GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis HSD11B1 HSD11B2 SRD5A2 CYP11B2 CYP21A2 AKR1C1 AKR1C2 AKR1C4 CYP3A4 BENZENE METABOLISM%WIKIPATHWAYS_20260410%WP3891%HOMO SAPIENS Benzene metabolism NQO1 GSTM1 EPHX1 DHDH CYP2E1 MPO MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260410%WP5241%HOMO SAPIENS Mitochondrial beta oxidation ECHS1 ACADL EHHADH ACSL3 HSD17B10 ACADSB DECR1 MAPK CASCADE%WIKIPATHWAYS_20260410%WP422%HOMO SAPIENS MAPK cascade ARAF NRAS RRAS MAP2 MAPK1 MBP HRAS MAP2K6 MAPK3 MAP3K2 MAP2K3 MAP2K4 JUN MAP2K1 MAP3K1 MAP2K2 BRAF MAPK14 MAPK12 MAPK10 PLCB3 RASA3 GRB2 KRAS SOS1 RAF1 LAMTOR3 SOS2 SIPA1 MAP3K12 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260410%WP585%HOMO SAPIENS Interferon type I signaling CRK IRF9 IFNAR1 MAPKAP1 PIK3R2 PIK3R1 CBL SOCS3 RAP1A SOCS1 EIF4EBP1 STAT4 FYN EIF4E EIF4B STAT1 STAT2 STAT3 PTPN11 MTOR PTPRC RPS6KB1 REL PTPN6 MAP2K6 MAP2K3 MAP3K1 MAPK14 EIF4A1 IRS1 PIK3CD CRKL RPTOR RPS6KA4 RPS6KA5 MLST8 RAC1 JAK1 IFNAR2 PRMT1 RPS6 TYK2 GAB2 VAV1 PIAS1 ZAP70 CREB1 LCK RAPGEF1 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260410%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle IDH3B OGDH SUCLG2 SUCLG1 ACO2 DLD FH MDH2 SDHC SDHD SDHA SDHB CS SUCLA2 FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260410%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins IL1A TNFSF6 MAPKAPK3 NFX1 MAPKAPK2 BCL2 FAS CYCS SMIM40 MAP2K4 JUN MAP3K1 RB1 PRKDC FAF1 TNF LMNB2 ACTG1 CASP9 MAPK8 PAK1 CASP8 CASP6 PS1TP5BP1 CASP10 CASP3 ARHGDIB LMNA FADD MAP3K7 SPTAN1 HEL-S-102 DFFB DFFA PARP1 APAF1 RIPK2 ACTA1 ATR SIGNALING%WIKIPATHWAYS_20260410%WP3875%HOMO SAPIENS ATR signaling ATRIP ATR RAD9A RPA3 CHEK1 RPA1 HUS1 RAD1 TOPBP1 RAD9B MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260410%WP4318%HOMO SAPIENS Mitochondrial fission and fusion FIS1 OPA1 MTFP1 BNIP3 MFN1 BAX MFN2 SH3GL2 BCL2L1 MIB1 APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260410%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 MAPK10 CASP2 TNFSF6 RIPK1 FAS CYCS CASP9 CASP8 CASP6 CASP3 FADD MAP3K1 APAF1 NFKB1 TNFRSF1A AIFM1 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260410%WP4842%HOMO SAPIENS Mammalian disorder of sexual development EMX2 RBFOX2 AMHR2 DMRT1 DHH CBX2 FST GATA4 FOXL2 PBX1 NR5A1 MAPK11 FGF9 WT1 CTNNB1 SOX8 SOX9 SRY RSPO1 INSL3 AMH FGFR2 WNT4 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260410%WP4297%HOMO SAPIENS Thiamine metabolic pathways OGDH BCKDK PDHA1 TPK1 HEL107 SLC19A3 DKFZp667O1614 SLC19A2 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260410%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway MTMR1 PI4K2B MTMR2 PTEN MTMR8 PIK3C2G PIK3C2A STM7 MTMR6 PIK3C2B MTM1 PIP4P2 PIP4P1 INPP5D INPP5E PLCG2 PIP4K2A PIP5K1A PLCE1 PIP4K2B PLCG1 PIP5K1C TPTE2 SACM1L IPMK OCRL FIG4 INPP4A INPP4B PIKFYVE PLCB4 PIK3CA PI4KB PLCB3 PLCD3 PLCB1 PLCB2 PLCD4 PI4K2A PIK3CD METHYLATION PATHWAYS%WIKIPATHWAYS_20260410%WP704%HOMO SAPIENS Methylation pathways PNMT NNMT TPMT MAT1A INMT HEDGEHOG SIGNALING%WIKIPATHWAYS_20260410%WP47%HOMO SAPIENS Hedgehog signaling ADRBK1 PTCH2 IHH SAP18 KIF7 GLI3 DHH SHH SMO SIN3A SUFU PTCH1 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation BMP2 RBL1 FGF18 SNAI1 FGFR3 STAT1 MAPK1 MAPK3 MAP2K1 MAP2K2 MAPK14 MAPK12 RAF1 MAPK11 FGF9 IHH SOX9 CDKN1A CNP THRA NPR2 PTH1R PTHLH PPP2CA ATG5 MAPK13 BMP4 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260410%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress NQO1 IL1A PTEN ATF2 BCL2 CXCL8 KEAP1 NRF1 PTGS2 FOXO1 CHEK1 IKBKB HMOX1 IKBKG MAP3K5 GSX1 NOS2 TSC1 ATR FOS IPCEF1 MTOR SIRT1 PINK1 IL6 MAP2K3 RHEB MAP2K4 CCNE1 PIP CDK2 MDM2 BCL2L1 NFE2L2 NFKB1 MAPK14 PIK3CA TNF MAPK8 RPS6KA5 CDKN1A CREB1 WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260410%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials CTNNB1 LRP6 PORCN CREBBP LRP5 HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation MXI1 NCKAP1L NFE2 RIOK3 NFATC2 XB MHC2TA FLI1 ARHH KLF1 GP9 IL3 KITLG IL5 FOSB IL1A FOS IL6 CSF3 CSF2 SPI1 TRAF3IP3 CSF1 EPO ITGB3 ITGA2B IKZF1 LYL1 HMGN5 TRIM29 MYB PIM1 CD34 HES6 LMO2 CBFA2T3 RUNX1 IL1B ZNF835 NOTCH1 LEF1 CXCR4 GATA2 VAV1 ACVR1B GATA1 ABO NR1A2 TPO MUC1 UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260410%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts UGDH UXS1 GFPT1 PGM3 GCK HK2 HK3 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260410%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte BMP7 BMP2 LEP ZIC1 PRDM16 DKFZp781O1323 PPARG HOXC9 ZNF423 PPARGC1A HOXC8 PPARGC1B MPZL2 CEBPA SMAD1 DGIC CEBPB CEBPG HSPB7 CIDEA SMAD9 EBF3 SLC7A10 BMP4 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260410%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells PPM2C HEL-S-30 HEL-S-133P PFKP TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260410%WP3851%HOMO SAPIENS TLR4 signaling and tolerance TLR4 MYD88 CXCL8 IKBKB INPP5D IKBKG IL6 NFKB1 RIPK1 TNF TRAM1 TBK1 IRAK1 IKBKE CHUK IFNB1 IRAK3 MAP3K7 IRAK4 TICAM1 TIRAP NFKBIA MAP3K7IP1 IRF3 TRAF3 TRAF6 IRF7 FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260410%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes SCARB1 SLC27A1 PCSK9 DBI LIPA APOE APOB LDLR ACSL3 ABCA1 MYLIP STARD3 ACSL1 SORT1 ACSL6 ACSL5 APOA4 FABP1 FABP2 FABP4 SOAT1 STAR SOAT2 NPC2 APOC2 APOC1 SLC27A3 LPA SLC27A2 SLC27A4 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260410%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome RAD50 PAXIP1 RAD21 MRE11A ATM BRCA1 NBN SMC3 SMC1A RAD18 MDC1 ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260410%WP2374%HOMO SAPIENS Oncostatin M signaling PIK3R1 SOCS3 STAT1 STAT3 PTPN11 MTOR CEBPB MAPK8 CASP3 NFKBIA MAPK1 FOS HRAS MAPK3 MAP2K1 CDK2 MAP2K2 NFKB1 MAPK14 GRB2 KRAS SOS1 RAF1 CDKN1B JAK3 IRS1 JUNB PRKCH PRKCB PRKCE PRKCA OSMR IL6ST SRC JAK1 PXN HIF1A RELA RPS6 MAPK9 TYK2 PTK2B RICTOR EGR1 STAT5B JUND CREB1 OSM VEGFA INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260410%WP1971%HOMO SAPIENS Integrated cancer pathway BLM BACH1 BBC3 PTEN CHEK2 MYC SMAD2 BCL2 BARD1 CDKN2B POU2F1 BAD CHEK1 PLK1 CDC2 CDC25B MSH6 MAP3K5 MSH2 STAT1 CDK4 NOXA1 ATR BAX CDK2 MDM2 RAD50 MRE11A ATM BRCA1 RB1 CDKN1B CASP9 CASP8 CASP3 JAK1 CDKN1A ATF1 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260410%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis PPARGC1A LDLR ABCA1 PRKAA1 HMGCS1 NR1H3 MTOR NR1C1 SIRT1 SIRT6 HMGCR MED15 SREBF2 SCD FASN 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome TUBGCP4 NIPA2 CYFIP1 FMR1 TUBGCP5 NIPA1 TUBGCP6 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260410%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling PIK3R2 PIK3R1 RAP1A STAT1 CDK4 STAT3 MTOR RPS6KB1 PIK3CA IGF1R PLCB1 CCND3 RPS6KA1 TSHB RB1 PDPK1 PDE4D SCRIB RBL2 GNAI3 ADCY3 GNAI1 RAP1GAP MYL12B GNA13 GNG2 CGA KCNIP3 TSHR GNAO1 APEX1 GNB1 GNAS MAPK1 HRAS MAP2K6 MAPK3 MAP2K3 CCNE1 MAP2K1 CDK2 BRAF MAPK14 RAF1 CDKN1B SRC JAK1 RPS6 CREB1 HEME BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP561%HOMO SAPIENS Heme biosynthesis ALAS2 ALAS1 FECH UROD UROS HMBS CPOX ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260410%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD LPL NQO1 AHR EGFR PLAGL1 MYC CYP1B1 EP300 CCL1 CD36 FGF21 PTGS2 AIP NCOR2 KLF6 GCLC CDC37 NRAS NF1 CYP1A1 AHRR MAPK1 NCOA7 HRAS MAP2K1 CDK2 NFE2L2 NFKB1 KRAS RB1 RAF1 TNF CDKN1B SRC CDKN1A RELA VEGFA RET STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260410%WP383%HOMO SAPIENS Striated muscle contraction pathway MYOM1 HEL113 HEL-S-273 TTN TNNI1 TNNI2 TNNI3 DMD HEL-S-108 MYBPC3 TMOD1 ACTN2 TPM3 TNNC1 TPM1 TNNC2 ACTN4 ACTA2 MYL4 MYL1 TNNT1 MYL2 MYL3 TNNT3 MYH8 ACTG1 TCAP MYH6 tmp_locus_29 ACTA1 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260410%WP5193%HOMO SAPIENS Cholesterol synthesis disorders IDI1 FDPS MVK HSD3B2 HMGCS1 CYP51A1 DHCR24 MSMO1 SQLE HMGCR EBP PMVK SC5D MVD DHCR7 LBR FDFT1 AGE RAGE PATHWAY%WIKIPATHWAYS_20260410%WP2324%HOMO SAPIENS AGE RAGE pathway MMP2 MMP9 DDOST MMP14 EZR ROCK1 SMAD2 FOXO4 AGER PRKCZ INS CDC42 MSR1 INSR INHBB HEL-S-44 STAT1 ARHA SP1 STAT3 ALPL CASP9 MAPK8 CASP8 CASP3 CHUK IRAK4 TIRAP NFKBIA MYD88 EGFR ATF2 CYCS FOXO1 IKBKB NOS2 MAPK1 MAPK3 JUN MAP2K1 NFKB1 MAPK14 RAF1 IRS1 PRKCB PRKCA RAC1 SRC HIF1A RELA MAPK9 STAT5B NCF1 HEL70 MMP7 MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260410%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 STAT3 MMP9 CHI3L1 IL6ST MYC SOCS3 BAX STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP496%HOMO SAPIENS Steroid biosynthesis HSD3B2 HSD17B1 HSD17B2 HSD3B1 HSD17B3 HSD17B4 F13B HSD17B7 CYP17A1 CPN1 SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260410%WP4496%HOMO SAPIENS Signal transduction through IL1R IL1A MYD88 IKBKB MAP2K6 IL6 MAP2K3 JUN MAP3K1 IL1RN IFNA1 NFKB1 ECSIT MAPK14 IRAK2 TGFB1 IL1R1 MAP3K14 TNF MAPK8 IRAK1 CHUK IL1B IFNB1 RELA IRAK3 MAP3K7 NFKBIA MAP3K7IP1 TRAF6 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260410%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway GGPS1 IDI2 ACAT2 ACAT1 HMGCL IDI1 FDPS MVK HMGCS1 HMGCR PMVK MVD FDFT1 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260410%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling BCL2 BAD FOXO1 IKBKG MAPK1 MTOR MAP2K1 MDM2 MAP2K2 NFKB1 CREBBP PIK3CA GRB2 KRAS SOS1 RAF1 GSK3B PDGFA CDKN1B KLK3 CCND1 CASP9 AKT3 CTNNB1 CDKN1A NFKBIA KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260410%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary MMP9 NRAS MAPK1 HRAS MAPK3 HSD3B1 STAR MAP2K1 MAP2K2 NFKB1 PLCB4 PIK3CA PLCB3 PLCB1 PLCB2 KRAS RAF1 PIK3CD ARRB2 PRKCH BMP15 PRKCB CYP11A1 PRKCE KISS1R PRKCA KISS1 GDF9 FSHR PRKCQ AMH EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260410%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells TGFB1 ERBB2 MFGE8 EGFR MET CD133 KRAS SMAD2 RAF1 NRAS CTNNB1 MTOR HRAS SMAD4 WNT3A HGF AXIN1 TGFA TGFBR1 TGFBR2 DKK4 TGFBR3 TSPAN8 APC LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260410%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer CDK8 HNRNPK CDK6 NOTUM MYC TCF3 CSNK1A1L EZH2 CCND3 GSK3B CCND1 WNT3A MAP3K7 AXIN1 DKK4 APC WNT2B CHD8 FZD10 FRAT1 FRAT2 CCND2 SOX17 RUVBL1 SOST CER1 APC2 WNT5B CSNK2A1 CSNK2A3 CSNK2A2 CTNNBIP1 KREMEN1 CSNK1E AXIN2 WNT16 SENP2 DKK1 JUN DKK2 SFRP4 SFRP1 SFRP5 PORCN CSNK2B ROR1 LRP5 ROR2 LRP6 ATF3 CTBP2 CTBP1 MACROH2A2 NLK CXXC4 NKD1 NKD2 WIF1 DVL1 DVL2 DVL3 WNT1 WNT3 FZD1 TFAP2A CTNNB1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 LEF1 FZD5 WNT4 CSNK1A1 RYK WNT7B FZD7 FZD9 WNT7A FZD8 FOSL1 EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260410%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system EIF5A XPO4 IGF2BP1 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260410%WP5087%HOMO SAPIENS Pleural mesothelioma NOTUM PTEN CSNK1A1L EZH2 SPARC RPS6KA3 RASSF1 RASSF2 RASSF3 RASSF4 RASSF6 KDR LGALS9 BTRC PRKAB2 FLT3LG PRKAB1 HCFC1 BTC DDIT3 ULK2 ULK1 IDO1 EPHA2 TERT PLCB4 PDGFD PIK3CA PDGFC STK38L WWTR1 NGFR PHC1 SETDB1 IGF2 RASSF7 IGF1 BAP1 SETD5 SETD2 PRKAG1 PRKAG2 LIMD1 BMI1 AREG PRSS23 PRKAG3 FGF8A TEAD2 GABPA CDKN1A TEAD3 TEAD4 MAP4K1 IL10 MAP4K2 MINK1 KIF23 FGF7B CIT SLC7A5 FGF7A KIT CD47 FGF18 PIGF VGLL4 FGFR3 ATF2 CD44 HBEGF YAP1 FGF6B NTF4 NTF3 FOXO1 CTNNA1 PAK6 CTNNA3 CTNNA2 MAP3K5 MEF2D MAP4K3 PAK4 TSC1 SUZ12 CDKN2A IL34 VEGFB FGF5C IL6 VEGFC RHEB VEGFD CCNE1 MAD2L1 WWC1 CDK2 CDH9 MDM2 FGF2 ACTG2 PORCN CDH8 CTGF LRP5 AMOT LRP6 CSF3 CDH6 CSF2 YY1 CDH4 FGF7 CSF1 FGF8 DEPTOR CDH2 ITGB3 MAP3K6 HMGN1 PDGFRA TSC2 COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 TNIK AJUBA IL1B MAD1L1 DSC3 CSF1R MAX LEF1 KMT2C EFNA5 EFNA4 BAG2 FGF20 CDH24 NLRP3 FGF23 MAP2K5 FGF22 MCL1 BDNF SELE EFNA1 MOB1A EFNA3 CDK7 LIN28B FGF14 CXCL12 KITLG EFNA2 MAP3K10 MDM4 NF2 FGFR4 FGF13 FGF12 OGT MCU MAP3K11 EIF4G1 FGF10 FGFR1 ITGB1 FLT1 ITGB4 FLT3 HEL-S-31 FLT4 LAMC2 CXCL1 HMGB1 LAMC1 FOXM1 CXCL5 PRB1 MDK RB1CC1 PPARGC1A PRB2 WDR5 HEL-S-1 ITGAV ITGA4 EED ITGA2 MMP3 ITGA1 TRAF2 NGF TTI1 LATS1 LATS2 CDH10 CDH11 AKT1S1 CDH12 ITGA6 CDH15 CDH16 CDH17 CDH18 CDH19 LAMA5 PRKAA2 LAMA1 UHRF1 LAMA4 LAMA3 SLC3A2 RNF2 MAPK7 RBBP4 CCL5 CCL4 CCL2 BAK1 CTHRC1 NTRK1 NTRK2 ANGPT4 MOBKL1A ANGPT2 FABP4 LAMB3 ANGPT1 EGF LAMB2 LAMB1 ASXL1 RPS6KB2 ATM BRCA1 SRC HIF1A MAPK9 VEGFA BBC3 MYC BARD1 CDK4 PRKAA1 IGF1R CCND3 RPS6KA1 EGFR FGF21 MAPK1 HRAS MAP2K6 MAPK3 MAP3K2 MAP2K3 MAP2K4 JUN MAP2K1 MAP3K1 MAP2K2 MAPK14 MAPK10 GRB2 ACTA2 SOS1 TNNT1 RAF1 PIK3CD RPTOR RPS6KA5 MLST8 JAK1 RPS6 CREB1 MMP2 MMP9 MMP14 AGER INS EIF4EBP1 INSR EIF4B STAT1 SP1 MTOR RPS6KB1 TGFB1 GSK3B PDGFA ACTG1 CCND1 AKT3 MAPK8 PAK1 PS1TP5BP1 WNT3A HGF AXIN1 TGFA DKK4 ACTA1 APC MET MAPKAPK2 WNT2B BCL2 CHD8 FZD10 FRAT1 CYCS FRAT2 CCND2 SOX17 SOST CER1 WNT5B CSNK2A1 CSNK2A3 CSNK2A2 KREMEN1 CSNK1E WNT16 SENP2 BAX DKK1 DKK2 SFRP4 SFRP1 SFRP5 NFKB1 CSNK2B ROR1 ROR2 ATF3 CTBP2 CTBP1 CXXC4 WIF1 DVL1 DVL2 DVL3 WNT1 FGF9 WNT3 FZD1 CTNNB1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 FZD5 FGFR2 CSNK1A1 WNT4 RYK WNT7B FZD7 FZD9 WNT7A FZD8 FOSL1 OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260410%WP3287%HOMO SAPIENS Overview of nanoparticle effects CCND3 LAMA3 BCL2 CXCL8 PTGS2 TNF AKT3 HMOX1 PIK3CD COL4A1 IL6 BAX CRP PTGS1 NFRKB WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP4149%HOMO SAPIENS White fat cell differentiation INS FOXO1 CTNNA1 NR1H3 CEBPA CEBPB DDIT3 CEBPD RORA GATA3 NR3C1 EVI1 TLE3 EGR2 NR2F2 PPARG KLF4 ZNF423 KLF15 KLF2 KLF5 IRF4 RARA WNT10B TCF7L1 GATA2 STAT5B IRF3 CREB1 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5275%HOMO SAPIENS Ether lipid biosynthesis PEX16 PEX19 LPCAT1 PEDS1 ALDH3A2 UGT8 GNPAT PEX7 PEX5L PEX3 DHRS7B AGMO AGPS FAR1 CEPT1 LPIN1 LPIN2 ACAD10 LPIN3 STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260410%WP4463%HOMO SAPIENS Steroidogenic pathway HSD17B1 HSD3B1 STAR CYP17A1 CYP11A1 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260410%WP696%HOMO SAPIENS Benzo a pyrene metabolism EPHX1 CYP1B1 AKR1C1 AKR1C2 AKR1C4 HEL-S-165mP CYP1A1 CYP3A4 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260410%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing RNASEH2C RNASEL RNASEH2B RNASEH2A TREX1 RNASET2 CGAS ADAR MITA IFIH1 MAVS OAS1 RIGI IFNB1 IRF3 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260410%WP3929%HOMO SAPIENS Chemokine signaling CXCL13 CXCL14 CXCL16 PREX1 PRKACG FOXO3A TIAM1 ADCY9 PARD3 ELMO1 SHC4 SHC2 SHC3 PIK3R3 IL8RB PIK3R5 GRK1 GNG10 PLCB4 GRK5 PIK3CA GRK4 CCR10 LYN PLCB1 CCR1 PLCB2 XCR1 PPBP GNG12 GNG11 GNG13 CXCL11 GNB2 GNAI3 GNB4 ADCY3 GNB3 GNAI1 GNB5 NFKBIB ITK CXCL9 GNG2 ADRBK1 WASL CXCL3 CX3CL1 GNGT1 GNGT2 GNB1 CCR8 CCR7 CCR6 CCR4 CCR3 CCR2 VAV3 VAV2 XCL1 DOCK2 CX3CR1 CCL11 ROCK2 CXCR5 WAS PRKX ADCY1 CCL1 CXCR6 ADCY8 ADCY6 GNG3 IKBKB CCL7 GNG5 IKBKG GNG4 NRAS CXCR3 GNG7 CCL3 MAPK1 GNG8 CSK HRAS CCL19 CCL17 MAPK3 CCL15 CCL25 CCL24 CCL22 CCL21 MAP2K1 CCL20 c-fgr CCL28 BRAF CCL27 PF4 CCL26 PLCB3 GRB2 KRAS SOS1 RAF1 SOS2 PIK3CD CRKL RAC1 CXCR4 VAV1 NCF1 CRK PIK3R2 PIK3R1 ROCK1 PRKCZ RAP1A CDC42 CXCL12 STAT1 STAT2 STAT3 CXCL5 GSK3B AKT3 ARRB2 PAK1 CHUK NFKBIA CCL5 CCL4 NFKB1 JAK3 PRKCB PXN RELA PTK2B STAT5B CANCER PATHWAYS%WIKIPATHWAYS_20260410%WP5434%HOMO SAPIENS Cancer pathways VHL CAMK2G HES5 PTEN LAMB4 EPOR PLCG2 PLCG1 PLCB4 PIK3CA PLCB1 PLCB2 SHH SMO SUFU PTCH1 PTCH2 KIF7 GLI3 CDKN1A BMP4 BMP2 FGFR3 CXCL8 KEAP1 PTGS2 FOXO1 IKBKB HMOX1 IKBKG NOS2 FOS IL6 CCNE1 CDK2 MDM2 NFE2L2 CREBBP LRP5 LRP6 SPI1 EPO ITGA2B PIM1 RUNX1 NOTCH1 LEF1 CXCR4 IL3 KITLG IL5 CEBPA PPARG CHUK NFKBIA TRAF3 TRAF6 CDKN1B JAK3 PRKCB PRKCA IL6ST HIF1A RELA MAPK9 STAT5B VEGFA BBC3 MYC SMAD2 CDKN2B BAD MSH6 MSH2 CDK4 IGF1R CCND3 GNAI3 ADCY3 GNAI1 GNA13 GNG2 GNB1 GNAS RET EGFR EP300 TPM3 MMP2 ROCK1 ARHA SP1 IFNA1 TGFB1 GSK3B PDGFA KLK3 CCND1 AKT3 SMAD4 WNT3A HGF AXIN1 TGFA TGFBR1 TGFBR2 APC ERBB2 MET WNT2B FZD10 FRAT1 FRAT2 CCND2 APC2 WNT5B AXIN2 WNT16 CTBP2 CTBP1 DVL1 DVL2 DVL3 WNT1 WNT3 FZD1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 FZD5 WNT7B FZD7 FZD9 WNT7A FZD8 CDK6 RASSF1 FLT3LG TERT IGF2 IGF1 KIT CTNNA1 CTNNA3 CTNNA2 CDKN2A VEGFB VEGFC VEGFD PDGFRA COL4A2 COL4A1 COL4A4 COL4A3 COL4A6 COL4A5 CSF1R MAX CXCL12 FGFR4 FGFR1 ITGB1 FLT3 FLT4 LAMC2 LAMC1 ITGAV ITGA2 MMP3 TRAF2 ITGA6 LAMA5 LAMA1 LAMA4 LAMA3 BAK1 NTRK1 LAMB3 EGF LAMB2 LAMB1 RPS6KB2 EVI1 RARA PRKACG ADCY9 PIK3R3 GNG10 GNG12 GNG11 GNG13 GNB2 GNB4 GNB3 GNB5 GNGT1 GNGT2 NQO1 GSTM1 ROCK2 ADCY1 ADCY8 ADCY6 GNG3 GNG5 ARAF GNG4 NRAS GNG7 MAPK1 GNG8 HRAS MAPK3 JUN MAP2K1 MAP2K2 BRAF HEL-S-125m MAPK10 TFG PLCB3 KPG_010 DAPK2 GRB2 BCR KRAS EML4 SOS1 AGTR1 RAF1 JAG2 GSTM4 SOS2 GSTM3 GSTM2 JUP FZD4 IF1AA9 PIK3CD GSTM5 CRKL HEY2 ELOC APPL1 RPS6KA5 IFNGR1 IFNGR2 RAC1 JAK1 WNT9B WNT9A IFNAR2 F2 DDB2 PAX8 RARB WNT8A WNT8B IL12RB1 RUNX1T1 EGLN1 EGLN3 EGLN2 CRK CCDC6 CSF3R IFNAR1 IL5RA PIM2 PIK3R2 IL13RA1 PIK3R1 IFNA13 CBL IFNA14 IFNA16 IFNA17 F2R STAT4 RBX1 MSH3 IFNA10 NOTCH2 STAT1 NOTCH3 STAT2 GSTT2 STAT3 KNG1 BCL2L11 TPR MTOR IFNA21 ZBTB16 RPS6KB1 NFKB2 ALK FH HSP90AB1 NKX3-1 PLEKHG5 TRAF1 TRAF4 TRAF5 IL3RA BIRC5 CCDC42 BIRC7 BIRC2 BIRC3 HDAC2 HDAC1 RB1 IL2RG E2F2 E2F3 TXNRD3 TXNRD2 PML RAD51 CASP9 IL2RA MAPK8 IL2RB CALML6 CASP8 HHIP CALML3 CALML4 EDNRA CASP3 EDNRB IL12B IL12A FADD SKP2 SKP1 IL15RA IL23A MGST3 LPAR1 APAF1 MGST1 MGST2 LPAR2 LPAR3 TNFSF6 LPAR4 GSTT2B GADD45B GADD45A BCL2 GADD45G IFNA4 FAS IFNA7 CYCS IFNA6 IFNA2 BRCA2 IFNA8 RAC3 NCOA1 EDN1 IL15 IL13 ARHGEF1 PTGER4 PTGER1 PTGER2 PTGER3 RXRB RXRA RXRG BAX ARNT2 GSTA5 BCL2L1 GSTA4 GSTA3 NFKB1 F2RL3 IL6R RALBP1 NR3A2 CCNE2 CSF2RB CSF2RA RASGRP4 PLD2 RASGRP3 PMAIP1 IL2 IL4 IL7 IL7R NR1C2 CKS1B BDKRB2 BDKRB1 CTNNB1 POLK ARHGEF11 ARHGEF12 HEL-S-21 DCC HEL-S-22 CCNA2 FGFR2 IFNG WNT4 RALA CAMK2D RALB CAMK2A DLL3 DLL4 GNA11 HES1 COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260410%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CSF3 TMPRSS2 CXCL8 ACE2 IL2 TNF IL7 CCL2 IL2RA CCL3 IL1B IL6 IL10 RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260410%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis MLST8 FOXO3A EGFR MAPKAP1 PTEN MTOR RPL11 RIOK2 RICTOR RIOK1 AKT3 PIK3CA MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260410%WP2003%HOMO SAPIENS miR targeted genes in leukocytes CDK6 ADAR SERPINE2 PLXND1 ARID4B DCAF7 TXN2 PNP CHORDC1 MAP3K8 GOLGA7 CDK5RAP3 FADS1 VPS39 ATP6V0E1 TNLG5A IFRD1 HEL-S-66 PISD MTHFD2 RAB34 PPIF PPIB ANAPC1 POM121 DDX5 RAB5C TMED10 SLC1A4 ADIPOR2 RTN4 CORO1C MRPL20 RDH10 KCNN4 SAC3D1 MPDU1 ATP6V1F SNX6 CD164 GNA13 PHC2 BRPF3 HMGA1 TBCA IGF2R BCL6 MENT SFXN1 SLC25A1 ARF4 ADPGK SNAP23 TNFAIP2 ATP2A2 SLC7A11 PRSS21 LPL MRC2 GYS1 TUBA1A SPTLC1 YWHAQ TMEM43 TMED3 TMEM109 SH3BGRL3 ACP2 NELFCD CTSC HMOX1 SCYL1 CAP1 ANXA2 PRPF40A HEL-S-26 SLC7A6 CDCP1 RFT1 FRG1 PTRH1 UNC93B1 TYMS THBS1 HEL-S-47e PTPA DNAJB1 POLR2C USP1 TPM3 SHOC2 MAPK14 CDIPT SRSF10 CA12 AP3D1 ARHG ARCN1 WDR11 POLE4 FMNL2 LAMTOR3 MCL1 CEBPB LMNB2 HEL-S-30 TRAM1 BCL2 CTNNB1 EGF EGFR SIGNALING%WIKIPATHWAYS_20260410%WP437%HOMO SAPIENS EGF EGFR signaling PTEN PIK3C2B RPS6KA3 INPP5D PLCE1 PLCG1 RPS6KA1 PDPK1 MAP4K1 VAV3 VAV2 EGFR FOXO1 MEF2D MAPK1 FOS CSK HRAS MAP3K2 JUN MAP2K1 MAP3K1 MAP2K2 BRAF MAPK14 GRB2 KRAS SOS1 RAF1 USP6NL SOS2 SH3GL3 ERRFI1 NDUFA13 INPPL1 CBLC CRKL GJA1 RPS6KA2 GRB10 RPS6KA5 AP2M1 PRKCI MEF2C RAC1 HGS JAK1 STAMBP RIN1 STAM2 STXBP1 SH2D2A GAB2 IQGAP1 VAV1 HEL-S-15 ATXN2 COX2 CREB1 CAV2 TNK2 MAP2K5 PTK6 CRK SYNJ1 RAB5A HEL-S-34 PIK3R2 AP2A1 PIK3R1 NCK2 ROCK1 FOXO4 NCK1 CBL EPS15L1 PRKCZ RAP1A EPN1 PLSCR1 EIF4EBP1 PXDN CDC42 ARF6 PCNA ASAP1 NEDD8 FOSB AP2S1 STAT1 SP1 REPS2 MAPK4 STAT3 LIMK2 PTPN11 MTOR ITCH NEDD4 RPS6KB1 SPRY2 PTPN5 MAPK8 PAK1 ERBB2 MAPK7 ARHGEF1 EGF SH3GL2 RALBP1 PLD2 PRKCB PRKCA SRC MAPK9 RALA PTK2B RICTOR RALB STAT5B CAMK2A JUND ATF1 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260410%WP5093%HOMO SAPIENS Opioid receptor pathways FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP357%HOMO SAPIENS Fatty acid biosynthesis ECHDC2 ECHS1 ACSL3 DECR1 ACSL1 ACSL6 ACSL5 PECR MECR ACSS2 SCD FACL4 FASN ACACB ACACA ACLY PC ECHDC1 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260410%WP5174%HOMO SAPIENS Ulcerative colitis signaling TGFB1 GATA3 NFATC1 NOD2 FOXP3 HLA-DMA MAF IL2RG TNF IL4 IL5 IL13 IFNG IL10 NFKB1 MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260410%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway NCKAP1L PIK3R2 PIK3R1 PIK3C2A RAC3 PLCG2 PTPN6 PIK3R3 PIK3CA LYN C1QB C1QA ITGAM NCF2 ARPC1B NCF4 TREM2 PIK3CD TREM1 FCGR1A FCER1G SYK CYBB CYBA RAC1 TYROBP SIGLEC7 LAT C1QC VAV1 VAV3 NCF1 VAV2 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260410%WP3877%HOMO SAPIENS MYD88 distinct input output pathway IL1A TLR4 MYD88 IRAK1 HEL-S-71 TLR1 JUN TIFA TLR9 TLR8 TLR10 NFKB1 TLR7 TRAF6 UBE2V1 TLR5 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260410%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma TFEB HMGB1 PARK2 VMP1 IPO8 DKFZp762B153 KRAS SQSTM1 AGER STAT3 PINK1 MDM2 NFE2L2 NFKB1 SHOC2 FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260410%WP5102%HOMO SAPIENS Familial partial lipodystrophy LPL ZMPSTE24 LIPE FNTA INS BANF1 ICMT PRRX1 CIDEC KLF9 PLIN1 MGLL PNPLA2 NR1C1 FABP4 CEBPA CIDEA PIK3CA GATA3 PPARG KLF2 KLF5 LMNB2 LMNA MAPK9 GATA2 STAT5B MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260410%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis YAP1 SPARC PBX3 TWIST1 THBS2 EDNRA COL1A1 TEAD2 COL3A1 SNAI2 TEAD3 TEAD4 GPC6 STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260410%WP430%HOMO SAPIENS Statin inhibition of cholesterol production LPL SCARB1 APOE APOB LDLR ABCA1 APOA4 SOAT1 HMGCR MTTP CYP7A1 APOC2 LIPC APOC1 ACSS1 PLTP PDIA2 ABCG8 ABCG5 DGAT1 APOA2 APOC3 APOA5 SQLE FDFT1 TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP75%HOMO SAPIENS Toll like receptor signaling IFNAR1 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 STAT1 MAP3K8 IFNA21 IFNA1 TNF CXCL11 AKT3 MAPK8 NFKBIB CASP8 CXCL9 TBK1 IRAK1 IKBKE CHUK IL12B IFNB1 IL12A FADD MAP3K7 IRAK4 TICAM1 TLR1 TIRAP TLR9 NFKBIA TLR8 MAP3K7IP1 IRF3 TRAF3 TLR7 TRAF6 MAPK13 IRF7 TLR5 TLR4 MYD88 IFNA4 CXCL8 IFNA7 IFNA6 IFNA2 CCL5 IFNA8 IKBKB CCL4 IKBKG CCL3 MAPK1 FOS MAP2K6 MAPK3 IL6 MAP2K3 MAP2K4 JUN MAP2K1 MAP2K2 NFKB1 MAPK14 MAPK12 MAPK10 RIPK1 CD40 CD80 LBP TICAM2 TLR3 LY96 SPP1 CD14 TAB3 IF1AA9 MAPK11 RAC1 IL1B IFNAR2 RELA MAPK9 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260410%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPS17 RPS6KA6 RPS16 RPL18A RPS19 RPS18 RPL36 RPL35 RPL11 RPLP2 RPL38 RPL37 RPS6KA3 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS8 RPL23 RPS5 RPS6KB1 RPL22 RPL13A RPS3A RPSA RPL37A RPL27 RPL26 RPL29 RPL28 RPL10 RPL12 MRPL19 RPL36A RPS4Y1 RPS6KA1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPS27A RPL17 RPL19 RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 FAU RPS21 RPS24 RPS23 RPS6KB2 HEL-S-310 RPL4 RPL5 RPS6KA2 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL10A RPS6 RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260410%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus GALNT16 CERK SGMS1 SPHK2 SPHK1 GALNT1 SGMS2 SGPP2 SGPP1 UGCG SGPL1 B3GALT2 B3GALT1 B4GALNT1 KDSR UGT8 B4GALT2 CERS3 B4GALT1 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260410%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders FLAD1 SLC52A2 ETFDH SLC52A1 PDSS1 ETFA COQ8A COQ9 APTX COQ7 COQ6 COQ2 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260410%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination ROCK1 GADD45G FRAT1 GSK3B FOXL2 MAPK11 FGF9 ARHA CTNNB1 MAPK1 SOX9 SRY FGFR2 AXIN1 WNT4 MAP3K1 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260410%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction HEL-S-80p CALM1 ROCK2 PLCB1 ROCK1 MYL1 ARHA IL13 RYR1 PPP1R14A GDI1 ADRB2 MYLK OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260410%WP322%HOMO SAPIENS Osteoblast signaling IBSP BGLAP COL1A1 PTH TNFSF11 TNFRSF11B ITGB3 SLC17A2 PDGFRA PTH1R ITGAV FGF23 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260410%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin MCL1 IL3 CXCL12 IL2RG TNF CXCL11 ITGA4 IL2RB CX3CL1 IL10 IL15RA BCL2 CXCL8 CCL5 CCL7 CCL4 CCL2 CXCR3 IL15 CCL3 ANGPT2 MAPK3 ANGPT1 IL6 MAP2K4 NR3A2 NR3C1 MRC1 MADCAM1 IL4 GAB3 JAK3 HLA-G NCR1 NCR2 MAPK11 NCR3 PGR KIR2DL4 CCL8 PIBF1 VCAM1 JAK1 SELL CD69 IFNG CXCR4 GATA2 STAT5B VEGFA AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260410%WP4628%HOMO SAPIENS Aerobic glycolysis augmented HEL-S-87p PGAM2 GPT ENO1 HEL-S-68p PFKM HEL-S-162eP HEL-S-30 HEL-S-49 HEL-S-133P SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260410%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis HES7 EPHA4 RIPPLY2 TBX6 NOTCH1 DLL3 MESP2 LFNG PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260410%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma PTEN CHEK2 JMJD1C MYC TLK1 HIST1H1E MYBL1 CMTR2 MAGI1 KDM6B FBXW7 ARID4B HIST1H2AK INSRR ARID5B ARID1A FOXP2 FGFR4 MORF4L1 FOXO3A NCOR1 KAT6A MAML3 BCORL1 CEBPA MYCBP SRCAP DTX4 SMARCE1 MGA ERBIN FGF16 KANSL1 NFIB PIK3CA BCOR PRKDC SETD2 ERBB2 UHRF1 EP300 CHEK1 HRAS MAP2K2 CREBBP CTBP1 ATM BRCA1 RAF1 SMC1A MYB NOTCH1 MAX KMT2C MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260410%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission PTEN BDNF AP2A1 PIK3R2 ROCK1 PIK3R1 ARHA NTRK2 STAT3 PLCG1 PIK3R3 PIK3CA GABRB3 GABRB2 GABRB1 CREM NGFR AP2A2 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 GABRG2 GABRG1 CREB1 NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260410%WP438%HOMO SAPIENS Non homologous end joining WRN XRCC5 POLM POLL NHEJ1 PRKDC RANKL RANK SIGNALING%WIKIPATHWAYS_20260410%WP2018%HOMO SAPIENS RANKL RANK signaling PIK3R2 PIK3R1 SQSTM1 CBL CDC42 IKBKB IKBKG STAT1 MAPK1 FOS MTOR PLCG1 MAP2K6 MAPK3 NFKB2 JUN MAP2K1 TRAF1 NFKB1 TRAF5 MAPK14 NFATC1 LYN SPI1 TNFSF11 TNFRSF11B MAPK8 SYK TRAF2 SRC RAC1 CHUK FHL2 RELA TNFRSF11A MAPK9 MAP3K7 PAPSS2 RELB GAB2 NFKBIA MAP3K7IP1 TRAF3 TRAF6 DOPAMINE METABOLISM%WIKIPATHWAYS_20260410%WP2436%HOMO SAPIENS Dopamine metabolism NQO1 PRKACG DDC TH PPP2CA MAOA TYR HEL-S-44 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation RHBDD2 TMEM120A SSC4D DAPK2 STYXL1 POR HEL163 PTPMT1 RAF1 EPB41L3 KIF1C SFN ZP3 ZP2 YWHAG LMNA HEL-S-102 MDH2 TMEM120B SRRM3 BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260410%WP5234%HOMO SAPIENS Bardet Biedl syndrome TMEM67 RAB23 PDE6D NPHP3 EVC2 BBS2 NEK8 BBS1 USP9X PCARE SCLT1 DCDC2 FUZ BBIP1 INPP5E TTC8 MKS1 IFT27 CEP41 TRIM32 CLUAP1 OCRL SMO SUFU PTCH1 KIF7 GLI3 DYNC2I2 INVS TRAF3IP1 IFT172 CEP164 PKD1 IFT52 FLCN ZIC2 TMEM107 CNGA1 NEK1 BBS9 BBS7 IFT57 BBS5 CEP290 SCAPER BBS4 DYNC2H1 IQCB1 CFAP418 IFT140 IFT80 CFAP410 WDR35 LZTFL1 EVC BBS10 IFT43 BBS12 RP2 IFT81 GPR161 MAK TMEM216 EFHC1 WDPCP EFHC2 CNGB1 SDCCAG8 CEP104 ARL6 ARL3 DYNLT2B CRX PKD1L1 DYNC2LI1 PKHD1 IFT74 ARL13B MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260410%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer BBC3 PTEN CHEK2 ATM PMAIP1 CASP9 CASP8 CASP3 EI24 SIAH1 SHISA5 TNFRSF10B DDB2 CYS1 BAX TP53AIP1 SESN3 ZMAT3 MDM2 PERP APAF1 NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260410%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT2 NOS2 CARM1 PRMT3 PRMT1 PRMT6 HEL-S-277 PRMT7 VISUAL CYCLE%WIKIPATHWAYS_20260410%WP5534%HOMO SAPIENS Visual cycle RDH8 ABCA4 RLBP1 RPE65 OPN1SW OPN1MW RDH12 RDH10 OPN1LW RBP3 RDH11 RBP1 RHO RDH5 LRAT NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260410%WP4255%HOMO SAPIENS Non small cell lung cancer CDK6 BAD RASSF1 PLCG2 CDK4 STAT3 FOXO3A PLCG1 ALK PIK3CA RB1 PDPK1 E2F2 E2F3 CCND1 CASP9 AKT3 CASP8 KIF5A HEL-S-61 CASP3 CRABP2 CRABP1 STK4 CDKN1A FHIT HGF TGFA RET ERBB2 MET EGFR GADD45B GADD45A GADD45G CYCS ARAF BAK1 NRAS MAPK1 HRAS CDKN2A MAPK3 RXRB EGF RXRA RXRG BAX MAP2K1 MAP2K2 BRAF GRB2 KRAS EML4 SOS1 RAF1 SOS2 JAK3 PIK3CD PRKCB POLK PRKCA DDB2 RARB STAT5B GASTRIN SIGNALING%WIKIPATHWAYS_20260410%WP4659%HOMO SAPIENS Gastrin signaling MYC BAD FOXO3A PLCG1 PIK3R3 PIK3CA CDKN1A CLDN1 KAT5 MEF2B SLC9A3 PRKD2 PRKD1 ARHGEF28 YES1 TCF4 BMP2 ELAVL1 SERPINB2 KIT RHOD EGFR RHOB CCKBR ATF2 GAS CD44 CXCL8 TFF2 HDC HDAC7 PTGS2 TJP1 FOXO1 IKBKB ANXA2 MEF2D MAPK1 FOS HRAS CDKN2A MAPK3 JUN MAP2K1 MAPK14 GRB2 KRAS SOS1 RAF1 LAMTOR3 IRS1 MEF2C RAC1 RPS6 CREB1 MMP7 CRK PIK3R2 PIK3R1 ROCK1 EIF4EBP1 CDC42 FYN ARHA SP1 STAT3 PTPN11 MTOR MAP3K11 RPS6KB1 ITGB1 BIRC5 BIRC2 BIRC3 PPARG GSK3B CCND1 ARRB2 MAPK8 PAK1 CASP3 PRKCQ CHUK NFKBIA BCL2L1 NFKB1 KLF4 IL2 CDKN1B PRKCH PRKCE PRKCA CTNNB1 SRC PXN RELA MAPK9 EGR1 VEGFA CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260410%WP2029%HOMO SAPIENS Cell differentiation index STAT3 HDAC5 LEFTY1 TLX3 TLX2 TLX1 LEFTY2 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260410%WP5130%HOMO SAPIENS Th17 cell differentiation pathway SMAD2 SOCS3 STAT1 STAT3 MTOR PLCG1 TGFB1 NFATC1 FOXP3 HLA-DMA MAPK8 IL2RA PRKCQ LAT TGFBR1 IL23A NFKBIA AHR IKBKB IF2B1 IL23R MAPK1 RORC FOS CD3G IL27 CD3E CD3D IL6 IL-21 RXRA IL27RA PPP3CA JUN CRY1 NFIL3 TBX21 IL21R NFKB1 IL6R NR1D1 MAPK14 RORA PER1 GATA3 IL17F IL17A IL2 IL4 IRF4 RARA IFNGR1 RUNX1 JAK1 IL1B HIF1A IFNG TYK2 ZAP70 LCK MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260410%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism HSD3B2 SULT1A1 UGT1A1 HSD17B2 HSD3B1 HSD17B3 SRD5A2 CYP17A1 CYP11A1 SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260410%WP15%HOMO SAPIENS Selenium micronutrient network PLG TXN SELENOK SELENOI SELENOH PRDX3 PRDX5 CBS ALOX5 INS XDH ALOX15B HEL-S-78p INSR HEL-S-2a CTH HEL-S-44 ALB ALOX5AP SAA1 SAA2 MSRB1 SELS NFKB2 TNF TXNRD3 TXNRD2 SCARB1 MPO APOB PTGS2 LDLR ABCA1 CCL2 FLAD1 IL6 CRP PTGS1 NFKB1 SERPINA3 HEL-S-97n HBB MTR PLAT KYNU SEPHS2 FGA GPX2 GPX1 GPX4 GPX3 GPX6 HEL-S-302 DIO1 HBA2 KMO IL1B HEL-75 F2 SELENOO RELA F7 IFNG SELENON SELENOM SELENOP SELENOW SELENOV SELENOT SAA4 SELENOF DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260410%WP5506%HOMO SAPIENS Disorders of NAD metabolism BST1 NAXE NAXD NADSYN1 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260410%WP5294%HOMO SAPIENS Sildenafil treatment PARK2 PDE4D GSK3B NRF1 PPARGC1A AKT3 NOS2 GUCY1A2 GUCY1B1 PDE4B ZNF746 PDE4A HEL-S-162eP TFAM PDE5A PRKG1 PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260410%WP2253%HOMO SAPIENS Pilocytic astrocytoma PTPN11 GRB2 HRAS KRAS SOS1 RAF1 BRAF NRAS NF1 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260410%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport ABCC3 HSD3B7 ABCC2 ABCB1 ABCD3 ATP8B1 ABCB4 SLC10A2 SLC51A BAAT SLC51B ABCB11 CYP7B1 CYP8B1 CYP27A1 SLCO1B1 AMACR FABP6 SLC27A5 HSD17B4 CYP7A1 SLC27A2 AKR1C4 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260410%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SELENOK SELENOI SELENOH POU2F1 CTH SP1 FOS FABP1 MSRB1 SELS JUN NFE2L2 NFKB1 CREM TXNRD3 SEPHS2 TXNRD2 GPX2 GPX1 GPX4 GPX3 RPL30 GPX6 DIO1 HEL-S-134P SEPHS1 PSTK RELA EEFSEC SELENOO TRNAU1AP SEPSECS SELENON SARS1 SELENOM SARS2 SELENOP SP3 SELENOW SELENOV SELENOT SELENOF UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260410%WP5158%HOMO SAPIENS Urotensin II mediated signaling MMP2 MMP9 PTEN SMAD2 ALOX5 CDC2 PCNA ARHA STAT3 PTPN11 DDIT3 TGFB1 GSK3B NCF2 TNF NCF4 CASP9 MAPK8 CYBB CYBA CASP3 CHUK GSK3A IRF3 NPPB AIFM2 NPPA UTS2R TRPC4 COL2A1 EGFR ESPL1 UTS2 EP300 PLN BCL2 HSPA2 NOX4 HDAC5 ABCA1 IKBKB HMOX1 MAPK1 COL1A1 MAPK3 COL3A1 IL6 CCNE1 BAX CDK2 NFKB1 CREBBP MAPK14 ACTA2 AGTR1 CTNNB1 VCAM1 IL1B RELA MAPK9 CAMK2A NCF1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C9 CYP2C8 CYP2B6 CYP2C19 CYP2C18 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260410%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR CHEK2 BARD1 PLK1 CDC2 PCNA MSH2 SP1 FOXM1 PRKDC PML RAD51 WRN XRCC5 BCL6 PARP1 BRCA2 CHEK1 RPA1 HUS1 H2AX IKBKG RAD1 DCLRE1A TOPBP1 SMARCAL1 FEN1 ATRIP UBE2D3 CEP164 ATR HERC2 RAD9A TRIM28 UIMC1 SMARCC2 RMI1 TOP3A RECQL FANCD2 EEF1E1 CDK2 MCPH1 MDM2 MCM2 ABRAXAS1 USP1 XPA MDC1 RNF8 BRCC3 RAD50 PPM1D RECQL4 BRIP1 MRE11A CDC45 ATM BRCA1 RBBP8 NBN CLSPN TP53BP1 SMC1A POLN SHFM1 FANCA PALB2 CLK2 RAD52 RFWD3 TDP1 RAD17 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260410%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A15 GLS2 ARG1 ASL NAGS ASS1 SLC25A13 OTC FOCAL ADHESION%WIKIPATHWAYS_20260410%WP306%HOMO SAPIENS Focal adhesion PPP1CC TNR MYL11 ACTN1 PTEN MYL5 MYL7 TLN2 TLN1 BLK TXK BAD MYL12A VTN CHAD MYL10 VASP SRMS CAV3 KDR TNK1 PARVA PARVB COL1A2 PIP5K1C PARVG COL5A3 SHC4 COL5A2 SHC2 ITGB5 SHC3 RASGRF1 PIK3R3 ARHGAP5 ITGB8 ITGB7 ITGB6 VWF PDGFD EMP2 PIK3CA PDGFC HEL-S-28 ITGA7 IGF1R PPP1R12B CCND3 PPP1R12C DOCK1 THBS4 PDPK1 THBS3 RELN IGF1 FLNA FLNB STYK1 ZYX MYL12B VAV3 VAV2 ROCK2 EGFR PAK6 MAPK1 PAK4 HRAS MAPK3 VEGFB VEGFC THBS1 VEGFD JUN MAP2K1 c-fgr BRAF MYLK HEL-S-80p MAPK10 IBSP ACTN4 GRB2 SOS1 RAF1 MYL2 ITGB3 ITGA2B PDGFRA COL4A2 COL4A1 PIK3CD CRKL COL4A4 COL4A6 RAC1 VAV1 CAV2 TNK2 RAPGEF1 PTK6 CRK PIK3R2 PIK3R1 ROCK1 XB RAP1A CDC42 FYN ARHA ITGB1 FLT1 ITGB4 LAMC2 LAMC1 BIRC2 BIRC3 GSK3B PDGFA ACTG1 CCND1 ITGAV AKT3 ITGA4 MAPK8 ITGA2 PAK1 ITGA1 PS1TP5BP1 HGF ITGA6 LAMA5 ERBB2 COL2A1 MET LAMA1 LAMA4 BCL2 LAMA3 CCND2 RAC3 THBS2 COL1A1 LAMB3 EGF LAMB2 LAMB1 SPP1 PRKCB PRKCA CTNNB1 SRC PXN MAPK9 MYLK2 TNC HEL114 ARHGAP35 MYLK3 MYLK4 VEGFA COMP NRF2 ARE REGULATION%WIKIPATHWAYS_20260410%WP4357%HOMO SAPIENS NRF2 ARE regulation NQO1 MAF KEAP1 GSK3B RBX1 INSR AIMP2 GCLC HMOX1 FYN MAPK8 PGAM5 GCLM EPHB2 PRKCA SRC CEBPB NFE2L2 YES1 SLC7A11 PIK3CA HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260410%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma TNFSF6 MYC CD44 CXCL8 PTGS2 NOS2 STAT3 PTPN11 MAPK3 IL6 JUN BCL2L1 NFKB1 IL6R MAPK14 BIRC5 TGFB1 GRB2 BIRC3 BRCA1 SOS1 E2F2 CCND1 CASP9 COL4A2 MAPK8 CXCR1 FRZB RRM2 CASP3 RAC1 MYOF JAK1 HNF1A HIF1A SMAD4 HEL-117 CDKN1A LEF1 TGFBR1 VAV2 VEGFA PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260410%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways MYC NCK1 CBL HEL-S-44 ARHA PLCG1 GSK3B MAPK8 PAK1 NEF3 CDKN1A TMSB4X NEFL AXIN1 NEFH TGFA ACTR3 ACTR2 DAAM1 PPP2CA PFN4 PFN1 ACTA1 PFN3 APC PFN2 ERBB2 ERBB4 ROCK2 EGFR CAMK1 FZD10 MAPK1 WNT16 MAP2K4 JUN MAP2K1 MYLK GRB2 MYL1 SOS1 RAF1 CDKN1B DVL1 FZD4 GPX1 FZD1 CTNNB1 SRC FZD3 FZD2 FZD5 FZD7 FZD9 FZD8 CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260410%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy DGAT1 DGAT2 GRB2 CAVIN1 BSCL2 HMFN0839 INS IRS1 FYN HIF1A ITGB4 LPIN1 LPIN2 LPIN3 PIK3CA AXON GUIDANCE%WIKIPATHWAYS_20260410%WP5289%HOMO SAPIENS Axon guidance ROCK1 EFNA1 NCK1 PRKCZ CDC42 CXCL12 FYN PARD3 ITGB1 EPHA2 HEL-S-28 PDPK1 GSK3B SHH GNAI1 MYL12B PTCH1 RHOD MET ROBO2 NRP1 SEMA5B ROBO3 BMPR2 ROBO1 DPYSL5 BOC EPHB1 RRAS gdf7 TRPC1 MAPK1 UNC5D HRAS RGMA SEMA7A SEMA3A NTN3 EFNB1 PARD6A ABLIM3 SLIT1 PLXNA1 SLIT3 SLIT2 LRIG2 SRGAP2 NTNG2 L1CAM CDK5 FES NGL1 RAF1 PRKCA ARHGEF12 RAC1 SRC DCC FZD3 CXCR4 WNT4 RYK HEL-S-15 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260410%WP391%HOMO SAPIENS Mitochondrial gene expression ESRRA MYEF2 MTERF3 TFB2M NRF1 PPARGC1A GABPB1 TFB1M PPARGC1B POLRMT PPRC1 CAMK4 MTERF1 SP1 GABPA HCFC1 PPP3CA CREB1 TFAM INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260410%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy RPS6KA3 ARAF MAPK1 MTOR MAPK3 MAP2K1 ACSS1 MAP2K2 BRAF RPS6KA1 DLD RAF1 PPARGC1A HEL-S-30 GPX4 HEL-S-133P PFKFB2 RPTOR RPS6KA2 GLS LDHB NAMPT MLST8 DLAT SLC16A3 CPT1A HEL-75 PKLR HEL-S-304 PDHA1 FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260410%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H3C15 PCGF1 MACROH2A2 EZH2 RNF2 H2AX EED MAPK1 SUZ12 BCL6 MAPK3 H2AZ1 H2AZ2 H3C8 H3F3B H2AB3 H2AB1 MACROH2A1 H2AJ BCOR CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260410%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer ERBB2 PIK3R4 EGFR CDK6 PIK3R2 PIK3C2G PIK3R1 PIK3C2A INS PIK3C2B NRAS CDK4 MAPK1 HRAS MTOR MAPK3 CCNE1 PIK3R3 CDK2 PIK3R5 PIK3CA IGF1R KRAS RAF1 CDKN1B CCND1 IRS1 AKT3 PIK3CD RPTOR CDKN1A STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis HSD3B2 HSD3B1 SRD5A2 CYP17A1 CYP21A2 AKR1C1 CYP11A1 PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260410%WP136%HOMO SAPIENS Phase I biotransformations non P450 PON3 PON2 ESD PON1 LIPA HEL126 CES2 CES1 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260410%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection TLR4 MYD88 IRF9 IFNAR1 TMPRSS2 ACE2 IFIH1 EIF2AK2 MAVS OAS1 OAS2 TREML4 RIGI STAT1 STAT2 TLR3 TBK1 IKBKE JAK1 IFNAR2 IRAK4 TYK2 TLR9 IRF3 TRAF3 TLR7 TRAF6 IRF7 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260410%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer STAT3 MAPK1 EGFR JAK1 MAPK3 HEROIN METABOLISM%WIKIPATHWAYS_20260410%WP2645%HOMO SAPIENS Heroin metabolism CES2 CES1 BCHE CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260410%WP4562%HOMO SAPIENS Canonical NF kB pathway CHUK REL RELA NFKBIA IKBKB IKBKG NFKB1 NFKBIE ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260410%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy SUOX ETHE1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260410%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides DGAT1 CERK SGMS1 SPTLC1 SPHK1 SGMS2 UGCG B4GALNT1 tmp_locus_29 KDSR CERS5 UGT8 CERS6 B3GNT5 A4GALT A3GALT2 CERS1 CERS2 CERS3 B4GALT1 BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation BMP2 DKFZp781O1323 FOXO1 LEFTY2 CTNNB1 BCL2L11 SMAD1 DCN WNT4 DKK1 SST SFRP1 SMAD9 METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders CBS MTR MAT1A pcap HEL-S-61p ADK CTH HEL-S-182mP CDO1 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260410%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA HSD17B4 ACOX1 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism EPHX2 PTGS2 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260410%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PTDSS2 PTDSS1 PCYT1B CHKB PCYT2 CHKA ETNK1 PEMT CHPT1 SGPL1 CEPT1 PISD AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260410%WP5526%HOMO SAPIENS Age related macular degeneration PRKAA2 PMAIP1 PPARGC1A HEL-S-32 PARP2 PRKAG1 PRKAG2 RPTOR PRKAA1 PRKAG3 MLST8 MTOR PRKAB2 SIRT1 RPS6KB1 MAPK3 PRKAB1 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway ALOX5AP B3GNT5 NFKB2 PDE4B BIRC2 BIRC3 CDKN1C TNFAIP3 THBD EPB41L4B ARL5B RGS2 DNER ENC1 ANKRD1 TNS4 SRGN IL11 FGFBP1 EDN2 TSC22D3 POU5F1 NAV3 TGFBR3 ADGRF4 CDC42EP3 SCNN1A PMP2 ANGPTL4 MFGE8 SLC26A2 ABHD2 GADD45B NR1I3 AMIGO2 BHLHB2 PRRG4 FGD4 PTGS2 GPR153 SERTAD2 STOM CCL2 MGAM PPP1R14C CAVIN2 PTGES3 PLK2 NR1i2 DNAJC15 KTN1 ACKR3 ZIC2 S100P SNAI2 SPRY1 RXRA CPEB4 JUN CCL20 NR3C1 SLC19A2 SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260410%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling NR3C1 MAPKAPK2 RAP1A RPS6KA5 MAPK1 MAPK3 GNAS HTR4 HTR6 EGR1 MAP2K1 HTR7 MAP2K2 BRAF CREB1 ATF1 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260410%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 SLC22A2 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome PCNA ITCH SIRT6 SMAD1 SMAD9 DKFZp781O1323 DLD MAPK8 BMP2 ATF2 BCL2 SIRT1 SMARCC2 RIF1 OGDHL EIF4ENIF1 FAM170B ELOA CEFIP VSTM4 NEO1 MEN1 SLC18A3 NOG RGMB BAZ1B WDFY4 PARG LRRC18 CUL5 DDX21 ARHGAP22 HSF1 HSF4 ChAT SF3B1 DRGX KDM4D C10orf53 SMARCA5 DEK TMEM273 GDF5 MYO1C JUND MYBBP1A UVSSA NLRP3 ERCC5 BMPR1A TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260410%WP5300%HOMO SAPIENS TROP2 regulatory signaling ACVRL1 PSEN2 TACSTD2 EGFR PTEN ABCC1 CLDN7 PIK3R1 BCL2 PECAM1 TLN1 CHEK1 STAT1 CDK4 PAK4 HEL113 CDKN2A CCNE1 BAX ITGB1 JUN CDK2 NFKB1 IGF1R RB1 MDK IGF2 IGF1 CDKN1B CCND1 PRKCA CTNNB1 SRC RAC1 IGF2R NOTCH1 CLDN1 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260410%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3R4 PIK3R2 PIK3C2G PIK3R1 PIK3C2A PIK3C2B PIK3R3 PIK3R5 PIK3CD PIK3CA GDNF SIGNALING%WIKIPATHWAYS_20260410%WP5143%HOMO SAPIENS GDNF signaling IRINOTECAN PATHWAY%WIKIPATHWAYS_20260410%WP229%HOMO SAPIENS Irinotecan pathway ABCC2 ABCC1 UGT1A1 UGT1A10 UGT1A9 CES2 ABCG2 CES1 BCHE SLCO1B1 CYP3A4 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome HES5 SMAD2 PRKCZ PANK4 IFIH1 INTS11 INTS13 RBX1 ARF6 VTN INTS14 INTS10 GDE1 TMEM52 GRIK2 NOC2L IFIT1 METTL14 TRIM25 SDF4 PLEKHN1 CCNL2 TNFRSF4 SAMD11 MUSK TNFRSF18 HEL-S-72p SSU72 TRAF5 PEX2 COMMD1 ATAD3A TGFB1 ATAD3C DKK3 GLTPD1 ACAP3 RER1 SCNN1D MMP23B C1QTNF12 MRPL20 PEX5 MXRA8 VWA1 AURKAIP1 TNLG2B TNLG2A CALML6 PERM1 KLHL17 TRAF2 MEPCE LRP4 UBE2J2 PARD6B PHKG2 SMAD4 BTLA GNB1 TNFRSF14 PUSL1 TAS1R3 NADK HES4 OR4F5 OR4F3 CDK11A CFAP74 ELAVL1 CD160 MIB2 ISG15 B3GALT6 PEX10 PEX12 SKI RNF223 OR4F16 MORN1 TMEM278 FNDC10 ANKRD65 INTS4 PLCH2 INTS9 AGRN SLC35E2B C1orf159 MCM2 DVL1 VEGFA OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260410%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol NR1i2 RORC IL25 INSIG1 CYP46A1 DBP THEM5 SULT2A1 CYP7A1 ACOT9 ACOT8 ACOT7 NR1H2 ACOT11 SLC27A2 ACOT12 ACOT13 EPHX2 SULT2B1 NR3A2 IL17F HSD3B7 CH25H IL17A GPR183 IL17D ACOT6 IL17C LBP IL17B ACOT4 BAAT CYP7B1 CYP8B1 CYP27A1 AMACR SLC27A5 EBP HSD11B1 HSD11B2 DHCR7 AKR1C4 CYP3A4 SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260410%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction RPS6KA1 ACE2 TOMM70 MITA NLRX1 TNF ACAD9 MAVS IL18 TERF2 NDUFAF2 TERF2IP REN NDUFAF1 SIRT6 IL6 NFKB1 TRAF3 ECSIT TRAF6 NLRP3 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260410%WP5598%HOMO SAPIENS Sodium channel in epilepsy SCN10A SCNM1 SCN8A SCN4A SCN2A SCN4B SCN2B RNF121 FGF14 FYN FGF13 FGF12 NEDD4 CALM1 GSK3B TNF PTPRN PSEN1 SCN11A PDCD10 SCN9A SCN7A SCN5A SCN3B SCN3A SCN1B CAMK2A SCN1A PRRT2 MAPK8IP2 BACE1 WEE1 NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260410%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 CAMK2G IFI27L2 PRKCZ IFI44L CAMP MED1 OAS2 RSAD2 DEFB4B CYP27B1 PLCG2 NR1i1 STAT1 STAT2 CD40LG SP1 CYP24A1 PLCE1 NFKB2 PLCB4 PLCB1 NOD2 PLCB2 TNF MAPK8 PRKCQ RELB TLR8 SP3 MAPK13 TLR4 ISG15 CXCL8 MAPK7 IFNA2 IKBKB CCL2 NRAS MAPK1 HRAS MAPK3 RXRB IL6 RXRA RXRG JUN NFKB1 TNFRSF1A MAPK14 MAPK12 PLCB3 CD40 KRAS PRKCH MAPK11 PRKCB PRKCE PRKCA IFNGR1 IFNGR2 JAK1 IFNAR2 IFNG MAPK9 TYK2 CAMK2D CAMK2A VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260410%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins NQO1 VKORC1 UBIAD1 F9 PROC F10 F2 F7 GGCX PROS1 PROZ AIFM2 MELANOMA%WIKIPATHWAYS_20260410%WP4685%HOMO SAPIENS Melanoma CDK6 PTEN PIK3R2 PIK3R1 BAD ARHA CDK4 KDR PTPN11 SHC2 GRM3 PIK3R3 PREX2 EXOC7 PDE5A PIK3CA RB1 E2F2 E2F3 CCND1 AKT3 PAK1 CALML6 CALML3 CALML4 CDKN1A KIT ERBB4 RHOB GADD45B GADD45A GADD45G ARAF BAK1 NRAS NF1 MAPK1 HRAS CDKN2A MAPK3 BAX MAP2K1 MDM2 MAP2K2 BRAF CALM1 GRB2 KRAS SOS1 RAF1 SOS2 PIK3CD POLK RAC1 DDB2 HEL114 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260410%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma CDK6 PTEN MAPKAP1 PIK3R2 PIK3R1 EIF4EBP1 EIF4E NOTCH2 CDK4 PRKAA1 MTOR NFKB2 REL FGFR1 PIK3R5 MAML1 STK11 TERT SESN1 PIK3CA SESN2 TP63 IGF1R DDIT4 BIRC2 NUMB IRF6 CSMD3 RB1 PDPK1 FKBP1A FAT1 LTBR CCND1 AKT3 CASP8 SMAD4 CDKN1A FADD TGFBR2 TRAF3 ERBB2 PRKAA2 EGFR FGFR3 KEAP1 NRAS TSC1 HRAS CDKN2A RHEB RPS6KB2 NFE2L2 NFKB1 KRAS TSC2 RPTOR CTNNB1 MLST8 AJUBA NOTCH1 RELA RPS6 RICTOR VEGFA PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260410%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH P38 MAPK SIGNALING%WIKIPATHWAYS_20260410%WP400%HOMO SAPIENS p38 MAPK signaling MYC MAPKAPK2 ATF2 SMIM40 CDC42 MAP3K5 MEF2D STAT1 HRAS MAP2K6 MAP2K4 RASGRF1 DDIT3 MAP3K1 MAPK14 RIPK1 GRB2 HMGN1 TRADD MAPKAPK5 RPS6KA5 TRAF2 RAC1 MAX MAP3K7 HEL-S-102 TGFBR1 CREB1 NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260410%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling PPP1CC CAMK2G SMAD2 GRIK2 PLCB4 PLCB1 PLCB2 SLC1A4 IGF1 ADCY3 IL10 ADCY1 ADCY8 MAPK1 FOS MAPK3 IL6 FGF2 HEL-S-80p CALM1 PLCB3 IRS1 CAMK4 GLS IFNGR1 DLAT IFNGR2 JAK1 IL1B HEL-S-15 CREB1 BDNF IL13RA1 SOCS3 INSR STAT1 STAT3 NFKB2 TRAF5 SLC7A10 TGFB1 IL1R1 DLD TNF CNTF PIG59 PSPH SLC38A1 IL1R2 ARC GRIA2 NGF SHMT1 SLC1A1 IL12B SLC1A2 SMAD4 IL12A SLC1A3 NELF SLC38A3 SLC38A5 GRIA3 TGFBR1 GRIA4 TGFBR2 LIF GRIN2B TGFBR3 GFAP GRIN3B DAO IL1A GRIN3A SLC6A9 GRIK5 GRIK3 BCL2 GRIK1 SLC2A3 GRM2 GRM4 GRM8 PHGDH TNFRSF1B LTA HEL-S-51e CAMKK1 CAMKK2 IL13 SRR LRRC8C LRRC8D SLC17A6 SLC17A7 DISC1 LRRC8E IL10RB IL10RA GRIN1 PSAT1 NFKB1 IL6R TNFRSF1A IL4 PRKCB PRKCA IL6ST GLS2 IFNG CAMK2D PDHA1 CAMK2A CAFFEINE IN NEURONS%WIKIPATHWAYS_20260410%WP5602%HOMO SAPIENS Caffeine in neurons ADORA2A ADRA1D ADRA1B ADRA1A FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260410%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma TGFB1 EGLN2 PRCC TFEB VHL SFPQ BIRC7 CTSK COL21A1 EP300 SETD2 RBX1 DVL2 ELOC HIF1A CDKN1A FH TGFA EGLN1 CREBBP VEGFA EGLN3 CADM2 NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260410%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons CDK5 CHRNB2 CHRNA3 KCNK9 CHRNA5 CHRNA6 PPP1R1B DRD2 DRD3 GNAI1 SLC18A2 DRD4 KCNK3 GNG2 GNB1 DDC TH GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260410%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione C7orf24 OPLAH GCLC HEL-S-64p PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260410%WP2878%HOMO SAPIENS PPAR alpha pathway APOA2 APOC3 SLC27A1 APOA5 MYC DBI UGT1A9 EHHADH CDC2 CCND1 CYP8B1 CDK4 CYP4A11 FABP1 NR1H3 KLK15 NR1C1 CPT2 CPT1A ACADM RXRA CYP7A1 PLTP STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260410%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 CGAS MITA NLRX1 IKBKB IKBKG NFKBIE TBK1 IKBKE CHUK IL1B IFNB1 GSDMD RELA REL F3 FCGR2A NFKBIA IRF3 NFKB1 NLRP3 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260410%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G4C PLA2G3 PLA2G5 PLA2G6 PLA2G7 SLCO2A1 PLA2G10 ALOX5 PTGS2 HRAS CDKN1A PLA2G2D PLA2G12A PLA2G4F PLA2G12B PLA2G4D PLA2G1B PLA2G4E MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response CDK6 CCND3 MYC ATM CDKN1A CCNE1 CDKN1B CCND1 H2AX RAD52 CREB1 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260410%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways HES5 TCF3 CHRM2 HEL2 VIPR2 AQP4 SOX2 C4A PKNOX1 CHRNB4 TSPYL1 POU3F2 CAV3 RUNX3 PRKAR1B PRKAR1A LMX1B TPH2 DLX2 TPH1 ADCYAP1R1 CHRNA7 C4B_2 NEUROD1 DEAF1 SPTBN1 NKX2-2 POU2F2 G6PC1 PHOX2B PHOX2A TF FEV PAH CC2D1A TP73 SNAP25 RYR2 ECE1 CTCF GNB3 YBX1 HTR2A FREP1 SNTA1 EN1 TACR1 SSTR2 YWHAZ HADHB NOS1AP AVP SLC25A4 VAMP2 IL10 ASCL1 SLC9A3 HDAC9 HSPD1 KCNJ8 NFYA REST RET GPD1L 5HT1A YWHAQ EP300 CXCL8 TLX3 MAP2 IL6 JUN CREBBP HEL-S-125m MYB GJA1 MEF2C IL1B CPT1A HEL-S-87p SCN5A SCN3B GATA2 HEL-S-162eP CREB1 NR1A2 BDNF SCN4B SP1 GCK NFKB2 NKX3-1 CEBPB SST IL1RN CREM FOXM1 HDAC1 PPARGC1A TNF PPARGC1B HEL-S-1 NGF CASP3 SLC1A3 DDC TH SP3 POU5F1 MAOA IL1A BHLHB2 YWHAG IL13 NTRK2 GRIN1 NFKB1 IL6R RORA NR3A2 GATA3 NR3C1 CHRNB2 PBX1 CTNNB1 ChAT HIF1A ACADM EGR1 VEGFA HES1 NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260410%WP5133%HOMO SAPIENS Non classical role of vitamin D CYP2R1 AGTR2 ACE2 AGTR1 CYP27B1 REN 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260410%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways EPHX2 NPC1 ACOT6 ACOT4 BAAT CYP27A1 AMACR SLC27A5 EBP DBP HSD11B1 THEM5 HSD11B2 NPC2 ACOT9 CYP7A1 ACOT8 DHCR7 ACOT7 ACOT11 SLC27A2 ACOT12 ACOT13 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260410%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death VMP1 SH3GLB1 ATG3 BCL2 UVRAG ATG9B ATG10 AMBRA1 INS ATG14 TSC2 ATG12 INSR MAP1LC3A CHAF1A ATG16L1 TSC1 ULK2 ULK1 ATG5 MIRNA BIOGENESIS%WIKIPATHWAYS_20260410%WP2338%HOMO SAPIENS miRNA biogenesis DGCR8 DROSHA DICER1 TARBP2 RAN XPO5 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260410%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling HES5 CDK6 CSNK1A1L ZMPSTE24 FNTA ICMT DICER1 TARBP2 SLC2A4 CEBPA TOR1AIP1 EMD HMGA2 CEBPB RUNX2 AGO2 CEBPD PPARG GSK3B SPP1 CCND1 CTNNB1 WNT10B TCF7L2 LMNA TCF7L1 LEF1 CSNK1A1 AXIN1 HES1 APC DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260410%WP5173%HOMO SAPIENS Disorders of galactose metabolism PYGL GYS1 GYG1 GYS2 HEL-S-19 SLC2A2 AKR1B1 SLC5A1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260410%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis TNFSF6 BBC3 MCL1 BCL2 BAD TNF CASP9 MAPK11 CASP8 BCL2L11 CASP3 FADD BAX BCL2L1 APAF1 MAPK14 MAPK13 MAPK12 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260410%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption RAB5A ADCY6 AQP4 PRKACG ADCY9 HEL-S-47e DYNC2H1 DCTN6 RAB5C DCTN5 RAB5B DCTN1 DCTN4 ARHGDIG HEL-S-77 AQP2 AQP3 ADCY3 CREB3L3 CREB3L4 CREB3L2 STX4A DYNC1I1 DYNC1H1 AVPR2 DYNLL2 RAB11A ARHGDIB RAB11B CREB3 DYNC1LI1 AVP DYNC1LI2 GNAS DNCL1 VAMP2 CREB5 DYNC2LI1 CREB1 IL7 SIGNALING%WIKIPATHWAYS_20260410%WP205%HOMO SAPIENS IL7 signaling PIK3R2 PIK3R1 IL2RG GSK3B BAD IL7 IL7R JAK3 FYN STAT1 STAT3 MAPK1 JAK1 MAPK3 PTK2B MAP2K1 STAT5B MAP2K2 EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260410%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis DGCR8 DROSHA DICER1 ERI1 AGO2 XPO5 PROTEASOME DEGRADATION%WIKIPATHWAYS_20260410%WP183%HOMO SAPIENS Proteasome degradation UBA7 HEL-S-91n PSMD13 UBE2D2 RPN1 UBE2D1 PSMB10 PSMB6 PSMD9 PSMD6 PSMD7 PSMB2 PSMD4 H2AX UBB PSMD5 PSMB3 PSMD2 UBE2D3 PSMD3 UBC PSMD1 HIST1H2AB NEDD4 UBE2B HLA-B HLA-C HLA-A HLA-F PSMB8 HLA-E HEL-S-283 PSMC6 PSMA4 PSMC4 PSMA2 PSMC1 PSME2 HLA-G HEL-117 IFNG H2AZ1 PSMD10 PSMD12 PSMD11 HEL-S-276 RPN2 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP5414%HOMO SAPIENS IDO metabolic pathway TDO2 AADAT KMO GOT2 KYAT3 IFNG KYAT1 IDO2 KYNU TNF IDO1 SLEEP REGULATION%WIKIPATHWAYS_20260410%WP3591%HOMO SAPIENS Sleep regulation UTS2R UTS2 FOS IL6 STAR ADORA2A CHRNB2 NLGN1 OXTR DRD2 NPY2R DRD3 IL18 OXT HTR2A NPAS2 NPS CACNA1I HEL-S-2 DRD1 PTGDR DLAT MRGPRX2 BTBD9 HCRTR2 HCRTR1 PER3 MTNR1B GHRH CRH TH GHRL SLC29A1 ADA BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260410%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders RRM2B DPYS RRM2 DPYD HEL74 UMPS HEL-S-29 TYMP TYMS DHODH NT5C3A RRM1 SERINE METABOLISM%WIKIPATHWAYS_20260410%WP4688%HOMO SAPIENS Serine metabolism SRR SHMT1 TYMS DHFR PSAT1 PHGDH HEL-S-51e PSPH INSULIN SIGNALING%WIKIPATHWAYS_20260410%WP481%HOMO SAPIENS Insulin signaling RPS6KA6 PTEN PIK3C2G PIK3C2A RPS6KA3 MAP3K8 PRKAA1 FOXO3A SHC2 SHC3 PIK3R3 INPP4A PIK3CA IGF1R RPS6KA1 PDPK1 SNAP25 HEL-S-61 MAP4K1 VAMP2 MAP4K2 SNAP23 MINK1 MAPK13 GYS1 FOXO1 IKBKB CAP1 MAP3K5 MAP4K3 TSC1 MAPK1 FOS HRAS MAP2K6 SLC2A4 MAPK3 MAP3K2 MAP2K3 RHEB MAP2K4 JUN MAP2K1 GYS2 MAP3K1 MAP2K2 MAPK14 MAPK12 MAPK10 GYG1 GRB2 SOS1 RAF1 MAP3K6 SOS2 MAP3K12 TSC2 IRS1 INPPL1 CBLC PIK3CD STX4A RPS6KA2 RPS6KA4 GRB10 RPS6KA5 PRKCI RAC1 STXBP1 PFKM RAPGEF1 MAP2K5 CRK PIK3R4 PIK3R2 PIK3R1 CBL SOCS3 PRKCZ SOCS1 EIF4EBP1 ARF6 INSR MAP3K10 EIF4E MAPK4 PTPN11 MTOR MAP3K11 RPS6KB1 HEL-S-31 MAP3K14 GSK3B MAPK8 PRKCQ MAP3K7 GSK3A PRKAA2 LIPE MAPK7 IRS4 GRB14 ENPP1 TRIB3 STXBP3 STXBP4 RRAD PPP1R3A KIF3A XBP1 RAB4A EHD1 EHD2 MAP3K13 ARF1 PTPRF FLOT1 FLOT2 RPS6KB2 TBC1D4 SGK1 SGK2 SNX26 MAPK6 SH2B2 PTPN1 HEL-S-42 PFKL PRKCH MAPK11 PRKCB PRKCA MAPK9 EGR1 MYO1C AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260410%WP699%HOMO SAPIENS Aflatoxin B1 metabolism GSTM1 EPHX1 HEL-S-166mP CYP2A13 CYP3A4 EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260410%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX HEL-S-298 HPGD TRPA1 ALOX5 EHHADH CYP4F2 ALOX15 ALOX15B CYP4A22 ALOX12 NR1C2 FPR2 TRPV1 LTC4S PTGR1 CYP4F12 CYP4A11 LTB4R KPG_011 NR1C1 ACOX3 ACOX1 COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260410%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway FCN1 ACE2 COLEC11 C6 C7 HEL-S-62p C9 C5AR1 C3AR1 MASP2 C8A CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260410%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling ADAM10 PSEN2 RBPJ MFAP1 MFAP2 JAG2 NOTCH2 NOTCH3 RRAS PSEN1 DNER CHUK MAML3 NOTCH1 LEF1 DLL3 MAML1 DLL4 MAML2 HES1 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260410%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling LAMA5 LAMA1 PIK3R2 LAMA3 PIK3R1 EIF4EBP1 ARHA MAPK1 PTPN11 HRAS MTOR LAMB3 MAPK3 LAMB2 LAMB1 ITGB4 MAPK14 LAMC2 LAMC1 GRB2 SOS1 IRS1 PRKCA SRC RAC1 ITGA6 FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260410%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair SUPT16H ATM H4C9 HIST1H4L NBN PRKDC SSRP1 TP53BP1 H1-1 RNF168 NASP SETD2 RAD51 XRCC5 MDC1 RNF8 SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260410%WP3944%HOMO SAPIENS Serotonin and anxiety related events 5HT1A ARC FOS PLCD4 PPP3CA NLGN1 CRH PLEK CRHR1 HTR2A PRKCB MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260410%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 AGTR2 TMPRSS2 CGAS ACE2 MITA IFIH1 MAVS RIGI NDUFB9 PHB2 CTSL NFKB2 NFKB1 ECSIT AGTR1 TOMM70 TLR3 NLRX1 ACAD9 REN NDUFAF1 TBK1 IKBKE TICAM1 IRF3 TRAF3 TLR7 TRAF6 IRF7 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260410%WP4758%HOMO SAPIENS Nephrotic syndrome ZMPSTE24 SMARCAL1 COQ2 SCARB2 CD151 PTPRO PLCE1 CTLA4 GPC5 LMX1B APOL1 SYNPO YARS LAMB2 CUBN HEL-S-47e TRPC6 ALG1 COQ6 ITGB4 WDR73 ARHGAP24 PAX2 CD2AP EMP2 MYO1E INF2 NPHS1 ACTN4 NPHS2 MYH9 COQ8B E2F3 COL4A4 WT1 COL4A3 COL4A5 LMNA CYP11B2 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260410%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 IL1B PYCARD RELA TRAF3 NFKB1 NLRP3 SPINAL CORD INJURY%WIKIPATHWAYS_20260410%WP2431%HOMO SAPIENS Spinal cord injury PLA2G5 PLA2G6 MYC AQP4 CDC2 CDK4 FOXO3A NGFR XYLT1 RTN4 AQP1 ZFP36 ROS1 SEMA6A OMG MIF PDYN BCAN RTN4R KLK8 EFNB2 TACR1 CHST11 PLXNA2 TNFSF13 SELP APEX1 GDNF CSPG4 BTG2 NCAN CXCL2 CCR2 ANXA1 MMP12 VCAN GAP43 LTB AIF1 NTN1 CD47 ROCK2 EGFR ACAN RHOB TNLG7A E2F5 PLA2G2A CXCL8 LILRB3 CCNG1 PTGS2 NOS2 MAPK1 MBP FOS HEL113 RGMA MAPK3 IL6 PPP3CA CDK2 SLIT1 SLIT3 SLIT2 COL4A1 GJA1 RAC1 IL1B EPHA4 MMP9 BDNF CDC42 ARHA TGFB1 CXCL1 IL1R1 LEP PRB1 RB1 C1QB FKBP1A PRB2 TNF CCND1 CASP3 GFAP IL1A TLR4 COL2A1 GADD45A NOX4 CCL2 GRIN1 IL2 IL4 CDKN1B PRKCA SOX9 LTB4R ARG1 IFNG FCGR2A EGR1 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260410%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation PLG F2 F13A1 F13B FGA HEL-S-78p BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260410%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPTLC1 SPHK2 SPHK1 SGPP2 SGPP1 SPTLC2 KDSR IL9 SIGNALING%WIKIPATHWAYS_20260410%WP22%HOMO SAPIENS IL9 signaling GRB2 PIK3R2 PIK3R1 IL2RG CDK9 IL9 JAK3 IL9R STAT1 STAT3 MAPK1 JAK1 MAPK3 MAP2K1 STAT5B MAP2K2 NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260410%WP4565%HOMO SAPIENS Neural crest cell migration in cancer MMP2 MMP9 PIK3R4 BDNF PAK6 EPHB6 TRIO SORT1 EPHB1 EPHB4 ARHA EPHB3 NTRK2 PAK4 KIDINS220 STAT3 TWIST1 FOS F2RL2 TIAM1 ARF1 JUN PIK3R3 PIK3R5 PIK3CA NGFR AKT3 PIK3CD PAK1 EPHB2 RAC1 CDH11 ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism EPHX2 PTGS2 PTGS1 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260410%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance PIK3R1 CD36 PRKCZ TNF INS EIF2AK2 IRS1 INSR ACSL1 MAPK8 PRKAG3 PDX1 MAFA SLC2A4 ERN1 RPS6KB1 TRAF1 PPP2CA TNFRSF1A INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260410%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition MTOR RPS6KB1 SLC2A4 RPS6 TBC1D4 IRS1 INSR MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260410%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness MAPK1 PRKCQ PLCG1 MAPK3 MFAP5 ITGB3 RYR3 JUN ITGAV CREB1 TNNC1 MTHFR DEFICIENCY%WIKIPATHWAYS_20260410%WP4288%HOMO SAPIENS MTHFR deficiency CHKA CYCS PEMT CHPT1 CASP9 CASP3 MARS1 ASMT GRIN1 EHMT1 HEL-S-61p CHDH DNMT3B ALDH7A1 TP53 NETWORK%WIKIPATHWAYS_20260410%WP1742%HOMO SAPIENS TP53 network OTX2 TP63 BOK BBC3 GADD45A MYC ATM BCL2 PMAIP1 TP73 CDKN2A CDKN1A BAX MDM2 SUMO1 TNFSF10 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260410%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A ATF4 SLC3A2 KEAP1 NFE2L2 SLC7A11 SLC7A5 BASE EXCISION REPAIR%WIKIPATHWAYS_20260410%WP4752%HOMO SAPIENS Base excision repair PCNA FEN1 APTX HMGB1 MPG OGG1 PNKP UNG POLE4 POLD3 POLD4 NTHL1 TDG POLD2 PARP2 POLE MUTYH POLG MBD4 TDP1 PARP3 RFC3 RFC4 PARP4 POLL LIG1 RFC1 APEX1 ADPRHL2 RFC2 SMUG1 NEIL3 NEIL2 POLG2 PARP1 POLE2 POLE3 NEIL1 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260410%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators CXCL13 CXCL14 CXCL16 PPBP CXCL11 CXCL9 AREG CXCL3 CX3CL1 TNFSF13 IL10 CXCL2 XCL1 CCL11 TNLG7A CXCL8 CCL1 IL9 CCL7 IF2B1 CCL3 IL25 CCL19 IL27 CCL17 CCL15 IL6 CCL25 IL-21 CCL24 CCL22 CCL21 CCL20 CCL28 CCL27 PF4 CCL26 IL17F CSF3 IL17A CSF2 IL17D CSF1 IL17C EPO IL17B IL18 IF1AA9 CCL8 IL1B CCL4L2 CXCL17 IF2D MMP9 IF2G IL36A IL36B CCL3L3 IFNA13 EBI3 IFNA14 IL36RN IFNA16 TSLP IFNA17 IL36G IFNW1 IL1F10 IL3 CXCL12 CXCL6 IFNA10 IL5 IL24 IF1IB1 PF4V1 IL19 XCL2 IFNK CCL14 IFNA21 CCL13 CTF1 IFNL2 CCL18 IFNL3 CCL16 IL33 CCL23 IL1RN IL31 IFNA1 IL37 TGFB1 CXCL1 CXCL5 TNF CNTF MMP3 IL12B IFNB1 IL12A IL11 IL23A LIF IL1A IFNA4 IFNA7 IFNA6 IFNA2 CCL5 IFNA8 CCL4 LTA CCL2 IL15 IL13 NFKB1 IL2 IL4 IL7 SPP1 IFNG OSM VEGFA DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260410%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer SIK1 SIK2 GNAS HDAC7 HDAC5 DNAJB1 CREB1 CRTC2 SIK3 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260410%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells RPIA RPE PRPS1L1 DERA HEL-S-304 VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260410%WP4271%HOMO SAPIENS Vitamin B12 disorders AMN MTRR MTR CUBN MMAA TCN2 CBLIF TCN1 MMACHC MMADHC CD320 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260410%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 LPL APOA2 APOA4 SCARB1 APOE LDLR LIPC PLTP VLDLR DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260410%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection CBFB ELOC APOBEC3G RUNX1 RBX1 CUL5 UBB BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260410%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling IGF2BP1 BAD RPS6KA3 PRKAA1 FOXO3A TIAM1 PLCG1 SHC4 SHC2 SHC3 RASGRF1 CYFIP1 NGFR RPS6KA1 PDPK1 YBX1 VAV3 PPP2CA VAV2 CAMK1 NTF3 IKBKB IKBKG MAPK1 KIDINS220 HRAS MAPK3 MAP3K2 JUN MAP2K1 MAP3K1 MAP2K2 MAPK14 MAPK10 CDK5 GRB2 ARHG RAF1 CDH2 TSC2 IRS1 CAMK4 RPS6KA5 MEF2C RAC1 RPS6 HEL-S-15 NCF1 CREB1 MAP2K5 BDNF PIK3R2 PIK3R1 NCK2 NCK1 RAP1A EIF4EBP1 CDC42 FYN EIF4E STAT1 STAT3 PTPN11 MTOR RPS6KB1 ACACB GABRB3 GSK3B NCF2 MAPK8 CRTC1 GRIA2 NGF GRIP1 CASP3 SIRPA CHUK CDKL5 FRS2 FRS3 ADAM17 DOK5 KCNN2 GRIA3 NFKBIA EIF2S2 EEF2 EIF2S1 GRIN2B NFATC4 TRAF6 DOCK3 APC KSR1 SYN1 PRKAA2 KCNA3 CNR1 NCAM1 SQSTM1 SH2B1 LINGO1 NTRK3 MAPK7 RANBP9 MARCKS CDK5R1 SORT1 NTRK1 CSNK2A1 NTRK2 PTPRF GRIN1 NFKB1 SH2B2 CTNNB1 SRC RELA MAPK9 PTK2B STAT5B CAMK2A DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260410%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor RAD50 DGCR8 DROSHA MRE11A ATM NBN DDX1 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP4970%HOMO SAPIENS Galanin receptor pathway PPARG YAP1 INS CDKN1B CDKN1C POMC FOS BCL2L11 SLC2A4 CDKN1A IL6 VAMP2 CRP CREB1 VEGFA TAR SYNDROME%WIKIPATHWAYS_20260410%WP5362%HOMO SAPIENS TAR syndrome TXN STAT3 HLA-B HLA-C HLA-A ITGB1 HLA-F HLA-E FLT3 DDIT4 HDAC2 TNFRSF14 CD160 MET EGFR ANKRD35 EIF4A3 GPR89B CCAR2 AKAP10 SLK SUMO2 MAGOH SIRT1 NUDT17 CD3D SLC34A3 HEL-S-76p HFE2 RBCK1 CFTR SLC22A4 PEX11B FURIN NFKB1 CLCN3 BCL2L13 FARP2 ZFHX3 NHERF1 UBE2I POLR3GL PYM1 PDZK1IP1 POLR3C POLR3F POLR3G MITD1 HLA-G LAMTOR1 HAMP PEX19 IFNG CXCR4 LCK HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260410%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition TGFB1 SNAI1 HDAC2 HDAC1 EZH2 PRRX1 FOXC2 KDM1A SUV39H1 SIX1 KLF8 SUZ12 TWIST1 ZEB2 ELF3 SIRT1 ELF5 GSC2 SNAI2 TCF4 VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260410%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease VCAM1 SELE SELPLG ITGB1 MADCAM1 ITGA4 ITGB7 ITGA2 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260410%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis TNFSF6 BCL2 FAS CYCS CASP9 BAK1 CASP8 CASP6 CASP3 FADD DIABLO PRF1 BAX HTRA2 APAF1 AIFM1 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260410%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol PCSK9 LDLR DRAVET SYNDROME%WIKIPATHWAYS_20260410%WP5200%HOMO SAPIENS Dravet syndrome SCN8A MAPKAP1 SCN2A SCN4B SCN2B FGF13 MTOR NFKB1 PIK3CA CALM1 TNF MAPK11 SNTA1 PRKCA MLST8 STXBP1 SCN3B RICTOR SCN3A PRR5 SCN1B KCNA2 CAMK2A SCN1A PCDH19 CHD2 HCN1 BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260410%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome G6PC2 PRKAA2 G6PC3 PRKAA1 MAPK1 PRKAB2 MAPK3 PRKAB1 CRP ACACB ACACA ACLY SLC27A2 MAPK14 MAPK12 G6PC1 MAPK10 PRKAG1 PRKAG2 MAPK8 MAPK11 PRKAG3 HMGA1 MAPK9 MAPK13 PCK2 ERYTHROPOIESIS%WIKIPATHWAYS_20260410%WP5607%HOMO SAPIENS Erythropoiesis TNFSF6 KIT HBZ GDF11 TF HBG2 EPOR TFRC HBG1 EPO HBB FAS HBE1 HBD CD79A IL3 KITLG CD34 HBA2 PTPRC GATA2 GATA1 IL3RA BLADDER CANCER%WIKIPATHWAYS_20260410%WP2828%HOMO SAPIENS Bladder cancer ERBB2 MMP2 MMP9 EGFR PIK3R2 MYC FGFR3 PIK3R1 CXCL8 TYMP HBEGF UPK3A RASSF1 ARAF NRAS CDK4 MAPK1 HRAS CDKN2A EGF THBS1 MAP2K1 MDM2 MAP2K2 BRAF DAPK2 KRAS RB1 RAF1 CCND1 RPS6KA5 SRC CDKN1A VEGFA DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260410%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets CSF2 SPI1 CSF1 IKZF1 IRF4 BATF3 ID2 IRF8 STAT3 FLT3LG RUNX2 TPO TCF4 EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260410%WP410%HOMO SAPIENS Exercise induced circadian regulation PIGF KLF9 NCKAP1 DAZAP2 BTG1 TOB1 PURA STBD1 SUMO3 UCP3 QK3 ERC2 RBPMS CEBPB CBX3 ZFR CRY1 G0S2 HEL-S-72p NR1D2 ETV6 SUMO1 PER2 PSMA4 PER1 CLDN5 H2BC15 AAG1 VAPA PPP1R3C HLA-DMA CRY2 MYF6 GSTM3 IDI1 HEL-S-22 FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260410%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling STAT3 CCR5 CCR6 FLT3 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260410%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family AHR TSLP IL9 ID2 IL5 IL15 IF2B1 IL13 RORC IL25 ZBTB16 IL6 IL33 NFIL3 TBX21 RORA GATA3 IL17A GFI1 ATL1 TNF IL4 TOX IL7 IL18 AREG HNF1A IL1B IL12B IL12A IFNG IL23A KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260410%WP5351%HOMO SAPIENS Kleefstra syndrome PAXIP1 NR1I3 WDR5 BAP1 SMARCD1 MBD5 SMARCC1 SMARCD2 SMARCD3 ACTL6B ARID1A NCOA6 ACTL6A DPY30 ASH2L ARID1B SMARCC2 SMARCA4 PAGR1 RXRA KMT2C ASXL1 EHMT1 H3F3B ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260410%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction IFNAR1 ACE2 TNF IFNA1 NFKB1 TNFRSF1A TNF ALPHA SIGNALING%WIKIPATHWAYS_20260410%WP231%HOMO SAPIENS TNF alpha signaling TXN PRKCZ BAD PLK1 NFKBIE PSMD2 MAP3K8 BTRC NFKB2 REL TRAF1 BIRC2 MAP3K14 BIRC3 TNF TRADD CASP9 TNFAIP3 PIG59 MAPK8 NFKBIB CASP8 TBK1 TRAF2 CYBA CASP3 CHUK FADD OTUD7B MAP3K7 SMPD2 SKP1 RIPK3 MAP4K2 FBXW11 NFKBIA KSR2 MAP3K7IP1 MADD PPP2CA APAF1 PTPRCAP NSMAF TANK KSR1 RFFL IKBKB TNFRSF1B IKBKG CDC37 MAP3K5 NRAS CSNK2A1 MAPK1 HRAS MAP2K6 MAPK3 MAP2K3 MAP2K4 BAX JUN MAP3K1 BCL2L1 NFKB1 TNFRSF1A CREBBP PYGL RIPK1 GRB2 KRAS SOS1 RAF1 TAB3 RAC1 DIABLO MAPK9 OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260410%WP408%HOMO SAPIENS Oxidative stress response NQO1 UGT1A3 NOX3 NOX5 NOX4 XDH HMOX1 GCLC TXN2 HEL-S-44 CYP1A1 GSTT2 SP1 FOS NFE2L2 NFKB1 MAPK14 MAPK10 TXNRD2 JUNB GPX1 GPX3 CYBB HEL-75 MAOA MGST1 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260410%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein PCSK1 GCG SLC2A2 SLC5A1 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260410%WP1995%HOMO SAPIENS Effects of nitric oxide NOS2 HBA2 MB HBB AOX1 XDH TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260410%WP5496%HOMO SAPIENS Targeted therapy in breast cancer ERBB2 ERBB4 PIK3R4 EGFR PIK3R2 KRAS PIK3C2G PIK3R1 PIK3C2A RAF1 ERBB3 PIK3C2B AKT3 PIK3CD NRAS MAPK1 HRAS MAPK3 PIK3R3 PIK3R5 PIK3CA SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260410%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome RAP1A SPAAR CTNND2 CDC42 ARHGAP44 SHARPIN SYNGAP1 DLGAP1 LZTS3 HOMER1 BAIAP2 DLG4 HRAS ADGRL1 ARHGEF7 SHANK3 ITGB1 GRIN1 PAK1 PS1TP5BP1 GRIA2 MAP3K7 SPTAN1 CAMK2A GRIN2B HCN1 LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260410%WP3601%HOMO SAPIENS Lipid particles composition LPL APOA2 APOC3 APOE APOB APOC2 LDLR PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260410%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases STAT3 KHK MYL2 AKT1S1 HEL-S-68p H3F3B SNAP23 H2AX HEL-S-30 GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260410%WP5028%HOMO SAPIENS Glycine metabolism including IMDs ISCU DLD HEL-S-302 SHMT1 LIPT2 LIPT1 GLDC AMT HSCB LIAS NFU1 GCSH BOLA3 TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260410%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H4C9 HIST1H4L H2AX HIST1H2AB H2BC15 H2AC19 H2AC14 H2BC26 H2BC12L H2BC21 H2BC9 ACD H2BC8 H2AC6 H2BC3 TINF2 H2BC1 TERF2 TERF1 H2BC17 TERF2IP H2BC12 H2BC13 H2BC14 H3-4 H2AC20 H2BC11 POT1 HIST1H2BE TPP1 H2AZ1 H2AZ2 H2AB1 H2AJ HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260410%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease SMAD2 AGTR1 FLNA MAPK8 MAPK1 ANGPT2 SMAD4 MAPK3 FBN2 FBN3 RUNX2 POSTN TGFBR1 LTBP2 TGFBR2 NR2C2 LTBP1 TGFBR3 MAPK14 FBN1 CTGF ENG MONOAMINE GPCRS%WIKIPATHWAYS_20260410%WP58%HOMO SAPIENS Monoamine GPCRs CHRM3 5HT1A CHRM1 CHRM4 CHRM5 HTR2B ADRB1 HRH1 CHRM2 HRH2 DRD5 HTR1E HTR1F HTR1D HTR1B ADRA2C HTR5A ADRA2B ADRA2A ADRB3 HTR4 HTR6 HTR7 ADRA1D ADRA1B ADRB2 ADRA1A DRD2 DRD3 HTR2A DRD4 DRD1 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260410%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes HCN4 KCNE1 HAND2 ERG KCNJ2 TMSB4X HCN2 IGF1 GJA1 CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260410%WP5601%HOMO SAPIENS Caffeine in blood vessels HEL-S-80p CALM1 PPP1R12C ADCY1 PDE4D ADCY8 RYR2 ADCY6 ADCY3 ADCY9 RYR3 GUCY1A2 PDE3B ADORA2B PDE3A PDE4B ADORA2A ADRA1D PDE4A ADRA1B ADRA1A MYLK VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260410%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases NFATC1 NR3C1 TNF IKBKB IKBKG NR1i1 CHUK MAP2K6 SMAD4 RELA IL6 MAP2K3 RXRA PPP3CA NFKBIA MAP3K1 PPP3R1 MED14 NFKB1 MAPK14 LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260410%WP4478%HOMO SAPIENS LTF danger signal response pathway IL1A TLR4 MYD88 CXCL8 AGER TNF CD14 TREM1 MAPK1 IRAK1 IL1B IFNB1 IL6 IRAK4 IFNA1 HEL110 NFKB1 TRAF6 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260410%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts B3GALT6 HS3ST3A1 CHPF XYLT2 HS6ST1 HS6ST2 HS2ST1 HS6ST3 EXTL2 XYLT1 EXTL1 CHSY1 CHST12 NDST3 CHSY3 CHST13 CHST14 HS3ST3B1 CSGALNACT1 CHST7 CHPF2 B3GAT3 CHST11 B3GAT2 GLCE B3GAT1 CSGALNACT2 HS3ST1 HS3ST2 EXT1 EXT2 UST CHST1 CHST3 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260410%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR TMEM67 RAB23 EVC2 BBS2 BBS1 SCLT1 FUZ INPP5E TTC8 MKS1 IFT27 CLUAP1 TTC23 C2CD3 CEP19 CBY1 EFCAB7 TXNDC15 TCTN3 TCTN2 TCTN1 CDK20 TRAPPC11 KIFAP3 CEP97 CC2D2A IFT56 OFD1 DYNC2I2 DYNLT1 CEP295 TRAF3IP1 ARMC9 IFT172 RPGRIP1L CCDC41 KIF3A CEP20 IFT52 IFT46 TEDC1 IFT70B TMEM107 TEDC2 FBF1 KATNB1 BBS9 TUBD1 BBS7 KIF3B IFT57 KIAA0753 BBS5 CEP192 MIB1 CEP76 RABL2B BBS4 CPLANE1 DYNC2H1 TUBE1 CPLANE2 TMEM231 IFT140 IFT20 IFT80 TMEM17 SASS6 WDR35 CEP162 LZTFL1 B9D1 EVC CIBAR1 BBS10 CEP44 IFT43 IFT25 BBS12 IFT81 TMEM216 WDPCP PIBF1 CEP104 ARL6 ARL3 DNCL1 DYNLT2B DYNC2LI1 IFT74 ARL13B LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260410%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 FADS1 ACE2 FADS2 ELOVL5 ELOVL2 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260410%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome ATR ATM RNF168 CBX3 H2AX NIPBL MDC1 RNF8 HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260410%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis CALM1 BDNF RPS6KA1 NCAM1 BCL2 PPARGC1A CCND2 CAMK4 CAMKK1 SYT2 CAMKK2 NRXN1 PRKCA NRXN3 RPS6KA5 MAPK1 DRD1 NRXN2 NGF PRL HNRNPL CAMK2A CREB1 MAPK14 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260410%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction MYD88 IRF9 IFNAR1 IFIH1 EIF2AK2 MAVS IKBKB OAS1 OAS2 RIGI IKBKG STAT1 STAT2 FOS JUN NFKB1 MAPK14 RIPK1 MAPK8 TBK1 IKBKE JAK1 CHUK IFNAR2 MAP3K7 TYK2 TICAM1 NFKBIA IRF3 TRAF3 TLR7 TRAF6 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260410%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy GPD1 PPARG HIF1A HMFN0839 CD36 HEL-S-162eP HEL-S-49 HEL-S-133P SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260410%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins CADM3 CAMK2G CADM1 CASK ATP2B1 SNW1 DAB1 KCNMA1 EPB41L3 KCNQ2 PRKCZ GRIK2 AGRN MAPK4 GRIN1 PLCB4 NEO1 CDH2 RAP1GAP TERF2IP GABRG2 CSN3 GPHN MAPK9 CHL1 EFNA5 NCDN MAP4 STX2 CLASP1 NTNG1 GRIN2B GABBR2 CAV2 KCNJ6 NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260410%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation TLR4 IL1B PYCARD NFKB1 NOTCH SIGNALING%WIKIPATHWAYS_20260410%WP61%HOMO SAPIENS Notch signaling PSEN2 RBPJ HES5 PIK3R2 SNW1 PIK3R1 EP300 FHL1 DTX1 APH1B NCOR2 MAGEA1 FBXW7 CIRSR PSENEN NOTCH2 SPEN NOTCH3 SAP30 STAT3 NCOR1 MTOR ITCH MAML3 MAML1 NFKB1 NUMB HDAC2 HDAC1 JAG2 GSK3B HEY2 HES6 PSEN1 SRC NOTCH1 SKP1 ADAM17 DLL3 DLL4 LCK MAML2 HES1 IL18 SIGNALING%WIKIPATHWAYS_20260410%WP4754%HOMO SAPIENS IL18 signaling PTEN PIK3R1 CSN2 SP1 IL18RAP PRKAA1 IMP3 IRF1 SLC12A3 RPS6KB1 IL18R1 CEBPB ACACB IL37 GSK3B NCF2 TNF CASP8 IRAK1 CASP3 CHUK MAP3K7 HEL-S-102 NFKBIA PARP1 GRIN2B TRAF6 NFATC4 ELAVL1 TNFSF6 MYD88 FAS CYCS IKBKB MAPK1 MAPK3 BAX NFKB1 TNFRSF1A TICAM2 IL18 PRKCB PRKCA CTNNB1 RELA MAPK9 GATA1 NCF1 LCK IL2 SIGNALING%WIKIPATHWAYS_20260410%WP49%HOMO SAPIENS IL2 signaling PIK3R1 CBL SOCS3 FYN STAT1 MAPK1 STAT3 FOXO3A PTPN11 HRAS MAPK3 RPS6KB1 CISH NMI MAP2K1 RPS6KB2 MAP2K2 GRB2 SOS1 IL2RG RAF1 IL2 JAK3 IL2RA CRKL IL2RB SYK JAK1 RPS6 PTK2B GAB2 STAT5B LCK CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260410%WP5304%HOMO SAPIENS Cholesterol metabolism HMGCS1 HMGCR TM7SF2 LIPG HSD17B7 PBR ANGPTL8 ANGPTL3 LRPAP1 SAR1B NPC1L1 APOH MGAT1 CIDEB VAPA ACAT2 ABCB11 CYP27A1 LPL SCARB1 NPC1 PCSK9 LIPA CD36 APOE APOB LDLR ABCA1 MYLIP STARD3 SORT1 APOA4 FABP2 SOAT1 STAR NPC2 MTTP CYP7A1 APOC2 LIPC APOC1 LPA PLTP ABCG8 SLC27A4 ABCG5 DGAT1 APOA2 APOC3 IDI1 FDPS MVK CYP51A1 DHCR24 MSMO1 SQLE EBP PMVK SC5D MVD DHCR7 LBR FDFT1 PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260410%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLCO1C1 SLCO3A1 SLCO4A1 SLCO1A2 SLC16A10 SLC16A2 SLC7A5 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260410%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis HSD3B2 POR STAR HSD17B3 SRD5A2 HSD17B6 CYP17A1 AKR1C2 AKR1C4 CYP11A1 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260410%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement ACTN1 ITGB3 MYL2 TJP1 LPP ITGAV MAPK1 PXN PRKCQ PLCG1 MAPK3 MFAP5 JUN HEL114 CREB1 MYLK THERMOGENESIS%WIKIPATHWAYS_20260410%WP4321%HOMO SAPIENS Thermogenesis RPS6KA6 RPS6KA3 ARID1A PRKACG ADRB3 PRKAA1 MTOR PRKAB2 ADCY9 SIRT6 RPS6KB1 PRKAB1 FGFR1 SMARCE1 FACL4 PRKG1 PRDM16 RPS6KA1 PPARG PPARGC1A SMARCD1 ACTG1 DPF1 ADCY3 PRKAG1 DPF3 SMARCC1 PRKAG2 CPT1C SMARCD2 ZNF516 SMARCD3 ACTL6B KDM3A KDM3B PS1TP5BP1 ACTL6A UCP1 PRKAG3 HEL-S-7a SLC25A29 ARID1B SLC25A20 BMP8A SMARCA4 FRS2 BMP8B GNAS AKT1S1 MAPK13 PRKAA2 CNR1 ATF2 GCG ADCY1 LIPE ADCY8 FGF21 ACSL3 ADCY6 ACSL1 MAP3K5 PLIN1 NRAS ACSL6 MGLL ACSL5 PNPLA2 TSC1 HRAS SMARCC2 MAP2K3 RHEB RPS6KB2 MAPK14 MAPK12 GRB2 KRAS SOS1 SOS2 CREB3L3 TSC2 CREB3L4 CREB3L2 MAPK11 KDM1A RPTOR RPS6KA2 MLST8 CPT2 CPT1A CREB3 RPS6 CREB5 CREB1 LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism EPHX2 ALOX5 ALOX15 CYTOSINE METHYLATION%WIKIPATHWAYS_20260410%WP3585%HOMO SAPIENS Cytosine methylation HEL-S-26 MBD3 TET2 TET1 TDG SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260410%WP3947%HOMO SAPIENS Serotonin and anxiety 5HT1A PLCD4 PLEK POMC HTR2A PRKCB TRPV1 ARC FOS PPP3CA EEF2K CRH FMR1 ADRA1A GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260410%WP4815%HOMO SAPIENS Glycosaminoglycan degradation GNS SGSH GALNS GLB1 HYAL2 HYAL4 HPSE GUSB HGSNAT HPSE2 IDUA HEXB HEXA ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260410%WP554%HOMO SAPIENS ACE inhibitor pathway TGFB1 AGTR2 ACE2 AGTR1 CMA1 ATP6AP2 MGRA NR3C2 CTSG BDKRB2 BDKRB1 REN KNG1 CYP11B2 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260410%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway IDI1 FDPS MVK HMGCS1 CYP51A1 MSMO1 SQLE HMGCR PMVK SC5D MVD DHCR7 FDFT1 MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260410%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation STRADB PRKAA1 PTBP1 STK11 SIX4 CTDSP1 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260410%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHAF2 SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHA SDHB ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2853%HOMO SAPIENS Endoderm differentiation SMAD2 EZH2 SOX2 TOX TET1 PTHLH VAV3 TCF4 ELAVL1 FOXO1 FOXA1 APP SOX21 MAP2K3 CEP250 HOXA1 WWC1 SOX7 WDHD1 SFMBT1 DNMT3B TBX21 FOXH1 CDYL EMSY RFX7 OTX2 RAB38 WDFY2 HPRT1 CTR9 GATA6 PRDM14 RTF1 MBTD1 EPB41L5 UBR5 NKX2-1 BPTF ATP8B2 SIAH2 FOXN3 GDF3 ZFHX4 TRERF1 SP4 LHX1 NABP2 NOTCH1 PAF1 TAF4B LEF1 PLCH1 TCF2 NODAL WNT8A PIAS1 TRIM71 ONECUT1 HOXC11 PHF6 CDC73 HHEX ZIC3 TRIM5 C1QBP JARID2 DUSP4 DUSP5 DUSP2 SLC2A12 PAX3 PARP8 NR1B3 TOX3 AEBP2 Pax9 PABPC1 STAT1 AHDC1 CAND1 BTAF1 TCEAL2 LEO1 BCORL1 KDM4A ZNF462 ELP4 ZIC5 LRPPRC MAD2L2 TNRC6C ACACA RGS10 CEBPZ TAF5 SESN1 MIXL1 TGFB1 BMP7 FOXA2 CUL4B LAMC1 CRTC1 SMAD4 EXT1 POU5F1 APC SOX17 CER1 PBX3 DKK1 SFRP1 NR3C1 CTBP2 NLK NOG GATA4 PBX1 WNT3 CTNNB1 TCF7L1 BMPR1A MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260410%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes RAB23 CDK6 EZH2 ABCG2 IGF2BP1 SERPINE2 PLXND1 ARID4B DCAF7 TXN2 PNP CHORDC1 MAP3K8 GOLGA7 CDK5RAP3 FADS1 VPS39 ATP6V0E1 TNLG5A TNFRSF10B IFRD1 HEL-S-66 PISD MTHFD2 RAB34 PPIF TERT PPIB ANAPC1 MYO1E POM121 DDX5 RAB5C TMED10 SLC1A4 ADIPOR2 RTN4 CORO1C MRPL20 RDH10 KCNN4 SAC3D1 MPDU1 ATP6V1F SNX6 CD164 PHC2 BRPF3 HMGA1 TBCA IGF2R BCL6 CDKN1A MENT CLDN1 SFXN1 SLC25A1 ARF4 ADPGK SNAP23 TNFAIP2 ATP2A2 MRC2 GYS1 KIT TUBA1A SPTLC1 RHOB YWHAQ TMEM43 TMED3 TMEM109 SH3BGRL3 ACP2 NELFCD CTSC HMOX1 SCYL1 CAP1 PTBP1 ANXA2 PRPF40A HEL-S-26 SLC7A6 CDCP1 CDKN2A RFT1 FRG1 PTRH1 UNC93B1 TYMS RHEB PPP3CA HEL-S-47e EHMT1 PTPA DNAJB1 FGF2 DNMT3B POLR2C USP1 SHOC2 CDIPT SRSF10 AP3D1 ARHG ARCN1 WDR11 POLE4 FMNL2 TDG POLD2 COL4A2 MYB PRKCI NOTCH1 BACE1 MCL1 C1QBP BDNF AP2A1 PXDN CXCL12 NF2 CAND1 GFPT1 NEDD4 SMAD1 CEBPB LAMC2 CUL4B CPNE8 LAMC1 VEZT TMEM41B PWP1 RRP8 MTRR TCL1A DHX57 LOC541469 RAVER2 CIAO2A SEC62 HOXA5 HEL-S-30 ARL10 ITGA2 MBNL1 SLC38A1 HEL-S-303 TRAM1 CBFB CACNA2D1 FNDC3B CSNK1D FNDC3A CARHSP1 WDR82 OTULINL HACD3 IQGAP3 UBE2J1 FXR2 COMMD9 GRPEL2 CEP72 ATP6V1C1 VTI1B HARS1 RAB27B BRI3BP UHRF1 PEDS1-UBE2V1 MOV10 PPP5C POLA2 NCEH1 MAPK7 STRN ANP32B FERMT2 MYLIP HOXD8 RNP24 RCOR1 GFM1 MAGT1 MEOX2 PANX1 COIL SERP1 DHX15 GNPNAT1 TMED7 MRPS24 ELMOD2 TMT1A PSAT1 AP3B1 CSDE1 VAMP3 PRIM1 MRPS33 SSNA1 AKAP8 NAPG NT5E PGRMC1 PPP1R7 TAF9B MPZL1 MTX1 SMC1A SPRYD4 CDKN1B TRMT1 TTC9C ATAT1 TMEM59 SPCS3 TPPP3 GPAM NFIA AXL SNX15 PKN2 TRIP13 LAMTOR5 LY6K SLC25A13 GEMIN2 FAR1 LTN1 MSI2 ABHD10 ABHD11 NARS1 ARID2 POGLUT3 KPNA3 BACH1 RARS1 ATG9A STX7 UBE4A CDKAL1 RAB30 SYPL1 ADAR GPD2 NCL PLK1 PTMAP7 GEMIN7 SRSF9 RAI14 SDCBP NPRC GAS2L1 SLC4A10 PURA TNFRSF10A GNL3L TRPV6 UBE2S P4HA2 CHMP2A SRPRB DKFZp761E1322 PICALM DOCK5 CALCOCO2 DOCK7 CYR61 SYNE2 SYNE1 SNAP29 UTP15 HSDL1 MARS2 RBM19 SIGMAR1 PPP2R5C RCN2 RBMS1 SEC23A LUZP1 NUFIP2 NXN PLAG1 HSD17B12 GNA13 MRM1 AURKB TP53INP1 ASH2L SH3BP4 ZNF622 ABCF2 SLC25A22 PDLIM7 SLC25A24 SLC12A2 FBXW11 GALNT7 NHERF2 TM6SF1 SLC4A7 CPOX RQCD1 SLC25A32 LPL BET1 EGFR CYP1B1 ATG3 GALNT1 NRP1 CHAF1A HEL-S-273 HEL-S-108 TPM3 MAPK14 MAPK12 TPM1 KRAS LAMTOR3 GSTM4 IRS1 CYP51A1 VCAM1 EIF4E NOTCH2 ARID1A PDE3A PPP3R1 SUCLG2 RB1 E2F3 LMNB2 CCND1 CDKN1C TGFBR2 NT5C3A MET AMIGO2 BCL2 PTPRF FADS2 ELOVL5 CTNNB1 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260410%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9 CYP3A4 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260410%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260410%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism SLC44A1 CHDH ALDH7A1 MACROPHAGE MARKERS%WIKIPATHWAYS_20260410%WP4146%HOMO SAPIENS Macrophage markers CD74 CD163 CD83 CD68 F3 LYZ CD14 ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260410%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer BLM CHEK2 PTEN MYC SMAD2 BARD1 CDKN2B BAD PLK1 CDC2 CDC25B MSH6 MSH2 CDK4 NOXA1 PIK3CA DOCK1 SMARCD1 SMARCC1 SMARCD2 SMARCD3 ACTL6B ACTL6A ARID1B SMARCA4 CDKN1A MAP4K1 SPINK1 EIF4E1B FKBP5 ETV4 TSC1 MAPK1 FOS HRAS CDKN2A FOXA1 MAPK3 RHEB JUN MAP2K1 CDK2 MDM2 MAP2K2 MAPK14 GRB2 SOS1 RAF1 TSC2 CRKL RPTOR HSD3B2 JAK1 RAPGEF1 CRK RAP1A EIF4EBP1 ARID1A STAT1 SP1 STAT3 PTPN11 HSD17B1 MTOR HSD17B2 ERG HSD3B1 SPRY2 HSD17B3 HSD17B4 F13B HSD17B7 CYP17A1 CPN1 RB1 PRKDC KLK3 CCND1 CASP9 MAPK8 PAK1 CASP8 CASP3 HGF BCL2 CHEK1 ATR SMARCC2 SPRY1 BAX RAD50 MRE11A ATM BRCA1 CDKN1B PXN PTK2B RICTOR ATF1 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260410%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions MMP9 SMAD2 EBI3 FOXO4 SOCS3 CDC42 STAT4 CXCL12 STAT1 STAT3 FOXO3A CTLA4 NFKB2 IL33 NKX2-2 CXCL1 TGFB1 IGF1R FOXP3 IL2RG IGF1 TNF ROS1 PDGFA ITGAV IL2RA ITGA2 IL2RB AREG SSTR2 SIRPA CCR8 IL12A CNP CSPG4 CCR6 IL10 TGFBR1 TGFBR2 TGFBR3 HEXB TLR4 CX3CR1 AIF1 MYD88 CD47 EGFR CD44 CCL1 CD68 FOXO1 TNFRSF1B IKZF2 CCN3 NKX6-2 OLIG1 NOS2 OLIG2 FAM20C MBP APOD NKX6-1 KLRG1 MOG IL6 IL10RB MCAM IL10RA TMEM119 PDCD1 HTR7 CCL20 NFKB1 MAPK14 CD80 ITGB3 IL2 IL4 PDGFRA SPP1 JAK3 IL18 SOX9 RAC1 JAK1 IL1B GSDMD IFNG TYK2 STAT5B IL12RB1 OSM NLRP3 VEGFA ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway UGT1A3 NR1I3 UGT1A9 CYP2C9 EHHADH FOXO1 CYP2B6 CYP2C19 NCOA1 SP1 RXRA SULT2A1 PTPA UGT1A4 CYP2A6 DNAJC7 ABCC3 SULT1A1 ABCC2 ABCB1 UGT1A1 PPARGC1A SMC1A NCOA6 CYP4A11 ALAS1 CYP3A4 SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260410%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence S1PR2 S1PR5 PLCB1 RPP38 SPTLC1 GLB1 SPHK1 RB1 SGMS2 SGPP1 UGCG PRKCB KDSR CDK4 PRKCA MAPK1 MTOR CDKN1A CERS2 CDK2 TERT S1PR1 DEGS1 ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260410%WP474%HOMO SAPIENS Endochondral ossification MMP9 STAT1 RUNX3 ALPL HMGCS1 FGFR1 TGFB1 BMP7 IGF1R IGF2 IGF1 CDKN1C PTCH1 FRZB IHH CHST11 GLI3 THRA PTH1R PTHLH COL2A1 ACAN FGF18 FGFR3 ENPP1 KIF3A RUNX2 FGF2 CALM1 ADAMTS4 GHR PTH ADAMTS5 COL10A1 TIMP3 PLAT SOX6 NKX3-2 SOX5 SPP1 DDR2 CAB39 CST5 SCIN BMP6 GH1 MGP SOX9 MEF2C STAT5B VEGFA BMPR1A PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2876%HOMO SAPIENS Pregnane X receptor pathway ABCC3 UGT1A3 ABCC2 ABCB1 UGT1A1 UGT1A9 CYP2C9 PPARGC1A FOXO1 CYP2B6 CYP2C19 NCOA1 SLCO1B1 NR1i2 CYP4F12 CYP3A7 SRC SRPX2 RXRA SULT2A1 UGT1A4 CYP2A6 DNAJC7 CYP3A4 ANGIOGENESIS%WIKIPATHWAYS_20260410%WP1539%HOMO SAPIENS Angiogenesis MMP9 TIMP3 PDGFRA KDR MAPK1 SRC PLCG1 ANGPT1 HIF1A SMAD1 FGFR2 FLT1 FGF2 CREBBP MAPK14 VEGFA PIK3CA MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260410%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma HIF1AN VEGFB HIF1A VEGFC VEGFA HES1 ATM SIGNALING%WIKIPATHWAYS_20260410%WP2516%HOMO SAPIENS ATM signaling CHEK2 GADD45A ATF2 TLK1 CHEK1 CDC2 H2AX IKBKG MDM4 RAD9A CCNE1 JUN CDK2 MDM2 MDC1 CASP2 RAD50 RIPK1 MRE11A ATM BRCA1 NBN TP53BP1 TP73 SMC1A RAD51 PIDD1 CDKN1A CCNB1 MAPK9 CRADD CREB1 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260410%WP2289%HOMO SAPIENS Drug induction of bile acid pathway ABCC3 ABCC2 ABCB1 NR1I3 SLC51A BAAT SLC51B ABCB11 NR1i1 SLCO1B1 NR1i2 NR1H4 SULT2A1 CYP7A1 CYP3A4 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome UGT1A10 UGT1A9 IRF8 PER2 HEL-S-28 CXCL11 SH3BP4 ASCL1 GYS1 UGT1A3 EGFR MAP1LC3A PDX1 JUN PDCD1 UGT1A4 CALM1 BOK UGT1A1 ITGB3 HES6 MEF2C RAC1 IL1B RPS6 CXCR4 MROH2A DGKD NDUFA10 HJURP ERFE KLHL30 GABARAPL2 GABARAPL1 EEF1A1 THAP4 RRAGA RRAGB IL13RA1 RRAGD CALCA CALCRL TWIST2 AGAP1 GABARAP NEU4 CXCL12 OR6B3 TRPM8 OR6B2 NEDD8 UBE2F MTERF4 RAB27A COPS8 COPS9 SNED1 RTP5 RNPEPL1 PRH ING5 SEPT6 MAP1LC3C KIF1A GAL3ST2 ILKAP MYOG AQP12B AQP12A ITPK1 DUSP28 ANO7 OTOS ARL4C MYOD1 USP40 AGXT TNF PDGFA ARF5 DTYMK ASB18 CENPA CYTH2 GBX2 GPC1 SPP2 D2HGDH UGT1A8 ANKMY1 CYTH1 UGT1A7 SEPTIN2 SEPTIN4 MLPH CAPN10 NFKBIA RAB17 RAMP1 ASB1 TRAF3 DKFZp762B153 ABCA1 TRAF3IP1 ACKR3 DISC1 ARF1 FARP2 PPP1R7 HAMP PRL MAP4 HES1 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP5171%HOMO SAPIENS Leukotriene metabolic pathway PTGR1 ABCC1 ALOX5 DECR1 CYP4F3 DPEP2 ALOX5AP LTC4S DECR2 WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members PARP10 PLK1 DVL1 RBX1 DVL2 DVL3 CTNNB1 TNK1 BTRC AXIN1 SKP1 PARP1 TNK2 APC BDNF TRKB SIGNALING%WIKIPATHWAYS_20260410%WP3676%HOMO SAPIENS BDNF TrkB signaling TRPC3 BDNF ADCY1 EIF4EBP1 NRAS NTRK2 HOMER1 MAPK1 TSC1 DLG4 HRAS MTOR PLCG1 RPS6KB1 RHEB TRPC6 GRIN1 MAP2K1 BRAF GRB2 RPS6KA1 KRAS SOS1 TSC2 ARC GAB2 EEF2K CREB1 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation TLR4 TNFRSF13C CD79B SPIB MYC TCF3 ICOSLG POU2AF1 EZH2 ID3 CD79A CCND2 IRF8 STAT3 CDKN2A IL6 BCL2L1 IL21R NFKB1 POU2F2 LYN SPI1 CCND3 CD40 BCR TLR3 CDKN1B IRF4 SYK MEF2C BCL6 CDKN1A TLR1 MEF2B TLR9 TLR8 TLR10 TLR7 TCF4 TLR5 MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260410%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 ARCN1 CDKN1A ID1 ID2 USP1 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260410%WP2328%HOMO SAPIENS Allograft rejection PRKCZ CXCL12 C4A CXCL13 IL5 STAT1 CD40LG CTLA4 HLA-B PECR HLA-C HLA-A HLA-F C4B_2 HLA-E TGFB1 FOXP3 ABCB1 HLA-DMA C1QB C1QA TNF CXCL11 CASP9 IL2RA CASP8 CXCL9 CASP3 IL12B GABPA IL12A GDNF C1QC IL10 IL1A HARS1 TNFSF6 CXCR5 CXCL8 FAS LRRK2 TUBA1B GNLY HLA-DOA HLA-DOB HLA-DPA1 BHMT2 IF2B1 IL13 HLA-DQB1 C2 CSNK2A2 HLA-DMB HEL113 CCL19 HLA-DQA2 MICA CD55 HLA-DQA1 IL-21 HLA-DRB5 HLA-DPB1 CCL21 HLA-DRA HLA-DRB1 IL17A CD40 CD80 AGTR1 IL2 IL4 PDGFRA HLA-G IL1B IFNG C6 PRF1 C7 HEL-S-62p C9 C8A VEGFA SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260410%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TBK1 IKBKE IFNB1 TOMM70 MAVS IRF3 RIGI TRAF3 TRAF6 MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260410%WP4316%HOMO SAPIENS miRNA degrading enzymes PNPT1 EXOSC4 XRN1 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260410%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle ADAM10 DUSP14 IL1A IL1R1 NR4A3 ATF3 HBEGF EIF4EBP1 IL18 EIF4E ANKRD1 IFNG IFRD1 JUND MYOG HEL-S-52 CYR61 VEGFA GDF8 CREATINE PATHWAY%WIKIPATHWAYS_20260410%WP5190%HOMO SAPIENS Creatine pathway SLC6A8 HEL-S-20 HEL-S-29 FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260410%WP5061%HOMO SAPIENS Fatty acid transporters FABP9 DBI FABP5 CD36 ACSL3 ACSL1 ACSL6 ACSL5 FABP6 FABP1 FABP2 FABP4 FACL4 SLC27A4 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260410%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming MYC KLF4 EGR1 SOX2 TRIM71 POU5F1 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260410%WP5050%HOMO SAPIENS TCA cycle in senescence PDP2 ME1 FH ME2 PDHA1 HEL-S-32 BRAF AUTOPHAGY%WIKIPATHWAYS_20260410%WP4923%HOMO SAPIENS Autophagy PRKAA2 PIK3R4 ATG9A DKFZp762B153 ATG3 UVRAG AMBRA1 ATG14 ATG12 ATG16L1 PRKAA1 MTOR PRKAB2 PRKAB1 ULK1 DEPTOR RB1CC1 ATG101 WIPI2 PRKAG1 PRKAG2 RPTOR PRKAG3 MLST8 AKT1S1 ATG5 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260410%WP3995%HOMO SAPIENS Prion disease pathway NCAM1 EP300 BCL2 FYN MAPK1 STAT3 MAPK3 RXRA FGFR1 NFKB1 POU2F2 HEL-S-125m RAD21 SPI1 SMC3 IRF4 CTCF HEL-S-89n CASP12 PRNP TBP BCL11A HEL-S-269 PAX5 BATF CASP3 MEF2C RFX5 CHD2 CREB1 ESTROGEN METABOLISM%WIKIPATHWAYS_20260410%WP697%HOMO SAPIENS Estrogen metabolism NQO1 GSTM1 UGT1A3 SULT1A1 UGT1A1 CYP1B1 UGT1A9 CYP1A1 STS SULT1E1 ARSL UGT2B7 CYP3A4 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260410%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport MTR DHFR HEL-S-51e SHMT1 TYMS SLC46A1 HEL-S-70p MTHFS FTCD MTHFD2 MTHFD1 MTHFD2L FOLR1 SLC19A1 IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260410%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis NARF ISCU LYRM4 ABCB7 FDX1 FDXR CIAO2B FXN NUBP1 NUBP2 HSCB NFU1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260410%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADRA2A HEL-S-7a ADCY9 ADRB1 ADCY1 ADCY8 ADCY6 ADCY3 ADRA1D ADRA2C ADRB2 ADRA2B ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260410%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment CHUK IL6 RELA TNF NFKBIA IKBKB IKBKG NFKB1 MUC1 NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260410%WP4564%HOMO SAPIENS Neural crest cell migration during development MMP2 MMP9 PIK3R4 BDNF PAK6 EPHB6 TRIO EPHB1 EPHB4 ARHA EPHB3 PAK4 STAT3 TWIST1 FOS F2RL2 TIAM1 ARF1 JUN PIK3R3 PIK3R5 PIK3CA NGFR AKT3 PIK3CD PAK1 EPHB2 RAC1 CDH11 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260410%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer TIGAR PGAM1 PYCR2 PAICS HEL-S-51e GLUD1 ALDOB HK3 FH MDH2 PSAT1 FASN SDHB ACLY RPIA SUCLG2 PFKL ACO2 GOT2 HEL-S-30 PSPH HEL-S-133P GLS SLC16A3 ENO1 PDHA1 HEL-S-68p HEL-S-162eP HEL107 CILIARY LANDSCAPE%WIKIPATHWAYS_20260410%WP4352%HOMO SAPIENS Ciliary landscape MFAP1 BBS2 NEK8 BBS1 FUZ DCAF7 BBIP1 MSH2 TTC8 DGKE MKS1 SMC4 IFT27 MAEA APMAP RAB2A CLUAP1 ARMC8 MYL6 TIPRL ERF ARL8B INTU COPS7A HEL-S-296 DOCK5 CDH23 NUP88 CDR2 AAR2 POM121 CTSA DDX5 TFAP2B SNAP29 TFAP2C UBE2H TFAP2D TFAP2E EXOC6B CNOT10 LSM4 COPS4 COPS6 IFT22 EHD3 COPS5 CNOT1 WNK1 LCN2 RANBP10 DYNLRB2 MCM7 ZMYND19 MCM9 NEF3 MCM10 MYL6B RPGR NEFL CEP170 TMED1 DFNB31 NINL RAB8A EIF5B RQCD1 RBM14 NUDC CNOT6L EXOC8 NUP133 GLB1 EIPR1 DYNLT3 RAB3IL1 ECHS1 ARFGAP3 YAP1 RABEP2 ACSL3 NME8 MCM3 EXOC4 EXOC3 EXOC6 MCM5 MCM6 EXOC5 MAPRE2 EXOC2 HEL113 PAFAH1B1 CCDC40 EXOC1 IFT70A WDR26 ANKS3 VPS4A HEL-S-47e USH1C RAB21 RMND5B GDI1 DNPEP CREBBP PGRMC2 RMND5A SNRPB2 CALM1 UQCC NDUFA9 NDUFA5 MKLN1 GID4 RAB14 VAPB XPNPEP3 GID8 YPEL5 GLA DYNC1H1 DYNLL2 RAC1 DYNC1LI1 DNCL1 IQGAP1 H3F3B PSMD12 WEE1 HEL-S-91n PSMD13 UBE2D2 CBS PSMD7 COPS8 LRPPRC EXOC7 PSMC6 PSMC4 HDAC2 HDAC1 RB1 IQGAP3 APC RHBDD2 RANBP9 CEP97 IFT56 STOM DYNC2I2 DYNLT1 TRAF3IP1 IFT172 IFT52 IFT46 IFT70B BBS9 BBS7 IFT57 TBC1D4 BBS5 MCM2 EXOSC4 NFKB1 CEP290 BBS4 SSNA1 IQCB1 CTBP2 IFT20 IFT140 IFT80 LZTFL1 IFT25 IFT43 DVL3 IFT81 TFAP2A CTNNB1 EFHC2 HTRA2 DYNLT2B RALB CAMK2A IFT74 ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260410%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway NQO1 TMPRSS2 CXCL8 ACE2 KEAP1 IKBKB CCL2 HMOX1 GCLC IKBKG IL6 RXRA GUCY1A2 GUCY1B1 NFE2L2 NFKB1 TNF GCLM MMP3 CHUK IL1B RELA IL12A NFKBIA IRF3 SLC7A11 ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260410%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway RPS6KA6 PIK3C2G PIK3C2A RPS6KA3 MAP3K8 PRKAA1 FOXO3A NR1H3 PRKAB2 PRKAB1 SHC2 SREBF2 SHC3 SCD SESN3 PIK3R3 FASN ANGPTL8 PIK3CA G6PC1 SLCO1C1 RPS6KA1 PDPK1 SLC16A2 PRKAG1 PRKAG2 PRKAG3 THRA MAP4K1 MAP4K2 MINK1 MAPK13 CYP3A4 LPL GYS1 FOXO1 CAP1 MAP3K5 MAP4K3 TSC1 MAPK1 HRAS MAP2K6 SLC2A4 MAPK3 MAP3K2 MAP2K3 RHEB MAP2K4 MAP2K1 MAP3K1 MAP2K2 MAPK14 MAPK12 MAPK10 SOS1 RAF1 MAP3K6 SOS2 MAP3K12 TSC2 IRS1 PCK1 CBLC MLXIPL PIK3CD FBP1 RPS6KA2 RPTOR TRIP10 RPS6KA4 RPS6KA5 MLST8 NR1A2 RAPGEF1 MAP2K5 CRK PIK3R4 MAPKAP1 PIK3R2 PIK3R1 CBL INS EIF4EBP1 INSR MAP3K10 EIF4E MAPK4 MTOR MAP3K11 RPS6KB1 EXOC7 HEL-S-31 MAP3K14 GSK3B MAPK8 MAP3K7 GSK3A PRKAA2 MAPK7 IRS4 CYP2B6 MAP3K13 RXRA FLOT1 CYP7A1 FLOT2 RPS6KB2 ABCG8 ABCG5 MAPK6 PTPN1 HEL-S-42 MAPK11 MAPK9 RICTOR DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260410%WP5053%HOMO SAPIENS Development of ureteric derived collecting system BMP2 GDF11 BMPR2 NR1B3 ETV4 SPRY1 SMAD1 DCN PAX2 TGFB1 BMP7 FST SHH CCND1 RARA SMO SIX1 HOXD11 CELSR1 HOXA11 GRIP1 SALL1 BMPER GLI3 SIX2 GPC3 GDNF EYA1 CRIM1 ETV5 RARB BMP5 CTDNEP1 FRAS1 ANOS1 FREM1 RET BMP4 FREM2 BMPR1A HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260410%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 FOXE1 HR RBPJ Nbla10317 HOXC12 FOXQ1 TCF3 CASP14 SOSTDC1 KRTAP3-3 PHLDA1 IGFBP5 MSX2 SOX2 KRTAP15-1 SPINK6 KITLG SPINK5 GTPBP4 NOTCH2 FOSB ADAMTS20 DSG1 RUNX3 GAS1 S100A4 DSG4 GPRC5D DSC2 ZBTB16 GPR49 DLX3 SMAD1 KLK5 KLK4 KLK6 LRIG1 PERP KRTAP6-1 KRTAP2-4 MSX1 ELANE GSDMA TP63 KRTAP8-1 NFATC1 DKK3 KLK13 KLK14 FOXN1 KRT19 GJB6 CD200 ATL1 IGF1 SMAD4 ADAM17 DKK4 BMP4 TCF4 EGFR CD133 FOS DKK1 JUN SFRP1 NFKB1 CTGF GATA3 NR3C1 EGR2 FST WIF1 CD34 FZD1 BMP6 CTNNB1 SOX9 NOTCH1 IFNG LEF1 BMPR1A CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260410%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II HEL-S-130P CMA1 CTSG REN SPINA BIFIDA%WIKIPATHWAYS_20260410%WP5150%HOMO SAPIENS Spina bifida SHMT1 MTRR MTR AHCYL2 MAT1A MTHFD1 DNMT3B ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260410%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma NR3C1 PLCB3 PLCB1 PLCB2 MYL4 MYL1 ADCY1 MYL2 ADCY8 MYL3 ADCY6 ADCY3 PRKAR1B PRKAR1A ADCY9 GNAS CREB1 ADRB2 PLCB4 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260410%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway PIK3R4 PLA2G6 SPTLC1 ATG3 ATG10 ATG14 ATG12 MAP1LC3A ATG16L1 PRKAA1 TSC1 MTOR RHEB ULK1 ACACA STK11 DEPTOR RB1CC1 ATG101 PANK2 WIPI2 WDR45 TSC2 DCAF17 WIPI1 C19orf12 RPTOR CP COASY FA2H MLST8 ATG2A FTL AKT1S1 ATG5 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP23%HOMO SAPIENS B cell receptor signaling CRK MYC PIK3R2 NFATC2 PIK3R1 NCK1 CBL STM7 BLK CD79A CDC42 FYN INPP5D PLCG2 PIP5K1A MAPK4 PTPN11 PLCG1 PTPRC PIP5K1C REL PTPN6 LYN RPS6KA1 PDPK1 GSK3B MAPK8 SYK CD81 CHUK BLNK BCL6 GTF2I MAP3K7 CR2 MAP4K1 LAT2 BTK HCLS1 NFKBIA CARD11 GSK3A DAPP1 VAV2 BCL10 CD19 PTPN18 NFATC3 TEC TIEG2 CD79B PIK3AP1 CD22 ATF2 FOXO1 IKBKB IKBKG MAPK1 HRAS MAP2K6 JUN MAP2K1 MAP2K2 BRAF NFKB1 MAPK14 GRB2 SOS1 RAF1 RASGRP3 CRKL PRKCB RAC1 RELA MAX MAPK9 GAB2 VAV1 CAMK2A CREB1 LCK RAPGEF1 MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260410%WP3298%HOMO SAPIENS Melatonin metabolism and effects CYP1B1 ACHE ADRB1 AANAT APOE MTNR1A FOXO1 CYP2C19 EDN1 CYP1A1 MAP2 SIRT1 CSNK1E ASMT CRY1 NFKB1 PER2 PER1 CALM1 SULT1A1 CRY2 GSK3B ECE1 PRKCA IRAK1 CSNK1D PER3 MTNR1B CAMK2A MAOA TRAF6 ADIPOGENESIS%WIKIPATHWAYS_20260410%WP236%HOMO SAPIENS Adipogenesis NR1H3 NR1C1 DDIT3 SCD WWTR1 IGF1 RBL2 MIF UCP1 FRZB HMGA1 HNF1A CDKN1A MEF2B BMP4 LPL BMP2 AHR RBL1 BSCL2 FOXO1 NCOR2 KLF6 MEF2D SLC2A4 IL6 IRS1 PCK1 GH1 NAMPT MEF2C GATA2 CREB1 SOCS3 SOCS1 INS STAT1 SP1 STAT2 STAT3 NCOR1 CEBPA CEBPB MIXL1 TGFB1 LEP PPARG RB1 PPARGC1A TNF MBNL1 LMNA LIF GADD45B GADD45A ZMPSTE24 FAS LIPE ID3 CNTFR CISD1 IRS4 GTF3A PRLR ADFP TRIB3 CFD NCOA1 NDN PLIN1 WNT5B NR2F1 BMP3 CYP26A1 TWIST1 BMP1 CELF1 CYP26B1 PTGIS ASIP RETN RXRA SPOCK1 RXRG E2F4 GDF10 SFRP4 KLF7 PNPLA3 CEBPD RORA GATA3 NR3C1 EGR2 KLF15 GATA4 KLF5 DVL1 RARA NR1C2 WNT1 FOXC2 FZD1 CTNNB1 WNT10B IL6ST HIF1A STAT5B LPIN1 LPIN2 OSM LPIN3 PCK2 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2276%HOMO SAPIENS Glial cell differentiation MBP CNP GAP43 FREP1 HEL70 EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260410%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells TLR4 MMP9 EGFR PTEN IGF1 GATA4 SPP1 HEL-S-44 STAT3 KDR CD81 EGF IL6 HEL-S-102 CD63 ETS2 BIRC5 RETINOL METABOLISM%WIKIPATHWAYS_20260410%WP5188%HOMO SAPIENS Retinol metabolism DHRS4 SDR16C5 CYP2W1 DHRS9 HEL-S-53e AWAT2 RPE65 PNPLA4 AOX1 BCO1 RDH12 CYP1A1 LRAT CYP3A7 CYP2A6 ADH1A ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP138%HOMO SAPIENS Androgen receptor signaling PTEN PIK3R2 ROCK1 PIK3R1 CDC42 ARHA SP1 STAT3 NCOR1 LIMK2 SMARCE1 CARM1 HDAC1 RB1 GSK3B FLNA CCND1 SIN3A SMAD4 FHL2 KAT5 ROCK2 EGFR RHOB EP300 SMIM40 NCOR2 FOXO1 PAK6 NCOA1 RAD9A SIRT1 RAN CCNE1 RUNX2 JUN MDM2 SUMO1 CREBBP UBE2I BRCA1 TGFB1I1 UBE3A EFCAB6 ZMIZ1 HEL32 KAT7 KDM1A TGIF1 PIAS2 TLE5 CTNNB1 KAT2B ZNF318 RAC1 FKBP4 SRC RNF6 HEL-S-99n RNF4 RELA HEL-S-67p PSMC3IP ETV5 BAG1 PATZ1 PIAS1 NR0B2 NR2C2 STUB1 CREB1 RLN1 NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260410%WP5398%HOMO SAPIENS NRXN1 deletion syndrome NRXN1 GRIN3A GRIA2 DLG4 NLGN1 GRIN1 GRIA3 GRIA4 GRIN2B NLGN3 GRIN3B NLGN2 NEUROINFLAMMATION%WIKIPATHWAYS_20260410%WP4919%HOMO SAPIENS Neuroinflammation NOS2 ASCC1 TLR4 FOS MTOR CHUK RELA JUN NFKBIA MAPK8 COX2 MAPK14 SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260410%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT2B1 PAPSS1 SULT1C3 SULT1A1 SULT1C2 SULT1B1 SULT6B1 SULT1A4 SULT1A2 SULT1C4 HEL-75 SULT1E1 PAPSS2 SULT2A1 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260410%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS RAB5A BCL2 SMIM40 TOMM40 BAD DERL1 PPP3CC CCS MAP3K5 HEL-S-44 MAP2K6 BAX PPP3CA BCL2L1 MAP2K2 MAPK14 TNFRSF1A TNF CASP9 CASP12 GPX1 HEL-S-2 CASP3 RAC1 SLC1A2 NEF3 NEFL NEFH APAF1 CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260410%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways VHL MAP2K5 PTEN KDM5C BHLHE41 ALDOB EFCAB3 HK3 PLOD2 ENO2 KDR STAT3 ENO3 PGM2 MTOR ENPP3 HK2 PBRM1 RAPGEF5 KCNJ2 SDSL PGBD5 LDHD FLT1 FASN SSPN ACACB ACACA ACLY BAP1 HEL-S-32 SETD2 HEL-S-30 PSPH HEL-S-133P PFKP SHMT1 AKT1S1 KSR1 EGFR CAMK1 EP300 SQSTM1 PHGDH HEL-S-51e TSC1 RHEB PSAT1 CEP290 CREBBP PFKL DEPTOR ME1 PDGFRA TSC2 RPTOR GRB10 LDHB MLST8 HIF1A HEL-S-87p PKLR ENO1 HEL-S-68p PFKM HEL-S-162eP HEL-S-49 VEGFA RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260410%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CAMK2G AGTR2 CAMK1 ATF2 CMA1 CTSG HSD3B1 STAR ATF6B ITPR2 CAMK1D CAMK1G CALM1 ATF4 PLCB2 AGTR1 CREB3L3 CREB3L4 CREB3L2 CAMK4 CALML6 CYP11A1 REN CALML3 HSD3B2 CALML4 CREB3 CAMK2D CREB5 CYP11B2 CAMK2A CYP21A2 CREB1 ATF1 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260410%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome HBEGF SDCBP CD151 HLA-DMB ITGB1 HLA-DRA CD63 LGALS3BP IGSF8 CD82 SPPL2C PRDM11 ACCS HLA-DMA CRY2 PHF21A ALKBH3 C11orf96 ALX4 TIMP1 TP53I11 SHH LARGE2 PEX16 CHST6 ITGA4 IZUMO1 SLC35C1 SYT13 NRXN1 MAPK8IP1 VANGL1 FREY1 SLC25A17 B4GAT1 GLI3 B3GNT7 PEX3 TSPAN18 LEF1 MS4A1 EXT1 B4GALT4 EXT2 ITGA6 CHST1 CD19 REST PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260410%WP4917%HOMO SAPIENS Proximal tubule transport SLC6A20 SLC4A4 SLC5A5 CLTRN CA4 ATP6V0A4 SLC3A2 ATP6V1E1 ATP6V1D SLC22A11 ABCG2 ATP6V1G1 SLC6A19 ATP6V0B SLC6A18 SLC36A2 SLC34A1 ATP1B1 HEL-76 SLC5A8 SLC7A7 SLC7A9 FXYD2 ATP6V0D2 SLC34A3 ATP6V0E1 ATP6V0C SLC22A7 ATP6V1B1 SLC22A2 SLC2A2 SLC5A1 ABCC2 ABCB1 AQP1 SLC16A10 ATP6V1F SLC1A1 SLC47A2 ATP6V1A SLC9A3 SLC22A6 SLC47A1 SLC3A1 ATP1A1 SLC5A2 ATP6V1C1 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260410%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRB RXRA RXRG RARB RARA NR1B3 IL11 SIGNALING%WIKIPATHWAYS_20260410%WP2332%HOMO SAPIENS IL11 signaling PIK3R2 PIK3R1 BCL2 SOCS3 IKBKB FYN STAT1 MAPK1 STAT3 PTPN11 HRAS MAPK3 RPS6KB1 IL11RA RUNX2 PTPA MAP2K1 MAP2K2 BIRC5 TGFB1 IBSP BGLAP FES GRB2 RPS6KA1 PDPK1 RAF1 ITGA2 IL6ST SRC JAK1 CHUK RELA IL11 RPS6 TYK2 PIAS1 CREB1 YES1 ATF1 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation GABARAPL1 RB1 RB1CC1 TNF ATG101 GABARAP ATG16L1 MAP3K5 TRAF2 PTK2B WDR45B ULK1 GABARAPL2 SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260410%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway NR3A2 HSD17B1 HSD17B2 SULT1E1 SLCO4A1 HSD3B1 SLCO1A2 HSD17B3 SLCO2B1 SLCO4C1 SLCO1B1 LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260410%WP3934%HOMO SAPIENS Leptin and adiponectin PRKAA1 LEP CPT1A ADIPOR2 PRKAB1 PRKAG1 ACACA LEPR ADIPOR1 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260410%WP4400%HOMO SAPIENS FABP4 in ovarian cancer FABP4 NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260410%WP3645%HOMO SAPIENS NAD biosynthetic pathways TNKS SIRT4 SIRT5 SIRT7 TDO2 SIRT2 SIRT3 NMNAT1 TNKS2 NAPRT PARP2 NAMPT PARP4 SIRT1 BST1 SIRT6 NADSYN1 PARP1 IDO1 HEL-S-90n RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260410%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway MMP2 CRK MYC PIK3R1 NCK1 BAD EIF4EBP1 MSH2 STAT3 PTPN11 ITGB1 PIK3CA BIRC5 CASP9 RAD51 MAPK8 PAK1 CHUK NFKBIA MAPK13 ERBB2 EGFR YAP1 GRB14 FOXO1 IKBKB IKBKG NRAS NOS2 MAPK1 ANGPT4 HRAS ANGPT2 MAPK3 ANGPT1 BAX NFKB1 MAPK14 MAPK12 GRB2 KRAS SOS1 RS1 GRB7 TNIP2 TNIP3 MAPK11 CTNNB1 RAC1 SRC PXN RELA MAPK9 STAT5B OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260410%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies BMP2 HES5 SMAD2 CSNK1A1L ZMPSTE24 FNTA ICMT CDK4 DICER1 TARBP2 CEBPA EMD HMGA2 CEBPB RUNX2 AGO2 CEBPD CREBBP GDF8 TGFB1 CTSK HDAC1 PPARG RB1 TNFRSF11B MYOD1 GSK3B SPP1 JUNB LEMD3 CTNNB1 PS1TP5BP1 WNT10B KAT2B TCF7L2 LMNA TCF7L1 CDKN1A NOTCH1 LEF1 CSNK1A1 AXIN1 WNT7B MAOA HES1 APC GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260410%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260410%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection NFATC2 NCK1 CBL FYN IL5 CDK4 CD40LG MAP3K8 CTLA4 PLCG1 PTPRC PTPN6 PIK3CA MAP3K14 GSK3B TNF PAK1 ITK CHUK PRKCQ LAT MAP3K7 IL10 NFKBIA CARD11 BCL10 IKBKB IKBKG RRAS FOS MAPK3 CD3D JUN PDCD1 MAP2K1 MAP2K2 NFKB1 CALM1 CSF2 GRB2 SOS1 RAF1 IL2 IL4 GRAP2 DAG1 CHP1 AHSA1 CD8A LCP2 ICOS IFNG MAPK9 ZAP70 LCK BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260410%WP272%HOMO SAPIENS Blood clotting cascade PLG SERPINB2 PLAT FGA HEL-S-78p F9 F11 F10 SERPINF2 F2 F3 F5 F7 F8 F13B KLNA1 KLKB1 VWF MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260410%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome HNRNPH1 GPRIN1 TET3 PTEN DLX5 BDNF DLX6 FOXG1 NREP EZH2 FUT8 PRPF38A FUS GAD1 OPRK1 POU4F1 HNRNPF TARDBP TAF1 POU3F2 SP1 NCOR1 MTOR SST IGF1R HDAC1 IGF2 IGF1 CTCF YBX1 SIN3A BCL6 CNP TET2 TET1 GRIA3 GRIA4 SP3 REST FGF7A FKBP5 NF1 MBP FGF5C GRIN1 APOC2 FGF2 SGK1 CEBPD HEL-S-20 SMC3 UBE3A MEF2C RPS6 PSIP1 CAMK2A CDON RBFOX1 CREB1 TAP1 MYT1 KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260410%WP4742%HOMO SAPIENS Ketogenesis and ketolysis BDH1 OXCT1 UCP2 CPT2 SLC25A20 ACAT1 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5365%HOMO SAPIENS 4p16 3 copy number variation FGFR3 PIK3R1 CBL NELFCD MAPK1 SLBP NSD2 PLCG1 CLTCL1 MAPK3 FAM53A NELFB NELFA CKAP5 LETM1 NICOL1 FGF2 TACC3 NAT8L GRB2 SOS1 POLN UBE2J2 FRS2 ERI1 H3F3B PPAR SIGNALING%WIKIPATHWAYS_20260410%WP3942%HOMO SAPIENS PPAR signaling LPL ANGPTL4 SLC27A1 DBI CD36 EHHADH ACSL1 PLIN1 UBC FABP1 NR1H3 NR1C1 FABP4 RXRB RXRA RXRG CYP7A1 SCD PLTP AQP7 SLC27A4 OLR1 ACOX1 HEL-S-28 APOA2 APOC3 APOA5 PPARG PDPK1 ME1 FADS2 NR1C2 PCK1 CPT1C CYP8B1 CYP27A1 UCP1 CYP4A11 SLC27A5 CPT2 PCK2 PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260410%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex NRF CD8B1 PRG3 CD2 MMP25 IGLL1 CXCL8 LBP FYN CD8A CD3G CD3E IL6 HLA-DRB5 HLA-DRA HLA-DRB1 CRP ZAP70 LCK TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260410%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals NQO1 MAF KEAP1 AIMP2 GCLC HMOX1 MAPK8 GCLM EPHB2 PRKCA CEBPB NFE2L2 SLC7A11 PIK3CA CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260410%WP2023%HOMO SAPIENS Cell differentiation expanded index KLF4 PAX7 MYOD1 EZH2 HDAC5 LEFTY1 SOX2 TLX3 ID2 TLX2 TLX1 MEF2D LEFTY2 STAT3 MEF2C MEF2B RUNX2 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260410%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein BOK MCL1 MYC BCL2 BCL2A1 GSK3B BCL2L12 BCL2L10 BCL2L2 BCL2L14 AKT3 BAK1 BAX ITGA6 ITGB4 PTHLH BCL2L1 GSK3A BCL2L13 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260410%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome CCDC6 PTEN TBX6 EZR PCNA SIAH1 REL PPARG SMEK1 DOC2A FAM57B FIMP CASP8 CCT6B SPN TRAF2 PPP4R1 PPP4R2 PPP2R1A PPP4R4 PAGR1 UNC13B UNC13A HEL-S-69 PPP2R5D PPP4R3B ASPHD1 TCP1 PPP2CA KCTD13 TRAF6 ZG16 INO80E HDAC3 MVP GDPD3 CORO1A HIRA HIRIP3 PPP4C CCT8 CCT7 CCT4 IGBP1 MLL2 HEL-S-100n C16orf54 CCT6A TAOK2 YPEL3 MAP2K6 MAPK3 MAP2K3 NFKB1 CDIPT HEL-S-90n NR3C1 PAXIP1 BPTF PARP4 HEL-S-87p KMT2C PRRT2 HEL70 G PROTEIN SIGNALING%WIKIPATHWAYS_20260410%WP35%HOMO SAPIENS G protein signaling PRKCZ PPP3CC ARHA PRKACG PRKAR1B PRKAR1A ADCY9 PDE4B PDE4A GNG10 GNG12 PDE4D GNG11 GNG13 GNAI3 GNB2 ADCY3 GNAI1 GNB3 GNB5 GNA13 GNGT1 PRKCQ GNAO1 GNGT2 GNB1 GNAS PRKD1 ADCY1 ADCY8 ADCY6 GNG3 GNG5 GNG4 NRAS RRAS GNG7 HEL159 AKAP10 ARHGEF1 GNG8 AKAP12 AKAP11 HRAS PDE8A PRKD3 AKAP9 GNAZ PDE1C PPP3CA PDE1B PDE1A AKAP7 AKAP6 AKAP5 AKAP4 GNA14 GNA15 PLCB3 AKAP8 KCNJ3 CALM1 GNAL PDE7B KRAS PDE7A PRKCH PRKCB PRKCE PRKCA PRKCI GNA11 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260410%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1CC BCL2 EIF2AK2 MAP1LC3A PPP1R14C PPP1R3A XBP1 ERN1 DDIT3 PPP1R14A HEL-S-80p PPP1R12B ATF4 PPP1R3C PPP1R12C PPP1R15A PPP1R7 PPP1R15B PPP1R13B PPP1R11 PPP1R10 PPP1R1B PPP1R9A HEL-S-89n PPP1R2 PPP1R8 MAPK8 PPP1R16B MBTPS1 PPP1R14B EIF2AK1 PPP1R16A PPP1R3G PPP1R3F PPP1R1A PPP1R3B PPP1R3E PPP1R1C PPP1R3D PPP1R14D MBTPS2 EIF2S1 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260410%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 TLR4 ATF4 CREB3L3 CD14 CREB3L4 CCL2 MAPK11 CREB3L2 IL1B CREB3 RELA NFKB2 IL6 REL IL10 RELB CREB5 NFKB1 CREB1 MAPK14 MAPK13 MAPK12 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260410%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection CAMK2G BCL2 CYCS BAD NOS2 DLG4 AKAP9 CNGA1 GUCY1A2 GUCY1B1 GRIN1 PBR PDE3A ACTN2 NFKB1 CALM1 TNF CASP9 IL1B CNGB1 RELA IFNG NEFL CAMK2D NFKBIA CAMK2A CNGA3 CNGA4 NPPB PDE2A GRIN2B CREB1 CNGB3 NPPA PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260410%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation PCSK9 LDLR SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260410%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling HTR2B MAPKAPK2 KRAS RAF1 GATA4 HTR2A NRAS MAPK1 HRAS MAPK3 RASGRF1 MAP2K1 MAP2K2 ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies FCER1A MS4A2 CRLF2 IL13RA1 IL2RG TSLP IL4 JAK3 IL5 FCER1G IL13 STAT3 OSMR IL25 TYK2 IL33 IL1RL1 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260410%WP3871%HOMO SAPIENS Valproic acid pathway IVD HADHB ABAT HDAC1 CYP2C9 EHHADH CYP2B6 HSD17B10 ACADSB CYP2A6 FERROPTOSIS%WIKIPATHWAYS_20260410%WP4313%HOMO SAPIENS Ferroptosis BACH1 STEAP3 TFRC SLC40A1 SAT2 CBS FTH1 SLC39A8 SLC11A2 SLC39A14 VDAC3 CHMP6 CTH CHMP5 IREB2 DPP4 FTMT PCBP1 LPCAT3 HMGCR MAP1LC3C FACL4 TF GCLM SLC38A1 CP CYBB FTL PHKG2 HEL-S-102 AKR1C1 ATG5 AKR1C2 SLC7A11 AIFM2 POR DKFZp762B153 SLC3A2 NOX4 CISD1 ACSL3 MAP1LC3A HMOX1 GCLC ACSL1 ACSL6 COQ2 ACSL5 ALOX15 PRNP GPX4 HEL-S-64p FDFT1 AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260410%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy MMP2 MMP9 SMAD2 HEL-S-78p PRKAA1 MCUB MCU SCX ATP2A1 TOMM20 SLN SGCA TRPC6 CAPN3 SSPN TRDN CACNB1 ITPR2 STIM1 PPIF ORAI1 CASQ1 ELANE SLC25A5 TGFB1 CACNA1F CACNG1 PRG3 CACNA1S SNTB1 SIGMAR1 FKBP1A TNF CASP9 CACNA2D1 CYBB SMAD4 IL10 TGFBR1 NFKBIA TGFBR2 IL1A TRPC3 PRKAA2 MPO PLA2G2A NOX4 NOS2 TRPC1 TNNI1 IL6 DMD RYR1 NFKB1 CTGF AGTR1 SPP1 FGA DAG1 IL1B CAMK2D KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260410%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway CSF2 GRB2 KIR2DL1 KIR2DL3 TNF FYN CD34 SYK PRKCA TYROBP LCP2 RAC1 HRAS PRKCQ PLCG1 LAT HLA-C IFNG PTPN6 VAV1 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260410%WP4963%HOMO SAPIENS p53 transcriptional gene network IRF9 BBC3 PTEN TIGAR PCNA MSH2 PRKAA1 MTOR PRKAB2 PRKAB1 TNFRSF10B TP53AIP1 ADORA2B ULK2 ULK1 ZMAT3 TRAF4 PERP SESN1 SESN2 DDIT4 SMR3B ACAD11 NCF2 TNF SERPINB5 SCO2 ADGRB1 PML PRKAG1 XPC PRKAG2 CPT1C AURKA DRAM1 E2F7 RPRM SIVA1 PRKAG3 TP53INP1 MGMT XRCC5 CX3CL1 FUCA1 FANCC TNFRSF10D CDKN1A TP53I3 ULBP2 BTG2 AKT1S1 ULBP1 LIF APAF1 SLC7A11 RRM2B PRKAA2 TNFSF6 ISG15 GADD45A FAS CCNG1 SFN CCL2 CCNE1 THBS1 BAX CDK2 DEPTOR PMAIP1 TSC2 GPX1 RPTOR POLK MLST8 GLS2 PIDD1 NOTCH1 DDB2 ERCC5 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis UGT1A10 HSD11B1 UGT2B7 HSD11B2 SRD5A2 CYP11B2 CYP21A2 AKR1C1 AKR1C2 AKR1C4 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260410%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain AMOT MAP2K5 RAF1 YAP1 TRIO ARHA MAPK1 MTOR RAC1 MAP2K6 MAPK3 MAP2K3 MAP2K4 MAP2K1 MAP2K2 NFKB1 PIK3CA SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260410%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response CXCL17 IFNAR1 ACE2 MAVS CXCL12 CXCL6 RIGI CXCL13 STAT1 STAT2 TRIM25 IL8RB TRAF5 CXCL1 TGFB1 CXCL5 HDAC2 PPBP TNF CXCL11 TRADD CASP8 CXCL9 TBK1 TRAF2 CXCL3 IFNB1 FADD TP53I3 IFITM1 IL10 CXCL2 IFIT2 AP1G1 DHX58 IRF3 HAVCR2 TRAF3 TLR7 LAG3 TRAF6 hEMMPRIN IRF7 TANK NUP98 CD160 LARP1 RAE1 MX1 EP300 CXCL8 CCL5 CCL4 CCL2 CCL3 IL6 NFKB1 IL6R PF4 RIPK1 CSF2 TFAP2A JAK1 IFNAR2 TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260410%WP1471%HOMO SAPIENS Target of rapamycin signaling PRKAA2 MAPKAP1 RRAGA DDIT4L RRAGB RRAGD CDC42 EIF4EBP1 PRKAA1 TSC1 MTOR PRKAB2 RPS6KB1 HMGCR PRKAB1 RHEB ULK2 ULK1 DDIT4 FKBP1A TSC2 PRKAG1 PRKAG2 IDI1 RPTOR PRKCA PRKAG3 MLST8 RAC1 AKT1S1 RICTOR PRR5 APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260410%WP1772%HOMO SAPIENS Apoptosis modulation and signaling BBC3 MCL1 BLK BAD BCL2L11 TNFRSF10A TNFRSF10B BIRC5 IL1R1 BIRC7 BIRC2 MAP3K14 BIRC3 BCL2A1 BCL2L10 TRADD BCL2L2 CASP9 MAPK8 CASP8 CASP6 IL1R2 CASP10 IRAK1 CASP3 TNFRSF10D FADD SEPTIN4 DFFB NFKBIA DFFA MADD PRKD1 APAF1 TRAF3 AIFM2 TRAF6 TNFSF6 MYD88 HRK BCL2 TNFRSF6B FAS CAPNS1 CYCS CASP4 SMIM40 PTRH2 TNFRSF25 IKBKB TNFRSF1B NAIP BAG3 BMF BAK1 MAP3K5 BIK TNFRSF10C PTPN13 FOS CDKN2A MAPK3 BNIP3 BAX JUN BCL2L1 NFKB1 TNFRSF1A AIFM1 TNFSF10 CASP2 BOK RIPK1 PMAIP1 PIDD1 DIABLO CRADD HTRA2 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260410%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PTPN11 CTLA4 PIK3R2 CD80 PIK3R1 PTPN6 PIK3R3 HLA-DRB1 PPP2CA PIK3CD PIK3CA GPCRS OTHER%WIKIPATHWAYS_20260410%WP117%HOMO SAPIENS GPCRs other CHRM3 OR2F1 GPR55 EMR3 ADGRD1 GPR143 OR2A5 LGR6 CHRM2 OR2A4 ADGRL2 GPR18 F2R HTR1F ADGRL3 OR7E24 IL8RB CCR5 SMO HTR2A CXCR1 SSTR2 EDNRA FSHR CCR2 UTS2R CNR1 CCKBR CXCR3 OR1G1 OR2M4 GPR61 GPR62 GRPR CELSR2 CELSR3 RXFP3 ADGRE2 GPR176 HTR7 GPR132 ADORA2A ADRA1D GNRHR GPR135 ADGRV1 ADRB2 S1PR1 ALG6 OR1F1 OR2H1 TAAR5 GPR183 OR1J2 TAAR2 OR1N1 GPR162 OR5AC2 ADGRF5 VN1R1 OR10A2 OR6C3 DRD3 OR3A3 OR6C2 DRD4 OR10A5 OR3A1 OR8G1 CELSR1 PTGFR OR1E1 C5AR2 GPR88 GPR83 GPR84 MCHR2 GHRHR FY OR2B6 NTSR1 OR5D3 P2RY13 GPR17 P2RY11 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260410%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 CBFB ELOC RBX1 UBA3 NAE1 T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260410%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling CD8B1 CALM1 PTEN NFATC2 GSK3B IL2 FYN DYRK2 ITK DYRK1A PRKCA CD8A CTLA4 PLCG1 PTPN6 CSNK1A1 PPP3CA PDCD1 NFKBIA GSK3A ZAP70 NFKB1 LCK SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260410%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MYOCD NKX2-5 MEF2C KLF4 CAMK2D MEF2B CCND2 MEF2D LEPTIN SIGNALING%WIKIPATHWAYS_20260410%WP2034%HOMO SAPIENS Leptin signaling PTEN PIK3R2 ROCK1 PIK3R1 SOCS3 BAD CDC42 EIF4EBP1 FYN EIF4E PLCG2 STAT1 ARHA SP1 PRKAA1 STAT3 CFL2 PTPN11 KPNA4 MTOR KHDRBS1 PLCG1 SOCS2 RPS6KB1 CISH SOCS7 REL PDE3B ACACB ACACA LEP RPS6KA1 GSK3B MAPK8 CHUK GSK3A ERBB2 PRKAA2 ROCK2 SH2B1 FOXO1 IKBKB IKBKG NCOA1 MAPK1 HRAS MAPK3 MAP2K1 MAP2K2 LEPR NFKB1 MAPK14 PTPN1 GRB2 SOS1 RAF1 IRS1 RAC1 SRC JAK1 RELA RPS6 STAT5B CREB1 AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PIK3R4 MAPKAP1 PIK3R2 PIK3C2G PIK3R1 PIK3C2A PIK3C2B FOXO1 IKBKG TSC1 MTOR SIRT1 PHLPP1 PIK3R3 PIK3R5 STK11 PIK3CA ATM GSK3B PARP2 TSC2 AKT3 PIK3CD RPTOR PARP3 MLST8 RICTOR PARP1 TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260410%WP325%HOMO SAPIENS Triacylglyceride synthesis DGAT1 LPL PLPP2 PLPP1 DGAT2 LIPE GPAM PNPLA2 GNPAT GPD1 AGPAT5 AGPS MOGAT3 MOGAT2 LIPC MOGAT1 AGPAT3 AGPAT4 LIPF PLPP3 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260410%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer CCDC6 CDK6 MYC BARD1 CDC2 CDC25B PCNA MSH6 SAP30 CDK4 PRMT2 HMGB1 TOP2A ORC1L CCND3 HMGB2 SMC2 HDAC1 RB1 TFDP1 TFDP2 PRKDC E2F2 FAF1 TTK E2F3 NPAT CCNB2 CCND1 HLTF RBBP7 SIN3A RBP1 PLK4 CDT1 FANCG POLA1 ZNF655 RRM2 MCM7 CDKN1A SKP2 MAPK13 RRM1 DHFR RBBP4 RPA3 CHEK1 MCM3 RPA1 MCM6 TYMS CCNE1 CDK2 MDM2 PRIM1 CCNE2 CDC45 RAF1 SMC3 POLD3 SMC1A CDKN1B POLE SUV39H1 RFC3 RFC4 CCNA2 CCNB1 H2AZ1 POLE2 WEE1 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260410%WP4925%HOMO SAPIENS Unfolded protein response CASP2 BBC3 ATF4 PPP1R15A BCL2 PMAIP1 HEL-S-89n MBTPS1 XBP1 RTCB BCL2L11 TXNIP IL1B ERN1 TNFRSF10B DDIT3 MBTPS2 NFE2L2 EIF2S1 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260410%WP404%HOMO SAPIENS Nucleotide metabolism RRM2B HPRT1 DHFR POLG POLA1 RRM2 ADSL NME2 OAZ1 SRM IMPDH1 ADSS MTHFD2 RRM1 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260410%WP5136%HOMO SAPIENS ALA oxylipin metabolism EPHX2 ALOX5 ALOX15 MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260410%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system NDUFB9 ECSIT NDUFA12 TMEM186 C3orf60 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS3 ND1 NDUFS1 TMEM126B ND2 ND5 ND4 ND6 NDUFB8 NDUFB7 DMAC1 NDUFB10 NDUFB6 NDUFB5 NDUFB11 DMAC2 NDUFB4 NDUFB3 NDUFB2 NDUFB1 TMEM70 NDUFV3 NDUFV2 NDUFA7 TIMMDC1 COA1 NDUFA6 ZNF183 NUBPL NDUFA3 NDUFA2 ND4L NDUFAF6 NDUFA5 NDUFAF4 NDUFAB1 ACAD9 NDUFA13 NDUFAF2 NDUFAF1 NDUFA10 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260410%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism CALCA IL3 BHLHE41 MTOR CTF1 SMAD1 ULK1 NR1D2 SMAD9 TGFB1 HMGB1 NFATC1 LEP DKFZp781O1323 RB1CC1 IGF1 NPAS2 EFNB2 SMAD4 TNFRSF11A ATG5 TRAF6 BMP4 BMP2 PRKAA2 DKFZp762B153 ATG3 SQSTM1 BCL2 BHLHB2 ATG10 AMBRA1 BMPR2 ATG12 MAP1LC3A SOST CTHRC1 ATG16L1 BMP3 SEMA3A IL6 WNT16 DKK1 RUNX2 CRY1 LRP5 PER1 CTSK PTH CSF1 RORB TNFSF11 ARHGAP4 TNFRSF11B FYCO1 LAMP2 VCP ATG101 DRAM2 SEMA4D PLEKHM1 SP7 BMP6 WNT10B NOTCH1 BMP5 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260410%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome FEZ2 SNURF NUP54 CDK6 NUP58 DLX5 BDNF OCA2 NUP205 SLC45A2 MAGEL2 CDKN2B SEH1L PRKCZ LHB INS ATP10A AAAS NUP160 NHLH2 EIF4E NUP42 MDM4 NUP85 CDK4 RANBP2 CDKN2C NUP155 TPR NUP153 CDC6 NUP35 MKRN3 GNRH1 CYFIP1 FMR1 NUP88 TUBGCP5 NIPA1 MSX1 TUBGCP6 GABRB3 POM121 TUBGCP4 NIPA2 RB1 CCND1 GABRA5 OXT GABRG3 GABRG2 GABRG1 CGA KISS1 NGF HEL-S-71 GHRH GHRL TYR NUP98 RAE1 NUP133 PCSK1 CCND2 POMC NDN HERC2 CDKN2A MDM2 BBS4 RNF8 UBE3A AHCTF1 NUP107 NUP188 NPAP1 GABRR3 PCM1 GABRR1 NUP62 NUP214 NDC1 GOLGA8S SNRPN NUP210 FSHB GOLGA6L2 TACR3 NUP93 FEZ1 BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260410%WP5548%HOMO SAPIENS Blood based neuroinflammation markers CCL11 BDNF DBI TNF CCL5 TREM2 CCL2 TREM1 CHI3L1 CX3CL1 IL1B IL6 GRN NEFL ADM PBR S100B CRP CCL23 GFAP OLR1 RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260410%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex CDK8 MED1 TAF1 MED15 NELFB NELFA GTF2B MED19 MED14 CCNC MED16 TAF5 MED18 MED17 MED12 MED11 MED13 MED10 MED8 MED9 MED4 GTF2F1 MED27 MED26 MED6 MED29 MED28 MED23 MED22 MED25 MED24 MED21 GTF2A1 CTDP1 TAF9 GTF2E2 POLR2A THRA MED30 POLR2B MED31 POLR2D POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POLR2M TAF12 TAF13 TAF10 TAF11 TRFP TAF8 NELFCD TAF7 TAF6 CRSP9 TAF4 TAF3 POLR2C TBP METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260410%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway TXN MTR MAT1A AMD1 APIP MRI1 IL4I1 MSRA MTAP ADI1 SMS SRM MSRB2 MSRB3 ENOPH1 HEL-S-61p CHDH DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260410%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens SESN2 ATF4 MYC FOXO1 TSC2 IRS1 PHB2 TSC1 SLC7A7 MTOR MARS1 GDF15 OMA1 HSPD1 CLPP LONP1 LONP2 EIF2A PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP4784%HOMO SAPIENS Proteoglycan biosynthesis SLC35B2 XYLT2 CANT1 SLC26A2 BPNT2 B3GALT6 XYLT1 CHSY1 CHST14 CSGALNACT1 B3GAT3 PAPSS2 EXT1 EXT2 CHST3 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260410%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 TLR4 MYD88 IKBKB IKBKG MAPK1 NFKB2 REL NFKB1 TICAM2 TLR3 TBK1 IRAK1 IKBKE CHUK RELA IRAK4 TICAM1 TLR1 RELB TIRAP TLR9 TLR8 IRF3 TRAF3 TLR7 TRAF6 IRF7 TLR5 ZINC HOMEOSTASIS%WIKIPATHWAYS_20260410%WP3529%HOMO SAPIENS Zinc homeostasis SLC39A8 SLC39A14 MT1M SLC30A10 MT2A SLC39A9 SLC39A6 SLC39A5 SLC39A2 SLC39A1 SLC39A3 SLC30A7 SLC30A6 SLC30A9 SLC30A8 SLC30A2 SLC30A5 SLC30A4 SLC39A11 SLC39A10 SLC39A13 SLC30A1 SLC39A12 MT4 MT3 MT1A MTF1 MT1F MT1G MT1B MT1E VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260410%WP1533%HOMO SAPIENS Vitamin B12 metabolism PLG MCEE SCARB1 MPO CBS APOE APOB INS LDLR CCL5 ABCA1 HEL-S-78p CCL2 INSR HEL-S-51e CTH HEL-S-44 ALB SAA1 SAA2 NFKB2 IL6 CUBN CRP NFKB1 SERPINA3 HBB MTRR MTR PLAT TNF MAT1A TCN2 CBLIF FGA TCN1 HBA2 IL1B RELA F2 F7 IFNG SAA4 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260410%WP5399%HOMO SAPIENS NPHP1 deletion syndrome RPGRIP1L NPHP1 MAPK1 MAPK3 FLNA PTK2B FLNB INVS BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260410%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation BMP2 TOB1 SMURF1 SMAD6 TOB2 SMAD4 SMAD1 NOG RUNX2 BMPR2 BMPR1A ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260410%WP1993%HOMO SAPIENS Angiogenesis overview MMP2 CRK VHL MMP9 MMP14 ROBO4 SHB NCK1 TIMP4 BMX BAD CDC42 PLXND1 KDR PTPN11 MTOR PLCG1 FGFR1 PDPK1 MAPK8 PAK1 FRS2 MAP3K7 APC WAS ATF2 NOX4 NRP1 GRB14 ROBO1 MAPK1 MAP2K6 SEMA3A ANGPT1 MAP2K4 MAP2K1 SLIT2 MAPK14 GRB2 KRAS SOS1 RAF1 GRB7 PIK3CD MAPK11 DAG1 PRKCA RAC1 SRC PXN F2 PTK2B IQGAP1 PLA2G1B VEGFA NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260410%WP288%HOMO SAPIENS Nod like receptor NLR signaling CD40 CHUK RELA MAP3K7 IKBKB ERBIN MAPK8 IKBKG EPHB2 HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling CRK MET PTEN RAP1A PTGS2 MAPK1 STAT3 PTPN11 FOS HRAS MAPK3 ITGB1 JUN MAP2K1 MAP2K2 PIK3CA GRB2 DOCK1 SOS1 RAF1 MAPK8 CRKL PAK1 ITGA1 SRC PXN HGF PTK2B MAP4K1 RAPGEF1 VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260410%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms RXRA RARA NR1i1 OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260410%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development BMP7 KLF4 DMP1 DSPP SOST SP7 NOTCH2 NOTCH3 CTNNB1 ALPL HNF1A NOTCH1 DKK1 RUNX2 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260410%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult LMO2 HBZ HBA2 HBG2 HBG1 HBB HBE1 HBD tal-1 GATA1 LDB1 NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling EGFR TLN1 NRAS MAPK1 HRAS COL1A1 ITGB1 MAP2K1 MAP2K2 MAPK14 MAPK12 MAPK10 GRB2 KRAS SOS1 RAF1 AKT3 PIK3CD MAPK8 MAPK11 AREG ITGA1 SRC PXN MAPK9 MAPK13 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260410%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation PIK3R2 PIK3R1 ARHH SOCS1 DGKA TMEM222 ARIH2 UBASH3A MAP3K8 DGKZ RASA2 RNF7 RPRD1B PLCG1 SH2B3 SH2D1A REL FIBP PTPN6 CD5 AGO1 MAP3K14 PDPK1 TNFAIP3 ITK GNA13 CHUK PRKCQ LAT MAP4K1 NFKBIA CARD11 BCL10 TRAF6 IKBKB IKBKG NDUFB10 MEF2D CD3G CD3E CD3D NFKB1 GRB2 CDKN1B CUL5 GRAP2 CD8A LCP2 RELA VAV1 ZAP70 LCK OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260410%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid CYP4A11 CYP2C9 CYP2C8 PTGS2 ALOX15 EPHX3 ALOX12B CYP2C19 ALOXE3 PTGS1 GPX4 CYP3A4 DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260410%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein AGTR2 ACE2 AGTR1 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260410%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation ACADL EHHADH ACSL3 ACSL1 CPT2 SLC25A20 CPT1A ACADM PECR FACL4 ACADVL ACSF2 ACADS CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260410%WP530%HOMO SAPIENS Cytokines and inflammatory response IL1A IL3 IL5 IL15 IL13 IL6 HLA-DRA HLA-DRB1 CXCL1 TGFB1 CSF3 CSF2 CSF1 IL2 PDGFA TNF IL4 IL7 IL1B IL12B IFNB1 IL11 IFNG IL10 CXCL2 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260410%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells SMAD2 CALCA BAK1 MAP3K5 MAPK1 MTOR MCU BAX PDE1B PPP3R1 BRAF TNFRSF1A PIK3CA FFAR3 TGFB1 SEC16B HEL-S-41 ACTA2 TRPV5 PTH TNFSF11 RAF1 CASP9 CASP8 CASP3 SMAD4 TGFBR1 APAF1 SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation BLM PTEN MYC CDC2 IRF8 IFT27 MAEA PRKAA1 NR1H3 CLUAP1 ARMC8 PARD3 PRKAB1 COPS7A ULK1 G6PC1 CARM1 WWTR1 CRY2 MED9 COPS4 COPS6 IFT22 COPS5 PRKAG2 TNFSF13 PARD6B BCL6 RAB8A YAP1 FOXA1 APP WDR26 JUN CRY1 PPP1R14A NR1H2 RMND5A PER1 MKLN1 GID4 PCK1 RPTOR HES6 PRKCI MLST8 IL1B ETV5 CREB1 RRAGA ROCK1 ARHA STAT3 CFL2 BCL2L11 COPS8 MTOR FOXA2 ITPK1 MAP3K14 BIRC2 FHOD1 PRDM1 FERD3L ALKBH5 RB1CC1 DENR PEMT TNF MIGA1 RNF41 TOM1L2 LLGL1 DRC5 DRC7 HEL-S-133P DRC8 FLII GPR85 CLEC16A GRIP1 SHMT1 PLD6 RAI1 RAB39B DRC1 CLTC GDI2 CLTB WDR41 CLTA ATPAF2 ARG2 RMI2 DRC10 TFEB MYH2 TLR4 PARK2 MYD88 TACI SMCR8 C9orf72 GPS1 MIEF2 RASD1 NT5M FNIP1 RANBP9 FNIP2 LIMK1 IFT56 MYO16 RAB10 MYO15A DRG2 TRAF3IP1 IFT172 IFT52 IFT46 FLCN IFT70B RMI1 TOP3A BAX IFT57 NFKB1 IFT20 IFT80 ATG101 IFT25 IFT81 RELA IFT74 MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260410%WP129%HOMO SAPIENS Matrix metalloproteinases MMP2 MMP9 MMP14 TIMP4 TCF20 MMP21 MMP20 MMP24 MMP27 MMP26 MMP28 MMP10 MMP11 MMP16 MMP15 MMP17 MMP19 MMP25 TIMP3 MMP23B TNF TIMP1 MMP3 MMP12 MMP7 hEMMPRIN ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260410%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids ABCC3 FABP6 ABCC2 ABCB1 SLC10A2 SLC51A SLC51B ABCB11 SLCO1B1 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260410%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells HNRNPH1 RAB5C RAB5A RAB5B KRAS RAF1 ARAF NRAS RRAS RAB27A MAPK1 HRAS HGS MAPK3 PDCD6IP RRAS2 BRAF EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260410%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC2H1 RHOT1 KIF1B RABAC1 SNCA RAB7A DCTN1 SYPL1 ATAT1 DYNC2I2 CASP8 DYNC1I1 DYNC1H1 MAP2 CASP3 DYNC1LI2 BAX MFN2 RAB3B TRAK1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260410%WP2571%HOMO SAPIENS Polycystic kidney disease pathway MYC PLCG2 PRKACG KDR PRKAA1 MTOR PRKAB2 PRKAB1 FLT1 STK11 IGF1R RPS6KA1 GSK3B IGF1 TNF GNAI3 KCNN4 CCND1 PRKAG1 GNAI1 PRKAG2 PRKAG3 SSTR2 WNT3A GNAS SLC12A2 ERBB2 PRKAA2 WNT2B FZD10 ADCY6 IKBKB NRAS WNT5B TSC1 PKD1 FOS HRAS MAPK3 VEGFB EGF WNT16 RHEB JUN CFTR PDE1A SFRP4 MAP2K2 BRAF KRAS DVL1 TSC2 DVL2 DVL3 FZD4 WNT1 WNT3 FZD1 CTNNB1 WNT10B SRC WNT10A WNT9B FZD3 WNT9A FZD2 FZD5 WNT4 WNT8A WNT7B WNT8B FZD7 FZD9 WNT7A GNA11 FZD8 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260410%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity NR1I3 CYP2E1 CYP2C9 CYP2B6 ABCA1 NR1B3 CYP27B1 NR1i1 NR1i2 CYP26A1 CYP24A1 NR1H3 NR1C1 CYP7A1 ABCG5 ABCC3 ABCC2 ABCB1 ABCD3 ABCD2 PPARG ABCB4 CYP4B1 ABCG1 ABCB11 RARA NR1C2 CYP8B1 CYP4A11 NR1H4 RARB CYP3A4 GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260410%WP334%HOMO SAPIENS GPCRs class B secretin like CALCRL GLP1R ADGRL2 VIPR2 GIPR GCGR ADGRL3 SCTR GPR64 CRHR1 PTH2R CRHR2 CALCR ADGRE5 ADGRL4 ADGRL1 ADCYAP1R1 GHRHR ADGRE2 PTH1R MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260410%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors MSMP CTCF CCR2 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260410%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma NOTUM MYC CSNK1A1L EZH2 CCND3 GSK3B CCND1 WNT3A AXIN1 DKK4 APC ELAVL1 WNT2B CHD8 FZD10 FRAT1 FRAT2 CCND2 SOX17 SOST CER1 WNT5B CSNK2A1 CSNK2A3 CSNK2A2 CTNNBIP1 KREMEN1 CSNK1E WNT16 SENP2 DKK1 JUN SOX7 DKK2 SFRP4 SFRP1 SFRP5 PORCN CSNK2B ROR1 LRP5 ROR2 LRP6 CTBP2 CTBP1 NLK CXXC4 KLF4 NKD1 NKD2 WIF1 DVL1 DVL2 DVL3 WNT1 WNT3 FZD1 CTNNB1 WNT10B TCF7L2 MTDH WNT10A FZD3 TCF7L1 FZD2 LEF1 FZD5 WNT4 CSNK1A1 RYK WNT7B FZD7 FZD9 WNT7A FZD8 FOSL1 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260410%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation HEL-S-21 ND1 COA3 AS3MT UQCRFS1 SDHA HEL-S-44 ATP1A1 ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260410%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis 5HT1A FAAH KCNQ2 TRPA1 KCNQ3 PTGS2 CACNA1H PTGS1 TRPV1 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260410%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits VHL TCF7L2 VCAM1 SRC TCF7L1 NOTCH1 LEF1 CXCR4 POSTN TNC CYTIP VEGFA 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome ERBB2 COX11 CNNM3 CNNM4 COL2A1 FER1L5 STARD7 CIAO2B SEMA4C ANKRD23 DUSP2 ARID5A ASTL NEURL3 KANSL3 PLXNB2 ZP2 MMS19 SNRNP200 ADRA2B ARHA MAPK1 MAPK3 CIAO2A ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 GLUCURONIDATION%WIKIPATHWAYS_20260410%WP698%HOMO SAPIENS Glucuronidation UGT1A3 UGT1A1 UGT1A10 UGT1A9 UGT2B10 UGT2B11 UGT2B15 UGDH UGT2B17 UGT2B28 UGT1A8 PGM3 UGT1A5 PGM2 UGT2B4 UGT2A2 UGT1A7 PGM5 UGT2A1 UGT2B7 UGT1A4 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260410%WP550%HOMO SAPIENS Biogenic amine synthesis ACHE PAH PNMT AANAT HDC GAD1 ChAT TPH1 GAD2 ASMT DBH DDC TH MAOA PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260410%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation PTGS2 EDN1 ANXA2 PTGER4 PTGER1 PTGER2 PTGER3 PTGIS TBXA2R ANXA6 PTGS1 PTGFRN HEL-S-7 AKR1B1 S100A10 PTGIR ANXA3 ANXA4 SCGB1A1 S100A6 PTGES PPARG HPGD PPARGC1A PPARGC1B CYP11A1 PTGFR SOX9 PTGDR PRL EDNRA EDNRB HSD11B1 HSD11B2 ANXA1 AKR1C1 AKR1C2 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260410%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling PTEN EPOR PIK3C2A PIK3C2B KDR RAB2A ULK1 EPHA2 PDGFD PIK3CA PDGFC NGFR TCL1B PPP2R1B PELO IGF1 HIF3A STRADA PHLPP2 COL11A2 CSHL1 GHB3 PFKFB1 PFKFB4 ITGAE PPP2R5E ITGAX FGF8A PPP2R5B PPP2R5A PPP2R3C CDKN1A PPP2R3A PIK3IP1 PPP2R2C PPP2R2B PPP2R2D PPP2CA RAB8A FGF7B FGF7A ELAVL1 GYS1 KIT FGF18 FGFR3 ATF2 FGF6B FOXO1 IKBKB IKBKG NOS2 TSC1 VEGFB FOXA1 FGF5C VEGFC RHEB VEGFD THBS1 MDM2 FGF2 CSF3 ATF4 FGF7 CSF1 FGF8 EPO RAB14 ITGB3 ITGA2B PDGFRA TSC2 COL4A2 COL4A1 COL4A4 COL4A6 CSF1R EFNA5 EFNA4 FGF20 FGF22 XB EFNA1 EFNA3 FGF14 KITLG EFNA2 FGFR4 FGF13 FGF12 PHLPP1 FGF10 FGFR1 ITGB1 FLT1 ITGB4 ACACA CRTC2 STK11 FLT4 LAMC2 DDIT4 LAMC1 TCL1A PPARGC1A ITGAM ITGAV ITGA4 ITGA2 NGF IFNB1 AKT1S1 ITGA6 LAMA5 PRKAA2 COL2A1 LAMA1 LAMA4 LAMA3 SLC2A3 LIPE PRLR ANGPT4 THBS2 ANGPT2 COL1A1 LAMB3 COL3A1 ANGPT1 EGF LAMB2 LAMB1 RPS6KB2 CDKN1B SPP1 JAK3 OSMR HIF1A TNC OSM VEGFA COMP TNR CHRM2 BAD VTN CHAD PRKAA1 FOXO3A COL1A2 COL5A3 COL5A2 ITGB5 ITGB8 ATF6B PIK3R5 ITGB7 ITGB6 GNG10 VWF ITGA7 IGF1R THBS4 GNG12 PDPK1 THBS3 GNG11 RELN PPP2R5C GNG13 GNB2 GNB4 GNB3 GNG2 GNGT1 GNGT2 GNB1 EGFR FGF21 EIF4E1B GNG3 GNG5 CDC37 GNG4 NRAS GNG7 MAPK1 GNG8 HRAS SLC2A4 MAPK3 MAP2K1 GYS2 MAP2K2 SLC2A2 HEL-S-125m KPG_010 IBSP GRB2 GHR KRAS SOS1 RAF1 CREB3L3 CREB3L4 CAB39 IRS1 CREB3L2 PIK3CD RPTOR PFKFB2 MLST8 JAK1 RAB11B IFNAR2 CREB3 RPS6 CREB5 CREB1 CHRM1 PIK3R4 CSF3R IFNAR1 PIK3R2 PIK3R1 INS F2R EIF4EBP1 INSR EIF4E EIF4B MTOR RPS6KB1 HSP90AB1 FGF16 IL3RA IL2RG GSK3B PDGFA AKT3 CASP9 IL2RA IL2RB PPP2R1A HGF PPP2R5D LPAR1 LPAR2 LPAR3 LPAR4 MET IFNA7 IRS4 RAB10 IL6R IL2 IL7R FGF9 PRL FGFR2 PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260410%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases RRM2B DPYS DPYD HEL74 ABAT UMPS TYMP DHODH RRM2 GLS2 TYMS OTC AGXT2 CAD NT5C3A RRM1 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260410%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy LITAF GDAP1 KIF1B MTMR2 SH3TC2 RABAC1 RAB25 EGR2 MPZ RAB7A PMP22 SBF2 FGD4 RAB4A RAB11A RAB11B NEFL HEL-S-102 MFN2 FIG4 LRSAM1 RAB3B RAB4B HSPB8 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260410%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex MCL1 PTEN ATM BCL2 EP300 ZFX GABPB1 TERF2 FOXO3A SMAD4 SMARCA4 GABPA BCL2L1 FLT3 DNMT3B ETV6 CREBBP PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260410%WP3527%HOMO SAPIENS Pre implantation embryo FOXQ1 MYBL1 SOX2 BATF3 FOSB DLX2 DDIT3 TFAP2B ZFP36 HMGA1 SMARCA4 TEAD4 POU5F1 ATP1A1 ELAVL1 E2F5 NANOGNB AQP9 DNMT3L NR3C2 KHSRP SIX3 FOXD1 SOX11 ZAR1 ARGFX DPPA3 ZFP42 PADI6 BARX2 ZFP36L2 LEUTX MTA3 CDX2 IRX5 TPRX1 HNRNPAB TBX3 MOS DPRX ZSCAN4 GATA3 MXD1 MACROH2A2 ESRRA KLF4 AQP3 IRF4 NKX2-1 PBX1 SOX8 TCF7L1 GATA2 EGR1 COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260410%WP5145%HOMO SAPIENS COVID 19 structural coverage map UPF2 AQR ISG15 IGHMBP2 MACROH2A2 PARP14 GDAP2 ACE2 NLRP12 MACROD1 TOMM70 NRP1 HEL97 MACROD2 SLC6A19 CMTR1 PAIP1 PALS1 UBB UBC MAP3K7IP1 MACROH2A1 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260410%WP500%HOMO SAPIENS Glycogen synthesis and degradation GYS1 HK3 HK2 PTPA GYS2 PYGL GYG1 CALM1 PPP2R1B PPP2R5C GSK3B PYGB PPP2R2A PYGM AGL PPP2R5E PPP2R3B PHKB PPP2R5B PHKA1 PPP2R1A PPP2R5A PHKA2 PHKG2 PPP2R3A PPP2R2C PPP2R5D PPP2R2B GSK3A PPP2CA SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260410%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 KDR ACE2 NRP1 FURIN VEGFA COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260410%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity ATP11A PLSCR3 PLSCR4 TYRO3 SERPING1 MASP1 CD46 LLGL2 CRB2 PRKCZ PLSCR1 COLEC12 CRB1 ATP10A COLEC10 VTN C4A C1S CFH C1R CFI PARD6G CFP CD59 DEDD MARK1 PARD3 ATP8B3 MERTK PROS1 C4B_2 TGFB1 ATP8B1 C1QB C1QA ITGAM SCRIB ITGAV CASP9 CASP8 CASP10 ITGAX CX3CL1 CASP3 PARD6B C1QC CR2 APAF1 CX3CR1 MFGE8 TNFSF6 FAS CYCS CAP1 CFD BAK1 C2 MBP CD55 PARD6A BAX ITGB3 PALS1 ATP8B2 PRKCI AXL C5AR2 FCN1 FCN2 PATJ COLEC11 FCN3 IFNG DIABLO C6 C4BPA C7 C4BPB HTRA2 HEL-S-62p CLU C9 C8G C5AR1 C3AR1 DLGAP5 MBL2 MASP2 C8A CR1 ATP11C ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260410%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway TGFB1 ACTA2 ACE2 AGTR1 RAF1 NOX4 MGRA RRAS SP1 MAPK1 PTPN11 IL6ST COL1A1 COL1A2 MAP2K6 SMAD4 HIF1A IL11 IL11RA TGFBR1 TGFBR2 JUND CTGF PDGFD CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260410%WP3594%HOMO SAPIENS Circadian rhythm genes PPP1CC PTEN EZH2 KCNMA1 MAGEL2 ID2 BHLHE41 CDK4 PRKAA1 BTRC NR1H3 NR1C1 TPH2 TPH1 NR1D2 PER2 DDX5 NGFR CRY2 RPS27A SIN3A AVP FBXW11 SLC9A3 AHR ROCK2 EP300 ADCY1 SIX3 HOMER1 NOS2 RORC SIRT1 IL6 DBP TYMS JUN CRY1 NFIL3 NR1D1 PER1 HEL-S-80p MAPK10 ATF4 NKX2-1 NAMPT CPT1A F7 TCF2 CREB1 CHRM1 DYRK1A UBC GFPT1 NCOR1 OGT C1orf51 PHLPP1 PROK2 AgRP PROK1 KCNH7 USP2 METTL3 SOX14 CARTPT CLDN4 SIK1 PSPC1 LEP TIMELESS TOP2A ATF5 CREM KMT2A HDAC2 MAGED1 PPARG HDAC1 OPN4 PRKDC OPN3 PPARGC1A NONO GSK3B NR2F6 NLGN1 SETX NPY2R ID4 PML HNRNPD NPAS2 FBXL3 MAPK8 KDM5A NPS SUV39H2 HEBP1 HEL-S-2 DRD1 RBM4 CRTC1 KLF10 CSNK1D KCND2 RAI1 BTBD9 SFTPC PAX4 HCRTR2 PROX1 HCRTR1 TNFRSF11A MC3R HS3ST2 PER3 SKP1 MTNR1B THRAP3 CIPC RELB GHRH CRH DDC RBM4B TH ATOH7 GHRL PROKR1 ADA NOCT CAVIN3 PASD1 UTS2R HDAC3 BMAL2 PRKAA2 UTS2 BHLHB2 AANAT FAS MTNR1A ID3 NTRK3 KLF9 NTRK1 CCAR2 CSNK1E STAR MTTP ARNT2 HTR7 ADORA2A RORA ZFHX3 SFPQ CHRNB2 RORB UBE3A DRD2 DRD3 DRD4 SUV39H1 MAPK9 PRF1 EGR1 CRX JUND MYBBP1A GNA11 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP5094%HOMO SAPIENS Orexin receptor pathway VHL PIK3R2 PIK3R1 PRKCZ LHB EIF4EBP1 OPRK1 EIF4B PRKAA1 STAT3 PTPN11 MTOR RPS6KB1 SMAD1 GNRH1 BMP7 LEP RPS6KA1 DKFZp781O1323 PDPK1 TNF CASP9 GNAI1 ARRB2 MAPK8 CGA CASP3 SLC1A2 HCRTR2 HCRTR1 GNAS IL10 CXCL2 TH GHRL PRKD1 NPFFR1 DAGLA NPY NPVF DYNLT3 HCRT GCG CXCL8 CCK NOX4 MAPK7 FOXO1 IL9 POMC DYNLT1 CAMKK2 MAPK1 SLC2A4 MAPK3 IL6 STAR RUNX2 MAP2K1 MAP2K2 SGK1 NFE2L2 MAPK14 BGLAP IL4 PRKCB PRKCE PRKCA GH1 IL1B HIF1A RPS6 MAPK9 FSHB CREB1 GNA11 BMPR1A 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome IL36A IL36B SOCS3 IL36RN SOCS1 IL36G ARF6 IL1F10 CXCL13 PLCG2 STAT1 BCL2L11 MERTK IL1RN IL37 ANAPC1 IL1R1 IL23A POLR2F POLR2H IL1A POLR2K POLR2L CHTM1 ZC3H8 ZNRD1 PSD4 ARL14 CKAP2L POLR1A POLR1C POLR1D POLR1F POLR1G MAPK1 FBLN7 TMEM87B SLC20A1 RGPD8 TULP1 IL6 TTL IL1RL2 NT5DC4 GATA3 CSF2 GRB2 CSF1 IL2 RAC1 IL1B PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260410%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway EZR SEPTIN2 MYL2 OCRL RDX RAB35 KIF23 HEL70 ARHA POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260410%WP5485%HOMO SAPIENS Post COVID neuroinflammation IL1A TLR4 CCL11 HMGB1 TMPRSS2 CXCL8 ACE2 IL2 TLR3 IFNA2 TNF IL4 IL18 MAPK1 IL1B IL6 IL12A IFNG IL10 TLR8 FURIN TLR7 GFAP COPPER HOMEOSTASIS%WIKIPATHWAYS_20260410%WP3286%HOMO SAPIENS Copper homeostasis COX11 ADAM10 PTEN STEAP3 FOXO1 SLC11A2 CCS HEL-S-44 SP1 FOXO3A APP JUN SLC31A1 MDM2 STEAP4 COX17 ATP7B ATP7A COMMD1 PIK3CA SLC31A2 ATOX1 SCO1 ADAM9 XAF1 MT2A STEAP1 STEAP2 GSK3B CCND1 PRNP CASP3 MT4 ADAM17 MT3 MT1A MTF1 MT1F MT1G BACE1 MT1B APC MT1E INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260410%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB IL1A IRAK1 AJUBA SQSTM1 HEL-S-71 PRKCZ TIFA NFKB1 TRAF6 UBE2V1 PURINE METABOLISM%WIKIPATHWAYS_20260410%WP4792%HOMO SAPIENS Purine metabolism HPRT1 ADSL DGUOK IMPDH1 AMPD1 HEL-S-70p XDH ADSS APRT ADA PNP POLYOL PATHWAY%WIKIPATHWAYS_20260410%WP690%HOMO SAPIENS Polyol pathway KHK SORD AKR1B1 ALDOB INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260410%WP453%HOMO SAPIENS Inflammatory response pathway LAMA5 IL5RA VTN TNFRSF1B IL5 CD40LG COL1A1 COL1A2 COL3A1 LAMB2 THBS1 LAMB1 TNFRSF1A LAMC2 LAMC1 CD40 CD80 IL2RG THBS3 IL2 IL4 IL2RA IL2RB IFNG ZAP70 LCK BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260410%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment MYC HEL2 BAD FOXO3A TIAM1 PLCG1 PARD3 DOCK7 PIK3CA NGFR PDPK1 TP73 RTN4R WASL YWHAZ PARD6B EEF2K ROCK2 YWHAQ IKBKB IKBKG MAP3K5 NRAS MAPK1 KIDINS220 HRAS MAPK3 MAP2K4 PARD6A JUN HEL-S-47e MAP2K1 MAP3K1 MAP2K2 GRB2 KRAS SOS1 RAF1 IRS1 PIK3CD PRKCI RAC1 LEF1 HEL-S-15 CREB1 RAPGEF1 MAP2K5 CRK BDNF ROCK1 PRKCZ EIF4EBP1 CDC42 EIF4E ARHA STAT3 CFL2 BCL2L11 PTPN11 MTOR RPS6KB1 BMP7 GSK3B TRADD HEL-S-1 CASP9 MAPK8 PAK1 CASP8 CHUK FRS2 FADD IQGAP3 NFKBIA EEF2 APAF1 TRAF6 MAPKAPK2 BCL2 LINGO1 CYCS MAPK7 LIMK1 YWHAG SORT1 NTRK2 BAX RPS6KB2 SH2B2 NPTX2 SMPD1 PRKCH MAPK11 PRKCB PRKCE PRKCA CTNNB1 TCF7L2 TCF7L1 ARHGAP35 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260410%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 TGFB1 CLDN4 ERBB4 MYC TNF CCND1 NRG3 ALPL ZEB2 ITGB1 ITGA6 SFRP1 TERT RETT SYNDROME%WIKIPATHWAYS_20260410%WP4312%HOMO SAPIENS Rett syndrome CRK SCN8A SCN2A FOXG1 HDAC5 NCOR2 SYNGAP1 NCOR1 SHANK3 BRAF SYNE2 HDAC1 SMC1A GABRA3 KDM5B TRRAP ACTL6B HTT GPS2 CHD4 HDAC8 MEF2C RHOBTB2 GNAO1 CECR2 CDKL5 SMARCA4 TAF1B TBL1X STXBP1 HIVEP2 EIF2B2 KCNJ10 SCN1A SMARCA1 XAB2 GRIN2B TBL1XR1 GABBR2 IMPDH2 SRRM3 TCF4 HAP1 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260410%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis FCRL3 PTPN22 PADI4 CD244 CD40 PHF19 MHC2TA BLK STAT4 ITGAV IL2RA IL6ST CTLA4 CCR6 HLA-DRB1 SLC22A4 TRAF1 MALE INFERTILITY%WIKIPATHWAYS_20260410%WP4673%HOMO SAPIENS Male infertility CCNK H4C9 PRDM9 SIRPG EPSTI1 SLC16A7 RAG1 NANOS1 FAT10 PRM2 PRM3 FOLH1 SPATA17 MSH4 TSSK4 DDX4 DAZ4 DAZ3 VCX DAZ2 STRA8 DND1 MOV10L1 H2BW1 TMEM132E XRCC3 PRMT6 TAS2R38 PUM2 DAZL PIWIL2 PIWIL1 PIWIL4 SPO11 HORMAD2 MSMB PACRG TEX15 CXXC1 ABLIM1 OR2W3 XPC PMS2 MAS1L P1 KDM3A USP26 CDC42BPA MLH3 HMGA1 REC8 CTCFL GNAO1 ERCC1 ERCC2 SEMG1 BRDT SRD5A2 NQO1 AHR PEX10 EP300 CDK9 CYP1A1 AHRR NOS2 THBS1 AGO2 MDM2 NFE2L2 CREBBP MTR SOX5 GPX1 POLG H3-4 RFC1 ETV5 CLU MMP2 MMP9 PON2 PON1 INSR UBE2B CYP17A1 HEL-S-61p HEL110 ABCB1 MTRR PEMT TNF TCN2 XRCC5 SHMT1 SIRPA PARP1 TNFSF6 BCL2 FAS APOB BRCA2 CYP26B1 HLA-DRA PSAT1 NR3A2 ATM TRIP13 SLC46A1 MTHFD1 CHD2 COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260410%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence TLR4 IL17A IL17RC IL17RA ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260410%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects ADAM10 PSEN2 CSNK1A1L APH1B VDAC3 PSENEN ATP2A1 DDIT3 ULK2 ULK1 PPIF PLCB4 PIK3CA SLC25A5 CACNA1F PLCB1 PLCB2 CACNA1S RTN4 KIF5A HEL-S-61 ATP2A2 TUBA1A PTGS2 IKBKB MAP3K5 NOS2 ERN1 APP IL6 RYR3 PPP3CA LRP5 LRP6 ATF4 CSF1 PSEN1 IL1B GPR83 BACE1 NAE1 MCU RB1CC1 WIPI1 CYBB TRAF2 ATG2A CHUK ADAM17 GRIN2B EIF2S1 APOE NOX4 CDK5R1 GRIN1 SHFM1 RELA MAPK9 BAD PPP3CC CHRNA7 PIK3R3 ITPR2 SLC25A4 PPP3R2 NRBF2 ATG2B IDE TUBA1C MME TUBB LPL TUBB2A KNS2 PSMA8 TUBA3E TUBB4B TUBB4A TUBB8 TUBB6 TUBB1 AMBRA1 ATG14 TUBA4A HSD17B10 RTN3 CACNA1C ARAF KLC4 NRAS KLC3 KLC2 TUBA2 TUBA8 MAPK1 SLC25A6 HRAS TUBAL3 BECN2 MAPK3 ADRM1 SLC25A31 MAP2K1 MAP2K2 BRAF MAPK10 CALM1 PLCB3 CDK5 KRAS RAF1 IRS1 PIK3CD HEL-S-162eP PSMD12 HEL-S-276 HEL-S-91n PIK3R4 PSMD13 PIK3R2 PIK3R1 PSMB6 AGER PSMD9 PSMD6 INS PSMD7 EIF2AK2 PSMB2 PSMD4 INSR PSMB3 PSMD2 PSMD3 PSMD1 MTOR PPP3R1 PSMC6 PSMA4 PSMC4 PSMA2 PSMC1 GSK3B TNF AKT3 CASP9 MAPK8 CALML6 CASP8 CALML3 CALML4 CASP3 FADD WNT3A AXIN1 DKK4 APAF1 APC IL1A WNT2B FZD10 FAS FRAT1 CYCS FRAT2 IRS4 TUBA1B APC2 WNT5B CSNK2A1 CSNK2A3 CSNK2A2 XBP1 CSNK1E AXIN2 WNT16 DKK1 DKK2 SFRP4 NFKB1 CSNK2B TNFRSF1A SNCA ATG101 DVL1 WIPI2 DVL2 CASP12 DVL3 WNT1 WNT3 FZD1 CTNNB1 WNT10B WNT10A FZD3 FZD2 FZD5 CSNK1A1 WNT4 WNT7B FZD7 FZD9 WNT7A FZD8 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260410%WP259%HOMO SAPIENS Nifedipine activity KDR MAPK1 PTK2B MAP2K1 PCNA BDKRB2 HEL-S-44 CYP3A4 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome H4C9 PLK1 GLUD1 MED15 SREBF2 VWF CLDN5 SNAP29 RTN4 RELN SHH RTN4R CLDN1 POLR2A SLC25A1 EGFR DGCR8 DROSHA PAK4 RORC RAN SLC2A4 TSKS EMC10 ZDHHC8 RCC1 PITX2 C22orf39 CLDN3 THAP7 SHOC2 TSSK2 HEL-S-80p ASF1A RTL10 NPRL2 TRMT2A ACTA2 ESS2 FGF8 HEL25 RAF1 KLHL22 GP5 UFD1L LRRC74B SEPT8 MRPL40 DGCR6L TNPO1 CRKL SCARF2 DGCR2 GP1BB C16orf35 GP1BA SEPT5 SLC7A4 CYP26C1 ALDH1A2 GNB1L DEPDC5 CCDC188 FOXC1 ARVCF TBX1 RANBP1 SERPIND1 P2RX6 ZNF74 PAX3 GP9 CDC42 RBX1 NKX2-5 NCOR1 HAND2 CLTCL1 FGF10 FGFR1 FOXA2 PRODH TXNRD2 GBX2 CDH15 HDAC3 PARK2 HIRA BCL2 HIRIP3 CYP26A1 CYP26B1 CDC45 DRD2 FOXC2 GSC2 FGFR2 HES1 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260410%WP2857%HOMO SAPIENS Mesodermal commitment pathway SMAD2 RPL38 SOX2 PRKAR1A TOX SETD2 TEAD2 TET1 VAV3 PPP2CA BMP4 TCF4 SNAI1 YAP1 BMPR2 LEFTY1 LEFTY2 FOXA1 SOX21 CEP250 HMGA2 PITX2 WDHD1 NFE2L2 DNMT3B TBX3 FOXH1 EMSY WDFY2 HPRT1 FGF8 GATA6 MBTD1 EPB41L5 UBR5 FZD4 ATP8B2 GDF3 ZFHX4 TRERF1 NABP2 LEF1 PLCH1 RARB NODAL FOXC1 PIAS1 TRIM71 TBX1 PHF6 HES7 NR2A1 ZIC3 CCDC6 ACVR1 TRIM5 ADAM19 SMAD6 C1QBP TBX6 TWSG1 JARID2 INHBA SCHIP1 CSRP2 SLC2A12 MSGN1 PAX6 PARP8 ARL4A NR1B3 HAND1 TOX3 WDCP AEBP2 ACVR2B ARID5B ACVR2A MEIS1 AHDC1 BCORL1 ZNF462 SMAD1 ELP4 FGFR1 ZIC5 ACACA RGS10 SESN1 MIXL1 BMP7 FOXA2 CUL4B CCND1 CRTC1 LATS1 SMAD4 WNT3A EXT1 AXIN1 EXT2 POU5F1 C9orf72 BHLHB2 SOX17 PBX3 TRIM28 ZIC2 AXIN2 DKK1 GATA3 CTBP2 NLK KLF4 NOG KLF5 PBX1 FOXC2 WNT3 HTT TCF7L1 AMH FZD5 FZD8 BMPR1A CILIOPATHIES%WIKIPATHWAYS_20260410%WP4803%HOMO SAPIENS Ciliopathies TMEM67 RAB23 PDE6D NPHP3 EVC2 BBS2 NEK8 BBS1 USP9X PCARE SCLT1 DCDC2 BBIP1 INPP5E TTC8 MKS1 IFT27 CEP41 TRIM32 CLUAP1 OCRL INTU HEL-S-296 SMO SUFU KIF7 GLI3 ADCY6 CCDC40 ANKS3 XPNPEP3 PIBF1 NPHP1 PIK3R4 ODAD1 ODAD3 ODAD4 CCDC28B MCIDAS TBC1D32 NEK2 DNAAF3 DNAAF2 DNAJB13 DNAAF6 FAM161A TMEM138 CCNQ CCNO AK7 CEP78 NEK9 DNAAF19 ARL2BP TMEM237 UNC119 DNAL1 ZNF423 DNAAF11 AHI-1 HYDIN CCDC39 DNAI2 CFAP52 PLK4 TOPORS RP1 NME7 NME9 WDR51B ZMYND10 KIZ CFAP53 KATNIP DRC1 DNAH6 RSPH9 CFAP298 POC1A RAB28 DNAI1 TUB DYX1C1 C2CD3 RSPH3 CEP19 RPGRIP1 RP1L1 CENPF TTLL5 TCTN3 RSPH1 TCTN2 ALMS1 TCTN1 SPAG1 HYLS1 B9D2 ATXN10 CC2D2A OFD1 DYNC2I2 INVS TRAF3IP1 IFT172 RPGRIP1L CEP164 CCDC41 PKD1 IFT52 FLCN ZIC2 TMEM107 TULP1 CNGA1 NEK1 BBS9 BBS7 IFT57 KIAA0753 BBS5 CEP290 CPLANE1 BBS4 DYNC2H1 IQCB1 CFAP418 TMEM231 IFT140 IFT80 TMEM17 CFAP410 WDR35 LZTFL1 B9D1 EVC BBS10 IFT43 BBS12 RP2 IFT81 GPR161 MAK TMEM216 EFHC1 WDPCP CNGB1 SDCCAG8 CEP104 ARL6 ARL3 DYNLT2B CRX PKD1L1 DYNC2LI1 PKHD1 ARL13B MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260410%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances GOT2 SLC25A22 SLC25A13 SLC25A12 GLUD1 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260410%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways CBS GAD1 CTH HEL-S-44 GAD2 pcap HEL-S-61p MTHFD2 HEL-S-182mP CDO1 PCYT1B CHKB PCYT2 CHKA ETNK1 PEMT AHCYL2 MAT1A BAAT CHPT1 PSPH GCLM SHMT1 AGXT2 DHFR AHCYL1 DNMT3L PHGDH SLC25A48 GPX7 GCLC BCAT1 HEL-S-51e BCAT2 BHMT2 HEL-S-75p MTHFD1L TYMS AMT PSAT1 CHDH DNMT3B ALDH7A1 MTR GPX2 GPX1 GPX4 HEL-S-64p GPX3 GPX6 HEL-75 CEPT1 MTHFD1 MTHFD2L MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response BBC3 CDK6 CHEK2 MYC TLK1 CDC2 CDK4 TNFRSF10B TP53AIP1 SESN1 CCND3 RB1 PRKDC CCNB2 CCND1 PML CASP9 RAD51 CASP8 CASP3 CDKN1A APAF1 RRM2B GADD45B GADD45A GADD45G FAS CCNG1 CYCS CCND2 SFN CHEK1 H2AX RAD1 ATRIP HUS1B ATR TLK2 RAD9A CCNB3 CCNE1 BAX FANCD2 CDK2 MDM2 RAD50 CCNE2 CDK5 MRE11A ATM BRCA1 NBN PMAIP1 SMC1A CDKN1B RAD52 RAD17 PIDD1 RFC1 CCNB1 DDB2 CREB1 PI3K AKT SIGNALING%WIKIPATHWAYS_20260410%WP4172%HOMO SAPIENS PI3K Akt signaling CDK6 PTEN LAMB4 EPOR KDR FLT3LG EPHA2 PDGFD PIK3CA PDGFC NGFR TCL1B PPP2R1B IGF2 IGF1 PHLPP2 CSHL1 GHB3 PPP2R5E FGF8A PPP2R5B PPP2R5A PPP2R3C CDKN1A PPP2R3A PPP2R2C PPP2R2B PPP2R2D PPP2CA FGF7B FGF7A GYS1 KIT FGF18 FGFR3 ATF2 FGF6B NTF4 NTF3 IKBKB IKBKG TSC1 VEGFB FGF5C IL6 VEGFC RHEB VEGFD CCNE1 THBS1 CDK2 MDM2 FGF2 CSF3 ATF4 FGF7 CSF1 FGF8 EPO ITGB3 ITGA2B PDGFRA TSC2 PCK1 COL4A2 MYB COL4A1 PPP2R2A COL4A4 COL4A3 COL4A6 COL4A5 PPP2R3B CSF1R EFNA5 EFNA4 FGF20 FGF23 FGF22 MCL1 BDNF XB EFNA1 EFNA3 FGF14 IL3 KITLG EFNA2 FGFR4 FGF13 FGF12 PHLPP1 FGF10 FGFR1 ITGB1 FLT1 ITGB4 FLT3 STK11 FLT4 LAMC2 DDIT4 LAMC1 TCL1A ITGAV ITGA4 ITGA2 SYK ITGA1 NGF CHUK IFNB1 ITGA6 CD19 TLR4 LAMA5 PRKAA2 COL2A1 LAMA1 PIK3AP1 LAMA4 LAMA3 PRLR NTRK1 NTRK2 ANGPT4 THBS2 ANGPT2 COL1A1 LAMB3 ANGPT1 EGF LAMB2 LAMB1 RPS6KB2 BRCA1 CDKN1B SPP1 JAK3 PRKCA OSMR PKN2 RELA TNC OSM VEGFA PCK2 COMP G6PC2 TNR G6PC3 MYC CHRM2 BAD VTN CHAD CDK4 PRKAA1 FOXO3A COL1A2 ITGB5 PIK3R3 ITGB8 ATF6B PIK3R5 ITGB7 ITGB6 GNG10 VWF G6PC1 ITGA7 IGF1R CCND3 THBS4 GNG12 PDPK1 THBS3 GNG11 RELN PPP2R5C GNG13 RBL2 GNB2 GNB4 GNB3 GNB5 GNG2 GNGT1 GNGT2 GNB1 EGFR FGF21 EIF4E1B GNG3 GNG5 CDC37 GNG4 NRAS GNG7 MAPK1 GNG8 HRAS MAPK3 MAP2K1 GYS2 MAP2K2 HEL-S-125m KPG_010 IBSP GRB2 GHR KRAS SOS1 RAF1 SOS2 CREB3L3 CREB3L4 IRS1 CREB3L2 IF1AA9 PIK3CD RPTOR GH1 MLST8 RAC1 JAK1 IFNAR2 CREB3 RPS6 CREB5 CREB1 CHRM1 CSF3R IFNAR1 PIK3R2 PIK3R1 IFNA13 IFNA14 IFNA16 IFNA17 INS F2R EIF4EBP1 INSR IFNA10 EIF4E EIF4B BCL2L11 MTOR IFNA21 RPS6KB1 HSP90AB1 IFNA1 IL3RA IL2RG GSK3B PDGFA CCND1 AKT3 CASP9 IL2RA IL2RB PPP2R1A HGF TGFA PPP2R5D LPAR1 LPAR2 LPAR3 LPAR4 TNFSF6 MET BCL2 IFNA4 IFNA7 IFNA6 IFNA2 CCND2 IFNA8 COL9A1 COL9A3 COL9A2 PKN3 GHB2 PKN1 CSH2 BCL2L1 COL6A1 SGK1 COL6A6 SGK2 NFKB1 COL6A5 IL6R CCNE2 IL2 IL4 IL7 IL7R FGF9 PRL FGFR2 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260410%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis IRF9 IFNAR1 MX1 SOCS1 OAS1 STAT1 STAT2 IFNGR1 IFIT1 IFNGR2 IRF1 JAK1 IFNAR2 IFNG TYK2 IFITM1 PSMB8 PIAS1 TAP1 IFI35 IFIT3 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome CLASP2 BRD4 ATP5PB TMEM270 MYC ATP5F1D USF1 ATP5F1E TBL2 ATP5PO GTF2IRD1 PCNA UBIAD1 ULK1 ACACB ACACA PRKG1 CLDN5 CLDN4 OGDH HDAC2 DLD RB1 SNAP25 HOXC8 CDKN1C HMGA1 GRIP1 GTF2I CLTC CLDN1 LAT2 VAMP2 BTK ATPAF2 HDAC3 SQSTM1 HSPA2 FAS LIMK1 H2AX MAPK3 CLDN3 EIF2A UBE2L6 CHTF18 ATP5G1 ATF4 HEL-S-271 GRB2 BCL7B BUD23 VPS9D1 UBE2E3 VPS37C UBE2E1 BAZ1B VPS37D NRG1 VPS37A VPS37B MLXIPL CLIP2 DDX21 METTL27 FKBP6 CTNNB1 VPS28 STX1A ATPAF1 SF3B1 TRIM50 NUP62 TSG101 ATP8 PKLR RFC2 ATP6 SMARCA5 ATP5MC2 DEK ATP5MC3 FBLN2 HEL-S-123m HEL-S-15 MYO1C ABHD11 HEL-S-162eP FBLN5 CLASP1 FZD9 MYBBP1A HDAC6 MVB12A FBN1 EIF4H FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2879%HOMO SAPIENS Farnesoid X receptor pathway ABCB4 PPARGC1A BAAT IP6K3 ABCB11 FKBP5 CYP8B1 SLC27A5 FGF8A UGT2B4 RXRA NR1H4 SULT2A1 CYP7A1 NR0B2 SLCO2B1 CYP3A4 NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260410%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma STAT3 IL6ST JAK1 IL6 RELA IL11 IL11RA JAK3 SOX4 NFKB1 IL6R NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260410%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium ERBB4 BDNF MYC TCF3 DAB1 NTRK3 ID1 PAX6 CDK5R1 PLXND1 SOX2 CXCL12 LRP8 ID2 NDEL1 MAP1B NTRK1 NEUROG3 MAP2 NTRK2 AGRN FAIM STAT3 PAFAH1B1 DISC1 APP NEUROD1 IL17A CDK5 NGFR MRE11A NUMB RTN4 RELN GSK3B NRG1 KDM1A RTN4R VLDLR PSEN1 NGF MEF2C NOTCH1 ASCL1 GHRL RET HES1 TCF4 GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260410%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PLA2G2A HMFN0839 PTPMT1 PGS1 PIP5K1A GPAT4 GPAT2 CDS2 IPMK MOGAT3 CDIPT PIK3CA PTDSS1 CHKB PCYT2 PI4K2A PEMT CHPT1 PIK3CD GPAM GNPAT GPD1 AGPS CEPT1 LPIN1 LPIN2 PEPTIDE GPCRS%WIKIPATHWAYS_20260410%WP24%HOMO SAPIENS Peptide GPCRs OPRK1 ATP8A1 BRS3 MC4R CCKAR GHSR LHCGR NPY5R IL8RB AVPR1B NPY1R TACR2 OPRM1 AVPR1A SSTR3 CCR10 SSTR4 FPRL2 CCR1 TRHR SSTR5 CCR5 OPRD1 NPY4R FPR1 MC2R OXTR GALR3 NPY2R GALR2 GALR1 TAC4 NTSR2 NMBR CXCR1 MC1R TACR1 MC5R SSTR2 EDNRA FSHR TSHR EDNRB HCRTR2 CCR8 HCRTR1 CCR7 MC3R CCR6 CCR4 CCR3 CCR2 CX3CR1 AGTR2 CXCR5 CCKBR CXCR6 CXCR3 GRPR GNRHR AGTR1 FPR2 BDKRB2 BDKRB1 AVPR2 CXCR4 FY C5AR1 NTSR1 C3AR1 TACR3 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260410%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc OGDH SUCLG2 DLD HEL-S-32 PCK1 HEL-S-26 HEL60 DLAT FH PDHA1 SDHA ACLY CS PC RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260410%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation LTB4R MTOR CMKLR1 GRK1 PIK3CD FPR2 PIK3CA EPHB2 FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260410%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses HEL-S-53e CYP2E1 ADH5 CBS MTR CEBPB CREB1 SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260410%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD HMGB1 CHUK RELA AGER NFKBIA IKBKB IKBKG NFKB1 THBD CCL18 SIGNALING%WIKIPATHWAYS_20260410%WP5097%HOMO SAPIENS CCL18 signaling MMP2 ZEB2 AK4 CCR8 CDH2 PTK2B SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260410%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 IL5 SIGNALING%WIKIPATHWAYS_20260410%WP127%HOMO SAPIENS IL5 signaling IL5RA PIK3R2 PIK3R1 STAT1 MAPK1 STAT3 FOXO3A PTPN11 MAPK3 RPS6KB1 JUN MAP2K1 RPS6KB2 MAP2K2 CSF2RB LYN GRB2 RPS6KA1 KRAS SOS1 RAF1 GSK3B IL2 SYK JAK1 SPRED1 RPS6 BTK STAT5B GSK3A CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260410%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism POR CYP11A1 HSD3B2 HSD3B1 HSD17B3 STAR H6PD HSD11B1 HSD11B2 SRD5A2 CYP17A1 CYP11B2 CYP21A2 NAD METABOLISM%WIKIPATHWAYS_20260410%WP3644%HOMO SAPIENS NAD metabolism SIRT4 SIRT5 SIRT7 NT5E SIRT2 SIRT3 NMNAT1 NAMPT SIRT1 SIRT6 NRK NMNAT3 NMNAT2 NADK PARP1 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260410%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells TGFB1 TLR4 CD40 SELE CCL5 CCL2 CD40LG VCAM1 IL1B SELP SELPLG TLR7 PF4 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260410%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease KCNN3 RBPJ C4orf54 BEND6 NOX3 EFL1 SHCBP1 ARHGAP31 IBTK EIF6 SBDS CDC42 SP1 MAPK1 MAPK3 NFKB1 DGUOK NCF2 NCF4 CYBB CYBA RAC1 NOTCH1 GTF2I BTK TLR9 DOCK6 TLR8 CYBC1 NCF1 COX4I2 DLL4 CXXC5 CHCHD2 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260410%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 IFNAR1 PTEN PIK3R1 PPP3CC STAT4 FYN FOXO3A CTLA4 MTOR PLCG1 PTPRC IL18R1 NFATC1 PDPK1 GSK3B TNF CCND1 CHUK PRKCQ IL12B IFNB1 LAT CDKN1A IL12A IL23A NFKBIA CARD11 BCL10 MYD88 IRF2BPL IKBKB LTA IKBKG IL23R TSC1 MAPK1 FOS CD3G HRAS CCL19 CDKN2A CD3E MAPK3 CD3D RHEB BAX JUN HLA-DRA MAP2K1 HLA-DRB1 BCL2L1 MAP2K2 CCL28 NFKB1 IL17A GRB2 CD80 SOS1 DEPTOR RAF1 IL2 IL4 TSC2 PIK3CD GRAP2 RPTOR MLST8 LCP2 ICOS IFNAR2 RELA IFNG TYK2 RICTOR ZAP70 IL12RB1 LCK FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260410%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 LPL APOA2 APOA4 APOA5 APOC2 LDLR LIPC SEL1L GPIHBP1 PLTP LMF1 MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260410%WP2006%HOMO SAPIENS miR targeted genes in squamous cell RARS1 ADAR NCL PTMAP7 SRSF9 RAI14 SDCBP PNP GAS2L1 MAP3K8 SLC4A10 GOLGA7 ATP6V0E1 P4HA2 TNFRSF10B CHMP2A SRPRB DKFZp761E1322 PISD PICALM RAB34 SYNE2 POM121 TMED10 ADIPOR2 RTN4 SIGMAR1 MRPL20 SEC23A ATP6V1F HSD17B12 HMGA1 TBCA SH3BP4 PDLIM7 ARF4 SLC12A2 FBXW11 GALNT7 ATP2A2 MRC2 BET1 GYS1 TUBA1A SPTLC1 YWHAQ TMEM43 GALNT1 NRP1 SH3BGRL3 HMOX1 HOXA7 ANXA2 PRPF40A CTDSP1 HEL-S-26 RHEB THBS1 DNAJB1 FGF2 POLR2C TPM3 TPM1 AP3D1 ARCN1 FMNL2 POLD2 VCAM1 AP2A1 PXDN NF2 GFPT1 NEDD4 SMAD1 CUL4B CPNE8 LAMC1 VEZT PWP1 DHX57 E2F3 CIAO2A HEL-S-30 SLC38A1 CBFB TRAM1 FNDC3B FNDC3A UBE2J1 TGFBR2 COMMD9 ATP6V1C1 MET PEDS1-UBE2V1 MOV10 ANP32B RNP24 MAGT1 TMED7 CSDE1 MRPS33 AKAP8 PPP1R7 MPZL1 ELOVL5 TMEM59 SPCS3 AXL LAMTOR5 POGLUT3 HES1 TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD ERBB SIGNALING%WIKIPATHWAYS_20260410%WP673%HOMO SAPIENS ErbB signaling CRK CAMK2G MYC PIK3R2 NCK2 PIK3R1 NCK1 CBL BAD EIF4EBP1 PLCG2 BCL2L11 MTOR RPS6KB1 SHC4 BTC SHC2 SHC3 PIK3R3 PIK3CA PDPK1 GSK3B CCND1 AKT3 MAPK8 PAK1 AREG CDKN1A TGFA ERBB2 ERBB4 EGFR HBEGF ERBB3 FOXO1 PAK6 ARAF NRAS NRG2 EREG MAPK1 PAK4 NRG4 HRAS ABL2 MAPK3 EGF MAP2K4 JUN MAP2K1 RPS6KB2 MDM2 MAP2K2 BRAF MAPK10 GRB2 KRAS SOS1 RAF1 SOS2 CDKN1B NRG1 PIK3CD NRG3 CRKL PRKCB PRKCA SRC MAPK9 CAMK2D CAMK2A STAT5B 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5402%HOMO SAPIENS 10q22q23 copy number variation ADAM10 GLUD1 CEBPA DNAJB13 MAD2L2 PPARG OPN4 MAT1A RSPH9 RSPH3 BMP2 ERBB4 RSPH1 MGRA SH2D4B FAM25A BUB1B ADIRF LDB3 GHITM IQUB WAPAL ROPN1L RSPH6A ACTN2 NFKB1 NME5 CDHR1 MMRN2 SIRT4 DYDC2 DYDC1 RAD21 ZMYND11 RGR TNFSF11 PDS5B PDS5A SMC3 GPR15LG SMC1A SNCG SH3GL3 GPR15 SUSD2 STAG1 TSPAN14 NRG3 LRIT2 SHLD3 LRIT1 PRXL2A SHLD2 SHLD1 RSPH14 CCSER2 VEGFA BMPR1A PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260410%WP4971%HOMO SAPIENS Phosphoinositides metabolism MTMR1 MTMR2 PIK3R4 PTEN MTMR8 PIK3C2G PIK3C2A SBF2 STM7 MTMR6 PIK3C2B MTM1 PIP4P2 PIP4P1 INPP5D PLCH2 PLCG2 PIP4K2A PIP5K1A PLCE1 PIP4K2B PLCG1 PIP5K1C SACM1L OCRL PIKFYVE PLCB4 PIK3CA PLCB3 PLCD3 PLCB1 PLCB2 PLCD4 PIK3CD MTMR10 MTMR3 MTMR12 MTMR11 PLCH1 MTMR9 MTMR4 SBF1 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260410%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling RAF1 FOXO1 EIF4EBP1 TSC2 PRKCA MAPK1 CGA APPL1 H3-4 SRC MTOR FSHR RPS6KB1 MAPK3 RPS6 RHEB RPS6KB2 FSHB SGK1 CREB1 MAPK14 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling EGLN2 MMP2 IL1A MMP9 SELE CXCL8 PTGS2 IKBKB CD40LG NFKB2 IL6 REL NFKB1 TNFRSF1A BIRC5 CSF2 BIRC2 BIRC3 BCL2A1 IL2 TNF BCL2L2 CCND1 MMP3 VCAM1 CHUK IL1B RELA RELB CXCL2 VEGFA TRAF6 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome SLC35G5 PRSS55 CSTA PRSS51 MTMR8 MCRS1 DEFB136 CGAS C8orf74 DEFB135 BLK MTMR6 DEFB134 TBX5 MFHAS1 FAM167A FCGR2B XKR6 SLBP TERT S100A10 HEL-S-130P AXIN1 HSPD1 TLR4 RP1L1 SGPL1 MAPK1 BMP1 PDX1 MSRA NKX6-1 SLC2A4 MAPK3 SOX7 TNKS RAF1 GATA4 TERF1 CTNNB1 PPP1R3B FCGR2A MTMR9 NEIL2 ERI1 NUMA1 FDFT1 PINX1 HEPACAM2 CLDN23 LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2874%HOMO SAPIENS Liver X receptor pathway NR1H3 RXRA SCD CYP7A1 CYP2B6 FASN ABCG8 ABCG5 CYP3A4 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260410%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway CDK6 HEL-S-34 PIK3R2 PIK3R1 SMAD2 BAD CDC42 dik STAT1 CDK4 STAT3 MTOR RPS6KB1 PIK3R3 PIK3CA TGFB1 RB1 E2F2 E2F3 CCND1 CASP9 AKT3 RAD51 MAPK8 PAK1 CHUK SMAD4 CDKN1A TGFA TGFBR1 TGFBR2 ERBB2 EGFR GADD45B GADD45A GADD45G BRCA2 IKBKB RAC3 PAK6 ARAF IKBKG BAK1 MAPK1 PAK4 CDKN2A MAPK3 EGF BAX MAP2K1 RPS6KB2 BCL2L1 MAP2K2 BRAF NFKB1 RALBP1 MAPK10 KRAS PLD2 RAF1 PIK3CD POLK RAC1 JAK1 RELA DDB2 MAPK9 RALA RALB VEGFA THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260410%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production PRKAA2 SLC5A5 RAF1 RAP1A TRH PRKCA DUOX1 PRKAA1 CLCN5 MAPK1 CGA TG TSHR HEL-S-5 DUOX2 MAPK3 MAP2K1 MAP2K2 NFKB1 CREB1 TPO FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260410%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 LPL APOA2 ANGPTL4 APOA5 LDLR SEL1L GPIHBP1 LMF1 APOA4 APOC2 LIPC ANGPTL8 ANGPTL3 PLTP EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260410%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer RBPJ CLDN7 SMAD2 EZH2 SPARC VTN ID2 PIK3R3 CLDN5 PIK3CA CLDN1 MAPK13 SNAI1 TJP1 CTDSP1 MEF2D MAPK1 SUZ12 HRAS MAP2K6 MAPK3 MAP2K3 MAP2K4 MAP2K1 GDF15 MAP2K2 CLDN3 MAPK14 LRP5 MAPK12 LRP6 GRB2 KRAS SOS1 RAF1 CDH2 JAG2 FMNL2 SOS2 JUP COL4A2 FZD4 PALS1 COL4A1 PIK3CD COL4A4 COL4A3 COL4A6 COL4A5 WNT9B WNT9A NOTCH1 WNT8A WNT8B NR2C2 CLDN23 MMP2 MMP9 FOXQ1 PIK3R2 PIK3R1 TWIST2 NOTCH2 NOTCH3 TUSC3 HEL-S-79 CLDN2 CDKL2 CLDN6 CLDN9 PKP2 PKP1 EIF5A2 NRP2 CLDN22 CLDN4 TGFB1 CLDN20 CLDN24 CLDN11 FOXM1 CLDN10 CLDN15 CLDN14 CLDN19 STRAP GSK3B CLDN18 CLDN17 CLDN16 TMPRSS4 AKT3 CRB3 EED MAPK8 PAK1 SMAD4 LATS2 WNT3A PROX1 TGFBR1 TGFBR2 TRAF6 WNT2B FZD10 ID1 RBBP4 WNT5B TWIST1 PKD1 SNAI2 WNT16 MMP15 NUBPL WNT1 FOXC2 MAPK11 WNT3 FZD1 CTNNB1 WNT10B ZEB2 WNT10A FZD3 HIF1A FZD2 FZD5 WNT4 WNT7B FZD7 FZD9 DLL3 DLL4 WNT7A FZD8 FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260410%WP206%HOMO SAPIENS Fatty acid omega oxidation HEL-S-53e CYP2E1 ADH1C HEL-S-117 ADH7 CYP1A1 ADH6 ALDH2 CYP4A11 HEL-S-4 CYP2A6 ADH1A CYP3A4 BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260410%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine SPR JDP1 PAH PTS PNMT AANAT DHFR ASMT DBH TH MAOA LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260410%WP3935%HOMO SAPIENS Leptin insulin signaling overlap LEP PDPK1 SOCS3 IRS4 INS SOCS1 IRS1 INSR STAT3 DGKZ SOCS2 PIK3R3 LEPR MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260410%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis IL1A TLR4 MYD88 CXCL8 IKBKB CCL4 IKBKG CCL3 IRF1 NFKB2 IL6 REL NFKB1 MAPK14 ELANE TNF MAPK8 LCN2 IRAK1 VCAM1 CHUK RELA MAP3K7 IRAK4 RELB IL10 NFKBIA MAP3K7IP1 TLR8 TRAF3 TLR7 TRAF6 IRF7 GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260410%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells GCG IL6 GLP1R INS SLC2A2 IL6R NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260410%WP4331%HOMO SAPIENS Neovascularization processes ACVRL1 MMP9 KIT SMAD2 CXCL12 KITLG NOTCH3 EPHB4 KDR MAPK1 MAPK3 ANGPT1 NFKB2 REL SMAD1 SMAD9 NFKB1 FLT4 TGFB1 DKFZp781O1323 MAPK8 EPHB2 HIF1A NOTCH1 RELA MAPK9 CXCR4 RELB TGFBR1 DLL4 INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260410%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide TLR4 MYD88 IFNB1 IFNG TNF TLR9 MAP1LC3A IRF3 NFKB1 TRAF6 DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260410%WP710%HOMO SAPIENS DNA damage response only ATM dependent BBC3 PIK3R4 PTEN MYC PIK3R2 PIK3C2G PIK3R1 PIK3C2A PIK3C2B BAD CDC42 INSR ARHA FOXO3A BCL2L11 NFKB2 PIK3R3 PIK3R5 PIK3CA TGFB1 G6PC1 HMGB1 CCND3 PPP2R5C TP73 GSK3B RBL2 CCND1 AKT3 MAPK8 PPP2R5E SMAD4 BCL6 CDKN1A MLKL WNT3A MAP3K7 CCNG2 AXIN1 APC ERBB2 TNFSF6 WNT2B BCL2 FRAT1 CCND2 LDLR RAC3 BAK1 NRAS BIK WNT5B MAPK1 HRAS CDKN2A WNT16 BAX JUN MAP3K1 MDM2 NFKB1 MAPK10 GRB2 KRAS ATM SOS1 PMAIP1 SOS2 CDKN1B DVL1 DVL2 IRS1 DVL3 PIK3CD WNT1 WNT3 CTNNB1 WNT10B TCF7L2 RAC1 WNT10A TCF7L1 LEF1 MAPK9 WNT4 WNT7B WNT7A PCK2 FOSL1 HEART DEVELOPMENT%WIKIPATHWAYS_20260410%WP1591%HOMO SAPIENS Heart development NFATC3 BMP2 NFATC2 BHLHB2 ERBB3 TBX5 BMPR2 HAND1 MAPK1 NKX2-5 PTPN11 HAND2 VEGFB SMAD1 VEGFC FGF10 PITX2 FOXH1 FOXA2 NFATC1 GATA6 FGF8 GATA4 SHH FOXC2 HEY2 CTNNB1 MEF2C SMAD4 NOTCH1 BMP10 TBX20 FOXC1 SMYD1 IRX4 TBX1 ISL1 TBX2 VEGFA NFATC4 BMP4 BMPR1A SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260410%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IRF9 IFNAR1 IFNA4 IFNA13 ACE2 IFNA7 IFNA14 IFNA6 IFNA16 IFNA2 IFIH1 IFNA17 MAVS IFNA8 RIGI IFNA10 STAT1 STAT2 IFNA21 IFNA1 TLR3 IF1AA9 TBK1 IKBKE JAK1 IFNAR2 IFNB1 TYK2 TICAM1 IRF3 TRAF3 OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260410%WP12%HOMO SAPIENS Osteoclast signaling CTSK IFNAR1 TRPV5 TNFSF11 TNFRSF11B ITGB3 ATP6V1G1 SPP1 AIMP2 MAPK8 IFNB1 TNFRSF11A GPR68 ACP5 NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway SNW1 MITA IFIH1 MAVS CXCL12 RIGI IFNK TRIM25 IFNA1 TNF TRADD MAPK8 NFKBIB CASP8 TBK1 TRAF2 CASP10 IKBKE CHUK IFNB1 FADD MAP3K7 NFKBIA DHX58 IRF3 TRAF3 ATG5 TRAF6 MAPK13 IRF7 TANK DDX3Y OTUD5 DDX3X ISG15 AZI2 SIKE1 RNF125 CXCL8 IFNE CYLD PIN1 TBKBP1 IKBKB ATG12 IKBKG MAP3K1 NFKB1 MAPK14 MAPK12 MAPK10 RIPK1 NLRX1 MAPK11 RELA IFNG MAPK9 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260410%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes ACSL3 ABCA1 ELOVL4 MYLIP ELOVL3 PLPP6 ACSL1 HMGCS1 NR1H3 CYP46A1 HMGCR TM7SF2 HSD17B7 CYP7A1 SCD NR1H2 CH25H GGPS1 IDI2 ACAT2 ABCG1 FADS2 ELOVL5 ELOVL2 IDI1 CYP27A1 FDPS MVK CYP51A1 DHCR24 MSMO1 EBP PMVK SC5D MVD LBR FDFT1 LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260410%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance ABCB1 HIF1A CDKN1A BCL2L1 PURINERGIC SIGNALING%WIKIPATHWAYS_20260410%WP4900%HOMO SAPIENS Purinergic signaling LPAR4 P2RY8 P2RY6 GNAT2 P2RY4 GNAT3 PANX1 P2RY2 P2RY1 GNAT1 P2RY10 P2RY14 GNAZ P2RX7 P2RX5 P2RX4 ADORA2B P2RX3 ADORA2A P2RX2 P2RX1 GNAI3 GNAI1 GNAO1 GNAS P2RY13 GNA11 P2RY11 P2RX6 ESTROGEN SIGNALING%WIKIPATHWAYS_20260410%WP712%HOMO SAPIENS Estrogen signaling BCL2 IKBKB IKBKG SP1 MAPK1 FOS CHUK GNGT1 GNB1 MAPK9 GNAS JUN MAP2K1 BRAF NFKB1 CREB1 GPER MAPK14 PIK3CA PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260410%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response HEL-S-125m DNAJC3 DNAJB11 ATF3 BBC3 DNAJB9 ATF4 ERP27 PPP1R15A UBE2E1 HEL-S-89n TRIB3 XBP1 BCL2L11 HEL-S-99n ERN1 SULT1E1 DDIT3 NFE2L2 NARS1 EDEM1 ASNS EIF2A GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP4159%HOMO SAPIENS GABA receptor signaling ABAT AP2A1 GAD1 AP2S1 GAD2 GABRB3 GABRB2 GABRB1 SLC6A1 AP2A2 GABRE GABBR1 GABRQ SLC32A1 GABRA2 SLC6A11 GABRP ALDH9A1 GABRA6 GABRA5 GABRA4 GABRA3 GABRG3 GABRG2 GABRG1 AP2M1 GPHN GABBR2 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2406%HOMO SAPIENS Cardiac progenitor differentiation INHBA PAX6 INS TBX5 LIN28B SOX2 KDR NKX2-5 MIXL1 TGFB1 FOXA2 IGF2 GSK3B IGF1 SIRPA WNT3A TBX20 POU5F1 IRX4 ISL1 BMP4 KIT NCAM1 SOX17 ZFP42 BMP1 TNNI3 DKK1 FGF2 MAPK14 ROR2 NOG MYL2 MESP1 GATA4 SOX1 PDGFRA NRG1 THY1 MYH6 TBXT LIN28A MEF2C NOTCH1 SCN5A CXCR4 NODAL MYLK3 MESP2 4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260410%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression PIK3R2 PIK3R1 RAF1 EIF4EBP1 TSC2 PIK3CD EIF4E HEL164 MAP3K5 PRKAA1 TSC1 MAPK1 MTOR MAP2K6 MAP3K11 MAPK3 MAP2K3 MAP2K1 PIK3R3 MAP2K2 PIK3CA ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260410%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology TMEM43 SMAD2 ADCY1 ADCY8 ADCY6 BANF1 NRAS ARHA MAPK1 HRAS ADCY9 MAPK3 EMD MAP2K1 MAP2K2 SYNE2 CTGF SYNE1 TGFB1 WWTR1 GRB2 KRAS SOS1 SOS2 ADCY3 LEMD3 SYNE4 SYNE3 SUN1 HEL-S-7a HEL-S-61 YY1AP1 PLEC SMAD4 HEL-S-15 LBR METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260410%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases LPL APOA2 SCARB1 PCSK9 APOE APOB LDLR ABCA1 ANXA2 MTTP APOC2 LIPG LIPC FRAGILE X SYNDROME%WIKIPATHWAYS_20260410%WP4549%HOMO SAPIENS Fragile X syndrome SHANK1 EPS8L1 PTEN ABAT MAP1B PRKAR1A PLCG1 CYFIP1 FMR1 PLCB1 RAP1GAP PPP2R5B CAMK1 ARAF SYNGAP1 NF1 HOMER1 TSC1 MAPK1 DICER1 DLG4 CDKN2A TARBP2 APP RHEB PPP3CA MAP2K1 AGO2 MAP2K2 BRAF GRB2 KRAS SOS1 DEPTOR RAF1 SH3GL3 EIF4A1 TSC2 CAMK4 DAG1 RPTOR AP2M1 MLST8 CPT1A CREB1 EPHA4 EEF1A1 MMP9 BDNF AP2A1 GAD1 FYN EIF4E AP2S1 PTPN11 MTOR CLTCL1 RPS6KB1 EIF4G1 PTPN5 GABRB2 ABCD3 GABRG2 ARC GRIA2 GRIP1 KCND2 TTI1 CLTC AKT1S1 CLTB CLTA GRIN2B CNR1 DKFZp762B153 NTRK2 GRIN1 AKAP5 SLC6A1 PRKCA ALDH3A2 SRC CYFIP2 SH3GL1 GRIP2 AGAP2 GPHN EIF4EBP2 ARHGAP32 KCNC1 DLGAP3 CAMK2A DUSP3 ALDH5A1 TBC1D7 HCN1 PICK1 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260410%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway 5HT1A MAPKAPK3 MAPKAPK2 RAP1A HTR1E HTR1F HTR1D HTR1B ARHA MAPK1 STAT3 FOS MAP2K6 MAPK3 MAP2K3 RASGRF1 MAP2K1 MAP3K1 MAP2K2 BRAF MAPK14 PIK3CA PDPK1 GNAI3 GNAI1 HTR2A RPS6KA5 GNAO1 CREB1 INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260410%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PIK3R2 ROCK1 PIK3R1 MOB1A YAP1 TRIO ARHA MAPK1 TSC1 MTOR PKN3 PKN1 PIK3R3 PLCB4 PIK3CA PLCB3 PLCB1 PLCB2 TSC2 AKT3 PIK3CD TEAD2 LATS1 PKN2 LATS2 TEAD3 TEAD4 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260410%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling MMP9 SLPI PTEN MST1R SMAD6 DUSP4 PIK3R1 SMAD2 SOCS3 SOCS1 RPS6KA3 PCNA KDR MTOR PLCG1 HK2 RPS6KB1 SMAD1 FGFR1 ITGB1 FLT1 ACACA SMAD9 CLDN5 CXCL1 TGFB1 IGF1R CXCL5 RPS6KA1 DKFZp781O1323 PDPK1 GSK3B PPARGC1A TNF MAPK8 HEL-S-133P IFNB1 CLDN1 IL10 HEL-S-102 CXCL2 PARP1 PRKAA2 CXCL8 TJP1 CCL2 MAPK1 FOS HEL113 MAPK3 IL6 SNAI2 JUN MAP2K1 MAP2K2 NFKB1 MAPK14 CSF3 CSF2 IBSP ACTA2 BGLAP GRB2 RAF1 CDH2 PDGFRA COL4A1 SP7 CRKL PRKCB FZD1 SIX1 RPS6KA4 CTNNB1 RPS6KA5 WNT10B ZEB2 SRC KLK15 IL1B CPT1A RELA RPS6 MAPK9 EGR1 NR0B2 VEGFA GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260410%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids DGAT1 PTDSS2 PTDSS1 DGAT2 CDS1 CHKB PCYT2 ETNK1 PEMT CHPT1 GPAM PNPLA2 DGKZ GPAT4 PISD PNPLA3 AGPAT4 PLA2G1B CDIPT ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260410%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome LMNA RCE1 FNTA HEL-S-62p ICMT LMNB2 CFD CELL CYCLE%WIKIPATHWAYS_20260410%WP179%HOMO SAPIENS Cell cycle CDK6 CHEK2 MYC SMAD2 CCNH CDC14B CDKN2B HEL2 CDC20 CDC23 PTTG1 PLK1 PTTG2 CDC2 CDC27 CDC25B ANAPC7 ANAPC5 ANAPC2 CDK4 ANAPC13 PKMYT1 CDKN2C ANAPC10 ANAPC11 ORC6 CDC6 ORC3 ORC2 STAG2 SMC1B DBF4 FZR1 CDKN2D WEE2 ANAPC1 CCND3 RBL2 MCM7 YWHAZ CDKN1A RBL1 YWHAQ E2F5 EP300 MCM3 MCM5 MCM6 CDKN2A CCNE1 CDK2 MDM2 STAG1 MAD1L1 CCNB1 WEE1 CDK7 RBX1 PCNA MAD2L2 TGFB1 ORC1L HDAC2 HDAC1 RB1 TFDP1 PRKDC TFDP2 E2F2 GSK3B TTK E2F3 CCNB2 HEL-S-1 CCND1 CDKN1C SMAD4 SKP2 SKP1 GADD45B ESPL1 GADD45A GADD45G CCND2 SFN CHEK1 YWHAG ATR CCNB3 E2F4 MCM2 CCNE2 RAD21 ATM CDC45 SMC3 SMC1A CDKN1B CCNA2 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260410%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM BLM CHEK2 ATF2 YAP1 BRCA2 CHEK1 PCNA RASSF1 H2AX BAK1 ATR RAD9A TRIM28 CDKN2A BAX FANCD2 MDM2 MCPH1 RIF1 MDC1 RNF8 RAD50 CDK5 MRE11A ATM BRCA1 NBN PRKDC SMC3 TP53BP1 TP73 SMC1A CASP9 TERF2 RAD51 RAD52 HSF1 RAD17 ACTL6A CASP3 LATS1 NABP2 KAT5 PARP1 APAF1 TRAF6 ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2858%HOMO SAPIENS Ectoderm differentiation MYC TCF3 SOX2 SDCBP MKS1 GAS2L1 HDAC10 KRT6A KCNK10 POU2F2 MZF1 ASTN1 LY6E TFAP2C ARX STC1 ARHGAP15 ZBTB2 TRPM2 RHPN1 ST8SIA4 HESX1 ZBTB7B SHH SKIL GREB1 PRKAG2 PAN2 PTPRB PPFIBP2 MAFB LDB2 PLXNA2 WDR44 SIX6 GLI3 UBTF RAB8B BCAS3 SORCS1 BAZ1A FOXL1 SERPINB6 ARHGAP10 ARHGEF9 KIFC3 BMP4 RUTBC3 STX16 RRBP1 CLVS1 CAP2 GLB1 TTC14 TNLG7C C1GALT1 VAX2 RIT1 ZNF219 CTNND2 MYORG BOC CTNNA2 PTPN13 RGMA CELSR2 DMD CDH8 CDH6 GATA6 TNFRSF11B H2BC9 ARHGDIG JUP FZD4 PIM1 ZFHX4 LHX1 CDON NUMA1 SMURF1 SCHIP1 PAX3 PAX6 TOX3 FYN NF2 OGT SOCS2 ZBTB16 SPRY2 BCOR FOXA2 NFATC1 CLDN11 HMGB2 AHI-1 NLGN1 SMAD4 FHL2 ELOVL4 CCL2 ROR2 CTBP1 SNCA PDE7A NLK NR2F2 NR1C2 WNT1 ELOVL2 TLE5 TFAP2A CTNNB1 TCF7L1 FZD5 FGFR2 TBL1X HDAC6 FZD8 BMPR1A SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260410%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism FADS1 ALOX5 FADS2 ACSL1 CYP4F3 TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260410%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells MAP2K5 PIK3R2 PIM2 PIK3R1 EIF4EBP1 EIF4A2 EIF4E EIF4B CSNK2A1 MAPK1 MTOR MAP2K6 MAPK3 RPS6KB1 EIF4G1 MAP2K3 MAP2K4 PIK3R3 MAP2K1 RPS6KB2 MAP2K2 MAPK14 PIK3CA MAPK10 RPS6KA1 EIF4A1 AKT3 MAPK8 PIM1 RPTOR RPS6KA2 RPS6KA4 PRKCA RPS6KA5 MAPK9 RPS6 LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260410%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH NONO MDH2 NMRK2 CS SLC19A2 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260410%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease BBC3 NDUFB9 PRKAA1 NR1H3 PRKAB2 NR1C1 PRKAB1 DDIT3 PIK3R3 PIK3CA ADIPOR2 PRKAG1 PRKAG2 PRKAG3 COX4I2 CYP2E1 CXCL8 IKBKB NDUFA11 COX6A1 MAP3K5 COX6A2 COXFA4L2 NDUFC2-KCTD14 COX6B2 COX6B1 COX7A2L ERN1 UQCRC1 COXFA4 IL6 UQCRC2 UQCRB COX7A2 JUN COX7A1 UQCRH COX3 LEPR CYC1 ADIPOR1 COX7B2 UQCRQ COX7B COX4I1 ATF4 COX7C NDUFA9 CYB NDUFA5 MLX COX8A COX8C NDUFS8 UQCR11 UQCR10 COX5A NDUFA13 MLXIP IRS1 UQCRHL MLXIPL PIK3CD VCAM1 RAC1 IL1B PKLR NR1H4 NDUFA10 COX2 PIK3R2 PIK3R1 SOCS3 INS CDC42 INSR BCL2L11 ITCH MAP3K11 CEBPA SDHC SDHD SDHA SDHB TGFB1 LEP GSK3B TNF AKT3 MAPK8 CASP8 TRAF2 CASP3 NDUFA12 GSK3A EIF2S1 NDUFC2 NDUFC1 NDUFS6 IL1A NDUFS5 TNFSF6 NDUFS4 PRKAA2 NDUFS3 NDUFS1 FAS CYCS NDUFB8 NDUFB7 CCL2 NDUFB10 BAK1 NDUFB6 NDUFB5 NDUFB11 XBP1 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFV3 RXRA NDUFV2 BAX NDUFA7 NDUFA6 NFKB1 ZNF183 IL6R TNFRSF1A NDUFA3 NDUFA2 NDUFAB1 UQCRFS1 RELA MAPK9 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260410%WP536%HOMO SAPIENS Calcium regulation in cardiac cells CAMK2G ATP2B1 CHRM2 HEL2 PRKAR1B PRKAR1A ADCY9 ANXA6 CACNB1 ITPR2 ORAI1 GRK5 CASQ1 GRK4 CACNA1S GNG12 GNG11 GNG13 RYR2 GNB2 GNAI3 GNB4 ADCY3 GNB3 GNAI1 GNB5 GNG2 YWHAZ GNAO1 GNGT1 GNB1 GNAS PRKD1 ATP2A2 CAMK1 YWHAQ ADCY1 ADCY8 ADCY6 GNG3 CACNA1C GNG5 GNG4 ATP1B1 GNG7 GNG8 FXYD2 RYR3 RYR1 ADRB2 CALM1 PLCB3 SLC8A1 CAMK4 RGS4 GJA1 RGS5 GJA3 RGS1 GJA5 GJA4 GJA9 GJA8 RGS6 RGS7 ATP1B3 ATP1B2 CACNB3 STIM2 CACNA1B CACNA1A GJC1 PKIB CHRM3 GJB2 CHRM1 GJB1 CHRM4 GJB4 CHRM5 GJB3 PKIA ADRB1 PKIG GJD2 CASQ2 PRKCZ RGS18 RGS17 RGS14 RGS16 ATP1A4 RGS20 KCNJ5 KCNB1 ATP2B3 ADRB3 CXNO ATP2B2 CXNA RGS11 RGS10 GJB6 FKBP1A HEL-S-1 ARRB2 RGS2 PRKCQ PLN SFN YWHAG GNAZ ADRA1D ADRA1B ADRA1A KCNJ3 PRKCH PRKCB PRKCE PRKCA HEL-S-99n CAMK2D CAMK2A GNA11 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism B3GNT5 FUT2 FUT1 FUT3 B3GALT2 B3GALT1 HEPATITIS B INFECTION%WIKIPATHWAYS_20260410%WP4666%HOMO SAPIENS Hepatitis B infection MYC SMAD2 IFIH1 BAD MAVS VDAC3 RIGI PIK3R3 ATF6B PIK3CA YWHAZ CDKN1A MAPK13 YWHAQ ATF2 EP300 CXCL8 IKBKB ARAF IKBKG NRAS MAPK1 FOS HRAS MAP2K6 MAPK3 IL6 MAP2K3 MAP2K4 JUN MAP2K1 MAP3K1 MAP2K2 BRAF CREBBP MAPK14 MAPK12 MAPK10 ATF4 GRB2 KRAS SOS1 RAF1 SOS2 CREB3L3 CREB3L4 CREB3L2 IF1AA9 PIK3CD JAK1 CREB3 DDB2 TYK2 CREB5 CREB1 MMP9 IFNAR1 PIK3R2 NFATC2 PIK3R1 IFNA13 IFNA14 IFNA16 IFNA17 STAT4 PCNA IFNA10 STAT1 STAT2 STAT3 IFNA21 HSPG2 DDB1 IFNA1 BIRC5 TGFB1 NFATC1 TNF HEL-S-1 AKT3 CASP9 MAPK8 CASP8 TBK1 IRAK1 CASP10 CASP3 IKBKE CHUK SMAD4 IFNB1 FADD MAP3K7 IRAK4 TICAM1 TIRAP TGFBR1 TGFBR2 MAP3K7IP1 IRF3 APAF1 TRAF3 NFATC4 TRAF6 IRF7 NFATC3 TLR4 TNFSF6 MYD88 DDX3X BCL2 IFNA4 FAS CYCS IFNA7 IFNA6 IFNA2 IFNA8 BAX NFKB1 EGR2 TICAM2 TLR3 JAK3 CASP12 MAPK11 PRKCB PRKCA SRC RELA MAPK9 PTK2B STAT5B MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260410%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 ERBB2 GJB2 ERBB4 EGFR MYC USF1 ERBB3 PRLR EIF4E CSN2 CEBPA EIF4G1 CEBPB CLDN6 DLGAP4 TFPI2 BCL2L1 USF2 TTC9 TPM3 GAL NFIB ORAI1 HDGFL2 NR3A2 NR3C1 PTPN1 YY1 TNFSF11 CCND1 NRG1 PGR NFIA PRL CHUK ELF5 TNFRSF11A STAT5B NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260410%WP4747%HOMO SAPIENS Netrin UNC5B signaling IL1A NTN1 SELE ROBO4 YAP1 CCL2 FYN INPP5D ARHA KDR MAPK1 ALPL PTPN11 RGMA COL1A1 MAPK3 NTN3 JUN PTPA MAP2K1 ITGB4 MAP2K2 MAPK14 CTGF PIK3CA RLF PLEKHH1 UNC5B CIP2A NEO1 DCSTAMP MYF5 PPP2R1B RAF1 TNF PRKCA ARHGEF12 SRC CASP3 RAC1 VCAM1 AGAP2 PTK2B IL10 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260410%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease SP1 KCNN3 CALM1 SP3 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260410%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGF PIGS PIGU PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 PIGP PIGW PIGV PIGY PIGX PIGC DPM2 PIGB PIGA PIGK PIGM MPPE1 PIGL PIGH BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260410%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation DYNC1H1 NUDC HEL-S-303 TUBA1A PAFAH1B1 RELN DCX NDEL1 VLDLR IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260410%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia KIT ABCB1 GADD45A BCR MYC PIM2 ABCG2 PDGFRA CDKN1B LYL1 PIM1 FOXO3A CSF1R SKP2 GAB2 FLT1 NOP2 RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260410%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR EGFR KRAS PTGS2 AKT3 PIK3CD NRAS MAPK1 PTGER4 PTGER1 SRC HRAS PTGER2 PTGER3 MAPK3 BRAF PIK3CA PLA1A INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260410%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNC2H1 IFT140 IFT80 DYNLT3 WDR35 IFT43 IFT25 IFT22 DYNC2I2 DYNLT1 IFT81 DYNC1I1 DYNC1H1 IFT27 DYNLL2 DYNLRB2 IFT46 DYNC1LI1 DYNC1LI2 DNCL1 DYNLT2B DYNC2LI1 GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260410%WP2361%HOMO SAPIENS Gastric cancer network 1 INO80D UBE2C CENPF TOP2A HCTP4 LIN9 GATD3 H4C9 KIF15 SMOC2 ESM1 MYBL2 ECT2 KIF20B RUVBL1 AURKA NUP107 E2F7 ACTL6A S100P NOTCH1 H3F3B CEP192 APC LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260410%WP3965%HOMO SAPIENS Lipid metabolism pathway PRKAA2 LIPE HILPDA PRKAG1 ABHD5 AKT3 PRKAG2 PLIN1 PNPLA2 PRKAA1 PRKACG PRKAG3 PRKAR1B PRKAR1A PRKAB2 PRKAB1 ACSS2 PDHA1 FASN ACACA ACLY ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260410%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk KDR SRC RAC1 ROBO4 SLIT2 VEGFA 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260410%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb CDC2 PRKAA1 MTOR PRKAB2 RPS6KB1 PRKAB1 CDR2 RPS6KA1 PRKAG1 PRKAG2 PRKAG3 EEF2K EEF2 CDH18 MAPK13 PRKAA2 NDUFS3 RAB5IF MOSMO TRPM7 PDZD9 MAPK1 SDR42E2 VWA3A POLR3E UQCRC1 MAPK3 COXFA4 UQCRC2 UQCRB MAP2K1 CDK2 UQCRH MAP2K2 CYC1 MAPK14 MAPK12 UQCRQ CALM1 COX7C NDUFA9 CYB NDUFS8 UQCR11 UQCR10 COX5A MAPK11 RPTOR MLST8 UQCRFS1 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260410%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP H3C15 CDK6 UBE2D1 H4C9 HIST1H4L CDKN2B CDC23 RPS6KA3 CDC27 ANAPC7 UBB ANAPC5 ANAPC2 CDK4 CDKN2C STAT3 ANAPC10 UBC ANAPC11 HIST1H2AB UBE2S CEBPB FZR1 CDKN2D ANAPC1 H2BC15 RPS6KA1 RPS27A CDKN1A IL1A UBE2C CXCL8 MAPK7 H2AX MAPK1 FOS CDKN2A CDC26 VENTX MAPK3 ANAPC15 IL6 C10orf104 IGFBP7 JUN EHMT1 CDK2 NFKB1 H2AC19 H2AC14 H2BC26 H2BC12L H2BC21 H2BC9 H2BC8 H2AC6 UBE2E1 CDKN1B H2BC3 H2BC1 H2BC17 RPS6KA2 H2BC12 H2BC13 H2BC14 H2AC20 H2BC11 CCNA2 HIST1H2BE RELA H2AZ1 H2AZ2 H3C8 H3F3B H2AB1 H2AJ EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260410%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway EPHX2 CYP4F12 CYP4A11 NR1C1 PPARG CYP2C8 CYP4F2 CYP4A22 CYP2C18 METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260410%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts ALDH18A1 CD36 PHGDH GLUD1 HEL-S-133P PSPH ARHA GLS UGDH FGFR4 BMP1 GCK PLCG1 P4HA2 FGFR1 P3H4 PLOD1 PSAT1 P3H3 LPAR1 LOXL2 ADAMTS2 P4HA1 P4HA3 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260410%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway OXSM HTD2 MCAT MECR ACACA HSD17B12 BURN WOUND HEALING%WIKIPATHWAYS_20260410%WP5055%HOMO SAPIENS Burn wound healing FOXE1 MMP2 MMP9 BRD4 PECAM1 INHBA CXCL12 FGFR4 COL1A2 DCN FGFR1 CHRNA7 IL8RB KRT6A CXCL1 HMGB1 S100A6 TNF TIMP1 CASP3 IFNB1 HGF ACTA1 TLR4 MYD88 FGFR3 ACHE BCL2 CXCL8 NOX4 F13A1 IFNA2 CCL2 IL15 COL1A1 CD3E MMP28 EGF IL6 SNAI2 BAX NFKB1 HEXD DKFZp686P11128 KRT222 KLF4 S100A9 FST PCTK1 FLG SCEL AMBP HEL-S-43 SLURP1 LIN28A TPT1 IL1B FGFR2 CXCR4 TNC VEGFA FBN1 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260410%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling MAPKAP1 PTEN SMAD2 IGFBP5 MAP1LC3A EIF4E ACVR2B MTOR RPS6KB1 PRKAB1 TNLG5A ITGB1 NFKB1 TNFRSF1A GDF8 HEL-S-28 IGF1R DEPTOR GSK3B PPARGC1A IGF1 IRS1 RPTOR TRIM63 FBXO32 WASL MLST8 AKT1S1 RICTOR EIF2B2 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling PLK1 MAP3K8 CISH PIK3R3 PIK3R5 PIK3CA CXCL11 CXCL9 MAPK13 CXCL8 IKBKB IKBKG CCL3 MAPK1 FOS MAP2K6 MAPK3 IL6 MAP2K3 MAP2K4 JUN MAP2K1 MAP2K2 MAPK14 MAPK12 MAPK10 ZMYND11 IF1AA9 PIK3CD MLST8 RAC1 IL1B IFNAR2 MBL2 IFNAR1 SMAD6 PIK3R2 PIK3R1 IFNA13 IFNA14 IFNA16 IFNA17 SOCS1 IFNA10 STAT1 IFNA21 NFKB2 PTPN6 IFNA1 IRAK2 TNF RNF41 AKT3 TNFAIP3 TREM1 MAPK8 CASP8 SYK TBK1 IRAK1 IKBKE CHUK IL12B IFNB1 IL12A FADD IRAK3 MAP3K7 IRAK4 TICAM1 TLR1 BTK TIRAP TIFA NFKBIA TLR9 TLR8 MAP3K7IP1 IRF3 TRAF3 TLR7 TRAF6 IRF7 TLR5 TLR4 OTUD5 MYD88 SQSTM1 IFNA4 CYLD IFNA7 IFNA6 IFNA2 CCL5 IFNA8 CCL4 TMED7 RBCK1 NFKB1 RIPK1 CD40 CD80 LBP TICAM2 TLR3 LY96 SPP1 CD14 TAB3 MAPK11 FBXW5 CD180 TRAFD1 SIGIRR CUEDC2 SFTPD RELA PELI1 MAPK9 RNF31 SFTPA2 PELI3 SARM1 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260410%WP3972%HOMO SAPIENS PDGFR beta pathway GRB2 PIK3R1 SOS1 RAF1 EIF2AK2 MAPK8 PRKCB STAT1 PRKCA STAT3 FOS HRAS PLCG1 JAK1 MAPK3 MAP2K4 JUN MAP2K1 STAT5B MAP3K1 PIK3CA 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260410%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome MARF1 DCP1A ACTR10 PLAGL1 ABCC1 DCP2 RAPGEF4 RAP1A PLK1 OFD1 CEP20 PAFAH1B1 DISC1 KIAA0753 GATA3 DCTN6 DCTN1 DCTN4 PLAG1 PCM1 CEP170 ACTR1B BMERB1 NDE1 ABCC6 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260410%WP1422%HOMO SAPIENS Sphingolipid pathway CERK PLPP1 SGMS1 SPHK2 SPTLC1 SPHK1 ASAH2 SGMS2 GBA2 SGPP2 ACER1 SPTLC3 UGCG SPTLC2 SERINC1 SGPL1 CERT1 KDSR CERS5 UGT8 CERS6 CERS2 PPP2CA CERS3 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260410%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway FGF7A KIT WNT2B INHBA INS NTF4 LEFTY1 IL3 KITLG FLT3LG EGF IL6 ALK FGF10 DKK1 FGF2 IL6R TGFB1 NT5E TF CSF1 FGF8 TNFSF11 EPO NOG FST IGF1 PDGFA SHH CNTF WNT1 CXCR1 CSF1R NOTCH1 WNT3A IL11 HGF WNT7B GDF5 NODAL TPO VEGFA BMP4 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260410%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma MTOR AKT3 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260410%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation PTEN MAPKAPK2 ROCK1 NTRK3 CDC42 LIMK1 CDC2 TAOK1 MAPRE1 PHLDB2 TRIO MAP1B NTRK1 NTRK2 STAT3 CFL2 F2RL2 TIAM1 MARK1 PARD6A GSK3B DVL1 CAMK4 PAK1 RHO FREP1 EPHB2 PRKCA AURKB SRC RAC1 SPRED1 WNT3A CLASP1 APC HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260410%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway KEAP1 SLC11A2 PRKAG1 PDHA2 HEL-S-133P PRKAA1 HIF1A PRKAB1 RPS6 PDHA1 ACACB ACACA NFE2L2 EGLN1 VEGFA CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260410%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis CD8B1 CALM1 HDAC2 NFATC2 HDAC1 EP300 PPP3CC ITPRIP MEF2D CABIN1 CD8A PLCG1 ATP2A1 PPP3CA ZAP70 LCK JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members HDAC3 PARP11 STAT3 DTX3L BTRC HDAC2 PARP14 SKP1 RBX1 PARP1 STAT1 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260410%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders FGF7A WWTR1 H4C9 HIST1H4L SOX2 SOX4 SOX11 POU3F2 SRRT SOX12 TEAD2 POU3F1 UTF1 SOX15 ZSCAN10 YES1 METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260410%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 WNT SIGNALING%WIKIPATHWAYS_20260410%WP428%HOMO SAPIENS Wnt signaling CAMK2G NOTUM MYC PPP3CC DAAM2 PRICKLE2 GPC4 PLCB4 PLCB1 CCND3 PLCB2 VANGL1 PPP3R2 DAAM1 ROCK2 JUN PPP3CA PORCN LRP5 LRP6 PLCB3 RAC1 LEF1 NFATC2 ARHA PPP3R1 NFATC1 GSK3B CCND1 MAPK8 WNT3A MAP3K7 AXIN1 DKK4 NFATC4 APC NFATC3 WNT2B CHD8 FZD10 FRAT1 FRAT2 CCND2 SOX17 SOST CER1 INVS WNT5B CSNK2A1 CSNK2A3 CSNK2A2 CTNNBIP1 KREMEN1 CSNK1E WNT16 SENP2 DKK1 DKK2 SFRP4 SFRP1 SFRP5 CSNK2B ROR1 ROR2 CTBP2 CTBP1 NLK CXXC4 NKD1 NKD2 WIF1 DVL1 DVL2 DVL3 WNT1 PRKCB WNT3 FZD1 PRKCA CTNNB1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 FZD5 MAPK9 WNT4 CSNK1A1 CAMK2D RYK WNT7B FZD7 CAMK2A FZD9 WNT7A FZD8 FOSL1 ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5393%HOMO SAPIENS Androgen biosynthesis POR HSD3B2 CYP3A7 HSD17B1 HSD17B2 HSD3B1 HSD17B3 HSD17B4 HSD11B1 HSD11B2 SULT2A1 SRD5A2 CYP17A1 AKR1C1 AKR1C2 AKR1C4 CYP3A4 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260410%WP727%HOMO SAPIENS Monoamine transport and regulation SYN1 ACHE TPH2 DBH ADORA2A SLC6A2 SLC6A3 HRH3 MAPK14 SLC5A7 AMPH IL1R1 NECTIN2 TDO2 SLC6A1 TNFRSF11B ITGB3 TGFB1I1 TNF RBL2 TSC2 FBXO32 STX1A IL1B UNC13B TH IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260410%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling IL1A STAT2 STAT3 HEL-S-10 JAK1 IL6 IL10RB IL10RA IL10 HMOX1 STAT1 OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260410%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence SLCO2A1 ALOX5 PTGS2 ALOX15B DECR1 PTGES3 ALOX5AP FADS1 SIRT1 PTGIS PTGS1 ALOXE3 AKR1B1 EPHX2 CYP4F8 HEL-S-53e NAT2 PTGES PRXL2B RB1 HEL-S-298 HPGD ALOX15 FADS2 ALOX12 ELOVL5 GPX1 ELOVL2 MAPK11 LTC4S HEL-S-22 CDKN1A DPEP2 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260410%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors LAMC1 LAMA4 XB SDC2 COL4A2 COL4A1 ITGA1 THBS2 COL1A2 COL3A1 COL5A3 LAMB2 COL5A2 ITGB5 THBS1 COL6A1 ITGB6 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260410%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCC CYB UQCC3 UQCC2 UQCR11 UQCR10 TTC19 LYRM7 UQCRC1 UQCRFS1 UQCRC2 UQCRB UQCRH CYC1 UQCRQ GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260410%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation NFATC1 PLCB3 PRKCZ PPP3CC PRKCH PRKCB PRKCE PRKCA PRKCI ANGPT2 PKN2 PRKCQ PRKD3 PKN3 PPP3CA PKN1 PPP3R2 PPP3R1 PRKD2 PRKD1 PDGF PATHWAY%WIKIPATHWAYS_20260410%WP2526%HOMO SAPIENS PDGF pathway PIK3R1 CDC42 STAT1 ARHA MAPK1 STAT3 PTPN11 FOS HRAS TIAM1 PLCG1 MAPK3 MAP2K4 JUN MAP2K1 MAP3K1 NFKB1 GRB2 SOS1 RAF1 PDGFA MAPK8 PAK1 WASL SRC RAC1 JAK1 CHUK VAV1 NFKBIA COX2 VAV2 UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260410%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups ALDH18A1 HEL-S-20 HEL-S-29 GLUD1 ARG1 HEL-S-5 ASL NAGS ASS1 SMS SRM OTC ARG2 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260410%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II SULT1C3 SULT1C2 SULT1B1 SULT6B1 UGT1A10 SULT1A4 SULT1A2 UGT1A9 SULT1C4 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT1A5 UGT2B4 UGT2A2 UGT2A1 CYP4F8 NAT2 NNMT TPMT INMT HEL-S-75 CYP4Z1 CHST6 CYP2U1 CYP4F22 CYP4X1 CHST10 NAA50 CHST11 CYP2J2 GATF-C GLYATL2 CYP4F11 CYP27C1 AKR1B10 NAT8 CYP2S1 CYP11B2 NAT9 NAA40 CYP21A2 NAT10 AKR1C1 NAT14 AKR1C2 LOC51064 AKR1C4 CYP4V2 CYP3A4 HYAL3 GSTM1 CYP2R1 GAL3ST3 UGT1A3 FMO4 EPHX1 GAL3ST4 FMO5 CHST8 CYP1B1 CYP2E1 CHST9 KCNAB1 KCNAB3 CYP2A7 CHST4 CHST5 NAA20 CYP2F1 HS3ST5 HS3ST6 HS3ST4 GSTZ1 CYP1A1 CYP20A1 CYP46A1 SULT2A1 CYP3A43 UGT1A4 CYP2A6 AKR1B1 SULT2B1 SULT1A1 UGT1A1 GSTM4 GSTM3 GSTM2 GPX2 GSTM5 GPX4 GPX3 CYP3A7 CYP51A1 HEL-75 CYP26C1 CYP27B1 GSTT2 CYP24A1 CYP17A1 GAL3ST2 NAT8L HS3ST3A1 EPHX2 HS6ST1 HS6ST2 HS2ST1 HS6ST3 CHST12 NDST3 BAAT CHST13 CHST14 CYP7B1 HS3ST3B1 CYP8B1 CYP27A1 CYP11A1 CHST7 UGT1A7 HS3ST1 HS3ST2 MGST3 CHST1 CHST3 MGST1 CYP4F3 MGST2 GSTT2B CYP2C9 CYP2C8 CYP2B6 CYP2C19 CYP2C18 HEL-S-75p CYP26A1 CYP26B1 CYP7A1 GSTA5 GSTA4 GSTA3 CYP2W1 HEL-S-166mP CYP2A13 CYP4B1 CYP4F2 HEL-S-64p CYP4F12 HEL-S-21 HEL-S-22 SULT1E1 UGT2B7 HEL-S-165mP SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260410%WP1455%HOMO SAPIENS Serotonin transporter activity IL1R1 STX1A IL1B TPH2 ITGB3 TGFB1I1 MAOA PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260410%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS NCK1 TLN1 VTN PCNA FYN CTSL SCARB2 CD151 PTPRO PLCE1 PARVA LMX1B PLCG1 SYNPO ITGB1 TRPC6 ITGB4 PAX2 CD2AP MYO1E HEL-S-28 INF2 TGFB1 NPHS1 NPHS2 MYH9 IRF6 FAT1 ITGAV CDKN1C CDKN1A CLDN1 MME TLR4 LAMA5 YWHAQ SMARCAL1 MKI67 AGRN KIRREL3 KIRREL2 HEL113 PLAUR LIMS1 LAMB2 DKK1 LRP5 LRP6 ACTN4 CD80 ITGB3 CDH2 CDKN1B WNT1 COL4A4 DAG1 COL4A3 WT1 CTNNB1 COL4A5 NOTCH1 HEL114 CR1 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260410%WP2646%HOMO SAPIENS Lidocaine metabolism CYP3A4 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260410%WP1601%HOMO SAPIENS Fluoropyrimidine activity DPYS DPYD UMPS TYMP DHFR CES2 ABCG2 CES1 CDA FPGS TYMS UPP2 SLC22A7 TK1 ABCC5 GGH UCK2 CYP2A6 UCK1 XRCC3 ABCC3 TDG RRM2 ERCC2 SMUG1 SLC29A1 RRM1 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260410%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC PRKAA2 RHOD RHOB MOB1A YAP1 PRKAG1 PRKAG2 RHO ARHA PRKAA1 PRKAG3 PRKAB2 LATS1 TEAD2 STK4 LATS2 HMGCR PRKAB1 TEAD3 TEAD4 CYR61 CTGF GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260410%WP4521%HOMO SAPIENS Glycosylation and related congenital defects SRD5A3 ALG2 ALG14 ALG13 ALG3 DOLK ALG12 ALG11 DPM1 GMPPB DPM3 MGAT2 GCS1 MPDU1 MAGT1 TUSC3 DPM2 ALG1 DPAGT1 ALG8 ALG9 B4GALT1 ALG6 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260410%WP3996%HOMO SAPIENS Ethanol effects on histone modifications HDAC3 CYP2E1 ATF2 HDAC7 DHFR HDAC5 TYMS ACSS2 HDAC10 ADH1A HDAC2 HEL-S-53e HDAC1 MTR MAT1A ADH1C ALDH1A3 HEL-S-117 HAT1 ALDH2 KAT2B HDAC8 ALDH1A2 HDAC9 HDAC6 SLC19A1 S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260410%WP26%HOMO SAPIENS S1P receptor signal transduction S1PR2 PLCB3 S1PR5 PLCB1 SPHK2 PLCB2 SPHK1 MAPK7 PIK3C2B GNAI3 GNAI1 AKT3 S1PR3 MAPK1 MAPK4 MAPK3 SMPD2 S1PR1 MAPK12 MAPK6 UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260410%WP4595%HOMO SAPIENS Urea cycle and associated pathways GOT2 SLC25A12 HEL-S-32 GLUD1 NOS2 SLC25A15 LDHB GLS2 ARG1 ASL NAGS ASS1 SLC25A13 FH GPT OTC MDH2 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260410%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 FBL MAFG IRF2 HEL23 SMAD4 FOXO1 PCNA CREB1 NPAS2 CREBBP DDX21 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members ARAF MAP3K10 MAP3K5 MAPK1 MAP3K8 MAP2K6 MAPK3 MAP3K11 MAP2K3 MAP2K4 MAP2K1 MAP3K1 MAP2K2 BRAF MAPK14 MAPK12 TNKS MAPK10 ATF4 PARP14 RAF1 MAP3K12 MAPK8 MAPK11 MAP3K21 MAPK9 MAP3K7 PARP1 MAPK13 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260410%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases D2HGDH HEL-S-5 GCDH ADHFE1 L2HGDH MDH2 ALDH7A1 BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260410%WP5031%HOMO SAPIENS Biotin metabolism including IMDs MCCC2 BTD PCCA HLCS ACACB MCCC1 ACACA PCCB PC HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260410%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis SIAH1 HIPK2 STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260410%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling SAR1A CDK8 RNF139 SEC23B SEC31B SEC31A AMFR SEC24C INS CAMP SP1 PRKAA1 HMGCS1 MTOR PRKAB2 PRKAB1 HMGCR MED15 SREBF2 SCD FASN ACACA ACLY SAR1B PIK3CA PPARG HEL-S-32 SEC23A PPARGC1B PRKAG1 PRKAG2 PRKAG3 GSK3A NFYA LPL PRKAA2 SCARB1 DBI FGF21 LDLR SIRT1 INSIG1 ACSS1 NR1H2 YY1 IDI1 MBTPS1 FDPS GPAM CYP51A1 SQLE MVD MBTPS2 LPIN1 FDFT1 CREB1 RBP4 CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260410%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism NAT2 XDH CYP2A6 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260410%WP2290%HOMO SAPIENS RalA downstream regulated genes EXOC8 EXOC2 RAC1 HRAS KRAS YBX3 RALA CDC42 RAC3 NRAS RALBP1 METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer SLC16A4 LDLR PDHX GLUD1 BCAT2 GFPT1 PGM3 HK2 SOAT1 HMGCR GNPNAT1 FASN ACLY CS CARM1 RPIA RPE PFKL KRAS GOT2 DLD ME1 HEL-S-32 HEL-S-30 HEL-S-133P GLS2 DLAT GPT PDHA1 SLC7A5 NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260410%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway NOD1 NLRC4 IKBKB NAIP MEFV CASP5 IKBKG NLRP7 NLRP2 NLRP1 AAMP CARD8 CARD9 DUOX2 CARD6 ACAP1 AIM2 NLRP10 ERBIN NOD2 PRDM1 PYCARD NLRP12 COPS6 NDUFA13 IL18 CASP9 CASP8 RAC1 CHUK IL1B RELA NFKBIA NLRP3 RIPK2 NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260410%WP5572%HOMO SAPIENS Nucleosome remodeling complex ASF1A CHEK2 SUPT16H H4C9 HIST1H4L PRKDC SSRP1 SMIM40 RBBP4 NASP PCNA CHAF1A HAT1 XRCC5 CHAF1B ASF1B MCM2 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP560%HOMO SAPIENS TGF beta receptor signaling SMAD6 SMAD2 INHBA STAT1 RUNX3 STAT3 SMAD1 ZFYVE9 BAMBI ITGB6 SMAD9 TGFB1 DKFZp781O1323 FKBP1A ZNF423 TNF SKIL SMAD4 TGFBR1 TGFBR2 LIF TGFBR3 BMP4 EP300 SKI LEFTY1 LEFTY2 FOS HRAS MAPK3 EGF THBS1 RUNX2 JUN FOXH1 NFKB1 CREBBP NOG FST SPP1 WNT1 TGIF1 CTNNB1 ZEB2 JAK1 IFNG LEF1 MAPK9 LTBP1 ENG NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260410%WP2064%HOMO SAPIENS Neural crest differentiation RBPJ GJB1 HES5 DLX5 TBX6 MYC PAX3 MSX2 HAND1 NOTCH2 NOTCH3 NFKB2 SMAD1 ZIC5 FGFR1 ITGB1 HDAC11 HDAC10 DMBX1 FOXD3 MSX1 MIA OLIG3 BMP7 SOX10 TFAP2B PHOX2B ZIC1 DCT HOXB1 HDAC2 PRTG HDAC1 LHX5 PAX7 NEUROG1 GSK3B COL11A2 GBX2 FGF8A WNT3A AXIN1 ASCL1 HDAC9 ISL1 GFAP BMP4 TCF4 HDAC3 COL2A1 RHOB SNAI1 MPZ FGFR3 PMP22 HDAC7 ID1 HDAC5 TLX2 OLIG1 OLIG2 TWIST1 MBP AXIN2 SNAI2 HOXA1 FGF2 NFKB1 CDH6 CTBP2 FGF8 CDH2 SOX5 DVL1 DVL2 DVL3 MYB WNT1 HEY2 TFAP2A CTNNB1 SOX9 HDAC8 FZD3 LHX1 TCF7L1 NOTCH1 FGFR2 WNT8A DLL3 HDAC6 DLL4 HES1 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260410%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists NR1i2 SCARB1 NR1C1 CD36 CYP2C9 NR1C2 NR1i1 NPC1L1 INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260410%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment TGFB1 TLR4 CD80 IL2RG IL4 SOCS1 CCL5 CCL2 IL2RA IL2RB STAT3 CTLA4 NFKB2 IRAK4 PDCD1 TGFBR2 TLR8 NFKB1 TLR7 TRAF6 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260410%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism FFAR3 GCG SLC2A4 PYY FFAR2 NR1C2 RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260410%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation CXCL8 IKBKB IKBKG PLCG2 MAPK1 PLCE1 PLCG1 MAPK3 IL6 RETN NFKB1 MAPK14 PLCB4 PIK3CA PLCB3 PLCD3 PLCB1 PLCB2 PLCD4 TNF AKT3 PIK3CD CHUK IL12B RELA IL12A NFKBIA AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260410%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension HAL UROC1 GPT2 FTCD GLUD1 FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260410%WP143%HOMO SAPIENS Fatty acid beta oxidation LPL ECHS1 LIPE ACADL GPD2 ACSL3 DECR1 ACSL1 ACSL6 ACSL5 PNPLA2 ACSS2 LIPC FACL4 ACADVL LIPF ACADS CHKB DLD ACAT1 CRAT CPT2 SLC25A20 HADHB GCDH ACADM CPT1A HEL-S-49 IL4 SIGNALING%WIKIPATHWAYS_20260410%WP395%HOMO SAPIENS IL4 signaling PIK3R2 ATF2 PIK3R1 EP300 CBL SOCS3 SOCS1 BAD IKBKB INPP5D STAT1 MAPK1 STAT3 PTPN11 FOS MAPK3 RPS6KB1 CEBPA PTPN6 CEBPB NFKB1 MAPK14 PIK3CA FES GRB2 SOS1 IL2RG FLNA IL4 JAK3 IRS1 PIK3CD SOCS5 MAPK11 JAK1 CHUK RELA TYK2 GAB2 NFKBIA STAT5B PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260410%WP5103%HOMO SAPIENS Progeria associated lipodystrophy TGFB1 FFAR3 SMAD2 PPARG ZMPSTE24 FNTA INS BANF1 ICMT LMNB2 MUCL3 SPRTN WRN SMAD4 LMNA RECQL PARP1 FBN1 KCNJ6 ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260410%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis ARHGEF1 TBXA2R PTGS1 GNA13 ARHA CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260410%WP4191%HOMO SAPIENS Caloric restriction and aging NAMPT MTOR PRKAB2 SIRT1 IGF1 PPARGC1A JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260410%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells EPOR SOCS3 SOCS1 CCND2 PRLR NRAS STAT1 CDK4 STAT3 HRAS MTOR SOCS2 CISH IL6 IL6R FOXM1 CCND3 GHR KRAS EPO AKT3 RPTOR GH1 MLST8 IFNGR1 PRL IFNGR2 IFNG AKT1S1 STAT5B ARYLAMINE METABOLISM%WIKIPATHWAYS_20260410%WP694%HOMO SAPIENS Arylamine metabolism SULT1A1 NAT2 UGT1A9 SULT1A2 UGT1A4 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260410%WP185%HOMO SAPIENS Integrin mediated cell adhesion CRK MAP2K5 PIK3R2 ROCK1 TLN1 RAP1A CDC42 FYN VASP CAV3 MAPK4 ITGB5 ITGB1 SHC3 CAPN3 ITGB4 ITGB8 ITGB7 ITGB6 HEL-S-28 ITGA7 DOCK1 PDPK1 ITGAM ITGAV ZYX AKT3 ITGA4 ITGA2 PAK1 RHO ITGAE MYPN ITGA1 CAPN9 CAPN6 ITGAX CAPN7 CAPN5 TNS1 GIT2 CAPN11 CAPN10 ITGA6 VAV3 VAV2 ROCK2 CAPNS1 MAPK7 RAC3 PAK6 ARAF MAPK1 PAK4 CSK HRAS ARHGEF7 MAP2K6 MAP2K3 MAP2K1 MAP2K2 BRAF MAPK6 MAPK12 MAPK10 GRB2 SOS1 RAF1 ITGB3 ITGA2B RAC1 SRC PXN MYLK2 SELENOP HEL114 CAV2 RAPGEF1 ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260410%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease EGFR BDNF RAF1 NTRK2 HTT RPS6KA5 MAPK1 CASP3 HRAS MAPK3 EGF MAP2K1 MAP2K2 CREB1 TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260410%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition CDH6 SNAI1 SMAD2 CDH2 ID1 AKT3 MAPK1 HEL113 SMAD4 MAPK3 SNAI2 RUNX2 TNC CDH16 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260410%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer MAPKAP1 PTEN PIK3R1 EIF4EBP1 ARAF NRAS MAPK1 TSC1 HRAS MTOR MAPK3 RPS6KB1 MAP2K1 MAP2K2 INPP4B BRAF PIK3CA GRB2 KRAS SOS1 DEPTOR RAF1 SOS2 PARP2 TSC2 IRS1 AKT3 RPTOR MLST8 AKT1S1 RICTOR PARP1 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260410%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260410%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias MMP9 STAT1 RUNX3 ALPL HMGCS1 FGFR1 TGFB1 BMP7 IGF1R IGF2 IGF1 CDKN1C PTCH1 FRZB IHH CHST11 GLI3 THRA PTH1R PTHLH COL2A1 ACAN FGF18 FGFR3 ENPP1 KIF3A RUNX2 FGF2 CALM1 ADAMTS4 GHR PTH ADAMTS5 COL10A1 TIMP3 PLAT SOX6 NKX3-2 SOX5 SPP1 DDR2 CAB39 CST5 SCIN BMP6 GH1 MGP SOX9 MEF2C STAT5B VEGFA BMPR1A TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260410%WP2113%HOMO SAPIENS Type III interferon signaling STAT2 IRF9 JAK1 IFNL2 IL10RB IFNLR1 TYK2 IFNL3 IF1IB1 STAT1 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260410%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis GATA3 EGR2 PPARG CEBPA KLF15 KLF2 CEBPB KLF5 DDIT3 GATA2 CEBPG CEBPD OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260410%WP5574%HOMO SAPIENS Oligodendrocyte development OPALIN ZBTB33 HES5 TMEM98 CNTN1 NFATC2 CHD8 SOX2 ID2 SOX11 OLIG1 OLIG2 MBP BMP1 NKX6-1 SMAD1 FGF2 NKX2-2 SOX10 EGR2 RELN SOX6 SOX5 PDGFRA SHH ID4 PRKCA SOX8 NFIA SOX9 TCF7L2 ZEB2 WNT10A CSPG4 MYRF ASCL1 PTN ZNF24 DUSP15 ZNF488 LGI1 NKX2-6 MYT1 BMP4 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260410%WP2001%HOMO SAPIENS miR targeted genes in adipocytes LPL SRSF10 TMED10 CYP1B1 TMEM43 ELOVL5 SRSF9 CAP1 PHC2 IGF2R FADS1 CEBPB PICALM TGFBR2 G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260410%WP45%HOMO SAPIENS G1 to S cell cycle control CDK6 MYC CCNH CDKN2B CDK7 CDC2 PCNA CDK4 CDKN2C ORC6 ORC3 ORC2 ATF6B CDKN2D ORC1L CCND3 RB1 TFDP1 TFDP2 E2F2 E2F3 CCND1 CDKN1C MCM7 CDKN1A CCNG2 PRIM2 GADD45A MNAT1 POLA2 CCND2 RPA3 MCM3 RPA1 MCM5 MCM6 CDKN2A CCNE1 CDK2 MDM2 MCM2 PRIM1 CCNE2 CDC45 ATM CDKN1B CREB3L3 CREB3L4 POLE CREB3 CCNB1 POLE2 CREB1 MYT1 WEE1 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5406%HOMO SAPIENS 13q12 12 copy number variation MIPEP LINGO1 C1QTNF9 ATXN1 SGCD CDC42 SGCB SACS SGCG TNFRSF19 C1QTNF9B ARHA SPATA13 SGCA DMD SSPN TRAF1 TRAF5 SNTB1 RTN4 MAPK8 RTN4R DAG1 SNTA1 TRAF2 RAC1 MAPK9 TRAF3 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260410%WP3945%HOMO SAPIENS TYROBP causal network in microglia NCKAP1L IL13RA1 PLEK CXCL16 RUNX3 SH2B3 HEL-S-66 RPS6KA1 PYCARD MAF ITGAM NCF2 ITGAX TYROBP C1QC TGFBR1 HCLS1 GAL3ST4 DPYD TNFRSF1B CD84 NRROS FKBP15 SLC7A7 LOXL3 TCIRG1 PPP1R18 ZFP36L2 CD37 RNASE6 LGALS9C NPC2 IL10RA APBB1IP BIN2 ELF4 SFT2D2 TMEM106A RBM47 IGSF6 KCNE3 SAMSN1 ADAP2 HLX CYTL1 LHFPL2 HIMAP2 GAPT LYL1 SPP1 IL18 CREB3L2 GPX1 RGS1 HEL-S-62p INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260410%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR HDAC3 NFATC3 NFATC2 EP300 HDAC7 HDAC5 NELFCD CDK9 PPP3CC SP1 NELFB NELFA PPP3CA PPP3R1 NFKB1 CREBBP NFATC1 HDAC2 HDAC1 SUPT4H1 HEXIM1 SUPT5H HDAC8 RELA HDAC9 PPP3R2 NFKBIA NFATC4 N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP5153%HOMO SAPIENS N glycan biosynthesis DDOST RPN1 FUT8 TUSC3 ALG1 MGAT1 MPDU1 DPM2 B4GALT2 B4GALT1 RFT1 DPAGT1 ALG8 ALG9 ALG6 SRD5A3 ALG2 ALG14 ALG13 ALG3 DOLK ALG12 ALG11 DPM1 GMPPB DPM3 MAN1A2 MGAT2 MAN1A1 GCS1 ST6GAL1 ST6GAL2 ALG5 ALG10 MAN1B1 ALG10B GANAB MAN2A2 MAN2A1 MGAT5 MGAT5B MGAT3 MGAT4C MGAT4D MGAT4A DOLPP1 MGAT4B STT3A RPN2 STT3B LAC PHE PATHWAY%WIKIPATHWAYS_20260410%WP5239%HOMO SAPIENS Lac Phe pathway CNDP2 ABCC5 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260410%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer RPH3A RAB27A SYTL1 RAB27B MYRIP SYTL5 UNC13D TBC1D10A SYTL2 MLPH EXPH5 MADD GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260410%WP455%HOMO SAPIENS GPCRs class A rhodopsin like BRS3 MC4R CCKAR GHSR LHCGR TBXA2R NPY5R AVPR1B NPY1R HRH3 PTGIR OPRM1 AVPR1A SSTR3 SSTR4 FPRL2 TRHR SSTR5 OPRD1 NPY4R OPN1SW FPR1 OPN1MW MC2R GALR3 OPN1LW GALR2 GALR1 NTSR2 RHO NMBR MC1R MC5R CMKLR1 CCKBR MGRA OR1G1 F2RL2 GRPR OR1F1 OR2H1 GPR15 OR3A3 OR10A5 OR3A1 PTGFR OR1E1 C5AR2 GPR83 CXCR4 OR2B6 NTSR1 P2RY13 GPR17 P2RY11 OR2F1 OR2A4 GPR18 OPN4 OPN3 FFAR2 MC3R GPR68 NPFFR1 CNR1 MTNR1A P2RY6 P2RY4 P2RY2 P2RY1 P2RY10 P2RY14 ADORA2A ADRA1D GPER ADRA1B ADRA1A DRD2 DRD3 DRD4 CHRM2 NPFFR2 RRH GPR174 GPR173 GPR171 CMKLR2 GPR37L1 OR1I1 NPBWR2 OR6B1 OR2J3 OR2J2 OR2J1 RGL4 OR6A2 OR7C2 OR7C1 GPR19 IL8RB OR10J1 GPR27 GPR25 PTGDR2 GPR22 FFAR1 CCR10 GPR39 OR5F1 CCR1 GPR37 XCR1 GPR34 GPR32 CCR5 GPR31 OR5V1 OR3A2 OR10H1 OR10H3 GPR45 OR10H2 GPR42 HTR2A MAS1L OR2AG1 CHML CXCR1 GPR52 GPR50 GPR4 SSTR2 GPR3 GPR6 F2RL1 CCR8 OR1C1 CCR7 GPR65 CCR6 GPR63 CCR4 CCRL2 CCR3 OR2D2 CCR2 GPR75 OR2T1 OR1A2 OR1A1 OR2C1 5HT1A SUCNR1 CX3CR1 OR5I1 AGTR2 GPR87 CXCR5 MCHR1 OR2S2 HCAR3 OR1Q1 HCAR1 OR2B3 OR2B2 NMUR2 NMUR1 OR7A10 OR14J1 CXCR3 MLNR PRLHR OR8D2 OR7A17 OR7A5 OR10A4 OR1E2 CNR2 OR8B8 OR2W1 OR12D3 OR1D5 OR1D2 OR2F2 ACKR4 ACKR2 ADRB2 OR11A1 KPG_010 AGTR1 AVPR2 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B ADRB1 HRH1 HRH2 DRD5 HTR1E F2R HTR1F HTR1D OPRK1 HTR1B ADRA2C HTR5A ADRA2B ADRA2A ADRB3 ADORA2B FFAR3 OXTR NPY2R GPR85 DRD1 PTGDR EDNRA FSHR EDNRB HCRTR2 HCRTR1 MTNR1B LPAR4 PTGER4 PTGER1 PTGER2 ACKR3 PTGER3 HTR4 HTR6 HTR7 F2RL3 FPR2 GPR161 BDKRB2 BDKRB1 LTB4R KPG_011 C3AR1 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260410%WP5366%HOMO SAPIENS NF1 copy number variation syndrome H3C15 MCL1 JARID2 H4C9 HIST1H4L MAVS ARF6 PCNA RIGI ARHA EXOC7 NGFR SDC2 OMG RBBP7 RAD51 EED RTN4R NGF IFNB1 TUBB SYN1 EXOC8 ROCK2 EGFR BCL2 LIMK1 EXOC4 EXOC3 EXOC6 NF1 EXOC5 MAPK1 ATR EXOC2 SUZ12 RAD9A EXOC1 MAPK3 MAP3K2 EGF CCNE1 HOXA1 CRY1 MAP3K1 USP1 WDR48 PER1 HOXA9 CCNE2 EVL ADAP2 INPP5A E2F6 RAB11FIP4 SOS1 TEFM RAF1 UTP6 ATAD5 COPRS EVI2A SUPT5H CRLF3 POLRMT EVI2B EIF3A EZH1 METAP2 RFC3 RFC4 RAB11A CCNA2 RFC2 H3C8 HEL-S-15 MYT1 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260410%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging NAMPT FOXO3A SIRT1 PPARG HIF1A SIRT3 ROS1 FOXO1 PARP1 TFAM NFKB1 CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260410%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction ACVRL1 EPOR IL18RAP IL18R1 TNLG5A TNFRSF10B TNFRSF4 TNFRSF18 NGFR TNLG2B BMP8B TNFRSF14 IL10 CXCL2 BMP4 LTB TNLG7A CXCL8 TNFRSF25 IL9 IL9R TNFRSF10C IF2B1 IL23R IL25 IL27 IL34 IL6 IL-21 IL27RA IL21R TNFSF10 IL17F IL17A CSF3 CSF2 IL17D IL17C CSF1 IL17B EPO IL18 GDF3 CSF1R CXCR4 NODAL BMP5 ACVR1B TPO CCL4L2 CXCL17 IF2D IF2G IL36A IL36B IL36RN TSLP IL36G IFNW1 IL1F10 IL3 CXCL12 CXCL6 IL24 IL5 IF1IB1 PF4V1 IL19 CD40LG XCL2 IFNK CCL14 CCL13 IFNL2 CCL18 IFNL3 IL33 CCL23 IL31 IL37 BMP7 CXCL1 LEP CXCL5 LTBR CNTF IL1R2 NGF IFNB1 IFNLR1 BMP10 LIF CNTFR ANP32B CCL5 PRLR TNFRSF1B CCL4 LTA CCL2 TNFRSF19 BMP3 IL10RB IL10RA IL1RL2 GDF10 CD40 IL6ST GDF11 CXCL13 CXCL14 CXCL16 TNFRSF10A IL8RB CCR10 CCR1 XCR1 PPBP CCR5 CXCL11 CXCR1 CXCL9 CXCL3 CX3CL1 CCR8 CCR7 CCR6 IL17RC CCR4 IL17RA CCR3 CCR2 XCL1 CX3CR1 CCL11 CXCR5 TNLG7C CCL1 CXCR6 BMPR2 CCL7 gdf7 CCL3 CCL19 CCL15 CCL25 CCL24 CCL22 CCL21 IL11RA GDF15 CCL20 CCL28 ACKR4 CCL27 LEPR PF4 CCL26 GHR TNFSF11 TNFRSF11B IL20RA BMP6 IL20RB GH1 TNFSF14 CCL8 GDF1 IFNGR1 GDF6 IFNGR2 IL22RA1 CD27 IFNAR2 TNFRSF12A IL17RB RELT CLCF1 TNLG8A INHA IL12RB1 TWEAK MPL TNFRSF8 IL13RA2 EDAR TNFRSF17 ACVR1 CSF3R IFNAR1 TNFRSF9 IL5RA INHBC INHBE IL13RA1 INHBA TNLG1B TNFRSF21 ACVR1C INHBB ACVR2B ACVR2A IL1RN IL3RA TGFB1 IL1R1 IL2RG TNF IL2RA BMP15 IL2RB GDF9 IL11 TNFRSF11A IL15RA IL23A TGFBR1 TGFBR2 IL1A TNFSF6 TACI TNFRSF13C FAS IFNA2 IL15 IL13 ACKR3 GHB2 IL6R TNFRSF1A GDF8 CSF2RB CSF2RA AMHR2 IL2 IL4 IL7 IL7R PRL AMH IFNG GDF5 BMPR1A IL1RL1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260410%WP4249%HOMO SAPIENS Hedgehog signaling SMURF1 EVC2 BCL2 CSNK1A1L SPOP CCND2 CSNK1G3 SMURF2 FBXL17 SPOPL CSNK1G2 BOC CSNK1G1 KIF3A PRKACG GAS1 CSNK1E DHH EVC SHH CCND1 SMO ARRB2 SUFU GPR161 PTCH1 HHIP ADRBK1 PTCH2 IHH CSNK1D KIF7 GLI3 CSNK1A1 CDON HUNGER AND SATIETY%WIKIPATHWAYS_20260410%WP5445%HOMO SAPIENS Hunger and satiety LEP NPY GCG MC4R PYY AgRP GHRL POMC VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260410%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling ADAM10 BRD4 GLUD1 PNP KDR PLCG1 VPS39 OCRL INPP4B EPHA2 PIK3CA MYH9 TBCA TEAD4 CNP ARF4 PRKD2 ANXA1 PRKD1 PPP2CA hEMMPRIN BMP2 ATF2 HBEGF CXCL8 SH3BGRL3 HDAC7 PTGS2 FOXO1 TNFRSF25 HDAC5 CTNNA1 MAP3K5 TNFRSF10C PLAUR ERN1 ACOT9 PPP3CA MDM2 CREBBP CTGF AMOT MMRN2 ATF4 ITGB3 DPM1 FGA GPX1 GJA1 SIAH2 GRB10 PRKCI MEF2C HGS SH2D2A GATA2 IQGAP1 HEL-S-15 TXN SYNJ1 RAB5A NFATC2 AP2A1 SELE XB DUSP5 NCK1 EPN1 HEL-S-78p ARF6 HEL-S-2a ALB PABPC1 AP2S1 ITCH EIF4G1 ITGB1 FLT1 ACACB ACACA TFAM NRP2 PRKG1 NFATC1 HMGB1 NUMB NCF2 MAPKAPK5 ITGAV HEL-S-133P CACNA2D1 CYBB TXNIP FRS2 BMP10 AKT1S1 SARS1 NFKBIA FXR2 PRKAA2 MOV10 NOX4 CYP2C8 CCL2 CAMKK2 DNAJB9 ADAM9 HLX PRKCB HEL164 RPL5 PRKCE PRKCA SRC PXN HEL-S-99n RELA F3 RPL10A MAPK9 PTK2B RICTOR EGR1 HEL114 RPL7 VEGFA PLA2G5 RPL18A HBD RPLP2 HEL2 NCL PTMAP7 RPS11 SDCBP PRKAA1 FOXO3A QK3 P4HA2 RPL13A SHC2 ITGB5 RPL27 RPL26 CYR61 AAG1 PDPK1 FLNB EPHB2 LDB2 ABCF2 TMSB4X CCRL2 FBXW11 HDAC9 VAV2 PFN1 TUBA1C ROCK2 ATP6V1E1 TUBB8 DECR1 TRPC1 MAPK1 CSK HRAS MAP2K6 MAPK3 MAP2K3 MAP2K4 JUN MAP2K1 TMOD1 MAP2K2 TPM3 ADRB2 S1PR1 MAPK14 EIF2A MAPK12 PLCB3 GRB2 RAF1 MYL2 SLC8A1 ELOC RPS6KA5 MLST8 RAC1 RAB11A HEL-S-87p RPS6 TPP1 HEL-S-68p HEL-S-162eP NCF1 PSMD11 CREB1 RAPGEF1 ENG MMP2 CRK MAPKAP1 MMP14 EZR PIK3R2 PIK3R1 ROCK1 SHB FOXO4 CBL CSRP2 PRKCZ RAP1A BMX CDC42 tal-1 PSMD4 FYN EIF4E TRAF3IP2 STAT1 ARHA LUC7L UBAP2L STAT3 CHAC1 PTPN11 IER5 MTOR TMEM170A SND1 ERG RPS6KB1 KATNAL2 FUT1 EWSR1 PTPN6 BIN1 ATP6V0D1 SET GIGYF2 DHX36 MYO6 MICAL2 PRRC2C BIRC5 LARP7 SRPK1 HEL-S-128m EPRS1 CALU FHOD1 HYOU1 HDAC1 DHX29 FARSB FAF1 KCNC3 GSK3B CCDC124 SRP54 EEA1 ACTG1 CCND1 CLIC1 CGNL1 ARRB2 MAPK8 SLC2A14 PAK1 SSR4 GPC1 FLII SSR3 FJX1 NAPA KANK1 CRIP2 SLC7A1 FADD APOLD1 FHL2 CLTC LMAN1 FGD5 PRKRA HEL-S-102 COPG1 CTNND1 PLOD3 TMSB10 TMOD3 SEMA6D DOK1 ARMCX1 TRPC3 RAB37 ZNF555 MAPKAPK2 DSC1 LRRC59 BCL2 FAS HTRA1 ZC3H15 CYCS CCT7 HEL-S-94n KL SDF2L1 LIMK1 HEL-S-84 AFDN TFCP2 SPIRE1 TAOK2 GRSF1 C15orf39 NRARP RND1 RAB4A CAPZB LRRFIP2 ACKR3 ADAMTS9 MMP10 ARHGEF15 SHROOM2 IGFBP7 EIF3S3 DKK1 SLC25A11 PPM1G BCL2L1 DNAJB4 FAM120A NFKB1 WASF1 SLC25A25 PDE4DIP CDC42BPB ELOA NR4A3 PTPN1 FMNL3 PTPN9 EIF3F EIF3D CTNNB1 MYO1C HEL107 DLL4 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260410%WP4918%HOMO SAPIENS Cellular proteostasis VBP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260410%WP4220%HOMO SAPIENS Neurotransmitter disorders TPH2 PNMT TPH1 DBH DDC TH MAOA SLC18A2 SLC6A3 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260410%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis PCSK1 GCG GLP1R INS PCSK2 WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260410%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia LRP6 MYC TCF3 GSK3B WIF1 JUP PML CCND1 RARA NR1C2 PYGO1 BCL9 WNT1 SALL4 CTNNB1 ZBTB16 AXIN2 LEF1 CSNK1A1 DKK1 FLT3 RUNX1T1 LRP5 APC VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260410%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders ALPI HEL-S-302 ALPL HEL-S-1a PIGV ALDH7A1 PLPBP EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260410%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX PLA2G5 PLA2G6 EHHADH PTGS2 PTGIS TBXA2R PTGS1 PTGDR2 AKR1B1 PTGIR ACOX1 PTGES PRXL2B PPARG HEL-S-298 HPGD CYP4F2 CYP4A22 NR1C2 PTGR1 PTGFR CYP4F12 PTGDR PLA2G4B CYP4A11 ACOX3 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260410%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation IGF1R FOXM1 MYC KRAS IGF1 PDGFA INS FOXO1 INSR RASSF1 AKT3 CDK4 MAPK1 PDX1 RAB43 MAPK3 FLT1 TGFBR1 CDK2 BRAF CRTC2 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260410%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder PRKAA2 GRIN3A PTEN BDNF PIK3R2 PIK3R1 EIF4EBP1 CACNA1C SYNGAP1 NRAS NF1 NTRK2 HOMER1 PRKAA1 MAPK1 TSC1 DLG4 HRAS MTOR PRKAB2 MAPK3 RPS6KB1 SHANK3 PRKAB1 RHEB GRIN1 PIK3R3 PIK3CA KRAS GSK3B UBE3A TSC2 PRKAG1 AKT3 PIK3CD PRKAG2 CAMK4 RPTOR ARC PRKAG3 GRIN2B GRIN3B NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260410%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells AOX1 UGT1A9 CYP2B6 UGT1A4 CYP2A6 APOPTOSIS%WIKIPATHWAYS_20260410%WP254%HOMO SAPIENS Apoptosis BBC3 MCL1 MYC PIK3R1 TNFRSF21 BAD NFKBIE BCL2L11 IRF1 TNFRSF10B TRAF1 BIRC5 TP63 IGF1R BIRC2 BIRC3 IRF6 IGF2 TP73 IGF1 TNF TRADD BCL2L2 CASP9 NFKBIB CASP8 CASP6 TRAF2 CASP10 CASP3 CHUK FADD DFFB NFKBIA DFFA IRF3 APAF1 TRAF3 IRF7 TNFSF6 HRK BCL2 FAS CYCS CASP4 TNFRSF25 IKBKB TNFRSF1B LTA IKBKG BAK1 CDKN2A MAP2K4 BAX JUN MAP3K1 MDM2 BCL2L1 NFKB1 TNFRSF1A TNFSF10 CASP2 MAPK10 BOK RIPK1 PMAIP1 IRF4 IRF2 BNIP3L HELLS SCAF11 RELA DIABLO CRADD PRF1 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260410%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure MAPK10 HSD3B2 CASP3 STAR BAX PARP2 HEL-S-2a CYP11A1 FOLATE METABOLISM%WIKIPATHWAYS_20260410%WP176%HOMO SAPIENS Folate metabolism PLG CBS INS HEL-S-78p INSR CTH HEL-S-44 ALB SAA1 SAA2 NFKB2 MTHFD2 MTRR TNF MAT1A SHMT1 SCARB1 MPO APOB DHFR LDLR ABCA1 CCL2 HEL-S-51e FLAD1 IL6 CRP NFKB1 SERPINA3 CSF1 HBB MTR PLAT IL2 IL4 FGA GPX2 GPX1 GPX4 GPX3 GPX6 HBA2 IL1B F2 RELA IZUMO1R F7 IFNG SLC46A1 FOLR3 FOLR2 MTHFS MTHFD1 SAA4 FOLR1 SLC19A1 NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260410%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis RIPK1 FTL FADD TICAM1 RIPK3 TNF TRADD PARP1 MAPK8 TNFRSF1A CASP8 SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260410%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway SCARB1 TMPRSS2 ACE2 ACAT1 NRP1 SLC6A19 TMPRSS4 FURIN TLR7 CTSL MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260410%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders ACADL EHHADH ACSL3 ACSL1 HADHB CPT2 SLC25A20 CPT1A ACADM PECR SLC22A5 FACL4 ACADVL ACSF2 ACADS FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260410%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor MAPK10 TGFB1 STAT3 ACTA2 COL1A1 MAPK9 ENPP2 LPA MAPK8 RHO CTGF PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260410%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway HSPA4 HEL-S-91n UBE2G1 CASK PSMD13 UBE2G2 SNCAIP PSMD9 PSMD6 PSMD7 FBXW7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 SIAH1 HEL-S-72p PSMC6 PSMC4 PSMC1 GPR37 CASP8 UBE2J2 UBE2J1 TUBA1C TUBB PARK2 TUBB2A TUBA1A TUBA3E TUBB4B HSPA2 TUBB4A TUBB8 TUBB6 TUBB1 TUBA1B TUBA4A TUBA2 TUBA8 TUBAL3 CCNE1 UBE2L6 SNCA HEL-S-89n SIAH2 SEPT5 PSMD10 RNF19A PSMD12 STUB1 HEL-S-103 PSMD11 TUBA4B HSPA14 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260410%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation PPP1CC DCAF1 MYC CUL4A LIN28B RBX1 INSR NF2 FGFR4 PRKACG KDR PRKAR1B PRKAR1A ITGB5 FGFR1 ITGB1 DDB1 FLT1 ITGB4 ITGB8 FLT3 ITGB7 ITGB6 EPHA2 FLT4 PLCB4 ITGA7 IGF1R WWTR1 FOXM1 NGFR ITGAM CCND1 ITGAV ITGA4 ITGA2 PAK1 ITGAE ITGA1 ITGAX TEAD2 LATS1 LATS2 TEAD3 CDH10 TEAD4 CDH11 CDH12 ITGA6 CDH15 CDH16 CDH17 CDH18 CDH19 KIT MET EGFR VGLL4 FGFR3 CD44 YAP1 CTNNA1 PAK6 NRAS NTRK1 NTRK2 PAK4 HRAS CDH9 PPP1R14A CDH8 CTGF AMOT HEL-S-80p CDH6 CDH4 KRAS ITGB3 CDH2 ITGA2B PDGFRA CTNNB1 AJUBA CSF1R FGFR2 CDH24 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260410%WP4823%HOMO SAPIENS Genes controlling nephrogenesis NCK2 TCF21 NCK1 ROBO2 CD36 KIRREL1 CXCL12 ETV4 FOXD1 NOTCH2 KDR LMX1B LAMB2 ITGB1 SLIT2 PAX2 CD2AP HEL-S-28 NPHS1 EMX2 NPHS2 FGF8 SHH FOXC2 WT1 SIX1 HOXD11 CTNNB1 MAFB HOXA11 LHX1 GLI3 GDNF EYA1 FGFR2 CXCR4 WNT4 TCF2 FOXC1 VEGFA RET GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260410%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways CUL4A CCNH REV1 GTF2H2C_2 FANCM FANCL FANCB MSH6 FANCE MSH2 FANCF CETN2 REV3L POLI RAD51C FAN1 FAAP24 RAD54B CENPX APEX2 GTF2H2 GTF2H3 GTF2H5 CENPS XPC PMS2 MGMT FANCC ERCC1 APEX1 ERCC2 USP1 WDR48 MPG OGG1 PNKP UNG POLE4 POLD3 POLD4 NTHL1 TDG POLD2 POLE TERF2 MUTYH MBD4 RFC3 RFC4 LIG1 RFC1 RFC2 DDB2 SMUG1 NEIL3 NEIL2 POLE2 POLE3 RAP1A CDK7 RBX1 MSH3 PCNA DDB1 HMGB1 CUL4B PRKDC PARP2 RAD51 FANCG WRN XRCC5 POLM POLL NHEJ1 PARP1 MNAT1 RPA3 CHEK1 BRCA2 RPA1 H2AX FEN1 ATR FANCD2 XPA RAD50 BRIP1 MRE11A ATM BRCA1 NBN FANCA PALB2 RAD52 POLK ERCC5 PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260410%WP5088%HOMO SAPIENS Prostaglandin signaling IL1A AHR MMP9 CXCL8 CCL2 CCL3 PTGER4 PTGER2 IL6 KLRD1 IFNA1 NFKB1 CXCL1 TGFB1 IL17F IL17A PTGES CSF1 PYCARD TNF CXCL9 AREG IL1B IL12A IFNG CCR2 NLRP3 VEGFA IRF7 FOXA2 PATHWAY%WIKIPATHWAYS_20260410%WP5066%HOMO SAPIENS FOXA2 pathway ABCC3 FOXA2 ABCC2 APOB INS GSTM2 FOXO1 PPARGC1B IRS1 MLXIPL SLCO1B1 SLC27A5 FOXA1 MTTP FASN ACACA QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260410%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis MAFG FOS KEAP1 JUN PTGS2 NFKBIA IKBKB CYP2A6 NFE2L2 MAFK NFKB1 VEGFA WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260410%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis LRP6 FZD3 WNT3A PROX1 NEUROD1 CCND1 WNT7A WNT3 NEUROG2 FZD1 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260410%WP2249%HOMO SAPIENS Metastatic brain tumor CDK6 MYC PIK3R1 E2F3 CDC42 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260410%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis TLR4 IRAK1 SPI1 RELA NFKB2 APOE TRAF6 INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260410%WP4558%HOMO SAPIENS Interferon mediated signaling IRF9 IFNAR1 PIK3R1 IFNA4 IFNA13 IFNE IFNA7 IFNA14 IFNA6 IFNA16 IFNA2 IFNA17 IFNW1 IFNA8 IFNA10 IF1IB1 STAT1 STAT2 IFNK IFNA21 IFNL2 IL10RB IFNL3 IFNA1 IFNL4 PIK3CA IF1AA9 PRKCA IFNGR1 IFNGR2 JAK1 IFNAR2 IFNB1 IFNG IFNLR1 TYK2 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260410%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 GCKR LPL APOA2 DGAT2 APOA5 FAS LDLR SEL1L GPIHBP1 LMF1 APOA4 GCK MTTP APOC2 LIPC ACSS1 PLTP PDIA2 MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260410%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes MATN1 MATN3 COL9A1 COL9A3 COL9A2 COMP PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260410%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection TUBB TLR4 TUBB2A ROCK2 TUBA1A WAS TUBA3E YWHAQ EZR ROCK1 NCK2 TUBB4B NCK1 TUBB4A TUBB8 TUBB6 TUBB1 NCL CDC42 TUBA1B TUBA4A FYN ARHA TUBA2 TUBA8 TUBAL3 ITGB1 ARPC4 ARPC5 HEL-68 KRT18 ARPC2 ARPC3 LY96 ARHGEF2 ARPC1B ACTG1 CD14 PRKCA CTNNB1 WASL PS1TP5BP1 YWHAZ CLDN1 HCLS1 TUBA1C TLR5 CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260410%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin ADRB1 ANKRD23 FHL1 PRKACG MAPK1 PRKAR1A TTN GUCY1B1 MAP2K1 MDM2 MAP2K2 ADRB2 RAF1 CSRP3 ANKRD2 TCAP HEL-S-101 C22orf13 NBR1 TRIM63 TRIM55 MYPN PRKCA ANKRD1 NUP62 FHL2 CAMK2A HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260410%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260410%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling CSF3R IFNAR1 IL5RA MAPKAP1 DUSP2 SOCS3 F2R MAPK4 STAT3 MTOR PTPRC CTF1 IL3RA IL2RG MAPK8 IL2RA IL2RB PTPRT SETD7 MAPK15 AKT1S1 IFNLR1 IL15RA MAPK13 AGTR2 EGFR CNTFR MAPK7 IL9R MAPK1 F2RL2 TRIM28 MAPK3 IL10RB IL27RA IL10RA IL11RA IL21R F2RL3 IL6R CREBBP MAPK14 MAPK6 MAPK12 MAPK10 CSF2RB CSF2RA GHR DEPTOR AGTR1 PDGFRA JAK3 IL7R MAPK11 PRKCB RPTOR IL20RA IL20RB OSMR MLST8 IFNGR1 IL6ST IFNGR2 SRC JAK1 IL22RA1 IFNAR2 MAPK9 TYK2 RICTOR MPL PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260410%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 RIPK1 BIRC3 CYCS TNF TRADD CASP9 CASP8 TRAF2 CASP3 FADD BAX RIPK3 TNFRSF1A INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260410%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 JARID2 EZH2 RBBP4 SETX RBBP7 EED AEBP2 EZH1 SUZ12 MORC3 ELL BCLAF1 STK38 TRIM35 THRAP3 LUPUS THERAPIES%WIKIPATHWAYS_20260410%WP5560%HOMO SAPIENS Lupus therapies TNLG7A CD22 C4A CD40LG C2 IL25 IL6 C4B_2 IL6R IL17F IL17A IL17D CD40 CD80 IL17C C1QB IL17B C1QA IL12B IL12A C1QC IFNG MS4A1 HEL-S-62p IL23A CD19 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260410%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence EPHX2 CYP2E1 PTGES GPR32 HPGD GSTM4 CYP2C9 ALOX5 PTGS2 CYP2C8 ALOX15 ALOX15B FADS2 ELOVL5 ALOX12 ELOVL2 FPR2 LTC4S FADS1 PTGIS HEL-S-22 PTGS1 CYP3A4 MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260410%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy MAP2K5 PIK3R2 ROCK1 PIK3R1 CDK7 ARHA MAPK4 STAT3 MTOR CTF1 CISH PIK3R3 PRKG1 PIK3CA TGFB1 IGF1R MAP3K14 PLCB2 PDPK1 GSK3B IGF1 TNF MAPK8 IKBKE CHUK WNT3A EIF2B5 HDAC9 MAP3K7IP1 LIF NPPB NFATC4 NPPA ROCK2 PLA2G2A HDAC7 MAPK7 HDAC5 CDK9 IKBKB IKBKG EDN1 MAPK1 MAP2K6 MAPK3 EGF MAP2K3 MAP2K4 PPP3CA MAP2K1 FGF2 MAP2K2 NFKB1 MAPK14 MYLK LRP5 LRP6 CALM1 RAF1 MYEF2 GATA4 DVL1 NRG1 PIK3CD PRKCB FZD1 CTNNB1 IL6ST RAC1 FZD2 FGFR2 CAMK2D MYLK3 PROLACTIN SIGNALING%WIKIPATHWAYS_20260410%WP2037%HOMO SAPIENS Prolactin signaling MYC PIK3R2 PIK3R1 CBL SOCS3 SOCS1 EIF4EBP1 FYN STAT1 STAT3 PTPN11 MTOR SOCS2 RPS6KB1 CISH PTPN6 ITGB1 PPIB PIK3CA GSK3B HEL-S-130P FLNA MAPK8 PAK1 NFKBIB CASP3 YWHAZ SIRPA HEL-S-69p NEK3 NFKBIA VAV2 ERBB2 TEC PRLR YWHAG MAPK1 FOS HRAS MAPK3 JUN MAP2K1 MAP2K2 NFKB1 MAPK14 PTPN1 GRB2 SOS1 RAF1 IRS1 RPS6KA2 PRL RAC1 SRC JAK1 PXN RELA RPS6 AGAP2 MAPK9 GAB2 VAV1 STAT5B ZAP70 CAMKK2 PATHWAY%WIKIPATHWAYS_20260410%WP4874%HOMO SAPIENS CAMKK2 pathway CHRM3 NFATC2 EPOR IFI44L KLF1 NLRP1 KDR MTOR GCK HK2 RPS6KB1 DGIC FASN ULK1 ACACA STIM1 CRTC2 SLCO3A1 MAF AQP1 C1QTNF12 TNF CXCL11 CCND1 PAK1 SLC38A5 MS4A3 HFE PARP1 IFGGE HMBS CPOX OASL TSPAN8 ERMAP GALNT9 MAMDC2 MID1 CAMK1 ERAF SPINT1 DKFZp762B153 EP300 SFI1 SQSTM1 S100A8 KEAP1 ATP10D TSPAN33 RHD ENHO CCL5 ABCA1 CYB5R3 MAP1LC3A HMOX1 SLC25A21 WFS1 MX2 SPIRE1 IL15 CAMKK2 LR8 TRPV4 TSC1 MAPK1 RHAG FAM20C FIS1 SIRT1 ARHGEF7 SLC2A4 MAPK3 CCNE1 NFE2L2 ASNS CALM1 WDR35 RAF1 SMC1A TBXT CAMK4 RPTOR PFKFB2 RAC1 VCAM1 SELL HIF1A RELA RPS6 ATP1B2 CREB1 PCK2 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260410%WP247%HOMO SAPIENS Small ligand GPCRs S1PR2 CNR1 MTNR1A S1PR3 PTGFR GPR50 PTGER4 S1PR4 PTGDR PTGER1 PTGER2 PTGER3 CNR2 MTNR1B TBXA2R LPAR1 S1PR1 PTGIR MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260410%WP5236%HOMO SAPIENS Markers of kidney cell lineage EGLN2 NR2A1 PECAM1 TCF21 NOTCH2 KDR SMAD1 DCN PAX2 BMP7 NPHS1 NPHS2 DKFZp781O1323 HNF1A GDNF BMP4 KIT NTN1 FOXD1 TLX1 CITED1 RSPO3 DACT1 OSR1 AXIN2 KCTD1 TSHZ3 TBX18 FAT4 VSX2 SFRP1 EMX2 ACTA2 NT5E FGF7 FGF8 EPO PBX1 tmp_locus_29 WT1 REN SIX1 SALL1 RSPO1 LHX1 SIX2 ALDH1A2 NOTCH1 EYA1 WNT4 TCF2 TNC EGLN1 EGLN3 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260410%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 ERBB2 AREG HEL113 MYC EGF TIMP1 CCND1 FOSL1 PGR REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260410%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds TNKS DKK3 GSK3B DVL2 WNT1 FZD1 CTNNB1 LEF1 CSNK1A1 AXIN1 FZD7 SFRP4 MBOAT1 FZD8 APC TCF4 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP304%HOMO SAPIENS Kit receptor signaling DOK1 CRK TEC KIT PIK3R2 PIK3R1 EP300 CBL SOCS1 BAD RPS6KA3 FYN KITLG INPP5D STAT1 MAPK1 STAT3 FOXO3A PTPN11 HRAS PLCG1 MAPK3 RPS6KB1 PTPN6 MAP2K1 MAP2K2 SOCS6 MATK MAPK14 SH2B2 LYN GRB2 RPS6KA1 SOS1 RAF1 GRB7 MAPK8 CRKL PRKCB GRB10 PRKCA SRC RPS6 GAB2 BTK VAV1 STAT5B TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260410%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway H4C9 TAF13 TAF8 MED27 MED23 TBP IL1 SIGNALING%WIKIPATHWAYS_20260410%WP195%HOMO SAPIENS IL1 signaling IL1A MYD88 PIK3R2 MAPKAPK2 ATF2 PIK3R1 SQSTM1 PRKCZ IKBKB IKBKG MAPK1 PTPN11 PLCG1 MAP2K6 MAPK3 MAP3K2 REL MAP2K3 MAP2K4 JUN MAP2K1 MAP3K1 MAP2K2 NFKB1 ECSIT MAPK14 HSPB2-C11orf52 IRAK2 IL1R1 MAP3K14 TAB3 MAPK8 NFKBIB IRAK1 CHUK IL1B RELA IRAK3 HEL-S-71 MAPK9 MAP3K7 IRAK4 PELI1 NFKBIA MAP3K7IP1 TRAF6 UBE2V1 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260410%WP528%HOMO SAPIENS Acetylcholine synthesis ChAT ACHE CHKA PEMT PDHA1 PDHA2 AMINO ACID METABOLISM%WIKIPATHWAYS_20260410%WP3925%HOMO SAPIENS Amino acid metabolism G6PC2 RARS1 CBS PDHX GLUD1 CTH P4HA2 TPH1 FH DBH MDH2 HEL-S-61p SDHA ACLY CS PC OGDH TDO2 SUCLG1 EPRS1 MARS2 ACO2 DLD GOT2 PNMT HMGCL FARSB HAL HEL-S-32 GPT2 HEL-S-30 PIG59 ADH1C HEL-S-133P GCLM ADH7 HEL-S-4 ADH5 SRM DDC TH CAD MAOA ARG2 HDC EHHADH BCAT1 HEL-S-26 SMS ACSS1 ALDH7A1 ASNS PDK4 ALDH18A1 LARS2 PPM1L IARS HEL-S-53e PCK1 HEL-S-64p GLS ARG1 ACADM HEL-75 ASS1 OTC PDHA1 FTCD MCCC1 TPO TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260410%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome AHR TDO2 AADAT HAAO GOT2 AFMID KYAT3 KYAT1 IFNA6 IDO2 TNF KYNU KMO IL1B IFNB1 IL6 IFNG DDC IDO1 GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260410%WP100%HOMO SAPIENS Glutathione metabolism GSTM1 GSTM2 GPX2 GCLC GPX1 GPX4 GCLM HEL-S-64p GPX3 GSTT2 HEL-S-26 OPLAH HEL-75 GSTA5 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260410%WP2363%HOMO SAPIENS Gastric cancer network 2 OTUD5 UBE2C SNURF EGFR MYC COL9A1 COL9A3 DGIC CEBPZ CHTF18 TOP2A S100A6 DSCC1 CHTF8 BRIX1 ATAD2 LMNB2 CACYBP FAM91A1 RNF144B UBE2T AHCTF1 CD48 RAD17 CTNNB1 RFC3 RFC4 MTDH LBR TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260410%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners HDAC3 LATS1 TEAD2 LATS2 HDAC1 SKI MERTK TEAD3 TEAD4 SKIL SIN3A NF1 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260410%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome RAB5A NFATC2 PLN SH2B1 RABEP2 INSR KDR RAB4A ATP2A1 SLN TRAF1 CD82 GRB2 IL4 NFATC2IP TUFM TRAF2 ATXN2L SPNS1 CD81 LAT SDCCAG8 PRMT1 CR2 IFITM1 HEL-S-62p MPL VAV2 CD19 NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism NEU2 B3GNT5 FUCA1 FUT5 NAGA FUT2 SIAT4C FUT1 B4GALT4 B4GALT1 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260410%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions LPL YWHAQ FOXO4 MOB1A YAP1 RAP1A FOXO1 ARHA FOXO3A MAPK14 STK38L WWTR1 FOXP3 PRDM1 RAC1 TEAD2 LATS1 LATS2 TEAD3 FOXO6 CCR7 TEAD4 FYB1 KNSTRN RAB13 FERMT3 CD19 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260410%WP2596%HOMO SAPIENS Gastric acid production PGA5 MUC6 GAS CCK CBLIF SCT PGA3 VIP PGC IL6 SIGNALING%WIKIPATHWAYS_20260410%WP364%HOMO SAPIENS IL6 signaling PIK3R2 PIK3R1 SOCS3 BAD NCOA1 STAT1 MAPK1 STAT3 PTPN11 IRF1 MAPK3 RPS6KB1 IL6 MAP2K4 MAP2K1 CRP BCL2L1 MAP2K2 IL6R CREBBP GRB2 HDAC1 PRDM1 NLK SOS1 GSK3B TIMP1 NR2F6 JUNB IL6ST RAC1 JAK1 MAP3K7 TYK2 VAV1 VIP CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260410%WP4504%HOMO SAPIENS Cysteine and methionine catabolism SUOX SQOR CBS MTR MAT1A pcap HEL-S-61p GCLC CTH CDO1 HEL-S-64p ETHE1 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260410%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors HMGCR MVD THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260410%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects RPS6KA6 TTF2 TTF1 NHSL1 DUOXA2 SECISBP2L DEHAL1 BAD SLC26A4 TRH ADRB3 TG MTOR DUOX2 SIRT6 RPS6KB1 MC4R FGFR1 AgRP ITPR2 AQP7 PIK3CA SLCO1C1 PRDM16 TSHB PPARG SLC16A10 GSK3B SLC16A2 PPARGC1A SHH ITGAV ADCY3 CASP9 AKT3 ZNF516 ACTL6B KDM3B UCP1 TSHR FRS2 THRA AKT1S1 NPPB MAPKAPK3 SLC5A5 NPY ATF2 ADCY8 FGF21 FOXO1 POMC PLIN1 MGLL PNPLA2 TSC1 MAPK1 HRAS MAFA RXRA RHEB MAP2K1 TBC1D4 MDM2 MAPK14 GRB2 SOS1 RAF1 ITGB3 TSC2 KDM1A RPTOR PFKFB2 CTNNB1 MLST8 DIO1 SRC CREB3 NOTCH1 RPS6 PAX8 WNT4 NR1A2 TPO COMPLEMENT SYSTEM%WIKIPATHWAYS_20260410%WP2806%HOMO SAPIENS Complement system PLG TXN C1QBP RPS19 SERPING1 SELE MASP1 CD46 CLEC4M ICAM2 VTN HEL-S-78p C4A FCGR3A C1S VSIG4 CFH CD93 ALB HEL-S-92n CFI FCER2 FKBP2 CFP CD59 CFHR2 CFHR4 PTX3 SFTPA1 F10 PROS1 DCN ADM CPN1 ELANE LAMC1 FPR1 GNAI3 ARRB2 ITGA2 SELP CR2 CD19 LAMA5 WAS F13A1 CFD C2 PLAUR CD55 THBS1 LAMB1 CRP GNA15 IBSP CD40 ITGB3 ITGA2B SPP1 FGA PRNP PRKCA C5AR2 SELL FCN1 FCN2 HEL-S-99n F11 SELPLG C6 C4BPA C7 CSNK1A1 SFTPA2 HEL-S-62p C9 KLKB1 C5AR1 C3AR1 MBL2 MASP2 C8A CR1 ONE CARBON METABOLISM%WIKIPATHWAYS_20260410%WP241%HOMO SAPIENS One carbon metabolism MTRR MTR DHFR AHCYL2 MAT1A TCN2 HEL-S-51e FOLH1 MTHFD1L SHMT1 MTFMT GLRX TYMS HEL-S-70p AMT MTHFS HEL-S-61p FTCD MTHFD2 CHDH MTHFD1 DNMT3B PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260410%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins PRKAA2 LARP1 ATG9A DKFZp762B153 ATG3 SQSTM1 APOB ATG12 EIF4B ATG16L1 MTOR VPS39 RPS6KB1 RHEB VPS11 VPS16 VPS18 VPS33A ULK1 CALCOCO2 VAMP8 VPS41 OPTN RAB7A DEPTOR RB1CC1 LAMP2 PPP1R9A LAMTOR1 HEL-S-30 TMEM59 NBR1 RPTOR MLST8 RPS6 AKT1S1 ATG2B ATG5 GABARAPL2 LUPUS PATHOGENESIS%WIKIPATHWAYS_20260410%WP5559%HOMO SAPIENS Lupus pathogenesis TLR4 IL17A TNFRSF13C TNLG7A CD40 BCR CD80 ICOSLG IFNA2 CD40LG ICOS IL6 PDCD1 TLR9 TLR7 EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260410%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance PTEN MYC PIK3R2 PIK3R1 BAD EIF4EBP1 EIF4E PLCG2 KDR STAT3 FOXO3A BCL2L11 MTOR PLCG1 RPS6KB1 SHC4 SHC2 SHC3 PIK3R3 PIK3CA PDGFD PDGFC IGF1R PDPK1 GSK3B IGF1 PDGFA CCND1 AKT3 HGF TGFA ERBB2 MET EGFR FGFR3 BCL2 ERBB3 ARAF NRAS NF1 RRAS NRG2 MAPK1 HRAS MAPK3 EGF IL6 BAX MAP2K1 RPS6KB2 BCL2L1 FGF2 MAP2K2 RRAS2 BRAF IL6R GRB2 KRAS SOS1 RAF1 SOS2 PDGFRA NRG1 PIK3CD PRKCB PRKCA AXL SRC JAK1 RPS6 FGFR2 VEGFA VITAMIN D METABOLISM%WIKIPATHWAYS_20260410%WP1531%HOMO SAPIENS Vitamin D metabolism CYP24A1 CYP2R1 PTH RXRB RXRA DHCR7 CYP27A1 CYP27B1 NR1i1 GC TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260410%WP465%HOMO SAPIENS Tryptophan metabolism AHR ECHS1 AANAT AOX1 STAT1 CYP1A1 IL4I1 TPH2 TPH1 ASMT IDO1 AOC1 ALDH8A1 TDO2 HAAO AADAT AFMID GOT2 DLD ACAT1 KYAT3 KYAT1 IDO2 KYNU INMT ALDH2 KMO GCDH DDC MAOA KALLMANN SYNDROME%WIKIPATHWAYS_20260410%WP5074%HOMO SAPIENS Kallmann syndrome OTX2 SOX10 SEMA3E TMEM98 GRB2 FGF8 NEUROG1 LHB PLXND1 OLIG2 MAPK1 PTPN11 FRS2 GNRH1 PROK2 FGFR1 MYRF ASCL1 MAP2K2 ANOS1 PIK3CA BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260410%WP3927%HOMO SAPIENS BMP signaling in eyelid development EGFR DKFZp781O1323 SHH FOXC2 INHBB SMAD4 MAPK3 NOTCH1 SMAD1 MAPK9 FGFR2 FGF10 JUN TGFA FOXC1 DKK2 MAP3K1 PITX2 SFRP1 BMP4 LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260410%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism ACAD8 IVD ACSF3 DBT DLD ECHS1 ACAT1 MLYCD HSD17B10 ACADSB BCAT1 BCAT2 MCCC2 PCCA MCCC1 PCCB IL19 SIGNALING%WIKIPATHWAYS_20260410%WP5422%HOMO SAPIENS IL19 signaling TGFB1 CCL11 ACTA2 MUC5AC TNF IL4 SOCS1 MAPK8 SOCS5 STAT1 IL20RA IL19 IL20RB STAT3 MAPK1 RAC1 COL1A1 JAK1 MAPK3 CCNB1 CXCR4 NFKB1 MAPK14 TNFRSF1A KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260410%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 SERPING1 KLKB1 CPN1 BDKRB2 BDKRB1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260410%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV SHANK1 RPH3A CAMK2G TJP1 YWHAG SYNGAP1 DLGAP1 HOMER1 MAPK1 MAPK3 GRIN1 CYFIP1 FMR1 DLG2 RYR2 NLGN1 NRXN1 NRXN3 ARC NRXN2 STX1A CAMK2D CAMK2A GRIN2B NLGN3 NLGN2 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260410%WP4931%HOMO SAPIENS Direct reversal repair MGMT ALKBH3 ALKBH2 LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260410%WP4299%HOMO SAPIENS Lamin A processing pathway LMNA ZMPSTE24 ICMT COCAINE METABOLISM%WIKIPATHWAYS_20260410%WP2826%HOMO SAPIENS Cocaine metabolism CES2 CES1 BCHE CYP3A4 NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260410%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling STEAP3 ACE2 CTSL IL18RAP IFIT1 APOL1 ULK1 HEL-S-72p APOH COQ8B RTN4 SELP TP53I3 IFITM1 IL10 CXCL2 LARP1 MX1 CXCL8 PTGS2 IL9 INTS4 IKBKG IF2B1 FOS CD3G CD3E IL6 IL-21 RHEB GGH FGF2 TNFSF10 IL17A HBB DEPTOR TOMM70 IL18 FGA IL1B TPO NLRP3 C1QBP IFI44L HEL-S-78p CXCL12 CXCL6 C1S CFH IL5 CASP5 ALB C1R CFI SAA1 NLRP1 CFP SAA2 ITCH SMAD1 VPS11 VPS16 CEBPB VPS18 IL33 VPS33A VPS41 CXCL1 DDIT4 CXCL5 DKFZp781O1323 HEL-S-130P IFITM3 CCNB2 HEL117 GTSE1 VPS36 WDR74 IFI27 IL1R2 CD226 TBK1 HEL103 TRAF2 BST2 IRAK1 HRG CTSZ SERPINA10 IFNB1 SDF2 IL16 HMFT1766 AKT1S1 IFI6 OS9 SRP19 CARD11 HEL-S-81p IRF3 HP TRAF3 PMPCB TRAF6 CLCC1 NFATC3 GTF2F2 UGCGL2 MYD88 PITRM1 G3BP2 NPTX1 DKFZp762B153 MOV10 MDN1 FAM83A TRO TRIM59 ITIH4 TBKBP1 ITIH3 CCL5 CCL4 ATE1 CCL2 ATP13A3 FAM98A NTRK1 APOC1 CRP APOA2 TLE3 ADAM9 LBP CD14 JUNB HIF1A EGR1 HBD IFIH1 MAVS CDC2 RIGI CXCL13 CXCL16 IL8RB LGALS3BP TF CCR5 SIGMAR1 TRPM2 CXCR1 CXCL9 CXCL3 RRM2 CCR6 CCL11 AHR CD163 CCL1 EIF4A2 RRAS CCL3 APOD CCL15 CCL22 JUN CCL21 CCL20 CCL27 PF4 CCL26 CAMK4 RPTOR CCL8 GP1BA CD8A MLST8 RAC1 JAK1 CCNB1 RPS6 PIAS1 ZAP70 LCK GABARAPL2 IRF9 EIF4EBP1 OAS2 FYN EIF4E STAT1 MTOR NFKB2 PTPN6 CPN1 BIRC5 NRF NEK9 CD8B1 PRG3 CD2 MMP25 IGLL1 TNF SRP54 PARP2 ACTG1 CASP9 MAPK8 CASP8 PS1TP5BP1 CASP3 PRKCQ IL12A TGFBR2 IL1A IL13 HLA-DRB5 HLA-DRA HLA-DRB1 MIB1 IL4 IL7 IFNG C8A ROTENONE METABOLISM%WIKIPATHWAYS_20260410%WP5486%HOMO SAPIENS Rotenone metabolism CYP2C19 CYP3A4 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260410%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260410%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly HIRA H4C9 HIST1H4L CHAF1B SMIM40 RBBP4 CHAF1A H2BC12 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome ADAM10 MYC MCRS1 TFRC SLC40A1 RNF168 FBXW7 NF2 PIK3R3 TGFB1 TF SLC51A SLC51B DYNLRB2 PIGX HEL-S-71 PIGM HFE CEP19 DYNLT3 DYNC2I2 DYNLT1 UBXN7 SMCO1 NCBP1 NRROS NCBP2 FNDC8 MFI2 SIRT1 MYCBP2 FBXO45 ZDHHC19 BRINP1 TM4SF19 JUN CEP350 MAD2L1BP WDR53 ZNF76 RABL2B RNF8 DYNC2H1 H2BC21 HAMP DYNLL2 PXN HIF1A DNCL1 DYNLT2B STAT5B DYNC2LI1 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260410%WP558%HOMO SAPIENS Complement and coagulation cascades PLG SERPING1 MASP1 CD46 F2R HEL-S-78p C1S CFH C1R CFI KNG1 F9 PROC F10 PROS1 F13B C4B_2 VWF C1QB C1QA THBD C1QC CLTC CR2 LMAN1 CFD C2 PLAUR CD55 SERPINA1 CPB2 SERPINC1 TFPI PLAT BDKRB1 SERPINF2 F2 F3 F5 F7 C6 F8 C7 HEL-S-62p CLU C9 KLKB1 C8G C5AR1 C3AR1 MASP2 CR1 SERPIND1 SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260410%WP4814%HOMO SAPIENS Somatic sex determination DMRT1 DHH GATA4 FOXL2 NR5A1 FGF9 WT1 CTNNB1 SOX8 SOX9 SRY RSPO1 AMH WNT4 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260410%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum GPS1 H4C9 CUL4A MNAT1 CCNH HIST1H4L CDK7 GTF2H2C_2 RPA3 RPA1 RBX1 PCNA CETN2 GTF2H2 GTF2H3 DDB1 GTF2H5 XPA SLX4 CUL4B SLX4IP CHD1L BRCA1 POLE4 POLD3 POLD4 HMGN1 H2AC6 RAD18 POLD2 XPC POLE POLK RFC3 RFC4 LIG1 ERCC1 RFC1 ERCC2 RFC2 DDB2 H3F3B PARP1 XAB2 POLE2 UVSSA POLE3 ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260410%WP4298%HOMO SAPIENS Acute viral myocarditis MMP9 PIK3R1 SOCS1 FYN PABPC1 STAT1 CD40LG STAT3 NFKB2 EIF4G1 SGCA HEL-S-28 TGFB1 AAG1 NOD2 HLA-DMA PYCARD CCR5 GSK3B TNF CCND1 CASP9 CASP8 CASP6 PS1TP5BP1 CASP3 IL12B IL12A TICAM1 IL10 CCR3 DFFB DFFA PARP1 TLR5 TLR4 AIF1 BCL2 CYCS SGCD SGCB RAC3 SGCG EDN1 MAPK1 ABL2 MICA CD55 MAPK3 IL6 BAX DMD BCL2L1 CASP2 CAAP1 CD80 CXADR SOS1 CHRAC1 BNIP2 TLR3 IL2 MYH6 DAG1 SRC JAK1 IFNG CXCR4 CREB1 DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260410%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases NPC1 GLB1 LIPA NEU3 GM2A PSAP NEU4 NEU1 GLA SCARB2 NEU2 NPC2 HEXB HEXA KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260410%WP4236%HOMO SAPIENS Krebs cycle disorders LDHB SUCLG2 SUCLG1 FH GPT PDHX MPC1 DHTKD1 HEL-S-133P SUCLA2 PCK2 HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260410%WP186%HOMO SAPIENS Homologous recombination RAD50 MRE11A ATM RAD54B NBN POLD3 POLD4 BRCA2 POLD2 RPA1 RAD51 RAD52 NOTCH SIGNALING%WIKIPATHWAYS_20260410%WP268%HOMO SAPIENS Notch signaling PSEN2 RBPJ HES5 DTX1 APH1B NCOR2 NOTCH2 KCNJ5 NOTCH3 DTX3L MAML3 DTX4 MAML1 CREBBP CTBP2 CTBP1 NUMB HDAC2 HDAC1 JAG2 DVL1 DVL2 DVL3 RBPJL DTX2 DTX3 KAT2B KAT2A PSEN1 MFNG NOTCH1 ADAM17 DLL3 DLL4 LFNG HES1 TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260410%WP619%HOMO SAPIENS Type II interferon signaling IRF9 ISG15 H4C9 MHC2TA SOCS3 IFNA2 SOCS1 EIF2AK2 OAS1 IRF8 STAT1 NOS2 STAT2 PTPN11 IRF1 HLA-B SPI1 IRF4 CXCL9 CYBB IFNGR1 IRF2 GBP1 IFNGR2 JAK1 IL1B IFNB1 IFNG IFI6 IFIT2 TAP1 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260410%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases RBPJ PIK3C2G PIK3C2A PIK3C2B PIK3R3 PIK3R5 PIK3CA SMO PTCH1 IHH GLI3 PRKD1 FGF7B MAPK13 BMP4 BMP2 FGF7A FGF18 FGFR3 BMPR2 MAPK1 MAPK3 FGF5C RUNX2 FGF2 MAPK14 LRP5 MAPK12 LRP6 MAPK10 FGF7 FGF8 JAG2 FZD4 PIK3CD HEY2 HES6 PRKCI WNT9B WNT9A NOTCH1 WNT8A WNT8B PIK3R4 PIK3R2 PIK3R1 PRKCZ NOTCH2 NOTCH3 STAT1 FGFR4 MAPK4 SMAD1 FGF10 FGFR1 SMAD9 DKFZp781O1323 PPARG MYOD1 PRKDC MAPK8 PRKCQ SMAD4 WNT3A WNT2B FZD10 MAPK7 WNT5B WNT16 MAPK6 PRKCH WNT1 MAPK11 FGF9 PRKCB WNT3 PRKCE FZD1 PRKCA CTNNB1 WNT10B SOX9 WNT10A FZD3 HES3 HES2 FZD2 FZD5 FGFR2 MAPK9 WNT4 WNT7B FZD7 FZD9 DLL3 DLL4 WNT7A FZD8 BMPR1A MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260410%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma CRK PIK3R2 PIK3R1 CBL RPL11 RAP1A BAD CDC42 KDR STAT3 PTPN11 PLCG1 ALK PIK3R3 PIK3CA AKT3 MAPK8 PAK1 CDKN1A HGF MET STRN PAK6 ARAF NRAS MAPK1 PAK4 HRAS MAPK3 JUN MAP2K1 MAP2K2 BRAF PRCC ELOA GRB2 KRAS SOS1 RAF1 SOS2 JAK3 PIK3CD CRKL RAC1 SRC INSL3 C8orf34 VEGFA RAPGEF1 IL17 SIGNALING%WIKIPATHWAYS_20260410%WP2112%HOMO SAPIENS IL17 signaling IKBKB IKBKG TRAF3IP2 SP1 MAPK1 STAT3 IL25 MAPK3 CEBPB NFKB1 CEBPD PIK3CA IL17F IL17A MAP3K14 IL17D IL17C IL17B GSK3B NFKBIB JAK1 RELA MAP3K7 IL17RB IL17RC IL17RA TRAF3 TRAF6 MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260410%WP2005%HOMO SAPIENS miR targeted genes in muscle cell CDK6 EZH2 ABCG2 IGF2BP1 SPARC ARID4B PHLDB2 TXN2 CHORDC1 CDK5RAP3 VPS39 ATP6V0E1 TNFRSF10B IFRD1 HEL-S-66 PISD MTHFD2 RAB34 PPIF PPIB ANAPC1 MYO1E TMED10 SLC1A4 ADIPOR2 RTN4 CORO1C MRPL20 RDH10 SNX6 CD164 BRPF3 HMGA1 TBCA IGF2R CDKN1A CLDN1 SFXN1 SLC25A1 ARF4 SNAP23 TNFAIP2 ATP2A2 SLC7A11 MRC2 HYAL3 KIT SPTLC1 YWHAQ TMEM43 TMED3 CCNG1 TMEM109 SH3BGRL3 ACP2 NELFCD CTSC HMOX1 SCYL1 SLC7A6 CDCP1 RFT1 FRG1 TYMS RHEB THBS1 PPP3CA HEL-S-47e EHMT1 PTPA DNAJB1 FGF2 POLR2C USP1 SHOC2 CDIPT SRSF10 CA12 AP3D1 ARHG ARCN1 WDR11 CSF1 POLE4 FMNL2 TDG POLD2 GJA1 PRKCI NOTCH1 ACVR1B BACE1 MCL1 C1QBP PXDN CXCL12 NF2 CAND1 GFPT1 NEDD4 CEBPB ITGB4 LAMC2 CUL4B CPNE8 LAMC1 VEZT TMEM41B PWP1 MTRR RAVER2 CIAO2A SEC62 HEL-S-30 ITGA2 MBNL1 SLC38A1 HEL-S-303 TRAM1 CBFB CACNA2D1 FNDC3B GRIA2 CSNK1D FNDC3A CARHSP1 WDR82 HACD3 SLC38A5 UBE2J1 COMMD9 GRPEL2 ATP6V1C1 RAB27B UHRF1 MOV10 POLA2 NCEH1 MAPK7 STRN ANP32B MYLIP RNP24 GFM1 MAGT1 PANX1 COIL COL1A1 SERP1 DHX15 COL3A1 GNPNAT1 TMED7 MRPS24 ELMOD2 TMT1A PSAT1 AP3B1 CSDE1 SSNA1 NAPG NT5E PGRMC1 PPP1R7 MPZL1 SPRYD4 CDKN1B TTC9C SPCS3 TPPP3 GPAM NFIA AXL SNX15 PKN2 LAMTOR5 TMEM87A SLC25A13 VSNL1 FAR1 FSTL1 LTN1 CAMTA1 ABHD10 DSG2 POGLUT3 KPNA3 BACH1 RARS1 ATG9A STX7 UBE4A CDKAL1 RAB30 SYPL1 ADAR GPD2 NCL PLK1 PTMAP7 GEMIN7 SRSF9 RAI14 SDCBP SLC4A10 GNL3L COL1A2 P4HA2 CHMP2A SRPRB DKFZp761E1322 PICALM DOCK5 CALCOCO2 DOCK7 CYR61 SYNE2 SYNE1 SNAP29 HSDL1 RCN2 RBMS1 SEC23A LUZP1 NUFIP2 NXN HSD17B12 GNA13 TP53INP1 ASH2L SH3BP4 ZNF622 PDLIM7 SLC25A24 SLC12A2 GALNT7 NHERF2 TM6SF1 SLC4A7 CPOX RQCD1 SLC25A32 LPL BET1 EGFR CYP1B1 GALNT1 NRP1 ERBB3 HEL-S-273 HEL-S-108 TPM3 MAPK14 MAPK12 TPM1 KRAS LAMTOR3 GSTM4 IRS1 CYP51A1 EIF4E NOTCH2 ARID1A ERG PDE3A RB1 E2F3 LMNB2 CCND1 TGFBR2 ERBB2 MET AMIGO2 BCL2 PTPRF FADS2 CTNNB1 HES1 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260410%WP4147%HOMO SAPIENS PTF1A related regulatory pathway CTNNB1 KAT2B RBPJ PDX1 NKX6-1 NOTCH1 PROX1 FGF10 PTF1A RBPJL HES1 CHOLESTASIS%WIKIPATHWAYS_20260410%WP5238%HOMO SAPIENS Cholestasis ABCC3 SCARB1 ABCC2 EPHX1 NR1I3 ATP8B1 ABCB4 SLCO1A2 LDLR ABCB11 HMGCR RXRA NR1H4 SLC22A1 ABCG8 ABCG5 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260410%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex PWWP2A H3C15 RRN3 TAF1D EP400 MTA2 H4C9 MBD2 HIST1H4L GATAD2B GATAD2A CDK2AP1 HIST1H2AB SRCAP ASF1B H2BC15 HDAC2 HDAC1 UBTF MBD3 TAF12 EP300 RBBP4 H2AX POLR1A POLR1C POLR1D TLK2 MAPK3 CREBBP ASF1A H2AC19 H2AC14 H2BC26 SIRT7 H2BC12L H2BC21 H2BC9 H2BC8 H2AC6 H2BC3 H2BC1 TBP H2BC17 HAT1 H2BC12 H2BC13 KAT2B KAT2A H2BC14 CHD4 H2AC20 H2BC11 HIST1H2BE TAF1B H2AZ1 H2AZ2 H3C8 H3F3B H2AB1 PWWP2B CHD3 H2AJ CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260410%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260410%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MCL1 C1QBP USP9X PLEK PYCR2 UBXN1 CLPB FLJ10842 TXN2 MICOS13 OPA3 STAT2 GDAP1L1 PMPCA UBXN6 PAM16 OXA1L PPA2 TMEM126A YME1L1 MICU1 SPG7 MFF TIMM50 MSTO1 MARCHF5 DNAJC19 ATAD3A TIMM8A GFER COQ5 COQ3 NPLOC4 SFXN4 RTN4IP1 TXNRD2 HSPD1 PMPCB PARK2 PITRM1 MIPEP SACS OPA1 PINK1 MFN1 MFN2 TIMMDC1 CLPP LONP1 AIFM1 TRAK1 UFD1L XPNPEP3 VCP HTRA2 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260410%WP134%HOMO SAPIENS Pentose phosphate metabolism RPIA RPE HEL-S-304 HEL107 CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies EGFR F2RL1 IFNG IL-21 DHODH IL2 TNF ITGA4 ITGB7 IL15 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260410%WP4155%HOMO SAPIENS Endometrial cancer PTEN MYC PIK3R2 PIK3R1 BAD FOXO3A FGFR1 PIK3R3 PIK3CA HEL-S-28 PDPK1 GSK3B CCND1 CASP9 AKT3 CDKN1A AXIN1 APC ERBB2 EGFR GADD45B GADD45A FGFR3 GADD45G CTNNA1 ARAF CTNNA3 BAK1 APC2 NRAS CTNNA2 MAPK1 FOS HRAS MAPK3 AXIN2 EGF BAX MAP2K1 FGF2 MAP2K2 BRAF GRB2 KRAS SOS1 RAF1 SOS2 PIK3CD POLK CTNNB1 TCF7L2 TCF7L1 DDB2 LEF1 FGFR2 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260410%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling MAP3K14 CXCL8 TNF TRADD CCL5 IKBKB MAPK8 IKBKG MAPK1 IRAK1 CHUK IFNB1 RELA NFKB2 MAP3K7 PDLIM7 CCL20 NFKBIA TRAF1 NFKB1 TRAF6 REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260410%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition RAD21 ESPL1 MAD1L1 BUB1B CENPE SMC3 CDC20 SMC1A MAD2L1 PTTG1 STAG1 APC VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2877%HOMO SAPIENS Vitamin D receptor pathway SULT1C2 ATP2B1 MYC CDKAL1 CDKN2B IRF8 CDKN2C LGALS9 CTLA4 TRPV6 DND1 CDKN2D G0S2 CCNC S100A6 MED9 LPGAT1 GXYLT2 KRT71 IGFBP1 SLC34A2 S100A2 TNLG2B LCE1F LCE1D LCE2B CDC34 NINJ1 COL13A1 HNF1A CRACR2A CRACR2B BCL6 BTLA KRTAP4-1 CDKN1A SLC37A2 KRTAP12-2 CYP2S1 PNOC CLPTM1L ALPG PTHLH ZNF257 SPRR1B ORM1 ORM2 CYP3A4 DUSP10 DACT2 KRTAP5-1 CA9 ABCD1 KRTAP5-4 S100A8 KRT34 CEACAM1 KRT38 SATB1 FOXO1 HEL57 SEMA3B ASAP2 CST6 CST1 MX2 EPHB4 CYP1A1 CLMN CREG2 LRRC25 S100G IL25 KRTAP10-2 CDKN2A KRTAP10-4 SLC2A4 KRTAP10-7 KRTAP10-9 KRT13 SULT2A1 CCNE1 CDX2 MYO9B DEFB132 CDK2 KRT16 CD9 ADRB2 LRP5 TPM1 MXD1 BGLAP PTH TNFSF11 ADAMTS5 TNFRSF11B TIMP3 SLC8A1 BMP6 EFNA5 FGF23 NFATC2 CASP14 SOSTDC1 CBS ALOX5 IGFBP5 CAMP CASP5 DEFB4B CYP27B1 NR1i1 KNG1 CYP24A1 S100A4 HSD17B2 CEBPA CLDN2 KLK6 TGFB1 KRTAP8-1 ABCB1 TRPV5 PRDM1 CD200 ITGAM CCND1 ID4 TNFAIP3 TREM1 THBD CLEC16A DNER PRKCQ IL12A GADD45A CYP2C9 ID1 KL CYP2B6 HILPDA PTGER4 HLA-DQA2 HLA-DQA1 RXRA CYP7A1 HLA-DRB1 STEAP4 SFRP1 ADRA1B TRAK1 CD40 KLF4 S100A9 CDKN1B IRF4 SPP1 CD14 JUNB NR1C2 SALL4 BDKRB1 ALPI ADGRE5 STS HIF1A COLEC11 IL1RL1 AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260410%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells GLS PSAT1 PHGDH SLC7A11 PSPH PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260410%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence ALOX5 PTGS2 IGFBP5 ALOX15B NRAS ALOX5AP PTGER4 PTGER1 HRAS PTGER2 SIRT1 PTGER3 PTGIS PTGS1 KRAS PTGES PRXL2B RB1 ALOX15 ADCY3 ALOX12 GNAI1 MAPK11 LTC4S CDKN1A GNAS PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260410%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart CALM1 MYEF2 GATA4 MAPK11 MAPK8 EDN1 PRKCB PRKCE ARHA STAT3 MAPK1 FOS IL6ST RAC1 CTF1 MAP2K3 CAMK2D JUN PPP3CA MAPK14 NFATC4 CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260410%WP2795%HOMO SAPIENS Cardiac hypertrophic response MAP2K5 NFATC2 CDK7 MTOR PRKG1 TGFB1 MAP3K14 PDPK1 GSK3B IGF1 TNF MAPK8 IKBKE CHUK MAP3K7 MAP4K1 TGFBR1 HDAC9 PRKD1 NPPA PLA2G2A HDAC7 MAPK7 HDAC5 CDK9 IKBKB IKBKG MAPK1 MAP2K6 MAPK3 EGF MAP2K3 MAP2K4 PPP3CA MAP2K1 MAP3K1 GUCA1A FGF2 MAP2K2 NFKB1 TNFRSF1A MAPK14 CALM1 RAF1 NRG1 PRKCA RAC1 FGFR2 CAMK2D HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260410%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway TFAP2A TP63 IRF6 ARHGEF2 ARHGAP29 ARHA GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260410%WP4157%HOMO SAPIENS GABA metabolism aka GHB GLS GLS2 PON3 HEL-S-166mP ABAT ADHFE1 GAD2 GAD1 ALDH5A1 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260410%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway NQO1 TGFB1 BMP2 COL2A1 FGF7 NRF1 CDC37 EXOC6 SUV39H1 PKD1 SIRT1 IGFBP7 NFE2L2 HEL-S-7 DDR1 ECSIT LOXL4 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260410%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling ATF2 BCL2 RPS6KA3 EIF4E MAP3K10 MAPK1 FOS MAP2K6 MAPK3 MAP3K11 MAP2K3 MAP2K4 JUN DDIT3 MAP2K1 MAP3K1 MAP2K2 MAPK14 MAPK12 IFITM2 MAPK10 RPS6KA1 RAF1 IFITM3 JUNB MAPK8 MAPK11 RPS6KA2 IFI27 BST2 MAPK9 IFITM1 MAPK13 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome PRKAA2 FMO5 KIRREL1 TJP1 AFDN PRKAA1 PRKAB2 PRKAB1 F11R ACP6 AMELX CHD1L NBPF12 PYGO2 TJP3 PRKAG1 PYGO1 PRKAG2 BCL9 GJA1 GJA3 CTNNB1 PRKAG3 GJA5 GJA8 PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260410%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function PDE6D ADCY1 ADCY8 ADCY6 PDE8A ADCY9 PDE1C PDE3B GUCY1A2 GUCY1B1 PDE1B CHRNA7 GRIN1 PDE1A PDE4B PDE3A ADORA2A PDE4A PDE5A PRKG1 PDE7B PDE7A PDE11A PDE4D PDE6C PDE6A PPP1R1B DRD2 PDE6H ADCY3 PDE6G PDE10A PDE12 PDE9A DRD1 HEL-S-7a CAMK2A PDE2A GRIN2B CREB1 PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260410%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway UBA7 PARK2 UBE2G1 UBE2G2 SNCAIP CYCS LRRK2 UBB PINK1 CCNE1 SLC6A3 MAPK14 MAPK12 UBE2L6 CASP2 CCNE2 SNCA GPR37 EPRS1 CASP9 MAPK11 SYT11 CASP6 UBE2J2 CASP3 SEPT5 HEL-117 HEL-S-67p HTRA2 DDC UBE2J1 TH ATXN2 APAF1 MAPK13 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260410%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy PIK3R4 ATG3 RB1CC1 ATG10 ATG12 MAP1LC3A WIPI1 ATG16L1 ZFYVE1 ATG16L2 MTOR ULK2 ULK1 ATG5 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260410%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging IGF1R PTEN MTOR SIRT1 FOXO1 GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260410%WP2261%HOMO SAPIENS Glioblastoma signaling MAP2K5 CDK6 PTEN PIK3R2 PIK3C2G PIK3R1 PIK3C2A FOXO4 CBL CDKN2B PRKCZ PIK3C2B MSH6 MDM4 PLCG2 CDK4 CDKN2C FOXO3A PLCG1 SPRY2 FGFR1 PIK3CA IGF1R RB1 PDPK1 CCND1 AKT3 PRKCQ CDKN1A ERBB2 MET EGFR EP300 ERBB3 CCND2 BRCA2 FOXO1 ARAF NRAS NF1 TSC1 MAPK1 HRAS CDKN2A MAP2K6 MAPK3 MAP2K3 MAP2K4 CCNE1 MAP2K1 CDK2 MDM2 MAP2K2 BRAF GRB2 ATM KRAS BRCA1 RAF1 ERRFI1 CDKN1B PDGFRA TSC2 IRS1 PIK3CD PRKCH PRKCB PRKCA PRKCI SRC FGFR2 NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260410%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification CALU FGFR3 JAG2 PLAT SOX6 ITGA1 MGP ALPL GJA5 NOTCH1 LPAR1 DLL3 DLL4 VEGFA MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260410%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms SGMS1 YWHAQ YAP1 CTNNA1 PAK6 NF2 MAP4K3 PAK4 ITGB5 ITGB1 ITGB4 ITGB8 ITGB7 HEL-S-31 ACTG2 ITGB6 MAPK10 WWTR1 ACTA2 ITGB3 ACTG1 MAPK8 LIMD1 PAK1 CTNNB1 PS1TP5BP1 SRC TEAD2 LATS1 TEAD3 MAPK9 TEAD4 MAP4K1 MAP4K2 ACTA1 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260410%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy TGFB1 STAT3 MYEF2 RASGRF1 PPP3R1 NFKB1 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260410%WP4217%HOMO SAPIENS Ebola virus infection in host ACTN1 RIGI CTSL CAV3 TIAM1 VPS39 PIK3R3 PIK3CA IGF1R FLNA FLNB HAVCR2 VAV2 EGFR RHOB NPC1 EP300 MAPK1 MAPK3 VPS4A CREBBP ACTN4 ITGB3 HLA-G PIK3CD SCIN CLEC10A ICAM3 RAC1 KPNA1 CD300A RFC1 TIMD4 CD209 CLEC6A ASGR1 IQGAP1 HAVCR1 HLA-DQB2 DAB2IP MBL2 RAB9A CAV2 RAB5A TYRO3 C1QBP PIK3R2 PIK3R1 SOCS3 CLEC4M EIF2AK2 CDC42 ICAM2 STAT1 ARHA RASA2 NEDD4 CLTCL1 HLA-B NFKB2 REL MERTK HLA-C HLA-A VPS11 HLA-F VPS16 ITGB1 VPS18 VPS33A HLA-E VPS41 HLA-DMA ACTG1 ITGAV ITGA4 ITGA2 PAK1 ITGA1 TBK1 PS1TP5BP1 BST2 IKBKE CLTC ADAM17 CLTB RELB PRKRA ITGA6 CLTA IRF3 EIF2S1 IRF7 TLR4 MFGE8 HLA-DOA HLA-DOB HLA-DPA1 HLA-DQB1 HLA-DMB HLA-DQA2 HLA-DQA1 HLA-DRB5 NPC2 HLA-DPB1 HLA-DRA HLA-DRB1 NFKB1 RAB7A IL4 TFAP2A AXL TSG101 RELA FOLR1 FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders PTH FGFR3 KL DMP1 ROS1 SPP1 CCND1 ENPP1 SLC34A1 CYP27B1 CYP24A1 ALPL FAM20C SLC34A3 CDKN1A NFKB2 FGFR2 CYP11B2 NFKB1 GALNT3 ORAI1 FGF23 FOXP3 IN COVID 19%WIKIPATHWAYS_20260410%WP5063%HOMO SAPIENS FOXP3 in COVID 19 STAT3 IL6ST FOXP3 CD80 IL6 IL2RG IL2 STAT5B IL7R IL2RA IL2RB IL6R TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260410%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling IKBKB MAPK1 MAPK3 NFKB2 JUN TRAF1 NFKB1 TRAF5 MAPK14 RIPK1 MAP3K14 BIRC2 BIRC3 HDAC1 RAF1 GSK3B TNF MAPK8 NFKBIB CASP8 TRIM63 CTNNB1 TRAF2 CASP3 RAC1 CHUK RELA FADD TNFRSF12A MAPK9 MAP3K7 RELB NFKBIA TWEAK TRAF3 GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260410%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GCG GIP TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260410%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NMRK1 TDO2 AADAT HAAO AFMID NMNAT1 NAPRT KYNU NMRK2 NAMPT KMO NADSYN1 NMNAT3 NMNAT2 IDO1 HEL-S-90n VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260410%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism LPL RETSAT SCARB1 DHRS3 RBP7 RBP2 CYP2E1 CD36 NR1B3 MAPK1 CYP26A1 CYP26B1 RXRB RXRA RXRG ABCG8 ADH1A NPC1L1 ABCG5 DGAT1 SULT2B1 SDR16C5 SULT1A1 RDH8 HEL-S-53e RLBP1 AWAT2 RPE65 BCO1 RDH12 RDH10 RARA ALDH1A3 RBP1 RDH5 LRAT HEL-S-4 CRABP2 CRABP1 ALDH1A2 RARB RBP4 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260410%WP3924%HOMO SAPIENS Hfe effect on hepcidin production TMPRSS6 ID1 HFE2 HFE HAMP BMP6 ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260410%WP5293%HOMO SAPIENS Acute myeloid leukemia MYC PIM2 PIK3R2 PIK3R1 CEBPE BAD EIF4EBP1 IL3 STAT3 MTOR ZBTB16 RPS6KB1 CEBPA PIK3R3 FLT3 PER2 PIK3CA BCL2A1 ITGAM CCND1 PML AKT3 FCGR1A CHUK KIT MPO IKBKB ARAF IKBKG NRAS MAPK1 HRAS MAPK3 MAP2K1 RPS6KB2 MAP2K2 BRAF NFKB1 CSF2 SPI1 GRB2 KRAS SOS1 RAF1 SOS2 RARA CD14 JUP NR1C2 PIK3CD PIM1 TCF7L2 RUNX1 TCF7L1 CCNA2 CSF1R RELA LEF1 STAT5B RUNX1T1 PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260410%WP4224%HOMO SAPIENS Purine metabolism and related disorders RRM2B HPRT1 MOCOS DGUOK AOX1 TPMT AMPD1 PFAS APRT XDH PAICS PNP ADSL IMPDH1 HEL-S-70p ADSS ADA 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260410%WP5546%HOMO SAPIENS 22q11 2 distal CNV RPS17 RPS16 RPS19 SNW1 RPS18 CD79A RPS11 RPS10 SNRNP200 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPSA PPIB RPS15A RPS3 RPS2 RPS27A RPS26 LRP4 RPS28 RPS29 RPS20 FAU RPS21 RPS24 RPS23 CAMK1 MAPK1 IQUB PTPA MDM2 ROPN1L RSPH6A NME5 HEL-S-125m SNRPB2 AQR DYDC1 BCR CAMK4 ELOC RSPH14 RPS6 CBL RNF19B VPREB1 SNRPD2 RBX1 SNRPD1 CWC22 SNRPD3 CRNKL1 PDIA4 RAB36 SNRPG PPIE SNRPE NEDD4 SNRPF SNRPB UBA6 CABP1 DNAJB13 PRPF8 AK8 CWC15 WDR57 TDRD3 GGTLC2 ZNF280A DHX16 HEL-S-107 ARIH1 CCDC116 BUD31 HYOU1 PLRG1 IGLL1 YDJC CANX SNRPA1 RBM22 SF3B5 SF3B2 PPM1F RNF113A PAK1 RILP UGGT1 PPIL1 SF3A1 SF3A2 CDC5L IGLL5 PHF5A YPEL1 RSPH9 PPIL4 PPIL6 RSPH3 PARK2 CD79B CHEK1 SDF2L1 XBP1 GNAZ PDIA2 DNAJB11 UBE3A HEL-S-89n SOX9 SF3B1 HEL-S-99n CAMK2A RPS15 XAB2 RPS14 TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260410%WP1584%HOMO SAPIENS Type II diabetes mellitus PRKCZ TNF IKBKB IRS1 INSR MAPK8 MAPK1 PDX1 MTOR MAFA PHKA2 SLC2A4 SURF1 INS-IGF2 SOCS4 PIK3R5 SLC2A2 CACNA1A IL3 SIGNALING%WIKIPATHWAYS_20260410%WP286%HOMO SAPIENS IL3 signaling IL5RA PIK3R2 YWHAQ PIK3R1 BCL2 CXCL8 CBL BAD IL3 FYN INPP5D MAPK1 STAT3 PTPN11 FOS HRAS ENPP3 MAPK3 PTPN6 JUN MAP2K1 BCL2L1 IL3RA TGFB1 CSF2RB LYN GRB2 SOS1 RAF1 HEL-S-1 PIK3CD MAPK8 CRKL SYK SRC JAK1 CD69 GAB2 CCR3 VAV1 STAT5B RAPGEF1 ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260410%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria COX11 ATP5PB ATP5F1D ATP5F1E ATP5PO NDUFB9 UCP2 UCP3 SDHC SDHD SDHA SDHB SLC25A5 UCP1 SLC25A4 SURF1 NDUFA12 ATP5IF1 NDUFC2 ND3 NDUFC1 SLC25A14 NDUFS6 ATP5J NDUFS5 ATP5H NDUFS4 SLC25A27 NDUFS3 ATP5MG ND1 ATP5MF NDUFS1 ATP5ME DMAC2L ND2 ND5 ND4 ND6 NDUFB8 NDUFB7 NDUFA11 NDUFB10 COX6A1 NDUFB6 COX6A2 NDUFB5 SLC25A6 NDUFB4 COX6B1 NDUFB3 COX7A2L NDUFB2 UQCRC1 NDUFB1 COXFA4 UQCRC2 NDUFV3 UQCRB NDUFV2 COX7A2 NDUFA7 COX7A1 UQCRH COX3 NDUFA6 COX17 ZNF183 NDUFA3 UQCRQ COX7B NDUFA2 COX4I1 ND4L ATP5G1 COX7C SCO1 NDUFA9 CYB HEL-S-271 NDUFA5 NDUFAB1 COX8A NDUFS8 UQCR11 UQCR10 COX5A NDUFA13 UQCRFS1 ATP8 ATP6 ATP5MC2 ATP5MC3 NDUFA10 HEL-S-123m COX2 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260410%WP2636%HOMO SAPIENS Common pathways underlying drug addiction PPP1CC GJB1 ADCY1 ADCY8 RAP1A ARAF PRKACG MAPK1 MAPK3 GRIN1 MAP2K1 MAP2K2 ACTG2 HEL-S-80p CALM1 RAF1 DRD2 ACTG1 GNAI1 DRD4 CAMK4 PRKCB PRKCA PS1TP5BP1 DRD1 GRIA2 PPP1R1A GNAS GRIA3 CAMK2A GRIA4 CREB1 TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260410%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta MIA3 TMEM38B COLGALT1 IFITM5 CRTAP P3H2 P3H1 LOX PLOD2 BMP1 COL1A1 COL1A2 P4HA2 PLOD1 ADAMTS2 P4HA1 PPIB LRP5 LRP6 TNFSF11 TNFRSF11B WNT1 SP7 MBTPS1 FZD1 TNFRSF11A MBTPS2 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260410%WP2369%HOMO SAPIENS Histone modifications H3C15 H4C9 HIST1H4L EZH2 MLL2 AEBP2 KMT2E SETD4 SETD3 SETD8 SMYD5 SETD9 SETD6 KMT2B DOT1L PRDM2 SMYD2 KMT5B SET EHMT1 SMYD4 SMYD3 H4C7 KMT5C SETD1B SETD1A SETDB2 SETMAR ASH1L SETBP1 KMT2A SETDB1 SETD5 SETD2 EED EZH1 SUV39H2 SUV39H1 SETD7 KMT2C SMYD1 H3C8 H3F3B LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260410%WP5146%HOMO SAPIENS Lung pathology of COVID 19 CSF2 CGAS MITA TLR3 TNF IFIH1 CXCL11 MAVS IL18 CCL2 RIGI CXCL9 TBK1 IL1B IL6 TLR8 IRF3 NFKB1 TLR7 TRANSLATION FACTORS%WIKIPATHWAYS_20260410%WP107%HOMO SAPIENS Translation factors EEF1A1 EIF5A EIF6 EIF4EBP1 EIF2AK2 EIF4A2 EIF4E EIF4B PABPC1 EIF4G1 EIF3S3 EIF3F GSPT2 EIF3D SUI1 EEF1B2 EIF3CL EIF4EBP3 EIF2B1 EIF2B3 EIF4A1 PAIP1 CLUH EIF1AY EIF3A EIF1AX EEF1G EIF5 EIF2AK1 EIF2S3 EIF3S2 EEF1A2 EIF3J EIF3G ETF1 EIF3E EIF3C EIF4EBP2 EIF2B5 EIF3B EIF2B2 EEF2K EIF2S2 EEF2 EIF2S1 EIF5B EIF4H OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260410%WP1434%HOMO SAPIENS Osteopontin signaling MAPK1 MMP9 MAP3K14 CHUK MAPK3 RELA ITGB3 MAP2K1 SPP1 IKBKB ITGAV NFKB1 MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies S1PR5 S1PR4 MS4A1 ITGB1 BTK HEL-S-171mP ITGA4 S1PR1 S1PR3 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260410%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms TMPRSS2 ACE2 AGTR1 MGRA REN IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260410%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity FCER1A IL1R1 MMP9 MYD88 PLA2G7 HBEGF S100A9 TIMP1 F2R IL18 CCL2 IRAK1 HEL-S-134P IL1B F2 IFNG TLR1 CCR3 NFKB1 NLRP3 PIK3CA DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260410%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development HES5 CDK6 DCAF7 PSENEN DYRK1A CDK4 MTOR SPRY2 NEUROG2 AMPH NFATC1 CRY2 TFDP1 TFDP2 GSK3B RBL2 CCND1 CASP9 DNER CASP3 LATS2 AKT1S1 EIF2B5 REST RBL1 LIN9 E2F5 RBBP4 FOXO1 TSC1 SIRT1 APP E2F4 FGF2 DEPTOR CDKN1B TSC2 RPTOR MLST8 PSEN1 NOTCH1 CSNK1A1 LIN54 GMNN H3F3B LIN52 CREB1 TFDP3 BACE1 LIN37 HES1 TFAP4 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260410%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease DMPK HP1BP3 HSPB3 HEL25 MYOD1 tmp_locus_29 NOTCH3 MEF2C LMNA H2AZ1 LBR MYOG ACTA1 HSPB2-C11orf52 FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260410%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling PLG TLR4 MYD88 IKBKB HEL-S-78p CCL2 IKBKG ARHA NOS2 IL6 REL NFKB1 IRAK2 PIK3CA LBP TICAM2 ITGAM PLAT TLR3 LY96 TNF CD14 FGA FCER1G SYK CXCL3 IRAK1 SRC TYROBP CHUK IL12B IFNB1 RELA IRAK4 TICAM1 TIRAP IRF3 TRAF6 METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260410%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid FADS1 ALOX5 PTGS2 ALOX15 FADS2 ALOX12 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260410%WP5390%HOMO SAPIENS Pancreatic cancer subtypes GPR87 SPRR3 ANXA8L1 ST6GALNAC1 HEL136 FAM83A PLA2G10 TFF2 KRT20 LGALS4 LYZ VSIG2 AGR2 AGR3 FAM3D CST6 KRT6C SERPINB3 BTNL8 REG4 KRT7 ANXA10 LEMD1 CEACAM6 SCCA2 LY6D TFF3 TFF1 VGLL1 CLRN3 KRT6A DHRS9 SCEL S100A2 AREG CYP3A7 TNS4 FGFBP1 CDH17 SPRR1B TSPAN8 ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260410%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism CD36 APOB LDLR ABCA1 APOA4 HMGCS1 FABP2 HMGCR MTTP TM7SF2 HSD17B7 SAR1B ABCG8 SLC27A4 NPC1L1 ABCG5 DGAT1 MGAT1 ACAT2 IDI1 FDPS MVK CYP51A1 DHCR24 MSMO1 SQLE EBP PMVK SC5D MVD DHCR7 LBR FDFT1 PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway PARP1 MIF AIFM1 GLYCINE METABOLISM%WIKIPATHWAYS_20260410%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260410%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260410%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation DCTN6 CDK5 DCTN5 YWHAQ DCTN1 DCTN4 HEL2 HEL-S-77 HEL-S-1 YWHAG NDEL1 DYNC1H1 YWHAZ PAFAH1B1 DISC1 DBH DDC DCTN3 TH PPP2CA FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260410%WP5428%HOMO SAPIENS FGFR4 p G388R signaling FGFR4 STAT3 IL10 CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260410%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia IL1A EP300 SMAD2 IKBKB MAP1LC3A IKBKG ACVR2A STAT3 FOXO3A MTOR NFKB2 IL6 REL CEBPB NFKB1 IL6R TNFRSF1A GDF8 IL1R1 IGF1R IGF1 TNF MAPK11 RPTOR TRIM63 FBXO32 MLST8 JAK1 CHUK IL1B SMAD4 RELA TNFRSF12A AKT1S1 RELB NFKBIA TWEAK PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260410%WP4022%HOMO SAPIENS Pyrimidine metabolism ENPP3 ENTPD1 ENTPD3 NME3 CTPS2 CTPS1 NME4 DCTD NME6 CMPK1 CMPK2 UPRT DCTPP1 POLR2J3 DUT DTYMK POLR2J2 POLR3A POLR3B POLR3D POLR3H NME7 POLR3K POLA1 RRM2 NME2 POLR2A POLR2B POLR2D CAD POLR2G POLR2H POLR2I RRM1 RRM2B POLR2J DPYS POLR2K DPYD POLR2L HEL74 UMPS PRIM2 TYMP NT5M DHODH POLA2 ZNRD1 ENPP1 POLR1A POLR1C POLR1D POLR1F POLR3E CDA TYMS TK1 PNPT1 UCK2 POLR2C UCK1 PRIM1 POLR3GL POLE4 POLD3 POLR3C POLD4 POLR3F POLR3G POLD2 POLE POLE2 POLE3 CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260410%WP5603%HOMO SAPIENS Caffeine in myocytes MYH2 MYL11 HEL-S-273 MYL6 TNNI1 RYR3 TNNI2 TNNI3 HEL-S-108 RYR1 ACTG2 TPM3 TNNC1 TPM1 TNNC2 ACTA2 MYL1 TNNT1 MYL2 MYL3 RYR2 TNNT3 MYH8 ACTG1 MYH6 MYH13 PS1TP5BP1 MYH1 MYH4 MYH7 ACTA1 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260410%WP4707%HOMO SAPIENS Aspirin and miRNAs NR1C1 MVD PTGS2 PTGS1 WNT1 NFKB1 VEGFA MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260410%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids CERK TSC1 IGF1R SPHK2 MTOR ASAH2 HIF1A CERS1 NFKB1 S1PR1 PIK3CA S1PR3 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260410%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis ABAT SDCBP GRIK2 CABIN1 HDAC10 STIM1 ORAI1 FFAR1 PLCB1 MBD5 EFNB2 FRMPD3 ADARB1 SLC6A13 SLC6A12 NETO2 CPEB3 GRM6 NPTN ADIJ PPP2CA ADII ARHGEF9 SLC7A11 CACNG8 NWD1 SNX27 ERBB4 CACNG2 ATAD1 SYVN1 LHFPL4 SNX14 HOMER1 MAPK1 DLG4 MAPK3 MAP2K1 CREBBP SUMO1 CDH2 HEL-S-162eP AP2A1 GAD1 STAT1 STAT3 GRM3 GABRB3 GABRB2 GABRB1 AP2A2 HDAC1 GABRE GABRQ GABRA2 GABRP SLC12A5 GABRA6 GABRA5 GABRA4 PIG59 GABRA3 GABRG3 GABRG2 GABRG1 ARC CRTC1 GRIA2 GRIP1 SLC1A1 SLC1A2 SLC1A3 GRIA3 GRIA4 GRIN2B GRIN3B GRIN3A GRIK5 GRIK3 DKFZp762B153 GRIK1 GRM2 GRM4 GRM8 GRIN1 SH3GL2 PDIA2 SLC6A8 SLC6A1 SLC32A1 SLC6A11 NRG1 PRKCA NRXN3 GABRR3 GLS2 SRC GABRR1 DLGAP3 CAMK2A GNA11 PICK1 FANCONI ANEMIA%WIKIPATHWAYS_20260410%WP5465%HOMO SAPIENS Fanconi anemia EGFR UHRF1 PTEN DCLRE1B UHRF2 REV1 BRCA2 FANCM FANCL FANCB FANCE FANCF ATR RAD51C FAN1 FAAP24 CENPX FANCD2 MAD2L2 CENPS MCM2 USP1 CEBPD HEL-S-125m RAD50 SLX4 BRIP1 MRE11A ATM BRCA1 MEN1 NBN FANCA PALB2 RAD51 UBE2T RFWD3 FANCG CTDP1 FANCC ERCC1 SMARCA4 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2542%HOMO SAPIENS Sulindac metabolic pathway MSRA CYP1B1 MSRB2 MSRB3 AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260410%WP1403%HOMO SAPIENS AMP activated protein kinase signaling NR2A1 PIK3R2 PIK3R1 EIF4EBP1 INSR PRKACG PRKAA1 MTOR PRKAB2 RPS6KB1 PRKAB1 HMGCR PIK3R3 FASN ACACB ACACA CRTC2 STK11 PIK3CA LEP PLCB1 ADIPOR2 STRADA PPARGC1B PRKAG1 PRKAG2 CPT1C PRKAG3 CDKN1A EEF2K INS-IGF2 EEF2 ELAVL1 GYS1 PRKAA2 LIPE SLC2A4RG CAMKK1 CAMKK2 STRADB TSC1 SLC2A4 RPS6KB2 GYS2 ADRA1B LEPR ADRA1A ADIPOR1 TSC2 CAB39 PIK3CD RPTOR CPT1A CCNA2 CCNB1 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260410%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members PARP10 EP300 ZC3HAV1 TIPARP MAVS IKBKB PARP16 RBX1 PARP12 RIGI IKBKG BTRC ERN1 NFKB2 CLDN6 TFPI2 CREBBP MAP3K14 PARP14 GSK3B TBK1 CHUK SKP1 RELB NFKBIA PARP1 NRF2 PATHWAY%WIKIPATHWAYS_20260410%WP2884%HOMO SAPIENS NRF2 pathway UGT1A9 FTH1 SLC39A8 SLC39A14 SLC6A2 EPHA2 SLC6A3 SLC5A7 HEL-S-10 GCLM SLC6A13 SLC7A11 SLC5A2 SLC6A20 NQO1 GSTM1 UGT1A3 SLC5A5 HBEGF KEAP1 SLC6A19 SLC6A18 HMOX1 GCLC SLC6A17 SLC6A16 SLC5A6 ALDH3A1 SLC5A8 SLC5A9 CES8 CES3 EPHA3 SLC5A3 SLC2A4 SLC5A4 SLC2A9 SLC6A5 SLC6A7 ABCC5 MAFF SRXN1 DNAJB1 UGT1A4 NFE2L2 SLC2A6 CYP2A6 SLC2A2 SLC2A7 SLC2A8 SLC5A1 SLC2A11 SLC2A10 SLC2A13 HEL-S-25 UGT1A1 SLC5A12 SLC5A10 SLC39A9 SLC39A6 SLC39A5 GSTM4 SLC39A2 GSTM3 SLC39A1 GSTM2 SLC39A3 GPX2 GSTM5 GPX3 MAFG SLC39A11 SLC39A10 SLC39A13 HEL-75 SLC39A12 TXN HEL126 AGER CES2 SLC2A12 CES1 GSTT2 FGF13 HSP90AB1 TGFB1 ABCC3 HEL-S-128m ABCC2 TXNRD3 SLC2A14 ADH7 FTL UGT1A7 HGF TGFA MGST3 TGFBR2 MGST2 SLC6A9 SQSTM1 SLC2A3 RXRA GSTA5 GSTA4 GSTA3 SERPINA1 SLC6A8 SLC6A1 SLC6A11 ME1 NRG1 NR1C2 PTGR1 CYP4A11 HEL-S-22 UGT2B7 EGR1 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260410%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP27B1 CYP24A1 CYP17A1 CYP4F8 CYP4Z1 CYP7B1 CYP2U1 CYP8B1 CYP27A1 CYP4F22 CYP4X1 CYP11A1 CYP2J2 CYP4F11 CYP27C1 CYP2S1 CYP11B2 CYP4F3 CYP4V2 CYP3A4 CYP2R1 CYP1B1 POR CYP2E1 CYP2A7 CYP2C9 CYP2C8 CYP2B6 CYP2C19 CYB5R3 CYP2F1 CYP2C18 CYP20A1 CYP1A1 CYP26A1 CYP26B1 CYP46A1 CYP7A1 CYP3A43 CYP2A6 CYP2W1 CYB5R1 CYP2A13 CYB5R4 CYP4B1 CYB5B CYP4F2 CYP4A22 CYP4F12 CYP4A11 CYP3A7 CYP51A1 CYP26C1 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260410%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit SPN CD3G CD80 BCL2 CD27 CD3E CD3D IL2 SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260410%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ACE2 AGTR1 ADAM17 AVPR1B GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260410%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs G6PC1 PFKL LIPE GLYCTK GPD2 AGXT AQP9 PGAM1 PCK1 ALDOB FBP1 MGLL PNPLA2 GPD1 HEL-S-87p PKLR KHK ENO1 HEL-S-68p HEL-S-162eP HEL-S-49 AQP7 PC HEL-S-165mP CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260410%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling TRPC1 DAGLA PLCB1 CNR1 CCKBR CCK RYR3 RYR2 RYR1 GNAI1 DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260410%WP5175%HOMO SAPIENS Disorders in ketone body synthesis BDH1 OXCT1 ACAT1 HMGCL INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260410%WP5120%HOMO SAPIENS Inclusion body myositis PSEN2 PSEN1 SIRT1 APP NFKB2 PSENEN NFKB1 BACE1 GDF8 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260410%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system VHL HSPA4 EP400 BDNF SNCAIP SMAD2 CDC20 PRKCZ FUS FAT10 MAPRE1 HEL-S-2a BBIP1 MAP1B HEL-S-44 TARDBP SP1 ERG HDAC11 HEL-S-72p OPTN BIRC5 FOXP3 MYH9 GSK3B DLG2 HEL-S-32 SHH MIF AURKA MAPK8 FREP1 ADRBK1 CYBB GRIA2 KAT5 HEL-S-102 HDAC9 POU5F1 GSK3A TUBA1C APC TUBB PARK2 MYD88 EGFR ISG15 CD133 EP300 SQSTM1 BCL2 APOE ITIH4 TUBA4A MAP1LC3A MAP3K5 TUBA2 MAPK1 CSNK2A2 TWIST1 DLG4 HEL113 MAPK3 BAX CFTR SGK1 CSNK2B RHOT1 NR3C1 SNCA SIRT2 DCTN1 IKBKAP VCP NEDD9 KALRN ATXN3 CCDC141 MIIP PRKCE ARID3A HTT HSF1 GARS1 CTNNB1 CNOT6 RAC1 PXN HIF1A HEL-S-67p PTK2B STUB1 HDAC6 THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260410%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling TEC CRLF2 TSLP EIF4EBP1 STAT4 FYN STAT1 MAPK1 STAT3 PTPN11 MAPK3 NFKB2 MAP2K1 MAP2K2 NFKB1 MAPK14 LYN FES IL7R MAPK8 SRC JAK1 RELA MAPK9 RPS6 RELB GAB2 BTK NFKBIA STAT5B YES1 LCK PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260410%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer TFEB MAPKAP1 PTEN PIK3R2 PIK3R1 FOXO4 BAD FOXO1 EIF4EBP1 NRAS FOXO3A HRAS MTOR RHEB PIK3R3 ULK1 PIK3CA KRAS RB1CC1 GSK3B CDKN1B TSC2 RPTOR GRB10 MLST8 RICTOR HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260410%WP4540%HOMO SAPIENS Hippo signaling regulation SMAD2 PRKCZ CDC42 INSR ARHA NF2 FGFR4 PRKACG KDR PRKAA1 PRKAR1B PRKAR1A MTOR PRKAB2 PRKAB1 FGFR1 FLT1 FLT3 EPHA2 FLT4 PLCB4 IGF1R PLCB1 WWTR1 PLCB2 NGFR GNAI3 PRKAG1 PRKAG2 PRKAG3 TEAD2 LATS1 PRKCQ LATS2 TEAD3 CDH10 TEAD4 CDH11 GNAS CDH12 CDH15 CDH16 CDH17 CDH18 CDH19 KIT PRKAA2 MET EGFR FGFR3 YAP1 NTRK1 NTRK2 PRKD3 CDH9 CDH8 CDH6 PLCB3 GNAL CDH4 CDH2 PDGFRA PRKCH PRKCB PRKCE PRKCA CTNNB1 PRKCI TCF7L2 RAC1 TCF7L1 CSF1R LEF1 FGFR2 CDH24 GNA11 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling ABCC3 NQO1 ABCC2 EPHX1 KEAP1 ABCG2 CES1 GCLC HMOX1 MAPK11 MAPK8 GCLM NQO2 FOS HEL-S-22 JUN SRXN1 NFE2L2 MAPK14 MAPK13 ABCC6 MAPK12 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260410%WP80%HOMO SAPIENS Nucleotide GPCRs P2RY4 LPAR4 P2RY2 LTB4R P2RY1 ADORA2B ADORA2A P2RY6 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260410%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260410%WP2333%HOMO SAPIENS Trans sulfuration pathway CBS MTR pcap CTH GCLM SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260410%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization TGFB1 CSF2 CCR1 CCR5 IL2 IL4 CCL4 IL5 CXCR3 CD40LG CCL3 IFNGR1 IFNGR2 IL12B IL18R1 IL12A IFNG CCR7 CXCR4 CCR4 CCR3 CCR2 IL12RB1 H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260410%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer CDK8 CTNNB1 RB1 CSRP2 PMAIP1 MED1 CCND1 SOX4 MACROH2A1 CDK4 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP69%HOMO SAPIENS T cell receptor signaling CRK PIK3R2 NFATC2 PIK3R1 NCK1 CBL CDC42 FYN MAP3K8 PTPN11 PLCG1 SH2B3 REL NFATC1 MAP3K14 PDPK1 MAPK8 PAK1 ITK CHUK PRKCQ LAT MAP3K7 MAP4K1 NFKBIA CARD11 HEL-S-81p VAV3 BCL10 RIPK2 TRAF6 WAS ATF2 IKBKB IKBKG MAPK1 FOS CD3G HRAS CD3E MAPK3 CD3D JUN MAP2K1 MAP2K2 NFKB1 MAPK14 GRB2 SOS1 RAF1 CRKL GRAP2 CD8A PSTPIP1 LCP2 ICOS RELA MAPK9 PTK2B FYB1 GAB2 VAV1 ZAP70 CREB1 LCK PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260410%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies CXCL1 IL17F IL17A CXCL8 TNF IF2B1 IL23R STAT3 IL1B IL12B HLA-C TYK2 IL17RC CCR6 CCL20 IL23A IL12RB1 OVARIAN INFERTILITY%WIKIPATHWAYS_20260410%WP34%HOMO SAPIENS Ovarian infertility CCND2 ZP3 PRLR ZP2 NR1i1 CDK4 TSC1 NCOR1 MTOR PTGER2 CEBPB LHCGR FMR1 SYNE2 DAZL NR3A2 ATM CDKN1B TSC2 SMPD1 NR5A1 RAD51 TBP PGR GDF9 GJA4 FSHR FIGLA DMC1 EGR1 INHA CREB1 INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260410%WP1984%HOMO SAPIENS Integrated breast cancer pathway BLM BACH1 CHEK2 PTEN MYC SMAD2 BARD1 BAD PLK1 CDC25B MSH6 MSH2 NUP85 CDK4 NOXA1 HMGCR GRN XRCC3 AURKA RHO SMARCA4 FAU ANXA1 CERK AHR EGFR EP300 FOXO1 BMPR2 ARAF NF1 RRAS TSC1 MAPK1 SIRT1 RHEB JUN CDK2 MDM2 BRAF GDI1 RPP38 KRAS TSC2 IRS1 DAG1 RAC1 JAK1 ZMYND8 NAB1 MAX MAP3K7CL ALKBH1 RALGAPA1 CCNB1IP1 PIAS1 LGALS13 PLK3 CREB1 ERAL1 HIPK2 MYT1 FOSL2 WEE1 EDAR FER PIGR RASGEF1A SELENOK SMAD6 DCAKD PIK3R2 PKIA ITPKC USP15 USP16 USP21 RAP1A CDK7 FILIP1 CDC42 UBE2F STAT1 SP1 TPR MTOR SMAD1 STK11 HDAC1 RB1 TRADD CCND1 PML SMEK1 CASP9 RAD51 PAK1 CASP8 APOBEC3G ZNF655 CSNK1D CASP3 CHUK SMAD4 FADD PPP4R3B TGFBR1 TGFBR2 MAP3K7IP1 GSK3A GADD45A BCL2 CHEK1 BRCA2 BAK1 ATR MYCBP2 MAP3K13 BAX NFKB1 TFPI RAD50 MRE11A ATM BRCA1 RASGRP3 ZMIZ1 DHTKD1 CTNNB1 RALA VEGFA ATF1 FOSL1 BMPR1A NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260410%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer MMP2 MMP9 EGFR MET SNAI1 SMAD2 PECAM1 NRP1 PLXNA4 KDR MAPK1 COL1A1 COL1A2 SEMA3A MAPK3 EGF NFKB2 REL SNAI2 CCNE1 FLT1 MAP2K1 CDK2 PLXNA1 MAP2K2 NFKB1 CTGF CCNE2 CDKN1B AKT3 SRC PLXNA2 RAC1 SMAD4 RELA HGF RELB TGFBR1 TGFBR2 GSK3A CHD2 TGFBR3 VEGFA GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260410%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GPRC5D GABBR1 GRM2 GRM4 GRM8 GRM3 CASR GRM6 GPRC5A GPRC5C GABBR2 EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260410%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR2J GTF2F2 POLR2K TAF12 TAF13 MNAT1 CCNH CDK7 GTF2H2C_2 TAF7 TAF6 GTF2E1 POLR1A POLR1D POLR3E GTF2H2 GTF2H3 GTF2B POLR2C TAF5 HEL-S-28 POLR3B POLR3D TBP POLR3H POLR3K TAF9 ERCC2 GTF2E2 POLR2A POLR2B POLR2F POLR2G POLR2H POLR2I KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260410%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy SCN8A SCN2A SCN4B KCNQ2 RAB1A ZNF547 TRAPPC3 GIGYF1 FGF13 TRAPPC6B FGF12 KCNQ5 NEDD4 AKAP5 CALM1 SNAP25 DAG1 PRKCE STX1A RAB11A KCNQ3 VAMP2 CAMK2A PRRT2 BACE1 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome CCL3L3 MED1 PIP4K2B CCL14 DHRS11 RPL23 CCL13 TBC1D3B TBC1D3E SOCS7 TBC1D3C CCL18 CWC25 TBC1D3I CCL16 AATF IKZF3 CISD3 CACNB1 ACACA TMEM132E TBC1D3H RDM1 ARL5C C17orf50 GPR179 UNC45B SLC35G3 SRCIN1 SLFN12 PNMT SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 SLFN5 GGNBP2 PGAP3 FBXO47 MLLT6 PIGW CCT6B MRM1 FBXL20 NEUROD2 MIEN1 ZNHIT3 LYZB C17orf78 ASIC2 GAS2L2 HEATR9 TAF15 RASL10B PCGF2 SYNRG EPOP PLXDC1 NLE1 ERBB2 RFFL ARHGAP23 CCL11 TBC1D3K TEC STAC2 CDK12 SPMAP1 PEX12 CCL1 CCL5 CCL7 CCL4 STARD3 CCL2 CCL3 FNDC8 MMP28 CCL15 DUSP14 PPP1R1B GRB7 TCAP CCL8 LHX1 TCF2 CCL4L2 PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260410%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 NR3A2 MYC H3Y1 EP300 MYF5 H3Y2 PAX7 MYOD1 DUX4 PPARGC1A TRIM63 FBXO32 CDKN1A MYOG ADRB2 VEGFA RET SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260410%WP4658%HOMO SAPIENS Small cell lung cancer CDK6 PTEN LAMB4 MYC PIK3R2 PIK3R1 CDKN2B CDK4 ITGB1 PIK3R3 TRAF1 TRAF4 TRAF5 LAMC2 PIK3CA BIRC7 LAMC1 BIRC2 BIRC3 RB1 E2F2 E2F3 CCND1 ITGAV CDKN1C CASP9 AKT3 ITGA2 NFKBIB CASP8 TRAF2 CASP3 CHUK CDKN1A FHIT SKP1 ITGA6 NFKBIA APAF1 TRAF3 TRAF6 LAMA5 LAMA1 GADD45B LAMA4 GADD45A LAMA3 GADD45G BCL2 CYCS CKS2 PTGS2 IKBKB IKBKG BAK1 NOS2 LAMB3 RXRB RXRA LAMB2 CCNE1 RXRG LAMB1 BAX CDK2 BCL2L1 NFKB1 CCNE2 ITGA2B CDKN1B COL4A2 PIK3CD CKS1B COL4A1 COL4A4 COL4A3 POLK COL4A6 COL4A5 RELA DDB2 MAX RARB MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260410%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis SUOX AOX1 GPHN MOCS2 XDH MTARC2 MOCS1 OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP3941%HOMO SAPIENS Oxidative damage response GADD45A BCL2 CYCS BAD CDC42 TNFRSF1B PCNA C1S BAG4 BAK1 C1R NFKBIE C2 MAP2K4 C4B_2 MAP3K1 TRAF1 NFKB1 MAPK10 C1QB C1QA TNF CDKN1B CDKN1C CASP9 TRAF2 CASP3 CDKN1A C1QC CR2 C5AR1 C3AR1 APAF1 TRAF3 MAPK13 TRAF6 TNK2 HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260410%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias ALAS2 ALAS1 FECH UROD UROS HMBS CPOX NEPHROGENESIS%WIKIPATHWAYS_20260410%WP5052%HOMO SAPIENS Nephrogenesis BMP7 FGF8 TCF21 FOXD1 GREB1L NOTCH2 MEIS1 WNT9B RSPO3 RSPO1 SIX2 WNT3A OSR1 ALDH1A2 WNT4 FGF20 PAX2 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260410%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC6A20 SLC7A7 CLTRN SLC7A9 SLC1A1 SLC3A2 SLC6A19 SLC36A2 SLC3A1 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260410%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 SP1 MAFG CYP2E1 MAP2K1 MAFF MAP2K2 NFE2L2 MAPK8 MAFK SIGNALING LIPIDS%WIKIPATHWAYS_20260410%WP5584%HOMO SAPIENS Signaling lipids EPHX2 PLCB1 PTGES PRXL2B HPGD CYP2C9 ALOX5 CYP4F2 PTGS2 CYP2C8 ALOX15 CYP2B6 FADS2 ALOX12 CYP7B1 CYP8B1 GPX4 CYP27A1 LTC4S CYP7A1 PLA2G1B PLA1A GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5292%HOMO SAPIENS Glycosphingolipid metabolism GBA2 NEU3 UGCG NEU4 B3GALT2 GLA B3GALT1 B4GALNT1 ST3GAL5 B4GALT5 UGT8 B3GNT5 A4GALT A3GALT2 B4GALT4 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260410%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase EPHX2 CYP2J2 COX8A HEL-S-22 CYP2C9 CYP2C8 COX5A GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260410%WP661%HOMO SAPIENS Glucose homeostasis INS WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260410%WP4150%HOMO SAPIENS Wnt signaling in kidney disease NPHP3 WNT2B INVS WNT5B ARHA WNT16 LRP5 LRP6 MAPK10 DVL1 DVL2 DVL3 FZD4 MAPK8 WNT1 WNT3 FZD1 CTNNB1 WNT10B WNT10A FZD3 WNT9B FZD2 WNT3A MAPK9 FZD5 WNT4 WNT7B FZD7 FZD9 WNT7A FZD8 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260410%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer BBC3 MYC SMAD2 CSNK1A1L BAD MSH3 MSH6 MSH2 ARHA BCL2L11 REL BIRC5 TGFB1 GSK3B CCND1 CASP9 AKT3 MAPK8 TBK1 CASP3 SMAD4 CDKN1A AXIN1 TGFBR1 TGFBR2 APC NTN1 GADD45B GADD45A GADD45G BCL2 CYCS PTGS2 RAC3 ARAF BAK1 APC2 MAPK1 FOS EXOC2 MAPK3 AXIN2 BAX JUN MAP2K1 BRAF MAPK10 KRAS RAF1 PMAIP1 POLK CTNNB1 APPL1 TCF7L2 RAC1 DCC TCF7L1 DDB2 LEF1 MAPK9 RALA CSNK1A1 RALB CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260410%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway TREX1 CGAS IFNA13 ADAR IFNA14 IFNA16 MITA IFNA17 MAVS RIGI IFNA10 TRIM25 IFNA21 AIM2 IL33 IFNA1 PYCARD TRADD POLR3A POLR3B POLR3D POLR3H NFKBIB CASP8 POLR3K TBK1 CASP10 IKBKE CHUK IFNB1 FADD RIPK3 NFKBIA IRF3 POLR2F ATG5 POLR2H IRF7 POLR2K POLR2L ISG15 RNF125 IFNA4 IFNA7 CYLD IFNA6 IFNA2 CCL5 IFNA8 IKBKB ATG12 CCL4 IKBKG POLR1C POLR1D ZBP1 POLR3E IL6 NFKB1 RIPK1 POLR3GL POLR3C POLR3F NLRX1 POLR3G IL18 IF1AA9 IL1B RELA CCL4L2 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260410%WP691%HOMO SAPIENS Tamoxifen metabolism SULT1A1 CYP1B1 CYP2E1 UGT1A10 CYP2C9 CYP2C8 CYP2C19 CYP1A1 UGT2B15 UGT1A8 SULT1E1 UGT2B7 SULT2A1 UGT1A4 CYP2A6 CYP3A4 JOUBERT SYNDROME%WIKIPATHWAYS_20260410%WP4656%HOMO SAPIENS Joubert syndrome TMEM67 NPHP1 PDE6D NPHP3 BBS2 NEK8 BBS1 INPP5E TTC8 CETN2 ARHA MKS1 CEP41 MTOR TMEM138 MYO6 TMEM237 UNC119 ZNF423 AHI-1 FLNA SHH SUFU KAT5 PARP1 RAB8A TCTN3 TCTN2 TCTN1 B9D2 CEP97 CC2D2A OFD1 INVS ARMC9 RPGRIP1L CEP164 CCP110 ARR3 ARL2 PCNT RAB3IP RHEB BBS9 BBS7 BBS5 CEP290 BBS4 CPLANE1 RAD50 ATF4 TMEM231 MRE11A TMEM17 ATM B9D1 PDE6A DVL1 PDE6G RP2 DVL3 TMEM216 PIBF1 PCM1 CEP104 ARL3 ARL13B T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer TNFSF6 TNFRSF9 FAS CXCL12 NR1i1 IL13 CD40LG LGALS9 CTLA4 CCL17 VEGFB VTCN1 IL6 VSIR TNLG5A VEGFC TIGIT TNFRSF4 CCL22 VEGFD HLA-A B2M PDCD1 PDCD1LG2 FAP ENTPD1 IDO1 PDGFD PDGFC TGFB1 NT5E CD40 CD80 PDGFA IL4 SHH TNLG2B CD226 ARG1 ICOS CXCR4 IL10 HAVCR2 VEGFA SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260410%WP615%HOMO SAPIENS Senescence and autophagy in cancer GABARAPL1 RNASEL PTEN MMP14 TNLG1B INHBA IGFBP5 INS SPARC GABARAP VTN IL3 CDC25B PCNA IL24 CXCL14 IRF1 MTOR CEBPB MAP1LC3C ULK1 CXCL1 TGFB1 IGF1R KMT2A RB1 RB1CC1 GSK3B IGF1 BMI1 HMGA1 SMAD4 IFNB1 CDKN1A AKT1S1 ATG5 IRF7 IL1A BMP2 SERPINB2 SH3GLB1 DKFZp762B153 ATG3 SQSTM1 CD44 BCL2 CXCL8 UVRAG ATG10 AMBRA1 ATG14 ATG12 MAP1LC3A ATG16L1 CCL3 MAPK1 HRAS CDKN2A COL1A1 COL3A1 IL6 MAP2K3 THBS1 IGFBP7 JUN MAP2K1 MDM2 ING1 IFI16 BRAF IL6R CREG1 MAPK14 RSL1D1 COL10A1 RAF1 PLAT LAMP2 SLC39A2 CDKN1B SLC39A1 SLC39A3 MLST8 IL6ST SRC IL1B IFNG GABARAPL2 FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260410%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis CSN1S1 PRKAA2 EIF4A2 TSC2 PRKAG1 PRKAG2 EIF4E RPTOR CSN2 PRKAA1 PRKAG3 MLST8 MTOR PRKAB2 RPS6KB1 CSN3 PRKAB1 EIF4G1 EEF2K EEF2 PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260410%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling PRKAA2 MYC CD80 SLC2A3 GSK3B TSC2 HEL-S-133P PFKFB4 NR1i1 HK3 TSC1 CYP24A1 MTOR RELA IL12A RXRA IL10 HLA-DRA PDHA1 PIK3CA NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260410%WP2882%HOMO SAPIENS Nuclear receptors meta pathway UGT1A9 FTH1 SLC39A8 IP6K3 SLC39A14 UGT2B4 SLC6A2 EPHA2 SLC6A3 SLC5A7 HEL-S-10 FGF8A SLC6A13 SLC7A11 SLC7A5 SERPINB2 HBEGF KEAP1 PTGS2 FOXO1 HMOX1 SLC6A17 SLC6A16 SLC5A6 ALDH3A1 SLC5A9 CES8 CES3 EPHA3 SLC5A3 SLC5A4 SLC2A9 SULT2A1 SLC6A5 SLC6A7 ABCC5 PTPA MAFF SRXN1 DNAJB1 NFE2L2 SLC2A6 SLC2A7 SLC2A8 SLC2A11 PDK4 SLC2A10 SLC2A13 SULT1A1 HEL-S-25 UGT1A1 SLC5A12 SLC5A10 IL17B PCK1 GPX2 GPX3 MAFG IL1B HEL-75 TXN SLC2A12 NR1i1 ALOX5AP FGF13 PDE4B ABCC3 ABCC2 ABCB1 ABCB4 PPARGC1A BAAT ABCB11 CYP8B1 ADH7 SLCO1B1 SLC27A5 FTL SLC6A9 SLC27A1 SQSTM1 DBI SLC2A3 CYP2C9 CYP2B6 CYP2C19 CCL2 FABP1 SNAI2 CYP7A1 PLTP SERPINA1 ABCG8 ABCG5 GCC1 NR3C1 APOA2 APOC3 APOA5 SLC6A1 SLC6A11 SMC1A CDKN1B JUNB GPAM KAT2B CYP4A11 KLK15 SRC CPT2 ACADM EGR1 SMARCA1 NR0B2 JUND MYC CDC2 CDK4 NR1H3 NR1C1 SCD FASN IGFBP1 GCLM NCOA6 MYOF ALAS1 SLC5A2 CYP3A4 SLC6A20 NQO1 GSTM1 AHR UGT1A3 SLC5A5 EGFR CAP2 CYP1B1 EP300 EHHADH AIP SLC6A19 FKBP5 SLC6A18 GCLC CDC37 CYP1A1 AHRR SLC5A8 SLC2A4 JUN CCL20 SLCO2B1 UGT1A4 CYP2A6 SLC2A2 DNAJC7 SLC5A1 SLC39A9 SLC39A6 GSTM4 SLC39A5 GSTM3 SLC39A2 GSTM2 SLC39A1 SLC39A3 GSTM5 CYP3A7 SLC39A11 SRPX2 SLC39A10 CPT1A SLC39A13 SLC39A12 NR1H4 HEL126 AGER CES2 CES1 GSTT2 SP1 STAT3 B3GNT5 NFKB2 HSP90AB1 ACOX1 TGFB1 HEL-S-128m BIRC2 BIRC3 TNF TXNRD3 CCND1 CDKN1C TNFAIP3 SLC2A14 THBD EPB41L4B ARL5B RGS2 DNER ENC1 ANKRD1 IL12B TNS4 UGT1A7 IL12A SRGN IL11 HGF FGFBP1 TGFA EDN2 TSC22D3 MGST3 POU5F1 TGFBR2 NAV3 MGST1 TGFBR3 ADGRF4 MGST2 CDC42EP3 SCNN1A PMP2 ANGPTL4 MFGE8 SLC26A2 GADD45B ABHD2 NR1I3 AMIGO2 BHLHB2 PRRG4 FGD4 GPR153 SERTAD2 STOM NCOA1 PPP1R14C CAVIN2 PTGES3 PLK2 NR1i2 DNAJC15 KTN1 ACKR3 ZIC2 S100P SPRY1 CPEB4 RXRA BAX GSTA5 GSTA4 GSTA3 SLC6A8 ME1 IL2 NRG1 NR1C2 PTGR1 POLK CYP4F12 HEL-S-22 IFNG UGT2B7 SLC19A2 HES1 ALSTROM SYNDROME%WIKIPATHWAYS_20260410%WP5202%HOMO SAPIENS Alstrom syndrome ALMS1 IFT172 IFT27 E2F4 CEP192 RABL2B BLOC1S4 ACTN4 VCPIP1 BLOC1S6 BLOC1S1 CIMAP3 SNAPIN TFDP2 RFX2 VCP DTNBP1 RFX3 IFT25 RFX1 TUBG1 SMO DNM3 IFT81 RILPL1 GPR161 PTCH1 MYO5B STX5A IFT74 CEP19 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260410%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 EBI3 CD79A CXCL12 C4A CXCL13 IRF8 CD40LG PTPRC SH2D1A HEL-S-72p CD82 PRDM1 MAF TNF SYK ITGAX TNFSF13 BLNK BCL6 IL12A BTLA CCR7 CR2 MS4A1 IFITM1 IL10 IFIT2 TMSB10 TLR7 CD19 TLR4 MFGE8 ISG15 CXCR5 TNLG7A CD22 ICOSLG FOXO1 XBP1 CCL19 IL6 IL-21 CCL21 PDCD1 CRP TBX21 GPR183 CD40 BCR CD80 IL2 IL4 IRF4 BACH2 PAX5 AID ZEB2 FCRL5 CD1D ICOS SELL IFNAR2 SLAMF7 CD69 IFNG CXCR4 HEL-S-62p CR1 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260410%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt GH1 GNRH1 IGF1 SST GHRH NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260410%WP4753%HOMO SAPIENS Nucleotide excision repair CUL4A MNAT1 CCNH CDK7 GTF2H2C_2 RPA3 RPA1 RBX1 PCNA CETN2 GTF2H2 GTF2H3 DDB1 GTF2H5 XPA CUL4B POLE4 POLD3 POLD4 POLD2 XPC POLE RFC3 RFC4 LIG1 ERCC1 RFC1 ERCC2 RFC2 DDB2 POLE2 POLE3 ERCC5 GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism A3GALT2 ST8SIA1 FUT1 SLC33A1 B3GALT4 ST8SIA5 ST3GAL1 ST6GALNAC6 B3GALT1 B4GALNT1 ST3GAL5 INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer ADAM10 MYC CCL1 FOXO1 CCL5 CCL4 FCGR3A CCL2 CCL3 MICA TIGIT CSF2 TNF NCR1 NCR3 BMI1 CD226 IFNG PRF1 ADAM17 GATA2 KLRK1 NCR3LG1 MICB CD96 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260410%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis NR3C1 LEP PPARG PPARGC1A TNF FOXO1 IRS1 INSR MAPK8 TWIST1 SLC2A4 CEBPA IL6 RXRA CEBPB LPIN1 CREB1 CEBPD PCK2 ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260410%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260410%WP2197%HOMO SAPIENS Endothelin pathways HEL-S-14 RIIAD1 NPY ADRB1 CALCA CALCRL EDN1 MAPK1 MAP2K1 NPY1R ADRA1A MYLK PTGIR GNA15 CALM1 PLCB1 MYL1 RAF1 GNG13 ECE1 GNAI1 GNB5 PRKCA HEL-S-7a EDNRA EDNRB GNAS RAMP1 CAD ATP2A2 COX2 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260410%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 EPHX2 LPL APOA2 APOA4 GHR PCSK9 USF1 APOB LDLR LIPC GPIHBP1 PLTP DNA MISMATCH REPAIR%WIKIPATHWAYS_20260410%WP531%HOMO SAPIENS DNA mismatch repair POLE4 POLD3 POLD4 RPA3 RPA1 POLD2 PCNA PMS2 POLE MSH6 MSH2 RFC3 RFC4 LIG1 RFC1 RFC2 POLE2 POLE3 IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260410%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IL17F TLR4 IL17A CSF2 TNF STAT4 STAT1 IF2B1 STAT3 RORC IL12B IFNG TYK2 IL23A STAT5B IL12RB1 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260410%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan TDO2 HAAO KMO AFMID NMNAT1 NADSYN1 KYNU HEL-S-90n BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260410%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation FGFR4 MAPK1 FXR1 FGF8A MAPK3 SLC10A2 LDLR CYP7A1 ABCB11 ABCG8 ABCG5 DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260410%WP5178%HOMO SAPIENS Disorders of fructose metabolism G6PC1 PFKL HEL-S-53e KHK GLYCTK SORD SLC2A2 HEL-S-49 ALDOB FBP1 SLC5A1 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway NQO1 AHR UGT1A3 SERPINB2 EGFR CAP2 CYP1B1 EP300 UGT1A9 AIP NCOA1 CDC37 PTGES3 CYP1A1 ALDH3A1 AHRR CES3 BAX JUN UGT1A4 NFE2L2 TGFB1 UGT1A1 IL17B IL2 TNF CDKN1B IGFBP1 JUNB POLK SRC MYOF IL1B IL12B UGT1A7 IL12A IFNG JUND MGST1 HES1 SLC7A5 PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260410%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia GNA15 TRPC3 PLCB3 PLCB1 PLCB2 HOMER3 CA8 GRIA2 ATP2B2 RYR3 GRIA3 GRIA4 CACNA1A PLCB4 GNA11 GNA14 COPPER METABOLISM%WIKIPATHWAYS_20260410%WP5189%HOMO SAPIENS Copper metabolism SLC11A2 SLC31A1 ATP7B ATP7A COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260410%WP545%HOMO SAPIENS Complement activation MASP1 C1QB C1QA C1S C4A CFD C1R CFP C2 CD55 C1QC C6 C7 HEL-S-62p C4B_2 C9 C8G MASP2 C8A METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260410%WP5355%HOMO SAPIENS Metabolic epileptic disorders SQOR MOCS3 MPC2 CBS AASS FBP2 XDH PGAM1 SLC7A2 SPCS1 GLUD1 CTH ALDOB HK3 ETHE1 SUOX ENO2 ENO3 GCK HK2 MDH2 PC CDO1 SLC25A5 G6PC1 AADAT DLD GOT2 ACAT1 HEL-S-32 HEL-S-30 PSPH HEL-S-133P PFKP HEL60 SHMT1 SFXN1 SLC25A1 SLC2A3 ECHS1 MOCS2 PHGDH MOCS1 HEL-S-51e SLC2A4 GLDC AMT PSAT1 SLC2A2 ALDH7A1 HEL-S-20 PFKL MPC1 PCK1 DHTKD1 FBP1 SLC25A15 LDHB GLS2 DLAT ARG1 ASL GCDH HEL-S-87p PKLR ASS1 GPHN PGAM2 GPT OTC ENO1 BTD HEL-S-68p PDHA1 HLCS PFKM HEL-S-162eP HEL-S-49 HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260410%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells CSF2 KIR2DL1 KIR2DL3 TNF FYN NLRP7 NLRP2 SYK PRKCA TYROBP ELF3 LCP2 RAC1 PRKCQ PLCG1 LAT HLA-C IFNG PTPN6 VAV1 SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260410%WP4725%HOMO SAPIENS Sphingolipid metabolism overview PLPP2 CERK PLPP1 SGMS1 SPHK2 SPTLC1 SPHK1 SGMS2 GBA2 SGPP2 SGPP1 UGCG SPTLC2 SGPL1 SMPD1 DEGS2 KDSR UGT8 CERS6 CERS1 CERS2 CERS3 DEGS1 PLPP3 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260410%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates G6PC1 VHL SIRT7 MYC PGAM1 FOXO1 OTUB2 USP37 HEL-S-133P FBP1 USP44 USP28 USP19 KDR U2AF2 MTOR OTUD6B HIF1A HK2 OTUD7B HEL-S-68p VEGFA PIK3CA NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260410%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS2 PTGS1 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260410%WP5166%HOMO SAPIENS Glyoxylate metabolism DAO SLC26A1 PXMP2 GOT2 HAO1 HOGA1 AGXT PRODH2 HEL-S-133P HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260410%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 LAMA5 EDAR SNAI1 MYC NCAM1 TNLG7C INHBA CCND2 GTPBP4 ITGB1 FOXI3 RUNX2 NFKB1 LRP5 TP63 GJB6 PDGFA PDGFRA SHH CCND1 SMO FZD1 PTCH1 CTNNB1 LEF1 FGFR2 BMP4 IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260410%WP2007%HOMO SAPIENS Iron metabolism in placenta HEL60 TF STEAP3 TFRC SLC40A1 HEPHL1 SLC11A2 TFR2 MCOLN1 HAMP IREB2 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260410%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFATC3 CD8B1 NFATC1 NFATC2 STAT3 PTPN11 BATF CD8A CD3G CD3E CD3D IFNG HLA-A JUN PDCD1 PDCD1LG2 HLA-DRB1 ZAP70 NFAT5 NFKB1 NFATC4 LCK SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260410%WP2267%HOMO SAPIENS Synaptic vesicle pathway SYN1 AP2A1 AP2S1 SLC17A6 SLC17A7 CLTCL1 SLC22A3 CPLX2 CLN8 CPLX1 RIMS1 SLC17A8 AP2A2 SLC18A1 UNC13C SLC18A3 SYT1 SLC32A1 SYP SNAP25 SYN2 STX1B STX3A SLC18A2 DNM3 SLC38A1 AP2M1 NAPA STX1A SLC1A3 UNC13B CLTC HEL-S-67p UNC13A SLC25A4 STXBP1 VAMP2 CLTA STX2 CACNA1B CACNA1A HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260410%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming PIP4K2A CADM1 HDAC2 HDAC1 EP300 EZH2 TET2 IFITM3 ANKRD13C IRS1 NOL9 CREBBP GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260410%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells GNA15 PLCB3 DCT PLCB1 PLCB2 GPR143 POMC PMEL ARRB2 PRKCB TYRP1 MC1R PRKACG ADCY9 ASIP GNAS TYR CREB1 VEGFA PLCB4 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260410%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways PTEN PIK3C2G PIK3C2A PIK3C2B BAD PRKAA1 HMGCS1 PRKAB2 PRKAB1 HMGCR SREBF2 PIK3R3 NEUROD1 PIK3R5 PIK3CA PRKAG1 PRKAG2 SIN3A ABCG4 PI3 KIF5A RAB3GAP1 PRKAG3 SLC12A2 REST EGFR IKBKB TSC1 MAPK1 MBP HRAS CYP46A1 MAPK3 IL6 RHEB MAP2K4 MAP2K1 MAP2K2 NR1H2 MAPK10 DEPTOR RAF1 TSC2 PIK3CD RPTOR RPS6KA5 MLST8 CYP51A1 IL1B DHCR7 CREB1 PIK3R4 BDNF PIK3R2 PIK3R1 EIF4EBP1 MAP3K10 EIF4E SP1 BCL2L11 MTOR RPS6KB1 GABRB3 GABRB2 GABRB1 HDAC2 HDAC1 GABRE GABRQ C1QA GABRA2 PPARGC1A AHI-1 GABRP SLC12A5 GABRA6 GABRA5 AKT3 GABRA4 MAPK8 GABRA3 GABRG3 GABRG2 CASP8 GABRG1 CASP3 AKT1S1 PRKAA2 BCL2 HEL-S-29 APOE ABCA1 NTRK2 OPA1 EGF BNIP3 BAX BCL2L1 NFKB1 ABCG1 HTT MAPK9 RICTOR HAP1 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260410%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways ACSL3 ABCA1 ELOVL4 MYLIP ELOVL3 ACSL1 HMGCS1 NR1H3 FADS1 CYP46A1 SOAT1 HMGCR SOAT2 TM7SF2 SREBF2 HSD17B7 SCD FACL4 FASN NR1H2 CH25H GGPS1 ACAT2 ABCG1 FADS2 ELOVL5 ELOVL2 IDI1 CYP27A1 FDPS MVK CYP51A1 DHCR24 MSMO1 SQLE EBP PMVK SC5D MVD DHCR7 LBR FDFT1 SICKLE CELL DISEASE%WIKIPATHWAYS_20260410%WP5604%HOMO SAPIENS Sickle cell disease TLR4 HBA2 IL1B HBB IL18 FELBAMATE METABOLISM%WIKIPATHWAYS_20260410%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260410%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF3F EIF3D SUI1 EIF3CL EIF3A EIF1AX EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3E EIF3C EIF3S3 EIF3B EIF2S2 EIF2S1 CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260410%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling CRHR1 FOSB PLCG2 ARHA SP1 PLCG1 HSD3B1 ACACA TGFB1 GSK3B ECE1 GNB2 CASP9 GNAI1 GNB3 ARRB2 MAPK8 GNB5 CYP11A1 CRHBP CASP3 KRT1 PRKCQ IVL GNAO1 KRT14 GNB1 GNAS CRH NFKBIA CYP21A2 PARP1 TCF4 TLR4 PRKAA2 BCL2 CXCL8 POMC MAP3K5 MAPK1 FOS TRIM28 ERN1 MAPK3 STAR GNAZ SULT2A1 MAP2K1 BRAF NFKB1 MAPK14 RAF1 IL2 IL18 JUP CASP12 JUNB GJA1 PRKCB CRHR2 PRKCA TFAP2A CTNNB1 HSD3B2 PRKCI RELA MAPK9 CACNA1H CAMK2A JUND CREB1 GNA11 FOSL2 FOSL1 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260410%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ MAPK1 MAP3K14 CHUK MAP2K6 RAF1 NFKBIA IKBKB MAP3K1 IKBKG NFKB1 TRAF6 RRAS CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260410%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function MMP2 SCN10A MMP9 SCN8A BDNF MMP14 SLC2A3 AGER PRKCZ MMP21 NOS2 MMP20 MMP24 MMP27 MMP28 PRKD3 MMP10 MMP11 MMP16 MMP15 MMP17 MMP19 MMP25 MMP23B SNAP25 TRPA1 SORD PRKCH PRKCB TRPV1 PRKCE MMP3 PRKCA PRKCI PRKCQ SCN9A HEL-S-62p MMP12 MMP7 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260410%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia MCL1 BCL2 ZAP70 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260410%WP5195%HOMO SAPIENS Disorders in ketolysis BDH1 OXCT1 HMGCS1 ACAT2 ACAT1 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260410%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway PLPP2 CERK PLPP1 SGMS1 SPHK2 SPTLC1 SPHK1 SGMS2 SGPP2 SGPP1 UGCG SPTLC2 SGPL1 SMPD1 DEGS2 KDSR CERS5 UGT8 CERS6 CERS1 CERS2 CERS3 DEGS1 PLPP3 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260410%WP5360%HOMO SAPIENS KCNQ2 related epilepsies CHRM1 CALM1 AGTR1 KCNQ2 PPP1R10 PPP3CC BDKRB2 PLCG2 CSNK2A1 PRKCA STX1A P2RY1 KCNQ3 SCN1B AKAP5 BACE1 HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260410%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling PTEN MYC TCF3 INSR NFKBIE FGFR4 KDR STAT3 MTOR ZBTB16 REL FGFR1 FLT1 ULK2 FLT3 EPHA2 FLT4 PIK3CA IGF1R NGFR GSK3B CCND1 PML AKT3 TTI1 CHUK CDKN1A GAREM2 AKT1S1 NFKBIA APC KSR1 KIT MET EGFR FGFR3 FOXO1 IKBKB IKBKG NTRK1 NTRK2 TSC1 MAPK1 FOS HRAS MAPK3 AXIN2 IL6 RETN RHEB JUN MAP2K1 MDM2 MAP2K2 BRAF NFKB1 IL6R LRP5 LRP6 GRB2 KRAS SOS1 DEPTOR RAF1 SOS2 PDGFRA TSC2 RARA JUP NR1C2 PYGO1 PIK3CD WNT1 BCL9 SALL4 RPTOR CTNNB1 MLST8 SRC CSF1R RELA LEF1 FGFR2 CSNK1A1 RUNX1T1 MRNA PROCESSING%WIKIPATHWAYS_20260410%WP411%HOMO SAPIENS mRNA processing HNRNPK SRSF9 U2AF2 PRMT2 TMED10 YBX1 HNRPR POLR2A CLP1 PAPOLA TXNL4A PSKH1 PRP4K CDC40 PRPF4 PRPF6 PRPF3 SRSF4 SREK1 SRSF6 SRSF7 SNRPA DHX8 CSTF3 CSTF2 SFRS5 SFRS8 CSTF1 DHX38 SRPK2 PTBP1 CPSF4 CPSF1 PRPF40A CPSF3 CPSF2 DICER1 SFRS3 CLK4 LSM2 CLK1 LSM7 RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 HNRNPAB SUGP1 CELF2 CELF4 RBM5 RBM17 SNRPB2 SRSF10 PRPF18 NHP2L1 DNAJC8 RNMT CSTF2T U2AF1 PABPN1 TRA2B NUDT21 HNRNPA2B1 RBMX PRMT1 HNRNPH1 SPOP FUS SNRPD2 SNRPD1 SNRPD3 SNRPG SNRPE SNRPF SNRPB PRPF8 WDR57 METTL3 DHX16 SRPK1 NONO SNRPA1 SRP54 SF3B5 SF3B2 HNRNPD SF3A1 SF3A2 PHF5A DDX1 NCBP1 NCBP2 CELF1 DHX15 PPM1G SFPQ SMC1A SUPT5H CLK2 SF3B1 HNRNPL SNRPN MEVALONATE PATHWAY%WIKIPATHWAYS_20260410%WP3963%HOMO SAPIENS Mevalonate pathway MVK HMGCS1 ACAT2 HMGCR PMVK MVD FDPS HINT1 PATHWAY%WIKIPATHWAYS_20260410%WP5523%HOMO SAPIENS HINT1 pathway NFATC2 MNAT1 CCNH CDK7 GTF2H2C_2 RUVBL1 KARS1 SH3RF1 HINT1 RUVBL2 CTNNB1 FOS ERCC2 MAPK9 GTF2H2 JUN GTF2H3 GTF2H5 USF2 NFKB1 TCF4 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260410%WP5382%HOMO SAPIENS TGFB Smad signaling WWTR1 SMAD2 SMAD4 POSTN SPARC TGFBR1 TGFBR2 YWHAG TGFBR3 CTGF KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260410%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence TLR4 AHR TDO2 AADAT HAAO AFMID IDO2 TNF KLF5 KYNU FOXO1 IL1R2 EIF2AK1 EIF2AK4 KMO IFNB1 CDKN1A IFNG IDO1 HEL-S-90n AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260410%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways CLCN7 OSTM1 SNX10 TCIRG1 RAB7A TNFSF11 TNFRSF11A IKBKB PLEKHM1 NFKB1 TRAF6 RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260410%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 IL1A AGTR2 SERPING1 ROCK1 ACE2 AGTR1 TNF BDKRB2 NR1i1 ARHA BDKRB1 REN KNG1 CYP24A1 MAPK1 IL1B KLNA1 KLKB1 CPN1 NFKB1 CYP3A4 PRKG1 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling MMP2 TNFSF6 EGFR MCL1 ATF2 BCL2 FAS HBEGF BMF BAK1 MAP3K5 BCL2L11 FOS CDKN2A MAP2K6 IL6 MAP2K3 MAP2K4 CCNE1 BAX JUN BCL2L1 NFE2L2 TRAF5 MAPK14 TNFRSF1A TNFSF10 MAPK12 FGF7 RB1 IL2 TNF PDGFRA CCND1 JUNB MAPK8 MAPK11 TRAF2 CDKN1A CCNA2 IFNG MAPK13 TRAF6 TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260410%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 CDK6 EZH2 RBBP4 ARID1A CDK4 SUZ12 CDKN2A SMARCC2 SMARCE1 RB1 SMARCD1 DPF1 DPF3 SMARCC1 SMO SMARCD2 EED SMARCD3 ACTL6B PTCH1 ACTL6A GLI4 ARID1B GLI3 DPF2 SMARCA4 H3F3B EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260410%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation PRKAR1B PRKAR1A IL1B NLRP3 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome CCDC42 CDC27 ARHA TUBA2 STAT3 RAC1 AMER3 STMN2 MZT2A FAM168B CCDC74A POTEE GPR148 ARHGEF4 APC CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260410%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias CYP51A1 DHCR24 EBP SC5D DHCR7 LBR 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5408%HOMO SAPIENS 15q25 copy number variation BNC1 SHANK1 TENT4B SYNJ1 BTBD1 GOLGA6L4 ADAMTSL3 C15orf40 FSD2 AP3S1 WHAMM SEC11A NMB HOMER2 SPCS1 AP3B2 SPCS2 ALPK3 ZSCAN2 PDE8A SHANK3 EGF RYR1 WDR73 AP3D1 RNMT RAF1 SH3GL3 RYR2 DNM3 SPCS3 NMBR HTT AGAP2 TM6SF1 RAMAC ZNF592 EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260410%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway DOK1 CRK ATF2 PIK3R1 BCL2 SPAG1 CBL ARAF INPP5D NRAS EIF4B MAPK1 HRAS MAPK3 MAP3K2 SHC4 SHC2 SHC3 BRAF MAPK14 HSPB2-C11orf52 PIK3CA GRB2 RPS6KA1 BCR KRAS SOS1 RAF1 AKT3 BCL9 MAPK11 CRKL SRC MEF2C PXN BCLAF1 HEL-S-102 GAB2 VAV1 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260410%WP2855%HOMO SAPIENS Dopaminergic neurogenesis SOX2 PITX3 STAT3 EN2 LMX1A NKX6-1 LMX1B NEUROD1 SLC6A3 MSX1 NKX2-2 NEUROG2 OTX2 TGFB1 FOXA2 HEL-S-53e FGF8 SHH CDKN1C SLC18A2 WNT1 GBX2 EN1 ASCL1 DDC TH RET CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260410%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide TGFB1 CTLA4 CD80 FAS IL12A IFNG IL2 IL10 IL4 IL5 VIP OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260410%WP623%HOMO SAPIENS Oxidative phosphorylation ATP5PB ATP5F1D ATP5F1E ATP5PO NDUFB9 NDUFC2 ND3 NDUFC1 NDUFS6 ATP5J NDUFS5 ATP5H NDUFS4 NDUFS3 ATP5MG ND1 ATP5MF NDUFS1 ATP5ME DMAC2L ND2 ND5 ND4 ATP6AP2 ND6 NDUFB8 NDUFB7 NDUFA11 NDUFB10 NDUFB6 NDUFB5 COXFA4L2 NDUFB4 NDUFB2 NDUFB1 COXFA4 NDUFV3 NDUFV2 NDUFA7 NDUFA6 NDUFA3 NDUFA2 ND4L ATP5G1 NDUFA9 HEL-S-271 NDUFA5 NDUFAB1 NDUFS8 ATP6 ATP5MC2 ATP5MC3 NDUFA10 HEL-S-123m INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260410%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IL1A TLR4 SMAD2 STAT4 IL5 STAT1 IF2B1 IL13 IL23R IL18RAP STAT3 RORC IL6 IL-21 JUN TBX21 IL21R NFKB1 RORA GATA3 TGFB1 IL17F NFATC1 NOD2 FOXP3 HLA-DMA MAF IL2RG IL2 TNF IL4 IL18 IFNGR1 IL12A IFNG IL10 IL23A IL12RB1 TLR5 EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260410%WP3930%HOMO SAPIENS EDA signaling in hair follicle development EDAR BMP1 EDARADD TNLG7C SOSTDC1 DKK1 RELB SHH DKK4 WNT3 PTCH1 LTB ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260410%WP106%HOMO SAPIENS Alanine and aspartate metabolism ASL ABAT ASPA GOT2 ASS1 GAD2 GPT AGXT GAD1 PC 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5380%HOMO SAPIENS 5q35 copy number variation ADAM10 GPRIN1 MYC PIK3R1 BARD1 KDM6B RGS14 FBXW7 INPP5D HK3 FGFR4 PLCG1 PRR7 KIAA1191 FAF2 NELFB DDX41 TRIAP1 BABAM1 CAPN3 BABAM2 TMED9 RNF44 UNC5A MYO7B ARFGAP2 HIC2 IGF1R DOK3 CDHR2 TMED10 FAM193B DBN1 MAGED1 LMAN2 RAB24 ZNF346 SNCB GNAI3 PRELID1 PTPRN2 GNAI1 NOP16 EED MAPK8 MUPCDH ARL10 HIGD2A TSPAN17 ANKS4B MXD3 FGF8A FRS2 PDLIM7 CLTB GRIN2B PFN3 NTN1 EIF4E1B ABHD5 H2AX RNP24 COX6A1 SLC34A1 PNPLA2 COX6B1 HEL-S-273 UIMC1 CYP7A1 JUN GRIN1 USH1C COX7A1 COX3 ABRAXAS1 COX7B BRCC3 MAPK10 COX4I1 COX7C SNCA GRB2 PTH BRCA1 COX8A SOS1 COX5A DRD2 SRC MAX MAPK9 CXCR4 H3F3B COX2 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260410%WP4630%HOMO SAPIENS Measles virus infection CDK6 BBC3 ADAR IFIH1 BAD MAVS OAS1 RIGI CDK4 PIK3R3 HEL-S-72p PIK3CA CCND3 TP73 NFKBIB MX1 IKBKB IKBKG FOS CD3G CD3E IL6 CD3D CCNE1 JUN CDK2 MAPK10 IF1AA9 PIK3CD EIF2AK4 JAK1 IL1B IFNAR2 CD209 TYK2 RAB9A HEL70 IRF9 IFNAR1 PIK3R2 PIK3R1 IFNA13 CD46 IFNA14 IFNA16 IFNA17 CLEC4M EIF2AK2 OAS2 FCGR2B IFNA10 STAT1 STAT2 STAT3 IFNA21 NFKB2 IFNA1 IL2RG TRADD CCND1 CASP9 TNFAIP3 MAPK8 IL2RA IL2RB CASP8 TBK1 LNIR IRAK1 CASP3 IKBKE RCHY1 CHUK RAB9B IL12B IFNB1 IL12A FADD MAP3K7 IRAK4 NFKBIA TLR9 IRF3 EIF2S1 APAF1 TRAF3 TLR7 TRAF6 IRF7 IL1A TLR4 TNFSF6 MYD88 BCL2 HSPA2 IFNA4 FAS CYCS IFNA7 IFNA6 CCND2 IFNA2 IFNA8 BAK1 CSNK2A1 CSNK2A3 CSNK2A2 EIF3S3 BAX BCL2L1 NFKB1 CSNK2B CCNE2 IL2 CDKN1B JAK3 EIF2AK1 RELA MAPK9 STAT5B HEL-S-103 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260410%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome ESPL1 PTTG1 PLK1 CDC2 STAG2 SMC1B PTPA WAPAL RAD21 PDS5B PDS5A PPP2R1B SMC3 PPP2R5C SMC1A NIPBL AURKB PPP2R5E REC8 HDAC8 PPP2R5B PPP2R1A PPP2R5A CDCA5 SGOL1 ESCO1 ESCO2 PPP2R5D MAU2 STAG3 PPP2CA APC AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260410%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GATF-C GLYATL2 ACSS2 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260410%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development L1CAM ATF4 SCN2A KCNQ2 SNAP25 CSNK2A1 CSNK2A2 SEMA3A SCN5A SPTAN1 DDIT3 SPTBN4 BRSK1 PRRT2 ANK2 CSNK2B EIF2A NUCLEAR RECEPTORS%WIKIPATHWAYS_20260410%WP170%HOMO SAPIENS Nuclear receptors NR0B1 NR2A1 NR5A2 NR1I3 NR1B3 NR1i1 NR2F1 NR1i2 RORC NR1H3 NR1C1 RXRB RXRA RXRG NR1H2 NR1D2 RORA ROR1 NR3A2 NR3C1 ESRRA NR2F2 PPARG NR2F6 RARA NR1C2 NR5A1 PGR THRA RARB NR2C2 NR1A2 NR2E1 ESRRB CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260410%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation SHANK1 CASK HES5 HOMER3 PECAM1 AQP4 SOX2 LMX1B TPH1 GAD2 S100B SLC6A2 SLC6A3 NGFR FEV SYP SNAP25 NEF3 CNP CSPG4 NEFL BMP4 FGF7A 5HT1A CACNG2 SNAI1 ROBO1 MAP2 HOMER1 OLIG2 DPPA3 ZFP42 MBP DLG4 SHANK3 MOG SLC6A5 TPM1 GATA6 CDH2 CD34 GLS LHX1 NOTCH1 LEF1 NODAL NR2A1 AP2A1 TWIST2 PAX3 PAX6 MSX2 GAD1 HOMER2 ADRA2C HTR5A ADRA2B ADRA2A ITGB1 FOXD3 MSX1 MIXL1 FOXA2 SOX10 CLDN11 AP2A2 DLG2 NLGN1 PIG59 SLC1A2 SLC1A3 UNC13A ITGA6 TH POU5F1 GRIN2B DCX GFAP ESRRB RIMS2 SLC6A9 BSN RBFOX3 FBXO15 ACHE TBR1 LIN7A FUT4 CD24 SOX17 PCLO ERC1 DPPA2 ERAS GLRA1 GLRA2 GLRA3 GLRB TWIST1 RIMBP2 SLC17A6 SLC17A7 SNAI2 GRIN1 SLC6A1 GABBR1 SLC18A3 KLF4 GATA4 TBXT SOX9 ChAT HES3 GPHN TNC GABBR2 HES1 KCNJ6 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260410%WP5606%HOMO SAPIENS Beta globin gene expression regulation HDAC2 HBG2 MTA2 HDAC1 HBG1 HBB GATAD2B HBE1 HBD PPARGC1A KLF1 tal-1 LDB1 MYB KDM1A BCL11A LMO2 ZFPM1 ZBTB7A GATA1 NR2C2 CHD3 PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260410%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling MCL1 SLC2A3 PTGS2 BAK1 EDN1 NOS2 ANGPT2 ANGPT1 IGFBP2 BNIP3 BAX BCL2L1 BIRC5 PFKL EPO BCL2A1 PMAIP1 IGFBP1 HEL-S-30 HEL-S-133P HIF1AN BNIP3L HIF1A TGFA PDHA1 HEL-S-68p EGLN1 VEGFA CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP3869%HOMO SAPIENS Cannabinoid receptor signaling AHR DAGLA CNR1 ADCY1 CYP2C9 CYP2C19 CYP1A1 PRKACG MAPK1 PRKAR1B PRKAR1A CNR2 MAPK3 NAPEPLD DAGLB ADORA2A MAPK14 MAPK12 MAPK10 MAPK8 MAPK11 FAAH MAPK9 MAPK13 CYP3A4 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260410%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response IL1A CXCL8 TNF ITGA4 KNG1 VCAM1 SELP SELPLG IL6 C6 C7 ITGB1 HEL-S-62p LUNG FIBROSIS%WIKIPATHWAYS_20260410%WP3624%HOMO SAPIENS Lung fibrosis MMP2 ATP11A MMP9 CALCA IL5 PTX3 SFTPA1 CEBPB TERT TGFB1 BMP7 IGF1 TNF TIMP1 PDGFA SKIL SFTPC IL12B HGF TGFA CXCL2 CCR3 CCR2 CCL11 CXCL8 CMA1 CCL5 CCL4 CCL2 HMOX1 EDN1 IL13 CCL3 EGF IL6 FAM13A ELMOD2 GREM1 RTEL1 DPP9 FGF2 STN1 NFE2L2 SERPINA1 MUC5B CTGF CSF3 CSF2 FGF7 MT2A IL4 SPP1 KPG_011 IL1B SFTPA2 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260410%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients NEDD4 SMAD2 TGFBR1 TGFBR2 ATG16L1 TMEPAI ENERGY METABOLISM%WIKIPATHWAYS_20260410%WP1541%HOMO SAPIENS Energy metabolism PRKAA2 CAMK2G ATF2 EP300 NRF1 FOXO1 PPP3CC MED1 NCOA1 MEF2D PRKAA1 UCP2 FOXO3A NR1C1 PRKAB2 SIRT1 UCP3 PRKAB1 RXRA PPP3CA PPP3R1 TFAM MAPK14 HDAC1 ESRRA SIRT3 PPARG GSK3B PPARGC1A TFB2M TFB1M PPARGC1B PRKAG1 NR1C2 PPRC1 PRKAG2 CAMK4 PRKAG3 MEF2C GABPA PRMT1 MEF2B PPP3R2 MYBBP1A CREB1 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260410%WP167%HOMO SAPIENS Eicosanoid synthesis PLA2G5 PLA2G6 PTGES PRXL2B ALOX5 PTGS2 ALOX15 ALOX15B ALOX12 LTC4S ALOX5AP PLA2G4B PTGIS PTGS1 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260410%WP51%HOMO SAPIENS Regulation of actin cytoskeleton ACTN1 PIK3C2G PIK3C2A CHRM2 STM7 PIK3C2B NCKAP1 PIP4K2A PIP5K1A PIP4K2B PIP5K1C PIK3R3 PIK3R5 PIK3CA ARPC5 DOCK1 GNG12 RASSF7 GNA13 FGF8A TMSB4X FGF7B PFN1 FGF7A FGF18 ROCK2 EGFR FGFR3 WAS FGF21 FGF6B PAK6 NRAS RRAS MAPK1 PAK4 BAIAP2 CSK ARHGEF7 MAPK3 FGF5C MAP2K1 FGF2 MAP2K2 BRAF MOS MYLK FGF7 KRAS FGF8 MYL1 SOS1 RAF1 MYL3 SOS2 PDGFRA PIK3CD RAC1 F2 IQGAP1 VAV1 HEL-S-15 FGF20 ARHGEF4 HEL70 FGF23 CHRM3 CRK CHRM1 FGF22 CHRM4 PIK3R4 CHRM5 EZR PIK3R2 PIK3R1 ROCK1 F2R FGF14 CDC42 ARHA FGFR4 FGF13 MAPK4 CFL2 FGF12 FGF10 FGFR1 FGF16 PDGFA ACTG1 PAK1 ITGA1 PS1TP5BP1 APC LIMK1 RAC3 APC2 ARHGEF1 EGF RDX RRAS2 WASF1 MYH10 MAPK6 SSH2 SSH3 SSH1 BRK1 PIP5KL1 FGD1 WASF2 ABI2 CD14 FGF9 BDKRB2 BDKRB1 CYFIP2 PXN FGFR2 HEL114 ARHGAP35 SLC25A46 PATHWAY%WIKIPATHWAYS_20260410%WP5521%HOMO SAPIENS SLC25A46 pathway APOOL MMGT1 IMMT TMEM85 COX4NB MICOS10 APOO MICOS13 CHCHD3 CHCHD6 EMC1 EMC2 EMC3 OPA1 EMC6 EMC7 MFN1 EMC10 MFN2 ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260410%WP5124%HOMO SAPIENS Alzheimer 39 s disease ADAM10 PSEN2 CSNK1A1L APH1B VDAC3 PSENEN ATP2A1 DDIT3 ULK2 ULK1 PPIF PLCB4 PIK3CA SLC25A5 CACNA1F PLCB1 PLCB2 CACNA1S RTN4 KIF5A HEL-S-61 ATP2A2 TUBA1A PTGS2 IKBKB MAP3K5 NOS2 ERN1 APP IL6 RYR3 PPP3CA LRP5 LRP6 ATF4 CSF1 PSEN1 IL1B GPR83 BACE1 NAE1 MCU RB1CC1 WIPI1 CYBB TRAF2 ATG2A CHUK ADAM17 GRIN2B EIF2S1 APOE NOX4 CDK5R1 GRIN1 SHFM1 RELA MAPK9 BAD PPP3CC CHRNA7 PIK3R3 ITPR2 SLC25A4 PPP3R2 NRBF2 ATG2B IDE TUBA1C MME TUBB LPL TUBB2A KNS2 PSMA8 TUBA3E TUBB4B TUBB4A TUBB8 TUBB6 TUBB1 AMBRA1 ATG14 TUBA4A HSD17B10 RTN3 CACNA1C ARAF KLC4 NRAS KLC3 KLC2 TUBA2 TUBA8 MAPK1 SLC25A6 HRAS TUBAL3 BECN2 MAPK3 ADRM1 SLC25A31 MAP2K1 MAP2K2 BRAF MAPK10 CALM1 PLCB3 CDK5 KRAS RAF1 IRS1 PIK3CD HEL-S-162eP PSMD12 HEL-S-276 HEL-S-91n PIK3R4 PSMD13 PIK3R2 PIK3R1 PSMB6 AGER PSMD9 PSMD6 INS PSMD7 EIF2AK2 PSMB2 PSMD4 INSR PSMB3 PSMD2 PSMD3 PSMD1 MTOR PPP3R1 PSMC6 PSMA4 PSMC4 PSMA2 PSMC1 GSK3B TNF AKT3 CASP9 MAPK8 CALML6 CASP8 CALML3 CALML4 CASP3 FADD WNT3A AXIN1 DKK4 APAF1 APC IL1A WNT2B FZD10 FAS FRAT1 CYCS FRAT2 IRS4 TUBA1B APC2 WNT5B CSNK2A1 CSNK2A3 CSNK2A2 XBP1 CSNK1E AXIN2 WNT16 DKK1 DKK2 SFRP4 NFKB1 CSNK2B TNFRSF1A SNCA ATG101 DVL1 WIPI2 DVL2 CASP12 DVL3 WNT1 WNT3 FZD1 CTNNB1 WNT10B WNT10A FZD3 FZD2 FZD5 CSNK1A1 WNT4 WNT7B FZD7 FZD9 WNT7A FZD8 IL26 SIGNALING%WIKIPATHWAYS_20260410%WP5347%HOMO SAPIENS IL26 signaling MMP9 IF2G MPO SMAD2 CXCL8 SOCS3 DEFB4B STAT1 MAPK1 STAT3 RORC EPHA3 MAPK3 ATP6V0D2 IL6 IL10RB BAX JUN DDIT3 IL33 CCL20 MAPK14 PIK3CA NFATC1 IL17A CSF2 CTSK ACTA2 DCSTAMP TNFSF11 TNF MAPK8 IL20RA CASP3 JAK1 IL1B RELA MAPK9 TYK2 IL10 NFKBIA COX2 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260410%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer NQO1 SQSTM1 TNFRSF21 YBX3 SOCS3 APOE ERBB3 F2R CTNNA1 GCLC MAPK1 HEL113 RNF7 ERN1 RPS6KB1 APP TNFRSF10B THBS1 PKN1 TRAF1 HEL-S-7 NFKB1 BIRC5 HDAC1 TNF CDKN1B HEL-S-89n NRG1 IL7R CUL5 HELLS BEX3 CDKN1A NET1 PTK2B AXIN1 CARD14 HEL-S-102 HSPD1 VAV3 JUND RIPK2 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260410%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders GLS2 HEL-S-20 ARG1 ASL NAGS F10 ASS1 F7 GPT OTC EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260410%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria H3C15 HDAC2 MTA2 HDAC1 HEL25 MBD2 RB1 RBBP4 RBBP7 KDM1A SUV39H1 CHD4 MBD3 LEF1 MTA3 CBX3 CBX1 H3C8 H3F3B CHD3 DNA REPLICATION%WIKIPATHWAYS_20260410%WP466%HOMO SAPIENS DNA replication PRIM2 POLA2 RPA3 MCM3 RPA1 PCNA MCM5 MCM6 UBC ORC6 CDC6 ORC3 ORC2 DBF4 CDK2 MCM2 PRIM1 ORC1L CDC45 POLD3 POLD4 POLD2 POLE CDT1 POLA1 RFC3 RFC4 MCM7 RFC1 MCM10 RFC2 RPA4 GMNN POLE2 MAPK SIGNALING%WIKIPATHWAYS_20260410%WP382%HOMO SAPIENS MAPK signaling DUSP9 DUSP7 RAPGEF2 TAOK3 CACNB4 CACNA1G RASGRF2 DUSP16 PPM1B CACNG6 CACNG7 RPS6KA3 TAOK1 CACNG3 CACNG4 CACNG5 pk MAP3K8 DDIT3 HEL-S-72p CACNB1 CACNA1F CACNG1 CACNA1S FGF8A STK4 MAP4K1 MAP4K2 FGF7B CACNG8 MAPK13 FGF7A CACNG2 FGF18 FGFR3 ATF2 FGF6B NTF4 NTF3 IKBKB IKBKG MAP3K5 MAP4K3 FOS FGF5C PPP3CA FGF2 ATF4 FGF7 FGF8 MAP3K6 MEF2C IL1B MAX FGF20 MAPK8IP2 FGF23 MAP2K5 FGF22 BDNF DUSP4 DUSP2 FGF14 FGFR4 FGF13 FGF12 MAP3K11 PTPN5 FGF10 FGFR1 HEL-S-31 NFATC1 MAPKAPK5 IL1R2 CACNA2D1 TRAF2 NGF CHUK MAP3K7IP1 TRAF6 NFATC3 PPP5C HSPA2 MAPK7 NTRK1 NTRK2 EGF CD14 PRKCA RELA MAPK9 PLA2G4F JUND DUSP3 PLA2G4D PLA2G4E PLA2G4C MYC PPP3CC CDC25B PRKACG RASGRF1 GNG12 FLNA FLNB MAPK8IP1 PPP3R2 DUSP10 EGFR FGF21 CACNA1C ARAF NRAS NF1 RRAS MAPK1 HRAS MAP2K6 MAPK3 MAP3K2 MAP2K3 MAP2K4 JUN MAP2K1 MAP3K1 MAP2K2 BRAF MAPK14 MAPK12 MAPK10 GRB2 KRAS SOS1 RAF1 LAMTOR3 SOS2 MAP3K12 CRKL RPS6KA4 RPS6KA5 RAC1 CACNB3 CACNA1B CACNA1A CRK RAP1A CDC42 RASA2 NFKB2 PPP3R1 FGF16 ECSIT TGFB1 IL1R1 MAP3K14 PDGFA TNF AKT3 ARRB2 MAPK8 PAK1 CACNA1I CASP3 MAP3K7 RELB HEL-S-102 TGFBR1 TGFBR2 IL1A TNFSF6 MAPKAPK3 GADD45A MAPKAPK2 FAS SMIM40 LRRK2 RAC3 TAOK2 MAP3K13 RRAS2 NFKB1 TNFRSF1A RASGRP4 NLK RASGRP3 MAPK11 FGF9 PLA2G4B FGFR2 CACNA1H CACNA2D3 CACNA2D2 CACNA2D4 HEL-S-103 MAPK8IP3 DUSP8 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260410%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis PLA2G4B PLA2G5 PLA2G6 ACOX3 FADS1 ACSL3 FACL4 FADS2 ELOVL5 ACSL1 ELOVL2 ACOX1 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260410%WP5314%HOMO SAPIENS Lactate shuttle in glial cells HEL-76 LDHB SLC4A4 CA4 SLC16A3 SLC1A2 SLC2A3 SLC16A7 HEL-S-133P NUDT14 TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260410%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling TGIF2 SMAD2 FGF8 FOXG1 GLI3 NODAL SHH NKX2-1 TGIF1 WNT SIGNALING NETPATH%WIKIPATHWAYS_20260410%WP363%HOMO SAPIENS Wnt signaling NetPath CDK6 NFATC2 TCF3 STM7 FRAT1 CSNK1G1 ARHA MAPK1 TSC1 MTOR CSNK1E LRP5 ROR1 LRP6 GCKR ROR2 CTBP1 NLK PPARG PI4K2A GSK3B SOX1 DVL1 CCND1 DVL2 TSC2 DVL3 ARRB2 MAPK8 BCL9 PRKCB PRKCA CTNNB1 TCF7L2 RAC1 CSNK1D LEF1 MAPK9 MAP3K7 CSNK1A1 AXIN1 RYK GSK3A APC TCF4 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260410%WP4315%HOMO SAPIENS Malate aspartate shuttle GOT2 SLC1A3 SLC25A11 HEL-S-32 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260410%WP3958%HOMO SAPIENS GPR40 role in insulin secretion FFAR1 PLCB3 PLCL1 PLCD3 PLCE1 PLCB1 PKD1 PLCB2 PLCG1 PLCH1 GNA11 PLCG2 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260410%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition MTOR RPS6KB1 SLC2A4 RPS6 TBC1D4 IRS1 INSR ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260410%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism CYP1B1 UGT1A10 CYP2C9 CYP2C8 HSD17B10 CYP2C19 CYP3A7 UGT1A8 HSD17B1 HSD17B2 SULT1E1 UGT2A2 HSD17B3 HSD17B4 UGT2B7 HSD17B7 CYP3A4 INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260410%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases NTRK2 BDNF SNCA APP CEBPB SET AKT3 SRPK2 BACE1 TARDBP STAT1 ID SIGNALING%WIKIPATHWAYS_20260410%WP53%HOMO SAPIENS ID signaling RBL1 RB1 MYOD1 ID3 ID1 RBL2 ID2 PAX5 ELK3 PAX8 CCNE1 CDK2 PAX2 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260410%WP5049%HOMO SAPIENS Glycolysis in senescence PRKAA1 RB1 ENO1 HEL-S-68p HEL-S-162eP HEL-S-30 HEL-S-133P TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260410%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma PTEN GRB2 KRAS SOS1 RAF1 SOS2 TSC2 JAK3 AKT3 NRAS RPTOR STAT3 TSC1 EREG MTOR HRAS JAK1 EGF RHEB TYK2 BTC TGFA BREAST CANCER PATHWAY%WIKIPATHWAYS_20260410%WP4262%HOMO SAPIENS Breast cancer pathway CDK6 HES5 PTEN MYC CSNK1A1L CDK4 CETN3 SHC4 SHC2 SHC3 PIK3R3 PIK3CA IGF1R IGF1 FGF8A CDKN1A FGF7B FGF7A KIT FGF18 EGFR FGF21 FGF6B ARAF NRAS MAPK1 FOS HRAS MAPK3 FGF5C JUN MAP2K1 FGF2 MAP2K2 BRAF LRP5 LRP6 GRB2 FGF7 KRAS FGF8 TNFSF11 SOS1 RAF1 JAG2 SOS2 PIK3CD PGR HEY2 NOTCH1 DDB2 LEF1 FGF20 FGF23 FGF22 PIK3R2 PIK3R1 NOTCH2 NOTCH3 SP1 MTOR RPS6KB1 NFKB2 FGF10 FGFR1 FGF16 FLT4 RB1 E2F2 GSK3B E2F3 CCND1 AKT3 RAD51 WNT3A SKP1 AXIN1 PARP1 APC ERBB2 GADD45B GADD45A WNT2B GADD45G FZD10 FRAT1 FRAT2 BRCA2 NCOA1 BAK1 APC2 WNT5B CSNK2A1 CSNK2A3 ATR CSNK2A2 AXIN2 EGF WNT16 BAX RPS6KB2 SFRP4 CSNK2B NR3A2 RAD50 MRE11A ATM BRCA1 NBN DVL1 DVL2 DVL3 WNT1 FGF9 WNT3 FZD1 POLK CTNNB1 WNT10B TCF7L2 WNT10A FZD3 TCF7L1 FZD2 FZD5 WNT4 CSNK1A1 WNT7B FZD7 FZD9 DLL3 DLL4 WNT7A FZD8 HES1 MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260410%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer KSR1 MYC KRAS SOS1 RAF1 SOS2 FOS MAPK3 GAREM2 ALK JUN MAP2K1 MAP2K2 BRAF FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260410%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism HADHB NR1C1 ESRRA SLC2A4 ACADM MTTP APOB PPARGC1B ACLY STK11 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260410%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway IL1A MYD88 MYC MAPKAPK2 ATF2 IKBKB EIF4E MAPK1 MAP3K8 MBP FOS MAP2K6 SAFB MAPK3 MAP2K3 MAP2K4 MAP2K1 MAP3K1 MAP2K2 NFKB1 MAPK14 IRAK2 MAPK10 IL1R1 MAP3K14 TAB3 MAPK8 MAPK11 NFKBIB RPS6KA5 IRAK1 CHUK RELA MAPK9 MAP3K7 IRAK4 NFKBIA MAP3K7IP1 TRAF6 TANK IRF7 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260410%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 MR1 TNFRSF11A TLR3 IFIH1 MAVS TLR8 IRF3 RIGI TLR7 IRF7 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260410%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence ELAVL1 SIRT5 SIRT2 GOT2 SIRT3 HEL-S-32 PRKAA1 HMGA1 NAMPT SIRT1 IL1B SLC2A4 RELA IL6 MDH2 NMNAT2 PARP1 CCL27 G13 SIGNALING%WIKIPATHWAYS_20260410%WP524%HOMO SAPIENS G13 signaling ROCK2 WAS PIK3R2 ROCK1 CDC42 LIMK1 ARHA PIP4K2A ARHGEF1 CFL2 RPS6KB1 RTKN RHPN2 MYBPH PKN1 CYFIP1 PIK3CA HEL-S-80p MAPK10 CALM1 MYL1 ARHGDIG PIK3CD SH3RF1 GNA13 WASL RAC1 ARHGDIB IQGAP1 HEL-S-15 CIT PFN1 TNK2 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260410%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis HES7 EPHA4 RIPPLY2 TBX6 FGF8 NOTCH1 WNT3A MESP2 LFNG HES1 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260410%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome GOLGA8H CHRFAM7A CCL5 FYN KAT2B FAN1 MTMR10 GOLGA8R CHRNA7 FANCD2 ARHGAP11B GRM6 KLF13 GPR75 OTUD7A GOLGA8O CREBBP GOLGA8Q TRPM1 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260410%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways HEL-S-14 CAMK2G HEL2 CRHR1 PLCG2 PRKAR1B PRKAR1A ADCY9 PLCG1 ADM ATF6B ITPR2 GRK5 GRK4 CRCP RXFP2 IGFBP4 CNN2 CALD1 GNG12 IGFBP6 GNG11 PDE4D GNG13 RAMP2 RYR2 RAMP3 GNB2 CORIN IGFBP1 GNB4 ADCY3 GUCA2B GNB3 GUCA2A GNB5 ACKR5 GNG2 YWHAZ GNGT1 GABPA GNB1 GNAS PRKD1 ATP2A2 YWHAQ ATF2 ADCY1 ADCY8 ADCY6 GNG3 GNG5 GNG4 GNG7 GNG8 FOS IL6 RYR3 JUN MAFF RYR1 CALM1 PLCB3 ATF4 ACTA2 MYL4 MYL2 GABPB1 SLC8A1 RGS4 GJA1 RGS5 RGS1 IL1B CREB3 RGS6 RGS7 CACNB3 CREB1 PKIB PKIA PKIG CALCA PRKCZ RGS18 IGFBP5 RGS17 RGS14 RGS16 RGS20 SP1 DGKZ RGS11 PDE4B RGS10 ATF5 OXTR HEL-S-1 ACTG1 OXT ARRB2 RGS2 PS1TP5BP1 PRKCQ CRH RAMP1 LPAR1 ACTA1 SFN YWHAG ACKR3 IGFBP2 NFKB1 ETS2 ATF3 PRKCH PRKCB PRKCE PRKCA HEL-S-21 MYLK2 CAMK2D CAMK2A RLN1 ATF1 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260410%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ACSL3 ELOVL3 FADS2 ELOVL5 ACSL1 ELOVL2 ELOVL1 SCD5 ELOVL6 FADS1 SCD FACL4 FASN OXYTOCIN SIGNALING%WIKIPATHWAYS_20260410%WP2889%HOMO SAPIENS Oxytocin signaling OXTR COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260410%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260410%WP2881%HOMO SAPIENS Estrogen receptor pathway GPAM SP1 PDK4 STAT3 CYP1B1 NR1C1 JUN NR0B2 PCK1 ACOX1 CYP1A1 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260410%WP5461%HOMO SAPIENS Primary ovarian insufficiency BLM ATG9A MST1R PPM1B FANCM FANCL MSH4 STRA8 FMR1 DAZL CENPE POLR3H PRORP ANTXR1 MEIOSIN POF1B FANCC MEIOB MCM9 SIL1 NANOS3 GNAS PREPL EIF2B5 NOBOX AARS2 AIRE HMMR WDR62 SYCE1 SOHLH1 KASH5 SOHLH2 SWI5 COX10 HELQ DIAPH2 H1-8 HROB LHX8 MCMDC2 ELAVL2 BMPR2 C1orf146 MRPS22 SIX6OS1 HAX1 ZAR1 CCDC185 MGME1 C10orf2 MND1 NLRP11 XPNPEP2 SPATA33 CLPP POLR2C LARS2 POLG BMP6 FIGLA DMC1 PCCA PCCB ERAL1 BNC1 NOTCH2 HSD17B1 KHDRBS1 HSD17B4 CYP17A1 TP63 LAMC1 PRDM1 DCAF17 RAD51 BMP15 WRN GDF9 FSHR LMNA STAG3 TGFBR3 BRCA2 ZP3 STAR EIF4ENIF1 NR3A2 SLX4 RECQL4 AMHR2 ATM PGRMC1 NBN EIF2B1 FANCA FOXL2 ALOX12 NR5A1 SALL4 RFWD3 NUP107 WT1 SOX8 AMH PSMC3IP EIF2B2 BMPR1A EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260410%WP581%HOMO SAPIENS EPO receptor signaling GRB2 EPOR SOS1 EPO RAF1 SOCS1 IRS1 STAT1 STAT3 MAPK1 SRC PTPRC MAPK3 PTPRU CISH MAP2K1 STAT5B MAP2K2 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260410%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy ACTN1 CACNB4 CACNG6 CACNG7 CACNG3 CACNG4 CACNG5 DSC2 ITGB5 ITGB1 SGCA ITGB4 ITGB8 PKP2 ITGB7 CACNB1 ITGB6 ITGA7 CACNA1F CACNG1 CACNA1S RYR2 ACTG1 ITGAV ITGA4 ITGA2 ITGA1 PS1TP5BP1 CACNA2D1 LMNA ITGA6 ATP2A2 CACNG8 CACNG2 SGCD SGCB CTNNA1 SGCG CACNA1C CTNNA3 CTNNA2 EMD DMD ACTN2 ACTN4 ITGB3 CDH2 ITGA2B JUP SLC8A1 tmp_locus_29 GJA1 DAG1 CTNNB1 TCF7L2 TCF7L1 LEF1 CACNB3 CACNA2D3 DSG2 CACNA2D2 CACNA2D4 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260410%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer MMP9 CXCL8 CCL5 CXCL12 CCL2 IL5 REG4 IL13 LGALS9 IL25 VEGFB IL6 VEGFC VEGFD CCL20 CCL28 CXCL1 TGFB1 IL17F IL17A CSF2 IL17D CXCL5 IL17C IL17B IL2 TNF IL4 IL1B IL12B IL12A IFNG IL10 IL23A VEGFA IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260410%WP5172%HOMO SAPIENS Iron metabolism disorders TF STEAP3 TFRC SLC40A1 FTH1 PANK2 SLC11A2 HAMP CP FTL UQCRFS1 CYBRD1 HFE2 HEPH TFR2 HFE HIPPO YAP SIGNALING%WIKIPATHWAYS_20260410%WP4537%HOMO SAPIENS Hippo YAP signaling STK38L WWTR1 YAP1 RASSF1 NF2 MAP4K3 TNIK LATS1 TEAD2 LATS2 TEAD3 TEAD4 MAP4K1 MAP4K2 MINK1 HEL-S-31 SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260410%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis CPLX1 RPH3A RIMS1 SYT1 SYP SNAP25 STX1B NAPA UNC13A STXBP1 VAMP2 STXBP5 STXBP6 CACNA1B GDI1 CACNA1A GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260410%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism ST8SIA1 SIAT4C NEU3 B3GALT4 ST8SIA5 ST3GAL1 NEU4 ST8SIA6 B4GALNT1 HEXB ST3GAL5 HEXA ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260410%WP3878%HOMO SAPIENS ATM signaling in development and disease CHEK2 ATF2 PPP5C RNF168 CHEK1 IKBKG ATR TRIM28 MTOR CDK2 ATMIN RIF1 NFKB1 CEP63 STK11 MAPK14 MDC1 RNF8 MAPK12 RAD50 PPM1D CDK5 MRE11A ATM RBBP8 NBN PRKDC TP53BP1 SMC1A HMGN1 LMNB2 TSC2 MAPK11 AURKB NHEJ1 KAT5 HEL-S-102 PPP2CA MAPK13 DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260410%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades PLG SERPING1 MASP1 CD46 F2R HEL-S-78p C1S CFH C1R CFI KNG1 F9 PROC F10 PROS1 F13B C4B_2 VWF C1QB C1QA THBD C1QC CLTC CR2 LMAN1 CFD C2 PLAUR CD55 SERPINA1 CPB2 SERPINC1 TFPI APOA2 PLAT BDKRB1 SERPINF2 F2 F3 F5 F7 C6 F8 C7 HEL-S-62p CLU C9 KLKB1 C8G C5AR1 C3AR1 MASP2 CR1 SERPIND1 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260410%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling TGFB1 SMAD2 BMPR2 MAPK8 LOX BMP1 SMAD4 MAPK9 GREM1 TGFBR1 TGFBR2 LOXL2 MAPK14 LOXL1 LOXL4 BMPR1A CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260410%WP1604%HOMO SAPIENS Codeine and morphine metabolism ABCC3 UGT1A3 ABCC2 ABCB1 UGT1A1 UGT1A10 UGT1A9 CYP2C8 SLCO1B1 UGT1A8 UGT2B4 UGT2B7 CYP3A4 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260410%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX11 COX10 COX6A1 COX6B1 COXFA4 COX7A2 COX3 COX17 COX19 COX7B COX16 COX18 COX4I1 TACO1 COX7C HIGD1A COX14 COA6 COX8A CSRP2BP PET100 FAM36A CMC1 COX5A TMEM177 PNKD SMIM20 COA3 SURF1 COX2 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260410%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways PTEN FGF8A HNF1A ACTR2 FGF7B BMP4 FGF7A FGF18 EGFR FGFR3 FGF21 FGF6B BMPR2 ARAF MAPK1 FOS HRAS MAP2K6 FGF5C MAP2K3 JUN MAP2K1 MDM2 FGF2 MAP2K2 BRAF LRP5 MAPK12 LRP6 GRB2 FGF7 FGF8 SOS1 RAF1 PDGFRA FZD4 PIK3CD JAK1 WNT9B SELENOP FGF20 FGF23 MAP2K5 FGF22 ACVR1 SMAD6 PIK3R2 FGF14 ACVR2B FGFR4 FGF13 MAPK4 STAT3 FGF12 PTPN11 MTOR SMAD1 FGF10 FGFR1 FGF16 SMAD9 DKFZp781O1323 GSK3B PDGFA AKT3 SMAD4 WNT3A AXIN1 LIF APC WNT2B MAPK7 ERAS WNT5B EGF WNT16 MAPK6 NOG DVL1 DVL2 DVL3 WNT1 FGF9 WNT3 FZD1 CTNNB1 WNT10B IL6ST WNT10A FZD3 FZD2 FZD5 FGFR2 WNT4 WNT7B FZD7 FZD9 WNT7A FZD8 BMPR1A MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260410%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth CDKN1B HMBOX1 HIPK1 HIPK2 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260410%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH3A2 ALDH2 ACO2 ALDH9A1 ACSS2 CS 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5400%HOMO SAPIENS 6q16 copy number variation LEP BDNF NPY INS INSR POMC SIM1 NTRK2 MC4R GHSR AgRP GHRL LEPR 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260410%WP5407%HOMO SAPIENS 15q11q13 copy number variation MLSN2 SLF2 CGN CXNO FAN1 GOLGA8R CHRNA7 KLF13 OTUD7A GOLGA8O GOLGA8Q TRPM1 GOLGA8H HDAC1 CANX STX1B ANKRD2 SIN3A TJP1 CCL5 APP FANCD2 CREBBP CDC42BPB CALM1 CXADR TJP3 GJA1 SPEF1 SMC5 KAT2B SMC6 STX1A ANKRD32 GOLGA8T MTMR10 NSMCE3 NSMCE2 RELA NSMCE1 GOLGA8K STXBP1 GOLGA8J GJD3 MYZAP NECAB3 LYPD6 ENTREP2 UBN1 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260410%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS BMP2 OLIG1 OLIG2 MBP MOG FGF2 NKX2-2 CXCL1 SOX10 SOX6 IGF1 TNF SOX5 SHH OMG CNTF SOX8 SOX9 IL1B CNP ASCL1 CXCL2 LIF NKX2-6 MYT1 BMP4 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260410%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects ERBB4 PRL KLF2 CXCL12 RGS16 MYB OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260410%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy VHL ACAN COL2A1 CNMD P4HTM FGFR3 GANC FOSB NTRK1 FGFR4 KDR MAPK1 STAT3 FOS COL1A1 MAPK3 COL3A1 FGFR1 CEBPB JUN RUNX2 NFKB1 CTGF PIK3CA IBSP COL10A1 SPP1 LAMTOR1 DDR2 AKT3 JUNB PRKCA SOX9 NGF HIF1A RELA FGFR2 RELB JUND VEGFA FGF23 FOSL2 FOSL1 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260410%WP4830%HOMO SAPIENS GDNF RET signaling axis AGTR2 ROBO2 SOX17 ROBO1 SOX11 IFT27 SPRY1 GREM1 FAT4 SLIT2 PAX2 GATA3 IFT25 FOXC2 WT1 HOXD11 CTNNB1 HOXA11 SALL1 LHX1 GLI3 SIX2 GDNF ALDH1A2 EYA1 TCF2 FOXC1 HOXC11 RET BMP4 RAS SIGNALING%WIKIPATHWAYS_20260410%WP4223%HOMO SAPIENS Ras signaling PLA2G4C PLA2G3 PLA2G5 PLA2G6 PLA2G10 RASGRF2 BAD RASSF1 PLCG2 PRKACG KDR PLCE1 TIAM1 PLCG1 RAPGEF5 SHC4 SHC2 SHC3 RASGRF1 PIK3R3 EPHA2 GNG10 PIK3CA IGF1R RAB5C NGFR GNG12 GNG11 GNG13 GNB2 GNB4 GNB3 GNB5 GNG2 GNGT1 STK4 GNGT2 GNB1 KSR2 KIT EGFR FGFR3 PLA2G2A GNG3 IKBKB GNG5 PAK6 SYNGAP1 IKBKG GNG4 NF1 NRAS RRAS GNG7 MAPK1 GNG8 PAK4 EXOC2 ABL2 HRAS MAPK3 MAP2K1 MAP2K2 SHOC2 MAPK10 CALM1 RASA3 GRB2 RAB5B KRAS SOS1 RAF1 SOS2 PDGFRA PIK3CD RAC1 RIN1 CSF1R GAB2 ZAP70 RAB5A PIK3R2 PIK3R1 RASAL1 FOXO4 RASAL3 TTBK1 RAP1A RASA4B PLAAT3 CDC42 RASA4 ARF6 INSR PLA2G2F PLA2G2E PLA2G2C ARHA FGFR4 RASA2 PTPN11 REL FGFR1 FLT1 FLT3 FLT4 AKT3 MAPK8 PAK1 CALML6 CALML3 CALML4 CHUK LAT GRIN2B PLA1A KSR1 TNFSF6 MET AFDN RAC3 NTRK1 NTRK2 GRIN1 HTR7 BCL2L1 NFKB1 RRAS2 ETS2 RALBP1 RASGRP4 PLD2 RASGRP3 PRKCB PRKCA PLA2G4B RELA FGFR2 MAPK9 RALA PLA2G2D PLA2G12A RALB PLA2G4F PLA2G12B PLA2G4D PLA2G1B PLA2G4E CORI CYCLE%WIKIPATHWAYS_20260410%WP1946%HOMO SAPIENS Cori cycle SLC2A4 HEL-S-87p GPT INS PGAM1 HEL-S-68p HEL-S-162eP SLC2A2 HEL-S-49 HEL-S-133P PFKP DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260410%WP707%HOMO SAPIENS DNA damage response BBC3 CDK6 CHEK2 MYC TLK1 CDC2 CDK4 TNFRSF10B TP53AIP1 SESN1 CCND3 RB1 PRKDC CCNB2 CCND1 PML CASP9 RAD51 CASP8 CASP3 CDKN1A APAF1 RRM2B GADD45B GADD45A GADD45G FAS CYCS CCND2 SFN CHEK1 H2AX RAD1 ATRIP HUS1B ATR TLK2 RAD9A CCNB3 CCNE1 BAX FANCD2 CDK2 MDM2 RAD50 CCNE2 CDK5 MRE11A ATM BRCA1 NBN PMAIP1 SMC1A CDKN1B RAD52 RAD17 PIDD1 RFC1 CCNB1 DDB2 CREB1 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260410%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CHRNA3 CACNA1G CACNA1C CHRNB4 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260410%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260410%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment TNFSF6 FAS NRP1 CCL5 CXCL12 BAG3 CCL2 CXCR3 KDR CTLA4 HLA-DRA HLA-DRB1 ITGB6 IFITM2 TGFB1 CSF2 CSF2RA CSF1 CD80 CCR5 CSF1R CXCR4 CCR2 LAG3 VEGFA TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260410%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias SMAD6 SMAD2 INHBA STAT1 ADAMTSL2 RUNX3 pp6425 STAT3 SMAD1 ZFYVE9 BAMBI ITGB6 SMAD9 TGFB1 DKFZp781O1323 FKBP1A ZNF423 TNF SKIL SMAD4 TGFBR1 TGFBR2 LIF TGFBR3 BMP4 EP300 SKI LEFTY1 LEFTY2 FOS HRAS MAPK3 EGF THBS1 RUNX2 JUN FOXH1 NFKB1 CREBBP NOG FST SPP1 WNT1 TGIF1 CTNNB1 ZEB2 JAK1 IFNG LEF1 MAPK9 LTBP1 FBN1 ENG VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260410%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression CHRM1 ATP2B1 BCL2 KCNQ2 KDM6B CACNA1C GCLC CYP27B1 NR1i1 ATP2B3 KDM1B ATP2B2 CALB1 ATP2B4 TPH2 PVALB TPH1 RXRA GRIN1 ITPR2 NFE2L2 SLC8A1 KDM1A CYP27A1 KDM3A HEL-75 KCNQ3 GRIN2B WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260410%WP399%HOMO SAPIENS Wnt signaling and pluripotency MYC PRKCZ SOX2 ARHA FBXW2 PPM1J FOXD3 CCND3 PPP2R1B PPP2R5C GSK3B CCND1 PPP2R5E PPP2R1A PRKCQ WNT3A PPP2R3A MAP3K7 AXIN1 PPP2R2C PPP2R2B CTNND1 POU5F1 PRKD1 PPP2CA NFYA ESRRB APC ZBTB33 WNT2B EP300 CD44 FZD10 FRAT1 LRRK2 CCND2 LDLR WNT5B PAFAH1B1 CSNK1E AXIN2 WNT16 MAP2K4 JUN PTPA CREBBP LRP5 LRP6 MAPK10 CTBP2 CTBP1 NLK NKD1 NKD2 DVL1 DVL2 NR1C2 DVL3 FZD4 PRKCH WNT1 PPP2R2A PRKCB WNT3 PRKCE FZD1 PRKCA CTNNB1 WNT10B PPP2R3B PRKCI TCF7L2 WNT10A WNT9B FZD3 TCF7L1 FZD2 LEF1 MAPK9 FZD5 WNT4 WNT7B FZD7 FZD9 WNT7A FZD8 MMP7 FOSL1 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260410%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis SLC2A3 MPC2 FBP2 PGAM1 ALDOB HK3 ENO2 ENO3 GCK SLC2A4 HK2 MDH2 SLC2A2 PC G6PC1 PFKL GOT2 DLD HEL-S-32 MPC1 PCK1 HEL-S-30 HEL-S-133P FBP1 PFKP LDHB DLAT HEL-S-87p PKLR PGAM2 ENO1 PDHA1 HEL-S-68p PFKM HEL-S-162eP HEL-S-49 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260410%WP3407%HOMO SAPIENS FTO obesity variant mechanism UCP1 PRDM16 IRX3 PPARGC1A IRX5 TBX1 ARID5B