S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-4361 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation 104923 70266 67870 67873 56369 L-CYSTEINE DEGRADATION III%BIOCYC%PWY-5329 L-cysteine degradation III 52637 246221 14718 L-GLUTAMATE DEGRADATION (VIA 4-AMINOBUTANOATE)%BIOCYC%PWY0-1305 L-glutamate degradation (via 4-aminobutanoate) 14417 14415 14645 ESTRADIOL BIOSYNTHESIS II%BIOCYC%PWY-7306 estradiol biosynthesis II 13075 13087 DOCOSAHEXAENOATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7606 docosahexaenoate biosynthesis III (6-desaturase, mammals) 56473 54326 68801 74147 56348 METHYLGLYOXAL DEGRADATION VI%BIOCYC%MGLDLCTANA-PWY methylglyoxal degradation VI 52815 GLUTARYL-COA DEGRADATION%BIOCYC%PWY-5177 glutaryl-CoA degradation 110446 110460 93747 270076 L-ASPARAGINE BIOSYNTHESIS%BIOCYC%ASPARAGINE-BIOSYNTHESIS L-asparagine biosynthesis 27053 PHYTOL DEGRADATION%BIOCYC%PWY66-389 phytol degradation 111175 11671 MENAQUINOL-4 BIOSYNTHESIS II%BIOCYC%PWY-7998 menaquinol-4 biosynthesis II 71707 SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%BIOCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism 114663 228550 55980 320404 69718 19062 212111 320634 104015 16330 16331 16329 16332 233011 20975 17330 242291 101490 19211 L-CYSTEINE BIOSYNTHESIS III (FROM L-HOMOCYSTEINE)%BIOCYC%HOMOCYSDEGR-PWY L-cysteine biosynthesis III (from L-homocysteine) 107869 12411 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7211 superpathway of pyrimidine deoxyribonucleotides de novo< i> biosynthesis 22171 171567 22247 69719 75533 56749 51797 110074 21915 55936 382985 18102 18103 79059 56520 54369 22169 66566 20135 66588 20133 MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-8171 molybdenum cofactor biosynthesis 268566 SEROTONIN AND MELATONIN BIOSYNTHESIS%BIOCYC%PWY-6030 serotonin and melatonin biosynthesis 216343 13195 21990 11298 ZYMOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6074 zymosterol biosynthesis 18194 15490 73166 98386 &GAMMA;-LINOLENATE BIOSYNTHESIS%BIOCYC%PWY-6000 γ-linolenate biosynthesis 56473 20216 233801 26458 272428 94180 328845 14081 MRNA CAPPING II%BIOCYC%PWY-7379 mRNA capping II 74157 234728 24018 67897 PEPTIDO-CONJUGATES IN TISSUE REGENERATION BIOSYNTHESIS%BIOCYC%PWY-8355 peptido-conjugates in tissue regeneration biosynthesis 23887 11687 17001 11684 14865 11689 625249 13479 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%BIOCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) 68603 14593 110196 110446 319554 110460 15360 192156 100040592 17855 15357 L-GLUTAMINE DEGRADATION%BIOCYC%GLUTAMINDEG-PWY L-glutamine degradation 216456 14660 L-TYROSINE DEGRADATION%BIOCYC%TYRFUMCAT-PWY L-tyrosine degradation 15233 234724 15445 14085 14874 NORADRENALINE AND ADRENALINE DEGRADATION%BIOCYC%PWY-6342 noradrenaline and adrenaline degradation 18948 12846 791260 26876 11669 17161 109731 11671 N< I>-ACETYLGLUCOSAMINE DEGRADATION II%BIOCYC%PWY-6517 N< i>-acetylglucosamine degradation II 245847 67980 26384 56174 L-HISTIDINE DEGRADATION%BIOCYC%PWY-5030 L-histidine degradation 71761 108156 15109 243537 14317 NADH REPAIR%BIOCYC%PWY-6938 NADH repair 100043349 246703 URACIL DEGRADATION I (REDUCTIVE)%ARACYC%PWY-3982 uracil degradation I (reductive) 64705 99586 103149 SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%BIOCYC%PWY-6371 superpathway of inositol phosphate compounds 18796 107650 18797 18798 103199 18799 72469 18795 18706 74769 18707 18711 18802 217837 74055 219024 114875 18717 27399 74302 84095 269437 104709 18803 228550 83493 234779 320404 76500 69718 72519 19062 75669 212111 327655 320634 75678 104015 320207 16330 18718 16331 52858 108083 16332 18704 233011 240752 20975 18705 17330 225326 18720 18719 19211 97287 67073 227399 18710 117150 271424 30955 18708 18709 224020 227733 269615 L-PROLINE DEGRADATION%BIOCYC%PROUT-PWY L-proline degradation 212647 19125 METHYLGLYOXAL DEGRADATION I%BIOCYC%PWY-5386 methylglyoxal degradation I 14651 109801 L-ALANINE DEGRADATION%BIOCYC%ALANINE-DEG3-PWY L-alanine degradation 76282 108682 ACETATE CONVERSION TO ACETYL-COA%BIOCYC%PWY0-1313 acetate conversion to acetyl-CoA 68738 60525 SPERMINE AND SPERMIDINE DEGRADATION I%BIOCYC%PWY-6117 spermine and spermidine degradation I 212503 228608 20229 69215 11754 L-TYROSINE BIOSYNTHESIS%BIOCYC%PWY-6134 L-tyrosine biosynthesis 18478 ACYLCERAMIDE BIOSYNTHESIS AND PROCESSING%BIOCYC%PWY-8042 acylceramide biosynthesis and processing 11686 26569 320997 23801 545975 21816 433091 HOMOCARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-421 homocarnosine biosynthesis 107239 UMP BIOSYNTHESIS%BIOCYC%PWY-5686 UMP biosynthesis 22247 69719 56749 GUANOSINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6608 guanosine nucleotides degradation 76952 22436 18950 14544 SUPEROXIDE RADICALS DEGRADATION%BIOCYC%DETOX1-PWY superoxide radicals degradation 20656 667310 12359 20657 MYO< I>-INOSITOL BIOSYNTHESIS%BIOCYC%PWY-2301 myo< i>-inositol biosynthesis 71780 114663 55980 AEROBIC RESPIRATION I (CYTOCHROME C)%BIOCYC%PWY-3781 aerobic respiration I (cytochrome c) 78330 68202 17716 17717 407790 17718 17719 17720 67003 22273 66694 100042918 67530 67273 70316 68198 66495 67130 75406 66416 68375 66108 104130 12858 66945 68342 12857 66377 17711 68197 227197 67184 100042503 17708 66046 17709 230075 17710 66916 67264 66218 54405 17991 66091 110323 66052 67680 66925 225887 100040287 12861 72900 239760 22272 66414 226646 624814 17995 17993 595136 623286 66445 17721 17722 12868 66142 12866 100041785 66152 17992 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis 227697 236082 57357 67422 52014 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-841 purine nucleotides de novo< i> biosynthesis 171567 75533 382985 18102 14450 68870 56248 108147 11565 100042069 23917 14923 11564 11566 231327 18103 237823 79059 78801 56520 67054 54369 11636 11637 229949 20135 635960 229363 20133 NAD SALVAGE PATHWAY IV (FROM NICOTINAMIDE RIBOSIDE)%BIOCYC%PWY3O-4106 NAD salvage pathway IV (from nicotinamide riboside) 69564 74080 226518 66454 225994 GABA SHUNT%BIOCYC%GLUDEG-I-PWY GABA shunt 14417 14415 14661 268860 214579 14645 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%BIOCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) 66171 110208 14381 UBIQUINOL-10 BIOSYNTHESIS (LATE DECARBOXYLATION)%BIOCYC%PWY-5872 ubiquinol-10 biosynthesis (late decarboxylation) 71365 71707 12850 56075 71883 217707 227683 52064 230027 GUANOSINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7228 guanosine nucleotides de novo< i> biosynthesis 171567 75533 382985 18102 100042069 23917 14923 18103 79059 56520 54369 20135 229363 20133 SERINE AND GLYCINE BIOSYNTHESIS%BIOCYC%SER-GLYSYN-PWY serine and glycine biosynthesis 108037 236539 100678 56433 20425 107272 PURINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7224 purine deoxyribonucleosides salvage 171567 14923 75533 18103 79059 13178 56520 27369 54369 18102 229949 THYROID HORMONE METABOLISM II (VIA CONJUGATION AND OR DEGRADATION)%BIOCYC%PWY-6261 thyroid hormone metabolism II (via conjugation and or degradation) 394434 13371 20887 13370 GLUTAMINYL-TRNA^{GLN< SUP> BIOSYNTHESIS VIA TRANSAMIDATION%BIOCYC%PWY-5921 glutaminyl-tRNAgln< sup> biosynthesis via transamidation 216456 14660 27053 VITAMIN K-EPOXIDE CYCLE%BIOCYC%PWY-7999 vitamin K-epoxide cycle 27973 69568 56316 18104 MELATONIN DEGRADATION I%BIOCYC%PWY-6398 melatonin degradation I 107141 81906 13087 13078 13077 71519 74134 18984 20887 PURINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7179-1 purine deoxyribonucleosides degradation 11486 18950 GLUTATHIONE-MEDIATED DETOXIFICATION I%BIOCYC%PWY-4061 glutathione-mediated detoxification I 23887 14862 14866 68312 76263 68396 16790 100042314 14863 14872 14871 14859 68214 56615 14874 211666 66447 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%BIOCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 108156 14450 ICOSAPENTAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8399 icosapentaenoate metabolites biosynthesis 11689 16993 19225 PUTRESCINE BIOSYNTHESIS I%BIOCYC%PWY-40 putrescine biosynthesis I 75986 242669 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%BIOCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II 12651 68671 99712 75320 28042 CARNOSINE BIOSYNTHESIS%BIOCYC%PWY66-420 carnosine biosynthesis 107239 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%BIOCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 PYRIMIDINE DEOXYRIBONUCLEOTIDE PHOSPHORYLATION%BIOCYC%PWY-7197 pyrimidine deoxyribonucleotide phosphorylation 171567 75533 18103 79059 21915 56520 54369 22169 18102 66588 PROTECTIN BIOSYNTHESIS%BIOCYC%PWY-8357 protectin biosynthesis 11687 11684 625249 L-LYSINE DEGRADATION (PIPECOLATE PATHWAY)%BIOCYC%PWY66-425 L-lysine degradation (pipecolate pathway) 23923 209027 19193 209692 12971 CHONDROITIN SULFATE DEGRADATION (METAZOA)%BIOCYC%PWY-6573 chondroitin sulfate degradation (metazoa) 77042 15586 74468 (S)-RETICULINE BIOSYNTHESIS%BIOCYC%PWY-6133 (S)-reticuline biosynthesis 22173 ATP BIOSYNTHESIS%BIOCYC%PWY-7980 ATP biosynthesis 11972 108664 57423 66144 66290 11958 11957 11964 72325 11966 100039636 11947 66335 11973 11949 11974 230649 73834 17705 11946 114143 66043 11975 11950 100041835 432676 100039108 246782 228033 227112 FOLATE POLYGLUTAMYLATION%BIOCYC%PWY-2161 folate polyglutamylation 14287 270685 108037 108156 20425 L-SERINE BIOSYNTHESIS%BIOCYC%SERSYN-PWY L-serine biosynthesis 236539 100678 56433 107272 L-ASPARAGINE DEGRADATION I%BIOCYC%ASPARAGINE-DEG1-PWY L-asparagine degradation I 104816 66514 ITACONATE BIOSYNTHESIS I%BIOCYC%PWY-5750 itaconate biosynthesis I 16365 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS%BIOCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis 231327 237823 14450 PYRIMIDINE RIBONUCLEOSIDES SALVAGE I%BIOCYC%PWY-7193 pyrimidine ribonucleosides salvage I 22245 68556 72269 80914 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%BIOCYC%PWY66-5 superpathway of cholesterol biosynthesis 74754 13360 235293 170738 14137 16987 14593 13595 110196 20775 319554 15360 192156 100040592 17855 15357 68603 18194 15490 73166 98386 110446 110460 PUTRESCINE BIOSYNTHESIS III%BIOCYC%PWY-46 putrescine biosynthesis III 18263 11847 PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY0-1295 pyrimidine ribonucleosides degradation 72269 22271 76654 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis 15356 110446 15360 69772 71911 D-GLUCURONATE DEGRADATION%BIOCYC%PWY-5525 D-glucuronate degradation 68631 67880 58810 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis 18796 107650 18797 18798 18799 72469 18795 18802 74055 114875 18717 84095 269437 18803 234779 18718 52858 108083 18720 18719 67073 117150 224020 227733 269615 ETHANOL DEGRADATION IV%BIOCYC%PWY66-162 ethanol degradation IV 68738 60525 11669 12359 11671 CARBON DISULFIDE OXIDATION III (METAZOA)%BIOCYC%PWY-7926 carbon disulfide oxidation III (metazoa) 13106 L-ISOLEUCINE DEGRADATION%BIOCYC%ILEUDEG-PWY L-isoleucine degradation 12040 66885 12035 12036 15108 110446 13171 110460 13382 93747 12039 GLYCINE BIOSYNTHESIS%BIOCYC%GLYSYN-ALA-PWY glycine biosynthesis 11611 268782 ARACHIDONATE BIOSYNTHESIS V (8-DETATURASE, MAMMALS)%BIOCYC%PWY-7725 arachidonate biosynthesis V (8-detaturase, mammals) 76267 56473 74559 SUPERPATHWAY OF GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7835 superpathway of glycosphingolipids biosynthesis 20450 20449 22234 14595 227671 14421 20440 54613 53625 14344 93961 14343 20451 57370 53418 20454 56375 108105 239559 26877 54218 26879 20444 56386 20443 HEME DEGRADATION I%BIOCYC%PWY-5874 heme degradation I 109778 394433 15369 15368 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%BIOCYC%PWY-6273 phosphatidylethanolamine biosynthesis III 27388 NEOLACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7841 neolacto-series glycosphingolipids biosynthesis 56375 108105 56386 20443 20450 22234 14595 20440 54613 53625 20451 57370 53418 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%BIOCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) 75540 234730 GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%BIOCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 218138 THIAMINE SALVAGE III%BIOCYC%PWY-6898 thiamine salvage III 29807 THYMINE DEGRADATION%BIOCYC%PWY-6430 thymine degradation 64705 99586 103149 S< I>-METHYL-5'-THIOADENOSINE DEGRADATION%BIOCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation 66902 NAD PHOSPHORYLATION AND TRANSHYDROGENATION%BIOCYC%NADPHOS-DEPHOS-PWY-1 NAD phosphorylation and transhydrogenation 192185 18115 CHOLINE DEGRADATION%BIOCYC%CHOLINE-BETAINE-ANA-PWY choline degradation 110695 218865 ADENINE AND ADENOSINE SALVAGE VI%BIOCYC%PWY-6619 adenine and adenosine salvage VI 11534 PLASMALOGEN BIOSYNTHESIS%BIOCYC%PWY-7782 plasmalogen biosynthesis 12651 67420 68671 55979 12660 13026 14712 228061 99712 236899 75320 407243 28042 330450 L-DOPA AND L-DOPACHROME BIOSYNTHESIS%BIOCYC%PWY-6481 L-dopa and L-dopachrome biosynthesis 22173 L-TRYPTOPHAN DEGRADATION XI (MAMMALIAN, VIA KYNURENINE)%BIOCYC%PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) 98256 71562 70789 266645 237320 107766 70266 209176 15930 23923 229905 56720 14719 209692 ESTRADIOL BIOSYNTHESIS I (VIA ESTRONE)%BIOCYC%PWY66-380 estradiol biosynthesis I (via estrone) 13075 15490 13087 15487 15485 114664 ICOSAPENTAENOATE BIOSYNTHESIS III (8-DESATURASE, MAMMALS)%BIOCYC%PWY-7724 icosapentaenoate biosynthesis III (8-desaturase, mammals) 76267 56473 20216 233801 68801 272428 14081 74559 SULFITE OXIDATION%BIOCYC%PWY-5326 sulfite oxidation 211389 HISTAMINE BIOSYNTHESIS%BIOCYC%PWY-6173 histamine biosynthesis 15186 GANGLIO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7836 ganglio-series glycosphingolipids biosynthesis 20454 20449 22234 54218 14421 20440 20444 56386 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 1 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7832 ABH and Lewis epitopes biosynthesis from type 1 precursor disaccharide 80908 26877 14344 93961 METHYLGLYOXAL DEGRADATION III%BIOCYC%PWY-5453 methylglyoxal degradation III 11677 13106 67861 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%BIOCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis 11720 232087 108645 PLASMALOGEN DEGRADATION%BIOCYC%PWY-7783 plasmalogen degradation 18606 68255 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY0-162 superpathway of pyrimidine ribonucleotides de novo< i> biosynthesis 171567 22247 69719 75533 56749 51797 55936 18102 18103 79059 56520 54369 22169 66588 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%BIOCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 69718 217837 75678 GLYCINE SERINE BIOSYNTHESIS%BIOCYC%GLYSYN-PWY glycine serine biosynthesis 108037 20425 OLEATE BIOSYNTHESIS%BIOCYC%PWY-5996 oleate biosynthesis 20249 171210 171281 171282 328035 C20 PROSTANOID BIOSYNTHESIS%HUMANCYC%15369 C20 prostanoid biosynthesis 64292 67103 19223 19215 54486 77219 21391 15446 12408 100043508 19224 96979 19225 105349 3-PHOSPHOINOSITIDE DEGRADATION%BIOCYC%PWY-6368 3-phosphoinositide degradation 83493 72519 19062 320634 104015 16330 64436 16331 269180 16332 234515 234129 20975 101490 97287 19211 219024 74302 ULTRA-LONG-CHAIN FATTY ACID BIOSYNTHESIS%BIOCYC%PWY-8041 ultra-long-chain fatty acid biosynthesis 106529 83603 56348 COENZYME A BIOSYNTHESIS II (EUKARYOTIC)%BIOCYC%PWY-7851 coenzyme A biosynthesis II (eukaryotic) 71743 106564 66812 RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-397 resolvin D biosynthesis 11687 11684 71932 11689 625249 ACETONE DEGRADATION I (TO METHYLGLYOXAL)%BIOCYC%PWY-5451 acetone degradation I (to methylglyoxal) 81906 13087 13106 71519 74134 ARACHIDONATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8397 arachidonate metabolites biosynthesis 23887 64292 11687 67103 17001 19223 11684 19215 14865 54486 11689 77219 625249 21391 13479 15446 100043508 19224 96979 71932 72054 319446 13110 16993 106648 19225 56448 11688 PROTEIN CITRULLINATION%BIOCYC%PWY-4921 protein citrullination 18602 18600 18599 18601 242726 L-PHENYLALANINE DEGRADATION I (AEROBIC)%BIOCYC%PHENYLALANINE-DEG1-PWY L-phenylalanine degradation I (aerobic) 18478 PHOSPHATIDYLSERINE BIOSYNTHESIS II%BIOCYC%PWY-7506 phosphatidylserine biosynthesis II 27388 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis 228550 320404 69718 19062 212111 320634 104015 16330 16331 16332 233011 20975 17330 19211 INOSITOL DIPHOSPHATES BIOSYNTHESIS%BIOCYC%PWY-6369 inositol diphosphates biosynthesis 76500 69718 227399 327655 75678 271424 27399 THYRONAMINE AND IODOTHYRONAMINE METABOLISM%BIOCYC%PWY-6688 thyronamine and iodothyronamine metabolism 107585 13371 13370 THIOREDOXIN PATHWAY%BIOCYC%THIOREDOX-PWY thioredoxin pathway 50493 232223 26462 15-EPI< I>-LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-393 15-epi< i>-lipoxin biosynthesis 11689 19225 ACETYL-COA BIOSYNTHESIS FROM CITRATE%BIOCYC%PWY-5172 acetyl-CoA biosynthesis from citrate 104112 KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis 67041 110446 69772 71911 2'-DEOXY-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%BIOCYC%PWY-7180 2'-deoxy-α-D-ribose 1-phosphate degradation 67689 66681 11670 72535 232449 ANANDAMIDE LIPOXYGENATION%BIOCYC%PWY-8056 anandamide lipoxygenation 11687 11684 11689 L-METHIONINE SALVAGE FROM L-HOMOCYSTEINE%BIOCYC%ADENOSYLHOMOCYSCAT-PWY L-methionine salvage from L-homocysteine 12116 238505 64918 SUPERPATHWAY OF MELATONIN DEGRADATION%BIOCYC%PWY-6402 superpathway of melatonin degradation 107141 81906 13087 13078 13077 71519 74134 18984 20887 17161 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%BIOCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA 266645 237320 209692 GLUTATHIONE-PEROXIDE REDOX REACTIONS%BIOCYC%PWY-4081 glutathione-peroxide redox reactions 14776 14775 67305 14782 625249 14778 NAD SALVAGE%BIOCYC%NAD-BIOSYNTHESIS-III NAD salvage 74080 226518 66454 59027 HISTAMINE DEGRADATION%BIOCYC%PWY-6181 histamine degradation 76507 140483 CDP-DIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-5667 CDP-diacylglycerol biosynthesis 67512 55979 110911 67216 102247 14792 74596 77582 14732 231510 52123 67469 28169 215456 68262 99010 225010 218121 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%BIOCYC%PWY-6405 Rapoport-Luebering glycolytic shunt 17330 12183 FATTY ACID &ALPHA;-OXIDATION III%BIOCYC%PWY66-388 fatty acid α-oxidation III 338521 56794 11671 GLUCONEOGENESIS%BIOCYC%PWY66-399 gluconeogenesis 14120 100043349 12183 14377 18655 21991 18663 68401 18648 56012 13806 18563 17449 17448 11676 14751 14121 13808 14447 13807 11674 230163 18534 14378 PHENYLETHYLAMINE DEGRADATION I%BIOCYC%2PHENDEG-PWY phenylethylamine degradation I 237940 11669 17161 109731 11754 11671 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%BIOCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) 66646 19895 21351 21881 VERY LONG CHAIN FATTY ACID BIOSYNTHESIS II%BIOCYC%PWY-7036 very long chain fatty acid biosynthesis II 106529 54325 56348 74559 ARACHIDONATE BIOSYNTHESIS III (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7592 arachidonate biosynthesis III (6-desaturase, mammals) 76267 56473 20216 68801 233801 26458 56348 272428 94180 328845 14081 74559 D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 69718 217837 &GAMMA;-GLUTAMYL CYCLE%BIOCYC%PWY-4041 γ-glutamyl cycle 23887 68252 14630 66054 75475 14629 14854 UTP AND CTP DEPHOSPHORYLATION I%BIOCYC%PWY-7185 UTP and CTP dephosphorylation I 51797 55936 66566 GLYCOGENOLYSIS%BIOCYC%PWY-5941 glycogenolysis 212032 15277 15275 110078 110095 19309 216019 66681 103988 232714 72157 L-VALINE DEGRADATION%BIOCYC%VALDEG-PWY L-valine degradation 12040 268860 12035 227095 12036 66948 58875 13171 104776 13382 93747 12039 ARG N-END RULE PATHWAY (EUKARYOTIC)%BIOCYC%PWY-7799 Arg N-end rule pathway (eukaryotic) 231713 235606 67877 76773 11907 18203 56307 75624 ASPIRIN TRIGGERED RESOLVIN D BIOSYNTHESIS%BIOCYC%PWY66-395 aspirin triggered resolvin D biosynthesis 11689 19225 L-ASPARTATE BIOSYNTHESIS%BIOCYC%ASPARTATESYN-PWY L-aspartate biosynthesis 76615 14718 OXIDIZED GTP AND DGTP DETOXIFICATION%BIOCYC%PWY-6502 oxidized GTP and dGTP detoxification 17766 GDP-GLUCOSE BIOSYNTHESIS II%BIOCYC%PWY-5661-1 GDP-glucose biosynthesis II 212032 15277 15275 216019 66681 103988 72157 MELATONIN DEGRADATION II%BIOCYC%PWY-6399 melatonin degradation II 17161 TRNA SPLICING II%BIOCYC%PWY-7803 tRNA splicing II 98404 66078 68045 66637 76265 28088 104721 68215 67106 381802 PYRIMIDINE DEOXYRIBONUCLEOSIDES SALVAGE%BIOCYC%PWY-7199 pyrimidine deoxyribonucleosides salvage 21877 22171 72269 13178 57813 PYRIMIDINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7184 pyrimidine deoxyribonucleotides de novo< i> biosynthesis 22171 171567 75533 110074 21915 382985 18102 18103 79059 56520 54369 66566 20135 20133 L-PROLINE BIOSYNTHESIS%BIOCYC%PROSYN-PWY L-proline biosynthesis 56454 69051 209027 4-HYDROXY-2-NONENAL DETOXIFICATION%BIOCYC%PWY-7112 4-hydroxy-2-nonenal detoxification 100042314 14859 PURINE NUCLEOTIDES DEGRADATION%BIOCYC%PWY-6353 purine nucleotides degradation 100042069 23917 107569 23959 230718 76952 11486 22436 18950 14544 L-CYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6292 L-cysteine biosynthesis 107869 11720 232087 269378 12411 108645 L-METHIONINE SALVAGE CYCLE%BIOCYC%PWY-7527 L-methionine salvage cycle 66902 11720 232087 104923 108645 20810 70266 67870 67873 56369 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%BIOCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation 20975 114663 242291 101490 55980 19062 212111 320634 104015 16330 16329 16332 2-METHYL-BRANCHED FATTY ACID &BETA;-OXIDATION%BIOCYC%PWY-8181 2-methyl-branched fatty acid β-oxidation 66885 BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway 20481 218441 11480 12167 12168 12156 17128 LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis 23887 17001 14865 11689 319446 13479 16993 PROGESTERONE BIOSYNTHESIS%BIOCYC%PWY-7299 progesterone biosynthesis 15497 15492 L-GLUTAMATE BIOSYNTHESIS%BIOCYC%GLUTAMATE-SYN2-PWY L-glutamate biosynthesis 14661 RETINOATE BIOSYNTHESIS II%BIOCYC%PWY-6875 retinoate biosynthesis II 19662 19659 22436 GLUTATHIONE BIOSYNTHESIS%BIOCYC%GLUTATHIONESYN-PWY glutathione biosynthesis 14630 14629 14854 DOPAMINE DEGRADATION%BIOCYC%PWY6666-2 dopamine degradation 12846 17161 109731 11671 MARESIN BIOSYNTHESIS%BIOCYC%PWY-8356 maresin biosynthesis 11687 11684 71932 L-ASPARTATE DEGRADATION I%BIOCYC%ASPARTATE-DEG1-PWY L-aspartate degradation I 76615 14718 GALA-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7840 gala-series glycosphingolipids biosynthesis 20454 53897 22239 SORBITOL DEGRADATION I%BIOCYC%PWY-4101 sorbitol degradation I 20322 PYRUVATE FERMENTATION TO (S< I>)-LACTATE%BIOCYC%PWY-5481 pyruvate fermentation to (S< i>)-lactate 16833 16828 16832 PUTRESCINE DEGRADATION III%BIOCYC%PWY-0 putrescine degradation III 67689 11670 72535 11669 20229 17161 69215 109731 11671 CREATINE-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6158 creatine-phosphate biosynthesis 12716 12715 12709 76722 QUEUOSINE BIOSYNTHESIS II (QUEUINE SALVAGE)%BIOCYC%PWY-8105 queuosine biosynthesis II (queuine salvage) 60507 106248 L-LEUCINE DEGRADATION%BIOCYC%LEU-DEG2-PWY L-leucine degradation 208982 15356 11992 72039 56357 12040 12035 12036 13171 13382 12039 78038 GLYCEROL-3-PHOSPHATE SHUTTLE%BIOCYC%PWY-6118 glycerol-3-phosphate shuttle 14555 L-ASPARAGINE DEGRADATION%BIOCYC%ASPARAGINE-DEG1-PWY-1 L-asparagine degradation 104816 66514 11593 14718 SEROTONIN DEGRADATION%BIOCYC%PWY-6313 serotonin degradation 20887 11669 17161 11671 ADENOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7219 adenosine ribonucleotides de novo< i> biosynthesis 11565 11564 11566 78801 11636 11637 229949 68870 635960 56248 ACYL-COA HYDROLYSIS%BIOCYC%PWY-5148 acyl-CoA hydrolysis 56360 70025 170789 ANANDAMIDE BIOSYNTHESIS II%BIOCYC%PWY-8053 anandamide biosynthesis II 225845 66727 27281 L-TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 98256 71562 70789 107766 209176 15930 56720 UDP-&ALPHA;-D-XYLOSE BIOSYNTHESIS%BIOCYC%PWY-4821 UDP-α-D-xylose biosynthesis 67883 22235 PHOSPHOLIPASES%BIOCYC%LIPASYN-PWY phospholipases 18796 18797 18798 18799 72469 18795 18802 74055 225845 66727 114875 27281 232889 18805 18806 269437 18778 18256 18803 26971 329502 234779 67452 271844 104759 237625 26970 665270 53357 26565 18783 18784 18782 18807 78390 66350 269615 EPOXYSQUALENE BIOSYNTHESIS%BIOCYC%PWY-5670 epoxysqualene biosynthesis 14137 20775 CARDENOLIDE BIOSYNTHESIS%BIOCYC%PWY-6032 cardenolide biosynthesis 78925 94224 CHOLESTEROL BIOSYNTHESIS I%BIOCYC%PWY66-341 cholesterol biosynthesis I 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 OPHTHALMATE BIOSYNTHESIS%BIOCYC%PWY-8043 ophthalmate biosynthesis 14630 14629 14854 14718 COENZYME A BIOSYNTHESIS%BIOCYC%COA-PWY-1 coenzyme A biosynthesis 71743 106564 66812 75735 211347 74450 SUCROSE DEGRADATION%BIOCYC%PWY66-373 sucrose degradation 11676 69983 16548 225913 11674 21991 230163 PRPP BIOSYNTHESIS%BIOCYC%PWY0-662 PRPP biosynthesis 75456 19139 110639 SUPERPATHWAY OF PYRIMIDINE DEOXYRIBONUCLEOSIDE SALVAGE%BIOCYC%PWY-7200 superpathway of pyrimidine deoxyribonucleoside salvage 22171 171567 75533 21915 18102 57813 21877 18103 79059 72269 13178 56520 54369 22169 66588 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%BIOCYC%PWY3O-450 phosphatidylcholine biosynthesis 12651 12660 13026 99712 236899 212862 SUPERPATHWAY OF L-TRYPTOPHAN UTILIZATION%BIOCYC%PWY66-401 superpathway of L-tryptophan utilization 78914 74080 226518 98256 66454 58810 71562 70789 266645 237320 107766 209176 15930 56720 13195 209692 21990 11298 216343 13087 110446 110460 93747 20887 270076 11671 107141 81906 13078 13077 71519 74134 18984 11669 17161 109731 67375 FATTY ACID &BETA;-OXIDATION (PEROXISOME)%BIOCYC%PWY66-391 fatty acid β-oxidation (peroxisome) 11430 113868 93732 20280 15107 15488 26458 74147 94180 15108 328845 93747 L-TRYPTOPHAN DEGRADATION VIA TRYPTAMINE%BIOCYC%PWY-6307 L-tryptophan degradation via tryptamine 58810 13195 109731 11671 TRNA CHARGING%BIOCYC%TRNA-CHARGING-PWY tRNA charging 212679 70560 27267 23874 224805 71984 226414 85305 97541 70791 22375 216443 234734 107271 20226 15115 105148 68915 230577 226539 69955 71941 381314 107508 102436 67417 109093 110960 70223 22321 353172 66590 272396 71807 244141 104458 70120 107045 PYRIDOXAL 5'-PHOSPHATE SALVAGE%BIOCYC%PLPSAL-PWY-1 pyridoxal 5'-phosphate salvage 216134 103711 N< I>-ACETYLGLUCOSAMINE DEGRADATION I%BIOCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I 245847 67980 26384 4-HYDROXYBENZOATE BIOSYNTHESIS%BIOCYC%PWY-5754 4-hydroxybenzoate biosynthesis 234724 SUPERPATHWAY OF PURINE NUCLEOTIDE SALVAGE%BIOCYC%PWY66-409 superpathway of purine nucleotide salvage 171567 75533 382985 18102 18950 11486 68870 56248 11821 15452 11565 100042069 23917 14923 11564 11566 18103 79059 11534 78801 56520 54369 11636 11637 229949 20135 635960 229363 20133 SPHINGOLIPID BIOSYNTHESIS (MAMMALS)%BIOCYC%PWY-7277 sphingolipid biosynthesis (mammals) 93898 70750 104725 20773 13244 268656 228677 PYRIMIDINE DEOXYRIBONUCLEOTIDES BIOSYNTHESIS FROM CTP%BIOCYC%PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP 22171 171567 75533 21915 382985 18102 18103 79059 320685 56520 54369 66566 20135 20133 UTP AND CTP DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7176 UTP and CTP de novo< i> biosynthesis 171567 75533 51797 18103 79059 56520 55936 54369 22169 18102 66588 SUPERPATHWAY OF CHOLINE DEGRADATION TO L-SERINE%BIOCYC%PWY66-414 superpathway of choline degradation to L-serine 108037 110695 20425 218865 74129 12116 TCA CYCLE%BIOCYC%PWY66-398 TCA cycle 20916 20917 11429 67834 18293 13382 66052 67680 66925 17449 17448 66945 170718 14194 78920 12974 15929 56451 N< I>1< SUP>-METHYL-N< I>3< SUP>-AMINOCARBOXYPROPYL-PSEUDOURIDINE-MODIFIED RRNA BIOSYNTHESIS%BIOCYC%PWY-8341 N< i>1< sup>-methyl-N< i>3< sup>-aminocarboxypropyl-pseudouridine-modified rRNA biosynthesis 68327 14791 FATTY ACID &BETA;-OXIDATION%BIOCYC%FAO-PWY fatty acid β-oxidation 20280 15107 52538 26458 13177 231086 94180 15108 97212 328845 93747 CERAMIDE DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY3DJ-12 ceramide de novo< i> biosynthesis 93898 70750 104725 20773 13244 268656 228677 ARACHIDONATE BIOSYNTHESIS IV (8-DETATURASE)%BIOCYC%PWY-7601 arachidonate biosynthesis IV (8-detaturase) 74559 ERYTHRITOL BIOSYNTHESIS II%BIOCYC%PWY-8373 erythritol biosynthesis II 20322 11522 LACTO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7839 lacto-series glycosphingolipids biosynthesis 20454 108105 22234 26877 20440 56386 14344 93961 L-SERINE DEGRADATION%BIOCYC%SERDEG-PWY L-serine degradation 257635 TETRAHYDROPTERIDINE RECYCLING%BIOCYC%PWY-8099 tetrahydropteridine recycling 72562 13180 SPERMIDINE BIOSYNTHESIS%BIOCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis 20810 TETRAHYDROBIOPTERIN DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-5663 tetrahydrobiopterin de novo< i> biosynthesis 14528 20751 19286 L-TRYPTOPHAN DEGRADATION (KYNURENINE PATHWAY)%BIOCYC%TRYPTOPHAN-DEGRADATION-1 L-tryptophan degradation (kynurenine pathway) 98256 71562 70789 266645 237320 107766 209176 15930 56720 209692 110446 110460 93747 270076 PROTEIN O< I>-[N< I>-ACETYL]-GLUCOSYLATION%BIOCYC%PWY-7437 protein O< i>-[N< i>-acetyl]-glucosylation 108155 76055 CYTOCHROME C< I> BIOGENESIS%BIOCYC%PWY-8145 cytochrome c< i> biogenesis 15159 RETINOATE BIOSYNTHESIS I%BIOCYC%PWY-6872 retinoate biosynthesis I 19662 19659 19378 11668 242285 216454 56847 ABH AND LEWIS EPITOPES BIOSYNTHESIS FROM TYPE 2 PRECURSOR DISACCHARIDE%BIOCYC%PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide 20450 80908 14595 20443 76969 14348 14343 57370 53418 CMP PHOSPHORYLATION%BIOCYC%PWY-7205 CMP phosphorylation 171567 75533 18103 79059 56520 54369 22169 18102 66588 SUPERPATHWAY OF PYRIMIDINE RIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7209 superpathway of pyrimidine ribonucleosides degradation 72269 64705 99586 22271 103149 76654 THYROID HORMONE METABOLISM I (VIA DEIODINATION)%BIOCYC%PWY-6260 thyroid hormone metabolism I (via deiodination) 107585 13371 13370 ICOSAPENTAENOATE BIOSYNTHESIS II (6-DESATURASE, MAMMALS)%BIOCYC%PWY-7049 icosapentaenoate biosynthesis II (6-desaturase, mammals) 76267 56473 20216 233801 68801 272428 14081 I ANTIGEN AND I ANTIGEN BIOSYNTHESIS%BIOCYC%PWY-7837 i antigen and I antigen biosynthesis 14595 53625 72077 14538 57370 53418 FATTY ACID &BETA;-OXIDATION (UNSATURATED, ODD NUMBER)%BIOCYC%PWY-5137 fatty acid β-oxidation (unsaturated, odd number) 13177 23986 GLYCOLYSIS%BIOCYC%PWY66-400 glycolysis 100043349 103988 212032 15277 15275 216019 18642 18770 56421 18746 18641 12183 18655 21991 18663 18648 56012 13806 11676 14751 13808 14447 13807 11674 230163 HYDROGEN SULFIDE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY66-426 hydrogen sulfide biosynthesis II (mammalian) 107869 12411 HUMAN MILK OLIGISACCHARIDES BIOSYNTHESIS%BIOCYC%PWY-8459 human milk oligisaccharides biosynthesis 56375 16770 14595 50935 20440 53625 14344 93961 72077 53418 INOSINE 5'-PHOSPHATE DEGRADATION%BIOCYC%PWY-5695 inosine 5'-phosphate degradation 100042069 23917 23959 76952 22436 18950 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%BIOCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I 22275 14151 19044 12892 MITOCHONDRIAL L-CARNITINE SHUTTLE%BIOCYC%PWY-6111 mitochondrial L-carnitine shuttle 78070 12896 57279 12895 12894 EUMELANIN BIOSYNTHESIS%BIOCYC%PWY-6498 eumelanin biosynthesis 22178 13190 22173 22063 FATTY ACID BIOSYNTHESIS INITIATION (MITOCHONDRIA)%BIOCYC%PWY66-429 fatty acid biosynthesis initiation (mitochondria) 71147 223722 257633 70316 ANANDAMIDE DEGRADATION%BIOCYC%PWY6666-1 anandamide degradation 14073 FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%ECOCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) 11532 13885 GLOBO-SERIES GLYCOSPHINGOLIPIDS BIOSYNTHESIS%BIOCYC%PWY-7838 globo-series glycosphingolipids biosynthesis 22234 239559 227671 26879 20444 56386 14344 93961 14343 TREHALOSE DEGRADATION%BIOCYC%PWY0-1182 trehalose degradation 212032 15277 15275 58866 103988 LINOLEATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8395 linoleate metabolites biosynthesis 71932 13850 384214 13849 THE VISUAL CYCLE I (VERTEBRATES)%BIOCYC%PWY-6861 the visual cycle I (vertebrates) 77974 19771 19662 235033 19659 17252 241452 19892 20148 79235 98711 19660 19682 19661 28200 ANDROGEN BIOSYNTHESIS%BIOCYC%PWY66-378 androgen biosynthesis 15497 78925 94224 13074 15487 105349 15492 GUANOSINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7221 guanosine ribonucleotides de novo< i> biosynthesis 100042069 171567 23917 14923 75533 18103 79059 56520 54369 18102 229363 RETINOL BIOSYNTHESIS%BIOCYC%PWY-6857 retinol biosynthesis 77974 19662 235033 19659 17252 241452 20148 79235 98711 15450 104158 67935 234677 63857 436059 69060 19660 28200 DOCOSAHEXAENOATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8400 docosahexaenoate metabolites biosynthesis 11687 11684 71932 11689 625249 19225 56448 3-PHOSPHOINOSITIDE BIOSYNTHESIS%BIOCYC%PWY-6352 3-phosphoinositide biosynthesis 107650 103199 18706 74769 18707 18711 18717 84095 104709 83493 75669 320207 52858 108083 18704 240752 18705 225326 18720 18719 67073 18710 30955 18708 18709 224020 227733 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%BIOCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II 212032 107652 15277 67980 74246 15275 26384 109785 54342 216019 14751 103988 4-AMINOBUTANOATE DEGRADATION I%BIOCYC%PWY-6535 4-aminobutanoate degradation I 268860 214579 CMP-2-KETO-3-DEOXY-D-GLYCERO< I>-D-GALACTO< I>-NONONATE BIOSYNTHESIS%BIOCYC%PWY-6140 CMP-2-keto-3-deoxy-D-glycero< i>-D-galacto< i>-nononate biosynthesis 216019 L-CYSTEINE DEGRADATION I%BIOCYC%CYSTEINE-DEG-PWY L-cysteine degradation I 12583 14718 STEARATE BIOSYNTHESIS%BIOCYC%PWY-5972 stearate biosynthesis 170439 26458 70025 56348 94180 328845 14081 171210 171281 171282 74559 &BETA;-ALANINE DEGRADATION%BIOCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation 268860 TRANS< I>-4-HYDROXY-L-PROLINE DEGRADATION%BIOCYC%HYDROXYPRODEG-PWY trans< i>-4-hydroxy-L-proline degradation 212647 56189 67432 14719 &ALPHA;-TOCOPHEROL DEGRADATION%BIOCYC%PWY-6377 α-tocopherol degradation 106648 DOCOSAHEXAENOATE BIOSYNTHESIS IV (4-DESATURASE, MAMMALS)%BIOCYC%PWY-7727 docosahexaenoate biosynthesis IV (4-desaturase, mammals) 56473 54326 68801 56348 LANOSTEROL BIOSYNTHESIS%BIOCYC%PWY-6132 lanosterol biosynthesis 16987 SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%BIOCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism 56632 67103 26458 94180 433323 328845 171168 14081 81535 54447 230379 11886 20698 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%BIOCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate 66681 11486 18950 PYRIMIDINE DEOXYRIBONUCLEOSIDES DEGRADATION%BIOCYC%PWY-7181 pyrimidine deoxyribonucleosides degradation 72962 72269 22271 76654 D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%BIOCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism 18796 269437 18803 234779 72519 18718 18797 18798 18799 72469 18795 97287 18802 117150 74055 219024 114875 74302 269615 ALLOPREGNANOLONE BIOSYNTHESIS%BIOCYC%PWY-7455 allopregnanolone biosynthesis 77337 83702 78925 94224 105349 SPERMINE BIOSYNTHESIS%BIOCYC%ARGSPECAT-PWY spermine biosynthesis 671878 FOLATE TRANSFORMATIONS I%BIOCYC%PWY-2201-1 folate transformations I 270685 108037 108156 216188 17769 20425 107747 665563 17768 100039707 238505 GLYCEROL DEGRADATION%BIOCYC%PWY-4261 glycerol degradation 14626 14933 235533 D-MANNOSE DEGRADATION%BIOCYC%MANNCAT-PWY-1 D-mannose degradation 110119 L-METHIONINE DEGRADATION%BIOCYC%METHIONINE-DEG1-PWY L-methionine degradation 11720 232087 269378 108645 ADENINE AND ADENOSINE SALVAGE III%BIOCYC%PWY-6609 adenine and adenosine salvage III 15452 11486 18950 REACTIVE OXYGEN SPECIES DEGRADATION%BIOCYC%DETOX1-PWY-1 reactive oxygen species degradation 69590 14776 75512 14775 67305 20656 667310 12359 14780 14778 20657 ADENOSINE NUCLEOTIDES DEGRADATION%BIOCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation 107569 23959 230718 76952 11486 22436 18950 ACETONE DEGRADATION III (TO PROPANE-1,2-DIOL)%BIOCYC%PWY-7466 acetone degradation III (to propane-1,2-diol) 81906 13087 13106 67861 71519 74134 L-CARNITINE BIOSYNTHESIS%BIOCYC%PWY-6100 L-carnitine biosynthesis 56752 170442 192289 20425 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%BIOCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) 228550 320404 69718 19062 212111 320634 75678 104015 16330 16331 16332 233011 20975 217837 LIPOXIN BIOSYNTHESIS%BIOCYC%PWY66-392 lipoxin biosynthesis 11687 11684 11689 625249 11688 TRIACYLGLYCEROL DEGRADATION%BIOCYC%LIPAS-PWY triacylglycerol degradation 69060 18947 16891 231871 16956 67717 15450 16890 116939 12613 66853 269060 CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%BIOCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) 94181 12764 50798 67311 CARDIOLIPIN BIOSYNTHESIS%BIOCYC%PWY-5269 cardiolipin biosynthesis 74451 66586 66461 L-DOPA DEGRADATION%BIOCYC%PWY-6334 L-dopa degradation 12846 CREATINE BIOSYNTHESIS%BIOCYC%GLYCGREAT-PWY creatine biosynthesis 14431 67092 UDP-&ALPHA;-D-GLUCURONATE BIOSYNTHESIS (FROM UDP-GLUCOSE)%BIOCYC%PWY-7346 UDP-α-D-glucuronate biosynthesis (from UDP-glucose) 22235 GUANOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7226 guanosine deoxyribonucleotides de novo< i> biosynthesis 171567 75533 18103 79059 56520 54369 382985 18102 20135 20133 FRUCTOSE 2,6-BISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY66-423 fructose 2,6-bisphosphate biosynthesis 270198 319801 18639 18640 170768 GERANYLGERANYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5120 geranylgeranyl diphosphate biosynthesis 14593 DTMP DE NOVO< I> BIOSYNTHESIS (MITOCHONDRIAL)%BIOCYC%PWY66-385 dTMP de novo< i> biosynthesis (mitochondrial) 22171 108037 ADENOSINE DEOXYRIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%BIOCYC%PWY-7227 adenosine deoxyribonucleotides de novo< i> biosynthesis 171567 75533 18103 79059 56520 54369 382985 18102 20135 20133 NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%BIOCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 78914 74080 226518 66454 67375 HEME A< I> BIOSYNTHESIS%BIOCYC%PWY-7856 heme a< i> biosynthesis 70383 MRNA CAPPING I%BIOCYC%PWY-7375 mRNA capping I 24018 67897 DI-HOMO-&GAMMA;-LINOLENATE METABOLITES BIOSYNTHESIS%BIOCYC%PWY-8396 di-homo-γ-linolenate metabolites biosynthesis 12408 PHOSPHATIDYLSERINE BIOSYNTHESIS I%BIOCYC%PWY-7501 phosphatidylserine biosynthesis I 19210 (4Z,7Z,10Z,13Z,16Z)-DOCOSA-4,7,10,13,16-PENTAENOATE BIOSYNTHESIS II (4-DESATURASE)%BIOCYC%PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) 56473 54326 68801 56348 74559 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%BIOCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I 74246 TERMINAL O< I>-GLYCANS RESIDUES MODIFICATION (VIA TYPE 2 PRECURSOR DISACCHARIDE)%BIOCYC%PWY-7434 terminal O< i>-glycans residues modification (via type 2 precursor disaccharide) 20450 14595 20440 53625 20443 72077 14538 57370 240119 53418 ETHANOL DEGRADATION III%BIOCYC%PWY66-161 ethanol degradation III 13106 68738 60525 11669 11671 ETHANOL DEGRADATION II%BIOCYC%PWY66-21 ethanol degradation II 68738 60525 11669 11671 2-OXOBUTANOATE DEGRADATION%BIOCYC%PWY-5130 2-oxobutanoate degradation 66904 17850 73724 110821 12040 13171 13382 12039 LACTOSE DEGRADATION III%BIOCYC%BGALACT-PWY lactose degradation III 226413 12091 70893 NICOTINE DEGRADATION IV%BIOCYC%PWY66-201 nicotine degradation IV 81906 13087 71519 14262 74134 55990 11761 14263 394433 226564 D-GALACTOSE DEGRADATION V (LELOIR PATHWAY)%BIOCYC%PWY66-422 D-galactose degradation V (Leloir pathway) 74246 66681 319625 14430 14635 72157 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%BIOCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II 212032 14584 107652 15277 15275 109785 54342 216019 14751 103988 14583 L-ALANINE BIOSYNTHESIS%BIOCYC%ALANINE-SYN2-PWY L-alanine biosynthesis 76282 108682 INOSINE-5'-PHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6124 inosine-5'-phosphate biosynthesis 11564 67054 108147 L-LYSINE DEGRADATION (SACCHAROPINE PATHWAY)%BIOCYC%LYSINE-DEG1-PWY L-lysine degradation (saccharopine pathway) 30956 110695 23923 209692 L-SELENOCYSTEINE BIOSYNTHESIS%BIOCYC%PWY-6281 L-selenocysteine biosynthesis 214580 20768 109079 20226 211006 71984 FATTY ACID &ALPHA;-OXIDATION%BIOCYC%PWY66-387 fatty acid α-oxidation 117147 26458 16922 56794 11671 GLUTAMINE BIOSYNTHESIS%BIOCYC%GLNSYN-PWY glutamine biosynthesis 14645 TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis 14593 110196 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%BIOCYC%PWY-5963 thio-molybdenum cofactor biosynthesis 68591 WYBUTOSINE BIOSYNTHESIS%BIOCYC%PWY-7283 wybutosine biosynthesis 100929 329504 209584 ANANDAMIDE BIOSYNTHESIS I%BIOCYC%PWY-8051 anandamide biosynthesis I 18778 18606 66727 27281 242864 56209 VALPROATE &BETA;-OXIDATION%BIOCYC%PWY-8182 valproate β-oxidation 66885 117147 110446 110460 93747 NAD DE NOVO< I> BIOSYNTHESIS%BIOCYC%NADSYN-PWY NAD de novo< i> biosynthesis 78914 74080 98256 226518 71562 66454 70789 107766 209176 15930 56720 67375 LONG-CHAIN FATTY ACID ACTIVATION%BIOCYC%PWY-5143 long-chain fatty acid activation 26458 94180 328845 14081 74205 THIOSULFATE DISPROPORTIONATION IV (RHODANESE)%BIOCYC%PWY-5350 thiosulfate disproportionation IV (rhodanese) 22117 2-ARACHIDONOYLGLYCEROL BIOSYNTHESIS%BIOCYC%PWY-8052 2-arachidonoylglycerol biosynthesis 114874 18795 231871 269060 ARSENIC DETOXIFICATION (MAMMALS)%BIOCYC%PWY-4202 arsenic detoxification (mammals) 11832 20531 64008 20516 20515 67768 20525 67674 18950 BUPROPION DEGRADATION%BIOCYC%PWY66-241 bupropion degradation 81906 13087 71519 74134 13088 PROTEIN S< I>-NITROSYLATION AND DENITROSYLATION%BIOCYC%PWY-7798 protein S< i>-nitrosylation and denitrosylation 11532 UDP-&ALPHA;-D-GLUCOSE BIOSYNTHESIS I%BIOCYC%PWY-7343 UDP-α-D-glucose biosynthesis I 66681 216558 72157 ASPIRIN TRIGGERED RESOLVIN E BIOSYNTHESIS%BIOCYC%PWY66-394 aspirin triggered resolvin E biosynthesis 11689 16993 19225 ORNITHINE DE NOVO < I> BIOSYNTHESIS%BIOCYC%ARGININE-SYN4-PWY ornithine de novo < i> biosynthesis 56454 SULFATE ACTIVATION FOR SULFONATION%BIOCYC%PWY-5340 sulfate activation for sulfonation 23972 23971 GDP-MANNOSE BIOSYNTHESIS%BIOCYC%PWY-5659 GDP-mannose biosynthesis 331026 14751 29858 54128 110119 69080 CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%BIOCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) 18194 74754 15490 13360 73166 235293 98386 170738 14137 16987 13595 20775 UREA CYCLE%BIOCYC%PWY-4984 urea cycle 11898 109900 227231 18416 GLYCINE BETAINE DEGRADATION II (MAMMALIAN)%BIOCYC%PWY-3661-1 glycine betaine degradation II (mammalian) 108037 20425 74129 12116 SULFIDE OXIDATION IV (METAZOA)%BIOCYC%PWY-7927 sulfide oxidation IV (metazoa) 211389 59010 22117 HEME BIOSYNTHESIS%BIOCYC%PWY-5920 heme biosynthesis 22275 17025 14151 11655 19044 11656 12892 15288 22276 PROPANOYL COA DEGRADATION I%BIOCYC%PROPIONMET-PWY propanoyl CoA degradation I 66904 17850 73724 110821 L-THREONINE DEGRADATION%BIOCYC%PWY66-428 L-threonine degradation 12040 13171 13382 231691 257635 12039 GUANINE AND GUANOSINE SALVAGE%BIOCYC%PWY-6620 guanine and guanosine salvage 15452 18950 CITRULLINE-NITRIC OXIDE CYCLE%BIOCYC%PWY-4983 citrulline-nitric oxide cycle 11898 109900 18126 18127 18125 SUPERPATHWAY OF METHIONINE DEGRADATION%BIOCYC%PWY-5328 superpathway of methionine degradation 12040 13171 13382 12116 12039 238505 14718 64918 211389 66904 17850 73724 110821 11720 107869 12583 232087 269378 12411 108645 TETRAPYRROLE BIOSYNTHESIS%BIOCYC%PWY-5189 tetrapyrrole biosynthesis 17025 11655 11656 15288 22276 MEVALONATE PATHWAY%BIOCYC%PWY-922 mevalonate pathway 68603 110446 319554 110460 15360 192156 100040592 17855 15357 TAURINE BIOSYNTHESIS II%BIOCYC%PWY-7850 taurine biosynthesis II 211488 106564 14261 ASCORBATE RECYCLING (CYTOSOLIC)%BIOCYC%PWY-6370 ascorbate recycling (cytosolic) 93692 14873 DIACYLGLYCEROL AND TRIACYLGLYCEROL BIOSYNTHESIS%BIOCYC%TRIGLSYN-PWY diacylglycerol and triacylglycerol biosynthesis 55979 67916 216152 13350 19012 231510 50784 52123 67800 67469 68393 28169 381925 215456 229791 68262 235044 99010 225010 218121 67512 67216 102247 14792 77582 14732 FLAVIN BIOSYNTHESIS%HUMANCYC%11070 flavin biosynthesis 54391 319945 D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%BIOCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 17330 69718 217837 CATECHOLAMINE BIOSYNTHESIS%BIOCYC%PWY66-301 catecholamine biosynthesis 13166 18948 13195 21823 7-(3-AMINO-3-CARBOXYPROPYL)-WYOSINE BIOSYNTHESIS%BIOCYC%PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis 100929 209584 TAURINE BIOSYNTHESIS I%BIOCYC%PWY-5331 taurine biosynthesis I 246277 12583 14261 ADENINE AND ADENOSINE SALVAGE I%BIOCYC%P121-PWY adenine and adenosine salvage I 11821 MALATE-ASPARTATE SHUTTLE%BIOCYC%MALATE-ASPARTATE-SHUTTLE-PWY malate-aspartate shuttle 17449 17448 14718 TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor 75788 12393 76630 19877 17977 72183 18519 15529 18744 12447 57258 17222 16478 66313 20481 20482 56440 12530 67804 20682 20692 56484 20742 26409 21417 21781 211586 26413 21808 26417 21809 21812 26419 21813 216080 100041766 66105 22337 26416 103573 76793 227720 75465 67068 54709 52563 217232 69150 11909 69957 14106 12234 12442 230597 12505 24136 218210 56458 26399 21803 21814 18751 18752 17869 12928 11651 216869 11835 11848 26397 11910 19650 19651 17126 17127 18708 18709 12927 18753 14083 12566 20869 22062 22059 12387 13163 328572 13982 13132 71770 16842 433759 21402 15481 26965 16476 15239 17128 56438 68015 12567 12571 12575 68999 22601 66513 13018 26754 20901 218441 26411 71728 12534 12914 386655 19303 104394 14281 13559 13805 19645 23871 12443 14030 54601 14225 269338 14272 14282 20683 97064 12189 272359 99152 52206 15378 15405 69260 21815 16477 16211 17130 17131 17258 17260 12705 18044 18045 18046 18102 56513 56371 59008 56317 228026 18854 19042 71978 19085 19087 75901 12389 BDNF%IOB%BDNF BDNF 18212 26419 18803 23939 56637 26420 110157 16367 20416 13712 19229 271849 384783 18211 56484 26413 26417 11651 CCR1%IOB%CCR1 CCR1 26416 19229 18753 12913 14083 12768 18033 19697 19303 20302 20303 20304 20306 20846 22637 14675 20779 26413 26417 LEPTIN%IOB%LEPTIN Leptin 16367 384783 54611 18754 26413 20528 13649 26417 20218 16452 14784 20683 20848 667739 17979 19247 16453 192157 26416 16410 16419 16846 18708 16847 18709 18753 14083 THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin 20848 56484 20416 233871 26413 17480 14388 26417 20851 16452 26395 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor 19273 71520 15461 67296 114715 114716 14936 16197 20662 56150 17179 17311 17342 21682 215280 22612 21933 54607 16590 56468 67300 15162 12703 20850 12984 14159 14191 26413 17096 12928 11651 26419 26416 18708 18709 11909 328572 16476 18751 18803 56637 110157 20416 19697 20846 20779 16452 14784 667739 19247 16453 20851 12929 13448 13685 56717 16331 13857 11350 14360 218397 14786 20111 18706 22376 58194 12402 208650 18750 CCR7%IOB%CCR7 CCR7 26419 12631 18803 56637 26416 19229 19697 56717 56484 56458 26413 12775 26417 11555 100039973 11651 100038965 WNT%IOB%WNT Wnt 22612 26409 11651 216869 26419 18504 19045 11848 18099 23988 22417 19052 18747 84095 320790 77578 20377 20319 18753 20664 22408 22413 22415 22418 22421 12387 14367 14365 12005 14362 14366 93687 16842 14368 21413 14369 14370 14371 16476 18751 18719 18752 84035 330938 21416 22416 84505 56637 12571 606496 19353 16480 54401 226970 13016 17125 13728 13542 13543 13544 13380 208846 67943 20378 231103 14734 192199 11789 12550 12443 16202 16971 16974 16973 18019 26563 26564 18750 FAS%IOB%FAS Fas 224105 50873 12362 320795 19877 11746 19090 12369 19106 66593 12370 72322 12028 12048 19687 20230 12122 12169 20807 56274 58231 12229 21454 12537 21841 21843 22029 22030 22031 26413 74153 22390 26417 12380 12366 12363 12368 223255 26430 56041 100042807 192656 14082 12633 17999 17193 26926 21945 98488 217232 26885 15170 16818 109333 56637 26395 14360 218397 17096 11651 18753 13163 93687 19353 26396 12043 17295 18810 22352 12367 11545 12371 19766 15507 333883 18570 19192 63958 66587 14084 27373 100039026 13001 67379 13347 21969 13665 75705 93692 11798 14102 14103 11857 17187 26408 15235 101706 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 22612 11651 11835 11848 17126 17127 18708 18709 18753 14083 22062 100039786 23844 12821 109620 13684 13844 13866 55948 16403 192897 16418 16773 16774 16776 16777 16779 16780 226519 16782 16785 19353 16367 19882 18479 20416 54401 74769 18707 30955 59079 384783 12015 20166 22627 22629 22631 18710 213435 18208 12476 20779 13649 14784 17295 18810 19247 22352 12367 13685 56717 11350 14360 18706 18750 NGF%IOB%NGF NGF 12912 327826 18759 13712 83945 26413 26417 26395 20683 HEDGEHOG%IOB%HEDGEHOG Hedgehog 22627 13363 24069 19014 75050 19206 15245 20423 319757 216869 19207 117606 70208 59024 110355 13548 18747 69792 264064 100041953 14451 269209 14632 14633 14634 16147 12387 GM-CSF%IOB%GM-CSF GM-CSF 12934 12465 14376 14827 59013 12051 20525 20740 22350 22612 15162 20850 12984 14159 26413 17096 26417 11651 26419 26397 26416 18708 18709 12927 15170 26399 21803 21814 18803 56637 606496 26420 110157 20416 13712 12015 19303 12912 20846 16452 14784 26396 20848 14388 20851 26395 12929 23921 19264 20112 22324 56324 14694 20844 57320 12675 16150 18643 18035 11757 12402 12981 20963 18750 12982 CCR9%IOB%CCR9 CCR9 26419 56637 26416 22350 225825 12769 16401 16421 17698 19684 20300 17123 12550 56458 26413 26417 11651 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK 110157 26416 18479 20416 13712 14083 20851 26395 12169 18127 17973 13449 21687 21846 20850 14786 14159 26413 26417 11651 26396 CCR5%IOB%CCR5 CCR5 19229 19697 20303 20304 20306 20846 12774 11576 20850 26442 20293 20292 26413 20296 12273 26417 12504 11651 14784 20848 12631 26416 18708 15170 12675 16150 18035 20963 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha 16367 384783 20846 22637 20850 12928 20847 11651 226652 20848 20849 667739 15975 15976 26397 18783 18761 26398 20852 16451 13867 73086 54721 18753 20851 12929 13685 56717 22324 75705 56458 26399 18035 12402 TRAIL%IOB%TRAIL TRAIL 12362 19090 12369 66593 12370 12028 12122 18033 19697 21933 12912 26409 20779 22030 26413 26417 11651 12366 12367 11545 26416 14082 19766 12633 16151 26926 71609 50883 13030 12070 100039026 15270 11783 12387 27056 17210 11920 18383 670717 12018 11798 22333 65111 22035 18035 12042 105787 12402 NOTCH%IOB%NOTCH Notch 18519 26413 26417 17127 328572 16842 433759 21402 26965 15205 21423 11820 17128 20602 56438 13389 16449 14357 56637 14199 16396 56381 59287 15213 140484 13388 17125 15182 19664 16450 16848 18033 17305 19697 18128 18129 18131 18132 18133 20466 18550 100039623 54485 50754 55927 433586 100042305 19164 16452 19165 16656 20848 19763 27401 21885 22632 208117 270118 18222 60406 66935 20185 103806 M-CSF%IOB%M-CSF M-CSF 20416 12370 19229 17342 20850 11651 14784 20848 19247 22352 14082 19766 18708 210710 12977 18753 12978 20851 14083 23872 360013 209446 19201 17444 16331 13429 16332 12402 EGFR1%IOB%EGFR1 EGFR1 12390 56455 109711 54366 11502 101320 29875 54126 22687 19134 73178 29806 208177 68481 53859 12702 232431 54132 13549 194590 66952 23942 14924 21873 225870 20970 98910 238130 17775 330914 26431 78388 50926 12928 11651 11848 26397 17126 17127 18708 18709 12927 18753 14083 12566 20869 22059 13132 71770 433759 16476 15239 218441 12534 19303 14281 20683 21815 12389 16478 26413 26417 26419 26416 56458 18751 18752 17869 18803 23939 56637 26420 110157 20416 13712 19229 384783 18033 19697 20846 20779 13649 20218 16452 14784 20848 19247 14388 20851 26395 12929 13448 13685 56717 11350 14360 218397 14786 20111 18706 58194 12402 208650 18750 15461 20662 16590 67300 12703 20850 17096 12631 606496 19353 16480 54401 226970 13016 12550 26396 12043 17295 18810 22352 12371 19766 333883 11746 17999 15170 16818 109333 12821 109620 13844 13866 192897 18479 74769 18707 30955 59079 12015 22631 18710 12912 327826 18759 110355 13548 20112 22324 56324 20844 18643 18127 17973 13449 20847 16451 13867 73086 54721 105787 11820 16396 13429 16332 229615 12606 72993 227753 18760 19211 234779 100040260 20971 22325 12558 11308 12560 18571 71943 545878 24045 59026 74117 66713 15259 51789 12568 14251 74326 236576 24063 24064 57783 21787 67938 57257 108100 12608 24105 20499 26405 229709 19765 20867 399510 56460 69710 232910 12757 73379 19261 12988 216810 13014 12388 218518 74256 244418 11771 13205 13209 53310 330662 13511 13628 13642 13645 13836 208643 13710 13714 13043 13806 56205 13835 13838 270190 13845 13846 13860 13858 11657 11674 240753 13855 229285 26936 286940 14252 98432 224650 23943 209039 105782 22378 80794 14302 235406 228136 104831 20399 19253 18938 14609 11352 26377 69178 19285 14783 50915 216963 15258 75454 232906 26934 11740 13854 16952 12306 15194 215114 15382 628438 11804 16337 16400 16412 11836 67859 11843 110308 16687 110310 16691 16667 16668 16828 11855 16835 210126 109904 26401 26406 26407 17709 17886 17920 18003 11928 23980 50932 20403 13196 11949 67941 50766 72621 18596 54135 72201 18607 11431 18648 240752 18738 18746 67451 18805 18806 22038 74155 67760 54473 109135 171463 212139 71889 216190 235542 74255 170643 321022 230837 108079 19084 26362 18762 66898 23938 26400 19108 208618 93742 66166 76179 140721 20459 19246 19248 19262 19267 19268 19272 19279 58235 110078 13859 271457 64143 19730 245688 100043257 11461 19734 666899 667618 667279 110651 67097 20194 20195 20239 394252 20969 53378 140579 71514 56726 20404 20408 230126 319939 381126 114479 20617 107686 20663 109552 109880 20909 11491 22042 21881 21894 21961 22051 22323 22330 108705 66395 244895 640703 60595 24066 319152 223650 231002 21346 29815 69538 239250 20324 17974 226419 194655 226250 217169 72828 227937 107435 30794 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor 12393 12362 17977 12369 18519 12370 12447 12530 12537 56705 12572 107951 56424 17978 81601 108767 12539 217127 13144 56710 13195 14797 11622 104156 14200 56406 192176 56218 14375 30051 68098 75273 11739 98053 68705 14884 223870 19183 15375 15469 14828 15519 16195 56637 11863 75352 17246 53610 18813 18477 57314 59004 18986 101700 214230 328365 12017 57782 19697 170758 19384 19822 18193 77627 225115 21804 20779 232286 22025 22026 22027 13649 22196 22353 107823 22596 20848 22668 627557 12317 17979 268903 52915 22294 23957 56469 12445 66671 107321 56736 12531 14694 57320 11651 11835 19045 17127 18708 12387 13163 328572 13982 433759 21413 15481 16476 17128 20602 19303 20466 19645 12443 20683 12189 12367 11545 15507 21815 21969 229615 12606 72993 227753 18760 19211 12389 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 20848 14388 14255 14389 11909 12912 12606 20850 26413 17096 100040260 26417 12402 16476 208650 11651 CD40%IOB%CD40 CD40 26419 20848 26420 16453 26416 18708 26395 16818 14360 12675 16150 14191 26413 17096 234779 18035 26417 16476 20963 11651 17869 TNFSF3%IOB%TNFSF3 TNFSF3 19698 18033 18034 19697 21937 21938 22033 16992 17000 16994 22030 22031 18035 16476 ID%IOB%ID ID 21416 11910 19650 19651 13712 17127 12566 19645 13713 13714 15901 15902 15903 15904 17877 15205 17927 18507 21423 19185 G-CSF%IOB%G-CSF G-CSF 12576 12700 12985 12986 14319 16188 18778 19696 20416 667310 20977 107939 12702 20846 15162 20850 18759 26413 17096 26417 16452 11651 14784 20848 19247 26416 16451 54721 20851 14389 12566 27373 16818 16331 20111 12402 20963 EPO%IOB%EPO EPO 606496 110157 15163 384783 20393 12015 319183 18127 56484 20850 54601 26413 26417 16452 11651 26396 109880 20848 19247 73086 14388 20851 26395 12929 23921 56717 22324 13857 56458 16476 20963 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma 110157 15395 15900 15979 16362 16363 19094 20375 20846 12608 20850 26413 13649 26417 12928 16452 11651 26419 20848 18783 18761 26416 20852 16451 12929 234779 12402 TNFSF1%IOB%TNFSF1 TNFSF1 16151 19698 18033 18034 19697 21937 21938 22033 16992 17000 230979 22031 18035 16476 11651 TNFALPHA%IOB%TNFALPHA TNFalpha 320795 12369 12370 53859 12122 22029 22030 22031 12366 107951 14082 12539 12633 56710 100039786 192176 15519 22627 22629 22631 12912 22026 22196 19698 18034 21937 21938 22033 14694 12675 16150 18035 20963 12051 19696 14886 11797 15516 16535 100039592 16648 16709 17218 17220 11651 26403 76784 18036 18037 20018 18567 18616 18637 245841 100043714 67857 73086 19173 19179 16151 19181 18753 71609 19182 70247 21762 22123 17463 66997 23997 228775 19708 77045 67891 432502 27207 433759 57751 21402 80859 27215 26965 64424 16476 20586 20587 20588 68094 57376 21926 21929 22034 22628 22682 66513 231130 236733 26754 20017 224619 15182 18201 230233 26572 56456 12914 12905 21934 12455 70834 233406 53376 17164 19645 211550 50797 21941 50754 226525 67384 20016 22032 56489 73174 66413 23881 227648 216150 21353 15185 72416 71833 56399 544963 333654 18789 56532 26410 446099 17846 109658 11652 14113 211651 76589 19414 14229 68652 103583 18854 16650 11647 66724 20019 56407 56312 12389 12091 20340 71966 69721 56480 26409 26405 26413 26417 26419 100041766 66105 26416 13205 12234 26399 26420 18033 19697 20846 20779 13649 19247 14388 13448 26401 26406 20850 18762 23938 666899 54401 13728 12367 19766 15507 14084 100039026 GDNF%IOB%GDNF GDNF 17295 19713 21823 110157 12532 19229 110651 12927 14388 14083 12534 26395 13448 19303 14360 18035 16476 12928 26396 TNFSF8%IOB%TNFSF8 TNFSF8 18034 19697 12051 19696 22029 21941 26413 22031 19698 11651 18033 CXCR4%IOB%CXCR4 CXCR4 14674 13983 23880 14677 26385 15894 16414 16428 16822 16885 12778 17973 20315 21785 22329 12767 56484 59025 12774 26413 17096 26417 12928 20847 216869 20849 12631 11848 26397 18708 18709 12927 18753 14083 15170 16818 15481 18803 56637 19353 54401 13712 19229 12015 18033 19697 19303 12912 20846 22637 20779 13649 16452 26396 20848 667739 19247 16453 20851 26395 12929 13448 19264 20112 16331 22324 14360 218397 12675 16150 22376 18035 234779 100040260 20971 12402 22325 208650 CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway 19225 18021 54720 16476 640703 56398 18018 18019 14281 104248 12981 16184 16183 15978 14103 53901 21947 381319 18986 14283 238276 14225 16477 16189 18747 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling 16476 20687 18519 12912 328572 17131 20466 14462 12567 226519 12566 228839 17869 15481 14815 20683 17977 75901 245688 19650 17978 14106 56484 17260 56458 16419 12579 21815 15378 13390 14836 60406 16191 12575 11835 12914 11909 17927 11651 15228 20467 20482 22337 20481 21781 13982 18091 15182 433759 13559 76793 104394 21423 15977 12843 94112 59004 17187 54601 14534 18787 17126 17127 17128 100041953 20185 12608 209446 22642 19646 12393 13016 11910 12399 16153 12400 54123 12705 229615 14281 IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events 16173 16171 257630 18033 18035 20846 21926 17523 20849 20848 209590 329244 12702 93672 16452 16182 83430 16176 16400 20293 18126 16174 12501 54721 17329 18708 19697 16161 16160 18706 11686 16193 12504 16183 330122 15978 20850 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression 433759 56469 103573 208727 22196 19384 17344 17246 19386 OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events 18720 53859 16202 16476 57257 26419 19353 16416 26413 19878 26417 19229 11848 12505 12675 16410 17390 26401 18792 17395 227753 18033 18035 18708 19697 14281 18706 12927 20963 20750 ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events 17128 26413 17131 26417 21813 13001 17129 21803 55994 11477 11480 12389 11481 12168 11482 17125 19045 13805 15901 21909 12165 16323 216869 21809 21812 14225 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase 16367 20779 14083 16476 76829 26419 19353 12912 26413 26417 11848 17973 19247 20662 18708 15461 14573 14783 14786 18706 13448 14784 623279 12928 58234 18750 19713 14388 384783 20416 327826 19303 109905 12927 14585 114255 18747 218397 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events 20969 12833 12832 26413 12215 12815 26417 12814 12831 94216 12830 83995 17393 15234 12361 20304 17395 14170 17295 12829 12828 12826 21803 12825 12824 64654 15442 12842 19035 16776 53378 14186 12836 12835 14184 12834 12843 18747 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation 18754 240057 18176 16854 240168 56715 18015 640703 20662 18751 15461 54153 19395 12323 16852 225870 14784 18762 233046 74055 69601 18750 20663 20130 19415 19419 114713 19417 19418 16653 218397 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling 20877 625328 16319 IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events 12703 20292 16186 16451 16453 12048 16416 15361 16165 16164 16992 15170 17863 16331 17864 20295 14159 11687 16190 20683 23871 56717 12053 18703 13449 16364 26416 245195 20344 20375 13654 18390 14128 21786 56468 21838 11846 16191 66596 11628 20851 12402 547253 20852 11651 14784 384783 12843 20416 16367 12608 16153 12842 12702 16452 18708 18706 20850 21947 16189 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K 16186 16451 16453 19353 12048 17863 17869 56717 18033 56484 11651 15519 19247 16185 640703 20662 667739 18708 20597 19697 12043 16818 13669 18706 21752 14784 18762 22234 16184 208449 16183 14389 13555 20416 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling 16186 16451 16453 11848 19247 16185 20662 15461 16818 14784 14389 232906 16001 14388 16000 107971 20416 18127 327826 18049 21687 18591 16911 16195 16194 16367 11600 22339 14677 15979 13645 18205 78405 18596 17356 94212 13649 15529 16542 110157 18211 18212 18213 14679 12064 26395 26396 20846 16452 18176 18708 18706 16193 16184 16183 15978 16653 18747 NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network 54720 20185 328572 12393 13016 17863 16542 17977 225182 14465 108058 14463 15251 103806 20602 20848 56381 22160 11545 12576 15214 16452 18128 11863 17172 22632 19645 11835 21885 12914 15205 19213 17927 14600 99982 14387 19664 14460 55927 15213 270118 11925 12504 433759 13555 21423 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions 16420 16398 16421 241226 16411 213119 16416 16412 16414 16410 16419 16400 104099 381924 16407 16408 16409 16399 320910 16401 16403 16402 16404 319480 192897 109700 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events 19046 19878 18817 228730 236930 11848 17931 20878 22390 19324 218294 269582 229841 72119 103733 99412 67141 107995 72415 20843 12531 67629 13605 12532 12235 56371 12234 16563 19348 19052 51792 100043703 18479 74498 78177 233406 71876 103583 67052 12534 18221 77744 12236 16319 BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events 17535 22195 18538 27354 22059 235559 100040608 12021 72775 19361 12566 225182 66105 22596 211651 14088 14087 14030 67030 11920 14375 12189 67337 60534 12447 19360 19090 S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway 14679 14677 14687 94226 11848 14673 14681 14678 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma 20779 12912 18211 55948 54401 18753 22065 193034 216439 12015 12443 18803 12326 56484 13653 12322 100039786 22628 22627 22631 22629 18607 56637 18176 11651 20662 18708 15461 18706 14784 20850 14388 20416 18049 16653 IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 16476 26419 16173 21803 20849 20848 16182 14969 14968 57765 12500 12502 12914 16362 16174 12503 12501 18646 16163 104156 12487 12519 12524 14281 26420 16184 12504 16183 15978 17344 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling 22352 23980 215387 67455 71819 16765 19047 28114 21770 107589 242521 11848 20878 72415 12235 19348 67052 26554 70099 19167 14211 12419 11799 52276 54204 26934 12615 13346 320165 14020 20877 68298 625328 73804 218397 16319 18148 NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events 20779 14083 19353 26413 26417 11848 18208 17909 69635 13176 330662 107449 14360 22612 26395 107448 216439 26396 73178 18738 17755 18803 22253 140580 223435 12322 18479 17973 18708 18706 12927 S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway 14677 26413 26417 14687 11848 94226 14673 14681 14678 14679 18803 13611 14674 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events 26395 26413 30955 18576 104709 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network 19225 328572 20466 14462 17863 17869 15481 20683 23871 20375 18712 68652 11906 11486 545878 12575 12490 17217 12914 67155 17311 17927 12418 17120 12571 21426 15461 17132 12043 14863 20481 56463 12757 19374 16841 19152 12346 66513 12368 232087 18507 26409 12843 22761 17878 12578 16842 23872 67738 16790 15258 67972 11796 12978 20185 16590 12608 12847 11541 19208 51788 50701 12427 21849 18099 29875 18674 64050 19055 229615 12609 12606 22408 12443 17523 12576 18176 15205 14460 12504 22196 16653 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling 20779 14083 19353 26413 26417 26395 13845 73178 13844 270190 22041 104015 13429 215449 13643 13642 13641 13640 16443 26921 545156 19877 13846 18176 18479 17973 18708 15461 14786 18706 14784 12928 20130 20416 19303 109905 16653 218397 FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway 20779 11796 26419 12675 26401 26416 18607 14082 19687 12229 14102 67300 11651 12122 12367 22350 18708 20597 16150 72393 74769 26420 26399 18706 26400 12370 16151 19766 19094 14103 11797 26414 12633 20963 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events 20873 20620 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway 21937 114774 11796 67384 18590 26419 13645 228355 229317 26926 26413 12028 58994 26417 18201 11886 26398 13033 110157 670717 12905 17869 26401 18753 26395 26396 18033 12015 18035 21926 26921 14082 19645 11651 12122 20597 19697 12043 18762 12370 19766 16000 56632 71609 22030 23992 19106 16706 ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling 20779 22195 21770 19229 14773 21823 18796 18753 14360 17096 22612 19144 15162 50873 12015 12143 30931 67847 57320 22223 13162 56424 100039026 14191 20617 18805 18806 109731 16818 14225 20963 ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway 12234 20779 12051 19696 216869 18708 16150 19697 16818 18706 18033 18035 26416 20963 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway 18720 16476 26419 16412 19878 11848 26398 17931 12576 18805 18806 19877 105243 320795 109333 11909 20404 320271 14064 22350 18719 20807 22330 20544 14281 26399 56513 11459 18762 29857 21894 12631 16007 223701 19211 18717 19684 17698 13367 17906 16885 12704 16886 26397 SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B 16416 11848 14360 22612 17096 15162 12143 12389 14191 20851 11651 16818 13448 14784 12928 20416 18591 16367 12977 20779 64177 19246 12978 12991 13645 12988 14131 12333 18596 50490 19116 24064 13649 16334 16846 16847 16797 19109 14158 22166 16337 12558 22608 20848 12702 16452 54721 18708 18706 20850 16399 12927 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events 20779 16398 26419 16412 26413 12028 26417 11848 15529 17390 12361 18753 14170 385643 13844 14268 60409 16774 21803 57916 269587 64654 16772 12390 14694 53378 14186 14184 18015 12367 22350 15461 12981 18747 218397 RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway 320139 18176 26413 26417 18751 15461 110157 14281 26395 18750 16653 26410 109880 13712 ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network 16476 26419 12048 12912 328572 26413 26417 12567 17390 21823 18792 26416 11846 11909 12043 13982 18750 12189 16334 11910 12400 12443 12702 20724 21808 83430 20174 18218 19017 19645 63953 18126 18595 15205 26914 20339 18015 16478 81703 13008 15132 12123 14281 26420 12428 26554 71355 81601 16193 19252 240672 15978 19094 13198 11423 13197 18986 16477 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling 13837 20779 13835 13637 57257 13636 53972 13836 13638 11848 14360 17096 22612 15162 12143 18803 30955 104709 13640 14191 19877 12402 16818 12928 442801 12568 12929 13842 13840 22325 13841 13839 13838 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I 21937 18519 328572 68346 17131 75387 20466 14461 27374 56233 15185 23942 15184 30795 64384 75788 70465 93759 216848 245688 232232 19016 17191 107932 64383 21422 22025 170787 229512 70315 50721 12234 209011 234366 60406 17119 79221 15183 229542 12914 17192 20467 15182 433759 22761 17187 100041953 20185 19646 18033 18035 21926 20602 20848 22632 19697 14460 103573 208727 22196 19384 19386 18747 ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events 18102 16398 105504 20528 241226 211446 213119 16412 16334 16410 18805 18806 16400 216859 67300 211914 12876 53413 70834 22319 30948 11555 12000 12387 20336 104099 30957 69940 12550 56044 107371 18717 16593 22095 16401 12385 16403 11845 16402 11607 16404 12388 319480 66482 13430 109700 24044 FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling 26419 93687 18519 27401 214897 328572 64143 19651 18817 12359 20393 20656 15235 12566 12675 252870 14377 55948 22682 54401 67731 12125 70425 93759 103236 12053 27373 104318 56484 56458 100039786 22628 22627 22631 12576 22629 12914 11651 16150 26420 12387 14103 56044 103573 26414 13197 19384 54601 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway 14676 14677 14687 94226 14673 14681 14678 14679 14675 17250 81535 14739 13611 56632 14672 14674 14682 20397 20698 13610 13609 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt 20779 20528 12048 12675 110157 55948 54401 56717 12015 56484 56458 100039786 22628 22627 22631 12576 22629 18607 210789 56637 78757 16646 56716 12575 606496 12371 23797 227743 11651 15519 11652 26408 54601 18747 19090 E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction 18102 20779 16421 19353 17356 11848 29875 12443 215449 11651 21872 18708 76884 107746 11767 13383 18706 12387 242687 21844 226541 12928 16480 16407 12550 13043 50884 11308 18717 12385 11845 109905 22325 12388 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family 110355 226861 21808 20423 19227 14451 13363 14633 216869 19206 11651 18708 18706 57810 16976 15245 117606 19207 14725 20460 16147 319757 POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle 20873 12795 18817 20620 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway 18720 16476 26419 19353 68089 67771 26398 26403 11867 56378 66713 74117 26401 11855 224105 18796 13058 241275 192662 13057 108100 101314 26416 17970 76709 83767 329165 71893 17969 237038 404710 18479 11909 18719 12387 12928 12631 12550 18717 12385 16885 26397 29875 20848 76884 26420 26399 26400 242687 20850 50884 11308 26934 12927 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones 14686 12790 76376 19682 245650 243923 14695 77974 30952 78600 14697 170735 107477 14913 24013 19892 19739 79235 110855 14710 14919 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity 18102 20403 73341 227377 57257 109904 53972 219140 319899 216963 75974 11789 192662 18803 16443 70497 210293 236915 26934 29815 54126 19765 52666 22325 71972 228359 17207 14163 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network 22339 13636 328572 14254 17387 67923 18655 16542 112407 112406 20525 26357 11792 22346 20683 23871 16341 93759 20893 18999 17684 18174 13856 13819 14297 319594 11540 22160 13712 11863 12914 18787 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity 16476 26419 18519 328572 14461 26398 56233 14815 17977 93759 17978 26416 56458 22025 19696 11835 12914 67155 320795 15519 433759 20779 12606 13653 14694 20588 11614 52915 217127 59035 56637 21848 18585 30051 20181 20183 20182 223870 22026 66884 57376 50528 15408 110147 26399 68098 15502 81601 18986 17246 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway 16451 16476 18595 20662 18708 20807 107746 16410 14281 18706 230126 14784 435684 12391 12928 18803 12929 20416 12389 100039026 13712 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events 20779 14184 13649 12361 14360 14170 20970 13043 18976 19164 11604 17202 100042305 64654 13004 59287 19242 208117 100039623 14186 SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta 100040260 19225 102626 271457 73389 16476 17165 22059 12608 18783 12912 17164 15507 13714 14567 17346 17258 13685 16691 13684 17342 56613 226641 73086 26416 17260 19017 18126 11909 20544 13982 19094 13198 22278 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events 20779 14083 19353 16412 216963 19229 330662 12475 67374 14268 17242 12520 17882 270152 21825 19084 21826 19085 22329 140559 22631 19262 18749 13522 21894 12928 11308 16401 11845 19303 12927 18747 20750 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network 22408 73016 84035 14367 192199 26564 70495 13380 16974 14362 22415 14366 22416 16973 22413 22418 14370 68588 22422 14371 22421 14368 24117 14369 57265 16010 20187 93897 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network 18021 16476 12912 328572 14461 17863 17869 21823 14815 18792 20683 17395 23871 21803 16191 11909 17132 12534 13982 11459 12387 16007 19211 12843 12578 230899 21416 17134 67405 26754 14284 382056 22059 14282 13614 22051 23857 13709 12017 11770 11910 17750 13406 16153 83995 21857 12400 18619 11606 15007 12125 14609 12443 15251 13653 12576 20293 16478 18018 18019 14281 12981 16193 19252 16183 15978 14283 16477 16189 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events 16452 16191 20851 19247 18708 18706 14784 17096 12700 16192 12984 20850 53378 18712 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling 73341 16202 16476 19353 12912 17931 20878 29875 64099 21961 12443 12539 76142 56212 140579 18938 170736 57342 11545 26431 67268 56505 22793 56637 78757 17974 20174 75786 21335 68458 67444 225341 21417 11651 15519 20613 109711 12387 103573 54126 13367 19303 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events 19246 26419 19353 11848 14158 14609 12558 227753 18803 19877 19247 640703 12005 18708 14800 16573 16973 13191 12325 18706 12387 231871 14182 12801 16480 14432 13043 13589 269060 18717 12385 17906 12388 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor 218772 19411 19401 20186 22260 17977 19016 21803 21926 20602 20181 20183 20182 22337 12043 22259 20787 11303 19015 19014 67544 21834 21833 19013 15370 P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network 22061 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network 16476 69191 328572 24068 18996 18997 12266 22433 13033 116870 12675 22200 15500 17869 11764 18002 11785 11957 17977 78330 13508 27410 23957 17978 55960 268395 18667 268527 12006 22192 66949 224903 12822 71990 667310 12521 211329 268903 11737 17979 13983 114604 100041004 67488 212391 12034 671392 67040 13982 433759 12189 16911 17128 18538 20185 12608 19109 12443 20602 11614 20850 208727 19014 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling 26419 19353 16412 26413 26417 17390 14159 14360 23871 13449 26416 56458 18806 12575 20851 18479 11651 17973 19247 14786 18815 14061 14784 11601 11602 12928 231130 69257 50915 14173 12169 20416 18127 19303 21687 11607 218397 11600 14083 13709 14268 18033 21926 13712 18708 19697 18706 20850 16402 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells 18021 16186 16476 26419 26413 26417 16185 15461 18750 13656 14939 21936 22163 21942 230398 12010 18761 12525 12526 15976 15975 13813 110157 15007 26395 26396 21926 13653 20849 109880 13712 320139 18754 12500 18176 12502 12503 12501 18646 640703 18751 18018 18019 14281 26420 16184 16183 15978 14103 14283 16653 16477 SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase 16476 26419 19353 16412 26413 19878 11848 26398 16410 330662 14360 23871 22612 73178 140580 16419 18479 17973 20662 22330 14786 11459 14784 21894 30957 12928 232906 12169 54126 19303 109905 218397 20779 14083 71302 213498 245671 110596 13196 20405 24000 12334 110157 26395 12443 18803 215449 109880 26431 17974 109711 18708 107746 26420 18706 20130 16402 12927 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions 16777 16779 16774 16403 16772 226519 16780 16776 16782 192897 16773 FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway 17535 27354 235559 100040608 72775 69928 19367 19718 19356 69263 15574 67196 12190 235610 15270 12649 237911 330554 19355 74335 12234 101831 230484 21975 237211 71885 12144 208836 15205 104806 67561 68275 106344 103583 72151 233826 19891 211651 14088 14087 67030 11920 12189 60534 19360 VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms 17535 21415 72433 14284 26362 73389 56436 110308 22061 22601 64058 21973 15201 12442 12831 55948 12609 12190 14694 18128 56637 11486 16400 15205 22337 18987 20997 16175 16396 50754 14776 12062 16664 226849 13395 11920 107568 56437 16009 17246 12578 67815 14104 211323 20913 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis 22352 21937 228355 12028 11820 11857 101706 670717 20740 12905 14453 57913 26401 20230 11783 12362 227753 12366 16668 12363 66593 12632 12369 20874 21418 16907 11798 13368 13347 16905 16906 21969 12043 11459 12368 14939 16885 14083 11796 21926 11545 12371 18646 12122 12367 12370 19766 11797 20787 71609 22030 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity 73341 57257 109904 53972 219140 19353 319899 330662 192662 140580 223435 545156 216445 109934 16800 277360 24001 94176 110279 229877 23853 20662 13860 22324 21844 70497 11308 26934 54126 19417 19765 19418 52666 22325 228359 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling 16414 11848 15235 17390 18792 17395 15162 67374 18033 17882 21926 215449 20344 21838 19877 15894 11596 18815 238055 20345 19882 16193 21894 14219 83964 434174 18791 16409 18793 16971 109905 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway 18102 18720 18805 545156 18806 19353 26413 26417 11848 21844 18793 53869 11840 215445 11845 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells 16476 26419 18783 26413 26417 26398 16331 12675 26401 14360 224105 17096 18806 12402 11651 19247 20662 15461 22324 13448 14784 14389 20416 19012 19303 19249 50928 215280 56743 218397 14127 14126 14125 14083 16822 15163 18778 14130 208650 16428 110157 16797 14158 26395 26396 18033 18803 20698 13609 12229 18751 18708 16150 19697 18019 14281 18706 26400 16151 19252 20963 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway 20779 22339 14677 19353 26413 18596 14254 12767 26417 14687 11848 14673 14681 14678 14679 14675 14672 14674 14682 13610 14676 16452 23797 11651 18591 A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling 16421 14083 16412 16401 17123 11848 19303 22329 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling 19353 26413 26417 11848 330662 140580 19247 20662 15461 14784 12928 14389 14388 107971 20416 327826 18049 109905 17207 218397 18205 78405 18759 100040603 94275 330914 18211 83814 18212 18053 18213 216148 17179 12064 23873 26395 20418 11350 19762 12443 19769 18803 67903 13429 56212 98878 215449 83945 20848 56470 18412 18176 18708 107746 18706 18762 21844 12929 19417 16653 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events 20779 19353 16428 20393 11848 16331 16797 14360 17096 22612 15162 12143 18803 56484 30955 19157 104709 19159 14191 19158 106952 18607 17060 234779 22637 16332 11844 18176 12229 83436 101476 231821 15519 26377 18708 15461 16818 74769 18706 19211 11840 11845 109905 16653 20963 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events 20185 22601 26413 19116 26417 19109 14360 68652 16452 20851 13874 18183 18708 80707 15200 74769 14812 11491 18706 13869 14784 13866 16396 12223 13385 12398 20850 83961 17999 100042150 16206 107568 20416 17246 211323 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events 26413 26417 16331 110157 17096 12700 26395 12984 26396 20846 20848 22631 18712 18749 16452 20851 20293 18176 19247 20662 18708 15461 16150 14281 18706 12981 14784 14389 20850 12982 20416 15900 18413 16653 20963 18747 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta 29857 16765 12443 320795 20648 65964 26415 26399 26397 13631 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction 19294 69697 210126 17309 13636 211446 17920 13645 11828 13836 11830 216963 233765 65970 17356 20909 22323 13649 16582 11848 15234 17295 22793 19877 17973 109711 76884 22330 12387 20336 12550 50884 16001 11308 16000 18717 12385 13367 11845 17906 12388 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 16416 17164 26413 26417 19229 15170 11848 15239 19271 16410 15516 14159 22370 27371 14360 224105 11640 226101 19255 207565 12562 26416 12389 12402 11651 17973 15519 19247 103583 22330 14783 12387 14784 18750 14388 11840 18127 12385 19303 13430 26397 20779 22339 14083 14254 16542 110157 29875 18753 26395 26396 18803 109880 18607 17974 19877 640703 18751 18708 26399 18706 230126 19094 17999 18747 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation 15361 328572 12028 12567 116870 13684 17869 17395 69719 20425 67154 12530 13681 11757 109115 216185 20713 108143 18712 66464 15510 14732 100088 100043349 208643 72504 12914 12151 56426 15519 21429 67025 59026 380669 12444 16828 13557 21752 67014 72195 64602 66942 22042 75597 18642 13806 15902 13665 67065 68632 17187 12035 18103 14534 18263 56456 18102 15525 17127 170676 17128 100683 27354 21877 22059 20525 56505 20174 20613 81601 11799 14283 18148 REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta 20779 18481 22034 19353 26404 216527 64143 19091 70686 26406 26398 14360 224105 17096 22612 15162 12143 26416 14191 18218 63953 18479 16818 26399 19252 19766 66513 19094 56044 26397 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) 12703 26419 26417 15170 17342 17096 56484 12914 12402 17311 11651 19247 20662 15461 22324 12043 14783 13448 14784 19211 14388 20416 16590 26411 21682 20583 110157 16923 240752 14158 17444 114715 17179 114716 56792 26395 23921 26396 13857 12015 19277 20846 13856 20848 16452 18607 56637 18708 18706 20850 12929 GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network 20423 26419 19206 12159 18550 14178 14734 26420 ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events 20779 22339 19353 16412 14268 11490 22341 22329 11489 20229 16516 74145 21923 21817 11495 11501 212503 18126 14205 12981 104099 12982 19303 12927 20750 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining 227525 319583 59047 21673 54125 72103 75570 66408 56626 108138 22596 14375 19090 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) 271457 16476 26419 19353 26413 26417 11848 26398 16331 13685 15239 19271 13684 26401 224105 23871 56717 19255 73178 18479 12402 20404 11651 17973 19247 14064 20662 15461 56513 12387 14784 12928 14389 12550 14388 20416 12385 11845 19303 109905 20779 14083 19246 11789 18759 110157 15234 17295 26395 26396 12015 18803 13653 215449 18607 17974 56716 16332 11652 20613 18708 107746 18706 18762 18222 97998 16211 70584 224116 58194 226970 74030 12929 74370 13858 67605 74334 12927 56705 EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway 20779 14083 14677 19246 13645 26413 26417 15170 13649 14679 227753 73178 20846 18803 20848 17974 18176 18479 17973 19247 20662 18708 15461 74769 18706 14784 21894 14388 18717 20416 16653 218397 PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events 14702 14062 320129 14677 18797 67804 16801 56440 14688 18795 19878 75547 22323 109689 14687 11848 14673 14681 14678 18796 18753 14679 192662 14675 13429 14672 14674 14682 14676 22793 19877 320795 14064 18751 18708 18706 14061 18750 18127 17906 18752 13430 22068 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events 14083 19353 16412 12767 14177 11848 21788 20971 20315 66911 18753 20304 17395 14268 17242 16774 57916 67903 21825 16772 11489 53378 21923 109711 18815 14061 14182 18750 14173 14369 16402 13430 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway 26419 18519 328572 27374 12566 18002 216080 65019 23988 53892 225055 67956 13163 100043295 26416 26374 17248 219022 13560 110750 67773 226830 50883 69181 73251 333654 19052 12450 110854 12914 11651 67025 59026 11920 12578 15258 22059 93687 27401 214897 21849 252870 18753 70425 103236 27373 11350 104318 12649 56637 22632 26420 12428 68098 81601 17246 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes 19225 18021 19246 16476 208650 14462 12567 19016 16364 21926 13653 13654 16191 57765 17254 19272 12477 13655 66889 12367 22778 640703 13139 17132 20371 18018 18019 14281 12981 16396 16184 16183 15978 13555 14103 21947 13656 381319 18986 14283 16477 16189 18761 E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events 12387 16480 12550 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway 14676 16367 14677 16476 26419 19353 18479 26413 26417 14687 11848 14673 14681 14678 14281 14679 12562 14675 26416 14739 14672 14674 14682 13712 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling 14702 20779 14083 14677 18797 19353 12912 14688 26413 18795 26417 14687 110157 14681 14678 18796 14679 26395 26396 18803 234779 11835 11651 18708 15461 14714 75273 14281 18706 20415 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events 22059 12795 12532 12447 50883 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 18021 14284 16476 328572 23857 83995 17390 18792 14609 20683 17395 12443 16774 20293 16478 18018 18019 12428 17313 15368 16193 13179 353170 16878 21824 22282 18793 11911 12843 18127 14283 12578 16477 192897 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway 17535 27354 13016 21849 54401 19367 225182 19356 11350 26374 12530 15270 12532 50883 21975 12144 227525 12122 108138 81601 211651 13006 11920 20184 70681 12189 17246 24061 93765 27223 240087 19360 21750 HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha 22029 21937 53859 11796 67384 26419 12675 670717 12905 11783 12366 18033 18035 13163 21926 12369 14082 12371 14102 12503 12122 12367 26408 19697 12043 26400 12370 19766 14103 12368 12633 71609 22030 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling 20387 117149 20201 13003 17087 106759 12111 16179 108960 21899 21898 11848 142980 20210 12675 20202 24088 21897 266632 17874 12475 15510 16150 16151 434174 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events 16451 14462 16173 16171 50931 20847 16162 16159 21803 20846 246779 21926 50498 20849 20848 16452 16176 57765 54721 16161 16160 16193 16183 15978 20850 16195 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling 26419 19353 11820 11848 12675 670717 11783 192662 66593 11798 18749 11651 18815 13555 12368 20416 18049 11796 22059 22034 18205 78405 16179 18759 94275 17393 18211 18053 12125 17874 12064 12015 18550 17984 17136 68585 18412 20661 72843 22627 192656 12070 75625 18377 170936 19716 20598 66647 12371 11852 11853 235402 17392 12367 18708 16150 26420 11491 18706 18762 16151 11797 26414 19164 100042305 59287 208117 100039623 CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway 56637 14367 606496 214897 11789 16974 72293 12005 13542 18719 240756 22416 13544 13543 71810 26554 12387 84095 226849 12389 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway 20779 16476 26413 12393 26417 24064 19229 15529 18792 17395 14170 12558 20846 18803 64654 12322 14186 18607 14184 20851 12402 11651 19247 20662 18708 14281 18706 20111 14784 14182 231637 14164 70584 83379 12550 13043 171463 17967 18793 14183 14388 20416 327826 12388 20750 ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events 17128 21909 17129 11705 55994 11477 110542 12162 14225 12168 17125 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity 84704 114774 215114 18813 57257 225115 15382 50523 57908 75502 56406 104263 19229 627557 12445 14228 22200 22215 18095 21413 232286 18477 56218 227753 328365 17152 72993 17978 21815 268903 11835 11651 12571 20807 75273 12387 22596 14375 12189 59004 12578 19090 229615 12443 59035 99982 50528 12370 56469 22196 19014 227292 110651 56705 14200 21804 76804 E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes 18720 22793 20779 19353 11651 11652 13649 22323 11848 18708 18706 12387 14360 16480 12550 16475 12374 18803 12385 12388 IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events 16476 16451 12608 19353 12048 26398 21857 17869 17342 18753 229615 12609 15162 20846 16803 26416 17210 22027 20848 99571 56458 19267 21943 12702 232345 12944 16452 16362 11651 54721 19247 20662 18708 22324 14281 26399 18706 14784 16193 14389 19094 56469 14388 16477 16911 16195 16194 EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway 13837 13836 13842 13840 13841 13839 13640 13838 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway 27354 235559 18817 19361 12566 54401 269582 19367 19718 19356 69263 15574 12530 12190 235610 12649 12532 22631 19355 12234 17220 72930 214552 19052 17216 51792 23834 66131 54380 21853 68275 106344 103583 72151 19891 12428 211651 17246 DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin 12234 56637 93687 14367 606496 11789 26965 16974 21402 12005 13542 22416 13544 13543 12387 27373 104318 12006 IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway 16367 14083 19246 110157 18753 12015 14694 22627 22631 18607 17974 11651 18760 19247 20662 18708 15461 14783 18706 14784 18762 12928 16001 16000 384783 20416 12929 19303 12927 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin 16176 26413 26417 640703 71914 26398 195046 69538 26399 26400 16173 12362 26395 26396 21926 18667 22329 26397 VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods 19682 245650 243923 77974 14688 14697 107477 14913 212541 24013 20215 19892 225600 19739 18587 79235 14699 214111 14685 14919 12788 18588 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network 193740 18021 14451 27401 328572 18817 12442 12567 12566 17869 17390 20683 26395 12443 12190 12531 50883 606496 19645 12914 104156 12534 14281 12428 13982 11799 18005 54124 108000 12615 14235 12616 12578 22594 16775 20877 12447 21802 15379 IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events 14702 110355 227288 271457 18797 14688 18795 109689 14678 18796 17096 15162 14675 13429 30955 104709 14191 14676 18805 18607 18754 12402 216869 11651 18751 18750 18752 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions 16456 21810 78369 16411 15896 14131 100689 110135 16414 14161 14723 12266 14058 19123 18792 385643 99571 22329 21838 15894 381924 83964 16007 16408 18791 16409 18793 21947 INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport 20528 19047 20909 16334 18759 106628 240028 50518 55948 22318 54401 104215 14936 16337 140491 100039786 22628 22627 22631 22629 210789 56637 11651 11652 640703 18762 20913 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway 271457 16476 18783 17869 14360 22612 23988 73178 30955 104709 20851 12402 13860 16818 232906 16971 18591 13430 18596 17356 94212 110157 29875 26395 26396 11350 20846 215449 20848 20698 13609 16452 17974 18708 76884 107746 74769 18706 26400 242687 20850 13043 50884 26414 11308 110651 12927 19106 16706 26419 19353 16416 26413 26417 68089 67771 11848 26398 11867 56378 19271 16410 66713 74117 17096 19255 192662 15162 108100 12143 101314 76709 14191 72930 19052 51792 18479 17973 19247 20662 15461 20807 14783 13448 14784 12928 18750 19211 14388 20416 109905 218397 20779 19246 12988 55948 54401 18753 20491 65962 21345 20469 26941 18803 69710 98910 19341 214384 100039786 238130 22628 60595 22627 109880 22631 13712 22629 18754 18176 16478 14281 26420 16653 22325 ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway 11477 14225 11482 NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway 19294 20779 16456 14083 227377 19353 16416 18596 17356 29875 16410 215449 12737 58998 58235 19274 18708 107746 18706 12387 21894 12928 12550 18717 12385 109905 18591 22325 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway 16476 26419 19353 26413 26417 15170 16331 12675 26401 23871 17096 26416 100039026 11651 20662 15461 13448 14784 19211 26409 20416 218397 12988 22034 14130 94212 26411 110157 19055 26395 18033 18035 13712 18607 17060 234779 24056 12047 19057 240354 12229 108837 108723 19264 26377 18036 12517 640703 12518 18708 16150 12478 19697 18018 15985 12483 14281 12325 18987 19056 18706 12042 16151 22325 20963 REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity 102098 207212 57257 109904 53972 16801 213498 110596 75547 11857 11848 11855 192662 69710 223435 13605 12576 106952 216445 109934 16800 110279 23853 22324 17925 72754 69632 171207 232906 11856 213522 14570 442801 117600 71704 94190 50768 52666 234094 22325 56349 73167 17207 223254 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin 22249 20910 20614 20979 20907 11435 22318 NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway 328572 18129 18131 14462 18132 13388 13728 50530 56309 17869 16449 225164 11487 14357 17150 13389 18011 227325 16450 13386 12805 16924 54485 53870 12234 12575 12402 26965 21402 433759 13806 53869 20185 27401 19208 13016 225182 12443 18550 13429 103806 20602 56381 11489 18128 22632 99982 19664 270118 18222 16396 50754 100042305 13858 59287 208117 16189 100039623 GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network 17242 71951 IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 16186 16451 16453 12048 13709 16992 12445 17869 20683 20851 18646 19247 16185 12571 20662 18708 20371 12043 12444 16818 12428 18706 14784 16184 16183 14389 20850 14103 20416 16189 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events 20779 16476 26419 19353 26413 11435 26417 110157 56717 26395 26396 12015 20848 84092 18016 67588 16452 13867 11448 73181 67299 18176 11651 19247 20662 18708 15461 74769 14281 19056 26420 18706 14784 13866 26414 100042150 20416 16653 211323 18747 IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events 14702 271457 18797 14688 18795 22323 109689 14678 18796 17096 15162 14675 140580 13429 30955 104709 14191 14676 18607 18806 19052 51792 19354 12402 12765 216869 19349 94176 11651 18751 18750 53869 18752 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks 15376 15375 15377 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events 20969 20970 15529 20971 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions 22339 16456 21810 20969 16416 110135 18596 14161 94216 226519 12830 16542 20971 16410 22370 16777 18792 21813 12829 14268 12828 12826 21825 99571 12842 20698 21838 21923 15891 14118 16728 18613 13612 16423 16007 434174 18793 16399 12843 18591 16775 20750 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway 14061 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events 12703 16186 16476 16451 26419 16453 17164 26413 26417 19229 11848 12566 17869 14360 13449 26416 20851 19247 16185 20662 15461 12043 16818 56324 14784 22780 20844 14389 216233 384783 20416 218397 16367 110157 12700 26395 26396 20846 20848 12702 18754 18176 18751 18708 14281 26420 18706 16184 16183 15978 19094 20850 16653 20963 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway 14733 14734 71951 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway 21853 20893 27373 53610 11865 12953 12952 12753 140858 18626 12649 18627 217166 18143 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events 12703 16186 56717 26416 19349 11909 20852 16185 16818 14939 12010 26397 20303 12525 14938 12526 16177 17873 18034 13813 15284 23882 12774 19698 15007 16173 18033 16162 16159 20846 20849 20848 192656 16452 16182 14969 14968 16176 57765 12500 12502 18126 16174 12503 12501 54721 19697 16161 16160 14281 26399 16184 12504 16183 15978 20850 14103 56632 16189 BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions 16420 16421 20969 21812 17123 14118 16410 13612 22370 18792 16007 14268 18793 320910 16401 16419 22329 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis 16202 57257 19353 16416 26413 26417 19229 11848 16410 22370 21813 12402 11651 15519 19247 22330 13612 21894 16001 14173 16000 12843 19303 16367 12977 20779 22339 16456 14083 12978 20969 12833 12832 12815 30924 12814 18704 12831 78560 94216 17304 12830 16542 224020 107650 12829 14268 12828 12826 12825 12824 12842 12576 12836 12835 19877 12834 18708 18706 12370 12927 20750 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III 22059 18519 328572 12028 22151 60525 64384 22143 17261 50709 93759 15395 68738 64383 56484 56458 209011 12575 19017 12914 17927 208727 14375 14200 54601 RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling 218772 19411 19401 26419 18519 328572 26413 26417 17977 19659 17978 17420 26416 12572 66671 20602 15183 268903 20181 20183 17979 12914 20182 11651 22337 12534 433759 18750 18752 18747 HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha 26754 11863 22059 15519 67923 112407 112406 22346 15251 71745 12578 53417 319594 56292 14694 216440 56438 FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network 20387 20423 16476 12608 328572 16334 22433 18095 11764 22370 11957 20683 78330 13508 20703 12576 12822 11819 320951 667310 14526 20390 22287 268903 18029 11835 72082 17979 12914 18027 15376 114604 15375 100041004 15377 14281 238055 13982 18986 12189 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway 26419 93687 19353 11848 18099 22612 19016 12322 68652 19877 14367 26564 216869 208846 192176 84505 13542 320790 13544 18019 13543 26420 22418 18762 68588 66513 26414 14368 26409 14369 57265 PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling 14702 20779 14677 18797 14688 18795 19878 14687 11848 14681 14678 17390 18796 14679 17395 14675 14672 14674 14682 14676 18176 13983 11651 20662 18708 15461 268980 14680 15200 75273 18706 13982 14784 19094 16001 16000 20416 18127 17698 16653 12927 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription 21415 67772 16543 14175 16476 73389 67087 99377 72693 81004 328572 18014 64406 73739 80334 12592 59024 12291 17869 17390 17342 21413 17395 17978 12006 12234 11835 13380 26965 21402 12444 21752 12387 15182 433759 16007 12550 15902 12578 16842 21416 100683 13003 11789 13016 20583 55948 54401 12443 12326 100039786 22628 22627 22631 22629 20174 21885 13544 17709 21414 20997 140486 21886 20586 234130 21372 11513 103573 665113 16600 21888 17877 14797 16678 17928 77578 18741 16319 12590 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway 26419 12048 15170 21682 16331 16923 17096 18033 13857 20846 18803 26416 13856 12702 16452 234779 20851 12402 12229 19247 20662 18708 15461 12043 107746 14784 20850 14388 384783 20416 12929 109905 22325 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway 17873 22034 19353 23882 216527 26406 269881 53608 26401 22166 330177 216965 26407 26416 68652 26408 640703 12323 26399 66513 19094 13197 11920 26409 22030 26397 C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway 100683 73389 27401 22642 17869 224105 23988 18854 109115 216185 108143 66464 56505 56637 20174 19052 12005 81601 72195 50754 226849 12578 17187 14534 56456 S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway 19225 22339 14677 19353 26413 18596 26417 14687 11848 16542 14681 14678 18796 14679 17250 18803 18591 20698 13609 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network 17126 20779 22339 14254 11820 14360 17096 22612 20563 21813 15162 11905 19122 12143 620395 21803 16772 14191 21809 21812 16818 14182 14733 14173 211323 ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins 16476 18797 26419 19353 18783 26413 18795 26417 19229 11848 18796 18755 26416 70086 224129 11512 11514 11515 13617 13616 13615 104110 13618 58861 432530 210044 105243 104111 11651 15461 20544 12928 18750 12843 18761 20779 14677 13614 14687 14673 83995 110157 14681 14678 18753 14679 26395 26396 14675 12825 14672 14682 14676 16452 18754 18751 14680 14281 11513 12927 18752 22068 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network 22339 14205 18654 18187 14254 18186 14257 22340 22341 16542 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte 16476 26419 19353 18759 26398 14360 73178 12015 18803 17974 216869 11651 17973 14064 21872 18708 12488 170643 74769 54631 26420 56513 170484 18706 14784 18762 26414 22068 LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events 14702 16476 18797 19353 16801 14688 19229 11848 17390 17395 17096 224129 11512 14674 11514 11515 104110 18806 432530 210044 104111 11651 18760 15461 65086 14745 78134 53978 12928 11548 14388 19303 20779 14083 14677 22051 13649 14687 14673 14681 14678 18753 14679 65962 18033 14675 18035 18803 14672 14682 14676 56637 18754 12367 18708 19697 15200 74769 14281 21844 11513 12927 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions 16398 241226 213119 16412 226519 16410 22370 18792 12475 67374 17242 12520 21825 21826 99571 22329 140559 12822 14118 114249 121021 18793 18073 12843 16775 22339 21810 12833 12832 110135 14161 12815 12814 12831 94216 12830 16780 16782 16773 16777 16779 12829 14268 12828 12826 16774 12825 12824 16772 12842 16776 74145 12836 21923 12835 21817 12834 16400 104099 16401 16403 16402 16404 319480 20750 109700 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling 14289 20779 14293 76701 19353 16416 16412 110135 18596 16414 14161 50701 13649 16410 22370 15234 330662 18792 17395 14268 21803 99571 16419 16400 17392 18815 12928 16409 18793 16971 56640 14756 13035 16402 22359 17381 12927 17386 71785 18787 14294 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression 12912 16412 328572 17869 20683 19650 56484 20375 12579 12575 15183 110854 13380 12043 22418 433759 15902 12843 12189 17187 17126 17127 17128 14581 21374 94280 15360 12192 22642 18596 18044 18045 18046 12759 13435 22084 18173 66271 14319 23894 20304 12609 29811 12606 17988 229663 21873 20377 12443 56752 17122 56363 12576 21673 16852 13866 13198 13197 12633 16403 15900 192897 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network 13867 13645 15519 13874 13649 18183 15200 13869 13866 12223 83961 100042150 11839 211323 21802 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II 14702 110355 14688 14461 56233 15185 15184 22151 54401 14815 22143 12053 232232 12326 17260 20602 68558 170787 19727 71458 22627 79221 15183 15519 20807 14460 13982 103573 208727 22196 19384 19386 TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling 229317 22601 17131 75788 18854 21813 13163 21803 12389 11798 19045 68652 19052 216869 21809 21812 20662 56513 12387 14784 14219 66513 26409 20416 17126 17127 17128 83814 12322 22627 66313 21814 17872 18607 73122 240025 20742 68010 71978 218441 67068 93836 19053 20901 12005 230597 13132 16396 107568 14225 ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions 16421 16407 12550 JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway 16822 16476 26419 18751 26398 26411 16797 13169 26401 17444 12928 26409 12929 26410 ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes 18021 54720 26419 12048 328572 12028 26417 26401 18755 26416 100039026 18712 12914 12043 18750 18761 93687 55948 54401 18753 17261 12015 12326 100039786 22628 26410 22627 22631 22629 56637 18754 12367 640703 18751 56398 18018 18019 100039592 26420 227720 104248 14232 18762 16211 53901 103573 19384 238276 14225 18752 18747 15370 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells 53859 15170 16331 12675 14360 12402 11651 17973 19247 20662 15461 22324 16818 14784 14389 18750 19211 20416 109905 18761 64177 16822 12988 22034 16428 94212 26411 16797 17444 18803 26410 18607 14969 14968 22637 18754 12500 240354 18176 12502 108723 12503 19264 12501 192176 18751 12487 16150 19395 12519 13169 12524 12042 54354 16151 22376 12504 109305 24055 53416 20866 23880 19419 77799 16653 VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals 22339 26413 14254 26417 216148 18803 15251 12389 18607 12402 18654 18187 11651 17973 15519 18186 19247 640703 18751 22340 18708 12488 18706 18750 18127 18747 218397 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events 14784 56717 13645 13614 20416 13649 20662 15461 13617 HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins 14702 14634 67661 14677 20423 19335 100041953 93687 214897 14633 14688 19206 19646 20466 14687 14681 14678 18753 14679 70425 26395 103236 27373 245688 104318 12234 56637 60406 12914 216869 16854 15376 11651 20467 103583 15182 433759 56469 103573 211401 269209 24069 20747 16568 21821 18747 319757 14632 INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway 16367 105504 19246 211446 20411 16334 20393 18759 106628 16331 13685 104215 16337 23921 56484 12389 19262 18607 17974 12402 11651 17973 11652 19247 14064 53413 20662 18708 15461 107746 14783 56513 18706 13448 14784 18762 20336 12928 69940 50915 107371 20416 66482 218397 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network 18590 54635 18595 18596 18591 71785 EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling 20779 14083 13636 57257 16332 19353 13836 11431 12402 18479 11848 18708 18706 14784 21844 232906 20416 22325 12927 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling 100040260 23980 271457 16476 12048 12912 19060 11843 23938 56419 17907 23939 26405 19730 22695 67603 56613 73086 56717 73178 17260 11909 11651 667739 13860 56044 13645 13649 110157 29875 26395 26396 20846 20848 78757 56716 227743 18708 76884 74769 18706 242687 50884 11308 110651 16706 26419 19353 26413 26417 68089 67771 26398 11867 56378 66713 74117 26401 27371 108100 101314 76709 17125 18805 18806 19052 51792 14064 20662 15461 20807 20544 14784 18750 14388 20779 12334 55948 54401 18753 12015 98910 13653 100039786 22628 22627 109880 22631 13712 22629 18607 71978 18176 640703 14281 26420 225870 18762 19252 16653 22325 LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development 19353 21770 11848 100040603 29875 18472 13424 56430 23924 12570 18476 11350 13131 17755 13193 83431 18475 19699 12569 27226 100039026 22627 640703 18221 12568 16976 22359 SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL 19352 19245 20779 19877 12575 19353 16412 26413 11853 26417 11848 12566 12428 11606 22143 13653 19244 12927 12447 56187 107503 109700 EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling 20779 26419 19353 16416 26398 14360 17096 22612 15162 13844 270190 12143 13429 13642 13641 14191 50780 17974 13846 18708 16818 18706 21844 16399 26409 19249 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium 16398 12912 16412 26413 26417 26398 14268 26416 12842 22341 14205 11651 14257 20662 18708 18706 20111 14784 12928 19094 12843 20416 16401 16402 109700 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events 20779 13636 13645 13836 16416 216963 109689 13649 15234 17295 14675 14672 14682 19159 19158 14676 78618 16554 320495 16867 216869 216859 50753 212285 231821 17973 70676 232227 11555 16399 22095 11845 19303 11607 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network 16451 22061 22601 328572 12028 12795 18817 12566 17869 16190 20683 23988 93759 12366 18854 16450 26416 56484 12235 18749 11486 12575 12571 22062 12237 319618 12534 30948 16180 226646 229933 21945 15499 22431 22142 14252 11576 18196 12018 207742 23886 19012 63958 68048 18611 12448 268882 18787 14651 223752 56612 19361 18211 55948 83814 12125 11350 12190 12649 14694 20703 15214 19645 14102 80707 19697 14460 12428 68098 81601 16396 19094 17246 14104 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events 14702 20779 20292 14677 56066 56744 12766 55985 14688 26413 15945 26417 109689 14687 110157 14681 14678 14679 56717 26395 26396 26416 13429 18607 78757 56716 18176 227743 11651 17329 18708 15461 74769 26399 18706 19094 16653 26397 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events 12608 12048 16188 27058 194231 16331 12700 12984 22628 22631 18712 18749 16452 15901 20851 19247 18708 18706 14784 433759 14389 20850 20416 18413 18747 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling 110355 14702 320129 19353 16801 14688 11848 14360 18796 22612 17096 15162 12143 18755 26416 14674 30955 22329 14191 104709 216869 11651 14697 170735 15894 16818 18750 53869 18127 18761 20779 13645 19091 13649 19222 21390 14673 19214 14678 18753 14675 26941 13429 14672 14682 14676 21817 19877 18754 20339 18751 18762 19094 20963 18752 18747 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling 13645 19353 16412 13649 226519 15235 16780 18858 16782 55948 12821 16773 54401 12527 16777 16779 17295 16774 12369 16772 100039786 22628 16776 22627 22631 22629 13867 20181 20183 20182 11651 18708 15461 18706 16175 14784 19882 13866 12550 18750 20416 16403 16775 192897 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway 26413 26417 13685 12566 670717 13684 56430 56717 18854 13681 12234 18805 18806 11651 103583 15461 18750 12447 16367 20393 22084 110157 55948 54401 12421 64930 75705 26395 13629 26396 22241 54170 18569 109270 73826 52187 29869 100039786 68441 22628 51897 22627 109880 74747 22631 100042570 22629 106298 18607 245670 78757 56716 22632 19017 18176 227743 16150 20111 97998 20787 74370 67605 16653 13631 ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway 12234 53859 18034 18033 19698 12675 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors 16476 12048 13836 64058 328572 57913 11783 20683 12362 12053 26374 110750 12450 12575 12914 13380 15375 22062 22337 12043 21781 15182 13555 16878 12368 11576 12018 23886 14534 18787 13003 13649 11910 74747 26921 20312 19079 21933 242705 19645 71887 15469 14102 107986 12177 12122 27056 29813 14149 66824 57748 21981 68428 13207 20586 14000 71361 235281 268973 14775 13496 382985 15194 67941 17246 12607 209456 218215 22178 20750 17685 66813 59092 17350 60599 12050 22061 319801 140742 12028 12227 12795 18996 12142 18997 18861 15248 20400 13033 66214 94223 69076 17390 12454 21354 18854 17210 12389 108143 12822 13615 12521 13557 19211 21802 193740 18538 100683 22059 18044 11789 18045 18046 20583 22084 55948 15234 17988 17295 20724 59035 12047 68098 19252 240672 12062 13197 16009 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events 104110 18754 432530 210044 104111 12912 14680 78134 73086 11513 224129 11512 11514 11515 18747 POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly 18102 20779 271457 19246 13645 19353 56440 15170 13649 15239 14673 29875 17393 18212 19876 11487 14360 16002 12064 12558 104836 17295 109620 17288 11350 63955 20562 56805 14674 12914 19349 17392 12367 15461 14573 12387 21844 16480 12550 19713 16001 74030 12385 11845 12388 14585 13430 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling 22059 216963 21770 20878 72119 18035 16475 83431 218977 100121 12531 66077 18245 12877 56371 56637 75786 21335 18479 11651 11799 13197 19384 12615 54126 12189 17246 320165 20877 18747 218397 CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling 22029 53859 11796 16476 26419 16453 22034 12048 208650 26398 17869 26401 18033 18035 26416 30955 104709 22031 64435 56196 21939 21929 11651 18708 19697 74769 26420 18706 19094 20850 11797 26414 21947 22030 16189 VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network 71990 236193 20587 17979 13983 12266 57376 22200 18002 20586 17977 23957 17978 22192 11614 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases 20878 20877 LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events 17128 22059 12912 13728 13033 22084 55948 17869 54401 64930 56717 12539 100039786 22628 22627 22631 22629 56637 56716 12283 75770 20869 19165 15519 70661 232944 22350 71728 381979 70415 66993 17691 13982 72149 235344 74343 18612 227154 74370 67605 18747 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway 13846 13845 13844 270190 13642 13641 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway 18205 12912 17164 26413 23938 26417 23939 26405 110157 18753 73086 193034 26395 19762 19769 26416 98878 13653 215449 17260 12569 109880 13712 18176 15461 20807 14281 26399 20111 12568 109905 16653 26397 TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway 22029 21937 11796 67384 228355 18201 26406 18759 12675 26401 22166 18033 20846 21926 12389 18412 14694 68652 26921 21929 14082 20598 26408 20597 16150 19697 11491 26400 18762 12370 16151 19766 66513 11797 26412 665113 27206 74256 26409 399510 225028 67338 71609 21938 22030 26397 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks 11364 22228 22139 11370 18609 12894 12608 15107 12912 71911 234724 230163 18534 16334 20526 20927 16514 21869 14377 16006 15227 14815 12609 21405 20683 12606 11655 103988 11657 78070 13386 15378 15376 11651 15375 18015 15377 14061 22042 11576 11806 100040592 12895 18770 CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events 16476 26419 19353 26413 26417 68089 56419 67771 26398 26403 11867 56378 66713 74117 26401 224105 22612 56717 73178 192662 108100 26416 76709 404710 18805 18479 12402 11909 14064 53413 13860 15461 56513 12387 12631 12550 12385 54126 17906 16885 16886 26397 20779 73341 11789 110157 29875 15208 51789 18000 226751 18508 109880 56637 18754 18708 26420 26399 13383 18706 26400 18762 21844 70584 19417 22325 12927 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events 110355 14702 18797 19353 14688 18795 19229 15170 11848 16331 15239 20315 14360 18796 17395 22612 17096 56717 15162 12143 56458 14674 30955 14191 104709 20851 18479 216869 11651 19247 170735 22324 16818 12928 12631 19303 16885 20779 14083 14677 12988 64143 12767 94212 14687 14681 14678 14679 20847 12015 20846 13429 215449 20848 26385 20479 14694 50778 116733 56085 16452 18607 14969 78757 14968 56716 12500 12502 11852 11853 12503 227743 19264 12501 18708 74769 18706 18762 16396 231637 12504 20850 12927 P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases 16985 102626 14009 17164 12912 15507 20807 110157 22084 55948 21823 54401 19094 21423 26416 12531 100039786 22628 22627 22631 22629 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling 16476 93687 26413 21770 11789 26417 13016 13388 18099 17869 11487 21405 14357 22408 12443 100039026 12234 18128 56637 73016 56811 93960 14296 21885 12914 13380 16974 14362 13542 12005 103583 19664 14281 12387 433759 66513 19164 17999 24117 26409 100042305 19015 14797 59287 208117 100039623 VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms 20423 73389 22061 64058 328572 12028 18817 17304 12675 16449 18753 20683 18854 11350 63955 100039786 13654 12234 20724 11486 12575 16400 192119 22032 14102 20833 18294 21420 73472 20148 16150 14149 14027 22337 18104 66993 229933 16396 14776 14252 13197 107568 23886 17246 16009 12578 68048 192897 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway 12703 16451 15979 12608 328572 26413 17131 26417 26403 69635 26401 18753 12362 19255 56717 26395 108058 20846 215449 12322 20848 16452 16176 12402 12914 16362 11651 19247 640703 18708 107746 12323 96979 12325 16391 18706 15978 56469 12929 59004 109905 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway 18720 18806 19353 12847 13196 12757 56041 107338 228998 12504 76932 11771 11773 56494 68137 74325 11840 260302 19158 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events 73914 16177 16476 26419 22034 16179 26406 18759 12675 266632 12362 17874 18033 18412 68652 16176 18708 16150 19697 16180 26399 18706 16175 18762 16151 66513 26409 16181 54473 93765 111173 16178 66589 225471 GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network 22088 74551 18514 16476 12640 26419 110308 14229 68094 12912 19060 83797 328572 26413 12028 12355 22354 26417 225888 14462 100043429 18736 14228 16667 14815 17977 17978 26416 20375 99571 12569 18749 16191 12575 20851 12914 11651 15519 15894 15182 433759 11576 12991 21374 22059 20393 83995 19109 55948 18033 20846 13653 20588 22629 56637 57765 16362 20339 16163 19697 18018 14281 26420 12981 16193 20586 16183 15978 19094 20850 18976 26414 16664 12568 18986 17246 16189 18747 15370 INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 22088 20779 271457 14083 13645 208650 24064 13649 15239 110157 100041766 218038 13854 216080 70527 231125 66700 104015 13429 84092 16443 18176 12402 20404 20662 18708 15461 74769 18706 14784 66105 58194 16206 20416 54126 13858 16653 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network 73389 18519 328572 27374 15248 12445 12566 17869 18792 11783 20683 93759 17215 18968 104158 19650 234677 20859 12369 12530 17865 17210 22294 83767 20135 20133 22171 12580 13909 19385 56353 67935 52679 50496 12575 23834 436059 13361 12914 67155 211586 18392 22062 12534 21781 13557 433759 13559 13555 104394 11920 12189 12578 22594 12447 12448 14534 18787 100683 21877 235559 209446 19646 19651 21849 12606 225182 12576 22632 242705 19645 12428 12419 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway 21937 12234 21929 240354 22034 257632 16150 19697 12675 12042 66105 16151 18033 18750 11797 18035 103573 74256 21926 11920 19384 111173 192656 EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling 14360 13839 13640 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells 53859 15170 12675 14360 12402 11651 20662 15461 22324 16818 14784 18750 20416 109905 12010 18761 12525 64177 12526 16822 12988 22034 94212 16797 17444 15007 18803 26410 18607 22637 18754 12500 240354 18176 12502 108723 12503 19264 12501 18646 18751 12487 16150 19395 12519 12524 12042 54354 16151 109305 20866 19419 16653 REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase 16476 20687 26413 20466 26417 22215 17869 20683 56717 245688 21803 229512 60406 17119 11651 15519 22427 208084 20467 28113 245474 101185 21749 497652 13982 21752 103677 21951 15182 22596 22431 15381 433759 98999 13555 11546 57321 72400 100043508 11920 14375 17187 19360 21750 17535 17127 15976 100041953 27354 13645 19646 13649 19367 18033 11350 12443 15574 22627 12576 19355 11819 12144 16362 14281 16183 15978 REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein 16476 328572 12567 12445 12566 17342 93759 19016 26416 17260 20375 14836 19052 20587 12575 15183 12914 11909 17927 12418 21429 12571 12444 21781 13557 433759 13555 104394 270627 18505 14312 12578 19660 20937 12447 13433 12715 56321 223922 21374 12608 27401 19646 13709 12393 13016 110157 12609 12606 17295 11350 12443 12576 21808 20390 242705 19645 26420 12428 12981 20586 19094 17246 REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling 17126 73122 17127 218210 17128 19042 69274 26413 26417 640703 100039592 227720 26401 16211 22196 227292 59004 HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network 16476 12912 328572 16414 14461 56233 20315 20683 23871 17977 17978 17210 15378 21786 13805 12914 11651 16828 21752 15368 22042 13806 15902 18787 26754 17127 22339 17128 15277 13614 15275 79362 11520 12767 14151 230099 18671 16846 18655 19883 112407 11535 12870 20525 16006 23959 26357 72157 18746 18641 103988 17988 11674 170768 20893 17684 22041 18550 13856 15251 100042570 11863 18126 14281 18148 REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway 26419 16412 26403 18472 14360 14811 13131 19099 17755 19699 12569 56637 17974 16800 16400 12402 11651 18708 107746 14812 18706 26400 12568 16976 12929 22359 109905 TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway 21933 14082 26419 26413 26417 26398 18708 20597 16150 12675 74769 18706 26401 12370 16151 19766 65111 12633 22035 71609 22030 RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling 14702 19094 26419 14688 26416 12918 14680 26420 SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP 12977 20779 22339 19246 16451 12978 16453 13645 229317 16412 18596 13649 16334 16542 15234 16337 19255 17295 20846 70361 19341 20848 20851 12914 20852 20662 18708 74769 100039592 18706 14784 16211 20850 56469 14388 20416 18591 19106 109700 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling 17128 19042 69274 26413 17131 75788 17129 12159 55994 66042 17130 11798 18121 12168 66313 11625 12156 17125 68652 17872 69585 19045 12161 56637 12166 12667 68010 68799 12622 218441 244058 23892 14313 20481 227720 66513 26409 12162 227292 PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events 14676 14702 19877 14688 19878 14065 14064 11848 14061 18796 14675 14672 14674 17906 14682 FSH%NETPATH%FSH FSH 26396 12640 11652 14308 14309 72993 14772 26385 HEDGEHOG%NETPATH%HEDGEHOG Hedgehog 22627 19207 117606 70208 59024 69792 264064 100041953 12387 110355 13548 14451 269209 14632 14633 16147 216869 13363 24069 19014 75050 18747 19206 15245 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor 433759 15507 11651 14083 11835 18708 12912 TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor 19085 13163 19087 75901 75788 76630 19303 72183 12443 15529 18744 57258 17222 20481 56440 54601 67804 20682 20692 16478 20742 12189 21417 21781 211586 17977 21803 21808 21809 21813 21814 216080 100041766 66105 22196 22337 103573 76793 17869 227720 75465 67068 12399 54709 52563 69150 69957 12234 12442 230597 12505 24136 12530 22062 218210 13982 216869 433759 11651 14083 11835 18708 26411 12393 56484 14281 14282 16476 16477 20683 18607 20869 19645 22059 11909 12928 21402 12927 26965 12389 66513 18519 56438 26397 26399 56637 218441 23871 11910 19651 18706 13132 71770 68015 12567 12571 12575 12447 68999 22601 13018 26754 71728 12385 12386 17691 56458 268288 386655 104394 13805 18709 14030 14225 269338 14272 17872 97064 272359 99152 52206 15378 15405 15481 69260 16211 17128 17130 17258 17260 26413 12705 26417 18044 18045 18046 18102 56513 56371 59008 56317 94093 228026 18854 19042 71978 TCR%NETPATH%TCR TCR 107321 12519 12524 26558 73341 26431 12534 140580 14389 22388 27277 26396 12387 13548 11651 14083 18708 12912 11909 12928 56637 18709 26413 26417 19303 11486 16923 27387 19419 19395 56324 57257 98221 12608 20218 12469 71520 100039786 12675 30925 329693 83490 67300 26410 12914 12929 26416 12477 74039 13139 13205 13367 13430 94176 13448 12934 72349 269378 13653 13807 22154 13837 107508 19229 14158 286940 20430 320150 104248 12488 11350 23880 14381 101540 19260 14569 16797 54390 52013 53416 14784 107746 13169 232906 54167 12306 11744 432467 15516 81489 16150 16331 16428 16438 16453 12521 16818 16822 16828 16832 11857 240028 17085 17096 17829 17973 104112 18003 11928 18018 18019 232975 18033 18035 18036 18295 18479 20403 23853 77647 14026 56233 18613 227707 11431 18648 72157 240752 224020 18746 18803 234779 234374 233315 240754 74195 77853 170643 19056 18753 94212 56444 18760 59079 23939 26419 19094 26395 93742 140721 70737 15170 19247 19248 19262 19264 545902 11459 110157 19384 109905 218397 19697 71911 53378 24055 230126 20416 20491 20637 20662 20663 20779 20846 58231 20963 21682 22042 22088 22145 22165 50493 22323 22324 22325 22376 215280 22631 22637 108705 217069 22142 640703 72482 108723 72828 227937 78473 12402 208650 11502 192656 12523 54126 19134 12042 54353 68481 171543 13449 27371 19200 22248 12481 15239 13549 12500 12501 12502 16800 12504 12507 12516 12487 17444 LEPTIN%NETPATH%LEPTIN Leptin 20218 56637 12675 20416 105787 20779 20846 108079 18754 20112 20528 13649 18035 16370 13685 14360 606496 13684 667739 16367 16451 13866 17977 12568 12632 12944 20399 14682 192157 100705 18803 16001 234779 16419 16846 16885 18127 54611 11651 14083 12393 14784 26413 26419 13982 16150 16453 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor 13685 14360 667739 12566 11651 12984 14159 18708 15461 18750 15162 328572 16452 18751 26419 12703 16476 14786 20111 14191 58194 16590 16197 19247 22612 11909 56717 12928 17342 19273 67296 114715 110157 114716 13857 14936 218397 56150 19697 17179 17311 71520 56637 17698 19684 20850 29857 20851 18706 22350 67300 20662 21933 54607 20779 56468 12929 20846 26416 21682 22376 215280 11350 208650 26413 16331 16453 BCR%NETPATH%BCR BCR 13685 14360 606496 667739 12566 15162 18751 20111 12675 12572 12929 23921 26416 240354 208154 13712 14130 18717 240168 56792 19253 13448 14886 17060 15163 15387 16439 18021 77590 30955 18718 670717 242248 18761 12028 101476 83436 12053 20303 20848 12229 56743 117150 21432 18720 18719 108083 12369 14784 77799 107746 12371 17164 12483 12517 12518 15985 16150 16428 16438 16818 17096 17973 18003 18019 12387 18803 11651 14083 18753 12912 26411 18760 56484 14281 14282 16476 16477 18607 19645 15170 11909 12928 12927 218397 19697 56637 24055 20416 20662 20663 20846 21682 22324 22637 18709 108723 12042 26413 TNFALPHA%NETPATH%TNFALPHA TNFalpha 13649 16367 18750 328572 20850 14886 12028 12369 17164 21353 15185 72416 71833 56399 56338 544963 333654 18789 56532 14084 12539 67338 67067 100039026 446099 17846 11652 13057 56710 109658 14113 19698 211651 76589 19414 14229 69807 192176 103583 16650 11647 20019 56407 56312 29864 12091 20340 15182 71966 69721 56480 22627 11797 11796 11798 16535 100039592 16648 433759 16709 15507 17218 11651 17220 14083 26408 26403 12912 76784 50754 17931 18037 20018 18567 18616 16476 18637 16477 245841 100043714 54391 58994 19645 320795 23938 66593 21402 19173 19179 26965 19181 19182 12389 70247 66513 21762 22123 17463 66997 26399 23997 228775 19708 12051 77045 67891 432502 27207 12122 68015 57751 80859 64424 20586 20587 20588 68094 57376 21926 21938 22026 22166 22628 56458 22642 22682 231130 236733 12366 20017 224619 18201 16151 26572 56456 12905 14082 21934 12633 52440 12455 70834 233406 53376 211550 50797 21941 226525 26413 67384 20016 26417 22032 56489 73174 66413 23881 227648 216150 26406 666899 16396 228026 26405 18854 68652 66724 67857 26420 73086 19696 22034 230233 15519 14694 14388 12048 20181 54401 107951 13867 13728 22629 12367 22033 100041766 66105 22196 12234 100039786 26410 12914 26416 13205 13448 14784 15516 18033 18035 18479 26419 19247 20662 20663 20779 20846 22631 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin 14388 54401 22629 13649 12367 13685 12015 14360 19353 18479 23844 12821 13684 109620 13844 16367 55948 13866 16403 192897 16418 11848 16773 16774 16776 22627 16777 16779 16780 226519 16782 16785 17126 11651 17127 14083 17295 11835 19882 18708 18753 18810 18750 20166 22352 213435 59079 18208 14281 12476 74769 16476 18707 18710 384783 22062 19247 22612 56717 100039786 20416 18706 20779 26416 22631 18709 30955 11350 14784 26413 26417 WNT%NETPATH%WNT Wnt 12443 54401 18019 13728 19353 216869 11848 18747 11651 18753 18750 18751 26419 16476 19052 17125 16842 18099 22612 16480 26409 226970 93687 13544 12550 13380 208846 67943 20378 14734 16971 16973 26563 18504 23988 19045 21416 84095 320790 77578 18752 12571 20377 20319 20664 13016 21413 22408 22413 22415 22418 14367 12005 14362 14366 14368 14369 14371 84035 330938 84505 18719 IL6%NETPATH%IL6 IL6 13163 26396 15519 17096 14388 14389 107951 13867 54601 18033 13685 12015 14360 19353 13684 16451 13866 17977 18803 433759 15507 11651 11835 18708 18753 15162 328572 56484 14281 26419 16476 26395 14191 19645 19247 18099 26409 26399 56637 20850 20416 20851 12914 20846 26416 22324 56458 18709 19229 54721 21939 229615 15382 16193 12402 16194 20848 16195 12229 26407 26398 12169 229317 20393 12702 14784 26413 26417 TSH%NETPATH%TSH TSH 26397 16001 26399 16846 12912 11928 14674 105782 14672 14673 14677 26417 14678 14679 14681 14828 22095 12317 16150 12330 110157 14682 EGFR1%NETPATH%EGFR1 EGFR1 13196 11949 67941 50766 72621 18596 54135 72201 18643 18738 67451 18805 18806 22038 74155 67760 109135 171463 212139 71889 216190 74255 321022 230837 19084 26362 18759 109333 66898 26400 19108 208618 19211 66166 76179 19246 19267 19268 19272 19279 58235 110078 13859 271457 64143 19730 245688 100043257 11461 19734 667618 667279 110651 67097 20194 20195 20239 394252 20969 20971 140579 71514 56726 20408 319939 381126 114479 20617 107686 109552 109880 20847 20909 11491 21815 21881 21894 21961 22051 22330 66395 60595 24066 223650 231002 21346 29815 69538 239250 20324 17974 226419 194655 226250 217169 107435 30794 12390 56455 109711 54366 19766 101320 29875 22687 73178 29806 208177 232431 54132 194590 66952 23942 14924 21873 225870 333883 20970 98910 238130 17775 330914 78388 50926 26396 72993 13548 433759 14083 18708 12912 14281 16476 20683 18607 20869 22059 12928 12389 26397 56637 218441 18706 13132 71770 56458 18709 26413 54601 16478 17869 12608 20218 67300 12929 26416 13205 13448 19229 286940 11350 232906 16818 16828 17096 17973 18003 11928 18033 18479 20403 11431 18648 240752 18746 18803 234779 170643 18753 18760 59079 23939 26419 26395 93742 140721 15170 19248 19262 110157 19697 53378 230126 22042 22323 22324 22325 22631 108705 640703 72828 227937 208650 11502 54126 19134 68481 13449 13549 26431 12534 105787 108079 20112 13649 13685 14360 606496 16451 13866 12568 20399 18127 12566 15461 18750 16452 12703 14786 20111 58194 16590 56717 20850 20851 13712 19253 30955 12371 26406 666899 16396 26420 73086 14388 54401 13867 12015 19353 12821 109620 13844 192897 11848 17126 17127 17295 18810 22352 74769 18707 18710 384783 16480 226970 12550 18752 13016 54721 229615 15382 26407 12702 105782 54473 53859 12043 20844 100040260 12606 17979 319152 11820 12558 12560 18571 71943 545878 24045 59026 74117 66713 15259 51789 14251 74326 236576 24063 24064 57783 21787 67938 108100 24105 70527 12631 20499 229709 107971 327826 19765 20867 399510 56460 69710 232910 12757 73379 19261 71544 12988 216810 13014 12388 218518 74256 11771 13209 53310 330662 13511 13628 13642 13645 13836 208643 13710 13714 13043 13806 56205 13835 13838 270190 13845 13846 11657 11674 240753 13855 229285 26936 98432 224650 23943 209039 22378 80794 14302 78757 235406 228136 104831 18938 14609 11352 26377 69178 19285 14783 50915 216963 15258 75454 26934 11740 227753 13854 16952 15194 11746 215114 628438 11804 16332 16337 16400 16412 11836 67859 11843 16653 110308 16687 110310 16691 16667 16668 11855 16835 210126 109904 17709 17886 17920 17999 23980 50932 ID%NETPATH%ID ID 15205 18507 19185 19650 66313 26396 21423 11910 12566 19651 17127 21416 13712 26413 26395 26417 19645 13714 13713 14200 110157 15903 17877 IL9%NETPATH%IL9 IL9 26413 54721 26417 20850 81601 16199 20851 20852 IL3%NETPATH%IL3 IL3 56637 17096 20416 14694 14388 14389 12125 12048 14461 20181 56461 54401 19401 12929 20525 216233 18033 12015 606496 13448 56458 22631 18709 18747 12984 14083 14159 18708 15461 18750 12912 12702 18751 26413 18707 26395 19052 15170 12928 16331 19264 100040260 IL5%NETPATH%IL5 IL5 56637 53378 26396 20850 17096 20416 14694 20851 20662 20846 12929 26416 20963 18783 18033 12387 13712 11689 18035 16191 16185 16192 13430 606496 20677 15163 16451 22631 30955 19229 12028 12402 20848 15461 18753 15162 56484 14784 107746 12703 16476 20111 22248 19247 11909 110157 IL4%NETPATH%IL4 IL4 17979 319152 18033 18035 12015 15077 320129 56463 16189 16451 16163 16164 20375 12767 16186 234779 11651 14083 18753 328572 16452 26419 12703 19094 18707 384783 15170 19247 11909 12608 218397 12675 23871 20416 18706 12914 26416 20963 13712 54721 21939 12402 20848 26413 26417 16150 16331 20844 12606 IL-7%NETPATH%IL-7 IL-7 56637 26396 20850 20416 20851 20846 12015 14360 606496 16367 56458 16186 16196 208650 11651 20848 18708 56484 26413 26417 26395 384783 16197 16453 20844 NOTCH%NETPATH%NOTCH Notch 15205 11820 21423 18033 15182 13389 14357 14199 56381 59287 20466 19664 16450 16848 11651 17127 17305 18129 18708 18132 18133 18550 50754 328572 100039623 16452 54485 55927 433586 100042305 19165 19763 27401 17125 22632 16842 208117 270118 60406 66935 21402 20185 20602 26965 103806 18519 56438 19697 56637 20779 20848 26413 26417 IL2%NETPATH%IL2 IL2 26396 15519 17096 14389 18033 13685 16185 14360 13684 667739 16367 16451 16186 12566 11651 18708 12912 56484 26419 74769 16476 18707 26395 18710 384783 15170 19247 11909 56717 12928 64685 56324 110157 16432 23872 18795 19697 14815 16183 16184 16168 230126 23871 22608 20850 20416 18762 20849 20851 18706 21752 20662 22349 17346 27979 12929 26416 12447 13712 22324 18709 30955 19229 12402 20393 12702 14784 26413 26417 12043 16453 20844 16818 TSLP%NETPATH%TSLP TSLP 26420 19697 20850 11651 20848 20849 20851 20852 20846 18034 19698 26416 18033 18035 26413 26419 26395 26417 13684 RANKL%NETPATH%RANKL RANKL 19696 22034 12675 14083 18034 18383 26416 11973 83433 18033 22029 26419 22030 22033 22031 21943 18412 17342 26409 20375 66513 68652 IL1%NETPATH%IL1 IL1 67857 26420 26397 19697 26399 19696 22034 230233 12675 26416 18783 18033 18035 73914 13448 16175 16176 16177 16181 16179 108960 17874 18709 266632 30839 93834 67245 667310 93765 66589 16178 11651 18708 26413 26419 16476 26417 19645 11909 16150 54473 53859 26405 66513 68652 66724 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis 12035 216136 12036 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway 15275 216019 19895 110208 21351 21881 14751 15277 ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation 14073 FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis 238505 17768 22171 270685 13361 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism 11676 11674 15275 16548 216019 230163 74246 14430 15277 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway 17260 26398 13684 17261 102626 26416 100040260 22034 17164 29857 15507 19094 26415 26399 269881 13712 56613 13631 73086 17346 16177 66513 26407 26409 68652 20807 17347 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway 102626 26416 17164 15507 26413 27371 26417 170758 22339 18710 110157 20698 75292 101540 21804 18127 216148 15251 19303 11836 109270 18704 240752 18751 107321 18783 18762 225326 15461 18761 18753 18754 18752 18755 18759 19354 30955 18708 18709 16542 18803 234779 18706 18750 74769 19353 18707 12954 26395 26396 56632 18176 18760 228359 109880 12955 73167 23871 12371 11651 14083 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway 20850 16155 20852 16154 16153 77799 20112 16188 16185 20728 16184 17869 16453 83430 384783 16165 12675 17164 16164 67071 16196 16195 16194 16193 12576 13712 16192 16169 16191 12575 17346 16168 16190 332110 16189 11652 110651 20807 17347 26413 26417 110157 18127 11836 18706 74769 18176 109880 11651 20111 50772 56484 23939 16150 20416 18607 16367 56717 20846 16183 20662 20848 13714 12765 227288 56637 23797 20663 14281 237313 20847 16173 20849 60505 16198 13713 20375 16175 16163 16162 16161 20851 100042555 16156 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis 54391 319945 HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis 12892 237926 97541 17025 22275 14151 107508 19044 67417 15288 70383 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway 11440 108015 108043 11444 110835 11438 110834 13491 13489 19045 192176 13822 269587 209195 210044 12288 19049 14677 14702 16527 223604 14688 214084 18747 12291 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system 18628 11865 12953 12952 12753 18626 18627 27373 104318 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis 17855 20775 68603 14593 56075 110196 14137 16987 192156 100040592 15357 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway 53623 14800 14799 110637 140919 14814 58234 14813 20511 14812 20510 14811 14810 20512 216227 14809 14802 20614 22320 20619 67474 22319 22317 14807 14806 14805 68159 242607 108069 108068 243961 20513 22318 74732 PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis 103711 107272 CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle 12444 12445 67236 12447 68240 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 12447 30955 11920 18708 12566 18709 19650 22059 320207 12387 18706 22061 22062 74769 19211 18707 26416 19052 19053 234129 16653 29857 12450 18176 19645 19094 18705 26415 20437 12575 11651 11652 18607 18710 23797 18704 240752 225326 15461 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis 208967 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation 268860 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway 18752 18755 18759 18803 234779 18750 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 16440 14701 16439 14675 18798 18799 15465 18802 14682 74055 16438 114875 14672 18751 14702 18762 14688 18761 18753 18754 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway 14814 14813 14812 14811 14810 18798 14809 14682 16438 14672 19084 19085 18749 108071 14805 14816 18751 66168 26556 19108 18747 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response 12043 16476 17347 20846 17260 26398 17869 26416 29857 19094 26415 26399 13712 18783 22166 13631 17187 13198 17346 26419 26397 26420 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway 14678 66066 11513 15557 19088 19087 15552 15551 15550 14681 14679 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 14701 18749 210044 14677 14702 19108 16527 223604 14688 18747 OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway 18752 18755 18759 18803 234779 18750 18430 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 14695 14693 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 18751 14702 18762 14688 18761 18753 18754 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway 14704 14696 14695 14693 11513 14709 14701 15562 14680 210044 14702 14697 14688 14710 14700 14708 14706 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling 66066 11513 19088 19087 14681 14679 104110 242425 16519 12286 54393 12287 224129 432530 11512 11514 11515 14710 14708 14706 14704 14696 14695 14693 14709 19084 19085 18749 210044 14677 14688 18747 12291 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway 56791 216080 22210 100041484 66105 100041766 68612 218793 22194 67196 620934 56459 50995 74153 22201 22193 22209 74244 53323 22195 93765 70620 22200 100039535 231380 22213 67128 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway 22068 93735 17356 14367 14365 11464 11465 11475 14314 16974 22415 12387 14362 16973 22413 22416 14366 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 13869 22408 57265 22419 12560 228357 93897 21416 22412 216795 66713 80890 22410 22414 22411 13542 19664 55992 58235 21415 22409 217127 12550 13544 13543 78943 238880 11459 22417 19668 94217 225372 16480 12505 11787 26946 16842 18128 11461 18129 18131 18132 56175 19164 19165 11820 56637 100042305 208117 23821 59287 81601 22063 22067 22066 16971 14725 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation 72535 17161 107747 109731 216188 19378 237320 69748 56847 56752 14204 11671 110695 11668 11669 212647 11670 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 22059 17246 17248 22061 26374 22062 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis 12035 216136 12036 ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization 68738 60525 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis 68087 211347 106564 269614 74450 75735 METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle 11428 64602 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation 26416 12675 29857 19094 26415 26413 16440 26417 16439 110157 16438 11836 18751 15461 26419 18753 26420 16476 19354 30955 234779 18706 74769 19353 18707 26395 26396 18176 16150 26414 57257 20662 15170 17096 22325 26405 19264 26406 22324 20663 640703 14281 20963 18038 17060 12229 14784 12518 12478 15985 12483 19055 19056 18035 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation 105787 11652 64930 108079 19079 108097 18518 22059 22061 22062 23797 19052 19053 11651 58988 13685 22084 19082 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis 16956 239759 18796 85031 18797 269060 18795 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism 69080 331026 29858 54128 110119 218138 MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing 66585 70767 53607 20639 22184 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation 11652 56717 23797 15251 11863 22346 12914 19885 56551 22166 112407 11651 112406 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism 29807 105663 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor 319944 14884 68705 98053 14894 68153 19088 74197 19087 12914 69833 245841 237336 14885 209357 21341 108143 66464 68776 20021 66653 22130 74238 72308 21343 328572 71828 229906 235459 24074 19084 83602 19085 100043714 407786 74044 66420 19183 21374 227606 208677 26427 208647 78284 63856 228980 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway 14704 14696 14678 14695 14693 11513 14709 14701 18386 18976 14681 14679 210044 14677 14702 14697 14688 14710 14700 14708 14706 BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation 13088 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis 76355 14583 14584 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis 11998 18429 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion 14645 266744 14661 UNTITLED%PANTHER PATHWAY%P00019 untitled 18796 18797 18795 11652 26413 16440 26417 16439 14675 18798 110157 14682 18127 16438 14672 19084 19085 11836 18749 210044 18751 18783 18762 18761 18747 18753 18754 18752 18755 18759 11513 19088 19087 18750 14680 104110 26395 26396 13615 13614 271639 13618 234889 224129 104111 432530 19091 11512 11514 54195 11515 60596 11651 19092 13617 13616 23797 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis 15186 TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis 14287 22171 14528 13361 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway 18752 18755 18759 66066 18803 234779 18750 18796 18797 18795 14697 14710 14700 14708 14706 14704 14696 15560 14695 15559 14693 15558 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 18751 14702 18762 14688 18761 18753 18754 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway 12831 16773 94216 12830 16774 241226 60595 11465 213119 225341 109711 11472 19248 16779 16780 226519 170736 16772 16782 78514 12841 12840 16775 16776 16777 319480 109905 223272 215449 286940 104303 228998 11858 140579 11840 12945 57342 16403 109700 16398 11845 11848 14268 373864 11852 53867 11853 104099 381924 16407 192176 16409 74194 223881 217378 238880 16400 16401 16402 16404 72065 192897 16419 74192 20130 26408 19229 16410 11461 16408 16412 12818 12927 16421 12816 12835 12834 12833 57764 22323 14360 67771 11867 56378 73368 76709 16420 21894 12817 71302 12815 12814 12813 16411 20779 56443 16414 12821 26414 26405 26406 26398 26415 26407 26417 18710 110157 19303 11836 18704 240752 225326 15461 26419 26397 26420 19354 30955 18708 18709 18706 74769 19353 18707 26395 26396 18176 109880 14083 50772 20416 107581 12819 16399 140580 13196 20662 12829 12828 12827 12826 12825 12824 12929 20663 107746 12928 16202 12843 23928 330662 320910 22330 12389 76108 74012 12839 329941 12837 12832 12988 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway 20850 20852 20112 17869 16453 12675 78514 67071 332110 11652 110651 71302 218397 17973 18590 18591 18595 18596 71520 14390 76117 26414 68797 57257 17974 19326 71544 22325 14247 26405 232441 259302 216445 22324 17444 69257 13709 606496 94190 13710 14784 78177 75415 13876 13875 171207 11855 11856 320119 58988 13711 56501 27049 30051 13661 56309 16451 260298 22282 18080 54153 230233 14389 320207 114713 14388 20418 109333 16452 117600 17164 13712 56613 73086 17346 26407 20807 17347 26413 16440 26417 16439 18710 110157 16438 216148 11836 225326 15461 26419 16476 30955 18708 18709 18803 234779 18706 18750 74769 18707 26395 26396 18176 228359 109880 73167 23871 20111 50772 23939 16150 20416 18607 20846 20662 20848 13714 56637 20663 14281 20847 20849 20851 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway 11464 11465 11475 140781 17885 17886 71960 329421 63993 20508 102857 667772 432516 17913 504186 54130 226977 17909 360013 11443 213603 110902 11435 17910 338367 71602 17918 17919 17920 17921 17922 270163 246177 17916 11449 208943 11448 11447 17912 238880 244281 11459 217198 231252 74376 667663 17879 544791 77579 17880 17882 17883 17884 11440 11461 17888 108015 108043 11444 110835 11438 110834 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway 20850 20852 16451 20849 20846 20848 16453 20851 16452 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism 192136 SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis 236539 100678 107272 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin 19354 107449 30955 69581 18708 18209 18709 226251 18021 18803 320207 73181 234779 57764 22253 18706 22323 18208 18019 74769 19353 80883 18707 13176 210801 18710 18704 240752 ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis 229706 102680 22598 381884 110877 13162 103098 20538 74338 214084 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation 13087 21743 22236 394433 14262 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism 192136 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis 238505 11720 232087 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase 11464 11465 11475 140781 17885 17886 71960 329421 11853 238880 11459 667663 17879 544791 77579 17880 17882 17883 17884 11461 17888 19354 69581 19353 67771 11867 56378 76709 56443 73710 545486 13367 16885 100042651 214230 107589 19877 18479 18481 224105 68089 22151 241656 22154 54004 18643 70584 18645 75477 213435 19878 22152 227613 22153 12632 12631 16765 228785 73178 67951 56471 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade 16004 16370 16002 16001 16000 16334 20112 16337 23920 384783 26395 26396 67071 13712 56613 73086 20111 218397 110651 26413 16367 26417 20662 110157 20663 14281 58988 26397 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway 16451 20846 15979 15980 15978 16452 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis 13195 21990 216343 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides 66757 331487 80914 22245 22271 68556 76654 18103 79059 56520 METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway 53611 56216 12295 14697 20907 14710 14823 14700 108073 14708 268934 14706 12290 14704 14696 14695 14693 14709 19084 19085 18749 108071 14816 14677 19108 14688 18747 14678 19088 19087 14679 12286 271639 12287 53623 14800 14799 110637 14814 14813 20511 14812 20510 14811 14810 20512 14809 14802 20614 22320 20619 67474 22319 22317 14807 14806 14805 242607 20513 22318 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway 16004 22059 26398 100040260 12675 11798 11652 12018 228355 19697 26413 19698 13804 26417 26926 12028 13665 26400 11910 11911 223922 19696 71609 14082 23992 21926 14939 225028 16994 53859 12125 14102 18751 14103 12048 19106 11783 16992 26419 12367 18761 26397 12124 18753 26408 26420 13163 18754 12043 26401 18752 66593 18755 16476 21937 21938 22035 30955 226641 26412 14943 81703 12369 18706 12370 18750 12915 74769 11909 19766 18707 11797 670717 12905 22030 18033 18034 26921 21933 11796 12371 11651 16150 26414 23797 14281 18035 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis 12035 12036 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway 20112 26398 102626 26416 16653 17164 29857 67071 19094 26415 26399 13712 26407 110651 20807 26413 26417 170758 11848 26400 110157 11852 11853 11836 225326 15461 26419 26397 26420 26401 16476 19354 30955 18706 74769 11909 19353 18707 26395 26396 18176 109880 19730 21844 18805 23871 18806 11651 56044 64143 20111 19731 66482 20416 18607 26414 20846 20662 18479 20848 18481 224105 56637 23797 20663 606496 14784 ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin 66066 18750 26395 26396 18796 13712 18797 18795 14697 14710 14700 14708 14706 110355 14704 320129 14696 13653 14695 11606 14693 11607 26413 14709 109689 16440 216869 26417 16439 110157 14682 16438 14688 GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation 319944 14884 68705 98053 14894 68153 74197 69833 245841 237336 14885 209357 21341 108143 66464 68776 20021 66653 22130 74238 72308 21343 71828 229906 235459 24074 83602 407786 63856 228980 P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway 12447 11920 12566 22059 18706 22061 22062 19211 234129 22030 12914 17246 17248 12575 11651 11652 18607 100043858 93759 12578 55948 12534 434174 20610 100043429 328572 23797 29870 17873 13197 18519 22427 433759 20466 23882 12532 23942 50883 18854 THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway 12297 12298 18796 18797 18795 12295 14697 14710 14700 14708 14706 12290 14704 14696 14695 14693 14709 14701 14675 18798 18799 18802 14682 74055 114875 14672 18751 14702 18762 14688 18761 18753 18754 18752 18755 18759 18803 234779 18750 12286 12287 20614 22320 20619 67474 22319 22317 12296 20908 22318 22044 22045 22094 12640 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis 20652 15486 15487 16889 15485 27400 13075 223920 15490 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway 93735 14367 14365 11464 11465 11475 14314 22415 14362 22413 22416 14366 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 22408 57265 22419 12560 93897 21416 22412 216795 66713 22410 22414 22411 21415 22409 12550 238880 11459 22417 16842 11461 12387 75599 93701 93706 54216 19246 233651 93893 93889 270120 93886 93891 18526 93887 93890 93892 12614 93884 93708 93876 93707 93874 93704 12943 12942 192161 93873 353237 353236 73173 192164 353235 170677 12939 12937 12941 18163 12388 12936 192163 353234 93881 116731 12558 23836 279653 245578 215654 320873 12565 12564 241201 12563 93872 12562 93724 12561 12552 268663 18530 211712 245827 14107 12557 12556 12555 12554 22295 219257 239096 11994 14158 104010 53601 93699 93723 93722 93703 93700 93716 93715 93714 93888 227485 93713 53883 107934 93711 93710 93709 UNTITLED%PANTHER PATHWAY%P06664 untitled 19697 20482 21815 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation 76507 237940 11754 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle 18598 66052 12974 14194 18293 18604 56451 11429 18597 17449 ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis 11947 11949 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation 54375 242669 18263 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion 66904 17850 52665 LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis 79464 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism 65254 23959 12934 64705 72269 268860 99586 103149 104776 22240 ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation 66646 BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway 14704 14696 14695 14693 11513 14709 14701 11554 19088 19087 14680 18749 210044 14702 19108 14697 14688 14710 14700 18747 14708 14706 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade 16004 16370 64930 16002 16001 18607 16367 16000 16334 16337 56458 23920 18706 19211 56637 384783 234129 606496 17246 17248 22084 56484 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway 14704 14696 14695 14693 11513 14709 14701 19088 19087 15466 14680 18749 210044 14702 19108 14697 14688 14710 14700 18747 14708 14706 BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway 14704 14696 14695 14693 11513 14709 14701 11556 14680 210044 14702 14697 14688 14710 14700 14708 14706 PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism 23959 14544 11717 22436 METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis 238505 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway 14704 14696 14695 14693 14709 14701 14675 18976 14682 12922 12921 14680 12918 14672 14702 14697 14688 14710 14700 14708 14706 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway 18752 18755 18759 56175 19164 19165 11820 18750 109333 26416 225724 319924 11784 29857 12289 54652 19094 12292 26415 74764 57267 320795 16594 12295 263803 232943 16593 11491 50772 332110 23939 26413 26417 26414 100042305 12288 208117 18751 23821 59287 81601 12296 18762 26419 18761 18753 26420 18754 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis 12411 AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo 19876 20563 11350 19354 20564 20562 20315 18209 57764 18208 19353 11853 80883 13176 117600 12767 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis 227231 69719 18103 114873 51797 56749 55936 18102 79059 56520 EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway 20850 20852 54153 320207 14389 26398 114713 14388 20418 26416 29857 19094 26415 26399 13869 26407 11652 26413 26417 26400 110157 75292 101540 208177 17532 13649 216148 210710 13867 13866 11836 69601 236576 18704 226525 240752 24066 18751 24064 18015 24063 18762 66922 225326 23980 15461 73523 26419 18761 20130 26397 18753 26408 26420 18754 18752 18755 18759 19354 30955 18803 234779 18706 18750 74769 19353 18707 26395 26396 18176 18760 109880 11651 218397 20416 71520 26414 20846 20662 20848 26405 26406 23797 20663 20847 20849 20851 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade 18816 17386 14161 83995 17395 18791 18792 18793 18815 17392 110135 99571 18787 18788 PNAT%PANTHER PATHWAY%P05912 PNAT 14678 66066 11513 19088 19087 13491 13488 14687 14679 13823 19047 13492 13162 14706 14704 14696 14695 14693 14709 20614 22320 13489 20619 19045 67474 192176 22319 13822 22317 269587 18749 209195 210044 19049 14677 19108 16527 20908 223604 14688 22318 214084 18747 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway 12234 269209 14634 19206 14632 319757 103583 12914 24069 20423 MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway 14678 66066 19088 19087 14681 14679 16519 271639 63993 20508 102857 14686 16521 14697 16522 14710 16524 14700 14685 14708 12672 14706 243764 14704 14696 14695 14693 14709 19084 19085 18749 14677 19108 14688 18747 N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism 26384 74091 245847 67980 14583 14584 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway 16324 18119 16323 110542 12705 320202 21809 21812 21813 17684 66313 242316 269275 17129 26416 17130 17131 55994 21808 29857 14573 238057 19094 319618 26415 14560 11477 11479 12914 11480 11481 11482 14106 14283 75788 66513 24087 21892 26409 14561 12153 20481 26413 26417 328572 15461 26419 20130 26420 16476 11909 18176 16477 20482 16478 26414 12154 16326 12163 12156 13590 110075 76793 12159 12160 12161 12162 12166 12167 23886 12168 14563 12155 17125 14562 17126 17127 17128 14566 17700 16325 12165 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation 14161 18791 18792 18793 18815 110135 22371 21788 21824 16399 14060 58992 14724 14723 385643 14058 14071 14069 217847 66901 19123 54368 19128 14729 14062 19124 14065 14068 14066 16621 14061 99571 PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway 14678 18708 16337 18709 56458 320207 18706 14679 74769 18176 14686 12371 14697 11651 14710 56484 11652 14696 14695 14693 18607 16367 14675 20662 18710 14682 56637 23797 20663 18127 14672 14677 14699 19216 14688 58988 54601 22631 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway 11554 15466 11556 109905 215449 14823 108073 268934 13489 210044 14677 14702 14688 18747 13491 13488 13492 16521 16522 16524 12672 243764 640703 606496 108069 108068 12914 14710 14700 14708 14706 14704 14693 14709 14701 15465 328572 19084 19085 18749 108071 14816 208677 14699 26427 208647 78284 68961 20605 20607 20606 14678 15566 15565 11513 15563 15557 18682 19088 67300 19087 18386 74325 15552 12757 15551 14715 15550 20609 20608 14679 14765 11539 15562 11540 14680 11541 104110 18387 110078 16519 18389 110095 19309 12671 224129 11542 432530 104111 12669 11512 11550 11514 12913 11515 213788 232493 14936 225192 17773 244701 15560 18679 15559 110094 15558 102093 99296 11552 11553 11548 11549 18390 12912 11555 56637 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway 54153 26398 114713 20418 26416 29857 19094 26415 26399 26407 11652 26413 26417 26400 110157 11836 236576 18704 240752 24066 18751 24064 24063 18762 225326 23980 15461 26419 18761 26397 18753 26408 26420 18754 18752 18755 18759 19354 30955 18803 234779 18706 18750 74769 19353 18707 26395 26396 18176 11651 218397 20416 71520 26414 20662 15170 26405 14182 107971 26406 53608 23797 14186 20663 14183 14184 327826 ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis 109900 18416 217214 227231 11898 69719 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction 20028 19739 18587 18588 14697 14710 14700 14685 14708 14706 14704 14696 14693 14709 14701 640703 64337 212541 14702 24013 225600 14699 12790 12788 14688 70405 30952 19674 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis 12035 12036 PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease 12447 20617 19171 18951 18952 100039786 21823 26446 12448 22628 22627 26416 19177 22629 100226 12361 29857 50873 53331 26443 13162 67847 26444 19170 13712 54401 18000 18806 26440 19166 19167 26441 26442 332110 171469 23939 72900 54204 14763 26413 26417 26414 55948 26419 22631 26420 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway 18752 18755 18759 66066 18750 109333 63993 20508 12671 12669 320795 263803 14697 14710 14700 14708 14706 14704 14814 14696 14695 14813 14693 14709 14812 16440 14811 16439 14810 14675 18798 14682 16438 14672 18751 18762 14688 18761 18753 18754 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway 14704 14696 14678 14695 18610 14693 18619 11513 14709 14701 18386 14679 210044 14677 14702 14697 14688 14710 14700 14708 14706 DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication 19075 19891 21973 21974 18538 19687 19718 18968 69263 319152 21969 327762 15081 106344 18971 72151 18972 METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway 73724 110821 66904 17850 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis 20135 20133 231327 75533 382985 11636 11637 229949 635960 229363 14450 54369 68870 79059 56520 18103 114873 18102 56248 171567 108147 100042069 11565 14923 11564 11566 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway 19401 14060 20181 22337 14473 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway 18796 18797 109905 18795 215449 14710 14823 14700 108073 14708 268934 14706 12290 14704 14696 14695 14693 14709 16440 14701 16439 14675 11848 18798 14682 13489 16438 14672 217378 108071 14816 18751 14702 18762 14699 14688 18761 18753 18754 20605 18752 20607 18755 20606 18759 18386 67300 13491 74325 12757 14715 20609 14681 18750 13488 20608 11539 11540 13492 11541 18387 19395 93690 18389 233046 12286 12061 12062 12287 12671 99326 11542 19419 12669 240168 110351 16801 213788 12672 243764 18390 64337 108069 108068 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis 14367 14365 14362 22413 22418 22422 22421 22408 57265 22419 11652 21416 22410 22414 11848 13542 19664 11852 11853 22409 13544 13543 19668 18128 26401 18129 18132 18805 18806 20779 13449 13388 50915 11799 218397 14786 17973 13448 18590 14164 18591 16449 18595 13389 18596 27261 71520 13386 13837 12005 78390 17974 13845 54635 13844 270190 21414 23805 232889 16450 21687 11600 71785 54485 11789 13642 13641 16451 26398 12387 102626 26416 17164 15507 26413 27371 26417 22339 18710 110157 20698 75292 101540 21804 18127 216148 15251 19303 11836 14062 109270 18704 240752 18751 107321 18783 18762 225326 15461 18761 26419 18753 18754 18752 18755 16476 18759 30955 18708 18709 16542 18803 234779 18706 18750 74769 18707 12954 26395 26396 56632 18176 18760 228359 109880 12955 73167 23871 12371 11651 14083 20416 20846 20662 18479 20848 18481 224105 14182 107971 56637 23797 12929 20663 14281 12928 327826 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis 20135 66757 20133 22171 382985 18103 21915 114873 110074 18102 79059 56520 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking 54524 171180 53420 13852 208898 54525 319508 20981 20980 20614 22317 56216 70450 19339 20907 22249 20910 20979 229521 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 56458 54401 110651 12028 11848 12550 53859 14702 12048 14688 214084 12367 18747 19229 16410 16412 12927 18792 17392 11909 20779 13653 216869 26414 17096 640703 14784 19055 18035 13685 252972 17260 26398 20613 12387 19247 13684 26403 17261 14919 667739 26416 16452 18125 233979 22034 12759 12424 15507 12426 110596 22026 15568 26399 12326 13712 21413 20192 20191 11640 20190 23938 67605 20687 12494 56233 20683 20807 22612 26413 19225 19016 26417 15937 12015 14459 15200 110157 101540 16438 19303 11836 18749 18751 18783 18761 26419 18753 18754 26420 12043 18755 16476 18708 18803 18750 74769 18019 19353 26395 26396 18760 109880 432530 19091 11651 14083 20111 56484 23939 20416 18607 16367 19877 20662 18479 20848 12912 13714 56637 14281 12928 18263 GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis 11674 12183 18746 18655 21991 18641 18642 56012 13806 13807 100043349 18770 15275 216019 14751 15277 NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway 18129 18131 16449 18132 13389 13386 19664 16450 54485 18222 66935 103806 19668 20602 18128 GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis 268860 14417 14415 246277 214579 FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway 14084 12368 16476 235587 11546 16905 16906 11545 328417 12332 12633 12369 26398 227753 12370 12371 26414 14082 14102 14103 11783 16907 26419 12367 13368 26408 20259 26420 13163 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway 11464 11465 11475 15978 12675 12361 12767 11652 19697 19698 11848 11853 238880 210044 11459 14677 14702 74192 20130 18747 19229 11461 16408 16412 12818 16421 12816 12835 12834 12833 67771 11867 56378 73368 76709 18034 56443 71520 16477 16478 22324 16452 140781 17885 16653 17886 71960 329421 18796 18797 18795 14700 14708 14706 14704 14695 22371 14709 26413 16440 14701 26417 16439 14675 18798 110157 18799 18802 14682 74055 16438 114875 14672 11836 18749 18751 667663 19108 17879 18762 544791 77579 17880 17882 17883 18754 17884 17888 16476 14678 19354 30955 18803 18021 234779 73181 18706 14681 56212 14679 74769 13051 18019 12769 19353 18707 18018 56744 54199 14294 14293 18176 12273 15975 54446 224129 15945 20303 11512 20304 20306 20296 20292 11651 277360 57260 20293 23832 20302 16150 12777 20416 20297 18607 100038965 12772 214230 20299 107589 12768 19877 16183 12766 20662 18479 12145 20848 18481 80901 224105 20312 12765 12776 68089 227288 12775 12458 241656 23797 12774 12773 12771 12322 70584 108058 213435 228785 XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway 18950 15452 14544 HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease 104215 110082 12333 12334 12335 12336 11464 12338 11465 13417 11475 54152 22059 29816 26398 13427 13426 22061 22062 73916 100042162 80837 76884 13424 66445 11771 11772 234663 12337 545156 269881 15194 12914 14447 68097 268958 20430 12339 23830 12064 20683 66713 26400 328572 100043349 238880 11459 21374 11783 74192 12367 26420 228980 11461 16476 19354 74325 12370 56212 19353 67771 11867 56443 110637 73710 545486 14814 14813 100042651 14812 14811 14810 14809 22151 22154 14281 14807 14806 56455 14805 381917 22152 110350 227613 215114 22153 432611 13385 15114 235661 13191 73647 67951 69543 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation 94041 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism 18563 18598 104112 17436 12974 69634 18770 18534 18746 18597 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation 12675 11652 26413 19057 26417 16797 12500 12501 18710 12502 110157 12503 16822 22637 16818 12487 12519 16438 12524 11836 225326 15461 26419 18761 26420 26401 16476 30955 18708 18709 18803 18706 74769 19353 18707 26395 26396 18176 109880 11651 17973 16150 57257 20662 17974 18479 18481 224105 22325 19264 23797 22324 17444 20663 640703 14281 19055 19056 18035 TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway 26410 56480 16476 26940 170744 266632 81897 26416 26395 22034 12675 26396 13712 66513 26409 16150 26417 17874 56489 117149 18037 54131 106759 54473 170743 21353 16179 21899 18035 21898 142980 26419 225471 26397 24088 26420 VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism 216134 103711 107272 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway 19057 14702 14688 67155 93761 20586 20585 20439 20588 20587 27373 13001 104318 13000 73016 12234 21372 70425 103236 93687 140577 75560 103583 12385 12386 68058 93762 216033 54380 59036 77578 20215 68094 83796 83797 57376 66993 68142 100043597 226849 225849 26931 21770 26932 84035 19058 19059 114606 170735 70315 81004 18099 93760 15183 21885 17125 21886 54366 21888 21887 17128 68911 15182 15201 72135 12387 17129 19052 19053 20437 18796 18797 18795 14700 14708 14706 14704 14696 14695 14693 14709 16440 14701 16439 14675 18798 14682 16438 14672 18021 73181 18019 64337 93735 14367 14365 14314 16974 22415 14362 16973 22413 22416 14366 22420 22418 22422 14370 14371 22421 14368 22423 14369 20890 22408 57265 22419 12560 93897 21416 22412 216795 22410 22414 22411 13542 21415 22409 12550 13544 13543 22417 16842 109689 216869 12005 433759 19055 19056 75599 93701 93706 54216 233651 93893 93889 270120 93886 93891 18526 93887 12914 93890 93892 12614 93884 93708 93876 93707 93874 93704 12943 12942 192161 93873 353237 353236 73173 192164 353235 170677 12939 12937 328572 12941 12936 192163 353234 93881 116731 12558 23836 18751 279653 245578 215654 18762 320873 12565 12564 18761 241201 18753 12563 18754 93872 18752 12562 18755 93724 18759 12561 12552 268663 18530 211712 245827 14107 12557 12556 18750 12555 12554 22295 219257 18018 239096 11994 104010 53601 93699 93723 93722 93703 93700 93716 93715 93714 93888 227485 93713 53883 107934 93711 93710 93709 56637 ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway 11821 18950 15452 22436 11486 TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism 15450 16890 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway 14678 66066 19088 19087 14681 14679 12286 271639 12287 56216 14686 12295 14697 20907 14710 14700 14708 12290 14706 14704 14696 14695 14693 14709 20614 22320 20619 67474 22319 19084 22317 19085 18749 14677 108069 19108 108068 14688 22318 18747 UNTITLED%PANTHER PATHWAY%P05916 untitled 14704 14696 14678 14695 18610 14693 11513 14709 14701 14681 14679 11998 18429 18387 210044 14677 14702 14697 14688 14710 14700 14708 14706 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins 65254 12934 20354 64705 19354 14302 18186 18844 235611 11848 26757 18479 20346 14159 12568 14360 12933 19353 16801 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling 14704 14696 14695 66066 14693 14709 14681 14679 12801 12286 12287 108071 14816 18796 14677 18797 18795 14688 14710 14708 14706 12291 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I 237336 21341 22130 21340 21339 21429 17749 20018 19285 106298 20017 19183 21374 227606 63856 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway 216134 103711 SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides 66757 72269 21877 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway 14704 14696 14695 14693 11513 14709 14701 19088 19087 11555 14680 18749 210044 14702 19108 14697 14688 14710 14700 18747 14708 14706 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release 14678 11513 19088 18386 19087 14681 14679 14680 14697 14710 14700 14708 14706 14704 14696 14695 18610 14693 18619 14709 14701 18390 12912 18749 210044 14677 14702 19108 14688 18747 ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis 27053 ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway 18752 11552 11553 11548 11549 18798 18750 74055 16438 14672 18796 11551 18797 18795 18753 18754 LOVASTATIN ACTION PATHWAY%SMPDB%SMP0000099 Lovastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 KANAMYCIN ACTION PATHWAY%SMPDB%SMP0000255 Kanamycin Action Pathway SEGAWA SYNDROME%PATHWHIZ%PW000466 Segawa Syndrome 110391 20751 13361 11677 12408 19286 320415 14528 TEMOCAPRIL ACTION PATHWAY%PATHWHIZ%PW000710 Temocapril Action Pathway 100038824 11606 11421 ALPRENOLOL ACTION PATHWAY%SMPDB%SMP0000297 Alprenolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 VATALANIB ACTION PATHWAY%SMPDB%SMP0000421 Vatalanib Action Pathway 16542 THE ONCOGENIC ACTION OF FUMARATE%PATHWHIZ%PW002363 The Oncogenic Action of Fumarate 55951 269951 112407 112406 66945 18563 67834 27376 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 ISRADIPINE ACTION PATHWAY%PATHWHIZ%PW000393 Isradipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 METHYLMALONIC ACIDURIA DUE TO COBALAMIN-RELATED DISORDERS%PATHWHIZ%PW000208 Methylmalonic Aciduria Due to Cobalamin-Related Disorders 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0120969 Ion Channel and Phorbal Esters Signaling Pathway 19229 18750 18803 18751 18442 THIOGUANINE METABOLISM PATHWAY%PATHWHIZ%PW000623 Thioguanine Metabolism Pathway 15452 PREDNISOLONE ACTION PATHWAY%SMPDB%SMP0000441 Prednisolone Action Pathway 14815 15519 CONGENITAL DISORDER OF GLYCOSYLATION CDG-IID%PATHWHIZ%PW000555 Congenital Disorder of Glycosylation CDG-IId 18103 14430 216558 76025 14377 66588 16770 22232 20525 14595 CD40L SIGNALLING PATHWAY%SMPDB%SMP0089759 CD40L Signalling Pathway 21939 21947 12675 230233 26416 26401 22034 18033 18035 16151 16150 22031 19252 21929 INOSITOL METABOLISM%SMPDB%SMP0087396 Inositol Metabolism 224020 228550 83493 56717 56208 18711 16329 71780 55980 66461 74769 56727 234729 269180 75669 69718 18798 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120804 Transaldolase Deficiency 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 CAPTOPRIL ACTION PATHWAY%SMPDB%SMP0000146 Captopril Action Pathway 100038824 11606 11421 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088271 Starch and Sucrose Metabolism 110006 223337 70974 14936 72157 11722 77559 14387 216558 22235 110095 14751 LEUKOTRIENE C4 SYNTHESIS DEFICIENCY%PATHWHIZ%PW000118 Leukotriene C4 Synthesis Deficiency 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PYRUVATE DECARBOXYLASE E1 COMPONENT DEFICIENCY (PDHE1 DEFICIENCY)%SMPDB%SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency) 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY II%PATHWHIZ%PW000517 Carnitine Palmitoyl Transferase Deficiency II 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%SMPDB%SMP0000177 Cystathionine beta-Synthase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 MEPYRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057583 Mepyramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CYCLOPHOSPHAMIDE ACTION PATHWAY%PATHWHIZ%PW000248 Cyclophosphamide Action Pathway 11670 107141 11668 14863 13114 13088 13087 72303 LORATADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061144 Loratadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THE ONCOGENIC ACTION OF D-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%SMPDB%SMP0002359 The Oncogenic Action of D-2-Hydroxyglutarate in Hydroxyglutaric aciduria 55951 217666 98314 216456 269951 66945 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 14661 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW121872 Glycogen Synthetase Deficiency 110006 22239 15275 14751 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0120959 T Cell Receptor Signaling Pathway 18750 18803 18751 20963 19353 16818 14784 16797 20416 26419 14281 110157 13712 15461 16476 26401 18708 26400 18033 14360 18035 26395 12313 19055 19697 26417 320139 19419 54446 22190 12502 12503 19056 12500 PENBUTOLOL ACTION PATHWAY%SMPDB%SMP0000305 Penbutolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 MIRTAZAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062885 Mirtazapine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 DOXORUBICIN METABOLISM PATHWAY%SMPDB%SMP0000650 Doxorubicin Metabolism Pathway 26357 18984 624814 18671 17250 22436 105349 19765 18104 75406 18127 58810 109857 12780 12408 70840 226646 CHOLESTERYL ESTER STORAGE DISEASE%SMPDB%SMP0000508 Cholesteryl Ester Storage Disease 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW122097 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 RUPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060235 Rupatadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AMMONIA RECYCLING%PATHWHIZ%PW000009 Ammonia Recycling 27053 11833 104174 14661 15109 13382 216456 227231 231691 66514 434437 14645 TYROSINEMIA, TRANSIENT, OF THE NEWBORN%PATHWHIZ%PW000470 Tyrosinemia, Transient, of the Newborn 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 HOMOCHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063751 Homochlorcyclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CHLORTHALIDONE ACTION PATHWAY%SMPDB%SMP0000122 Chlorthalidone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%SMPDB%SMP0063805 Cadmium Induces DNA Synthesis and Proliferation in Macrophages 18750 18795 18751 12289 54652 12292 26413 110157 15461 12288 18033 18035 26395 16438 19697 26417 CARTEOLOL ACTION PATHWAY%PATHWHIZ%PW000634 Carteolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 NATEGLINIDE ACTION PATHWAY%SMPDB%SMP0000453 Nateglinide Action Pathway 20927 16334 12286 20526 56808 12295 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%SMPDB%SMP0108012 Activation of PKC Through G Protein-Coupled Receptor 18750 18795 16438 14682 PHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056662 Pheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AMINO SUGAR METABOLISM%PATHWHIZ%PW000008 Amino Sugar Metabolism 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 DOXYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059730 Doxylamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PHOSPHATIDYLINOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000463 Phosphatidylinositol Phosphate Metabolism 18718 224020 103199 18795 16331 13649 56208 52858 18711 18704 225326 13866 18707 18720 228361 234515 234729 75669 18708 19211 64436 104015 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0120843 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000494 Glucose-6-phosphate Dehydrogenase Deficiency 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 SPERMIDINE AND SPERMINE BIOSYNTHESIS%PATHWHIZ%PW000037 Spermidine and Spermine Biosynthesis 671878 18263 232087 20810 108645 ANGIOTENSIN METABOLISM%SMPDB%SMP0000587 Angiotensin Metabolism 100038824 11606 11421 MITOCHONDRIAL COMPLEX II DEFICIENCY%PATHWHIZ%PW000524 Mitochondrial Complex II Deficiency 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 PYRUVALDEHYDE DEGRADATION%SMPDB%SMP0000459 Pyruvaldehyde Degradation 14651 109801 52815 FRUCTOSURIA%PATHWHIZ%PW122105 Fructosuria 21991 11674 14121 18641 20322 16548 11677 218138 69080 67883 29858 18639 110119 ADENYLOSUCCINATE LYASE DEFICIENCY%SMPDB%SMP0000167 Adenylosuccinate Lyase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 TOLMETIN ACTION PATHWAY%PATHWHIZ%PW000681 Tolmetin Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 GEMCITABINE ACTION PATHWAY%SMPDB%SMP0000446 Gemcitabine Action Pathway 63959 434203 13178 18102 50773 320685 66588 20135 20133 382985 22171 51797 114304 PHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000380 Phenytoin (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 13077 58226 394433 11928 71853 18747 69191 16521 12846 67838 98660 394434 16535 12304 12291 394436 16493 19035 330953 64136 16523 12282 20927 67397 16514 14828 20271 22004 13849 16519 94284 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 107141 13114 18104 13383 16511 20191 20928 246133 13106 232975 19084 20649 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW121883 Triosephosphate Isomerase Deficiency 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 LACTOSE SYNTHESIS%SMPDB%SMP0000444 Lactose Synthesis 18103 14430 216558 76025 14377 66588 16770 22232 20525 14595 PYRIMIDINE METABOLISM%PATHWHIZ%PW000160 Pyrimidine Metabolism 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 SHORT-CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (SCHAD)%PATHWHIZ%PW000544 Short-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency (SCHAD) 110446 15107 11409 15108 52538 93747 11363 TAMOXIFEN METABOLISM PATHWAY%PATHWHIZ%PW000582 Tamoxifen Metabolism Pathway 20887 13982 14262 13114 14261 394433 13088 56448 394434 PROTEIN SYNTHESIS: GLUTAMINE%SMPDB%SMP0111862 Protein Synthesis: Glutamine 20115 319195 67248 100043391 97541 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 VINCRISTINE ACTION PATHWAY%SMPDB%SMP0000437 Vincristine Action Pathway 224814 76408 12575 12780 18671 17250 545486 19765 22143 22059 PHENYLBUTAZONE ACTION PATHWAY%PATHWHIZ%PW000678 Phenylbutazone Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 VITAMIN A DEFICIENCY%SMPDB%SMP0000336 Vitamin A Deficiency 11668 13114 13087 13088 71853 69191 67838 12304 394436 19035 64136 12282 67397 14828 28200 67442 63857 235033 241452 13350 20148 79235 19378 622127 13113 77974 216454 17252 19892 245533 13082 BAMIPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062882 Bamipine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYPERPROLINEMIA TYPE I%SMPDB%SMP0000361 Hyperprolinemia Type I 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 OXYTETRACYCLINE ACTION PATHWAY%PATHWHIZ%PW000361 Oxytetracycline Action Pathway ALFENTANIL ACTION PATHWAY%PATHWHIZ%PW000419 Alfentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 REFSUM DISEASE%SMPDB%SMP0000451 Refsum Disease 16922 11671 26874 11666 26458 56794 MEVALONIC ACIDURIA%SMPDB%SMP0000510 Mevalonic Aciduria 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 TOBRAMYCIN ACTION PATHWAY%PATHWHIZ%PW000688 Tobramycin Action Pathway METHIONINE ADENOSYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000221 Methionine Adenosyltransferase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 FOSINOPRIL ACTION PATHWAY%PATHWHIZ%PW000227 Fosinopril Action Pathway 100038824 11606 11421 DIHYDROPYRIMIDINASE DEFICIENCY%SMPDB%SMP0000178 Dihydropyrimidinase Deficiency 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 DILTIAZEM ACTION PATHWAY%SMPDB%SMP0000359 Diltiazem Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 EUMELANIN BIOSYNTHESIS%SMPDB%SMP0121124 Eumelanin Biosynthesis 22173 13190 PHENYLALANINE AND TYROSINE METABOLISM%PATHWHIZ%PW000042 Phenylalanine and Tyrosine Metabolism 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 NALTREXONE ACTION PATHWAY%PATHWHIZ%PW000664 Naltrexone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HYPERLYSINEMIA II OR SACCHAROPINURIA%PATHWHIZ%PW000504 Hyperlysinemia II or Saccharopinuria 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 DIFLUNISAL ACTION PATHWAY%SMPDB%SMP0000289 Diflunisal Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 BENDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000329 Bendroflumethiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0120583 Glucose-6-phosphate Dehydrogenase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW122116 Fanconi-Bickel Syndrome 18642 15277 21991 14377 100043349 13806 18770 56012 319625 11674 14751 FRUCTOSE INTOLERANCE, HEREDITARY%SMPDB%SMP0120876 Fructose Intolerance, Hereditary 21991 11674 14121 18641 20322 16548 11677 218138 69080 67883 29858 18639 110119 AICA-RIBOSIDURIA%PATHWHIZ%PW000082 AICA-Ribosiduria 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 OMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000316 Omeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 PREDNISONE METABOLISM PATHWAY%PATHWHIZ%PW000607 Prednisone Metabolism Pathway 13114 RISEDRONATE ACTION PATHWAY%PATHWHIZ%PW000272 Risedronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PERINDOPRIL ACTION PATHWAY%SMPDB%SMP0000152 Perindopril Action Pathway 100038824 11606 11421 INTRACELLULAR SIGNALLING THROUGH FSH RECEPTOR AND FOLLICLE STIMULATING HORMONE%PATHWHIZ%PW000448 Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone 14701 14688 14309 12640 210044 18749 19045 12912 14699 AROMATIC L-AMINOACID DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000090 Aromatic L-Aminoacid Decarboxylase Deficiency 21823 18948 13195 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%SMPDB%SMP0121312 Glycerol Metabolism IV (Glycerophosphoglycerol) PHENYLACETATE METABOLISM%SMPDB%SMP0000126 Phenylacetate Metabolism 117147 107146 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%SMPDB%SMP0000560 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 DEZOCINE ACTION PATHWAY%PATHWHIZ%PW000653 Dezocine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 KIDNEY FUNCTION - DESCENDING LIMB OF THE LOOP OF HENLE%SMPDB%SMP0121009 Kidney Function - Descending Limb of the Loop of Henle 11826 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW002495 Inositol Phosphate Metabolism 55980 CARDIOLIPIN BIOSYNTHESIS (BARTH SYNDROME)%SMPDB%SMP0074684 Cardiolipin Biosynthesis (Barth Syndrome) 110911 66586 52123 66461 14732 74451 14555 GLYCOLYSIS%PATHWHIZ%PW000839 Glycolysis FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW122106 Fructose-1,6-diphosphatase Deficiency 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 TRAMADOL METABOLISM PATHWAY%PATHWHIZ%PW000613 Tramadol Metabolism Pathway 20517 12780 13114 13088 56448 394434 GLUCOSE TRANSPORTER DEFECT (SGLT2)%SMPDB%SMP0000184 Glucose Transporter Defect (SGLT2) 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 CIRCADIAN RHYTHMS%SMPDB%SMP0090831 Circadian Rhythms 12753 18160 18626 27373 12952 CREATINE DEFICIENCY, GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000480 Creatine Deficiency, Guanidinoacetate Methyltransferase Deficiency 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 METIAMIDE ACTION PATHWAY%PATHWHIZ%PW000712 Metiamide Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 APROTININ ACTION PATHWAY%SMPDB%SMP0000288 Aprotinin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 BCR SIGNALING PATHWAY%SMPDB%SMP0120964 BCR Signaling Pathway 18750 18803 18751 20963 19353 17060 16818 14784 17096 15985 20416 109305 26419 14281 110157 13712 15461 16476 26401 26395 12313 19055 26417 54446 19056 GLYCOGENOSIS, TYPE IB%SMPDB%SMP0000573 Glycogenosis, Type IB 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 ISOTHIPENDYL H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060659 Isothipendyl H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 EMEDASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061990 Emedastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 G-PROTEIN SIGNALING THROUGH TUBBY PROTEINS%PATHWHIZ%PW090863 G-Protein Signaling Through Tubby Proteins 14688 22141 18795 12669 15560 14699 14682 PROTEIN SYNTHESIS: GLUTAMIC ACID%PATHWHIZ%PW112922 Protein Synthesis: Glutamic Acid 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 107508 22121 65019 27050 27370 EPROSARTAN ACTION PATHWAY%PATHWHIZ%PW000279 Eprosartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 PROTEIN SYNTHESIS: PHENYLALANINE%PATHWHIZ%PW112934 Protein Synthesis: Phenylalanine 20115 319195 67248 23874 66590 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 LISINOPRIL ACTION PATHWAY%PATHWHIZ%PW000228 Lisinopril Action Pathway 100038824 11606 11421 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%PATHWHIZ%PW000507 Glycogenosis, Type VII. Tarui Disease 12183 14377 100043349 13806 319625 20526 56012 11674 14751 18648 18642 18655 15277 18770 ACETAMINOPHEN METABOLISM PATHWAY%PATHWHIZ%PW000616 Acetaminophen Metabolism Pathway 13077 13114 13087 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 94284 20859 14871 27416 239273 231396 20860 20887 26357 56448 18671 17250 13106 PHENYLTOLOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059850 Phenyltoloxamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THREONINE AND 2-OXOBUTANOATE DEGRADATION%SMPDB%SMP0000452 Threonine and 2-Oxobutanoate Degradation 12039 12040 66904 110821 13171 13382 231691 17850 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%PATHWHIZ%PW000519 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 CELECOXIB ACTION PATHWAY%SMPDB%SMP0000096 Celecoxib Action Pathway 71519 14775 208285 17001 19223 13850 13114 100040843 13088 13110 16993 11684 394434 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 56448 12408 72303 14598 13106 72054 66469 CHONDRODYSPLASIA PUNCTATA II, X-LINKED DOMINANT (CDPX2)%SMPDB%SMP0000388 Chondrodysplasia Punctata II, X-Linked Dominant (CDPX2) 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW101384 Protein Synthesis: Alanine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 234734 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 METHYLMALONATE SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000384 Methylmalonate Semialdehyde Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GLYCINE AND SERINE METABOLISM%SMPDB%SMP0000004 Glycine and Serine Metabolism 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 FRUCTOSE METABOLISM%PATHWHIZ%PW000913 Fructose Metabolism VINDESINE ACTION PATHWAY%SMPDB%SMP0000438 Vindesine Action Pathway 224814 76408 12575 12780 18671 17250 545486 19765 22143 22059 FEXOFENADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060218 Fexofenadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CIMETIDINE ACTION PATHWAY%SMPDB%SMP0000232 Cimetidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 INDOMETHACIN ACTION PATHWAY%PATHWHIZ%PW000260 Indomethacin Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 CLINDAMYCIN ACTION PATHWAY%PATHWHIZ%PW000347 Clindamycin Action Pathway BUCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058964 Buclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AZATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059865 Azatadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ALKAPTONURIA%PATHWHIZ%PW000180 Alkaptonuria 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 MITOCHONDRIAL ELECTRON TRANSPORT CHAIN%SMPDB%SMP0000355 Mitochondrial Electron Transport Chain 66043 11950 14571 17708 66945 11947 670717 100039108 66925 11949 22273 54405 100043349 11739 14385 17705 11946 67680 66052 VITAMIN K METABOLISM%SMPDB%SMP0000464 Vitamin K Metabolism 56316 18104 27973 LIDOCAINE (LOCAL ANAESTHETIC) METABOLISM PATHWAY%SMPDB%SMP0000620 Lidocaine (Local Anaesthetic) Metabolism Pathway 20266 20264 13077 13114 27-HYDROXYLASE DEFICIENCY%PATHWHIZ%PW000697 27-Hydroxylase Deficiency 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 BIOTIN METABOLISM%SMPDB%SMP0000066 Biotin Metabolism 69019 110948 100705 26363 CARBAMOYL PHOSPHATE SYNTHETASE DEFICIENCY%SMPDB%SMP0000002 Carbamoyl Phosphate Synthetase Deficiency 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 ISOVALERIC ACIDEMIA%PATHWHIZ%PW000500 Isovaleric Acidemia 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 QUINAPRIL ACTION PATHWAY%SMPDB%SMP0000153 Quinapril Action Pathway 100038824 11606 11421 OXAPROZIN ACTION PATHWAY%PATHWHIZ%PW000262 Oxaprozin Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 GALACTOSE METABOLISM%SMPDB%SMP0000043 Galactose Metabolism 11677 72157 74246 14430 226413 216558 12091 14387 11605 15275 14377 14595 FELBAMATE METABOLISM PATHWAY%SMPDB%SMP0000633 Felbamate Metabolism Pathway 11670 13114 13106 HYDROMORPHONE ACTION PATHWAY%PATHWHIZ%PW000416 Hydromorphone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW122619 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088368 Inositol Phosphate Metabolism 228550 71780 55980 234515 217837 75678 269180 23827 17330 56409 27399 170835 69718 BUTYRATE METABOLISM%PATHWHIZ%PW000014 Butyrate Metabolism 110446 15107 11409 93747 15356 117147 67041 CITRIC ACID CYCLE%SMPDB%SMP0000057 Citric Acid Cycle 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 HYPERINSULINISM-HYPERAMMONEMIA SYNDROME%PATHWHIZ%PW000072 Hyperinsulinism-Hyperammonemia Syndrome 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 BIVALIRUDIN ACTION PATHWAY%SMPDB%SMP0000277 Bivalirudin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 DIPHENOXYLATE ACTION PATHWAY%SMPDB%SMP0000675 Diphenoxylate Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CYPROHEPTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059694 Cyproheptadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PHOSPHOENOLPYRUVATE CARBOXYKINASE DEFICIENCY 1 (PEPCK1)%PATHWHIZ%PW121880 Phosphoenolpyruvate Carboxykinase Deficiency 1 (PEPCK1) 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 MEVALONATE PATHWAY%SMPDB%SMP0121055 Mevalonate Pathway 110446 68603 100040592 319554 14137 16987 192156 15357 17855 110196 20775 BENZOCAINE ACTION PATHWAY%SMPDB%SMP0000392 Benzocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOLYSIS I%SMPDB%SMP0002312 Glycolysis I 18746 21991 100043349 56421 14751 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW122063 Glucose-6-phosphate Dehydrogenase Deficiency 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 PHOSPHOLIPID BIOSYNTHESIS%SMPDB%SMP0000025 Phospholipid Biosynthesis 18777 12660 14571 13026 192654 19210 52858 12647 56209 13139 18618 66461 14732 74451 14555 66586 19012 320951 18782 237928 74596 18806 55979 27388 FUMARASE DEFICIENCY%SMPDB%SMP0000547 Fumarase Deficiency 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 DISOPYRAMIDE ACTION PATHWAY%SMPDB%SMP0000325 Disopyramide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ALTERNATIVE COMPLEMENT PATHWAY%SMPDB%SMP0063815 Alternative Complement Pathway 11537 109828 230558 12279 15139 14962 18636 12266 12274 NAPROXEN ACTION PATHWAY%SMPDB%SMP0000120 Naproxen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 FLUOXETINE METABOLISM PATHWAY%SMPDB%SMP0000646 Fluoxetine Metabolism Pathway 107141 13114 56448 15567 BETAXOLOL ACTION PATHWAY%SMPDB%SMP0000299 Betaxolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 SPHINGOLIPID METABOLISM%PATHWHIZ%PW088482 Sphingolipid Metabolism 11605 268656 14466 22239 18605 22234 20773 67630 53418 56632 230379 242285 223753 70059 HYPERPHENYLALANINEMIA DUE TO 6-PYRUVOYLTETRAHYDROPTERIN SYNTHASE DEFICIENCY (PTPS)%SMPDB%SMP0000488 Hyperphenylalaninemia Due to 6-Pyruvoyltetrahydropterin Synthase Deficiency (ptps) 110391 20751 13361 11677 12408 19286 320415 14528 CYCLOTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000103 Cyclothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLUCONEOGENESIS%PATHWHIZ%PW064594 Gluconeogenesis 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122107 Triosephosphate Isomerase Deficiency 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 DEGRADATION OF SUPEROXIDES%PATHWHIZ%PW000020 Degradation of Superoxides 20656 667310 12359 22178 20657 NEBIVOLOL ACTION PATHWAY%SMPDB%SMP0000366 Nebivolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 IRINOTECAN ACTION PATHWAY%PATHWHIZ%PW000238 Irinotecan Action Pathway 104158 12038 21969 13114 436059 26357 71853 69191 18671 67838 17250 394434 12304 394436 19035 64136 12282 67397 14828 12780 BROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058500 Brompheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 KETOTIFEN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060812 Ketotifen H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LOSARTAN ACTION PATHWAY%PATHWHIZ%PW000282 Losartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 CETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059995 Cetirizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HEPARIN ACTION PATHWAY%SMPDB%SMP0000274 Heparin Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 SPIRAPRIL ACTION PATHWAY%SMPDB%SMP0000156 Spirapril Action Pathway 100038824 11606 11421 WARBURG EFFECT%SMPDB%SMP0086930 Warburg Effect 69719 55951 13806 104112 66945 67834 64602 66925 18663 20501 20916 12183 14194 15275 18293 27402 15926 11428 15929 14751 14447 17449 18746 67680 239606 66052 12974 18642 12040 19895 14661 14782 14660 100198 21351 110208 83553 11676 PREDNISONE ACTION PATHWAY%SMPDB%SMP0000440 Prednisone Action Pathway 13114 HARTNUP DISORDER%SMPDB%SMP0000189 Hartnup Disorder 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 ASTEMIZOLE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059897 Astemizole H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 VINORELBINE ACTION PATHWAY%SMPDB%SMP0000439 Vinorelbine Action Pathway 224814 76408 12575 12780 13114 18671 17250 545486 19765 22143 22059 METHDILAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059730 Methdilazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 GROWTH HORMONE SIGNALING PATHWAY%PATHWHIZ%PW064811 Growth Hormone Signaling Pathway 18750 18803 16337 20851 26413 16367 16334 15170 12703 20528 14784 14600 20111 20416 20662 20850 16452 110157 15461 26395 26417 KIDNEY FUNCTION - COLLECTING DUCT%PATHWHIZ%PW122278 Kidney Function - Collecting Duct 20276 11931 11932 20277 11933 11928 98660 11827 110935 27411 20533 100038824 11828 12346 20278 232975 ATORVASTATIN ACTION PATHWAY%SMPDB%SMP0000131 Atorvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 GLYCEROL PHOSPHATE SHUTTLE%SMPDB%SMP0000124 Glycerol Phosphate Shuttle 14571 100043349 14555 NEPAFENAC ACTION PATHWAY%PATHWHIZ%PW000679 Nepafenac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 RANITIDINE ACTION PATHWAY%SMPDB%SMP0000230 Ranitidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 DOPA-RESPONSIVE DYSTONIA%SMPDB%SMP0000486 DOPA-Responsive Dystonia 110391 20751 13361 11677 12408 19286 320415 14528 2-KETOGLUTARATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000525 2-Ketoglutarate Dehydrogenase Complex Deficiency 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 QUINETHAZONE ACTION PATHWAY%SMPDB%SMP0000091 Quinethazone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 LEIGH SYNDROME%SMPDB%SMP0000196 Leigh Syndrome 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 DASATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032594 Dasatinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 INOSITOL METABOLISM%PATHWHIZ%PW064607 Inositol Metabolism 225326 18707 74055 66461 101490 234729 75669 16332 218441 277360 XIMELAGATRAN ACTION PATHWAY%SMPDB%SMP0000279 Ximelagatran Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PROTEIN SYNTHESIS: VALINE%PATHWHIZ%PW120528 Protein Synthesis: Valine 20115 22321 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 FAS SIGNALING PATHWAY ( CD95 )%PATHWHIZ%PW070709 FAS signaling pathway ( CD95 ) 13163 12368 19090 16905 16906 14082 12633 26409 18479 11545 11857 12370 12367 13347 19645 26419 12369 26398 19249 224105 16907 26401 16476 13368 14102 20740 14103 192656 14084 ANTAZOLINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057584 Antazoline H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CINNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059110 Cinnarizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MEBHYDROLIN H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061052 Mebhydrolin H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PACLITAXEL ACTION PATHWAY%PATHWHIZ%PW000239 Paclitaxel Action Pathway 12780 26357 18671 17250 28253 545486 22143 PRIMARY HYPEROXALURIA TYPE I%SMPDB%SMP0000352 Primary Hyperoxaluria Type I 76282 11611 55951 18563 224805 HYPERPHENYLALANINEMIA DUE TO DHPR-DEFICIENCY%PATHWHIZ%PW000465 Hyperphenylalaninemia Due to DHPR-Deficiency 110391 20751 13361 11677 12408 19286 320415 14528 GALACTITOL AND GALACTONATE DEGRADATION%SMPDB%SMP0000840 Galactitol and Galactonate Degradation CALVIN-BENSON CYCLE%PATHWHIZ%PW012957 Calvin-Benson Cycle 19895 21991 66646 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW122231 g-Secretase Mediated ErbB4 Signalling Pathway 13867 18750 11491 19164 100042150 13869 RAMIPRIL ACTION PATHWAY%SMPDB%SMP0000154 Ramipril Action Pathway 100038824 11606 11421 FONDAPARINUX ACTION PATHWAY%SMPDB%SMP0000273 Fondaparinux Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 IBUPROFEN ACTION PATHWAY%SMPDB%SMP0000086 Ibuprofen Action Pathway 71519 14775 208285 17001 107141 19223 13850 13114 100040843 13088 13110 71853 16993 69191 11684 67838 106648 394434 105349 12304 64292 394436 19215 19035 11689 64136 11686 12282 21391 67397 11687 14828 11688 19224 19225 18399 22236 19879 12408 71773 72303 14598 13106 72054 66469 KIDNEY FUNCTION- PROXIMAL CONVOLUTED TUBULE%SMPDB%SMP0121001 Kidney Function- Proximal Convoluted Tubule 30962 20532 54403 20544 11826 69354 50934 18399 20510 12346 102680 20518 20540 330836 17254 20539 IBANDRONATE ACTION PATHWAY%SMPDB%SMP0000079 Ibandronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY (APRT)%PATHWHIZ%PW000511 Adenine Phosphoribosyltransferase Deficiency (APRT) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 EPO SIGNALING PATHWAY%PATHWHIZ%PW070692 EPO Signaling Pathway 18803 13856 13857 15170 14784 20416 20662 26419 20850 14281 16452 110157 13712 15461 16476 26395 26417 CODEINE METABOLISM PATHWAY%PATHWHIZ%PW000597 Codeine Metabolism Pathway 13114 56448 18390 RAMIPRIL METABOLISM PATHWAY%SMPDB%SMP0000597 Ramipril Metabolism Pathway 11421 LATREPIRDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062623 Latrepirdine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088265 Pentose Phosphate Pathway 14381 18641 19895 72157 66646 230163 21881 232449 19139 66171 14751 14121 HOP PATHWAY IN CARDIAC DEVELOPMENT%SMPDB%SMP0090879 Hop Pathway in Cardiac Development 18091 14463 20807 74318 GLUTATHIONE METABOLISM%SMPDB%SMP0000015 Glutathione Metabolism 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 GAUCHER DISEASE%PATHWHIZ%PW000201 Gaucher Disease 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 GABA-TRANSAMINASE DEFICIENCY%SMPDB%SMP0000351 GABA-Transaminase Deficiency 14415 268860 104776 11669 64705 99586 11754 103149 338403 PANCREAS FUNCTION - BETA CELL%PATHWHIZ%PW122285 Pancreas Function - Beta Cell 14688 56508 18750 22318 18795 16440 19339 55984 14652 271639 12286 20526 20927 14702 56808 14682 12671 12295 LANSOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000317 Lansoprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 6 AND SEROTONIN%SMPDB%SMP0000312 Excitatory Neural Signalling Through 5-HTR 6 and Serotonin 14688 18749 19045 12912 14699 15565 METHADONE METABOLISM PATHWAY%SMPDB%SMP0000624 Methadone Metabolism Pathway 107141 13114 13088 56448 72303 18390 13113 14811 14810 PENTAZOCINE ACTION PATHWAY%SMPDB%SMP0000686 Pentazocine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MECLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059891 Meclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 SELENOAMINO ACID METABOLISM%PATHWHIZ%PW000007 Selenoamino Acid Metabolism 107869 216443 232087 20768 23971 269378 67547 67011 14598 12411 50880 108645 GLYCOGENOSIS, TYPE VI. HERS DISEASE%PATHWHIZ%PW000531 Glycogenosis, Type VI. Hers Disease 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 ETHYLMORPHINE ACTION PATHWAY%SMPDB%SMP0000681 Ethylmorphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCEROL METABOLISM II%PATHWHIZ%PW122618 Glycerol Metabolism II INTRACELLULAR SIGNALLING THROUGH PGD2 RECEPTOR AND PROSTAGLANDIN D2%SMPDB%SMP0000343 Intracellular Signalling Through PGD2 receptor and Prostaglandin D2 14688 19214 210044 18749 14699 DICLOFENAC ACTION PATHWAY%PATHWHIZ%PW000135 Diclofenac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 MOEXIPRIL METABOLISM PATHWAY%SMPDB%SMP0000595 Moexipril Metabolism Pathway 11421 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW002481 Starch and Sucrose Metabolism 66681 14376 14936 216019 15275 74185 14751 PHENYLKETONURIA%PATHWHIZ%PW000119 Phenylketonuria 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 FOSPHENYTOIN (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000379 Fosphenytoin (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BUPRENORPHINE ACTION PATHWAY%SMPDB%SMP0000684 Buprenorphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 LYSOPHOSPHATIDIC ACID LPA4 SIGNALLING%SMPDB%SMP0063756 Lysophosphatidic Acid LPA4 Signalling 14688 18795 11651 19877 432530 78134 20807 16438 14702 NADOLOL ACTION PATHWAY%PATHWHIZ%PW000371 Nadolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ARGATROBAN ACTION PATHWAY%SMPDB%SMP0000276 Argatroban Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TRAMADOL ACTION ACTION PATHWAY%SMPDB%SMP0000671 Tramadol Action Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 LYSOSOMAL ACID LIPASE DEFICIENCY (WOLMAN DISEASE)%PATHWHIZ%PW000099 Lysosomal Acid Lipase Deficiency (Wolman Disease) 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 SIALURIA OR FRENCH TYPE SIALURIA%SMPDB%SMP0000216 Sialuria or French Type Sialuria 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 ISOBUTYRYL-COA DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000523 Isobutyryl-CoA Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 THIAMINE METABOLISM%SMPDB%SMP0000076 Thiamine Metabolism 29807 105663 116914 66566 TERFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061157 Terfenadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CONGENITAL LIPOID ADRENAL HYPERPLASIA (CLAH) OR LIPOID CAH%SMPDB%SMP0000371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 CARNITINE-ACYLCARNITINE TRANSLOCASE DEFICIENCY%PATHWHIZ%PW000493 Carnitine-Acylcarnitine Translocase Deficiency 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 CHLORPHENOXAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059836 Chlorphenoxamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 NIZATIDINE ACTION PATHWAY%SMPDB%SMP0000233 Nizatidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%PATHWHIZ%PW000918 Glycerol Metabolism V (Glycerophosphoserine) FABRY DISEASE%SMPDB%SMP0000525 Fabry Disease 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 17-BETA HYDROXYSTEROID DEHYDROGENASE III DEFICIENCY%SMPDB%SMP0000356 17-beta Hydroxysteroid Dehydrogenase III Deficiency 13075 54200 100559 13074 20860 78925 208665 15497 15487 15485 ARGININEMIA%PATHWHIZ%PW000183 Argininemia 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 CANAVAN DISEASE%SMPDB%SMP0000175 Canavan Disease 27053 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 CADMIUM INDUCES DNA SYNTHESIS AND PROLIFERATION IN MACROPHAGES%PATHWHIZ%PW109282 Cadmium Induces DNA Synthesis and Proliferation in Macrophages 18750 18795 110157 18751 15461 18033 18035 26413 26395 16438 19697 26417 LEVOBUNOLOL ACTION PATHWAY%SMPDB%SMP0000666 Levobunolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 MEXILETINE ACTION PATHWAY%PATHWHIZ%PW000382 Mexiletine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 STREPTOMYCIN ACTION PATHWAY%SMPDB%SMP0000259 Streptomycin Action Pathway DISULFIRAM ACTION PATHWAY%PATHWHIZ%PW000431 Disulfiram Action Pathway 11670 12359 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 68738 60525 72535 11669 13106 GROWTH HORMONE SIGNALING PATHWAY%SMPDB%SMP0120947 Growth Hormone Signaling Pathway 18750 18803 26413 20851 16334 16367 15170 20528 14784 14600 20111 20416 20850 16452 110157 15461 14599 26395 26417 3-HYDROXYISOBUTYRIC ACIDURIA%PATHWHIZ%PW000498 3-Hydroxyisobutyric Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 ALANINE METABOLISM%SMPDB%SMP0000055 Alanine Metabolism 76282 11611 55951 18563 224805 MALONYL-COA DECARBOXYLASE DEFICIENCY%PATHWHIZ%PW000478 Malonyl-CoA Decarboxylase Deficiency 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 CONGENITAL LACTIC ACIDOSIS%PATHWHIZ%PW000522 Congenital Lactic Acidosis 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE DEFICIENCY%PATHWHIZ%PW000063 3-Hydroxy-3-methylglutaryl-CoA Lyase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GALACTOSEMIA III%SMPDB%SMP0000496 Galactosemia III 72157 74246 67883 14430 216558 22235 103988 14635 PHOSPHOLIPASE C SIGNALING PATHWAY%SMPDB%SMP0063783 Phospholipase C Signaling Pathway 18750 18795 18803 11651 22324 30955 104709 INDAPAMIDE ACTION PATHWAY%SMPDB%SMP0000110 Indapamide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 NAD+ SIGNALLING AND AGING%SMPDB%SMP0084271 NAD+ Signalling and Aging 192185 19017 226518 93759 12753 59027 18160 66454 18104 74080 19883 CONGENITAL ERYTHROPOIETIC PORPHYRIA (CEP) OR GUNTHER DISEASE%SMPDB%SMP0000345 Congenital Erythropoietic Porphyria (CEP) or Gunther Disease 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 7 AND SEROTONIN%SMPDB%SMP0000311 Excitatory Neural Signalling Through 5-HTR 7 and Serotonin 14688 18749 15566 19045 12912 14699 PREDNISOLONE METABOLISM PATHWAY%PATHWHIZ%PW000608 Prednisolone Metabolism Pathway 14815 15519 UREA CYCLE%PATHWHIZ%PW000162 Urea Cycle 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0000374 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 IBUPROFEN METABOLISM PATHWAY%PATHWHIZ%PW000566 Ibuprofen Metabolism Pathway 107141 22236 19879 13114 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 19224 19225 71773 18399 72303 GLYCOLYSIS%SMPDB%SMP0087391 Glycolysis 18746 18648 21991 15275 100043349 13806 56012 319625 20525 56421 14751 STRIATED MUSCLE CONTRACTION%PATHWHIZ%PW000564 Striated Muscle Contraction 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 IMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000601 Imipramine Metabolism Pathway 107141 20538 13077 13114 56448 15567 AMIODARONE ACTION PATHWAY%PATHWHIZ%PW000642 Amiodarone Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 100040287 16520 19088 11554 215999 16518 67821 12288 19085 20541 19087 20650 56543 16525 16509 56808 12295 18749 20544 13383 16511 20191 20928 246133 232975 19084 20649 CHLOROPROCAINE ACTION PATHWAY%SMPDB%SMP0000394 Chloroprocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 IMIPRAMINE ACTION PATHWAY%SMPDB%SMP0000422 Imipramine Action Pathway 20266 11931 15550 11932 11549 107141 18549 11933 20264 13077 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 KETOROLAC ACTION PATHWAY%SMPDB%SMP0000098 Ketorolac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NICOTINE METABOLISM PATHWAY%PATHWHIZ%PW000604 Nicotine Metabolism Pathway 14262 394433 13088 13087 11761 11444 110834 11438 394434 CARNITINE SYNTHESIS%SMPDB%SMP0000465 Carnitine Synthesis 20425 56752 170442 73251 192289 FAMILIAL LIPOPROTEIN LIPASE DEFICIENCY%PATHWHIZ%PW000506 Familial Lipoprotein Lipase Deficiency 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 ETHYLMALONIC ENCEPHALOPATHY%PATHWHIZ%PW000106 Ethylmalonic Encephalopathy 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 TIAPROFENIC ACID ACTION PATHWAY%PATHWHIZ%PW000682 Tiaprofenic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 BUMETANIDE ACTION PATHWAY%SMPDB%SMP0000088 Bumetanide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLYCEROL METABOLISM%PATHWHIZ%PW000914 Glycerol Metabolism BCR-ABL ACTION IN CML PATHOGENESIS%SMPDB%SMP0031692 BCR-ABL Action in CML Pathogenesis 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 GLUTAMATE METABOLISM%PATHWHIZ%PW000003 Glutamate Metabolism 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 XANTHINURIA TYPE I%SMPDB%SMP0000512 Xanthinuria Type I 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0000554 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 AZATHIOPRINE ACTION PATHWAY%SMPDB%SMP0000427 Azathioprine Action Pathway 63959 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000185 Glutaric Aciduria Type I 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 GLUTARIC ACIDURIA TYPE I%SMPDB%SMP0000186 Glutaric Aciduria Type I 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 BETAZOLE ACTION PATHWAY%PATHWHIZ%PW000713 Betazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 TENOFOVIR METABOLISM PATHWAY%PATHWHIZ%PW000606 Tenofovir Metabolism Pathway 11636 18103 18102 11637 3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000718 3-beta-Hydroxysteroid Dehydrogenase Deficiency 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 MERCAPTOPURINE ACTION PATHWAY%PATHWHIZ%PW000267 Mercaptopurine Action Pathway 63959 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 CYSTEINE METABOLISM%PATHWHIZ%PW000018 Cysteine Metabolism 107869 14630 14718 14629 12583 83429 27267 246221 16828 MEFENAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000261 Mefenamic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 EGF SIGNALLING PATHWAY%SMPDB%SMP0063810 EGF Signalling Pathway 18750 18803 13649 18751 14784 20416 26419 14281 26398 110157 13712 15461 26401 16476 26395 26417 20807 20847 20846 20848 16451 100039026 13645 20662 218397 20852 FOLATE METABOLISM%SMPDB%SMP0000053 Folate Metabolism 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087296 Fructose and Mannose Degradation 21991 11674 14121 18641 20322 16548 11677 218138 69080 67883 29858 18639 110119 BEPOTASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060058 Bepotastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ARBEKACIN ACTION PATHWAY%PATHWHIZ%PW000690 Arbekacin Action Pathway FAMOTIDINE ACTION PATHWAY%SMPDB%SMP0000231 Famotidine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 MAGNESIUM SALICYLATE ACTION PATHWAY%PATHWHIZ%PW000675 Magnesium Salicylate Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 GAMMA-CYSTATHIONASE DEFICIENCY (CTH)%PATHWHIZ%PW000490 gamma-Cystathionase Deficiency (CTH) 107869 12411 VITAMIN B6 METABOLISM%PATHWHIZ%PW000053 Vitamin B6 Metabolism 57028 216134 11647 103711 11761 NUCLEOTIDE SUGARS METABOLISM%SMPDB%SMP0087384 Nucleotide Sugars Metabolism 72157 74246 67883 69976 14430 216558 22235 15275 EMBRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062622 Embramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ATENOLOL ACTION PATHWAY%SMPDB%SMP0000298 Atenolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 RESCINNAMINE ACTION PATHWAY%SMPDB%SMP0000155 Rescinnamine Action Pathway 100038824 11606 11421 PROPIONIC ACIDEMIA%PATHWHIZ%PW000062 Propionic Acidemia 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 5-OXOPROLINASE DEFICIENCY%PATHWHIZ%PW000476 5-Oxoprolinase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 PROTEIN SYNTHESIS: METHIONINE%PATHWHIZ%PW112933 Protein Synthesis: Methionine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 216443 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 GLUCONEOGENESIS FROM L-MALIC ACID%SMPDB%SMP0000839 Gluconeogenesis from L-Malic Acid CAPECITABINE METABOLISM PATHWAY%SMPDB%SMP0000607 Capecitabine Metabolism Pathway 434203 104158 72269 72962 22171 DEXBROMPHENIRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058503 Dexbrompheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 RIBOFLAVIN METABOLISM%SMPDB%SMP0000070 Riboflavin Metabolism 18605 22173 54391 319945 11431 ACETYLSALICYLIC ACID ACTION PATHWAY%PATHWHIZ%PW000128 Acetylsalicylic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 MORPHINE ACTION PATHWAY%PATHWHIZ%PW000412 Morphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 71853 69191 67838 98660 394434 12304 394436 19035 64136 12282 67397 14828 231396 56808 12295 22236 12286 13162 71773 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MITOCHONDRIAL BETA-OXIDATION OF SHORT CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000171 Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids 110446 15107 11409 15108 52538 93747 11363 ORNITHINE TRANSCARBAMYLASE DEFICIENCY (OTC DEFICIENCY)%SMPDB%SMP0000205 Ornithine Transcarbamylase Deficiency (OTC Deficiency) 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 PROPRANOLOL ACTION PATHWAY%SMPDB%SMP0000307 Propranolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FATTY ACID METABOLISM%PATHWHIZ%PW000023 Fatty Acid Metabolism 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 VALINE, LEUCINE, AND ISOLEUCINE DEGRADATION%PATHWHIZ%PW000051 Valine, Leucine, and Isoleucine Degradation 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 3-METHYLGLUTACONIC ACIDURIA TYPE I%SMPDB%SMP0000139 3-Methylglutaconic Aciduria Type I 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 DIMETINDENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057582 Dimetindene H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PLASMALOGEN SYNTHESIS%PATHWHIZ%PW000170 Plasmalogen Synthesis 19012 14712 99712 228061 55979 SULFITE OXIDASE DEFICIENCY%PATHWHIZ%PW000508 Sulfite Oxidase Deficiency 58250 54200 20887 23827 211389 23972 CARNITINE PALMITOYL TRANSFERASE DEFICIENCY I%PATHWHIZ%PW000514 Carnitine Palmitoyl Transferase Deficiency I 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 BENAZEPRIL ACTION PATHWAY%SMPDB%SMP0000145 Benazepril Action Pathway 100038824 11606 11421 CIMETIDINE METABOLISM PATHWAY%PATHWHIZ%PW000593 Cimetidine Metabolism Pathway 15466 CELECOXIB METABOLISM PATHWAY%SMPDB%SMP0000644 Celecoxib Metabolism Pathway 19224 19225 13114 56448 394434 ADEFOVIR DIPIVOXIL METABOLISM PATHWAY%PATHWHIZ%PW000605 Adefovir Dipivoxil Metabolism Pathway 11636 18103 18102 11637 CHILD SYNDROME%PATHWHIZ%PW000096 CHILD Syndrome 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 TREHALOSE DEGRADATION%PATHWHIZ%PW000169 Trehalose Degradation 20537 11931 11932 58866 11933 11928 103988 98660 20526 232975 PYRUVATE METABOLISM%PATHWHIZ%PW000054 Pyruvate Metabolism 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 HYPERPROLINEMIA TYPE II%SMPDB%SMP0000360 Hyperprolinemia Type II 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 CITALOPRAM METABOLISM PATHWAY%PATHWHIZ%PW000603 Citalopram Metabolism Pathway 109731 107141 17161 56448 15567 11761 13113 ACETAMINOPHEN ACTION PATHWAY%SMPDB%SMP0000710 Acetaminophen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 TORSEMIDE ACTION PATHWAY%PATHWHIZ%PW000338 Torsemide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 2-AMINOADIPIC 2-OXOADIPIC ACIDURIA%SMPDB%SMP0000719 2-Aminoadipic 2-Oxoadipic Aciduria 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 FENTANYL ACTION PATHWAY%PATHWHIZ%PW000421 Fentanyl Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLUCOSE-ALANINE CYCLE%SMPDB%SMP0000127 Glucose-Alanine Cycle 76282 69354 55963 68267 14661 108682 20526 20528 GEMCITABINE METABOLISM PATHWAY%PATHWHIZ%PW000579 Gemcitabine Metabolism Pathway 63959 434203 13178 18102 50773 320685 66588 20135 20133 382985 22171 51797 114304 WARBURG EFFECT%PATHWHIZ%PW000630 Warburg Effect 55951 100043349 216456 13806 56012 66171 18655 18770 16828 20514 66945 18563 67834 56451 66925 20501 209692 20917 11429 13382 14194 230163 235339 21881 20526 68263 15926 170718 11428 18597 14751 15929 78920 14381 17449 18641 18746 67680 66052 12974 19895 14661 15277 21351 110208 ENALAPRIL METABOLISM PATHWAY%SMPDB%SMP0000593 Enalapril Metabolism Pathway 11421 TAY-SACHS DISEASE%PATHWHIZ%PW000215 Tay-Sachs Disease 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 BOSUTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032596 Bosutinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 WARBURG EFFECT%SMPDB%SMP0087527 Warburg Effect 55951 18598 229699 20511 74419 100043349 216456 13806 18655 66945 67834 18563 56451 209692 20917 11429 14194 13382 235339 68263 170718 15926 56421 11428 14751 17449 14381 18746 67680 12974 14661 19895 15277 21351 110208 HYPERMETHIONINEMIA%SMPDB%SMP0000341 Hypermethioninemia 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 G(M2)-GANGLIOSIDOSIS: VARIANT B, TAY-SACHS DISEASE%SMPDB%SMP0000534 G(M2)-Gangliosidosis: Variant B, Tay-Sachs Disease 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 KANDUTSCH-RUSSELL PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121060 Kandutsch-Russell Pathway (Cholesterol Biosynthesis) 66234 235293 18194 98386 13121 13360 15490 13595 74754 ARGININE AND PROLINE METABOLISM%SMPDB%SMP0000020 Arginine and Proline Metabolism 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 LYMECYCLINE ACTION PATHWAY%SMPDB%SMP0000295 Lymecycline Action Pathway LEVALLORPHAN ACTION PATHWAY%SMPDB%SMP0000683 Levallorphan Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 FLUVASTATIN ACTION PATHWAY%PATHWHIZ%PW000274 Fluvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 STAT3 SIGNALING PATHWAY%PATHWHIZ%PW068597 Stat3 Signaling Pathway 56717 26413 54721 20848 16451 IBUTILIDE ACTION PATHWAY%SMPDB%SMP0000332 Ibutilide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 HEROIN METABOLISM PATHWAY%PATHWHIZ%PW000599 Heroin Metabolism Pathway 104158 12038 436059 18390 INOSITOL METABOLISM%PATHWHIZ%PW088478 Inositol Metabolism 69718 56208 225326 71780 55980 66461 234729 242291 18706 104015 18798 12462 ADENOSINE DEAMINASE DEFICIENCY%PATHWHIZ%PW000075 Adenosine Deaminase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 RAS SIGNALING PATHWAY%SMPDB%SMP0063784 Ras Signaling Pathway 670717 19353 19765 18706 11783 57257 11848 12675 12371 110157 56044 13712 54601 15461 11651 18805 19730 12048 17127 17128 26395 12015 26417 PANTOPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000318 Pantoprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 PIRENZEPINE ACTION PATHWAY%SMPDB%SMP0000246 Pirenzepine Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 ORPHENADRINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059735 Orphenadrine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 EBASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061153 Ebastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ALDOSTERONE FROM STEROIDOGENESIS%SMPDB%SMP0121126 Aldosterone from Steroidogenesis 14688 13070 11607 13079 15497 14702 14682 13072 SPIRONOLACTONE ACTION PATHWAY%SMPDB%SMP0000134 Spironolactone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0000520 Transaldolase Deficiency 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 CATECHOLAMINE BIOSYNTHESIS%SMPDB%SMP0000012 Catecholamine Biosynthesis 21823 18948 13195 ERLOTINIB ACTION PATHWAY%PATHWHIZ%PW000251 Erlotinib Action Pathway 13649 26357 18671 NIFEDIPINE ACTION PATHWAY%PATHWHIZ%PW000394 Nifedipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BETA-MERCAPTOLACTATE-CYSTEINE DISULFIDURIA%SMPDB%SMP0000499 beta-Mercaptolactate-Cysteine Disulfiduria 107869 14630 14718 14629 12583 83429 27267 246221 16828 ETHACRYNIC ACID ACTION PATHWAY%SMPDB%SMP0000097 Ethacrynic Acid Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLYCOLYSIS AND PYRUVATE DEHYDROGENASE%SMPDB%SMP0000807 Glycolysis and Pyruvate Dehydrogenase CHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000078 Chlorothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 ABCIXIMAB ACTION PATHWAY%SMPDB%SMP0000265 Abciximab Action Pathway 16416 16399 BENAZEPRIL METABOLISM PATHWAY%SMPDB%SMP0000591 Benazepril Metabolism Pathway 11421 LEVORPHANOL ACTION PATHWAY%SMPDB%SMP0000673 Levorphanol Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 LYSOPHOSPHATIDIC ACID LPA5 SIGNALLING%SMPDB%SMP0063757 Lysophosphatidic Acid LPA5 Signalling 14688 18795 11651 19877 432530 20807 16438 381810 14702 MEPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000405 Mepivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MELOXICAM ACTION PATHWAY%SMPDB%SMP0000106 Meloxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 METHYCLOTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000327 Methyclothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 IFOSFAMIDE ACTION PATHWAY%PATHWHIZ%PW000249 Ifosfamide Action Pathway 11670 11668 13114 13088 13087 72303 BILE ACID DIRECT SIGNALLING PATHWAY (2)%PATHWHIZ%PW090771 Bile Acid Direct Signalling Pathway (2) 14652 227289 20494 NALOXONE ACTION PATHWAY%SMPDB%SMP0000688 Naloxone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 UROKINASE ACTION PATHWAY%SMPDB%SMP0000284 Urokinase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 INSULIN SIGNALLING%PATHWHIZ%PW000454 Insulin Signalling 56458 384783 18607 16337 26413 16367 16334 20528 14784 20416 20662 26419 110157 15461 11651 26395 30955 104709 26396 SUPROFEN ACTION PATHWAY%SMPDB%SMP0000101 Suprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 HYDROCHLOROTHIAZIDE ACTION PATHWAY%SMPDB%SMP0000100 Hydrochlorothiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 PYRUVATE KINASE DEFICIENCY%PATHWHIZ%PW000535 Pyruvate Kinase Deficiency 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 PROTEIN SYNTHESIS: LEUCINE%SMPDB%SMP0111873 Protein Synthesis: Leucine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 107045 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0087496 Inositol Phosphate Metabolism 69718 327655 71780 55980 242291 56409 27399 104015 WARFARIN ACTION PATHWAY%SMPDB%SMP0000268 Warfarin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 GLUCONEOGENESIS FROM L-MALIC ACID%PATHWHIZ%PW002518 Gluconeogenesis from L-Malic Acid 17449 TIMOLOL ACTION PATHWAY%PATHWHIZ%PW000636 Timolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ADRENOLEUKODYSTROPHY, X-LINKED%PATHWHIZ%PW000492 Adrenoleukodystrophy, X-Linked 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 ANTIPYRINE ACTION PATHWAY%SMPDB%SMP0000692 Antipyrine Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 HYDROXYETHYLPROMETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059710 Hydroxyethylpromethazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYPERCHOLESTEROLEMIA%PATHWHIZ%PW000221 Hypercholesterolemia 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 INOSITOL METABOLISM%SMPDB%SMP0002397 Inositol Metabolism 56208 18802 225326 55980 234729 75669 104015 DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY (DHPD)%SMPDB%SMP0000179 Dihydropyrimidine Dehydrogenase Deficiency (DHPD) 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%PATHWHIZ%PW121901 Glycogenosis, Type IA. Von Gierke Disease 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 TOCAINIDE ACTION PATHWAY%SMPDB%SMP0000330 Tocainide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 ALTEPLASE ACTION PATHWAY%PATHWHIZ%PW000302 Alteplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TIROFIBAN ACTION PATHWAY%PATHWHIZ%PW000293 Tirofiban Action Pathway 16416 16399 GAMMA-GLUTAMYLTRANSPEPTIDASE DEFICIENCY%SMPDB%SMP0000501 gamma-Glutamyltranspeptidase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 TICLOPIDINE ACTION PATHWAY%SMPDB%SMP0000261 Ticlopidine Action Pathway 70839 FAMILIAL HYPERCHOLANEMIA (FHCA)%PATHWHIZ%PW000194 Familial Hypercholanemia (FHCA) 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 IMINOGLYCINURIA%PATHWHIZ%PW000219 Iminoglycinuria 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 FLURBIPROFEN ACTION PATHWAY%SMPDB%SMP0000697 Flurbiprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 DOPAMINE ACTIVATION OF NEUROLOGICAL REWARD SYSTEM%PATHWHIZ%PW000440 Dopamine Activation of Neurological Reward System 210044 18749 13488 LAFUTIDINE H2-ANTIHISTAMINE ACTION%PATHWHIZ%PW051946 Lafutidine H2-Antihistamine Action 20608 12346 15466 11944 11945 20604 14459 12426 12671 CARBAMAZEPINE METABOLISM PATHWAY%PATHWHIZ%PW000610 Carbamazepine Metabolism Pathway 107141 13849 13114 13088 72303 13113 P53 SIGNALING PATHWAY%PATHWHIZ%PW064774 P53 Signaling Pathway 12043 12566 12534 12447 13555 17873 12443 18538 12028 11783 19645 12567 12575 METOLAZONE ACTION PATHWAY%SMPDB%SMP0000105 Metolazone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW122096 Glycogen Synthetase Deficiency 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 OXATOMIDE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059044 Oxatomide H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 COMPLEMENT PATHWAY%PATHWHIZ%PW064819 Complement Pathway 230558 12279 15139 14962 12266 12274 11537 12258 109828 625018 12259 12260 12262 667277 317677 12263 17195 17175 MIZOLASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060230 Mizolastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PHENINDAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062141 Phenindamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LYSINURIC PROTEIN INTOLERANCE%SMPDB%SMP0000197 Lysinuric Protein Intolerance 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 UBIQUITIN–PROTEASOME PATHWAY%SMPDB%SMP0063816 Ubiquitin–Proteasome Pathway 19166 19167 26441 56424 26442 22194 23997 24108 19185 22201 26445 26446 19172 19173 19175 19177 67089 26443 26444 19170 19179 22190 19181 19182 23996 19184 26440 D-GLYCERIC ACIDURA%PATHWHIZ%PW000505 D-Glyceric Acidura 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 GNRH SIGNALING PATHWAY%SMPDB%SMP0120949 GnRH Signaling Pathway 18750 18795 18751 14784 26419 110157 13712 15461 60595 16476 26401 14714 18805 14715 26400 14672 17390 26395 224129 12322 12313 17387 14308 16866 13869 20779 11911 13653 12640 242274 12540 15200 26413 16438 CAFFEINE METABOLISM%SMPDB%SMP0000028 Caffeine Metabolism 17960 13077 13114 13087 72303 22436 13106 ANILERIDINE ACTION PATHWAY%SMPDB%SMP0000674 Anileridine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CODEINE ACTION PATHWAY%PATHWHIZ%PW000411 Codeine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HYPERLYSINEMIA I, FAMILIAL%PATHWHIZ%PW000503 Hyperlysinemia I, Familial 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 ADRENAL HYPERPLASIA TYPE 3 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 RETEPLASE ACTION PATHWAY%SMPDB%SMP0000285 Reteplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW000702 Fructose Intolerance, Hereditary 234730 75454 22122 21991 75540 331026 15275 230163 11674 14121 18641 20322 11677 16548 218138 29858 18639 110119 BUPRANOLOL ACTION PATHWAY%SMPDB%SMP0000670 Bupranolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PROPOXYPHENE ACTION PATHWAY%PATHWHIZ%PW000649 Propoxyphene Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOLYSIS%PATHWHIZ%PW088465 Glycolysis 18746 15277 100043349 13806 56421 14751 BCR SIGNALING PATHWAY%PATHWHIZ%PW070885 BCR Signaling Pathway 18750 18803 18751 20963 19353 17060 14784 17096 15985 109305 20416 26419 14281 110157 13712 15461 26401 16476 26395 19055 26417 19056 12229 12518 18021 73181 18018 18019 20662 19057 640703 22324 LYSOPHOSPHATIDIC ACID LPA1 SIGNALLING%SMPDB%SMP0063746 Lysophosphatidic Acid LPA1 Signalling 14688 18795 14745 11651 19877 432530 20807 16438 14702 PROCAINE ACTION PATHWAY%PATHWHIZ%PW000408 Procaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOGENOSIS, TYPE IC%SMPDB%SMP0000574 Glycogenosis, Type IC 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 OLOPATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060740 Olopatadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 KETONE BODY METABOLISM%PATHWHIZ%PW000028 Ketone Body Metabolism 110446 71911 15356 67041 ASPARTATE METABOLISM%SMPDB%SMP0000067 Aspartate Metabolism 27053 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 LUMIRACOXIB ACTION PATHWAY%SMPDB%SMP0000699 Lumiracoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NILOTINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032595 Nilotinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 STREPTOKINASE ACTION PATHWAY%PATHWHIZ%PW000304 Streptokinase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TENIPOSIDE METABOLISM PATHWAY%SMPDB%SMP0000602 Teniposide Metabolism Pathway 17523 13114 21973 PHOSPHATIDYLCHOLINE BIOSYNTHESIS%SMPDB%SMP0014212 Phosphatidylcholine Biosynthesis 12660 13026 68671 18618 320951 99712 HYPERORNITHINEMIA WITH GYRATE ATROPHY (HOGA)%PATHWHIZ%PW000481 Hyperornithinemia with Gyrate Atrophy (HOGA) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 INOSITOL METABOLISM%PATHWHIZ%PW088261 Inositol Metabolism 224020 228550 83493 56208 16329 71780 228361 55980 66461 217837 56727 234729 75669 17330 18706 12462 18799 APOPTOTIC DNA FRAGMENTATION AND TISSUE HOMEOSTASIS%SMPDB%SMP0063772 Apoptotic DNA Fragmentation and Tissue Homeostasis 12369 69719 21973 97165 434174 14939 13804 12367 13347 GLYCEROL METABOLISM II%PATHWHIZ%PW000915 Glycerol Metabolism II GLUCONEOGENESIS%SMPDB%SMP0087318 Gluconeogenesis 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 CLEMASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059823 Clemastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 EPTIFIBATIDE ACTION PATHWAY%PATHWHIZ%PW000292 Eptifibatide Action Pathway 16416 16399 CYCLIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059857 Cyclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ACTIVATION OF CAMP-DEPENDENT PROTEIN KINASE, PKA%SMPDB%SMP0063764 Activation of cAMP-dependent protein kinase, PKA 14688 18749 19088 14699 271639 18747 19085 19087 19084 GLUCONEOGENESIS%PATHWHIZ%PW000152 Gluconeogenesis 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 ZELLWEGER SYNDROME%PATHWHIZ%PW000195 Zellweger Syndrome 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 ANISTREPLASE ACTION PATHWAY%PATHWHIZ%PW000303 Anistreplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PROTEIN SYNTHESIS: LYSINE%SMPDB%SMP0111874 Protein Synthesis: Lysine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 85305 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 DICUMAROL ACTION PATHWAY%PATHWHIZ%PW000313 Dicumarol Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088490 Pentose Phosphate Pathway 14381 72157 19895 71336 74419 21351 66646 232449 56421 19139 14751 14121 TYROSINEMIA TYPE I%PATHWHIZ%PW000182 Tyrosinemia Type I 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 TOLPROPAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062621 Tolpropamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 GLYCOGEN SYNTHETASE DEFICIENCY%PATHWHIZ%PW000528 Glycogen Synthetase Deficiency 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%PATHWHIZ%PW121876 Mucopolysaccharidosis VII. Sly Syndrome 110006 22239 15275 14751 CLASSICAL COMPLEMENT PATHWAY%PATHWHIZ%PW065057 Classical Complement Pathway 230558 12279 15139 12266 12274 109828 625018 12259 12260 12262 667277 317677 12263 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0000581 Glycogenosis, Type IA. Von Gierke Disease 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 GLYCOLYSIS%PATHWHIZ%PW088241 Glycolysis 12183 21991 100043349 14377 13806 230163 56012 319625 20526 14751 18746 18648 18642 FRUCTOSE METABOLISM%SMPDB%SMP0012445 Fructose Metabolism 20322 15275 11674 18640 14121 CHLOROPYRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058510 Chloropyramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PIMETHIXENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062886 Pimethixene H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ALCAFTADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062881 Alcaftadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 REPAGLINIDE ACTION PATHWAY%SMPDB%SMP0000454 Repaglinide Action Pathway 20927 16334 12286 20526 56808 12295 STARCH AND SUCROSE METABOLISM%SMPDB%SMP0063673 Starch and Sucrose Metabolism 110006 22239 15275 14751 NICOTINATE AND NICOTINAMIDE METABOLISM%PATHWHIZ%PW000151 Nicotinate and Nicotinamide Metabolism 192185 67375 78914 226518 18113 225994 12182 59027 67993 76952 11761 18605 18950 18115 SALSALATE ACTION PATHWAY%SMPDB%SMP0000707 Salsalate Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 TELITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000350 Telithromycin Action Pathway TYROSINE METABOLISM%SMPDB%SMP0000006 Tyrosine Metabolism 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 ACUTE INTERMITTENT PORPHYRIA%PATHWHIZ%PW000174 Acute Intermittent Porphyria 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 PORPHYRIA VARIEGATA (PV)%SMPDB%SMP0000346 Porphyria Variegata (PV) 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 ISOPRENALINE ACTION PATHWAY%SMPDB%SMP0000663 Isoprenaline Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 AMLODIPINE ACTION PATHWAY%PATHWHIZ%PW000391 Amlodipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PIROXICAM ACTION PATHWAY%SMPDB%SMP0000077 Piroxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 CILAZAPRIL METABOLISM PATHWAY%SMPDB%SMP0000592 Cilazapril Metabolism Pathway 11421 ACRIVASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060826 Acrivastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FRUCTOSE METABOLISM%PATHWHIZ%PW002390 Fructose Metabolism 20322 15275 18640 14751 ETOPOSIDE ACTION PATHWAY%SMPDB%SMP0000442 Etoposide Action Pathway 13114 21974 71853 69191 18671 67838 12304 394436 19035 64136 12282 76408 67397 14828 19224 17523 19225 21973 IMATINIB INHIBITION OF BCR-ABL%SMPDB%SMP0031694 Imatinib Inhibition of BCR-ABL 17869 56717 18671 14784 22059 20662 20850 16452 20517 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 SALLA DISEASE INFANTILE SIALIC ACID STORAGE DISEASE%SMPDB%SMP0000240 Salla Disease Infantile Sialic Acid Storage Disease 15275 54342 245847 109785 67311 12764 50798 107652 56174 14583 235504 15211 71884 26384 94181 74091 19703 DIBUCAINE ACTION PATHWAY%SMPDB%SMP0000396 Dibucaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROLINEMIA TYPE II%PATHWHIZ%PW000087 Prolinemia Type II 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 TRYPTOPHAN METABOLISM%SMPDB%SMP0000063 Tryptophan Metabolism 12359 107766 70560 56720 98256 71562 22375 21990 11298 70789 266645 13195 21743 13076 23923 15930 11669 LPS AND CITRATE SIGNALING AND INFLAMMATION%PATHWHIZ%PW101069 LPS and Citrate Signaling and Inflammation 17436 104112 66945 66925 56421 17449 67680 66052 12675 12475 12974 117149 17087 21898 22034 13358 18033 17874 18035 16151 16150 19697 107476 HYPERGLYCINEMIA, NON-KETOTIC%SMPDB%SMP0000485 Hyperglycinemia, Non-Ketotic 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 CORTICOSTERONE METHYL OXIDASE I DEFICIENCY (CMO I)%PATHWHIZ%PW000553 Corticosterone Methyl Oxidase I Deficiency (CMO I) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 STEROID BIOSYNTHESIS%PATHWHIZ%PW000050 Steroid Biosynthesis 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 VASOPRESSIN REGULATION OF WATER HOMEOSTASIS%PATHWHIZ%PW000447 Vasopressin Regulation of Water Homeostasis 14701 14688 14309 210044 18749 14699 12000 COAGULATION%SMPDB%SMP0000586 Coagulation 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 ACENOCOUMAROL ACTION PATHWAY%PATHWHIZ%PW000312 Acenocoumarol Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 ETHANOL DEGRADATION%PATHWHIZ%PW000021 Ethanol Degradation 68738 12359 60525 72535 11669 13106 MINOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000360 Minocycline Action Pathway STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW088364 Starch and Sucrose Metabolism 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 GLYCEROL KINASE DEFICIENCY%SMPDB%SMP0000187 Glycerol Kinase Deficiency 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 PROTEIN SYNTHESIS: GLYCINE%PATHWHIZ%PW112928 Protein Synthesis: Glycine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 353172 27050 27370 GALACTOSEMIA%PATHWHIZ%PW000200 Galactosemia 11677 72157 74246 14430 226413 216558 12091 14387 11605 15275 14377 14595 BLOCH PATHWAY (CHOLESTEROL BIOSYNTHESIS)%SMPDB%SMP0121057 Bloch Pathway (Cholesterol Biosynthesis) 66234 235293 18194 98386 13121 13360 15490 13595 74754 TYROSINEMIA TYPE 2 (OR RICHNER-HANHART SYNDROME)%SMPDB%SMP0000369 Tyrosinemia Type 2 (or Richner-Hanhart Syndrome) 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 VALDECOXIB ACTION PATHWAY%SMPDB%SMP0000116 Valdecoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 SALICYLATE-SODIUM ACTION PATHWAY%SMPDB%SMP0000708 Salicylate-Sodium Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 DOCETAXEL ACTION PATHWAY%PATHWHIZ%PW000240 Docetaxel Action Pathway 12780 26357 18671 17250 28253 545486 22143 SEPIAPTERIN REDUCTASE DEFICIENCY%PATHWHIZ%PW000467 Sepiapterin Reductase Deficiency 110391 20751 13361 11677 12408 19286 320415 14528 HYPER-IGD SYNDROME%SMPDB%SMP0000509 Hyper-IgD Syndrome 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 TRIPROLIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057581 Triprolidine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CORTICOSTERONE METHYL OXIDASE II DEFICIENCY (CMO II)%SMPDB%SMP0000578 Corticosterone Methyl Oxidase II Deficiency (CMO II) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 NAD+ SIGNALLING PATHWAY (CANCER)%PATHWHIZ%PW084315 NAD+ Signalling Pathway (Cancer) 192185 226518 93759 59027 66454 12494 71361 18104 74080 22059 OLMESARTAN ACTION PATHWAY%SMPDB%SMP0000163 Olmesartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 GLUTAMINOLYSIS AND CANCER%SMPDB%SMP0002298 Glutaminolysis and Cancer 55951 216456 20540 209837 56309 16828 17436 269951 55963 104112 20514 66945 18563 14719 67834 56451 66925 20501 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 67680 66052 12974 14661 PHOTOSYNTHESIS%SMPDB%SMP0012089 Photosynthesis 19895 21991 66646 KIDNEY FUNCTION - ASCENDING LIMB OF THE LOOP OF HENLE%PATHWHIZ%PW122277 Kidney Function - Ascending Limb of The Loop of Henle 11931 20495 11932 56365 11933 100038824 11928 98660 232975 107723 FRUCTOSE METABOLISM%PATHWHIZ%PW122616 Fructose Metabolism AMILORIDE ACTION PATHWAY%SMPDB%SMP0000133 Amiloride Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 METHOTREXATE ACTION PATHWAY%SMPDB%SMP0000432 Methotrexate Action Pathway 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%PATHWHIZ%PW000529 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 SALICYLIC ACID ACTION PATHWAY%SMPDB%SMP0000709 Salicylic Acid Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 CITRULLINEMIA TYPE I%PATHWHIZ%PW000185 Citrullinemia Type I 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 AZELASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060741 Azelastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PROMETHAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060150 Promethazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 METHYLENETETRAHYDROFOLATE REDUCTASE DEFICIENCY (MTHFRD)%SMPDB%SMP0000340 Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 RABEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000592 Rabeprazole Metabolism Pathway 11944 11945 DIMETHYLTHIAMBUTENE ACTION PATHWAY%SMPDB%SMP0000680 Dimethylthiambutene Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 RABEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000319 Rabeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 AMINOCAPROIC ACID ACTION PATHWAY%PATHWHIZ%PW000308 Aminocaproic Acid Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 ETODOLAC ACTION PATHWAY%PATHWHIZ%PW000129 Etodolac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PROTEIN SYNTHESIS: PROLINE%PATHWHIZ%PW113695 Protein Synthesis: Proline 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 107508 22121 65019 27050 27370 OXYBUPROCAINE ACTION PATHWAY%SMPDB%SMP0000400 Oxybuprocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 VERAPAMIL ACTION PATHWAY%SMPDB%SMP0000375 Verapamil Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 TYROSINE HYDROXYLASE DEFICIENCY%SMPDB%SMP0000497 Tyrosine Hydroxylase Deficiency 21823 18948 13195 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW122101 Sucrase-Isomaltase Deficiency 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 ORNITHINE AMINOTRANSFERASE DEFICIENCY (OAT DEFICIENCY)%SMPDB%SMP0000363 Ornithine Aminotransferase Deficiency (OAT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 CXCR4 SIGNALING PATHWAY%SMPDB%SMP0064625 CXCR4 Signaling Pathway 14688 19229 12927 18705 18803 20315 12767 14677 14699 26413 110157 15461 18033 18035 12928 26395 26417 19303 14682 14083 ARGININE: GLYCINE AMIDINOTRANSFERASE DEFICIENCY (AGAT DEFICIENCY)%PATHWHIZ%PW000084 Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 SHORT-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (SCAD DEFICIENCY)%PATHWHIZ%PW000108 Short-Chain Acyl-CoA Dehydrogenase Deficiency (SCAD Deficiency) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0120839 Mucopolysaccharidosis VII. Sly Syndrome 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 SPIRAPRIL METABOLISM PATHWAY%SMPDB%SMP0000598 Spirapril Metabolism Pathway 11421 FORASARTAN ACTION PATHWAY%PATHWHIZ%PW000280 Forasartan Action Pathway 11607 100038824 11606 11421 DICOUMAROL ACTION PATHWAY%PATHWHIZ%PW000632 Dicoumarol Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 CITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000426 Citalopram Action Pathway 20266 11931 15550 11932 11549 107141 17161 109731 18549 11933 20264 11928 98660 13113 56808 12295 56448 11761 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 TRIPELENNAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0057587 Tripelennamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THENYLDIAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062624 Thenyldiamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 2-HYDROXYGLUTRIC ACIDURIA (D AND L FORM)%SMPDB%SMP0000136 2-Hydroxyglutric Aciduria (D and L Form) 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 WOLMAN DISEASE%PATHWHIZ%PW000487 Wolman Disease 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 FRUCTOSE INTOLERANCE, HEREDITARY%PATHWHIZ%PW121913 Fructose Intolerance, Hereditary 18642 14120 21991 15275 230163 11676 LIDOCAINE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000381 Lidocaine (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 13077 13114 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 OXPRENOLOL ACTION PATHWAY%PATHWHIZ%PW000372 Oxprenolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BLUE DIAPER SYNDROME%SMPDB%SMP0000583 Blue Diaper Syndrome 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE II%PATHWHIZ%PW000192 Congenital Bile Acid Synthesis Defect Type II 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 CANDESARTAN ACTION PATHWAY%SMPDB%SMP0000158 Candesartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 LACTIC ACIDEMIA%PATHWHIZ%PW000114 Lactic Acidemia 76282 11611 55951 18563 224805 TNF STRESS RELATED SIGNALING%PATHWHIZ%PW064784 TNF Stress Related Signaling 19766 21353 12366 26397 12905 71609 22030 21926 26412 100040260 26399 26419 26398 12675 26416 26401 16476 18033 26400 18035 16151 16150 TRIAMTERENE ACTION PATHWAY%SMPDB%SMP0000132 Triamterene Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 POLYTHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000326 Polythiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 PHYTANIC ACID PEROXISOMAL OXIDATION%PATHWHIZ%PW000041 Phytanic Acid Peroxisomal Oxidation 16922 11671 26874 11666 26458 56794 LEPIRUDIN ACTION PATHWAY%SMPDB%SMP0000278 Lepirudin Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 PHOSPHOLIPASE C SIGNALING PATHWAY%PATHWHIZ%PW109280 Phospholipase C Signaling Pathway 18750 18795 18803 11651 104709 MUCOPOLYSACCHARIDOSIS VII. SLY SYNDROME%SMPDB%SMP0000556 Mucopolysaccharidosis VII. Sly Syndrome 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 CYSTINURIA%PATHWHIZ%PW000700 Cystinuria 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 MITOCHONDRIAL BETA-OXIDATION OF LONG CHAIN SATURATED FATTY ACIDS%SMPDB%SMP0000482 Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids 15107 52538 93747 231086 97212 11363 14081 57279 12894 12896 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088427 Inositol Phosphate Metabolism 76500 228550 71207 69718 327655 16329 71780 55980 269180 2-METHYL-3-HYDROXYBUTYRYL-COA DEHYDROGENASE DEFICIENCY%PATHWHIZ%PW000061 2-Methyl-3-hydroxybutyryl-CoA Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GLUCONEOGENESIS%PATHWHIZ%PW088242 Gluconeogenesis 18563 55951 12183 21991 100043349 14377 13806 230163 56012 319625 20526 67863 14751 14121 211347 18648 72157 18534 PYRIDOXINE DEPENDENCY WITH SEIZURES%SMPDB%SMP0000571 Pyridoxine Dependency with Seizures 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 PYRROBUTAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062887 Pyrrobutamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 OXYCODONE ACTION PATHWAY%SMPDB%SMP0000409 Oxycodone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 DOXYCYCLINE ACTION PATHWAY%PATHWHIZ%PW000359 Doxycycline Action Pathway ACEBUTOLOL ACTION PATHWAY%SMPDB%SMP0000296 Acebutolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 CARBINOXAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058797 Carbinoxamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 AMIKACIN ACTION PATHWAY%SMPDB%SMP0000253 Amikacin Action Pathway NICOTINE ACTION PATHWAY%SMPDB%SMP0000431 Nicotine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 13087 11928 394433 13088 98660 394434 110834 56808 12295 14262 11761 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HEREDITARY COPROPORPHYRIA (HCP)%SMPDB%SMP0000342 Hereditary Coproporphyria (HCP) 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%SMPDB%SMP0120488 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 GLOBOID CELL LEUKODYSTROPHY%PATHWHIZ%PW000202 Globoid Cell Leukodystrophy 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 LEVOBUPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000403 Levobupivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 HISTIDINE METABOLISM%SMPDB%SMP0000044 Histidine Metabolism 14317 11670 17161 76507 15186 243537 140483 66054 67383 70791 71974 15109 11669 15115 71761 107239 338403 PROTEIN SYNTHESIS: ISOLEUCINE%SMPDB%SMP0111872 Protein Synthesis: Isoleucine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 105148 27370 MALATE-ASPARTATE SHUTTLE%PATHWHIZ%PW000030 Malate-Aspartate Shuttle 14719 78830 17448 67863 UMP SYNTHASE DEFICIENCY (OROTIC ACIDURIA)%SMPDB%SMP0000219 UMP Synthase Deficiency (Orotic Aciduria) 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 SARCOSINE ONCOMETABOLITE PATHWAY%SMPDB%SMP0002313 Sarcosine Oncometabolite Pathway 238505 108645 74129 110695 232087 14711 20425 12116 192166 218865 108037 68682 100434 PROCAINAMIDE (ANTIARRHYTHMIC) ACTION PATHWAY%PATHWHIZ%PW000377 Procainamide (Antiarrhythmic) Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 BISOPROLOL ACTION PATHWAY%SMPDB%SMP0000300 Bisoprolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 COCAINE ACTION PATHWAY%SMPDB%SMP0000395 Cocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 DIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058785 Diphenhydramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LECTIN-INDUCED COMPLEMENT PATHWAY%SMPDB%SMP0063898 Lectin-Induced Complement Pathway 109828 625018 12263 230558 17195 12279 17175 15139 12266 12274 FATTY ACID BIOSYNTHESIS%SMPDB%SMP0000456 Fatty Acid Biosynthesis 14104 107476 CAPECITABINE ACTION PATHWAY%PATHWHIZ%PW000256 Capecitabine Action Pathway 434203 104158 72269 72962 22171 L-ARGININE:GLYCINE AMIDINOTRANSFERASE DEFICIENCY%PATHWHIZ%PW000483 L-Arginine:Glycine Amidinotransferase Deficiency 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 PROTEIN SYNTHESIS: ARGININE%SMPDB%SMP0111853 Protein Synthesis: Arginine 20115 104458 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 BETA-ALANINE METABOLISM%SMPDB%SMP0000007 beta-Alanine Metabolism 14415 268860 104776 11669 64705 99586 11754 103149 338403 TENIPOSIDE ACTION PATHWAY%SMPDB%SMP0000443 Teniposide Action Pathway 17523 13114 21973 TRANSFER OF ACETYL GROUPS INTO MITOCHONDRIA%SMPDB%SMP0000466 Transfer of Acetyl Groups into Mitochondria 17449 17436 104112 55951 18563 68263 67863 18597 CLOPIDOGREL METABOLISM PATHWAY%PATHWHIZ%PW000586 Clopidogrel Metabolism Pathway 107141 18979 70839 13077 13114 13088 18671 CLOMOCYCLINE ACTION PATHWAY%SMPDB%SMP0000262 Clomocycline Action Pathway GLICLAZIDE ACTION PATHWAY%SMPDB%SMP0000461 Gliclazide Action Pathway 20927 16334 12286 20526 56808 12295 GLYCEROL METABOLISM%SMPDB%SMP0121309 Glycerol Metabolism 4-HYDROXYBUTYRIC ACIDURIA SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000243 4-Hydroxybutyric Aciduria Succinic Semialdehyde Dehydrogenase Deficiency 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 ALENDRONATE ACTION PATHWAY%PATHWHIZ%PW000137 Alendronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 LABETALOL ACTION PATHWAY%PATHWHIZ%PW000389 Labetalol Action Pathway 20648 11931 11932 11549 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 LONG-CHAIN-3-HYDROXYACYL-COA DEHYDROGENASE DEFICIENCY (LCHAD)%PATHWHIZ%PW000520 Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase Deficiency (LCHAD) 15108 52538 93747 26922 231086 97212 19063 THONZYLAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059696 Thonzylamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 BETA-UREIDOPROPIONASE DEFICIENCY%PATHWHIZ%PW000187 beta-Ureidopropionase Deficiency 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0000358 Fc Epsilon Receptor I Signaling in Mast Cells 18750 16331 18803 14125 16822 16163 16191 16189 16653 20963 19353 228026 18783 14784 18706 17096 18176 16797 12981 14127 57257 26419 14126 26398 110157 26416 15461 11651 18708 26400 14360 26395 26396 26397 26413 12229 21926 26399 20662 14389 DOXEPIN H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060816 Doxepin H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PROPIOMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063580 Propiomazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 STEROIDOGENESIS%SMPDB%SMP0000130 Steroidogenesis 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 GASTRIC ACID PRODUCTION%SMPDB%SMP0000589 Gastric Acid Production 20608 12346 15466 11944 11945 20604 14459 12426 12671 FLECAINIDE ACTION PATHWAY%SMPDB%SMP0000331 Flecainide Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 S-ADENOSYLHOMOCYSTEINE (SAH) HYDROLASE DEFICIENCY%PATHWHIZ%PW000102 S-Adenosylhomocysteine (SAH) Hydrolase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 GOUT OR KELLEY-SEEGMILLER SYNDROME%SMPDB%SMP0000365 Gout or Kelley-Seegmiller Syndrome 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW064563 Pentose Phosphate Pathway 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 THE ONCOGENIC ACTION OF L-2-HYDROXYGLUTARATE IN HYDROXYGLUTARIC ACIDURIA%PATHWHIZ%PW002451 The Oncogenic Action of L-2-Hydroxyglutarate in Hydroxyglutaric aciduria 55951 217666 216456 269951 66945 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 14661 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0087400 Pentose Phosphate Pathway 74419 66171 56421 14121 14751 14381 110639 19895 72157 71336 21351 66646 232449 SUCCINATE SIGNALLING DURING INFLAMMATION%PATHWHIZ%PW122149 Succinate Signalling During Inflammation 18127 18750 18795 12912 18033 26413 16151 16150 26417 METHIONINE METABOLISM%SMPDB%SMP0000033 Methionine Metabolism 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 PANITUMUMAB ACTION PATHWAY%SMPDB%SMP0000475 Panitumumab Action Pathway 13649 THIAZINAMIUM H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061692 Thiazinamium H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MULTIPLE CARBOXYLASE DEFICIENCY, NEONATAL OR EARLY ONSET FORM%SMPDB%SMP0000564 Multiple Carboxylase Deficiency, Neonatal or Early Onset Form 69019 110948 100705 26363 LANSOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000590 Lansoprazole Metabolism Pathway 11944 11945 NETILMICIN ACTION PATHWAY%SMPDB%SMP0000257 Netilmicin Action Pathway HYPOACETYLASPARTIA%PATHWHIZ%PW000094 Hypoacetylaspartia 27053 69719 11898 109900 14415 268860 11565 14204 11484 70503 70223 226414 11564 66514 ISOVALERIC ACIDURIA%PATHWHIZ%PW000091 Isovaleric Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 11-BETA-HYDROXYLASE DEFICIENCY (CYP11B1)%SMPDB%SMP0000575 11-beta-Hydroxylase Deficiency (CYP11B1) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 DOBUTAMINE ACTION PATHWAY%PATHWHIZ%PW000639 Dobutamine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 NABUMETONE ACTION PATHWAY%SMPDB%SMP0000114 Nabumetone Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 3-PHOSPHOGLYCERATE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000721 3-Phosphoglycerate Dehydrogenase Deficiency 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 ANTRAFENINE ACTION PATHWAY%SMPDB%SMP0000693 Antrafenine Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 TAURINE AND HYPOTAURINE METABOLISM%SMPDB%SMP0000021 Taurine and Hypotaurine Metabolism 71522 14415 211488 246277 12583 SMITH-LEMLI-OPITZ SYNDROME (SLOS)%PATHWHIZ%PW000095 Smith-Lemli-Opitz Syndrome (SLOS) 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 CONGENITAL BILE ACID SYNTHESIS DEFECT TYPE III%PATHWHIZ%PW000193 Congenital Bile Acid Synthesis Defect Type III 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 DIPYRIDAMOLE (ANTIPLATELET) ACTION PATHWAY%SMPDB%SMP0000264 Dipyridamole (Antiplatelet) Action Pathway 238871 HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA [HHH-SYNDROME]%PATHWHIZ%PW000482 Hyperornithinemia-Hyperammonemia-Homocitrullinuria [HHH-syndrome] 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 GEFITINIB ACTION PATHWAY%SMPDB%SMP0000473 Gefitinib Action Pathway 13649 THIOGUANINE ACTION PATHWAY%PATHWHIZ%PW000429 Thioguanine Action Pathway 63959 15452 19353 75456 27416 239273 11564 16434 11486 23984 67054 67979 11636 229363 210044 13340 14450 269346 54369 22017 76952 11534 238871 53893 231327 11761 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 114304 PHENBENZAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060645 Phenbenzamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PRILOCAINE ACTION PATHWAY%PATHWHIZ%PW000407 Prilocaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 NITRENDIPINE ACTION PATHWAY%SMPDB%SMP0000382 Nitrendipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW122064 Ribose-5-phosphate Isomerase Deficiency 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 QUINIDINE ACTION PATHWAY%SMPDB%SMP0000323 Quinidine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PHENINDIONE ACTION PATHWAY%SMPDB%SMP0000655 Phenindione Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 TICLOPIDINE METABOLISM PATHWAY%SMPDB%SMP0000611 Ticlopidine Metabolism Pathway 70839 BTG FAMILY PROTEINS AND CELL CYCLE REGULATION%SMPDB%SMP0063773 BTG Family Proteins and Cell Cycle Regulation 19645 15469 27221 18049 15417 12226 14164 12227 12443 22059 TRANEXAMIC ACID ACTION PATHWAY%PATHWHIZ%PW000309 Tranexamic Acid Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 GLIBENCLAMIDE ACTION PATHWAY%SMPDB%SMP0000460 Glibenclamide Action Pathway 20927 16334 12286 20526 56808 12295 ION CHANNELS AND THEIR FUNCTIONAL ROLE IN VASCULAR ENDOTHELIUM%SMPDB%SMP0063778 Ion Channels and Their Functional Role in Vascular Endothelium 63873 60613 226922 26946 60596 16536 110862 271639 54195 18127 234889 19091 19092 22065 22066 DOXEPIN METABOLISM PATHWAY%PATHWHIZ%PW000617 Doxepin Metabolism Pathway 107141 13077 13114 56448 TELMISARTAN ACTION PATHWAY%PATHWHIZ%PW000284 Telmisartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 ESMOLOL ACTION PATHWAY%SMPDB%SMP0000301 Esmolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY%SMPDB%SMP0000210 Purine Nucleoside Phosphorylase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 LAMIVUDINE METABOLISM PATHWAY%PATHWHIZ%PW000625 Lamivudine Metabolism Pathway 13178 13026 20887 18102 50773 26357 20519 212862 18671 17250 66588 76408 20517 12780 18655 68671 20518 239273 VENLAFAXINE METABOLISM PATHWAY%PATHWHIZ%PW000612 Venlafaxine Metabolism Pathway 107141 20538 13114 56448 15567 18671 GALACTOSEMIA II (GALK)%SMPDB%SMP0000495 Galactosemia II (GALK) 72157 74246 67883 14430 216558 22235 103988 14635 ROSIGLITAZONE METABOLISM PATHWAY%PATHWHIZ%PW000629 Rosiglitazone Metabolism Pathway 72303 EPLERENONE ACTION PATHWAY%SMPDB%SMP0000135 Eplerenone Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 ETOPOSIDE METABOLISM PATHWAY%PATHWHIZ%PW000577 Etoposide Metabolism Pathway 13114 21974 71853 69191 18671 67838 12304 394436 19035 64136 12282 76408 67397 14828 19224 17523 19225 21973 OMEPRAZOLE METABOLISM PATHWAY%SMPDB%SMP0000613 Omeprazole Metabolism Pathway 11944 11945 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW121877 Sucrase-Isomaltase Deficiency 110006 22239 15275 14751 ARBUTAMINE ACTION PATHWAY%SMPDB%SMP0000664 Arbutamine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 METHADYL ACETATE ACTION PATHWAY%PATHWHIZ%PW000655 Methadyl Acetate Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MAPLE SYRUP URINE DISEASE%PATHWHIZ%PW000064 Maple Syrup Urine Disease 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 HOMOCARNOSINOSIS%SMPDB%SMP0000385 Homocarnosinosis 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 ARSENATE DETOXIFICATION%PATHWHIZ%PW122396 Arsenate Detoxification 18950 11832 64008 14873 57344 20528 20525 TYROSINEMIA TYPE 3 (TYRO3)%PATHWHIZ%PW000121 Tyrosinemia Type 3 (TYRO3) 107271 14204 14718 234724 14085 15445 14874 23874 66590 15233 18478 HISTAMINE H1 RECEPTOR ACTIVATION%SMPDB%SMP0063452 Histamine H1 Receptor Activation 14688 18795 18751 18033 16438 15465 14702 14682 INOSITOL PHOSPHATE METABOLISM%PATHWHIZ%PW088275 Inositol Phosphate Metabolism 228550 327655 16329 71780 55980 234515 217837 17330 56409 27399 PROTEIN SYNTHESIS: SERINE%PATHWHIZ%PW120517 Protein Synthesis: Serine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 20226 LYSOPHOSPHATIDIC ACID LPA2 SIGNALLING%SMPDB%SMP0063753 Lysophosphatidic Acid LPA2 Signalling 14688 18795 11651 19877 432530 20807 16438 53978 14702 BILE ACID INDIRECT SIGNALLING PATHWAY%SMPDB%SMP0086851 Bile Acid Indirect Signalling Pathway 20186 14170 83379 14186 14183 14184 20494 14182 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120596 Glycogenosis, Type VII. Tarui Disease 18663 68401 12183 21991 15275 230163 13806 319625 56421 14751 14447 18746 239606 18648 PANCREAS FUNCTION - ALPHA CELL%PATHWHIZ%PW122296 Pancreas Function - Alpha Cell 20648 20927 20271 14526 20650 12286 20526 56808 20649 12295 FLUNARIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0061047 Flunarizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 CARPROFEN ACTION PATHWAY%SMPDB%SMP0000694 Carprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PHENPROCOUMON ACTION PATHWAY%PATHWHIZ%PW000314 Phenprocoumon Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 FRUCTOSURIA%SMPDB%SMP0000561 Fructosuria 234730 75454 22122 21991 75540 331026 15275 230163 11674 14121 18641 20322 11677 16548 218138 29858 18639 110119 BETA OXIDATION OF VERY LONG CHAIN FATTY ACIDS%PATHWHIZ%PW000161 Beta Oxidation of Very Long Chain Fatty Acids 69129 26874 14081 57279 11666 74114 12908 12896 72129 56273 INTRACELLULAR SIGNALLING THROUGH PROSTACYCLIN RECEPTOR AND PROSTACYCLIN%SMPDB%SMP0000354 Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin 14688 210044 18749 19222 14699 17897 107589 CHLORPHENAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW057579 Chlorphenamine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 LYSINE DEGRADATION%PATHWHIZ%PW000029 Lysine Degradation 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 TOLL-LIKE RECEPTOR PATHWAY 2%SMPDB%SMP0069593 Toll-Like Receptor Pathway 2 26940 81897 53791 21899 66724 21897 170744 26409 26419 26398 12675 12475 117149 26416 17087 26401 21898 22034 18033 17874 18035 16151 16150 19697 54473 170743 16179 66513 142980 24088 68652 GUANIDINOACETATE METHYLTRANSFERASE DEFICIENCY (GAMT DEFICIENCY)%SMPDB%SMP0000188 Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 IRINOTECAN METABOLISM PATHWAY%SMPDB%SMP0000600 Irinotecan Metabolism Pathway 104158 12038 21969 13114 436059 26357 71853 69191 18671 67838 17250 394434 12304 394436 19035 64136 12282 67397 14828 12780 RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0120584 Ribose-5-phosphate Isomerase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 QUIFENADINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061693 Quifenadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYDROCODONE ACTION PATHWAY%SMPDB%SMP0000411 Hydrocodone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PANTOTHENATE AND COA BIOSYNTHESIS%SMPDB%SMP0000027 Pantothenate and CoA Biosynthesis 18605 22361 71743 106564 75735 66812 METOPROLOL ACTION PATHWAY%PATHWHIZ%PW000370 Metoprolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PENTOSE PHOSPHATE PATHWAY%SMPDB%SMP0000031 Pentose Phosphate Pathway 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 TRIFUNCTIONAL PROTEIN DEFICIENCY%SMPDB%SMP0000545 Trifunctional Protein Deficiency 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 MOLYBDENUM COFACTOR DEFICIENCY%SMPDB%SMP0000203 Molybdenum Cofactor Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 SOTALOL ACTION PATHWAY%SMPDB%SMP0000660 Sotalol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 NON-KETOTIC HYPERGLYCINEMIA%PATHWHIZ%PW000209 Non-Ketotic Hyperglycinemia 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 MOEXIPRIL ACTION PATHWAY%SMPDB%SMP0000151 Moexipril Action Pathway 100038824 11606 11421 17-ALPHA-HYDROXYLASE DEFICIENCY (CYP17)%PATHWHIZ%PW000542 17-alpha-Hydroxylase Deficiency (CYP17) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 LEVOCETIRIZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060053 Levocetirizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TEMELASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW063837 Temelastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2A AND ADENOSINE%SMPDB%SMP0000320 Intracellular Signalling Through Adenosine Receptor A2a and Adenosine 14688 18479 109905 11909 19094 18706 26407 18034 54126 109880 26419 11540 12675 223864 13712 56513 15461 76089 11651 26401 16476 18762 18033 26400 18035 16150 26396 18607 18749 12912 14699 26413 20111 26399 12015 ACTIVATION OF PKC THROUGH G PROTEIN-COUPLED RECEPTOR%PATHWHIZ%PW000726 Activation of PKC Through G Protein-Coupled Receptor 18750 18795 16438 14682 HAWKINSINURIA%PATHWHIZ%PW000181 Hawkinsinuria 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 FOLATE MALABSORPTION, HEREDITARY%PATHWHIZ%PW000701 Folate Malabsorption, Hereditary 107747 14317 13361 17768 100039707 270685 14287 52466 17769 69606 108156 667301 SUFENTANIL ACTION PATHWAY%PATHWHIZ%PW000423 Sufentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CLOCINIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062788 Clocinizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PROPANOATE METABOLISM%SMPDB%SMP0000016 Propanoate Metabolism 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 TRICHLORMETHIAZIDE ACTION PATHWAY%SMPDB%SMP0000121 Trichlormethiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 FATTY ACID ELONGATION IN MITOCHONDRIA%SMPDB%SMP0000054 Fatty Acid Elongation in Mitochondria 15108 52538 93747 26922 231086 97212 19063 ALVIMOPAN ACTION PATHWAY%SMPDB%SMP0000685 Alvimopan Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROTEIN SYNTHESIS: THREONINE%PATHWHIZ%PW120525 Protein Synthesis: Threonine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 110960 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 SIMVASTATIN ACTION PATHWAY%PATHWHIZ%PW000127 Simvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%PATHWHIZ%PW121882 Fructose-1,6-diphosphatase Deficiency 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 WARBURG EFFECT%PATHWHIZ%PW088382 Warburg Effect 55951 100043349 13806 56012 18655 20512 18770 66945 67834 66925 56451 209692 20501 11429 14194 13382 235339 21881 68263 170718 15926 11428 78920 14751 14381 17449 18641 18746 67680 66052 12974 19895 14661 14660 15277 21351 PTERINE BIOSYNTHESIS%PATHWHIZ%PW000140 Pterine Biosynthesis 110391 20751 13361 11677 12408 19286 320415 14528 NUCLEOTIDE SUGARS METABOLISM%PATHWHIZ%PW000031 Nucleotide Sugars Metabolism 72157 74246 67883 14430 216558 22235 103988 14635 PYRUVATE DEHYDROGENASE DEFICIENCY (E3)%SMPDB%SMP0000550 Pyruvate Dehydrogenase Deficiency (E3) 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 3-METHYLTHIOFENTANYL ACTION PATHWAY%PATHWHIZ%PW000656 3-Methylthiofentanyl Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROTEIN SYNTHESIS: ALANINE%PATHWHIZ%PW120529 Protein Synthesis: Alanine 20115 319195 67248 100043391 100040331 432502 667279 668144 100043755 621100 665189 67281 666899 100042670 629957 100039316 76846 667739 234734 100038875 19921 100038991 267019 100043876 100043000 100043423 16785 100042986 20044 100040298 20088 100042740 56040 667618 57294 666669 100040970 20085 20084 19899 67891 66480 67097 19934 66481 67025 100039924 19941 100042823 14694 100039656 20055 672959 20054 666586 676253 67427 670211 100043527 27207 666487 68193 67186 19989 19951 76808 75617 20103 20102 20068 22121 65019 26961 27050 27370 VINBLASTINE ACTION PATHWAY%SMPDB%SMP0000436 Vinblastine Action Pathway 224814 76408 12575 12780 13114 18671 17250 545486 19765 22143 22059 QUINAPRIL METABOLISM PATHWAY%SMPDB%SMP0000596 Quinapril Metabolism Pathway 11421 CARVEDILOL ACTION PATHWAY%SMPDB%SMP0000367 Carvedilol Action Pathway 20648 11931 11932 11549 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 TRANDOLAPRIL ACTION PATHWAY%SMPDB%SMP0000157 Trandolapril Action Pathway 100038824 11606 11421 BETAHISTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061694 Betahistine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 DEMECLOCYCLINE ACTION PATHWAY%PATHWHIZ%PW000358 Demeclocycline Action Pathway INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0063630 Inositol Phosphate Metabolism 69718 102954 16332 277360 ESOMEPRAZOLE ACTION PATHWAY%PATHWHIZ%PW000315 Esomeprazole Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 SARCOSINEMIA%SMPDB%SMP0000244 Sarcosinemia 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 LYSINURIC PROTEIN INTOLERANCE (LPI)%SMPDB%SMP0000585 Lysinuric Protein Intolerance (LPI) 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 QUETIAPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062884 Quetiapine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 UBIQUINONE BIOSYNTHESIS%SMPDB%SMP0000065 Ubiquinone Biosynthesis 12850 71883 217707 52064 230027 EPINASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW062142 Epinastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 GLYCOGENOSIS, TYPE IA. VON GIERKE DISEASE%SMPDB%SMP0120864 Glycogenosis, Type IA. Von Gierke Disease 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 XANTHINE DEHYDROGENASE DEFICIENCY (XANTHINURIA)%SMPDB%SMP0000220 Xanthine Dehydrogenase Deficiency (Xanthinuria) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW122117 Glycogenosis, Type IB 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120838 Glycogenosis, Type VI. Hers Disease 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 AZITHROMYCIN ACTION PATHWAY%PATHWHIZ%PW000345 Azithromycin Action Pathway PYRUVATE DEHYDROGENASE DEFICIENCY (E2)%SMPDB%SMP0000551 Pyruvate Dehydrogenase Deficiency (E2) 66945 55951 18563 67834 56451 66925 209692 20917 11429 13382 14194 235339 68263 170718 18597 15929 78920 17449 67680 66052 12974 TRISALICYLATE-CHOLINE ACTION PATHWAY%PATHWHIZ%PW000680 Trisalicylate-Choline Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 HISTIDINEMIA%PATHWHIZ%PW000113 Histidinemia 14317 11670 17161 76507 15186 243537 140483 66054 67383 70791 71974 15109 11669 15115 71761 107239 338403 CILOSTAZOL ACTION PATHWAY%SMPDB%SMP0000263 Cilostazol Action Pathway 107141 13114 238871 MONOAMINE OXIDASE-A DEFICIENCY (MAO-A)%PATHWHIZ%PW000509 Monoamine Oxidase-A Deficiency (MAO-A) 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 FENETHAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059707 Fenethazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MITOCHONDRIAL BETA-OXIDATION OF MEDIUM CHAIN SATURATED FATTY ACIDS%PATHWHIZ%PW000172 Mitochondrial Beta-Oxidation of Medium Chain Saturated Fatty Acids 15107 52538 93747 231086 97212 117147 57279 11364 ROXITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000251 Roxithromycin Action Pathway SULFATE SULFITE METABOLISM%PATHWHIZ%PW000040 Sulfate Sulfite Metabolism 58250 54200 20887 23827 211389 23972 ANDROSTENEDIONE METABOLISM%SMPDB%SMP0030406 Androstenedione Metabolism 110115 15483 71853 69191 67838 12304 78925 208665 394436 15487 83702 19035 64136 13075 12282 67397 14828 CYCLOPHOSPHAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000580 Cyclophosphamide Metabolism Pathway 11670 107141 11668 14863 13114 13088 13087 72303 THE ONCOGENIC ACTION OF SUCCINATE%PATHWHIZ%PW002360 The Oncogenic Action of Succinate 55951 269951 112407 112406 66945 18563 67834 27376 56451 66925 209692 20917 11429 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 BEVACIZUMAB ACTION PATHWAY%SMPDB%SMP0000420 Bevacizumab Action Pathway 16542 22339 14254 NEOMYCIN ACTION PATHWAY%SMPDB%SMP0000256 Neomycin Action Pathway MORPHINE METABOLISM PATHWAY%SMPDB%SMP0000622 Morphine Metabolism Pathway 22236 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 71773 231396 18390 GLYCEROL METABOLISM III (SN-GLYCERO-3-PHOSPHOETHANOLAMINE)%PATHWHIZ%PW000916 Glycerol Metabolism III (sn-Glycero-3-Phosphoethanolamine) BROMODIPHENHYDRAMINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059740 Bromodiphenhydramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TRANSALDOLASE DEFICIENCY%SMPDB%SMP0120585 Transaldolase Deficiency 230163 14751 18642 19895 67763 71336 14120 100198 21351 66646 110208 232449 83553 KETOPROFEN ACTION PATHWAY%SMPDB%SMP0000085 Ketoprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 LIDOCAINE (LOCAL ANAESTHETIC) ACTION PATHWAY%SMPDB%SMP0000398 Lidocaine (Local Anaesthetic) Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 13077 13114 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS%SMPDB%SMP0029731 Phosphatidylethanolamine Biosynthesis 12660 19210 68671 320951 99712 METHYLMALONIC ACIDURIA%SMPDB%SMP0000200 Methylmalonic Aciduria 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 PROTEIN SYNTHESIS: TYROSINE%PATHWHIZ%PW120527 Protein Synthesis: Tyrosine 20115 319195 67248 107271 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 BETA-KETOTHIOLASE DEFICIENCY%SMPDB%SMP0000173 beta-Ketothiolase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 GLYCOLYSIS%SMPDB%SMP0063478 Glycolysis 18663 68401 12183 21991 15275 230163 13806 319625 56421 14751 14447 18746 239606 18648 LORNOXICAM ACTION PATHWAY%PATHWHIZ%PW000677 Lornoxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 INOSITOL METABOLISM%SMPDB%SMP0000011 Inositol Metabolism 224020 103199 228550 56208 18711 225326 16329 71780 55980 228361 66461 72469 56727 217837 75678 234729 269180 75669 17330 18706 69718 PROPARACAINE ACTION PATHWAY%PATHWHIZ%PW000409 Proparacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 FLAVONOID BIOSYNTHESIS%SMPDB%SMP0012021 Flavonoid Biosynthesis 71519 ROPIVACAINE ACTION PATHWAY%PATHWHIZ%PW000410 Ropivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 XANTHINURIA TYPE II%PATHWHIZ%PW000489 Xanthinuria Type II 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 VALPROIC ACID METABOLISM PATHWAY%SMPDB%SMP0000635 Valproic Acid Metabolism Pathway 15108 22236 231086 97212 13088 13087 66885 117147 74147 56357 PROTEIN SYNTHESIS: ASPARTIC ACID%SMPDB%SMP0111858 Protein Synthesis: Aspartic Acid 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 226414 27050 27370 LACTOSE INTOLERANCE%PATHWHIZ%PW000206 Lactose Intolerance 20537 11931 11932 11933 11928 226413 98660 20526 232975 CILAZAPRIL ACTION PATHWAY%SMPDB%SMP0000147 Cilazapril Action Pathway 100038824 11606 11421 METIPRANOLOL ACTION PATHWAY%PATHWHIZ%PW000644 Metipranolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FOSPHENYTOIN (ANTIARRHYTHMIC) METABOLISM PATHWAY%SMPDB%SMP0000618 Fosphenytoin (Antiarrhythmic) Metabolism Pathway 20648 20271 20650 20649 LEVOCABASTINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060224 Levocabastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TENECTEPLASE ACTION PATHWAY%SMPDB%SMP0000283 Tenecteplase Action Pathway 12842 110135 99571 18791 18815 14161 14068 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 3-HYDROXYISOBUTYRIC ACID DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000521 3-Hydroxyisobutyric Acid Dehydrogenase Deficiency 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 NEVIRAPINE METABOLISM PATHWAY%PATHWHIZ%PW000618 Nevirapine Metabolism Pathway 224814 11668 13114 13088 56448 394434 DEXCHLORPHENIRAMINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0056811 Dexchlorpheniramine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 G-SECRETASE MEDIATED ERBB4 SIGNALLING PATHWAY%PATHWHIZ%PW090995 g-Secretase Mediated ErbB4 Signalling Pathway 13867 18750 11491 19164 13649 100042150 13869 RAC 1 CELL MOTILITY SIGNALING PATHWAY%SMPDB%SMP0063795 Rac 1 Cell Motility Signaling Pathway 18479 19353 76932 329251 12443 19765 18595 18538 12568 12631 57257 11461 12575 12445 17906 16885 12331 26401 18805 83767 107589 D-ARGININE AND D-ORNITHINE METABOLISM%PATHWHIZ%PW000019 D-Arginine and D-Ornithine Metabolism 13142 TRIOSEPHOSPHATE ISOMERASE DEFICIENCY%PATHWHIZ%PW000539 Triosephosphate Isomerase Deficiency 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 HOMOCYSTEINE DEGRADATION%SMPDB%SMP0000455 Homocysteine Degradation 107869 12411 KETOBEMIDONE ACTION PATHWAY%SMPDB%SMP0000690 Ketobemidone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOLYSIS%PATHWHIZ%PW000146 Glycolysis 12183 14377 100043349 13806 319625 20526 56012 11674 14751 18648 18642 18655 15277 18770 METACHROMATIC LEUKODYSTROPHY (MLD)%SMPDB%SMP0000347 Metachromatic Leukodystrophy (MLD) 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 GLYCOGENOSIS, TYPE III. CORI DISEASE, DEBRANCHER GLYCOGENOSIS%SMPDB%SMP0120617 Glycogenosis, Type III. Cori Disease, Debrancher Glycogenosis 110006 22239 15275 14751 NF-KB SIGNALING PATHWAY%PATHWHIZ%PW064818 NF-kB Signaling Pathway 55984 14082 26409 12675 26401 21898 22034 18033 17874 18035 16151 16150 19697 22190 19766 71609 21926 53859 16177 21937 21938 16179 17979 66513 16175 207565 METHYLHISTIDINE METABOLISM%PATHWHIZ%PW000692 Methylhistidine Metabolism 11461 GLYCINE N-METHYLTRANSFERASE DEFICIENCY%SMPDB%SMP0000222 Glycine N-Methyltransferase Deficiency 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 LONG CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (LCAD)%PATHWHIZ%PW000515 Long Chain Acyl-CoA Dehydrogenase Deficiency (LCAD) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 DEPTROPINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062883 Deptropine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 METHADONE ACTION PATHWAY%PATHWHIZ%PW000414 Methadone Action Pathway 20266 11931 15550 11932 11549 107141 18549 11933 20264 13114 11928 13088 98660 13113 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 72303 16508 18390 232975 14811 14810 13488 BROMFENAC ACTION PATHWAY%SMPDB%SMP0000102 Bromfenac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 ROXATIDINE ACETATE ACTION PATHWAY%PATHWHIZ%PW000711 Roxatidine Acetate Action Pathway 20608 12346 15466 11944 11945 20604 14459 12426 12671 WARBURG EFFECT%SMPDB%SMP0087270 Warburg Effect 55951 100043349 13806 56012 66171 18655 20514 67834 18563 56451 20501 20917 11429 13382 14194 18293 230163 20526 27402 68263 21881 170718 15926 18597 11428 78920 14751 15929 17449 14381 18641 18746 67680 66052 12974 14661 19895 CERIVASTATIN ACTION PATHWAY%PATHWHIZ%PW000271 Cerivastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 OXOMEMAZINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW060682 Oxomemazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 STARCH AND SUCROSE METABOLISM%PATHWHIZ%PW000150 Starch and Sucrose Metabolism 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 PONATINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032598 Ponatinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 ALPHA LINOLENIC ACID AND LINOLEIC ACID METABOLISM%PATHWHIZ%PW000006 Alpha Linolenic Acid and Linoleic Acid Metabolism 83603 68801 56473 76267 OXYMORPHONE ACTION PATHWAY%PATHWHIZ%PW000418 Oxymorphone Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 CARFENTANIL ACTION PATHWAY%SMPDB%SMP0000414 Carfentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GAMMA-GLUTAMYLTRANSFERASE DEFICIENCY%PATHWHIZ%PW000110 gamma-Glutamyltransferase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 KRABBE DISEASE%PATHWHIZ%PW000502 Krabbe Disease 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 PORPHYRIN METABOLISM%SMPDB%SMP0000024 Porphyrin Metabolism 22275 19044 15288 70383 22276 12892 15368 67634 17025 217721 14151 226139 109778 110006 11655 ANDROGEN AND ESTROGEN METABOLISM%SMPDB%SMP0000068 Androgen and Estrogen Metabolism 13075 54200 100559 13074 20860 78925 208665 15497 15487 15485 BETAINE METABOLISM%SMPDB%SMP0000123 Betaine Metabolism 238505 110695 232087 18618 12116 269378 218865 108645 BIOTINIDASE DEFICIENCY%SMPDB%SMP0000174 Biotinidase Deficiency 69019 110948 100705 26363 FUROSEMIDE ACTION PATHWAY%PATHWHIZ%PW000337 Furosemide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 DESLORATADINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0060201 Desloratadine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 ENALAPRIL ACTION PATHWAY%SMPDB%SMP0000148 Enalapril Action Pathway 100038824 11606 11421 ERYTHROMYCIN ACTION PATHWAY%SMPDB%SMP0000250 Erythromycin Action Pathway LEVOMETHADYL ACETATE ACTION ACTION PATHWAY%SMPDB%SMP0000677 Levomethadyl Acetate Action Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 PROTEIN SYNTHESIS: CYSTEINE%PATHWHIZ%PW112918 Protein Synthesis: Cysteine 20115 319195 67248 100043391 27267 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 BAFETINIB INHIBITION OF BCR-ABL%PATHWHIZ%PW032597 Bafetinib Inhibition of BCR-ABL 17869 56717 14784 22059 20662 20850 16452 12576 18708 12048 12929 12928 12015 14389 27401 12402 17246 PYRUVATE CARBOXYLASE DEFICIENCY%SMPDB%SMP0000350 Pyruvate Carboxylase Deficiency 76282 11611 55951 18563 224805 CETUXIMAB ACTION PATHWAY%SMPDB%SMP0000474 Cetuximab Action Pathway 13649 FELODIPINE ACTION PATHWAY%PATHWHIZ%PW000392 Felodipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 MYCOPHENOLIC ACID METABOLISM PATHWAY%PATHWHIZ%PW000628 Mycophenolic Acid Metabolism Pathway 100042069 104158 12780 13114 436059 26357 18671 394434 72303 23917 28253 RETINOL METABOLISM%SMPDB%SMP0000074 Retinol Metabolism 11668 13114 13087 13088 71853 69191 67838 12304 394436 19035 64136 12282 67397 14828 28200 67442 63857 235033 241452 13350 20148 79235 19378 622127 13113 77974 216454 17252 19892 245533 13082 DESIPRAMINE ACTION PATHWAY%PATHWHIZ%PW000425 Desipramine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 DOPAMINE BETA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000498 Dopamine beta-Hydroxylase Deficiency 11670 17161 14718 17319 107766 13166 22173 12846 13190 14085 14874 18948 15233 13195 76507 CLOPIDOGREL ACTION PATHWAY%PATHWHIZ%PW000286 Clopidogrel Action Pathway 107141 18979 70839 13077 13114 13088 18671 TETRACYCLINE ACTION PATHWAY%SMPDB%SMP0000294 Tetracycline Action Pathway EPINEPHRINE ACTION PATHWAY%PATHWHIZ%PW000638 Epinephrine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 3-METHYLGLUTACONIC ACIDURIA TYPE IV%SMPDB%SMP0000141 3-Methylglutaconic Aciduria Type IV 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 THYROID HORMONE SYNTHESIS%PATHWHIZ%PW000693 Thyroid Hormone Synthesis 99439 224480 21819 114479 22018 13058 50490 13057 214593 HYDROXYZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058936 Hydroxyzine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0087197 Fructose and Mannose Degradation 234730 75454 22122 75540 21991 230163 54128 76355 320844 14121 18641 20322 16548 11677 18639 110119 INTRACELLULAR SIGNALLING THROUGH ADENOSINE RECEPTOR A2B AND ADENOSINE%SMPDB%SMP0000321 Intracellular Signalling Through Adenosine Receptor A2b and Adenosine 14688 18479 109905 11909 19094 18706 26407 18034 11541 54126 109880 26419 12675 223864 13712 56513 15461 76089 11651 26401 16476 18762 18033 26400 18035 16150 26396 210044 18607 18749 12912 14699 26413 20111 26399 12015 FANCONI-BICKEL SYNDROME%SMPDB%SMP0000572 Fanconi-Bickel Syndrome 12183 14377 100043349 13806 319625 20526 56012 11674 14751 18648 18642 18655 15277 18770 ROSUVASTATIN ACTION PATHWAY%SMPDB%SMP0000092 Rosuvastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PAROMOMYCIN ACTION PATHWAY%PATHWHIZ%PW000691 Paromomycin Action Pathway PANCREAS FUNCTION - DELTA CELL%PATHWHIZ%PW122406 Pancreas Function - Delta Cell 20927 12286 20604 20526 56808 12295 LEUCINE STIMULATION ON INSULIN SIGNALING%SMPDB%SMP0000682 Leucine Stimulation on Insulin Signaling 384783 56717 16337 16367 16334 64930 22084 13685 13684 11651 30955 104709 20539 HYPERPHENYLALANINEMIA DUE TO GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE DEFICIENCY%SMPDB%SMP0000487 Hyperphenylalaninemia Due to Guanosine Triphosphate Cyclohydrolase Deficiency 110391 20751 13361 11677 12408 19286 320415 14528 SUCCINYL COA: 3-KETOACID COA TRANSFERASE DEFICIENCY%SMPDB%SMP0000569 Succinyl CoA: 3-Ketoacid CoA Transferase Deficiency 110446 71911 15356 67041 BOPINDOLOL ACTION PATHWAY%SMPDB%SMP0000657 Bopindolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 CEREBROTENDINOUS XANTHOMATOSIS (CTX)%PATHWHIZ%PW000196 Cerebrotendinous Xanthomatosis (CTX) 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 SUCCINATE SIGNALLING%PATHWHIZ%PW084312 Succinate Signalling 15251 16176 21898 64384 216799 320452 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW122118 Glycogenosis, Type IC 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 ARTEMETHER METABOLISM PATHWAY%PATHWHIZ%PW000627 Artemether Metabolism Pathway 13114 394434 3-METHYLGLUTACONIC ACIDURIA TYPE III%SMPDB%SMP0000140 3-Methylglutaconic Aciduria Type III 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY%PATHWHIZ%PW000117 Pyruvate Dehydrogenase Complex Deficiency 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 REMIFENTANIL ACTION PATHWAY%PATHWHIZ%PW000422 Remifentanil Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 IRBESARTAN ACTION PATHWAY%PATHWHIZ%PW000281 Irbesartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 TRANDOLAPRIL METABOLISM PATHWAY%PATHWHIZ%PW000575 Trandolapril Metabolism Pathway 11421 NALBUPHINE ACTION PATHWAY%SMPDB%SMP0000691 Nalbuphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 18387 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 EXCITATORY NEURAL SIGNALLING THROUGH 5-HTR 4 AND SEROTONIN%PATHWHIZ%PW000441 Excitatory Neural Signalling Through 5-HTR 4 and Serotonin 14688 18749 19045 12912 14699 15562 ESTRONE METABOLISM%SMPDB%SMP0030880 Estrone Metabolism 71853 69191 12846 67838 12304 394436 19035 15485 64136 12282 13076 67397 14828 20860 MEDIUM CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (MCAD)%PATHWHIZ%PW000518 Medium Chain Acyl-CoA Dehydrogenase Deficiency (MCAD) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 BILASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW061119 Bilastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 THENALIDINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062894 Thenalidine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 TRASTUZUMAB ACTION PATHWAY%SMPDB%SMP0000476 Trastuzumab Action Pathway 13649 NIMODIPINE ACTION PATHWAY%PATHWHIZ%PW000395 Nimodipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 GNRH SIGNALING PATHWAY%PATHWHIZ%PW064816 GnRH Signaling Pathway 18750 18795 13649 18751 18747 14784 26419 110157 13712 26416 15461 60595 26401 16476 18805 14714 14715 14672 432530 26400 12288 17390 26395 26405 12322 17387 14308 16866 56808 20779 12295 11911 13653 12640 15200 12289 54652 12292 26397 26413 20662 16438 TENOXICAM ACTION PATHWAY%SMPDB%SMP0000706 Tenoxicam Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NISOLDIPINE ACTION PATHWAY%PATHWHIZ%PW000396 Nisoldipine Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FLUOROURACIL ACTION PATHWAY%SMPDB%SMP0000470 Fluorouracil Action Pathway 22171 INOSITOL METABOLISM%PATHWHIZ%PW088354 Inositol Metabolism 228550 83493 56208 225326 71780 228361 55980 66461 217837 56727 75678 269180 234729 23827 75669 17330 12462 170835 69718 18799 VERY-LONG-CHAIN ACYL-COA DEHYDROGENASE DEFICIENCY (VLCAD)%SMPDB%SMP0000540 Very-Long-Chain Acyl-CoA Dehydrogenase Deficiency (VLCAD) 11409 52538 231086 97212 11363 14081 66885 11370 12894 12896 270076 110446 93747 11364 ESCITALOPRAM ACTION PATHWAY%PATHWHIZ%PW000427 Escitalopram Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 TOLL-LIKE RECEPTOR PATHWAY 1%PATHWHIZ%PW064909 Toll-Like Receptor Pathway 1 26940 81897 26409 26419 14281 26398 12675 12475 117149 13712 26416 17087 26401 16476 21898 22034 18033 17874 18035 16151 19013 16150 19106 19697 26397 26399 54473 170743 16179 66513 142980 24088 68652 CARDIOLIPIN BIOSYNTHESIS%SMPDB%SMP0020986 Cardiolipin Biosynthesis 110911 66586 52123 66461 14732 74451 14555 T CELL RECEPTOR SIGNALING PATHWAY%SMPDB%SMP0066977 T Cell Receptor Signaling Pathway 18750 18803 18751 19353 16818 14784 18706 16797 20416 26419 26398 14281 110157 13712 15461 26401 16476 18708 18033 18035 14360 26395 19055 12501 19697 26417 22637 320139 19419 22190 12502 12503 19056 12500 18021 73181 18018 18019 20662 19057 640703 22324 30955 MERCAPTOPURINE METABOLISM PATHWAY%SMPDB%SMP0000609 Mercaptopurine Metabolism Pathway 63959 229363 13340 269346 22017 15452 11534 231327 11761 19353 23917 22436 27416 239273 114304 FELODIPINE METABOLISM PATHWAY%SMPDB%SMP0000619 Felodipine Metabolism Pathway 12288 56808 12295 ION CHANNEL AND PHORBAL ESTERS SIGNALING PATHWAY%SMPDB%SMP0090032 Ion Channel and Phorbal Esters Signaling Pathway 19229 18750 18803 18751 18442 MYOADENYLATE DEAMINASE DEFICIENCY%PATHWHIZ%PW000513 Myoadenylate Deaminase Deficiency 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 HOMOCYSTINURIA-MEGALOBLASTIC ANEMIA DUE TO DEFECT IN COBALAMIN METABOLISM, CBLG COMPLEMENTATION TYPE%SMPDB%SMP0000570 Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type 12411 108645 76467 66902 107869 13433 14204 320183 216443 232087 20425 17769 12116 20810 218865 MEQUITAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059720 Mequitazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 BUPIVACAINE ACTION PATHWAY%SMPDB%SMP0000393 Bupivacaine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 MNGIE (MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY)%PATHWHIZ%PW000190 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) 110074 69719 54369 320685 76952 76025 14544 68556 20135 76654 72269 22169 56248 72962 21877 16434 382985 64705 22171 99586 51797 103149 56749 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0063777 Nitric Oxide Signaling Pathway 18750 640703 18749 18125 11669 16438 22436 19055 14811 14810 13385 METHAPYRILENE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058741 Methapyrilene H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 WARBURG EFFECT%SMPDB%SMP0087420 Warburg Effect 55951 229699 74419 100043349 13806 56012 20525 66171 18655 66945 18563 67834 56451 66925 209692 20917 15275 14194 13382 235339 68263 15926 56421 18597 11428 78920 14751 14381 17449 18746 67680 66052 12974 19895 14661 14660 21351 110208 TALASTINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW058511 Talastine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 HYPOPHOSPHATASIA%SMPDB%SMP0000503 Hypophosphatasia 57028 216134 11647 103711 11761 PRAVASTATIN ACTION PATHWAY%SMPDB%SMP0000089 Pravastatin Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000567 Succinic Semialdehyde Dehydrogenase Deficiency 76282 229363 69719 14719 231327 97541 216456 54342 14415 14630 268860 67417 56174 212647 14629 14661 14583 14854 14782 214579 227231 14645 JOUBERT SYNDROME%SMPDB%SMP0000582 Joubert Syndrome 18718 224020 103199 18795 16331 13649 56208 52858 18711 18704 225326 13866 18707 18720 228361 234515 234729 75669 18708 19211 64436 104015 ADRENAL HYPERPLASIA TYPE 5 OR CONGENITAL ADRENAL HYPERPLASIA DUE TO 17 ALPHA-HYDROXYLASE DEFICIENCY%SMPDB%SMP0000372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia Due to 17 alpha-Hydroxylase Deficiency 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 FLUOXETINE ACTION PATHWAY%PATHWHIZ%PW000428 Fluoxetine Action Pathway 20266 11931 15550 11932 11549 107141 18549 11933 20264 13114 11928 98660 56808 12295 56448 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 APPARENT MINERALOCORTICOID EXCESS SYNDROME%SMPDB%SMP0000717 Apparent Mineralocorticoid Excess Syndrome 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 CYSTINOSIS, OCULAR NONNEPHROPATHIC%PATHWHIZ%PW000699 Cystinosis, Ocular Nonnephropathic 107869 14630 14718 14629 12583 83429 27267 246221 16828 BILE ACID DIRECT SIGNALLING PATHWAY (1)%PATHWHIZ%PW087627 Bile Acid Direct Signalling Pathway (1) 20186 28250 239273 227289 20494 OXIDATION OF BRANCHED-CHAIN FATTY ACIDS%SMPDB%SMP0000030 Oxidation of Branched-Chain Fatty Acids 16922 26874 14081 57279 11666 11669 12908 56794 12896 72129 56273 ARDEPARIN ACTION PATHWAY%SMPDB%SMP0000275 Ardeparin Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 CHLORCYCLIZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058931 Chlorcyclizine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FENOPROFEN ACTION PATHWAY%SMPDB%SMP0000696 Fenoprofen Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 NEURON FUNCTION%SMPDB%SMP0000224 Neuron Function 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOGEN STORAGE DISEASE TYPE 1A (GSD1A) OR VON GIERKE DISEASE%PATHWHIZ%PW121967 Glycogen Storage Disease Type 1A (GSD1A) or Von Gierke Disease 269614 55951 17448 21991 100043349 14377 13806 56012 319625 11674 67863 14121 14751 15277 18534 GLUT-1 DEFICIENCY SYNDROME%SMPDB%SMP0000580 GLUT-1 Deficiency Syndrome 18103 14430 216558 76025 14377 66588 16770 22232 20525 14595 ROFECOXIB ACTION PATHWAY%SMPDB%SMP0000087 Rofecoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 DIPHENYLPYRALINE H1-ANTIHISTAMINE ACTION%PATHWHIZ%PW059841 Diphenylpyraline H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 FLUOROURACIL METABOLISM PATHWAY%SMPDB%SMP0000608 Fluorouracil Metabolism Pathway 22171 DIHYDROMORPHINE ACTION PATHWAY%PATHWHIZ%PW000666 Dihydromorphine Action Pathway 20266 11931 15550 11932 11549 18549 11933 20264 11928 98660 56808 12295 12286 13162 20538 18976 15567 11444 11438 16508 18390 232975 14811 14810 13488 GLYCOGENOSIS, TYPE IB%PATHWHIZ%PW121893 Glycogenosis, Type IB 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 GENTAMICIN ACTION PATHWAY%SMPDB%SMP0000254 Gentamicin Action Pathway LESCH-NYHAN SYNDROME (LNS)%SMPDB%SMP0000364 Lesch-Nyhan Syndrome (LNS) 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 SORAFENIB METABOLISM PATHWAY%PATHWHIZ%PW000624 Sorafenib Metabolism Pathway 13114 13088 71853 69191 67838 394434 12304 394436 19035 64136 12282 67397 14828 72303 PRIMARY HYPEROXALURIA II, PH2%SMPDB%SMP0000558 Primary Hyperoxaluria II, PH2 17436 76238 18563 13382 235339 68263 18597 110446 17449 11677 60525 14651 109801 52815 11669 18770 18534 16828 107476 66204 74156 TRITOQUALINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0062895 Tritoqualine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY TYPE I%SMPDB%SMP0000237 3-Methylcrotonyl-CoA Carboxylase Deficiency Type I 11669 11409 15108 52538 15356 15360 66885 11761 67041 13382 56357 78038 12035 66948 11992 110446 58875 12039 72039 268860 12040 93747 227095 66904 110821 11364 13171 104776 SPHINGOLIPID METABOLISM%SMPDB%SMP0000034 Sphingolipid Metabolism 12091 11605 14420 268656 208449 14466 22239 66190 11883 22234 50877 20773 70750 20397 19012 56632 56386 433323 53897 223753 238011 70059 171168 21-HYDROXYLASE DEFICIENCY (CYP21)%SMPDB%SMP0000576 21-Hydroxylase Deficiency (CYP21) 110115 13070 13074 15492 15484 15483 13079 208665 15497 83702 13072 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000242 Dimethylglycine Dehydrogenase Deficiency 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 DIMETHYLGLYCINE DEHYDROGENASE DEFICIENCY%SMPDB%SMP0000484 Dimethylglycine Dehydrogenase Deficiency 104174 17161 67092 13382 14431 107869 11611 74129 27364 107272 11655 14711 20425 100678 353172 192166 11669 235582 231691 108037 20226 434437 26912 236539 GLYCOLYSIS%PATHWHIZ%PW088336 Glycolysis 18642 15277 21991 14377 100043349 13806 18770 56012 319625 11674 14751 CORTICOTROPIN ACTIVATION OF CORTISOL PRODUCTION%SMPDB%SMP0000310 Corticotropin Activation of Cortisol Production 14688 17200 18749 14699 18976 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120618 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 110006 22239 15275 14751 IFOSFAMIDE METABOLISM PATHWAY%PATHWHIZ%PW000581 Ifosfamide Metabolism Pathway 11670 11668 13114 13088 13087 72303 ESOMEPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000588 Esomeprazole Metabolism Pathway 11944 11945 NITRIC OXIDE SIGNALING PATHWAY%SMPDB%SMP0108236 Nitric Oxide Signaling Pathway 18750 18749 18125 12313 19055 14811 14810 13385 AHR SIGNAL TRANSDUCTION PATHWAY%PATHWHIZ%PW064763 Ahr Signal Transduction Pathway 11863 11622 15519 EGF SIGNALLING PATHWAY%SMPDB%SMP0120948 EGF Signalling Pathway 18750 18803 18751 20807 20848 14784 100039026 20416 13645 20850 26419 218397 16452 14281 110157 13712 15461 16476 26401 26400 26395 26417 13869 LYSOPHOSPHATIDIC ACID LPA6 SIGNALLING%PATHWHIZ%PW064749 Lysophosphatidic Acid LPA6 Signalling 14688 67168 11651 19877 432530 20807 14702 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0000064 Fructose and Mannose Degradation 234730 75454 22122 21991 75540 331026 15275 230163 11674 14121 18641 20322 11677 16548 218138 29858 18639 110119 GLYCOGENOSIS, TYPE VI. HERS DISEASE%SMPDB%SMP0120619 Glycogenosis, Type VI. Hers Disease 110006 22239 15275 14751 PRACTOLOL ACTION PATHWAY%PATHWHIZ%PW000646 Practolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 GLYCOGENOSIS, TYPE VII. TARUI DISEASE%SMPDB%SMP0120815 Glycogenosis, Type VII. Tarui Disease 18642 15277 21991 14377 100043349 13806 18770 56012 319625 11674 14751 PAMIDRONATE ACTION PATHWAY%PATHWHIZ%PW000273 Pamidronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 PROLIDASE DEFICIENCY (PD)%PATHWHIZ%PW000083 Prolidase Deficiency (PD) 18125 14718 18242 18408 19125 18416 67092 12709 14431 69051 11846 11898 320452 109900 13142 107508 109093 212647 14661 227231 BILE ACID BIOSYNTHESIS%SMPDB%SMP0000035 Bile Acid Biosynthesis 16889 208665 83702 93732 12642 20280 13123 104086 13124 13122 15488 17117 12012 26459 13116 101502 56050 ZOLEDRONATE ACTION PATHWAY%PATHWHIZ%PW000270 Zoledronate Action Pathway 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 GLUTATHIONE SYNTHETASE DEFICIENCY%PATHWHIZ%PW000073 Glutathione Synthetase Deficiency 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 CLOMIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000615 Clomipramine Metabolism Pathway 107141 13077 13114 56448 CLARITHROMYCIN ACTION PATHWAY%SMPDB%SMP0000248 Clarithromycin Action Pathway SULINDAC ACTION PATHWAY%PATHWHIZ%PW000136 Sulindac Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 LEVOMETHADYL ACETATE METABOLISM PATHWAY%PATHWHIZ%PW000614 Levomethadyl Acetate Metabolism Pathway 13113 FRUCTOSE AND MANNOSE DEGRADATION%SMPDB%SMP0063614 Fructose and Mannose Degradation 18642 14120 21991 15275 230163 11676 PROTEIN SYNTHESIS: HISTIDINE%PATHWHIZ%PW112929 Protein Synthesis: Histidine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 15115 27050 27370 GLYCEROL METABOLISM IV (GLYCEROPHOSPHOGLYCEROL)%PATHWHIZ%PW000917 Glycerol Metabolism IV (Glycerophosphoglycerol) RIBOSE-5-PHOSPHATE ISOMERASE DEFICIENCY%SMPDB%SMP0000519 Ribose-5-phosphate Isomerase Deficiency 21881 11674 66171 14751 14121 75456 14381 18641 19895 72157 71336 21351 66646 110208 232449 DESIPRAMINE METABOLISM PATHWAY%PATHWHIZ%PW000602 Desipramine Metabolism Pathway 20538 56448 15567 HYDROFLUMETHIAZIDE ACTION PATHWAY%PATHWHIZ%PW000335 Hydroflumethiazide Action Pathway 11931 11932 11933 11928 98660 69354 50934 56365 27411 110784 18399 20510 102680 20518 20278 20540 330836 17254 107723 20539 20276 20495 20497 20277 30962 20532 232975 INTRACELLULAR SIGNALLING THROUGH LHCGR RECEPTOR AND LUTEINIZING HORMONE CHORIOGONADOTROPIN%SMPDB%SMP0000338 Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone Choriogonadotropin 14688 12640 210044 18749 19045 16867 12912 14699 16866 LACTOSE DEGRADATION%SMPDB%SMP0000457 Lactose Degradation 20537 11931 11932 11933 11928 226413 98660 20526 232975 FRUCTOSE-1,6-DIPHOSPHATASE DEFICIENCY%SMPDB%SMP0000562 Fructose-1,6-diphosphatase Deficiency 55951 18563 17448 12183 21991 14377 75735 100043349 14385 13806 319625 20526 56012 11674 67863 14751 14121 18648 72157 15277 18534 16828 GLYCEROLIPID METABOLISM%SMPDB%SMP0000039 Glycerolipid Metabolism 15450 50784 14571 11670 11677 19012 235582 14732 55979 14555 16956 ETHANOL FERMENTATION%SMPDB%SMP0002356 Ethanol Fermentation 18746 21991 100043349 56421 14751 PENTOSE PHOSPHATE PATHWAY%PATHWHIZ%PW088358 Pentose Phosphate Pathway 14381 18641 19895 71336 21351 21881 11674 19139 14121 14751 SUCRASE-ISOMALTASE DEFICIENCY%PATHWHIZ%PW000533 Sucrase-Isomaltase Deficiency 216558 74185 14751 69983 232714 232493 110006 70974 72157 77559 100043686 15277 22235 103988 110095 TIGECYCLINE ACTION PATHWAY%PATHWHIZ%PW000689 Tigecycline Action Pathway DE NOVO TRIACYLGLYCEROL BIOSYNTHESIS%SMPDB%SMP0015896 De Novo Triacylglycerol Biosynthesis 14245 13350 14732 55979 14555 SPECTINOMYCIN ACTION PATHWAY%PATHWHIZ%PW000356 Spectinomycin Action Pathway HOMOCYSTINURIA, CYSTATHIONINE BETA-SYNTHASE DEFICIENCY%PATHWHIZ%PW000491 Homocystinuria, Cystathionine beta-Synthase Deficiency 107869 12411 HISTAPYRRODINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0058732 Histapyrrodine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 PANTOPRAZOLE METABOLISM PATHWAY%PATHWHIZ%PW000591 Pantoprazole Metabolism Pathway 11944 11945 VALSARTAN ACTION PATHWAY%SMPDB%SMP0000165 Valsartan Action Pathway 14688 11607 100038824 11606 11421 14702 14682 CARNOSINURIA, CARNOSINEMIA%SMPDB%SMP0000493 Carnosinuria, Carnosinemia 14415 268860 104776 11669 64705 99586 11754 103149 338403 GLYCOGENOSIS, TYPE IV. AMYLOPECTINOSIS, ANDERSON DISEASE%SMPDB%SMP0120837 Glycogenosis, Type IV. Amylopectinosis, Anderson Disease 110006 70974 71773 100043686 77559 216558 15277 22235 103988 110095 14751 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION%SMPDB%SMP0121131 2-Amino-3-Carboxymuconate Semialdehyde Degradation 237320 209692 13382 266645 78920 BEVANTOLOL ACTION PATHWAY%PATHWHIZ%PW000645 Bevantolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 PROTEIN SYNTHESIS: TRYPTOPHAN%PATHWHIZ%PW120526 Protein Synthesis: Tryptophan 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 22375 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 65019 27050 27370 PURINE METABOLISM%PATHWHIZ%PW000052 Purine Metabolism 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 INOSITOL PHOSPHATE METABOLISM%SMPDB%SMP0000462 Inositol Phosphate Metabolism 228550 327655 16329 71780 55980 234515 217837 75678 269180 17330 56409 27399 69718 ENOXAPARIN ACTION PATHWAY%SMPDB%SMP0000272 Enoxaparin Action Pathway 12842 110135 99571 18791 18815 14161 14068 11905 14060 14067 14066 74145 58992 109821 14058 16621 56316 14061 14071 27973 14069 SACCHAROPINURIA HYPERLYSINEMIA II%SMPDB%SMP0000239 Saccharopinuria Hyperlysinemia II 15107 209692 13382 270076 78920 110446 11988 23923 83885 93747 110695 19193 30956 ALIMEMAZINE H1-ANTIHISTAMINE ACTION%SMPDB%SMP0059689 Alimemazine H1-Antihistamine Action 14688 18795 18751 18033 16438 15465 14702 14682 MALONIC ACIDURIA%SMPDB%SMP0000198 Malonic Aciduria 13382 110446 12039 68738 268860 12040 93747 227095 66904 110821 11364 13171 104776 56690 106557 107476 73724 AROMATASE DEFICIENCY%SMPDB%SMP0000565 Aromatase Deficiency 13075 54200 100559 13074 20860 78925 208665 15497 15487 15485 GLYCOGENOSIS, TYPE IC%PATHWHIZ%PW121894 Glycogenosis, Type IC 71803 269614 74551 69719 55951 17448 68401 12183 21991 15275 230163 13806 319625 14751 14447 239606 18648 14120 KIDNEY FUNCTION - DISTAL CONVOLUTED TUBULE%SMPDB%SMP0121012 Kidney Function - Distal Convoluted Tubule 11931 11932 20497 11933 11928 194352 98660 11827 56365 100038824 11828 20541 11944 11945 232975 ARGININOSUCCINIC ACIDURIA%PATHWHIZ%PW000184 Argininosuccinic Aciduria 76282 55963 20514 14719 78830 18408 18416 216456 11846 11898 109900 14661 227231 FOSINOPRIL METABOLISM PATHWAY%SMPDB%SMP0000594 Fosinopril Metabolism Pathway 11421 PINDOLOL ACTION PATHWAY%PATHWHIZ%PW000374 Pindolol Action Pathway 20648 11931 11932 243764 11933 11938 58226 11928 18747 16521 98660 16535 12291 16493 330953 16523 20927 16514 20271 22004 16519 16520 11554 16518 12288 20541 20650 56543 16525 16509 56808 12295 13383 16511 20191 20928 246133 232975 19084 20649 FC EPSILON RECEPTOR I SIGNALING IN MAST CELLS%SMPDB%SMP0108224 Fc Epsilon Receptor I Signaling in Mast Cells 18750 16331 18803 14125 16163 16189 20963 16653 19353 17060 16818 14784 18176 17096 16797 12981 26419 14126 110157 15461 11651 18708 26400 14360 26395 26396 26413 21926 14389 SUCCINATE SIGNALLING DURING INFLAMMATION%SMPDB%SMP0084634 Succinate Signalling During Inflammation 18750 18795 12912 84112 26413 19094 18127 12675 19224 18033 16151 16150 26417 TAMOXIFEN ACTION PATHWAY%SMPDB%SMP0000471 Tamoxifen Action Pathway 20887 13982 14262 13114 14261 394433 13088 56448 394434 MITOCHONDRIAL DNA DEPLETION SYNDROME-3%SMPDB%SMP0000536 Mitochondrial DNA Depletion Syndrome-3 15452 75456 11564 16434 11486 23984 67054 67979 11636 229363 210044 14450 54369 76952 238871 53893 231327 229665 108147 11821 22436 23917 14923 66355 11566 54195 66401 12499 14544 27369 20135 20133 237823 18950 72090 22166 234889 D4-GDI SIGNALING PATHWAY%SMPDB%SMP0066935 D4-GDI Signaling Pathway 670717 18646 330914 11545 11855 11857 12370 12362 12367 11783 12371 16476 14939 FRUCTOSURIA%PATHWHIZ%PW121881 Fructosuria 18642 14120 21991 15275 230163 11676 ARACHIDONIC ACID METABOLISM%SMPDB%SMP0000075 Arachidonic Acid Metabolism 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 5-OXOPROLINURIA%PATHWHIZ%PW000074 5-Oxoprolinuria 71522 14775 12369 68252 14630 14629 14854 14782 68214 75475 16790 ETORICOXIB ACTION PATHWAY%SMPDB%SMP0000695 Etoricoxib Action Pathway 71519 14775 208285 17001 19223 13850 100040843 13088 13110 16993 11684 106648 105349 64292 19215 11689 11686 21391 11687 11688 19224 19225 12408 72303 14598 13106 72054 66469 PROTEIN SYNTHESIS: ASPARAGINE%SMPDB%SMP0111854 Protein Synthesis: Asparagine 20115 319195 67248 100043391 668182 241053 100040331 432502 670832 633683 100043184 667279 668144 100043755 100043209 382492 621100 665189 666899 67281 100042670 629957 100039316 667739 76846 225058 19921 100038875 100038991 100043876 267019 100043000 100043423 100042986 16785 20044 100043295 100040298 625646 622534 100042740 667618 56040 57294 666669 100040021 100040970 20085 20084 19899 67891 67097 19934 66481 67025 19941 14694 20055 27207 68193 67186 19989 19951 76808 75617 20103 20102 22121 70223 65019 27050 27370 FANCONI-BICKEL SYNDROME%PATHWHIZ%PW121892 Fanconi-Bickel Syndrome 18663 68401 12183 21991 15275 230163 13806 319625 56421 14751 14447 18746 239606 18648 INTRACELLULAR SIGNALLING THROUGH HISTAMINE H2 RECEPTOR AND HISTAMINE%PATHWHIZ%PW000449 Intracellular Signalling Through Histamine H2 Receptor and Histamine 14688 210044 18749 19045 12912 14699 15466 DESMOSTEROLOSIS%PATHWHIZ%PW000097 Desmosterolosis 73166 20652 66234 16889 235293 68603 18194 14593 110460 16987 192156 15357 110196 319554 14137 13121 15490 17855 13595 20775 74754 LYSOPHOSPHATIDIC ACID LPA3 SIGNALLING%SMPDB%SMP0063755 Lysophosphatidic Acid LPA3 Signalling 14688 18795 11651 432530 16438 14702 65086 THE ONCOGENIC ACTION OF 2-HYDROXYGLUTARATE%SMPDB%SMP0002291 The Oncogenic Action of 2-Hydroxyglutarate 269951 66945 55951 18563 67834 56451 66925 209692 20917 11429 216456 13382 14194 235339 68263 15926 170718 11428 18597 15929 78920 67680 66052 12974 GLYCEROL METABOLISM V (GLYCEROPHOSPHOSERINE)%SMPDB%SMP0121313 Glycerol Metabolism V (Glycerophosphoserine) ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME%R-HSA-1169091.2 Activation of NF-kappaB in B cells 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 19696 12042 66413 26965 667035 22190 18751 240354 59029 26409 67089 103583 70247 21762 22123 12675 108723 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 18037 26442 69077 66997 23997 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.3 Conjugation of phenylacetate with glutamine 117147 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.5 SUMOylation of intracellular receptors 22260 20181 22337 19013 56469 13982 22025 19883 11835 18227 14815 59004 20610 208727 19016 22196 100043429 110784 26423 19401 229615 21834 18667 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 96%5685942 HDR through Homologous Recombination (HRR) 20422 667035 22190 52864 19360 27015 69745 17535 21975 19363 19364 27354 12021 224008 60530 81601 327762 269400 59001 19361 114714 209334 22427 19687 19718 69263 15574 11920 66979 12189 12190 235610 231724 237911 19355 57434 225182 74335 26909 18538 235559 71711 12144 381306 68275 106344 72151 18971 68240 18972 233826 19891 18973 18974 80905 19367 19356 19362 67967 268465 12649 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.4 Phosphorylation of the APC C 52717 99152 668450 12534 217232 56317 59008 18817 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876384 Listeria monocytogenes entry into host cells 12388 12387 58194 12550 20408 12402 56324 20779 15239 20404 17295 20844 20405 13858 104836 667035 22190 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 96%187687 Signalling to ERKs 107746 109880 12929 26416 12928 56044 64143 18049 216148 26413 26417 29857 20416 327826 18211 109905 77480 19094 20418 102626 19730 54401 26415 26395 26396 19762 18176 20662 19769 15461 17164 DISEASES OF THE UREA CYCLE%REACTOME%R-HSA-9955698.1 Diseases of the urea cycle 217214 11898 109900 227231 18408 18416 67824 11846 HEME SIGNALING%REACTOME DATABASE ID RELEASE 96%9707616 Heme signaling 328572 15129 17087 15368 15122 12013 21372 109151 11806 56760 17977 238055 19017 18143 103573 17135 17978 59035 81004 66993 17260 17261 21898 12753 18024 268903 70461 15183 20185 93759 217166 74343 12914 20181 382056 56406 19013 11909 19883 19014 229003 11865 19377 70804 52466 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME DATABASE ID RELEASE 96%1168372 Downstream signaling events of B Cell Receptor (BCR) 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 19696 12042 66413 26965 667035 22190 18751 240354 59029 26409 67089 103583 70247 18176 15461 640703 268373 19055 19056 19419 18018 18019 21762 240168 22123 19058 12675 14225 108723 18021 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 18037 26442 69077 66997 23997 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME%R-HSA-8862803.4 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 14103 12532 12380 12333 12334 12336 20656 56484 16476 69543 18477 21672 16906 22627 12569 12568 11820 99412 12125 12530 12531 SLC-MEDIATED BILE ACID TRANSPORT%REACTOME%R-HSA-9958517.1 SLC-mediated bile acid transport 100434 213603 242259 75750 70129 68682 63993 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 96%2644605 FBXW7 Mutants and NOTCH1 in Cancer 26965 18128 21402 56438 CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373080 Class B 2 (Secretin family receptors) 57265 13733 381853 14607 22226 14697 93897 19206 54598 22412 216795 19226 14710 14699 66066 14700 22410 93896 22414 22411 14708 14706 22409 12310 14704 11516 14695 14652 11517 12311 14693 20423 64337 14709 15874 12921 12919 22417 12918 14701 114640 223780 54409 19227 19228 56089 213527 51801 13363 14602 14601 319757 11535 14702 93735 83428 14696 14527 14526 14367 14365 26364 14362 22415 14366 22413 22416 22420 22418 14370 22354 22422 14371 22421 22353 20287 14368 22423 14369 22355 20890 19207 14688 22408 16147 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.3 Regulation of RAS by GAPs 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70247 18176 15461 26554 226525 18015 320484 211255 240057 101809 54153 114715 21762 114716 22123 19414 69601 19415 19179 218397 19181 114713 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%888568 GABA synthesis 14415 14417 CS DS DEGRADATION%REACTOME%R-HSA-2024101.6 CS DS degradation 11881 15931 12111 121021 13004 244757 29873 13003 110006 77042 15586 109685 70893 15212 15211 12032 13179 15932 12091 DISEASES OF MITOTIC CELL CYCLE%REACTOME%R-HSA-9675126.4 Diseases of mitotic cell cycle 52717 99152 668450 12575 22589 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 56371 27401 13163 12448 12577 12576 217232 56317 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702596 lestaurtinib-resistant FLT3 mutants 14255 RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2500257 Resolution of Sister Chromatid Cohesion 12534 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 218914 12235 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 100710 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 12442 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 71521 13426 52504 13424 228421 20843 381306 18817 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND ALVEOLAR CELLS%REACTOME%R-HSA-9927426.2 Developmental Lineage of Mammary Gland Alveolar Cells 19109 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 96%5423599 Diseases of Mismatch Repair (MMR) 17685 17686 17350 17688 18861 VASOPRESSIN-LIKE RECEPTORS%REACTOME DATABASE ID RELEASE 96%388479 Vasopressin-like receptors 18429 11998 18430 54140 26361 12000 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 96%1483101 Synthesis of PS 19210 27388 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME DATABASE ID RELEASE 96%351906 Apoptotic cleavage of cell adhesion proteins 12367 18772 109620 13512 12387 12550 21873 13511 13510 21872 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.4 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME DATABASE ID RELEASE 96%2395516 Electron transport from NADPH to Ferredoxin 14149 14148 68165 DEFECTIVE MUTYH SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9608290 Defective MUTYH substrate processing COSTIMULATION BY THE CD28 FAMILY%REACTOME DATABASE ID RELEASE 96%388841 Costimulation by the CD28 family 233833 53859 16451 21415 232440 12387 13200 13626 319149 72297 22628 320207 16478 16842 22612 11651 11652 22324 15077 269523 66310 18710 140858 97064 18566 230979 52615 26410 19646 213464 14360 12988 11910 214162 13001 13000 100039026 17869 245688 20747 12500 22601 12501 12502 15251 17096 23808 12504 18109 244373 18005 17444 78757 228775 60533 76580 108099 16362 30955 18708 18709 18479 12477 18706 18607 328572 74769 18707 66357 12487 12519 12524 21414 21416 231051 18481 18024 12914 16476 56438 26554 12567 12443 73699 19052 19053 51792 226849 225849 26931 21770 26932 21762 22123 19179 19181 19182 23996 19184 18033 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 21679 15267 21676 319168 21678 319167 14281 224105 226144 75778 76850 239528 319186 21677 319178 319183 319182 193670 54197 236511 319190 26754 241113 14282 56717 70377 319176 18034 216440 319181 19353 20014 213988 57261 103963 217351 56637 214150 69038 227743 13135 19247 13819 14969 14968 66753 104709 67819 208154 14056 15170 116891 17454 20338 319169 109270 50723 67075 105787 108079 20846 19079 20848 108097 625328 78303 319188 15270 58205 16818 19082 80286 56716 624153 68292 23797 16430 382522 TRANSCRIPTION OF THE HIV GENOME%REACTOME%R-HSA-167172.4 Transcription of the HIV genome 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 229906 235459 24074 83602 58202 68153 74197 67923 27224 27632 24116 12455 72949 13716 63856 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%190872 Transport of connexons to the plasma membrane 14609 14619 PROTEIN FOLDING%REACTOME%R-HSA-391251.3 Protein folding 12469 21371 12461 14466 12464 30050 108903 50762 72726 14675 53857 24012 24128 19739 22327 22152 227613 50782 14697 22153 12447 50754 216853 56327 50779 22142 12448 11461 14710 22146 14699 14976 66066 67199 14700 18637 108077 67466 67951 27055 14708 13001 71833 14706 13000 14672 100039026 14447 213980 14704 66411 73710 14695 68628 14676 22145 22059 14693 12465 16553 64337 55946 14709 50789 545486 238463 30839 14682 67134 14701 109054 56612 20698 99371 14702 14696 15183 14688 20848 12466 22147 21454 12462 22151 106052 70430 66887 242960 12467 30838 12468 22143 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176033.4 Interactions of Vpr with host cellular proteins 18141 23825 107939 69482 71805 11739 433923 11740 54563 16646 19069 15361 70699 101739 72787 18226 218210 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 96%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components 52717 99152 668450 56150 12237 107995 217232 56317 12236 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.3 Alternative Lengthening of Telomeres (ALT) 22589 13163 E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 96%113507 E2F-enabled inhibition of pre-replication complex formation 50793 18392 18393 12534 66634 26428 26429 56452 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 96%112303 Electric Transmission Across Gap Junctions 14615 14610 55991 14617 406218 INFLUENZA INFECTION%REACTOME DATABASE ID RELEASE 96%168255 Influenza Infection 622534 238217 74568 16785 666669 100040021 67025 100043391 668182 241053 12317 432502 100038882 19989 76808 19899 100043184 19921 19934 100043755 11545 193740 12330 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 16211 100039592 16648 19106 100037258 19386 100043876 100043893 100043423 100042986 20115 67281 54196 76846 625646 100040298 68172 100042740 19951 381686 16649 70572 19384 667618 100040970 267019 56040 67248 445007 100040331 67941 57294 103573 69912 103468 234865 59015 69736 110379 68705 98053 667035 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 170762 108989 231042 227699 223921 227720 269113 66679 18141 107939 69482 71805 11740 54563 16646 19069 70699 72787 18226 218210 27207 67097 670832 231413 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 21803 20103 668668 667739 54188 67300 672214 12757 66481 225058 100038875 100038991 68028 100043000 67891 100043295 DEFECTIVE ALG14 CAUSES ALG14-CMS%REACTOME DATABASE ID RELEASE 96%5633231 Defective ALG14 causes ALG14-CMS 66789 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME%R-HSA-8939245.2 RUNX1 regulates transcription of genes involved in BCR signaling 69257 13709 12143 18507 12400 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.5 Vitamin B5 (pantothenate) metabolism 14104 74450 73095 71743 75735 68087 211347 67618 269614 106564 72621 66812 73132 26464 22361 18605 18606 330064 209558 SLC-MEDIATED TRANSPORT OF OLIGOPEPTIDES%REACTOME%R-HSA-9959399.1 SLC-mediated transport of oligopeptides 65221 56643 83429 100561 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME%R-HSA-159236.5 Transport of Mature mRNA derived from an Intron-Containing Transcript 386612 17149 100040029 19386 170762 108989 231042 227699 223921 227720 445007 269113 66679 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 64340 622469 69912 225027 67996 225160 51796 56488 103468 192160 331401 71713 53817 233073 625193 69823 234865 20382 110809 73666 60365 20383 59015 68278 69736 170722 70579 21681 73826 68134 110379 66231 66511 107829 108014 53319 192170 69207 19826 193116 74412 66441 FORMATION OF THE POSTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9832991 Formation of the posterior neural plate 14472 24136 225207 18991 18424 20664 14179 21389 20674 22416 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.6 Small interfering RNA (siRNA) biogenesis 22099 236511 214150 192119 76850 23992 239528 53424 21357 TRP CHANNELS%REACTOME%R-HSA-3295583.4 TRP channels 225997 22063 193034 22065 22067 22066 28240 22068 63873 171382 171166 56407 68667 277328 64177 17364 246788 68279 94178 22368 226025 194352 26946 56843 58800 DEVELOPMENTAL LINEAGE OF PANCREATIC DUCTAL CELLS%REACTOME%R-HSA-9925563.2 Developmental Lineage of Pancreatic Ductal Cells 16775 16776 16777 16779 16780 226519 14268 16782 16772 23928 16773 16774 22370 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME%R-HSA-164940.5 Nef mediated downregulation of MHC class I complex cell surface expression 252903 15007 12010 11768 11769 108012 11764 107975 11765 11767 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME%R-HSA-1299308.2 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 52150 16525 16530 PROTEASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9907900 Proteasome assembly 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 59029 67089 70247 69666 16912 19171 107047 66537 19185 19192 73902 66998 56088 67151 53380 66506 16913 228769 103554 19186 19188 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 FCERI MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-2871837.4 FCERI mediated NF-kB activation 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 12042 66413 26965 667035 22190 240354 59029 26409 67089 103583 70247 17096 18607 100041766 216150 66513 93765 66589 18761 22034 19395 66724 233046 68652 19419 21762 22123 12675 108723 19179 19181 19182 23996 19184 18033 26440 19166 216080 18035 19167 26441 26442 69077 66997 23997 TRANSCRIPTIONAL AND POST-TRANSLATIONAL REGULATION OF MITF-M EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9856649.3 Transcriptional and post-translational regulation of MITF-M expression and activity 21943 17342 20665 20682 18992 12387 15901 209446 12550 17202 107508 22628 17201 21425 20674 16842 26413 26417 54401 22196 328572 103573 22416 56637 93759 12914 21426 20583 20111 107045 226414 97541 17169 216443 18505 22631 13616 22629 105148 15254 231872 13614 66143 22771 18976 17199 433759 13618 16590 22627 15221 12977 104458 11694 21386 23797 85305 17203 13722 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209968 Thyroxine biosynthesis 13371 13370 70337 12389 213696 114479 107585 22094 214593 99439 66811 106200 12640 22018 AZATHIOPRINE ADME%REACTOME DATABASE ID RELEASE 96%9748787 Azathioprine ADME 22325 214254 13340 269346 15452 22017 63959 100042069 14863 23917 14923 57257 19353 22324 18102 18103 229363 27416 239273 114304 22436 RHOBTB GTPASE CYCLE%REACTOME%R-HSA-9706574.4 RHOBTB GTPase Cycle 26891 56320 12461 109711 12539 20462 69288 242202 15519 51796 26554 53817 246710 50875 19877 15381 83946 106504 109331 11465 12466 12848 19230 17920 22352 19878 76626 56381 19655 53382 15516 12468 100043806 269061 UNWINDING OF DNA%REACTOME%R-HSA-176974.4 Unwinding of DNA 12544 69270 66634 109145 17216 272551 17215 17217 17218 17219 17220 78833 NGF PROCESSING%REACTOME DATABASE ID RELEASE 96%167060 NGF processing 18552 18550 18553 18049 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME%R-HSA-3642278.3 Loss of Function of TGFBR2 in Cancer 21803 21812 21813 MTOR SIGNALLING%REACTOME%R-HSA-165159.9 MTOR signalling 233833 11651 11652 54401 108099 76850 239528 236511 241113 56717 213988 217351 214150 12283 20869 64930 13631 75705 66508 545987 13685 13684 18655 54170 72149 208643 22084 52187 17454 68576 66096 83409 74370 68441 19042 105787 268706 14225 108079 69008 67605 19079 227154 245670 108097 667739 19082 56716 23797 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 96%5579007 Defective ACY1 causes encephalopathy 109652 CLOSTRIDIUM NEUROTOXICITY%REACTOME DATABASE ID RELEASE 96%168799 Clostridium neurotoxicity 56216 20980 64176 22317 64051 22318 20614 20979 20907 75209 APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME%R-HSA-5467333.3 APC truncation mutants are not K63 polyubiquitinated 11789 TYPE II NA+ PI COTRANSPORTERS%REACTOME%R-HSA-427589.3 Type II Na+ Pi cotransporters 20505 142681 20531 IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME DATABASE ID RELEASE 96%5603027 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) 16151 12675 16150 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 96%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 73166 231070 270669 110196 14137 100040592 20683 66397 18044 18045 18046 235293 68603 69608 218811 14732 99683 20775 20249 235623 192156 170439 72999 13121 20788 13360 107476 100705 14593 16987 17764 56453 77371 20181 319554 16211 17855 19013 20334 19384 19014 229003 14104 21372 109151 17977 17978 59035 81004 66993 12914 56406 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME DATABASE ID RELEASE 96%451308 Activation of Ca-permeable Kainate Receptor 110637 640703 14807 14806 13385 14805 52589 53310 13383 14809 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME DATABASE ID RELEASE 96%8875360 InlB-mediated entry of Listeria monocytogenes into host cell 20405 13858 58194 667035 22190 20408 12402 56324 15239 20404 17295 20844 MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.4 Maturation of protein E 667035 22190 REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5218859 Regulated Necrosis 14103 74568 12367 667035 22190 15519 22059 66371 14939 14102 68953 16176 75608 12362 14251 18571 12363 22195 22035 16362 50873 16396 208092 12370 66700 19766 11797 56532 670717 14252 12539 16173 22030 108155 16363 56424 21933 67245 69146 11796 11798 12018 50701 22061 53378 105513 16175 12028 54722 434174 71609 14082 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME DATABASE ID RELEASE 96%5619053 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) 20520 REELIN SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%8866376 Reelin signalling pathway 58194 22359 19699 13131 14360 CRISTAE FORMATION%REACTOME DATABASE ID RELEASE 96%8949613 Cristae formation 227112 17827 57423 68653 66477 76614 224904 11958 11957 68117 230935 216821 11947 66075 11949 433771 68055 68316 17705 11946 15526 66098 66043 11950 53375 100041835 100039108 432676 228033 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME%R-HSA-110314.5 Recognition of DNA damage by PCNA-containing replication complex 76843 59001 19687 19718 56438 69263 66979 667035 22190 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 67967 99375 69745 22210 72584 58186 230484 13194 67561 ION HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%5578775 Ion homeostasis 269717 11931 14226 11932 11933 11937 11938 65973 53313 109305 56188 76757 16514 109552 67972 11941 320707 381290 22063 12322 12323 108058 12325 20192 20191 20866 110891 20190 229709 16438 16439 13400 18747 11928 98660 232975 640703 20541 57780 18125 110893 16440 59095 20928 108017 21954 ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687136.2 Aberrant regulation of mitotic exit in cancer due to RB1 defects 52717 99152 668450 19645 217232 56317 59008 66156 56371 216080 27401 69957 17222 75430 68612 52563 22194 68999 52206 100039535 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559583 Cellular Senescence 52717 233833 99152 668450 232440 15901 12575 13626 319149 211586 13555 19645 21781 12571 12567 12566 15077 13557 12447 242705 56371 26416 12448 52615 12576 19646 26413 26417 19094 245688 102626 110651 20112 12418 15364 665113 17164 28113 77683 101185 15260 22166 29817 75560 56702 50709 14957 50708 14958 12151 26408 17248 17165 19763 80838 66403 12428 17246 54383 13619 110147 26399 57321 26400 241915 12416 26398 26420 26414 26397 13875 319152 104248 19821 21749 497652 21750 23939 100043858 12580 216850 12579 12578 16193 23872 23871 50932 26921 494448 15977 26419 12427 170644 12608 30951 16476 18033 16906 20683 19697 667035 22190 22059 15267 319168 319167 14281 19360 17535 76850 319186 27354 319178 319183 319182 81601 236511 319190 15361 319176 11920 319181 213988 16175 217351 214150 14056 20111 17454 319169 20848 217232 56317 625328 59008 78303 319188 66156 15270 216080 69957 17222 75430 68612 52563 624153 22194 68999 52206 100039535 382522 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.2 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 12448 12577 12576 SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 96%9006115 Signaling by NTRK2 (TRKB) 327826 20779 12064 14812 18176 14388 20662 21844 19353 18212 15461 208869 18205 107971 78405 18803 12569 12568 18708 19247 18706 NFE2L2 REGULATING TUMORIGENIC GENES%REACTOME%R-HSA-9818030.1 NFE2L2 regulating tumorigenic genes 12914 328572 20683 11839 12043 18024 18590 13645 12048 18128 17135 EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.4 Eukaryotic Translation Elongation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 13629 68028 67160 100043000 66656 67891 55949 100043295 13628 INHIBITION OF TSC COMPLEX FORMATION BY AKT (PKB)%REACTOME%R-HSA-165181.5 Inhibition of TSC complex formation by AKT (PKB) 22084 64930 23797 11651 11652 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-2691230.3 Signaling by NOTCH1 HD Domain Mutants in Cancer 18011 13388 16449 240055 225164 11487 54485 11491 16450 18128 667035 76580 22190 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%389357 CD28 dependent PI3K Akt signaling 74769 53859 18707 12487 12519 12524 320207 56717 11651 11652 18710 227743 26410 14360 104709 109270 78757 228775 16818 30955 56716 18708 75778 18709 23797 18706 18607 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 96%191859 snRNP Assembly 18141 107939 69482 71805 54563 107686 384091 19069 666609 68092 216766 70699 66069 621705 72787 20595 433702 18226 66603 218210 53975 12729 276919 20641 27374 20638 56698 70465 69731 432803 67332 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.3 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives 19225 11689 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME%R-HSA-1296025.4 ATP sensitive Potassium channels 20928 16514 16523 20927 ACTIVATION OF C3 AND C5%REACTOME DATABASE ID RELEASE 96%174577 Activation of C3 and C5 15139 14962 12263 12266 625018 DIGESTION%REACTOME%R-HSA-8935690.7 Digestion 14917 11722 76768 12613 14916 69060 18946 109791 18947 58866 69983 67717 232714 69656 14915 81600 71884 226413 100043686 RECYCLING OF EIF2:GDP%REACTOME%R-HSA-72731.4 Recycling of eIF2:GDP 13665 67204 108067 217715 26905 13667 209354 224045 P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69580.5 p53-Dependent G1 S DNA damage checkpoint 56436 17463 57296 20422 26445 26446 12575 19172 19173 19175 19177 26443 26444 12566 19170 12447 66413 667035 22190 12448 59029 12576 67089 70247 22059 17248 29813 59092 26374 50883 228829 12428 17246 11920 12578 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME DATABASE ID RELEASE 96%5619083 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) 229782 REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.5 Regulation of BACH1 activity 12013 26965 50758 27401 667035 22190 21402 56438 17135 SLC-MEDIATED TRANSPORT OF AMINO ACIDS%REACTOME%R-HSA-9958863.1 SLC-mediated transport of amino acids 103098 53896 56774 242607 14411 30962 20532 215113 67760 50934 209837 20513 21366 20514 215335 11989 234967 55963 69354 74338 76257 20511 20510 102680 20512 20540 330836 72401 246049 17254 11987 214663 105727 20539 26570 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.5 Maturation of spike protein 71164 53618 66357 20448 227619 19089 13200 208884 20014 103963 12330 69038 13135 103534 57377 67075 27801 228136 75965 70546 108687 269181 57437 217664 69035 107895 20446 20444 20442 20443 80286 17308 17158 20440 68292 67569 14376 16430 20447 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 96%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 640703 12326 14811 13385 18039 14810 53310 11472 13383 320472 23859 14812 14814 68606 52163 14813 12322 12323 108058 12325 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME%R-HSA-9662834.2 CD163 mediating an anti-inflammatory response 16193 217344 20620 93671 18550 16153 17886 26416 11491 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 96%168316 Assembly of Viral Components at the Budding Site 12330 12317 ALPK1 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%9645460 ALPK1 signaling pathway 68652 71481 667035 211550 22190 66513 26409 22034 66724 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME%R-HSA-141430.3 Inactivation of APC C via direct inhibition of the APC C complex 52717 99152 668450 56150 12237 107995 217232 56317 12236 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 GENERIC TRANSCRIPTION PATHWAY%REACTOME%R-HSA-212436.13 Generic Transcription Pathway 20682 12389 12640 18550 20869 64930 66508 545987 54170 22084 52187 68576 66096 83409 74370 68441 19042 268706 245670 20683 18044 18045 18046 14732 14102 12362 16396 670717 56424 21933 22061 12028 12322 12323 108058 12325 18747 12418 77683 22166 12151 17248 17165 19763 12428 17246 54383 13619 110147 26399 241915 12416 19821 12579 12578 16193 494448 12427 12608 30951 12064 14812 13388 16449 27374 29813 59092 50883 228829 12326 14811 20620 70625 68975 13865 243963 234959 12419 21418 76184 94112 15213 67268 70208 17988 21849 69020 13649 21802 14723 55948 94093 228876 15111 67731 268417 14751 23942 209225 56771 50493 21825 80509 104625 22160 21815 67911 214669 226896 240068 13395 108083 21833 15257 13038 77827 18983 98386 13039 210104 384763 239985 72611 269704 12702 14462 16854 14461 228839 14460 71361 14463 16477 233107 14776 56310 72780 237775 208043 26896 14800 15258 218772 19411 103988 52897 75747 80707 54526 16880 14534 17700 244556 12857 110109 619310 12450 12452 69131 30944 237758 53621 110323 19664 72068 14579 12861 232791 19650 17863 19651 12862 17865 12868 68943 66142 216848 232232 12866 12865 233056 100041785 208836 77519 109648 18129 18131 170936 18132 107932 666581 12662 675812 72119 243834 170787 18148 53376 19211 333182 22775 239546 230899 75605 68428 16184 216456 16183 434377 66494 110052 100039786 19712 19713 71131 619331 26992 243906 15510 22648 381549 71063 319974 68742 235682 68094 83796 83797 57376 72720 19246 243743 244713 544922 380975 72306 268936 229542 434178 22658 12705 22750 17684 23988 67279 19258 72154 59027 67057 225872 17283 17992 69076 18718 18741 74400 15228 56353 230162 72723 22704 14229 22757 226830 70315 21349 210135 93836 193452 11864 67821 244349 80902 13866 13864 74747 210503 93681 57264 232784 330301 74120 18519 449521 245368 15370 109594 17702 22654 16909 11783 56707 16825 57745 69562 242109 64384 22761 30942 15378 195522 77044 18534 103836 22632 20750 269870 12020 20393 20375 22696 18854 245595 56314 353187 70227 79221 110616 11816 59024 327987 72180 236193 432769 66105 67296 52712 231866 233904 22294 20135 234725 192292 83766 80751 23957 21907 11350 20482 74570 20481 20183 20182 71041 75410 101095 238690 17125 17126 17127 17128 69181 75692 76073 17192 12741 66313 17130 21981 17131 17132 228140 67235 268859 56744 103806 56525 14312 16600 70088 13496 53325 69125 22640 209456 11604 219024 228491 219103 333639 22284 56456 18124 66813 53892 22062 319801 213011 223272 99890 69790 22678 68527 58184 19885 243372 22026 225998 52679 50496 22608 13559 104394 241764 12858 93760 233893 66923 107986 353310 76390 21762 13198 22123 14634 13197 14633 19179 57748 19181 14660 19182 67956 23996 268973 19184 75788 18033 230784 26440 16653 19166 170826 20463 19167 170574 12981 26441 12978 74352 26442 64050 69077 76367 66997 381022 23997 69260 14381 56436 14377 17463 78893 57296 19293 20422 70472 26445 16334 26446 327963 19172 69228 19173 225655 19175 56458 19697 239652 19177 52846 21402 94223 78251 26443 21388 26444 18091 332937 19170 21423 231464 232854 66413 22709 26965 16179 667035 18387 22190 18390 18751 64058 240064 59029 21408 13983 67089 75613 14219 70247 21406 68744 22260 17708 20181 17709 22337 17710 19013 22693 16408 13982 12795 22025 14431 19883 26913 11835 72739 18227 72556 14815 26381 272347 26380 208727 26379 19016 57913 22196 16399 12366 16401 26423 16402 19401 106931 12368 21834 20787 18667 233060 69234 19360 56338 13831 264064 17535 12053 21975 12359 18022 19364 84682 27354 15978 12021 12843 12842 20807 81601 56187 327762 54601 19352 17386 19361 330463 170740 243621 22427 333654 12399 19718 192651 69263 20371 15574 20604 11920 16009 16006 12189 83814 22689 235610 68036 231724 12227 237911 15185 19355 12122 66262 225182 12142 15184 26909 22751 18538 27274 235559 11863 17433 12144 20527 216154 68275 20467 106344 78783 72151 211651 14088 68240 51813 12156 252870 19891 72230 15469 212712 12177 19367 69792 19356 12417 15205 20878 20466 12649 108961 217232 18996 56317 18997 59008 67381 19015 66156 72805 216080 12905 69957 219022 17222 22339 75430 56222 68612 666311 52563 15182 22194 71393 68999 15194 52206 12226 100039535 319530 52717 244219 99152 22690 668450 17187 12534 100041581 56275 12387 20602 11906 23989 67155 20586 170753 20779 20588 20587 56461 17295 60599 67338 270118 235956 13345 21936 241196 235028 26416 433766 66214 12005 29808 16656 234366 26413 18787 26417 240087 77976 12545 107568 67370 28077 56233 19094 234594 382985 15214 244216 54401 171285 21420 21419 19014 11865 328572 21372 19017 103573 59035 81004 66993 17260 15183 20185 93759 217166 12914 11909 640703 18019 20656 56484 16476 18477 21672 22627 12569 12568 12125 14103 12532 18128 56438 12918 16147 14415 14417 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 12447 56371 27401 13163 12448 12576 73699 11799 19052 19053 51792 20877 26931 18861 17685 17350 21872 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 20924 23894 14884 21679 15267 21676 319168 21678 319167 14281 76850 239528 319186 21677 319178 319183 319182 236511 319190 241113 56717 319176 319181 213988 217351 56637 214150 227743 19247 14056 17454 319169 109270 105787 108079 20846 19079 108097 625328 78303 319188 15270 19082 56716 624153 23797 382522 233833 21415 232440 13626 319149 22628 16842 22612 11651 11652 15077 66310 140858 97064 52615 19646 213464 214162 13001 13000 100039026 17869 245688 22601 23808 78757 108099 12477 18607 21414 21416 231051 270627 228980 319944 21374 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 24074 58202 67923 27224 27632 24116 12455 72949 13716 63856 22059 21803 11545 69257 13709 12143 18507 12400 225207 20674 22065 18761 22631 22629 18976 433759 16590 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME%R-HSA-6802955.4 Paradoxical activation of RAF signaling by kinase inactive BRAF 16706 20779 12322 109880 12323 108058 12325 26413 26417 12988 109905 640703 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 16653 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.2 Biosynthesis of D-series resolvins 16993 15446 11689 XENOBIOTICS%REACTOME DATABASE ID RELEASE 96%211981 Xenobiotics 13087 13107 13106 622127 11624 11622 72303 107141 13088 13077 56448 13076 13114 74134 72082 13110 13113 545817 11863 11864 IRON UPTAKE AND TRANSPORT%REACTOME%R-HSA-917937.6 Iron uptake and transport 71902 59049 73649 21402 26965 667035 22190 68428 94178 52466 15368 11428 18174 242341 68775 53945 15369 30926 76252 11972 108664 66290 67634 18002 14325 117167 11964 26357 110935 11966 100039636 66335 11973 11974 15203 74915 14319 338375 21871 73834 12870 114143 66237 11975 22041 54411 27060 64602 16819 242960 140494 22042 50765 15216 66144 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME DATABASE ID RELEASE 96%69017 CDK-mediated phosphorylation and removal of Cdc6 52717 56436 99152 17463 668450 57296 23834 20422 26445 26446 19172 19173 19175 19177 26443 26444 12566 19170 12447 66413 56371 667035 22190 12448 59029 67089 70247 12428 12427 21762 22123 19179 19181 19182 217232 23996 56317 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-HSA-1606341.4 IRF3 mediated activation of type 1 IFN 56480 446099 54131 207521 58203 SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.4 Sodium Proton exchangers 110895 20544 226999 236794 331004 77031 236727 105243 277973 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 96%1234158 Regulation of gene expression by Hypoxia-inducible Factor 12914 328572 13856 17684 230099 22339 15251 11863 13819 BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE DEFICIENCY%REACTOME%R-HSA-9912481.1 Branched-chain ketoacid dehydrogenase kinase deficiency 12040 12041 13171 13382 12039 COLLAGEN CHAIN TRIMERIZATION%REACTOME%R-HSA-8948216.4 Collagen chain trimerization 12843 12832 12842 12817 12816 12815 12814 12831 12813 94216 12830 373864 12821 107581 77018 12819 53867 12829 12828 12827 12826 12825 69700 12824 12822 71355 12841 12823 73368 12840 213945 12818 245026 140709 237759 12839 329941 12837 12836 12835 12834 12833 LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.6 Lipoprotein metabolism 270669 66397 11816 667035 22190 56453 22260 18747 16891 100017 30924 68453 103161 93835 100102 57875 11806 67963 11307 105847 238055 22259 18453 16956 65969 11303 11771 18552 11772 18550 66113 18553 71770 232345 13909 218203 320024 22359 223920 11657 11807 11808 18145 20652 16816 17777 56636 624219 15450 76483 232910 11773 11812 16835 11813 11814 11425 110611 27801 208677 54135 18749 171504 16889 67300 12757 MPS VII - SLY SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953080 MPS VII - Sly syndrome (CS DS degradation) 110006 NADPH REGENERATION%REACTOME%R-HSA-389542.5 NADPH regeneration 15926 11428 CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 96%71387 Carbohydrate metabolism 72297 27416 14751 103988 18655 640703 20544 14447 170762 108989 231042 227699 223921 227720 269113 66679 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 18749 68961 29873 338362 13003 76969 110006 74637 77042 328779 15586 23971 109685 23972 70893 319415 15212 78923 15211 11676 12032 18682 13179 14387 18534 15932 11677 12091 18295 11881 76898 15931 68631 12111 212898 121021 14385 13004 114332 244757 56043 66646 14595 15277 15275 17022 78752 75612 192188 50935 60322 269941 108902 80908 218271 14264 105193 14121 19746 545291 14120 70484 110078 110095 19309 23908 15529 18747 23888 20971 14635 74246 319625 224674 19386 20969 14422 73699 54613 56398 14430 15587 216558 216019 15442 50917 16548 19052 71951 20970 19053 19139 51792 54371 66171 71797 14735 12505 268512 100043349 71336 445007 231583 53412 75456 19895 235582 212032 21770 14043 14042 15531 226265 15530 77559 110639 13521 27419 73836 56336 56386 13806 103978 18563 235504 74241 66681 54616 16770 58193 80982 14733 21991 53374 83398 50786 69912 17160 13808 77590 13807 108652 103468 93683 13853 68401 231727 20525 14734 116847 234865 20322 319901 64580 117592 67883 59015 59031 69736 57370 53418 21351 56375 215015 110379 26878 26877 54218 50787 270198 18641 73744 18642 26384 12183 14378 14381 18639 14377 18640 170768 102448 18648 56012 14348 15366 21881 70974 15118 15117 15116 17159 56421 72136 110173 58250 18663 54710 628779 235534 667035 225913 22190 67980 50785 232493 14936 74185 27357 74468 110208 74551 11603 16545 233781 217119 227327 67880 14345 231103 53625 14344 14343 93961 11668 15476 72157 15478 27029 195646 17423 14347 280645 18679 56773 110094 102093 72727 234356 232449 27047 58810 11674 72141 230163 20444 20442 20443 INACTIVATION OF CDC42 AND RAC1%REACTOME DATABASE ID RELEASE 96%428543 Inactivation of CDC42 and RAC1 19353 19876 259302 223666 20563 14270 117600 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9025046.2 NTF3 activates NTRK2 (TRKB) signaling 18212 18205 REGULATION OF TBK1, IKKΕ (IKBKE)-MEDIATED ACTIVATION OF IRF3, IRF7%REACTOME%R-HSA-9824878.1 Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 17087 56480 667035 21898 22190 12475 22031 56489 225471 106759 21353 71648 ETHANOL OXIDATION%REACTOME DATABASE ID RELEASE 96%71384 Ethanol oxidation 11529 68738 11522 26876 11532 11669 11668 60525 72535 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 96%9706377 FLT3 signaling by CBL mutants 14256 667035 22190 12402 14255 DEFECTIVE OGG1 LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9657050 Defective OGG1 Localization TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION BY EBF2%REACTOME%R-HSA-9844594.2 Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 216848 12865 17977 19017 107932 70673 22227 12683 12686 94187 19646 234366 116871 12162 51810 116870 13592 20181 19013 245688 17125 19016 17128 23942 17192 433759 170826 15182 229542 SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.6 SUMOylation of immune response proteins 16151 106021 229615 19106 18035 56489 19697 59004 20610 18034 22196 PURINE SALVAGE%REACTOME%R-HSA-74217.7 Purine salvage 75894 18950 229665 15452 109674 11717 105446 11534 11486 11821 66355 13178 27369 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 96%5679096 Defective ABCG5 causes sitosterolemia 67470 27409 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 96%9683701 Translation of Structural Proteins 20448 19089 56637 12330 667035 22190 57377 22196 14423 214424 328417 606496 67287 80285 52552 20446 671535 20444 547253 20442 20443 17308 20440 14376 20447 CA2+ PATHWAY%REACTOME%R-HSA-4086398.5 Ca2+ pathway 233833 18796 18797 14686 21415 18795 14681 12387 16842 57265 14697 12322 14710 14699 26409 66066 14700 16438 16439 22411 14708 14706 14704 14695 16440 14693 64337 14709 14701 76850 239528 14702 14696 236511 21414 21416 14367 14365 14366 22418 213988 217351 214150 14368 14688 640703 19055 17454 19056 18018 19058 225600 18750 19091 19092 18587 18588 18099 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors 22632 328572 12705 17684 70472 12575 11816 18741 332937 18148 233107 12640 75605 21418 12914 13866 110052 80707 17869 13982 13649 21802 21420 15510 110109 21419 22196 106931 16590 22339 56222 17865 226896 64050 DEFECTIVE MAOA CAUSES BRUNS%REACTOME DATABASE ID RELEASE 96%5579012 Defective MAOA causes BRUNS 17161 ALK MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9700645 ALK mutants bind TKIs 14268 18148 67300 78798 268980 13666 215114 12211 19043 19084 14025 11682 PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70688 Proline catabolism 56189 212647 19125 DEPYRIMIDINATION%REACTOME DATABASE ID RELEASE 96%73928 Depyrimidination 319178 319183 319182 232440 319190 57321 319176 319181 17193 234258 71726 319152 382913 18294 21749 72774 497652 18207 21750 319169 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME%R-HSA-168273.5 Influenza Viral RNA Transcription and Replication 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 11545 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 100037258 19386 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 70572 667618 100040970 267019 56040 67248 445007 100040331 67941 57294 69912 103468 234865 59015 69736 110379 68705 98053 667035 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 170762 108989 231042 227699 223921 227720 269113 66679 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 27207 67097 670832 231413 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.3 Endosomal Sorting Complex Required For Transport (ESCRT) 56324 15239 20844 105513 667035 22190 107305 72543 27681 70160 194309 52348 116733 73711 22088 67123 330192 28084 76959 66201 20479 66914 66371 68953 75608 208092 66700 RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME DATABASE ID RELEASE 96%8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 328572 19763 12400 54383 67155 67057 13619 239985 20586 20588 20587 241915 56456 12416 56353 66993 19821 15258 83766 13001 13000 100039026 494448 93760 66923 30951 319974 12418 68094 76073 83796 83797 57376 77044 12151 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.3 Mitochondrial translation elongation 64658 66419 64660 78523 94061 623346 102060 50529 233870 100040519 68565 99045 66973 69163 52443 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 67681 66399 64655 107733 68537 18100 67707 94066 60441 218506 66230 68463 65111 74600 107734 66242 28028 68735 622268 27398 94067 28030 67840 68836 79044 94065 57312 75398 68572 67308 64659 56282 66292 24030 66121 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.5 G1 S DNA Damage Checkpoints 12234 93687 56436 208583 17463 57296 20422 26445 26446 12575 19172 19173 19175 19177 21402 56438 26443 26444 12566 19170 12447 66413 26965 667035 26416 22190 12448 59029 12576 67089 103583 70247 19094 12795 22059 17248 29813 59092 26374 50883 228829 12428 17246 11920 56637 12578 12427 21762 22123 19179 19181 12649 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 12530 23997 27373 TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.3 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 16456 18762 11848 102098 70737 93742 56513 14225 21803 75788 21812 667035 21813 22190 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1SW LOSS OF FUNCTION%REACTOME%R-HSA-9918443.1 Defective visual phototransduction due to OPN1SW loss of function 12057 VIRAL MESSENGER RNA SYNTHESIS%REACTOME%R-HSA-168325.6 Viral Messenger RNA Synthesis 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 68705 98053 66420 69833 67710 245841 69920 20022 69912 20020 231329 20021 103468 69241 17749 100043714 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 96%5621575 CD209 (DC-SIGN) signaling 18747 328572 12914 18481 19697 19698 15896 17096 73086 18176 170786 18749 15461 110157 18033 224105 18479 14360 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME%R-HSA-5624958.4 ARL13B-mediated ciliary trafficking of INPP5E 68146 64436 18582 RHOG GTPASE CYCLE%REACTOME%R-HSA-9013408.2 RHOG GTPase cycle 13511 12389 22324 22319 11855 277360 192662 263406 11857 14570 68813 19349 18805 624814 70584 56418 56384 70361 233103 22325 229658 544963 622434 66251 68202 16412 545156 16443 13726 23943 75739 57257 140579 628438 71782 17207 94176 330662 94190 16709 52331 218581 84004 21917 56491 26403 109904 224105 238130 18708 230972 20430 56419 70804 380664 104445 56389 13836 59079 223666 108037 69922 223435 98386 330914 232906 56212 71435 228359 66508 208869 22042 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.2 Triglyceride metabolism 23945 75497 16890 19045 12389 64899 14732 21884 14626 14933 67469 215456 14245 19046 103968 66905 64898 13350 12140 16204 16592 14077 233549 67800 18747 14571 68393 14079 19047 14080 75772 11770 18749 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866907.3 Activation of the TFAP2 (AP-2) family of transcription factors 12705 12914 328572 332937 17684 80707 56222 21420 21419 226896 64050 21418 SYNTHESIS OF GDP-MANNOSE%REACTOME DATABASE ID RELEASE 96%446205 Synthesis of GDP-mannose 110119 69080 331026 15275 29858 54128 TURBULENT (OSCILLATORY, DISTURBED) FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9860927 Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells 56489 19697 16150 16151 11350 14672 16412 22601 73699 71978 12675 12306 16410 20846 12334 14083 16416 12336 16402 19052 14682 18033 69543 51792 19246 18035 22330 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5688399.4 Defective ABCA3 causes SMDP3 27410 CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.3 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 12539 13649 12402 18176 14388 20662 15461 18803 667035 22190 13645 18708 18706 20416 15519 SIGNALING BY ROBO RECEPTORS%REACTOME DATABASE ID RELEASE 96%376176 Signaling by ROBO receptors 13138 622534 14852 238217 214230 17973 16785 16870 666669 16871 100040021 12767 67025 268902 100043391 326622 668182 13176 241053 18186 20779 16876 432502 19087 238276 19989 20663 76808 67252 19899 12331 100043184 241656 19921 71436 19934 18643 100043755 18645 22323 16872 67031 319195 20564 100043209 20562 68193 15399 621100 19941 665189 666899 100042670 100039316 18747 11350 22121 100043876 100043893 100043423 100042986 20115 67281 20662 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 18479 67248 100040331 67941 57294 18481 68092 433702 76707 14733 192160 208643 19056 67923 21762 22123 60365 19179 19181 19182 23996 19184 68134 26440 19166 76499 19167 26441 192170 26442 19826 69077 66997 23997 66441 56436 17149 17463 57296 20422 11848 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70584 70247 12830 224105 19876 259302 223666 20563 14270 117600 19353 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 18749 20102 268721 20103 11352 668668 14853 667739 17974 16825 16392 20315 672214 170822 54003 66481 71745 225058 17925 100038875 18750 18208 100038991 225363 68028 14026 100043000 17690 67891 18458 100043295 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.4 Synthesis of substrates in N-glycan biosythesis 20448 15275 50935 192156 67311 225742 236082 107652 26938 20451 19703 245847 227697 20445 20449 54342 19025 50798 54613 66174 57357 50877 56174 14583 13480 14584 234730 13481 22122 241230 75540 228368 66248 24060 240119 218138 20454 109785 52014 12764 20450 57170 69064 94181 74091 68563 67422 20452 18010 241159 23956 235504 110119 69080 331026 29858 54128 20446 20444 20442 20443 20440 12091 20447 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.6 Attachment and Entry 15529 11603 23888 20971 20969 15530 14734 50528 70008 18186 171283 103978 269523 71951 18550 20970 14735 14733 ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME%R-HSA-9634638.3 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 20807 13649 21802 12223 16589 71920 103573 11651 12443 14083 13874 11652 13712 15200 56484 11839 12043 14281 13645 12576 26413 26417 23797 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME%R-HSA-209560.3 NF-kB is activated and signals survival 18053 18412 18033 16179 667035 18035 22190 19697 18049 22034 16150 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209905 Catecholamine biosynthesis 13166 18948 21823 13195 CS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022870 CS-GAG biosynthesis 77590 12111 121021 13004 78752 59031 60322 269941 58250 29873 74241 13003 338362 71797 234356 53374 78923 12032 13179 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 96%432720 Lysosome Vesicle Biogenesis 252903 15239 20404 75612 22320 17113 14533 13423 11840 74325 15481 67489 20955 11766 11781 108011 215890 74438 105245 64138 13430 11782 72685 68953 67300 109689 22318 12757 11768 11769 108012 11820 11764 11765 11767 METHYLATION%REACTOME DATABASE ID RELEASE 96%156581 Methylation 22017 67768 108645 13077 57344 67674 238505 11720 232087 210009 14873 269378 18113 12846 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176034.4 Interactions of Tat with host cellular proteins 107951 12455 DEFECTIVE HEXB CAUSES GM2-GANGLIOSIDOSIS 2%REACTOME DATABASE ID RELEASE 96%3656248 Defective HEXB causes GM2-gangliosidosis 2 15212 ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME%R-HSA-392023.4 Adrenaline signalling through Alpha-2 adrenergic receptor 11551 11552 11553 IRS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112399 IRS-mediated signalling 14389 74769 16367 14172 80857 18576 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 327826 18176 14388 20662 15461 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 18607 DEFECTIVE ABCC2 CAUSES DJS%REACTOME%R-HSA-5679001.5 Defective ABCC2 causes DJS 12780 LAMININ INTERACTIONS%REACTOME%R-HSA-3000157.4 Laminin interactions 16412 15530 16775 16776 16777 16779 16780 16410 12822 226519 16782 16772 192897 23928 109700 16773 16398 16774 18074 16400 16403 18073 16404 TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME%R-HSA-9616222.3 Transcriptional regulation of granulopoiesis 328572 319178 319183 319182 12400 232440 20375 12575 319190 319149 211586 13555 21781 16842 319176 12567 12566 319181 14461 15077 21349 14581 16194 14247 12224 110794 12606 12986 214162 20181 110052 17869 319169 12608 20848 625328 78303 19401 15267 319188 15270 319168 319167 17863 624153 319186 382522 ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME%R-HSA-983168.4 Antigen processing: Ubiquitination & Proteasome degradation 20437 99152 636931 668450 328234 76608 19823 227738 74153 22201 79263 22209 74244 53323 140629 68497 70620 330369 23807 140499 59009 17237 50788 22213 67128 433766 22222 224938 22214 17999 98766 67615 19155 268470 67588 59026 107568 230903 66772 208372 76454 70093 329152 117146 65247 22215 65255 67345 81018 84585 67731 217342 142687 209462 78910 231380 65256 70392 69807 76580 244421 22036 224170 240396 225055 24105 232539 56515 170823 215061 67138 19822 74132 67490 231670 672511 226098 69754 224619 77113 14897 59044 12702 207952 70348 320118 170737 70928 56228 30843 68854 76294 211007 72323 399566 30945 68098 100763 214931 67923 106052 242960 30838 30050 50762 56438 50754 213980 68628 50789 30839 22195 50873 16396 56424 218203 93836 26554 211255 71745 22210 66105 56371 27401 80751 66313 107995 21762 22123 19179 19181 19182 23996 19184 75788 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 67089 103583 70247 117589 78541 69299 218215 94090 233902 69116 208650 73998 50760 20821 235320 242521 209239 74492 75234 66799 72194 67845 15204 69706 235439 57751 140630 94091 217194 16924 22019 226541 65257 104184 19820 78913 242785 56791 68729 69010 211949 66743 233040 231672 18744 50492 224826 231863 101358 12449 224023 109161 83814 22193 71538 76375 67455 14794 100041766 217217 216150 71999 269529 93765 83962 66589 230654 635668 240028 66515 269514 78889 68431 230904 28105 71865 380928 50868 207215 22200 627648 207304 75717 70294 67921 100041484 22192 66663 142688 217232 243574 56317 321006 59008 268291 209200 66156 74646 216080 448987 69957 22346 17222 56736 228003 68612 52563 12703 22194 212919 71393 68999 54484 52206 20439 100039535 218793 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME%R-HSA-390471.3 Association of TriC CCT with target proteins during biosynthesis 12469 12461 14466 12464 30050 50762 24128 50754 12447 216853 12448 15183 108077 27055 71833 14447 213980 68628 22059 12465 16553 55946 50789 20848 30839 12466 67134 21454 12462 20698 99371 106052 66887 242960 12467 30838 12468 DEGRADATION OF CRY AND PER PROTEINS%REACTOME%R-HSA-9932298.1 Degradation of CRY and PER proteins 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 18626 67089 18627 103583 18628 70247 12953 12952 21762 22123 50789 19179 19181 19182 23996 19184 26440 19166 216080 19167 26441 26442 69077 66997 23997 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622327 Postsynaptic nicotinic acetylcholine receptors 11438 110834 11449 110902 11435 11448 11447 11440 108015 108043 11444 110835 231252 MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 96%8874081 MET activates PTK2 signaling 16412 16775 16776 20779 16777 16779 16780 17295 15234 226519 14083 16782 16772 23928 16773 16398 16774 16400 SARS-COV-2 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9705677 SARS-CoV-2 targets PDZ proteins in cell-cell junction 224912 14609 56217 12695 21872 FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190241 FGFR2 ligand binding and activation 14172 80857 14180 14178 14177 67112 64654 14175 14174 14173 14164 14181 72514 80903 14165 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME%R-HSA-5579006.4 Defective GSS causes GSS deficiency 14854 SIGNALING BY TCF7L2 MUTANTS%REACTOME%R-HSA-5339700.5 Signaling by TCF7L2 mutants 13017 13016 21416 RAC3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013423 RAC3 GTPase cycle 106952 71893 26934 16449 110279 330177 75409 105855 242687 216963 386750 17969 20947 212285 237038 13511 70497 12389 320634 11308 22319 20619 11855 224480 277360 11856 107746 13058 241275 11857 13057 108100 76117 19349 218952 26431 17970 70584 101314 56418 17972 66898 70361 71302 233103 22325 71544 229658 16412 13726 23943 75739 94190 52331 218581 84004 21917 109904 224105 18708 18709 20430 18479 56419 70804 380664 104445 13836 59079 223666 69922 14270 223435 98386 330914 232906 71435 228359 20514 66508 21844 11352 105827 195727 210293 50884 71709 83767 22042 170758 329165 109934 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME DATABASE ID RELEASE 96%8949275 RUNX3 Regulates Immune Response and Cell Migration 20750 16401 12400 16408 12399 DISEASES OF PROGRAMMED CELL DEATH%REACTOME%R-HSA-9645723.8 Diseases of programmed cell death 14103 12532 12380 74568 12333 232440 13626 319149 15077 52615 19646 18969 18968 13436 13435 13433 245688 19075 19076 12261 22059 15267 319168 319167 12370 19766 319186 56532 319178 319183 319182 22030 319190 319176 319181 54722 71609 14082 12578 14056 319169 12334 12336 20656 56484 625328 16476 78303 69543 319188 18477 15270 21672 16906 22627 12569 12568 11820 624153 99412 12125 12530 12531 382522 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674396.2 Imatinib-resistant PDGFR mutants 18595 DIGESTION AND ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963743 Digestion and absorption 14917 11722 76768 12613 14916 69060 20537 18946 20526 109791 56485 18947 58866 69983 67717 232714 69656 14915 81600 71884 226413 100043686 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME%R-HSA-76042.5 RNA Polymerase II Transcription Initiation And Promoter Clearance 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.5 PLCG1 events in ERBB2 signaling 13866 18803 13649 13645 NEURODEGENERATIVE DISEASES%REACTOME%R-HSA-8863678.3 Neurodegenerative Diseases 14103 12532 12380 12333 12334 12336 20656 56484 16476 69543 18477 21672 16906 22627 12569 12568 11820 99412 12125 12530 12531 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME DATABASE ID RELEASE 96%5619045 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) 20531 DEFECTIVE NEUROTRANSMITTER CLEARANCE BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME DATABASE ID RELEASE 96%5619081 Defective neurotransmitter clearance by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) 13162 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 18011 232232 13388 16449 240055 225164 20602 11487 54485 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 15213 56233 17869 15214 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 15205 19664 433759 15182 DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.4 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) 18400 PLUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164525.3 Plus-strand DNA synthesis 268373 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.3 The role of Nef in HIV-1 replication and disease pathogenesis 252903 12487 19353 11771 11772 71770 11840 14360 108664 232910 11773 12504 94176 15162 15007 16818 12526 12010 11768 224105 140580 11769 108012 11764 107975 11765 11767 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%191273 Cholesterol biosynthesis 73166 13595 15490 110196 14137 98386 100040592 235293 68603 20775 192156 13121 20788 13360 14593 16987 319554 17855 20787 74411 74754 66234 18194 110460 68865 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1MW LOSS OF FUNCTION%REACTOME%R-HSA-9918436.1 Defective visual phototransduction due to OPN1MW loss of function BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME%R-HSA-9026766.2 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) 17001 BIOFILM FORMATION%REACTOME DATABASE ID RELEASE 96%9931953 Biofilm formation 109637 17075 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.8 Transcriptional Regulation by TP53 233833 12534 22628 11651 60599 11652 67338 20620 26416 66214 19646 234366 240087 77976 13001 13000 100039026 17988 19094 234594 245688 382985 54401 55948 14751 23942 78757 50493 104625 108099 108083 18607 328572 15257 18983 270627 228980 319944 21374 20922 59035 20833 71361 216185 108143 66464 68776 14776 99730 70439 67655 20869 21399 64930 107951 57314 114741 66508 15258 72504 545987 21343 209361 12914 226182 12454 54170 75747 11909 24074 22084 52187 58202 68576 66096 83409 12857 67923 74370 27224 68441 27632 12450 24116 268706 12455 69131 72949 13716 63856 245670 53621 110323 16476 72068 18477 12861 21672 232791 19650 22627 12569 19651 12568 12862 12868 66142 216848 12532 12866 12865 100041785 208836 107932 12662 72119 18148 53376 19211 333182 68428 216456 66494 100039786 26992 22059 68742 14102 12362 380975 268936 229542 670717 23988 21933 17992 69076 18718 22061 12028 226830 244349 74747 11783 69562 20393 12575 18854 211586 13555 21781 12566 12447 13163 12448 12576 80751 73699 11799 69181 19052 17192 77683 19053 51792 20877 22166 21981 228140 17248 17165 70088 26931 13496 53325 69125 12428 17246 209456 219024 110147 26399 219103 66813 22062 319801 58184 52679 12578 104394 241764 12858 12427 107986 13197 57748 14660 67956 268973 230784 20463 76367 69260 18861 14381 17685 17350 78893 225655 52846 231464 68705 98053 27374 667035 13871 22190 66420 69833 64058 67710 245841 69920 20022 14885 209357 66467 20020 17708 231329 17709 20021 17710 69241 66671 17749 12795 100043714 17420 12572 13872 20924 23894 14884 57913 12366 12368 14281 19360 17535 12053 76850 21975 239528 19364 84682 27354 12021 29813 59092 81601 50883 56187 327762 228829 236511 19352 241113 22427 56717 333654 19718 69263 15574 11920 16009 12189 213988 235610 231724 12227 237911 217351 19355 12122 214150 66262 225182 12142 227743 26909 18538 235559 12144 68275 106344 78783 72151 211651 14088 68240 17454 252870 19891 15469 109270 22631 12177 19367 19356 105787 22629 108079 20878 19079 12649 108961 108097 18996 18997 433759 12905 219022 19082 56716 15182 23797 RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 96%110381 Resolution of AP sites via the single-nucleotide replacement pathway 18970 11792 22594 16882 REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.5 Regulation of TP53 Activity 12534 20393 18854 11651 60599 12566 11652 67338 26416 13163 19646 234366 80751 77976 13001 13000 100039026 19094 245688 73699 69181 23942 19052 17192 77683 78757 19053 51792 20877 21981 108099 108083 18607 17248 328572 17165 15257 70088 26931 53325 12428 17246 209456 219024 110147 270627 26399 228980 319944 21374 20833 22062 216185 108143 66464 68776 99730 70439 20869 114741 72504 15258 21343 209361 12578 226182 241764 24074 12427 12450 57748 63856 67956 12569 12568 76367 69260 216848 107932 72119 27374 53376 667035 22190 12795 26992 22059 19360 17535 21975 268936 229542 27354 12021 29813 81601 50883 23988 327762 228829 241113 22427 333654 56717 19718 69263 18718 15574 11920 22061 12189 235610 231724 237911 19355 226830 66262 225182 12142 227743 26909 235559 12144 244349 68275 106344 78783 72151 68240 252870 19891 109270 19367 19356 105787 108079 20878 19079 12649 18996 108097 18997 433759 219022 19082 56716 15182 23797 LEISHMANIA INFECTION%REACTOME%R-HSA-9658195.3 Leishmania infection 17913 13479 58861 246256 17973 14131 17909 66824 330319 216799 76884 12495 19087 19084 22612 22324 217344 20620 93671 16153 17886 26416 12928 26413 229709 26417 14360 16438 16439 18747 22325 11350 16440 12502 57257 17096 11465 22166 15516 15368 18550 16193 640703 26419 16476 18033 18803 50884 83767 329165 71893 105855 11491 242687 19697 237038 11308 14697 241275 13057 108100 11461 14710 14699 66066 14700 101314 14708 14706 12266 14704 14695 14693 140579 64337 14709 16176 330662 12362 14701 15162 56338 140580 20430 14702 16173 14696 19088 234779 69146 17918 19108 12499 18034 12267 76709 73178 19353 104110 22418 20963 16175 14678 14677 12229 56443 14687 19200 14679 432530 210044 14369 104111 80987 68089 14688 67771 11867 54483 56378 18438 66713 74117 13542 70086 224129 245880 11512 11513 11514 11515 14191 18749 13544 14083 13543 22376 215280 14598 18439 319446 68524 67955 13035 11541 23959 17925 23887 17882 14129 242851 19085 INTESTINAL LIPID ABSORPTION%REACTOME%R-HSA-8963678.3 Intestinal lipid absorption REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.3 Regulation of PTEN stability and activity 56436 17463 57296 20422 26445 26446 19172 19173 19175 66894 19177 72607 68031 73162 26443 11651 19720 26444 11652 21951 74493 19170 14302 66413 667035 19211 22190 59029 17999 67089 70247 13001 13000 100039026 56424 11798 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 54484 23797 66997 23997 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.2 Acetylcholine inhibits contraction of outer hair cells 16531 16533 140492 504186 231252 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME%R-HSA-5358565.3 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 17685 68275 17350 17688 18971 68240 18972 19891 67967 16881 69745 26909 18538 18861 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.5 Sialic acid metabolism 94181 20448 74091 20452 18010 241159 23956 50935 235504 67311 225742 26938 20451 20445 20449 19025 50798 54613 50877 241230 20446 20444 24060 20442 240119 20443 20454 20440 12764 20450 12091 20447 STAT3 NUCLEAR EVENTS DOWNSTREAM OF ALK SIGNALING%REACTOME%R-HSA-9701898.3 STAT3 nuclear events downstream of ALK signaling 328572 20848 60533 13433 433759 16186 12142 15182 15183 15251 20466 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855204 Synthesis of IP3 and IP4 in the cytosol 18796 18797 18795 234779 320634 19211 269437 104015 16330 16331 16332 269615 18798 18799 72469 18802 217837 640703 228550 74055 320404 114875 104759 233011 18803 OLEOYL-PHE METABOLISM%REACTOME DATABASE ID RELEASE 96%9673163 Oleoyl-phe metabolism 212933 EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 96%9648025 EML4 and NUDC in mitotic spindle formation 78798 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 59125 59126 12235 217718 67037 68097 16319 19052 73804 19053 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 18817 110379 69928 13427 76499 13426 52504 13424 228421 PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME DATABASE ID RELEASE 96%427975 Proton oligopeptide cotransporters 65221 56643 100561 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.5 MPS IIIB - Sanfilippo syndrome B 27419 FERTILIZATION%REACTOME%R-HSA-1187000.4 Fertilization 212670 271036 71564 14595 12527 22787 329954 71078 11434 22788 22786 16532 106757 225865 74096 73456 12659 320225 56622 74468 76856 75510 11495 NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.10 Neurotransmitter receptors and postsynaptic signal transmission 18796 18797 18795 12326 14811 18039 14810 11472 20779 320472 19087 19084 23859 238276 14814 68606 52163 14813 12322 12323 108058 12325 26413 26417 18747 100039592 110651 18176 20112 15461 17920 108099 18607 53623 14799 57014 17246 110304 14680 243547 16559 14802 55984 19417 19418 18693 16519 16520 54393 211323 16518 15561 22343 16516 14402 14401 14400 14399 110886 14800 14397 14396 14395 14394 16521 11438 16522 110834 16524 11449 16513 640703 110902 16515 11435 54377 11448 21912 11447 14409 11440 74053 108015 14408 108043 18195 11444 14407 110835 14406 14812 231252 16517 108030 64011 207565 57249 12300 54376 18752 12361 81905 14658 237213 14654 328699 319924 67071 170483 236915 22342 242425 216963 14697 18751 14710 14699 66066 14700 14708 14706 110637 14704 14807 14806 14695 13385 14805 52589 53310 14693 13383 14809 64337 14709 14701 14702 14696 241113 19088 19108 19353 104110 11771 14678 14677 14679 432530 210044 104111 14688 20111 224129 11512 11513 105787 11514 108079 11515 19079 18749 108097 19082 18750 242851 19085 REGULATION OF BETA-CELL DEVELOPMENT%REACTOME%R-HSA-186712.4 Regulation of beta-cell development 328572 246086 19213 18508 21410 16334 21405 11925 18088 18096 56458 15376 18012 18609 18128 333639 15379 378435 11651 15377 11652 320995 270118 53626 103988 12914 14534 18519 20526 15205 15874 19664 30942 103806 23797 14165 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 96%209543 p75NTR recruits signalling complexes 18759 192656 18053 17874 18412 16179 667035 22190 18049 22034 16150 ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2485179.4 Activation of the phototransduction cascade 14685 20215 12788 214111 212541 225600 14699 18587 18588 14688 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%975871 MyD88 cascade initiated on plasma membrane 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 71481 667035 26416 211550 22190 17258 20203 26410 26409 20210 24110 26413 103583 257632 26417 26940 266632 26401 80750 223664 53791 107607 19094 69721 102626 231130 93834 270151 73699 11596 26395 67454 22059 240518 71966 110651 108960 20112 59025 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 12370 21770 22030 67245 26399 26400 18034 26398 26420 13712 26414 26397 17260 434174 66513 93765 66589 23939 22034 66724 68652 20111 11909 26419 12675 16476 18033 18035 18036 11820 RORA,B,C AND NR1D1 (REV-ERBA) REGULATE GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9933387 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression 328572 12914 20181 56406 19013 21372 109151 19883 17977 19017 17978 59035 81004 66993 12894 20787 268903 19014 19885 229003 15183 20185 217166 SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 96%9669933 Signaling by kinase domain mutants of KIT 16590 DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.5 Defective pyroptosis 319178 319183 319182 232440 13626 319190 319149 319176 319181 15077 54722 52615 19646 18969 18968 14056 13436 13435 245688 13433 19075 19076 319169 625328 15267 78303 319188 319168 15270 319167 624153 319186 382522 SIGNALING BY BRAF AND RAF1 FUSIONS%REACTOME%R-HSA-6802952.3 Signaling by BRAF and RAF1 fusions 74244 20779 12322 12323 109880 108058 12325 26413 26417 12988 109905 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 11836 26372 109689 56463 216869 26936 21848 11774 330286 16452 67726 110135 100986 99571 78781 22330 19317 16706 11610 76156 210106 66549 16905 67095 14359 69923 338523 640703 17169 23971 12125 ASSEMBLY OF THE 9+0 PRIMARY CILIUM%REACTOME%R-HSA-9975921.1 Assembly of the 9+0 primary cilium 20873 68121 76260 81896 12534 69940 78887 16570 71769 107338 21821 22628 76411 277939 225745 241950 231123 66482 654470 67590 74360 73242 238799 18536 109181 13196 68259 66296 214552 59030 74201 18541 76568 75786 66061 15519 16568 18747 213081 213575 67161 19889 53869 71909 140810 237222 52028 67378 93730 102774 74025 17997 12879 68097 67978 264134 18005 215445 73738 68475 51792 53598 208518 67694 380718 100041639 67286 236266 20607 78802 106633 244585 12009 99100 103733 319845 22154 74470 104318 56455 101565 110350 16559 16328 219103 18763 18764 260305 76779 16579 83922 71492 245866 216363 26370 76707 13589 18472 232987 21454 12462 13427 22627 13424 27373 12469 12461 12464 64436 18582 227613 68146 22153 22142 212541 22145 12465 100986 319757 12589 19088 56350 77048 230376 69654 52906 17274 18000 73668 67661 75296 53413 75465 15185 72421 72140 106840 67344 67068 219072 11843 20336 56297 225659 107371 72938 53885 207911 76478 320299 329795 78177 16569 217935 27078 28135 214444 76816 74019 217335 54130 105504 74682 211446 72569 18817 71820 381644 102058 109242 67042 233649 73916 12789 382090 232944 231214 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME DATABASE ID RELEASE 96%76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 21374 67065 71752 74414 233863 66420 72308 69833 66596 78929 245841 544971 70239 269252 26939 67486 70408 20018 69870 70428 67371 17749 218832 100043714 67005 20016 98488 12909 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME DATABASE ID RELEASE 96%8941284 RUNX2 regulates chondrocyte maturation 16147 12400 208727 14633 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 96%6811440 Retrograde transport at the Trans-Golgi-Network 17957 67542 78689 242406 56382 53330 228960 69834 224705 76899 245944 97484 68505 233824 54214 232286 68299 22319 227746 70297 66905 17113 76932 18195 73296 108123 108124 16004 74375 76332 16834 226089 76688 270192 53611 56367 319642 102339 19346 98910 58244 70646 78304 338337 104303 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME%R-HSA-2393930.8 Phosphate bond hydrolysis by NUDT proteins 214254 53893 66358 75686 RNA POLYMERASE II PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73776 RNA Polymerase II Promoter Escape 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6782315 tRNA modification in the nucleus and cytosol 107508 108943 328162 233189 240174 76357 74455 229780 66965 209584 68736 30947 13434 100929 54632 68260 73681 68916 66966 28114 66369 67049 57773 17299 100043886 66757 67674 106248 68205 66628 66246 212528 69786 329504 60507 67667 78890 319582 78697 76367 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 96%430116 GP1b-IX-V activation signalling 110157 14723 22631 18708 14724 192176 54368 14729 22371 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 96%430039 mRNA decay by 5' to 3' exoribonuclease 67678 234699 24127 66094 13209 319618 67207 70640 75901 78651 27756 353190 225929 66373 50783 CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME%R-HSA-5620920.6 Cargo trafficking to the periciliary membrane 12469 76260 12461 69940 12464 71769 107338 241950 64436 18582 66482 68146 73242 13196 212541 59030 19889 53869 52028 67378 93730 12465 102774 74025 12879 215445 20607 319757 319845 56350 18763 18764 17274 71492 216363 53413 15185 106840 11843 20336 56297 107371 207911 105504 211446 72569 21454 12462 102058 233649 12789 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME DATABASE ID RELEASE 96%174113 SCF-beta-TrCP mediated degradation of Emi1 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 26443 67141 26444 107995 19170 66413 26965 56371 667035 22190 59029 67089 70247 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME DATABASE ID RELEASE 96%9702518 STAT5 activation downstream of FLT3 ITD mutants 14389 20850 18712 50490 14784 12575 12048 14255 19247 20851 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME%R-HSA-2142816.3 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) 71519 106648 100040843 13078 72303 107141 13077 13076 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9018519.3 Estrogen-dependent gene expression 22632 233833 232440 319149 16478 12443 15077 12005 15519 100039592 17869 21802 20842 24061 19014 15516 19357 328572 12400 17977 14462 21374 17978 59035 268903 107951 13006 12914 235459 11909 83602 12455 16476 12043 17863 20843 20683 14732 68705 98053 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 13982 17749 100043714 15267 319168 18667 319167 14281 76850 239528 319186 319178 12705 319183 319182 81601 236511 319190 14282 319176 319181 213988 217351 214150 67393 12648 13033 99982 14228 18986 17979 193796 228913 13207 21887 15375 55960 268527 107351 17454 26424 21786 15469 319169 22282 22278 18519 100041004 100043508 625328 78303 319188 15270 433759 20315 624153 71393 382522 L1CAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373760 L1CAM interactions 235281 56613 74947 20266 20265 13004 12805 11733 11735 14432 640524 18186 20742 20741 319504 73086 20743 20404 26394 20271 399548 20272 20274 20273 109700 103967 16398 11658 110876 53321 20269 72821 110880 22350 17967 26413 269116 26417 71653 80297 20264 22325 213119 13001 56705 13000 100039026 16412 13649 13385 53310 26395 13383 26396 16777 110651 20112 16399 226519 16416 16402 16772 18479 19353 53378 11771 11772 71770 15481 20111 232910 11773 13430 18222 16571 16410 21367 53870 24046 13844 16728 12661 18187 67300 13429 13193 12757 19684 12934 16536 17698 110862 67071 104099 20739 20740 SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 96%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 20492 72290 116748 20638 384091 666609 243963 68092 67332 433702 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-1912408.8 Pre-NOTCH Transcription and Translation 233833 232440 319149 211586 18129 13555 18131 18128 21781 18132 12443 270118 18759 15077 13557 50721 13710 22059 15267 319168 319167 76850 103806 239528 319186 328572 319178 319183 319182 236511 319190 333639 319176 50701 319181 213988 217351 214150 12914 17454 14534 319169 18519 625328 19664 16476 78303 319188 15270 624153 382522 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME%R-HSA-5654687.4 Downstream signaling of activated FGFR1 327826 80857 14180 399558 396184 14177 67112 64654 14175 18176 14174 14388 20662 14173 14164 15461 71436 107971 18803 18708 19247 14165 18706 DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702506 Drug resistance of FLT3 mutants 14255 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.3 Beta oxidation of myristoyl-CoA to lauroyl-CoA 97212 11363 231086 REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.5 Regulation of TP53 Activity through Acetylation 216848 328572 70088 23988 18854 219024 26399 107932 18718 11651 11652 66262 19646 234366 244349 78783 245688 26992 22059 23942 17192 433759 15182 268936 229542 23797 69260 108083 SIGNALING BY FGFR2 IIIA TM%REACTOME%R-HSA-8851708.2 Signaling by FGFR2 IIIa TM 20020 231329 20021 69241 17749 100043714 68092 14183 14173 433702 14164 68705 98053 66420 69833 67710 245841 69920 20022 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112315 Transmission across Chemical Synapses 18796 18797 18795 17161 12326 14811 18039 14810 11472 20779 320472 23859 19084 14814 68606 52163 14813 26413 26417 18176 15461 17920 108099 18607 14800 11438 110834 11449 110902 640703 11435 11448 11447 11440 108015 108043 11444 110835 231252 22318 20614 20979 20907 216963 63993 14697 14710 14699 66066 14700 216456 14708 14706 110637 14704 14807 14806 14695 13385 14805 52589 53310 14693 13383 14809 13162 64337 14709 14701 14702 14696 19088 19108 11771 104110 14678 14677 14679 432530 210044 104111 14688 224129 11512 11513 11514 11515 18749 14415 14417 242851 19085 19087 238276 12322 12323 108058 12325 18747 100039592 110651 20112 12038 268860 12647 11423 67111 22348 214579 27204 19339 13002 20965 20964 68507 327814 12889 22249 791260 15567 12286 12287 12290 53623 232333 14799 14412 57014 56808 17246 110304 12293 14680 12295 243547 12296 16559 12297 14802 12298 55984 243616 19417 233977 19418 14645 18693 214084 16519 20508 16520 65106 54393 20518 211323 20517 16518 12294 15561 22343 16516 14402 14401 14400 14399 110886 14397 14396 15481 14395 14394 16521 16522 16524 16513 16515 54377 21912 14409 74053 14408 18195 14407 14406 14812 16517 108030 64011 207565 14660 57249 12300 54376 18752 12361 12846 81905 14658 237213 14654 328699 319924 67071 170483 236915 22342 242425 18751 241113 242607 14411 67760 19353 20513 11669 20511 20510 20512 20111 105727 105787 108079 19079 108097 19082 18750 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.2 Global Genome Nucleotide Excision Repair (GG-NER) 22632 56438 70620 11545 667035 13871 16881 22190 11461 14885 209357 66467 56469 66671 17420 12572 13872 20610 23894 14884 22196 100043429 12848 229615 27015 69745 100043806 26891 59001 22594 26754 16882 19687 19718 56456 69263 66979 26370 77593 56505 68058 225280 26893 56249 93765 69714 93836 227195 18538 109275 26894 68142 11546 13870 68275 108679 106344 233875 72151 70020 18971 19358 68240 19359 18972 235134 22590 19891 22591 107986 18973 26572 18974 22592 50505 26895 67967 99375 72584 13194 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 96%73929 Base-Excision Repair, AP Site Formation 319178 319183 319182 232440 319190 57321 319176 319181 17193 234258 71726 319152 382913 18294 21749 72774 497652 18207 21750 319169 268395 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 KETONE BODY METABOLISM%REACTOME%R-HSA-74182.6 Ketone body metabolism 69772 208982 110446 15360 78894 71911 15356 67041 64059 MELANIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%5662702 Melanin biosynthesis 13190 22293 18431 22173 22178 DNA REPLICATION%REACTOME%R-HSA-69306.9 DNA Replication 52717 99152 668450 232440 319149 12566 15077 12447 56371 27401 16881 12448 12545 16211 12428 109145 17216 272551 17215 17217 17218 17219 17220 78833 12544 69270 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 226153 69077 19819 66997 50776 23997 18975 216151 56436 27214 17463 67177 57296 23834 74528 20422 208194 26445 14156 26446 57441 19172 70024 19173 381760 19175 16650 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18969 18968 19075 19076 15267 319168 319167 69745 21975 319186 319178 319183 319182 327762 59001 319190 16646 19687 19718 319176 69263 319181 66979 50793 18392 18393 66634 26428 26429 56452 18538 68275 106344 72151 18971 68240 18972 19891 18973 319169 18974 67967 217232 56317 625328 59008 78303 319188 66156 15270 216080 69957 17222 75430 68612 52563 624153 22194 68999 52206 100039535 382522 DRUG RESISTANCE OF KIT MUTANTS%REACTOME%R-HSA-9669937.3 Drug resistance of KIT mutants 16590 ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME%R-HSA-72662.5 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 16785 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 100039316 20115 76846 100040298 13665 67204 267019 26905 67941 57294 75705 27207 67097 13685 670832 13684 633683 20044 27050 208643 667279 20085 668144 20084 382492 20055 75617 27370 629957 20102 20103 668668 667739 66481 225058 100038875 18458 GSD 0%REACTOME%R-HSA-3858516.4 GSD 0 232493 FRS-MEDIATED FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654693 FRS-mediated FGFR1 signaling 327826 80857 14180 14177 67112 64654 14175 18176 14174 20662 14173 14164 15461 107971 19247 14165 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5693567 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) 70620 12566 16881 240087 11350 50721 19822 12428 319152 13870 12427 50505 20422 667035 22190 107823 68251 20184 66131 269582 232314 70681 70238 27223 19365 56420 107976 210766 21853 59004 22196 100043429 15204 52864 19360 27015 69745 17535 21975 19363 319186 19364 27354 319178 12021 319183 224008 319182 60530 81601 327762 269400 59001 319190 19361 114714 209334 22427 19687 19718 69263 15574 11920 319181 66979 12189 12190 235610 231724 237911 19355 57434 225182 74335 93765 26909 18538 235559 71711 12144 381306 68275 106344 72151 18971 68240 18972 233826 19891 18973 18974 80905 19367 19356 19362 67967 268465 12649 78303 319188 15270 382522 EXPRESSION OF BMAL (ARNTL), CLOCK, AND NPAS2%REACTOME DATABASE ID RELEASE 96%9931509 Expression of BMAL (ARNTL), CLOCK, and NPAS2 328572 21372 109151 17977 19017 18143 17978 59035 81004 66993 17260 17261 12753 268903 19885 70461 15183 20185 225998 93759 217166 74343 12914 20181 382056 56406 19013 11909 19883 19014 229003 11865 19377 PLC BETA MEDIATED EVENTS%REACTOME%R-HSA-112043.3 PLC beta mediated events 18796 18797 18795 12326 19088 14675 55984 19108 19087 19084 104110 12322 12323 108058 12325 432530 210044 26413 104111 229709 16438 16439 18798 18747 14672 100039592 640703 224129 14676 16440 18753 11512 18783 11513 110355 11514 18575 11515 18574 18573 18749 207565 14682 18752 18750 19085 RMTS METHYLATE HISTONE ARGININES%REACTOME%R-HSA-3214858.4 RMTs methylate histone arginines 232440 319149 67155 239985 20586 20588 20587 319176 12567 56456 12443 15077 59035 66993 99890 140858 27374 70465 83766 667279 13435 93760 245688 66923 15469 319169 71974 621893 68094 214572 83796 319162 83797 15267 319173 57376 319163 319168 66423 15270 319167 624153 16452 77044 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 96%9665244 Resistance of ERBB2 KD mutants to sapitinib 13866 59079 12539 15519 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.4 Signaling by TGF-beta Receptor Complex in Cancer 21803 21812 21813 17126 14225 17127 17128 TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME DATABASE ID RELEASE 96%1679131 Trafficking and processing of endosomal TLR 13038 170743 13039 13040 19141 170744 13030 22027 54445 142980 81897 INITIAL TRIGGERING OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166663 Initial triggering of complement 317677 14134 14962 12263 17195 12266 12944 625018 11537 16904 12259 71693 12260 12262 667277 239447 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-HSA-74751.5 Insulin receptor signalling cascade 14389 74769 16367 14172 80857 18576 16334 14170 225326 14180 14178 14177 14783 67112 16337 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 26413 26417 20416 327826 18176 14388 20662 15461 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 18607 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 96%9665249 Resistance of ERBB2 KD mutants to afatinib 13866 59079 12539 15519 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-HSA-1834949.6 Cytosolic sensors of pathogen-associated DNA 56480 12387 446099 54131 207521 58203 19697 16150 16151 17874 667035 22190 66420 69833 245841 69721 17749 100043714 20821 71966 69807 17535 142980 19766 56532 328572 106759 19090 384309 18034 22040 383619 72162 72935 72512 54123 67065 20852 268857 74414 22596 13211 14375 214763 78929 26939 67486 70408 12914 20018 69870 70428 218832 67005 20016 12909 12675 18033 18035 18036 REGULATION OF PD-L1(CD274) POST-TRANSLATIONAL MODIFICATION%REACTOME%R-HSA-9909615.2 Regulation of PD-L1(CD274) Post-translational modification 12234 56436 17463 16451 57296 20422 26445 13200 26446 19172 19173 72297 19175 22628 19177 21402 56438 12567 26443 12443 26444 19170 269523 66413 26965 667035 22190 18566 59029 67089 70247 13001 13000 100039026 20747 244373 18005 60533 76580 108099 226144 66357 193670 54197 26754 241113 70377 216440 20014 103963 56637 69038 13135 66753 67819 26554 116891 20338 21762 67075 22123 105787 108079 19179 19079 19181 19182 108097 23996 19184 26440 19166 58205 19167 19082 80286 26441 26442 68292 69077 66997 16430 23997 COPII-MEDIATED VESICLE TRANSPORT%REACTOME DATABASE ID RELEASE 96%204005 COPII-mediated vesicle transport 17957 193813 12068 317717 56494 60409 89867 235416 216131 66397 67231 66890 69608 218811 99683 56418 70361 77371 20334 21802 12836 56389 14799 104318 67091 20703 66226 19324 105522 243819 14067 69162 14275 12793 67857 100042773 20333 215474 64138 207352 74498 66682 18195 52036 108123 76983 108124 13032 245828 12794 240667 67727 214895 59005 14069 110379 78232 56041 11839 333883 21787 27096 72978 227648 99412 76308 76510 100042343 50907 MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702600 midostaurin-resistant FLT3 mutants 14255 INTERACTION OF NURD COMPLEXES WITH TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9940951 Interaction of NuRD complexes with transcription factors 216848 14377 232440 319149 13445 269610 106795 107932 22780 22779 78266 228880 15077 52004 17191 233410 11819 22778 622675 70998 14121 19646 234366 245688 23942 17192 15267 319168 319167 229542 319186 319178 319183 319182 319190 319176 319181 116871 22026 116870 319169 625328 78303 319188 15270 433759 15182 624153 18534 382522 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME DATABASE ID RELEASE 96%5579030 Defective CYP19A1 causes AEXS 13075 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.4 Effects of PIP2 hydrolysis 23945 22065 22068 18754 18755 320127 18761 76192 104418 16438 19395 56077 16439 66082 231871 380921 110524 269060 110197 217480 13139 331374 26946 19419 16440 18753 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.2 Loss of phosphorylation of MECP2 at T308 18747 640703 12326 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 96%5658623 FGFRL1 modulation of FGFR1 signaling 14172 116701 114715 67112 114716 64654 14175 14174 14165 14173 RELAXIN RECEPTORS%REACTOME DATABASE ID RELEASE 96%444821 Relaxin receptors 23919 140498 212108 19773 242093 381489 239336 16336 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%9675136 Diseases of DNA Double-Strand Break Repair 12021 81601 327762 20422 19361 114714 22427 19718 69263 15574 11920 12189 12190 235610 231724 237911 19355 57434 225182 26909 235559 12144 68275 106344 72151 68240 233826 19891 19367 19356 19362 19360 17535 21975 19363 19364 27354 RHOB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013026 RHOB GTPase cycle 26934 110279 21873 12389 22319 20619 11855 277360 14570 71302 22325 229658 19877 17207 52666 16800 94190 263803 52428 14251 13605 218581 270163 84004 20166 236920 19878 13830 109904 16480 18708 68743 18709 20874 213498 56419 12704 243362 110596 207212 19285 14252 59079 71704 223666 234094 11464 330914 50768 232906 56349 54216 71435 16801 228359 11852 404710 13367 75547 20868 268301 320795 109333 72754 208846 69632 17925 22042 109934 ACTIVATION OF RAC1%REACTOME DATABASE ID RELEASE 96%428540 Activation of RAC1 19876 214230 17973 20563 18481 20663 20662 19353 241656 17974 224105 70584 18479 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.7 G alpha (12 13) signalling events 11848 102098 20663 22324 14697 277360 14710 14699 66066 14700 22325 14708 14706 622434 14704 545156 14695 16443 14693 57257 64337 19877 20662 14709 17207 16800 14701 13605 19878 109904 230972 213498 207212 14702 71704 234094 223435 14696 56349 16801 11852 19418 75547 72754 69632 12229 213649 24001 224014 230098 53972 30938 21390 77669 442801 226970 235611 14688 54126 101497 14673 269608 328967 14163 26382 268739 14674 73341 11550 11853 11548 11549 21844 236915 109934 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.6 Beta-oxidation of very long chain fatty acids 11666 26458 15488 113868 170789 26378 74147 171282 SIGNALING BY PDGFR IN DISEASE%REACTOME%R-HSA-9671555.4 Signaling by PDGFR in disease 74769 107351 268980 18595 18176 20846 54214 20662 20848 15461 16542 66899 14011 668218 18708 18709 18706 67561 S PHASE%REACTOME DATABASE ID RELEASE 96%69242 S Phase 52717 99152 668450 17187 12575 211586 13555 19645 21781 12567 12443 11651 12566 11652 12447 56371 27401 16881 12448 12576 19646 17869 218914 20842 24061 19357 12428 109145 17216 272551 17215 17217 100710 17218 17219 17220 78833 12544 69270 67849 13006 13559 104394 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 71521 26441 19651 63955 22390 26442 72568 69077 77805 20843 66997 12530 231506 23997 12531 629959 54124 56436 20459 17463 67177 75660 57296 23834 71988 20422 26445 14156 26446 57441 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18969 18968 66671 19075 19076 17420 12572 69745 327762 59001 19687 19718 69263 66979 50793 18392 18393 66634 26428 56637 26429 56452 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 67967 217232 56317 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 23797 52206 100039535 AMINE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375280 Amine ligand-binding receptors 11554 11555 11556 15560 15559 15558 213788 15557 13492 382348 13491 13490 13489 13488 111174 215855 503558 215854 12672 12671 15552 15466 15551 15550 243764 12669 15465 99296 18241 209512 15566 15565 15563 15562 225192 11550 11548 11549 11551 11552 11553 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 96%5693532 DNA Double-Strand Break Repair 70620 12566 11545 16881 240087 11350 100039592 50721 19822 12428 319152 11546 13870 26419 12427 50505 20422 14156 667035 22190 107823 68251 20184 66131 269582 232314 70681 70238 27223 19365 56420 107976 210766 19060 21853 55982 104416 22059 51869 59004 56626 225896 14051 56196 22196 108138 100043429 93762 22385 11785 75570 15204 104884 319583 230674 52864 227525 19360 54125 27015 14050 69745 14049 17535 14048 21975 77782 19363 319186 19364 27354 319178 12021 319183 224008 319182 60530 81601 50883 327762 269400 59001 319190 19361 22594 114714 16882 209334 22427 19687 19090 19718 69263 15574 11920 319181 66979 12189 12190 235610 231724 237911 22596 19355 57434 14375 225182 74335 93765 26909 18538 235559 71711 12144 193796 381306 68275 106344 72151 18971 68240 18972 233826 19891 18973 18974 80905 19367 19356 19362 67967 268465 12649 78303 319188 15270 382522 REGULATION OF CDH11 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9759475 Regulation of CDH11 Expression and Function 12385 233833 59058 110751 12564 15426 24136 12388 16201 12387 236511 20613 20683 12552 57875 15227 213988 217351 214150 17454 56198 16480 76850 77630 239528 11492 239096 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME%R-HSA-4341670.3 Defective NEU1 causes sialidosis 18010 19025 12091 SIGNALING BY NOTCH3%REACTOME%R-HSA-9012852.3 Signaling by NOTCH3 328572 18011 13388 16449 240055 225164 11487 54485 16450 18514 218977 18131 67784 66894 18128 333639 19208 211652 21335 270118 667035 22190 12140 22608 12914 15213 14534 15214 13649 18519 15205 20846 19164 19165 15208 100042305 208117 19664 59287 100039623 56198 76580 13645 103806 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.5 Potential therapeutics for SARS 216848 11931 16451 58861 17973 11932 56480 11933 58194 58203 56188 56438 107932 22324 18566 16194 19646 234366 15519 11928 98660 232975 19712 245688 57780 16412 100042069 59095 23917 14815 108017 19877 20662 23942 16401 17192 170743 19878 16452 15516 229542 19766 22154 234779 70008 16453 16177 54721 11771 20963 50724 11772 57261 60406 18550 13609 71770 12229 20847 15980 17060 15979 18024 58799 12518 99982 217864 14228 15985 116871 15975 94246 18391 116870 100041953 110606 26554 71954 107392 14272 238247 232910 15353 50868 11773 100043508 14225 433759 12846 15182 81897 PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME%R-HSA-77595.4 Processing of Intronless Pre-mRNAs 68219 98985 228410 54451 68092 108062 67337 54196 83410 18789 433702 51786 94230 74320 68188 54188 66899 269061 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662361.2 Sensory processing of sound by outer hair cells of the cochlea 13823 17913 227357 192140 13409 238021 628870 332309 18419 97031 80979 20742 17524 56506 102502 224796 72088 98845 328789 56226 60613 16531 433899 16533 13860 17886 140492 329421 504186 227753 22350 19230 231252 241431 73750 12361 140476 16470 17910 19684 23999 22295 17921 17698 667663 381375 193385 20776 20740 11994 DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.4 Defective pro-SFTPC causes SMDP2 and RDS 20389 IMPAIRED BRCA2 TRANSLOCATION TO THE NUCLEUS%REACTOME%R-HSA-9709275.2 Impaired BRCA2 translocation to the nucleus 12190 20422 INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME%R-HSA-5638303.3 Inhibition of Signaling by Overexpressed EGFR 15200 11839 13649 21802 13645 12223 71920 13874 POSITIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764790 Positive Regulation of CDH1 Gene Transcription 16600 24136 93760 20683 20901 60611 15376 19645 16601 114142 21418 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME%R-HSA-1839122.3 Signaling by activated point mutants of FGFR1 80857 14180 14177 64654 14182 14175 14173 14164 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.5 Cation-coupled Chloride cotransporters 20495 20497 20496 107723 57138 20498 20499 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 96%3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) 18295 16545 14264 14595 116847 17022 27047 DEFECTIVE HPRT1 DISRUPTS GUANINE AND HYPOXANTHINE SALVAGE%REACTOME%R-HSA-9734281.2 Defective HPRT1 disrupts guanine and hypoxanthine salvage 15452 AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450408.5 AUF1 (hnRNP D0) binds and destabilizes mRNA 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 193740 667035 22190 59029 67089 15481 70247 208643 15507 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 18458 SCAVENGING BY CLASS A RECEPTORS%REACTOME%R-HSA-3000480.2 Scavenging by Class A Receptors 12843 12842 14325 20288 117158 140792 71693 11806 71145 17167 12827 12317 12826 238055 12825 11816 14319 22027 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.6 AKT phosphorylates targets in the cytosol 22084 12575 17246 12015 12371 12675 67605 11651 11652 606496 56637 12576 23797 54484 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME%R-HSA-9699150.3 Defective DNA double strand break response due to BARD1 loss of function 12021 12189 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME DATABASE ID RELEASE 96%159424 Conjugation of carboxylic acids 435528 107146 233799 233801 272428 117147 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013409 RHOJ GTPase cycle 216963 66894 12389 320634 68146 22319 20619 11855 277360 19349 26431 70584 68428 71302 229658 75739 217866 105782 94190 14269 22379 218581 80837 214459 21917 14467 66871 13830 224105 226751 16480 18708 76088 18709 218756 18479 56419 104445 223435 330914 232906 18481 71435 228359 404710 73178 20514 66508 54126 14609 22376 68524 71709 22042 SIGNALING BY MST1%REACTOME%R-HSA-8852405.2 Signaling by MST1 20733 20732 15451 15235 19882 CDH11 HOMOTYPIC AND HETEROTYPIC INTERACTIONS%REACTOME%R-HSA-9833576.1 CDH11 homotypic and heterotypic interactions 12385 12564 12388 12387 12552 16480 239096 SULFUR AMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%1614635 Sulfur amino acid metabolism 64918 246277 66902 14261 12583 12411 67870 211389 12116 67873 14719 14718 66071 73748 107869 56369 104923 27376 246221 211488 22117 56551 59010 226654 238505 11720 210009 269378 PELO:HBS1L AND ABCE1 DISSOCIATE A RIBOSOME ON A NON-STOP MRNA%REACTOME%R-HSA-9954714.2 PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 105083 24015 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME%R-HSA-8866654.5 E3 ubiquitin ligases ubiquitinate target proteins 22209 70620 140499 269523 12042 66105 667035 22190 109331 15007 22195 319186 319178 319183 319182 319190 19090 319181 100041766 93765 68366 18538 20585 76246 108089 214498 225131 67819 56273 66317 668173 103737 72129 19302 235497 66510 22083 268281 68441 109815 233900 320311 54624 78303 319188 216080 22210 22194 58186 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 96%168138 Toll Like Receptor 9 (TLR9) Cascade 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 100561 11909 26419 12675 216238 71398 27056 78287 16476 18033 18035 18036 11820 75669 81897 12234 225326 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 170743 14281 12370 22030 12475 67245 225471 106759 18034 54123 434174 66513 93765 66589 22034 66724 68652 20111 DENGUE VIRUS ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9918485 Dengue Virus Attachment and Entry 12737 16785 74153 22201 15530 12475 74244 171283 170786 103978 11771 11772 18550 71770 14733 15529 11603 23888 20971 232910 11773 20969 22200 14734 66663 231380 71951 17069 20970 68032 17289 14828 19128 276891 14735 217303 18708 22174 14456 26362 17533 100732 52898 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 96%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 67103 13479 16993 320997 17001 13120 11690 631304 11687 13118 72054 17250 208285 17164 14598 106648 319446 100040843 23887 11689 TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167243.5 Tat-mediated HIV elongation arrest and recovery 20922 20833 68705 98053 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 20020 231329 20021 69241 17749 100043714 58202 67923 27224 27632 20924 24116 12455 13716 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.2 Reactions specific to the hybrid N-glycan synthesis pathway 17309 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN PIGMENTATION%REACTOME%R-HSA-9824585.3 Regulation of MITF-M-dependent genes involved in pigmentation 20665 12387 67155 239985 20586 17918 20588 16842 20587 245049 70127 56456 16364 11652 29861 269397 20431 19708 268996 66993 11891 171531 26416 12055 12054 11461 77836 77045 83671 21418 18241 93760 22278 68094 83796 83797 57376 13190 22173 22178 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 96%983712 Ion channel transport 11931 14226 11932 20393 11933 11937 11938 65973 53313 56188 76757 109552 67972 11941 320707 381290 12322 12323 108058 12325 20192 20191 20190 107568 11928 98660 232975 57780 59095 108017 110157 13830 72621 242341 68775 76252 11972 108664 66290 640703 11964 110935 11966 100039636 66335 11973 11974 74915 338375 21871 73834 114143 66237 11975 54411 27060 140494 66144 225997 22063 193034 22065 22067 667035 22066 22190 28240 22068 63873 171382 69847 171166 75607 56407 279561 68667 208169 277328 11944 64177 11945 17364 382427 246788 27219 68279 69047 94178 11981 22368 11977 226025 101772 194352 117160 26946 170759 56843 170755 58800 11979 14628 54670 241118 11419 74772 50771 212989 319767 102566 404545 229277 338370 26372 224079 140475 50770 105722 382014 231287 14605 268878 11980 20278 78339 67331 235574 217843 320091 66388 252972 20276 20277 232341 56365 76295 233246 26373 12728 12727 83814 12725 12724 97086 12723 243634 23844 192113 74446 50769 24115 58170 99663 233979 320940 229933 54667 11982 12733 105355 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-3232118.9 SUMOylation of transcription factors 17342 27223 56469 20687 15248 17246 26927 21420 22059 21419 59004 20610 22196 100043429 229615 12578 116870 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.3 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 18148 110109 15510 17865 21418 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA2 RAD51 RAD51C BINDING FUNCTION%REACTOME%R-HSA-9704646.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2 RAD51 RAD51C binding function 12021 81601 327762 20422 233826 19361 114714 22427 19362 11920 12189 12190 237911 57434 19360 225182 26909 17535 21975 19363 19364 12144 27354 EUKARYOTIC TRANSLATION TERMINATION%REACTOME%R-HSA-72764.6 Eukaryotic Translation Termination 622534 238217 14852 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 235606 67186 382492 20055 75617 67768 27370 65019 629957 67674 20102 20103 668668 667739 14853 672214 66481 225058 100038875 100038991 68028 225363 100043000 67891 100043295 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME%R-HSA-167152.5 Formation of HIV elongation complex in the absence of HIV Tat 68092 433702 20922 20833 68705 98053 13871 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 14885 209357 66467 20020 231329 12454 20021 69241 66671 17749 100043714 58202 17420 67923 12572 27224 13872 27632 20924 24116 23894 12455 14884 72949 13716 LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5632681 Ligand-receptor interactions 16147 19206 14451 57810 15245 117606 20423 13363 LEADING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69109 Leading Strand Synthesis 18969 106344 18968 72151 18971 18972 19075 19076 19687 19718 69263 67967 69745 18538 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 96%1483166 Synthesis of PA 114874 28169 68262 66659 18806 55979 225010 18778 14732 215456 18805 14571 76768 18783 67512 14712 18779 239759 26971 333433 108958 99010 210992 14555 26970 26565 215708 102247 18784 18782 78390 66350 231510 52123 ASSEMBLY OF THE HIV VIRION%REACTOME%R-HSA-175474.3 Assembly Of The HIV Virion 73711 22088 67123 330192 268373 66914 18108 18550 667035 22190 107305 72543 194309 52348 ERBB2 REGULATES CELL MOTILITY%REACTOME%R-HSA-6785631.4 ERBB2 Regulates Cell Motility 13866 11848 13649 18183 83961 100042150 12223 13367 76890 13874 15200 211323 13645 TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.4 Toxicity of botulinum toxin type F (botF) 64176 22317 64051 22318 75209 AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.7 AMPK inhibits chREBP transcriptional activation activity 72674 108097 108099 20869 58805 108079 68465 11450 MITF-M-DEPENDENT GENE EXPRESSION%REACTOME%R-HSA-9856651.3 MITF-M-dependent gene expression 233833 20665 21415 18992 12387 12575 12550 67155 20586 20588 16842 20587 17295 12443 12566 11652 12047 21385 69675 19303 12558 13612 26416 16881 11886 21417 232313 21752 329581 18787 21418 21414 21416 17216 239985 17218 13367 19017 56456 66993 11972 93759 108664 66290 12578 11964 93760 11966 100039636 66335 11973 11974 114143 12043 13190 22173 22178 12531 20674 192119 245049 70127 16364 29861 269397 20431 19708 268996 16398 11891 171531 12055 12054 11461 77836 77045 83671 17364 18241 68094 83796 83797 57376 76850 239528 236511 17918 12189 213988 217351 214150 17454 22278 66355 15254 20466 18817 433759 68292 TRAF3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602571 TRAF3 deficiency - HSE 22031 106759 142980 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 18011 232232 13388 16449 240055 225164 20602 11487 54485 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 15213 56233 17869 15214 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 15205 19664 433759 15182 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.3 PIWI-interacting RNA (piRNA) biogenesis 66420 69833 67710 245841 69920 74068 20022 210510 74691 15519 57746 20020 98558 231329 83456 20021 330890 69241 72634 71981 17749 13206 100043714 17864 66715 94244 57749 83561 SOS-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 96%112412 SOS-mediated signalling 15461 16367 384783 18176 20662 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME DATABASE ID RELEASE 96%8876493 InlA-mediated entry of Listeria monocytogenes into host cells 104836 12388 12387 667035 12550 22190 20779 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME%R-HSA-174154.4 APC C:Cdc20 mediated degradation of Securin 52717 56436 99152 17463 668450 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 30939 107995 21762 22123 19179 19181 19182 217232 23996 56317 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9613829 Chaperone Mediated Autophagy 15129 21821 12638 19752 14580 11520 68146 26369 16784 57320 15185 667035 22190 66905 18541 15516 15481 15519 METALLOTHIONEINS BIND METALS%REACTOME DATABASE ID RELEASE 96%5661231 Metallothioneins bind metals 17752 17748 17750 17751 DISEASES OF BASE EXCISION REPAIR%REACTOME%R-HSA-9605308.6 Diseases of Base Excision Repair 234258 18294 72774 18207 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.5 Binding of TCF LEF:CTNNB1 to target gene promoters 21415 17869 12387 21414 12006 21416 12399 16842 HIV LIFE CYCLE%REACTOME%R-HSA-162587.5 HIV Life Cycle 12767 18108 16881 107305 72543 194309 52348 116733 73711 22088 67123 330192 76959 66201 19386 20479 66914 12504 19384 100088 12774 19385 18107 445007 270627 68092 228980 319944 21374 103573 433702 20922 20833 216185 108143 18550 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 69912 21343 209361 226182 12454 229906 103468 235459 24074 268373 83602 58202 68153 74197 67923 234865 27224 27632 24116 12455 72949 59015 13716 69736 63856 110379 14156 68705 98053 667035 13871 22190 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 66371 14884 108138 68953 75608 18571 319583 170762 108989 231042 227699 208092 223921 227720 66700 269113 66679 18141 23825 107939 69482 71805 54563 16646 19069 15361 70699 101739 72787 18226 218210 83814 105513 22596 14375 DEFECTIVE TRANSPORT BY SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5658471.5 Defective transport by SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) 63993 ASSEMBLY AND RELEASE OF RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRIONS%REACTOME DATABASE ID RELEASE 96%9820962 Assembly and release of respiratory syncytial virus (RSV) virions 15516 15519 ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 96%210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 105727 20511 14645 20512 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450604.4 KSRP (KHSRP) binds and destabilizes mRNA 72544 50911 69639 72662 19094 66446 227715 74108 70640 22631 11651 26416 66362 109075 66583 27998 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 96%418889 Ligand-independent caspase activation via DCC 12367 72993 13144 13176 69635 13143 107449 12371 94275 107448 LOSS OF FUNCTION OF KMT2D IN MLL4 COMPLEX FORMATION IN KABUKI SYNDROME%REACTOME%R-HSA-9944997.1 Loss of Function of KMT2D in MLL4 Complex Formation in Kabuki Syndrome 66310 140858 213464 23808 381022 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.3 Regulation of TP53 Degradation 17248 26931 12534 50883 20393 228829 12428 17246 56717 11651 11652 67338 11920 12566 53376 667035 22190 13163 227743 80751 12578 252870 12427 73699 109270 22059 12450 19052 78757 19053 51792 56716 23797 18607 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-163754.4 Insulin effects increased synthesis of Xylulose-5-Phosphate 21351 21881 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME DATABASE ID RELEASE 96%3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 15529 11603 23888 20971 14043 14042 20969 15530 14734 103978 71951 20970 14735 14733 MITOTIC PROMETAPHASE%REACTOME DATABASE ID RELEASE 96%68877 Mitotic Prometaphase 20873 68121 12534 78887 78798 22628 225745 231123 74360 18536 66296 214552 108911 73470 18541 16563 75786 15519 70454 18747 216965 13001 71876 13000 234663 100039026 19047 66977 320394 71909 19386 102920 237222 73699 11799 52276 59125 218914 59126 12235 217718 67037 17997 20842 68097 16319 18005 19052 73804 73738 19053 68475 51792 53598 20877 208518 381318 24061 52696 26886 66934 236266 18221 445007 19357 226849 225849 12009 72155 99100 26931 103733 21770 26932 22154 70385 74470 57294 104318 56455 101565 226747 17120 16328 219103 26951 100710 108000 229841 259279 12237 103573 14211 12617 83922 171567 107995 51885 72415 68298 83815 215387 12615 26370 76789 66570 72083 244495 70099 208628 101706 76707 233276 67139 103768 68014 74237 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 12442 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 22627 71521 13426 52504 13424 228421 20843 27373 227613 22153 22142 22145 100986 19088 230376 69654 75296 219072 225659 381306 76478 78177 28135 214444 76816 54130 18817 381644 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME DATABASE ID RELEASE 96%5668599 RHO GTPases Activate NADPH Oxidases 71893 23988 18762 19094 225326 18753 17969 237038 19353 224480 13058 241275 26416 13057 18751 18750 17970 19354 75669 26413 20201 17972 26417 20202 REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 96%3248023 Regulation by TREX1 22040 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME%R-HSA-77352.5 Beta oxidation of butanoyl-CoA to acetyl-CoA 15107 20216 11409 93747 CHROMATIN MODIFICATIONS DURING THE MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME%R-HSA-9821002.1 Chromatin modifications during the maternal to zygotic transition (MZT) 319178 319183 319182 232440 319190 319149 319176 319181 15077 75605 216850 75467 194388 18140 214899 74319 11628 22289 319169 625328 15267 78303 319188 319168 15270 319167 624153 319186 382522 DEFECTIVE FV CAUSES THROMBOPHILIA%REACTOME%R-HSA-9930483.1 Defective FV causes thrombophilia 14067 19128 19123 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.4 RNA Polymerase III Chain Elongation 70408 20018 69870 70428 17749 218832 100043714 67005 20016 12909 67065 74414 66420 69833 78929 245841 26939 67486 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME DATABASE ID RELEASE 96%933541 TRAF6 mediated IRF7 activation 328572 12914 56480 22030 15977 54131 56489 71586 230073 66641 21353 71956 228607 217069 54123 22034 LATE SARS-COV-2 INFECTION EVENTS%REACTOME DATABASE ID RELEASE 96%9772573 Late SARS-CoV-2 Infection Events 93687 71164 53618 20448 227619 19089 13200 208884 667035 12330 22190 101772 22196 102566 404545 105722 382014 66357 320091 50528 70008 233246 20014 18550 103963 243634 56637 69038 13135 15469 103534 67075 57377 27801 228136 75965 70546 20817 14423 108687 20815 214424 269181 328417 57437 606496 217664 67287 69035 80285 107895 52552 20446 671535 20444 547253 20442 80286 20443 17308 17158 68292 20440 67569 16430 14376 20447 DEFECTIVE DPM2 CAUSES CDG-1U%REACTOME DATABASE ID RELEASE 96%4719377 Defective DPM2 causes CDG-1u 13481 68563 13480 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 96%937041 IKK complex recruitment mediated by RIP1 56532 17087 12475 225471 11796 106759 12675 16150 16151 66105 667035 100041766 216080 21898 22190 93765 66589 22034 19766 11797 RESPIRATORY SYNCYTIAL VIRUS (RSV) ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9820960 Respiratory syncytial virus (RSV) attachment and entry 15529 11603 23888 20971 17087 20969 15530 12475 13649 14734 103978 16001 71951 13051 18550 20970 19345 271457 19344 21898 14735 14733 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME DATABASE ID RELEASE 96%110330 Recognition and association of DNA glycosylase with site containing an affected purine 319178 319183 319182 232440 319190 57321 319176 319181 234258 319152 18294 21749 497652 21750 319169 268395 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME%R-HSA-8847453.3 Synthesis of PIPs in the nucleus 219024 18718 108083 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME DATABASE ID RELEASE 96%1480926 O2 CO2 exchange in erythrocytes 19743 15129 15122 20533 230582 266690 320635 12346 72017 12349 12351 11826 POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.4 Potassium Channels 16514 60613 16531 16533 140492 20928 16519 16520 54393 16518 16516 16521 16522 16524 16513 16515 16517 242425 84036 140493 16534 240444 58802 16526 16527 223604 238076 15165 15168 225030 16535 72413 16538 16539 16497 74571 14697 16512 98741 66733 380728 240595 72258 16528 14710 16490 14699 16491 66066 226922 14700 16492 15166 16523 192775 20927 16485 170738 14708 16506 14706 16504 99738 16493 14704 16494 16498 14695 16495 242151 16500 16502 14693 268345 64337 16508 14709 56543 382571 241794 16510 211468 217826 14701 16511 56379 211480 332396 16499 67498 238271 330953 435726 52150 14702 16525 16530 14696 14688 16536 110862 SMOOTH MUSCLE CONTRACTION%REACTOME%R-HSA-445355.8 Smooth Muscle Contraction 12291 239556 11749 67938 17904 107589 242202 22004 434246 20410 26903 93689 17880 17898 54195 60596 59310 12391 16419 20411 109700 59069 19303 234889 16952 11669 67268 640703 12306 21894 224105 18479 17907 216459 58226 22330 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME%R-HSA-9634285.2 Constitutive Signaling by Overexpressed ERBB2 15461 13866 59079 12539 19248 18176 20662 15519 20416 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME%R-HSA-8877330.2 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 21936 12400 18019 12477 16184 20371 16183 15978 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME%R-HSA-77305.3 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 11370 97212 231086 DEFECTIVE MOGS CAUSES CDG-2B%REACTOME DATABASE ID RELEASE 96%4793954 Defective MOGS causes CDG-2b 57377 DEFECTIVE GALE CAUSES EDG%REACTOME%R-HSA-5609977.5 Defective GALE causes EDG 74246 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.4 MAP3K8 (TPL2)-dependent MAPK1 3 activation 12234 231130 26395 21402 12675 16150 26398 16151 18033 26965 667035 22190 26410 103583 NEF AND SIGNAL TRANSDUCTION%REACTOME%R-HSA-164944.6 Nef and signal transduction 19353 94176 15162 16818 224105 140580 14360 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3906995.5 Diseases associated with O-glycosylation of proteins 66548 13138 330267 207596 224697 56229 353328 239337 68273 77794 18129 94192 18131 279028 18128 18132 108902 21825 108153 23794 30806 108154 16795 210417 271127 229595 208936 77739 381694 269959 14425 269328 230145 100689 233744 235130 240322 20357 16848 11504 20356 17829 18636 100039649 21826 140474 224116 226866 217734 17063 59048 240913 223838 99011 237360 330119 216725 73732 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 96%397795 G-protein beta:gamma signalling 18796 18797 14702 18795 11848 14696 320207 11651 11652 14697 12229 14710 14699 66066 14700 14688 104709 14708 14706 14704 14695 73341 14693 64337 14709 14701 30955 18479 23797 18607 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.3 Signaling by FGFR2 amplification mutants 14183 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.6 Aflatoxin activation and detoxification 13479 13087 110198 13077 71522 207182 71670 13114 56615 211666 109652 66447 14598 319446 23887 G ALPHA (Q) SIGNALLING EVENTS%REACTOME%R-HSA-416476.8 G alpha (q) signalling events 18796 18797 18795 18710 18754 18755 320127 76192 26413 104418 26417 56077 66082 231871 380921 110524 269060 110197 217480 13139 13649 331374 18176 20662 15461 52666 18708 18709 18706 21390 19419 11550 11548 11549 11820 15560 15559 15558 14675 213788 14697 12671 14710 14699 66066 14700 12669 15465 18241 14708 14706 14672 14704 545156 14695 14676 14693 64337 14709 14682 14701 14702 223435 14696 14527 14526 23945 12229 16952 14688 70086 58861 14459 53978 22044 22045 624910 57260 233571 235036 246709 13617 19734 30044 16438 14715 16439 18798 14714 13615 18441 246691 18442 14745 16963 16995 208188 229214 16440 56183 56696 210198 58182 110651 19204 20112 104443 224065 19216 19220 64214 319239 14816 14289 12374 108071 238377 14744 225642 50778 19735 50780 19736 14829 67168 21333 11606 11607 12061 12062 17392 56470 216749 21338 19737 14064 65086 14063 14062 14061 21337 15200 23832 319197 21334 21336 240816 12424 12425 12426 217369 23939 227717 14065 381810 107221 280287 24111 574402 78134 100043254 237362 385643 433292 246313 233079 233080 233081 50501 67405 18216 14773 54615 12209 78826 114229 15171 110312 18217 387285 230777 14767 68039 18101 56533 18429 11998 18430 54140 26361 22065 22068 20210 26946 18753 110355 18761 19395 207911 20111 13616 13614 13618 18750 GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 96%202433 Generation of second messenger molecules 16428 17973 12500 18481 12501 234779 12502 12504 22376 17444 22323 18803 16818 224105 16822 22637 18479 16797 14969 14026 630146 14968 23880 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME DATABASE ID RELEASE 96%975155 MyD88 dependent cascade initiated on endosome 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 11909 26419 12675 16476 18033 18035 18036 11820 81897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 170743 14281 12370 22030 12475 67245 225471 106759 18034 54123 434174 66513 93765 66589 22034 66724 68652 20111 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME%R-HSA-9672391.3 Defective F8 cleavage by thrombin 14069 14061 22371 REGULATION OF CDH11 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9759811 Regulation of CDH11 mRNA translation by microRNAs 233833 213988 236511 217351 17454 214150 12552 76850 239528 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.4 Role of LAT2 NTAL LAB on calcium mobilization 14389 74769 56743 20963 18708 18709 17096 14360 18706 20662 18607 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME%R-HSA-9675132.4 Diseases of cellular response to stress 12571 12567 12578 SUCCINYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9853506 Succinyl-CoA Biosynthesis 100042811 18293 78920 13382 DISEASES OF BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-9865118.1 Diseases of branched-chain amino acid catabolism 78038 243382 227095 11992 72039 56357 110446 12040 12041 13171 13382 12039 93747 SIGNALING BY RAF1 MUTANTS%REACTOME%R-HSA-9656223.2 Signaling by RAF1 mutants 16706 20779 12322 109880 12323 108058 12325 26413 26417 12988 109905 640703 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 14161 21894 215449 11836 109689 216869 16452 110135 99571 22330 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME DATABASE ID RELEASE 96%2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 26965 18128 21402 56438 POLYMERASE SWITCHING%REACTOME DATABASE ID RELEASE 96%69091 Polymerase switching 18969 106344 18968 72151 18971 18972 19075 19076 19687 19718 69263 67967 69745 18538 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME%R-HSA-8936459.2 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 233833 232440 319149 15077 66310 140858 233904 213464 214162 67268 75410 14723 23808 16399 15267 21825 319168 319167 56744 76850 18022 319186 328572 319178 319183 319182 12400 236511 319190 231051 319176 18124 319181 14460 213988 217351 99890 214150 208043 18761 20467 17454 15469 319169 18519 20466 625328 78303 319188 15270 433759 22761 624153 381022 382522 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3315487.4 SMAD2 3 MH2 Domain Mutants in Cancer 17126 17127 17128 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.2 Regulation of TP53 Expression 12142 22059 REGULATION OF CDH11 FUNCTION%REACTOME DATABASE ID RELEASE 96%9762292 Regulation of CDH11 function 12385 110751 12564 12388 12387 12552 57875 16480 11492 239096 TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 68652 667035 22190 66513 26409 106759 22034 142980 66724 LAGGING STRAND SYNTHESIS%REACTOME DATABASE ID RELEASE 96%69186 Lagging Strand Synthesis 68275 18969 106344 18968 72151 18971 327762 68240 18972 14156 19075 19076 19891 19687 19718 69263 67967 16881 69745 18538 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.5 Signaling by CTNNB1 phospho-site mutants 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 REGULATION OF SIGNALING BY CBL%REACTOME%R-HSA-912631.3 Regulation of signaling by CBL 74769 18707 12402 17096 22612 22324 20963 107746 18710 12929 15162 12928 17060 18708 18709 14360 18706 GAMMA CARBOXYLATION, HYPUSINYLATION, HYDROXYLATION, AND ARYLSULFATASE ACTIVATION%REACTOME%R-HSA-163841.7 Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation 11881 65973 14068 71952 66632 13495 102115 58911 63828 107817 22021 276770 271970 56316 14058 69082 14071 67902 66901 22022 665189 69740 13494 194952 545260 269955 57295 238024 11883 77035 67014 67228 66521 105638 99349 74008 77041 270086 208691 330817 67728 116905 14061 18550 19123 667739 14069 19128 100038875 14456 13629 225363 NFG AND PRONGF BINDS TO P75NTR%REACTOME%R-HSA-205017.3 NFG and proNGF binds to p75NTR 18053 18049 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450520 HuR (ELAVL1) binds and stabilizes mRNA 15568 11737 69583 671392 18753 18750 227720 103573 HYPUSINYLATION%REACTOME%R-HSA-204626.3 Hypusinylation 276770 208691 102115 330817 MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 96%9694493 Maturation of protein E 667035 22190 REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.9 Regulation of Complement cascade 317677 71756 12759 12630 93721 12273 12274 545366 12259 17221 56373 12260 12902 12262 109828 12267 50701 14061 15139 14962 12263 12266 625018 230558 22370 319430 19128 333883 12258 110382 12478 12520 69379 12279 667277 50702 12628 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856828 Clathrin-mediated endocytosis 58194 20408 12402 215114 56324 15239 20404 20844 20405 13858 103967 104015 13649 12500 21802 12502 12638 12504 14269 12848 214459 109689 216869 100043806 26891 11607 238055 12223 71920 13874 20508 15200 21336 22320 26893 17113 74325 26894 15481 20955 18002 108679 13430 26572 72685 26895 16004 20980 19345 271457 22041 11839 19344 22318 20979 13645 22042 11998 53330 11555 12000 320634 22319 667035 22190 243764 16443 110355 100017 26754 13132 13043 73094 14366 229521 76709 194590 73178 210108 233489 22418 11771 218503 11772 30931 228998 71770 18704 56443 30934 74015 13854 66691 108800 80708 66616 20616 20403 68089 13855 67771 231580 11845 67602 56378 15463 18717 66713 29816 232910 74117 56017 11773 218038 30948 16835 13859 320129 12492 60510 269774 23969 20975 106628 13543 14725 16197 55925 66147 23970 67300 13429 170625 54609 12757 56085 SULFIDE OXIDATION TO SULFATE%REACTOME DATABASE ID RELEASE 96%1614517 Sulfide oxidation to sulfate 27376 22117 59010 211389 226654 66071 HDACS DEACETYLATE HISTONES%REACTOME%R-HSA-3214815.5 HDACs deacetylate histones 216848 20602 319149 107932 15077 170787 19646 234366 19712 245688 621893 23942 17192 319162 15267 319173 319163 319168 319167 229542 319186 319178 319183 319182 21372 319190 319176 319181 50724 81004 60406 56310 70315 99982 217864 15183 116871 20185 94246 116870 100041953 71954 107392 238247 15353 319169 78303 319188 433759 319189 15182 382522 MALATE-ASPARTATE SHUTTLE%REACTOME DATABASE ID RELEASE 96%9856872 Malate-aspartate shuttle 68267 71803 67863 14719 78830 14718 50799 17449 17448 SARS-COV-1 TARGETS PDZ PROTEINS IN CELL-CELL JUNCTION%REACTOME DATABASE ID RELEASE 96%9692912 SARS-CoV-1 targets PDZ proteins in cell-cell junction 56217 CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME DATABASE ID RELEASE 96%177135 Conjugation of benzoate with glycine 435528 107146 117147 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.3 FOXO-mediated transcription 14103 14377 16334 12575 109648 18044 56458 22628 18045 18046 110616 11651 12389 11652 433766 12576 76184 100039786 54401 55948 14815 17126 17127 17128 67731 20787 22166 243743 56338 12053 12359 16600 328572 59092 17684 54601 11604 19017 16006 15228 20869 93759 103988 12914 57264 17700 18519 22631 13198 13197 12452 20466 20656 56484 18976 433759 64384 19651 15182 12125 23797 68943 12226 18534 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.4 The role of GTSE1 in G2 M progression after G2 checkpoint 56299 56436 29870 17463 57296 12534 20422 26445 12575 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 13589 67089 70247 15519 22059 21762 12442 22123 19179 19181 19182 23996 19184 18817 26440 19166 19167 26441 26442 69077 15516 66997 23997 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.4 Translation of Replicase and Assembly of the Replication Transcription Complex 68953 105513 75608 56208 66383 67443 225326 78610 208092 75669 66371 66700 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME DATABASE ID RELEASE 96%5619047 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) 117591 NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%774815 Nucleosome assembly 319178 319183 72155 319182 232440 319190 217653 20892 233532 100038822 70645 319176 66311 66578 319181 12617 83815 12615 18148 66570 56505 19646 70454 67733 71876 76464 245688 320394 102920 319169 60411 66336 93762 78303 15267 319188 15270 319168 69928 319167 26886 52504 624153 319186 382522 VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.5 Virus Assembly and Release 12330 12317 ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 96%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 319178 319183 319182 232440 319190 319149 319176 76804 319181 17978 320795 15077 99982 11835 319169 625328 15267 78303 319188 319168 15270 319167 624153 319186 382522 FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839126.4 FGFR2 mutant receptor activation 14172 80857 14180 14178 14177 67112 68092 64654 14175 14174 14173 433702 14164 68705 98053 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 14183 80903 14165 PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9033241 Peroxisomal protein import 16922 71382 12908 17117 67528 66105 13142 74114 667035 110959 22190 70503 18126 11430 228061 224824 18634 15112 28200 56185 80911 71767 76263 13850 12012 15925 111175 19193 93732 20280 51798 74043 171210 11611 212503 17527 65098 56794 12359 22284 100041766 56273 668173 103737 72129 19302 14712 74147 171282 26458 15488 15926 113868 170789 26378 216080 15356 66887 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME%R-HSA-982772.3 Growth hormone receptor signaling 16367 15170 11491 12702 17096 20846 20851 20848 20850 14600 19116 216233 12700 19246 384783 12703 26413 16452 26417 19109 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 96%112307 Transmission across Electrical Synapses 14615 14610 55991 14617 406218 INFECTIOUS DISEASE%REACTOME DATABASE ID RELEASE 96%5663205 Infectious disease 56208 66383 67443 74153 78610 22201 74244 12389 18126 22325 100042069 23917 57257 171210 19877 15381 231380 11465 22352 19298 19878 70233 67224 378425 19655 218978 218035 15516 73075 66999 269061 70616 66892 68598 67959 12609 17395 672511 100040603 232989 269338 107701 67480 66286 72047 74326 67500 56298 17755 18452 16172 75956 18550 66861 56031 80744 69550 218490 22365 66101 19035 66270 70225 69019 18451 13684 80743 18655 68879 28185 320632 208643 67418 212880 66585 108098 74351 83486 74370 216705 66877 56529 23983 18521 83701 12695 57905 224912 68479 56217 77573 56216 13690 20980 15569 64176 209416 22317 66172 64051 20222 22318 320452 20614 67838 20979 60321 20907 50884 192191 75209 24088 83767 21897 14469 329165 78334 17713 257630 71893 66070 23845 66810 319322 12282 20683 105855 233726 66397 242687 19205 27967 20933 76936 171095 12412 69608 237038 15006 218811 71702 27061 99683 11308 68981 20639 229279 235623 240095 667803 241275 23881 13057 101943 108100 81898 67439 94315 20646 27041 101314 381379 14991 192159 71514 77371 23806 11993 55932 20334 67219 170779 21899 20390 53317 15382 70686 170761 53379 56258 66371 59013 98758 11991 68953 217365 16176 11834 75608 234852 12362 20168 15388 18571 15387 12363 12785 15162 228545 12526 66055 140580 17002 16396 236573 208092 68816 81910 66700 230861 19766 76199 67197 56532 213539 22230 54633 16173 109637 67465 17075 66624 56445 73158 69192 12721 19088 71732 69146 234779 53902 17918 14827 19108 67285 12499 236732 12267 223697 76709 67958 73178 68183 105513 104110 76479 16175 20963 20624 14678 66642 14677 233405 12229 64685 56443 68137 14687 75062 19200 77134 14679 27366 432530 228005 210044 76687 104111 13205 80987 28000 68089 13204 67771 246728 11867 76938 54483 16171 56378 233908 18438 66125 66713 74117 13542 70086 224129 245880 11512 11513 11514 11515 14191 13544 13543 22376 215280 14598 18439 319446 68524 67955 13035 11541 23959 23887 17882 14129 242851 19085 17913 13479 11931 58861 246256 11932 14131 11933 17909 66824 330319 216799 76884 12495 56188 19720 12322 12323 108058 12325 16881 229709 16438 16439 18747 11928 98660 232975 57780 16440 59095 108017 12527 22166 26400 26398 16193 15977 26419 18803 12048 13629 11491 107686 384091 666609 216766 621705 20595 66603 53975 192656 276919 20641 20638 69731 432803 67332 257632 12266 625018 107607 14917 108960 103534 57377 27801 228136 75965 70546 108687 269181 57437 217664 69035 107895 20446 20444 20442 20443 17308 17158 20440 67569 14376 20447 71164 53618 20448 227619 69940 19089 208884 107338 217344 20620 93671 16153 17886 70625 68975 234959 94112 70208 21849 13649 55948 23942 56771 50493 80509 22154 56310 26896 16834 216848 107932 18148 100039786 19712 229542 24127 67279 21349 99982 14228 13207 100043508 18854 59024 327987 192292 11350 17127 17128 17192 69790 22608 21762 22123 12675 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 14156 26446 19172 19173 19175 19697 13682 19177 13681 21402 16150 26443 26444 16151 19170 66413 16179 667035 22190 59029 26409 67089 75613 70247 14815 22196 621893 16401 319162 319173 319163 170743 56338 170744 264064 142980 317677 17195 12259 83814 72512 54123 22596 13211 14375 214763 216154 51813 15469 69792 67381 15182 12388 12387 20602 58194 12550 23989 20408 12402 56324 20779 15239 20404 17295 20844 20405 13858 104836 26416 12928 234366 26413 26417 28077 54401 171285 26395 26396 20662 19014 16452 328572 15129 17087 15368 15122 21372 11806 103573 81004 21898 18024 15183 20185 108664 12914 640703 268373 14225 16476 66899 22627 56480 54131 58203 56438 14697 14710 14699 66066 14700 14708 14706 14704 14695 14693 64337 14709 108138 14701 319583 14702 14696 18453 16453 16177 22418 11771 54721 11772 50724 60406 71770 13609 20847 15980 17060 15979 58799 12518 14369 217864 15985 15975 94246 14688 18391 100041953 110606 26554 71954 107392 14272 232910 238247 11773 15353 68219 98985 228410 54451 108062 110611 67337 83410 18789 18749 51786 94230 74320 68188 19645 13163 15529 216965 23888 20971 234663 19047 19386 20969 68097 71951 20970 14735 445007 57294 56455 15530 13806 103978 14733 69912 76246 214498 103468 66317 235661 235497 14734 234865 22083 59015 54624 69736 17069 110379 68032 17289 13427 14828 19128 276891 13426 217303 22174 13424 14456 26362 17533 100732 52898 12737 21872 68705 98053 13871 225913 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 11603 231329 20021 69241 66671 17749 100043714 101772 24018 17420 67897 12572 13872 20924 23894 14884 15267 102566 404545 319168 319167 224105 105722 382014 319186 319178 319183 319182 320091 319190 12475 22031 56489 56717 319176 18034 233246 319181 19353 20014 57261 103963 243634 56637 69038 227743 13135 19247 116871 51810 116870 14056 15170 319169 109270 67075 20846 14423 214424 328417 78303 606496 319188 67287 80285 52552 16818 671535 547253 80286 56716 68292 19092 23797 16430 382522 16451 13200 13626 319149 18108 22628 19084 22612 11651 11652 22324 15077 269523 18566 52615 107305 72543 19646 27681 70160 14360 194309 52348 116733 73711 13001 22088 13000 67123 100039026 330192 28084 245688 76959 66201 20479 66914 12502 17096 12504 18005 233870 78757 100088 12774 18708 19385 18107 18607 66357 12487 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 229906 235459 24074 83602 58202 68153 74197 67923 27224 71586 27632 230073 24116 66641 12455 71956 72949 228607 13716 217069 63856 20817 14609 20815 16001 13051 19345 271457 19344 93687 170786 11461 19349 16412 140579 94176 330662 170762 108989 231042 227699 223921 20430 227720 269113 66679 18141 23825 107939 69482 71805 11739 433923 11740 54563 16646 19069 15361 70699 101739 72787 19045 18226 218210 19046 27207 67097 670832 231413 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 14083 21803 20103 668668 667739 54188 67300 672214 12757 66481 225058 100038875 17925 100038991 68028 100043000 67891 100043295 18458 622534 238217 74568 16785 17973 666669 100040021 67025 12767 100043391 668182 241053 12317 18186 432502 100038882 19087 19989 76808 19899 100043184 19921 19934 100043755 11545 193740 12330 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 16211 100039592 16648 19106 100037258 100043876 100043893 100043423 100042986 20115 67281 54196 76846 13480 625646 100040298 68172 13481 100042740 19951 381686 16649 70572 19384 667618 100040970 267019 56040 67248 100040331 67941 68563 14104 50528 70008 171283 14061 13712 15200 64340 11840 622469 225027 15481 67996 51796 71713 233073 20382 110809 20383 21681 12846 108014 192170 69207 19826 75669 81897 100040029 225326 16194 69116 15568 22370 15007 12010 11768 11769 108012 11764 107975 11765 11767 252903 12759 56791 100041766 66513 93765 66589 22034 66724 68652 50868 22200 22631 75717 22629 66663 433759 22346 319189 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME DATABASE ID RELEASE 96%3656237 Defective EXT2 causes exostoses 2 15529 11603 23888 20971 14043 14042 20969 15530 14734 103978 71951 20970 14735 14733 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 13709 12400 16880 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.3 Biosynthesis of DPAn-3-derived maresins 11684 11689 TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.3 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis 11727 68626 192119 CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 96%156584 Cytosolic sulfonation of small molecules 20887 22021 76491 56362 319655 20859 242291 22022 20860 23827 73671 29859 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.4 Formation of RNA Pol II elongation complex 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 20924 23894 14884 68092 433702 20922 20833 67655 21399 107951 57314 114741 76246 214498 12454 66317 58202 235497 67923 22083 27224 27632 24116 12455 72949 54624 13716 64144 20926 93736 70122 74427 73473 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 96%1300642 Sperm Motility And Taxes 329954 212670 271036 16532 106757 225865 74096 320225 76856 RHOT2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013419 RHOT2 GTPase cycle 67095 67414 70827 214952 229877 170731 MET PROMOTES CELL MOTILITY%REACTOME DATABASE ID RELEASE 96%8875878 MET promotes cell motility 20779 17295 19353 107746 16398 12929 16400 12928 109905 16412 16775 16776 16777 16779 16780 14388 15234 226519 14083 16782 16772 23928 16773 16774 215449 319939 217169 67299 SUMOYLATION%REACTOME%R-HSA-2990846.7 SUMOylation 66341 26885 17342 109113 223701 100040573 67241 20602 66647 18854 67872 67040 320213 20230 56459 50995 55989 68501 19720 226026 17190 75826 223870 224903 21973 11545 21974 21969 13163 52615 12419 240087 56233 21849 19106 19386 21420 11799 21419 52276 15381 20842 12418 16319 57320 20877 24061 214669 445007 19357 12151 328572 19763 17246 54383 13619 17977 19017 241915 12416 17978 26370 19821 268903 15258 69912 12578 13006 12914 103468 22591 234865 30951 59015 69736 110379 13016 18035 20843 69260 216848 19697 16151 18148 22260 20181 22337 70238 19013 13436 27223 56469 13435 19365 13982 13433 22025 19883 11835 18227 14815 22059 59004 20610 208727 19016 22196 108138 100043429 110784 26423 19401 15204 229615 21834 15387 18667 170762 108989 231042 227699 223921 227720 269113 66679 22658 18141 107939 69482 71805 54563 56489 22427 19069 70699 18034 72787 18226 218210 12189 18538 12144 116870 68275 13207 106021 20687 15248 26927 212712 20878 20466 433759 22346 15182 67711 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME DATABASE ID RELEASE 96%5654708 Downstream signaling of activated FGFR3 327826 14172 80857 14180 64654 14175 18176 14388 20662 14173 14164 15461 107971 18803 80903 18708 19247 18706 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 96%9008059 Interleukin-37 signaling 320139 56294 19255 56480 15170 19258 17127 20848 12362 19248 19249 19250 19253 104831 19259 19247 19256 16182 24058 16068 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME DATABASE ID RELEASE 96%442729 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde 207565 100039592 640703 12323 12326 12325 55984 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.3 Toll Like Receptor 2 (TLR2) Cascade 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 20201 20202 11909 26419 12675 16476 18033 18035 18036 24088 11820 21897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 21899 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 22030 12475 67245 18034 12229 434174 66513 93765 66589 22034 66724 68652 20111 12703 MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME%R-HSA-429958.5 mRNA decay by 3' to 5' exoribonuclease 72544 50911 66317 69639 72662 66446 227715 218343 56422 68106 69305 66362 109075 108077 66583 27998 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 96%3214841 PKMTs methylate histone lysines 13626 319149 231051 110147 19697 18034 15077 66310 140858 70673 226830 233904 52615 208043 107823 19646 213464 214162 14056 245688 75410 69726 208266 232811 23808 239122 54343 11569 213389 67956 66083 52690 77683 18033 18193 14013 20937 192195 73251 225888 64707 84505 234135 235626 381022 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME%R-HSA-1614558.10 Degradation of cysteine and homocysteine 246277 14261 12583 211389 14719 66071 73748 107869 27376 246221 211488 22117 56551 59010 226654 METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 96%1237112 Methionine salvage pathway 56369 104923 66902 67870 67873 14718 CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME%R-HSA-9711123.6 Cellular response to chemical stress 67443 20602 12575 216799 13666 11651 11652 269523 27401 13001 13000 100039026 17869 50493 22166 19014 229003 20657 14630 76408 328572 66401 15129 14780 14778 15368 14775 15122 26462 12013 67305 21372 12460 109151 11833 11911 17977 11927 20293 69590 76650 17436 17135 75221 17978 50527 59035 14950 81004 17134 66993 18412 27407 75512 68350 14776 56551 18104 11758 18024 14859 11757 15369 140742 15183 224111 20185 109778 233016 71389 12578 106766 12914 667310 14629 56406 12858 26357 12857 21762 22123 19179 19181 19182 20656 23996 110323 21351 19184 18033 230784 26440 18477 19166 11839 12861 21672 12043 20463 19167 18590 13645 26441 12048 12862 26442 69077 12868 66997 23997 66142 14381 12234 56436 20459 17463 12866 57296 12865 20422 26445 100041785 26446 20683 19172 19173 21881 19175 17250 72345 19697 17969 19177 18128 21402 56438 26443 26444 19170 18759 66413 13058 26965 667035 13057 22190 333182 59029 17970 67089 17972 70247 110208 17708 20181 17709 17710 19013 11977 18753 20821 217365 56338 380975 12359 84682 22230 670717 50758 17992 18453 12189 50490 56637 11657 26554 14080 50868 233826 26570 108079 20466 20848 15926 23797 MATURATION OF SPIKE PROTEIN%REACTOME DATABASE ID RELEASE 96%9683686 Maturation of spike protein 19089 12330 17308 57377 14376 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.4 PI-3K cascade:FGFR2 327826 14172 80857 14180 14178 14177 67112 64654 14175 14174 14388 14173 14164 80903 18708 19247 14165 18706 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME DATABASE ID RELEASE 96%187706 Signalling to p38 via RIT and RIN 18211 109880 18049 19762 19769 MYOGENESIS%REACTOME%R-HSA-525793.4 Myogenesis 12385 12387 26399 21423 17260 12558 17261 26416 17258 29857 21406 11350 70834 12555 12386 19094 21413 17877 17878 12175 18209 57810 12561 17927 17928 18007 CREB PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 96%199920 CREB phosphorylation 17164 20111 73086 110651 20112 100040260 DEVELOPMENTAL CELL LINEAGES%REACTOME%R-HSA-9734767.4 Developmental Cell Lineages 21802 14178 16775 16776 16777 14175 16779 16780 14173 226519 14268 16782 16772 23928 16773 16774 11839 22370 13645 14165 19109 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.3 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 217666 76187 98314 TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME%R-HSA-8878171.5 Transcriptional regulation by RUNX1 233833 232440 20375 18854 319149 67155 20586 20779 20588 12571 20587 12443 12444 12445 15077 66310 21936 241196 67296 140858 233904 12005 213464 83766 214162 11350 13001 67268 13000 100039026 75410 22601 14723 23808 12418 76073 12741 21825 56744 12477 12151 69257 328572 13709 12143 19763 13038 18507 12400 13039 54383 231051 13619 239985 12702 241915 14462 56456 12416 16854 18124 14461 14460 22062 66993 99890 19821 72780 208043 15258 12914 494448 16880 93760 66923 18019 21762 30951 22123 19179 19181 19182 23996 19184 26440 19166 19167 17863 12981 26441 26442 69077 66997 381022 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 21872 14732 21423 19170 66413 667035 22190 18751 59029 67089 16184 21406 70247 16183 66671 13982 17420 12572 319974 16399 68094 83796 15267 83797 57376 319168 319167 16396 76850 18022 239528 319186 15978 319178 319183 319182 236511 319190 67057 319176 20371 319181 56353 213988 217351 214150 21349 19247 18761 20467 17454 15469 319169 18519 109594 20466 16909 625328 78303 16825 319188 15270 433759 22761 624153 71393 77044 382522 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%421270 Cell-cell junction organization 233833 16451 20665 12388 232440 19089 12387 13200 13626 12550 319149 20586 20779 13858 15077 104836 13345 12558 21417 52615 19646 26413 26417 21418 22325 13001 13000 100039026 17869 245688 18109 209462 22160 16480 16452 22330 66357 224619 66286 228839 18550 18553 69019 93759 226970 56529 12695 224912 56217 13017 13016 16456 20683 93742 56513 330662 56198 140580 77630 11492 239096 11797 12385 59058 110751 12564 15426 66624 16201 330914 20613 12552 57875 15227 11798 54721 99982 76687 228913 11727 217734 99011 11735 19645 12330 20901 60611 16601 114142 12741 16600 53325 17246 16193 12555 93760 13430 12561 21762 22123 19179 21844 19181 19182 64945 67956 23996 71740 19184 105837 18033 58235 26440 19294 19166 94332 71908 19167 15220 60363 26441 54420 58187 26442 54419 69077 12738 66997 93737 23997 54725 56863 12737 56436 75677 17463 215654 57296 320873 20422 12565 24136 26445 241201 26446 12563 19172 53624 19173 12562 19175 12739 15376 19697 12740 19177 12560 12557 12554 26443 56492 26444 16195 22431 19170 621628 21423 18759 14694 75339 66413 330222 192173 667035 56173 22190 239857 242653 239931 59029 230738 18746 16194 67089 76007 56805 70247 58220 21406 237979 21885 58998 18554 227485 18417 227377 114141 75234 15267 319168 319167 13040 13030 76850 239528 319186 319178 319183 319182 236511 319190 319176 319181 19353 20014 213988 103963 217351 214150 69038 13135 20583 14056 18717 17454 319169 57377 20848 625328 78303 319188 15270 433759 624153 15182 16430 14376 382522 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.4 TRAF6-mediated induction of TAK1 complex within TLR4 complex 68652 17087 12475 225471 106759 108960 667035 21898 22190 66513 26409 22034 66724 INTERFERON SIGNALING%REACTOME%R-HSA-913531.6 Interferon Signaling 16451 56208 12534 74153 13666 20892 19043 17999 26413 26417 55948 110157 11465 17750 16362 16452 66892 12702 18550 69550 13684 208643 71586 230073 228607 217069 13690 14469 54131 15006 240095 18148 667803 11461 14991 23806 55932 66369 22059 12362 19246 20698 170762 108989 236573 231042 227699 192176 223921 230861 227720 269113 66679 18141 107939 23988 69482 71805 16201 16363 54563 16646 19069 70699 72787 18226 218210 18712 54721 14229 20847 15980 15979 15975 246728 110606 14272 14129 17973 18854 100038882 12322 12323 193740 108058 12325 17967 19255 16211 100039592 16648 19106 100037258 19386 73699 19204 19052 19053 381686 51792 16649 17131 12505 445007 226849 26399 24015 69912 15481 22608 103468 15977 234865 12675 59015 69736 27056 110379 18803 69928 14828 192170 13682 13681 16150 23992 16364 21357 16151 667035 22190 24110 56469 12265 80876 74735 18753 22329 20821 19824 23960 225467 67781 22196 65972 229900 246727 56045 17318 56417 231655 93679 66141 15007 224762 12010 13665 286940 67204 67525 58185 70110 26905 211948 15512 15482 15978 54139 57444 52668 56791 67513 67030 55992 667370 101700 112419 15958 76500 101831 24014 13653 15061 104806 94088 80890 16913 360213 54123 20617 56631 16391 226641 13211 71885 22670 319236 93765 14087 19247 15894 214158 14969 229644 14968 100040608 237211 15900 72775 229898 66854 14088 15170 60534 20846 20848 12703 22194 MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 96%2555396 Mitotic Metaphase and Anaphase 52717 99152 668450 12534 238799 116733 30939 100088 98386 103573 22147 16906 22151 22143 53857 22152 227613 22153 22142 22146 67951 73710 13726 22145 66371 71782 545486 238463 68953 75608 170762 227699 208092 66700 380664 269113 23825 107939 69482 71805 70699 67141 72787 18226 105513 71978 108911 73470 16563 75786 70454 216965 71876 16211 234663 19047 66977 320394 19386 102920 73699 11799 52276 218914 12235 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 19384 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 100710 108000 229841 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 21762 12442 22123 60411 66336 59015 19179 69736 19181 67052 19182 232987 23996 12236 19184 236930 110379 26440 69928 19166 13427 76499 19167 71521 13426 26441 52504 13424 26442 228421 69077 20843 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 22196 22367 71955 64383 224640 319965 105988 50850 100042651 217232 56317 59008 18817 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 TBC RABGAPS%REACTOME DATABASE ID RELEASE 96%8854214 TBC RABGAPs 93739 22241 54189 227800 66687 67443 207592 19326 70296 67231 106039 71648 17274 19349 64930 11845 22084 53869 68449 381605 67046 100855 19341 56486 108995 270192 19345 77407 271457 19337 19344 269589 74105 224617 19346 260302 235442 233204 56715 103724 19338 209815 ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 96%1482788 Acyl chain remodelling of PC 18778 14792 329502 66857 271844 67452 237625 665270 270084 53357 67216 68255 232889 225845 18783 18779 26971 99010 210992 26970 26565 18784 18782 78390 66350 LOSS OF MECP2 BINDING ABILITY TO 5HMC-DNA%REACTOME%R-HSA-9022534.2 Loss of MECP2 binding ability to 5hmC-DNA MANIPULATION OF HOST ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 96%9636667 Manipulation of host energy metabolism 18655 13806 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 96%9627069 Regulation of the apoptosome activity 56369 670717 11783 74268 72565 66593 12371 26413 11798 26417 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.4 FasL CD95L signaling 14103 14082 12370 14102 RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME%R-HSA-76046.4 RNA Polymerase III Transcription Initiation 21374 67065 71752 74414 233863 66420 72308 69833 66596 227644 78929 245841 66653 544971 77634 70239 20841 18986 269252 102209 26939 330959 67486 75627 70408 20018 69870 70428 67371 17749 218832 100043714 67005 20016 98488 12909 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 96%2428924 IGF1R signaling cascade 14389 74769 16367 14172 80857 18576 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 327826 16370 16002 16000 18176 14388 20662 15461 16001 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 18607 ZYGOTIC GENOME ACTIVATION (ZGA)%REACTOME DATABASE ID RELEASE 96%9819196 Zygotic genome activation (ZGA) 328572 12914 21679 100043167 230594 547035 214290 22601 22059 HISTAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390650 Histamine receptors 225192 15466 15465 99296 T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME DATABASE ID RELEASE 96%2033515 t(4;14) translocations of FGFR3 14184 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.4 Hh mutants are degraded by ERAD 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 216440 26444 19170 269523 66413 667035 22190 59029 67089 70247 66753 116891 20338 74126 21762 22123 20423 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 96%429947 Deadenylation of mRNA 78893 69125 18983 74108 13682 13681 52846 231464 58184 75705 13684 208643 230594 234594 214290 218693 103135 72587 53621 72068 232791 104625 228140 192170 18458 SCAVENGING BY CLASS B RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000471 Scavenging by Class B Receptors 12491 18477 434174 11806 20210 238055 11801 269855 20202 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-HSA-453279.6 Mitotic G1 phase and G1 S transition 17187 12534 12575 211586 13555 19645 21781 12571 12567 12443 11651 12566 11652 12444 12445 13557 12447 242705 21973 27401 12448 12577 20135 12576 19646 12545 11350 17869 73699 17096 13548 22171 21877 13361 19052 19053 51792 16452 12428 17216 17215 17217 17218 17219 17220 12544 100043858 12580 12579 12578 50496 13559 104394 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 19650 26441 19651 63955 22390 26442 17865 72568 69077 66997 12530 231506 23997 629959 54124 56436 27214 20459 17463 67177 75660 57296 23834 20422 26445 26446 57441 19172 70024 19173 19175 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18969 18968 66671 19075 19076 17420 12572 59001 67141 66979 50793 18392 18393 66634 26428 26429 56452 18538 68275 68240 19891 18973 18974 71978 433759 23797 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.2 LXRs regulate gene expression linked to cholesterol transport and efflux 328572 233833 20602 236511 21372 17977 11307 22259 11816 11303 213988 81004 217351 214150 56310 99982 15183 20185 22260 20181 20182 17454 11812 11813 11425 67470 27409 67484 218214 11815 320982 230674 104263 76850 239528 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%500792 GPCR ligand binding 17202 17201 22094 12640 140498 212108 19773 242093 381489 239336 16336 23919 21390 11550 11548 11549 11820 11554 11555 11556 15560 15559 15558 213788 15557 13492 57265 382348 13733 13491 381853 13490 14607 13489 22226 13488 14697 111174 93897 215855 19206 503558 54598 215854 22412 12672 216795 12671 19226 15552 14710 15466 14699 15551 66066 15550 14700 243764 22410 12669 93896 15465 22414 99296 22411 18241 14708 209512 14706 15566 22409 15565 12310 15563 14704 15562 11516 225192 14695 14652 11517 12311 14693 20423 64337 14709 15874 12921 12919 22417 12918 14701 114640 223780 54409 19227 19228 56089 213527 51801 13363 14602 14601 319757 11535 14702 93735 83428 14696 14527 14526 14367 14365 26364 14362 22415 14366 22413 12267 22416 22420 22418 14370 22354 22422 13609 14371 22421 22353 20287 14368 22423 14369 22355 20890 19207 14688 22408 16147 70086 11541 58861 20293 54393 242425 18429 11998 18430 54140 26361 12000 212541 20210 15139 12266 207911 14419 12772 12774 12768 80901 14747 84112 20607 387512 59289 12776 12775 12458 12773 12771 170458 18386 18389 14539 23925 19214 243270 239283 387513 19222 14427 19217 18166 19218 19219 18167 18168 14294 12802 14293 12801 14309 387353 387515 353148 12765 227288 14308 56838 57811 17773 244701 353165 387348 387356 19156 20605 19065 20606 19064 211578 80885 272031 12145 20609 20608 14428 13051 227289 75769 217212 208990 216152 22439 110326 83770 20132 140795 57349 17171 30878 623503 107522 17329 20290 17200 18155 55985 20303 109648 20304 12057 20306 20296 20292 20302 57385 20295 20297 100039973 74191 100038965 20299 13610 56066 20311 20312 20300 11539 11540 18610 18619 229791 235044 11542 252837 66102 13611 22095 330122 14823 108073 268934 94226 108069 108068 20310 14825 353344 14429 14764 13603 11609 23796 83771 574417 387347 57253 12777 57254 387355 387342 387349 226278 12766 226304 387616 321019 12778 381073 110168 75805 436440 76854 12769 64095 15199 230857 14763 54199 70839 171469 16866 16867 227326 14739 12854 13349 16952 15945 20315 12767 53978 22044 22045 57260 233571 235036 13617 30044 14715 14714 13615 18441 246691 18442 14745 16963 16995 208188 229214 56183 56696 210198 58182 19204 104443 224065 19216 19220 319239 14816 14289 12374 108071 238377 14744 225642 56744 14829 67168 21333 11606 11607 12061 12062 216749 21338 14064 65086 14063 14062 14061 21337 23832 319197 21334 21336 12424 12425 12426 217369 227717 14065 381810 107221 280287 24111 574402 78134 100043254 237362 385643 433292 246313 233079 233080 233081 50501 67405 18216 54615 12209 78826 114229 15171 110312 18217 387285 230777 11551 14767 11552 68039 11553 18101 18387 18390 319430 12273 20604 13616 13614 18976 17199 13618 17203 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%205043 NRIF signals cell death from the nucleus 67733 26419 19164 19165 100042305 18053 208117 18412 59287 100039623 667035 22190 18049 22034 REGULATION OF EXPRESSION AND FUNCTION OF TYPE I CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764274 Regulation of Expression and Function of Type I Classical Cadherins 233833 12388 232440 19089 12387 13200 13626 11735 12550 319149 20586 19645 20779 13858 15077 104836 13345 12330 20901 21417 60611 52615 16601 114142 19646 26413 26417 21418 13001 13000 100039026 17869 245688 18109 22160 16480 22330 16600 66357 53325 17246 66286 228839 18550 18553 69019 93759 93760 13430 21762 56529 22123 19179 19181 19182 67956 23996 19184 105837 26440 13017 19166 13016 19167 15220 26441 26442 69077 66997 23997 56436 17463 57296 20422 24136 26445 26446 20683 19172 19173 19175 15376 19177 26443 26444 22431 21423 19170 14694 75339 66413 192173 667035 22190 59029 18746 67089 76007 56805 21406 70247 21885 18554 15267 319168 319167 13040 13030 76850 239528 319186 12385 319178 319183 319182 66624 236511 20613 319190 330914 319176 319181 20014 213988 103963 217351 214150 69038 13135 99982 76687 228913 20583 14056 18717 17454 319169 57377 625328 78303 319188 15270 433759 217734 99011 15182 624153 16430 14376 382522 PD-L1(CD274) GLYCOSYLATION AND TRANSLOCATION TO PLASMA MEMBRANE%REACTOME%R-HSA-9931295.1 PD-L1(CD274) glycosylation and translocation to plasma membrane 66357 16451 13200 72297 67075 20014 103963 60533 58205 76580 18566 69038 80286 13135 68292 16430 G-PROTEIN ACTIVATION%REACTOME%R-HSA-202040.3 G-protein activation 14708 14672 14706 14702 14704 14696 14695 14676 14675 14693 64337 14709 14697 14682 18976 14701 18390 14710 14699 18610 66066 14700 14688 HYALURONAN DEGRADATION%REACTOME%R-HSA-2160916.7 Hyaluronan degradation 114332 15366 56398 15587 192188 20544 235504 110006 77042 15586 80982 109685 12505 15212 15211 74468 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702632 sunitinib-resistant FLT3 mutants 14255 HS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022928 HS-GAG biosynthesis 14043 14042 15531 15530 103978 54710 628779 54616 58193 50785 14733 70484 83398 50786 23908 15529 11603 23888 20971 93683 20969 14734 64580 15476 15478 195646 71951 17423 20970 328779 14735 50787 319415 DEFECTIVE DHDDS CAUSES RP59%REACTOME%R-HSA-4755609.4 Defective DHDDS causes RP59 67422 52014 KILLING MECHANISMS%REACTOME%R-HSA-9664420.3 Killing mechanisms 19353 13543 71893 22418 16476 241275 13542 13057 26419 14369 237038 13544 SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 96%5654688 SHC-mediated cascade:FGFR1 80857 14180 14177 67112 64654 14175 18176 14174 20662 14173 14164 15461 14165 ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.3 Antigen processing-Cross presentation 56436 17463 57296 20422 26445 26446 19172 19173 19175 17969 12317 19177 16150 15006 26443 26444 16151 19170 22319 20619 240095 17874 66413 667803 13058 667035 13057 22190 59029 17970 67089 14991 17972 70247 117149 12491 21899 20193 14161 15007 13040 12010 110135 99571 17087 16912 13039 19171 12475 14827 16419 16913 19186 12229 19188 434174 57743 21898 17534 22320 21354 21356 21355 53421 20909 20201 240028 100043039 20202 246278 66212 20333 21762 22123 12675 16410 19179 19181 19182 23996 19184 26440 19166 19167 26441 24088 26442 21897 69077 17533 14129 66997 23997 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME%R-HSA-5619035.3 Defective SLC17A5 causes Salla disease (SD) and ISSD 235504 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.3 Sensory processing of sound 13823 17913 227357 192140 13409 238021 628870 332309 18419 97031 80979 20742 17524 56506 102502 224796 72088 67972 98845 328789 56226 60613 16531 433899 16533 13860 17886 140492 329421 504186 227753 22350 19230 19339 13002 20964 56808 12296 240899 83762 26875 12343 12345 12217 12289 216227 29866 20977 12340 231252 241431 73750 12361 140476 16470 17910 22318 19684 23999 20614 22295 17921 20907 17698 667663 381375 193385 20776 20740 11994 SIGNALING BY TGFBR3%REACTOME%R-HSA-9839373.1 Signaling by TGFBR3 328572 233833 236511 20683 14173 21423 213988 217351 21812 21813 214150 21406 20181 21413 17877 17454 17878 21858 17927 21857 17928 15201 17127 16323 17128 19164 16322 18109 19165 21814 21803 21808 100042305 118445 208117 67903 19401 59287 17387 100039623 11480 17389 109689 216869 76850 239528 PHENYLALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964208 Phenylalanine metabolism 18478 70266 14204 110391 13180 66514 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 96%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) 20525 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.6 TGF-beta receptor signaling activates SMADs 16998 68010 17872 320910 65112 14479 108075 16420 56424 170749 56207 12402 241226 19045 103573 83814 16419 18550 21812 19046 667035 21813 22190 20901 18002 19047 16412 17126 14225 17127 17128 16410 22192 16416 21814 21803 21808 75788 66313 17131 21809 268977 16997 DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.2 Downregulation of ERBB2:ERBB3 signaling 13866 211323 667035 22190 84092 100042150 23797 11651 67588 11652 CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963888 Chylomicron assembly 17777 66397 11806 11813 11814 238055 11807 11808 18453 11816 DEFECTIVE GALM CAUSES GALAC4%REACTOME%R-HSA-9931929.1 Defective GALM causes GALAC4 319625 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427413.4 NoRC negatively regulates rRNA expression 232440 319149 667501 57230 21429 20019 269003 15077 21340 17191 21339 21341 64424 22130 13871 75316 66420 70333 69833 116848 66136 245841 20017 14885 209357 66467 13436 66671 13433 17749 100043714 17420 12572 13872 23894 14884 93762 15267 319168 319167 319186 319178 319183 319182 319190 319176 21374 319181 50724 60406 94246 20467 100041953 20018 71954 20016 319169 20466 625328 78303 319188 15270 433759 15182 624153 382522 ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 96%2214320 Anchoring fibril formation 16782 16774 24087 21892 12836 12153 16780 LORLATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717329 lorlatinib-resistant ALK mutants 11682 DEFECTIVE VWF CLEAVAGE BY ADAMTS13 VARIANT%REACTOME DATABASE ID RELEASE 96%9845621 Defective VWF cleavage by ADAMTS13 variant 279028 22371 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9683673.5 Maturation of protein 3a 14423 20448 20446 20444 20442 20443 20440 20447 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.4 Transcriptional activation of p53 responsive genes 29813 59092 12575 22059 CELLULAR RESPONSE TO HEAT STRESS%REACTOME%R-HSA-3371556.3 Cellular response to heat stress 269523 12322 12323 193740 108058 12325 26413 26417 12955 15499 15519 72630 56354 50497 12017 81489 70356 67669 219158 19386 29810 18415 110920 67384 66538 70369 23950 15525 15505 17164 68196 22791 80888 73442 170762 108989 231042 227699 223921 227720 15516 445007 269113 15512 66679 15482 18141 328572 213539 107939 69482 71805 54563 19069 56717 70699 72787 11920 18226 218210 15185 56637 14228 69912 93759 15481 68275 12914 103468 68240 19891 74370 234865 100043508 67605 59015 69736 15526 110379 14828 22627 56716 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.2 Formation of Incision Complex in GG-NER 56438 70620 26370 77593 11545 13871 68058 667035 22190 93765 93836 14885 209357 66467 11546 13870 68275 56469 66671 19358 68240 19359 22590 19891 17420 22591 107986 12572 22592 13872 50505 20610 23894 14884 22196 100043429 229615 99375 72584 13194 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.3 TRIF-mediated programmed cell death 56532 17087 21898 12475 14082 225471 106759 12370 19766 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163358.7 PKA-mediated phosphorylation of key metabolic factors 18747 18639 58805 18749 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5660724.5 Defective transport of neurotransmitters by SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) 13162 ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 96%1169408 ISG15 antiviral mechanism 16451 56208 74153 54131 13682 13681 19043 100038882 667035 22190 17999 24110 26417 23806 16211 100039592 16648 19106 19386 381686 16649 170762 108989 286940 231042 227699 223921 227720 445007 230861 269113 66679 18141 66892 107939 69482 56791 23988 71805 54563 112419 16646 19069 70699 72787 18226 218210 93765 69912 13684 103468 208643 234865 230073 20846 59015 217069 69736 13690 110379 18803 192170 22194 P38MAPK EVENTS%REACTOME DATABASE ID RELEASE 96%171007 p38MAPK events 15461 17164 19094 26416 102626 19730 56044 64143 26415 18176 29857 TOXICITY OF TETANUS TOXIN (TETX)%REACTOME%R-HSA-5250982.4 Toxicity of tetanus toxin (tetX) 22318 DEFECTS OF CONTACT ACTIVATION SYSTEM AND KALLIKREIN-KININ SYSTEM%REACTOME%R-HSA-9946127.1 Defects of contact activation system and kallikrein-kinin system 58992 16621 12258 14061 GLUTATHIONE CONJUGATION%REACTOME DATABASE ID RELEASE 96%156590 Glutathione conjugation 14866 68312 100042314 14874 14871 68044 68214 71522 207182 56615 211666 66447 14859 14629 76263 14863 14598 14873 14854 69065 75475 13885 14872 54486 23887 68252 66054 58810 14862 14630 14865 ASL VARIANTS CAUSE ARGININOSUCCINATE ACIDURIA%REACTOME DATABASE ID RELEASE 96%9956529 ASL variants cause argininosuccinate aciduria 109900 RNA POLYMERASE I TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73864 RNA Polymerase I Transcription 216848 232440 319149 667501 107932 21429 20019 15077 21340 17191 21339 21341 64424 22130 13871 75316 66420 70333 69833 66136 245841 20017 19646 234366 26417 14885 209357 66467 66671 17749 245688 100043714 17420 12572 13872 23894 14884 23942 17192 15267 319168 319167 229542 319186 319178 319183 19285 319182 319190 319955 106298 110147 319176 21374 319181 116871 116870 20018 14534 20016 319169 18519 12417 625328 78303 319188 15270 433759 15182 624153 382522 CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.6 Cytosolic iron-sulfur cluster assembly 109006 18971 237911 269400 13871 78797 26426 68523 72199 26425 26371 67563 SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.2 Signaling by plasma membrane FGFR1 fusions 244373 67384 14182 FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.4 FGFR3 mutant receptor activation 14172 80857 14180 14184 80903 64654 14175 14173 14164 GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.5 GABA B receptor activation 242425 14702 14696 14680 16519 16520 104110 54393 14697 14678 16518 14677 16516 14679 14710 432530 14699 210044 66066 104111 14700 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 224129 11512 14693 11513 11514 16517 64337 11515 14709 14701 242851 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%8868773 rRNA processing in the nucleus and cytosol 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 55989 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 66362 67248 109075 100040331 66583 67941 27998 72544 50911 69639 72662 66446 227715 57294 104318 56200 72515 67676 27993 102614 50912 67619 66878 217109 110816 68327 66138 229504 208144 98956 67276 67973 18114 18572 78394 53414 216156 269470 59028 12181 21771 110109 75273 215193 64934 217995 67674 73674 67755 68272 213895 76130 216987 66254 66249 353258 56095 71340 224823 102462 69072 213773 105372 67205 27373 72554 104662 67053 52705 230082 245474 223499 269536 80886 70683 100041622 97961 233802 24128 66164 66181 27966 57750 74035 100608 100040177 234374 68147 667035 30877 75416 57315 52530 14113 68979 208366 227522 14791 57316 67045 54364 72198 65961 622491 68533 67134 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME DATABASE ID RELEASE 96%114604 GPVI-mediated activation cascade 74769 18762 11848 56212 56760 234779 320207 11852 19353 22324 20963 18710 19247 19354 14360 104709 22325 15170 106722 14127 243816 14726 57257 17096 16818 30955 18708 16822 18709 16797 18706 18607 INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 96%6783783 Interleukin-10 signaling 16451 16173 12519 12524 20303 20304 20293 20302 20297 16177 100039973 54721 16175 20299 16153 15945 14293 15894 19225 16193 330122 16181 16878 21857 14128 14825 21937 19204 21938 16178 16160 20848 16176 16159 16155 16154 21926 12985 12772 12768 12977 12774 12981 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%1222499 Latent infection - Other responses of Mtb to phagocytosis 17002 GSK3B AND BTRC:CUL1-MEDIATED-DEGRADATION OF NFE2L2%REACTOME DATABASE ID RELEASE 96%9762114 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 56637 667035 22190 18024 59029 67089 70247 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME DATABASE ID RELEASE 96%76002 Platelet activation, signaling and aggregation 320207 11472 20779 11651 22324 18710 26416 12928 18754 18755 320127 76192 26413 18787 104418 26417 14360 239273 56077 12988 66082 20416 231871 22325 380921 16002 110524 109905 16000 269060 110197 217480 13139 331374 14723 57257 54519 17096 20662 22371 16416 110157 16784 14161 21894 215449 21825 109689 216869 30955 18708 18709 110135 99571 18706 22330 18607 74769 109711 54216 11806 56760 11852 21390 19354 14673 640703 268373 19156 14674 19419 15234 22041 11820 72017 57349 18762 11848 14675 14697 14710 14699 66066 14700 14708 14706 14672 14704 14695 14676 22145 14693 64337 14709 14682 14701 19246 14724 268936 192176 54368 14729 14702 14696 56212 234779 23945 70839 20963 14678 14677 232345 14679 11657 20909 14688 68117 21857 14083 21803 21808 21809 242851 12331 18643 16438 16439 18441 12491 16440 12527 56744 14064 14062 14061 14065 667310 385643 18752 14828 11551 19128 11552 13645 11553 16822 14456 16797 22065 18751 22068 106722 26946 14127 243816 14726 18753 18783 16399 14268 11818 27359 12258 21346 56508 223864 20716 227290 18591 117586 11674 109232 71946 12759 215789 235505 67988 12321 11537 18613 26968 68038 20912 20911 21922 20255 108101 218454 223601 12512 19353 12927 80718 16426 22138 227612 60595 104009 320202 70945 53612 67059 20703 19247 18761 11625 21767 19395 19073 56541 74145 14067 104709 12631 14205 21832 17480 15170 80884 20344 21859 74840 94175 13041 22631 20363 11747 16427 18815 56193 18816 19039 56055 13601 240334 14069 20692 22388 75396 16818 22341 18407 22339 22340 11804 18750 71660 67072 66866 27999 GLYCOSAMINOGLYCAN-PROTEIN LINKAGE REGION BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1971475 Glycosaminoglycan-protein linkage region biosynthesis 76898 12111 121021 13004 15530 103978 218271 235534 14733 15529 11603 23888 20971 233781 217119 20969 14734 117592 67883 71951 20970 29873 215015 280645 13003 14735 72727 12032 13179 UCH PROTEINASES%REACTOME%R-HSA-5689603.4 UCH proteinases 22632 15161 56436 75302 17463 68837 57296 22223 20422 50933 26445 14479 17425 26446 71599 19172 228790 19173 19175 56207 19177 26443 26444 19170 66413 667035 22190 11461 59029 67089 70247 104416 621893 319162 15267 319173 218214 319163 319168 17131 319167 12021 108155 319176 56456 56505 21812 21813 225280 56249 69714 227195 109275 68142 18002 233875 70020 235134 319169 21762 22123 19179 19181 21803 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 110962 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451307 Activation of Na-permeable kainate receptors 14806 14805 AMINE OXIDASE REACTIONS%REACTOME DATABASE ID RELEASE 96%140179 Amine Oxidase reactions 17161 109731 212503 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.3 Signaling by ERBB2 KD Mutants 13866 59079 12539 13649 18183 83961 100042150 12223 18176 14388 20662 13874 15461 15200 211323 18803 13645 18708 18706 20416 15519 CO-INHIBITION BY BTLA%REACTOME DATABASE ID RELEASE 96%9927353 Co-inhibition by BTLA 208154 15170 230979 19247 CHAHP COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9940465 ChAHP complex assembly 319178 319183 319182 232440 319190 319149 319169 240442 11538 12417 12412 319176 107932 319181 15077 15267 78303 319188 319168 15270 319167 624153 319186 382522 RND1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696273 RND1 GTPase cycle 13836 14252 232906 56374 381293 20867 12389 83669 18844 108670 12874 11855 232339 109620 14786 223881 208994 108686 19249 66922 227937 20257 67586 71228 68187 93840 11671 327826 229658 226525 77480 269608 107971 218581 17063 18708 19655 18709 53382 22042 380664 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 96%428890 Role of ABL in ROBO-SLIT signaling 12331 11350 19876 11352 20563 76707 76499 67252 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674404 Sorafenib-resistant PDGFR mutants 18595 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME%R-HSA-199992.5 trans-Golgi Network Vesicle Budding 107338 15239 20404 75612 320634 20619 12874 117197 245638 27059 18457 224139 94245 80912 11777 170760 20615 21987 232946 20661 77929 67804 69178 68953 109689 11768 11769 11774 108012 11764 11765 11767 252903 233489 18704 22320 17113 14533 13423 20909 11840 66616 74325 15481 67489 20955 231580 11766 14325 11781 67602 108011 215890 74438 29816 105245 64138 13430 216705 11782 72685 108124 16004 14319 19345 67300 12757 22318 11820 22042 CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME DATABASE ID RELEASE 96%264870 Caspase-mediated cleavage of cytoskeletal proteins 14453 12367 11518 13169 18810 12368 227753 22352 12370 12369 20740 LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.2 LXRs regulate gene expression linked to gluconeogenesis 20181 20182 268903 22259 18534 DEFECTIVE ALG11 CAUSES CDG-1P%REACTOME%R-HSA-4551295.4 Defective ALG11 causes CDG-1p 207958 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 96%381119 Unfolded Protein Response (UPR) 270669 56494 12282 18044 13666 18045 12317 18046 20416 11910 56453 100037258 74126 14583 11518 21894 71853 20818 107513 68090 13665 78943 67204 77128 26427 22027 66362 208647 26905 109075 381801 66583 27362 27998 27053 72544 225849 12915 50911 320209 69639 78284 72662 64209 66446 22393 16905 227715 15191 74108 52639 72599 70640 13191 11911 192193 74322 12611 20293 71765 22642 28106 28146 75766 16006 231997 12751 56219 67398 228998 54616 12913 226641 52808 58193 105785 11370 11972 66515 69162 12608 13198 208677 606496 14828 67838 50907 LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME%R-HSA-9664535.2 LTC4-CYSLTR mediated IL4 production 13479 58861 14598 319446 70086 23887 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.6 Cyclin A:Cdk2-associated events at S phase entry 54124 56436 20459 17463 17187 75660 57296 20422 26445 26446 12575 19172 19173 211586 19175 13555 19645 19177 21781 21402 12567 26443 12443 11651 26444 12566 11652 19170 12447 66413 26965 56371 667035 27401 22190 12448 59029 12576 19646 67089 70247 66671 17869 17420 12572 12428 13559 104394 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 19651 26441 63955 22390 26442 72568 69077 23797 66997 12530 231506 23997 12531 629959 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME%R-HSA-5619115.5 Disorders of transmembrane transporters 117591 15275 16514 114479 269523 20495 20497 107723 19386 20928 12638 244373 228368 24060 445007 11806 13521 235504 18174 74591 53945 27413 11416 27421 20521 19300 69912 54403 20538 238384 103988 26569 246787 103468 22232 23985 72027 13487 20525 74104 20501 104245 234865 12215 21762 20516 22123 15203 18670 68421 28253 59015 19179 170441 69736 19181 71279 11666 19182 317750 23996 12870 24059 19184 110379 26440 19166 20533 19167 26441 26442 69077 20505 66997 142681 23997 20531 19743 56436 17463 57296 20422 26445 11998 26446 19172 54140 19173 26361 19175 12000 63993 236794 19177 331004 26443 26444 19170 12780 66413 667035 22190 214111 59029 67089 70247 20927 231103 20537 20526 13162 18400 170762 108989 226144 231042 227699 223921 227720 269113 66679 18141 107939 193670 69482 54197 71805 229782 54563 56774 19069 70377 70699 30962 20532 216440 72787 18226 218210 11303 20520 74338 20510 102680 66753 20512 20540 67819 246049 17254 116891 20338 216227 67470 27409 27410 U12 DEPENDENT SPLICING%REACTOME DATABASE ID RELEASE 96%72165 U12 Dependent Splicing 319322 107686 384091 666609 68705 20641 98053 101943 20638 81898 66420 69833 67710 245841 69920 67332 20022 192159 20020 231329 20021 69241 17749 100043714 66055 67197 107701 68092 72047 433702 20624 27366 225027 67996 22608 68879 320632 66125 66585 74351 20382 110809 67797 76167 22184 50996 78372 67225 67178 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME%R-HSA-1299316.3 TWIK-releated acid-sensitive K+ channel (TASK) 16527 223604 BETA DEFENSINS%REACTOME%R-HSA-1461957.3 Beta defensins 246082 12458 654460 654465 244332 629114 12772 77674 24088 654464 21897 266620 654459 75400 246700 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME%R-HSA-5609975.6 Diseases associated with glycosylation precursor biosynthesis 14635 227697 68563 74246 67422 319625 110119 50798 57357 14430 54128 14583 13480 72157 13481 52014 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME DATABASE ID RELEASE 96%9665250 Resistance of ERBB2 KD mutants to AEE788 13866 59079 12539 15519 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112122.3 ALKBH2 mediated reversal of alkylation damage 231642 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9702509 FLT3 mutants bind TKIs 14255 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181430 Norepinephrine Neurotransmitter Release Cycle 17161 233977 214084 20518 20517 19339 22318 20614 20979 68507 20907 327814 12889 22249 DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME DATABASE ID RELEASE 96%4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 15529 11603 23888 20971 12111 121021 13004 20969 15530 14734 117592 103978 71951 29873 20970 13003 14735 14733 12032 13179 HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.5 HDMs demethylate histones 214899 30841 67014 319149 225876 277250 22289 338523 20591 18676 320595 20592 244694 71371 76804 15077 107817 218214 230674 104263 99982 75605 216850 193796 ASSEMBLY AND RELEASE OF DENGUE VIRUS VIRIONS%REACTOME DATABASE ID RELEASE 96%9918476 Assembly and Release of Dengue Virus Virions 22608 22088 18550 68137 107338 216705 17096 SEMA4D IN SEMAPHORIN SIGNALING%REACTOME%R-HSA-400685.4 Sema4D in semaphorin signaling 13866 67268 67938 17904 11848 232906 11852 11853 17880 19877 17295 77579 19353 71960 20354 20130 16885 16886 223881 69632 17886 19878 213498 235611 DEFECTIVE DPM1 CAUSES CDG-1E%REACTOME%R-HSA-4717374.4 Defective DPM1 causes CDG-1e 13481 68563 13480 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 96%499943 Interconversion of nucleotide di- and triphosphates 67725 66422 320685 93692 18102 55936 18103 20133 20135 66588 78801 51797 21915 11636 11637 229949 635960 79059 56520 54369 382985 68870 14923 22171 50493 22166 JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 96%5689877 Josephin domain DUBs 269523 19358 19359 667035 66124 22190 50873 110616 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.8 Triglyceride biosynthesis 67800 14626 14933 68393 215456 14245 64898 13350 64899 14732 233549 SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.2 Sealing of the nuclear envelope (NE) by ESCRT-III 53857 22152 227613 105513 22153 22142 22146 116733 67951 71955 73710 224640 319965 22145 50850 100042651 66371 545486 68953 238463 75608 22147 22151 208092 66700 22143 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.4 Synthesis of dolichyl-phosphate mannose 13481 68563 13480 TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 96%168181 Toll Like Receptor 7 8 (TLR7 8) Cascade 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 100561 11909 26419 12675 71398 27056 16476 18033 18035 18036 11820 81897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 170743 14281 170744 12370 22030 12475 67245 225471 106759 18034 54123 434174 66513 93765 66589 22034 66724 68652 20111 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620922.5 BBSome-mediated cargo-targeting to cilium 12469 319757 12461 76260 319845 207911 12464 71769 52028 67378 93730 12465 102774 241950 71492 216363 72569 21454 12462 59030 20607 56297 PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.6 PI3K AKT activation 74769 16367 18211 11848 18049 18708 384783 18709 18706 SIGNALING BY NOTCH1%REACTOME%R-HSA-1980143.5 Signaling by NOTCH1 18011 232232 13388 16449 240055 225164 12805 20602 11487 54485 207521 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 21885 15213 56233 17869 15214 21886 227325 13386 21888 15251 74198 14357 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 109689 216869 16396 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 18222 15205 19664 433759 15182 TNFR1-INDUCED NF-KAPPA-B SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357956 TNFR1-induced NF-kappa-B signaling pathway 22030 11796 11798 16150 71648 16151 14694 53376 71609 66513 26409 66724 68652 12675 21937 30941 22029 229603 22258 268749 106025 21926 74256 263876 21929 24105 19766 11797 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.6 Autodegradation of Cdh1 by Cdh1:APC C 52717 56436 99152 17463 668450 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 56371 667035 22190 59029 67089 70247 21762 22123 19179 19181 19182 217232 23996 56317 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 BUDDING AND MATURATION OF HIV VIRION%REACTOME DATABASE ID RELEASE 96%162588 Budding and maturation of HIV virion 73711 22088 67123 330192 268373 76959 66201 20479 66914 66371 68953 105513 83814 75608 18571 667035 22190 107305 72543 208092 194309 66700 52348 116733 NUCLEAR EVENTS STIMULATED BY ALK SIGNALING IN CANCER%REACTOME%R-HSA-9725371.3 Nuclear events stimulated by ALK signaling in cancer 236511 19645 21402 56438 16364 20850 12047 16477 18148 217351 26965 214150 26413 26417 15170 13433 17454 12608 14939 20848 16154 667739 433759 14235 22160 18646 54167 232679 22637 76850 239528 PYRIMIDINE CATABOLISM%REACTOME%R-HSA-73621.4 Pyrimidine catabolism 230718 268782 50773 103850 22271 23959 64705 76654 72962 99586 103149 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME%R-HSA-428930.4 Thromboxane signalling through TP receptor 14708 14672 14706 14702 14704 14696 14695 14674 14676 14675 14693 64337 14709 14697 14682 14701 14710 14699 66066 21390 14700 227290 14688 PERK REGULATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%381042 PERK regulates gene expression 72544 50911 69639 72662 64209 66446 227715 74108 70640 18044 13666 11911 18045 18046 20293 12611 16006 226641 11910 12608 13198 14828 13665 67204 66362 26905 109075 66583 27998 27053 RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.4 RA biosynthesis pathway 20148 19378 237320 13082 98711 12903 56847 19682 11668 242285 105014 232174 216454 546726 17252 11522 108841 26876 241452 105349 28200 SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250347.5 SHC1 events in ERBB4 signaling 15461 15200 211323 18183 83961 100042150 12223 18176 20662 13874 20416 ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%2161517 Abacavir transmembrane transport 20518 20517 26357 20519 18671 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.5 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 29813 59092 13496 12428 12575 12427 13555 22059 12566 108961 12447 12448 12576 52679 MECHANICAL LOAD ACTIVATES SIGNALING BY PIEZO1 AND INTEGRINS IN OSTEOCYTES%REACTOME DATABASE ID RELEASE 96%9856532 Mechanical load activates signaling by PIEZO1 and integrins in osteocytes 20750 12293 16412 15530 12295 12296 12297 16410 11651 16416 14609 16402 18439 81904 55991 58226 ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%2029485 Role of phospholipids in phagocytosis 74769 246256 14131 18806 104759 16440 18753 234779 12502 53357 20963 18803 18754 381925 18805 18708 18807 18709 71910 229709 16438 14129 16439 18706 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 96%3304347 Loss of Function of SMAD4 in Cancer 17126 17127 17128 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%937042 IRAK2 mediated activation of TAK1 complex 68652 667035 22190 66513 26409 22034 108960 66724 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME DATABASE ID RELEASE 96%2995383 Initiation of Nuclear Envelope (NE) Reformation 23825 16211 12534 98386 22367 64383 224640 13726 12442 71978 71782 19052 51792 16906 380664 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 96%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 224105 78514 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME DATABASE ID RELEASE 96%114452 Activation of BH3-only proteins 209456 56455 211586 13555 22628 21781 11651 11652 22061 22062 12122 19057 171543 100039786 26419 54401 22631 55948 12015 22059 22629 19058 68097 21981 12043 22627 12125 23797 SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702624 sorafenib-resistant FLT3 mutants 14255 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 96%9032500 Activated NTRK2 signals through FYN 19353 18212 208869 20779 12064 14812 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-HSA-392451.5 G beta:gamma signalling through PI3Kgamma 104709 14708 14702 14706 11848 14704 14696 14695 320207 14693 64337 14709 11651 11652 14697 14701 14710 30955 14699 66066 14700 23797 14688 18607 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.7 Interleukin-12 family signaling 16451 16195 68981 16153 12330 56044 53379 98758 16160 16159 215449 667618 224105 16452 15978 66902 18453 54721 19188 11840 50931 12631 20955 50926 667310 66162 18569 12798 18738 268373 50498 12931 11632 20849 209590 12340 18826 17319 18788 12306 16162 20846 16161 246779 20848 15526 20656 21351 14873 21454 16906 17698 12346 DEFECTIVE GALK1 CAUSES GALCT2%REACTOME DATABASE ID RELEASE 96%5609976 Defective GALK1 causes GALCT2 14635 AGGREPHAGY%REACTOME DATABASE ID RELEASE 96%9646399 Aggrephagy 234663 56455 235661 21821 12638 68146 26369 68097 57320 269523 15185 667035 13427 22190 93765 50873 13426 66589 13424 18541 15499 15519 FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190370.4 FGFR1b ligand binding and activation 21814 67903 67112 14174 14165 14173 14164 INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 96%912526 Interleukin receptor SHC signaling 14389 74769 18707 16451 16453 18710 16186 16331 16332 16184 20416 16183 15170 20662 16188 16185 12984 12982 16192 16191 12981 18708 18709 16452 18706 VITAMIN C (ASCORBATE) METABOLISM%REACTOME%R-HSA-196836.4 Vitamin C (ascorbate) metabolism 14873 68214 109754 20525 109672 54338 20522 20527 O-LINKED GLYCOSYLATION OF MUCINS%REACTOME DATABASE ID RELEASE 96%913709 O-linked glycosylation of mucins 71685 26887 14426 20448 108148 171212 232984 353328 108105 241391 207839 72297 233733 94192 108150 212996 97440 654821 72077 271786 14537 67909 227327 53625 56336 56386 14425 269328 231727 230145 17829 14423 100039649 140474 224116 20446 17063 20444 59048 20442 20443 272411 231050 78754 20440 333424 210004 108760 73732 20447 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME%R-HSA-8949215.3 Mitochondrial calcium ion transport 78506 215999 11640 69029 234847 73078 110893 69597 66865 381038 66815 170756 68115 68514 12034 22334 66592 18673 22333 27377 216001 56384 22335 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME DATABASE ID RELEASE 96%1483248 Synthesis of PIPs at the ER membrane 83493 77980 67073 224020 77116 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME DATABASE ID RELEASE 96%111452 Activation and oligomerization of BAK protein 12122 12018 SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.3 Scavenging by Class F Receptors 15505 12282 12317 380713 238055 15519 MATURATION OF PROTEIN 3A%REACTOME%R-HSA-9694719.4 Maturation of protein 3a 14423 20448 20446 20444 20442 20443 20440 20447 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME DATABASE ID RELEASE 96%5339562 Uptake and actions of bacterial toxins 26400 26398 15200 18550 15519 640703 14917 170761 26395 26396 12527 56216 20980 64176 50493 18571 22317 64051 22318 20614 20979 20907 75209 13629 15516 ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME DATABASE ID RELEASE 96%139853 Elevation of cytosolic Ca2+ levels 269717 18438 26946 16440 109305 18436 228139 18440 94045 231602 18439 22065 22068 20866 16438 16439 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.2 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 56187 17988 19352 209456 22059 11799 12662 22061 66813 22062 21981 64058 12053 INTERLEUKIN-18 SIGNALING%REACTOME DATABASE ID RELEASE 96%9012546 Interleukin-18 signaling 16189 16163 16173 16174 16182 11689 16068 CHD3, CHD4, CHD5 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943965 CHD3, CHD4, CHD5 subfamily 216848 14377 232440 319149 240442 13445 11538 269610 12412 106795 107932 22780 22779 78266 228880 15077 52004 17191 233410 11819 22778 622675 70998 14121 19646 234366 245688 22196 23942 17192 15267 70802 101631 319168 73503 319167 229542 319186 319178 319183 319182 319190 319176 319181 116871 22026 116870 319169 12417 625328 78303 319188 15270 433759 15182 624153 18534 382522 REGULATION OF ENDOGENOUS RETROELEMENTS BY KRAB-ZFP PROTEINS%REACTOME%R-HSA-9843940.1 Regulation of endogenous retroelements by KRAB-ZFP proteins 216848 319178 319183 319182 232440 319190 319149 319176 107932 319181 15077 243834 232854 432769 21408 19646 234366 116871 12419 116870 21849 245688 319169 22196 54343 100043429 237758 23942 17192 625328 78303 15267 319188 15270 433759 319168 233060 431706 319167 244713 15182 624153 84505 229542 434178 319186 382522 INTERLEUKIN-7 SIGNALING%REACTOME%R-HSA-1266695.10 Interleukin-7 signaling 16367 16451 319149 20586 16453 20851 20850 15077 18710 16186 15234 20848 16197 216233 12700 93871 19373 19374 18708 384783 53603 12703 18709 16196 57914 KIDNEY DEVELOPMENT%REACTOME%R-HSA-9830369.1 Kidney development 16371 17300 13388 14573 16449 20472 279653 21410 20563 14234 12387 12159 15431 268902 15412 16869 18504 241226 18993 15396 14462 67701 114249 14173 13797 109663 22431 15403 15904 14585 23892 231507 18510 22412 16372 20471 22411 19713 16412 16848 22417 14013 15378 14048 58198 23967 Z-DECAY: DEGRADATION OF MATERNAL MRNAS BY ZYGOTICALLY EXPRESSED FACTORS%REACTOME%R-HSA-9820865.1 Z-decay: degradation of maternal mRNAs by zygotically expressed factors 208643 230594 214290 208718 218693 13682 192170 13681 75705 54196 18458 13684 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME DATABASE ID RELEASE 96%211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 224105 26441 26442 69077 66997 23997 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.4 Alpha-oxidation of phytanate 16922 26458 56794 111175 20524 ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME%R-HSA-168275.6 Entry of Influenza Virion into Host Cell via Endocytosis 67300 12757 OTC MAIN CHAIN VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956553 OTC main chain variants cause OTC deficiency 18416 DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 96%1489509 DAG and IP3 signaling 12326 19088 55984 19108 19087 19084 104110 12322 12323 108058 12325 18754 432530 210044 104111 229709 16438 16439 18747 100039592 640703 224129 16440 18753 11512 11513 110355 11514 18575 11515 18574 18573 18749 207565 18752 18803 18750 19085 DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME%R-HSA-5579026.4 Defective CYP11A1 causes AICSR 14149 14148 13070 68165 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%8849472 PTK6 Down-Regulation 20459 19246 20811 GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 96%1630316 Glycosaminoglycan metabolism 11881 18295 15931 76898 12111 121021 212898 13004 244757 114332 72297 14595 17022 78752 75612 192188 60322 269941 108902 218271 14264 545291 70484 27416 23908 15529 23888 20971 20969 54613 56398 15587 15442 50917 71951 20970 54371 71797 14735 12505 268512 231583 14043 14042 15531 15530 13521 27419 73836 56336 56386 103978 235504 74241 54616 58193 80982 14733 53374 83398 50786 77590 108652 93683 231727 14734 116847 319901 64580 117592 67883 59031 57370 53418 56375 215015 50787 15366 15118 15117 15116 72136 20544 58250 54710 628779 235534 50785 74468 11603 16545 233781 217119 227327 53625 15476 15478 27029 195646 17423 280645 56773 72727 234356 27047 29873 13003 338362 110006 76969 77042 15586 328779 20444 109685 23971 20442 70893 23972 20443 15212 319415 15211 78923 12032 13179 15932 12091 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 96%9005895 Pervasive developmental disorders 18747 81004 640703 20602 433759 12326 21372 56310 15183 20185 20466 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.6 rRNA modification in the nucleus and cytosol 72554 52705 230082 245474 223499 70683 100041622 233802 55989 66181 27966 100608 100040177 234374 68147 75416 57315 52530 14113 68979 14791 65961 622491 20115 76846 67134 72515 27993 217109 110816 68327 66138 208144 98956 67973 20044 18572 667279 78394 269470 59028 21771 110109 215193 217995 67674 73674 67755 213895 667739 216987 66254 66249 224823 102462 213773 105372 67205 DEFECTIVE ANO6 DOES NOT EXPOSE PS, PE ON THE PLATELET MEMBRANE%REACTOME%R-HSA-9853846.1 Defective ANO6 does not expose PS, PE on the platelet membrane 105722 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 17913 69940 22628 11651 66482 11652 20619 17886 56044 16568 100039786 53869 54401 55948 108099 20912 241113 17918 16579 17274 19353 53413 20909 20336 240028 68938 228850 19325 107371 68328 57915 20528 210789 640703 68365 74741 16569 22631 22629 108079 19079 105504 108097 19341 211446 102058 22318 22627 19082 TGFBR3 EXPRESSION%REACTOME DATABASE ID RELEASE 96%9839394 TGFBR3 expression 328572 233833 236511 20683 21423 213988 217351 214150 21406 20181 21413 17877 17454 17878 17927 17928 15201 17127 17128 18109 21814 118445 19401 76850 239528 GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70370 Galactose catabolism 14635 74246 319625 14430 72157 11677 DEFECTIVE MTR CAUSES HMAG%REACTOME DATABASE ID RELEASE 96%3359469 Defective MTR causes HMAG 210009 238505 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 96%433692 Proton-coupled monocarboxylate transport 57274 80879 20501 20503 13723 12215 REGULATION OF SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 96%1433617 Regulation of signaling by NODAL 269275 11479 11480 320202 620395 11481 23863 12622 18119 13590 PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME DATABASE ID RELEASE 96%1483196 PI and PC transport between ER and Golgi membranes 56305 LIPOPHAGY%REACTOME%R-HSA-9613354.4 Lipophagy 108097 108099 66905 19082 241113 108079 15481 11520 19079 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME DATABASE ID RELEASE 96%9637687 Suppression of phagosomal maturation 16211 233405 271457 667035 22190 12721 19349 18126 16646 15239 108664 POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME DATABASE ID RELEASE 96%2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation 20848 18999 99377 22773 100038891 13835 15221 620395 20674 58198 14173 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.5 Nef Mediated CD4 Down-regulation 11771 11772 71770 232910 11773 16818 11840 108664 12504 ALECTINIB-RESISTANT ALK MUTANTS%REACTOME%R-HSA-9717316.3 alectinib-resistant ALK mutants 11682 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME DATABASE ID RELEASE 96%2559582 Senescence-Associated Secretory Phenotype (SASP) 52717 99152 668450 232440 12575 319149 19697 12571 12567 12566 15077 56371 667035 22190 12576 26413 26417 110651 20112 77683 15267 319168 29817 319167 14281 319186 319178 319183 319182 12428 319190 110147 319176 319181 16175 23939 100043858 12580 12579 12578 16193 20111 319169 12427 12608 20848 217232 56317 625328 59008 16476 78303 18033 319188 66156 15270 216080 69957 17222 75430 68612 52563 624153 22194 68999 52206 100039535 382522 DAG1 CORE M2 GLYCOSYLATIONS%REACTOME%R-HSA-8932504.1 DAG1 core M2 glycosylations 13138 217734 68273 268510 99011 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%181429 Serotonin Neurotransmitter Release Cycle 233977 214084 27204 19339 22318 20965 20614 20964 20979 68507 20907 327814 12889 22249 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 96%5696394 DNA Damage Recognition in GG-NER 22632 26891 26754 56438 56456 26370 11545 56505 667035 225280 22190 26893 11461 56249 69714 227195 109275 26894 68142 11546 108679 233875 70020 19358 19359 235134 22591 107986 26572 26895 12848 99375 72584 100043806 13194 RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 96%5625740 RHO GTPases activate PKNs 12532 232440 11848 319149 22628 77579 76804 71960 15077 17886 67268 100039786 54401 11835 55948 263803 15267 319168 319167 18479 319186 18607 319178 319183 319182 67938 17904 319190 11852 17880 319176 319181 19353 17978 320795 109333 19046 99982 319169 22631 11853 22629 625328 78303 319188 15270 22627 329251 68458 17931 624153 382522 H139HFS13* PPM1K CAUSES A MILD VARIANT OF MSUD%REACTOME%R-HSA-9912529.1 H139Hfs13* PPM1K causes a mild variant of MSUD 12040 243382 13171 13382 12039 REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME DATABASE ID RELEASE 96%3371453 Regulation of HSF1-mediated heat shock response 193740 26413 26417 15499 72630 56354 50497 12017 81489 70356 67669 219158 19386 29810 18415 110920 67384 66538 70369 23950 15525 15505 17164 22791 73442 170762 108989 231042 227699 223921 227720 445007 269113 15512 66679 15482 18141 213539 107939 69482 71805 54563 19069 70699 72787 11920 18226 218210 56637 69912 93759 15481 68275 103468 68240 19891 234865 59015 69736 15526 110379 14828 22627 OTHER INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 96%449836 Other interleukin signaling 19152 12986 19283 242700 16451 20969 20911 12504 12367 54721 16155 12985 22318 20614 12977 12978 20907 16170 20909 20908 76527 109658 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 96%9610379 HCMV Late Events 319149 15077 107305 72543 27681 70160 194309 52348 116733 73711 22088 67123 330192 28084 19386 66914 66371 68953 621893 75608 234852 319162 15267 319173 319163 15387 319168 319167 170762 108989 231042 227699 208092 223921 227720 66700 445007 269113 319186 66679 18141 319178 319183 107939 319182 69482 12609 71805 319190 54563 19069 70699 319176 72787 319181 18226 218210 105513 69912 103468 319169 234865 59015 69736 78303 319188 110379 319189 382522 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70921 Histidine catabolism 76507 71761 107239 15186 15109 243537 140483 67383 14317 EICOSANOIDS%REACTOME DATABASE ID RELEASE 96%211979 Eicosanoids 320997 13120 106648 631304 100040843 13118 72054 208285 64385 21391 19223 13124 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME%R-HSA-5696397.3 Gap-filling DNA repair synthesis and ligation in GG-NER 68275 106344 72151 18971 68240 18972 59001 22594 19891 16882 18973 18974 19687 19718 69263 67967 66979 667035 16881 22190 27015 69745 18538 PREGNENOLONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%196108 Pregnenolone biosynthesis 100042622 14149 76205 14148 59045 12257 170459 20845 13070 11677 68165 ABC-FAMILY PROTEIN MEDIATED TRANSPORT%REACTOME%R-HSA-382556.7 ABC-family protein mediated transport 56436 17463 57296 20422 26445 26446 19172 19173 19175 17250 19177 16514 26443 26444 12780 19170 269523 66413 74610 667035 56199 22190 56325 224814 19299 59029 27403 27416 11305 67089 239273 224742 11304 70247 76184 77706 217262 192663 217265 27404 56535 26874 20928 12638 244373 19298 13665 67204 226144 26905 76408 193670 54197 11806 11307 70377 216440 18671 74591 27421 66753 67819 116891 20338 74104 21762 22123 18670 67470 19179 27409 19181 11666 27410 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 96%451306 Ionotropic activity of kainate receptors 110637 640703 14807 14806 13385 14805 52589 53310 13383 14809 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.4 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes 12447 12448 19645 12566 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME DATABASE ID RELEASE 96%5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) 20510 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 96%216083 Integrin cell surface interactions 20750 16456 320910 12550 16420 241226 17022 15896 109700 16398 16400 16403 12817 16404 11603 213119 107581 16408 16412 15898 12829 381924 12828 16407 12827 16409 12826 319480 22329 16421 21923 83964 12822 16423 16411 16399 14268 16416 12841 16414 78369 16401 67374 16402 14161 12840 15891 12845 21825 14118 22370 237759 12505 12839 110135 99571 18613 15530 16419 15894 12215 16410 16542 104099 ADIPOGENESIS%REACTOME%R-HSA-9843745.1 Adipogenesis 20602 23989 12567 59024 11450 327987 12445 11819 70625 68975 19646 234366 234959 94112 28077 70208 12491 245688 171285 17125 17128 23942 17192 56771 80509 67224 19014 229003 66999 16600 328572 12609 21372 109151 17977 19017 17978 59035 81004 66993 69790 26896 15183 20185 12914 20528 56406 108098 12608 18033 66172 170826 192191 78334 216848 12865 20933 19697 107932 20788 75613 381379 22410 12224 12606 20181 67219 19013 19016 21926 68910 13591 16846 18139 264064 13654 67544 230753 229542 76199 67279 57875 16956 70673 103968 22227 12683 12686 94187 116871 12162 17979 51810 216154 116870 22408 13592 51813 11770 69792 21803 67381 433759 15182 18534 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-HSA-6803211.2 TP53 Regulates Transcription of Death Receptors and Ligands 22062 209456 21981 21933 22059 16009 68742 14102 22061 DISEASES OF GLYCOSYLATION%REACTOME%R-HSA-3781865.4 Diseases of glycosylation 66548 18295 13138 330267 207596 12111 224697 121021 227619 56229 13004 353328 239337 68273 77794 14595 94192 279028 17022 269941 108902 218271 14264 15529 23888 20971 14635 227697 74246 319625 20969 19025 50798 57357 14430 14583 13480 13481 71951 20970 207958 21825 14735 52014 66789 14043 68563 14042 67422 18010 15530 13521 103978 14733 53374 14734 116847 117592 18129 18131 18128 18132 72136 11603 16545 72157 56773 72727 27047 56737 320438 208624 102580 24070 208211 381903 13478 328370 108153 23794 30806 108154 16795 210417 271127 229595 208936 77739 381694 269959 14425 269328 230145 100689 110119 233744 235130 240322 20357 57377 54128 16848 11504 20356 17829 18636 100039649 21826 140474 29873 217664 224116 13003 226866 217734 17063 59048 240913 23972 223838 15212 99011 15211 237360 12032 330119 13179 216725 73732 12091 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME%R-HSA-5683177.4 Defective ABCC8 can cause hypo- and hyper-glycemias 16514 20927 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME%R-HSA-2206285.5 MPS VI - Maroteaux-Lamy syndrome 11881 FORMATION OF DEFINITIVE ENDODERM%REACTOME%R-HSA-9823730.2 Formation of definitive endoderm 12387 13813 12767 21416 12550 20671 20997 14836 15376 27217 14465 17126 17127 17128 14463 SARS-COV INFECTIONS%REACTOME%R-HSA-9679506.7 SARS-CoV Infections 71164 53618 16451 20448 56208 227619 66383 19089 67443 13200 208884 58194 78610 22628 12389 11651 11652 22324 269523 18566 19646 234366 245688 100042069 54401 23917 55948 20662 19877 233870 23942 19878 378425 218978 16452 218035 15516 18607 328572 66357 22154 269338 16172 18550 69550 18024 22365 66101 19035 80743 12914 28185 268373 71586 230073 66641 71956 14225 18521 228607 217069 12695 20817 224912 20815 56217 77573 14609 22627 24088 21897 93687 216848 257630 56480 20683 54131 66397 58203 171095 56438 107932 69608 15006 218811 99683 240095 18148 667803 23881 27041 14991 77371 100039786 20334 19712 16412 20390 15382 66371 68953 75608 12362 12785 228545 170762 108989 16396 231042 208092 227699 223921 229542 66700 227720 19766 269113 67197 66679 56532 18141 107939 69482 71805 73158 54563 71732 234779 53902 19069 70699 72787 16453 18226 16177 218210 105513 11771 54721 11772 20963 50724 60406 71770 13609 233405 12229 20847 64685 15980 17060 15979 58799 12518 228005 99982 217864 14228 15985 27207 15975 67097 94246 670832 18391 100041953 633683 13207 110606 16171 20044 26554 71954 27050 107392 667279 14272 20085 232910 238247 668144 11773 15353 20084 382492 20055 75617 100043508 27370 629957 20102 20103 668668 667739 66481 225058 100038875 11931 58861 17973 16785 11932 11933 66824 216799 18186 19645 56188 100038882 12330 15519 15529 100039316 11928 23888 98660 20971 16211 232975 100039592 57780 19386 20969 59095 108017 20115 17127 17128 76846 100040298 17192 71951 20970 14735 267019 445007 67941 57294 15530 50528 70008 171283 103978 14733 69912 103468 15977 14734 234865 12675 59015 69736 18033 110379 12846 18035 12048 75669 81897 225326 107686 19697 384091 666609 216766 16150 621705 21872 20595 16151 66603 53975 192656 276919 20641 16179 667035 20638 225913 22190 69731 432803 26409 16194 67332 67089 257632 11603 107607 101772 14815 108960 22196 16401 102566 404545 170743 15007 12010 170744 105722 382014 17195 320091 22031 56489 233246 20014 72512 54123 57261 103963 243634 56637 66513 69038 93765 66589 13135 19247 22034 116871 66724 116870 68652 15170 50868 15469 22631 103534 67075 57377 22629 27801 228136 20846 75965 70546 108687 14423 269181 214424 57437 328417 217664 606496 69035 67287 433759 107895 80285 20446 52552 20444 671535 22346 20442 547253 80286 20443 17308 17158 15182 68292 20440 23797 67569 16430 14376 20447 MINERALOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%193993 Mineralocorticoid biosynthesis 12640 13072 15492 15497 16866 13079 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 96%9031525 LXRs regulate gene expression to limit cholesterol uptake 22260 20181 20182 218203 22259 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 96%181431 Acetylcholine binding and downstream events 11438 110834 11449 110902 11435 11448 11447 11440 108015 108043 11444 110835 231252 SARS-COV-1-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9692914 SARS-CoV-1-host interactions 16785 56480 20683 54131 66824 216799 22628 19697 12389 18148 667035 225913 22190 67089 100039316 16211 100039786 100039592 20390 54401 15382 55948 20115 17127 108960 17128 76846 22196 100040298 12362 170743 16396 267019 67941 18607 56532 328572 57294 22031 56489 53902 72512 64685 69550 66101 19035 228005 22034 27207 67097 670832 633683 28185 20044 27050 667279 268373 20085 668144 20084 382492 20055 22631 71586 75617 230073 27370 22629 66641 18521 14225 629957 228607 20102 217069 20103 56217 668668 667739 18033 18035 22627 66481 225058 100038875 12048 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 96%392170 ADP signalling through P2Y purinoceptor 12 14708 14706 14702 14704 14696 14695 14693 70839 64337 14709 14697 14678 14677 14701 14679 14710 14699 66066 14700 242851 14688 RRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72312 rRNA processing 66362 109075 66583 27998 72544 50911 69639 72662 66446 227715 104318 110109 27373 24128 67134 27207 67097 670832 633683 20044 27050 667279 20085 668144 68626 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 55989 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 56200 72515 67676 27993 102614 50912 67619 66878 217109 110816 68327 66138 229504 208144 98956 67276 67973 18114 18572 78394 53414 216156 269470 59028 12181 21771 75273 215193 64934 217995 67674 73674 67755 68272 213895 76130 216987 66254 66249 353258 56095 71340 224823 102462 69072 213773 105372 67205 72554 104662 67053 52705 230082 245474 223499 269536 80886 70683 100041622 97961 233802 66164 66181 27966 57750 74035 100608 100040177 234374 68147 667035 30877 75416 57315 52530 14113 68979 208366 227522 14791 57316 67045 54364 72198 65961 622491 68533 72181 52575 75619 227682 83485 94254 224481 66132 66410 67390 217038 15108 69821 71989 101122 68017 GSD IV%REACTOME DATABASE ID RELEASE 96%3878781 GSD IV 232493 74185 ATTACHMENT OF BACTERIA TO EPITHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9638630 Attachment of bacteria to epithelial cells 109637 17075 REGULATION OF PD-L1(CD274) TRANSLATION%REACTOME DATABASE ID RELEASE 96%9909620 Regulation of PD-L1(CD274) translation 233833 213988 60533 236511 217351 17454 214150 76850 239528 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669935 Signaling by juxtamembrane domain KIT mutants 16590 PLATELET AGGREGATION (PLUG FORMATION)%REACTOME%R-HSA-76009.4 Platelet Aggregation (Plug Formation) 20779 11651 14061 12927 20963 12928 19395 12988 20416 21832 109905 17480 19419 14723 54519 20662 22371 16399 14083 14268 16416 14161 21894 215449 19246 11551 11552 56508 11553 223864 14724 110135 54368 99571 14729 18607 SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.3 SHC-related events triggered by IGF1R 15461 16002 16000 16001 18176 20662 EPH-EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%2682334 EPH-Ephrin signaling 11848 11487 216963 14810 22612 77579 71960 16885 16886 17886 11461 14360 15529 22325 67268 545156 16443 57257 17096 19877 19164 19165 15461 100042305 208117 11465 59287 100039623 19878 224105 18479 110596 13836 67938 17904 17395 18481 17880 76709 19353 73178 53378 11771 11772 71770 56443 53972 74325 68089 67771 13848 54126 12631 11867 13846 13845 56378 270190 13842 66713 13840 232910 74117 17390 11773 13841 13839 13838 13837 13637 13636 14812 13643 13642 218397 21844 14083 13641 13640 13639 13844 13638 17974 67300 13429 13835 12757 REGULATION OF ENDOGENOUS RETROELEMENTS BY PIWI-INTERACTING RNAS (PIRNAS)%REACTOME%R-HSA-9845323.1 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) 216848 232440 319149 67155 20586 20588 20587 107932 70127 29861 269397 15077 19708 268996 12055 12054 11461 77045 19646 234366 330890 13435 245688 23942 68094 17192 83796 83797 15267 57376 319168 319167 229542 319186 319178 319183 319182 319190 239985 319176 56456 319181 66993 116871 116870 93760 319169 625328 54427 78303 100039610 319188 622480 15270 433759 15182 624153 382522 SIGNALING BY NOTCH%REACTOME%R-HSA-157118.7 Signaling by NOTCH 233833 232440 12805 20602 11937 11938 319149 14595 211586 53313 13555 66894 21781 79221 11651 12443 270118 15077 13557 15213 56233 17869 50721 15214 13649 13710 54613 15251 17127 76580 109689 216869 103806 328572 21372 333639 81004 18550 15183 20185 12914 22608 14534 21762 22123 19179 19181 19182 23996 19184 19664 16476 26440 19166 19167 13645 19346 26441 26442 69077 66997 23997 18011 56436 13388 232232 17463 16449 57296 240055 20422 225164 26445 11487 26446 54485 19172 207521 11491 19173 16450 19175 18129 18131 19177 18128 21402 18132 56438 26443 26444 19170 18759 170787 66413 26965 667035 22190 59029 67089 70247 21885 21886 227325 22059 13386 21888 14128 74198 208727 14357 19164 14939 19165 15208 100042305 208117 15267 59287 100039623 319168 56198 319167 264064 16396 76850 239528 319186 319178 319183 319182 236511 319190 18514 218977 67784 319176 19208 211652 21335 50701 319181 213988 217351 15185 214150 70315 15184 12140 51813 17454 20338 319169 22631 18519 16848 18222 15205 20846 625328 78303 319188 15270 433759 17242 14257 19719 20443 17305 224143 624153 140484 15182 100042343 382522 P75NTR REGULATES AXONOGENESIS%REACTOME%R-HSA-193697.3 p75NTR regulates axonogenesis 18053 11848 192662 109904 18049 17136 68585 18377 235402 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME DATABASE ID RELEASE 96%5579022 Defective GGT1 causes GLUTH 14598 ESSENTIAL FRUCTOSURIA%REACTOME DATABASE ID RELEASE 96%5657562 Essential fructosuria 16548 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME%R-HSA-77350.3 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 15107 97212 231086 11409 93747 DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.4 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) 20501 12215 SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.4 Signaling by NTRK1 (TRKA) 21990 56437 14066 17095 12570 20393 15902 15901 23938 17172 54152 20408 15903 14283 211770 16478 17936 17937 20404 11838 13656 13655 381677 107746 103967 109880 12929 26416 12928 56044 64143 18049 216148 26413 26417 29857 20416 327826 18211 109905 77480 19094 20418 102626 19730 54401 73699 26415 26395 26396 19762 110651 18176 20112 20662 19769 15461 17164 19052 19053 51792 18708 18709 18706 328572 74769 21770 13712 15904 16477 17260 17261 23939 11909 13430 18212 18803 12569 12568 384783 16367 11848 73086 107932 17258 11540 21406 19712 11516 11517 100040260 101568 235584 67603 319520 72349 14281 13654 20807 14282 13653 11771 11772 71770 20111 232910 11773 20848 67300 13429 12757 NEDDYLATION%REACTOME%R-HSA-8951664.7 Neddylation 50933 19823 71599 330369 269523 24108 102323 54638 50788 140858 100737 73828 66199 56468 230796 415115 80913 213464 27784 114893 54607 99311 71991 28199 230903 74106 66772 78309 208372 76863 76454 245688 240263 66498 52245 98193 65247 434130 17846 65255 15251 320808 79043 66200 67731 14155 53417 142687 76501 242418 78910 69456 59043 65256 12848 14154 70392 216233 12238 12700 68842 66398 75763 233805 234664 225055 74251 232539 100043806 26891 231670 69754 77113 12702 207952 320118 30843 68854 76294 72323 399566 18024 214931 18002 67923 106052 242960 30838 71902 30050 50762 56438 50754 71833 213980 68628 50789 217365 30839 22230 26554 211255 71745 99375 72584 13194 76843 12575 66105 27401 11799 75221 18412 68350 26893 224111 26894 108679 107986 26572 21762 22123 26895 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 223499 19172 19173 19175 72345 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 67089 103583 70247 117589 78541 69299 233902 50760 235320 242521 209239 74492 72194 69706 217194 226541 65257 242785 26374 211949 26754 233040 231672 231863 101358 12449 224023 12189 71538 67455 14794 100041766 217217 71999 269529 83962 230654 635668 13819 66515 269514 78889 68431 230904 71865 380928 50868 233826 207215 22200 627648 75717 67921 22192 142688 243574 74646 216080 448987 22346 228003 212919 71393 POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%110362 POLB-Dependent Long Patch Base Excision Repair 11545 18970 14156 11792 16881 26430 100206 11546 PHASE 0 - RAPID DEPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576892 Phase 0 - rapid depolarisation 14169 235281 14168 14167 14166 20266 20265 56808 12295 12296 20271 399548 20272 20274 12322 20273 12323 108058 110876 12325 20269 81904 72821 110880 20264 640703 54377 24046 81905 54378 12288 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME%R-HSA-4570464.4 SUMOylation of RNA binding proteins 18141 107939 19763 69482 71805 54383 54563 13619 19069 70699 55989 241915 72787 12416 18226 218210 19821 69912 103468 19386 234865 30951 59015 15381 22196 12418 69736 100043429 110379 15387 170762 108989 231042 227699 223921 227720 445007 269113 12151 66679 22658 DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME%R-HSA-5679090.4 Defective ABCG8 causes GBD4 and sitosterolemia 67470 27409 PROLACTIN RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 96%1170546 Prolactin receptor signaling 12234 20850 14600 19116 26965 19247 21402 56438 16452 19109 20851 NFE2L2 REGULATES PENTOSE PHOSPHATE PATHWAY GENES%REACTOME%R-HSA-9818028.2 NFE2L2 regulates pentose phosphate pathway genes 14381 12914 328572 21351 17134 21881 18024 110208 REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.3 Regulation of gene expression in early pancreatic precursor cells 246086 19213 21410 18096 18609 15379 14165 SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 96%69239 Synthesis of DNA 52717 99152 668450 12566 12447 56371 27401 16881 12448 12428 109145 17216 272551 17215 17217 17218 17219 17220 78833 12544 69270 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 56436 17463 67177 57296 23834 20422 26445 14156 26446 57441 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18969 18968 19075 19076 69745 327762 59001 19687 19718 69263 66979 50793 18392 18393 66634 26428 26429 56452 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 67967 217232 56317 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%977068 Termination of O-glycan biosynthesis 20448 269328 353328 17829 100039649 140474 224116 20446 17063 20444 20442 20443 20440 73732 20447 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.5 RNA Polymerase III Transcription Termination 70408 20018 69870 70428 18027 17749 218832 18029 100043714 67005 20823 20016 18032 12909 67065 74414 66420 69833 78929 245841 26939 67486 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 96%140342 Apoptosis induced DNA fragmentation 16211 80838 13368 13347 16646 97165 12367 434174 56702 50709 14957 50708 14958 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 96%5685938 HDR through Single Strand Annealing (SSA) 12021 81601 327762 19361 22427 19718 69263 15574 11920 12189 235610 231724 237911 19355 16881 225182 26909 235559 12144 13870 68275 11350 106344 72151 19365 68240 19891 50505 19367 19356 19360 17535 21975 27354 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 96%416550 Sema4D mediated inhibition of cell attachment and migration 19353 20354 20130 11848 223881 232906 17295 235611 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654733 Negative regulation of FGFR4 signaling 14172 80857 14170 14180 12402 14177 24064 64654 17346 14175 14173 14164 83379 109880 667035 22190 19247 26413 26417 327826 19052 19053 51792 80903 14186 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME%R-HSA-9659787.2 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 12448 12577 12576 G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.5 G1 S-Specific Transcription 75660 67177 12534 23834 211586 13555 21781 67141 12544 18392 12447 20135 19646 18538 50496 13559 104394 18968 12427 22171 21877 13361 433759 19650 19651 72568 231506 629959 MET RECEPTOR ACTIVATION%REACTOME%R-HSA-6806942.5 MET Receptor Activation 20733 20732 15451 54426 15234 17295 FORMATION OF THE ANTERIOR NEURAL PLATE%REACTOME DATABASE ID RELEASE 96%9823739 Formation of the anterior neural plate 14472 18999 18508 24136 225207 100038891 18991 18424 20664 20674 22772 BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 96%73884 Base Excision Repair 232440 14156 17193 234258 71726 11545 382913 18294 72774 16881 18207 28113 15267 101185 319168 319167 69745 26430 100206 319186 319178 319183 319182 18970 59001 11792 319190 22594 16882 57321 19687 19718 319176 69263 319181 59047 66979 319152 21749 497652 21750 18538 11546 68275 106344 72151 18971 68240 18972 19891 319169 18973 18974 268395 67967 78303 319188 15270 624153 382522 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME DATABASE ID RELEASE 96%3656243 Defective ST3GAL3 causes MCT12 and EIEE15 18295 16545 14264 116847 17022 27047 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.6 Resolution of D-loop Structures through Holliday Junction Intermediates 12021 224008 60530 81601 327762 20422 19361 114714 209334 22427 11920 12189 12190 237911 57434 225182 74335 26909 71711 12144 381306 233826 19362 268465 52864 19360 17535 21975 19363 19364 27354 FATTY ACIDS%REACTOME%R-HSA-211935.6 Fatty acids 320997 13087 13120 13107 631304 13118 72054 208285 13088 64385 56448 11529 13110 106648 100040843 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO OPN1LW LOSS OF FUNCTION%REACTOME%R-HSA-9918450.1 Defective visual phototransduction due to OPN1LW loss of function 14539 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.4 Voltage gated Potassium channels 240444 238076 225030 16535 16538 16539 16497 60613 16512 98741 66733 380728 240595 16490 16491 226922 16492 192775 16485 170738 16506 16504 99738 16493 16494 16498 16495 242151 16500 16502 268345 16508 56543 382571 241794 16510 211468 16511 16499 67498 16536 238271 110862 CPS1 VARIANTS CAUSE CPS1 DEFICIENCY%REACTOME%R-HSA-9955542.1 CPS1 variants cause CPS1 deficiency 227231 NFE2L2 REGULATING MDR ASSOCIATED ENZYMES%REACTOME DATABASE ID RELEASE 96%9818032 NFE2L2 regulating MDR associated enzymes 76408 12914 328572 27407 26357 18024 17250 17135 VRNP ASSEMBLY%REACTOME%R-HSA-192905.5 vRNP Assembly 70572 15519 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 109905 20779 54519 20662 22371 14083 16399 14268 16416 14161 21894 215449 110135 99571 INTERLEUKIN-9 SIGNALING%REACTOME%R-HSA-8985947.8 Interleukin-9 signaling 16198 20850 20848 16199 16451 16186 20846 16453 20851 GSD IA%REACTOME%R-HSA-3274531.4 GSD Ia 14377 DEPURINATION%REACTOME DATABASE ID RELEASE 96%73927 Depurination 319178 319183 319182 232440 319190 57321 319176 319181 234258 319152 18294 21749 497652 21750 319169 268395 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME DATABASE ID RELEASE 96%2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 12534 18817 59125 12442 59126 217718 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 96%68689 CDC6 association with the ORC:origin complex 50793 18392 23834 18393 66634 26428 26429 56452 MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 96%72200 mRNA Editing: C to U Conversion 11810 80287 11811 69865 71281 SIGNALING BY FGFR1 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655302 Signaling by FGFR1 in disease 14389 80857 110279 14180 14177 64654 14175 14173 20851 14164 20850 75296 360013 432508 67529 13047 76007 14182 327826 67384 18176 14388 20846 20662 20848 244373 15461 18803 21848 18708 18706 CIPROFLOXACIN ADME%REACTOME DATABASE ID RELEASE 96%9793528 Ciprofloxacin ADME 20517 26357 11657 19879 28250 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 96%156587 Amino Acid conjugation 435528 107146 233799 233801 272428 117147 SDK INTERACTIONS%REACTOME DATABASE ID RELEASE 96%373756 SDK interactions 330222 237979 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.10 Pyruvate metabolism 14874 17436 18563 667035 22190 13382 22333 107029 27418 70456 74125 16833 226757 56705 76282 109801 16832 381511 68263 228026 18604 236900 27273 68477 75387 18004 66089 27402 68636 106557 18597 18598 382051 319518 16828 66771 55951 76425 59003 109264 235339 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME DATABASE ID RELEASE 96%1307965 betaKlotho-mediated ligand binding 83379 14170 14186 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 96%112313 Neurotransmitter uptake and metabolism In glial cells 105727 20511 14645 20512 REGULATION OF TBK1, IKKΕ-MEDIATED ACTIVATION OF IRF3, IRF7 UPON TLR3 LIGATION%REACTOME DATABASE ID RELEASE 96%9828211 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation 56480 667035 22190 22031 56489 106759 21353 71648 142980 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-HSA-1834941.5 STING mediated induction of host immune responses 56480 446099 54131 207521 20821 19090 22040 72935 72512 20852 268857 22596 14375 214763 17535 DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.3 Drug resistance of PDGFR mutants 18595 VXPX CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 96%5620916 VxPx cargo-targeting to cilium 107371 69940 53869 107338 18763 18764 17274 66482 105504 215445 216363 211446 53413 102058 13196 212541 233649 12789 11843 20336 CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME DATABASE ID RELEASE 96%2219530 Constitutive Signaling by Aberrant PI3K in Cancer 14389 77647 16367 18213 14172 80857 14170 14180 268980 14178 18183 14177 320207 83961 67112 20779 100042150 64654 14175 14174 17295 14173 14164 22324 83379 18710 13983 14255 14360 327826 13982 13649 21802 18595 30955 12478 18708 18709 18591 18706 74769 18707 12487 12519 12524 56212 12223 71920 13874 19353 15200 211323 14256 19247 19354 104709 13866 12064 14388 15234 18212 18205 78405 11839 16818 16590 13645 80903 384783 14186 14165 83490 18596 SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.6 Signaling by SCF-KIT 14389 21682 16923 17395 17228 19273 71520 14159 14158 23921 12402 14783 22612 20851 19353 22324 20850 14786 18710 19247 14360 54607 15170 17096 18176 20846 20662 20848 15461 12649 17444 16590 16818 18750 18708 12703 18709 16452 18706 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.5 Cell Cycle Checkpoints 52717 99152 29870 668450 12534 22628 70620 26416 240087 12545 19094 54401 55948 17216 17215 17217 17218 17219 103573 17220 12544 22627 22390 12530 27373 93687 208583 12532 23834 268930 56438 100039786 22059 50793 18392 18393 66634 26428 26429 56452 12575 12566 12447 12448 12576 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 73804 19053 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 17248 72155 26931 21770 26932 12428 70385 17246 57294 56455 226747 17120 26951 108000 229841 12237 12617 107995 72415 83815 12615 319152 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 12578 18472 67733 103468 66468 76464 66442 67629 235661 12427 56430 234865 56150 21762 12442 22123 60411 66336 59015 19179 69736 19181 67052 19182 232987 23996 12236 19184 236930 110379 26440 69928 19166 13427 76499 19167 13426 26441 52504 13424 26442 228421 69077 66997 23997 12234 56436 27214 17463 57296 20422 26445 26446 19172 70024 19173 19175 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 107823 67089 68251 103583 20184 70247 269582 70681 70238 27223 12795 107976 210766 59004 15204 19360 17535 21975 319186 27354 319178 12021 29813 319183 59092 319182 26374 81601 50883 327762 228829 319190 22427 19718 69263 15574 11920 319181 12189 235610 231724 237911 19355 56637 225182 93765 26909 235559 12144 68275 106344 72151 68240 19891 22631 19367 19356 22629 12649 217232 56317 59008 78303 18817 319188 66156 15270 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 382522 INITIATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769735.1 Initiation of coagulation cascade 15529 11603 14067 23888 20971 14066 20969 15530 14734 11905 14068 22371 14061 103978 71951 20970 14069 19128 14058 14735 14071 14733 MPS IV - MORQUIO SYNDROME B (CS DS DEGRADATION)%REACTOME%R-HSA-9953111.1 MPS IV - Morquio syndrome B (CS DS degradation) 12091 MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.5 MPS IIID - Sanfilippo syndrome D 75612 GSK3B-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9929356.1 GSK3B-mediated proteasomal degradation of PD-L1(CD274) 12234 56436 17463 57296 20422 26445 26446 19172 26754 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 56637 667035 22190 59029 67089 70247 21762 22123 19179 19181 19182 18005 23996 19184 26440 60533 19166 19167 26441 26442 69077 66997 23997 GAP JUNCTION DEGRADATION%REACTOME DATABASE ID RELEASE 96%190873 Gap junction degradation 14609 67300 13429 17920 11773 12757 13430 13132 74325 AMYLOID FIBER FORMATION%REACTOME%R-HSA-977225.8 Amyloid fiber formation 20437 16334 11487 319149 106039 21810 68396 12307 11816 56224 69592 13010 15077 20219 67847 16432 20660 667035 23821 227753 22190 232670 51788 17304 230899 22139 20210 52588 70423 15874 100042305 208117 14161 59287 15267 100039623 319168 319167 12010 50873 17002 319186 319178 319183 319182 56791 319190 15530 11806 22284 319176 319181 20617 18550 11808 319169 625328 78303 319188 15270 74105 260302 11820 624153 20439 19109 382522 GSD 0 (MUSCLE)%REACTOME%R-HSA-3828062.5 GSD 0 (muscle) 14936 27357 MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.2 MET activates RAS signaling 15461 56705 224116 18176 74334 15234 20662 17295 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.3 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 29813 328572 12532 104394 12534 211586 15469 22059 55948 21781 13197 20878 59035 12028 19650 19651 18538 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 96%5685939 HDR through MMEJ (alt-NHEJ) 12190 11545 19365 14156 22594 19360 225182 16882 17535 77782 11546 27354 MMR%REACTOME%R-HSA-5358508.3 MMR 17685 68275 17686 17350 17688 18971 68240 18972 19891 67967 16881 69745 26909 18538 18861 DOPAMINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390651 Dopamine receptors 13489 13488 13492 13491 13490 SCAVENGING BY CLASS H RECEPTORS%REACTOME DATABASE ID RELEASE 96%3000497 Scavenging by Class H Receptors 20692 238055 192188 192187 DEFENSINS%REACTOME DATABASE ID RELEASE 96%1461973 Defensins 22072 246082 12458 654460 654465 244332 629114 12504 12772 77674 24088 654464 21897 266620 654459 75400 11870 246700 POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%2892245 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation 18999 100038891 20674 OPSINS%REACTOME DATABASE ID RELEASE 96%419771 Opsins 13603 57811 14539 212541 12057 20132 353344 30044 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.4 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) 20521 PEPTIDE HORMONE METABOLISM%REACTOME%R-HSA-2980736.5 Peptide hormone metabolism 18508 17228 69940 16334 12387 245049 66482 14607 22226 22094 11891 12640 104158 13809 16000 16572 16573 12922 69048 14695 57394 14943 16574 234155 18548 27226 64337 17380 12876 12038 16790 76703 16326 11423 12873 70495 11421 100038824 16325 16324 16846 239436 12591 225642 18549 236781 13482 67475 16600 11606 66624 21416 14526 56373 70008 66286 17918 18453 16866 14463 53413 13033 76687 20336 107221 69019 14308 14688 107371 64138 233081 56529 16323 16322 105504 211446 18976 16392 102058 22318 13035 20907 242851 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME%R-HSA-165054.4 Rev-mediated nuclear export of HIV RNA 18141 107939 69482 71805 54563 19069 70699 72787 103573 18226 218210 69912 103468 19386 234865 59015 69736 110379 19384 170762 100088 108989 231042 19385 227699 223921 227720 445007 269113 66679 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME DATABASE ID RELEASE 96%422085 Synthesis, secretion, and deacylation of Ghrelin 16600 16000 66624 12922 16334 14526 66286 234155 56529 18548 27226 12038 11423 22226 16846 76687 69019 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME%R-HSA-171286.3 Synthesis and processing of ENV and VPU 18550 GSD IB%REACTOME%R-HSA-3229133.4 GSD Ib 14385 DEFECTIVE GCLC CAUSES HAGGSD%REACTOME%R-HSA-5578999.4 Defective GCLC causes HAGGSD 14629 14630 TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-168898.11 Toll-like Receptor Cascades 103967 66105 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 13038 17087 21770 13039 26399 238055 26400 26398 26420 13712 26414 26397 17260 21898 23939 100561 20201 20202 11909 26419 13430 12675 216238 71398 27056 78287 16476 18033 18035 18036 24088 11820 21897 75669 81897 12234 56480 54131 225326 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 53791 107607 21899 69721 231130 93834 270151 16409 11596 22059 67454 240518 71966 108960 59025 100040260 16414 101568 235584 67603 319520 72349 170743 13040 14281 19141 170744 13030 22027 12370 54445 142980 19766 17079 11797 16803 56532 329547 17084 22030 19258 12475 22031 67245 56489 234779 69146 225471 11796 106759 21353 18034 71648 54123 54722 12229 434174 100041766 14082 66513 93765 66589 19247 22034 66724 68652 20111 13429 216080 12703 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 96%8856825 Cargo recognition for clathrin-mediated endocytosis 58194 20408 12402 56324 15239 20404 20844 20405 13858 13649 12500 21802 12502 12638 12504 12848 109689 216869 100043806 26891 11607 238055 12223 71920 13874 20508 15200 21336 22320 26893 17113 74325 26894 20955 18002 108679 26572 26895 16004 20980 22041 11839 22318 20979 13645 22042 11998 53330 11555 12000 22319 667035 22190 243764 16443 110355 100017 26754 13132 73094 14366 229521 194590 210108 233489 22418 11771 218503 11772 30931 71770 30934 74015 13854 108800 20616 20403 13855 67602 15463 232910 56017 11773 16835 13859 320129 12492 60510 269774 13543 14725 16197 55925 66147 67300 54609 12757 56085 ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 96%1169092 Activation of RAS in B cells 15461 19419 240168 18176 PD-1 SIGNALING%REACTOME%R-HSA-389948.6 PD-1 signaling 233833 16451 21415 232440 12387 13200 13626 319149 72297 22628 16478 16842 12567 12443 15077 269523 66310 140858 97064 18566 52615 19646 213464 12988 11910 214162 13001 13000 100039026 17869 245688 20747 12500 22601 12501 12502 15251 23808 12504 18109 244373 18005 60533 76580 108099 16362 328572 66357 21414 21416 231051 18024 12914 21762 22123 19179 19181 19182 23996 19184 16476 18033 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 21679 15267 21676 319168 21678 319167 14281 226144 76850 239528 319186 21677 319178 319183 319182 193670 54197 236511 319190 26754 241113 14282 70377 319176 18034 216440 319181 20014 213988 57261 103963 217351 56637 214150 69038 13135 19247 13819 14969 14968 66753 67819 26554 14056 15170 116891 17454 20338 319169 67075 105787 108079 20846 19079 20848 108097 625328 78303 319188 15270 58205 16818 19082 80286 624153 68292 16430 382522 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.5 Mitochondrial transcription initiation 216151 15278 21780 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME DATABASE ID RELEASE 96%5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 22632 18508 232440 13626 319149 15077 66310 140858 66420 69833 67710 52615 15399 245841 69920 19646 20022 213464 20020 20181 231329 20021 69241 17749 245688 100043714 55982 23808 19401 15267 319168 104625 319167 13654 319186 22658 328572 319178 319183 319182 17268 15400 17344 319190 16475 231051 15412 16658 18514 15407 67278 15401 13018 319176 15423 329559 319181 15410 103889 18771 15436 15434 15394 15429 58184 15183 20185 17979 218772 19411 12914 56406 14056 319169 22289 625328 16476 78303 319188 15270 624153 381022 382522 NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.3 Nuclear import of Rev protein 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 18148 69912 16211 103468 19386 234865 59015 69736 110379 19384 170762 100088 108989 231042 227699 223921 227720 445007 269113 66679 CLASSICAL KIR CHANNELS%REACTOME%R-HSA-1296053.4 Classical Kir channels 16520 16518 16515 211480 PI METABOLISM%REACTOME DATABASE ID RELEASE 96%1483255 PI Metabolism 101476 56209 225326 170749 320207 64436 320634 18710 19211 19249 104015 16331 16332 83493 77980 67073 224020 77116 30955 18708 18709 18706 108083 74769 18707 219024 18718 18704 234729 54384 17772 320981 216724 210376 66569 11840 241274 240752 18705 234129 104709 50767 18720 68616 18719 68365 18717 97287 233315 11842 106869 107650 103199 244882 18711 12169 233552 20975 268783 69769 74302 19341 56305 53332 219135 84095 319934 271457 240753 101490 231999 109135 19062 269180 75669 66443 234515 83435 83436 THE IPAF INFLAMMASOME%REACTOME%R-HSA-844623.2 The IPAF inflammasome 268973 12362 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME%R-HSA-9027283.2 Erythropoietin activates STAT5 20850 13856 13857 384783 16452 17096 20851 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855167 Synthesis of pyrophosphates in the cytosol 56409 217837 75678 102954 27399 271424 227399 71207 327655 NFE2L2 REGULATING ER-STRESS ASSOCIATED GENES%REACTOME DATABASE ID RELEASE 96%9818035 NFE2L2 regulating ER-stress associated genes 12914 328572 18024 11911 17135 SIGNALING BY BMP%REACTOME DATABASE ID RELEASE 96%201451 Signaling by BMP 23893 12165 11705 110542 218441 12154 17129 18121 55994 66105 12166 12167 12168 11482 14314 20481 12156 17125 11481 12622 16323 17128 16322 21814 75788 66313 11480 17130 216080 17131 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 96%174403 Glutathione synthesis and recycling 14629 14598 14854 68044 69065 75475 23887 68252 71522 66054 207182 14630 NEURONAL SYSTEM%REACTOME%R-HSA-112316.9 Neuronal System 18796 18797 18795 17161 12326 14811 18039 14810 11472 20779 320472 23859 19084 14814 68606 52163 14813 26413 26417 18176 15461 13169 17920 108099 18607 14800 11438 110834 11449 110902 54526 640703 11435 11448 11447 11440 108015 108043 11444 110835 231252 20980 22318 20614 20979 20907 84036 18213 140493 16534 240444 75409 58802 16526 16527 216963 223604 386750 238076 15165 63993 15168 225030 16535 72413 16538 16539 16497 74571 14697 16512 98741 66733 380728 240595 72258 16528 14710 16490 14699 16491 66066 226922 14700 16492 216456 15166 192775 16485 170738 14708 16506 14706 16504 99738 110637 16493 14704 14807 16494 14806 16498 14695 13385 16495 14805 242151 52589 16500 53310 16502 14693 13383 268345 14809 13162 16508 64337 56543 14709 382571 241794 16510 211468 217826 20168 106025 16511 14701 14251 56379 211480 332396 16499 67498 238271 330953 435726 14702 14252 14696 19088 19108 11771 104110 14678 14677 14615 14679 14610 432530 55991 210044 14617 104111 406218 14688 224129 11512 11513 11514 11515 18749 14415 14417 16536 110862 242851 19085 13823 19087 16514 238276 60613 12322 16531 12323 16533 140492 108058 12325 192167 54525 233067 20910 57267 228836 331461 226352 18747 242667 56376 171180 100039592 272381 216856 58234 26558 26557 216028 74342 20928 26556 243961 110651 19024 20112 67533 12038 217692 268860 19268 12647 107065 11423 380785 67111 13822 22348 269587 214579 14816 224997 27204 60367 19339 245537 13002 108071 239250 20965 18189 20964 18190 68507 76965 327814 70530 12889 11784 22249 245450 791260 225875 15567 245446 12286 19280 12287 12290 53623 232333 14799 14412 57014 56808 17246 110304 12293 14680 12295 243547 12296 16559 12297 14802 12298 55984 243616 19417 233977 19418 14645 18693 214084 16519 20508 16520 65106 54393 20518 211323 20517 16518 12294 15561 22343 16516 14402 14401 14400 14399 110886 14397 14396 15481 14395 14394 16521 16522 16524 16513 16515 54377 21912 14409 74053 14408 18195 14407 14406 14812 16517 108030 64011 207565 14660 57249 12300 54376 18752 12361 12846 81905 14658 237213 14654 328699 319924 67071 170483 236915 22342 242425 18751 16523 20927 52150 16525 16530 241113 242607 14411 67760 19353 20513 11669 20511 20510 20512 20111 105727 60510 105787 108079 19079 108097 19082 18750 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.2 LXRs regulate gene expression linked to triglyceride lipolysis in adipose 22260 20181 20182 103968 22259 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME%R-HSA-211994.3 Sterols are 12-hydroxylated by CYP8B1 13124 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142712.4 Synthesis of 12-eicosatetraenoic acid derivatives 11686 23801 11684 14775 625249 14776 11687 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 96%73772 RNA Polymerase I Promoter Escape 232440 319149 667501 21429 20019 15077 21340 21339 21341 64424 13871 75316 66420 70333 69833 66136 245841 20017 14885 209357 66467 66671 17749 100043714 17420 12572 13872 23894 14884 15267 319168 319167 319186 319178 319183 319182 319190 106298 319176 21374 319181 20018 20016 319169 12417 625328 78303 319188 15270 624153 382522 RND3 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696264 RND3 GTPase cycle 13836 14252 21927 74194 64652 232906 216197 12709 71435 20355 233877 12389 83669 13510 233489 12874 11855 232339 109620 208994 108686 19249 227937 67586 71228 93840 229658 226525 269608 13206 50875 19877 105782 16709 218581 17063 18708 19655 18709 53382 380664 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME DATABASE ID RELEASE 96%9665245 Resistance of ERBB2 KD mutants to tesevatinib 13866 59079 12539 15519 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 96%9036866 Expression and Processing of Neurotrophins 18552 18550 18553 18049 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME DATABASE ID RELEASE 96%444473 Formyl peptide receptors bind formyl peptides and many other ligands 14289 14294 16952 14293 15199 20210 11820 ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.2 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 108097 19094 26416 108099 19082 241113 19017 108079 29857 19079 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 96%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 70620 667035 22190 107823 68251 20184 240087 11350 70681 70238 27223 107976 210766 19060 104416 22059 59004 225896 14051 22196 93762 22385 11785 15204 230674 19360 14050 14049 17535 14048 319186 27354 12021 319178 319183 319182 81601 50883 319190 319181 11920 12189 319152 93765 193796 26419 78303 319188 15270 382522 LOSS-OF-FUNCTION MUTATIONS IN BCKDHA OR BCKDHB CAUSE MSUD%REACTOME%R-HSA-9865125.1 Loss-of-function mutations in BCKDHA or BCKDHB cause MSUD 12040 13171 12039 LOSS OF FUNCTION OF KMT2D IN KABUKI SYNDROME%REACTOME%R-HSA-9944971.2 Loss of Function of KMT2D in Kabuki Syndrome 66310 140858 213464 23808 381022 STAT5 ACTIVATION%REACTOME%R-HSA-9645135.5 STAT5 Activation 14389 20850 14256 14255 19247 20851 REGULATION OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 96%453276 Regulation of mitotic cell cycle 12234 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19645 19177 21402 26443 26444 12566 19170 66413 26965 56371 667035 27401 22190 59029 67089 70247 30939 18005 20877 12428 229776 12237 67141 107995 12427 56150 21762 22123 20878 19179 19181 19182 217232 23996 56317 12236 19184 59008 18817 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.4 Transport of Mature mRNAs Derived from Intronless Transcripts 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 69912 13684 103468 20492 19386 234865 54451 59015 69736 51786 94230 74320 21681 68188 54188 110379 66899 170762 108989 53319 231042 227699 223921 227720 445007 269113 66679 SIGNALING BY INTERLEUKINS%REACTOME%R-HSA-449147.13 Signaling by Interleukins 12402 20586 107746 12929 26416 12928 56044 18126 26413 26417 20416 19094 102626 26395 20662 17164 215449 216233 12700 22352 16452 15368 12609 17395 16172 17260 11909 268373 15234 20656 56484 16476 16906 22318 20614 20907 16819 11820 14103 257630 56480 171095 56438 68981 53379 98758 16176 12362 15162 12370 16173 22030 67245 69146 18453 16453 16177 54721 16175 20963 13609 434174 20847 17060 50931 50926 16171 66162 18569 12798 18738 50498 12931 11632 20849 209590 18826 17319 18788 16162 16161 246779 15526 16188 16185 12984 12982 16192 16191 13035 12575 12443 19249 16186 19250 19253 104831 19259 16331 19256 16332 16182 24058 16068 18747 320139 56294 19255 12491 73914 20969 73699 11799 110651 20112 16189 16163 19052 16174 19053 51792 93871 19373 19374 53603 16196 57914 21770 66902 26399 20293 26400 26398 26420 26414 26397 23939 16193 667310 26419 21351 100038891 12043 12048 16170 20908 76527 109658 19152 19283 242700 11687 16364 16195 12367 192656 17874 17258 20203 20210 19225 24110 11689 257632 266632 80750 223664 107607 69721 231130 93834 270151 16409 11596 22329 67454 240518 71966 108960 59025 16411 100040260 16414 101568 235584 67603 319520 72349 14281 224105 18034 15894 19247 15170 17390 20846 20848 16818 16451 17161 319149 22612 11651 22324 15077 18710 16153 71481 211550 21417 56468 26410 14360 17869 15251 17096 12504 22160 12772 12774 12768 18708 18709 18706 74769 18707 12519 18386 12524 12702 14462 16198 16199 16477 14293 16880 21454 12346 21682 20303 20304 20292 73086 20302 20297 100039973 20299 16184 16183 330122 16412 22059 14825 16803 19258 20851 20850 18712 14784 16952 15945 19248 20909 18986 12340 21857 12306 17829 21803 17698 20663 12330 331461 15519 17127 19204 667618 17392 16190 69677 100042555 13712 16156 83995 17984 18412 107527 16165 16164 14086 26406 19229 56708 19885 77125 50905 11840 18413 329244 15481 17210 237310 20955 213208 237313 54450 60505 338374 93672 58181 60504 116849 215274 69581 21762 16169 22123 16168 12675 140806 17082 19179 18414 19181 53314 19182 54473 23996 218624 19184 14873 215257 18033 234836 26440 13019 19166 230828 18035 57890 19167 12804 18036 12981 12803 26441 12978 54448 384783 26442 69077 66997 23997 12234 14389 56436 16367 17463 57296 20422 26445 26446 19172 19173 19175 56458 19697 19177 20674 21402 16150 26443 14173 26444 16151 19170 66413 26965 16179 667035 22190 18390 59029 26409 16194 67089 103583 70247 12986 19883 16181 16776 16878 14128 21937 21938 16178 14268 16160 16159 16155 16154 21926 12985 22027 12053 15978 12843 20911 20852 19188 66513 93765 66589 22034 66724 74145 68652 12631 20111 22631 16197 18976 22339 12977 12703 DEGRADATION OF DVL%REACTOME DATABASE ID RELEASE 96%4641258 Degradation of DVL 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70247 26554 13542 21762 22123 19179 13544 19181 13543 19182 23996 19184 26440 19166 19167 26441 240756 26442 94253 69077 66997 23997 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%177243 Interactions of Rev with host cellular proteins 18141 107939 69482 71805 54563 19069 70699 72787 103573 18226 218210 18148 69912 16211 103468 19386 234865 59015 69736 110379 19384 170762 100088 108989 231042 19385 227699 223921 227720 445007 269113 66679 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME%R-HSA-3134973.3 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 12914 328572 12387 54131 RHO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9012999 RHO GTPase cycle 56324 20779 56374 15239 381293 20867 12389 83669 20844 18844 108670 12874 59009 232339 107746 14786 223881 208994 108686 66922 227937 20257 67586 71228 68187 93840 11671 327826 22325 77480 57257 246710 50875 29875 20662 19877 15381 83946 106504 52666 109331 16800 11465 263803 12848 52428 19230 13605 17920 270163 22352 20166 19878 236920 76626 26403 13830 56381 16480 19655 68743 53382 20874 15516 213498 70804 100043806 12704 269061 243362 26891 110596 56320 207212 109711 19285 12539 71704 20462 234094 69288 11464 242202 50768 56349 54216 16801 11852 404710 13367 75547 20868 268301 320795 109333 72754 208846 69632 213649 24001 224014 230098 53972 15369 30938 66508 442801 226970 235611 54126 101497 269608 14163 26382 268739 14674 73341 11853 16906 54411 105827 195727 210293 50884 71709 22042 83767 170758 329165 109934 106952 71893 26934 110279 330177 75409 105855 242687 216963 386750 17969 20947 212285 237038 70497 320634 27061 11308 20619 224480 11856 13058 241275 13171 13057 108100 76117 218952 26431 17970 101314 17972 66898 71302 71544 12261 14251 14252 67784 73178 78514 17827 68653 26554 226525 245880 22376 215280 68524 67299 330319 76884 66894 223870 19249 217866 105782 14269 22379 80837 214459 14467 66871 226751 76088 218756 18221 19418 21844 208869 107971 236915 16449 21873 13511 13510 109620 19299 58220 227377 224105 259302 223666 14270 117600 19353 20514 16818 18806 22324 269523 18710 72565 74201 12988 13206 12638 18708 18709 18479 18706 98386 101565 18481 19354 14609 12466 12468 22143 12461 11848 102098 56513 68146 22319 11855 277360 192662 263406 11857 14570 68813 11461 19349 18805 624814 70584 68428 56418 56384 70361 233103 229658 544963 622434 66251 68202 16412 545156 16443 13726 23943 75739 140579 628438 71782 17207 94176 330662 94190 16709 52331 218581 84004 21917 56491 109904 238130 230972 20430 223921 56419 380664 104445 56389 13836 59079 108037 69922 223435 330914 232906 56212 71435 228359 59069 12345 11352 53332 17974 67300 17063 17925 20740 214230 17973 20742 20663 241656 15519 21927 74194 64652 216197 12709 20355 233877 22284 19229 51796 53817 69581 238505 22637 213522 329366 56784 20401 233071 75974 12549 58996 66146 214345 208263 192652 239027 70350 74159 71409 74018 106326 244867 70598 192192 319899 260409 57778 386649 226823 21763 216445 69710 211499 244895 216831 268970 70719 328232 244418 101240 232201 73167 78816 228482 72729 104252 231532 68917 27360 69668 14218 71972 225358 214137 75415 171207 74734 71703 77038 228543 58804 56699 214804 269682 77006 223254 102075 66087 11736 23912 207425 19765 54004 73910 83397 269401 434204 207495 76763 94221 11858 213783 100038946 71085 545481 23853 210998 233489 219140 226652 14787 11854 232237 27984 75089 76577 20403 76983 106628 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 96%5657560 Hereditary fructose intolerance 230163 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206307 MPS IIIA - Sanfilippo syndrome A 27029 REGULATION OF CDH1 POSTTRANSLATIONAL PROCESSING AND TRAFFICKING TO PLASMA MEMBRANE%REACTOME%R-HSA-9768727.1 Regulation of CDH1 posttranslational processing and trafficking to plasma membrane 66357 66624 19089 13200 12387 330914 12550 11735 66286 20014 18550 103963 18553 12330 69038 13135 76687 69019 13001 18554 13000 100039026 18717 56529 57377 217734 16480 99011 14376 16430 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.3 Nucleotide-like (purinergic) receptors 67168 574402 18441 78134 18442 70839 57385 78826 74191 233571 11539 11541 235036 11540 140795 11542 NPAS4 REGULATES EXPRESSION OF TARGET GENES%REACTOME%R-HSA-9768919.3 NPAS4 regulates expression of target genes 12914 52897 54526 19713 16334 17246 59027 243621 225872 12064 103573 20620 14579 14281 12569 12568 11863 11865 26413 26417 11864 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.4 Defective ABCB4 causes PFIC3, ICP3 and GBD1 18670 DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME%R-HSA-5682294.4 Defective ABCA12 causes ARCI4B 74591 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.3 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 17155 17156 230815 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.4 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 97212 11363 231086 11364 67460 13177 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 96%8857538 PTK6 promotes HIF1A stabilization 93695 20459 15200 13649 15251 66725 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693616 Presynaptic phase of homologous DNA pairing and strand exchange 12021 81601 327762 20422 19361 114714 22427 19718 69263 15574 11920 12189 12190 235610 231724 237911 19355 57434 225182 26909 235559 12144 68275 106344 72151 68240 19891 19367 19356 12649 19360 17535 21975 19363 19364 27354 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME DATABASE ID RELEASE 96%8876198 RAB GEFs exchange GTP for GDP on RABs 270160 22241 70785 235633 242406 192232 56382 60409 211922 225870 329260 216131 69440 19328 12663 217449 74018 11651 12662 11652 11891 19349 77980 19339 17274 80718 216363 66691 67091 66226 19324 19325 68328 75964 270096 217835 14569 68365 66975 14567 72433 227801 102442 66682 76954 106572 19347 229541 245828 72121 67790 72825 320714 226089 216344 59005 67844 270192 77407 74760 19345 319934 78232 245886 271457 320560 19344 319642 329727 22627 320435 19346 27096 226407 235442 105841 19330 56715 76308 74030 23797 76510 329877 209773 192236 GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.7 GABA receptor activation 242425 14697 14710 14699 66066 14700 14708 14706 14704 14695 14693 64337 14709 14701 14702 14696 14680 16519 16520 104110 54393 14678 16518 14677 16516 14402 14401 14679 14400 432530 14399 210044 110886 104111 14397 14396 14395 14394 14688 16521 16522 16524 16513 16515 14409 224129 14408 11512 11513 14407 11514 14406 16517 11515 57249 328699 236915 242851 DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.4 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) 114479 MAP KINASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%450294 MAP kinase activation 12234 21402 73086 16150 16151 192656 16179 26965 667035 26416 22190 17258 26410 26409 26413 103583 257632 26417 107607 19094 102626 231130 73699 26395 110651 108960 20112 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 21770 26399 26400 26398 26420 13712 26414 26397 17260 66513 93765 66589 23939 22034 66724 68652 20111 11909 26419 12675 16476 18033 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6785470 tRNA processing in the mitochondrion 52575 68626 66132 15108 70047 ANTIGEN PROCESSING: UB, ATP-INDEPENDENT PROTEASOMAL DEGRADATION%REACTOME%R-HSA-9912633.1 Antigen processing: Ub, ATP-independent proteasomal degradation 26445 16912 26446 19171 19172 19173 19175 19177 26443 26444 19170 16913 19186 26440 19188 19166 19167 26441 26442 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME DATABASE ID RELEASE 96%186763 Downstream signal transduction 74769 17973 20779 20851 12927 20850 107746 14786 20852 12929 12928 19247 18595 18176 20846 20662 218397 20848 15461 17974 18803 18708 18709 18591 18706 18596 SIGNALLING TO RAS%REACTOME DATABASE ID RELEASE 96%167044 Signalling to RAS 18211 19094 20418 102626 19730 26415 18176 20662 15461 17164 26416 56044 64143 18049 216148 29857 20416 ADRENOCEPTORS%REACTOME%R-HSA-390696.5 Adrenoceptors 11554 11555 11556 11551 11552 11553 11550 11548 11549 NFE2L2 REGULATING INFLAMMATION ASSOCIATED GENES%REACTOME%R-HSA-9818026.1 NFE2L2 regulating inflammation associated genes 12914 328572 18024 20293 17135 EPIGENETIC REGULATION BY WDR5-CONTAINING HISTONE MODIFYING COMPLEXES%REACTOME%R-HSA-9917777.1 Epigenetic regulation by WDR5-containing histone modifying complexes 15161 232440 20602 319149 23989 19645 217031 226976 208146 66853 59024 11450 18631 327987 76719 15077 57435 68801 66310 75812 21835 140858 14311 69556 69612 233904 68975 101206 14081 13486 234959 217588 213464 54194 108946 67933 665775 214162 75565 11350 228714 28077 70208 67773 239510 12491 21664 77305 75410 171285 23808 11520 56771 19014 328572 21372 231051 74322 17977 19017 17978 81004 69790 56310 208043 26896 15183 20185 93759 12914 56406 14534 22289 27273 170826 12568 381022 14732 20249 12606 20181 55982 15267 319168 319167 264064 319186 319178 319183 319182 228829 67279 108155 319190 16475 57875 67278 17283 23945 319176 101739 16890 16956 319181 14245 103968 17979 216154 67800 51813 11770 26424 319169 18519 69792 67512 625328 67381 78303 319188 15270 624153 382522 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol 20181 20186 13123 104086 17977 13122 77337 208665 101502 83702 13124 17978 105349 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME DATABASE ID RELEASE 96%9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 13856 13857 18803 234779 384783 16452 17096 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME DATABASE ID RELEASE 96%5675482 Regulation of necroptotic cell death 14103 56532 14252 74568 12539 22030 108155 56424 21933 67245 11796 11798 53378 667035 71609 22190 14082 15519 14102 14251 18571 22195 22035 50873 16396 12370 19766 11797 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME DATABASE ID RELEASE 96%166016 Toll Like Receptor 4 (TLR4) Cascade 103967 66105 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 20201 20202 11909 26419 13430 12675 16476 18033 18035 18036 24088 11820 21897 12234 56480 54131 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 21899 69721 231130 93834 270151 16409 11596 22059 67454 240518 71966 108960 59025 100040260 16414 101568 235584 67603 319520 72349 14281 12370 19766 17079 11797 16803 56532 329547 17084 22030 19258 12475 22031 67245 56489 234779 225471 11796 106759 21353 18034 71648 54123 12229 434174 100041766 14082 66513 93765 66589 19247 22034 66724 68652 20111 13429 216080 12703 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.4 Variant SLC6A14 may confer susceptibility towards obesity 56774 MINUS-STRAND DNA SYNTHESIS%REACTOME%R-HSA-164516.4 Minus-strand DNA synthesis 268373 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173736 Alternative complement activation 14962 12266 11537 16904 DEFECTIVE TCN2 CAUSES TCN2 DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3359454 Defective TCN2 causes TCN2 deficiency 21452 NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5675221 Negative regulation of MAPK pathway 16706 225849 26931 21770 26932 109880 667035 22190 26413 26417 29857 320139 17169 19060 54401 70686 73699 26395 26396 18176 75590 15461 110157 235584 231474 23980 67603 19052 18218 319520 63953 19053 13537 51792 19252 11836 240672 72399 226849 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.3 MyD88 deficiency (TLR5) 17874 53791 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%189451 Heme biosynthesis 19044 70383 26357 15288 22276 12892 17025 11657 11655 11656 14151 226139 22275 DENGUE VIRUS ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9920588 Dengue virus activates modulates innate and adaptive immune responses 317677 12759 23845 17195 69940 12259 11806 56489 236732 72512 20847 214763 13205 76246 15519 214498 66317 625018 69116 235497 22083 71586 228607 54624 217069 22370 15516 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 96%8964038 LDL clearance 100017 232910 11773 100102 16835 67963 238055 54135 11771 16889 11772 71770 67300 13909 12757 320024 223920 18145 20652 ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME%R-HSA-4608870.3 Asymmetric localization of PCP proteins 56436 17463 57296 20422 26445 26446 19172 19173 56513 19175 19177 57265 26443 26444 19170 66413 667035 22190 59029 67089 93840 70247 105782 66313 106042 14367 14365 14362 14366 22418 14370 14369 21762 22123 19179 19181 13543 19182 23996 19184 75788 26440 19166 19167 26441 26442 69077 66997 23997 MTF1 ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%5660489 MTF1 activates gene expression 13007 104069 17764 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME%R-HSA-4655427.5 SUMOylation of DNA methylation proteins 19763 13436 13435 13433 54383 13619 30951 241915 12416 22196 12418 19821 12151 22658 COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811436.2 COPI-independent Golgi-to-ER retrograde traffic 28169 108148 56444 67665 56455 22428 12121 13191 76895 12344 18476 59288 69654 18475 53357 18472 234663 12343 12345 235661 12340 18783 68097 14423 54130 270192 53598 13427 19346 13426 226407 13424 19330 NERVOUS SYSTEM DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9675108 Nervous system development 20437 20665 18992 58194 20586 20779 20404 17295 18844 14786 223881 26413 26417 20416 327826 22325 20418 26395 26396 57257 18176 20662 19877 15461 16416 11465 21894 19878 15516 213498 110596 17395 11852 65254 319713 14587 14586 20358 19122 69632 19197 12517 69585 210801 14588 53972 215798 114873 20346 19262 19264 216439 235611 20351 54126 12292 15357 244058 208643 110789 17528 22288 26757 19056 19153 83433 18845 22253 11853 17196 20349 140571 18858 22177 18846 231148 22240 57764 623279 13497 13508 76829 54712 12569 20361 12568 114255 18188 12933 110351 214968 11876 13449 13448 68799 226251 216963 56438 77579 71960 20354 20130 16885 16886 13121 20788 12830 13385 12829 12828 12827 53310 12826 13383 19164 19165 12841 100042305 208117 12840 59287 100039623 245026 12839 12835 12834 12833 67784 76709 53378 73178 11771 11772 71770 56443 22359 19699 13131 68089 67771 11867 56378 66713 18738 232910 74117 11773 218397 18749 13004 17909 18747 15529 110651 20112 14573 57294 14585 76707 14733 23939 18007 14812 14388 21844 18803 13835 76499 67071 11487 11603 227377 21676 224105 13654 19876 259302 223666 20563 14270 117600 19353 56637 19247 13848 13846 13845 270190 13842 13840 17390 13841 13839 13838 13837 13637 13636 13643 13642 13641 13640 13639 13638 18750 17136 14810 17936 17937 22612 18710 17886 97064 14360 13001 67268 13000 100039026 13649 22601 17096 18708 18709 18479 18706 12288 74769 18707 18481 107449 68092 107448 433702 67923 11848 14159 73086 11461 70584 19713 16412 545156 16443 330662 243743 58226 12291 13836 239556 67938 17904 223435 232906 17880 27207 67097 670832 633683 13866 20044 27050 667279 20085 668144 12289 20084 67186 382492 20055 75617 27370 18222 65019 16410 16571 20356 629957 14083 21367 20102 53870 268721 24046 20103 11352 13844 668668 14853 16728 667739 17974 12661 16825 16392 18187 67300 20315 13429 672214 170822 13193 12757 54003 19684 66481 71745 12934 225058 17925 16536 100038875 18208 17698 100038991 225363 110862 68028 14026 104099 100043000 17690 20739 67891 18458 20740 100043295 13138 235281 622534 14852 56613 238217 214230 74947 17973 20266 16785 16870 20265 666669 16871 12805 100040021 12767 11733 67025 268902 11735 100043391 326622 14432 668182 13176 640524 241053 18186 20742 16876 20741 432502 19087 319504 238276 20743 19989 20663 26394 76808 67252 20271 19899 12331 399548 100043184 241656 20272 19921 71436 20274 19934 18643 20273 100043755 18645 103967 22323 11658 16872 110876 67031 53321 319195 20564 20269 100043209 20562 72821 68193 15399 110880 621100 22350 19941 17967 665189 269116 666899 71653 100042670 80297 15519 20264 100039316 213119 11350 22121 56705 58234 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 20450 67941 20452 12295 12296 12297 12298 74325 15481 192160 13430 21762 22123 60365 19179 19181 19182 23996 19184 68134 26440 19166 19167 26441 192170 384783 26442 19826 69077 66997 23997 66441 14389 56436 17149 17463 57296 20422 26445 26446 18991 19172 19173 19175 19177 26443 26444 19170 22063 109700 66413 22065 16398 22067 667035 22066 22190 22068 59029 67089 70247 26946 16777 226519 16399 16772 16402 16773 14783 18761 12631 20111 18717 15182 20439 CHROMOSOME MAINTENANCE%REACTOME%R-HSA-73886.4 Chromosome Maintenance 232440 22589 217653 20892 233532 100038822 70645 66311 66578 12566 16881 13163 21752 19646 70454 71876 245688 320394 102920 28113 101185 26886 72155 12428 57321 12617 83815 12615 319152 66570 56505 21749 497652 21750 67733 76464 12427 60411 66336 69928 52504 208084 245474 14156 72171 214987 214901 20174 68964 72107 108689 69535 66181 216853 18148 68147 66420 69833 67710 52530 245841 69920 20022 20020 231329 18969 20021 18968 69241 17749 100043714 19075 19076 93762 15267 319168 319167 69745 319186 319178 319183 319182 327762 269400 319190 22427 19687 19718 319176 69263 319181 18538 105522 12144 68275 106344 72151 18971 67857 68240 18972 19891 319169 52036 67967 625328 78303 319188 15270 624153 382522 PARASITIC INFECTION PATHWAYS%REACTOME DATABASE ID RELEASE 96%9824443 Parasitic Infection Pathways 17913 13479 58861 246256 17973 14131 17909 66824 330319 216799 76884 12495 19087 19084 22612 22324 217344 20620 93671 16153 17886 26416 12928 26413 229709 26417 14360 16438 16439 18747 22325 11350 16440 12502 57257 17096 11465 22166 15516 15368 18550 16193 640703 26419 16476 18033 18803 50884 83767 329165 71893 105855 11491 242687 19697 237038 11308 14697 241275 13057 108100 11461 14710 14699 66066 14700 101314 14708 14706 12266 14704 14695 14693 140579 64337 14709 16176 330662 12362 14701 15162 56338 140580 20430 14702 16173 14696 19088 234779 69146 17918 19108 12499 18034 12267 76709 73178 19353 104110 22418 20963 16175 14678 14677 12229 56443 14687 19200 14679 432530 210044 14369 104111 80987 68089 14688 67771 11867 54483 56378 18438 66713 74117 13542 70086 224129 245880 11512 11513 11514 11515 14191 18749 13544 14083 13543 22376 215280 14598 18439 319446 68524 67955 13035 11541 23959 17925 23887 17882 14129 242851 19085 IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.3 IRF3-mediated induction of type I IFN 72935 72512 56480 446099 268857 54131 22596 207521 14375 17535 19090 22040 AGGREGATED Β-AMYLOID INDUCES FXII AUTOCATALYSIS%REACTOME%R-HSA-9936900.1 Aggregated β-amyloid induces FXII autocatalysis 58992 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.3 Orexin and neuropeptides FF and QRFP bind to their respective receptors 15171 237362 387285 230777 229214 227717 104443 54615 NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-HSA-2995410.7 Nuclear Envelope (NE) Reassembly 12534 53857 22152 227613 22153 238799 22142 22146 116733 67951 16211 73710 13726 22145 66371 71782 22196 545486 68953 238463 75608 19052 51792 19384 170762 100088 227699 208092 66700 445007 269113 380664 23825 107939 69482 71805 98386 226747 70699 72787 18226 105513 69912 103468 22367 71955 64383 224640 319965 234865 50850 12442 100042651 71978 59015 69736 22147 110379 16906 22151 22143 MRNA EDITING%REACTOME%R-HSA-75072.5 mRNA Editing 11810 80287 11811 56417 69865 71281 110532 DEFECTIVE ABCA1 CAUSES TGD%REACTOME%R-HSA-5682113.5 Defective ABCA1 causes TGD 11303 11806 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.3 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 17685 68275 17686 17350 18971 68240 18972 19891 67967 16881 69745 26909 18538 18861 SENSORY PERCEPTION%REACTOME%R-HSA-9709957.5 Sensory Perception 77337 83702 19230 11806 238055 640703 231252 22318 20614 20907 258299 258381 258992 258486 258650 258487 257884 18367 258991 258736 258097 258794 52250 14699 258857 259111 258836 258821 56858 258542 258405 258935 258420 258321 259036 259034 259119 14695 56307 18324 258697 258432 258675 258673 64337 258677 257905 258334 258025 667918 258832 77974 258469 258882 258601 258853 259112 258657 18366 235033 18328 258470 258600 258338 258455 259053 14919 258027 68453 56015 20148 67442 259041 258573 259049 98711 258563 259013 117004 19682 258846 258105 16956 20897 329460 216454 258854 258930 17252 258281 73582 241452 257962 105349 258387 18314 259063 258896 404315 258453 11807 257883 11808 104111 258586 258869 258587 14688 668825 258363 110606 80706 258362 257909 14272 258575 258358 258658 258616 16835 258941 11813 258944 11814 258618 18369 258216 237178 258866 258580 258582 15485 27400 241431 16971 73750 228228 140476 258160 16470 258267 17910 258350 23999 258544 22295 258772 17921 258640 667663 258608 381375 259015 193385 404329 242851 20776 259110 11994 546747 17913 13823 258636 227357 259109 192140 258715 13409 259014 238021 258395 628870 259051 332309 258680 18419 259045 97031 258155 80979 259100 17524 258154 56506 258805 102502 258147 224796 257916 72088 258572 67972 98845 258990 328789 18313 56226 258749 60613 258340 16531 433899 18331 16533 13860 259097 140492 329421 258036 504186 227753 258355 404318 259047 19892 258980 259004 258407 259017 75624 259019 15529 170639 23888 258371 20971 259113 258656 24013 258562 436002 20969 258424 16440 258752 18365 258939 258961 258268 258305 100038859 100043474 259074 258507 71951 258427 20970 259122 257917 404346 258819 258672 14735 259075 259040 259058 258746 57251 258614 19771 258700 258694 258478 258443 258178 546729 258222 258775 15530 14680 258352 258248 258831 258196 258458 18315 258776 259054 404317 103978 63857 55938 258720 16518 258985 258690 258373 404222 18317 258717 14733 258937 668035 259071 258292 258531 258756 258238 258710 259106 258322 258946 79235 258975 258763 170752 14734 258325 258536 258925 258924 245532 258706 404331 258302 258804 258713 239766 258270 258704 12361 259147 18343 18310 258310 258303 259115 259012 258357 258347 259035 258296 258179 259066 258206 259095 259092 65107 244187 67861 258098 259089 107477 258163 14913 224055 258914 258319 245650 258759 258609 257898 14685 258287 20215 258506 12788 258922 214111 258316 212541 258354 240669 18346 239393 259002 11304 258814 259067 258620 11603 258207 70061 18341 18357 18330 218066 258016 257972 29849 69060 258729 545140 109791 258769 257985 102294 19662 258075 258515 258439 19660 258271 19661 258408 13591 243923 19659 258153 18312 258481 258318 258275 404319 19674 20278 258151 258933 258039 18322 258908 258702 258703 258659 20276 21906 20277 243634 225600 233649 18750 12789 18587 18588 18796 18108 665270 17886 18107 14539 387513 387353 387515 353148 353165 387348 110326 83770 12057 22139 268934 83771 574417 387347 57253 57254 387355 387342 387349 387616 240899 83762 26875 12343 12345 12217 12289 216227 29866 20977 12340 16825 19684 17698 20740 20266 16870 20742 11816 399548 20274 110876 20269 72821 22350 14816 19339 13002 20964 56808 12296 68667 56843 18761 14725 TRANSCRIPTIONAL REGULATION OF BROWN AND BEIGE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-9843743.1 Transcriptional regulation of brown and beige adipocyte differentiation 216848 12865 17977 19017 107932 70673 22227 12683 12686 94187 19646 234366 116871 12162 51810 116870 13592 20181 19013 245688 17125 19016 17128 23942 17192 433759 170826 15182 229542 NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%383280 Nuclear Receptor transcription pathway 21833 20602 353187 13865 19885 13983 22026 20185 192292 225998 218772 217166 19411 23957 22260 21907 20181 22337 13864 19013 13982 20183 22025 20182 19883 11835 18227 26381 26380 26379 15370 19016 75692 26423 19401 19015 21834 18667 19014 30942 15378 ACTIVATION OF IRF3, IRF7 MEDIATED BY TBK1, IKKΕ (IKBKE)%REACTOME DATABASE ID RELEASE 96%936964 Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) 17087 56480 54131 12475 22031 56489 225471 106759 21353 71648 54123 667035 21898 22190 19247 VARIANT SLC6A20 AFFECTING AMINO ACID TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME DATABASE ID RELEASE 96%5660686 Variant SLC6A20 affecting amino acid transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) 102680 FATTY ACYL-COA BIOSYNTHESIS%REACTOME%R-HSA-75105.12 Fatty acyl-CoA biosynthesis 14104 19063 257633 433256 83603 74522 54397 50790 15487 328845 74205 20249 57874 68801 14979 30963 170439 104112 106529 54325 66775 12686 94180 14081 107476 216739 74559 234309 243078 70757 56348 99035 26568 54326 26458 IMPAIRED BRCA2 BINDING TO PALB2%REACTOME%R-HSA-9709603.2 Impaired BRCA2 binding to PALB2 12021 81601 327762 233826 19361 114714 22427 19362 11920 12189 12190 237911 57434 19360 225182 26909 17535 21975 19363 19364 12144 27354 ACYL CHAIN REMODELLING OF PI%REACTOME DATABASE ID RELEASE 96%1482922 Acyl chain remodelling of PI 77582 18778 18783 329502 66857 271844 18779 26971 232889 225845 26970 26565 18784 18782 78390 66350 CELLULAR RESPONSE TO HYPOXIA%REACTOME DATABASE ID RELEASE 96%1234174 Cellular response to hypoxia 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 13856 230099 66413 66105 667035 22190 59029 67089 70247 15251 53417 328572 17684 16475 100041766 11863 13819 12914 101543 112407 112406 29806 319594 67923 21762 22123 19179 19181 19182 23996 19184 26440 19166 216080 19167 22339 22346 71745 26441 26442 69077 66997 23997 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5676590 NIK-->noncanonical NF-kB signaling 12234 56436 53859 17463 57296 20422 26445 26446 19172 19173 19175 19698 19177 21402 18034 26443 26444 19170 66413 26965 667035 22190 59029 67089 103583 70247 22200 21762 22123 12675 19179 22192 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 CASP8 ACTIVITY IS INHIBITED%REACTOME DATABASE ID RELEASE 96%5218900 CASP8 activity is inhibited 14103 22030 71609 14082 22035 21933 12370 19766 14102 RHOA GTPASE CYCLE%REACTOME%R-HSA-8980692.2 RHOA GTPase cycle 12389 22324 22325 57257 29875 19877 52666 16800 263803 22379 52428 13605 270163 20166 19878 236920 13830 16480 18708 68743 18709 20874 213498 70804 12704 243362 110596 207212 19285 71704 234094 98386 11464 50768 56349 54216 16801 404710 13367 19418 75547 20868 268301 320795 109333 72754 208846 69632 213649 53972 15369 442801 226970 54126 269608 268739 21844 54411 22042 213522 109934 106952 26934 110279 12549 11848 58996 102098 66146 239027 74159 21873 212285 27061 244867 22319 20619 11855 277360 11856 192662 263406 11857 21763 216445 69710 18805 19299 211499 216831 56418 268970 70719 71302 70361 71544 229658 73167 78816 228482 545156 12261 231532 69668 17207 214137 94176 171207 94190 16709 14251 52331 218581 84004 21917 56491 109904 77006 223254 223921 102075 56419 66087 56389 14252 59079 73910 223666 223435 117600 330914 232906 71435 228359 100038946 71085 545481 23853 226652 14787 76577 78514 76983 17925 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665686 Signaling by ERBB2 TMD JMD mutants 13866 59079 12539 13649 18183 83961 100042150 12223 18176 20662 13874 15461 15200 211323 18803 13645 20416 15519 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME%R-HSA-9022699.2 MECP2 regulates neuronal receptors and channels 19258 14811 26913 14812 17295 20466 22065 14229 433759 18387 19246 18390 15182 14800 20527 ACTIVATION OF PKB%REACTOME%R-HSA-165158.6 Activation of PKB 228775 75778 11652 18607 PDGFR MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 96%9674428 PDGFR mutants bind TKIs 18595 SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855183 Synthesis of IP2, IP, and Ins in the cytosol 56727 114663 55980 71780 212111 16329 320634 54384 104015 210376 269180 16330 234515 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 96%381426 Regulation of IGF Activity by IGFBP 94111 20750 13406 30060 15464 11704 19089 71421 217847 18491 77583 105348 80752 23850 16852 18220 11816 15160 66853 626834 20856 381677 66848 338366 83554 11576 12558 66557 98170 17182 14314 16425 232146 12155 76453 74761 15529 16002 16000 100037258 14161 71853 29817 99571 22393 12159 216197 11806 238055 14061 83995 16193 385643 14734 19123 12870 22041 11820 14456 11487 64654 11905 13010 17304 18619 56453 12266 625018 14943 16777 21923 16779 226519 14268 16709 14118 382014 22027 12321 100102 17283 20255 18453 16009 16006 66113 104009 11657 20703 11625 11807 14067 17390 21857 18815 16008 16005 269181 66940 208659 13003 13602 16007 16012 75396 16011 16010 13035 246228 12977 13801 11804 12653 11698 20254 56047 268977 19672 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME%R-HSA-6781823.4 Formation of TC-NER Pre-Incision Complex 56438 667035 13871 22190 66420 67439 69833 67710 245841 69920 20022 14885 66983 209357 71101 66467 71991 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 23894 14884 11834 12848 100043806 26891 319955 26754 56031 26893 21399 26894 28000 108679 252870 22590 26572 26895 57905 99375 72584 13194 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME%R-HSA-68616.6 Assembly of the ORC complex at the origin of replication 319178 319183 319182 232440 319190 319149 16646 16650 319176 319181 15077 50793 18392 18393 26428 26429 56452 16211 319169 625328 15267 78303 319188 319168 15270 319167 624153 319186 382522 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 96%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 18969 18968 19052 19053 51792 19075 19076 211586 13555 73699 19645 21781 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME%R-HSA-201681.3 TCF dependent signaling in response to WNT 21415 20682 232440 12387 319149 20586 84092 16842 68031 11651 12389 11652 21951 74493 15077 66310 140858 12005 21752 213464 20668 234130 73016 13001 84035 13000 228770 100039026 103236 17869 56811 20680 24117 75410 14296 73699 74499 207742 14160 20319 20377 23808 20187 20675 20677 212398 19052 100683 107515 19053 66313 192199 51792 77578 68911 12006 67772 67087 80288 16974 13380 16973 329252 73739 226849 72135 225849 328572 20679 68339 26931 239405 21770 407821 26932 21414 21416 103573 319152 56505 72780 214498 12914 235497 21762 22123 19179 19181 19182 23996 19184 26440 19166 13016 19167 26441 240756 26442 11789 94253 69077 66997 23997 27373 12234 93687 56436 17463 57296 20422 26445 26446 19172 19173 19175 72345 19177 20674 56438 57265 26443 26444 19170 66413 667035 22190 216795 59029 67089 70247 21885 21886 21888 22417 15267 319168 319167 319186 319178 319183 319182 81601 319190 20671 14367 17283 14362 12399 22415 319176 11798 14366 22416 319181 22418 14370 56637 14368 22423 20890 22408 21887 26554 18719 13542 319169 22631 13544 13543 625328 78303 319188 15270 433759 624153 382522 SIGNALING BY CSF1 (M-CSF) IN MYELOID CELLS%REACTOME%R-HSA-9680350.3 Signaling by CSF1 (M-CSF) in myeloid cells 14389 74769 18707 210710 12402 234779 20779 22612 667035 22190 19247 16331 14360 16332 20416 17096 20846 20662 20848 17444 16653 15162 107829 12977 12978 18708 76527 18706 RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 96%392517 Rap1 signalling 18747 109905 380711 20469 19419 54401 22631 18749 110157 215449 56508 223864 110351 19395 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.2 Synthesis of diphthamide-EEF2 67728 116905 67228 105638 99349 13629 66632 69740 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.2 Regulation of cortical dendrite branching 19876 17974 268902 20562 VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 96%4420097 VEGFA-VEGFR2 Pathway 18762 17973 12388 11848 12387 105855 242687 12562 76884 17969 11651 12389 11652 11308 22324 13058 19303 13057 26416 108100 12928 18751 17970 216148 101314 229709 17972 14360 16438 29857 16439 15519 18747 22325 19094 15507 102626 16440 26415 18753 57257 140579 18176 19877 16416 15461 330662 17164 78757 228775 20698 19878 140580 224105 16480 18708 75778 18709 20430 18479 18706 18607 12385 74769 18127 27371 230126 18481 56717 19353 12927 19229 227743 640703 109270 245880 16410 218397 18749 14083 17974 18803 16542 50884 56716 18750 83767 26362 23797 329165 FORMATION OF THE NON-CANONICAL BAF (NCBAF) COMPLEX%REACTOME%R-HSA-9933947.1 Formation of the non-canonical BAF (ncBAF) complex 67155 20586 210982 105246 20588 243842 56456 269397 68094 83796 66993 83797 268996 12055 12054 11461 77045 MPS I - HURLER SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953038.1 MPS I - Hurler syndrome (CS DS degradation) 15932 REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-9707587.4 Regulation of HMOX1 expression and activity 14950 15368 12013 18024 17135 FRUCTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 96%70350 Fructose catabolism 230163 235582 16548 225913 11668 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 96%2132295 MHC class II antigen presentation 74947 16570 20743 20404 103967 12330 73470 16563 16568 234663 19025 68097 73804 53598 13038 56444 13039 67665 22428 56455 13191 12344 59288 16594 229841 668303 16579 232943 13036 13034 19348 229445 56464 71819 226977 16593 16551 110033 280408 16149 209737 11840 74764 15002 15001 64291 16768 15000 14998 235661 13430 110379 13427 13426 13424 228421 26934 66397 69608 218811 99683 19349 77371 20334 16572 16573 65972 13040 19141 11768 11769 13030 108012 11764 11765 11767 252903 69654 11771 11772 71770 13033 14969 14968 69162 12343 12345 232910 11773 16569 12340 13032 16571 54130 67300 13429 12757 REPRESSION OF WNT TARGET GENES%REACTOME%R-HSA-4641265.5 Repression of WNT target genes 21885 21887 21415 14797 13017 433759 21414 13016 21416 21886 21888 16842 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME%R-HSA-2046104.3 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism 11666 15488 113868 68801 54326 170789 56473 76267 54325 20280 12686 14081 HOST INTERACTIONS OF HIV FACTORS%REACTOME%R-HSA-162909.3 Host Interactions of HIV factors 14360 16211 19386 12504 19384 100088 19385 445007 12487 103573 107951 11840 69912 108664 103468 268373 67923 234865 21762 22123 12455 59015 19179 69736 19181 19182 23996 19184 110379 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 18148 667035 22190 59029 67089 70247 94176 15007 15162 170762 12010 12526 224105 108989 11768 140580 231042 11769 227699 108012 223921 11764 227720 107975 269113 11765 66679 11767 18141 252903 23825 107939 69482 71805 11739 433923 11740 54563 16646 19069 15361 70699 101739 72787 18226 218210 19353 11771 11772 71770 232910 11773 75717 16818 BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.2 Biosynthesis of E-series 18(S)-resolvins 16993 15446 11687 11689 RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME DATABASE ID RELEASE 96%6802953 RAS signaling downstream of NF1 loss-of-function variants 15461 18015 101809 114715 114716 18176 EUKARYOTIC TRANSLATION INITIATION%REACTOME%R-HSA-72613.5 Eukaryotic Translation Initiation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 75705 13685 13684 208643 217869 226982 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 13665 67204 108067 217715 26905 13667 209354 224045 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 18458 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME%R-HSA-168274.5 Export of Viral Ribonucleoproteins from Nucleus 18141 107939 69482 71805 54563 19069 70699 72787 103573 18226 218210 193740 69912 103468 19386 234865 59015 69736 110379 19384 170762 108989 231042 227699 223921 227720 445007 269113 66679 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399719 Trafficking of AMPA receptors 53623 14799 17246 243547 14802 238276 18693 11771 12322 12323 108058 12325 18751 14800 54377 21912 13385 74053 18195 13383 12300 54376 18752 81905 17920 18750 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME%R-HSA-9672393.3 Defective F8 binding to von Willebrand factor 14069 22371 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME DATABASE ID RELEASE 96%6791465 Pentose phosphate pathway disease 19895 21351 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME DATABASE ID RELEASE 96%69052 Switching of origins to a post-replicative state 52717 56436 99152 17463 668450 67177 57296 23834 20422 26445 26446 57441 19172 19173 19175 19177 21402 56438 26443 26444 12566 19170 12447 66413 26965 56371 667035 27401 22190 12448 59029 67089 70247 12428 17216 17215 17217 17218 17219 17220 50793 18392 18393 66634 26428 26429 56452 12427 21762 22123 19179 19181 19182 217232 23996 56317 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%901042 Calnexin calreticulin cycle 193670 227619 54197 19089 116891 20338 74126 66967 192193 12317 223455 66597 14827 320011 23802 22644 216440 66435 108687 75841 12330 667035 22190 14376 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND LUMINAL EPITHELIAL CELLS%REACTOME%R-HSA-9927418.2 Developmental Lineage of Mammary Gland Luminal Epithelial Cells 11839 21802 13645 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.5 MicroRNA (miRNA) biogenesis 20020 231329 20021 69241 17749 236511 100043714 192119 94223 23992 21357 75284 72322 14000 66420 214150 19384 69833 67710 245841 69920 20022 76850 239528 NTRK2 ACTIVATES RAC1%REACTOME DATABASE ID RELEASE 96%9032759 NTRK2 activates RAC1 19353 18212 208869 12064 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 96%9678110 Attachment and Entry 269523 50528 70008 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.3 Defective SERPING1 causes hereditary angioedema 58992 16621 12258 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%73857 RNA Polymerase II Transcription 20682 12389 12640 269061 18550 20869 64930 66508 545987 54170 22084 52187 68576 66096 83409 74370 68441 19042 268706 83701 245670 20683 18044 18045 18046 14732 14102 12362 16396 670717 56424 21933 22061 12028 64144 20926 93736 70122 74427 73473 12322 12323 108058 12325 18747 12418 77683 22166 12151 17248 17165 19763 12428 17246 54383 13619 110147 26399 241915 12416 19821 12579 12578 16193 494448 12427 12608 30951 12064 14812 13388 16449 384091 666609 27374 20638 56698 67332 29813 59092 50883 228829 12326 14811 20620 70625 68975 227644 13865 243963 77634 234959 20841 12419 102209 21418 330959 76184 75627 94112 15213 67268 70208 17988 21849 69020 13649 21802 14723 55948 94093 228876 15111 67731 268417 14751 23942 209225 56771 50493 21825 80509 104625 22160 21815 67911 214669 226896 240068 13395 108083 21833 15257 13038 77827 18983 98386 13039 210104 384763 239985 72611 269704 12702 14462 16854 14461 228839 14460 71361 14463 16477 233107 14776 56310 72780 237775 208043 26896 14800 15258 218772 19411 103988 52897 75747 80707 54526 16880 14534 17700 244556 12857 110109 619310 12450 12452 69131 30944 237758 53621 110323 19664 72068 229543 14579 70422 12861 109077 232791 68510 19650 71177 17863 18987 19651 210925 12862 109019 17865 18130 12868 75137 68943 77065 66142 269344 216848 69917 232232 93697 12866 68991 12865 192657 233056 69882 100041785 72656 208836 231571 77519 218333 109648 71957 18129 101861 18131 70885 170936 71793 18132 225283 107932 57432 666581 70470 12662 675812 72119 243834 170787 18148 53376 19211 333182 22775 239546 230899 75605 68428 16184 216456 16183 434377 66494 110052 100039786 19712 19713 71131 619331 26992 243906 15510 22648 381549 71063 319974 68742 235682 68094 83796 83797 57376 72720 19246 243743 244713 544922 380975 72306 268936 229542 434178 22658 12705 22750 17684 23988 67279 19258 72154 59027 67057 225872 17283 17992 69076 18718 18741 74400 15228 56353 230162 72723 22704 14229 22757 226830 70315 21349 210135 93836 193452 18986 11864 67821 244349 80902 13866 13864 74747 210503 93681 57264 232784 330301 74120 18519 449521 245368 15370 109594 17702 22654 16909 11783 56707 16825 57745 69562 242109 64384 22761 30942 15378 195522 77044 18534 103836 22632 20750 269870 12020 20393 20375 22696 18854 245595 56314 353187 70227 79221 110616 11816 59024 327987 72180 236193 432769 66105 67296 52712 231866 233904 22294 20135 234725 192292 83766 80751 23957 21907 11350 20482 20492 74570 72290 20481 116748 20183 20182 71041 75410 101095 238690 17125 17126 17127 17128 69181 75692 76073 17192 12741 66313 17130 21981 17131 17132 228140 67235 268859 56744 103806 56525 14312 16600 70088 13496 53325 69125 22640 209456 11604 219024 228491 219103 333639 22284 56456 18124 66813 53892 22062 319801 213011 223272 99890 69790 22678 68527 58184 19885 243372 22026 225998 52679 50496 22608 13559 104394 241764 12858 93760 233893 66923 107986 353310 76390 21762 13198 22123 14634 13197 14633 19179 57748 19181 14660 19182 67956 23996 268973 19184 75788 18033 230784 26440 16653 19166 170826 20463 19167 170574 12981 26441 12978 74352 26442 64050 69077 76367 66997 381022 23997 69260 14381 56436 14377 17463 78893 57296 19293 20422 70472 26445 16334 26446 327963 19172 69228 19173 225655 19175 56458 19697 239652 19177 52846 21402 94223 78251 26443 21388 26444 18091 332937 19170 21423 231464 232854 66413 22709 26965 16179 667035 18387 22190 18390 18751 64058 240064 59029 21408 13983 67089 75613 14219 70247 21406 68744 22260 17708 20181 17709 22337 17710 19013 22693 16408 13982 12795 22025 14431 19883 26913 11835 72739 18227 72556 14815 26381 272347 26380 208727 26379 19016 57913 22196 16399 12366 16401 26423 16402 19401 106931 12368 21834 20787 18667 233060 69234 19360 56338 13831 264064 17535 12053 21975 12359 18022 19364 84682 27354 15978 12021 12843 12842 20807 81601 56187 327762 54601 19352 17386 19361 330463 170740 243621 22427 333654 12399 19718 192651 69263 20371 15574 20604 11920 16009 16006 12189 83814 22689 235610 68036 231724 12227 237911 15185 19355 12122 66262 225182 12142 15184 26909 22751 18538 27274 235559 11863 17433 12144 20527 216154 68275 20467 106344 78783 72151 211651 14088 68240 51813 12156 252870 19891 72230 15469 212712 12177 19367 69792 19356 12417 15205 20878 20466 12649 108961 217232 18996 56317 18997 59008 67381 19015 66156 72805 216080 12905 69957 219022 17222 22339 75430 56222 68612 666311 52563 15182 22194 71393 68999 15194 52206 12226 100039535 319530 52717 244219 99152 22690 668450 17187 12534 100041581 56275 12387 20602 11906 23989 67155 20586 170753 20779 20588 20587 56461 17295 60599 67338 270118 235956 13345 21936 241196 235028 26416 433766 66214 12005 29808 16656 234366 26413 18787 26417 240087 77976 12545 107568 67370 28077 56233 19094 234594 382985 15214 244216 54401 171285 21420 21419 19014 11865 328572 21372 19017 103573 59035 81004 66993 17260 15183 20185 93759 217166 12914 11909 640703 18019 20656 56484 16476 18477 21672 66899 22627 12569 12568 12125 14103 12532 18128 56438 12918 16147 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 14415 74320 14417 68188 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 12447 56371 27401 13163 12448 12576 73699 11799 19052 19053 51792 20877 26931 76246 214498 66317 235497 22083 54624 18861 17685 17350 21872 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 21679 15267 21676 319168 21678 319167 14281 76850 239528 319186 21677 319178 319183 319182 236511 319190 241113 56717 319176 319181 213988 217351 56637 214150 227743 19247 14056 17454 319169 109270 105787 108079 20846 19079 108097 625328 78303 319188 15270 19082 56716 624153 23797 382522 233833 21415 232440 13626 319149 22628 16842 22612 11651 11652 15077 66310 140858 97064 52615 19646 213464 214162 13001 13000 100039026 17869 245688 22601 23808 78757 108099 12477 18607 21414 21416 231051 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 229906 235459 24074 83602 58202 68153 74197 67923 27224 27632 24116 12455 72949 13716 63856 22059 21803 54188 11545 54196 69257 13709 12143 18507 12400 225207 20674 22065 18761 22631 22629 18976 433759 16590 COMPLEX III ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9865881 Complex III assembly 72795 107197 66445 67003 22273 66694 15526 100042918 66576 14297 67530 544717 56046 100040287 380840 17711 22272 66152 75530 67267 56384 66821 100900 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 96%5218921 VEGFR2 mediated cell proliferation 18762 640703 16440 18753 18176 218397 15461 18803 16542 20698 18751 18750 229709 16438 16439 18607 DEFECTIVE MUTYH SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9608287 Defective MUTYH substrate binding SIGNALING BY GPCR%REACTOME%R-HSA-372790.7 Signaling by GPCR 17202 17201 20779 22094 12640 18754 18755 320127 26413 76192 26417 104418 56077 66082 22325 231871 380921 110524 269060 110197 217480 13139 331374 140498 212108 57257 19773 242093 18176 381489 20662 19877 239336 16336 15461 23919 52666 16800 13605 109689 19878 216869 213498 207212 71704 234094 56349 16801 11852 75547 72754 69632 213649 24001 224014 230098 53972 30938 21390 77669 442801 226970 235611 54126 101497 14673 269608 640703 328967 14163 19055 26382 19056 268739 19419 14674 73341 11550 11853 19058 11548 11549 12568 11820 109934 11554 11555 11556 15560 15559 15558 213788 15557 13492 57265 382348 13733 13491 381853 13490 14607 13489 22226 13488 14697 111174 93897 215855 19206 503558 54598 215854 22412 12672 216795 12671 19226 15552 14710 15466 14699 15551 66066 15550 14700 243764 22410 12669 93896 15465 22414 99296 22411 18241 14708 209512 14706 15566 22409 15565 12310 15563 14704 15562 11516 225192 14695 14652 11517 12311 14693 20423 64337 14709 15874 12921 12919 22417 12918 14701 114640 223780 54409 19227 19228 56089 213527 51801 13363 14602 14601 319757 11535 14702 93735 83428 14696 14527 14526 14367 14365 19088 26364 14362 22415 19108 14366 22413 12267 22416 22420 22418 104110 14370 22354 14678 22422 14677 13609 14371 12229 22421 22353 14687 20287 14368 14679 22423 432530 14369 210044 22355 104111 20890 19057 19207 14688 22408 16147 70086 224129 11512 11513 11514 11515 18749 11541 242851 19085 58861 12322 12323 108058 12325 229709 16438 16439 18798 18747 16440 73699 110651 20112 19052 19053 51792 21770 14680 55984 20293 19418 54393 23939 21844 207565 18752 236915 242425 18429 11998 18430 54140 26361 12000 14685 212541 20210 15139 12266 104709 207911 18750 23797 18796 18797 14686 18795 12326 320207 19084 11651 11652 22324 18710 13649 14419 12772 12774 12768 30955 80901 18708 14747 18709 84112 18479 20607 387512 59289 18706 12776 18607 12775 12458 12773 12771 170458 18386 18389 14539 23925 19214 243270 239283 387513 19222 14427 19217 18166 19218 19219 18167 18168 14294 12802 14293 12801 14309 387353 387515 353148 12765 227288 14308 56838 57811 17773 244701 353165 387348 387356 19156 20605 19065 20606 19064 211578 80885 272031 12145 20609 20608 14428 13051 227289 75769 217212 208990 216152 22439 110326 83770 20132 140795 57349 17171 30878 623503 107522 17329 20290 11848 17200 102098 18155 55985 20303 109648 20304 12057 20306 14675 20296 20292 24012 20302 57385 19739 20295 20297 100039973 74191 50782 100038965 277360 20299 13610 56066 20311 50779 20312 20300 11539 11540 18610 18619 229791 235044 11542 252837 66102 13611 14672 622434 22095 330122 51791 14823 12922 14608 16412 108073 67839 545156 268934 23984 16443 94226 241489 14676 108069 19049 108068 67792 20310 58175 14825 18545 353344 218461 14429 18577 17207 14764 110385 13603 238871 11609 207728 23796 54611 14682 83771 18584 574417 67865 387347 71729 57253 18583 12777 80910 57254 381413 109904 387355 93690 387342 238725 230972 387349 626596 226278 71223 12766 239530 226304 383563 387616 76123 321019 29863 12778 14761 381073 26385 110168 106512 75805 223435 436440 76854 12769 64095 15199 230857 23945 14763 54199 70839 19045 171469 16866 16867 227326 14739 12854 13349 16952 15945 20315 12767 19087 20663 14459 53978 22044 22045 624910 57260 233571 235036 246709 13617 19734 30044 14715 14714 13615 18441 246691 18442 100039592 14745 16963 16995 208188 229214 56183 56696 210198 58182 19204 104443 224065 19216 19220 64214 319239 14816 14289 12374 108071 238377 14744 225642 50778 56744 19735 50780 19736 14829 67168 21333 11606 11607 12061 12062 17392 56470 216749 21338 19737 14064 65086 14063 14062 14061 21337 15200 23832 319197 21334 21336 240816 12424 12425 12426 217369 227717 14065 381810 107221 280287 24111 574402 78134 100043254 237362 385643 433292 246313 233079 233080 233081 50501 67405 18216 14773 54615 12209 78826 114229 15171 110312 18217 387285 230777 11551 14767 11552 68039 11553 18101 56533 18576 22065 18387 18390 18751 22068 26946 18753 18783 110355 18575 18574 18573 16402 319430 12273 20604 18761 19395 20111 320129 13616 13614 18976 17199 13618 17203 DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME DATABASE ID RELEASE 96%5579031 Defective ACTH causes obesity and POMCD 18976 17200 ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 96%2426168 Activation of gene expression by SREBF (SREBP) 73166 110196 14137 14104 100040592 21372 20683 109151 18044 18045 17977 18046 235293 68603 14732 17978 59035 20775 81004 20249 66993 192156 170439 13121 20788 13360 107476 100705 14593 16987 17764 12914 20181 319554 56406 17855 19013 19014 229003 NUCLEOTIDE CATABOLISM DEFECTS%REACTOME%R-HSA-9735786.3 Nucleotide catabolism defects 18950 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME%R-HSA-933543.5 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 16151 14082 71586 230073 12370 12675 16150 71956 228607 19766 217069 MLL4 AND MLL3 COMPLEXES REGULATE EXPRESSION OF PPARG TARGET GENES IN ADIPOGENESIS AND HEPATIC STEATOSIS%REACTOME%R-HSA-9841922.2 MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis 232440 20602 319149 23989 19645 66853 59024 11450 14732 18631 327987 15077 57435 20249 68801 66310 21835 140858 14311 68975 14081 234959 213464 12606 20181 11350 28077 70208 12491 21664 55982 171285 23808 11520 56771 15267 319168 319167 19014 264064 319186 319178 328572 319183 319182 67279 319190 21372 16475 231051 57875 17977 67278 23945 319176 19017 16890 16956 319181 17978 81004 14245 69790 56310 103968 26896 15183 20185 93759 17979 216154 67800 12914 56406 51813 11770 26424 319169 22289 27273 69792 67512 625328 67381 78303 319188 15270 170826 12568 624153 381022 382522 SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 96%2408522 Selenoamino acid metabolism 622534 238217 16785 666669 100040021 67025 100043391 668182 107508 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 50493 667618 100040970 267019 56040 67248 100040331 67941 12411 57294 107869 11720 269378 18113 140483 667035 21743 214580 20768 211006 50880 20226 14711 65967 75420 27207 67097 670832 633683 20044 27050 667279 107045 20085 226414 668144 97541 20084 67186 216443 382492 20055 75617 27370 65019 105148 629957 20102 231872 20103 66143 668668 667739 672214 66481 23971 225058 23972 100038875 104458 100038991 68028 100043000 85305 67891 100043295 13722 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.3 Biosynthesis of DPAn-3-derived protectins and resolvins 11687 11689 DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 96%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) 246049 PENTOSE PHOSPHATE PATHWAY%REACTOME%R-HSA-71336.8 Pentose phosphate pathway 14381 19895 66646 21881 110639 21351 19139 66681 74637 66171 232449 71336 110208 75456 CTNNB1 S37 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358749.4 CTNNB1 S37 mutants aren't phosphorylated 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.5 Defective CFTR causes cystic fibrosis 56436 17463 57296 193670 20422 54197 26445 26446 19172 19173 19175 19177 70377 26443 216440 26444 19170 269523 66413 667035 22190 59029 67089 70247 66753 67819 116891 20338 21762 22123 12638 19179 19181 244373 19182 23996 19184 26440 19166 19167 26441 226144 26442 69077 66997 23997 RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 96%159418 Recycling of bile acids and salts 76408 20181 12012 20186 17977 20494 20493 28253 106407 17978 330962 26459 170460 27413 11657 16204 28250 SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.5 Signaling by RAS mutants 16706 20779 12322 109880 12323 108058 12325 26413 26417 12988 109905 640703 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 16653 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME DATABASE ID RELEASE 96%5218920 VEGFR2 mediated vascular permeability 12385 12388 12387 18127 12562 18481 56717 11651 12389 11652 19353 22324 227743 15519 22325 640703 109270 57257 78757 228775 224105 16480 56716 75778 18479 23797 18607 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 96%5607761 Dectin-1 mediated noncanonical NF-kB signaling 12234 56436 53859 17463 57296 20422 26445 26446 19172 19173 19175 19697 19698 19177 21402 18034 26443 26444 19170 66413 26965 667035 22190 59029 67089 103583 70247 22200 21762 22123 12675 19179 22192 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013149 RAC1 GTPase cycle 214230 18806 330319 76884 20663 12389 22324 241656 18710 22325 57257 29875 20662 52666 13605 226751 76088 18708 18709 18479 213498 12704 18706 234094 98386 50768 64652 18481 404710 19418 320795 109333 213649 24001 230098 53972 66508 442801 226970 54126 101497 14674 73341 21844 208869 105827 195727 210293 50884 22042 83767 213522 329165 109934 106952 20401 71893 233071 16449 26934 75974 110279 12549 330177 58996 102098 105855 242687 56513 216963 239027 17969 20947 212285 237038 74018 70497 244867 11308 22319 20619 11855 224480 319899 277360 192662 13058 57778 263406 241275 11857 13057 108100 68813 76117 216445 19349 218952 69710 18805 26431 17970 70584 101314 216831 56418 17972 66898 70719 71302 71544 233103 229658 544963 232201 78816 227377 16412 545156 231532 13726 23943 75739 225358 17207 214137 94176 75415 330662 171207 94190 16709 218581 84004 21917 56699 214804 224105 109904 238130 223254 20430 102075 56419 380664 104445 13836 19765 259302 59079 223666 69922 14270 223435 117600 330914 232906 71435 228359 213783 100038946 23853 73178 19353 219140 226652 20514 232237 78514 245880 22376 215280 11352 68524 17925 67299 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME DATABASE ID RELEASE 96%5579013 Defective CYP7B1 causes SPG5A and CBAS3 13123 G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69275 G2 M Transition 20873 68121 56299 29870 12534 78887 12575 217653 22628 100038822 225745 231123 12566 74360 18536 56371 66296 214552 19646 18541 75786 15519 18747 21664 71909 237222 73699 17997 18005 19052 73738 19053 68475 51792 53598 208518 236266 15516 328572 12009 99100 103733 22154 12428 74470 104318 56455 101565 16328 219103 108000 259279 103573 83922 171567 51885 72415 26370 76789 72083 76707 233276 103768 74237 13589 18472 12427 21762 12442 22123 19179 19181 19182 23996 19184 26440 19166 13427 19167 22627 26441 17931 22390 13424 26442 17865 72568 69077 66997 12530 231506 23997 12531 27373 629959 12234 56436 12532 17463 75660 57296 20422 26445 26446 19172 15366 19173 19175 268930 19177 21402 56438 26443 26444 227613 19170 72119 22153 66413 26965 667035 22190 22142 59029 67089 103583 70247 66671 17420 22145 12572 22059 14235 100986 16475 19088 230376 69654 231863 71648 17274 75296 72590 30949 77011 72486 19046 12537 77744 219072 225659 76478 78177 28135 214444 71978 76816 20878 54130 18817 381644 448987 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.5 SLBP independent Processing of Histone Pre-mRNAs 72290 116748 20638 384091 666609 243963 68092 67332 433702 RHO GTPASES ACTIVATE FORMINS%REACTOME DATABASE ID RELEASE 96%5663220 RHO GTPases Activate Formins 223701 18643 18645 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 11465 73804 19053 22379 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 11852 26951 13367 108000 229841 12237 103573 12617 107995 72415 83815 208846 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 11853 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 13426 52504 13424 228421 11848 71409 57778 11461 16412 56419 20807 14270 19353 11854 320271 13542 13544 13543 18817 14026 APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME%R-HSA-174048.4 APC C:Cdc20 mediated degradation of Cyclin B 52717 99152 668450 12534 107995 217232 56317 59008 66156 667035 216080 22190 69957 17222 75430 68612 52563 22194 68999 52206 100039535 METABOLISM OF COFACTORS%REACTOME DATABASE ID RELEASE 96%8978934 Metabolism of cofactors 18127 11651 11428 20751 71365 67426 99138 320415 15519 14528 242642 76889 217707 230027 640703 67914 19286 56075 12850 71883 227683 52064 13361 15926 19092 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 96%9635486 Infection with Mycobacterium tuberculosis 672511 12721 16646 15239 19720 13806 233405 667035 22190 19349 18126 26413 26417 108664 71514 18655 16211 70686 606496 271457 12010 13035 17002 24088 17533 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 96%5576890 Phase 3 - rapid repolarisation 16511 16493 57814 246133 100986 16535 66240 16509 57442 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.4 Sema3A PAK dependent Axon repulsion 12631 14159 18481 18845 18186 18844 19353 18846 16885 243743 224105 20346 18479 15516 14360 15519 FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190372 FGFR3c ligand binding and activation 14172 80857 14425 14180 80903 64654 14175 14173 14164 RHO GTPASE EFFECTORS%REACTOME DATABASE ID RELEASE 96%195258 RHO GTPase Effectors 232440 12387 12550 319149 22628 381293 76804 15077 17886 26416 26413 26417 67268 19094 54401 55948 12638 29875 19877 263803 11465 52428 20166 19878 18479 12704 18607 18481 11852 404710 13367 16594 103573 232943 320795 17978 109333 208846 16593 19354 20201 74764 20202 640703 11853 22627 50884 83767 329165 71893 12532 18762 11848 105855 242687 17969 237038 77579 11308 71960 224480 16885 13058 16886 241275 13057 108100 11461 17970 101314 17972 544963 100039786 16572 16573 16412 13385 16709 20430 192176 56419 12385 23988 67938 17904 107589 56212 17283 17880 76709 73178 12229 19046 56443 320271 99982 80987 68089 67771 11867 56378 66713 74117 13542 245880 13544 14083 18016 13543 76378 22376 100039683 215280 233406 68524 14026 17973 223701 330319 76884 18643 18645 12576 108911 73470 16563 75786 70454 216965 11350 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 73804 19053 22379 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 329251 13426 68458 52504 17931 13424 75669 228421 22342 225326 71409 57778 18751 11835 18753 15267 319168 319167 224105 319186 319178 319183 319182 20807 14270 319190 94221 13043 319176 319181 19353 14787 11854 12631 319169 22631 22629 625328 78303 18817 319188 15270 18750 624153 382522 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 96%2046106 alpha-linolenic acid (ALA) metabolism 11666 15488 113868 68801 54326 170789 56473 76267 54325 20280 12686 14081 TGFBR3 PTM REGULATION%REACTOME%R-HSA-9839383.1 TGFBR3 PTM regulation 21814 100042305 208117 59287 100039623 17387 17389 21858 21857 19164 19165 TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.5 Triglyceride catabolism 18747 14571 14079 19047 14080 75772 11770 23945 75497 16890 19045 12389 18749 21884 67469 19046 103968 66905 12140 16204 16592 14077 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.3 Cross-presentation of particulate exogenous antigens (phagosomes) 16419 12491 13058 13057 17969 17970 17972 16410 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 96%177504 Retrograde neurotrophin signalling 18211 232910 11773 13430 54152 20404 11771 11772 103967 71770 67300 13429 12757 18049 NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 332937 80707 106931 233107 21420 21419 226896 21418 22196 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-HSA-9006931.7 Signaling by Nuclear Receptors 233833 232440 20602 319149 268980 20779 16478 11651 12389 11652 15077 18710 12005 26413 26417 28200 17869 13649 21802 18176 15461 67484 218214 11815 320982 104263 18708 19014 18709 15516 18706 18607 328572 17395 21372 18127 17977 14462 103573 21374 17978 59035 81004 56310 268903 107951 15183 20185 218772 19411 12914 11909 235459 640703 83602 68263 228026 18604 236900 27273 12455 27402 16001 56484 16476 18597 18598 17863 235339 18762 20683 14732 20249 14697 13610 13382 14710 14699 66066 14700 14708 14706 14704 19060 14695 14693 64337 14709 14701 230674 20698 12705 14702 30924 14696 20148 19378 237320 13082 98711 11307 12903 56847 22259 19682 242285 105014 232174 11303 216454 546726 17252 14678 108841 14677 241452 14229 105349 218203 103968 67393 12648 14679 13033 99982 16204 14228 16592 18986 17979 193796 14688 228913 13207 21887 15375 55960 268527 107351 11812 26424 21786 11813 22282 22278 18519 11425 100041004 100043508 14083 68268 12904 12390 20315 17393 22236 102193 67738 242851 18534 22632 11816 12443 12576 15519 100039592 20183 20182 20842 24061 19357 12400 14104 17392 12223 16589 71920 13874 13712 15200 13006 11839 12043 13645 20843 68705 98053 66420 69833 67710 245841 69920 13983 20022 22260 20020 20181 231329 20021 69241 13982 17749 100043714 11668 19401 15267 319168 18667 319167 14281 76850 239528 319186 319178 319183 319182 20807 81601 236511 319190 14282 319176 319181 213988 11522 26876 217351 214150 17454 17390 319169 15469 67470 27409 625328 78303 319188 19015 15270 433759 624153 71393 23797 382522 FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 96%1839124 FGFR1 mutant receptor activation 14389 80857 110279 14180 14177 64654 14175 14173 20851 14164 20850 75296 360013 432508 67529 13047 76007 14182 67384 20846 20848 244373 21848 18708 18706 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME%R-HSA-5693554.3 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 12021 81601 327762 20422 269400 19361 114714 22427 11920 12189 12190 237911 57434 225182 74335 26909 12144 233826 19362 19360 17535 21975 19363 19364 27354 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.6 Collagen biosynthesis and modifying enzymes 26432 26433 210530 56401 76477 18542 234407 12817 12816 12815 24087 12814 21892 12831 12153 12813 94216 12830 373864 12821 107581 77018 12819 53867 12829 12828 12827 12826 12825 69700 12824 12822 71355 12841 12823 73368 12840 213945 12818 245026 140709 237759 12839 329941 12837 12836 12835 12834 12833 12843 12832 12842 18453 18452 19035 18451 320452 56693 269132 237360 14789 330119 12406 216725 18822 HIV INFECTION%REACTOME%R-HSA-162906.4 HIV Infection 18108 107305 72543 194309 14360 52348 116733 73711 22088 67123 330192 76959 66201 20479 66914 12504 100088 12774 19385 18107 12487 270627 68092 228980 319944 103573 21374 433702 20922 20833 216185 108143 18550 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 108664 21343 209361 226182 12454 229906 235459 24074 268373 83602 58202 68153 74197 67923 27224 27632 24116 12455 72949 13716 63856 56438 18148 66371 108138 94176 68953 75608 319583 18571 15162 12526 170762 140580 108989 231042 227699 208092 223921 227720 66700 269113 66679 18141 23825 107939 69482 71805 11739 433923 11740 54563 16646 19069 15361 70699 101739 72787 18226 218210 11771 105513 11772 71770 232910 11773 12767 16881 16211 19386 19384 445007 11840 69912 103468 234865 21762 22123 59015 19179 69736 19181 19182 23996 19184 110379 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 14156 26446 19172 19173 19175 19177 21402 26443 26444 19170 66413 68705 98053 667035 13871 22190 66420 69833 67710 59029 245841 69920 67089 20022 14885 70247 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 15007 12010 224105 11768 11769 108012 11764 107975 11765 11767 252903 19353 83814 22596 14375 75717 16818 DRUG RESISTANCE OF ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9700649 Drug resistance of ALK mutants 11682 IKBKB DEFICIENCY CAUSES SCID%REACTOME%R-HSA-5602636.3 IKBKB deficiency causes SCID 16151 12675 16150 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 96%187024 NGF-independant TRKA activation 18212 18211 11516 11517 11540 FRS-MEDIATED FGFR4 SIGNALING%REACTOME%R-HSA-5654712.5 FRS-mediated FGFR4 signaling 327826 14172 80857 14170 14180 14177 64654 14175 18176 20662 14173 14164 15461 83379 107971 80903 19247 14186 KETONE BODY CATABOLISM%REACTOME%R-HSA-77108.6 Ketone body catabolism 110446 71911 67041 64059 NUCLEOTIDE METABOLISM%REACTOME%R-HSA-15869.7 Nucleotide metabolism 57813 67464 108147 69719 12495 11564 11566 12496 12497 215446 14544 231327 237823 53893 67365 66358 72090 67725 75686 22247 66422 80914 320685 22245 93692 68556 18102 55936 76952 18103 20133 381101 20135 229363 66588 93685 78801 11565 51797 72269 21915 56749 11636 16434 22436 11637 67054 229949 14450 214254 635960 79059 56520 15452 54369 382985 68870 100042069 23917 14923 22171 21877 56045 50493 22166 64705 76654 72962 99586 103149 230718 268782 50773 103850 22271 12499 75894 18950 229665 109674 11717 105446 11534 11486 11821 66355 13178 27369 23959 CELLULAR RESPONSE TO STARVATION%REACTOME%R-HSA-9711097.5 Cellular response to starvation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 11910 100039316 22121 17168 216805 101142 230676 27103 100043876 270802 100043893 98402 100043423 268933 100042986 56032 20115 72124 67281 16210 71962 76846 216742 625646 319481 100040298 231659 68172 101148 100042740 277854 19951 252875 228775 70394 667618 100040970 267019 56040 67248 100040331 67941 27053 57294 11911 12611 242341 68775 140742 66508 76252 545987 11972 108664 66290 54170 11909 11964 52187 68576 110935 66096 11966 83409 100039636 74370 66335 68441 11973 12608 11974 13198 268706 74915 338375 245670 73834 114143 66237 230784 110379 27060 66144 667035 13665 67204 26905 56717 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 56716 100038991 68028 100043000 67891 100043295 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME DATABASE ID RELEASE 96%140534 Ligand-dependent caspase activation 14103 17087 22030 12475 21933 225471 106759 14102 21898 71609 14082 22035 12370 19766 RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 96%8941856 RUNX3 regulates NOTCH signaling 270118 328572 12914 16449 19664 14534 18519 12399 18128 333639 103806 15205 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963896 HDL assembly 11303 18747 232345 11806 27801 18749 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.5 Inositol transporters 233836 239606 53881 KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.4 Keratan sulfate keratin metabolism 18295 244757 72297 14595 17022 75612 56336 56386 108902 14264 70484 53374 16545 227327 231727 53625 54613 116847 50917 57370 53418 56375 76969 54371 56773 20444 20442 70893 20443 15212 15211 27047 12091 MITOCHONDRIAL MRNA MODIFICATION%REACTOME DATABASE ID RELEASE 96%9937008 Mitochondrial mRNA modification 75619 227682 83485 94254 380773 66410 67440 72416 71989 101122 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.2 Biosynthesis of aspirin-triggered D-series resolvins 16993 11689 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%156580 Phase II - Conjugation of compounds 71522 207182 56615 211666 66447 22021 70484 22022 117147 76263 22017 14863 107146 216558 233799 233801 272428 435528 69065 75475 13885 14872 17961 54486 94215 68252 72094 66054 58810 213012 14862 14630 394436 14865 394433 14866 22235 68312 71773 100042314 100727 14874 100559 14871 231396 68044 394434 68214 94284 552899 223337 242585 17960 13077 14859 14629 76491 56362 319655 20859 67768 242291 108645 20860 57344 23827 67883 67674 73671 238505 29859 11720 20887 232087 210009 14873 14598 269378 14854 18113 12846 22236 23887 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%R-HSA-3656535.3 TGFBR1 LBD Mutants in Cancer 21803 21812 21813 14225 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME DATABASE ID RELEASE 96%9690406 Transcriptional regulation of testis differentiation 22431 26423 20682 14463 14180 50796 11705 19215 13363 22762 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME%R-HSA-110313.3 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template 22230 56791 59001 74153 19687 100038882 19718 69263 22224 19714 66979 244666 269523 71890 26447 56210 68026 216835 667035 22190 68098 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 80905 67967 217069 217365 27015 69745 UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME DATABASE ID RELEASE 96%5336415 Uptake and function of diphtheria toxin 15200 50493 13629 15516 12527 15519 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702998 linifanib-resistant FLT3 mutants 14255 N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 96%964739 N-glycan trimming and elongation in the cis-Golgi 242362 17155 17156 17308 230815 INTERLEUKIN-36 PATHWAY%REACTOME DATABASE ID RELEASE 96%9014826 Interleukin-36 pathway 54450 107527 215257 215274 54448 69677 PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 96%2160456 Phenylketonuria 18478 SYNTHESIS OF PC%REACTOME DATABASE ID RELEASE 96%1483191 Synthesis of PC 100434 213603 242259 70129 68682 64899 14245 99712 64898 236899 12651 237928 56018 99138 212862 12660 13026 76574 13001 106861 13000 18559 100039026 18618 12038 12647 11423 210992 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190377 FGFR2b ligand binding and activation 14181 72514 14178 67112 14174 14165 14173 14164 AMPK-INDUCED ERAD AND LYSOSOME MEDIATED DEGRADATION OF PD-L1(CD274)%REACTOME%R-HSA-9931269.1 AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 269523 66413 667035 22190 59029 67089 70247 244373 60533 108099 226144 193670 54197 241113 70377 216440 66753 67819 116891 20338 21762 22123 105787 108079 19179 19079 19181 19182 108097 23996 19184 26440 19166 19167 19082 26441 26442 69077 66997 23997 UNCOATING OF THE HIV VIRION%REACTOME%R-HSA-162585.3 Uncoating of the HIV Virion 268373 BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.2 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) 17001 14865 DEFECTIVE B4GALT1 CAUSES CDG-2D%REACTOME DATABASE ID RELEASE 96%4793953 Defective B4GALT1 causes CDG-2d 14595 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME DATABASE ID RELEASE 96%5099900 WNT5A-dependent internalization of FZD4 232910 11773 14366 13543 22418 11771 11772 18752 71770 67300 12757 18751 216869 18750 74325 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8939902.4 Regulation of RUNX2 expression and activity 56436 17463 57296 12020 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 27401 22190 59029 16656 67089 70247 107568 13982 14815 26379 22160 13395 12400 56424 19017 56637 12156 21762 22123 20846 19179 17702 19181 19182 23996 19184 75788 26440 19166 170826 19167 26441 26442 69077 66997 23997 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME%R-HSA-5687868.4 Defective SFTPA2 causes IPF PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME DATABASE ID RELEASE 96%9636383 Prevention of phagosomal-lysosomal fusion 233405 271457 667035 22190 12721 19349 15239 NEUROPILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME DATABASE ID RELEASE 96%194306 Neuropilin interactions with VEGF and VEGFR 14254 18187 16542 18186 ENOS ACTIVATION%REACTOME%R-HSA-203615.6 eNOS activation 640703 69219 114886 18127 66427 18777 18108 12389 11651 68268 20751 18107 15519 TNF SIGNALING%REACTOME%R-HSA-75893.10 TNF signaling 22241 56480 11491 16150 16151 14694 66105 53376 667035 22190 26409 67384 21937 30941 22029 229603 22258 17164 268749 106025 21926 74256 263876 21929 76580 22195 24105 12370 19766 11797 22030 56424 56489 11796 11798 71648 100041766 71609 14082 66513 66724 68652 66552 76686 432940 20598 12675 52440 58994 18201 73218 216080 RAS PROCESSING%REACTOME%R-HSA-9648002.4 RAS processing 110606 57295 640703 14272 208884 18777 18176 18582 15461 70178 226016 57437 19671 436004 16653 56327 216169 12048 18761 19092 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 2 CELLS (TH2 CELLS)%REACTOME DATABASE ID RELEASE 96%9976102 Differentiation of naive CD4+ T cells to T helper 2 cells (Th2 cells) 216848 22632 232232 20602 18129 20586 20230 18128 79221 107932 16364 270118 170787 66310 140858 19646 234366 213464 214162 56233 245688 208727 23808 12418 23942 16189 17192 16163 17132 14281 103806 229542 12151 328572 19763 21372 54383 13619 17283 333639 241915 14462 16190 12416 20851 20850 81004 20852 15185 19821 70315 15184 15183 116871 20185 18986 116870 12914 23871 494448 14534 18019 18519 30951 53314 19664 16476 433759 16191 50794 18987 15182 FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190374 FGFR1c and Klotho ligand binding and activation 64654 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.3 SUMO is proteolytically processed 100043429 75826 223870 320213 20610 VITAMIN E TRANSPORT%REACTOME DATABASE ID RELEASE 96%8877627 Vitamin E transport 50500 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9617828 FOXO-mediated transcription of cell cycle genes 16600 59092 54601 12575 17700 56458 17126 13197 17127 12452 12389 17128 15228 56484 19651 12576 12226 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.3 Mitochondrial tRNA aminoacylation 70560 71984 224805 353172 70791 68915 230577 97541 226539 71807 69955 244141 71941 70120 381314 67417 102436 74776 85305 109093 212679 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9648895 Response of EIF2AK1 (HRI) to heme deficiency 17872 11911 14783 12608 13198 12611 15467 107503 228775 69065 13665 67204 26905 27053 11910 NUCLEAR RNA DECAY%REACTOME DATABASE ID RELEASE 96%9930044 Nuclear RNA decay 72544 50911 69639 210106 72662 66446 227715 68092 24128 216578 664817 433702 112403 76014 225432 231386 67010 240255 70650 216345 50912 74213 214627 57316 72198 68533 77305 54196 83701 66362 109075 66583 27998 VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME DATABASE ID RELEASE 96%195399 VEGF binds to VEGFR leading to receptor dimerization 14205 14254 16542 22341 14257 22339 18654 22340 PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 96%432142 Platelet sensitization by LDL 225849 26931 21770 26932 15170 18613 73699 18783 238055 14191 19052 19053 51792 26416 19247 226849 REGULATION OF ENDOGENOUS RETROELEMENTS BY THE HUMAN SILENCING HUB (HUSH) COMPLEX%REACTOME%R-HSA-9843970.1 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex 319178 319183 319182 232440 319190 319149 110147 319176 74522 319181 15077 75339 67010 70650 223828 72198 319169 54343 625328 77683 15267 78303 319188 319168 15270 319167 84505 624153 319186 382522 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME DATABASE ID RELEASE 96%372708 p130Cas linkage to MAPK signaling for integrins 109905 20779 54519 22371 14083 16399 14268 16416 12927 14161 21894 215449 12928 110135 99571 INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.6 Intracellular metabolism of fatty acids regulates insulin secretion 74205 12491 50790 MEIOTIC RECOMBINATION%REACTOME%R-HSA-912446.7 Meiotic recombination 319178 319183 60530 17350 319182 232440 319190 319149 19361 114714 319176 12567 12566 319181 11920 15077 12189 12190 319152 225182 13404 26972 19183 12144 217716 381306 76915 68275 55993 17687 68240 19891 319169 213389 625328 78303 15267 319188 15270 319168 319167 19360 17535 624153 21975 319186 27354 382522 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF BMAL1 (ARNTL) AND CLOCK%REACTOME DATABASE ID RELEASE 96%9931529 Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCK 13001 100039026 12753 12568 11865 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.5 Signaling by Activin 14106 14313 66556 11481 17126 17127 16323 17128 16322 21814 269275 11479 83554 11480 16324 26413 26417 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 96%264876 Insulin processing 69940 16334 17918 245049 18453 66482 53413 11891 20336 107371 16572 16573 69048 57394 16574 18548 12876 105504 211446 22318 102058 239436 20907 18549 67475 SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.5 Serotonin receptors 15566 15565 15563 15562 15560 15559 15552 15558 15551 15557 15550 DEVELOPMENTAL CELL LINEAGES OF THE INTEGUMENTARY SYSTEM%REACTOME DATABASE ID RELEASE 96%9734779 Developmental Cell Lineages of the Integumentary System 11839 21802 13645 14165 19109 ECM PROTEOGLYCANS%REACTOME%R-HSA-3000178.6 ECM proteoglycans 13138 13406 12111 13004 16420 241226 17022 16398 14264 17182 16404 17967 18787 11603 66695 16412 17183 17180 21960 18198 16775 81877 16776 329278 16777 21923 666279 16779 12950 228357 226519 16411 16399 16416 12841 16772 12840 15891 16773 12845 16774 22370 12839 19280 15530 16419 16410 21803 21808 13003 20692 12032 104099 13179 21809 SLC-MEDIATED TRANSPORT OF NEUROTRANSMITTERS%REACTOME%R-HSA-442660.4 SLC-mediated transport of neurotransmitters 68267 232333 14412 103098 216227 56774 104245 243616 13162 14664 140919 20518 240332 20517 22348 71803 74338 102680 20538 15567 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 96%5579000 Defective CYP1B1 causes Glaucoma 13078 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 96%8941237 Invadopodia formation 11490 11489 14218 11492 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654719 SHC-mediated cascade:FGFR4 14172 80857 14170 14180 14177 64654 14175 18176 20662 14173 14164 15461 83379 80903 14186 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%381070 IRE1alpha activates chaperones 225849 320209 56494 22393 16905 12282 15191 52639 72599 13191 192193 74322 71765 22642 28106 28146 231997 12751 56219 67398 228998 54616 52808 58193 105785 11370 11972 66515 20416 69162 100037258 74126 14583 11518 606496 21894 71853 20818 14828 107513 67838 68090 78943 381801 27362 50907 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.2 Translesion synthesis by POLI 68275 106344 72151 68240 19891 19687 19718 69263 19714 71890 26447 56210 667035 22190 18538 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 96%73728 RNA Polymerase I Promoter Opening 319178 319183 319182 232440 319190 319149 319169 319176 21429 319181 15077 17191 625328 15267 78303 319188 319168 15270 319167 624153 26417 319186 382522 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%9006925 Intracellular signaling by second messengers 233833 13626 12326 268980 18183 83961 320207 100042150 20779 19084 17295 11651 11652 22324 18710 18754 52615 17999 19646 234366 26413 26417 14360 327826 13001 13000 100039026 56233 245688 13649 21802 23942 78757 228775 30955 18708 18709 18706 108083 18607 74769 18707 12487 12519 12524 19354 15183 66508 545987 54170 11909 640703 22084 52187 68576 66096 83409 74370 68441 268706 15234 67605 245670 56484 16476 83490 18596 216848 77647 18213 107932 19211 19712 18595 22059 229542 20613 56424 56212 19088 19108 11798 18718 104110 432530 99982 210044 217864 104111 13866 18720 18719 224129 11512 11513 11514 11515 15370 18749 19085 20393 12575 18854 66894 19087 72607 68031 73162 19720 21951 74493 14302 12322 12323 108058 12325 12576 14255 229709 16438 16439 21907 18747 100039592 16440 73699 12015 12371 12418 19052 17192 19053 51792 14013 12151 226849 225849 26931 19763 21770 26932 17246 54383 13619 55984 12223 241915 12416 71920 13874 15200 211323 19821 77125 494448 21762 30951 22123 12064 12675 14388 17082 19179 19181 18212 207565 19182 23996 18205 19184 78405 99377 18752 26440 18803 19166 11839 19167 13645 26441 80903 384783 26442 69077 14186 66997 14165 23997 14389 56436 16367 17463 14172 57296 80857 20422 26445 16334 14170 26446 19172 14180 19173 14178 19175 56458 14177 67112 19177 64654 14175 14174 26443 14173 26444 14164 83379 19170 17874 66413 16179 667035 22190 59029 13983 67089 70247 266632 13982 18753 110355 18575 18574 19016 18573 244650 13498 68877 98432 58988 15937 12478 75778 76850 239528 18591 54601 236511 56717 16337 13653 19353 213988 217351 56637 14256 214150 227743 15184 19247 22034 116871 116870 104709 20583 14056 18717 17454 252870 109270 606496 433759 16818 16590 56716 18750 15182 23797 54484 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 96%8982491 Glycogen metabolism 640703 13853 56043 77559 216558 72157 68961 18679 667035 105193 110094 22190 102093 232493 14936 74185 110078 27357 110095 18682 19309 14387 53412 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 96%9674403 Regorafenib-resistant PDGFR mutants 18595 REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.4 Regulation of TP53 Expression and Degradation 17248 26931 12534 50883 20393 228829 12428 17246 56717 11651 11652 67338 11920 12566 53376 667035 22190 13163 12142 227743 80751 12578 252870 12427 73699 109270 22059 12450 19052 78757 19053 51792 56716 23797 18607 DEVELOPMENTAL LINEAGE OF MULTIPOTENT PANCREATIC PROGENITOR CELLS%REACTOME%R-HSA-9937080.2 Developmental Lineage of Multipotent Pancreatic Progenitor Cells 14178 13645 14175 14165 14173 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 96%70263 Gluconeogenesis 230163 14377 14385 18648 56012 226265 13806 18563 18663 14121 14120 21991 13808 74551 18655 13807 14447 68401 224674 14751 100043349 11676 18534 11674 14378 MAPK FAMILY SIGNALING CASCADES%REACTOME%R-HSA-5683057.5 MAPK family signaling cascades 233833 16451 12534 208884 18039 18183 14810 83961 11472 100042150 20779 23859 14814 17295 109880 216148 26413 26417 14360 29857 12988 20416 327826 109905 17869 20418 13649 19730 21802 54401 26395 194231 26396 54519 29875 18176 245684 20662 22371 16416 15461 75590 110157 231474 23980 18218 14161 63953 21894 13537 215449 19252 11836 240672 109689 216869 26403 72399 18708 18673 18709 16452 18479 110135 99571 18706 22330 16706 74769 18481 103573 14587 14586 19197 14588 19262 545987 640703 19419 83409 240168 15234 56484 16476 18188 18596 11876 56438 18582 56327 16184 16183 19713 545156 19060 13385 18595 70686 53310 13383 16453 54721 19046 17979 13866 110606 26554 226525 14272 18015 320484 211255 240057 101809 54153 114715 114716 19414 69601 19415 18749 14083 218397 114713 16188 16185 12984 12982 16192 16191 20739 20740 640524 20742 20741 20743 12445 12322 12323 108058 12325 16186 14255 17967 80297 320139 18747 56705 81489 19047 15507 73699 19052 19053 51792 19373 19374 226849 225849 17165 26931 14573 21770 26932 229776 12223 19417 19418 71920 13874 15200 211323 14585 16193 18777 21762 22123 14812 19179 19181 19182 70178 23996 226016 19184 107971 19671 436004 26440 216169 16653 19166 11839 19167 13645 12981 26441 12048 80903 384783 26442 69077 14186 66997 14165 23997 56436 16367 17463 14172 57296 80857 20422 26445 14170 26446 19172 14180 19173 14178 19175 56458 14177 67112 19177 64654 14175 14174 26443 14173 26444 14164 83379 19170 260409 66413 667035 22190 59029 16194 67089 70247 57295 104252 16399 14268 235584 67603 319520 58804 224105 19731 218294 76850 18611 239528 18591 140486 70727 21687 11600 18612 19732 17532 76089 236511 235072 171463 56392 67836 71746 225724 50772 19353 213988 217351 14256 214150 19247 18761 233046 17454 17169 57437 16590 19092 COAGULATION PATHWAY%REACTOME DATABASE ID RELEASE 96%9769740 Coagulation pathway 19152 14066 217847 279028 14068 11905 15160 14058 14071 66901 18787 15529 11603 23888 20971 20969 14723 22371 16399 16416 71951 14161 20970 58992 16621 14735 12258 105722 14724 56744 110135 54368 99571 14729 15530 21824 14060 233246 109821 14062 20720 14061 268591 103978 19124 20597 68891 14733 74145 14067 385643 14734 19123 14069 19128 11820 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619483 Activation of AMPK downstream of NMDARs 207565 108097 640703 108099 19082 241113 105787 108079 19079 CO-INHIBITION BY CTLA4%REACTOME%R-HSA-389513.5 Co-inhibition by CTLA4 225849 26931 21770 12519 26932 12524 73699 17096 22612 11651 11652 19052 19053 51792 16818 19247 23797 14360 12477 226849 SYNTHESIS OF PI%REACTOME DATABASE ID RELEASE 96%1483226 Synthesis of PI 18739 74596 19679 327958 52858 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 96%5693537 Resolution of D-Loop Structures 12021 224008 60530 81601 327762 20422 269400 19361 114714 209334 22427 11920 12189 12190 237911 57434 225182 74335 26909 71711 12144 381306 233826 19362 268465 52864 19360 17535 21975 19363 19364 27354 3-HYDROXYISOBUTYRYL-COA HYDROLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9916722 3-hydroxyisobutyryl-CoA hydrolase deficiency 227095 INTEGRATION OF PROVIRUS%REACTOME%R-HSA-162592.5 Integration of provirus 23825 268373 319583 22596 14375 16646 15361 101739 108138 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.4 Defective pro-SFTPB causes SMDP1 and RDS 20388 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190373.6 FGFR1c ligand binding and activation 21814 80857 67903 14180 14177 64654 14175 14173 14164 INWARDLY RECTIFYING K+ CHANNELS%REACTOME%R-HSA-1296065.4 Inwardly rectifying K+ channels 242425 14702 14696 16514 16519 16520 54393 14697 16518 16516 14710 14699 66066 14700 16523 20927 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 20928 14693 16517 64337 14709 14701 56379 211480 PTK6 EXPRESSION%REACTOME%R-HSA-8849473.2 PTK6 Expression 20459 14815 75273 15251 13819 RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.5 Ribosomal scanning and start codon recognition 16785 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 100039316 20115 76846 100040298 13665 67204 267019 26905 67941 57294 75705 27207 67097 670832 13684 633683 20044 27050 208643 667279 20085 668144 20084 217869 382492 20055 75617 27370 629957 20102 20103 668668 667739 66481 225058 100038875 SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 96%5654741 Signaling by FGFR3 14172 80857 14180 12402 24064 64654 17346 14175 14173 14164 109880 667035 22190 19247 26413 26417 327826 14425 18176 14388 20662 15461 19052 107971 19053 51792 18803 80903 18708 18706 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME%R-HSA-389887.5 Beta-oxidation of pristanoyl-CoA 80911 15488 12908 17117 170789 74114 93732 74121 DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 96%9656255 Defective OGG1 Substrate Binding 18294 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-3560782.5 Diseases associated with glycosaminoglycan metabolism 18295 12111 121021 14043 13004 14042 15530 14595 13521 17022 72136 103978 269941 218271 14264 14733 53374 15529 11603 23888 16545 20971 20969 14734 116847 117592 71951 20970 29873 13003 56773 14735 23972 72727 15212 15211 27047 12032 13179 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.12 RAF MAP kinase cascade 16451 208884 18039 18183 14810 83961 11472 100042150 20779 23859 14814 17295 109880 216148 26413 26417 14360 29857 12988 20416 327826 109905 20418 13649 19730 21802 54401 26395 194231 26396 54519 29875 18176 245684 20662 22371 16416 15461 75590 110157 231474 23980 18218 14161 63953 21894 13537 215449 19252 11836 240672 109689 216869 26403 72399 18708 18673 18709 16452 110135 99571 18706 22330 16706 74769 14587 14586 19197 14588 19262 545987 640703 19419 83409 240168 15234 18188 18596 11876 56438 18582 56327 16184 16183 19713 19060 13385 18595 70686 53310 13383 16453 19046 13866 110606 26554 226525 14272 18015 320484 211255 240057 101809 54153 114715 114716 19414 69601 19415 14083 218397 114713 16188 16185 12984 12982 16192 16191 20739 20740 640524 20742 20741 20743 12322 12323 108058 12325 16186 14255 17967 80297 320139 56705 19047 73699 19052 19053 51792 226849 225849 26931 14573 21770 26932 12223 19417 19418 71920 13874 15200 211323 14585 18777 21762 22123 14812 19179 19181 19182 70178 23996 226016 19184 107971 19671 436004 26440 216169 16653 19166 11839 19167 13645 12981 26441 12048 80903 384783 26442 69077 14186 66997 14165 23997 56436 16367 17463 14172 57296 80857 20422 26445 14170 26446 19172 14180 19173 14178 19175 14177 67112 19177 64654 14175 14174 26443 14173 26444 14164 83379 19170 66413 667035 22190 59029 67089 70247 57295 16399 14268 235584 67603 319520 19731 18611 18591 70727 21687 11600 19732 17532 76089 171463 56392 67836 71746 14256 18761 233046 17169 57437 16590 19092 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%8868766 rRNA processing in the mitochondrion 68626 72181 52575 75619 227682 83485 94254 224481 66132 66410 67390 217038 15108 69821 71989 101122 68017 PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%5357801 Programmed Cell Death 74568 12387 12550 211586 22628 13176 13555 20230 21781 11651 11652 74268 227753 72565 66593 26413 26417 15519 16211 54401 55948 12015 12371 19877 12369 68097 14453 11518 13169 18810 21981 22352 16362 56702 50709 14957 18107 50708 14958 17087 80838 12539 209456 72993 56455 13144 13368 69635 13347 13143 97165 107449 94275 107448 56369 22062 21898 12578 26419 21762 22123 19058 19179 19181 19182 23996 19184 26440 19166 12043 16906 19167 22627 26441 12048 26442 11789 69077 12125 66997 23997 14103 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21873 13511 26443 13510 26444 21872 27061 12367 19170 18772 109620 13512 66413 667035 22190 59029 67089 70247 269582 100039786 12261 18753 22059 66371 14939 14102 68953 16176 75608 12362 12368 14251 18571 12363 22195 22035 224105 50873 16396 208092 12370 66700 19766 11797 56532 670717 14252 16173 22030 108155 16363 56424 12475 21933 16646 67245 69146 225471 11796 106759 11798 12018 50701 22061 53378 105513 16175 12028 54722 434174 12122 71609 14082 18761 70415 74143 78514 223255 19057 56215 171543 74006 67013 14272 22631 22629 12169 14083 20848 11783 23797 20740 PKR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9833482 PKR-mediated signaling 12534 17973 20892 100038882 16150 23992 21357 16151 18148 193740 23806 19255 19106 100037258 73699 66369 22059 67781 22196 19052 19053 56417 51792 20698 13665 67204 26905 15512 226849 15482 56791 67513 67030 16201 26399 101831 104806 20617 71885 13211 14087 100040608 15481 237211 72775 14088 60534 12675 20846 228607 217069 20848 69928 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 96%210993 Tie2 Signaling 13449 11600 74769 11601 50915 11602 18176 20662 15461 14786 18708 19247 18709 18706 20416 21687 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%352238 Breakdown of the nuclear lamina 12368 16906 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 96%189085 Digestion of dietary carbohydrate 232714 81600 71884 11722 226413 100043686 58866 69983 C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME%R-HSA-5621481.3 C-type lectin receptors (CLRs) 53859 353328 66824 229709 14360 16438 16439 18747 16440 17096 18176 15461 110157 18479 18607 328572 18481 12914 640703 19055 19056 18018 18019 21762 22123 19058 12675 108723 18021 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19698 19177 15896 21402 73086 16150 170786 26443 26444 16151 19170 12042 66413 26965 667035 22190 240354 59029 26409 67089 103583 70247 14127 18753 16176 224105 12370 234779 18034 20963 100041766 216150 66513 93765 66589 22034 66724 68652 56619 269328 332579 26888 56644 22200 381809 17312 56620 17474 22192 17829 18749 100039649 140474 224116 216080 17063 73732 GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.4 GTP hydrolysis and joining of the 60S ribosomal subunit 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 75705 13684 208643 217869 226982 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 13665 67204 26905 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 PRE-NOTCH PROCESSING IN GOLGI%REACTOME%R-HSA-1912420.4 Pre-NOTCH Processing in Golgi 11937 11938 20338 14595 53313 54613 18129 18131 18128 18132 16848 18550 19719 20443 17305 19346 100042343 BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME%R-HSA-77346.5 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 15107 97212 231086 11364 26922 93747 GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME%R-HSA-159740.5 Gamma-carboxylation of protein precursors 56316 19128 14058 14071 19123 14068 66901 14456 14061 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665230 Drug resistance in ERBB2 KD mutants 13866 59079 12539 15519 THE NLRP3 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844456 The NLRP3 inflammasome 54483 15368 66824 216799 19697 18034 12362 18033 18439 22166 67955 19200 56338 55991 11820 15516 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME%R-HSA-399955.4 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion 18717 227377 14159 18845 18186 18844 19353 18846 20130 21894 223881 243743 20346 14360 DEFECTIVE TRANSPORT OF AMINO ACIDS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME%R-HSA-5659735.5 Defective transport of amino acids by SLC6A19 causes Hartnup disorder (HND) 74338 IMPAIRED BRCA2 BINDING TO SEM1 (DSS1)%REACTOME%R-HSA-9763198.2 Impaired BRCA2 binding to SEM1 (DSS1) 12190 20422 M-DECAY: DEGRADATION OF MATERNAL MRNAS BY MATERNALLY STORED FACTORS%REACTOME DATABASE ID RELEASE 96%9820841 M-decay: degradation of maternal mRNAs by maternally stored factors 78893 69125 18983 13682 13681 52846 192119 231464 58184 75705 13684 208643 234594 218693 56057 12193 382035 53621 72068 232791 104625 228140 192170 239528 18458 CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.5 CaMK IV-mediated phosphorylation of CREB 207565 100039592 12322 640703 12323 108058 12326 12325 55984 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 96%9010553 Regulation of expression of SLITs and ROBOs 622534 13138 238217 14852 16785 666669 16870 100040021 16871 67025 100043391 268902 326622 668182 241053 16876 432502 19989 76808 19899 100043184 19921 19934 100043755 16872 67031 319195 100043209 20562 68193 15399 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 68092 433702 192160 208643 67923 21762 22123 60365 19179 19181 19182 23996 19184 68134 26440 19166 19167 26441 192170 26442 19826 69077 66997 23997 66441 56436 17149 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70247 12830 19876 20563 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 268721 668668 667739 14853 16825 16392 672214 170822 66481 225058 71745 100038875 100038991 68028 225363 100043000 67891 17690 100043295 18458 INTERLEUKIN-33 SIGNALING%REACTOME DATABASE ID RELEASE 96%9014843 Interleukin-33 signaling 77125 17082 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME DATABASE ID RELEASE 96%380095 Tachykinin receptors bind tachykinins 21337 21333 21334 21336 21338 ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8964540 Alanine metabolism 76282 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8931987 RUNX1 regulates estrogen receptor mediated transcription 12400 13982 12005 71393 14732 INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME DATABASE ID RELEASE 96%400508 Incretin synthesis, secretion, and inactivation 18508 66624 12387 14695 14526 21416 233081 66286 56529 18548 64337 14607 14463 16392 16846 12591 225642 236781 76687 13482 107221 69019 242851 14688 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.4 Peptide chain elongation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 13629 68028 100043000 67891 100043295 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9679514 SARS-CoV-1 Genome Replication and Transcription 13207 22346 19645 67197 FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 96%77042 Formation of editosomes by ADAR proteins 56417 110532 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 96%173599 Formation of the active cofactor, UDP-glucuronate 22235 242585 70484 216558 67883 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 96%9022702 MECP2 regulates transcription of neuronal ligands 13388 12918 433759 12064 20604 20466 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 18011 232232 13388 16449 240055 225164 20602 11487 54485 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 15213 56233 17869 15214 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 15205 19664 433759 15182 SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.5 Signaling by MRAS-complex mutants 110157 17532 109880 19047 19046 11836 56392 54401 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.4 Thrombin signalling through proteinase activated receptors (PARs) 14702 14696 14675 14064 14062 14061 14697 14710 14699 14065 66066 26413 14700 26417 14688 14708 14673 14672 14706 14704 14695 14674 14676 14693 64337 14709 14682 14701 109689 216869 SARS-COV-2 INFECTION%REACTOME%R-HSA-9694516.9 SARS-CoV-2 Infection 71164 53618 16451 20448 56208 227619 66383 19089 67443 13200 208884 78610 22628 11651 12389 11652 269523 54401 55948 233870 378425 218978 218035 15516 18607 66357 269338 16172 18550 22365 80743 12914 28185 71586 230073 66641 71956 228607 12695 217069 224912 20817 56217 20815 77573 14609 22627 24088 21897 93687 257630 56480 54131 66397 171095 15006 69608 218811 99683 240095 667803 23881 27041 14991 77371 100039786 20334 20390 66371 68953 75608 12785 228545 170762 108989 231042 227699 208092 223921 227720 66700 269113 67197 66679 18141 107939 69482 71805 73158 54563 71732 19069 70699 72787 18226 218210 54721 105513 233405 20847 27207 15975 67097 670832 633683 13207 16171 20044 27050 667279 20085 668144 20084 382492 20055 75617 27370 629957 20102 20103 668668 667739 66481 225058 100038875 16785 216799 18186 19645 100038882 12330 15519 15529 100039316 23888 20971 100039592 19386 20969 20115 76846 100040298 71951 20970 14735 267019 445007 67941 57294 15530 50528 70008 171283 103978 14733 69912 103468 15977 14734 234865 12675 59015 69736 110379 75669 225326 107686 384091 666609 216766 16150 621705 21872 20595 16151 66603 53975 192656 276919 20641 16179 667035 20638 225913 22190 69731 432803 26409 67332 257632 11603 107607 101772 108960 22196 102566 404545 170743 15007 12010 170744 105722 382014 17195 320091 22031 56489 233246 20014 72512 54123 103963 243634 56637 69038 66513 93765 13135 66589 19247 22034 66724 68652 15170 15469 22631 103534 67075 57377 22629 27801 228136 20846 75965 70546 108687 14423 269181 214424 57437 328417 217664 606496 69035 67287 107895 80285 20446 52552 20444 671535 22346 20442 547253 80286 20443 17308 17158 68292 20440 23797 67569 16430 14376 20447 REGULATION OF CDH11 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9762293 Regulation of CDH11 gene transcription 59058 24136 15426 16201 56198 20683 20613 15227 77630 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME%R-HSA-8863795.3 Downregulation of ERBB2 signaling 59079 12539 56424 18183 83961 100042150 84092 12223 11651 13874 11652 15200 211323 19248 667035 22190 19253 67588 15519 13866 13649 75717 17179 13645 23797 GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 96%3229121 Glycogen storage diseases 14377 14385 13853 68401 667035 105193 22190 232493 14936 74185 27357 14387 53412 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 96%166187 Mitochondrial Uncoupling 22229 22228 20523 74011 11739 22227 212933 BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME%R-HSA-3858494.5 Beta-catenin independent WNT signaling 233833 18796 18797 14686 21415 18795 14681 12387 16842 18643 12322 16438 93840 16439 16440 20187 105782 66313 216869 106042 21414 21416 208846 19354 74325 640703 19055 19056 18018 21762 22123 19058 19179 19181 19182 23996 19184 75788 18752 26440 19166 19167 26441 26442 69077 170758 66997 23997 56436 17463 57296 20422 11848 26445 26446 19172 19173 56513 19175 19177 57265 26443 26444 19170 14697 66413 667035 22190 18751 14710 59029 14699 26409 66066 67089 14700 70247 22411 14708 14706 14704 14695 14693 64337 14709 22417 14701 76850 239528 14702 14696 236511 14367 14365 14362 14366 19353 22418 11771 14370 213988 11772 71770 217351 214150 14368 14369 14688 22408 232910 17454 11773 13542 13544 13543 67300 26563 26564 12757 22419 225600 18750 19091 19092 18587 18588 18099 GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610785 GLI3 is processed to GLI3R by the proteasome 12234 93687 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 56637 667035 22190 59029 67089 70247 18747 21762 22123 14634 19179 18749 19181 19182 23996 19184 26440 19166 24069 19167 26441 26442 69077 66997 23997 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5619113.4 Defective SLC3A1 causes cystinuria (CSNU) 30962 20532 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654700 FRS-mediated FGFR2 signaling 327826 14172 80857 14180 14178 14177 67112 64654 14175 18176 14174 20662 14173 14164 15461 107971 80903 19247 14165 CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME DATABASE ID RELEASE 96%8955332 Carboxyterminal post-translational modifications of tubulin 74410 237930 238328 67534 74711 244071 101100 320244 625850 223723 271813 110012 66257 69737 226841 22152 76223 227613 319953 22153 22142 22146 67951 73710 100042651 545486 22147 22151 67269 330010 66648 69216 231093 70892 22143 102747 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660516 Synthesis of PIPs at the early endosome membrane 233315 225326 170749 67073 77116 103199 18711 268783 84095 18704 234729 101490 17772 269180 75669 234515 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME%R-HSA-5083627.3 Defective LARGE causes MDDGA6 and MDDGB6 108902 16795 FORMATION OF THE DYSTROPHIN-GLYCOPROTEIN COMPLEX (DGC)%REACTOME DATABASE ID RELEASE 96%9913351 Formation of the dystrophin-glycoprotein complex (DGC) 13138 15530 244431 13405 20650 13528 13527 20649 24051 20648 20391 24053 24052 16651 268534 20392 11603 22288 16775 16776 16777 16779 16780 226519 16782 16772 23928 16773 16774 13497 TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME%R-HSA-5250992.4 Toxicity of botulinum toxin type E (botE) 64176 64051 20614 CELL CYCLE, MITOTIC%REACTOME DATABASE ID RELEASE 96%69278 Cell Cycle, Mitotic 52717 99152 56299 668450 29870 17187 12534 217653 100038822 26413 12545 59046 244329 59021 382030 67121 56205 21664 52432 76044 78658 71175 74549 66352 67181 52683 70231 16452 15516 328572 109145 17216 272551 17215 17217 17218 17219 103573 17220 78833 12544 69270 16906 22627 63955 22390 99412 72568 77805 12530 231506 12531 629959 54124 12532 20459 75660 23834 71988 56438 18969 18968 19075 19076 66371 68953 75608 14235 208092 66700 19088 105513 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 21973 56371 27401 16881 12448 12577 12576 108911 73470 16563 75786 18747 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 59125 218914 59126 12235 217718 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 12428 57294 56455 226747 17120 26951 100710 108000 229841 12237 12617 107995 72415 83815 12615 66570 319152 244495 208628 76707 67139 68014 83431 13589 100043858 67849 12580 69912 625534 12579 13006 12578 18472 67733 103468 66468 76464 66442 67629 235661 56430 12427 234865 56150 12442 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 71521 13426 52504 17931 13424 228421 20843 15366 66671 17420 12572 15267 319168 319167 100986 319186 319178 319183 319182 319190 230376 319176 69654 71648 17274 319181 75296 56637 219072 225659 76478 22367 71955 78177 64383 224640 319169 319965 105988 28135 50850 214444 100042651 76816 54130 625328 78303 319188 15270 381644 18750 624153 23797 382522 20873 68121 232440 78887 78798 319149 22628 225745 231123 11651 11652 15077 74360 238799 18536 66296 214552 19646 18541 116733 13001 13000 100039026 17869 71909 237222 30939 17096 17997 13548 22171 21877 13361 18005 73738 68475 53598 208518 100088 236266 12009 99100 103733 22154 98386 74470 104318 101565 16328 259279 14211 83922 171567 51885 68298 19348 215387 26370 76789 72083 71819 70099 101706 233276 103768 74237 22147 22151 19650 19651 17865 27373 22143 268930 53857 22152 227613 72119 22153 22142 22146 67951 73710 13726 22145 22059 71782 545486 238463 170762 108989 231042 227699 223921 227720 380664 269113 66679 18141 23825 107939 69482 71805 16475 54563 19069 70699 67141 72787 64899 18226 218210 50793 18392 72590 18393 30949 66634 14245 77011 26428 19046 72486 26429 12537 56452 77744 64898 71978 20135 15519 11350 16211 19384 219103 229776 50496 13559 104394 21762 22123 19179 19181 19182 67956 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 27214 17463 67177 57296 20422 26445 14156 26446 57441 19172 70024 19173 19175 19177 21402 26443 26444 19170 66413 26965 667035 22190 18751 59029 67089 103583 70247 22196 671392 69745 327762 59001 19687 19718 69263 231863 66979 18538 19324 381306 68275 106344 72151 18971 68240 18972 19891 18973 18974 74498 67967 20878 217232 56317 59008 18817 66156 433759 216080 56041 69957 448987 17222 75430 68612 52563 22194 76308 68999 52206 100039535 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.6 Formation of the cornified envelope 76770 19143 72432 12333 67451 259277 16769 74176 19041 68668 76560 16939 20754 240633 13511 56460 13510 626834 18772 109620 18550 13512 18553 64058 227937 20765 70166 13706 12336 66203 317653 71529 69511 21816 20129 668304 66344 13507 16480 13506 13505 386463 99681 14027 12365 REGULATION OF CDH1 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764265 Regulation of CDH1 Expression and Function 233833 12388 232440 19089 12387 13200 13626 11735 12550 319149 20586 19645 20779 13858 15077 104836 13345 12330 20901 21417 60611 52615 16601 114142 19646 26413 26417 21418 13001 13000 100039026 17869 245688 18109 22160 16480 22330 16600 66357 53325 17246 66286 228839 18550 18553 69019 93759 93760 13430 21762 56529 22123 19179 19181 19182 67956 23996 19184 105837 26440 13017 19166 13016 19167 15220 26441 26442 69077 66997 23997 56436 17463 57296 20422 24136 26445 26446 20683 19172 19173 19175 15376 19177 26443 26444 22431 21423 19170 14694 75339 66413 192173 667035 22190 59029 18746 67089 76007 56805 21406 70247 21885 18554 15267 319168 319167 13040 13030 76850 239528 319186 12385 319178 319183 319182 66624 236511 20613 319190 330914 319176 319181 20014 213988 103963 217351 214150 69038 13135 99982 76687 228913 20583 14056 18717 17454 319169 57377 625328 78303 319188 15270 433759 217734 99011 15182 624153 16430 14376 382522 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME%R-HSA-5619507.5 Activation of HOX genes during differentiation 22632 18508 232440 13626 319149 15077 66310 140858 66420 69833 67710 52615 15399 245841 69920 19646 20022 213464 20020 20181 231329 20021 69241 17749 245688 100043714 55982 23808 19401 15267 319168 104625 319167 13654 319186 22658 328572 319178 319183 319182 17268 15400 17344 319190 16475 231051 15412 16658 18514 15407 67278 15401 13018 319176 15423 329559 319181 15410 103889 18771 15436 15434 15394 15429 58184 15183 20185 17979 218772 19411 12914 56406 14056 319169 22289 625328 16476 78303 319188 15270 624153 381022 382522 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%9609507 Protein localization 16922 71382 12908 66865 17117 66105 67528 13142 74114 110959 70503 18126 11430 228061 22333 224824 18634 15112 28200 56185 80911 71767 76263 13850 73078 12012 15925 111175 19193 93732 20280 51798 74043 171210 11611 212503 17527 65098 56794 19298 18416 15368 22284 11692 28146 30960 69617 103172 66826 27643 19122 19301 66531 66525 52815 56322 18632 433806 20524 100042179 66437 12328 17714 66433 66169 15929 56273 28185 100043869 67105 668173 21855 103737 18633 72129 30059 19302 71446 14356 30055 224727 68185 59038 56495 11429 74147 53333 171282 68033 11666 67604 26458 12856 15488 30057 113868 21856 170789 30056 26378 66119 15356 22318 100039174 14545 30058 66887 20907 66170 11820 223696 12974 52551 72170 17713 67713 67979 67892 636544 67264 74159 14297 667035 22190 19299 66821 100900 66445 56535 26874 13726 15510 12359 56389 11739 11740 100041766 100043039 17827 66212 68653 83762 71883 11947 66075 14712 11946 15526 15926 53375 100041835 216080 78830 50799 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME%R-HSA-5620912.4 Anchoring of the basal body to the plasma membrane 20873 68121 12534 78887 22628 277939 225745 231123 654470 227613 67590 74360 22153 18536 22142 66296 214552 74201 18541 75786 15519 18747 67161 53869 71909 140810 237222 22145 17997 67978 18005 73738 68475 51792 53598 208518 380718 236266 100986 244585 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 77048 230376 260305 69654 52906 17274 83922 18000 216363 75296 26370 72140 76707 219072 13589 225659 18472 53885 76478 320299 329795 78177 27078 28135 214444 76816 217335 54130 232987 18817 381644 13427 22627 109242 13424 382090 232944 231214 27373 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME%R-HSA-5655799.4 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) 53945 15203 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME%R-HSA-5579011.4 Defective CYP2U1 causes SPG56 71519 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME%R-HSA-2173795.6 Downregulation of SMAD2 3:SMAD4 transcriptional activity 20602 22284 228839 83814 11545 66105 97064 667035 22190 93836 26413 20185 26417 67821 20482 20481 19042 94093 17126 17127 17128 66313 433759 216080 17131 21815 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.4 Mitotic Metaphase Anaphase Transition 18817 67141 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME DATABASE ID RELEASE 96%381038 XBP1(S) activates chaperone genes 225849 320209 56494 16905 22393 12282 15191 52639 72599 13191 192193 74322 71765 22642 28106 28146 231997 12751 56219 228998 67398 54616 52808 11370 58193 105785 11972 66515 20416 69162 100037258 74126 14583 11518 606496 21894 71853 20818 107513 67838 68090 381801 27362 50907 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME%R-HSA-5657655.3 MGMT-mediated DNA damage reversal 17314 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%166662 Lectin pathway of complement activation 14134 17195 71693 239447 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.5 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus 19128 14058 14071 19123 14068 66901 14456 14061 MAPK1 (ERK2) ACTIVATION%REACTOME%R-HSA-112411.3 MAPK1 (ERK2) activation 16193 54721 16451 16194 26396 19247 16452 26413 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.4 Ceramide signalling 18053 18049 20598 DEFECTIVE MTRR CAUSES HMAE%REACTOME DATABASE ID RELEASE 96%3359467 Defective MTRR causes HMAE 210009 238505 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 96%425561 Sodium Calcium exchangers 238384 317750 640703 20541 94249 170756 76376 110893 214111 110891 109552 BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME%R-HSA-70895.10 Branched-chain amino acid catabolism 78038 243382 227095 11992 229517 72039 66885 56357 12035 12036 66948 107146 58875 104776 110446 12908 12040 12041 13171 13382 12039 15108 93747 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME%R-HSA-418592.5 ADP signalling through P2Y purinoceptor 1 18441 14708 14672 14706 14702 14704 14696 14695 14676 14675 18783 14693 64337 14709 14697 14682 14701 26416 14710 14699 66066 14700 14688 KERATAN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022854 Keratan sulfate biosynthesis 18295 72297 14595 17022 56336 56386 108902 14264 70484 53374 16545 227327 231727 53625 54613 116847 57370 53418 56375 76969 54371 56773 20444 20442 20443 27047 METABOLISM OF SEROTONIN%REACTOME DATABASE ID RELEASE 96%380612 Metabolism of serotonin 17161 11669 SELECTIVE AUTOPHAGY%REACTOME%R-HSA-9663891.5 Selective autophagy 22241 56480 67443 21821 67526 11793 100756 68146 66734 72018 269523 17966 19305 66105 245860 667035 22190 22334 22333 18541 15499 22335 15519 13001 13000 234663 100039026 12638 11520 26369 68097 57320 22195 108099 50873 56455 241113 71648 11920 18412 15185 100041766 66905 66410 93765 66589 13819 15481 66169 28185 100043869 235661 108079 19079 53333 108097 66119 13427 67414 19082 13426 170731 223696 13424 68943 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME DATABASE ID RELEASE 96%597592 Post-translational protein modification 270160 17342 56208 19823 22201 19328 22209 12663 53323 70620 330369 66853 140499 50788 22213 67128 12640 22214 101206 67615 268470 230903 66772 208372 76454 15925 65247 65255 84585 15381 142687 78910 109331 231380 65256 12848 70392 216233 12700 225055 232539 100043806 26891 231670 56444 67665 69754 22428 77113 12344 207952 59288 320118 30843 18550 68854 76294 21812 21813 72323 399566 214931 28185 68441 13016 11789 66397 69608 218811 99683 192156 56453 77371 20334 13436 13435 13433 217365 15387 22195 50873 19766 11797 22230 22030 108155 18970 11796 14827 73582 68137 99375 22210 72584 58186 13194 67561 67711 76843 66341 26885 109113 223701 100040573 67241 66647 67872 65973 216799 67040 320213 20230 56459 72607 50995 68031 55989 73162 68501 19720 226026 21951 17190 74493 75826 223870 224903 21973 21974 21969 12418 29817 12151 17248 19763 14799 12428 17246 54383 13619 241915 12416 75221 68350 19821 224111 12578 16193 12427 18195 30951 11839 13629 11487 192656 24110 257632 12266 625018 107607 231130 76768 59025 26374 69654 17274 11843 103534 57377 100042651 54130 108687 19341 269181 66940 208659 217664 77407 13602 19337 16007 107895 20446 16011 20444 16010 20442 246228 20443 235442 13801 17308 12653 17158 11698 20440 20254 67569 19338 56047 14376 19672 20447 94111 13406 53618 30060 20448 15464 227619 11704 19089 71421 19326 217847 107338 77583 105348 80752 16852 18220 15160 20856 66848 338366 83554 11576 66557 98170 17182 16425 232146 12155 76453 74761 12419 21849 53869 21802 74126 67731 100683 218214 21825 53598 214669 104318 101565 12702 14462 26370 15258 14534 66967 223455 66597 108123 320011 108124 23802 22644 66435 76332 75841 16834 270192 319642 102339 19346 338337 216848 17957 67542 56382 69834 97484 233824 12662 18148 53376 19211 18619 22658 17283 16866 13207 12343 12345 18519 12340 21857 20739 268977 20740 22632 20750 14479 11733 11735 18854 640524 56207 20742 20741 84092 20743 110616 11816 66105 80297 17125 17126 17127 17128 66313 19339 17131 22284 56456 22224 56505 225280 242362 26893 56249 69714 227195 109275 26894 68142 108679 233875 70020 19358 19359 235134 22591 107986 26572 21762 432940 22123 26895 19179 19181 19182 23996 19184 19671 436004 26440 19166 18035 19167 26441 26442 69077 66997 23997 69260 12234 56436 17463 57296 20422 26445 16334 26446 223499 19172 19173 19175 19697 19177 21402 26443 26444 16151 19170 12042 66413 26965 667035 22190 59029 26409 67089 68251 103583 20184 70247 269582 22260 20181 70681 22337 70238 19013 27223 56469 19365 13982 22025 107976 19883 210766 11835 18227 14815 59004 20610 208727 19016 22196 71974 100043429 621893 110784 26423 319162 19401 319173 229615 319163 21834 18667 22027 12021 235505 56187 12321 54601 19352 22427 20255 19090 16009 16006 12189 80718 104009 70945 67091 18538 20703 11625 66226 19324 12144 105522 243819 68275 14067 69162 14275 12793 67857 100042773 233826 20333 252870 215474 207352 74498 212712 66682 52036 76983 13032 245828 20878 12794 20466 240667 67727 214895 59005 14069 78232 216080 56041 75396 333883 21787 27096 67269 68612 72978 11804 330010 227648 66648 15182 22194 76308 69216 71393 76510 231093 100042343 70892 100039535 50907 110962 102747 193813 15161 74410 12068 75302 237930 317717 68837 238328 12534 56494 22223 67534 60409 50933 74711 89867 17425 244071 20602 235416 71599 101100 216131 228790 320244 67231 625850 66890 223723 56324 271813 110012 15239 66257 69737 226841 20844 76223 319953 12005 240087 59021 224139 56233 21420 21419 14161 207958 71853 109689 216869 99571 328572 22393 11806 13191 192193 17977 238055 19017 17978 105785 18024 268903 12914 18002 100043869 640703 12870 22041 11820 99412 12530 71902 11555 56438 100756 13171 67295 19329 170711 330908 80883 212518 54644 72434 97884 14276 70527 380959 110826 224624 74270 76630 71472 66124 69908 56447 104416 54161 83563 76338 225896 66889 21684 30941 74112 108138 246190 229603 216825 22258 414084 433931 226422 74256 329777 320772 21929 67196 109979 27392 109978 269295 14731 12836 11889 11890 59007 54198 70325 59042 12182 14232 68453 246103 69641 68468 100102 76877 58222 276846 239706 244682 56395 18453 18700 67292 320204 11647 110417 71897 66113 11650 18701 80294 18488 67556 17068 21683 11657 71003 11807 79464 68043 66913 67133 56748 14756 59040 26554 71954 239827 327942 55981 98388 211255 237847 21838 235106 19335 50797 19342 19336 70349 12847 70163 67843 67164 241062 68133 13003 215494 228366 19334 235323 320840 246179 272411 70574 231050 19331 78754 114654 333424 16588 210004 74996 12091 108760 217371 11881 71685 319651 26887 76942 14426 54160 108148 224836 171212 105450 232984 228812 12575 108105 64931 241391 360216 14595 207839 107260 233733 66111 15275 108150 170745 212996 74762 97440 54399 654821 18793 72077 217615 50935 271786 19332 14537 328778 67909 68311 108902 22217 68149 230801 68404 27401 207965 13163 74653 170707 235441 22334 26434 68947 22333 57783 73068 268890 22335 226418 15529 216395 75847 72585 234663 23934 242681 109359 217057 19386 109154 14422 53614 54613 213827 11799 327799 52276 11844 53334 22242 19340 20842 72096 68097 69363 16319 72084 70511 217364 67511 668145 20877 56358 72373 24061 76486 76800 234700 70675 56703 445007 19376 19357 53868 57256 232973 30940 56746 243853 140703 623661 12159 78928 56455 66459 171167 71665 67099 22225 19244 56336 320713 56386 70316 75985 107995 235504 68366 20585 69912 76246 108089 13006 214498 19325 225131 68328 56273 103468 66317 668173 103737 68365 72129 231727 19302 235661 235497 14734 66510 234865 22083 268281 109815 233900 320311 59015 54624 69736 57370 53418 56375 17069 110379 13427 19128 268510 13426 13424 14456 20843 17309 11891 227327 53625 21923 14148 15267 319168 14118 319167 382014 56737 319186 320438 208624 319178 102580 319183 24070 319182 208211 193670 381903 54197 13478 328370 319190 26754 22031 56489 319176 18034 216440 319181 20014 103963 69038 13135 13819 116870 67819 106021 20687 116891 15248 26927 20338 319169 67075 14423 78303 319188 80286 68292 16430 382522 13200 72297 381677 269523 24108 102323 54638 140858 12558 100737 73828 66199 56468 52615 230796 415115 80913 213464 27784 114893 54607 99311 71991 28199 74106 78309 17869 76863 245688 240263 66498 52245 98193 434130 17846 15251 320808 12638 79043 66200 14155 53417 76501 242418 57320 69456 59043 14154 12238 68842 12006 66398 75763 233805 234664 74251 66357 216185 67923 19123 71586 230073 71956 228607 217069 22147 19345 271457 19344 22151 106052 242960 30838 235339 22143 11848 30050 50762 11905 22152 227613 13010 22153 50754 22142 11461 22146 19349 17304 56418 67951 70361 71833 213980 66251 73710 68628 22059 50789 545486 30839 16709 170762 108989 231042 227699 223921 227720 269113 66679 18141 56389 107939 69482 71805 54563 19069 70699 72787 18226 218210 108153 23794 30806 108154 16795 210417 271127 229595 208936 77739 381694 269959 667279 14425 269328 230145 110119 100689 11842 69080 233744 331026 235130 29858 240322 54128 20357 11504 20356 17829 21803 18636 100039649 21826 667739 140474 224116 226866 217734 170822 17063 59048 71745 240913 100038875 223838 99011 225363 237360 330119 216725 73732 13138 66548 330267 207596 224697 56229 353328 239337 68273 77794 94192 12317 279028 11545 12330 14314 67311 665189 225742 236082 107652 26938 20451 19703 245847 227697 20445 19106 20449 100037258 54342 19025 50798 66174 57357 50877 56174 14583 13480 14584 234730 13481 22122 241230 75540 228368 66248 24060 240119 218138 20454 109785 52014 12764 20450 66789 57170 69064 94181 74091 68563 67422 20452 18010 241159 23956 216197 14061 26464 22361 18412 77125 11840 15481 385643 64138 108645 78920 72345 64654 14068 71952 66632 13495 102115 58911 63828 107817 22021 276770 271970 56316 14058 69082 14071 67902 66901 22022 69740 13494 194952 545260 117589 269955 78541 57295 69299 238024 11883 77035 233902 67014 67228 66521 105638 50760 99349 74008 16777 235320 77041 16779 242521 270086 209239 208691 226519 74492 330817 14268 67728 66799 116905 72194 15204 77038 69706 15007 217194 226541 65257 242785 69666 16912 19171 211949 107047 66537 233040 19185 231672 19192 73902 66998 56088 231863 67151 101358 53380 12449 66506 224023 16913 109161 228769 22193 103554 71538 19186 228998 19188 67455 100041766 14794 216150 217217 66513 71999 93765 269529 17155 83962 17156 230654 230815 22034 635668 66515 269514 78889 68431 230904 71865 380928 50868 207215 72433 22200 627648 75717 106572 67921 22192 67790 142688 243574 216344 67844 433759 74646 448987 22346 12977 319189 228003 19330 212919 20439 MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.6 Mitochondrial translation termination 64658 66419 64660 78523 94061 623346 102060 50529 100040519 68565 99045 66973 69163 52443 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 67681 108853 64655 211253 107733 320806 68537 17721 18100 17722 67707 17716 94066 17717 60441 17718 218506 17719 66230 17720 68463 67871 65111 74600 107734 66242 28028 68735 622268 27398 94067 67840 68836 79044 94065 57312 75398 68572 67308 64659 56282 66292 24030 66121 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 17711 17708 17709 17710 17705 EVASION BY RSV OF HOST INTERFERON RESPONSES%REACTOME%R-HSA-9833109.1 Evasion by RSV of host interferon responses 328572 12914 16451 19106 15977 54131 67923 71586 75717 230073 56438 228607 217069 54721 20847 667035 22190 15975 GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%1483206 Glycerophospholipid biosynthesis 114874 28169 68262 66659 18806 55979 225010 18778 14792 329502 66857 271844 67452 237625 66853 665270 270084 53357 67216 68255 232889 225845 13001 13000 100039026 104759 97212 231086 12038 12647 11423 66826 99712 236899 12651 237928 79196 56018 237542 212862 28042 12660 70568 13026 85031 76574 74182 106861 105501 18559 27281 18618 102278 67078 71760 74451 12891 75320 66461 68671 218121 226856 245532 320951 66586 668257 192654 74486 56305 116939 66727 266692 110911 100434 213603 242259 70129 68682 19210 27388 14732 18805 76768 18783 69923 23945 64899 18739 215456 74596 14245 19679 327958 52858 64898 13350 18807 99138 67800 14571 77582 67512 14712 18779 239759 26971 333433 108958 99010 210992 14555 26970 26565 215708 102247 18784 18782 78390 66350 231510 52123 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.3 Phase 4 - resting membrane potential 52150 16525 16530 16515 16526 16527 223604 16520 74571 16518 217826 16529 211480 210741 332396 241769 72258 16528 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.3 Sensing of DNA Double Strand Breaks 100039592 81601 19360 17535 27354 11920 INTRA-GOLGI TRAFFIC%REACTOME%R-HSA-6811438.2 Intra-Golgi traffic 270160 17957 56389 67542 56494 242406 228960 76877 97484 54399 233824 75985 11650 109181 22365 17155 17156 13047 230815 11840 56418 18195 108123 53334 108124 76332 16834 226089 53611 102339 19157 67474 19159 58244 17158 19158 72318 27277 338337 19338 73124 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME DATABASE ID RELEASE 96%73943 Reversal of alkylation damage by DNA dioxygenases 268420 69113 69090 75452 77987 231642 26383 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME%R-HSA-1250342.6 PI3K events in ERBB4 signaling 15200 211323 18183 83961 18708 100042150 12223 18706 13874 PDH COMPLEX SYNTHESIZES ACETYL-COA FROM PYR%REACTOME DATABASE ID RELEASE 96%9861559 PDH complex synthesizes acetyl-CoA from PYR 27402 18597 18598 13382 68263 235339 SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.5 Surfactant metabolism 18442 20390 20387 12945 224792 216197 52713 16541 14465 30937 70546 13036 27410 12984 12982 22130 20389 11551 20388 11541 11553 11540 20505 20531 MPS I - HURLER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206302.5 MPS I - Hurler syndrome (HS-GAG degradation) 15932 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.5 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects 12571 12567 12578 MATURATION OF REPLICASE PROTEINS%REACTOME%R-HSA-9694301.5 Maturation of replicase proteins 66383 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 96%9603798 Class I peroxisomal membrane protein import 67979 56273 103737 56535 72129 26874 18633 19302 74159 74043 59038 11666 19301 19298 14545 18632 20524 19299 66437 GAIN-OF-FUNCTION MRAS COMPLEXES ACTIVATE RAF SIGNALING%REACTOME%R-HSA-9726842.2 Gain-of-function MRAS complexes activate RAF signaling 110157 17532 109880 19047 19046 11836 56392 54401 DS-GAG BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2022923 DS-GAG biosynthesis 77590 12111 29873 212898 121021 13003 338362 13004 319901 12032 13179 72136 SCAVENGING OF HEME FROM PLASMA%REACTOME%R-HSA-2168880.3 Scavenging of heme from plasma 15129 93671 15122 16971 11806 11657 11699 15458 15439 16069 INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME DATABASE ID RELEASE 96%109606 Intrinsic Pathway for Apoptosis 211586 13555 22628 21781 11651 11652 12367 74268 72565 66593 26413 26417 100039786 12261 54401 55948 12015 22059 12371 14939 12369 68097 21981 18107 12370 670717 209456 56455 69146 11798 12018 22061 56369 22062 12028 54722 12122 19057 171543 12578 26419 22631 19058 22629 20848 11783 12043 22627 12048 12125 23797 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME%R-HSA-72737.4 Cap-dependent Translation Initiation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 75705 13685 13684 208643 217869 226982 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 13665 67204 108067 217715 26905 13667 209354 224045 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 18458 DENGUE VIRUS MODULATES APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9920951 Dengue virus modulates apoptosis 216965 56208 225326 109270 74370 56717 78757 18035 13163 227743 18036 56716 218978 66270 75669 19766 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811434 COPI-dependent Golgi-to-ER retrograde traffic 17957 26934 54160 74947 16570 107338 66111 240641 269152 16565 16564 16552 16580 16581 67023 16561 16562 72772 16558 70218 73470 20932 16563 75050 16554 286942 16568 71116 16578 319991 16572 66251 224630 16573 16560 56447 54161 213827 11844 73804 67511 77038 56358 59042 26951 16594 229841 668303 16579 232943 19348 228998 71819 68137 16593 105785 16551 110033 11843 209737 11840 74764 19324 66913 100042773 20333 11842 16569 50797 18195 108123 108124 70349 16571 12847 76308 228421 100042343 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.2 Interaction between L1 and Ankyrins 235281 20266 20265 11733 11735 640524 20742 20741 319504 20743 20271 399548 20272 20274 20273 110876 20269 72821 110880 269116 80297 20264 24046 16728 16536 110862 20739 20740 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.2 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 14609 RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380320 Recruitment of NuMA to mitotic centrosomes 20873 68121 12534 78887 22628 225745 231123 227613 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 259279 83922 171567 51885 75296 26370 76789 72083 101706 76707 233276 103768 74237 219072 13589 225659 18472 76478 78177 28135 214444 76816 54130 18817 381644 13427 22627 13424 27373 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.3 Tandem pore domain potassium channels 52150 74571 16525 217826 16530 16526 16527 332396 72258 223604 16528 HOMOLOGY DIRECTED REPAIR%REACTOME DATABASE ID RELEASE 96%5693538 Homology Directed Repair 70620 12566 11545 16881 240087 11350 50721 19822 12428 319152 11546 13870 12427 50505 20422 14156 667035 22190 107823 68251 20184 66131 269582 232314 70681 70238 27223 19365 56420 107976 210766 21853 59004 22196 100043429 15204 52864 19360 27015 69745 17535 21975 77782 19363 319186 19364 27354 319178 12021 319183 224008 319182 60530 81601 327762 269400 59001 319190 19361 22594 114714 16882 209334 22427 19687 19718 69263 15574 11920 319181 66979 12189 12190 235610 231724 237911 19355 57434 225182 74335 93765 26909 18538 235559 71711 12144 381306 68275 106344 72151 18971 68240 18972 233826 19891 18973 18974 80905 19367 19356 19362 67967 268465 12649 78303 319188 15270 382522 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.4 Propionyl-CoA catabolism 110821 66904 17850 73724 109136 DRUG-MEDIATED INHIBITION OF MET ACTIVATION%REACTOME%R-HSA-9734091.3 Drug-mediated inhibition of MET activation 15234 17295 MATURATION OF HRSV A PROTEINS%REACTOME DATABASE ID RELEASE 96%9828806 Maturation of hRSV A proteins 13001 16211 13000 100039026 66624 19047 66286 56529 19045 103573 18550 19046 76687 69019 PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.4 Phosphorylation of Emi1 107995 12534 18817 56371 67141 HIV ELONGATION ARREST AND RECOVERY%REACTOME%R-HSA-167287.5 HIV elongation arrest and recovery 20922 20833 68705 98053 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 20020 231329 12454 20021 69241 17749 100043714 58202 67923 27224 27632 20924 24116 12455 72949 13716 TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.3 TNFR1-mediated ceramide production 14694 21926 20598 21937 58994 18201 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME DATABASE ID RELEASE 96%8963693 Aspartate and asparagine metabolism 104816 14719 78830 14718 11484 50799 269642 73748 72560 27053 SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME%R-HSA-2173796.6 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription 328572 12843 20683 211586 17283 21781 228839 18550 16477 97064 667035 22190 107951 93836 26413 18787 26417 12579 22608 13559 12454 104394 51813 17869 17126 17127 12455 17128 72949 433759 17131 19650 21815 264064 MAPK3 (ERK1) ACTIVATION%REACTOME%R-HSA-110056.5 MAPK3 (ERK1) activation 16193 54721 16451 12534 26395 16194 19247 16452 26417 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 96%442982 Ras activation upon Ca2+ influx through NMDA receptor 640703 13385 18039 14810 53310 11472 13383 23859 19417 14812 18176 14814 19418 15461 12322 12323 108058 12325 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 12567 12578 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.5 Processive synthesis on the C-strand of the telomere 68275 18971 327762 68240 18972 14156 19891 22427 57321 67967 28113 101185 16881 21749 497652 21750 69745 18538 12144 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.5 VLDLR internalisation and degradation 22260 232910 11773 100102 22259 11771 11772 71770 67300 667035 22190 12757 218203 22359 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.2 Leishmania phagocytosis 17913 246256 17973 17909 105855 242687 330319 76884 22612 11308 22324 17886 108100 12928 11461 101314 26413 26417 14360 22325 11350 12502 57257 140579 17096 330662 11465 15162 140580 20430 17918 76709 19353 73178 20963 12229 56443 80987 68089 67771 11867 56378 66713 74117 245880 14191 14083 22376 215280 68524 50884 17925 83767 17882 329165 RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 96%9665233 Resistance of ERBB2 KD mutants to trastuzumab 13866 59079 12539 15519 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME%R-HSA-9018677.3 Biosynthesis of DHA-derived SPMs 16993 17001 15446 11684 13850 13106 11687 72303 13077 56448 13076 13114 19225 11689 14865 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 96%9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination 13138 20665 18992 18991 20586 17936 17937 97064 13121 20788 215798 15357 110789 17528 22288 19153 22601 17196 16777 18858 226519 16773 21676 13497 13654 15182 17136 SIGNALING BY ALK%REACTOME%R-HSA-201556.5 Signaling by ALK 328572 74769 16367 19283 11682 16453 16186 12142 15183 327826 15170 17869 13433 15251 620393 20466 18109 19242 20848 433759 18803 60533 17242 18708 15182 18709 18706 SIGNALING BY AMER1 MUTANTS%REACTOME%R-HSA-4839748.5 Signaling by AMER1 mutants 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.4 Autointegration results in viral DNA circles 23825 15361 101739 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%73854 RNA Polymerase I Promoter Clearance 216848 232440 319149 667501 107932 21429 20019 15077 21340 17191 21339 21341 64424 22130 13871 75316 66420 70333 69833 66136 245841 20017 19646 234366 26417 14885 209357 66467 66671 17749 245688 100043714 17420 12572 13872 23894 14884 23942 17192 15267 319168 319167 229542 319186 319178 319183 319182 319190 319955 106298 110147 319176 21374 319181 116871 116870 20018 14534 20016 319169 18519 12417 625328 78303 319188 15270 433759 15182 624153 382522 CLEC7A (DECTIN-1) SIGNALING%REACTOME DATABASE ID RELEASE 96%5607764 CLEC7A (Dectin-1) signaling 12234 56436 53859 17463 57296 20422 26445 26446 66824 19172 19173 19175 19697 19698 19177 21402 16150 26443 26444 16151 19170 12042 66413 26965 667035 22190 240354 59029 26409 67089 229709 103583 16438 70247 16439 16440 18753 16176 12370 18607 234779 18034 20963 100041766 216150 66513 93765 66589 22034 66724 68652 640703 332579 19055 19056 56644 22200 18018 18019 21762 22123 19058 12675 108723 18021 19179 22192 19181 19182 23996 19184 18033 26440 19166 216080 18035 19167 26441 26442 69077 66997 23997 TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME DATABASE ID RELEASE 96%1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 13361 640703 19286 18127 20751 19092 11651 320415 15519 14528 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%9022692 Regulation of MECP2 expression and activity 233833 98386 20602 236511 12326 21372 15228 213988 81004 12322 12323 217351 108058 12325 214150 56310 15183 20185 15258 18747 640703 17454 20466 433759 20877 15182 76850 239528 15194 NOD1 2 SIGNALING PATHWAY%REACTOME%R-HSA-168638.5 NOD1 2 Signaling Pathway 26399 11796 16150 16151 192656 16179 26416 66513 93765 66589 26409 22034 257632 29857 66724 68652 19094 107607 332579 26415 12371 12675 108960 12366 12362 74256 12363 21929 16396 12370 227290 11797 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020958 Interleukin-21 signaling 20850 20848 16451 60505 60504 16186 20849 20846 16453 20851 COBALAMIN (CBL) METABOLISM%REACTOME%R-HSA-9759218.2 Cobalamin (Cbl) metabolism 77697 109129 210009 67096 17850 109136 238505 SARS-COV-2 ACTIVATES MODULATES INNATE AND ADAPTIVE IMMUNE RESPONSES%REACTOME%R-HSA-9705671.5 SARS-CoV-2 activates modulates innate and adaptive immune responses 16451 56208 216799 100038882 15519 100039592 19386 378425 218978 15516 445007 16172 69912 12914 28185 103468 15977 234865 71586 230073 66641 12675 71956 228607 59015 217069 69736 110379 24088 21897 75669 257630 56480 54131 225326 66397 171095 16150 15006 69608 218811 16151 99683 192656 240095 667803 16179 23881 225913 26409 27041 14991 257632 77371 20334 107607 20390 108960 12785 170743 15007 170762 12010 108989 170744 231042 227699 223921 227720 269113 66679 18141 107939 17195 69482 71805 73158 54563 22031 56489 19069 70699 72787 18226 218210 54721 72512 54123 20847 66513 93765 66589 19247 22034 15975 66724 68652 16171 15170 20846 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.5 Synthesis of dolichyl-phosphate 227697 192156 67422 57357 52014 236082 57170 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-HSA-5607763.3 CLEC7A (Dectin-1) induces NFAT activation 640703 19055 19056 16440 18018 18019 19058 229709 16438 16439 18021 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296041.4 Activation of G protein gated Potassium channels 242425 14702 14696 16519 16520 54393 14697 16518 16516 14710 14699 66066 14700 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 14693 16517 64337 14709 14701 DNA REPLICATION PRE-INITIATION%REACTOME DATABASE ID RELEASE 96%69002 DNA Replication Pre-Initiation 52717 99152 668450 232440 319149 12566 15077 56371 12545 16211 17216 17215 17217 17218 17219 17220 12544 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 56436 27214 17463 67177 57296 23834 20422 26445 26446 57441 19172 70024 19173 19175 16650 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 18969 18968 19075 19076 15267 319168 319167 319186 319178 319183 319182 59001 319190 16646 319176 319181 66979 50793 18392 18393 66634 26428 26429 56452 68275 68240 19891 18973 319169 18974 217232 56317 625328 59008 78303 319188 66156 15270 216080 69957 17222 75430 68612 52563 624153 22194 68999 52206 100039535 382522 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.2 Signaling by activated point mutants of FGFR3 14172 80857 14180 14184 80903 64654 14175 14173 14164 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME%R-HSA-5368598.3 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 13543 68339 13542 13544 CELLULAR RESPONSES TO STIMULI%REACTOME%R-HSA-8953897.9 Cellular responses to stimuli 15901 67443 15516 13007 104069 56444 67665 22428 12344 59288 66508 545987 54170 52187 68576 66096 83409 74370 68441 268706 67605 245670 67838 270669 12282 20683 18044 18045 18046 17969 13058 13057 17970 17972 17764 56453 217365 213539 670717 22230 56445 19088 104110 16175 432530 210044 104111 224129 11512 11513 11514 11515 15526 18439 19085 216799 12322 12323 108058 12325 18747 110651 20112 12418 15364 665113 28113 77683 101185 15260 22166 29817 75560 56702 50709 14957 50708 14958 20657 12151 14630 26408 76408 17248 66401 17165 14780 19763 14778 80838 14775 66403 26462 12428 67305 17246 12460 54383 11833 13619 11911 110147 26399 11927 57321 20293 26400 69590 241915 76650 12416 17436 26398 75221 26420 50527 26414 14950 26397 17134 13875 27407 319152 75512 104248 68350 19821 18104 21749 11758 497652 14859 21750 11757 23939 140742 100043858 224111 12580 109778 216850 233016 12579 71389 12578 106766 16193 667310 23872 14629 23871 50932 26921 494448 15977 26419 12427 170644 12608 30951 11839 12043 18590 13645 12048 12562 18759 13665 67204 26905 15512 15482 16905 50758 69654 226641 101543 112407 112406 29806 319594 26570 54130 74126 50493 53598 18127 14776 12857 110323 12861 12862 12868 66142 12866 12865 100041785 333182 15510 19246 380975 17684 70640 17992 50490 14229 14228 12343 12345 12340 100043508 17387 64384 20750 17872 66105 12955 15499 72630 11350 56354 50497 17168 12017 216805 81489 101142 70356 230676 67669 27103 219158 270802 29810 98402 18415 268933 110920 56032 67384 72124 66538 16210 70369 71962 23950 216742 15525 319481 15505 231659 68196 101148 22791 277854 80888 252875 73442 70394 69065 12293 12295 12296 12297 12858 21762 13198 22123 12675 19179 19181 19182 23996 19184 18033 230784 26440 19166 18035 20463 19167 26441 26442 69077 66997 23997 12234 14381 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 15467 21402 107503 16150 26443 26444 16151 19170 66413 26965 667035 22190 59029 67089 70247 17708 20181 17709 17710 19013 13982 19883 11835 18753 14815 110784 16402 18667 19360 56338 17535 22027 12359 84682 27354 81601 18613 14783 11920 16006 12189 15185 11863 68275 67013 69162 68240 233826 19891 20466 217232 56317 59008 66156 216080 69957 17222 22339 75430 68612 52563 22194 68999 52206 100039535 50907 52717 99152 668450 56494 12387 20602 20867 26416 26413 26417 20416 19094 102626 16416 17164 11518 21894 71853 20818 107513 68090 78943 19014 77128 229003 26427 11865 208647 19377 381801 70804 27362 52466 22330 27053 328572 12915 15129 320209 17087 78284 15368 64209 15122 22393 12013 15191 21372 52639 109151 72599 11806 13191 56760 192193 17977 74322 238055 12611 19017 71765 18143 22642 103573 28106 17135 28146 17978 75766 59035 109333 231997 81004 12751 66993 56219 17260 67398 17261 12913 21898 52808 12753 242341 105785 18024 68775 268903 70461 15369 15183 20185 76252 93759 11972 217166 108664 74343 66290 12914 382056 56406 11909 640703 11964 26357 110935 11966 100039636 66335 11973 11974 74915 12334 338375 12336 20656 73834 56484 16476 114143 69543 66237 18477 21672 16542 16906 22627 27060 66144 20459 18128 56438 14697 13856 230099 54598 14710 14699 66066 14700 14708 14706 14704 14695 14693 64337 14709 14701 54409 11535 14702 14696 18453 81904 11657 14688 26554 208677 18749 15926 12575 211586 13555 19645 21781 12571 12567 12566 13557 12447 242705 56371 27401 12448 12034 12576 66592 27377 234663 19386 73699 68097 19052 51792 445007 225849 57294 56455 15530 54616 56551 58193 69912 103468 235661 234865 59015 69736 21351 110379 13427 14828 13426 13424 21881 17250 110208 11977 15267 66839 319168 64704 58233 319167 15502 14281 18181 74142 76850 319186 319178 319183 319182 236511 319190 56489 56717 319176 319181 213988 217351 56637 214150 227743 13819 14056 17454 319169 109270 108079 20846 20848 625328 78303 606496 319188 15270 14257 56716 624153 23797 382522 233833 232440 13626 319149 13666 19084 11651 11652 15077 269523 52615 19646 14360 11910 13001 13000 100039026 17869 245688 22601 15251 53417 78757 17752 228775 17748 17750 17751 18709 66362 109075 18706 66583 18607 27998 74769 72544 18707 50911 69639 72662 66446 227715 74108 67923 14609 14672 16412 22059 628438 14682 170762 108989 231042 227699 223921 227720 269113 66679 58226 18141 107939 69482 71805 16475 54563 19069 15361 70699 72787 18226 218210 11370 55991 27207 67097 670832 633683 20044 27050 667279 14080 20085 668144 20084 67186 382492 20055 75617 27370 71978 65019 12306 629957 16410 20102 14083 20103 668668 667739 672214 66481 225058 71745 100038875 100038991 68028 100043000 67891 100043295 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 12317 432502 19087 19989 76808 19899 100043184 19921 19934 100043755 193740 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 18442 100037258 100043876 100043893 100043423 100042986 20115 67281 14583 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 18412 15481 72345 63873 20821 228998 100041766 66515 20111 50868 22346 OTC VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956522 OTC variants cause OTC deficiency 18416 VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.3 Vif-mediated degradation of APOBEC3G 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70247 67923 21762 75717 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 ZYMOSTENOL BIOSYNTHESIS VIA LATHOSTEROL (KANDUTSCH-RUSSELL PATHWAY)%REACTOME%R-HSA-6807062.4 Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) 73166 15490 20787 13121 20788 74754 66234 18194 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.5 YAP1- and WWTR1 (TAZ)-stimulated gene expression 15257 22601 18519 21388 18091 21679 14463 21676 21678 97064 230899 14219 15258 21677 APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME DATABASE ID RELEASE 96%174178 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 52717 56436 99152 17463 668450 57296 20422 26445 26446 19172 19173 19175 19645 19177 26443 26444 19170 66413 56371 667035 27401 22190 59029 67089 70247 30939 20877 107995 21762 22123 20878 19179 19181 19182 217232 23996 56317 19184 59008 18817 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.8 Purine ribonucleoside monophosphate biosynthesis 67054 231327 14450 237823 100042069 108147 23917 229363 11564 11565 11566 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 96%8851680 Butyrophilin (BTN) family interactions 19041 547431 238555 237754 195349 170786 12231 22436 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 96%5610787 Hedgehog 'off' state 12234 93687 56436 17463 57296 81896 20422 26445 26446 19172 19173 19175 21821 19177 19087 21402 56438 19084 26443 26444 19170 19206 66413 26965 667035 22190 59029 67089 70247 16568 18747 213081 237222 380718 16396 106633 22158 244585 319757 70300 271639 240888 14632 380614 110350 19088 104110 73668 245866 67661 56637 432530 210044 104111 224129 11512 21762 11513 22123 11514 14634 18222 11515 14633 19179 18749 19181 19182 23996 74682 19184 26440 19166 19167 24069 26441 73916 26442 69077 66997 23997 19085 NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 96%168276 NS1 Mediated Effects on Host Pathways 18141 107939 74568 69482 71805 54563 16646 19069 100038882 70699 72787 18226 218210 69912 16211 103468 100039592 16648 19106 19386 234865 54196 59015 69736 54188 381686 110379 16649 170762 108989 231042 227699 223921 227720 445007 269113 66679 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 96%8942233 Intestinal infectious diseases 14917 170761 TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467348.4 Truncations of AMER1 destabilize the destruction complex 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 HIGH LAMINAR FLOW SHEAR STRESS ACTIVATES SIGNALING BY PIEZO1 AND PECAM1:CDH5:KDR IN ENDOTHELIAL CELLS%REACTOME DATABASE ID RELEASE 96%9856530 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells 12387 12562 19087 19084 11651 14697 54598 14710 63873 14699 66066 14700 14360 18747 14708 14706 14672 18442 14704 14695 14693 64337 14709 14682 78757 21894 14701 54409 18709 18706 22330 18607 74769 11535 18707 14702 18613 14696 18127 19088 56717 104110 109333 227743 432530 55991 210044 104111 14688 640703 224129 109270 11512 11513 11514 11515 12334 18749 12336 69543 17387 16542 14257 56716 19085 RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT%REACTOME%R-HSA-444411.5 Rhesus glycoproteins mediate ammonium transport 19743 58176 56315 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.4 B-WICH complex positively regulates rRNA expression 232440 319149 667501 20019 15077 21340 21339 21341 64424 75316 81898 66420 70333 69833 11461 66136 245841 20017 110052 17749 100043714 93762 22385 15267 319168 319167 319186 328572 319178 319183 319182 319190 319955 18432 319176 21374 319181 56200 56637 20018 14534 20016 319169 18519 625328 78303 319188 15270 624153 382522 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME%R-HSA-5579010.4 Defective CYP24A1 causes HCAI 13081 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.4 Transcriptional regulation of pluripotent stem cells 16600 18514 383491 332221 620395 83557 20674 17126 17128 14173 53417 20848 26423 18999 99377 22773 100038891 13835 15221 13819 58198 REGULATION OF NFE2L2 GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%9818749 Regulation of NFE2L2 gene expression 12914 328572 17869 18033 18024 19697 18128 17135 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 96%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 18011 13388 16449 240055 225164 11487 54485 11491 16450 18128 667035 76580 22190 DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.4 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) METABOLISM OF VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196854 Metabolism of vitamins and cofactors 11651 11816 665270 15519 15529 23888 20971 20969 77337 83702 21452 13361 71951 20970 14735 52466 14104 74450 68214 18127 73095 15530 71743 11806 75735 68087 211347 238055 67618 269614 106564 72621 66812 103978 73132 63857 18563 26464 55938 22361 18605 18606 11428 330064 209558 14733 19300 640703 79235 20525 170752 14734 68421 238505 210009 14873 18113 50500 78038 65107 72039 67861 17250 107476 22139 100705 239393 14276 22072 11603 110821 66904 17850 69060 109136 109791 19662 77697 109129 67096 19660 19659 100017 12182 108037 68453 67442 93835 59027 108156 17769 11433 16956 216225 65969 319945 71707 67375 17252 52710 246703 225994 105349 68591 107747 103711 69568 27973 20751 29807 71365 11807 17434 67426 11808 74080 99138 68646 320415 20527 110948 14528 78914 242642 66473 76889 69564 217707 268566 230027 105663 67914 11761 19286 230125 56075 102570 12850 223646 71883 16835 66454 227683 11813 54219 52064 11814 26363 100039707 192185 20509 69698 69372 69906 14725 214424 17768 15926 328417 54391 116914 16971 67287 80285 270685 52552 20425 109754 671535 67993 109672 547253 67795 54338 226518 20522 23959 216188 14603 19092 216134 67283 665563 12494 TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9703009 tamatinib-resistant FLT3 mutants 14255 CTNNB1 S45 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358751.4 CTNNB1 S45 mutants aren't phosphorylated 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO LRAT LOSS OF FUNCTION%REACTOME%R-HSA-9918442.1 Defective visual phototransduction due to LRAT loss of function 79235 19659 PYROPHOSPHATE HYDROLYSIS%REACTOME DATABASE ID RELEASE 96%71737 Pyrophosphate hydrolysis 67895 76429 74776 DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME DATABASE ID RELEASE 96%3296482 Defects in vitamin and cofactor metabolism 78038 93835 110821 66904 17850 72039 54219 109136 26363 68421 238505 65969 21452 77697 18563 210009 109129 67096 107476 14603 19300 110948 INFECTION WITH ENTEROBACTERIA%REACTOME%R-HSA-9640148.3 Infection with Enterobacteria 15129 55932 109637 15122 640703 17075 667035 100041766 12363 22190 236573 14469 LGI-ADAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%5682910 LGI-ADAM interactions 11488 56839 243914 246316 54377 23792 13385 213469 11496 12300 56216 54376 81905 20907 MIRO GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9715370 Miro GTPase Cycle 59040 67095 67414 70827 214952 229877 170731 TRAIL SIGNALING%REACTOME%R-HSA-75158.5 TRAIL signaling 14082 22035 21933 12633 12370 BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN EXPRESSION%REACTOME%R-HSA-1368108.9 BMAL1:CLOCK,NPAS2 activates circadian expression 11998 21372 109151 59027 17977 20893 14068 66277 272322 18143 12457 79362 17978 59035 81004 66993 12753 18787 12914 20181 56406 19013 19014 229003 11865 CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 96%5690714 CD22 mediated BCR regulation 15170 12518 17096 15985 12483 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.2 Regulation of localization of FOXO transcription factors 56484 100039786 54601 54401 56458 22628 22631 55948 23797 11651 11652 PHYSIOLOGICAL FACTORS%REACTOME DATABASE ID RELEASE 96%5578768 Physiological factors 104158 15257 18519 17380 21388 18091 18160 230103 53419 14463 18159 97064 230899 15258 REGULATION OF CDH19 EXPRESSION AND FUNCTION%REACTOME DATABASE ID RELEASE 96%9764302 Regulation of CDH19 Expression and Function 12385 20665 227485 12388 12387 230738 16480 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 96%75205 Dissolution of Fibrin Clot 94175 18788 12306 18815 18793 18816 20720 20194 20725 20719 18791 18792 18787 CASP5 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948011 CASP5 inflammasome assembly STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 96%211736 Stimulation of the cell death response by PAK-2p34 12367 224105 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME%R-HSA-1606322.3 ZBP1(DAI) mediated induction of type I IFNs 56532 56480 446099 69721 54131 207521 58203 19697 106759 71966 12675 16150 18034 16151 17874 18033 18035 13211 18036 142980 19766 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME DATABASE ID RELEASE 96%9636467 Blockage of phagosome acidification 108664 RAB REGULATION OF TRAFFICKING%REACTOME DATABASE ID RELEASE 96%9007101 Rab regulation of trafficking 270160 93739 70785 22241 235633 54189 192232 227800 60409 211922 66687 225870 67443 207592 329260 19326 216131 69440 70296 67231 19328 106039 12663 217449 11651 11652 53869 77980 19339 216363 64930 19325 68328 22084 68365 226089 270192 19345 271457 19344 319642 22627 19346 242406 56382 74018 12662 11891 19349 71648 17274 80718 66691 67091 66226 19324 75964 11845 270096 217835 14569 66975 14567 72433 227801 102442 66682 76954 106572 19347 229541 68449 245828 72121 381605 67790 67046 72825 100855 320714 19341 216344 56486 59005 67844 108995 74760 77407 319934 78232 245886 19337 320560 269589 329727 74105 320435 224617 27096 226407 260302 105841 235442 19330 233204 76308 74030 56715 76510 329877 103724 23797 209773 19338 192236 209815 DEFECTIVE VWF BINDING TO COLLAGEN TYPE I%REACTOME DATABASE ID RELEASE 96%9845622 Defective VWF binding to collagen type I 22371 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.5 Chaperonin-mediated protein folding 12469 12461 14466 12464 30050 50762 14675 53857 24012 24128 19739 22327 22152 227613 50782 14697 22153 12447 50754 216853 50779 22142 12448 11461 14710 22146 14699 14976 66066 67199 14700 18637 108077 67466 67951 27055 14708 13001 71833 14706 13000 14672 100039026 14447 213980 14704 73710 14695 68628 14676 22145 22059 14693 12465 16553 64337 55946 14709 50789 545486 238463 30839 14682 67134 14701 109054 56612 20698 99371 14702 14696 15183 14688 20848 12466 22147 21454 12462 22151 106052 66887 242960 12467 30838 12468 22143 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME%R-HSA-5579027.5 Defective CYP27B1 causes VDDR1B 244209 BASIGIN INTERACTIONS%REACTOME%R-HSA-210991.3 Basigin interactions 11931 11932 11933 53896 30962 12389 50934 83995 16400 16403 20737 66053 20540 330836 17254 268373 16412 57274 80879 20501 20539 26570 12215 16728 17136 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME DATABASE ID RELEASE 96%2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 80838 66403 170644 19645 22059 15361 15364 15260 104248 16906 75560 56702 50709 14957 50708 14958 FRS-MEDIATED FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654706 FRS-mediated FGFR3 signaling 327826 14172 80857 14180 64654 14175 18176 20662 14173 14164 15461 107971 80903 19247 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME%R-HSA-6782210.3 Gap-filling DNA repair synthesis and ligation in TC-NER 56438 667035 13871 16881 22190 66420 67439 69833 67710 245841 69920 20022 14885 66983 209357 71101 66467 71991 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 23894 14884 11834 27015 69745 59001 319955 22594 16882 19687 19718 69263 66979 56031 21399 18538 28000 68275 106344 72151 18971 68240 18972 252870 19891 18973 18974 67967 57905 99375 72584 13194 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME%R-HSA-388844.4 Receptor-type tyrosine-protein phosphatases 245446 19280 18213 272381 75409 386750 233977 19024 67533 19268 60367 239250 68507 327814 76965 245450 331461 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME%R-HSA-141424.4 Amplification of signal from the kinetochores 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 73804 19053 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 18817 110379 69928 13427 76499 13426 52504 13424 228421 ARACHIDONATE PRODUCTION FROM DAG%REACTOME DATABASE ID RELEASE 96%426048 Arachidonate production from DAG 231871 269060 23945 76192 66082 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME%R-HSA-389958.4 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding 12469 12461 12464 53857 22327 22152 227613 22153 22142 11461 22146 14976 67199 18637 67951 73710 22145 12465 545486 238463 12466 22147 109054 21454 56612 12462 22151 12467 12468 22143 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670095.3 Inhibition of DNA recombination at telomere 319178 319183 319182 232440 319190 22589 57321 319176 319181 319152 21749 66420 13163 497652 69833 21750 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 319169 28113 625328 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.4 SIRT1 negatively regulates rRNA expression 319178 319183 319182 232440 319190 319149 319176 21374 319181 15077 21340 21339 21341 75316 101867 93759 319169 625328 15267 78303 319188 319168 15270 20937 319167 624153 319186 382522 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME%R-HSA-209776.5 Metabolism of amine-derived hormones 21990 13371 13370 70337 12389 213696 114479 107585 22094 214593 99439 13166 18948 66811 21823 106200 13195 12640 22018 11298 216343 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9670439.2 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants 17096 22612 18176 20846 20662 20851 20848 20850 15461 18710 16590 16818 18708 18709 16452 14360 18706 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%438066 Unblocking of NMDA receptors, glutamate binding and activation 53623 640703 14799 14811 13385 18039 14810 53310 11472 14802 13383 23859 14812 14814 14813 12322 12323 108058 12325 14800 SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660514 Synthesis of PIPs at the Golgi membrane 234129 83493 225326 11842 67073 224020 107650 103199 18711 64436 320634 84095 18704 234729 75669 11840 18705 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.3 Defective factor XII causes hereditary angioedema 58992 16621 14061 CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME%R-HSA-420499.4 Class C 3 (Metabotropic glutamate pheromone receptors) 242425 387513 54393 387353 387515 353148 353165 387348 14823 387356 108073 268934 108069 108068 210198 83771 574417 14816 387347 57253 12374 108071 57254 110326 387355 83770 387342 387349 387512 387616 ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.4 Anti-inflammatory response favouring Leishmania parasite infection 13479 58861 246256 14131 11491 19087 19084 22612 217344 20620 14697 93671 16153 17886 26416 14710 14699 66066 14700 229709 14360 16438 16439 18747 14708 14706 14704 14695 16440 12502 14693 17096 64337 14709 14701 15162 14702 14696 19088 234779 19108 104110 20963 14678 18550 14677 14687 14679 432530 210044 104111 14688 16193 640703 70086 224129 11512 11513 11514 11515 14191 18749 14598 18803 319446 11541 23887 14129 242851 19085 NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 96%164939 Nef mediated downregulation of CD28 cell surface expression 12487 11773 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.8 Interleukin-3, Interleukin-5 and GM-CSF signaling 14389 74769 18707 21682 16451 12402 22612 16453 20851 22324 20850 20963 107746 18710 12929 12928 17060 16186 19247 16331 14360 16332 16184 20416 16183 18747 15170 22631 17096 20662 16188 16185 12984 12982 16192 16191 15162 12981 18708 18709 16452 18706 INTESTINAL HEXOSE ABSORPTION%REACTOME DATABASE ID RELEASE 96%8981373 Intestinal hexose absorption 20537 20526 56485 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME DATABASE ID RELEASE 96%2871809 FCERI mediated Ca+2 mobilization 16428 21682 234779 22324 20963 12229 229709 16438 16439 22165 22325 640703 19055 19056 16440 18018 18019 57257 19058 17096 18021 20662 17444 18803 16822 DEFECTIVE TRANSPORT OF NEUROTRANSMITTERS BY SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 96%5619044 Defective transport of neurotransmitters by SLC6A19 causes Hartnup disorder (HND) 74338 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-HSA-8850843.6 Phosphate bond hydrolysis by NTPDase proteins 72090 67464 12495 93685 12499 12496 12497 215446 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.3 WNT5:FZD7-mediated leishmania damping 19353 13543 71893 22418 16476 241275 13542 13057 26419 14369 237038 13544 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME DATABASE ID RELEASE 96%8939256 RUNX1 regulates transcription of genes involved in WNT signaling 12400 13982 12005 72780 20371 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME%R-HSA-6804760.3 Regulation of TP53 Activity through Methylation 17248 328572 50883 241764 17246 110147 22059 57748 11920 67956 77683 27374 667035 226830 22190 219022 BINDING AND ENTRY OF HIV VIRION%REACTOME%R-HSA-173107.5 Binding and entry of HIV virion 268373 12767 12774 12504 ACTIVATION OF SMO%REACTOME%R-HSA-5635838.2 Activation of SMO 68525 93687 16568 319757 59056 16147 74239 104346 230500 14451 57810 110355 117606 20423 19206 109689 216869 13363 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME%R-HSA-432030.2 Transport of glycerol from adipocytes to the liver by Aquaporins 11832 64008 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 96%9660821 ADORA2B mediated anti-inflammatory cytokines production 14702 14696 19088 19108 19087 19084 104110 14697 14678 14677 14687 14679 14710 432530 14699 210044 66066 104111 14700 14688 16193 18747 14708 14706 14704 14695 224129 11512 14693 11513 11514 64337 11515 14709 18749 14701 11541 242851 19085 CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 13388 16449 11487 54485 11491 16450 18128 INTERLEUKIN-2 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020558 Interleukin-2 signaling 20850 16185 20963 16451 16818 16186 19229 16184 16453 20851 20416 16183 MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.3 Microbial modulation of RIPK1-mediated regulated necrosis 56532 74568 12370 19766 RAC2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013404 RAC2 GTPase cycle 26934 110279 330177 18806 75409 105855 242687 216963 17969 20947 13511 70497 12389 11308 22324 22319 277360 192662 13058 18710 13057 19349 26431 17970 70584 101314 17972 66898 70361 71302 233103 22325 71544 229658 16412 13726 23943 75739 57257 29875 71782 94176 330662 94190 71703 52331 218581 84004 21917 56699 56491 109904 224105 238130 18708 18709 20430 18479 56419 70804 380664 18706 104445 13836 59079 223666 69922 223435 98386 330914 232906 71435 228359 23853 19354 66508 17827 68653 21844 208869 195727 210293 50884 71709 22042 329165 109934 WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.2 WNT mediated activation of DVL 13543 13001 13000 100039026 18719 13542 27373 13544 AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME DATABASE ID RELEASE 96%211163 AKT-mediated inactivation of FOXO1A 56458 23797 11651 11652 DENGUE VIRUS-HOST INTERACTIONS%REACTOME%R-HSA-9918481.1 Dengue Virus-Host Interactions 56208 69940 12387 319149 107338 15077 15381 18005 78757 19298 22352 70233 218978 19655 73075 15516 70616 269061 68598 67959 17087 17395 100040603 232989 107701 11806 67480 72047 68092 74326 67500 433702 75956 56031 80744 21898 66270 70225 68879 320632 67418 212880 66585 74351 83486 74370 71586 66877 23983 18521 228607 83701 217069 57905 68479 16834 15569 209416 20222 66899 60321 17713 66070 23845 66810 319322 19205 27967 76936 71702 68981 20639 229279 101943 81898 67439 94315 20646 192159 11993 53317 15382 53379 56258 59013 98758 11991 11834 15388 15387 18571 66055 68816 19766 54633 67465 69192 67285 236732 67958 68183 76479 20624 66642 20847 75062 77134 21349 27366 13205 28000 13204 76938 13207 233908 66125 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 74320 68188 54188 19899 12322 12323 108058 12325 13163 192292 15519 15529 216965 23888 20971 20969 54196 71951 20970 14735 14104 15530 14061 103978 14733 64340 622469 76246 225027 15481 67996 214498 22608 51796 66317 71713 233073 235497 14734 22083 20382 110809 20383 54624 21681 18035 108014 18036 192170 69207 19826 75669 100040029 225326 107686 384091 666609 21872 68705 20641 98053 20638 66420 69833 67710 245841 69920 67332 20022 20020 11603 231329 20021 69241 625018 17749 100043714 69116 22196 621893 15568 319162 15267 319173 319163 319168 22370 319167 319186 317677 319178 12759 319183 319182 17195 319190 12259 56489 56717 319176 319181 72512 13211 214763 227743 51810 319169 109270 78303 319188 319189 56716 382522 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME%R-HSA-5619061.3 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) 11416 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.3 RUNX3 regulates YAP1-mediated transcription 21679 21676 97064 21678 22601 12399 14219 21677 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 20201 20202 11909 26419 12675 16476 18033 18035 18036 24088 11820 21897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 21899 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 22030 12475 67245 18034 12229 434174 66513 93765 66589 22034 66724 68652 20111 12703 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME%R-HSA-418885.4 DCC mediated attractive signaling 19353 73178 330662 231148 226251 17973 223435 13176 20779 18208 14083 319713 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME%R-HSA-5619049.3 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) 12870 53945 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%391903 Eicosanoid ligand-binding receptors 574402 58861 16995 70086 19214 19222 14764 19217 19216 19220 19218 19219 57260 21390 CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME%R-HSA-9664424.3 Cell recruitment (pro-inflammatory response) 15368 16173 66824 216799 19697 69146 12495 12499 18034 12267 16175 19200 54483 12266 18438 16176 12362 18033 18439 22166 67955 56338 13035 23959 15516 STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.3 Striated Muscle Contraction 22004 11472 13405 22138 59069 11474 21925 21393 50876 21957 233199 21954 50875 17868 50874 13346 17883 21956 17888 109272 17885 17996 21924 22352 21916 21953 21952 21955 17901 17906 17897 17896 RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-HSA-73933.4 Resolution of Abasic Sites (AP sites) 18970 14156 59001 11792 22594 16882 19687 19718 69263 59047 66979 17193 71726 11545 382913 18294 72774 16881 18207 18538 11546 68275 106344 72151 18971 68240 18972 19891 18973 18974 268395 67967 69745 26430 100206 SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4615885 SUMOylation of DNA replication proteins 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 21973 21974 21969 18538 69912 103468 19386 234865 11799 59004 52276 20610 20878 59015 22196 69736 100043429 16319 110379 229615 20877 170762 108989 231042 227699 223921 227720 445007 269113 66679 RECYCLING PATHWAY OF L1%REACTOME DATABASE ID RELEASE 96%437239 Recycling pathway of L1 56613 74947 73086 20404 11771 11772 103967 71770 22350 26413 71653 20111 232910 11773 13430 18222 110651 16571 20112 16728 67300 13429 12757 19684 12934 17698 67071 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME%R-HSA-674695.5 RNA Polymerase II Pre-transcription Events 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 20924 23894 14884 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 76246 21343 209361 214498 226182 12454 229906 66317 235459 24074 83602 58202 68153 235497 74197 67923 22083 27224 27632 24116 12455 72949 54624 13716 63856 64144 20926 93736 70122 74427 73473 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.5 Myoclonic epilepsy of Lafora 13853 105193 667035 22190 14936 27357 53412 NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.5 NEP NS2 Interacts with the Cellular Export Machinery 18141 107939 69482 71805 54563 19069 70699 72787 103573 18226 218210 69912 103468 19386 234865 59015 69736 110379 19384 170762 108989 231042 227699 223921 227720 445007 269113 66679 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.2 NOTCH4 Intracellular Domain Regulates Transcription 328572 12914 15213 14534 15214 18129 18519 18128 333639 18132 17127 15205 270118 15208 19664 14257 103806 PTK6 ACTIVATES STAT3%REACTOME DATABASE ID RELEASE 96%8849474 PTK6 Activates STAT3 20848 20459 12702 106766 SIGNALING BY RNF43 MUTANTS%REACTOME%R-HSA-5340588.4 Signaling by RNF43 mutants 14370 14367 14368 16974 207742 16973 14366 22416 INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME DATABASE ID RELEASE 96%5659898 Intestinal saccharidase deficiencies 226413 69983 CLEAVAGE OF THE DAMAGED PURINE%REACTOME DATABASE ID RELEASE 96%110331 Cleavage of the damaged purine 319178 319183 319182 232440 319190 57321 319176 319181 234258 319152 18294 21749 497652 21750 319169 268395 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME DATABASE ID RELEASE 96%2243919 Crosslinking of collagen fibrils 16949 94352 16950 69675 67573 18542 24087 21892 12153 16948 MATURATION OF DENV PROTEINS%REACTOME DATABASE ID RELEASE 96%9918432 Maturation of DENV proteins 66357 68563 66624 12282 13200 233726 11806 16646 12317 66286 14827 18453 103573 18452 20014 66861 235623 103963 667035 12330 22190 69038 13135 76687 69019 18451 16211 100039592 16648 100037258 56529 67075 171210 13480 22196 13481 381686 16649 14828 320452 67838 80286 18107 68292 19092 16430 DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.6 Downstream TCR signaling 12234 77647 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 192656 12042 66413 26965 667035 19211 22190 240354 59029 26409 16331 67089 103583 70247 12500 12501 12502 12504 18708 18709 18706 18607 74769 100041766 216150 93765 66589 18761 22034 14969 14968 68652 21762 22123 12675 108723 19179 19181 19182 23996 19184 18033 26440 19166 216080 18035 16818 19167 26441 26442 69077 66997 23997 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME DATABASE ID RELEASE 96%164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 252903 12487 232910 11773 12504 11771 11772 71770 15007 16818 12526 12010 11768 11769 108012 11764 11840 107975 11765 108664 11767 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME%R-HSA-8943724.2 Regulation of PTEN gene transcription 216848 13626 107932 52615 19646 234366 26413 26417 21907 56233 19712 245688 22059 19016 12418 23942 17192 13498 14013 68877 229542 12151 19763 20613 54383 13619 56717 13653 241915 12416 19821 15184 99982 217864 15183 66508 116871 545987 116870 54170 20583 14056 11909 52187 494448 68576 66096 83409 74370 68441 30951 268706 245670 16476 99377 433759 56716 15182 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 96%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic 270160 28169 54160 74947 108148 56494 16570 107338 66111 54399 53357 109181 73470 16563 16568 234663 213827 11844 53334 68097 73804 67511 53598 56358 56444 67665 22428 56455 13191 12121 76895 12344 26951 18476 59288 16594 18475 229841 668303 16579 232943 75985 19348 71819 16593 105785 16551 22365 110033 17113 13047 209737 11840 74764 18472 235661 18195 76932 73296 108123 108124 16004 74375 76332 16834 226089 76688 270192 53611 56367 13427 319642 102339 19157 19346 13426 67474 98910 19159 58244 13424 19158 70646 228421 72318 78304 27277 338337 73124 104303 17957 67542 26934 78689 242406 56382 53330 228960 69834 224705 76899 245944 97484 68505 233824 54214 232286 240641 68299 22319 269152 227746 16565 70297 16564 16552 16580 16581 67023 16561 16562 72772 16558 70218 56418 20932 75050 16554 286942 71116 16578 319991 16572 66251 224630 16573 16560 56447 54161 18783 77038 56389 59042 76877 69654 11650 228998 68137 66905 17155 17156 230815 11843 19324 66913 12343 12345 100042773 20333 11842 16569 12340 50797 70349 16571 12847 54130 14423 226407 19330 17158 76308 100042343 19338 ASPIRIN ADME%REACTOME%R-HSA-9749641.4 Aspirin ADME 76408 394433 71773 100727 100559 436059 231396 13106 394434 94284 552899 223337 72303 107141 56448 13114 12780 11657 104158 20501 12215 107146 233799 12038 233801 272428 435528 22236 94215 72094 394436 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%156711 Polo-like kinase mediated events 328572 12532 75660 268930 12442 108000 18817 14235 19646 22390 17865 72568 12530 231506 629959 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.5 Hydrolysis of LPE 74182 232889 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702636.2 tandutinib-resistant FLT3 mutants 14255 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-HSA-3134975.4 Regulation of innate immune responses to cytosolic DNA 56480 446099 54131 207521 58203 20821 384309 22040 72935 72512 69807 667035 22190 DEFECTIVE CYP27A1 CAUSES CTX%REACTOME DATABASE ID RELEASE 96%5578996 Defective CYP27A1 causes CTX 104086 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH12 LOSS OF FUNCTION%REACTOME%R-HSA-9918440.1 Defective visual phototransduction due to RDH12 loss of function 77974 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159227 Transport of the SLBP independent Mature mRNA 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 69912 13684 103468 19386 234865 59015 69736 21681 110379 170762 108989 53319 231042 227699 223921 227720 445007 269113 66679 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.4 PRPP biosynthesis 19139 110639 75456 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME%R-HSA-210745.3 Regulation of gene expression in beta cells 103988 18508 16334 21405 18088 18096 56458 15376 18012 18609 20526 378435 15377 11651 320995 15874 11652 30942 23797 DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME%R-HSA-5083628.3 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 13138 68273 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 18747 18639 18640 19052 170768 21770 19053 51792 270198 73699 18749 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME DATABASE ID RELEASE 96%1474244 Extracellular matrix organization 13406 60409 12550 244431 13405 69675 20650 13528 13527 20649 17182 24051 20648 20391 24053 24052 18787 16651 268534 20392 16416 14161 18810 21825 110135 99571 16948 16949 94352 13038 16950 109711 67573 17395 268958 13039 12339 23830 17394 17384 56213 17388 23948 58223 17229 72947 50817 18452 269120 72902 12305 18550 17150 216760 76293 14115 14114 170725 18214 19035 64706 11502 50530 240047 18451 11501 17391 381122 23876 216616 14119 58859 22288 73647 14563 268935 12335 12338 12215 30800 12337 13717 12476 23993 12334 17385 12336 17381 71753 57764 69543 13497 16542 320452 16456 12380 12333 17228 15896 12817 12816 22139 12815 12814 12831 12813 94216 22072 12830 373864 12821 107581 77018 12819 53867 16412 12829 12828 12827 12826 12825 69700 12824 12822 19164 71355 12841 12823 73368 12840 59287 213945 12818 245026 140709 237759 12839 329941 12837 12836 12835 12834 11492 12833 12832 18453 50701 16419 232345 23794 13033 30806 271127 208936 21858 21857 11504 16410 21803 21808 13003 17387 17389 17393 13035 240913 56693 269132 237360 12032 14789 104099 330119 13179 21809 12406 216725 268977 18822 16997 26432 13138 16998 26433 20750 210530 12111 56401 320910 76477 13004 18542 234407 108075 16420 241226 17022 12154 14264 24087 17967 21892 12153 15529 213119 20971 20969 20970 16621 18189 12505 19280 12159 17392 15530 83995 12361 18590 11487 11491 14173 12367 192897 109700 16398 18074 16400 16403 18073 16404 11603 16408 66695 15898 17183 381924 17180 16407 21960 16409 18198 22329 16775 319480 81877 16776 16421 329278 16777 21923 14218 666279 16779 83964 12950 16780 16423 228357 226519 16411 16399 14268 16414 16782 78369 16401 16772 67374 16402 11490 23928 15891 11489 16773 12845 16774 14118 22370 13040 13030 18591 12843 12842 18613 17386 15894 12162 66473 12156 17390 18815 20692 18750 PKB-MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 96%109703 PKB-mediated events 18576 11652 DEFECTIVE SLC5A7 IN THE NEUROTRANSMITTER RELEASE CYCLE CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.4 Defective SLC5A7 in the neurotransmitter release cycle causes distal hereditary motor neuronopathy 7A (HMN7A) 63993 GLYCOGEN SYNTHESIS%REACTOME%R-HSA-3322077.9 Glycogen synthesis 13853 667035 105193 22190 232493 14936 74185 27357 216558 53412 72157 SENSORY PERCEPTION OF SALTY TASTE%REACTOME DATABASE ID RELEASE 96%9730628 Sensory perception of salty taste 20278 546729 20276 20277 240669 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.4 NCAM1 interactions 12291 239556 14573 13004 20452 12295 12296 12297 12298 14586 19122 14585 19197 14588 17967 12830 11603 12292 12289 12829 12828 12827 12826 21367 12841 12840 245026 12839 18188 12835 20450 12834 58226 11876 12288 12833 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.7 Cell surface interactions at the vascular wall 11931 11932 11933 22612 12389 14786 20737 66053 16331 14360 20416 15529 20971 20969 17096 18176 20662 16416 15461 20970 12505 18708 18709 56744 18706 74769 238055 18693 14061 83995 14733 16149 268373 57274 21912 80879 20501 19123 12215 22363 12481 18803 20339 17289 69524 19261 19128 108078 12523 22364 20343 14456 20345 13052 20340 64435 270152 13449 71683 16456 12506 58217 171486 18106 16069 16400 16403 16408 16412 14127 243816 16409 83964 16423 16411 14268 16414 16401 16402 67374 21687 11600 17075 18613 21933 53896 21824 30962 50934 19124 68891 19247 20540 11601 330836 50915 11602 15170 17254 20344 20539 26570 17319 16410 21803 16728 16818 17136 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-HSA-174430.6 Telomere C-strand synthesis initiation 18969 18968 19075 19076 68964 108689 57321 69535 28113 101185 21749 497652 21750 GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702590 gilteritinib-resistant FLT3 mutants 14255 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 96%1483213 Synthesis of PE 14245 71760 99712 75320 64898 68671 12651 237928 320951 28042 12660 64899 TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%416993 Trafficking of GluR2-containing AMPA receptors 53623 14799 21912 243547 74053 14802 18195 18693 11771 18752 18751 18750 14800 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME%R-HSA-174437.5 Removal of the Flap Intermediate from the C-strand 68275 18971 327762 68240 18972 14156 19891 22427 57321 67967 28113 101185 21749 497652 21750 69745 18538 SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME%R-HSA-3232142.5 SUMOylation of ubiquitinylation proteins 18141 107939 69482 71805 17246 18854 54563 19069 70699 72787 19720 18226 218210 69912 103468 56469 19386 234865 59004 59015 22196 69736 110379 170762 22346 108989 231042 227699 223921 227720 445007 269113 66679 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 96%5654720 PI-3K cascade:FGFR4 327826 14172 80857 14170 14180 14177 64654 14175 14388 14173 14164 83379 80903 18708 19247 14186 18706 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8853383 Lysosomal oligosaccharide catabolism 110173 73744 17159 17160 ORGANIC CATION TRANSPORT%REACTOME%R-HSA-549127.4 Organic cation transport 20518 20517 30805 20519 18400 108052 27411 20520 67473 67582 70840 242126 CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1793185 Chondroitin sulfate dermatan sulfate metabolism 11881 15931 12111 121021 212898 13004 244757 78752 72136 60322 269941 58250 74241 53374 77590 319901 59031 29873 338362 13003 110006 77042 71797 15586 109685 70893 234356 15212 78923 15211 12032 13179 15932 12091 THE FATTY ACID CYCLING MODEL%REACTOME DATABASE ID RELEASE 96%167826 The fatty acid cycling model 22229 22228 20523 74011 22227 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) DURING GASTRULATION%REACTOME%R-HSA-9758919.3 Epithelial-Mesenchymal Transition (EMT) during gastrulation 13813 20613 20997 14182 AXONAL GROWTH STIMULATION%REACTOME DATABASE ID RELEASE 96%209563 Axonal growth stimulation 18053 11848 192662 18049 CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.10 Cell-Cell communication 233833 16451 20665 12388 232440 19089 12387 13200 13626 12550 319149 20586 11472 20779 13858 15077 104836 13345 19303 12558 21417 52615 19646 26413 26417 14360 21418 22325 13001 13000 100039026 17869 245688 11474 29875 18109 209462 18810 22160 16480 18708 18709 16452 18706 22330 74769 66357 109711 224619 66286 228839 18550 18553 69019 93759 226970 73341 56529 12476 12695 22177 224912 56217 13017 13016 19261 16456 20683 93742 56513 12488 50791 68794 20163 54631 170643 21754 170736 74202 54353 57342 67703 218952 243911 16202 668101 225341 12821 16412 330662 56198 140580 192176 77630 11492 239096 11797 12385 59058 110751 12564 15426 66624 16201 330914 20613 12552 57875 15227 11798 73178 54721 99982 76687 228913 11727 14083 17974 217734 99011 20740 17973 11735 20742 19645 22323 12330 20901 60611 16601 114142 12741 16600 53325 17246 19229 16193 12555 93760 13430 12561 21762 22123 19179 21844 19181 19182 64945 67956 23996 71740 19184 105837 18033 58235 26440 19294 12361 19166 94332 71908 19167 15220 60363 26441 54420 58187 26442 54419 69077 12738 66997 93737 23880 23997 54725 56863 12737 56436 75677 17463 215654 57296 320873 20422 12565 24136 26445 241201 26446 12563 19172 53624 19173 12562 19175 12739 15376 19697 12740 19177 12560 12557 12554 26443 56492 26444 16195 22431 19170 621628 21423 18759 14694 192897 75339 66413 330222 192173 667035 56173 22190 239857 16403 242653 239931 59029 230738 18746 16194 67089 76007 56805 70247 58220 21406 237979 21885 58998 18554 227485 18417 227377 114141 16780 16423 75234 16782 15267 319168 16774 319167 13040 13030 76850 239528 319186 319178 319183 319182 236511 319190 319176 319181 19353 20014 213988 103963 217351 60595 214150 69038 13135 19247 20583 14056 18717 15170 17454 319169 57377 20848 625328 78303 319188 15270 433759 624153 15182 16430 14376 382522 EXTENSION OF TELOMERES%REACTOME DATABASE ID RELEASE 96%180786 Extension of Telomeres 208084 14156 72171 245474 214987 214901 20174 68964 72107 108689 69535 66181 12566 216853 68147 16881 52530 21752 18969 18968 19075 19076 28113 101185 69745 327762 12428 269400 22427 57321 19687 19718 69263 56505 21749 497652 21750 18538 105522 12144 68275 106344 72151 18971 67857 68240 18972 19891 12427 52036 67967 TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME DATABASE ID RELEASE 96%948021 Transport to the Golgi and subsequent modification 193813 12068 53618 54160 317717 56494 60409 89867 11733 235416 11735 216131 107338 67231 14595 66111 640524 66890 20742 20741 54399 20743 217615 338366 12640 68947 80297 20451 234663 224139 21802 213827 11844 53334 68097 241230 67511 53598 56358 20450 14799 56444 67665 104318 22428 56455 13191 71665 12344 59288 56336 56386 242362 105785 11840 64138 235661 18195 108123 108124 57370 76332 53418 16834 56375 110379 11839 13427 102339 13426 13424 99412 338337 17957 67542 16334 66397 97484 17309 69608 233824 218811 99683 56418 70361 77371 20334 66251 56447 54161 77038 12836 56389 59042 56395 69654 16866 228998 68137 17155 67091 17156 20703 230815 11843 66226 19324 66913 105522 243819 14067 69162 14275 12793 12343 67857 12345 100042773 98388 20333 11842 215474 207352 74498 66682 12340 103534 50797 52036 76983 13032 70349 245828 12847 12794 54130 240667 67727 269181 214895 59005 217664 14069 78232 107895 56041 333883 21787 27096 20443 72978 17308 227648 17158 76308 20440 76510 67569 20739 100042343 20740 50907 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN CELL CYCLE AND PROLIFERATION%REACTOME%R-HSA-9825892.3 Regulation of MITF-M-dependent genes involved in cell cycle and proliferation 21415 12387 12575 21414 21416 16842 15254 17295 12443 12566 20466 21385 18817 433759 12578 12531 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-HSA-198933.9 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 270152 58217 246256 12550 15896 15006 12483 240095 667803 232801 14991 30925 217304 26904 14130 217306 100043861 12266 16641 16408 16643 232790 16412 15898 71326 140792 12500 50928 52685 12501 75345 22329 12502 21947 16421 57781 17086 231805 170741 84544 16414 243958 16401 78369 243864 54215 75863 629970 100038830 52855 15007 328833 12010 12526 83382 246746 12478 20612 12520 319352 27007 54698 18146 12480 20400 12525 225825 224840 17470 140497 23900 15894 83433 22177 19294 217303 20343 13052 14129 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.5 mTORC1-mediated signalling 54170 208643 52187 68576 66096 83409 74370 68441 56717 268706 14225 67605 245670 667739 13631 56716 75705 66508 545987 13685 13684 EPIGENETIC REGULATION OF ADIPOGENESIS GENES BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9851695.3 Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes 232440 20602 319149 23989 19645 66853 59024 11450 14732 18631 327987 15077 57435 20249 68801 66310 21835 140858 14311 68975 14081 234959 213464 12606 20181 11350 28077 70208 12491 21664 55982 171285 23808 11520 56771 15267 319168 319167 19014 264064 319186 319178 328572 319183 319182 67279 319190 21372 16475 231051 57875 17977 67278 23945 319176 19017 16890 16956 319181 17978 81004 14245 69790 56310 103968 26896 15183 20185 93759 17979 216154 67800 12914 56406 51813 11770 26424 319169 22289 27273 69792 67512 625328 67381 78303 319188 15270 170826 12568 624153 381022 382522 MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.5 MAPK6 MAPK4 signaling 233833 56436 17463 57296 12534 20422 26445 26446 19172 19173 56458 19175 19177 26443 26444 19170 12445 260409 66413 667035 22190 59029 67089 70247 18747 81489 17869 15507 545156 104252 58804 19373 224105 19374 218294 76850 18479 140486 239528 18612 17165 235072 236511 18481 225724 50772 229776 103573 19353 213988 217351 214150 17979 17454 21762 22123 19179 18749 19181 19182 23996 56484 19184 16476 26440 19166 19167 26441 26442 69077 66997 23997 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME%R-HSA-5619052.4 Defective SLC9A9 causes autism 16 (AUTS16) 331004 HEDGEHOG LIGAND BIOGENESIS%REACTOME DATABASE ID RELEASE 96%5358346 Hedgehog ligand biogenesis 56436 17463 57296 20422 26445 26446 19172 11491 19173 77583 19175 19177 26443 26444 19170 269523 66413 667035 22190 59029 67089 70247 74126 20423 13363 214240 226861 18453 216440 103978 66753 16147 116891 20338 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 RHO GTPASES ACTIVATE KTN1%REACTOME DATABASE ID RELEASE 96%5625970 RHO GTPases activate KTN1 19353 16709 16572 11848 16573 16593 56212 74764 16594 232943 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 96%5637810 Constitutive Signaling by EGFRvIII 12539 13649 12402 18176 14388 20662 15461 18803 13645 18708 18706 20416 15519 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.5 Defective SLC26A2 causes chondrodysplasias 13521 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5660883.5 Defective amino acid transport by SLC7A9 causes cystinuria (CSNU) 30962 20532 NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 96%2980766 Nuclear Envelope Breakdown 18141 23825 107939 69482 12534 71805 54563 19069 70699 72787 64899 18226 218210 14245 18751 64898 69912 103468 382030 22367 19386 224640 13726 234865 12442 59125 67181 59126 217718 59015 69736 18817 110379 16906 170762 108989 231042 18750 227699 223921 227720 445007 269113 380664 66679 DEFECTIVE LFNG CAUSES SCDO3%REACTOME%R-HSA-5083630.4 Defective LFNG causes SCDO3 18129 18131 18128 18132 16848 GLYCOPROTEIN HORMONES%REACTOME%R-HSA-209822.3 Glycoprotein hormones 16326 22094 16325 12640 16324 16323 16866 16322 14308 PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.4 PI3K AKT Signaling in Cancer 12575 268980 18183 83961 320207 100042150 20779 17295 11651 11652 22324 18710 12576 14255 14360 327826 13649 21802 12015 12371 78757 30955 18708 18709 18706 18607 74769 18707 12487 12519 12524 17246 12223 71920 13874 15200 211323 19354 22084 12064 12675 67605 14388 15234 18212 56484 18205 78405 11839 13645 80903 384783 14186 14165 83490 18596 14389 77647 16367 18213 14172 80857 14170 14180 14178 56458 14177 67112 64654 14175 14174 14173 14164 83379 19211 13983 13982 18595 58988 12478 18591 54601 56212 56717 19353 56637 14256 227743 19247 104709 13866 109270 15370 606496 16818 16590 56716 23797 COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 96%1442490 Collagen degradation 13038 17395 11487 17392 17386 11491 17394 17384 17388 58223 50701 72947 83995 18550 12817 12816 13033 11502 12821 107581 77018 12819 17390 30800 12822 12841 17385 12823 17381 71753 12840 17387 12818 140709 17393 237759 12839 13030 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%R-HSA-201722.7 Formation of the beta-catenin:TCF transactivating complex 21415 232440 12387 319149 20586 16842 15077 66310 140858 21752 213464 21885 17869 75410 21886 21888 23808 100683 15267 319168 77578 68911 12006 319167 80288 319186 72135 328572 319178 319183 319182 81601 21414 319190 21416 17283 12399 319176 319181 319152 56505 214498 12914 21887 235497 319169 625328 78303 319188 15270 433759 624153 382522 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-HSA-9006936.9 Signaling by TGFB family members 233833 16998 68010 17872 320910 65112 20602 14479 108075 16420 211586 170749 12402 56207 241226 23893 21781 12165 11705 110542 218441 12154 17129 18121 55994 83554 12166 66105 11545 12167 12168 97064 11482 14314 20901 26413 18787 26417 20482 19047 20481 17869 94093 17125 17126 17127 17128 18109 16416 66313 17130 109689 17131 216869 21815 328572 22284 103573 228839 18550 16477 21812 21813 107951 20185 12579 22608 12454 18002 13559 104394 21413 17877 17878 17927 19042 11481 17928 14225 12455 12622 72949 269275 11479 75788 19650 16456 18762 11848 102098 20683 70737 93742 56513 14173 21423 667035 22190 21406 20181 14106 14313 66556 16412 19164 19165 100042305 208117 19401 59287 100039623 16324 264064 76850 239528 12843 236511 56424 17283 19045 16419 83814 213988 217351 19046 214150 93836 67821 51813 12156 17454 21858 21857 15201 16323 16410 22192 16322 21803 21814 21808 118445 67903 17387 11480 433759 216080 17389 21809 268977 16997 SIGNALING BY EGFR%REACTOME%R-HSA-177929.6 Signaling by EGFR 11487 58194 11491 20408 12402 56324 24063 20779 19272 24064 15239 16206 12223 20404 239463 94212 71920 20844 13874 20405 13858 15200 19303 208994 667035 19248 22190 13854 19247 12988 20416 54126 13649 21802 13859 18176 20662 14388 15461 11489 18803 11839 13645 18708 227290 18706 SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 96%1295596 Spry regulation of FGF signaling 19052 109880 19053 51792 667035 22190 12402 24064 19247 17346 26413 26417 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.5 E2F mediated regulation of DNA replication 18969 18968 12534 19075 19076 211586 13555 73699 19645 21781 50793 19052 18392 18393 19053 66634 51792 26428 26429 56452 RIBAVIRIN ADME%REACTOME%R-HSA-9755088.3 Ribavirin ADME 71279 18950 269346 63959 11534 18102 11486 76952 18103 114304 16434 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME%R-HSA-9027307.3 Biosynthesis of maresin-like SPMs 13106 72303 13077 56448 13114 ACTIVATION OF STAT3 BY CADHERIN ENGAGEMENT%REACTOME%R-HSA-9958825.1 Activation of STAT3 by cadherin engagement 56436 17463 16451 57296 20422 12388 26445 12387 26446 19172 12550 19173 19175 19697 19177 20779 26443 26444 16195 19170 104836 66413 667035 22190 59029 16194 67089 70247 22325 227377 75234 209462 330662 13040 140580 16480 13030 16452 22330 11797 12385 12552 224619 11798 19353 54721 226970 16193 21762 22123 19179 21844 19181 20848 19182 23996 19184 18033 26440 19166 19167 26441 26442 69077 66997 23997 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME DATABASE ID RELEASE 96%5663213 RHO GTPases Activate WASPs and WAVEs 17973 105855 242687 330319 76884 76709 19353 73178 11308 12229 56443 108100 11461 26413 101314 26417 80987 68089 67771 11867 11350 56378 66713 74117 245880 14083 22376 215280 11465 68524 50884 83767 20430 329165 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.5 Conjugation of salicylate with glycine 435528 107146 233799 233801 272428 CHD6, CHD7, CHD8, CHD9 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943962 CHD6, CHD7, CHD8, CHD9 subfamily 328572 319178 319183 319182 232440 12387 319190 319149 109151 13018 319176 17135 319181 72293 241128 15077 320790 140858 18104 18024 71389 12914 16002 56811 319169 625328 15267 78303 319188 319168 15270 12006 319167 67772 624153 319186 382522 DEFECTIVE HDR THROUGH HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF BRCA1 BINDING FUNCTION%REACTOME%R-HSA-9704331.4 Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function 12021 81601 327762 20422 233826 19361 114714 22427 19362 11920 12189 12190 237911 57434 19360 225182 26909 17535 21975 19363 19364 12144 27354 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.5 Free fatty acids regulate insulin secretion 18796 18797 14672 14682 74205 18795 12491 14676 233081 14675 50790 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME DATABASE ID RELEASE 96%975110 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling 17874 54123 16179 170743 93765 66589 22034 81897 266632 GENE EXPRESSION (TRANSCRIPTION)%REACTOME%R-HSA-74160.9 Gene expression (Transcription) 20682 217031 226976 12389 208146 66853 18631 76719 57435 68801 75812 21835 14311 12640 69556 69612 101206 14081 13486 217588 54194 108946 67933 665775 75565 228714 67773 239510 21664 77305 269061 18550 20869 64930 66508 545987 54170 22084 52187 68576 66096 83409 74370 68441 19042 268706 83701 245670 20683 18044 18045 18046 14732 20249 81898 13436 13435 13433 14102 12362 16396 670717 108155 56424 21933 22061 12028 11727 68626 64144 20926 93736 70122 74427 73473 12322 12323 108058 12325 18747 12491 12418 54343 11569 77683 22166 20937 84505 12151 17248 17165 19763 12428 17246 54383 13619 110147 26399 241915 12416 19821 12579 12578 16193 494448 12427 12608 30951 12064 14812 13388 16449 384091 666609 75339 27374 20638 56698 67332 29813 59092 50883 228829 74522 12326 14811 20620 70625 68975 227644 13865 66653 243963 77634 234959 20841 12419 102209 21418 330959 76184 75627 94112 15213 67268 70208 17988 21849 69020 13649 21802 14723 55948 94093 228876 15111 67731 268417 14751 23942 209225 56771 50493 21825 80509 104625 22160 21815 67911 214669 226896 240068 13395 108083 21833 15257 13038 77827 18983 98386 13039 210104 384763 239985 72611 269704 12702 14462 16854 14461 228839 14460 71361 14463 16477 67065 233107 71752 14776 74414 56310 233863 72780 72308 237775 66596 208043 78929 26896 544971 14800 70239 15258 269252 218772 26939 19411 67486 103988 70408 52897 20018 75747 69870 80707 70428 54526 67371 16880 218832 14534 67005 17700 20016 244556 98488 12857 12909 110109 619310 12450 12452 69131 30944 237758 53621 75284 110323 72322 19664 14000 72068 229543 14579 70422 12861 109077 232791 68510 19650 71177 17863 18987 19651 210925 12862 109019 17865 18130 12868 75137 68943 77065 66142 269344 216848 69917 232232 93697 12866 68991 12865 192657 233056 69882 100041785 72656 208836 231571 77519 218333 109648 71957 18129 101861 18131 70885 170936 71793 18132 225283 107932 57432 666581 70470 12662 675812 72119 243834 170787 18148 53376 19211 333182 22775 239546 230899 75605 68428 16184 216456 16183 434377 66494 110052 100039786 19712 19713 71131 619331 26992 243906 15510 22648 381549 71063 319974 68742 235682 68094 83796 83797 57376 72720 19246 243743 244713 544922 380975 72306 268936 229542 434178 22658 12705 22750 17684 23988 67279 19258 72154 59027 67057 225872 17283 17992 69076 18718 18741 74400 15228 56353 230162 72723 22704 14229 22757 226830 70315 21349 210135 93836 193452 18986 11864 17979 67821 244349 80902 13866 13864 74747 210503 93681 57264 26424 232784 330301 74120 18519 449521 245368 15370 109594 17702 22654 16909 11783 56707 16825 57745 69562 242109 64384 22761 30942 15378 195522 77044 18534 103836 22632 20750 269870 12020 20393 20375 22696 18854 245595 56314 353187 70227 79221 667501 110616 57230 11816 21429 59024 20019 327987 269003 72180 21340 236193 21339 432769 21341 66105 64424 67296 22130 52712 75316 231866 70333 233904 116848 22294 66136 20135 20017 234725 192292 83766 80751 23957 21907 11350 20482 20492 74570 72290 20481 116748 20183 20182 71041 75410 101095 238690 17125 17126 17127 17128 69181 75692 76073 17192 12741 66313 17130 21981 17131 17132 228140 67235 268859 56744 103806 56525 14312 16600 70088 13496 53325 69125 22640 209456 11604 319955 219024 106298 228491 219103 333639 22284 56456 18124 66813 53892 22062 56200 319801 213011 223272 99890 69790 22678 68527 58184 19885 243372 22026 225998 52679 50496 22608 13559 104394 241764 12858 93760 233893 66923 107986 353310 76390 21762 13198 22123 14634 13197 14633 19179 57748 19181 14660 19182 67956 23996 268973 19184 75788 18033 230784 26440 16653 19166 170826 20463 19167 170574 12981 26441 12978 74352 26442 64050 69077 76367 66997 381022 23997 69260 216151 14381 56436 14377 17463 78893 57296 19293 20422 70472 26445 16334 26446 327963 19172 69228 19173 225655 19175 56458 19697 239652 19177 52846 21402 94223 78251 26443 21388 26444 18091 332937 19170 21423 231464 67010 232854 66413 22709 26965 70650 16179 667035 18387 22190 18390 18751 64058 240064 59029 223828 21408 13983 67089 75613 14219 70247 21406 68744 22260 17708 20181 17709 22337 72198 17710 19013 22693 16408 13982 12795 22025 14431 19883 26913 11835 72739 18227 72556 14815 26381 272347 26380 208727 26379 19016 57913 22196 16399 100043429 12366 16401 26423 16402 19401 106931 12368 21834 20787 18667 233060 69234 19360 56338 13831 264064 17535 12053 21975 12359 18022 19364 84682 27354 15978 12021 12843 12842 20807 81601 56187 327762 54601 19352 17386 19361 330463 170740 243621 22427 333654 12399 19718 192651 69263 20371 15574 20604 11920 16009 16006 12189 83814 22689 235610 68036 231724 12227 237911 15185 19355 12122 66262 225182 12142 15184 26909 22751 18538 27274 235559 11863 17433 12144 20527 216154 68275 20467 106344 78783 72151 211651 14088 68240 51813 12156 252870 19891 72230 15469 212712 12177 19367 69792 19356 12417 15205 20878 20466 12649 108961 217232 18996 56317 18997 59008 67381 19015 66156 72805 216080 12905 69957 219022 17222 22339 75430 56222 68612 666311 52563 15182 22194 71393 68999 15194 52206 12226 100039535 319530 52717 15161 244219 99152 22690 668450 17187 12534 100041581 56275 12387 20602 11906 23989 67155 20586 170753 20779 20588 20587 56461 17295 60599 67338 270118 235956 17191 13345 21936 241196 235028 26416 433766 66214 12005 29808 16656 234366 26413 18787 26417 240087 77976 12545 107568 67370 28077 56233 19094 234594 382985 15214 244216 54401 171285 21420 21419 19014 11865 328572 19285 21372 17977 74322 19017 103573 17978 59035 81004 66993 17260 15183 20185 93759 217166 12914 56406 11909 640703 18019 20656 56484 16476 18477 21672 66899 22627 12569 12568 12125 14103 12532 18128 56438 55982 93762 22385 12918 57875 16956 50724 60406 94246 100041953 16147 71954 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 14415 74320 14417 68188 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 12447 56371 27401 13163 12448 12576 73699 11799 19052 19053 51792 20877 431706 26931 76246 214498 66317 235497 22083 54624 18861 17685 17350 70127 21872 29861 269397 19708 268996 68705 98053 13871 12055 66420 12054 69833 67710 77045 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 21679 15267 21676 319168 21678 319167 14281 76850 239528 319186 21677 319178 319183 319182 236511 319190 18432 241113 56717 319176 319181 213988 217351 56637 214150 227743 19247 116871 116870 14056 17454 319169 109270 105787 67512 108079 20846 19079 108097 625328 78303 54427 319188 100039610 15270 622480 19082 56716 624153 23797 382522 233833 21415 232440 13626 319149 22628 16842 22612 11651 11652 11450 15077 66310 140858 97064 52615 19646 213464 74068 101867 210510 74691 57746 214162 98558 13001 83456 13000 330890 100039026 72634 17869 71981 245688 13206 17864 66715 22601 94244 57749 83561 23808 11520 78757 108099 12477 18607 18027 18029 21414 20823 21416 18032 231051 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 229906 235459 194388 24074 18140 83602 58202 68153 74197 22289 67923 27224 27632 27273 24116 12455 72949 13716 63856 11461 22059 15278 21780 16475 67278 23945 101739 16890 52463 17765 14055 14245 21652 74016 103968 16468 320727 208595 214133 103551 67800 11770 21803 54188 11545 15519 54196 19384 69257 13709 12143 18507 12400 225207 20674 192119 23992 53424 21357 22099 22065 12606 18761 22631 22629 18976 433759 16590 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.5 Transcriptional activation of cell cycle inhibitor p21 29813 59092 12575 22059 SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.7 Signaling by FGFR in disease 14389 14172 80857 110279 14180 14178 14177 67112 64654 14175 14174 14173 14164 68705 98053 66420 69833 67710 245841 69920 20022 76007 14182 327826 20020 231329 20021 69241 17749 100043714 14184 67384 18176 14183 20662 15461 244373 21848 18708 18706 68092 433702 20851 20850 75296 360013 432508 67529 13047 20846 14388 20848 18803 80903 14186 14165 DEFECTS OF COAGULATION CASCADE%REACTOME DATABASE ID RELEASE 96%9769726 Defects of Coagulation cascade 14067 19123 14723 109821 22371 14061 14161 22021 14069 56316 19128 14058 14071 105722 14724 22022 54368 110135 14729 99571 PEXOPHAGY%REACTOME%R-HSA-9664873.4 Pexophagy 100756 17966 18412 19305 67443 667035 22190 13819 11920 SIGNALING BY LTK IN CANCER%REACTOME DATABASE ID RELEASE 96%9842640 Signaling by LTK in cancer 74769 56430 18708 18709 26413 26417 18706 NETRIN MEDIATED REPULSION SIGNALS%REACTOME%R-HSA-418886.3 Netrin mediated repulsion signals 210801 13176 22253 18208 107449 20779 19247 107448 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.4 MyD88-independent TLR4 cascade 66105 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 11909 26419 12675 16476 18033 18035 18036 11820 12234 56480 54131 19697 21402 73086 16150 16151 192656 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 80750 223664 107607 69721 231130 270151 11596 22059 67454 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 19766 11797 56532 22030 12475 22031 56489 225471 11796 106759 21353 18034 71648 54123 434174 100041766 14082 66513 93765 66589 19247 22034 66724 68652 20111 216080 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME%R-HSA-389957.4 Prefoldin mediated transfer of substrate to CCT TriC 12469 12461 12464 22327 22152 227613 22153 22142 11461 22146 14976 67199 18637 67951 73710 22145 12465 545486 12466 22147 109054 21454 56612 12462 22151 12467 12468 AEROBIC RESPIRATION AND RESPIRATORY ELECTRON TRANSPORT%REACTOME DATABASE ID RELEASE 96%1428517 Aerobic respiration and respiratory electron transport 68267 69089 226139 100042811 107029 27418 70456 74125 15929 16833 226757 67105 76282 109801 16832 381511 68263 228026 12857 18604 236900 27273 68477 75387 11429 18004 66089 68033 27402 68636 12856 110323 106557 18597 18598 382051 12861 319518 16828 66771 55951 76425 12862 59003 12974 109264 12868 235339 66142 12866 67264 12865 100041785 22273 66694 100042918 66576 14297 67530 544717 56046 100040287 13382 333182 380840 17711 22272 66152 624814 75530 67267 66821 56384 100900 72795 107197 66445 110826 67003 68202 380975 670717 11739 17992 229211 227112 225887 72900 57423 226646 17995 66477 595136 623286 66706 11958 235169 11957 78330 67899 210582 170718 11947 66359 52469 11949 66349 76916 68055 69802 75406 17705 67834 11946 269951 15526 66945 73694 66043 66343 11950 66072 66841 100041835 94281 100039108 66052 432676 64384 67680 228033 66925 110842 74316 70207 231430 20930 66271 67876 66690 76826 69702 66278 208501 54405 17991 66091 14194 69487 108755 66272 239760 56451 68015 20916 66414 20917 67388 71238 68332 66379 68472 104130 75597 66928 18115 22333 15159 68493 76947 67044 67273 68198 56705 66495 68002 67130 66416 68375 66108 52892 66836 212933 68342 76178 66377 68197 227197 67184 100042503 66046 230075 66916 66218 14874 14719 14718 70316 17436 18563 17721 17722 17716 17717 17718 17719 12858 76187 98314 217666 110446 20463 18293 78920 667035 22190 26940 17708 17709 17710 84682 22227 22229 22228 20523 74011 71803 67863 78830 50799 17449 17448 REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.3 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components 20163 109711 21754 19303 170736 57342 73341 TYROSINE CATABOLISM%REACTOME%R-HSA-8963684.5 Tyrosine catabolism 14874 15233 234724 15445 14085 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.5 GRB2 events in ERBB2 signaling 13866 13649 18183 83961 100042150 12223 18176 20662 13874 15461 15200 211323 13645 IRAK4 DEFICIENCY (TLR5)%REACTOME%R-HSA-5603037.4 IRAK4 deficiency (TLR5) 17874 53791 266632 GSD XV%REACTOME%R-HSA-3814836.4 GSD XV 14936 27357 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME%R-HSA-1799339.4 SRP-dependent cotranslational protein targeting to membrane 622534 238217 16785 666669 100040021 13200 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 20818 107513 667618 66256 100040970 20832 267019 67437 56040 66661 67248 217337 100040331 24067 67941 27058 66384 20813 72265 57294 66286 67398 69019 56529 667035 66624 20014 103963 57743 76687 53421 27207 100043039 67097 670832 66212 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 96%198725 Nuclear Events (kinase and transcription factor activation) 21990 56437 14066 17095 12570 20393 15902 15901 17172 20408 15903 14283 211770 16478 17936 73086 107932 17937 11838 13656 13655 381677 26416 17258 26413 26417 21406 19712 19094 73699 110651 20112 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 13654 328572 20807 21770 14282 13653 13712 15904 16477 17260 17261 23939 20111 11909 13430 12569 12568 RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 96%5625900 RHO GTPases activate CIT 67268 67938 17904 11848 13385 11852 11853 17880 381293 77579 19353 71960 233406 17886 19046 329251 12576 17931 12704 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 96%211897 Cytochrome P450 - arranged by substrate type 320997 13120 631304 13118 72054 208285 64385 21391 19223 13124 13121 13075 244209 20181 20186 13123 104086 13122 102294 68165 14149 14148 13087 13116 13107 13115 13106 110115 622127 56050 11624 18984 11622 13082 13081 72303 107141 17977 13088 13077 13072 56448 13076 13114 232174 13079 74134 11529 17978 72082 546726 13110 13113 71519 545817 106648 100040843 13078 13070 11863 11864 18976 FRUCTOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%5652084 Fructose metabolism 230163 235582 16548 225913 20322 11668 11677 DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.4 DEx H-box helicases activate type I IFN and inflammatory cytokines production 72162 17874 54123 18033 13211 19697 18034 CARDIAC CONDUCTION%REACTOME%R-HSA-5576891.5 Cardiac conduction 235281 269717 11931 14226 20266 11932 20265 11933 11937 11938 65973 53313 109305 56188 76757 16514 56461 109552 67972 20271 11941 399548 18160 320707 20272 230103 381290 20274 53419 12322 18159 20273 12323 108058 110876 97064 12325 20192 20269 20191 72821 20866 110880 110891 20190 229709 16438 16439 13400 20264 18747 11928 98660 232975 20541 57780 18125 110893 16440 59095 20928 108017 21954 54378 12288 14169 15257 14168 14167 14166 56808 12295 12296 70357 80334 16520 14463 16518 15258 640703 16515 54377 81905 16529 210741 241769 16526 16527 223604 16535 21388 18091 74571 22063 72258 16528 230899 104158 16506 16493 17380 16508 56543 217826 16511 211480 332396 100986 52150 16525 16530 81904 18519 57814 246133 66240 16509 57442 24046 FREE FATTY ACID RECEPTORS%REACTOME%R-HSA-444209.3 Free fatty acid receptors 436440 233079 233080 233081 107221 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 96%9026527 Activated NTRK2 signals through PLCG1 18212 78405 18803 12064 POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%438064 Post NMDA receptor activation events 12326 14811 18039 216963 14810 11472 20779 19087 19084 23859 14814 52163 14813 12322 12323 108058 12325 26413 26417 18747 100039592 13385 53310 13383 110651 18176 20112 15461 108099 18607 14799 241113 19088 55984 19108 19417 19418 19353 211323 432530 14800 20111 640703 105787 11514 108079 14812 64011 19079 18749 207565 108097 19082 67071 19085 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665737 Drug resistance in ERBB2 TMD JMD mutants 13866 59079 12539 15519 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME%R-HSA-9034793.3 Activated NTRK3 signals through PLCG1 18213 18205 18803 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.4 Membrane binding and targetting of GAG proteins 73711 22088 67123 330192 667035 22190 66914 18108 107305 72543 194309 52348 ACTIVATION OF TRKA RECEPTORS%REACTOME DATABASE ID RELEASE 96%187015 Activation of TRKA receptors 18212 18211 11516 11517 18049 11540 NEPHRON DEVELOPMENT%REACTOME DATABASE ID RELEASE 96%9831926 Nephron development 16371 22431 13388 16449 22417 21410 22412 16372 16869 18993 15378 16848 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME%R-HSA-9017802.2 Noncanonical activation of NOTCH3 22608 100042305 208117 59287 100039623 18131 19164 19165 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.4 Energy dependent regulation of mTOR by LKB1-AMPK 241113 56717 12283 20869 64930 66508 545987 54170 72149 22084 52187 68576 66096 83409 74370 68441 19042 268706 105787 69008 108079 227154 19079 245670 108097 108099 19082 56716 NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 96%350054 Notch-HLH transcription pathway 232232 20602 21372 18129 18131 18128 333639 79221 18132 270118 81004 170787 15185 70315 15184 15183 20185 12914 56233 14534 18519 208727 19664 433759 15182 103806 RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME%R-HSA-749476.4 RNA Polymerase III Abortive And Retractive Initiation 18027 18029 20823 18032 21374 67065 71752 74414 233863 66420 72308 69833 66596 227644 78929 245841 66653 544971 77634 70239 20841 18986 269252 102209 26939 330959 67486 75627 70408 20018 69870 70428 67371 17749 218832 100043714 67005 20016 98488 12909 TRANSPORT OF SMALL MOLECULES%REACTOME%R-HSA-382551.7 Transport of small molecules 68267 117591 114479 27416 239273 114304 107568 13340 269346 63959 110157 11518 19298 13830 18673 52466 15129 15368 15122 11806 238055 18552 18550 18553 11428 18174 242341 68775 74591 53945 15369 11416 30926 27421 76252 20521 11972 108664 54403 66290 20538 67634 238384 18002 26569 14325 246787 117167 22232 640703 11964 23985 26357 72027 110935 13487 11966 74104 100039636 20501 66335 104245 11973 12215 11974 20516 15203 18670 74915 14319 28253 338375 170441 21871 11666 71279 73834 317750 12870 24059 114143 66237 11975 22041 54411 27060 64602 16819 140494 22042 20505 50765 142681 15216 20531 66144 71902 59049 270669 73649 100434 94249 213603 76376 242259 75750 66397 70129 68682 226999 63993 236794 331004 77031 236727 105243 277973 110895 20544 14697 14710 14699 66066 14700 56453 14708 14706 14704 14695 20537 14693 20526 64337 13162 14709 14701 18400 16891 14702 100017 30924 68453 14696 103161 93835 100102 57875 67963 19088 11307 105847 22259 18453 16956 65969 11303 11771 104110 11772 66113 71770 232345 13909 20519 218203 18671 20520 320024 22359 223920 11657 432530 11807 210044 11808 104111 18145 20652 14688 16816 17777 56636 624219 15450 76483 232910 11773 11812 16835 224129 11813 11814 11512 11425 11513 110611 11514 208677 11515 54135 18749 171504 16889 19085 11931 14226 11932 11933 11937 11938 65973 53313 56188 76757 16514 109552 67972 11941 320707 69597 381290 66865 12322 381038 12323 66815 108058 170756 12325 68115 20192 68514 20191 12034 22334 110891 66592 20190 70484 22333 27377 57138 216001 20498 22335 20499 78506 18747 20495 215999 11928 20497 11640 98660 20496 69029 232975 107723 234847 20541 73078 57780 110893 59095 20928 108017 268512 218756 231583 76408 11833 13521 73836 235504 27376 20528 108652 57274 80879 20525 20503 13723 11998 12000 17250 74610 56199 214111 56325 224814 19299 69847 27403 75607 11305 279561 224742 208169 11304 11944 77706 11945 217262 382427 192663 27219 217265 69047 27404 11981 56535 11977 26874 101772 117160 170759 170755 11979 14628 54670 241118 11419 74772 50771 212989 319767 102566 404545 229277 338370 26372 224079 140475 13665 50770 67204 105722 226144 382014 231287 26905 14605 268878 11980 20278 78339 67331 235574 193670 217843 54197 320091 58176 229782 66388 56315 252972 103098 20276 53896 20277 56774 242607 232341 70377 14411 56365 30962 76295 20532 233246 216440 215113 26373 216225 67760 12728 50934 12727 209837 12725 20513 12724 21366 97086 20514 12723 215335 243634 11989 23844 234967 192113 55963 74446 69354 50769 74338 24115 76257 58170 20511 99663 20510 233979 102680 320940 66753 20512 229933 20540 54667 67819 330836 11982 72401 12733 246049 105355 17254 116891 11987 214663 20338 105727 20539 26570 67075 27801 67470 27409 80286 19084 269523 76184 53869 11832 64008 12638 244373 11815 19879 28250 20533 230582 266690 320635 12346 242960 72017 12349 12351 11826 19743 30805 108052 27411 67473 67582 70840 242126 56327 68428 56384 69048 23943 239436 11739 433923 11740 216227 27410 67300 12757 231999 20393 19087 11816 22348 228368 233836 239606 24060 53881 15567 232333 14412 11519 242585 236792 243616 11828 11829 114644 11830 72621 11831 320718 20518 74340 20517 338365 225579 100604 56356 330064 214112 66333 65221 18399 56643 241296 83429 233280 100561 230612 11840 52635 59033 243755 72267 214922 380836 208760 11732 106947 434203 114886 58807 94229 240215 20529 21762 20500 22123 12752 353169 435818 19179 171429 19181 93790 19182 79554 23996 17919 19184 241612 74998 26440 30791 19166 58246 14977 19167 108115 231549 26441 272636 237831 26442 26457 69077 72002 66997 107566 23997 223473 20536 56436 77701 17463 20535 57296 13829 20422 19729 26445 18716 26446 227394 19172 70701 19173 212555 19175 64452 109342 19177 67547 21402 101488 55961 26443 243328 26444 12007 208890 19170 225997 12780 226781 22063 18173 193034 232156 66413 22065 22784 26965 22067 17189 667035 22066 230810 22190 28240 433926 22068 20515 63873 13358 59029 171382 106957 171166 20504 67089 56407 20502 68667 22782 70247 277328 98396 64177 72045 22260 17364 213053 246788 17339 68279 227659 94178 74552 22368 227059 226025 212980 194352 64242 26946 11827 56843 58800 27360 14664 140919 240332 83814 20527 56017 71803 67863 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 96%194315 Signaling by Rho GTPases 12387 12550 56324 20779 56374 15239 381293 20867 12389 83669 20844 76804 18844 108670 12874 59009 232339 107746 14786 223881 208994 26416 108686 66922 227937 20257 67586 71228 26413 68187 26417 93840 11671 327826 22325 77480 19094 54401 57257 246710 50875 29875 20662 19877 15381 83946 106504 52666 109331 16800 11465 263803 12848 52428 19230 13605 17920 270163 22352 20166 19878 236920 76626 26403 13830 56381 16480 19655 68743 53382 20874 15516 213498 70804 100043806 12704 269061 243362 26891 110596 56320 207212 109711 19285 12539 71704 20462 234094 69288 11464 242202 50768 56349 54216 16801 11852 404710 13367 75547 103573 20868 268301 17978 320795 109333 72754 208846 69632 213649 24001 224014 230098 53972 15369 30938 66508 442801 226970 235611 54126 101497 269608 640703 14163 26382 268739 14674 73341 11853 16906 54411 105827 22627 195727 210293 50884 71709 22042 83767 170758 329165 109934 106952 12532 71893 26934 110279 330177 75409 105855 242687 216963 386750 17969 20947 212285 237038 70497 320634 27061 77579 11308 71960 20619 224480 11856 16885 13058 16886 241275 13171 13057 108100 76117 218952 26431 17970 101314 17972 66898 71302 71544 13385 12261 14251 12385 14252 67784 76709 73178 12229 56443 78514 17827 80987 68089 68653 67771 11867 26554 56378 226525 66713 74117 13542 245880 13544 13543 22376 215280 68524 67299 223701 330319 76884 66894 223870 19249 12576 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 217866 19052 105782 73804 14269 19053 22379 51792 80837 20877 214459 381318 14467 66871 52696 226751 26886 76088 66934 218756 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 19418 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 21844 67052 232987 208869 12236 236930 107971 110379 69928 13427 76499 329251 13426 68458 52504 17931 13424 228421 236915 22342 16449 21873 13511 13510 109620 19299 58220 227377 15267 319168 319167 224105 319186 319178 319183 319182 259302 223666 14270 319190 117600 319176 319181 19353 20514 319169 625328 78303 319188 15270 16818 18750 624153 382522 18806 232440 319149 22628 22324 15077 269523 18710 17886 72565 74201 12988 67268 13206 55948 12638 18708 18709 18479 18706 18607 98386 101565 18481 16594 232943 16593 19354 20201 20202 74764 14609 12466 12468 22143 12461 18762 11848 102098 56513 68146 22319 11855 277360 192662 263406 11857 14570 68813 11461 19349 18805 624814 70584 68428 56418 56384 70361 233103 229658 544963 622434 100039786 16572 66251 16573 68202 16412 545156 16443 13726 23943 75739 140579 628438 71782 17207 94176 330662 94190 16709 52331 218581 84004 21917 56491 109904 238130 230972 20430 192176 223921 56419 380664 104445 56389 13836 59079 108037 23988 67938 69922 17904 223435 107589 330914 232906 56212 71435 228359 17283 17880 59069 19046 320271 99982 12345 14083 18016 76378 11352 53332 100039683 233406 17974 67300 17063 17925 14026 20740 214230 17973 20742 20663 241656 18643 18645 15519 11350 21927 74194 64652 216197 12709 20355 233877 22284 19229 51796 53817 69581 238505 75669 22637 213522 329366 56784 20401 233071 75974 12549 58996 66146 225326 214345 208263 192652 239027 70350 74159 71409 74018 106326 244867 70598 192192 319899 260409 57778 386649 226823 21763 18751 216445 69710 211499 244895 216831 268970 70719 328232 244418 101240 232201 73167 78816 228482 72729 104252 11835 231532 18753 68917 27360 69668 14218 71972 225358 214137 75415 171207 74734 71703 77038 228543 58804 56699 214804 269682 77006 223254 102075 66087 11736 23912 207425 19765 54004 20807 73910 83397 269401 434204 207495 76763 94221 11858 213783 13043 100038946 71085 545481 23853 210998 233489 219140 226652 14787 11854 232237 27984 75089 76577 20403 12631 22631 22629 76983 106628 18817 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9034013 NTF3 activates NTRK3 signaling 18213 18205 LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.2 LXRs regulate gene expression linked to lipogenesis 22260 20181 20249 30924 14104 20182 268903 22259 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.3 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) 11684 ER-PHAGOSOME PATHWAY%REACTOME%R-HSA-1236974.8 ER-Phagosome pathway 56436 17463 57296 20422 26445 26446 19172 19173 19175 12317 19177 16150 15006 26443 26444 16151 22319 20619 19170 17874 240095 66413 667803 667035 22190 59029 67089 14991 70247 117149 12491 21899 20193 14161 15007 12010 110135 99571 17087 16912 19171 12475 14827 16913 19186 12229 19188 434174 57743 21898 21354 22320 21356 21355 53421 20909 20201 100043039 20202 66212 20333 21762 22123 12675 19179 19181 19182 23996 19184 26440 19166 19167 26441 24088 26442 21897 69077 66997 23997 SIGNALING BY NTRK3 (TRKC)%REACTOME DATABASE ID RELEASE 96%9034015 Signaling by NTRK3 (TRKC) 16367 19280 18213 58202 19277 20779 18176 20662 15461 18205 12028 18803 18708 18706 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432040 Vasopressin regulates renal water homeostasis via Aquaporins 14702 14696 11998 19088 12000 11828 19087 19084 11829 104110 14697 14710 432530 14699 210044 66066 104111 14700 14688 18747 14708 14706 14704 53869 14695 11827 224129 11512 14693 11513 11514 64337 11515 14709 18749 17919 74998 14701 11826 19085 CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.2 crenolanib-resistant FLT3 mutants 14255 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.5 ATF6 (ATF6-alpha) activates chaperone genes 14828 226641 18044 18045 11911 12317 18046 13198 22027 G2 M CHECKPOINTS%REACTOME%R-HSA-69481.5 G2 M Checkpoints 29870 12534 22628 70620 12566 240087 12545 54401 55948 12428 17216 17215 17217 17218 17219 17220 12544 319152 12427 21762 12442 22123 19179 19181 19182 23996 19184 26440 19166 19167 22627 26441 22390 26442 69077 66997 12530 23997 56436 12532 27214 17463 57296 23834 20422 26445 26446 19172 70024 19173 19175 268930 19177 26443 26444 19170 66413 667035 22190 59029 107823 67089 68251 20184 70247 269582 70681 70238 100039786 27223 107976 210766 22059 59004 15204 19360 17535 21975 319186 27354 319178 12021 319183 319182 81601 50883 327762 319190 22427 19718 69263 15574 11920 319181 12189 50793 18392 235610 18393 231724 66634 237911 26428 19355 26429 56452 225182 93765 26909 235559 12144 68275 106344 72151 68240 19891 22631 19367 19356 22629 12649 78303 319188 15270 382522 MITOPHAGY%REACTOME DATABASE ID RELEASE 96%5205647 Mitophagy 22241 56480 67443 71648 67526 11793 66734 72018 18412 66105 245860 667035 100041766 22190 66410 93765 22334 66589 22333 22335 66169 13001 28185 100043869 13000 100039026 53333 66119 22195 67414 50873 170731 223696 68943 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.5 Fc epsilon receptor (FCERI) signaling 22324 26413 229709 26417 14360 16438 16439 22165 22325 16440 57257 17096 18176 20662 15461 17444 18708 18709 18479 18706 18607 74769 26400 26398 26420 26414 640703 19055 19056 26419 19419 18018 18019 21762 22123 19058 12675 108723 18021 19179 19181 19182 23996 19184 16476 18033 26440 18803 19166 18035 19167 26441 16822 26442 69077 66997 23997 16428 12234 14389 56743 56436 17463 21682 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 12042 66413 26965 667035 22190 240354 59029 26409 67089 103583 70247 26401 14127 14126 14125 14281 224105 234779 19353 20963 12229 100041766 216150 66513 93765 66589 18761 22034 19395 66724 233046 68652 216080 G2 M DNA REPLICATION CHECKPOINT%REACTOME%R-HSA-69478.5 G2 M DNA replication checkpoint 12534 12428 12427 268930 12442 22390 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.3 Toll Like Receptor TLR6:TLR2 Cascade 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 20201 20202 11909 26419 12675 16476 18033 18035 18036 24088 11820 21897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 21899 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 22030 12475 67245 18034 12229 434174 66513 93765 66589 22034 66724 68652 20111 12703 STABILIZATION OF P53%REACTOME%R-HSA-69541.7 Stabilization of p53 17248 56436 17463 26374 57296 50883 20422 228829 26445 26446 17246 19172 19173 19175 19177 26443 11920 26444 19170 66413 667035 22190 59029 67089 70247 12578 22059 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 96%6806667 Metabolism of fat-soluble vitamins 68453 65107 67442 15530 67861 11806 238055 11816 16956 665270 103978 71707 63857 17252 55938 105349 14733 69568 27973 22139 11807 239393 11808 15529 11603 23888 20971 79235 20969 16835 14734 170752 11813 11814 69060 77337 109791 83702 19662 14725 71951 20970 19660 16971 50500 14735 19659 SIGNALING BY ERBB2%REACTOME DATABASE ID RELEASE 96%1227986 Signaling by ERBB2 20459 59079 12539 11848 56424 18183 83961 100042150 84092 20779 12223 76890 13367 22612 11651 13874 11652 15200 211323 14786 19248 667035 22190 19253 18754 14360 67588 20416 15519 13866 13649 18753 75717 18176 14388 20662 17179 15461 18803 13645 18750 18708 23797 18706 MRNA POLYADENYLATION%REACTOME DATABASE ID RELEASE 96%9770562 mRNA Polyadenylation 54196 15381 19655 269061 70616 68598 67959 20462 107701 68092 72047 74326 67500 433702 75956 622469 225027 67996 22608 212880 71713 233073 83486 20382 110809 23983 18521 83701 20383 68479 20222 66899 108014 69207 100040029 319322 19205 27967 107686 76936 384091 666609 24128 216578 68981 20639 229279 68705 20641 98053 667035 101943 20638 22190 81898 66420 69833 67710 20646 245841 69920 67332 20022 20020 231329 20021 69241 17749 100043714 15382 170791 53379 20630 56258 14105 59013 20637 98758 53607 11991 70044 56070 67039 72459 56194 15388 100336 15387 52040 66055 67465 236732 19045 67958 76479 19046 13211 75062 13204 51810 76938 13207 233908 66125 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 74320 68188 54188 MPS VII - SLY SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206292.6 MPS VII - Sly syndrome (Hyaluronan metabolism) 110006 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME%R-HSA-9022538.2 Loss of MECP2 binding ability to 5mC-DNA 433759 20466 REGULATION OF GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9968551 Regulation of GBP-mediated host defense 18712 12362 55948 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME%R-HSA-168277.8 Influenza Virus Induced Apoptosis 21803 11740 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.3 APC truncation mutants have impaired AXIN binding 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.6 Protein methylation 110826 640703 667279 239706 67099 72096 71974 320204 70511 269523 73582 207965 13629 68043 16588 15481 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.3 Adenylate cyclase activating pathway 104110 14680 224129 432530 11512 11513 210044 11514 104111 11515 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 50493 23971 23972 PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-75896.4 Plasmalogen biosynthesis 216820 228061 14712 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%9022707 MECP2 regulates transcription factors 17260 268859 19016 PDE3B SIGNALLING%REACTOME%R-HSA-165160.5 PDE3B signalling 18576 11652 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 96%844455 The NLRP1 inflammasome 12043 195046 12048 ORC1 REMOVAL FROM CHROMATIN%REACTOME DATABASE ID RELEASE 96%68949 Orc1 removal from chromatin 56436 17463 67177 57296 23834 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 12566 19170 66413 26965 667035 27401 22190 59029 67089 70247 12428 17216 17215 17217 17218 17219 17220 50793 18392 18393 66634 26428 26429 56452 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME%R-HSA-1852241.7 Organelle biogenesis and maintenance 20873 15161 68121 76260 81896 12534 69940 78887 16570 12326 71769 107338 21821 22628 76411 277939 225745 241950 231123 66482 654470 67590 74360 73242 238799 18536 109181 26416 13196 68259 66296 214552 59030 74201 18541 76568 29857 66061 16568 213081 213575 67161 19889 19094 53869 71909 140810 237222 52028 67378 93730 102774 74025 17997 12879 67978 264134 18005 215445 73738 68475 53598 208518 67694 108099 380718 100041639 19014 67286 229003 11655 236266 20607 78802 106633 244585 12009 99100 103733 319845 22154 74470 21372 104318 109151 101565 110350 16328 17977 18763 18764 19017 260305 76779 16579 83922 17978 71492 59035 245866 81004 216363 66993 26370 17260 17261 70461 15183 20185 217166 74343 12914 382056 56406 11909 640703 75387 20656 21454 12462 22627 27373 12469 12461 12464 64436 18582 68146 227613 22153 22142 22145 12465 319757 670717 15278 21780 19088 208595 227112 17827 57423 68653 66477 76614 224904 11958 11957 68117 230935 216821 11947 66075 11949 433771 68055 68316 17705 11946 269951 15526 66098 66043 11950 53375 100041835 100039108 432676 64384 228033 75786 15519 18747 68097 51792 56455 16559 219103 76707 13589 18472 232987 170826 13427 13424 226153 50776 216151 381760 212541 20181 19013 26379 18181 14390 68346 14661 226169 100986 241113 12589 56350 77048 230376 69654 52906 60525 17274 18000 73668 67661 75296 53413 75465 15185 72421 224481 72140 106840 67344 67068 219072 11843 20336 56297 225659 107371 72938 53885 207911 76478 320299 329795 78177 16569 217935 27078 28135 214444 76816 108079 74019 217335 19079 54130 105504 108097 74682 211446 72569 18817 71820 381644 102058 109242 19082 67042 233649 73916 12789 382090 232944 231214 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.4 RNA Pol II CTD phosphorylation and interaction with CE 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 96%446728 Cell junction organization 233833 16451 20665 12388 232440 19089 12387 13200 13626 12550 319149 20586 20779 13858 15077 104836 13345 19303 12558 21417 52615 19646 26413 26417 21418 22325 13001 13000 100039026 17869 245688 18109 209462 18810 22160 16480 16452 22330 66357 109711 224619 66286 228839 18550 18553 69019 93759 226970 73341 56529 12476 12695 224912 56217 13017 13016 16456 20683 93742 56513 68794 20163 21754 170736 74202 57342 218952 16202 225341 12821 16412 330662 56198 140580 192176 77630 11492 239096 11797 12385 59058 110751 12564 15426 66624 16201 330914 20613 12552 57875 15227 11798 54721 99982 76687 228913 11727 217734 99011 11735 19645 22323 12330 20901 60611 16601 114142 12741 16600 53325 17246 16193 12555 93760 13430 12561 21762 22123 19179 21844 19181 19182 64945 67956 23996 71740 19184 105837 18033 58235 26440 19294 19166 94332 71908 19167 15220 60363 26441 54420 58187 26442 54419 69077 12738 66997 93737 23997 54725 56863 12737 56436 75677 17463 215654 57296 320873 20422 12565 24136 26445 241201 26446 12563 19172 53624 19173 12562 19175 12739 15376 19697 12740 19177 12560 12557 12554 26443 56492 26444 16195 22431 19170 621628 21423 18759 14694 192897 75339 66413 330222 192173 667035 56173 22190 239857 16403 242653 239931 59029 230738 18746 16194 67089 76007 56805 70247 58220 21406 237979 21885 58998 18554 227485 18417 227377 114141 16780 75234 16782 15267 319168 16774 319167 13040 13030 76850 239528 319186 319178 319183 319182 236511 319190 319176 319181 19353 20014 213988 103963 217351 214150 69038 13135 20583 14056 18717 17454 319169 57377 20848 625328 78303 319188 15270 433759 624153 15182 16430 14376 382522 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME%R-HSA-196791.9 Vitamin D (calciferol) metabolism 100043429 14725 22337 100017 13115 13081 19141 244209 59004 14473 65969 22196 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME%R-HSA-9636003.2 NEIL3-mediated resolution of ICLs 234258 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.4 Signal regulatory protein family interactions 15170 54353 19261 19229 668101 19247 16423 22177 23880 14083 DAG1 CORE M3 GLYCOSYLATIONS%REACTOME%R-HSA-8932505.1 DAG1 core M3 glycosylations 13138 215494 217734 74653 99011 97884 DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME%R-HSA-429914.4 Deadenylation-dependent mRNA decay 78893 13682 52846 13681 231464 108077 230594 234594 214290 218343 56422 68106 218693 69305 103135 72587 104625 228140 66362 109075 66583 27998 50783 72544 67678 50911 234699 69639 24127 72662 66094 66446 69125 18983 13209 227715 319618 74108 67207 70640 75901 78651 27756 353190 225929 66373 58184 75705 13684 66317 208643 53621 72068 232791 192170 18458 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-HSA-420092.5 Glucagon-type ligand receptors 14702 14696 14527 14526 381853 14607 14697 22354 22353 20287 14710 14699 66066 14700 22355 93896 14688 14708 14706 14704 11516 14695 14652 11517 14693 64337 14709 14701 14602 14601 DEFECTIVE APRT DISRUPTS ADENINE SALVAGE%REACTOME DATABASE ID RELEASE 96%9734195 Defective APRT disrupts adenine salvage 11821 DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.2 Defective NTHL1 substrate binding 18207 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME DATABASE ID RELEASE 96%4085023 Defective GFPT1 causes CMSTA1 14583 IKBA VARIANT LEADS TO EDA-ID%REACTOME DATABASE ID RELEASE 96%5603029 IkBA variant leads to EDA-ID 16151 18033 18035 19697 12675 16150 18034 IMPAIRED BRCA2 BINDING TO RAD51%REACTOME DATABASE ID RELEASE 96%9709570 Impaired BRCA2 binding to RAD51 12021 81601 327762 20422 19361 22427 19718 69263 15574 11920 12189 12190 235610 231724 237911 19355 225182 26909 235559 12144 68275 106344 72151 68240 19891 19367 19356 19360 17535 21975 27354 INHIBITION OF PKR%REACTOME%R-HSA-169131.8 Inhibition of PKR 19106 NEGATIVE REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764725 Negative Regulation of CDH1 Gene Transcription 232440 24136 13626 319149 20586 22431 21423 15077 13345 75339 192173 21417 52615 18746 19646 26413 76007 26417 56805 21406 21885 245688 15267 319168 319167 22160 319186 319178 319183 319182 20613 319190 319176 319181 228839 99982 93759 228913 20583 14056 319169 67956 625328 78303 319188 15270 433759 13017 13016 15220 15182 624153 382522 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME%R-HSA-163767.6 PP2A-mediated dephosphorylation of key metabolic factors 18639 19052 21770 19053 51792 73699 58805 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME DATABASE ID RELEASE 96%9665246 Resistance of ERBB2 KD mutants to neratinib 13866 59079 12539 15519 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250913.6 Positive epigenetic regulation of rRNA expression 216848 232440 319149 667501 107932 20019 15077 21340 21339 21341 64424 22130 75316 81898 66420 70333 69833 11461 66136 245841 20017 19646 234366 110052 17749 245688 100043714 93762 23942 22385 17192 15267 319168 319167 229542 319186 328572 319178 319183 319182 319190 319955 18432 110147 319176 21374 319181 56200 56637 116871 116870 20018 14534 20016 319169 18519 12417 625328 78303 319188 15270 433759 15182 624153 382522 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9630221 Defective NTHL1 substrate processing 18207 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME DATABASE ID RELEASE 96%8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 20459 11848 232906 140579 18176 218397 19353 12927 15461 330662 19303 12928 140580 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 96%417957 P2Y receptors 67168 574402 78826 74191 18441 78134 18442 233571 235036 140795 70839 57385 FRUCTOSE BIOSYNTHESIS%REACTOME%R-HSA-5652227.6 Fructose biosynthesis 20322 11677 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME DATABASE ID RELEASE 96%425407 SLC-mediated transmembrane transport 68267 117591 114479 114304 13340 269346 63959 11815 18174 53945 11416 19879 20521 28250 54403 20538 238384 26569 246787 22232 640703 23985 72027 13487 20501 104245 12215 20516 15203 28253 170441 71279 317750 12870 24059 20533 20505 142681 20531 100434 94249 213603 76376 30805 242259 108052 75750 27411 70129 226999 67473 68682 236794 67582 63993 331004 70840 77031 242126 236727 105243 277973 110895 20544 56327 69048 20537 20526 13162 18400 239436 11739 433923 11740 20519 20520 56636 216227 109552 170756 110891 70484 57138 20498 20499 20495 20497 20496 107723 20541 110893 22348 233836 228368 239606 53881 24060 268512 218756 231583 15567 232333 14412 242585 13521 243616 73836 114644 72621 320718 20518 74340 235504 20517 27376 338365 225579 330064 65221 18399 56643 83429 100561 230612 59033 243755 214922 20528 108652 106947 434203 57274 58807 80879 20525 94229 20503 240215 13723 20529 20500 353169 435818 171429 241612 30791 58246 14977 108115 237831 26457 72002 107566 20536 77701 20535 19729 11998 227394 64452 109342 67547 101488 55961 243328 208890 226781 18173 232156 22784 230810 214111 20515 13358 106957 20504 20502 22782 98396 72045 213053 227659 227059 212980 14664 140919 240332 229782 103098 53896 56774 242607 14411 30962 20532 215113 216225 67760 50934 209837 20513 21366 20514 215335 11989 234967 55963 69354 74338 76257 20511 20510 102680 20527 20512 20540 330836 72401 246049 17254 11987 56017 214663 105727 20539 26570 71803 67863 CTNNB1 T41 MUTANTS AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 96%5358752 CTNNB1 T41 mutants aren't phosphorylated 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 SCN4%REACTOME%R-HSA-3282872.4 SCN4 68401 ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559585 Oncogene Induced Senescence 17248 233833 15901 236511 20683 17246 211586 13555 19645 21781 12571 12567 213988 13557 13875 242705 217351 667035 214150 22190 100043858 12580 26413 26417 12579 12578 23872 23871 17454 22059 76850 REPLACEMENT OF PROTAMINES BY NUCLEOSOMES IN THE MALE PRONUCLEUS%REACTOME DATABASE ID RELEASE 96%9821993 Replacement of protamines by nucleosomes in the male pronucleus 319178 171506 319183 319182 74319 319190 319181 20815 625328 78303 319188 15260 15270 328440 319186 19119 382522 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.3 Cam-PDE 1 activation 640703 18575 18574 18573 NGF-STIMULATED TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9031628 NGF-stimulated transcription 21990 328572 56437 14066 20807 17095 20393 12570 15902 15901 17172 20408 15903 14282 14283 16478 211770 17936 13653 17937 107932 11838 13656 13712 13655 381677 15904 16477 17261 21406 11909 19712 13430 100040260 14281 12569 13654 12568 C6 DEAMINATION OF ADENOSINE%REACTOME%R-HSA-75102.4 C6 deamination of adenosine 56417 110532 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME DATABASE ID RELEASE 96%5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 13138 217734 99011 BACTERIAL INFECTION PATHWAYS%REACTOME%R-HSA-9824439.2 Bacterial Infection Pathways 12388 12387 58194 12550 20408 12402 56324 20779 15239 20404 17295 19720 20844 20405 13858 104836 667035 22190 19349 18126 26413 26417 71514 15519 55932 16211 14917 70686 26395 170761 26396 12527 50493 18571 12363 12010 17002 236573 15516 15129 109637 17075 15122 672511 12721 16646 26400 13806 26398 15200 18550 233405 100041766 108664 18655 640703 56216 20980 606496 64176 22317 271457 64051 22318 20614 13035 20979 20907 24088 75209 13629 14469 17533 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 96%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 13038 241196 12400 67296 13039 12702 DAG1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8931838 DAG1 glycosylations 216395 13138 75847 243853 98388 68273 67843 108902 215494 228366 217734 74653 24060 268510 246179 99011 16795 97884 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME%R-HSA-9005891.5 Loss of function of MECP2 in Rett syndrome 18747 81004 640703 20602 433759 12326 21372 56310 15183 20185 20466 ACYL CHAIN REMODELLING OF PG%REACTOME DATABASE ID RELEASE 96%1482925 Acyl chain remodelling of PG 18778 18783 226856 271844 18779 66586 237625 26971 99010 210992 26970 26565 18784 18782 78390 66350 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO RDH5 LOSS OF FUNCTION%REACTOME%R-HSA-9918438.1 Defective visual phototransduction due to RDH5 loss of function 19682 19771 TELOMERE MAINTENANCE%REACTOME%R-HSA-157579.7 Telomere Maintenance 232440 208084 14156 72171 245474 214987 22589 214901 20174 68964 72107 108689 69535 66181 12566 216853 68147 16881 13163 66420 69833 67710 52530 245841 21752 69920 20022 20020 18969 231329 18968 20021 69241 17749 19075 100043714 19076 28113 15267 101185 319168 319167 69745 319186 319178 319183 319182 327762 12428 269400 319190 22427 57321 19687 19718 319176 69263 319181 319152 56505 21749 497652 21750 18538 105522 12144 68275 106344 72151 18971 67857 68240 18972 19891 319169 12427 52036 67967 625328 78303 319188 15270 624153 382522 TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME%R-HSA-167246.4 Tat-mediated elongation of the HIV-1 transcript 68092 433702 20922 20833 68705 98053 13871 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 58202 17420 67923 12572 27224 13872 27632 20924 24116 23894 12455 14884 13716 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.3 Tandem pore domain halothane-inhibited K+ channel (THIK) 217826 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%198693 AKT phosphorylates targets in the nucleus 56484 54601 58988 56458 15370 23797 11651 11652 ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.4 ATF6 (ATF6-alpha) activates chaperones 270669 14828 226641 18044 18045 11911 12317 18046 13198 22027 56453 RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME%R-HSA-9948299.3 Ribosome-associated quality control 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 269523 100043755 66105 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 105083 68098 24015 67923 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 56436 17463 57296 75452 20422 77987 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 667035 22190 59029 67089 70247 217365 78913 213753 22230 66855 66244 76788 52231 100041766 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 216080 672214 66481 225058 71745 100038875 100038991 68028 100043000 67891 100043295 GBP-MEDIATED HOST DEFENSE%REACTOME DATABASE ID RELEASE 96%9953170 GBP-mediated host defense 110606 18712 229898 55932 18550 11465 12362 14272 11461 55948 14469 225467 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME%R-HSA-6785807.8 Interleukin-4 and Interleukin-13 signaling 16451 17161 12575 12443 11651 16153 16186 56468 21417 18126 15519 12491 17869 11799 15251 16189 16163 22352 22160 18708 16452 12609 15368 17395 18386 17392 20293 12702 14462 16190 83995 17984 16477 16165 16164 14086 19885 18413 15481 17210 16193 69581 15234 53314 56484 100038891 12043 16819 12048 257630 14103 11687 56458 20292 20674 14173 16364 20299 18390 16194 20210 19225 11689 16412 19883 16409 22329 22059 16776 16878 14128 21938 16411 14268 16160 16414 16176 16159 21926 14281 12053 22027 16803 12843 16173 16453 54721 18712 16175 20852 13609 16952 15894 18986 74145 16171 17390 209590 21857 20846 17829 21803 20848 18976 22339 12703 TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME%R-HSA-190827.4 Transport of connexins along the secretory pathway 14609 14619 14618 OLFACTORY SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 96%381753 Olfactory Signaling Pathway 258299 258381 258992 258486 258650 258487 257884 18367 258991 258736 258097 258794 52250 258857 259111 258836 258821 56858 258542 258405 258935 258420 258321 259036 259034 259119 18324 258697 258432 258675 258673 64337 258677 257905 258334 258025 667918 258832 258469 258882 258601 258853 259112 258657 18366 18328 258470 258600 258338 258455 259053 258027 56015 259041 258573 259049 258563 259013 117004 258846 258105 329460 258854 258930 258281 257962 258387 18314 259063 258896 404315 258453 257883 104111 258586 258869 258587 14688 668825 258363 80706 258362 257909 258575 258358 258658 258616 258941 258944 258618 18369 258216 258866 258580 258582 16825 228228 258160 258267 258350 258544 258772 258640 258608 259015 404329 259110 546747 258636 259109 258715 259014 16870 258395 259051 258680 259045 258155 259100 258154 258805 258147 257916 258572 258990 18313 258749 258340 18331 259097 258036 258355 404318 259047 258980 259004 258407 259017 259019 170639 258371 259113 258656 258562 436002 258424 258752 18365 258939 258961 258268 258305 100038859 100043474 259074 258507 258427 259122 257917 404346 258819 258672 259075 259040 259058 258746 57251 258614 258700 258694 258478 258443 258178 258222 258775 14680 258352 258248 258831 258196 258458 18315 258776 259054 404317 258720 258985 258690 258373 404222 18317 258717 258937 668035 259071 258292 258531 258756 258238 258710 259106 258322 258946 258975 258763 258325 258536 258925 258924 258706 404331 258302 258804 258713 239766 258270 258704 259147 18343 18310 258310 258303 259115 259012 258357 258347 259035 258296 258179 259066 258206 259095 259092 244187 258098 259089 258163 224055 258914 258319 258759 258609 257898 258287 258506 258922 258316 258354 18346 259002 258814 259067 258620 258207 18341 18357 18330 218066 258016 257972 29849 258729 545140 258769 257985 258075 258515 258439 258271 258408 13591 258153 18312 258481 258318 258275 404319 258151 258933 258039 18322 258908 258702 258703 258659 243634 233649 12789 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.5 Signaling by Hedgehog 81896 77583 21821 19087 19084 269523 68525 16568 18747 59056 213081 74239 104346 230500 20747 237222 74126 66313 109689 216869 380718 106633 244585 110350 103978 245866 214498 21762 22123 14634 14633 19179 19181 19182 23996 19184 75788 26440 19166 19167 26441 26442 69077 66997 23997 12234 93687 56436 17463 57296 20422 26445 26446 19172 11491 19173 19175 19177 21402 56438 26443 26444 19170 66413 19206 26965 667035 22190 59029 67089 70247 110355 20423 16396 13363 22158 319757 70300 271639 240888 14632 380614 66573 214240 71742 19088 226861 76857 18453 216440 104110 73668 67661 56637 432530 210044 104111 66753 16147 26554 116891 20338 14451 224129 57810 15245 11512 117606 11513 11514 18222 11515 18749 74682 24069 73916 19085 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.3 Purinergic signaling in leishmaniasis infection 15368 16173 66824 216799 19697 69146 12495 12499 18034 12267 16175 19200 54483 12266 18438 16176 12362 18033 18439 22166 67955 56338 13035 23959 15516 HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 96%1483115 Hydrolysis of LPC 74182 192654 232889 18783 329502 66857 78390 271844 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375276.10 Peptide ligand-binding receptors 12767 17202 17201 22044 22045 13617 13615 246691 16963 208188 229214 140498 56183 212108 19773 242093 58182 381489 239336 104443 16336 224065 23919 319239 14289 14419 12772 12774 12768 80901 225642 56744 20607 59289 12776 14829 12775 12458 21333 12773 11606 12771 11607 12061 18386 12062 18389 23925 216749 21338 14064 20293 14063 14427 14062 14061 18166 21337 23832 18167 21334 18168 21336 14294 12424 14293 12425 12426 217369 227717 14065 12765 227288 280287 24111 56838 100043254 237362 385643 433292 246313 19156 20605 19065 20606 50501 19064 67405 211578 18216 54615 12145 12209 20609 20608 114229 14428 15171 13051 110312 18217 217212 387285 208990 230777 14767 22439 68039 18101 11820 57349 17171 30878 623503 107522 17329 20290 18429 17200 11998 18155 18430 55985 54140 20303 26361 109648 20304 12000 20306 20296 20292 20302 20295 20297 100039973 100038965 20299 56066 18387 20311 18390 20312 20300 18610 20210 18619 15139 252837 66102 12266 330122 20310 14825 14429 11609 23796 319430 12777 226278 12766 226304 12778 381073 12273 75805 76854 12769 15199 230857 14763 54199 12267 20604 171469 12854 13349 16952 15945 207911 13616 13614 18976 17199 13618 20315 17203 CHL1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447041 CHL1 interactions 53870 213119 109700 16398 12661 11733 16412 18186 15481 MITOTIC G2-G2 M PHASES%REACTOME DATABASE ID RELEASE 96%453274 Mitotic G2-G2 M phases 20873 68121 56299 29870 12534 78887 12575 217653 13555 22628 100038822 225745 231123 12566 74360 13557 18536 56371 66296 214552 19646 18541 75786 15519 18747 21664 71909 237222 73699 17997 18005 19052 73738 19053 68475 51792 53598 208518 236266 15516 328572 12009 99100 103733 22154 12428 74470 104318 56455 101565 16328 219103 108000 259279 103573 83922 171567 51885 72415 26370 76789 72083 76707 233276 103768 74237 13589 18472 12427 21762 12442 22123 19179 19181 19182 23996 19184 26440 19166 13427 19167 22627 26441 17931 22390 13424 26442 17865 72568 69077 66997 12530 231506 23997 12531 27373 629959 12234 56436 12532 17463 75660 57296 20422 26445 26446 19172 15366 19173 19175 268930 19177 21402 56438 26443 26444 227613 19170 72119 22153 66413 26965 667035 22190 22142 59029 67089 103583 70247 66671 17420 22145 12572 22059 14235 100986 16475 19088 230376 69654 231863 71648 17274 75296 72590 30949 77011 72486 19046 12537 77744 219072 225659 76478 78177 28135 214444 71978 76816 20878 54130 18817 381644 448987 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 96%418457 cGMP effects 58802 242202 23984 241489 18585 17540 18574 18573 72413 207728 16531 16533 19092 435726 16438 DAG1 CORE M1 GLYCOSYLATIONS%REACTOME DATABASE ID RELEASE 96%8932506 DAG1 core M1 glycosylations 13138 217734 68273 99011 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.4 Ub-specific processing proteases 319651 224836 56208 14479 107260 56324 84092 72607 15239 68031 21951 74493 22217 27401 170707 12005 235441 101206 22334 22333 22335 17869 217057 15925 327799 17125 15251 12638 17126 17127 84585 17128 100683 66313 109689 12006 17131 216869 76800 17248 30940 12428 17246 101565 22225 22284 14462 22224 107995 216185 21812 56505 68350 77125 28185 100043869 14534 12427 107986 71586 21762 230073 22123 108645 19179 19181 19182 23996 19184 19671 436004 26440 19166 18035 19167 26441 26442 69077 66997 12530 23997 56436 17463 57296 20422 26445 11555 26446 19172 19173 19175 19177 26443 26444 16151 100756 19170 66413 53376 667035 19211 22190 59029 26409 67089 24110 70247 269582 74270 71472 11835 22059 83563 66889 74112 30941 59025 216825 621893 22258 319162 15267 319173 74256 319163 319168 319167 319186 19766 11797 54198 319178 22230 319183 319182 14232 54601 22030 246103 69641 18970 319190 11796 319176 319181 66513 22034 59040 71954 50868 252870 319169 78303 319188 170822 235323 319189 74996 20439 382522 67561 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.5 ABC transporters in lipid homeostasis 217262 192663 217265 56535 26874 11806 11307 67470 27409 27410 11666 19298 74591 19299 27403 11305 76184 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.4 Defective SLC12A3 causes Gitelman syndrome (GS) 20497 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME DATABASE ID RELEASE 96%6807505 RNA polymerase II transcribes snRNA genes 69917 93697 68991 192657 69882 72656 231571 20683 218333 71957 101861 70885 71793 225283 57432 70470 68705 98053 66420 56698 69833 67710 227644 245841 69920 77634 20022 20841 102209 330959 75627 20020 231329 20021 69241 17749 100043714 12572 20924 68092 21374 433702 20922 108143 68776 99730 107951 18986 21343 226182 12454 229906 235459 83602 68153 74197 12455 83701 72949 13716 63856 229543 70422 109077 68510 71177 18987 210925 109019 18130 75137 77065 269344 REGULATED PROTEOLYSIS OF P75NTR%REACTOME DATABASE ID RELEASE 96%193692 Regulated proteolysis of p75NTR 100042305 208117 18053 59287 18033 100039623 11491 19697 22034 19164 19165 SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111469 SMAC, XIAP-regulated apoptotic response 12367 670717 11783 66593 12371 11798 12369 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.5 Assembly of active LPL and LIPC lipase complexes 56636 624219 270669 30924 15450 68453 76483 57875 11813 105847 208677 16956 18552 18550 66113 18553 11808 56453 EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME%R-HSA-9009391.5 Extra-nuclear estrogen signaling 18762 268980 20779 12443 11651 12389 11652 14697 18710 13610 14710 14699 12576 13983 66066 14700 26413 26417 15519 14708 14706 14704 13982 13649 14695 21802 14693 18176 64337 14709 15461 14701 20698 14281 18708 18709 18706 18607 14702 20807 17395 14696 17392 18127 12223 16589 71920 103573 13874 13712 15200 14678 14677 14679 14688 640703 17390 15469 14083 56484 16001 68268 12390 11839 17393 12043 102193 13645 23797 242851 TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 96%9013973 TICAM1-dependent activation of IRF3 IRF7 54123 56480 54131 667035 22190 22031 56489 106759 21353 142980 71648 MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.8 mRNA 3'-end processing 54196 15381 19655 269061 70616 68598 67959 20462 107701 68092 72047 74326 67500 433702 75956 64340 622469 225027 67996 225160 22608 51796 192160 331401 212880 71713 53817 233073 83486 625193 69823 20382 110809 23983 73666 18521 60365 83701 20383 68278 68479 70579 21681 73826 68134 66231 20222 66511 107829 66899 108014 192170 69207 19826 193116 66441 386612 17149 100040029 319322 19205 27967 107686 76936 384091 666609 24128 216578 68981 20639 229279 68705 20641 98053 667035 101943 20638 22190 81898 66420 69833 67710 20646 245841 69920 67332 20022 20020 231329 20021 69241 17749 100043714 15382 170791 53379 20630 56258 14105 59013 20637 98758 53607 11991 70044 56070 67039 72459 56194 15388 100336 15387 52040 66055 67465 236732 19045 67958 76479 19046 13211 75062 13204 51810 76938 13207 233908 66125 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 74320 68188 54188 ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9034864 Activated NTRK3 signals through RAS 15461 18213 18205 18176 20662 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME DATABASE ID RELEASE 96%9636249 Inhibition of nitric oxide production 16211 18126 16646 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME DATABASE ID RELEASE 96%380108 Chemokine receptors bind chemokines 17329 20290 55985 12767 20303 20304 20306 20296 20292 20302 20295 20297 100039973 100038965 20299 56066 20311 20312 20300 252837 66102 330122 16963 20310 14825 12777 12772 12768 12774 80901 56744 12766 59289 12776 12775 12458 12778 12773 12771 12769 20293 54199 23832 15945 12765 227288 56838 12145 13051 20315 57349 ANDROGEN BIOSYNTHESIS%REACTOME%R-HSA-193048.5 Androgen biosynthesis 15487 56348 18976 12640 57357 94224 15492 13074 15497 78925 16866 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 96%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 13138 217734 99011 DEFECTS OF PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-9823587.3 Defects of platelet adhesion to exposed collagen 14723 279028 14724 54368 14729 22371 VITAMIN B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.4 Vitamin B6 activation to pyridoxal phosphate 11761 103711 216134 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.3 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 13077 LOSS-OF-FUNCTION MUTATIONS IN DLD CAUSE MSUD3 DLDD%REACTOME%R-HSA-9907570.1 Loss-of-function mutations in DLD cause MSUD3 DLDD 12040 13171 13382 12039 REGULATION OF THYROID HORMONE ACTIVITY%REACTOME DATABASE ID RELEASE 96%350864 Regulation of thyroid hormone activity 107585 13371 13370 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 96%171319 Telomere Extension By Telomerase 67857 208084 245474 72171 269400 12428 20174 12427 52036 57321 66181 12566 28113 216853 101185 56505 68147 21749 497652 21750 52530 21752 105522 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME%R-HSA-5693571.3 Nonhomologous End-Joining (NHEJ) 12021 319178 319183 319182 81601 319190 19090 70620 319181 11920 12189 319152 22596 14375 93765 107823 68251 20184 240087 70681 70238 27223 107976 210766 55982 51869 59004 56626 56196 108138 78303 75570 15204 319188 104884 15270 319583 227525 19360 54125 17535 319186 27354 382522 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.3 Suppression of autophagy 70686 19349 GASTRULATION%REACTOME%R-HSA-9758941.6 Gastrulation 21415 12387 12767 12550 16842 270118 18121 14182 21418 22601 21420 21419 94093 17126 17127 17128 103806 13395 23967 328572 17300 14234 21414 12159 21416 16869 18504 333639 22772 14463 18510 12914 14534 21762 22123 19179 19181 19182 23996 19184 19664 18999 26440 19166 100038891 19167 17863 26441 26442 69077 66997 23997 56436 13388 17463 57296 14472 18508 20422 24136 26445 225207 26446 18991 19172 18424 19173 20664 19175 14179 15376 21389 19177 18128 20674 14175 26443 14173 26444 19170 66413 59029 67089 70247 14106 20423 21679 21677 20613 13813 20671 20997 15227 14836 27217 14465 227606 22416 384452 17701 18509 84653 56184 17293 13389 16147 15375 18505 13838 18519 16848 22771 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME%R-HSA-76071.4 RNA Polymerase III Transcription Initiation From Type 3 Promoter 21374 67065 74414 66420 69833 227644 78929 245841 66653 544971 77634 20841 18986 102209 26939 330959 67486 75627 70408 20018 69870 70428 17749 218832 100043714 67005 20016 12909 REGULATION OF ENDOGENOUS RETROELEMENTS%REACTOME%R-HSA-9842860.2 Regulation of endogenous retroelements 216848 232440 319149 67155 20586 20588 20587 107932 70127 29861 269397 15077 243834 19708 232854 75339 67010 432769 268996 70650 12055 12054 11461 77045 21408 223828 19646 234366 12419 330890 72198 13435 21849 245688 22196 54343 100043429 23942 68094 17192 83796 77683 15267 83797 57376 319168 233060 431706 319167 244713 84505 229542 319186 434178 319178 319183 319182 319190 110147 239985 319176 74522 56456 319181 66993 116871 116870 93760 319169 237758 625328 54427 78303 100039610 319188 622480 15270 433759 15182 624153 382522 SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 96%9703465 Signaling by FLT3 fusion proteins 14389 224139 12575 20742 18176 20662 20851 20850 15461 18712 50490 109181 360013 14011 18708 76007 18706 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 96%397014 Muscle contraction 235281 269717 11931 14226 20266 11932 20265 11933 11937 11938 65973 53313 109305 11472 56188 76757 16514 56461 109552 67972 20271 11941 18160 399548 320707 230103 20272 381290 53419 20274 13405 12322 18159 20273 12323 19303 108058 97064 110876 12325 20192 20269 20191 72821 20866 110880 110891 20190 229709 16438 16439 13400 20264 18747 11928 67268 98660 232975 20541 57780 18125 11474 110893 21925 16440 21393 59095 50876 20928 21957 108017 233199 21954 17868 50875 50874 13346 17883 21956 17888 109272 21894 17885 17996 21924 21916 22352 21953 21952 21955 17901 17906 18479 17897 17896 54378 22330 12288 14169 15257 14168 14167 14166 56808 242202 12295 12296 70357 80334 16520 14463 16518 15258 640703 16515 54377 81905 16529 210741 241769 16526 16527 223604 16535 21388 18091 22063 74571 109700 72258 16528 230899 104158 16506 16493 16508 17380 56543 217826 16511 211480 332396 224105 17907 100986 216459 58226 12291 52150 239556 16525 11749 16530 67938 17904 107589 22004 434246 20410 26903 93689 17880 17898 54195 60596 59310 12391 16419 20411 22138 59069 234889 16952 11669 81904 18519 57814 246133 66240 12306 16509 57442 24046 LOSS-OF-FUNCTION MUTATIONS IN DBT CAUSE MSUD2%REACTOME%R-HSA-9865113.1 Loss-of-function mutations in DBT cause MSUD2 12040 13171 13382 12039 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME DATABASE ID RELEASE 96%8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 233833 213988 236511 217351 17454 214150 76850 239528 RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9035034 RHOF GTPase cycle 54004 109711 223666 83397 14270 330914 207495 208263 71435 70350 228359 13367 12389 268301 22319 20619 11855 223870 11461 19349 68428 66898 229658 12345 23943 27360 75415 53332 218581 84004 16906 21917 17925 18708 71709 223254 18709 218756 56419 23912 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-HSA-9734009.2 Defective Intrinsic Pathway for Apoptosis 14103 12532 12380 12333 12261 22059 12334 12336 20656 56484 16476 69543 18477 21672 16906 22627 12569 12568 11820 99412 12125 12530 12578 12531 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME DATABASE ID RELEASE 96%3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 234130 73016 84035 56811 24117 74499 20319 20377 22416 22418 22417 216795 16974 13380 16973 MITOCHONDRIAL PROTEIN IMPORT%REACTOME%R-HSA-1268020.6 Mitochondrial protein import 67892 636544 67264 66865 14297 22333 66821 100900 66445 73078 15510 18416 11739 11740 11692 69617 103172 66826 66531 66525 52815 56322 433806 100042179 17827 17714 68653 66433 66169 15929 28185 100043869 67105 21855 30059 71883 11947 14356 66075 30055 68185 11429 11946 53333 15526 68033 12856 30057 53375 21856 100041835 30056 66119 100039174 30058 66170 223696 78830 12974 50799 72170 17713 67713 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.4 Vesicle-mediated transport 193813 270160 12068 70785 317717 235633 56494 192232 60409 211922 89867 67443 225870 58194 235416 329260 216131 69440 20408 67231 19328 12402 66890 12663 56324 217449 15239 20404 20844 20405 13858 12874 56044 117197 245638 27059 18457 224139 94245 80912 11777 170760 54401 20615 21987 232946 20661 77929 67804 69178 12848 17920 109689 216869 100043806 26891 15129 15122 56444 67665 22428 11806 13191 12121 76895 12344 238055 18476 59288 18475 105785 22365 64930 18002 14325 640703 22084 216705 14319 20980 18477 22041 22318 22627 20979 11820 99412 22042 26934 11555 12282 66397 69608 218811 320634 99683 20619 243764 77371 20334 56447 54161 12827 12826 12825 66371 68953 75608 208092 12836 66700 59042 100017 76877 17918 56395 14366 76709 73178 22418 105513 11771 11772 11650 71770 434174 56443 68137 11657 66913 68089 67771 56378 66713 232910 74117 11773 16835 50797 70349 12847 13543 16971 17913 54160 108148 66111 54399 75612 217615 192188 104015 73470 16563 234663 12491 20288 117158 77980 140792 71145 213827 17167 380713 11844 53334 68097 73804 14269 67511 56358 214459 14799 56455 26951 229841 75985 68938 228850 19325 68328 18472 57915 20528 210789 68365 74741 235661 18195 110379 13427 11839 19157 13426 13645 67474 19159 13424 19158 228421 72318 27277 73124 11998 12000 11699 15458 15439 16069 21872 240641 269152 16565 16564 16552 11891 16580 16581 67023 16561 16562 72772 16558 20210 70218 20932 75050 16554 286942 71116 16578 319991 224630 16560 11774 26754 241113 69654 71648 17274 19353 53413 11843 20336 107371 16569 68449 108079 381605 67046 19079 54130 100855 14423 105504 19341 108097 56486 211446 108995 77407 19337 269589 102058 74105 224617 19082 260302 235442 233204 17158 56715 103724 23797 19338 209815 93739 28169 22241 54189 227800 69940 66687 207592 16570 19326 70296 107338 106039 22628 215114 11651 66482 11652 53357 338366 93671 17886 109181 107305 72543 27681 70160 194309 52348 116733 73711 16568 22088 67123 330192 28084 76959 53869 66201 13649 20479 12500 21802 66914 55948 12502 12638 11801 269855 12504 53598 108099 104318 16594 668303 16579 232943 19348 216363 71819 16593 16551 110033 13047 209737 20202 74764 76932 73296 108123 108124 16004 74375 76332 16834 14609 226089 14619 76688 270192 19345 53611 271457 56367 19344 319642 102339 19346 98910 58244 70646 78304 338337 104303 17957 67542 78689 242406 56382 53330 228960 69834 224705 76899 245944 97484 68505 233824 54214 12662 232286 68299 22319 227746 70297 19349 56418 192187 70361 100039786 16572 66251 16573 16443 56389 66905 14615 14610 14617 20909 12343 12345 11842 12340 16571 319934 67300 13429 12757 20739 20740 74947 11733 11735 640524 20742 12317 20741 20743 11816 103967 80297 15519 15505 19339 11607 12223 71920 13874 20508 15200 21336 22320 26893 17113 14533 13423 11840 74325 26894 15481 67489 20955 11766 108679 11781 108011 215890 74438 105245 64138 13430 11782 26572 72685 26895 16334 74018 667035 22190 18783 110355 77038 11768 11769 108012 22027 11764 11765 11767 252903 12843 12842 14618 71693 20912 13132 13043 73094 229521 194590 210108 233489 80718 218503 30931 228998 18704 30934 14621 74015 225152 13854 353155 66691 17155 14613 67091 108800 17156 14612 20703 80708 230815 14611 66226 66616 14622 19324 240028 20616 14620 105522 20403 14616 243819 13855 14623 14067 231580 118454 69162 11845 75964 14275 67602 270096 12793 15463 217835 67857 18717 14569 100042773 29816 66975 20333 56017 14567 215474 218038 72433 207352 30948 227801 74498 13859 102442 22631 66682 320129 76954 52036 12492 106572 22629 76983 60510 19347 13032 269774 229541 245828 23969 72121 12794 20975 67790 240667 106628 72825 67727 14725 320714 214895 16197 216344 59005 55925 67844 14069 66147 20692 74760 78232 23970 245886 56041 170625 320560 333883 54609 329727 21787 56085 320435 27096 226407 72978 105841 227648 19330 76308 74030 76510 329877 100042343 209773 50907 192236 ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.6 Activation of the pre-replicative complex 27214 67177 23834 59001 57441 70024 17216 17215 17217 17218 17219 17220 12566 66979 12544 50793 18392 18393 66634 26428 26429 56452 12545 68275 18969 18968 68240 19075 19076 19891 18973 18974 TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME DATABASE ID RELEASE 96%5250958 Toxicity of botulinum toxin type B (botB) 20980 22318 20979 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 96%1614603 Cysteine formation from homocysteine 12411 107869 DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 96%5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 103988 103468 19386 231103 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 SIGNALING BY LRP5 MUTANTS%REACTOME%R-HSA-5339717.5 Signaling by LRP5 mutants 234130 73016 84035 56811 13380 16973 COMPLEMENT CASCADE%REACTOME%R-HSA-166658.6 Complement cascade 317677 71756 14134 12759 12630 17195 93721 12944 12273 11537 12274 16904 545366 12259 17221 71693 56373 12260 12902 12262 109828 12267 50701 14061 15139 14962 12263 12266 625018 22370 230558 333883 19128 319430 12258 110382 12478 12520 69379 12279 667277 50702 239447 12628 DNA STRAND ELONGATION%REACTOME DATABASE ID RELEASE 96%69190 DNA strand elongation 327762 14156 109145 17216 272551 17215 19687 17217 19718 17218 69263 17219 17220 78833 12544 69270 66634 16881 18538 68275 18969 106344 18968 72151 18971 68240 18972 19075 19076 19891 67967 69745 TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME%R-HSA-918233.4 TRAF3-dependent IRF activation pathway 328572 12914 56480 54131 15977 22031 56489 71586 230073 66641 71956 228607 217069 54123 DEFECTIVE B3GALTL CAUSES PPS%REACTOME%R-HSA-5083635.4 Defective B3GALTL causes PpS 66548 330267 207596 224697 56229 239337 77794 279028 108153 23794 30806 108154 210417 271127 229595 208936 77739 381694 269959 100689 233744 235130 240322 20357 11504 20356 18636 21826 226866 21825 240913 223838 237360 330119 216725 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME DATABASE ID RELEASE 96%450282 MAPK targets Nuclear events mediated by MAP kinases 21770 73086 13712 26420 26414 17260 26416 17258 23939 26413 26417 20111 11909 19094 26419 73699 110651 20112 100040260 101568 235584 17164 67603 19052 319520 16476 72349 19053 51792 14281 TRANSPORT OF RCBL WITHIN THE BODY%REACTOME%R-HSA-9758890.2 Transport of RCbl within the body 14725 100017 17250 54219 19300 68421 21452 MUCOPOLYSACCHARIDOSES%REACTOME%R-HSA-2206281.5 Mucopolysaccharidoses 50917 27029 11881 15931 52120 110006 15586 27419 75612 15932 12091 DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.4 Defective TPMT causes TPMT deficiency 22017 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 20181 12012 20186 13123 93732 104086 17977 13122 77337 208665 101502 83702 13124 17978 26459 26458 15488 17117 170789 105349 27413 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%R-HSA-2474795.5 Diseases associated with visual transduction 242864 77974 79235 14539 19659 12057 22139 19682 11304 19771 20897 19662 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 96%1227990 Signaling by ERBB2 in Cancer 13866 59079 12539 13649 18183 83961 100042150 12223 18176 14388 20662 13874 15461 15200 211323 18803 19248 13645 18708 18706 20416 15519 THREONINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%8849175 Threonine catabolism 15473 257635 231691 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME%R-HSA-1362277.3 Transcription of E2F targets under negative control by DREAM complex 13559 75660 104394 17187 23834 17869 211586 13555 21781 21973 433759 19650 19651 18538 19646 72568 12530 231506 629959 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-HSA-170670.5 Adenylate cyclase inhibitory pathway 14680 224129 11512 11513 11514 11515 104110 14678 14677 14679 432530 210044 104111 242851 TRANSLATION%REACTOME DATABASE ID RELEASE 96%72766 Translation 67895 13200 107508 269523 64658 66419 64660 78523 94061 623346 102060 50529 233870 100040519 68565 99045 66973 69163 20818 52443 107513 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 66286 232536 56280 66493 353242 67681 66399 64655 107733 68537 18100 67398 67707 94066 60441 218506 66230 68098 68463 65111 75705 74600 107734 69019 66242 13685 28028 13684 68735 622268 27398 94067 208643 28030 67840 68836 217869 79044 226982 94065 57312 67923 75398 68572 56529 67308 64659 56282 66292 24030 66121 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 56438 17711 217365 22230 66624 20226 57743 76687 53421 27207 100043039 67097 670832 66212 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 17705 20102 20103 668668 14853 667739 672214 66481 71745 225058 100038875 100038991 225363 68028 100043000 67891 18458 100043295 622534 14852 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 66105 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 66256 100040970 20832 267019 67437 56040 66661 67248 217337 100040331 24067 67941 27058 66384 20813 72265 57294 70316 108853 211253 320806 17721 17722 17716 17717 17718 17719 17720 105083 67871 24015 21762 67768 22123 67674 19179 19181 19182 23996 19184 26440 19166 19167 71941 70120 26441 381314 13629 67417 26442 67160 102436 69077 66656 74776 66997 55949 109093 23997 13628 212679 70560 56436 71984 17463 224805 57296 353172 75452 20422 70791 77987 26445 68915 26446 230577 19172 226539 19173 71807 19175 69955 244141 13682 19177 13681 27979 56347 26443 13669 26444 53356 68135 19170 55944 66085 73830 66413 16341 223691 667035 22384 22190 54709 100042807 98221 59029 66235 67089 70247 17708 17709 17710 13665 67204 108067 217715 26905 13667 209354 224045 78913 213753 66855 66244 76788 52231 20014 103963 100041766 107045 226414 97541 235606 239555 22375 216443 234734 107271 69606 27267 23874 105148 76784 70223 231872 76366 67851 66143 15115 110960 66590 22321 216080 104458 85305 13722 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME%R-HSA-176187.4 Activation of ATR in response to replication stress 12532 27214 23834 70024 17216 17215 17217 19718 17218 69263 17219 15574 17220 12566 12544 50793 18392 18393 235610 66634 231724 26428 26429 19355 56452 269582 12545 68275 106344 72151 68240 19891 19367 19356 12649 12530 PHOSPHORYLATION AND NUCLEAR TRANSLOCATION OF THE CRY:PER:KINASE COMPLEX%REACTOME%R-HSA-9931530.2 Phosphorylation and nuclear translocation of the CRY:PER:kinase complex 12952 13001 13000 100039026 19047 104318 19045 19046 12568 18626 18627 18628 12953 27373 SIGNALING BY VEGF%REACTOME%R-HSA-194138.4 Signaling by VEGF 17973 12388 12387 76884 18186 11651 12389 11652 22324 19303 26416 12928 216148 229709 14360 16438 29857 16439 15519 18747 22325 15507 19094 102626 16440 26415 57257 18176 19877 16416 15461 17164 78757 228775 19878 16480 18708 18709 18479 18706 18607 74769 18127 27371 230126 18481 19229 640703 14254 18803 16542 50884 83767 26362 329165 18762 11848 105855 242687 12562 17969 11308 13058 13057 108100 18751 18654 17970 101314 17972 18753 140579 330662 20698 224105 140580 75778 227290 20430 12385 56717 19353 12927 227743 14205 109270 245880 16410 218397 18749 14083 17974 18187 14257 22341 22339 22340 56716 18750 23797 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 96%888590 GABA synthesis, release, reuptake and degradation 232333 14412 14411 243616 268860 14415 14417 22348 214579 19339 13002 22318 20614 20979 20907 12889 15481 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702605 pexidartinib-resistant FLT3 mutants 14255 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME%R-HSA-9022537.2 Loss of MECP2 binding ability to the NCoR SMRT complex 81004 20602 21372 56310 15183 20185 BICARBONATE TRANSPORTERS%REACTOME%R-HSA-425381.4 Bicarbonate transporters 20536 74340 20535 232156 20533 94229 240215 218756 59033 54403 DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-HSA-168928.12 DDX58 IFIH1-mediated induction of interferon-alpha beta 56480 74153 54131 19697 53323 100038882 16150 67526 11793 16151 66105 667035 225913 22190 20203 20210 54644 15519 26401 69721 270151 11596 71966 74256 21929 16396 12370 15516 19766 328572 56791 23988 22030 22031 56489 21353 18034 54123 434174 100041766 14082 22034 12914 28185 15977 71586 230073 66641 12675 18521 52440 71956 228607 217069 18033 216080 80861 18035 108086 18036 11820 FCERI MEDIATED MAPK ACTIVATION%REACTOME%R-HSA-2871796.4 FCERI mediated MAPK activation 234779 26400 26398 19353 22324 26420 26414 20963 26413 26417 22325 26401 26419 57257 17096 18176 20662 15461 17444 16476 18803 14281 224105 16822 18479 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.5 SUMOylation of SUMOylation proteins 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 106021 103468 19386 234865 59004 59015 22196 69736 100043429 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 96%380994 ATF4 activates genes in response to endoplasmic reticulum stress 72544 50911 69639 72662 64209 66446 227715 74108 70640 18044 11911 18045 18046 20293 12611 16006 226641 11910 12608 13198 66362 109075 66583 27998 27053 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME%R-HSA-168271.5 Transport of Ribonucleoproteins into the Host Nucleus 18141 107939 69482 71805 54563 16646 19069 70699 72787 18226 218210 69912 16211 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 MATERNAL TO ZYGOTIC TRANSITION (MZT)%REACTOME DATABASE ID RELEASE 96%9816359 Maternal to zygotic transition (MZT) 78893 232440 319149 13682 52846 13681 192119 15077 231464 75605 100043167 230594 234594 547035 214290 22601 218693 22059 54196 21679 15267 15260 319168 104625 319167 228140 239528 328440 319186 19119 171506 328572 319178 319183 319182 69125 18983 319190 319176 319181 58184 208718 75705 216850 13684 12914 75467 208643 194388 18140 214899 74319 11628 319169 22289 56057 12193 382035 20815 53621 625328 78303 72068 319188 15270 232791 192170 624153 382522 18458 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME%R-HSA-936440.6 Negative regulators of RIG-I MDA5 signaling 56791 23988 56480 54131 74153 22031 56489 53323 100038882 67526 11793 66105 667035 100041766 22190 54644 270151 71586 230073 18521 71956 52440 228607 217069 74256 216080 21929 108086 16396 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.2 TP53 Regulates Transcription of Caspase Activators and Caspases 12366 22062 268973 11783 12362 12368 12905 22059 57913 11920 22061 FOLDING OF ACTIN BY CCT TRIC%REACTOME%R-HSA-390450.5 Folding of actin by CCT TriC 12469 12461 12466 12464 21454 12462 11461 12465 12467 12468 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 96%194441 Non-coding RNA Metabolism 18141 107939 69482 71805 54563 107686 384091 19069 666609 68092 216766 70699 66069 621705 72787 20595 433702 18226 66603 218210 53975 12729 276919 20641 27374 20638 56698 70465 69731 432803 67332 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 RSV-HOST INTERACTIONS%REACTOME DATABASE ID RELEASE 96%9833110 RSV-host interactions 16451 56208 54131 23989 20933 56438 100038882 170786 27061 59024 327987 667035 22190 70625 68975 234959 75613 381379 15529 11603 94112 23806 23888 20971 28077 70208 67219 170779 21899 19106 20969 171285 71951 20970 56771 80509 170743 14735 67224 19014 264064 142980 66999 76199 319186 328572 17087 56791 67279 15530 12475 17755 103978 54721 20847 69790 21898 14733 26896 15975 216154 246728 12914 51813 108098 15977 14734 67923 71586 69792 75717 230073 228607 217069 67381 13051 66172 192191 24088 78334 FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.3 FGFR2 alternative splicing 19205 76936 68092 433702 68705 98053 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 15382 59013 98758 93686 77411 21843 21841 FORMATION OF THE EMBRYONIC STEM CELL BAF (ESBAF) COMPLEX%REACTOME%R-HSA-9933946.1 Formation of the embryonic stem cell BAF (esBAF) complex 93760 20586 20588 20587 56456 14025 68094 83796 19708 66993 83797 268996 57376 12055 12054 11461 77045 72057 58208 FORMATION OF THE CANONICAL BAF (CBAF) COMPLEX%REACTOME%R-HSA-9933937.1 Formation of the canonical BAF (cBAF) complex 93760 67155 239985 20586 20588 20587 70127 56456 29861 269397 19708 83797 268996 57376 12055 12054 11461 77045 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 96%73863 RNA Polymerase I Transcription Termination 19285 667501 21374 21429 20019 21340 21339 21341 64424 22130 13871 75316 66420 70333 69833 66136 245841 20017 14885 209357 66467 20018 66671 17749 100043714 20016 17420 12572 13872 23894 14884 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.3 Signaling by moderate kinase activity BRAF mutants 16706 20779 12322 109880 12323 108058 12325 26413 26417 12988 109905 640703 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 16653 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 O-LINKED GLYCOSYLATION%REACTOME%R-HSA-5173105.10 O-linked glycosylation 71685 66548 13138 26887 330267 14426 207596 20448 108148 224697 171212 105450 56229 232984 353328 108105 239337 241391 68273 207839 77794 72297 233733 94192 108150 279028 212996 97440 654821 72077 271786 14537 67909 108902 74653 73068 216395 75847 21825 24060 243853 140703 171167 56336 56386 231727 268510 97884 227327 53625 80294 108153 70945 23794 30806 108154 16795 210417 271127 229595 208936 77739 381694 269959 14425 269328 98388 230145 100689 233744 235130 240322 20357 11504 20356 17829 18636 14423 67843 100039649 21826 140474 224116 215494 226866 228366 217734 20446 17063 20444 59048 20442 246179 240913 20443 272411 223838 231050 99011 78754 237360 20440 333424 330119 210004 216725 108760 73732 20447 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 96%9026519 Activated NTRK2 signals through RAS 18212 15461 78405 12064 18176 20662 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 96%379716 Cytosolic tRNA aminoacylation 67895 353172 107045 226414 97541 216443 107508 22375 20226 234734 107271 27267 105148 23874 231872 70223 66143 15115 110960 66590 22321 104458 85305 13722 NEUTROPHIL DEGRANULATION%REACTOME DATABASE ID RELEASE 96%6798695 Neutrophil degranulation 53381 70450 12654 13014 102595 170813 14190 12796 76905 67912 53328 74244 71728 76025 229574 12508 12514 78892 68724 26949 232413 27261 433375 235627 26416 19074 19271 19263 72461 18103 17523 70152 26413 52633 217353 19276 69981 59026 667301 231887 109905 72042 69660 71869 72065 394252 100042069 78388 21946 23917 16970 227960 67689 18176 74287 29875 223978 19877 100037283 11571 208795 380924 13169 245126 20568 383295 215449 241197 67213 18813 83768 11846 13830 69189 16480 17025 13505 18703 268379 107767 15516 100040018 13244 22330 93726 54159 15129 16993 56318 55950 70536 17395 21930 100040603 56444 20195 212114 53856 18600 11593 74039 73690 13367 56016 18475 545878 20868 30960 16783 80796 54672 108888 17064 11605 56031 66222 96979 69550 13861 12283 20972 71517 69537 15369 381812 14667 66508 16678 545987 19264 80860 67862 66612 20409 74012 14325 19288 76299 66060 268373 14824 83409 100039636 108015 14319 22177 73834 26458 113868 11975 20614 27060 668218 16819 24088 71902 23845 12333 105855 68682 15006 20619 13058 13057 56485 19164 59287 17002 12182 58222 67963 26364 69146 50701 12267 53378 11772 434174 13205 67771 12798 66713 19342 17319 19336 70349 14191 15926 110006 109754 13035 15212 11676 14387 12091 11881 14131 66824 14595 18793 75612 14302 227753 110078 110095 12491 109154 18436 19340 15442 50917 74096 12505 66934 212032 56455 77559 71665 66681 231507 11758 70568 19325 68365 235661 266692 217303 67474 18641 13424 13629 19152 76507 18648 11487 17159 15439 13510 110173 18772 109620 11891 18746 27357 20932 11689 12266 16409 67781 16423 72157 16411 16414 232714 71884 50770 105722 232449 11674 11980 12475 225471 76295 19353 104112 18950 15170 71955 11717 235606 223646 11821 67075 67512 57437 108995 210992 216134 13200 66848 269523 20719 11886 18792 13001 14751 76501 16784 12238 22154 17394 16854 13036 226977 14293 20201 20202 12765 227288 240047 11501 74125 19156 16004 19345 19344 319642 19261 108078 19346 20343 57349 12469 12461 11848 227613 13010 19349 18805 22139 52588 668101 22072 544963 330122 232790 16498 17380 16790 94176 70495 52331 80910 52855 83382 20430 329547 56212 13350 13033 16592 57264 21858 12306 16410 18636 11783 69562 20740 56615 12331 193740 269116 72269 15519 16211 100037258 19025 19204 68197 14289 19339 13002 20813 18010 216197 22361 22320 100561 15481 105245 64138 21762 22123 19181 19182 54473 18033 19166 26442 69077 66997 23997 17463 227394 19177 19170 18173 66413 28240 216445 59029 70247 70719 11883 16408 69116 14127 18753 21938 13040 12010 13030 20716 12359 117586 11767 23912 14134 11537 12273 18613 76763 12512 72512 68891 22596 104009 14375 76577 20703 11625 20527 52120 14569 381809 106572 17474 13032 245828 333883 18407 19330 224794 67706 DEFECTIVE RFT1 CAUSES CDG-1N%REACTOME DATABASE ID RELEASE 96%4570571 Defective RFT1 causes CDG-1n 328370 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.5 Intraflagellar transport 81896 16570 56455 110350 12589 21821 16559 76411 76779 16579 73668 245866 67661 238799 75465 72421 109181 68259 67344 67068 76568 66061 16568 72938 213081 213575 16569 217935 74019 68097 264134 74682 71820 67694 100041639 67042 67286 73916 78802 106633 APAP ADME%REACTOME%R-HSA-9753281.3 APAP ADME 76408 14871 26357 231396 13106 394434 94284 14863 17250 20859 17960 71522 20860 207182 20887 12780 109652 14598 17961 23887 27416 239273 66054 394436 CHOLESTEROL BIOSYNTHESIS FROM ZYMOSTEROL (MODIFIED KANDUTSCH-RUSSELL PATHWAY)%REACTOME DATABASE ID RELEASE 96%9969901 Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) 13595 13360 74754 235293 MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.3 Mitochondrial translation initiation 64658 66419 64660 78523 94061 623346 102060 50529 100040519 68565 99045 66973 69163 52443 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 67681 64655 107733 68537 18100 67707 94066 60441 218506 66230 68463 65111 74600 107734 66242 28028 68735 622268 27398 94067 67840 68836 79044 94065 57312 75398 68572 69606 67308 64659 56282 76784 66292 24030 76366 66121 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME%R-HSA-9033500.4 TYSND1 cleaves peroxisomal proteins 16922 15488 71767 113868 20280 11430 228061 LACTOSE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%5653890 Lactose synthesis 16770 20525 14595 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME DATABASE ID RELEASE 96%210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 328572 12914 246086 21410 14534 11925 18519 18128 333639 15379 15205 270118 19664 103806 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 96%111931 PKA-mediated phosphorylation of CREB 18747 640703 224129 19088 11512 11513 11514 19108 19087 19084 11515 18749 104110 432530 210044 104111 19085 BRIGATINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717319 brigatinib-resistant ALK mutants 11682 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.5 Golgi Associated Vesicle Biogenesis 20404 320634 12874 117197 245638 27059 18457 224139 94245 80912 11777 170760 20615 21987 232946 20661 77929 67804 69178 109689 11768 11769 11774 108012 11764 11765 11767 252903 233489 18704 22320 14533 11840 66616 15481 67489 20955 231580 14325 67602 108011 29816 105245 13430 216705 72685 108124 16004 14319 19345 22318 22042 INTESTINAL ABSORPTION%REACTOME DATABASE ID RELEASE 96%8963676 Intestinal absorption 20537 20526 56485 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%352230 Amino acid transport across the plasma membrane 103098 53896 56774 14411 30962 20532 215113 67760 50934 209837 21366 20514 215335 11989 234967 55963 69354 74338 76257 102680 20540 330836 72401 246049 17254 11987 214663 105727 20539 26570 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.4 Defective factor IX causes hemophilia B 14069 56316 14058 14071 14723 14724 54368 14729 109821 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME%R-HSA-606279.3 Deposition of new CENPA-containing nucleosomes at the centromere 319178 319183 72155 319182 232440 319190 217653 20892 233532 100038822 70645 319176 66311 66578 319181 12617 83815 12615 18148 66570 56505 19646 70454 67733 71876 76464 245688 320394 102920 319169 60411 66336 93762 78303 15267 319188 15270 319168 69928 319167 26886 52504 624153 319186 382522 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME%R-HSA-5632927.2 Defective Mismatch Repair Associated With MSH3 17685 17686 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%9661070 Defective translocation of RB1 mutants to the nucleus 19645 RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME DATABASE ID RELEASE 96%6791461 RPIA deficiency: failed conversion of RU5P to R5P 19895 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 96%975163 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation 68652 17087 12475 225471 106759 108960 667035 21898 22190 66513 26409 22034 66724 RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 96%5213460 RIPK1-mediated regulated necrosis 14103 56532 14252 74568 12539 22030 108155 56424 21933 67245 11796 11798 53378 667035 71609 22190 14082 15519 14102 14251 18571 22195 22035 50873 16396 12370 19766 11797 PRE-MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72163 pre-mRNA splicing 66053 66983 15381 19655 70616 68598 67959 20462 107701 67480 72047 68092 74326 67500 433702 75956 56031 80744 66101 70225 68879 320632 67418 212880 66585 22380 74351 54723 83486 19134 545085 66877 244672 238831 23983 24010 18521 20227 83701 74255 57905 67229 68479 70312 330361 66177 67050 209416 76522 72654 20222 28035 72886 18949 60321 66492 71715 215051 66618 230596 70052 70767 67922 66070 66381 77644 66810 108160 319322 100034361 66801 237859 19205 68592 27967 68035 217207 76936 67471 69757 68988 208768 71702 76793 22668 68981 67684 20639 209003 229279 227707 101943 81898 67439 94315 20646 192159 53317 15382 53379 56258 59013 98758 11991 11834 15388 15387 66055 68816 50783 67678 54633 66094 67465 69192 78651 27756 67285 66373 236732 67958 68183 76479 20624 66642 75062 27366 228005 28000 13204 100041953 76938 13207 233908 66125 64340 622469 225027 15481 67996 22608 51796 192160 71713 53817 233073 20382 110809 60365 20383 21681 68134 108014 192170 69207 19826 193116 66441 17149 100040029 107686 384091 666609 100040177 67010 68705 20641 98053 20638 66420 69833 67710 245841 69920 67332 20022 20020 231329 20021 72198 69241 17749 100043714 170791 20630 14105 20637 53607 56070 67039 72459 56194 100336 72935 13211 56215 51810 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 96%163125 Post-translational modification: synthesis of GPI-anchored proteins 76942 30060 228812 64931 170745 74762 18793 68311 230801 68404 330908 80883 26434 212518 72434 268890 14276 72585 23934 76768 53614 21684 13480 246190 69363 13481 72084 433931 329777 320772 668145 109979 72373 27392 76486 109978 269295 234700 14731 56703 57256 70325 232973 235505 12182 56746 68563 68453 68468 78928 66459 276846 244682 18700 67292 11647 110417 26464 71897 22361 11650 18701 18488 67556 17068 21683 71003 67133 14756 239827 327942 55981 237847 21838 235106 70163 241062 17069 320840 70574 114654 56047 SHOC2 M1731 MUTANT ABOLISHES MRAS COMPLEX FUNCTION%REACTOME DATABASE ID RELEASE 96%9726840 SHOC2 M1731 mutant abolishes MRAS complex function 110157 17532 109880 19047 19046 11836 56392 54401 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.2 NOTCH3 Activation and Transmission of Signal to the Nucleus 22608 18011 13388 16449 240055 225164 11487 54485 13649 16450 18131 66894 21335 19164 19165 100042305 208117 59287 100039623 667035 76580 22190 13645 PEROXISOMAL LIPID METABOLISM%REACTOME%R-HSA-390918.7 Peroxisomal lipid metabolism 56185 80911 111175 93732 74159 74147 171282 16922 11666 26458 12908 56794 15488 17117 113868 67131 67528 170789 26378 74114 110959 20524 74121 PREDNISONE ADME%REACTOME DATABASE ID RELEASE 96%9757110 Prednisone ADME 100559 15484 15483 18671 12401 22236 11657 77337 13114 DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME DATABASE ID RELEASE 96%3560796 Defective PAPSS2 causes SEMD-PA 23972 RHOV GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013424 RHOV GTPase cycle 13836 214230 17973 269401 101565 216963 56513 20742 22284 83669 73178 59009 59069 26431 244895 71228 70584 74201 58220 54126 229658 29875 75415 17974 218581 67300 228543 270163 26403 224105 18708 53382 18479 20740 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.9 Transcriptional regulation by small RNAs 319178 233833 319183 319182 232440 236511 319190 319149 319176 319181 15077 66420 69833 320727 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 319169 625328 15267 78303 319188 319168 15270 319167 19384 624153 239528 319186 382522 CRIZOTINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717326 crizotinib-resistant ALK mutants 11682 NEPHRIN FAMILY INTERACTIONS%REACTOME%R-HSA-373753.5 Nephrin family interactions 74769 109711 17973 11474 20742 11472 29875 12488 50791 73178 54631 170643 17974 12361 60595 67703 243911 18708 18709 14360 18706 20740 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.7 Choline catabolism 100434 30805 110695 68682 218865 12116 74129 192166 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME DATABASE ID RELEASE 96%5362798 Release of Hh-Np from the secreting cell 103978 16147 11491 77583 214240 20423 13363 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 96%72689 Formation of a pool of free 40S subunits 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 27979 56347 19989 13669 76808 53356 19899 68135 100043184 55944 19921 66085 19934 73830 100043755 16341 223691 667035 54709 319195 100042807 100043209 98221 68193 66235 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-5649702.4 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 18970 382913 18294 22594 72774 16882 59047 ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.5 Acyl chain remodeling of DAG and TAG 67800 116939 13350 23945 245532 66853 668257 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9024909 BDNF activates NTRK2 (TRKB) signaling 18212 12064 FMO OXIDISES NUCLEOPHILES%REACTOME DATABASE ID RELEASE 96%217271 FMO oxidises nucleophiles 14261 55990 14262 IRAK1 RECRUITS IKK COMPLEX%REACTOME DATABASE ID RELEASE 96%937039 IRAK1 recruits IKK complex 16151 16179 93834 93765 67245 66589 240518 22034 12675 16150 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.5 Downregulation of ERBB4 signaling 107568 667035 22190 16396 17999 20779 SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME DATABASE ID RELEASE 96%9703648 Signaling by FLT3 ITD and TKD mutants 14389 12575 18176 20662 20851 20850 15461 18712 50490 14784 12048 18708 14255 19247 18706 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME%R-HSA-110329.4 Cleavage of the damaged pyrimidine 319178 319183 319182 232440 319190 57321 319176 319181 17193 234258 71726 319152 382913 18294 21749 72774 497652 18207 21750 319169 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 SPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%428157 Sphingolipid metabolism 11881 14466 244757 108105 17250 50935 58911 271970 11886 67902 225742 71949 26938 75292 545260 101540 67630 230379 239559 11883 53897 103236 76893 66190 19025 432628 74442 66183 14344 171168 14343 50877 74008 338521 77041 20773 67689 77626 26879 22234 14421 545975 14420 241447 104725 66844 56632 20698 19012 50784 56491 22239 20454 18760 238011 230101 433323 70059 208449 13244 54447 67260 67916 227102 268656 228677 18010 93898 242083 23956 223753 81535 70750 20397 76303 56336 56386 30960 20597 11605 17113 14667 66612 26357 66427 19156 20598 58994 54218 20444 70893 15212 15211 12091 MPS II - HUNTER SYNDROME (HS-GAG DEGRADATION)%REACTOME%R-HSA-2206296.5 MPS II - Hunter syndrome (HS-GAG degradation) 15931 DEFECTIVE GALNT3 CAUSES HFTC%REACTOME%R-HSA-5083625.4 Defective GALNT3 causes HFTC 100039649 140474 224116 14425 269328 353328 17063 73732 17829 METABOLISM OF STEROIDS%REACTOME%R-HSA-8957322.4 Metabolism of steroids 17117 12640 13075 244209 16211 12012 20186 13123 104086 93732 57357 13122 77337 208665 101502 83702 19384 19014 229003 76408 13116 13115 14104 98386 110115 56050 21372 109151 17977 17978 59035 81004 66993 27413 13070 28250 64291 12914 56406 28253 26458 15488 170789 73166 231070 270669 110196 14137 100040592 20683 66397 18044 18045 18046 235293 68603 69608 218811 14732 13124 99683 100042622 20775 76205 20249 59045 235623 12257 192156 170459 15484 170439 20845 15483 72999 12401 13121 20788 13360 107476 100705 14593 16987 17764 56453 77371 20181 319554 22337 17855 19013 20334 59004 22196 68165 100043429 14149 14148 20787 19141 74411 74754 66234 14473 18194 110460 68865 13595 15490 100017 13081 94224 76303 13072 13074 71720 20494 15492 78925 228983 20493 15497 12642 106407 16866 65969 13079 15486 15487 330962 66065 26459 114664 170460 14187 99031 71240 105349 100273 11657 16204 56348 14725 15485 18976 11677 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%446652 Interleukin-1 family signaling 71481 211550 19249 19250 19253 104831 26410 19259 19256 16182 24058 331461 16068 320139 56294 19255 73914 26395 17127 16189 16163 16174 26399 69677 26398 18412 107527 26406 77125 54450 26419 215274 21762 22123 12675 17082 19179 19181 19182 54473 23996 19184 215257 18033 26440 19166 18035 19167 18036 26441 54448 11820 26442 69077 66997 23997 12234 56436 17463 57296 20422 56480 26445 26446 19172 19173 19175 19697 19177 21402 56438 16150 26443 26444 16151 19170 192656 17874 66413 16179 26965 667035 22190 59029 20203 26409 20210 67089 24110 103583 11689 257632 70247 266632 80750 223664 107607 69721 231130 93834 270151 11596 22059 16181 67454 240518 71966 108960 59025 16178 16176 12362 12370 16173 22030 19258 67245 69146 18034 16177 16175 434174 19248 66513 93765 66589 19247 22034 66724 68652 15170 20848 13035 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 96%9634635 Estrogen-stimulated signaling through PRKCZ 15461 18762 26413 18176 18607 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-HSA-191650.4 Regulation of gap junction activity 14609 21872 FORMATION OF THE URETERIC BUD%REACTOME DATABASE ID RELEASE 96%9830674 Formation of the ureteric bud 22411 17300 14573 20472 20563 19713 14234 12159 16412 15431 268902 241226 18504 15396 114249 109663 14585 23892 20471 14048 58198 REGULATION OF FXIIA AND PLASMA KALLIKREIN ACTIVITY%REACTOME%R-HSA-9855719.1 Regulation of FXIIa and plasma kallikrein activity 385643 58992 232345 16621 12258 94175 12261 16678 18793 REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME%R-HSA-6804759.4 Regulation of TP53 Activity through Association with Co-factors 29813 53325 228829 209456 333654 22059 11651 11652 22061 18996 22062 18997 21981 23797 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 96%157858 Gap junction trafficking and regulation 14618 13132 21872 14621 225152 14615 353155 14610 14613 14617 14612 14611 74325 14622 14620 14616 14623 118454 11773 13430 14609 14619 67300 17920 13429 12757 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.3 NRAGE signals death through JNK 102098 20663 22324 277360 18049 22325 622434 545156 16443 12015 57257 20662 17207 16800 13605 109904 230972 213498 207212 71704 234094 223435 56349 16801 94275 19418 75547 19353 18053 72754 69632 213649 24001 224014 56321 230098 53972 30938 77669 442801 226970 54126 101497 269608 328967 14163 26382 268739 26419 14674 73341 21844 12125 236915 109934 DEFECTIVE MMACHC CAUSES MAHCC%REACTOME DATABASE ID RELEASE 96%3359474 Defective MMACHC causes MAHCC 67096 GAP JUNCTION TRAFFICKING%REACTOME%R-HSA-190828.3 Gap junction trafficking 14618 13132 14621 225152 14615 353155 14610 14613 14617 14612 14611 74325 14622 14620 14616 14623 118454 11773 13430 14609 14619 67300 17920 13429 12757 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975956.2 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 622534 238217 14852 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 68092 433702 19704 27207 67097 670832 633683 20044 27050 208643 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 14853 672214 66481 225058 100038875 100038991 68028 225363 100043000 67891 100043295 18458 ACTIVATION OF INFLAMMATORY CASPASES%REACTOME DATABASE ID RELEASE 96%9686114 Activation of inflammatory caspases 12367 16176 16173 640703 66222 12363 69146 SIGNALING BY FGFR%REACTOME DATABASE ID RELEASE 96%190236 Signaling by FGFR 14172 80857 14170 19205 14180 14178 12402 14177 76936 67112 64654 14175 14174 14173 14164 83379 71436 109880 68705 98053 667035 22190 66420 69833 67710 245841 69920 26413 20022 26417 327826 20020 231329 20021 69241 17749 100043714 15382 399558 116701 396184 18176 59013 20662 98758 15461 19052 19053 51792 18708 18706 68092 24064 17346 433702 19247 14425 114715 114716 14388 21814 14181 67903 107971 72514 18803 93686 77411 80903 21843 21841 14186 14165 DEFECTIVE CLEAVAGE OF FV VARIANT AT R334%REACTOME%R-HSA-9930479.1 Defective cleavage of FV variant at R334 14067 19128 19123 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 96%182218 Nef Mediated CD8 Down-regulation 11771 11772 71770 232910 11773 12526 108664 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN INVASION%REACTOME%R-HSA-9854909.3 Regulation of MITF-M dependent genes involved in invasion 66355 13367 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 96%204174 Regulation of pyruvate dehydrogenase (PDH) complex 14874 381511 68263 228026 18604 236900 27273 75387 27402 18597 18598 382051 319518 13382 235339 CAM PATHWAY%REACTOME%R-HSA-111997.3 CaM pathway 12326 19088 55984 19108 19087 19084 104110 12322 12323 108058 12325 432530 210044 104111 18747 100039592 640703 224129 18753 11512 11513 110355 11514 18575 11515 18574 18573 18749 207565 18752 18750 19085 SIGNALING BY RAS GAP MUTANTS%REACTOME%R-HSA-9753510.2 Signaling by RAS GAP mutants 15461 16653 18176 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 96%381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 18508 66624 12387 14695 14526 21416 233081 66286 56529 18548 64337 16846 12591 225642 236781 76687 13482 107221 69019 242851 14688 SIGNALING BY KIT IN DISEASE%REACTOME%R-HSA-9669938.5 Signaling by KIT in disease 17096 22612 18176 20846 20662 20851 20848 20850 15461 18710 16590 16818 18708 18709 16452 14360 18706 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 96%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 12387 12550 56324 20779 56374 15239 381293 20867 12389 83669 20844 76804 18844 108670 12874 59009 232339 107746 14786 223881 208994 26416 108686 66922 227937 20257 67586 71228 26413 68187 26417 93840 11671 327826 22325 77480 19094 54401 57257 246710 50875 29875 20662 19877 15381 83946 106504 52666 109331 16800 11465 263803 12848 52428 19230 13605 17920 270163 22352 20166 19878 236920 76626 26403 13830 56381 16480 19655 68743 53382 20874 15516 213498 70804 100043806 12704 269061 243362 26891 110596 56320 207212 109711 19285 12539 71704 20462 234094 69288 11464 242202 50768 56349 54216 16801 11852 404710 13367 75547 103573 20868 268301 17978 320795 109333 72754 208846 69632 213649 24001 224014 230098 53972 15369 30938 66508 442801 226970 235611 54126 101497 269608 640703 14163 26382 268739 14674 73341 11853 16906 54411 105827 22627 195727 210293 50884 71709 22042 83767 170758 329165 109934 106952 12532 71893 26934 110279 330177 75409 105855 242687 216963 386750 17969 20947 212285 237038 70497 320634 27061 77579 11308 71960 20619 224480 11856 16885 13058 16886 241275 13171 13057 108100 76117 218952 26431 17970 101314 17972 66898 71302 71544 13385 12261 14251 12385 14252 67784 76709 73178 12229 56443 78514 17827 80987 68089 68653 67771 11867 59040 26554 56378 226525 66713 74117 13542 245880 13544 13543 22376 215280 68524 67414 70827 214952 229877 170731 67299 223701 330319 76884 66894 223870 12447 19249 12576 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 217866 19052 105782 73804 14269 19053 22379 51792 80837 20877 214459 381318 14467 66871 52696 226751 26886 76088 66934 218756 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 19418 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 21844 67052 232987 208869 12236 236930 107971 110379 69928 13427 76499 329251 13426 68458 52504 17931 13424 228421 236915 22342 16449 21873 13511 13510 109620 19299 58220 227377 15267 319168 319167 224105 319186 319178 319183 319182 259302 223666 14270 67095 319190 117600 319176 319181 19353 20514 319169 625328 78303 319188 15270 16818 18750 624153 382522 18806 232440 319149 22628 22324 15077 269523 18710 17886 72565 74201 12988 67268 13206 55948 12638 18708 18709 18479 18706 18607 98386 101565 18481 16594 232943 16593 19354 20201 20202 74764 73296 14609 12466 319642 12468 22143 12461 18762 11848 56382 102098 56513 68146 22319 11855 277360 192662 263406 11857 14570 68813 11461 19349 18805 624814 70584 68428 56418 56384 70361 233103 229658 544963 622434 100039786 16572 66251 16573 68202 16412 545156 16443 13726 23943 75739 140579 628438 71782 17207 94176 330662 94190 16709 52331 218581 84004 21917 56491 109904 238130 230972 20430 192176 223921 56419 380664 104445 56389 13836 59079 108037 23988 67938 69922 17904 223435 107589 330914 232906 56212 71435 228359 17283 17880 59069 19046 66905 320271 99982 12345 14083 18016 76378 11352 53332 100039683 233406 17974 67300 17063 17925 14026 20740 214230 17973 20742 20663 241656 18643 18645 15519 11350 21927 74194 64652 216197 12709 20355 233877 22284 19229 51796 53817 69581 238505 75669 22637 213522 329366 56784 20401 233071 75974 12549 58996 66146 225326 214345 208263 192652 239027 70350 74159 71409 74018 106326 244867 70598 192192 319899 260409 57778 386649 226823 21763 18751 216445 69710 211499 244895 216831 268970 70719 328232 244418 101240 232201 73167 78816 228482 72729 104252 11835 231532 18753 68917 27360 69668 14218 71972 225358 214137 75415 171207 74734 71703 77038 228543 58804 56699 214804 269682 77006 223254 102075 66087 11736 23912 207425 19765 54004 20807 73910 83397 269401 434204 207495 76763 94221 11858 213783 13043 100038946 71085 545481 23853 210998 233489 219140 226652 14787 11854 232237 27984 75089 76577 230654 20403 12631 22631 22629 76983 106628 18817 22346 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9632700 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 12571 12567 12578 ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.9 Estrogen biosynthesis 15486 66065 15485 114664 14187 13075 CHD CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9937848 CHD chromatin remodelers 232440 12387 319149 240442 13445 11538 269610 106795 22780 22779 78266 228880 52004 15077 17191 233410 11819 22778 140858 622675 70998 14121 19646 234366 16002 56811 245688 23942 17192 70802 101631 73503 12006 67772 328572 67959 109151 107701 72047 17135 20833 18104 18024 114741 22026 76246 71389 214498 12914 66317 212880 21413 235497 22083 17927 17928 54624 68479 20222 216848 14377 319322 27967 107686 384091 666609 12412 107932 68981 21423 20639 20641 101943 20638 81898 20646 67332 21406 22196 15267 319168 319167 66055 229542 319186 319178 319183 319182 67465 319190 319176 13018 72293 67958 319181 241128 320790 76479 75062 12648 244059 116871 13204 116870 76938 66125 319169 12417 625328 78303 319188 15270 433759 15182 624153 18534 382522 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 96%380284 Loss of proteins required for interphase microtubule organization from the centrosome 20873 68121 12534 78887 22628 225745 231123 227613 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 83922 75296 26370 76707 219072 13589 225659 18472 76478 78177 28135 214444 76816 54130 18817 381644 13427 22627 13424 27373 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME%R-HSA-399997.5 Acetylcholine regulates insulin secretion 18796 18797 14672 14682 18795 12671 14676 14675 17118 18750 NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013700.2 NOTCH4 Activation and Transmission of Signal to the Nucleus 100042305 16449 208117 59287 100039623 11487 54485 22631 18132 19164 19165 DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 96%3595174 Defective CHST14 causes EDS, musculocontractural type 12111 29873 121021 13003 13004 12032 13179 72136 RHOBTB2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013418 RHOBTB2 GTPase cycle 51796 56320 12461 26554 109711 12539 20462 53817 246710 50875 15381 83946 106504 11465 12466 19230 17920 76626 19655 53382 15516 12468 15519 REGULATION OF CDH1 FUNCTION%REACTOME DATABASE ID RELEASE 96%9764561 Regulation of CDH1 Function 56436 17463 57296 20422 12388 26445 12387 26446 19172 12550 19173 19175 19177 20779 26443 26444 19170 13858 104836 14694 66413 667035 22190 59029 67089 70247 13040 16480 13030 22330 12385 53325 17246 13430 21762 22123 19179 19181 19182 23996 19184 105837 26440 19166 19167 26441 26442 69077 66997 23997 VPU MEDIATED DEGRADATION OF CD4%REACTOME%R-HSA-180534.3 Vpu mediated degradation of CD4 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 26443 26444 19170 66413 667035 22190 59029 67089 70247 21762 22123 12504 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DISEASES OF CELLULAR SENESCENCE%REACTOME%R-HSA-9630747.5 Diseases of Cellular Senescence 12571 12567 12578 NUCLEOTIDE SALVAGE%REACTOME DATABASE ID RELEASE 96%8956321 Nucleotide salvage 75894 18950 229665 15452 22271 109674 11717 57813 105446 11534 11486 11821 66355 13178 27369 21877 67365 80914 22245 68556 76654 72962 72269 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer 21803 21812 21813 17126 17127 GLYCOSPHINGOLIPID TRANSPORT%REACTOME%R-HSA-9845576.2 Glycosphingolipid transport 79554 56356 231999 272636 23943 12752 11840 52635 DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME%R-HSA-5619085.4 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) 13487 ESSENTIAL PENTOSURIA%REACTOME DATABASE ID RELEASE 96%5662853 Essential pentosuria 67880 INOSITOL PHOSPHATE METABOLISM%REACTOME DATABASE ID RELEASE 96%1483249 Inositol phosphate metabolism 18796 18797 56409 18795 75678 102954 27399 271424 227399 71207 327655 320634 19211 269437 104015 16330 16331 16332 269615 18798 18799 72469 18802 217837 228550 74055 320404 19386 114875 104759 233011 170762 108989 231042 227699 223921 227720 445007 269113 66679 18141 107939 69482 71805 54563 76500 234779 19069 70699 72787 18226 218210 54384 210376 69718 17330 69912 103468 640703 234865 56727 114663 55980 71780 212111 59015 16329 69736 110379 18803 269180 234515 SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.9 SLC transporter disorders 19743 11998 117591 54140 26361 12000 63993 236794 15275 331004 114479 214111 20495 20497 107723 19386 231103 20537 20526 13162 228368 18400 24060 170762 108989 231042 227699 223921 227720 445007 269113 66679 18141 107939 69482 71805 229782 54563 56774 19069 13521 70699 30962 20532 72787 18226 218210 235504 18174 20520 53945 11416 74338 20521 20510 69912 54403 102680 20538 20512 238384 20540 103988 26569 246787 103468 246049 22232 17254 23985 72027 13487 216227 20525 20501 104245 234865 12215 20516 15203 28253 59015 170441 69736 71279 317750 12870 24059 110379 20533 20505 142681 20531 TICAM1 DEFICIENCY - HSE%REACTOME%R-HSA-5602566.3 TICAM1 deficiency - HSE 106759 142980 HSF1-DEPENDENT TRANSACTIVATION%REACTOME DATABASE ID RELEASE 96%3371571 HSF1-dependent transactivation 328572 12914 81489 74370 56717 100043508 67605 68196 12322 80888 12323 108058 193740 12325 56716 14228 15516 12955 15512 15481 15499 15482 15519 P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME%R-HSA-193670.2 p75NTR negatively regulates cell cycle via SC1 18053 433759 18049 15182 15183 72843 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 96%189445 Porphyrin metabolism 394433 19044 70383 15368 14080 26357 17250 28253 12780 15288 22276 12892 17025 15369 11657 11655 11656 109778 14151 233016 226139 394436 22275 INTEGRATION OF ENERGY METABOLISM%REACTOME%R-HSA-163685.7 Integration of energy metabolism 18796 18797 18795 55979 19087 19084 238276 16514 58805 68465 11450 72674 20910 229709 16438 16439 18747 109905 12491 16440 73699 29875 19052 19053 51792 108099 12288 12286 12290 21770 14104 56808 12296 12297 20869 20525 233081 21351 22318 11551 20614 11553 20907 18639 240444 16334 21881 238076 14675 14697 12671 14710 14699 107476 66066 100705 14700 20927 14708 14706 14672 14704 14695 14652 14676 16500 14693 20526 268345 64337 14709 14682 14701 56508 223864 14702 14696 14527 14526 19088 50790 104110 74205 14678 14677 104112 432530 17118 210044 104111 21428 53420 14688 12289 224129 11512 11513 11514 108079 11515 18749 108097 18750 19085 EXPRESSION AND TRANSLOCATION OF OLFACTORY RECEPTORS%REACTOME%R-HSA-9752946.3 Expression and translocation of olfactory receptors 258299 258381 258992 258486 258650 258487 257884 18367 258991 258736 258097 258794 52250 258857 259111 258836 258821 56858 258542 258405 258935 258420 258321 259036 259034 259119 18324 258697 258432 258675 258673 258677 257905 258334 258025 667918 258832 258469 258882 258601 258853 259112 258657 18366 18328 258470 258600 258338 258455 259053 258027 56015 259041 258573 259049 258563 259013 117004 258846 258105 329460 258854 258930 258281 257962 258387 18314 259063 258896 404315 258453 257883 258586 258869 258587 668825 258363 80706 258362 257909 258575 258358 258658 258616 258941 258944 258618 18369 258216 258866 258580 258582 16825 228228 258160 258267 258350 258544 258772 258640 258608 259015 404329 259110 546747 258636 259109 258715 259014 16870 258395 259051 258680 259045 258155 259100 258154 258805 258147 257916 258572 258990 18313 258749 258340 18331 259097 258036 258355 404318 259047 258980 259004 258407 259017 259019 170639 258371 259113 258656 258562 436002 258424 258752 18365 258939 258961 258268 258305 100038859 100043474 259074 258507 258427 259122 257917 404346 258819 258672 259075 259040 259058 258746 57251 258614 258700 258694 258478 258443 258178 258222 258775 258352 258248 258831 258196 258458 18315 258776 259054 404317 258720 258985 258690 258373 404222 18317 258717 258937 668035 259071 258292 258531 258756 258238 258710 259106 258322 258946 258975 258763 258325 258536 258925 258924 258706 404331 258302 258804 258713 239766 258270 258704 259147 18343 18310 258310 258303 259115 259012 258357 258347 259035 258296 258179 259066 258206 259095 259092 244187 258098 259089 258163 224055 258914 258319 258759 258609 257898 258287 258506 258922 258316 258354 18346 259002 258814 259067 258620 258207 18341 18357 18330 218066 258016 257972 29849 258729 545140 258769 257985 258075 258515 258439 258271 258408 13591 258153 18312 258481 258318 258275 404319 258151 258933 258039 18322 258908 258702 258703 258659 MPS IIIC - SANFILIPPO SYNDROME C%REACTOME%R-HSA-2206291.5 MPS IIIC - Sanfilippo syndrome C 52120 NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME%R-HSA-5654732.3 Negative regulation of FGFR3 signaling 327826 14172 80857 14180 12402 24064 64654 17346 14175 14173 14164 19052 109880 19053 51792 667035 22190 80903 19247 26413 26417 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME%R-HSA-110357.3 Displacement of DNA glycosylase by APEX1 17193 71726 11792 18294 18207 268395 DISEASES OF DNA REPAIR%REACTOME DATABASE ID RELEASE 96%9675135 Diseases of DNA repair 12021 17685 17686 17350 81601 17688 327762 20422 19361 114714 22427 19718 69263 15574 11920 12189 12190 234258 235610 231724 237911 18294 19355 72774 57434 18207 225182 26909 235559 12144 68275 106344 72151 68240 233826 19891 19367 19356 19362 19360 17535 21975 19363 19364 27354 18861 ORGANIC ANION TRANSPORT BY SLC22 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%561048 Organic anion transport by SLC22 transporters 18399 19879 20521 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME DATABASE ID RELEASE 96%5619058 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) 28253 INTERFERON ALPHA BETA SIGNALING%REACTOME DATABASE ID RELEASE 96%909733 Interferon alpha beta signaling 16451 54131 100038882 15006 16364 240095 667803 667035 22190 24110 14991 16211 19106 80876 23960 246727 56045 56417 231655 19246 15007 66141 16362 58185 70110 54139 57444 52668 16363 667370 112419 15958 16646 76500 24014 12702 13653 54721 16913 54123 16391 20847 69550 24015 19247 15975 246728 15900 15170 15977 20846 27056 12703 14469 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.3 Defective Base Excision Repair Associated with NEIL1 72774 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME%R-HSA-5624138.4 Trafficking of myristoylated proteins to the cilium 19889 106840 56350 74025 12879 UPTAKE OF DIETARY COBALAMINS INTO ENTEROCYTES%REACTOME%R-HSA-9758881.4 Uptake of dietary cobalamins into enterocytes 22072 66473 93835 14603 19300 68421 65969 TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%6784531 tRNA processing in the nucleus 67053 70047 208366 227522 54364 19386 19384 170762 108989 231042 227699 223921 227720 445007 269113 66679 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 67676 102614 69912 76265 68215 66637 103468 74097 68045 73192 68626 104721 117109 98985 66161 234865 381802 66078 108062 28088 67724 67106 59015 98404 69736 94230 54188 110379 IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975144.3 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation 16151 16179 93834 93765 67245 66589 240518 22034 12675 16150 DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.5 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) 72027 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME DATABASE ID RELEASE 96%5654228 Phospholipase C-mediated cascade; FGFR4 14172 80857 14170 14180 14177 64654 14175 14173 14164 83379 18803 80903 14186 DEFECTIVE AMINO ACID TRANSPORT BY SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.5 Defective amino acid transport by SLC7A7 causes lysinuric protein intolerance (LPI) 20540 17254 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 96%450302 activated TAK1 mediates p38 MAPK activation 68652 19094 107607 102626 26399 108960 16151 17164 192656 26397 16179 26416 66513 93765 66589 26409 22034 257632 66724 TCR SIGNALING%REACTOME DATABASE ID RELEASE 96%202403 TCR signaling 16428 12234 77647 56436 17463 57296 17973 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 192656 12042 66413 22323 26965 667035 19211 22190 19271 240354 59029 26409 16331 67089 103583 70247 12988 12500 12501 12502 12504 17444 224105 18708 18709 18479 18706 18607 74769 18481 234779 94212 100041766 216150 93765 66589 18761 22034 14969 19264 14968 68652 21762 22123 12675 108723 19179 19260 19181 19182 22376 23996 19184 18033 26440 18803 19166 216080 18035 16818 19167 26441 16822 22637 26442 16797 69077 14026 630146 66997 23880 23997 DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371599 Defective HLCS causes multiple carboxylase deficiency 18563 78038 110821 66904 72039 107476 110948 APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 96%176409 APC C:Cdc20 mediated degradation of mitotic proteins 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 30939 18005 12428 12237 107995 12427 56150 21762 22123 19179 19181 19182 217232 23996 56317 12236 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 GLYCOSPHINGOLIPID METABOLISM%REACTOME%R-HSA-1660662.8 Glycosphingolipid metabolism 11881 14466 244757 108105 50935 58911 271970 11886 67902 225742 26938 545260 239559 11883 53897 19025 14344 14343 50877 74008 77041 77626 26879 22234 14421 14420 22239 20454 238011 230101 54447 18010 23956 223753 56336 56386 20597 11605 17113 14667 19156 20598 58994 54218 20444 70893 15212 15211 12091 SLC25A15 VARIANTS CAUSE HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINEMIA SYNDROME%REACTOME DATABASE ID RELEASE 96%9956508 SLC25A15 variants cause hyperornithinemia-hyperammonemia-homocitrullinemia syndrome 18408 DIFFERENTIATION OF T CELLS%REACTOME DATABASE ID RELEASE 96%9945266 Differentiation of T cells 216848 22632 232232 20602 18129 20586 20230 18128 79221 107932 16364 270118 170787 66310 140858 19646 234366 22022 213464 214162 56233 245688 208727 23808 12418 23942 16189 17192 16163 21926 17132 14281 103806 229542 12151 15978 328572 19763 21372 54383 13619 17283 333639 12399 241915 14462 16190 12416 20851 20850 81004 20852 15185 19821 70315 15184 15183 116871 20185 18986 116870 12914 23871 494448 14534 20849 18018 18019 18519 30951 16162 57765 53314 19664 16476 433759 16191 50794 18987 15182 PYRIMIDINE SALVAGE%REACTOME%R-HSA-73614.5 Pyrimidine salvage 21877 67365 22271 80914 57813 22245 68556 76654 13178 72962 72269 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME%R-HSA-167290.4 Pausing and recovery of HIV elongation 20922 20833 68705 98053 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 20020 231329 12454 20021 69241 17749 100043714 58202 67923 27224 27632 20924 24116 12455 72949 13716 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 96%114294 Activation, translocation and oligomerization of BAX 12028 12122 DEFECTIVE BINDING OF VWF VARIANT TO GPIB:IX:V%REACTOME DATABASE ID RELEASE 96%9846298 Defective binding of VWF variant to GPIb:IX:V 14723 14724 54368 14729 22371 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.4 EGFR Transactivation by Gastrin 15461 15200 17392 13649 18750 18176 20662 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-HSA-6807878.2 COPI-mediated anterograde transport 17957 67542 12068 54160 56494 16334 11733 11735 107338 66111 640524 20742 97484 20741 54399 233824 20743 56418 80297 224139 234663 66251 56447 54161 213827 11844 53334 68097 67511 77038 53598 56358 56389 59042 56444 67665 22428 56455 13191 12344 59288 56395 69654 228998 68137 105785 11843 11840 19324 66913 14275 12343 12345 100042773 11842 235661 74498 12340 50797 18195 108123 108124 70349 12847 76332 54130 16834 56041 13427 333883 102339 13426 13424 99412 76308 338337 20739 100042343 20740 PCP CE PATHWAY%REACTOME DATABASE ID RELEASE 96%4086400 PCP CE pathway 56436 17463 57296 20422 11848 26445 26446 19172 19173 56513 19175 19177 57265 26443 26444 19170 18643 66413 667035 22190 18751 59029 67089 93840 70247 22411 20187 105782 22417 66313 216869 106042 14367 14365 14362 14366 19353 11771 22418 11772 14370 208846 71770 14368 19354 14369 74325 22408 232910 11773 13542 21762 22123 19179 13544 19181 13543 19182 23996 19184 75788 18752 26440 67300 26563 19166 26564 12757 22419 19167 26441 18750 26442 170758 69077 66997 23997 DEFECTIVE SRD5A3 CAUSES CDG-1Q AND KHRZ%REACTOME%R-HSA-4755579.4 Defective SRD5A3 causes CDG-1q and KHRZ 57357 PHASE 2 - PLATEAU PHASE%REACTOME%R-HSA-5576893.5 Phase 2 - plateau phase 56808 54377 12295 12296 57814 246133 16535 66240 16509 57442 81905 81904 100986 54378 12288 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.5 Formation of HIV-1 elongation complex containing HIV-1 Tat 68092 433702 20922 20833 68705 98053 13871 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 58202 17420 67923 12572 27224 13872 27632 20924 24116 23894 12455 14884 13716 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 96%450341 Activation of the AP-1 family of transcription factors 26420 26414 16476 11909 19094 26416 26419 14281 26413 26417 IP3 AND IP4 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855196 IP3 and IP4 transport between cytosol and nucleus 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME%R-HSA-5619077.3 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) 214111 DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME DATABASE ID RELEASE 96%5619092 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) 236794 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME%R-HSA-2187335.6 The retinoid cycle in cones (daylight vision) 19661 20148 14539 12057 245532 19771 DEFECTIVE ALG3 CAUSES CDG-1D%REACTOME%R-HSA-4720475.4 Defective ALG3 causes CDG-1d 208624 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME DATABASE ID RELEASE 96%9619229 Activation of RAC1 downstream of NMDARs 19353 207565 640703 216963 55984 52163 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME DATABASE ID RELEASE 96%1236978 Cross-presentation of soluble exogenous antigens (endosomes) 56436 17463 57296 20422 26445 16912 26446 19171 19172 19173 19175 19177 26443 26444 19170 16913 66413 19186 19188 17534 59029 67089 70247 246278 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 14129 17533 66997 23997 HIV TRANSCRIPTION INITIATION%REACTOME%R-HSA-167161.4 HIV Transcription Initiation 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 96%2468052 Establishment of Sister Chromatid Cohesion 71988 71521 24061 100710 218914 67849 77805 20843 19357 13006 20842 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.8 Glucagon signaling in metabolic regulation 14702 14696 14527 14526 19088 19087 19084 104110 432530 210044 66066 104111 14700 14688 18747 14708 14706 14704 14695 224129 11512 14693 11513 11514 64337 11515 14709 18749 14701 19085 ZINC TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%435354 Zinc transporters 213053 214922 227059 72027 106947 69048 67547 22784 30791 230810 14977 239436 106957 72002 22782 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.5 Defective UGT1A1 causes hyperbilirubinemia 394436 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME DATABASE ID RELEASE 96%167238 Pausing and recovery of Tat-mediated HIV elongation 20922 20833 68705 98053 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 20020 231329 20021 69241 17749 100043714 58202 67923 27224 27632 20924 24116 12455 13716 FLT3 SIGNALING IN DISEASE%REACTOME DATABASE ID RELEASE 96%9682385 FLT3 signaling in disease 14389 12575 12402 20742 20851 20850 18712 50490 14784 14256 109181 667035 22190 360013 14255 19247 76007 224139 18176 20662 15461 14011 12048 18708 18706 CD28 DEPENDENT VAV1 PATHWAY%REACTOME DATABASE ID RELEASE 96%389359 CD28 dependent Vav1 pathway 19353 22324 12487 12519 12524 16818 224105 18481 18479 14360 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.12 G alpha (s) signalling events 17202 17201 20779 19087 19084 22094 12640 235036 18747 140498 212108 19773 381489 16336 319239 109689 216869 170458 19214 19222 19217 19219 14309 14308 100043254 14773 227289 17200 18576 11554 11998 11555 11556 12000 13492 382348 381853 14607 13488 14697 111174 215855 503558 54598 215854 19226 14710 15466 14699 11540 66066 14700 93896 14708 209512 14706 15566 22095 15565 12310 14704 14608 12922 15562 11516 16412 14695 23984 14652 241489 11517 12311 14693 110355 64337 218461 18574 14709 18577 18573 15874 110385 12921 238871 207728 16402 54611 12918 18584 14701 114640 223780 18583 54409 80910 19227 381413 19228 93690 56089 238725 213527 51801 71223 239530 14602 383563 14601 29863 11535 14761 14702 26385 14696 14527 76854 14526 19088 16866 16867 104110 14678 22354 14677 14687 22353 20287 14679 432530 210044 104111 22355 14688 70086 224129 320129 11512 11513 11514 11515 18749 18976 17199 11541 17203 242851 19085 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME DATABASE ID RELEASE 96%5693607 Processing of DNA double-strand break ends 70620 12566 667035 22190 107823 68251 20184 240087 66131 269582 232314 70681 70238 27223 56420 50721 107976 210766 21853 59004 22196 100043429 15204 19360 17535 21975 319186 27354 12021 319178 319183 19822 319182 81601 327762 12428 319190 22427 19718 69263 15574 319181 11920 12189 235610 319152 231724 237911 19355 225182 93765 26909 235559 12144 68275 106344 72151 68240 19891 12427 19367 19356 12649 78303 319188 15270 382522 DEFECTS IN TOLL-LIKE RECEPTOR CASCADES%REACTOME%R-HSA-5602358.5 Defects in Toll-like Receptor Cascades 17087 12475 22031 19697 106759 16150 18034 16151 17874 12229 434174 21898 20201 20202 266632 117149 53791 12491 21899 20193 12675 14161 18033 170743 18035 24088 21897 54445 110135 142980 99571 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 96%71291 Amino acid and derivative metabolism 21990 107508 13371 13370 70337 12389 19125 213696 114479 56189 107585 212647 12908 22094 214593 99439 13142 66811 106200 12640 70503 22018 11298 216343 15112 19193 11611 212503 217214 11898 50493 109900 227231 18408 18416 67824 11846 27053 100042811 72947 19301 93747 76282 100434 30805 229517 66885 12035 68682 12036 66948 58875 104776 12040 12041 13171 13382 12039 110695 218865 74129 192166 216456 22059 268782 21743 214580 20768 211006 50880 20226 14711 65967 75420 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 170442 20103 235386 668668 68133 56442 667739 192289 66194 71562 672214 69051 18478 23971 209027 66481 70266 23972 98256 225058 14204 209176 100038875 110391 11847 100038991 13180 100678 68028 66514 434437 100043000 53814 67891 12716 100043295 107766 622534 242669 238217 76722 54375 16785 26943 666669 12715 100040021 20810 67025 30956 100043391 230779 668182 671878 241053 75986 70789 432502 229905 56720 19989 194237 76808 217593 19899 108653 100043184 67432 19921 104174 19934 83885 100043755 102857 76238 27364 218442 319195 23923 100043209 20229 68193 209692 621100 67092 19941 574418 665189 270076 666899 12971 100042670 266645 107272 100039316 18247 22121 18242 18245 236539 56752 15930 18263 100043876 100043893 100043423 100042986 20115 107146 67281 76846 625646 100040298 68172 100042740 19951 15233 234724 15445 14085 667618 100040970 267019 56040 67248 100040331 67941 64918 246277 14874 66902 14261 12583 12411 57294 67870 211389 12709 12116 67873 243616 14719 14718 14645 66071 73748 107869 56369 104923 27376 246221 13166 211488 18948 22117 21823 56551 18104 13195 59010 226654 21762 22123 19179 238505 19181 11720 14660 19182 23996 210009 110446 19184 269378 26440 18113 19166 13190 19167 22293 18431 26441 22173 22178 26442 69077 66997 23997 56436 18293 17463 78920 57296 76507 78038 20422 71761 243382 26445 107239 227095 26446 15186 11992 19172 15109 72039 19173 243537 56357 19175 140483 67383 19177 14317 26443 26444 19170 66413 667035 59029 67089 70247 14431 104816 11484 269642 72560 240332 68346 14661 14411 234967 15108 15473 17254 107045 257635 226414 231691 97541 20539 216443 105148 231872 66143 20425 104458 78830 50799 85305 13722 RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.2 RUNX3 regulates BCL2L11 (BIM) transcription 56484 12399 12125 17127 17128 SIGNALING BY WNT IN CANCER%REACTOME%R-HSA-4791275.5 Signaling by WNT in cancer 225849 93687 26931 21770 26932 12387 21416 14367 72345 14366 22416 21951 74493 14370 56637 12005 14368 234130 73016 84035 56811 53627 73699 207742 19052 19053 51792 13017 13016 16974 13380 11789 16973 226849 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%3311021 SMAD4 MH2 Domain Mutants in Cancer 17126 17127 17128 HCMV INFECTION%REACTOME DATABASE ID RELEASE 96%9609646 HCMV Infection 20602 13626 18854 319149 12412 15077 13163 107305 52615 72543 27681 19646 70160 194309 52348 116733 73711 22088 67123 234663 330192 28084 21849 245688 16412 19386 13649 66914 66371 68097 68953 621893 234852 75608 319162 15267 319173 319163 15387 319168 319167 170762 108989 231042 227699 208092 223921 445007 227720 66700 319186 269113 66679 319178 18141 319183 319182 107939 69482 12609 71805 319190 21372 56455 54563 19069 319176 70699 72787 18226 319181 13712 218210 105513 81004 56310 15183 20185 69912 103468 14056 235661 319169 234865 59015 69736 78303 18033 319188 110379 13427 319189 13426 13424 382522 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%1660499 Synthesis of PIPs at the plasma membrane 101476 320207 320634 18710 19211 19249 104015 16331 16332 67073 77116 30955 18708 18709 18706 108083 74769 18707 18718 18704 17772 216724 210376 11840 240752 18705 104709 18720 18719 68365 18717 97287 12169 20975 74302 19341 53332 219135 84095 319934 271457 240753 231999 109135 19062 269180 234515 83435 83436 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME%R-HSA-6804756.4 Regulation of TP53 Activity through Phosphorylation 60599 12566 72119 667035 26416 22190 77976 13001 13000 100039026 19094 12795 22059 69181 20877 108099 19360 17535 21975 27354 12021 17248 17165 15257 81601 50883 23988 327762 12428 17246 241113 270627 22427 228980 19718 319944 69263 21374 15574 11920 20833 12189 216185 108143 235610 66464 231724 68776 237911 99730 19355 70439 20869 225182 26909 114741 235559 72504 15258 21343 12144 209361 226182 68275 106344 72151 24074 68240 19891 12427 19367 105787 19356 108079 20878 19079 63856 12649 108097 19082 12569 12568 76367 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME%R-HSA-917977.3 Transferrin endocytosis and recycling 242341 68775 76252 68428 11972 108664 66290 117167 94178 11964 110935 11966 100039636 66335 11973 11974 74915 338375 21871 73834 114143 66237 11975 22041 54411 27060 140494 22042 50765 15216 66144 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.8 Endogenous sterols 13116 110115 56050 11624 11622 17977 13072 13124 13079 17978 13121 13078 13075 13070 11863 11864 20181 20186 13123 104086 13122 102294 68165 14149 14148 18976 G0 AND EARLY G1%REACTOME%R-HSA-1538133.5 G0 and Early G1 75660 17187 12534 23834 12428 211586 13555 21781 12566 12447 21973 12448 19646 18538 13559 104394 17869 12427 13548 433759 19650 19651 17865 72568 12530 231506 629959 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 96%9006927 Signaling by Non-Receptor Tyrosine Kinases 20459 13448 11848 12402 18183 83961 100042150 12567 12443 11651 12566 12447 19303 667035 22190 12928 69710 12576 71514 13649 20218 13992 14815 170771 15251 140579 18176 15461 330662 19246 140580 232906 12223 12702 13874 19353 12927 15200 211323 13819 20811 66725 106766 93695 13866 75273 218397 20848 13645 DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 96%5579004 Defective CYP26C1 causes FFDD4 546726 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME DATABASE ID RELEASE 96%9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB 107351 16542 14011 668218 54214 ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 96%901032 ER Quality Control Compartment (ERQC) 193670 227619 54197 116891 20338 74126 66967 192193 223455 66597 320011 23802 22644 216440 66435 108687 75841 667035 22190 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 96%5663202 Diseases of signal transduction by growth factor receptors and second messengers 12387 20602 12402 74244 20779 17295 270118 109880 12005 26413 26417 20416 327826 109905 224139 56233 15214 54401 26395 26396 194231 54519 18176 29875 20662 245684 22371 15461 16416 75590 110157 23980 18218 14161 63953 21894 215449 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 328572 16706 12539 672511 21372 13191 81004 21812 21813 15183 20185 12914 640703 22084 14225 67605 15234 56484 16476 13017 13016 16542 66899 14011 668218 11789 12125 110279 18128 56438 13433 18595 70686 20423 14939 19164 19165 15208 100042305 208117 59287 100039623 56198 14235 18646 54167 232679 81910 13363 14367 14366 22416 54721 14370 14368 16147 18015 101809 114715 114716 23971 67561 12575 19645 21951 74493 12322 12323 108058 12325 12576 14255 14182 19047 19386 53627 73699 12015 12371 238037 19052 19053 51792 226849 225849 26931 21770 26932 17246 26420 211323 26419 56430 12608 12064 14388 18212 18205 107971 78405 18803 11839 13645 12048 67160 18011 13388 16449 240055 225164 11487 54485 11491 16450 16364 68705 98053 66420 69833 67710 245841 69920 76007 20022 20020 231329 20021 69241 17749 100043714 235584 67603 26372 56463 26936 21848 11774 330286 76850 67726 239528 100986 78781 19317 11610 76156 210106 66549 16905 236511 67095 14359 69923 338523 56717 216440 19353 75296 217351 56637 14256 214150 227743 19247 66753 104709 15170 116891 17454 20338 109270 20846 20848 606496 16818 56716 23797 78798 268980 13666 18183 215114 83961 320207 12211 100042150 19043 19084 22612 14025 11651 11682 11652 22324 12047 269523 18710 16153 17886 109181 14360 12988 234130 15213 73016 84035 17869 56811 13649 14184 21802 74126 207742 17096 244373 78757 76580 22160 30955 16974 18708 13380 18709 16973 18706 18607 74769 18707 12487 12519 12524 21416 68092 433702 16477 360013 16593 432508 67529 13047 19354 14534 19664 83490 18596 93687 77647 232232 18213 54214 70297 170787 18148 19211 16573 22059 108989 59079 56212 226861 20851 20850 18712 50490 14784 59069 19046 19248 70315 13866 107351 18519 15370 21803 667739 67300 17698 108147 20742 79221 15519 67384 17126 14183 17127 17128 67533 103806 333639 12223 71920 13874 15200 18412 17210 116849 21762 22123 12675 19179 19181 19182 23996 19184 26440 16653 19166 19167 26441 80903 384783 26442 22637 69077 14186 66997 14165 23997 14389 56436 16367 17463 14172 57296 80857 20422 26445 14170 26446 19172 14180 19173 14178 19175 14177 56458 67112 72345 19177 64654 21402 14175 14174 26443 14173 26444 14164 83379 19170 66413 26965 667035 22190 59029 13983 67089 70247 13982 208727 16399 14268 16154 58988 12478 264064 18591 17532 54601 56392 15185 15184 69162 51813 380928 17169 27267 15205 433759 16590 21787 15182 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME%R-HSA-428359.5 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA 319765 140486 140488 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%375281 Hormone ligand-binding receptors 16867 22094 22095 170458 12640 14309 14715 14714 16866 14308 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669926 Nilotinib-resistant KIT mutants 16590 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 96%6814848 Glycerophospholipid catabolism 50767 56209 68616 320981 66569 241274 233552 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2197563.3 NOTCH2 intracellular domain regulates transcription 270118 15208 328572 19664 18129 333639 14128 103806 15205 14939 PROLONGED ERK ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 96%169893 Prolonged ERK activation events 327826 18211 109905 77480 54401 26395 26396 107746 109880 12929 12928 18049 26413 26417 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME%R-HSA-5619068.5 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) 170441 RHOC GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013106 RHOC GTPase cycle 26934 110279 11848 66146 74159 21873 71409 12389 22319 11855 277360 192662 19299 70361 71302 22325 229658 12261 29875 19877 17207 52666 94190 263803 14251 22379 218581 84004 20166 21917 19878 56491 13830 109904 16480 18708 68743 20874 213498 56419 12704 243362 110596 56389 207212 19285 14252 59079 73910 223666 234094 98386 330914 50768 232906 71435 16801 228359 404710 13367 75547 20868 320795 109333 72754 208846 69632 268739 11853 17925 22042 329366 109934 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO PALB2 LOSS OF FUNCTION%REACTOME%R-HSA-9701193.6 Defective homologous recombination repair (HRR) due to PALB2 loss of function 12021 81601 327762 20422 233826 19361 114714 22427 19362 11920 12189 12190 237911 57434 19360 225182 26909 17535 21975 19363 19364 12144 27354 MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.4 MAP2K and MAPK activation 16706 171463 67836 20779 109880 26413 26417 545987 12988 109905 17169 83409 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 11836 109689 216869 110135 99571 22330 MPS IV - MORQUIO SYNDROME A%REACTOME DATABASE ID RELEASE 96%2206290 MPS IV - Morquio syndrome A 50917 AMPLIFICATION AND PROPAGATION OF COAGULATION CASCADE%REACTOME%R-HSA-9769743.1 Amplification and propagation of coagulation cascade 14067 19123 14723 11905 15160 109821 22371 14061 20720 268591 14069 19128 14058 14071 105722 14724 54368 14729 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH MUTYH%REACTOME DATABASE ID RELEASE 96%9605310 Defective Base Excision Repair Associated with MUTYH DIFFERENTIATION OF KERATINOCYTES IN INTERFOLLICULAR EPIDERMIS IN MAMMALIAN SKIN%REACTOME%R-HSA-9725554.2 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin 13645 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.6 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase 52717 99152 668450 229776 107995 217232 56317 59008 66156 56371 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME%R-HSA-435368.6 Zinc efflux and compartmentalization by the SLC30 family 22784 69048 230810 239436 22782 REGULATION OF PTEN MRNA TRANSLATION%REACTOME%R-HSA-8943723.2 Regulation of PTEN mRNA translation 233833 213988 236511 217351 19211 17454 214150 76850 239528 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 96%74749 Signal attenuation 16367 16334 14783 384783 16337 26413 26417 20662 20416 DEFECTIVE ALG2 CAUSES CDG-1I%REACTOME DATABASE ID RELEASE 96%4549349 Defective ALG2 causes CDG-1i 56737 RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9696270 RND2 GTPase cycle 13836 21927 214345 64652 232906 216197 11858 228359 67784 233877 381293 12389 83669 13510 11855 232339 208994 19249 75089 227937 67586 71228 93840 11671 327826 244418 229658 77480 105782 107971 16709 14269 218581 17063 269682 18708 19655 18709 53382 22042 18221 380664 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.4 Signaling by Leptin 20850 20848 16367 16846 384783 19247 16452 12702 20851 ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-HSA-418990.6 Adherens junctions interactions 233833 16451 20665 12388 232440 19089 12387 13200 13626 12550 319149 20586 20779 13858 15077 104836 13345 12558 21417 52615 19646 26413 26417 21418 22325 13001 13000 100039026 17869 245688 18109 209462 22160 16480 16452 22330 66357 224619 66286 228839 18550 18553 69019 93759 226970 56529 13017 13016 20683 330662 56198 140580 77630 11492 239096 11797 12385 59058 110751 12564 15426 66624 16201 330914 20613 12552 57875 15227 11798 54721 99982 76687 228913 11727 217734 99011 11735 19645 12330 20901 60611 16601 114142 16600 53325 17246 16193 12555 93760 13430 12561 21762 22123 19179 21844 19181 19182 67956 23996 71740 19184 105837 18033 58235 26440 19294 19166 94332 19167 15220 26441 26442 69077 66997 23997 54725 56436 17463 215654 57296 320873 20422 12565 24136 26445 241201 26446 12563 19172 19173 12562 19175 15376 19697 19177 12560 12557 12554 26443 26444 16195 22431 19170 21423 14694 75339 66413 192173 667035 22190 239857 59029 230738 18746 16194 67089 76007 56805 70247 21406 21885 58998 18554 227485 227377 75234 15267 319168 319167 13040 13030 76850 239528 319186 319178 319183 319182 236511 319190 319176 319181 19353 20014 213988 103963 217351 214150 69038 13135 20583 14056 18717 17454 319169 57377 20848 625328 78303 319188 15270 433759 624153 15182 16430 14376 382522 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME DATABASE ID RELEASE 96%75035 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 12532 100039786 50883 12534 12428 12427 54401 22628 22631 55948 22629 12649 22627 22390 PTK6 REGULATES CELL CYCLE%REACTOME%R-HSA-8849470.2 PTK6 Regulates Cell Cycle 20459 12447 12576 12567 12443 12566 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME%R-HSA-3249367.2 STAT6-mediated induction of chemokines 72512 56480 20852 MEMBRANE TRAFFICKING%REACTOME%R-HSA-199991.8 Membrane Trafficking 193813 270160 12068 70785 317717 235633 56494 192232 60409 211922 89867 67443 225870 58194 235416 329260 216131 69440 20408 67231 19328 12402 66890 12663 56324 217449 15239 20404 20844 20405 13858 12874 56044 117197 245638 27059 18457 224139 94245 80912 11777 170760 54401 20615 21987 232946 20661 77929 67804 69178 12848 17920 109689 216869 100043806 26891 56444 67665 22428 13191 12121 76895 12344 238055 18476 59288 18475 105785 22365 64930 18002 14325 640703 22084 216705 14319 20980 22041 22318 22627 20979 11820 99412 22042 26934 11555 66397 69608 218811 320634 99683 20619 243764 77371 20334 56447 54161 66371 68953 75608 208092 12836 66700 59042 100017 76877 17918 56395 14366 76709 73178 22418 105513 11771 11772 11650 71770 56443 68137 66913 68089 67771 56378 66713 232910 74117 11773 16835 50797 70349 12847 13543 17913 54160 108148 66111 54399 75612 217615 104015 73470 16563 234663 77980 213827 11844 53334 68097 73804 14269 67511 56358 214459 14799 56455 26951 229841 75985 68938 228850 19325 68328 18472 57915 20528 210789 68365 74741 235661 18195 110379 13427 11839 19157 13426 13645 67474 19159 13424 19158 228421 72318 27277 73124 11998 12000 21872 240641 269152 16565 16564 16552 11891 16580 16581 67023 16561 16562 72772 16558 70218 20932 75050 16554 286942 71116 16578 319991 224630 16560 11774 26754 241113 69654 71648 17274 19353 53413 11843 20336 107371 16569 68449 108079 381605 67046 19079 54130 100855 14423 105504 19341 108097 56486 211446 108995 77407 19337 269589 102058 74105 224617 19082 260302 235442 233204 17158 56715 103724 23797 19338 209815 93739 28169 22241 54189 227800 69940 66687 207592 16570 19326 70296 107338 106039 22628 215114 11651 66482 11652 53357 338366 17886 109181 107305 72543 27681 70160 194309 52348 116733 73711 16568 22088 67123 330192 28084 76959 53869 66201 13649 20479 12500 21802 66914 55948 12502 12638 12504 53598 108099 104318 16594 668303 16579 232943 19348 216363 71819 16593 16551 110033 13047 209737 74764 76932 73296 108123 108124 16004 74375 76332 16834 14609 226089 14619 76688 270192 19345 53611 271457 56367 19344 319642 102339 19346 98910 58244 70646 78304 338337 104303 17957 67542 78689 242406 56382 53330 228960 69834 224705 76899 245944 97484 68505 233824 54214 12662 232286 68299 22319 227746 70297 19349 56418 70361 100039786 16572 66251 16573 16443 56389 66905 14615 14610 14617 20909 12343 12345 11842 12340 16571 319934 67300 13429 12757 20739 20740 74947 11733 11735 640524 20742 20741 20743 103967 80297 19339 11607 12223 71920 13874 20508 15200 21336 22320 26893 17113 14533 13423 11840 74325 26894 15481 67489 20955 11766 108679 11781 108011 215890 74438 105245 64138 13430 11782 26572 72685 26895 16334 74018 667035 22190 18783 110355 77038 11768 11769 108012 11764 11765 11767 252903 14618 20912 13132 13043 73094 229521 194590 210108 233489 80718 218503 30931 228998 18704 30934 14621 74015 225152 13854 353155 66691 17155 14613 67091 108800 17156 14612 20703 80708 230815 14611 66226 66616 14622 19324 240028 20616 14620 105522 20403 14616 243819 13855 14623 14067 231580 118454 69162 11845 75964 14275 67602 270096 12793 15463 217835 67857 18717 14569 100042773 29816 66975 20333 56017 14567 215474 218038 72433 207352 30948 227801 74498 13859 102442 22631 66682 320129 76954 52036 12492 106572 22629 76983 60510 19347 13032 269774 229541 245828 23969 72121 12794 20975 67790 240667 106628 72825 67727 14725 320714 214895 16197 216344 59005 55925 67844 14069 66147 74760 78232 23970 245886 56041 170625 320560 333883 54609 329727 21787 56085 320435 27096 226407 72978 105841 227648 19330 76308 74030 76510 329877 100042343 209773 50907 192236 DEFECTIVE DPAGT1 CAUSES CDG-1J, CMSTA2%REACTOME DATABASE ID RELEASE 96%4549356 Defective DPAGT1 causes CDG-1j, CMSTA2 13478 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 96%5654736 Signaling by FGFR1 14172 80857 14180 12402 14177 67112 24064 64654 17346 14175 14174 14173 14164 71436 109880 667035 22190 19247 26413 26417 327826 399558 116701 396184 114715 114716 18176 14388 20662 21814 15461 19052 67903 107971 19053 51792 18803 18708 14165 18706 SARS-COV-1 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME%R-HSA-9735871.2 SARS-CoV-1 targets host intracellular signalling and regulatory pathways 328572 100039786 20683 54401 22628 22631 55948 22629 17127 12389 17128 22196 22627 67089 18607 SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.8 Synthesis of PIPs at the late endosome membrane 18704 234729 225326 54384 170749 17772 103199 77116 210376 75669 18711 RHOD GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013405 RHOD GTPase cycle 26934 214230 208263 70497 12389 18844 70598 22319 241656 11855 19349 68428 70361 71302 229658 13726 68917 23943 27360 75415 52331 218581 84004 21917 56491 66871 18708 18709 218756 56419 70804 380664 11736 56320 109711 223666 83397 69922 98386 434204 330914 232906 76763 71435 228359 13367 11854 27984 235611 12345 16906 ABACAVIR ADME%REACTOME DATABASE ID RELEASE 96%2161522 Abacavir ADME 20518 75894 20517 26357 20519 18671 76952 18534 GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME%R-HSA-881907.3 Gastrin-CREB signalling pathway via PKC and MAPK 20111 17392 13649 110651 18176 20112 20662 15461 15200 14459 12426 23939 18750 26413 26417 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428559 Proton-coupled neutral amino acid transporters 246049 215335 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951911.2 RUNX3 regulates RUNX1-mediated transcription 12400 12399 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.3 Signaling by Overexpressed Wild-Type EGFR in Cancer 15200 11839 13649 21802 13645 12223 71920 13874 FORMATION OF LATERAL PLATE MESODERM%REACTOME DATABASE ID RELEASE 96%9758920 Formation of lateral plate mesoderm 16147 14463 12159 15227 20423 MPS IX - NATOWICZ SYNDROME (CS DS DEGRADATION)%REACTOME%R-HSA-9953097.1 MPS IX - Natowicz syndrome (CS DS degradation) 15586 SARS-COV-2 MODULATES AUTOPHAGY%REACTOME%R-HSA-9754560.2 SARS-CoV-2 modulates autophagy 233870 77573 233405 67443 78610 269338 228545 22365 71732 218035 80743 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.2 Biosynthesis of DHA-derived sulfido conjugates 17001 14865 HDL REMODELING%REACTOME%R-HSA-8964058.4 HDL remodeling 16891 11806 11813 11307 11657 11814 11816 16816 AMINO ACIDS REGULATE MTORC1%REACTOME%R-HSA-9639288.3 Amino acids regulate mTORC1 17168 216805 101142 230676 270802 98402 268933 56032 72124 71962 216742 319481 101148 277854 252875 70394 56717 242341 68775 140742 66508 76252 545987 11972 108664 66290 54170 11964 52187 68576 110935 66096 11966 83409 100039636 74370 66335 68441 11973 11974 268706 74915 338375 245670 73834 114143 66237 230784 110379 27060 56716 66144 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%416700 Other semaphorin interactions 16412 83433 18845 67784 20349 140571 20356 18844 22177 20354 20358 109700 12517 243743 54712 20361 19264 214968 20351 BETA-KETOTHIOLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9915355 Beta-ketothiolase deficiency 110446 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%168256 Immune System 21943 53381 70450 12654 56208 13014 102595 170813 14190 12796 76905 20892 67912 53328 71728 76025 229574 12508 12514 78892 68724 26949 232413 27261 433375 235627 19074 19271 18126 19263 18103 72461 17523 70152 52633 217353 22436 19276 22325 69981 667301 231887 72042 69660 71869 72065 100042069 394252 78388 23917 21946 16970 57257 227960 67689 74287 19877 223978 100037283 11571 208795 380924 11465 14600 245126 19116 20568 216233 383295 12700 241197 22352 67213 18813 83768 69189 218978 18703 268379 15516 107767 100040018 13244 66892 93726 54159 56318 12609 55950 17395 70536 100040603 21930 20195 212114 53856 18600 11593 74039 73690 56016 545878 16783 80796 16172 54672 108888 18550 17064 56031 11605 66222 69550 96979 12283 13861 20972 71517 69537 381812 66508 14667 545987 16678 80860 13684 67862 66612 28185 20409 74012 208643 19288 76299 66060 14824 83409 18521 13690 22318 20614 20907 24088 21897 14469 257630 23845 66397 171095 69608 15006 218811 99683 68981 240095 667803 14991 77371 23806 55932 20334 21899 53379 98758 16176 12362 12363 22195 50873 17002 16396 236573 12370 230861 19766 11797 56532 16173 22030 16363 56424 67245 69146 11796 14827 50701 53378 16175 54722 434174 14082 13205 246728 16171 19260 15526 22210 269717 109305 12322 12323 108058 12325 19249 19250 20866 19253 104831 19259 229709 19256 16438 16182 16439 24058 16068 18747 320139 56294 19255 117149 12491 73914 18125 20193 16440 110651 20112 18383 26377 21935 620235 240873 24099 19695 22166 57916 22163 22164 245527 18489 12652 16429 77799 18843 326623 19194 78416 171211 228801 57757 242100 20491 72049 85030 50930 26399 11927 21944 20293 21934 26400 27279 80898 21940 26398 21941 26420 21949 26414 259301 26397 21948 228796 76113 17000 16994 11758 16992 75526 384997 23939 13608 13607 21942 16193 667310 15977 26419 18803 19294 12043 12048 13629 11487 11491 16195 18746 19225 11689 15139 14962 12263 12266 625018 12265 80876 74735 22329 19824 23960 225467 67781 65972 229900 232714 246727 56045 17318 56417 71884 231655 93679 66141 13665 224762 67204 286940 67525 58185 26905 70110 211948 15512 15482 54139 57444 52668 67513 67030 55992 667370 101700 112419 15958 76500 101831 24014 13653 15061 104806 94088 80890 360213 20617 56631 16391 226641 71885 22670 319236 14087 15894 214158 229644 100040608 237211 15900 72775 229898 66854 60534 71955 57437 108995 19089 53357 16153 17886 71481 211550 55948 67731 14751 22160 12772 12768 12458 13038 18386 13039 12702 14462 16854 16477 14293 12765 227288 16880 19156 57349 20303 20304 20292 20302 20297 100039973 20299 18148 19211 16184 16183 330122 14825 19246 23988 19258 14229 15945 57743 17534 21354 21356 21355 93836 53421 20909 100043039 246278 66212 12343 12345 57264 12340 21858 21857 11783 69562 18854 66105 80751 11350 17127 66313 58992 16621 17131 19885 22608 268973 75788 16653 12981 12978 56458 16179 18390 16408 14127 16181 16878 14128 21937 21938 16178 12366 16160 16401 16159 16155 16154 21926 12985 56338 56508 223864 12053 20716 12359 227290 117586 15978 12843 18613 20911 12512 83814 104009 11625 20527 74145 12631 14088 94175 22339 18407 71393 20586 21936 433766 107568 29875 110157 13169 14161 215449 16452 110135 99571 22330 16993 13191 242341 68775 15369 76252 11972 108664 66290 14325 11964 110935 11966 100039636 66335 11973 11974 74915 14319 338375 21871 73834 114143 66237 11975 27060 16819 77674 140494 654464 266620 654459 75400 66144 246700 71902 246082 654460 654465 244332 56480 629114 446099 54131 207521 58203 16885 74256 21929 67963 18453 11771 11772 71770 232345 218203 381925 18807 71910 50931 50926 66162 18569 12798 18738 232910 50498 11773 12931 11632 20849 209590 18826 17319 18788 16162 16161 18749 246779 16188 16185 15926 12984 12982 16192 16191 109754 11676 14387 14595 75612 110078 110095 20969 18436 15442 50917 16189 16163 16174 93871 12505 19373 19374 53603 16196 57914 212032 77559 66681 231507 19325 68365 21351 100038891 18641 16170 20908 76527 109658 19152 19283 242700 76507 18648 17159 110173 225913 27357 15898 16409 16421 72157 16423 16411 16414 78369 232449 11674 12475 22031 56489 225471 106759 21353 71648 14256 18950 11717 17390 11821 17161 13666 19043 56468 54607 76501 12238 16198 16199 74125 83490 77647 21682 16923 11848 19698 15896 73086 170786 22319 13010 51788 19349 18805 22139 52588 11870 22072 544963 16572 16573 16412 140579 17380 16790 94176 330662 70495 52331 20430 17079 16803 329547 17084 56212 13350 16592 12306 16410 14083 11352 71745 17925 14026 17973 20663 12331 22323 331461 19025 18010 216197 16190 69677 100042555 13712 16156 83995 17984 18412 107527 16165 16164 14086 26406 22320 19229 56708 77125 50905 11840 18413 329244 15481 17210 237310 20955 213208 237313 54450 60505 338374 93672 105245 58181 64138 60504 13430 116849 215274 69581 16169 16168 140806 17082 18414 53314 54473 218624 14873 215257 234836 13019 230828 57890 12804 12803 54448 384783 75669 81897 14389 16367 225326 14173 216445 16194 70719 12986 117589 78541 69299 218215 94090 233902 69116 208650 73998 50760 20821 235320 242521 209239 74492 75234 66799 72194 67845 15204 69706 235439 57751 140630 94091 217194 16924 22019 226541 65257 104184 23912 19820 78913 242785 56791 68729 69010 211949 66743 233040 76763 231672 18744 50492 224826 231863 101358 12449 224023 109161 22193 71538 76375 67455 14794 217217 71999 76577 269529 83962 230654 635668 240028 66515 269514 78889 68431 230904 28105 71865 14569 380928 50868 207215 22200 627648 207304 75717 106572 70294 67921 100041484 22192 66663 142688 243574 321006 268291 209200 74646 448987 22346 56736 228003 12703 19330 212919 54484 20439 218793 20437 636931 328234 76608 19823 227738 74153 22201 79263 22209 74244 53323 140629 68497 70620 330369 23807 140499 59009 17237 50788 22213 67128 22222 224938 22214 17999 98766 67615 19155 268470 67588 59026 230903 66772 208372 76454 70093 329152 117146 65247 22215 65255 67345 81018 84585 217342 142687 209462 78910 231380 65256 70392 69807 244421 22036 224170 240396 225055 17025 24105 232539 56515 170823 215061 67138 19822 74132 67490 231670 672511 56444 226098 67665 69754 22428 224619 77113 14897 12344 59044 207952 59288 70348 18475 320118 170737 70928 56228 30843 68854 76294 211007 72323 399566 30945 68098 100763 214931 19264 83433 108015 15234 22177 50884 83767 110351 329165 26934 105855 242687 17969 11308 20619 13058 13057 108100 17970 101314 17972 12261 56485 19164 59287 15162 12526 140580 234779 17918 12267 76709 73178 20963 12229 56443 19200 80987 68089 67771 11867 54483 56378 66713 74117 245880 14191 22376 215280 18439 68524 67955 13035 17882 14129 17913 246256 14131 17909 66824 330319 216799 76884 14302 16186 16331 16332 104759 74096 192656 17874 17258 20203 20210 24110 257632 26940 266632 26401 80750 223664 53791 107607 69721 231130 93834 270151 11596 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 69654 104112 16569 54130 16570 66848 66557 16568 53598 210710 22154 380711 20469 18127 16594 668303 16579 232943 13036 13034 19348 229445 67065 56464 71819 74414 226977 16593 16551 110033 78929 280408 16149 209737 74764 26939 15002 67486 15001 70408 64291 20018 16768 69870 15000 70428 14998 218832 67005 20016 12909 16004 319642 19346 66369 80910 192176 20851 20850 18712 14784 13033 18986 16571 18016 13429 17698 20740 74947 20743 103967 17967 269116 72269 19339 13002 21762 22123 12675 52440 108723 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 18037 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 13682 19177 13681 21402 16150 26443 26444 16151 19170 19696 12042 66413 26965 667035 22190 18751 240354 59029 26409 67089 103583 70247 56469 19883 18753 22196 170743 13040 19141 170744 13030 17535 22027 54445 142980 667277 239447 317677 14134 17195 12944 11537 16904 12259 71693 12260 12262 14783 19090 384309 22040 383619 72162 72935 72512 54123 68891 20852 268857 22596 13211 14375 214763 20703 69162 56619 332579 20333 26888 56644 381809 17312 56620 17474 13032 245828 217232 56317 59008 66156 216080 69957 333883 17222 68612 52563 22194 68999 52206 100039535 99152 668450 12534 12387 58194 12550 12402 20779 20404 107746 12929 26416 12928 56044 18754 26413 26417 29857 20416 109905 19094 102626 54401 26415 26395 18176 20662 15461 17164 11846 13830 16480 13505 328572 15129 17087 15368 19041 238055 13367 20868 30960 17260 21898 18024 12914 11909 640703 268373 19055 19056 19419 18018 18019 240168 19058 14225 18021 20656 26458 56484 16476 113868 16906 668218 11820 12125 14103 12333 68682 56438 67526 11793 54644 12182 16201 58222 26364 16453 16177 54721 13609 20847 15980 17060 15979 12518 15985 15975 110606 26554 14272 211255 19342 19336 70349 110006 15212 12091 11881 12575 12567 18793 12443 56371 27401 227753 12576 14255 73470 16563 234663 19386 140792 109154 73699 11799 12371 19340 68097 19052 73804 19053 51792 66934 445007 226849 225849 26931 21770 66902 26932 56455 71665 229841 107995 24015 69912 70568 103468 235661 234865 59015 69736 216238 71398 27056 78287 110379 266692 69928 13427 14828 19128 13426 217303 67474 13424 228421 17533 19109 11687 13510 16364 15439 12367 18772 109620 11891 66420 69833 245841 20932 17749 11977 100043714 21679 15267 21676 319168 21678 319167 14281 224105 50770 226144 105722 547431 75778 238555 76850 237754 239528 195349 319186 12231 21677 11980 319178 319183 319182 193670 54197 236511 319190 26754 241113 14282 56717 70377 319176 76295 18034 216440 319181 19353 20014 213988 57261 103963 217351 56637 214150 69038 227743 13135 19247 13819 14969 14968 66753 104709 67819 208154 14056 15170 116891 17454 20338 235606 319169 223646 109270 50723 67075 105787 67512 108079 20846 19079 20848 108097 625328 78303 319188 210992 15270 58205 16818 19082 80286 56716 624153 68292 216134 23797 16430 382522 233833 53859 16451 21415 232440 18806 13200 13626 319149 72297 22628 320207 16478 16842 22612 11651 11652 12483 22324 15077 269523 66310 18710 140858 97064 20719 18566 11886 230979 21417 18792 52615 26410 19646 213464 14360 12988 11910 22165 214162 13001 13000 100039026 17869 245688 20747 12500 22601 12501 12502 15251 17096 23808 12504 18109 244373 18005 16784 17444 78757 228775 60533 17750 76580 108099 16362 30955 12774 18708 18709 18479 12477 18706 18607 74769 18707 66357 12487 12519 12524 21414 21416 231051 17394 18481 19354 20201 20202 240047 11501 67923 71586 230073 66641 71956 228607 217069 19345 21454 19344 19261 106052 108078 242960 12346 20343 30838 13052 12469 270152 12461 58217 30050 50762 227613 50754 11461 668101 232801 30925 217304 26904 14130 217306 100043861 213980 16641 16643 232790 68628 16498 71326 50928 52685 22059 75345 21947 57781 17086 50789 231805 170741 84544 30839 243958 243864 54215 75863 629970 20698 100038830 52855 170762 328833 108989 83382 231042 246746 227699 20612 223921 319352 227720 27007 269113 54698 66679 18146 18141 12480 20400 107939 12525 69482 225825 71805 224840 17470 140497 23900 54563 16646 19069 70699 72787 94212 18226 218210 16419 16952 19248 55991 269328 17829 21803 18636 100039649 140474 224116 67300 12757 17063 73732 353328 12317 100038882 56615 193740 12330 15519 16211 100039592 16648 19106 100037258 19204 68197 381686 16649 14289 667618 20813 12143 17392 72621 14061 22361 100561 385643 107829 192170 16822 22637 16797 630146 23880 16428 56743 227394 20674 23992 21357 22063 18173 28240 11883 14126 14125 16776 14268 69583 22370 230558 15007 319430 12010 12258 195046 11768 110382 11769 12478 108012 12520 11764 69379 12279 11765 50702 11767 12628 252903 71756 12759 12630 93721 12273 16912 12274 19171 545366 17221 56373 12902 109828 16913 19186 19188 100041766 216150 66513 93765 66589 18761 22034 19395 66724 233046 68652 52120 20111 22631 16197 18976 80861 108086 12977 224794 67706 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.4 RNA Polymerase III Transcription 18027 18029 20823 18032 21374 67065 71752 74414 233863 66420 72308 69833 66596 227644 78929 245841 66653 544971 77634 70239 20841 18986 269252 102209 26939 330959 67486 75627 70408 20018 69870 70428 67371 17749 218832 100043714 67005 20016 98488 12909 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 96%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 12914 12400 18751 12981 16854 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.7 Cytokine Signaling in Immune system 21943 12534 56208 19823 74153 12402 20892 20586 20779 107746 21936 12929 26416 12928 19271 56044 18126 17999 26413 26417 20416 19094 102626 26395 18176 20662 15461 17164 110157 11465 14600 19116 215449 216233 12700 22352 16452 66892 15368 12609 17395 16172 18550 17260 69550 13684 11909 208643 268373 15234 20656 56484 13690 16476 16906 22318 20614 20907 16819 11820 12125 14469 14103 257630 56480 54131 171095 56438 15006 68981 240095 667803 14991 23806 55932 53379 98758 16176 12362 15162 236573 12370 230861 11797 16173 22030 16201 16363 67245 69146 234779 11796 18453 16453 16177 54721 16175 20963 13609 434174 20847 15980 17060 15979 15975 246728 50931 50926 110606 16171 66162 18569 12798 14272 18738 50498 12931 11632 20849 209590 18826 17319 18788 16162 16161 246779 15526 16188 16185 12984 12982 16192 16191 13035 14129 12575 12443 12322 12323 108058 12325 19249 16186 19250 19253 12576 104831 14255 19259 16331 19256 16332 16182 24058 16068 18747 320139 56294 19255 12491 73914 19386 20969 73699 11799 110651 20112 18383 16189 21935 16163 19052 16174 240873 24099 19053 51792 57916 22163 93871 22164 19373 245527 12505 19374 53603 16196 57914 77799 445007 326623 226849 171211 21770 66902 20491 72049 85030 50930 21944 26399 21934 20293 27279 26400 21940 21941 26398 21949 26420 26414 21948 26397 17000 16994 16992 13608 23939 24015 13607 21942 69912 16193 667310 103468 15977 26419 234865 59015 69736 27056 21351 110379 69928 18803 100038891 14828 12043 12048 16170 20908 76527 19109 109658 19152 19283 242700 11687 11491 16364 16195 12367 192656 17874 17258 20203 20210 19225 24110 11689 257632 266632 80750 223664 107607 69721 231130 12265 93834 80876 270151 74735 16409 11596 22329 67454 19824 240518 23960 71966 225467 108960 67781 59025 65972 16411 100040260 229900 16414 101568 246727 235584 56045 67603 17318 319520 56417 72349 231655 93679 66141 224762 14281 13665 286940 224105 67204 67525 58185 70110 26905 211948 15512 15482 54139 57444 52668 67513 67030 55992 667370 101700 112419 22031 15958 76500 101831 24014 13653 18034 15061 104806 94088 80890 360213 20617 56631 16391 226641 14256 71885 22670 319236 14087 15894 19247 214158 229644 14969 100040608 14968 237211 15900 72775 229898 66854 60534 15170 17390 20846 20848 16818 23797 53859 16451 17161 319149 13666 19043 22612 11651 11652 22324 15077 18710 16153 71481 211550 21417 56468 230979 26410 14360 54607 12988 17869 55948 15251 17096 12504 17444 17750 22160 12772 16362 12774 12768 18708 18709 18706 74769 18707 210710 12519 18386 12524 12702 14462 16198 16199 16477 14293 16880 67923 71586 230073 228607 217069 21454 12346 21682 16923 20303 20304 19698 20292 73086 20302 20297 100039973 20299 18148 11461 16184 16183 330122 16412 66369 22059 21947 14825 19246 20698 170762 108989 231042 227699 192176 223921 227720 269113 16803 66679 18141 107939 23988 69482 71805 19258 54563 16646 19069 70699 72787 20851 18226 20850 218210 18712 14784 14229 16952 15945 19248 20909 18986 12340 21857 12306 17829 21803 11352 17698 17973 18854 100038882 20663 66105 193740 12330 17967 331461 15519 16211 100039592 16648 19106 100037258 17127 19204 381686 16649 17131 667618 17392 16190 69677 100042555 13712 16156 83995 17984 18412 107527 16165 16164 14086 26406 19229 56708 19885 77125 50905 11840 18413 329244 15481 17210 237310 20955 22608 213208 237313 54450 60505 338374 93672 58181 60504 116849 215274 69581 21762 16169 22123 16168 12675 140806 17082 19179 18414 19181 53314 19182 54473 23996 218624 19184 14873 215257 18033 234836 26440 16653 13019 19166 230828 18035 107829 57890 19167 12804 18036 12981 12803 26441 192170 12978 54448 384783 26442 69077 66997 23997 12234 14389 56436 16367 17463 57296 20422 26445 26446 19172 19173 19175 56458 19697 13682 19177 20674 13681 21402 16150 23992 26443 14173 26444 21357 16151 19170 66413 26965 16179 667035 22190 18390 59029 26409 16194 67089 103583 70247 12986 56469 19883 18753 16181 16776 20821 16878 14128 21937 21938 22196 16178 14268 16160 16159 16155 16154 69583 21926 12985 15007 12010 22027 12053 15978 12843 56791 20911 14783 16913 54123 20852 19188 100041766 13211 66513 93765 66589 22034 66724 74145 68652 12631 20111 14088 22200 22631 75717 22192 16197 18976 216080 22339 12977 12703 22194 SHC1 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 96%180336 SHC1 events in EGFR signaling 15461 15200 11839 13649 21802 13645 12223 18176 71920 20662 13874 20416 PHOSPHOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 96%1483257 Phospholipid metabolism 114874 28169 68262 66659 18806 55979 225010 18778 14792 329502 320207 66857 271844 67452 237625 665270 66853 270084 53357 67216 68255 232889 18710 225845 13001 13000 100039026 30955 18708 18709 18706 108083 74769 18707 66826 271457 100434 213603 242259 70129 68682 64436 320634 14732 19211 18805 23945 18718 64899 215456 14245 234729 54384 17772 320981 64898 216724 13350 18807 210376 66569 241274 99138 240752 18705 234129 67800 50767 14571 18720 68616 18719 97287 233315 11842 106869 107650 103199 244882 18711 12169 233552 268783 69769 74302 53332 219135 84095 319934 240753 101490 231999 109135 19062 269180 66443 234515 83435 83436 101476 56209 170749 19249 104015 16331 16332 83493 77980 67073 104759 224020 77116 97212 231086 12038 12647 11423 219024 99712 236899 12651 237928 79196 56018 11840 237542 212862 28042 12660 70568 13026 85031 76574 74182 106861 105501 18559 27281 18618 102278 68365 67078 71760 74451 12891 75320 66461 68671 218121 226856 245532 320951 66586 668257 192654 74486 56305 116939 66727 266692 110911 75669 225326 19210 27388 76768 18783 69923 18739 18704 74596 19679 327958 52858 104709 18717 77582 67512 14712 18779 239759 20975 26971 333433 19341 108958 99010 210992 14555 26970 26565 215708 102247 18784 18782 78390 66350 231510 52123 DEFECTIVE F8 SECRETION%REACTOME%R-HSA-9672397.3 Defective F8 secretion 14069 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 96%3781860 Diseases associated with N-glycosylation of proteins 102580 24070 208211 381903 227619 13478 328370 18010 19025 14595 57377 217664 207958 56737 320438 12091 66789 208624 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 96%83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 71279 13340 269346 56327 11739 63959 434203 433923 11740 114304 107566 243328 NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-HSA-375165.5 NCAM signaling for neurite out-growth 13004 640524 20742 20741 73086 20743 17967 26413 26417 14360 80297 12830 11603 12829 12828 12827 12826 18176 20662 12841 15461 12840 245026 12839 12835 20450 12834 58226 12288 12833 12291 239556 14573 20452 12295 12296 12297 12298 14586 19122 14585 19197 14588 19262 12292 12289 21367 14083 18188 20739 20740 11876 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME%R-HSA-5619046.4 Defective SLC26A4 causes Pendred syndrome (PDS) 23985 RHOQ GTPASE CYCLE%REACTOME%R-HSA-9013406.5 RHOQ GTPase cycle 233071 216963 66894 70497 12389 68146 22319 20619 11855 277360 260409 263406 19349 26431 70584 68428 328232 71302 229658 104252 16443 75739 12638 29875 217866 105782 94190 14269 218581 56699 66871 13830 224105 226751 16480 218756 18479 56419 104445 14270 330914 50768 232906 94221 71435 228359 404710 73178 20514 66508 54126 106628 14609 71709 22042 236915 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.2 The AIM2 inflammasome 12362 66824 383619 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME DATABASE ID RELEASE 96%9679504 Translation of Replicase and Assembly of the Replication Transcription Complex 68953 105513 75608 56208 67443 225326 78610 208092 75669 66371 66700 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 96%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 12367 670717 11783 66593 12371 11798 12369 SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.4 SUMOylation of DNA damage response and repair proteins 66341 67241 66647 67872 18854 68501 226026 11545 240087 70238 56233 56469 19365 19386 59004 20610 20842 12418 22196 108138 100043429 15204 170762 24061 108989 231042 227699 223921 227720 445007 269113 19357 12151 66679 22658 18141 107939 19763 69482 71805 54383 54563 13619 19069 22427 70699 241915 72787 12416 18226 218210 12189 26370 19821 69912 12144 12578 13006 68275 103468 22591 234865 30951 59015 69736 110379 20843 67711 SPECIFICATION OF PRIMORDIAL GERM CELLS%REACTOME DATABASE ID RELEASE 96%9827857 Specification of primordial germ cells 18999 12159 100038891 13813 12767 20671 12142 14726 21420 214133 244551 12396 SIGNALING BY INSULIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%74752 Signaling by Insulin receptor 14389 16367 14172 80857 18576 16334 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14255 26413 26417 20416 327826 15925 18176 20662 15461 19268 228775 19246 18708 75778 18709 18706 18607 74769 14783 16337 14256 242341 68775 13033 19247 76252 11972 108664 66290 11964 110935 11966 100039636 66335 11973 11974 74915 14388 338375 21871 73834 114143 66237 11975 54411 27060 80903 384783 140494 75669 14186 14165 81897 66144 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702614 ponatinib-resistant FLT3 mutants 14255 METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.9 Metabolism of lipids 20602 23989 12389 66853 16922 18631 12908 17117 68801 67528 21835 74114 14311 12640 110959 13075 14081 228061 56185 80911 28077 13850 12012 111175 20186 13123 171285 93732 104086 20280 13122 77337 67689 208665 171210 101502 83702 17164 56794 67224 19014 229003 11655 11865 66999 13244 328572 16993 15446 13106 21372 109151 11624 11806 11622 72303 17977 107141 73690 19017 13077 18143 56448 13076 30960 13114 17978 59035 66826 81004 13110 66993 11605 96979 24001 12753 27413 15183 14667 20185 217166 66612 12914 56406 26357 108098 18670 74147 28253 171282 11666 26458 15488 113868 170789 26378 66172 192191 78334 73166 231070 270669 110196 100434 14137 213603 100040592 242259 20683 66397 70129 18044 68682 18045 20933 18046 235293 68603 69608 218811 14732 320634 99683 20775 20249 235623 67131 192156 15484 170439 15483 72999 12401 13121 20788 13360 107476 100705 14593 381379 16987 71949 17764 75292 56453 101540 77371 67630 319554 230379 17855 239559 20334 67219 53897 76893 66190 432628 74442 66183 171168 338521 20773 77626 26879 22234 14421 545975 14420 241447 104725 66844 56632 19012 50784 22239 18760 74411 238011 74754 230101 66234 433323 18194 70059 110460 76199 208449 68865 54447 13595 67260 15490 67916 100017 17001 227102 268656 228677 93898 242083 223753 57875 81535 70750 20397 76303 22259 71720 228983 12642 65969 15486 11303 66065 114664 14187 66113 99031 71240 105349 100273 20520 11657 18807 11807 11684 20859 18749 15485 14598 319446 70893 15212 15211 23887 12091 11677 11881 13479 244757 108105 50935 19249 104015 16331 16332 18747 19047 12491 83493 77980 67073 104759 224020 77116 76408 14775 56336 70316 56386 17436 20524 13070 79196 237542 28042 70568 85031 107765 74182 12896 105501 12895 27281 68041 102278 19224 68365 67078 66198 71760 264895 74451 77219 12891 14200 75320 12408 66461 14073 68671 66834 218121 18979 226856 67420 245532 320951 57279 66586 330260 668257 269823 192654 70025 74486 243168 56305 116939 71985 66727 52538 266692 72482 110911 11688 78245 69573 54218 64292 102632 68680 14373 66469 228859 56360 330450 94185 171281 67103 74156 320997 245533 13120 13167 11690 223722 631304 329910 11687 195733 13118 72054 17250 19210 208285 27388 21391 19223 13124 100042622 76205 59045 12257 170459 20845 19225 11689 110821 66904 76768 17850 73724 14344 109136 14343 68165 14149 14148 12894 18181 67544 75778 230753 69923 13081 19063 257633 433256 13072 83603 15492 74522 15497 54397 13079 50790 15487 328845 74205 57874 14979 30963 104112 106529 54325 66775 12683 94180 12686 216739 74559 234309 243078 70757 56348 104709 99035 26568 54326 77582 67512 14712 108079 18779 239759 26971 333433 19341 108097 108958 99010 210992 14555 26970 26565 20444 215708 102247 18784 18782 78390 66350 231510 52123 114874 28169 68262 66659 18806 55979 225010 18778 14792 329502 320207 66857 271844 67452 237625 665270 270084 53357 67216 68255 232889 18710 225845 11886 70625 68975 244209 234959 94112 13001 13000 70208 100039026 103236 11520 56771 50493 228775 80509 108099 30955 18708 18709 18706 108083 74769 18707 98386 14776 56310 26896 28250 11409 93747 15107 64291 20216 56473 76267 19156 271457 14466 64436 19211 18805 20698 56491 67279 23945 75497 16890 18718 20494 19045 20493 64899 16866 106407 21884 330962 14626 26459 14933 170460 67469 215456 71519 14245 106648 19046 100040843 234729 103968 13078 11370 54384 66905 17772 64898 320981 13350 216724 12140 210376 16204 66569 16592 11864 241274 99138 14077 17979 240752 233549 18705 67800 234129 14571 50767 68393 18720 14079 68616 14080 18719 75772 97287 11770 233315 11842 106869 107650 103199 244882 100043508 18711 12169 233552 268783 69769 74302 53332 219135 84095 319934 240753 101490 231999 109135 19062 269180 66443 234515 83435 83436 101476 56209 170749 59024 327987 225742 26938 16211 20182 19025 57357 97212 50877 11363 231086 12038 12647 11423 19384 20454 54486 14865 11606 11686 23801 13116 625249 13115 14104 110115 18010 394434 56050 23956 219024 19215 69790 99712 17113 236899 12651 237928 11840 56018 212862 12660 13026 76574 106861 18559 18618 66427 20598 67041 58994 64059 69772 208982 110446 15360 78894 71911 15356 170826 75669 26457 225326 74159 58911 271970 67902 75613 22260 545260 20181 22337 19013 11883 19883 18783 59004 74008 77041 26379 19016 22196 100043429 20787 216820 19141 264064 19731 14473 94224 13074 78925 20597 18739 18704 74596 19679 327958 52858 74121 11364 11863 67460 13177 216154 18717 51813 69792 26922 20975 20466 14725 18976 67381 19015 SIGNALING BY RAS GTPASE MUTANTS%REACTOME%R-HSA-9753512.2 Signaling by RAS GTPase mutants 15461 16653 18176 SLC-MEDIATED TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-9955298.2 SLC-mediated transport of organic anions 100434 213603 11998 227394 242259 75750 70129 68682 63993 101488 114644 216225 27376 235504 18399 13358 19879 20521 20502 28250 57274 58807 80879 20501 20503 13723 12215 20500 28253 24059 241612 108115 237831 67863 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME DATABASE ID RELEASE 96%5579028 Defective CYP17A1 causes AH5 13074 MTB IRON ASSIMILATION BY CHELATION%REACTOME DATABASE ID RELEASE 96%1222449 Mtb iron assimilation by chelation 17002 DEFECTIVE DPM3 CAUSES CDG-1O%REACTOME%R-HSA-4719360.4 Defective DPM3 causes CDG-1o 13481 68563 13480 FORMATION OF WDR5-CONTAINING HISTONE-MODIFYING COMPLEXES%REACTOME%R-HSA-9772755.2 Formation of WDR5-containing histone-modifying complexes 15161 228829 108155 231051 67278 74322 17283 217031 226976 101739 208146 76719 66310 75812 140858 69556 69612 233904 101206 208043 13486 213464 217588 54194 108946 67933 214162 665775 75565 228714 56406 67773 239510 77305 14534 75410 22289 55982 18519 23808 381022 PURINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%74259 Purine catabolism 230718 214254 50773 18950 14544 53893 66358 75686 76952 23959 381101 22436 16434 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME%R-HSA-210746.3 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells 53626 11925 18088 18012 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME DATABASE ID RELEASE 96%168176 Toll Like Receptor 5 (TLR5) Cascade 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 71481 667035 26416 211550 22190 17258 20203 26410 26409 20210 24110 26413 103583 257632 26417 26940 266632 26401 80750 223664 53791 107607 19094 69721 102626 231130 93834 270151 73699 11596 26395 67454 22059 240518 71966 110651 108960 20112 59025 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 12370 21770 22030 67245 26399 26400 18034 26398 26420 13712 26414 26397 17260 434174 66513 93765 66589 23939 22034 66724 68652 20111 11909 26419 12675 16476 18033 18035 18036 11820 DEFECTIVE ALG1 CAUSES CDG-1K%REACTOME%R-HSA-4549380.4 Defective ALG1 causes CDG-1k 208211 MATURATION OF TCA ENZYMES AND REGULATION OF TCA CYCLE%REACTOME%R-HSA-9854311.2 Maturation of TCA enzymes and regulation of TCA cycle 68002 11429 269951 66945 110446 14297 66072 71238 68332 66052 67680 380840 64384 66925 74316 12974 DENGUE VIRUS GENOME TRANSLATION AND REPLICATION%REACTOME DATABASE ID RELEASE 96%9918487 Dengue Virus Genome Translation and Replication 67443 12282 13200 233726 13682 12317 13681 269523 235623 193740 667035 12330 22190 16211 100039592 16648 100037258 171210 13480 22196 217365 13481 20168 381686 16649 22352 18107 81910 230861 66892 213539 22230 66357 24127 68563 66624 14104 56445 11806 16646 66286 14827 18453 56298 103573 223697 18452 20014 66861 103963 218490 69038 13135 76687 69019 15481 18451 13684 22608 208643 56529 67075 110611 13690 14828 320452 67838 80286 192170 68292 19092 16430 18458 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.4 Metalloprotease DUBs 12021 328572 216799 319176 320713 20844 12189 667035 22190 59029 68251 20184 70527 70681 76630 109359 107976 210766 319169 18519 621893 319162 15267 319173 319163 319168 319167 MITF-M-REGULATED MELANOCYTE DEVELOPMENT%REACTOME%R-HSA-9730414.5 MITF-M-regulated melanocyte development 233833 21943 17342 20665 21415 20682 18992 12387 15901 12575 209446 12550 17202 67155 107508 22628 20586 17201 21425 20588 16842 20587 17295 12443 12566 11652 12047 21385 69675 19303 12558 13612 26416 16881 11886 21417 232313 21752 329581 26413 18787 26417 21418 54401 328572 21414 21416 17216 239985 17218 13367 19017 56456 103573 66993 11972 93759 108664 66290 12578 12914 11964 93760 11966 100039636 66335 11973 11974 114143 12043 13190 22627 22173 22178 12531 20674 192119 245049 70127 16364 29861 269397 20431 19708 268996 16398 11891 171531 12055 12054 11461 77836 77045 83671 17364 18241 22196 68094 83796 83797 57376 76850 239528 236511 17918 22416 12189 213988 217351 56637 214150 21426 20583 20111 107045 226414 17454 97541 17169 216443 18505 22278 22631 13616 66355 22629 105148 15254 20466 231872 13614 66143 22771 18976 18817 17199 433759 13618 16590 15221 12977 104458 11694 68292 21386 23797 85305 17203 13722 COENZYME A BIOSYNTHESIS%REACTOME%R-HSA-196783.7 Coenzyme A biosynthesis 66812 74450 71743 75735 68087 211347 106564 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME%R-HSA-195253.4 Degradation of beta-catenin by the destruction complex 12234 93687 56436 17463 57296 21415 20422 26445 12387 26446 360216 19172 19173 19175 72345 19177 21402 56438 16842 26443 26444 19170 66413 26965 667035 22190 12005 59029 67089 70247 21885 21886 14296 73699 21888 212398 19052 19053 51792 226849 225849 26931 21770 26932 21414 21416 56637 21887 14797 21762 22123 19179 19181 19182 23996 19184 26440 433759 13017 19166 13016 19167 26441 26442 11789 69077 66997 23997 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 96%8934903 Receptor Mediated Mitophagy 66734 22241 13001 72018 13000 100039026 67443 67526 11793 G ALPHA (Z) SIGNALLING EVENTS%REACTOME%R-HSA-418597.6 G alpha (z) signalling events 14702 14696 56470 104110 14697 14678 14677 240816 14687 18751 14679 18754 14710 432530 18755 14699 210044 66066 18761 104111 19734 14700 14688 14708 14706 14704 14695 224129 18753 11512 14693 11513 58175 11514 64337 11515 14709 18752 14701 11551 11552 11553 18750 56533 19736 242851 DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME DATABASE ID RELEASE 96%4793950 Defective MAN1B1 causes MRT15 227619 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139910 Activation of BMF and translocation to mitochondria 68097 26419 171543 SIGNALING BY HIPPO%REACTOME%R-HSA-2028269.3 Signaling by Hippo 22601 16798 54401 68473 75723 50523 232157 260305 21873 211652 56332 64010 56274 21872 13543 58231 12367 97064 22627 NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.4 Negative regulation of MET activity 19255 58194 20408 12402 56324 84092 15239 16206 20404 17295 15234 20844 20405 13858 667035 19246 22190 19271 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655332 Signaling by FGFR3 in disease 327826 14172 80857 14184 14180 64654 14175 18176 14388 20662 14173 14164 15461 18803 80903 18708 18706 SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 96%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 100043429 56459 50995 20610 22196 CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.5 Citric acid cycle (TCA cycle) 100042811 18293 78920 14194 56451 68015 20916 20917 14297 71238 68332 13382 380840 18115 15929 68002 170718 11429 67834 269951 66945 110446 66072 66052 67680 64384 66925 74316 12974 17448 SIGNALING BY LTK%REACTOME%R-HSA-9842663.1 Signaling by LTK 74769 16367 17005 51789 14784 18708 18709 18706 20662 620393 ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.3 Alpha-defensins 22072 12504 11870 SLC15A4:TASL-DEPENDENT IRF5 ACTIVATION%REACTOME%R-HSA-9860276.3 SLC15A4:TASL-dependent IRF5 activation 71398 16151 27056 100561 12675 16150 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.5 Signaling by Erythropoietin 74769 18707 13857 234779 320207 17096 18176 14388 20662 20851 22324 20850 15461 13856 107746 12929 18803 30955 18708 384783 16452 18706 20416 CIRCADIAN CLOCK%REACTOME DATABASE ID RELEASE 96%9909396 Circadian clock 20893 21425 66277 272322 12457 79362 18787 214162 13001 13000 100039026 19047 19014 229003 11865 19377 328572 21372 104318 109151 17977 19017 18143 17978 59035 81004 66993 17260 17261 12753 268903 19885 70461 15183 18626 20185 18627 225998 93759 18628 217166 12953 74343 12952 12914 382056 56406 11909 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 12568 26442 69077 66997 23997 27373 12234 56436 17463 57296 20422 26445 11998 26446 19172 19173 19175 14068 19177 21402 56438 26443 26444 19170 19653 66413 13170 26965 217732 667035 17691 22190 59029 67089 103583 70247 20181 19013 19883 50789 20787 12894 59027 19045 19046 216080 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.3 TRAF6 mediated NF-kB activation 26401 22030 69721 11596 71586 19697 230073 71966 12675 71956 16150 18034 228607 217069 16151 18033 434174 18035 18036 20203 11820 20210 22034 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME DATABASE ID RELEASE 96%400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 18508 66624 233081 66286 56529 18548 14607 14463 16392 236781 76687 13482 69019 DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME DATABASE ID RELEASE 96%5619055 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) 238384 GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.8 Glycogen breakdown (glycogenolysis) 640703 56043 77559 72157 68961 18679 110094 102093 110078 27357 18682 110095 14387 19309 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.11 Metabolism of Angiotensinogen to Angiotensins 104158 11606 13809 17228 64138 14943 56373 70008 17380 16790 76703 12873 70495 11421 100038824 13035 13033 REGULATION OF NPAS4 MRNA TRANSLATION%REACTOME%R-HSA-9768778.2 Regulation of NPAS4 mRNA translation 233833 213988 236511 217351 17454 214150 225872 76850 239528 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME DATABASE ID RELEASE 96%442755 Activation of NMDA receptors and postsynaptic events 12326 14811 18039 216963 14810 11472 20779 320472 19087 19084 23859 14814 68606 52163 14813 12322 12323 108058 12325 26413 26417 18747 100039592 13385 53310 13383 110651 18176 20112 15461 108099 18607 53623 14799 241113 19088 16559 14802 55984 19108 19417 19418 19353 211323 22343 432530 14800 20111 640703 105787 11514 108079 14812 108030 64011 19079 18749 207565 108097 12361 19082 319924 67071 170483 22342 19085 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME%R-HSA-8941326.2 RUNX2 regulates bone development 12842 12400 56275 225207 19645 20779 22612 15185 97064 68527 15183 26413 26417 11350 15213 16147 15214 11835 22601 212712 17125 14634 208727 15205 17128 14633 17130 17132 170574 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME%R-HSA-8964539.5 Glutamate and glutamine metabolism 108653 14660 18242 66194 69051 209027 70266 14719 14661 14645 194237 216456 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 96%70171 Glycolysis 18639 18640 170768 18648 56012 15277 70974 15275 56421 18663 67980 18747 14447 19386 231103 73699 216019 14751 19052 19053 51792 170762 108989 231042 227699 100043349 223921 227720 445007 269113 11674 66679 72141 18141 230163 107939 212032 69482 21770 71805 226265 54563 19069 70699 72787 13806 18226 218210 21991 69912 13808 18655 103988 13807 103468 234865 59015 18749 69736 110379 270198 18641 11676 18642 26384 12183 RESPIRATORY SYNCYTIAL VIRUS (RSV) GENOME REPLICATION, TRANSCRIPTION AND TRANSLATION%REACTOME%R-HSA-9820965.1 Respiratory syncytial virus (RSV) genome replication, transcription and translation 13001 16211 13000 100039026 66624 19047 66286 56529 19045 103573 18550 19046 76687 69019 15516 15481 15519 REGULATION OF MITF-M DEPENDENT GENES INVOLVED IN METABOLISM%REACTOME%R-HSA-9854907.3 Regulation of MITF-M dependent genes involved in metabolism 19017 93759 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 96%418890 Role of second messengers in netrin-1 signaling 22063 18738 22065 22067 18803 22066 26946 22068 13176 18208 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 96%450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 72544 50911 24127 69639 72662 66446 227715 70640 75901 54401 17164 238799 22695 66362 109075 66583 27998 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME DATABASE ID RELEASE 96%983231 Factors involved in megakaryocyte development and platelet production 74947 16570 319149 19087 19084 12566 15077 73470 12419 16563 16568 18747 11350 11640 217837 73804 16362 76088 16452 15129 16594 14462 229841 668303 22762 16579 232943 14461 17135 14460 19348 17134 14463 71819 16593 16551 22365 110033 209737 74764 15977 208869 78287 271457 210293 17863 12568 63955 22390 228421 26934 75974 16923 23921 240641 269152 16565 319899 16564 16552 16580 16581 13660 68813 16561 68732 16562 108829 20399 16558 56697 70218 15135 252966 75050 17133 16554 15132 286942 56248 259300 16578 57440 319991 16572 171580 16573 14464 16560 22059 94176 330662 238130 18022 19363 16363 114714 19088 14465 19353 99982 217864 12343 12345 15353 16569 12340 16571 20466 18749 625328 433759 67414 22761 170731 15182 67299 19085 TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.4 Transcriptional activation of mitochondrial biogenesis 216151 15161 12326 381760 20181 19013 26379 18181 14390 19014 68346 229003 11655 14661 226169 670717 15278 21780 21372 109151 17977 19017 60525 17978 59035 81004 66993 17260 17261 224481 208595 70461 15183 20185 217166 74343 12914 382056 56406 11909 640703 11947 75387 269951 20656 170826 64384 226153 50776 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.2 Biosynthesis of EPA-derived SPMs 16993 15446 11687 19225 11689 DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 96%5579019 Defective FMO3 causes TMAU 14262 KERATINIZATION%REACTOME%R-HSA-6805567.5 Keratinization 626834 227937 20765 70166 13706 66203 317653 71529 69511 21816 20129 668304 66344 13507 13506 16480 13505 386463 99681 14027 12365 76770 19143 72432 67451 259277 16769 74176 19041 68668 76560 16939 20754 240633 56460 18550 18553 16678 12336 12333 13511 13510 18772 109620 13512 64058 117172 56735 77055 75706 26560 435286 320864 94179 406221 69533 629873 69473 109052 70810 223917 100039486 68673 670464 435285 66708 100041488 223915 406220 16681 16675 16663 16661 268482 16682 110308 16687 110310 16691 107656 100040248 16664 239932 16665 16666 16660 16670 16694 77914 66809 71369 435273 16667 16668 105866 16680 53622 16679 406222 71888 16671 16672 53617 114566 406219 100040249 546511 76444 268905 332131 170654 74127 237934 100039757 CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.3 Cargo concentration in the ER 56389 193813 56494 14799 235416 66397 66890 69608 217615 218811 99683 338366 20703 70361 14067 77371 14275 12793 20334 100042773 20333 64138 21802 13032 12794 214895 14069 11839 333883 72978 12836 100042343 50907 MITOCHONDRIAL TRANSLATION%REACTOME%R-HSA-5368287.5 Mitochondrial translation 64658 66419 64660 78523 94061 623346 102060 50529 233870 100040519 68565 99045 66973 69163 52443 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 70316 67681 66399 108853 64655 211253 107733 320806 68537 17721 18100 17722 67707 17716 94066 17717 60441 17718 218506 17719 66230 17720 68463 67871 65111 74600 107734 66242 28028 68735 622268 27398 94067 28030 67840 68836 79044 94065 57312 75398 68572 67308 64659 56282 66292 24030 66121 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 17711 17708 17709 17710 239555 69606 76784 17705 76366 67851 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 96%202670 ERKs are inactivated 21770 73699 101568 235584 67603 19052 319520 72349 19053 51792 23939 26413 26417 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020933 Interleukin-23 signaling 20848 16160 54721 20849 209590 16452 18453 16161 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.2 Defective Inhibition of DNA Recombination at Telomere 22589 13163 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 96%1810476 RIP-mediated NFkB activation via ZBP1 56532 69721 58203 19697 106759 71966 12675 16150 18034 16151 17874 18033 18035 13211 18036 142980 19766 HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 96%3371497 HSP90 chaperone cycle for SHRs 56444 56445 67665 56455 22428 13191 12344 59288 20867 69654 14229 193740 14228 15481 15519 234663 12343 81489 12345 235661 11835 12340 14815 100043508 68097 54130 110784 53598 58233 13427 18667 15502 13426 13424 15516 15512 15482 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.3 APC C-mediated degradation of cell cycle proteins 12234 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19645 19177 21402 26443 26444 12566 19170 66413 26965 56371 667035 27401 22190 59029 67089 70247 30939 18005 20877 12428 229776 12237 67141 107995 12427 56150 21762 22123 20878 19179 19181 19182 217232 23996 56317 12236 19184 59008 18817 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 FASTK FAMILY PROTEINS REGULATE PROCESSING AND STABILITY OF MITOCHONDRIAL RNAS%REACTOME DATABASE ID RELEASE 96%9837092 FASTK family proteins regulate processing and stability of mitochondrial RNAs 75619 21379 380601 NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 96%927802 Nonsense-Mediated Decay (NMD) 622534 238217 14852 16785 666669 100040021 67025 100043391 326622 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 67031 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 19052 100042740 19951 51792 667618 100040970 267019 56040 67248 100040331 67941 57294 68092 433702 192160 208643 60365 68134 192170 19826 66441 17149 667035 75901 19704 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 233789 71978 65019 103677 629957 226517 20102 74133 229512 20103 71997 668668 667739 14853 672214 66481 225058 100038875 100038991 68028 225363 100043000 67891 100043295 18458 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME%R-HSA-8964616.2 G beta:gamma signalling through CDC42 14708 14706 14702 14704 14696 14695 73341 14693 64337 14709 14697 14701 14710 14699 66066 14700 18479 14688 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669936 Sorafenib-resistant KIT mutants 16590 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.7 SUMOylation of transcription cofactors 328572 26885 109113 19763 223701 100040573 20602 54383 67040 13619 17977 19017 241915 12416 17978 17190 224903 18148 19821 13163 268903 15258 12914 13207 106021 56469 21849 59004 30951 20610 22196 12418 20466 100043429 57320 229615 13016 12151 69260 22658 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME DATABASE ID RELEASE 96%5619050 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) 20533 DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME DATABASE ID RELEASE 96%1474228 Degradation of the extracellular matrix 20750 12550 24087 21892 12153 16621 12505 13038 17395 268958 13039 12339 17392 15530 23830 17394 17384 56213 17388 23948 58223 17229 72947 50817 83995 269120 72902 18550 170725 64706 11502 240047 11501 17391 381122 73647 268935 12335 12215 12338 30800 12337 12334 23993 12336 17385 17381 71753 69543 12380 12333 17228 11487 11491 12367 18073 12817 12816 22072 12821 107581 77018 12819 16776 16777 16780 12822 19164 226519 12841 16782 12823 11490 12840 59287 16774 12818 140709 13040 237759 12839 13030 17386 50701 232345 23794 13033 30806 271127 208936 66473 17390 21858 21857 11504 18815 17387 17389 17393 13035 240913 12032 13179 DISEASES OF NUCLEOTIDE METABOLISM%REACTOME%R-HSA-9735804.2 Diseases of nucleotide metabolism 18950 15452 11486 11821 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.4 G protein gated Potassium channels 242425 14702 14696 16519 16520 54393 14697 16518 16516 14710 14699 66066 14700 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 14693 16517 64337 14709 14701 TRANSPORT AND METABOLISM OF PAPS%REACTOME%R-HSA-174362.8 Transport and metabolism of PAPS 108652 23971 23972 268512 13521 73836 231583 SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME%R-HSA-2142670.3 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 13110 13850 13078 72303 107141 13077 13076 CYP2E1 REACTIONS%REACTOME%R-HSA-211999.4 CYP2E1 reactions 74134 13087 13107 13106 72303 107141 13088 56448 EPHB-MEDIATED FORWARD SIGNALING%REACTOME%R-HSA-3928662.4 EPHB-mediated forward signaling 110596 11848 14810 22612 76709 19353 73178 16885 16886 56443 11461 14360 68089 67771 12631 15529 11867 56378 66713 74117 545156 16443 17096 14812 19877 218397 21844 14083 15461 11465 19878 18479 TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.3 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 56438 667035 13871 16881 22190 66420 67439 69833 67710 245841 69920 20022 14885 66983 209357 71101 66467 71991 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 23894 14884 11834 12848 27015 69745 100043806 26891 59001 319955 22594 26754 16882 19687 19718 69263 66979 56031 26893 21399 18538 26894 28000 13870 68275 108679 106344 72151 18971 68240 18972 252870 22590 19891 18973 26572 18974 22592 50505 26895 67967 57905 13716 99375 72584 13194 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.4 Retinoid metabolism and transport 68453 65107 67442 15530 67861 11806 238055 11816 16956 665270 103978 63857 17252 55938 105349 14733 22139 11807 239393 11808 15529 11603 23888 20971 79235 20969 16835 14734 170752 11813 11814 69060 77337 109791 83702 19662 14725 71951 20970 19660 16971 14735 19659 TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME DATABASE ID RELEASE 96%975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 71481 667035 26416 211550 22190 17258 20203 26410 26409 20210 24110 26413 103583 257632 26417 26940 266632 26401 80750 223664 107607 19094 69721 102626 231130 93834 270151 73699 11596 22059 26395 67454 240518 71966 110651 108960 20112 59025 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 170743 14281 12370 17087 21770 22030 12475 67245 26399 225471 106759 26400 18034 26398 26420 13712 26414 26397 17260 434174 21898 66513 93765 23939 66589 22034 66724 68652 20111 11909 26419 12675 16476 18033 18035 18036 11820 81897 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.2 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations 22589 13163 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.4 Response to elevated platelet cytosolic Ca2+ 11472 12331 18643 18787 239273 16002 16000 12491 12527 22371 16416 16784 14161 21894 21825 56744 110135 99571 22330 109711 54216 11806 667310 640703 385643 268373 19156 15234 18752 22041 14828 19128 13645 11820 14456 72017 57349 18751 22145 16399 14268 11818 27359 12258 21346 20716 268936 192176 18591 117586 11674 109232 71946 12759 215789 235505 67988 12321 11537 18613 26968 68038 20912 20911 21922 20255 108101 218454 223601 12512 80718 16426 22138 227612 232345 60595 104009 320202 70945 53612 67059 11657 20703 11625 20909 21767 19073 56541 74145 14067 12631 14205 80884 20344 68117 21859 74840 94175 13041 20363 11747 21857 16427 18815 56193 18816 21803 19039 21808 56055 13601 240334 14069 20692 22388 75396 22341 22339 18407 22340 11804 18750 71660 67072 21809 66866 27999 DEVELOPMENTAL LINEAGES OF THE MAMMARY GLAND%REACTOME%R-HSA-9924644.2 Developmental Lineages of the Mammary Gland 11839 21802 13645 14165 19109 ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 96%9010642 ROBO receptors bind AKAP5 18747 19056 268902 18750 19087 238276 18749 TLR3 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602410 TLR3 deficiency - HSE 142980 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 96%9614657 FOXO-mediated transcription of cell death genes 328572 14103 12914 17684 54601 18044 18045 56458 18046 13198 56484 20869 12053 12125 68943 INORGANIC ANION EXCHANGE BY SLC26 TRANSPORTERS%REACTOME%R-HSA-427601.5 Inorganic anion exchange by SLC26 transporters 208890 320718 23985 13487 268512 13521 231583 171429 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 96%5669034 TNFs bind their physiological receptors 21943 14103 171211 85030 50930 21940 21941 21949 21948 21936 16992 230979 13608 13607 21942 21937 21938 18383 21935 240873 69583 24099 57916 22163 22164 245527 326623 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME DATABASE ID RELEASE 96%168164 Toll Like Receptor 3 (TLR3) Cascade 66105 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 21770 26399 26400 26398 26420 13712 26414 26397 17260 23939 11909 26419 12675 16476 18033 18035 18036 11820 12234 56480 54131 19697 21402 73086 16150 16151 192656 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 80750 223664 107607 69721 231130 270151 11596 22059 67454 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 142980 19766 11797 56532 22030 22031 56489 11796 106759 21353 18034 71648 54123 434174 100041766 14082 66513 93765 66589 22034 66724 68652 20111 216080 SPOP-MEDIATED PROTEASOMAL DEGRADATION OF PD-L1(CD274)%REACTOME DATABASE ID RELEASE 96%9929491 SPOP-mediated proteasomal degradation of PD-L1(CD274) 56436 17463 57296 20422 26445 26446 19172 19173 22628 19175 19177 56438 12567 26443 12443 26444 19170 66413 667035 22190 59029 67089 70247 13001 26554 13000 100039026 20747 21762 22123 19179 19181 19182 23996 19184 26440 60533 19166 19167 26441 26442 69077 66997 23997 SIGNALING BY MAPK MUTANTS%REACTOME%R-HSA-9652817.2 Signaling by MAPK mutants 75590 235584 18218 67603 63953 70686 26413 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME DATABASE ID RELEASE 96%9706374 FLT3 signaling through SRC family kinases 20963 14256 15162 16818 14255 14360 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME%R-HSA-5619040.4 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) 20505 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME%R-HSA-1299344.3 TWIK-related spinal cord K+ channel (TRESK) 332396 ADENOSINE P1 RECEPTORS%REACTOME%R-HSA-417973.3 Adenosine P1 receptors 11539 11541 11540 11542 MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%8851907 MET activates PI3K AKT signaling 18708 14388 15234 18706 17295 NUCLEOTIDE CATABOLISM%REACTOME%R-HSA-8956319.4 Nucleotide catabolism 230718 268782 50773 103850 22271 67464 12495 12499 12496 12497 215446 14544 53893 72090 66358 75686 76952 381101 93685 16434 22436 214254 18950 56045 23959 64705 76654 72962 99586 103149 NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%392154 Nitric oxide stimulates guanylate cyclase 58802 242202 18125 18127 23984 241489 18585 17540 18574 54195 18573 72413 60596 207728 16531 16533 234889 18126 19092 435726 16438 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN EXTRACELLULAR MATRIX, FOCAL ADHESION AND EPITHELIAL-TO-MESENCHYMAL TRANSITION%REACTOME%R-HSA-9926550.1 Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition 69675 19303 16398 12558 13612 12550 21417 232313 20674 68292 18787 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701192 Defective homologous recombination repair (HRR) due to BRCA1 loss of function 12021 81601 327762 20422 233826 19361 114714 22427 19362 11920 12189 12190 237911 57434 19360 225182 26909 17535 21975 19363 19364 12144 27354 MODULATION OF HOST RESPONSES BY IFN-STIMULATED GENES%REACTOME%R-HSA-9909505.2 Modulation of host responses by IFN-stimulated genes 23806 52668 56791 74153 13666 71586 230073 100038882 12675 16150 15061 217069 16151 14229 14828 226641 DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME DATABASE ID RELEASE 96%5658208 Defective SLC5A2 causes renal glucosuria (GLYS1) 246787 DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610783 Degradation of GLI2 by the proteasome 12234 93687 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 56637 667035 22190 59029 67089 70247 18747 21762 22123 14633 19179 18749 19181 19182 23996 19184 26440 19166 24069 19167 26441 26442 69077 66997 23997 DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME%R-HSA-5654716.3 Downstream signaling of activated FGFR4 327826 14172 80857 14170 14180 14177 64654 14175 18176 14388 20662 14173 14164 15461 83379 107971 18803 80903 18708 19247 14186 18706 CELL DIVISION%REACTOME%R-HSA-68884.6 cell division 71175 74549 100710 218914 20842 19348 18817 71819 71521 24061 20843 19357 13006 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.4 2-LTR circle formation 23825 319583 22596 14375 15361 101739 108138 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME DATABASE ID RELEASE 96%5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) 107723 DEFECTIVE GALT CAN CAUSE GALCT%REACTOME%R-HSA-5609978.5 Defective GALT can cause GALCT 14430 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.4 RNA Polymerase II Transcription Elongation 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 20924 23894 14884 68092 433702 20922 20833 67655 21399 107951 57314 114741 76246 214498 12454 66317 58202 235497 67923 22083 27224 27632 24116 12455 72949 54624 13716 64144 20926 93736 70122 74427 73473 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-HSA-983695.6 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 269717 18707 12143 17973 58194 234779 109305 12483 22324 20963 22063 12229 17060 20866 12518 15985 229709 14360 16438 16439 640703 15170 16440 17096 20662 26377 12478 18708 83490 MEIOSIS%REACTOME%R-HSA-1500620.4 Meiosis 17350 232440 319149 12567 12566 15077 13404 26972 19183 217716 76915 55993 17687 94244 20842 22196 213389 28113 15267 101185 319168 319167 19360 24061 17535 21975 19357 319186 15512 27354 319178 319183 60530 319182 319190 19361 114714 57321 319176 223697 319181 11920 12189 12190 319152 21749 497652 225182 21750 12144 13006 381306 68275 68240 19891 319169 625328 56739 78303 140557 319188 50878 15270 20962 74075 16906 320558 64009 319565 71846 624153 66654 20957 75459 20843 77053 382522 PROTEIN HYDROXYLATION%REACTOME%R-HSA-9629569.1 Protein hydroxylation 269955 77035 67014 65973 66521 71952 270086 13495 107817 667739 69082 14071 100038875 225363 665189 13494 194952 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME%R-HSA-6803544.3 Ion influx efflux at host-pathogen interface 18173 11977 11927 72621 PKA ACTIVATION%REACTOME%R-HSA-163615.6 PKA activation 18747 640703 224129 19088 11512 11513 11514 19087 19084 11515 18749 104110 432530 210044 104111 19085 DEFECTIVE CYP21A2 CAUSES AH3%REACTOME DATABASE ID RELEASE 96%5579021 Defective CYP21A2 causes AH3 13079 PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME DATABASE ID RELEASE 96%8849468 PTK6 Regulates Proteins Involved in RNA Processing 20459 20218 13992 170771 71514 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-HSA-8981607.3 Intracellular oxygen transport 17189 114886 64242 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%169911 Regulation of Apoptosis 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 78514 74143 67089 70247 67013 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 224105 26441 26442 69077 66997 23997 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME%R-HSA-1299361.3 TWIK-related alkaline pH activated K+ channel (TALK) 74571 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 96%5683371 Defective ABCB6 causes MCOPCB7 74104 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.5 Translation of Structural Proteins 93687 71164 53618 20448 227619 19089 13200 208884 667035 12330 22190 22196 66357 20014 103963 56637 69038 13135 15469 103534 67075 57377 27801 228136 75965 70546 20817 14423 108687 20815 214424 269181 328417 57437 606496 217664 67287 69035 80285 107895 52552 20446 671535 20444 547253 20442 80286 20443 17308 17158 68292 20440 67569 16430 14376 20447 VIRAL MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 96%192823 Viral mRNA Translation 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100037258 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 27207 67097 670832 231413 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 96%2173782 Binding and Uptake of Ligands by Scavenger Receptors 12843 15129 12842 15122 12282 71693 11806 12317 238055 11699 15458 11816 15439 192188 16069 93671 434174 11657 20210 20202 192187 15519 14325 12491 20288 117158 140792 71145 12827 17167 12826 12825 380713 11801 269855 14319 15505 16971 20692 18477 22027 DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME DATABASE ID RELEASE 96%5687613 Diseases associated with surfactant metabolism 27410 12984 12982 20387 20390 20389 20388 20531 NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5654726.4 Negative regulation of FGFR1 signaling 327826 80857 14180 12402 14177 67112 24064 64654 17346 14175 14174 14173 14164 19052 109880 19053 51792 667035 22190 19247 26413 26417 14165 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.5 SCF(Skp2)-mediated degradation of p27 p21 54124 56436 20459 17463 57296 20422 26445 12428 26446 12575 19172 19173 19175 19177 21402 12567 26443 12443 26444 12566 19170 12447 66413 26965 667035 27401 22190 12448 59029 12576 67089 70247 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 GPCR DOWNSTREAM SIGNALLING%REACTOME%R-HSA-388396.8 GPCR downstream signalling 17202 17201 20779 22094 12640 18754 18755 320127 26413 76192 26417 104418 56077 66082 22325 231871 380921 110524 269060 110197 217480 13139 331374 140498 212108 57257 19773 242093 18176 381489 20662 19877 239336 16336 15461 23919 52666 16800 13605 109689 19878 216869 213498 207212 71704 234094 56349 16801 11852 75547 72754 69632 213649 24001 224014 230098 53972 30938 21390 77669 442801 226970 235611 54126 101497 14673 269608 640703 328967 14163 19055 26382 19056 268739 19419 14674 73341 11550 11853 19058 11548 11549 12568 11820 109934 11554 11555 11556 15560 15559 15558 213788 15557 13492 382348 13491 381853 13490 14607 13488 14697 111174 215855 503558 54598 215854 12672 12671 19226 15552 14710 15466 14699 15551 66066 14700 243764 12669 93896 15465 18241 14708 209512 14706 15566 15565 12310 15563 14704 15562 11516 225192 14695 14652 11517 12311 14693 64337 14709 15874 12921 12918 14701 114640 223780 54409 19227 19228 56089 213527 51801 14602 14601 11535 14702 14696 14527 14526 19088 19108 12267 104110 22354 14678 14677 12229 22353 14687 20287 14679 432530 210044 22355 104111 19057 14688 70086 224129 11512 11513 11514 11515 18749 11541 242851 19085 58861 12322 12323 108058 12325 229709 16438 16439 18798 18747 16440 73699 110651 20112 19052 19053 51792 21770 14680 55984 19418 54393 23939 21844 207565 18752 236915 242425 18429 11998 18430 54140 26361 12000 14685 212541 20210 15139 12266 104709 207911 18750 23797 18796 18797 14686 18795 12326 320207 19084 11651 11652 22324 18710 13649 14419 12772 12774 12768 30955 80901 18708 18709 84112 18479 20607 387512 18706 12776 18607 12775 12458 12773 12771 170458 18386 18389 14539 19214 243270 239283 387513 19222 14427 19217 18166 19218 19219 18167 18168 14294 12802 14293 12801 14309 387353 387515 353148 12765 227288 14308 56838 57811 17773 244701 353165 387348 387356 19156 20605 19065 20606 19064 80885 12145 20609 20608 14428 13051 227289 217212 208990 110326 83770 20132 140795 57349 30878 17329 20290 11848 17200 102098 18155 55985 20303 109648 20304 12057 14675 20296 24012 57385 19739 20297 100039973 74191 50782 100038965 277360 13610 56066 20311 50779 20312 20300 11539 11540 18610 18619 11542 66102 13611 14672 622434 22095 330122 51791 14823 12922 14608 16412 108073 67839 545156 268934 23984 16443 94226 241489 14676 108069 19049 108068 67792 20310 58175 14825 18545 353344 218461 14429 18577 17207 14764 110385 13603 238871 11609 207728 23796 54611 14682 83771 18584 574417 67865 387347 71729 57253 18583 12777 80910 57254 381413 109904 387355 93690 387342 238725 230972 387349 626596 71223 12766 239530 226304 383563 387616 76123 321019 29863 12778 14761 381073 26385 110168 106512 223435 436440 76854 12769 15199 23945 14763 70839 19045 171469 16866 16867 227326 14739 12854 16952 15945 20315 12767 19087 20663 14459 53978 22044 22045 624910 57260 233571 235036 246709 13617 19734 30044 14715 14714 13615 18441 246691 18442 100039592 14745 16963 16995 208188 229214 56183 56696 210198 58182 19204 104443 224065 19216 19220 64214 319239 14816 14289 12374 108071 238377 14744 225642 50778 56744 19735 50780 19736 14829 67168 21333 11606 11607 12061 12062 17392 56470 216749 21338 19737 14064 65086 14063 14062 14061 21337 15200 23832 319197 21334 21336 240816 12424 12425 12426 217369 227717 14065 381810 107221 280287 24111 574402 78134 100043254 237362 385643 433292 246313 233079 233080 233081 50501 67405 18216 14773 54615 12209 78826 114229 15171 110312 18217 387285 230777 11551 14767 11552 68039 11553 18101 56533 18576 22065 18387 18390 18751 22068 26946 18753 18783 110355 18575 18574 18573 16402 12273 20604 18761 19395 20111 320129 13616 13614 18976 17199 13618 17203 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME%R-HSA-446210.4 Synthesis of UDP-N-acetyl-glucosamine 19703 245847 54342 109785 56174 14583 107652 14584 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME%R-HSA-5656169.2 Termination of translesion DNA synthesis 56791 59001 74153 19687 100038882 19718 69263 22224 66979 26447 56210 68026 216835 667035 22190 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 80905 67967 217069 27015 69745 PTEN REGULATION%REACTOME%R-HSA-6807070.4 PTEN Regulation 233833 13626 18854 66894 72607 68031 73162 11651 19720 11652 21951 74493 14302 52615 17999 19646 234366 26413 26417 21907 13001 13000 100039026 56233 245688 12418 23942 17192 14013 12151 19763 54383 13619 241915 12416 19821 15183 66508 545987 54170 11909 52187 494448 68576 66096 83409 74370 68441 21762 30951 22123 268706 19179 19181 245670 19182 23996 19184 16476 99377 26440 19166 19167 26441 26442 69077 66997 23997 216848 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 107932 26443 26444 19170 66413 667035 19211 22190 59029 67089 70247 19712 22059 19016 13498 68877 76850 239528 229542 236511 20613 56424 56717 11798 13653 213988 217351 214150 15184 99982 217864 116871 116870 20583 14056 252870 17454 433759 56716 15182 54484 23797 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME DATABASE ID RELEASE 96%5632968 Defective Mismatch Repair Associated With MSH6 17685 17688 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203641.3 NOSTRIN mediated eNOS trafficking 73178 18127 13430 12389 329416 HATS ACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 96%3214847 HATs acetylate histones 21427 15161 109115 66233 58523 269424 78656 73247 225895 319149 74026 20174 77766 54351 74195 72341 217031 107435 226976 230233 208146 77853 269003 21761 76719 15077 76901 17692 102162 223527 140858 56790 382207 56397 69612 11461 72195 101206 28019 27878 13486 71777 217588 217127 108946 75565 228714 67773 245688 216825 621893 319162 100683 15267 319173 319163 319168 319167 75560 13831 268936 319186 319178 328572 319183 70088 319182 81601 228829 246103 108155 319190 17977 319176 56456 319181 17978 216185 108143 66464 56505 66262 12753 244349 12914 78783 11909 14534 319169 18505 18519 78303 319188 319189 64050 382522 PI5P REGULATES TP53 ACETYLATION%REACTOME DATABASE ID RELEASE 96%6811555 PI5P Regulates TP53 Acetylation 328572 23988 219024 26399 22059 18718 69260 108083 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 96%4839744 Signaling by APC mutants 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 DEFECTIVE SLC34A2 CAUSES PALM%REACTOME%R-HSA-5687583.4 Defective SLC34A2 causes PALM 20531 COX REACTIONS%REACTOME DATABASE ID RELEASE 96%140180 COX reactions 19224 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3645790.4 TGFBR2 Kinase Domain Mutants in Cancer 21803 21812 21813 HSF1 ACTIVATION%REACTOME DATABASE ID RELEASE 96%3371511 HSF1 activation 68275 68196 269523 68240 15185 19891 22627 100043508 15516 15499 15519 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.4 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) 19743 METABOLISM%REACTOME%R-HSA-1430728.16 Metabolism 68267 107508 13371 13370 70337 12389 213696 114479 16922 107585 22094 12908 214593 17117 99439 67528 66811 13142 106200 74114 12640 110959 22018 70503 18102 18103 229363 228061 27416 15112 22436 56185 214254 80911 76263 15452 13850 22017 12012 100042069 111175 14863 19193 23917 93732 14923 20280 67689 171210 11611 212503 56794 67224 15516 66999 13244 73690 11605 96979 20869 14667 18655 66612 108098 109652 66172 22318 20614 20907 192191 78334 73166 231070 270669 110196 14137 100040592 20683 66397 18044 18045 20933 18046 235293 68603 69608 218811 14732 99683 20775 20249 235623 192156 67131 170439 15484 72999 15483 13121 12401 20788 110695 13360 218865 107476 74129 100705 192166 14593 381379 55990 16987 14262 17764 71949 56453 75292 77371 101540 319554 67630 17855 230379 20334 67219 239559 53897 76893 66190 432628 74442 66183 171168 338521 20773 77626 26879 22234 14421 545975 14420 241447 104725 66844 56632 19012 50784 22239 18760 238011 230101 433323 76199 70059 208449 54447 670717 67260 67916 227102 268656 228677 93898 242083 223753 81535 70750 20397 76303 71720 228983 12642 15486 66065 114664 14187 99031 71240 100273 20520 17118 69718 227112 17330 57423 21428 53420 66477 11958 11957 11684 76491 11947 56362 319655 11949 20859 242291 68055 20860 23827 17705 73671 11946 29859 15526 20887 170442 66043 235386 11950 56442 192289 100041835 66194 100039108 71562 432676 69051 228033 209027 98256 209176 11847 100678 434437 53814 12716 107766 242669 76722 54375 26943 12715 20810 30956 230779 671878 75986 70789 229905 16514 56720 194237 217593 108653 67432 104174 83885 102857 76238 27364 19249 218442 23923 20229 209692 67092 229709 574418 16438 270076 16439 12971 266645 18747 107272 18247 18242 18245 12491 236539 56752 15930 18263 16440 22166 14630 76408 14775 17436 18104 14859 109778 233016 107765 12896 14629 12895 68041 19224 66198 264895 77219 14200 12408 14073 66834 18979 67420 57279 76187 330260 98314 269823 217666 70025 243168 71985 52538 72482 18803 11688 78245 69573 64292 102632 68680 14373 66469 228859 56360 330450 94185 171281 74156 245533 13167 223722 329910 195733 19225 11689 20927 76768 69060 109791 56045 76500 14411 234967 17254 20539 19341 20444 20442 20443 329416 14792 329502 66857 271844 67452 237625 665270 270084 53357 67216 68255 232889 225845 70625 68975 234959 69574 246696 68021 94112 11670 12350 12352 70208 12353 12354 56078 13849 76459 237940 23831 11754 67758 73046 109857 67712 22171 18105 14751 21877 71934 13361 67247 66394 56771 66112 50493 80509 108083 98386 14776 56310 26896 103988 19156 12857 110323 12861 12862 12868 66142 12866 12865 100041785 19211 333182 216456 380975 67279 59027 17992 18718 16866 11864 12289 18478 64384 70266 14204 110391 13180 66514 18534 170749 11816 59024 327987 20135 20182 69065 75475 13885 14872 54486 68252 66054 14862 14865 14866 68312 100042314 14874 14871 68044 68214 219024 78797 26426 68523 72199 26425 26371 67563 109006 69790 12858 14660 170826 20463 14381 14377 16334 75613 17708 17709 17710 14431 26379 20787 56508 264064 223864 84682 11863 20527 216154 51813 69792 20466 67381 19015 20602 23989 109731 28077 382985 171285 29875 27053 16993 15446 13087 13107 13106 622127 11624 11622 72303 107141 13088 13077 56448 13076 13114 74134 72082 13110 13113 545817 11428 27413 15369 19300 26357 18670 68421 28253 20544 230099 12040 12041 67725 13171 66422 13382 320685 12039 93692 55936 20133 66588 78801 51797 21915 11636 11637 229949 635960 79059 56520 54369 68870 64705 76654 72962 99586 103149 230718 268782 100017 50773 103850 68453 22271 93835 57875 13082 22259 16956 65969 232174 11303 546726 17252 66113 105349 13909 11657 18807 11807 11808 11632 16835 11813 11814 18749 15926 68961 338362 76969 74637 109754 328779 109672 23971 54338 23972 20522 319415 78923 11676 18682 14387 11677 18295 76898 68631 212898 14385 114332 56043 108105 66646 14595 15277 15275 17022 78752 75612 192188 50935 60322 269941 108902 80908 218271 14264 105193 14121 19746 545291 14120 70484 110078 22333 110095 19309 23908 15529 23888 20971 14635 74246 319625 224674 83493 20969 77980 14422 67073 54613 224020 56398 77116 14430 15587 216558 216019 15442 50917 16548 71951 20970 19139 54371 66171 71797 14735 12505 268512 100043349 71336 231583 53412 75456 19895 235582 212032 14043 14042 15531 226265 15530 77559 110639 13521 27419 73836 56336 56386 13806 103978 18563 235504 74241 66681 54616 16770 58193 80982 14733 21991 20524 53374 13070 83398 50786 17160 13808 77590 13807 108652 93683 13853 68365 68401 231727 20525 14734 116847 20322 319901 64580 117592 67883 59031 57370 53418 21351 56305 56375 215015 26878 26877 54218 50787 270198 18641 73744 18642 26384 12183 14378 18639 18640 170768 102448 76507 18648 71761 56012 107239 14348 15186 15366 15109 21881 243537 70974 140483 15118 67383 15117 14317 15116 64385 17159 21391 56421 19223 72136 13124 110173 100042622 58250 76205 18663 59045 54710 12257 628779 170459 235534 20845 225913 67980 50785 232493 14936 74185 27357 74468 110208 74551 11603 16545 233781 217119 227327 67880 14345 231103 53625 14344 14343 93961 11668 15476 72157 15478 27029 195646 17423 14347 280645 18679 56773 110094 102093 72727 234356 232449 67544 27047 230753 58810 11674 72141 230163 13072 15492 60525 15497 72535 13079 11529 68738 11522 26876 11532 11669 22227 12683 12686 15108 75894 18950 229665 109674 11717 105446 11534 11486 11821 66355 13178 27369 214424 328417 67287 80285 52552 671535 547253 18750 19092 18796 21990 18797 18795 17161 19084 19125 56189 212647 69089 12288 100042811 28250 107029 27418 70456 74125 16833 226757 76282 109801 16832 381511 68263 228026 18604 236900 27273 68477 75387 18004 66089 27402 68636 106557 18597 18598 382051 319518 16828 66771 55951 76425 59003 109264 235339 64436 18805 22139 624814 56384 22072 104158 68202 56491 108037 23945 75497 16890 19045 64899 21884 14626 14933 67469 215456 14245 19046 234729 103968 54384 66905 17772 64898 320981 13350 216724 12140 210376 16204 66569 16592 241274 14077 240752 233549 18705 67800 234129 14571 50767 68393 18720 14079 68616 14080 18719 75772 97287 11770 233315 11842 106869 107650 103199 244882 18711 12169 233552 268783 69769 74302 53332 219135 84095 319934 240753 101490 231999 109135 19062 269180 66443 234515 83435 83436 101476 56209 56409 75678 102954 27399 271424 227399 71207 327655 19087 238276 225742 20910 26938 19025 57357 50877 20454 11686 23801 625249 18010 23956 12709 13166 18948 21823 13195 17113 11840 13430 67768 108645 57344 67674 238505 11720 232087 210009 14873 269378 18113 12846 11551 11553 75669 225326 74159 12780 11364 67460 13177 66853 18631 68801 21835 14311 14081 20186 13123 104086 13122 77337 208665 101502 83702 21452 15288 22276 12892 17025 11655 11656 14151 226139 22275 19044 70383 14854 320634 20526 74411 74754 66234 18194 110460 68865 13595 15490 17001 67442 19088 234779 12499 73178 104110 14678 14677 432530 210044 104111 224129 11512 11513 11514 11515 15485 14598 16971 319446 23959 23887 19085 13479 12495 269437 104015 16330 16331 16332 269615 18798 18799 72469 18802 217837 228550 74055 320404 114875 104759 233011 212933 63857 55938 79235 170752 245532 65107 67861 239393 26940 102294 19662 19660 12894 19659 69923 19063 257633 433256 83603 74522 54397 50790 15487 328845 74205 57874 14979 30963 104112 106529 54325 66775 94180 216739 74559 234309 243078 70757 56348 99035 26568 54326 77582 56727 114663 55980 71780 212111 16329 103236 18127 64291 56473 76267 22273 66694 100042918 66576 53893 14297 66358 67530 75686 544717 56046 100040287 380840 17711 22272 66152 75530 67267 66821 100900 72795 107197 66445 67003 21743 214580 20768 211006 50880 20226 14711 65967 75420 20494 20493 106407 330962 26459 170460 71519 106648 100040843 13078 20751 71365 67426 99138 17979 320415 14528 242642 76889 217707 230027 67914 19286 56075 12850 71883 227683 52064 100043508 68268 22236 57813 67464 108147 69719 11564 11566 12496 12497 215446 14544 231327 237823 67365 72090 22247 80914 22245 68556 76952 381101 93685 11565 72269 56749 16434 67054 14450 56705 97212 11363 231086 12038 12647 11423 17961 94215 72094 213012 394436 12286 394433 22235 12290 71773 100727 100559 56808 231396 394434 94284 12296 552899 12297 223337 242585 243616 17960 14645 19215 99712 236899 12651 237928 56018 212862 12660 13026 76574 106861 18559 18618 69219 114886 66427 18777 21762 22123 20598 67041 58994 19179 64059 19181 69772 19182 208982 23996 110446 19184 15360 78894 26440 71911 19166 15356 13190 50500 19167 22293 18431 26441 22173 22178 26442 69077 74776 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 117147 22260 20181 22337 19013 19883 18783 59004 19016 22196 100043429 240332 19141 19731 269400 20597 18739 237911 74596 19679 327958 52858 74121 18971 26922 22229 22228 20523 74011 13075 109905 17164 217214 11898 109900 227231 18408 18416 67824 11846 19014 229003 11865 52466 328572 15368 21372 109151 11806 17977 238055 19017 18143 30960 17978 59035 81004 66826 66993 19301 24001 12753 15183 20185 217166 12914 15929 56406 67105 640703 74147 11429 171282 11666 68033 26458 15488 12856 113868 170789 26378 12974 67264 100434 213603 242259 229517 70129 66885 68682 12035 12036 66948 58875 104776 14697 12671 14710 14699 66066 14700 14276 14708 14706 110826 14704 14695 14652 14693 64337 14709 14701 14702 12182 14696 14527 14526 14688 29873 68133 13003 110006 77042 15586 109685 70893 15212 15211 12032 13179 15932 12091 11881 15931 12111 121021 13004 244757 19047 19386 73699 107146 233799 233801 272428 435528 19052 19053 51792 445007 64918 246277 21770 66902 14261 12583 57294 12411 67870 211389 12116 67873 14719 14718 66071 73748 70316 107869 56369 104923 27376 246221 17721 211488 17722 22117 17716 56551 17717 59010 17718 226654 17719 79196 237542 69912 28042 70568 85031 74182 105501 103468 27281 102278 67078 71760 74451 12891 75320 234865 66461 68671 218121 226856 320951 59015 66586 69736 668257 192654 74486 116939 66727 110379 266692 110911 67103 320997 13120 11690 631304 11687 13118 72054 17250 19210 208285 27388 13871 110821 66904 17850 73724 109136 104816 11484 269642 72560 68165 14149 14148 77697 109129 67096 18181 75778 13081 108156 17769 11433 216225 319945 71707 67375 52710 246703 225994 68591 107747 103711 69568 27973 29807 17434 74080 68646 110948 104709 78914 66473 69564 268566 105663 11761 230125 102570 223646 66454 54219 26363 67512 100039707 108079 14712 192185 18779 20509 239759 69698 26971 69372 108097 333433 69906 108958 17768 99010 54391 210992 116914 14555 270685 26970 20425 26565 67993 215708 67795 102247 226518 18784 216188 18782 14603 78390 216134 66350 67283 231510 665563 52123 12494 114874 67895 28169 76429 68262 66659 18806 55979 225010 18778 72297 18108 320207 58805 11651 68465 11450 72674 18710 11886 244209 11298 216343 13001 13000 100039026 11520 228775 108099 30955 18708 18709 18107 18706 74769 18707 436059 72947 11409 93747 15107 20216 271457 12346 12349 12351 14466 240444 30805 14675 238076 14672 14447 14676 22059 16500 268345 14682 20698 170762 108989 231042 227699 223921 227720 269113 66679 18141 107939 69482 71805 11739 54563 19069 70699 72787 18226 218210 11370 229211 27207 225887 67097 72900 670832 226646 17995 633683 595136 20044 623286 27050 66706 667279 235169 20085 78330 668144 67899 20084 210582 67186 170718 382492 66359 20055 52469 75617 66349 27370 76916 65019 69802 629957 75406 20102 67834 269951 20103 66945 668668 73694 667739 66343 66072 66841 672214 94281 66052 66481 67680 225058 66925 100038875 110842 100038991 74316 68028 70207 100043000 231430 67891 20930 100043295 66271 622534 67876 238217 66690 76826 16785 69702 666669 66278 100040021 208501 67025 54405 100043391 17991 668182 66091 241053 14194 69487 432502 110198 108755 71522 66272 19989 207182 239760 76808 71670 56451 19899 56615 68015 100043184 211666 20916 19921 66447 66414 19934 20917 100043755 67388 71238 68332 66379 319195 68472 100043209 104130 68193 75597 621100 66928 19941 18115 665189 15159 666899 68493 100042670 76947 15519 67044 100039316 67273 22121 68198 16211 66495 68002 67130 66416 68375 100043876 66108 100043893 52892 100043423 66836 100042986 68342 20115 76178 67281 66377 68197 76846 227197 625646 67184 100040298 100042503 68172 66046 100042740 230075 19951 66916 66218 15233 234724 19384 15445 667618 14085 100040970 267019 56040 67248 100040331 67941 11606 13116 13115 14104 110115 74450 56050 73095 18984 71743 75735 68087 211347 67618 269614 106564 72621 66812 73132 26464 22361 18605 18606 330064 209558 233081 26457 18293 78920 78038 243382 227095 11992 72039 56357 58911 22021 271970 67902 22022 545260 11883 74008 77041 216820 68346 14661 14473 94224 13074 78925 18704 107045 18717 15473 226414 257635 97541 231691 216443 105148 231872 20975 66143 14725 18976 104458 71803 67863 78830 85305 50799 17449 13722 17448 REGULATION OF HOMOTYPIC CELL-CELL ADHESION%REACTOME DATABASE ID RELEASE 96%9759476 Regulation of Homotypic Cell-Cell Adhesion 233833 20665 12388 232440 19089 12387 13200 13626 11735 12550 319149 20586 19645 20779 13858 15077 104836 13345 12330 20901 21417 60611 52615 16601 114142 19646 26413 26417 21418 13001 13000 100039026 17869 245688 18109 22160 16480 22330 16600 66357 53325 17246 66286 228839 18550 18553 69019 93759 93760 13430 21762 56529 22123 19179 19181 19182 67956 23996 19184 105837 26440 13017 19166 13016 19167 15220 26441 26442 69077 66997 23997 56436 17463 57296 20422 24136 26445 26446 20683 19172 19173 19175 15376 19177 26443 26444 22431 21423 19170 14694 75339 66413 192173 667035 22190 59029 230738 18746 67089 76007 56805 21406 70247 21885 18554 227485 15267 319168 56198 319167 13040 13030 76850 77630 239528 11492 319186 239096 12385 319178 59058 319183 110751 319182 12564 15426 66624 16201 236511 20613 319190 330914 12552 57875 15227 319176 319181 20014 213988 103963 217351 214150 69038 13135 99982 76687 228913 20583 14056 18717 17454 319169 57377 625328 78303 319188 15270 433759 217734 99011 15182 624153 16430 14376 382522 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 96%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids 15107 20216 11370 97212 11363 231086 11364 26922 11409 93747 SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209931 Serotonin and melatonin biosynthesis 21990 13195 11298 216343 DEFECTIVE ALG6 CAUSES CDG-1C%REACTOME DATABASE ID RELEASE 96%4724289 Defective ALG6 causes CDG-1c 320438 DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 96%3560801 Defective B3GAT3 causes JDSSDHD 15529 11603 23888 20971 12111 121021 13004 20969 15530 14734 103978 71951 29873 20970 13003 14735 14733 72727 12032 13179 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME%R-HSA-8849469.3 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 20459 13448 667035 22190 69710 12402 11651 ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME%R-HSA-167242.4 Abortive elongation of HIV-1 transcript in the absence of Tat 20020 231329 20021 69241 17749 58202 100043714 68092 27632 24116 20924 433702 20922 68705 98053 66420 69833 67655 67710 245841 69920 57314 20022 DNA DAMAGE BYPASS%REACTOME%R-HSA-73893.3 DNA Damage Bypass 76843 22230 56791 59001 74153 19687 100038882 19718 56438 69263 22224 19714 66979 244666 269523 71890 26447 56210 68026 216835 667035 22190 68098 18538 68275 106344 72151 18971 68240 18972 19891 18973 18974 80905 67967 217069 217365 27015 99375 69745 22210 72584 58186 230484 13194 67561 DIFFERENTIATION OF NAIVE CD4+ T CELLS TO T HELPER 1 CELLS (TH1 CELLS)%REACTOME DATABASE ID RELEASE 96%9942503 Differentiation of naive CD4+ T cells to T helper 1 cells (Th1 cells) 57765 21926 20849 18018 12399 22022 16162 15978 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 96%5693579 Homologous DNA Pairing and Strand Exchange 12021 81601 327762 20422 19361 114714 22427 19718 69263 15574 11920 12189 12190 235610 231724 237911 19355 57434 225182 74335 26909 235559 12144 68275 106344 72151 68240 233826 19891 19367 19356 19362 12649 19360 17535 21975 19363 19364 27354 MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%6791226 Major pathway of rRNA processing in the nucleolus and cytosol 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 55989 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 66362 67248 109075 100040331 66583 67941 27998 72544 50911 69639 72662 66446 227715 57294 104318 56200 72515 67676 27993 102614 50912 67619 66878 217109 110816 66138 229504 208144 67276 67973 18114 18572 78394 53414 216156 269470 59028 12181 21771 75273 215193 64934 217995 73674 67755 68272 213895 76130 216987 66249 353258 56095 71340 224823 102462 69072 213773 105372 67205 27373 72554 104662 67053 52705 230082 223499 269536 80886 70683 100041622 97961 24128 66164 27966 57750 74035 100608 100040177 234374 667035 30877 75416 57315 14113 68979 208366 227522 14791 57316 67045 54364 72198 65961 622491 68533 67134 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 SARS-COV-2-HOST INTERACTIONS%REACTOME%R-HSA-9705683.4 SARS-CoV-2-host interactions 16451 56208 16785 67443 78610 216799 22628 100038882 11651 12389 11652 15519 100039316 100039592 19386 54401 55948 20115 76846 100040298 233870 378425 267019 218978 218035 15516 445007 67941 18607 57294 269338 16172 22365 69912 80743 12914 28185 103468 15977 234865 71586 230073 66641 12675 71956 228607 59015 12695 217069 69736 224912 77573 14609 56217 110379 22627 24088 21897 75669 257630 56480 54131 225326 66397 107686 384091 171095 666609 216766 16150 15006 69608 218811 621705 21872 20595 16151 99683 66603 53975 192656 240095 276919 667803 20641 16179 23881 667035 20638 225913 69731 432803 26409 27041 67332 14991 257632 77371 20334 100039786 107607 20390 108960 12785 170743 228545 15007 170762 12010 108989 170744 231042 227699 223921 227720 269113 66679 18141 107939 17195 69482 71805 73158 54563 22031 71732 56489 19069 70699 72787 18226 218210 54721 72512 54123 233405 20847 66513 93765 66589 19247 22034 27207 15975 67097 66724 670832 68652 633683 16171 20044 27050 667279 15170 20085 668144 20084 382492 20055 22631 75617 27370 22629 629957 20846 20102 20103 668668 667739 66481 225058 100038875 23797 AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.4 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 73804 19053 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 18817 110379 69928 13427 76499 13426 52504 13424 228421 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.4 Aquaporin-mediated transport 14702 11998 14696 11833 19088 12000 11828 19087 19084 11829 11830 11831 104110 14697 66333 14710 432530 14699 210044 66066 104111 14700 14688 18747 14708 17339 14706 208760 14704 11832 53869 64008 14695 11827 224129 11512 14693 11513 11514 64337 11515 14709 18749 17919 74998 14701 11826 19085 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 96%5173214 O-glycosylation of TSR domain-containing proteins 66548 330267 207596 224697 56229 239337 77794 279028 80294 108153 23794 30806 108154 210417 271127 229595 208936 77739 381694 269959 100689 233744 235130 240322 20357 11504 20356 18636 21826 226866 21825 240913 223838 237360 330119 216725 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 96%5602415 UNC93B1 deficiency - HSE 54445 142980 CELLULAR RESPONSES TO MECHANICAL STIMULI%REACTOME%R-HSA-9855142.1 Cellular responses to mechanical stimuli 20750 12387 12562 19697 19087 19084 16150 11651 16151 14697 54598 14710 63873 14699 66066 14700 14360 18747 14708 11350 14706 14672 18442 14704 16412 14695 22601 73699 14693 64337 14709 16416 19052 16402 14682 78757 21894 14701 51792 19246 54409 18709 18706 22330 58226 18607 74769 11535 18707 14702 14696 18613 12293 18127 15530 12295 12296 19088 12297 56489 56717 104110 109333 81904 227743 432530 55991 210044 104111 14688 640703 224129 109270 11512 11513 11514 71978 12675 11515 12306 20846 16410 12334 18749 14083 12336 14609 18033 69543 17387 18439 16542 14257 18035 56716 19085 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%3371598 Defective BTD causes biotidinase deficiency 26363 INFLAMMASOMES%REACTOME%R-HSA-622312.3 Inflammasomes 54483 15368 66824 216799 19697 18034 383619 268973 12362 18033 18439 22166 12043 67955 19200 56338 195046 55991 12048 11820 15516 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013508.2 NOTCH3 Intracellular Domain Regulates Transcription 328572 12914 15213 14534 15214 18514 18519 218977 18131 18128 67784 333639 19208 211652 15205 20846 270118 15208 19664 56198 12140 103806 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME DATABASE ID RELEASE 96%5666185 RHO GTPases Activate Rhotekin and Rhophilins 76378 100039683 14787 52428 11848 20166 11852 11853 22342 FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME%R-HSA-9615017.2 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 14377 54601 16334 11604 109648 56458 19017 110616 16006 433766 76184 103988 57264 14815 17126 17127 17128 67731 20466 20656 56484 18976 433759 20787 243743 64384 15182 12359 18534 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME DATABASE ID RELEASE 96%8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 56436 17463 57296 20422 232440 26445 20375 26446 19172 319149 19173 19175 19177 26443 26444 21423 19170 15077 66413 667035 22190 59029 67089 21406 70247 214162 11350 66671 17420 22601 12572 15267 319168 319167 16396 319186 319178 319183 319182 12400 319190 319176 14462 319181 14461 22062 14460 21349 319169 21762 22123 109594 19179 19181 19182 16909 23996 625328 19184 78303 319188 16825 26440 15270 19166 19167 17863 26441 624153 26442 69077 66997 23997 382522 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.3 AXIN missense mutants destabilize the destruction complex 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.3 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 18011 232232 13388 16449 240055 225164 20602 11487 54485 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 15213 56233 17869 15214 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 15205 19664 433759 15182 APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 96%179409 APC-Cdc20 mediated degradation of Nek2A 52717 99152 668450 56150 12237 107995 217232 18005 56317 12236 59008 66156 216080 667035 69957 22190 17222 75430 68612 52563 22194 68999 52206 100039535 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.3 Retinoid metabolism disease events 19662 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.5 Signaling by Retinoic Acid 20148 19378 237320 13082 98711 12903 56847 19682 242285 105014 232174 216454 546726 17252 11522 108841 26876 241452 105349 13382 16592 218772 19411 28200 20181 20183 20182 68263 228026 18604 236900 27273 11668 27402 18597 19401 18598 19015 12904 235339 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME%R-HSA-8848584.5 Wax and plasmalogen biosynthesis 245533 216820 228061 67420 14712 245532 330450 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-HSA-2173788.3 Downregulation of TGF-beta receptor signaling 68010 17872 19047 65112 14479 56424 170749 56207 17126 17127 19045 103573 21803 83814 75788 66313 21812 19046 667035 21813 17131 22190 20901 ATP-DEPENDENT CHROMATIN REMODELERS%REACTOME DATABASE ID RELEASE 96%9932444 ATP-dependent chromatin remodelers 232440 12387 319149 67155 20586 240442 13445 11538 269610 20588 106795 20587 22780 14025 22779 78266 228880 52004 15077 17191 233410 11819 22778 140858 622675 70998 14121 19646 234366 83766 16002 56811 245688 23942 17192 70802 101631 73503 12006 67772 328572 67959 109151 107701 239985 210982 105246 72047 243842 56456 17135 20833 66993 18104 18024 114741 22026 76246 71389 214498 12914 66317 212880 21413 93760 235497 66923 22083 17927 17928 54624 68479 20222 216848 14377 319322 27967 107686 384091 666609 12412 107932 70127 29861 68981 269397 21423 20639 19708 268996 20641 101943 20638 12055 81898 12054 11461 77045 20646 67332 21406 26992 22196 68094 83796 15267 83797 57376 319168 319167 66055 229542 319186 319178 319183 319182 67465 319190 319176 13018 72293 67958 319181 241128 320790 76479 75062 12648 244059 116871 13204 116870 76938 66125 319169 12417 625328 78303 319188 15270 433759 15182 624153 72057 77044 58208 18534 382522 ACETYLATION%REACTOME DATABASE ID RELEASE 96%156582 Acetylation 17961 17960 NVP-TAE684-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717301 NVP-TAE684-resistant ALK mutants 11682 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.5 PI3K events in ERBB2 signaling 13866 13649 18183 83961 100042150 12223 14388 13874 15200 211323 13645 18708 18706 ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME DATABASE ID RELEASE 96%1237044 Erythrocytes take up carbon dioxide and release oxygen 19743 15129 15122 20533 230582 266690 320635 12346 72017 12349 12351 11826 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9033807 ABO blood group biosynthesis 80908 14344 14343 DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.3 Diseases of Telomere Maintenance 22589 13163 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME%R-HSA-175567.4 Integration of viral DNA into host genomic DNA 23825 15361 101739 REGULATION OF FZD BY UBIQUITINATION%REACTOME DATABASE ID RELEASE 96%4641263 Regulation of FZD by ubiquitination 239405 228770 407821 14367 207742 84092 14160 14366 22416 14370 107515 192199 667035 22190 72780 14368 16974 16973 329252 TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME DATABASE ID RELEASE 96%8986944 Transcriptional Regulation by MECP2 233833 13388 19293 20393 20602 12326 14811 20674 94223 17295 12322 12323 22065 16179 108058 18387 19211 12325 18390 18747 14431 26913 19016 12918 20877 19246 268859 76850 239528 98386 19258 236511 21372 20604 15228 213988 81004 17260 14229 217351 214150 56310 15183 14800 20185 17433 15258 20527 640703 17454 12064 14812 20466 14415 14417 433759 15182 15194 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME DATABASE ID RELEASE 96%5250989 Toxicity of botulinum toxin type G (botG) 22317 22318 20979 VITAMINS%REACTOME DATABASE ID RELEASE 96%211916 Vitamins 546726 13115 13081 13082 244209 232174 INTERCONVERSION OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351200 Interconversion of polyamines 20229 212503 DEGRADATION OF CDH1%REACTOME DATABASE ID RELEASE 96%9766229 Degradation of CDH1 56436 17463 57296 20422 12388 26445 12387 26446 19172 12550 19173 19175 19177 20779 26443 26444 19170 13858 104836 14694 66413 667035 22190 59029 67089 70247 13040 16480 13030 12385 53325 17246 13430 21762 22123 19179 19181 19182 23996 19184 105837 26440 19166 19167 26441 26442 69077 66997 23997 UREA CYCLE%REACTOME DATABASE ID RELEASE 96%70635 Urea cycle 217214 11898 83885 109900 227231 18408 18416 67824 11846 68346 22059 11847 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2122948.5 Activated NOTCH1 Transmits Signal to the Nucleus 18011 13388 16449 240055 225164 12805 11487 54485 207521 11491 16450 18128 667035 22190 227325 13386 74198 18222 14357 19164 19165 100042305 208117 59287 100039623 76580 109689 216869 16396 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME%R-HSA-2299718.4 Condensation of Prophase Chromosomes 319178 319183 319182 12534 232440 319190 319149 19645 319176 14211 319181 15077 319152 70099 244329 76044 78658 319169 52683 67956 625328 15267 78303 18817 319188 671392 319168 15270 319167 624153 319186 382522 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME%R-HSA-8941332.2 RUNX2 regulates genes involved in cell migration 16402 223272 12400 17386 23797 11651 11652 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.7 Synthesis of Ketone Bodies 69772 208982 110446 15360 78894 71911 15356 RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME%R-HSA-167162.5 RNA Polymerase II HIV Promoter Escape 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.4 Vpr-mediated nuclear import of PICs 18141 23825 107939 69482 71805 54563 16646 19069 15361 70699 101739 72787 18226 218210 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME DATABASE ID RELEASE 96%75067 Processing of Capped Intronless Pre-mRNA 384091 666609 68092 433702 20638 243963 67332 20492 72290 116748 68219 98985 228410 54451 108062 67337 54196 83410 18789 51786 94230 74320 68188 54188 66899 269061 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME%R-HSA-427389.3 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) 216848 319178 319183 319182 232440 319190 319149 319955 110147 319176 107932 319181 15077 22130 19646 234366 116871 116870 245688 319169 12417 23942 17192 625328 15267 78303 319188 433759 319168 15270 319167 15182 624153 229542 319186 382522 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 96%442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 18747 640703 19088 432530 11514 19108 19087 19084 18749 19085 CALCINEURIN ACTIVATES NFAT%REACTOME DATABASE ID RELEASE 96%2025928 Calcineurin activates NFAT 640703 268373 19055 19056 18018 18019 19058 14225 18021 MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE (UPRMT)%REACTOME%R-HSA-9841251.1 Mitochondrial unfolded protein response (UPRmt) 13982 15510 107503 628438 11651 15526 20656 56484 193740 64704 15502 64384 18181 74142 12359 15499 DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 96%69416 Dimerization of procaspase-8 14103 22030 71609 14082 22035 21933 12370 19766 14102 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME DATABASE ID RELEASE 96%8847993 ERBB2 Activates PTK6 Signaling 20459 13866 15200 211323 13649 18183 13645 83961 100042150 12223 13874 INTERFERON GAMMA SIGNALING%REACTOME DATABASE ID RELEASE 96%877300 Interferon gamma signaling 16451 54131 18854 15006 16364 12322 240095 12323 667803 108058 12325 17967 26413 14991 26417 55932 56469 12265 74735 18753 22329 20821 19824 23960 19204 65972 229900 110157 246727 17318 17750 231655 19246 93679 15007 17131 12010 224762 16362 12505 236573 67525 16452 15978 54139 55992 16363 101700 12702 94088 80890 360213 54123 56631 16391 15980 22670 15979 319236 19247 15894 214158 14969 229644 14968 246728 15900 22608 229898 66854 15170 217069 27056 12703 14469 14129 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 96%8856688 Golgi-to-ER retrograde transport 28169 54160 74947 108148 16570 107338 66111 53357 73470 16563 16568 234663 213827 11844 68097 73804 67511 53598 56358 56444 67665 22428 56455 13191 12121 76895 12344 26951 18476 59288 16594 18475 229841 668303 16579 232943 19348 71819 16593 105785 16551 110033 209737 11840 74764 18472 235661 18195 108123 108124 270192 13427 19346 13426 13424 228421 17957 26934 240641 269152 16565 16564 16552 16580 16581 67023 16561 16562 72772 16558 70218 20932 75050 16554 286942 71116 16578 319991 16572 66251 224630 16573 16560 56447 54161 18783 77038 59042 69654 228998 68137 11843 19324 66913 12343 12345 100042773 20333 11842 16569 12340 50797 70349 16571 12847 54130 14423 226407 19330 76308 100042343 POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME DATABASE ID RELEASE 96%9615933 Postmitotic nuclear pore complex (NPC) reformation 103468 107939 16211 69482 71805 226747 234865 70699 59015 72787 22196 69736 18226 238799 110379 19384 170762 100088 227699 445007 69912 269113 SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 96%9635465 Suppression of apoptosis 606496 672511 13035 26413 26417 19720 71514 BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196780 Biotin transport and metabolism 18563 78038 110821 330064 66904 72039 107476 26363 100705 110948 72621 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME%R-HSA-1369007.2 Mitochondrial ABC transporters 74610 74104 56199 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 96%5545619 XAV939 stabilizes AXIN 21951 74493 SENSORY PERCEPTION OF TASTE%REACTOME DATABASE ID RELEASE 96%9717189 Sensory perception of taste 20278 18796 20266 546729 20276 21906 20277 387513 399548 20274 16518 110876 20269 72821 387353 240669 387515 353148 68667 14688 353165 387348 14695 268934 16440 56843 64337 83771 574417 14816 387347 57253 57254 110326 387355 83770 387342 387349 242851 387616 SARS-COV-1 MODULATES HOST TRANSLATION MACHINERY%REACTOME DATABASE ID RELEASE 96%9735869 SARS-CoV-1 modulates host translation machinery 16785 57294 667035 27207 67097 670832 100039316 633683 20044 27050 667279 20085 668144 20084 15382 382492 20055 75617 20115 27370 629957 76846 20102 100040298 20103 668668 667739 66481 225058 100038875 267019 67941 RESPIRATORY SYNCYTIAL VIRUS GENOME REPLICATION%REACTOME%R-HSA-9834752.1 Respiratory syncytial virus genome replication 15516 15519 COMPLEX IV ASSEMBLY%REACTOME%R-HSA-9864848.2 Complex IV assembly 67876 12866 12865 66278 100041785 17992 66272 67388 66379 333182 67044 17708 17709 17710 67105 12858 67899 210582 52892 66359 66836 12857 52469 76178 69802 68033 12856 110323 66343 12861 20463 12862 70207 12868 231430 226139 84682 20930 66142 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.3 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 12261 12578 PHOSPHORYLATED BMAL1:CLOCK (ARNTL:CLOCK) ACTIVATES EXPRESSION OF CORE CLOCK GENES%REACTOME DATABASE ID RELEASE 96%9931510 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes 12952 12914 214162 382056 19883 21425 20893 18143 19653 13170 217732 17691 12753 19885 18626 11865 18627 18628 217166 12953 CREATION OF C4 AND C2 ACTIVATORS%REACTOME DATABASE ID RELEASE 96%166786 Creation of C4 and C2 activators 317677 14134 17195 12944 12259 71693 12260 12262 667277 239447 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME%R-HSA-9033658.3 Blood group systems biosynthesis 14348 14345 14422 54613 14344 14343 93961 50935 80908 14347 26878 26877 54218 19746 20443 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN DNA REPLICATION, DAMAGE REPAIR AND SENESCENCE%REACTOME%R-HSA-9825895.3 Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence 12189 16881 17216 21752 17218 IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.5 IL-6-type cytokine receptor ligand interactions 16451 16880 12931 16878 100042555 18414 16195 16156 54721 218624 13019 12804 56708 12803 18413 16452 SIGNALING PATHWAYS%REACTOME%R-HSA-162582.13 Signaling Pathways 20682 15901 17202 17201 12389 76804 22094 12640 19271 28200 22325 15925 57257 246710 50875 19877 15381 83946 106504 109331 11465 12848 19230 17920 22352 19878 76626 56381 19655 53382 15516 100043806 269061 26891 56320 109711 12539 20462 17395 69288 242202 18552 18550 18553 21812 21813 12283 20869 64930 13631 75705 66508 545987 13685 13684 18655 54170 72149 208643 22084 52187 68576 66096 83409 74370 68441 19042 268706 69008 67605 227154 245670 11789 20683 19205 76936 14732 27061 20249 71514 13385 15382 70686 53310 13383 59013 14939 98758 14102 14251 22195 22035 16396 12370 19766 11797 14252 22030 56424 21933 11796 11798 50701 12028 71609 14082 56321 17827 72843 68653 67414 70827 214952 229877 170731 319939 217169 67299 223701 11937 11938 53313 223870 12322 12323 108058 12325 19249 19253 229709 16438 16439 18747 320139 19255 16440 53627 20218 13992 170771 110651 20112 12418 14013 12151 17165 19763 17246 54383 13619 20293 241915 12416 319152 19821 23939 12579 106766 16193 494448 21413 17877 26419 17878 30951 17927 12064 17928 14812 14388 21844 18212 208869 18205 107971 78405 18803 11839 12043 13645 12048 18011 13388 16449 240055 225164 11487 54485 11491 16450 12562 16798 68473 75723 50523 232157 56332 64010 56274 58231 17005 14694 51789 58220 15139 21885 12266 227377 13653 20514 19341 57437 20443 260302 22241 208884 12326 18039 14810 11472 23859 14814 17886 72565 16370 15213 16002 67268 16000 13649 21802 74126 55948 94093 23942 67484 218214 11815 17122 21825 320982 68151 104263 231821 14419 12070 12772 56433 21815 12768 30930 80901 71785 14747 65114 84112 21827 387512 16765 59289 21828 108083 12776 214425 12775 73130 12458 12991 12773 12771 170458 98386 18386 18389 14539 23925 19214 243270 239283 12702 387513 14462 19222 14427 19217 228839 18166 19218 19219 18167 16477 18168 14294 12802 56310 14293 72780 12801 14309 387353 387515 353148 12765 218772 227288 19411 14308 56838 57811 17773 80707 244701 353165 387348 14534 387356 19156 20605 19065 20606 19064 211578 80885 272031 12145 20609 20608 14428 19664 227289 75769 217212 208990 216152 19650 22439 17863 110326 83770 20132 140795 57349 17171 30878 216848 623503 232232 107522 17329 20290 17200 18155 55985 20303 109648 20304 18129 20306 18131 20296 20292 18132 20302 107932 57385 20295 20297 100039973 74191 100038965 170787 20299 13610 53376 56066 19211 20311 20312 20300 11539 11540 18610 68428 18619 16184 229791 235044 16183 11542 252837 66102 13611 100039786 22095 19712 330122 19713 14823 108073 268934 94226 108069 108068 20310 14825 353344 14429 14764 13603 11609 23796 83771 574417 387347 19246 57253 12777 57254 387355 387342 387349 226278 229542 12766 226304 387616 12705 321019 12778 381073 23988 110168 75805 436440 76854 12769 64095 15199 17283 230857 14763 54199 18718 70839 171469 16866 16867 227326 14739 12854 13349 14229 15945 70315 93836 67821 13866 12345 18519 21858 21857 15370 15201 16323 16322 21814 21808 118445 67903 17387 11480 17389 21809 18534 268977 16997 22632 16998 20750 68010 17872 320910 20393 65112 14479 108075 18854 16420 170749 56207 241226 84092 79221 11816 66105 21907 11350 20482 20481 81489 20183 20182 75410 17125 67384 17126 17127 17128 17192 66313 17130 17131 56744 103806 333639 22284 22608 13559 104394 75273 14634 14633 75788 16653 12981 16334 56458 21423 16179 18387 18390 13983 21406 14128 21937 16399 12366 16402 21926 56508 264064 223864 227290 18591 12843 20807 54601 12399 20604 12927 83814 15185 12142 15184 12631 14205 51813 12156 252870 15469 15205 18815 20466 19015 20692 22341 22339 22340 15182 71393 20602 20586 56374 381293 20867 83669 18844 270118 108670 12874 232339 14786 223881 208994 108686 66922 12005 227937 20257 67586 234366 71228 18787 68187 93840 11671 107568 56233 15214 194231 54519 29875 245684 22371 16416 110157 23980 14161 21894 215449 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 16706 242341 68775 15369 76252 11972 108664 66290 18002 11964 110935 11966 100039636 66335 11973 11974 74915 338375 21871 73834 114143 66237 11975 54411 27060 140494 22042 66144 56480 207521 77579 71960 13856 16885 16886 13171 13382 12830 12829 12828 21886 12827 227325 12826 13386 21888 74198 14357 30941 22029 12841 229603 22258 268749 12840 106025 74256 263876 245026 21929 12839 12835 12834 12833 30924 20148 19378 237320 13082 98711 11307 12903 56847 22259 19682 18453 242285 105014 232174 11303 216454 11771 546726 11772 17252 108841 71770 241452 105349 218203 78514 19057 232910 11773 11812 11813 11425 18749 16188 16185 12984 12982 16192 16191 14595 54613 19373 19374 14573 103978 15904 14585 20811 11481 12622 269275 11479 99377 329251 68458 17931 19283 19299 11668 16846 13654 259302 223666 14270 117600 20671 56489 71648 11522 26876 14256 116871 116870 17390 67470 27409 606496 17242 14257 19719 225600 17305 18750 224143 19091 140484 19092 17136 18587 68585 18588 18377 18099 235402 18796 21990 18797 56437 14686 14066 18795 17095 14681 12570 15902 23938 268980 17172 54152 15903 14283 211770 19084 17936 17937 11682 11838 13656 13655 381677 54607 24064 17346 54426 68263 228026 18604 236900 27273 27402 18597 18598 235339 83490 27373 18596 93687 77647 18213 16456 21682 18762 16923 11848 17228 102098 19273 70737 71520 93742 14159 56513 14158 12057 23921 73086 18582 68146 22319 11855 277360 192662 263406 11857 14570 68813 19349 18805 624814 70584 56418 74334 56384 70361 233103 229658 544963 622434 16572 66251 16573 68202 12922 16412 545156 16443 13726 23943 75739 140579 628438 71782 17207 94176 330662 94190 16709 52331 218581 84004 21917 16324 56491 109904 238130 230972 20430 56419 380664 104445 56389 13836 59079 108037 69922 223435 330914 232906 56212 71435 228359 23945 19045 19046 103968 66905 12140 16204 16592 18720 18719 16410 14083 11352 53332 17974 20315 17925 14026 214230 13857 17973 12767 18186 23893 19087 12165 11705 20663 110542 218441 12154 241656 17129 71436 18121 18643 55994 18645 12166 12167 12168 11482 14314 19268 19280 21927 74194 64652 216197 12709 20355 233877 12223 229776 16589 71920 13874 13712 15200 18053 18412 19229 77125 74325 13430 69581 17082 238505 11551 11552 11553 80903 384783 240756 75669 94253 14186 213522 14165 329366 81897 56784 14389 20401 16367 233071 14172 75974 80857 12549 18576 58996 14170 66146 225326 214345 14180 208263 14178 192652 14177 239027 67112 70350 64654 74159 14175 71409 14174 74018 14173 106326 14164 244867 83379 70598 192192 319899 260409 16398 57778 386649 16400 226823 21763 216445 69710 211499 16194 244895 216831 268970 70719 328232 244418 101240 232201 73167 78816 228482 72729 104252 231532 68917 27360 69668 14218 71972 225358 214137 75415 171207 74734 71703 77038 228543 58804 56699 214804 269682 77006 223254 102075 66087 11736 23912 207425 19765 54004 73910 83397 269401 434204 207495 76763 94221 11858 213783 100038946 71085 545481 23853 210998 219140 226652 14787 11854 232237 27984 75089 76577 230654 66725 93695 75717 22192 22346 12703 54484 59009 17999 67588 75590 231474 18218 63953 13537 19252 240672 24105 106042 14587 14586 19197 14588 19262 15234 14181 72514 13017 13016 105827 195727 210293 50884 71709 18188 83767 170758 329165 109934 11876 106952 71893 13448 26934 110279 330177 75409 105855 242687 216963 386750 17969 20947 212285 237038 70497 320634 11308 20619 224480 11856 13058 241275 13057 108100 76117 218952 26431 17970 101314 17972 66898 71302 71544 13433 12261 18595 19164 19165 15208 100042305 208117 59287 100039623 56198 140580 19088 234779 19108 12267 76709 73178 104110 20963 14678 14677 12229 56443 14687 14679 432530 210044 104111 80987 68089 67771 11867 56378 66713 74117 13542 70086 224129 245880 11512 11513 11514 11515 13544 13543 22376 215280 68524 11541 242851 19085 58861 330319 76884 66894 72607 68031 73162 19720 21951 74493 14302 16186 18798 14680 55984 19417 19418 54393 211323 14402 14401 14400 14394 14407 14406 207565 57249 18752 236915 22342 242425 18759 192656 17874 14685 212541 17258 20203 20210 266632 100040260 101568 235584 67603 319520 72349 67095 73668 67661 207911 74682 73916 81896 77583 21821 83554 74201 20668 16568 234130 213081 73016 84035 228770 103236 56811 20680 24117 237222 14296 74499 207742 14160 20319 20377 20187 20675 20677 212398 100683 107515 192199 77578 68911 67772 380718 67087 80288 16974 13380 16973 20607 329252 73739 106633 72135 244585 20679 68339 239405 407821 18127 101565 27371 110350 230126 260305 16594 232943 245866 16593 74764 14797 73296 319642 19346 56382 51791 14608 67839 23984 241489 19049 67792 58175 18545 218461 18577 110385 238871 207728 54611 18584 67865 71729 18583 80910 381413 93690 238725 626596 192176 71223 239530 383563 76123 29863 14761 26385 106512 20851 20850 14784 67393 12648 320271 13033 99982 14228 18986 17979 193796 228913 13207 21887 15375 55960 268527 107351 26424 21786 22282 22278 100041004 100043508 18222 18016 76378 100039683 233406 68268 18187 12904 13429 12390 17393 22236 102193 67738 20739 20740 12805 640524 20742 20741 20743 103967 17967 80297 56705 50721 13710 399558 396184 56505 14254 18777 66552 76686 21762 432940 22123 20598 12675 52440 58994 19179 18201 19181 73218 19182 70178 23996 226016 19184 19671 18033 436004 26440 216169 19166 18035 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 66413 26965 667035 22190 18751 18654 59029 26409 67089 70247 22260 20181 14106 14313 66556 13982 11835 18753 14815 18783 110355 18575 208727 18574 19016 18573 19401 11489 244650 13498 18667 68877 98432 58988 15937 19731 218294 18611 140486 70727 21687 11600 18612 19732 81601 17532 76089 235072 171463 56392 67836 71746 14783 225724 16337 50772 20852 76983 12649 17179 18817 26563 216080 26564 22419 24069 100042343 12534 12388 12387 58194 12550 20408 12402 56324 20779 15239 20404 17295 20844 20405 13858 107746 109880 12929 26416 12928 56044 64143 18754 18049 18755 216148 320127 26413 76192 26417 104418 29857 56077 20416 66082 327826 231871 18211 380921 109905 110524 77480 269060 19094 110197 20418 217480 102626 13139 19730 331374 54401 116701 26415 140498 26395 212108 26396 19773 19762 242093 18176 381489 20662 239336 19769 16336 15461 23919 17164 52666 16800 263803 52428 13605 270163 20166 236920 13830 19014 16480 68743 20874 213498 70804 12704 243362 328572 110596 207212 19285 71704 234094 11464 21372 50768 56349 54216 16801 17977 11852 404710 13367 75547 103573 20868 268301 17978 320795 59035 109333 81004 72754 208846 17260 69632 17261 213649 24001 224014 230098 268903 53972 30938 15183 21390 20185 77669 442801 226970 235611 12914 54126 101497 14673 11909 269608 640703 328967 14163 19055 26382 19056 268739 19419 14674 18018 73341 11550 240168 11853 19058 11548 14225 11549 56484 16476 16542 16906 22627 12569 12568 11820 12125 14103 12532 20459 11554 11555 11556 15560 15559 15558 213788 18128 15557 56438 13492 57265 382348 13733 13491 381853 13490 14607 13489 22226 13488 14697 111174 93897 215855 19206 503558 54598 215854 22412 12672 216795 12671 19226 15552 14710 15466 14699 15551 66066 15550 14700 243764 22410 12669 93896 15465 22414 99296 22411 18241 14708 209512 14706 15566 22409 15565 12310 15563 14704 15562 11516 225192 14695 19060 14652 11517 12311 14693 20423 64337 14709 15874 12921 12919 22417 12918 14701 114640 223780 230674 54409 19227 19228 56089 213527 51801 13363 14602 14601 54198 319757 12385 11535 14702 93735 83428 14696 14527 20613 14526 14367 14365 18514 26364 218977 14362 67784 22415 19208 14366 211652 22413 21335 22416 16453 22420 22418 54721 14370 22354 22422 13609 14371 22421 22353 20287 14368 22423 14369 217864 22355 20890 19207 14688 22408 16147 110606 59040 26554 226525 18015 14272 320484 211255 240057 101809 54153 114715 114716 19342 19414 69601 19415 218397 114713 12575 360216 211586 13555 21781 12567 12443 12566 12445 13557 12447 20901 12576 14255 108911 73470 16563 75786 70454 216965 71876 234663 19047 15507 66977 320394 19386 102920 73699 11799 12015 52276 12371 12235 67037 20842 68097 16319 217866 19052 105782 73804 14269 19053 22379 51792 80837 20877 214459 381318 14467 24061 66871 52696 226751 26886 76088 66934 218756 18221 20732 445007 15451 19357 15235 226849 19882 225849 20733 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 13006 214498 18472 67733 103468 66468 76464 66442 67629 235661 235497 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 13426 52504 13424 228421 26362 20843 18429 11998 18430 54140 26361 12000 21873 13511 13510 21872 12367 109620 68705 98053 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 17749 100043714 620393 19242 15267 319168 319167 14281 224105 75778 76850 239528 319186 22158 319178 70300 319183 271639 319182 240888 14632 380614 236511 319190 241113 14282 56717 319176 216440 319181 19353 213988 217351 56637 214150 227743 19247 13819 66753 104709 14056 15170 116891 17454 20338 319169 14451 109270 57810 15245 117606 105787 108079 20846 19079 20848 108097 625328 78303 319188 15270 16818 19082 56716 624153 23797 382522 233833 16451 21415 232440 18806 13626 319149 22628 18183 12633 320207 83961 16478 100042150 16842 76890 22612 11651 11652 22324 15077 269523 66310 18710 19303 140858 97064 18791 52615 21752 19646 213464 14360 12988 68525 13001 59056 13000 74239 100039026 104346 17869 230500 245688 13206 20747 22601 15251 17096 12638 23808 14580 18109 17444 78757 228775 60533 76580 108099 12006 30955 12774 18708 18709 18479 18706 18607 74769 18707 12487 12519 12524 21414 21416 18481 68092 94275 21374 433702 107951 19354 20201 20202 12454 235459 83602 58202 12455 72949 14609 16001 12466 13051 12468 22143 12461 14675 24012 19739 50782 56327 50779 11461 14672 14676 22059 14682 20698 223921 67938 17904 107589 214240 226861 24063 17880 19272 16206 239463 94212 16419 59069 16952 19248 14425 16848 21803 21826 667739 224116 67300 12757 17063 14459 53978 11545 22044 22045 624910 57260 233571 235036 246709 13617 19734 30044 14715 15519 14714 13615 18441 246691 100039592 18442 14745 16963 16995 208188 229214 56183 56696 210198 58182 19204 104443 224065 19216 19220 64214 319239 14816 14289 12374 108071 238377 14744 225642 50778 19735 50780 19736 14829 67168 21333 11606 11607 12400 12061 14104 12062 17392 56470 216749 21338 19737 14064 65086 14063 14062 14061 21337 23832 319197 21334 21336 240816 12424 12425 12426 217369 227717 14065 381810 107221 280287 24111 574402 51796 78134 100043254 237362 385643 433292 53817 246313 233079 233080 233081 50501 67405 18216 14773 54615 12209 78826 114229 15171 110312 18217 387285 230777 14767 68039 18101 56533 22637 72345 20674 22065 22068 57295 26946 19277 16775 16776 16777 16779 16780 226519 14268 16782 16772 23928 16773 16774 319430 12478 12273 66573 71742 76857 13043 233489 100041766 66513 13854 18761 22034 19395 66724 20403 233046 68652 11845 20583 20111 18717 17169 13859 22631 320129 13616 22629 13614 106628 18976 17199 433759 13618 16590 93686 77411 21843 21841 17203 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME DATABASE ID RELEASE 96%168179 Toll Like Receptor TLR1:TLR2 Cascade 71481 26416 211550 26410 26413 26417 24058 117149 12491 19094 73914 102626 20193 73699 26395 110651 20112 17164 19052 14161 19053 51792 110135 99571 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 20201 20202 11909 26419 12675 16476 18033 18035 18036 24088 11820 21897 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 26940 266632 26401 80750 223664 107607 21899 69721 231130 93834 270151 11596 22059 67454 240518 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 22030 12475 67245 18034 12229 434174 66513 93765 66589 22034 66724 68652 20111 12703 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME%R-HSA-2022090.5 Assembly of collagen fibrils and other multimeric structures 18542 192897 69675 16403 12815 24087 12814 21892 12831 12153 12813 12830 373864 12819 53867 12829 12828 12827 12826 12825 12824 16780 12822 71355 12841 16782 18810 12840 16774 245026 13040 12839 13030 329941 12837 12836 12835 12834 16948 12833 12843 16949 12832 12842 94352 16950 67573 17395 13039 17392 17386 30800 12476 17393 DEFECTIVE ABCD1 CAUSES ALD%REACTOME%R-HSA-5684045.4 Defective ABCD1 causes ALD 11666 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 96%4641257 Degradation of AXIN 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 68031 26443 26444 21951 74493 19170 66413 667035 22190 12005 59029 67089 70247 21762 22123 19179 19181 19182 23996 19184 66313 26440 19166 12006 19167 26441 26442 69077 66997 23997 POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.3 Potassium transport channels 16513 56379 16517 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 96%5689896 Ovarian tumor domain proteases 12534 11848 360216 107260 22031 73162 16151 269523 192656 68149 667035 19211 22190 170711 54644 57783 22034 257632 226418 107607 13982 231130 71586 22059 230073 66889 71956 228607 217069 229603 414084 216080 21929 70675 11789 19766 PLATELET DEGRANULATION%REACTOME%R-HSA-114608.5 Platelet degranulation 11472 12331 18643 18787 239273 16002 16000 12491 12527 22371 16416 16784 14161 21894 21825 56744 110135 99571 22330 109711 54216 11806 667310 640703 385643 268373 19156 15234 22041 14828 19128 13645 11820 14456 72017 57349 22145 16399 14268 11818 27359 12258 21346 20716 268936 192176 18591 117586 11674 109232 71946 12759 215789 235505 67988 12321 11537 18613 26968 68038 20911 21922 20255 108101 218454 223601 12512 80718 16426 22138 227612 232345 60595 104009 320202 70945 53612 67059 11657 20703 11625 21767 19073 56541 74145 14067 12631 14205 80884 20344 68117 21859 74840 94175 13041 20363 11747 21857 16427 18815 56193 18816 21803 19039 21808 56055 13601 240334 14069 20692 22388 75396 22341 22339 18407 22340 11804 71660 67072 21809 66866 27999 OTC LEADER SEQUENCE VARIANTS CAUSE OTC DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9956551 OTC leader sequence variants cause OTC deficiency 18416 OPIOID SIGNALLING%REACTOME%R-HSA-111885.4 Opioid Signalling 18796 18797 18795 12326 14675 19087 19084 14697 12322 12323 108058 12325 18390 14710 14699 66066 18610 14700 26413 229709 16438 16439 18798 18747 14708 14706 14672 100039592 14704 14695 14676 16440 73699 18753 19049 18783 14693 110355 18575 64337 18574 14709 18573 18577 110385 238871 19052 14682 19053 14701 51792 14702 21770 14696 14680 19088 55984 19108 19045 104110 14678 14677 14679 432530 210044 104111 19057 14688 640703 19055 19056 224129 11512 11513 19058 11514 11515 18749 207565 18976 18752 12568 18750 242851 19085 SIGNAL AMPLIFICATION%REACTOME DATABASE ID RELEASE 96%392518 Signal amplification 14702 14696 14675 70839 14697 14678 14677 26416 14679 14710 14699 21390 66066 14700 14688 18441 14708 14672 14706 14704 14695 14674 14676 18783 14693 64337 14709 14682 14701 227290 242851 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME%R-HSA-983169.7 Class I MHC mediated antigen processing & presentation 20437 99152 636931 668450 328234 56208 76608 19823 227738 74153 22201 79263 22209 74244 53323 140629 68497 70620 330369 23807 140499 59009 17237 50788 22213 67128 433766 22222 224938 22214 17999 98766 67615 19155 268470 67588 59026 107568 230903 66772 208372 76454 70093 329152 117146 65247 22215 65255 67345 81018 84585 67731 217342 142687 209462 78910 231380 14161 65256 70392 69807 76580 244421 22036 224170 240396 225055 218978 24105 232539 110135 56515 99571 170823 215061 67138 19822 17087 74132 67490 231670 672511 13039 226098 69754 224619 77113 14897 59044 12702 207952 70348 320118 170737 70928 56228 30843 68854 76294 211007 21898 72323 399566 30945 68098 100763 214931 20201 20202 67923 106052 24088 242960 21897 30838 30050 50762 66397 17969 56438 15006 69608 218811 99683 22319 20619 240095 50754 13058 667803 13057 17970 17972 14991 77371 20334 213980 21899 68628 50789 30839 22195 50873 16396 56424 14827 16419 12229 434174 57743 218203 17534 21354 21356 21355 93836 53421 20909 100043039 246278 66212 26554 211255 16410 71745 22210 14129 12317 66105 56371 27401 12330 80751 117149 12491 20193 66313 80898 107995 22320 21762 22123 12675 19179 19181 19182 23996 19184 75788 110379 26440 19166 14828 19167 26441 26442 75669 69077 17533 66997 23997 12234 56436 17463 57296 20422 26445 26446 225326 19172 19173 19175 19177 21402 16150 26443 26444 16151 19170 17874 66413 26965 667035 22190 59029 67089 103583 70247 117589 78541 69299 218215 94090 233902 69116 208650 73998 50760 20821 235320 242521 209239 74492 75234 66799 72194 67845 15204 69706 235439 57751 15007 13040 140630 12010 94091 217194 16924 22019 226541 65257 104184 19820 78913 242785 56791 68729 69010 16912 211949 19171 66743 12475 233040 231672 18744 50492 224826 231863 101358 12449 224023 109161 16913 83814 22193 71538 76375 19186 67455 19188 14794 100041766 217217 216150 71999 269529 93765 83962 66589 230654 635668 240028 66515 269514 78889 69162 68431 230904 28105 71865 380928 20333 50868 207215 22200 627648 207304 75717 70294 67921 100041484 22192 66663 142688 217232 243574 56317 321006 59008 268291 209200 66156 74646 216080 448987 69957 22346 17222 56736 228003 68612 52563 12703 22194 212919 71393 68999 54484 52206 20439 100039535 218793 AGGREGATED Β-AMYLOID INTERACTS WITH FIBRINOGEN%REACTOME DATABASE ID RELEASE 96%9936686 Aggregated β-amyloid interacts with fibrinogen 14161 110135 99571 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%399710 Activation of AMPA receptors 53623 14799 14802 14800 CD28 CO-STIMULATION%REACTOME DATABASE ID RELEASE 96%389356 CD28 co-stimulation 225849 74769 53859 18707 26931 12487 21770 12519 26932 12524 18481 320207 56717 22612 11651 11652 19353 22324 18710 227743 26410 14360 104709 73699 109270 17096 19052 17444 78757 19053 228775 51792 16818 224105 30955 56716 18708 75778 18709 18479 23797 12477 18706 226849 18607 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.4 Translation initiation complex formation 16785 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 100039316 20115 76846 100040298 13665 67204 267019 26905 67941 57294 75705 27207 67097 670832 13684 633683 20044 27050 208643 667279 20085 668144 20084 382492 20055 75617 27370 629957 20102 20103 668668 667739 66481 225058 100038875 18458 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 96%2514853 Condensation of Prometaphase Chromosomes 13001 68298 13000 100039026 215387 12534 70099 12442 14211 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME%R-HSA-203754.3 NOSIP mediated eNOS trafficking 66394 18127 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.6 Activation of GABAB receptors 242425 14702 14696 14680 16519 16520 104110 54393 14697 14678 16518 14677 16516 14679 14710 432530 14699 210044 66066 104111 14700 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 224129 11512 14693 11513 11514 16517 64337 11515 14709 14701 242851 EPIGENETIC REGULATION OF GENE EXPRESSION BY MLL3 AND MLL4 COMPLEXES%REACTOME%R-HSA-9818564.3 Epigenetic regulation of gene expression by MLL3 and MLL4 complexes 232440 20602 319149 23989 19645 66853 59024 11450 14732 18631 327987 15077 57435 20249 68801 66310 21835 140858 14311 68975 14081 234959 213464 12606 20181 11350 28077 70208 12491 21664 55982 171285 23808 11520 56771 15267 319168 319167 19014 264064 319186 319178 328572 319183 319182 67279 319190 21372 16475 231051 57875 17977 67278 23945 319176 19017 16890 16956 319181 17978 81004 14245 69790 56310 103968 26896 15183 20185 93759 17979 216154 67800 12914 56406 51813 11770 26424 319169 22289 27273 69792 67512 625328 67381 78303 319188 15270 170826 12568 624153 381022 382522 SIGNALING BY PTK6%REACTOME%R-HSA-8848021.4 Signaling by PTK6 20459 13448 11848 12402 18183 83961 100042150 12567 12443 11651 12566 12447 19303 667035 22190 12928 69710 12576 71514 13649 20218 13992 14815 170771 15251 140579 18176 15461 330662 19246 140580 232906 12223 12702 13874 19353 12927 15200 211323 13819 20811 66725 106766 93695 13866 75273 218397 20848 13645 APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 96%75153 Apoptotic execution phase 12387 12550 20230 21873 13511 13510 27061 21872 12367 18772 109620 13512 227753 269582 16211 18753 19877 12369 14453 11518 13169 18810 12368 22352 56702 224105 50709 14957 12370 50708 14958 11797 80838 13368 16646 13347 97165 434174 70415 18761 223255 56215 74006 14272 12169 14083 16906 11789 20740 FIBRONECTIN MATRIX FORMATION%REACTOME%R-HSA-1566977.5 Fibronectin matrix formation 14268 16402 16412 UBIQUITIN-MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.6 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A 12234 93687 56436 208583 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 26416 22190 59029 67089 103583 70247 19094 12795 50883 56637 21762 22123 19179 19181 12649 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 12530 23997 27373 INNATE IMMUNE SYSTEM%REACTOME%R-HSA-168249.12 Innate Immune System 53381 70450 12654 13014 102595 170813 14190 74153 12796 76905 67912 53328 74244 71728 53323 76025 229574 12508 12514 78892 68724 26949 232413 27261 433375 235627 19074 19271 19263 18126 72461 18103 17523 70152 52633 217353 19276 69981 22325 59026 667301 231887 72042 69660 71869 72065 394252 100042069 78388 21946 23917 16970 227960 57257 67689 74287 223978 19877 100037283 11571 208795 380924 245126 11465 20568 383295 69807 241197 67213 18813 83768 69189 17025 18703 268379 107767 15516 100040018 13244 93726 54159 56318 55950 70536 17395 21930 100040603 56444 20195 212114 53856 18600 11593 74039 73690 56016 18475 545878 16783 80796 54672 108888 17064 11605 56031 66222 96979 69550 13861 12283 20972 71517 69537 381812 14667 66508 16678 545987 19264 80860 67862 66612 20409 28185 74012 19288 76299 66060 14824 83409 83433 108015 18521 22177 20614 50884 24088 83767 21897 329165 23845 105855 242687 17969 15006 11308 20619 13058 667803 13057 108100 17970 101314 17972 21899 12261 56485 19164 16176 12362 59287 12363 15162 140580 17002 16396 12370 19766 11797 56532 16173 22030 67245 69146 234779 11796 17918 50701 12267 76709 53378 73178 20963 54722 434174 12229 56443 14082 19200 13205 80987 68089 67771 11867 54483 56378 66713 74117 245880 14191 22376 215280 18439 68524 67955 13035 17882 14129 17913 246256 14131 17909 66824 330319 216799 76884 14302 229709 16438 16439 24058 18747 117149 12491 73914 18125 20193 16440 104759 110651 20112 620235 19695 22166 74096 18489 12652 16429 18843 19194 78416 228801 57757 242100 26399 11927 26400 26398 26420 259301 26414 26397 228796 76113 11758 75526 384997 23939 15977 26419 18803 12043 12048 13629 11487 192656 17874 17258 20203 18746 20210 24110 11689 257632 26940 266632 15139 26401 14962 80750 12263 223664 12266 53791 625018 107607 69721 231130 93834 270151 11596 67454 240518 71966 108960 67781 59025 100040260 101568 232714 235584 67603 319520 72349 71884 104112 71955 57437 108995 19089 53357 66848 66557 17886 71481 211550 14751 12772 12458 13038 22154 13039 18127 16854 13036 67065 74414 226977 14293 78929 12765 26939 227288 67486 70408 20018 69870 70428 218832 67005 20016 19156 12909 16004 319642 19346 57349 330122 80910 23988 19258 13033 12343 57264 12340 21858 18016 11783 13429 69562 20740 103967 66105 269116 72269 11350 58992 19339 16621 13002 21762 22123 12675 52440 108723 19179 19181 19182 23996 268973 19184 18033 26440 19166 18035 19167 18036 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 12042 66413 26965 16179 667035 22190 240354 59029 26409 67089 103583 70247 16408 14127 18753 21938 12366 170743 13040 19141 56338 170744 13030 17535 22027 20716 54445 227290 12359 142980 667277 117586 239447 317677 14134 17195 12944 11537 16904 18613 12259 71693 12260 12262 19090 384309 22040 383619 12512 72162 72935 72512 54123 68891 20852 268857 22596 104009 13211 14375 214763 20703 11625 20527 12631 56619 332579 26888 56644 94175 381809 17312 56620 17474 13032 245828 216080 333883 18407 12387 26416 12928 18754 26413 26417 29857 109905 19094 102626 26415 26395 18176 29875 20662 15461 17164 110157 13169 14161 215449 11846 13830 16480 13505 110135 99571 22330 328572 15129 16993 17087 15368 238055 13367 20868 30960 17260 21898 242341 68775 15369 76252 11972 108664 66290 12914 14325 11909 640703 11964 268373 19055 110935 19056 11966 19419 100039636 18018 66335 18019 11973 11974 19058 74915 18021 14319 338375 21871 73834 26458 16476 114143 113868 66237 11975 27060 668218 16819 77674 11820 140494 654464 266620 654459 75400 66144 246700 71902 246082 654460 654465 12333 244332 56480 629114 446099 54131 207521 58203 68682 67526 11793 16885 54644 74256 21929 12182 58222 67963 26364 11772 232345 381925 18807 71910 12798 17319 19342 19336 70349 18749 15926 110006 109754 15212 11676 14387 12091 11881 14595 75612 18793 227753 110078 110095 109154 73699 12371 18436 19340 15442 50917 19052 19053 51792 12505 66934 212032 21770 56455 77559 71665 66681 231507 70568 19325 68365 235661 216238 71398 27056 78287 266692 19128 217303 18641 67474 13424 19152 76507 18648 17159 13510 15439 12367 110173 18772 109620 11891 225913 66420 69833 245841 27357 20932 17749 11977 100043714 16409 72157 16423 16411 16414 15267 319168 319167 14281 224105 50770 105722 232449 319186 11674 11980 319178 319183 319182 319190 12475 22031 56489 225471 106759 319176 21353 76295 18034 71648 319181 19353 19247 18950 15170 11717 235606 319169 223646 11821 67075 67512 625328 78303 319188 210992 15270 16818 624153 216134 382522 53859 18806 13200 319149 22612 22324 15077 269523 20719 11886 18792 26410 14360 22165 13001 12502 17096 12504 76501 16784 17444 12238 18708 18709 18479 18706 18607 74769 17394 18481 19354 20201 20202 240047 11501 74125 71586 230073 66641 71956 228607 217069 19345 19344 19261 108078 20343 12469 12461 21682 58217 11848 19698 15896 73086 170786 227613 13010 11461 51788 19349 18805 22139 52588 668101 11870 217304 22072 544963 217306 16643 232790 16498 22059 140579 17380 16790 94176 330662 70495 52331 52855 83382 20430 27007 17079 16803 329547 17084 56212 55991 13350 16592 269328 12306 16410 14083 17829 18636 100039649 140474 224116 17063 17925 73732 17973 353328 100038882 56615 12331 193740 15519 16211 100037258 19025 19204 68197 14289 20813 18010 216197 72621 14061 13712 22361 22320 100561 15481 385643 105245 64138 13430 54473 16822 75669 81897 14389 16428 56743 225326 227394 18173 28240 216445 70719 11883 69116 14126 14125 20821 22370 230558 319430 195046 12010 12258 110382 12478 12520 69379 12279 50702 11767 12628 23912 71756 12759 12630 56791 93721 12273 12274 545366 17221 56373 76763 12902 109828 100041766 216150 66513 76577 93765 66589 18761 22034 19395 66724 233046 68652 52120 20111 14569 22200 106572 22192 80861 108086 12703 19330 224794 67706 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME%R-HSA-5651801.3 PCNA-Dependent Long Patch Base Excision Repair 68275 106344 72151 18971 68240 18970 18972 14156 59001 11792 19891 18973 18974 19687 19718 69263 67967 66979 16881 69745 18538 REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%2565942 Regulation of PLK1 Activity at G2 M Transition 12234 20873 68121 12534 78887 22628 21402 225745 231123 227613 74360 22153 26965 18536 667035 22190 22142 66296 214552 103583 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 16475 101565 19088 16328 219103 230376 69654 71648 17274 83922 75296 26370 19046 76707 77744 219072 13589 225659 18472 76478 78177 28135 12442 214444 76816 20878 54130 18817 381644 13427 22627 17931 13424 27373 FXIIA, PKA ACTIVATE COAGULATION FACTORS%REACTOME DATABASE ID RELEASE 96%9935598 FXIIa, PKa activate coagulation factors 385643 58992 16621 14071 14723 14724 54368 14729 109821 DNA REPLICATION INITIATION%REACTOME DATABASE ID RELEASE 96%68952 DNA replication initiation 66979 18969 18968 59001 19075 19076 18973 18974 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME%R-HSA-5663084.5 Diseases of carbohydrate metabolism 19895 230163 11881 14377 15931 14385 27419 75612 667035 105193 22190 232493 14936 74185 27357 52120 13853 67880 68401 69983 50917 27029 16548 21351 110006 226413 15586 14387 53412 15932 12091 FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME%R-HSA-196025.5 Formation of annular gap junctions 14609 67300 13429 11773 12757 13430 13132 74325 SYNTHESIS OF CL%REACTOME%R-HSA-1483076.4 Synthesis of CL 66586 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME%R-HSA-194313.3 VEGF ligand-receptor interactions 14205 14254 16542 22341 14257 22339 18654 22340 ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 96%3371568 Attenuation phase 328572 12914 81489 100043508 68196 193740 14228 15516 15512 15481 15499 15482 15519 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 96%68875 Mitotic Prophase 12534 232440 319149 19645 15077 18751 26413 59046 244329 59021 382030 67121 56205 52432 76044 19386 78658 73699 13726 66352 59125 67181 59126 52683 217718 70231 19052 15267 19053 51792 671392 319168 319167 170762 108989 231042 227699 223921 445007 227720 319186 269113 380664 66679 319178 18141 319183 23825 319182 107939 69482 71805 319190 54563 19069 319176 70699 72787 18226 319181 14211 64899 218210 319152 14245 70099 101706 64898 19324 69912 103468 22367 319169 224640 74498 234865 12442 59015 69736 67956 625328 78303 18817 319188 110379 15270 56041 16906 18750 624153 99412 76308 382522 SEPARATION OF SISTER CHROMATIDS%REACTOME%R-HSA-2467813.4 Separation of Sister Chromatids 52717 99152 668450 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 30939 218914 12235 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 100710 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 21762 22123 60411 66336 59015 19179 69736 19181 67052 19182 232987 23996 12236 19184 236930 110379 26440 69928 19166 13427 76499 19167 71521 13426 26441 52504 13424 26442 228421 69077 20843 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 105988 217232 56317 59008 18817 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%3000170 Syndecan interactions 15529 20971 109711 60409 16412 20969 21923 16410 14173 16416 21803 16419 192897 20970 16398 21825 12361 22370 16403 18750 L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME%R-HSA-156827.5 L13a-mediated translational silencing of Ceruloplasmin expression 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 57294 75705 13684 208643 13682 13681 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 22384 54709 100042807 98221 66235 13665 67204 26905 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 18458 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME DATABASE ID RELEASE 96%5579017 Defective CYP11B1 causes AH4 110115 TGFBR3 REGULATES TGF-BETA SIGNALING%REACTOME%R-HSA-9839389.1 TGFBR3 regulates TGF-beta signaling 21814 21803 21808 67903 21812 21813 109689 216869 DISEASES OF HEMOSTASIS%REACTOME DATABASE ID RELEASE 96%9671793 Diseases of hemostasis 14067 19123 14723 279028 109821 22371 14061 14161 22021 14069 56316 19128 14058 14071 105722 14724 22022 54368 110135 14729 99571 BCKDH SYNTHESIZES BCAA-COA FROM KIC, KMVA, KIV%REACTOME DATABASE ID RELEASE 96%9859138 BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV 12040 13171 13382 12039 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.5 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 14389 74769 16367 14172 80857 18576 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 327826 16370 16002 16000 18176 14388 20662 15461 16001 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 214425 18607 REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME%R-HSA-159782.6 Removal of aminoterminal propeptides from gamma-carboxylated proteins 18550 19128 14058 14071 19123 14068 66901 14456 14061 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-HSA-5654699.3 SHC-mediated cascade:FGFR2 14172 80857 14180 14178 14177 67112 64654 14175 18176 14174 20662 14173 14164 15461 80903 14165 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 96%193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol 26459 26458 17117 13116 105349 56050 104086 77337 208665 101502 83702 13124 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%264642 Acetylcholine Neurotransmitter Release Cycle 63993 233977 20508 12647 19339 22318 20614 20979 68507 20907 327814 12889 22249 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME DATABASE ID RELEASE 96%432047 Passive transport by Aquaporins 11831 17339 208760 11832 64008 11827 11833 66333 11828 11829 11830 11826 RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME%R-HSA-5659996.4 RPIA deficiency: failed conversion of R5P to RU5P 19895 DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.4 Defective GGT1 in aflatoxin detoxification causes GLUTH 14598 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.4 Signaling by TGF-beta Receptor Complex 16998 68010 17872 16456 320910 18762 65112 11848 20602 14479 102098 108075 20683 70737 16420 93742 211586 170749 56513 12402 56207 241226 21781 11545 66105 667035 97064 22190 20901 26413 18787 26417 20482 20481 19047 17869 16412 94093 17126 17127 17128 16416 66313 17131 21815 264064 328572 12843 56424 17283 22284 19045 103573 228839 16419 83814 18550 16477 21812 21813 19046 107951 93836 20185 67821 12579 22608 12454 18002 13559 104394 51813 19042 14225 12455 72949 16410 22192 21803 21814 21808 75788 433759 216080 19650 21809 268977 16997 MYD88 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 96%5602498 MyD88 deficiency (TLR2 4) 17087 117149 12491 21899 20193 12475 17874 14161 12229 434174 21898 24088 21897 20201 110135 20202 99571 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 96%2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 13388 16449 11487 54485 11491 16450 18128 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME%R-HSA-5619076.4 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) 216227 HYALURONAN METABOLISM%REACTOME DATABASE ID RELEASE 96%2142845 Hyaluronan metabolism 114332 15366 56398 15118 15117 15587 15116 192188 20544 235504 110006 77042 15586 80982 109685 12505 15212 15211 27416 74468 METABOLISM OF VITAMIN K%REACTOME%R-HSA-6806664.5 Metabolism of vitamin K 71707 69568 27973 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9028335 Activated NTRK2 signals through PI3K 18212 78405 18708 12064 14388 18706 GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 96%162658 Golgi Cisternae Pericentriolar Stack Reorganization 59021 12534 18817 56041 74498 66352 12442 26413 99412 76308 19324 70231 DRUG-MEDIATED INHIBITION OF CDK4 CDK6 ACTIVITY%REACTOME DATABASE ID RELEASE 96%9754119 Drug-mediated inhibition of CDK4 CDK6 activity 12444 12445 12571 12567 12443 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.5 KIT mutants bind TKIs 16590 ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.7 Adrenaline,noradrenaline inhibits insulin secretion 14702 14696 56808 12296 12297 14697 14678 14677 14710 14699 66066 14700 14688 14708 14706 14704 12289 14695 224129 11512 14693 64337 14709 14701 11551 11553 12288 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629597 Highly calcium permeable nicotinic acetylcholine receptors 11438 110834 110902 11435 11440 108015 108043 11444 110835 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 96%9637690 Response of Mtb to phagocytosis 18655 16211 672511 12721 70686 16646 15239 13806 19720 606496 233405 271457 667035 22190 13035 19349 18126 26413 26417 108664 71514 VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 96%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization 11739 433923 11740 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME DATABASE ID RELEASE 96%5619063 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) 71279 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN LYSOSOME BIOGENESIS AND AUTOPHAGY%REACTOME%R-HSA-9857377.3 Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy 114143 11964 11966 11886 100039636 66335 11973 11974 11972 108664 66290 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.5 Sema4D induced cell migration and growth-cone collapse 13866 67268 67938 17904 11848 11852 11853 17880 19877 77579 71960 20354 16885 16886 223881 69632 17886 19878 213498 235611 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.4 Signaling by cytosolic FGFR1 fusion mutants 14389 110279 20846 20851 20848 20850 75296 360013 432508 21848 67529 13047 18708 76007 18706 IFNG SIGNALING ACTIVATES MAPKS%REACTOME DATABASE ID RELEASE 96%9732724 IFNG signaling activates MAPKs 110157 16451 15980 15979 16452 26413 26417 15978 SOMITOGENESIS%REACTOME DATABASE ID RELEASE 96%9824272 Somitogenesis 56436 13388 17463 57296 20422 26445 12387 26446 19172 19173 19175 21389 19177 18128 16842 26443 26444 19170 84653 56184 66413 17293 13389 59029 67089 70247 13838 21762 22123 16848 19179 19181 19182 23996 19664 19184 26440 19166 19167 26441 26442 69077 66997 23997 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.2 Translesion synthesis by POLK 68275 106344 72151 68240 19891 19687 19718 69263 19714 71890 56210 667035 22190 27015 18538 RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.5 Retinoid cycle disease events 242864 77974 79235 14539 19659 12057 22139 19682 11304 19771 20897 19662 ERK MAPK TARGETS%REACTOME DATABASE ID RELEASE 96%198753 ERK MAPK targets 21770 20111 19094 73699 73086 110651 20112 13712 101568 235584 67603 19052 319520 72349 17260 19053 51792 26416 17258 23939 26413 26417 REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 96%2029482 Regulation of actin dynamics for phagocytic cup formation 17913 246256 17973 14131 17909 105855 242687 330319 76884 11308 22324 16885 17886 108100 12928 11461 101314 26413 26417 15519 22325 11350 12502 57257 140579 330662 11465 140580 20430 18479 15516 17918 76709 19353 73178 20963 12229 56443 80987 68089 67771 12631 11867 56378 66713 74117 245880 14083 18016 22376 215280 68524 50884 17925 83767 17882 14129 329165 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME DATABASE ID RELEASE 96%196849 Metabolism of water-soluble vitamins and cofactors 21452 13361 52466 14104 74450 68214 73095 71743 75735 68087 211347 67618 269614 106564 72621 66812 73132 18563 26464 22361 18605 18606 330064 209558 19300 20525 68421 238505 210009 14873 18113 78038 72039 17250 107476 100705 14276 22072 110821 66904 17850 109136 77697 109129 67096 100017 12182 108037 93835 59027 108156 17769 11433 216225 65969 319945 67375 52710 246703 225994 68591 107747 103711 29807 17434 74080 68646 20527 110948 78914 66473 69564 268566 105663 11761 230125 102570 223646 66454 54219 26363 100039707 192185 20509 69698 69372 69906 14725 214424 17768 328417 54391 116914 67287 80285 270685 52552 20425 109754 671535 67993 109672 547253 67795 54338 226518 20522 23959 216188 14603 216134 67283 665563 12494 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME DATABASE ID RELEASE 96%159230 Transport of the SLBP Dependant Mature mRNA 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 69912 13684 103468 20492 19386 234865 59015 69736 21681 110379 170762 108989 53319 231042 227699 223921 227720 445007 269113 66679 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME%R-HSA-6804115.2 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 12532 78893 69125 234594 18983 12795 22059 219103 52846 53621 231464 20620 72068 18148 12227 232791 104625 66214 58184 228140 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.4 Toxicity of botulinum toxin type D (botD) 64176 22317 64051 22318 75209 SIGNALING BY ALK IN CANCER%REACTOME DATABASE ID RELEASE 96%9700206 Signaling by ALK in cancer 16367 12575 78798 268980 13666 108147 215114 19645 12211 19043 21402 56438 19084 14025 16364 11682 12047 70297 16153 18148 17886 26965 667035 22190 26413 26417 327826 16573 13433 19386 22059 238037 14939 67533 14268 16154 14235 22160 18646 108989 54167 232679 18708 18709 81910 76850 239528 18706 22330 74769 672511 236511 17246 13191 26420 20850 54721 59069 18412 14784 16477 217351 214150 16593 17210 69162 15170 380928 17454 26419 116849 12608 27267 20846 20848 16476 667739 107971 67300 433759 18803 21787 17698 22637 67160 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.2 MET activates STAT3 20848 15234 17295 NUCLEOTIDE SALVAGE DEFECTS%REACTOME%R-HSA-9734207.3 Nucleotide salvage defects 15452 11486 11821 ADAPTIVE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%1280218 Adaptive Immune System 20437 99152 636931 668450 328234 76608 56208 19823 12387 227738 58194 74153 12550 22201 79263 22209 74244 53323 140629 20404 68497 70620 330369 23807 140499 59009 17237 50788 22213 67128 433766 22222 19271 224938 22214 17999 98766 67615 19155 268470 22436 67588 59026 107568 230903 109905 66772 208372 76454 70093 329152 117146 54401 65247 22215 65255 67345 81018 18176 84585 20662 217342 142687 15461 209462 110157 78910 231380 14161 65256 70392 215449 69807 244421 22036 224170 240396 225055 24105 218978 232539 110135 56515 99571 170823 215061 328572 67138 19822 17087 74132 67490 231670 672511 56444 226098 67665 19041 69754 22428 13191 224619 77113 14897 12344 59044 207952 59288 70348 320118 170737 70928 56228 30843 68854 76294 211007 21898 72323 399566 18024 30945 68098 100763 214931 19264 12914 640703 268373 19055 19056 19419 83433 18018 18019 240168 19058 14225 18021 22177 16476 24088 21897 110351 26934 66397 17969 56438 69608 15006 218811 99683 20619 240095 13058 667803 13057 17970 17972 14991 77371 20334 21899 22195 12526 50873 16396 56424 234779 14827 11771 11772 20963 71770 434174 12229 218203 17060 12518 15985 26554 232910 211255 11773 19260 18749 22376 22210 14129 269717 246256 109305 12567 12443 56371 27401 20866 229709 16331 73470 16438 16563 16439 18747 234663 117149 12491 20193 140792 16440 73699 26377 68097 19052 73804 19053 51792 226849 225849 26931 21770 26932 56455 229841 80898 107995 235661 110379 19294 18803 13427 14828 13426 217303 13424 228421 17533 192656 17874 12266 15898 22329 16421 65972 16414 78369 21679 15267 21676 319168 21678 319167 14281 224105 226144 547431 75778 238555 76850 237754 239528 195349 319186 12231 21677 319178 319183 319182 193670 54197 236511 319190 26754 12475 241113 14282 56717 70377 319176 69654 18034 216440 319181 19353 20014 213988 57261 103963 217351 56637 214150 69038 227743 13135 15894 19247 13819 14969 14968 66753 104709 67819 208154 14056 15170 116891 17454 20338 16569 319169 109270 50723 67075 105787 108079 20846 19079 54130 20848 108097 625328 78303 319188 15270 58205 16818 19082 80286 56716 624153 68292 23797 16430 382522 233833 53859 16451 21415 232440 13200 16570 13626 319149 72297 22628 320207 16478 16842 22612 11651 11652 12483 22324 15077 269523 66310 18710 140858 97064 18566 230979 52615 26410 19646 213464 14360 12988 11910 16568 214162 13001 13000 100039026 17869 245688 20747 12500 22601 12501 12502 15251 17096 23808 67731 12504 18109 244373 18005 17444 78757 228775 53598 60533 76580 108099 16362 30955 18708 18709 18479 12477 18706 18607 74769 18707 13038 66357 12487 12519 380711 12524 13039 20469 21414 21416 231051 18481 12702 16594 668303 16579 232943 13036 13034 19348 229445 56464 71819 226977 16593 16551 110033 280408 16149 209737 20201 74764 20202 15002 15001 64291 16768 15000 14998 67923 106052 242960 20343 30838 13052 83490 77647 270152 58217 30050 50762 15896 170786 22319 50754 19211 19349 232801 30925 217304 26904 14130 217306 16572 100043861 213980 16573 16641 16643 16412 232790 68628 71326 50928 52685 75345 21947 57781 17086 50789 231805 170741 84544 30839 243958 243864 54215 75863 629970 100038830 52855 328833 83382 246746 20612 319352 27007 54698 18146 12480 20400 12525 225825 224840 17470 140497 23900 94212 16419 57743 17534 21354 21356 13033 21355 93836 53421 20909 100043039 246278 66212 12343 12345 12340 16571 16410 67300 13429 12757 71745 14026 74947 17973 12317 20743 103967 66105 22323 12330 80751 19025 66313 12143 22320 11840 13430 21762 22123 12675 108723 19179 19181 19182 23996 19184 75788 18033 26440 19166 18035 19167 18036 26441 18037 16822 26442 75669 22637 69077 16797 66997 630146 23997 23880 12234 16428 56436 17463 57296 20422 26445 26446 225326 19172 19173 19175 19697 19177 21402 16150 26443 26444 16151 19170 19696 22063 12042 66413 26965 667035 22190 18751 240354 59029 26409 67089 103583 70247 117589 78541 69299 218215 16408 94090 233902 69116 208650 73998 50760 20821 235320 242521 209239 74492 75234 66799 16401 72194 67845 15204 69706 235439 13040 15007 57751 19141 12010 140630 56508 11768 94091 13030 223864 11769 217194 12478 108012 16924 12520 11764 22019 226541 11765 65257 11767 104184 252903 19820 78913 242785 56791 68729 16912 69010 19171 211949 66743 233040 231672 18744 50492 224826 231863 101358 12449 224023 16913 109161 83814 22193 71538 19186 76375 19188 67455 100041766 14794 216150 217217 71999 93765 269529 66589 83962 18761 230654 22034 635668 19395 240028 66515 269514 68652 78889 69162 68431 230904 28105 71865 380928 20333 50868 207215 22200 627648 22631 207304 75717 70294 13032 67921 100041484 22192 66663 217232 142688 56317 243574 59008 321006 268291 66156 209200 216080 74646 69957 448987 17222 22346 56736 68612 228003 52563 12703 22194 212919 71393 68999 54484 52206 20439 100039535 218793 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 96%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 12571 12567 12578 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.3 Biosynthesis of DPA-derived SPMs 11684 11687 19225 11689 PHOSPHO-PLA2 PATHWAY%REACTOME%R-HSA-111995.3 phospho-PLA2 pathway 18783 26413 DEFECTIVE HEXA CAUSES GM2-GANGLIOSIDOSIS 1%REACTOME%R-HSA-3656234.4 Defective HEXA causes GM2-gangliosidosis 1 15211 SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674401.2 Sunitinib-resistant PDGFR mutants 18595 TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME%R-HSA-6791462.4 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P 21351 CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 96%373076 Class A 1 (Rhodopsin-like receptors) 17202 17201 22094 12640 140498 212108 19773 242093 381489 239336 16336 23919 14419 12772 12774 12768 80901 14747 84112 20607 59289 12776 12775 12458 12773 12771 170458 18386 18389 14539 23925 19214 243270 239283 19222 14427 19217 18166 19218 19219 18167 18168 14294 12802 14293 12801 14309 21390 12765 227288 14308 56838 57811 17773 244701 19156 20605 19065 11550 20606 19064 11548 211578 11549 80885 272031 12145 20609 20608 14428 13051 227289 75769 217212 208990 216152 22439 11820 20132 140795 57349 17171 30878 623503 107522 17329 20290 11554 17200 11555 18155 11556 55985 15560 20303 109648 15559 20304 12057 15558 20306 213788 20296 15557 20292 13492 20302 382348 57385 13491 20295 13490 20297 13489 100039973 13488 74191 111174 100038965 215855 20299 503558 13610 215854 56066 12672 20311 12671 20312 15552 20300 15466 11539 15551 11540 15550 18610 243764 18619 12669 229791 15465 235044 99296 11542 18241 252837 209512 66102 15566 13611 15565 22095 15563 330122 15562 225192 94226 20310 14825 353344 14429 14764 13603 11609 23796 12777 226278 12766 226304 321019 12778 381073 110168 75805 436440 76854 12769 64095 15199 230857 14763 54199 70839 12267 171469 16866 16867 227326 14739 12854 13609 13349 16952 15945 70086 20315 11541 58861 12767 53978 22044 22045 57260 233571 235036 13617 30044 14715 14714 13615 18441 246691 18442 14745 16963 16995 208188 229214 56183 56696 58182 19204 104443 224065 19216 19220 319239 14289 238377 14744 225642 56744 14829 67168 21333 11606 11607 12061 12062 216749 21338 14064 20293 65086 14063 14062 14061 21337 23832 319197 21334 21336 12424 12425 12426 217369 227717 14065 381810 107221 280287 24111 574402 78134 100043254 237362 385643 433292 246313 233079 233080 233081 50501 67405 18216 54615 12209 78826 114229 15171 110312 18217 387285 230777 11551 14767 11552 68039 11553 18101 18429 11998 18430 54140 26361 12000 18387 18390 212541 20210 15139 12266 319430 12273 20604 207911 13616 13614 18976 17199 13618 17203 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.11 ROS and RNS production in phagocytes 18127 17969 18173 13058 76113 13057 242341 68775 18126 17970 17523 19354 76252 17972 11972 108664 66290 11964 110935 18125 11966 100039636 66335 11973 11974 74915 338375 21871 73834 114143 66237 11975 74096 27060 140494 66144 SARS-COV-2 MODULATES HOST TRANSLATION MACHINERY%REACTOME%R-HSA-9754678.3 SARS-CoV-2 modulates host translation machinery 16785 57294 107686 384091 666609 216766 621705 20595 66603 53975 276919 20641 667035 20638 69731 432803 67332 27207 67097 670832 100039316 633683 20044 27050 667279 20085 668144 20084 382492 20055 75617 20115 27370 629957 76846 20102 100040298 20103 668668 667739 66481 225058 100038875 267019 67941 PHOSPHORYLATION OF CLOCK, ACETYLATION OF BMAL1 (ARNTL) AT TARGET GENE PROMOTERS%REACTOME%R-HSA-9931512.1 Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters 12914 214162 12753 11865 EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 96%3928664 Ephrin signaling 54126 13848 13846 13845 270190 216963 18481 13643 13642 13641 19353 53378 13844 17974 224105 18479 14360 KERATAN SULFATE DEGRADATION%REACTOME%R-HSA-2022857.7 Keratan sulfate degradation 18295 16545 244757 116847 17022 75612 50917 14264 70893 15212 15211 27047 12091 MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 96%9022927 MECP2 regulates transcription of genes involved in GABA signaling 14415 14417 DEFECTIVE CUBN CAUSES MGA1%REACTOME DATABASE ID RELEASE 96%3359463 Defective CUBN causes MGA1 93835 14603 65969 TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME%R-HSA-8878159.4 Transcriptional regulation by RUNX3 56436 20750 17463 16449 57296 21415 20422 26445 12387 26446 12575 11906 19172 19173 19175 19177 20779 18128 16842 26443 12443 26444 270118 19170 66413 667035 97064 22190 59029 67089 14219 70247 16408 17869 22601 22059 17127 208727 17128 16401 21679 66313 21676 21678 103806 14312 21677 328572 12400 21414 17246 21416 333639 12399 12578 12914 14534 18519 21762 22123 15205 19179 19181 21803 19182 23996 56484 19664 19184 75788 26440 16653 19166 19167 26441 26442 69077 12125 66997 23997 FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190239 FGFR3 ligand binding and activation 14172 80857 14425 14180 80903 64654 14175 14173 14164 ARACHIDONATE METABOLISM%REACTOME%R-HSA-2142753.8 Arachidonate metabolism 67103 13479 320997 245533 13120 11690 631304 11687 13118 72054 17250 208285 21391 19223 13124 19225 11689 13850 18783 17164 54486 16993 15446 17001 11686 23801 14775 625249 72303 107141 13077 19215 13076 13110 71519 106648 105349 14776 96979 100040843 13078 19224 11684 77219 12408 14073 18979 100043508 330260 269823 14598 11688 319446 64292 23887 66469 26457 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 96%1250196 SHC1 events in ERBB2 signaling 13866 13649 18753 18183 83961 100042150 12223 18176 20662 13874 15461 15200 211323 19248 13645 18754 18750 20416 MAPLE SYRUP URINE DISEASE%REACTOME%R-HSA-9865114.1 Maple Syrup Urine Disease 12040 243382 13171 13382 12039 PAOS OXIDISE POLYAMINES TO AMINES%REACTOME DATABASE ID RELEASE 96%141334 PAOs oxidise polyamines to amines 212503 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME DATABASE ID RELEASE 96%5579014 Defective CYP27B1 causes VDDR1A 13115 SIGNALING BY EGFRVIII IN CANCER%REACTOME DATABASE ID RELEASE 96%5637812 Signaling by EGFRvIII in Cancer 12539 13649 12402 18176 14388 20662 15461 18803 13645 18708 18706 20416 15519 MRNA CAPPING%REACTOME%R-HSA-72086.5 mRNA Capping 68092 433702 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.5 Metal ion SLC transporters 94249 76376 226999 236794 67547 331004 77031 236727 109552 105243 277973 110895 226781 20544 18173 338365 22784 170756 230810 18174 214111 53945 110891 106957 22782 98396 238384 213053 214922 640703 20541 227059 72027 106947 69048 110893 20529 15203 317750 12870 30791 14977 239436 72002 PECAM1 INTERACTIONS%REACTOME DATABASE ID RELEASE 96%210990 PECAM1 interactions 16416 15170 18613 18803 16818 19247 16331 17096 14360 22612 16410 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME%R-HSA-76066.4 RNA Polymerase III Transcription Initiation From Type 2 Promoter 21374 67065 71752 74414 233863 66420 72308 69833 78929 245841 544971 70239 269252 26939 67486 70408 20018 69870 70428 67371 17749 218832 100043714 67005 20016 98488 12909 G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME%R-HSA-8964315.2 G beta:gamma signalling through BTK 14708 14706 14702 14704 14696 14695 14693 64337 14709 14697 14701 12229 14710 14699 66066 14700 14688 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020591 Interleukin-12 signaling 16451 66902 18453 68981 54721 16153 19188 56044 11840 12631 20955 50926 667310 66162 18569 12798 18738 268373 11632 20849 12340 18826 53379 17319 18788 12306 16162 98758 16161 16160 15526 16159 20656 21351 14873 215449 21454 16906 667618 224105 17698 12346 16452 15978 SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME%R-HSA-433137.3 Sodium-coupled sulphate, di- and tri-carboxylate transporters 55961 243755 MITOCHONDRIAL PROTEIN DEGRADATION%REACTOME DATABASE ID RELEASE 96%9837999 Mitochondrial protein degradation 18293 636544 17991 66885 381760 14194 66948 69597 20917 66865 20845 13171 13382 68514 22272 624814 27377 17708 18747 17709 66494 69029 67003 234847 66904 15510 51798 171210 227197 67184 230075 64704 74142 14661 11655 14151 71147 56454 108037 21780 53895 64657 270166 433923 11740 69076 72535 17721 17722 17716 11669 17717 52815 56322 433806 15108 74143 227112 107029 99138 68646 13177 17995 67013 15107 11957 12858 78330 30059 68263 228026 11947 12857 75398 11949 11429 56282 67041 17705 67834 11946 269951 15526 110446 18597 15360 30056 71911 432676 381314 118451 11847 12974 226153 17448 SIGNALLING TO ERK5%REACTOME DATABASE ID RELEASE 96%198765 Signalling to ERK5 23938 23939 CELL CYCLE%REACTOME%R-HSA-1640170.5 Cell Cycle 52717 99152 56299 668450 29870 17187 12534 217653 20892 233532 100038822 70645 66311 70620 66578 26416 26413 240087 12545 59046 244329 59021 382030 67121 19094 56205 21664 52432 76044 78658 54401 71175 74549 66352 67181 52683 70231 16452 15516 328572 109145 17216 272551 17215 17217 17218 17219 103573 17220 78833 12544 69270 16906 22627 63955 22390 99412 72568 77805 12530 231506 12531 629959 54124 12532 20459 75660 23834 71988 208084 72171 214987 214901 20174 68964 72107 108689 56438 69535 18969 18968 19075 19076 66371 68953 93762 75608 14235 208092 66700 19088 223697 105513 12575 22589 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 21973 56371 27401 13163 16881 12448 12577 12576 108911 73470 16563 75786 18747 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 59125 218914 59126 12235 217718 67037 20842 68097 16319 213389 19052 28113 73804 19053 101185 51792 20877 381318 24061 52696 26886 66934 18221 445007 19357 226849 225849 17248 72155 26931 21770 26932 70385 12428 57294 17246 56455 226747 17120 26951 100710 57321 108000 229841 12237 12617 107995 72415 83815 12615 66570 319152 244495 208628 76707 21749 67139 497652 68014 21750 83431 13589 100043858 67849 12580 69912 625534 12579 13006 12578 18472 67733 103468 66468 76464 66442 67629 235661 56430 12427 234865 56150 12442 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 71521 13426 52504 17931 13424 228421 20843 17350 15366 66420 69833 67710 245841 69920 20022 20020 231329 20021 69241 66671 17749 100043714 17420 12572 15267 319168 319167 100986 15512 319186 319178 29813 319183 59092 319182 26374 50883 228829 319190 230376 319176 69654 71648 17274 319181 75296 56637 219072 225659 76478 22367 71955 78177 64383 224640 319169 319965 105988 28135 50850 214444 100042651 76816 54130 625328 56739 78303 140557 319188 50878 15270 20962 381644 74075 320558 64009 319565 71846 18750 624153 66654 20957 23797 75459 77053 382522 20873 68121 232440 78887 78798 319149 22628 225745 231123 11651 11652 15077 74360 238799 18536 66296 214552 21752 19646 18541 116733 13001 13000 100039026 17869 245688 71909 237222 94244 55948 30939 17096 17997 13548 22171 21877 13361 18005 73738 68475 53598 208518 100088 236266 12009 99100 103733 22154 98386 74470 104318 101565 16328 259279 14211 83922 171567 51885 68298 19348 215387 26370 76789 72083 71819 70099 101706 233276 103768 74237 22147 22151 19650 19651 17865 27373 22143 93687 208583 268930 53857 22152 227613 72119 22153 18148 216853 22142 22146 67951 100039786 73710 13726 22145 22059 71782 545486 238463 170762 108989 231042 227699 223921 227720 380664 269113 66679 18141 23825 107939 69482 71805 16475 54563 19069 70699 67141 72787 64899 18226 218210 50793 18392 72590 18393 30949 66634 14245 77011 26428 19046 72486 26429 12537 56452 77744 64898 71978 20135 15519 11350 16211 19384 219103 229776 56505 50496 13559 104394 21762 22123 19179 19181 19182 67956 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 27214 17463 67177 57296 20422 26445 14156 245474 26446 57441 19172 70024 19173 19175 19177 21402 26443 66181 26444 19170 66413 26965 68147 667035 22190 18751 52530 59029 107823 13404 67089 68251 26972 103583 20184 19183 70247 217716 269582 76915 55993 70681 17687 70238 27223 12795 107976 210766 59004 22196 15204 671392 19360 69745 17535 21975 27354 12021 60530 81601 327762 269400 59001 19361 114714 22427 19687 19718 69263 231863 15574 11920 66979 12189 12190 235610 231724 237911 19355 225182 93765 26909 18538 235559 19324 12144 105522 381306 68275 106344 72151 18971 68240 67857 18972 19891 18973 18974 74498 22631 19367 52036 19356 22629 67967 20878 12649 217232 56317 59008 18817 66156 433759 216080 56041 69957 448987 17222 75430 68612 52563 22194 76308 68999 52206 100039535 DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME%R-HSA-5619098.4 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) 20526 LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 96%162599 Late Phase of HIV Life Cycle 18108 107305 72543 194309 52348 116733 73711 22088 67123 330192 76959 66201 19386 20479 66914 19384 100088 19385 18107 445007 270627 68092 228980 319944 21374 103573 433702 20922 20833 216185 108143 18550 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 69912 21343 209361 226182 12454 229906 103468 235459 24074 268373 83602 58202 68153 74197 67923 234865 27224 27632 24116 12455 72949 59015 13716 69736 63856 110379 68705 98053 667035 13871 22190 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 66371 14884 68953 75608 18571 170762 108989 231042 227699 208092 223921 227720 66700 269113 66679 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 83814 105513 IPS TRANSPORT BETWEEN NUCLEUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 96%1855170 IPs transport between nucleus and cytosol 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 OADH COMPLEX SYNTHESIZES GLUTARYL-COA FROM 2-OA%REACTOME DATABASE ID RELEASE 96%9858328 OADH complex synthesizes glutaryl-CoA from 2-OA 78920 13382 209692 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 96%69273 Cyclin A B1 B2 associated events during G2 M transition 12532 12534 12428 217653 268930 100038822 103573 12566 72415 72590 30949 77011 56371 72486 77744 66671 12427 17420 73699 12572 12442 71978 19052 19053 18817 51792 14235 22390 12530 12531 RHOT1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013425 RHOT1 GTPase cycle 59040 67095 70827 229877 POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME%R-HSA-8957275.2 Post-translational protein phosphorylation 94111 20750 13406 30060 15464 11704 19089 71421 217847 77583 105348 80752 16852 18220 11816 15160 66853 20856 381677 66848 338366 83554 11576 12558 66557 98170 17182 14314 16425 232146 12155 76453 74761 15529 100037258 14161 71853 29817 99571 22393 12159 216197 11806 238055 16193 385643 14734 19123 12870 22041 11820 14456 11487 64654 11905 13010 17304 18619 56453 12266 625018 16777 21923 16779 226519 14268 16709 14118 382014 22027 12321 100102 17283 20255 18453 16009 16006 66113 104009 11657 20703 11625 11807 14067 21857 269181 66940 208659 13003 13602 16007 75396 16011 16010 246228 12977 13801 11804 12653 11698 20254 56047 268977 19672 FATTY ACID METABOLISM%REACTOME%R-HSA-8978868.7 Fatty acid metabolism 13479 16922 12908 68801 17117 67528 21835 74114 110959 14081 56185 80911 13850 111175 93732 97212 20280 11363 231086 171210 17164 56794 108099 54486 16993 15446 11686 23801 14775 625249 14104 72303 107141 13077 19215 13076 70316 13110 14776 96979 20524 11409 93747 12896 15107 12895 20216 68041 18559 19224 66198 264895 56473 77219 76267 12408 14073 66834 18979 57279 330260 74147 269823 171282 70025 11666 26458 71985 15488 52538 113868 72482 170789 11688 26378 78245 64292 102632 66469 26457 56360 171281 67103 74156 320997 245533 13120 13167 11690 223722 631304 329910 11687 13118 72054 17250 208285 74159 21391 19223 13124 20249 67131 170439 107476 19225 11689 20181 110821 66904 17850 73724 109136 18783 12894 75778 17001 19063 257633 433256 83603 74522 54397 50790 15487 328845 74205 57874 71519 14979 106648 30963 105349 104112 100040843 11370 106529 13078 54325 20520 66775 94180 74121 12686 216739 11364 74559 67460 234309 13177 243078 70757 56348 99035 26568 54326 11684 100043508 26922 108079 108097 14598 19015 319446 23887 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702620 quizartinib-resistant FLT3 mutants 14255 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME%R-HSA-3560783.4 Defective B4GALT7 causes EDS, progeroid type 15529 11603 23888 20971 12111 121021 13004 20969 15530 14734 103978 71951 29873 20970 13003 218271 14735 14733 12032 13179 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME%R-HSA-176408.6 Regulation of APC C activators between G1 S and early anaphase 12234 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19177 21402 26443 26444 12566 19170 66413 26965 56371 667035 22190 59029 67089 70247 12428 12237 67141 107995 12427 56150 21762 22123 19179 19181 19182 217232 23996 56317 12236 19184 59008 18817 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 TAK1-DEPENDENT IKK AND NF-KAPPA-B ACTIVATION%REACTOME DATABASE ID RELEASE 96%445989 TAK1-dependent IKK and NF-kappa-B activation 22030 19697 16150 18034 16151 192656 16179 434174 71481 667035 211550 22190 66513 93765 20203 66589 26409 20210 24110 22034 257632 66724 68652 80750 223664 107607 69721 270151 11596 67454 22059 71966 12675 108960 59025 18033 18035 18036 11820 12370 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 96%8964572 Lipid particle organization 243168 14311 69573 12683 68680 228859 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME DATABASE ID RELEASE 96%399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity 53623 14799 17246 243547 14802 238276 18693 11771 12322 12323 108058 12325 18751 14800 54377 21912 13385 74053 18195 13383 12300 54376 18752 81905 17920 18750 REGULATION OF NPAS4 GENE EXPRESSION%REACTOME%R-HSA-9768759.2 Regulation of NPAS4 gene expression 233833 20807 19712 236511 17454 225872 14815 56461 213988 217351 214150 76850 239528 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 96%5676934 Protein repair 22166 320183 27361 76467 110265 18537 G2 M DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69473.7 G2 M DNA damage checkpoint 12532 12534 22628 70620 107823 68251 20184 240087 70681 70238 100039786 27223 107976 210766 54401 55948 22059 59004 15204 19360 17535 21975 319186 27354 12021 319178 319183 319182 81601 50883 327762 12428 319190 22427 19718 69263 15574 319181 11920 12189 235610 319152 231724 237911 19355 225182 93765 26909 235559 12144 68275 106344 72151 68240 19891 12427 22631 19367 22629 19356 12649 78303 319188 15270 22627 22390 382522 DEFECTIVE CBLIF CAUSES IFD%REACTOME DATABASE ID RELEASE 96%3359457 Defective CBLIF causes IFD 14603 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME%R-HSA-69166.4 Removal of the Flap Intermediate 68275 18969 18968 18971 327762 68240 18972 14156 19075 19076 19891 67967 69745 18538 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%9623433 LXRs regulate gene expression to control bile acid homeostasis 22260 20181 20602 20182 22236 17977 16204 20185 22259 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 96%380259 Loss of Nlp from mitotic centrosomes 20873 68121 12534 78887 22628 225745 231123 227613 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 83922 75296 26370 76707 219072 13589 225659 18472 76478 78177 28135 214444 76816 54130 18817 381644 13427 22627 13424 27373 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 96%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors 22632 13866 70472 13982 16590 12640 13649 22339 21802 21420 21419 21418 MATURATION OF NUCLEOPROTEIN%REACTOME%R-HSA-9694631.7 Maturation of nucleoprotein 93687 15469 22196 20817 214424 20815 328417 606496 67287 80285 52552 56637 671535 547253 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.6 Transport of nucleotide sugars 108652 22232 229782 228368 58246 24060 242585 70484 73836 CREB3 FACTORS ACTIVATE GENES%REACTOME%R-HSA-8874211.3 CREB3 factors activate genes 75766 78284 270669 12913 77128 26427 208647 208677 56453 PROCESSING OF SMDT1%REACTOME DATABASE ID RELEASE 96%8949664 Processing of SMDT1 78506 215999 69029 234847 73078 69597 66865 381038 66815 68115 68514 12034 66592 18673 27377 216001 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME%R-HSA-212718.4 EGFR interacts with phospholipase C-gamma 15200 18803 11839 13649 21802 13645 12223 71920 13874 PYROPTOSIS%REACTOME%R-HSA-5620971.6 Pyroptosis 670717 16173 16363 69146 22059 66371 12018 14939 50701 22061 68953 12367 16176 105513 75608 16175 12362 12028 54722 434174 12363 16362 208092 66700 BIOLOGICAL OXIDATIONS%REACTOME%R-HSA-211859.4 Biological oxidations 13479 17161 109731 110198 71522 207182 71670 56615 211666 66447 13075 244209 70484 69574 68021 11670 76263 22017 13849 20186 14863 237940 13123 104086 11754 13122 67758 107146 216558 109857 233799 233801 212503 18105 272428 435528 67247 66112 69065 75475 13885 14872 54486 17961 68252 94215 66054 72094 15516 14862 213012 14630 14865 394436 14866 394433 68312 22235 100042314 71773 14874 13087 100727 13116 14871 13107 436059 100559 14261 13115 68044 13106 231396 110115 68214 622127 394434 56050 11624 94284 18984 11622 552899 72303 223337 107141 17977 242585 13088 17960 13077 56448 13076 13114 74134 17978 72082 13110 13113 545817 14859 13070 14629 19224 66427 67768 108645 57344 67883 67674 238505 11720 109652 232087 210009 14873 14854 269378 18113 12846 320997 76507 13120 631304 13118 72054 208285 64385 21391 19223 13124 22021 13121 22022 55990 14262 117147 20181 104158 11668 102294 68165 14149 14148 58810 13082 13081 13072 60525 13079 72535 232174 11529 68738 546726 11522 26876 71519 11532 106648 11669 13909 100040843 13078 11863 11864 76491 11632 56362 319655 20859 242291 100043508 20860 23827 73671 29859 20887 18976 14598 319446 109754 22236 23887 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME%R-HSA-6799990.3 Metal sequestration by antimicrobial proteins 17002 16819 20201 20202 HCN CHANNELS%REACTOME DATABASE ID RELEASE 96%1296061 HCN channels 15165 15168 330953 15166 RAS GTPASE CYCLE MUTANTS%REACTOME%R-HSA-9649913.5 RAS GTPase cycle mutants 15461 16653 18176 PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-HSA-418360.3 Platelet calcium homeostasis 269717 11937 11938 53313 109305 109552 67972 11941 320707 381290 22065 22068 20866 110891 16438 16439 18438 640703 20541 110893 26946 16440 18436 228139 18440 94045 231602 18439 SIGNALING BY CSF3 (G-CSF)%REACTOME DATABASE ID RELEASE 96%9674555 Signaling by CSF3 (G-CSF) 14389 16451 19823 12702 20851 20850 54721 20963 14784 66105 667035 100041766 22190 19247 20416 12986 67923 75717 17096 20846 20848 12985 16653 216080 15162 12703 16452 SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.8 Signaling by Receptor Tyrosine Kinases 12388 12387 15901 58194 20408 12402 56324 20779 15239 20404 17295 12389 20844 20405 13858 107746 14786 109880 12929 208994 26416 12928 19271 56044 64143 18754 18049 17999 216148 26413 26417 29857 20416 67588 327826 22325 107568 18211 109905 77480 19094 20418 102626 15925 19730 54401 116701 26415 26395 26396 57257 19762 18176 20662 19877 19769 15461 16416 17164 215449 19878 16480 16452 328572 12539 17395 13367 18552 18550 17260 18553 17261 242341 68775 15183 20185 76252 11972 108664 66290 54126 11909 640703 11964 110935 11966 100039636 66335 11973 11974 74915 15234 338375 21871 73834 14181 114143 72514 66237 11975 16542 54411 27060 12569 12568 50884 140494 83767 329165 66144 20459 105855 242687 19205 17969 76936 11308 13058 13057 108100 17970 101314 17972 12830 13433 11516 13385 12829 12828 15382 11517 12827 18595 12826 59013 19164 98758 19165 12841 100042305 208117 12840 59287 100039623 245026 12839 140580 16396 12835 12834 12833 12385 56424 16453 11771 11772 12028 71770 232910 11773 245880 114715 19342 114716 218397 18749 319939 217169 67299 76884 16186 19253 14255 229709 16438 16439 18747 19255 15507 16440 73699 110651 20112 19052 19053 51792 20732 15451 15235 19882 20733 21770 15904 211323 14402 14401 14400 23939 14394 14407 12064 14406 14812 14388 21844 18212 208869 57249 18205 107971 78405 18803 11839 13645 26362 19283 11487 11491 12562 17005 51789 68705 98053 66420 69833 67710 17258 245841 20203 69920 20022 20020 231329 20021 69241 17749 100043714 620393 100040260 19242 101568 235584 67603 319520 72349 14281 224105 13654 75778 14282 56717 13653 19353 14256 227743 19247 15170 109270 20846 20848 19341 17242 14257 16818 260302 56716 18750 23797 21990 56437 14066 17095 12570 15902 23938 17172 54152 18183 15903 83961 14283 100042150 211770 16478 76890 17936 17937 22612 11838 11651 11682 13656 11652 13655 22324 381677 19303 18710 18791 14360 54607 12988 16370 16002 16000 17869 13649 21802 22601 15251 17096 14580 18109 17444 78757 228775 17122 21825 60533 231821 18708 71785 18709 18479 21827 16765 18706 21828 18607 214425 74769 12991 18127 27371 230126 18481 24064 68092 17346 54426 433702 16477 80707 58202 16001 18596 18213 21682 18762 16923 11848 17228 19273 71520 14159 14158 23921 73086 107932 11540 74334 19712 16412 140579 330662 19246 20698 20430 59079 24063 19272 16206 239463 94212 20851 20850 14784 19248 13033 13866 14425 16410 14083 21814 21826 67903 17974 224116 18187 67300 20315 13429 12757 20750 17973 20393 18186 84092 11816 71436 103967 15519 56705 399558 396184 19268 19280 12223 71920 13874 13712 15200 19229 14254 13430 80903 384783 75669 14186 14165 81897 14389 16367 14172 80857 18576 14170 16334 225326 14180 14178 14177 67112 64654 14175 14174 14173 14164 83379 16398 667035 16400 22190 18751 18654 21406 13982 19277 18753 16775 16776 16777 16779 16780 226519 16782 16772 23928 11489 16773 16774 18667 227290 18591 20807 14783 16337 12927 20852 13854 12142 68652 11845 14205 20111 13859 75717 18815 20466 12649 17179 20692 433759 16590 22341 93686 22339 77411 22340 21843 21841 12703 15182 SIGNALING BY MET%REACTOME%R-HSA-6806834.4 Signaling by MET 58194 20408 12402 56324 20779 84092 15239 20404 17295 20844 20405 13858 107746 16398 12929 16400 667035 22190 12928 19271 74334 19255 56705 109905 16412 16775 16776 16777 16779 18176 16780 20662 226519 15461 16782 16772 23928 16773 16774 215449 19246 18708 20732 15451 18706 20733 16206 54426 19353 19247 11845 19342 14388 15234 14083 20848 19341 224116 260302 319939 217169 67299 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 96%9028731 Activated NTRK2 signals through FRS2 and FRS3 18212 327826 15461 107971 78405 19247 12064 18176 20662 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME%R-HSA-9609523.4 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 56389 83762 15368 71446 13726 224727 56495 30960 28146 67604 27643 19122 22318 20907 11820 12328 52551 100043039 66212 POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174411.6 Polymerase switching on the C-strand of the telomere 214987 214901 68964 72107 108689 19687 57321 69535 19718 69263 21749 497652 21750 18538 18969 106344 18968 72151 18971 18972 19075 19076 67967 28113 101185 69745 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.6 Ubiquitin-dependent degradation of Cyclin D 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 12567 26443 12443 26444 19170 66413 56637 667035 22190 59029 67089 70247 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO STRA6 LOSS OF FUNCTION%REACTOME%R-HSA-9918449.1 Defective visual phototransduction due to STRA6 loss of function 22139 20897 19662 DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 96%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) 103988 ISOVALERIC ACIDEMIA%REACTOME DATABASE ID RELEASE 96%9914355 Isovaleric acidemia 56357 RESPIRATORY SYNCYTIAL VIRUS GENOME TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9828642 Respiratory syncytial virus genome transcription 15481 TRKA ACTIVATION BY NGF%REACTOME DATABASE ID RELEASE 96%187042 TRKA activation by NGF 18211 18049 DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.2 Defective F8 sulfation at Y1699 22021 14069 22022 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.2 Reversible hydration of carbon dioxide 71934 12350 12352 230099 12353 12354 56078 76459 23831 12346 12349 12351 3-METHYLCROTONYL-COA CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9909438 3-Methylcrotonyl-CoA carboxylase deficiency 78038 72039 METHYLATION OF MESEH FOR EXCRETION%REACTOME DATABASE ID RELEASE 96%2408552 Methylation of MeSeH for excretion 21743 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME%R-HSA-2466712.4 Biosynthesis of A2E, implicated in retinal degradation 242864 DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME%R-HSA-5656364.4 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) 20537 DRUG ADME%REACTOME DATABASE ID RELEASE 96%9748784 Drug ADME 17250 71522 207182 22324 12780 15484 15483 12401 18102 76952 18103 229363 27416 239273 114304 16434 22436 22325 104158 214254 13340 269346 15452 22017 63959 100042069 14863 23917 14923 77337 57257 107146 233799 12038 233801 272428 435528 17961 94215 72094 66054 394436 76408 394433 71773 100727 100559 14871 436059 231396 13106 394434 94284 552899 223337 72303 107141 17960 56448 13114 19353 20518 20517 20519 18671 11657 19879 28250 75894 18950 26357 20501 11534 11486 12215 20859 18979 20860 28253 269823 71279 20887 109652 14598 22236 23887 18534 RUNX3 REGULATES WNT SIGNALING%REACTOME%R-HSA-8951430.3 RUNX3 regulates WNT signaling 21415 17869 12387 21414 21416 12399 16842 12443 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.5 Loss of Function of SMAD2 3 in Cancer 21803 21812 21813 17126 17127 17128 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME DATABASE ID RELEASE 96%9603381 Activated NTRK3 signals through PI3K 16367 18213 18205 18708 20779 18706 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.3 Type I hemidesmosome assembly 16782 12821 192897 18810 16774 16403 12476 16780 CLEARANCE OF SERATONIN%REACTOME DATABASE ID RELEASE 96%380615 Clearance of seratonin 17161 11669 15567 CARNITINE SHUTTLE%REACTOME%R-HSA-200425.10 Carnitine shuttle 12896 20181 12895 108097 68041 19015 21835 12894 108099 20520 57279 108079 NUCLEOTIDE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%8956320 Nucleotide biosynthesis 67054 14450 100042069 108147 23917 69719 11564 11566 231327 237823 22247 229363 11565 56749 RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6793080 rRNA modification in the mitochondrion 72181 75619 227682 83485 94254 224481 66410 67390 217038 69821 71989 101122 68017 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME%R-HSA-5619108.3 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) 26569 SIGNALING BY FGFR2%REACTOME%R-HSA-5654738.4 Signaling by FGFR2 14172 80857 19205 14180 14178 12402 14177 76936 67112 64654 14175 14174 14173 14164 109880 68705 98053 667035 22190 66420 69833 67710 245841 69920 26413 20022 26417 327826 20020 231329 20021 69241 17749 100043714 15382 18176 59013 20662 98758 15461 19052 19053 51792 18708 18706 68092 24064 17346 433702 19247 14388 14181 107971 72514 18803 93686 77411 80903 21843 21841 14165 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 96%419408 Lysosphingolipid and LPA receptors 13611 14745 94226 65086 272031 14739 53978 75769 13610 13609 216152 381810 229791 235044 ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME DATABASE ID RELEASE 96%162791 Attachment of GPI anchor to uPAR 241062 329777 228812 78928 276846 14731 18793 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME DATABASE ID RELEASE 96%5387390 Hh mutants abrogate ligand secretion 56436 17463 57296 20422 26445 26446 19172 19173 19175 226861 19177 26443 216440 26444 19170 269523 66413 667035 22190 59029 67089 70247 66753 16147 116891 20338 74126 21762 22123 20423 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 13363 66997 23997 TRIF (TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 96%937061 TRIF (TICAM1)-mediated TLR4 signaling 66105 71481 26416 211550 26410 26413 26417 19094 102626 73699 26395 110651 20112 17164 19052 19053 51792 17087 21770 26399 26400 26398 26420 13712 26414 26397 17260 21898 23939 11909 26419 12675 16476 18033 18035 18036 11820 12234 56480 54131 19697 21402 73086 16150 16151 192656 16179 26965 667035 22190 17258 20203 26409 20210 24110 103583 257632 80750 223664 107607 69721 231130 270151 11596 22059 67454 71966 108960 59025 100040260 101568 235584 67603 319520 72349 14281 12370 19766 11797 56532 22030 12475 22031 56489 225471 11796 106759 21353 18034 71648 54123 434174 100041766 14082 66513 93765 66589 19247 22034 66724 68652 20111 216080 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME DATABASE ID RELEASE 96%163210 Formation of ATP by chemiosmotic coupling 66477 11958 11957 11947 11949 68055 17705 11946 66043 11950 100041835 100039108 432676 228033 227112 57423 SIGNALING BY GSK3BETA MUTANTS%REACTOME%R-HSA-5339716.5 Signaling by GSK3beta mutants 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME%R-HSA-9032845.3 Activated NTRK2 signals through CDK5 19353 18212 12569 12568 12064 21844 ARMS-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170984 ARMS-mediated activation 18211 109905 77480 109880 12928 54401 18049 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-HSA-947581.2 Molybdenum cofactor biosynthesis 69372 268566 68591 17434 INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME%R-HSA-168315.7 Inhibition of Host mRNA Processing and RNA Silencing 54188 54196 DEFECTIVE MAT1A CAUSES MATD%REACTOME%R-HSA-5579024.4 Defective MAT1A causes MATD 11720 CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-HSA-174184.3 Cdc20:Phospho-APC C mediated degradation of Cyclin A 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 12428 12237 107995 12427 56150 21762 22123 19179 19181 19182 217232 23996 56317 12236 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME DATABASE ID RELEASE 96%5263617 Metabolism of ingested MeSeO2H into MeSeH 50493 OAS ANTIVIRAL RESPONSE%REACTOME DATABASE ID RELEASE 96%8983711 OAS antiviral response 246727 231655 24015 230073 24014 192176 23960 211948 246728 VIRAL INFECTION PATHWAYS%REACTOME%R-HSA-9824446.5 Viral Infection Pathways 56208 66383 67443 74153 78610 22201 74244 12389 100042069 23917 171210 19877 15381 231380 22352 19298 19878 70233 67224 378425 19655 218978 218035 15516 73075 66999 269061 70616 66892 68598 67959 12609 17395 100040603 232989 269338 107701 67480 66286 72047 74326 67500 56298 17755 18452 16172 75956 18550 66861 56031 80744 69550 218490 22365 66101 19035 66270 70225 69019 18451 13684 80743 68879 28185 320632 208643 67418 212880 66585 108098 74351 83486 74370 216705 66877 56529 23983 18521 83701 12695 57905 224912 68479 56217 77573 13690 15569 209416 66172 20222 320452 67838 60321 192191 24088 21897 78334 17713 257630 66070 23845 66810 319322 12282 20683 233726 66397 19205 27967 20933 76936 171095 12412 69608 15006 218811 71702 27061 99683 68981 20639 229279 235623 240095 667803 23881 101943 81898 67439 94315 20646 27041 381379 14991 192159 77371 23806 11993 20334 67219 170779 21899 20390 53317 15382 53379 56258 66371 59013 98758 11991 68953 217365 11834 75608 234852 12362 20168 15388 18571 15387 12785 15162 228545 12526 66055 140580 16396 208092 68816 81910 66700 230861 19766 76199 67197 56532 213539 22230 54633 67465 66624 56445 73158 69192 71732 234779 53902 14827 67285 236732 223697 67958 68183 105513 76479 20963 20624 66642 233405 12229 64685 68137 75062 77134 27366 228005 76687 13205 28000 13204 246728 76938 16171 233908 66125 11931 58861 11932 11933 66824 216799 56188 12322 12323 108058 12325 16881 11928 98660 232975 57780 59095 108017 15977 12048 107686 384091 666609 216766 621705 20595 66603 53975 192656 276919 20641 20638 69731 432803 67332 257632 625018 107607 108960 103534 57377 27801 228136 75965 70546 108687 269181 57437 217664 69035 107895 20446 20444 20442 20443 17308 17158 20440 67569 14376 20447 71164 53618 20448 227619 69940 19089 208884 107338 70625 68975 234959 94112 70208 21849 13649 55948 23942 56771 80509 22154 56310 26896 16834 216848 107932 18148 100039786 19712 229542 24127 67279 21349 99982 14228 13207 100043508 18854 59024 327987 192292 17127 17128 17192 69790 22608 21762 22123 12675 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 14156 26446 19172 19173 19175 19697 13682 19177 13681 21402 16150 26443 26444 16151 19170 66413 16179 667035 22190 59029 26409 67089 75613 70247 14815 22196 621893 16401 319162 319173 319163 170743 170744 264064 142980 317677 17195 12259 83814 72512 54123 22596 13211 14375 214763 216154 51813 15469 69792 67381 15182 12387 20602 58194 23989 234366 28077 54401 171285 20662 19014 16452 328572 17087 21372 11806 103573 81004 21898 18024 15183 20185 108664 12914 268373 14225 66899 22627 56480 54131 58203 56438 108138 319583 18453 16453 16177 11771 54721 11772 50724 60406 71770 13609 20847 15980 17060 15979 58799 12518 217864 15985 15975 94246 18391 100041953 110606 26554 71954 107392 14272 232910 238247 11773 15353 68219 98985 228410 54451 108062 110611 67337 83410 18789 51786 94230 74320 68188 19645 13163 15529 216965 23888 20971 234663 19047 19386 20969 68097 71951 20970 14735 445007 57294 56455 15530 103978 14733 69912 76246 214498 103468 66317 235661 235497 14734 234865 22083 59015 54624 69736 17069 110379 68032 17289 13427 14828 19128 276891 13426 217303 22174 13424 14456 26362 17533 100732 52898 12737 21872 68705 98053 13871 225913 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 11603 231329 20021 69241 66671 17749 100043714 101772 24018 17420 67897 12572 13872 20924 23894 14884 15267 102566 404545 319168 319167 224105 105722 382014 319186 319178 319183 319182 320091 319190 12475 22031 56489 56717 319176 233246 319181 19353 20014 57261 103963 243634 56637 69038 227743 13135 19247 116871 51810 116870 14056 15170 319169 109270 67075 20846 14423 214424 328417 78303 606496 319188 67287 80285 52552 16818 671535 547253 80286 56716 68292 19092 23797 16430 382522 16451 13200 13626 319149 18108 22628 11651 11652 22324 15077 269523 18566 52615 107305 72543 19646 27681 70160 14360 194309 52348 116733 73711 13001 22088 13000 67123 100039026 330192 28084 245688 76959 66201 20479 66914 17096 12504 18005 233870 78757 100088 12774 18708 19385 18107 18607 66357 12487 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 114741 72504 21343 209361 226182 12454 229906 235459 24074 83602 58202 68153 74197 67923 27224 71586 27632 230073 24116 66641 12455 71956 72949 228607 13716 217069 63856 20817 14609 20815 16001 13051 19345 271457 19344 93687 170786 16412 94176 170762 108989 231042 227699 223921 227720 269113 66679 18141 23825 107939 69482 71805 11739 433923 11740 54563 16646 19069 15361 70699 101739 72787 19045 18226 218210 19046 27207 67097 670832 231413 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 21803 20103 668668 667739 54188 67300 672214 12757 66481 225058 100038875 100038991 68028 100043000 67891 100043295 18458 622534 238217 74568 16785 17973 666669 100040021 67025 12767 100043391 668182 241053 12317 18186 432502 100038882 19989 76808 19899 100043184 19921 19934 100043755 11545 193740 12330 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 16211 100039592 16648 19106 100037258 100043876 100043893 100043423 100042986 20115 67281 54196 76846 13480 625646 100040298 68172 13481 100042740 19951 381686 16649 70572 19384 667618 100040970 267019 56040 67248 100040331 67941 68563 14104 50528 70008 171283 14061 13712 64340 11840 622469 225027 15481 67996 51796 71713 233073 20382 110809 20383 21681 12846 108014 192170 69207 19826 75669 81897 100040029 225326 16194 69116 15568 22370 15007 12010 11768 11769 108012 11764 107975 11765 11767 252903 12759 56791 66513 93765 66589 22034 66724 68652 50868 22200 22631 75717 22629 66663 433759 22346 319189 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.6 Ion transport by P-type ATPases 11931 11932 11933 11937 11938 53313 56188 109552 67972 11941 320707 381290 12322 12323 108058 12325 11944 11945 11928 98660 69047 232975 11981 11977 57780 170759 59095 11979 108017 54670 74772 50771 319767 224079 50770 231287 268878 11980 67331 235574 66388 76295 72621 192113 50769 320940 54667 11982 640703 PACKAGING OF TELOMERE ENDS%REACTOME%R-HSA-171306.5 Packaging Of Telomere Ends 319178 319183 319182 232440 319190 319169 57321 319176 319181 28113 15267 78303 101185 319188 319152 319168 15270 21749 319167 497652 21750 624153 319186 382522 APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 96%111465 Apoptotic cleavage of cellular proteins 12387 12550 20230 21873 13511 13510 27061 21872 12367 18772 109620 13512 227753 70415 18761 223255 56215 269582 14272 18753 12169 19877 12369 14083 14453 11518 13169 18810 12368 16906 22352 11789 12370 11797 20740 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.11 Diseases of metabolism 227619 17161 13075 244209 15452 22017 13123 104086 21452 217214 11898 109900 207958 21825 227231 18408 18416 67824 11846 19300 93747 68421 109652 14854 20531 17200 18129 18131 18128 18132 12040 12041 13171 13382 12039 107476 14262 20390 93835 65969 232174 546726 71519 13078 108153 23794 30806 108154 16795 210417 271127 229595 208936 77739 381694 269959 14425 269328 230145 110119 100689 233744 235130 240322 54128 20357 16848 11504 20356 17829 27410 18636 100039649 15926 21826 12984 14598 140474 29873 12982 224116 13003 226866 110006 217734 17063 15586 18478 59048 23972 240913 223838 15212 99011 15211 237360 12032 330119 13179 14387 216725 15932 73732 12091 18295 13138 66548 11881 330267 15931 207596 12111 224697 121021 14385 56229 13004 353328 239337 68273 14595 77794 94192 279028 17022 75612 269941 108902 218271 14264 105193 20389 15529 23888 20971 14635 227697 74246 319625 20969 19025 50798 57357 14430 14583 13480 50917 16548 13481 71951 20970 75475 14735 52014 53412 14630 66789 394436 394433 19895 14043 68563 14042 67422 13115 110115 18010 15530 242585 13521 27419 103978 18563 14733 13070 53374 14629 13853 68401 14734 116847 117592 238505 11720 21351 210009 110446 269378 14377 320997 78038 243382 227095 20387 11992 72039 56357 21391 72136 667035 22190 232493 14936 74185 27357 11603 16545 67880 110821 66904 17850 109136 72157 68165 69983 14149 27029 14148 77697 109129 67096 226413 56773 72727 27047 56737 320438 208624 102580 230163 24070 208211 381903 13478 328370 13081 13072 13074 13079 20388 110948 52120 18950 11486 54219 11821 26363 57377 18976 217664 14603 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.8 Interleukin-6 family signaling 16193 16451 16880 12931 12402 16878 12702 20846 100042555 18414 16195 16156 20848 54721 218624 13019 12804 56708 12803 19247 16194 18413 16452 NEGATIVE REGULATION OF FLT3%REACTOME DATABASE ID RELEASE 96%9706369 Negative regulation of FLT3 16923 20491 12402 11352 216233 14256 667035 22190 19271 14255 77799 54607 12988 DEVELOPMENTAL CELL LINEAGES OF THE EXOCRINE PANCREAS%REACTOME%R-HSA-9820448.2 Developmental Cell Lineages of the Exocrine Pancreas 14178 16775 16776 16777 14175 16779 16780 14173 226519 14268 16782 16772 23928 16773 16774 22370 13645 14165 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME%R-HSA-2162123.6 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 15446 19224 77219 12408 100043508 19215 21391 19223 13124 105349 96979 64292 54486 66469 19225 BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME%R-HSA-9026403.2 Biosynthesis of DPAn-3-derived 13-series resolvins 11689 SARS-COV-1-MEDIATED EFFECTS ON PROGRAMMED CELL DEATH%REACTOME%R-HSA-9692913.2 SARS-CoV-1-mediated effects on programmed cell death 12048 DEFECTIVE C1GALT1C1 CAUSES TNPS%REACTOME%R-HSA-5083632.4 Defective C1GALT1C1 causes TNPS 100039649 140474 224116 269328 353328 17063 59048 94192 73732 17829 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%75953 RNA Polymerase II Transcription Initiation 270627 228980 319944 21374 216185 108143 68705 66464 98053 68776 13871 99730 66420 70439 69833 67710 245841 69920 20022 14885 72504 209357 21343 66467 209361 20020 226182 231329 20021 229906 69241 235459 66671 24074 17749 83602 100043714 68153 17420 74197 12572 13872 23894 14884 63856 RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111457 Release of apoptotic factors from the mitochondria 670717 12028 54722 66593 69146 12018 ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111446 Activation of BIM and translocation to mitochondria 26419 56455 12125 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.3 Linoleic acid (LA) metabolism 11666 68801 54326 56473 76267 54325 12686 14081 DEFECTIVE MUT CAUSES MMAM%REACTOME%R-HSA-3359478.5 Defective MUT causes MMAM 17850 109136 REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.6 Regulation of insulin secretion 18796 18797 18795 240444 16334 238076 14675 19087 19084 238276 16514 14697 12671 14710 14699 66066 14700 20910 229709 16438 16439 20927 18747 14708 14706 109905 14672 12491 14704 14695 14652 14676 16440 16500 20526 14693 268345 29875 64337 14709 14682 14701 56508 223864 12288 12286 14702 12290 14696 56808 14526 12296 19088 12297 50790 74205 14678 14677 17118 53420 14688 12289 20525 224129 233081 11512 11514 18749 22318 11551 20614 11553 20907 18750 19085 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%2142789 Ubiquinol biosynthesis 242642 76889 217707 230027 67914 56075 12850 71883 227683 52064 71365 67426 99138 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 96%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 22072 66473 100017 93835 17850 17250 54219 109136 68421 238505 65969 21452 14725 77697 210009 109129 67096 14603 19300 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.4 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome 20928 16514 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 96%1483148 Synthesis of PG 18806 110911 74451 104759 66461 18805 18807 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.3 Calmodulin induced events 12326 19088 55984 19108 19087 19084 104110 12322 12323 108058 12325 432530 210044 104111 18747 100039592 640703 224129 18753 11512 11513 110355 11514 18575 11515 18574 18573 18749 207565 18752 18750 19085 CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME DATABASE ID RELEASE 96%5674400 Constitutive Signaling by AKT1 E17K in Cancer 22084 54601 12575 17246 109270 56458 12015 56717 12371 12675 15370 67605 11651 11652 56484 606496 78757 56637 58988 227743 56716 12576 23797 18607 NURD COMPLEX ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9937850 NuRD complex assembly 216848 14377 232440 319149 13445 269610 106795 107932 22780 22779 78266 228880 15077 52004 17191 233410 11819 22778 622675 70998 14121 19646 234366 245688 22196 23942 17192 15267 70802 101631 319168 73503 319167 229542 319186 319178 319183 319182 319190 319176 319181 116871 22026 116870 319169 625328 78303 319188 15270 433759 15182 624153 18534 382522 AXON GUIDANCE%REACTOME DATABASE ID RELEASE 96%422475 Axon guidance 20437 58194 20779 20404 17295 18844 14786 223881 26413 26417 20416 327826 22325 20418 26395 26396 57257 18176 20662 19877 15461 16416 11465 21894 19878 15516 213498 110596 17395 11852 65254 319713 14587 14586 20358 19122 69632 19197 12517 69585 210801 14588 53972 114873 20346 19262 19264 216439 235611 20351 54126 12292 244058 208643 26757 19056 83433 18845 22253 11853 20349 140571 22177 18846 231148 22240 57764 623279 13508 76829 54712 12569 20361 12568 114255 18188 12933 110351 214968 11876 13449 13448 68799 226251 216963 56438 77579 71960 20354 20130 16885 16886 12830 13385 12829 12828 12827 53310 12826 13383 19164 19165 12841 100042305 208117 12840 59287 100039623 245026 12839 12835 12834 12833 67784 76709 53378 73178 11771 11772 71770 56443 22359 19699 13131 68089 67771 11867 56378 66713 18738 232910 74117 11773 218397 18749 13004 17909 18747 15529 110651 20112 14573 57294 14585 76707 14733 23939 18007 14812 14388 21844 18803 13835 76499 67071 11487 11603 227377 224105 19876 259302 223666 20563 14270 117600 19353 56637 19247 13848 13846 13845 270190 13842 13840 17390 13841 13839 13838 13837 13637 13636 13643 13642 13641 13640 13639 13638 18750 14810 22612 18710 17886 14360 13001 67268 13000 100039026 13649 17096 18708 18709 18479 18706 12288 74769 18707 18481 107449 68092 107448 433702 67923 11848 14159 73086 11461 70584 19713 16412 545156 16443 330662 243743 58226 12291 13836 239556 67938 17904 223435 232906 17880 27207 67097 670832 633683 13866 20044 27050 667279 20085 668144 12289 20084 67186 382492 20055 75617 27370 18222 65019 16410 16571 20356 629957 14083 21367 20102 53870 268721 24046 20103 11352 13844 668668 14853 16728 667739 17974 12661 16825 16392 18187 67300 20315 13429 672214 170822 13193 12757 54003 19684 66481 71745 12934 225058 17925 16536 100038875 18208 17698 100038991 225363 110862 68028 14026 104099 100043000 17690 20739 67891 18458 20740 100043295 13138 235281 622534 14852 56613 238217 214230 74947 17973 20266 16785 16870 20265 666669 16871 12805 100040021 12767 11733 67025 268902 11735 100043391 326622 14432 668182 13176 640524 241053 18186 20742 16876 20741 432502 19087 319504 238276 20743 19989 20663 26394 76808 67252 20271 19899 12331 399548 100043184 241656 20272 19921 71436 20274 19934 18643 20273 100043755 18645 103967 22323 11658 16872 110876 67031 53321 319195 20564 20269 100043209 20562 72821 68193 15399 110880 621100 22350 19941 17967 665189 269116 666899 71653 100042670 80297 15519 20264 100039316 213119 11350 22121 56705 58234 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 20450 67941 20452 12295 12296 12297 12298 74325 15481 192160 13430 21762 22123 60365 19179 19181 19182 23996 19184 68134 26440 19166 19167 26441 192170 384783 26442 19826 69077 66997 23997 66441 14389 56436 17149 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 22063 109700 66413 22065 16398 22067 667035 22066 22190 22068 59029 67089 70247 26946 16777 226519 16399 16772 16402 14783 18761 12631 20111 18717 20439 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME%R-HSA-500657.3 Presynaptic function of Kainate receptors 18796 18797 14708 14706 14702 18795 14704 14696 14807 14695 14693 64337 14709 14697 14701 14710 14699 66066 14700 14688 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.4 The activation of arylsulfatases 545260 11881 58911 11883 271970 67902 74008 77041 DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME%R-HSA-9662001.3 Defective factor VIII causes hemophilia A 22021 14069 14058 14071 22022 14061 22371 DEFECTIVE HOMOLOGOUS RECOMBINATION REPAIR (HRR) DUE TO BRCA2 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 96%9701190 Defective homologous recombination repair (HRR) due to BRCA2 loss of function 12021 81601 327762 20422 19361 114714 22427 19718 69263 15574 11920 12189 12190 235610 231724 237911 19355 57434 225182 26909 235559 12144 68275 106344 72151 68240 233826 19891 19367 19356 19362 19360 17535 21975 19363 19364 27354 TRYPTOPHAN CATABOLISM%REACTOME DATABASE ID RELEASE 96%71240 Tryptophan catabolism 107766 17254 15930 20539 70789 229905 56720 71562 234967 23923 70266 98256 209176 266645 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME%R-HSA-9617629.2 Regulation of FOXO transcriptional activity by acetylation 12914 328572 56484 54601 22166 56338 64384 56458 18519 93759 TGFBR3 REGULATES FGF2 SIGNALING%REACTOME%R-HSA-9839397.1 TGFBR3 regulates FGF2 signaling 21814 67903 14173 LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME%R-HSA-3656534.3 Loss of Function of TGFBR1 in Cancer 21803 21812 21813 17126 14225 17127 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.4 Sodium-coupled phosphate cotransporters 20515 20504 20516 20505 142681 20531 ENHANCED BINDING OF GP1BA VARIANT TO VWF MULTIMER:COLLAGEN%REACTOME%R-HSA-9845620.1 Enhanced binding of GP1BA variant to VWF multimer:collagen 14723 14724 54368 14729 22371 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME DATABASE ID RELEASE 96%3595177 Defective CHSY1 causes TPBS 269941 12111 29873 121021 13003 13004 12032 13179 DUAL INCISION IN GG-NER%REACTOME%R-HSA-5696400.3 Dual Incision in GG-NER 59001 19687 19718 56438 69263 66979 11545 13871 68058 667035 22190 18538 14885 209357 66467 11546 13870 68275 106344 72151 18971 68240 18972 22590 19891 107986 18973 18974 22592 13872 50505 23894 14884 67967 27015 99375 69745 72584 13194 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 96%77387 Insulin receptor recycling 16334 16337 242341 68775 13033 76252 11972 108664 66290 11964 110935 15925 11966 100039636 66335 11973 11974 74915 338375 21871 19268 73834 114143 66237 11975 19246 54411 27060 140494 66144 RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME%R-HSA-9633012.4 Response of EIF2AK4 (GCN2) to amino acid deficiency 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 11910 100039316 22121 27103 100043876 100043893 100043423 100042986 20115 67281 16210 76846 625646 100040298 231659 68172 100042740 19951 228775 13665 667618 67204 100040970 267019 56040 26905 67248 100040331 67941 27053 57294 11911 12611 27207 67097 670832 633683 20044 27050 11909 667279 20085 668144 20084 67186 382492 20055 12608 75617 13198 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 INTERLEUKIN-1 SIGNALING%REACTOME%R-HSA-9020702.4 Interleukin-1 signaling 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 56438 16150 26443 26444 16151 19170 192656 17874 66413 16179 26965 71481 667035 211550 22190 59029 20203 26410 26409 20210 67089 24110 103583 257632 70247 266632 80750 223664 107607 69721 73914 231130 93834 270151 11596 22059 16181 26395 67454 240518 71966 108960 59025 16178 16176 12370 22030 67245 26399 18034 26398 16177 16175 18412 434174 26406 66513 93765 66589 22034 66724 68652 21762 22123 12675 19179 19181 19182 54473 23996 19184 18033 26440 19166 18035 19167 18036 26441 11820 26442 69077 66997 23997 MET ACTIVATES PTPN11%REACTOME%R-HSA-8865999.2 MET activates PTPN11 19247 14388 15234 17295 TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 96%9013957 TLR3-mediated TICAM1-dependent programmed cell death 56532 14082 106759 12370 142980 19766 LOSS OF FUNCTION OF TP53 IN CANCER DUE TO LOSS OF TETRAMERIZATION ABILITY%REACTOME%R-HSA-9723905.2 Loss of function of TP53 in cancer due to loss of tetramerization ability 22059 METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME DATABASE ID RELEASE 96%2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 11720 269378 18113 12411 50880 140483 14711 107869 DISINHIBITION OF SNARE FORMATION%REACTOME DATABASE ID RELEASE 96%114516 Disinhibition of SNARE formation 18752 20912 18751 18750 20909 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.3 Visual phototransduction 65107 67861 18108 12057 107477 14913 11816 665270 245650 14685 20215 12788 214111 212541 14699 19892 22139 239393 11304 75624 15529 11603 23888 20971 70061 24013 20969 56307 69060 77337 109791 102294 83702 19662 71951 20970 19660 77974 19661 243923 14735 19659 18107 235033 19771 19674 14919 68453 20148 67442 14539 15530 11806 98711 238055 19682 16956 20897 103978 216454 63857 17252 55938 241452 73582 105349 14733 18761 11807 11808 14688 110606 640703 14272 79235 170752 16835 14734 11813 11814 245532 237178 14725 15485 27400 16971 225600 17921 18750 18587 18588 AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.3 Agmatine biosynthesis 242669 75986 GRB2 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-179812.4 GRB2 events in EGFR signaling 15461 15200 11839 13649 21802 13645 12223 18176 71920 20662 13874 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-HSA-446193.3 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 20448 15275 50935 192156 67311 225742 236082 107652 26938 20451 380959 19703 245847 227697 20445 20449 54342 19025 50798 54613 66174 57357 50877 56174 14583 13480 14584 234730 13481 22122 241230 207958 75540 228368 66248 24060 240119 218138 20454 109785 52014 12764 56737 20450 320438 66789 57170 208624 69064 102580 94181 24070 74091 208211 68563 381903 67422 13478 20452 328370 18010 241159 23956 235504 110119 69080 331026 29858 54128 20446 20444 20442 20443 20440 12091 20447 ZNF598 AND THE RIBOSOME-ASSOCIATED QUALITY TRIGGER (RQT) COMPLEX DISSOCIATE A RIBOSOME STALLED ON A NO-GO MRNA%REACTOME DATABASE ID RELEASE 96%9954716 ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA 622534 238217 75452 16785 77987 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 66105 667035 22190 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 213753 57294 100041766 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 216080 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 96%400206 Regulation of lipid metabolism by PPARalpha 20602 23989 59024 18631 327987 70625 68975 14081 234959 94112 28077 70208 12491 20182 20186 171285 13122 11520 56771 50493 228775 80509 67224 19014 229003 11655 11865 66999 328572 11606 394434 21372 11624 109151 11622 11806 17977 73690 19017 18143 13076 17436 17978 59035 81004 66993 24001 69790 56310 12753 26896 15183 20185 217166 107765 12896 12914 56406 108098 76267 14200 18670 15360 66172 170826 192191 14373 26457 78334 94185 14137 100040592 20683 195733 18044 20933 18045 18046 20788 75613 381379 17764 22260 20181 67219 19013 19883 26379 19016 12894 18181 264064 19731 67544 230753 76199 67279 57875 22259 11303 66113 100040843 11807 11364 11863 11864 17979 216154 51813 14080 20859 69792 20466 67381 FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME%R-HSA-8854050.4 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 231863 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 21762 22123 20878 19179 19181 19182 23996 19184 26440 19166 448987 19167 26441 26442 69077 66997 23997 FORMATION OF THE POLYBROMO-BAF (PBAF) COMPLEX%REACTOME%R-HSA-9933939.1 Formation of the polybromo-BAF (pBAF) complex 66923 67155 26992 20586 20588 20587 56456 68094 83796 66993 83797 57376 12055 12054 11461 77045 72057 77044 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME%R-HSA-9672383.3 Defective factor IX causes thrombophilia 14069 14058 14071 ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.5 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 30939 18005 12428 12237 107995 12427 56150 21762 22123 19179 19181 19182 217232 23996 56317 12236 19184 59008 18817 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 DEFECTIVE CD320 CAUSES MMATC%REACTOME DATABASE ID RELEASE 96%3359485 Defective CD320 causes MMATC 54219 21452 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME%R-HSA-5619078.3 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) 228368 ENTEROBACTERIAL FACTORS ANTAGONIZE HOST DEFENSE%REACTOME%R-HSA-9956593.3 Enterobacterial factors antagonize host defense 55932 640703 12363 667035 100041766 22190 236573 14469 DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 96%5693606 DNA Double Strand Break Response 70620 667035 22190 107823 68251 20184 240087 11350 70681 70238 27223 100039592 107976 210766 19060 104416 22059 59004 225896 14051 22196 93762 22385 11785 15204 230674 19360 14050 14049 17535 14048 319186 27354 12021 319178 319183 319182 81601 50883 319190 319181 11920 12189 319152 93765 193796 26419 78303 319188 15270 382522 MEIOTIC SYNAPSIS%REACTOME DATABASE ID RELEASE 96%1221632 Meiotic synapsis 319178 319183 319182 232440 319190 57321 319176 223697 319181 12189 319152 21749 497652 21750 13006 319169 94244 20842 22196 28113 56739 78303 15267 140557 101185 319188 50878 15270 319168 20962 74075 16906 319167 320558 24061 64009 319565 71846 624153 66654 20957 75459 20843 19357 319186 77053 15512 382522 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME DATABASE ID RELEASE 96%420597 Nectin Necl trans heterodimerization 58998 71740 58235 19294 94332 54725 CARDIOGENESIS%REACTOME DATABASE ID RELEASE 96%9733709 Cardiogenesis 20807 81601 54601 12387 13813 20997 57246 14465 17292 16842 21380 21388 15110 18091 214384 12180 14463 17260 140858 15213 14534 15214 17125 15111 17128 16825 16392 G1 S TRANSITION%REACTOME%R-HSA-69206.4 G1 S Transition 17187 12534 12575 211586 13555 19645 21781 12567 12443 11651 12566 11652 12447 27401 12448 20135 12576 19646 12545 17869 73699 22171 21877 13361 19052 19053 51792 12428 17216 17215 17217 17218 17219 17220 12544 50496 13559 104394 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 19650 26441 19651 63955 22390 26442 72568 69077 66997 12530 231506 23997 629959 54124 56436 27214 20459 17463 67177 75660 57296 23834 20422 26445 26446 57441 19172 70024 19173 19175 19177 21402 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18969 18968 66671 19075 19076 17420 12572 59001 67141 66979 50793 18392 18393 66634 26428 26429 56452 18538 68275 68240 19891 18973 18974 433759 23797 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.4 Mitochondrial transcription termination 208595 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME%R-HSA-5619089.4 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) 104245 HDL CLEARANCE%REACTOME%R-HSA-8964011.2 HDL clearance 93835 11806 110611 65969 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.6 TP53 Regulates Transcription of Cell Cycle Genes 29813 328572 12532 59092 78893 13496 12534 69125 18983 12428 12575 211586 13555 219103 52846 21781 12566 59035 20620 231464 12028 12447 18148 12227 66214 12448 58184 12576 18538 52679 104394 234594 12795 15469 12427 55948 22059 13197 20878 108961 53621 72068 232791 104625 19650 228140 19651 TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME DATABASE ID RELEASE 96%5357786 TNFR1-induced proapoptotic signaling 56480 22030 56489 11796 11798 21937 71648 30941 229603 22258 268749 106025 21926 74256 53376 263876 76580 71609 21929 14082 24105 12370 19766 11797 RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 96%5660526 Response to metal ions 13007 17752 104069 17748 17750 17751 17764 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 21943 53859 22030 72049 22031 50930 21944 11796 21934 21947 27279 24099 17000 16994 16992 11797 ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 96%2473224 Antagonism of Activin by Follistatin 14313 83554 16324 16323 GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.9 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 14702 240444 14696 14526 19088 238076 19087 19084 238276 14697 14710 14699 66066 14700 16438 16439 14688 18747 14708 109905 14706 14704 14695 14652 224129 16440 11512 16500 14693 11514 268345 29875 64337 14709 18749 14701 56508 223864 19085 PROTEIN UBIQUITINATION%REACTOME%R-HSA-8852135.4 Protein ubiquitination 50933 22201 22209 53323 70620 140499 269523 12042 66105 22213 667035 67128 22190 22214 67615 268470 66799 109331 231380 67196 15007 22195 319186 319178 319183 319182 319190 22225 19090 22284 319181 109161 22193 100041766 216150 93765 68366 18538 20585 76246 108089 214498 225131 67819 56273 66317 668173 103737 72129 252870 19302 235497 66510 22083 268281 68441 109815 432940 233900 320311 54624 78303 319188 216080 68612 22210 22194 58186 100039535 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 96%9662360 Sensory processing of sound by inner hair cells of the cochlea 13823 17913 227357 192140 13409 238021 332309 97031 20742 56506 102502 224796 72088 67972 98845 328789 56226 60613 16531 433899 16533 13860 17886 329421 22350 19230 19339 13002 20964 56808 12296 240899 83762 26875 12343 12345 12217 12289 216227 29866 20977 12340 241431 73750 12361 140476 16470 17910 22318 19684 23999 20614 22295 17921 20907 17698 667663 381375 193385 20776 20740 11994 ELASTIC FIBRE FORMATION%REACTOME DATABASE ID RELEASE 96%1566948 Elastic fibre formation 16998 16949 94352 16950 320910 67573 12159 108075 16420 241226 12154 16419 18550 17150 216760 76293 14115 14114 12162 50530 23876 216616 14119 12156 58859 16412 14563 13717 16410 16416 21803 21808 16402 14118 22370 21809 268977 16997 16948 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 96%448424 Interleukin-17 signaling 12234 257630 171095 21402 73086 16150 16151 192656 16179 26965 667035 26416 22190 17258 26410 26409 26413 103583 257632 26417 107607 19094 102626 231130 73699 26395 110651 108960 20112 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 21770 26399 26400 26398 26420 13712 26414 16172 26397 17260 66513 93765 66589 23939 50905 22034 66724 68652 16171 20111 11909 26419 12675 140806 16476 18033 234836 57890 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME%R-HSA-110328.4 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 319178 319183 319182 232440 319190 57321 319176 319181 17193 234258 71726 319152 382913 18294 21749 72774 497652 18207 21750 319169 28113 15267 78303 101185 319188 319168 15270 319167 624153 319186 382522 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559586 DNA Damage Telomere Stress Induced Senescence 232440 12575 19645 12566 12447 12448 12576 22059 15364 28113 15267 101185 15260 319168 319167 19360 75560 56702 50709 17535 14957 50708 14958 319186 27354 319178 319183 319182 81601 80838 66403 12428 319190 15361 57321 319176 319181 11920 319152 104248 21749 497652 21750 319169 12427 170644 78303 319188 15270 16906 624153 382522 IMATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669917.2 Imatinib-resistant KIT mutants 16590 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 96%3238698 WNT ligand biogenesis and trafficking 73130 93735 22415 22413 22416 22420 22418 22422 22412 22421 216795 22423 22410 20890 22414 22411 22408 22409 53627 22417 68151 22419 56433 30930 65114 54198 RET SIGNALING%REACTOME DATABASE ID RELEASE 96%8853659 RET signaling 14389 13449 74769 13448 18707 14573 14783 14587 14586 14585 14786 18710 19197 14588 23939 19247 20416 327826 18747 19713 20418 58234 14388 20662 18749 623279 18803 76829 114255 18750 18708 384783 18188 18709 110351 18706 11876 BIOSYNTHESIS OF LIPOXINS (LX)%REACTOME%R-HSA-2142700.7 Biosynthesis of Lipoxins (LX) 67103 15446 17001 11684 11690 11689 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME%R-HSA-6811558.5 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling 268980 18183 83961 320207 100042150 20779 17295 11651 22324 18710 14255 26413 26417 14360 327826 13649 21802 73699 19052 19053 51792 30955 18708 18709 18706 226849 108083 225849 74769 18707 26931 12487 21770 12519 26932 12524 12223 71920 13874 15200 211323 77125 19354 12064 14388 15234 17082 18212 18205 78405 11839 13645 80903 384783 14186 14165 83490 18596 14389 77647 16367 18213 14172 80857 16334 14170 14180 14178 14177 67112 64654 14175 14174 14173 14164 83379 17874 16179 13983 266632 13982 18595 15937 12478 18591 56212 16337 18718 19353 14256 19247 22034 104709 13866 18720 18719 18717 16818 16590 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-5633008.4 TP53 Regulates Transcription of Cell Death Genes 56187 19352 209456 225655 21933 69076 60599 11920 12662 22061 16009 66813 22062 71361 12028 12122 64058 68428 12914 66494 17988 11799 12177 22059 57913 14102 68742 12366 268973 11783 12362 12368 21981 12905 12053 PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.4 PI-3K cascade:FGFR1 327826 80857 14180 14177 67112 64654 14175 14174 14388 14173 14164 18708 19247 14165 18706 DISEASE%REACTOME%R-HSA-1643685.19 Disease 56208 66383 67443 78610 117591 12389 114479 18126 22325 15452 22017 100042069 23917 57257 171210 19877 15381 11465 22352 19298 19878 70233 67224 378425 19655 218978 218035 15516 73075 66999 269061 70616 66892 68598 67959 12539 12609 17395 100040603 232989 269338 107701 67480 66286 72047 74326 67500 56298 17755 18452 16172 75956 18550 66861 56031 21812 80744 21813 69550 218490 22365 66101 19035 66270 70225 69019 18451 13684 80743 18655 68879 28185 320632 208643 67418 22084 212880 66585 108098 74351 83486 74370 216705 66877 56529 23983 18521 67605 83701 57905 68479 109652 77573 56216 13690 20980 15569 64176 209416 22317 66172 64051 20222 22318 320452 20614 67838 20979 60321 20907 192191 75209 24088 11789 21897 20505 14469 142681 78334 20531 17713 257630 66070 23845 66810 319322 12282 20683 233726 66397 19205 27967 20933 76936 171095 12412 69608 15006 218811 71702 27061 99683 68981 20639 229279 235623 240095 667803 23881 101943 81898 67439 94315 107476 20646 27041 381379 14991 14262 192159 71514 77371 23806 11993 55932 20334 67219 170779 21899 20390 53317 15382 70686 170761 53379 56258 66371 59013 14939 98758 11991 68953 217365 16176 11834 75608 234852 12362 20168 15388 18571 15387 12363 12785 228545 66055 17002 16396 236573 208092 68816 12370 81910 66700 230861 19766 76199 67197 56532 213539 22230 54633 16173 67465 22030 66624 56445 73158 69192 12721 71732 69146 53902 14827 67285 236732 223697 67958 68183 105513 76479 16175 20624 66642 54722 233405 434174 64685 71609 68137 14082 75062 20520 77134 27366 228005 76687 13205 28000 13204 246728 76938 16171 233908 66125 67561 11931 11932 11933 56188 16514 12322 12323 108058 12325 229709 16438 16439 18747 11928 98660 232975 117149 12491 57780 20193 16440 53627 59095 20928 108017 238037 22166 14630 17246 26400 26398 26420 12578 16193 14629 15977 26419 12608 12064 14388 18212 18205 107971 78405 18803 11839 13645 12048 13629 67160 18011 13388 16449 240055 225164 11487 54485 11491 16450 107686 384091 666609 216766 621705 20595 66603 53975 276919 20641 20638 69731 432803 67332 76007 20927 12266 625018 14917 69983 226413 229782 56774 30962 20532 74338 20510 102680 20512 20540 246049 17254 103534 57377 27801 228136 75965 70546 108687 269181 57437 217664 69035 107895 20446 20444 20442 20443 17308 17158 20440 67569 14376 20447 71164 53618 20448 227619 19089 208884 12326 217344 20620 93671 16153 17886 70625 68975 234959 94112 15213 70208 21849 13649 14184 21802 74126 14723 55948 23942 56771 50493 21825 80509 22160 14539 16477 56310 26896 103988 14534 19664 216848 232232 17200 18129 18131 18132 107932 170787 18148 19211 100039786 19712 229542 67279 70315 21349 13866 216227 18519 15370 18478 18854 79221 59024 327987 192292 11350 67384 17126 17127 17128 17192 58992 16621 75475 103806 333639 69790 22608 16653 381022 14377 56458 16179 13983 75613 16399 16401 16154 56338 264064 18591 54601 83814 15185 15184 216154 51813 15469 69792 15205 20466 67381 15182 20602 23989 270118 12005 234366 28077 56233 224139 15214 171285 194231 54519 29875 245684 22371 16416 110157 23980 14161 21894 207958 215449 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 16706 13191 18174 74591 53945 27413 11416 27421 20521 19300 108664 54403 20538 238384 26569 246787 22232 23985 72027 13487 74104 20501 104245 12215 20516 15203 18670 68421 28253 170441 71279 317750 12870 24059 56480 54131 58203 236794 331004 12040 12041 13171 13382 12039 14235 18646 54167 232679 93835 19682 18453 65969 232174 11303 11771 546726 11772 71770 232910 11773 110611 18749 15926 12984 12982 23971 23972 14387 18295 14385 14595 15275 17022 75612 269941 108902 218271 14264 105193 15529 23888 20971 14635 74246 319625 20969 14430 50917 16548 71951 20970 14735 53412 19895 14043 14042 15530 13521 27419 13806 103978 18563 235504 14733 53374 13070 13853 68401 20525 14734 116847 117592 21351 21391 72136 225913 232493 14936 74185 27357 11304 11603 16545 67880 231103 72157 27029 56773 72727 27047 56737 320438 208624 230163 102580 24070 208211 381903 13478 328370 12475 22031 56489 106759 13072 13079 14256 116871 51810 116870 18950 11486 11821 67470 27409 14423 214424 328417 606496 67287 80285 52552 671535 547253 19092 17161 78798 268980 13666 215114 12211 19043 19084 14025 11682 234258 18294 72774 18207 107305 72543 27681 70160 194309 52348 116733 73711 22088 67123 330192 28084 76959 66201 20479 66914 233870 360013 432508 67529 13047 83490 18596 93687 77647 18213 12057 170786 19349 22139 16573 16412 140579 94176 330662 20430 59079 56212 19045 19046 110119 54128 14083 27410 17925 18458 13138 17973 12767 18186 19087 227697 19025 50798 57357 14583 13480 67533 13481 228368 24060 52014 68563 67422 18010 50528 70008 171283 12223 71920 13874 13712 15200 18412 11840 15481 17210 116849 238505 11720 210009 269378 12846 80903 384783 75669 14186 14165 81897 14389 16367 14172 80857 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 14164 83379 12780 16194 69116 56791 380928 50868 22200 75717 66663 22346 74153 22201 74244 13123 104086 21452 75590 231380 18218 63953 672511 15234 12695 224912 56217 14854 13017 13016 50884 83767 329165 71893 110279 105855 242687 237038 11308 241275 13057 108100 101314 18969 18968 13436 13435 13433 19075 19076 12261 18595 20537 20526 13162 19164 19165 15208 100042305 208117 59287 77974 100039623 56198 18400 15162 12526 140580 109637 17075 19088 234779 17918 19108 12499 12267 20897 76709 73178 104110 20963 14678 14677 12229 56443 14687 19200 14679 432530 210044 104111 80987 68089 67771 11867 54483 56378 18438 66713 74117 13542 70086 224129 245880 11512 11513 11514 11515 14191 13544 13543 22376 215280 14598 18439 319446 68524 67955 13035 11541 23959 23887 17882 14129 242851 19085 17913 13479 58861 246256 14131 17909 66824 330319 216799 76884 12495 19720 21951 74493 16881 12527 19771 211323 79235 192656 17874 214111 257632 266632 53791 107607 108960 19662 235584 67603 26372 56463 26936 19659 21848 11774 330286 67726 100986 78781 19317 11610 76156 210106 66549 16905 67095 14359 69923 338523 75296 69940 107338 109181 234130 73016 84035 56811 207742 16974 13380 16973 22154 16593 16834 54214 70297 14724 54368 14729 24127 20851 20850 18712 50490 14784 71519 13078 99982 14228 13207 107351 100043508 17698 108147 20742 14183 394436 394433 242585 21762 22123 12675 19179 19181 19182 23996 110446 19184 18033 26440 19166 18035 19167 18036 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 14156 26446 19172 19173 19175 19697 13682 19177 13681 21402 16150 26443 26444 16151 19170 66413 26965 667035 22190 59029 26409 67089 70247 13982 14815 208727 22196 621893 319162 319173 319163 170743 19360 58988 170744 17535 21975 54445 19363 142980 19364 27354 12021 317677 17195 81601 17532 327762 12259 19361 56392 114714 22427 19718 69263 15574 109821 11920 12189 12190 72512 235610 54123 231724 237911 19355 22596 57434 13211 225182 14375 214763 20388 26909 235559 12144 68275 14067 106344 69162 72151 68240 233826 19891 19367 19356 19362 217232 56317 59008 14069 66156 216080 69957 17222 21787 75430 68612 52563 22194 68999 52206 100039535 52717 99152 668450 12388 12387 58194 12550 20408 12402 56324 20779 15239 20404 17295 20844 20405 13858 104836 109880 26416 12928 13075 26413 26417 20416 327826 109905 54401 26395 26396 18176 20662 15461 217214 11898 109900 227231 18408 18416 67824 11846 19014 328572 15129 17087 15368 15122 21372 11806 103573 81004 21898 18024 15183 20185 12914 640703 268373 14225 12334 12336 11666 20656 56484 16476 69543 18477 21672 16542 16906 66899 22627 14011 12569 668218 12568 11820 99412 12125 12530 12531 14103 12532 12380 12333 63993 18128 56438 14697 14710 14699 66066 14700 14708 14706 14704 14695 14693 20423 64337 14709 108138 14701 319583 13363 14702 14696 14367 14366 22416 16453 16177 22418 54721 14370 50724 60406 13609 20847 15980 17060 15979 14368 58799 12518 14369 217864 15985 15975 94246 14688 18391 100041953 16147 110606 26554 71954 107392 18015 14272 238247 15353 68219 101809 98985 228410 114715 54451 114716 108062 67337 83410 18789 51786 94230 74320 68188 29873 13003 110006 15586 15212 15211 12032 13179 15932 12091 11881 15931 12111 121021 13004 12575 22589 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 56371 27401 13163 20389 12448 12577 12576 14255 14182 20495 216965 20497 234663 107723 19047 19386 73699 12015 12371 68097 19052 19053 51792 445007 226849 225849 26931 21770 26932 57294 56455 69912 76246 214498 103468 66317 235661 235497 56430 234865 22083 59015 54624 69736 17069 110379 68032 17289 13427 14828 19128 276891 13426 217303 22174 13424 14456 26362 17533 100732 18861 52898 17685 12737 17686 17350 320997 17688 11998 20387 54140 26361 12000 16364 21872 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 101772 110821 24018 66904 17420 17850 67897 12572 109136 13872 20924 23894 14884 68165 14149 14148 77697 109129 15267 102566 67096 404545 319168 319167 224105 226144 105722 382014 76850 239528 319186 319178 319183 319182 193670 54197 236511 320091 319190 13081 56717 70377 319176 18034 233246 216440 319181 19353 20014 57261 103963 217351 243634 56637 214150 69038 227743 13135 19247 66753 110948 104709 67819 14056 15170 116891 17454 20338 319169 109270 54219 67075 26363 20846 20848 625328 78303 319188 15270 16818 80286 56716 624153 14603 68292 23797 16430 382522 16451 232440 13200 13626 319149 18108 22628 18183 320207 83961 100042150 22612 11651 11652 22324 15077 12047 269523 66310 18710 140858 18566 52615 244209 19646 213464 14360 12988 13001 13000 100039026 17869 245688 12502 17096 12638 23808 12504 244373 18005 78757 76580 100088 30955 12774 18708 19385 18709 18107 18706 18607 74769 18707 66357 12487 12519 12524 21416 270627 68092 228980 319944 21374 433702 20922 20833 216185 108143 66464 68776 99730 70439 67655 21399 107951 57314 19354 114741 20201 72504 20202 21343 209361 93747 226182 12454 229906 235459 24074 83602 58202 68153 74197 67923 19123 27224 71586 27632 230073 24116 66641 12455 71956 72949 228607 13716 217069 63856 20817 14609 20815 16001 13051 19345 271457 19344 20533 19743 11461 22059 170762 108989 231042 227699 223921 227720 269113 66679 18141 23825 107939 69482 71805 11739 433923 11740 54563 16646 226861 19069 15361 70699 101739 72787 18226 218210 59069 19248 108153 23794 30806 108154 16795 27207 210417 67097 271127 670832 229595 231413 208936 633683 77739 20044 381694 27050 269959 667279 14425 20085 269328 668144 230145 20084 100689 67186 233744 382492 235130 20055 240322 75617 20357 27370 16848 65019 11504 629957 20356 20102 17829 21803 18636 20103 100039649 668668 21826 667739 140474 54188 224116 67300 226866 672214 217734 12757 17063 66481 59048 225058 240913 100038875 223838 100038991 99011 68028 237360 100043000 330119 67891 216725 100043295 73732 622534 66548 238217 330267 74568 207596 16785 224697 666669 56229 100040021 353328 67025 239337 100043391 68273 668182 77794 241053 94192 12317 279028 432502 100038882 19989 76808 19899 100043184 19921 19934 100043755 11545 193740 12330 319195 100043209 68193 621100 19941 665189 666899 100042670 15519 100039316 22121 16211 100039592 16648 19106 100037258 100043876 100043893 100043423 100042986 20115 67281 54196 76846 625646 100040298 68172 100042740 19951 381686 16649 70572 19384 667618 100040970 267019 56040 67248 100040331 67941 66789 13115 14104 110115 14061 64340 622469 225027 67996 51796 71713 233073 20382 110809 20383 21681 108014 192170 69207 19826 22637 100040029 78038 243382 227095 11992 72039 56357 72345 22021 56316 14058 14071 22022 14268 15568 22370 15007 12010 12258 11768 11769 12478 108012 11764 107975 11765 11767 252903 12759 13074 100041766 66513 93765 66589 22034 66724 68652 52120 242864 17169 22631 22629 27267 18976 433759 16590 319189 CASP4-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960519 CASP4-mediated substrate cleavage 12367 16176 16173 12363 69146 TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME%R-HSA-8853884.3 Transcriptional Regulation by VENTX 52717 233833 99152 668450 12387 236511 21416 110147 19697 16842 12443 213988 217351 56371 214150 12578 16193 17454 12608 22059 217232 56317 77683 59008 18033 66156 216080 69957 17222 75430 68612 12978 52563 22194 76850 68999 52206 100039535 CHOLESTEROL BIOSYNTHESIS VIA DESMOSTEROL (BLOCH PATHWAY)%REACTOME DATABASE ID RELEASE 96%6807047 Cholesterol biosynthesis via desmosterol (Bloch pathway) 73166 13595 15490 98386 13121 13360 74754 235293 66234 18194 LYSINE CATABOLISM%REACTOME DATABASE ID RELEASE 96%71064 Lysine catabolism 235386 78920 13382 30956 110695 23923 19193 209692 270076 12971 217593 72947 REGULATION OF CLOTTING CASCADE%REACTOME DATABASE ID RELEASE 96%9769739 Regulation of clotting cascade 19152 14066 217847 279028 14068 11905 15160 14058 14071 66901 18787 15529 11603 23888 20971 20969 14723 22371 71951 20970 58992 16621 14735 12258 105722 14724 56744 54368 14729 15530 21824 233246 109821 14062 20720 14061 268591 103978 19124 20597 68891 14733 14067 385643 14734 19123 14069 19128 11820 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 96%9656256 Defective OGG1 Substrate Processing 18294 TRANSCRIPTIONAL REGULATION BY NPAS4%REACTOME DATABASE ID RELEASE 96%9634815 Transcriptional Regulation by NPAS4 233833 20807 16334 236511 17246 59027 243621 225872 56461 103573 213988 20620 217351 214150 11863 26413 26417 11864 12914 52897 19712 54526 19713 17454 14815 12064 14579 14281 12569 12568 11865 76850 239528 STRAND-ASYNCHRONOUS MITOCHONDRIAL DNA REPLICATION%REACTOME%R-HSA-9913635.2 Strand-asynchronous mitochondrial DNA replication 216151 74528 208194 381760 226153 21975 19819 50776 18975 COLLAGEN FORMATION%REACTOME%R-HSA-1474290.5 Collagen formation 26432 26433 210530 56401 76477 18542 234407 192897 69675 16403 12817 12816 12815 24087 12814 21892 12831 12153 12813 94216 12830 373864 12821 107581 77018 12819 53867 12829 12828 12827 12826 12825 69700 12824 16780 12822 71355 12841 16782 12823 73368 18810 12840 213945 16774 12818 245026 140709 13040 237759 12839 13030 329941 12837 12836 12835 12834 16948 12833 12843 16949 12832 12842 94352 16950 67573 17395 13039 17392 17386 18453 18452 19035 18451 30800 12476 320452 17393 56693 269132 237360 14789 330119 12406 216725 18822 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 96%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 11438 110834 11449 11448 11447 108015 11444 MET ACTIVATES RAP1 AND RAC1%REACTOME%R-HSA-8875555.2 MET activates RAP1 and RAC1 19353 109905 107746 12929 215449 12928 67299 14388 15234 17295 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 96%5661270 Formation of xylulose-5-phosphate 68631 102448 67880 20322 58810 RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 96%8935964 RUNX1 regulates expression of components of tight junctions 12741 12400 21872 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 96%8878166 Transcriptional regulation by RUNX2 12020 12534 20682 56275 12575 19645 20779 12567 22612 12443 11651 11652 13345 27401 97064 16656 26413 26417 107568 15213 11350 15214 22601 17125 15111 17128 17130 22160 17132 13395 12400 19017 16854 53892 223272 68527 15183 21762 22123 14634 14633 19179 19181 19182 23996 19184 75788 26440 19166 170826 19167 170574 26441 26442 69077 66997 23997 56436 17463 57296 20422 26445 225207 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 13982 11835 14815 26379 208727 16402 12842 17386 56424 12028 15185 56637 16147 12156 212712 15205 20846 17702 23797 IRS ACTIVATION%REACTOME DATABASE ID RELEASE 96%74713 IRS activation 16367 16334 14783 384783 16337 REGULATION OF NF-KAPPA B SIGNALING%REACTOME DATABASE ID RELEASE 96%9758274 Regulation of NF-kappa B signaling 80750 223664 22030 270151 67454 22059 12675 16150 59025 16151 667035 22190 24110 22034 12370 CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-HSA-446353.3 Cell-extracellular matrix interactions 109711 16412 73341 68794 20163 21754 19303 170736 22323 74202 57342 218952 16202 225341 192176 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME DATABASE ID RELEASE 96%379397 Enzymatic degradation of dopamine by COMT 17161 12846 791260 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME%R-HSA-389960.4 Formation of tubulin folding intermediates by CCT TriC 12469 12461 12464 73710 22145 53857 12465 22152 545486 227613 238463 22153 12466 22147 21454 12462 22142 22151 22146 12467 12468 22143 67951 REGULATION BY C-FLIP%REACTOME DATABASE ID RELEASE 96%3371378 Regulation by c-FLIP 14103 22030 71609 14082 22035 21933 12370 19766 14102 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190371 FGFR3b ligand binding and activation 14172 80857 14180 14164 INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 96%9705462 Inactivation of CSF3 (G-CSF) signaling 12986 16451 19823 67923 75717 12702 17096 20846 20851 20848 20850 54721 20963 66105 12985 216080 667035 100041766 15162 22190 12703 16452 ENDOSOMAL VACUOLAR PATHWAY%REACTOME%R-HSA-1236977.3 Endosomal Vacuolar pathway 240095 667803 13039 15007 13040 12010 15006 14991 240028 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.5 Pyrimidine biosynthesis 22247 69719 56749 ATF6B (ATF6-BETA) ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 96%8874177 ATF6B (ATF6-beta) activates chaperones 12915 270669 14828 56453 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME DATABASE ID RELEASE 96%75892 Platelet Adhesion to exposed collagen 213119 16412 14127 243816 14723 279028 17096 22371 109700 16398 14724 54368 14360 14729 REGULATION OF PYRUVATE METABOLISM%REACTOME DATABASE ID RELEASE 96%9861718 Regulation of pyruvate metabolism 14874 17436 667035 22190 13382 27418 74125 226757 56705 381511 68263 228026 18604 236900 27273 68477 75387 18004 66089 27402 18597 18598 382051 319518 16828 66771 76425 59003 235339 INTERLEUKIN-1 PROCESSING%REACTOME%R-HSA-448706.3 Interleukin-1 processing 16176 16175 12362 16173 18033 13035 19697 69146 18034 KINESINS%REACTOME DATABASE ID RELEASE 96%983189 Kinesins 26934 74947 16570 16594 229841 668303 16579 232943 240641 269152 19348 16565 16564 16552 71819 16580 16581 16593 16551 16561 110033 16562 16558 209737 70218 73470 74764 16563 75050 16554 286942 16568 16578 319991 16572 16573 16560 16569 16571 73804 228421 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME%R-HSA-168330.5 Viral RNP Complexes in the Host Cell Nucleus 193740 METABOLISM OF POLYAMINES%REACTOME DATABASE ID RELEASE 96%351202 Metabolism of polyamines 56436 242669 17463 57296 54375 20422 26445 26446 20810 19172 19173 19175 671878 75986 19177 26443 26444 19170 66413 18104 20229 59029 67089 70247 18247 18245 18263 21762 22123 19179 212503 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 53814 23997 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME%R-HSA-5619104.4 Defective SLC12A1 causes Bartter syndrome 1 (BS1) 20495 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 96%446203 Asparagine N-linked glycosylation 193813 12068 53618 317717 20448 56494 227619 60409 19089 89867 13200 235416 216131 107338 67231 66890 269523 338366 12640 224139 21802 74126 207958 53598 66357 56444 67665 104318 22428 13191 192193 12344 59288 105785 66967 223455 66597 320011 108123 23802 108124 22644 66435 75841 76332 16834 102339 99412 338337 17957 67542 66397 97484 233824 69608 218811 99683 192156 56418 70361 77371 380959 20334 66251 56447 54161 225896 12836 11889 11890 59007 56389 59042 14827 56395 16866 68137 66913 12343 12345 98388 11842 110119 69080 331026 29858 50797 12340 54128 70349 12847 20739 20740 12091 54160 11733 11735 14595 66111 640524 15275 20742 12317 20741 54399 20743 217615 50935 12330 67311 68947 225742 236082 107652 26938 80297 20451 19703 245847 234663 227697 20445 20449 54342 19025 109154 14422 50798 54613 66174 213827 57357 50877 11844 56174 53334 14583 22242 13480 14584 68097 234730 13481 22122 241230 217364 75540 67511 228368 66248 56358 24060 240119 218138 20454 109785 52014 12764 20450 66789 57170 69064 94181 74091 68563 67422 14799 20452 18010 241159 56455 23956 71665 56336 56386 235504 242362 11840 19359 64138 235661 18195 19179 57370 53418 56375 110379 11839 13427 13426 13424 16334 17309 667035 22190 77038 56737 320438 208624 102580 24070 208211 193670 381903 54197 13478 328370 69654 216440 20014 228998 103963 69038 17155 67091 13135 17156 20703 230815 11843 66226 19324 105522 243819 14067 69162 67819 14275 12793 67857 100042773 116891 20333 215474 20338 207352 74498 66682 103534 52036 67075 57377 76983 13032 245828 12794 54130 240667 108687 67727 269181 214895 59005 217664 14069 78232 107895 56041 20446 333883 20444 21787 20442 27096 80286 20443 72978 17308 227648 17158 76308 68292 20440 76510 67569 100042343 16430 14376 50907 20447 INTERLEUKIN-6 SIGNALING%REACTOME%R-HSA-1059683.5 Interleukin-6 signaling 16193 20848 54721 16451 12402 16194 19247 16452 12702 20846 16195 SIGNALING BY NODAL%REACTOME%R-HSA-1181150.3 Signaling by NODAL 14106 66556 620395 11481 17126 23863 17127 12622 17128 18119 13590 269275 11479 56484 18550 18553 11480 320202 26413 26417 DNA METHYLATION%REACTOME%R-HSA-5334118.3 DNA methylation 319178 319183 319182 232440 319190 319149 319176 319181 15077 13436 18140 13435 13433 319169 625328 54427 15267 78303 319188 319168 15270 319167 624153 319186 382522 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 96%111461 Cytochrome c-mediated apoptotic response 56369 12367 670717 11783 74268 72565 66593 12371 26413 11798 26417 12369 REGULATION OF IFNG SIGNALING%REACTOME DATABASE ID RELEASE 96%877312 Regulation of IFNG signaling 16451 56469 15170 15980 19246 15979 12703 19247 16452 12702 15978 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME%R-HSA-5619062.4 Defective SLC1A3 causes episodic ataxia 6 (EA6) 20512 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME DATABASE ID RELEASE 96%5654221 Phospholipase C-mediated cascade; FGFR2 14172 80857 14180 14178 14177 67112 64654 14175 14174 14173 14164 18803 80903 14165 CHD1 AND CHD2 SUBFAMILY%REACTOME DATABASE ID RELEASE 96%9943411 CHD1 and CHD2 subfamily 319322 232440 319149 27967 107686 384091 666609 68981 21423 20639 15077 20641 101943 20638 81898 20646 67332 21406 15267 319168 319167 66055 319186 319178 319183 67959 319182 67465 319190 107701 72047 319176 319181 67958 20833 76479 75062 12648 244059 114741 76246 13204 214498 76938 66317 66125 212880 21413 235497 319169 22083 17927 17928 54624 68479 625328 78303 319188 15270 20222 624153 382522 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1306955.5 GRB7 events in ERBB2 signaling 13866 211323 14786 100042150 DNA DAMAGE REVERSAL%REACTOME%R-HSA-73942.4 DNA Damage Reversal 268420 69113 69090 75452 17314 77987 231642 26383 POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME%R-HSA-389977.4 Post-chaperonin tubulin folding pathway 21371 66411 108903 73710 72726 22145 53857 22152 545486 227613 238463 22153 22147 56327 22151 22142 70430 22146 22143 67951 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 96%5686938 Regulation of TLR by endogenous ligand 17087 12491 21899 20193 12475 69146 238055 14161 54722 434174 170743 21898 24088 21897 20201 110135 20202 99571 16803 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME%R-HSA-8941413.2 Events associated with phagocytolytic activity of PMN cells 76113 17523 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME DATABASE ID RELEASE 96%1592389 Activation of Matrix Metalloproteinases 13038 17395 17228 13039 17392 17386 17394 17384 17388 23948 50701 17229 83995 72902 18550 240047 22072 17391 66473 17390 21858 21857 18815 12822 17385 17387 16621 17389 17393 13035 INDUCTION OF CELL-CELL FUSION%REACTOME%R-HSA-9733458.3 Induction of Cell-Cell Fusion 18550 102566 404545 320091 243634 101772 50528 70008 105722 382014 233246 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654710 PI-3K cascade:FGFR3 327826 14172 80857 14180 64654 14175 14388 14173 14164 80903 18708 19247 18706 TRANSLESION SYNTHESIS BY REV1%REACTOME DATABASE ID RELEASE 96%110312 Translesion synthesis by REV1 68275 106344 72151 68240 19891 19687 19718 69263 19714 71890 56210 667035 22190 18538 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.3 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) 11998 12000 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.3 The phototransduction cascade 14919 18108 107477 14913 245650 73582 14685 20215 12788 214111 212541 14699 18761 75624 14688 110606 640703 14272 24013 56307 237178 243923 225600 18750 18107 18587 18588 19674 APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%180689 APOBEC3G mediated resistance to HIV-1 infection 23825 268373 15361 101739 ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 96%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate 15926 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME DATABASE ID RELEASE 96%111459 Activation of caspases through apoptosome-mediated cleavage 12367 670717 11783 12371 11798 12369 EGFR DOWNREGULATION%REACTOME%R-HSA-182971.8 EGFR downregulation 58194 20408 12402 56324 24063 24064 19272 12223 15239 20404 71920 13874 20844 20405 15200 13858 19248 667035 22190 13854 54126 13649 21802 13859 11839 13645 SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 96%8985586 SLIT2:ROBO1 increases RHOA activity 19876 11848 20563 17925 VLDL CLEARANCE%REACTOME%R-HSA-8964046.2 VLDL clearance 171504 11812 22359 238055 11425 54135 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME%R-HSA-204998.3 Cell death signalling via NRAGE, NRIF and NADE 102098 20663 12367 22324 277360 667035 22190 18049 22325 622434 545156 16443 12015 57257 19164 20662 17207 19165 12366 100042305 16800 208117 59287 100039623 13605 12070 109904 230972 213498 207212 71704 234094 223435 56349 16801 94275 19418 75547 19353 18053 72754 18412 69632 213649 24001 224014 56321 230098 53972 30938 77669 22034 442801 226970 54126 101497 67733 269608 328967 14163 26382 268739 26419 14674 73341 21844 22627 12125 236915 109934 COMPLEX I BIOGENESIS%REACTOME%R-HSA-6799198.5 Complex I biogenesis 66690 76826 69702 67264 208501 54405 17991 66091 69487 108755 239760 66414 68472 104130 75597 66928 624814 68493 76947 26940 100900 67273 68198 66495 67130 68202 66416 68375 66108 68342 66377 68197 227197 67184 100042503 66046 230075 66916 66218 69089 70316 17721 17722 17716 17717 17718 17719 229211 225887 72900 226646 17995 595136 623286 66706 235169 78330 66349 76916 75406 15526 73694 94281 66271 HEME ASSIMILATION%REACTOME DATABASE ID RELEASE 96%9927020 Heme assimilation 15129 15122 MPS IX - NATOWICZ SYNDROME (HYALURONAN METABOLISM)%REACTOME%R-HSA-2206280.5 MPS IX - Natowicz syndrome (Hyaluronan metabolism) 15586 DECTIN-2 FAMILY%REACTOME%R-HSA-5621480.5 Dectin-2 family 56619 269328 353328 26888 14127 381809 17312 234779 56620 17474 17096 17829 100039649 20963 140474 224116 17063 14360 73732 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME%R-HSA-5205685.9 PINK1-PRKN Mediated Mitophagy 56480 67443 71648 67526 11793 66734 18412 66105 245860 667035 100041766 22190 66410 93765 22334 66589 22333 22335 66169 28185 100043869 53333 66119 22195 67414 50873 170731 223696 68943 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 96%73762 RNA Polymerase I Transcription Initiation 216848 319955 106298 110147 667501 107932 21374 21429 20019 21340 21339 21341 64424 22130 13871 75316 66420 70333 69833 66136 245841 20017 19646 234366 116871 14885 209357 66467 116870 20018 66671 17749 245688 100043714 14534 20016 17420 12572 18519 13872 23894 14884 23942 17192 433759 15182 229542 RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.2 RUNX2 regulates osteoblast differentiation 11350 12842 15213 12400 225207 15214 22601 11835 212712 19645 20779 14634 22612 15205 15185 97064 68527 170574 17132 15183 26413 26417 PRIMITIVE STREAK FORMATION%REACTOME%R-HSA-9754189.5 Primitive streak formation 14106 12387 21414 12159 13813 20997 14836 27217 94093 20674 16842 17126 17127 17128 227606 18999 100038891 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.3 Signaling by FGFR4 in disease 327826 15461 18803 18708 14186 18176 14388 18706 20662 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.6 Neurexins and neuroligins 13823 14811 14810 23859 14814 14813 192167 54525 20910 57267 228836 226352 242667 56376 171180 216856 58234 13385 26558 26557 216028 53310 74342 26556 243961 217692 107065 13169 380785 106025 13822 14816 269587 224997 108071 245537 18189 18190 11784 22343 54526 60510 14812 108030 20980 12361 20979 20907 319924 22342 TIGHT JUNCTION INTERACTIONS%REACTOME DATABASE ID RELEASE 96%420029 Tight junction interactions 56863 12737 75677 16456 53624 93742 56513 12739 12740 56492 18759 621628 56173 242653 239931 58220 18417 114141 12695 224912 64945 56217 12741 71908 60363 54420 58187 54419 12738 93737 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME DATABASE ID RELEASE 96%450531 Regulation of mRNA stability by proteins that bind AU-rich elements 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 11651 26444 19170 66413 238799 193740 667035 26416 22190 22695 59029 67089 70247 19094 15507 54401 18753 17164 15568 11737 69583 671392 66362 227720 109075 66583 27998 72544 50911 69639 24127 72662 66446 227715 74108 70640 75901 103573 12192 15481 208643 22631 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 18750 26442 69077 66997 23997 18458 BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME DATABASE ID RELEASE 96%111453 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members 20848 12122 12043 12048 12015 12125 171543 LOSS OF FUNCTION OF TP53 IN CANCER%REACTOME%R-HSA-9723907.3 Loss of Function of TP53 in Cancer 22059 NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 96%9026357 NTF4 activates NTRK2 (TRKB) signaling 18212 78405 ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.3 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 74769 18707 13856 13857 30955 320207 18708 384783 16452 17096 14388 18706 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME%R-HSA-9664422.2 FCGR3A-mediated phagocytosis 17913 246256 17973 17909 105855 242687 330319 76884 22612 11308 22324 17886 108100 12928 11461 101314 26413 26417 14360 22325 11350 12502 57257 140579 17096 330662 11465 15162 140580 20430 17918 76709 19353 73178 20963 12229 56443 80987 68089 67771 11867 56378 66713 74117 245880 14191 14083 22376 215280 68524 50884 17925 83767 17882 329165 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 96%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) 100929 68260 329504 76357 209584 68736 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.2 Erythropoietin activates RAS 22324 15461 13856 13857 107746 12929 384783 16452 17096 18176 20662 20416 DEFECTIVE AMN CAUSES MGA1%REACTOME%R-HSA-3359462.4 Defective AMN causes MGA1 93835 14603 65969 DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME DATABASE ID RELEASE 96%5619111 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) 20516 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.5 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 18970 11792 RAF ACTIVATION%REACTOME%R-HSA-5673000.4 RAF activation 16706 225849 26931 17532 21770 26932 56392 20779 12322 109880 12323 108058 19046 12325 640703 19047 17169 54401 73699 26395 26396 18176 15461 110157 19052 19053 51792 11836 26403 72399 18673 16452 226849 REGULATION OF EXPRESSION AND FUNCTION OF TYPE II CLASSICAL CADHERINS%REACTOME DATABASE ID RELEASE 96%9764260 Regulation of Expression and Function of Type II Classical Cadherins 12385 233833 59058 110751 20665 12564 15426 24136 12388 16201 12387 236511 20613 20683 12552 57875 15227 213988 217351 214150 230738 227485 17454 56198 16480 76850 77630 239528 11492 239096 DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME%R-HSA-9652282.4 Drug-mediated inhibition of ERBB2 signaling 13866 59079 12539 15519 SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 96%111463 SMAC (DIABLO) binds to IAPs 12367 670717 11783 66593 12371 11798 12369 INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 96%9020956 Interleukin-27 signaling 20848 54721 16451 50498 12330 12931 16452 20846 50931 246779 16195 DEFECTIVE GALNT12 CAUSES CRCS1%REACTOME DATABASE ID RELEASE 96%5083636 Defective GALNT12 causes CRCS1 100039649 140474 224116 269328 353328 230145 17063 73732 17829 DAP12 INTERACTIONS%REACTOME%R-HSA-2172127.3 DAP12 interactions 74769 23845 58217 234779 15006 19353 20963 667803 12229 668101 14360 217304 22325 217306 16643 83433 57257 18176 20662 22177 15461 620235 17444 18803 16818 12010 18708 16822 18709 27007 18706 ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME%R-HSA-1300645.4 Acrosome Reaction and Sperm:Oocyte Membrane Binding 11434 71564 73456 12527 75510 SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME DATABASE ID RELEASE 96%480985 Synthesis of dolichyl-phosphate-glucose 66248 66174 VLDL ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8866423 VLDL assembly 17777 11812 238055 11425 18453 ABC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619084.7 ABC transporter disorders 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 16514 26443 26444 12780 19170 269523 66413 667035 22190 59029 67089 70247 20927 20928 12638 244373 226144 193670 54197 11806 70377 216440 11303 74591 27413 27421 19300 66753 67819 116891 20338 74104 21762 22123 18670 68421 67470 19179 27409 19181 11666 27410 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 FRS2-MEDIATED ACTIVATION%REACTOME DATABASE ID RELEASE 96%170968 Frs2-mediated activation 327826 109905 107746 109880 12929 54401 18049 26395 26396 26413 26417 RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%8941855 RUNX3 regulates CDKN1A transcription 21803 12575 11906 22059 12399 17127 17128 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME%R-HSA-69613.5 p53-Independent G1 S DNA Damage Checkpoint 12234 93687 56436 208583 17463 57296 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 26416 22190 59029 67089 103583 70247 19094 12795 50883 56637 21762 22123 19179 19181 12649 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 12530 23997 27373 CDC42 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013148 CDC42 GTPase cycle 214230 330319 12389 241656 22325 57257 29875 52666 217866 105782 14269 22379 13605 214459 66871 236920 26403 226751 13830 76088 16480 18708 18709 18479 213498 243362 234094 98386 50768 18481 404710 19418 208846 69632 213649 224014 53972 30938 66508 442801 226970 54126 101497 14163 26382 14674 73341 21844 210293 71709 22042 236915 109934 106952 233071 26934 75974 110279 12549 56513 216963 192652 239027 212285 71409 70497 244867 22319 20619 192192 11855 319899 277360 260409 192662 57778 263406 11857 226823 14570 108100 216445 19349 69710 18805 26431 70584 68428 216831 56418 70719 71302 71544 229658 101240 544963 622434 66251 78816 72729 104252 16443 231532 14218 71972 225358 17207 214137 171207 94190 16709 77038 218581 58804 21917 56699 224105 109904 230972 223254 102075 56419 104445 19765 259302 223666 14270 223435 117600 330914 232906 71435 228359 213783 100038946 545481 23853 73178 219140 226652 78514 22376 215280 68524 17925 67299 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.6 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer 328572 12843 20602 20683 211586 17283 21781 22284 228839 83814 18550 11545 16477 66105 667035 97064 22190 107951 93836 26413 18787 20185 26417 67821 12579 22608 12454 13559 20482 104394 20481 51813 17869 94093 19042 17126 17127 12455 17128 72949 66313 433759 216080 17131 19650 21815 264064 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%194002 Glucocorticoid biosynthesis 18976 15484 110115 15483 12401 13072 15492 13074 15497 13079 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME%R-HSA-5635851.3 GLI proteins bind promoters of Hh responsive genes to promote transcription 14632 14634 14633 REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME DATABASE ID RELEASE 96%170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 103988 103468 19386 231103 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 DEUBIQUITINATION%REACTOME%R-HSA-5688426.5 Deubiquitination 15161 75302 68837 56208 12534 22223 50933 17425 71599 228790 56324 15239 20844 269523 12005 101206 17869 15925 15251 12638 84585 100683 218214 109689 12006 216869 328572 101565 14462 216185 21812 21813 18002 28185 100043869 14534 71586 230073 71956 228607 217069 11789 12530 11848 11555 100756 53376 19211 170711 11461 54644 70527 74270 76630 71472 66124 104416 83563 22059 66889 74112 30941 216825 229603 414084 22258 74256 21929 50873 19766 54198 11797 22230 14232 246103 22030 69641 18970 108155 11796 59040 71954 18519 21803 170822 235323 74996 67561 319651 22632 224836 14479 360216 216799 107260 56207 84092 72607 68031 110616 73162 21951 74493 22217 68149 27401 170707 235441 22334 22333 57783 22335 226418 109359 217057 327799 17125 17126 17127 17128 66313 17131 76800 70675 17248 30940 12428 17246 22225 22284 320713 56456 22224 107995 56505 68350 225280 56249 77125 69714 227195 109275 68142 233875 70020 19358 19359 235134 12427 107986 21762 22123 108645 19179 19181 19182 23996 19184 19671 436004 26440 19166 18035 19167 26441 26442 69077 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 16151 19170 192656 66413 667035 22190 59029 26409 67089 24110 68251 257632 20184 70247 269582 70681 107607 13982 231130 107976 210766 11835 59025 621893 319162 15267 319173 319163 319168 319167 319186 319178 12021 319183 319182 54601 319190 22031 319176 319181 12189 66513 22034 50868 252870 319169 78303 319188 216080 319189 20439 382522 110962 G-PROTEIN MEDIATED EVENTS%REACTOME%R-HSA-112040.3 G-protein mediated events 18796 18797 18795 12326 14675 19087 19084 12322 12323 108058 12325 26413 229709 16438 16439 18798 18747 14672 100039592 14676 16440 18753 18783 110355 18575 18574 18573 14682 14680 19088 55984 19108 104110 14678 14677 14679 432530 210044 104111 640703 224129 11512 11513 11514 11515 18749 207565 18752 18750 242851 19085 MPS II - HUNTER SYNDROME (CS DS DEGRADATION)%REACTOME DATABASE ID RELEASE 96%9953078 MPS II - Hunter syndrome (CS DS degradation) 15931 FORMATION OF THE NEPHRIC DUCT%REACTOME DATABASE ID RELEASE 96%9830364 Formation of the nephric duct 279653 12387 19713 12159 15412 16869 18504 14462 67701 114249 14173 13797 15403 15904 231507 14013 18510 23967 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME DATABASE ID RELEASE 96%4551638 SUMOylation of chromatin organization proteins 216848 20230 52615 12419 56469 19386 20610 208727 12418 22196 100043429 170762 108989 231042 227699 214669 223921 227720 445007 269113 12151 66679 22658 18141 107939 19763 69482 71805 54383 54563 13619 19069 70699 241915 72787 12416 18226 218210 19821 69912 103468 212712 234865 30951 59015 69736 110379 433759 15182 MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 96%5223345 Miscellaneous transport and binding events 19743 13829 18716 58176 56315 70701 212555 11519 236792 12007 100604 214112 433926 241296 83429 233280 72267 380836 74552 11732 27360 67075 93790 11518 231549 80286 223473 AUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9612973 Autophagy 93739 22241 56208 67443 78610 21821 74244 269523 66105 107305 72543 22334 22333 194309 18541 52348 15499 22335 15519 73711 22088 13001 67123 13000 234663 330192 100039026 66914 12638 19752 14580 11520 68097 26369 16784 57320 108099 218978 15516 15129 52639 56455 666468 77040 18412 73683 213948 66840 228361 51897 64930 57436 235040 12421 66508 68118 545987 54636 242557 15481 66795 66169 67841 54170 66615 28185 100043869 74781 22084 52187 68576 66096 235661 83409 74370 68441 268706 53333 245670 66119 13427 13426 223696 13424 75669 68943 56480 225326 67526 11793 68146 100756 66734 72018 17966 19305 245860 667035 22190 66371 68953 75608 22195 50873 208092 66700 241113 56717 71648 11920 105513 15185 100041766 66905 66410 93765 66589 13819 97287 105787 108079 19079 74302 108097 56486 67414 19082 56716 170731 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 96%5654743 Signaling by FGFR4 14172 80857 14170 14180 12402 14177 24064 64654 17346 14175 14173 14164 83379 109880 667035 22190 19247 26413 26417 327826 18176 14388 20662 15461 19052 107971 19053 51792 18803 80903 18708 14186 18706 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 96%5357769 Caspase activation via extrinsic apoptotic signalling pathway 14103 17087 22030 72993 12475 13144 21933 13176 69635 13143 225471 107449 12371 106759 94275 107448 14102 12367 21898 71609 14082 22035 12370 19766 MPS IV - MORQUIO SYNDROME B (KERATIN METABOLISM)%REACTOME%R-HSA-2206308.5 MPS IV - Morquio syndrome B (Keratin metabolism) 12091 ORGANIC ANION TRANSPORT BY SLC5 17 25 TRANSPORTERS%REACTOME DATABASE ID RELEASE 96%428643 Organic anion transport by SLC5 17 25 transporters 27376 235504 241612 13358 67863 216225 GSD II%REACTOME%R-HSA-5357609.5 GSD II 27357 14387 NUCLEAR EVENTS MEDIATED BY NFE2L2%REACTOME%R-HSA-9759194.4 Nuclear events mediated by NFE2L2 14381 12234 56436 17463 57296 20422 26445 26446 20683 19172 19173 21881 19175 17250 19697 19177 18128 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 110208 70247 17869 50493 22166 20657 14630 76408 328572 15368 12013 11911 20293 76650 17436 17135 17134 18412 27407 56637 18104 18024 14859 71389 12578 12914 14629 26357 50868 26570 21762 22123 108079 19179 19181 19182 23996 15926 21351 19184 18033 26440 18477 19166 11839 12043 19167 18590 13645 26441 12048 26442 69077 66997 23997 REGULATION OF IFNA IFNB SIGNALING%REACTOME DATABASE ID RELEASE 96%912694 Regulation of IFNA IFNB signaling 54721 16451 15170 20847 15977 19246 19247 12703 12702 24110 15975 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 96%2129379 Molecules associated with elastic fibres 16998 320910 12159 108075 16420 241226 12154 16419 17150 216760 76293 14115 14114 12162 50530 23876 216616 12156 58859 16412 14563 16410 16416 21803 21808 22370 21809 268977 16997 CARNITINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%71262 Carnitine synthesis 170442 192289 56752 20425 PTEN LOSS OF FUNCTION IN CANCER%REACTOME DATABASE ID RELEASE 96%5674404 PTEN Loss of Function in Cancer 19211 INTERLEUKIN-38 SIGNALING%REACTOME%R-HSA-9007892.3 Interleukin-38 signaling 107527 26419 215274 331461 NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 96%5674499 Negative feedback regulation of MAPK pathway 110157 109880 26395 26396 26413 26417 RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.7 RNA Polymerase II Transcription Termination 384091 666609 68092 433702 20638 243963 67332 20492 72290 116748 68219 98985 228410 54451 108062 67337 54196 83410 18789 51786 94230 74320 68188 54188 66899 269061 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190322.3 FGFR4 ligand binding and activation 83379 14172 80857 14170 14180 14177 80903 64654 14175 14186 14173 14164 OXIDATIVE DEMETHYLATION OF DNA%REACTOME%R-HSA-5221030.6 Oxidative demethylation of DNA 52463 194388 214133 REGULATION OF CDH1 GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 96%9764560 Regulation of CDH1 Gene Transcription 232440 24136 13626 20683 319149 15376 20586 19645 22431 21423 15077 13345 75339 192173 20901 21417 52615 60611 16601 18746 19646 114142 26413 76007 26417 56805 21418 21406 21885 245688 15267 319168 319167 22160 319186 16600 319178 319183 319182 20613 319190 319176 319181 228839 99982 93759 228913 20583 14056 93760 319169 67956 625328 78303 319188 15270 433759 13017 13016 15220 15182 624153 382522 LXR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%9024446 LXR-mediated signaling 328572 233833 30924 20602 14104 236511 21372 17977 11307 22259 11816 11303 213988 81004 20249 217351 214150 103968 56310 218203 268903 99982 15183 16204 20185 22260 20181 20182 17454 11812 11813 11425 67470 27409 67484 218214 11815 320982 230674 104263 22236 76850 239528 18534 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.7 Regulation of ornithine decarboxylase (ODC) 56436 17463 57296 54375 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 18104 59029 67089 70247 18247 18245 18263 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 53814 23997 AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.4 Axonal growth inhibition (RHOA activation) 18053 11848 192662 109904 17136 68585 18377 235402 DISEASES OF THE NEURONAL SYSTEM%REACTOME%R-HSA-9675143.3 Diseases of the neuronal system 242864 77974 79235 14539 19659 12057 22139 19682 11304 19771 20897 19662 NICOTINATE METABOLISM%REACTOME%R-HSA-196807.8 Nicotinate metabolism 12182 59027 216225 67375 246703 225994 74080 68646 78914 69564 230125 102570 223646 66454 192185 214424 328417 67287 80285 18113 52552 671535 67993 547253 67795 226518 23959 12494 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME DATABASE ID RELEASE 96%9672387 Defective F8 accelerates dissociation of the A2 domain 14069 RHOU GTPASE CYCLE%REACTOME%R-HSA-9013420.5 RHOU GTPase cycle 13836 17973 12549 14270 216963 56513 18481 56324 20742 66894 20779 15239 22284 83669 20844 226652 19229 26431 244895 71228 70584 20403 54126 229658 73341 69581 29875 17974 218581 67300 17920 224105 18708 18709 53382 18479 20740 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME DATABASE ID RELEASE 96%77289 Mitochondrial Fatty Acid Beta-Oxidation 171281 74156 13167 223722 329910 70316 11370 11364 67460 11409 13177 93747 15107 20216 18559 66198 264895 110821 66904 17850 73724 109136 66834 97212 11363 231086 26922 171210 70025 71985 52538 72482 78245 102632 75778 56360 NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.4 NADE modulates death signalling 12366 12367 18053 12070 22627 18049 DNA REPAIR%REACTOME%R-HSA-73894.5 DNA Repair 232440 74153 20892 70620 17193 269523 234258 71726 382913 18294 72774 18207 66983 240087 71101 71991 12848 26430 100206 100043806 26891 19822 59047 26370 56031 21399 68098 140917 272158 330554 55947 217069 57905 13716 17314 231642 208836 56438 67439 11461 19060 55982 104416 51869 22059 56626 225896 14051 56196 108138 93762 217365 22385 11834 11785 75570 104884 319583 67196 230674 227525 54125 14050 14049 14048 77782 22230 18970 11792 22594 16882 93836 28000 193796 99375 22210 72584 58186 230484 13194 67561 22632 76843 100038882 12566 11545 16881 11350 100039592 50721 28113 101185 12428 319955 57321 56456 22224 19714 244666 71890 26447 319152 56210 77593 68026 56505 216835 68058 21749 225280 497652 26893 21750 56249 69714 227195 109275 26894 68142 11546 13870 108679 233875 70020 19358 19359 235134 26419 22590 12427 22591 107986 26572 22592 50505 26895 268395 69928 18861 17685 268420 17686 69113 17350 69090 17688 75452 20422 77987 26383 14156 667035 13871 22190 66420 69833 67710 245841 69920 107823 20022 68251 14885 20184 209357 66131 66467 269582 20020 232314 231329 70681 20021 70238 69241 27223 56469 66671 19365 17749 56420 100043714 107976 210766 17420 21853 12572 59004 13872 20610 23894 14884 22196 100043429 15267 15204 229615 319168 319167 52864 19360 27015 69745 17535 21975 19363 319186 19364 27354 319178 12021 319183 224008 319182 60530 56791 67513 81601 50883 67030 327762 269400 59001 319190 19361 26754 114714 209334 22427 19687 101831 19090 19718 319176 69263 15574 11920 319181 104806 66979 12189 12190 235610 231724 237911 22596 19355 57434 71885 14375 225182 74335 93765 26909 14087 18538 235559 71711 12144 100040608 381306 237211 68275 106344 72775 72151 211651 18971 14088 68240 60534 18972 233826 252870 19891 18973 319169 18974 80905 19367 19356 19362 67967 268465 12649 78303 319188 15270 624153 382522 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 96%5578997 Defective AHCY causes HMAHCHD 269378 MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%390648 Muscarinic acetylcholine receptors 12672 12671 213788 243764 12669 SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.6 Signaling by ERBB4 11491 18183 83961 20779 100042150 11816 667035 22190 20203 17999 20416 107568 13982 13385 13649 22601 18176 14580 19164 20662 19165 15461 100042305 208117 59287 17122 100039623 231821 18667 16396 18708 16765 18706 12991 12223 13874 20850 15200 211323 14402 14401 14400 20185 14394 68652 80707 14407 14406 57249 20692 20315 13645 BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME%R-HSA-77310.3 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 15107 97212 11363 231086 93747 NEUROTRANSMITTER CLEARANCE%REACTOME DATABASE ID RELEASE 96%112311 Neurotransmitter clearance 11423 20518 20517 17161 11669 12846 13162 12038 791260 15567 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 96%3247509 Chromatin modifying enzymes 15161 21427 109115 66233 58523 232440 269424 78656 20602 13626 73247 319149 225895 74026 67155 77766 20586 54351 74195 20588 72341 217031 20587 107435 226976 230233 208146 76804 77853 21761 15077 76901 76719 17692 66310 102162 223527 140858 56790 382207 56397 72195 69612 52615 28019 101206 27878 19646 71777 13486 234366 213464 217127 217588 108946 214162 75565 228714 67773 245688 23808 23942 100683 218214 104263 16452 328572 21372 231051 239985 18600 17977 17978 59035 81004 216185 66993 108143 66464 56310 12753 208043 15183 20185 12914 11909 214899 14534 18599 22289 242726 18602 18601 216848 30841 225876 277250 20174 20591 18676 320595 20592 107932 244694 71371 170787 11461 75605 13435 19712 216825 68094 83796 83797 57376 230674 268936 229542 246103 108155 50724 60406 226830 70315 99982 217864 94246 193796 244349 100041953 71954 107392 667279 238247 15353 18519 77044 12567 12443 269003 233904 83766 75410 69726 208266 232811 239122 54343 11569 213389 17192 66083 77683 52690 18193 14013 20937 192195 75560 93871 73251 225888 64707 84505 234135 235626 70088 110147 56456 56505 99890 216850 93760 66923 67956 18033 64050 381022 19697 107817 27374 70465 107823 67014 71974 621893 214572 319162 15267 319173 319163 319168 66423 319167 13831 319186 319178 319183 319182 81601 228829 319190 338523 319176 18034 319181 66262 70673 116871 116870 78783 14056 319169 15469 18505 78303 319188 15270 433759 319189 624153 15182 382522 SENSORY PERCEPTION OF SOUR TASTE%REACTOME DATABASE ID RELEASE 96%9729555 Sensory perception of sour taste 16518 21906 BIOSYNTHESIS OF PROTECTINS%REACTOME%R-HSA-9018681.2 Biosynthesis of protectins 16993 11687 13077 13076 CTNNB1 S33 MUTANTS AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358747.4 CTNNB1 S33 mutants aren't phosphorylated 225849 93687 26931 21770 26932 12387 73699 72345 19052 19053 51792 56637 12005 11789 226849 REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.3 Regulation of KIT signaling 16923 15170 23921 12402 17096 22612 20662 16590 16818 18750 12703 14360 54607 VARIANT SLC6A20 AFFECTING NEUROTRANSMITTER TRANSPORT CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.5 Variant SLC6A20 affecting neurotransmitter transport contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) 102680 FANCONI ANEMIA PATHWAY%REACTOME%R-HSA-6783310.6 Fanconi Anemia Pathway 67513 67030 208836 20892 101831 104806 235610 667035 71885 22190 14087 71711 100040608 237211 13870 68275 72775 211651 14088 140917 272158 60534 68240 330554 55947 19891 50505 268465 69928 67196 52864 230484 67561 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.5 Cyclin E associated events during G1 S transition 54124 56436 20459 17463 17187 75660 57296 20422 26445 26446 12575 19172 19173 211586 19175 13555 19645 19177 21781 21402 12567 26443 12443 11651 26444 12566 11652 19170 12447 66413 26965 667035 27401 22190 12448 59029 12576 19646 67089 70247 66671 17869 17420 12572 12428 13559 104394 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 19651 26441 63955 22390 26442 72568 69077 23797 66997 12530 231506 23997 629959 3-METHYLGLUTACONIC ACIDURIA%REACTOME DATABASE ID RELEASE 96%9914274 3-methylglutaconic aciduria 11992 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 96%5578998 Defective OPLAH causes OPLAHD 75475 SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855191 Synthesis of IPs in the nucleus 75678 27399 76500 69718 DIGESTION OF DIETARY LIPID%REACTOME%R-HSA-192456.7 Digestion of dietary lipid 67717 12613 69060 18946 109791 18947 SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME%R-HSA-2142688.4 Synthesis of 5-eicosatetraenoic acids 17001 14775 625249 11690 14776 18979 11689 330260 269823 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 96%173623 Classical antibody-mediated complement activation 317677 12944 12259 12260 12262 667277 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.7 Detoxification of Reactive Oxygen Species 66401 670717 14780 14778 14775 26462 67305 12460 11833 17969 11927 69590 18453 50527 50490 13058 75512 14776 56551 13057 11758 11757 17970 17972 667310 11977 20656 50493 18477 21672 22166 12359 20657 G1 PHASE%REACTOME DATABASE ID RELEASE 96%69236 G1 Phase 54124 20459 12575 211586 13555 19645 21781 21402 12571 12567 12443 12566 12444 12445 13557 12447 242705 26965 667035 27401 22190 12448 12577 12576 100043858 12580 12579 12578 11350 13559 104394 66671 17420 73699 12572 71978 17096 19052 19053 51792 19650 19651 16452 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME%R-HSA-5619048.3 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) 18174 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 96%5579016 Defective UGT1A4 causes hyperbilirubinemia 394433 NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 96%199418 Negative regulation of the PI3K AKT network 268980 18183 83961 320207 100042150 20779 17295 11651 11652 22324 18710 14255 26413 26417 14360 327826 13649 21802 73699 19052 19053 228775 51792 30955 18708 18709 18706 226849 108083 225849 74769 18707 26931 12487 21770 12519 26932 12524 12223 71920 13874 15200 211323 77125 19354 12064 14388 15234 17082 18212 18205 78405 11839 13645 80903 384783 14186 14165 83490 18596 14389 77647 16367 18213 14172 80857 16334 14170 14180 14178 14177 67112 64654 14175 14174 14173 14164 83379 17874 16179 19211 13983 266632 13982 18595 244650 98432 15937 12478 75778 18591 56212 16337 18718 19353 14256 19247 22034 104709 13866 18720 18719 18717 16818 16590 23797 DEFECTIVE TRANSPORT BY SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5619037.4 Defective transport by SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) 24060 PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 96%202427 Phosphorylation of CD3 and TCR zeta chains 12500 16818 19271 12501 12502 19264 14969 12504 14968 12988 94212 19260 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME%R-HSA-9673767.2 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants 20848 74769 15461 18595 18708 18709 18176 20846 18706 20662 ARG1 VARIANTS CAUSE HYPERARGININEMIA%REACTOME DATABASE ID RELEASE 96%9956514 ARG1 variants cause hyperargininemia 11846 EXPRESSION OF NOTCH2NL GENES%REACTOME%R-HSA-9911233.3 Expression of NOTCH2NL genes 50701 HEME DEGRADATION%REACTOME%R-HSA-189483.5 Heme degradation 394433 12780 15368 14080 26357 17250 15369 11657 109778 233016 28253 394436 METABOLISM OF STEROID HORMONES%REACTOME%R-HSA-196071.5 Metabolism of steroid hormones 110115 94224 13072 13074 15492 78925 15497 13079 16866 15487 100042622 15486 76205 66065 59045 114664 12257 14187 170459 20845 15484 15483 12401 12640 13075 13070 56348 57357 68165 14149 14148 15485 18976 11677 SENSORY PERCEPTION OF SWEET, BITTER, AND UMAMI (GLUTAMATE) TASTE%REACTOME DATABASE ID RELEASE 96%9717207 Sensory perception of sweet, bitter, and umami (glutamate) taste 18796 20266 546729 387513 399548 20274 110876 20269 72821 387353 240669 387515 353148 68667 14688 353165 387348 14695 268934 16440 56843 64337 83771 574417 14816 387347 57253 57254 110326 387355 83770 387342 387349 242851 387616 SIGNALING BY NOTCH1 IN CANCER%REACTOME%R-HSA-2644603.5 Signaling by NOTCH1 in Cancer 18011 232232 13388 16449 240055 225164 20602 11487 54485 11491 16450 18128 21402 56438 79221 270118 170787 26965 667035 22190 15213 56233 17869 15214 208727 19164 19165 15208 100042305 208117 59287 100039623 56198 76580 264064 103806 328572 21372 333639 81004 15185 70315 15184 15183 20185 12914 51813 14534 18519 15205 19664 433759 15182 DUAL INCISION IN TC-NER%REACTOME%R-HSA-6782135.4 Dual incision in TC-NER 56438 667035 13871 22190 66420 67439 69833 67710 245841 69920 20022 14885 66983 209357 71101 66467 71991 20020 231329 20021 69241 66671 17749 100043714 17420 12572 13872 23894 14884 11834 27015 69745 59001 319955 19687 19718 69263 66979 56031 21399 18538 28000 13870 68275 106344 72151 18971 68240 18972 252870 22590 19891 18973 18974 22592 50505 67967 57905 99375 72584 13194 REPRODUCTION%REACTOME DATABASE ID RELEASE 96%1474165 Reproduction 232440 12767 319149 14595 12567 12566 15077 94244 21420 12527 20842 22787 329954 71078 213389 28113 11434 22788 101185 22786 16532 106757 225865 24061 74096 73456 12659 320225 56622 76856 19357 75510 11495 212670 271036 71564 12159 57321 319152 21749 497652 21750 244551 12396 13006 18999 100038891 16906 20843 17350 13404 26972 19183 74468 217716 76915 55993 17687 14726 22196 15267 319168 319167 19360 17535 21975 319186 15512 27354 319178 319183 319182 60530 319190 13813 19361 20671 114714 319176 223697 11920 319181 12189 12190 225182 12142 214133 12144 381306 68275 68240 19891 319169 625328 56739 78303 140557 319188 50878 15270 20962 74075 320558 64009 319565 71846 624153 66654 20957 75459 77053 382522 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8941858 Regulation of RUNX3 expression and activity 328572 56436 17463 57296 12400 20422 26445 26446 17246 19172 19173 19175 19177 20779 12399 26443 26444 19170 66413 667035 22190 59029 67089 70247 12578 21762 22123 19179 19181 21803 19182 23996 19184 75788 66313 26440 19166 19167 26441 26442 69077 66997 23997 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 96%198745 Signalling to STAT3 20848 18211 18049 SELENOCYSTEINE SYNTHESIS%REACTOME DATABASE ID RELEASE 96%2408557 Selenocysteine synthesis 622534 238217 16785 666669 100040021 67025 100043391 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 667035 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 214580 20768 57294 211006 20226 65967 75420 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 65019 629957 20102 20103 668668 667739 672214 66481 225058 100038875 100038991 68028 100043000 67891 100043295 ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME%R-HSA-442380.4 Zinc influx into cells by the SLC39 gene family 213053 214922 227059 30791 106947 72027 14977 106957 67547 72002 SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 96%6802948 Signaling by high-kinase activity BRAF mutants 16706 20779 109880 26413 26417 12988 109905 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 11836 109689 216869 110135 99571 22330 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.6 ER to Golgi Anterograde Transport 193813 12068 54160 317717 56494 60409 89867 11733 235416 11735 216131 107338 67231 66111 640524 66890 20742 20741 54399 20743 217615 338366 80297 234663 224139 21802 213827 11844 53334 68097 67511 53598 56358 14799 56444 67665 104318 22428 56455 13191 12344 59288 105785 11840 64138 235661 18195 108123 108124 76332 16834 110379 11839 13427 102339 13426 13424 99412 338337 17957 67542 16334 66397 97484 69608 233824 218811 99683 56418 70361 77371 20334 66251 56447 54161 77038 12836 56389 59042 56395 69654 228998 68137 67091 20703 11843 66226 19324 66913 105522 243819 14067 69162 14275 12793 12343 67857 12345 100042773 20333 11842 215474 207352 74498 66682 12340 50797 52036 76983 13032 70349 245828 12847 12794 54130 240667 67727 214895 59005 14069 78232 56041 333883 21787 27096 72978 227648 76308 76510 20739 100042343 20740 50907 LGK974 INHIBITS PORCN%REACTOME%R-HSA-5340573.4 LGK974 inhibits PORCN 53627 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME%R-HSA-5632987.2 Defective Mismatch Repair Associated With PMS2 17350 18861 PROSTANOID LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%391908 Prostanoid ligand receptors 19216 19220 19218 19219 19214 21390 19222 14764 19217 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 96%379401 Clearance of dopamine 17161 12846 13162 791260 ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME DATABASE ID RELEASE 96%68867 Assembly of the pre-replicative complex 52717 56436 99152 17463 668450 67177 57296 23834 20422 232440 26445 26446 57441 19172 319149 19173 19175 16650 19177 26443 26444 19170 15077 66413 56371 667035 22190 59029 67089 70247 16211 15267 319168 319167 319186 319178 319183 319182 319190 17216 16646 17215 17217 17218 319176 17219 17220 319181 50793 18392 18393 66634 26428 26429 56452 319169 21762 22123 19179 19181 19182 217232 23996 56317 625328 19184 59008 78303 319188 26440 66156 15270 19166 216080 69957 19167 17222 75430 26441 68612 52563 624153 26442 22194 69077 68999 66997 52206 23997 100039535 382522 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.5 RAF-independent MAPK1 3 activation 16193 16451 12534 70686 26395 26396 75590 235584 54721 67603 18218 319520 63953 13537 19252 240672 19247 16194 26413 18611 16452 26417 DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 96%5619060 Defective CP causes aceruloplasminemia (ACERULOP) 12870 53945 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 96%3296197 Hydroxycarboxylic acid-binding receptors 243270 80885 MDK AND PTN IN ALK SIGNALING%REACTOME%R-HSA-9851151.1 MDK and PTN in ALK signaling 19242 19283 17242 11682 PPARA ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-1989781.6 PPARA activates gene expression 20602 23989 59024 18631 327987 70625 68975 14081 234959 94112 28077 70208 12491 20182 20186 171285 13122 11520 56771 50493 228775 80509 67224 19014 229003 11655 11865 66999 328572 11606 394434 21372 11624 109151 11622 11806 17977 73690 19017 18143 13076 17436 17978 59035 81004 66993 24001 69790 56310 12753 26896 15183 20185 217166 107765 12896 12914 56406 108098 76267 14200 18670 15360 66172 170826 192191 14373 26457 78334 94185 14137 100040592 20683 195733 18044 20933 18045 18046 20788 75613 381379 17764 22260 20181 67219 19013 19883 26379 19016 12894 18181 264064 19731 67544 230753 76199 67279 57875 22259 11303 66113 100040843 11807 11364 11863 11864 17979 216154 51813 14080 20859 69792 67381 TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 96%72202 Transport of Mature Transcript to Cytoplasm 386612 17149 100040029 20492 19386 170762 108989 231042 227699 223921 227720 445007 269113 66679 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 64340 622469 69912 225027 67996 13684 225160 51796 56488 103468 192160 331401 71713 53817 233073 625193 69823 234865 54451 20382 110809 73666 60365 20383 59015 51786 68278 69736 94230 170722 74320 70579 68188 21681 73826 54188 68134 110379 66231 66511 66899 107829 108014 53319 192170 69207 19826 193116 74412 66441 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME%R-HSA-196819.4 Vitamin B1 (thiamin) metabolism 105663 116914 29807 67283 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 96%5545483 Defective Mismatch Repair Associated With MLH1 17350 18861 GLYCOSPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9840310.3 Glycosphingolipid catabolism 54447 11881 14466 244757 18010 23956 58911 20597 11605 271970 11886 17113 67902 14667 545260 11883 19025 19156 50877 74008 20598 77041 77626 58994 14420 70893 15212 238011 15211 230101 12091 DEFECTIVE F9 SECRETION%REACTOME%R-HSA-9673218.3 Defective F9 secretion 14071 DEFECTIVE MPI CAUSES CDG-1B%REACTOME%R-HSA-4043916.4 Defective MPI causes CDG-1b 110119 THE CRY:PER:KINASE COMPLEX REPRESSES TRANSACTIVATION BY THE BMAL:CLOCK (ARNTL:CLOCK) COMPLEX%REACTOME DATABASE ID RELEASE 96%9931521 The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex 12952 12914 214162 104318 12753 18626 11865 18627 18143 18628 27373 12953 BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME DATABASE ID RELEASE 96%77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 15107 97212 231086 11364 93747 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975578.5 Reactions specific to the complex N-glycan synthesis pathway 53618 217664 98388 12640 71665 68947 17158 16866 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME DATABASE ID RELEASE 96%9665348 Signaling by ERBB2 ECD mutants 13866 59079 12539 13649 18176 14388 20662 15461 18803 13645 18708 18706 20416 15519 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 96%5627083 RHO GTPases regulate CFTR trafficking 94221 12638 DEFECTIVE MGAT2 CAUSES CDG-2A%REACTOME DATABASE ID RELEASE 96%4793952 Defective MGAT2 causes CDG-2a 217664 GLUCOSE METABOLISM%REACTOME DATABASE ID RELEASE 96%70326 Glucose metabolism 18639 14377 18640 170768 14385 18648 56012 15277 70974 15275 56421 18663 67980 14121 14120 74551 18747 14447 224674 19386 231103 73699 216019 14751 19052 19053 51792 170762 108989 231042 227699 100043349 223921 227720 445007 269113 11674 66679 72141 18141 230163 107939 212032 69482 21770 71805 226265 54563 19069 70699 72787 13806 18226 218210 18563 21991 69912 13808 18655 103988 13807 103468 68401 234865 59015 18749 69736 110379 270198 18641 11676 18642 26384 18534 12183 14378 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 96%428542 Regulation of commissural axon pathfinding by SLIT and ROBO 19876 20563 268902 54003 20564 20562 13176 18208 20779 DEFECTIVE VISUAL PHOTOTRANSDUCTION DUE TO ABCA4 LOSS OF FUNCTION%REACTOME%R-HSA-9918454.1 Defective visual phototransduction due to ABCA4 loss of function 11304 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702577 semaxanib-resistant FLT3 mutants 14255 SARS-COV-1 ACTIVATES MODULATES INNATE IMMUNE RESPONSES%REACTOME DATABASE ID RELEASE 96%9692916 SARS-CoV-1 activates modulates innate immune responses 56532 56480 54131 66824 22031 216799 56489 19697 53902 72512 64685 667035 69550 225913 22190 66101 19035 228005 22034 28185 16211 100039592 268373 20390 71586 230073 66641 108960 18521 14225 228607 217069 12362 18033 170743 18035 16396 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.2 Hedgehog 'on' state 93687 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 19206 66413 667035 22190 59029 67089 70247 68525 16568 59056 74239 104346 230500 20747 110355 20423 66313 109689 216869 16396 13363 319757 240888 14632 66573 71742 76857 214498 16147 26554 14451 57810 15245 21762 117606 22123 14634 18222 14633 19179 19181 19182 23996 19184 75788 26440 19166 19167 24069 26441 26442 69077 66997 23997 PLATELET HOMEOSTASIS%REACTOME DATABASE ID RELEASE 96%418346 Platelet homeostasis 269717 58802 11937 11938 53313 109305 72413 109552 67972 11941 320707 14697 381290 16531 16533 22065 26416 22068 18126 14710 20866 14699 110891 66066 14700 16438 16439 14708 14706 20541 14704 18125 14695 23984 110893 26946 241489 16440 73699 18783 14693 18436 228139 64337 18574 18440 14709 18573 94045 231602 207728 19052 19053 14701 51792 435726 226849 225849 26931 14702 21770 26932 18613 14696 242202 18127 18585 17540 238055 19222 54195 60596 234889 19247 14688 18438 640703 15170 100163 14191 18439 19092 CHYLOMICRON CLEARANCE%REACTOME%R-HSA-8964026.3 Chylomicron clearance 100017 15450 16835 238055 11816 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.5 Transcriptional regulation of white adipocyte differentiation 20602 23989 20933 19697 12567 59024 11450 327987 12445 11819 70625 20788 68975 234959 75613 381379 12224 22410 12606 94112 20181 28077 70208 67219 19013 12491 171285 19016 56771 21926 80509 68910 13591 16846 18139 67224 19014 13654 264064 229003 67544 230753 66999 76199 16600 328572 12609 67279 21372 109151 57875 17977 19017 16956 17978 59035 81004 66993 69790 103968 26896 15183 20185 17979 216154 12914 22408 20528 56406 51813 108098 11770 12608 69792 21803 67381 18033 66172 192191 78334 18534 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME%R-HSA-9663199.3 Defective DNA double strand break response due to BRCA1 loss of function 12021 12189 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME DATABASE ID RELEASE 96%392851 Prostacyclin signalling through prostacyclin receptor 14708 14706 14702 14704 14696 14695 14693 64337 19222 14709 14697 14701 14710 14699 66066 14700 14688 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.4 Toxicity of botulinum toxin type C (botC) 56216 20614 20907 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME%R-HSA-5579009.5 Defective CYP11B2 causes CMO-1 deficiency 13072 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME%R-HSA-1299503.3 TWIK related potassium channel (TREK) 16526 72258 16528 RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.4 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 18970 14156 59001 11792 19687 19718 69263 66979 11545 16881 18538 11546 68275 106344 72151 18971 68240 18972 19891 18973 18974 67967 69745 26430 100206 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME DATABASE ID RELEASE 96%5619097 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) 142681 REGULATION OF CDH1 MRNA TRANSLATION BY MICRORNAS%REACTOME DATABASE ID RELEASE 96%9764562 Regulation of CDH1 mRNA translation by microRNAs 233833 213988 17869 236511 217351 17454 12550 214150 76850 239528 18109 CHROMATIN ORGANIZATION%REACTOME DATABASE ID RELEASE 96%4839726 Chromatin organization 15161 21427 109115 66233 58523 232440 269424 12387 78656 20602 13626 73247 319149 225895 74026 67155 240442 77766 20586 13445 11538 54351 269610 74195 20588 106795 72341 217031 20587 22780 107435 226976 14025 22779 230233 208146 78266 76804 77853 228880 21761 52004 15077 76901 76719 17191 17692 233410 66310 102162 11819 223527 22778 140858 56790 622675 382207 70998 56397 72195 69612 52615 28019 101206 27878 19646 71777 13486 234366 213464 217127 217588 108946 214162 16002 75565 228714 67773 245688 56811 23808 23942 100683 218214 104263 12006 67772 16452 328572 67959 21372 109151 107701 231051 239985 18600 210982 17977 105246 72047 243842 17135 17978 59035 20833 81004 216185 66993 108143 66464 56310 12753 18024 208043 15183 20185 114741 12914 11909 212880 214899 14534 18599 22289 242726 18602 18601 68479 20222 216848 319322 30841 225876 27967 277250 20174 20591 18676 320595 12412 20592 107932 244694 71371 68981 20639 170787 101943 81898 11461 20646 75605 13435 19712 26992 216825 68094 83796 83797 57376 230674 66055 268936 229542 67465 246103 108155 13018 72293 67958 241128 320790 76479 50724 60406 226830 75062 70315 12648 244059 99982 217864 94246 13204 193796 244349 100041953 76938 71954 107392 66125 667279 238247 15353 18519 77044 18534 12567 12443 269003 14121 233904 83766 75410 69726 208266 232811 239122 54343 11569 213389 17192 66083 77683 52690 70802 18193 101631 14013 73503 20937 192195 75560 93871 73251 225888 64707 84505 234135 235626 70088 110147 56456 56505 99890 18104 22026 216850 76246 71389 214498 66317 21413 93760 235497 66923 22083 17927 17928 54624 67956 18033 64050 381022 14377 107686 19697 384091 666609 70127 29861 269397 21423 107817 19708 268996 20641 27374 20638 12055 12054 70465 77045 67332 107823 21406 67014 22196 71974 621893 214572 319162 15267 319173 319163 319168 66423 319167 13831 319186 319178 319183 319182 81601 228829 319190 338523 319176 18034 319181 66262 70673 116871 116870 78783 14056 319169 15469 18505 12417 625328 78303 319188 15270 433759 319189 624153 15182 72057 58208 382522 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME%R-HSA-5619056.4 Defective HK1 causes hexokinase deficiency (HK deficiency) 15275 DEFECTIVE DOLK CAUSES CDG-1M%REACTOME%R-HSA-4755583.4 Defective DOLK causes CDG-1m 227697 EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME DATABASE ID RELEASE 96%3928663 EPHA-mediated growth cone collapse 67268 67938 17904 11848 17880 17096 22612 19877 77579 71960 17886 19878 53972 14360 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9632693.5 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects 12571 12567 12578 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.4 Formation of the Editosome 11810 80287 11811 69865 71281 RIBOSOME QUALITY CONTROL (RQC) COMPLEX EXTRACTS AND DEGRADES NASCENT PEPTIDE%REACTOME%R-HSA-9954709.2 Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide 622534 56436 238217 17463 57296 20422 666669 26445 100040021 26446 67025 19172 100043391 19173 668182 19175 241053 19177 432502 56438 19989 26443 76808 26444 19899 100043184 19170 19921 19934 269523 100043755 66413 667035 22190 319195 100043209 68193 59029 621100 19941 67089 665189 666899 70247 100042670 22121 100043876 100043893 100043423 100042986 67281 625646 217365 68172 100042740 19951 667618 100040970 56040 67248 100040331 78913 22230 66855 66244 76788 52231 100041766 68098 67186 67923 21762 22123 65019 19179 19181 19182 23996 19184 26440 19166 216080 672214 19167 71745 26441 100038991 26442 68028 69077 100043000 66997 67891 23997 100043295 REGULATION OF NPAS4 GENE TRANSCRIPTION%REACTOME%R-HSA-9768777.2 Regulation of NPAS4 gene transcription 20807 19712 14815 56461 CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.8 Cilium Assembly 20873 68121 76260 81896 12534 69940 78887 16570 71769 107338 21821 22628 76411 277939 225745 241950 231123 66482 654470 67590 74360 73242 238799 18536 109181 13196 68259 66296 214552 59030 74201 18541 76568 75786 66061 15519 16568 18747 213081 213575 67161 19889 53869 71909 140810 237222 52028 67378 93730 102774 74025 17997 12879 68097 67978 264134 18005 215445 73738 68475 51792 53598 208518 67694 380718 100041639 67286 236266 20607 78802 106633 244585 12009 99100 103733 319845 22154 74470 104318 56455 101565 110350 16559 16328 219103 18763 18764 260305 76779 16579 83922 71492 245866 216363 26370 76707 13589 18472 232987 21454 12462 13427 22627 13424 27373 12469 12461 12464 64436 18582 227613 68146 22153 22142 212541 22145 12465 100986 319757 12589 19088 56350 77048 230376 69654 52906 17274 18000 73668 67661 75296 53413 75465 15185 72421 72140 106840 67344 67068 219072 11843 20336 56297 225659 107371 72938 53885 207911 76478 320299 329795 78177 16569 217935 27078 28135 214444 76816 74019 217335 54130 105504 74682 211446 72569 18817 71820 381644 102058 109242 67042 233649 73916 12789 382090 232944 231214 MITOCHONDRIAL RIBOSOME-ASSOCIATED QUALITY CONTROL%REACTOME DATABASE ID RELEASE 96%9937383 Mitochondrial ribosome-associated quality control 64658 66419 64660 78523 94061 623346 102060 50529 100040519 68565 99045 66973 69163 52443 69089 66077 68611 94062 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 70316 67681 64655 107733 68537 18100 67707 94066 60441 218506 66230 68463 65111 74600 107734 66242 28028 68735 622268 27398 94067 67840 68836 79044 239555 94065 57312 75398 68572 67308 64659 56282 66292 24030 66121 67851 66163 68499 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 66223 PLC-GAMMA1 SIGNALLING%REACTOME%R-HSA-167021.5 PLC-gamma1 signalling 18211 18803 18049 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 96%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P 21351 SEMAPHORIN INTERACTIONS%REACTOME%R-HSA-373755.3 Semaphorin interactions 11848 14159 18186 17295 77579 18844 71960 20354 20130 109700 16885 16886 223881 17886 14360 15519 67268 227377 16412 19877 21894 243743 19878 224105 18479 213498 15516 67938 17904 232906 18481 11852 67784 17880 65254 19353 20358 69632 12517 56637 20346 19264 235611 20351 12631 13866 18717 26757 83433 18845 11853 20349 140571 20356 22177 18846 22240 54712 12569 12934 20361 12568 12933 214968 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.5 Defective CYP4F22 causes ARCI5 320997 CHYLOMICRON REMODELING%REACTOME%R-HSA-8963901.2 Chylomicron remodeling 66113 68453 11806 11813 11814 238055 11807 11808 11816 16956 NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%112310 Neurotransmitter release cycle 232333 14412 17161 63993 242607 14411 243616 233977 214084 20508 67760 65106 20518 20517 20513 22343 20511 20510 216456 15481 20512 108030 268860 12647 14660 14415 14417 67111 22348 214579 12361 27204 19339 22318 13002 20614 20965 20979 20964 20907 68507 319924 327814 12889 22249 22342 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME%R-HSA-202131.6 Metabolism of nitric oxide: NOS3 activation and regulation 640703 69219 114886 18127 66427 13430 18777 18108 12389 11651 73178 66394 68268 20751 18107 329416 15519 SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.3 Synthesis of IPs in the ER lumen 17330 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.8 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 18796 18797 14672 14682 18795 14676 233081 14675 APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.4 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 52717 56436 99152 17463 668450 57296 12534 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 18005 12428 12237 107995 12427 56150 21762 22123 19179 19181 19182 217232 23996 56317 12236 19184 59008 26440 66156 19166 216080 69957 19167 17222 75430 26441 68612 52563 26442 22194 69077 68999 66997 52206 23997 100039535 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.2 Regorafenib-resistant KIT mutants 16590 MITOCHONDRIAL SHORT-CHAIN ENOYL-COA HYDRATASE DEFICIENCY 1%REACTOME%R-HSA-9916720.1 Mitochondrial short-chain enoyl-CoA hydratase deficiency 1 93747 M PHASE%REACTOME%R-HSA-68886.5 M Phase 20873 52717 68121 99152 668450 12534 232440 78887 78798 319149 22628 225745 231123 15077 74360 238799 18536 66296 214552 26413 18541 116733 59046 244329 13001 59021 13000 382030 100039026 67121 56205 52432 71909 76044 78658 237222 71175 74549 66352 30939 67181 52683 70231 17997 18005 73738 68475 53598 208518 100088 236266 12009 99100 103733 22154 98386 74470 104318 101565 16328 259279 103573 14211 83922 171567 51885 19348 68298 215387 26370 76789 71819 72083 70099 101706 233276 103768 74237 22147 16906 22151 22627 99412 27373 22143 53857 22152 227613 22153 22142 22146 67951 73710 13726 22145 66371 71782 545486 238463 68953 75608 170762 108989 231042 227699 208092 223921 227720 66700 380664 269113 66679 18141 23825 107939 69482 71805 54563 19088 19069 70699 67141 72787 64899 18226 218210 105513 14245 64898 71978 19645 108911 73470 16563 75786 15519 70454 18747 216965 71876 16211 234663 19047 66977 320394 19386 102920 73699 11799 52276 59125 218914 59126 12235 217718 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 19384 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 219103 26951 100710 108000 229841 12237 12617 107995 72415 83815 12615 319152 66570 244495 208628 76707 67139 68014 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 21762 12442 22123 60411 66336 59015 19179 69736 19181 67052 19182 67956 232987 23996 12236 19184 236930 110379 26440 69928 19166 13427 76499 19167 71521 13426 26441 52504 13424 26442 228421 69077 20843 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 18751 59029 67089 70247 22196 15267 671392 319168 319167 100986 319186 319178 319183 319182 319190 230376 319176 69654 319181 75296 219072 19324 225659 381306 76478 22367 71955 78177 64383 319169 224640 74498 319965 105988 28135 50850 214444 100042651 76816 54130 217232 56317 625328 59008 78303 18817 319188 66156 15270 381644 56041 216080 69957 17222 75430 68612 18750 52563 624153 76308 22194 68999 52206 100039535 382522 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME%R-HSA-975957.3 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 622534 238217 14852 16785 666669 100040021 67025 100043391 326622 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 67031 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 100043876 100043893 100043423 100042986 20115 67281 76846 625646 100040298 68172 19052 100042740 19951 51792 667618 100040970 267019 56040 67248 100040331 67941 57294 68092 433702 192160 208643 60365 68134 192170 19826 66441 17149 667035 75901 19704 27207 67097 670832 633683 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 27370 233789 71978 65019 103677 629957 226517 20102 74133 229512 20103 71997 668668 667739 14853 672214 66481 225058 100038875 100038991 68028 225363 100043000 67891 100043295 18458 GAP JUNCTION ASSEMBLY%REACTOME%R-HSA-190861.3 Gap junction assembly 14623 118454 14618 14609 14619 14621 14615 225152 14610 353155 14613 14617 14612 14611 14622 14620 14616 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 96%426496 Post-transcriptional silencing by small RNAs 233833 213988 236511 217351 214150 76850 239528 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.6 NOTCH2 Activation and Transmission of Signal to the Nucleus 18011 13388 16449 240055 225164 12805 11487 54485 16450 18129 19164 19165 100042305 208117 59287 100039623 17242 667035 76580 22190 BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME DATABASE ID RELEASE 96%196299 Beta-catenin phosphorylation cascade 225849 93687 26931 21770 26932 12387 14296 73699 72345 212398 19052 19053 51792 56637 12005 11789 226849 TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 96%166020 Transfer of LPS from LBP carrier to CD14 12475 16803 MITOTIC SPINDLE CHECKPOINT%REACTOME%R-HSA-69618.4 Mitotic Spindle Checkpoint 52717 99152 668450 108911 73470 16563 75786 70454 216965 71876 234663 19047 66977 320394 19386 102920 73699 11799 52276 12235 67037 68097 16319 19052 73804 19053 51792 20877 381318 52696 26886 66934 18221 445007 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 108000 229841 12237 103573 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 69912 625534 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 60411 66336 59015 69736 67052 232987 12236 236930 110379 69928 13427 76499 13426 52504 13424 228421 217232 56317 59008 18817 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.4 Acyl chain remodelling of PE 18778 14792 329502 66857 271844 67452 237625 53357 67216 232889 225845 105501 27281 18783 218121 18779 26971 99010 66727 26970 26565 18784 18782 78390 66350 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME%R-HSA-9656249.3 Defective Base Excision Repair Associated with OGG1 18294 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 96%196843 Vitamin B2 (riboflavin) metabolism 319945 52710 54391 18605 11433 69698 ATORVASTATIN ADME%REACTOME DATABASE ID RELEASE 96%9754706 Atorvastatin ADME 12780 18671 22236 18979 28253 269823 13114 DEVELOPMENTAL LINEAGE OF MAMMARY STEM CELLS%REACTOME DATABASE ID RELEASE 96%9938206 Developmental Lineage of Mammary Stem Cells 14165 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 96%8951936 RUNX3 regulates p14-ARF 21803 328572 12400 16653 12399 208727 12443 14312 PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.3 Plasma lipoprotein clearance 100017 93835 100102 11806 67963 238055 22259 11816 65969 11771 11772 71770 667035 13909 22190 218203 320024 22359 223920 18145 20652 22260 15450 232910 11773 11812 16835 11425 110611 54135 171504 16889 67300 12757 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 96%9637628 Modulation by Mtb of host immune system 667035 22190 12010 24088 17533 WAX BIOSYNTHESIS%REACTOME%R-HSA-9640463.3 Wax biosynthesis 245533 67420 245532 330450 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.7 Diseases of Immune System 17087 12475 22031 19697 106759 16150 18034 14061 16151 17874 12229 434174 21898 20201 20202 266632 117149 53791 12491 21899 20193 12675 14161 18033 58992 16621 170743 18035 12258 24088 21897 54445 110135 142980 99571 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.2 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins 268980 66899 67561 REGULATION OF TNFR1 SIGNALING%REACTOME%R-HSA-5357905.8 Regulation of TNFR1 signaling 22241 56480 22030 56424 56489 11796 11798 16150 71648 16151 14694 66105 53376 667035 100041766 71609 22190 14082 66552 76686 432940 12675 21937 52440 30941 22029 229603 73218 22258 17164 268749 106025 21926 74256 263876 216080 76580 21929 22195 24105 12370 19766 11797 GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%6783984 Glycine degradation 100042811 104174 18293 68133 78920 13382 434437 AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.4 Autodegradation of the E3 ubiquitin ligase COP1 56436 17463 26374 57296 20422 26445 26446 19172 19173 19175 19177 26443 11920 26444 19170 66413 667035 22190 59029 67089 70247 22059 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.5 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) 24059 METABOLISM OF RNA%REACTOME DATABASE ID RELEASE 96%8953854 Metabolism of RNA 107508 70047 26416 19094 234594 77305 54401 15381 17164 19655 269061 70616 68598 67959 20462 107701 67480 72047 74326 67500 103573 75956 56031 80744 66101 75705 70225 13684 68879 320632 208643 67418 212880 66585 22380 74351 54723 83486 19134 545085 66877 244672 238831 23983 24010 18521 20227 83701 74255 57905 67229 68479 70312 330361 66177 67797 67050 209416 76167 76522 22184 72654 20222 50996 28035 66899 78372 72886 67225 18949 60321 67178 66492 71715 215051 66618 230596 70052 70767 67922 66070 66381 77644 66810 108160 319322 100034361 66801 237859 19205 68592 27967 68035 217207 76936 67471 69757 68988 110532 208768 71702 76793 22668 68981 67684 20639 209003 229279 227707 101943 81898 67439 94315 20646 192159 53317 15382 53379 56258 59013 98758 11991 11834 15388 15387 66055 68816 67197 54633 67465 69192 67285 236732 67958 68183 76479 20624 66642 75062 19704 27366 228005 28000 13204 76265 100041953 76938 68215 66637 233908 74097 66125 68045 73192 104721 68626 117109 68219 66161 98985 381802 228410 66078 54451 28088 108062 67724 67337 67106 83410 98404 18789 51786 94230 74320 68188 55989 15507 19386 218343 56422 68106 69305 319765 140488 19052 51792 445007 57294 69912 103468 66317 234865 59015 69736 110379 107686 384091 666609 216766 66069 621705 20595 66603 53975 12729 276919 68705 20641 98053 27374 13871 20638 22695 66420 56698 69833 70465 67710 69731 245841 432803 69920 67332 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 24018 17420 67897 12572 13872 20924 23894 14884 56417 210106 72181 52575 75619 227682 83485 94254 224481 66132 66410 67390 217038 15108 69821 71989 101122 51810 68017 21379 380601 233789 103677 226517 74133 229512 71997 18750 11651 238799 243963 66053 66983 230594 214290 218693 103135 72587 104625 66362 109075 66583 27998 72544 50911 69639 72662 18983 66446 227715 74108 104318 68092 433702 12192 11810 80287 11811 69865 71281 110109 72026 71701 72085 230734 56335 53621 338359 104444 68291 72068 210529 100043168 70359 232791 27373 24128 108943 328162 233189 240174 76357 74455 229780 66965 108077 209584 68736 30947 13434 100929 54632 68260 73681 68916 66966 28114 66369 67049 57773 17299 100043886 66757 106248 68205 66628 66246 212528 67134 69786 329504 60507 67667 78890 170762 319582 108989 78697 231042 227699 223921 227720 269113 50783 66679 67678 18141 234699 24127 107939 66094 69482 13209 71805 319618 67207 70640 75901 54563 78651 27756 19069 353190 225929 70699 66373 19045 72787 18226 218210 19046 27207 67097 670832 231413 633683 13207 20044 27050 667279 20085 668144 20084 67186 382492 20055 75617 71978 27370 65019 629957 20102 20103 668668 14853 667739 54188 672214 66481 225058 100038875 100038991 225363 68028 100043000 67891 18458 100043295 622534 14852 238217 16785 666669 100040021 67025 100043391 326622 668182 241053 432502 19989 76808 19899 100043184 19921 19934 100043755 193740 67031 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 20492 72290 116748 100043876 100043893 100043423 100042986 20115 67281 54196 76846 625646 100040298 68172 100042740 19951 19384 380773 667618 228140 67440 100040970 72416 267019 56040 67248 100040331 67941 69125 56200 72515 67676 27993 102614 50912 67619 66878 58184 217109 110816 68327 64340 66138 622469 229504 225027 15481 208144 67996 98956 225160 22608 67276 51796 67973 56488 18114 192160 18572 331401 78394 71713 53414 53817 216156 233073 269470 625193 59028 69823 12181 20382 21771 21762 110809 75273 22123 73666 215193 60365 64934 20383 67674 217995 19179 68278 73674 19181 170722 67755 19182 70579 68272 23996 21681 213895 19184 73826 76130 68134 216987 26440 66231 66254 19166 66511 66249 107829 353258 19167 108014 56095 53319 71340 26441 192170 224823 69207 102462 26442 19826 69072 69077 193116 76367 213773 66997 74412 105372 23997 66441 67205 386612 72554 56436 17149 104662 17463 100040029 67053 78893 57296 52705 20422 230082 26445 245474 26446 223499 19172 269536 19173 80886 19175 70683 13682 100041622 19177 13681 97961 52846 233802 66164 216578 26443 66181 664817 26444 27966 112403 57750 76014 19170 74035 225432 100608 231464 231386 100040177 67010 66413 234374 240255 68147 70650 667035 30877 216345 22190 75416 74213 57315 214627 52530 59029 14113 68979 67089 208366 227522 70247 14791 57316 67045 54364 72198 65961 622491 68533 18753 170791 20630 14105 20637 53607 70044 56070 67039 15568 72459 11737 56194 69583 100336 671392 52040 140486 72935 13211 56215 22631 DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.5 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) 11998 54140 26361 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 96%5668541 TNFR2 non-canonical NF-kB pathway 12234 14103 21943 56436 53859 17463 57296 20422 26445 26446 19172 19173 19175 19698 19177 21402 26443 26444 19170 21936 66413 26965 667035 22190 230979 59029 67089 103583 70247 21947 21937 21938 18383 21935 240873 21926 69583 24099 57916 22163 22164 245527 11797 326623 171211 22030 72049 22031 85030 50930 21944 11796 21934 27279 18034 21940 21941 21949 21948 17000 16994 16992 13608 13607 21942 22200 21762 22123 12675 19179 22192 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 96%5690338 Defective ABCC6 causes PXE 27421 DEPOLYMERIZATION OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 96%4419969 Depolymerization of the Nuclear Lamina 382030 12534 14245 16906 224640 18751 64898 13726 18750 67181 380664 64899 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 96%6787450 tRNA modification in the mitochondrion 52575 68291 70359 66966 66132 15108 72026 72085 230734 DEFECTIVE MMAB CAUSES MMA, CBLB TYPE%REACTOME DATABASE ID RELEASE 96%3359471 Defective MMAB causes MMA, cblB type 77697 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.2 Signaling by PDGFRA extracellular domain mutants 20848 74769 15461 18595 18708 18709 18176 20846 18706 20662 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.2 Biosynthesis of E-series 18(R)-resolvins 16993 11687 11689 ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.9 Oncogenic MAPK signaling 74244 20779 12322 12323 109880 108058 12325 26413 26417 12988 109905 19047 54401 70686 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 75590 110157 235584 23980 67603 18218 14161 63953 21894 215449 11836 26372 109689 56463 216869 26936 26403 21848 72399 11774 18673 330286 16452 67726 110135 100986 99571 78781 22330 19317 16706 11610 76156 210106 17532 66549 16905 67095 14359 56392 69923 338523 19046 640703 18015 17169 101809 114715 114716 16653 23971 12125 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME%R-HSA-5632928.2 Defective Mismatch Repair Associated With MSH2 17685 17686 17688 HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 96%2024096 HS-GAG degradation 15529 11603 23888 15931 20971 20969 15530 14734 27419 15442 103978 27029 71951 20970 14735 14733 545291 15932 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME DATABASE ID RELEASE 96%5619072 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) 22232 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME%R-HSA-9672396.3 Defective cofactor function of FVIIIa variant 14069 14058 14071 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.5 PKA activation in glucagon signalling 18747 224129 19088 11512 11513 11514 19087 19084 11515 18749 104110 432530 210044 104111 19085 INTERLEUKIN-35 SIGNALLING%REACTOME DATABASE ID RELEASE 96%8984722 Interleukin-35 Signalling 20848 16159 54721 16451 50498 12330 20849 16452 16162 20846 50931 16195 PROTEIN LIPOYLATION%REACTOME%R-HSA-9857492.1 Protein lipoylation 67164 14148 68133 78920 623661 13171 79464 235339 70316 56748 TGFBR1 KD MUTANTS IN CANCER%REACTOME%R-HSA-3656532.4 TGFBR1 KD Mutants in Cancer 21803 21812 21813 17126 17127 ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.6 Abacavir metabolism 75894 76952 18534 ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME%R-HSA-879415.2 Advanced glycosylation endproduct receptor signaling 12343 19089 13200 434174 11596 12340 20203 20210 11820 26413 26417 16854 CASP5-MEDIATED SUBSTRATE CLEAVAGE%REACTOME DATABASE ID RELEASE 96%9960525 CASP5-mediated substrate cleavage 12367 16176 16173 69146 SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME%R-HSA-75876.10 Synthesis of very long-chain fatty acyl-CoAs 56348 26568 54326 257633 433256 83603 50790 15487 328845 74205 57874 68801 30963 170439 106529 54325 66775 12686 94180 14081 216739 74559 243078 70757 NFE2L2 REGULATING TCA CYCLE GENES%REACTOME DATABASE ID RELEASE 96%9818025 NFE2L2 regulating TCA cycle genes 15926 18024 17436 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.4 Nucleotide Excision Repair 22632 70620 11545 16881 66983 71101 71991 12848 100043806 26891 319955 56456 26370 77593 56031 56505 68058 225280 26893 21399 56249 69714 227195 109275 26894 68142 11546 13870 108679 233875 70020 19358 19359 235134 22590 22591 107986 26572 22592 50505 26895 57905 13716 56438 667035 13871 22190 66420 67439 69833 11461 67710 245841 69920 20022 14885 209357 66467 20020 231329 20021 69241 56469 66671 17749 100043714 17420 12572 13872 20610 23894 14884 22196 100043429 11834 229615 27015 69745 59001 26754 22594 16882 19687 19718 69263 66979 93765 93836 18538 28000 68275 106344 72151 18971 68240 18972 252870 19891 18973 18974 67967 99375 72584 13194 REGULATION OF PD-L1(CD274) TRANSCRIPTION%REACTOME%R-HSA-9909649.2 Regulation of PD-L1(CD274) transcription 21415 232440 12387 13626 319149 19697 16478 16842 15077 66310 140858 97064 52615 19646 213464 11910 214162 17869 245688 22601 15251 23808 18109 21679 15267 21676 319168 21678 319167 14281 16362 319186 21677 328572 319178 319183 319182 21414 319190 21416 231051 14282 319176 18034 319181 57261 18024 13819 12914 14056 319169 20846 20848 625328 16476 78303 18033 319188 15270 624153 382522 SIGNALING BY FGFR2 IN DISEASE%REACTOME DATABASE ID RELEASE 96%5655253 Signaling by FGFR2 in disease 14172 80857 14180 14178 14177 67112 68092 64654 14175 14174 14173 433702 14164 68705 98053 66420 69833 67710 245841 69920 20022 20020 327826 231329 20021 69241 17749 100043714 14183 18176 14388 20662 15461 18803 80903 18708 14165 18706 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME DATABASE ID RELEASE 96%5619109 Defective SLC6A2 causes orthostatic intolerance (OI) 20538 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.4 Defective F9 activation 14071 14723 14724 54368 14729 109821 GPER1 SIGNALING%REACTOME%R-HSA-9634597.3 GPER1 signaling 14702 14696 76854 19088 20779 19087 19084 104110 14697 14678 14677 14687 14679 14710 432530 14699 210044 66066 104111 14700 14688 18747 14708 14706 14704 16412 14695 224129 11512 14693 11513 11514 64337 11515 14709 18749 16402 14701 242851 19085 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME%R-HSA-162710.6 Synthesis of glycosylphosphatidylinositol (GPI) 70325 239827 327942 55981 66459 18700 67292 72084 13481 110417 433931 230801 18701 668145 67556 27392 56703 SHC-MEDIATED CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 96%5654704 SHC-mediated cascade:FGFR3 15461 14172 80857 14180 80903 64654 14175 18176 20662 14173 14164 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.6 Non-integrin membrane-ECM interactions 13138 60409 14173 244431 192897 13405 20650 16398 13528 13527 20649 16403 24051 20648 20391 22139 24053 24052 16651 268534 20392 15529 11603 20971 16412 20969 16775 16776 16777 21923 16779 16780 226519 16416 16782 16772 23928 20970 16773 16774 21825 22370 18189 18591 109711 15530 16419 12305 18214 22288 16410 21803 57764 12361 13497 18590 18750 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.3 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 12914 66494 209456 225655 22059 12177 69076 60599 22061 11920 22062 71361 12028 12122 21981 68428 KW2449-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 96%9702569 KW2449-resistant FLT3 mutants 14255 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 96%69231 Cyclin D associated events in G1 54124 20459 12575 211586 13555 19645 21781 21402 12571 12567 12443 12566 12444 12445 13557 12447 242705 26965 667035 27401 22190 12448 12577 12576 100043858 12580 12579 12578 11350 13559 104394 66671 17420 73699 12572 71978 17096 19052 19053 51792 19650 19651 16452 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.3 Interaction between PHLDA1 and AURKA 21664 20878 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME%R-HSA-9694686.7 Replication of the SARS-CoV-2 genome 13207 22346 19645 67197 SPHINGOLIPID CATABOLISM%REACTOME%R-HSA-9845614.3 Sphingolipid catabolism 230379 67916 66190 19012 50784 81535 171168 20397 67689 433323 DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME%R-HSA-5619054.4 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) 54403 FORMATION OF AXIAL MESODERM%REACTOME%R-HSA-9796292.3 Formation of axial mesoderm 14106 15375 12387 21414 22601 20997 15376 20423 16842 17126 17127 384452 21679 21677 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.5 Activation of BAD and translocation to mitochondria 100039786 54401 22628 22631 12015 55948 22629 19058 11651 11652 12122 12043 22627 19057 23797 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 96%8963898 Plasma lipoprotein assembly 17777 18747 66397 11812 11806 11813 11814 238055 11425 27801 18453 11816 18749 11303 232345 11807 11808 SIGNALING BY NOTCH2%REACTOME%R-HSA-1980145.4 Signaling by NOTCH2 328572 18011 13388 16449 240055 225164 12805 11487 54485 16450 18129 333639 270118 667035 22190 14128 15205 14939 19164 19165 15208 100042305 208117 19664 59287 100039623 17242 76580 103806 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME%R-HSA-174495.3 Synthesis And Processing Of GAG, GAGPOL Polyproteins 73711 22088 67123 330192 667035 22190 66914 18108 107305 72543 194309 52348 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME DATABASE ID RELEASE 96%9682706 Replication of the SARS-CoV-1 genome 13207 22346 19645 67197 DEFECTIVE PGM1 CAUSES CDG1T%REACTOME DATABASE ID RELEASE 96%5609974 Defective PGM1 causes CDG1t 72157 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 96%8934593 Regulation of RUNX1 Expression and Activity 233833 12400 236511 17454 18854 20779 12571 12443 12444 12445 213988 217351 214150 19247 76850 239528 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME%R-HSA-5654227.4 Phospholipase C-mediated cascade; FGFR3 14172 80857 18803 14180 80903 64654 14175 14173 14164 LANOSTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9969896 Lanosterol biosynthesis 20775 319554 17855 110196 14137 192156 100040592 74411 68603 14593 16987 110460 DEFECTIVE CLEAVAGE OF FV VARIANT AT A.A.534%REACTOME DATABASE ID RELEASE 96%9930449 Defective cleavage of FV variant at a.a.534 14067 19128 19123 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.3 Transport of fatty acids 77701 26569 225579 11815 26457 DEFECTIVE MPDU1 CAUSES CDG-1F%REACTOME DATABASE ID RELEASE 96%4687000 Defective MPDU1 causes CDG-1f 24070 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 96%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB 17161 109731 DEFECTIVE ALG12 CAUSES CDG-1G%REACTOME%R-HSA-4720489.4 Defective ALG12 causes CDG-1g TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME DATABASE ID RELEASE 96%75944 Transcription from mitochondrial promoters 216151 15278 21780 208595 CELLULAR RESPONSE TO MITOCHONDRIAL STRESS%REACTOME%R-HSA-9840373.2 Cellular response to mitochondrial stress 67013 66839 13665 12034 67204 15467 66592 26905 27377 RESPIRATORY SYNCYTIAL VIRUS INFECTION PATHWAY%REACTOME%R-HSA-9820952.2 Respiratory Syncytial Virus Infection Pathway 16451 56208 23989 100038882 59024 327987 70625 68975 234959 15519 15529 94112 23888 13001 20971 16211 13000 28077 70208 100039026 19047 19106 20969 13649 171285 71951 20970 56771 80509 14735 67224 19014 15516 66999 328572 17087 15530 66286 103573 17755 103978 18550 69790 21898 14733 26896 69019 15481 12914 108098 15977 14734 67923 71586 56529 230073 228607 217069 16001 13051 19345 66172 271457 19344 192191 24088 78334 54131 20933 56438 170786 27061 667035 22190 75613 381379 23806 11603 67219 170779 21899 170743 264064 142980 76199 319186 56791 66624 67279 12475 19045 54721 20847 19046 76687 15975 246728 216154 51813 75717 69792 67381 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME DATABASE ID RELEASE 96%1247673 Erythrocytes take up oxygen and release carbon dioxide 19743 15129 15122 20533 12346 12349 12351 11826 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 96%112126 ALKBH3 mediated reversal of alkylation damage 69113 69090 75452 77987 DISEASES OF MITOCHONDRIAL BETA OXIDATION%REACTOME DATABASE ID RELEASE 96%9759774 Diseases of mitochondrial beta oxidation 17850 109136 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.4 Negative epigenetic regulation of rRNA expression 232440 319149 667501 57230 21429 20019 269003 15077 21340 17191 21339 21341 64424 22130 13871 75316 66420 70333 69833 116848 66136 245841 20017 101867 14885 209357 66467 13436 66671 13433 17749 100043714 17420 12572 13872 23894 14884 93762 15267 319168 20937 319167 319186 319178 319183 319182 319190 319176 21374 319181 50724 60406 93759 94246 20467 100041953 20018 71954 20016 319169 20466 625328 78303 319188 15270 433759 15182 624153 382522 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME DATABASE ID RELEASE 96%425397 Transport of vitamins, nucleosides, and related molecules 77701 11739 229782 433923 11740 242585 73836 243328 72621 225579 56327 330064 11416 70484 114304 26569 108652 13340 22232 269346 434203 63959 71279 11815 228368 58246 24060 26457 107566 MATRIGLYCAN BIOSYNTHESIS ON DAG1%REACTOME DATABASE ID RELEASE 96%9939291 Matriglycan biosynthesis on DAG1 216395 67843 13138 75847 108902 243853 98388 228366 24060 68273 246179 16795 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME DATABASE ID RELEASE 96%202430 Translocation of ZAP-70 to Immunological synapse 12500 16818 12501 12502 22637 14969 12504 14968 19260 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 96%5660668 CLEC7A inflammasome pathway 16176 18033 66824 240354 19697 12370 G2 PHASE%REACTOME DATABASE ID RELEASE 96%68911 G2 Phase 13557 12428 12427 13555 12566 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME%R-HSA-6814122.3 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding 12469 12461 14702 12464 14696 14675 24012 19739 50782 14697 50779 14710 14699 66066 14700 67466 14688 13001 14708 13000 14672 14706 100039026 14704 14695 14676 14693 12465 64337 14709 14682 12466 14701 21454 12462 12467 12468 INHIBITION OF MEMBRANE REPAIR%REACTOME DATABASE ID RELEASE 96%9635644 Inhibition of membrane repair 15239 NUCLEAR SIGNALING BY ERBB4%REACTOME%R-HSA-1251985.7 Nuclear signaling by ERBB4 12991 11491 18183 83961 100042150 20779 12223 11816 13874 20850 15200 211323 20203 20185 68652 80707 13982 22601 14580 19164 19165 100042305 208117 59287 20692 17122 100039623 231821 20315 18667 16765 DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.4 Defective ABCB11 causes PFIC2 and BRIC2 27413 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9630791.4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 12567 12578 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME%R-HSA-3301854.4 Nuclear Pore Complex (NPC) Disassembly 18141 107939 69482 12534 71805 54563 19069 70699 72787 18226 218210 69912 103468 19386 234865 12442 59125 59126 217718 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 TERMINAL PATHWAY OF COMPLEMENT%REACTOME DATABASE ID RELEASE 96%166665 Terminal pathway of complement 15139 12759 12274 230558 110382 109828 69379 12279 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.5 EPH-ephrin mediated repulsion of cells 13836 17395 11487 22612 19353 11771 11772 71770 74325 14360 13848 22325 13846 13845 270190 13842 13840 232910 17390 11773 13841 13839 13838 13837 13637 57257 17096 13636 13643 19164 13642 21844 19165 13641 13640 100042305 13639 13844 208117 13638 59287 100039623 67300 13429 13835 12757 HCMV EARLY EVENTS%REACTOME%R-HSA-9609690.2 HCMV Early Events 20602 13626 319149 18854 12412 15077 13163 52615 19646 234663 21849 245688 16412 19386 13649 68097 621893 319162 15267 319173 319163 319168 319167 170762 108989 231042 227699 223921 227720 445007 269113 319186 66679 18141 319178 319183 107939 319182 69482 71805 21372 319190 56455 54563 19069 70699 319176 72787 319181 18226 13712 218210 81004 56310 15183 20185 69912 103468 14056 235661 319169 234865 59015 69736 78303 18033 319188 110379 13427 319189 13426 13424 382522 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 96%156588 Glucuronidation 394433 22235 71773 100727 100559 231396 394434 94284 552899 223337 242585 216558 67883 22236 70484 94215 72094 213012 394436 MASITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669924 Masitinib-resistant KIT mutants 16590 GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.6 Glutamate Neurotransmitter Release Cycle 242607 233977 67760 65106 14660 20513 19339 22318 20614 20979 68507 20907 327814 12889 20511 22249 20510 216456 20512 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.2 Defective gamma-carboxylation of F9 56316 14071 TRANSLESION SYNTHESIS BY POLH%REACTOME%R-HSA-110320.3 Translesion Synthesis by POLH 68275 106344 22230 72151 68240 19891 80905 19687 19718 69263 217365 244666 269523 667035 22190 68098 18538 GDP-FUCOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%6787639 GDP-fucose biosynthesis 234730 69064 22122 75540 228368 218138 FCGR ACTIVATION%REACTOME%R-HSA-2029481.3 FCGR activation 20963 246256 14131 15162 12502 17096 14129 14360 22612 14191 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.2 Phenylalanine and tyrosine metabolism 14874 15233 234724 18478 15445 70266 14085 14204 110391 13180 66514 MET RECEPTOR RECYCLING%REACTOME%R-HSA-8875656.2 MET receptor recycling 11845 19341 12929 12928 260302 19342 14388 15234 17295 LDL REMODELING%REACTOME%R-HSA-8964041.4 LDL remodeling 17777 103161 238055 18453 MITOCHONDRIAL RNA DEGRADATION%REACTOME%R-HSA-9836573.1 Mitochondrial RNA degradation 231413 338359 75619 104444 380773 21379 72416 380601 71701 BIOSYNTHESIS OF MARESINS%REACTOME%R-HSA-9018682.3 Biosynthesis of maresins 13850 13106 72303 13077 11689 56448 13114 TRNA AMINOACYLATION%REACTOME%R-HSA-379724.3 tRNA Aminoacylation 70560 67895 71984 224805 353172 70791 68915 230577 226539 71807 107508 20226 69955 244141 107045 226414 97541 216443 22375 234734 107271 27267 105148 23874 231872 70223 66143 15115 110960 66590 22321 71941 70120 381314 104458 67417 102436 74776 85305 109093 212679 13722 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME DATABASE ID RELEASE 96%8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 66902 68981 16153 19188 56044 11840 12631 50926 667310 66162 18569 12798 18738 268373 11632 20849 12340 18826 53379 17319 18788 12306 98758 15526 20656 21351 14873 215449 21454 16906 667618 224105 17698 12346 15978 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.3 TFAP2 (AP-2) family regulates transcription of other transcription factors 17684 21420 21418 18741 AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.4 AURKA Activation by TPX2 20873 68121 12534 78887 15366 22628 225745 231123 227613 72119 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 83922 75296 26370 76707 219072 13589 225659 18472 76478 78177 28135 214444 76816 20878 54130 18817 381644 13427 22627 13424 27373 ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.4 Aberrant regulation of mitotic cell cycle due to RB1 defects 52717 99152 668450 12575 211586 13555 19645 21781 12571 12567 12443 12566 12444 12445 13557 12447 242705 56371 27401 12448 12577 12576 217232 56317 59008 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 DEFECTIVE PMM2 CAUSES CDG-1A%REACTOME%R-HSA-4043911.4 Defective PMM2 causes CDG-1a 54128 REGULATION OF PD-L1(CD274) EXPRESSION%REACTOME%R-HSA-9909648.1 Regulation of PD-L1(CD274) expression 233833 16451 21415 232440 12387 13200 13626 319149 72297 22628 16478 16842 12567 12443 15077 269523 66310 140858 97064 18566 52615 19646 213464 11910 214162 13001 13000 100039026 17869 245688 20747 22601 15251 23808 18109 244373 18005 60533 76580 108099 16362 328572 66357 21414 21416 231051 18024 12914 21762 22123 19179 19181 19182 23996 19184 16476 18033 26440 19166 19167 26441 26442 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 21679 15267 21676 319168 21678 319167 14281 226144 76850 239528 319186 21677 319178 319183 319182 193670 54197 236511 319190 26754 241113 14282 70377 319176 18034 216440 319181 20014 213988 57261 103963 217351 56637 214150 69038 13135 13819 66753 67819 26554 14056 116891 17454 20338 319169 67075 105787 108079 20846 19079 20848 108097 625328 78303 319188 15270 58205 19082 80286 624153 68292 16430 382522 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 96%186797 Signaling by PDGF 74769 20750 17973 20779 20851 12927 20850 18550 107746 14786 20852 12929 19248 12928 18791 19247 12830 12829 12828 12827 18595 12826 18176 18815 20846 20662 218397 12841 20848 15461 21826 12840 17974 21825 18803 245026 12839 71785 18708 18709 21827 18591 12835 21828 18706 12834 18596 12833 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-1839128.3 FGFR4 mutant receptor activation 14186 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 96%5654727 Negative regulation of FGFR2 signaling 14172 80857 14180 14178 12402 14177 67112 24064 64654 17346 14175 14174 14173 14164 109880 667035 22190 19247 26413 26417 327826 19052 19053 51792 80903 14165 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 96%419812 Calcitonin-like ligand receptors 11535 12310 54598 223780 54409 12311 56089 51801 15874 INTEGRIN SIGNALING%REACTOME%R-HSA-354192.4 Integrin signaling 20779 11651 12927 20963 12928 19395 12988 20416 109905 19419 54519 20662 22371 16399 14083 14268 16416 14161 21894 215449 19246 56508 223864 110135 99571 18607 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.3 Defective F8 binding to the cell membrane 14069 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME%R-HSA-9629232.3 Defective Base Excision Repair Associated with NEIL3 234258 DEFECTIVE ALG9 CAUSES CDG-1L%REACTOME DATABASE ID RELEASE 96%4720454 Defective ALG9 causes CDG-1l 102580 FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME DATABASE ID RELEASE 96%9664323 FCGR3A-mediated IL10 synthesis 246256 14131 19088 234779 19108 19087 19084 22612 104110 20963 16153 432530 210044 104111 229709 14360 16438 16439 18747 640703 224129 16440 11512 12502 11513 11514 17096 11515 14191 18749 18803 15162 14129 19085 PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-HSA-3215018.5 Processing and activation of SUMO 100043429 75826 223870 320213 56459 50995 20610 22196 SUMOYLATION OF NUCLEAR ENVELOPE PROTEINS%REACTOME DATABASE ID RELEASE 96%9793242 SUMOylation of nuclear envelope proteins 22196 EARLY SARS-COV-2 INFECTION EVENTS%REACTOME%R-HSA-9772572.4 Early SARS-CoV-2 Infection Events 56208 66383 67443 78610 225326 15530 50528 18186 70008 19645 171283 103978 105513 269523 18550 14733 15529 11603 23888 13207 20971 20969 14734 66371 68953 75608 71951 20970 22346 14735 208092 75669 66700 67197 P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME%R-HSA-193704.3 p75 NTR receptor-mediated signalling 11848 102098 11491 19697 16150 20663 12367 22324 18759 192656 277360 17874 192662 16179 667035 22190 18049 22325 622434 545156 16443 12015 57257 19164 20662 17207 19165 12366 100042305 16800 208117 59287 100039623 13605 12070 109904 230972 213498 207212 71704 234094 223435 56349 16801 94275 19418 75547 19353 18053 72754 18412 69632 213649 24001 224014 56321 230098 53972 30938 15183 77669 22034 442801 72843 226970 54126 101497 67733 269608 328967 14163 26382 268739 26419 14674 73341 20598 21844 18033 433759 18035 22627 15182 17136 68585 12125 18377 236915 109934 235402 INTERLEUKIN-15 SIGNALING%REACTOME%R-HSA-8983432.5 Interleukin-15 signaling 14389 16451 16169 16168 20663 20662 16453 20851 20848 20850 16185 14784 16186 20416 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.6 TP53 Regulates Metabolic Genes 14381 233833 12866 12865 100041785 22628 11651 11652 19211 333182 216456 17708 17709 17710 100039786 382985 54401 55948 22059 14751 50493 22166 108099 380975 76850 239528 84682 670717 236511 241113 56717 17992 22061 213988 319801 217351 14776 214150 64930 66508 545987 54170 75747 74747 22084 12858 52187 17454 68576 66096 83409 74370 12857 22631 68441 105787 22629 268706 108079 19079 245670 14660 108097 110323 230784 18477 12861 21672 20463 22627 19082 56716 12862 12868 23797 66142 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 96%380287 Centrosome maturation 20873 68121 12534 78887 22628 225745 231123 227613 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 259279 83922 171567 51885 75296 26370 76789 72083 12537 76707 233276 103768 74237 219072 13589 225659 18472 76478 78177 28135 214444 76816 54130 18817 381644 13427 22627 13424 27373 SWI SNF CHROMATIN REMODELERS%REACTOME%R-HSA-9932451.1 SWI SNF chromatin remodelers 67155 239985 20586 210982 105246 20588 243842 20587 70127 56456 14025 29861 269397 19708 268996 66993 12055 12054 11461 77045 83766 93760 66923 26992 68094 83796 83797 57376 72057 58208 77044 DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 96%212676 Dopamine Neurotransmitter Release Cycle 233977 108030 214084 22343 27204 12361 19339 22318 20965 20614 20964 20979 68507 20907 327814 319924 12889 22249 22342 CA ACTIVATED K+ CHANNELS%REACTOME%R-HSA-1296052.3 Ca activated K+ channels 84036 140493 16531 16534 16533 58802 140492 435726 72413 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME%R-HSA-6794362.6 Protein-protein interactions at synapses 13823 18213 75409 14811 14810 386750 23859 14814 14813 192167 54525 233067 20910 57267 228836 331461 226352 242667 56376 171180 272381 216856 58234 13385 26558 26557 216028 53310 74342 13383 26556 243961 19024 67533 217692 19268 107065 13169 380785 106025 20168 13822 14251 14816 269587 224997 60367 108071 245537 239250 18189 68507 18190 327814 76965 70530 11784 245450 225875 245446 19280 14252 53623 14799 14802 233977 22343 54526 60510 14812 108030 20980 12361 20979 20907 319924 22342 CERITINIB-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717323 ceritinib-resistant ALK mutants 11682 RHOBTB1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 96%9013422 RHOBTB1 GTPase cycle 26891 51796 56320 12461 26554 20462 69288 242202 19877 15381 106504 109331 12848 17920 22352 19878 56381 19655 53382 12468 100043806 269061 FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-HSA-2029480.3 Fcgamma receptor (FCGR) dependent phagocytosis 17913 246256 17973 18806 14131 17909 105855 242687 330319 76884 22612 11308 22324 53357 16885 17886 108100 12928 11461 18754 18805 101314 26413 229709 26417 14360 16438 16439 15519 22325 11350 104759 16440 18753 12502 57257 140579 17096 330662 11465 15162 140580 18708 18709 20430 18479 15516 18706 74769 234779 17918 76709 19353 73178 20963 12229 56443 381925 18807 71910 80987 68089 67771 12631 11867 56378 66713 74117 245880 14191 14083 18016 22376 215280 18803 68524 50884 17925 83767 17882 14129 329165 LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%9615710 Late endosomal microautophagy 15129 21821 68146 105513 15185 667035 22190 66905 107305 72543 194309 18541 52348 15481 73711 22088 67123 330192 66914 12638 19752 66371 11520 26369 68953 57320 75608 208092 66700 NRCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447038 NrCAM interactions 18187 11733 13385 53310 13383 319504 21367 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 96%192105 Synthesis of bile acids and bile salts 13116 56050 17977 76303 71720 228983 13124 12642 17978 26459 17117 99031 105349 71240 100273 27413 64291 20181 12012 20186 13123 93732 104086 13122 77337 208665 101502 83702 26458 15488 170789 DEFECTIVE SLC35A1 IN SIALIC ACID METABOLISM CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.4 Defective SLC35A1 in sialic acid metabolism causes congenital disorder of glycosylation 2F (CDG2F) 24060 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 96%5576894 Phase 1 - inactivation of fast Na+ channels 16506 70357 80334 16508 56461 56543 MRNA EDITING: A TO I CONVERSION%REACTOME%R-HSA-75064.4 mRNA Editing: A to I Conversion 56417 110532 GLYCOSPHINGOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9840309 Glycosphingolipid biosynthesis 239559 53897 108105 223753 14344 14343 56336 26879 56386 22234 50935 14421 54218 20444 22239 20454 225742 26938 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%629594 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 11438 110834 110902 11435 11440 108015 108043 11444 110835 231252 APOPTOSIS%REACTOME%R-HSA-109581.6 Apoptosis 12387 12550 211586 13176 13555 22628 20230 21781 11651 11652 227753 74268 72565 66593 26413 26417 16211 54401 55948 12015 12371 19877 12369 68097 14453 11518 13169 18810 21981 22352 56702 50709 14957 18107 50708 14958 17087 80838 209456 72993 56455 13368 13144 13347 69635 97165 13143 107449 94275 107448 56369 22062 21898 12578 26419 21762 22123 19058 19179 19181 19182 23996 19184 26440 19166 16906 12043 19167 22627 26441 12048 26442 11789 69077 12125 66997 23997 14103 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 21873 13511 26443 13510 26444 27061 21872 12367 19170 18772 109620 13512 66413 667035 22190 59029 67089 70247 269582 100039786 12261 18753 22059 14939 14102 12368 22035 224105 12370 19766 11797 670717 22030 12475 21933 16646 69146 225471 106759 11798 12018 22061 12028 54722 434174 12122 71609 14082 70415 18761 74143 78514 223255 19057 56215 171543 74006 67013 14272 22631 22629 12169 14083 20848 11783 23797 20740 SIGNALING BY EGFR IN CANCER%REACTOME%R-HSA-1643713.4 Signaling by EGFR in Cancer 12539 13649 21802 12402 12223 18176 14388 71920 20662 13874 15461 15200 18803 11839 667035 22190 13645 18708 18706 20416 15519 SIGNALING BY FGFR2 FUSIONS%REACTOME%R-HSA-8853333.2 Signaling by FGFR2 fusions 14183 DARPP-32 EVENTS%REACTOME%R-HSA-180024.6 DARPP-32 events 18747 21770 640703 19055 19056 19088 19049 73699 19087 19058 19084 19045 18577 110385 18749 238871 19052 19053 51792 12568 19057 19085 FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME DATABASE ID RELEASE 96%2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface 14134 DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%R-HSA-3323169.4 Defects in biotin (Btn) metabolism 18563 78038 110821 66904 72039 107476 26363 110948 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.4 Interaction With Cumulus Cells And The Zona Pellucida 71078 22788 22786 14595 12659 56622 74468 22787 11495 SRC ACTIVATES STAT3 IN A QUANTITATIVE MANNER, THROUGH CADHERIN-11 (CDH11), RAC1 AND GP130 (IL6ST)%REACTOME%R-HSA-9958810.1 SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) 12385 22325 12388 12387 227377 12550 12552 20779 21844 19353 330662 104836 667035 22190 13040 140580 16480 13030 226970 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME%R-HSA-9018678.5 Biosynthesis of specialized proresolving mediators (SPMs) 67103 16993 17001 15446 11684 11690 13850 13106 11687 72303 13077 56448 13076 13114 19225 11689 14865 LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037629 Lewis blood group biosynthesis 14347 26878 14348 14345 26877 54218 14422 20443 54613 14344 93961 50935 DEFECTIVE REGULATION OF TLR7 BY ENDOGENOUS LIGAND%REACTOME%R-HSA-9824856.1 Defective regulation of TLR7 by endogenous ligand 170743 FORMATION OF NEURONAL PROGENITOR AND NEURONAL BAF (NPBAF AND NBAF)%REACTOME%R-HSA-9934037.1 Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) 67155 239985 20586 20588 20587 70127 56456 14025 29861 269397 19708 268996 66993 12055 12054 11461 77045 83766 93760 68094 83796 83797 57376 72057 58208 NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 96%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways 66824 216799 19697 16150 16151 192656 16179 26416 26409 257632 29857 107607 19094 26415 12371 108960 12366 12362 74256 12363 22166 21929 195046 56338 16396 12370 227290 15516 11797 15368 26399 11796 18034 383619 19200 66513 93765 55991 66589 22034 66724 68652 54483 332579 12675 268973 18033 18439 12043 67955 12048 11820 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 96%68882 Mitotic Anaphase 52717 99152 668450 12534 238799 116733 30939 100088 98386 103573 22147 16906 22151 22143 53857 22152 227613 22153 22142 22146 67951 73710 13726 22145 66371 71782 545486 238463 68953 75608 170762 227699 208092 66700 380664 269113 23825 107939 69482 71805 70699 72787 18226 105513 71978 108911 73470 16563 75786 70454 216965 71876 16211 234663 19047 66977 320394 19386 102920 73699 11799 52276 218914 12235 67037 20842 68097 16319 19052 73804 19053 51792 20877 381318 19384 24061 52696 26886 66934 18221 445007 19357 226849 225849 72155 26931 21770 26932 70385 57294 56455 226747 17120 26951 100710 108000 229841 12237 12617 107995 72415 83815 12615 66570 244495 208628 76707 67139 68014 83431 13589 67849 69912 625534 13006 18472 67733 103468 66468 76464 66442 67629 235661 56430 234865 56150 21762 12442 22123 60411 66336 59015 19179 69736 19181 67052 19182 232987 23996 12236 19184 236930 110379 26440 69928 19166 13427 76499 19167 71521 13426 26441 52504 13424 26442 228421 69077 20843 66997 23997 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 26443 26444 19170 66413 667035 22190 59029 67089 70247 22196 22367 71955 64383 224640 319965 105988 50850 100042651 217232 56317 59008 18817 66156 216080 69957 17222 75430 68612 52563 22194 68999 52206 100039535 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 96%5627123 RHO GTPases activate PAKs 67268 67938 640703 17904 107589 18481 17880 13043 77579 19353 71960 18016 16885 17886 19046 224105 329251 17931 192176 18479 RHOBTB3 ATPASE CYCLE%REACTOME%R-HSA-9706019.5 RHOBTB3 ATPase cycle 26554 12447 56382 319642 66905 22346 230654 73296 15239 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.4 Phospholipase C-mediated cascade: FGFR1 80857 18803 14180 14177 67112 64654 14175 14174 14165 14173 14164 ACYL CHAIN REMODELING OF CL%REACTOME DATABASE ID RELEASE 96%1482798 Acyl chain remodeling of CL 53357 66826 225010 18783 97212 231086 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 96%1169410 Antiviral mechanism by IFN-stimulated genes 16451 56208 12534 17973 74153 20892 19043 100038882 193740 17999 26417 19255 16211 100039592 16648 19106 100037258 19386 73699 55948 19052 11465 19053 381686 51792 16649 445007 226849 66892 26399 18550 24015 69912 15481 13684 103468 208643 234865 230073 12675 228607 59015 217069 69736 13690 110379 18803 69928 192170 14469 54131 13682 13681 16150 23992 21357 16151 18148 667035 22190 11461 24110 23806 55932 66369 22059 23960 225467 67781 22196 246727 12362 56417 231655 20698 170762 13665 286940 108989 67204 231042 227699 223921 26905 192176 230861 211948 227720 15512 269113 15482 66679 18141 107939 56791 67513 69482 23988 67030 71805 16201 112419 54563 16646 19069 101831 24014 70699 72787 18226 104806 218210 18712 20617 13211 71885 93765 14087 100040608 246728 237211 110606 72775 229898 14088 14272 60534 20846 20848 22194 CREATINE METABOLISM%REACTOME DATABASE ID RELEASE 96%71288 Creatine metabolism 240332 76722 102857 12715 14431 12709 67092 14411 243616 12716 ESR-MEDIATED SIGNALING%REACTOME DATABASE ID RELEASE 96%8939211 ESR-mediated signaling 22632 233833 232440 319149 268980 20779 16478 12443 11651 12389 11652 15077 18710 12005 12576 26413 26417 15519 100039592 17869 13649 21802 18176 20842 15461 24061 19014 18708 18709 15516 19357 18706 18607 328572 12400 17395 17392 18127 17977 12223 16589 14462 21374 71920 103573 13874 13712 17978 15200 59035 268903 107951 13006 12914 235459 11909 640703 83602 12455 56484 16001 16476 11839 12043 13645 17863 20843 18762 20683 14732 14697 68705 13610 98053 66420 69833 14710 67710 14699 245841 13983 66066 69920 14700 20022 20020 14708 231329 14706 20021 69241 14704 13982 17749 100043714 14695 19060 14693 64337 14709 15267 14701 319168 18667 20698 319167 14281 76850 239528 319186 319178 12705 319183 14702 20807 319182 81601 14696 236511 319190 14282 319176 319181 213988 14678 14677 14229 217351 214150 67393 12648 14679 13033 99982 14228 18986 17979 193796 14688 228913 13207 21887 15375 55960 268527 17390 107351 17454 26424 21786 15469 319169 22282 22278 18519 100041004 100043508 14083 625328 78303 319188 68268 15270 433759 12390 20315 17393 102193 67738 624153 71393 23797 242851 382522 P75NTR SIGNALS VIA NF-KB%REACTOME%R-HSA-193639.3 p75NTR signals via NF-kB 19697 16150 18759 192656 18053 17874 18412 18033 16179 667035 18035 22190 18049 22034 ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 96%379398 Enzymatic degradation of Dopamine by monoamine oxidase 17161 12846 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.4 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects 12578 RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 96%5626467 RHO GTPases activate IQGAPs 19353 12385 544963 640703 12387 12550 56430 17283 404710 29875 MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.4 MASTL Facilitates Mitotic Progression 19052 67121 12534 56205 19053 52432 51792 73699 59046 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%111448 Activation of NOXA and translocation to mitochondria 211586 13555 22059 21781 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669934 Sunitinib-resistant KIT mutants 16590 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 96%8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors 17869 12575 21420 75605 21418 PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 96%622323 Presynaptic nicotinic acetylcholine receptors 11438 110834 11449 110902 11435 11448 11447 11440 108015 108043 11444 110835 SIGNALING BY AXIN MUTANTS%REACTOME%R-HSA-4839735.5 Signaling by AXIN mutants 225849 93687 26931 21770 26932 73699 72345 19052 19053 51792 56637 12005 11789 226849 CASP4 INFLAMMASOME ASSEMBLY%REACTOME DATABASE ID RELEASE 96%9948001 CASP4 inflammasome assembly 640703 66222 12363 DEFECTIVE MMADHC CAUSES MMAHCD%REACTOME DATABASE ID RELEASE 96%3359473 Defective MMADHC causes MMAHCD 109129 67096 HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 96%1638091 Heparan sulfate heparin (HS-GAG) metabolism 15931 14043 14042 15531 15530 27419 103978 54710 628779 54616 58193 50785 14733 545291 70484 83398 50786 23908 15529 11603 23888 20971 93683 20969 14734 64580 15476 15442 15478 27029 195646 71951 17423 20970 328779 14735 50787 319415 15932 CYTOPROTECTION BY HMOX1%REACTOME%R-HSA-9707564.6 Cytoprotection by HMOX1 20459 12866 12865 100041785 20602 216799 17250 333182 17708 17709 20181 17710 19013 56338 19014 380975 229003 84682 670717 15129 15368 15122 12013 21372 109151 17977 17992 17135 17978 59035 14950 81004 66993 18024 15369 11657 15183 20185 109778 233016 106766 12914 56406 12858 14080 12857 20466 20848 110323 12861 20463 12862 12868 66142 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9693928.5 Defective RIPK1-mediated regulated necrosis 56532 74568 22030 71609 14082 12370 19766 PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 96%1257604 PI3K AKT Signaling 233833 13626 268980 18183 83961 320207 100042150 20779 17295 11651 11652 22324 18710 52615 17999 19646 234366 26413 26417 14360 327826 13001 13000 100039026 56233 245688 13649 21802 23942 78757 228775 30955 18708 18709 18706 108083 18607 74769 18707 12487 12519 12524 19354 15183 66508 545987 54170 11909 22084 52187 68576 66096 83409 74370 68441 268706 15234 67605 245670 56484 16476 83490 18596 216848 77647 18213 107932 19211 19712 18595 22059 229542 20613 56424 56212 11798 18718 99982 217864 13866 18720 18719 15370 20393 12575 18854 66894 72607 68031 73162 19720 21951 74493 14302 12576 14255 21907 73699 12015 12371 12418 19052 17192 19053 51792 14013 12151 226849 225849 26931 19763 21770 26932 17246 54383 13619 12223 241915 12416 71920 13874 15200 211323 19821 77125 494448 21762 30951 22123 12064 12675 14388 17082 19179 19181 18212 19182 23996 18205 19184 78405 99377 26440 19166 11839 19167 13645 26441 80903 384783 26442 69077 14186 66997 14165 23997 14389 56436 16367 17463 14172 57296 80857 20422 26445 16334 14170 26446 19172 14180 19173 14178 19175 56458 14177 67112 19177 64654 14175 14174 26443 14173 26444 14164 83379 19170 17874 66413 16179 667035 22190 59029 13983 67089 70247 266632 13982 19016 244650 13498 68877 98432 58988 15937 12478 75778 76850 239528 18591 54601 236511 56717 16337 13653 19353 213988 217351 56637 14256 214150 227743 15184 19247 22034 116871 116870 104709 20583 14056 18717 17454 252870 109270 606496 433759 16818 16590 56716 15182 23797 54484 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 96%983705 B Cell Activation 12234 269717 56436 17463 57296 17973 20422 26445 26446 58194 19172 19173 19175 109305 19697 19177 21402 16150 26443 26444 12483 16151 22324 19170 19696 22063 12042 66413 26965 667035 22190 18751 240354 20866 59029 26409 67089 229709 103583 14360 16438 70247 16439 16440 17096 18176 20662 15461 26377 12478 18708 18707 12143 234779 20963 12229 17060 12518 15985 640703 15170 268373 19055 19056 19419 18018 18019 21762 240168 22123 19058 12675 14225 108723 18021 19179 19181 19182 23996 19184 18033 26440 19166 18035 19167 18036 26441 18037 26442 69077 66997 83490 23997 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.5 Gene Silencing by RNA 233833 232440 319149 94223 192119 23992 53424 21357 22099 15077 66420 69833 67710 245841 69920 74068 20022 210510 74691 15519 57746 20020 98558 231329 83456 20021 330890 69241 72634 71981 17749 13206 100043714 17864 66715 94244 57749 83561 15267 319168 319167 19384 76850 239528 319186 319178 319183 319182 236511 319190 319176 319181 213988 217351 214150 320727 11727 68626 319169 75284 72322 625328 14000 78303 319188 15270 624153 382522 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 96%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 12539 13649 12402 18176 14388 20662 15461 18803 667035 22190 13645 18708 18706 20416 15519 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190242 FGFR1 ligand binding and activation 21814 80857 67903 14180 14177 67112 64654 14175 14174 14165 14173 14164 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 96%69563 p53-Dependent G1 DNA Damage Response 56436 17463 57296 20422 26445 26446 12575 19172 19173 19175 19177 26443 26444 12566 19170 12447 66413 667035 22190 12448 59029 12576 67089 70247 22059 17248 29813 59092 26374 50883 228829 12428 17246 11920 12578 12427 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 REGULATION OF MITF-M-DEPENDENT GENES INVOLVED IN APOPTOSIS%REACTOME%R-HSA-9824594.3 Regulation of MITF-M-dependent genes involved in apoptosis 17364 233833 18992 236511 17454 192119 15254 20466 12047 213988 217351 433759 12043 214150 329581 76850 239528 DEGRADATION OF GABA%REACTOME DATABASE ID RELEASE 96%916853 Degradation of GABA 214579 268860 STIMULI-SENSING CHANNELS%REACTOME DATABASE ID RELEASE 96%2672351 Stimuli-sensing channels 14226 20393 65973 76757 109552 225997 22063 193034 22065 22067 667035 22066 22190 28240 20192 22068 20191 63873 171382 69847 171166 20190 75607 56407 279561 68667 208169 277328 64177 17364 107568 382427 246788 27219 68279 94178 22368 226025 101772 194352 117160 26946 56843 170755 58800 14628 241118 11419 110157 212989 102566 404545 229277 338370 26372 140475 13830 105722 382014 14605 20278 78339 217843 320091 252972 20276 20277 232341 56365 233246 26373 12728 12727 83814 12725 12724 97086 12723 243634 23844 74446 24115 58170 99663 233979 229933 12733 105355 640703 SIGNALING BY FGFR1 AMPLIFICATION MUTANTS%REACTOME DATABASE ID RELEASE 96%1839120 Signaling by FGFR1 amplification mutants PLASMA LIPOPROTEIN REMODELING%REACTOME%R-HSA-8963899.3 Plasma lipoprotein remodeling 16891 270669 30924 68453 103161 11806 57875 11307 238055 105847 18453 11816 16956 18552 18550 66113 18553 11657 11807 11808 16816 56453 17777 56636 624219 15450 76483 11813 11814 208677 ANTIMICROBIAL PEPTIDES%REACTOME DATABASE ID RELEASE 96%6803157 Antimicrobial peptides 19152 246082 654460 654465 244332 629114 12796 18173 66557 11870 22072 11977 21946 12504 19695 12772 17002 18489 12652 16429 18843 19194 329547 12458 12759 54159 78416 228801 57757 242100 11927 50701 72621 259301 228796 75526 384997 20201 20202 13035 77674 16819 24088 654464 21897 266620 654459 75400 246700 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME DATABASE ID RELEASE 96%4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 225849 93687 26931 21770 26932 12387 14367 72345 14362 57265 12389 22416 56637 12005 22423 20890 22408 103236 13542 14296 73699 13544 13543 212398 19052 19053 51792 16974 11789 16973 226849 APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 96%111471 Apoptotic factor-mediated response 670717 12261 69146 12371 11798 12018 12369 56369 12367 11783 12028 54722 74268 72565 66593 26413 26417 12578 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME DATABASE ID RELEASE 96%174417 Telomere C-strand (Lagging Strand) Synthesis 327762 14156 214987 214901 68964 72107 22427 108689 19687 57321 69535 19718 69263 21749 16881 497652 21750 18538 12144 68275 18969 106344 18968 72151 18971 68240 18972 19075 19076 19891 67967 28113 101185 69745 SARS-COV-1 INFECTION%REACTOME DATABASE ID RELEASE 96%9678108 SARS-CoV-1 Infection 20448 56208 16785 19089 67443 78610 66824 216799 22628 19645 12389 269523 12330 100039316 16211 100039592 54401 55948 20115 17127 17128 76846 100040298 267019 67941 18607 328572 57294 50528 70008 69550 66101 19035 28185 268373 71586 230073 66641 18521 14225 228607 217069 56217 18033 18035 22627 12048 75669 56480 20683 54131 225326 19697 18148 667035 225913 22190 67089 100039786 20390 15382 66371 108960 22196 68953 75608 12362 170743 16396 208092 66700 67197 56532 22031 56489 53902 105513 72512 64685 56637 228005 22034 27207 67097 670832 633683 13207 20044 27050 667279 20085 668144 20084 382492 20055 22631 75617 57377 27370 22629 629957 20102 14423 20103 214424 668668 328417 667739 606496 67287 80285 52552 20446 671535 20444 22346 66481 547253 20442 225058 20443 100038875 17308 20440 14376 20447 SARS-COV-2 TARGETS HOST INTRACELLULAR SIGNALLING AND REGULATORY PATHWAYS%REACTOME DATABASE ID RELEASE 96%9755779 SARS-CoV-2 targets host intracellular signalling and regulatory pathways 100039786 22627 54401 22628 22631 55948 22629 23797 12389 11651 11652 18607 DEFECTIVE ALG8 CAUSES CDG-1H%REACTOME DATABASE ID RELEASE 96%4724325 Defective ALG8 causes CDG-1h 381903 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME DATABASE ID RELEASE 96%72203 Processing of Capped Intron-Containing Pre-mRNA 66053 66983 15381 19655 70616 269061 68598 67959 20462 107701 67480 72047 68092 74326 67500 433702 75956 56031 80744 66101 70225 13684 68879 320632 67418 212880 66585 22380 74351 54723 83486 19134 545085 66877 244672 238831 23983 24010 18521 20227 83701 74255 57905 67229 68479 56335 70312 330361 66177 67797 67050 209416 76167 210529 76522 22184 100043168 72654 20222 50996 66899 28035 78372 72886 67225 18949 60321 67178 66492 71715 215051 66618 230596 70052 70767 67922 66070 66381 77644 66810 108160 319322 100034361 66801 237859 19205 68592 27967 68035 217207 76936 67471 69757 24128 68988 208768 71702 76793 22668 68981 67684 20639 209003 229279 227707 101943 81898 67439 94315 20646 192159 53317 15382 53379 56258 59013 98758 11991 11834 15388 15387 66055 170762 108989 231042 68816 227699 223921 227720 269113 50783 67197 66679 67678 18141 54633 107939 66094 67465 69482 71805 69192 54563 78651 27756 19069 67285 70699 66373 236732 19045 72787 67958 18226 68183 218210 76479 20624 66642 19046 75062 27366 228005 28000 13204 100041953 76938 13207 233908 66125 68219 98985 228410 54451 108062 67337 83410 18789 51786 94230 74320 68188 54188 20492 19386 54196 445007 64340 622469 69912 225027 15481 67996 225160 22608 51796 56488 103468 192160 331401 71713 53817 233073 625193 69823 234865 20382 110809 73666 60365 20383 59015 68278 69736 170722 70579 21681 73826 68134 110379 66231 66511 107829 108014 53319 192170 69207 19826 193116 74412 66441 386612 17149 100040029 107686 384091 666609 216578 100040177 67010 68705 20641 98053 667035 20638 22190 66420 69833 67710 245841 69920 67332 20022 20020 231329 20021 72198 69241 17749 100043714 170791 20630 14105 20637 53607 70044 56070 67039 72459 56194 100336 52040 72935 13211 56215 51810 RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%9037628 Rhesus blood group biosynthesis 19746 DEFECTIVE ADA DISRUPTS (DEOXY)ADENOSINE DEAMINATION%REACTOME DATABASE ID RELEASE 96%9734735 Defective ADA disrupts (deoxy)adenosine deamination 11486 ICOS CO-STIMULATION%REACTOME%R-HSA-9927354.2 ICOS co-stimulation 104709 74769 18707 18710 30955 50723 320207 18708 18709 18706 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 96%2033519 Activated point mutants of FGFR2 14172 80857 14180 14178 14177 67112 64654 14175 14183 14174 14173 14164 80903 14165 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 96%9665251 Resistance of ERBB2 KD mutants to lapatinib 13866 59079 12539 15519 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME DATABASE ID RELEASE 96%3769402 Deactivation of the beta-catenin transactivating complex 12234 20679 21415 20682 12387 21414 21416 20671 17283 20674 16842 11798 11651 103573 11652 66310 140858 667035 22190 213464 20668 21885 21887 20680 75410 21886 22631 21888 23808 20675 20677 433759 77578 68911 13016 67772 67087 80288 11789 73739 72135 FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.4 Formation of the HIV-1 Early Elongation Complex 68092 433702 20922 68705 98053 13871 66420 69833 67655 67710 245841 69920 57314 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 58202 17420 12572 13872 27632 20924 24116 23894 14884 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME%R-HSA-9680187.2 Signaling by extracellular domain mutants of KIT 16590 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 96%72306 tRNA processing 107508 70047 19386 19384 445007 67676 102614 69912 103468 234865 72026 72085 67674 59015 230734 69736 68291 110379 70359 76367 67053 108943 328162 233189 240174 76357 74455 208366 229780 227522 66965 209584 68736 30947 54364 13434 100929 54632 68260 73681 68916 66966 28114 66369 67049 57773 17299 100043886 66757 106248 68205 66628 66246 212528 69786 329504 60507 67667 170762 78890 108989 319582 231042 78697 227699 223921 227720 269113 66679 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 52575 66132 15108 76265 68215 66637 74097 68045 73192 104721 68626 117109 98985 66161 381802 66078 108062 28088 67724 67106 98404 94230 54188 BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.2 Biosynthesis of DPAn-6 SPMs 11684 11687 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 96%2559580 Oxidative Stress Induced Senescence 233833 232440 13626 319149 211586 13555 21781 12571 12567 15077 13557 242705 667035 26416 22190 52615 19646 26413 26417 19094 245688 102626 22059 12418 665113 17164 15267 319168 22166 319167 14281 76850 12151 319186 26408 17248 319178 319183 17165 19763 319182 236511 17246 319190 54383 13619 26399 26400 319176 241915 12416 26398 319181 26420 26414 213988 26397 217351 19821 214150 100043858 12580 216850 12579 12578 14056 50932 26921 494448 17454 15977 26419 319169 30951 625328 16476 78303 319188 15270 624153 382522 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME DATABASE ID RELEASE 96%418359 Reduction of cytosolic Ca++ levels 11941 320707 381290 640703 20541 11937 11938 110893 53313 110891 109552 67972 LEUKOTRIENE RECEPTORS%REACTOME DATABASE ID RELEASE 96%391906 Leukotriene receptors 574402 58861 16995 57260 70086 ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME DATABASE ID RELEASE 96%983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 56208 225326 66397 12317 14827 69608 15006 80898 218811 99683 240095 667803 12330 21354 21356 21355 14991 77371 69162 20334 110379 14828 15007 12010 218978 75669 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.4 Defective ABCD4 causes MAHCJ 19300 68421 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME%R-HSA-5658034.4 HHAT G278V doesn't palmitoylate Hh-Np 16147 226861 20423 13363 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 96%209952 Peptide hormone biosynthesis 16326 22094 18976 16325 12640 16324 18548 16323 16866 16322 14308 DAP12 SIGNALING%REACTOME%R-HSA-2424491.4 DAP12 signaling 22325 74769 16643 83433 234779 57257 18176 20662 22177 19353 15461 20963 17444 667803 12229 18803 16818 12010 18708 16822 18709 14360 27007 18706 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 96%190375 FGFR2c ligand binding and activation 14172 80857 14180 14177 80903 64654 14175 14173 14164 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 96%194068 Bile acid and bile salt metabolism 76408 13116 56050 17977 76303 20494 71720 20493 228983 106407 13124 12642 330962 17978 26459 170460 17117 99031 105349 71240 100273 27413 11657 16204 28250 64291 20181 12012 20186 13123 93732 104086 13122 77337 208665 101502 28253 83702 26458 15488 170789 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 96%1912422 Pre-NOTCH Expression and Processing 233833 232440 11937 11938 319149 211586 14595 53313 18129 13555 18131 18128 21781 18132 12443 270118 18759 15077 13557 50721 13710 54613 22059 15267 319168 319167 76850 103806 239528 319186 328572 319178 319183 319182 236511 319190 333639 319176 50701 319181 213988 18550 217351 214150 12914 17454 14534 20338 319169 18519 16848 625328 19664 16476 78303 319188 15270 19719 17305 19346 20443 224143 140484 624153 100042343 382522 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.4 Inactivation, recovery and regulation of the phototransduction cascade 14919 18108 107477 14913 245650 73582 14685 20215 12788 212541 14699 18761 75624 14688 110606 640703 14272 24013 56307 237178 243923 225600 18750 18107 18587 18588 19674 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.4 Early Phase of HIV Life Cycle 23825 268373 14156 12767 16646 15361 101739 12504 108138 319583 22596 16881 14375 12774 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME%R-HSA-162589.3 Reverse Transcription of HIV RNA 268373 DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 96%3656225 Defective CHST6 causes MCDC1 18295 16545 14264 56773 116847 17022 27047 CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME%R-HSA-442742.5 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 18039 14810 11472 19417 23859 19418 14814 12322 12323 108058 12325 26413 26417 20111 640703 13385 53310 13383 110651 14812 18176 20112 15461 67071 18607 MITOCHONDRIAL BIOGENESIS%REACTOME DATABASE ID RELEASE 96%1592230 Mitochondrial biogenesis 216151 15161 12326 381760 26416 29857 20181 19013 19094 26379 108099 18181 14390 19014 68346 229003 11655 14661 226169 670717 15278 21780 21372 109151 241113 17977 19017 60525 17978 59035 81004 66993 17260 17261 224481 208595 70461 15183 227112 20185 17827 57423 217166 68653 74343 66477 12914 76614 382056 224904 56406 11958 11909 640703 11957 68117 230935 216821 11947 66075 11949 433771 68055 75387 108079 68316 17705 19079 11946 15526 269951 20656 108097 66098 66043 11950 53375 100041835 100039108 170826 432676 19082 64384 228033 226153 50776 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME DATABASE ID RELEASE 96%5619036 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) 317750 PI3K CASCADE%REACTOME DATABASE ID RELEASE 96%109704 PI3K Cascade 14389 74769 16367 14172 80857 18576 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 327826 14388 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 18607 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 96%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions 19303 16412 57342 16202 VRNA SYNTHESIS%REACTOME DATABASE ID RELEASE 96%192814 vRNA Synthesis 11545 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME%R-HSA-5579032.4 Defective TBXAS1 causes GHDD 21391 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.4 Netrin-1 signaling 20437 19876 68799 226251 17973 20563 223435 17909 13176 107449 20779 107448 319713 19353 73178 22063 22065 22067 69585 22066 210801 20564 22068 20562 114873 22350 19247 18761 216439 244058 18738 26946 22253 18007 14083 330662 231148 57764 18803 13508 18208 20439 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME%R-HSA-1362300.3 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 13559 75660 104394 12534 12428 211586 13555 21781 433759 19650 19651 19646 17865 72568 231506 629959 COHESIN LOADING ONTO CHROMATIN%REACTOME%R-HSA-2470946.2 Cohesin Loading onto Chromatin 71175 71521 24061 74549 100710 218914 20843 19357 13006 20842 SLC-MEDIATED TRANSPORT OF INORGANIC ANIONS%REACTOME%R-HSA-9958790.2 SLC-mediated transport of inorganic anions 20536 20535 13521 55961 216225 208890 114479 320718 74340 232156 20515 20504 57138 54403 59033 20498 243755 20499 20495 20497 20496 107723 23985 13487 94229 240215 20516 171429 20533 268512 218756 20505 231583 142681 20531 G ALPHA (I) SIGNALLING EVENTS%REACTOME%R-HSA-418594.9 G alpha (i) signalling events 18796 18797 14686 18795 12326 20779 19084 26413 212108 242093 239336 23919 14419 12772 12774 12768 80901 84112 20607 387512 12776 12775 12458 12773 12771 18386 18389 14539 243270 239283 387513 14427 18166 19218 18167 18168 14294 12802 14293 12801 387353 387515 353148 12765 227288 56838 57811 17773 244701 640703 353165 387348 19055 387356 19056 19156 20605 19065 20606 19064 19058 80885 12145 20609 20608 14428 13051 217212 208990 110326 12568 83770 11820 20132 140795 57349 30878 17329 20290 18155 55985 20303 109648 20304 12057 14675 20296 15557 24012 19739 57385 13491 13490 20297 100039973 50782 74191 100038965 14697 13610 56066 12672 50779 20311 20312 15552 20300 14710 11539 15551 14699 66066 18610 243764 14700 18619 11542 14708 66102 14706 14672 13611 51791 15563 330122 14704 14823 67839 225192 108073 14695 268934 14676 94226 19049 108069 67792 108068 58175 14693 20310 18545 14825 64337 353344 18577 14709 14429 110385 14764 238871 13603 11609 14682 23796 83771 67865 14701 574417 71729 387347 57253 12777 57254 387355 387342 626596 387349 12766 226304 76123 387616 321019 12778 14702 381073 106512 110168 14696 436440 76854 12769 19088 15199 14763 19108 70839 19045 12267 171469 104110 227326 14739 14678 12854 14677 16952 15945 14687 14679 432530 210044 104111 19057 14688 224129 11512 11513 11514 11515 18749 20315 242851 19085 12767 19087 53978 12322 12323 108058 624910 12325 246709 19734 229709 16438 16439 18798 18747 100039592 14745 16440 73699 56183 19052 64214 19053 51792 14289 12374 50778 56744 50780 19736 11606 21770 12061 12062 14680 56470 216749 19737 55984 65086 54393 240816 381810 574402 385643 433292 207565 110312 18752 11551 14767 11552 11553 56533 242425 14685 18387 18390 212541 20210 15139 12266 18753 18783 110355 18575 18574 18573 12273 20604 207911 18976 18750 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.4 SARS-CoV-2 Genome Replication and Transcription 13207 22346 19645 67197 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME DATABASE ID RELEASE 96%3296469 Defects in cobalamin (B12) metabolism 93835 17850 54219 109136 68421 238505 65969 21452 77697 210009 109129 67096 14603 19300 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME DATABASE ID RELEASE 96%8937144 Aryl hydrocarbon receptor signalling 11624 11632 11622 11863 100043508 15516 11864 DSCAM INTERACTIONS%REACTOME DATABASE ID RELEASE 96%376172 DSCAM interactions 13508 13176 114873 18208 ASS1 VARIANTS CAUSE CITRULLINEMIA%REACTOME%R-HSA-9956520.1 ASS1 variants cause citrullinemia 11898 67824 TRANSPORT OF ORGANIC ANIONS%REACTOME%R-HSA-879518.5 Transport of organic anions 24059 11998 227394 58807 108115 101488 20502 28250 28253 SIGNAL TRANSDUCTION BY L1%REACTOME DATABASE ID RELEASE 96%445144 Signal transduction by L1 22325 13001 13000 100039026 16412 13649 18186 26395 26396 16410 16399 19353 16416 16402 16728 17967 26413 18479 104099 26417 FIBRIN FORMATION%REACTOME DATABASE ID RELEASE 96%9769733 Fibrin formation 19123 11905 14060 15160 16399 14061 20720 268591 16416 14161 110135 99571 74145 HEMOSTASIS%REACTOME%R-HSA-109582.6 Hemostasis 20779 12389 14786 26416 12928 18754 18126 18755 320127 26413 76192 18787 26417 239273 104418 56077 20416 66082 22325 231871 380921 109905 110524 269060 110197 217480 13139 331374 57257 54519 18176 20662 22371 15461 16416 110157 14161 21894 215449 109689 216869 16452 110135 99571 22330 15129 109711 242202 11806 54216 56760 11852 238055 17135 22365 21390 14673 640703 268373 19419 14674 20501 12215 15234 22041 210293 12568 63955 11820 22390 13449 26934 14697 14710 14699 66066 14700 14708 14706 14704 14695 14693 64337 14709 14701 14702 17075 14696 16363 21933 19088 234779 20963 14678 14677 232345 14679 11657 217864 14688 18438 68117 15353 17319 18788 14191 18749 18439 67414 170731 242851 67299 19085 269717 11931 11932 11933 11937 11938 53313 109305 18793 109552 12566 67972 11941 320707 381290 16531 16533 20866 110891 16331 16438 73470 16439 16563 18747 15529 23888 11640 20971 217837 20541 12491 18125 110893 20969 16440 73699 18436 228139 18440 12527 94045 231602 19052 71951 73804 20970 19053 51792 14735 12505 76088 226849 225849 26931 21770 26932 15530 229841 18693 103978 17134 14733 667310 57274 15977 21912 80879 14734 208869 78287 18752 18803 17289 14828 19128 13645 14456 228421 19152 16069 240641 269152 16565 16564 16552 16580 16581 16561 13660 16562 68732 108829 16558 20399 70218 56697 15135 75050 252966 16554 17133 286942 15132 11603 56248 16578 259300 319991 57440 171580 16560 14464 16409 83964 16423 16411 16414 67374 105722 11674 53896 14465 30962 233246 19353 50934 19247 104709 20540 330836 15170 17254 16569 20539 26570 625328 16818 18750 17136 19092 14066 16570 217847 319149 320207 11472 19084 22612 15160 11651 22324 15077 20194 18710 20725 20719 18791 18792 20737 66053 12419 14360 12988 16568 16002 16000 14723 17096 16784 21825 16362 30955 18708 18709 18706 18607 74769 18127 14462 19222 16594 668303 16579 14461 232943 14460 19348 14463 71819 16593 16551 110033 19354 16149 209737 74764 19156 19123 100163 22363 12481 271457 20339 69524 19261 108078 17863 12523 22364 20343 72017 20345 57349 13052 20340 64435 270152 71683 16456 12506 18762 16923 58217 11848 171486 58802 18106 23921 14675 11905 72413 68813 14672 16572 16573 16412 23984 241489 14676 22145 22059 94176 330662 207728 14682 19246 238130 14724 268936 192176 435726 54368 14729 56212 23945 54195 70839 60596 234889 99982 20909 12343 12345 12340 21857 12306 16410 16571 14083 21803 21808 16728 22761 21809 74947 279028 19087 12331 18643 213119 11350 18441 58992 16621 56744 14064 14062 22762 14061 83995 14065 385643 11551 11552 11553 16822 16797 75974 14068 319899 109700 22065 16398 16400 16403 14058 18751 22068 14071 66901 16408 106722 26946 14127 243816 18753 14726 18783 18574 18573 16399 14268 16401 16402 11818 27359 12258 21346 56508 223864 20716 227290 19363 18591 18022 117586 109232 21687 71946 11600 12759 215789 235505 67988 11537 12321 18613 26968 68038 114714 20912 20911 18585 21922 17540 20255 108101 21824 218454 14060 223601 109821 12512 20720 12927 268591 80718 19124 16426 20597 22138 68891 227612 60595 104009 320202 70945 53612 67059 18761 20703 11625 21767 19395 19073 56541 74145 14067 12631 14205 11601 21832 50915 17480 11602 80884 20344 21859 74840 94175 13041 22631 20363 11747 16427 18815 56193 18816 20466 19039 56055 13601 240334 14069 20692 433759 22388 75396 22341 18407 22339 22340 11804 71660 15182 67072 66866 27999 DEFECTIVE GNE CAUSES SIALURIA, NK AND IBM2%REACTOME%R-HSA-4085011.4 Defective GNE causes sialuria, NK and IBM2 50798 CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.13 Cellular responses to stress 52717 99152 668450 56494 15901 67443 20602 20867 26416 26413 26417 20416 19094 102626 17164 11518 21894 71853 20818 107513 68090 78943 19014 77128 229003 26427 11865 208647 19377 15516 381801 70804 27362 52466 27053 328572 12915 15129 320209 17087 78284 15368 64209 15122 22393 12013 15191 56444 21372 52639 67665 109151 72599 22428 11806 13191 56760 192193 17977 74322 12344 238055 12611 19017 71765 59288 18143 22642 103573 28106 17135 28146 17978 75766 59035 231997 81004 12751 66993 56219 17260 67398 17261 12913 21898 52808 12753 242341 105785 18024 68775 268903 70461 15369 15183 20185 66508 76252 93759 545987 11972 217166 108664 74343 66290 12914 382056 54170 56406 11909 11964 52187 26357 68576 110935 66096 11966 83409 100039636 74370 66335 68441 11973 11974 268706 74915 67605 338375 245670 20656 73834 56484 16476 114143 66237 18477 21672 16906 22627 27060 67838 66144 20459 270669 12282 20683 18044 18045 18046 17969 18128 56438 13856 230099 13058 13057 17970 17972 56453 217365 213539 670717 22230 56445 18453 16175 11657 26554 208677 15526 15926 12575 211586 216799 13555 19645 21781 12571 12567 12566 13557 12447 12322 242705 12323 56371 108058 27401 12325 12448 12034 12576 66592 27377 234663 19386 110651 20112 12418 68097 15364 665113 28113 77683 101185 15260 22166 29817 75560 56702 50709 14957 50708 445007 14958 20657 12151 14630 26408 76408 225849 17248 66401 17165 14780 19763 14778 80838 14775 66403 26462 12428 67305 57294 17246 12460 56455 54383 11833 13619 11911 110147 26399 11927 57321 20293 26400 69590 241915 76650 12416 17436 26398 75221 26420 50527 26414 14950 26397 17134 13875 27407 319152 75512 104248 54616 68350 19821 56551 18104 21749 58193 11758 497652 14859 21750 11757 23939 140742 100043858 224111 12580 109778 69912 216850 233016 12579 71389 12578 106766 16193 667310 23872 14629 103468 23871 50932 26921 494448 15977 235661 26419 12427 234865 170644 12608 30951 59015 69736 21351 110379 13427 11839 14828 12043 18590 13426 13645 12048 13424 21881 17250 18759 110208 11977 15267 66839 64704 319168 58233 15502 319167 18181 14281 13665 74142 67204 76850 26905 15512 319186 15482 319178 319183 319182 16905 236511 319190 50758 56717 319176 69654 319181 213988 217351 226641 56637 214150 13819 14056 101543 112407 17454 112406 29806 319169 319594 26570 108079 54130 20848 625328 78303 606496 319188 15270 56716 624153 23797 382522 233833 232440 13626 319149 13666 11651 11652 15077 269523 52615 19646 11910 13001 13000 100039026 17869 245688 74126 15251 53417 50493 228775 53598 66362 109075 66583 27998 72544 50911 69639 72662 66446 227715 74108 14776 12857 67923 110323 12861 12862 12868 66142 12866 12865 100041785 333182 15510 22059 628438 170762 108989 380975 231042 227699 223921 227720 269113 66679 18141 17684 107939 69482 71805 70640 16475 54563 19069 17992 15361 70699 72787 18226 218210 50490 14229 11370 14228 27207 67097 670832 633683 20044 27050 12343 667279 14080 12345 20085 668144 20084 67186 382492 20055 12340 75617 100043508 27370 65019 629957 20102 20103 668668 667739 672214 64384 66481 71745 225058 100038875 100038991 68028 100043000 67891 100043295 622534 238217 17872 16785 666669 100040021 67025 100043391 668182 241053 12317 432502 19989 76808 19899 100043184 19921 19934 100043755 66105 193740 319195 100043209 68193 621100 19941 665189 666899 12955 100042670 15499 15519 72630 100039316 56354 22121 50497 17168 12017 216805 81489 101142 70356 230676 67669 27103 100037258 219158 270802 100043876 29810 98402 100043893 18415 268933 100043423 110920 56032 100042986 67384 72124 20115 66538 16210 67281 14583 70369 71962 23950 216742 76846 15525 319481 625646 15505 231659 100040298 68196 101148 68172 22791 277854 100042740 80888 252875 19951 73442 70394 69065 667618 100040970 267019 56040 67248 100040331 67941 18412 15481 12858 21762 13198 22123 19179 19181 19182 23996 19184 18033 230784 26440 19166 20463 19167 26441 26442 69077 66997 23997 12234 14381 56436 17463 57296 20422 26445 26446 19172 19173 19175 19697 72345 19177 15467 21402 107503 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 17708 20181 17709 17710 19013 13982 19883 11835 18753 14815 20821 110784 18667 19360 56338 17535 22027 12359 84682 27354 81601 14783 11920 16006 12189 228998 15185 100041766 11863 66515 68275 67013 69162 20111 68240 233826 50868 19891 20466 217232 56317 59008 66156 216080 69957 17222 22346 22339 75430 68612 52563 22194 68999 52206 100039535 50907 DEFECTIVE MMAA CAUSES MMA, CBLA TYPE%REACTOME DATABASE ID RELEASE 96%3359475 Defective MMAA causes MMA, cblA type 17850 109136 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646303.4 Evasion of Oncogene Induced Senescence Due to p14ARF Defects 12578 DENGUE VIRUS INFECTION%REACTOME%R-HSA-9839923.2 Dengue Virus Infection 56208 69940 67443 12387 13200 74153 319149 22201 107338 74244 15077 269523 22088 17096 171210 15381 18005 231380 78757 19298 22352 70233 18708 18107 218978 19655 73075 15516 70616 269061 66892 68598 67959 17087 66357 17395 100040603 232989 107701 11806 67480 66286 72047 68092 74326 67500 56298 103573 433702 18452 75956 66861 18550 56031 80744 21898 218490 66270 70225 69019 18451 13684 68879 320632 67418 208643 212880 66585 74351 83486 216705 74370 71586 66877 56529 23983 18521 228607 83701 217069 57905 68479 16834 13690 15569 209416 20222 66899 320452 67838 60321 17713 66070 23845 66810 319322 12282 233726 19205 27967 76936 170786 71702 68981 20639 229279 235623 101943 81898 67439 94315 20646 192159 11993 53317 15382 53379 56258 59013 98758 11991 217365 11834 20168 15388 15387 18571 66055 68816 81910 230861 19766 213539 22230 24127 54633 67465 66624 56445 69192 16646 14827 67285 18453 236732 223697 67958 68183 11771 76479 11772 20624 66642 71770 20847 68137 75062 77134 21349 27366 76687 13205 28000 13204 76938 13207 233908 66125 232910 11773 68219 98985 228410 54451 108062 110611 67337 83410 18789 51786 94230 74320 68188 54188 18458 16785 12317 19899 12322 12323 193740 108058 12330 12325 13163 192292 15519 15529 216965 23888 20971 16211 100039592 16648 100037258 20969 54196 13480 13481 71951 20970 381686 16649 14735 68563 14104 15530 171283 14061 103978 14733 64340 622469 76246 225027 15481 67996 214498 22608 51796 66317 71713 233073 235497 14734 22083 20382 110809 20383 54624 21681 17069 68032 17289 14828 18035 19128 108014 276891 18036 217303 192170 22174 69207 14456 19826 75669 26362 17533 100732 52898 12737 100040029 225326 107686 384091 13682 666609 13681 21872 68705 20641 98053 667035 20638 22190 66420 69833 67710 245841 69920 67332 20022 20020 11603 231329 20021 69241 625018 17749 100043714 69116 22196 621893 15568 319162 15267 319173 319163 319168 22370 319167 319186 317677 319178 12759 319183 319182 17195 319190 12259 12475 56489 56717 319176 319181 20014 72512 103963 13211 69038 214763 227743 13135 51810 22200 319169 109270 67075 66663 78303 319188 319189 80286 56716 68292 19092 16430 382522 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME DATABASE ID RELEASE 96%389661 Glyoxylate metabolism and glycine degradation 100042811 268782 18293 78920 14711 14719 11611 56189 67432 212647 104174 68133 19301 76238 13142 13382 70503 434437 15112 SPECIFICATION OF THE NEURAL PLATE BORDER%REACTOME DATABASE ID RELEASE 96%9834899 Specification of the neural plate border 21415 14472 12387 12159 18505 21420 21419 20674 14175 22416 17701 22771 18509 18999 17863 21418 13395 NEUROFASCIN INTERACTIONS%REACTOME DATABASE ID RELEASE 96%447043 Neurofascin interactions 53378 12805 11733 13193 53321 319504 269116 DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME DATABASE ID RELEASE 96%5579015 Defective CYP26B1 causes RHFCA 232174 DEFECTIVE PNP DISRUPTS PHOSPHOROLYSIS OF (DEOXY)GUANOSINE AND (DEOXY)INOSINE%REACTOME%R-HSA-9735763.2 Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine 18950 MACROAUTOPHAGY%REACTOME DATABASE ID RELEASE 96%1632852 Macroautophagy 93739 22241 56208 67443 78610 21821 74244 269523 66105 22334 22333 18541 15499 22335 15519 13001 13000 234663 100039026 12638 11520 68097 26369 57320 108099 218978 52639 56455 666468 77040 18412 73683 213948 66840 228361 51897 64930 57436 235040 12421 66508 68118 545987 54636 242557 15481 66795 66169 67841 54170 66615 28185 100043869 74781 22084 52187 68576 66096 235661 83409 74370 68441 268706 53333 245670 66119 13427 13426 223696 13424 75669 68943 56480 225326 67526 11793 68146 100756 66734 72018 17966 19305 245860 667035 22190 66371 68953 75608 22195 50873 208092 66700 241113 56717 71648 11920 105513 15185 100041766 66905 66410 93765 66589 13819 97287 105787 108079 19079 74302 108097 56486 67414 19082 56716 170731 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME DATABASE ID RELEASE 96%8849932 Synaptic adhesion-like molecules 19280 14252 53623 14799 14811 13385 14810 53310 14802 13383 14812 14814 19268 14813 20168 14251 233067 70530 225875 DISEASES OF PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-9759785.2 Diseases of propionyl-CoA catabolism 17850 109136 RESPONSE OF ENDOTHELIAL CELLS TO SHEAR STRESS%REACTOME%R-HSA-9860931.1 Response of endothelial cells to shear stress 12387 12562 19697 19087 19084 16150 11651 16151 14697 54598 14710 63873 14699 66066 14700 14360 18747 11350 14708 14706 14672 18442 14704 16412 14695 22601 73699 14693 64337 14709 16416 19052 16402 14682 78757 21894 14701 51792 19246 54409 18709 18706 22330 18607 74769 11535 18707 14702 18613 14696 18127 19088 56489 56717 104110 109333 227743 432530 55991 210044 104111 14688 640703 224129 109270 11512 11513 11514 71978 12675 11515 12306 20846 16410 12334 18749 14083 12336 18033 69543 17387 16542 14257 18035 56716 19085 DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.5 Disorders of Developmental Biology 18747 640703 20602 12326 21372 23808 20466 81004 66310 433759 140858 56310 15183 20185 213464 381022 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME%R-HSA-450321.4 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 68652 107607 26419 26400 108960 26398 16151 26420 26414 192656 16179 66513 93765 66589 26409 22034 257632 66724 METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 96%196757 Metabolism of folate and pterines 108037 108156 100039707 17769 20509 69906 13361 17768 270685 20425 107747 216188 665563 14276 52466 DEATH RECEPTOR SIGNALING%REACTOME%R-HSA-73887.7 Death Receptor Signaling 22241 12633 20663 22324 66105 18049 22325 12015 67384 57257 20662 17164 16800 13605 76580 12070 24105 213498 207212 71704 234094 56349 16801 94275 19418 75547 18053 72754 18412 69632 213649 24001 224014 230098 53972 30938 15183 77669 442801 226970 54126 101497 67733 269608 328967 14163 26382 26419 268739 14674 66552 73341 76686 432940 20598 12675 52440 58994 18201 21844 73218 18033 18035 22627 12125 236915 109934 14103 56480 11848 102098 11491 19697 16150 16151 12367 18759 14694 192656 277360 17874 192662 16179 53376 667035 22190 26409 622434 545156 16443 21937 30941 19164 14102 17207 22029 19165 12366 229603 22258 100042305 268749 208117 106025 59287 21926 74256 100039623 263876 21929 22195 22035 109904 230972 12370 19766 11797 22030 223435 56424 21933 56489 11796 11798 71648 19353 100041766 71609 56321 14082 66513 22034 72843 66724 68652 433759 216080 15182 17136 68585 18377 235402 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.3 Defective F9 variant does not activate FX 14069 14058 14071 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450385.3 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 72544 50911 24127 69639 72662 66446 227715 70640 75901 54401 11651 12192 17164 66362 109075 66583 27998 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 96%9616333 Defective Base Excision Repair Associated with NTHL1 18207 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 96%8948747 Regulation of PTEN localization 19211 667035 252870 18854 22190 17999 11798 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.5 Formation of the Early Elongation Complex 68092 433702 20922 68705 98053 13871 66420 69833 67655 67710 245841 69920 57314 20022 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 58202 17420 12572 13872 27632 20924 24116 23894 14884 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.7 The canonical retinoid cycle in rods (twilight vision) 70061 79235 98711 19682 102294 20897 19662 216454 15485 17252 27400 77974 241452 19661 19659 212541 19892 22139 17921 235033 11304 19771 FORMATION OF INTERMEDIATE MESODERM%REACTOME DATABASE ID RELEASE 96%9761174 Formation of intermediate mesoderm 17300 14234 12159 18510 16869 18504 14173 23967 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME DATABASE ID RELEASE 96%380270 Recruitment of mitotic centrosome proteins and complexes 20873 68121 12534 78887 22628 225745 231123 227613 74360 22153 18536 22142 66296 214552 18541 75786 15519 18747 71909 237222 22145 17997 18005 73738 68475 51792 53598 208518 236266 100986 12009 99100 103733 22154 74470 104318 56455 101565 19088 16328 219103 230376 69654 259279 83922 171567 51885 75296 26370 76789 72083 12537 76707 233276 103768 74237 219072 13589 225659 18472 76478 78177 28135 214444 76816 54130 18817 381644 13427 22627 13424 27373 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%R-HSA-3642279.3 TGFBR2 MSI Frameshift Mutants in Cancer 21803 21813 FORMATION OF APOPTOSOME%REACTOME DATABASE ID RELEASE 96%111458 Formation of apoptosome 56369 670717 11783 74268 72565 66593 12371 26413 11798 26417 ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.6 ERK1 ERK2 pathway 16451 12534 208884 18039 18183 14810 83961 11472 100042150 20779 23859 14814 17295 109880 216148 26413 26417 14360 29857 12988 20416 327826 109905 20418 13649 19730 21802 54401 26395 194231 26396 54519 29875 18176 245684 20662 22371 16416 15461 75590 110157 231474 23980 18218 14161 63953 21894 13537 215449 19252 11836 240672 109689 216869 26403 72399 18708 18673 18709 16452 110135 99571 18706 22330 16706 74769 14587 14586 19197 14588 19262 545987 640703 19419 83409 240168 15234 18188 18596 11876 56438 18582 56327 16184 16183 19713 19060 13385 18595 70686 53310 13383 16453 54721 19046 13866 110606 26554 226525 14272 18015 320484 211255 240057 101809 54153 114715 114716 19414 69601 19415 14083 218397 114713 16188 16185 12984 12982 16192 16191 20739 20740 640524 20742 20741 20743 12322 12323 108058 12325 16186 14255 17967 80297 320139 56705 19047 73699 19052 19053 51792 226849 225849 26931 14573 21770 26932 12223 19417 19418 71920 13874 15200 211323 14585 16193 18777 21762 22123 14812 19179 19181 19182 70178 23996 226016 19184 107971 19671 436004 26440 216169 16653 19166 11839 19167 13645 12981 26441 12048 80903 384783 26442 69077 14186 66997 14165 23997 56436 16367 17463 14172 57296 80857 20422 26445 14170 26446 19172 14180 19173 14178 19175 14177 67112 19177 64654 14175 14174 26443 14173 26444 14164 83379 19170 66413 667035 22190 59029 16194 67089 70247 57295 16399 14268 235584 67603 319520 19731 18611 18591 70727 21687 11600 19732 17532 76089 171463 56392 67836 71746 14256 19247 18761 233046 17169 57437 16590 19092 KEAP1-NFE2L2 PATHWAY%REACTOME%R-HSA-9755511.5 KEAP1-NFE2L2 pathway 67443 12575 13666 11651 11652 269523 27401 13001 13000 100039026 17869 50493 22166 20657 14630 76408 328572 15368 12013 11911 20293 76650 17436 17135 75221 17134 18412 27407 68350 18104 18024 14859 140742 224111 71389 12578 12914 14629 26357 21762 22123 19179 19181 19182 23996 21351 19184 18033 230784 26440 18477 19166 11839 12043 19167 18590 13645 26441 12048 26442 69077 66997 23997 14381 12234 56436 17463 57296 20422 26445 26446 20683 19172 19173 21881 19175 17250 72345 19697 19177 18128 21402 56438 26443 26444 19170 18759 66413 26965 667035 22190 59029 67089 70247 110208 18753 20821 217365 22230 50758 12189 56637 26554 50868 233826 26570 108079 15926 23797 REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 96%888593 Reuptake of GABA 232333 14412 14411 243616 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME DATABASE ID RELEASE 96%5579020 Defective SLC35D1 causes SCHBCKD 242585 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.3 RHOH GTPase cycle 207425 56320 214230 56374 106326 12389 210998 22319 241656 269523 192662 20514 386649 11857 13171 14570 72565 19349 70584 66508 12988 229658 19877 238505 74734 16818 14467 19878 13830 224105 16480 218756 22637 22042 18479 22143 56784 TGFBR3 REGULATES ACTIVIN SIGNALING%REACTOME DATABASE ID RELEASE 96%9839406 TGFBR3 regulates activin signaling 21814 11480 16323 16322 PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-HSA-212300.4 PRC2 methylates histones and DNA 319178 319183 319182 232440 13626 319190 319149 319176 319181 15077 17765 14055 21652 74016 16468 52615 103551 19646 14056 13436 13435 245688 13433 319169 11569 625328 15267 78303 319188 319168 15270 319167 624153 319186 382522 DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.4 Defective ABCA3 causes SMDP3 27410 RAB GERANYLGERANYLATION%REACTOME DATABASE ID RELEASE 96%8873719 RAB geranylgeranylation 270160 56382 19326 69834 19328 12663 19332 12662 328778 11891 67295 19329 19349 59021 224624 242681 53869 69908 76338 19340 226422 19339 19376 53868 56187 19352 76877 58222 19244 17274 75985 80718 19324 19325 68328 68365 72433 19335 106572 19342 19336 67790 19341 216344 67844 270192 77407 19345 19337 271457 19344 19334 319642 19346 235442 19331 19330 76308 19338 217371 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME%R-HSA-8941333.2 RUNX2 regulates genes involved in differentiation of myeloid cells 12400 16854 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME DATABASE ID RELEASE 96%8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 50933 22201 22209 22225 53323 22284 109161 22193 22213 667035 100041766 67128 22190 216150 22214 67615 268470 252870 432940 66799 231380 216080 67196 22195 68612 22210 22194 100039535 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 96%5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 232910 11773 14367 57265 22418 11771 11772 71770 26563 67300 26564 12757 74325 ENHANCED CLEAVAGE OF VWF VARIANT BY ADAMTS13%REACTOME DATABASE ID RELEASE 96%9845619 Enhanced cleavage of VWF variant by ADAMTS13 279028 22371 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-611105.8 Respiratory electron transport 67876 68267 66690 76826 69702 66278 208501 54405 17991 66091 69487 108755 66272 239760 68015 66414 67388 66379 68472 104130 75597 66928 15159 68493 76947 67044 67273 68198 66495 67130 66416 68375 66108 52892 66836 68342 76178 66377 68197 227197 67184 100042503 66046 230075 66916 66218 69089 226139 14719 14718 70316 17721 17722 17716 17717 17718 17719 67105 12858 12857 68033 12856 110323 12861 20463 12862 12868 66142 12866 67264 12865 100041785 22273 66694 100042918 66576 14297 67530 544717 56046 100040287 333182 380840 17711 22272 66152 624814 75530 67267 66821 56384 26940 100900 17708 72795 17709 107197 17710 66445 110826 67003 68202 380975 84682 670717 17992 229211 225887 72900 226646 17995 595136 623286 66706 235169 78330 67899 210582 66359 52469 66349 76916 69802 75406 15526 66945 73694 66343 66841 94281 66052 67680 66925 110842 71803 67863 70207 78830 231430 50799 20930 17449 66271 17448 SIGNALING BY NOTCH4%REACTOME%R-HSA-9013694.3 Signaling by NOTCH4 56436 17463 16449 57296 20422 26445 11487 26446 54485 19172 19173 18129 19175 19177 18128 18132 21402 56438 26443 11651 26444 270118 19170 66413 26965 667035 22190 59029 67089 70247 15213 15214 17127 19164 19165 15208 100042305 208117 59287 100039623 103806 328572 333639 21335 12914 14534 18519 22631 21762 22123 15205 19179 19181 19182 23996 19664 19184 26440 19166 14257 19167 26441 26442 69077 66997 23997 METAL ION ASSIMILATION FROM THE HOST%REACTOME DATABASE ID RELEASE 96%9638482 Metal ion assimilation from the host 15129 15122 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 96%211945 Phase I - Functionalization of compounds 17161 109731 13075 244209 69574 68021 11670 13849 20186 237940 13123 104086 11754 13122 67758 109857 18105 212503 67247 66112 15516 13087 13116 13107 436059 14261 13115 13106 110115 622127 56050 11624 18984 11622 72303 107141 17977 13088 13077 56448 13076 13114 74134 17978 72082 13110 13113 545817 13070 19224 66427 320997 76507 13120 631304 13118 72054 208285 64385 21391 19223 13124 13121 55990 14262 20181 104158 11668 102294 68165 14149 14148 13082 13081 13072 60525 72535 232174 13079 11529 68738 546726 11522 26876 71519 11532 106648 11669 13909 100040843 13078 11863 11864 11632 100043508 18976 109754 TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.3 Transcriptional Regulation by E2F6 19763 17187 13626 19361 211586 67057 13619 13555 110147 21781 241915 12189 56353 19821 225182 52615 29808 22294 20135 19646 12419 50496 12545 14056 245688 71041 12417 12649 11783 77683 13831 214669 12151 22658 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME%R-HSA-1362409.6 Mitochondrial iron-sulfur cluster biogenesis 14149 14148 14297 380840 74316 73046 246696 67712 100900 68165 ACYL CHAIN REMODELLING OF PS%REACTOME DATABASE ID RELEASE 96%1482801 Acyl chain remodelling of PS 18778 14792 18783 329502 218121 271844 18779 26971 74486 99010 225845 26970 26565 18784 79196 18782 237542 78390 66350 85031 SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-HSA-1660661.12 Sphingolipid de novo biosynthesis 67260 227102 268656 228677 93898 242083 17250 70750 76303 30960 71949 75292 66612 101540 67630 103236 26357 76893 66427 432628 74442 66183 338521 20773 545975 241447 104725 66844 56632 20698 56491 18760 70059 13244 208449 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.4 Disorders of Nervous System Development 18747 81004 640703 20602 433759 12326 21372 56310 15183 20185 20466 METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.12 Metabolism of proteins 17342 56208 107508 22094 12640 15925 51798 171210 15381 109331 12848 216233 12700 100043806 26891 66286 18550 21812 21813 75705 69019 13685 13684 28185 208643 68441 56529 22318 20907 11789 20505 20531 66397 69608 218811 99683 192156 56453 77371 20334 20390 217365 15387 22195 50873 17002 19766 11797 22230 22030 66624 108155 11796 14827 68137 76687 227112 11957 11947 11949 17705 11946 15526 432676 99375 22210 72584 11847 58186 13194 67561 67711 76843 66341 26885 109113 223701 100040573 67241 66647 67872 65973 67040 320213 20230 56459 50995 55989 68501 226026 17190 75826 223870 224903 21973 21974 21969 18747 12418 22166 29817 12151 17248 19763 12428 17246 54383 13619 241915 12416 75221 68350 19821 224111 12578 16193 12427 30951 11839 13629 67160 66656 55949 13628 11487 12266 625018 76768 13665 67204 108067 217715 26905 13667 209354 224045 26374 20617 103534 57377 100042651 70546 108687 269181 19341 217664 77407 107895 19337 20446 20444 74105 20442 20443 260302 17308 235442 17158 20440 67569 14376 19338 20447 53618 20448 227619 19089 19326 106039 12419 16002 16000 21849 21802 74126 67731 218214 21825 214669 71147 56454 53895 270166 320183 27361 76467 110265 18537 12702 14462 14463 15258 14308 14534 12857 216848 12662 18148 53376 19211 230899 11540 18619 66494 15510 22658 17283 69076 16866 57743 53421 100043039 66212 12343 12345 18519 12340 21857 16323 16322 268977 22632 20750 14479 18854 56207 84092 110616 11816 66105 22130 17125 17126 17127 17128 66313 17131 16600 22284 56456 12858 107986 69260 16334 223499 17708 17709 17710 235505 56187 54601 12321 19352 20255 16009 16006 80718 104009 70945 11625 252870 212712 18815 20878 20466 75396 11804 15182 71393 110962 15161 75302 68837 22223 50933 20602 17425 71599 228790 12005 240087 56233 224139 21420 21419 14161 207958 71853 20818 109689 107513 216869 99571 22393 13191 192193 67398 105785 18002 12870 22041 71902 13171 13382 66124 30941 229603 22258 74256 21929 12836 68453 100102 18453 66113 11657 11807 11808 12984 12982 272411 231050 78754 333424 210004 108760 71685 26887 14426 108148 171212 232984 108105 241391 14595 207839 233733 15275 108150 212996 97440 654821 72077 50935 271786 14537 67909 108902 69597 66865 68514 22334 22333 27377 22335 15529 69029 234847 14422 54613 12159 15530 56336 56386 235504 19325 68328 68365 231727 14734 57370 53418 56375 268510 20845 227327 53625 21923 14118 16846 56737 320438 208624 102580 24070 208211 381903 13478 328370 22031 56489 14465 72535 11669 15108 116870 106021 17390 14423 381677 24108 102323 54638 100737 73828 66199 56468 230796 415115 80913 27784 114893 54607 99311 71991 28199 74106 78309 76863 240263 66498 52245 98193 64658 434130 66419 17846 64660 320808 78523 79043 94061 66200 623346 14155 102060 53417 50529 76501 233870 242418 100040519 69456 68565 59043 99045 14154 66973 12238 69163 68842 52443 66398 69089 75763 66077 233805 68611 234664 94062 74251 67212 64656 66845 66407 100042811 27397 67994 69527 121022 64657 66448 77721 66258 57837 14548 232536 56280 66493 353242 67681 66399 64655 107733 68537 18100 67707 94066 60441 218506 66230 68463 65111 74600 107734 107029 66242 28028 68735 622268 27398 94067 28030 67840 68836 79044 68263 94065 228026 57312 75398 68572 67308 64659 56282 66292 24030 66121 66163 68499 18597 18120 107732 27393 66047 69956 216767 56284 118451 59054 94063 235339 66223 11848 17228 11905 21810 68396 12307 56224 69592 13010 20219 67847 16432 20660 23821 232670 51788 19349 17304 22139 624814 52588 70423 56418 70361 104158 13809 16572 66251 16573 12922 69048 57394 14943 16574 234155 18548 27226 17380 12876 16790 76703 16326 12873 16709 70495 11421 100038824 16325 16324 239436 12591 18549 236781 13482 67475 56389 108037 21780 110119 11842 69080 331026 29858 54128 27410 14853 16392 170822 71745 225363 18458 13138 14852 14314 67311 225742 236082 107652 26938 20451 19703 245847 227697 20445 20449 54342 19025 50798 66174 57357 50877 56174 14583 13480 14584 234730 13481 22122 241230 75540 228368 66248 24060 240119 218138 20454 109785 52014 12764 20450 57170 69064 94181 74091 68563 67422 20452 18010 241159 23956 216197 70008 83995 18412 77125 11840 15481 64138 67768 108645 67674 11551 11553 64654 117589 78541 69299 233902 50760 235320 242521 209239 74492 66799 72194 15204 77038 69706 217194 226541 65257 78913 242785 56791 211949 233040 231672 231863 101358 12449 224023 109161 22193 71538 67455 14794 217217 71999 269529 17155 83962 17156 230654 230815 635668 66515 13177 269514 78889 68431 230904 71865 380928 50868 207215 72433 22200 627648 75717 106572 67921 22192 67790 142688 243574 216344 67844 74646 448987 22346 228003 19330 212919 20439 20437 270160 19823 22201 19328 22209 12663 53323 70620 330369 66853 140499 50788 22213 67128 22214 101206 67615 268470 230903 66772 208372 76454 65247 65255 84585 142687 78910 231380 65256 70392 225055 11655 232539 14151 231670 56444 67665 69754 22428 77113 12344 207952 59288 320118 30843 68854 76294 72323 399566 68098 214931 13016 13436 13435 13433 100042305 208117 59287 100039623 18970 17918 73582 13035 11541 242851 216799 72607 68031 73162 19720 21951 74493 14799 18195 18508 192656 20210 24110 257632 107607 231130 59025 69654 17274 53413 11843 20336 107371 54130 16008 105504 16005 66940 211446 208659 13602 16007 16012 102058 16011 16010 246228 13801 12653 11698 20254 56047 19672 94111 13406 30060 15464 69940 11704 71421 217847 18491 107338 77583 105348 80752 23850 16852 18220 15160 66482 626834 20856 66848 338366 83554 11576 66557 98170 17182 16425 232146 12155 76453 74761 53869 100683 53598 104318 101565 13036 26370 217869 226982 66967 223455 66597 108123 320011 108124 23802 22644 66435 76332 75841 16834 270192 319642 102339 19346 338337 17957 67542 56382 69834 97484 233824 17711 22272 67003 20226 13033 99138 13207 20739 20740 11733 11735 640524 20742 20741 20743 80297 12038 11423 19339 22224 56505 225280 242362 26893 56249 69714 227195 109275 26894 68142 108679 233875 70020 19358 19359 235134 22591 26572 21762 432940 22123 26895 67041 19179 19181 19182 23996 110446 19184 15360 19671 436004 26440 71911 19166 18035 19167 71941 70120 26441 381314 67417 26442 226153 102436 69077 74776 66997 109093 23997 212679 12234 70560 56436 71984 17463 224805 57296 353172 20422 70791 26445 68915 26446 230577 19172 226539 19173 381760 71807 19175 69955 19697 13682 244141 19177 13681 21402 27979 56347 26443 13669 26444 53356 16151 68135 19170 55944 66085 12042 73830 66413 16341 26965 223691 667035 22384 22190 54709 100042807 98221 59029 66235 26409 67089 68251 103583 20184 70247 269582 22260 20181 70681 22337 70238 19013 27223 56469 19365 13982 22025 107976 19883 210766 11835 18227 14815 59004 20610 208727 19016 22196 71974 100043429 621893 110784 26423 319162 19401 319173 229615 319163 21834 18667 22027 12021 22427 19090 12189 20388 67091 18538 20703 66226 74143 19324 12144 105522 243819 68275 14067 67013 69162 14275 12793 67857 100042773 233826 20333 215474 207352 74498 66682 52036 76983 13032 245828 12794 240667 67727 214895 59005 14069 78232 216080 56041 333883 21787 27096 67269 68612 72978 330010 227648 66648 22194 76308 69216 76510 231093 100042343 70892 100039535 50907 102747 193813 74410 12068 237930 317717 238328 12534 56494 67534 60409 74711 12387 89867 244071 235416 101100 216131 320244 67231 625850 66890 223723 56324 271813 110012 15239 66257 69737 226841 20844 76223 319953 59021 328572 11806 17977 238055 19017 17978 52815 18024 56322 268903 433806 15183 12914 100043869 640703 30059 11429 30056 11820 99412 12974 12530 636544 11555 66885 66948 56438 14607 100756 22226 14697 67295 19329 170711 14710 330908 14699 80883 66066 212518 14700 54644 72434 97884 14276 70527 14708 380959 14706 110826 224624 74270 14704 76630 71472 14695 69908 56447 104416 54161 83563 14693 76338 225896 66889 64337 21684 14709 74112 15874 108138 246190 216825 414084 433931 226422 14701 329777 320772 67196 109979 27392 109978 269295 14731 11889 11890 59007 54198 70325 59042 14702 12182 14232 246103 14696 69641 68468 14526 76877 58222 276846 239706 244682 56395 18700 67292 320204 11647 110417 71897 11650 18701 80294 18488 67556 17068 21683 71003 79464 68043 66913 67133 14688 56748 14756 59040 26554 71954 239827 327942 55981 98388 211255 237847 21838 235106 19335 50797 19342 19336 70349 12847 70163 67843 67164 241062 68133 13003 215494 228366 19334 235323 320840 246179 70574 19331 114654 16588 74996 12091 217371 11881 319651 76942 54160 224836 105450 228812 12575 64931 360216 107260 66111 170745 74762 54399 18793 217615 19332 328778 68311 22217 12447 68149 230801 68404 27401 227753 207965 13163 20389 74653 12448 170707 235441 26434 68947 57783 73068 268890 226418 216395 75847 72585 234663 23934 242681 109359 217057 19386 109154 53614 213827 11799 327799 52276 11844 53334 22242 19340 20842 72096 68097 69363 16319 72084 70511 217364 67511 668145 20877 56358 72373 24061 76486 76800 234700 70675 56703 445007 19376 19357 53868 57256 232973 30940 56746 243853 140703 623661 57294 78928 56455 66459 171167 71665 67099 22225 19244 320713 70316 75985 107995 108853 211253 320806 17721 17722 17716 17717 17718 17719 105083 17720 24015 67871 68366 20585 69912 76246 108089 13006 214498 225131 56273 103468 66317 668173 103737 72129 19302 235661 235497 66510 234865 22083 268281 109815 233900 320311 59015 54624 69736 17069 110379 13427 19128 13426 13424 14456 20843 19109 75452 77987 20387 12945 224792 52713 16541 17309 30937 245049 11891 66904 14148 15267 319168 64704 319167 74142 382014 319186 319178 319183 319182 193670 54197 319190 26754 319176 18034 216440 319181 20014 103963 69038 13135 13819 68646 67819 20687 116891 15248 26927 20338 235606 319169 67075 20848 625328 78303 319188 15270 80286 624153 68292 16430 382522 67895 13200 319149 72297 15077 269523 140858 12558 52615 213464 13001 13000 100039026 17869 245688 15251 12638 57320 12006 66357 21416 216185 15107 67923 19123 71586 230073 71956 228607 217069 12466 22147 19345 21454 271457 12462 19344 22151 106052 70430 66887 242960 12467 30838 12468 22143 12469 21371 12461 14466 12464 30050 108903 50762 72726 14675 53857 24012 24128 19739 22327 22152 227613 50782 22153 50754 216853 56327 50779 22142 11461 22146 14976 67199 18637 108077 67466 67951 27055 71833 14672 14447 213980 66411 73710 68628 14676 22145 22059 12465 16553 55946 50789 545486 238463 30839 14682 67134 109054 56612 20698 99371 170762 108989 231042 227699 223921 227720 269113 66679 18141 107939 69482 71805 433923 11740 54563 19069 70699 72787 18226 218210 108153 23794 30806 108154 16795 27207 210417 67097 271127 670832 229595 208936 17995 633683 77739 20044 381694 27050 269959 667279 14425 20085 269328 78330 668144 230145 20084 100689 67186 233744 382492 235130 20055 240322 75617 20357 27370 65019 11504 629957 20356 20102 17829 67834 21803 18636 269951 20103 100039649 668668 21826 667739 140474 224116 226866 672214 217734 17063 66481 59048 225058 240913 100038875 223838 100038991 99011 68028 237360 100043000 330119 67891 216725 100043295 73732 622534 66548 238217 330267 207596 16785 224697 666669 56229 100040021 353328 67025 239337 100043391 68273 17991 668182 77794 241053 94192 14194 12317 279028 432502 19989 76808 19899 100043184 19921 19934 20917 100043755 11545 12330 319195 100043209 68193 621100 19941 665189 666899 100042670 100039316 22121 18442 19106 100037258 100043876 100043893 100043423 100042986 20115 67281 76846 227197 625646 67184 100040298 68172 100042740 230075 19951 667618 100040970 66256 267019 225642 20832 56040 67437 67248 66661 100040331 217337 67941 24067 66789 27058 66384 20813 11606 72265 14061 26464 22361 107221 385643 233081 18293 78920 72345 14068 71952 66632 13495 102115 58911 63828 107817 22021 276770 271970 56316 14058 69082 14071 67902 66901 22022 69740 13494 194952 545260 269955 57295 238024 11883 77035 67014 67228 66521 105638 99349 74008 16777 77041 16779 270086 208691 226519 330817 14268 67728 116905 15007 12010 14661 213753 66855 66244 69666 76788 16912 52231 19171 107047 66537 56373 19185 19192 73902 66998 56088 67151 53380 66506 16913 228769 103554 19186 228998 19188 100041766 216150 66513 93765 22034 107045 226414 97541 239555 216443 22375 234734 107271 69606 27267 105148 23874 76784 231872 70223 76366 66143 67851 15115 18976 110960 66590 433759 22321 12977 319189 104458 85305 13722 17448 PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 96%112308 Presynaptic depolarization and calcium channel opening 12286 12287 12290 12300 12294 56808 54377 12293 12295 12296 12297 12298 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.2 Synthesis of 15-eicosatetraenoic acid derivatives 14775 625249 11688 14776 11687 19225 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.2 Signaling downstream of RAS mutants 16706 20779 12322 109880 12323 108058 12325 26413 26417 12988 109905 640703 17169 54401 26395 194231 26396 54519 29875 18176 245684 22371 16399 14268 16416 15461 110157 23980 14161 21894 215449 16653 11836 109689 216869 26403 72399 18673 16452 110135 99571 22330 NAGS VARIANTS CAUSE NAGS DEFICIENCY%REACTOME DATABASE ID RELEASE 96%9955693 NAGS variants cause NAGS deficiency 217214 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 96%5210891 Uptake and function of anthrax toxins 18550 640703 18571 26395 26396 26400 26398 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME%R-HSA-9670615.2 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations 22589 13163 SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 96%3108232 SUMO E3 ligases SUMOylate target proteins 66341 26885 17342 109113 223701 100040573 67241 20602 66647 18854 67872 67040 20230 55989 68501 19720 226026 17190 224903 21973 11545 21974 21969 13163 52615 12419 240087 56233 21849 19106 19386 21420 11799 21419 52276 15381 20842 12418 16319 57320 20877 24061 214669 445007 19357 12151 328572 19763 17246 54383 13619 17977 19017 241915 12416 17978 26370 19821 268903 15258 69912 12578 13006 12914 103468 22591 234865 30951 59015 69736 110379 13016 18035 20843 69260 216848 19697 16151 18148 22260 20181 22337 70238 19013 13436 27223 56469 13435 19365 13982 13433 22025 19883 11835 18227 14815 22059 59004 20610 208727 19016 22196 108138 100043429 110784 26423 19401 15204 229615 21834 15387 18667 170762 108989 231042 227699 223921 227720 269113 66679 22658 18141 107939 69482 71805 54563 56489 22427 19069 70699 18034 72787 18226 218210 12189 18538 12144 116870 68275 13207 106021 20687 15248 26927 212712 20878 20466 433759 22346 15182 67711 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%75108 Activation of BID and translocation to mitochondria 12122 18107 12370 14939 SERINE METABOLISM%REACTOME DATABASE ID RELEASE 96%977347 Serine metabolism 107272 56442 26943 236539 257635 231691 27364 218442 230779 574418 100678 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%163765 ChREBP activates metabolic gene expression 14104 55979 104112 107476 100705 58805 21428 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%8854691 Interleukin-20 family signaling 213208 237313 242700 16451 338374 93672 58181 116849 20849 20846 16453 20851 20848 20850 54721 16155 20847 230828 19247 16452 329244 237310 NFE2L2 REGULATING ANTI-OXIDANT DETOXIFICATION ENZYMES%REACTOME%R-HSA-9818027.3 NFE2L2 regulating anti-oxidant detoxification enzymes 328572 12914 14629 15368 12013 11911 26570 76650 17135 50493 18477 22166 18104 18024 14859 20657 71389 14630 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME%R-HSA-1912399.4 Pre-NOTCH Processing in the Endoplasmic Reticulum 18129 18131 224143 140484 18128 18132 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 96%212165 Epigenetic regulation of gene expression 15161 232440 20602 13626 319149 23989 67155 20586 20588 217031 20587 226976 208146 11450 66853 18631 15077 76719 17191 57435 66310 68801 75812 140858 21835 14311 69556 69612 68975 52615 101206 14081 19646 13486 234366 234959 101867 213464 217588 12419 54194 108946 67933 214162 665775 75565 330890 228714 28077 70208 67773 239510 21849 245688 21664 77305 171285 23808 11520 23942 56771 19014 328572 21372 231051 239985 17977 74322 19017 21374 17978 81004 66993 56310 208043 26896 15183 20185 93759 12914 20018 56406 194388 18140 14534 20016 22289 27273 237758 12568 216848 107932 14732 20249 243834 81898 11461 110052 13436 13435 13433 55982 93762 68094 22385 83796 83797 57376 244713 229542 434178 67279 108155 16475 57875 17283 67278 23945 16890 101739 16956 50724 52463 60406 17765 14055 14245 21652 74016 103968 16468 214133 103551 17979 94246 67800 100041953 71954 11770 26424 18519 19645 667501 57230 21429 59024 20019 327987 269003 21340 21339 432769 21341 64424 22130 75316 70333 233904 116848 66136 20017 11350 12491 75410 54343 11569 17192 77683 20937 431706 84505 319955 110147 56456 56200 69790 93760 170826 381022 70127 29861 269397 19708 75339 232854 67010 268996 70650 13871 12055 66420 12054 69833 77045 245841 21408 223828 14885 209357 66467 12606 20181 72198 66671 17749 100043714 17420 12572 13872 23894 14884 22196 100043429 15267 319168 233060 319167 264064 319186 319178 319183 319182 228829 319190 18432 319176 74522 319181 56637 116871 216154 116870 20467 14056 51813 319169 69792 67512 12417 20466 625328 78303 54427 67381 319188 100039610 15270 433759 622480 624153 15182 382522 IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.3 IRS-related events triggered by IGF1R 14389 74769 16367 14172 80857 18576 14170 225326 14180 14178 14177 67112 64654 14175 14174 14173 11652 14164 83379 14256 14255 19247 327826 16370 16002 16000 18176 14388 20662 15461 16001 228775 80903 18708 384783 75778 18709 75669 14186 14165 18706 81897 18607 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 96%166520 Signaling by NTRKs 21990 56437 14066 17095 12570 20393 15902 15901 23938 17172 54152 20408 15903 14283 211770 20779 16478 17936 17937 20404 11838 13656 13655 381677 107746 103967 109880 12929 26416 12928 56044 64143 18049 216148 26413 26417 29857 20416 327826 18211 109905 77480 19094 20418 102626 19730 54401 73699 26415 26395 26396 19762 110651 18176 20112 20662 19769 15461 17164 19052 19053 51792 18708 18709 18706 328572 74769 19280 21770 13712 18552 15904 18550 18553 16477 17260 17261 23939 11909 58202 13430 12064 14812 14388 21844 18212 208869 18205 107971 78405 18803 12569 12568 384783 16367 18213 11848 73086 107932 17258 11540 21406 19712 11516 19277 11517 100040260 101568 235584 67603 319520 72349 14281 13654 20807 14282 13653 19353 11771 11772 12028 71770 19247 20111 232910 11773 20848 67300 13429 12757 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.2 Negative regulation of NOTCH4 signaling 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 18132 21402 56438 11651 21335 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 22631 21762 22123 19179 19181 19182 23996 19184 26440 19166 19167 26441 26442 69077 66997 23997 RSK ACTIVATION%REACTOME DATABASE ID RELEASE 96%444257 RSK activation 20111 67071 26413 110651 26417 20112 18607 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 96%451927 Interleukin-2 family signaling 14389 74769 18707 16451 20663 16453 20851 16198 20850 16199 20963 14784 18710 19229 16186 16331 16332 16184 20416 16183 60505 15170 60504 20849 16169 16168 20846 20662 20848 16188 16185 12984 12982 16192 16191 16818 12981 18708 18709 16452 18706 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.2 Leishmania parasite growth and survival 13479 58861 246256 14131 11491 19087 19084 22612 217344 20620 14697 93671 16153 17886 26416 14710 14699 66066 14700 229709 14360 16438 16439 18747 14708 14706 14704 14695 16440 12502 14693 17096 64337 14709 14701 15162 14702 14696 19088 234779 19108 104110 20963 14678 18550 14677 14687 14679 432530 210044 104111 14688 16193 640703 70086 224129 11512 11513 11514 11515 14191 18749 14598 18803 319446 11541 23887 14129 242851 19085 ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME DATABASE ID RELEASE 96%9609736 Assembly and cell surface presentation of NMDA receptors 14811 13385 18039 14810 16559 53310 11472 13383 23859 14812 14814 108030 14813 12322 12323 22343 108058 12361 12325 319924 170483 22342 DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 96%5654696 Downstream signaling of activated FGFR2 327826 14172 80857 14180 14178 14177 67112 64654 14175 18176 14174 14388 20662 14173 14164 15461 107971 18803 80903 18708 19247 14165 18706 MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 96%9683610 Maturation of nucleoprotein 214424 328417 606496 67287 80285 52552 56637 671535 547253 22196 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME%R-HSA-5250968.4 Toxicity of botulinum toxin type A (botA) 64176 64051 20614 75209 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.3 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits 242425 14702 14696 16519 16520 54393 14697 16518 16516 14710 14699 66066 14700 14688 16521 16522 14708 16524 14706 16513 16515 14704 14695 14693 16517 64337 14709 14701 N-GLYCAN ANTENNAE ELONGATION%REACTOME DATABASE ID RELEASE 96%975577 N-Glycan antennae elongation 20451 14595 103534 56336 56386 57370 269181 53418 241230 56375 107895 20443 20440 67569 20450 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 96%1266738 Developmental Biology 21943 20437 17342 20665 20682 18992 15901 209446 17202 107508 17201 21425 22325 57257 19877 11465 19878 67224 15516 66999 12609 17395 17216 17218 65254 319713 14587 14586 20358 18550 19122 18553 19197 12517 69585 210801 14588 215798 114873 75705 20346 19262 16678 19264 216439 13684 20351 12292 15357 244058 208643 110789 17528 22288 108098 26757 19153 83433 18845 22253 17196 20349 140571 18858 22177 18846 231148 56216 22240 57764 623279 66172 13497 13508 76829 54712 20361 20907 192191 114255 18188 12933 110351 78334 214968 11876 13449 13448 68799 226251 216963 20933 13121 20788 381379 67219 13385 53310 13383 20526 19164 19165 100042305 208117 59287 100039623 76199 17918 76709 53378 73178 56443 22359 19699 13131 68089 67771 11867 56378 66713 74117 57765 17909 20230 16881 18747 12491 110651 20112 12418 15260 14013 12151 19763 54383 13619 26399 241915 12416 19821 23939 216850 12578 70834 23871 12555 12386 21413 494448 54377 17877 17878 12175 18209 12561 12608 17927 30951 17928 18007 14812 14388 21844 12300 54376 18803 11839 81905 12043 13645 67071 13388 246086 16449 19213 18508 21410 11487 21405 11925 18088 18096 15376 18012 18609 15379 378435 15377 320995 22431 53626 17258 227377 117172 56735 77055 75706 26560 435286 320864 94179 406221 69533 629873 69473 109052 70810 223917 100039486 68673 670464 435285 66708 100041488 223915 406220 16681 16675 16663 16661 268482 16682 110308 16687 110310 16691 107656 100040248 16664 239932 16665 16666 16660 16670 16694 77914 66809 71369 435273 16667 16668 105866 16680 53622 16679 406222 71888 16671 16672 53617 114566 406219 100040249 546511 76444 268905 332131 170654 74127 237934 100039757 14810 626834 17886 70625 68975 234959 21418 94112 15213 67268 70208 100043167 230594 547035 214290 13649 21802 218693 94093 15111 23942 56771 80509 104625 13395 18983 239985 57246 17292 14462 21380 15110 14461 214384 12180 14463 26896 218772 19411 103988 14534 53621 19664 72068 232791 17863 18987 216848 232232 12865 18129 107932 170787 75605 110052 19713 68094 83796 83797 57376 243743 229542 22658 67279 17283 20851 20850 70315 21349 18986 17979 13866 15375 12289 22278 18519 18222 16571 21367 53870 24046 13844 16728 12661 16825 18187 11480 13429 13193 19684 12934 16536 30942 17698 15378 110862 104099 20739 18534 20740 235281 22632 56613 74947 20266 20265 12805 20375 11733 11735 14432 640524 20742 241226 20741 319504 79221 20743 26394 20271 59024 399548 327987 20272 20274 20273 103967 11658 110876 53321 20269 72821 110880 22350 17967 269116 71653 80297 20264 213119 11350 56705 17125 17126 17127 17128 17192 17132 228140 103806 16600 69125 12295 12296 12297 12298 333639 50796 56456 19215 22762 69790 58184 93760 21762 22123 19179 19181 19182 23996 19184 18033 26440 19166 170826 50794 13190 19167 26441 22173 22178 26442 69077 66997 381022 23997 56436 17463 78893 57296 20422 26445 16334 26446 19172 19173 19175 56458 19697 13682 19177 13681 52846 26443 21388 26444 18091 19170 21423 231464 66413 667035 22190 64058 59029 67089 75613 70247 21406 20181 14106 19013 66556 208727 19016 22196 16399 26423 16402 19401 21926 264064 15978 20807 81601 54601 14783 12399 12189 20852 15185 320202 15184 216154 12631 51813 69792 56057 15205 12193 382035 20466 67381 18817 15182 12387 20602 58194 12550 23989 67155 20586 20779 20588 20587 20404 17295 18844 270118 14786 11819 223881 26416 227937 234366 26413 18787 26417 29857 20416 327826 28077 56233 19094 234594 20418 15214 54401 171285 21420 26395 21419 26396 18176 20662 20765 70166 15461 16416 13706 66203 317653 71529 21894 69511 21816 20129 668304 66344 13507 19014 16480 13506 229003 13505 386463 213498 99681 14027 12365 328572 110596 76770 19143 72432 67451 259277 16769 21372 74176 109151 19041 68668 76560 17977 11852 16939 20754 19017 13367 240633 56460 103573 17978 59035 81004 66993 17260 69632 17261 53972 15183 20185 93759 11972 108664 66290 235611 12914 54126 56406 11964 19056 11966 100039636 18018 66335 18019 11973 11974 11853 12336 56484 16476 114143 22627 12569 12568 12531 12333 18128 56438 77579 71960 20354 20130 16885 16886 22412 22410 22411 12830 18241 12829 12828 55982 12827 12826 20423 15874 12841 22417 12840 245026 12839 14048 13363 12835 12834 12833 12385 20613 57875 15227 18514 67784 16956 22416 11771 11772 71770 22408 16147 18738 232910 11773 20849 16162 218397 18749 16191 13004 12575 211586 13555 21781 12567 12443 12566 12445 14182 15529 16189 16163 58198 23967 16371 17300 14573 20472 279653 14234 57294 12159 15431 15412 16869 18504 18993 15396 67701 114249 13797 109663 15403 15904 14585 23892 231507 18510 76707 16372 20471 14733 208718 20528 620395 11481 23863 12622 18119 13590 269275 11479 18999 99377 22773 100038891 76499 13835 19109 245049 13511 70127 13510 16364 29861 269397 18772 20431 109620 19708 13512 268996 11891 171531 12055 66420 12054 69833 77836 67710 77045 245841 83671 69920 20022 20020 11603 231329 20021 69241 17749 100043714 21679 15267 21676 319168 68910 319167 13591 14281 16846 224105 18139 13654 67544 76850 230753 239528 319186 21677 319178 319183 19876 319182 259302 223666 20563 236511 14270 319190 117600 13813 20671 20997 14836 383491 27217 332221 14465 83557 319176 319181 19353 213988 217351 56637 214150 70673 22227 12683 12686 19247 94187 13819 116871 12162 51810 116870 13592 13848 13846 13845 14056 270190 13842 13840 17454 17390 13841 319169 13839 57810 13838 13837 66355 13637 13636 13643 13642 13641 20848 13640 13639 625328 13638 78303 319188 15270 18750 624153 68292 17136 23797 382522 233833 11488 21415 56839 232440 243914 246316 13626 23792 319149 213469 11496 22628 16842 17936 22612 17937 11651 11652 11450 15077 12047 21385 66310 69675 18710 19303 140858 12558 97064 13612 11886 21417 52615 232313 21752 19646 329581 213464 14360 214162 13001 13000 100039026 17869 245688 22601 17096 23808 53417 18708 18709 18479 18706 12288 74769 18707 21414 21416 231051 18481 68092 107449 107448 22772 433702 75467 194388 18140 214899 74319 11628 22289 67923 20815 11848 14159 73086 11461 70584 16412 545156 16443 22059 330662 58226 12291 13836 239556 67938 17904 17268 223435 15400 17344 232906 16475 16658 15407 67278 17880 15401 13018 15423 329559 15410 103889 18771 15436 15434 15394 15429 103968 27207 67097 670832 633683 20044 27050 667279 20085 668144 11770 20084 67186 382492 20055 75617 27370 16848 65019 629957 16410 20356 20102 14083 21803 20103 268721 668668 11352 667739 14853 17974 67300 16392 672214 20315 12757 170822 66481 54003 225058 71745 100038875 17925 100038991 18208 68028 225363 100043000 14026 67891 17690 100043295 18458 622534 13138 238217 14852 214230 16785 17973 666669 16870 100040021 16871 67025 12767 100043391 268902 668182 326622 241053 13176 18186 432502 16876 19087 19989 238276 11705 76808 20663 19899 67252 100043184 12331 19921 241656 19934 71436 18121 100043755 18643 18645 22323 16872 319195 67031 100043209 20564 68193 20562 621100 15399 19941 665189 666899 100042670 15519 100039316 22121 58234 100043876 100043893 100043423 100042986 20115 67281 54196 76846 625646 100040298 68172 100042740 19951 667618 100040970 267019 56040 67248 100040331 67941 20450 12400 20452 16190 74325 15481 192160 13430 60365 53314 68134 192170 384783 19826 14165 66441 14389 17149 14472 24136 225207 18991 18424 14180 20664 14178 14179 21389 20674 192119 14175 14173 22063 109700 22065 16398 22067 22066 22068 14581 16194 14247 22022 12224 110794 12606 17364 12986 26946 16775 16776 16777 16779 16780 226519 14268 16782 16772 23928 16773 16774 22370 328440 19119 171506 227606 384452 17701 18509 84653 56184 17293 13389 18761 21426 20583 20111 107045 18717 226414 97541 17169 216443 18505 22631 13616 22629 105148 15254 231872 13614 66143 22771 18976 17199 433759 13618 16590 15221 12977 104458 11694 21386 85305 17203 20439 13722 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME DATABASE ID RELEASE 96%190704 Oligomerization of connexins into connexons 14609 14619 14618 RHO GTPASES ACTIVATE ROCKS%REACTOME%R-HSA-5627117.5 RHO GTPases Activate ROCKs 12631 67268 67938 17904 11848 11852 11853 17880 19877 77579 71960 16885 16886 17886 19046 19878 329251 17931 18479 FORMATION OF PARAXIAL MESODERM%REACTOME DATABASE ID RELEASE 96%9793380 Formation of paraxial mesoderm 56436 13388 17463 57296 20422 26445 12387 26446 19172 19173 19175 21389 19177 18128 16842 26443 26444 270118 19170 18121 66413 59029 67089 14182 70247 103806 328572 12159 20997 333639 22416 84653 56184 17293 13389 12914 14534 13838 18519 21762 22123 16848 19179 19181 19182 23996 19664 19184 26440 19166 19167 26441 26442 69077 66997 23997 NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.6 NOTCH1 Intracellular Domain Regulates Transcription 328572 232232 20602 21372 18128 333639 79221 21402 56438 270118 81004 170787 26965 15185 667035 22190 70315 15184 15183 20185 21885 12914 15213 56233 51813 17869 14534 15214 21886 18519 15251 21888 208727 15205 15208 19664 433759 56198 264064 15182 103806 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME DATABASE ID RELEASE 96%532668 N-glycan trimming in the ER and Calnexin Calreticulin cycle 193670 227619 54197 19089 192193 12317 14827 216440 269523 12330 667035 22190 67819 19359 116891 20338 109154 74126 66967 223455 57377 66597 320011 225896 23802 22644 19179 66435 108687 75841 217364 14376 59007 HIV TRANSCRIPTION ELONGATION%REACTOME%R-HSA-167169.4 HIV Transcription Elongation 68092 433702 20922 20833 68705 98053 13871 66420 69833 67655 67710 21399 245841 107951 69920 57314 20022 114741 14885 209357 66467 20020 231329 20021 69241 66671 17749 100043714 58202 17420 67923 12572 27224 13872 27632 20924 24116 23894 12455 14884 13716 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.5 TP53 Regulates Transcription of DNA Repair Genes 17685 17350 208836 68705 98053 13871 66420 69833 67710 245841 69920 20022 14885 240087 209357 66467 20020 231329 20021 69241 66671 17749 100043714 17420 12572 22059 13872 20924 23894 14884 14281 19364 11920 20922 20833 12189 67655 21399 107951 57314 114741 12454 211651 14088 11909 58202 107986 67923 27224 27632 24116 12455 72949 69131 13716 12649 16476 69562 18861 CELLULAR HEXOSE TRANSPORT%REACTOME DATABASE ID RELEASE 96%189200 Cellular hexose transport 56636 246787 20528 227659 19729 212980 56017 20525 117591 64452 109342 20537 20526 353169 435818 170441 230612 20527 72045 DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 96%5688849 Defective CSF2RB causes SMDP5 12984 12982 20387 20390 20389 20388 FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.4 Formation of the ternary complex, and subsequently, the 43S complex 16785 57294 27979 56347 13669 53356 68135 55944 66085 73830 16341 223691 667035 54709 100042807 98221 66235 27207 67097 670832 100039316 633683 20044 27050 667279 20085 668144 20084 382492 20055 75617 20115 27370 629957 76846 20102 100040298 20103 668668 667739 13665 66481 67204 225058 100038875 267019 26905 67941 TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME DATABASE ID RELEASE 96%168927 TICAM1, RIP1-mediated IKK complex recruitment 56532 11796 106759 12675 16150 16151 66105 667035 100041766 216080 22190 93765 66589 22034 142980 19766 11797 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 96%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 56436 17463 57296 20422 26445 26446 19172 19173 19175 19177 56438 26443 26444 19170 66413 66105 667035 22190 59029 67089 70247 15251 53417 16475 100041766 13819 101543 112407 112406 29806 67923 21762 22123 19179 19181 19182 23996 19184 26440 19166 216080 19167 22346 71745 26441 26442 69077 66997 23997 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 96%139915 Activation of PUMA and translocation to mitochondria 22062 209456 21981 211586 13555 22059 21781 22061 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 96%9025094 Biosynthesis of DPAn-3 SPMs 11684 11687 19225 11689 DASATINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 96%9669914 Dasatinib-resistant KIT mutants 16590 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 96%9620244 Long-term potentiation 640703 14799 14811 13385 18039 14810 53310 11472 13383 20779 23859 14812 14814 64011 14813 211323 12322 12323 108058 12325 14800 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME DATABASE ID RELEASE 96%5579029 Metabolic disorders of biological oxidation enzymes 394433 320997 13115 17161 110115 13081 242585 13072 13074 21391 232174 13079 546726 71519 13078 13075 244209 13070 14262 14629 22017 13123 104086 68165 14149 11720 109652 14148 14598 269378 14854 75475 14630 394436 MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.5 Miscellaneous substrates 74134 320997 13120 71519 545817 106648 631304 622127 100040843 13118 72054 56448 ASP-3026-RESISTANT ALK MUTANTS%REACTOME DATABASE ID RELEASE 96%9717264 ASP-3026-resistant ALK mutants 11682 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME%R-HSA-8853334.5 Signaling by FGFR3 fusions in cancer 14184 MET INTERACTS WITH TNS PROTEINS%REACTOME DATABASE ID RELEASE 96%8875513 MET interacts with TNS proteins 16412 319939 217169 15234 17295 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME DATABASE ID RELEASE 96%451326 Activation of kainate receptors upon glutamate binding 18796 18797 14702 18795 14696 14697 14710 14699 66066 14700 14688 14708 14706 110637 640703 14704 14807 14806 14695 13385 14805 52589 53310 14693 13383 14809 64337 14709 14701 FLT3 SIGNALING%REACTOME DATABASE ID RELEASE 96%9607240 FLT3 Signaling 14389 16923 20491 12402 14783 11651 11652 20851 20850 20963 14256 667035 22190 19271 12576 14255 19247 14360 12988 54607 18176 20662 15461 56484 11352 17444 216233 15162 16818 18708 12125 77799 23797 18706 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 96%111996 Ca-dependent events 12326 19088 55984 19108 19087 19084 104110 12322 12323 108058 12325 432530 210044 26413 104111 18747 100039592 640703 224129 18753 11512 18783 11513 110355 11514 18575 11515 18574 18573 18749 207565 18752 18750 19085 IP6 AND IP7 TRANSPORT BETWEEN CYTOSOL AND NUCLEUS%REACTOME DATABASE ID RELEASE 96%1855229 IP6 and IP7 transport between cytosol and nucleus 18141 107939 69482 71805 54563 19069 70699 72787 18226 218210 69912 103468 19386 234865 59015 69736 110379 170762 108989 231042 227699 223921 227720 445007 269113 66679 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME DATABASE ID RELEASE 96%69183 Processive synthesis on the lagging strand 68275 18969 18968 18971 327762 68240 18972 14156 19075 19076 19891 67967 16881 69745 18538 MRNA SPLICING%REACTOME DATABASE ID RELEASE 96%72172 mRNA Splicing 66053 66983 15381 19655 70616 68598 67959 20462 107701 67480 72047 68092 74326 67500 433702 75956 56031 80744 66101 70225 68879 320632 67418 212880 66585 22380 74351 54723 83486 19134 545085 66877 244672 238831 23983 24010 18521 20227 83701 74255 57905 67229 68479 70312 330361 66177 67797 67050 209416 76167 76522 22184 72654 20222 50996 28035 78372 72886 67225 18949 60321 67178 66492 71715 215051 66618 230596 70052 70767 67922 66070 66381 77644 66810 108160 319322 100034361 66801 237859 19205 68592 27967 68035 217207 76936 67471 69757 68988 208768 71702 76793 22668 68981 67684 20639 209003 229279 227707 101943 81898 67439 94315 20646 192159 53317 15382 53379 56258 59013 98758 11991 11834 15388 15387 66055 68816 50783 67197 67678 54633 66094 67465 69192 78651 27756 67285 66373 236732 67958 68183 76479 20624 66642 75062 27366 228005 28000 13204 100041953 76938 13207 233908 66125 64340 622469 225027 15481 67996 22608 51796 192160 71713 53817 233073 20382 110809 60365 20383 21681 68134 108014 192170 69207 19826 193116 66441 17149 100040029 107686 384091 666609 100040177 67010 68705 20641 98053 20638 66420 69833 67710 245841 69920 67332 20022 20020 231329 20021 72198 69241 17749 100043714 170791 20630 14105 20637 53607 56070 67039 72459 56194 100336 72935 13211 56215 51810 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.5 GAB1 signalosome 13649 21802 20779 12223 14388 71920 94212 13874 15200 19303 11839 13645 18708 19247 12988 18706 NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME DATABASE ID RELEASE 96%9603505 NTRK3 as a dependence receptor 18213 12028 58202 DEVELOPMENTAL LINEAGE OF MAMMARY GLAND MYOEPITHELIAL CELLS%REACTOME%R-HSA-9927432.2 Developmental Lineage of Mammary Gland Myoepithelial Cells 11839 21802 13645 G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME%R-HSA-418217.5 G beta:gamma signalling through PLC beta 18796 18797 14708 14706 14702 18795 14704 14696 14695 14693 64337 14709 14697 14701 14710 14699 66066 14700 14688 FXIIA ACTIVATES PLASMA KALLIKREIN-KININ SYSTEM%REACTOME DATABASE ID RELEASE 96%9970672 FXIIa activates plasma kallikrein-kinin system 319178 319183 319182 319190 319149 319176 18793 319181 15077 232345 51788 72461 16678 385643 94175 319169 12261 625328 15267 78303 319188 58992 319168 15270 16621 319167 12258 624153 319186 382522 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME DATABASE ID RELEASE 96%3065676 SUMO is conjugated to E1 (UBA2:SAE1) 100043429 56459 50995 20610 IRAK4 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5603041.4 IRAK4 deficiency (TLR2 4) 17087 117149 12491 21899 20193 12475 17874 14161 12229 434174 21898 24088 21897 20201 110135 20202 99571 266632 SIGNALING BY MAP2K MUTANTS%REACTOME%R-HSA-9652169.2 Signaling by MAP2K mutants 26395 26396 26413 26417 DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 96%5688890 Defective CSF2RA causes SMDP4 12984 12982 20387 20390 20389 20388 PARASITE INFECTION%REACTOME%R-HSA-9664407.3 Parasite infection 17913 246256 17973 17909 105855 242687 330319 76884 22612 11308 22324 17886 108100 12928 11461 101314 26413 26417 14360 22325 11350 12502 57257 140579 17096 330662 11465 15162 140580 20430 17918 76709 19353 73178 20963 12229 56443 80987 68089 67771 11867 56378 66713 74117 245880 14191 14083 22376 215280 68524 50884 17925 83767 17882 329165 CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.3 CRMPs in Sema3A signaling 26757 14159 18845 18186 65254 18844 18846 22240 56637 243743 12934 12569 12568 20346 12933 14360 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME%R-HSA-159854.5 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 18550 56316 19128 14058 14071 19123 14068 66901 14456 14061 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME DATABASE ID RELEASE 96%3595172 Defective CHST3 causes SEDCJD 12111 29873 121021 13003 13004 53374 12032 13179 SIGNALING BY ALK FUSIONS AND ACTIVATED POINT MUTANTS%REACTOME DATABASE ID RELEASE 96%9725370 Signaling by ALK fusions and activated point mutants 16367 12575 78798 268980 13666 108147 215114 19645 12211 19043 21402 56438 19084 14025 16364 11682 12047 70297 16153 18148 17886 26965 667035 22190 26413 26417 327826 16573 13433 19386 22059 238037 14939 67533 14268 16154 14235 22160 18646 108989 54167 232679 18708 18709 81910 76850 239528 18706 22330 74769 672511 236511 17246 13191 26420 20850 54721 59069 18412 14784 16477 217351 214150 16593 17210 69162 15170 380928 17454 26419 116849 12608 27267 20846 20848 16476 667739 107971 67300 433759 18803 21787 17698 22637 67160 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 96%9665247 Resistance of ERBB2 KD mutants to osimertinib 13866 59079 12539 15519 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 96%168142 Toll Like Receptor 10 (TLR10) Cascade 12234 19697 21402 73086 16150 16151 192656 17874 16179 26965 71481 667035 26416 211550 22190 17258 20203 26410 26409 20210 24110 26413 103583 257632 26417 26940 266632 26401 80750 223664 53791 107607 19094 69721 102626 231130 93834 270151 73699 11596 26395 67454 22059 240518 71966 110651 108960 20112 59025 100040260 101568 17164 235584 19052 67603 319520 19053 72349 51792 14281 12370 21770 22030 67245 26399 26400 18034 26398 26420 13712 26414 26397 17260 434174 66513 93765 66589 23939 22034 66724 68652 20111 11909 26419 12675 16476 18033 18035 18036 11820 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 96%5610780 Degradation of GLI1 by the proteasome 12234 56436 17463 57296 14632 20422 26445 26446 19172 19173 19175 19177 21402 56438 26443 26444 19170 66413 26965 667035 22190 59029 67089 70247 18747 21762 22123 18222 19179 18749 19181 19182 23996 19184 26440 19166 24069 19167 26441 16396 26442 69077 66997 23997 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME DATABASE ID RELEASE 96%975576 N-glycan antennae elongation in the medial trans-Golgi 20451 53618 98388 14595 71665 103534 17309 56336 56386 16866 57370 53418 269181 56375 217664 241230 107895 12640 20443 68947 17158 20440 67569 20450 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME%R-HSA-159231.4 Transport of Mature mRNA Derived from an Intronless Transcript 18141 107939 69482 71805 54563 19069 68092 70699 72787 433702 18226 218210 69912 13684 103468 19386 234865 54451 59015 69736 51786 94230 74320 21681 68188 54188 110379 66899 170762 108989 53319 231042 227699 223921 227720 445007 269113 66679 SIGNALING BY WNT%REACTOME%R-HSA-195721.7 Signaling by WNT 233833 18796 18797 14686 21415 20682 18795 232440 14681 12387 319149 20586 16842 11651 12389 11652 15077 66310 140858 12005 21752 213464 93840 20668 234130 13001 73016 13000 84035 100039026 228770 17869 103236 56811 20680 24117 14296 74499 207742 14160 20319 23808 20377 20187 20675 20677 212398 100683 107515 192199 68151 77578 68911 12006 67772 216869 56433 67087 30930 80288 16974 65114 13380 16973 329252 73739 72135 328572 73130 20679 68339 106042 239405 407821 21414 21416 103573 208846 72780 19354 12914 14797 640703 19055 19056 18018 19058 13017 13016 11789 170758 27373 93687 11848 56513 56438 57265 14697 22412 216795 14710 14699 66066 14700 22410 22414 22411 14708 14706 22409 14704 14695 21886 14693 21888 64337 14709 22417 14701 54198 14702 93735 14696 14367 14365 17283 14362 22415 11798 14366 22413 22416 22420 11771 22418 11772 14370 71770 22422 22421 14368 22423 14369 20890 14688 22408 21887 26554 18719 232910 11773 13542 13544 13543 67300 12757 360216 84092 68031 21951 74493 12322 18643 16438 16439 75410 53627 16440 73699 19052 105782 19053 66313 51792 226849 225849 26931 21770 26932 319152 56505 74325 214498 235497 21762 22123 19179 19181 19182 23996 19184 75788 18752 26440 19166 19167 26441 240756 26442 94253 69077 66997 23997 12234 56436 17463 57296 20422 26445 26446 19172 19173 19175 72345 19177 20674 21402 26443 26444 19170 66413 26965 667035 22190 18751 59029 26409 67089 70247 21885 15267 319168 319167 76850 239528 319186 319178 319183 319182 81601 236511 319190 20671 12399 319176 319181 19353 213988 217351 56637 214150 17454 319169 22631 625328 78303 319188 15270 433759 26563 26564 22419 225600 18750 624153 19091 19092 18587 18588 382522 18099 Statin pathway%WikiPathways_20260410%WP1%Mus musculus Statin pathway 16971 11814 11813 15450 11808 13350 16956 20778 18830 16835 11303 13122 15357 11806 20652 16816 17777 11812 11816 IL 9 signaling pathway%WikiPathways_20260410%WP10%Mus musculus IL 9 signaling pathway 20851 384783 12702 20848 26395 16451 16186 54721 26417 11651 20846 16367 18708 81601 16199 19247 16198 20850 14784 269523 26396 20416 16453 26413 Cholesterol biosynthesis%WikiPathways_20260410%WP103%Mus musculus Cholesterol biosynthesis 18194 110196 208715 66234 20775 319554 192156 13121 15357 13360 68603 235293 14137 16987 17855 Selenium metabolism selenoproteins%WikiPathways_20260410%WP108%Mus musculus Selenium metabolism selenoproteins 109815 107585 107869 223776 232223 214580 20342 80795 27361 13370 20687 19946 65967 14778 625249 50880 26462 69227 75420 71787 18986 20768 71984 75512 19697 14080 14281 28042 20363 13371 72657 20226 50493 20683 211006 109079 12916 14775 114679 20341 20364 280621 18024 14776 16476 18033 74777 TGF beta signaling pathway%WikiPathways_20260410%WP113%Mus musculus TGF beta signaling pathway 21814 24136 21803 55994 16451 26420 17125 12393 21815 20481 17128 12159 21926 14313 14225 20750 22408 21813 21825 16878 18121 16842 13805 17130 20482 94187 26417 12399 21812 18033 17127 68010 328572 18787 16323 268977 17126 20848 230597 15978 16476 17131 14106 15461 12387 14281 209446 13645 20846 12914 17129 16420 Hedgehog signaling pathway%WikiPathways_20260410%WP116%Mus musculus Hedgehog signaling pathway 14632 24069 13548 16147 14451 268697 19207 13363 12914 12534 14634 15245 19206 20423 16002 20481 19335 269209 319757 20220 14633 20466 Glucuronidation%WikiPathways_20260410%WP1241%Mus musculus Glucuronidation 216558 109785 226041 66681 15275 22235 72157 394433 613123 72094 71773 100727 394430 94215 394436 552899 22236 Non homologous end joining%WikiPathways_20260410%WP1242%Mus musculus Non homologous end joining 22596 14375 19090 17535 108138 75570 19360 75570 EBV LMP1 signaling%WikiPathways_20260410%WP1243%Mus musculus EBV LMP1 signaling 26406 18034 26419 21926 19697 67399 71609 15977 16150 22034 12675 26409 18033 16179 22029 20304 53859 12675 16151 20297 26413 15519 Estrogen signaling%WikiPathways_20260410%WP1244%Mus musculus Estrogen signaling 15182 26420 13871 24074 99730 20466 26413 17420 12443 229906 12043 69920 15183 13872 13982 12912 18706 328572 16150 20185 245841 231329 18747 20021 66464 12572 16476 14683 56233 12189 11651 74197 15185 102216272 108143 66420 14885 14884 14688 235459 68153 20779 15461 68705 16151 20022 20662 109880 26395 26416 18033 13712 216148 433759 21343 21374 17749 12914 76854 14281 69833 14784 16202 23894 226182 14699 67710 15184 70315 208727 209357 20020 66671 20683 12675 Transcriptional activation by Nfe2l2 in response to phytochemicals%WikiPathways_20260410%WP1245%Mus musculus Transcriptional activation by Nfe2l2 in response to phytochemicals 18750 26419 231872 12608 18024 50868 14629 15368 17132 13844 18706 14858 18104 14630 Methylation%WikiPathways_20260410%WP1247%Mus musculus Methylation 11720 232087 22017 18948 108645 140483 21743 18113 12846 Oxidative phosphorylation%WikiPathways_20260410%WP1248%Mus musculus Oxidative phosphorylation 75406 66043 228033 17992 595136 66218 227197 66091 11951 66916 68198 17705 407785 66377 78330 67264 68375 68202 230075 67273 66108 28080 66416 11950 68197 27425 17705 17706 17993 17720 407790 67942 68342 14939 71679 68349 72900 17721 17718 17991 226646 225887 54411 66046 67126 11958 11947 17716 68055 11957 70495 57423 67130 17722 69875 11946 17995 17719 17717 EPO receptor signaling%WikiPathways_20260410%WP1249%Mus musculus EPO receptor signaling 13857 16452 20779 30955 14784 13856 20416 228026 20846 26417 26395 26396 11651 26413 12703 20851 12700 20850 20848 19264 19273 110157 20662 384783 16367 218397 Arachidonate epoxygenase epoxide hydrolase%WikiPathways_20260410%WP1250%Mus musculus Arachidonate epoxygenase epoxide hydrolase 13850 12858 12868 13850 Metapathway biotransformation%WikiPathways_20260410%WP1251%Mus musculus Metapathway biotransformation 13120 64580 14860 110198 70646 69083 394433 17961 394433 56050 104086 17423 71519 14263 83398 50785 14872 72054 81906 15476 211666 15478 320997 14775 60322 22017 107146 140483 12012 14262 76969 14857 13081 53374 394430 56362 394434 13116 102294 56441 14865 14776 110115 394436 13077 11677 195646 269854 14778 13078 14873 77951 74134 20860 13075 13079 546726 20859 50786 13115 232174 14871 58810 14261 67877 552899 21743 18113 68312 545817 98956 58250 71367 330217 13122 14874 54371 13107 53897 319415 76263 545276 23908 13124 13076 14782 29859 50787 13072 14866 552899 15531 16497 67553 71797 13123 13070 72094 98388 69083 13849 66176 269642 20887 72117 628779 625249 244209 54710 54200 545963 14854 14780 13850 56773 14862 16499 55990 14859 16498 70999 226564 13082 13106 72136 73671 328779 13074 26887 56615 67861 68396 94284 14858 14870 12846 22236 66447 208665 68214 14866 381334 68947 13121 59031 Amino acid conjugation of benzoic acid%WikiPathways_20260410%WP1252%Mus musculus Amino acid conjugation of benzoic acid 107146 60525 Type II interferon signaling IFNG %WikiPathways_20260410%WP1253%Mus musculus Type II interferon signaling IFNG 20847 15978 20846 20375 16391 15900 16452 16451 17329 12703 13058 19247 15894 16363 15980 14468 21354 15979 97122 15977 16176 19106 100038882 18126 16362 15945 16912 12702 18753 16364 15958 12265 19692 Apoptosis%WikiPathways_20260410%WP1254%Mus musculus Apoptosis 58801 12371 17246 12018 22031 16362 18033 14102 11797 66593 11651 14940 94185 12015 18035 12362 19766 16363 18036 16992 12363 54139 12367 18646 21937 16001 19697 12675 12028 11783 21938 11796 12122 85030 26414 22029 16150 27056 13347 54131 12366 12123 22062 72193 12369 17869 21926 16002 12905 16151 51800 22030 12633 12050 18708 71609 11799 16000 21933 16476 12177 13368 12043 54123 12048 16364 18037 22059 26398 12370 11798 14103 22035 15201 14082 17210 12368 12125 26401 22061 Nod like receptor NLR signaling pathway%WikiPathways_20260410%WP1256%Mus musculus Nod like receptor NLR signaling pathway 59079 12675 16151 19697 26419 13844 26409 16150 21939 Mismatch repair%WikiPathways_20260410%WP1257%Mus musculus Mismatch repair 16881 18971 17685 19687 17688 17350 26909 18538 68275 Homologous recombination%WikiPathways_20260410%WP1258%Mus musculus Homologous recombination 67967 19361 12190 68275 27354 19365 69745 11920 623474 17535 18971 68275 18972 19360 Retinol metabolism%WikiPathways_20260410%WP1259%Mus musculus Retinol metabolism 63857 63954 11668 320092 19401 19378 67470 77974 19682 20148 232174 237636 56847 27409 16956 13106 19892 170752 20778 54200 545963 79235 20182 98711 67442 19659 20181 26876 20887 13082 12491 19411 235033 11522 20183 12904 12903 19771 19660 19662 218772 ErbB signaling pathway%WikiPathways_20260410%WP1261%Mus musculus ErbB signaling pathway 216148 56637 83961 320207 13869 23797 18803 12223 26419 13867 211323 13649 13866 11836 12015 11839 14388 13712 21802 20662 20779 14784 18183 13874 17869 20850 12575 26395 16476 15200 13645 13685 12928 18750 12576 12322 56717 15461 80794 70584 17973 26400 26413 14083 11350 100042150 Aflatoxin B1 metabolism%WikiPathways_20260410%WP1262%Mus musculus Aflatoxin B1 metabolism 110198 13077 14871 14862 13849 Mitochondrial gene expression%WikiPathways_20260410%WP1263%Mus musculus Mitochondrial gene expression 21780 15161 224481 15278 226169 66410 545725 14390 216151 26379 18181 213054 20683 19017 170826 17876 12326 12912 19055 Estrogen metabolism%WikiPathways_20260410%WP1264%Mus musculus Estrogen metabolism 12846 94284 13077 394436 20860 20887 18104 13076 394434 14857 22236 14862 13078 Polyol pathway%WikiPathways_20260410%WP1265%Mus musculus Polyol pathway 16548 230163 11677 20322 SIDS susceptibility pathways%WikiPathways_20260410%WP1266%Mus musculus SIDS susceptibility pathways 20271 11516 16153 21990 17161 20683 15205 12268 19712 15550 212139 13018 18095 20191 108015 21926 328572 625018 14461 16511 13195 12391 11998 11517 19017 170826 16917 11438 18044 16535 17172 19883 54006 15558 22355 13798 16193 22608 14462 22354 216343 15567 217946 15510 18992 260298 230857 14695 11835 14235 16194 12912 16535 14815 11859 19713 15208 27140 18033 18088 18935 11444 Fatty acid beta oxidation%WikiPathways_20260410%WP1269%Mus musculus Fatty acid beta oxidation 97212 11364 231086 66853 12896 11409 13177 93747 270076 15107 231086 11370 14571 433256 13382 60525 21991 14626 14081 67460 15450 57279 11363 12908 16890 216739 12894 12895 50790 14933 67717 12651 110446 74205 16956 Endochondral ossification%WikiPathways_20260410%WP1270%Mus musculus Endochondral ossification 11647 20750 14184 17386 11595 12166 16147 14182 16002 12161 16000 67760 21803 12283 17260 12824 23794 12399 19226 14172 12313 20259 12393 14173 20679 19206 18605 18747 16568 58250 13039 21808 11651 14634 208715 22339 17395 12406 12162 12577 20682 21833 20846 11504 14600 18792 17313 20851 12813 240913 16001 21821 18214 12020 58214 20378 18791 208727 19227 19228 20678 21859 Selenium micronutrient network%WikiPathways_20260410%WP1272%Mus musculus Selenium micronutrient network 14775 19215 11689 17708 14782 103711 19223 64292 21391 17769 98256 14776 56473 20363 75512 80795 22436 238505 76267 17709 12359 14778 625249 Folic acid network%WikiPathways_20260410%WP1273%Mus musculus Folic acid network 64292 19223 75512 56473 12411 26462 12359 17769 98256 14776 19215 80795 20364 14778 238505 11689 27361 14782 22436 50493 103711 14775 625249 Oxidation by cytochrome P450%WikiPathways_20260410%WP1274%Mus musculus Oxidation by cytochrome P450 13082 66427 72017 320997 109672 13078 266690 123956256 320635 110115 13115 72054 546726 13121 13123 13075 13079 232174 13122 545817 13124 74134 56050 244209 13116 13120 13077 102294 71519 81906 13106 13070 77951 18984 13074 104086 13107 109754 13072 13081 13076 GPCRs non odorant %WikiPathways_20260410%WP1396%Mus musculus GPCRs non odorant 14829 56696 99633 108068 18387 17201 12769 19218 208188 12777 12614 54393 18168 15558 20132 70839 54140 13051 11551 58861 15566 18441 67168 19228 319430 13349 225192 387349 14293 11555 14427 15465 17202 107934 14766 22354 20607 14365 57385 16867 19216 14367 12771 12000 114229 217369 13489 242093 15562 12672 57252 18430 213527 69296 11542 18442 140741 12311 99633 242425 20605 93746 13490 57253 387285 20608 18216 230777 12671 19214 22045 111174 14816 107221 94226 244701 319757 12669 14309 230775 110168 107831 18167 210198 12922 18101 69412 78826 14744 54598 13492 14652 246313 13610 11554 57265 11517 15557 387616 211578 11552 11607 99296 108073 11539 14602 15564 19220 381853 14370 387344 387355 210933 12773 319239 13491 18386 574402 53883 11608 13617 140795 320463 12273 65086 14368 216749 14062 229214 11609 59289 667992 53978 11549 233571 213439 21338 381489 238377 11541 15565 12801 140498 70086 170757 11540 12770 12061 14739 15560 233079 233080 233081 18217 12921 387353 17200 15563 26364 93896 12425 14428 232431 330814 12458 104443 57260 54199 13611 22355 14823 12776 14369 12802 227288 239283 387515 84112 22095 14371 71223 14064 14767 213788 13618 23796 17171 108069 14063 381810 12426 12765 12767 11550 11556 12775 12766 57811 387347 574417 226304 12768 20609 19222 52614 21336 237175 14715 23832 13733 80901 319229 12267 11553 18390 319387 236781 14745 19065 268934 14065 12145 13603 80885 243764 74191 353167 17773 26361 227289 19204 16995 15551 239336 12374 20606 64297 14366 12778 15550 13609 18169 17203 30044 13488 78134 15559 353344 14765 12772 108071 76854 57254 12062 226278 19217 21390 207911 108072 11548 21337 18166 58182 19219 15552 15466 17199 18241 14362 14527 GPCRs odorant%WikiPathways_20260410%WP1397%Mus musculus GPCRs odorant 258927 381413 233221 233919 83770 18389 14747 238725 259005 12209 259013 229323 493809 240888 80706 67549 14608 404239 14762 258697 258734 387345 68151 218066 18312 353166 319197 229357 338346 212541 258725 78249 215855 383563 215798 237716 54672 18328 224792 18307 387342 107173 18316 52710 227326 58245 14160 209513 14763 258585 404242 76206 14788 18322 110326 258478 406186 243979 233230 113850 381628 258769 215854 12057 22296 113845 258770 80910 18315 113848 27216 113846 209512 276742 78308 171469 241263 387354 258565 64095 64378 236798 259017 436440 24100 233231 241070 100129 381974 73010 258319 70693 78560 321019 277463 113851 258318 259012 258728 353346 503558 238252 70771 257898 112408 22297 229714 77596 245424 113847 387346 113856 329252 71862 83771 353148 269053 233670 269604 228228 404240 258573 387514 80978 387340 57272 113853 258362 319200 14748 435529 353165 81006 387348 235854 387512 387343 23890 83924 258327 258939 14761 18373 235256 113849 258566 70713 14539 14764 56861 84111 14760 80290 387511 258498 387351 56544 382045 11536 64450 68526 244238 257890 258869 404238 243270 258742 258310 381886 243277 211577 258581 217302 239853 239845 217143 258923 387341 258738 209776 387513 387339 107515 14738 18310 239530 387352 GPCRs orphan%WikiPathways_20260410%WP1398%Mus musculus GPCRs orphan 277463 78308 67549 107173 236798 319197 76206 68151 70713 58245 68526 52710 240888 83924 435529 224792 436440 217143 24100 Oxidative damage response%WikiPathways_20260410%WP1496%Mus musculus Oxidative damage response 18538 12262 12577 12260 12273 21938 15139 22031 12043 12902 12015 11783 338372 26415 12540 22030 12268 12575 13067 50908 50909 56196 13063 51789 12267 26398 67384 12263 12576 22029 18037 18033 21926 13197 26401 26414 22034 12259 12367 12018 12371 Dopaminergic neurogenesis%WikiPathways_20260410%WP1498%Mus musculus Dopaminergic neurogenesis 18012 18424 12577 13799 16917 22408 14633 11924 17701 13195 20848 11668 320092 13162 13798 18088 18227 21823 17172 19713 18742 214084 14179 18096 14472 15376 110648 14632 20423 20674 21803 IL 5 signaling pathway%WikiPathways_20260410%WP151%Mus musculus IL 5 signaling pathway 11909 20851 12028 16414 56637 16409 12929 56484 18708 15162 23921 18709 12983 216148 12576 19229 12445 16185 16192 20963 11689 18033 20416 18751 20677 13430 26396 16451 26413 14784 18035 15894 18783 12703 16476 20850 22248 16653 22631 18753 13712 12983 15461 16191 12402 30955 26417 20848 20111 107746 16452 12387 11651 15163 110157 19247 606496 11690 12229 110351 26416 15170 20846 22324 26420 18712 53378 17096 19353 Regulation of cardiac hypertrophy by miR 208%WikiPathways_20260410%WP1526%Mus musculus Regulation of cardiac hypertrophy by miR 208 14463 140781 74318 327987 14613 17700 MicroRNAs in cardiomyocyte hypertrophy%WikiPathways_20260410%WP1560%Mus musculus MicroRNAs in cardiomyocyte hypertrophy 22416 20848 26417 16878 16973 213435 54720 18751 19353 208727 79221 18607 16000 26419 26413 12675 12572 12387 16151 11606 13542 73181 56637 23939 18706 13019 26396 18708 18709 26398 18033 16001 53859 56233 12700 19877 107951 19091 18707 18796 56489 26416 14183 107589 110157 13614 16150 16195 57265 16974 26400 74769 18710 211323 13645 17876 19056 11652 21803 56717 14173 26397 225724 23938 230899 18780 30955 21926 19878 26395 18158 15184 11848 22418 14463 224045 11651 19055 108058 66513 26399 14362 12313 Glycolysis and gluconeogenesis%WikiPathways_20260410%WP157%Mus musculus Glycolysis and gluconeogenesis 235339 13808 20528 21991 20526 13806 56485 106557 18655 14751 103988 13382 18598 14719 14120 20527 13807 14377 56012 18563 18534 16832 212032 16833 68263 27402 14433 18746 55951 18642 14447 18597 18770 11674 18663 17448 56421 20525 14718 15275 11676 230163 18648 15277 14121 18641 17449 16828 70456 Iron homeostasis%WikiPathways_20260410%WP1596%Mus musculus Iron homeostasis 22041 14319 50765 14325 66438 64602 84506 21926 16193 69585 15216 16194 53945 16175 Cytoplasmic ribosomal proteins%WikiPathways_20260410%WP163%Mus musculus Cytoplasmic ribosomal proteins 20084 27367 20005 19896 11837 56040 22121 26451 19989 19988 27176 110954 270106 19921 19933 19934 19943 19944 19951 57808 54217 27050 16898 20103 20055 20091 20042 27370 26961 19941 19946 19981 67945 19982 20102 20104 20115 20116 100040298 27207 20054 54127 20090 14109 67186 269261 66480 319195 67025 19899 76808 108168140 268449 68193 19942 114641 68436 619547 66489 100502825 67281 67671 67891 67248 67097 68052 20044 16785 267019 20068 20088 20085 67427 66481 66475 75617 57294 78294 20111 20112 110651 58988 Glutathione metabolism%WikiPathways_20260410%WP164%Mus musculus Glutathione metabolism 23887 14598 14775 14782 16790 110175 14857 68312 14776 14854 14629 15926 14598 14630 14778 14872 75475 14871 625249 14381 14863 13479 68044 Apoptosis modulation by HSP70%WikiPathways_20260410%WP166%Mus musculus Apoptosis modulation by HSP70 21937 12371 12370 12366 14082 26401 19766 14102 12367 18033 193740 12368 11783 26414 12122 12369 26926 Acetylcholine synthesis%WikiPathways_20260410%WP175%Mus musculus Acetylcholine synthesis 13026 18598 11423 18597 18618 12660 12647 Mechanisms associated with pluripotency%WikiPathways_20260410%WP1763%Mus musculus Mechanisms associated with pluripotency 13990 12914 19696 13016 21752 12578 17246 12575 20841 11819 13865 20683 213742 17480 14175 81879 18109 12168 17128 18128 20130 22418 17344 19164 22018 13380 12622 18033 13590 19280 50764 13445 17191 17192 75560 108155 22196 59024 15182 21849 22632 56380 19821 26424 21414 104383 65969 22592 13197 328572 51869 226442 66830 11614 22764 17865 16600 13211 19712 59016 15161 18999 26417 21432 21386 15901 14465 18986 18451 14388 16451 216233 16195 16880 16878 11789 12005 16842 22773 94093 56717 11651 17869 12591 12443 20848 99377 15221 71950 20674 13194 22059 353283 19211 18707 26395 110157 15461 17126 21812 18119 51810 14182 12159 11477 17125 12550 12387 21415 16412 56637 13542 208727 269424 14362 16973 22416 19247 14784 22702 328572 22286 26380 13619 22772 104156 21420 18424 69890 56353 628746 21888 19664 58198 14281 54624 209446 81601 20662 16324 21803 17131 14030 20588 11545 13018 22097 17342 76804 104263 22715 16647 12367 65079 12505 26413 18103 21425 110147 54427 16367 16337 16333 20423 319757 77683 102060 17977 13017 18747 13435 13436 21418 20230 212712 77766 20750 59004 66894 12912 18140 26611 74178 14176 13164 231413 14797 18712 223775 18260 11909 15894 12189 22218 52463 20997 21331 14472 13864 22025 22668 252870 104248 23988 19877 19878 18752 103551 16009 57278 76509 64058 13139 15260 63913 15162 269275 93762 20833 20689 107932 15078 22589 93960 51792 18291 14566 11479 17765 19646 245688 52615 16468 18158 18160 69719 13347 14056 17127 14055 13626 233726 16211 57258 226432 20687 21750 15111 12934 20591 216850 381022 22289 17260 17261 17927 75788 20393 83814 15251 73693 16598 15201 13433 22083 235497 214498 66317 74766 19651 12566 19698 76893 17975 17089 21848 22160 332221 67155 18854 99982 234366 19697 20586 229542 66923 433759 116870 20466 12224 23942 76007 21886 One carbon metabolism and related pathways%WikiPathways_20260410%WP1770%Mus musculus One carbon metabolism and related pathways 214253 14780 20655 246277 212862 13361 13026 232087 14782 236899 75320 99712 20657 11720 67305 107869 14854 218865 13435 64918 17769 13429 18805 20656 75512 12651 14415 12583 14417 14711 12116 20425 68671 192166 625249 14776 14775 238505 14630 14778 229709 12411 74129 12012 108037 12660 22171 14629 18618 12035 14629 12036 14630 268782 14854 Kennedy pathway%WikiPathways_20260410%WP1771%Mus musculus Kennedy pathway 320951 99712 18618 12651 20397 19210 12660 236899 68671 75320 13026 214253 212862 27388 Heme biosynthesis%WikiPathways_20260410%WP18%Mus musculus Heme biosynthesis 11656 14151 19044 12892 15288 11655 17025 22276 22275 GPCRs class A rhodopsin like%WikiPathways_20260410%WP189%Mus musculus GPCRs class A rhodopsin like 258416 258501 20606 54140 12062 258605 11554 93690 258604 17200 258740 18169 257912 26361 258883 258173 23796 14608 74191 11540 57251 15550 13491 56858 258433 20609 13490 258589 259034 18217 20607 14309 64095 12772 212541 17199 15465 259036 56014 15562 21390 14427 258607 14429 19219 258333 18389 12209 14747 258475 14763 30044 194433 12425 11608 56015 18313 258776 12766 258597 76854 12672 13603 14765 257902 20605 15551 11551 12000 12801 12768 15466 11552 14761 14748 14428 18216 12061 19216 258046 11556 257959 11609 13618 14762 12802 17171 29845 258499 19204 80706 233571 258498 19214 170732 14291 11607 258500 15564 22045 12145 12669 15563 12765 17773 18442 18168 16867 81006 69296 11542 258242 15557 258594 14062 258310 12267 11553 11550 258497 14064 243764 20608 16995 258868 11549 54393 258430 258882 11548 17203 258811 14760 21462 258328 23890 14065 15565 12769 19220 15566 258434 18429 14294 12057 12771 84111 18441 12770 15559 14738 406176 140795 320463 18312 258603 19217 12773 66786 259037 258794 258269 84112 258826 18390 258415 18430 14293 18386 14290 18348 12776 258802 13051 56861 19218 14744 12426 54199 57811 58861 29849 19222 258323 259035 18387 15552 18101 69412 14767 15560 14063 19065 171469 18343 11541 18316 80885 59289 70839 11998 14539 258742 11555 18166 20132 18317 14764 18314 18167 233670 258276 258431 17202 57385 29846 12671 12273 14289 15558 12767 12774 12458 14829 258350 22095 17201 12778 Cell cycle%WikiPathways_20260410%WP190%Mus musculus Cell cycle 12545 12532 22390 12550 208727 21803 12531 17216 268930 12567 12575 12442 12649 12445 15185 12566 50496 71890 30939 19650 27214 242705 433759 18392 56150 104394 17219 15183 19650 19645 19090 66671 56452 140557 12427 18538 17127 12576 56233 12571 27401 50793 17218 12530 209091 50883 17246 12444 328572 11350 17120 105988 12428 56637 21781 12534 17217 218294 12235 12447 15182 12236 54610 12237 12544 22628 13557 15184 12448 26428 18393 13197 17215 12578 22059 13555 268697 11920 17128 18817 229776 13559 17220 17476 107995 26429 23834 245000 Hepatocyte growth factor receptor signaling%WikiPathways_20260410%WP193%Mus musculus Hepatocyte growth factor receptor signaling 107746 110157 215449 20779 14083 12928 19229 19303 14388 19211 15234 26396 218397 26411 17295 26395 109700 13712 109905 26413 18479 26419 18706 12929 20848 15461 20662 16476 14784 16412 330662 19247 26417 14281 Splicing factor NOVA regulated synaptic proteins%WikiPathways_20260410%WP1983%Mus musculus Splicing factor NOVA regulated synaptic proteins 12390 13822 225724 12558 66354 65945 16522 76707 16531 12361 26562 14406 26420 67972 18798 110351 13852 12325 54725 18007 12361 268566 13131 11804 16536 20911 269587 13823 12661 80883 57321 13640 14812 14810 11735 14806 18762 242425 13821 94332 17758 11603 12994 Complement activation classical pathway%WikiPathways_20260410%WP200%Mus musculus Complement activation classical pathway 50908 12260 50909 12259 12262 230558 17174 12263 12266 12279 110382 12274 12268 13136 625018 109828 15139 Ptf1a related regulatory pathway%WikiPathways_20260410%WP201%Mus musculus Ptf1a related regulatory pathway 18609 19664 18096 12387 15205 19130 18128 14165 18519 19668 19213 18609 Hypertrophy model%WikiPathways_20260410%WP202%Mus musculus Hypertrophy model 22388 13685 16177 18124 16175 15978 13684 22339 11910 21417 16478 17700 11487 16007 107765 56405 15200 15982 17928 16173 Heart development%WikiPathways_20260410%WP2067%Mus musculus Heart development 15214 22341 26413 17125 14179 14106 14463 12387 18091 13867 50916 19247 21388 18128 12168 57246 20893 17260 12180 12156 17300 12154 387163 14234 15213 387136 73181 16392 387161 18018 21385 22339 12166 20423 22340 14165 14465 20807 17128 15111 18019 109575 15376 12159 18741 18021 15110 Nucleotide GPCRs%WikiPathways_20260410%WP207%Mus musculus Nucleotide GPCRs 67168 11540 69296 11542 16995 11539 233571 57385 18442 18441 78134 11541 Neural crest differentiation%WikiPathways_20260410%WP2074%Mus musculus Neural crest differentiation 12162 11852 17863 16412 22408 21418 22771 18505 18509 13395 17703 17702 15221 20613 20583 22416 14365 56637 12387 21415 21413 14472 12006 12005 13544 13543 13542 12159 17125 15901 18128 13389 18132 18129 54485 18131 13388 15214 22160 20665 14173 15208 15205 19664 14182 14183 14184 65100 107771 20682 16392 12563 12558 12550 20678 23871 18033 241201 18034 18014 18935 14580 50914 50913 14618 17172 17342 18858 17528 17196 16869 16870 14179 14170 433759 15182 15183 208727 15184 15185 56233 70315 79221 170787 232232 13017 13190 12824 12815 12587 20890 15407 235472 94222 21389 15394 16873 21909 21419 140477 15110 Alzheimer 39 s disease%WikiPathways_20260410%WP2075%Mus musculus Alzheimer 39 s disease 234664 11820 11785 11487 23821 66340 19164 59287 226548 15925 17380 16956 11816 16971 14102 21937 14082 12370 15108 12122 12314 56398 12015 70405 80796 19055 19056 19057 19058 19059 70261 11491 19165 11783 12371 12367 20617 14810 12288 14811 14812 14813 14814 12289 54652 12292 14682 18795 18796 18797 18798 21926 16176 26413 26417 12364 20192 11938 11937 53313 13666 78943 226641 16438 16439 16440 12333 12334 22059 12569 18125 12568 17762 56637 12369 Serotonin receptor 2 and STAT3 signaling%WikiPathways_20260410%WP2079%Mus musculus Serotonin receptor 2 and STAT3 signaling 15558 16452 14682 20848 SREBF and miR33 in cholesterol and lipid homeostasis%WikiPathways_20260410%WP2084%Mus musculus SREBF and miR33 in cholesterol and lipid homeostasis 20787 19017 50721 15357 93759 56717 22259 19013 723897 94112 20788 16835 Serotonin and anxiety related events%WikiPathways_20260410%WP2140%Mus musculus Serotonin and anxiety related events 15558 11838 15560 15550 14281 56193 19055 18751 18802 14814 192167 12921 12918 Serotonin and anxiety%WikiPathways_20260410%WP2141%Mus musculus Serotonin and anxiety 18802 56193 18976 14816 193034 18751 12323 14265 12918 19055 13629 14394 11838 15560 14281 15550 11549 11838 13629 15558 BDNF pathway%WikiPathways_20260410%WP2152%Mus musculus BDNF pathway 18791 12064 18212 12043 327826 22059 18815 225724 12912 19353 12028 20416 12540 18053 18787 12064 18815 Striated muscle contraction%WikiPathways_20260410%WP216%Mus musculus Striated muscle contraction 21925 21956 12373 13346 21955 17897 21924 22138 13405 22003 21952 17996 21953 11465 17868 17879 22352 17883 11464 22004 11474 233199 17884 17906 326618 11472 109272 21916 17896 17885 17929 17888 98932 66106 21957 21954 11475 17901 17930 140781 59069 21393 11459 60595 71912 Purine metabolism%WikiPathways_20260410%WP2185%Mus musculus Purine metabolism 102216272 108143 18605 75686 209558 633979 73532 73532 18605 68870 215446 18770 18573 14198 242202 20020 56520 69833 667034 18577 50773 16434 20021 110385 171567 667034 210044 23984 18950 18576 14450 23959 225600 18102 18102 230718 27369 75533 76952 18968 70881 171567 18746 18573 18968 66355 67486 18577 218461 72090 76952 18969 15452 230718 230103 11636 215446 18574 11637 382985 67967 67710 103850 18950 70881 54611 15452 26939 12496 76974 72090 69745 16434 11512 18746 66358 238871 107569 20016 20020 18969 229665 78929 64424 18583 18974 18574 66401 215446 19139 71701 18950 11514 20016 667034 54369 229949 667034 230718 70881 231329 18973 241489 107569 108147 69241 16434 18584 14544 11566 18588 171567 105446 239134 54369 218461 66136 18103 54195 56520 18583 229589 667034 234889 18575 245650 20133 11821 20018 66401 67464 56520 94041 18103 72090 18584 103850 20135 70408 67054 11486 23959 18973 74414 11821 66491 66979 11514 54611 14450 230718 18972 19075 76952 12495 69745 382985 224129 18971 18950 20022 18582 79059 229363 23972 79059 207728 78801 54369 78801 76952 23972 14919 72090 11565 18102 11515 11821 67967 20135 15452 14450 20017 215446 11564 22262 14923 103850 11636 20022 18770 20018 60596 67486 69241 11486 23959 18103 14918 16434 432530 59001 18770 74414 11639 103850 54369 23971 23918 19075 13178 66979 18578 12497 20133 110385 12495 215446 12495 20019 75533 23918 66420 238871 56520 210044 79059 271639 75456 14917 59001 53893 78929 50773 231903 110639 66491 50773 20017 69920 18102 667034 76952 103850 67005 229949 76025 69870 76952 23959 12497 79059 70428 75533 19076 75533 12495 18974 29863 11534 224129 72157 18746 69870 67464 107569 18746 69833 218832 18160 11639 18950 66681 18585 76025 11515 70881 107569 50773 50773 12499 20021 104110 18950 72090 230718 18578 70881 12495 72090 18575 64424 11513 230718 22436 207728 16434 66136 245841 20019 19076 50773 11717 12495 104111 107569 11564 23917 18972 23959 103850 67005 110855 18770 23984 67054 328099 26939 215446 70408 171567 18576 11637 218832 70428 432530 231327 245841 104110 12499 23959 18971 109674 66420 66401 104111 14923 71701 67065 70881 69920 78600 107569 231329 11513 67710 271639 18587 29863 67065 23971 11512 108147 241489 74167 237823 18103 100862375 68695 Cytokines and inflammatory response%WikiPathways_20260410%WP222%Mus musculus Cytokines and inflammatory response 16175 16176 21803 16153 12504 16187 15962 16189 16163 12977 16196 15978 16183 12985 21926 16168 16191 14825 330122 16193 16160 16156 12981 16159 18590 15977 14969 Macrophage markers%WikiPathways_20260410%WP2271%Mus musculus Macrophage markers 12522 12475 12514 14066 93671 12524 16149 23833 19354 17105 Chemokine signaling pathway%WikiPathways_20260410%WP2292%Mus musculus Chemokine signaling pathway 13051 216869 66102 14710 20301 100039863 100040048 12929 14706 20299 18708 22325 56484 18747 210044 20295 56637 57349 12928 14700 18751 14678 19354 19353 16452 12540 110157 277360 20303 14697 18709 14707 12776 20306 18033 12675 14083 12988 21844 14695 18710 18798 94176 109880 12770 20308 20312 17096 18749 224129 12771 23832 19303 20416 12777 66066 56744 16453 18479 73178 20311 12927 14702 19395 20846 20418 74769 20290 18707 12775 606496 12768 110355 22324 20847 20292 26385 18797 17329 216148 320207 80901 57266 20307 20293 14679 20851 12773 271849 14708 12767 14688 26413 18762 16428 14784 18706 19877 19108 19878 19697 20662 12766 14701 100503710 14709 11513 109905 16653 16963 20663 18796 11652 12774 12772 20315 14825 17969 14699 15945 56221 14772 12458 20302 23797 12769 18795 16150 20305 15461 56838 93742 24001 20296 11651 227288 20309 57257 18176 14191 19229 14696 22376 24047 18762 20300 26417 104111 24013 104110 11514 20301 100039863 100040048 64337 11848 140580 15162 55985 14677 18035 20848 12145 541307 11515 26395 18753 14693 20304 18036 14773 215449 109689 18829 20310 16151 432530 20297 14704 12765 11512 30955 PPAR signaling pathway%WikiPathways_20260410%WP2316%Mus musculus PPAR signaling pathway 235674 19015 69050 19016 22190 74551 666168 13124 22227 26457 15360 13117 20182 11832 20250 11430 13118 30049 329065 22259 20181 328845 14080 13119 20183 20182 216739 57875 104086 74205 12140 11364 12895 78070 20181 277753 14077 100040843 14079 50790 13167 26458 26569 11807 12491 26457 14080 17436 11450 11814 433256 11770 19013 56473 20183 13122 18830 14933 103968 26459 80911 66113 93732 18534 12896 14081 16204 20182 83996 108078 26569 230639 12491 83995 225579 435802 94180 20280 20249 16956 16202 11806 14626 14077 20183 12894 20181 20411 11770 16592 74147 18607 11363 113868 Fatty acid oxidation%WikiPathways_20260410%WP2318%Mus musculus Fatty acid oxidation 15107 93747 11370 11409 52538 15107 93747 17777 11364 12896 12894 214663 G protein signaling pathways%WikiPathways_20260410%WP232%Mus musculus G protein signaling pathways 19088 14700 29863 104111 224129 14701 66066 56399 19057 11640 19085 14683 18753 14695 18577 18574 14682 14681 238871 18751 20130 14675 238276 14687 104110 218461 18176 64337 14699 14693 19084 14672 18755 19055 14677 12313 18749 19087 14697 16519 18797 432442 14674 11512 11642 18573 18575 210044 14680 18760 75292 11515 238161 432530 75547 14676 18584 83397 11848 11643 14679 219181 14710 18761 110385 14709 18754 14708 18752 14688 18750 18759 14707 14704 15461 18762 16801 56697 11514 11513 18747 18578 16653 18583 100986 14706 14673 16438 20544 14678 GPCRs peptide%WikiPathways_20260410%WP234%Mus musculus GPCRs peptide 12426 22095 21336 12776 12770 18166 26361 12061 20609 12000 17200 19065 12267 14309 18167 16867 18430 12773 12766 12145 12769 13618 12768 18386 17202 14429 18169 20605 17199 12273 11609 18390 20606 18387 21337 14428 22045 18217 80901 18101 69412 20608 14829 54140 12765 13051 17203 208188 17201 13617 12062 12767 14294 12774 12777 18389 12771 14427 12458 11608 11607 18168 12425 18216 12775 12209 14293 12772 21338 14715 20607 miRNAs and TFs in iPS Cell Generation%WikiPathways_20260410%WP2375%Mus musculus miRNAs and TFs in iPS Cell Generation 68479 70052 53607 53817 18999 20674 75062 Osteoblast signaling%WikiPathways_20260410%WP238%Mus musculus Osteoblast signaling 19226 18383 18595 21943 19228 64654 12842 218103 12097 18596 Alanine and aspartate metabolism%WikiPathways_20260410%WP240%Mus musculus Alanine and aspartate metabolism 14415 268860 226414 11484 109900 76282 18563 11898 14718 11611 14417 14719 11564 12908 107239 Spinal cord injury%WikiPathways_20260410%WP2432%Mus musculus Spinal cord injury 18053 69583 16995 24099 19283 18610 16994 18845 121021 16423 22695 14130 381833 19262 16176 18126 21926 15370 16189 12227 12566 18125 16183 16193 21898 14281 21803 13653 17381 15978 17196 68585 15139 14825 11829 11846 13838 13642 15945 12450 17395 13004 20562 20563 20564 18208 244058 12772 16177 16175 20310 20296 53357 18784 18780 16952 15894 20344 259277 14580 12567 21336 13559 19645 18750 13555 26413 12443 17869 13197 26417 12367 22059 58250 13003 12826 233781 12824 11595 12032 20682 14810 22352 19055 14432 14225 17136 11848 11853 11852 19878 18377 65079 18733 50490 387217 12534 14573 20358 14609 12064 TNF alpha NF kB signaling pathway%WikiPathways_20260410%WP246%Mus musculus TNF alpha NF kB signaling pathway 23881 69721 14113 18036 15516 72508 230233 544963 57751 12366 56489 16709 328949 19698 16648 16151 12389 20340 26401 19179 19182 12335 26410 17846 11651 13001 22627 20016 103583 18567 15519 56637 21926 26965 56456 19766 19697 71833 66997 211550 21938 22032 12905 19052 12995 22030 16650 80859 67891 18035 22196 26572 74256 22682 245841 11797 22629 109658 22034 68652 70247 56532 17463 22031 21941 446099 14082 12234 18033 21937 17218 23938 71966 192176 18616 15182 64424 21353 22631 53859 14886 14229 68052 19946 22033 219158 12367 22628 333654 56480 57783 26961 67384 18034 73086 20587 14694 18037 26405 231130 76784 19696 12675 68094 11652 26885 21934 20018 21929 54401 14084 57376 18854 12633 192656 27215 12370 11796 22036 53376 21402 16150 12539 19708 15507 66724 22029 192170 20586 76589 14388 433759 23997 23980 211651 229615 16535 26406 18747 12914 19181 70333 20779 15185 18762 216150 17220 320795 108086 20588 22218 18201 27207 14083 11647 71609 20019 12051 22026 77045 13000 22123 66413 12369 226525 20017 236733 13728 56399 18789 20846 16647 13205 19988 18637 223453 72416 19247 56407 19173 66513 Mapk cascade%WikiPathways_20260410%WP251%Mus musculus Mapk cascade 26416 16476 18176 110157 26406 26401 26417 13712 17756 26398 15461 26404 26414 26396 17196 29857 26399 20469 26413 19414 20130 11836 16653 26405 109880 26395 26397 18797 Androgen receptor signaling pathway%WikiPathways_20260410%WP252%Mus musculus Androgen receptor signaling pathway 12534 433759 11835 20779 27057 14815 15469 19645 104156 59004 13982 12017 97165 110157 20602 16476 12317 56218 217127 20848 11651 56736 12447 30051 19822 56424 12393 16195 223870 18987 23957 22196 11909 16000 17128 18193 12859 12387 14797 68098 16193 14884 12389 67655 56705 22294 66671 19211 72993 14200 98053 22215 108767 19697 13649 14600 17344 22059 268903 214230 12572 328572 11739 192176 81000 15259 26395 12362 22634 17978 12189 13983 22026 21815 229615 12531 83995 12370 21674 12367 12369 193740 18813 26423 225115 11614 12914 12443 17977 17246 22629 19384 19303 56469 21804 17979 17127 170758 20683 81601 18986 26413 68705 107951 20466 19183 232286 12394 12539 Primary focal segmental glomerulosclerosis FSGS %WikiPathways_20260410%WP2573%Mus musculus Primary focal segmental glomerulosclerosis FSGS 16410 21898 12323 11651 13429 67703 16416 22330 16449 243911 17973 12476 13039 19277 16776 13380 14360 18793 14083 54139 22370 22630 104027 21803 11603 12488 16691 170484 16779 54631 18803 12576 12946 18504 27205 16917 71602 12492 14107 192897 12830 12577 17380 22352 12575 74055 60595 17886 54380 22431 70435 22068 18538 17345 12558 12737 12828 12829 110829 12519 18128 12387 16974 16973 21894 16202 16412 16400 13138 57342 22288 TGF beta receptor signaling pathway%WikiPathways_20260410%WP258%Mus musculus TGF beta receptor signaling pathway 12234 21813 13018 13559 11910 18519 16477 17260 216080 108058 21417 19877 16476 19651 18046 54601 24136 71770 13805 17127 21814 21402 218210 217232 12567 104394 12393 12387 19645 12575 21812 19087 66354 26416 15228 52206 18045 14106 17131 216869 66313 69957 56438 75901 17126 16842 26399 21781 21803 68999 22062 22601 17869 12443 26965 22337 20683 59008 230597 69150 20482 56317 12389 21809 103573 14225 18708 14272 17128 75788 12505 18709 99152 26754 386655 12534 17344 13163 11909 23871 21815 12914 71728 14281 76793 21808 11835 72183 20869 14282 227720 18753 26419 19650 13542 56371 15405 16478 18751 17130 66513 52563 20481 26397 328572 66105 211586 12005 20901 15481 76630 93742 16211 13132 22218 15239 12442 13982 17258 12530 56550 54709 12006 19085 15529 12571 17222 56469 67804 12447 26409 56484 11482 56440 18044 17977 67903 68015 56458 59079 12566 71978 433759 12323 12322 12325 22059 15378 20692 12705 Delta Notch signaling pathway%WikiPathways_20260410%WP265%Mus musculus Delta Notch signaling pathway 18128 18129 18131 18132 13388 54485 16449 16450 19164 19165 208117 66340 59287 11487 11491 56637 18222 16396 11820 18223 18708 18709 11651 18550 12805 18133 14357 17172 328572 22059 16848 17305 140484 21402 50754 15213 270118 433586 103806 66354 20602 20185 433759 66935 60406 15182 20466 15205 20848 16452 19697 18035 15214 21885 17127 17128 22632 12566 16842 17260 26965 27401 21423 26417 26413 57750 14199 19763 16656 56381 17125 55927 22761 17137 12804 12803 15208 16818 16476 19664 13645 13649 Ovarian infertility%WikiPathways_20260410%WP273%Mus musculus Ovarian infertility 12167 19116 14309 16867 22788 13404 11920 17350 17687 14566 22787 20597 13164 14612 16322 17127 18667 13983 22337 26423 21374 20185 268903 13653 12608 19217 12576 12444 12567 13075 319565 B cell receptor signaling pathway%WikiPathways_20260410%WP274%Mus musculus B cell receptor signaling pathway 13712 15184 18021 14784 12444 26413 19058 11909 77799 18719 76709 12483 14389 19697 12042 218397 22324 107746 18604 72508 83490 13448 18718 18760 14388 68089 56743 18019 56233 20846 19264 12371 16439 12572 12571 15162 30955 16822 110157 14360 11867 26377 18803 17164 19645 66713 20848 12369 12518 22637 12912 208650 15163 26395 19247 16151 20111 117150 18709 68119 76108 18753 12053 16331 20963 12478 16150 12387 109880 14083 242248 12229 19696 56458 27261 77590 12902 12927 12929 17096 108723 12567 16438 18751 83436 26411 18720 11651 20663 12445 23921 18003 381290 56792 108083 12675 12125 26396 24055 12517 12928 18035 26419 240168 18754 67603 20662 15170 12988 12143 16818 12566 14886 11848 12028 225724 16476 18018 22325 18708 21682 319520 14130 74117 19229 234779 18761 12520 101476 17973 606496 16428 18607 22376 56637 15387 12402 26409 19253 12507 20104 12043 20416 72699 26417 12428 56378 15985 19055 67771 17060 26416 12447 19056 18717 Focal adhesion PI3K Akt mTOR signaling pathway%WikiPathways_20260410%WP2841%Mus musculus Focal adhesion PI3K Akt mTOR signaling pathway 12826 22084 53867 21828 19116 20662 12831 16420 105083 16453 16186 319480 12815 16780 14784 329278 20869 14599 16188 13857 16404 16409 12843 216505 15891 12832 18414 94216 21827 16398 16773 12824 12829 12985 192897 16402 16775 320910 381924 16416 16776 14083 12643 213119 81877 16400 12842 16403 13856 16410 16772 22371 12825 23797 16411 16414 16190 16399 12986 15976 23928 16197 21826 16421 15965 20750 14268 74747 12814 16401 16452 16451 22370 15962 15964 11651 74769 18707 14600 16194 12845 226519 16779 16185 18706 16774 16184 19211 16777 19699 75669 12827 64930 16412 241226 16407 104099 12834 16419 21825 16408 11652 18708 18709 16782 21923 15975 21960 320207 13636 14164 14166 14165 13637 13645 14167 12977 11602 11601 11600 22339 13638 13639 13640 14169 14168 14170 14171 14172 14173 14174 14175 14177 14178 14179 14180 14205 15234 16000 16333 16334 17311 22341 22340 18591 18654 18590 18049 54635 56636 67112 71785 80857 80903 14183 16542 16337 14184 16001 16590 14182 13836 13649 12978 14186 14254 14257 18053 17295 18595 18596 21687 67605 15967 15968 15969 15970 15972 15974 15977 16183 18413 19109 230396 404549 12669 14745 14062 243764 381810 53978 65086 67168 78134 14693 14688 100503710 14696 14699 14700 14701 14695 14702 14704 14706 14707 14708 14709 14710 64337 66066 30955 18176 16653 15461 72149 12283 69008 105787 108079 56716 19744 56717 74370 15251 22241 74343 12539 15516 98432 21432 18607 100039815 19053 19052 100039830 21770 225849 72930 73699 19054 235542 26931 26932 269643 51792 52432 226849 59032 15519 22027 244650 17763 27379 27380 110157 26396 26395 26413 26417 56637 56484 56458 16150 12015 12371 17246 16151 12576 12575 11909 12913 12912 11911 208647 208677 12915 26427 78284 231991 18127 57915 17274 59021 19325 19326 68365 20528 20525 20527 20526 19017 14936 232493 18640 18639 170768 270198 16890 20787 15375 107476 15568 18125 18126 13819 53417 58988 13685 75705 72508 20104 13684 26987 218268 240752 18704 18705 16367 16370 16369 384783 Gene regulatory network modelling somitogenesis %WikiPathways_20260410%WP2852%Mus musculus Gene regulatory network modelling somitogenesis 14179 21389 382089 17293 13838 84653 15205 16848 18128 13388 22416 White fat cell differentiation%WikiPathways_20260410%WP2872%Mus musculus White fat cell differentiation 22410 13591 20787 12606 12608 14013 19883 13198 12912 54131 20851 66277 12224 14461 21415 94187 13654 14462 11819 19016 22259 12609 12385 16600 19401 56458 20850 21887 16333 14815 16364 16598 Notch signaling pathway%WikiPathways_20260410%WP29%Mus musculus Notch signaling pathway 19664 16449 433586 14357 15182 13544 11491 13017 18131 103806 13543 13542 66935 59287 226548 19668 18128 20602 18222 209200 13388 66354 19165 54485 18129 18132 12914 80904 74198 15205 18519 207521 16848 433759 16450 19164 13016 13389 17305 18223 21926 19719 19208 208117 14534 15208 p53 signaling%WikiPathways_20260410%WP2902%Mus musculus p53 signaling 11920 50883 245000 12649 12578 17246 17248 22059 12575 12443 12444 12445 12567 12571 12447 12448 12566 55948 67874 268697 12442 209091 434175 12534 13197 17873 23882 29870 14102 57913 12370 12122 12028 58801 170770 13663 66940 64058 22401 20437 20438 13063 13067 11783 12371 12367 16009 16000 18787 107831 12521 21825 20724 107986 382985 20135 140742 230784 75747 19211 22084 68428 26374 68098 12450 12452 53892 22062 miR302 367 promoting cardiomyocyte proliferation%WikiPathways_20260410%WP2904%Mus musculus miR302 367 promoting cardiomyocyte proliferation 15235 50523 68473 22601 Mecp2 and associated Rett syndrome%WikiPathways_20260410%WP2910%Mus musculus Mecp2 and associated Rett syndrome 20185 17932 18996 11813 14175 12064 18015 20604 27528 53618 17257 18992 22608 14174 13006 14810 17260 21354 268859 12799 14056 14431 18387 622434 20466 20683 14415 270627 59013 13007 13395 57810 17932 12609 17196 12053 14409 13018 20687 70767 13555 19712 17136 14173 26913 52463 98758 22608 12912 miR 222 in exercise induced cardiac growth%WikiPathways_20260410%WP2928%Mus musculus miR 222 in exercise induced cardiac growth 12576 219150 15258 15257 Electron transport chain%WikiPathways_20260410%WP295%Mus musculus Electron transport chain 11946 230075 11958 11740 226139 110323 66152 12864 57423 28080 67942 66377 11947 68375 66594 66091 20523 72900 67130 17709 66218 407785 66694 17991 17720 17706 595136 12858 67003 11957 67680 17708 20463 75406 12861 74011 17993 12865 12857 27425 22229 66576 66108 66495 100041273 68194 100042503 12866 17722 68055 66945 17717 70316 66142 22272 11739 67530 17721 66414 52892 66925 11983 66916 54405 22273 66046 12859 17705 17710 68349 12868 17716 17995 66052 228033 12862 20930 227197 66416 17719 71679 68197 68198 226646 66043 68342 12856 17992 68202 11950 67126 11949 78330 67273 22228 17718 225887 17711 22227 IL 7 signaling pathway%WikiPathways_20260410%WP297%Mus musculus IL 7 signaling pathway 12125 12028 16362 20416 20844 12428 17829 14360 17096 20846 17210 20850 11651 16186 12567 208650 15461 12444 20662 16451 56458 26396 19229 26395 384783 16197 12402 18708 110157 12566 12143 12015 20848 26413 16453 16367 26417 19645 56637 14784 20851 67300 56484 56324 G13 signaling pathway%WikiPathways_20260410%WP298%Mus musculus G13 signaling pathway 20166 320795 12632 52428 11848 18643 16801 24068 14674 544963 29875 18707 11857 74769 59009 16885 53311 19353 51789 18481 18718 26414 12313 73178 18709 19046 22376 26407 17901 12704 14570 19877 13367 18706 12540 72508 19878 12631 Histone modifications%WikiPathways_20260410%WP300%Mus musculus Histone modifications 107435 433759 15182 77683 110147 Translation factors%WikiPathways_20260410%WP307%Mus musculus Translation factors 22384 13628 13690 224045 217715 26905 19106 13629 217869 55949 20918 68135 16341 13631 16418 13667 225363 13681 13682 13688 18458 13669 66656 13664 75705 13685 208643 78655 13665 66085 26908 276770 53356 108067 13684 209354 54709 56347 218693 230861 13627 18459 55944 108112 13666 67160 15467 67204 27979 mRNA processing%WikiPathways_20260410%WP310%Mus musculus mRNA processing 20020 74111 18139 68035 110957 22184 66679 237073 19847 20822 101943 207920 15382 67579 66055 24128 15547 20658 29813 234373 13206 66492 56417 20462 66164 109729085 67053 24014 117903916 27366 109075 66405 76167 72160 21744 12877 24018 75420 19848 19941 27041 68219 19653 69597 19826 74326 50926 102462 50911 57320 76938 76572 53610 67671 67456 19989 20624 66704 319695 20641 234733 53607 93728 53356 69207 20638 14030 20595 241490 66446 228410 54127 71713 246730 243272 20005 216578 70616 19106 321006 268859 72567 56031 69724 19845 67248 19357 23879 94191 71514 233908 231769 244631 100336 70233 235402 66585 66475 18789 108014 19657 229279 13205 12021 70052 58203 13164 80912 19134 68379 14007 140486 104307 56381 67842 19934 67949 19844 56190 192170 217337 56195 224344 68879 68278 384281 66185 18458 72935 15568 20630 67337 20853 20637 20639 17184 12748 13046 56009 66983 68598 20826 104721 338351 53890 12828 14962 319322 19862 115489655 66230 68092 13682 13211 27225 319586 56194 67936 108013 19017 72459 218543 52874 68172 20646 71713 70439 110809 107951 229279 77604 67197 83675 115488065 115488060 19842 18938 20090 57317 217207 75710 19844 320158 98985 68165 16201 15387 21843 239188 67418 77411 52521 192159 30959 23962 72735 98685 68479 246277 23983 69639 67434 20817 26961 353258 236732 57294 27275 27993 50783 19656 11428 22384 53379 230257 83410 66892 71766 170826 102857 21357 245945 193116 69192 269261 70044 12696 66599 230721 230603 15572 12189 67120 67025 229663 20821 19383 13690 272009 20975 15388 76626 26919 70930 27979 67710 67920 20823 77134 15469 16865 22034 52202 26987 19951 209224 67427 67465 381626 207181 13684 215615 53817 140488 51796 53975 18521 56758 72662 27756 78784 56215 53319 246727 231413 66094 20044 68272 108121 102414 19663 70767 230908 20088 22185 12750 64340 15571 20383 109095 11640 269061 69207 20826 19654 21752 75062 67667 54614 98758 213236 60365 51810 56316 11992 56258 56516 18459 20222 115488065 115488060 19842 20747 170722 16589 54451 11739 19205 27058 22380 14359 107686 23960 76897 217351 67010 19655 170791 66810 19935 74484 100861987 81898 69408 114896 53621 67959 71684 18542 51786 15569 20102 107701 224902 232089 230861 76846 67229 94230 13722 20384 68195 13680 11499 66419 20815 69878 66645 66660 66384 19921 68052 14265 59093 78304 73826 56335 67039 27998 72290 14208 72397 74213 106583 72054 246728 67390 100121 171190 59013 83410 67897 208606 13209 19652 100043257 75388 24067 24061 15468 56403 67889 80913 70248 21841 19317 13204 68011 76522 67207 71973 76938 19848 108657 380773 18670 68581 20813 100502825 67281 13207 15381 208718 56200 14105 14113 20382 54196 23961 67543 15384 53609 59092 67958 52513 17690 20462 208922 57837 11991 30947 56275 19845 108062 20238 20643 22099 21681 76183 67332 76936 67996 20115 54188 68744 66125 22608 218543 17975 27632 225027 56878 27207 20104 18148 192119 209003 53791 68981 67225 19656 20924 83486 20492 93871 67444 17876 12747 72692 56522 93686 Glycogen metabolism%WikiPathways_20260410%WP317%Mus musculus Glycogen metabolism 19309 19053 102093 232493 225849 68961 26931 12313 18679 269643 110078 216558 14936 606496 235542 27357 51792 12315 26932 19052 21770 72930 77559 226849 12314 110094 71978 56637 18682 73699 74185 72157 110854 110095 Eicosanoid synthesis%WikiPathways_20260410%WP318%Mus musculus Eicosanoid synthesis 11690 19215 96979 13479 19223 18780 11689 21391 19224 14598 53357 11687 11688 64292 16993 19225 17001 67452 11684 GPCRs class C metabotropic glutamate pheromone%WikiPathways_20260410%WP327%Mus musculus GPCRs class C metabotropic glutamate pheromone 14816 108071 108068 108069 14823 268934 108073 108072 12374 54393 242425 93746 70355 64297 232431 Fatty acid omega oxidation%WikiPathways_20260410%WP33%Mus musculus Fatty acid omega oxidation 26876 13106 11529 13077 11668 320092 11669 13076 11522 Fatty acid biosynthesis%WikiPathways_20260410%WP336%Mus musculus Fatty acid biosynthesis 14104 93747 433256 111175 52430 107476 52665 50790 20249 60525 67856 104112 74205 15107 100705 14081 18563 52538 26922 67460 216739 51798 ESC pluripotency pathways%WikiPathways_20260410%WP339%Mus musculus ESC pluripotency pathways 14368 23797 13544 66713 17125 56637 17129 17869 15461 12166 109880 18590 22415 14164 17131 22419 80903 18591 14177 14170 11477 14182 26395 12387 14366 67112 13542 16451 12168 16476 14165 18707 14180 14370 20848 20662 80857 11652 110157 14166 22421 14371 16195 14184 22418 23939 57265 14171 14367 93735 14172 14369 14362 13649 17246 22409 14186 14183 18595 26413 18121 11836 56717 17128 22422 55994 26397 20363 16878 16880 22413 23938 18709 16973 22412 12005 13712 14169 22416 12167 50772 19247 64654 14176 14388 19211 22411 14784 13543 11789 11651 21405 22417 17130 14173 22408 225724 14167 56636 22420 13645 29857 14365 22410 18596 14281 14174 14168 26399 26396 14178 12159 14179 353283 14175 22414 16974 p38 Mapk signaling pathway%WikiPathways_20260410%WP350%Mus musculus p38 Mapk signaling pathway 17164 14784 22030 15507 20416 26399 338372 19353 21812 17261 11909 20846 12912 26408 17346 26409 19766 73086 26416 13712 17187 15461 12540 15312 18783 26398 13198 19417 21808 13163 26401 17869 71609 GPCRs small ligand%WikiPathways_20260410%WP353%Mus musculus GPCRs small ligand 17773 12802 19216 19217 14739 19219 13610 13609 12801 21390 19204 14745 19222 19214 19218 13611 244701 19220 Fatty acid beta oxidation streamlined %WikiPathways_20260410%WP3588%Mus musculus Fatty acid beta oxidation streamlined 14079 97212 12896 11364 231086 15107 14077 13177 11370 433256 225579 11363 14081 57279 216739 12894 14080 12895 12491 12140 50790 11409 67460 110446 11770 93747 74205 26457 26459 26458 26569 26568 ApoE and miR 146 in inflammation and atherosclerosis%WikiPathways_20260410%WP3592%Mus musculus ApoE and miR 146 in inflammation and atherosclerosis 18034 11816 19697 387164 20375 16179 21898 22034 24088 Tyrobp causal network in microglia%WikiPathways_20260410%WP3625%Mus musculus Tyrobp causal network in microglia 27060 99586 67742 16164 14775 16409 668218 76448 80719 66824 105855 20514 338355 67963 66102 22177 15284 12504 239273 20540 245945 54519 12262 16414 216991 217203 12332 20850 56501 20111 20750 208647 12193 12399 56193 224109 17095 16950 12266 17970 238875 12493 21812 330217 12523 16411 78416 15163 16154 16923 231162 21938 50778 16173 57442 108735 17132 218454 Microglia pathogen phagocytosis pathway%WikiPathways_20260410%WP3626%Mus musculus Microglia pathogen phagocytosis pathway 15162 12259 22177 20963 18708 83382 58217 14127 14129 16409 83433 58218 16414 17096 15170 234779 16797 19353 19354 170758 22324 22325 57257 105855 11867 17972 17970 17969 13058 13057 12260 12262 30955 18706 18707 74769 18709 225326 18704 104709 18710 Lung fibrosis%WikiPathways_20260410%WP3632%Mus musculus Lung fibrosis 269400 20310 20750 224897 14164 20303 17131 14219 74108 20296 20482 21926 20387 16193 13614 13717 12985 23892 109620 21752 17257 20309 108689 12310 21802 16163 16176 12771 20304 18590 20292 50770 14173 17228 16191 13645 21857 16160 12162 18591 19288 18024 17395 14178 74180 12608 70086 15368 17390 15234 20389 12772 16189 12981 244548 18792 58909 20302 17750 16000 21803 Parkinson 39 s disease%WikiPathways_20260410%WP3638%Mus musculus Parkinson 39 s disease 107508 13195 13162 22223 50873 20617 21823 66725 68943 57320 64704 13063 14763 18951 67847 22187 22201 74153 22195 56791 140499 67128 22213 56228 20239 229521 12447 12448 29857 19094 26416 26415 12368 12371 12366 13063 12369 12367 11783 Ectodysplasin A signaling in hair follicle development%WikiPathways_20260410%WP3652%Mus musculus Ectodysplasin A signaling in hair follicle development 18033 19698 18034 19698 16994 18033 13608 19697 234130 66042 19697 171211 13380 14632 19206 20423 13607 13607 Novel Jun Dmp1 pathway%WikiPathways_20260410%WP3654%Mus musculus Novel Jun Dmp1 pathway 13406 11840 16653 16477 26413 12578 110157 17869 12567 12443 13555 19645 23871 26395 23872 16476 22059 17246 20130 18176 15461 11836 109880 26396 26417 14281 BMP signaling pathway in eyelid development%WikiPathways_20260410%WP3663%Mus musculus BMP signaling pathway in eyelid development 14165 14183 16324 21802 20423 12159 20377 17125 17129 17128 18741 56811 17300 14234 18128 26401 26420 16476 13649 26417 Hfe effect on hepcidin production%WikiPathways_20260410%WP3673%Mus musculus Hfe effect on hepcidin production 15216 71753 69585 84506 12161 17131 15901 Factors and pathways affecting insulin like growth factor IGF1 Akt signaling%WikiPathways_20260410%WP3675%Mus musculus Factors and pathways affecting insulin like growth factor IGF1 Akt signaling 17127 19017 56458 17126 19079 17700 21950 11651 16412 21937 433766 16367 18805 16202 228026 56717 72508 21926 19211 16001 16000 16011 11481 56717 18033 16006 16009 16010 16008 29817 16012 104771 IL 1 signaling pathway%WikiPathways_20260410%WP37%Mus musculus IL 1 signaling pathway 16180 19261 67245 16179 108960 26413 266632 53859 18035 26395 12675 26409 19697 16176 16175 22034 16177 16181 73914 16175 26417 12333 266632 68652 18803 18762 66513 18033 12336 18036 16178 19247 26419 12362 18412 230233 16176 54473 11651 17874 IL 3 signaling pathway%WikiPathways_20260410%WP373%Mus musculus IL 3 signaling pathway 16187 20846 110157 20850 14128 20525 56461 12402 15170 11909 20416 23939 16452 19303 22631 22330 20852 14388 21682 54721 17179 26413 14083 18707 14461 18708 17096 12015 12125 14784 12983 20662 11908 22324 12649 12928 16451 20848 18750 15901 14694 26419 14389 20851 18747 12169 16818 54401 26417 13429 11799 26416 16188 19052 11651 18033 58988 56637 21938 12043 20375 18751 14460 17532 16653 17395 19247 12912 109905 19401 20963 20779 18706 12028 17164 12700 18709 26420 15507 16331 12929 14159 15461 19354 107746 20344 606496 56458 18479 216233 20181 26395 15162 17390 12702 19353 12048 12540 14360 Prostaglandin synthesis and regulation%WikiPathways_20260410%WP374%Mus musculus Prostaglandin synthesis and regulation 13617 19225 13618 19223 20194 19109 15446 20200 11745 21391 11752 19222 11747 15483 18783 19224 19215 16952 19214 13070 11746 19216 15484 19219 19220 11749 22287 19217 19218 12306 13614 Myometrial relaxation and contraction pathways%WikiPathways_20260410%WP385%Mus musculus Myometrial relaxation and contraction pathways 51801 16012 64337 50782 18762 224129 20190 53313 11911 19088 18752 210044 18754 16011 14772 14695 14704 18768 14281 14773 18430 228785 14701 19735 14702 50779 16476 104111 14708 18749 12915 54409 11536 12310 11514 432530 216869 11908 18125 56533 18755 20191 64214 54401 16193 26385 12909 381489 12797 22629 12325 24012 17896 50778 18751 14745 56089 108058 18761 18127 109624 14873 12918 18750 22631 19087 14693 66066 18430 16010 20192 67865 104418 19737 11938 16008 58175 14682 14697 22627 18429 19084 19739 55948 11513 107503 234779 16176 14707 11535 19734 16440 18760 11465 14709 140498 14696 19085 56470 11461 53419 14391 18753 20683 14390 11512 14915 16438 12323 12921 19773 238871 23872 11910 104110 18799 19736 51791 20541 14916 109689 14609 22628 12297 12778 16006 18769 18578 14699 18767 22630 12913 11464 16009 18803 14683 17133 12315 11909 14706 11515 11459 14688 17906 50780 16439 18797 12322 18033 12912 60596 Dysregulated miRNA targeting in insulin PI3K AKT signaling%WikiPathways_20260410%WP3855%Mus musculus Dysregulated miRNA targeting in insulin PI3K AKT signaling 12825 14252 12843 12444 56717 53867 20662 12703 14104 107476 12125 26987 19108 12929 12827 26417 18710 53413 12043 12015 18708 12842 19744 12576 19087 110157 Wnt signaling in kidney disease%WikiPathways_20260410%WP3857%Mus musculus Wnt signaling in kidney disease 216799 11848 12387 16348 16973 228357 22408 22409 22410 22421 93735 22420 22418 22414 22411 22417 22416 22419 22412 22413 22415 22422 14362 14370 14366 57265 14369 14371 14367 14368 14365 13543 13544 13542 26420 26414 26419 56637 12005 17311 93687 11789 12234 Triacylglyceride synthesis%WikiPathways_20260410%WP386%Mus musculus Triacylglyceride synthesis 15450 14555 67512 14732 66853 67800 228061 16890 16956 233549 52123 68393 68262 50784 14712 67717 13350 14933 67916 14626 19012 55979 28169 Robo4 and VEGF signaling pathways crosstalk%WikiPathways_20260410%WP3864%Mus musculus Robo4 and VEGF signaling pathways crosstalk 74144 20563 16542 19353 22339 20779 IL 6 signaling pathway%WikiPathways_20260410%WP387%Mus musculus IL 6 signaling pathway 269643 56458 16194 18708 26395 19229 14159 235542 20848 12371 14388 26931 107951 18709 17977 17164 56637 12702 26399 12367 20416 20850 19053 12608 16193 20662 13867 16195 229317 14281 13866 26416 19052 12015 73699 19303 20846 16476 12229 14360 26413 14784 26409 433759 12569 19247 11651 16451 20393 21405 16331 11835 18033 13163 110157 26419 72508 54721 17762 15461 14083 26407 71978 21939 20112 14191 26417 18803 19645 72930 22324 21682 20851 16332 15507 13685 14389 26396 21770 19353 15519 328572 16452 54601 226849 51792 26398 12169 13684 225849 18099 12914 18753 110854 15162 56484 12568 17096 26932 ACE inhibitor pathway%WikiPathways_20260410%WP396%Mus musculus ACE inhibitor pathway 11421 16644 11609 11607 19702 19701 18127 11606 12062 mir 193a and MVP in colon cancer metastasis%WikiPathways_20260410%WP3979%Mus musculus mir 193a and MVP in colon cancer metastasis 27041 53872 78388 17869 12443 12444 miR 127 in mesendoderm differentiation%WikiPathways_20260410%WP3991%Mus musculus miR 127 in mesendoderm differentiation 320202 387146 11477 12627 17126 18119 11480 17128 15376 20997 21331 Mitochondrial long chain fatty acid beta oxidation%WikiPathways_20260410%WP401%Mus musculus Mitochondrial long chain fatty acid beta oxidation 50790 20280 12896 74147 14081 13177 11409 97212 12894 74205 11363 11364 11370 15107 57279 111175 Wnt signaling%WikiPathways_20260410%WP403%Mus musculus Wnt signaling 13544 11848 19353 18792 18751 18755 14296 56637 11789 22416 14365 26420 27373 12443 16835 14370 18760 22421 22411 22408 18750 16476 93897 14369 26931 22419 12387 22413 18754 22414 20379 18752 18472 13543 22420 12445 22418 14362 93735 14368 22417 26932 22415 12005 22410 18761 14367 22422 13542 18759 22409 14283 26414 17869 18762 12444 14371 30050 18753 57265 Kit receptor signaling pathway%WikiPathways_20260410%WP407%Mus musculus Kit receptor signaling pathway 14786 18708 18709 20416 12983 14784 54607 67296 56468 12700 67300 12928 20779 74055 16452 71520 19273 56792 18750 18803 20846 20850 20851 30955 23921 14783 11651 21682 17096 13448 15170 19247 13857 20111 17342 26413 11350 16331 14191 15162 22612 218397 14159 12929 12402 12703 22324 22325 17179 12015 20662 328572 14360 18751 15461 110157 114716 114715 58194 208650 21933 12229 16590 17311 26395 20848 17475 GPCRs other%WikiPathways_20260410%WP41%Mus musculus GPCRs other 319757 12614 18343 81014 14608 18329 259009 15550 12311 56696 18356 171469 80978 170732 113858 18315 113863 69296 11542 13617 107934 113845 18323 18387 22312 57260 213527 18321 18354 81011 18350 11554 14371 218066 78249 18344 81016 18322 113859 18390 257890 113853 66786 113846 18324 18361 18359 13489 233670 80910 259044 14367 53883 14816 18363 113849 258923 113864 58182 11539 76206 113862 27216 14788 259007 18316 258702 18352 18372 21338 18349 12801 258703 18241 17202 11555 81015 80290 64378 20609 64379 18332 26364 18317 113851 13488 12777 58861 18310 113854 18330 15552 14369 258435 18362 14766 23890 113855 13349 81013 22311 20132 18341 18389 18373 18357 13609 259115 14739 57265 13492 113856 110326 24112 54393 81012 113860 258153 18328 12374 22296 258859 208188 404316 113857 81010 18347 18331 18345 81017 22313 18351 258706 22354 113850 18358 113848 14362 113852 113847 258343 29848 170648 258326 258826 113865 244701 94226 22297 23832 71111 18346 12775 18307 Oxidative stress response%WikiPathways_20260410%WP412%Mus musculus Oxidative stress response 394436 26462 14281 13057 17161 20683 26416 26414 13076 14872 18032 12359 14782 20657 14778 14629 17748 18104 50493 20656 15368 16477 14391 14775 18033 56615 20655 56551 G1 to S cell cycle control%WikiPathways_20260410%WP413%Mus musculus G1 to S cell cycle control 12567 12571 12443 12444 12445 12575 12576 12572 66671 13555 242705 13557 19650 19645 104394 13559 50496 21781 211586 12566 12447 12448 18974 18973 12530 22390 268930 12534 12544 19891 68240 68275 17216 17215 17217 17218 17219 17220 18392 18393 50793 26428 26429 56452 19075 19076 18969 18538 22059 13197 17246 12580 12579 12581 12578 12427 11920 12577 12452 17869 17420 Distal convoluted tubule 1 DCT1 cell%WikiPathways_20260410%WP4183%Mus musculus Distal convoluted tubule 1 DCT1 cell 16517 69847 12283 53416 232341 56365 20497 Ethanol metabolism resulting in production of ROS by CYP2E1%WikiPathways_20260410%WP4265%Mus musculus Ethanol metabolism resulting in production of ROS by CYP2E1 26419 13106 20683 26396 17133 17134 26395 17135 18024 18753 Nuclear receptors in lipid metabolism and toxicity%WikiPathways_20260410%WP431%Mus musculus Nuclear receptors in lipid metabolism and toxicity 11303 19013 12780 19016 18171 27413 19401 13124 13077 27409 11307 13082 12355 22337 76408 13088 13122 218772 13115 19411 13120 18670 13081 22259 18671 20186 13106 26874 19015 69050 19299 Eicosanoid lipid synthesis map%WikiPathways_20260410%WP4335%Mus musculus Eicosanoid lipid synthesis map 18784 53357 18783 211429 74451 19225 64292 19215 11689 TCA cycle%WikiPathways_20260410%WP434%Mus musculus TCA cycle 18563 18597 68263 27273 170718 27402 235339 13382 66945 17449 20917 11429 381511 56451 78920 18604 15929 66052 228026 66925 67680 12974 20916 67834 236900 269951 18293 18598 382051 14194 17448 Sphingolipid metabolism overview%WikiPathways_20260410%WP4344%Mus musculus Sphingolipid metabolism overview 19012 223753 81535 11886 208449 56632 20397 22234 268656 20698 13244 70750 20773 67260 67260 241447 20597 70059 74442 67916 22239 93898 14559 76893 545975 433323 Glycerolipids and glycerophospholipids%WikiPathways_20260410%WP4345%Mus musculus Glycerolipids and glycerophospholipids 14732 19012 66586 212862 68671 74596 320951 13350 27388 66853 18805 104418 19210 18618 68262 52858 12651 13026 75320 102247 67800 18778 116939 Cholesterol metabolism with Bloch and Kandutsch Russell pathways%WikiPathways_20260410%WP4346%Mus musculus Cholesterol metabolism with Bloch and Kandutsch Russell pathways 20787 110446 11303 12642 15357 13122 22259 20652 14104 13360 235293 13595 73166 13116 104086 223920 110460 208715 15360 17855 68603 192156 20775 319554 320581 14137 14593 110196 16987 74754 22260 11307 218203 20788 14081 74205 50790 26897 171210 18194 74754 54326 12686 83603 68801 76267 56473 20249 20250 13121 73166 66234 98386 15490 18194 Eicosanoid metabolism via cyclooxygenases COX %WikiPathways_20260410%WP4347%Mus musculus Eicosanoid metabolism via cyclooxygenases COX 19223 21391 15446 18784 19015 69050 53357 18783 211429 19224 19225 64292 19215 11677 67103 77219 13117 277753 13118 64385 72054 11430 93732 80911 113868 74147 19222 66469 19220 19214 14764 21390 19224 Eicosanoid metabolism via lipoxygenases LOX %WikiPathways_20260410%WP4348%Mus musculus Eicosanoid metabolism via lipoxygenases LOX 13117 16993 211666 625249 72054 14775 11689 66447 11687 15446 13850 17001 277753 13118 64385 72054 11430 93732 80911 74147 113868 14598 23887 13479 319446 11684 67103 77219 Eicosanoid metabolism via cytochrome P450 monooxygenases%WikiPathways_20260410%WP4349%Mus musculus Eicosanoid metabolism via cytochrome P450 monooxygenases 13850 13117 277753 13118 64385 72054 13095 13096 13097 13098 13099 226143 404195 72082 13109 19013 One carbon metabolism%WikiPathways_20260410%WP435%Mus musculus One carbon metabolism 108156 69606 13433 14450 13436 13361 11720 12116 108645 108147 14317 21452 17768 434437 108037 238505 53320 77683 269378 20425 270685 13435 17769 210009 110147 107747 74340 22171 107885 Omega 3 omega 6 fatty acid synthesis%WikiPathways_20260410%WP4350%Mus musculus Omega 3 omega 6 fatty acid synthesis 56473 14081 74205 50790 54326 68801 76267 11430 80911 26897 171210 74205 50790 18784 53357 18783 211429 Omega 9 fatty acid synthesis%WikiPathways_20260410%WP4351%Mus musculus Omega 9 fatty acid synthesis 76267 14081 14104 74205 50790 54326 68801 170439 12686 54325 20250 56473 26897 171210 PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine%WikiPathways_20260410%WP4398%Mus musculus PDGFR alpha and STMN1 cooperate to exacerbate cytotoxic effects of vinblastine 18595 16765 Matrix metalloproteinases%WikiPathways_20260410%WP441%Mus musculus Matrix metalloproteinases 26561 234911 17390 17385 17388 240047 17395 17392 118453 21858 17393 17384 23948 58223 12215 17381 17389 21411 17387 214766 30800 21857 17394 17386 21859 17391 21926 83995 110595 Oxidative stress and redox pathway%WikiPathways_20260410%WP4466%Mus musculus Oxidative stress and redox pathway 14780 18477 22166 50868 332309 12505 14854 75475 20511 26570 20371 14873 14870 14775 20514 433899 625249 14776 14381 14664 14629 18024 11689 18181 14871 14857 14782 12411 15926 56615 14863 14660 14630 110175 14778 75512 67305 69590 269951 14380 110208 14872 103140 14862 14864 14865 14866 14867 68312 14858 14859 14860 14869 68214 211666 66447 54486 76263 23887 71522 207182 14598 12780 27416 66988 16790 104245 28248 24059 12477 13058 13057 19353 17972 17969 17970 21672 11757 53381 54683 11758 320769 19224 19225 20201 20202 20655 20656 20657 50493 26462 232223 Adipogenesis genes%WikiPathways_20260410%WP447%Mus musculus Adipogenesis genes 20378 27217 22410 20185 13591 13865 14362 16334 16370 22408 116939 20787 16369 15251 20183 20181 12606 18196 20683 12153 12608 12387 17873 21405 230709 13819 228775 17977 268903 20602 11606 16846 14705 20528 16905 12156 19883 13555 12159 14463 14560 16878 13198 16890 12912 19223 16880 13197 13542 14102 52637 93691 11622 17319 57264 67512 20851 12804 18534 13046 20847 66277 14234 19651 18787 12224 17260 19645 20848 17984 110075 14461 17127 11537 232174 20852 16193 20745 14599 21803 11450 15903 22419 13654 59027 14462 56758 11604 11520 22160 20846 19650 19016 97064 22259 12609 104394 14815 21926 23849 19013 20379 16956 64898 17978 14245 13386 18413 16195 19017 16333 12702 20249 13082 17258 384783 103968 19401 105980076 17259 19015 69050 11770 12703 22227 16000 56458 20850 64899 15361 17261 19116 74551 16367 21887 Circulating monocytes and cardiac macrophages in diastolic dysfunction%WikiPathways_20260410%WP4474%Mus musculus Circulating monocytes and cardiac macrophages in diastolic dysfunction 20296 16153 20750 12772 Complement and coagulation cascades%WikiPathways_20260410%WP449%Mus musculus Complement and coagulation cascades 19123 12259 16644 14058 17174 12258 21788 22371 18792 232345 12946 12269 14069 58992 12509 21824 18815 50908 12266 12628 109828 11905 13136 12267 14962 14061 18787 14066 13137 109821 14068 14067 69379 18793 18816 18791 12263 56373 17194 15139 12274 17175 50909 12260 14071 14062 12268 12630 12273 12061 11537 15160 19128 17221 12902 12262 268591 14060 16621 110135 12279 Elongation of very long chain fatty acids%WikiPathways_20260410%WP4491%Mus musculus Elongation of very long chain fatty acids 14104 68801 12686 54325 74559 170439 83603 54326 56473 170439 68801 76267 12686 30049 20249 20250 329065 56473 54325 74559 76267 IL 2 signaling pathway%WikiPathways_20260410%WP450%Mus musculus IL 2 signaling pathway 16183 20851 16453 12928 22324 20846 12912 23872 17096 11651 21752 12700 23871 19247 14694 12703 20850 230126 18707 13684 12402 20844 16818 16185 16184 110157 12508 15894 56717 27979 16451 14784 26395 20963 12043 17346 18708 12702 15962 74769 16432 26419 14389 20848 12675 19229 16452 22608 18709 14815 18795 19697 18706 16186 56324 18033 18762 26396 64685 14360 16653 26420 17164 26413 72508 30955 12929 20662 26416 15519 26417 16367 56484 15170 20416 384783 Osteoclast signaling%WikiPathways_20260410%WP454%Mus musculus Osteoclast signaling 18383 18591 194352 21943 11433 15977 20544 66290 21934 15975 16416 13038 238377 20750 GPCRs class B secretin like%WikiPathways_20260410%WP456%Mus musculus GPCRs class B secretin like 12311 54598 12921 12922 381853 93896 14652 14527 14602 213527 19228 11517 319229 22354 22355 26364 13733 330814 99633 319387 170757 237175 Inflammatory response pathway%WikiPathways_20260410%WP458%Mus musculus Inflammatory response pathway 12524 21938 16779 15978 21827 22370 16183 16190 16185 16818 16777 16186 16189 12825 21939 12842 16782 12843 12487 21947 21937 14268 12519 16184 226519 22637 16776 21825 16191 16192 Blood clotting cascade%WikiPathways_20260410%WP460%Mus musculus Blood clotting cascade 14058 14061 58992 99571 18815 14071 14070 18792 110135 22371 14067 14060 109821 18816 18791 18788 18787 14069 14068 14161 Lipids measured in liver metastasis from breast cancer%WikiPathways_20260410%WP4627%Mus musculus Lipids measured in liver metastasis from breast cancer 79235 Sphingolipid metabolism integrated pathway %WikiPathways_20260410%WP4690%Mus musculus Sphingolipid metabolism integrated pathway 19012 223753 81535 11886 208449 56632 20397 22234 268656 20698 13244 70750 20773 67260 71949 241447 20597 70059 74442 67916 22239 93898 14559 76893 545975 433323 76893 67260 Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle%WikiPathways_20260410%WP4763%Mus musculus Regulation of Pgc1a expression by a Gsk3b Tfeb signaling axis in skeletal muscle 19017 56637 21425 19017 21425 T cell receptor signaling pathway%WikiPathways_20260410%WP480%Mus musculus T cell receptor signaling pathway 72699 218397 12481 22325 26411 12501 22376 16453 12503 78473 108723 20662 94176 56233 14389 12387 12929 19395 14360 27387 20851 18003 16428 13800 14281 20218 18709 22323 72349 71520 12525 20663 18019 12507 23853 54353 12928 17096 11431 13430 26431 18761 19303 15170 14784 16797 16818 20963 26417 545902 12700 18708 11308 16476 101540 13383 77647 18479 53416 19271 12488 12504 19247 20850 12500 242687 11857 17975 23939 23880 26396 22165 24055 192656 54126 104248 73341 20779 16438 14083 22248 22145 17829 11350 26558 12608 14357 18803 20416 26413 19248 20846 230126 57257 329693 16923 16822 26395 109905 208650 77799 240754 17973 26401 22324 12402 12914 22154 545622 109880 19200 20491 74039 19264 22637 13169 19229 12502 14026 215280 19260 19354 27371 12912 54390 12540 19056 94212 11651 17444 12042 107746 GDNF RET signaling axis%WikiPathways_20260410%WP4820%Mus musculus GDNF RET signaling axis 24063 17300 20671 14048 20666 18504 58198 11609 14234 14573 14462 329628 268902 12159 16869 20563 23892 19713 14585 14634 67042 72938 12387 Peroxiredoxin 2 induced ovarian failure%WikiPathways_20260410%WP4835%Mus musculus Peroxiredoxin 2 induced ovarian failure 12028 13063 13070 15494 12367 20845 21672 Alpha 6 beta 4 integrin signaling pathway%WikiPathways_20260410%WP488%Mus musculus Alpha 6 beta 4 integrin signaling pathway 11848 20166 192897 14360 23844 14083 16403 16785 22352 229933 14784 13518 59079 13866 18708 18709 18710 18706 74769 30955 18707 12821 20416 19882 55948 16772 16777 226519 16776 16779 16773 16774 16780 16782 18479 19353 18810 12476 384783 16367 13649 11835 22062 11350 54401 22627 22629 22631 22612 109620 17295 13685 13684 16418 18208 11651 12367 12015 18750 56717 18753 17393 20779 17126 17127 12575 Mapk signaling pathway%WikiPathways_20260410%WP493%Mus musculus Mapk signaling pathway 21813 19252 17165 13712 170706 26940 19418 12929 216869 110651 26403 16765 218397 12369 320139 381921 22059 16177 12368 13649 11652 21926 13198 12928 69253 15370 14175 12475 11911 14103 65964 13197 21812 19055 12367 68652 18752 26409 56274 12370 109689 19419 14784 269275 16151 109880 26420 20807 26415 53859 26565 26401 19279 18596 26396 21809 19259 16653 19042 16175 12531 14281 18755 78405 12371 17451 16150 15507 11479 11651 53608 19059 50932 12540 110157 50772 23939 26408 18753 18176 18751 26414 11909 26404 13645 18099 16476 26407 225028 26413 71751 21808 193740 18784 216965 26395 63953 18049 19043 17164 14828 67603 30957 319520 224105 26398 225724 240672 19060 109905 19058 26921 17869 66513 15481 21803 13163 18033 26417 233046 17762 26399 18762 103988 18015 23797 19056 19354 12362 12064 18479 26419 16178 18747 26416 22030 26400 19057 215449 29857 22034 18211 26410 17532 16176 20663 235584 114713 14673 12366 19353 17260 26411 18591 23938 14102 192176 17187 16478 Deregulation of renin angiotensin system by SARS CoV infection%WikiPathways_20260410%WP4965%Mus musculus Deregulation of renin angiotensin system by SARS CoV infection 11607 70008 11421 11609 Hypoxia dependent self renewal of myoblasts%WikiPathways_20260410%WP5023%Mus musculus Hypoxia dependent self renewal of myoblasts 15213 15205 15214 17877 17879 17927 12575 18509 17928 18128 56458 15251 22027 Hypoxia dependent proliferation of myoblasts%WikiPathways_20260410%WP5024%Mus musculus Hypoxia dependent proliferation of myoblasts 22339 17700 433766 17927 22084 15234 67731 17877 64930 11651 17127 16000 74747 19744 14164 56717 17126 17928 12310 Hypoxia dependent differentiation of myoblasts%WikiPathways_20260410%WP5025%Mus musculus Hypoxia dependent differentiation of myoblasts 12575 26416 17877 17878 18128 112405 12576 319594 15251 17879 17928 20893 22339 17928 Na K ATPase Src signaling%WikiPathways_20260410%WP5051%Mus musculus Na K ATPase Src signaling 230661 19354 56637 11928 11798 22165 14360 20662 109905 12391 16542 12015 170758 20363 14784 12043 110157 17295 13649 26420 320207 18479 20811 16202 18481 11796 107746 50772 11797 12387 243659 330662 20418 11836 12928 26396 26397 30955 12371 15461 56717 13067 109880 26413 12444 13063 14083 22324 23797 241656 51789 18595 12445 11931 23938 215449 12143 14254 26419 19353 20459 20779 224105 83813 26399 214230 225724 12929 12390 12389 20416 70584 11783 23939 11651 74769 18707 13866 18596 109880 26395 12443 16001 18706 15162 19211 13712 75669 12367 12927 11652 18708 18709 16476 29857 14191 Burn wound healing%WikiPathways_20260410%WP5056%Mus musculus Burn wound healing 22339 18127 16772 12842 21926 15200 21803 18613 73122 18126 14248 11459 14609 56189 216799 Nuclear Receptors%WikiPathways_20260410%WP509%Mus musculus Nuclear Receptors 20182 26379 218772 14815 26424 22026 19411 18227 11835 18667 21907 11819 22337 26423 21834 353187 21833 19885 20183 19883 19015 69050 13865 19016 26563 11614 15370 20181 13983 22260 22259 19401 13982 18171 13864 19013 15378 26380 12355 ID signaling pathway%WikiPathways_20260410%WP512%Mus musculus ID signaling pathway 15901 15902 15903 15904 19645 19651 19650 21423 17927 12566 12428 12447 13712 13714 13713 19185 15205 18507 18504 18510 17877 17878 17928 21406 20787 17681 12156 12168 22339 14254 16542 17125 17128 17129 11910 17127 21815 11482 16818 16001 16000 16367 12387 21752 18033 19697 12161 21947 18049 13645 21416 Fibrin complement receptor 3 signaling pathway%WikiPathways_20260410%WP5128%Mus musculus Fibrin complement receptor 3 signaling pathway 11651 16193 16150 18706 18815 18033 20963 19696 142980 208650 17874 15977 11848 16179 18791 15945 54354 117149 22034 106759 12475 22177 14127 330122 18815 266632 17087 16803 21898 20779 225471 54131 16409 16414 21926 20296 12675 16151 14161 108960 16160 18126 110135 99571 19697 Oxylipins pathways%WikiPathways_20260410%WP5140%Mus musculus Oxylipins pathways 15446 13850 66469 19215 64292 19223 21391 11689 11688 11684 11687 76267 56473 19225 17001 16993 14598 13479 14775 12408 54486 13850 Proteasome degradation%WikiPathways_20260410%WP519%Mus musculus Proteasome degradation 19171 22190 319170 93841 19166 15007 19186 19170 26442 15007 66997 67151 19184 22210 16913 17463 19172 66105 69077 22201 103963 19182 51788 26445 16912 15978 19167 22223 15007 53380 15007 22123 23997 56550 20014 15270 66413 26444 26440 74153 19175 26443 19173 19192 19179 66998 216080 17999 67089 23996 19185 22187 15007 26441 19188 19177 19181 15007 26446 21762 57296 19184 Biogenic amine synthesis%WikiPathways_20260410%WP522%Mus musculus Biogenic amine synthesis 14417 13195 21990 15186 13166 21823 18948 11423 12846 18478 12647 11298 14415 17161 107626 Regulation of actin cytoskeleton%WikiPathways_20260410%WP523%Mus musculus Regulation of actin cytoskeleton 56419 108083 26413 12671 18719 227753 231637 18479 18643 225326 14176 18590 14163 320207 20663 108100 29875 22330 14165 16801 54126 14674 19684 77579 329165 243764 12669 240752 14180 13649 13800 237860 232906 170758 242687 241656 227733 17532 26395 16885 12061 14178 22349 14673 50884 14169 11461 18709 224105 14186 14174 213788 14167 12540 19241 18705 13645 226970 12927 107589 245857 14175 18708 18481 330662 12672 12632 12475 18596 67771 18706 14083 80857 14171 11848 20544 14184 18704 64654 74769 12062 19878 14170 14172 18718 56636 18176 14173 18710 22350 19877 11465 67112 14268 80903 30955 73341 17901 19353 109880 17931 22376 66922 75669 20130 11789 66985 18595 16653 14168 18720 83767 70584 109711 14701 13367 18717 20662 17698 12928 16334 109700 110157 12988 117150 26417 18591 76884 17897 26396 19303 19354 16333 14183 18707 50772 214230 23805 216963 12631 17451 14177 14164 14061 14062 14182 14166 14179 22324 225724 101314 Lac Phe pathway%WikiPathways_20260410%WP5240%Mus musculus Lac Phe pathway 27416 66054 Comprehensive IL 17A signaling%WikiPathways_20260410%WP5242%Mus musculus Comprehensive IL 17A signaling 20302 20311 14268 20304 12540 11459 14825 20315 20303 11475 16000 24099 14118 15511 20613 17345 17220 11522 15289 12842 18591 15132 20656 269437 20311 22059 18749 11749 18792 16176 19225 17392 20846 14219 19353 56717 107589 14701 320011 16193 17218 12367 18590 19325 66870 266692 12266 76709 67089 18793 19697 18938 104184 20583 20309 11848 18481 16176 109828 17387 56378 14432 66922 67771 11927 12282 269823 11600 17395 20310 100503605 15129 13649 19704 230709 18393 19646 12540 19353 18793 56045 12301 22589 18392 18792 18148 50927 18538 19290 98415 18412 67443 12043 17130 17126 56208 20848 66734 17131 225326 17217 17219 17216 21803 17215 56717 20315 17126 17127 11651 20613 20583 21872 16452 Dravet syndrome Scn1a A1783V point mutation model%WikiPathways_20260410%WP5298%Mus musculus Dravet syndrome Scn1a A1783V point mutation model 20265 20501 19049 13823 20511 12298 12297 16832 20512 14580 16828 55936 17161 12295 16542 12286 19417 14810 12287 109731 12294 21926 20912 14802 14660 72821 18706 279653 56716 54393 14415 18033 14400 14396 242425 14811 53623 14402 235281 55943 14645 20910 20266 56717 399548 109270 20269 14799 78757 16490 12322 20265 72446 244059 227743 19094 14168 11651 14417 108069 228960 14394 57138 16524 16519 16513 20525 20503 76257 20527 232333 14395 14397 72961 Globo series sphingolipid metabolism%WikiPathways_20260410%WP5305%Mus musculus Globo series sphingolipid metabolism 14344 227671 93961 26879 Wnt signaling pathway%WikiPathways_20260410%WP539%Mus musculus Wnt signaling pathway 22218 22413 99470 14200 21374 93840 11789 57265 13728 77578 22415 12387 93687 13543 13542 14368 26419 23859 12005 14371 23988 12322 109689 26413 22418 14362 58198 22408 212398 13385 11651 16842 93960 27373 26417 19099 208846 104318 17127 13017 26420 11848 18099 26564 20319 20664 19353 20377 12443 14367 216869 12534 13132 22417 140577 56637 13380 17863 12995 26992 16973 14366 319478 20682 12532 12393 12234 18504 21413 16971 12550 26409 56505 108058 59004 16974 26965 75826 13000 14369 22416 16480 17128 22421 14370 15258 12323 12961 18751 13383 26423 16476 21418 67087 18750 13001 328572 13016 14296 21402 110157 12325 12006 76281 21423 13544 17755 19052 Synthesis and degradation of ketone bodies%WikiPathways_20260410%WP543%Mus musculus Synthesis and degradation of ketone bodies 15356 110446 15360 67041 71911 Exercise induced circadian regulation%WikiPathways_20260410%WP544%Mus musculus Exercise induced circadian regulation 22229 30960 11865 20610 18627 12608 22763 18701 14864 75062 319187 12952 22057 54375 19290 52331 64209 19053 12741 353187 14373 13690 12953 12753 17878 50884 15502 217166 12417 27057 53412 14011 216558 18626 238988 22153 23994 14869 19317 15481 68652 26441 14585 14998 16601 12226 19663 22218 319554 Steroid biosynthesis%WikiPathways_20260410%WP55%Mus musculus Steroid biosynthesis 15497 13074 15493 15496 15492 15495 15494 15486 15487 15485 14060 15488 15490 Calcium regulation in cardiac cells%WikiPathways_20260410%WP553%Mus musculus Calcium regulation in cardiac cells 12295 12325 20191 50779 104110 14702 432530 12322 18751 12290 64337 50778 67972 14678 53313 320707 14613 18797 11549 14696 18821 58175 18749 20190 12326 224129 18768 216869 67865 11550 11554 51791 12292 12672 243764 12288 14615 16500 210044 14609 16439 19085 12289 108058 14695 12286 16519 19737 54401 14697 16521 22631 22629 14611 16438 11941 14620 14621 55948 18760 14701 14682 66066 18753 14708 14623 14679 18754 64214 24012 14773 14709 18767 20192 16440 11514 12669 56470 11548 12315 14225 14618 14616 56533 12372 104111 22627 11749 14672 14707 11515 19734 20541 22630 11513 14687 11556 14622 12317 50782 14699 18762 19084 14693 18769 19736 18755 19088 18761 14704 18750 118454 14688 12373 14681 110893 18821 11938 19735 109689 14683 14619 12287 14677 12671 19739 213788 12323 14612 14706 22628 52163 12297 18752 11512 14772 19087 11555 50780 14617 26385 27222 11931 11936 11932 11933 Eukaryotic transcription initiation%WikiPathways_20260410%WP567%Mus musculus Eukaryotic transcription initiation 235459 24074 13872 68705 229906 23894 67710 102216272 108143 20022 68153 74197 245841 67065 20019 209357 99730 26939 20016 21343 66464 16202 20018 17749 20020 69920 14884 78929 66671 12572 20017 226182 67005 66420 21374 70428 231329 14885 17420 20021 13871 Signal transduction of S1P receptor%WikiPathways_20260410%WP57%Mus musculus Signal transduction of S1P receptor 26417 18705 13610 26413 26934 13609 20698 14677 23939 18797 11652 54447 20598 14678 94226 29857 23797 11651 50772 56632 14679 14739 Monoamine GPCRs%WikiPathways_20260410%WP570%Mus musculus Monoamine GPCRs 15465 11553 15562 13490 15466 12671 11549 13492 15564 13491 11556 11548 243764 15565 15552 12669 15566 12672 13489 213788 11551 15558 15557 13488 15563 11554 11552 15560 15559 15550 11550 15551 11555 FAS pathway and stress induction of HSP regulation%WikiPathways_20260410%WP571%Mus musculus FAS pathway and stress induction of HSP regulation 20740 16175 14084 12369 15507 192656 13368 18479 11783 13163 17164 12370 11545 13347 11857 14103 14082 19645 26419 16476 102626 26398 12368 224105 26409 16906 16907 12371 12633 12043 26401 12367 21926 19090 16905 19249 14102 EGFR1 signaling pathway%WikiPathways_20260410%WP572%Mus musculus EGFR1 signaling pathway 13645 110157 15461 18176 16653 56392 18708 26405 50915 14784 14783 26406 20662 14786 18709 20416 18710 18706 74769 18707 30955 14388 14389 16451 20846 16452 20848 20850 20847 20851 26395 18750 26401 18762 18760 18759 18751 26396 26397 23938 26407 22324 57257 22325 23939 26413 26417 13714 13712 26419 26400 19279 14609 54401 232341 13649 110310 16691 16667 16668 382523 107686 18810 19248 20779 12402 12928 12929 67184 19353 19229 12389 12390 17973 17974 18803 216963 19734 12703 12702 16332 271457 98910 11843 22687 19766 53859 19730 218397 20459 19084 15170 19247 22038 74155 13449 18738 80794 208650 18806 18805 13858 13860 15194 240752 56726 12988 194590 19765 64143 19707 51789 11308 20663 13429 20408 12540 24064 16478 14281 12606 17869 12608 23980 194655 20466 21815 433759 58194 20404 16476 20683 11651 19259 20617 20111 110651 20112 11771 73178 26365 13627 72993 216190 23942 13859 13854 215114 19727 26416 57783 245688 13196 20910 12388 109333 18479 27387 12927 12371 73086 17126 17127 11908 12912 56458 19303 13710 107435 12322 16396 11836 109904 234779 19252 Leptin insulin signaling overlap%WikiPathways_20260410%WP578%Mus musculus Leptin insulin signaling overlap 16452 18607 16847 12702 20848 18710 11651 216233 30955 16337 12703 16333 104418 16846 16367 384783 16369 16370 Integrin mediated cell adhesion%WikiPathways_20260410%WP6%Mus musculus Integrin mediated cell adhesion 16401 73647 109711 16202 14083 16416 16407 20662 22793 109905 16409 12928 16404 16421 12337 381924 20363 19877 16410 16400 22330 107746 16399 12338 19354 19303 214230 26395 12927 192897 320910 18607 12335 20779 330662 57257 109880 12390 16408 11836 268958 23830 16411 109700 14360 26414 12988 12391 212541 15461 23939 12389 16420 50772 20416 16412 12334 23797 26396 18709 104099 21961 12339 16402 213119 110157 22325 12540 23938 12336 16414 224105 26397 26413 20411 215449 26399 18481 16398 11652 12333 19353 19878 26431 22323 16403 18479 11651 14784 16419 241226 319480 54126 228785 70584 225724 29857 170758 21894 20418 miR 1 in cardiac development%WikiPathways_20260410%WP608%Mus musculus miR 1 in cardiac development 16508 54352 15111 Pentose phosphate pathway%WikiPathways_20260410%WP63%Mus musculus Pentose phosphate pathway 14381 66171 66646 21351 19895 21881 110208 Insulin signaling%WikiPathways_20260410%WP65%Mus musculus Insulin signaling 18710 210789 16369 16568 14252 20111 20913 20910 26414 19354 19246 110651 26408 11652 72508 26406 56458 20911 12402 13712 15461 13684 12702 13660 26419 19268 26412 104215 14281 22433 26396 19211 50932 20418 20912 16370 11845 26405 23921 26420 22084 110157 26397 18709 14251 73086 18642 18753 18704 16890 13685 53859 19159 20662 18751 225724 50915 26415 23938 16573 16476 14936 17913 107746 19353 19094 18707 50772 56637 14784 14388 18755 26417 170755 108079 18708 80794 58988 232493 75669 20909 27219 26921 56717 20614 399510 16332 23939 18761 208650 12703 14783 26407 11840 26409 26399 233071 22318 16367 26413 20416 12928 269180 26401 19341 16150 269881 225326 30955 259300 64930 20112 216148 18607 18706 11651 26400 80837 12331 29857 53608 18705 26395 67071 18759 19247 56437 71751 18762 74769 225028 338372 19744 19047 434233 26404 20807 56484 20619 20663 56613 18750 26398 18641 27357 20411 105787 26410 20393 228775 26403 26416 26411 13653 18605 16001 16337 20525 20528 Amino acid metabolism%WikiPathways_20260410%WP662%Mus musculus Amino acid metabolism 14782 15186 12411 20603 17449 14860 18746 11898 11754 107508 13382 18534 14661 15360 140483 13195 11364 14719 11992 27273 19125 78920 14085 74147 15109 105148 11668 320092 227095 234724 69719 212679 12116 12035 113868 58875 108682 18452 18597 22018 14630 11532 18242 242083 26876 17161 21823 231691 102436 14378 22375 16828 11522 14660 66945 23874 27053 18597 110695 246221 56451 15356 11529 18563 209027 18293 109900 14854 14194 107869 21990 17850 11846 17448 15926 18948 13166 11429 14645 104458 72039 18263 14317 56454 14718 12974 104112 22321 27402 56720 18416 66925 68738 227231 20810 15107 11847 Leptin and adiponectin%WikiPathways_20260410%WP683%Mus musculus Leptin and adiponectin 72674 105787 19079 16846 68465 107476 19082 16847 12894 11450 Wnt signaling pathway and pluripotency%WikiPathways_20260410%WP723%Mus musculus Wnt signaling pathway and pluripotency 22059 71978 18761 13543 73699 14362 22418 16974 269643 18751 22411 14369 13017 19053 19052 12914 13542 14366 21415 93735 14283 52432 14370 21413 26409 56637 14296 13016 22410 71887 17869 16835 22419 12387 22408 22411 22422 22416 12444 13544 17393 26420 22421 18044 18750 22414 16842 26931 72293 21410 14365 20674 18792 18755 18760 22413 30050 18472 19015 69050 18099 51792 21405 18752 18762 14368 57265 72930 12006 12445 14367 22417 71950 11789 26932 16476 328572 22412 16973 12388 22420 26414 18753 110854 18999 12443 12005 26934 22409 27373 22415 56805 93960 18754 14371 18759 15221 11848 12505 Glutathione and one carbon metabolism%WikiPathways_20260410%WP730%Mus musculus Glutathione and one carbon metabolism 16790 14381 23887 14775 12116 13433 210009 17769 14630 14782 14598 14854 14629 434437 74340 238505 108645 13435 218865 14598 14776 13436 11720 75475 15926 269378 20425 14778 108037 625249 12411 107869 Tryptophan metabolism%WikiPathways_20260410%WP79%Mus musculus Tryptophan metabolism 64385 70790 15930 13106 57751 270076 56752 15469 11669 19378 107626 13076 17246 18293 109731 11671 13195 15108 12359 22215 15107 13123 23923 110446 70789 71562 13078 11298 11761 74754 266645 13077 72082 22375 21743 13075 11668 320092 13110 107766 76507 93747 56720 13107 21990 Focal adhesion%WikiPathways_20260410%WP85%Mus musculus Focal adhesion 12826 230661 11465 18607 19354 56637 107589 53867 21828 22165 14360 20662 12831 16420 105083 109905 12391 12015 319480 170758 12815 16780 20363 14784 329278 12043 110157 227377 12333 15234 17295 13649 11848 16404 16409 12843 26420 320207 15891 18479 12832 20811 16202 94216 228785 18481 21827 16398 11796 16773 107746 18717 12824 12829 50772 13645 192897 16402 11797 16775 320910 381924 16416 19878 16776 243659 330662 12643 20418 213119 11836 12928 26396 26397 81877 170736 30955 16400 12842 16403 14205 109880 192176 26413 12444 71785 13367 17931 16410 14083 22330 16772 22371 12825 22324 23797 16411 241656 51789 16414 18595 12445 54635 23938 16399 215449 12143 14254 26419 19353 23928 19877 20459 21826 12540 16421 22793 20779 224105 18591 83813 20750 26399 214230 225724 12929 14268 11855 12814 16401 12390 12389 22370 16000 20416 109711 18654 70584 11852 18590 23939 11651 19303 74769 18707 13866 18596 109880 26395 226519 12443 16779 22340 21894 18706 16774 15162 19211 22341 16777 13712 19699 75669 12827 11461 16412 241226 16407 104099 22339 12834 16419 21825 16408 12927 11652 18708 18709 16782 22323 21923 17904 16476 29857 14191 21960 Toll like receptor signaling%WikiPathways_20260410%WP88%Mus musculus Toll like receptor signaling 24088 21898 117149 142980 17153 73914 266632 225471 17874 16179 19765 106759 108960 14082 22031 12367 12370 56489 11308 54131 56480 22026 26416 12675 68652 19106 22034 26399 16150 17121 16151 18033 18034 IL 4 signaling pathway%WikiPathways_20260410%WP93%Mus musculus IL 4 signaling pathway 18762 11651 18033 56468 16190 20852 18708 19094 72508 15170 16451 13712 26413 13449 19247 16453 17969 16818 20662 20850 15361 384783 20416 14083 14159 14360 16189 54721 16367 18707 218397 26417 26416 16164 20844 18753 12767 12914 20846 18759 12702 12015 16452 114774 20375 320129 328572 23871 75292 20779 18803 16331 11909 14784 12703 16186 18706 18709 19697 12402 12048}