68275 108679 106344 233875 72151 70020 18971 19358 68240 19359 18972 235134 22590 19891 22591 107986 18973 26572 18974 22592 50505 26895 67967 99375 72584 13194 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 96%73929 Base-Excision Repair, AP Site Formation 319178 319183 319182 232440 319190 57321 319176 319181 17193 234258 71726 319152 382913 18294 21749 72774 497652 18207 21750 319169 268395 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism 69772 208982 110446 15360 78894 71911 15356 67041 64059 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%5662702 Melanin biosynthesis 13190 22293 18431 22173 22178 DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication 52717 99152 668450 232440 319149 12566 15077 12447 56371 27401 16881 12448 12545 16211 12428 109145 17216 272551 17215 17217 17218 17219 17220 78833 12544 69270 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 226153 69077 19819 66997 50776 23997 18975 216151 56436 27214 17463 67177 57296 23834 74528 20422 208194 26445 14156 26446 57441 19172 70024 19173 381760 19175 16650 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18969 18968 19075 19076 15267 319168 319167 69745 21975 319186 319178 319183 319182 327762 59001 319190 16646 19687 19718 319176 69263 319181 66979 50793 18392 18393 66634 26428 26429 56452 18538 68275 106344 72151 18971 68240 18972 19891 18973 319169 18974 67967 217232 56317 625328 59008 78303 319188 66156 15270 216080 69957 17222 75430 68612 52563 624153 22194 68999 52206 100039535 382522 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants 16590 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 16785 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 100039316 20115 76846 100040298 13665 67204 267019 26905 67941 57294 75705 27207 67097 13685 670832 13684 633683 20044 27050 208643 667279 20085 668144 20084 382492 20055 75617 27370 629957 20102 20103 668668 667739 66481 225058 100038875 18458 GSD 0%REACTOME%R-HSA-3858516.4 GSD 0 232493 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654693 FRS-mediated FGFR1 signaling 327826 80857 14180 14177 67112 64654 14175 18176 14174 20662 14173 14164 15461 107971 19247 14165 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 70620 12566 16881 240087 11350 50721 19822 12428 319152 13870 12427 50505 20422 667035 22190 107823 68251 20184 66131 269582 232314 70681 70238 27223 19365 56420 107976 210766 21853 59004 22196 100043429 15204 52864 19360 27015 69745 17535 21975 19363 319186 19364 27354 319178 12021 319183 224008 319182 60530 81601 327762 269400 59001 319190 19361 114714 209334 22427 19687 19718 69263 15574 11920 319181 66979 12189 12190 235610 231724 237911 19355 57434 225182 74335 93765 26909 18538 235559 71711 12144 381306 68275 106344 72151 18971 68240 18972 233826 19891 18973 18974 80905 19367 19356 19362 67967 268465 12649 78303 319188 15270 382522 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 96%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 328572 21372 109151 17977 19017 18143 17978 59035 81004 66993 17260 17261 12753 268903 19885 70461 15183 20185 225998 93759 217166 74343 12914 20181 382056 56406 19013 11909 19883 19014 229003 11865 19377 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events 18796 18797 18795 12326 19088 14675 55984 19108 19087 19084 104110 12322 12323 108058 12325 432530 210044 26413 104111 229709 16438 16439 18798 18747 14672 100039592 640703 224129 14676 16440 18753 11512 18783 11513 110355 11514 18575 11515 18574 18573 18749 207565 14682 18752 18750 19085 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines 232440 319149 67155 239985 20586 20588 20587 319176 12567 56456 12443 15077 59035 66993 99890 140858 27374 70465 83766 667279 13435 93760 245688 66923 15469 319169 71974 621893 68094 214572 83796 319162 83797 15267 319173 57376 319163 319168 66423 15270 319167 624153 16452 77044 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 96%9665244 Resistance of ERBB2 KD mutants to sapitinib 13866 59079 12539 15519 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.4 Signaling by TGF-beta Receptor Complex in Cancer 21803 21812 21813 17126 14225 17127 17128 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 96%1679131 Trafficking and processing of endosomal TLR 13038 170743 13039 13040 19141 170744 13030 22027 54445 142980 81897 INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166663 Initial triggering of complement 317677 14134 14962 12263 17195 12266 12944 625018 11537 16904 12259 71693 12260 12262 667277 239447 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-HSA-74751.5 Insulin receptor signalling cascade 14389 74769 16367 14172 80857 18576 16334 14170 225326 14180 14178 14177 14783 67112 16337 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 26413 26417 20416 327826 18176 14388 20662 15461 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 18607 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 96%9665249 Resistance of ERBB2 KD mutants to afatinib 13866 59079 12539 15519 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-HSA-1834949.6 Cytosolic sensors of pathogen-associated DNA 56480 12387 446099 54131 207521 58203 19697 16150 16151 17874 667035 22190 66420 69833 245841 69721 17749 100043714 20821 71966 69807 17535 142980 19766 56532 328572 106759 19090 384309 18034 22040 383619 72162 72935 72512 54123 67065 20852 268857 74414 22596 13211 14375 214763 78929 26939 67486 70408 12914 20018 69870 70428 218832 67005 20016 12909 12675 18033 18035 18036 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME%R-HSA-9909615.2 Regulation of PD-L1(CD274) Post-translational modification 12234 56436 17463 16451 57296 20422 26445 13200 26446 19172 19173 72297 19175 22628 19177 21402 56438 12567 26443 12443 26444 19170 269523 66413 26965 667035 22190 18566 59029 67089 70247 13001 13000 100039026 20747 244373 18005 60533 76580 108099 226144 66357 193670 54197 26754 241113 70377 216440 20014 103963 56637 69038 13135 66753 67819 26554 116891 20338 21762 67075 22123 105787 108079 19179 19079 19181 19182 108097 23996 19184 26440 19166 58205 19167 19082 80286 26441 26442 68292 69077 66997 16430 23997 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 96%204005 COPII-mediated vesicle transport 17957 193813 12068 317717 56494 60409 89867 235416 216131 66397 67231 66890 69608 218811 99683 56418 70361 77371 20334 21802 12836 56389 14799 104318 67091 20703 66226 19324 105522 243819 14067 69162 14275 12793 67857 100042773 20333 215474 64138 207352 74498 66682 18195 52036 108123 76983 108124 13032 245828 12794 240667 67727 214895 59005 14069 110379 78232 56041 11839 333883 21787 27096 72978 227648 99412 76308 76510 100042343 50907 MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702600 midostaurin-resistant FLT3 mutants 14255 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9940951 Interaction of NuRD complexes with transcription factors 216848 14377 232440 319149 13445 269610 106795 107932 22780 22779 78266 228880 15077 52004 17191 233410 11819 22778 622675 70998 14121 19646 234366 245688 23942 17192 15267 319168 319167 229542 319186 319178 319183 319182 319190 319176 319181 116871 22026 116870 319169 625328 78303 319188 15270 433759 15182 624153 18534 382522 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 96%5579030 Defective CYP19A1 causes AEXS 13075 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis 23945 22065 22068 18754 18755 320127 18761 76192 104418 16438 19395 56077 16439 66082 231871 380921 110524 269060 110197 217480 13139 331374 26946 19419 16440 18753 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 18747 640703 12326 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5658623 FGFRL1 modulation of FGFR1 signaling 14172 116701 114715 67112 114716 64654 14175 14174 14165 14173 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 96%444821 Relaxin receptors 23919 140498 212108 19773 242093 381489 239336 16336 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%9675136 Diseases of DNA Double-Strand Break Repair 12021 81601 327762 20422 19361 114714 22427 19718 69263 15574 11920 12189 12190 235610 231724 237911 19355 57434 225182 26909 235559 12144 68275 106344 72151 68240 233826 19891 19367 19356 19362 19360 17535 21975 19363 19364 27354 RHOB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013026 RHOB GTPase cycle 26934 110279 21873 12389 22319 20619 11855 277360 14570 71302 22325 229658 19877 17207 52666 16800 94190 263803 52428 14251 13605 218581 270163 84004 20166 236920 19878 13830 109904 16480 18708 68743 18709 20874 213498 56419 12704 243362 110596 207212 19285 14252 59079 71704 223666 234094 11464 330914 50768 232906 56349 54216 71435 16801 228359 11852 404710 13367 75547 20868 268301 320795 109333 72754 208846 69632 17925 22042 109934 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 96%428540 Activation of RAC1 19876 214230 17973 20563 18481 20663 20662 19353 241656 17974 224105 70584 18479 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events 11848 102098 20663 22324 14697 277360 14710 14699 66066 14700 22325 14708 14706 622434 14704 545156 14695 16443 14693 57257 64337 19877 20662 14709 17207 16800 14701 13605 19878 109904 230972 213498 207212 14702 71704 234094 223435 14696 56349 16801 11852 19418 75547 72754 69632 12229 213649 24001 224014 230098 53972 30938 21390 77669 442801 226970 235611 14688 54126 101497 14673 269608 328967 14163 26382 268739 14674 73341 11550 11853 11548 11549 21844 236915 109934 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids 11666 26458 15488 113868 170789 26378 74147 171282 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease 74769 107351 268980 18595 18176 20846 54214 20662 20848 15461 16542 66899 14011 668218 18708 18709 18706 67561 S PHASE%REACTOME DATABASE ID RELEASE 96%69242 S Phase 52717 99152 668450 17187 12575 211586 13555 19645 21781 12567 12443 11651 12566 11652 12447 56371 27401 16881 12448 12576 19646 17869 218914 20842 24061 19357 12428 109145 17216 272551 17215 17217 100710 17218 17219 17220 78833 12544 69270 67849 13006 13559 104394 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 71521 26441 19651 63955 22390 26442 72568 69077 77805 20843 66997 12530 231506 23997 12531 629959 54124 56436 20459 17463 67177 75660 57296 23834 71988 20422 26445 14156 26446 57441 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18969 18968 66671 19075 19076 17420 12572 69745 327762 59001 19687 19718 69263 66979 50793 18392 18393 66634 26428 56637 26429 56452 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 67967 217232 56317 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 23797 52206 100039535 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375280 Amine ligand-binding receptors 11554 11555 11556 15560 15559 15558 213788 15557 13492 382348 13491 13490 13489 13488 111174 215855 503558 215854 12672 12671 15552 15466 15551 15550 243764 12669 15465 99296 18241 209512 15566 15565 15563 15562 225192 11550 11548 11549 11551 11552 11553 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%5693532 DNA Double-Strand Break Repair 70620 12566 11545 16881 240087 11350 100039592 50721 19822 12428 319152 11546 13870 26419 12427 50505 20422 14156 667035 22190 107823 68251 20184 66131 269582 232314 70681 70238 27223 19365 56420 107976 210766 19060 21853 55982 104416 22059 51869 59004 56626 225896 14051 56196 22196 108138 100043429 93762 22385 11785 75570 15204 104884 319583 230674 52864 227525 19360 54125 27015 14050 69745 14049 17535 14048 21975 77782 19363 319186 19364 27354 319178 12021 319183 224008 319182 60530 81601 50883 327762 269400 59001 319190 19361 22594 114714 16882 209334 22427 19687 19090 19718 69263 15574 11920 319181 66979 12189 12190 235610 231724 237911 22596 19355 57434 14375 225182 74335 93765 26909 18538 235559 71711 12144 193796 381306 68275 106344 72151 18971 68240 18972 233826 19891 18973 18974 80905 19367 19356 19362 67967 268465 12649 78303 319188 15270 382522 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9759475 Regulation of CDH11 Expression and Function 12385 233833 59058 110751 12564 15426 24136 12388 16201 12387 236511 20613 20683 12552 57875 15227 213988 217351 214150 17454 56198 16480 76850 77630 239528 11492 239096 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME%R-HSA-4341670.3 Defective NEU1 causes sialidosis 18010 19025 12091 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 328572 18011 13388 16449 240055 225164 11487 54485 16450 18514 218977 18131 67784 66894 18128 333639 19208 211652 21335 270118 667035 22190 12140 22608 12914 15213 14534 15214 13649 18519 15205 20846 19164 19165 15208 100042305 208117 19664 59287 100039623 56198 76580 13645 103806 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS 216848 11931 16451 58861 17973 11932 56480 11933 58194 58203 56188 56438 107932 22324 18566 16194 19646 234366 15519 11928 98660 232975 19712 245688 57780 16412 100042069 59095 23917 14815 108017 19877 20662 23942 16401 17192 170743 19878 16452 15516 229542 19766 22154 234779 70008 16453 16177 54721 11771 20963 50724 11772 57261 60406 18550 13609 71770 12229 20847 15980 17060 15979 18024 58799 12518 99982 217864 14228 15985 116871 15975 94246 18391 116870 100041953 110606 26554 71954 107392 14272 238247 232910 15353 50868 11773 100043508 14225 433759 12846 15182 81897 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs 68219 98985 228410 54451 68092 108062 67337 54196 83410 18789 433702 51786 94230 74320 68188 54188 66899 269061 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662361.2 Sensory processing of sound by outer hair cells of the cochlea 13823 17913 227357 192140 13409 238021 628870 332309 18419 97031 80979 20742 17524 56506 102502 224796 72088 98845 328789 56226 60613 16531 433899 16533 13860 17886 140492 329421 504186 227753 22350 19230 231252 241431 73750 12361 140476 16470 17910 19684 23999 22295 17921 17698 667663 381375 193385 20776 20740 11994 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS 20389 IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME%R-HSA-9709275.2 Impaired BRCA2 translocation to the nucleus 12190 20422 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR 15200 11839 13649 21802 13645 12223 71920 13874 POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764790 Positive Regulation of CDH1 Gene Transcription 16600 24136 93760 20683 20901 60611 15376 19645 16601 114142 21418 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 80857 14180 14177 64654 14182 14175 14173 14164 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters 20495 20497 20496 107723 57138 20498 20499 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 96%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 18295 16545 14264 14595 116847 17022 27047 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage 15452 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 193740 667035 22190 59029 67089 15481 70247 208643 15507 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 18458 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors 12843 12842 14325 20288 117158 140792 71693 11806 71145 17167 12827 12317 12826 238055 12825 11816 14319 22027 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol 22084 12575 17246 12015 12371 12675 67605 11651 11652 606496 56637 12576 23797 54484 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME%R-HSA-9699150.3 Defective DNA double strand break response due to BARD1 loss of function 12021 12189 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 96%159424 Conjugation of carboxylic acids 435528 107146 233799 233801 272428 117147 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013409 RHOJ GTPase cycle 216963 66894 12389 320634 68146 22319 20619 11855 277360 19349 26431 70584 68428 71302 229658 75739 217866 105782 94190 14269 22379 218581 80837 214459 21917 14467 66871 13830 224105 226751 16480 18708 76088 18709 218756 18479 56419 104445 223435 330914 232906 18481 71435 228359 404710 73178 20514 66508 54126 14609 22376 68524 71709 22042 SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 20733 20732 15451 15235 19882 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME%R-HSA-9833576.1 CDH11 homotypic and heterotypic interactions 12385 12564 12388 12387 12552 16480 239096 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%1614635 Sulfur amino acid metabolism 64918 246277 66902 14261 12583 12411 67870 211389 12116 67873 14719 14718 66071 73748 107869 56369 104923 27376 246221 211488 22117 56551 59010 226654 238505 11720 210009 269378 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 105083 24015 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins 22209 70620 140499 269523 12042 66105 667035 22190 109331 15007 22195 319186 319178 319183 319182 319190 19090 319181 100041766 93765 68366 18538 20585 76246 108089 214498 225131 67819 56273 66317 668173 103737 72129 19302 235497 66510 22083 268281 68441 109815 233900 320311 54624 78303 319188 216080 22210 22194 58186 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 96%168138 Toll Like Receptor 9 (TLR9) Cascade 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 100561 11909 26419 12675 216238 71398 27056 78287 16476 18033 18035 18036 11820 75669 81897 12234 225326 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 170743 14281 12370 22030 12475 67245 225471 106759 18034 54123 434174 66513 93765 66589 22034 66724 68652 20111 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9918485 Dengue Virus Attachment and Entry 12737 16785 74153 22201 15530 12475 74244 171283 170786 103978 11771 11772 18550 71770 14733 15529 11603 23888 20971 232910 11773 20969 22200 14734 66663 231380 71951 17069 20970 68032 17289 14828 19128 276891 14735 217303 18708 22174 14456 26362 17533 100732 52898 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 96%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 67103 13479 16993 320997 17001 13120 11690 631304 11687 13118 72054 17250 208285 17164 14598 106648 319446 100040843 23887 11689 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167243.5 Tat-mediated HIV elongation arrest and recovery 20922 20833 68705 98053 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 20020 231329 20021 69241 17749 100043714 58202 67923 27224 27632 20924 24116 12455 13716 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway 17309 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME%R-HSA-9824585.3 Regulation of MITF-M-dependent genes involved in pigmentation 20665 12387 67155 239985 20586 17918 20588 16842 20587 245049 70127 56456 16364 11652 29861 269397 20431 19708 268996 66993 11891 171531 26416 12055 12054 11461 77836 77045 83671 21418 18241 93760 22278 68094 83796 83797 57376 13190 22173 22178 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 96%983712 Ion channel transport 11931 14226 11932 20393 11933 11937 11938 65973 53313 56188 76757 109552 67972 11941 320707 381290 12322 12323 108058 12325 20192 20191 20190 107568 11928 98660 232975 57780 59095 108017 110157 13830 72621 242341 68775 76252 11972 108664 66290 640703 11964 110935 11966 100039636 66335 11973 11974 74915 338375 21871 73834 114143 66237 11975 54411 27060 140494 66144 225997 22063 193034 22065 22067 667035 22066 22190 28240 22068 63873 171382 69847 171166 75607 56407 279561 68667 208169 277328 11944 64177 11945 17364 382427 246788 27219 68279 69047 94178 11981 22368 11977 226025 101772 194352 117160 26946 170759 56843 170755 58800 11979 14628 54670 241118 11419 74772 50771 212989 319767 102566 404545 229277 338370 26372 224079 140475 50770 105722 382014 231287 14605 268878 11980 20278 78339 67331 235574 217843 320091 66388 252972 20276 20277 232341 56365 76295 233246 26373 12728 12727 83814 12725 12724 97086 12723 243634 23844 192113 74446 50769 24115 58170 99663 233979 320940 229933 54667 11982 12733 105355 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-3232118.9 SUMOylation of transcription factors 17342 27223 56469 20687 15248 17246 26927 21420 22059 21419 59004 20610 22196 100043429 229615 12578 116870 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 18148 110109 15510 17865 21418 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function 12021 81601 327762 20422 233826 19361 114714 22427 19362 11920 12189 12190 237911 57434 19360 225182 26909 17535 21975 19363 19364 12144 27354 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination 622534 238217 14852 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 235606 67186 382492 20055 75617 67768 27370 65019 629957 67674 20102 20103 668668 667739 14853 672214 66481 225058 100038875 100038991 68028 225363 100043000 67891 100043295 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat 68092 433702 20922 20833 68705 98053 13871 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 14885 209357 66467 20020 231329 12454 20021 69241 66671 17749 100043714 58202 17420 67923 12572 27224 13872 27632 20924 24116 23894 12455 14884 72949 13716 LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5632681 Ligand-receptor interactions 16147 19206 14451 57810 15245 117606 20423 13363 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69109 Leading Strand Synthesis 18969 106344 18968 72151 18971 18972 19075 19076 19687 19718 69263 67967 69745 18538 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 96%1483166 Synthesis of PA 114874 28169 68262 66659 18806 55979 225010 18778 14732 215456 18805 14571 76768 18783 67512 14712 18779 239759 26971 333433 108958 99010 210992 14555 26970 26565 215708 102247 18784 18782 78390 66350 231510 52123 ASSEMBLY OF THE HIV VIRION%REACTOME%R-HSA-175474.3 Assembly Of The HIV Virion 73711 22088 67123 330192 268373 66914 18108 18550 667035 22190 107305 72543 194309 52348 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility 13866 11848 13649 18183 83961 100042150 12223 13367 76890 13874 15200 211323 13645 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) 64176 22317 64051 22318 75209 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity 72674 108097 108099 20869 58805 108079 68465 11450 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression 233833 20665 21415 18992 12387 12575 12550 67155 20586 20588 16842 20587 17295 12443 12566 11652 12047 21385 69675 19303 12558 13612 26416 16881 11886 21417 232313 21752 329581 18787 21418 21414 21416 17216 239985 17218 13367 19017 56456 66993 11972 93759 108664 66290 12578 11964 93760 11966 100039636 66335 11973 11974 114143 12043 13190 22173 22178 12531 20674 192119 245049 70127 16364 29861 269397 20431 19708 268996 16398 11891 171531 12055 12054 11461 77836 77045 83671 17364 18241 68094 83796 83797 57376 76850 239528 236511 17918 12189 213988 217351 214150 17454 22278 66355 15254 20466 18817 433759 68292 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602571 TRAF3 deficiency - HSE 22031 106759 142980 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 18011 232232 13388 16449 240055 225164 20602 11487 54485 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 15213 56233 17869 15214 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 15205 19664 433759 15182 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis 66420 69833 67710 245841 69920 74068 20022 210510 74691 15519 57746 20020 98558 231329 83456 20021 330890 69241 72634 71981 17749 13206 100043714 17864 66715 94244 57749 83561 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112412 SOS-mediated signalling 15461 16367 384783 18176 20662 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876493 InlA-mediated entry of Listeria monocytogenes into host cells 104836 12388 12387 667035 12550 22190 20779 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin 52717 56436 99152 17463 668450 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 30939 107995 21762 22123 19179 19181 19182 217232 23996 56317 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9613829 Chaperone Mediated Autophagy 15129 21821 12638 19752 14580 11520 68146 26369 16784 57320 15185 667035 22190 66905 18541 15516 15481 15519 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 96%5661231 Metallothioneins bind metals 17752 17748 17750 17751 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair 234258 18294 72774 18207 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters 21415 17869 12387 21414 12006 21416 12399 16842 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle 12767 18108 16881 107305 72543 194309 52348 116733 73711 22088 67123 330192 76959 66201 19386 20479 66914 12504 19384 100088 12774 19385 18107 445007 270627 68092 228980 319944 21374 103573 433702 20922 20833 216185 108143 18550 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 69912 21343 209361 226182 12454 229906 103468 235459 24074 268373 83602 58202 68153 74197 67923 234865 27224 27632 24116 12455 72949 59015 13716 69736 63856 110379 14156 68705 98053 667035 13871 22190 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 66371 14884 108138 68953 75608 18571 319583 170762 108989 231042 227699 208092 223921 227720 66700 269113 66679 18141 23825 107939 69482 71805 54563 16646 19069 15361 70699 101739 72787 18226 218210 83814 105513 22596 14375 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) 63993 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME DATABASE ID RELEASE 96%9820962 Assembly and release of respiratory syncytial virus (RSV) virions 15516 15519 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 96%210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 105727 20511 14645 20512 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA 72544 50911 69639 72662 19094 66446 227715 74108 70640 22631 11651 26416 66362 109075 66583 27998 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 96%418889 Ligand-independent caspase activation via DCC 12367 72993 13144 13176 69635 13143 107449 12371 94275 107448 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 66310 140858 213464 23808 381022 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation 17248 26931 12534 50883 20393 228829 12428 17246 56717 11651 11652 67338 11920 12566 53376 667035 22190 13163 227743 80751 12578 252870 12427 73699 109270 22059 12450 19052 78757 19053 51792 56716 23797 18607 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate 21351 21881 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 96%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 15529 11603 23888 20971 14043 14042 20969 15530 14734 103978 71951 20970 14735 14733 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 96%68877 Mitotic Prometaphase 20873 68121 12534 78887 78798 22628 225745 231123 74360 18536 66296 214552 108911 73470 18541 16563 75786 15519 70454 18747 216965 13001 71876 13000 234663 100039026 19047 66977 320394 71909 19386 102920 237222 73699 11799 52276 59125 218914 59126 12235 217718 67037 17997 20842 68097 16319 18005 19052 73804 73738 19053 68475 51792 53598 20877 208518 381318 24061 52696 26886 66934 236266 18221 445007 19357 226849 225849 12009 72155 99100 26931 103733 21770 26932 22154 70385 74470 57294 104318 56455 101565 226747 17120 16328 219103 26951 100710 108000 229841 259279 12237 103573 14211 12617 83922 171567 107995 51885 72415 68298 83815 215387 12615 26370 76789 66570 72083 244495 70099 208628 101706 76707 233276 67139 103768 68014 74237 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 12442 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 22627 71521 13426 52504 13424 228421 20843 27373 227613 22153 22142 22145 100986 19088 230376 69654 75296 219072 225659 381306 76478 78177 28135 214444 76816 54130 18817 381644 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 96%5668599 RHO GTPases Activate NADPH Oxidases 71893 23988 18762 19094 225326 18753 17969 237038 19353 224480 13058 241275 26416 13057 18751 18750 17970 19354 75669 26413 20201 17972 26417 20202 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 96%3248023 Regulation by TREX1 22040 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA 15107 20216 11409 93747 CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) 319178 319183 319182 232440 319190 319149 319176 319181 15077 75605 216850 75467 194388 18140 214899 74319 11628 22289 319169 625328 15267 78303 319188 319168 15270 319167 624153 319186 382522 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.1 Defective FV causes thrombophilia 14067 19128 19123 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation 70408 20018 69870 70428 17749 218832 100043714 67005 20016 12909 67065 74414 66420 69833 78929 245841 26939 67486 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 96%933541 TRAF6 mediated IRF7 activation 328572 12914 56480 22030 15977 54131 56489 71586 230073 66641 21353 71956 228607 217069 54123 22034 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 96%9772573 Late SARS-CoV-2 Infection Events 93687 71164 53618 20448 227619 19089 13200 208884 667035 12330 22190 101772 22196 102566 404545 105722 382014 66357 320091 50528 70008 233246 20014 18550 103963 243634 56637 69038 13135 15469 103534 67075 57377 27801 228136 75965 70546 20817 14423 108687 20815 214424 269181 328417 57437 606496 217664 67287 69035 80285 107895 52552 20446 671535 20444 547253 20442 80286 20443 17308 17158 68292 20440 67569 16430 14376 20447 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 96%4719377 Defective DPM2 causes CDG-1u 13481 68563 13480 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 96%937041 IKK complex recruitment mediated by RIP1 56532 17087 12475 225471 11796 106759 12675 16150 16151 66105 667035 100041766 216080 21898 22190 93765 66589 22034 19766 11797 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9820960 Respiratory syncytial virus (RSV) attachment and entry 15529 11603 23888 20971 17087 20969 15530 12475 13649 14734 103978 16001 71951 13051 18550 20970 19345 271457 19344 21898 14735 14733 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 96%110330 Recognition and association of DNA glycosylase with site containing an affected purine 319178 319183 319182 232440 319190 57321 319176 319181 234258 319152 18294 21749 497652 21750 319169 268395 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-HSA-8847453.3 Synthesis of PIPs in the nucleus 219024 18718 108083 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 96%1480926 O2 CO2 exchange in erythrocytes 19743 15129 15122 20533 230582 266690 320635 12346 72017 12349 12351 11826 POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels 16514 60613 16531 16533 140492 20928 16519 16520 54393 16518 16516 16521 16522 16524 16513 16515 16517 242425 84036 140493 16534 240444 58802 16526 16527 223604 238076 15165 15168 225030 16535 72413 16538 16539 16497 74571 14697 16512 98741 66733 380728 240595 72258 16528 14710 16490 14699 16491 66066 226922 14700 16492 15166 16523 192775 20927 16485 170738 14708 16506 14706 16504 99738 16493 14704 16494 16498 14695 16495 242151 16500 16502 14693 268345 64337 16508 14709 56543 382571 241794 16510 211468 217826 14701 16511 56379 211480 332396 16499 67498 238271 330953 435726 52150 14702 16525 16530 14696 14688 16536 110862 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction 12291 239556 11749 67938 17904 107589 242202 22004 434246 20410 26903 93689 17880 17898 54195 60596 59310 12391 16419 20411 109700 59069 19303 234889 16952 11669 67268 640703 12306 21894 224105 18479 17907 216459 58226 22330 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 15461 13866 59079 12539 19248 18176 20662 15519 20416 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 21936 12400 18019 12477 16184 20371 16183 15978 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 11370 97212 231086 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 96%4793954 Defective MOGS causes CDG-2b 57377 DEFECTIVE GALE CAUSES EDG%REACTOME%R-HSA-5609977.5 Defective GALE causes EDG 74246 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation 12234 231130 26395 21402 12675 16150 26398 16151 18033 26965 667035 22190 26410 103583 NEF AND SIGNAL TRANSDUCTION%REACTOME%R-HSA-164944.6 Nef and signal transduction 19353 94176 15162 16818 224105 140580 14360 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins 66548 13138 330267 207596 224697 56229 353328 239337 68273 77794 18129 94192 18131 279028 18128 18132 108902 21825 108153 23794 30806 108154 16795 210417 271127 229595 208936 77739 381694 269959 14425 269328 230145 100689 233744 235130 240322 20357 16848 11504 20356 17829 18636 100039649 21826 140474 224116 226866 217734 17063 59048 240913 223838 99011 237360 330119 216725 73732 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 96%397795 G-protein beta:gamma signalling 18796 18797 14702 18795 11848 14696 320207 11651 11652 14697 12229 14710 14699 66066 14700 14688 104709 14708 14706 14704 14695 73341 14693 64337 14709 14701 30955 18479 23797 18607 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants 14183 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification 13479 13087 110198 13077 71522 207182 71670 13114 56615 211666 109652 66447 14598 319446 23887 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events 18796 18797 18795 18710 18754 18755 320127 76192 26413 104418 26417 56077 66082 231871 380921 110524 269060 110197 217480 13139 13649 331374 18176 20662 15461 52666 18708 18709 18706 21390 19419 11550 11548 11549 11820 15560 15559 15558 14675 213788 14697 12671 14710 14699 66066 14700 12669 15465 18241 14708 14706 14672 14704 545156 14695 14676 14693 64337 14709 14682 14701 14702 223435 14696 14527 14526 23945 12229 16952 14688 70086 58861 14459 53978 22044 22045 624910 57260 233571 235036 246709 13617 19734 30044 16438 14715 16439 18798 14714 13615 18441 246691 18442 14745 16963 16995 208188 229214 16440 56183 56696 210198 58182 110651 19204 20112 104443 224065 19216 19220 64214 319239 14816 14289 12374 108071 238377 14744 225642 50778 19735 50780 19736 14829 67168 21333 11606 11607 12061 12062 17392 56470 216749 21338 19737 14064 65086 14063 14062 14061 21337 15200 23832 319197 21334 21336 240816 12424 12425 12426 217369 23939 227717 14065 381810 107221 280287 24111 574402 78134 100043254 237362 385643 433292 246313 233079 233080 233081 50501 67405 18216 14773 54615 12209 78826 114229 15171 110312 18217 387285 230777 14767 68039 18101 56533 18429 11998 18430 54140 26361 22065 22068 20210 26946 18753 110355 18761 19395 207911 20111 13616 13614 13618 18750 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 96%202433 Generation of second messenger molecules 16428 17973 12500 18481 12501 234779 12502 12504 22376 17444 22323 18803 16818 224105 16822 22637 18479 16797 14969 14026 630146 14968 23880 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 96%975155 MyD88 dependent cascade initiated on endosome 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 11909 26419 12675 16476 18033 18035 18036 11820 81897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 170743 14281 12370 22030 12475 67245 225471 106759 18034 54123 434174 66513 93765 66589 22034 66724 68652 20111 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.3 Defective F8 cleavage by thrombin 14069 14061 22371 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9759811 Regulation of CDH11 mRNA translation by microRNAs 233833 213988 236511 217351 17454 214150 12552 76850 239528 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization 14389 74769 56743 20963 18708 18709 17096 14360 18706 20662 18607 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress 12571 12567 12578 SUCCINYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9853506 Succinyl-CoA Biosynthesis 100042811 18293 78920 13382 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism 78038 243382 227095 11992 72039 56357 110446 12040 12041 13171 13382 12039 93747 SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants 16706 20779 12322 109880 12323 108058 12325 26413 26417 12988 109905 640703 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 14161 21894 215449 11836 109689 216869 16452 110135 99571 22330 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 96%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 26965 18128 21402 56438 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 96%69091 Polymerase switching 18969 106344 18968 72151 18971 18972 19075 19076 19687 19718 69263 67967 69745 18538 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 233833 232440 319149 15077 66310 140858 233904 213464 214162 67268 75410 14723 23808 16399 15267 21825 319168 319167 56744 76850 18022 319186 328572 319178 319183 319182 12400 236511 319190 231051 319176 18124 319181 14460 213988 217351 99890 214150 208043 18761 20467 17454 15469 319169 18519 20466 625328 78303 319188 15270 433759 22761 624153 381022 382522 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer 17126 17127 17128 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression 12142 22059 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 96%9762292 Regulation of CDH11 function 12385 110751 12564 12388 12387 12552 57875 16480 11492 239096 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 68652 667035 22190 66513 26409 106759 22034 142980 66724 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69186 Lagging Strand Synthesis 68275 18969 106344 18968 72151 18971 327762 68240 18972 14156 19075 19076 19891 19687 19718 69263 67967 16881 69745 18538 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL 74769 18707 12402 17096 22612 22324 20963 107746 18710 12929 15162 12928 17060 18708 18709 14360 18706 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 11881 65973 14068 71952 66632 13495 102115 58911 63828 107817 22021 276770 271970 56316 14058 69082 14071 67902 66901 22022 665189 69740 13494 194952 545260 269955 57295 238024 11883 77035 67014 67228 66521 105638 99349 74008 77041 270086 208691 330817 67728 116905 14061 18550 19123 667739 14069 19128 100038875 14456 13629 225363 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR 18053 18049 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450520 HuR (ELAVL1) binds and stabilizes mRNA 15568 11737 69583 671392 18753 18750 227720 103573 HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation 276770 208691 102115 330817 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 96%9694493 Maturation of protein E 667035 22190 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade 317677 71756 12759 12630 93721 12273 12274 545366 12259 17221 56373 12260 12902 12262 109828 12267 50701 14061 15139 14962 12263 12266 625018 230558 22370 319430 19128 333883 12258 110382 12478 12520 69379 12279 667277 50702 12628 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856828 Clathrin-mediated endocytosis 58194 20408 12402 215114 56324 15239 20404 20844 20405 13858 103967 104015 13649 12500 21802 12502 12638 12504 14269 12848 214459 109689 216869 100043806 26891 11607 238055 12223 71920 13874 20508 15200 21336 22320 26893 17113 74325 26894 15481 20955 18002 108679 13430 26572 72685 26895 16004 20980 19345 271457 22041 11839 19344 22318 20979 13645 22042 11998 53330 11555 12000 320634 22319 667035 22190 243764 16443 110355 100017 26754 13132 13043 73094 14366 229521 76709 194590 73178 210108 233489 22418 11771 218503 11772 30931 228998 71770 18704 56443 30934 74015 13854 66691 108800 80708 66616 20616 20403 68089 13855 67771 231580 11845 67602 56378 15463 18717 66713 29816 232910 74117 56017 11773 218038 30948 16835 13859 320129 12492 60510 269774 23969 20975 106628 13543 14725 16197 55925 66147 23970 67300 13429 170625 54609 12757 56085 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 96%1614517 Sulfide oxidation to sulfate 27376 22117 59010 211389 226654 66071 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones 216848 20602 319149 107932 15077 170787 19646 234366 19712 245688 621893 23942 17192 319162 15267 319173 319163 319168 319167 229542 319186 319178 319183 319182 21372 319190 319176 319181 50724 81004 60406 56310 70315 99982 217864 15183 116871 20185 94246 116870 100041953 71954 107392 238247 15353 319169 78303 319188 433759 319189 15182 382522 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 96%9856872 Malate-aspartate shuttle 68267 71803 67863 14719 78830 14718 50799 17449 17448 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9692912 SARS-CoV-1 targets PDZ proteins in cell-cell junction 56217 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 96%177135 Conjugation of benzoate with glycine 435528 107146 117147 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription 14103 14377 16334 12575 109648 18044 56458 22628 18045 18046 110616 11651 12389 11652 433766 12576 76184 100039786 54401 55948 14815 17126 17127 17128 67731 20787 22166 243743 56338 12053 12359 16600 328572 59092 17684 54601 11604 19017 16006 15228 20869 93759 103988 12914 57264 17700 18519 22631 13198 13197 12452 20466 20656 56484 18976 433759 64384 19651 15182 12125 23797 68943 12226 18534 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint 56299 56436 29870 17463 57296 12534 20422 26445 12575 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 13589 67089 70247 15519 22059 21762 12442 22123 19179 19181 19182 23996 19184 18817 26440 19166 19167 26441 26442 69077 15516 66997 23997 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex 68953 105513 75608 56208 66383 67443 225326 78610 208092 75669 66371 66700 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 96%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) 117591 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%774815 Nucleosome assembly 319178 319183 72155 319182 232440 319190 217653 20892 233532 100038822 70645 319176 66311 66578 319181 12617 83815 12615 18148 66570 56505 19646 70454 67733 71876 76464 245688 320394 102920 319169 60411 66336 93762 78303 15267 319188 15270 319168 69928 319167 26886 52504 624153 319186 382522 VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.5 Virus Assembly and Release 12330 12317 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 96%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 319178 319183 319182 232440 319190 319149 319176 76804 319181 17978 320795 15077 99982 11835 319169 625328 15267 78303 319188 319168 15270 319167 624153 319186 382522 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839126.4 FGFR2 mutant receptor activation 14172 80857 14180 14178 14177 67112 68092 64654 14175 14174 14173 433702 14164 68705 98053 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 14183 80903 14165 PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9033241 Peroxisomal protein import 16922 71382 12908 17117 67528 66105 13142 74114 667035 110959 22190 70503 18126 11430 228061 224824 18634 15112 28200 56185 80911 71767 76263 13850 12012 15925 111175 19193 93732 20280 51798 74043 171210 11611 212503 17527 65098 56794 12359 22284 100041766 56273 668173 103737 72129 19302 14712 74147 171282 26458 15488 15926 113868 170789 26378 216080 15356 66887 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%R-HSA-982772.3 Growth hormone receptor signaling 16367 15170 11491 12702 17096 20846 20851 20848 20850 14600 19116 216233 12700 19246 384783 12703 26413 16452 26417 19109 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112307 Transmission across Electrical Synapses 14615 14610 55991 14617 406218 INFECTIOUS DISEASE%REACTOME DATABASE ID RELEASE 96%5663205 Infectious disease 56208 66383 67443 74153 78610 22201 74244 12389 18126 22325 100042069 23917 57257 171210 19877 15381 231380 11465 22352 19298 19878 70233 67224 378425 19655 218978 218035 15516 73075 66999 269061 70616 66892 68598 67959 12609 17395 672511 100040603 232989 269338 107701 67480 66286 72047 74326 67500 56298 17755 18452 16172 75956 18550 66861 56031 80744 69550 218490 22365 66101 19035 66270 70225 69019 18451 13684 80743 18655 68879 28185 320632 208643 67418 212880 66585 108098 74351 83486 74370 216705 66877 56529 23983 18521 83701 12695 57905 224912 68479 56217 77573 56216 13690 20980 15569 64176 209416 22317 66172 64051 20222 22318 320452 20614 67838 20979 60321 20907 50884 192191 75209 24088 83767 21897 14469 329165 78334 17713 257630 71893 66070 23845 66810 319322 12282 20683 105855 233726 66397 242687 19205 27967 20933 76936 171095 12412 69608 237038 15006 218811 71702 27061 99683 11308 68981 20639 229279 235623 240095 667803 241275 23881 13057 101943 108100 81898 67439 94315 20646 27041 101314 381379 14991 192159 71514 77371 23806 11993 55932 20334 67219 170779 21899 20390 53317 15382 70686 170761 53379 56258 66371 59013 98758 11991 68953 217365 16176 11834 75608 234852 12362 20168 15388 18571 15387 12363 12785 15162 228545 12526 66055 140580 17002 16396 236573 208092 68816 81910 66700 230861 19766 76199 67197 56532 213539 22230 54633 16173 109637 67465 17075 66624 56445 73158 69192 12721 19088 71732 69146 234779 53902 17918 14827 19108 67285 12499 236732 12267 223697 76709 67958 73178 68183 105513 104110 76479 16175 20963 20624 14678 66642 14677 233405 12229 64685 56443 68137 14687 75062 19200 77134 14679 27366 432530 228005 210044 76687 104111 13205 80987 28000 68089 13204 67771 246728 11867 76938 54483 16171 56378 233908 18438 66125 66713 74117 13542 70086 224129 245880 11512 11513 11514 11515 14191 13544 13543 22376 215280 14598 18439 319446 68524 67955 13035 11541 23959 23887 17882 14129 242851 19085 17913 13479 11931 58861 246256 11932 14131 11933 17909 66824 330319 216799 76884 12495 56188 19720 12322 12323 108058 12325 16881 229709 16438 16439 18747 11928 98660 232975 57780 16440 59095 108017 12527 22166 26400 26398 16193 15977 26419 18803 12048 13629 11491 107686 384091 666609 216766 621705 20595 66603 53975 192656 276919 20641 20638 69731 432803 67332 257632 12266 625018 107607 14917 108960 103534 57377 27801 228136 75965 70546 108687 269181 57437 217664 69035 107895 20446 20444 20442 20443 17308 17158 20440 67569 14376 20447 71164 53618 20448 227619 69940 19089 208884 107338 217344 20620 93671 16153 17886 70625 68975 234959 94112 70208 21849 13649 55948 23942 56771 50493 80509 22154 56310 26896 16834 216848 107932 18148 100039786 19712 229542 24127 67279 21349 99982 14228 13207 100043508 18854 59024 327987 192292 11350 17127 17128 17192 69790 22608 21762 22123 12675 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 14156 26446 19172 19173 19175 19697 13682 19177 13681 21402 16150 26443 26444 16151 19170 66413 16179 667035 22190 59029 26409 67089 75613 70247 14815 22196 621893 16401 319162 319173 319163 170743 56338 170744 264064 142980 317677 17195 12259 83814 72512 54123 22596 13211 14375 214763 216154 51813 15469 69792 67381 15182 12388 12387 20602 58194 12550 23989 20408 12402 56324 20779 15239 20404 17295 20844 20405 13858 104836 26416 12928 234366 26413 26417 28077 54401 171285 26395 26396 20662 19014 16452 328572 15129 17087 15368 15122 21372 11806 103573 81004 21898 18024 15183 20185 108664 12914 640703 268373 14225 16476 66899 22627 56480 54131 58203 56438 14697 14710 14699 66066 14700 14708 14706 14704 14695 14693 64337 14709 108138 14701 319583 14702 14696 18453 16453 16177 22418 11771 54721 11772 50724 60406 71770 13609 20847 15980 17060 15979 58799 12518 14369 217864 15985 15975 94246 14688 18391 100041953 110606 26554 71954 107392 14272 232910 238247 11773 15353 68219 98985 228410 54451 108062 110611 67337 83410 18789 18749 51786 94230 74320 68188 19645 13163 15529 216965 23888 20971 234663 19047 19386 20969 68097 71951 20970 14735 445007 57294 56455 15530 13806 103978 14733 69912 76246 214498 103468 66317 235661 235497 14734 234865 22083 59015 54624 69736 17069 110379 68032 17289 13427 14828 19128 276891 13426 217303 22174 13424 14456 26362 17533 100732 52898 12737 21872 68705 98053 13871 225913 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 11603 231329 20021 69241 66671 17749 100043714 101772 24018 17420 67897 12572 13872 20924 23894 14884 15267 102566 404545 319168 319167 224105 105722 382014 319186 319178 319183 319182 320091 319190 12475 22031 56489 56717 319176 18034 233246 319181 19353 20014 57261 103963 243634 56637 69038 227743 13135 19247 116871 51810 116870 14056 15170 319169 109270 67075 20846 14423 214424 328417 78303 606496 319188 67287 80285 52552 16818 671535 547253 80286 56716 68292 19092 23797 16430 382522 16451 13200 13626 319149 18108 22628 19084 22612 11651 11652 22324 15077 269523 18566 52615 107305 72543 19646 27681 70160 14360 194309 52348 116733 73711 13001 22088 13000 67123 100039026 330192 28084 245688 76959 66201 20479 66914 12502 17096 12504 18005 233870 78757 100088 12774 18708 19385 18107 18607 66357 12487 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 229906 235459 24074 83602 58202 68153 74197 67923 27224 71586 27632 230073 24116 66641 12455 71956 72949 228607 13716 217069 63856 20817 14609 20815 16001 13051 19345 271457 19344 93687 170786 11461 19349 16412 140579 94176 330662 170762 108989 231042 227699 223921 20430 227720 269113 66679 18141 23825 107939 69482 71805 11739 433923 11740 54563 16646 19069 15361 70699 101739 72787 19045 18226 218210 19046 27207 67097 670832 231413 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 14083 21803 20103 668668 667739 54188 67300 672214 12757 66481 225058 100038875 17925 100038991 68028 100043000 67891 100043295 18458 622534 238217 74568 16785 17973 666669 100040021 67025 12767 100043391 668182 241053 12317 18186 432502 100038882 19087 19989 76808 19899 100043184 19921 19934 100043755 11545 193740 12330 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 16211 100039592 16648 19106 100037258 100043876 100043893 100043423 100042986 20115 67281 54196 76846 13480 625646 100040298 68172 13481 100042740 19951 381686 16649 70572 19384 667618 100040970 267019 56040 67248 100040331 67941 68563 14104 50528 70008 171283 14061 13712 15200 64340 11840 622469 225027 15481 67996 51796 71713 233073 20382 110809 20383 21681 12846 108014 192170 69207 19826 75669 81897 100040029 225326 16194 69116 15568 22370 15007 12010 11768 11769 108012 11764 107975 11765 11767 252903 12759 56791 100041766 66513 93765 66589 22034 66724 68652 50868 22200 22631 75717 22629 66663 433759 22346 319189 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME DATABASE ID RELEASE 96%3656237 Defective EXT2 causes exostoses 2 15529 11603 23888 20971 14043 14042 20969 15530 14734 103978 71951 20970 14735 14733 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 13709 12400 16880 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins 11684 11689 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 11727 68626 192119 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%156584 Cytosolic sulfonation of small molecules 20887 22021 76491 56362 319655 20859 242291 22022 20860 23827 73671 29859 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 20924 23894 14884 68092 433702 20922 20833 67655 21399 107951 57314 114741 76246 214498 12454 66317 58202 235497 67923 22083 27224 27632 24116 12455 72949 54624 13716 64144 20926 93736 70122 74427 73473 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 96%1300642 Sperm Motility And Taxes 329954 212670 271036 16532 106757 225865 74096 320225 76856 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013419 RHOT2 GTPase cycle 67095 67414 70827 214952 229877 170731 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%8875878 MET promotes cell motility 20779 17295 19353 107746 16398 12929 16400 12928 109905 16412 16775 16776 16777 16779 16780 14388 15234 226519 14083 16782 16772 23928 16773 16774 215449 319939 217169 67299 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation 66341 26885 17342 109113 223701 100040573 67241 20602 66647 18854 67872 67040 320213 20230 56459 50995 55989 68501 19720 226026 17190 75826 223870 224903 21973 11545 21974 21969 13163 52615 12419 240087 56233 21849 19106 19386 21420 11799 21419 52276 15381 20842 12418 16319 57320 20877 24061 214669 445007 19357 12151 328572 19763 17246 54383 13619 17977 19017 241915 12416 17978 26370 19821 268903 15258 69912 12578 13006 12914 103468 22591 234865 30951 59015 69736 110379 13016 18035 20843 69260 216848 19697 16151 18148 22260 20181 22337 70238 19013 13436 27223 56469 13435 19365 13982 13433 22025 19883 11835 18227 14815 22059 59004 20610 208727 19016 22196 108138 100043429 110784 26423 19401 15204 229615 21834 15387 18667 170762 108989 231042 227699 223921 227720 269113 66679 22658 18141 107939 69482 71805 54563 56489 22427 19069 70699 18034 72787 18226 218210 12189 18538 12144 116870 68275 13207 106021 20687 15248 26927 212712 20878 20466 433759 22346 15182 67711 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 96%5654708 Downstream signaling of activated FGFR3 327826 14172 80857 14180 64654 14175 18176 14388 20662 14173 14164 15461 107971 18803 80903 18708 19247 18706 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 96%9008059 Interleukin-37 signaling 320139 56294 19255 56480 15170 19258 17127 20848 12362 19248 19249 19250 19253 104831 19259 19247 19256 16182 24058 16068 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME DATABASE ID RELEASE 96%442729 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde 207565 100039592 640703 12323 12326 12325 55984 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 20201 20202 11909 26419 12675 16476 18033 18035 18036 24088 11820 21897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 21899 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 22030 12475 67245 18034 12229 434174 66513 93765 66589 22034 66724 68652 20111 12703 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease 72544 50911 66317 69639 72662 66446 227715 218343 56422 68106 69305 66362 109075 108077 66583 27998 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 96%3214841 PKMTs methylate histone lysines 13626 319149 231051 110147 19697 18034 15077 66310 140858 70673 226830 233904 52615 208043 107823 19646 213464 214162 14056 245688 75410 69726 208266 232811 23808 239122 54343 11569 213389 67956 66083 52690 77683 18033 18193 14013 20937 192195 73251 225888 64707 84505 234135 235626 381022 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-HSA-1614558.10 Degradation of cysteine and homocysteine 246277 14261 12583 211389 14719 66071 73748 107869 27376 246221 211488 22117 56551 59010 226654 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 96%1237112 Methionine salvage pathway 56369 104923 66902 67870 67873 14718 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME%R-HSA-9711123.6 Cellular response to chemical stress 67443 20602 12575 216799 13666 11651 11652 269523 27401 13001 13000 100039026 17869 50493 22166 19014 229003 20657 14630 76408 328572 66401 15129 14780 14778 15368 14775 15122 26462 12013 67305 21372 12460 109151 11833 11911 17977 11927 20293 69590 76650 17436 17135 75221 17978 50527 59035 14950 81004 17134 66993 18412 27407 75512 68350 14776 56551 18104 11758 18024 14859 11757 15369 140742 15183 224111 20185 109778 233016 71389 12578 106766 12914 667310 14629 56406 12858 26357 12857 21762 22123 19179 19181 19182 20656 23996 110323 21351 19184 18033 230784 26440 18477 19166 11839 12861 21672 12043 20463 19167 18590 13645 26441 12048 12862 26442 69077 12868 66997 23997 66142 14381 12234 56436 20459 17463 12866 57296 12865 20422 26445 100041785 26446 20683 19172 19173 21881 19175 17250 72345 19697 17969 19177 18128 21402 56438 26443 26444 19170 18759 66413 13058 26965 667035 13057 22190 333182 59029 17970 67089 17972 70247 110208 17708 20181 17709 17710 19013 11977 18753 20821 217365 56338 380975 12359 84682 22230 670717 50758 17992 18453 12189 50490 56637 11657 26554 14080 50868 233826 26570 108079 20466 20848 15926 23797 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 96%9683686 Maturation of spike protein 19089 12330 17308 57377 14376 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 327826 14172 80857 14180 14178 14177 67112 64654 14175 14174 14388 14173 14164 80903 18708 19247 14165 18706 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 96%187706 Signalling to p38 via RIT and RIN 18211 109880 18049 19762 19769 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis 12385 12387 26399 21423 17260 12558 17261 26416 17258 29857 21406 11350 70834 12555 12386 19094 21413 17877 17878 12175 18209 57810 12561 17927 17928 18007 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%199920 CREB phosphorylation 17164 20111 73086 110651 20112 100040260 DEVELOPMENTAL CELL LINEAGES%REACTOME%R-HSA-9734767.4 Developmental Cell Lineages 21802 14178 16775 16776 16777 14175 16779 16780 14173 226519 14268 16782 16772 23928 16773 16774 11839 22370 13645 14165 19109 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 217666 76187 98314 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 233833 232440 20375 18854 319149 67155 20586 20779 20588 12571 20587 12443 12444 12445 15077 66310 21936 241196 67296 140858 233904 12005 213464 83766 214162 11350 13001 67268 13000 100039026 75410 22601 14723 23808 12418 76073 12741 21825 56744 12477 12151 69257 328572 13709 12143 19763 13038 18507 12400 13039 54383 231051 13619 239985 12702 241915 14462 56456 12416 16854 18124 14461 14460 22062 66993 99890 19821 72780 208043 15258 12914 494448 16880 93760 66923 18019 21762 30951 22123 19179 19181 19182 23996 19184 26440 19166 19167 17863 12981 26441 26442 69077 66997 381022 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 21872 14732 21423 19170 66413 667035 22190 18751 59029 67089 16184 21406 70247 16183 66671 13982 17420 12572 319974 16399 68094 83796 15267 83797 57376 319168 319167 16396 76850 18022 239528 319186 15978 319178 319183 319182 236511 319190 67057 319176 20371 319181 56353 213988 217351 214150 21349 19247 18761 20467 17454 15469 319169 18519 109594 20466 16909 625328 78303 16825 319188 15270 433759 22761 624153 71393 77044 382522 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%421270 Cell-cell junction organization 233833 16451 20665 12388 232440 19089 12387 13200 13626 12550 319149 20586 20779 13858 15077 104836 13345 12558 21417 52615 19646 26413 26417 21418 22325 13001 13000 100039026 17869 245688 18109 209462 22160 16480 16452 22330 66357 224619 66286 228839 18550 18553 69019 93759 226970 56529 12695 224912 56217 13017 13016 16456 20683 93742 56513 330662 56198 140580 77630 11492 239096 11797 12385 59058 110751 12564 15426 66624 16201 330914 20613 12552 57875 15227 11798 54721 99982 76687 228913 11727 217734 99011 11735 19645 12330 20901 60611 16601 114142 12741 16600 53325 17246 16193 12555 93760 13430 12561 21762 22123 19179 21844 19181 19182 64945 67956 23996 71740 19184 105837 18033 58235 26440 19294 19166 94332 71908 19167 15220 60363 26441 54420 58187 26442 54419 69077 12738 66997 93737 23997 54725 56863 12737 56436 75677 17463 215654 57296 320873 20422 12565 24136 26445 241201 26446 12563 19172 53624 19173 12562 19175 12739 15376 19697 12740 19177 12560 12557 12554 26443 56492 26444 16195 22431 19170 621628 21423 18759 14694 75339 66413 330222 192173 667035 56173 22190 239857 242653 239931 59029 230738 18746 16194 67089 76007 56805 70247 58220 21406 237979 21885 58998 18554 227485 18417 227377 114141 75234 15267 319168 319167 13040 13030 76850 239528 319186 319178 319183 319182 236511 319190 319176 319181 19353 20014 213988 103963 217351 214150 69038 13135 20583 14056 18717 17454 319169 57377 20848 625328 78303 319188 15270 433759 624153 15182 16430 14376 382522 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex 68652 17087 12475 225471 106759 108960 667035 21898 22190 66513 26409 22034 66724 INTERFERON SIGNALING%REACTOME%R-HSA-913531.6 Interferon Signaling 16451 56208 12534 74153 13666 20892 19043 17999 26413 26417 55948 110157 11465 17750 16362 16452 66892 12702 18550 69550 13684 208643 71586 230073 228607 217069 13690 14469 54131 15006 240095 18148 667803 11461 14991 23806 55932 66369 22059 12362 19246 20698 170762 108989 236573 231042 227699 192176 223921 230861 227720 269113 66679 18141 107939 23988 69482 71805 16201 16363 54563 16646 19069 70699 72787 18226 218210 18712 54721 14229 20847 15980 15979 15975 246728 110606 14272 14129 17973 18854 100038882 12322 12323 193740 108058 12325 17967 19255 16211 100039592 16648 19106 100037258 19386 73699 19204 19052 19053 381686 51792 16649 17131 12505 445007 226849 26399 24015 69912 15481 22608 103468 15977 234865 12675 59015 69736 27056 110379 18803 69928 14828 192170 13682 13681 16150 23992 16364 21357 16151 667035 22190 24110 56469 12265 80876 74735 18753 22329 20821 19824 23960 225467 67781 22196 65972 229900 246727 56045 17318 56417 231655 93679 66141 15007 224762 12010 13665 286940 67204 67525 58185 70110 26905 211948 15512 15482 15978 54139 57444 52668 56791 67513 67030 55992 667370 101700 112419 15958 76500 101831 24014 13653 15061 104806 94088 80890 16913 360213 54123 20617 56631 16391 226641 13211 71885 22670 319236 93765 14087 19247 15894 214158 14969 229644 14968 100040608 237211 15900 72775 229898 66854 14088 15170 60534 20846 20848 12703 22194 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 96%2555396 Mitotic Metaphase and Anaphase 52717 99152 668450 12534 238799 116733 30939 100088 98386 103573 22147 16906 22151 22143 53857 22152 227613 22153 22142 22146 67951 73710 13726 22145 66371 71782 545486 238463 68953 75608 170762 227699 208092 66700 380664 269113 23825 107939 69482 71805 70699 67141 72787 18226 105513 71978 108911 73470 16563 75786 70454 216965 71876 16211 234663 19047 66977 320394 19386 102920 73699 11799 52276 218914 12235 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 19384 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 100710 108000 229841 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 21762 12442 22123 60411 66336 59015 19179 69736 19181 67052 19182 232987 23996 12236 19184 236930 110379 26440 69928 19166 13427 76499 19167 71521 13426 26441 52504 13424 26442 228421 69077 20843 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 22196 22367 71955 64383 224640 319965 105988 50850 100042651 217232 56317 59008 18817 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 TBC RABGAPS%REACTOME DATABASE ID RELEASE 96%8854214 TBC RABGAPs 93739 22241 54189 227800 66687 67443 207592 19326 70296 67231 106039 71648 17274 19349 64930 11845 22084 53869 68449 381605 67046 100855 19341 56486 108995 270192 19345 77407 271457 19337 19344 269589 74105 224617 19346 260302 235442 233204 56715 103724 19338 209815 ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 96%1482788 Acyl chain remodelling of PC 18778 14792 329502 66857 271844 67452 237625 665270 270084 53357 67216 68255 232889 225845 18783 18779 26971 99010 210992 26970 26565 18784 18782 78390 66350 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME%R-HSA-9022534.2 Loss of MECP2 binding ability to 5hmC-DNA MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 96%9636667 Manipulation of host energy metabolism 18655 13806 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 96%9627069 Regulation of the apoptosome activity 56369 670717 11783 74268 72565 66593 12371 26413 11798 26417 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling 14103 14082 12370 14102 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation 21374 67065 71752 74414 233863 66420 72308 69833 66596 227644 78929 245841 66653 544971 77634 70239 20841 18986 269252 102209 26939 330959 67486 75627 70408 20018 69870 70428 67371 17749 218832 100043714 67005 20016 98488 12909 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 96%2428924 IGF1R signaling cascade 14389 74769 16367 14172 80857 18576 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 327826 16370 16002 16000 18176 14388 20662 15461 16001 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 18607 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 96%9819196 Zygotic genome activation (ZGA) 328572 12914 21679 100043167 230594 547035 214290 22601 22059 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390650 Histamine receptors 225192 15466 15465 99296 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME DATABASE ID RELEASE 96%2033515 t(4;14) translocations of FGFR3 14184 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.4 Hh mutants are degraded by ERAD 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 216440 26444 19170 269523 66413 667035 22190 59029 67089 70247 66753 116891 20338 74126 21762 22123 20423 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 96%429947 Deadenylation of mRNA 78893 69125 18983 74108 13682 13681 52846 231464 58184 75705 13684 208643 230594 234594 214290 218693 103135 72587 53621 72068 232791 104625 228140 192170 18458 SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000471 Scavenging by Class B Receptors 12491 18477 434174 11806 20210 238055 11801 269855 20202 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-HSA-453279.6 Mitotic G1 phase and G1 S transition 17187 12534 12575 211586 13555 19645 21781 12571 12567 12443 11651 12566 11652 12444 12445 13557 12447 242705 21973 27401 12448 12577 20135 12576 19646 12545 11350 17869 73699 17096 13548 22171 21877 13361 19052 19053 51792 16452 12428 17216 17215 17217 17218 17219 17220 12544 100043858 12580 12579 12578 50496 13559 104394 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 19650 26441 19651 63955 22390 26442 17865 72568 69077 66997 12530 231506 23997 629959 54124 56436 27214 20459 17463 67177 75660 57296 23834 20422 26445 26446 57441 19172 70024 19173 19175 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18969 18968 66671 19075 19076 17420 12572 59001 67141 66979 50793 18392 18393 66634 26428 26429 56452 18538 68275 68240 19891 18973 18974 71978 433759 23797 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux 328572 233833 20602 236511 21372 17977 11307 22259 11816 11303 213988 81004 217351 214150 56310 99982 15183 20185 22260 20181 20182 17454 11812 11813 11425 67470 27409 67484 218214 11815 320982 230674 104263 76850 239528 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%500792 GPCR ligand binding 17202 17201 22094 12640 140498 212108 19773 242093 381489 239336 16336 23919 21390 11550 11548 11549 11820 11554 11555 11556 15560 15559 15558 213788 15557 13492 57265 382348 13733 13491 381853 13490 14607 13489 22226 13488 14697 111174 93897 215855 19206 503558 54598 215854 22412 12672 216795 12671 19226 15552 14710 15466 14699 15551 66066 15550 14700 243764 22410 12669 93896 15465 22414 99296 22411 18241 14708 209512 14706 15566 22409 15565 12310 15563 14704 15562 11516 225192 14695 14652 11517 12311 14693 20423 64337 14709 15874 12921 12919 22417 12918 14701 114640 223780 54409 19227 19228 56089 213527 51801 13363 14602 14601 319757 11535 14702 93735 83428 14696 14527 14526 14367 14365 26364 14362 22415 14366 22413 12267 22416 22420 22418 14370 22354 22422 13609 14371 22421 22353 20287 14368 22423 14369 22355 20890 19207 14688 22408 16147 70086 11541 58861 20293 54393 242425 18429 11998 18430 54140 26361 12000 212541 20210 15139 12266 207911 14419 12772 12774 12768 80901 14747 84112 20607 387512 59289 12776 12775 12458 12773 12771 170458 18386 18389 14539 23925 19214 243270 239283 387513 19222 14427 19217 18166 19218 19219 18167 18168 14294 12802 14293 12801 14309 387353 387515 353148 12765 227288 14308 56838 57811 17773 244701 353165 387348 387356 19156 20605 19065 20606 19064 211578 80885 272031 12145 20609 20608 14428 13051 227289 75769 217212 208990 216152 22439 110326 83770 20132 140795 57349 17171 30878 623503 107522 17329 20290 17200 18155 55985 20303 109648 20304 12057 20306 20296 20292 20302 57385 20295 20297 100039973 74191 100038965 20299 13610 56066 20311 20312 20300 11539 11540 18610 18619 229791 235044 11542 252837 66102 13611 22095 330122 14823 108073 268934 94226 108069 108068 20310 14825 353344 14429 14764 13603 11609 23796 83771 574417 387347 57253 12777 57254 387355 387342 387349 226278 12766 226304 387616 321019 12778 381073 110168 75805 436440 76854 12769 64095 15199 230857 14763 54199 70839 171469 16866 16867 227326 14739 12854 13349 16952 15945 20315 12767 53978 22044 22045 57260 233571 235036 13617 30044 14715 14714 13615 18441 246691 18442 14745 16963 16995 208188 229214 56183 56696 210198 58182 19204 104443 224065 19216 19220 319239 14816 14289 12374 108071 238377 14744 225642 56744 14829 67168 21333 11606 11607 12061 12062 216749 21338 14064 65086 14063 14062 14061 21337 23832 319197 21334 21336 12424 12425 12426 217369 227717 14065 381810 107221 280287 24111 574402 78134 100043254 237362 385643 433292 246313 233079 233080 233081 50501 67405 18216 54615 12209 78826 114229 15171 110312 18217 387285 230777 11551 14767 11552 68039 11553 18101 18387 18390 319430 12273 20604 13616 13614 18976 17199 13618 17203 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%205043 NRIF signals cell death from the nucleus 67733 26419 19164 19165 100042305 18053 208117 18412 59287 100039623 667035 22190 18049 22034 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764274 Regulation of Expression and Function of Type I Classical Cadherins 233833 12388 232440 19089 12387 13200 13626 11735 12550 319149 20586 19645 20779 13858 15077 104836 13345 12330 20901 21417 60611 52615 16601 114142 19646 26413 26417 21418 13001 13000 100039026 17869 245688 18109 22160 16480 22330 16600 66357 53325 17246 66286 228839 18550 18553 69019 93759 93760 13430 21762 56529 22123 19179 19181 19182 67956 23996 19184 105837 26440 13017 19166 13016 19167 15220 26441 26442 69077 66997 23997 56436 17463 57296 20422 24136 26445 26446 20683 19172 19173 19175 15376 19177 26443 26444 22431 21423 19170 14694 75339 66413 192173 667035 22190 59029 18746 67089 76007 56805 21406 70247 21885 18554 15267 319168 319167 13040 13030 76850 239528 319186 12385 319178 319183 319182 66624 236511 20613 319190 330914 319176 319181 20014 213988 103963 217351 214150 69038 13135 99982 76687 228913 20583 14056 18717 17454 319169 57377 625328 78303 319188 15270 433759 217734 99011 15182 624153 16430 14376 382522 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-HSA-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane 66357 16451 13200 72297 67075 20014 103963 60533 58205 76580 18566 69038 80286 13135 68292 16430 G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation 14708 14672 14706 14702 14704 14696 14695 14676 14675 14693 64337 14709 14697 14682 18976 14701 18390 14710 14699 18610 66066 14700 14688 HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.7 Hyaluronan degradation 114332 15366 56398 15587 192188 20544 235504 110006 77042 15586 80982 109685 12505 15212 15211 74468 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702632 sunitinib-resistant FLT3 mutants 14255 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022928 HS-GAG biosynthesis 14043 14042 15531 15530 103978 54710 628779 54616 58193 50785 14733 70484 83398 50786 23908 15529 11603 23888 20971 93683 20969 14734 64580 15476 15478 195646 71951 17423 20970 328779 14735 50787 319415 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 67422 52014 KILLING MECHANISMS%REACTOME%R-HSA-9664420.3 Killing mechanisms 19353 13543 71893 22418 16476 241275 13542 13057 26419 14369 237038 13544 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%5654688 SHC-mediated cascade:FGFR1 80857 14180 14177 67112 64654 14175 18176 14174 20662 14173 14164 15461 14165 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation 56436 17463 57296 20422 26445 26446 19172 19173 19175 17969 12317 19177 16150 15006 26443 26444 16151 19170 22319 20619 240095 17874 66413 667803 13058 667035 13057 22190 59029 17970 67089 14991 17972 70247 117149 12491 21899 20193 14161 15007 13040 12010 110135 99571 17087 16912 13039 19171 12475 14827 16419 16913 19186 12229 19188 434174 57743 21898 17534 22320 21354 21356 21355 53421 20909 20201 240028 100043039 20202 246278 66212 20333 21762 22123 12675 16410 19179 19181 19182 23996 19184 26440 19166 19167 26441 24088 26442 21897 69077 17533 14129 66997 23997 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME%R-HSA-5619035.3 Defective SLC17A5 causes Salla disease (SD) and ISSD 235504 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound 13823 17913 227357 192140 13409 238021 628870 332309 18419 97031 80979 20742 17524 56506 102502 224796 72088 67972 98845 328789 56226 60613 16531 433899 16533 13860 17886 140492 329421 504186 227753 22350 19230 19339 13002 20964 56808 12296 240899 83762 26875 12343 12345 12217 12289 216227 29866 20977 12340 231252 241431 73750 12361 140476 16470 17910 22318 19684 23999 20614 22295 17921 20907 17698 667663 381375 193385 20776 20740 11994 SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 328572 233833 236511 20683 14173 21423 213988 217351 21812 21813 214150 21406 20181 21413 17877 17454 17878 21858 17927 21857 17928 15201 17127 16323 17128 19164 16322 18109 19165 21814 21803 21808 100042305 118445 208117 67903 19401 59287 17387 100039623 11480 17389 109689 216869 76850 239528 PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964208 Phenylalanine metabolism 18478 70266 14204 110391 13180 66514 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 96%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) 20525 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs 16998 68010 17872 320910 65112 14479 108075 16420 56424 170749 56207 12402 241226 19045 103573 83814 16419 18550 21812 19046 667035 21813 22190 20901 18002 19047 16412 17126 14225 17127 17128 16410 22192 16416 21814 21803 21808 75788 66313 17131 21809 268977 16997 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling 13866 211323 667035 22190 84092 100042150 23797 11651 67588 11652 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963888 Chylomicron assembly 17777 66397 11806 11813 11814 238055 11807 11808 18453 11816 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 319625 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression 232440 319149 667501 57230 21429 20019 269003 15077 21340 17191 21339 21341 64424 22130 13871 75316 66420 70333 69833 116848 66136 245841 20017 14885 209357 66467 13436 66671 13433 17749 100043714 17420 12572 13872 23894 14884 93762 15267 319168 319167 319186 319178 319183 319182 319190 319176 21374 319181 50724 60406 94246 20467 100041953 20018 71954 20016 319169 20466 625328 78303 319188 15270 433759 15182 624153 382522 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 96%2214320 Anchoring fibril formation 16782 16774 24087 21892 12836 12153 16780 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717329 lorlatinib-resistant ALK mutants 11682 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME DATABASE ID RELEASE 96%9845621 Defective VWF cleavage by ADAMTS13 variant 279028 22371 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a 14423 20448 20446 20444 20442 20443 20440 20447 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes 29813 59092 12575 22059 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress 269523 12322 12323 193740 108058 12325 26413 26417 12955 15499 15519 72630 56354 50497 12017 81489 70356 67669 219158 19386 29810 18415 110920 67384 66538 70369 23950 15525 15505 17164 68196 22791 80888 73442 170762 108989 231042 227699 223921 227720 15516 445007 269113 15512 66679 15482 18141 328572 213539 107939 69482 71805 54563 19069 56717 70699 72787 11920 18226 218210 15185 56637 14228 69912 93759 15481 68275 12914 103468 68240 19891 74370 234865 100043508 67605 59015 69736 15526 110379 14828 22627 56716 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER 56438 70620 26370 77593 11545 13871 68058 667035 22190 93765 93836 14885 209357 66467 11546 13870 68275 56469 66671 19358 68240 19359 22590 19891 17420 22591 107986 12572 22592 13872 50505 20610 23894 14884 22196 100043429 229615 99375 72584 13194 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death 56532 17087 21898 12475 14082 225471 106759 12370 19766 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163358.7 PKA-mediated phosphorylation of key metabolic factors 18747 18639 58805 18749 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) 13162 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 96%1169408 ISG15 antiviral mechanism 16451 56208 74153 54131 13682 13681 19043 100038882 667035 22190 17999 24110 26417 23806 16211 100039592 16648 19106 19386 381686 16649 170762 108989 286940 231042 227699 223921 227720 445007 230861 269113 66679 18141 66892 107939 69482 56791 23988 71805 54563 112419 16646 19069 70699 72787 18226 218210 93765 69912 13684 103468 208643 234865 230073 20846 59015 217069 69736 13690 110379 18803 192170 22194 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 96%171007 p38MAPK events 15461 17164 19094 26416 102626 19730 56044 64143 26415 18176 29857 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) 22318 DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system 58992 16621 12258 14061 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 96%156590 Glutathione conjugation 14866 68312 100042314 14874 14871 68044 68214 71522 207182 56615 211666 66447 14859 14629 76263 14863 14598 14873 14854 69065 75475 13885 14872 54486 23887 68252 66054 58810 14862 14630 14865 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 96%9956529 ASL variants cause argininosuccinate aciduria 109900 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73864 RNA Polymerase I Transcription 216848 232440 319149 667501 107932 21429 20019 15077 21340 17191 21339 21341 64424 22130 13871 75316 66420 70333 69833 66136 245841 20017 19646 234366 26417 14885 209357 66467 66671 17749 245688 100043714 17420 12572 13872 23894 14884 23942 17192 15267 319168 319167 229542 319186 319178 319183 19285 319182 319190 319955 106298 110147 319176 21374 319181 116871 116870 20018 14534 20016 319169 18519 12417 625328 78303 319188 15270 433759 15182 624153 382522 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly 109006 18971 237911 269400 13871 78797 26426 68523 72199 26425 26371 67563 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions 244373 67384 14182 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation 14172 80857 14180 14184 80903 64654 14175 14173 14164 GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation 242425 14702 14696 14680 16519 16520 104110 54393 14697 14678 16518 14677 16516 14679 14710 432530 14699 210044 66066 104111 14700 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 224129 11512 14693 11513 11514 16517 64337 11515 14709 14701 242851 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%8868773 rRNA processing in the nucleus and cytosol 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 55989 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 66362 67248 109075 100040331 66583 67941 27998 72544 50911 69639 72662 66446 227715 57294 104318 56200 72515 67676 27993 102614 50912 67619 66878 217109 110816 68327 66138 229504 208144 98956 67276 67973 18114 18572 78394 53414 216156 269470 59028 12181 21771 110109 75273 215193 64934 217995 67674 73674 67755 68272 213895 76130 216987 66254 66249 353258 56095 71340 224823 102462 69072 213773 105372 67205 27373 72554 104662 67053 52705 230082 245474 223499 269536 80886 70683 100041622 97961 233802 24128 66164 66181 27966 57750 74035 100608 100040177 234374 68147 667035 30877 75416 57315 52530 14113 68979 208366 227522 14791 57316 67045 54364 72198 65961 622491 68533 67134 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 96%114604 GPVI-mediated activation cascade 74769 18762 11848 56212 56760 234779 320207 11852 19353 22324 20963 18710 19247 19354 14360 104709 22325 15170 106722 14127 243816 14726 57257 17096 16818 30955 18708 16822 18709 16797 18706 18607 INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 96%6783783 Interleukin-10 signaling 16451 16173 12519 12524 20303 20304 20293 20302 20297 16177 100039973 54721 16175 20299 16153 15945 14293 15894 19225 16193 330122 16181 16878 21857 14128 14825 21937 19204 21938 16178 16160 20848 16176 16159 16155 16154 21926 12985 12772 12768 12977 12774 12981 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%1222499 Latent infection - Other responses of Mtb to phagocytosis 17002 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 96%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 56637 667035 22190 18024 59029 67089 70247 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 96%76002 Platelet activation, signaling and aggregation 320207 11472 20779 11651 22324 18710 26416 12928 18754 18755 320127 76192 26413 18787 104418 26417 14360 239273 56077 12988 66082 20416 231871 22325 380921 16002 110524 109905 16000 269060 110197 217480 13139 331374 14723 57257 54519 17096 20662 22371 16416 110157 16784 14161 21894 215449 21825 109689 216869 30955 18708 18709 110135 99571 18706 22330 18607 74769 109711 54216 11806 56760 11852 21390 19354 14673 640703 268373 19156 14674 19419 15234 22041 11820 72017 57349 18762 11848 14675 14697 14710 14699 66066 14700 14708 14706 14672 14704 14695 14676 22145 14693 64337 14709 14682 14701 19246 14724 268936 192176 54368 14729 14702 14696 56212 234779 23945 70839 20963 14678 14677 232345 14679 11657 20909 14688 68117 21857 14083 21803 21808 21809 242851 12331 18643 16438 16439 18441 12491 16440 12527 56744 14064 14062 14061 14065 667310 385643 18752 14828 11551 19128 11552 13645 11553 16822 14456 16797 22065 18751 22068 106722 26946 14127 243816 14726 18753 18783 16399 14268 11818 27359 12258 21346 56508 223864 20716 227290 18591 117586 11674 109232 71946 12759 215789 235505 67988 12321 11537 18613 26968 68038 20912 20911 21922 20255 108101 218454 223601 12512 19353 12927 80718 16426 22138 227612 60595 104009 320202 70945 53612 67059 20703 19247 18761 11625 21767 19395 19073 56541 74145 14067 104709 12631 14205 21832 17480 15170 80884 20344 21859 74840 94175 13041 22631 20363 11747 16427 18815 56193 18816 19039 56055 13601 240334 14069 20692 22388 75396 16818 22341 18407 22339 22340 11804 18750 71660 67072 66866 27999 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1971475 Glycosaminoglycan-protein linkage region biosynthesis 76898 12111 121021 13004 15530 103978 218271 235534 14733 15529 11603 23888 20971 233781 217119 20969 14734 117592 67883 71951 20970 29873 215015 280645 13003 14735 72727 12032 13179 UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases 22632 15161 56436 75302 17463 68837 57296 22223 20422 50933 26445 14479 17425 26446 71599 19172 228790 19173 19175 56207 19177 26443 26444 19170 66413 667035 22190 11461 59029 67089 70247 104416 621893 319162 15267 319173 218214 319163 319168 17131 319167 12021 108155 319176 56456 56505 21812 21813 225280 56249 69714 227195 109275 68142 18002 233875 70020 235134 319169 21762 22123 19179 19181 21803 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 110962 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451307 Activation of Na-permeable kainate receptors 14806 14805 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 96%140179 Amine Oxidase reactions 17161 109731 212503 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants 13866 59079 12539 13649 18183 83961 100042150 12223 18176 14388 20662 13874 15461 15200 211323 18803 13645 18708 18706 20416 15519 CO-INHIBITION BY BTLA%REACTOME DATABASE ID RELEASE 96%9927353 Co-inhibition by BTLA 208154 15170 230979 19247 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9940465 ChAHP complex assembly 319178 319183 319182 232440 319190 319149 319169 240442 11538 12417 12412 319176 107932 319181 15077 15267 78303 319188 319168 15270 319167 624153 319186 382522 RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696273 RND1 GTPase cycle 13836 14252 232906 56374 381293 20867 12389 83669 18844 108670 12874 11855 232339 109620 14786 223881 208994 108686 19249 66922 227937 20257 67586 71228 68187 93840 11671 327826 229658 226525 77480 269608 107971 218581 17063 18708 19655 18709 53382 22042 380664 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 96%428890 Role of ABL in ROBO-SLIT signaling 12331 11350 19876 11352 20563 76707 76499 67252 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674404 Sorafenib-resistant PDGFR mutants 18595 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding 107338 15239 20404 75612 320634 20619 12874 117197 245638 27059 18457 224139 94245 80912 11777 170760 20615 21987 232946 20661 77929 67804 69178 68953 109689 11768 11769 11774 108012 11764 11765 11767 252903 233489 18704 22320 17113 14533 13423 20909 11840 66616 74325 15481 67489 20955 231580 11766 14325 11781 67602 108011 215890 74438 29816 105245 64138 13430 216705 11782 72685 108124 16004 14319 19345 67300 12757 22318 11820 22042 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 96%264870 Caspase-mediated cleavage of cytoskeletal proteins 14453 12367 11518 13169 18810 12368 227753 22352 12370 12369 20740 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis 20181 20182 268903 22259 18534 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p 207958 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 96%381119 Unfolded Protein Response (UPR) 270669 56494 12282 18044 13666 18045 12317 18046 20416 11910 56453 100037258 74126 14583 11518 21894 71853 20818 107513 68090 13665 78943 67204 77128 26427 22027 66362 208647 26905 109075 381801 66583 27362 27998 27053 72544 225849 12915 50911 320209 69639 78284 72662 64209 66446 22393 16905 227715 15191 74108 52639 72599 70640 13191 11911 192193 74322 12611 20293 71765 22642 28106 28146 75766 16006 231997 12751 56219 67398 228998 54616 12913 226641 52808 58193 105785 11370 11972 66515 69162 12608 13198 208677 606496 14828 67838 50907 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production 13479 58861 14598 319446 70086 23887 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry 54124 56436 20459 17463 17187 75660 57296 20422 26445 26446 12575 19172 19173 211586 19175 13555 19645 19177 21781 21402 12567 26443 12443 11651 26444 12566 11652 19170 12447 66413 26965 56371 667035 27401 22190 12448 59029 12576 19646 67089 70247 66671 17869 17420 12572 12428 13559 104394 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 19651 26441 63955 22390 26442 72568 69077 23797 66997 12530 231506 23997 12531 629959 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME%R-HSA-5619115.5 Disorders of transmembrane transporters 117591 15275 16514 114479 269523 20495 20497 107723 19386 20928 12638 244373 228368 24060 445007 11806 13521 235504 18174 74591 53945 27413 11416 27421 20521 19300 69912 54403 20538 238384 103988 26569 246787 103468 22232 23985 72027 13487 20525 74104 20501 104245 234865 12215 21762 20516 22123 15203 18670 68421 28253 59015 19179 170441 69736 19181 71279 11666 19182 317750 23996 12870 24059 19184 110379 26440 19166 20533 19167 26441 26442 69077 20505 66997 142681 23997 20531 19743 56436 17463 57296 20422 26445 11998 26446 19172 54140 19173 26361 19175 12000 63993 236794 19177 331004 26443 26444 19170 12780 66413 667035 22190 214111 59029 67089 70247 20927 231103 20537 20526 13162 18400 170762 108989 226144 231042 227699 223921 227720 269113 66679 18141 107939 193670 69482 54197 71805 229782 54563 56774 19069 70377 70699 30962 20532 216440 72787 18226 218210 11303 20520 74338 20510 102680 66753 20512 20540 67819 246049 17254 116891 20338 216227 67470 27409 27410 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 96%72165 U12 Dependent Splicing 319322 107686 384091 666609 68705 20641 98053 101943 20638 81898 66420 69833 67710 245841 69920 67332 20022 192159 20020 231329 20021 69241 17749 100043714 66055 67197 107701 68092 72047 433702 20624 27366 225027 67996 22608 68879 320632 66125 66585 74351 20382 110809 67797 76167 22184 50996 78372 67225 67178 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) 16527 223604 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins 246082 12458 654460 654465 244332 629114 12772 77674 24088 654464 21897 266620 654459 75400 246700 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME%R-HSA-5609975.6 Diseases associated with glycosylation precursor biosynthesis 14635 227697 68563 74246 67422 319625 110119 50798 57357 14430 54128 14583 13480 72157 13481 52014 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 96%9665250 Resistance of ERBB2 KD mutants to AEE788 13866 59079 12539 15519 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112122.3 ALKBH2 mediated reversal of alkylation damage 231642 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9702509 FLT3 mutants bind TKIs 14255 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181430 Norepinephrine Neurotransmitter Release Cycle 17161 233977 214084 20518 20517 19339 22318 20614 20979 68507 20907 327814 12889 22249 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 96%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 15529 11603 23888 20971 12111 121021 13004 20969 15530 14734 117592 103978 71951 29873 20970 13003 14735 14733 12032 13179 HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones 214899 30841 67014 319149 225876 277250 22289 338523 20591 18676 320595 20592 244694 71371 76804 15077 107817 218214 230674 104263 99982 75605 216850 193796 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 96%9918476 Assembly and Release of Dengue Virus Virions 22608 22088 18550 68137 107338 216705 17096 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling 13866 67268 67938 17904 11848 232906 11852 11853 17880 19877 17295 77579 19353 71960 20354 20130 16885 16886 223881 69632 17886 19878 213498 235611 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME%R-HSA-4717374.4 Defective DPM1 causes CDG-1e 13481 68563 13480 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 96%499943 Interconversion of nucleotide di- and triphosphates 67725 66422 320685 93692 18102 55936 18103 20133 20135 66588 78801 51797 21915 11636 11637 229949 635960 79059 56520 54369 382985 68870 14923 22171 50493 22166 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 96%5689877 Josephin domain DUBs 269523 19358 19359 667035 66124 22190 50873 110616 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis 67800 14626 14933 68393 215456 14245 64898 13350 64899 14732 233549 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III 53857 22152 227613 105513 22153 22142 22146 116733 67951 71955 73710 224640 319965 22145 50850 100042651 66371 545486 68953 238463 75608 22147 22151 208092 66700 22143 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose 13481 68563 13480 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 96%168181 Toll Like Receptor 7 8 (TLR7 8) Cascade 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 100561 11909 26419 12675 71398 27056 16476 18033 18035 18036 11820 81897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 170743 14281 170744 12370 22030 12475 67245 225471 106759 18034 54123 434174 66513 93765 66589 22034 66724 68652 20111 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium 12469 319757 12461 76260 319845 207911 12464 71769 52028 67378 93730 12465 102774 241950 71492 216363 72569 21454 12462 59030 20607 56297 PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.6 PI3K AKT activation 74769 16367 18211 11848 18049 18708 384783 18709 18706 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.5 Signaling by NOTCH1 18011 232232 13388 16449 240055 225164 12805 20602 11487 54485 207521 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 21885 15213 56233 17869 15214 21886 227325 13386 21888 15251 74198 14357 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 109689 216869 16396 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 18222 15205 19664 433759 15182 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357956 TNFR1-induced NF-kappa-B signaling pathway 22030 11796 11798 16150 71648 16151 14694 53376 71609 66513 26409 66724 68652 12675 21937 30941 22029 229603 22258 268749 106025 21926 74256 263876 21929 24105 19766 11797 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C 52717 56436 99152 17463 668450 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 56371 667035 22190 59029 67089 70247 21762 22123 19179 19181 19182 217232 23996 56317 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 96%162588 Budding and maturation of HIV virion 73711 22088 67123 330192 268373 76959 66201 20479 66914 66371 68953 105513 83814 75608 18571 667035 22190 107305 72543 208092 194309 66700 52348 116733 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer 236511 19645 21402 56438 16364 20850 12047 16477 18148 217351 26965 214150 26413 26417 15170 13433 17454 12608 14939 20848 16154 667739 433759 14235 22160 18646 54167 232679 22637 76850 239528 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism 230718 268782 50773 103850 22271 23959 64705 76654 72962 99586 103149 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-HSA-428930.4 Thromboxane signalling through TP receptor 14708 14672 14706 14702 14704 14696 14695 14674 14676 14675 14693 64337 14709 14697 14682 14701 14710 14699 66066 21390 14700 227290 14688 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%381042 PERK regulates gene expression 72544 50911 69639 72662 64209 66446 227715 74108 70640 18044 13666 11911 18045 18046 20293 12611 16006 226641 11910 12608 13198 14828 13665 67204 66362 26905 109075 66583 27998 27053 RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway 20148 19378 237320 13082 98711 12903 56847 19682 11668 242285 105014 232174 216454 546726 17252 11522 108841 26876 241452 105349 28200 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling 15461 15200 211323 18183 83961 100042150 12223 18176 20662 13874 20416 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%2161517 Abacavir transmembrane transport 20518 20517 26357 20519 18671 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 29813 59092 13496 12428 12575 12427 13555 22059 12566 108961 12447 12448 12576 52679 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 96%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 20750 12293 16412 15530 12295 12296 12297 16410 11651 16416 14609 16402 18439 81904 55991 58226 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%2029485 Role of phospholipids in phagocytosis 74769 246256 14131 18806 104759 16440 18753 234779 12502 53357 20963 18803 18754 381925 18805 18708 18807 18709 71910 229709 16438 14129 16439 18706 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 96%3304347 Loss of Function of SMAD4 in Cancer 17126 17127 17128 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%937042 IRAK2 mediated activation of TAK1 complex 68652 667035 22190 66513 26409 22034 108960 66724 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 96%2995383 Initiation of Nuclear Envelope (NE) Reformation 23825 16211 12534 98386 22367 64383 224640 13726 12442 71978 71782 19052 51792 16906 380664 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 96%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 224105 78514 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 96%114452 Activation of BH3-only proteins 209456 56455 211586 13555 22628 21781 11651 11652 22061 22062 12122 19057 171543 100039786 26419 54401 22631 55948 12015 22059 22629 19058 68097 21981 12043 22627 12125 23797 SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702624 sorafenib-resistant FLT3 mutants 14255 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 96%9032500 Activated NTRK2 signals through FYN 19353 18212 208869 20779 12064 14812 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-HSA-392451.5 G beta:gamma signalling through PI3Kgamma 104709 14708 14702 14706 11848 14704 14696 14695 320207 14693 64337 14709 11651 11652 14697 14701 14710 30955 14699 66066 14700 23797 14688 18607 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling 16451 16195 68981 16153 12330 56044 53379 98758 16160 16159 215449 667618 224105 16452 15978 66902 18453 54721 19188 11840 50931 12631 20955 50926 667310 66162 18569 12798 18738 268373 50498 12931 11632 20849 209590 12340 18826 17319 18788 12306 16162 20846 16161 246779 20848 15526 20656 21351 14873 21454 16906 17698 12346 DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 96%5609976 Defective GALK1 causes GALCT2 14635 AGGREPHAGY%REACTOME DATABASE ID RELEASE 96%9646399 Aggrephagy 234663 56455 235661 21821 12638 68146 26369 68097 57320 269523 15185 667035 13427 22190 93765 50873 13426 66589 13424 18541 15499 15519 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190370.4 FGFR1b ligand binding and activation 21814 67903 67112 14174 14165 14173 14164 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 96%912526 Interleukin receptor SHC signaling 14389 74769 18707 16451 16453 18710 16186 16331 16332 16184 20416 16183 15170 20662 16188 16185 12984 12982 16192 16191 12981 18708 18709 16452 18706 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism 14873 68214 109754 20525 109672 54338 20522 20527 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 96%913709 O-linked glycosylation of mucins 71685 26887 14426 20448 108148 171212 232984 353328 108105 241391 207839 72297 233733 94192 108150 212996 97440 654821 72077 271786 14537 67909 227327 53625 56336 56386 14425 269328 231727 230145 17829 14423 100039649 140474 224116 20446 17063 20444 59048 20442 20443 272411 231050 78754 20440 333424 210004 108760 73732 20447 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-HSA-8949215.3 Mitochondrial calcium ion transport 78506 215999 11640 69029 234847 73078 110893 69597 66865 381038 66815 170756 68115 68514 12034 22334 66592 18673 22333 27377 216001 56384 22335 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 96%1483248 Synthesis of PIPs at the ER membrane 83493 77980 67073 224020 77116 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 96%111452 Activation and oligomerization of BAK protein 12122 12018 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors 15505 12282 12317 380713 238055 15519 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a 14423 20448 20446 20444 20442 20443 20440 20447 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME DATABASE ID RELEASE 96%5339562 Uptake and actions of bacterial toxins 26400 26398 15200 18550 15519 640703 14917 170761 26395 26396 12527 56216 20980 64176 50493 18571 22317 64051 22318 20614 20979 20907 75209 13629 15516 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 96%139853 Elevation of cytosolic Ca2+ levels 269717 18438 26946 16440 109305 18436 228139 18440 94045 231602 18439 22065 22068 20866 16438 16439 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 56187 17988 19352 209456 22059 11799 12662 22061 66813 22062 21981 64058 12053 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 96%9012546 Interleukin-18 signaling 16189 16163 16173 16174 16182 11689 16068 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943965 CHD3, CHD4, CHD5 subfamily 216848 14377 232440 319149 240442 13445 11538 269610 12412 106795 107932 22780 22779 78266 228880 15077 52004 17191 233410 11819 22778 622675 70998 14121 19646 234366 245688 22196 23942 17192 15267 70802 101631 319168 73503 319167 229542 319186 319178 319183 319182 319190 319176 319181 116871 22026 116870 319169 12417 625328 78303 319188 15270 433759 15182 624153 18534 382522 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins 216848 319178 319183 319182 232440 319190 319149 319176 107932 319181 15077 243834 232854 432769 21408 19646 234366 116871 12419 116870 21849 245688 319169 22196 54343 100043429 237758 23942 17192 625328 78303 15267 319188 15270 433759 319168 233060 431706 319167 244713 15182 624153 84505 229542 434178 319186 382522 INTERLEUKIN-7 SIGNALING%REACTOME%R-HSA-1266695.10 Interleukin-7 signaling 16367 16451 319149 20586 16453 20851 20850 15077 18710 16186 15234 20848 16197 216233 12700 93871 19373 19374 18708 384783 53603 12703 18709 16196 57914 KIDNEY DEVELOPMENT%REACTOME%R-HSA-9830369.1 Kidney development 16371 17300 13388 14573 16449 20472 279653 21410 20563 14234 12387 12159 15431 268902 15412 16869 18504 241226 18993 15396 14462 67701 114249 14173 13797 109663 22431 15403 15904 14585 23892 231507 18510 22412 16372 20471 22411 19713 16412 16848 22417 14013 15378 14048 58198 23967 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 208643 230594 214290 208718 218693 13682 192170 13681 75705 54196 18458 13684 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 96%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 224105 26441 26442 69077 66997 23997 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate 16922 26458 56794 111175 20524 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME%R-HSA-168275.6 Entry of Influenza Virion into Host Cell via Endocytosis 67300 12757 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956553 OTC main chain variants cause OTC deficiency 18416 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 96%1489509 DAG and IP3 signaling 12326 19088 55984 19108 19087 19084 104110 12322 12323 108058 12325 18754 432530 210044 104111 229709 16438 16439 18747 100039592 640703 224129 16440 18753 11512 11513 110355 11514 18575 11515 18574 18573 18749 207565 18752 18803 18750 19085 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME%R-HSA-5579026.4 Defective CYP11A1 causes AICSR 14149 14148 13070 68165 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%8849472 PTK6 Down-Regulation 20459 19246 20811 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 96%1630316 Glycosaminoglycan metabolism 11881 18295 15931 76898 12111 121021 212898 13004 244757 114332 72297 14595 17022 78752 75612 192188 60322 269941 108902 218271 14264 545291 70484 27416 23908 15529 23888 20971 20969 54613 56398 15587 15442 50917 71951 20970 54371 71797 14735 12505 268512 231583 14043 14042 15531 15530 13521 27419 73836 56336 56386 103978 235504 74241 54616 58193 80982 14733 53374 83398 50786 77590 108652 93683 231727 14734 116847 319901 64580 117592 67883 59031 57370 53418 56375 215015 50787 15366 15118 15117 15116 72136 20544 58250 54710 628779 235534 50785 74468 11603 16545 233781 217119 227327 53625 15476 15478 27029 195646 17423 280645 56773 72727 234356 27047 29873 13003 338362 110006 76969 77042 15586 328779 20444 109685 23971 20442 70893 23972 20443 15212 319415 15211 78923 12032 13179 15932 12091 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 96%9005895 Pervasive developmental disorders 18747 81004 640703 20602 433759 12326 21372 56310 15183 20185 20466 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol 72554 52705 230082 245474 223499 70683 100041622 233802 55989 66181 27966 100608 100040177 234374 68147 75416 57315 52530 14113 68979 14791 65961 622491 20115 76846 67134 72515 27993 217109 110816 68327 66138 208144 98956 67973 20044 18572 667279 78394 269470 59028 21771 110109 215193 217995 67674 73674 67755 213895 667739 216987 66254 66249 224823 102462 213773 105372 67205 DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME%R-HSA-9853846.1 Defective ANO6 does not expose PS, PE on the platelet membrane 105722 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 17913 69940 22628 11651 66482 11652 20619 17886 56044 16568 100039786 53869 54401 55948 108099 20912 241113 17918 16579 17274 19353 53413 20909 20336 240028 68938 228850 19325 107371 68328 57915 20528 210789 640703 68365 74741 16569 22631 22629 108079 19079 105504 108097 19341 211446 102058 22318 22627 19082 TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 96%9839394 TGFBR3 expression 328572 233833 236511 20683 21423 213988 217351 214150 21406 20181 21413 17877 17454 17878 17927 17928 15201 17127 17128 18109 21814 118445 19401 76850 239528 GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70370 Galactose catabolism 14635 74246 319625 14430 72157 11677 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 96%3359469 Defective MTR causes HMAG 210009 238505 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 96%433692 Proton-coupled monocarboxylate transport 57274 80879 20501 20503 13723 12215 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 96%1433617 Regulation of signaling by NODAL 269275 11479 11480 320202 620395 11481 23863 12622 18119 13590 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 96%1483196 PI and PC transport between ER and Golgi membranes 56305 LIPOPHAGY%REACTOME%R-HSA-9613354.4 Lipophagy 108097 108099 66905 19082 241113 108079 15481 11520 19079 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME DATABASE ID RELEASE 96%9637687 Suppression of phagosomal maturation 16211 233405 271457 667035 22190 12721 19349 18126 16646 15239 108664 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 96%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 20848 18999 99377 22773 100038891 13835 15221 620395 20674 58198 14173 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation 11771 11772 71770 232910 11773 16818 11840 108664 12504 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants 11682 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 96%2559582 Senescence-Associated Secretory Phenotype (SASP) 52717 99152 668450 232440 12575 319149 19697 12571 12567 12566 15077 56371 667035 22190 12576 26413 26417 110651 20112 77683 15267 319168 29817 319167 14281 319186 319178 319183 319182 12428 319190 110147 319176 319181 16175 23939 100043858 12580 12579 12578 16193 20111 319169 12427 12608 20848 217232 56317 625328 59008 16476 78303 18033 319188 66156 15270 216080 69957 17222 75430 68612 52563 624153 22194 68999 52206 100039535 382522 DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-HSA-8932504.1 DAG1 core M2 glycosylations 13138 217734 68273 268510 99011 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181429 Serotonin Neurotransmitter Release Cycle 233977 214084 27204 19339 22318 20965 20614 20964 20979 68507 20907 327814 12889 22249 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 96%5696394 DNA Damage Recognition in GG-NER 22632 26891 26754 56438 56456 26370 11545 56505 667035 225280 22190 26893 11461 56249 69714 227195 109275 26894 68142 11546 108679 233875 70020 19358 19359 235134 22591 107986 26572 26895 12848 99375 72584 100043806 13194 RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 96%5625740 RHO GTPases activate PKNs 12532 232440 11848 319149 22628 77579 76804 71960 15077 17886 67268 100039786 54401 11835 55948 263803 15267 319168 319167 18479 319186 18607 319178 319183 319182 67938 17904 319190 11852 17880 319176 319181 19353 17978 320795 109333 19046 99982 319169 22631 11853 22629 625328 78303 319188 15270 22627 329251 68458 17931 624153 382522 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD 12040 243382 13171 13382 12039 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 96%3371453 Regulation of HSF1-mediated heat shock response 193740 26413 26417 15499 72630 56354 50497 12017 81489 70356 67669 219158 19386 29810 18415 110920 67384 66538 70369 23950 15525 15505 17164 22791 73442 170762 108989 231042 227699 223921 227720 445007 269113 15512 66679 15482 18141 213539 107939 69482 71805 54563 19069 70699 72787 11920 18226 218210 56637 69912 93759 15481 68275 103468 68240 19891 234865 59015 69736 15526 110379 14828 22627 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%449836 Other interleukin signaling 19152 12986 19283 242700 16451 20969 20911 12504 12367 54721 16155 12985 22318 20614 12977 12978 20907 16170 20909 20908 76527 109658 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 96%9610379 HCMV Late Events 319149 15077 107305 72543 27681 70160 194309 52348 116733 73711 22088 67123 330192 28084 19386 66914 66371 68953 621893 75608 234852 319162 15267 319173 319163 15387 319168 319167 170762 108989 231042 227699 208092 223921 227720 66700 445007 269113 319186 66679 18141 319178 319183 107939 319182 69482 12609 71805 319190 54563 19069 70699 319176 72787 319181 18226 218210 105513 69912 103468 319169 234865 59015 69736 78303 319188 110379 319189 382522 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70921 Histidine catabolism 76507 71761 107239 15186 15109 243537 140483 67383 14317 EICOSANOIDS%REACTOME DATABASE ID RELEASE 96%211979 Eicosanoids 320997 13120 106648 631304 100040843 13118 72054 208285 64385 21391 19223 13124 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER 68275 106344 72151 18971 68240 18972 59001 22594 19891 16882 18973 18974 19687 19718 69263 67967 66979 667035 16881 22190 27015 69745 18538 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%196108 Pregnenolone biosynthesis 100042622 14149 76205 14148 59045 12257 170459 20845 13070 11677 68165 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport 56436 17463 57296 20422 26445 26446 19172 19173 19175 17250 19177 16514 26443 26444 12780 19170 269523 66413 74610 667035 56199 22190 56325 224814 19299 59029 27403 27416 11305 67089 239273 224742 11304 70247 76184 77706 217262 192663 217265 27404 56535 26874 20928 12638 244373 19298 13665 67204 226144 26905 76408 193670 54197 11806 11307 70377 216440 18671 74591 27421 66753 67819 116891 20338 74104 21762 22123 18670 67470 19179 27409 19181 11666 27410 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451306 Ionotropic activity of kainate receptors 110637 640703 14807 14806 13385 14805 52589 53310 13383 14809 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 12447 12448 19645 12566 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 96%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) 20510 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 96%216083 Integrin cell surface interactions 20750 16456 320910 12550 16420 241226 17022 15896 109700 16398 16400 16403 12817 16404 11603 213119 107581 16408 16412 15898 12829 381924 12828 16407 12827 16409 12826 319480 22329 16421 21923 83964 12822 16423 16411 16399 14268 16416 12841 16414 78369 16401 67374 16402 14161 12840 15891 12845 21825 14118 22370 237759 12505 12839 110135 99571 18613 15530 16419 15894 12215 16410 16542 104099 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis 20602 23989 12567 59024 11450 327987 12445 11819 70625 68975 19646 234366 234959 94112 28077 70208 12491 245688 171285 17125 17128 23942 17192 56771 80509 67224 19014 229003 66999 16600 328572 12609 21372 109151 17977 19017 17978 59035 81004 66993 69790 26896 15183 20185 12914 20528 56406 108098 12608 18033 66172 170826 192191 78334 216848 12865 20933 19697 107932 20788 75613 381379 22410 12224 12606 20181 67219 19013 19016 21926 68910 13591 16846 18139 264064 13654 67544 230753 229542 76199 67279 57875 16956 70673 103968 22227 12683 12686 94187 116871 12162 17979 51810 216154 116870 22408 13592 51813 11770 69792 21803 67381 433759 15182 18534 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-HSA-6803211.2 TP53 Regulates Transcription of Death Receptors and Ligands 22062 209456 21981 21933 22059 16009 68742 14102 22061 DISEASES OF GLYCOSYLATION%REACTOME%R-HSA-3781865.4 Diseases of glycosylation 66548 18295 13138 330267 207596 12111 224697 121021 227619 56229 13004 353328 239337 68273 77794 14595 94192 279028 17022 269941 108902 218271 14264 15529 23888 20971 14635 227697 74246 319625 20969 19025 50798 57357 14430 14583 13480 13481 71951 20970 207958 21825 14735 52014 66789 14043 68563 14042 67422 18010 15530 13521 103978 14733 53374 14734 116847 117592 18129 18131 18128 18132 72136 11603 16545 72157 56773 72727 27047 56737 320438 208624 102580 24070 208211 381903 13478 328370 108153 23794 30806 108154 16795 210417 271127 229595 208936 77739 381694 269959 14425 269328 230145 100689 110119 233744 235130 240322 20357 57377 54128 16848 11504 20356 17829 18636 100039649 21826 140474 29873 217664 224116 13003 226866 217734 17063 59048 240913 23972 223838 15212 99011 15211 237360 12032 330119 13179 216725 73732 12091 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias 16514 20927 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome 11881 FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm 12387 13813 12767 21416 12550 20671 20997 14836 15376 27217 14465 17126 17127 17128 14463 SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections 71164 53618 16451 20448 56208 227619 66383 19089 67443 13200 208884 58194 78610 22628 12389 11651 11652 22324 269523 18566 19646 234366 245688 100042069 54401 23917 55948 20662 19877 233870 23942 19878 378425 218978 16452 218035 15516 18607 328572 66357 22154 269338 16172 18550 69550 18024 22365 66101 19035 80743 12914 28185 268373 71586 230073 66641 71956 14225 18521 228607 217069 12695 20817 224912 20815 56217 77573 14609 22627 24088 21897 93687 216848 257630 56480 20683 54131 66397 58203 171095 56438 107932 69608 15006 218811 99683 240095 18148 667803 23881 27041 14991 77371 100039786 20334 19712 16412 20390 15382 66371 68953 75608 12362 12785 228545 170762 108989 16396 231042 208092 227699 223921 229542 66700 227720 19766 269113 67197 66679 56532 18141 107939 69482 71805 73158 54563 71732 234779 53902 19069 70699 72787 16453 18226 16177 218210 105513 11771 54721 11772 20963 50724 60406 71770 13609 233405 12229 20847 64685 15980 17060 15979 58799 12518 228005 99982 217864 14228 15985 27207 15975 67097 94246 670832 18391 100041953 633683 13207 110606 16171 20044 26554 71954 27050 107392 667279 14272 20085 232910 238247 668144 11773 15353 20084 382492 20055 75617 100043508 27370 629957 20102 20103 668668 667739 66481 225058 100038875 11931 58861 17973 16785 11932 11933 66824 216799 18186 19645 56188 100038882 12330 15519 15529 100039316 11928 23888 98660 20971 16211 232975 100039592 57780 19386 20969 59095 108017 20115 17127 17128 76846 100040298 17192 71951 20970 14735 267019 445007 67941 57294 15530 50528 70008 171283 103978 14733 69912 103468 15977 14734 234865 12675 59015 69736 18033 110379 12846 18035 12048 75669 81897 225326 107686 19697 384091 666609 216766 16150 621705 21872 20595 16151 66603 53975 192656 276919 20641 16179 667035 20638 225913 22190 69731 432803 26409 16194 67332 67089 257632 11603 107607 101772 14815 108960 22196 16401 102566 404545 170743 15007 12010 170744 105722 382014 17195 320091 22031 56489 233246 20014 72512 54123 57261 103963 243634 56637 66513 69038 93765 66589 13135 19247 22034 116871 66724 116870 68652 15170 50868 15469 22631 103534 67075 57377 22629 27801 228136 20846 75965 70546 108687 14423 269181 214424 57437 328417 217664 606496 69035 67287 433759 107895 80285 20446 52552 20444 671535 22346 20442 547253 80286 20443 17308 17158 15182 68292 20440 23797 67569 16430 14376 20447 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%193993 Mineralocorticoid biosynthesis 12640 13072 15492 15497 16866 13079 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 96%9031525 LXRs regulate gene expression to limit cholesterol uptake 22260 20181 20182 218203 22259 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 96%181431 Acetylcholine binding and downstream events 11438 110834 11449 110902 11435 11448 11447 11440 108015 108043 11444 110835 231252 SARS-COV-1-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9692914 SARS-CoV-1-host interactions 16785 56480 20683 54131 66824 216799 22628 19697 12389 18148 667035 225913 22190 67089 100039316 16211 100039786 100039592 20390 54401 15382 55948 20115 17127 108960 17128 76846 22196 100040298 12362 170743 16396 267019 67941 18607 56532 328572 57294 22031 56489 53902 72512 64685 69550 66101 19035 228005 22034 27207 67097 670832 633683 28185 20044 27050 667279 268373 20085 668144 20084 382492 20055 22631 71586 75617 230073 27370 22629 66641 18521 14225 629957 228607 20102 217069 20103 56217 668668 667739 18033 18035 22627 66481 225058 100038875 12048 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 96%392170 ADP signalling through P2Y purinoceptor 12 14708 14706 14702 14704 14696 14695 14693 70839 64337 14709 14697 14678 14677 14701 14679 14710 14699 66066 14700 242851 14688 RRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72312 rRNA processing 66362 109075 66583 27998 72544 50911 69639 72662 66446 227715 104318 110109 27373 24128 67134 27207 67097 670832 633683 20044 27050 667279 20085 668144 68626 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 55989 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 56200 72515 67676 27993 102614 50912 67619 66878 217109 110816 68327 66138 229504 208144 98956 67276 67973 18114 18572 78394 53414 216156 269470 59028 12181 21771 75273 215193 64934 217995 67674 73674 67755 68272 213895 76130 216987 66254 66249 353258 56095 71340 224823 102462 69072 213773 105372 67205 72554 104662 67053 52705 230082 245474 223499 269536 80886 70683 100041622 97961 233802 66164 66181 27966 57750 74035 100608 100040177 234374 68147 667035 30877 75416 57315 52530 14113 68979 208366 227522 14791 57316 67045 54364 72198 65961 622491 68533 72181 52575 75619 227682 83485 94254 224481 66132 66410 67390 217038 15108 69821 71989 101122 68017 GSD IV%REACTOME DATABASE ID RELEASE 96%3878781 GSD IV 232493 74185 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9638630 Attachment of bacteria to epithelial cells 109637 17075 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME DATABASE ID RELEASE 96%9909620 Regulation of PD-L1(CD274) translation 233833 213988 60533 236511 217351 17454 214150 76850 239528 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669935 Signaling by juxtamembrane domain KIT mutants 16590 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) 20779 11651 14061 12927 20963 12928 19395 12988 20416 21832 109905 17480 19419 14723 54519 20662 22371 16399 14083 14268 16416 14161 21894 215449 19246 11551 11552 56508 11553 223864 14724 110135 54368 99571 14729 18607 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R 15461 16002 16000 16001 18176 20662 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%2682334 EPH-Ephrin signaling 11848 11487 216963 14810 22612 77579 71960 16885 16886 17886 11461 14360 15529 22325 67268 545156 16443 57257 17096 19877 19164 19165 15461 100042305 208117 11465 59287 100039623 19878 224105 18479 110596 13836 67938 17904 17395 18481 17880 76709 19353 73178 53378 11771 11772 71770 56443 53972 74325 68089 67771 13848 54126 12631 11867 13846 13845 56378 270190 13842 66713 13840 232910 74117 17390 11773 13841 13839 13838 13837 13637 13636 14812 13643 13642 218397 21844 14083 13641 13640 13639 13844 13638 17974 67300 13429 13835 12757 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME%R-HSA-9845323.1 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 216848 232440 319149 67155 20586 20588 20587 107932 70127 29861 269397 15077 19708 268996 12055 12054 11461 77045 19646 234366 330890 13435 245688 23942 68094 17192 83796 83797 15267 57376 319168 319167 229542 319186 319178 319183 319182 319190 239985 319176 56456 319181 66993 116871 116870 93760 319169 625328 54427 78303 100039610 319188 622480 15270 433759 15182 624153 382522 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH 233833 232440 12805 20602 11937 11938 319149 14595 211586 53313 13555 66894 21781 79221 11651 12443 270118 15077 13557 15213 56233 17869 50721 15214 13649 13710 54613 15251 17127 76580 109689 216869 103806 328572 21372 333639 81004 18550 15183 20185 12914 22608 14534 21762 22123 19179 19181 19182 23996 19184 19664 16476 26440 19166 19167 13645 19346 26441 26442 69077 66997 23997 18011 56436 13388 232232 17463 16449 57296 240055 20422 225164 26445 11487 26446 54485 19172 207521 11491 19173 16450 19175 18129 18131 19177 18128 21402 18132 56438 26443 26444 19170 18759 170787 66413 26965 667035 22190 59029 67089 70247 21885 21886 227325 22059 13386 21888 14128 74198 208727 14357 19164 14939 19165 15208 100042305 208117 15267 59287 100039623 319168 56198 319167 264064 16396 76850 239528 319186 319178 319183 319182 236511 319190 18514 218977 67784 319176 19208 211652 21335 50701 319181 213988 217351 15185 214150 70315 15184 12140 51813 17454 20338 319169 22631 18519 16848 18222 15205 20846 625328 78303 319188 15270 433759 17242 14257 19719 20443 17305 224143 624153 140484 15182 100042343 382522 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis 18053 11848 192662 109904 18049 17136 68585 18377 235402 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME DATABASE ID RELEASE 96%5579022 Defective GGT1 causes GLUTH 14598 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 96%5657562 Essential fructosuria 16548 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 15107 97212 231086 11409 93747 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) 20501 12215 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) 21990 56437 14066 17095 12570 20393 15902 15901 23938 17172 54152 20408 15903 14283 211770 16478 17936 17937 20404 11838 13656 13655 381677 107746 103967 109880 12929 26416 12928 56044 64143 18049 216148 26413 26417 29857 20416 327826 18211 109905 77480 19094 20418 102626 19730 54401 73699 26415 26395 26396 19762 110651 18176 20112 20662 19769 15461 17164 19052 19053 51792 18708 18709 18706 328572 74769 21770 13712 15904 16477 17260 17261 23939 11909 13430 18212 18803 12569 12568 384783 16367 11848 73086 107932 17258 11540 21406 19712 11516 11517 100040260 101568 235584 67603 319520 72349 14281 13654 20807 14282 13653 11771 11772 71770 20111 232910 11773 20848 67300 13429 12757 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation 50933 19823 71599 330369 269523 24108 102323 54638 50788 140858 100737 73828 66199 56468 230796 415115 80913 213464 27784 114893 54607 99311 71991 28199 230903 74106 66772 78309 208372 76863 76454 245688 240263 66498 52245 98193 65247 434130 17846 65255 15251 320808 79043 66200 67731 14155 53417 142687 76501 242418 78910 69456 59043 65256 12848 14154 70392 216233 12238 12700 68842 66398 75763 233805 234664 225055 74251 232539 100043806 26891 231670 69754 77113 12702 207952 320118 30843 68854 76294 72323 399566 18024 214931 18002 67923 106052 242960 30838 71902 30050 50762 56438 50754 71833 213980 68628 50789 217365 30839 22230 26554 211255 71745 99375 72584 13194 76843 12575 66105 27401 11799 75221 18412 68350 26893 224111 26894 108679 107986 26572 21762 22123 26895 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 223499 19172 19173 19175 72345 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 67089 103583 70247 117589 78541 69299 233902 50760 235320 242521 209239 74492 72194 69706 217194 226541 65257 242785 26374 211949 26754 233040 231672 231863 101358 12449 224023 12189 71538 67455 14794 100041766 217217 71999 269529 83962 230654 635668 13819 66515 269514 78889 68431 230904 71865 380928 50868 233826 207215 22200 627648 75717 67921 22192 142688 243574 74646 216080 448987 22346 228003 212919 71393 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%110362 POLB-Dependent Long Patch Base Excision Repair 11545 18970 14156 11792 16881 26430 100206 11546 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576892 Phase 0 - rapid depolarisation 14169 235281 14168 14167 14166 20266 20265 56808 12295 12296 20271 399548 20272 20274 12322 20273 12323 108058 110876 12325 20269 81904 72821 110880 20264 640703 54377 24046 81905 54378 12288 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME%R-HSA-4570464.4 SUMOylation of RNA binding proteins 18141 107939 19763 69482 71805 54383 54563 13619 19069 70699 55989 241915 72787 12416 18226 218210 19821 69912 103468 19386 234865 30951 59015 15381 22196 12418 69736 100043429 110379 15387 170762 108989 231042 227699 223921 227720 445007 269113 12151 66679 22658 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia 67470 27409 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%1170546 Prolactin receptor signaling 12234 20850 14600 19116 26965 19247 21402 56438 16452 19109 20851 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes 14381 12914 328572 21351 17134 21881 18024 110208 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells 246086 19213 21410 18096 18609 15379 14165 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 96%69239 Synthesis of DNA 52717 99152 668450 12566 12447 56371 27401 16881 12448 12428 109145 17216 272551 17215 17217 17218 17219 17220 78833 12544 69270 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 56436 17463 67177 57296 23834 20422 26445 14156 26446 57441 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18969 18968 19075 19076 69745 327762 59001 19687 19718 69263 66979 50793 18392 18393 66634 26428 26429 56452 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 67967 217232 56317 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%977068 Termination of O-glycan biosynthesis 20448 269328 353328 17829 100039649 140474 224116 20446 17063 20444 20442 20443 20440 73732 20447 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination 70408 20018 69870 70428 18027 17749 218832 18029 100043714 67005 20823 20016 18032 12909 67065 74414 66420 69833 78929 245841 26939 67486 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 96%140342 Apoptosis induced DNA fragmentation 16211 80838 13368 13347 16646 97165 12367 434174 56702 50709 14957 50708 14958 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5685938 HDR through Single Strand Annealing (SSA) 12021 81601 327762 19361 22427 19718 69263 15574 11920 12189 235610 231724 237911 19355 16881 225182 26909 235559 12144 13870 68275 11350 106344 72151 19365 68240 19891 50505 19367 19356 19360 17535 21975 27354 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 96%416550 Sema4D mediated inhibition of cell attachment and migration 19353 20354 20130 11848 223881 232906 17295 235611 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654733 Negative regulation of FGFR4 signaling 14172 80857 14170 14180 12402 14177 24064 64654 17346 14175 14173 14164 83379 109880 667035 22190 19247 26413 26417 327826 19052 19053 51792 80903 14186 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 12448 12577 12576 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription 75660 67177 12534 23834 211586 13555 21781 67141 12544 18392 12447 20135 19646 18538 50496 13559 104394 18968 12427 22171 21877 13361 433759 19650 19651 72568 231506 629959 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation 20733 20732 15451 54426 15234 17295 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9823739 Formation of the anterior neural plate 14472 18999 18508 24136 225207 100038891 18991 18424 20664 20674 22772 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%73884 Base Excision Repair 232440 14156 17193 234258 71726 11545 382913 18294 72774 16881 18207 28113 15267 101185 319168 319167 69745 26430 100206 319186 319178 319183 319182 18970 59001 11792 319190 22594 16882 57321 19687 19718 319176 69263 319181 59047 66979 319152 21749 497652 21750 18538 11546 68275 106344 72151 18971 68240 18972 19891 319169 18973 18974 268395 67967 78303 319188 15270 624153 382522 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 96%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 18295 16545 14264 116847 17022 27047 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates 12021 224008 60530 81601 327762 20422 19361 114714 209334 22427 11920 12189 12190 237911 57434 225182 74335 26909 71711 12144 381306 233826 19362 268465 52864 19360 17535 21975 19363 19364 27354 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids 320997 13087 13120 13107 631304 13118 72054 208285 13088 64385 56448 11529 13110 106648 100040843 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function 14539 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels 240444 238076 225030 16535 16538 16539 16497 60613 16512 98741 66733 380728 240595 16490 16491 226922 16492 192775 16485 170738 16506 16504 99738 16493 16494 16498 16495 242151 16500 16502 268345 16508 56543 382571 241794 16510 211468 16511 16499 67498 16536 238271 110862 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME%R-HSA-9955542.1 CPS1 variants cause CPS1 deficiency 227231 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME DATABASE ID RELEASE 96%9818032 NFE2L2 regulating MDR associated enzymes 76408 12914 328572 27407 26357 18024 17250 17135 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly 70572 15519 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 109905 20779 54519 20662 22371 14083 16399 14268 16416 14161 21894 215449 110135 99571 INTERLEUKIN-9 SIGNALING%REACTOME%R-HSA-8985947.8 Interleukin-9 signaling 16198 20850 20848 16199 16451 16186 20846 16453 20851 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia 14377 DEPURINATION%REACTOME DATABASE ID RELEASE 96%73927 Depurination 319178 319183 319182 232440 319190 57321 319176 319181 234258 319152 18294 21749 497652 21750 319169 268395 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 96%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 12534 18817 59125 12442 59126 217718 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 96%68689 CDC6 association with the ORC:origin complex 50793 18392 23834 18393 66634 26428 26429 56452 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 96%72200 mRNA Editing: C to U Conversion 11810 80287 11811 69865 71281 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655302 Signaling by FGFR1 in disease 14389 80857 110279 14180 14177 64654 14175 14173 20851 14164 20850 75296 360013 432508 67529 13047 76007 14182 327826 67384 18176 14388 20846 20662 20848 244373 15461 18803 21848 18708 18706 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 96%9793528 Ciprofloxacin ADME 20517 26357 11657 19879 28250 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 96%156587 Amino Acid conjugation 435528 107146 233799 233801 272428 117147 SDK INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373756 SDK interactions 330222 237979 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism 14874 17436 18563 667035 22190 13382 22333 107029 27418 70456 74125 16833 226757 56705 76282 109801 16832 381511 68263 228026 18604 236900 27273 68477 75387 18004 66089 27402 68636 106557 18597 18598 382051 319518 16828 66771 55951 76425 59003 109264 235339 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%1307965 betaKlotho-mediated ligand binding 83379 14170 14186 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 96%112313 Neurotransmitter uptake and metabolism In glial cells 105727 20511 14645 20512 REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 96%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 56480 667035 22190 22031 56489 106759 21353 71648 142980 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-HSA-1834941.5 STING mediated induction of host immune responses 56480 446099 54131 207521 20821 19090 22040 72935 72512 20852 268857 22596 14375 214763 17535 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants 18595 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%5620916 VxPx cargo-targeting to cilium 107371 69940 53869 107338 18763 18764 17274 66482 105504 215445 216363 211446 53413 102058 13196 212541 233649 12789 11843 20336 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 96%2219530 Constitutive Signaling by Aberrant PI3K in Cancer 14389 77647 16367 18213 14172 80857 14170 14180 268980 14178 18183 14177 320207 83961 67112 20779 100042150 64654 14175 14174 17295 14173 14164 22324 83379 18710 13983 14255 14360 327826 13982 13649 21802 18595 30955 12478 18708 18709 18591 18706 74769 18707 12487 12519 12524 56212 12223 71920 13874 19353 15200 211323 14256 19247 19354 104709 13866 12064 14388 15234 18212 18205 78405 11839 16818 16590 13645 80903 384783 14186 14165 83490 18596 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT 14389 21682 16923 17395 17228 19273 71520 14159 14158 23921 12402 14783 22612 20851 19353 22324 20850 14786 18710 19247 14360 54607 15170 17096 18176 20846 20662 20848 15461 12649 17444 16590 16818 18750 18708 12703 18709 16452 18706 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints 52717 99152 29870 668450 12534 22628 70620 26416 240087 12545 19094 54401 55948 17216 17215 17217 17218 17219 103573 17220 12544 22627 22390 12530 27373 93687 208583 12532 23834 268930 56438 100039786 22059 50793 18392 18393 66634 26428 26429 56452 12575 12566 12447 12448 12576 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 73804 19053 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 17248 72155 26931 21770 26932 12428 70385 17246 57294 56455 226747 17120 26951 108000 229841 12237 12617 107995 72415 83815 12615 319152 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 12578 18472 67733 103468 66468 76464 66442 67629 235661 12427 56430 234865 56150 21762 12442 22123 60411 66336 59015 19179 69736 19181 67052 19182 232987 23996 12236 19184 236930 110379 26440 69928 19166 13427 76499 19167 13426 26441 52504 13424 26442 228421 69077 66997 23997 12234 56436 27214 17463 57296 20422 26445 26446 19172 70024 19173 19175 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 107823 67089 68251 103583 20184 70247 269582 70681 70238 27223 12795 107976 210766 59004 15204 19360 17535 21975 319186 27354 319178 12021 29813 319183 59092 319182 26374 81601 50883 327762 228829 319190 22427 19718 69263 15574 11920 319181 12189 235610 231724 237911 19355 56637 225182 93765 26909 235559 12144 68275 106344 72151 68240 19891 22631 19367 19356 22629 12649 217232 56317 59008 78303 18817 319188 66156 15270 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 382522 INITIATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769735.1 Initiation of coagulation cascade 15529 11603 14067 23888 20971 14066 20969 15530 14734 11905 14068 22371 14061 103978 71951 20970 14069 19128 14058 14735 14071 14733 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) 12091 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D 75612 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 12234 56436 17463 57296 20422 26445 26446 19172 26754 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 56637 667035 22190 59029 67089 70247 21762 22123 19179 19181 19182 18005 23996 19184 26440 60533 19166 19167 26441 26442 69077 66997 23997 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 96%190873 Gap junction degradation 14609 67300 13429 17920 11773 12757 13430 13132 74325 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation 20437 16334 11487 319149 106039 21810 68396 12307 11816 56224 69592 13010 15077 20219 67847 16432 20660 667035 23821 227753 22190 232670 51788 17304 230899 22139 20210 52588 70423 15874 100042305 208117 14161 59287 15267 100039623 319168 319167 12010 50873 17002 319186 319178 319183 319182 56791 319190 15530 11806 22284 319176 319181 20617 18550 11808 319169 625328 78303 319188 15270 74105 260302 11820 624153 20439 19109 382522 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) 14936 27357 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling 15461 56705 224116 18176 74334 15234 20662 17295 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 29813 328572 12532 104394 12534 211586 15469 22059 55948 21781 13197 20878 59035 12028 19650 19651 18538 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 96%5685939 HDR through MMEJ (alt-NHEJ) 12190 11545 19365 14156 22594 19360 225182 16882 17535 77782 11546 27354 MMR%REACTOME%R-HSA-5358508.3 MMR 17685 68275 17686 17350 17688 18971 68240 18972 19891 67967 16881 69745 26909 18538 18861 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390651 Dopamine receptors 13489 13488 13492 13491 13490 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000497 Scavenging by Class H Receptors 20692 238055 192188 192187 DEFENSINS%REACTOME DATABASE ID RELEASE 96%1461973 Defensins 22072 246082 12458 654460 654465 244332 629114 12504 12772 77674 24088 654464 21897 266620 654459 75400 11870 246700 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 18999 100038891 20674 OPSINS%REACTOME DATABASE ID RELEASE 96%419771 Opsins 13603 57811 14539 212541 12057 20132 353344 30044 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) 20521 PEPTIDE HORMONE METABOLISM%REACTOME%R-HSA-2980736.5 Peptide hormone metabolism 18508 17228 69940 16334 12387 245049 66482 14607 22226 22094 11891 12640 104158 13809 16000 16572 16573 12922 69048 14695 57394 14943 16574 234155 18548 27226 64337 17380 12876 12038 16790 76703 16326 11423 12873 70495 11421 100038824 16325 16324 16846 239436 12591 225642 18549 236781 13482 67475 16600 11606 66624 21416 14526 56373 70008 66286 17918 18453 16866 14463 53413 13033 76687 20336 107221 69019 14308 14688 107371 64138 233081 56529 16323 16322 105504 211446 18976 16392 102058 22318 13035 20907 242851 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME%R-HSA-165054.4 Rev-mediated nuclear export of HIV RNA 18141 107939 69482 71805 54563 19069 70699 72787 103573 18226 218210 69912 103468 19386 234865 59015 69736 110379 19384 170762 100088 108989 231042 19385 227699 223921 227720 445007 269113 66679 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 96%422085 Synthesis, secretion, and deacylation of Ghrelin 16600 16000 66624 12922 16334 14526 66286 234155 56529 18548 27226 12038 11423 22226 16846 76687 69019 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU 18550 GSD IB%REACTOME%R-HSA-3229133.4 GSD Ib 14385 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD 14629 14630 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades 103967 66105 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 13038 17087 21770 13039 26399 238055 26400 26398 26420 13712 26414 26397 17260 21898 23939 100561 20201 20202 11909 26419 13430 12675 216238 71398 27056 78287 16476 18033 18035 18036 24088 11820 21897 75669 81897 12234 56480 54131 225326 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 53791 107607 21899 69721 231130 93834 270151 16409 11596 22059 67454 240518 71966 108960 59025 100040260 16414 101568 235584 67603 319520 72349 170743 13040 14281 19141 170744 13030 22027 12370 54445 142980 19766 17079 11797 16803 56532 329547 17084 22030 19258 12475 22031 67245 56489 234779 69146 225471 11796 106759 21353 18034 71648 54123 54722 12229 434174 100041766 14082 66513 93765 66589 19247 22034 66724 68652 20111 13429 216080 12703 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856825 Cargo recognition for clathrin-mediated endocytosis 58194 20408 12402 56324 15239 20404 20844 20405 13858 13649 12500 21802 12502 12638 12504 12848 109689 216869 100043806 26891 11607 238055 12223 71920 13874 20508 15200 21336 22320 26893 17113 74325 26894 20955 18002 108679 26572 26895 16004 20980 22041 11839 22318 20979 13645 22042 11998 53330 11555 12000 22319 667035 22190 243764 16443 110355 100017 26754 13132 73094 14366 229521 194590 210108 233489 22418 11771 218503 11772 30931 71770 30934 74015 13854 108800 20616 20403 13855 67602 15463 232910 56017 11773 16835 13859 320129 12492 60510 269774 13543 14725 16197 55925 66147 67300 54609 12757 56085 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 96%1169092 Activation of RAS in B cells 15461 19419 240168 18176 PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling 233833 16451 21415 232440 12387 13200 13626 319149 72297 22628 16478 16842 12567 12443 15077 269523 66310 140858 97064 18566 52615 19646 213464 12988 11910 214162 13001 13000 100039026 17869 245688 20747 12500 22601 12501 12502 15251 23808 12504 18109 244373 18005 60533 76580 108099 16362 328572 66357 21414 21416 231051 18024 12914 21762 22123 19179 19181 19182 23996 19184 16476 18033 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 21679 15267 21676 319168 21678 319167 14281 226144 76850 239528 319186 21677 319178 319183 319182 193670 54197 236511 319190 26754 241113 14282 70377 319176 18034 216440 319181 20014 213988 57261 103963 217351 56637 214150 69038 13135 19247 13819 14969 14968 66753 67819 26554 14056 15170 116891 17454 20338 319169 67075 105787 108079 20846 19079 20848 108097 625328 78303 319188 15270 58205 16818 19082 80286 624153 68292 16430 382522 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation 216151 15278 21780 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME DATABASE ID RELEASE 96%5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 22632 18508 232440 13626 319149 15077 66310 140858 66420 69833 67710 52615 15399 245841 69920 19646 20022 213464 20020 20181 231329 20021 69241 17749 245688 100043714 55982 23808 19401 15267 319168 104625 319167 13654 319186 22658 328572 319178 319183 319182 17268 15400 17344 319190 16475 231051 15412 16658 18514 15407 67278 15401 13018 319176 15423 329559 319181 15410 103889 18771 15436 15434 15394 15429 58184 15183 20185 17979 218772 19411 12914 56406 14056 319169 22289 625328 16476 78303 319188 15270 624153 381022 382522 NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 18148 69912 16211 103468 19386 234865 59015 69736 110379 19384 170762 100088 108989 231042 227699 223921 227720 445007 269113 66679 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels 16520 16518 16515 211480 PI METABOLISM%REACTOME DATABASE ID RELEASE 96%1483255 PI Metabolism 101476 56209 225326 170749 320207 64436 320634 18710 19211 19249 104015 16331 16332 83493 77980 67073 224020 77116 30955 18708 18709 18706 108083 74769 18707 219024 18718 18704 234729 54384 17772 320981 216724 210376 66569 11840 241274 240752 18705 234129 104709 50767 18720 68616 18719 68365 18717 97287 233315 11842 106869 107650 103199 244882 18711 12169 233552 20975 268783 69769 74302 19341 56305 53332 219135 84095 319934 271457 240753 101490 231999 109135 19062 269180 75669 66443 234515 83435 83436 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome 268973 12362 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 20850 13856 13857 384783 16452 17096 20851 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855167 Synthesis of pyrophosphates in the cytosol 56409 217837 75678 102954 27399 271424 227399 71207 327655 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 96%9818035 NFE2L2 regulating ER-stress associated genes 12914 328572 18024 11911 17135 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 96%201451 Signaling by BMP 23893 12165 11705 110542 218441 12154 17129 18121 55994 66105 12166 12167 12168 11482 14314 20481 12156 17125 11481 12622 16323 17128 16322 21814 75788 66313 11480 17130 216080 17131 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 96%174403 Glutathione synthesis and recycling 14629 14598 14854 68044 69065 75475 23887 68252 71522 66054 207182 14630 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System 18796 18797 18795 17161 12326 14811 18039 14810 11472 20779 320472 23859 19084 14814 68606 52163 14813 26413 26417 18176 15461 13169 17920 108099 18607 14800 11438 110834 11449 110902 54526 640703 11435 11448 11447 11440 108015 108043 11444 110835 231252 20980 22318 20614 20979 20907 84036 18213 140493 16534 240444 75409 58802 16526 16527 216963 223604 386750 238076 15165 63993 15168 225030 16535 72413 16538 16539 16497 74571 14697 16512 98741 66733 380728 240595 72258 16528 14710 16490 14699 16491 66066 226922 14700 16492 216456 15166 192775 16485 170738 14708 16506 14706 16504 99738 110637 16493 14704 14807 16494 14806 16498 14695 13385 16495 14805 242151 52589 16500 53310 16502 14693 13383 268345 14809 13162 16508 64337 56543 14709 382571 241794 16510 211468 217826 20168 106025 16511 14701 14251 56379 211480 332396 16499 67498 238271 330953 435726 14702 14252 14696 19088 19108 11771 104110 14678 14677 14615 14679 14610 432530 55991 210044 14617 104111 406218 14688 224129 11512 11513 11514 11515 18749 14415 14417 16536 110862 242851 19085 13823 19087 16514 238276 60613 12322 16531 12323 16533 140492 108058 12325 192167 54525 233067 20910 57267 228836 331461 226352 18747 242667 56376 171180 100039592 272381 216856 58234 26558 26557 216028 74342 20928 26556 243961 110651 19024 20112 67533 12038 217692 268860 19268 12647 107065 11423 380785 67111 13822 22348 269587 214579 14816 224997 27204 60367 19339 245537 13002 108071 239250 20965 18189 20964 18190 68507 76965 327814 70530 12889 11784 22249 245450 791260 225875 15567 245446 12286 19280 12287 12290 53623 232333 14799 14412 57014 56808 17246 110304 12293 14680 12295 243547 12296 16559 12297 14802 12298 55984 243616 19417 233977 19418 14645 18693 214084 16519 20508 16520 65106 54393 20518 211323 20517 16518 12294 15561 22343 16516 14402 14401 14400 14399 110886 14397 14396 15481 14395 14394 16521 16522 16524 16513 16515 54377 21912 14409 74053 14408 18195 14407 14406 14812 16517 108030 64011 207565 14660 57249 12300 54376 18752 12361 12846 81905 14658 237213 14654 328699 319924 67071 170483 236915 22342 242425 18751 16523 20927 52150 16525 16530 241113 242607 14411 67760 19353 20513 11669 20511 20510 20512 20111 105727 60510 105787 108079 19079 108097 19082 18750 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose 22260 20181 20182 103968 22259 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 13124 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives 11686 23801 11684 14775 625249 14776 11687 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73772 RNA Polymerase I Promoter Escape 232440 319149 667501 21429 20019 15077 21340 21339 21341 64424 13871 75316 66420 70333 69833 66136 245841 20017 14885 209357 66467 66671 17749 100043714 17420 12572 13872 23894 14884 15267 319168 319167 319186 319178 319183 319182 319190 106298 319176 21374 319181 20018 20016 319169 12417 625328 78303 319188 15270 624153 382522 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696264 RND3 GTPase cycle 13836 14252 21927 74194 64652 232906 216197 12709 71435 20355 233877 12389 83669 13510 233489 12874 11855 232339 109620 208994 108686 19249 227937 67586 71228 93840 229658 226525 269608 13206 50875 19877 105782 16709 218581 17063 18708 19655 18709 53382 380664 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME DATABASE ID RELEASE 96%9665245 Resistance of ERBB2 KD mutants to tesevatinib 13866 59079 12539 15519 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 96%9036866 Expression and Processing of Neurotrophins 18552 18550 18553 18049 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 96%444473 Formyl peptide receptors bind formyl peptides and many other ligands 14289 14294 16952 14293 15199 20210 11820 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 108097 19094 26416 108099 19082 241113 19017 108079 29857 19079 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 96%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 70620 667035 22190 107823 68251 20184 240087 11350 70681 70238 27223 107976 210766 19060 104416 22059 59004 225896 14051 22196 93762 22385 11785 15204 230674 19360 14050 14049 17535 14048 319186 27354 12021 319178 319183 319182 81601 50883 319190 319181 11920 12189 319152 93765 193796 26419 78303 319188 15270 382522 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME%R-HSA-9865125.1 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD 12040 13171 12039 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME%R-HSA-9944971.2 Loss of Function of KMT2D in Kabuki Syndrome 66310 140858 213464 23808 381022 STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation 14389 20850 14256 14255 19247 20851 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 96%453276 Regulation of mitotic cell cycle 12234 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19645 19177 21402 26443 26444 12566 19170 66413 26965 56371 667035 27401 22190 59029 67089 70247 30939 18005 20877 12428 229776 12237 67141 107995 12427 56150 21762 22123 20878 19179 19181 19182 217232 23996 56317 12236 19184 59008 18817 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 69912 13684 103468 20492 19386 234865 54451 59015 69736 51786 94230 74320 21681 68188 54188 110379 66899 170762 108989 53319 231042 227699 223921 227720 445007 269113 66679 SIGNALING BY INTERLEUKINS%REACTOME%R-HSA-449147.13 Signaling by Interleukins 12402 20586 107746 12929 26416 12928 56044 18126 26413 26417 20416 19094 102626 26395 20662 17164 215449 216233 12700 22352 16452 15368 12609 17395 16172 17260 11909 268373 15234 20656 56484 16476 16906 22318 20614 20907 16819 11820 14103 257630 56480 171095 56438 68981 53379 98758 16176 12362 15162 12370 16173 22030 67245 69146 18453 16453 16177 54721 16175 20963 13609 434174 20847 17060 50931 50926 16171 66162 18569 12798 18738 50498 12931 11632 20849 209590 18826 17319 18788 16162 16161 246779 15526 16188 16185 12984 12982 16192 16191 13035 12575 12443 19249 16186 19250 19253 104831 19259 16331 19256 16332 16182 24058 16068 18747 320139 56294 19255 12491 73914 20969 73699 11799 110651 20112 16189 16163 19052 16174 19053 51792 93871 19373 19374 53603 16196 57914 21770 66902 26399 20293 26400 26398 26420 26414 26397 23939 16193 667310 26419 21351 100038891 12043 12048 16170 20908 76527 109658 19152 19283 242700 11687 16364 16195 12367 192656 17874 17258 20203 20210 19225 24110 11689 257632 266632 80750 223664 107607 69721 231130 93834 270151 16409 11596 22329 67454 240518 71966 108960 59025 16411 100040260 16414 101568 235584 67603 319520 72349 14281 224105 18034 15894 19247 15170 17390 20846 20848 16818 16451 17161 319149 22612 11651 22324 15077 18710 16153 71481 211550 21417 56468 26410 14360 17869 15251 17096 12504 22160 12772 12774 12768 18708 18709 18706 74769 18707 12519 18386 12524 12702 14462 16198 16199 16477 14293 16880 21454 12346 21682 20303 20304 20292 73086 20302 20297 100039973 20299 16184 16183 330122 16412 22059 14825 16803 19258 20851 20850 18712 14784 16952 15945 19248 20909 18986 12340 21857 12306 17829 21803 17698 20663 12330 331461 15519 17127 19204 667618 17392 16190 69677 100042555 13712 16156 83995 17984 18412 107527 16165 16164 14086 26406 19229 56708 19885 77125 50905 11840 18413 329244 15481 17210 237310 20955 213208 237313 54450 60505 338374 93672 58181 60504 116849 215274 69581 21762 16169 22123 16168 12675 140806 17082 19179 18414 19181 53314 19182 54473 23996 218624 19184 14873 215257 18033 234836 26440 13019 19166 230828 18035 57890 19167 12804 18036 12981 12803 26441 12978 54448 384783 26442 69077 66997 23997 12234 14389 56436 16367 17463 57296 20422 26445 26446 19172 19173 19175 56458 19697 19177 20674 21402 16150 26443 14173 26444 16151 19170 66413 26965 16179 667035 22190 18390 59029 26409 16194 67089 103583 70247 12986 19883 16181 16776 16878 14128 21937 21938 16178 14268 16160 16159 16155 16154 21926 12985 22027 12053 15978 12843 20911 20852 19188 66513 93765 66589 22034 66724 74145 68652 12631 20111 22631 16197 18976 22339 12977 12703 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 96%4641258 Degradation of DVL 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70247 26554 13542 21762 22123 19179 13544 19181 13543 19182 23996 19184 26440 19166 19167 26441 240756 26442 94253 69077 66997 23997 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%177243 Interactions of Rev with host cellular proteins 18141 107939 69482 71805 54563 19069 70699 72787 103573 18226 218210 18148 69912 16211 103468 19386 234865 59015 69736 110379 19384 170762 100088 108989 231042 19385 227699 223921 227720 445007 269113 66679 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-HSA-3134973.3 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 12914 328572 12387 54131 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9012999 RHO GTPase cycle 56324 20779 56374 15239 381293 20867 12389 83669 20844 18844 108670 12874 59009 232339 107746 14786 223881 208994 108686 66922 227937 20257 67586 71228 68187 93840 11671 327826 22325 77480 57257 246710 50875 29875 20662 19877 15381 83946 106504 52666 109331 16800 11465 263803 12848 52428 19230 13605 17920 270163 22352 20166 19878 236920 76626 26403 13830 56381 16480 19655 68743 53382 20874 15516 213498 70804 100043806 12704 269061 243362 26891 110596 56320 207212 109711 19285 12539 71704 20462 234094 69288 11464 242202 50768 56349 54216 16801 11852 404710 13367 75547 20868 268301 320795 109333 72754 208846 69632 213649 24001 224014 230098 53972 15369 30938 66508 442801 226970 235611 54126 101497 269608 14163 26382 268739 14674 73341 11853 16906 54411 105827 195727 210293 50884 71709 22042 83767 170758 329165 109934 106952 71893 26934 110279 330177 75409 105855 242687 216963 386750 17969 20947 212285 237038 70497 320634 27061 11308 20619 224480 11856 13058 241275 13171 13057 108100 76117 218952 26431 17970 101314 17972 66898 71302 71544 12261 14251 14252 67784 73178 78514 17827 68653 26554 226525 245880 22376 215280 68524 67299 330319 76884 66894 223870 19249 217866 105782 14269 22379 80837 214459 14467 66871 226751 76088 218756 18221 19418 21844 208869 107971 236915 16449 21873 13511 13510 109620 19299 58220 227377 224105 259302 223666 14270 117600 19353 20514 16818 18806 22324 269523 18710 72565 74201 12988 13206 12638 18708 18709 18479 18706 98386 101565 18481 19354 14609 12466 12468 22143 12461 11848 102098 56513 68146 22319 11855 277360 192662 263406 11857 14570 68813 11461 19349 18805 624814 70584 68428 56418 56384 70361 233103 229658 544963 622434 66251 68202 16412 545156 16443 13726 23943 75739 140579 628438 71782 17207 94176 330662 94190 16709 52331 218581 84004 21917 56491 109904 238130 230972 20430 223921 56419 380664 104445 56389 13836 59079 108037 69922 223435 330914 232906 56212 71435 228359 59069 12345 11352 53332 17974 67300 17063 17925 20740 214230 17973 20742 20663 241656 15519 21927 74194 64652 216197 12709 20355 233877 22284 19229 51796 53817 69581 238505 22637 213522 329366 56784 20401 233071 75974 12549 58996 66146 214345 208263 192652 239027 70350 74159 71409 74018 106326 244867 70598 192192 319899 260409 57778 386649 226823 21763 216445 69710 211499 244895 216831 268970 70719 328232 244418 101240 232201 73167 78816 228482 72729 104252 231532 68917 27360 69668 14218 71972 225358 214137 75415 171207 74734 71703 77038 228543 58804 56699 214804 269682 77006 223254 102075 66087 11736 23912 207425 19765 54004 73910 83397 269401 434204 207495 76763 94221 11858 213783 100038946 71085 545481 23853 210998 233489 219140 226652 14787 11854 232237 27984 75089 76577 20403 76983 106628 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 96%5657560 Hereditary fructose intolerance 230163 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206307 MPS IIIA - Sanfilippo syndrome A 27029 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME%R-HSA-9768727.1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane 66357 66624 19089 13200 12387 330914 12550 11735 66286 20014 18550 103963 18553 12330 69038 13135 76687 69019 13001 18554 13000 100039026 18717 56529 57377 217734 16480 99011 14376 16430 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors 67168 574402 18441 78134 18442 70839 57385 78826 74191 233571 11539 11541 235036 11540 140795 11542 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes 12914 52897 54526 19713 16334 17246 59027 243621 225872 12064 103573 20620 14579 14281 12569 12568 11863 11865 26413 26417 11864 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 18670 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B 74591 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 17155 17156 230815 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 97212 11363 231086 11364 67460 13177 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 96%8857538 PTK6 promotes HIF1A stabilization 93695 20459 15200 13649 15251 66725 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693616 Presynaptic phase of homologous DNA pairing and strand exchange 12021 81601 327762 20422 19361 114714 22427 19718 69263 15574 11920 12189 12190 235610 231724 237911 19355 57434 225182 26909 235559 12144 68275 106344 72151 68240 19891 19367 19356 12649 19360 17535 21975 19363 19364 27354 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 96%8876198 RAB GEFs exchange GTP for GDP on RABs 270160 22241 70785 235633 242406 192232 56382 60409 211922 225870 329260 216131 69440 19328 12663 217449 74018 11651 12662 11652 11891 19349 77980 19339 17274 80718 216363 66691 67091 66226 19324 19325 68328 75964 270096 217835 14569 68365 66975 14567 72433 227801 102442 66682 76954 106572 19347 229541 245828 72121 67790 72825 320714 226089 216344 59005 67844 270192 77407 74760 19345 319934 78232 245886 271457 320560 19344 319642 329727 22627 320435 19346 27096 226407 235442 105841 19330 56715 76308 74030 23797 76510 329877 209773 192236 GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation 242425 14697 14710 14699 66066 14700 14708 14706 14704 14695 14693 64337 14709 14701 14702 14696 14680 16519 16520 104110 54393 14678 16518 14677 16516 14402 14401 14679 14400 432530 14399 210044 110886 104111 14397 14396 14395 14394 14688 16521 16522 16524 16513 16515 14409 224129 14408 11512 11513 14407 11514 14406 16517 11515 57249 328699 236915 242851 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) 114479 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%450294 MAP kinase activation 12234 21402 73086 16150 16151 192656 16179 26965 667035 26416 22190 17258 26410 26409 26413 103583 257632 26417 107607 19094 102626 231130 73699 26395 110651 108960 20112 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 21770 26399 26400 26398 26420 13712 26414 26397 17260 66513 93765 66589 23939 22034 66724 68652 20111 11909 26419 12675 16476 18033 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6785470 tRNA processing in the mitochondrion 52575 68626 66132 15108 70047 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation 26445 16912 26446 19171 19172 19173 19175 19177 26443 26444 19170 16913 19186 26440 19188 19166 19167 26441 26442 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 96%186763 Downstream signal transduction 74769 17973 20779 20851 12927 20850 107746 14786 20852 12929 12928 19247 18595 18176 20846 20662 218397 20848 15461 17974 18803 18708 18709 18591 18706 18596 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 96%167044 Signalling to RAS 18211 19094 20418 102626 19730 26415 18176 20662 15461 17164 26416 56044 64143 18049 216148 29857 20416 ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors 11554 11555 11556 11551 11552 11553 11550 11548 11549 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes 12914 328572 18024 20293 17135 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-HSA-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes 15161 232440 20602 319149 23989 19645 217031 226976 208146 66853 59024 11450 18631 327987 76719 15077 57435 68801 66310 75812 21835 140858 14311 69556 69612 233904 68975 101206 14081 13486 234959 217588 213464 54194 108946 67933 665775 214162 75565 11350 228714 28077 70208 67773 239510 12491 21664 77305 75410 171285 23808 11520 56771 19014 328572 21372 231051 74322 17977 19017 17978 81004 69790 56310 208043 26896 15183 20185 93759 12914 56406 14534 22289 27273 170826 12568 381022 14732 20249 12606 20181 55982 15267 319168 319167 264064 319186 319178 319183 319182 228829 67279 108155 319190 16475 57875 67278 17283 23945 319176 101739 16890 16956 319181 14245 103968 17979 216154 67800 51813 11770 26424 319169 18519 69792 67512 625328 67381 78303 319188 15270 624153 382522 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 20181 20186 13123 104086 17977 13122 77337 208665 101502 83702 13124 17978 105349 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME DATABASE ID RELEASE 96%9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 13856 13857 18803 234779 384783 16452 17096 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 96%5675482 Regulation of necroptotic cell death 14103 56532 14252 74568 12539 22030 108155 56424 21933 67245 11796 11798 53378 667035 71609 22190 14082 15519 14102 14251 18571 22195 22035 50873 16396 12370 19766 11797 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 96%166016 Toll Like Receptor 4 (TLR4) Cascade 103967 66105 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 20201 20202 11909 26419 13430 12675 16476 18033 18035 18036 24088 11820 21897 12234 56480 54131 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 21899 69721 231130 93834 270151 16409 11596 22059 67454 240518 71966 108960 59025 100040260 16414 101568 235584 67603 319520 72349 14281 12370 19766 17079 11797 16803 56532 329547 17084 22030 19258 12475 22031 67245 56489 234779 225471 11796 106759 21353 18034 71648 54123 12229 434174 100041766 14082 66513 93765 66589 19247 22034 66724 68652 20111 13429 216080 12703 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity 56774 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis 268373 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173736 Alternative complement activation 14962 12266 11537 16904 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3359454 Defective TCN2 causes TCN2 deficiency 21452 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5675221 Negative regulation of MAPK pathway 16706 225849 26931 21770 26932 109880 667035 22190 26413 26417 29857 320139 17169 19060 54401 70686 73699 26395 26396 18176 75590 15461 110157 235584 231474 23980 67603 19052 18218 319520 63953 19053 13537 51792 19252 11836 240672 72399 226849 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) 17874 53791 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%189451 Heme biosynthesis 19044 70383 26357 15288 22276 12892 17025 11657 11655 11656 14151 226139 22275 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9920588 Dengue virus activates modulates innate and adaptive immune responses 317677 12759 23845 17195 69940 12259 11806 56489 236732 72512 20847 214763 13205 76246 15519 214498 66317 625018 69116 235497 22083 71586 228607 54624 217069 22370 15516 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 96%8964038 LDL clearance 100017 232910 11773 100102 16835 67963 238055 54135 11771 16889 11772 71770 67300 13909 12757 320024 223920 18145 20652 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins 56436 17463 57296 20422 26445 26446 19172 19173 56513 19175 19177 57265 26443 26444 19170 66413 667035 22190 59029 67089 93840 70247 105782 66313 106042 14367 14365 14362 14366 22418 14370 14369 21762 22123 19179 19181 13543 19182 23996 19184 75788 26440 19166 19167 26441 26442 69077 66997 23997 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%5660489 MTF1 activates gene expression 13007 104069 17764 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins 19763 13436 13435 13433 54383 13619 30951 241915 12416 22196 12418 19821 12151 22658 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811436.2 COPI-independent Golgi-to-ER retrograde traffic 28169 108148 56444 67665 56455 22428 12121 13191 76895 12344 18476 59288 69654 18475 53357 18472 234663 12343 12345 235661 12340 18783 68097 14423 54130 270192 53598 13427 19346 13426 226407 13424 19330 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9675108 Nervous system development 20437 20665 18992 58194 20586 20779 20404 17295 18844 14786 223881 26413 26417 20416 327826 22325 20418 26395 26396 57257 18176 20662 19877 15461 16416 11465 21894 19878 15516 213498 110596 17395 11852 65254 319713 14587 14586 20358 19122 69632 19197 12517 69585 210801 14588 53972 215798 114873 20346 19262 19264 216439 235611 20351 54126 12292 15357 244058 208643 110789 17528 22288 26757 19056 19153 83433 18845 22253 11853 17196 20349 140571 18858 22177 18846 231148 22240 57764 623279 13497 13508 76829 54712 12569 20361 12568 114255 18188 12933 110351 214968 11876 13449 13448 68799 226251 216963 56438 77579 71960 20354 20130 16885 16886 13121 20788 12830 13385 12829 12828 12827 53310 12826 13383 19164 19165 12841 100042305 208117 12840 59287 100039623 245026 12839 12835 12834 12833 67784 76709 53378 73178 11771 11772 71770 56443 22359 19699 13131 68089 67771 11867 56378 66713 18738 232910 74117 11773 218397 18749 13004 17909 18747 15529 110651 20112 14573 57294 14585 76707 14733 23939 18007 14812 14388 21844 18803 13835 76499 67071 11487 11603 227377 21676 224105 13654 19876 259302 223666 20563 14270 117600 19353 56637 19247 13848 13846 13845 270190 13842 13840 17390 13841 13839 13838 13837 13637 13636 13643 13642 13641 13640 13639 13638 18750 17136 14810 17936 17937 22612 18710 17886 97064 14360 13001 67268 13000 100039026 13649 22601 17096 18708 18709 18479 18706 12288 74769 18707 18481 107449 68092 107448 433702 67923 11848 14159 73086 11461 70584 19713 16412 545156 16443 330662 243743 58226 12291 13836 239556 67938 17904 223435 232906 17880 27207 67097 670832 633683 13866 20044 27050 667279 20085 668144 12289 20084 67186 382492 20055 75617 27370 18222 65019 16410 16571 20356 629957 14083 21367 20102 53870 268721 24046 20103 11352 13844 668668 14853 16728 667739 17974 12661 16825 16392 18187 67300 20315 13429 672214 170822 13193 12757 54003 19684 66481 71745 12934 225058 17925 16536 100038875 18208 17698 100038991 225363 110862 68028 14026 104099 100043000 17690 20739 67891 18458 20740 100043295 13138 235281 622534 14852 56613 238217 214230 74947 17973 20266 16785 16870 20265 666669 16871 12805 100040021 12767 11733 67025 268902 11735 100043391 326622 14432 668182 13176 640524 241053 18186 20742 16876 20741 432502 19087 319504 238276 20743 19989 20663 26394 76808 67252 20271 19899 12331 399548 100043184 241656 20272 19921 71436 20274 19934 18643 20273 100043755 18645 103967 22323 11658 16872 110876 67031 53321 319195 20564 20269 100043209 20562 72821 68193 15399 110880 621100 22350 19941 17967 665189 269116 666899 71653 100042670 80297 15519 20264 100039316 213119 11350 22121 56705 58234 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 20450 67941 20452 12295 12296 12297 12298 74325 15481 192160 13430 21762 22123 60365 19179 19181 19182 23996 19184 68134 26440 19166 19167 26441 192170 384783 26442 19826 69077 66997 23997 66441 14389 56436 17149 17463 57296 20422 26445 26446 18991 19172 19173 19175 19177 26443 26444 19170 22063 109700 66413 22065 16398 22067 667035 22066 22190 22068 59029 67089 70247 26946 16777 226519 16399 16772 16402 16773 14783 18761 12631 20111 18717 15182 20439 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance 232440 22589 217653 20892 233532 100038822 70645 66311 66578 12566 16881 13163 21752 19646 70454 71876 245688 320394 102920 28113 101185 26886 72155 12428 57321 12617 83815 12615 319152 66570 56505 21749 497652 21750 67733 76464 12427 60411 66336 69928 52504 208084 245474 14156 72171 214987 214901 20174 68964 72107 108689 69535 66181 216853 18148 68147 66420 69833 67710 52530 245841 69920 20022 20020 231329 18969 20021 18968 69241 17749 100043714 19075 19076 93762 15267 319168 319167 69745 319186 319178 319183 319182 327762 269400 319190 22427 19687 19718 319176 69263 319181 18538 105522 12144 68275 106344 72151 18971 67857 68240 18972 19891 319169 52036 67967 625328 78303 319188 15270 624153 382522 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 96%9824443 Parasitic Infection Pathways 17913 13479 58861 246256 17973 14131 17909 66824 330319 216799 76884 12495 19087 19084 22612 22324 217344 20620 93671 16153 17886 26416 12928 26413 229709 26417 14360 16438 16439 18747 22325 11350 16440 12502 57257 17096 11465 22166 15516 15368 18550 16193 640703 26419 16476 18033 18803 50884 83767 329165 71893 105855 11491 242687 19697 237038 11308 14697 241275 13057 108100 11461 14710 14699 66066 14700 101314 14708 14706 12266 14704 14695 14693 140579 64337 14709 16176 330662 12362 14701 15162 56338 140580 20430 14702 16173 14696 19088 234779 69146 17918 19108 12499 18034 12267 76709 73178 19353 104110 22418 20963 16175 14678 14677 12229 56443 14687 19200 14679 432530 210044 14369 104111 80987 68089 14688 67771 11867 54483 56378 18438 66713 74117 13542 70086 224129 245880 11512 11513 11514 11515 14191 18749 13544 14083 13543 22376 215280 14598 18439 319446 68524 67955 13035 11541 23959 17925 23887 17882 14129 242851 19085 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN 72935 72512 56480 446099 268857 54131 22596 207521 14375 17535 19090 22040 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.1 Aggregated β-amyloid induces FXII autocatalysis 58992 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors 15171 237362 387285 230777 229214 227717 104443 54615 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-HSA-2995410.7 Nuclear Envelope (NE) Reassembly 12534 53857 22152 227613 22153 238799 22142 22146 116733 67951 16211 73710 13726 22145 66371 71782 22196 545486 68953 238463 75608 19052 51792 19384 170762 100088 227699 208092 66700 445007 269113 380664 23825 107939 69482 71805 98386 226747 70699 72787 18226 105513 69912 103468 22367 71955 64383 224640 319965 234865 50850 12442 100042651 71978 59015 69736 22147 110379 16906 22151 22143 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing 11810 80287 11811 56417 69865 71281 110532 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD 11303 11806 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 17685 68275 17686 17350 18971 68240 18972 19891 67967 16881 69745 26909 18538 18861 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception 77337 83702 19230 11806 238055 640703 231252 22318 20614 20907 258299 258381 258992 258486 258650 258487 257884 18367 258991 258736 258097 258794 52250 14699 258857 259111 258836 258821 56858 258542 258405 258935 258420 258321 259036 259034 259119 14695 56307 18324 258697 258432 258675 258673 64337 258677 257905 258334 258025 667918 258832 77974 258469 258882 258601 258853 259112 258657 18366 235033 18328 258470 258600 258338 258455 259053 14919 258027 68453 56015 20148 67442 259041 258573 259049 98711 258563 259013 117004 19682 258846 258105 16956 20897 329460 216454 258854 258930 17252 258281 73582 241452 257962 105349 258387 18314 259063 258896 404315 258453 11807 257883 11808 104111 258586 258869 258587 14688 668825 258363 110606 80706 258362 257909 14272 258575 258358 258658 258616 16835 258941 11813 258944 11814 258618 18369 258216 237178 258866 258580 258582 15485 27400 241431 16971 73750 228228 140476 258160 16470 258267 17910 258350 23999 258544 22295 258772 17921 258640 667663 258608 381375 259015 193385 404329 242851 20776 259110 11994 546747 17913 13823 258636 227357 259109 192140 258715 13409 259014 238021 258395 628870 259051 332309 258680 18419 259045 97031 258155 80979 259100 17524 258154 56506 258805 102502 258147 224796 257916 72088 258572 67972 98845 258990 328789 18313 56226 258749 60613 258340 16531 433899 18331 16533 13860 259097 140492 329421 258036 504186 227753 258355 404318 259047 19892 258980 259004 258407 259017 75624 259019 15529 170639 23888 258371 20971 259113 258656 24013 258562 436002 20969 258424 16440 258752 18365 258939 258961 258268 258305 100038859 100043474 259074 258507 71951 258427 20970 259122 257917 404346 258819 258672 14735 259075 259040 259058 258746 57251 258614 19771 258700 258694 258478 258443 258178 546729 258222 258775 15530 14680 258352 258248 258831 258196 258458 18315 258776 259054 404317 103978 63857 55938 258720 16518 258985 258690 258373 404222 18317 258717 14733 258937 668035 259071 258292 258531 258756 258238 258710 259106 258322 258946 79235 258975 258763 170752 14734 258325 258536 258925 258924 245532 258706 404331 258302 258804 258713 239766 258270 258704 12361 259147 18343 18310 258310 258303 259115 259012 258357 258347 259035 258296 258179 259066 258206 259095 259092 65107 244187 67861 258098 259089 107477 258163 14913 224055 258914 258319 245650 258759 258609 257898 14685 258287 20215 258506 12788 258922 214111 258316 212541 258354 240669 18346 239393 259002 11304 258814 259067 258620 11603 258207 70061 18341 18357 18330 218066 258016 257972 29849 69060 258729 545140 109791 258769 257985 102294 19662 258075 258515 258439 19660 258271 19661 258408 13591 243923 19659 258153 18312 258481 258318 258275 404319 19674 20278 258151 258933 258039 18322 258908 258702 258703 258659 20276 21906 20277 243634 225600 233649 18750 12789 18587 18588 18796 18108 665270 17886 18107 14539 387513 387353 387515 353148 353165 387348 110326 83770 12057 22139 268934 83771 574417 387347 57253 57254 387355 387342 387349 387616 240899 83762 26875 12343 12345 12217 12289 216227 29866 20977 12340 16825 19684 17698 20740 20266 16870 20742 11816 399548 20274 110876 20269 72821 22350 14816 19339 13002 20964 56808 12296 68667 56843 18761 14725 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation 216848 12865 17977 19017 107932 70673 22227 12683 12686 94187 19646 234366 116871 12162 51810 116870 13592 20181 19013 245688 17125 19016 17128 23942 17192 433759 170826 15182 229542 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%383280 Nuclear Receptor transcription pathway 21833 20602 353187 13865 19885 13983 22026 20185 192292 225998 218772 217166 19411 23957 22260 21907 20181 22337 13864 19013 13982 20183 22025 20182 19883 11835 18227 26381 26380 26379 15370 19016 75692 26423 19401 19015 21834 18667 19014 30942 15378 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 96%936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 17087 56480 54131 12475 22031 56489 225471 106759 21353 71648 54123 667035 21898 22190 19247 VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 96%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) 102680 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-HSA-75105.12 Fatty acyl-CoA biosynthesis 14104 19063 257633 433256 83603 74522 54397 50790 15487 328845 74205 20249 57874 68801 14979 30963 170439 104112 106529 54325 66775 12686 94180 14081 107476 216739 74559 234309 243078 70757 56348 99035 26568 54326 26458 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME%R-HSA-9709603.2 Impaired BRCA2 binding to PALB2 12021 81601 327762 233826 19361 114714 22427 19362 11920 12189 12190 237911 57434 19360 225182 26909 17535 21975 19363 19364 12144 27354 ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 96%1482922 Acyl chain remodelling of PI 77582 18778 18783 329502 66857 271844 18779 26971 232889 225845 26970 26565 18784 18782 78390 66350 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 96%1234174 Cellular response to hypoxia 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 13856 230099 66413 66105 667035 22190 59029 67089 70247 15251 53417 328572 17684 16475 100041766 11863 13819 12914 101543 112407 112406 29806 319594 67923 21762 22123 19179 19181 19182 23996 19184 26440 19166 216080 19167 22339 22346 71745 26441 26442 69077 66997 23997 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5676590 NIK-->noncanonical NF-kB signaling 12234 56436 53859 17463 57296 20422 26445 26446 19172 19173 19175 19698 19177 21402 18034 26443 26444 19170 66413 26965 667035 22190 59029 67089 103583 70247 22200 21762 22123 12675 19179 22192 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 96%5218900 CASP8 activity is inhibited 14103 22030 71609 14082 22035 21933 12370 19766 14102 RHOA GTPASE CYCLE%REACTOME%R-HSA-8980692.2 RHOA GTPase cycle 12389 22324 22325 57257 29875 19877 52666 16800 263803 22379 52428 13605 270163 20166 19878 236920 13830 16480 18708 68743 18709 20874 213498 70804 12704 243362 110596 207212 19285 71704 234094 98386 11464 50768 56349 54216 16801 404710 13367 19418 75547 20868 268301 320795 109333 72754 208846 69632 213649 53972 15369 442801 226970 54126 269608 268739 21844 54411 22042 213522 109934 106952 26934 110279 12549 11848 58996 102098 66146 239027 74159 21873 212285 27061 244867 22319 20619 11855 277360 11856 192662 263406 11857 21763 216445 69710 18805 19299 211499 216831 56418 268970 70719 71302 70361 71544 229658 73167 78816 228482 545156 12261 231532 69668 17207 214137 94176 171207 94190 16709 14251 52331 218581 84004 21917 56491 109904 77006 223254 223921 102075 56419 66087 56389 14252 59079 73910 223666 223435 117600 330914 232906 71435 228359 100038946 71085 545481 23853 226652 14787 76577 78514 76983 17925 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665686 Signaling by ERBB2 TMD JMD mutants 13866 59079 12539 13649 18183 83961 100042150 12223 18176 20662 13874 15461 15200 211323 18803 13645 20416 15519 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME%R-HSA-9022699.2 MECP2 regulates neuronal receptors and channels 19258 14811 26913 14812 17295 20466 22065 14229 433759 18387 19246 18390 15182 14800 20527 ACTIVATION OF PKB%REACTOME%R-HSA-165158.6 Activation of PKB 228775 75778 11652 18607 PDGFR MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9674428 PDGFR mutants bind TKIs 18595 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855183 Synthesis of IP2, IP, and Ins in the cytosol 56727 114663 55980 71780 212111 16329 320634 54384 104015 210376 269180 16330 234515 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 96%381426 Regulation of IGF Activity by IGFBP 94111 20750 13406 30060 15464 11704 19089 71421 217847 18491 77583 105348 80752 23850 16852 18220 11816 15160 66853 626834 20856 381677 66848 338366 83554 11576 12558 66557 98170 17182 14314 16425 232146 12155 76453 74761 15529 16002 16000 100037258 14161 71853 29817 99571 22393 12159 216197 11806 238055 14061 83995 16193 385643 14734 19123 12870 22041 11820 14456 11487 64654 11905 13010 17304 18619 56453 12266 625018 14943 16777 21923 16779 226519 14268 16709 14118 382014 22027 12321 100102 17283 20255 18453 16009 16006 66113 104009 11657 20703 11625 11807 14067 17390 21857 18815 16008 16005 269181 66940 208659 13003 13602 16007 16012 75396 16011 16010 13035 246228 12977 13801 11804 12653 11698 20254 56047 268977 19672 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex 56438 667035 13871 22190 66420 67439 69833 67710 245841 69920 20022 14885 66983 209357 71101 66467 71991 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 23894 14884 11834 12848 100043806 26891 319955 26754 56031 26893 21399 26894 28000 108679 252870 22590 26572 26895 57905 99375 72584 13194 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication 319178 319183 319182 232440 319190 319149 16646 16650 319176 319181 15077 50793 18392 18393 26428 26429 56452 16211 319169 625328 15267 78303 319188 319168 15270 319167 624153 319186 382522 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 96%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 18969 18968 19052 19053 51792 19075 19076 211586 13555 73699 19645 21781 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT 21415 20682 232440 12387 319149 20586 84092 16842 68031 11651 12389 11652 21951 74493 15077 66310 140858 12005 21752 213464 20668 234130 73016 13001 84035 13000 228770 100039026 103236 17869 56811 20680 24117 75410 14296 73699 74499 207742 14160 20319 20377 23808 20187 20675 20677 212398 19052 100683 107515 19053 66313 192199 51792 77578 68911 12006 67772 67087 80288 16974 13380 16973 329252 73739 226849 72135 225849 328572 20679 68339 26931 239405 21770 407821 26932 21414 21416 103573 319152 56505 72780 214498 12914 235497 21762 22123 19179 19181 19182 23996 19184 26440 19166 13016 19167 26441 240756 26442 11789 94253 69077 66997 23997 27373 12234 93687 56436 17463 57296 20422 26445 26446 19172 19173 19175 72345 19177 20674 56438 57265 26443 26444 19170 66413 667035 22190 216795 59029 67089 70247 21885 21886 21888 22417 15267 319168 319167 319186 319178 319183 319182 81601 319190 20671 14367 17283 14362 12399 22415 319176 11798 14366 22416 319181 22418 14370 56637 14368 22423 20890 22408 21887 26554 18719 13542 319169 22631 13544 13543 625328 78303 319188 15270 433759 624153 382522 SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells 14389 74769 18707 210710 12402 234779 20779 22612 667035 22190 19247 16331 14360 16332 20416 17096 20846 20662 20848 17444 16653 15162 107829 12977 12978 18708 76527 18706 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 96%392517 Rap1 signalling 18747 109905 380711 20469 19419 54401 22631 18749 110157 215449 56508 223864 110351 19395 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 67728 116905 67228 105638 99349 13629 66632 69740 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching 19876 17974 268902 20562 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 96%4420097 VEGFA-VEGFR2 Pathway 18762 17973 12388 11848 12387 105855 242687 12562 76884 17969 11651 12389 11652 11308 22324 13058 19303 13057 26416 108100 12928 18751 17970 216148 101314 229709 17972 14360 16438 29857 16439 15519 18747 22325 19094 15507 102626 16440 26415 18753 57257 140579 18176 19877 16416 15461 330662 17164 78757 228775 20698 19878 140580 224105 16480 18708 75778 18709 20430 18479 18706 18607 12385 74769 18127 27371 230126 18481 56717 19353 12927 19229 227743 640703 109270 245880 16410 218397 18749 14083 17974 18803 16542 50884 56716 18750 83767 26362 23797 329165 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-HSA-9933947.1 Formation of the non-canonical BAF (ncBAF) complex 67155 20586 210982 105246 20588 243842 56456 269397 68094 83796 66993 83797 268996 12055 12054 11461 77045 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) 15932 REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity 14950 15368 12013 18024 17135 FRUCTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70350 Fructose catabolism 230163 235582 16548 225913 11668 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 96%2132295 MHC class II antigen presentation 74947 16570 20743 20404 103967 12330 73470 16563 16568 234663 19025 68097 73804 53598 13038 56444 13039 67665 22428 56455 13191 12344 59288 16594 229841 668303 16579 232943 13036 13034 19348 229445 56464 71819 226977 16593 16551 110033 280408 16149 209737 11840 74764 15002 15001 64291 16768 15000 14998 235661 13430 110379 13427 13426 13424 228421 26934 66397 69608 218811 99683 19349 77371 20334 16572 16573 65972 13040 19141 11768 11769 13030 108012 11764 11765 11767 252903 69654 11771 11772 71770 13033 14969 14968 69162 12343 12345 232910 11773 16569 12340 13032 16571 54130 67300 13429 12757 REPRESSION OF WNT TARGET GENES%REACTOME%R-HSA-4641265.5 Repression of WNT target genes 21885 21887 21415 14797 13017 433759 21414 13016 21416 21886 21888 16842 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11666 15488 113868 68801 54326 170789 56473 76267 54325 20280 12686 14081 HOST INTERACTIONS OF HIV FACTORS%REACTOME%R-HSA-162909.3 Host Interactions of HIV factors 14360 16211 19386 12504 19384 100088 19385 445007 12487 103573 107951 11840 69912 108664 103468 268373 67923 234865 21762 22123 12455 59015 19179 69736 19181 19182 23996 19184 110379 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 18148 667035 22190 59029 67089 70247 94176 15007 15162 170762 12010 12526 224105 108989 11768 140580 231042 11769 227699 108012 223921 11764 227720 107975 269113 11765 66679 11767 18141 252903 23825 107939 69482 71805 11739 433923 11740 54563 16646 19069 15361 70699 101739 72787 18226 218210 19353 11771 11772 71770 232910 11773 75717 16818 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins 16993 15446 11687 11689 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 96%6802953 RAS signaling downstream of NF1 loss-of-function variants 15461 18015 101809 114715 114716 18176 EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 75705 13685 13684 208643 217869 226982 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 13665 67204 108067 217715 26905 13667 209354 224045 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 18458 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME%R-HSA-168274.5 Export of Viral Ribonucleoproteins from Nucleus 18141 107939 69482 71805 54563 19069 70699 72787 103573 18226 218210 193740 69912 103468 19386 234865 59015 69736 110379 19384 170762 108989 231042 227699 223921 227720 445007 269113 66679 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399719 Trafficking of AMPA receptors 53623 14799 17246 243547 14802 238276 18693 11771 12322 12323 108058 12325 18751 14800 54377 21912 13385 74053 18195 13383 12300 54376 18752 81905 17920 18750 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor 14069 22371 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 96%6791465 Pentose phosphate pathway disease 19895 21351 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 96%69052 Switching of origins to a post-replicative state 52717 56436 99152 17463 668450 67177 57296 23834 20422 26445 26446 57441 19172 19173 19175 19177 21402 56438 26443 26444 12566 19170 12447 66413 26965 56371 667035 27401 22190 12448 59029 67089 70247 12428 17216 17215 17217 17218 17219 17220 50793 18392 18393 66634 26428 26429 56452 12427 21762 22123 19179 19181 19182 217232 23996 56317 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%901042 Calnexin calreticulin cycle 193670 227619 54197 19089 116891 20338 74126 66967 192193 12317 223455 66597 14827 320011 23802 22644 216440 66435 108687 75841 12330 667035 22190 14376 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME%R-HSA-9927418.2 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 11839 21802 13645 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis 20020 231329 20021 69241 17749 236511 100043714 192119 94223 23992 21357 75284 72322 14000 66420 214150 19384 69833 67710 245841 69920 20022 76850 239528 NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 96%9032759 NTRK2 activates RAC1 19353 18212 208869 12064 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9678110 Attachment and Entry 269523 50528 70008 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema 58992 16621 12258 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73857 RNA Polymerase II Transcription 20682 12389 12640 269061 18550 20869 64930 66508 545987 54170 22084 52187 68576 66096 83409 74370 68441 19042 268706 83701 245670 20683 18044 18045 18046 14732 14102 12362 16396 670717 56424 21933 22061 12028 64144 20926 93736 70122 74427 73473 12322 12323 108058 12325 18747 12418 77683 22166 12151 17248 17165 19763 12428 17246 54383 13619 110147 26399 241915 12416 19821 12579 12578 16193 494448 12427 12608 30951 12064 14812 13388 16449 384091 666609 27374 20638 56698 67332 29813 59092 50883 228829 12326 14811 20620 70625 68975 227644 13865 243963 77634 234959 20841 12419 102209 21418 330959 76184 75627 94112 15213 67268 70208 17988 21849 69020 13649 21802 14723 55948 94093 228876 15111 67731 268417 14751 23942 209225 56771 50493 21825 80509 104625 22160 21815 67911 214669 226896 240068 13395 108083 21833 15257 13038 77827 18983 98386 13039 210104 384763 239985 72611 269704 12702 14462 16854 14461 228839 14460 71361 14463 16477 233107 14776 56310 72780 237775 208043 26896 14800 15258 218772 19411 103988 52897 75747 80707 54526 16880 14534 17700 244556 12857 110109 619310 12450 12452 69131 30944 237758 53621 110323 19664 72068 229543 14579 70422 12861 109077 232791 68510 19650 71177 17863 18987 19651 210925 12862 109019 17865 18130 12868 75137 68943 77065 66142 269344 216848 69917 232232 93697 12866 68991 12865 192657 233056 69882 100041785 72656 208836 231571 77519 218333 109648 71957 18129 101861 18131 70885 170936 71793 18132 225283 107932 57432 666581 70470 12662 675812 72119 243834 170787 18148 53376 19211 333182 22775 239546 230899 75605 68428 16184 216456 16183 434377 66494 110052 100039786 19712 19713 71131 619331 26992 243906 15510 22648 381549 71063 319974 68742 235682 68094 83796 83797 57376 72720 19246 243743 244713 544922 380975 72306 268936 229542 434178 22658 12705 22750 17684 23988 67279 19258 72154 59027 67057 225872 17283 17992 69076 18718 18741 74400 15228 56353 230162 72723 22704 14229 22757 226830 70315 21349 210135 93836 193452 18986 11864 67821 244349 80902 13866 13864 74747 210503 93681 57264 232784 330301 74120 18519 449521 245368 15370 109594 17702 22654 16909 11783 56707 16825 57745 69562 242109 64384 22761 30942 15378 195522 77044 18534 103836 22632 20750 269870 12020 20393 20375 22696 18854 245595 56314 353187 70227 79221 110616 11816 59024 327987 72180 236193 432769 66105 67296 52712 231866 233904 22294 20135 234725 192292 83766 80751 23957 21907 11350 20482 20492 74570 72290 20481 116748 20183 20182 71041 75410 101095 238690 17125 17126 17127 17128 69181 75692 76073 17192 12741 66313 17130 21981 17131 17132 228140 67235 268859 56744 103806 56525 14312 16600 70088 13496 53325 69125 22640 209456 11604 219024 228491 219103 333639 22284 56456 18124 66813 53892 22062 319801 213011 223272 99890 69790 22678 68527 58184 19885 243372 22026 225998 52679 50496 22608 13559 104394 241764 12858 93760 233893 66923 107986 353310 76390 21762 13198 22123 14634 13197 14633 19179 57748 19181 14660 19182 67956 23996 268973 19184 75788 18033 230784 26440 16653 19166 170826 20463 19167 170574 12981 26441 12978 74352 26442 64050 69077 76367 66997 381022 23997 69260 14381 56436 14377 17463 78893 57296 19293 20422 70472 26445 16334 26446 327963 19172 69228 19173 225655 19175 56458 19697 239652 19177 52846 21402 94223 78251 26443 21388 26444 18091 332937 19170 21423 231464 232854 66413 22709 26965 16179 667035 18387 22190 18390 18751 64058 240064 59029 21408 13983 67089 75613 14219 70247 21406 68744 22260 17708 20181 17709 22337 17710 19013 22693 16408 13982 12795 22025 14431 19883 26913 11835 72739 18227 72556 14815 26381 272347 26380 208727 26379 19016 57913 22196 16399 12366 16401 26423 16402 19401 106931 12368 21834 20787 18667 233060 69234 19360 56338 13831 264064 17535 12053 21975 12359 18022 19364 84682 27354 15978 12021 12843 12842 20807 81601 56187 327762 54601 19352 17386 19361 330463 170740 243621 22427 333654 12399 19718 192651 69263 20371 15574 20604 11920 16009 16006 12189 83814 22689 235610 68036 231724 12227 237911 15185 19355 12122 66262 225182 12142 15184 26909 22751 18538 27274 235559 11863 17433 12144 20527 216154 68275 20467 106344 78783 72151 211651 14088 68240 51813 12156 252870 19891 72230 15469 212712 12177 19367 69792 19356 12417 15205 20878 20466 12649 108961 217232 18996 56317 18997 59008 67381 19015 66156 72805 216080 12905 69957 219022 17222 22339 75430 56222 68612 666311 52563 15182 22194 71393 68999 15194 52206 12226 100039535 319530 52717 244219 99152 22690 668450 17187 12534 100041581 56275 12387 20602 11906 23989 67155 20586 170753 20779 20588 20587 56461 17295 60599 67338 270118 235956 13345 21936 241196 235028 26416 433766 66214 12005 29808 16656 234366 26413 18787 26417 240087 77976 12545 107568 67370 28077 56233 19094 234594 382985 15214 244216 54401 171285 21420 21419 19014 11865 328572 21372 19017 103573 59035 81004 66993 17260 15183 20185 93759 217166 12914 11909 640703 18019 20656 56484 16476 18477 21672 66899 22627 12569 12568 12125 14103 12532 18128 56438 12918 16147 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 14415 74320 14417 68188 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 12447 56371 27401 13163 12448 12576 73699 11799 19052 19053 51792 20877 26931 76246 214498 66317 235497 22083 54624 18861 17685 17350 21872 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 21679 15267 21676 319168 21678 319167 14281 76850 239528 319186 21677 319178 319183 319182 236511 319190 241113 56717 319176 319181 213988 217351 56637 214150 227743 19247 14056 17454 319169 109270 105787 108079 20846 19079 108097 625328 78303 319188 15270 19082 56716 624153 23797 382522 233833 21415 232440 13626 319149 22628 16842 22612 11651 11652 15077 66310 140858 97064 52615 19646 213464 214162 13001 13000 100039026 17869 245688 22601 23808 78757 108099 12477 18607 21414 21416 231051 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 229906 235459 24074 83602 58202 68153 74197 67923 27224 27632 24116 12455 72949 13716 63856 22059 21803 54188 11545 54196 69257 13709 12143 18507 12400 225207 20674 22065 18761 22631 22629 18976 433759 16590 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9865881 Complex III assembly 72795 107197 66445 67003 22273 66694 15526 100042918 66576 14297 67530 544717 56046 100040287 380840 17711 22272 66152 75530 67267 56384 66821 100900 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 96%5218921 VEGFR2 mediated cell proliferation 18762 640703 16440 18753 18176 218397 15461 18803 16542 20698 18751 18750 229709 16438 16439 18607 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9608287 Defective MUTYH substrate binding SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR 17202 17201 20779 22094 12640 18754 18755 320127 26413 76192 26417 104418 56077 66082 22325 231871 380921 110524 269060 110197 217480 13139 331374 140498 212108 57257 19773 242093 18176 381489 20662 19877 239336 16336 15461 23919 52666 16800 13605 109689 19878 216869 213498 207212 71704 234094 56349 16801 11852 75547 72754 69632 213649 24001 224014 230098 53972 30938 21390 77669 442801 226970 235611 54126 101497 14673 269608 640703 328967 14163 19055 26382 19056 268739 19419 14674 73341 11550 11853 19058 11548 11549 12568 11820 109934 11554 11555 11556 15560 15559 15558 213788 15557 13492 57265 382348 13733 13491 381853 13490 14607 13489 22226 13488 14697 111174 93897 215855 19206 503558 54598 215854 22412 12672 216795 12671 19226 15552 14710 15466 14699 15551 66066 15550 14700 243764 22410 12669 93896 15465 22414 99296 22411 18241 14708 209512 14706 15566 22409 15565 12310 15563 14704 15562 11516 225192 14695 14652 11517 12311 14693 20423 64337 14709 15874 12921 12919 22417 12918 14701 114640 223780 54409 19227 19228 56089 213527 51801 13363 14602 14601 319757 11535 14702 93735 83428 14696 14527 14526 14367 14365 19088 26364 14362 22415 19108 14366 22413 12267 22416 22420 22418 104110 14370 22354 14678 22422 14677 13609 14371 12229 22421 22353 14687 20287 14368 14679 22423 432530 14369 210044 22355 104111 20890 19057 19207 14688 22408 16147 70086 224129 11512 11513 11514 11515 18749 11541 242851 19085 58861 12322 12323 108058 12325 229709 16438 16439 18798 18747 16440 73699 110651 20112 19052 19053 51792 21770 14680 55984 20293 19418 54393 23939 21844 207565 18752 236915 242425 18429 11998 18430 54140 26361 12000 14685 212541 20210 15139 12266 104709 207911 18750 23797 18796 18797 14686 18795 12326 320207 19084 11651 11652 22324 18710 13649 14419 12772 12774 12768 30955 80901 18708 14747 18709 84112 18479 20607 387512 59289 18706 12776 18607 12775 12458 12773 12771 170458 18386 18389 14539 23925 19214 243270 239283 387513 19222 14427 19217 18166 19218 19219 18167 18168 14294 12802 14293 12801 14309 387353 387515 353148 12765 227288 14308 56838 57811 17773 244701 353165 387348 387356 19156 20605 19065 20606 19064 211578 80885 272031 12145 20609 20608 14428 13051 227289 75769 217212 208990 216152 22439 110326 83770 20132 140795 57349 17171 30878 623503 107522 17329 20290 11848 17200 102098 18155 55985 20303 109648 20304 12057 20306 14675 20296 20292 24012 20302 57385 19739 20295 20297 100039973 74191 50782 100038965 277360 20299 13610 56066 20311 50779 20312 20300 11539 11540 18610 18619 229791 235044 11542 252837 66102 13611 14672 622434 22095 330122 51791 14823 12922 14608 16412 108073 67839 545156 268934 23984 16443 94226 241489 14676 108069 19049 108068 67792 20310 58175 14825 18545 353344 218461 14429 18577 17207 14764 110385 13603 238871 11609 207728 23796 54611 14682 83771 18584 574417 67865 387347 71729 57253 18583 12777 80910 57254 381413 109904 387355 93690 387342 238725 230972 387349 626596 226278 71223 12766 239530 226304 383563 387616 76123 321019 29863 12778 14761 381073 26385 110168 106512 75805 223435 436440 76854 12769 64095 15199 230857 23945 14763 54199 70839 19045 171469 16866 16867 227326 14739 12854 13349 16952 15945 20315 12767 19087 20663 14459 53978 22044 22045 624910 57260 233571 235036 246709 13617 19734 30044 14715 14714 13615 18441 246691 18442 100039592 14745 16963 16995 208188 229214 56183 56696 210198 58182 19204 104443 224065 19216 19220 64214 319239 14816 14289 12374 108071 238377 14744 225642 50778 56744 19735 50780 19736 14829 67168 21333 11606 11607 12061 12062 17392 56470 216749 21338 19737 14064 65086 14063 14062 14061 21337 15200 23832 319197 21334 21336 240816 12424 12425 12426 217369 227717 14065 381810 107221 280287 24111 574402 78134 100043254 237362 385643 433292 246313 233079 233080 233081 50501 67405 18216 14773 54615 12209 78826 114229 15171 110312 18217 387285 230777 11551 14767 11552 68039 11553 18101 56533 18576 22065 18387 18390 18751 22068 26946 18753 18783 110355 18575 18574 18573 16402 319430 12273 20604 18761 19395 20111 320129 13616 13614 18976 17199 13618 17203 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 96%5579031 Defective ACTH causes obesity and POMCD 18976 17200 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 96%2426168 Activation of gene expression by SREBF (SREBP) 73166 110196 14137 14104 100040592 21372 20683 109151 18044 18045 17977 18046 235293 68603 14732 17978 59035 20775 81004 20249 66993 192156 170439 13121 20788 13360 107476 100705 14593 16987 17764 12914 20181 319554 56406 17855 19013 19014 229003 NUCLEOTIDE CATABOLISM DEFECTS%REACTOME%R-HSA-9735786.3 Nucleotide catabolism defects 18950 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 16151 14082 71586 230073 12370 12675 16150 71956 228607 19766 217069 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.2 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 232440 20602 319149 23989 19645 66853 59024 11450 14732 18631 327987 15077 57435 20249 68801 66310 21835 140858 14311 68975 14081 234959 213464 12606 20181 11350 28077 70208 12491 21664 55982 171285 23808 11520 56771 15267 319168 319167 19014 264064 319186 319178 328572 319183 319182 67279 319190 21372 16475 231051 57875 17977 67278 23945 319176 19017 16890 16956 319181 17978 81004 14245 69790 56310 103968 26896 15183 20185 93759 17979 216154 67800 12914 56406 51813 11770 26424 319169 22289 27273 69792 67512 625328 67381 78303 319188 15270 170826 12568 624153 381022 382522 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%2408522 Selenoamino acid metabolism 622534 238217 16785 666669 100040021 67025 100043391 668182 107508 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 50493 667618 100040970 267019 56040 67248 100040331 67941 12411 57294 107869 11720 269378 18113 140483 667035 21743 214580 20768 211006 50880 20226 14711 65967 75420 27207 67097 670832 633683 20044 27050 667279 107045 20085 226414 668144 97541 20084 67186 216443 382492 20055 75617 27370 65019 105148 629957 20102 231872 20103 66143 668668 667739 672214 66481 23971 225058 23972 100038875 104458 100038991 68028 100043000 85305 67891 100043295 13722 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins 11687 11689 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 96%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) 246049 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway 14381 19895 66646 21881 110639 21351 19139 66681 74637 66171 232449 71336 110208 75456 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis 56436 17463 57296 193670 20422 54197 26445 26446 19172 19173 19175 19177 70377 26443 216440 26444 19170 269523 66413 667035 22190 59029 67089 70247 66753 67819 116891 20338 21762 22123 12638 19179 19181 244373 19182 23996 19184 26440 19166 19167 26441 226144 26442 69077 66997 23997 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 96%159418 Recycling of bile acids and salts 76408 20181 12012 20186 17977 20494 20493 28253 106407 17978 330962 26459 170460 27413 11657 16204 28250 SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.5 Signaling by RAS mutants 16706 20779 12322 109880 12323 108058 12325 26413 26417 12988 109905 640703 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 16653 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 96%5218920 VEGFR2 mediated vascular permeability 12385 12388 12387 18127 12562 18481 56717 11651 12389 11652 19353 22324 227743 15519 22325 640703 109270 57257 78757 228775 224105 16480 56716 75778 18479 23797 18607 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5607761 Dectin-1 mediated noncanonical NF-kB signaling 12234 56436 53859 17463 57296 20422 26445 26446 19172 19173 19175 19697 19698 19177 21402 18034 26443 26444 19170 66413 26965 667035 22190 59029 67089 103583 70247 22200 21762 22123 12675 19179 22192 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013149 RAC1 GTPase cycle 214230 18806 330319 76884 20663 12389 22324 241656 18710 22325 57257 29875 20662 52666 13605 226751 76088 18708 18709 18479 213498 12704 18706 234094 98386 50768 64652 18481 404710 19418 320795 109333 213649 24001 230098 53972 66508 442801 226970 54126 101497 14674 73341 21844 208869 105827 195727 210293 50884 22042 83767 213522 329165 109934 106952 20401 71893 233071 16449 26934 75974 110279 12549 330177 58996 102098 105855 242687 56513 216963 239027 17969 20947 212285 237038 74018 70497 244867 11308 22319 20619 11855 224480 319899 277360 192662 13058 57778 263406 241275 11857 13057 108100 68813 76117 216445 19349 218952 69710 18805 26431 17970 70584 101314 216831 56418 17972 66898 70719 71302 71544 233103 229658 544963 232201 78816 227377 16412 545156 231532 13726 23943 75739 225358 17207 214137 94176 75415 330662 171207 94190 16709 218581 84004 21917 56699 214804 224105 109904 238130 223254 20430 102075 56419 380664 104445 13836 19765 259302 59079 223666 69922 14270 223435 117600 330914 232906 71435 228359 213783 100038946 23853 73178 19353 219140 226652 20514 232237 78514 245880 22376 215280 11352 68524 17925 67299 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 96%5579013 Defective CYP7B1 causes SPG5A and CBAS3 13123 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69275 G2 M Transition 20873 68121 56299 29870 12534 78887 12575 217653 22628 100038822 225745 231123 12566 74360 18536 56371 66296 214552 19646 18541 75786 15519 18747 21664 71909 237222 73699 17997 18005 19052 73738 19053 68475 51792 53598 208518 236266 15516 328572 12009 99100 103733 22154 12428 74470 104318 56455 101565 16328 219103 108000 259279 103573 83922 171567 51885 72415 26370 76789 72083 76707 233276 103768 74237 13589 18472 12427 21762 12442 22123 19179 19181 19182 23996 19184 26440 19166 13427 19167 22627 26441 17931 22390 13424 26442 17865 72568 69077 66997 12530 231506 23997 12531 27373 629959 12234 56436 12532 17463 75660 57296 20422 26445 26446 19172 15366 19173 19175 268930 19177 21402 56438 26443 26444 227613 19170 72119 22153 66413 26965 667035 22190 22142 59029 67089 103583 70247 66671 17420 22145 12572 22059 14235 100986 16475 19088 230376 69654 231863 71648 17274 75296 72590 30949 77011 72486 19046 12537 77744 219072 225659 76478 78177 28135 214444 71978 76816 20878 54130 18817 381644 448987 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs 72290 116748 20638 384091 666609 243963 68092 67332 433702 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 96%5663220 RHO GTPases Activate Formins 223701 18643 18645 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 11465 73804 19053 22379 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 11852 26951 13367 108000 229841 12237 103573 12617 107995 72415 83815 208846 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 11853 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 13426 52504 13424 228421 11848 71409 57778 11461 16412 56419 20807 14270 19353 11854 320271 13542 13544 13543 18817 14026 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B 52717 99152 668450 12534 107995 217232 56317 59008 66156 667035 216080 22190 69957 17222 75430 68612 52563 22194 68999 52206 100039535 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 96%8978934 Metabolism of cofactors 18127 11651 11428 20751 71365 67426 99138 320415 15519 14528 242642 76889 217707 230027 640703 67914 19286 56075 12850 71883 227683 52064 13361 15926 19092 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 96%9635486 Infection with Mycobacterium tuberculosis 672511 12721 16646 15239 19720 13806 233405 667035 22190 19349 18126 26413 26417 108664 71514 18655 16211 70686 606496 271457 12010 13035 17002 24088 17533 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576890 Phase 3 - rapid repolarisation 16511 16493 57814 246133 100986 16535 66240 16509 57442 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion 12631 14159 18481 18845 18186 18844 19353 18846 16885 243743 224105 20346 18479 15516 14360 15519 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190372 FGFR3c ligand binding and activation 14172 80857 14425 14180 80903 64654 14175 14173 14164 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 96%195258 RHO GTPase Effectors 232440 12387 12550 319149 22628 381293 76804 15077 17886 26416 26413 26417 67268 19094 54401 55948 12638 29875 19877 263803 11465 52428 20166 19878 18479 12704 18607 18481 11852 404710 13367 16594 103573 232943 320795 17978 109333 208846 16593 19354 20201 74764 20202 640703 11853 22627 50884 83767 329165 71893 12532 18762 11848 105855 242687 17969 237038 77579 11308 71960 224480 16885 13058 16886 241275 13057 108100 11461 17970 101314 17972 544963 100039786 16572 16573 16412 13385 16709 20430 192176 56419 12385 23988 67938 17904 107589 56212 17283 17880 76709 73178 12229 19046 56443 320271 99982 80987 68089 67771 11867 56378 66713 74117 13542 245880 13544 14083 18016 13543 76378 22376 100039683 215280 233406 68524 14026 17973 223701 330319 76884 18643 18645 12576 108911 73470 16563 75786 70454 216965 11350 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 73804 19053 22379 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 329251 13426 68458 52504 17931 13424 75669 228421 22342 225326 71409 57778 18751 11835 18753 15267 319168 319167 224105 319186 319178 319183 319182 20807 14270 319190 94221 13043 319176 319181 19353 14787 11854 12631 319169 22631 22629 625328 78303 18817 319188 15270 18750 624153 382522 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 96%2046106 alpha-linolenic acid (ALA) metabolism 11666 15488 113868 68801 54326 170789 56473 76267 54325 20280 12686 14081 TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation 21814 100042305 208117 59287 100039623 17387 17389 21858 21857 19164 19165 TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism 18747 14571 14079 19047 14080 75772 11770 23945 75497 16890 19045 12389 18749 21884 67469 19046 103968 66905 12140 16204 16592 14077 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) 16419 12491 13058 13057 17969 17970 17972 16410 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 96%177504 Retrograde neurotrophin signalling 18211 232910 11773 13430 54152 20404 11771 11772 103967 71770 67300 13429 12757 18049 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 332937 80707 106931 233107 21420 21419 226896 21418 22196 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-HSA-9006931.7 Signaling by Nuclear Receptors 233833 232440 20602 319149 268980 20779 16478 11651 12389 11652 15077 18710 12005 26413 26417 28200 17869 13649 21802 18176 15461 67484 218214 11815 320982 104263 18708 19014 18709 15516 18706 18607 328572 17395 21372 18127 17977 14462 103573 21374 17978 59035 81004 56310 268903 107951 15183 20185 218772 19411 12914 11909 235459 640703 83602 68263 228026 18604 236900 27273 12455 27402 16001 56484 16476 18597 18598 17863 235339 18762 20683 14732 20249 14697 13610 13382 14710 14699 66066 14700 14708 14706 14704 19060 14695 14693 64337 14709 14701 230674 20698 12705 14702 30924 14696 20148 19378 237320 13082 98711 11307 12903 56847 22259 19682 242285 105014 232174 11303 216454 546726 17252 14678 108841 14677 241452 14229 105349 218203 103968 67393 12648 14679 13033 99982 16204 14228 16592 18986 17979 193796 14688 228913 13207 21887 15375 55960 268527 107351 11812 26424 21786 11813 22282 22278 18519 11425 100041004 100043508 14083 68268 12904 12390 20315 17393 22236 102193 67738 242851 18534 22632 11816 12443 12576 15519 100039592 20183 20182 20842 24061 19357 12400 14104 17392 12223 16589 71920 13874 13712 15200 13006 11839 12043 13645 20843 68705 98053 66420 69833 67710 245841 69920 13983 20022 22260 20020 20181 231329 20021 69241 13982 17749 100043714 11668 19401 15267 319168 18667 319167 14281 76850 239528 319186 319178 319183 319182 20807 81601 236511 319190 14282 319176 319181 213988 11522 26876 217351 214150 17454 17390 319169 15469 67470 27409 625328 78303 319188 19015 15270 433759 624153 71393 23797 382522 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%1839124 FGFR1 mutant receptor activation 14389 80857 110279 14180 14177 64654 14175 14173 20851 14164 20850 75296 360013 432508 67529 13047 76007 14182 67384 20846 20848 244373 21848 18708 18706 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 12021 81601 327762 20422 269400 19361 114714 22427 11920 12189 12190 237911 57434 225182 74335 26909 12144 233826 19362 19360 17535 21975 19363 19364 27354 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes 26432 26433 210530 56401 76477 18542 234407 12817 12816 12815 24087 12814 21892 12831 12153 12813 94216 12830 373864 12821 107581 77018 12819 53867 12829 12828 12827 12826 12825 69700 12824 12822 71355 12841 12823 73368 12840 213945 12818 245026 140709 237759 12839 329941 12837 12836 12835 12834 12833 12843 12832 12842 18453 18452 19035 18451 320452 56693 269132 237360 14789 330119 12406 216725 18822 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection 18108 107305 72543 194309 14360 52348 116733 73711 22088 67123 330192 76959 66201 20479 66914 12504 100088 12774 19385 18107 12487 270627 68092 228980 319944 103573 21374 433702 20922 20833 216185 108143 18550 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 108664 21343 209361 226182 12454 229906 235459 24074 268373 83602 58202 68153 74197 67923 27224 27632 24116 12455 72949 13716 63856 56438 18148 66371 108138 94176 68953 75608 319583 18571 15162 12526 170762 140580 108989 231042 227699 208092 223921 227720 66700 269113 66679 18141 23825 107939 69482 71805 11739 433923 11740 54563 16646 19069 15361 70699 101739 72787 18226 218210 11771 105513 11772 71770 232910 11773 12767 16881 16211 19386 19384 445007 11840 69912 103468 234865 21762 22123 59015 19179 69736 19181 19182 23996 19184 110379 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 14156 26446 19172 19173 19175 19177 21402 26443 26444 19170 66413 68705 98053 667035 13871 22190 66420 69833 67710 59029 245841 69920 67089 20022 14885 70247 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 15007 12010 224105 11768 11769 108012 11764 107975 11765 11767 252903 19353 83814 22596 14375 75717 16818 DRUG RESISTANCE OF ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9700649 Drug resistance of ALK mutants 11682 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID 16151 12675 16150 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 96%187024 NGF-independant TRKA activation 18212 18211 11516 11517 11540 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling 327826 14172 80857 14170 14180 14177 64654 14175 18176 20662 14173 14164 15461 83379 107971 80903 19247 14186 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism 110446 71911 67041 64059 NUCLEOTIDE METABOLISM%REACTOME%R-HSA-15869.7 Nucleotide metabolism 57813 67464 108147 69719 12495 11564 11566 12496 12497 215446 14544 231327 237823 53893 67365 66358 72090 67725 75686 22247 66422 80914 320685 22245 93692 68556 18102 55936 76952 18103 20133 381101 20135 229363 66588 93685 78801 11565 51797 72269 21915 56749 11636 16434 22436 11637 67054 229949 14450 214254 635960 79059 56520 15452 54369 382985 68870 100042069 23917 14923 22171 21877 56045 50493 22166 64705 76654 72962 99586 103149 230718 268782 50773 103850 22271 12499 75894 18950 229665 109674 11717 105446 11534 11486 11821 66355 13178 27369 23959 CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 11910 100039316 22121 17168 216805 101142 230676 27103 100043876 270802 100043893 98402 100043423 268933 100042986 56032 20115 72124 67281 16210 71962 76846 216742 625646 319481 100040298 231659 68172 101148 100042740 277854 19951 252875 228775 70394 667618 100040970 267019 56040 67248 100040331 67941 27053 57294 11911 12611 242341 68775 140742 66508 76252 545987 11972 108664 66290 54170 11909 11964 52187 68576 110935 66096 11966 83409 100039636 74370 66335 68441 11973 12608 11974 13198 268706 74915 338375 245670 73834 114143 66237 230784 110379 27060 66144 667035 13665 67204 26905 56717 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 56716 100038991 68028 100043000 67891 100043295 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%140534 Ligand-dependent caspase activation 14103 17087 22030 12475 21933 225471 106759 14102 21898 71609 14082 22035 12370 19766 RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 96%8941856 RUNX3 regulates NOTCH signaling 270118 328572 12914 16449 19664 14534 18519 12399 18128 333639 103806 15205 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963896 HDL assembly 11303 18747 232345 11806 27801 18749 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters 233836 239606 53881 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism 18295 244757 72297 14595 17022 75612 56336 56386 108902 14264 70484 53374 16545 227327 231727 53625 54613 116847 50917 57370 53418 56375 76969 54371 56773 20444 20442 70893 20443 15212 15211 27047 12091 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 96%9937008 Mitochondrial mRNA modification 75619 227682 83485 94254 380773 66410 67440 72416 71989 101122 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins 16993 11689 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%156580 Phase II - Conjugation of compounds 71522 207182 56615 211666 66447 22021 70484 22022 117147 76263 22017 14863 107146 216558 233799 233801 272428 435528 69065 75475 13885 14872 17961 54486 94215 68252 72094 66054 58810 213012 14862 14630 394436 14865 394433 14866 22235 68312 71773 100042314 100727 14874 100559 14871 231396 68044 394434 68214 94284 552899 223337 242585 17960 13077 14859 14629 76491 56362 319655 20859 67768 242291 108645 20860 57344 23827 67883 67674 73671 238505 29859 11720 20887 232087 210009 14873 14598 269378 14854 18113 12846 22236 23887 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%R-HSA-3656535.3 TGFBR1 LBD Mutants in Cancer 21803 21812 21813 14225 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%9690406 Transcriptional regulation of testis differentiation 22431 26423 20682 14463 14180 50796 11705 19215 13363 22762 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-HSA-110313.3 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 22230 56791 59001 74153 19687 100038882 19718 69263 22224 19714 66979 244666 269523 71890 26447 56210 68026 216835 667035 22190 68098 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 80905 67967 217069 217365 27015 69745 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME DATABASE ID RELEASE 96%5336415 Uptake and function of diphtheria toxin 15200 50493 13629 15516 12527 15519 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702998 linifanib-resistant FLT3 mutants 14255 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 96%964739 N-glycan trimming and elongation in the cis-Golgi 242362 17155 17156 17308 230815 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 96%9014826 Interleukin-36 pathway 54450 107527 215257 215274 54448 69677 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 96%2160456 Phenylketonuria 18478 SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 96%1483191 Synthesis of PC 100434 213603 242259 70129 68682 64899 14245 99712 64898 236899 12651 237928 56018 99138 212862 12660 13026 76574 13001 106861 13000 18559 100039026 18618 12038 12647 11423 210992 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190377 FGFR2b ligand binding and activation 14181 72514 14178 67112 14174 14165 14173 14164 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9931269.1 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 269523 66413 667035 22190 59029 67089 70247 244373 60533 108099 226144 193670 54197 241113 70377 216440 66753 67819 116891 20338 21762 22123 105787 108079 19179 19079 19181 19182 108097 23996 19184 26440 19166 19167 19082 26441 26442 69077 66997 23997 UNCOATING OF THE HIV VIRION%REACTOME%R-HSA-162585.3 Uncoating of the HIV Virion 268373 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) 17001 14865 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 96%4793953 Defective B4GALT1 causes CDG-2d 14595 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 96%5099900 WNT5A-dependent internalization of FZD4 232910 11773 14366 13543 22418 11771 11772 18752 71770 67300 12757 18751 216869 18750 74325 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8939902.4 Regulation of RUNX2 expression and activity 56436 17463 57296 12020 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 27401 22190 59029 16656 67089 70247 107568 13982 14815 26379 22160 13395 12400 56424 19017 56637 12156 21762 22123 20846 19179 17702 19181 19182 23996 19184 75788 26440 19166 170826 19167 26441 26442 69077 66997 23997 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME DATABASE ID RELEASE 96%9636383 Prevention of phagosomal-lysosomal fusion 233405 271457 667035 22190 12721 19349 15239 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 96%194306 Neuropilin interactions with VEGF and VEGFR 14254 18187 16542 18186 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation 640703 69219 114886 18127 66427 18777 18108 12389 11651 68268 20751 18107 15519 TNF SIGNALING%REACTOME%R-HSA-75893.10 TNF signaling 22241 56480 11491 16150 16151 14694 66105 53376 667035 22190 26409 67384 21937 30941 22029 229603 22258 17164 268749 106025 21926 74256 263876 21929 76580 22195 24105 12370 19766 11797 22030 56424 56489 11796 11798 71648 100041766 71609 14082 66513 66724 68652 66552 76686 432940 20598 12675 52440 58994 18201 73218 216080 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing 110606 57295 640703 14272 208884 18777 18176 18582 15461 70178 226016 57437 19671 436004 16653 56327 216169 12048 18761 19092 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 96%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) 216848 22632 232232 20602 18129 20586 20230 18128 79221 107932 16364 270118 170787 66310 140858 19646 234366 213464 214162 56233 245688 208727 23808 12418 23942 16189 17192 16163 17132 14281 103806 229542 12151 328572 19763 21372 54383 13619 17283 333639 241915 14462 16190 12416 20851 20850 81004 20852 15185 19821 70315 15184 15183 116871 20185 18986 116870 12914 23871 494448 14534 18019 18519 30951 53314 19664 16476 433759 16191 50794 18987 15182 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190374 FGFR1c and Klotho ligand binding and activation 64654 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.3 SUMO is proteolytically processed 100043429 75826 223870 320213 20610 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 96%8877627 Vitamin E transport 50500 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9617828 FOXO-mediated transcription of cell cycle genes 16600 59092 54601 12575 17700 56458 17126 13197 17127 12452 12389 17128 15228 56484 19651 12576 12226 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation 70560 71984 224805 353172 70791 68915 230577 97541 226539 71807 69955 244141 71941 70120 381314 67417 102436 74776 85305 109093 212679 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9648895 Response of EIF2AK1 (HRI) to heme deficiency 17872 11911 14783 12608 13198 12611 15467 107503 228775 69065 13665 67204 26905 27053 11910 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 96%9930044 Nuclear RNA decay 72544 50911 69639 210106 72662 66446 227715 68092 24128 216578 664817 433702 112403 76014 225432 231386 67010 240255 70650 216345 50912 74213 214627 57316 72198 68533 77305 54196 83701 66362 109075 66583 27998 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 96%195399 VEGF binds to VEGFR leading to receptor dimerization 14205 14254 16542 22341 14257 22339 18654 22340 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 96%432142 Platelet sensitization by LDL 225849 26931 21770 26932 15170 18613 73699 18783 238055 14191 19052 19053 51792 26416 19247 226849 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME%R-HSA-9843970.1 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 319178 319183 319182 232440 319190 319149 110147 319176 74522 319181 15077 75339 67010 70650 223828 72198 319169 54343 625328 77683 15267 78303 319188 319168 15270 319167 84505 624153 319186 382522 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%372708 p130Cas linkage to MAPK signaling for integrins 109905 20779 54519 22371 14083 16399 14268 16416 12927 14161 21894 215449 12928 110135 99571 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion 74205 12491 50790 MEIOTIC RECOMBINATION%REACTOME%R-HSA-912446.7 Meiotic recombination 319178 319183 60530 17350 319182 232440 319190 319149 19361 114714 319176 12567 12566 319181 11920 15077 12189 12190 319152 225182 13404 26972 19183 12144 217716 381306 76915 68275 55993 17687 68240 19891 319169 213389 625328 78303 15267 319188 15270 319168 319167 19360 17535 624153 21975 319186 27354 382522 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME DATABASE ID RELEASE 96%9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 13001 100039026 12753 12568 11865 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin 14106 14313 66556 11481 17126 17127 16323 17128 16322 21814 269275 11479 83554 11480 16324 26413 26417 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 96%264876 Insulin processing 69940 16334 17918 245049 18453 66482 53413 11891 20336 107371 16572 16573 69048 57394 16574 18548 12876 105504 211446 22318 102058 239436 20907 18549 67475 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors 15566 15565 15563 15562 15560 15559 15552 15558 15551 15557 15550 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 96%9734779 Developmental Cell Lineages of the Integumentary System 11839 21802 13645 14165 19109 ECM PROTEOGLYCANS%REACTOME%R-HSA-3000178.6 ECM proteoglycans 13138 13406 12111 13004 16420 241226 17022 16398 14264 17182 16404 17967 18787 11603 66695 16412 17183 17180 21960 18198 16775 81877 16776 329278 16777 21923 666279 16779 12950 228357 226519 16411 16399 16416 12841 16772 12840 15891 16773 12845 16774 22370 12839 19280 15530 16419 16410 21803 21808 13003 20692 12032 104099 13179 21809 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters 68267 232333 14412 103098 216227 56774 104245 243616 13162 14664 140919 20518 240332 20517 22348 71803 74338 102680 20538 15567 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 96%5579000 Defective CYP1B1 causes Glaucoma 13078 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 96%8941237 Invadopodia formation 11490 11489 14218 11492 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654719 SHC-mediated cascade:FGFR4 14172 80857 14170 14180 14177 64654 14175 18176 20662 14173 14164 15461 83379 80903 14186 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%381070 IRE1alpha activates chaperones 225849 320209 56494 22393 16905 12282 15191 52639 72599 13191 192193 74322 71765 22642 28106 28146 231997 12751 56219 67398 228998 54616 52808 58193 105785 11370 11972 66515 20416 69162 100037258 74126 14583 11518 606496 21894 71853 20818 14828 107513 67838 68090 78943 381801 27362 50907 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI 68275 106344 72151 68240 19891 19687 19718 69263 19714 71890 26447 56210 667035 22190 18538 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73728 RNA Polymerase I Promoter Opening 319178 319183 319182 232440 319190 319149 319169 319176 21429 319181 15077 17191 625328 15267 78303 319188 319168 15270 319167 624153 26417 319186 382522 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%9006925 Intracellular signaling by second messengers 233833 13626 12326 268980 18183 83961 320207 100042150 20779 19084 17295 11651 11652 22324 18710 18754 52615 17999 19646 234366 26413 26417 14360 327826 13001 13000 100039026 56233 245688 13649 21802 23942 78757 228775 30955 18708 18709 18706 108083 18607 74769 18707 12487 12519 12524 19354 15183 66508 545987 54170 11909 640703 22084 52187 68576 66096 83409 74370 68441 268706 15234 67605 245670 56484 16476 83490 18596 216848 77647 18213 107932 19211 19712 18595 22059 229542 20613 56424 56212 19088 19108 11798 18718 104110 432530 99982 210044 217864 104111 13866 18720 18719 224129 11512 11513 11514 11515 15370 18749 19085 20393 12575 18854 66894 19087 72607 68031 73162 19720 21951 74493 14302 12322 12323 108058 12325 12576 14255 229709 16438 16439 21907 18747 100039592 16440 73699 12015 12371 12418 19052 17192 19053 51792 14013 12151 226849 225849 26931 19763 21770 26932 17246 54383 13619 55984 12223 241915 12416 71920 13874 15200 211323 19821 77125 494448 21762 30951 22123 12064 12675 14388 17082 19179 19181 18212 207565 19182 23996 18205 19184 78405 99377 18752 26440 18803 19166 11839 19167 13645 26441 80903 384783 26442 69077 14186 66997 14165 23997 14389 56436 16367 17463 14172 57296 80857 20422 26445 16334 14170 26446 19172 14180 19173 14178 19175 56458 14177 67112 19177 64654 14175 14174 26443 14173 26444 14164 83379 19170 17874 66413 16179 667035 22190 59029 13983 67089 70247 266632 13982 18753 110355 18575 18574 19016 18573 244650 13498 68877 98432 58988 15937 12478 75778 76850 239528 18591 54601 236511 56717 16337 13653 19353 213988 217351 56637 14256 214150 227743 15184 19247 22034 116871 116870 104709 20583 14056 18717 17454 252870 109270 606496 433759 16818 16590 56716 18750 15182 23797 54484 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 96%8982491 Glycogen metabolism 640703 13853 56043 77559 216558 72157 68961 18679 667035 105193 110094 22190 102093 232493 14936 74185 110078 27357 110095 18682 19309 14387 53412 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674403 Regorafenib-resistant PDGFR mutants 18595 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation 17248 26931 12534 50883 20393 228829 12428 17246 56717 11651 11652 67338 11920 12566 53376 667035 22190 13163 12142 227743 80751 12578 252870 12427 73699 109270 22059 12450 19052 78757 19053 51792 56716 23797 18607 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME%R-HSA-9937080.2 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 14178 13645 14175 14165 14173 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 96%70263 Gluconeogenesis 230163 14377 14385 18648 56012 226265 13806 18563 18663 14121 14120 21991 13808 74551 18655 13807 14447 68401 224674 14751 100043349 11676 18534 11674 14378 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades 233833 16451 12534 208884 18039 18183 14810 83961 11472 100042150 20779 23859 14814 17295 109880 216148 26413 26417 14360 29857 12988 20416 327826 109905 17869 20418 13649 19730 21802 54401 26395 194231 26396 54519 29875 18176 245684 20662 22371 16416 15461 75590 110157 231474 23980 18218 14161 63953 21894 13537 215449 19252 11836 240672 109689 216869 26403 72399 18708 18673 18709 16452 18479 110135 99571 18706 22330 16706 74769 18481 103573 14587 14586 19197 14588 19262 545987 640703 19419 83409 240168 15234 56484 16476 18188 18596 11876 56438 18582 56327 16184 16183 19713 545156 19060 13385 18595 70686 53310 13383 16453 54721 19046 17979 13866 110606 26554 226525 14272 18015 320484 211255 240057 101809 54153 114715 114716 19414 69601 19415 18749 14083 218397 114713 16188 16185 12984 12982 16192 16191 20739 20740 640524 20742 20741 20743 12445 12322 12323 108058 12325 16186 14255 17967 80297 320139 18747 56705 81489 19047 15507 73699 19052 19053 51792 19373 19374 226849 225849 17165 26931 14573 21770 26932 229776 12223 19417 19418 71920 13874 15200 211323 14585 16193 18777 21762 22123 14812 19179 19181 19182 70178 23996 226016 19184 107971 19671 436004 26440 216169 16653 19166 11839 19167 13645 12981 26441 12048 80903 384783 26442 69077 14186 66997 14165 23997 56436 16367 17463 14172 57296 80857 20422 26445 14170 26446 19172 14180 19173 14178 19175 56458 14177 67112 19177 64654 14175 14174 26443 14173 26444 14164 83379 19170 260409 66413 667035 22190 59029 16194 67089 70247 57295 104252 16399 14268 235584 67603 319520 58804 224105 19731 218294 76850 18611 239528 18591 140486 70727 21687 11600 18612 19732 17532 76089 236511 235072 171463 56392 67836 71746 225724 50772 19353 213988 217351 14256 214150 19247 18761 233046 17454 17169 57437 16590 19092 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 96%9769740 Coagulation pathway 19152 14066 217847 279028 14068 11905 15160 14058 14071 66901 18787 15529 11603 23888 20971 20969 14723 22371 16399 16416 71951 14161 20970 58992 16621 14735 12258 105722 14724 56744 110135 54368 99571 14729 15530 21824 14060 233246 109821 14062 20720 14061 268591 103978 19124 20597 68891 14733 74145 14067 385643 14734 19123 14069 19128 11820 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619483 Activation of AMPK downstream of NMDARs 207565 108097 640703 108099 19082 241113 105787 108079 19079 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 225849 26931 21770 12519 26932 12524 73699 17096 22612 11651 11652 19052 19053 51792 16818 19247 23797 14360 12477 226849 SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 96%1483226 Synthesis of PI 18739 74596 19679 327958 52858 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 96%5693537 Resolution of D-Loop Structures 12021 224008 60530 81601 327762 20422 269400 19361 114714 209334 22427 11920 12189 12190 237911 57434 225182 74335 26909 71711 12144 381306 233826 19362 268465 52864 19360 17535 21975 19363 19364 27354 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency 227095 INTEGRATION OF PROVIRUS%REACTOME%R-HSA-162592.5 Integration of provirus 23825 268373 319583 22596 14375 16646 15361 101739 108138 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS 20388 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190373.6 FGFR1c ligand binding and activation 21814 80857 67903 14180 14177 64654 14175 14173 14164 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels 242425 14702 14696 16514 16519 16520 54393 14697 16518 16516 14710 14699 66066 14700 16523 20927 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 20928 14693 16517 64337 14709 14701 56379 211480 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression 20459 14815 75273 15251 13819 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition 16785 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 100039316 20115 76846 100040298 13665 67204 267019 26905 67941 57294 75705 27207 67097 670832 13684 633683 20044 27050 208643 667279 20085 668144 20084 217869 382492 20055 75617 27370 629957 20102 20103 668668 667739 66481 225058 100038875 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 96%5654741 Signaling by FGFR3 14172 80857 14180 12402 24064 64654 17346 14175 14173 14164 109880 667035 22190 19247 26413 26417 327826 14425 18176 14388 20662 15461 19052 107971 19053 51792 18803 80903 18708 18706 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA 80911 15488 12908 17117 170789 74114 93732 74121 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9656255 Defective OGG1 Substrate Binding 18294 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism 18295 12111 121021 14043 13004 14042 15530 14595 13521 17022 72136 103978 269941 218271 14264 14733 53374 15529 11603 23888 16545 20971 20969 14734 116847 117592 71951 20970 29873 13003 56773 14735 23972 72727 15212 15211 27047 12032 13179 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade 16451 208884 18039 18183 14810 83961 11472 100042150 20779 23859 14814 17295 109880 216148 26413 26417 14360 29857 12988 20416 327826 109905 20418 13649 19730 21802 54401 26395 194231 26396 54519 29875 18176 245684 20662 22371 16416 15461 75590 110157 231474 23980 18218 14161 63953 21894 13537 215449 19252 11836 240672 109689 216869 26403 72399 18708 18673 18709 16452 110135 99571 18706 22330 16706 74769 14587 14586 19197 14588 19262 545987 640703 19419 83409 240168 15234 18188 18596 11876 56438 18582 56327 16184 16183 19713 19060 13385 18595 70686 53310 13383 16453 19046 13866 110606 26554 226525 14272 18015 320484 211255 240057 101809 54153 114715 114716 19414 69601 19415 14083 218397 114713 16188 16185 12984 12982 16192 16191 20739 20740 640524 20742 20741 20743 12322 12323 108058 12325 16186 14255 17967 80297 320139 56705 19047 73699 19052 19053 51792 226849 225849 26931 14573 21770 26932 12223 19417 19418 71920 13874 15200 211323 14585 18777 21762 22123 14812 19179 19181 19182 70178 23996 226016 19184 107971 19671 436004 26440 216169 16653 19166 11839 19167 13645 12981 26441 12048 80903 384783 26442 69077 14186 66997 14165 23997 56436 16367 17463 14172 57296 80857 20422 26445 14170 26446 19172 14180 19173 14178 19175 14177 67112 19177 64654 14175 14174 26443 14173 26444 14164 83379 19170 66413 667035 22190 59029 67089 70247 57295 16399 14268 235584 67603 319520 19731 18611 18591 70727 21687 11600 19732 17532 76089 171463 56392 67836 71746 14256 18761 233046 17169 57437 16590 19092 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%8868766 rRNA processing in the mitochondrion 68626 72181 52575 75619 227682 83485 94254 224481 66132 66410 67390 217038 15108 69821 71989 101122 68017 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%5357801 Programmed Cell Death 74568 12387 12550 211586 22628 13176 13555 20230 21781 11651 11652 74268 227753 72565 66593 26413 26417 15519 16211 54401 55948 12015 12371 19877 12369 68097 14453 11518 13169 18810 21981 22352 16362 56702 50709 14957 18107 50708 14958 17087 80838 12539 209456 72993 56455 13144 13368 69635 13347 13143 97165 107449 94275 107448 56369 22062 21898 12578 26419 21762 22123 19058 19179 19181 19182 23996 19184 26440 19166 12043 16906 19167 22627 26441 12048 26442 11789 69077 12125 66997 23997 14103 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21873 13511 26443 13510 26444 21872 27061 12367 19170 18772 109620 13512 66413 667035 22190 59029 67089 70247 269582 100039786 12261 18753 22059 66371 14939 14102 68953 16176 75608 12362 12368 14251 18571 12363 22195 22035 224105 50873 16396 208092 12370 66700 19766 11797 56532 670717 14252 16173 22030 108155 16363 56424 12475 21933 16646 67245 69146 225471 11796 106759 11798 12018 50701 22061 53378 105513 16175 12028 54722 434174 12122 71609 14082 18761 70415 74143 78514 223255 19057 56215 171543 74006 67013 14272 22631 22629 12169 14083 20848 11783 23797 20740 PKR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9833482 PKR-mediated signaling 12534 17973 20892 100038882 16150 23992 21357 16151 18148 193740 23806 19255 19106 100037258 73699 66369 22059 67781 22196 19052 19053 56417 51792 20698 13665 67204 26905 15512 226849 15482 56791 67513 67030 16201 26399 101831 104806 20617 71885 13211 14087 100040608 15481 237211 72775 14088 60534 12675 20846 228607 217069 20848 69928 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 96%210993 Tie2 Signaling 13449 11600 74769 11601 50915 11602 18176 20662 15461 14786 18708 19247 18709 18706 20416 21687 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%352238 Breakdown of the nuclear lamina 12368 16906 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 96%189085 Digestion of dietary carbohydrate 232714 81600 71884 11722 226413 100043686 58866 69983 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) 53859 353328 66824 229709 14360 16438 16439 18747 16440 17096 18176 15461 110157 18479 18607 328572 18481 12914 640703 19055 19056 18018 18019 21762 22123 19058 12675 108723 18021 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19698 19177 15896 21402 73086 16150 170786 26443 26444 16151 19170 12042 66413 26965 667035 22190 240354 59029 26409 67089 103583 70247 14127 18753 16176 224105 12370 234779 18034 20963 100041766 216150 66513 93765 66589 22034 66724 68652 56619 269328 332579 26888 56644 22200 381809 17312 56620 17474 22192 17829 18749 100039649 140474 224116 216080 17063 73732 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 75705 13684 208643 217869 226982 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 13665 67204 26905 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi 11937 11938 20338 14595 53313 54613 18129 18131 18128 18132 16848 18550 19719 20443 17305 19346 100042343 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 15107 97212 231086 11364 26922 93747 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors 56316 19128 14058 14071 19123 14068 66901 14456 14061 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665230 Drug resistance in ERBB2 KD mutants 13866 59079 12539 15519 THE NLRP3 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844456 The NLRP3 inflammasome 54483 15368 66824 216799 19697 18034 12362 18033 18439 22166 67955 19200 56338 55991 11820 15516 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 18717 227377 14159 18845 18186 18844 19353 18846 20130 21894 223881 243743 20346 14360 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) 74338 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME%R-HSA-9763198.2 Impaired BRCA2 binding to SEM1 (DSS1) 12190 20422 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 96%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 78893 69125 18983 13682 13681 52846 192119 231464 58184 75705 13684 208643 234594 218693 56057 12193 382035 53621 72068 232791 104625 228140 192170 239528 18458 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB 207565 100039592 12322 640703 12323 108058 12326 12325 55984 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 96%9010553 Regulation of expression of SLITs and ROBOs 622534 13138 238217 14852 16785 666669 16870 100040021 16871 67025 100043391 268902 326622 668182 241053 16876 432502 19989 76808 19899 100043184 19921 19934 100043755 16872 67031 319195 100043209 20562 68193 15399 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 68092 433702 192160 208643 67923 21762 22123 60365 19179 19181 19182 23996 19184 68134 26440 19166 19167 26441 192170 26442 19826 69077 66997 23997 66441 56436 17149 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70247 12830 19876 20563 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 268721 668668 667739 14853 16825 16392 672214 170822 66481 225058 71745 100038875 100038991 68028 225363 100043000 67891 17690 100043295 18458 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 96%9014843 Interleukin-33 signaling 77125 17082 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 96%380095 Tachykinin receptors bind tachykinins 21337 21333 21334 21336 21338 ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964540 Alanine metabolism 76282 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8931987 RUNX1 regulates estrogen receptor mediated transcription 12400 13982 12005 71393 14732 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 96%400508 Incretin synthesis, secretion, and inactivation 18508 66624 12387 14695 14526 21416 233081 66286 56529 18548 64337 14607 14463 16392 16846 12591 225642 236781 76687 13482 107221 69019 242851 14688 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 13629 68028 100043000 67891 100043295 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9679514 SARS-CoV-1 Genome Replication and Transcription 13207 22346 19645 67197 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 96%77042 Formation of editosomes by ADAR proteins 56417 110532 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 96%173599 Formation of the active cofactor, UDP-glucuronate 22235 242585 70484 216558 67883 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 96%9022702 MECP2 regulates transcription of neuronal ligands 13388 12918 433759 12064 20604 20466 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 18011 232232 13388 16449 240055 225164 20602 11487 54485 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 15213 56233 17869 15214 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 15205 19664 433759 15182 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants 110157 17532 109880 19047 19046 11836 56392 54401 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) 14702 14696 14675 14064 14062 14061 14697 14710 14699 14065 66066 26413 14700 26417 14688 14708 14673 14672 14706 14704 14695 14674 14676 14693 64337 14709 14682 14701 109689 216869 SARS-COV-2 INFECTION%REACTOME%R-HSA-9694516.9 SARS-CoV-2 Infection 71164 53618 16451 20448 56208 227619 66383 19089 67443 13200 208884 78610 22628 11651 12389 11652 269523 54401 55948 233870 378425 218978 218035 15516 18607 66357 269338 16172 18550 22365 80743 12914 28185 71586 230073 66641 71956 228607 12695 217069 224912 20817 56217 20815 77573 14609 22627 24088 21897 93687 257630 56480 54131 66397 171095 15006 69608 218811 99683 240095 667803 23881 27041 14991 77371 100039786 20334 20390 66371 68953 75608 12785 228545 170762 108989 231042 227699 208092 223921 227720 66700 269113 67197 66679 18141 107939 69482 71805 73158 54563 71732 19069 70699 72787 18226 218210 54721 105513 233405 20847 27207 15975 67097 670832 633683 13207 16171 20044 27050 667279 20085 668144 20084 382492 20055 75617 27370 629957 20102 20103 668668 667739 66481 225058 100038875 16785 216799 18186 19645 100038882 12330 15519 15529 100039316 23888 20971 100039592 19386 20969 20115 76846 100040298 71951 20970 14735 267019 445007 67941 57294 15530 50528 70008 171283 103978 14733 69912 103468 15977 14734 234865 12675 59015 69736 110379 75669 225326 107686 384091 666609 216766 16150 621705 21872 20595 16151 66603 53975 192656 276919 20641 16179 667035 20638 225913 22190 69731 432803 26409 67332 257632 11603 107607 101772 108960 22196 102566 404545 170743 15007 12010 170744 105722 382014 17195 320091 22031 56489 233246 20014 72512 54123 103963 243634 56637 69038 66513 93765 13135 66589 19247 22034 66724 68652 15170 15469 22631 103534 67075 57377 22629 27801 228136 20846 75965 70546 108687 14423 269181 214424 57437 328417 217664 606496 69035 67287 107895 80285 20446 52552 20444 671535 22346 20442 547253 80286 20443 17308 17158 68292 20440 23797 67569 16430 14376 20447 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9762293 Regulation of CDH11 gene transcription 59058 24136 15426 16201 56198 20683 20613 15227 77630 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling 59079 12539 56424 18183 83961 100042150 84092 12223 11651 13874 11652 15200 211323 19248 667035 22190 19253 67588 15519 13866 13649 75717 17179 13645 23797 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 96%3229121 Glycogen storage diseases 14377 14385 13853 68401 667035 105193 22190 232493 14936 74185 27357 14387 53412 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 96%166187 Mitochondrial Uncoupling 22229 22228 20523 74011 11739 22227 212933 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling 233833 18796 18797 14686 21415 18795 14681 12387 16842 18643 12322 16438 93840 16439 16440 20187 105782 66313 216869 106042 21414 21416 208846 19354 74325 640703 19055 19056 18018 21762 22123 19058 19179 19181 19182 23996 19184 75788 18752 26440 19166 19167 26441 26442 69077 170758 66997 23997 56436 17463 57296 20422 11848 26445 26446 19172 19173 56513 19175 19177 57265 26443 26444 19170 14697 66413 667035 22190 18751 14710 59029 14699 26409 66066 67089 14700 70247 22411 14708 14706 14704 14695 14693 64337 14709 22417 14701 76850 239528 14702 14696 236511 14367 14365 14362 14366 19353 22418 11771 14370 213988 11772 71770 217351 214150 14368 14369 14688 22408 232910 17454 11773 13542 13544 13543 67300 26563 26564 12757 22419 225600 18750 19091 19092 18587 18588 18099 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610785 GLI3 is processed to GLI3R by the proteasome 12234 93687 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 56637 667035 22190 59029 67089 70247 18747 21762 22123 14634 19179 18749 19181 19182 23996 19184 26440 19166 24069 19167 26441 26442 69077 66997 23997 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5619113.4 Defective SLC3A1 causes cystinuria (CSNU) 30962 20532 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654700 FRS-mediated FGFR2 signaling 327826 14172 80857 14180 14178 14177 67112 64654 14175 18176 14174 20662 14173 14164 15461 107971 80903 19247 14165 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 96%8955332 Carboxyterminal post-translational modifications of tubulin 74410 237930 238328 67534 74711 244071 101100 320244 625850 223723 271813 110012 66257 69737 226841 22152 76223 227613 319953 22153 22142 22146 67951 73710 100042651 545486 22147 22151 67269 330010 66648 69216 231093 70892 22143 102747 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660516 Synthesis of PIPs at the early endosome membrane 233315 225326 170749 67073 77116 103199 18711 268783 84095 18704 234729 101490 17772 269180 75669 234515 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME%R-HSA-5083627.3 Defective LARGE causes MDDGA6 and MDDGB6 108902 16795 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 96%9913351 Formation of the dystrophin-glycoprotein complex (DGC) 13138 15530 244431 13405 20650 13528 13527 20649 24051 20648 20391 24053 24052 16651 268534 20392 11603 22288 16775 16776 16777 16779 16780 226519 16782 16772 23928 16773 16774 13497 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) 64176 64051 20614 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 96%69278 Cell Cycle, Mitotic 52717 99152 56299 668450 29870 17187 12534 217653 100038822 26413 12545 59046 244329 59021 382030 67121 56205 21664 52432 76044 78658 71175 74549 66352 67181 52683 70231 16452 15516 328572 109145 17216 272551 17215 17217 17218 17219 103573 17220 78833 12544 69270 16906 22627 63955 22390 99412 72568 77805 12530 231506 12531 629959 54124 12532 20459 75660 23834 71988 56438 18969 18968 19075 19076 66371 68953 75608 14235 208092 66700 19088 105513 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 21973 56371 27401 16881 12448 12577 12576 108911 73470 16563 75786 18747 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 59125 218914 59126 12235 217718 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 12428 57294 56455 226747 17120 26951 100710 108000 229841 12237 12617 107995 72415 83815 12615 66570 319152 244495 208628 76707 67139 68014 83431 13589 100043858 67849 12580 69912 625534 12579 13006 12578 18472 67733 103468 66468 76464 66442 67629 235661 56430 12427 234865 56150 12442 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 71521 13426 52504 17931 13424 228421 20843 15366 66671 17420 12572 15267 319168 319167 100986 319186 319178 319183 319182 319190 230376 319176 69654 71648 17274 319181 75296 56637 219072 225659 76478 22367 71955 78177 64383 224640 319169 319965 105988 28135 50850 214444 100042651 76816 54130 625328 78303 319188 15270 381644 18750 624153 23797 382522 20873 68121 232440 78887 78798 319149 22628 225745 231123 11651 11652 15077 74360 238799 18536 66296 214552 19646 18541 116733 13001 13000 100039026 17869 71909 237222 30939 17096 17997 13548 22171 21877 13361 18005 73738 68475 53598 208518 100088 236266 12009 99100 103733 22154 98386 74470 104318 101565 16328 259279 14211 83922 171567 51885 68298 19348 215387 26370 76789 72083 71819 70099 101706 233276 103768 74237 22147 22151 19650 19651 17865 27373 22143 268930 53857 22152 227613 72119 22153 22142 22146 67951 73710 13726 22145 22059 71782 545486 238463 170762 108989 231042 227699 223921 227720 380664 269113 66679 18141 23825 107939 69482 71805 16475 54563 19069 70699 67141 72787 64899 18226 218210 50793 18392 72590 18393 30949 66634 14245 77011 26428 19046 72486 26429 12537 56452 77744 64898 71978 20135 15519 11350 16211 19384 219103 229776 50496 13559 104394 21762 22123 19179 19181 19182 67956 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 27214 17463 67177 57296 20422 26445 14156 26446 57441 19172 70024 19173 19175 19177 21402 26443 26444 19170 66413 26965 667035 22190 18751 59029 67089 103583 70247 22196 671392 69745 327762 59001 19687 19718 69263 231863 66979 18538 19324 381306 68275 106344 72151 18971 68240 18972 19891 18973 18974 74498 67967 20878 217232 56317 59008 18817 66156 433759 216080 56041 69957 448987 17222 75430 68612 52563 22194 76308 68999 52206 100039535 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope 76770 19143 72432 12333 67451 259277 16769 74176 19041 68668 76560 16939 20754 240633 13511 56460 13510 626834 18772 109620 18550 13512 18553 64058 227937 20765 70166 13706 12336 66203 317653 71529 69511 21816 20129 668304 66344 13507 16480 13506 13505 386463 99681 14027 12365 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764265 Regulation of CDH1 Expression and Function 233833 12388 232440 19089 12387 13200 13626 11735 12550 319149 20586 19645 20779 13858 15077 104836 13345 12330 20901 21417 60611 52615 16601 114142 19646 26413 26417 21418 13001 13000 100039026 17869 245688 18109 22160 16480 22330 16600 66357 53325 17246 66286 228839 18550 18553 69019 93759 93760 13430 21762 56529 22123 19179 19181 19182 67956 23996 19184 105837 26440 13017 19166 13016 19167 15220 26441 26442 69077 66997 23997 56436 17463 57296 20422 24136 26445 26446 20683 19172 19173 19175 15376 19177 26443 26444 22431 21423 19170 14694 75339 66413 192173 667035 22190 59029 18746 67089 76007 56805 21406 70247 21885 18554 15267 319168 319167 13040 13030 76850 239528 319186 12385 319178 319183 319182 66624 236511 20613 319190 330914 319176 319181 20014 213988 103963 217351 214150 69038 13135 99982 76687 228913 20583 14056 18717 17454 319169 57377 625328 78303 319188 15270 433759 217734 99011 15182 624153 16430 14376 382522 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation 22632 18508 232440 13626 319149 15077 66310 140858 66420 69833 67710 52615 15399 245841 69920 19646 20022 213464 20020 20181 231329 20021 69241 17749 245688 100043714 55982 23808 19401 15267 319168 104625 319167 13654 319186 22658 328572 319178 319183 319182 17268 15400 17344 319190 16475 231051 15412 16658 18514 15407 67278 15401 13018 319176 15423 329559 319181 15410 103889 18771 15436 15434 15394 15429 58184 15183 20185 17979 218772 19411 12914 56406 14056 319169 22289 625328 16476 78303 319188 15270 624153 381022 382522 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9609507 Protein localization 16922 71382 12908 66865 17117 66105 67528 13142 74114 110959 70503 18126 11430 228061 22333 224824 18634 15112 28200 56185 80911 71767 76263 13850 73078 12012 15925 111175 19193 93732 20280 51798 74043 171210 11611 212503 17527 65098 56794 19298 18416 15368 22284 11692 28146 30960 69617 103172 66826 27643 19122 19301 66531 66525 52815 56322 18632 433806 20524 100042179 66437 12328 17714 66433 66169 15929 56273 28185 100043869 67105 668173 21855 103737 18633 72129 30059 19302 71446 14356 30055 224727 68185 59038 56495 11429 74147 53333 171282 68033 11666 67604 26458 12856 15488 30057 113868 21856 170789 30056 26378 66119 15356 22318 100039174 14545 30058 66887 20907 66170 11820 223696 12974 52551 72170 17713 67713 67979 67892 636544 67264 74159 14297 667035 22190 19299 66821 100900 66445 56535 26874 13726 15510 12359 56389 11739 11740 100041766 100043039 17827 66212 68653 83762 71883 11947 66075 14712 11946 15526 15926 53375 100041835 216080 78830 50799 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane 20873 68121 12534 78887 22628 277939 225745 231123 654470 227613 67590 74360 22153 18536 22142 66296 214552 74201 18541 75786 15519 18747 67161 53869 71909 140810 237222 22145 17997 67978 18005 73738 68475 51792 53598 208518 380718 236266 100986 244585 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 77048 230376 260305 69654 52906 17274 83922 18000 216363 75296 26370 72140 76707 219072 13589 225659 18472 53885 76478 320299 329795 78177 27078 28135 214444 76816 217335 54130 232987 18817 381644 13427 22627 109242 13424 382090 232944 231214 27373 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME%R-HSA-5655799.4 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) 53945 15203 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 71519 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity 20602 22284 228839 83814 11545 66105 97064 667035 22190 93836 26413 20185 26417 67821 20482 20481 19042 94093 17126 17127 17128 66313 433759 216080 17131 21815 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition 18817 67141 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 96%381038 XBP1(S) activates chaperone genes 225849 320209 56494 16905 22393 12282 15191 52639 72599 13191 192193 74322 71765 22642 28106 28146 231997 12751 56219 228998 67398 54616 52808 11370 58193 105785 11972 66515 20416 69162 100037258 74126 14583 11518 606496 21894 71853 20818 107513 67838 68090 381801 27362 50907 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME%R-HSA-5657655.3 MGMT-mediated DNA damage reversal 17314 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%166662 Lectin pathway of complement activation 14134 17195 71693 239447 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 19128 14058 14071 19123 14068 66901 14456 14061 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation 16193 54721 16451 16194 26396 19247 16452 26413 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling 18053 18049 20598 DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 96%3359467 Defective MTRR causes HMAE 210009 238505 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 96%425561 Sodium Calcium exchangers 238384 317750 640703 20541 94249 170756 76376 110893 214111 110891 109552 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism 78038 243382 227095 11992 229517 72039 66885 56357 12035 12036 66948 107146 58875 104776 110446 12908 12040 12041 13171 13382 12039 15108 93747 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-HSA-418592.5 ADP signalling through P2Y purinoceptor 1 18441 14708 14672 14706 14702 14704 14696 14695 14676 14675 18783 14693 64337 14709 14697 14682 14701 26416 14710 14699 66066 14700 14688 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022854 Keratan sulfate biosynthesis 18295 72297 14595 17022 56336 56386 108902 14264 70484 53374 16545 227327 231727 53625 54613 116847 57370 53418 56375 76969 54371 56773 20444 20442 20443 27047 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 96%380612 Metabolism of serotonin 17161 11669 SELECTIVE AUTOPHAGY%REACTOME%R-HSA-9663891.5 Selective autophagy 22241 56480 67443 21821 67526 11793 100756 68146 66734 72018 269523 17966 19305 66105 245860 667035 22190 22334 22333 18541 15499 22335 15519 13001 13000 234663 100039026 12638 11520 26369 68097 57320 22195 108099 50873 56455 241113 71648 11920 18412 15185 100041766 66905 66410 93765 66589 13819 15481 66169 28185 100043869 235661 108079 19079 53333 108097 66119 13427 67414 19082 13426 170731 223696 13424 68943 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 96%597592 Post-translational protein modification 270160 17342 56208 19823 22201 19328 22209 12663 53323 70620 330369 66853 140499 50788 22213 67128 12640 22214 101206 67615 268470 230903 66772 208372 76454 15925 65247 65255 84585 15381 142687 78910 109331 231380 65256 12848 70392 216233 12700 225055 232539 100043806 26891 231670 56444 67665 69754 22428 77113 12344 207952 59288 320118 30843 18550 68854 76294 21812 21813 72323 399566 214931 28185 68441 13016 11789 66397 69608 218811 99683 192156 56453 77371 20334 13436 13435 13433 217365 15387 22195 50873 19766 11797 22230 22030 108155 18970 11796 14827 73582 68137 99375 22210 72584 58186 13194 67561 67711 76843 66341 26885 109113 223701 100040573 67241 66647 67872 65973 216799 67040 320213 20230 56459 72607 50995 68031 55989 73162 68501 19720 226026 21951 17190 74493 75826 223870 224903 21973 21974 21969 12418 29817 12151 17248 19763 14799 12428 17246 54383 13619 241915 12416 75221 68350 19821 224111 12578 16193 12427 18195 30951 11839 13629 11487 192656 24110 257632 12266 625018 107607 231130 76768 59025 26374 69654 17274 11843 103534 57377 100042651 54130 108687 19341 269181 66940 208659 217664 77407 13602 19337 16007 107895 20446 16011 20444 16010 20442 246228 20443 235442 13801 17308 12653 17158 11698 20440 20254 67569 19338 56047 14376 19672 20447 94111 13406 53618 30060 20448 15464 227619 11704 19089 71421 19326 217847 107338 77583 105348 80752 16852 18220 15160 20856 66848 338366 83554 11576 66557 98170 17182 16425 232146 12155 76453 74761 12419 21849 53869 21802 74126 67731 100683 218214 21825 53598 214669 104318 101565 12702 14462 26370 15258 14534 66967 223455 66597 108123 320011 108124 23802 22644 66435 76332 75841 16834 270192 319642 102339 19346 338337 216848 17957 67542 56382 69834 97484 233824 12662 18148 53376 19211 18619 22658 17283 16866 13207 12343 12345 18519 12340 21857 20739 268977 20740 22632 20750 14479 11733 11735 18854 640524 56207 20742 20741 84092 20743 110616 11816 66105 80297 17125 17126 17127 17128 66313 19339 17131 22284 56456 22224 56505 225280 242362 26893 56249 69714 227195 109275 26894 68142 108679 233875 70020 19358 19359 235134 22591 107986 26572 21762 432940 22123 26895 19179 19181 19182 23996 19184 19671 436004 26440 19166 18035 19167 26441 26442 69077 66997 23997 69260 12234 56436 17463 57296 20422 26445 16334 26446 223499 19172 19173 19175 19697 19177 21402 26443 26444 16151 19170 12042 66413 26965 667035 22190 59029 26409 67089 68251 103583 20184 70247 269582 22260 20181 70681 22337 70238 19013 27223 56469 19365 13982 22025 107976 19883 210766 11835 18227 14815 59004 20610 208727 19016 22196 71974 100043429 621893 110784 26423 319162 19401 319173 229615 319163 21834 18667 22027 12021 235505 56187 12321 54601 19352 22427 20255 19090 16009 16006 12189 80718 104009 70945 67091 18538 20703 11625 66226 19324 12144 105522 243819 68275 14067 69162 14275 12793 67857 100042773 233826 20333 252870 215474 207352 74498 212712 66682 52036 76983 13032 245828 20878 12794 20466 240667 67727 214895 59005 14069 78232 216080 56041 75396 333883 21787 27096 67269 68612 72978 11804 330010 227648 66648 15182 22194 76308 69216 71393 76510 231093 100042343 70892 100039535 50907 110962 102747 193813 15161 74410 12068 75302 237930 317717 68837 238328 12534 56494 22223 67534 60409 50933 74711 89867 17425 244071 20602 235416 71599 101100 216131 228790 320244 67231 625850 66890 223723 56324 271813 110012 15239 66257 69737 226841 20844 76223 319953 12005 240087 59021 224139 56233 21420 21419 14161 207958 71853 109689 216869 99571 328572 22393 11806 13191 192193 17977 238055 19017 17978 105785 18024 268903 12914 18002 100043869 640703 12870 22041 11820 99412 12530 71902 11555 56438 100756 13171 67295 19329 170711 330908 80883 212518 54644 72434 97884 14276 70527 380959 110826 224624 74270 76630 71472 66124 69908 56447 104416 54161 83563 76338 225896 66889 21684 30941 74112 108138 246190 229603 216825 22258 414084 433931 226422 74256 329777 320772 21929 67196 109979 27392 109978 269295 14731 12836 11889 11890 59007 54198 70325 59042 12182 14232 68453 246103 69641 68468 100102 76877 58222 276846 239706 244682 56395 18453 18700 67292 320204 11647 110417 71897 66113 11650 18701 80294 18488 67556 17068 21683 11657 71003 11807 79464 68043 66913 67133 56748 14756 59040 26554 71954 239827 327942 55981 98388 211255 237847 21838 235106 19335 50797 19342 19336 70349 12847 70163 67843 67164 241062 68133 13003 215494 228366 19334 235323 320840 246179 272411 70574 231050 19331 78754 114654 333424 16588 210004 74996 12091 108760 217371 11881 71685 319651 26887 76942 14426 54160 108148 224836 171212 105450 232984 228812 12575 108105 64931 241391 360216 14595 207839 107260 233733 66111 15275 108150 170745 212996 74762 97440 54399 654821 18793 72077 217615 50935 271786 19332 14537 328778 67909 68311 108902 22217 68149 230801 68404 27401 207965 13163 74653 170707 235441 22334 26434 68947 22333 57783 73068 268890 22335 226418 15529 216395 75847 72585 234663 23934 242681 109359 217057 19386 109154 14422 53614 54613 213827 11799 327799 52276 11844 53334 22242 19340 20842 72096 68097 69363 16319 72084 70511 217364 67511 668145 20877 56358 72373 24061 76486 76800 234700 70675 56703 445007 19376 19357 53868 57256 232973 30940 56746 243853 140703 623661 12159 78928 56455 66459 171167 71665 67099 22225 19244 56336 320713 56386 70316 75985 107995 235504 68366 20585 69912 76246 108089 13006 214498 19325 225131 68328 56273 103468 66317 668173 103737 68365 72129 231727 19302 235661 235497 14734 66510 234865 22083 268281 109815 233900 320311 59015 54624 69736 57370 53418 56375 17069 110379 13427 19128 268510 13426 13424 14456 20843 17309 11891 227327 53625 21923 14148 15267 319168 14118 319167 382014 56737 319186 320438 208624 319178 102580 319183 24070 319182 208211 193670 381903 54197 13478 328370 319190 26754 22031 56489 319176 18034 216440 319181 20014 103963 69038 13135 13819 116870 67819 106021 20687 116891 15248 26927 20338 319169 67075 14423 78303 319188 80286 68292 16430 382522 13200 72297 381677 269523 24108 102323 54638 140858 12558 100737 73828 66199 56468 52615 230796 415115 80913 213464 27784 114893 54607 99311 71991 28199 74106 78309 17869 76863 245688 240263 66498 52245 98193 434130 17846 15251 320808 12638 79043 66200 14155 53417 76501 242418 57320 69456 59043 14154 12238 68842 12006 66398 75763 233805 234664 74251 66357 216185 67923 19123 71586 230073 71956 228607 217069 22147 19345 271457 19344 22151 106052 242960 30838 235339 22143 11848 30050 50762 11905 22152 227613 13010 22153 50754 22142 11461 22146 19349 17304 56418 67951 70361 71833 213980 66251 73710 68628 22059 50789 545486 30839 16709 170762 108989 231042 227699 223921 227720 269113 66679 18141 56389 107939 69482 71805 54563 19069 70699 72787 18226 218210 108153 23794 30806 108154 16795 210417 271127 229595 208936 77739 381694 269959 667279 14425 269328 230145 110119 100689 11842 69080 233744 331026 235130 29858 240322 54128 20357 11504 20356 17829 21803 18636 100039649 21826 667739 140474 224116 226866 217734 170822 17063 59048 71745 240913 100038875 223838 99011 225363 237360 330119 216725 73732 13138 66548 330267 207596 224697 56229 353328 239337 68273 77794 94192 12317 279028 11545 12330 14314 67311 665189 225742 236082 107652 26938 20451 19703 245847 227697 20445 19106 20449 100037258 54342 19025 50798 66174 57357 50877 56174 14583 13480 14584 234730 13481 22122 241230 75540 228368 66248 24060 240119 218138 20454 109785 52014 12764 20450 66789 57170 69064 94181 74091 68563 67422 20452 18010 241159 23956 216197 14061 26464 22361 18412 77125 11840 15481 385643 64138 108645 78920 72345 64654 14068 71952 66632 13495 102115 58911 63828 107817 22021 276770 271970 56316 14058 69082 14071 67902 66901 22022 69740 13494 194952 545260 117589 269955 78541 57295 69299 238024 11883 77035 233902 67014 67228 66521 105638 50760 99349 74008 16777 235320 77041 16779 242521 270086 209239 208691 226519 74492 330817 14268 67728 66799 116905 72194 15204 77038 69706 15007 217194 226541 65257 242785 69666 16912 19171 211949 107047 66537 233040 19185 231672 19192 73902 66998 56088 231863 67151 101358 53380 12449 66506 224023 16913 109161 228769 22193 103554 71538 19186 228998 19188 67455 100041766 14794 216150 217217 66513 71999 93765 269529 17155 83962 17156 230654 230815 22034 635668 66515 269514 78889 68431 230904 71865 380928 50868 207215 72433 22200 627648 75717 106572 67921 22192 67790 142688 243574 216344 67844 433759 74646 448987 22346 12977 319189 228003 19330 212919 20439 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination 64658 66419 64660 78523 94061 623346 102060 50529 100040519 68565 99045 66973 69163 52443 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 67681 108853 64655 211253 107733 320806 68537 17721 18100 17722 67707 17716 94066 17717 60441 17718 218506 17719 66230 17720 68463 67871 65111 74600 107734 66242 28028 68735 622268 27398 94067 67840 68836 79044 94065 57312 75398 68572 67308 64659 56282 66292 24030 66121 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 17711 17708 17709 17710 17705 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses 328572 12914 16451 19106 15977 54131 67923 71586 75717 230073 56438 228607 217069 54721 20847 667035 22190 15975 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1483206 Glycerophospholipid biosynthesis 114874 28169 68262 66659 18806 55979 225010 18778 14792 329502 66857 271844 67452 237625 66853 665270 270084 53357 67216 68255 232889 225845 13001 13000 100039026 104759 97212 231086 12038 12647 11423 66826 99712 236899 12651 237928 79196 56018 237542 212862 28042 12660 70568 13026 85031 76574 74182 106861 105501 18559 27281 18618 102278 67078 71760 74451 12891 75320 66461 68671 218121 226856 245532 320951 66586 668257 192654 74486 56305 116939 66727 266692 110911 100434 213603 242259 70129 68682 19210 27388 14732 18805 76768 18783 69923 23945 64899 18739 215456 74596 14245 19679 327958 52858 64898 13350 18807 99138 67800 14571 77582 67512 14712 18779 239759 26971 333433 108958 99010 210992 14555 26970 26565 215708 102247 18784 18782 78390 66350 231510 52123 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential 52150 16525 16530 16515 16526 16527 223604 16520 74571 16518 217826 16529 211480 210741 332396 241769 72258 16528 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks 100039592 81601 19360 17535 27354 11920 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic 270160 17957 56389 67542 56494 242406 228960 76877 97484 54399 233824 75985 11650 109181 22365 17155 17156 13047 230815 11840 56418 18195 108123 53334 108124 76332 16834 226089 53611 102339 19157 67474 19159 58244 17158 19158 72318 27277 338337 19338 73124 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 96%73943 Reversal of alkylation damage by DNA dioxygenases 268420 69113 69090 75452 77987 231642 26383 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling 15200 211323 18183 83961 18708 100042150 12223 18706 13874 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 96%9861559 PDH complex synthesizes acetyl-CoA from PYR 27402 18597 18598 13382 68263 235339 SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.5 Surfactant metabolism 18442 20390 20387 12945 224792 216197 52713 16541 14465 30937 70546 13036 27410 12984 12982 22130 20389 11551 20388 11541 11553 11540 20505 20531 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) 15932 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects 12571 12567 12578 MATURATION OF REPLICASE PROTEINS%REACTOME%R-HSA-9694301.5 Maturation of replicase proteins 66383 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9603798 Class I peroxisomal membrane protein import 67979 56273 103737 56535 72129 26874 18633 19302 74159 74043 59038 11666 19301 19298 14545 18632 20524 19299 66437 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME%R-HSA-9726842.2 Gain-of-function MRAS complexes activate RAF signaling 110157 17532 109880 19047 19046 11836 56392 54401 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022923 DS-GAG biosynthesis 77590 12111 29873 212898 121021 13003 338362 13004 319901 12032 13179 72136 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma 15129 93671 15122 16971 11806 11657 11699 15458 15439 16069 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 96%109606 Intrinsic Pathway for Apoptosis 211586 13555 22628 21781 11651 11652 12367 74268 72565 66593 26413 26417 100039786 12261 54401 55948 12015 22059 12371 14939 12369 68097 21981 18107 12370 670717 209456 56455 69146 11798 12018 22061 56369 22062 12028 54722 12122 19057 171543 12578 26419 22631 19058 22629 20848 11783 12043 22627 12048 12125 23797 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 75705 13685 13684 208643 217869 226982 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 13665 67204 108067 217715 26905 13667 209354 224045 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 18458 DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9920951 Dengue virus modulates apoptosis 216965 56208 225326 109270 74370 56717 78757 18035 13163 227743 18036 56716 218978 66270 75669 19766 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811434 COPI-dependent Golgi-to-ER retrograde traffic 17957 26934 54160 74947 16570 107338 66111 240641 269152 16565 16564 16552 16580 16581 67023 16561 16562 72772 16558 70218 73470 20932 16563 75050 16554 286942 16568 71116 16578 319991 16572 66251 224630 16573 16560 56447 54161 213827 11844 73804 67511 77038 56358 59042 26951 16594 229841 668303 16579 232943 19348 228998 71819 68137 16593 105785 16551 110033 11843 209737 11840 74764 19324 66913 100042773 20333 11842 16569 50797 18195 108123 108124 70349 16571 12847 76308 228421 100042343 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins 235281 20266 20265 11733 11735 640524 20742 20741 319504 20743 20271 399548 20272 20274 20273 110876 20269 72821 110880 269116 80297 20264 24046 16728 16536 110862 20739 20740 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 14609 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380320 Recruitment of NuMA to mitotic centrosomes 20873 68121 12534 78887 22628 225745 231123 227613 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 259279 83922 171567 51885 75296 26370 76789 72083 101706 76707 233276 103768 74237 219072 13589 225659 18472 76478 78177 28135 214444 76816 54130 18817 381644 13427 22627 13424 27373 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels 52150 74571 16525 217826 16530 16526 16527 332396 72258 223604 16528 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 96%5693538 Homology Directed Repair 70620 12566 11545 16881 240087 11350 50721 19822 12428 319152 11546 13870 12427 50505 20422 14156 667035 22190 107823 68251 20184 66131 269582 232314 70681 70238 27223 19365 56420 107976 210766 21853 59004 22196 100043429 15204 52864 19360 27015 69745 17535 21975 77782 19363 319186 19364 27354 319178 12021 319183 224008 319182 60530 81601 327762 269400 59001 319190 19361 22594 114714 16882 209334 22427 19687 19718 69263 15574 11920 319181 66979 12189 12190 235610 231724 237911 19355 57434 225182 74335 93765 26909 18538 235559 71711 12144 381306 68275 106344 72151 18971 68240 18972 233826 19891 18973 18974 80905 19367 19356 19362 67967 268465 12649 78303 319188 15270 382522 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism 110821 66904 17850 73724 109136 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation 15234 17295 MATURATION OF HRSV A PROTEINS%REACTOME DATABASE ID RELEASE 96%9828806 Maturation of hRSV A proteins 13001 16211 13000 100039026 66624 19047 66286 56529 19045 103573 18550 19046 76687 69019 PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 107995 12534 18817 56371 67141 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery 20922 20833 68705 98053 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 20020 231329 12454 20021 69241 17749 100043714 58202 67923 27224 27632 20924 24116 12455 72949 13716 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production 14694 21926 20598 21937 58994 18201 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8963693 Aspartate and asparagine metabolism 104816 14719 78830 14718 11484 50799 269642 73748 72560 27053 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 328572 12843 20683 211586 17283 21781 228839 18550 16477 97064 667035 22190 107951 93836 26413 18787 26417 12579 22608 13559 12454 104394 51813 17869 17126 17127 12455 17128 72949 433759 17131 19650 21815 264064 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation 16193 54721 16451 12534 26395 16194 19247 16452 26417 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 96%442982 Ras activation upon Ca2+ influx through NMDA receptor 640703 13385 18039 14810 53310 11472 13383 23859 19417 14812 18176 14814 19418 15461 12322 12323 108058 12325 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 12567 12578 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere 68275 18971 327762 68240 18972 14156 19891 22427 57321 67967 28113 101185 16881 21749 497652 21750 69745 18538 12144 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation 22260 232910 11773 100102 22259 11771 11772 71770 67300 667035 22190 12757 218203 22359 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis 17913 246256 17973 17909 105855 242687 330319 76884 22612 11308 22324 17886 108100 12928 11461 101314 26413 26417 14360 22325 11350 12502 57257 140579 17096 330662 11465 15162 140580 20430 17918 76709 19353 73178 20963 12229 56443 80987 68089 67771 11867 56378 66713 74117 245880 14191 14083 22376 215280 68524 50884 17925 83767 17882 329165 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 96%9665233 Resistance of ERBB2 KD mutants to trastuzumab 13866 59079 12539 15519 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs 16993 17001 15446 11684 13850 13106 11687 72303 13077 56448 13076 13114 19225 11689 14865 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 96%9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 13138 20665 18992 18991 20586 17936 17937 97064 13121 20788 215798 15357 110789 17528 22288 19153 22601 17196 16777 18858 226519 16773 21676 13497 13654 15182 17136 SIGNALING BY ALK%REACTOME%R-HSA-201556.5 Signaling by ALK 328572 74769 16367 19283 11682 16453 16186 12142 15183 327826 15170 17869 13433 15251 620393 20466 18109 19242 20848 433759 18803 60533 17242 18708 15182 18709 18706 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles 23825 15361 101739 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%73854 RNA Polymerase I Promoter Clearance 216848 232440 319149 667501 107932 21429 20019 15077 21340 17191 21339 21341 64424 22130 13871 75316 66420 70333 69833 66136 245841 20017 19646 234366 26417 14885 209357 66467 66671 17749 245688 100043714 17420 12572 13872 23894 14884 23942 17192 15267 319168 319167 229542 319186 319178 319183 319182 319190 319955 106298 110147 319176 21374 319181 116871 116870 20018 14534 20016 319169 18519 12417 625328 78303 319188 15270 433759 15182 624153 382522 CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 96%5607764 CLEC7A (Dectin-1) signaling 12234 56436 53859 17463 57296 20422 26445 26446 66824 19172 19173 19175 19697 19698 19177 21402 16150 26443 26444 16151 19170 12042 66413 26965 667035 22190 240354 59029 26409 67089 229709 103583 16438 70247 16439 16440 18753 16176 12370 18607 234779 18034 20963 100041766 216150 66513 93765 66589 22034 66724 68652 640703 332579 19055 19056 56644 22200 18018 18019 21762 22123 19058 12675 108723 18021 19179 22192 19181 19182 23996 19184 18033 26440 19166 216080 18035 19167 26441 26442 69077 66997 23997 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 96%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 13361 640703 19286 18127 20751 19092 11651 320415 15519 14528 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%9022692 Regulation of MECP2 expression and activity 233833 98386 20602 236511 12326 21372 15228 213988 81004 12322 12323 217351 108058 12325 214150 56310 15183 20185 15258 18747 640703 17454 20466 433759 20877 15182 76850 239528 15194 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway 26399 11796 16150 16151 192656 16179 26416 66513 93765 66589 26409 22034 257632 29857 66724 68652 19094 107607 332579 26415 12371 12675 108960 12366 12362 74256 12363 21929 16396 12370 227290 11797 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020958 Interleukin-21 signaling 20850 20848 16451 60505 60504 16186 20849 20846 16453 20851 COBALAMIN (CBL) METABOLISM%REACTOME%R-HSA-9759218.2 Cobalamin (Cbl) metabolism 77697 109129 210009 67096 17850 109136 238505 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses 16451 56208 216799 100038882 15519 100039592 19386 378425 218978 15516 445007 16172 69912 12914 28185 103468 15977 234865 71586 230073 66641 12675 71956 228607 59015 217069 69736 110379 24088 21897 75669 257630 56480 54131 225326 66397 171095 16150 15006 69608 218811 16151 99683 192656 240095 667803 16179 23881 225913 26409 27041 14991 257632 77371 20334 107607 20390 108960 12785 170743 15007 170762 12010 108989 170744 231042 227699 223921 227720 269113 66679 18141 107939 17195 69482 71805 73158 54563 22031 56489 19069 70699 72787 18226 218210 54721 72512 54123 20847 66513 93765 66589 19247 22034 15975 66724 68652 16171 15170 20846 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate 227697 192156 67422 57357 52014 236082 57170 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-HSA-5607763.3 CLEC7A (Dectin-1) induces NFAT activation 640703 19055 19056 16440 18018 18019 19058 229709 16438 16439 18021 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels 242425 14702 14696 16519 16520 54393 14697 16518 16516 14710 14699 66066 14700 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 14693 16517 64337 14709 14701 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 96%69002 DNA Replication Pre-Initiation 52717 99152 668450 232440 319149 12566 15077 56371 12545 16211 17216 17215 17217 17218 17219 17220 12544 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 56436 27214 17463 67177 57296 23834 20422 26445 26446 57441 19172 70024 19173 19175 16650 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 18969 18968 19075 19076 15267 319168 319167 319186 319178 319183 319182 59001 319190 16646 319176 319181 66979 50793 18392 18393 66634 26428 26429 56452 68275 68240 19891 18973 319169 18974 217232 56317 625328 59008 78303 319188 66156 15270 216080 69957 17222 75430 68612 52563 624153 22194 68999 52206 100039535 382522 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 14172 80857 14180 14184 80903 64654 14175 14173 14164 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 13543 68339 13542 13544 CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli 15901 67443 15516 13007 104069 56444 67665 22428 12344 59288 66508 545987 54170 52187 68576 66096 83409 74370 68441 268706 67605 245670 67838 270669 12282 20683 18044 18045 18046 17969 13058 13057 17970 17972 17764 56453 217365 213539 670717 22230 56445 19088 104110 16175 432530 210044 104111 224129 11512 11513 11514 11515 15526 18439 19085 216799 12322 12323 108058 12325 18747 110651 20112 12418 15364 665113 28113 77683 101185 15260 22166 29817 75560 56702 50709 14957 50708 14958 20657 12151 14630 26408 76408 17248 66401 17165 14780 19763 14778 80838 14775 66403 26462 12428 67305 17246 12460 54383 11833 13619 11911 110147 26399 11927 57321 20293 26400 69590 241915 76650 12416 17436 26398 75221 26420 50527 26414 14950 26397 17134 13875 27407 319152 75512 104248 68350 19821 18104 21749 11758 497652 14859 21750 11757 23939 140742 100043858 224111 12580 109778 216850 233016 12579 71389 12578 106766 16193 667310 23872 14629 23871 50932 26921 494448 15977 26419 12427 170644 12608 30951 11839 12043 18590 13645 12048 12562 18759 13665 67204 26905 15512 15482 16905 50758 69654 226641 101543 112407 112406 29806 319594 26570 54130 74126 50493 53598 18127 14776 12857 110323 12861 12862 12868 66142 12866 12865 100041785 333182 15510 19246 380975 17684 70640 17992 50490 14229 14228 12343 12345 12340 100043508 17387 64384 20750 17872 66105 12955 15499 72630 11350 56354 50497 17168 12017 216805 81489 101142 70356 230676 67669 27103 219158 270802 29810 98402 18415 268933 110920 56032 67384 72124 66538 16210 70369 71962 23950 216742 15525 319481 15505 231659 68196 101148 22791 277854 80888 252875 73442 70394 69065 12293 12295 12296 12297 12858 21762 13198 22123 12675 19179 19181 19182 23996 19184 18033 230784 26440 19166 18035 20463 19167 26441 26442 69077 66997 23997 12234 14381 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 15467 21402 107503 16150 26443 26444 16151 19170 66413 26965 667035 22190 59029 67089 70247 17708 20181 17709 17710 19013 13982 19883 11835 18753 14815 110784 16402 18667 19360 56338 17535 22027 12359 84682 27354 81601 18613 14783 11920 16006 12189 15185 11863 68275 67013 69162 68240 233826 19891 20466 217232 56317 59008 66156 216080 69957 17222 22339 75430 68612 52563 22194 68999 52206 100039535 50907 52717 99152 668450 56494 12387 20602 20867 26416 26413 26417 20416 19094 102626 16416 17164 11518 21894 71853 20818 107513 68090 78943 19014 77128 229003 26427 11865 208647 19377 381801 70804 27362 52466 22330 27053 328572 12915 15129 320209 17087 78284 15368 64209 15122 22393 12013 15191 21372 52639 109151 72599 11806 13191 56760 192193 17977 74322 238055 12611 19017 71765 18143 22642 103573 28106 17135 28146 17978 75766 59035 109333 231997 81004 12751 66993 56219 17260 67398 17261 12913 21898 52808 12753 242341 105785 18024 68775 268903 70461 15369 15183 20185 76252 93759 11972 217166 108664 74343 66290 12914 382056 56406 11909 640703 11964 26357 110935 11966 100039636 66335 11973 11974 74915 12334 338375 12336 20656 73834 56484 16476 114143 69543 66237 18477 21672 16542 16906 22627 27060 66144 20459 18128 56438 14697 13856 230099 54598 14710 14699 66066 14700 14708 14706 14704 14695 14693 64337 14709 14701 54409 11535 14702 14696 18453 81904 11657 14688 26554 208677 18749 15926 12575 211586 13555 19645 21781 12571 12567 12566 13557 12447 242705 56371 27401 12448 12034 12576 66592 27377 234663 19386 73699 68097 19052 51792 445007 225849 57294 56455 15530 54616 56551 58193 69912 103468 235661 234865 59015 69736 21351 110379 13427 14828 13426 13424 21881 17250 110208 11977 15267 66839 319168 64704 58233 319167 15502 14281 18181 74142 76850 319186 319178 319183 319182 236511 319190 56489 56717 319176 319181 213988 217351 56637 214150 227743 13819 14056 17454 319169 109270 108079 20846 20848 625328 78303 606496 319188 15270 14257 56716 624153 23797 382522 233833 232440 13626 319149 13666 19084 11651 11652 15077 269523 52615 19646 14360 11910 13001 13000 100039026 17869 245688 22601 15251 53417 78757 17752 228775 17748 17750 17751 18709 66362 109075 18706 66583 18607 27998 74769 72544 18707 50911 69639 72662 66446 227715 74108 67923 14609 14672 16412 22059 628438 14682 170762 108989 231042 227699 223921 227720 269113 66679 58226 18141 107939 69482 71805 16475 54563 19069 15361 70699 72787 18226 218210 11370 55991 27207 67097 670832 633683 20044 27050 667279 14080 20085 668144 20084 67186 382492 20055 75617 27370 71978 65019 12306 629957 16410 20102 14083 20103 668668 667739 672214 66481 225058 71745 100038875 100038991 68028 100043000 67891 100043295 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 12317 432502 19087 19989 76808 19899 100043184 19921 19934 100043755 193740 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 18442 100037258 100043876 100043893 100043423 100042986 20115 67281 14583 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 18412 15481 72345 63873 20821 228998 100041766 66515 20111 50868 22346 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956522 OTC variants cause OTC deficiency 18416 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.3 Vif-mediated degradation of APOBEC3G 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70247 67923 21762 75717 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-6807062.4 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) 73166 15490 20787 13121 20788 74754 66234 18194 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression 15257 22601 18519 21388 18091 21679 14463 21676 21678 97064 230899 14219 15258 21677 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 96%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 52717 56436 99152 17463 668450 57296 20422 26445 26446 19172 19173 19175 19645 19177 26443 26444 19170 66413 56371 667035 27401 22190 59029 67089 70247 30939 20877 107995 21762 22123 20878 19179 19181 19182 217232 23996 56317 19184 59008 18817 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis 67054 231327 14450 237823 100042069 108147 23917 229363 11564 11565 11566 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 96%8851680 Butyrophilin (BTN) family interactions 19041 547431 238555 237754 195349 170786 12231 22436 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 96%5610787 Hedgehog 'off' state 12234 93687 56436 17463 57296 81896 20422 26445 26446 19172 19173 19175 21821 19177 19087 21402 56438 19084 26443 26444 19170 19206 66413 26965 667035 22190 59029 67089 70247 16568 18747 213081 237222 380718 16396 106633 22158 244585 319757 70300 271639 240888 14632 380614 110350 19088 104110 73668 245866 67661 56637 432530 210044 104111 224129 11512 21762 11513 22123 11514 14634 18222 11515 14633 19179 18749 19181 19182 23996 74682 19184 26440 19166 19167 24069 26441 73916 26442 69077 66997 23997 19085 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 96%168276 NS1 Mediated Effects on Host Pathways 18141 107939 74568 69482 71805 54563 16646 19069 100038882 70699 72787 18226 218210 69912 16211 103468 100039592 16648 19106 19386 234865 54196 59015 69736 54188 381686 110379 16649 170762 108989 231042 227699 223921 227720 445007 269113 66679 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 96%8942233 Intestinal infectious diseases 14917 170761 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.4 Truncations of AMER1 destabilize the destruction complex 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 12387 12562 19087 19084 11651 14697 54598 14710 63873 14699 66066 14700 14360 18747 14708 14706 14672 18442 14704 14695 14693 64337 14709 14682 78757 21894 14701 54409 18709 18706 22330 18607 74769 11535 18707 14702 18613 14696 18127 19088 56717 104110 109333 227743 432530 55991 210044 104111 14688 640703 224129 109270 11512 11513 11514 11515 12334 18749 12336 69543 17387 16542 14257 56716 19085 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport 19743 58176 56315 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression 232440 319149 667501 20019 15077 21340 21339 21341 64424 75316 81898 66420 70333 69833 11461 66136 245841 20017 110052 17749 100043714 93762 22385 15267 319168 319167 319186 328572 319178 319183 319182 319190 319955 18432 319176 21374 319181 56200 56637 20018 14534 20016 319169 18519 625328 78303 319188 15270 624153 382522 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI 13081 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells 16600 18514 383491 332221 620395 83557 20674 17126 17128 14173 53417 20848 26423 18999 99377 22773 100038891 13835 15221 13819 58198 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9818749 Regulation of NFE2L2 gene expression 12914 328572 17869 18033 18024 19697 18128 17135 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 18011 13388 16449 240055 225164 11487 54485 11491 16450 18128 667035 76580 22190 DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196854 Metabolism of vitamins and cofactors 11651 11816 665270 15519 15529 23888 20971 20969 77337 83702 21452 13361 71951 20970 14735 52466 14104 74450 68214 18127 73095 15530 71743 11806 75735 68087 211347 238055 67618 269614 106564 72621 66812 103978 73132 63857 18563 26464 55938 22361 18605 18606 11428 330064 209558 14733 19300 640703 79235 20525 170752 14734 68421 238505 210009 14873 18113 50500 78038 65107 72039 67861 17250 107476 22139 100705 239393 14276 22072 11603 110821 66904 17850 69060 109136 109791 19662 77697 109129 67096 19660 19659 100017 12182 108037 68453 67442 93835 59027 108156 17769 11433 16956 216225 65969 319945 71707 67375 17252 52710 246703 225994 105349 68591 107747 103711 69568 27973 20751 29807 71365 11807 17434 67426 11808 74080 99138 68646 320415 20527 110948 14528 78914 242642 66473 76889 69564 217707 268566 230027 105663 67914 11761 19286 230125 56075 102570 12850 223646 71883 16835 66454 227683 11813 54219 52064 11814 26363 100039707 192185 20509 69698 69372 69906 14725 214424 17768 15926 328417 54391 116914 16971 67287 80285 270685 52552 20425 109754 671535 67993 109672 547253 67795 54338 226518 20522 23959 216188 14603 19092 216134 67283 665563 12494 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9703009 tamatinib-resistant FLT3 mutants 14255 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function 79235 19659 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%71737 Pyrophosphate hydrolysis 67895 76429 74776 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 96%3296482 Defects in vitamin and cofactor metabolism 78038 93835 110821 66904 17850 72039 54219 109136 26363 68421 238505 65969 21452 77697 18563 210009 109129 67096 107476 14603 19300 110948 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria 15129 55932 109637 15122 640703 17075 667035 100041766 12363 22190 236573 14469 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5682910 LGI-ADAM interactions 11488 56839 243914 246316 54377 23792 13385 213469 11496 12300 56216 54376 81905 20907 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9715370 Miro GTPase Cycle 59040 67095 67414 70827 214952 229877 170731 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling 14082 22035 21933 12633 12370 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression 11998 21372 109151 59027 17977 20893 14068 66277 272322 18143 12457 79362 17978 59035 81004 66993 12753 18787 12914 20181 56406 19013 19014 229003 11865 CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 96%5690714 CD22 mediated BCR regulation 15170 12518 17096 15985 12483 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors 56484 100039786 54601 54401 56458 22628 22631 55948 23797 11651 11652 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 96%5578768 Physiological factors 104158 15257 18519 17380 21388 18091 18160 230103 53419 14463 18159 97064 230899 15258 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764302 Regulation of CDH19 Expression and Function 12385 20665 227485 12388 12387 230738 16480 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 96%75205 Dissolution of Fibrin Clot 94175 18788 12306 18815 18793 18816 20720 20194 20725 20719 18791 18792 18787 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948011 CASP5 inflammasome assembly STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 96%211736 Stimulation of the cell death response by PAK-2p34 12367 224105 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-HSA-1606322.3 ZBP1(DAI) mediated induction of type I IFNs 56532 56480 446099 69721 54131 207521 58203 19697 106759 71966 12675 16150 18034 16151 17874 18033 18035 13211 18036 142980 19766 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME DATABASE ID RELEASE 96%9636467 Blockage of phagosome acidification 108664 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 96%9007101 Rab regulation of trafficking 270160 93739 70785 22241 235633 54189 192232 227800 60409 211922 66687 225870 67443 207592 329260 19326 216131 69440 70296 67231 19328 106039 12663 217449 11651 11652 53869 77980 19339 216363 64930 19325 68328 22084 68365 226089 270192 19345 271457 19344 319642 22627 19346 242406 56382 74018 12662 11891 19349 71648 17274 80718 66691 67091 66226 19324 75964 11845 270096 217835 14569 66975 14567 72433 227801 102442 66682 76954 106572 19347 229541 68449 245828 72121 381605 67790 67046 72825 100855 320714 19341 216344 56486 59005 67844 108995 74760 77407 319934 78232 245886 19337 320560 269589 329727 74105 320435 224617 27096 226407 260302 105841 235442 19330 233204 76308 74030 56715 76510 329877 103724 23797 209773 19338 192236 209815 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 96%9845622 Defective VWF binding to collagen type I 22371 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding 12469 12461 14466 12464 30050 50762 14675 53857 24012 24128 19739 22327 22152 227613 50782 14697 22153 12447 50754 216853 50779 22142 12448 11461 14710 22146 14699 14976 66066 67199 14700 18637 108077 67466 67951 27055 14708 13001 71833 14706 13000 14672 100039026 14447 213980 14704 73710 14695 68628 14676 22145 22059 14693 12465 16553 64337 55946 14709 50789 545486 238463 30839 14682 67134 14701 109054 56612 20698 99371 14702 14696 15183 14688 20848 12466 22147 21454 12462 22151 106052 66887 242960 12467 30838 12468 22143 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME%R-HSA-5579027.5 Defective CYP27B1 causes VDDR1B 244209 BASIGIN INTERACTIONS%REACTOME%R-HSA-210991.3 Basigin interactions 11931 11932 11933 53896 30962 12389 50934 83995 16400 16403 20737 66053 20540 330836 17254 268373 16412 57274 80879 20501 20539 26570 12215 16728 17136 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 96%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 80838 66403 170644 19645 22059 15361 15364 15260 104248 16906 75560 56702 50709 14957 50708 14958 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654706 FRS-mediated FGFR3 signaling 327826 14172 80857 14180 64654 14175 18176 20662 14173 14164 15461 107971 80903 19247 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER 56438 667035 13871 16881 22190 66420 67439 69833 67710 245841 69920 20022 14885 66983 209357 71101 66467 71991 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 23894 14884 11834 27015 69745 59001 319955 22594 16882 19687 19718 69263 66979 56031 21399 18538 28000 68275 106344 72151 18971 68240 18972 252870 19891 18973 18974 67967 57905 99375 72584 13194 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases 245446 19280 18213 272381 75409 386750 233977 19024 67533 19268 60367 239250 68507 327814 76965 245450 331461 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 73804 19053 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 18817 110379 69928 13427 76499 13426 52504 13424 228421 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 96%426048 Arachidonate production from DAG 231871 269060 23945 76192 66082 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding 12469 12461 12464 53857 22327 22152 227613 22153 22142 11461 22146 14976 67199 18637 67951 73710 22145 12465 545486 238463 12466 22147 109054 21454 56612 12462 22151 12467 12468 22143 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670095.3 Inhibition of DNA recombination at telomere 319178 319183 319182 232440 319190 22589 57321 319176 319181 319152 21749 66420 13163 497652 69833 21750 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 319169 28113 625328 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression 319178 319183 319182 232440 319190 319149 319176 21374 319181 15077 21340 21339 21341 75316 101867 93759 319169 625328 15267 78303 319188 319168 15270 20937 319167 624153 319186 382522 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones 21990 13371 13370 70337 12389 213696 114479 107585 22094 214593 99439 13166 18948 66811 21823 106200 13195 12640 22018 11298 216343 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 17096 22612 18176 20846 20662 20851 20848 20850 15461 18710 16590 16818 18708 18709 16452 14360 18706 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%438066 Unblocking of NMDA receptors, glutamate binding and activation 53623 640703 14799 14811 13385 18039 14810 53310 11472 14802 13383 23859 14812 14814 14813 12322 12323 108058 12325 14800 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660514 Synthesis of PIPs at the Golgi membrane 234129 83493 225326 11842 67073 224020 107650 103199 18711 64436 320634 84095 18704 234729 75669 11840 18705 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema 58992 16621 14061 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) 242425 387513 54393 387353 387515 353148 353165 387348 14823 387356 108073 268934 108069 108068 210198 83771 574417 14816 387347 57253 12374 108071 57254 110326 387355 83770 387342 387349 387512 387616 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.4 Anti-inflammatory response favouring Leishmania parasite infection 13479 58861 246256 14131 11491 19087 19084 22612 217344 20620 14697 93671 16153 17886 26416 14710 14699 66066 14700 229709 14360 16438 16439 18747 14708 14706 14704 14695 16440 12502 14693 17096 64337 14709 14701 15162 14702 14696 19088 234779 19108 104110 20963 14678 18550 14677 14687 14679 432530 210044 104111 14688 16193 640703 70086 224129 11512 11513 11514 11515 14191 18749 14598 18803 319446 11541 23887 14129 242851 19085 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 96%164939 Nef mediated downregulation of CD28 cell surface expression 12487 11773 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling 14389 74769 18707 21682 16451 12402 22612 16453 20851 22324 20850 20963 107746 18710 12929 12928 17060 16186 19247 16331 14360 16332 16184 20416 16183 18747 15170 22631 17096 20662 16188 16185 12984 12982 16192 16191 15162 12981 18708 18709 16452 18706 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 96%8981373 Intestinal hexose absorption 20537 20526 56485 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 96%2871809 FCERI mediated Ca+2 mobilization 16428 21682 234779 22324 20963 12229 229709 16438 16439 22165 22325 640703 19055 19056 16440 18018 18019 57257 19058 17096 18021 20662 17444 18803 16822 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 96%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) 74338 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-HSA-8850843.6 Phosphate bond hydrolysis by NTPDase proteins 72090 67464 12495 93685 12499 12496 12497 215446 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping 19353 13543 71893 22418 16476 241275 13542 13057 26419 14369 237038 13544 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 96%8939256 RUNX1 regulates transcription of genes involved in WNT signaling 12400 13982 12005 72780 20371 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation 17248 328572 50883 241764 17246 110147 22059 57748 11920 67956 77683 27374 667035 226830 22190 219022 BINDING AND ENTRY OF HIV VIRION%REACTOME%R-HSA-173107.5 Binding and entry of HIV virion 268373 12767 12774 12504 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO 68525 93687 16568 319757 59056 16147 74239 104346 230500 14451 57810 110355 117606 20423 19206 109689 216869 13363 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins 11832 64008 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 96%9660821 ADORA2B mediated anti-inflammatory cytokines production 14702 14696 19088 19108 19087 19084 104110 14697 14678 14677 14687 14679 14710 432530 14699 210044 66066 104111 14700 14688 16193 18747 14708 14706 14704 14695 224129 11512 14693 11513 11514 64337 11515 14709 18749 14701 11541 242851 19085 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 13388 16449 11487 54485 11491 16450 18128 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020558 Interleukin-2 signaling 20850 16185 20963 16451 16818 16186 19229 16184 16453 20851 20416 16183 MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis 56532 74568 12370 19766 RAC2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013404 RAC2 GTPase cycle 26934 110279 330177 18806 75409 105855 242687 216963 17969 20947 13511 70497 12389 11308 22324 22319 277360 192662 13058 18710 13057 19349 26431 17970 70584 101314 17972 66898 70361 71302 233103 22325 71544 229658 16412 13726 23943 75739 57257 29875 71782 94176 330662 94190 71703 52331 218581 84004 21917 56699 56491 109904 224105 238130 18708 18709 20430 18479 56419 70804 380664 18706 104445 13836 59079 223666 69922 223435 98386 330914 232906 71435 228359 23853 19354 66508 17827 68653 21844 208869 195727 210293 50884 71709 22042 329165 109934 WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL 13543 13001 13000 100039026 18719 13542 27373 13544 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 96%211163 AKT-mediated inactivation of FOXO1A 56458 23797 11651 11652 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions 56208 69940 12387 319149 107338 15077 15381 18005 78757 19298 22352 70233 218978 19655 73075 15516 70616 269061 68598 67959 17087 17395 100040603 232989 107701 11806 67480 72047 68092 74326 67500 433702 75956 56031 80744 21898 66270 70225 68879 320632 67418 212880 66585 74351 83486 74370 71586 66877 23983 18521 228607 83701 217069 57905 68479 16834 15569 209416 20222 66899 60321 17713 66070 23845 66810 319322 19205 27967 76936 71702 68981 20639 229279 101943 81898 67439 94315 20646 192159 11993 53317 15382 53379 56258 59013 98758 11991 11834 15388 15387 18571 66055 68816 19766 54633 67465 69192 67285 236732 67958 68183 76479 20624 66642 20847 75062 77134 21349 27366 13205 28000 13204 76938 13207 233908 66125 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 74320 68188 54188 19899 12322 12323 108058 12325 13163 192292 15519 15529 216965 23888 20971 20969 54196 71951 20970 14735 14104 15530 14061 103978 14733 64340 622469 76246 225027 15481 67996 214498 22608 51796 66317 71713 233073 235497 14734 22083 20382 110809 20383 54624 21681 18035 108014 18036 192170 69207 19826 75669 100040029 225326 107686 384091 666609 21872 68705 20641 98053 20638 66420 69833 67710 245841 69920 67332 20022 20020 11603 231329 20021 69241 625018 17749 100043714 69116 22196 621893 15568 319162 15267 319173 319163 319168 22370 319167 319186 317677 319178 12759 319183 319182 17195 319190 12259 56489 56717 319176 319181 72512 13211 214763 227743 51810 319169 109270 78303 319188 319189 56716 382522 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) 11416 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription 21679 21676 97064 21678 22601 12399 14219 21677 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 20201 20202 11909 26419 12675 16476 18033 18035 18036 24088 11820 21897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 21899 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 22030 12475 67245 18034 12229 434174 66513 93765 66589 22034 66724 68652 20111 12703 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling 19353 73178 330662 231148 226251 17973 223435 13176 20779 18208 14083 319713 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) 12870 53945 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%391903 Eicosanoid ligand-binding receptors 574402 58861 16995 70086 19214 19222 14764 19217 19216 19220 19218 19219 57260 21390 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME%R-HSA-9664424.3 Cell recruitment (pro-inflammatory response) 15368 16173 66824 216799 19697 69146 12495 12499 18034 12267 16175 19200 54483 12266 18438 16176 12362 18033 18439 22166 67955 56338 13035 23959 15516 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction 22004 11472 13405 22138 59069 11474 21925 21393 50876 21957 233199 21954 50875 17868 50874 13346 17883 21956 17888 109272 17885 17996 21924 22352 21916 21953 21952 21955 17901 17906 17897 17896 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-HSA-73933.4 Resolution of Abasic Sites (AP sites) 18970 14156 59001 11792 22594 16882 19687 19718 69263 59047 66979 17193 71726 11545 382913 18294 72774 16881 18207 18538 11546 68275 106344 72151 18971 68240 18972 19891 18973 18974 268395 67967 69745 26430 100206 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4615885 SUMOylation of DNA replication proteins 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 21973 21974 21969 18538 69912 103468 19386 234865 11799 59004 52276 20610 20878 59015 22196 69736 100043429 16319 110379 229615 20877 170762 108989 231042 227699 223921 227720 445007 269113 66679 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 96%437239 Recycling pathway of L1 56613 74947 73086 20404 11771 11772 103967 71770 22350 26413 71653 20111 232910 11773 13430 18222 110651 16571 20112 16728 67300 13429 12757 19684 12934 17698 67071 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 20924 23894 14884 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 76246 21343 209361 214498 226182 12454 229906 66317 235459 24074 83602 58202 68153 235497 74197 67923 22083 27224 27632 24116 12455 72949 54624 13716 63856 64144 20926 93736 70122 74427 73473 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora 13853 105193 667035 22190 14936 27357 53412 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.5 NEP NS2 Interacts with the Cellular Export Machinery 18141 107939 69482 71805 54563 19069 70699 72787 103573 18226 218210 69912 103468 19386 234865 59015 69736 110379 19384 170762 108989 231042 227699 223921 227720 445007 269113 66679 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription 328572 12914 15213 14534 15214 18129 18519 18128 333639 18132 17127 15205 270118 15208 19664 14257 103806 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 96%8849474 PTK6 Activates STAT3 20848 20459 12702 106766 SIGNALING BY RNF43 MUTANTS%REACTOME%R-HSA-5340588.4 Signaling by RNF43 mutants 14370 14367 14368 16974 207742 16973 14366 22416 INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME DATABASE ID RELEASE 96%5659898 Intestinal saccharidase deficiencies 226413 69983 CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 96%110331 Cleavage of the damaged purine 319178 319183 319182 232440 319190 57321 319176 319181 234258 319152 18294 21749 497652 21750 319169 268395 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 96%2243919 Crosslinking of collagen fibrils 16949 94352 16950 69675 67573 18542 24087 21892 12153 16948 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 96%9918432 Maturation of DENV proteins 66357 68563 66624 12282 13200 233726 11806 16646 12317 66286 14827 18453 103573 18452 20014 66861 235623 103963 667035 12330 22190 69038 13135 76687 69019 18451 16211 100039592 16648 100037258 56529 67075 171210 13480 22196 13481 381686 16649 14828 320452 67838 80286 18107 68292 19092 16430 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling 12234 77647 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 192656 12042 66413 26965 667035 19211 22190 240354 59029 26409 16331 67089 103583 70247 12500 12501 12502 12504 18708 18709 18706 18607 74769 100041766 216150 93765 66589 18761 22034 14969 14968 68652 21762 22123 12675 108723 19179 19181 19182 23996 19184 18033 26440 19166 216080 18035 16818 19167 26441 26442 69077 66997 23997 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME DATABASE ID RELEASE 96%164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 252903 12487 232910 11773 12504 11771 11772 71770 15007 16818 12526 12010 11768 11769 108012 11764 11840 107975 11765 108664 11767 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription 216848 13626 107932 52615 19646 234366 26413 26417 21907 56233 19712 245688 22059 19016 12418 23942 17192 13498 14013 68877 229542 12151 19763 20613 54383 13619 56717 13653 241915 12416 19821 15184 99982 217864 15183 66508 116871 545987 116870 54170 20583 14056 11909 52187 494448 68576 66096 83409 74370 68441 30951 268706 245670 16476 99377 433759 56716 15182 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 270160 28169 54160 74947 108148 56494 16570 107338 66111 54399 53357 109181 73470 16563 16568 234663 213827 11844 53334 68097 73804 67511 53598 56358 56444 67665 22428 56455 13191 12121 76895 12344 26951 18476 59288 16594 18475 229841 668303 16579 232943 75985 19348 71819 16593 105785 16551 22365 110033 17113 13047 209737 11840 74764 18472 235661 18195 76932 73296 108123 108124 16004 74375 76332 16834 226089 76688 270192 53611 56367 13427 319642 102339 19157 19346 13426 67474 98910 19159 58244 13424 19158 70646 228421 72318 78304 27277 338337 73124 104303 17957 67542 26934 78689 242406 56382 53330 228960 69834 224705 76899 245944 97484 68505 233824 54214 232286 240641 68299 22319 269152 227746 16565 70297 16564 16552 16580 16581 67023 16561 16562 72772 16558 70218 56418 20932 75050 16554 286942 71116 16578 319991 16572 66251 224630 16573 16560 56447 54161 18783 77038 56389 59042 76877 69654 11650 228998 68137 66905 17155 17156 230815 11843 19324 66913 12343 12345 100042773 20333 11842 16569 12340 50797 70349 16571 12847 54130 14423 226407 19330 17158 76308 100042343 19338 ASPIRIN ADME%REACTOME%R-HSA-9749641.4 Aspirin ADME 76408 394433 71773 100727 100559 436059 231396 13106 394434 94284 552899 223337 72303 107141 56448 13114 12780 11657 104158 20501 12215 107146 233799 12038 233801 272428 435528 22236 94215 72094 394436 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%156711 Polo-like kinase mediated events 328572 12532 75660 268930 12442 108000 18817 14235 19646 22390 17865 72568 12530 231506 629959 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE 74182 232889 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702636.2 tandutinib-resistant FLT3 mutants 14255 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-HSA-3134975.4 Regulation of innate immune responses to cytosolic DNA 56480 446099 54131 207521 58203 20821 384309 22040 72935 72512 69807 667035 22190 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 96%5578996 Defective CYP27A1 causes CTX 104086 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function 77974 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159227 Transport of the SLBP independent Mature mRNA 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 69912 13684 103468 19386 234865 59015 69736 21681 110379 170762 108989 53319 231042 227699 223921 227720 445007 269113 66679 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis 19139 110639 75456 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-HSA-210745.3 Regulation of gene expression in beta cells 103988 18508 16334 21405 18088 18096 56458 15376 18012 18609 20526 378435 15377 11651 320995 15874 11652 30942 23797 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 13138 68273 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 18747 18639 18640 19052 170768 21770 19053 51792 270198 73699 18749 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 96%1474244 Extracellular matrix organization 13406 60409 12550 244431 13405 69675 20650 13528 13527 20649 17182 24051 20648 20391 24053 24052 18787 16651 268534 20392 16416 14161 18810 21825 110135 99571 16948 16949 94352 13038 16950 109711 67573 17395 268958 13039 12339 23830 17394 17384 56213 17388 23948 58223 17229 72947 50817 18452 269120 72902 12305 18550 17150 216760 76293 14115 14114 170725 18214 19035 64706 11502 50530 240047 18451 11501 17391 381122 23876 216616 14119 58859 22288 73647 14563 268935 12335 12338 12215 30800 12337 13717 12476 23993 12334 17385 12336 17381 71753 57764 69543 13497 16542 320452 16456 12380 12333 17228 15896 12817 12816 22139 12815 12814 12831 12813 94216 22072 12830 373864 12821 107581 77018 12819 53867 16412 12829 12828 12827 12826 12825 69700 12824 12822 19164 71355 12841 12823 73368 12840 59287 213945 12818 245026 140709 237759 12839 329941 12837 12836 12835 12834 11492 12833 12832 18453 50701 16419 232345 23794 13033 30806 271127 208936 21858 21857 11504 16410 21803 21808 13003 17387 17389 17393 13035 240913 56693 269132 237360 12032 14789 104099 330119 13179 21809 12406 216725 268977 18822 16997 26432 13138 16998 26433 20750 210530 12111 56401 320910 76477 13004 18542 234407 108075 16420 241226 17022 12154 14264 24087 17967 21892 12153 15529 213119 20971 20969 20970 16621 18189 12505 19280 12159 17392 15530 83995 12361 18590 11487 11491 14173 12367 192897 109700 16398 18074 16400 16403 18073 16404 11603 16408 66695 15898 17183 381924 17180 16407 21960 16409 18198 22329 16775 319480 81877 16776 16421 329278 16777 21923 14218 666279 16779 83964 12950 16780 16423 228357 226519 16411 16399 14268 16414 16782 78369 16401 16772 67374 16402 11490 23928 15891 11489 16773 12845 16774 14118 22370 13040 13030 18591 12843 12842 18613 17386 15894 12162 66473 12156 17390 18815 20692 18750 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%109703 PKB-mediated events 18576 11652 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) 63993 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis 13853 667035 105193 22190 232493 14936 74185 27357 216558 53412 72157 SENSORY PERCEPTION OF SALTY TASTE%REACTOME DATABASE ID RELEASE 96%9730628 Sensory perception of salty taste 20278 546729 20276 20277 240669 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions 12291 239556 14573 13004 20452 12295 12296 12297 12298 14586 19122 14585 19197 14588 17967 12830 11603 12292 12289 12829 12828 12827 12826 21367 12841 12840 245026 12839 18188 12835 20450 12834 58226 11876 12288 12833 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall 11931 11932 11933 22612 12389 14786 20737 66053 16331 14360 20416 15529 20971 20969 17096 18176 20662 16416 15461 20970 12505 18708 18709 56744 18706 74769 238055 18693 14061 83995 14733 16149 268373 57274 21912 80879 20501 19123 12215 22363 12481 18803 20339 17289 69524 19261 19128 108078 12523 22364 20343 14456 20345 13052 20340 64435 270152 13449 71683 16456 12506 58217 171486 18106 16069 16400 16403 16408 16412 14127 243816 16409 83964 16423 16411 14268 16414 16401 16402 67374 21687 11600 17075 18613 21933 53896 21824 30962 50934 19124 68891 19247 20540 11601 330836 50915 11602 15170 17254 20344 20539 26570 17319 16410 21803 16728 16818 17136 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-HSA-174430.6 Telomere C-strand synthesis initiation 18969 18968 19075 19076 68964 108689 57321 69535 28113 101185 21749 497652 21750 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702590 gilteritinib-resistant FLT3 mutants 14255 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 96%1483213 Synthesis of PE 14245 71760 99712 75320 64898 68671 12651 237928 320951 28042 12660 64899 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%416993 Trafficking of GluR2-containing AMPA receptors 53623 14799 21912 243547 74053 14802 18195 18693 11771 18752 18751 18750 14800 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-HSA-174437.5 Removal of the Flap Intermediate from the C-strand 68275 18971 327762 68240 18972 14156 19891 22427 57321 67967 28113 101185 21749 497652 21750 69745 18538 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins 18141 107939 69482 71805 17246 18854 54563 19069 70699 72787 19720 18226 218210 69912 103468 56469 19386 234865 59004 59015 22196 69736 110379 170762 22346 108989 231042 227699 223921 227720 445007 269113 66679 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654720 PI-3K cascade:FGFR4 327826 14172 80857 14170 14180 14177 64654 14175 14388 14173 14164 83379 80903 18708 19247 14186 18706 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8853383 Lysosomal oligosaccharide catabolism 110173 73744 17159 17160 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport 20518 20517 30805 20519 18400 108052 27411 20520 67473 67582 70840 242126 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1793185 Chondroitin sulfate dermatan sulfate metabolism 11881 15931 12111 121021 212898 13004 244757 78752 72136 60322 269941 58250 74241 53374 77590 319901 59031 29873 338362 13003 110006 77042 71797 15586 109685 70893 234356 15212 78923 15211 12032 13179 15932 12091 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 96%167826 The fatty acid cycling model 22229 22228 20523 74011 22227 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation 13813 20613 20997 14182 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 96%209563 Axonal growth stimulation 18053 11848 192662 18049 CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.10 Cell-Cell communication 233833 16451 20665 12388 232440 19089 12387 13200 13626 12550 319149 20586 11472 20779 13858 15077 104836 13345 19303 12558 21417 52615 19646 26413 26417 14360 21418 22325 13001 13000 100039026 17869 245688 11474 29875 18109 209462 18810 22160 16480 18708 18709 16452 18706 22330 74769 66357 109711 224619 66286 228839 18550 18553 69019 93759 226970 73341 56529 12476 12695 22177 224912 56217 13017 13016 19261 16456 20683 93742 56513 12488 50791 68794 20163 54631 170643 21754 170736 74202 54353 57342 67703 218952 243911 16202 668101 225341 12821 16412 330662 56198 140580 192176 77630 11492 239096 11797 12385 59058 110751 12564 15426 66624 16201 330914 20613 12552 57875 15227 11798 73178 54721 99982 76687 228913 11727 14083 17974 217734 99011 20740 17973 11735 20742 19645 22323 12330 20901 60611 16601 114142 12741 16600 53325 17246 19229 16193 12555 93760 13430 12561 21762 22123 19179 21844 19181 19182 64945 67956 23996 71740 19184 105837 18033 58235 26440 19294 12361 19166 94332 71908 19167 15220 60363 26441 54420 58187 26442 54419 69077 12738 66997 93737 23880 23997 54725 56863 12737 56436 75677 17463 215654 57296 320873 20422 12565 24136 26445 241201 26446 12563 19172 53624 19173 12562 19175 12739 15376 19697 12740 19177 12560 12557 12554 26443 56492 26444 16195 22431 19170 621628 21423 18759 14694 192897 75339 66413 330222 192173 667035 56173 22190 239857 16403 242653 239931 59029 230738 18746 16194 67089 76007 56805 70247 58220 21406 237979 21885 58998 18554 227485 18417 227377 114141 16780 16423 75234 16782 15267 319168 16774 319167 13040 13030 76850 239528 319186 319178 319183 319182 236511 319190 319176 319181 19353 20014 213988 103963 217351 60595 214150 69038 13135 19247 20583 14056 18717 15170 17454 319169 57377 20848 625328 78303 319188 15270 433759 624153 15182 16430 14376 382522 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 96%180786 Extension of Telomeres 208084 14156 72171 245474 214987 214901 20174 68964 72107 108689 69535 66181 12566 216853 68147 16881 52530 21752 18969 18968 19075 19076 28113 101185 69745 327762 12428 269400 22427 57321 19687 19718 69263 56505 21749 497652 21750 18538 105522 12144 68275 106344 72151 18971 67857 68240 18972 19891 12427 52036 67967 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 96%948021 Transport to the Golgi and subsequent modification 193813 12068 53618 54160 317717 56494 60409 89867 11733 235416 11735 216131 107338 67231 14595 66111 640524 66890 20742 20741 54399 20743 217615 338366 12640 68947 80297 20451 234663 224139 21802 213827 11844 53334 68097 241230 67511 53598 56358 20450 14799 56444 67665 104318 22428 56455 13191 71665 12344 59288 56336 56386 242362 105785 11840 64138 235661 18195 108123 108124 57370 76332 53418 16834 56375 110379 11839 13427 102339 13426 13424 99412 338337 17957 67542 16334 66397 97484 17309 69608 233824 218811 99683 56418 70361 77371 20334 66251 56447 54161 77038 12836 56389 59042 56395 69654 16866 228998 68137 17155 67091 17156 20703 230815 11843 66226 19324 66913 105522 243819 14067 69162 14275 12793 12343 67857 12345 100042773 98388 20333 11842 215474 207352 74498 66682 12340 103534 50797 52036 76983 13032 70349 245828 12847 12794 54130 240667 67727 269181 214895 59005 217664 14069 78232 107895 56041 333883 21787 27096 20443 72978 17308 227648 17158 76308 20440 76510 67569 20739 100042343 20740 50907 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME%R-HSA-9825892.3 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 21415 12387 12575 21414 21416 16842 15254 17295 12443 12566 20466 21385 18817 433759 12578 12531 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-HSA-198933.9 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 270152 58217 246256 12550 15896 15006 12483 240095 667803 232801 14991 30925 217304 26904 14130 217306 100043861 12266 16641 16408 16643 232790 16412 15898 71326 140792 12500 50928 52685 12501 75345 22329 12502 21947 16421 57781 17086 231805 170741 84544 16414 243958 16401 78369 243864 54215 75863 629970 100038830 52855 15007 328833 12010 12526 83382 246746 12478 20612 12520 319352 27007 54698 18146 12480 20400 12525 225825 224840 17470 140497 23900 15894 83433 22177 19294 217303 20343 13052 14129 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling 54170 208643 52187 68576 66096 83409 74370 68441 56717 268706 14225 67605 245670 667739 13631 56716 75705 66508 545987 13685 13684 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.3 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 232440 20602 319149 23989 19645 66853 59024 11450 14732 18631 327987 15077 57435 20249 68801 66310 21835 140858 14311 68975 14081 234959 213464 12606 20181 11350 28077 70208 12491 21664 55982 171285 23808 11520 56771 15267 319168 319167 19014 264064 319186 319178 328572 319183 319182 67279 319190 21372 16475 231051 57875 17977 67278 23945 319176 19017 16890 16956 319181 17978 81004 14245 69790 56310 103968 26896 15183 20185 93759 17979 216154 67800 12914 56406 51813 11770 26424 319169 22289 27273 69792 67512 625328 67381 78303 319188 15270 170826 12568 624153 381022 382522 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling 233833 56436 17463 57296 12534 20422 26445 26446 19172 19173 56458 19175 19177 26443 26444 19170 12445 260409 66413 667035 22190 59029 67089 70247 18747 81489 17869 15507 545156 104252 58804 19373 224105 19374 218294 76850 18479 140486 239528 18612 17165 235072 236511 18481 225724 50772 229776 103573 19353 213988 217351 214150 17979 17454 21762 22123 19179 18749 19181 19182 23996 56484 19184 16476 26440 19166 19167 26441 26442 69077 66997 23997 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME%R-HSA-5619052.4 Defective SLC9A9 causes autism 16 (AUTS16) 331004 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 96%5358346 Hedgehog ligand biogenesis 56436 17463 57296 20422 26445 26446 19172 11491 19173 77583 19175 19177 26443 26444 19170 269523 66413 667035 22190 59029 67089 70247 74126 20423 13363 214240 226861 18453 216440 103978 66753 16147 116891 20338 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 96%5625970 RHO GTPases activate KTN1 19353 16709 16572 11848 16573 16593 56212 74764 16594 232943 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 96%5637810 Constitutive Signaling by EGFRvIII 12539 13649 12402 18176 14388 20662 15461 18803 13645 18708 18706 20416 15519 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias 13521 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) 30962 20532 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 96%2980766 Nuclear Envelope Breakdown 18141 23825 107939 69482 12534 71805 54563 19069 70699 72787 64899 18226 218210 14245 18751 64898 69912 103468 382030 22367 19386 224640 13726 234865 12442 59125 67181 59126 217718 59015 69736 18817 110379 16906 170762 108989 231042 18750 227699 223921 227720 445007 269113 380664 66679 DEFECTIVE LFNG CAUSES SCDO3%REACTOME%R-HSA-5083630.4 Defective LFNG causes SCDO3 18129 18131 18128 18132 16848 GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones 16326 22094 16325 12640 16324 16323 16866 16322 14308 PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer 12575 268980 18183 83961 320207 100042150 20779 17295 11651 11652 22324 18710 12576 14255 14360 327826 13649 21802 12015 12371 78757 30955 18708 18709 18706 18607 74769 18707 12487 12519 12524 17246 12223 71920 13874 15200 211323 19354 22084 12064 12675 67605 14388 15234 18212 56484 18205 78405 11839 13645 80903 384783 14186 14165 83490 18596 14389 77647 16367 18213 14172 80857 14170 14180 14178 56458 14177 67112 64654 14175 14174 14173 14164 83379 19211 13983 13982 18595 58988 12478 18591 54601 56212 56717 19353 56637 14256 227743 19247 104709 13866 109270 15370 606496 16818 16590 56716 23797 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 96%1442490 Collagen degradation 13038 17395 11487 17392 17386 11491 17394 17384 17388 58223 50701 72947 83995 18550 12817 12816 13033 11502 12821 107581 77018 12819 17390 30800 12822 12841 17385 12823 17381 71753 12840 17387 12818 140709 17393 237759 12839 13030 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%R-HSA-201722.7 Formation of the beta-catenin:TCF transactivating complex 21415 232440 12387 319149 20586 16842 15077 66310 140858 21752 213464 21885 17869 75410 21886 21888 23808 100683 15267 319168 77578 68911 12006 319167 80288 319186 72135 328572 319178 319183 319182 81601 21414 319190 21416 17283 12399 319176 319181 319152 56505 214498 12914 21887 235497 319169 625328 78303 319188 15270 433759 624153 382522 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-HSA-9006936.9 Signaling by TGFB family members 233833 16998 68010 17872 320910 65112 20602 14479 108075 16420 211586 170749 12402 56207 241226 23893 21781 12165 11705 110542 218441 12154 17129 18121 55994 83554 12166 66105 11545 12167 12168 97064 11482 14314 20901 26413 18787 26417 20482 19047 20481 17869 94093 17125 17126 17127 17128 18109 16416 66313 17130 109689 17131 216869 21815 328572 22284 103573 228839 18550 16477 21812 21813 107951 20185 12579 22608 12454 18002 13559 104394 21413 17877 17878 17927 19042 11481 17928 14225 12455 12622 72949 269275 11479 75788 19650 16456 18762 11848 102098 20683 70737 93742 56513 14173 21423 667035 22190 21406 20181 14106 14313 66556 16412 19164 19165 100042305 208117 19401 59287 100039623 16324 264064 76850 239528 12843 236511 56424 17283 19045 16419 83814 213988 217351 19046 214150 93836 67821 51813 12156 17454 21858 21857 15201 16323 16410 22192 16322 21803 21814 21808 118445 67903 17387 11480 433759 216080 17389 21809 268977 16997 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR 11487 58194 11491 20408 12402 56324 24063 20779 19272 24064 15239 16206 12223 20404 239463 94212 71920 20844 13874 20405 13858 15200 19303 208994 667035 19248 22190 13854 19247 12988 20416 54126 13649 21802 13859 18176 20662 14388 15461 11489 18803 11839 13645 18708 227290 18706 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 96%1295596 Spry regulation of FGF signaling 19052 109880 19053 51792 667035 22190 12402 24064 19247 17346 26413 26417 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication 18969 18968 12534 19075 19076 211586 13555 73699 19645 21781 50793 19052 18392 18393 19053 66634 51792 26428 26429 56452 RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME 71279 18950 269346 63959 11534 18102 11486 76952 18103 114304 16434 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs 13106 72303 13077 56448 13114 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME%R-HSA-9958825.1 Activation of STAT3 by cadherin engagement 56436 17463 16451 57296 20422 12388 26445 12387 26446 19172 12550 19173 19175 19697 19177 20779 26443 26444 16195 19170 104836 66413 667035 22190 59029 16194 67089 70247 22325 227377 75234 209462 330662 13040 140580 16480 13030 16452 22330 11797 12385 12552 224619 11798 19353 54721 226970 16193 21762 22123 19179 21844 19181 20848 19182 23996 19184 18033 26440 19166 19167 26441 26442 69077 66997 23997 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 96%5663213 RHO GTPases Activate WASPs and WAVEs 17973 105855 242687 330319 76884 76709 19353 73178 11308 12229 56443 108100 11461 26413 101314 26417 80987 68089 67771 11867 11350 56378 66713 74117 245880 14083 22376 215280 11465 68524 50884 83767 20430 329165 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine 435528 107146 233799 233801 272428 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943962 CHD6, CHD7, CHD8, CHD9 subfamily 328572 319178 319183 319182 232440 12387 319190 319149 109151 13018 319176 17135 319181 72293 241128 15077 320790 140858 18104 18024 71389 12914 16002 56811 319169 625328 15267 78303 319188 319168 15270 12006 319167 67772 624153 319186 382522 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 12021 81601 327762 20422 233826 19361 114714 22427 19362 11920 12189 12190 237911 57434 19360 225182 26909 17535 21975 19363 19364 12144 27354 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion 18796 18797 14672 14682 74205 18795 12491 14676 233081 14675 50790 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 96%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 17874 54123 16179 170743 93765 66589 22034 81897 266632 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) 20682 217031 226976 12389 208146 66853 18631 76719 57435 68801 75812 21835 14311 12640 69556 69612 101206 14081 13486 217588 54194 108946 67933 665775 75565 228714 67773 239510 21664 77305 269061 18550 20869 64930 66508 545987 54170 22084 52187 68576 66096 83409 74370 68441 19042 268706 83701 245670 20683 18044 18045 18046 14732 20249 81898 13436 13435 13433 14102 12362 16396 670717 108155 56424 21933 22061 12028 11727 68626 64144 20926 93736 70122 74427 73473 12322 12323 108058 12325 18747 12491 12418 54343 11569 77683 22166 20937 84505 12151 17248 17165 19763 12428 17246 54383 13619 110147 26399 241915 12416 19821 12579 12578 16193 494448 12427 12608 30951 12064 14812 13388 16449 384091 666609 75339 27374 20638 56698 67332 29813 59092 50883 228829 74522 12326 14811 20620 70625 68975 227644 13865 66653 243963 77634 234959 20841 12419 102209 21418 330959 76184 75627 94112 15213 67268 70208 17988 21849 69020 13649 21802 14723 55948 94093 228876 15111 67731 268417 14751 23942 209225 56771 50493 21825 80509 104625 22160 21815 67911 214669 226896 240068 13395 108083 21833 15257 13038 77827 18983 98386 13039 210104 384763 239985 72611 269704 12702 14462 16854 14461 228839 14460 71361 14463 16477 67065 233107 71752 14776 74414 56310 233863 72780 72308 237775 66596 208043 78929 26896 544971 14800 70239 15258 269252 218772 26939 19411 67486 103988 70408 52897 20018 75747 69870 80707 70428 54526 67371 16880 218832 14534 67005 17700 20016 244556 98488 12857 12909 110109 619310 12450 12452 69131 30944 237758 53621 75284 110323 72322 19664 14000 72068 229543 14579 70422 12861 109077 232791 68510 19650 71177 17863 18987 19651 210925 12862 109019 17865 18130 12868 75137 68943 77065 66142 269344 216848 69917 232232 93697 12866 68991 12865 192657 233056 69882 100041785 72656 208836 231571 77519 218333 109648 71957 18129 101861 18131 70885 170936 71793 18132 225283 107932 57432 666581 70470 12662 675812 72119 243834 170787 18148 53376 19211 333182 22775 239546 230899 75605 68428 16184 216456 16183 434377 66494 110052 100039786 19712 19713 71131 619331 26992 243906 15510 22648 381549 71063 319974 68742 235682 68094 83796 83797 57376 72720 19246 243743 244713 544922 380975 72306 268936 229542 434178 22658 12705 22750 17684 23988 67279 19258 72154 59027 67057 225872 17283 17992 69076 18718 18741 74400 15228 56353 230162 72723 22704 14229 22757 226830 70315 21349 210135 93836 193452 18986 11864 17979 67821 244349 80902 13866 13864 74747 210503 93681 57264 26424 232784 330301 74120 18519 449521 245368 15370 109594 17702 22654 16909 11783 56707 16825 57745 69562 242109 64384 22761 30942 15378 195522 77044 18534 103836 22632 20750 269870 12020 20393 20375 22696 18854 245595 56314 353187 70227 79221 667501 110616 57230 11816 21429 59024 20019 327987 269003 72180 21340 236193 21339 432769 21341 66105 64424 67296 22130 52712 75316 231866 70333 233904 116848 22294 66136 20135 20017 234725 192292 83766 80751 23957 21907 11350 20482 20492 74570 72290 20481 116748 20183 20182 71041 75410 101095 238690 17125 17126 17127 17128 69181 75692 76073 17192 12741 66313 17130 21981 17131 17132 228140 67235 268859 56744 103806 56525 14312 16600 70088 13496 53325 69125 22640 209456 11604 319955 219024 106298 228491 219103 333639 22284 56456 18124 66813 53892 22062 56200 319801 213011 223272 99890 69790 22678 68527 58184 19885 243372 22026 225998 52679 50496 22608 13559 104394 241764 12858 93760 233893 66923 107986 353310 76390 21762 13198 22123 14634 13197 14633 19179 57748 19181 14660 19182 67956 23996 268973 19184 75788 18033 230784 26440 16653 19166 170826 20463 19167 170574 12981 26441 12978 74352 26442 64050 69077 76367 66997 381022 23997 69260 216151 14381 56436 14377 17463 78893 57296 19293 20422 70472 26445 16334 26446 327963 19172 69228 19173 225655 19175 56458 19697 239652 19177 52846 21402 94223 78251 26443 21388 26444 18091 332937 19170 21423 231464 67010 232854 66413 22709 26965 70650 16179 667035 18387 22190 18390 18751 64058 240064 59029 223828 21408 13983 67089 75613 14219 70247 21406 68744 22260 17708 20181 17709 22337 72198 17710 19013 22693 16408 13982 12795 22025 14431 19883 26913 11835 72739 18227 72556 14815 26381 272347 26380 208727 26379 19016 57913 22196 16399 100043429 12366 16401 26423 16402 19401 106931 12368 21834 20787 18667 233060 69234 19360 56338 13831 264064 17535 12053 21975 12359 18022 19364 84682 27354 15978 12021 12843 12842 20807 81601 56187 327762 54601 19352 17386 19361 330463 170740 243621 22427 333654 12399 19718 192651 69263 20371 15574 20604 11920 16009 16006 12189 83814 22689 235610 68036 231724 12227 237911 15185 19355 12122 66262 225182 12142 15184 26909 22751 18538 27274 235559 11863 17433 12144 20527 216154 68275 20467 106344 78783 72151 211651 14088 68240 51813 12156 252870 19891 72230 15469 212712 12177 19367 69792 19356 12417 15205 20878 20466 12649 108961 217232 18996 56317 18997 59008 67381 19015 66156 72805 216080 12905 69957 219022 17222 22339 75430 56222 68612 666311 52563 15182 22194 71393 68999 15194 52206 12226 100039535 319530 52717 15161 244219 99152 22690 668450 17187 12534 100041581 56275 12387 20602 11906 23989 67155 20586 170753 20779 20588 20587 56461 17295 60599 67338 270118 235956 17191 13345 21936 241196 235028 26416 433766 66214 12005 29808 16656 234366 26413 18787 26417 240087 77976 12545 107568 67370 28077 56233 19094 234594 382985 15214 244216 54401 171285 21420 21419 19014 11865 328572 19285 21372 17977 74322 19017 103573 17978 59035 81004 66993 17260 15183 20185 93759 217166 12914 56406 11909 640703 18019 20656 56484 16476 18477 21672 66899 22627 12569 12568 12125 14103 12532 18128 56438 55982 93762 22385 12918 57875 16956 50724 60406 94246 100041953 16147 71954 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 14415 74320 14417 68188 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 12447 56371 27401 13163 12448 12576 73699 11799 19052 19053 51792 20877 431706 26931 76246 214498 66317 235497 22083 54624 18861 17685 17350 70127 21872 29861 269397 19708 268996 68705 98053 13871 12055 66420 12054 69833 67710 77045 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 21679 15267 21676 319168 21678 319167 14281 76850 239528 319186 21677 319178 319183 319182 236511 319190 18432 241113 56717 319176 319181 213988 217351 56637 214150 227743 19247 116871 116870 14056 17454 319169 109270 105787 67512 108079 20846 19079 108097 625328 78303 54427 319188 100039610 15270 622480 19082 56716 624153 23797 382522 233833 21415 232440 13626 319149 22628 16842 22612 11651 11652 11450 15077 66310 140858 97064 52615 19646 213464 74068 101867 210510 74691 57746 214162 98558 13001 83456 13000 330890 100039026 72634 17869 71981 245688 13206 17864 66715 22601 94244 57749 83561 23808 11520 78757 108099 12477 18607 18027 18029 21414 20823 21416 18032 231051 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 229906 235459 194388 24074 18140 83602 58202 68153 74197 22289 67923 27224 27632 27273 24116 12455 72949 13716 63856 11461 22059 15278 21780 16475 67278 23945 101739 16890 52463 17765 14055 14245 21652 74016 103968 16468 320727 208595 214133 103551 67800 11770 21803 54188 11545 15519 54196 19384 69257 13709 12143 18507 12400 225207 20674 192119 23992 53424 21357 22099 22065 12606 18761 22631 22629 18976 433759 16590 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 29813 59092 12575 22059 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease 14389 14172 80857 110279 14180 14178 14177 67112 64654 14175 14174 14173 14164 68705 98053 66420 69833 67710 245841 69920 20022 76007 14182 327826 20020 231329 20021 69241 17749 100043714 14184 67384 18176 14183 20662 15461 244373 21848 18708 18706 68092 433702 20851 20850 75296 360013 432508 67529 13047 20846 14388 20848 18803 80903 14186 14165 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 96%9769726 Defects of Coagulation cascade 14067 19123 14723 109821 22371 14061 14161 22021 14069 56316 19128 14058 14071 105722 14724 22022 54368 110135 14729 99571 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy 100756 17966 18412 19305 67443 667035 22190 13819 11920 SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 96%9842640 Signaling by LTK in cancer 74769 56430 18708 18709 26413 26417 18706 NETRIN MEDIATED REPULSION SIGNALS%REACTOME%R-HSA-418886.3 Netrin mediated repulsion signals 210801 13176 22253 18208 107449 20779 19247 107448 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade 66105 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 11909 26419 12675 16476 18033 18035 18036 11820 12234 56480 54131 19697 21402 73086 16150 16151 192656 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 80750 223664 107607 69721 231130 270151 11596 22059 67454 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 19766 11797 56532 22030 12475 22031 56489 225471 11796 106759 21353 18034 71648 54123 434174 100041766 14082 66513 93765 66589 19247 22034 66724 68652 20111 216080 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC 12469 12461 12464 22327 22152 227613 22153 22142 11461 22146 14976 67199 18637 67951 73710 22145 12465 545486 12466 22147 109054 21454 56612 12462 22151 12467 12468 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 96%1428517 Aerobic respiration and respiratory electron transport 68267 69089 226139 100042811 107029 27418 70456 74125 15929 16833 226757 67105 76282 109801 16832 381511 68263 228026 12857 18604 236900 27273 68477 75387 11429 18004 66089 68033 27402 68636 12856 110323 106557 18597 18598 382051 12861 319518 16828 66771 55951 76425 12862 59003 12974 109264 12868 235339 66142 12866 67264 12865 100041785 22273 66694 100042918 66576 14297 67530 544717 56046 100040287 13382 333182 380840 17711 22272 66152 624814 75530 67267 66821 56384 100900 72795 107197 66445 110826 67003 68202 380975 670717 11739 17992 229211 227112 225887 72900 57423 226646 17995 66477 595136 623286 66706 11958 235169 11957 78330 67899 210582 170718 11947 66359 52469 11949 66349 76916 68055 69802 75406 17705 67834 11946 269951 15526 66945 73694 66043 66343 11950 66072 66841 100041835 94281 100039108 66052 432676 64384 67680 228033 66925 110842 74316 70207 231430 20930 66271 67876 66690 76826 69702 66278 208501 54405 17991 66091 14194 69487 108755 66272 239760 56451 68015 20916 66414 20917 67388 71238 68332 66379 68472 104130 75597 66928 18115 22333 15159 68493 76947 67044 67273 68198 56705 66495 68002 67130 66416 68375 66108 52892 66836 212933 68342 76178 66377 68197 227197 67184 100042503 66046 230075 66916 66218 14874 14719 14718 70316 17436 18563 17721 17722 17716 17717 17718 17719 12858 76187 98314 217666 110446 20463 18293 78920 667035 22190 26940 17708 17709 17710 84682 22227 22229 22228 20523 74011 71803 67863 78830 50799 17449 17448 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 20163 109711 21754 19303 170736 57342 73341 TYROSINE CATABOLISM%REACTOME%R-HSA-8963684.5 Tyrosine catabolism 14874 15233 234724 15445 14085 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling 13866 13649 18183 83961 100042150 12223 18176 20662 13874 15461 15200 211323 13645 IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) 17874 53791 266632 GSD XV%REACTOME%R-HSA-3814836.4 GSD XV 14936 27357 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-HSA-1799339.4 SRP-dependent cotranslational protein targeting to membrane 622534 238217 16785 666669 100040021 13200 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 20818 107513 667618 66256 100040970 20832 267019 67437 56040 66661 67248 217337 100040331 24067 67941 27058 66384 20813 72265 57294 66286 67398 69019 56529 667035 66624 20014 103963 57743 76687 53421 27207 100043039 67097 670832 66212 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 96%198725 Nuclear Events (kinase and transcription factor activation) 21990 56437 14066 17095 12570 20393 15902 15901 17172 20408 15903 14283 211770 16478 17936 73086 107932 17937 11838 13656 13655 381677 26416 17258 26413 26417 21406 19712 19094 73699 110651 20112 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 13654 328572 20807 21770 14282 13653 13712 15904 16477 17260 17261 23939 20111 11909 13430 12569 12568 RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 96%5625900 RHO GTPases activate CIT 67268 67938 17904 11848 13385 11852 11853 17880 381293 77579 19353 71960 233406 17886 19046 329251 12576 17931 12704 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 96%211897 Cytochrome P450 - arranged by substrate type 320997 13120 631304 13118 72054 208285 64385 21391 19223 13124 13121 13075 244209 20181 20186 13123 104086 13122 102294 68165 14149 14148 13087 13116 13107 13115 13106 110115 622127 56050 11624 18984 11622 13082 13081 72303 107141 17977 13088 13077 13072 56448 13076 13114 232174 13079 74134 11529 17978 72082 546726 13110 13113 71519 545817 106648 100040843 13078 13070 11863 11864 18976 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%5652084 Fructose metabolism 230163 235582 16548 225913 20322 11668 11677 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production 72162 17874 54123 18033 13211 19697 18034 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.5 Cardiac conduction 235281 269717 11931 14226 20266 11932 20265 11933 11937 11938 65973 53313 109305 56188 76757 16514 56461 109552 67972 20271 11941 399548 18160 320707 20272 230103 381290 20274 53419 12322 18159 20273 12323 108058 110876 97064 12325 20192 20269 20191 72821 20866 110880 110891 20190 229709 16438 16439 13400 20264 18747 11928 98660 232975 20541 57780 18125 110893 16440 59095 20928 108017 21954 54378 12288 14169 15257 14168 14167 14166 56808 12295 12296 70357 80334 16520 14463 16518 15258 640703 16515 54377 81905 16529 210741 241769 16526 16527 223604 16535 21388 18091 74571 22063 72258 16528 230899 104158 16506 16493 17380 16508 56543 217826 16511 211480 332396 100986 52150 16525 16530 81904 18519 57814 246133 66240 16509 57442 24046 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors 436440 233079 233080 233081 107221 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 96%9026527 Activated NTRK2 signals through PLCG1 18212 78405 18803 12064 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%438064 Post NMDA receptor activation events 12326 14811 18039 216963 14810 11472 20779 19087 19084 23859 14814 52163 14813 12322 12323 108058 12325 26413 26417 18747 100039592 13385 53310 13383 110651 18176 20112 15461 108099 18607 14799 241113 19088 55984 19108 19417 19418 19353 211323 432530 14800 20111 640703 105787 11514 108079 14812 64011 19079 18749 207565 108097 19082 67071 19085 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665737 Drug resistance in ERBB2 TMD JMD mutants 13866 59079 12539 15519 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-HSA-9034793.3 Activated NTRK3 signals through PLCG1 18213 18205 18803 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins 73711 22088 67123 330192 667035 22190 66914 18108 107305 72543 194309 52348 ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 96%187015 Activation of TRKA receptors 18212 18211 11516 11517 18049 11540 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9831926 Nephron development 16371 22431 13388 16449 22417 21410 22412 16372 16869 18993 15378 16848 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 22608 100042305 208117 59287 100039623 18131 19164 19165 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK 241113 56717 12283 20869 64930 66508 545987 54170 72149 22084 52187 68576 66096 83409 74370 68441 19042 268706 105787 69008 108079 227154 19079 245670 108097 108099 19082 56716 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%350054 Notch-HLH transcription pathway 232232 20602 21372 18129 18131 18128 333639 79221 18132 270118 81004 170787 15185 70315 15184 15183 20185 12914 56233 14534 18519 208727 19664 433759 15182 103806 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation 18027 18029 20823 18032 21374 67065 71752 74414 233863 66420 72308 69833 66596 227644 78929 245841 66653 544971 77634 70239 20841 18986 269252 102209 26939 330959 67486 75627 70408 20018 69870 70428 67371 17749 218832 100043714 67005 20016 98488 12909 TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules 68267 117591 114479 27416 239273 114304 107568 13340 269346 63959 110157 11518 19298 13830 18673 52466 15129 15368 15122 11806 238055 18552 18550 18553 11428 18174 242341 68775 74591 53945 15369 11416 30926 27421 76252 20521 11972 108664 54403 66290 20538 67634 238384 18002 26569 14325 246787 117167 22232 640703 11964 23985 26357 72027 110935 13487 11966 74104 100039636 20501 66335 104245 11973 12215 11974 20516 15203 18670 74915 14319 28253 338375 170441 21871 11666 71279 73834 317750 12870 24059 114143 66237 11975 22041 54411 27060 64602 16819 140494 22042 20505 50765 142681 15216 20531 66144 71902 59049 270669 73649 100434 94249 213603 76376 242259 75750 66397 70129 68682 226999 63993 236794 331004 77031 236727 105243 277973 110895 20544 14697 14710 14699 66066 14700 56453 14708 14706 14704 14695 20537 14693 20526 64337 13162 14709 14701 18400 16891 14702 100017 30924 68453 14696 103161 93835 100102 57875 67963 19088 11307 105847 22259 18453 16956 65969 11303 11771 104110 11772 66113 71770 232345 13909 20519 218203 18671 20520 320024 22359 223920 11657 432530 11807 210044 11808 104111 18145 20652 14688 16816 17777 56636 624219 15450 76483 232910 11773 11812 16835 224129 11813 11814 11512 11425 11513 110611 11514 208677 11515 54135 18749 171504 16889 19085 11931 14226 11932 11933 11937 11938 65973 53313 56188 76757 16514 109552 67972 11941 320707 69597 381290 66865 12322 381038 12323 66815 108058 170756 12325 68115 20192 68514 20191 12034 22334 110891 66592 20190 70484 22333 27377 57138 216001 20498 22335 20499 78506 18747 20495 215999 11928 20497 11640 98660 20496 69029 232975 107723 234847 20541 73078 57780 110893 59095 20928 108017 268512 218756 231583 76408 11833 13521 73836 235504 27376 20528 108652 57274 80879 20525 20503 13723 11998 12000 17250 74610 56199 214111 56325 224814 19299 69847 27403 75607 11305 279561 224742 208169 11304 11944 77706 11945 217262 382427 192663 27219 217265 69047 27404 11981 56535 11977 26874 101772 117160 170759 170755 11979 14628 54670 241118 11419 74772 50771 212989 319767 102566 404545 229277 338370 26372 224079 140475 13665 50770 67204 105722 226144 382014 231287 26905 14605 268878 11980 20278 78339 67331 235574 193670 217843 54197 320091 58176 229782 66388 56315 252972 103098 20276 53896 20277 56774 242607 232341 70377 14411 56365 30962 76295 20532 233246 216440 215113 26373 216225 67760 12728 50934 12727 209837 12725 20513 12724 21366 97086 20514 12723 215335 243634 11989 23844 234967 192113 55963 74446 69354 50769 74338 24115 76257 58170 20511 99663 20510 233979 102680 320940 66753 20512 229933 20540 54667 67819 330836 11982 72401 12733 246049 105355 17254 116891 11987 214663 20338 105727 20539 26570 67075 27801 67470 27409 80286 19084 269523 76184 53869 11832 64008 12638 244373 11815 19879 28250 20533 230582 266690 320635 12346 242960 72017 12349 12351 11826 19743 30805 108052 27411 67473 67582 70840 242126 56327 68428 56384 69048 23943 239436 11739 433923 11740 216227 27410 67300 12757 231999 20393 19087 11816 22348 228368 233836 239606 24060 53881 15567 232333 14412 11519 242585 236792 243616 11828 11829 114644 11830 72621 11831 320718 20518 74340 20517 338365 225579 100604 56356 330064 214112 66333 65221 18399 56643 241296 83429 233280 100561 230612 11840 52635 59033 243755 72267 214922 380836 208760 11732 106947 434203 114886 58807 94229 240215 20529 21762 20500 22123 12752 353169 435818 19179 171429 19181 93790 19182 79554 23996 17919 19184 241612 74998 26440 30791 19166 58246 14977 19167 108115 231549 26441 272636 237831 26442 26457 69077 72002 66997 107566 23997 223473 20536 56436 77701 17463 20535 57296 13829 20422 19729 26445 18716 26446 227394 19172 70701 19173 212555 19175 64452 109342 19177 67547 21402 101488 55961 26443 243328 26444 12007 208890 19170 225997 12780 226781 22063 18173 193034 232156 66413 22065 22784 26965 22067 17189 667035 22066 230810 22190 28240 433926 22068 20515 63873 13358 59029 171382 106957 171166 20504 67089 56407 20502 68667 22782 70247 277328 98396 64177 72045 22260 17364 213053 246788 17339 68279 227659 94178 74552 22368 227059 226025 212980 194352 64242 26946 11827 56843 58800 27360 14664 140919 240332 83814 20527 56017 71803 67863 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 96%194315 Signaling by Rho GTPases 12387 12550 56324 20779 56374 15239 381293 20867 12389 83669 20844 76804 18844 108670 12874 59009 232339 107746 14786 223881 208994 26416 108686 66922 227937 20257 67586 71228 26413 68187 26417 93840 11671 327826 22325 77480 19094 54401 57257 246710 50875 29875 20662 19877 15381 83946 106504 52666 109331 16800 11465 263803 12848 52428 19230 13605 17920 270163 22352 20166 19878 236920 76626 26403 13830 56381 16480 19655 68743 53382 20874 15516 213498 70804 100043806 12704 269061 243362 26891 110596 56320 207212 109711 19285 12539 71704 20462 234094 69288 11464 242202 50768 56349 54216 16801 11852 404710 13367 75547 103573 20868 268301 17978 320795 109333 72754 208846 69632 213649 24001 224014 230098 53972 15369 30938 66508 442801 226970 235611 54126 101497 269608 640703 14163 26382 268739 14674 73341 11853 16906 54411 105827 22627 195727 210293 50884 71709 22042 83767 170758 329165 109934 106952 12532 71893 26934 110279 330177 75409 105855 242687 216963 386750 17969 20947 212285 237038 70497 320634 27061 77579 11308 71960 20619 224480 11856 16885 13058 16886 241275 13171 13057 108100 76117 218952 26431 17970 101314 17972 66898 71302 71544 13385 12261 14251 12385 14252 67784 76709 73178 12229 56443 78514 17827 80987 68089 68653 67771 11867 26554 56378 226525 66713 74117 13542 245880 13544 13543 22376 215280 68524 67299 223701 330319 76884 66894 223870 19249 12576 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 217866 19052 105782 73804 14269 19053 22379 51792 80837 20877 214459 381318 14467 66871 52696 226751 26886 76088 66934 218756 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 19418 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 21844 67052 232987 208869 12236 236930 107971 110379 69928 13427 76499 329251 13426 68458 52504 17931 13424 228421 236915 22342 16449 21873 13511 13510 109620 19299 58220 227377 15267 319168 319167 224105 319186 319178 319183 319182 259302 223666 14270 319190 117600 319176 319181 19353 20514 319169 625328 78303 319188 15270 16818 18750 624153 382522 18806 232440 319149 22628 22324 15077 269523 18710 17886 72565 74201 12988 67268 13206 55948 12638 18708 18709 18479 18706 18607 98386 101565 18481 16594 232943 16593 19354 20201 20202 74764 14609 12466 12468 22143 12461 18762 11848 102098 56513 68146 22319 11855 277360 192662 263406 11857 14570 68813 11461 19349 18805 624814 70584 68428 56418 56384 70361 233103 229658 544963 622434 100039786 16572 66251 16573 68202 16412 545156 16443 13726 23943 75739 140579 628438 71782 17207 94176 330662 94190 16709 52331 218581 84004 21917 56491 109904 238130 230972 20430 192176 223921 56419 380664 104445 56389 13836 59079 108037 23988 67938 69922 17904 223435 107589 330914 232906 56212 71435 228359 17283 17880 59069 19046 320271 99982 12345 14083 18016 76378 11352 53332 100039683 233406 17974 67300 17063 17925 14026 20740 214230 17973 20742 20663 241656 18643 18645 15519 11350 21927 74194 64652 216197 12709 20355 233877 22284 19229 51796 53817 69581 238505 75669 22637 213522 329366 56784 20401 233071 75974 12549 58996 66146 225326 214345 208263 192652 239027 70350 74159 71409 74018 106326 244867 70598 192192 319899 260409 57778 386649 226823 21763 18751 216445 69710 211499 244895 216831 268970 70719 328232 244418 101240 232201 73167 78816 228482 72729 104252 11835 231532 18753 68917 27360 69668 14218 71972 225358 214137 75415 171207 74734 71703 77038 228543 58804 56699 214804 269682 77006 223254 102075 66087 11736 23912 207425 19765 54004 20807 73910 83397 269401 434204 207495 76763 94221 11858 213783 13043 100038946 71085 545481 23853 210998 233489 219140 226652 14787 11854 232237 27984 75089 76577 20403 12631 22631 22629 76983 106628 18817 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9034013 NTF3 activates NTRK3 signaling 18213 18205 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis 22260 20181 20249 30924 14104 20182 268903 22259 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 11684 ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway 56436 17463 57296 20422 26445 26446 19172 19173 19175 12317 19177 16150 15006 26443 26444 16151 22319 20619 19170 17874 240095 66413 667803 667035 22190 59029 67089 14991 70247 117149 12491 21899 20193 14161 15007 12010 110135 99571 17087 16912 19171 12475 14827 16913 19186 12229 19188 434174 57743 21898 21354 22320 21356 21355 53421 20909 20201 100043039 20202 66212 20333 21762 22123 12675 19179 19181 19182 23996 19184 26440 19166 19167 26441 24088 26442 21897 69077 66997 23997 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 96%9034015 Signaling by NTRK3 (TRKC) 16367 19280 18213 58202 19277 20779 18176 20662 15461 18205 12028 18803 18708 18706 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432040 Vasopressin regulates renal water homeostasis via Aquaporins 14702 14696 11998 19088 12000 11828 19087 19084 11829 104110 14697 14710 432530 14699 210044 66066 104111 14700 14688 18747 14708 14706 14704 53869 14695 11827 224129 11512 14693 11513 11514 64337 11515 14709 18749 17919 74998 14701 11826 19085 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants 14255 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes 14828 226641 18044 18045 11911 12317 18046 13198 22027 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints 29870 12534 22628 70620 12566 240087 12545 54401 55948 12428 17216 17215 17217 17218 17219 17220 12544 319152 12427 21762 12442 22123 19179 19181 19182 23996 19184 26440 19166 19167 22627 26441 22390 26442 69077 66997 12530 23997 56436 12532 27214 17463 57296 23834 20422 26445 26446 19172 70024 19173 19175 268930 19177 26443 26444 19170 66413 667035 22190 59029 107823 67089 68251 20184 70247 269582 70681 70238 100039786 27223 107976 210766 22059 59004 15204 19360 17535 21975 319186 27354 319178 12021 319183 319182 81601 50883 327762 319190 22427 19718 69263 15574 11920 319181 12189 50793 18392 235610 18393 231724 66634 237911 26428 19355 26429 56452 225182 93765 26909 235559 12144 68275 106344 72151 68240 19891 22631 19367 19356 22629 12649 78303 319188 15270 382522 MITOPHAGY%REACTOME DATABASE ID RELEASE 96%5205647 Mitophagy 22241 56480 67443 71648 67526 11793 66734 72018 18412 66105 245860 667035 100041766 22190 66410 93765 22334 66589 22333 22335 66169 13001 28185 100043869 13000 100039026 53333 66119 22195 67414 50873 170731 223696 68943 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling 22324 26413 229709 26417 14360 16438 16439 22165 22325 16440 57257 17096 18176 20662 15461 17444 18708 18709 18479 18706 18607 74769 26400 26398 26420 26414 640703 19055 19056 26419 19419 18018 18019 21762 22123 19058 12675 108723 18021 19179 19181 19182 23996 19184 16476 18033 26440 18803 19166 18035 19167 26441 16822 26442 69077 66997 23997 16428 12234 14389 56743 56436 17463 21682 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 12042 66413 26965 667035 22190 240354 59029 26409 67089 103583 70247 26401 14127 14126 14125 14281 224105 234779 19353 20963 12229 100041766 216150 66513 93765 66589 18761 22034 19395 66724 233046 68652 216080 G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint 12534 12428 12427 268930 12442 22390 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 20201 20202 11909 26419 12675 16476 18033 18035 18036 24088 11820 21897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 21899 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 22030 12475 67245 18034 12229 434174 66513 93765 66589 22034 66724 68652 20111 12703 STABILIZATION OF P53%REACTOME%R-HSA-69541.7 Stabilization of p53 17248 56436 17463 26374 57296 50883 20422 228829 26445 26446 17246 19172 19173 19175 19177 26443 11920 26444 19170 66413 667035 22190 59029 67089 70247 12578 22059 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 96%6806667 Metabolism of fat-soluble vitamins 68453 65107 67442 15530 67861 11806 238055 11816 16956 665270 103978 71707 63857 17252 55938 105349 14733 69568 27973 22139 11807 239393 11808 15529 11603 23888 20971 79235 20969 16835 14734 170752 11813 11814 69060 77337 109791 83702 19662 14725 71951 20970 19660 16971 50500 14735 19659 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 96%1227986 Signaling by ERBB2 20459 59079 12539 11848 56424 18183 83961 100042150 84092 20779 12223 76890 13367 22612 11651 13874 11652 15200 211323 14786 19248 667035 22190 19253 18754 14360 67588 20416 15519 13866 13649 18753 75717 18176 14388 20662 17179 15461 18803 13645 18750 18708 23797 18706 MRNA POLYADENYLATION%REACTOME DATABASE ID RELEASE 96%9770562 mRNA Polyadenylation 54196 15381 19655 269061 70616 68598 67959 20462 107701 68092 72047 74326 67500 433702 75956 622469 225027 67996 22608 212880 71713 233073 83486 20382 110809 23983 18521 83701 20383 68479 20222 66899 108014 69207 100040029 319322 19205 27967 107686 76936 384091 666609 24128 216578 68981 20639 229279 68705 20641 98053 667035 101943 20638 22190 81898 66420 69833 67710 20646 245841 69920 67332 20022 20020 231329 20021 69241 17749 100043714 15382 170791 53379 20630 56258 14105 59013 20637 98758 53607 11991 70044 56070 67039 72459 56194 15388 100336 15387 52040 66055 67465 236732 19045 67958 76479 19046 13211 75062 13204 51810 76938 13207 233908 66125 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 74320 68188 54188 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) 110006 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME%R-HSA-9022538.2 Loss of MECP2 binding ability to 5mC-DNA 433759 20466 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9968551 Regulation of GBP-mediated host defense 18712 12362 55948 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis 21803 11740 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation 110826 640703 667279 239706 67099 72096 71974 320204 70511 269523 73582 207965 13629 68043 16588 15481 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway 104110 14680 224129 432530 11512 11513 210044 11514 104111 11515 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 50493 23971 23972 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis 216820 228061 14712 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9022707 MECP2 regulates transcription factors 17260 268859 19016 PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling 18576 11652 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844455 The NLRP1 inflammasome 12043 195046 12048 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 96%68949 Orc1 removal from chromatin 56436 17463 67177 57296 23834 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 12566 19170 66413 26965 667035 27401 22190 59029 67089 70247 12428 17216 17215 17217 17218 17219 17220 50793 18392 18393 66634 26428 26429 56452 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance 20873 15161 68121 76260 81896 12534 69940 78887 16570 12326 71769 107338 21821 22628 76411 277939 225745 241950 231123 66482 654470 67590 74360 73242 238799 18536 109181 26416 13196 68259 66296 214552 59030 74201 18541 76568 29857 66061 16568 213081 213575 67161 19889 19094 53869 71909 140810 237222 52028 67378 93730 102774 74025 17997 12879 67978 264134 18005 215445 73738 68475 53598 208518 67694 108099 380718 100041639 19014 67286 229003 11655 236266 20607 78802 106633 244585 12009 99100 103733 319845 22154 74470 21372 104318 109151 101565 110350 16328 17977 18763 18764 19017 260305 76779 16579 83922 17978 71492 59035 245866 81004 216363 66993 26370 17260 17261 70461 15183 20185 217166 74343 12914 382056 56406 11909 640703 75387 20656 21454 12462 22627 27373 12469 12461 12464 64436 18582 68146 227613 22153 22142 22145 12465 319757 670717 15278 21780 19088 208595 227112 17827 57423 68653 66477 76614 224904 11958 11957 68117 230935 216821 11947 66075 11949 433771 68055 68316 17705 11946 269951 15526 66098 66043 11950 53375 100041835 100039108 432676 64384 228033 75786 15519 18747 68097 51792 56455 16559 219103 76707 13589 18472 232987 170826 13427 13424 226153 50776 216151 381760 212541 20181 19013 26379 18181 14390 68346 14661 226169 100986 241113 12589 56350 77048 230376 69654 52906 60525 17274 18000 73668 67661 75296 53413 75465 15185 72421 224481 72140 106840 67344 67068 219072 11843 20336 56297 225659 107371 72938 53885 207911 76478 320299 329795 78177 16569 217935 27078 28135 214444 76816 108079 74019 217335 19079 54130 105504 108097 74682 211446 72569 18817 71820 381644 102058 109242 19082 67042 233649 73916 12789 382090 232944 231214 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%446728 Cell junction organization 233833 16451 20665 12388 232440 19089 12387 13200 13626 12550 319149 20586 20779 13858 15077 104836 13345 19303 12558 21417 52615 19646 26413 26417 21418 22325 13001 13000 100039026 17869 245688 18109 209462 18810 22160 16480 16452 22330 66357 109711 224619 66286 228839 18550 18553 69019 93759 226970 73341 56529 12476 12695 224912 56217 13017 13016 16456 20683 93742 56513 68794 20163 21754 170736 74202 57342 218952 16202 225341 12821 16412 330662 56198 140580 192176 77630 11492 239096 11797 12385 59058 110751 12564 15426 66624 16201 330914 20613 12552 57875 15227 11798 54721 99982 76687 228913 11727 217734 99011 11735 19645 22323 12330 20901 60611 16601 114142 12741 16600 53325 17246 16193 12555 93760 13430 12561 21762 22123 19179 21844 19181 19182 64945 67956 23996 71740 19184 105837 18033 58235 26440 19294 19166 94332 71908 19167 15220 60363 26441 54420 58187 26442 54419 69077 12738 66997 93737 23997 54725 56863 12737 56436 75677 17463 215654 57296 320873 20422 12565 24136 26445 241201 26446 12563 19172 53624 19173 12562 19175 12739 15376 19697 12740 19177 12560 12557 12554 26443 56492 26444 16195 22431 19170 621628 21423 18759 14694 192897 75339 66413 330222 192173 667035 56173 22190 239857 16403 242653 239931 59029 230738 18746 16194 67089 76007 56805 70247 58220 21406 237979 21885 58998 18554 227485 18417 227377 114141 16780 75234 16782 15267 319168 16774 319167 13040 13030 76850 239528 319186 319178 319183 319182 236511 319190 319176 319181 19353 20014 213988 103963 217351 214150 69038 13135 20583 14056 18717 17454 319169 57377 20848 625328 78303 319188 15270 433759 624153 15182 16430 14376 382522 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism 100043429 14725 22337 100017 13115 13081 19141 244209 59004 14473 65969 22196 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME%R-HSA-9636003.2 NEIL3-mediated resolution of ICLs 234258 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions 15170 54353 19261 19229 668101 19247 16423 22177 23880 14083 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME%R-HSA-8932505.1 DAG1 core M3 glycosylations 13138 215494 217734 74653 99011 97884 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay 78893 13682 52846 13681 231464 108077 230594 234594 214290 218343 56422 68106 218693 69305 103135 72587 104625 228140 66362 109075 66583 27998 50783 72544 67678 50911 234699 69639 24127 72662 66094 66446 69125 18983 13209 227715 319618 74108 67207 70640 75901 78651 27756 353190 225929 66373 58184 75705 13684 66317 208643 53621 72068 232791 192170 18458 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-HSA-420092.5 Glucagon-type ligand receptors 14702 14696 14527 14526 381853 14607 14697 22354 22353 20287 14710 14699 66066 14700 22355 93896 14688 14708 14706 14704 11516 14695 14652 11517 14693 64337 14709 14701 14602 14601 DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 96%9734195 Defective APRT disrupts adenine salvage 11821 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding 18207 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 96%4085023 Defective GFPT1 causes CMSTA1 14583 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 96%5603029 IkBA variant leads to EDA-ID 16151 18033 18035 19697 12675 16150 18034 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 96%9709570 Impaired BRCA2 binding to RAD51 12021 81601 327762 20422 19361 22427 19718 69263 15574 11920 12189 12190 235610 231724 237911 19355 225182 26909 235559 12144 68275 106344 72151 68240 19891 19367 19356 19360 17535 21975 27354 INHIBITION OF PKR%REACTOME%R-HSA-169131.8 Inhibition of PKR 19106 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764725 Negative Regulation of CDH1 Gene Transcription 232440 24136 13626 319149 20586 22431 21423 15077 13345 75339 192173 21417 52615 18746 19646 26413 76007 26417 56805 21406 21885 245688 15267 319168 319167 22160 319186 319178 319183 319182 20613 319190 319176 319181 228839 99982 93759 228913 20583 14056 319169 67956 625328 78303 319188 15270 433759 13017 13016 15220 15182 624153 382522 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163767.6 PP2A-mediated dephosphorylation of key metabolic factors 18639 19052 21770 19053 51792 73699 58805 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 96%9665246 Resistance of ERBB2 KD mutants to neratinib 13866 59079 12539 15519 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression 216848 232440 319149 667501 107932 20019 15077 21340 21339 21341 64424 22130 75316 81898 66420 70333 69833 11461 66136 245841 20017 19646 234366 110052 17749 245688 100043714 93762 23942 22385 17192 15267 319168 319167 229542 319186 328572 319178 319183 319182 319190 319955 18432 110147 319176 21374 319181 56200 56637 116871 116870 20018 14534 20016 319169 18519 12417 625328 78303 319188 15270 433759 15182 624153 382522 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9630221 Defective NTHL1 substrate processing 18207 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 96%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 20459 11848 232906 140579 18176 218397 19353 12927 15461 330662 19303 12928 140580 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 96%417957 P2Y receptors 67168 574402 78826 74191 18441 78134 18442 233571 235036 140795 70839 57385 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis 20322 11677 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%425407 SLC-mediated transmembrane transport 68267 117591 114479 114304 13340 269346 63959 11815 18174 53945 11416 19879 20521 28250 54403 20538 238384 26569 246787 22232 640703 23985 72027 13487 20501 104245 12215 20516 15203 28253 170441 71279 317750 12870 24059 20533 20505 142681 20531 100434 94249 213603 76376 30805 242259 108052 75750 27411 70129 226999 67473 68682 236794 67582 63993 331004 70840 77031 242126 236727 105243 277973 110895 20544 56327 69048 20537 20526 13162 18400 239436 11739 433923 11740 20519 20520 56636 216227 109552 170756 110891 70484 57138 20498 20499 20495 20497 20496 107723 20541 110893 22348 233836 228368 239606 53881 24060 268512 218756 231583 15567 232333 14412 242585 13521 243616 73836 114644 72621 320718 20518 74340 235504 20517 27376 338365 225579 330064 65221 18399 56643 83429 100561 230612 59033 243755 214922 20528 108652 106947 434203 57274 58807 80879 20525 94229 20503 240215 13723 20529 20500 353169 435818 171429 241612 30791 58246 14977 108115 237831 26457 72002 107566 20536 77701 20535 19729 11998 227394 64452 109342 67547 101488 55961 243328 208890 226781 18173 232156 22784 230810 214111 20515 13358 106957 20504 20502 22782 98396 72045 213053 227659 227059 212980 14664 140919 240332 229782 103098 53896 56774 242607 14411 30962 20532 215113 216225 67760 50934 209837 20513 21366 20514 215335 11989 234967 55963 69354 74338 76257 20511 20510 102680 20527 20512 20540 330836 72401 246049 17254 11987 56017 214663 105727 20539 26570 71803 67863 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 96%5358752 CTNNB1 T41 mutants aren't phosphorylated 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 SCN4%REACTOME%R-HSA-3282872.4 SCN4 68401 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559585 Oncogene Induced Senescence 17248 233833 15901 236511 20683 17246 211586 13555 19645 21781 12571 12567 213988 13557 13875 242705 217351 667035 214150 22190 100043858 12580 26413 26417 12579 12578 23872 23871 17454 22059 76850 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 96%9821993 Replacement of protamines by nucleosomes in the male pronucleus 319178 171506 319183 319182 74319 319190 319181 20815 625328 78303 319188 15260 15270 328440 319186 19119 382522 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation 640703 18575 18574 18573 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9031628 NGF-stimulated transcription 21990 328572 56437 14066 20807 17095 20393 12570 15902 15901 17172 20408 15903 14282 14283 16478 211770 17936 13653 17937 107932 11838 13656 13712 13655 381677 15904 16477 17261 21406 11909 19712 13430 100040260 14281 12569 13654 12568 C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine 56417 110532 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 96%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 13138 217734 99011 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways 12388 12387 58194 12550 20408 12402 56324 20779 15239 20404 17295 19720 20844 20405 13858 104836 667035 22190 19349 18126 26413 26417 71514 15519 55932 16211 14917 70686 26395 170761 26396 12527 50493 18571 12363 12010 17002 236573 15516 15129 109637 17075 15122 672511 12721 16646 26400 13806 26398 15200 18550 233405 100041766 108664 18655 640703 56216 20980 606496 64176 22317 271457 64051 22318 20614 13035 20979 20907 24088 75209 13629 14469 17533 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 96%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 13038 241196 12400 67296 13039 12702 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8931838 DAG1 glycosylations 216395 13138 75847 243853 98388 68273 67843 108902 215494 228366 217734 74653 24060 268510 246179 99011 16795 97884 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME%R-HSA-9005891.5 Loss of function of MECP2 in Rett syndrome 18747 81004 640703 20602 433759 12326 21372 56310 15183 20185 20466 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 96%1482925 Acyl chain remodelling of PG 18778 18783 226856 271844 18779 66586 237625 26971 99010 210992 26970 26565 18784 18782 78390 66350 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function 19682 19771 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance 232440 208084 14156 72171 245474 214987 22589 214901 20174 68964 72107 108689 69535 66181 12566 216853 68147 16881 13163 66420 69833 67710 52530 245841 21752 69920 20022 20020 18969 231329 18968 20021 69241 17749 19075 100043714 19076 28113 15267 101185 319168 319167 69745 319186 319178 319183 319182 327762 12428 269400 319190 22427 57321 19687 19718 319176 69263 319181 319152 56505 21749 497652 21750 18538 105522 12144 68275 106344 72151 18971 67857 68240 18972 19891 319169 12427 52036 67967 625328 78303 319188 15270 624153 382522 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME%R-HSA-167246.4 Tat-mediated elongation of the HIV-1 transcript 68092 433702 20922 20833 68705 98053 13871 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 58202 17420 67923 12572 27224 13872 27632 20924 24116 23894 12455 14884 13716 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) 217826 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%198693 AKT phosphorylates targets in the nucleus 56484 54601 58988 56458 15370 23797 11651 11652 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones 270669 14828 226641 18044 18045 11911 12317 18046 13198 22027 56453 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 269523 100043755 66105 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 105083 68098 24015 67923 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 56436 17463 57296 75452 20422 77987 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70247 217365 78913 213753 22230 66855 66244 76788 52231 100041766 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 216080 672214 66481 225058 71745 100038875 100038991 68028 100043000 67891 100043295 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9953170 GBP-mediated host defense 110606 18712 229898 55932 18550 11465 12362 14272 11461 55948 14469 225467 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-HSA-6785807.8 Interleukin-4 and Interleukin-13 signaling 16451 17161 12575 12443 11651 16153 16186 56468 21417 18126 15519 12491 17869 11799 15251 16189 16163 22352 22160 18708 16452 12609 15368 17395 18386 17392 20293 12702 14462 16190 83995 17984 16477 16165 16164 14086 19885 18413 15481 17210 16193 69581 15234 53314 56484 100038891 12043 16819 12048 257630 14103 11687 56458 20292 20674 14173 16364 20299 18390 16194 20210 19225 11689 16412 19883 16409 22329 22059 16776 16878 14128 21938 16411 14268 16160 16414 16176 16159 21926 14281 12053 22027 16803 12843 16173 16453 54721 18712 16175 20852 13609 16952 15894 18986 74145 16171 17390 209590 21857 20846 17829 21803 20848 18976 22339 12703 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME%R-HSA-190827.4 Transport of connexins along the secretory pathway 14609 14619 14618 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%381753 Olfactory Signaling Pathway 258299 258381 258992 258486 258650 258487 257884 18367 258991 258736 258097 258794 52250 258857 259111 258836 258821 56858 258542 258405 258935 258420 258321 259036 259034 259119 18324 258697 258432 258675 258673 64337 258677 257905 258334 258025 667918 258832 258469 258882 258601 258853 259112 258657 18366 18328 258470 258600 258338 258455 259053 258027 56015 259041 258573 259049 258563 259013 117004 258846 258105 329460 258854 258930 258281 257962 258387 18314 259063 258896 404315 258453 257883 104111 258586 258869 258587 14688 668825 258363 80706 258362 257909 258575 258358 258658 258616 258941 258944 258618 18369 258216 258866 258580 258582 16825 228228 258160 258267 258350 258544 258772 258640 258608 259015 404329 259110 546747 258636 259109 258715 259014 16870 258395 259051 258680 259045 258155 259100 258154 258805 258147 257916 258572 258990 18313 258749 258340 18331 259097 258036 258355 404318 259047 258980 259004 258407 259017 259019 170639 258371 259113 258656 258562 436002 258424 258752 18365 258939 258961 258268 258305 100038859 100043474 259074 258507 258427 259122 257917 404346 258819 258672 259075 259040 259058 258746 57251 258614 258700 258694 258478 258443 258178 258222 258775 14680 258352 258248 258831 258196 258458 18315 258776 259054 404317 258720 258985 258690 258373 404222 18317 258717 258937 668035 259071 258292 258531 258756 258238 258710 259106 258322 258946 258975 258763 258325 258536 258925 258924 258706 404331 258302 258804 258713 239766 258270 258704 259147 18343 18310 258310 258303 259115 259012 258357 258347 259035 258296 258179 259066 258206 259095 259092 244187 258098 259089 258163 224055 258914 258319 258759 258609 257898 258287 258506 258922 258316 258354 18346 259002 258814 259067 258620 258207 18341 18357 18330 218066 258016 257972 29849 258729 545140 258769 257985 258075 258515 258439 258271 258408 13591 258153 18312 258481 258318 258275 404319 258151 258933 258039 18322 258908 258702 258703 258659 243634 233649 12789 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog 81896 77583 21821 19087 19084 269523 68525 16568 18747 59056 213081 74239 104346 230500 20747 237222 74126 66313 109689 216869 380718 106633 244585 110350 103978 245866 214498 21762 22123 14634 14633 19179 19181 19182 23996 19184 75788 26440 19166 19167 26441 26442 69077 66997 23997 12234 93687 56436 17463 57296 20422 26445 26446 19172 11491 19173 19175 19177 21402 56438 26443 26444 19170 66413 19206 26965 667035 22190 59029 67089 70247 110355 20423 16396 13363 22158 319757 70300 271639 240888 14632 380614 66573 214240 71742 19088 226861 76857 18453 216440 104110 73668 67661 56637 432530 210044 104111 66753 16147 26554 116891 20338 14451 224129 57810 15245 11512 117606 11513 11514 18222 11515 18749 74682 24069 73916 19085 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection 15368 16173 66824 216799 19697 69146 12495 12499 18034 12267 16175 19200 54483 12266 18438 16176 12362 18033 18439 22166 67955 56338 13035 23959 15516 HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 96%1483115 Hydrolysis of LPC 74182 192654 232889 18783 329502 66857 78390 271844 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors 12767 17202 17201 22044 22045 13617 13615 246691 16963 208188 229214 140498 56183 212108 19773 242093 58182 381489 239336 104443 16336 224065 23919 319239 14289 14419 12772 12774 12768 80901 225642 56744 20607 59289 12776 14829 12775 12458 21333 12773 11606 12771 11607 12061 18386 12062 18389 23925 216749 21338 14064 20293 14063 14427 14062 14061 18166 21337 23832 18167 21334 18168 21336 14294 12424 14293 12425 12426 217369 227717 14065 12765 227288 280287 24111 56838 100043254 237362 385643 433292 246313 19156 20605 19065 20606 50501 19064 67405 211578 18216 54615 12145 12209 20609 20608 114229 14428 15171 13051 110312 18217 217212 387285 208990 230777 14767 22439 68039 18101 11820 57349 17171 30878 623503 107522 17329 20290 18429 17200 11998 18155 18430 55985 54140 20303 26361 109648 20304 12000 20306 20296 20292 20302 20295 20297 100039973 100038965 20299 56066 18387 20311 18390 20312 20300 18610 20210 18619 15139 252837 66102 12266 330122 20310 14825 14429 11609 23796 319430 12777 226278 12766 226304 12778 381073 12273 75805 76854 12769 15199 230857 14763 54199 12267 20604 171469 12854 13349 16952 15945 207911 13616 13614 18976 17199 13618 20315 17203 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447041 CHL1 interactions 53870 213119 109700 16398 12661 11733 16412 18186 15481 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 96%453274 Mitotic G2-G2 M phases 20873 68121 56299 29870 12534 78887 12575 217653 13555 22628 100038822 225745 231123 12566 74360 13557 18536 56371 66296 214552 19646 18541 75786 15519 18747 21664 71909 237222 73699 17997 18005 19052 73738 19053 68475 51792 53598 208518 236266 15516 328572 12009 99100 103733 22154 12428 74470 104318 56455 101565 16328 219103 108000 259279 103573 83922 171567 51885 72415 26370 76789 72083 76707 233276 103768 74237 13589 18472 12427 21762 12442 22123 19179 19181 19182 23996 19184 26440 19166 13427 19167 22627 26441 17931 22390 13424 26442 17865 72568 69077 66997 12530 231506 23997 12531 27373 629959 12234 56436 12532 17463 75660 57296 20422 26445 26446 19172 15366 19173 19175 268930 19177 21402 56438 26443 26444 227613 19170 72119 22153 66413 26965 667035 22190 22142 59029 67089 103583 70247 66671 17420 22145 12572 22059 14235 100986 16475 19088 230376 69654 231863 71648 17274 75296 72590 30949 77011 72486 19046 12537 77744 219072 225659 76478 78177 28135 214444 71978 76816 20878 54130 18817 381644 448987 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 96%418457 cGMP effects 58802 242202 23984 241489 18585 17540 18574 18573 72413 207728 16531 16533 19092 435726 16438 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8932506 DAG1 core M1 glycosylations 13138 217734 68273 99011 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases 319651 224836 56208 14479 107260 56324 84092 72607 15239 68031 21951 74493 22217 27401 170707 12005 235441 101206 22334 22333 22335 17869 217057 15925 327799 17125 15251 12638 17126 17127 84585 17128 100683 66313 109689 12006 17131 216869 76800 17248 30940 12428 17246 101565 22225 22284 14462 22224 107995 216185 21812 56505 68350 77125 28185 100043869 14534 12427 107986 71586 21762 230073 22123 108645 19179 19181 19182 23996 19184 19671 436004 26440 19166 18035 19167 26441 26442 69077 66997 12530 23997 56436 17463 57296 20422 26445 11555 26446 19172 19173 19175 19177 26443 26444 16151 100756 19170 66413 53376 667035 19211 22190 59029 26409 67089 24110 70247 269582 74270 71472 11835 22059 83563 66889 74112 30941 59025 216825 621893 22258 319162 15267 319173 74256 319163 319168 319167 319186 19766 11797 54198 319178 22230 319183 319182 14232 54601 22030 246103 69641 18970 319190 11796 319176 319181 66513 22034 59040 71954 50868 252870 319169 78303 319188 170822 235323 319189 74996 20439 382522 67561 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis 217262 192663 217265 56535 26874 11806 11307 67470 27409 27410 11666 19298 74591 19299 27403 11305 76184 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) 20497 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 96%6807505 RNA polymerase II transcribes snRNA genes 69917 93697 68991 192657 69882 72656 231571 20683 218333 71957 101861 70885 71793 225283 57432 70470 68705 98053 66420 56698 69833 67710 227644 245841 69920 77634 20022 20841 102209 330959 75627 20020 231329 20021 69241 17749 100043714 12572 20924 68092 21374 433702 20922 108143 68776 99730 107951 18986 21343 226182 12454 229906 235459 83602 68153 74197 12455 83701 72949 13716 63856 229543 70422 109077 68510 71177 18987 210925 109019 18130 75137 77065 269344 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 96%193692 Regulated proteolysis of p75NTR 100042305 208117 18053 59287 18033 100039623 11491 19697 22034 19164 19165 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111469 SMAC, XIAP-regulated apoptotic response 12367 670717 11783 66593 12371 11798 12369 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes 56636 624219 270669 30924 15450 68453 76483 57875 11813 105847 208677 16956 18552 18550 66113 18553 11808 56453 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling 18762 268980 20779 12443 11651 12389 11652 14697 18710 13610 14710 14699 12576 13983 66066 14700 26413 26417 15519 14708 14706 14704 13982 13649 14695 21802 14693 18176 64337 14709 15461 14701 20698 14281 18708 18709 18706 18607 14702 20807 17395 14696 17392 18127 12223 16589 71920 103573 13874 13712 15200 14678 14677 14679 14688 640703 17390 15469 14083 56484 16001 68268 12390 11839 17393 12043 102193 13645 23797 242851 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 96%9013973 TICAM1-dependent activation of IRF3 IRF7 54123 56480 54131 667035 22190 22031 56489 106759 21353 142980 71648 MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing 54196 15381 19655 269061 70616 68598 67959 20462 107701 68092 72047 74326 67500 433702 75956 64340 622469 225027 67996 225160 22608 51796 192160 331401 212880 71713 53817 233073 83486 625193 69823 20382 110809 23983 73666 18521 60365 83701 20383 68278 68479 70579 21681 73826 68134 66231 20222 66511 107829 66899 108014 192170 69207 19826 193116 66441 386612 17149 100040029 319322 19205 27967 107686 76936 384091 666609 24128 216578 68981 20639 229279 68705 20641 98053 667035 101943 20638 22190 81898 66420 69833 67710 20646 245841 69920 67332 20022 20020 231329 20021 69241 17749 100043714 15382 170791 53379 20630 56258 14105 59013 20637 98758 53607 11991 70044 56070 67039 72459 56194 15388 100336 15387 52040 66055 67465 236732 19045 67958 76479 19046 13211 75062 13204 51810 76938 13207 233908 66125 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 74320 68188 54188 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9034864 Activated NTRK3 signals through RAS 15461 18213 18205 18176 20662 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME DATABASE ID RELEASE 96%9636249 Inhibition of nitric oxide production 16211 18126 16646 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 96%380108 Chemokine receptors bind chemokines 17329 20290 55985 12767 20303 20304 20306 20296 20292 20302 20295 20297 100039973 100038965 20299 56066 20311 20312 20300 252837 66102 330122 16963 20310 14825 12777 12772 12768 12774 80901 56744 12766 59289 12776 12775 12458 12778 12773 12771 12769 20293 54199 23832 15945 12765 227288 56838 12145 13051 20315 57349 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis 15487 56348 18976 12640 57357 94224 15492 13074 15497 78925 16866 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 96%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 13138 217734 99011 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen 14723 279028 14724 54368 14729 22371 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate 11761 103711 216134 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 13077 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME%R-HSA-9907570.1 Loss-of-function mutations in DLD cause MSUD3 DLDD 12040 13171 13382 12039 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 96%350864 Regulation of thyroid hormone activity 107585 13371 13370 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 96%171319 Telomere Extension By Telomerase 67857 208084 245474 72171 269400 12428 20174 12427 52036 57321 66181 12566 28113 216853 101185 56505 68147 21749 497652 21750 52530 21752 105522 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) 12021 319178 319183 319182 81601 319190 19090 70620 319181 11920 12189 319152 22596 14375 93765 107823 68251 20184 240087 70681 70238 27223 107976 210766 55982 51869 59004 56626 56196 108138 78303 75570 15204 319188 104884 15270 319583 227525 19360 54125 17535 319186 27354 382522 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy 70686 19349 GASTRULATION%REACTOME%R-HSA-9758941.6 Gastrulation 21415 12387 12767 12550 16842 270118 18121 14182 21418 22601 21420 21419 94093 17126 17127 17128 103806 13395 23967 328572 17300 14234 21414 12159 21416 16869 18504 333639 22772 14463 18510 12914 14534 21762 22123 19179 19181 19182 23996 19184 19664 18999 26440 19166 100038891 19167 17863 26441 26442 69077 66997 23997 56436 13388 17463 57296 14472 18508 20422 24136 26445 225207 26446 18991 19172 18424 19173 20664 19175 14179 15376 21389 19177 18128 20674 14175 26443 14173 26444 19170 66413 59029 67089 70247 14106 20423 21679 21677 20613 13813 20671 20997 15227 14836 27217 14465 227606 22416 384452 17701 18509 84653 56184 17293 13389 16147 15375 18505 13838 18519 16848 22771 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter 21374 67065 74414 66420 69833 227644 78929 245841 66653 544971 77634 20841 18986 102209 26939 330959 67486 75627 70408 20018 69870 70428 17749 218832 100043714 67005 20016 12909 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME%R-HSA-9842860.2 Regulation of endogenous retroelements 216848 232440 319149 67155 20586 20588 20587 107932 70127 29861 269397 15077 243834 19708 232854 75339 67010 432769 268996 70650 12055 12054 11461 77045 21408 223828 19646 234366 12419 330890 72198 13435 21849 245688 22196 54343 100043429 23942 68094 17192 83796 77683 15267 83797 57376 319168 233060 431706 319167 244713 84505 229542 319186 434178 319178 319183 319182 319190 110147 239985 319176 74522 56456 319181 66993 116871 116870 93760 319169 237758 625328 54427 78303 100039610 319188 622480 15270 433759 15182 624153 382522 SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 96%9703465 Signaling by FLT3 fusion proteins 14389 224139 12575 20742 18176 20662 20851 20850 15461 18712 50490 109181 360013 14011 18708 76007 18706 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 96%397014 Muscle contraction 235281 269717 11931 14226 20266 11932 20265 11933 11937 11938 65973 53313 109305 11472 56188 76757 16514 56461 109552 67972 20271 11941 18160 399548 320707 230103 20272 381290 53419 20274 13405 12322 18159 20273 12323 19303 108058 97064 110876 12325 20192 20269 20191 72821 20866 110880 110891 20190 229709 16438 16439 13400 20264 18747 11928 67268 98660 232975 20541 57780 18125 11474 110893 21925 16440 21393 59095 50876 20928 21957 108017 233199 21954 17868 50875 50874 13346 17883 21956 17888 109272 21894 17885 17996 21924 21916 22352 21953 21952 21955 17901 17906 18479 17897 17896 54378 22330 12288 14169 15257 14168 14167 14166 56808 242202 12295 12296 70357 80334 16520 14463 16518 15258 640703 16515 54377 81905 16529 210741 241769 16526 16527 223604 16535 21388 18091 22063 74571 109700 72258 16528 230899 104158 16506 16493 16508 17380 56543 217826 16511 211480 332396 224105 17907 100986 216459 58226 12291 52150 239556 16525 11749 16530 67938 17904 107589 22004 434246 20410 26903 93689 17880 17898 54195 60596 59310 12391 16419 20411 22138 59069 234889 16952 11669 81904 18519 57814 246133 66240 12306 16509 57442 24046 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME%R-HSA-9865113.1 Loss-of-function mutations in DBT cause MSUD2 12040 13171 13382 12039 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME DATABASE ID RELEASE 96%8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 233833 213988 236511 217351 17454 214150 76850 239528 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9035034 RHOF GTPase cycle 54004 109711 223666 83397 14270 330914 207495 208263 71435 70350 228359 13367 12389 268301 22319 20619 11855 223870 11461 19349 68428 66898 229658 12345 23943 27360 75415 53332 218581 84004 16906 21917 17925 18708 71709 223254 18709 218756 56419 23912 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-HSA-9734009.2 Defective Intrinsic Pathway for Apoptosis 14103 12532 12380 12333 12261 22059 12334 12336 20656 56484 16476 69543 18477 21672 16906 22627 12569 12568 11820 99412 12125 12530 12578 12531 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 96%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 234130 73016 84035 56811 24117 74499 20319 20377 22416 22418 22417 216795 16974 13380 16973 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import 67892 636544 67264 66865 14297 22333 66821 100900 66445 73078 15510 18416 11739 11740 11692 69617 103172 66826 66531 66525 52815 56322 433806 100042179 17827 17714 68653 66433 66169 15929 28185 100043869 67105 21855 30059 71883 11947 14356 66075 30055 68185 11429 11946 53333 15526 68033 12856 30057 53375 21856 100041835 30056 66119 100039174 30058 66170 223696 78830 12974 50799 72170 17713 67713 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport 193813 270160 12068 70785 317717 235633 56494 192232 60409 211922 89867 67443 225870 58194 235416 329260 216131 69440 20408 67231 19328 12402 66890 12663 56324 217449 15239 20404 20844 20405 13858 12874 56044 117197 245638 27059 18457 224139 94245 80912 11777 170760 54401 20615 21987 232946 20661 77929 67804 69178 12848 17920 109689 216869 100043806 26891 15129 15122 56444 67665 22428 11806 13191 12121 76895 12344 238055 18476 59288 18475 105785 22365 64930 18002 14325 640703 22084 216705 14319 20980 18477 22041 22318 22627 20979 11820 99412 22042 26934 11555 12282 66397 69608 218811 320634 99683 20619 243764 77371 20334 56447 54161 12827 12826 12825 66371 68953 75608 208092 12836 66700 59042 100017 76877 17918 56395 14366 76709 73178 22418 105513 11771 11772 11650 71770 434174 56443 68137 11657 66913 68089 67771 56378 66713 232910 74117 11773 16835 50797 70349 12847 13543 16971 17913 54160 108148 66111 54399 75612 217615 192188 104015 73470 16563 234663 12491 20288 117158 77980 140792 71145 213827 17167 380713 11844 53334 68097 73804 14269 67511 56358 214459 14799 56455 26951 229841 75985 68938 228850 19325 68328 18472 57915 20528 210789 68365 74741 235661 18195 110379 13427 11839 19157 13426 13645 67474 19159 13424 19158 228421 72318 27277 73124 11998 12000 11699 15458 15439 16069 21872 240641 269152 16565 16564 16552 11891 16580 16581 67023 16561 16562 72772 16558 20210 70218 20932 75050 16554 286942 71116 16578 319991 224630 16560 11774 26754 241113 69654 71648 17274 19353 53413 11843 20336 107371 16569 68449 108079 381605 67046 19079 54130 100855 14423 105504 19341 108097 56486 211446 108995 77407 19337 269589 102058 74105 224617 19082 260302 235442 233204 17158 56715 103724 23797 19338 209815 93739 28169 22241 54189 227800 69940 66687 207592 16570 19326 70296 107338 106039 22628 215114 11651 66482 11652 53357 338366 93671 17886 109181 107305 72543 27681 70160 194309 52348 116733 73711 16568 22088 67123 330192 28084 76959 53869 66201 13649 20479 12500 21802 66914 55948 12502 12638 11801 269855 12504 53598 108099 104318 16594 668303 16579 232943 19348 216363 71819 16593 16551 110033 13047 209737 20202 74764 76932 73296 108123 108124 16004 74375 76332 16834 14609 226089 14619 76688 270192 19345 53611 271457 56367 19344 319642 102339 19346 98910 58244 70646 78304 338337 104303 17957 67542 78689 242406 56382 53330 228960 69834 224705 76899 245944 97484 68505 233824 54214 12662 232286 68299 22319 227746 70297 19349 56418 192187 70361 100039786 16572 66251 16573 16443 56389 66905 14615 14610 14617 20909 12343 12345 11842 12340 16571 319934 67300 13429 12757 20739 20740 74947 11733 11735 640524 20742 12317 20741 20743 11816 103967 80297 15519 15505 19339 11607 12223 71920 13874 20508 15200 21336 22320 26893 17113 14533 13423 11840 74325 26894 15481 67489 20955 11766 108679 11781 108011 215890 74438 105245 64138 13430 11782 26572 72685 26895 16334 74018 667035 22190 18783 110355 77038 11768 11769 108012 22027 11764 11765 11767 252903 12843 12842 14618 71693 20912 13132 13043 73094 229521 194590 210108 233489 80718 218503 30931 228998 18704 30934 14621 74015 225152 13854 353155 66691 17155 14613 67091 108800 17156 14612 20703 80708 230815 14611 66226 66616 14622 19324 240028 20616 14620 105522 20403 14616 243819 13855 14623 14067 231580 118454 69162 11845 75964 14275 67602 270096 12793 15463 217835 67857 18717 14569 100042773 29816 66975 20333 56017 14567 215474 218038 72433 207352 30948 227801 74498 13859 102442 22631 66682 320129 76954 52036 12492 106572 22629 76983 60510 19347 13032 269774 229541 245828 23969 72121 12794 20975 67790 240667 106628 72825 67727 14725 320714 214895 16197 216344 59005 55925 67844 14069 66147 20692 74760 78232 23970 245886 56041 170625 320560 333883 54609 329727 21787 56085 320435 27096 226407 72978 105841 227648 19330 76308 74030 76510 329877 100042343 209773 50907 192236 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex 27214 67177 23834 59001 57441 70024 17216 17215 17217 17218 17219 17220 12566 66979 12544 50793 18392 18393 66634 26428 26429 56452 12545 68275 18969 18968 68240 19075 19076 19891 18973 18974 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 96%5250958 Toxicity of botulinum toxin type B (botB) 20980 22318 20979 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 96%1614603 Cysteine formation from homocysteine 12411 107869 DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 96%5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 103988 103468 19386 231103 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants 234130 73016 84035 56811 13380 16973 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade 317677 71756 14134 12759 12630 17195 93721 12944 12273 11537 12274 16904 545366 12259 17221 71693 56373 12260 12902 12262 109828 12267 50701 14061 15139 14962 12263 12266 625018 22370 230558 333883 19128 319430 12258 110382 12478 12520 69379 12279 667277 50702 239447 12628 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 96%69190 DNA strand elongation 327762 14156 109145 17216 272551 17215 19687 17217 19718 17218 69263 17219 17220 78833 12544 69270 66634 16881 18538 68275 18969 106344 18968 72151 18971 68240 18972 19075 19076 19891 67967 69745 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway 328572 12914 56480 54131 15977 22031 56489 71586 230073 66641 71956 228607 217069 54123 DEFECTIVE B3GALTL CAUSES PPS%REACTOME%R-HSA-5083635.4 Defective B3GALTL causes PpS 66548 330267 207596 224697 56229 239337 77794 279028 108153 23794 30806 108154 210417 271127 229595 208936 77739 381694 269959 100689 233744 235130 240322 20357 11504 20356 18636 21826 226866 21825 240913 223838 237360 330119 216725 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 96%450282 MAPK targets Nuclear events mediated by MAP kinases 21770 73086 13712 26420 26414 17260 26416 17258 23939 26413 26417 20111 11909 19094 26419 73699 110651 20112 100040260 101568 235584 17164 67603 19052 319520 16476 72349 19053 51792 14281 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body 14725 100017 17250 54219 19300 68421 21452 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses 50917 27029 11881 15931 52120 110006 15586 27419 75612 15932 12091 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency 22017 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 20181 12012 20186 13123 93732 104086 17977 13122 77337 208665 101502 83702 13124 17978 26459 26458 15488 17117 170789 105349 27413 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%R-HSA-2474795.5 Diseases associated with visual transduction 242864 77974 79235 14539 19659 12057 22139 19682 11304 19771 20897 19662 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 96%1227990 Signaling by ERBB2 in Cancer 13866 59079 12539 13649 18183 83961 100042150 12223 18176 14388 20662 13874 15461 15200 211323 18803 19248 13645 18708 18706 20416 15519 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8849175 Threonine catabolism 15473 257635 231691 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex 13559 75660 104394 17187 23834 17869 211586 13555 21781 21973 433759 19650 19651 18538 19646 72568 12530 231506 629959 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-HSA-170670.5 Adenylate cyclase inhibitory pathway 14680 224129 11512 11513 11514 11515 104110 14678 14677 14679 432530 210044 104111 242851 TRANSLATION%REACTOME DATABASE ID RELEASE 96%72766 Translation 67895 13200 107508 269523 64658 66419 64660 78523 94061 623346 102060 50529 233870 100040519 68565 99045 66973 69163 20818 52443 107513 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 66286 232536 56280 66493 353242 67681 66399 64655 107733 68537 18100 67398 67707 94066 60441 218506 66230 68098 68463 65111 75705 74600 107734 69019 66242 13685 28028 13684 68735 622268 27398 94067 208643 28030 67840 68836 217869 79044 226982 94065 57312 67923 75398 68572 56529 67308 64659 56282 66292 24030 66121 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 56438 17711 217365 22230 66624 20226 57743 76687 53421 27207 100043039 67097 670832 66212 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 17705 20102 20103 668668 14853 667739 672214 66481 71745 225058 100038875 100038991 225363 68028 100043000 67891 18458 100043295 622534 14852 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 66105 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 66256 100040970 20832 267019 67437 56040 66661 67248 217337 100040331 24067 67941 27058 66384 20813 72265 57294 70316 108853 211253 320806 17721 17722 17716 17717 17718 17719 17720 105083 67871 24015 21762 67768 22123 67674 19179 19181 19182 23996 19184 26440 19166 19167 71941 70120 26441 381314 13629 67417 26442 67160 102436 69077 66656 74776 66997 55949 109093 23997 13628 212679 70560 56436 71984 17463 224805 57296 353172 75452 20422 70791 77987 26445 68915 26446 230577 19172 226539 19173 71807 19175 69955 244141 13682 19177 13681 27979 56347 26443 13669 26444 53356 68135 19170 55944 66085 73830 66413 16341 223691 667035 22384 22190 54709 100042807 98221 59029 66235 67089 70247 17708 17709 17710 13665 67204 108067 217715 26905 13667 209354 224045 78913 213753 66855 66244 76788 52231 20014 103963 100041766 107045 226414 97541 235606 239555 22375 216443 234734 107271 69606 27267 23874 105148 76784 70223 231872 76366 67851 66143 15115 110960 66590 22321 216080 104458 85305 13722 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-HSA-176187.4 Activation of ATR in response to replication stress 12532 27214 23834 70024 17216 17215 17217 19718 17218 69263 17219 15574 17220 12566 12544 50793 18392 18393 235610 66634 231724 26428 26429 19355 56452 269582 12545 68275 106344 72151 68240 19891 19367 19356 12649 12530 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME%R-HSA-9931530.2 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 12952 13001 13000 100039026 19047 104318 19045 19046 12568 18626 18627 18628 12953 27373 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF 17973 12388 12387 76884 18186 11651 12389 11652 22324 19303 26416 12928 216148 229709 14360 16438 29857 16439 15519 18747 22325 15507 19094 102626 16440 26415 57257 18176 19877 16416 15461 17164 78757 228775 19878 16480 18708 18709 18479 18706 18607 74769 18127 27371 230126 18481 19229 640703 14254 18803 16542 50884 83767 26362 329165 18762 11848 105855 242687 12562 17969 11308 13058 13057 108100 18751 18654 17970 101314 17972 18753 140579 330662 20698 224105 140580 75778 227290 20430 12385 56717 19353 12927 227743 14205 109270 245880 16410 218397 18749 14083 17974 18187 14257 22341 22339 22340 56716 18750 23797 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 96%888590 GABA synthesis, release, reuptake and degradation 232333 14412 14411 243616 268860 14415 14417 22348 214579 19339 13002 22318 20614 20979 20907 12889 15481 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702605 pexidartinib-resistant FLT3 mutants 14255 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME%R-HSA-9022537.2 Loss of MECP2 binding ability to the NCoR SMRT complex 81004 20602 21372 56310 15183 20185 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters 20536 74340 20535 232156 20533 94229 240215 218756 59033 54403 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-HSA-168928.12 DDX58 IFIH1-mediated induction of interferon-alpha beta 56480 74153 54131 19697 53323 100038882 16150 67526 11793 16151 66105 667035 225913 22190 20203 20210 54644 15519 26401 69721 270151 11596 71966 74256 21929 16396 12370 15516 19766 328572 56791 23988 22030 22031 56489 21353 18034 54123 434174 100041766 14082 22034 12914 28185 15977 71586 230073 66641 12675 18521 52440 71956 228607 217069 18033 216080 80861 18035 108086 18036 11820 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation 234779 26400 26398 19353 22324 26420 26414 20963 26413 26417 22325 26401 26419 57257 17096 18176 20662 15461 17444 16476 18803 14281 224105 16822 18479 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 106021 103468 19386 234865 59004 59015 22196 69736 100043429 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 96%380994 ATF4 activates genes in response to endoplasmic reticulum stress 72544 50911 69639 72662 64209 66446 227715 74108 70640 18044 11911 18045 18046 20293 12611 16006 226641 11910 12608 13198 66362 109075 66583 27998 27053 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME%R-HSA-168271.5 Transport of Ribonucleoproteins into the Host Nucleus 18141 107939 69482 71805 54563 16646 19069 70699 72787 18226 218210 69912 16211 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME DATABASE ID RELEASE 96%9816359 Maternal to zygotic transition (MZT) 78893 232440 319149 13682 52846 13681 192119 15077 231464 75605 100043167 230594 234594 547035 214290 22601 218693 22059 54196 21679 15267 15260 319168 104625 319167 228140 239528 328440 319186 19119 171506 328572 319178 319183 319182 69125 18983 319190 319176 319181 58184 208718 75705 216850 13684 12914 75467 208643 194388 18140 214899 74319 11628 319169 22289 56057 12193 382035 20815 53621 625328 78303 72068 319188 15270 232791 192170 624153 382522 18458 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling 56791 23988 56480 54131 74153 22031 56489 53323 100038882 67526 11793 66105 667035 100041766 22190 54644 270151 71586 230073 18521 71956 52440 228607 217069 74256 216080 21929 108086 16396 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases 12366 22062 268973 11783 12362 12368 12905 22059 57913 11920 22061 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC 12469 12461 12466 12464 21454 12462 11461 12465 12467 12468 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 96%194441 Non-coding RNA Metabolism 18141 107939 69482 71805 54563 107686 384091 19069 666609 68092 216766 70699 66069 621705 72787 20595 433702 18226 66603 218210 53975 12729 276919 20641 27374 20638 56698 70465 69731 432803 67332 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9833110 RSV-host interactions 16451 56208 54131 23989 20933 56438 100038882 170786 27061 59024 327987 667035 22190 70625 68975 234959 75613 381379 15529 11603 94112 23806 23888 20971 28077 70208 67219 170779 21899 19106 20969 171285 71951 20970 56771 80509 170743 14735 67224 19014 264064 142980 66999 76199 319186 328572 17087 56791 67279 15530 12475 17755 103978 54721 20847 69790 21898 14733 26896 15975 216154 246728 12914 51813 108098 15977 14734 67923 71586 69792 75717 230073 228607 217069 67381 13051 66172 192191 24088 78334 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing 19205 76936 68092 433702 68705 98053 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 15382 59013 98758 93686 77411 21843 21841 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex 93760 20586 20588 20587 56456 14025 68094 83796 19708 66993 83797 268996 57376 12055 12054 11461 77045 72057 58208 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-HSA-9933937.1 Formation of the canonical BAF (cBAF) complex 93760 67155 239985 20586 20588 20587 70127 56456 29861 269397 19708 83797 268996 57376 12055 12054 11461 77045 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%73863 RNA Polymerase I Transcription Termination 19285 667501 21374 21429 20019 21340 21339 21341 64424 22130 13871 75316 66420 70333 69833 66136 245841 20017 14885 209357 66467 20018 66671 17749 100043714 20016 17420 12572 13872 23894 14884 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants 16706 20779 12322 109880 12323 108058 12325 26413 26417 12988 109905 640703 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 16653 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 O-LINKED GLYCOSYLATION%REACTOME%R-HSA-5173105.10 O-linked glycosylation 71685 66548 13138 26887 330267 14426 207596 20448 108148 224697 171212 105450 56229 232984 353328 108105 239337 241391 68273 207839 77794 72297 233733 94192 108150 279028 212996 97440 654821 72077 271786 14537 67909 108902 74653 73068 216395 75847 21825 24060 243853 140703 171167 56336 56386 231727 268510 97884 227327 53625 80294 108153 70945 23794 30806 108154 16795 210417 271127 229595 208936 77739 381694 269959 14425 269328 98388 230145 100689 233744 235130 240322 20357 11504 20356 17829 18636 14423 67843 100039649 21826 140474 224116 215494 226866 228366 217734 20446 17063 20444 59048 20442 246179 240913 20443 272411 223838 231050 99011 78754 237360 20440 333424 330119 210004 216725 108760 73732 20447 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9026519 Activated NTRK2 signals through RAS 18212 15461 78405 12064 18176 20662 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%379716 Cytosolic tRNA aminoacylation 67895 353172 107045 226414 97541 216443 107508 22375 20226 234734 107271 27267 105148 23874 231872 70223 66143 15115 110960 66590 22321 104458 85305 13722 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 96%6798695 Neutrophil degranulation 53381 70450 12654 13014 102595 170813 14190 12796 76905 67912 53328 74244 71728 76025 229574 12508 12514 78892 68724 26949 232413 27261 433375 235627 26416 19074 19271 19263 72461 18103 17523 70152 26413 52633 217353 19276 69981 59026 667301 231887 109905 72042 69660 71869 72065 394252 100042069 78388 21946 23917 16970 227960 67689 18176 74287 29875 223978 19877 100037283 11571 208795 380924 13169 245126 20568 383295 215449 241197 67213 18813 83768 11846 13830 69189 16480 17025 13505 18703 268379 107767 15516 100040018 13244 22330 93726 54159 15129 16993 56318 55950 70536 17395 21930 100040603 56444 20195 212114 53856 18600 11593 74039 73690 13367 56016 18475 545878 20868 30960 16783 80796 54672 108888 17064 11605 56031 66222 96979 69550 13861 12283 20972 71517 69537 15369 381812 14667 66508 16678 545987 19264 80860 67862 66612 20409 74012 14325 19288 76299 66060 268373 14824 83409 100039636 108015 14319 22177 73834 26458 113868 11975 20614 27060 668218 16819 24088 71902 23845 12333 105855 68682 15006 20619 13058 13057 56485 19164 59287 17002 12182 58222 67963 26364 69146 50701 12267 53378 11772 434174 13205 67771 12798 66713 19342 17319 19336 70349 14191 15926 110006 109754 13035 15212 11676 14387 12091 11881 14131 66824 14595 18793 75612 14302 227753 110078 110095 12491 109154 18436 19340 15442 50917 74096 12505 66934 212032 56455 77559 71665 66681 231507 11758 70568 19325 68365 235661 266692 217303 67474 18641 13424 13629 19152 76507 18648 11487 17159 15439 13510 110173 18772 109620 11891 18746 27357 20932 11689 12266 16409 67781 16423 72157 16411 16414 232714 71884 50770 105722 232449 11674 11980 12475 225471 76295 19353 104112 18950 15170 71955 11717 235606 223646 11821 67075 67512 57437 108995 210992 216134 13200 66848 269523 20719 11886 18792 13001 14751 76501 16784 12238 22154 17394 16854 13036 226977 14293 20201 20202 12765 227288 240047 11501 74125 19156 16004 19345 19344 319642 19261 108078 19346 20343 57349 12469 12461 11848 227613 13010 19349 18805 22139 52588 668101 22072 544963 330122 232790 16498 17380 16790 94176 70495 52331 80910 52855 83382 20430 329547 56212 13350 13033 16592 57264 21858 12306 16410 18636 11783 69562 20740 56615 12331 193740 269116 72269 15519 16211 100037258 19025 19204 68197 14289 19339 13002 20813 18010 216197 22361 22320 100561 15481 105245 64138 21762 22123 19181 19182 54473 18033 19166 26442 69077 66997 23997 17463 227394 19177 19170 18173 66413 28240 216445 59029 70247 70719 11883 16408 69116 14127 18753 21938 13040 12010 13030 20716 12359 117586 11767 23912 14134 11537 12273 18613 76763 12512 72512 68891 22596 104009 14375 76577 20703 11625 20527 52120 14569 381809 106572 17474 13032 245828 333883 18407 19330 224794 67706 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 96%4570571 Defective RFT1 causes CDG-1n 328370 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport 81896 16570 56455 110350 12589 21821 16559 76411 76779 16579 73668 245866 67661 238799 75465 72421 109181 68259 67344 67068 76568 66061 16568 72938 213081 213575 16569 217935 74019 68097 264134 74682 71820 67694 100041639 67042 67286 73916 78802 106633 APAP ADME%REACTOME%R-HSA-9753281.3 APAP ADME 76408 14871 26357 231396 13106 394434 94284 14863 17250 20859 17960 71522 20860 207182 20887 12780 109652 14598 17961 23887 27416 239273 66054 394436 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 96%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) 13595 13360 74754 235293 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation 64658 66419 64660 78523 94061 623346 102060 50529 100040519 68565 99045 66973 69163 52443 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 67681 64655 107733 68537 18100 67707 94066 60441 218506 66230 68463 65111 74600 107734 66242 28028 68735 622268 27398 94067 67840 68836 79044 94065 57312 75398 68572 69606 67308 64659 56282 76784 66292 24030 76366 66121 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins 16922 15488 71767 113868 20280 11430 228061 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%5653890 Lactose synthesis 16770 20525 14595 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 96%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 328572 12914 246086 21410 14534 11925 18519 18128 333639 15379 15205 270118 19664 103806 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 96%111931 PKA-mediated phosphorylation of CREB 18747 640703 224129 19088 11512 11513 11514 19108 19087 19084 11515 18749 104110 432530 210044 104111 19085 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717319 brigatinib-resistant ALK mutants 11682 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis 20404 320634 12874 117197 245638 27059 18457 224139 94245 80912 11777 170760 20615 21987 232946 20661 77929 67804 69178 109689 11768 11769 11774 108012 11764 11765 11767 252903 233489 18704 22320 14533 11840 66616 15481 67489 20955 231580 14325 67602 108011 29816 105245 13430 216705 72685 108124 16004 14319 19345 22318 22042 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963676 Intestinal absorption 20537 20526 56485 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%352230 Amino acid transport across the plasma membrane 103098 53896 56774 14411 30962 20532 215113 67760 50934 209837 21366 20514 215335 11989 234967 55963 69354 74338 76257 102680 20540 330836 72401 246049 17254 11987 214663 105727 20539 26570 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B 14069 56316 14058 14071 14723 14724 54368 14729 109821 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-HSA-606279.3 Deposition of new CENPA-containing nucleosomes at the centromere 319178 319183 72155 319182 232440 319190 217653 20892 233532 100038822 70645 319176 66311 66578 319181 12617 83815 12615 18148 66570 56505 19646 70454 67733 71876 76464 245688 320394 102920 319169 60411 66336 93762 78303 15267 319188 15270 319168 69928 319167 26886 52504 624153 319186 382522 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME%R-HSA-5632927.2 Defective Mismatch Repair Associated With MSH3 17685 17686 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%9661070 Defective translocation of RB1 mutants to the nucleus 19645 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME DATABASE ID RELEASE 96%6791461 RPIA deficiency: failed conversion of RU5P to R5P 19895 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%975163 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 68652 17087 12475 225471 106759 108960 667035 21898 22190 66513 26409 22034 66724 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5213460 RIPK1-mediated regulated necrosis 14103 56532 14252 74568 12539 22030 108155 56424 21933 67245 11796 11798 53378 667035 71609 22190 14082 15519 14102 14251 18571 22195 22035 50873 16396 12370 19766 11797 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72163 pre-mRNA splicing 66053 66983 15381 19655 70616 68598 67959 20462 107701 67480 72047 68092 74326 67500 433702 75956 56031 80744 66101 70225 68879 320632 67418 212880 66585 22380 74351 54723 83486 19134 545085 66877 244672 238831 23983 24010 18521 20227 83701 74255 57905 67229 68479 70312 330361 66177 67050 209416 76522 72654 20222 28035 72886 18949 60321 66492 71715 215051 66618 230596 70052 70767 67922 66070 66381 77644 66810 108160 319322 100034361 66801 237859 19205 68592 27967 68035 217207 76936 67471 69757 68988 208768 71702 76793 22668 68981 67684 20639 209003 229279 227707 101943 81898 67439 94315 20646 192159 53317 15382 53379 56258 59013 98758 11991 11834 15388 15387 66055 68816 50783 67678 54633 66094 67465 69192 78651 27756 67285 66373 236732 67958 68183 76479 20624 66642 75062 27366 228005 28000 13204 100041953 76938 13207 233908 66125 64340 622469 225027 15481 67996 22608 51796 192160 71713 53817 233073 20382 110809 60365 20383 21681 68134 108014 192170 69207 19826 193116 66441 17149 100040029 107686 384091 666609 100040177 67010 68705 20641 98053 20638 66420 69833 67710 245841 69920 67332 20022 20020 231329 20021 72198 69241 17749 100043714 170791 20630 14105 20637 53607 56070 67039 72459 56194 100336 72935 13211 56215 51810 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 96%163125 Post-translational modification: synthesis of GPI-anchored proteins 76942 30060 228812 64931 170745 74762 18793 68311 230801 68404 330908 80883 26434 212518 72434 268890 14276 72585 23934 76768 53614 21684 13480 246190 69363 13481 72084 433931 329777 320772 668145 109979 72373 27392 76486 109978 269295 234700 14731 56703 57256 70325 232973 235505 12182 56746 68563 68453 68468 78928 66459 276846 244682 18700 67292 11647 110417 26464 71897 22361 11650 18701 18488 67556 17068 21683 71003 67133 14756 239827 327942 55981 237847 21838 235106 70163 241062 17069 320840 70574 114654 56047 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 96%9726840 SHOC2 M1731 mutant abolishes MRAS complex function 110157 17532 109880 19047 19046 11836 56392 54401 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus 22608 18011 13388 16449 240055 225164 11487 54485 13649 16450 18131 66894 21335 19164 19165 100042305 208117 59287 100039623 667035 76580 22190 13645 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism 56185 80911 111175 93732 74159 74147 171282 16922 11666 26458 12908 56794 15488 17117 113868 67131 67528 170789 26378 74114 110959 20524 74121 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 96%9757110 Prednisone ADME 100559 15484 15483 18671 12401 22236 11657 77337 13114 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 96%3560796 Defective PAPSS2 causes SEMD-PA 23972 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013424 RHOV GTPase cycle 13836 214230 17973 269401 101565 216963 56513 20742 22284 83669 73178 59009 59069 26431 244895 71228 70584 74201 58220 54126 229658 29875 75415 17974 218581 67300 228543 270163 26403 224105 18708 53382 18479 20740 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs 319178 233833 319183 319182 232440 236511 319190 319149 319176 319181 15077 66420 69833 320727 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 319169 625328 15267 78303 319188 319168 15270 319167 19384 624153 239528 319186 382522 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717326 crizotinib-resistant ALK mutants 11682 NEPHRIN FAMILY INTERACTIONS%REACTOME%R-HSA-373753.5 Nephrin family interactions 74769 109711 17973 11474 20742 11472 29875 12488 50791 73178 54631 170643 17974 12361 60595 67703 243911 18708 18709 14360 18706 20740 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.7 Choline catabolism 100434 30805 110695 68682 218865 12116 74129 192166 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 96%5362798 Release of Hh-Np from the secreting cell 103978 16147 11491 77583 214240 20423 13363 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 96%72689 Formation of a pool of free 40S subunits 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 27979 56347 19989 13669 76808 53356 19899 68135 100043184 55944 19921 66085 19934 73830 100043755 16341 223691 667035 54709 319195 100042807 100043209 98221 68193 66235 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-5649702.4 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 18970 382913 18294 22594 72774 16882 59047 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG 67800 116939 13350 23945 245532 66853 668257 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9024909 BDNF activates NTRK2 (TRKB) signaling 18212 12064 FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 96%217271 FMO oxidises nucleophiles 14261 55990 14262 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 96%937039 IRAK1 recruits IKK complex 16151 16179 93834 93765 67245 66589 240518 22034 12675 16150 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling 107568 667035 22190 16396 17999 20779 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 96%9703648 Signaling by FLT3 ITD and TKD mutants 14389 12575 18176 20662 20851 20850 15461 18712 50490 14784 12048 18708 14255 19247 18706 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-HSA-110329.4 Cleavage of the damaged pyrimidine 319178 319183 319182 232440 319190 57321 319176 319181 17193 234258 71726 319152 382913 18294 21749 72774 497652 18207 21750 319169 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%428157 Sphingolipid metabolism 11881 14466 244757 108105 17250 50935 58911 271970 11886 67902 225742 71949 26938 75292 545260 101540 67630 230379 239559 11883 53897 103236 76893 66190 19025 432628 74442 66183 14344 171168 14343 50877 74008 338521 77041 20773 67689 77626 26879 22234 14421 545975 14420 241447 104725 66844 56632 20698 19012 50784 56491 22239 20454 18760 238011 230101 433323 70059 208449 13244 54447 67260 67916 227102 268656 228677 18010 93898 242083 23956 223753 81535 70750 20397 76303 56336 56386 30960 20597 11605 17113 14667 66612 26357 66427 19156 20598 58994 54218 20444 70893 15212 15211 12091 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) 15931 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME%R-HSA-5083625.4 Defective GALNT3 causes HFTC 100039649 140474 224116 14425 269328 353328 17063 73732 17829 METABOLISM OF STEROIDS%REACTOME%R-HSA-8957322.4 Metabolism of steroids 17117 12640 13075 244209 16211 12012 20186 13123 104086 93732 57357 13122 77337 208665 101502 83702 19384 19014 229003 76408 13116 13115 14104 98386 110115 56050 21372 109151 17977 17978 59035 81004 66993 27413 13070 28250 64291 12914 56406 28253 26458 15488 170789 73166 231070 270669 110196 14137 100040592 20683 66397 18044 18045 18046 235293 68603 69608 218811 14732 13124 99683 100042622 20775 76205 20249 59045 235623 12257 192156 170459 15484 170439 20845 15483 72999 12401 13121 20788 13360 107476 100705 14593 16987 17764 56453 77371 20181 319554 22337 17855 19013 20334 59004 22196 68165 100043429 14149 14148 20787 19141 74411 74754 66234 14473 18194 110460 68865 13595 15490 100017 13081 94224 76303 13072 13074 71720 20494 15492 78925 228983 20493 15497 12642 106407 16866 65969 13079 15486 15487 330962 66065 26459 114664 170460 14187 99031 71240 105349 100273 11657 16204 56348 14725 15485 18976 11677 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%446652 Interleukin-1 family signaling 71481 211550 19249 19250 19253 104831 26410 19259 19256 16182 24058 331461 16068 320139 56294 19255 73914 26395 17127 16189 16163 16174 26399 69677 26398 18412 107527 26406 77125 54450 26419 215274 21762 22123 12675 17082 19179 19181 19182 54473 23996 19184 215257 18033 26440 19166 18035 19167 18036 26441 54448 11820 26442 69077 66997 23997 12234 56436 17463 57296 20422 56480 26445 26446 19172 19173 19175 19697 19177 21402 56438 16150 26443 26444 16151 19170 192656 17874 66413 16179 26965 667035 22190 59029 20203 26409 20210 67089 24110 103583 11689 257632 70247 266632 80750 223664 107607 69721 231130 93834 270151 11596 22059 16181 67454 240518 71966 108960 59025 16178 16176 12362 12370 16173 22030 19258 67245 69146 18034 16177 16175 434174 19248 66513 93765 66589 19247 22034 66724 68652 15170 20848 13035 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 96%9634635 Estrogen-stimulated signaling through PRKCZ 15461 18762 26413 18176 18607 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-HSA-191650.4 Regulation of gap junction activity 14609 21872 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 96%9830674 Formation of the ureteric bud 22411 17300 14573 20472 20563 19713 14234 12159 16412 15431 268902 241226 18504 15396 114249 109663 14585 23892 20471 14048 58198 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity 385643 58992 232345 16621 12258 94175 12261 16678 18793 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors 29813 53325 228829 209456 333654 22059 11651 11652 22061 18996 22062 18997 21981 23797 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 96%157858 Gap junction trafficking and regulation 14618 13132 21872 14621 225152 14615 353155 14610 14613 14617 14612 14611 74325 14622 14620 14616 14623 118454 11773 13430 14609 14619 67300 17920 13429 12757 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK 102098 20663 22324 277360 18049 22325 622434 545156 16443 12015 57257 20662 17207 16800 13605 109904 230972 213498 207212 71704 234094 223435 56349 16801 94275 19418 75547 19353 18053 72754 69632 213649 24001 224014 56321 230098 53972 30938 77669 442801 226970 54126 101497 269608 328967 14163 26382 268739 26419 14674 73341 21844 12125 236915 109934 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 96%3359474 Defective MMACHC causes MAHCC 67096 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking 14618 13132 14621 225152 14615 353155 14610 14613 14617 14612 14611 74325 14622 14620 14616 14623 118454 11773 13430 14609 14619 67300 17920 13429 12757 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 622534 238217 14852 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 68092 433702 19704 27207 67097 670832 633683 20044 27050 208643 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 14853 672214 66481 225058 100038875 100038991 68028 225363 100043000 67891 100043295 18458 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 96%9686114 Activation of inflammatory caspases 12367 16176 16173 640703 66222 12363 69146 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 96%190236 Signaling by FGFR 14172 80857 14170 19205 14180 14178 12402 14177 76936 67112 64654 14175 14174 14173 14164 83379 71436 109880 68705 98053 667035 22190 66420 69833 67710 245841 69920 26413 20022 26417 327826 20020 231329 20021 69241 17749 100043714 15382 399558 116701 396184 18176 59013 20662 98758 15461 19052 19053 51792 18708 18706 68092 24064 17346 433702 19247 14425 114715 114716 14388 21814 14181 67903 107971 72514 18803 93686 77411 80903 21843 21841 14186 14165 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 14067 19128 19123 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%182218 Nef Mediated CD8 Down-regulation 11771 11772 71770 232910 11773 12526 108664 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion 66355 13367 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 96%204174 Regulation of pyruvate dehydrogenase (PDH) complex 14874 381511 68263 228026 18604 236900 27273 75387 27402 18597 18598 382051 319518 13382 235339 CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway 12326 19088 55984 19108 19087 19084 104110 12322 12323 108058 12325 432530 210044 104111 18747 100039592 640703 224129 18753 11512 11513 110355 11514 18575 11515 18574 18573 18749 207565 18752 18750 19085 SIGNALING BY RAS GAP MUTANTS%REACTOME%R-HSA-9753510.2 Signaling by RAS GAP mutants 15461 16653 18176 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 96%381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 18508 66624 12387 14695 14526 21416 233081 66286 56529 18548 64337 16846 12591 225642 236781 76687 13482 107221 69019 242851 14688 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease 17096 22612 18176 20846 20662 20851 20848 20850 15461 18710 16590 16818 18708 18709 16452 14360 18706 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 96%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 12387 12550 56324 20779 56374 15239 381293 20867 12389 83669 20844 76804 18844 108670 12874 59009 232339 107746 14786 223881 208994 26416 108686 66922 227937 20257 67586 71228 26413 68187 26417 93840 11671 327826 22325 77480 19094 54401 57257 246710 50875 29875 20662 19877 15381 83946 106504 52666 109331 16800 11465 263803 12848 52428 19230 13605 17920 270163 22352 20166 19878 236920 76626 26403 13830 56381 16480 19655 68743 53382 20874 15516 213498 70804 100043806 12704 269061 243362 26891 110596 56320 207212 109711 19285 12539 71704 20462 234094 69288 11464 242202 50768 56349 54216 16801 11852 404710 13367 75547 103573 20868 268301 17978 320795 109333 72754 208846 69632 213649 24001 224014 230098 53972 15369 30938 66508 442801 226970 235611 54126 101497 269608 640703 14163 26382 268739 14674 73341 11853 16906 54411 105827 22627 195727 210293 50884 71709 22042 83767 170758 329165 109934 106952 12532 71893 26934 110279 330177 75409 105855 242687 216963 386750 17969 20947 212285 237038 70497 320634 27061 77579 11308 71960 20619 224480 11856 16885 13058 16886 241275 13171 13057 108100 76117 218952 26431 17970 101314 17972 66898 71302 71544 13385 12261 14251 12385 14252 67784 76709 73178 12229 56443 78514 17827 80987 68089 68653 67771 11867 59040 26554 56378 226525 66713 74117 13542 245880 13544 13543 22376 215280 68524 67414 70827 214952 229877 170731 67299 223701 330319 76884 66894 223870 12447 19249 12576 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 217866 19052 105782 73804 14269 19053 22379 51792 80837 20877 214459 381318 14467 66871 52696 226751 26886 76088 66934 218756 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 19418 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 21844 67052 232987 208869 12236 236930 107971 110379 69928 13427 76499 329251 13426 68458 52504 17931 13424 228421 236915 22342 16449 21873 13511 13510 109620 19299 58220 227377 15267 319168 319167 224105 319186 319178 319183 319182 259302 223666 14270 67095 319190 117600 319176 319181 19353 20514 319169 625328 78303 319188 15270 16818 18750 624153 382522 18806 232440 319149 22628 22324 15077 269523 18710 17886 72565 74201 12988 67268 13206 55948 12638 18708 18709 18479 18706 18607 98386 101565 18481 16594 232943 16593 19354 20201 20202 74764 73296 14609 12466 319642 12468 22143 12461 18762 11848 56382 102098 56513 68146 22319 11855 277360 192662 263406 11857 14570 68813 11461 19349 18805 624814 70584 68428 56418 56384 70361 233103 229658 544963 622434 100039786 16572 66251 16573 68202 16412 545156 16443 13726 23943 75739 140579 628438 71782 17207 94176 330662 94190 16709 52331 218581 84004 21917 56491 109904 238130 230972 20430 192176 223921 56419 380664 104445 56389 13836 59079 108037 23988 67938 69922 17904 223435 107589 330914 232906 56212 71435 228359 17283 17880 59069 19046 66905 320271 99982 12345 14083 18016 76378 11352 53332 100039683 233406 17974 67300 17063 17925 14026 20740 214230 17973 20742 20663 241656 18643 18645 15519 11350 21927 74194 64652 216197 12709 20355 233877 22284 19229 51796 53817 69581 238505 75669 22637 213522 329366 56784 20401 233071 75974 12549 58996 66146 225326 214345 208263 192652 239027 70350 74159 71409 74018 106326 244867 70598 192192 319899 260409 57778 386649 226823 21763 18751 216445 69710 211499 244895 216831 268970 70719 328232 244418 101240 232201 73167 78816 228482 72729 104252 11835 231532 18753 68917 27360 69668 14218 71972 225358 214137 75415 171207 74734 71703 77038 228543 58804 56699 214804 269682 77006 223254 102075 66087 11736 23912 207425 19765 54004 20807 73910 83397 269401 434204 207495 76763 94221 11858 213783 13043 100038946 71085 545481 23853 210998 233489 219140 226652 14787 11854 232237 27984 75089 76577 230654 20403 12631 22631 22629 76983 106628 18817 22346 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9632700 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 12571 12567 12578 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis 15486 66065 15485 114664 14187 13075 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9937848 CHD chromatin remodelers 232440 12387 319149 240442 13445 11538 269610 106795 22780 22779 78266 228880 52004 15077 17191 233410 11819 22778 140858 622675 70998 14121 19646 234366 16002 56811 245688 23942 17192 70802 101631 73503 12006 67772 328572 67959 109151 107701 72047 17135 20833 18104 18024 114741 22026 76246 71389 214498 12914 66317 212880 21413 235497 22083 17927 17928 54624 68479 20222 216848 14377 319322 27967 107686 384091 666609 12412 107932 68981 21423 20639 20641 101943 20638 81898 20646 67332 21406 22196 15267 319168 319167 66055 229542 319186 319178 319183 319182 67465 319190 319176 13018 72293 67958 319181 241128 320790 76479 75062 12648 244059 116871 13204 116870 76938 66125 319169 12417 625328 78303 319188 15270 433759 15182 624153 18534 382522 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 96%380284 Loss of proteins required for interphase microtubule organization from the centrosome 20873 68121 12534 78887 22628 225745 231123 227613 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 83922 75296 26370 76707 219072 13589 225659 18472 76478 78177 28135 214444 76816 54130 18817 381644 13427 22627 13424 27373 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion 18796 18797 14672 14682 18795 12671 14676 14675 17118 18750 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013700.2 NOTCH4 Activation and Transmission of Signal to the Nucleus 100042305 16449 208117 59287 100039623 11487 54485 22631 18132 19164 19165 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 96%3595174 Defective CHST14 causes EDS, musculocontractural type 12111 29873 121021 13003 13004 12032 13179 72136 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013418 RHOBTB2 GTPase cycle 51796 56320 12461 26554 109711 12539 20462 53817 246710 50875 15381 83946 106504 11465 12466 19230 17920 76626 19655 53382 15516 12468 15519 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 96%9764561 Regulation of CDH1 Function 56436 17463 57296 20422 12388 26445 12387 26446 19172 12550 19173 19175 19177 20779 26443 26444 19170 13858 104836 14694 66413 667035 22190 59029 67089 70247 13040 16480 13030 22330 12385 53325 17246 13430 21762 22123 19179 19181 19182 23996 19184 105837 26440 19166 19167 26441 26442 69077 66997 23997 VPU MEDIATED DEGRADATION OF CD4%REACTOME%R-HSA-180534.3 Vpu mediated degradation of CD4 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 26443 26444 19170 66413 667035 22190 59029 67089 70247 21762 22123 12504 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence 12571 12567 12578 NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 96%8956321 Nucleotide salvage 75894 18950 229665 15452 22271 109674 11717 57813 105446 11534 11486 11821 66355 13178 27369 21877 67365 80914 22245 68556 76654 72962 72269 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer 21803 21812 21813 17126 17127 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport 79554 56356 231999 272636 23943 12752 11840 52635 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME%R-HSA-5619085.4 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) 13487 ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 96%5662853 Essential pentosuria 67880 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1483249 Inositol phosphate metabolism 18796 18797 56409 18795 75678 102954 27399 271424 227399 71207 327655 320634 19211 269437 104015 16330 16331 16332 269615 18798 18799 72469 18802 217837 228550 74055 320404 19386 114875 104759 233011 170762 108989 231042 227699 223921 227720 445007 269113 66679 18141 107939 69482 71805 54563 76500 234779 19069 70699 72787 18226 218210 54384 210376 69718 17330 69912 103468 640703 234865 56727 114663 55980 71780 212111 59015 16329 69736 110379 18803 269180 234515 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders 19743 11998 117591 54140 26361 12000 63993 236794 15275 331004 114479 214111 20495 20497 107723 19386 231103 20537 20526 13162 228368 18400 24060 170762 108989 231042 227699 223921 227720 445007 269113 66679 18141 107939 69482 71805 229782 54563 56774 19069 13521 70699 30962 20532 72787 18226 218210 235504 18174 20520 53945 11416 74338 20521 20510 69912 54403 102680 20538 20512 238384 20540 103988 26569 246787 103468 246049 22232 17254 23985 72027 13487 216227 20525 20501 104245 234865 12215 20516 15203 28253 59015 170441 69736 71279 317750 12870 24059 110379 20533 20505 142681 20531 TICAM1 DEFICIENCY - HSE%REACTOME%R-HSA-5602566.3 TICAM1 deficiency - HSE 106759 142980 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 96%3371571 HSF1-dependent transactivation 328572 12914 81489 74370 56717 100043508 67605 68196 12322 80888 12323 108058 193740 12325 56716 14228 15516 12955 15512 15481 15499 15482 15519 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 18053 433759 18049 15182 15183 72843 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 96%189445 Porphyrin metabolism 394433 19044 70383 15368 14080 26357 17250 28253 12780 15288 22276 12892 17025 15369 11657 11655 11656 109778 14151 233016 226139 394436 22275 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism 18796 18797 18795 55979 19087 19084 238276 16514 58805 68465 11450 72674 20910 229709 16438 16439 18747 109905 12491 16440 73699 29875 19052 19053 51792 108099 12288 12286 12290 21770 14104 56808 12296 12297 20869 20525 233081 21351 22318 11551 20614 11553 20907 18639 240444 16334 21881 238076 14675 14697 12671 14710 14699 107476 66066 100705 14700 20927 14708 14706 14672 14704 14695 14652 14676 16500 14693 20526 268345 64337 14709 14682 14701 56508 223864 14702 14696 14527 14526 19088 50790 104110 74205 14678 14677 104112 432530 17118 210044 104111 21428 53420 14688 12289 224129 11512 11513 11514 108079 11515 18749 108097 18750 19085 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors 258299 258381 258992 258486 258650 258487 257884 18367 258991 258736 258097 258794 52250 258857 259111 258836 258821 56858 258542 258405 258935 258420 258321 259036 259034 259119 18324 258697 258432 258675 258673 258677 257905 258334 258025 667918 258832 258469 258882 258601 258853 259112 258657 18366 18328 258470 258600 258338 258455 259053 258027 56015 259041 258573 259049 258563 259013 117004 258846 258105 329460 258854 258930 258281 257962 258387 18314 259063 258896 404315 258453 257883 258586 258869 258587 668825 258363 80706 258362 257909 258575 258358 258658 258616 258941 258944 258618 18369 258216 258866 258580 258582 16825 228228 258160 258267 258350 258544 258772 258640 258608 259015 404329 259110 546747 258636 259109 258715 259014 16870 258395 259051 258680 259045 258155 259100 258154 258805 258147 257916 258572 258990 18313 258749 258340 18331 259097 258036 258355 404318 259047 258980 259004 258407 259017 259019 170639 258371 259113 258656 258562 436002 258424 258752 18365 258939 258961 258268 258305 100038859 100043474 259074 258507 258427 259122 257917 404346 258819 258672 259075 259040 259058 258746 57251 258614 258700 258694 258478 258443 258178 258222 258775 258352 258248 258831 258196 258458 18315 258776 259054 404317 258720 258985 258690 258373 404222 18317 258717 258937 668035 259071 258292 258531 258756 258238 258710 259106 258322 258946 258975 258763 258325 258536 258925 258924 258706 404331 258302 258804 258713 239766 258270 258704 259147 18343 18310 258310 258303 259115 259012 258357 258347 259035 258296 258179 259066 258206 259095 259092 244187 258098 259089 258163 224055 258914 258319 258759 258609 257898 258287 258506 258922 258316 258354 18346 259002 258814 259067 258620 258207 18341 18357 18330 218066 258016 257972 29849 258729 545140 258769 257985 258075 258515 258439 258271 258408 13591 258153 18312 258481 258318 258275 404319 258151 258933 258039 18322 258908 258702 258703 258659 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C 52120 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-HSA-5654732.3 Negative regulation of FGFR3 signaling 327826 14172 80857 14180 12402 24064 64654 17346 14175 14173 14164 19052 109880 19053 51792 667035 22190 80903 19247 26413 26417 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-HSA-110357.3 Displacement of DNA glycosylase by APEX1 17193 71726 11792 18294 18207 268395 DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 96%9675135 Diseases of DNA repair 12021 17685 17686 17350 81601 17688 327762 20422 19361 114714 22427 19718 69263 15574 11920 12189 12190 234258 235610 231724 237911 18294 19355 72774 57434 18207 225182 26909 235559 12144 68275 106344 72151 68240 233826 19891 19367 19356 19362 19360 17535 21975 19363 19364 27354 18861 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%561048 Organic anion transport by SLC22 transporters 18399 19879 20521 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 96%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) 28253 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 96%909733 Interferon alpha beta signaling 16451 54131 100038882 15006 16364 240095 667803 667035 22190 24110 14991 16211 19106 80876 23960 246727 56045 56417 231655 19246 15007 66141 16362 58185 70110 54139 57444 52668 16363 667370 112419 15958 16646 76500 24014 12702 13653 54721 16913 54123 16391 20847 69550 24015 19247 15975 246728 15900 15170 15977 20846 27056 12703 14469 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 72774 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME%R-HSA-5624138.4 Trafficking of myristoylated proteins to the cilium 19889 106840 56350 74025 12879 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes 22072 66473 93835 14603 19300 68421 65969 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%6784531 tRNA processing in the nucleus 67053 70047 208366 227522 54364 19386 19384 170762 108989 231042 227699 223921 227720 445007 269113 66679 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 67676 102614 69912 76265 68215 66637 103468 74097 68045 73192 68626 104721 117109 98985 66161 234865 381802 66078 108062 28088 67724 67106 59015 98404 69736 94230 54188 110379 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 16151 16179 93834 93765 67245 66589 240518 22034 12675 16150 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) 72027 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 96%5654228 Phospholipase C-mediated cascade; FGFR4 14172 80857 14170 14180 14177 64654 14175 14173 14164 83379 18803 80903 14186 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) 20540 17254 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%450302 activated TAK1 mediates p38 MAPK activation 68652 19094 107607 102626 26399 108960 16151 17164 192656 26397 16179 26416 66513 93765 66589 26409 22034 257632 66724 TCR SIGNALING%REACTOME DATABASE ID RELEASE 96%202403 TCR signaling 16428 12234 77647 56436 17463 57296 17973 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 192656 12042 66413 22323 26965 667035 19211 22190 19271 240354 59029 26409 16331 67089 103583 70247 12988 12500 12501 12502 12504 17444 224105 18708 18709 18479 18706 18607 74769 18481 234779 94212 100041766 216150 93765 66589 18761 22034 14969 19264 14968 68652 21762 22123 12675 108723 19179 19260 19181 19182 22376 23996 19184 18033 26440 18803 19166 216080 18035 16818 19167 26441 16822 22637 26442 16797 69077 14026 630146 66997 23880 23997 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371599 Defective HLCS causes multiple carboxylase deficiency 18563 78038 110821 66904 72039 107476 110948 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 96%176409 APC C:Cdc20 mediated degradation of mitotic proteins 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 30939 18005 12428 12237 107995 12427 56150 21762 22123 19179 19181 19182 217232 23996 56317 12236 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-HSA-1660662.8 Glycosphingolipid metabolism 11881 14466 244757 108105 50935 58911 271970 11886 67902 225742 26938 545260 239559 11883 53897 19025 14344 14343 50877 74008 77041 77626 26879 22234 14421 14420 22239 20454 238011 230101 54447 18010 23956 223753 56336 56386 20597 11605 17113 14667 19156 20598 58994 54218 20444 70893 15212 15211 12091 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 96%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 18408 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 96%9945266 Differentiation of T cells 216848 22632 232232 20602 18129 20586 20230 18128 79221 107932 16364 270118 170787 66310 140858 19646 234366 22022 213464 214162 56233 245688 208727 23808 12418 23942 16189 17192 16163 21926 17132 14281 103806 229542 12151 15978 328572 19763 21372 54383 13619 17283 333639 12399 241915 14462 16190 12416 20851 20850 81004 20852 15185 19821 70315 15184 15183 116871 20185 18986 116870 12914 23871 494448 14534 20849 18018 18019 18519 30951 16162 57765 53314 19664 16476 433759 16191 50794 18987 15182 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage 21877 67365 22271 80914 57813 22245 68556 76654 13178 72962 72269 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME%R-HSA-167290.4 Pausing and recovery of HIV elongation 20922 20833 68705 98053 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 20020 231329 12454 20021 69241 17749 100043714 58202 67923 27224 27632 20924 24116 12455 72949 13716 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 96%114294 Activation, translocation and oligomerization of BAX 12028 12122 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME DATABASE ID RELEASE 96%9846298 Defective binding of VWF variant to GPIb:IX:V 14723 14724 54368 14729 22371 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin 15461 15200 17392 13649 18750 18176 20662 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-HSA-6807878.2 COPI-mediated anterograde transport 17957 67542 12068 54160 56494 16334 11733 11735 107338 66111 640524 20742 97484 20741 54399 233824 20743 56418 80297 224139 234663 66251 56447 54161 213827 11844 53334 68097 67511 77038 53598 56358 56389 59042 56444 67665 22428 56455 13191 12344 59288 56395 69654 228998 68137 105785 11843 11840 19324 66913 14275 12343 12345 100042773 11842 235661 74498 12340 50797 18195 108123 108124 70349 12847 76332 54130 16834 56041 13427 333883 102339 13426 13424 99412 76308 338337 20739 100042343 20740 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 96%4086400 PCP CE pathway 56436 17463 57296 20422 11848 26445 26446 19172 19173 56513 19175 19177 57265 26443 26444 19170 18643 66413 667035 22190 18751 59029 67089 93840 70247 22411 20187 105782 22417 66313 216869 106042 14367 14365 14362 14366 19353 11771 22418 11772 14370 208846 71770 14368 19354 14369 74325 22408 232910 11773 13542 21762 22123 19179 13544 19181 13543 19182 23996 19184 75788 18752 26440 67300 26563 19166 26564 12757 22419 19167 26441 18750 26442 170758 69077 66997 23997 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME%R-HSA-4755579.4 Defective SRD5A3 causes CDG-1q and KHRZ 57357 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase 56808 54377 12295 12296 57814 246133 16535 66240 16509 57442 81905 81904 100986 54378 12288 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat 68092 433702 20922 20833 68705 98053 13871 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 58202 17420 67923 12572 27224 13872 27632 20924 24116 23894 12455 14884 13716 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%450341 Activation of the AP-1 family of transcription factors 26420 26414 16476 11909 19094 26416 26419 14281 26413 26417 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855196 IP3 and IP4 transport between cytosol and nucleus 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) 214111 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 96%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) 236794 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-HSA-2187335.6 The retinoid cycle in cones (daylight vision) 19661 20148 14539 12057 245532 19771 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d 208624 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619229 Activation of RAC1 downstream of NMDARs 19353 207565 640703 216963 55984 52163 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 96%1236978 Cross-presentation of soluble exogenous antigens (endosomes) 56436 17463 57296 20422 26445 16912 26446 19171 19172 19173 19175 19177 26443 26444 19170 16913 66413 19186 19188 17534 59029 67089 70247 246278 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 14129 17533 66997 23997 HIV TRANSCRIPTION INITIATION%REACTOME%R-HSA-167161.4 HIV Transcription Initiation 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2468052 Establishment of Sister Chromatid Cohesion 71988 71521 24061 100710 218914 67849 77805 20843 19357 13006 20842 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation 14702 14696 14527 14526 19088 19087 19084 104110 432530 210044 66066 104111 14700 14688 18747 14708 14706 14704 14695 224129 11512 14693 11513 11514 64337 11515 14709 18749 14701 19085 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%435354 Zinc transporters 213053 214922 227059 72027 106947 69048 67547 22784 30791 230810 14977 239436 106957 72002 22782 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia 394436 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 96%167238 Pausing and recovery of Tat-mediated HIV elongation 20922 20833 68705 98053 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 20020 231329 20021 69241 17749 100043714 58202 67923 27224 27632 20924 24116 12455 13716 FLT3 SIGNALING IN DISEASE%REACTOME DATABASE ID RELEASE 96%9682385 FLT3 signaling in disease 14389 12575 12402 20742 20851 20850 18712 50490 14784 14256 109181 667035 22190 360013 14255 19247 76007 224139 18176 20662 15461 14011 12048 18708 18706 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 96%389359 CD28 dependent Vav1 pathway 19353 22324 12487 12519 12524 16818 224105 18481 18479 14360 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events 17202 17201 20779 19087 19084 22094 12640 235036 18747 140498 212108 19773 381489 16336 319239 109689 216869 170458 19214 19222 19217 19219 14309 14308 100043254 14773 227289 17200 18576 11554 11998 11555 11556 12000 13492 382348 381853 14607 13488 14697 111174 215855 503558 54598 215854 19226 14710 15466 14699 11540 66066 14700 93896 14708 209512 14706 15566 22095 15565 12310 14704 14608 12922 15562 11516 16412 14695 23984 14652 241489 11517 12311 14693 110355 64337 218461 18574 14709 18577 18573 15874 110385 12921 238871 207728 16402 54611 12918 18584 14701 114640 223780 18583 54409 80910 19227 381413 19228 93690 56089 238725 213527 51801 71223 239530 14602 383563 14601 29863 11535 14761 14702 26385 14696 14527 76854 14526 19088 16866 16867 104110 14678 22354 14677 14687 22353 20287 14679 432530 210044 104111 22355 14688 70086 224129 320129 11512 11513 11514 11515 18749 18976 17199 11541 17203 242851 19085 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 96%5693607 Processing of DNA double-strand break ends 70620 12566 667035 22190 107823 68251 20184 240087 66131 269582 232314 70681 70238 27223 56420 50721 107976 210766 21853 59004 22196 100043429 15204 19360 17535 21975 319186 27354 12021 319178 319183 19822 319182 81601 327762 12428 319190 22427 19718 69263 15574 319181 11920 12189 235610 319152 231724 237911 19355 225182 93765 26909 235559 12144 68275 106344 72151 68240 19891 12427 19367 19356 12649 78303 319188 15270 382522 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades 17087 12475 22031 19697 106759 16150 18034 16151 17874 12229 434174 21898 20201 20202 266632 117149 53791 12491 21899 20193 12675 14161 18033 170743 18035 24088 21897 54445 110135 142980 99571 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 96%71291 Amino acid and derivative metabolism 21990 107508 13371 13370 70337 12389 19125 213696 114479 56189 107585 212647 12908 22094 214593 99439 13142 66811 106200 12640 70503 22018 11298 216343 15112 19193 11611 212503 217214 11898 50493 109900 227231 18408 18416 67824 11846 27053 100042811 72947 19301 93747 76282 100434 30805 229517 66885 12035 68682 12036 66948 58875 104776 12040 12041 13171 13382 12039 110695 218865 74129 192166 216456 22059 268782 21743 214580 20768 211006 50880 20226 14711 65967 75420 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 170442 20103 235386 668668 68133 56442 667739 192289 66194 71562 672214 69051 18478 23971 209027 66481 70266 23972 98256 225058 14204 209176 100038875 110391 11847 100038991 13180 100678 68028 66514 434437 100043000 53814 67891 12716 100043295 107766 622534 242669 238217 76722 54375 16785 26943 666669 12715 100040021 20810 67025 30956 100043391 230779 668182 671878 241053 75986 70789 432502 229905 56720 19989 194237 76808 217593 19899 108653 100043184 67432 19921 104174 19934 83885 100043755 102857 76238 27364 218442 319195 23923 100043209 20229 68193 209692 621100 67092 19941 574418 665189 270076 666899 12971 100042670 266645 107272 100039316 18247 22121 18242 18245 236539 56752 15930 18263 100043876 100043893 100043423 100042986 20115 107146 67281 76846 625646 100040298 68172 100042740 19951 15233 234724 15445 14085 667618 100040970 267019 56040 67248 100040331 67941 64918 246277 14874 66902 14261 12583 12411 57294 67870 211389 12709 12116 67873 243616 14719 14718 14645 66071 73748 107869 56369 104923 27376 246221 13166 211488 18948 22117 21823 56551 18104 13195 59010 226654 21762 22123 19179 238505 19181 11720 14660 19182 23996 210009 110446 19184 269378 26440 18113 19166 13190 19167 22293 18431 26441 22173 22178 26442 69077 66997 23997 56436 18293 17463 78920 57296 76507 78038 20422 71761 243382 26445 107239 227095 26446 15186 11992 19172 15109 72039 19173 243537 56357 19175 140483 67383 19177 14317 26443 26444 19170 66413 667035 59029 67089 70247 14431 104816 11484 269642 72560 240332 68346 14661 14411 234967 15108 15473 17254 107045 257635 226414 231691 97541 20539 216443 105148 231872 66143 20425 104458 78830 50799 85305 13722 RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription 56484 12399 12125 17127 17128 SIGNALING BY WNT IN CANCER%REACTOME%R-HSA-4791275.5 Signaling by WNT in cancer 225849 93687 26931 21770 26932 12387 21416 14367 72345 14366 22416 21951 74493 14370 56637 12005 14368 234130 73016 84035 56811 53627 73699 207742 19052 19053 51792 13017 13016 16974 13380 11789 16973 226849 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3311021 SMAD4 MH2 Domain Mutants in Cancer 17126 17127 17128 HCMV INFECTION%REACTOME DATABASE ID RELEASE 96%9609646 HCMV Infection 20602 13626 18854 319149 12412 15077 13163 107305 52615 72543 27681 19646 70160 194309 52348 116733 73711 22088 67123 234663 330192 28084 21849 245688 16412 19386 13649 66914 66371 68097 68953 621893 234852 75608 319162 15267 319173 319163 15387 319168 319167 170762 108989 231042 227699 208092 223921 445007 227720 66700 319186 269113 66679 319178 18141 319183 319182 107939 69482 12609 71805 319190 21372 56455 54563 19069 319176 70699 72787 18226 319181 13712 218210 105513 81004 56310 15183 20185 69912 103468 14056 235661 319169 234865 59015 69736 78303 18033 319188 110379 13427 319189 13426 13424 382522 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660499 Synthesis of PIPs at the plasma membrane 101476 320207 320634 18710 19211 19249 104015 16331 16332 67073 77116 30955 18708 18709 18706 108083 74769 18707 18718 18704 17772 216724 210376 11840 240752 18705 104709 18720 18719 68365 18717 97287 12169 20975 74302 19341 53332 219135 84095 319934 271457 240753 231999 109135 19062 269180 234515 83435 83436 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation 60599 12566 72119 667035 26416 22190 77976 13001 13000 100039026 19094 12795 22059 69181 20877 108099 19360 17535 21975 27354 12021 17248 17165 15257 81601 50883 23988 327762 12428 17246 241113 270627 22427 228980 19718 319944 69263 21374 15574 11920 20833 12189 216185 108143 235610 66464 231724 68776 237911 99730 19355 70439 20869 225182 26909 114741 235559 72504 15258 21343 12144 209361 226182 68275 106344 72151 24074 68240 19891 12427 19367 105787 19356 108079 20878 19079 63856 12649 108097 19082 12569 12568 76367 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling 242341 68775 76252 68428 11972 108664 66290 117167 94178 11964 110935 11966 100039636 66335 11973 11974 74915 338375 21871 73834 114143 66237 11975 22041 54411 27060 140494 22042 50765 15216 66144 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols 13116 110115 56050 11624 11622 17977 13072 13124 13079 17978 13121 13078 13075 13070 11863 11864 20181 20186 13123 104086 13122 102294 68165 14149 14148 18976 G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 75660 17187 12534 23834 12428 211586 13555 21781 12566 12447 21973 12448 19646 18538 13559 104394 17869 12427 13548 433759 19650 19651 17865 72568 12530 231506 629959 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 96%9006927 Signaling by Non-Receptor Tyrosine Kinases 20459 13448 11848 12402 18183 83961 100042150 12567 12443 11651 12566 12447 19303 667035 22190 12928 69710 12576 71514 13649 20218 13992 14815 170771 15251 140579 18176 15461 330662 19246 140580 232906 12223 12702 13874 19353 12927 15200 211323 13819 20811 66725 106766 93695 13866 75273 218397 20848 13645 DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 96%5579004 Defective CYP26C1 causes FFDD4 546726 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME DATABASE ID RELEASE 96%9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 107351 16542 14011 668218 54214 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 96%901032 ER Quality Control Compartment (ERQC) 193670 227619 54197 116891 20338 74126 66967 192193 223455 66597 320011 23802 22644 216440 66435 108687 75841 667035 22190 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%5663202 Diseases of signal transduction by growth factor receptors and second messengers 12387 20602 12402 74244 20779 17295 270118 109880 12005 26413 26417 20416 327826 109905 224139 56233 15214 54401 26395 26396 194231 54519 18176 29875 20662 245684 22371 15461 16416 75590 110157 23980 18218 14161 63953 21894 215449 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 328572 16706 12539 672511 21372 13191 81004 21812 21813 15183 20185 12914 640703 22084 14225 67605 15234 56484 16476 13017 13016 16542 66899 14011 668218 11789 12125 110279 18128 56438 13433 18595 70686 20423 14939 19164 19165 15208 100042305 208117 59287 100039623 56198 14235 18646 54167 232679 81910 13363 14367 14366 22416 54721 14370 14368 16147 18015 101809 114715 114716 23971 67561 12575 19645 21951 74493 12322 12323 108058 12325 12576 14255 14182 19047 19386 53627 73699 12015 12371 238037 19052 19053 51792 226849 225849 26931 21770 26932 17246 26420 211323 26419 56430 12608 12064 14388 18212 18205 107971 78405 18803 11839 13645 12048 67160 18011 13388 16449 240055 225164 11487 54485 11491 16450 16364 68705 98053 66420 69833 67710 245841 69920 76007 20022 20020 231329 20021 69241 17749 100043714 235584 67603 26372 56463 26936 21848 11774 330286 76850 67726 239528 100986 78781 19317 11610 76156 210106 66549 16905 236511 67095 14359 69923 338523 56717 216440 19353 75296 217351 56637 14256 214150 227743 19247 66753 104709 15170 116891 17454 20338 109270 20846 20848 606496 16818 56716 23797 78798 268980 13666 18183 215114 83961 320207 12211 100042150 19043 19084 22612 14025 11651 11682 11652 22324 12047 269523 18710 16153 17886 109181 14360 12988 234130 15213 73016 84035 17869 56811 13649 14184 21802 74126 207742 17096 244373 78757 76580 22160 30955 16974 18708 13380 18709 16973 18706 18607 74769 18707 12487 12519 12524 21416 68092 433702 16477 360013 16593 432508 67529 13047 19354 14534 19664 83490 18596 93687 77647 232232 18213 54214 70297 170787 18148 19211 16573 22059 108989 59079 56212 226861 20851 20850 18712 50490 14784 59069 19046 19248 70315 13866 107351 18519 15370 21803 667739 67300 17698 108147 20742 79221 15519 67384 17126 14183 17127 17128 67533 103806 333639 12223 71920 13874 15200 18412 17210 116849 21762 22123 12675 19179 19181 19182 23996 19184 26440 16653 19166 19167 26441 80903 384783 26442 22637 69077 14186 66997 14165 23997 14389 56436 16367 17463 14172 57296 80857 20422 26445 14170 26446 19172 14180 19173 14178 19175 14177 56458 67112 72345 19177 64654 21402 14175 14174 26443 14173 26444 14164 83379 19170 66413 26965 667035 22190 59029 13983 67089 70247 13982 208727 16399 14268 16154 58988 12478 264064 18591 17532 54601 56392 15185 15184 69162 51813 380928 17169 27267 15205 433759 16590 21787 15182 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA 319765 140486 140488 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375281 Hormone ligand-binding receptors 16867 22094 22095 170458 12640 14309 14715 14714 16866 14308 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669926 Nilotinib-resistant KIT mutants 16590 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 96%6814848 Glycerophospholipid catabolism 50767 56209 68616 320981 66569 241274 233552 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription 270118 15208 328572 19664 18129 333639 14128 103806 15205 14939 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%169893 Prolonged ERK activation events 327826 18211 109905 77480 54401 26395 26396 107746 109880 12929 12928 18049 26413 26417 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME%R-HSA-5619068.5 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) 170441 RHOC GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013106 RHOC GTPase cycle 26934 110279 11848 66146 74159 21873 71409 12389 22319 11855 277360 192662 19299 70361 71302 22325 229658 12261 29875 19877 17207 52666 94190 263803 14251 22379 218581 84004 20166 21917 19878 56491 13830 109904 16480 18708 68743 20874 213498 56419 12704 243362 110596 56389 207212 19285 14252 59079 73910 223666 234094 98386 330914 50768 232906 71435 16801 228359 404710 13367 75547 20868 320795 109333 72754 208846 69632 268739 11853 17925 22042 329366 109934 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function 12021 81601 327762 20422 233826 19361 114714 22427 19362 11920 12189 12190 237911 57434 19360 225182 26909 17535 21975 19363 19364 12144 27354 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation 16706 171463 67836 20779 109880 26413 26417 545987 12988 109905 17169 83409 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 11836 109689 216869 110135 99571 22330 MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206290 MPS IV - Morquio syndrome A 50917 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769743.1 Amplification and propagation of coagulation cascade 14067 19123 14723 11905 15160 109821 22371 14061 20720 268591 14069 19128 14058 14071 105722 14724 54368 14729 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 96%9605310 Defective Base Excision Repair Associated with MUTYH DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 13645 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 52717 99152 668450 229776 107995 217232 56317 59008 66156 56371 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family 22784 69048 230810 239436 22782 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation 233833 213988 236511 217351 19211 17454 214150 76850 239528 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 96%74749 Signal attenuation 16367 16334 14783 384783 16337 26413 26417 20662 20416 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 96%4549349 Defective ALG2 causes CDG-1i 56737 RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696270 RND2 GTPase cycle 13836 21927 214345 64652 232906 216197 11858 228359 67784 233877 381293 12389 83669 13510 11855 232339 208994 19249 75089 227937 67586 71228 93840 11671 327826 244418 229658 77480 105782 107971 16709 14269 218581 17063 269682 18708 19655 18709 53382 22042 18221 380664 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin 20850 20848 16367 16846 384783 19247 16452 12702 20851 ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-HSA-418990.6 Adherens junctions interactions 233833 16451 20665 12388 232440 19089 12387 13200 13626 12550 319149 20586 20779 13858 15077 104836 13345 12558 21417 52615 19646 26413 26417 21418 22325 13001 13000 100039026 17869 245688 18109 209462 22160 16480 16452 22330 66357 224619 66286 228839 18550 18553 69019 93759 226970 56529 13017 13016 20683 330662 56198 140580 77630 11492 239096 11797 12385 59058 110751 12564 15426 66624 16201 330914 20613 12552 57875 15227 11798 54721 99982 76687 228913 11727 217734 99011 11735 19645 12330 20901 60611 16601 114142 16600 53325 17246 16193 12555 93760 13430 12561 21762 22123 19179 21844 19181 19182 67956 23996 71740 19184 105837 18033 58235 26440 19294 19166 94332 19167 15220 26441 26442 69077 66997 23997 54725 56436 17463 215654 57296 320873 20422 12565 24136 26445 241201 26446 12563 19172 19173 12562 19175 15376 19697 19177 12560 12557 12554 26443 26444 16195 22431 19170 21423 14694 75339 66413 192173 667035 22190 239857 59029 230738 18746 16194 67089 76007 56805 70247 21406 21885 58998 18554 227485 227377 75234 15267 319168 319167 13040 13030 76850 239528 319186 319178 319183 319182 236511 319190 319176 319181 19353 20014 213988 103963 217351 214150 69038 13135 20583 14056 18717 17454 319169 57377 20848 625328 78303 319188 15270 433759 624153 15182 16430 14376 382522 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12532 100039786 50883 12534 12428 12427 54401 22628 22631 55948 22629 12649 22627 22390 PTK6 REGULATES CELL CYCLE%REACTOME%R-HSA-8849470.2 PTK6 Regulates Cell Cycle 20459 12447 12576 12567 12443 12566 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-HSA-3249367.2 STAT6-mediated induction of chemokines 72512 56480 20852 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking 193813 270160 12068 70785 317717 235633 56494 192232 60409 211922 89867 67443 225870 58194 235416 329260 216131 69440 20408 67231 19328 12402 66890 12663 56324 217449 15239 20404 20844 20405 13858 12874 56044 117197 245638 27059 18457 224139 94245 80912 11777 170760 54401 20615 21987 232946 20661 77929 67804 69178 12848 17920 109689 216869 100043806 26891 56444 67665 22428 13191 12121 76895 12344 238055 18476 59288 18475 105785 22365 64930 18002 14325 640703 22084 216705 14319 20980 22041 22318 22627 20979 11820 99412 22042 26934 11555 66397 69608 218811 320634 99683 20619 243764 77371 20334 56447 54161 66371 68953 75608 208092 12836 66700 59042 100017 76877 17918 56395 14366 76709 73178 22418 105513 11771 11772 11650 71770 56443 68137 66913 68089 67771 56378 66713 232910 74117 11773 16835 50797 70349 12847 13543 17913 54160 108148 66111 54399 75612 217615 104015 73470 16563 234663 77980 213827 11844 53334 68097 73804 14269 67511 56358 214459 14799 56455 26951 229841 75985 68938 228850 19325 68328 18472 57915 20528 210789 68365 74741 235661 18195 110379 13427 11839 19157 13426 13645 67474 19159 13424 19158 228421 72318 27277 73124 11998 12000 21872 240641 269152 16565 16564 16552 11891 16580 16581 67023 16561 16562 72772 16558 70218 20932 75050 16554 286942 71116 16578 319991 224630 16560 11774 26754 241113 69654 71648 17274 19353 53413 11843 20336 107371 16569 68449 108079 381605 67046 19079 54130 100855 14423 105504 19341 108097 56486 211446 108995 77407 19337 269589 102058 74105 224617 19082 260302 235442 233204 17158 56715 103724 23797 19338 209815 93739 28169 22241 54189 227800 69940 66687 207592 16570 19326 70296 107338 106039 22628 215114 11651 66482 11652 53357 338366 17886 109181 107305 72543 27681 70160 194309 52348 116733 73711 16568 22088 67123 330192 28084 76959 53869 66201 13649 20479 12500 21802 66914 55948 12502 12638 12504 53598 108099 104318 16594 668303 16579 232943 19348 216363 71819 16593 16551 110033 13047 209737 74764 76932 73296 108123 108124 16004 74375 76332 16834 14609 226089 14619 76688 270192 19345 53611 271457 56367 19344 319642 102339 19346 98910 58244 70646 78304 338337 104303 17957 67542 78689 242406 56382 53330 228960 69834 224705 76899 245944 97484 68505 233824 54214 12662 232286 68299 22319 227746 70297 19349 56418 70361 100039786 16572 66251 16573 16443 56389 66905 14615 14610 14617 20909 12343 12345 11842 12340 16571 319934 67300 13429 12757 20739 20740 74947 11733 11735 640524 20742 20741 20743 103967 80297 19339 11607 12223 71920 13874 20508 15200 21336 22320 26893 17113 14533 13423 11840 74325 26894 15481 67489 20955 11766 108679 11781 108011 215890 74438 105245 64138 13430 11782 26572 72685 26895 16334 74018 667035 22190 18783 110355 77038 11768 11769 108012 11764 11765 11767 252903 14618 20912 13132 13043 73094 229521 194590 210108 233489 80718 218503 30931 228998 18704 30934 14621 74015 225152 13854 353155 66691 17155 14613 67091 108800 17156 14612 20703 80708 230815 14611 66226 66616 14622 19324 240028 20616 14620 105522 20403 14616 243819 13855 14623 14067 231580 118454 69162 11845 75964 14275 67602 270096 12793 15463 217835 67857 18717 14569 100042773 29816 66975 20333 56017 14567 215474 218038 72433 207352 30948 227801 74498 13859 102442 22631 66682 320129 76954 52036 12492 106572 22629 76983 60510 19347 13032 269774 229541 245828 23969 72121 12794 20975 67790 240667 106628 72825 67727 14725 320714 214895 16197 216344 59005 55925 67844 14069 66147 74760 78232 23970 245886 56041 170625 320560 333883 54609 329727 21787 56085 320435 27096 226407 72978 105841 227648 19330 76308 74030 76510 329877 100042343 209773 50907 192236 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 96%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 13478 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 96%5654736 Signaling by FGFR1 14172 80857 14180 12402 14177 67112 24064 64654 17346 14175 14174 14173 14164 71436 109880 667035 22190 19247 26413 26417 327826 399558 116701 396184 114715 114716 18176 14388 20662 21814 15461 19052 67903 107971 19053 51792 18803 18708 14165 18706 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 328572 100039786 20683 54401 22628 22631 55948 22629 17127 12389 17128 22196 22627 67089 18607 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane 18704 234729 225326 54384 170749 17772 103199 77116 210376 75669 18711 RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013405 RHOD GTPase cycle 26934 214230 208263 70497 12389 18844 70598 22319 241656 11855 19349 68428 70361 71302 229658 13726 68917 23943 27360 75415 52331 218581 84004 21917 56491 66871 18708 18709 218756 56419 70804 380664 11736 56320 109711 223666 83397 69922 98386 434204 330914 232906 76763 71435 228359 13367 11854 27984 235611 12345 16906 ABACAVIR ADME%REACTOME DATABASE ID RELEASE 96%2161522 Abacavir ADME 20518 75894 20517 26357 20519 18671 76952 18534 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK 20111 17392 13649 110651 18176 20112 20662 15461 15200 14459 12426 23939 18750 26413 26417 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428559 Proton-coupled neutral amino acid transporters 246049 215335 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951911.2 RUNX3 regulates RUNX1-mediated transcription 12400 12399 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer 15200 11839 13649 21802 13645 12223 71920 13874 FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 96%9758920 Formation of lateral plate mesoderm 16147 14463 12159 15227 20423 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) 15586 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy 233870 77573 233405 67443 78610 269338 228545 22365 71732 218035 80743 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates 17001 14865 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling 16891 11806 11813 11307 11657 11814 11816 16816 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 17168 216805 101142 230676 270802 98402 268933 56032 72124 71962 216742 319481 101148 277854 252875 70394 56717 242341 68775 140742 66508 76252 545987 11972 108664 66290 54170 11964 52187 68576 110935 66096 11966 83409 100039636 74370 66335 68441 11973 11974 268706 74915 338375 245670 73834 114143 66237 230784 110379 27060 56716 66144 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%416700 Other semaphorin interactions 16412 83433 18845 67784 20349 140571 20356 18844 22177 20354 20358 109700 12517 243743 54712 20361 19264 214968 20351 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9915355 Beta-ketothiolase deficiency 110446 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%168256 Immune System 21943 53381 70450 12654 56208 13014 102595 170813 14190 12796 76905 20892 67912 53328 71728 76025 229574 12508 12514 78892 68724 26949 232413 27261 433375 235627 19074 19271 18126 19263 18103 72461 17523 70152 52633 217353 22436 19276 22325 69981 667301 231887 72042 69660 71869 72065 100042069 394252 78388 23917 21946 16970 57257 227960 67689 74287 19877 223978 100037283 11571 208795 380924 11465 14600 245126 19116 20568 216233 383295 12700 241197 22352 67213 18813 83768 69189 218978 18703 268379 15516 107767 100040018 13244 66892 93726 54159 56318 12609 55950 17395 70536 100040603 21930 20195 212114 53856 18600 11593 74039 73690 56016 545878 16783 80796 16172 54672 108888 18550 17064 56031 11605 66222 69550 96979 12283 13861 20972 71517 69537 381812 66508 14667 545987 16678 80860 13684 67862 66612 28185 20409 74012 208643 19288 76299 66060 14824 83409 18521 13690 22318 20614 20907 24088 21897 14469 257630 23845 66397 171095 69608 15006 218811 99683 68981 240095 667803 14991 77371 23806 55932 20334 21899 53379 98758 16176 12362 12363 22195 50873 17002 16396 236573 12370 230861 19766 11797 56532 16173 22030 16363 56424 67245 69146 11796 14827 50701 53378 16175 54722 434174 14082 13205 246728 16171 19260 15526 22210 269717 109305 12322 12323 108058 12325 19249 19250 20866 19253 104831 19259 229709 19256 16438 16182 16439 24058 16068 18747 320139 56294 19255 117149 12491 73914 18125 20193 16440 110651 20112 18383 26377 21935 620235 240873 24099 19695 22166 57916 22163 22164 245527 18489 12652 16429 77799 18843 326623 19194 78416 171211 228801 57757 242100 20491 72049 85030 50930 26399 11927 21944 20293 21934 26400 27279 80898 21940 26398 21941 26420 21949 26414 259301 26397 21948 228796 76113 17000 16994 11758 16992 75526 384997 23939 13608 13607 21942 16193 667310 15977 26419 18803 19294 12043 12048 13629 11487 11491 16195 18746 19225 11689 15139 14962 12263 12266 625018 12265 80876 74735 22329 19824 23960 225467 67781 65972 229900 232714 246727 56045 17318 56417 71884 231655 93679 66141 13665 224762 67204 286940 67525 58185 26905 70110 211948 15512 15482 54139 57444 52668 67513 67030 55992 667370 101700 112419 15958 76500 101831 24014 13653 15061 104806 94088 80890 360213 20617 56631 16391 226641 71885 22670 319236 14087 15894 214158 229644 100040608 237211 15900 72775 229898 66854 60534 71955 57437 108995 19089 53357 16153 17886 71481 211550 55948 67731 14751 22160 12772 12768 12458 13038 18386 13039 12702 14462 16854 16477 14293 12765 227288 16880 19156 57349 20303 20304 20292 20302 20297 100039973 20299 18148 19211 16184 16183 330122 14825 19246 23988 19258 14229 15945 57743 17534 21354 21356 21355 93836 53421 20909 100043039 246278 66212 12343 12345 57264 12340 21858 21857 11783 69562 18854 66105 80751 11350 17127 66313 58992 16621 17131 19885 22608 268973 75788 16653 12981 12978 56458 16179 18390 16408 14127 16181 16878 14128 21937 21938 16178 12366 16160 16401 16159 16155 16154 21926 12985 56338 56508 223864 12053 20716 12359 227290 117586 15978 12843 18613 20911 12512 83814 104009 11625 20527 74145 12631 14088 94175 22339 18407 71393 20586 21936 433766 107568 29875 110157 13169 14161 215449 16452 110135 99571 22330 16993 13191 242341 68775 15369 76252 11972 108664 66290 14325 11964 110935 11966 100039636 66335 11973 11974 74915 14319 338375 21871 73834 114143 66237 11975 27060 16819 77674 140494 654464 266620 654459 75400 66144 246700 71902 246082 654460 654465 244332 56480 629114 446099 54131 207521 58203 16885 74256 21929 67963 18453 11771 11772 71770 232345 218203 381925 18807 71910 50931 50926 66162 18569 12798 18738 232910 50498 11773 12931 11632 20849 209590 18826 17319 18788 16162 16161 18749 246779 16188 16185 15926 12984 12982 16192 16191 109754 11676 14387 14595 75612 110078 110095 20969 18436 15442 50917 16189 16163 16174 93871 12505 19373 19374 53603 16196 57914 212032 77559 66681 231507 19325 68365 21351 100038891 18641 16170 20908 76527 109658 19152 19283 242700 76507 18648 17159 110173 225913 27357 15898 16409 16421 72157 16423 16411 16414 78369 232449 11674 12475 22031 56489 225471 106759 21353 71648 14256 18950 11717 17390 11821 17161 13666 19043 56468 54607 76501 12238 16198 16199 74125 83490 77647 21682 16923 11848 19698 15896 73086 170786 22319 13010 51788 19349 18805 22139 52588 11870 22072 544963 16572 16573 16412 140579 17380 16790 94176 330662 70495 52331 20430 17079 16803 329547 17084 56212 13350 16592 12306 16410 14083 11352 71745 17925 14026 17973 20663 12331 22323 331461 19025 18010 216197 16190 69677 100042555 13712 16156 83995 17984 18412 107527 16165 16164 14086 26406 22320 19229 56708 77125 50905 11840 18413 329244 15481 17210 237310 20955 213208 237313 54450 60505 338374 93672 105245 58181 64138 60504 13430 116849 215274 69581 16169 16168 140806 17082 18414 53314 54473 218624 14873 215257 234836 13019 230828 57890 12804 12803 54448 384783 75669 81897 14389 16367 225326 14173 216445 16194 70719 12986 117589 78541 69299 218215 94090 233902 69116 208650 73998 50760 20821 235320 242521 209239 74492 75234 66799 72194 67845 15204 69706 235439 57751 140630 94091 217194 16924 22019 226541 65257 104184 23912 19820 78913 242785 56791 68729 69010 211949 66743 233040 76763 231672 18744 50492 224826 231863 101358 12449 224023 109161 22193 71538 76375 67455 14794 217217 71999 76577 269529 83962 230654 635668 240028 66515 269514 78889 68431 230904 28105 71865 14569 380928 50868 207215 22200 627648 207304 75717 106572 70294 67921 100041484 22192 66663 142688 243574 321006 268291 209200 74646 448987 22346 56736 228003 12703 19330 212919 54484 20439 218793 20437 636931 328234 76608 19823 227738 74153 22201 79263 22209 74244 53323 140629 68497 70620 330369 23807 140499 59009 17237 50788 22213 67128 22222 224938 22214 17999 98766 67615 19155 268470 67588 59026 230903 66772 208372 76454 70093 329152 117146 65247 22215 65255 67345 81018 84585 217342 142687 209462 78910 231380 65256 70392 69807 244421 22036 224170 240396 225055 17025 24105 232539 56515 170823 215061 67138 19822 74132 67490 231670 672511 56444 226098 67665 69754 22428 224619 77113 14897 12344 59044 207952 59288 70348 18475 320118 170737 70928 56228 30843 68854 76294 211007 72323 399566 30945 68098 100763 214931 19264 83433 108015 15234 22177 50884 83767 110351 329165 26934 105855 242687 17969 11308 20619 13058 13057 108100 17970 101314 17972 12261 56485 19164 59287 15162 12526 140580 234779 17918 12267 76709 73178 20963 12229 56443 19200 80987 68089 67771 11867 54483 56378 66713 74117 245880 14191 22376 215280 18439 68524 67955 13035 17882 14129 17913 246256 14131 17909 66824 330319 216799 76884 14302 16186 16331 16332 104759 74096 192656 17874 17258 20203 20210 24110 257632 26940 266632 26401 80750 223664 53791 107607 69721 231130 93834 270151 11596 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 69654 104112 16569 54130 16570 66848 66557 16568 53598 210710 22154 380711 20469 18127 16594 668303 16579 232943 13036 13034 19348 229445 67065 56464 71819 74414 226977 16593 16551 110033 78929 280408 16149 209737 74764 26939 15002 67486 15001 70408 64291 20018 16768 69870 15000 70428 14998 218832 67005 20016 12909 16004 319642 19346 66369 80910 192176 20851 20850 18712 14784 13033 18986 16571 18016 13429 17698 20740 74947 20743 103967 17967 269116 72269 19339 13002 21762 22123 12675 52440 108723 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 18037 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 13682 19177 13681 21402 16150 26443 26444 16151 19170 19696 12042 66413 26965 667035 22190 18751 240354 59029 26409 67089 103583 70247 56469 19883 18753 22196 170743 13040 19141 170744 13030 17535 22027 54445 142980 667277 239447 317677 14134 17195 12944 11537 16904 12259 71693 12260 12262 14783 19090 384309 22040 383619 72162 72935 72512 54123 68891 20852 268857 22596 13211 14375 214763 20703 69162 56619 332579 20333 26888 56644 381809 17312 56620 17474 13032 245828 217232 56317 59008 66156 216080 69957 333883 17222 68612 52563 22194 68999 52206 100039535 99152 668450 12534 12387 58194 12550 12402 20779 20404 107746 12929 26416 12928 56044 18754 26413 26417 29857 20416 109905 19094 102626 54401 26415 26395 18176 20662 15461 17164 11846 13830 16480 13505 328572 15129 17087 15368 19041 238055 13367 20868 30960 17260 21898 18024 12914 11909 640703 268373 19055 19056 19419 18018 18019 240168 19058 14225 18021 20656 26458 56484 16476 113868 16906 668218 11820 12125 14103 12333 68682 56438 67526 11793 54644 12182 16201 58222 26364 16453 16177 54721 13609 20847 15980 17060 15979 12518 15985 15975 110606 26554 14272 211255 19342 19336 70349 110006 15212 12091 11881 12575 12567 18793 12443 56371 27401 227753 12576 14255 73470 16563 234663 19386 140792 109154 73699 11799 12371 19340 68097 19052 73804 19053 51792 66934 445007 226849 225849 26931 21770 66902 26932 56455 71665 229841 107995 24015 69912 70568 103468 235661 234865 59015 69736 216238 71398 27056 78287 110379 266692 69928 13427 14828 19128 13426 217303 67474 13424 228421 17533 19109 11687 13510 16364 15439 12367 18772 109620 11891 66420 69833 245841 20932 17749 11977 100043714 21679 15267 21676 319168 21678 319167 14281 224105 50770 226144 105722 547431 75778 238555 76850 237754 239528 195349 319186 12231 21677 11980 319178 319183 319182 193670 54197 236511 319190 26754 241113 14282 56717 70377 319176 76295 18034 216440 319181 19353 20014 213988 57261 103963 217351 56637 214150 69038 227743 13135 19247 13819 14969 14968 66753 104709 67819 208154 14056 15170 116891 17454 20338 235606 319169 223646 109270 50723 67075 105787 67512 108079 20846 19079 20848 108097 625328 78303 319188 210992 15270 58205 16818 19082 80286 56716 624153 68292 216134 23797 16430 382522 233833 53859 16451 21415 232440 18806 13200 13626 319149 72297 22628 320207 16478 16842 22612 11651 11652 12483 22324 15077 269523 66310 18710 140858 97064 20719 18566 11886 230979 21417 18792 52615 26410 19646 213464 14360 12988 11910 22165 214162 13001 13000 100039026 17869 245688 20747 12500 22601 12501 12502 15251 17096 23808 12504 18109 244373 18005 16784 17444 78757 228775 60533 17750 76580 108099 16362 30955 12774 18708 18709 18479 12477 18706 18607 74769 18707 66357 12487 12519 12524 21414 21416 231051 17394 18481 19354 20201 20202 240047 11501 67923 71586 230073 66641 71956 228607 217069 19345 21454 19344 19261 106052 108078 242960 12346 20343 30838 13052 12469 270152 12461 58217 30050 50762 227613 50754 11461 668101 232801 30925 217304 26904 14130 217306 100043861 213980 16641 16643 232790 68628 16498 71326 50928 52685 22059 75345 21947 57781 17086 50789 231805 170741 84544 30839 243958 243864 54215 75863 629970 20698 100038830 52855 170762 328833 108989 83382 231042 246746 227699 20612 223921 319352 227720 27007 269113 54698 66679 18146 18141 12480 20400 107939 12525 69482 225825 71805 224840 17470 140497 23900 54563 16646 19069 70699 72787 94212 18226 218210 16419 16952 19248 55991 269328 17829 21803 18636 100039649 140474 224116 67300 12757 17063 73732 353328 12317 100038882 56615 193740 12330 15519 16211 100039592 16648 19106 100037258 19204 68197 381686 16649 14289 667618 20813 12143 17392 72621 14061 22361 100561 385643 107829 192170 16822 22637 16797 630146 23880 16428 56743 227394 20674 23992 21357 22063 18173 28240 11883 14126 14125 16776 14268 69583 22370 230558 15007 319430 12010 12258 195046 11768 110382 11769 12478 108012 12520 11764 69379 12279 11765 50702 11767 12628 252903 71756 12759 12630 93721 12273 16912 12274 19171 545366 17221 56373 12902 109828 16913 19186 19188 100041766 216150 66513 93765 66589 18761 22034 19395 66724 233046 68652 52120 20111 22631 16197 18976 80861 108086 12977 224794 67706 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription 18027 18029 20823 18032 21374 67065 71752 74414 233863 66420 72308 69833 66596 227644 78929 245841 66653 544971 77634 70239 20841 18986 269252 102209 26939 330959 67486 75627 70408 20018 69870 70428 67371 17749 218832 100043714 67005 20016 98488 12909 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 96%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 12914 12400 18751 12981 16854 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system 21943 12534 56208 19823 74153 12402 20892 20586 20779 107746 21936 12929 26416 12928 19271 56044 18126 17999 26413 26417 20416 19094 102626 26395 18176 20662 15461 17164 110157 11465 14600 19116 215449 216233 12700 22352 16452 66892 15368 12609 17395 16172 18550 17260 69550 13684 11909 208643 268373 15234 20656 56484 13690 16476 16906 22318 20614 20907 16819 11820 12125 14469 14103 257630 56480 54131 171095 56438 15006 68981 240095 667803 14991 23806 55932 53379 98758 16176 12362 15162 236573 12370 230861 11797 16173 22030 16201 16363 67245 69146 234779 11796 18453 16453 16177 54721 16175 20963 13609 434174 20847 15980 17060 15979 15975 246728 50931 50926 110606 16171 66162 18569 12798 14272 18738 50498 12931 11632 20849 209590 18826 17319 18788 16162 16161 246779 15526 16188 16185 12984 12982 16192 16191 13035 14129 12575 12443 12322 12323 108058 12325 19249 16186 19250 19253 12576 104831 14255 19259 16331 19256 16332 16182 24058 16068 18747 320139 56294 19255 12491 73914 19386 20969 73699 11799 110651 20112 18383 16189 21935 16163 19052 16174 240873 24099 19053 51792 57916 22163 93871 22164 19373 245527 12505 19374 53603 16196 57914 77799 445007 326623 226849 171211 21770 66902 20491 72049 85030 50930 21944 26399 21934 20293 27279 26400 21940 21941 26398 21949 26420 26414 21948 26397 17000 16994 16992 13608 23939 24015 13607 21942 69912 16193 667310 103468 15977 26419 234865 59015 69736 27056 21351 110379 69928 18803 100038891 14828 12043 12048 16170 20908 76527 19109 109658 19152 19283 242700 11687 11491 16364 16195 12367 192656 17874 17258 20203 20210 19225 24110 11689 257632 266632 80750 223664 107607 69721 231130 12265 93834 80876 270151 74735 16409 11596 22329 67454 19824 240518 23960 71966 225467 108960 67781 59025 65972 16411 100040260 229900 16414 101568 246727 235584 56045 67603 17318 319520 56417 72349 231655 93679 66141 224762 14281 13665 286940 224105 67204 67525 58185 70110 26905 211948 15512 15482 54139 57444 52668 67513 67030 55992 667370 101700 112419 22031 15958 76500 101831 24014 13653 18034 15061 104806 94088 80890 360213 20617 56631 16391 226641 14256 71885 22670 319236 14087 15894 19247 214158 229644 14969 100040608 14968 237211 15900 72775 229898 66854 60534 15170 17390 20846 20848 16818 23797 53859 16451 17161 319149 13666 19043 22612 11651 11652 22324 15077 18710 16153 71481 211550 21417 56468 230979 26410 14360 54607 12988 17869 55948 15251 17096 12504 17444 17750 22160 12772 16362 12774 12768 18708 18709 18706 74769 18707 210710 12519 18386 12524 12702 14462 16198 16199 16477 14293 16880 67923 71586 230073 228607 217069 21454 12346 21682 16923 20303 20304 19698 20292 73086 20302 20297 100039973 20299 18148 11461 16184 16183 330122 16412 66369 22059 21947 14825 19246 20698 170762 108989 231042 227699 192176 223921 227720 269113 16803 66679 18141 107939 23988 69482 71805 19258 54563 16646 19069 70699 72787 20851 18226 20850 218210 18712 14784 14229 16952 15945 19248 20909 18986 12340 21857 12306 17829 21803 11352 17698 17973 18854 100038882 20663 66105 193740 12330 17967 331461 15519 16211 100039592 16648 19106 100037258 17127 19204 381686 16649 17131 667618 17392 16190 69677 100042555 13712 16156 83995 17984 18412 107527 16165 16164 14086 26406 19229 56708 19885 77125 50905 11840 18413 329244 15481 17210 237310 20955 22608 213208 237313 54450 60505 338374 93672 58181 60504 116849 215274 69581 21762 16169 22123 16168 12675 140806 17082 19179 18414 19181 53314 19182 54473 23996 218624 19184 14873 215257 18033 234836 26440 16653 13019 19166 230828 18035 107829 57890 19167 12804 18036 12981 12803 26441 192170 12978 54448 384783 26442 69077 66997 23997 12234 14389 56436 16367 17463 57296 20422 26445 26446 19172 19173 19175 56458 19697 13682 19177 20674 13681 21402 16150 23992 26443 14173 26444 21357 16151 19170 66413 26965 16179 667035 22190 18390 59029 26409 16194 67089 103583 70247 12986 56469 19883 18753 16181 16776 20821 16878 14128 21937 21938 22196 16178 14268 16160 16159 16155 16154 69583 21926 12985 15007 12010 22027 12053 15978 12843 56791 20911 14783 16913 54123 20852 19188 100041766 13211 66513 93765 66589 22034 66724 74145 68652 12631 20111 14088 22200 22631 75717 22192 16197 18976 216080 22339 12977 12703 22194 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%180336 SHC1 events in EGFR signaling 15461 15200 11839 13649 21802 13645 12223 18176 71920 20662 13874 20416 PHOSPHOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%1483257 Phospholipid metabolism 114874 28169 68262 66659 18806 55979 225010 18778 14792 329502 320207 66857 271844 67452 237625 665270 66853 270084 53357 67216 68255 232889 18710 225845 13001 13000 100039026 30955 18708 18709 18706 108083 74769 18707 66826 271457 100434 213603 242259 70129 68682 64436 320634 14732 19211 18805 23945 18718 64899 215456 14245 234729 54384 17772 320981 64898 216724 13350 18807 210376 66569 241274 99138 240752 18705 234129 67800 50767 14571 18720 68616 18719 97287 233315 11842 106869 107650 103199 244882 18711 12169 233552 268783 69769 74302 53332 219135 84095 319934 240753 101490 231999 109135 19062 269180 66443 234515 83435 83436 101476 56209 170749 19249 104015 16331 16332 83493 77980 67073 104759 224020 77116 97212 231086 12038 12647 11423 219024 99712 236899 12651 237928 79196 56018 11840 237542 212862 28042 12660 70568 13026 85031 76574 74182 106861 105501 18559 27281 18618 102278 68365 67078 71760 74451 12891 75320 66461 68671 218121 226856 245532 320951 66586 668257 192654 74486 56305 116939 66727 266692 110911 75669 225326 19210 27388 76768 18783 69923 18739 18704 74596 19679 327958 52858 104709 18717 77582 67512 14712 18779 239759 20975 26971 333433 19341 108958 99010 210992 14555 26970 26565 215708 102247 18784 18782 78390 66350 231510 52123 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion 14069 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 96%3781860 Diseases associated with N-glycosylation of proteins 102580 24070 208211 381903 227619 13478 328370 18010 19025 14595 57377 217664 207958 56737 320438 12091 66789 208624 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 71279 13340 269346 56327 11739 63959 434203 433923 11740 114304 107566 243328 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-HSA-375165.5 NCAM signaling for neurite out-growth 13004 640524 20742 20741 73086 20743 17967 26413 26417 14360 80297 12830 11603 12829 12828 12827 12826 18176 20662 12841 15461 12840 245026 12839 12835 20450 12834 58226 12288 12833 12291 239556 14573 20452 12295 12296 12297 12298 14586 19122 14585 19197 14588 19262 12292 12289 21367 14083 18188 20739 20740 11876 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME%R-HSA-5619046.4 Defective SLC26A4 causes Pendred syndrome (PDS) 23985 RHOQ GTPASE CYCLE%REACTOME%R-HSA-9013406.5 RHOQ GTPase cycle 233071 216963 66894 70497 12389 68146 22319 20619 11855 277360 260409 263406 19349 26431 70584 68428 328232 71302 229658 104252 16443 75739 12638 29875 217866 105782 94190 14269 218581 56699 66871 13830 224105 226751 16480 218756 18479 56419 104445 14270 330914 50768 232906 94221 71435 228359 404710 73178 20514 66508 54126 106628 14609 71709 22042 236915 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome 12362 66824 383619 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 96%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 68953 105513 75608 56208 67443 225326 78610 208092 75669 66371 66700 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 96%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 12367 670717 11783 66593 12371 11798 12369 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins 66341 67241 66647 67872 18854 68501 226026 11545 240087 70238 56233 56469 19365 19386 59004 20610 20842 12418 22196 108138 100043429 15204 170762 24061 108989 231042 227699 223921 227720 445007 269113 19357 12151 66679 22658 18141 107939 19763 69482 71805 54383 54563 13619 19069 22427 70699 241915 72787 12416 18226 218210 12189 26370 19821 69912 12144 12578 13006 68275 103468 22591 234865 30951 59015 69736 110379 20843 67711 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME DATABASE ID RELEASE 96%9827857 Specification of primordial germ cells 18999 12159 100038891 13813 12767 20671 12142 14726 21420 214133 244551 12396 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%74752 Signaling by Insulin receptor 14389 16367 14172 80857 18576 16334 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14255 26413 26417 20416 327826 15925 18176 20662 15461 19268 228775 19246 18708 75778 18709 18706 18607 74769 14783 16337 14256 242341 68775 13033 19247 76252 11972 108664 66290 11964 110935 11966 100039636 66335 11973 11974 74915 14388 338375 21871 73834 114143 66237 11975 54411 27060 80903 384783 140494 75669 14186 14165 81897 66144 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702614 ponatinib-resistant FLT3 mutants 14255 METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids 20602 23989 12389 66853 16922 18631 12908 17117 68801 67528 21835 74114 14311 12640 110959 13075 14081 228061 56185 80911 28077 13850 12012 111175 20186 13123 171285 93732 104086 20280 13122 77337 67689 208665 171210 101502 83702 17164 56794 67224 19014 229003 11655 11865 66999 13244 328572 16993 15446 13106 21372 109151 11624 11806 11622 72303 17977 107141 73690 19017 13077 18143 56448 13076 30960 13114 17978 59035 66826 81004 13110 66993 11605 96979 24001 12753 27413 15183 14667 20185 217166 66612 12914 56406 26357 108098 18670 74147 28253 171282 11666 26458 15488 113868 170789 26378 66172 192191 78334 73166 231070 270669 110196 100434 14137 213603 100040592 242259 20683 66397 70129 18044 68682 18045 20933 18046 235293 68603 69608 218811 14732 320634 99683 20775 20249 235623 67131 192156 15484 170439 15483 72999 12401 13121 20788 13360 107476 100705 14593 381379 16987 71949 17764 75292 56453 101540 77371 67630 319554 230379 17855 239559 20334 67219 53897 76893 66190 432628 74442 66183 171168 338521 20773 77626 26879 22234 14421 545975 14420 241447 104725 66844 56632 19012 50784 22239 18760 74411 238011 74754 230101 66234 433323 18194 70059 110460 76199 208449 68865 54447 13595 67260 15490 67916 100017 17001 227102 268656 228677 93898 242083 223753 57875 81535 70750 20397 76303 22259 71720 228983 12642 65969 15486 11303 66065 114664 14187 66113 99031 71240 105349 100273 20520 11657 18807 11807 11684 20859 18749 15485 14598 319446 70893 15212 15211 23887 12091 11677 11881 13479 244757 108105 50935 19249 104015 16331 16332 18747 19047 12491 83493 77980 67073 104759 224020 77116 76408 14775 56336 70316 56386 17436 20524 13070 79196 237542 28042 70568 85031 107765 74182 12896 105501 12895 27281 68041 102278 19224 68365 67078 66198 71760 264895 74451 77219 12891 14200 75320 12408 66461 14073 68671 66834 218121 18979 226856 67420 245532 320951 57279 66586 330260 668257 269823 192654 70025 74486 243168 56305 116939 71985 66727 52538 266692 72482 110911 11688 78245 69573 54218 64292 102632 68680 14373 66469 228859 56360 330450 94185 171281 67103 74156 320997 245533 13120 13167 11690 223722 631304 329910 11687 195733 13118 72054 17250 19210 208285 27388 21391 19223 13124 100042622 76205 59045 12257 170459 20845 19225 11689 110821 66904 76768 17850 73724 14344 109136 14343 68165 14149 14148 12894 18181 67544 75778 230753 69923 13081 19063 257633 433256 13072 83603 15492 74522 15497 54397 13079 50790 15487 328845 74205 57874 14979 30963 104112 106529 54325 66775 12683 94180 12686 216739 74559 234309 243078 70757 56348 104709 99035 26568 54326 77582 67512 14712 108079 18779 239759 26971 333433 19341 108097 108958 99010 210992 14555 26970 26565 20444 215708 102247 18784 18782 78390 66350 231510 52123 114874 28169 68262 66659 18806 55979 225010 18778 14792 329502 320207 66857 271844 67452 237625 665270 270084 53357 67216 68255 232889 18710 225845 11886 70625 68975 244209 234959 94112 13001 13000 70208 100039026 103236 11520 56771 50493 228775 80509 108099 30955 18708 18709 18706 108083 74769 18707 98386 14776 56310 26896 28250 11409 93747 15107 64291 20216 56473 76267 19156 271457 14466 64436 19211 18805 20698 56491 67279 23945 75497 16890 18718 20494 19045 20493 64899 16866 106407 21884 330962 14626 26459 14933 170460 67469 215456 71519 14245 106648 19046 100040843 234729 103968 13078 11370 54384 66905 17772 64898 320981 13350 216724 12140 210376 16204 66569 16592 11864 241274 99138 14077 17979 240752 233549 18705 67800 234129 14571 50767 68393 18720 14079 68616 14080 18719 75772 97287 11770 233315 11842 106869 107650 103199 244882 100043508 18711 12169 233552 268783 69769 74302 53332 219135 84095 319934 240753 101490 231999 109135 19062 269180 66443 234515 83435 83436 101476 56209 170749 59024 327987 225742 26938 16211 20182 19025 57357 97212 50877 11363 231086 12038 12647 11423 19384 20454 54486 14865 11606 11686 23801 13116 625249 13115 14104 110115 18010 394434 56050 23956 219024 19215 69790 99712 17113 236899 12651 237928 11840 56018 212862 12660 13026 76574 106861 18559 18618 66427 20598 67041 58994 64059 69772 208982 110446 15360 78894 71911 15356 170826 75669 26457 225326 74159 58911 271970 67902 75613 22260 545260 20181 22337 19013 11883 19883 18783 59004 74008 77041 26379 19016 22196 100043429 20787 216820 19141 264064 19731 14473 94224 13074 78925 20597 18739 18704 74596 19679 327958 52858 74121 11364 11863 67460 13177 216154 18717 51813 69792 26922 20975 20466 14725 18976 67381 19015 SIGNALING BY RAS GTPASE MUTANTS%REACTOME%R-HSA-9753512.2 Signaling by RAS GTPase mutants 15461 16653 18176 SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions 100434 213603 11998 227394 242259 75750 70129 68682 63993 101488 114644 216225 27376 235504 18399 13358 19879 20521 20502 28250 57274 58807 80879 20501 20503 13723 12215 20500 28253 24059 241612 108115 237831 67863 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 96%5579028 Defective CYP17A1 causes AH5 13074 MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 96%1222449 Mtb iron assimilation by chelation 17002 DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o 13481 68563 13480 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes 15161 228829 108155 231051 67278 74322 17283 217031 226976 101739 208146 76719 66310 75812 140858 69556 69612 233904 101206 208043 13486 213464 217588 54194 108946 67933 214162 665775 75565 228714 56406 67773 239510 77305 14534 75410 22289 55982 18519 23808 381022 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%74259 Purine catabolism 230718 214254 50773 18950 14544 53893 66358 75686 76952 23959 381101 22436 16434 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME%R-HSA-210746.3 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 53626 11925 18088 18012 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 96%168176 Toll Like Receptor 5 (TLR5) Cascade 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 71481 667035 26416 211550 22190 17258 20203 26410 26409 20210 24110 26413 103583 257632 26417 26940 266632 26401 80750 223664 53791 107607 19094 69721 102626 231130 93834 270151 73699 11596 26395 67454 22059 240518 71966 110651 108960 20112 59025 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 12370 21770 22030 67245 26399 26400 18034 26398 26420 13712 26414 26397 17260 434174 66513 93765 66589 23939 22034 66724 68652 20111 11909 26419 12675 16476 18033 18035 18036 11820 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME%R-HSA-4549380.4 Defective ALG1 causes CDG-1k 208211 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME%R-HSA-9854311.2 Maturation of TCA enzymes and regulation of TCA cycle 68002 11429 269951 66945 110446 14297 66072 71238 68332 66052 67680 380840 64384 66925 74316 12974 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 96%9918487 Dengue Virus Genome Translation and Replication 67443 12282 13200 233726 13682 12317 13681 269523 235623 193740 667035 12330 22190 16211 100039592 16648 100037258 171210 13480 22196 217365 13481 20168 381686 16649 22352 18107 81910 230861 66892 213539 22230 66357 24127 68563 66624 14104 56445 11806 16646 66286 14827 18453 56298 103573 223697 18452 20014 66861 103963 218490 69038 13135 76687 69019 15481 18451 13684 22608 208643 56529 67075 110611 13690 14828 320452 67838 80286 192170 68292 19092 16430 18458 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs 12021 328572 216799 319176 320713 20844 12189 667035 22190 59029 68251 20184 70527 70681 76630 109359 107976 210766 319169 18519 621893 319162 15267 319173 319163 319168 319167 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development 233833 21943 17342 20665 21415 20682 18992 12387 15901 12575 209446 12550 17202 67155 107508 22628 20586 17201 21425 20588 16842 20587 17295 12443 12566 11652 12047 21385 69675 19303 12558 13612 26416 16881 11886 21417 232313 21752 329581 26413 18787 26417 21418 54401 328572 21414 21416 17216 239985 17218 13367 19017 56456 103573 66993 11972 93759 108664 66290 12578 12914 11964 93760 11966 100039636 66335 11973 11974 114143 12043 13190 22627 22173 22178 12531 20674 192119 245049 70127 16364 29861 269397 20431 19708 268996 16398 11891 171531 12055 12054 11461 77836 77045 83671 17364 18241 22196 68094 83796 83797 57376 76850 239528 236511 17918 22416 12189 213988 217351 56637 214150 21426 20583 20111 107045 226414 17454 97541 17169 216443 18505 22278 22631 13616 66355 22629 105148 15254 20466 231872 13614 66143 22771 18976 18817 17199 433759 13618 16590 15221 12977 104458 11694 68292 21386 23797 85305 17203 13722 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis 66812 74450 71743 75735 68087 211347 106564 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex 12234 93687 56436 17463 57296 21415 20422 26445 12387 26446 360216 19172 19173 19175 72345 19177 21402 56438 16842 26443 26444 19170 66413 26965 667035 22190 12005 59029 67089 70247 21885 21886 14296 73699 21888 212398 19052 19053 51792 226849 225849 26931 21770 26932 21414 21416 56637 21887 14797 21762 22123 19179 19181 19182 23996 19184 26440 433759 13017 19166 13016 19167 26441 26442 11789 69077 66997 23997 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 96%8934903 Receptor Mediated Mitophagy 66734 22241 13001 72018 13000 100039026 67443 67526 11793 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events 14702 14696 56470 104110 14697 14678 14677 240816 14687 18751 14679 18754 14710 432530 18755 14699 210044 66066 18761 104111 19734 14700 14688 14708 14706 14704 14695 224129 18753 11512 14693 11513 58175 11514 64337 11515 14709 18752 14701 11551 11552 11553 18750 56533 19736 242851 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 96%4793950 Defective MAN1B1 causes MRT15 227619 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139910 Activation of BMF and translocation to mitochondria 68097 26419 171543 SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo 22601 16798 54401 68473 75723 50523 232157 260305 21873 211652 56332 64010 56274 21872 13543 58231 12367 97064 22627 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity 19255 58194 20408 12402 56324 84092 15239 16206 20404 17295 15234 20844 20405 13858 667035 19246 22190 19271 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655332 Signaling by FGFR3 in disease 327826 14172 80857 14184 14180 64654 14175 18176 14388 20662 14173 14164 15461 18803 80903 18708 18706 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 96%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 100043429 56459 50995 20610 22196 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) 100042811 18293 78920 14194 56451 68015 20916 20917 14297 71238 68332 13382 380840 18115 15929 68002 170718 11429 67834 269951 66945 110446 66072 66052 67680 64384 66925 74316 12974 17448 SIGNALING BY LTK%REACTOME%R-HSA-9842663.1 Signaling by LTK 74769 16367 17005 51789 14784 18708 18709 18706 20662 620393 ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins 22072 12504 11870 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation 71398 16151 27056 100561 12675 16150 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin 74769 18707 13857 234779 320207 17096 18176 14388 20662 20851 22324 20850 15461 13856 107746 12929 18803 30955 18708 384783 16452 18706 20416 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 96%9909396 Circadian clock 20893 21425 66277 272322 12457 79362 18787 214162 13001 13000 100039026 19047 19014 229003 11865 19377 328572 21372 104318 109151 17977 19017 18143 17978 59035 81004 66993 17260 17261 12753 268903 19885 70461 15183 18626 20185 18627 225998 93759 18628 217166 12953 74343 12952 12914 382056 56406 11909 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 12568 26442 69077 66997 23997 27373 12234 56436 17463 57296 20422 26445 11998 26446 19172 19173 19175 14068 19177 21402 56438 26443 26444 19170 19653 66413 13170 26965 217732 667035 17691 22190 59029 67089 103583 70247 20181 19013 19883 50789 20787 12894 59027 19045 19046 216080 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation 26401 22030 69721 11596 71586 19697 230073 71966 12675 71956 16150 18034 228607 217069 16151 18033 434174 18035 18036 20203 11820 20210 22034 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 96%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 18508 66624 233081 66286 56529 18548 14607 14463 16392 236781 76687 13482 69019 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME DATABASE ID RELEASE 96%5619055 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) 238384 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) 640703 56043 77559 72157 68961 18679 110094 102093 110078 27357 18682 110095 14387 19309 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins 104158 11606 13809 17228 64138 14943 56373 70008 17380 16790 76703 12873 70495 11421 100038824 13035 13033 REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation 233833 213988 236511 217351 17454 214150 225872 76850 239528 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 96%442755 Activation of NMDA receptors and postsynaptic events 12326 14811 18039 216963 14810 11472 20779 320472 19087 19084 23859 14814 68606 52163 14813 12322 12323 108058 12325 26413 26417 18747 100039592 13385 53310 13383 110651 18176 20112 15461 108099 18607 53623 14799 241113 19088 16559 14802 55984 19108 19417 19418 19353 211323 22343 432530 14800 20111 640703 105787 11514 108079 14812 108030 64011 19079 18749 207565 108097 12361 19082 319924 67071 170483 22342 19085 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development 12842 12400 56275 225207 19645 20779 22612 15185 97064 68527 15183 26413 26417 11350 15213 16147 15214 11835 22601 212712 17125 14634 208727 15205 17128 14633 17130 17132 170574 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-HSA-8964539.5 Glutamate and glutamine metabolism 108653 14660 18242 66194 69051 209027 70266 14719 14661 14645 194237 216456 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 96%70171 Glycolysis 18639 18640 170768 18648 56012 15277 70974 15275 56421 18663 67980 18747 14447 19386 231103 73699 216019 14751 19052 19053 51792 170762 108989 231042 227699 100043349 223921 227720 445007 269113 11674 66679 72141 18141 230163 107939 212032 69482 21770 71805 226265 54563 19069 70699 72787 13806 18226 218210 21991 69912 13808 18655 103988 13807 103468 234865 59015 18749 69736 110379 270198 18641 11676 18642 26384 12183 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation 13001 16211 13000 100039026 66624 19047 66286 56529 19045 103573 18550 19046 76687 69019 15516 15481 15519 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME%R-HSA-9854907.3 Regulation of MITF-M dependent genes involved in metabolism 19017 93759 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 96%418890 Role of second messengers in netrin-1 signaling 22063 18738 22065 22067 18803 22066 26946 22068 13176 18208 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 72544 50911 24127 69639 72662 66446 227715 70640 75901 54401 17164 238799 22695 66362 109075 66583 27998 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 96%983231 Factors involved in megakaryocyte development and platelet production 74947 16570 319149 19087 19084 12566 15077 73470 12419 16563 16568 18747 11350 11640 217837 73804 16362 76088 16452 15129 16594 14462 229841 668303 22762 16579 232943 14461 17135 14460 19348 17134 14463 71819 16593 16551 22365 110033 209737 74764 15977 208869 78287 271457 210293 17863 12568 63955 22390 228421 26934 75974 16923 23921 240641 269152 16565 319899 16564 16552 16580 16581 13660 68813 16561 68732 16562 108829 20399 16558 56697 70218 15135 252966 75050 17133 16554 15132 286942 56248 259300 16578 57440 319991 16572 171580 16573 14464 16560 22059 94176 330662 238130 18022 19363 16363 114714 19088 14465 19353 99982 217864 12343 12345 15353 16569 12340 16571 20466 18749 625328 433759 67414 22761 170731 15182 67299 19085 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis 216151 15161 12326 381760 20181 19013 26379 18181 14390 19014 68346 229003 11655 14661 226169 670717 15278 21780 21372 109151 17977 19017 60525 17978 59035 81004 66993 17260 17261 224481 208595 70461 15183 20185 217166 74343 12914 382056 56406 11909 640703 11947 75387 269951 20656 170826 64384 226153 50776 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs 16993 15446 11687 19225 11689 DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 96%5579019 Defective FMO3 causes TMAU 14262 KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization 626834 227937 20765 70166 13706 66203 317653 71529 69511 21816 20129 668304 66344 13507 13506 16480 13505 386463 99681 14027 12365 76770 19143 72432 67451 259277 16769 74176 19041 68668 76560 16939 20754 240633 56460 18550 18553 16678 12336 12333 13511 13510 18772 109620 13512 64058 117172 56735 77055 75706 26560 435286 320864 94179 406221 69533 629873 69473 109052 70810 223917 100039486 68673 670464 435285 66708 100041488 223915 406220 16681 16675 16663 16661 268482 16682 110308 16687 110310 16691 107656 100040248 16664 239932 16665 16666 16660 16670 16694 77914 66809 71369 435273 16667 16668 105866 16680 53622 16679 406222 71888 16671 16672 53617 114566 406219 100040249 546511 76444 268905 332131 170654 74127 237934 100039757 CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER 56389 193813 56494 14799 235416 66397 66890 69608 217615 218811 99683 338366 20703 70361 14067 77371 14275 12793 20334 100042773 20333 64138 21802 13032 12794 214895 14069 11839 333883 72978 12836 100042343 50907 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation 64658 66419 64660 78523 94061 623346 102060 50529 233870 100040519 68565 99045 66973 69163 52443 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 70316 67681 66399 108853 64655 211253 107733 320806 68537 17721 18100 17722 67707 17716 94066 17717 60441 17718 218506 17719 66230 17720 68463 67871 65111 74600 107734 66242 28028 68735 622268 27398 94067 28030 67840 68836 79044 94065 57312 75398 68572 67308 64659 56282 66292 24030 66121 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 17711 17708 17709 17710 239555 69606 76784 17705 76366 67851 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 96%202670 ERKs are inactivated 21770 73699 101568 235584 67603 19052 319520 72349 19053 51792 23939 26413 26417 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020933 Interleukin-23 signaling 20848 16160 54721 20849 209590 16452 18453 16161 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere 22589 13163 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 96%1810476 RIP-mediated NFkB activation via ZBP1 56532 69721 58203 19697 106759 71966 12675 16150 18034 16151 17874 18033 18035 13211 18036 142980 19766 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 96%3371497 HSP90 chaperone cycle for SHRs 56444 56445 67665 56455 22428 13191 12344 59288 20867 69654 14229 193740 14228 15481 15519 234663 12343 81489 12345 235661 11835 12340 14815 100043508 68097 54130 110784 53598 58233 13427 18667 15502 13426 13424 15516 15512 15482 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins 12234 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19645 19177 21402 26443 26444 12566 19170 66413 26965 56371 667035 27401 22190 59029 67089 70247 30939 18005 20877 12428 229776 12237 67141 107995 12427 56150 21762 22123 20878 19179 19181 19182 217232 23996 56317 12236 19184 59008 18817 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 96%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs 75619 21379 380601 NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 96%927802 Nonsense-Mediated Decay (NMD) 622534 238217 14852 16785 666669 100040021 67025 100043391 326622 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 67031 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 19052 100042740 19951 51792 667618 100040970 267019 56040 67248 100040331 67941 57294 68092 433702 192160 208643 60365 68134 192170 19826 66441 17149 667035 75901 19704 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 233789 71978 65019 103677 629957 226517 20102 74133 229512 20103 71997 668668 667739 14853 672214 66481 225058 100038875 100038991 68028 225363 100043000 67891 100043295 18458 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 14708 14706 14702 14704 14696 14695 73341 14693 64337 14709 14697 14701 14710 14699 66066 14700 18479 14688 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669936 Sorafenib-resistant KIT mutants 16590 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors 328572 26885 109113 19763 223701 100040573 20602 54383 67040 13619 17977 19017 241915 12416 17978 17190 224903 18148 19821 13163 268903 15258 12914 13207 106021 56469 21849 59004 30951 20610 22196 12418 20466 100043429 57320 229615 13016 12151 69260 22658 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 96%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) 20533 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 96%1474228 Degradation of the extracellular matrix 20750 12550 24087 21892 12153 16621 12505 13038 17395 268958 13039 12339 17392 15530 23830 17394 17384 56213 17388 23948 58223 17229 72947 50817 83995 269120 72902 18550 170725 64706 11502 240047 11501 17391 381122 73647 268935 12335 12215 12338 30800 12337 12334 23993 12336 17385 17381 71753 69543 12380 12333 17228 11487 11491 12367 18073 12817 12816 22072 12821 107581 77018 12819 16776 16777 16780 12822 19164 226519 12841 16782 12823 11490 12840 59287 16774 12818 140709 13040 237759 12839 13030 17386 50701 232345 23794 13033 30806 271127 208936 66473 17390 21858 21857 11504 18815 17387 17389 17393 13035 240913 12032 13179 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism 18950 15452 11486 11821 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels 242425 14702 14696 16519 16520 54393 14697 16518 16516 14710 14699 66066 14700 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 14693 16517 64337 14709 14701 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS 108652 23971 23972 268512 13521 73836 231583 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 13110 13850 13078 72303 107141 13077 13076 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions 74134 13087 13107 13106 72303 107141 13088 56448 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling 110596 11848 14810 22612 76709 19353 73178 16885 16886 56443 11461 14360 68089 67771 12631 15529 11867 56378 66713 74117 545156 16443 17096 14812 19877 218397 21844 14083 15461 11465 19878 18479 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 56438 667035 13871 16881 22190 66420 67439 69833 67710 245841 69920 20022 14885 66983 209357 71101 66467 71991 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 23894 14884 11834 12848 27015 69745 100043806 26891 59001 319955 22594 26754 16882 19687 19718 69263 66979 56031 26893 21399 18538 26894 28000 13870 68275 108679 106344 72151 18971 68240 18972 252870 22590 19891 18973 26572 18974 22592 50505 26895 67967 57905 13716 99375 72584 13194 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport 68453 65107 67442 15530 67861 11806 238055 11816 16956 665270 103978 63857 17252 55938 105349 14733 22139 11807 239393 11808 15529 11603 23888 20971 79235 20969 16835 14734 170752 11813 11814 69060 77337 109791 83702 19662 14725 71951 20970 19660 16971 14735 19659 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 96%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 71481 667035 26416 211550 22190 17258 20203 26410 26409 20210 24110 26413 103583 257632 26417 26940 266632 26401 80750 223664 107607 19094 69721 102626 231130 93834 270151 73699 11596 22059 26395 67454 240518 71966 110651 108960 20112 59025 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 170743 14281 12370 17087 21770 22030 12475 67245 26399 225471 106759 26400 18034 26398 26420 13712 26414 26397 17260 434174 21898 66513 93765 23939 66589 22034 66724 68652 20111 11909 26419 12675 16476 18033 18035 18036 11820 81897 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 22589 13163 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.4 Response to elevated platelet cytosolic Ca2+ 11472 12331 18643 18787 239273 16002 16000 12491 12527 22371 16416 16784 14161 21894 21825 56744 110135 99571 22330 109711 54216 11806 667310 640703 385643 268373 19156 15234 18752 22041 14828 19128 13645 11820 14456 72017 57349 18751 22145 16399 14268 11818 27359 12258 21346 20716 268936 192176 18591 117586 11674 109232 71946 12759 215789 235505 67988 12321 11537 18613 26968 68038 20912 20911 21922 20255 108101 218454 223601 12512 80718 16426 22138 227612 232345 60595 104009 320202 70945 53612 67059 11657 20703 11625 20909 21767 19073 56541 74145 14067 12631 14205 80884 20344 68117 21859 74840 94175 13041 20363 11747 21857 16427 18815 56193 18816 21803 19039 21808 56055 13601 240334 14069 20692 22388 75396 22341 22339 18407 22340 11804 18750 71660 67072 21809 66866 27999 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME%R-HSA-9924644.2 Developmental Lineages of the Mammary Gland 11839 21802 13645 14165 19109 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 96%9010642 ROBO receptors bind AKAP5 18747 19056 268902 18750 19087 238276 18749 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602410 TLR3 deficiency - HSE 142980 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 96%9614657 FOXO-mediated transcription of cell death genes 328572 14103 12914 17684 54601 18044 18045 56458 18046 13198 56484 20869 12053 12125 68943 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters 208890 320718 23985 13487 268512 13521 231583 171429 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 96%5669034 TNFs bind their physiological receptors 21943 14103 171211 85030 50930 21940 21941 21949 21948 21936 16992 230979 13608 13607 21942 21937 21938 18383 21935 240873 69583 24099 57916 22163 22164 245527 326623 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 96%168164 Toll Like Receptor 3 (TLR3) Cascade 66105 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 21770 26399 26400 26398 26420 13712 26414 26397 17260 23939 11909 26419 12675 16476 18033 18035 18036 11820 12234 56480 54131 19697 21402 73086 16150 16151 192656 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 80750 223664 107607 69721 231130 270151 11596 22059 67454 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 142980 19766 11797 56532 22030 22031 56489 11796 106759 21353 18034 71648 54123 434174 100041766 14082 66513 93765 66589 22034 66724 68652 20111 216080 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 96%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 56436 17463 57296 20422 26445 26446 19172 19173 22628 19175 19177 56438 12567 26443 12443 26444 19170 66413 667035 22190 59029 67089 70247 13001 26554 13000 100039026 20747 21762 22123 19179 19181 19182 23996 19184 26440 60533 19166 19167 26441 26442 69077 66997 23997 SIGNALING BY MAPK MUTANTS%REACTOME%R-HSA-9652817.2 Signaling by MAPK mutants 75590 235584 18218 67603 63953 70686 26413 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 96%9706374 FLT3 signaling through SRC family kinases 20963 14256 15162 16818 14255 14360 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) 20505 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) 332396 ADENOSINE P1 RECEPTORS%REACTOME%R-HSA-417973.3 Adenosine P1 receptors 11539 11541 11540 11542 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%8851907 MET activates PI3K AKT signaling 18708 14388 15234 18706 17295 NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism 230718 268782 50773 103850 22271 67464 12495 12499 12496 12497 215446 14544 53893 72090 66358 75686 76952 381101 93685 16434 22436 214254 18950 56045 23959 64705 76654 72962 99586 103149 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%392154 Nitric oxide stimulates guanylate cyclase 58802 242202 18125 18127 23984 241489 18585 17540 18574 54195 18573 72413 60596 207728 16531 16533 234889 18126 19092 435726 16438 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition 69675 19303 16398 12558 13612 12550 21417 232313 20674 68292 18787 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 12021 81601 327762 20422 233826 19361 114714 22427 19362 11920 12189 12190 237911 57434 19360 225182 26909 17535 21975 19363 19364 12144 27354 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME%R-HSA-9909505.2 Modulation of host responses by IFN-stimulated genes 23806 52668 56791 74153 13666 71586 230073 100038882 12675 16150 15061 217069 16151 14229 14828 226641 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME DATABASE ID RELEASE 96%5658208 Defective SLC5A2 causes renal glucosuria (GLYS1) 246787 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610783 Degradation of GLI2 by the proteasome 12234 93687 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 56637 667035 22190 59029 67089 70247 18747 21762 22123 14633 19179 18749 19181 19182 23996 19184 26440 19166 24069 19167 26441 26442 69077 66997 23997 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-HSA-5654716.3 Downstream signaling of activated FGFR4 327826 14172 80857 14170 14180 14177 64654 14175 18176 14388 20662 14173 14164 15461 83379 107971 18803 80903 18708 19247 14186 18706 CELL DIVISION%REACTOME%R-HSA-68884.6 cell division 71175 74549 100710 218914 20842 19348 18817 71819 71521 24061 20843 19357 13006 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation 23825 319583 22596 14375 15361 101739 108138 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME DATABASE ID RELEASE 96%5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) 107723 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME%R-HSA-5609978.5 Defective GALT can cause GALCT 14430 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 20924 23894 14884 68092 433702 20922 20833 67655 21399 107951 57314 114741 76246 214498 12454 66317 58202 235497 67923 22083 27224 27632 24116 12455 72949 54624 13716 64144 20926 93736 70122 74427 73473 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-HSA-983695.6 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 269717 18707 12143 17973 58194 234779 109305 12483 22324 20963 22063 12229 17060 20866 12518 15985 229709 14360 16438 16439 640703 15170 16440 17096 20662 26377 12478 18708 83490 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis 17350 232440 319149 12567 12566 15077 13404 26972 19183 217716 76915 55993 17687 94244 20842 22196 213389 28113 15267 101185 319168 319167 19360 24061 17535 21975 19357 319186 15512 27354 319178 319183 60530 319182 319190 19361 114714 57321 319176 223697 319181 11920 12189 12190 319152 21749 497652 225182 21750 12144 13006 381306 68275 68240 19891 319169 625328 56739 78303 140557 319188 50878 15270 20962 74075 16906 320558 64009 319565 71846 624153 66654 20957 75459 20843 77053 382522 PROTEIN HYDROXYLATION%REACTOME%R-HSA-9629569.1 Protein hydroxylation 269955 77035 67014 65973 66521 71952 270086 13495 107817 667739 69082 14071 100038875 225363 665189 13494 194952 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface 18173 11977 11927 72621 PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation 18747 640703 224129 19088 11512 11513 11514 19087 19084 11515 18749 104110 432530 210044 104111 19085 DEFECTIVE CYP21A2 CAUSES AH3%REACTOME DATABASE ID RELEASE 96%5579021 Defective CYP21A2 causes AH3 13079 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 96%8849468 PTK6 Regulates Proteins Involved in RNA Processing 20459 20218 13992 170771 71514 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-HSA-8981607.3 Intracellular oxygen transport 17189 114886 64242 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%169911 Regulation of Apoptosis 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 78514 74143 67089 70247 67013 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 224105 26441 26442 69077 66997 23997 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) 74571 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 96%5683371 Defective ABCB6 causes MCOPCB7 74104 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins 93687 71164 53618 20448 227619 19089 13200 208884 667035 12330 22190 22196 66357 20014 103963 56637 69038 13135 15469 103534 67075 57377 27801 228136 75965 70546 20817 14423 108687 20815 214424 269181 328417 57437 606496 217664 67287 69035 80285 107895 52552 20446 671535 20444 547253 20442 80286 20443 17308 17158 68292 20440 67569 16430 14376 20447 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 96%192823 Viral mRNA Translation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100037258 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 27207 67097 670832 231413 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 96%2173782 Binding and Uptake of Ligands by Scavenger Receptors 12843 15129 12842 15122 12282 71693 11806 12317 238055 11699 15458 11816 15439 192188 16069 93671 434174 11657 20210 20202 192187 15519 14325 12491 20288 117158 140792 71145 12827 17167 12826 12825 380713 11801 269855 14319 15505 16971 20692 18477 22027 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 96%5687613 Diseases associated with surfactant metabolism 27410 12984 12982 20387 20390 20389 20388 20531 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.4 Negative regulation of FGFR1 signaling 327826 80857 14180 12402 14177 67112 24064 64654 17346 14175 14174 14173 14164 19052 109880 19053 51792 667035 22190 19247 26413 26417 14165 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 54124 56436 20459 17463 57296 20422 26445 12428 26446 12575 19172 19173 19175 19177 21402 12567 26443 12443 26444 12566 19170 12447 66413 26965 667035 27401 22190 12448 59029 12576 67089 70247 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling 17202 17201 20779 22094 12640 18754 18755 320127 26413 76192 26417 104418 56077 66082 22325 231871 380921 110524 269060 110197 217480 13139 331374 140498 212108 57257 19773 242093 18176 381489 20662 19877 239336 16336 15461 23919 52666 16800 13605 109689 19878 216869 213498 207212 71704 234094 56349 16801 11852 75547 72754 69632 213649 24001 224014 230098 53972 30938 21390 77669 442801 226970 235611 54126 101497 14673 269608 640703 328967 14163 19055 26382 19056 268739 19419 14674 73341 11550 11853 19058 11548 11549 12568 11820 109934 11554 11555 11556 15560 15559 15558 213788 15557 13492 382348 13491 381853 13490 14607 13488 14697 111174 215855 503558 54598 215854 12672 12671 19226 15552 14710 15466 14699 15551 66066 14700 243764 12669 93896 15465 18241 14708 209512 14706 15566 15565 12310 15563 14704 15562 11516 225192 14695 14652 11517 12311 14693 64337 14709 15874 12921 12918 14701 114640 223780 54409 19227 19228 56089 213527 51801 14602 14601 11535 14702 14696 14527 14526 19088 19108 12267 104110 22354 14678 14677 12229 22353 14687 20287 14679 432530 210044 22355 104111 19057 14688 70086 224129 11512 11513 11514 11515 18749 11541 242851 19085 58861 12322 12323 108058 12325 229709 16438 16439 18798 18747 16440 73699 110651 20112 19052 19053 51792 21770 14680 55984 19418 54393 23939 21844 207565 18752 236915 242425 18429 11998 18430 54140 26361 12000 14685 212541 20210 15139 12266 104709 207911 18750 23797 18796 18797 14686 18795 12326 320207 19084 11651 11652 22324 18710 13649 14419 12772 12774 12768 30955 80901 18708 18709 84112 18479 20607 387512 18706 12776 18607 12775 12458 12773 12771 170458 18386 18389 14539 19214 243270 239283 387513 19222 14427 19217 18166 19218 19219 18167 18168 14294 12802 14293 12801 14309 387353 387515 353148 12765 227288 14308 56838 57811 17773 244701 353165 387348 387356 19156 20605 19065 20606 19064 80885 12145 20609 20608 14428 13051 227289 217212 208990 110326 83770 20132 140795 57349 30878 17329 20290 11848 17200 102098 18155 55985 20303 109648 20304 12057 14675 20296 24012 57385 19739 20297 100039973 74191 50782 100038965 277360 13610 56066 20311 50779 20312 20300 11539 11540 18610 18619 11542 66102 13611 14672 622434 22095 330122 51791 14823 12922 14608 16412 108073 67839 545156 268934 23984 16443 94226 241489 14676 108069 19049 108068 67792 20310 58175 14825 18545 353344 218461 14429 18577 17207 14764 110385 13603 238871 11609 207728 23796 54611 14682 83771 18584 574417 67865 387347 71729 57253 18583 12777 80910 57254 381413 109904 387355 93690 387342 238725 230972 387349 626596 71223 12766 239530 226304 383563 387616 76123 321019 29863 12778 14761 381073 26385 110168 106512 223435 436440 76854 12769 15199 23945 14763 70839 19045 171469 16866 16867 227326 14739 12854 16952 15945 20315 12767 19087 20663 14459 53978 22044 22045 624910 57260 233571 235036 246709 13617 19734 30044 14715 14714 13615 18441 246691 18442 100039592 14745 16963 16995 208188 229214 56183 56696 210198 58182 19204 104443 224065 19216 19220 64214 319239 14816 14289 12374 108071 238377 14744 225642 50778 56744 19735 50780 19736 14829 67168 21333 11606 11607 12061 12062 17392 56470 216749 21338 19737 14064 65086 14063 14062 14061 21337 15200 23832 319197 21334 21336 240816 12424 12425 12426 217369 227717 14065 381810 107221 280287 24111 574402 78134 100043254 237362 385643 433292 246313 233079 233080 233081 50501 67405 18216 14773 54615 12209 78826 114229 15171 110312 18217 387285 230777 11551 14767 11552 68039 11553 18101 56533 18576 22065 18387 18390 18751 22068 26946 18753 18783 110355 18575 18574 18573 16402 12273 20604 18761 19395 20111 320129 13616 13614 18976 17199 13618 17203 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine 19703 245847 54342 109785 56174 14583 107652 14584 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-HSA-5656169.2 Termination of translesion DNA synthesis 56791 59001 74153 19687 100038882 19718 69263 22224 66979 26447 56210 68026 216835 667035 22190 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 80905 67967 217069 27015 69745 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation 233833 13626 18854 66894 72607 68031 73162 11651 19720 11652 21951 74493 14302 52615 17999 19646 234366 26413 26417 21907 13001 13000 100039026 56233 245688 12418 23942 17192 14013 12151 19763 54383 13619 241915 12416 19821 15183 66508 545987 54170 11909 52187 494448 68576 66096 83409 74370 68441 21762 30951 22123 268706 19179 19181 245670 19182 23996 19184 16476 99377 26440 19166 19167 26441 26442 69077 66997 23997 216848 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 107932 26443 26444 19170 66413 667035 19211 22190 59029 67089 70247 19712 22059 19016 13498 68877 76850 239528 229542 236511 20613 56424 56717 11798 13653 213988 217351 214150 15184 99982 217864 116871 116870 20583 14056 252870 17454 433759 56716 15182 54484 23797 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 96%5632968 Defective Mismatch Repair Associated With MSH6 17685 17688 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking 73178 18127 13430 12389 329416 HATS ACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%3214847 HATs acetylate histones 21427 15161 109115 66233 58523 269424 78656 73247 225895 319149 74026 20174 77766 54351 74195 72341 217031 107435 226976 230233 208146 77853 269003 21761 76719 15077 76901 17692 102162 223527 140858 56790 382207 56397 69612 11461 72195 101206 28019 27878 13486 71777 217588 217127 108946 75565 228714 67773 245688 216825 621893 319162 100683 15267 319173 319163 319168 319167 75560 13831 268936 319186 319178 328572 319183 70088 319182 81601 228829 246103 108155 319190 17977 319176 56456 319181 17978 216185 108143 66464 56505 66262 12753 244349 12914 78783 11909 14534 319169 18505 18519 78303 319188 319189 64050 382522 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 96%6811555 PI5P Regulates TP53 Acetylation 328572 23988 219024 26399 22059 18718 69260 108083 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 96%4839744 Signaling by APC mutants 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM 20531 COX REACTIONS%REACTOME DATABASE ID RELEASE 96%140180 COX reactions 19224 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3645790.4 TGFBR2 Kinase Domain Mutants in Cancer 21803 21812 21813 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 96%3371511 HSF1 activation 68275 68196 269523 68240 15185 19891 22627 100043508 15516 15499 15519 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) 19743 METABOLISM%REACTOME%R-HSA-1430728.16 Metabolism 68267 107508 13371 13370 70337 12389 213696 114479 16922 107585 22094 12908 214593 17117 99439 67528 66811 13142 106200 74114 12640 110959 22018 70503 18102 18103 229363 228061 27416 15112 22436 56185 214254 80911 76263 15452 13850 22017 12012 100042069 111175 14863 19193 23917 93732 14923 20280 67689 171210 11611 212503 56794 67224 15516 66999 13244 73690 11605 96979 20869 14667 18655 66612 108098 109652 66172 22318 20614 20907 192191 78334 73166 231070 270669 110196 14137 100040592 20683 66397 18044 18045 20933 18046 235293 68603 69608 218811 14732 99683 20775 20249 235623 192156 67131 170439 15484 72999 15483 13121 12401 20788 110695 13360 218865 107476 74129 100705 192166 14593 381379 55990 16987 14262 17764 71949 56453 75292 77371 101540 319554 67630 17855 230379 20334 67219 239559 53897 76893 66190 432628 74442 66183 171168 338521 20773 77626 26879 22234 14421 545975 14420 241447 104725 66844 56632 19012 50784 22239 18760 238011 230101 433323 76199 70059 208449 54447 670717 67260 67916 227102 268656 228677 93898 242083 223753 81535 70750 20397 76303 71720 228983 12642 15486 66065 114664 14187 99031 71240 100273 20520 17118 69718 227112 17330 57423 21428 53420 66477 11958 11957 11684 76491 11947 56362 319655 11949 20859 242291 68055 20860 23827 17705 73671 11946 29859 15526 20887 170442 66043 235386 11950 56442 192289 100041835 66194 100039108 71562 432676 69051 228033 209027 98256 209176 11847 100678 434437 53814 12716 107766 242669 76722 54375 26943 12715 20810 30956 230779 671878 75986 70789 229905 16514 56720 194237 217593 108653 67432 104174 83885 102857 76238 27364 19249 218442 23923 20229 209692 67092 229709 574418 16438 270076 16439 12971 266645 18747 107272 18247 18242 18245 12491 236539 56752 15930 18263 16440 22166 14630 76408 14775 17436 18104 14859 109778 233016 107765 12896 14629 12895 68041 19224 66198 264895 77219 14200 12408 14073 66834 18979 67420 57279 76187 330260 98314 269823 217666 70025 243168 71985 52538 72482 18803 11688 78245 69573 64292 102632 68680 14373 66469 228859 56360 330450 94185 171281 74156 245533 13167 223722 329910 195733 19225 11689 20927 76768 69060 109791 56045 76500 14411 234967 17254 20539 19341 20444 20442 20443 329416 14792 329502 66857 271844 67452 237625 665270 270084 53357 67216 68255 232889 225845 70625 68975 234959 69574 246696 68021 94112 11670 12350 12352 70208 12353 12354 56078 13849 76459 237940 23831 11754 67758 73046 109857 67712 22171 18105 14751 21877 71934 13361 67247 66394 56771 66112 50493 80509 108083 98386 14776 56310 26896 103988 19156 12857 110323 12861 12862 12868 66142 12866 12865 100041785 19211 333182 216456 380975 67279 59027 17992 18718 16866 11864 12289 18478 64384 70266 14204 110391 13180 66514 18534 170749 11816 59024 327987 20135 20182 69065 75475 13885 14872 54486 68252 66054 14862 14865 14866 68312 100042314 14874 14871 68044 68214 219024 78797 26426 68523 72199 26425 26371 67563 109006 69790 12858 14660 170826 20463 14381 14377 16334 75613 17708 17709 17710 14431 26379 20787 56508 264064 223864 84682 11863 20527 216154 51813 69792 20466 67381 19015 20602 23989 109731 28077 382985 171285 29875 27053 16993 15446 13087 13107 13106 622127 11624 11622 72303 107141 13088 13077 56448 13076 13114 74134 72082 13110 13113 545817 11428 27413 15369 19300 26357 18670 68421 28253 20544 230099 12040 12041 67725 13171 66422 13382 320685 12039 93692 55936 20133 66588 78801 51797 21915 11636 11637 229949 635960 79059 56520 54369 68870 64705 76654 72962 99586 103149 230718 268782 100017 50773 103850 68453 22271 93835 57875 13082 22259 16956 65969 232174 11303 546726 17252 66113 105349 13909 11657 18807 11807 11808 11632 16835 11813 11814 18749 15926 68961 338362 76969 74637 109754 328779 109672 23971 54338 23972 20522 319415 78923 11676 18682 14387 11677 18295 76898 68631 212898 14385 114332 56043 108105 66646 14595 15277 15275 17022 78752 75612 192188 50935 60322 269941 108902 80908 218271 14264 105193 14121 19746 545291 14120 70484 110078 22333 110095 19309 23908 15529 23888 20971 14635 74246 319625 224674 83493 20969 77980 14422 67073 54613 224020 56398 77116 14430 15587 216558 216019 15442 50917 16548 71951 20970 19139 54371 66171 71797 14735 12505 268512 100043349 71336 231583 53412 75456 19895 235582 212032 14043 14042 15531 226265 15530 77559 110639 13521 27419 73836 56336 56386 13806 103978 18563 235504 74241 66681 54616 16770 58193 80982 14733 21991 20524 53374 13070 83398 50786 17160 13808 77590 13807 108652 93683 13853 68365 68401 231727 20525 14734 116847 20322 319901 64580 117592 67883 59031 57370 53418 21351 56305 56375 215015 26878 26877 54218 50787 270198 18641 73744 18642 26384 12183 14378 18639 18640 170768 102448 76507 18648 71761 56012 107239 14348 15186 15366 15109 21881 243537 70974 140483 15118 67383 15117 14317 15116 64385 17159 21391 56421 19223 72136 13124 110173 100042622 58250 76205 18663 59045 54710 12257 628779 170459 235534 20845 225913 67980 50785 232493 14936 74185 27357 74468 110208 74551 11603 16545 233781 217119 227327 67880 14345 231103 53625 14344 14343 93961 11668 15476 72157 15478 27029 195646 17423 14347 280645 18679 56773 110094 102093 72727 234356 232449 67544 27047 230753 58810 11674 72141 230163 13072 15492 60525 15497 72535 13079 11529 68738 11522 26876 11532 11669 22227 12683 12686 15108 75894 18950 229665 109674 11717 105446 11534 11486 11821 66355 13178 27369 214424 328417 67287 80285 52552 671535 547253 18750 19092 18796 21990 18797 18795 17161 19084 19125 56189 212647 69089 12288 100042811 28250 107029 27418 70456 74125 16833 226757 76282 109801 16832 381511 68263 228026 18604 236900 27273 68477 75387 18004 66089 27402 68636 106557 18597 18598 382051 319518 16828 66771 55951 76425 59003 109264 235339 64436 18805 22139 624814 56384 22072 104158 68202 56491 108037 23945 75497 16890 19045 64899 21884 14626 14933 67469 215456 14245 19046 234729 103968 54384 66905 17772 64898 320981 13350 216724 12140 210376 16204 66569 16592 241274 14077 240752 233549 18705 67800 234129 14571 50767 68393 18720 14079 68616 14080 18719 75772 97287 11770 233315 11842 106869 107650 103199 244882 18711 12169 233552 268783 69769 74302 53332 219135 84095 319934 240753 101490 231999 109135 19062 269180 66443 234515 83435 83436 101476 56209 56409 75678 102954 27399 271424 227399 71207 327655 19087 238276 225742 20910 26938 19025 57357 50877 20454 11686 23801 625249 18010 23956 12709 13166 18948 21823 13195 17113 11840 13430 67768 108645 57344 67674 238505 11720 232087 210009 14873 269378 18113 12846 11551 11553 75669 225326 74159 12780 11364 67460 13177 66853 18631 68801 21835 14311 14081 20186 13123 104086 13122 77337 208665 101502 83702 21452 15288 22276 12892 17025 11655 11656 14151 226139 22275 19044 70383 14854 320634 20526 74411 74754 66234 18194 110460 68865 13595 15490 17001 67442 19088 234779 12499 73178 104110 14678 14677 432530 210044 104111 224129 11512 11513 11514 11515 15485 14598 16971 319446 23959 23887 19085 13479 12495 269437 104015 16330 16331 16332 269615 18798 18799 72469 18802 217837 228550 74055 320404 114875 104759 233011 212933 63857 55938 79235 170752 245532 65107 67861 239393 26940 102294 19662 19660 12894 19659 69923 19063 257633 433256 83603 74522 54397 50790 15487 328845 74205 57874 14979 30963 104112 106529 54325 66775 94180 216739 74559 234309 243078 70757 56348 99035 26568 54326 77582 56727 114663 55980 71780 212111 16329 103236 18127 64291 56473 76267 22273 66694 100042918 66576 53893 14297 66358 67530 75686 544717 56046 100040287 380840 17711 22272 66152 75530 67267 66821 100900 72795 107197 66445 67003 21743 214580 20768 211006 50880 20226 14711 65967 75420 20494 20493 106407 330962 26459 170460 71519 106648 100040843 13078 20751 71365 67426 99138 17979 320415 14528 242642 76889 217707 230027 67914 19286 56075 12850 71883 227683 52064 100043508 68268 22236 57813 67464 108147 69719 11564 11566 12496 12497 215446 14544 231327 237823 67365 72090 22247 80914 22245 68556 76952 381101 93685 11565 72269 56749 16434 67054 14450 56705 97212 11363 231086 12038 12647 11423 17961 94215 72094 213012 394436 12286 394433 22235 12290 71773 100727 100559 56808 231396 394434 94284 12296 552899 12297 223337 242585 243616 17960 14645 19215 99712 236899 12651 237928 56018 212862 12660 13026 76574 106861 18559 18618 69219 114886 66427 18777 21762 22123 20598 67041 58994 19179 64059 19181 69772 19182 208982 23996 110446 19184 15360 78894 26440 71911 19166 15356 13190 50500 19167 22293 18431 26441 22173 22178 26442 69077 74776 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 117147 22260 20181 22337 19013 19883 18783 59004 19016 22196 100043429 240332 19141 19731 269400 20597 18739 237911 74596 19679 327958 52858 74121 18971 26922 22229 22228 20523 74011 13075 109905 17164 217214 11898 109900 227231 18408 18416 67824 11846 19014 229003 11865 52466 328572 15368 21372 109151 11806 17977 238055 19017 18143 30960 17978 59035 81004 66826 66993 19301 24001 12753 15183 20185 217166 12914 15929 56406 67105 640703 74147 11429 171282 11666 68033 26458 15488 12856 113868 170789 26378 12974 67264 100434 213603 242259 229517 70129 66885 68682 12035 12036 66948 58875 104776 14697 12671 14710 14699 66066 14700 14276 14708 14706 110826 14704 14695 14652 14693 64337 14709 14701 14702 12182 14696 14527 14526 14688 29873 68133 13003 110006 77042 15586 109685 70893 15212 15211 12032 13179 15932 12091 11881 15931 12111 121021 13004 244757 19047 19386 73699 107146 233799 233801 272428 435528 19052 19053 51792 445007 64918 246277 21770 66902 14261 12583 57294 12411 67870 211389 12116 67873 14719 14718 66071 73748 70316 107869 56369 104923 27376 246221 17721 211488 17722 22117 17716 56551 17717 59010 17718 226654 17719 79196 237542 69912 28042 70568 85031 74182 105501 103468 27281 102278 67078 71760 74451 12891 75320 234865 66461 68671 218121 226856 320951 59015 66586 69736 668257 192654 74486 116939 66727 110379 266692 110911 67103 320997 13120 11690 631304 11687 13118 72054 17250 19210 208285 27388 13871 110821 66904 17850 73724 109136 104816 11484 269642 72560 68165 14149 14148 77697 109129 67096 18181 75778 13081 108156 17769 11433 216225 319945 71707 67375 52710 246703 225994 68591 107747 103711 69568 27973 29807 17434 74080 68646 110948 104709 78914 66473 69564 268566 105663 11761 230125 102570 223646 66454 54219 26363 67512 100039707 108079 14712 192185 18779 20509 239759 69698 26971 69372 108097 333433 69906 108958 17768 99010 54391 210992 116914 14555 270685 26970 20425 26565 67993 215708 67795 102247 226518 18784 216188 18782 14603 78390 216134 66350 67283 231510 665563 52123 12494 114874 67895 28169 76429 68262 66659 18806 55979 225010 18778 72297 18108 320207 58805 11651 68465 11450 72674 18710 11886 244209 11298 216343 13001 13000 100039026 11520 228775 108099 30955 18708 18709 18107 18706 74769 18707 436059 72947 11409 93747 15107 20216 271457 12346 12349 12351 14466 240444 30805 14675 238076 14672 14447 14676 22059 16500 268345 14682 20698 170762 108989 231042 227699 223921 227720 269113 66679 18141 107939 69482 71805 11739 54563 19069 70699 72787 18226 218210 11370 229211 27207 225887 67097 72900 670832 226646 17995 633683 595136 20044 623286 27050 66706 667279 235169 20085 78330 668144 67899 20084 210582 67186 170718 382492 66359 20055 52469 75617 66349 27370 76916 65019 69802 629957 75406 20102 67834 269951 20103 66945 668668 73694 667739 66343 66072 66841 672214 94281 66052 66481 67680 225058 66925 100038875 110842 100038991 74316 68028 70207 100043000 231430 67891 20930 100043295 66271 622534 67876 238217 66690 76826 16785 69702 666669 66278 100040021 208501 67025 54405 100043391 17991 668182 66091 241053 14194 69487 432502 110198 108755 71522 66272 19989 207182 239760 76808 71670 56451 19899 56615 68015 100043184 211666 20916 19921 66447 66414 19934 20917 100043755 67388 71238 68332 66379 319195 68472 100043209 104130 68193 75597 621100 66928 19941 18115 665189 15159 666899 68493 100042670 76947 15519 67044 100039316 67273 22121 68198 16211 66495 68002 67130 66416 68375 100043876 66108 100043893 52892 100043423 66836 100042986 68342 20115 76178 67281 66377 68197 76846 227197 625646 67184 100040298 100042503 68172 66046 100042740 230075 19951 66916 66218 15233 234724 19384 15445 667618 14085 100040970 267019 56040 67248 100040331 67941 11606 13116 13115 14104 110115 74450 56050 73095 18984 71743 75735 68087 211347 67618 269614 106564 72621 66812 73132 26464 22361 18605 18606 330064 209558 233081 26457 18293 78920 78038 243382 227095 11992 72039 56357 58911 22021 271970 67902 22022 545260 11883 74008 77041 216820 68346 14661 14473 94224 13074 78925 18704 107045 18717 15473 226414 257635 97541 231691 216443 105148 231872 20975 66143 14725 18976 104458 71803 67863 78830 85305 50799 17449 13722 17448 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 96%9759476 Regulation of Homotypic Cell-Cell Adhesion 233833 20665 12388 232440 19089 12387 13200 13626 11735 12550 319149 20586 19645 20779 13858 15077 104836 13345 12330 20901 21417 60611 52615 16601 114142 19646 26413 26417 21418 13001 13000 100039026 17869 245688 18109 22160 16480 22330 16600 66357 53325 17246 66286 228839 18550 18553 69019 93759 93760 13430 21762 56529 22123 19179 19181 19182 67956 23996 19184 105837 26440 13017 19166 13016 19167 15220 26441 26442 69077 66997 23997 56436 17463 57296 20422 24136 26445 26446 20683 19172 19173 19175 15376 19177 26443 26444 22431 21423 19170 14694 75339 66413 192173 667035 22190 59029 230738 18746 67089 76007 56805 21406 70247 21885 18554 227485 15267 319168 56198 319167 13040 13030 76850 77630 239528 11492 319186 239096 12385 319178 59058 319183 110751 319182 12564 15426 66624 16201 236511 20613 319190 330914 12552 57875 15227 319176 319181 20014 213988 103963 217351 214150 69038 13135 99982 76687 228913 20583 14056 18717 17454 319169 57377 625328 78303 319188 15270 433759 217734 99011 15182 624153 16430 14376 382522 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 15107 20216 11370 97212 11363 231086 11364 26922 11409 93747 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209931 Serotonin and melatonin biosynthesis 21990 13195 11298 216343 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 96%4724289 Defective ALG6 causes CDG-1c 320438 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 96%3560801 Defective B3GAT3 causes JDSSDHD 15529 11603 23888 20971 12111 121021 13004 20969 15530 14734 103978 71951 29873 20970 13003 14735 14733 72727 12032 13179 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 20459 13448 667035 22190 69710 12402 11651 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME%R-HSA-167242.4 Abortive elongation of HIV-1 transcript in the absence of Tat 20020 231329 20021 69241 17749 58202 100043714 68092 27632 24116 20924 433702 20922 68705 98053 66420 69833 67655 67710 245841 69920 57314 20022 DNA DAMAGE BYPASS%REACTOME%R-HSA-73893.3 DNA Damage Bypass 76843 22230 56791 59001 74153 19687 100038882 19718 56438 69263 22224 19714 66979 244666 269523 71890 26447 56210 68026 216835 667035 22190 68098 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 80905 67967 217069 217365 27015 99375 69745 22210 72584 58186 230484 13194 67561 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 96%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) 57765 21926 20849 18018 12399 22022 16162 15978 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693579 Homologous DNA Pairing and Strand Exchange 12021 81601 327762 20422 19361 114714 22427 19718 69263 15574 11920 12189 12190 235610 231724 237911 19355 57434 225182 74335 26909 235559 12144 68275 106344 72151 68240 233826 19891 19367 19356 19362 12649 19360 17535 21975 19363 19364 27354 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6791226 Major pathway of rRNA processing in the nucleolus and cytosol 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 55989 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 66362 67248 109075 100040331 66583 67941 27998 72544 50911 69639 72662 66446 227715 57294 104318 56200 72515 67676 27993 102614 50912 67619 66878 217109 110816 66138 229504 208144 67276 67973 18114 18572 78394 53414 216156 269470 59028 12181 21771 75273 215193 64934 217995 73674 67755 68272 213895 76130 216987 66249 353258 56095 71340 224823 102462 69072 213773 105372 67205 27373 72554 104662 67053 52705 230082 223499 269536 80886 70683 100041622 97961 24128 66164 27966 57750 74035 100608 100040177 234374 667035 30877 75416 57315 14113 68979 208366 227522 14791 57316 67045 54364 72198 65961 622491 68533 67134 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 SARS-COV-2-HOST INTERACTIONS%REACTOME%R-HSA-9705683.4 SARS-CoV-2-host interactions 16451 56208 16785 67443 78610 216799 22628 100038882 11651 12389 11652 15519 100039316 100039592 19386 54401 55948 20115 76846 100040298 233870 378425 267019 218978 218035 15516 445007 67941 18607 57294 269338 16172 22365 69912 80743 12914 28185 103468 15977 234865 71586 230073 66641 12675 71956 228607 59015 12695 217069 69736 224912 77573 14609 56217 110379 22627 24088 21897 75669 257630 56480 54131 225326 66397 107686 384091 171095 666609 216766 16150 15006 69608 218811 621705 21872 20595 16151 99683 66603 53975 192656 240095 276919 667803 20641 16179 23881 667035 20638 225913 69731 432803 26409 27041 67332 14991 257632 77371 20334 100039786 107607 20390 108960 12785 170743 228545 15007 170762 12010 108989 170744 231042 227699 223921 227720 269113 66679 18141 107939 17195 69482 71805 73158 54563 22031 71732 56489 19069 70699 72787 18226 218210 54721 72512 54123 233405 20847 66513 93765 66589 19247 22034 27207 15975 67097 66724 670832 68652 633683 16171 20044 27050 667279 15170 20085 668144 20084 382492 20055 22631 75617 27370 22629 629957 20846 20102 20103 668668 667739 66481 225058 100038875 23797 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 73804 19053 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 18817 110379 69928 13427 76499 13426 52504 13424 228421 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport 14702 11998 14696 11833 19088 12000 11828 19087 19084 11829 11830 11831 104110 14697 66333 14710 432530 14699 210044 66066 104111 14700 14688 18747 14708 17339 14706 208760 14704 11832 53869 64008 14695 11827 224129 11512 14693 11513 11514 64337 11515 14709 18749 17919 74998 14701 11826 19085 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 96%5173214 O-glycosylation of TSR domain-containing proteins 66548 330267 207596 224697 56229 239337 77794 279028 80294 108153 23794 30806 108154 210417 271127 229595 208936 77739 381694 269959 100689 233744 235130 240322 20357 11504 20356 18636 21826 226866 21825 240913 223838 237360 330119 216725 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602415 UNC93B1 deficiency - HSE 54445 142980 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli 20750 12387 12562 19697 19087 19084 16150 11651 16151 14697 54598 14710 63873 14699 66066 14700 14360 18747 14708 11350 14706 14672 18442 14704 16412 14695 22601 73699 14693 64337 14709 16416 19052 16402 14682 78757 21894 14701 51792 19246 54409 18709 18706 22330 58226 18607 74769 11535 18707 14702 14696 18613 12293 18127 15530 12295 12296 19088 12297 56489 56717 104110 109333 81904 227743 432530 55991 210044 104111 14688 640703 224129 109270 11512 11513 11514 71978 12675 11515 12306 20846 16410 12334 18749 14083 12336 14609 18033 69543 17387 18439 16542 14257 18035 56716 19085 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371598 Defective BTD causes biotidinase deficiency 26363 INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes 54483 15368 66824 216799 19697 18034 383619 268973 12362 18033 18439 22166 12043 67955 19200 56338 195046 55991 12048 11820 15516 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription 328572 12914 15213 14534 15214 18514 18519 218977 18131 18128 67784 333639 19208 211652 15205 20846 270118 15208 19664 56198 12140 103806 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 96%5666185 RHO GTPases Activate Rhotekin and Rhophilins 76378 100039683 14787 52428 11848 20166 11852 11853 22342 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 14377 54601 16334 11604 109648 56458 19017 110616 16006 433766 76184 103988 57264 14815 17126 17127 17128 67731 20466 20656 56484 18976 433759 20787 243743 64384 15182 12359 18534 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 96%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 56436 17463 57296 20422 232440 26445 20375 26446 19172 319149 19173 19175 19177 26443 26444 21423 19170 15077 66413 667035 22190 59029 67089 21406 70247 214162 11350 66671 17420 22601 12572 15267 319168 319167 16396 319186 319178 319183 319182 12400 319190 319176 14462 319181 14461 22062 14460 21349 319169 21762 22123 109594 19179 19181 19182 16909 23996 625328 19184 78303 319188 16825 26440 15270 19166 19167 17863 26441 624153 26442 69077 66997 23997 382522 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.3 AXIN missense mutants destabilize the destruction complex 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 18011 232232 13388 16449 240055 225164 20602 11487 54485 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 15213 56233 17869 15214 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 15205 19664 433759 15182 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 96%179409 APC-Cdc20 mediated degradation of Nek2A 52717 99152 668450 56150 12237 107995 217232 18005 56317 12236 59008 66156 216080 667035 69957 22190 17222 75430 68612 52563 22194 68999 52206 100039535 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events 19662 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid 20148 19378 237320 13082 98711 12903 56847 19682 242285 105014 232174 216454 546726 17252 11522 108841 26876 241452 105349 13382 16592 218772 19411 28200 20181 20183 20182 68263 228026 18604 236900 27273 11668 27402 18597 19401 18598 19015 12904 235339 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis 245533 216820 228061 67420 14712 245532 330450 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-HSA-2173788.3 Downregulation of TGF-beta receptor signaling 68010 17872 19047 65112 14479 56424 170749 56207 17126 17127 19045 103573 21803 83814 75788 66313 21812 19046 667035 21813 17131 22190 20901 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9932444 ATP-dependent chromatin remodelers 232440 12387 319149 67155 20586 240442 13445 11538 269610 20588 106795 20587 22780 14025 22779 78266 228880 52004 15077 17191 233410 11819 22778 140858 622675 70998 14121 19646 234366 83766 16002 56811 245688 23942 17192 70802 101631 73503 12006 67772 328572 67959 109151 107701 239985 210982 105246 72047 243842 56456 17135 20833 66993 18104 18024 114741 22026 76246 71389 214498 12914 66317 212880 21413 93760 235497 66923 22083 17927 17928 54624 68479 20222 216848 14377 319322 27967 107686 384091 666609 12412 107932 70127 29861 68981 269397 21423 20639 19708 268996 20641 101943 20638 12055 81898 12054 11461 77045 20646 67332 21406 26992 22196 68094 83796 15267 83797 57376 319168 319167 66055 229542 319186 319178 319183 319182 67465 319190 319176 13018 72293 67958 319181 241128 320790 76479 75062 12648 244059 116871 13204 116870 76938 66125 319169 12417 625328 78303 319188 15270 433759 15182 624153 72057 77044 58208 18534 382522 ACETYLATION%REACTOME DATABASE ID RELEASE 96%156582 Acetylation 17961 17960 NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717301 NVP-TAE684-resistant ALK mutants 11682 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling 13866 13649 18183 83961 100042150 12223 14388 13874 15200 211323 13645 18708 18706 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 96%1237044 Erythrocytes take up carbon dioxide and release oxygen 19743 15129 15122 20533 230582 266690 320635 12346 72017 12349 12351 11826 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9033807 ABO blood group biosynthesis 80908 14344 14343 DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance 22589 13163 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA 23825 15361 101739 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 96%4641263 Regulation of FZD by ubiquitination 239405 228770 407821 14367 207742 84092 14160 14366 22416 14370 107515 192199 667035 22190 72780 14368 16974 16973 329252 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 96%8986944 Transcriptional Regulation by MECP2 233833 13388 19293 20393 20602 12326 14811 20674 94223 17295 12322 12323 22065 16179 108058 18387 19211 12325 18390 18747 14431 26913 19016 12918 20877 19246 268859 76850 239528 98386 19258 236511 21372 20604 15228 213988 81004 17260 14229 217351 214150 56310 15183 14800 20185 17433 15258 20527 640703 17454 12064 14812 20466 14415 14417 433759 15182 15194 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME DATABASE ID RELEASE 96%5250989 Toxicity of botulinum toxin type G (botG) 22317 22318 20979 VITAMINS%REACTOME DATABASE ID RELEASE 96%211916 Vitamins 546726 13115 13081 13082 244209 232174 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351200 Interconversion of polyamines 20229 212503 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 96%9766229 Degradation of CDH1 56436 17463 57296 20422 12388 26445 12387 26446 19172 12550 19173 19175 19177 20779 26443 26444 19170 13858 104836 14694 66413 667035 22190 59029 67089 70247 13040 16480 13030 12385 53325 17246 13430 21762 22123 19179 19181 19182 23996 19184 105837 26440 19166 19167 26441 26442 69077 66997 23997 UREA CYCLE%REACTOME DATABASE ID RELEASE 96%70635 Urea cycle 217214 11898 83885 109900 227231 18408 18416 67824 11846 68346 22059 11847 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2122948.5 Activated NOTCH1 Transmits Signal to the Nucleus 18011 13388 16449 240055 225164 12805 11487 54485 207521 11491 16450 18128 667035 22190 227325 13386 74198 18222 14357 19164 19165 100042305 208117 59287 100039623 76580 109689 216869 16396 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-HSA-2299718.4 Condensation of Prophase Chromosomes 319178 319183 319182 12534 232440 319190 319149 19645 319176 14211 319181 15077 319152 70099 244329 76044 78658 319169 52683 67956 625328 15267 78303 18817 319188 671392 319168 15270 319167 624153 319186 382522 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration 16402 223272 12400 17386 23797 11651 11652 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies 69772 208982 110446 15360 78894 71911 15356 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs 18141 23825 107939 69482 71805 54563 16646 19069 15361 70699 101739 72787 18226 218210 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 96%75067 Processing of Capped Intronless Pre-mRNA 384091 666609 68092 433702 20638 243963 67332 20492 72290 116748 68219 98985 228410 54451 108062 67337 54196 83410 18789 51786 94230 74320 68188 54188 66899 269061 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) 216848 319178 319183 319182 232440 319190 319149 319955 110147 319176 107932 319181 15077 22130 19646 234366 116871 116870 245688 319169 12417 23942 17192 625328 15267 78303 319188 433759 319168 15270 319167 15182 624153 229542 319186 382522 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 18747 640703 19088 432530 11514 19108 19087 19084 18749 19085 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 96%2025928 Calcineurin activates NFAT 640703 268373 19055 19056 18018 18019 19058 14225 18021 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) 13982 15510 107503 628438 11651 15526 20656 56484 193740 64704 15502 64384 18181 74142 12359 15499 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 96%69416 Dimerization of procaspase-8 14103 22030 71609 14082 22035 21933 12370 19766 14102 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 96%8847993 ERBB2 Activates PTK6 Signaling 20459 13866 15200 211323 13649 18183 13645 83961 100042150 12223 13874 INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 96%877300 Interferon gamma signaling 16451 54131 18854 15006 16364 12322 240095 12323 667803 108058 12325 17967 26413 14991 26417 55932 56469 12265 74735 18753 22329 20821 19824 23960 19204 65972 229900 110157 246727 17318 17750 231655 19246 93679 15007 17131 12010 224762 16362 12505 236573 67525 16452 15978 54139 55992 16363 101700 12702 94088 80890 360213 54123 56631 16391 15980 22670 15979 319236 19247 15894 214158 14969 229644 14968 246728 15900 22608 229898 66854 15170 217069 27056 12703 14469 14129 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%8856688 Golgi-to-ER retrograde transport 28169 54160 74947 108148 16570 107338 66111 53357 73470 16563 16568 234663 213827 11844 68097 73804 67511 53598 56358 56444 67665 22428 56455 13191 12121 76895 12344 26951 18476 59288 16594 18475 229841 668303 16579 232943 19348 71819 16593 105785 16551 110033 209737 11840 74764 18472 235661 18195 108123 108124 270192 13427 19346 13426 13424 228421 17957 26934 240641 269152 16565 16564 16552 16580 16581 67023 16561 16562 72772 16558 70218 20932 75050 16554 286942 71116 16578 319991 16572 66251 224630 16573 16560 56447 54161 18783 77038 59042 69654 228998 68137 11843 19324 66913 12343 12345 100042773 20333 11842 16569 12340 50797 70349 16571 12847 54130 14423 226407 19330 76308 100042343 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 96%9615933 Postmitotic nuclear pore complex (NPC) reformation 103468 107939 16211 69482 71805 226747 234865 70699 59015 72787 22196 69736 18226 238799 110379 19384 170762 100088 227699 445007 69912 269113 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9635465 Suppression of apoptosis 606496 672511 13035 26413 26417 19720 71514 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196780 Biotin transport and metabolism 18563 78038 110821 330064 66904 72039 107476 26363 100705 110948 72621 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters 74610 74104 56199 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 96%5545619 XAV939 stabilizes AXIN 21951 74493 SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 96%9717189 Sensory perception of taste 20278 18796 20266 546729 20276 21906 20277 387513 399548 20274 16518 110876 20269 72821 387353 240669 387515 353148 68667 14688 353165 387348 14695 268934 16440 56843 64337 83771 574417 14816 387347 57253 57254 110326 387355 83770 387342 387349 242851 387616 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 96%9735869 SARS-CoV-1 modulates host translation machinery 16785 57294 667035 27207 67097 670832 100039316 633683 20044 27050 667279 20085 668144 20084 15382 382492 20055 75617 20115 27370 629957 76846 20102 100040298 20103 668668 667739 66481 225058 100038875 267019 67941 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication 15516 15519 COMPLEX IV ASSEMBLY%REACTOME%R-HSA-9864848.2 Complex IV assembly 67876 12866 12865 66278 100041785 17992 66272 67388 66379 333182 67044 17708 17709 17710 67105 12858 67899 210582 52892 66359 66836 12857 52469 76178 69802 68033 12856 110323 66343 12861 20463 12862 70207 12868 231430 226139 84682 20930 66142 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 12261 12578 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 96%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes 12952 12914 214162 382056 19883 21425 20893 18143 19653 13170 217732 17691 12753 19885 18626 11865 18627 18628 217166 12953 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 96%166786 Creation of C4 and C2 activators 317677 14134 17195 12944 12259 71693 12260 12262 667277 239447 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis 14348 14345 14422 54613 14344 14343 93961 50935 80908 14347 26878 26877 54218 19746 20443 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence 12189 16881 17216 21752 17218 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions 16451 16880 12931 16878 100042555 18414 16195 16156 54721 218624 13019 12804 56708 12803 18413 16452 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways 20682 15901 17202 17201 12389 76804 22094 12640 19271 28200 22325 15925 57257 246710 50875 19877 15381 83946 106504 109331 11465 12848 19230 17920 22352 19878 76626 56381 19655 53382 15516 100043806 269061 26891 56320 109711 12539 20462 17395 69288 242202 18552 18550 18553 21812 21813 12283 20869 64930 13631 75705 66508 545987 13685 13684 18655 54170 72149 208643 22084 52187 68576 66096 83409 74370 68441 19042 268706 69008 67605 227154 245670 11789 20683 19205 76936 14732 27061 20249 71514 13385 15382 70686 53310 13383 59013 14939 98758 14102 14251 22195 22035 16396 12370 19766 11797 14252 22030 56424 21933 11796 11798 50701 12028 71609 14082 56321 17827 72843 68653 67414 70827 214952 229877 170731 319939 217169 67299 223701 11937 11938 53313 223870 12322 12323 108058 12325 19249 19253 229709 16438 16439 18747 320139 19255 16440 53627 20218 13992 170771 110651 20112 12418 14013 12151 17165 19763 17246 54383 13619 20293 241915 12416 319152 19821 23939 12579 106766 16193 494448 21413 17877 26419 17878 30951 17927 12064 17928 14812 14388 21844 18212 208869 18205 107971 78405 18803 11839 12043 13645 12048 18011 13388 16449 240055 225164 11487 54485 11491 16450 12562 16798 68473 75723 50523 232157 56332 64010 56274 58231 17005 14694 51789 58220 15139 21885 12266 227377 13653 20514 19341 57437 20443 260302 22241 208884 12326 18039 14810 11472 23859 14814 17886 72565 16370 15213 16002 67268 16000 13649 21802 74126 55948 94093 23942 67484 218214 11815 17122 21825 320982 68151 104263 231821 14419 12070 12772 56433 21815 12768 30930 80901 71785 14747 65114 84112 21827 387512 16765 59289 21828 108083 12776 214425 12775 73130 12458 12991 12773 12771 170458 98386 18386 18389 14539 23925 19214 243270 239283 12702 387513 14462 19222 14427 19217 228839 18166 19218 19219 18167 16477 18168 14294 12802 56310 14293 72780 12801 14309 387353 387515 353148 12765 218772 227288 19411 14308 56838 57811 17773 80707 244701 353165 387348 14534 387356 19156 20605 19065 20606 19064 211578 80885 272031 12145 20609 20608 14428 19664 227289 75769 217212 208990 216152 19650 22439 17863 110326 83770 20132 140795 57349 17171 30878 216848 623503 232232 107522 17329 20290 17200 18155 55985 20303 109648 20304 18129 20306 18131 20296 20292 18132 20302 107932 57385 20295 20297 100039973 74191 100038965 170787 20299 13610 53376 56066 19211 20311 20312 20300 11539 11540 18610 68428 18619 16184 229791 235044 16183 11542 252837 66102 13611 100039786 22095 19712 330122 19713 14823 108073 268934 94226 108069 108068 20310 14825 353344 14429 14764 13603 11609 23796 83771 574417 387347 19246 57253 12777 57254 387355 387342 387349 226278 229542 12766 226304 387616 12705 321019 12778 381073 23988 110168 75805 436440 76854 12769 64095 15199 17283 230857 14763 54199 18718 70839 171469 16866 16867 227326 14739 12854 13349 14229 15945 70315 93836 67821 13866 12345 18519 21858 21857 15370 15201 16323 16322 21814 21808 118445 67903 17387 11480 17389 21809 18534 268977 16997 22632 16998 20750 68010 17872 320910 20393 65112 14479 108075 18854 16420 170749 56207 241226 84092 79221 11816 66105 21907 11350 20482 20481 81489 20183 20182 75410 17125 67384 17126 17127 17128 17192 66313 17130 17131 56744 103806 333639 22284 22608 13559 104394 75273 14634 14633 75788 16653 12981 16334 56458 21423 16179 18387 18390 13983 21406 14128 21937 16399 12366 16402 21926 56508 264064 223864 227290 18591 12843 20807 54601 12399 20604 12927 83814 15185 12142 15184 12631 14205 51813 12156 252870 15469 15205 18815 20466 19015 20692 22341 22339 22340 15182 71393 20602 20586 56374 381293 20867 83669 18844 270118 108670 12874 232339 14786 223881 208994 108686 66922 12005 227937 20257 67586 234366 71228 18787 68187 93840 11671 107568 56233 15214 194231 54519 29875 245684 22371 16416 110157 23980 14161 21894 215449 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 16706 242341 68775 15369 76252 11972 108664 66290 18002 11964 110935 11966 100039636 66335 11973 11974 74915 338375 21871 73834 114143 66237 11975 54411 27060 140494 22042 66144 56480 207521 77579 71960 13856 16885 16886 13171 13382 12830 12829 12828 21886 12827 227325 12826 13386 21888 74198 14357 30941 22029 12841 229603 22258 268749 12840 106025 74256 263876 245026 21929 12839 12835 12834 12833 30924 20148 19378 237320 13082 98711 11307 12903 56847 22259 19682 18453 242285 105014 232174 11303 216454 11771 546726 11772 17252 108841 71770 241452 105349 218203 78514 19057 232910 11773 11812 11813 11425 18749 16188 16185 12984 12982 16192 16191 14595 54613 19373 19374 14573 103978 15904 14585 20811 11481 12622 269275 11479 99377 329251 68458 17931 19283 19299 11668 16846 13654 259302 223666 14270 117600 20671 56489 71648 11522 26876 14256 116871 116870 17390 67470 27409 606496 17242 14257 19719 225600 17305 18750 224143 19091 140484 19092 17136 18587 68585 18588 18377 18099 235402 18796 21990 18797 56437 14686 14066 18795 17095 14681 12570 15902 23938 268980 17172 54152 15903 14283 211770 19084 17936 17937 11682 11838 13656 13655 381677 54607 24064 17346 54426 68263 228026 18604 236900 27273 27402 18597 18598 235339 83490 27373 18596 93687 77647 18213 16456 21682 18762 16923 11848 17228 102098 19273 70737 71520 93742 14159 56513 14158 12057 23921 73086 18582 68146 22319 11855 277360 192662 263406 11857 14570 68813 19349 18805 624814 70584 56418 74334 56384 70361 233103 229658 544963 622434 16572 66251 16573 68202 12922 16412 545156 16443 13726 23943 75739 140579 628438 71782 17207 94176 330662 94190 16709 52331 218581 84004 21917 16324 56491 109904 238130 230972 20430 56419 380664 104445 56389 13836 59079 108037 69922 223435 330914 232906 56212 71435 228359 23945 19045 19046 103968 66905 12140 16204 16592 18720 18719 16410 14083 11352 53332 17974 20315 17925 14026 214230 13857 17973 12767 18186 23893 19087 12165 11705 20663 110542 218441 12154 241656 17129 71436 18121 18643 55994 18645 12166 12167 12168 11482 14314 19268 19280 21927 74194 64652 216197 12709 20355 233877 12223 229776 16589 71920 13874 13712 15200 18053 18412 19229 77125 74325 13430 69581 17082 238505 11551 11552 11553 80903 384783 240756 75669 94253 14186 213522 14165 329366 81897 56784 14389 20401 16367 233071 14172 75974 80857 12549 18576 58996 14170 66146 225326 214345 14180 208263 14178 192652 14177 239027 67112 70350 64654 74159 14175 71409 14174 74018 14173 106326 14164 244867 83379 70598 192192 319899 260409 16398 57778 386649 16400 226823 21763 216445 69710 211499 16194 244895 216831 268970 70719 328232 244418 101240 232201 73167 78816 228482 72729 104252 231532 68917 27360 69668 14218 71972 225358 214137 75415 171207 74734 71703 77038 228543 58804 56699 214804 269682 77006 223254 102075 66087 11736 23912 207425 19765 54004 73910 83397 269401 434204 207495 76763 94221 11858 213783 100038946 71085 545481 23853 210998 219140 226652 14787 11854 232237 27984 75089 76577 230654 66725 93695 75717 22192 22346 12703 54484 59009 17999 67588 75590 231474 18218 63953 13537 19252 240672 24105 106042 14587 14586 19197 14588 19262 15234 14181 72514 13017 13016 105827 195727 210293 50884 71709 18188 83767 170758 329165 109934 11876 106952 71893 13448 26934 110279 330177 75409 105855 242687 216963 386750 17969 20947 212285 237038 70497 320634 11308 20619 224480 11856 13058 241275 13057 108100 76117 218952 26431 17970 101314 17972 66898 71302 71544 13433 12261 18595 19164 19165 15208 100042305 208117 59287 100039623 56198 140580 19088 234779 19108 12267 76709 73178 104110 20963 14678 14677 12229 56443 14687 14679 432530 210044 104111 80987 68089 67771 11867 56378 66713 74117 13542 70086 224129 245880 11512 11513 11514 11515 13544 13543 22376 215280 68524 11541 242851 19085 58861 330319 76884 66894 72607 68031 73162 19720 21951 74493 14302 16186 18798 14680 55984 19417 19418 54393 211323 14402 14401 14400 14394 14407 14406 207565 57249 18752 236915 22342 242425 18759 192656 17874 14685 212541 17258 20203 20210 266632 100040260 101568 235584 67603 319520 72349 67095 73668 67661 207911 74682 73916 81896 77583 21821 83554 74201 20668 16568 234130 213081 73016 84035 228770 103236 56811 20680 24117 237222 14296 74499 207742 14160 20319 20377 20187 20675 20677 212398 100683 107515 192199 77578 68911 67772 380718 67087 80288 16974 13380 16973 20607 329252 73739 106633 72135 244585 20679 68339 239405 407821 18127 101565 27371 110350 230126 260305 16594 232943 245866 16593 74764 14797 73296 319642 19346 56382 51791 14608 67839 23984 241489 19049 67792 58175 18545 218461 18577 110385 238871 207728 54611 18584 67865 71729 18583 80910 381413 93690 238725 626596 192176 71223 239530 383563 76123 29863 14761 26385 106512 20851 20850 14784 67393 12648 320271 13033 99982 14228 18986 17979 193796 228913 13207 21887 15375 55960 268527 107351 26424 21786 22282 22278 100041004 100043508 18222 18016 76378 100039683 233406 68268 18187 12904 13429 12390 17393 22236 102193 67738 20739 20740 12805 640524 20742 20741 20743 103967 17967 80297 56705 50721 13710 399558 396184 56505 14254 18777 66552 76686 21762 432940 22123 20598 12675 52440 58994 19179 18201 19181 73218 19182 70178 23996 226016 19184 19671 18033 436004 26440 216169 19166 18035 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 66413 26965 667035 22190 18751 18654 59029 26409 67089 70247 22260 20181 14106 14313 66556 13982 11835 18753 14815 18783 110355 18575 208727 18574 19016 18573 19401 11489 244650 13498 18667 68877 98432 58988 15937 19731 218294 18611 140486 70727 21687 11600 18612 19732 81601 17532 76089 235072 171463 56392 67836 71746 14783 225724 16337 50772 20852 76983 12649 17179 18817 26563 216080 26564 22419 24069 100042343 12534 12388 12387 58194 12550 20408 12402 56324 20779 15239 20404 17295 20844 20405 13858 107746 109880 12929 26416 12928 56044 64143 18754 18049 18755 216148 320127 26413 76192 26417 104418 29857 56077 20416 66082 327826 231871 18211 380921 109905 110524 77480 269060 19094 110197 20418 217480 102626 13139 19730 331374 54401 116701 26415 140498 26395 212108 26396 19773 19762 242093 18176 381489 20662 239336 19769 16336 15461 23919 17164 52666 16800 263803 52428 13605 270163 20166 236920 13830 19014 16480 68743 20874 213498 70804 12704 243362 328572 110596 207212 19285 71704 234094 11464 21372 50768 56349 54216 16801 17977 11852 404710 13367 75547 103573 20868 268301 17978 320795 59035 109333 81004 72754 208846 17260 69632 17261 213649 24001 224014 230098 268903 53972 30938 15183 21390 20185 77669 442801 226970 235611 12914 54126 101497 14673 11909 269608 640703 328967 14163 19055 26382 19056 268739 19419 14674 18018 73341 11550 240168 11853 19058 11548 14225 11549 56484 16476 16542 16906 22627 12569 12568 11820 12125 14103 12532 20459 11554 11555 11556 15560 15559 15558 213788 18128 15557 56438 13492 57265 382348 13733 13491 381853 13490 14607 13489 22226 13488 14697 111174 93897 215855 19206 503558 54598 215854 22412 12672 216795 12671 19226 15552 14710 15466 14699 15551 66066 15550 14700 243764 22410 12669 93896 15465 22414 99296 22411 18241 14708 209512 14706 15566 22409 15565 12310 15563 14704 15562 11516 225192 14695 19060 14652 11517 12311 14693 20423 64337 14709 15874 12921 12919 22417 12918 14701 114640 223780 230674 54409 19227 19228 56089 213527 51801 13363 14602 14601 54198 319757 12385 11535 14702 93735 83428 14696 14527 20613 14526 14367 14365 18514 26364 218977 14362 67784 22415 19208 14366 211652 22413 21335 22416 16453 22420 22418 54721 14370 22354 22422 13609 14371 22421 22353 20287 14368 22423 14369 217864 22355 20890 19207 14688 22408 16147 110606 59040 26554 226525 18015 14272 320484 211255 240057 101809 54153 114715 114716 19342 19414 69601 19415 218397 114713 12575 360216 211586 13555 21781 12567 12443 12566 12445 13557 12447 20901 12576 14255 108911 73470 16563 75786 70454 216965 71876 234663 19047 15507 66977 320394 19386 102920 73699 11799 12015 52276 12371 12235 67037 20842 68097 16319 217866 19052 105782 73804 14269 19053 22379 51792 80837 20877 214459 381318 14467 24061 66871 52696 226751 26886 76088 66934 218756 18221 20732 445007 15451 19357 15235 226849 19882 225849 20733 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 13006 214498 18472 67733 103468 66468 76464 66442 67629 235661 235497 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 13426 52504 13424 228421 26362 20843 18429 11998 18430 54140 26361 12000 21873 13511 13510 21872 12367 109620 68705 98053 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 620393 19242 15267 319168 319167 14281 224105 75778 76850 239528 319186 22158 319178 70300 319183 271639 319182 240888 14632 380614 236511 319190 241113 14282 56717 319176 216440 319181 19353 213988 217351 56637 214150 227743 19247 13819 66753 104709 14056 15170 116891 17454 20338 319169 14451 109270 57810 15245 117606 105787 108079 20846 19079 20848 108097 625328 78303 319188 15270 16818 19082 56716 624153 23797 382522 233833 16451 21415 232440 18806 13626 319149 22628 18183 12633 320207 83961 16478 100042150 16842 76890 22612 11651 11652 22324 15077 269523 66310 18710 19303 140858 97064 18791 52615 21752 19646 213464 14360 12988 68525 13001 59056 13000 74239 100039026 104346 17869 230500 245688 13206 20747 22601 15251 17096 12638 23808 14580 18109 17444 78757 228775 60533 76580 108099 12006 30955 12774 18708 18709 18479 18706 18607 74769 18707 12487 12519 12524 21414 21416 18481 68092 94275 21374 433702 107951 19354 20201 20202 12454 235459 83602 58202 12455 72949 14609 16001 12466 13051 12468 22143 12461 14675 24012 19739 50782 56327 50779 11461 14672 14676 22059 14682 20698 223921 67938 17904 107589 214240 226861 24063 17880 19272 16206 239463 94212 16419 59069 16952 19248 14425 16848 21803 21826 667739 224116 67300 12757 17063 14459 53978 11545 22044 22045 624910 57260 233571 235036 246709 13617 19734 30044 14715 15519 14714 13615 18441 246691 100039592 18442 14745 16963 16995 208188 229214 56183 56696 210198 58182 19204 104443 224065 19216 19220 64214 319239 14816 14289 12374 108071 238377 14744 225642 50778 19735 50780 19736 14829 67168 21333 11606 11607 12400 12061 14104 12062 17392 56470 216749 21338 19737 14064 65086 14063 14062 14061 21337 23832 319197 21334 21336 240816 12424 12425 12426 217369 227717 14065 381810 107221 280287 24111 574402 51796 78134 100043254 237362 385643 433292 53817 246313 233079 233080 233081 50501 67405 18216 14773 54615 12209 78826 114229 15171 110312 18217 387285 230777 14767 68039 18101 56533 22637 72345 20674 22065 22068 57295 26946 19277 16775 16776 16777 16779 16780 226519 14268 16782 16772 23928 16773 16774 319430 12478 12273 66573 71742 76857 13043 233489 100041766 66513 13854 18761 22034 19395 66724 20403 233046 68652 11845 20583 20111 18717 17169 13859 22631 320129 13616 22629 13614 106628 18976 17199 433759 13618 16590 93686 77411 21843 21841 17203 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 96%168179 Toll Like Receptor TLR1:TLR2 Cascade 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 20201 20202 11909 26419 12675 16476 18033 18035 18036 24088 11820 21897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 21899 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 22030 12475 67245 18034 12229 434174 66513 93765 66589 22034 66724 68652 20111 12703 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures 18542 192897 69675 16403 12815 24087 12814 21892 12831 12153 12813 12830 373864 12819 53867 12829 12828 12827 12826 12825 12824 16780 12822 71355 12841 16782 18810 12840 16774 245026 13040 12839 13030 329941 12837 12836 12835 12834 16948 12833 12843 16949 12832 12842 94352 16950 67573 17395 13039 17392 17386 30800 12476 17393 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD 11666 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 96%4641257 Degradation of AXIN 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 68031 26443 26444 21951 74493 19170 66413 667035 22190 12005 59029 67089 70247 21762 22123 19179 19181 19182 23996 19184 66313 26440 19166 12006 19167 26441 26442 69077 66997 23997 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels 16513 56379 16517 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 96%5689896 Ovarian tumor domain proteases 12534 11848 360216 107260 22031 73162 16151 269523 192656 68149 667035 19211 22190 170711 54644 57783 22034 257632 226418 107607 13982 231130 71586 22059 230073 66889 71956 228607 217069 229603 414084 216080 21929 70675 11789 19766 PLATELET DEGRANULATION%REACTOME%R-HSA-114608.5 Platelet degranulation 11472 12331 18643 18787 239273 16002 16000 12491 12527 22371 16416 16784 14161 21894 21825 56744 110135 99571 22330 109711 54216 11806 667310 640703 385643 268373 19156 15234 22041 14828 19128 13645 11820 14456 72017 57349 22145 16399 14268 11818 27359 12258 21346 20716 268936 192176 18591 117586 11674 109232 71946 12759 215789 235505 67988 12321 11537 18613 26968 68038 20911 21922 20255 108101 218454 223601 12512 80718 16426 22138 227612 232345 60595 104009 320202 70945 53612 67059 11657 20703 11625 21767 19073 56541 74145 14067 12631 14205 80884 20344 68117 21859 74840 94175 13041 20363 11747 21857 16427 18815 56193 18816 21803 19039 21808 56055 13601 240334 14069 20692 22388 75396 22341 22339 18407 22340 11804 71660 67072 21809 66866 27999 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956551 OTC leader sequence variants cause OTC deficiency 18416 OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling 18796 18797 18795 12326 14675 19087 19084 14697 12322 12323 108058 12325 18390 14710 14699 66066 18610 14700 26413 229709 16438 16439 18798 18747 14708 14706 14672 100039592 14704 14695 14676 16440 73699 18753 19049 18783 14693 110355 18575 64337 18574 14709 18573 18577 110385 238871 19052 14682 19053 14701 51792 14702 21770 14696 14680 19088 55984 19108 19045 104110 14678 14677 14679 432530 210044 104111 19057 14688 640703 19055 19056 224129 11512 11513 19058 11514 11515 18749 207565 18976 18752 12568 18750 242851 19085 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 96%392518 Signal amplification 14702 14696 14675 70839 14697 14678 14677 26416 14679 14710 14699 21390 66066 14700 14688 18441 14708 14672 14706 14704 14695 14674 14676 18783 14693 64337 14709 14682 14701 227290 242851 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation 20437 99152 636931 668450 328234 56208 76608 19823 227738 74153 22201 79263 22209 74244 53323 140629 68497 70620 330369 23807 140499 59009 17237 50788 22213 67128 433766 22222 224938 22214 17999 98766 67615 19155 268470 67588 59026 107568 230903 66772 208372 76454 70093 329152 117146 65247 22215 65255 67345 81018 84585 67731 217342 142687 209462 78910 231380 14161 65256 70392 69807 76580 244421 22036 224170 240396 225055 218978 24105 232539 110135 56515 99571 170823 215061 67138 19822 17087 74132 67490 231670 672511 13039 226098 69754 224619 77113 14897 59044 12702 207952 70348 320118 170737 70928 56228 30843 68854 76294 211007 21898 72323 399566 30945 68098 100763 214931 20201 20202 67923 106052 24088 242960 21897 30838 30050 50762 66397 17969 56438 15006 69608 218811 99683 22319 20619 240095 50754 13058 667803 13057 17970 17972 14991 77371 20334 213980 21899 68628 50789 30839 22195 50873 16396 56424 14827 16419 12229 434174 57743 218203 17534 21354 21356 21355 93836 53421 20909 100043039 246278 66212 26554 211255 16410 71745 22210 14129 12317 66105 56371 27401 12330 80751 117149 12491 20193 66313 80898 107995 22320 21762 22123 12675 19179 19181 19182 23996 19184 75788 110379 26440 19166 14828 19167 26441 26442 75669 69077 17533 66997 23997 12234 56436 17463 57296 20422 26445 26446 225326 19172 19173 19175 19177 21402 16150 26443 26444 16151 19170 17874 66413 26965 667035 22190 59029 67089 103583 70247 117589 78541 69299 218215 94090 233902 69116 208650 73998 50760 20821 235320 242521 209239 74492 75234 66799 72194 67845 15204 69706 235439 57751 15007 13040 140630 12010 94091 217194 16924 22019 226541 65257 104184 19820 78913 242785 56791 68729 69010 16912 211949 19171 66743 12475 233040 231672 18744 50492 224826 231863 101358 12449 224023 109161 16913 83814 22193 71538 76375 19186 67455 19188 14794 100041766 217217 216150 71999 269529 93765 83962 66589 230654 635668 240028 66515 269514 78889 69162 68431 230904 28105 71865 380928 20333 50868 207215 22200 627648 207304 75717 70294 67921 100041484 22192 66663 142688 217232 243574 56317 321006 59008 268291 209200 66156 74646 216080 448987 69957 22346 17222 56736 228003 68612 52563 12703 22194 212919 71393 68999 54484 52206 20439 100039535 218793 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 96%9936686 Aggregated β-amyloid interacts with fibrinogen 14161 110135 99571 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399710 Activation of AMPA receptors 53623 14799 14802 14800 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 96%389356 CD28 co-stimulation 225849 74769 53859 18707 26931 12487 21770 12519 26932 12524 18481 320207 56717 22612 11651 11652 19353 22324 18710 227743 26410 14360 104709 73699 109270 17096 19052 17444 78757 19053 228775 51792 16818 224105 30955 56716 18708 75778 18709 18479 23797 12477 18706 226849 18607 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation 16785 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 100039316 20115 76846 100040298 13665 67204 267019 26905 67941 57294 75705 27207 67097 670832 13684 633683 20044 27050 208643 667279 20085 668144 20084 382492 20055 75617 27370 629957 20102 20103 668668 667739 66481 225058 100038875 18458 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 96%2514853 Condensation of Prometaphase Chromosomes 13001 68298 13000 100039026 215387 12534 70099 12442 14211 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203754.3 NOSIP mediated eNOS trafficking 66394 18127 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors 242425 14702 14696 14680 16519 16520 104110 54393 14697 14678 16518 14677 16516 14679 14710 432530 14699 210044 66066 104111 14700 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 224129 11512 14693 11513 11514 16517 64337 11515 14709 14701 242851 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.3 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 232440 20602 319149 23989 19645 66853 59024 11450 14732 18631 327987 15077 57435 20249 68801 66310 21835 140858 14311 68975 14081 234959 213464 12606 20181 11350 28077 70208 12491 21664 55982 171285 23808 11520 56771 15267 319168 319167 19014 264064 319186 319178 328572 319183 319182 67279 319190 21372 16475 231051 57875 17977 67278 23945 319176 19017 16890 16956 319181 17978 81004 14245 69790 56310 103968 26896 15183 20185 93759 17979 216154 67800 12914 56406 51813 11770 26424 319169 22289 27273 69792 67512 625328 67381 78303 319188 15270 170826 12568 624153 381022 382522 SIGNALING BY PTK6%REACTOME%R-HSA-8848021.4 Signaling by PTK6 20459 13448 11848 12402 18183 83961 100042150 12567 12443 11651 12566 12447 19303 667035 22190 12928 69710 12576 71514 13649 20218 13992 14815 170771 15251 140579 18176 15461 330662 19246 140580 232906 12223 12702 13874 19353 12927 15200 211323 13819 20811 66725 106766 93695 13866 75273 218397 20848 13645 APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 96%75153 Apoptotic execution phase 12387 12550 20230 21873 13511 13510 27061 21872 12367 18772 109620 13512 227753 269582 16211 18753 19877 12369 14453 11518 13169 18810 12368 22352 56702 224105 50709 14957 12370 50708 14958 11797 80838 13368 16646 13347 97165 434174 70415 18761 223255 56215 74006 14272 12169 14083 16906 11789 20740 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation 14268 16402 16412 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 12234 93687 56436 208583 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 26416 22190 59029 67089 103583 70247 19094 12795 50883 56637 21762 22123 19179 19181 12649 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 12530 23997 27373 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System 53381 70450 12654 13014 102595 170813 14190 74153 12796 76905 67912 53328 74244 71728 53323 76025 229574 12508 12514 78892 68724 26949 232413 27261 433375 235627 19074 19271 19263 18126 72461 18103 17523 70152 52633 217353 19276 69981 22325 59026 667301 231887 72042 69660 71869 72065 394252 100042069 78388 21946 23917 16970 227960 57257 67689 74287 223978 19877 100037283 11571 208795 380924 245126 11465 20568 383295 69807 241197 67213 18813 83768 69189 17025 18703 268379 107767 15516 100040018 13244 93726 54159 56318 55950 70536 17395 21930 100040603 56444 20195 212114 53856 18600 11593 74039 73690 56016 18475 545878 16783 80796 54672 108888 17064 11605 56031 66222 96979 69550 13861 12283 20972 71517 69537 381812 14667 66508 16678 545987 19264 80860 67862 66612 20409 28185 74012 19288 76299 66060 14824 83409 83433 108015 18521 22177 20614 50884 24088 83767 21897 329165 23845 105855 242687 17969 15006 11308 20619 13058 667803 13057 108100 17970 101314 17972 21899 12261 56485 19164 16176 12362 59287 12363 15162 140580 17002 16396 12370 19766 11797 56532 16173 22030 67245 69146 234779 11796 17918 50701 12267 76709 53378 73178 20963 54722 434174 12229 56443 14082 19200 13205 80987 68089 67771 11867 54483 56378 66713 74117 245880 14191 22376 215280 18439 68524 67955 13035 17882 14129 17913 246256 14131 17909 66824 330319 216799 76884 14302 229709 16438 16439 24058 18747 117149 12491 73914 18125 20193 16440 104759 110651 20112 620235 19695 22166 74096 18489 12652 16429 18843 19194 78416 228801 57757 242100 26399 11927 26400 26398 26420 259301 26414 26397 228796 76113 11758 75526 384997 23939 15977 26419 18803 12043 12048 13629 11487 192656 17874 17258 20203 18746 20210 24110 11689 257632 26940 266632 15139 26401 14962 80750 12263 223664 12266 53791 625018 107607 69721 231130 93834 270151 11596 67454 240518 71966 108960 67781 59025 100040260 101568 232714 235584 67603 319520 72349 71884 104112 71955 57437 108995 19089 53357 66848 66557 17886 71481 211550 14751 12772 12458 13038 22154 13039 18127 16854 13036 67065 74414 226977 14293 78929 12765 26939 227288 67486 70408 20018 69870 70428 218832 67005 20016 19156 12909 16004 319642 19346 57349 330122 80910 23988 19258 13033 12343 57264 12340 21858 18016 11783 13429 69562 20740 103967 66105 269116 72269 11350 58992 19339 16621 13002 21762 22123 12675 52440 108723 19179 19181 19182 23996 268973 19184 18033 26440 19166 18035 19167 18036 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 12042 66413 26965 16179 667035 22190 240354 59029 26409 67089 103583 70247 16408 14127 18753 21938 12366 170743 13040 19141 56338 170744 13030 17535 22027 20716 54445 227290 12359 142980 667277 117586 239447 317677 14134 17195 12944 11537 16904 18613 12259 71693 12260 12262 19090 384309 22040 383619 12512 72162 72935 72512 54123 68891 20852 268857 22596 104009 13211 14375 214763 20703 11625 20527 12631 56619 332579 26888 56644 94175 381809 17312 56620 17474 13032 245828 216080 333883 18407 12387 26416 12928 18754 26413 26417 29857 109905 19094 102626 26415 26395 18176 29875 20662 15461 17164 110157 13169 14161 215449 11846 13830 16480 13505 110135 99571 22330 328572 15129 16993 17087 15368 238055 13367 20868 30960 17260 21898 242341 68775 15369 76252 11972 108664 66290 12914 14325 11909 640703 11964 268373 19055 110935 19056 11966 19419 100039636 18018 66335 18019 11973 11974 19058 74915 18021 14319 338375 21871 73834 26458 16476 114143 113868 66237 11975 27060 668218 16819 77674 11820 140494 654464 266620 654459 75400 66144 246700 71902 246082 654460 654465 12333 244332 56480 629114 446099 54131 207521 58203 68682 67526 11793 16885 54644 74256 21929 12182 58222 67963 26364 11772 232345 381925 18807 71910 12798 17319 19342 19336 70349 18749 15926 110006 109754 15212 11676 14387 12091 11881 14595 75612 18793 227753 110078 110095 109154 73699 12371 18436 19340 15442 50917 19052 19053 51792 12505 66934 212032 21770 56455 77559 71665 66681 231507 70568 19325 68365 235661 216238 71398 27056 78287 266692 19128 217303 18641 67474 13424 19152 76507 18648 17159 13510 15439 12367 110173 18772 109620 11891 225913 66420 69833 245841 27357 20932 17749 11977 100043714 16409 72157 16423 16411 16414 15267 319168 319167 14281 224105 50770 105722 232449 319186 11674 11980 319178 319183 319182 319190 12475 22031 56489 225471 106759 319176 21353 76295 18034 71648 319181 19353 19247 18950 15170 11717 235606 319169 223646 11821 67075 67512 625328 78303 319188 210992 15270 16818 624153 216134 382522 53859 18806 13200 319149 22612 22324 15077 269523 20719 11886 18792 26410 14360 22165 13001 12502 17096 12504 76501 16784 17444 12238 18708 18709 18479 18706 18607 74769 17394 18481 19354 20201 20202 240047 11501 74125 71586 230073 66641 71956 228607 217069 19345 19344 19261 108078 20343 12469 12461 21682 58217 11848 19698 15896 73086 170786 227613 13010 11461 51788 19349 18805 22139 52588 668101 11870 217304 22072 544963 217306 16643 232790 16498 22059 140579 17380 16790 94176 330662 70495 52331 52855 83382 20430 27007 17079 16803 329547 17084 56212 55991 13350 16592 269328 12306 16410 14083 17829 18636 100039649 140474 224116 17063 17925 73732 17973 353328 100038882 56615 12331 193740 15519 16211 100037258 19025 19204 68197 14289 20813 18010 216197 72621 14061 13712 22361 22320 100561 15481 385643 105245 64138 13430 54473 16822 75669 81897 14389 16428 56743 225326 227394 18173 28240 216445 70719 11883 69116 14126 14125 20821 22370 230558 319430 195046 12010 12258 110382 12478 12520 69379 12279 50702 11767 12628 23912 71756 12759 12630 56791 93721 12273 12274 545366 17221 56373 76763 12902 109828 100041766 216150 66513 76577 93765 66589 18761 22034 19395 66724 233046 68652 52120 20111 14569 22200 106572 22192 80861 108086 12703 19330 224794 67706 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-5651801.3 PCNA-Dependent Long Patch Base Excision Repair 68275 106344 72151 18971 68240 18970 18972 14156 59001 11792 19891 18973 18974 19687 19718 69263 67967 66979 16881 69745 18538 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%2565942 Regulation of PLK1 Activity at G2 M Transition 12234 20873 68121 12534 78887 22628 21402 225745 231123 227613 74360 22153 26965 18536 667035 22190 22142 66296 214552 103583 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 16475 101565 19088 16328 219103 230376 69654 71648 17274 83922 75296 26370 19046 76707 77744 219072 13589 225659 18472 76478 78177 28135 12442 214444 76816 20878 54130 18817 381644 13427 22627 17931 13424 27373 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 96%9935598 FXIIa, PKa activate coagulation factors 385643 58992 16621 14071 14723 14724 54368 14729 109821 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 96%68952 DNA replication initiation 66979 18969 18968 59001 19075 19076 18973 18974 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism 19895 230163 11881 14377 15931 14385 27419 75612 667035 105193 22190 232493 14936 74185 27357 52120 13853 67880 68401 69983 50917 27029 16548 21351 110006 226413 15586 14387 53412 15932 12091 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions 14609 67300 13429 11773 12757 13430 13132 74325 SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL 66586 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions 14205 14254 16542 22341 14257 22339 18654 22340 ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 96%3371568 Attenuation phase 328572 12914 81489 100043508 68196 193740 14228 15516 15512 15481 15499 15482 15519 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 96%68875 Mitotic Prophase 12534 232440 319149 19645 15077 18751 26413 59046 244329 59021 382030 67121 56205 52432 76044 19386 78658 73699 13726 66352 59125 67181 59126 52683 217718 70231 19052 15267 19053 51792 671392 319168 319167 170762 108989 231042 227699 223921 445007 227720 319186 269113 380664 66679 319178 18141 319183 23825 319182 107939 69482 71805 319190 54563 19069 319176 70699 72787 18226 319181 14211 64899 218210 319152 14245 70099 101706 64898 19324 69912 103468 22367 319169 224640 74498 234865 12442 59015 69736 67956 625328 78303 18817 319188 110379 15270 56041 16906 18750 624153 99412 76308 382522 SEPARATION OF SISTER CHROMATIDS%REACTOME%R-HSA-2467813.4 Separation of Sister Chromatids 52717 99152 668450 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 30939 218914 12235 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 100710 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 21762 22123 60411 66336 59015 19179 69736 19181 67052 19182 232987 23996 12236 19184 236930 110379 26440 69928 19166 13427 76499 19167 71521 13426 26441 52504 13424 26442 228421 69077 20843 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 105988 217232 56317 59008 18817 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%3000170 Syndecan interactions 15529 20971 109711 60409 16412 20969 21923 16410 14173 16416 21803 16419 192897 20970 16398 21825 12361 22370 16403 18750 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 75705 13684 208643 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 13665 67204 26905 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 18458 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 96%5579017 Defective CYP11B1 causes AH4 110115 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling 21814 21803 21808 67903 21812 21813 109689 216869 DISEASES OF HEMOSTASIS%REACTOME DATABASE ID RELEASE 96%9671793 Diseases of hemostasis 14067 19123 14723 279028 109821 22371 14061 14161 22021 14069 56316 19128 14058 14071 105722 14724 22022 54368 110135 14729 99571 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 96%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV 12040 13171 13382 12039 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 14389 74769 16367 14172 80857 18576 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 327826 16370 16002 16000 18176 14388 20662 15461 16001 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 214425 18607 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins 18550 19128 14058 14071 19123 14068 66901 14456 14061 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-HSA-5654699.3 SHC-mediated cascade:FGFR2 14172 80857 14180 14178 14177 67112 64654 14175 18176 14174 20662 14173 14164 15461 80903 14165 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 26459 26458 17117 13116 105349 56050 104086 77337 208665 101502 83702 13124 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%264642 Acetylcholine Neurotransmitter Release Cycle 63993 233977 20508 12647 19339 22318 20614 20979 68507 20907 327814 12889 22249 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432047 Passive transport by Aquaporins 11831 17339 208760 11832 64008 11827 11833 66333 11828 11829 11830 11826 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME%R-HSA-5659996.4 RPIA deficiency: failed conversion of R5P to RU5P 19895 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH 14598 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex 16998 68010 17872 16456 320910 18762 65112 11848 20602 14479 102098 108075 20683 70737 16420 93742 211586 170749 56513 12402 56207 241226 21781 11545 66105 667035 97064 22190 20901 26413 18787 26417 20482 20481 19047 17869 16412 94093 17126 17127 17128 16416 66313 17131 21815 264064 328572 12843 56424 17283 22284 19045 103573 228839 16419 83814 18550 16477 21812 21813 19046 107951 93836 20185 67821 12579 22608 12454 18002 13559 104394 51813 19042 14225 12455 72949 16410 22192 21803 21814 21808 75788 433759 216080 19650 21809 268977 16997 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 96%5602498 MyD88 deficiency (TLR2 4) 17087 117149 12491 21899 20193 12475 17874 14161 12229 434174 21898 24088 21897 20201 110135 20202 99571 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 13388 16449 11487 54485 11491 16450 18128 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) 216227 HYALURONAN METABOLISM%REACTOME DATABASE ID RELEASE 96%2142845 Hyaluronan metabolism 114332 15366 56398 15118 15117 15587 15116 192188 20544 235504 110006 77042 15586 80982 109685 12505 15212 15211 27416 74468 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K 71707 69568 27973 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9028335 Activated NTRK2 signals through PI3K 18212 78405 18708 12064 14388 18706 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 96%162658 Golgi Cisternae Pericentriolar Stack Reorganization 59021 12534 18817 56041 74498 66352 12442 26413 99412 76308 19324 70231 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 96%9754119 Drug-mediated inhibition of CDK4 CDK6 activity 12444 12445 12571 12567 12443 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs 16590 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion 14702 14696 56808 12296 12297 14697 14678 14677 14710 14699 66066 14700 14688 14708 14706 14704 12289 14695 224129 11512 14693 64337 14709 14701 11551 11553 12288 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629597 Highly calcium permeable nicotinic acetylcholine receptors 11438 110834 110902 11435 11440 108015 108043 11444 110835 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%9637690 Response of Mtb to phagocytosis 18655 16211 672511 12721 70686 16646 15239 13806 19720 606496 233405 271457 667035 22190 13035 19349 18126 26413 26417 108664 71514 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 96%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 11739 433923 11740 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME DATABASE ID RELEASE 96%5619063 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) 71279 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 114143 11964 11966 11886 100039636 66335 11973 11974 11972 108664 66290 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse 13866 67268 67938 17904 11848 11852 11853 17880 19877 77579 71960 20354 16885 16886 223881 69632 17886 19878 213498 235611 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants 14389 110279 20846 20851 20848 20850 75296 360013 432508 21848 67529 13047 18708 76007 18706 IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 96%9732724 IFNG signaling activates MAPKs 110157 16451 15980 15979 16452 26413 26417 15978 SOMITOGENESIS%REACTOME DATABASE ID RELEASE 96%9824272 Somitogenesis 56436 13388 17463 57296 20422 26445 12387 26446 19172 19173 19175 21389 19177 18128 16842 26443 26444 19170 84653 56184 66413 17293 13389 59029 67089 70247 13838 21762 22123 16848 19179 19181 19182 23996 19664 19184 26440 19166 19167 26441 26442 69077 66997 23997 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK 68275 106344 72151 68240 19891 19687 19718 69263 19714 71890 56210 667035 22190 27015 18538 RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events 242864 77974 79235 14539 19659 12057 22139 19682 11304 19771 20897 19662 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 96%198753 ERK MAPK targets 21770 20111 19094 73699 73086 110651 20112 13712 101568 235584 67603 19052 319520 72349 17260 19053 51792 26416 17258 23939 26413 26417 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 96%2029482 Regulation of actin dynamics for phagocytic cup formation 17913 246256 17973 14131 17909 105855 242687 330319 76884 11308 22324 16885 17886 108100 12928 11461 101314 26413 26417 15519 22325 11350 12502 57257 140579 330662 11465 140580 20430 18479 15516 17918 76709 19353 73178 20963 12229 56443 80987 68089 67771 12631 11867 56378 66713 74117 245880 14083 18016 22376 215280 68524 50884 17925 83767 17882 14129 329165 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196849 Metabolism of water-soluble vitamins and cofactors 21452 13361 52466 14104 74450 68214 73095 71743 75735 68087 211347 67618 269614 106564 72621 66812 73132 18563 26464 22361 18605 18606 330064 209558 19300 20525 68421 238505 210009 14873 18113 78038 72039 17250 107476 100705 14276 22072 110821 66904 17850 109136 77697 109129 67096 100017 12182 108037 93835 59027 108156 17769 11433 216225 65969 319945 67375 52710 246703 225994 68591 107747 103711 29807 17434 74080 68646 20527 110948 78914 66473 69564 268566 105663 11761 230125 102570 223646 66454 54219 26363 100039707 192185 20509 69698 69372 69906 14725 214424 17768 328417 54391 116914 67287 80285 270685 52552 20425 109754 671535 67993 109672 547253 67795 54338 226518 20522 23959 216188 14603 216134 67283 665563 12494 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159230 Transport of the SLBP Dependant Mature mRNA 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 69912 13684 103468 20492 19386 234865 59015 69736 21681 110379 170762 108989 53319 231042 227699 223921 227720 445007 269113 66679 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 12532 78893 69125 234594 18983 12795 22059 219103 52846 53621 231464 20620 72068 18148 12227 232791 104625 66214 58184 228140 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) 64176 22317 64051 22318 75209 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 96%9700206 Signaling by ALK in cancer 16367 12575 78798 268980 13666 108147 215114 19645 12211 19043 21402 56438 19084 14025 16364 11682 12047 70297 16153 18148 17886 26965 667035 22190 26413 26417 327826 16573 13433 19386 22059 238037 14939 67533 14268 16154 14235 22160 18646 108989 54167 232679 18708 18709 81910 76850 239528 18706 22330 74769 672511 236511 17246 13191 26420 20850 54721 59069 18412 14784 16477 217351 214150 16593 17210 69162 15170 380928 17454 26419 116849 12608 27267 20846 20848 16476 667739 107971 67300 433759 18803 21787 17698 22637 67160 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 20848 15234 17295 NUCLEOTIDE SALVAGE DEFECTS%REACTOME%R-HSA-9734207.3 Nucleotide salvage defects 15452 11486 11821 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%1280218 Adaptive Immune System 20437 99152 636931 668450 328234 76608 56208 19823 12387 227738 58194 74153 12550 22201 79263 22209 74244 53323 140629 20404 68497 70620 330369 23807 140499 59009 17237 50788 22213 67128 433766 22222 19271 224938 22214 17999 98766 67615 19155 268470 22436 67588 59026 107568 230903 109905 66772 208372 76454 70093 329152 117146 54401 65247 22215 65255 67345 81018 18176 84585 20662 217342 142687 15461 209462 110157 78910 231380 14161 65256 70392 215449 69807 244421 22036 224170 240396 225055 24105 218978 232539 110135 56515 99571 170823 215061 328572 67138 19822 17087 74132 67490 231670 672511 56444 226098 67665 19041 69754 22428 13191 224619 77113 14897 12344 59044 207952 59288 70348 320118 170737 70928 56228 30843 68854 76294 211007 21898 72323 399566 18024 30945 68098 100763 214931 19264 12914 640703 268373 19055 19056 19419 83433 18018 18019 240168 19058 14225 18021 22177 16476 24088 21897 110351 26934 66397 17969 56438 69608 15006 218811 99683 20619 240095 13058 667803 13057 17970 17972 14991 77371 20334 21899 22195 12526 50873 16396 56424 234779 14827 11771 11772 20963 71770 434174 12229 218203 17060 12518 15985 26554 232910 211255 11773 19260 18749 22376 22210 14129 269717 246256 109305 12567 12443 56371 27401 20866 229709 16331 73470 16438 16563 16439 18747 234663 117149 12491 20193 140792 16440 73699 26377 68097 19052 73804 19053 51792 226849 225849 26931 21770 26932 56455 229841 80898 107995 235661 110379 19294 18803 13427 14828 13426 217303 13424 228421 17533 192656 17874 12266 15898 22329 16421 65972 16414 78369 21679 15267 21676 319168 21678 319167 14281 224105 226144 547431 75778 238555 76850 237754 239528 195349 319186 12231 21677 319178 319183 319182 193670 54197 236511 319190 26754 12475 241113 14282 56717 70377 319176 69654 18034 216440 319181 19353 20014 213988 57261 103963 217351 56637 214150 69038 227743 13135 15894 19247 13819 14969 14968 66753 104709 67819 208154 14056 15170 116891 17454 20338 16569 319169 109270 50723 67075 105787 108079 20846 19079 54130 20848 108097 625328 78303 319188 15270 58205 16818 19082 80286 56716 624153 68292 23797 16430 382522 233833 53859 16451 21415 232440 13200 16570 13626 319149 72297 22628 320207 16478 16842 22612 11651 11652 12483 22324 15077 269523 66310 18710 140858 97064 18566 230979 52615 26410 19646 213464 14360 12988 11910 16568 214162 13001 13000 100039026 17869 245688 20747 12500 22601 12501 12502 15251 17096 23808 67731 12504 18109 244373 18005 17444 78757 228775 53598 60533 76580 108099 16362 30955 18708 18709 18479 12477 18706 18607 74769 18707 13038 66357 12487 12519 380711 12524 13039 20469 21414 21416 231051 18481 12702 16594 668303 16579 232943 13036 13034 19348 229445 56464 71819 226977 16593 16551 110033 280408 16149 209737 20201 74764 20202 15002 15001 64291 16768 15000 14998 67923 106052 242960 20343 30838 13052 83490 77647 270152 58217 30050 50762 15896 170786 22319 50754 19211 19349 232801 30925 217304 26904 14130 217306 16572 100043861 213980 16573 16641 16643 16412 232790 68628 71326 50928 52685 75345 21947 57781 17086 50789 231805 170741 84544 30839 243958 243864 54215 75863 629970 100038830 52855 328833 83382 246746 20612 319352 27007 54698 18146 12480 20400 12525 225825 224840 17470 140497 23900 94212 16419 57743 17534 21354 21356 13033 21355 93836 53421 20909 100043039 246278 66212 12343 12345 12340 16571 16410 67300 13429 12757 71745 14026 74947 17973 12317 20743 103967 66105 22323 12330 80751 19025 66313 12143 22320 11840 13430 21762 22123 12675 108723 19179 19181 19182 23996 19184 75788 18033 26440 19166 18035 19167 18036 26441 18037 16822 26442 75669 22637 69077 16797 66997 630146 23997 23880 12234 16428 56436 17463 57296 20422 26445 26446 225326 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 19696 22063 12042 66413 26965 667035 22190 18751 240354 59029 26409 67089 103583 70247 117589 78541 69299 218215 16408 94090 233902 69116 208650 73998 50760 20821 235320 242521 209239 74492 75234 66799 16401 72194 67845 15204 69706 235439 13040 15007 57751 19141 12010 140630 56508 11768 94091 13030 223864 11769 217194 12478 108012 16924 12520 11764 22019 226541 11765 65257 11767 104184 252903 19820 78913 242785 56791 68729 16912 69010 19171 211949 66743 233040 231672 18744 50492 224826 231863 101358 12449 224023 16913 109161 83814 22193 71538 19186 76375 19188 67455 100041766 14794 216150 217217 71999 93765 269529 66589 83962 18761 230654 22034 635668 19395 240028 66515 269514 68652 78889 69162 68431 230904 28105 71865 380928 20333 50868 207215 22200 627648 22631 207304 75717 70294 13032 67921 100041484 22192 66663 217232 142688 56317 243574 59008 321006 268291 66156 209200 216080 74646 69957 448987 17222 22346 56736 68612 228003 52563 12703 22194 212919 71393 68999 54484 52206 20439 100039535 218793 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 12571 12567 12578 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs 11684 11687 19225 11689 PHOSPHO-PLA2 PATHWAY%REACTOME%R-HSA-111995.3 phospho-PLA2 pathway 18783 26413 DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME%R-HSA-3656234.4 Defective HEXA causes GM2-gangliosidosis 1 15211 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants 18595 TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P 21351 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373076 Class A 1 (Rhodopsin-like receptors) 17202 17201 22094 12640 140498 212108 19773 242093 381489 239336 16336 23919 14419 12772 12774 12768 80901 14747 84112 20607 59289 12776 12775 12458 12773 12771 170458 18386 18389 14539 23925 19214 243270 239283 19222 14427 19217 18166 19218 19219 18167 18168 14294 12802 14293 12801 14309 21390 12765 227288 14308 56838 57811 17773 244701 19156 20605 19065 11550 20606 19064 11548 211578 11549 80885 272031 12145 20609 20608 14428 13051 227289 75769 217212 208990 216152 22439 11820 20132 140795 57349 17171 30878 623503 107522 17329 20290 11554 17200 11555 18155 11556 55985 15560 20303 109648 15559 20304 12057 15558 20306 213788 20296 15557 20292 13492 20302 382348 57385 13491 20295 13490 20297 13489 100039973 13488 74191 111174 100038965 215855 20299 503558 13610 215854 56066 12672 20311 12671 20312 15552 20300 15466 11539 15551 11540 15550 18610 243764 18619 12669 229791 15465 235044 99296 11542 18241 252837 209512 66102 15566 13611 15565 22095 15563 330122 15562 225192 94226 20310 14825 353344 14429 14764 13603 11609 23796 12777 226278 12766 226304 321019 12778 381073 110168 75805 436440 76854 12769 64095 15199 230857 14763 54199 70839 12267 171469 16866 16867 227326 14739 12854 13609 13349 16952 15945 70086 20315 11541 58861 12767 53978 22044 22045 57260 233571 235036 13617 30044 14715 14714 13615 18441 246691 18442 14745 16963 16995 208188 229214 56183 56696 58182 19204 104443 224065 19216 19220 319239 14289 238377 14744 225642 56744 14829 67168 21333 11606 11607 12061 12062 216749 21338 14064 20293 65086 14063 14062 14061 21337 23832 319197 21334 21336 12424 12425 12426 217369 227717 14065 381810 107221 280287 24111 574402 78134 100043254 237362 385643 433292 246313 233079 233080 233081 50501 67405 18216 54615 12209 78826 114229 15171 110312 18217 387285 230777 11551 14767 11552 68039 11553 18101 18429 11998 18430 54140 26361 12000 18387 18390 212541 20210 15139 12266 319430 12273 20604 207911 13616 13614 18976 17199 13618 17203 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes 18127 17969 18173 13058 76113 13057 242341 68775 18126 17970 17523 19354 76252 17972 11972 108664 66290 11964 110935 18125 11966 100039636 66335 11973 11974 74915 338375 21871 73834 114143 66237 11975 74096 27060 140494 66144 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9754678.3 SARS-CoV-2 modulates host translation machinery 16785 57294 107686 384091 666609 216766 621705 20595 66603 53975 276919 20641 667035 20638 69731 432803 67332 27207 67097 670832 100039316 633683 20044 27050 667279 20085 668144 20084 382492 20055 75617 20115 27370 629957 76846 20102 100040298 20103 668668 667739 66481 225058 100038875 267019 67941 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME%R-HSA-9931512.1 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 12914 214162 12753 11865 EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%3928664 Ephrin signaling 54126 13848 13846 13845 270190 216963 18481 13643 13642 13641 19353 53378 13844 17974 224105 18479 14360 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation 18295 16545 244757 116847 17022 75612 50917 14264 70893 15212 15211 27047 12091 MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 96%9022927 MECP2 regulates transcription of genes involved in GABA signaling 14415 14417 DEFECTIVE CUBN CAUSES MGA1%REACTOME DATABASE ID RELEASE 96%3359463 Defective CUBN causes MGA1 93835 14603 65969 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-HSA-8878159.4 Transcriptional regulation by RUNX3 56436 20750 17463 16449 57296 21415 20422 26445 12387 26446 12575 11906 19172 19173 19175 19177 20779 18128 16842 26443 12443 26444 270118 19170 66413 667035 97064 22190 59029 67089 14219 70247 16408 17869 22601 22059 17127 208727 17128 16401 21679 66313 21676 21678 103806 14312 21677 328572 12400 21414 17246 21416 333639 12399 12578 12914 14534 18519 21762 22123 15205 19179 19181 21803 19182 23996 56484 19664 19184 75788 26440 16653 19166 19167 26441 26442 69077 12125 66997 23997 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190239 FGFR3 ligand binding and activation 14172 80857 14425 14180 80903 64654 14175 14173 14164 ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism 67103 13479 320997 245533 13120 11690 631304 11687 13118 72054 17250 208285 21391 19223 13124 19225 11689 13850 18783 17164 54486 16993 15446 17001 11686 23801 14775 625249 72303 107141 13077 19215 13076 13110 71519 106648 105349 14776 96979 100040843 13078 19224 11684 77219 12408 14073 18979 100043508 330260 269823 14598 11688 319446 64292 23887 66469 26457 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%1250196 SHC1 events in ERBB2 signaling 13866 13649 18753 18183 83961 100042150 12223 18176 20662 13874 15461 15200 211323 19248 13645 18754 18750 20416 MAPLE SYRUP URINE DISEASE%REACTOME%R-HSA-9865114.1 Maple Syrup Urine Disease 12040 243382 13171 13382 12039 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 96%141334 PAOs oxidise polyamines to amines 212503 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 96%5579014 Defective CYP27B1 causes VDDR1A 13115 SIGNALING BY EGFRVIII IN CANCER%REACTOME DATABASE ID RELEASE 96%5637812 Signaling by EGFRvIII in Cancer 12539 13649 12402 18176 14388 20662 15461 18803 13645 18708 18706 20416 15519 MRNA CAPPING%REACTOME%R-HSA-72086.5 mRNA Capping 68092 433702 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters 94249 76376 226999 236794 67547 331004 77031 236727 109552 105243 277973 110895 226781 20544 18173 338365 22784 170756 230810 18174 214111 53945 110891 106957 22782 98396 238384 213053 214922 640703 20541 227059 72027 106947 69048 110893 20529 15203 317750 12870 30791 14977 239436 72002 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%210990 PECAM1 interactions 16416 15170 18613 18803 16818 19247 16331 17096 14360 22612 16410 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter 21374 67065 71752 74414 233863 66420 72308 69833 78929 245841 544971 70239 269252 26939 67486 70408 20018 69870 70428 67371 17749 218832 100043714 67005 20016 98488 12909 G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK 14708 14706 14702 14704 14696 14695 14693 64337 14709 14697 14701 12229 14710 14699 66066 14700 14688 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020591 Interleukin-12 signaling 16451 66902 18453 68981 54721 16153 19188 56044 11840 12631 20955 50926 667310 66162 18569 12798 18738 268373 11632 20849 12340 18826 53379 17319 18788 12306 16162 98758 16161 16160 15526 16159 20656 21351 14873 215449 21454 16906 667618 224105 17698 12346 16452 15978 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters 55961 243755 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 96%9837999 Mitochondrial protein degradation 18293 636544 17991 66885 381760 14194 66948 69597 20917 66865 20845 13171 13382 68514 22272 624814 27377 17708 18747 17709 66494 69029 67003 234847 66904 15510 51798 171210 227197 67184 230075 64704 74142 14661 11655 14151 71147 56454 108037 21780 53895 64657 270166 433923 11740 69076 72535 17721 17722 17716 11669 17717 52815 56322 433806 15108 74143 227112 107029 99138 68646 13177 17995 67013 15107 11957 12858 78330 30059 68263 228026 11947 12857 75398 11949 11429 56282 67041 17705 67834 11946 269951 15526 110446 18597 15360 30056 71911 432676 381314 118451 11847 12974 226153 17448 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 96%198765 Signalling to ERK5 23938 23939 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle 52717 99152 56299 668450 29870 17187 12534 217653 20892 233532 100038822 70645 66311 70620 66578 26416 26413 240087 12545 59046 244329 59021 382030 67121 19094 56205 21664 52432 76044 78658 54401 71175 74549 66352 67181 52683 70231 16452 15516 328572 109145 17216 272551 17215 17217 17218 17219 103573 17220 78833 12544 69270 16906 22627 63955 22390 99412 72568 77805 12530 231506 12531 629959 54124 12532 20459 75660 23834 71988 208084 72171 214987 214901 20174 68964 72107 108689 56438 69535 18969 18968 19075 19076 66371 68953 93762 75608 14235 208092 66700 19088 223697 105513 12575 22589 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 21973 56371 27401 13163 16881 12448 12577 12576 108911 73470 16563 75786 18747 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 59125 218914 59126 12235 217718 67037 20842 68097 16319 213389 19052 28113 73804 19053 101185 51792 20877 381318 24061 52696 26886 66934 18221 445007 19357 226849 225849 17248 72155 26931 21770 26932 70385 12428 57294 17246 56455 226747 17120 26951 100710 57321 108000 229841 12237 12617 107995 72415 83815 12615 66570 319152 244495 208628 76707 21749 67139 497652 68014 21750 83431 13589 100043858 67849 12580 69912 625534 12579 13006 12578 18472 67733 103468 66468 76464 66442 67629 235661 56430 12427 234865 56150 12442 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 71521 13426 52504 17931 13424 228421 20843 17350 15366 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 66671 17749 100043714 17420 12572 15267 319168 319167 100986 15512 319186 319178 29813 319183 59092 319182 26374 50883 228829 319190 230376 319176 69654 71648 17274 319181 75296 56637 219072 225659 76478 22367 71955 78177 64383 224640 319169 319965 105988 28135 50850 214444 100042651 76816 54130 625328 56739 78303 140557 319188 50878 15270 20962 381644 74075 320558 64009 319565 71846 18750 624153 66654 20957 23797 75459 77053 382522 20873 68121 232440 78887 78798 319149 22628 225745 231123 11651 11652 15077 74360 238799 18536 66296 214552 21752 19646 18541 116733 13001 13000 100039026 17869 245688 71909 237222 94244 55948 30939 17096 17997 13548 22171 21877 13361 18005 73738 68475 53598 208518 100088 236266 12009 99100 103733 22154 98386 74470 104318 101565 16328 259279 14211 83922 171567 51885 68298 19348 215387 26370 76789 72083 71819 70099 101706 233276 103768 74237 22147 22151 19650 19651 17865 27373 22143 93687 208583 268930 53857 22152 227613 72119 22153 18148 216853 22142 22146 67951 100039786 73710 13726 22145 22059 71782 545486 238463 170762 108989 231042 227699 223921 227720 380664 269113 66679 18141 23825 107939 69482 71805 16475 54563 19069 70699 67141 72787 64899 18226 218210 50793 18392 72590 18393 30949 66634 14245 77011 26428 19046 72486 26429 12537 56452 77744 64898 71978 20135 15519 11350 16211 19384 219103 229776 56505 50496 13559 104394 21762 22123 19179 19181 19182 67956 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 27214 17463 67177 57296 20422 26445 14156 245474 26446 57441 19172 70024 19173 19175 19177 21402 26443 66181 26444 19170 66413 26965 68147 667035 22190 18751 52530 59029 107823 13404 67089 68251 26972 103583 20184 19183 70247 217716 269582 76915 55993 70681 17687 70238 27223 12795 107976 210766 59004 22196 15204 671392 19360 69745 17535 21975 27354 12021 60530 81601 327762 269400 59001 19361 114714 22427 19687 19718 69263 231863 15574 11920 66979 12189 12190 235610 231724 237911 19355 225182 93765 26909 18538 235559 19324 12144 105522 381306 68275 106344 72151 18971 68240 67857 18972 19891 18973 18974 74498 22631 19367 52036 19356 22629 67967 20878 12649 217232 56317 59008 18817 66156 433759 216080 56041 69957 448987 17222 75430 68612 52563 22194 76308 68999 52206 100039535 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) 20526 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 96%162599 Late Phase of HIV Life Cycle 18108 107305 72543 194309 52348 116733 73711 22088 67123 330192 76959 66201 19386 20479 66914 19384 100088 19385 18107 445007 270627 68092 228980 319944 21374 103573 433702 20922 20833 216185 108143 18550 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 69912 21343 209361 226182 12454 229906 103468 235459 24074 268373 83602 58202 68153 74197 67923 234865 27224 27632 24116 12455 72949 59015 13716 69736 63856 110379 68705 98053 667035 13871 22190 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 66371 14884 68953 75608 18571 170762 108989 231042 227699 208092 223921 227720 66700 269113 66679 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 83814 105513 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855170 IPs transport between nucleus and cytosol 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 96%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA 78920 13382 209692 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69273 Cyclin A B1 B2 associated events during G2 M transition 12532 12534 12428 217653 268930 100038822 103573 12566 72415 72590 30949 77011 56371 72486 77744 66671 12427 17420 73699 12572 12442 71978 19052 19053 18817 51792 14235 22390 12530 12531 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013425 RHOT1 GTPase cycle 59040 67095 70827 229877 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation 94111 20750 13406 30060 15464 11704 19089 71421 217847 77583 105348 80752 16852 18220 11816 15160 66853 20856 381677 66848 338366 83554 11576 12558 66557 98170 17182 14314 16425 232146 12155 76453 74761 15529 100037258 14161 71853 29817 99571 22393 12159 216197 11806 238055 16193 385643 14734 19123 12870 22041 11820 14456 11487 64654 11905 13010 17304 18619 56453 12266 625018 16777 21923 16779 226519 14268 16709 14118 382014 22027 12321 100102 17283 20255 18453 16009 16006 66113 104009 11657 20703 11625 11807 14067 21857 269181 66940 208659 13003 13602 16007 75396 16011 16010 246228 12977 13801 11804 12653 11698 20254 56047 268977 19672 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism 13479 16922 12908 68801 17117 67528 21835 74114 110959 14081 56185 80911 13850 111175 93732 97212 20280 11363 231086 171210 17164 56794 108099 54486 16993 15446 11686 23801 14775 625249 14104 72303 107141 13077 19215 13076 70316 13110 14776 96979 20524 11409 93747 12896 15107 12895 20216 68041 18559 19224 66198 264895 56473 77219 76267 12408 14073 66834 18979 57279 330260 74147 269823 171282 70025 11666 26458 71985 15488 52538 113868 72482 170789 11688 26378 78245 64292 102632 66469 26457 56360 171281 67103 74156 320997 245533 13120 13167 11690 223722 631304 329910 11687 13118 72054 17250 208285 74159 21391 19223 13124 20249 67131 170439 107476 19225 11689 20181 110821 66904 17850 73724 109136 18783 12894 75778 17001 19063 257633 433256 83603 74522 54397 50790 15487 328845 74205 57874 71519 14979 106648 30963 105349 104112 100040843 11370 106529 13078 54325 20520 66775 94180 74121 12686 216739 11364 74559 67460 234309 13177 243078 70757 56348 99035 26568 54326 11684 100043508 26922 108079 108097 14598 19015 319446 23887 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702620 quizartinib-resistant FLT3 mutants 14255 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME%R-HSA-3560783.4 Defective B4GALT7 causes EDS, progeroid type 15529 11603 23888 20971 12111 121021 13004 20969 15530 14734 103978 71951 29873 20970 13003 218271 14735 14733 12032 13179 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-HSA-176408.6 Regulation of APC C activators between G1 S and early anaphase 12234 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19177 21402 26443 26444 12566 19170 66413 26965 56371 667035 22190 59029 67089 70247 12428 12237 67141 107995 12427 56150 21762 22123 19179 19181 19182 217232 23996 56317 12236 19184 59008 18817 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 96%445989 TAK1-dependent IKK and NF-kappa-B activation 22030 19697 16150 18034 16151 192656 16179 434174 71481 667035 211550 22190 66513 93765 20203 66589 26409 20210 24110 22034 257632 66724 68652 80750 223664 107607 69721 270151 11596 67454 22059 71966 12675 108960 59025 18033 18035 18036 11820 12370 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 96%8964572 Lipid particle organization 243168 14311 69573 12683 68680 228859 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 96%399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 53623 14799 17246 243547 14802 238276 18693 11771 12322 12323 108058 12325 18751 14800 54377 21912 13385 74053 18195 13383 12300 54376 18752 81905 17920 18750 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression 233833 20807 19712 236511 17454 225872 14815 56461 213988 217351 214150 76850 239528 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 96%5676934 Protein repair 22166 320183 27361 76467 110265 18537 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint 12532 12534 22628 70620 107823 68251 20184 240087 70681 70238 100039786 27223 107976 210766 54401 55948 22059 59004 15204 19360 17535 21975 319186 27354 12021 319178 319183 319182 81601 50883 327762 12428 319190 22427 19718 69263 15574 319181 11920 12189 235610 319152 231724 237911 19355 225182 93765 26909 235559 12144 68275 106344 72151 68240 19891 12427 22631 19367 22629 19356 12649 78303 319188 15270 22627 22390 382522 DEFECTIVE CBLIF CAUSES IFD%REACTOME DATABASE ID RELEASE 96%3359457 Defective CBLIF causes IFD 14603 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate 68275 18969 18968 18971 327762 68240 18972 14156 19075 19076 19891 67967 69745 18538 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%9623433 LXRs regulate gene expression to control bile acid homeostasis 22260 20181 20602 20182 22236 17977 16204 20185 22259 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380259 Loss of Nlp from mitotic centrosomes 20873 68121 12534 78887 22628 225745 231123 227613 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 83922 75296 26370 76707 219072 13589 225659 18472 76478 78177 28135 214444 76816 54130 18817 381644 13427 22627 13424 27373 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 96%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 22632 13866 70472 13982 16590 12640 13649 22339 21802 21420 21419 21418 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein 93687 15469 22196 20817 214424 20815 328417 606496 67287 80285 52552 56637 671535 547253 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars 108652 22232 229782 228368 58246 24060 242585 70484 73836 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes 75766 78284 270669 12913 77128 26427 208647 208677 56453 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 96%8949664 Processing of SMDT1 78506 215999 69029 234847 73078 69597 66865 381038 66815 68115 68514 12034 66592 18673 27377 216001 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma 15200 18803 11839 13649 21802 13645 12223 71920 13874 PYROPTOSIS%REACTOME%R-HSA-5620971.6 Pyroptosis 670717 16173 16363 69146 22059 66371 12018 14939 50701 22061 68953 12367 16176 105513 75608 16175 12362 12028 54722 434174 12363 16362 208092 66700 BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations 13479 17161 109731 110198 71522 207182 71670 56615 211666 66447 13075 244209 70484 69574 68021 11670 76263 22017 13849 20186 14863 237940 13123 104086 11754 13122 67758 107146 216558 109857 233799 233801 212503 18105 272428 435528 67247 66112 69065 75475 13885 14872 54486 17961 68252 94215 66054 72094 15516 14862 213012 14630 14865 394436 14866 394433 68312 22235 100042314 71773 14874 13087 100727 13116 14871 13107 436059 100559 14261 13115 68044 13106 231396 110115 68214 622127 394434 56050 11624 94284 18984 11622 552899 72303 223337 107141 17977 242585 13088 17960 13077 56448 13076 13114 74134 17978 72082 13110 13113 545817 14859 13070 14629 19224 66427 67768 108645 57344 67883 67674 238505 11720 109652 232087 210009 14873 14854 269378 18113 12846 320997 76507 13120 631304 13118 72054 208285 64385 21391 19223 13124 22021 13121 22022 55990 14262 117147 20181 104158 11668 102294 68165 14149 14148 58810 13082 13081 13072 60525 13079 72535 232174 11529 68738 546726 11522 26876 71519 11532 106648 11669 13909 100040843 13078 11863 11864 76491 11632 56362 319655 20859 242291 100043508 20860 23827 73671 29859 20887 18976 14598 319446 109754 22236 23887 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins 17002 16819 20201 20202 HCN CHANNELS%REACTOME DATABASE ID RELEASE 96%1296061 HCN channels 15165 15168 330953 15166 RAS GTPASE CYCLE MUTANTS%REACTOME%R-HSA-9649913.5 RAS GTPase cycle mutants 15461 16653 18176 PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-HSA-418360.3 Platelet calcium homeostasis 269717 11937 11938 53313 109305 109552 67972 11941 320707 381290 22065 22068 20866 110891 16438 16439 18438 640703 20541 110893 26946 16440 18436 228139 18440 94045 231602 18439 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 96%9674555 Signaling by CSF3 (G-CSF) 14389 16451 19823 12702 20851 20850 54721 20963 14784 66105 667035 100041766 22190 19247 20416 12986 67923 75717 17096 20846 20848 12985 16653 216080 15162 12703 16452 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases 12388 12387 15901 58194 20408 12402 56324 20779 15239 20404 17295 12389 20844 20405 13858 107746 14786 109880 12929 208994 26416 12928 19271 56044 64143 18754 18049 17999 216148 26413 26417 29857 20416 67588 327826 22325 107568 18211 109905 77480 19094 20418 102626 15925 19730 54401 116701 26415 26395 26396 57257 19762 18176 20662 19877 19769 15461 16416 17164 215449 19878 16480 16452 328572 12539 17395 13367 18552 18550 17260 18553 17261 242341 68775 15183 20185 76252 11972 108664 66290 54126 11909 640703 11964 110935 11966 100039636 66335 11973 11974 74915 15234 338375 21871 73834 14181 114143 72514 66237 11975 16542 54411 27060 12569 12568 50884 140494 83767 329165 66144 20459 105855 242687 19205 17969 76936 11308 13058 13057 108100 17970 101314 17972 12830 13433 11516 13385 12829 12828 15382 11517 12827 18595 12826 59013 19164 98758 19165 12841 100042305 208117 12840 59287 100039623 245026 12839 140580 16396 12835 12834 12833 12385 56424 16453 11771 11772 12028 71770 232910 11773 245880 114715 19342 114716 218397 18749 319939 217169 67299 76884 16186 19253 14255 229709 16438 16439 18747 19255 15507 16440 73699 110651 20112 19052 19053 51792 20732 15451 15235 19882 20733 21770 15904 211323 14402 14401 14400 23939 14394 14407 12064 14406 14812 14388 21844 18212 208869 57249 18205 107971 78405 18803 11839 13645 26362 19283 11487 11491 12562 17005 51789 68705 98053 66420 69833 67710 17258 245841 20203 69920 20022 20020 231329 20021 69241 17749 100043714 620393 100040260 19242 101568 235584 67603 319520 72349 14281 224105 13654 75778 14282 56717 13653 19353 14256 227743 19247 15170 109270 20846 20848 19341 17242 14257 16818 260302 56716 18750 23797 21990 56437 14066 17095 12570 15902 23938 17172 54152 18183 15903 83961 14283 100042150 211770 16478 76890 17936 17937 22612 11838 11651 11682 13656 11652 13655 22324 381677 19303 18710 18791 14360 54607 12988 16370 16002 16000 17869 13649 21802 22601 15251 17096 14580 18109 17444 78757 228775 17122 21825 60533 231821 18708 71785 18709 18479 21827 16765 18706 21828 18607 214425 74769 12991 18127 27371 230126 18481 24064 68092 17346 54426 433702 16477 80707 58202 16001 18596 18213 21682 18762 16923 11848 17228 19273 71520 14159 14158 23921 73086 107932 11540 74334 19712 16412 140579 330662 19246 20698 20430 59079 24063 19272 16206 239463 94212 20851 20850 14784 19248 13033 13866 14425 16410 14083 21814 21826 67903 17974 224116 18187 67300 20315 13429 12757 20750 17973 20393 18186 84092 11816 71436 103967 15519 56705 399558 396184 19268 19280 12223 71920 13874 13712 15200 19229 14254 13430 80903 384783 75669 14186 14165 81897 14389 16367 14172 80857 18576 14170 16334 225326 14180 14178 14177 67112 64654 14175 14174 14173 14164 83379 16398 667035 16400 22190 18751 18654 21406 13982 19277 18753 16775 16776 16777 16779 16780 226519 16782 16772 23928 11489 16773 16774 18667 227290 18591 20807 14783 16337 12927 20852 13854 12142 68652 11845 14205 20111 13859 75717 18815 20466 12649 17179 20692 433759 16590 22341 93686 22339 77411 22340 21843 21841 12703 15182 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET 58194 20408 12402 56324 20779 84092 15239 20404 17295 20844 20405 13858 107746 16398 12929 16400 667035 22190 12928 19271 74334 19255 56705 109905 16412 16775 16776 16777 16779 18176 16780 20662 226519 15461 16782 16772 23928 16773 16774 215449 19246 18708 20732 15451 18706 20733 16206 54426 19353 19247 11845 19342 14388 15234 14083 20848 19341 224116 260302 319939 217169 67299 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 96%9028731 Activated NTRK2 signals through FRS2 and FRS3 18212 327826 15461 107971 78405 19247 12064 18176 20662 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 56389 83762 15368 71446 13726 224727 56495 30960 28146 67604 27643 19122 22318 20907 11820 12328 52551 100043039 66212 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174411.6 Polymerase switching on the C-strand of the telomere 214987 214901 68964 72107 108689 19687 57321 69535 19718 69263 21749 497652 21750 18538 18969 106344 18968 72151 18971 18972 19075 19076 67967 28113 101185 69745 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 12567 26443 12443 26444 19170 66413 56637 667035 22190 59029 67089 70247 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME%R-HSA-9918449.1 Defective visual phototransduction due to STRA6 loss of function 22139 20897 19662 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 96%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) 103988 ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 96%9914355 Isovaleric acidemia 56357 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9828642 Respiratory syncytial virus genome transcription 15481 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 96%187042 TRKA activation by NGF 18211 18049 DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 22021 14069 22022 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide 71934 12350 12352 230099 12353 12354 56078 76459 23831 12346 12349 12351 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9909438 3-Methylcrotonyl-CoA carboxylase deficiency 78038 72039 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 96%2408552 Methylation of MeSeH for excretion 21743 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME%R-HSA-2466712.4 Biosynthesis of A2E, implicated in retinal degradation 242864 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) 20537 DRUG ADME%REACTOME DATABASE ID RELEASE 96%9748784 Drug ADME 17250 71522 207182 22324 12780 15484 15483 12401 18102 76952 18103 229363 27416 239273 114304 16434 22436 22325 104158 214254 13340 269346 15452 22017 63959 100042069 14863 23917 14923 77337 57257 107146 233799 12038 233801 272428 435528 17961 94215 72094 66054 394436 76408 394433 71773 100727 100559 14871 436059 231396 13106 394434 94284 552899 223337 72303 107141 17960 56448 13114 19353 20518 20517 20519 18671 11657 19879 28250 75894 18950 26357 20501 11534 11486 12215 20859 18979 20860 28253 269823 71279 20887 109652 14598 22236 23887 18534 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-HSA-8951430.3 RUNX3 regulates WNT signaling 21415 17869 12387 21414 21416 12399 16842 12443 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.5 Loss of Function of SMAD2 3 in Cancer 21803 21812 21813 17126 17127 17128 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9603381 Activated NTRK3 signals through PI3K 16367 18213 18205 18708 20779 18706 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly 16782 12821 192897 18810 16774 16403 12476 16780 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 96%380615 Clearance of seratonin 17161 11669 15567 CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle 12896 20181 12895 108097 68041 19015 21835 12894 108099 20520 57279 108079 NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%8956320 Nucleotide biosynthesis 67054 14450 100042069 108147 23917 69719 11564 11566 231327 237823 22247 229363 11565 56749 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6793080 rRNA modification in the mitochondrion 72181 75619 227682 83485 94254 224481 66410 67390 217038 69821 71989 101122 68017 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME%R-HSA-5619108.3 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) 26569 SIGNALING BY FGFR2%REACTOME%R-HSA-5654738.4 Signaling by FGFR2 14172 80857 19205 14180 14178 12402 14177 76936 67112 64654 14175 14174 14173 14164 109880 68705 98053 667035 22190 66420 69833 67710 245841 69920 26413 20022 26417 327826 20020 231329 20021 69241 17749 100043714 15382 18176 59013 20662 98758 15461 19052 19053 51792 18708 18706 68092 24064 17346 433702 19247 14388 14181 107971 72514 18803 93686 77411 80903 21843 21841 14165 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%419408 Lysosphingolipid and LPA receptors 13611 14745 94226 65086 272031 14739 53978 75769 13610 13609 216152 381810 229791 235044 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 96%162791 Attachment of GPI anchor to uPAR 241062 329777 228812 78928 276846 14731 18793 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 96%5387390 Hh mutants abrogate ligand secretion 56436 17463 57296 20422 26445 26446 19172 19173 19175 226861 19177 26443 216440 26444 19170 269523 66413 667035 22190 59029 67089 70247 66753 16147 116891 20338 74126 21762 22123 20423 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 13363 66997 23997 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%937061 TRIF (TICAM1)-mediated TLR4 signaling 66105 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 11909 26419 12675 16476 18033 18035 18036 11820 12234 56480 54131 19697 21402 73086 16150 16151 192656 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 80750 223664 107607 69721 231130 270151 11596 22059 67454 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 19766 11797 56532 22030 12475 22031 56489 225471 11796 106759 21353 18034 71648 54123 434174 100041766 14082 66513 93765 66589 19247 22034 66724 68652 20111 216080 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 96%163210 Formation of ATP by chemiosmotic coupling 66477 11958 11957 11947 11949 68055 17705 11946 66043 11950 100041835 100039108 432676 228033 227112 57423 SIGNALING BY GSK3BETA MUTANTS%REACTOME%R-HSA-5339716.5 Signaling by GSK3beta mutants 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME%R-HSA-9032845.3 Activated NTRK2 signals through CDK5 19353 18212 12569 12568 12064 21844 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170984 ARMS-mediated activation 18211 109905 77480 109880 12928 54401 18049 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-HSA-947581.2 Molybdenum cofactor biosynthesis 69372 268566 68591 17434 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing 54188 54196 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD 11720 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-HSA-174184.3 Cdc20:Phospho-APC C mediated degradation of Cyclin A 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 12428 12237 107995 12427 56150 21762 22123 19179 19181 19182 217232 23996 56317 12236 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 96%5263617 Metabolism of ingested MeSeO2H into MeSeH 50493 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 96%8983711 OAS antiviral response 246727 231655 24015 230073 24014 192176 23960 211948 246728 VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways 56208 66383 67443 74153 78610 22201 74244 12389 100042069 23917 171210 19877 15381 231380 22352 19298 19878 70233 67224 378425 19655 218978 218035 15516 73075 66999 269061 70616 66892 68598 67959 12609 17395 100040603 232989 269338 107701 67480 66286 72047 74326 67500 56298 17755 18452 16172 75956 18550 66861 56031 80744 69550 218490 22365 66101 19035 66270 70225 69019 18451 13684 80743 68879 28185 320632 208643 67418 212880 66585 108098 74351 83486 74370 216705 66877 56529 23983 18521 83701 12695 57905 224912 68479 56217 77573 13690 15569 209416 66172 20222 320452 67838 60321 192191 24088 21897 78334 17713 257630 66070 23845 66810 319322 12282 20683 233726 66397 19205 27967 20933 76936 171095 12412 69608 15006 218811 71702 27061 99683 68981 20639 229279 235623 240095 667803 23881 101943 81898 67439 94315 20646 27041 381379 14991 192159 77371 23806 11993 20334 67219 170779 21899 20390 53317 15382 53379 56258 66371 59013 98758 11991 68953 217365 11834 75608 234852 12362 20168 15388 18571 15387 12785 15162 228545 12526 66055 140580 16396 208092 68816 81910 66700 230861 19766 76199 67197 56532 213539 22230 54633 67465 66624 56445 73158 69192 71732 234779 53902 14827 67285 236732 223697 67958 68183 105513 76479 20963 20624 66642 233405 12229 64685 68137 75062 77134 27366 228005 76687 13205 28000 13204 246728 76938 16171 233908 66125 11931 58861 11932 11933 66824 216799 56188 12322 12323 108058 12325 16881 11928 98660 232975 57780 59095 108017 15977 12048 107686 384091 666609 216766 621705 20595 66603 53975 192656 276919 20641 20638 69731 432803 67332 257632 625018 107607 108960 103534 57377 27801 228136 75965 70546 108687 269181 57437 217664 69035 107895 20446 20444 20442 20443 17308 17158 20440 67569 14376 20447 71164 53618 20448 227619 69940 19089 208884 107338 70625 68975 234959 94112 70208 21849 13649 55948 23942 56771 80509 22154 56310 26896 16834 216848 107932 18148 100039786 19712 229542 24127 67279 21349 99982 14228 13207 100043508 18854 59024 327987 192292 17127 17128 17192 69790 22608 21762 22123 12675 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 14156 26446 19172 19173 19175 19697 13682 19177 13681 21402 16150 26443 26444 16151 19170 66413 16179 667035 22190 59029 26409 67089 75613 70247 14815 22196 621893 16401 319162 319173 319163 170743 170744 264064 142980 317677 17195 12259 83814 72512 54123 22596 13211 14375 214763 216154 51813 15469 69792 67381 15182 12387 20602 58194 23989 234366 28077 54401 171285 20662 19014 16452 328572 17087 21372 11806 103573 81004 21898 18024 15183 20185 108664 12914 268373 14225 66899 22627 56480 54131 58203 56438 108138 319583 18453 16453 16177 11771 54721 11772 50724 60406 71770 13609 20847 15980 17060 15979 58799 12518 217864 15985 15975 94246 18391 100041953 110606 26554 71954 107392 14272 232910 238247 11773 15353 68219 98985 228410 54451 108062 110611 67337 83410 18789 51786 94230 74320 68188 19645 13163 15529 216965 23888 20971 234663 19047 19386 20969 68097 71951 20970 14735 445007 57294 56455 15530 103978 14733 69912 76246 214498 103468 66317 235661 235497 14734 234865 22083 59015 54624 69736 17069 110379 68032 17289 13427 14828 19128 276891 13426 217303 22174 13424 14456 26362 17533 100732 52898 12737 21872 68705 98053 13871 225913 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 11603 231329 20021 69241 66671 17749 100043714 101772 24018 17420 67897 12572 13872 20924 23894 14884 15267 102566 404545 319168 319167 224105 105722 382014 319186 319178 319183 319182 320091 319190 12475 22031 56489 56717 319176 233246 319181 19353 20014 57261 103963 243634 56637 69038 227743 13135 19247 116871 51810 116870 14056 15170 319169 109270 67075 20846 14423 214424 328417 78303 606496 319188 67287 80285 52552 16818 671535 547253 80286 56716 68292 19092 23797 16430 382522 16451 13200 13626 319149 18108 22628 11651 11652 22324 15077 269523 18566 52615 107305 72543 19646 27681 70160 14360 194309 52348 116733 73711 13001 22088 13000 67123 100039026 330192 28084 245688 76959 66201 20479 66914 17096 12504 18005 233870 78757 100088 12774 18708 19385 18107 18607 66357 12487 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 229906 235459 24074 83602 58202 68153 74197 67923 27224 71586 27632 230073 24116 66641 12455 71956 72949 228607 13716 217069 63856 20817 14609 20815 16001 13051 19345 271457 19344 93687 170786 16412 94176 170762 108989 231042 227699 223921 227720 269113 66679 18141 23825 107939 69482 71805 11739 433923 11740 54563 16646 19069 15361 70699 101739 72787 19045 18226 218210 19046 27207 67097 670832 231413 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 21803 20103 668668 667739 54188 67300 672214 12757 66481 225058 100038875 100038991 68028 100043000 67891 100043295 18458 622534 238217 74568 16785 17973 666669 100040021 67025 12767 100043391 668182 241053 12317 18186 432502 100038882 19989 76808 19899 100043184 19921 19934 100043755 11545 193740 12330 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 16211 100039592 16648 19106 100037258 100043876 100043893 100043423 100042986 20115 67281 54196 76846 13480 625646 100040298 68172 13481 100042740 19951 381686 16649 70572 19384 667618 100040970 267019 56040 67248 100040331 67941 68563 14104 50528 70008 171283 14061 13712 64340 11840 622469 225027 15481 67996 51796 71713 233073 20382 110809 20383 21681 12846 108014 192170 69207 19826 75669 81897 100040029 225326 16194 69116 15568 22370 15007 12010 11768 11769 108012 11764 107975 11765 11767 252903 12759 56791 66513 93765 66589 22034 66724 68652 50868 22200 22631 75717 22629 66663 433759 22346 319189 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases 11931 11932 11933 11937 11938 53313 56188 109552 67972 11941 320707 381290 12322 12323 108058 12325 11944 11945 11928 98660 69047 232975 11981 11977 57780 170759 59095 11979 108017 54670 74772 50771 319767 224079 50770 231287 268878 11980 67331 235574 66388 76295 72621 192113 50769 320940 54667 11982 640703 PACKAGING OF TELOMERE ENDS%REACTOME%R-HSA-171306.5 Packaging Of Telomere Ends 319178 319183 319182 232440 319190 319169 57321 319176 319181 28113 15267 78303 101185 319188 319152 319168 15270 21749 319167 497652 21750 624153 319186 382522 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%111465 Apoptotic cleavage of cellular proteins 12387 12550 20230 21873 13511 13510 27061 21872 12367 18772 109620 13512 227753 70415 18761 223255 56215 269582 14272 18753 12169 19877 12369 14083 14453 11518 13169 18810 12368 16906 22352 11789 12370 11797 20740 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism 227619 17161 13075 244209 15452 22017 13123 104086 21452 217214 11898 109900 207958 21825 227231 18408 18416 67824 11846 19300 93747 68421 109652 14854 20531 17200 18129 18131 18128 18132 12040 12041 13171 13382 12039 107476 14262 20390 93835 65969 232174 546726 71519 13078 108153 23794 30806 108154 16795 210417 271127 229595 208936 77739 381694 269959 14425 269328 230145 110119 100689 233744 235130 240322 54128 20357 16848 11504 20356 17829 27410 18636 100039649 15926 21826 12984 14598 140474 29873 12982 224116 13003 226866 110006 217734 17063 15586 18478 59048 23972 240913 223838 15212 99011 15211 237360 12032 330119 13179 14387 216725 15932 73732 12091 18295 13138 66548 11881 330267 15931 207596 12111 224697 121021 14385 56229 13004 353328 239337 68273 14595 77794 94192 279028 17022 75612 269941 108902 218271 14264 105193 20389 15529 23888 20971 14635 227697 74246 319625 20969 19025 50798 57357 14430 14583 13480 50917 16548 13481 71951 20970 75475 14735 52014 53412 14630 66789 394436 394433 19895 14043 68563 14042 67422 13115 110115 18010 15530 242585 13521 27419 103978 18563 14733 13070 53374 14629 13853 68401 14734 116847 117592 238505 11720 21351 210009 110446 269378 14377 320997 78038 243382 227095 20387 11992 72039 56357 21391 72136 667035 22190 232493 14936 74185 27357 11603 16545 67880 110821 66904 17850 109136 72157 68165 69983 14149 27029 14148 77697 109129 67096 226413 56773 72727 27047 56737 320438 208624 102580 230163 24070 208211 381903 13478 328370 13081 13072 13074 13079 20388 110948 52120 18950 11486 54219 11821 26363 57377 18976 217664 14603 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling 16193 16451 16880 12931 12402 16878 12702 20846 100042555 18414 16195 16156 20848 54721 218624 13019 12804 56708 12803 19247 16194 18413 16452 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 96%9706369 Negative regulation of FLT3 16923 20491 12402 11352 216233 14256 667035 22190 19271 14255 77799 54607 12988 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME%R-HSA-9820448.2 Developmental Cell Lineages of the Exocrine Pancreas 14178 16775 16776 16777 14175 16779 16780 14173 226519 14268 16782 16772 23928 16773 16774 22370 13645 14165 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-HSA-2162123.6 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 15446 19224 77219 12408 100043508 19215 21391 19223 13124 105349 96979 64292 54486 66469 19225 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins 11689 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death 12048 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS 100039649 140474 224116 269328 353328 17063 59048 94192 73732 17829 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%75953 RNA Polymerase II Transcription Initiation 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111457 Release of apoptotic factors from the mitochondria 670717 12028 54722 66593 69146 12018 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111446 Activation of BIM and translocation to mitochondria 26419 56455 12125 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism 11666 68801 54326 56473 76267 54325 12686 14081 DEFECTIVE MUT CAUSES MMAM%REACTOME%R-HSA-3359478.5 Defective MUT causes MMAM 17850 109136 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion 18796 18797 18795 240444 16334 238076 14675 19087 19084 238276 16514 14697 12671 14710 14699 66066 14700 20910 229709 16438 16439 20927 18747 14708 14706 109905 14672 12491 14704 14695 14652 14676 16440 16500 20526 14693 268345 29875 64337 14709 14682 14701 56508 223864 12288 12286 14702 12290 14696 56808 14526 12296 19088 12297 50790 74205 14678 14677 17118 53420 14688 12289 20525 224129 233081 11512 11514 18749 22318 11551 20614 11553 20907 18750 19085 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2142789 Ubiquinol biosynthesis 242642 76889 217707 230027 67914 56075 12850 71883 227683 52064 71365 67426 99138 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 22072 66473 100017 93835 17850 17250 54219 109136 68421 238505 65969 21452 14725 77697 210009 109129 67096 14603 19300 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome 20928 16514 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 96%1483148 Synthesis of PG 18806 110911 74451 104759 66461 18805 18807 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events 12326 19088 55984 19108 19087 19084 104110 12322 12323 108058 12325 432530 210044 104111 18747 100039592 640703 224129 18753 11512 11513 110355 11514 18575 11515 18574 18573 18749 207565 18752 18750 19085 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 96%5674400 Constitutive Signaling by AKT1 E17K in Cancer 22084 54601 12575 17246 109270 56458 12015 56717 12371 12675 15370 67605 11651 11652 56484 606496 78757 56637 58988 227743 56716 12576 23797 18607 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9937850 NuRD complex assembly 216848 14377 232440 319149 13445 269610 106795 107932 22780 22779 78266 228880 15077 52004 17191 233410 11819 22778 622675 70998 14121 19646 234366 245688 22196 23942 17192 15267 70802 101631 319168 73503 319167 229542 319186 319178 319183 319182 319190 319176 319181 116871 22026 116870 319169 625328 78303 319188 15270 433759 15182 624153 18534 382522 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 96%422475 Axon guidance 20437 58194 20779 20404 17295 18844 14786 223881 26413 26417 20416 327826 22325 20418 26395 26396 57257 18176 20662 19877 15461 16416 11465 21894 19878 15516 213498 110596 17395 11852 65254 319713 14587 14586 20358 19122 69632 19197 12517 69585 210801 14588 53972 114873 20346 19262 19264 216439 235611 20351 54126 12292 244058 208643 26757 19056 83433 18845 22253 11853 20349 140571 22177 18846 231148 22240 57764 623279 13508 76829 54712 12569 20361 12568 114255 18188 12933 110351 214968 11876 13449 13448 68799 226251 216963 56438 77579 71960 20354 20130 16885 16886 12830 13385 12829 12828 12827 53310 12826 13383 19164 19165 12841 100042305 208117 12840 59287 100039623 245026 12839 12835 12834 12833 67784 76709 53378 73178 11771 11772 71770 56443 22359 19699 13131 68089 67771 11867 56378 66713 18738 232910 74117 11773 218397 18749 13004 17909 18747 15529 110651 20112 14573 57294 14585 76707 14733 23939 18007 14812 14388 21844 18803 13835 76499 67071 11487 11603 227377 224105 19876 259302 223666 20563 14270 117600 19353 56637 19247 13848 13846 13845 270190 13842 13840 17390 13841 13839 13838 13837 13637 13636 13643 13642 13641 13640 13639 13638 18750 14810 22612 18710 17886 14360 13001 67268 13000 100039026 13649 17096 18708 18709 18479 18706 12288 74769 18707 18481 107449 68092 107448 433702 67923 11848 14159 73086 11461 70584 19713 16412 545156 16443 330662 243743 58226 12291 13836 239556 67938 17904 223435 232906 17880 27207 67097 670832 633683 13866 20044 27050 667279 20085 668144 12289 20084 67186 382492 20055 75617 27370 18222 65019 16410 16571 20356 629957 14083 21367 20102 53870 268721 24046 20103 11352 13844 668668 14853 16728 667739 17974 12661 16825 16392 18187 67300 20315 13429 672214 170822 13193 12757 54003 19684 66481 71745 12934 225058 17925 16536 100038875 18208 17698 100038991 225363 110862 68028 14026 104099 100043000 17690 20739 67891 18458 20740 100043295 13138 235281 622534 14852 56613 238217 214230 74947 17973 20266 16785 16870 20265 666669 16871 12805 100040021 12767 11733 67025 268902 11735 100043391 326622 14432 668182 13176 640524 241053 18186 20742 16876 20741 432502 19087 319504 238276 20743 19989 20663 26394 76808 67252 20271 19899 12331 399548 100043184 241656 20272 19921 71436 20274 19934 18643 20273 100043755 18645 103967 22323 11658 16872 110876 67031 53321 319195 20564 20269 100043209 20562 72821 68193 15399 110880 621100 22350 19941 17967 665189 269116 666899 71653 100042670 80297 15519 20264 100039316 213119 11350 22121 56705 58234 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 20450 67941 20452 12295 12296 12297 12298 74325 15481 192160 13430 21762 22123 60365 19179 19181 19182 23996 19184 68134 26440 19166 19167 26441 192170 384783 26442 19826 69077 66997 23997 66441 14389 56436 17149 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 22063 109700 66413 22065 16398 22067 667035 22066 22190 22068 59029 67089 70247 26946 16777 226519 16399 16772 16402 14783 18761 12631 20111 18717 20439 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors 18796 18797 14708 14706 14702 18795 14704 14696 14807 14695 14693 64337 14709 14697 14701 14710 14699 66066 14700 14688 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases 545260 11881 58911 11883 271970 67902 74008 77041 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME%R-HSA-9662001.3 Defective factor VIII causes hemophilia A 22021 14069 14058 14071 22022 14061 22371 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 12021 81601 327762 20422 19361 114714 22427 19718 69263 15574 11920 12189 12190 235610 231724 237911 19355 57434 225182 26909 235559 12144 68275 106344 72151 68240 233826 19891 19367 19356 19362 19360 17535 21975 19363 19364 27354 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 96%71240 Tryptophan catabolism 107766 17254 15930 20539 70789 229905 56720 71562 234967 23923 70266 98256 209176 266645 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME%R-HSA-9617629.2 Regulation of FOXO transcriptional activity by acetylation 12914 328572 56484 54601 22166 56338 64384 56458 18519 93759 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling 21814 67903 14173 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.3 Loss of Function of TGFBR1 in Cancer 21803 21812 21813 17126 14225 17127 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters 20515 20504 20516 20505 142681 20531 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen 14723 14724 54368 14729 22371 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 96%3595177 Defective CHSY1 causes TPBS 269941 12111 29873 121021 13003 13004 12032 13179 DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER 59001 19687 19718 56438 69263 66979 11545 13871 68058 667035 22190 18538 14885 209357 66467 11546 13870 68275 106344 72151 18971 68240 18972 22590 19891 107986 18973 18974 22592 13872 50505 23894 14884 67967 27015 99375 69745 72584 13194 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%77387 Insulin receptor recycling 16334 16337 242341 68775 13033 76252 11972 108664 66290 11964 110935 15925 11966 100039636 66335 11973 11974 74915 338375 21871 19268 73834 114143 66237 11975 19246 54411 27060 140494 66144 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 11910 100039316 22121 27103 100043876 100043893 100043423 100042986 20115 67281 16210 76846 625646 100040298 231659 68172 100042740 19951 228775 13665 667618 67204 100040970 267019 56040 26905 67248 100040331 67941 27053 57294 11911 12611 27207 67097 670832 633683 20044 27050 11909 667279 20085 668144 20084 67186 382492 20055 12608 75617 13198 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 INTERLEUKIN-1 SIGNALING%REACTOME%R-HSA-9020702.4 Interleukin-1 signaling 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 56438 16150 26443 26444 16151 19170 192656 17874 66413 16179 26965 71481 667035 211550 22190 59029 20203 26410 26409 20210 67089 24110 103583 257632 70247 266632 80750 223664 107607 69721 73914 231130 93834 270151 11596 22059 16181 26395 67454 240518 71966 108960 59025 16178 16176 12370 22030 67245 26399 18034 26398 16177 16175 18412 434174 26406 66513 93765 66589 22034 66724 68652 21762 22123 12675 19179 19181 19182 54473 23996 19184 18033 26440 19166 18035 19167 18036 26441 11820 26442 69077 66997 23997 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 19247 14388 15234 17295 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%9013957 TLR3-mediated TICAM1-dependent programmed cell death 56532 14082 106759 12370 142980 19766 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME%R-HSA-9723905.2 Loss of function of TP53 in cancer due to loss of tetramerization ability 22059 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 11720 269378 18113 12411 50880 140483 14711 107869 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 96%114516 Disinhibition of SNARE formation 18752 20912 18751 18750 20909 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction 65107 67861 18108 12057 107477 14913 11816 665270 245650 14685 20215 12788 214111 212541 14699 19892 22139 239393 11304 75624 15529 11603 23888 20971 70061 24013 20969 56307 69060 77337 109791 102294 83702 19662 71951 20970 19660 77974 19661 243923 14735 19659 18107 235033 19771 19674 14919 68453 20148 67442 14539 15530 11806 98711 238055 19682 16956 20897 103978 216454 63857 17252 55938 241452 73582 105349 14733 18761 11807 11808 14688 110606 640703 14272 79235 170752 16835 14734 11813 11814 245532 237178 14725 15485 27400 16971 225600 17921 18750 18587 18588 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis 242669 75986 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling 15461 15200 11839 13649 21802 13645 12223 18176 71920 20662 13874 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-HSA-446193.3 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 20448 15275 50935 192156 67311 225742 236082 107652 26938 20451 380959 19703 245847 227697 20445 20449 54342 19025 50798 54613 66174 57357 50877 56174 14583 13480 14584 234730 13481 22122 241230 207958 75540 228368 66248 24060 240119 218138 20454 109785 52014 12764 56737 20450 320438 66789 57170 208624 69064 102580 94181 24070 74091 208211 68563 381903 67422 13478 20452 328370 18010 241159 23956 235504 110119 69080 331026 29858 54128 20446 20444 20442 20443 20440 12091 20447 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 96%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA 622534 238217 75452 16785 77987 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 66105 667035 22190 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 213753 57294 100041766 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 216080 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 96%400206 Regulation of lipid metabolism by PPARalpha 20602 23989 59024 18631 327987 70625 68975 14081 234959 94112 28077 70208 12491 20182 20186 171285 13122 11520 56771 50493 228775 80509 67224 19014 229003 11655 11865 66999 328572 11606 394434 21372 11624 109151 11622 11806 17977 73690 19017 18143 13076 17436 17978 59035 81004 66993 24001 69790 56310 12753 26896 15183 20185 217166 107765 12896 12914 56406 108098 76267 14200 18670 15360 66172 170826 192191 14373 26457 78334 94185 14137 100040592 20683 195733 18044 20933 18045 18046 20788 75613 381379 17764 22260 20181 67219 19013 19883 26379 19016 12894 18181 264064 19731 67544 230753 76199 67279 57875 22259 11303 66113 100040843 11807 11364 11863 11864 17979 216154 51813 14080 20859 69792 20466 67381 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 231863 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 21762 22123 20878 19179 19181 19182 23996 19184 26440 19166 448987 19167 26441 26442 69077 66997 23997 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex 66923 67155 26992 20586 20588 20587 56456 68094 83796 66993 83797 57376 12055 12054 11461 77045 72057 77044 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.3 Defective factor IX causes thrombophilia 14069 14058 14071 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 30939 18005 12428 12237 107995 12427 56150 21762 22123 19179 19181 19182 217232 23996 56317 12236 19184 59008 18817 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 96%3359485 Defective CD320 causes MMATC 54219 21452 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME%R-HSA-5619078.3 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) 228368 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense 55932 640703 12363 667035 100041766 22190 236573 14469 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 96%5693606 DNA Double Strand Break Response 70620 667035 22190 107823 68251 20184 240087 11350 70681 70238 27223 100039592 107976 210766 19060 104416 22059 59004 225896 14051 22196 93762 22385 11785 15204 230674 19360 14050 14049 17535 14048 319186 27354 12021 319178 319183 319182 81601 50883 319190 319181 11920 12189 319152 93765 193796 26419 78303 319188 15270 382522 MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 96%1221632 Meiotic synapsis 319178 319183 319182 232440 319190 57321 319176 223697 319181 12189 319152 21749 497652 21750 13006 319169 94244 20842 22196 28113 56739 78303 15267 140557 101185 319188 50878 15270 319168 20962 74075 16906 319167 320558 24061 64009 319565 71846 624153 66654 20957 75459 20843 19357 319186 77053 15512 382522 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 96%420597 Nectin Necl trans heterodimerization 58998 71740 58235 19294 94332 54725 CARDIOGENESIS%REACTOME DATABASE ID RELEASE 96%9733709 Cardiogenesis 20807 81601 54601 12387 13813 20997 57246 14465 17292 16842 21380 21388 15110 18091 214384 12180 14463 17260 140858 15213 14534 15214 17125 15111 17128 16825 16392 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition 17187 12534 12575 211586 13555 19645 21781 12567 12443 11651 12566 11652 12447 27401 12448 20135 12576 19646 12545 17869 73699 22171 21877 13361 19052 19053 51792 12428 17216 17215 17217 17218 17219 17220 12544 50496 13559 104394 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 19650 26441 19651 63955 22390 26442 72568 69077 66997 12530 231506 23997 629959 54124 56436 27214 20459 17463 67177 75660 57296 23834 20422 26445 26446 57441 19172 70024 19173 19175 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18969 18968 66671 19075 19076 17420 12572 59001 67141 66979 50793 18392 18393 66634 26428 26429 56452 18538 68275 68240 19891 18973 18974 433759 23797 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination 208595 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME%R-HSA-5619089.4 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) 104245 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance 93835 11806 110611 65969 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes 29813 328572 12532 59092 78893 13496 12534 69125 18983 12428 12575 211586 13555 219103 52846 21781 12566 59035 20620 231464 12028 12447 18148 12227 66214 12448 58184 12576 18538 52679 104394 234594 12795 15469 12427 55948 22059 13197 20878 108961 53621 72068 232791 104625 19650 228140 19651 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 96%5357786 TNFR1-induced proapoptotic signaling 56480 22030 56489 11796 11798 21937 71648 30941 229603 22258 268749 106025 21926 74256 53376 263876 76580 71609 21929 14082 24105 12370 19766 11797 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 96%5660526 Response to metal ions 13007 17752 104069 17748 17750 17751 17764 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 21943 53859 22030 72049 22031 50930 21944 11796 21934 21947 27279 24099 17000 16994 16992 11797 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 96%2473224 Antagonism of Activin by Follistatin 14313 83554 16324 16323 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 14702 240444 14696 14526 19088 238076 19087 19084 238276 14697 14710 14699 66066 14700 16438 16439 14688 18747 14708 109905 14706 14704 14695 14652 224129 16440 11512 16500 14693 11514 268345 29875 64337 14709 18749 14701 56508 223864 19085 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination 50933 22201 22209 53323 70620 140499 269523 12042 66105 22213 667035 67128 22190 22214 67615 268470 66799 109331 231380 67196 15007 22195 319186 319178 319183 319182 319190 22225 19090 22284 319181 109161 22193 100041766 216150 93765 68366 18538 20585 76246 108089 214498 225131 67819 56273 66317 668173 103737 72129 252870 19302 235497 66510 22083 268281 68441 109815 432940 233900 320311 54624 78303 319188 216080 68612 22210 22194 58186 100039535 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 96%9662360 Sensory processing of sound by inner hair cells of the cochlea 13823 17913 227357 192140 13409 238021 332309 97031 20742 56506 102502 224796 72088 67972 98845 328789 56226 60613 16531 433899 16533 13860 17886 329421 22350 19230 19339 13002 20964 56808 12296 240899 83762 26875 12343 12345 12217 12289 216227 29866 20977 12340 241431 73750 12361 140476 16470 17910 22318 19684 23999 20614 22295 17921 20907 17698 667663 381375 193385 20776 20740 11994 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 96%1566948 Elastic fibre formation 16998 16949 94352 16950 320910 67573 12159 108075 16420 241226 12154 16419 18550 17150 216760 76293 14115 14114 12162 50530 23876 216616 14119 12156 58859 16412 14563 13717 16410 16416 21803 21808 16402 14118 22370 21809 268977 16997 16948 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 96%448424 Interleukin-17 signaling 12234 257630 171095 21402 73086 16150 16151 192656 16179 26965 667035 26416 22190 17258 26410 26409 26413 103583 257632 26417 107607 19094 102626 231130 73699 26395 110651 108960 20112 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 21770 26399 26400 26398 26420 13712 26414 16172 26397 17260 66513 93765 66589 23939 50905 22034 66724 68652 16171 20111 11909 26419 12675 140806 16476 18033 234836 57890 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%R-HSA-110328.4 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 319178 319183 319182 232440 319190 57321 319176 319181 17193 234258 71726 319152 382913 18294 21749 72774 497652 18207 21750 319169 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559586 DNA Damage Telomere Stress Induced Senescence 232440 12575 19645 12566 12447 12448 12576 22059 15364 28113 15267 101185 15260 319168 319167 19360 75560 56702 50709 17535 14957 50708 14958 319186 27354 319178 319183 319182 81601 80838 66403 12428 319190 15361 57321 319176 319181 11920 319152 104248 21749 497652 21750 319169 12427 170644 78303 319188 15270 16906 624153 382522 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants 16590 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 96%3238698 WNT ligand biogenesis and trafficking 73130 93735 22415 22413 22416 22420 22418 22422 22412 22421 216795 22423 22410 20890 22414 22411 22408 22409 53627 22417 68151 22419 56433 30930 65114 54198 RET SIGNALING%REACTOME DATABASE ID RELEASE 96%8853659 RET signaling 14389 13449 74769 13448 18707 14573 14783 14587 14586 14585 14786 18710 19197 14588 23939 19247 20416 327826 18747 19713 20418 58234 14388 20662 18749 623279 18803 76829 114255 18750 18708 384783 18188 18709 110351 18706 11876 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) 67103 15446 17001 11684 11690 11689 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling 268980 18183 83961 320207 100042150 20779 17295 11651 22324 18710 14255 26413 26417 14360 327826 13649 21802 73699 19052 19053 51792 30955 18708 18709 18706 226849 108083 225849 74769 18707 26931 12487 21770 12519 26932 12524 12223 71920 13874 15200 211323 77125 19354 12064 14388 15234 17082 18212 18205 78405 11839 13645 80903 384783 14186 14165 83490 18596 14389 77647 16367 18213 14172 80857 16334 14170 14180 14178 14177 67112 64654 14175 14174 14173 14164 83379 17874 16179 13983 266632 13982 18595 15937 12478 18591 56212 16337 18718 19353 14256 19247 22034 104709 13866 18720 18719 18717 16818 16590 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes 56187 19352 209456 225655 21933 69076 60599 11920 12662 22061 16009 66813 22062 71361 12028 12122 64058 68428 12914 66494 17988 11799 12177 22059 57913 14102 68742 12366 268973 11783 12362 12368 21981 12905 12053 PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 327826 80857 14180 14177 67112 64654 14175 14174 14388 14173 14164 18708 19247 14165 18706 DISEASE%REACTOME%R-HSA-1643685.19 Disease 56208 66383 67443 78610 117591 12389 114479 18126 22325 15452 22017 100042069 23917 57257 171210 19877 15381 11465 22352 19298 19878 70233 67224 378425 19655 218978 218035 15516 73075 66999 269061 70616 66892 68598 67959 12539 12609 17395 100040603 232989 269338 107701 67480 66286 72047 74326 67500 56298 17755 18452 16172 75956 18550 66861 56031 21812 80744 21813 69550 218490 22365 66101 19035 66270 70225 69019 18451 13684 80743 18655 68879 28185 320632 208643 67418 22084 212880 66585 108098 74351 83486 74370 216705 66877 56529 23983 18521 67605 83701 57905 68479 109652 77573 56216 13690 20980 15569 64176 209416 22317 66172 64051 20222 22318 320452 20614 67838 20979 60321 20907 192191 75209 24088 11789 21897 20505 14469 142681 78334 20531 17713 257630 66070 23845 66810 319322 12282 20683 233726 66397 19205 27967 20933 76936 171095 12412 69608 15006 218811 71702 27061 99683 68981 20639 229279 235623 240095 667803 23881 101943 81898 67439 94315 107476 20646 27041 381379 14991 14262 192159 71514 77371 23806 11993 55932 20334 67219 170779 21899 20390 53317 15382 70686 170761 53379 56258 66371 59013 14939 98758 11991 68953 217365 16176 11834 75608 234852 12362 20168 15388 18571 15387 12363 12785 228545 66055 17002 16396 236573 208092 68816 12370 81910 66700 230861 19766 76199 67197 56532 213539 22230 54633 16173 67465 22030 66624 56445 73158 69192 12721 71732 69146 53902 14827 67285 236732 223697 67958 68183 105513 76479 16175 20624 66642 54722 233405 434174 64685 71609 68137 14082 75062 20520 77134 27366 228005 76687 13205 28000 13204 246728 76938 16171 233908 66125 67561 11931 11932 11933 56188 16514 12322 12323 108058 12325 229709 16438 16439 18747 11928 98660 232975 117149 12491 57780 20193 16440 53627 59095 20928 108017 238037 22166 14630 17246 26400 26398 26420 12578 16193 14629 15977 26419 12608 12064 14388 18212 18205 107971 78405 18803 11839 13645 12048 13629 67160 18011 13388 16449 240055 225164 11487 54485 11491 16450 107686 384091 666609 216766 621705 20595 66603 53975 276919 20641 20638 69731 432803 67332 76007 20927 12266 625018 14917 69983 226413 229782 56774 30962 20532 74338 20510 102680 20512 20540 246049 17254 103534 57377 27801 228136 75965 70546 108687 269181 57437 217664 69035 107895 20446 20444 20442 20443 17308 17158 20440 67569 14376 20447 71164 53618 20448 227619 19089 208884 12326 217344 20620 93671 16153 17886 70625 68975 234959 94112 15213 70208 21849 13649 14184 21802 74126 14723 55948 23942 56771 50493 21825 80509 22160 14539 16477 56310 26896 103988 14534 19664 216848 232232 17200 18129 18131 18132 107932 170787 18148 19211 100039786 19712 229542 67279 70315 21349 13866 216227 18519 15370 18478 18854 79221 59024 327987 192292 11350 67384 17126 17127 17128 17192 58992 16621 75475 103806 333639 69790 22608 16653 381022 14377 56458 16179 13983 75613 16399 16401 16154 56338 264064 18591 54601 83814 15185 15184 216154 51813 15469 69792 15205 20466 67381 15182 20602 23989 270118 12005 234366 28077 56233 224139 15214 171285 194231 54519 29875 245684 22371 16416 110157 23980 14161 21894 207958 215449 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 16706 13191 18174 74591 53945 27413 11416 27421 20521 19300 108664 54403 20538 238384 26569 246787 22232 23985 72027 13487 74104 20501 104245 12215 20516 15203 18670 68421 28253 170441 71279 317750 12870 24059 56480 54131 58203 236794 331004 12040 12041 13171 13382 12039 14235 18646 54167 232679 93835 19682 18453 65969 232174 11303 11771 546726 11772 71770 232910 11773 110611 18749 15926 12984 12982 23971 23972 14387 18295 14385 14595 15275 17022 75612 269941 108902 218271 14264 105193 15529 23888 20971 14635 74246 319625 20969 14430 50917 16548 71951 20970 14735 53412 19895 14043 14042 15530 13521 27419 13806 103978 18563 235504 14733 53374 13070 13853 68401 20525 14734 116847 117592 21351 21391 72136 225913 232493 14936 74185 27357 11304 11603 16545 67880 231103 72157 27029 56773 72727 27047 56737 320438 208624 230163 102580 24070 208211 381903 13478 328370 12475 22031 56489 106759 13072 13079 14256 116871 51810 116870 18950 11486 11821 67470 27409 14423 214424 328417 606496 67287 80285 52552 671535 547253 19092 17161 78798 268980 13666 215114 12211 19043 19084 14025 11682 234258 18294 72774 18207 107305 72543 27681 70160 194309 52348 116733 73711 22088 67123 330192 28084 76959 66201 20479 66914 233870 360013 432508 67529 13047 83490 18596 93687 77647 18213 12057 170786 19349 22139 16573 16412 140579 94176 330662 20430 59079 56212 19045 19046 110119 54128 14083 27410 17925 18458 13138 17973 12767 18186 19087 227697 19025 50798 57357 14583 13480 67533 13481 228368 24060 52014 68563 67422 18010 50528 70008 171283 12223 71920 13874 13712 15200 18412 11840 15481 17210 116849 238505 11720 210009 269378 12846 80903 384783 75669 14186 14165 81897 14389 16367 14172 80857 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 14164 83379 12780 16194 69116 56791 380928 50868 22200 75717 66663 22346 74153 22201 74244 13123 104086 21452 75590 231380 18218 63953 672511 15234 12695 224912 56217 14854 13017 13016 50884 83767 329165 71893 110279 105855 242687 237038 11308 241275 13057 108100 101314 18969 18968 13436 13435 13433 19075 19076 12261 18595 20537 20526 13162 19164 19165 15208 100042305 208117 59287 77974 100039623 56198 18400 15162 12526 140580 109637 17075 19088 234779 17918 19108 12499 12267 20897 76709 73178 104110 20963 14678 14677 12229 56443 14687 19200 14679 432530 210044 104111 80987 68089 67771 11867 54483 56378 18438 66713 74117 13542 70086 224129 245880 11512 11513 11514 11515 14191 13544 13543 22376 215280 14598 18439 319446 68524 67955 13035 11541 23959 23887 17882 14129 242851 19085 17913 13479 58861 246256 14131 17909 66824 330319 216799 76884 12495 19720 21951 74493 16881 12527 19771 211323 79235 192656 17874 214111 257632 266632 53791 107607 108960 19662 235584 67603 26372 56463 26936 19659 21848 11774 330286 67726 100986 78781 19317 11610 76156 210106 66549 16905 67095 14359 69923 338523 75296 69940 107338 109181 234130 73016 84035 56811 207742 16974 13380 16973 22154 16593 16834 54214 70297 14724 54368 14729 24127 20851 20850 18712 50490 14784 71519 13078 99982 14228 13207 107351 100043508 17698 108147 20742 14183 394436 394433 242585 21762 22123 12675 19179 19181 19182 23996 110446 19184 18033 26440 19166 18035 19167 18036 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 14156 26446 19172 19173 19175 19697 13682 19177 13681 21402 16150 26443 26444 16151 19170 66413 26965 667035 22190 59029 26409 67089 70247 13982 14815 208727 22196 621893 319162 319173 319163 170743 19360 58988 170744 17535 21975 54445 19363 142980 19364 27354 12021 317677 17195 81601 17532 327762 12259 19361 56392 114714 22427 19718 69263 15574 109821 11920 12189 12190 72512 235610 54123 231724 237911 19355 22596 57434 13211 225182 14375 214763 20388 26909 235559 12144 68275 14067 106344 69162 72151 68240 233826 19891 19367 19356 19362 217232 56317 59008 14069 66156 216080 69957 17222 21787 75430 68612 52563 22194 68999 52206 100039535 52717 99152 668450 12388 12387 58194 12550 20408 12402 56324 20779 15239 20404 17295 20844 20405 13858 104836 109880 26416 12928 13075 26413 26417 20416 327826 109905 54401 26395 26396 18176 20662 15461 217214 11898 109900 227231 18408 18416 67824 11846 19014 328572 15129 17087 15368 15122 21372 11806 103573 81004 21898 18024 15183 20185 12914 640703 268373 14225 12334 12336 11666 20656 56484 16476 69543 18477 21672 16542 16906 66899 22627 14011 12569 668218 12568 11820 99412 12125 12530 12531 14103 12532 12380 12333 63993 18128 56438 14697 14710 14699 66066 14700 14708 14706 14704 14695 14693 20423 64337 14709 108138 14701 319583 13363 14702 14696 14367 14366 22416 16453 16177 22418 54721 14370 50724 60406 13609 20847 15980 17060 15979 14368 58799 12518 14369 217864 15985 15975 94246 14688 18391 100041953 16147 110606 26554 71954 107392 18015 14272 238247 15353 68219 101809 98985 228410 114715 54451 114716 108062 67337 83410 18789 51786 94230 74320 68188 29873 13003 110006 15586 15212 15211 12032 13179 15932 12091 11881 15931 12111 121021 13004 12575 22589 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 56371 27401 13163 20389 12448 12577 12576 14255 14182 20495 216965 20497 234663 107723 19047 19386 73699 12015 12371 68097 19052 19053 51792 445007 226849 225849 26931 21770 26932 57294 56455 69912 76246 214498 103468 66317 235661 235497 56430 234865 22083 59015 54624 69736 17069 110379 68032 17289 13427 14828 19128 276891 13426 217303 22174 13424 14456 26362 17533 100732 18861 52898 17685 12737 17686 17350 320997 17688 11998 20387 54140 26361 12000 16364 21872 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 101772 110821 24018 66904 17420 17850 67897 12572 109136 13872 20924 23894 14884 68165 14149 14148 77697 109129 15267 102566 67096 404545 319168 319167 224105 226144 105722 382014 76850 239528 319186 319178 319183 319182 193670 54197 236511 320091 319190 13081 56717 70377 319176 18034 233246 216440 319181 19353 20014 57261 103963 217351 243634 56637 214150 69038 227743 13135 19247 66753 110948 104709 67819 14056 15170 116891 17454 20338 319169 109270 54219 67075 26363 20846 20848 625328 78303 319188 15270 16818 80286 56716 624153 14603 68292 23797 16430 382522 16451 232440 13200 13626 319149 18108 22628 18183 320207 83961 100042150 22612 11651 11652 22324 15077 12047 269523 66310 18710 140858 18566 52615 244209 19646 213464 14360 12988 13001 13000 100039026 17869 245688 12502 17096 12638 23808 12504 244373 18005 78757 76580 100088 30955 12774 18708 19385 18709 18107 18706 18607 74769 18707 66357 12487 12519 12524 21416 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 19354 114741 20201 72504 20202 21343 209361 93747 226182 12454 229906 235459 24074 83602 58202 68153 74197 67923 19123 27224 71586 27632 230073 24116 66641 12455 71956 72949 228607 13716 217069 63856 20817 14609 20815 16001 13051 19345 271457 19344 20533 19743 11461 22059 170762 108989 231042 227699 223921 227720 269113 66679 18141 23825 107939 69482 71805 11739 433923 11740 54563 16646 226861 19069 15361 70699 101739 72787 18226 218210 59069 19248 108153 23794 30806 108154 16795 27207 210417 67097 271127 670832 229595 231413 208936 633683 77739 20044 381694 27050 269959 667279 14425 20085 269328 668144 230145 20084 100689 67186 233744 382492 235130 20055 240322 75617 20357 27370 16848 65019 11504 629957 20356 20102 17829 21803 18636 20103 100039649 668668 21826 667739 140474 54188 224116 67300 226866 672214 217734 12757 17063 66481 59048 225058 240913 100038875 223838 100038991 99011 68028 237360 100043000 330119 67891 216725 100043295 73732 622534 66548 238217 330267 74568 207596 16785 224697 666669 56229 100040021 353328 67025 239337 100043391 68273 668182 77794 241053 94192 12317 279028 432502 100038882 19989 76808 19899 100043184 19921 19934 100043755 11545 193740 12330 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 16211 100039592 16648 19106 100037258 100043876 100043893 100043423 100042986 20115 67281 54196 76846 625646 100040298 68172 100042740 19951 381686 16649 70572 19384 667618 100040970 267019 56040 67248 100040331 67941 66789 13115 14104 110115 14061 64340 622469 225027 67996 51796 71713 233073 20382 110809 20383 21681 108014 192170 69207 19826 22637 100040029 78038 243382 227095 11992 72039 56357 72345 22021 56316 14058 14071 22022 14268 15568 22370 15007 12010 12258 11768 11769 12478 108012 11764 107975 11765 11767 252903 12759 13074 100041766 66513 93765 66589 22034 66724 68652 52120 242864 17169 22631 22629 27267 18976 433759 16590 319189 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960519 CASP4-mediated substrate cleavage 12367 16176 16173 12363 69146 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME%R-HSA-8853884.3 Transcriptional Regulation by VENTX 52717 233833 99152 668450 12387 236511 21416 110147 19697 16842 12443 213988 217351 56371 214150 12578 16193 17454 12608 22059 217232 56317 77683 59008 18033 66156 216080 69957 17222 75430 68612 12978 52563 22194 76850 68999 52206 100039535 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 96%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) 73166 13595 15490 98386 13121 13360 74754 235293 66234 18194 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%71064 Lysine catabolism 235386 78920 13382 30956 110695 23923 19193 209692 270076 12971 217593 72947 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 96%9769739 Regulation of clotting cascade 19152 14066 217847 279028 14068 11905 15160 14058 14071 66901 18787 15529 11603 23888 20971 20969 14723 22371 71951 20970 58992 16621 14735 12258 105722 14724 56744 54368 14729 15530 21824 233246 109821 14062 20720 14061 268591 103978 19124 20597 68891 14733 14067 385643 14734 19123 14069 19128 11820 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9656256 Defective OGG1 Substrate Processing 18294 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME DATABASE ID RELEASE 96%9634815 Transcriptional Regulation by NPAS4 233833 20807 16334 236511 17246 59027 243621 225872 56461 103573 213988 20620 217351 214150 11863 26413 26417 11864 12914 52897 19712 54526 19713 17454 14815 12064 14579 14281 12569 12568 11865 76850 239528 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication 216151 74528 208194 381760 226153 21975 19819 50776 18975 COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation 26432 26433 210530 56401 76477 18542 234407 192897 69675 16403 12817 12816 12815 24087 12814 21892 12831 12153 12813 94216 12830 373864 12821 107581 77018 12819 53867 12829 12828 12827 12826 12825 69700 12824 16780 12822 71355 12841 16782 12823 73368 18810 12840 213945 16774 12818 245026 140709 13040 237759 12839 13030 329941 12837 12836 12835 12834 16948 12833 12843 16949 12832 12842 94352 16950 67573 17395 13039 17392 17386 18453 18452 19035 18451 30800 12476 320452 17393 56693 269132 237360 14789 330119 12406 216725 18822 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 96%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 11438 110834 11449 11448 11447 108015 11444 MET ACTIVATES RAP1 AND RAC1%REACTOME%R-HSA-8875555.2 MET activates RAP1 and RAC1 19353 109905 107746 12929 215449 12928 67299 14388 15234 17295 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%5661270 Formation of xylulose-5-phosphate 68631 102448 67880 20322 58810 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 96%8935964 RUNX1 regulates expression of components of tight junctions 12741 12400 21872 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 96%8878166 Transcriptional regulation by RUNX2 12020 12534 20682 56275 12575 19645 20779 12567 22612 12443 11651 11652 13345 27401 97064 16656 26413 26417 107568 15213 11350 15214 22601 17125 15111 17128 17130 22160 17132 13395 12400 19017 16854 53892 223272 68527 15183 21762 22123 14634 14633 19179 19181 19182 23996 19184 75788 26440 19166 170826 19167 170574 26441 26442 69077 66997 23997 56436 17463 57296 20422 26445 225207 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 13982 11835 14815 26379 208727 16402 12842 17386 56424 12028 15185 56637 16147 12156 212712 15205 20846 17702 23797 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 96%74713 IRS activation 16367 16334 14783 384783 16337 REGULATION OF NF-KAPPA B SIGNALING%REACTOME DATABASE ID RELEASE 96%9758274 Regulation of NF-kappa B signaling 80750 223664 22030 270151 67454 22059 12675 16150 59025 16151 667035 22190 24110 22034 12370 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-HSA-446353.3 Cell-extracellular matrix interactions 109711 16412 73341 68794 20163 21754 19303 170736 22323 74202 57342 218952 16202 225341 192176 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 96%379397 Enzymatic degradation of dopamine by COMT 17161 12846 791260 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC 12469 12461 12464 73710 22145 53857 12465 22152 545486 227613 238463 22153 12466 22147 21454 12462 22142 22151 22146 12467 12468 22143 67951 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 96%3371378 Regulation by c-FLIP 14103 22030 71609 14082 22035 21933 12370 19766 14102 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190371 FGFR3b ligand binding and activation 14172 80857 14180 14164 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 96%9705462 Inactivation of CSF3 (G-CSF) signaling 12986 16451 19823 67923 75717 12702 17096 20846 20851 20848 20850 54721 20963 66105 12985 216080 667035 100041766 15162 22190 12703 16452 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway 240095 667803 13039 15007 13040 12010 15006 14991 240028 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis 22247 69719 56749 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%8874177 ATF6B (ATF6-beta) activates chaperones 12915 270669 14828 56453 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 96%75892 Platelet Adhesion to exposed collagen 213119 16412 14127 243816 14723 279028 17096 22371 109700 16398 14724 54368 14360 14729 REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 96%9861718 Regulation of pyruvate metabolism 14874 17436 667035 22190 13382 27418 74125 226757 56705 381511 68263 228026 18604 236900 27273 68477 75387 18004 66089 27402 18597 18598 382051 319518 16828 66771 76425 59003 235339 INTERLEUKIN-1 PROCESSING%REACTOME%R-HSA-448706.3 Interleukin-1 processing 16176 16175 12362 16173 18033 13035 19697 69146 18034 KINESINS%REACTOME DATABASE ID RELEASE 96%983189 Kinesins 26934 74947 16570 16594 229841 668303 16579 232943 240641 269152 19348 16565 16564 16552 71819 16580 16581 16593 16551 16561 110033 16562 16558 209737 70218 73470 74764 16563 75050 16554 286942 16568 16578 319991 16572 16573 16560 16569 16571 73804 228421 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME%R-HSA-168330.5 Viral RNP Complexes in the Host Cell Nucleus 193740 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351202 Metabolism of polyamines 56436 242669 17463 57296 54375 20422 26445 26446 20810 19172 19173 19175 671878 75986 19177 26443 26444 19170 66413 18104 20229 59029 67089 70247 18247 18245 18263 21762 22123 19179 212503 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 53814 23997 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME%R-HSA-5619104.4 Defective SLC12A1 causes Bartter syndrome 1 (BS1) 20495 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%446203 Asparagine N-linked glycosylation 193813 12068 53618 317717 20448 56494 227619 60409 19089 89867 13200 235416 216131 107338 67231 66890 269523 338366 12640 224139 21802 74126 207958 53598 66357 56444 67665 104318 22428 13191 192193 12344 59288 105785 66967 223455 66597 320011 108123 23802 108124 22644 66435 75841 76332 16834 102339 99412 338337 17957 67542 66397 97484 233824 69608 218811 99683 192156 56418 70361 77371 380959 20334 66251 56447 54161 225896 12836 11889 11890 59007 56389 59042 14827 56395 16866 68137 66913 12343 12345 98388 11842 110119 69080 331026 29858 50797 12340 54128 70349 12847 20739 20740 12091 54160 11733 11735 14595 66111 640524 15275 20742 12317 20741 54399 20743 217615 50935 12330 67311 68947 225742 236082 107652 26938 80297 20451 19703 245847 234663 227697 20445 20449 54342 19025 109154 14422 50798 54613 66174 213827 57357 50877 11844 56174 53334 14583 22242 13480 14584 68097 234730 13481 22122 241230 217364 75540 67511 228368 66248 56358 24060 240119 218138 20454 109785 52014 12764 20450 66789 57170 69064 94181 74091 68563 67422 14799 20452 18010 241159 56455 23956 71665 56336 56386 235504 242362 11840 19359 64138 235661 18195 19179 57370 53418 56375 110379 11839 13427 13426 13424 16334 17309 667035 22190 77038 56737 320438 208624 102580 24070 208211 193670 381903 54197 13478 328370 69654 216440 20014 228998 103963 69038 17155 67091 13135 17156 20703 230815 11843 66226 19324 105522 243819 14067 69162 67819 14275 12793 67857 100042773 116891 20333 215474 20338 207352 74498 66682 103534 52036 67075 57377 76983 13032 245828 12794 54130 240667 108687 67727 269181 214895 59005 217664 14069 78232 107895 56041 20446 333883 20444 21787 20442 27096 80286 20443 72978 17308 227648 17158 76308 68292 20440 76510 67569 100042343 16430 14376 50907 20447 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling 16193 20848 54721 16451 12402 16194 19247 16452 12702 20846 16195 SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL 14106 66556 620395 11481 17126 23863 17127 12622 17128 18119 13590 269275 11479 56484 18550 18553 11480 320202 26413 26417 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation 319178 319183 319182 232440 319190 319149 319176 319181 15077 13436 18140 13435 13433 319169 625328 54427 15267 78303 319188 319168 15270 319167 624153 319186 382522 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111461 Cytochrome c-mediated apoptotic response 56369 12367 670717 11783 74268 72565 66593 12371 26413 11798 26417 12369 REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 96%877312 Regulation of IFNG signaling 16451 56469 15170 15980 19246 15979 12703 19247 16452 12702 15978 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) 20512 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 96%5654221 Phospholipase C-mediated cascade; FGFR2 14172 80857 14180 14178 14177 67112 64654 14175 14174 14173 14164 18803 80903 14165 CHD1 AND CHD2 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943411 CHD1 and CHD2 subfamily 319322 232440 319149 27967 107686 384091 666609 68981 21423 20639 15077 20641 101943 20638 81898 20646 67332 21406 15267 319168 319167 66055 319186 319178 319183 67959 319182 67465 319190 107701 72047 319176 319181 67958 20833 76479 75062 12648 244059 114741 76246 13204 214498 76938 66317 66125 212880 21413 235497 319169 22083 17927 17928 54624 68479 625328 78303 319188 15270 20222 624153 382522 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling 13866 211323 14786 100042150 DNA DAMAGE REVERSAL%REACTOME%R-HSA-73942.4 DNA Damage Reversal 268420 69113 69090 75452 17314 77987 231642 26383 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME%R-HSA-389977.4 Post-chaperonin tubulin folding pathway 21371 66411 108903 73710 72726 22145 53857 22152 545486 227613 238463 22153 22147 56327 22151 22142 70430 22146 22143 67951 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 96%5686938 Regulation of TLR by endogenous ligand 17087 12491 21899 20193 12475 69146 238055 14161 54722 434174 170743 21898 24088 21897 20201 110135 20202 99571 16803 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells 76113 17523 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 96%1592389 Activation of Matrix Metalloproteinases 13038 17395 17228 13039 17392 17386 17394 17384 17388 23948 50701 17229 83995 72902 18550 240047 22072 17391 66473 17390 21858 21857 18815 12822 17385 17387 16621 17389 17393 13035 INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion 18550 102566 404545 320091 243634 101772 50528 70008 105722 382014 233246 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654710 PI-3K cascade:FGFR3 327826 14172 80857 14180 64654 14175 14388 14173 14164 80903 18708 19247 18706 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 96%110312 Translesion synthesis by REV1 68275 106344 72151 68240 19891 19687 19718 69263 19714 71890 56210 667035 22190 18538 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) 11998 12000 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade 14919 18108 107477 14913 245650 73582 14685 20215 12788 214111 212541 14699 18761 75624 14688 110606 640703 14272 24013 56307 237178 243923 225600 18750 18107 18587 18588 19674 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%180689 APOBEC3G mediated resistance to HIV-1 infection 23825 268373 15361 101739 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 96%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 15926 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 96%111459 Activation of caspases through apoptosome-mediated cleavage 12367 670717 11783 12371 11798 12369 EGFR DOWNREGULATION%REACTOME%R-HSA-182971.8 EGFR downregulation 58194 20408 12402 56324 24063 24064 19272 12223 15239 20404 71920 13874 20844 20405 15200 13858 19248 667035 22190 13854 54126 13649 21802 13859 11839 13645 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 96%8985586 SLIT2:ROBO1 increases RHOA activity 19876 11848 20563 17925 VLDL CLEARANCE%REACTOME%R-HSA-8964046.2 VLDL clearance 171504 11812 22359 238055 11425 54135 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE 102098 20663 12367 22324 277360 667035 22190 18049 22325 622434 545156 16443 12015 57257 19164 20662 17207 19165 12366 100042305 16800 208117 59287 100039623 13605 12070 109904 230972 213498 207212 71704 234094 223435 56349 16801 94275 19418 75547 19353 18053 72754 18412 69632 213649 24001 224014 56321 230098 53972 30938 77669 22034 442801 226970 54126 101497 67733 269608 328967 14163 26382 268739 26419 14674 73341 21844 22627 12125 236915 109934 COMPLEX I BIOGENESIS%REACTOME%R-HSA-6799198.5 Complex I biogenesis 66690 76826 69702 67264 208501 54405 17991 66091 69487 108755 239760 66414 68472 104130 75597 66928 624814 68493 76947 26940 100900 67273 68198 66495 67130 68202 66416 68375 66108 68342 66377 68197 227197 67184 100042503 66046 230075 66916 66218 69089 70316 17721 17722 17716 17717 17718 17719 229211 225887 72900 226646 17995 595136 623286 66706 235169 78330 66349 76916 75406 15526 73694 94281 66271 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 96%9927020 Heme assimilation 15129 15122 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) 15586 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family 56619 269328 353328 26888 14127 381809 17312 234779 56620 17474 17096 17829 100039649 20963 140474 224116 17063 14360 73732 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME%R-HSA-5205685.9 PINK1-PRKN Mediated Mitophagy 56480 67443 71648 67526 11793 66734 18412 66105 245860 667035 100041766 22190 66410 93765 22334 66589 22333 22335 66169 28185 100043869 53333 66119 22195 67414 50873 170731 223696 68943 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%73762 RNA Polymerase I Transcription Initiation 216848 319955 106298 110147 667501 107932 21374 21429 20019 21340 21339 21341 64424 22130 13871 75316 66420 70333 69833 66136 245841 20017 19646 234366 116871 14885 209357 66467 116870 20018 66671 17749 245688 100043714 14534 20016 17420 12572 18519 13872 23894 14884 23942 17192 433759 15182 229542 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation 11350 12842 15213 12400 225207 15214 22601 11835 212712 19645 20779 14634 22612 15205 15185 97064 68527 170574 17132 15183 26413 26417 PRIMITIVE STREAK FORMATION%REACTOME%R-HSA-9754189.5 Primitive streak formation 14106 12387 21414 12159 13813 20997 14836 27217 94093 20674 16842 17126 17127 17128 227606 18999 100038891 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease 327826 15461 18803 18708 14186 18176 14388 18706 20662 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins 13823 14811 14810 23859 14814 14813 192167 54525 20910 57267 228836 226352 242667 56376 171180 216856 58234 13385 26558 26557 216028 53310 74342 26556 243961 217692 107065 13169 380785 106025 13822 14816 269587 224997 108071 245537 18189 18190 11784 22343 54526 60510 14812 108030 20980 12361 20979 20907 319924 22342 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 96%420029 Tight junction interactions 56863 12737 75677 16456 53624 93742 56513 12739 12740 56492 18759 621628 56173 242653 239931 58220 18417 114141 12695 224912 64945 56217 12741 71908 60363 54420 58187 54419 12738 93737 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME DATABASE ID RELEASE 96%450531 Regulation of mRNA stability by proteins that bind AU-rich elements 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 11651 26444 19170 66413 238799 193740 667035 26416 22190 22695 59029 67089 70247 19094 15507 54401 18753 17164 15568 11737 69583 671392 66362 227720 109075 66583 27998 72544 50911 69639 24127 72662 66446 227715 74108 70640 75901 103573 12192 15481 208643 22631 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 18750 26442 69077 66997 23997 18458 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 96%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 20848 12122 12043 12048 12015 12125 171543 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME%R-HSA-9723907.3 Loss of Function of TP53 in Cancer 22059 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9026357 NTF4 activates NTRK2 (TRKB) signaling 18212 78405 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 74769 18707 13856 13857 30955 320207 18708 384783 16452 17096 14388 18706 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis 17913 246256 17973 17909 105855 242687 330319 76884 22612 11308 22324 17886 108100 12928 11461 101314 26413 26417 14360 22325 11350 12502 57257 140579 17096 330662 11465 15162 140580 20430 17918 76709 19353 73178 20963 12229 56443 80987 68089 67771 11867 56378 66713 74117 245880 14191 14083 22376 215280 68524 50884 17925 83767 17882 329165 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 96%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) 100929 68260 329504 76357 209584 68736 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS 22324 15461 13856 13857 107746 12929 384783 16452 17096 18176 20662 20416 DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 93835 14603 65969 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 96%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) 20516 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 18970 11792 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation 16706 225849 26931 17532 21770 26932 56392 20779 12322 109880 12323 108058 19046 12325 640703 19047 17169 54401 73699 26395 26396 18176 15461 110157 19052 19053 51792 11836 26403 72399 18673 16452 226849 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764260 Regulation of Expression and Function of Type II Classical Cadherins 12385 233833 59058 110751 20665 12564 15426 24136 12388 16201 12387 236511 20613 20683 12552 57875 15227 213988 217351 214150 230738 227485 17454 56198 16480 76850 77630 239528 11492 239096 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME%R-HSA-9652282.4 Drug-mediated inhibition of ERBB2 signaling 13866 59079 12539 15519 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 96%111463 SMAC (DIABLO) binds to IAPs 12367 670717 11783 66593 12371 11798 12369 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020956 Interleukin-27 signaling 20848 54721 16451 50498 12330 12931 16452 20846 50931 246779 16195 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 96%5083636 Defective GALNT12 causes CRCS1 100039649 140474 224116 269328 353328 230145 17063 73732 17829 DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions 74769 23845 58217 234779 15006 19353 20963 667803 12229 668101 14360 217304 22325 217306 16643 83433 57257 18176 20662 22177 15461 620235 17444 18803 16818 12010 18708 16822 18709 27007 18706 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding 11434 71564 73456 12527 75510 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 96%480985 Synthesis of dolichyl-phosphate-glucose 66248 66174 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8866423 VLDL assembly 17777 11812 238055 11425 18453 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 16514 26443 26444 12780 19170 269523 66413 667035 22190 59029 67089 70247 20927 20928 12638 244373 226144 193670 54197 11806 70377 216440 11303 74591 27413 27421 19300 66753 67819 116891 20338 74104 21762 22123 18670 68421 67470 19179 27409 19181 11666 27410 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170968 Frs2-mediated activation 327826 109905 107746 109880 12929 54401 18049 26395 26396 26413 26417 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8941855 RUNX3 regulates CDKN1A transcription 21803 12575 11906 22059 12399 17127 17128 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint 12234 93687 56436 208583 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 26416 22190 59029 67089 103583 70247 19094 12795 50883 56637 21762 22123 19179 19181 12649 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 12530 23997 27373 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013148 CDC42 GTPase cycle 214230 330319 12389 241656 22325 57257 29875 52666 217866 105782 14269 22379 13605 214459 66871 236920 26403 226751 13830 76088 16480 18708 18709 18479 213498 243362 234094 98386 50768 18481 404710 19418 208846 69632 213649 224014 53972 30938 66508 442801 226970 54126 101497 14163 26382 14674 73341 21844 210293 71709 22042 236915 109934 106952 233071 26934 75974 110279 12549 56513 216963 192652 239027 212285 71409 70497 244867 22319 20619 192192 11855 319899 277360 260409 192662 57778 263406 11857 226823 14570 108100 216445 19349 69710 18805 26431 70584 68428 216831 56418 70719 71302 71544 229658 101240 544963 622434 66251 78816 72729 104252 16443 231532 14218 71972 225358 17207 214137 171207 94190 16709 77038 218581 58804 21917 56699 224105 109904 230972 223254 102075 56419 104445 19765 259302 223666 14270 223435 117600 330914 232906 71435 228359 213783 100038946 545481 23853 73178 219140 226652 78514 22376 215280 68524 17925 67299 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 328572 12843 20602 20683 211586 17283 21781 22284 228839 83814 18550 11545 16477 66105 667035 97064 22190 107951 93836 26413 18787 20185 26417 67821 12579 22608 12454 13559 20482 104394 20481 51813 17869 94093 19042 17126 17127 12455 17128 72949 66313 433759 216080 17131 19650 21815 264064 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%194002 Glucocorticoid biosynthesis 18976 15484 110115 15483 12401 13072 15492 13074 15497 13079 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription 14632 14634 14633 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 96%170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 103988 103468 19386 231103 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination 15161 75302 68837 56208 12534 22223 50933 17425 71599 228790 56324 15239 20844 269523 12005 101206 17869 15925 15251 12638 84585 100683 218214 109689 12006 216869 328572 101565 14462 216185 21812 21813 18002 28185 100043869 14534 71586 230073 71956 228607 217069 11789 12530 11848 11555 100756 53376 19211 170711 11461 54644 70527 74270 76630 71472 66124 104416 83563 22059 66889 74112 30941 216825 229603 414084 22258 74256 21929 50873 19766 54198 11797 22230 14232 246103 22030 69641 18970 108155 11796 59040 71954 18519 21803 170822 235323 74996 67561 319651 22632 224836 14479 360216 216799 107260 56207 84092 72607 68031 110616 73162 21951 74493 22217 68149 27401 170707 235441 22334 22333 57783 22335 226418 109359 217057 327799 17125 17126 17127 17128 66313 17131 76800 70675 17248 30940 12428 17246 22225 22284 320713 56456 22224 107995 56505 68350 225280 56249 77125 69714 227195 109275 68142 233875 70020 19358 19359 235134 12427 107986 21762 22123 108645 19179 19181 19182 23996 19184 19671 436004 26440 19166 18035 19167 26441 26442 69077 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 16151 19170 192656 66413 667035 22190 59029 26409 67089 24110 68251 257632 20184 70247 269582 70681 107607 13982 231130 107976 210766 11835 59025 621893 319162 15267 319173 319163 319168 319167 319186 319178 12021 319183 319182 54601 319190 22031 319176 319181 12189 66513 22034 50868 252870 319169 78303 319188 216080 319189 20439 382522 110962 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events 18796 18797 18795 12326 14675 19087 19084 12322 12323 108058 12325 26413 229709 16438 16439 18798 18747 14672 100039592 14676 16440 18753 18783 110355 18575 18574 18573 14682 14680 19088 55984 19108 104110 14678 14677 14679 432530 210044 104111 640703 224129 11512 11513 11514 11515 18749 207565 18752 18750 242851 19085 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953078 MPS II - Hunter syndrome (CS DS degradation) 15931 FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 96%9830364 Formation of the nephric duct 279653 12387 19713 12159 15412 16869 18504 14462 67701 114249 14173 13797 15403 15904 231507 14013 18510 23967 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4551638 SUMOylation of chromatin organization proteins 216848 20230 52615 12419 56469 19386 20610 208727 12418 22196 100043429 170762 108989 231042 227699 214669 223921 227720 445007 269113 12151 66679 22658 18141 107939 19763 69482 71805 54383 54563 13619 19069 70699 241915 72787 12416 18226 218210 19821 69912 103468 212712 234865 30951 59015 69736 110379 433759 15182 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 96%5223345 Miscellaneous transport and binding events 19743 13829 18716 58176 56315 70701 212555 11519 236792 12007 100604 214112 433926 241296 83429 233280 72267 380836 74552 11732 27360 67075 93790 11518 231549 80286 223473 AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9612973 Autophagy 93739 22241 56208 67443 78610 21821 74244 269523 66105 107305 72543 22334 22333 194309 18541 52348 15499 22335 15519 73711 22088 13001 67123 13000 234663 330192 100039026 66914 12638 19752 14580 11520 68097 26369 16784 57320 108099 218978 15516 15129 52639 56455 666468 77040 18412 73683 213948 66840 228361 51897 64930 57436 235040 12421 66508 68118 545987 54636 242557 15481 66795 66169 67841 54170 66615 28185 100043869 74781 22084 52187 68576 66096 235661 83409 74370 68441 268706 53333 245670 66119 13427 13426 223696 13424 75669 68943 56480 225326 67526 11793 68146 100756 66734 72018 17966 19305 245860 667035 22190 66371 68953 75608 22195 50873 208092 66700 241113 56717 71648 11920 105513 15185 100041766 66905 66410 93765 66589 13819 97287 105787 108079 19079 74302 108097 56486 67414 19082 56716 170731 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 96%5654743 Signaling by FGFR4 14172 80857 14170 14180 12402 14177 24064 64654 17346 14175 14173 14164 83379 109880 667035 22190 19247 26413 26417 327826 18176 14388 20662 15461 19052 107971 19053 51792 18803 80903 18708 14186 18706 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357769 Caspase activation via extrinsic apoptotic signalling pathway 14103 17087 22030 72993 12475 13144 21933 13176 69635 13143 225471 107449 12371 106759 94275 107448 14102 12367 21898 71609 14082 22035 12370 19766 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) 12091 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428643 Organic anion transport by SLC5 17 25 transporters 27376 235504 241612 13358 67863 216225 GSD II%REACTOME%R-HSA-5357609.5 GSD II 27357 14387 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 14381 12234 56436 17463 57296 20422 26445 26446 20683 19172 19173 21881 19175 17250 19697 19177 18128 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 110208 70247 17869 50493 22166 20657 14630 76408 328572 15368 12013 11911 20293 76650 17436 17135 17134 18412 27407 56637 18104 18024 14859 71389 12578 12914 14629 26357 50868 26570 21762 22123 108079 19179 19181 19182 23996 15926 21351 19184 18033 26440 18477 19166 11839 12043 19167 18590 13645 26441 12048 26442 69077 66997 23997 REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 96%912694 Regulation of IFNA IFNB signaling 54721 16451 15170 20847 15977 19246 19247 12703 12702 24110 15975 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 96%2129379 Molecules associated with elastic fibres 16998 320910 12159 108075 16420 241226 12154 16419 17150 216760 76293 14115 14114 12162 50530 23876 216616 12156 58859 16412 14563 16410 16416 21803 21808 22370 21809 268977 16997 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%71262 Carnitine synthesis 170442 192289 56752 20425 PTEN LOSS OF FUNCTION IN CANCER%REACTOME DATABASE ID RELEASE 96%5674404 PTEN Loss of Function in Cancer 19211 INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling 107527 26419 215274 331461 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5674499 Negative feedback regulation of MAPK pathway 110157 109880 26395 26396 26413 26417 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination 384091 666609 68092 433702 20638 243963 67332 20492 72290 116748 68219 98985 228410 54451 108062 67337 54196 83410 18789 51786 94230 74320 68188 54188 66899 269061 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190322.3 FGFR4 ligand binding and activation 83379 14172 80857 14170 14180 14177 80903 64654 14175 14186 14173 14164 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA 52463 194388 214133 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764560 Regulation of CDH1 Gene Transcription 232440 24136 13626 20683 319149 15376 20586 19645 22431 21423 15077 13345 75339 192173 20901 21417 52615 60611 16601 18746 19646 114142 26413 76007 26417 56805 21418 21406 21885 245688 15267 319168 319167 22160 319186 16600 319178 319183 319182 20613 319190 319176 319181 228839 99982 93759 228913 20583 14056 93760 319169 67956 625328 78303 319188 15270 433759 13017 13016 15220 15182 624153 382522 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9024446 LXR-mediated signaling 328572 233833 30924 20602 14104 236511 21372 17977 11307 22259 11816 11303 213988 81004 20249 217351 214150 103968 56310 218203 268903 99982 15183 16204 20185 22260 20181 20182 17454 11812 11813 11425 67470 27409 67484 218214 11815 320982 230674 104263 22236 76850 239528 18534 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) 56436 17463 57296 54375 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 18104 59029 67089 70247 18247 18245 18263 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 53814 23997 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) 18053 11848 192662 109904 17136 68585 18377 235402 DISEASES OF THE NEURONAL SYSTEM%REACTOME%R-HSA-9675143.3 Diseases of the neuronal system 242864 77974 79235 14539 19659 12057 22139 19682 11304 19771 20897 19662 NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism 12182 59027 216225 67375 246703 225994 74080 68646 78914 69564 230125 102570 223646 66454 192185 214424 328417 67287 80285 18113 52552 671535 67993 547253 67795 226518 23959 12494 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME DATABASE ID RELEASE 96%9672387 Defective F8 accelerates dissociation of the A2 domain 14069 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle 13836 17973 12549 14270 216963 56513 18481 56324 20742 66894 20779 15239 22284 83669 20844 226652 19229 26431 244895 71228 70584 20403 54126 229658 73341 69581 29875 17974 218581 67300 17920 224105 18708 18709 53382 18479 20740 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 96%77289 Mitochondrial Fatty Acid Beta-Oxidation 171281 74156 13167 223722 329910 70316 11370 11364 67460 11409 13177 93747 15107 20216 18559 66198 264895 110821 66904 17850 73724 109136 66834 97212 11363 231086 26922 171210 70025 71985 52538 72482 78245 102632 75778 56360 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling 12366 12367 18053 12070 22627 18049 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair 232440 74153 20892 70620 17193 269523 234258 71726 382913 18294 72774 18207 66983 240087 71101 71991 12848 26430 100206 100043806 26891 19822 59047 26370 56031 21399 68098 140917 272158 330554 55947 217069 57905 13716 17314 231642 208836 56438 67439 11461 19060 55982 104416 51869 22059 56626 225896 14051 56196 108138 93762 217365 22385 11834 11785 75570 104884 319583 67196 230674 227525 54125 14050 14049 14048 77782 22230 18970 11792 22594 16882 93836 28000 193796 99375 22210 72584 58186 230484 13194 67561 22632 76843 100038882 12566 11545 16881 11350 100039592 50721 28113 101185 12428 319955 57321 56456 22224 19714 244666 71890 26447 319152 56210 77593 68026 56505 216835 68058 21749 225280 497652 26893 21750 56249 69714 227195 109275 26894 68142 11546 13870 108679 233875 70020 19358 19359 235134 26419 22590 12427 22591 107986 26572 22592 50505 26895 268395 69928 18861 17685 268420 17686 69113 17350 69090 17688 75452 20422 77987 26383 14156 667035 13871 22190 66420 69833 67710 245841 69920 107823 20022 68251 14885 20184 209357 66131 66467 269582 20020 232314 231329 70681 20021 70238 69241 27223 56469 66671 19365 17749 56420 100043714 107976 210766 17420 21853 12572 59004 13872 20610 23894 14884 22196 100043429 15267 15204 229615 319168 319167 52864 19360 27015 69745 17535 21975 19363 319186 19364 27354 319178 12021 319183 224008 319182 60530 56791 67513 81601 50883 67030 327762 269400 59001 319190 19361 26754 114714 209334 22427 19687 101831 19090 19718 319176 69263 15574 11920 319181 104806 66979 12189 12190 235610 231724 237911 22596 19355 57434 71885 14375 225182 74335 93765 26909 14087 18538 235559 71711 12144 100040608 381306 237211 68275 106344 72775 72151 211651 18971 14088 68240 60534 18972 233826 252870 19891 18973 319169 18974 80905 19367 19356 19362 67967 268465 12649 78303 319188 15270 624153 382522 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 96%5578997 Defective AHCY causes HMAHCHD 269378 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390648 Muscarinic acetylcholine receptors 12672 12671 213788 243764 12669 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 11491 18183 83961 20779 100042150 11816 667035 22190 20203 17999 20416 107568 13982 13385 13649 22601 18176 14580 19164 20662 19165 15461 100042305 208117 59287 17122 100039623 231821 18667 16396 18708 16765 18706 12991 12223 13874 20850 15200 211323 14402 14401 14400 20185 14394 68652 80707 14407 14406 57249 20692 20315 13645 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 15107 97212 11363 231086 93747 NEUROTRANSMITTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%112311 Neurotransmitter clearance 11423 20518 20517 17161 11669 12846 13162 12038 791260 15567 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 96%3247509 Chromatin modifying enzymes 15161 21427 109115 66233 58523 232440 269424 78656 20602 13626 73247 319149 225895 74026 67155 77766 20586 54351 74195 20588 72341 217031 20587 107435 226976 230233 208146 76804 77853 21761 15077 76901 76719 17692 66310 102162 223527 140858 56790 382207 56397 72195 69612 52615 28019 101206 27878 19646 71777 13486 234366 213464 217127 217588 108946 214162 75565 228714 67773 245688 23808 23942 100683 218214 104263 16452 328572 21372 231051 239985 18600 17977 17978 59035 81004 216185 66993 108143 66464 56310 12753 208043 15183 20185 12914 11909 214899 14534 18599 22289 242726 18602 18601 216848 30841 225876 277250 20174 20591 18676 320595 20592 107932 244694 71371 170787 11461 75605 13435 19712 216825 68094 83796 83797 57376 230674 268936 229542 246103 108155 50724 60406 226830 70315 99982 217864 94246 193796 244349 100041953 71954 107392 667279 238247 15353 18519 77044 12567 12443 269003 233904 83766 75410 69726 208266 232811 239122 54343 11569 213389 17192 66083 77683 52690 18193 14013 20937 192195 75560 93871 73251 225888 64707 84505 234135 235626 70088 110147 56456 56505 99890 216850 93760 66923 67956 18033 64050 381022 19697 107817 27374 70465 107823 67014 71974 621893 214572 319162 15267 319173 319163 319168 66423 319167 13831 319186 319178 319183 319182 81601 228829 319190 338523 319176 18034 319181 66262 70673 116871 116870 78783 14056 319169 15469 18505 78303 319188 15270 433759 319189 624153 15182 382522 SENSORY PERCEPTION OF SOUR TASTE%REACTOME DATABASE ID RELEASE 96%9729555 Sensory perception of sour taste 16518 21906 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins 16993 11687 13077 13076 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358747.4 CTNNB1 S33 mutants aren't phosphorylated 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling 16923 15170 23921 12402 17096 22612 20662 16590 16818 18750 12703 14360 54607 VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.5 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) 102680 FANCONI ANEMIA PATHWAY%REACTOME%R-HSA-6783310.6 Fanconi Anemia Pathway 67513 67030 208836 20892 101831 104806 235610 667035 71885 22190 14087 71711 100040608 237211 13870 68275 72775 211651 14088 140917 272158 60534 68240 330554 55947 19891 50505 268465 69928 67196 52864 230484 67561 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition 54124 56436 20459 17463 17187 75660 57296 20422 26445 26446 12575 19172 19173 211586 19175 13555 19645 19177 21781 21402 12567 26443 12443 11651 26444 12566 11652 19170 12447 66413 26965 667035 27401 22190 12448 59029 12576 19646 67089 70247 66671 17869 17420 12572 12428 13559 104394 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 19651 26441 63955 22390 26442 72568 69077 23797 66997 12530 231506 23997 629959 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 96%9914274 3-methylglutaconic aciduria 11992 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 96%5578998 Defective OPLAH causes OPLAHD 75475 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855191 Synthesis of IPs in the nucleus 75678 27399 76500 69718 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid 67717 12613 69060 18946 109791 18947 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-HSA-2142688.4 Synthesis of 5-eicosatetraenoic acids 17001 14775 625249 11690 14776 18979 11689 330260 269823 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173623 Classical antibody-mediated complement activation 317677 12944 12259 12260 12262 667277 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species 66401 670717 14780 14778 14775 26462 67305 12460 11833 17969 11927 69590 18453 50527 50490 13058 75512 14776 56551 13057 11758 11757 17970 17972 667310 11977 20656 50493 18477 21672 22166 12359 20657 G1 PHASE%REACTOME DATABASE ID RELEASE 96%69236 G1 Phase 54124 20459 12575 211586 13555 19645 21781 21402 12571 12567 12443 12566 12444 12445 13557 12447 242705 26965 667035 27401 22190 12448 12577 12576 100043858 12580 12579 12578 11350 13559 104394 66671 17420 73699 12572 71978 17096 19052 19053 51792 19650 19651 16452 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME%R-HSA-5619048.3 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) 18174 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 96%5579016 Defective UGT1A4 causes hyperbilirubinemia 394433 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 96%199418 Negative regulation of the PI3K AKT network 268980 18183 83961 320207 100042150 20779 17295 11651 11652 22324 18710 14255 26413 26417 14360 327826 13649 21802 73699 19052 19053 228775 51792 30955 18708 18709 18706 226849 108083 225849 74769 18707 26931 12487 21770 12519 26932 12524 12223 71920 13874 15200 211323 77125 19354 12064 14388 15234 17082 18212 18205 78405 11839 13645 80903 384783 14186 14165 83490 18596 14389 77647 16367 18213 14172 80857 16334 14170 14180 14178 14177 67112 64654 14175 14174 14173 14164 83379 17874 16179 19211 13983 266632 13982 18595 244650 98432 15937 12478 75778 18591 56212 16337 18718 19353 14256 19247 22034 104709 13866 18720 18719 18717 16818 16590 23797 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) 24060 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 96%202427 Phosphorylation of CD3 and TCR zeta chains 12500 16818 19271 12501 12502 19264 14969 12504 14968 12988 94212 19260 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 20848 74769 15461 18595 18708 18709 18176 20846 18706 20662 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 96%9956514 ARG1 variants cause hyperargininemia 11846 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.3 Expression of NOTCH2NL genes 50701 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation 394433 12780 15368 14080 26357 17250 15369 11657 109778 233016 28253 394436 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones 110115 94224 13072 13074 15492 78925 15497 13079 16866 15487 100042622 15486 76205 66065 59045 114664 12257 14187 170459 20845 15484 15483 12401 12640 13075 13070 56348 57357 68165 14149 14148 15485 18976 11677 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 96%9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste 18796 20266 546729 387513 399548 20274 110876 20269 72821 387353 240669 387515 353148 68667 14688 353165 387348 14695 268934 16440 56843 64337 83771 574417 14816 387347 57253 57254 110326 387355 83770 387342 387349 242851 387616 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer 18011 232232 13388 16449 240055 225164 20602 11487 54485 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 15213 56233 17869 15214 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 15205 19664 433759 15182 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER 56438 667035 13871 22190 66420 67439 69833 67710 245841 69920 20022 14885 66983 209357 71101 66467 71991 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 23894 14884 11834 27015 69745 59001 319955 19687 19718 69263 66979 56031 21399 18538 28000 13870 68275 106344 72151 18971 68240 18972 252870 22590 19891 18973 18974 22592 50505 67967 57905 99375 72584 13194 REPRODUCTION%REACTOME DATABASE ID RELEASE 96%1474165 Reproduction 232440 12767 319149 14595 12567 12566 15077 94244 21420 12527 20842 22787 329954 71078 213389 28113 11434 22788 101185 22786 16532 106757 225865 24061 74096 73456 12659 320225 56622 76856 19357 75510 11495 212670 271036 71564 12159 57321 319152 21749 497652 21750 244551 12396 13006 18999 100038891 16906 20843 17350 13404 26972 19183 74468 217716 76915 55993 17687 14726 22196 15267 319168 319167 19360 17535 21975 319186 15512 27354 319178 319183 319182 60530 319190 13813 19361 20671 114714 319176 223697 11920 319181 12189 12190 225182 12142 214133 12144 381306 68275 68240 19891 319169 625328 56739 78303 140557 319188 50878 15270 20962 74075 320558 64009 319565 71846 624153 66654 20957 75459 77053 382522 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8941858 Regulation of RUNX3 expression and activity 328572 56436 17463 57296 12400 20422 26445 26446 17246 19172 19173 19175 19177 20779 12399 26443 26444 19170 66413 667035 22190 59029 67089 70247 12578 21762 22123 19179 19181 21803 19182 23996 19184 75788 66313 26440 19166 19167 26441 26442 69077 66997 23997 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 96%198745 Signalling to STAT3 20848 18211 18049 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%2408557 Selenocysteine synthesis 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 214580 20768 57294 211006 20226 65967 75420 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family 213053 214922 227059 30791 106947 72027 14977 106957 67547 72002 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 96%6802948 Signaling by high-kinase activity BRAF mutants 16706 20779 109880 26413 26417 12988 109905 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 11836 109689 216869 110135 99571 22330 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport 193813 12068 54160 317717 56494 60409 89867 11733 235416 11735 216131 107338 67231 66111 640524 66890 20742 20741 54399 20743 217615 338366 80297 234663 224139 21802 213827 11844 53334 68097 67511 53598 56358 14799 56444 67665 104318 22428 56455 13191 12344 59288 105785 11840 64138 235661 18195 108123 108124 76332 16834 110379 11839 13427 102339 13426 13424 99412 338337 17957 67542 16334 66397 97484 69608 233824 218811 99683 56418 70361 77371 20334 66251 56447 54161 77038 12836 56389 59042 56395 69654 228998 68137 67091 20703 11843 66226 19324 66913 105522 243819 14067 69162 14275 12793 12343 67857 12345 100042773 20333 11842 215474 207352 74498 66682 12340 50797 52036 76983 13032 70349 245828 12847 12794 54130 240667 67727 214895 59005 14069 78232 56041 333883 21787 27096 72978 227648 76308 76510 20739 100042343 20740 50907 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN 53627 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME%R-HSA-5632987.2 Defective Mismatch Repair Associated With PMS2 17350 18861 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%391908 Prostanoid ligand receptors 19216 19220 19218 19219 19214 21390 19222 14764 19217 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 96%379401 Clearance of dopamine 17161 12846 13162 791260 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 96%68867 Assembly of the pre-replicative complex 52717 56436 99152 17463 668450 67177 57296 23834 20422 232440 26445 26446 57441 19172 319149 19173 19175 16650 19177 26443 26444 19170 15077 66413 56371 667035 22190 59029 67089 70247 16211 15267 319168 319167 319186 319178 319183 319182 319190 17216 16646 17215 17217 17218 319176 17219 17220 319181 50793 18392 18393 66634 26428 26429 56452 319169 21762 22123 19179 19181 19182 217232 23996 56317 625328 19184 59008 78303 319188 26440 66156 15270 19166 216080 69957 19167 17222 75430 26441 68612 52563 624153 26442 22194 69077 68999 66997 52206 23997 100039535 382522 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation 16193 16451 12534 70686 26395 26396 75590 235584 54721 67603 18218 319520 63953 13537 19252 240672 19247 16194 26413 18611 16452 26417 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 96%5619060 Defective CP causes aceruloplasminemia (ACERULOP) 12870 53945 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%3296197 Hydroxycarboxylic acid-binding receptors 243270 80885 MDK AND PTN IN ALK SIGNALING%REACTOME%R-HSA-9851151.1 MDK and PTN in ALK signaling 19242 19283 17242 11682 PPARA ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-1989781.6 PPARA activates gene expression 20602 23989 59024 18631 327987 70625 68975 14081 234959 94112 28077 70208 12491 20182 20186 171285 13122 11520 56771 50493 228775 80509 67224 19014 229003 11655 11865 66999 328572 11606 394434 21372 11624 109151 11622 11806 17977 73690 19017 18143 13076 17436 17978 59035 81004 66993 24001 69790 56310 12753 26896 15183 20185 217166 107765 12896 12914 56406 108098 76267 14200 18670 15360 66172 170826 192191 14373 26457 78334 94185 14137 100040592 20683 195733 18044 20933 18045 18046 20788 75613 381379 17764 22260 20181 67219 19013 19883 26379 19016 12894 18181 264064 19731 67544 230753 76199 67279 57875 22259 11303 66113 100040843 11807 11364 11863 11864 17979 216154 51813 14080 20859 69792 67381 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 96%72202 Transport of Mature Transcript to Cytoplasm 386612 17149 100040029 20492 19386 170762 108989 231042 227699 223921 227720 445007 269113 66679 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 64340 622469 69912 225027 67996 13684 225160 51796 56488 103468 192160 331401 71713 53817 233073 625193 69823 234865 54451 20382 110809 73666 60365 20383 59015 51786 68278 69736 94230 170722 74320 70579 68188 21681 73826 54188 68134 110379 66231 66511 66899 107829 108014 53319 192170 69207 19826 193116 74412 66441 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism 105663 116914 29807 67283 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 96%5545483 Defective Mismatch Repair Associated With MLH1 17350 18861 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9840310.3 Glycosphingolipid catabolism 54447 11881 14466 244757 18010 23956 58911 20597 11605 271970 11886 17113 67902 14667 545260 11883 19025 19156 50877 74008 20598 77041 77626 58994 14420 70893 15212 238011 15211 230101 12091 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion 14071 DEFECTIVE MPI CAUSES CDG-1B%REACTOME%R-HSA-4043916.4 Defective MPI causes CDG-1b 110119 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME DATABASE ID RELEASE 96%9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex 12952 12914 214162 104318 12753 18626 11865 18627 18143 18628 27373 12953 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 96%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 15107 97212 231086 11364 93747 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975578.5 Reactions specific to the complex N-glycan synthesis pathway 53618 217664 98388 12640 71665 68947 17158 16866 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665348 Signaling by ERBB2 ECD mutants 13866 59079 12539 13649 18176 14388 20662 15461 18803 13645 18708 18706 20416 15519 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 96%5627083 RHO GTPases regulate CFTR trafficking 94221 12638 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 96%4793952 Defective MGAT2 causes CDG-2a 217664 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%70326 Glucose metabolism 18639 14377 18640 170768 14385 18648 56012 15277 70974 15275 56421 18663 67980 14121 14120 74551 18747 14447 224674 19386 231103 73699 216019 14751 19052 19053 51792 170762 108989 231042 227699 100043349 223921 227720 445007 269113 11674 66679 72141 18141 230163 107939 212032 69482 21770 71805 226265 54563 19069 70699 72787 13806 18226 218210 18563 21991 69912 13808 18655 103988 13807 103468 68401 234865 59015 18749 69736 110379 270198 18641 11676 18642 26384 18534 12183 14378 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 96%428542 Regulation of commissural axon pathfinding by SLIT and ROBO 19876 20563 268902 54003 20564 20562 13176 18208 20779 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function 11304 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702577 semaxanib-resistant FLT3 mutants 14255 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9692916 SARS-CoV-1 activates modulates innate immune responses 56532 56480 54131 66824 22031 216799 56489 19697 53902 72512 64685 667035 69550 225913 22190 66101 19035 228005 22034 28185 16211 100039592 268373 20390 71586 230073 66641 108960 18521 14225 228607 217069 12362 18033 170743 18035 16396 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state 93687 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 19206 66413 667035 22190 59029 67089 70247 68525 16568 59056 74239 104346 230500 20747 110355 20423 66313 109689 216869 16396 13363 319757 240888 14632 66573 71742 76857 214498 16147 26554 14451 57810 15245 21762 117606 22123 14634 18222 14633 19179 19181 19182 23996 19184 75788 26440 19166 19167 24069 26441 26442 69077 66997 23997 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%418346 Platelet homeostasis 269717 58802 11937 11938 53313 109305 72413 109552 67972 11941 320707 14697 381290 16531 16533 22065 26416 22068 18126 14710 20866 14699 110891 66066 14700 16438 16439 14708 14706 20541 14704 18125 14695 23984 110893 26946 241489 16440 73699 18783 14693 18436 228139 64337 18574 18440 14709 18573 94045 231602 207728 19052 19053 14701 51792 435726 226849 225849 26931 14702 21770 26932 18613 14696 242202 18127 18585 17540 238055 19222 54195 60596 234889 19247 14688 18438 640703 15170 100163 14191 18439 19092 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance 100017 15450 16835 238055 11816 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation 20602 23989 20933 19697 12567 59024 11450 327987 12445 11819 70625 20788 68975 234959 75613 381379 12224 22410 12606 94112 20181 28077 70208 67219 19013 12491 171285 19016 56771 21926 80509 68910 13591 16846 18139 67224 19014 13654 264064 229003 67544 230753 66999 76199 16600 328572 12609 67279 21372 109151 57875 17977 19017 16956 17978 59035 81004 66993 69790 103968 26896 15183 20185 17979 216154 12914 22408 20528 56406 51813 108098 11770 12608 69792 21803 67381 18033 66172 192191 78334 18534 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function 12021 12189 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%392851 Prostacyclin signalling through prostacyclin receptor 14708 14706 14702 14704 14696 14695 14693 64337 19222 14709 14697 14701 14710 14699 66066 14700 14688 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) 56216 20614 20907 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME%R-HSA-5579009.5 Defective CYP11B2 causes CMO-1 deficiency 13072 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) 16526 72258 16528 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 18970 14156 59001 11792 19687 19718 69263 66979 11545 16881 18538 11546 68275 106344 72151 18971 68240 18972 19891 18973 18974 67967 69745 26430 100206 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME DATABASE ID RELEASE 96%5619097 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) 142681 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9764562 Regulation of CDH1 mRNA translation by microRNAs 233833 213988 17869 236511 217351 17454 12550 214150 76850 239528 18109 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 96%4839726 Chromatin organization 15161 21427 109115 66233 58523 232440 269424 12387 78656 20602 13626 73247 319149 225895 74026 67155 240442 77766 20586 13445 11538 54351 269610 74195 20588 106795 72341 217031 20587 22780 107435 226976 14025 22779 230233 208146 78266 76804 77853 228880 21761 52004 15077 76901 76719 17191 17692 233410 66310 102162 11819 223527 22778 140858 56790 622675 382207 70998 56397 72195 69612 52615 28019 101206 27878 19646 71777 13486 234366 213464 217127 217588 108946 214162 16002 75565 228714 67773 245688 56811 23808 23942 100683 218214 104263 12006 67772 16452 328572 67959 21372 109151 107701 231051 239985 18600 210982 17977 105246 72047 243842 17135 17978 59035 20833 81004 216185 66993 108143 66464 56310 12753 18024 208043 15183 20185 114741 12914 11909 212880 214899 14534 18599 22289 242726 18602 18601 68479 20222 216848 319322 30841 225876 27967 277250 20174 20591 18676 320595 12412 20592 107932 244694 71371 68981 20639 170787 101943 81898 11461 20646 75605 13435 19712 26992 216825 68094 83796 83797 57376 230674 66055 268936 229542 67465 246103 108155 13018 72293 67958 241128 320790 76479 50724 60406 226830 75062 70315 12648 244059 99982 217864 94246 13204 193796 244349 100041953 76938 71954 107392 66125 667279 238247 15353 18519 77044 18534 12567 12443 269003 14121 233904 83766 75410 69726 208266 232811 239122 54343 11569 213389 17192 66083 77683 52690 70802 18193 101631 14013 73503 20937 192195 75560 93871 73251 225888 64707 84505 234135 235626 70088 110147 56456 56505 99890 18104 22026 216850 76246 71389 214498 66317 21413 93760 235497 66923 22083 17927 17928 54624 67956 18033 64050 381022 14377 107686 19697 384091 666609 70127 29861 269397 21423 107817 19708 268996 20641 27374 20638 12055 12054 70465 77045 67332 107823 21406 67014 22196 71974 621893 214572 319162 15267 319173 319163 319168 66423 319167 13831 319186 319178 319183 319182 81601 228829 319190 338523 319176 18034 319181 66262 70673 116871 116870 78783 14056 319169 15469 18505 12417 625328 78303 319188 15270 433759 319189 624153 15182 72057 58208 382522 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) 15275 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m 227697 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 96%3928663 EPHA-mediated growth cone collapse 67268 67938 17904 11848 17880 17096 22612 19877 77579 71960 17886 19878 53972 14360 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects 12571 12567 12578 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome 11810 80287 11811 69865 71281 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 622534 56436 238217 17463 57296 20422 666669 26445 100040021 26446 67025 19172 100043391 19173 668182 19175 241053 19177 432502 56438 19989 26443 76808 26444 19899 100043184 19170 19921 19934 269523 100043755 66413 667035 22190 319195 100043209 68193 59029 621100 19941 67089 665189 666899 70247 100042670 22121 100043876 100043893 100043423 100042986 67281 625646 217365 68172 100042740 19951 667618 100040970 56040 67248 100040331 78913 22230 66855 66244 76788 52231 100041766 68098 67186 67923 21762 22123 65019 19179 19181 19182 23996 19184 26440 19166 216080 672214 19167 71745 26441 100038991 26442 68028 69077 100043000 66997 67891 23997 100043295 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription 20807 19712 14815 56461 CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.8 Cilium Assembly 20873 68121 76260 81896 12534 69940 78887 16570 71769 107338 21821 22628 76411 277939 225745 241950 231123 66482 654470 67590 74360 73242 238799 18536 109181 13196 68259 66296 214552 59030 74201 18541 76568 75786 66061 15519 16568 18747 213081 213575 67161 19889 53869 71909 140810 237222 52028 67378 93730 102774 74025 17997 12879 68097 67978 264134 18005 215445 73738 68475 51792 53598 208518 67694 380718 100041639 67286 236266 20607 78802 106633 244585 12009 99100 103733 319845 22154 74470 104318 56455 101565 110350 16559 16328 219103 18763 18764 260305 76779 16579 83922 71492 245866 216363 26370 76707 13589 18472 232987 21454 12462 13427 22627 13424 27373 12469 12461 12464 64436 18582 227613 68146 22153 22142 212541 22145 12465 100986 319757 12589 19088 56350 77048 230376 69654 52906 17274 18000 73668 67661 75296 53413 75465 15185 72421 72140 106840 67344 67068 219072 11843 20336 56297 225659 107371 72938 53885 207911 76478 320299 329795 78177 16569 217935 27078 28135 214444 76816 74019 217335 54130 105504 74682 211446 72569 18817 71820 381644 102058 109242 67042 233649 73916 12789 382090 232944 231214 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 96%9937383 Mitochondrial ribosome-associated quality control 64658 66419 64660 78523 94061 623346 102060 50529 100040519 68565 99045 66973 69163 52443 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 70316 67681 64655 107733 68537 18100 67707 94066 60441 218506 66230 68463 65111 74600 107734 66242 28028 68735 622268 27398 94067 67840 68836 79044 239555 94065 57312 75398 68572 67308 64659 56282 66292 24030 66121 67851 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling 18211 18803 18049 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 96%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P 21351 SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions 11848 14159 18186 17295 77579 18844 71960 20354 20130 109700 16885 16886 223881 17886 14360 15519 67268 227377 16412 19877 21894 243743 19878 224105 18479 213498 15516 67938 17904 232906 18481 11852 67784 17880 65254 19353 20358 69632 12517 56637 20346 19264 235611 20351 12631 13866 18717 26757 83433 18845 11853 20349 140571 20356 22177 18846 22240 54712 12569 12934 20361 12568 12933 214968 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 320997 CHYLOMICRON REMODELING%REACTOME%R-HSA-8963901.2 Chylomicron remodeling 66113 68453 11806 11813 11814 238055 11807 11808 11816 16956 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%112310 Neurotransmitter release cycle 232333 14412 17161 63993 242607 14411 243616 233977 214084 20508 67760 65106 20518 20517 20513 22343 20511 20510 216456 15481 20512 108030 268860 12647 14660 14415 14417 67111 22348 214579 12361 27204 19339 22318 13002 20614 20965 20979 20964 20907 68507 319924 327814 12889 22249 22342 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation 640703 69219 114886 18127 66427 13430 18777 18108 12389 11651 73178 66394 68268 20751 18107 329416 15519 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen 17330 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 18796 18797 14672 14682 18795 14676 233081 14675 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 18005 12428 12237 107995 12427 56150 21762 22123 19179 19181 19182 217232 23996 56317 12236 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants 16590 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME%R-HSA-9916720.1 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 93747 M PHASE%REACTOME%R-HSA-68886.5 M Phase 20873 52717 68121 99152 668450 12534 232440 78887 78798 319149 22628 225745 231123 15077 74360 238799 18536 66296 214552 26413 18541 116733 59046 244329 13001 59021 13000 382030 100039026 67121 56205 52432 71909 76044 78658 237222 71175 74549 66352 30939 67181 52683 70231 17997 18005 73738 68475 53598 208518 100088 236266 12009 99100 103733 22154 98386 74470 104318 101565 16328 259279 103573 14211 83922 171567 51885 19348 68298 215387 26370 76789 71819 72083 70099 101706 233276 103768 74237 22147 16906 22151 22627 99412 27373 22143 53857 22152 227613 22153 22142 22146 67951 73710 13726 22145 66371 71782 545486 238463 68953 75608 170762 108989 231042 227699 208092 223921 227720 66700 380664 269113 66679 18141 23825 107939 69482 71805 54563 19088 19069 70699 67141 72787 64899 18226 218210 105513 14245 64898 71978 19645 108911 73470 16563 75786 15519 70454 18747 216965 71876 16211 234663 19047 66977 320394 19386 102920 73699 11799 52276 59125 218914 59126 12235 217718 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 19384 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 219103 26951 100710 108000 229841 12237 12617 107995 72415 83815 12615 319152 66570 244495 208628 76707 67139 68014 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 21762 12442 22123 60411 66336 59015 19179 69736 19181 67052 19182 67956 232987 23996 12236 19184 236930 110379 26440 69928 19166 13427 76499 19167 71521 13426 26441 52504 13424 26442 228421 69077 20843 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 18751 59029 67089 70247 22196 15267 671392 319168 319167 100986 319186 319178 319183 319182 319190 230376 319176 69654 319181 75296 219072 19324 225659 381306 76478 22367 71955 78177 64383 319169 224640 74498 319965 105988 28135 50850 214444 100042651 76816 54130 217232 56317 625328 59008 78303 18817 319188 66156 15270 381644 56041 216080 69957 17222 75430 68612 18750 52563 624153 76308 22194 68999 52206 100039535 382522 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975957.3 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 622534 238217 14852 16785 666669 100040021 67025 100043391 326622 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 67031 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 19052 100042740 19951 51792 667618 100040970 267019 56040 67248 100040331 67941 57294 68092 433702 192160 208643 60365 68134 192170 19826 66441 17149 667035 75901 19704 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 233789 71978 65019 103677 629957 226517 20102 74133 229512 20103 71997 668668 667739 14853 672214 66481 225058 100038875 100038991 68028 225363 100043000 67891 100043295 18458 GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly 14623 118454 14618 14609 14619 14621 14615 225152 14610 353155 14613 14617 14612 14611 14622 14620 14616 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%426496 Post-transcriptional silencing by small RNAs 233833 213988 236511 217351 214150 76850 239528 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus 18011 13388 16449 240055 225164 12805 11487 54485 16450 18129 19164 19165 100042305 208117 59287 100039623 17242 667035 76580 22190 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 96%196299 Beta-catenin phosphorylation cascade 225849 93687 26931 21770 26932 12387 14296 73699 72345 212398 19052 19053 51792 56637 12005 11789 226849 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 96%166020 Transfer of LPS from LBP carrier to CD14 12475 16803 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint 52717 99152 668450 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 73804 19053 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 13426 52504 13424 228421 217232 56317 59008 18817 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE 18778 14792 329502 66857 271844 67452 237625 53357 67216 232889 225845 105501 27281 18783 218121 18779 26971 99010 66727 26970 26565 18784 18782 78390 66350 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME%R-HSA-9656249.3 Defective Base Excision Repair Associated with OGG1 18294 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 96%196843 Vitamin B2 (riboflavin) metabolism 319945 52710 54391 18605 11433 69698 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 96%9754706 Atorvastatin ADME 12780 18671 22236 18979 28253 269823 13114 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 96%9938206 Developmental Lineage of Mammary Stem Cells 14165 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 96%8951936 RUNX3 regulates p14-ARF 21803 328572 12400 16653 12399 208727 12443 14312 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance 100017 93835 100102 11806 67963 238055 22259 11816 65969 11771 11772 71770 667035 13909 22190 218203 320024 22359 223920 18145 20652 22260 15450 232910 11773 11812 16835 11425 110611 54135 171504 16889 67300 12757 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%9637628 Modulation by Mtb of host immune system 667035 22190 12010 24088 17533 WAX BIOSYNTHESIS%REACTOME%R-HSA-9640463.3 Wax biosynthesis 245533 67420 245532 330450 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System 17087 12475 22031 19697 106759 16150 18034 14061 16151 17874 12229 434174 21898 20201 20202 266632 117149 53791 12491 21899 20193 12675 14161 18033 58992 16621 170743 18035 12258 24088 21897 54445 110135 142980 99571 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 268980 66899 67561 REGULATION OF TNFR1 SIGNALING%REACTOME%R-HSA-5357905.8 Regulation of TNFR1 signaling 22241 56480 22030 56424 56489 11796 11798 16150 71648 16151 14694 66105 53376 667035 100041766 71609 22190 14082 66552 76686 432940 12675 21937 52440 30941 22029 229603 73218 22258 17164 268749 106025 21926 74256 263876 216080 76580 21929 22195 24105 12370 19766 11797 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%6783984 Glycine degradation 100042811 104174 18293 68133 78920 13382 434437 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 56436 17463 26374 57296 20422 26445 26446 19172 19173 19175 19177 26443 11920 26444 19170 66413 667035 22190 59029 67089 70247 22059 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) 24059 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 96%8953854 Metabolism of RNA 107508 70047 26416 19094 234594 77305 54401 15381 17164 19655 269061 70616 68598 67959 20462 107701 67480 72047 74326 67500 103573 75956 56031 80744 66101 75705 70225 13684 68879 320632 208643 67418 212880 66585 22380 74351 54723 83486 19134 545085 66877 244672 238831 23983 24010 18521 20227 83701 74255 57905 67229 68479 70312 330361 66177 67797 67050 209416 76167 76522 22184 72654 20222 50996 28035 66899 78372 72886 67225 18949 60321 67178 66492 71715 215051 66618 230596 70052 70767 67922 66070 66381 77644 66810 108160 319322 100034361 66801 237859 19205 68592 27967 68035 217207 76936 67471 69757 68988 110532 208768 71702 76793 22668 68981 67684 20639 209003 229279 227707 101943 81898 67439 94315 20646 192159 53317 15382 53379 56258 59013 98758 11991 11834 15388 15387 66055 68816 67197 54633 67465 69192 67285 236732 67958 68183 76479 20624 66642 75062 19704 27366 228005 28000 13204 76265 100041953 76938 68215 66637 233908 74097 66125 68045 73192 104721 68626 117109 68219 66161 98985 381802 228410 66078 54451 28088 108062 67724 67337 67106 83410 98404 18789 51786 94230 74320 68188 55989 15507 19386 218343 56422 68106 69305 319765 140488 19052 51792 445007 57294 69912 103468 66317 234865 59015 69736 110379 107686 384091 666609 216766 66069 621705 20595 66603 53975 12729 276919 68705 20641 98053 27374 13871 20638 22695 66420 56698 69833 70465 67710 69731 245841 432803 69920 67332 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 56417 210106 72181 52575 75619 227682 83485 94254 224481 66132 66410 67390 217038 15108 69821 71989 101122 51810 68017 21379 380601 233789 103677 226517 74133 229512 71997 18750 11651 238799 243963 66053 66983 230594 214290 218693 103135 72587 104625 66362 109075 66583 27998 72544 50911 69639 72662 18983 66446 227715 74108 104318 68092 433702 12192 11810 80287 11811 69865 71281 110109 72026 71701 72085 230734 56335 53621 338359 104444 68291 72068 210529 100043168 70359 232791 27373 24128 108943 328162 233189 240174 76357 74455 229780 66965 108077 209584 68736 30947 13434 100929 54632 68260 73681 68916 66966 28114 66369 67049 57773 17299 100043886 66757 106248 68205 66628 66246 212528 67134 69786 329504 60507 67667 78890 170762 319582 108989 78697 231042 227699 223921 227720 269113 50783 66679 67678 18141 234699 24127 107939 66094 69482 13209 71805 319618 67207 70640 75901 54563 78651 27756 19069 353190 225929 70699 66373 19045 72787 18226 218210 19046 27207 67097 670832 231413 633683 13207 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 71978 27370 65019 629957 20102 20103 668668 14853 667739 54188 672214 66481 225058 100038875 100038991 225363 68028 100043000 67891 18458 100043295 622534 14852 238217 16785 666669 100040021 67025 100043391 326622 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 193740 67031 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 20492 72290 116748 100043876 100043893 100043423 100042986 20115 67281 54196 76846 625646 100040298 68172 100042740 19951 19384 380773 667618 228140 67440 100040970 72416 267019 56040 67248 100040331 67941 69125 56200 72515 67676 27993 102614 50912 67619 66878 58184 217109 110816 68327 64340 66138 622469 229504 225027 15481 208144 67996 98956 225160 22608 67276 51796 67973 56488 18114 192160 18572 331401 78394 71713 53414 53817 216156 233073 269470 625193 59028 69823 12181 20382 21771 21762 110809 75273 22123 73666 215193 60365 64934 20383 67674 217995 19179 68278 73674 19181 170722 67755 19182 70579 68272 23996 21681 213895 19184 73826 76130 68134 216987 26440 66231 66254 19166 66511 66249 107829 353258 19167 108014 56095 53319 71340 26441 192170 224823 69207 102462 26442 19826 69072 69077 193116 76367 213773 66997 74412 105372 23997 66441 67205 386612 72554 56436 17149 104662 17463 100040029 67053 78893 57296 52705 20422 230082 26445 245474 26446 223499 19172 269536 19173 80886 19175 70683 13682 100041622 19177 13681 97961 52846 233802 66164 216578 26443 66181 664817 26444 27966 112403 57750 76014 19170 74035 225432 100608 231464 231386 100040177 67010 66413 234374 240255 68147 70650 667035 30877 216345 22190 75416 74213 57315 214627 52530 59029 14113 68979 67089 208366 227522 70247 14791 57316 67045 54364 72198 65961 622491 68533 18753 170791 20630 14105 20637 53607 70044 56070 67039 15568 72459 11737 56194 69583 100336 671392 52040 140486 72935 13211 56215 22631 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) 11998 54140 26361 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5668541 TNFR2 non-canonical NF-kB pathway 12234 14103 21943 56436 53859 17463 57296 20422 26445 26446 19172 19173 19175 19698 19177 21402 26443 26444 19170 21936 66413 26965 667035 22190 230979 59029 67089 103583 70247 21947 21937 21938 18383 21935 240873 21926 69583 24099 57916 22163 22164 245527 11797 326623 171211 22030 72049 22031 85030 50930 21944 11796 21934 27279 18034 21940 21941 21949 21948 17000 16994 16992 13608 13607 21942 22200 21762 22123 12675 19179 22192 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 96%5690338 Defective ABCC6 causes PXE 27421 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%4419969 Depolymerization of the Nuclear Lamina 382030 12534 14245 16906 224640 18751 64898 13726 18750 67181 380664 64899 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6787450 tRNA modification in the mitochondrion 52575 68291 70359 66966 66132 15108 72026 72085 230734 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 96%3359471 Defective MMAB causes MMA, cblB type 77697 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants 20848 74769 15461 18595 18708 18709 18176 20846 18706 20662 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins 16993 11687 11689 ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling 74244 20779 12322 12323 109880 108058 12325 26413 26417 12988 109905 19047 54401 70686 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 75590 110157 235584 23980 67603 18218 14161 63953 21894 215449 11836 26372 109689 56463 216869 26936 26403 21848 72399 11774 18673 330286 16452 67726 110135 100986 99571 78781 22330 19317 16706 11610 76156 210106 17532 66549 16905 67095 14359 56392 69923 338523 19046 640703 18015 17169 101809 114715 114716 16653 23971 12125 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME%R-HSA-5632928.2 Defective Mismatch Repair Associated With MSH2 17685 17686 17688 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 96%2024096 HS-GAG degradation 15529 11603 23888 15931 20971 20969 15530 14734 27419 15442 103978 27029 71951 20970 14735 14733 545291 15932 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME DATABASE ID RELEASE 96%5619072 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) 22232 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.3 Defective cofactor function of FVIIIa variant 14069 14058 14071 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling 18747 224129 19088 11512 11513 11514 19087 19084 11515 18749 104110 432530 210044 104111 19085 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 96%8984722 Interleukin-35 Signalling 20848 16159 54721 16451 50498 12330 20849 16452 16162 20846 50931 16195 PROTEIN LIPOYLATION%REACTOME%R-HSA-9857492.1 Protein lipoylation 67164 14148 68133 78920 623661 13171 79464 235339 70316 56748 TGFBR1 KD MUTANTS IN CANCER%REACTOME%R-HSA-3656532.4 TGFBR1 KD Mutants in Cancer 21803 21812 21813 17126 17127 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism 75894 76952 18534 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling 12343 19089 13200 434174 11596 12340 20203 20210 11820 26413 26417 16854 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960525 CASP5-mediated substrate cleavage 12367 16176 16173 69146 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-HSA-75876.10 Synthesis of very long-chain fatty acyl-CoAs 56348 26568 54326 257633 433256 83603 50790 15487 328845 74205 57874 68801 30963 170439 106529 54325 66775 12686 94180 14081 216739 74559 243078 70757 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9818025 NFE2L2 regulating TCA cycle genes 15926 18024 17436 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair 22632 70620 11545 16881 66983 71101 71991 12848 100043806 26891 319955 56456 26370 77593 56031 56505 68058 225280 26893 21399 56249 69714 227195 109275 26894 68142 11546 13870 108679 233875 70020 19358 19359 235134 22590 22591 107986 26572 22592 50505 26895 57905 13716 56438 667035 13871 22190 66420 67439 69833 11461 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 56469 66671 17749 100043714 17420 12572 13872 20610 23894 14884 22196 100043429 11834 229615 27015 69745 59001 26754 22594 16882 19687 19718 69263 66979 93765 93836 18538 28000 68275 106344 72151 18971 68240 18972 252870 19891 18973 18974 67967 99375 72584 13194 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription 21415 232440 12387 13626 319149 19697 16478 16842 15077 66310 140858 97064 52615 19646 213464 11910 214162 17869 245688 22601 15251 23808 18109 21679 15267 21676 319168 21678 319167 14281 16362 319186 21677 328572 319178 319183 319182 21414 319190 21416 231051 14282 319176 18034 319181 57261 18024 13819 12914 14056 319169 20846 20848 625328 16476 78303 18033 319188 15270 624153 382522 SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655253 Signaling by FGFR2 in disease 14172 80857 14180 14178 14177 67112 68092 64654 14175 14174 14173 433702 14164 68705 98053 66420 69833 67710 245841 69920 20022 20020 327826 231329 20021 69241 17749 100043714 14183 18176 14388 20662 15461 18803 80903 18708 14165 18706 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 96%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) 20538 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation 14071 14723 14724 54368 14729 109821 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling 14702 14696 76854 19088 20779 19087 19084 104110 14697 14678 14677 14687 14679 14710 432530 14699 210044 66066 104111 14700 14688 18747 14708 14706 14704 16412 14695 224129 11512 14693 11513 11514 64337 11515 14709 18749 16402 14701 242851 19085 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) 70325 239827 327942 55981 66459 18700 67292 72084 13481 110417 433931 230801 18701 668145 67556 27392 56703 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654704 SHC-mediated cascade:FGFR3 15461 14172 80857 14180 80903 64654 14175 18176 20662 14173 14164 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions 13138 60409 14173 244431 192897 13405 20650 16398 13528 13527 20649 16403 24051 20648 20391 22139 24053 24052 16651 268534 20392 15529 11603 20971 16412 20969 16775 16776 16777 21923 16779 16780 226519 16416 16782 16772 23928 20970 16773 16774 21825 22370 18189 18591 109711 15530 16419 12305 18214 22288 16410 21803 57764 12361 13497 18590 18750 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 12914 66494 209456 225655 22059 12177 69076 60599 22061 11920 22062 71361 12028 12122 21981 68428 KW2449-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702569 KW2449-resistant FLT3 mutants 14255 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 96%69231 Cyclin D associated events in G1 54124 20459 12575 211586 13555 19645 21781 21402 12571 12567 12443 12566 12444 12445 13557 12447 242705 26965 667035 27401 22190 12448 12577 12576 100043858 12580 12579 12578 11350 13559 104394 66671 17420 73699 12572 71978 17096 19052 19053 51792 19650 19651 16452 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA 21664 20878 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome 13207 22346 19645 67197 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism 230379 67916 66190 19012 50784 81535 171168 20397 67689 433323 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) 54403 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm 14106 15375 12387 21414 22601 20997 15376 20423 16842 17126 17127 384452 21679 21677 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria 100039786 54401 22628 22631 12015 55948 22629 19058 11651 11652 12122 12043 22627 19057 23797 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963898 Plasma lipoprotein assembly 17777 18747 66397 11812 11806 11813 11814 238055 11425 27801 18453 11816 18749 11303 232345 11807 11808 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 328572 18011 13388 16449 240055 225164 12805 11487 54485 16450 18129 333639 270118 667035 22190 14128 15205 14939 19164 19165 15208 100042305 208117 19664 59287 100039623 17242 76580 103806 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME%R-HSA-174495.3 Synthesis And Processing Of GAG, GAGPOL Polyproteins 73711 22088 67123 330192 667035 22190 66914 18108 107305 72543 194309 52348 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME DATABASE ID RELEASE 96%9682706 Replication of the SARS-CoV-1 genome 13207 22346 19645 67197 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 96%5609974 Defective PGM1 causes CDG1t 72157 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8934593 Regulation of RUNX1 Expression and Activity 233833 12400 236511 17454 18854 20779 12571 12443 12444 12445 213988 217351 214150 19247 76850 239528 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME%R-HSA-5654227.4 Phospholipase C-mediated cascade; FGFR3 14172 80857 18803 14180 80903 64654 14175 14173 14164 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9969896 Lanosterol biosynthesis 20775 319554 17855 110196 14137 192156 100040592 74411 68603 14593 16987 110460 DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME DATABASE ID RELEASE 96%9930449 Defective cleavage of FV variant at a.a.534 14067 19128 19123 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids 77701 26569 225579 11815 26457 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 96%4687000 Defective MPDU1 causes CDG-1f 24070 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 96%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 17161 109731 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME%R-HSA-4720489.4 Defective ALG12 causes CDG-1g TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 96%75944 Transcription from mitochondrial promoters 216151 15278 21780 208595 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress 67013 66839 13665 12034 67204 15467 66592 26905 27377 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway 16451 56208 23989 100038882 59024 327987 70625 68975 234959 15519 15529 94112 23888 13001 20971 16211 13000 28077 70208 100039026 19047 19106 20969 13649 171285 71951 20970 56771 80509 14735 67224 19014 15516 66999 328572 17087 15530 66286 103573 17755 103978 18550 69790 21898 14733 26896 69019 15481 12914 108098 15977 14734 67923 71586 56529 230073 228607 217069 16001 13051 19345 66172 271457 19344 192191 24088 78334 54131 20933 56438 170786 27061 667035 22190 75613 381379 23806 11603 67219 170779 21899 170743 264064 142980 76199 319186 56791 66624 67279 12475 19045 54721 20847 19046 76687 15975 246728 216154 51813 75717 69792 67381 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 96%1247673 Erythrocytes take up oxygen and release carbon dioxide 19743 15129 15122 20533 12346 12349 12351 11826 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 96%112126 ALKBH3 mediated reversal of alkylation damage 69113 69090 75452 77987 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 96%9759774 Diseases of mitochondrial beta oxidation 17850 109136 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression 232440 319149 667501 57230 21429 20019 269003 15077 21340 17191 21339 21341 64424 22130 13871 75316 66420 70333 69833 116848 66136 245841 20017 101867 14885 209357 66467 13436 66671 13433 17749 100043714 17420 12572 13872 23894 14884 93762 15267 319168 20937 319167 319186 319178 319183 319182 319190 319176 21374 319181 50724 60406 93759 94246 20467 100041953 20018 71954 20016 319169 20466 625328 78303 319188 15270 433759 15182 624153 382522 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 96%425397 Transport of vitamins, nucleosides, and related molecules 77701 11739 229782 433923 11740 242585 73836 243328 72621 225579 56327 330064 11416 70484 114304 26569 108652 13340 22232 269346 434203 63959 71279 11815 228368 58246 24060 26457 107566 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 96%9939291 Matriglycan biosynthesis on DAG1 216395 67843 13138 75847 108902 243853 98388 228366 24060 68273 246179 16795 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 96%202430 Translocation of ZAP-70 to Immunological synapse 12500 16818 12501 12502 22637 14969 12504 14968 19260 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 96%5660668 CLEC7A inflammasome pathway 16176 18033 66824 240354 19697 12370 G2 PHASE%REACTOME DATABASE ID RELEASE 96%68911 G2 Phase 13557 12428 12427 13555 12566 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding 12469 12461 14702 12464 14696 14675 24012 19739 50782 14697 50779 14710 14699 66066 14700 67466 14688 13001 14708 13000 14672 14706 100039026 14704 14695 14676 14693 12465 64337 14709 14682 12466 14701 21454 12462 12467 12468 INHIBITION OF MEMBRANE REPAIR%REACTOME DATABASE ID RELEASE 96%9635644 Inhibition of membrane repair 15239 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 12991 11491 18183 83961 100042150 20779 12223 11816 13874 20850 15200 211323 20203 20185 68652 80707 13982 22601 14580 19164 19165 100042305 208117 59287 20692 17122 100039623 231821 20315 18667 16765 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 27413 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 12567 12578 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-HSA-3301854.4 Nuclear Pore Complex (NPC) Disassembly 18141 107939 69482 12534 71805 54563 19069 70699 72787 18226 218210 69912 103468 19386 234865 12442 59125 59126 217718 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166665 Terminal pathway of complement 15139 12759 12274 230558 110382 109828 69379 12279 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells 13836 17395 11487 22612 19353 11771 11772 71770 74325 14360 13848 22325 13846 13845 270190 13842 13840 232910 17390 11773 13841 13839 13838 13837 13637 57257 17096 13636 13643 19164 13642 21844 19165 13641 13640 100042305 13639 13844 208117 13638 59287 100039623 67300 13429 13835 12757 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events 20602 13626 319149 18854 12412 15077 13163 52615 19646 234663 21849 245688 16412 19386 13649 68097 621893 319162 15267 319173 319163 319168 319167 170762 108989 231042 227699 223921 227720 445007 269113 319186 66679 18141 319178 319183 107939 319182 69482 71805 21372 319190 56455 54563 19069 70699 319176 72787 319181 18226 13712 218210 81004 56310 15183 20185 69912 103468 14056 235661 319169 234865 59015 69736 78303 18033 319188 110379 13427 319189 13426 13424 382522 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 96%156588 Glucuronidation 394433 22235 71773 100727 100559 231396 394434 94284 552899 223337 242585 216558 67883 22236 70484 94215 72094 213012 394436 MASITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669924 Masitinib-resistant KIT mutants 16590 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle 242607 233977 67760 65106 14660 20513 19339 22318 20614 20979 68507 20907 327814 12889 20511 22249 20510 216456 20512 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 56316 14071 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-HSA-110320.3 Translesion Synthesis by POLH 68275 106344 22230 72151 68240 19891 80905 19687 19718 69263 217365 244666 269523 667035 22190 68098 18538 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%6787639 GDP-fucose biosynthesis 234730 69064 22122 75540 228368 218138 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation 20963 246256 14131 15162 12502 17096 14129 14360 22612 14191 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism 14874 15233 234724 18478 15445 70266 14085 14204 110391 13180 66514 MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling 11845 19341 12929 12928 260302 19342 14388 15234 17295 LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling 17777 103161 238055 18453 MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation 231413 338359 75619 104444 380773 21379 72416 380601 71701 BIOSYNTHESIS OF MARESINS%REACTOME%R-HSA-9018682.3 Biosynthesis of maresins 13850 13106 72303 13077 11689 56448 13114 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation 70560 67895 71984 224805 353172 70791 68915 230577 226539 71807 107508 20226 69955 244141 107045 226414 97541 216443 22375 234734 107271 27267 105148 23874 231872 70223 66143 15115 110960 66590 22321 71941 70120 381314 104458 67417 102436 74776 85305 109093 212679 13722 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 96%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 66902 68981 16153 19188 56044 11840 12631 50926 667310 66162 18569 12798 18738 268373 11632 20849 12340 18826 53379 17319 18788 12306 98758 15526 20656 21351 14873 215449 21454 16906 667618 224105 17698 12346 15978 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors 17684 21420 21418 18741 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 20873 68121 12534 78887 15366 22628 225745 231123 227613 72119 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 83922 75296 26370 76707 219072 13589 225659 18472 76478 78177 28135 214444 76816 20878 54130 18817 381644 13427 22627 13424 27373 ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects 52717 99152 668450 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 56371 27401 12448 12577 12576 217232 56317 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a 54128 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression 233833 16451 21415 232440 12387 13200 13626 319149 72297 22628 16478 16842 12567 12443 15077 269523 66310 140858 97064 18566 52615 19646 213464 11910 214162 13001 13000 100039026 17869 245688 20747 22601 15251 23808 18109 244373 18005 60533 76580 108099 16362 328572 66357 21414 21416 231051 18024 12914 21762 22123 19179 19181 19182 23996 19184 16476 18033 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 21679 15267 21676 319168 21678 319167 14281 226144 76850 239528 319186 21677 319178 319183 319182 193670 54197 236511 319190 26754 241113 14282 70377 319176 18034 216440 319181 20014 213988 57261 103963 217351 56637 214150 69038 13135 13819 66753 67819 26554 14056 116891 17454 20338 319169 67075 105787 108079 20846 19079 20848 108097 625328 78303 319188 15270 58205 19082 80286 624153 68292 16430 382522 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 96%186797 Signaling by PDGF 74769 20750 17973 20779 20851 12927 20850 18550 107746 14786 20852 12929 19248 12928 18791 19247 12830 12829 12828 12827 18595 12826 18176 18815 20846 20662 218397 12841 20848 15461 21826 12840 17974 21825 18803 245026 12839 71785 18708 18709 21827 18591 12835 21828 18706 12834 18596 12833 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation 14186 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654727 Negative regulation of FGFR2 signaling 14172 80857 14180 14178 12402 14177 67112 24064 64654 17346 14175 14174 14173 14164 109880 667035 22190 19247 26413 26417 327826 19052 19053 51792 80903 14165 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%419812 Calcitonin-like ligand receptors 11535 12310 54598 223780 54409 12311 56089 51801 15874 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling 20779 11651 12927 20963 12928 19395 12988 20416 109905 19419 54519 20662 22371 16399 14083 14268 16416 14161 21894 215449 19246 56508 223864 110135 99571 18607 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane 14069 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME%R-HSA-9629232.3 Defective Base Excision Repair Associated with NEIL3 234258 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 96%4720454 Defective ALG9 causes CDG-1l 102580 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME DATABASE ID RELEASE 96%9664323 FCGR3A-mediated IL10 synthesis 246256 14131 19088 234779 19108 19087 19084 22612 104110 20963 16153 432530 210044 104111 229709 14360 16438 16439 18747 640703 224129 16440 11512 12502 11513 11514 17096 11515 14191 18749 18803 15162 14129 19085 PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-HSA-3215018.5 Processing and activation of SUMO 100043429 75826 223870 320213 56459 50995 20610 22196 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 96%9793242 SUMOylation of nuclear envelope proteins 22196 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events 56208 66383 67443 78610 225326 15530 50528 18186 70008 19645 171283 103978 105513 269523 18550 14733 15529 11603 23888 13207 20971 20969 14734 66371 68953 75608 71951 20970 22346 14735 208092 75669 66700 67197 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling 11848 102098 11491 19697 16150 20663 12367 22324 18759 192656 277360 17874 192662 16179 667035 22190 18049 22325 622434 545156 16443 12015 57257 19164 20662 17207 19165 12366 100042305 16800 208117 59287 100039623 13605 12070 109904 230972 213498 207212 71704 234094 223435 56349 16801 94275 19418 75547 19353 18053 72754 18412 69632 213649 24001 224014 56321 230098 53972 30938 15183 77669 22034 442801 72843 226970 54126 101497 67733 269608 328967 14163 26382 268739 26419 14674 73341 20598 21844 18033 433759 18035 22627 15182 17136 68585 12125 18377 236915 109934 235402 INTERLEUKIN-15 SIGNALING%REACTOME%R-HSA-8983432.5 Interleukin-15 signaling 14389 16451 16169 16168 20663 20662 16453 20851 20848 20850 16185 14784 16186 20416 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes 14381 233833 12866 12865 100041785 22628 11651 11652 19211 333182 216456 17708 17709 17710 100039786 382985 54401 55948 22059 14751 50493 22166 108099 380975 76850 239528 84682 670717 236511 241113 56717 17992 22061 213988 319801 217351 14776 214150 64930 66508 545987 54170 75747 74747 22084 12858 52187 17454 68576 66096 83409 74370 12857 22631 68441 105787 22629 268706 108079 19079 245670 14660 108097 110323 230784 18477 12861 21672 20463 22627 19082 56716 12862 12868 23797 66142 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 96%380287 Centrosome maturation 20873 68121 12534 78887 22628 225745 231123 227613 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 259279 83922 171567 51885 75296 26370 76789 72083 12537 76707 233276 103768 74237 219072 13589 225659 18472 76478 78177 28135 214444 76816 54130 18817 381644 13427 22627 13424 27373 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers 67155 239985 20586 210982 105246 20588 243842 20587 70127 56456 14025 29861 269397 19708 268996 66993 12055 12054 11461 77045 83766 93760 66923 26992 68094 83796 83797 57376 72057 58208 77044 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%212676 Dopamine Neurotransmitter Release Cycle 233977 108030 214084 22343 27204 12361 19339 22318 20965 20614 20964 20979 68507 20907 327814 319924 12889 22249 22342 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels 84036 140493 16531 16534 16533 58802 140492 435726 72413 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses 13823 18213 75409 14811 14810 386750 23859 14814 14813 192167 54525 233067 20910 57267 228836 331461 226352 242667 56376 171180 272381 216856 58234 13385 26558 26557 216028 53310 74342 13383 26556 243961 19024 67533 217692 19268 107065 13169 380785 106025 20168 13822 14251 14816 269587 224997 60367 108071 245537 239250 18189 68507 18190 327814 76965 70530 11784 245450 225875 245446 19280 14252 53623 14799 14802 233977 22343 54526 60510 14812 108030 20980 12361 20979 20907 319924 22342 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717323 ceritinib-resistant ALK mutants 11682 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013422 RHOBTB1 GTPase cycle 26891 51796 56320 12461 26554 20462 69288 242202 19877 15381 106504 109331 12848 17920 22352 19878 56381 19655 53382 12468 100043806 269061 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-HSA-2029480.3 Fcgamma receptor (FCGR) dependent phagocytosis 17913 246256 17973 18806 14131 17909 105855 242687 330319 76884 22612 11308 22324 53357 16885 17886 108100 12928 11461 18754 18805 101314 26413 229709 26417 14360 16438 16439 15519 22325 11350 104759 16440 18753 12502 57257 140579 17096 330662 11465 15162 140580 18708 18709 20430 18479 15516 18706 74769 234779 17918 76709 19353 73178 20963 12229 56443 381925 18807 71910 80987 68089 67771 12631 11867 56378 66713 74117 245880 14191 14083 18016 22376 215280 18803 68524 50884 17925 83767 17882 14129 329165 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9615710 Late endosomal microautophagy 15129 21821 68146 105513 15185 667035 22190 66905 107305 72543 194309 18541 52348 15481 73711 22088 67123 330192 66914 12638 19752 66371 11520 26369 68953 57320 75608 208092 66700 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447038 NrCAM interactions 18187 11733 13385 53310 13383 319504 21367 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 96%192105 Synthesis of bile acids and bile salts 13116 56050 17977 76303 71720 228983 13124 12642 17978 26459 17117 99031 105349 71240 100273 27413 64291 20181 12012 20186 13123 93732 104086 13122 77337 208665 101502 83702 26458 15488 170789 DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) 24060 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 96%5576894 Phase 1 - inactivation of fast Na+ channels 16506 70357 80334 16508 56461 56543 MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion 56417 110532 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9840309 Glycosphingolipid biosynthesis 239559 53897 108105 223753 14344 14343 56336 26879 56386 22234 50935 14421 54218 20444 22239 20454 225742 26938 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11438 110834 110902 11435 11440 108015 108043 11444 110835 231252 APOPTOSIS%REACTOME%R-HSA-109581.6 Apoptosis 12387 12550 211586 13176 13555 22628 20230 21781 11651 11652 227753 74268 72565 66593 26413 26417 16211 54401 55948 12015 12371 19877 12369 68097 14453 11518 13169 18810 21981 22352 56702 50709 14957 18107 50708 14958 17087 80838 209456 72993 56455 13368 13144 13347 69635 97165 13143 107449 94275 107448 56369 22062 21898 12578 26419 21762 22123 19058 19179 19181 19182 23996 19184 26440 19166 16906 12043 19167 22627 26441 12048 26442 11789 69077 12125 66997 23997 14103 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21873 13511 26443 13510 26444 27061 21872 12367 19170 18772 109620 13512 66413 667035 22190 59029 67089 70247 269582 100039786 12261 18753 22059 14939 14102 12368 22035 224105 12370 19766 11797 670717 22030 12475 21933 16646 69146 225471 106759 11798 12018 22061 12028 54722 434174 12122 71609 14082 70415 18761 74143 78514 223255 19057 56215 171543 74006 67013 14272 22631 22629 12169 14083 20848 11783 23797 20740 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer 12539 13649 21802 12402 12223 18176 14388 71920 20662 13874 15461 15200 18803 11839 667035 22190 13645 18708 18706 20416 15519 SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions 14183 DARPP-32 EVENTS%REACTOME%R-HSA-180024.6 DARPP-32 events 18747 21770 640703 19055 19056 19088 19049 73699 19087 19058 19084 19045 18577 110385 18749 238871 19052 19053 51792 12568 19057 19085 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 96%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface 14134 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%R-HSA-3323169.4 Defects in biotin (Btn) metabolism 18563 78038 110821 66904 72039 107476 26363 110948 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida 71078 22788 22786 14595 12659 56622 74468 22787 11495 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME%R-HSA-9958810.1 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) 12385 22325 12388 12387 227377 12550 12552 20779 21844 19353 330662 104836 667035 22190 13040 140580 16480 13030 226970 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) 67103 16993 17001 15446 11684 11690 13850 13106 11687 72303 13077 56448 13076 13114 19225 11689 14865 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037629 Lewis blood group biosynthesis 14347 26878 14348 14345 26877 54218 14422 20443 54613 14344 93961 50935 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand 170743 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 67155 239985 20586 20588 20587 70127 56456 14025 29861 269397 19708 268996 66993 12055 12054 11461 77045 83766 93760 68094 83796 83797 57376 72057 58208 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 96%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 66824 216799 19697 16150 16151 192656 16179 26416 26409 257632 29857 107607 19094 26415 12371 108960 12366 12362 74256 12363 22166 21929 195046 56338 16396 12370 227290 15516 11797 15368 26399 11796 18034 383619 19200 66513 93765 55991 66589 22034 66724 68652 54483 332579 12675 268973 18033 18439 12043 67955 12048 11820 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 96%68882 Mitotic Anaphase 52717 99152 668450 12534 238799 116733 30939 100088 98386 103573 22147 16906 22151 22143 53857 22152 227613 22153 22142 22146 67951 73710 13726 22145 66371 71782 545486 238463 68953 75608 170762 227699 208092 66700 380664 269113 23825 107939 69482 71805 70699 72787 18226 105513 71978 108911 73470 16563 75786 70454 216965 71876 16211 234663 19047 66977 320394 19386 102920 73699 11799 52276 218914 12235 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 19384 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 100710 108000 229841 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 21762 12442 22123 60411 66336 59015 19179 69736 19181 67052 19182 232987 23996 12236 19184 236930 110379 26440 69928 19166 13427 76499 19167 71521 13426 26441 52504 13424 26442 228421 69077 20843 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 22196 22367 71955 64383 224640 319965 105988 50850 100042651 217232 56317 59008 18817 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 96%5627123 RHO GTPases activate PAKs 67268 67938 640703 17904 107589 18481 17880 13043 77579 19353 71960 18016 16885 17886 19046 224105 329251 17931 192176 18479 RHOBTB3 ATPASE CYCLE%REACTOME%R-HSA-9706019.5 RHOBTB3 ATPase cycle 26554 12447 56382 319642 66905 22346 230654 73296 15239 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 80857 18803 14180 14177 67112 64654 14175 14174 14165 14173 14164 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 96%1482798 Acyl chain remodeling of CL 53357 66826 225010 18783 97212 231086 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 96%1169410 Antiviral mechanism by IFN-stimulated genes 16451 56208 12534 17973 74153 20892 19043 100038882 193740 17999 26417 19255 16211 100039592 16648 19106 100037258 19386 73699 55948 19052 11465 19053 381686 51792 16649 445007 226849 66892 26399 18550 24015 69912 15481 13684 103468 208643 234865 230073 12675 228607 59015 217069 69736 13690 110379 18803 69928 192170 14469 54131 13682 13681 16150 23992 21357 16151 18148 667035 22190 11461 24110 23806 55932 66369 22059 23960 225467 67781 22196 246727 12362 56417 231655 20698 170762 13665 286940 108989 67204 231042 227699 223921 26905 192176 230861 211948 227720 15512 269113 15482 66679 18141 107939 56791 67513 69482 23988 67030 71805 16201 112419 54563 16646 19069 101831 24014 70699 72787 18226 104806 218210 18712 20617 13211 71885 93765 14087 100040608 246728 237211 110606 72775 229898 14088 14272 60534 20846 20848 22194 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 96%71288 Creatine metabolism 240332 76722 102857 12715 14431 12709 67092 14411 243616 12716 ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%8939211 ESR-mediated signaling 22632 233833 232440 319149 268980 20779 16478 12443 11651 12389 11652 15077 18710 12005 12576 26413 26417 15519 100039592 17869 13649 21802 18176 20842 15461 24061 19014 18708 18709 15516 19357 18706 18607 328572 12400 17395 17392 18127 17977 12223 16589 14462 21374 71920 103573 13874 13712 17978 15200 59035 268903 107951 13006 12914 235459 11909 640703 83602 12455 56484 16001 16476 11839 12043 13645 17863 20843 18762 20683 14732 14697 68705 13610 98053 66420 69833 14710 67710 14699 245841 13983 66066 69920 14700 20022 20020 14708 231329 14706 20021 69241 14704 13982 17749 100043714 14695 19060 14693 64337 14709 15267 14701 319168 18667 20698 319167 14281 76850 239528 319186 319178 12705 319183 14702 20807 319182 81601 14696 236511 319190 14282 319176 319181 213988 14678 14677 14229 217351 214150 67393 12648 14679 13033 99982 14228 18986 17979 193796 14688 228913 13207 21887 15375 55960 268527 17390 107351 17454 26424 21786 15469 319169 22282 22278 18519 100041004 100043508 14083 625328 78303 319188 68268 15270 433759 12390 20315 17393 102193 67738 624153 71393 23797 242851 382522 P75NTR SIGNALS VIA NF-KB%REACTOME%R-HSA-193639.3 p75NTR signals via NF-kB 19697 16150 18759 192656 18053 17874 18412 18033 16179 667035 18035 22190 18049 22034 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 96%379398 Enzymatic degradation of Dopamine by monoamine oxidase 17161 12846 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects 12578 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 96%5626467 RHO GTPases activate IQGAPs 19353 12385 544963 640703 12387 12550 56430 17283 404710 29875 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression 19052 67121 12534 56205 19053 52432 51792 73699 59046 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111448 Activation of NOXA and translocation to mitochondria 211586 13555 22059 21781 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669934 Sunitinib-resistant KIT mutants 16590 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 96%8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 17869 12575 21420 75605 21418 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622323 Presynaptic nicotinic acetylcholine receptors 11438 110834 11449 110902 11435 11448 11447 11440 108015 108043 11444 110835 SIGNALING BY AXIN MUTANTS%REACTOME%R-HSA-4839735.5 Signaling by AXIN mutants 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948001 CASP4 inflammasome assembly 640703 66222 12363 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 96%3359473 Defective MMADHC causes MMAHCD 109129 67096 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 96%1638091 Heparan sulfate heparin (HS-GAG) metabolism 15931 14043 14042 15531 15530 27419 103978 54710 628779 54616 58193 50785 14733 545291 70484 83398 50786 23908 15529 11603 23888 20971 93683 20969 14734 64580 15476 15442 15478 27029 195646 71951 17423 20970 328779 14735 50787 319415 15932 CYTOPROTECTION BY HMOX1%REACTOME%R-HSA-9707564.6 Cytoprotection by HMOX1 20459 12866 12865 100041785 20602 216799 17250 333182 17708 17709 20181 17710 19013 56338 19014 380975 229003 84682 670717 15129 15368 15122 12013 21372 109151 17977 17992 17135 17978 59035 14950 81004 66993 18024 15369 11657 15183 20185 109778 233016 106766 12914 56406 12858 14080 12857 20466 20848 110323 12861 20463 12862 12868 66142 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis 56532 74568 22030 71609 14082 12370 19766 PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%1257604 PI3K AKT Signaling 233833 13626 268980 18183 83961 320207 100042150 20779 17295 11651 11652 22324 18710 52615 17999 19646 234366 26413 26417 14360 327826 13001 13000 100039026 56233 245688 13649 21802 23942 78757 228775 30955 18708 18709 18706 108083 18607 74769 18707 12487 12519 12524 19354 15183 66508 545987 54170 11909 22084 52187 68576 66096 83409 74370 68441 268706 15234 67605 245670 56484 16476 83490 18596 216848 77647 18213 107932 19211 19712 18595 22059 229542 20613 56424 56212 11798 18718 99982 217864 13866 18720 18719 15370 20393 12575 18854 66894 72607 68031 73162 19720 21951 74493 14302 12576 14255 21907 73699 12015 12371 12418 19052 17192 19053 51792 14013 12151 226849 225849 26931 19763 21770 26932 17246 54383 13619 12223 241915 12416 71920 13874 15200 211323 19821 77125 494448 21762 30951 22123 12064 12675 14388 17082 19179 19181 18212 19182 23996 18205 19184 78405 99377 26440 19166 11839 19167 13645 26441 80903 384783 26442 69077 14186 66997 14165 23997 14389 56436 16367 17463 14172 57296 80857 20422 26445 16334 14170 26446 19172 14180 19173 14178 19175 56458 14177 67112 19177 64654 14175 14174 26443 14173 26444 14164 83379 19170 17874 66413 16179 667035 22190 59029 13983 67089 70247 266632 13982 19016 244650 13498 68877 98432 58988 15937 12478 75778 76850 239528 18591 54601 236511 56717 16337 13653 19353 213988 217351 56637 14256 214150 227743 15184 19247 22034 116871 116870 104709 20583 14056 18717 17454 252870 109270 606496 433759 16818 16590 56716 15182 23797 54484 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 96%983705 B Cell Activation 12234 269717 56436 17463 57296 17973 20422 26445 26446 58194 19172 19173 19175 109305 19697 19177 21402 16150 26443 26444 12483 16151 22324 19170 19696 22063 12042 66413 26965 667035 22190 18751 240354 20866 59029 26409 67089 229709 103583 14360 16438 70247 16439 16440 17096 18176 20662 15461 26377 12478 18708 18707 12143 234779 20963 12229 17060 12518 15985 640703 15170 268373 19055 19056 19419 18018 18019 21762 240168 22123 19058 12675 14225 108723 18021 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 18037 26442 69077 66997 83490 23997 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA 233833 232440 319149 94223 192119 23992 53424 21357 22099 15077 66420 69833 67710 245841 69920 74068 20022 210510 74691 15519 57746 20020 98558 231329 83456 20021 330890 69241 72634 71981 17749 13206 100043714 17864 66715 94244 57749 83561 15267 319168 319167 19384 76850 239528 319186 319178 319183 319182 236511 319190 319176 319181 213988 217351 214150 320727 11727 68626 319169 75284 72322 625328 14000 78303 319188 15270 624153 382522 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 12539 13649 12402 18176 14388 20662 15461 18803 667035 22190 13645 18708 18706 20416 15519 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190242 FGFR1 ligand binding and activation 21814 80857 67903 14180 14177 67112 64654 14175 14174 14165 14173 14164 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 96%69563 p53-Dependent G1 DNA Damage Response 56436 17463 57296 20422 26445 26446 12575 19172 19173 19175 19177 26443 26444 12566 19170 12447 66413 667035 22190 12448 59029 12576 67089 70247 22059 17248 29813 59092 26374 50883 228829 12428 17246 11920 12578 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis 17364 233833 18992 236511 17454 192119 15254 20466 12047 213988 217351 433759 12043 214150 329581 76850 239528 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 96%916853 Degradation of GABA 214579 268860 STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 96%2672351 Stimuli-sensing channels 14226 20393 65973 76757 109552 225997 22063 193034 22065 22067 667035 22066 22190 28240 20192 22068 20191 63873 171382 69847 171166 20190 75607 56407 279561 68667 208169 277328 64177 17364 107568 382427 246788 27219 68279 94178 22368 226025 101772 194352 117160 26946 56843 170755 58800 14628 241118 11419 110157 212989 102566 404545 229277 338370 26372 140475 13830 105722 382014 14605 20278 78339 217843 320091 252972 20276 20277 232341 56365 233246 26373 12728 12727 83814 12725 12724 97086 12723 243634 23844 74446 24115 58170 99663 233979 229933 12733 105355 640703 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 96%1839120 Signaling by FGFR1 amplification mutants PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling 16891 270669 30924 68453 103161 11806 57875 11307 238055 105847 18453 11816 16956 18552 18550 66113 18553 11657 11807 11808 16816 56453 17777 56636 624219 15450 76483 11813 11814 208677 ANTIMICROBIAL PEPTIDES%REACTOME DATABASE ID RELEASE 96%6803157 Antimicrobial peptides 19152 246082 654460 654465 244332 629114 12796 18173 66557 11870 22072 11977 21946 12504 19695 12772 17002 18489 12652 16429 18843 19194 329547 12458 12759 54159 78416 228801 57757 242100 11927 50701 72621 259301 228796 75526 384997 20201 20202 13035 77674 16819 24088 654464 21897 266620 654459 75400 246700 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 96%4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 225849 93687 26931 21770 26932 12387 14367 72345 14362 57265 12389 22416 56637 12005 22423 20890 22408 103236 13542 14296 73699 13544 13543 212398 19052 19053 51792 16974 11789 16973 226849 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 96%111471 Apoptotic factor-mediated response 670717 12261 69146 12371 11798 12018 12369 56369 12367 11783 12028 54722 74268 72565 66593 26413 26417 12578 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 96%174417 Telomere C-strand (Lagging Strand) Synthesis 327762 14156 214987 214901 68964 72107 22427 108689 19687 57321 69535 19718 69263 21749 16881 497652 21750 18538 12144 68275 18969 106344 18968 72151 18971 68240 18972 19075 19076 19891 67967 28113 101185 69745 SARS-COV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%9678108 SARS-CoV-1 Infection 20448 56208 16785 19089 67443 78610 66824 216799 22628 19645 12389 269523 12330 100039316 16211 100039592 54401 55948 20115 17127 17128 76846 100040298 267019 67941 18607 328572 57294 50528 70008 69550 66101 19035 28185 268373 71586 230073 66641 18521 14225 228607 217069 56217 18033 18035 22627 12048 75669 56480 20683 54131 225326 19697 18148 667035 225913 22190 67089 100039786 20390 15382 66371 108960 22196 68953 75608 12362 170743 16396 208092 66700 67197 56532 22031 56489 53902 105513 72512 64685 56637 228005 22034 27207 67097 670832 633683 13207 20044 27050 667279 20085 668144 20084 382492 20055 22631 75617 57377 27370 22629 629957 20102 14423 20103 214424 668668 328417 667739 606496 67287 80285 52552 20446 671535 20444 22346 66481 547253 20442 225058 20443 100038875 17308 20440 14376 20447 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 96%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 100039786 22627 54401 22628 22631 55948 22629 23797 12389 11651 11652 18607 DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 96%4724325 Defective ALG8 causes CDG-1h 381903 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 96%72203 Processing of Capped Intron-Containing Pre-mRNA 66053 66983 15381 19655 70616 269061 68598 67959 20462 107701 67480 72047 68092 74326 67500 433702 75956 56031 80744 66101 70225 13684 68879 320632 67418 212880 66585 22380 74351 54723 83486 19134 545085 66877 244672 238831 23983 24010 18521 20227 83701 74255 57905 67229 68479 56335 70312 330361 66177 67797 67050 209416 76167 210529 76522 22184 100043168 72654 20222 50996 66899 28035 78372 72886 67225 18949 60321 67178 66492 71715 215051 66618 230596 70052 70767 67922 66070 66381 77644 66810 108160 319322 100034361 66801 237859 19205 68592 27967 68035 217207 76936 67471 69757 24128 68988 208768 71702 76793 22668 68981 67684 20639 209003 229279 227707 101943 81898 67439 94315 20646 192159 53317 15382 53379 56258 59013 98758 11991 11834 15388 15387 66055 170762 108989 231042 68816 227699 223921 227720 269113 50783 67197 66679 67678 18141 54633 107939 66094 67465 69482 71805 69192 54563 78651 27756 19069 67285 70699 66373 236732 19045 72787 67958 18226 68183 218210 76479 20624 66642 19046 75062 27366 228005 28000 13204 100041953 76938 13207 233908 66125 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 74320 68188 54188 20492 19386 54196 445007 64340 622469 69912 225027 15481 67996 225160 22608 51796 56488 103468 192160 331401 71713 53817 233073 625193 69823 234865 20382 110809 73666 60365 20383 59015 68278 69736 170722 70579 21681 73826 68134 110379 66231 66511 107829 108014 53319 192170 69207 19826 193116 74412 66441 386612 17149 100040029 107686 384091 666609 216578 100040177 67010 68705 20641 98053 667035 20638 22190 66420 69833 67710 245841 69920 67332 20022 20020 231329 20021 72198 69241 17749 100043714 170791 20630 14105 20637 53607 70044 56070 67039 72459 56194 100336 52040 72935 13211 56215 51810 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037628 Rhesus blood group biosynthesis 19746 DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 96%9734735 Defective ADA disrupts (deoxy)adenosine deamination 11486 ICOS CO-STIMULATION%REACTOME%R-HSA-9927354.2 ICOS co-stimulation 104709 74769 18707 18710 30955 50723 320207 18708 18709 18706 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 96%2033519 Activated point mutants of FGFR2 14172 80857 14180 14178 14177 67112 64654 14175 14183 14174 14173 14164 80903 14165 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 96%9665251 Resistance of ERBB2 KD mutants to lapatinib 13866 59079 12539 15519 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%3769402 Deactivation of the beta-catenin transactivating complex 12234 20679 21415 20682 12387 21414 21416 20671 17283 20674 16842 11798 11651 103573 11652 66310 140858 667035 22190 213464 20668 21885 21887 20680 75410 21886 22631 21888 23808 20675 20677 433759 77578 68911 13016 67772 67087 80288 11789 73739 72135 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex 68092 433702 20922 68705 98053 13871 66420 69833 67655 67710 245841 69920 57314 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 58202 17420 12572 13872 27632 20924 24116 23894 14884 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT 16590 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72306 tRNA processing 107508 70047 19386 19384 445007 67676 102614 69912 103468 234865 72026 72085 67674 59015 230734 69736 68291 110379 70359 76367 67053 108943 328162 233189 240174 76357 74455 208366 229780 227522 66965 209584 68736 30947 54364 13434 100929 54632 68260 73681 68916 66966 28114 66369 67049 57773 17299 100043886 66757 106248 68205 66628 66246 212528 69786 329504 60507 67667 170762 78890 108989 319582 231042 78697 227699 223921 227720 269113 66679 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 52575 66132 15108 76265 68215 66637 74097 68045 73192 104721 68626 117109 98985 66161 381802 66078 108062 28088 67724 67106 98404 94230 54188 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs 11684 11687 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559580 Oxidative Stress Induced Senescence 233833 232440 13626 319149 211586 13555 21781 12571 12567 15077 13557 242705 667035 26416 22190 52615 19646 26413 26417 19094 245688 102626 22059 12418 665113 17164 15267 319168 22166 319167 14281 76850 12151 319186 26408 17248 319178 319183 17165 19763 319182 236511 17246 319190 54383 13619 26399 26400 319176 241915 12416 26398 319181 26420 26414 213988 26397 217351 19821 214150 100043858 12580 216850 12579 12578 14056 50932 26921 494448 17454 15977 26419 319169 30951 625328 16476 78303 319188 15270 624153 382522 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 96%418359 Reduction of cytosolic Ca++ levels 11941 320707 381290 640703 20541 11937 11938 110893 53313 110891 109552 67972 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 96%391906 Leukotriene receptors 574402 58861 16995 57260 70086 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 96%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 56208 225326 66397 12317 14827 69608 15006 80898 218811 99683 240095 667803 12330 21354 21356 21355 14991 77371 69162 20334 110379 14828 15007 12010 218978 75669 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ 19300 68421 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME%R-HSA-5658034.4 HHAT G278V doesn't palmitoylate Hh-Np 16147 226861 20423 13363 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209952 Peptide hormone biosynthesis 16326 22094 18976 16325 12640 16324 18548 16323 16866 16322 14308 DAP12 SIGNALING%REACTOME%R-HSA-2424491.4 DAP12 signaling 22325 74769 16643 83433 234779 57257 18176 20662 22177 19353 15461 20963 17444 667803 12229 18803 16818 12010 18708 16822 18709 14360 27007 18706 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190375 FGFR2c ligand binding and activation 14172 80857 14180 14177 80903 64654 14175 14173 14164 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 96%194068 Bile acid and bile salt metabolism 76408 13116 56050 17977 76303 20494 71720 20493 228983 106407 13124 12642 330962 17978 26459 170460 17117 99031 105349 71240 100273 27413 11657 16204 28250 64291 20181 12012 20186 13123 93732 104086 13122 77337 208665 101502 28253 83702 26458 15488 170789 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 96%1912422 Pre-NOTCH Expression and Processing 233833 232440 11937 11938 319149 211586 14595 53313 18129 13555 18131 18128 21781 18132 12443 270118 18759 15077 13557 50721 13710 54613 22059 15267 319168 319167 76850 103806 239528 319186 328572 319178 319183 319182 236511 319190 333639 319176 50701 319181 213988 18550 217351 214150 12914 17454 14534 20338 319169 18519 16848 625328 19664 16476 78303 319188 15270 19719 17305 19346 20443 224143 140484 624153 100042343 382522 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade 14919 18108 107477 14913 245650 73582 14685 20215 12788 212541 14699 18761 75624 14688 110606 640703 14272 24013 56307 237178 243923 225600 18750 18107 18587 18588 19674 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle 23825 268373 14156 12767 16646 15361 101739 12504 108138 319583 22596 16881 14375 12774 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME%R-HSA-162589.3 Reverse Transcription of HIV RNA 268373 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 96%3656225 Defective CHST6 causes MCDC1 18295 16545 14264 56773 116847 17022 27047 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 18039 14810 11472 19417 23859 19418 14814 12322 12323 108058 12325 26413 26417 20111 640703 13385 53310 13383 110651 14812 18176 20112 15461 67071 18607 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%1592230 Mitochondrial biogenesis 216151 15161 12326 381760 26416 29857 20181 19013 19094 26379 108099 18181 14390 19014 68346 229003 11655 14661 226169 670717 15278 21780 21372 109151 241113 17977 19017 60525 17978 59035 81004 66993 17260 17261 224481 208595 70461 15183 227112 20185 17827 57423 217166 68653 74343 66477 12914 76614 382056 224904 56406 11958 11909 640703 11957 68117 230935 216821 11947 66075 11949 433771 68055 75387 108079 68316 17705 19079 11946 15526 269951 20656 108097 66098 66043 11950 53375 100041835 100039108 170826 432676 19082 64384 228033 226153 50776 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 96%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) 317750 PI3K CASCADE%REACTOME DATABASE ID RELEASE 96%109704 PI3K Cascade 14389 74769 16367 14172 80857 18576 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 327826 14388 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 18607 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 96%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 19303 16412 57342 16202 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%192814 vRNA Synthesis 11545 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME%R-HSA-5579032.4 Defective TBXAS1 causes GHDD 21391 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling 20437 19876 68799 226251 17973 20563 223435 17909 13176 107449 20779 107448 319713 19353 73178 22063 22065 22067 69585 22066 210801 20564 22068 20562 114873 22350 19247 18761 216439 244058 18738 26946 22253 18007 14083 330662 231148 57764 18803 13508 18208 20439 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME%R-HSA-1362300.3 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 13559 75660 104394 12534 12428 211586 13555 21781 433759 19650 19651 19646 17865 72568 231506 629959 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-HSA-2470946.2 Cohesin Loading onto Chromatin 71175 71521 24061 74549 100710 218914 20843 19357 13006 20842 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions 20536 20535 13521 55961 216225 208890 114479 320718 74340 232156 20515 20504 57138 54403 59033 20498 243755 20499 20495 20497 20496 107723 23985 13487 94229 240215 20516 171429 20533 268512 218756 20505 231583 142681 20531 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events 18796 18797 14686 18795 12326 20779 19084 26413 212108 242093 239336 23919 14419 12772 12774 12768 80901 84112 20607 387512 12776 12775 12458 12773 12771 18386 18389 14539 243270 239283 387513 14427 18166 19218 18167 18168 14294 12802 14293 12801 387353 387515 353148 12765 227288 56838 57811 17773 244701 640703 353165 387348 19055 387356 19056 19156 20605 19065 20606 19064 19058 80885 12145 20609 20608 14428 13051 217212 208990 110326 12568 83770 11820 20132 140795 57349 30878 17329 20290 18155 55985 20303 109648 20304 12057 14675 20296 15557 24012 19739 57385 13491 13490 20297 100039973 50782 74191 100038965 14697 13610 56066 12672 50779 20311 20312 15552 20300 14710 11539 15551 14699 66066 18610 243764 14700 18619 11542 14708 66102 14706 14672 13611 51791 15563 330122 14704 14823 67839 225192 108073 14695 268934 14676 94226 19049 108069 67792 108068 58175 14693 20310 18545 14825 64337 353344 18577 14709 14429 110385 14764 238871 13603 11609 14682 23796 83771 67865 14701 574417 71729 387347 57253 12777 57254 387355 387342 626596 387349 12766 226304 76123 387616 321019 12778 14702 381073 106512 110168 14696 436440 76854 12769 19088 15199 14763 19108 70839 19045 12267 171469 104110 227326 14739 14678 12854 14677 16952 15945 14687 14679 432530 210044 104111 19057 14688 224129 11512 11513 11514 11515 18749 20315 242851 19085 12767 19087 53978 12322 12323 108058 624910 12325 246709 19734 229709 16438 16439 18798 18747 100039592 14745 16440 73699 56183 19052 64214 19053 51792 14289 12374 50778 56744 50780 19736 11606 21770 12061 12062 14680 56470 216749 19737 55984 65086 54393 240816 381810 574402 385643 433292 207565 110312 18752 11551 14767 11552 11553 56533 242425 14685 18387 18390 212541 20210 15139 12266 18753 18783 110355 18575 18574 18573 12273 20604 207911 18976 18750 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription 13207 22346 19645 67197 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 96%3296469 Defects in cobalamin (B12) metabolism 93835 17850 54219 109136 68421 238505 65969 21452 77697 210009 109129 67096 14603 19300 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%8937144 Aryl hydrocarbon receptor signalling 11624 11632 11622 11863 100043508 15516 11864 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%376172 DSCAM interactions 13508 13176 114873 18208 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME%R-HSA-9956520.1 ASS1 variants cause citrullinemia 11898 67824 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions 24059 11998 227394 58807 108115 101488 20502 28250 28253 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 96%445144 Signal transduction by L1 22325 13001 13000 100039026 16412 13649 18186 26395 26396 16410 16399 19353 16416 16402 16728 17967 26413 18479 104099 26417 FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 96%9769733 Fibrin formation 19123 11905 14060 15160 16399 14061 20720 268591 16416 14161 110135 99571 74145 HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis 20779 12389 14786 26416 12928 18754 18126 18755 320127 26413 76192 18787 26417 239273 104418 56077 20416 66082 22325 231871 380921 109905 110524 269060 110197 217480 13139 331374 57257 54519 18176 20662 22371 15461 16416 110157 14161 21894 215449 109689 216869 16452 110135 99571 22330 15129 109711 242202 11806 54216 56760 11852 238055 17135 22365 21390 14673 640703 268373 19419 14674 20501 12215 15234 22041 210293 12568 63955 11820 22390 13449 26934 14697 14710 14699 66066 14700 14708 14706 14704 14695 14693 64337 14709 14701 14702 17075 14696 16363 21933 19088 234779 20963 14678 14677 232345 14679 11657 217864 14688 18438 68117 15353 17319 18788 14191 18749 18439 67414 170731 242851 67299 19085 269717 11931 11932 11933 11937 11938 53313 109305 18793 109552 12566 67972 11941 320707 381290 16531 16533 20866 110891 16331 16438 73470 16439 16563 18747 15529 23888 11640 20971 217837 20541 12491 18125 110893 20969 16440 73699 18436 228139 18440 12527 94045 231602 19052 71951 73804 20970 19053 51792 14735 12505 76088 226849 225849 26931 21770 26932 15530 229841 18693 103978 17134 14733 667310 57274 15977 21912 80879 14734 208869 78287 18752 18803 17289 14828 19128 13645 14456 228421 19152 16069 240641 269152 16565 16564 16552 16580 16581 16561 13660 16562 68732 108829 16558 20399 70218 56697 15135 75050 252966 16554 17133 286942 15132 11603 56248 16578 259300 319991 57440 171580 16560 14464 16409 83964 16423 16411 16414 67374 105722 11674 53896 14465 30962 233246 19353 50934 19247 104709 20540 330836 15170 17254 16569 20539 26570 625328 16818 18750 17136 19092 14066 16570 217847 319149 320207 11472 19084 22612 15160 11651 22324 15077 20194 18710 20725 20719 18791 18792 20737 66053 12419 14360 12988 16568 16002 16000 14723 17096 16784 21825 16362 30955 18708 18709 18706 18607 74769 18127 14462 19222 16594 668303 16579 14461 232943 14460 19348 14463 71819 16593 16551 110033 19354 16149 209737 74764 19156 19123 100163 22363 12481 271457 20339 69524 19261 108078 17863 12523 22364 20343 72017 20345 57349 13052 20340 64435 270152 71683 16456 12506 18762 16923 58217 11848 171486 58802 18106 23921 14675 11905 72413 68813 14672 16572 16573 16412 23984 241489 14676 22145 22059 94176 330662 207728 14682 19246 238130 14724 268936 192176 435726 54368 14729 56212 23945 54195 70839 60596 234889 99982 20909 12343 12345 12340 21857 12306 16410 16571 14083 21803 21808 16728 22761 21809 74947 279028 19087 12331 18643 213119 11350 18441 58992 16621 56744 14064 14062 22762 14061 83995 14065 385643 11551 11552 11553 16822 16797 75974 14068 319899 109700 22065 16398 16400 16403 14058 18751 22068 14071 66901 16408 106722 26946 14127 243816 18753 14726 18783 18574 18573 16399 14268 16401 16402 11818 27359 12258 21346 56508 223864 20716 227290 19363 18591 18022 117586 109232 21687 71946 11600 12759 215789 235505 67988 11537 12321 18613 26968 68038 114714 20912 20911 18585 21922 17540 20255 108101 21824 218454 14060 223601 109821 12512 20720 12927 268591 80718 19124 16426 20597 22138 68891 227612 60595 104009 320202 70945 53612 67059 18761 20703 11625 21767 19395 19073 56541 74145 14067 12631 14205 11601 21832 50915 17480 11602 80884 20344 21859 74840 94175 13041 22631 20363 11747 16427 18815 56193 18816 20466 19039 56055 13601 240334 14069 20692 433759 22388 75396 22341 18407 22339 22340 11804 71660 15182 67072 66866 27999 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME%R-HSA-4085011.4 Defective GNE causes sialuria, NK and IBM2 50798 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress 52717 99152 668450 56494 15901 67443 20602 20867 26416 26413 26417 20416 19094 102626 17164 11518 21894 71853 20818 107513 68090 78943 19014 77128 229003 26427 11865 208647 19377 15516 381801 70804 27362 52466 27053 328572 12915 15129 320209 17087 78284 15368 64209 15122 22393 12013 15191 56444 21372 52639 67665 109151 72599 22428 11806 13191 56760 192193 17977 74322 12344 238055 12611 19017 71765 59288 18143 22642 103573 28106 17135 28146 17978 75766 59035 231997 81004 12751 66993 56219 17260 67398 17261 12913 21898 52808 12753 242341 105785 18024 68775 268903 70461 15369 15183 20185 66508 76252 93759 545987 11972 217166 108664 74343 66290 12914 382056 54170 56406 11909 11964 52187 26357 68576 110935 66096 11966 83409 100039636 74370 66335 68441 11973 11974 268706 74915 67605 338375 245670 20656 73834 56484 16476 114143 66237 18477 21672 16906 22627 27060 67838 66144 20459 270669 12282 20683 18044 18045 18046 17969 18128 56438 13856 230099 13058 13057 17970 17972 56453 217365 213539 670717 22230 56445 18453 16175 11657 26554 208677 15526 15926 12575 211586 216799 13555 19645 21781 12571 12567 12566 13557 12447 12322 242705 12323 56371 108058 27401 12325 12448 12034 12576 66592 27377 234663 19386 110651 20112 12418 68097 15364 665113 28113 77683 101185 15260 22166 29817 75560 56702 50709 14957 50708 445007 14958 20657 12151 14630 26408 76408 225849 17248 66401 17165 14780 19763 14778 80838 14775 66403 26462 12428 67305 57294 17246 12460 56455 54383 11833 13619 11911 110147 26399 11927 57321 20293 26400 69590 241915 76650 12416 17436 26398 75221 26420 50527 26414 14950 26397 17134 13875 27407 319152 75512 104248 54616 68350 19821 56551 18104 21749 58193 11758 497652 14859 21750 11757 23939 140742 100043858 224111 12580 109778 69912 216850 233016 12579 71389 12578 106766 16193 667310 23872 14629 103468 23871 50932 26921 494448 15977 235661 26419 12427 234865 170644 12608 30951 59015 69736 21351 110379 13427 11839 14828 12043 18590 13426 13645 12048 13424 21881 17250 18759 110208 11977 15267 66839 64704 319168 58233 15502 319167 18181 14281 13665 74142 67204 76850 26905 15512 319186 15482 319178 319183 319182 16905 236511 319190 50758 56717 319176 69654 319181 213988 217351 226641 56637 214150 13819 14056 101543 112407 17454 112406 29806 319169 319594 26570 108079 54130 20848 625328 78303 606496 319188 15270 56716 624153 23797 382522 233833 232440 13626 319149 13666 11651 11652 15077 269523 52615 19646 11910 13001 13000 100039026 17869 245688 74126 15251 53417 50493 228775 53598 66362 109075 66583 27998 72544 50911 69639 72662 66446 227715 74108 14776 12857 67923 110323 12861 12862 12868 66142 12866 12865 100041785 333182 15510 22059 628438 170762 108989 380975 231042 227699 223921 227720 269113 66679 18141 17684 107939 69482 71805 70640 16475 54563 19069 17992 15361 70699 72787 18226 218210 50490 14229 11370 14228 27207 67097 670832 633683 20044 27050 12343 667279 14080 12345 20085 668144 20084 67186 382492 20055 12340 75617 100043508 27370 65019 629957 20102 20103 668668 667739 672214 64384 66481 71745 225058 100038875 100038991 68028 100043000 67891 100043295 622534 238217 17872 16785 666669 100040021 67025 100043391 668182 241053 12317 432502 19989 76808 19899 100043184 19921 19934 100043755 66105 193740 319195 100043209 68193 621100 19941 665189 666899 12955 100042670 15499 15519 72630 100039316 56354 22121 50497 17168 12017 216805 81489 101142 70356 230676 67669 27103 100037258 219158 270802 100043876 29810 98402 100043893 18415 268933 100043423 110920 56032 100042986 67384 72124 20115 66538 16210 67281 14583 70369 71962 23950 216742 76846 15525 319481 625646 15505 231659 100040298 68196 101148 68172 22791 277854 100042740 80888 252875 19951 73442 70394 69065 667618 100040970 267019 56040 67248 100040331 67941 18412 15481 12858 21762 13198 22123 19179 19181 19182 23996 19184 18033 230784 26440 19166 20463 19167 26441 26442 69077 66997 23997 12234 14381 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 72345 19177 15467 21402 107503 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 17708 20181 17709 17710 19013 13982 19883 11835 18753 14815 20821 110784 18667 19360 56338 17535 22027 12359 84682 27354 81601 14783 11920 16006 12189 228998 15185 100041766 11863 66515 68275 67013 69162 20111 68240 233826 50868 19891 20466 217232 56317 59008 66156 216080 69957 17222 22346 22339 75430 68612 52563 22194 68999 52206 100039535 50907 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 96%3359475 Defective MMAA causes MMA, cblA type 17850 109136 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646303.4 Evasion of Oncogene Induced Senescence Due to p14ARF Defects 12578 DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection 56208 69940 67443 12387 13200 74153 319149 22201 107338 74244 15077 269523 22088 17096 171210 15381 18005 231380 78757 19298 22352 70233 18708 18107 218978 19655 73075 15516 70616 269061 66892 68598 67959 17087 66357 17395 100040603 232989 107701 11806 67480 66286 72047 68092 74326 67500 56298 103573 433702 18452 75956 66861 18550 56031 80744 21898 218490 66270 70225 69019 18451 13684 68879 320632 67418 208643 212880 66585 74351 83486 216705 74370 71586 66877 56529 23983 18521 228607 83701 217069 57905 68479 16834 13690 15569 209416 20222 66899 320452 67838 60321 17713 66070 23845 66810 319322 12282 233726 19205 27967 76936 170786 71702 68981 20639 229279 235623 101943 81898 67439 94315 20646 192159 11993 53317 15382 53379 56258 59013 98758 11991 217365 11834 20168 15388 15387 18571 66055 68816 81910 230861 19766 213539 22230 24127 54633 67465 66624 56445 69192 16646 14827 67285 18453 236732 223697 67958 68183 11771 76479 11772 20624 66642 71770 20847 68137 75062 77134 21349 27366 76687 13205 28000 13204 76938 13207 233908 66125 232910 11773 68219 98985 228410 54451 108062 110611 67337 83410 18789 51786 94230 74320 68188 54188 18458 16785 12317 19899 12322 12323 193740 108058 12330 12325 13163 192292 15519 15529 216965 23888 20971 16211 100039592 16648 100037258 20969 54196 13480 13481 71951 20970 381686 16649 14735 68563 14104 15530 171283 14061 103978 14733 64340 622469 76246 225027 15481 67996 214498 22608 51796 66317 71713 233073 235497 14734 22083 20382 110809 20383 54624 21681 17069 68032 17289 14828 18035 19128 108014 276891 18036 217303 192170 22174 69207 14456 19826 75669 26362 17533 100732 52898 12737 100040029 225326 107686 384091 13682 666609 13681 21872 68705 20641 98053 667035 20638 22190 66420 69833 67710 245841 69920 67332 20022 20020 11603 231329 20021 69241 625018 17749 100043714 69116 22196 621893 15568 319162 15267 319173 319163 319168 22370 319167 319186 317677 319178 12759 319183 319182 17195 319190 12259 12475 56489 56717 319176 319181 20014 72512 103963 13211 69038 214763 227743 13135 51810 22200 319169 109270 67075 66663 78303 319188 319189 80286 56716 68292 19092 16430 382522 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%389661 Glyoxylate metabolism and glycine degradation 100042811 268782 18293 78920 14711 14719 11611 56189 67432 212647 104174 68133 19301 76238 13142 13382 70503 434437 15112 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 96%9834899 Specification of the neural plate border 21415 14472 12387 12159 18505 21420 21419 20674 14175 22416 17701 22771 18509 18999 17863 21418 13395 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447043 Neurofascin interactions 53378 12805 11733 13193 53321 319504 269116 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 96%5579015 Defective CYP26B1 causes RHFCA 232174 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME%R-HSA-9735763.2 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine 18950 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%1632852 Macroautophagy 93739 22241 56208 67443 78610 21821 74244 269523 66105 22334 22333 18541 15499 22335 15519 13001 13000 234663 100039026 12638 11520 68097 26369 57320 108099 218978 52639 56455 666468 77040 18412 73683 213948 66840 228361 51897 64930 57436 235040 12421 66508 68118 545987 54636 242557 15481 66795 66169 67841 54170 66615 28185 100043869 74781 22084 52187 68576 66096 235661 83409 74370 68441 268706 53333 245670 66119 13427 13426 223696 13424 75669 68943 56480 225326 67526 11793 68146 100756 66734 72018 17966 19305 245860 667035 22190 66371 68953 75608 22195 50873 208092 66700 241113 56717 71648 11920 105513 15185 100041766 66905 66410 93765 66589 13819 97287 105787 108079 19079 74302 108097 56486 67414 19082 56716 170731 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 96%8849932 Synaptic adhesion-like molecules 19280 14252 53623 14799 14811 13385 14810 53310 14802 13383 14812 14814 19268 14813 20168 14251 233067 70530 225875 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-9759785.2 Diseases of propionyl-CoA catabolism 17850 109136 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress 12387 12562 19697 19087 19084 16150 11651 16151 14697 54598 14710 63873 14699 66066 14700 14360 18747 11350 14708 14706 14672 18442 14704 16412 14695 22601 73699 14693 64337 14709 16416 19052 16402 14682 78757 21894 14701 51792 19246 54409 18709 18706 22330 18607 74769 11535 18707 14702 18613 14696 18127 19088 56489 56717 104110 109333 227743 432530 55991 210044 104111 14688 640703 224129 109270 11512 11513 11514 71978 12675 11515 12306 20846 16410 12334 18749 14083 12336 18033 69543 17387 16542 14257 18035 56716 19085 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology 18747 640703 20602 12326 21372 23808 20466 81004 66310 433759 140858 56310 15183 20185 213464 381022 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-HSA-450321.4 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 68652 107607 26419 26400 108960 26398 16151 26420 26414 192656 16179 66513 93765 66589 26409 22034 257632 66724 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 96%196757 Metabolism of folate and pterines 108037 108156 100039707 17769 20509 69906 13361 17768 270685 20425 107747 216188 665563 14276 52466 DEATH RECEPTOR SIGNALING%REACTOME%R-HSA-73887.7 Death Receptor Signaling 22241 12633 20663 22324 66105 18049 22325 12015 67384 57257 20662 17164 16800 13605 76580 12070 24105 213498 207212 71704 234094 56349 16801 94275 19418 75547 18053 72754 18412 69632 213649 24001 224014 230098 53972 30938 15183 77669 442801 226970 54126 101497 67733 269608 328967 14163 26382 26419 268739 14674 66552 73341 76686 432940 20598 12675 52440 58994 18201 21844 73218 18033 18035 22627 12125 236915 109934 14103 56480 11848 102098 11491 19697 16150 16151 12367 18759 14694 192656 277360 17874 192662 16179 53376 667035 22190 26409 622434 545156 16443 21937 30941 19164 14102 17207 22029 19165 12366 229603 22258 100042305 268749 208117 106025 59287 21926 74256 100039623 263876 21929 22195 22035 109904 230972 12370 19766 11797 22030 223435 56424 21933 56489 11796 11798 71648 19353 100041766 71609 56321 14082 66513 22034 72843 66724 68652 433759 216080 15182 17136 68585 18377 235402 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX 14069 14058 14071 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450385.3 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 72544 50911 24127 69639 72662 66446 227715 70640 75901 54401 11651 12192 17164 66362 109075 66583 27998 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 96%9616333 Defective Base Excision Repair Associated with NTHL1 18207 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%8948747 Regulation of PTEN localization 19211 667035 252870 18854 22190 17999 11798 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex 68092 433702 20922 68705 98053 13871 66420 69833 67655 67710 245841 69920 57314 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 58202 17420 12572 13872 27632 20924 24116 23894 14884 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) 70061 79235 98711 19682 102294 20897 19662 216454 15485 17252 27400 77974 241452 19661 19659 212541 19892 22139 17921 235033 11304 19771 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 96%9761174 Formation of intermediate mesoderm 17300 14234 12159 18510 16869 18504 14173 23967 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 96%380270 Recruitment of mitotic centrosome proteins and complexes 20873 68121 12534 78887 22628 225745 231123 227613 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 259279 83922 171567 51885 75296 26370 76789 72083 12537 76707 233276 103768 74237 219072 13589 225659 18472 76478 78177 28135 214444 76816 54130 18817 381644 13427 22627 13424 27373 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%R-HSA-3642279.3 TGFBR2 MSI Frameshift Mutants in Cancer 21803 21813 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 96%111458 Formation of apoptosome 56369 670717 11783 74268 72565 66593 12371 26413 11798 26417 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway 16451 12534 208884 18039 18183 14810 83961 11472 100042150 20779 23859 14814 17295 109880 216148 26413 26417 14360 29857 12988 20416 327826 109905 20418 13649 19730 21802 54401 26395 194231 26396 54519 29875 18176 245684 20662 22371 16416 15461 75590 110157 231474 23980 18218 14161 63953 21894 13537 215449 19252 11836 240672 109689 216869 26403 72399 18708 18673 18709 16452 110135 99571 18706 22330 16706 74769 14587 14586 19197 14588 19262 545987 640703 19419 83409 240168 15234 18188 18596 11876 56438 18582 56327 16184 16183 19713 19060 13385 18595 70686 53310 13383 16453 54721 19046 13866 110606 26554 226525 14272 18015 320484 211255 240057 101809 54153 114715 114716 19414 69601 19415 14083 218397 114713 16188 16185 12984 12982 16192 16191 20739 20740 640524 20742 20741 20743 12322 12323 108058 12325 16186 14255 17967 80297 320139 56705 19047 73699 19052 19053 51792 226849 225849 26931 14573 21770 26932 12223 19417 19418 71920 13874 15200 211323 14585 16193 18777 21762 22123 14812 19179 19181 19182 70178 23996 226016 19184 107971 19671 436004 26440 216169 16653 19166 11839 19167 13645 12981 26441 12048 80903 384783 26442 69077 14186 66997 14165 23997 56436 16367 17463 14172 57296 80857 20422 26445 14170 26446 19172 14180 19173 14178 19175 14177 67112 19177 64654 14175 14174 26443 14173 26444 14164 83379 19170 66413 667035 22190 59029 16194 67089 70247 57295 16399 14268 235584 67603 319520 19731 18611 18591 70727 21687 11600 19732 17532 76089 171463 56392 67836 71746 14256 19247 18761 233046 17169 57437 16590 19092 KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway 67443 12575 13666 11651 11652 269523 27401 13001 13000 100039026 17869 50493 22166 20657 14630 76408 328572 15368 12013 11911 20293 76650 17436 17135 75221 17134 18412 27407 68350 18104 18024 14859 140742 224111 71389 12578 12914 14629 26357 21762 22123 19179 19181 19182 23996 21351 19184 18033 230784 26440 18477 19166 11839 12043 19167 18590 13645 26441 12048 26442 69077 66997 23997 14381 12234 56436 17463 57296 20422 26445 26446 20683 19172 19173 21881 19175 17250 72345 19697 19177 18128 21402 56438 26443 26444 19170 18759 66413 26965 667035 22190 59029 67089 70247 110208 18753 20821 217365 22230 50758 12189 56637 26554 50868 233826 26570 108079 15926 23797 REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 96%888593 Reuptake of GABA 232333 14412 14411 243616 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 96%5579020 Defective SLC35D1 causes SCHBCKD 242585 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle 207425 56320 214230 56374 106326 12389 210998 22319 241656 269523 192662 20514 386649 11857 13171 14570 72565 19349 70584 66508 12988 229658 19877 238505 74734 16818 14467 19878 13830 224105 16480 218756 22637 22042 18479 22143 56784 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 96%9839406 TGFBR3 regulates activin signaling 21814 11480 16323 16322 PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-HSA-212300.4 PRC2 methylates histones and DNA 319178 319183 319182 232440 13626 319190 319149 319176 319181 15077 17765 14055 21652 74016 16468 52615 103551 19646 14056 13436 13435 245688 13433 319169 11569 625328 15267 78303 319188 319168 15270 319167 624153 319186 382522 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 27410 RAB GERANYLGERANYLATION%REACTOME DATABASE ID RELEASE 96%8873719 RAB geranylgeranylation 270160 56382 19326 69834 19328 12663 19332 12662 328778 11891 67295 19329 19349 59021 224624 242681 53869 69908 76338 19340 226422 19339 19376 53868 56187 19352 76877 58222 19244 17274 75985 80718 19324 19325 68328 68365 72433 19335 106572 19342 19336 67790 19341 216344 67844 270192 77407 19345 19337 271457 19344 19334 319642 19346 235442 19331 19330 76308 19338 217371 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells 12400 16854 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 96%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 50933 22201 22209 22225 53323 22284 109161 22193 22213 667035 100041766 67128 22190 216150 22214 67615 268470 252870 432940 66799 231380 216080 67196 22195 68612 22210 22194 100039535 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 96%5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 232910 11773 14367 57265 22418 11771 11772 71770 26563 67300 26564 12757 74325 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 96%9845619 Enhanced cleavage of VWF variant by ADAMTS13 279028 22371 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-611105.8 Respiratory electron transport 67876 68267 66690 76826 69702 66278 208501 54405 17991 66091 69487 108755 66272 239760 68015 66414 67388 66379 68472 104130 75597 66928 15159 68493 76947 67044 67273 68198 66495 67130 66416 68375 66108 52892 66836 68342 76178 66377 68197 227197 67184 100042503 66046 230075 66916 66218 69089 226139 14719 14718 70316 17721 17722 17716 17717 17718 17719 67105 12858 12857 68033 12856 110323 12861 20463 12862 12868 66142 12866 67264 12865 100041785 22273 66694 100042918 66576 14297 67530 544717 56046 100040287 333182 380840 17711 22272 66152 624814 75530 67267 66821 56384 26940 100900 17708 72795 17709 107197 17710 66445 110826 67003 68202 380975 84682 670717 17992 229211 225887 72900 226646 17995 595136 623286 66706 235169 78330 67899 210582 66359 52469 66349 76916 69802 75406 15526 66945 73694 66343 66841 94281 66052 67680 66925 110842 71803 67863 70207 78830 231430 50799 20930 17449 66271 17448 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 56436 17463 16449 57296 20422 26445 11487 26446 54485 19172 19173 18129 19175 19177 18128 18132 21402 56438 26443 11651 26444 270118 19170 66413 26965 667035 22190 59029 67089 70247 15213 15214 17127 19164 19165 15208 100042305 208117 59287 100039623 103806 328572 333639 21335 12914 14534 18519 22631 21762 22123 15205 19179 19181 19182 23996 19664 19184 26440 19166 14257 19167 26441 26442 69077 66997 23997 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 96%9638482 Metal ion assimilation from the host 15129 15122 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%211945 Phase I - Functionalization of compounds 17161 109731 13075 244209 69574 68021 11670 13849 20186 237940 13123 104086 11754 13122 67758 109857 18105 212503 67247 66112 15516 13087 13116 13107 436059 14261 13115 13106 110115 622127 56050 11624 18984 11622 72303 107141 17977 13088 13077 56448 13076 13114 74134 17978 72082 13110 13113 545817 13070 19224 66427 320997 76507 13120 631304 13118 72054 208285 64385 21391 19223 13124 13121 55990 14262 20181 104158 11668 102294 68165 14149 14148 13082 13081 13072 60525 72535 232174 13079 11529 68738 546726 11522 26876 71519 11532 106648 11669 13909 100040843 13078 11863 11864 11632 100043508 18976 109754 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 19763 17187 13626 19361 211586 67057 13619 13555 110147 21781 241915 12189 56353 19821 225182 52615 29808 22294 20135 19646 12419 50496 12545 14056 245688 71041 12417 12649 11783 77683 13831 214669 12151 22658 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis 14149 14148 14297 380840 74316 73046 246696 67712 100900 68165 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 96%1482801 Acyl chain remodelling of PS 18778 14792 18783 329502 218121 271844 18779 26971 74486 99010 225845 26970 26565 18784 79196 18782 237542 78390 66350 85031 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-HSA-1660661.12 Sphingolipid de novo biosynthesis 67260 227102 268656 228677 93898 242083 17250 70750 76303 30960 71949 75292 66612 101540 67630 103236 26357 76893 66427 432628 74442 66183 338521 20773 545975 241447 104725 66844 56632 20698 56491 18760 70059 13244 208449 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development 18747 81004 640703 20602 433759 12326 21372 56310 15183 20185 20466 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins 17342 56208 107508 22094 12640 15925 51798 171210 15381 109331 12848 216233 12700 100043806 26891 66286 18550 21812 21813 75705 69019 13685 13684 28185 208643 68441 56529 22318 20907 11789 20505 20531 66397 69608 218811 99683 192156 56453 77371 20334 20390 217365 15387 22195 50873 17002 19766 11797 22230 22030 66624 108155 11796 14827 68137 76687 227112 11957 11947 11949 17705 11946 15526 432676 99375 22210 72584 11847 58186 13194 67561 67711 76843 66341 26885 109113 223701 100040573 67241 66647 67872 65973 67040 320213 20230 56459 50995 55989 68501 226026 17190 75826 223870 224903 21973 21974 21969 18747 12418 22166 29817 12151 17248 19763 12428 17246 54383 13619 241915 12416 75221 68350 19821 224111 12578 16193 12427 30951 11839 13629 67160 66656 55949 13628 11487 12266 625018 76768 13665 67204 108067 217715 26905 13667 209354 224045 26374 20617 103534 57377 100042651 70546 108687 269181 19341 217664 77407 107895 19337 20446 20444 74105 20442 20443 260302 17308 235442 17158 20440 67569 14376 19338 20447 53618 20448 227619 19089 19326 106039 12419 16002 16000 21849 21802 74126 67731 218214 21825 214669 71147 56454 53895 270166 320183 27361 76467 110265 18537 12702 14462 14463 15258 14308 14534 12857 216848 12662 18148 53376 19211 230899 11540 18619 66494 15510 22658 17283 69076 16866 57743 53421 100043039 66212 12343 12345 18519 12340 21857 16323 16322 268977 22632 20750 14479 18854 56207 84092 110616 11816 66105 22130 17125 17126 17127 17128 66313 17131 16600 22284 56456 12858 107986 69260 16334 223499 17708 17709 17710 235505 56187 54601 12321 19352 20255 16009 16006 80718 104009 70945 11625 252870 212712 18815 20878 20466 75396 11804 15182 71393 110962 15161 75302 68837 22223 50933 20602 17425 71599 228790 12005 240087 56233 224139 21420 21419 14161 207958 71853 20818 109689 107513 216869 99571 22393 13191 192193 67398 105785 18002 12870 22041 71902 13171 13382 66124 30941 229603 22258 74256 21929 12836 68453 100102 18453 66113 11657 11807 11808 12984 12982 272411 231050 78754 333424 210004 108760 71685 26887 14426 108148 171212 232984 108105 241391 14595 207839 233733 15275 108150 212996 97440 654821 72077 50935 271786 14537 67909 108902 69597 66865 68514 22334 22333 27377 22335 15529 69029 234847 14422 54613 12159 15530 56336 56386 235504 19325 68328 68365 231727 14734 57370 53418 56375 268510 20845 227327 53625 21923 14118 16846 56737 320438 208624 102580 24070 208211 381903 13478 328370 22031 56489 14465 72535 11669 15108 116870 106021 17390 14423 381677 24108 102323 54638 100737 73828 66199 56468 230796 415115 80913 27784 114893 54607 99311 71991 28199 74106 78309 76863 240263 66498 52245 98193 64658 434130 66419 17846 64660 320808 78523 79043 94061 66200 623346 14155 102060 53417 50529 76501 233870 242418 100040519 69456 68565 59043 99045 14154 66973 12238 69163 68842 52443 66398 69089 75763 66077 233805 68611 234664 94062 74251 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 67681 66399 64655 107733 68537 18100 67707 94066 60441 218506 66230 68463 65111 74600 107734 107029 66242 28028 68735 622268 27398 94067 28030 67840 68836 79044 68263 94065 228026 57312 75398 68572 67308 64659 56282 66292 24030 66121 66163 68499 18597 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 235339 66223 11848 17228 11905 21810 68396 12307 56224 69592 13010 20219 67847 16432 20660 23821 232670 51788 19349 17304 22139 624814 52588 70423 56418 70361 104158 13809 16572 66251 16573 12922 69048 57394 14943 16574 234155 18548 27226 17380 12876 16790 76703 16326 12873 16709 70495 11421 100038824 16325 16324 239436 12591 18549 236781 13482 67475 56389 108037 21780 110119 11842 69080 331026 29858 54128 27410 14853 16392 170822 71745 225363 18458 13138 14852 14314 67311 225742 236082 107652 26938 20451 19703 245847 227697 20445 20449 54342 19025 50798 66174 57357 50877 56174 14583 13480 14584 234730 13481 22122 241230 75540 228368 66248 24060 240119 218138 20454 109785 52014 12764 20450 57170 69064 94181 74091 68563 67422 20452 18010 241159 23956 216197 70008 83995 18412 77125 11840 15481 64138 67768 108645 67674 11551 11553 64654 117589 78541 69299 233902 50760 235320 242521 209239 74492 66799 72194 15204 77038 69706 217194 226541 65257 78913 242785 56791 211949 233040 231672 231863 101358 12449 224023 109161 22193 71538 67455 14794 217217 71999 269529 17155 83962 17156 230654 230815 635668 66515 13177 269514 78889 68431 230904 71865 380928 50868 207215 72433 22200 627648 75717 106572 67921 22192 67790 142688 243574 216344 67844 74646 448987 22346 228003 19330 212919 20439 20437 270160 19823 22201 19328 22209 12663 53323 70620 330369 66853 140499 50788 22213 67128 22214 101206 67615 268470 230903 66772 208372 76454 65247 65255 84585 142687 78910 231380 65256 70392 225055 11655 232539 14151 231670 56444 67665 69754 22428 77113 12344 207952 59288 320118 30843 68854 76294 72323 399566 68098 214931 13016 13436 13435 13433 100042305 208117 59287 100039623 18970 17918 73582 13035 11541 242851 216799 72607 68031 73162 19720 21951 74493 14799 18195 18508 192656 20210 24110 257632 107607 231130 59025 69654 17274 53413 11843 20336 107371 54130 16008 105504 16005 66940 211446 208659 13602 16007 16012 102058 16011 16010 246228 13801 12653 11698 20254 56047 19672 94111 13406 30060 15464 69940 11704 71421 217847 18491 107338 77583 105348 80752 23850 16852 18220 15160 66482 626834 20856 66848 338366 83554 11576 66557 98170 17182 16425 232146 12155 76453 74761 53869 100683 53598 104318 101565 13036 26370 217869 226982 66967 223455 66597 108123 320011 108124 23802 22644 66435 76332 75841 16834 270192 319642 102339 19346 338337 17957 67542 56382 69834 97484 233824 17711 22272 67003 20226 13033 99138 13207 20739 20740 11733 11735 640524 20742 20741 20743 80297 12038 11423 19339 22224 56505 225280 242362 26893 56249 69714 227195 109275 26894 68142 108679 233875 70020 19358 19359 235134 22591 26572 21762 432940 22123 26895 67041 19179 19181 19182 23996 110446 19184 15360 19671 436004 26440 71911 19166 18035 19167 71941 70120 26441 381314 67417 26442 226153 102436 69077 74776 66997 109093 23997 212679 12234 70560 56436 71984 17463 224805 57296 353172 20422 70791 26445 68915 26446 230577 19172 226539 19173 381760 71807 19175 69955 19697 13682 244141 19177 13681 21402 27979 56347 26443 13669 26444 53356 16151 68135 19170 55944 66085 12042 73830 66413 16341 26965 223691 667035 22384 22190 54709 100042807 98221 59029 66235 26409 67089 68251 103583 20184 70247 269582 22260 20181 70681 22337 70238 19013 27223 56469 19365 13982 22025 107976 19883 210766 11835 18227 14815 59004 20610 208727 19016 22196 71974 100043429 621893 110784 26423 319162 19401 319173 229615 319163 21834 18667 22027 12021 22427 19090 12189 20388 67091 18538 20703 66226 74143 19324 12144 105522 243819 68275 14067 67013 69162 14275 12793 67857 100042773 233826 20333 215474 207352 74498 66682 52036 76983 13032 245828 12794 240667 67727 214895 59005 14069 78232 216080 56041 333883 21787 27096 67269 68612 72978 330010 227648 66648 22194 76308 69216 76510 231093 100042343 70892 100039535 50907 102747 193813 74410 12068 237930 317717 238328 12534 56494 67534 60409 74711 12387 89867 244071 235416 101100 216131 320244 67231 625850 66890 223723 56324 271813 110012 15239 66257 69737 226841 20844 76223 319953 59021 328572 11806 17977 238055 19017 17978 52815 18024 56322 268903 433806 15183 12914 100043869 640703 30059 11429 30056 11820 99412 12974 12530 636544 11555 66885 66948 56438 14607 100756 22226 14697 67295 19329 170711 14710 330908 14699 80883 66066 212518 14700 54644 72434 97884 14276 70527 14708 380959 14706 110826 224624 74270 14704 76630 71472 14695 69908 56447 104416 54161 83563 14693 76338 225896 66889 64337 21684 14709 74112 15874 108138 246190 216825 414084 433931 226422 14701 329777 320772 67196 109979 27392 109978 269295 14731 11889 11890 59007 54198 70325 59042 14702 12182 14232 246103 14696 69641 68468 14526 76877 58222 276846 239706 244682 56395 18700 67292 320204 11647 110417 71897 11650 18701 80294 18488 67556 17068 21683 71003 79464 68043 66913 67133 14688 56748 14756 59040 26554 71954 239827 327942 55981 98388 211255 237847 21838 235106 19335 50797 19342 19336 70349 12847 70163 67843 67164 241062 68133 13003 215494 228366 19334 235323 320840 246179 70574 19331 114654 16588 74996 12091 217371 11881 319651 76942 54160 224836 105450 228812 12575 64931 360216 107260 66111 170745 74762 54399 18793 217615 19332 328778 68311 22217 12447 68149 230801 68404 27401 227753 207965 13163 20389 74653 12448 170707 235441 26434 68947 57783 73068 268890 226418 216395 75847 72585 234663 23934 242681 109359 217057 19386 109154 53614 213827 11799 327799 52276 11844 53334 22242 19340 20842 72096 68097 69363 16319 72084 70511 217364 67511 668145 20877 56358 72373 24061 76486 76800 234700 70675 56703 445007 19376 19357 53868 57256 232973 30940 56746 243853 140703 623661 57294 78928 56455 66459 171167 71665 67099 22225 19244 320713 70316 75985 107995 108853 211253 320806 17721 17722 17716 17717 17718 17719 105083 17720 24015 67871 68366 20585 69912 76246 108089 13006 214498 225131 56273 103468 66317 668173 103737 72129 19302 235661 235497 66510 234865 22083 268281 109815 233900 320311 59015 54624 69736 17069 110379 13427 19128 13426 13424 14456 20843 19109 75452 77987 20387 12945 224792 52713 16541 17309 30937 245049 11891 66904 14148 15267 319168 64704 319167 74142 382014 319186 319178 319183 319182 193670 54197 319190 26754 319176 18034 216440 319181 20014 103963 69038 13135 13819 68646 67819 20687 116891 15248 26927 20338 235606 319169 67075 20848 625328 78303 319188 15270 80286 624153 68292 16430 382522 67895 13200 319149 72297 15077 269523 140858 12558 52615 213464 13001 13000 100039026 17869 245688 15251 12638 57320 12006 66357 21416 216185 15107 67923 19123 71586 230073 71956 228607 217069 12466 22147 19345 21454 271457 12462 19344 22151 106052 70430 66887 242960 12467 30838 12468 22143 12469 21371 12461 14466 12464 30050 108903 50762 72726 14675 53857 24012 24128 19739 22327 22152 227613 50782 22153 50754 216853 56327 50779 22142 11461 22146 14976 67199 18637 108077 67466 67951 27055 71833 14672 14447 213980 66411 73710 68628 14676 22145 22059 12465 16553 55946 50789 545486 238463 30839 14682 67134 109054 56612 20698 99371 170762 108989 231042 227699 223921 227720 269113 66679 18141 107939 69482 71805 433923 11740 54563 19069 70699 72787 18226 218210 108153 23794 30806 108154 16795 27207 210417 67097 271127 670832 229595 208936 17995 633683 77739 20044 381694 27050 269959 667279 14425 20085 269328 78330 668144 230145 20084 100689 67186 233744 382492 235130 20055 240322 75617 20357 27370 65019 11504 629957 20356 20102 17829 67834 21803 18636 269951 20103 100039649 668668 21826 667739 140474 224116 226866 672214 217734 17063 66481 59048 225058 240913 100038875 223838 100038991 99011 68028 237360 100043000 330119 67891 216725 100043295 73732 622534 66548 238217 330267 207596 16785 224697 666669 56229 100040021 353328 67025 239337 100043391 68273 17991 668182 77794 241053 94192 14194 12317 279028 432502 19989 76808 19899 100043184 19921 19934 20917 100043755 11545 12330 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 18442 19106 100037258 100043876 100043893 100043423 100042986 20115 67281 76846 227197 625646 67184 100040298 68172 100042740 230075 19951 667618 100040970 66256 267019 225642 20832 56040 67437 67248 66661 100040331 217337 67941 24067 66789 27058 66384 20813 11606 72265 14061 26464 22361 107221 385643 233081 18293 78920 72345 14068 71952 66632 13495 102115 58911 63828 107817 22021 276770 271970 56316 14058 69082 14071 67902 66901 22022 69740 13494 194952 545260 269955 57295 238024 11883 77035 67014 67228 66521 105638 99349 74008 16777 77041 16779 270086 208691 226519 330817 14268 67728 116905 15007 12010 14661 213753 66855 66244 69666 76788 16912 52231 19171 107047 66537 56373 19185 19192 73902 66998 56088 67151 53380 66506 16913 228769 103554 19186 228998 19188 100041766 216150 66513 93765 22034 107045 226414 97541 239555 216443 22375 234734 107271 69606 27267 105148 23874 76784 231872 70223 76366 66143 67851 15115 18976 110960 66590 433759 22321 12977 319189 104458 85305 13722 17448 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 96%112308 Presynaptic depolarization and calcium channel opening 12286 12287 12290 12300 12294 56808 54377 12293 12295 12296 12297 12298 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives 14775 625249 11688 14776 11687 19225 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants 16706 20779 12322 109880 12323 108058 12325 26413 26417 12988 109905 640703 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 16653 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9955693 NAGS variants cause NAGS deficiency 217214 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 96%5210891 Uptake and function of anthrax toxins 18550 640703 18571 26395 26396 26400 26398 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 22589 13163 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 96%3108232 SUMO E3 ligases SUMOylate target proteins 66341 26885 17342 109113 223701 100040573 67241 20602 66647 18854 67872 67040 20230 55989 68501 19720 226026 17190 224903 21973 11545 21974 21969 13163 52615 12419 240087 56233 21849 19106 19386 21420 11799 21419 52276 15381 20842 12418 16319 57320 20877 24061 214669 445007 19357 12151 328572 19763 17246 54383 13619 17977 19017 241915 12416 17978 26370 19821 268903 15258 69912 12578 13006 12914 103468 22591 234865 30951 59015 69736 110379 13016 18035 20843 69260 216848 19697 16151 18148 22260 20181 22337 70238 19013 13436 27223 56469 13435 19365 13982 13433 22025 19883 11835 18227 14815 22059 59004 20610 208727 19016 22196 108138 100043429 110784 26423 19401 15204 229615 21834 15387 18667 170762 108989 231042 227699 223921 227720 269113 66679 22658 18141 107939 69482 71805 54563 56489 22427 19069 70699 18034 72787 18226 218210 12189 18538 12144 116870 68275 13207 106021 20687 15248 26927 212712 20878 20466 433759 22346 15182 67711 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%75108 Activation of BID and translocation to mitochondria 12122 18107 12370 14939 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 96%977347 Serine metabolism 107272 56442 26943 236539 257635 231691 27364 218442 230779 574418 100678 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%163765 ChREBP activates metabolic gene expression 14104 55979 104112 107476 100705 58805 21428 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%8854691 Interleukin-20 family signaling 213208 237313 242700 16451 338374 93672 58181 116849 20849 20846 16453 20851 20848 20850 54721 16155 20847 230828 19247 16452 329244 237310 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes 328572 12914 14629 15368 12013 11911 26570 76650 17135 50493 18477 22166 18104 18024 14859 20657 71389 14630 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum 18129 18131 224143 140484 18128 18132 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%212165 Epigenetic regulation of gene expression 15161 232440 20602 13626 319149 23989 67155 20586 20588 217031 20587 226976 208146 11450 66853 18631 15077 76719 17191 57435 66310 68801 75812 140858 21835 14311 69556 69612 68975 52615 101206 14081 19646 13486 234366 234959 101867 213464 217588 12419 54194 108946 67933 214162 665775 75565 330890 228714 28077 70208 67773 239510 21849 245688 21664 77305 171285 23808 11520 23942 56771 19014 328572 21372 231051 239985 17977 74322 19017 21374 17978 81004 66993 56310 208043 26896 15183 20185 93759 12914 20018 56406 194388 18140 14534 20016 22289 27273 237758 12568 216848 107932 14732 20249 243834 81898 11461 110052 13436 13435 13433 55982 93762 68094 22385 83796 83797 57376 244713 229542 434178 67279 108155 16475 57875 17283 67278 23945 16890 101739 16956 50724 52463 60406 17765 14055 14245 21652 74016 103968 16468 214133 103551 17979 94246 67800 100041953 71954 11770 26424 18519 19645 667501 57230 21429 59024 20019 327987 269003 21340 21339 432769 21341 64424 22130 75316 70333 233904 116848 66136 20017 11350 12491 75410 54343 11569 17192 77683 20937 431706 84505 319955 110147 56456 56200 69790 93760 170826 381022 70127 29861 269397 19708 75339 232854 67010 268996 70650 13871 12055 66420 12054 69833 77045 245841 21408 223828 14885 209357 66467 12606 20181 72198 66671 17749 100043714 17420 12572 13872 23894 14884 22196 100043429 15267 319168 233060 319167 264064 319186 319178 319183 319182 228829 319190 18432 319176 74522 319181 56637 116871 216154 116870 20467 14056 51813 319169 69792 67512 12417 20466 625328 78303 54427 67381 319188 100039610 15270 433759 622480 624153 15182 382522 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R 14389 74769 16367 14172 80857 18576 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 327826 16370 16002 16000 18176 14388 20662 15461 16001 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 18607 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 96%166520 Signaling by NTRKs 21990 56437 14066 17095 12570 20393 15902 15901 23938 17172 54152 20408 15903 14283 211770 20779 16478 17936 17937 20404 11838 13656 13655 381677 107746 103967 109880 12929 26416 12928 56044 64143 18049 216148 26413 26417 29857 20416 327826 18211 109905 77480 19094 20418 102626 19730 54401 73699 26415 26395 26396 19762 110651 18176 20112 20662 19769 15461 17164 19052 19053 51792 18708 18709 18706 328572 74769 19280 21770 13712 18552 15904 18550 18553 16477 17260 17261 23939 11909 58202 13430 12064 14812 14388 21844 18212 208869 18205 107971 78405 18803 12569 12568 384783 16367 18213 11848 73086 107932 17258 11540 21406 19712 11516 19277 11517 100040260 101568 235584 67603 319520 72349 14281 13654 20807 14282 13653 19353 11771 11772 12028 71770 19247 20111 232910 11773 20848 67300 13429 12757 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 18132 21402 56438 11651 21335 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 22631 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 96%444257 RSK activation 20111 67071 26413 110651 26417 20112 18607 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%451927 Interleukin-2 family signaling 14389 74769 18707 16451 20663 16453 20851 16198 20850 16199 20963 14784 18710 19229 16186 16331 16332 16184 20416 16183 60505 15170 60504 20849 16169 16168 20846 20662 20848 16188 16185 12984 12982 16192 16191 16818 12981 18708 18709 16452 18706 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival 13479 58861 246256 14131 11491 19087 19084 22612 217344 20620 14697 93671 16153 17886 26416 14710 14699 66066 14700 229709 14360 16438 16439 18747 14708 14706 14704 14695 16440 12502 14693 17096 64337 14709 14701 15162 14702 14696 19088 234779 19108 104110 20963 14678 18550 14677 14687 14679 432530 210044 104111 14688 16193 640703 70086 224129 11512 11513 11514 11515 14191 18749 14598 18803 319446 11541 23887 14129 242851 19085 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 96%9609736 Assembly and cell surface presentation of NMDA receptors 14811 13385 18039 14810 16559 53310 11472 13383 23859 14812 14814 108030 14813 12322 12323 22343 108058 12361 12325 319924 170483 22342 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 96%5654696 Downstream signaling of activated FGFR2 327826 14172 80857 14180 14178 14177 67112 64654 14175 18176 14174 14388 20662 14173 14164 15461 107971 18803 80903 18708 19247 14165 18706 MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 96%9683610 Maturation of nucleoprotein 214424 328417 606496 67287 80285 52552 56637 671535 547253 22196 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) 64176 64051 20614 75209 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 242425 14702 14696 16519 16520 54393 14697 16518 16516 14710 14699 66066 14700 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 14693 16517 64337 14709 14701 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 96%975577 N-Glycan antennae elongation 20451 14595 103534 56336 56386 57370 269181 53418 241230 56375 107895 20443 20440 67569 20450 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 96%1266738 Developmental Biology 21943 20437 17342 20665 20682 18992 15901 209446 17202 107508 17201 21425 22325 57257 19877 11465 19878 67224 15516 66999 12609 17395 17216 17218 65254 319713 14587 14586 20358 18550 19122 18553 19197 12517 69585 210801 14588 215798 114873 75705 20346 19262 16678 19264 216439 13684 20351 12292 15357 244058 208643 110789 17528 22288 108098 26757 19153 83433 18845 22253 17196 20349 140571 18858 22177 18846 231148 56216 22240 57764 623279 66172 13497 13508 76829 54712 20361 20907 192191 114255 18188 12933 110351 78334 214968 11876 13449 13448 68799 226251 216963 20933 13121 20788 381379 67219 13385 53310 13383 20526 19164 19165 100042305 208117 59287 100039623 76199 17918 76709 53378 73178 56443 22359 19699 13131 68089 67771 11867 56378 66713 74117 57765 17909 20230 16881 18747 12491 110651 20112 12418 15260 14013 12151 19763 54383 13619 26399 241915 12416 19821 23939 216850 12578 70834 23871 12555 12386 21413 494448 54377 17877 17878 12175 18209 12561 12608 17927 30951 17928 18007 14812 14388 21844 12300 54376 18803 11839 81905 12043 13645 67071 13388 246086 16449 19213 18508 21410 11487 21405 11925 18088 18096 15376 18012 18609 15379 378435 15377 320995 22431 53626 17258 227377 117172 56735 77055 75706 26560 435286 320864 94179 406221 69533 629873 69473 109052 70810 223917 100039486 68673 670464 435285 66708 100041488 223915 406220 16681 16675 16663 16661 268482 16682 110308 16687 110310 16691 107656 100040248 16664 239932 16665 16666 16660 16670 16694 77914 66809 71369 435273 16667 16668 105866 16680 53622 16679 406222 71888 16671 16672 53617 114566 406219 100040249 546511 76444 268905 332131 170654 74127 237934 100039757 14810 626834 17886 70625 68975 234959 21418 94112 15213 67268 70208 100043167 230594 547035 214290 13649 21802 218693 94093 15111 23942 56771 80509 104625 13395 18983 239985 57246 17292 14462 21380 15110 14461 214384 12180 14463 26896 218772 19411 103988 14534 53621 19664 72068 232791 17863 18987 216848 232232 12865 18129 107932 170787 75605 110052 19713 68094 83796 83797 57376 243743 229542 22658 67279 17283 20851 20850 70315 21349 18986 17979 13866 15375 12289 22278 18519 18222 16571 21367 53870 24046 13844 16728 12661 16825 18187 11480 13429 13193 19684 12934 16536 30942 17698 15378 110862 104099 20739 18534 20740 235281 22632 56613 74947 20266 20265 12805 20375 11733 11735 14432 640524 20742 241226 20741 319504 79221 20743 26394 20271 59024 399548 327987 20272 20274 20273 103967 11658 110876 53321 20269 72821 110880 22350 17967 269116 71653 80297 20264 213119 11350 56705 17125 17126 17127 17128 17192 17132 228140 103806 16600 69125 12295 12296 12297 12298 333639 50796 56456 19215 22762 69790 58184 93760 21762 22123 19179 19181 19182 23996 19184 18033 26440 19166 170826 50794 13190 19167 26441 22173 22178 26442 69077 66997 381022 23997 56436 17463 78893 57296 20422 26445 16334 26446 19172 19173 19175 56458 19697 13682 19177 13681 52846 26443 21388 26444 18091 19170 21423 231464 66413 667035 22190 64058 59029 67089 75613 70247 21406 20181 14106 19013 66556 208727 19016 22196 16399 26423 16402 19401 21926 264064 15978 20807 81601 54601 14783 12399 12189 20852 15185 320202 15184 216154 12631 51813 69792 56057 15205 12193 382035 20466 67381 18817 15182 12387 20602 58194 12550 23989 67155 20586 20779 20588 20587 20404 17295 18844 270118 14786 11819 223881 26416 227937 234366 26413 18787 26417 29857 20416 327826 28077 56233 19094 234594 20418 15214 54401 171285 21420 26395 21419 26396 18176 20662 20765 70166 15461 16416 13706 66203 317653 71529 21894 69511 21816 20129 668304 66344 13507 19014 16480 13506 229003 13505 386463 213498 99681 14027 12365 328572 110596 76770 19143 72432 67451 259277 16769 21372 74176 109151 19041 68668 76560 17977 11852 16939 20754 19017 13367 240633 56460 103573 17978 59035 81004 66993 17260 69632 17261 53972 15183 20185 93759 11972 108664 66290 235611 12914 54126 56406 11964 19056 11966 100039636 18018 66335 18019 11973 11974 11853 12336 56484 16476 114143 22627 12569 12568 12531 12333 18128 56438 77579 71960 20354 20130 16885 16886 22412 22410 22411 12830 18241 12829 12828 55982 12827 12826 20423 15874 12841 22417 12840 245026 12839 14048 13363 12835 12834 12833 12385 20613 57875 15227 18514 67784 16956 22416 11771 11772 71770 22408 16147 18738 232910 11773 20849 16162 218397 18749 16191 13004 12575 211586 13555 21781 12567 12443 12566 12445 14182 15529 16189 16163 58198 23967 16371 17300 14573 20472 279653 14234 57294 12159 15431 15412 16869 18504 18993 15396 67701 114249 13797 109663 15403 15904 14585 23892 231507 18510 76707 16372 20471 14733 208718 20528 620395 11481 23863 12622 18119 13590 269275 11479 18999 99377 22773 100038891 76499 13835 19109 245049 13511 70127 13510 16364 29861 269397 18772 20431 109620 19708 13512 268996 11891 171531 12055 66420 12054 69833 77836 67710 77045 245841 83671 69920 20022 20020 11603 231329 20021 69241 17749 100043714 21679 15267 21676 319168 68910 319167 13591 14281 16846 224105 18139 13654 67544 76850 230753 239528 319186 21677 319178 319183 19876 319182 259302 223666 20563 236511 14270 319190 117600 13813 20671 20997 14836 383491 27217 332221 14465 83557 319176 319181 19353 213988 217351 56637 214150 70673 22227 12683 12686 19247 94187 13819 116871 12162 51810 116870 13592 13848 13846 13845 14056 270190 13842 13840 17454 17390 13841 319169 13839 57810 13838 13837 66355 13637 13636 13643 13642 13641 20848 13640 13639 625328 13638 78303 319188 15270 18750 624153 68292 17136 23797 382522 233833 11488 21415 56839 232440 243914 246316 13626 23792 319149 213469 11496 22628 16842 17936 22612 17937 11651 11652 11450 15077 12047 21385 66310 69675 18710 19303 140858 12558 97064 13612 11886 21417 52615 232313 21752 19646 329581 213464 14360 214162 13001 13000 100039026 17869 245688 22601 17096 23808 53417 18708 18709 18479 18706 12288 74769 18707 21414 21416 231051 18481 68092 107449 107448 22772 433702 75467 194388 18140 214899 74319 11628 22289 67923 20815 11848 14159 73086 11461 70584 16412 545156 16443 22059 330662 58226 12291 13836 239556 67938 17904 17268 223435 15400 17344 232906 16475 16658 15407 67278 17880 15401 13018 15423 329559 15410 103889 18771 15436 15434 15394 15429 103968 27207 67097 670832 633683 20044 27050 667279 20085 668144 11770 20084 67186 382492 20055 75617 27370 16848 65019 629957 16410 20356 20102 14083 21803 20103 268721 668668 11352 667739 14853 17974 67300 16392 672214 20315 12757 170822 66481 54003 225058 71745 100038875 17925 100038991 18208 68028 225363 100043000 14026 67891 17690 100043295 18458 622534 13138 238217 14852 214230 16785 17973 666669 16870 100040021 16871 67025 12767 100043391 268902 668182 326622 241053 13176 18186 432502 16876 19087 19989 238276 11705 76808 20663 19899 67252 100043184 12331 19921 241656 19934 71436 18121 100043755 18643 18645 22323 16872 319195 67031 100043209 20564 68193 20562 621100 15399 19941 665189 666899 100042670 15519 100039316 22121 58234 100043876 100043893 100043423 100042986 20115 67281 54196 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 20450 12400 20452 16190 74325 15481 192160 13430 60365 53314 68134 192170 384783 19826 14165 66441 14389 17149 14472 24136 225207 18991 18424 14180 20664 14178 14179 21389 20674 192119 14175 14173 22063 109700 22065 16398 22067 22066 22068 14581 16194 14247 22022 12224 110794 12606 17364 12986 26946 16775 16776 16777 16779 16780 226519 14268 16782 16772 23928 16773 16774 22370 328440 19119 171506 227606 384452 17701 18509 84653 56184 17293 13389 18761 21426 20583 20111 107045 18717 226414 97541 17169 216443 18505 22631 13616 22629 105148 15254 231872 13614 66143 22771 18976 17199 433759 13618 16590 15221 12977 104458 11694 21386 85305 17203 20439 13722 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 96%190704 Oligomerization of connexins into connexons 14609 14619 14618 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs 12631 67268 67938 17904 11848 11852 11853 17880 19877 77579 71960 16885 16886 17886 19046 19878 329251 17931 18479 FORMATION OF PARAXIAL MESODERM%REACTOME DATABASE ID RELEASE 96%9793380 Formation of paraxial mesoderm 56436 13388 17463 57296 20422 26445 12387 26446 19172 19173 19175 21389 19177 18128 16842 26443 26444 270118 19170 18121 66413 59029 67089 14182 70247 103806 328572 12159 20997 333639 22416 84653 56184 17293 13389 12914 14534 13838 18519 21762 22123 16848 19179 19181 19182 23996 19664 19184 26440 19166 19167 26441 26442 69077 66997 23997 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription 328572 232232 20602 21372 18128 333639 79221 21402 56438 270118 81004 170787 26965 15185 667035 22190 70315 15184 15183 20185 21885 12914 15213 56233 51813 17869 14534 15214 21886 18519 15251 21888 208727 15205 15208 19664 433759 56198 264064 15182 103806 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle 193670 227619 54197 19089 192193 12317 14827 216440 269523 12330 667035 22190 67819 19359 116891 20338 109154 74126 66967 223455 57377 66597 320011 225896 23802 22644 19179 66435 108687 75841 217364 14376 59007 HIV TRANSCRIPTION ELONGATION%REACTOME%R-HSA-167169.4 HIV Transcription Elongation 68092 433702 20922 20833 68705 98053 13871 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 58202 17420 67923 12572 27224 13872 27632 20924 24116 23894 12455 14884 13716 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes 17685 17350 208836 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 240087 209357 66467 20020 231329 20021 69241 66671 17749 100043714 17420 12572 22059 13872 20924 23894 14884 14281 19364 11920 20922 20833 12189 67655 21399 107951 57314 114741 12454 211651 14088 11909 58202 107986 67923 27224 27632 24116 12455 72949 69131 13716 12649 16476 69562 18861 CELLULAR HEXOSE TRANSPORT%REACTOME DATABASE ID RELEASE 96%189200 Cellular hexose transport 56636 246787 20528 227659 19729 212980 56017 20525 117591 64452 109342 20537 20526 353169 435818 170441 230612 20527 72045 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 96%5688849 Defective CSF2RB causes SMDP5 12984 12982 20387 20390 20389 20388 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex 16785 57294 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 54709 100042807 98221 66235 27207 67097 670832 100039316 633683 20044 27050 667279 20085 668144 20084 382492 20055 75617 20115 27370 629957 76846 20102 100040298 20103 668668 667739 13665 66481 67204 225058 100038875 267019 26905 67941 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 96%168927 TICAM1, RIP1-mediated IKK complex recruitment 56532 11796 106759 12675 16150 16151 66105 667035 100041766 216080 22190 93765 66589 22034 142980 19766 11797 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 96%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 66105 667035 22190 59029 67089 70247 15251 53417 16475 100041766 13819 101543 112407 112406 29806 67923 21762 22123 19179 19181 19182 23996 19184 26440 19166 216080 19167 22346 71745 26441 26442 69077 66997 23997 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139915 Activation of PUMA and translocation to mitochondria 22062 209456 21981 211586 13555 22059 21781 22061 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 96%9025094 Biosynthesis of DPAn-3 SPMs 11684 11687 19225 11689 DASATINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669914 Dasatinib-resistant KIT mutants 16590 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 96%9620244 Long-term potentiation 640703 14799 14811 13385 18039 14810 53310 11472 13383 20779 23859 14812 14814 64011 14813 211323 12322 12323 108058 12325 14800 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 96%5579029 Metabolic disorders of biological oxidation enzymes 394433 320997 13115 17161 110115 13081 242585 13072 13074 21391 232174 13079 546726 71519 13078 13075 244209 13070 14262 14629 22017 13123 104086 68165 14149 11720 109652 14148 14598 269378 14854 75475 14630 394436 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates 74134 320997 13120 71519 545817 106648 631304 622127 100040843 13118 72054 56448 ASP-3026-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717264 ASP-3026-resistant ALK mutants 11682 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer 14184 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 96%8875513 MET interacts with TNS proteins 16412 319939 217169 15234 17295 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 96%451326 Activation of kainate receptors upon glutamate binding 18796 18797 14702 18795 14696 14697 14710 14699 66066 14700 14688 14708 14706 110637 640703 14704 14807 14806 14695 13385 14805 52589 53310 14693 13383 14809 64337 14709 14701 FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9607240 FLT3 Signaling 14389 16923 20491 12402 14783 11651 11652 20851 20850 20963 14256 667035 22190 19271 12576 14255 19247 14360 12988 54607 18176 20662 15461 56484 11352 17444 216233 15162 16818 18708 12125 77799 23797 18706 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 96%111996 Ca-dependent events 12326 19088 55984 19108 19087 19084 104110 12322 12323 108058 12325 432530 210044 26413 104111 18747 100039592 640703 224129 18753 11512 18783 11513 110355 11514 18575 11515 18574 18573 18749 207565 18752 18750 19085 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855229 IP6 and IP7 transport between cytosol and nucleus 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 96%69183 Processive synthesis on the lagging strand 68275 18969 18968 18971 327762 68240 18972 14156 19075 19076 19891 67967 16881 69745 18538 MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72172 mRNA Splicing 66053 66983 15381 19655 70616 68598 67959 20462 107701 67480 72047 68092 74326 67500 433702 75956 56031 80744 66101 70225 68879 320632 67418 212880 66585 22380 74351 54723 83486 19134 545085 66877 244672 238831 23983 24010 18521 20227 83701 74255 57905 67229 68479 70312 330361 66177 67797 67050 209416 76167 76522 22184 72654 20222 50996 28035 78372 72886 67225 18949 60321 67178 66492 71715 215051 66618 230596 70052 70767 67922 66070 66381 77644 66810 108160 319322 100034361 66801 237859 19205 68592 27967 68035 217207 76936 67471 69757 68988 208768 71702 76793 22668 68981 67684 20639 209003 229279 227707 101943 81898 67439 94315 20646 192159 53317 15382 53379 56258 59013 98758 11991 11834 15388 15387 66055 68816 50783 67197 67678 54633 66094 67465 69192 78651 27756 67285 66373 236732 67958 68183 76479 20624 66642 75062 27366 228005 28000 13204 100041953 76938 13207 233908 66125 64340 622469 225027 15481 67996 22608 51796 192160 71713 53817 233073 20382 110809 60365 20383 21681 68134 108014 192170 69207 19826 193116 66441 17149 100040029 107686 384091 666609 100040177 67010 68705 20641 98053 20638 66420 69833 67710 245841 69920 67332 20022 20020 231329 20021 72198 69241 17749 100043714 170791 20630 14105 20637 53607 56070 67039 72459 56194 100336 72935 13211 56215 51810 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome 13649 21802 20779 12223 14388 71920 94212 13874 15200 19303 11839 13645 18708 19247 12988 18706 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 96%9603505 NTRK3 as a dependence receptor 18213 12028 58202 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME%R-HSA-9927432.2 Developmental Lineage of Mammary Gland Myoepithelial Cells 11839 21802 13645 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta 18796 18797 14708 14706 14702 18795 14704 14696 14695 14693 64337 14709 14697 14701 14710 14699 66066 14700 14688 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME DATABASE ID RELEASE 96%9970672 FXIIa activates plasma kallikrein-kinin system 319178 319183 319182 319190 319149 319176 18793 319181 15077 232345 51788 72461 16678 385643 94175 319169 12261 625328 15267 78303 319188 58992 319168 15270 16621 319167 12258 624153 319186 382522 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 96%3065676 SUMO is conjugated to E1 (UBA2:SAE1) 100043429 56459 50995 20610 IRAK4 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5603041.4 IRAK4 deficiency (TLR2 4) 17087 117149 12491 21899 20193 12475 17874 14161 12229 434174 21898 24088 21897 20201 110135 20202 99571 266632 SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants 26395 26396 26413 26417 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 96%5688890 Defective CSF2RA causes SMDP4 12984 12982 20387 20390 20389 20388 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection 17913 246256 17973 17909 105855 242687 330319 76884 22612 11308 22324 17886 108100 12928 11461 101314 26413 26417 14360 22325 11350 12502 57257 140579 17096 330662 11465 15162 140580 20430 17918 76709 19353 73178 20963 12229 56443 80987 68089 67771 11867 56378 66713 74117 245880 14191 14083 22376 215280 68524 50884 17925 83767 17882 329165 CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.3 CRMPs in Sema3A signaling 26757 14159 18845 18186 65254 18844 18846 22240 56637 243743 12934 12569 12568 20346 12933 14360 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 18550 56316 19128 14058 14071 19123 14068 66901 14456 14061 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 96%3595172 Defective CHST3 causes SEDCJD 12111 29873 121021 13003 13004 53374 12032 13179 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME DATABASE ID RELEASE 96%9725370 Signaling by ALK fusions and activated point mutants 16367 12575 78798 268980 13666 108147 215114 19645 12211 19043 21402 56438 19084 14025 16364 11682 12047 70297 16153 18148 17886 26965 667035 22190 26413 26417 327826 16573 13433 19386 22059 238037 14939 67533 14268 16154 14235 22160 18646 108989 54167 232679 18708 18709 81910 76850 239528 18706 22330 74769 672511 236511 17246 13191 26420 20850 54721 59069 18412 14784 16477 217351 214150 16593 17210 69162 15170 380928 17454 26419 116849 12608 27267 20846 20848 16476 667739 107971 67300 433759 18803 21787 17698 22637 67160 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 96%9665247 Resistance of ERBB2 KD mutants to osimertinib 13866 59079 12539 15519 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 96%168142 Toll Like Receptor 10 (TLR10) Cascade 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 71481 667035 26416 211550 22190 17258 20203 26410 26409 20210 24110 26413 103583 257632 26417 26940 266632 26401 80750 223664 53791 107607 19094 69721 102626 231130 93834 270151 73699 11596 26395 67454 22059 240518 71966 110651 108960 20112 59025 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 12370 21770 22030 67245 26399 26400 18034 26398 26420 13712 26414 26397 17260 434174 66513 93765 66589 23939 22034 66724 68652 20111 11909 26419 12675 16476 18033 18035 18036 11820 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610780 Degradation of GLI1 by the proteasome 12234 56436 17463 57296 14632 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18747 21762 22123 18222 19179 18749 19181 19182 23996 19184 26440 19166 24069 19167 26441 16396 26442 69077 66997 23997 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 96%975576 N-glycan antennae elongation in the medial trans-Golgi 20451 53618 98388 14595 71665 103534 17309 56336 56386 16866 57370 53418 269181 56375 217664 241230 107895 12640 20443 68947 17158 20440 67569 20450 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 69912 13684 103468 19386 234865 54451 59015 69736 51786 94230 74320 21681 68188 54188 110379 66899 170762 108989 53319 231042 227699 223921 227720 445007 269113 66679 SIGNALING BY WNT%REACTOME%R-HSA-195721.7 Signaling by WNT 233833 18796 18797 14686 21415 20682 18795 232440 14681 12387 319149 20586 16842 11651 12389 11652 15077 66310 140858 12005 21752 213464 93840 20668 234130 13001 73016 13000 84035 100039026 228770 17869 103236 56811 20680 24117 14296 74499 207742 14160 20319 23808 20377 20187 20675 20677 212398 100683 107515 192199 68151 77578 68911 12006 67772 216869 56433 67087 30930 80288 16974 65114 13380 16973 329252 73739 72135 328572 73130 20679 68339 106042 239405 407821 21414 21416 103573 208846 72780 19354 12914 14797 640703 19055 19056 18018 19058 13017 13016 11789 170758 27373 93687 11848 56513 56438 57265 14697 22412 216795 14710 14699 66066 14700 22410 22414 22411 14708 14706 22409 14704 14695 21886 14693 21888 64337 14709 22417 14701 54198 14702 93735 14696 14367 14365 17283 14362 22415 11798 14366 22413 22416 22420 11771 22418 11772 14370 71770 22422 22421 14368 22423 14369 20890 14688 22408 21887 26554 18719 232910 11773 13542 13544 13543 67300 12757 360216 84092 68031 21951 74493 12322 18643 16438 16439 75410 53627 16440 73699 19052 105782 19053 66313 51792 226849 225849 26931 21770 26932 319152 56505 74325 214498 235497 21762 22123 19179 19181 19182 23996 19184 75788 18752 26440 19166 19167 26441 240756 26442 94253 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 72345 19177 20674 21402 26443 26444 19170 66413 26965 667035 22190 18751 59029 26409 67089 70247 21885 15267 319168 319167 76850 239528 319186 319178 319183 319182 81601 236511 319190 20671 12399 319176 319181 19353 213988 217351 56637 214150 17454 319169 22631 625328 78303 319188 15270 433759 26563 26564 22419 225600 18750 624153 19091 19092 18587 18588 382522 18099