4 HYDROXYTAMOXIFEN DEXAMETHASONE AND RETINOIC ACIDS REGULATION OF P27 EXPRESSION%WIKIPATHWAYS_20260810%WP3879%HOMO SAPIENS 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression MAP2K3 MAP2K1 PRKAA1 MAP2K2 PIK3CD PIK3R3 TSC2 TSC1 PIK3R2 PIK3R1 HEL164 MTOR EIF4EBP1 MAPK1 RAF1 EIF4E MAP3K11 MAP2K6 MAP3K5 MAPK3 TESSADORI BICKNELL VAN HAAFTEN SYNDROME VARIANTS NUCLEOSOME ASSEMBLY%WIKIPATHWAYS_20260810%WP5573%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome variants nucleosome assembly RBBP4 HIST1H4L SMIM40 H2BC12 HIRA CHAF1B H4C9 CHAF1A INHIBITION OF GNAQ REGULATED SIGNALING IN UVEAL MELANOMA%WIKIPATHWAYS_20260810%WP5490%HOMO SAPIENS Inhibition of GNAQ regulated signaling in uveal melanoma PIK3CD PIK3R3 TSC2 TSC1 PIK3R2 PIK3R1 MTOR MAPK1 YAP1 TRIO ROCK1 PKN3 AKT3 TEAD2 TEAD3 TEAD4 LATS1 MOB1A PLCB3 PLCB4 LATS2 ARHA PKN2 PKN1 PLCB1 PLCB2 METABOLIC PATHWAY OF LDL HDL AND TG INCLUDING DISEASES%WIKIPATHWAYS_20260810%WP4522%HOMO SAPIENS Metabolic pathway of LDL HDL and TG including diseases APOB LDLR ABCA1 SCARB1 ANXA2 MTTP APOA2 PCSK9 LPL LIPC APOC2 LIPG APOE GABA RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP4159%HOMO SAPIENS GABA receptor signaling GABRB3 GABRB2 GABRB1 ABAT AP2A1 AP2A2 GPHN AP2S1 GABRE AP2M1 GABRQ GABRA2 GABRP GABBR2 GABBR1 GABRA6 SLC32A1 GABRA5 GAD1 GABRA4 GABRA3 GAD2 SLC6A11 GABRG3 GABRG1 ALDH9A1 MIRNA TARGETS IN ECM AND MEMBRANE RECEPTORS%WIKIPATHWAYS_20260810%WP2911%HOMO SAPIENS miRNA targets in ECM and membrane receptors XB LAMC1 THBS2 THBS1 COL3A1 COL1A2 COL4A2 COL4A1 COL5A3 COL6A1 COL5A2 ITGB6 LAMB2 LAMA4 SDC2 ITGA1 ETHANOL EFFECTS ON HISTONE MODIFICATIONS%WIKIPATHWAYS_20260810%WP3996%HOMO SAPIENS Ethanol effects on histone modifications ALDH1A3 KAT2B ALDH1A2 HAT1 CYP2E1 HDAC5 ATF2 HDAC2 ACSS2 HDAC3 HDAC10 ADH1C HDAC1 HEL-S-117 ADH1A MTR TYMS HDAC8 HDAC7 ALDH2 HEL-S-53e SLC19A1 ELP3 MAT1A DHFR NETRIN UNC5B SIGNALING%WIKIPATHWAYS_20260810%WP4747%HOMO SAPIENS Netrin UNC5B signaling ROBO4 SRC ITGB4 AGAP2 MAP2K1 NTN1 RLF MAP2K2 TNF NTN3 CTGF PTPA PPP2R1B CASP3 INPP5D KDR PTK2B MAPK1 CCL2 FYN RAF1 RAC1 PLEKHH1 IL10 JUN MAPK3 ARHGEF12 VCAM1 UNC5B PRKCA PTPN11 CIP2A MAPK14 SELE RGMA YAP1 COL1A1 IL1A DCSTAMP ALPL MYF5 ARHA CARDIAC HYPERTROPHIC RESPONSE%WIKIPATHWAYS_20260810%WP2795%HOMO SAPIENS Cardiac hypertrophic response IGF1 NFKB1 TGFBR1 TNFRSF1A CDK9 CDK7 PRKD1 MAP2K3 CALM1 MAP2K1 MAP3K14 FGFR2 MAP2K2 TNF MTOR MAPK1 RAF1 RAC1 MAP2K6 MAPK3 PRKCA MAPK14 GSK3B CAMK2D GUCA1A FGF2 HDAC5 IKBKB PPP3CA MAPK8 MAPK7 NPPA IKBKG IKBKE MAP3K7 PRKG1 MAP2K5 MAP4K1 MAP2K4 TGFB1 HDAC7 MAP3K1 CHUK EGF PDPK1 PLA2G2A NFATC2 NRG1 IL19 SIGNALING%WIKIPATHWAYS_20260810%WP5422%HOMO SAPIENS IL19 signaling MAPK14 NFKB1 TNFRSF1A COL1A1 CCL11 STAT1 TNF STAT3 IL20RA CXCR4 MAPK8 IL19 IL20RB MUC5AC ACTA2 IL4 CCNB1 MAPK1 SOCS1 RAC1 SOCS5 JAK1 TGFB1 MAPK3 GLYCEROLIPIDS AND GLYCEROPHOSPHOLIPIDS%WIKIPATHWAYS_20260810%WP4722%HOMO SAPIENS Glycerolipids and glycerophospholipids PISD AGPAT4 PTDSS2 PTDSS1 GPAM GPAT4 PNPLA3 PEMT CHPT1 CDIPT PNPLA2 CDS1 DGAT2 PCYT2 CHKB DGAT1 PLA2G1B CRLS1 DGKZ PHASE I BIOTRANSFORMATIONS NON P450%WIKIPATHWAYS_20260810%WP136%HOMO SAPIENS Phase I biotransformations non P450 LIPA CES2 CES1 PON3 PON2 ESD PON1 HEL126 RUBINSTEIN TAYBI SYNDROME 1%WIKIPATHWAYS_20260810%WP5367%HOMO SAPIENS Rubinstein Taybi syndrome 1 FBL CREBBP SMAD4 PCNA CREB1 MAFG IRF2 HEL23 DDX21 NPAS2 FOXO1 GLYCOSYLATION AND RELATED CONGENITAL DEFECTS%WIKIPATHWAYS_20260810%WP4521%HOMO SAPIENS Glycosylation and related congenital defects ALG9 B4GALT1 ALG6 TUSC3 SRD5A3 ALG2 ALG14 ALG13 ALG3 DOLK ALG12 ALG1 ALG11 MAGT1 DPM1 GMPPB DPM2 DPM3 MGAT2 GCS1 MPDU1 DPAGT1 ALG8 PLURIPOTENT STEM CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260810%WP2848%HOMO SAPIENS Pluripotent stem cell differentiation pathway IGF1 ALK CSF1R CNTF WNT2B NOTCH1 CSF1 EPO PDGFA INS FGF4 NTF4 NT5E SHH TPO FGF8 CXCR1 TNFSF11 WNT1 IL6R IL11 LEFTY1 WNT3A FGF2 HGF WNT7B FST NOG FLT3LG INHBA DKK1 GDF5 VEGFA BMP4 IL3 IL6 KITLG TGFB1 TF KIT NODAL EGF FGF10 REGULATION OF TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP1449%HOMO SAPIENS Regulation of toll like receptor signaling NFKB1 STAT1 SOCS1 MAP2K3 MAP2K1 MAP2K2 PIK3CD PIK3R3 PIK3R2 PIK3R1 MAPK1 MAP2K6 MAPK3 AKT3 IL6 OTUD5 CD80 TBK1 IL12B IL12A MAP3K8 IFNAR2 IFNA13 IFNA14 TICAM2 FBXW5 CISH IFNA16 IFNA17 CD180 TRAFD1 TICAM1 RNF41 SIGIRR BTK RBCK1 SQSTM1 IFNAR1 IFNA10 LY96 PIK3R5 IRAK1 IRAK2 RIPK1 CD14 FADD IFNA21 PLK1 SMAD6 NFKB2 NFKBIA CYLD CXCL11 TAB3 MYD88 IFNA5 IFNA4 IFNA7 CD40 CUEDC2 CXCL9 CXCL8 IFNA6 IFNA1 IFNA2 TNFAIP3 IFNA8 TREM1 CASP8 MLST8 LBP TMED7 MBL2 SYK SFTPD IRAK3 IRAK4 FOS opn TIRAP TLR1 IRF3 TRAF3 IL1B TRAF6 PELI1 TLR9 IRF7 TLR8 TLR7 TLR5 ZMYND11 TLR4 TLR3 TNF RNF31 SFTPA2 PELI3 RELA MAPK9 CCL5 TIFA CCL4 CCL3 IFNB1 MAPK12 RAC1 MAPK13 MAPK10 MAP3K7IP1 JUN MAPK11 SARM1 PTPN6 MAPK14 IKBKB MAPK8 IKBKG IKBKE MAP3K7 MAP2K4 CHUK BIOSYNTHESIS AND REGENERATION OF TETRAHYDROBIOPTERIN AND CATABOLISM OF PHENYLALANINE%WIKIPATHWAYS_20260810%WP4156%HOMO SAPIENS Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine MAOA PAH ASMT JDP1 DBH PTS PNMT AANAT SPR DHFR TH BUTYRATE INDUCED HISTONE ACETYLATION%WIKIPATHWAYS_20260810%WP2366%HOMO SAPIENS Butyrate induced histone acetylation ACLY PROGERIA ASSOCIATED LIPODYSTROPHY%WIKIPATHWAYS_20260810%WP5103%HOMO SAPIENS Progeria associated lipodystrophy SMAD2 KCNJ6 ICMT PARP1 MUCL3 RECQL LMNB2 ZMPSTE24 WRN FNTA LMNA SPRTN FFAR3 PPARG SMAD4 BANF1 FBN1 TGFB1 INS METABOLIC REPROGRAMMING IN PANCREATIC CANCER%WIKIPATHWAYS_20260810%WP5220%HOMO SAPIENS Metabolic reprogramming in pancreatic cancer GNPNAT1 DLAT LDLR SLC16A4 PDHX PDHA1 GFPT1 GOT2 HEL-S-133P RPIA CS SLC7A5 GLUD1 PFKL SOAT1 CARM1 FASN DLD BCAT2 ACLY HEL-S-32 GLS2 RPE HEL-S-30 GPT HMGCR HK2 ME1 PGM3 EFFECT OF INTESTINAL MICROBIOME ON ANTICOAGULANT RESPONSE OF VITAMIN K ANTAGONISTS%WIKIPATHWAYS_20260810%WP5273%HOMO SAPIENS Effect of intestinal microbiome on anticoagulant response of vitamin K antagonists CYP2C9 NR1i1 NPC1L1 NR1i2 SCARB1 NR1C1 CD36 NR1C2 OSTEOBLAST SIGNALING%WIKIPATHWAYS_20260810%WP322%HOMO SAPIENS Osteoblast signaling PTH1R FGF23 SLC17A2 COL1A1 TNFSF11 PDGFRA IBSP BGLAP PTH ITGB3 ITGAV TNFRSF11B LNCRNA LIKE NMRK2 IN TRANSLOCATION RENAL CELL CARCINOMA%WIKIPATHWAYS_20260810%WP5519%HOMO SAPIENS LncRNA like NMRK2 in translocation renal cell carcinoma FH MDH2 NMRK2 NONO SLC19A2 CS THYROXINE THYROID HORMONE PRODUCTION%WIKIPATHWAYS_20260810%WP1981%HOMO SAPIENS Thyroxine thyroid hormone production NFKB1 TPO MAP2K1 PRKAA2 PRKAA1 TRH MAP2K2 TSHR SLC5A5 DUOX1 CLCN5 TG RAP1A CGA HEL-S-5 DUOX2 MAPK1 RAF1 CREB1 MAPK3 PRKCA RESISTIN AS A REGULATOR OF INFLAMMATION%WIKIPATHWAYS_20260810%WP4481%HOMO SAPIENS Resistin as a regulator of inflammation IL12A NFKB1 PIK3CD TNF RELA MAPK1 MAPK3 NFKBIA MAPK14 AKT3 CXCL8 IKBKB PLCB3 PLCB4 IKBKG RETN PLCB1 PLCG2 PLCB2 PLCE1 PLCG1 IL6 PLCD3 PLCD4 CHUK IL12B NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN NOD PATHWAY%WIKIPATHWAYS_20260810%WP1433%HOMO SAPIENS Nucleotide binding oligomerization domain NOD pathway CASP5 IL1B NLRP7 NLRP2 NLRP3 NLRP1 AAMP RIPK2 CARD8 CARD9 ERBIN CARD6 IL18 NLRP12 COPS6 RELA ACAP1 AIM2 NLRP10 NAIP RAC1 NFKBIA IKBKB CASP8 IKBKG DUOX2 NDUFA13 NOD1 CHUK NOD2 NLRC4 MEFV CASP9 PYCARD 1Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4905%HOMO SAPIENS 1q21 1 copy number variation syndrome GJA1 GJA3 ACP6 GJA5 GJA8 AMELX TJP3 PRKAA2 PRKAA1 PRKAB2 PRKAG1 PRKAG2 NBPF12 CHD1L F11R PRKAB1 FMO5 PRKAG3 PYGO1 TJP1 PYGO2 AFDN BCL9 HEPATITIS B INFECTION%WIKIPATHWAYS_20260810%WP4666%HOMO SAPIENS Hepatitis B infection NFKB1 TGFBR1 STAT1 STAT3 JAK1 CREBBP SMAD4 PCNA CREB1 CASP9 MAP2K3 MAP2K1 MAP2K2 PIK3CD PIK3R3 PIK3R2 PIK3R1 MAPK1 RAF1 MAP2K6 MAPK3 ARAF AKT3 CREB3L3 CREB3L4 MYC CREB3L2 EP300 PRKCB HSPG2 VDAC3 ATF4 HEL-S-93 STAT5B EGR2 NFATC3 NFATC1 BRAF IL6 NFATC4 MAVS TNFSF6 BCL2 CYCS GRB2 RIGI TBK1 CDKN1A DDX3X IFIH1 CASP12 YWHAQ IFNA13 CASP10 IFNA14 HEL-S-1 TICAM2 JAK3 HRAS APAF1 IFNA16 TYK2 IFNA17 MMP9 DDB2 TGFBR2 TICAM1 DDB1 CREB3 BIRC5 SOS1 SOS2 CREB5 IFNAR1 ATF6B IFNA10 NRAS STAT4 BAD IRAK1 STAT2 BAX FADD IFNA21 MYD88 IFNA5 IFNA4 IFNA7 CXCL8 IFNA6 IFNA1 ATF2 IFNA2 IFNA8 CASP8 IRAK4 FOS TIRAP IRF3 TRAF3 TRAF6 IRF7 SRC TLR4 TLR3 TNF RELA MAPK9 CASP3 PTK2B IFNB1 MAPK12 MAPK13 MAPK10 MAP3K7IP1 JUN MAPK11 PRKCA MAPK14 SMAD2 IKBKB MAPK8 IKBKG IKBKE MAP3K7 MAP2K4 TGFB1 MAP3K1 CHUK NFATC2 LACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260810%WP5303%HOMO SAPIENS Lacto series sphingolipid metabolism hCG_1998026 B3GALT2 B3GNT5 B3GALT1 FUT1 FUT3 BENZO A PYRENE METABOLISM%WIKIPATHWAYS_20260810%WP696%HOMO SAPIENS Benzo a pyrene metabolism EPHX1 CYP1A1 CYP1B1 AKR1C2 AKR1C4 CYP3A4 HEL-S-165mP AKR1C1 RESOLVIN E1 AND RESOLVIN D1 SIGNALING DECREASE INFLAMMATION%WIKIPATHWAYS_20260810%WP5191%HOMO SAPIENS Resolvin E1 and resolvin D1 signaling decrease inflammation MTOR GRK1 FPR2 EPHB2 LTB4R CMKLR1 PIK3CD GLYCEROPHOSPHOLIPID BIOSYNTHETIC PATHWAY%WIKIPATHWAYS_20260810%WP2533%HOMO SAPIENS Glycerophospholipid biosynthetic pathway PIK3CD PCYT2 CHKB CRLS1 PTDSS1 GPAM GPAT4 PEMT CHPT1 CDIPT MOGAT3 PGS1 HMFN0839 PTPMT1 PIP5K1A GPAT2 CEPT1 IPMK GNPAT GPD1 LPIN1 LPIN2 PI4K2A CDS2 PLA2G2A NCRNAS INVOLVED IN STAT3 SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260810%WP4337%HOMO SAPIENS ncRNAs involved in STAT3 signaling in hepatocellular carcinoma NFKB1 JAK3 IL6 IL6R JAK1 IL11 IL11RA IL6ST SOX4 STAT3 RELA ECTODERM DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2858%HOMO SAPIENS Ectoderm differentiation ELOVL2 PAX3 SORCS1 BAZ1A FOXL1 SERPINB6 CLDN11 TOX3 ARHGAP10 FGFR2 KIFC3 NLGN1 RUTBC3 STX16 RRBP1 DMD CTNNA2 TBL1X CLVS1 CAP2 SNCA H2BC9 TTC14 TCF7L1 TNLG7C NR1C2 C1GALT1 PTPN13 VAX2 RIT1 GLB1 ZNF219 SPRY2 TNFRSF11B BCOR PDE7A MYORG FOXA2 SMAD4 PRKAG2 SHH WNT1 MYC BMP4 NFATC1 HDAC10 CTNND2 ARHGDIG CELSR2 CDH8 SOX2 CDH6 PIM1 KRT6A CDON KCNK10 TLE5 ROR2 MZF1 ASTN1 LY6E CTBP1 ARX GATA6 STC1 NLK ARHGAP15 ZBTB2 SOCS2 TRPM2 SDCBP CCL2 PLXNA2 FYN RHPN1 ST8SIA4 HESX1 ZBTB7B GAS2L1 SKIL TFAP2A TFAP2C FZD5 JUP SMURF1 FZD4 ZBTB16 RGMA GREB1 FZD8 NR2F2 POU2F2 ZFHX4 PAN2 PTPRB PPFIBP2 MAFB LHX1 MKS1 NF2 TCF3 OGT BMPR1A NUMA1 SCHIP1 HMGB2 FHL2 LDB2 GLI3 WDR44 SIX6 AHI-1 BOC UBTF RAB8B BCAS3 ELOVL4 ESTRADIOL REGULATION IN PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260810%WP5235%HOMO SAPIENS Estradiol regulation in porto sinusoidal vascular disease SP1 SP3 KCNN3 CALM1 MAMMARY GLAND DEVELOPMENT PREGNANCY AND LACTATION STAGE 3 OF 4%WIKIPATHWAYS_20260810%WP2817%HOMO SAPIENS Mammary gland development pregnancy and lactation stage 3 of 4 ELF5 ORAI1 PGR HDGFL2 BCL2L1 EIF4G1 EIF4E TNFSF11 CEBPA CEBPB PRL CSN2 TNFRSF11A MYC NR3C1 EGFR YY1 CCND1 ERBB3 ERBB4 ERBB2 DLGAP4 STAT5B PTPN1 TPM3 TFPI2 PRLR USF2 USF1 CLDN6 CHUK TTC9 NR3A2 GJB2 GAL NFIA NRG1 NFIB PHOTODYNAMIC THERAPY INDUCED UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260810%WP3613%HOMO SAPIENS Photodynamic therapy induced unfolded protein response PPP1R15A XBP1 EDEM1 UBE2E1 ASNS HEL-S-99n HEL-S-125m BBC3 HEL-S-89n DNAJC3 ERN1 ATF4 BCL2L11 SULT1E1 NARS1 DDIT3 DNAJB11 DNAJB9 ERP27 TRIB3 ATF3 EIF2A NFE2L2 GABA METABOLISM AKA GHB %WIKIPATHWAYS_20260810%WP4157%HOMO SAPIENS GABA metabolism aka GHB GAD1 ABAT GAD2 GLS2 PON3 HEL-S-166mP ALDH5A1 ADHFE1 GLS TRANSLATION INHIBITORS IN CHRONICALLY ACTIVATED PDGFRA CELLS%WIKIPATHWAYS_20260810%WP4566%HOMO SAPIENS Translation inhibitors in chronically activated PDGFRA cells PIM1 EIF4G1 MAP2K3 MAP2K1 MAP2K2 PIK3R3 PIK3R2 MAPK9 PIK3R1 MTOR EIF4EBP1 MAPK1 EIF4E MAPK10 MAP2K6 MAPK3 PRKCA EIF4A2 MAPK14 EIF4A1 RPTOR RPS6KA4 RPS6KA5 RPS6KA2 RPS6KA1 AKT3 PIM2 EIF4B CSNK2A1 RPS6 RPS6KB1 RPS6KB2 MAPK8 MAP2K5 MAP2K4 NAD METABOLISM%WIKIPATHWAYS_20260810%WP3644%HOMO SAPIENS NAD metabolism NT5E PARP1 NRK SIRT4 SIRT5 NMNAT3 SIRT6 NMNAT2 SIRT7 SIRT1 SIRT2 SIRT3 NMNAT1 NAMPT NADK GASTRIC CANCER NETWORK 1%WIKIPATHWAYS_20260810%WP2361%HOMO SAPIENS Gastric cancer network 1 HCTP4 LIN9 GATD3 AURKA KIF15 SMOC2 CENPF ESM1 APC RUVBL1 S100P CEP192 MYBL2 ECT2 KIF20B E2F7 NOTCH1 TOP2A INO80D NUP107 H3F3B H4C9 UBE2C ACTL6A PHOSPHOINOSITIDES METABOLISM%WIKIPATHWAYS_20260810%WP4971%HOMO SAPIENS Phosphoinositides metabolism PIK3CD MTMR1 MTMR10 INPP5D MTMR2 MTMR3 MTMR12 MTMR11 MTMR8 PTEN PIK3R4 MTMR9 PIK3C2G MTMR4 STM7 MTMR6 MTM1 PIK3C2B PIP4P2 PIP4P1 PIP4K2A PIP4K2B PIP5K1C SBF1 SBF2 SACM1L OCRL PIKFYVE PLCH1 PLCH2 PLCB3 PLCB4 PIP5K1A PLCB1 PLCG2 PLCB2 PLCE1 PLCG1 PLCD3 PLCD4 SEROTONIN RECEPTOR 4 6 7 AND NR3C SIGNALING%WIKIPATHWAYS_20260810%WP734%HOMO SAPIENS Serotonin receptor 4 6 7 and NR3C signaling RPS6KA5 MAP2K1 MAP2K2 NR3C1 ATF1 EGR1 HTR4 HTR6 RAP1A HTR7 MAPKAPK2 GNAS MAPK1 BRAF CREB1 MAPK3 CLASSICAL PATHWAY OF STEROIDOGENESIS WITH GLUCOCORTICOID AND MINERALOCORTICOID METABOLISM%WIKIPATHWAYS_20260810%WP4523%HOMO SAPIENS Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism H6PD HSD3B2 SRD5A2 HSD3B1 HSD17B3 CYP17A1 HSD11B1 HSD11B2 POR STAR CYP11B2 CYP21A2 CYP11A1 DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260810%WP707%HOMO SAPIENS DNA damage response APAF1 DDB2 CCNB1 BAX CCND1 CASP8 CREB1 CASP9 RB1 H2AX CDKN1B HUS1B TP53AIP1 PIDD1 CCND3 CCND2 CHEK2 SESN1 CHEK1 TLK2 TLK1 BBC3 NBN RFC1 SMC1A CASP3 CCNE2 RRM2B FANCD2 CCNE1 PRKDC CCNB3 CCNB2 PMAIP1 SFN ATRIP GADD45B GADD45A MRE11A TNFRSF10B PML CDC2 GADD45G RAD52 RAD50 CDK6 RAD51 CDK5 CDK4 CDK2 MDM2 RAD17 MYC RAD1 ATM RAD9A ATR CYCS CDKN1A COVID 19 AND ENDOTHELIAL CELL SENESCENCE%WIKIPATHWAYS_20260810%WP5256%HOMO SAPIENS COVID 19 and endothelial cell senescence IL17RA TLR4 IL17RC IL17A EICOSANOID METABOLISM VIA CYTOCHROME P450 MONOOXYGENASES PATHWAY%WIKIPATHWAYS_20260810%WP4720%HOMO SAPIENS Eicosanoid metabolism via cytochrome P450 monooxygenases pathway EPHX2 CYP4F2 CYP4A11 CYP4A22 PPARG CYP2C18 NR1C1 CYP4F12 GLYCOSYLPHOSPHATIDYL INOSITOL ANCHOR PATHWAY%WIKIPATHWAYS_20260810%WP5505%HOMO SAPIENS Glycosylphosphatidyl inositol anchor pathway PIGP PIGW PIGV PIGY PIGX PIGC PIGB PIGA PIGK PIGM MPPE1 PIGL PIGF PIGH DPM2 PIGS PIGU PIGT PGAP1 PIGO PGAP2 PIGN GPAA1 PGAP3 DIRECT REVERSAL REPAIR%WIKIPATHWAYS_20260810%WP4931%HOMO SAPIENS Direct reversal repair ALKBH3 ALKBH2 16P12 2 COPY NUMBER VARIATION SYNDROME 520KB %WIKIPATHWAYS_20260810%WP5510%HOMO SAPIENS 16p12 2 copy number variation syndrome 520kb CALM1 COX7C CYB EEF2K UQCRFS1 RAB5IF MOSMO NDUFS8 UQCRC1 NDUFS3 COXFA4 UQCRC2 CDH18 UQCRB UQCR11 UQCR10 COX5A UQCRH TRPM7 CYC1 PDZD9 CDR2 NDUFA9 SDR42E2 VWA3A PRKAA2 EEF2 UQCRQ POLR3E MLST8 MAP2K1 PRKAA1 MAP2K2 PRKAB2 MTOR PRKAG1 PRKAG2 MAPK1 MAPK12 MAPK13 PRKAB1 MAPK11 PRKAG3 MAPK3 CDC2 MAPK14 RPTOR RPS6KA1 CDK2 RPS6KB1 PHOTODYNAMIC THERAPY INDUCED NF KB SURVIVAL SIGNALING%WIKIPATHWAYS_20260810%WP3617%HOMO SAPIENS Photodynamic therapy induced NF kB survival signaling IL1B NFKB1 TRAF6 TNFRSF1A MMP9 TNF RELA BIRC5 VCAM1 NFKB2 SELE IL1A CXCL8 CSF2 BCL2A1 IKBKB PTGS2 CXCL2 CCND1 RELB EGLN2 MMP2 MMP3 IL2 VEGFA CD40LG REL IL6 BCL2L2 BIRC2 BIRC3 CHUK TYROSINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260810%WP4506%HOMO SAPIENS Tyrosine metabolism and related disorders GSTZ1 HPD OSTEOCLAST SIGNALING%WIKIPATHWAYS_20260810%WP12%HOMO SAPIENS Osteoclast signaling ACP5 TNFSF11 TNFRSF11A MAPK8 IFNAR1 IFNB1 ATP6V1G1 opn GPR68 ITGB3 AIMP2 CTSK TNFRSF11B TRPV5 FAMILIAL HYPERLIPIDEMIA TYPE 5%WIKIPATHWAYS_20260810%WP5112%HOMO SAPIENS Familial hyperlipidemia type 5 SEL1L LDLR APOA4 PLTP APOA5 GPIHBP1 LMF1 APOA2 LPL LIPC APOC2 FOLLICLE STIMULATING HORMONE FSH SIGNALING%WIKIPATHWAYS_20260810%WP2035%HOMO SAPIENS Follicle stimulating hormone FSH signaling MAPK14 SRC FSHB H3-4 RHEB RPS6 FSHR RPS6KB1 SGK1 RPS6KB2 APPL1 TSC2 CGA MTOR EIF4EBP1 MAPK1 RAF1 CREB1 MAPK3 PRKCA FOXO1 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY WITH INHIBITORS%WIKIPATHWAYS_20260810%WP4189%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway with inhibitors HMGCR MVD SEBALEIC ACID FORMATION AND METABOLISM%WIKIPATHWAYS_20260810%WP5315%HOMO SAPIENS Sebaleic acid formation and metabolism ALOX5 CYP4F3 FADS1 FADS2 ACSL1 VITAMIN D METABOLISM%WIKIPATHWAYS_20260810%WP1531%HOMO SAPIENS Vitamin D metabolism CYP27A1 NR1i1 RXRB CYP27B1 CYP24A1 RXRA CYP2R1 DHCR7 GC PTH S1P RECEPTOR SIGNAL TRANSDUCTION%WIKIPATHWAYS_20260810%WP26%HOMO SAPIENS S1P receptor signal transduction S1PR1 S1PR3 S1PR2 MAPK6 S1PR5 MAPK4 AKT3 PLCB3 MAPK7 PLCB1 MAPK1 PLCB2 MAPK12 MAPK3 SPHK2 SPHK1 GNAI3 GNAI1 PIK3C2B SMPD2 FAMILIAL HYPERLIPIDEMIA TYPE 1%WIKIPATHWAYS_20260810%WP5108%HOMO SAPIENS Familial hyperlipidemia type 1 SEL1L LDLR APOA4 PLTP APOA5 GPIHBP1 LMF1 ANGPTL8 ANGPTL3 ANGPTL4 APOA2 LPL LIPC APOC2 WNT SIGNALING AND PLURIPOTENCY%WIKIPATHWAYS_20260810%WP399%HOMO SAPIENS Wnt signaling and pluripotency PAFAH1B1 CTBP2 LDLR LEF1 LRP5 PPM1J PRKCZ PRKD1 NKD1 LRP6 NKD2 APC PPP2CA DVL1 DVL2 DVL3 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A FZD3 FZD2 NFYA TCF7L1 FZD7 ESRRB NR1C2 FZD9 WNT7A PPP2R3B PPP2R3A FOSL1 PPP2R2C PPP2R2B CCND1 CREBBP SOX2 CCND3 CCND2 CTBP1 PTPA PPP2R1B NLK MAPK9 MAPK10 WNT2B JUN PRKCA FZD5 FZD4 FZD8 WNT1 GSK3B LRRK2 CTNND1 MYC WNT3A PPP2R2A FZD10 EP300 WNT7B hCG_2014051 PRKCB FRAT1 PPP2R5E PPP2R1A ARHA FOXD3 PRKCI MAP3K7 MMP7 PRKCH WNT5B PRKCE MAP2K4 AXIN1 WNT9B AXIN2 ZBTB33 PPP2R5C WNT16 POU5F1 PRKCQ CD44 MACROPHAGE STIMULATING PROTEIN MSP SIGNALING%WIKIPATHWAYS_20260810%WP5353%HOMO SAPIENS Macrophage stimulating protein MSP signaling NFKB1 HEL-S-133P MMP9 FZD1 WNT10B ACTA2 SOCS1 PTEN PDGFRA IBSP BGLAP SMAD6 ITGB1 CSF3 FLT1 HEL113 SIX1 CXCL1 CLDN1 CXCL5 IGF1R COL4A1 CRKL PRKAA2 CDH2 CXCL8 DKFZp781O1323 CSF2 DUSP4 HEL-S-102 CPT1A EGR1 CXCL2 CLDN5 ZEB2 SLPI SHC1 MST1R ACACA SOCS3 PPARGC1A PCNA PLCG1 SMAD1 SMAD9 KLK15 NR0B2 FOS SNAI2 SP7 FGFR1 IL1B SRC MAP2K1 MAP2K2 TNF RELA MAPK9 PIK3R1 KDR MTOR MAPK1 CCL2 IFNB1 RAF1 IL10 JUN MAPK3 TJP1 MAPK14 RPS6KA4 RPS6KA5 RPS6KA1 SMAD2 GSK3B PARP1 RPS6 RPS6KB1 PRKCB MAPK8 VEGFA IL6 TGFB1 PDPK1 GRB2 HK2 IL10 ANTI INFLAMMATORY SIGNALING%WIKIPATHWAYS_20260810%WP4495%HOMO SAPIENS IL10 anti inflammatory signaling HMOX1 IL1A IL6 STAT2 JAK1 IL10 STAT1 STAT3 HEL-S-10 IL10RB IL10RA ENVELOPE PROTEINS AND THEIR POTENTIAL ROLES IN EDMD PHYSIOPATHOLOGY%WIKIPATHWAYS_20260810%WP4535%HOMO SAPIENS Envelope proteins and their potential roles in EDMD physiopathology ADCY3 ADCY1 SYNE4 ADCY8 SYNE3 ADCY6 HRAS SYNE2 SYNE1 MAP2K1 ADCY5 HEL-S-15 MAP2K2 HEL-S-7a TMEM43 CTGF LBR EMD HEL-S-61 SOS1 WWTR1 SOS2 SUN1 LEMD3 NRAS YY1AP1 MAPK1 ADCY9 PLEC MAPK3 SMAD2 ARHA BANF1 SMAD4 TGFB1 GRB2 PLATELET MEDIATED INTERACTIONS WITH VASCULAR AND CIRCULATING CELLS%WIKIPATHWAYS_20260810%WP4462%HOMO SAPIENS Platelet mediated interactions with vascular and circulating cells IL1B SELE TLR7 CD40 TLR4 CCL5 CD40LG CCL2 SELPLG SELP TGFB1 PF4 VCAM1 HEREDITARY LEIOMYOMATOSIS AND RENAL CELL CARCINOMA PATHWAY%WIKIPATHWAYS_20260810%WP4206%HOMO SAPIENS Hereditary leiomyomatosis and renal cell carcinoma pathway PDHA1 HEL-S-133P PRKAA1 RPS6 PRKAG1 ACACA VEGFA PRKAB1 EGLN1 PDHA2 SLC11A2 NFE2L2 KEAP1 HIF1A ACACB PRIMARY FOCAL SEGMENTAL GLOMERULOSCLEROSIS FSGS %WIKIPATHWAYS_20260810%WP2572%HOMO SAPIENS Primary focal segmental glomerulosclerosis FSGS NPHS1 NPHS2 YWHAQ WT1 LRP5 FAT1 AGRN LIMS1 LRP6 LAMB2 ITGB3 ITGAV ITGB1 HEL113 CLDN1 CDH2 PLCE1 PCNA PLCG1 CDKN1B ITGB4 TLR4 FYN NOTCH1 CDKN1C SCARB2 SMARCAL1 PTPRO HEL114 MKI67 CTSL DAG1 WNT1 SYNPO NCK1 KIRREL3 TRPC6 KIRREL2 CR1 MME PLAUR ACTN4 HEL-S-28 DKK1 PAX2 CD2AP INF2 COL4A4 COL4A3 COL4A5 MYH9 IRF6 TGFB1 LMX1B TLN1 LAMA5 CD151 CD80 VTN CDKN1A PARVA MYO1E SEROTONIN TRANSPORTER ACTIVITY%WIKIPATHWAYS_20260810%WP1455%HOMO SAPIENS Serotonin transporter activity MAOA IL1B TPH2 IL1R1 TGFB1I1 STX1A ITGB3 PDGF PATHWAY%WIKIPATHWAYS_20260810%WP2526%HOMO SAPIENS PDGF pathway NFKB1 SRC HRAS MAP2K1 WASL CDC42 STAT1 PAK1 STAT3 COX2 VAV1 VAV2 SOS1 PIK3R1 TIAM1 MAPK1 RAF1 RAC1 JAK1 JUN MAPK3 PDGFA PTPN11 NFKBIA MAPK8 ARHA SHC1 PLCG1 MAP2K4 MAP3K1 CHUK FOS GRB2 FLUOROPYRIMIDINE ACTIVITY%WIKIPATHWAYS_20260810%WP1601%HOMO SAPIENS Fluoropyrimidine activity CDA DPYS TYMP TDG FPGS UPP2 TK1 ABCC3 RRM1 RRM2 ABCC5 XRCC3 GGH SMUG1 UCK2 CYP2A6 UCK1 DPYD ERCC2 UMPS SLC29A1 SLC22A7 ABCG2 CES2 CES1 TYMS DHFR CARDIOMYOCYTE SIGNALING CONVERGING ON TITIN%WIKIPATHWAYS_20260810%WP5344%HOMO SAPIENS Cardiomyocyte signaling converging on titin MAP2K1 MAP2K2 MAPK1 RAF1 PRKCA GUCY1B1 MDM2 FHL1 CAMK2A ADRB1 ADRB2 MYPN TTN CSRP3 PRKACG NUP62 ANKRD1 ANKRD2 HEL-S-101 FHL2 TRIM63 ANKRD23 C22orf13 PRKAR1A NBR1 TCAP TRIM55 TARGETING YAP IN PANCREATIC DUCTAL ADENOCARCINOMA PDAC %WIKIPATHWAYS_20260810%WP5495%HOMO SAPIENS Targeting YAP in pancreatic ductal adenocarcinoma PDAC RHO YAP1 PRKAA2 TEAD2 PRKAA1 TEAD3 TEAD4 LATS1 MOB1A CTGF LATS2 ARHA PRKAB2 PRKAG1 PRKAG2 PRKAB1 PRKAG3 HMGCR STK4 RHOD CYR61 RHOB ASPIRIN PREVENTION OF CANCER METASTASIS%WIKIPATHWAYS_20260810%WP5518%HOMO SAPIENS Aspirin prevention of cancer metastasis ARHA GNA13 TBXA2R ARHGEF1 PTGS1 MAPK SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260810%WP5530%HOMO SAPIENS MAPK signaling and ARTD family members MAP3K8 TNKS MAP3K21 MAP2K3 PARP14 MAP2K1 MAP3K10 MAP3K12 MAP2K2 MAPK9 MAPK1 MAPK12 RAF1 MAPK13 MAPK10 MAP3K11 MAP2K6 MAP3K5 MAPK11 MAPK3 MAPK14 ARAF PARP1 MAPK8 ATF4 MAP3K7 BRAF MAP2K4 MAP3K1 APOE AND MIR 146 IN INFLAMMATION AND ATHEROSCLEROSIS%WIKIPATHWAYS_20260810%WP3926%HOMO SAPIENS ApoE and miR 146 in inflammation and atherosclerosis TRAF6 IRAK1 TLR4 SPI1 RELA NFKB2 APOE BIOTIN METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260810%WP5031%HOMO SAPIENS Biotin metabolism including IMDs MCCC1 PCCB ACACA MCCC2 BTD PC PCCA ACACB HLCS SARS CORONAVIRUS AND INNATE IMMUNITY%WIKIPATHWAYS_20260810%WP4912%HOMO SAPIENS SARS coronavirus and innate immunity IFIH1 IFNAR2 IFNA13 IFNA14 IFNA16 TYK2 IFNA17 TLR3 STAT1 TICAM1 ACE2 IFNAR1 IRF9 IFNA10 IFNB1 STAT2 JAK1 IFNA21 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 IFNA8 IKBKE MAVS RIGI TBK1 IRF3 TRAF3 STEROID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP496%HOMO SAPIENS Steroid biosynthesis HSD3B2 HSD17B1 HSD17B2 HSD3B1 HSD17B4 HSD17B3 F13B HSD17B7 CYP17A1 CPN1 SUDDEN INFANT DEATH SYNDROME SIDS SUSCEPTIBILITY PATHWAYS%WIKIPATHWAYS_20260810%WP706%HOMO SAPIENS Sudden infant death syndrome SIDS susceptibility pathways NFKB1 TPH2 SP1 SP3 CEBPB NR3C1 CREBBP CREB1 PRKAR1A NR3A2 HEL-S-125m CHRM2 HEL2 IL1RN VIPR2 AQP4 RORA C4A GJA1 MYB PKNOX1 HEL-S-162eP CHRNB2 CHRNB4 MEF2C IL6R TSPYL1 POU3F2 RUNX3 SLC9A3 PRKAR1B EP300 DLX2 TPH1 ADCYAP1R1 CHRNA7 CREM HEL-S-93 BHLHB2 SLC1A3 GATA3 VEGFA GATA2 C4B_2 NEUROD1 IL6 DEAF1 MAP2 TF ChAT SCN3B SPTBN1 PPARGC1B NKX2-2 POU5F1 CAV3 BDNF HTR1A G6PC1 PBX1 YWHAQ PHOX2B PHOX2A HEL-S-1 TLX3 FEV GNB3 CC2D1A TP73 RET SNAP25 RYR2 ECE1 CTCF YBX1 HTR2A FOXM1 FREP1 SCN5A ACADM YWHAG NFYA SNTA1 NKX3-1 IL13 EN1 TACR1 SSTR2 NGF HADHB NFKB2 NOS1AP AVP SCN4B SLC25A4 VAMP2 DDC HEL-S-87p ASCL1 NR1A2 HSPD1 HES1 HES5 CXCL8 NTRK2 KCNJ8 GCK CPT1A EGR1 GRIN1 REST SST GPD1L HDAC1 PPARGC1A SOX2 IL1B TNF CASP3 IL10 JUN HIF1A TH MAOA PAH IL1A POU2F2 TCF3 LMX1B APOPTOSIS MODULATION BY HSP70%WIKIPATHWAYS_20260810%WP384%HOMO SAPIENS Apoptosis modulation by HSP70 NFKB1 TNFRSF1A APAF1 CASP3 CASP8 AIFM1 CASP6 CASP2 MAPK10 RIPK1 MAP3K1 TNFSF6 FADD CYCS CASP9 CEREBRAL ORGANIC ACIDURIAS INCLUDING DISEASES%WIKIPATHWAYS_20260810%WP4519%HOMO SAPIENS Cerebral organic acidurias including diseases HEL-S-5 GCDH MDH2 D2HGDH L2HGDH ALDH7A1 ADHFE1 GENES CONTROLLING NEPHROGENESIS%WIKIPATHWAYS_20260810%WP4823%HOMO SAPIENS Genes controlling nephrogenesis SLIT2 NPHS1 EMX2 NPHS2 FOXD1 WT1 EYA1 ETV4 CXCL12 GDNF TCF2 FGFR2 RET CXCR4 WNT4 KDR CD36 LAMB2 ITGB1 SHH SIX1 FGF8 NCK1 MAFB LHX1 HEL-S-28 PAX2 CD2AP VEGFA GLI3 ROBO2 NOTCH2 LMX1B FOXC2 FOXC1 TCF21 HOXD11 HOXA11 NCK2 PDGFR BETA PATHWAY%WIKIPATHWAYS_20260810%WP3972%HOMO SAPIENS PDGFR beta pathway HRAS MAP2K1 EIF2AK2 STAT1 STAT3 PRKCB MAPK8 SOS1 PIK3R1 SHC1 STAT5B RAF1 PLCG1 MAP2K4 JAK1 JUN MAP3K1 FOS MAPK3 GRB2 PRKCA UREA CYCLE AND ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260810%WP4595%HOMO SAPIENS Urea cycle and associated pathways FH MDH2 GOT2 NOS2 ARG1 HEL-S-281 GLUD1 ASS1 SLC25A15 ASL NAGS SLC25A12 SLC25A13 OTC HEL-S-32 GLS2 GPT INDUCTION OF AUTOPHAGY AND TOLL LIKE RECEPTOR SIGNALING BY GRAPHENE OXIDE %WIKIPATHWAYS_20260810%WP5336%HOMO SAPIENS Induction of autophagy and toll like receptor signaling by graphene oxide TRAF6 NFKB1 MAP1LC3A TLR9 MYD88 IFNG IFNB1 TLR4 TNF IRF3 HIPPO MERLIN SIGNALING DYSREGULATION%WIKIPATHWAYS_20260810%WP4541%HOMO SAPIENS Hippo Merlin signaling dysregulation HRAS FGFR2 DDB1 PAK1 FOXM1 NRAS PDGFRA CDH18 ITGB3 ITGAV ITGB1 ITGA1 FLT1 IGF1R CDH2 NTRK2 ITGB6 EGFR CCND1 PRKACG PRKAR1A FGFR1 CDH8 CDH6 ITGB4 CTGF WWTR1 KDR ITGAM FLT3 CSF1R FLT4 ITGA2B ITGAE CDH9 AMOT DCAF1 PPP1CC CDH4 ITGAX ITGB8 HEL-S-80p ITGB7 ITGA4 YAP1 ITGA2 RBX1 CDH10 CDH11 TEAD2 CDH12 TEAD3 ITGA7 MYC TEAD4 ITGA6 LATS1 PRKAR1B CDH15 CDH16 AJUBA PLCB4 CDH17 NF2 LATS2 VGLL4 CDH19 EPHA2 CTNNA1 CDH24 PAK6 PAK4 NTRK1 PPP1R14A NGFR KIT INSR CUL4A LIN28B FGFR4 FGFR3 CD44 SLC25A46 PATHWAY%WIKIPATHWAYS_20260810%WP5521%HOMO SAPIENS SLC25A46 pathway IMMT TMEM85 COX4NB EMC10 MICOS13 MICOS10 APOO CHCHD3 OPA1 CHCHD6 EMC1 EMC2 EMC3 MFN1 MFN2 EMC6 EMC7 APOOL MMGT1 RALA DOWNSTREAM REGULATED GENES%WIKIPATHWAYS_20260810%WP2290%HOMO SAPIENS RalA downstream regulated genes RALBP1 RALA NRAS EXOC8 RAC3 YBX3 RAC1 HRAS EXOC2 CDC42 TOLL LIKE RECEPTOR SIGNALING RELATED TO MYD88%WIKIPATHWAYS_20260810%WP3858%HOMO SAPIENS Toll like receptor signaling related to MyD88 NFKB1 TRAF6 TLR9 IRF7 TICAM2 TLR8 TLR7 TLR5 TLR4 TLR3 TICAM1 RELA MAPK1 IRAK1 NFKB2 MYD88 IKBKB RELB IKBKG IKBKE REL IRAK4 CHUK TIRAP TLR1 TBK1 IRF3 TRAF3 JAK STAT SIGNALING IN THE REGULATION OF BETA CELLS%WIKIPATHWAYS_20260810%WP5358%HOMO SAPIENS JAK STAT signaling in the regulation of beta cells CCND3 HRAS CCND2 CISH STAT1 STAT3 FOXM1 SOCS2 MTOR NRAS IFNG SOCS1 GHR IFNGR1 IFNGR2 EPOR EPO GH1 AKT1S1 RPTOR CDK4 AKT3 IL6R PRL MLST8 STAT5B SOCS3 PRLR IL6 STEROL REGULATORY ELEMENT BINDING PROTEINS SREBP SIGNALING%WIKIPATHWAYS_20260810%WP1982%HOMO SAPIENS Sterol regulatory element binding proteins SREBP signaling LDLR FASN NFYA GSK3A DBI MED15 CAMP HMGCS1 SREBF2 RBP4 SP1 IDI1 GPAM SEC23A SAR1A INSIG1 PRKAA2 DKFZp434B2017 RNF139 ACSS1 SEC23B SEC31B YY1 FDFT1 FGF21 SEC31A FDPS MBTPS1 AMFR ACACA NR1H2 CYP51A1 SQLE LPIN1 CDK8 CREB1 SCD SEC24C MBTPS2 PRKAA1 MVD PRKAB2 MTOR PRKAG1 PRKAG2 PRKAB1 PRKAG3 INS ACLY SIRT1 PPARG SCARB1 HEL-S-32 LPL HMGCR PPARGC1B CALORIC RESTRICTION AND AGING%WIKIPATHWAYS_20260810%WP4191%HOMO SAPIENS Caloric restriction and aging IGF1 PRKAB2 MTOR SIRT1 PPARGC1A NAMPT NEURAL CREST DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2064%HOMO SAPIENS Neural crest differentiation PAX3 CTBP2 NFKB1 PHOX2B FGFR2 DVL1 DVL2 DVL3 FZD3 TCF7L1 NFKB2 ITGB1 ASCL1 HES1 CDH2 HES5 HDAC5 HDAC2 HDAC3 HDAC10 HDAC1 SMAD1 HDAC8 NOTCH2 HDAC7 HDAC11 SNAI2 RBPJ DMBX1 FGFR1 MPZ ZIC1 HEY2 RHOB HOXA1 CDH6 SOX9 SOX5 MSX2 MIA OLIG3 OLIG1 OLIG2 SOX10 ISL1 COL2A1 DCT PAX7 HAND1 HOXB1 NOTCH3 DLX5 NOTCH4 COL11A2 WNT8A TWIST1 DLL3 DLL4 PRTG GBX2 NOTCH1 MBP MSX1 TFAP2B TFAP2A ZIC5 TBX6 BMP7 GFAP GJB1 MYB TLX2 FGF19 FGF8 ID1 SNAI1 PMP22 WNT1 TCF4 LHX5 GSK3B NEUROG1 MYC WNT3A FGF2 LHX1 FOXD3 BMP4 AXIN1 AXIN2 FGFR3 MITOCHONDRIAL FATTY ACID SYNTHESIS PATHWAY%WIKIPATHWAYS_20260810%WP4317%HOMO SAPIENS Mitochondrial fatty acid synthesis pathway ACACA MECR OXSM HTD2 HSD17B12 MCAT STRIATED MUSCLE CONTRACTION PATHWAY%WIKIPATHWAYS_20260810%WP383%HOMO SAPIENS Striated muscle contraction pathway MYL2 MYL3 TNNT3 MYH8 MYH6 DMD ACTA2 HEL113 MYOM1 TTN HEL-S-273 ACTN4 ACTG1 TNNI1 TNNI2 TNNI3 HEL-S-108 TPM3 MYBPC3 TMOD1 ACTN2 TNNC1 TPM1 TNNC2 TCAP MYL4 ACTA1 DES MYL1 TNNT1 SENESCENCE ASSOCIATED SECRETORY PHENOTYPE SASP %WIKIPATHWAYS_20260810%WP3391%HOMO SAPIENS Senescence associated secretory phenotype SASP NFKB1 H2AC19 H2AB1 UBE2D1 EHMT1 CDC23 H2AC14 H2BC26 H2BC12L STAT3 H2BC21 CDC26 CDC27 HIST1H2AB VENTX H3C8 ANAPC7 H2AC6 H2BC9 H2BC17 CCNA2 H2BC13 H2AJ H2BC14 H2BC15 H2BC11 HIST1H2BE ANAPC5 ANAPC1 ANAPC2 ANAPC15 ANAPC10 ANAPC11 FZR1 H3C15 UBB UBC CEBPB C10orf104 IGFBP7 RPS27A CXCL8 CDKN2D H2AZ1 H2AZ2 CDKN2B CDKN2C H2BC8 CDKN2A H2BC3 H2BC1 UBE2S H2AC20 FOS H2AX CDKN1B UBE2E1 RELA MAPK1 JUN MAPK3 H2BC12 H4C9 HIST1H4L CDK6 IL1A RPS6KA2 RPS6KA1 CDK4 CDK2 MAPK7 IL6 H3F3B CDKN1A UBE2C METHYLATION PATHWAYS%WIKIPATHWAYS_20260810%WP704%HOMO SAPIENS Methylation pathways NNMT TPMT INMT PNMT MAT1A ERK PATHWAY IN HUNTINGTON 39 S DISEASE%WIKIPATHWAYS_20260810%WP3853%HOMO SAPIENS ERK pathway in Huntington 39 s disease RPS6KA5 HRAS MAP2K1 NTRK2 MAP2K2 EGFR CASP3 MAPK1 RAF1 CREB1 HTT MAPK3 EGF BDNF ALANINE AND ASPARTATE METABOLISM%WIKIPATHWAYS_20260810%WP106%HOMO SAPIENS Alanine and aspartate metabolism GAD1 ABAT GOT2 GAD2 AGXT ASPA GPT ASS1 PC ASL AMINO ACID METABOLISM PATHWAY EXCERPT HISTIDINE CATABOLISM EXTENSION%WIKIPATHWAYS_20260810%WP4661%HOMO SAPIENS Amino acid metabolism pathway excerpt histidine catabolism extension GLUD1 HAL UROC1 GPT2 FTCD FAS LIGAND PATHWAY AND STRESS INDUCTION OF HEAT SHOCK PROTEINS%WIKIPATHWAYS_20260810%WP314%HOMO SAPIENS Fas ligand pathway and stress induction of heat shock proteins RB1 PS1TP5BP1 ARHGDIB SPTAN1 CASP10 DFFB DFFA MAPKAPK3 RIPK2 NFX1 APAF1 TNF PAK1 CASP3 PRKDC JUN FADD SMIM40 IL1A PARP1 HEL-S-102 LMNB2 MAPK8 ACTG1 CASP8 LMNA MAPKAPK2 CASP6 MAP3K7 MAP2K4 MAP3K1 TNFSF6 BCL2 CYCS ACTA1 CASP9 FAF1 GENETIC CAUSES OF PORTO SINUSOIDAL VASCULAR DISEASE%WIKIPATHWAYS_20260810%WP5269%HOMO SAPIENS Genetic causes of porto sinusoidal vascular disease NFKB1 TLR9 TLR8 DOCK6 CYBC1 NCF1 NCF2 NCF4 CDC42 COX4I2 CXXC5 DGUOK CHCHD2 BTK C4orf54 NOTCH4 BEND6 GTF2I EFL1 MAPK1 CYBB CYBA DLL4 RAC1 SHCBP1 ARHGAP31 IBTK NOTCH1 EIF6 MAPK3 SBDS NOX3 SP1 KCNN3 RBPJ GPCRS CLASS B SECRETIN LIKE%WIKIPATHWAYS_20260810%WP334%HOMO SAPIENS GPCRs class B secretin like SCTR PTH1R GPR64 CRHR2 GHRHR CALCR ADGRE5 ADGRL1 ADGRL4 ADGRL2 ADGRL3 ADCYAP1R1 GLP1R CALCRL VIPR2 GIPR GCGR NOVEL INTRACELLULAR COMPONENTS OF RIG I LIKE RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP3865%HOMO SAPIENS Novel intracellular components of RIG I like receptor pathway IFIH1 NFKB1 CASP10 RIPK1 FADD NFKBIA CYLD CXCL8 IFNA1 CASP8 IRF3 TRAF3 TRAF6 IRF7 CXCL12 TNF RELA MAPK9 IFNG IFNB1 MAPK12 MAPK13 MAPK10 MAPK11 MAPK14 DDX3Y TRADD IKBKB DKFZp686F0183 DHX58 TRIM25 MAPK8 AZI2 TRAF2 IKBKG MITA IKBKE ATG12 MAP3K7 SIKE1 RNF125 IFNE IFNK NLRX1 TANK MAVS MAP3K1 ISG15 CHUK SNW1 PIN1 OTUD5 TBKBP1 RIGI NFKBIB TBK1 DDX3X METABOLIC PATHWAYS OF FIBROBLASTS%WIKIPATHWAYS_20260810%WP5312%HOMO SAPIENS Metabolic pathways of fibroblasts PLOD1 P3H3 LOXL2 UGDH ADAMTS2 BMP1 P4HA1 HEL-S-133P P4HA2 PSAT1 P4HA3 PHGDH GLUD1 ALDH18A1 GCK PSPH ARHA PLCG1 CD36 FGFR4 FGFR1 LPAR1 P3H4 GLS MIR TARGETED GENES IN SQUAMOUS CELL%WIKIPATHWAYS_20260810%WP2006%HOMO SAPIENS miR targeted genes in squamous cell GFPT1 P4HA2 CPNE8 VEZT PWP1 PNP DHX57 CIAO2A HOXA7 POGLUT3 GOLGA7 SLC38A1 RARS1 ATP6V0E1 FBXW11 FNDC3B FNDC3A NCL RAI14 SRSF9 POM121 PISD TMED10 CBFB ADIPOR2 RTN4 UBE2J1 MRPL20 SEC23A COMMD9 ATP6V1C1 ATP6V1F HMGA1 SLC4A10 TBCA PEDS1-UBE2V1 MOV10 CHMP2A SRPRB ANP32B DKFZp761E1322 RNP24 PICALM TPM3 ARF4 NRP1 TRAM1 ATP2A2 ADAR MRC2 GYS1 TUBA1A SPTLC1 SH3BGRL3 ELOVL5 PRPF40A HEL-S-26 CTDSP1 CSDE1 PXDN PTMA MRPS33 AKAP8 DNAJB1 POLR2C RHEB PPP1R7 POLD2 SH3BP4 E2F3 MAGT1 PDLIM7 MPZL1 SLC12A2 GALNT7 GALNT1 AP3D1 ARCN1 TMEM59 SPCS3 FMNL2 AXL NEDD4 LAMTOR5 CUL4B BET1 HSD17B12 ANXA2 TPM1 MAP3K8 YWHAQ AP2A1 TGFBR2 LAMC1 THBS1 HES1 TMED7 SMAD1 HMOX1 SYNE2 TMEM43 SDCBP GAS2L1 VCAM1 TNFRSF10B FGF2 NF2 HEL-S-30 FACTORS AND PATHWAYS AFFECTING INSULIN LIKE GROWTH FACTOR IGF1 AKT SIGNALING%WIKIPATHWAYS_20260810%WP3850%HOMO SAPIENS Factors and pathways affecting insulin like growth factor IGF1 Akt signaling IGF1 NFKB1 TNFRSF1A WASL MTOR MAP1LC3A EIF4E PTEN PRKAB1 MSTN AKT1S1 IRS1 MAPKAP1 ITGB1 DEPTOR RICTOR EIF2B2 RPTOR TNLG5A IGFBP5 FBXO32 ACVR2B IGF1R SMAD2 GSK3B RPS6KB1 HEL-S-28 MLST8 PPARGC1A TRIM63 ALPHA 6 BETA 4 SIGNALING%WIKIPATHWAYS_20260810%WP244%HOMO SAPIENS Alpha 6 beta 4 signaling SRC HRAS ITGB4 PIK3R2 SOS1 PIK3R1 MTOR EIF4EBP1 MAPK1 RAC1 MAPK3 LAMB2 IRS1 PRKCA PTPN11 MAPK14 LAMC1 LAMA1 LAMA3 LAMC2 LAMB3 LAMB1 ITGA6 ARHA SHC1 LAMA5 GRB2 T CELL ACTIVATION SARS COV 2%WIKIPATHWAYS_20260810%WP5098%HOMO SAPIENS T cell activation SARS CoV 2 IL12A LAT NFKB1 HLA-DRB1 IFNAR2 IL18R1 HRAS TYK2 SOS1 IFNAR1 IL4 STAT4 PTEN BAX NFKBIA MYD88 CCND1 CDKN2A MLST8 IL2 PLCG1 FOS BCL2L1 MAP2K1 RHEB MAP2K2 PIK3CD TNF TSC2 TSC1 RELA PIK3R1 MTOR IFNG MAPK1 IFNB1 RAF1 FYN JUN MAPK3 DEPTOR RICTOR RPTOR GSK3B IL23R CD3G IKBKB CD3E CD3D IRF2BPL IL17A PPP3CC GRAP2 IKBKG CTLA4 FOXO3A ZAP70 IL23A NFATC1 LCK LTA LCP2 CARD11 CHUK BCL10 CCL19 PDPK1 ICOS GRB2 CD80 IL12RB1 CDKN1A PRKCQ PTPRC IL12B CCL28 PANCREATIC ADENOCARCINOMA PATHWAY%WIKIPATHWAYS_20260810%WP4263%HOMO SAPIENS Pancreatic adenocarcinoma pathway NFKB1 TGFBR1 dik HEL-S-34 BRCA2 POLK RALB TGFA PLD2 DDB2 E2F2 TGFBR2 CDC42 BAK1 STAT1 PAK1 STAT3 RALBP1 RALA RAC3 BAD JAK1 BAX EGFR CCND1 CDKN2A ERBB2 SMAD4 CASP9 RB1 BCL2L1 MAP2K1 MAP2K2 PIK3CD PIK3R3 E2F3 RELA PIK3R2 MAPK9 PIK3R1 MTOR MAPK1 RAF1 RAC1 MAPK10 MAPK3 GADD45B GADD45A GADD45G CDK6 RAD51 CDK4 ARAF AKT3 SMAD2 RPS6KB1 IKBKB RPS6KB2 MAPK8 IKBKG VEGFA PAK6 PAK4 BRAF TGFB1 CHUK EGF CDKN1A STATIN INHIBITION OF CHOLESTEROL PRODUCTION%WIKIPATHWAYS_20260810%WP430%HOMO SAPIENS Statin inhibition of cholesterol production APOB LDLR APOA4 PLTP APOA5 CYP7A1 PDIA2 SOAT1 ABCG8 ABCG5 APOC3 APOC1 DGAT1 ACSS1 FDFT1 ABCA1 SQLE SCARB1 MTTP APOA2 LPL HMGCR LIPC APOC2 APOE ROBO4 AND VEGF SIGNALING CROSSTALK%WIKIPATHWAYS_20260810%WP3943%HOMO SAPIENS ROBO4 and VEGF signaling crosstalk SLIT2 KDR VEGFA ROBO4 SRC RAC1 LIPID METABOLISM PATHWAY%WIKIPATHWAYS_20260810%WP3965%HOMO SAPIENS Lipid metabolism pathway PDHA1 ACLY AKT3 PRKAA2 PRKAA1 PNPLA2 PRKAR1B ACSS2 FASN PRKACG PRKAB2 HILPDA PRKAG1 ABHD5 ACACA PRKAG2 LIPE PLIN1 PRKAB1 PRKAR1A PRKAG3 BURN WOUND HEALING%WIKIPATHWAYS_20260810%WP5055%HOMO SAPIENS Burn wound healing NFKB1 MMP9 FGFR2 CXCR4 ACHE FOXE1 BAX HEXD TNC F13A1 HMGB1 MMP28 TIMP1 KRT222 IL15 DCN S100A6 PECAM1 S100A9 MYD88 CXCL1 PCTK1 FLG COL1A2 TAGLN IL8RB SCEL BRD4 CXCL8 AMBP HEL-S-43 KLF4 IFNA2 SLURP1 LIN28A NOX4 TPT1 MMP2 SNAI2 FGFR1 IL1B KRT6A CXCL12 TLR4 TNF CASP3 CCL2 IFNB1 COL1A1 HGF CD3E FST CHRNA7 INHBA VEGFA IL6 FBN1 BCL2 EGF ACTA1 FGFR4 FGFR3 DEREGULATING CELLULAR METABOLISM THROUGH NON GENOTOXIC CARCINOGENS%WIKIPATHWAYS_20260810%WP5571%HOMO SAPIENS Deregulating cellular metabolism through non genotoxic carcinogens HSPD1 MYC TSC2 TSC1 ATF4 GDF15 MARS1 MTOR OMA1 PHB2 SLC7A7 CLPP SESN2 LONP1 LONP2 EIF2A IRS1 FOXO1 SCFA AND SKELETAL MUSCLE SUBSTRATE METABOLISM%WIKIPATHWAYS_20260810%WP4030%HOMO SAPIENS SCFA and skeletal muscle substrate metabolism FFAR3 NR1C2 PYY FFAR2 GCG SLC2A4 INFLAMMATORY RESPONSE PATHWAY%WIKIPATHWAYS_20260810%WP453%HOMO SAPIENS Inflammatory response pathway THBS3 TNFRSF1B IL5 TNFRSF1A IL2RA IL2RB IL4 IFNG LAMB2 LAMC1 THBS1 COL1A1 COL3A1 COL1A2 CD40 LAMC2 LAMB1 IL2 ZAP70 CD40LG LCK LAMA5 CD80 VTN IL5RA IL2RG PURINERGIC SIGNALING%WIKIPATHWAYS_20260810%WP4900%HOMO SAPIENS Purinergic signaling GNAZ LPAR4 PANX1 P2RY8 P2RY6 GNAT2 P2RY4 GNAT3 P2RY2 GNA11 P2RY1 GNAT1 P2RY13 P2RY10 P2RY11 P2RY14 GNAO1 P2RX7 P2RX6 P2RX5 P2RX4 ADORA2A P2RX3 ADORA2B GNAI3 P2RX2 GNAI1 P2RX1 GNAS RENIN ANGIOTENSIN SYSTEM AND BRADYKININ PATHWAYS IN COVID 19%WIKIPATHWAYS_20260810%WP4969%HOMO SAPIENS Renin Angiotensin System and Bradykinin pathways in COVID 19 KNG1 IL1B NFKB1 BDKRB2 AGTR1 BDKRB1 IL1A SERPING1 ROCK1 CYP3A4 REN AGTR2 KLKB1 TNF ARHA ACE2 NR1i1 MAPK1 PRKG1 CYP24A1 CPN1 KLK1 ARTEMISININ INHIBITION OF UVEAL MELANOMA%WIKIPATHWAYS_20260810%WP5441%HOMO SAPIENS Artemisinin inhibition of uveal melanoma MTOR AKT3 GLP 1 IN PANCREATIC ISLET CELLS%WIKIPATHWAYS_20260810%WP5447%HOMO SAPIENS GLP 1 in pancreatic islet cells IL6 IL6R SLC2A2 GLP1R GCG INS ANGIOGENESIS OVERVIEW%WIKIPATHWAYS_20260810%WP1993%HOMO SAPIENS Angiogenesis overview APC MMP9 CDC42 PAK1 SOS1 BAD PLA2G1B ATF2 NOX4 MMP2 SHC1 NRP1 PLCG1 FGFR1 SLIT2 ROBO4 SRC MAP2K1 PIK3CD KDR MTOR PTK2B MAPK1 RAF1 RAC1 MAP2K6 MAPK11 PRKCA PTPN11 MAPK14 DAG1 NCK1 PLXND1 SHB ROBO1 GRB14 TIMP4 FRS2 MAPK8 F2 MMP14 CRK GRB7 MAP3K7 SEMA3A VEGFA PXN WAS IQGAP1 MAP2K4 VHL ANGPT1 BMX PDPK1 GRB2 GNAQ P R183Q DRIVES CAPILLARY MALFORMATION%WIKIPATHWAYS_20260810%WP5501%HOMO SAPIENS GNAQ p R183Q drives capillary malformation PRKCZ PKN3 PRKD1 PRKCB PPP3CA PLCB3 PPP3CC PKN2 PRKCI PKN1 PRKCH NFATC1 PRKCE ANGPT2 RCAN1 PPP3R1 PRKCA PPP3R2 PRKD3 PRKCQ PRKD2 CHOLESTEROL BIOSYNTHESIS PATHWAY IN HEPATOCYTES%WIKIPATHWAYS_20260810%WP5329%HOMO SAPIENS Cholesterol biosynthesis pathway in hepatocytes MVK ELOVL2 IDI2 MSMO1 CYP46A1 ACAT2 TM7SF2 EBP SC5D MYLIP GGPS1 ELOVL3 NR1H3 CYP7A1 DHCR24 LBR ACSL3 MVD FADS2 PLPP6 ACSL1 CH25H ABCG1 CYP27A1 HSD17B7 HMGCS1 IDI1 FDFT1 FDPS NR1H2 CYP51A1 ABCA1 SCD HMGCR ELOVL5 ELOVL4 MIRNA ROLE IN IMMUNE RESPONSE IN SEPSIS%WIKIPATHWAYS_20260810%WP4329%HOMO SAPIENS miRNA role in immune response in sepsis NFKB1 TRAF6 IRF7 TLR8 TLR7 TLR4 TNF RELA IRF-1 CCL4 ELANE CCL3 LCN2 IRAK1 IL10 MAP3K7IP1 VCAM1 NFKB2 NFKBIA MAPK14 MYD88 IL1A CXCL8 IKBKB MAPK8 RELB IKBKG MAP3K7 REL IL6 IRAK4 CHUK TRAF3 MITOCHONDRIAL COMPLEX III ASSEMBLY%WIKIPATHWAYS_20260810%WP4921%HOMO SAPIENS Mitochondrial complex III assembly UQCRH CYC1 UQCRQ CYB UQCRFS1 UQCC3 UQCC2 TTC19 LYRM7 UQCRC1 UQCC UQCRC2 UQCRB UQCR11 UQCR10 BONE MORPHOGENIC PROTEIN SIGNALING AND REGULATION%WIKIPATHWAYS_20260810%WP1425%HOMO SAPIENS Bone morphogenic protein signaling and regulation SMURF1 BMPR1A SMAD4 SMAD1 BMP2 TOB2 TOB1 RUNX2 SMAD6 NOG MATRIX METALLOPROTEINASES%WIKIPATHWAYS_20260810%WP129%HOMO SAPIENS Matrix metalloproteinases MMP9 TNF MMP28 TCF20 TIMP1 MMP21 MMP20 MMP25 MMP24 MMP27 MMP26 TIMP3 MMP10 MMP12 MMP11 hEMMPRIN MMP16 MMP15 MMP23B MMP17 TIMP4 MMP19 MMP14 MMP2 MMP3 MMP7 FATTY ACID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP357%HOMO SAPIENS Fatty acid biosynthesis ACLY MECR ACSL3 PC PECR ECHS1 ACSS2 ACSL1 FASN ACSL6 FACL4 ACSL5 ACACA ECHDC1 ECHDC2 DECR1 SCD ACACB JAK STAT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260810%WP5528%HOMO SAPIENS JAK STAT signaling and ARTD family members HDAC3 RBX1 PARP11 DTX3L PARP14 BTRC SKP1 PARP1 STAT1 STAT3 HDAC2 SOX GENES AND THEIR INFLUENCE ON NEUROGENESIS AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260810%WP5568%HOMO SAPIENS SOX genes and their influence on neurogenesis and neurodevelopmental disorders SOX2 SOX15 HIST1H4L ZSCAN10 POU3F2 TEAD2 WWTR1 YES1 SRRT SOX4 SOX11 SOX12 H4C9 POU3F1 FGF4 UTF1 MICROTUBULE CYTOSKELETON REGULATION%WIKIPATHWAYS_20260810%WP2038%HOMO SAPIENS Microtubule cytoskeleton regulation RHO AURKB SPRED1 PARD6A CFL2 SRC CLASP1 MARK1 NTRK3 APC LIMK1 DVL1 TAOK1 CDC42 CAMK4 PAK1 STAT3 MAP1B MAPRE1 PHLDB2 F2RL2 TIAM1 FREP1 RAC1 PTEN PRKCA CDC2 TRIO ROCK1 GSK3B EPHB2 NTRK2 WNT3A MAPKAPK2 NTRK1 MEVALONATE PATHWAY%WIKIPATHWAYS_20260810%WP3963%HOMO SAPIENS Mevalonate pathway FDPS MVK HMGCS1 ACAT2 HMGCR MVD ANDROGEN BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5393%HOMO SAPIENS Androgen biosynthesis AKR1C2 AKR1C4 CYP3A4 AKR1D1 CYP3A7 SULT2A1 HSD3B2 HSD17B1 SRD5A2 HSD17B2 HSD3B1 HSD17B4 HSD17B3 CYP17A1 HSD11B1 HSD11B2 POR AKR1C1 DOWNREGULATION OF ACE2 BY SARS COV 2 SPIKE PROTEIN%WIKIPATHWAYS_20260810%WP4799%HOMO SAPIENS Downregulation of ACE2 by SARS CoV 2 spike protein ACE2 AGTR1 AGTR2 CHOLESTEROL BIOSYNTHESIS WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260810%WP4804%HOMO SAPIENS Cholesterol biosynthesis with skeletal dysplasias CYP51A1 EBP SC5D DHCR7 DHCR24 LBR MIRNA REGULATION OF DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260810%WP1530%HOMO SAPIENS miRNA regulation of DNA damage response APAF1 DDB2 CCNB1 BAX CCND1 CASP8 CREB1 CASP9 RB1 H2AX CDKN1B HUS1B TP53AIP1 PIDD1 CCND3 CCND2 CHEK2 SESN1 CHEK1 TLK2 TLK1 BBC3 NBN RFC1 SMC1A CASP3 CCNE2 RRM2B FANCD2 CCNE1 CCNG1 PRKDC CCNB3 CCNB2 PMAIP1 SFN ATRIP GADD45B GADD45A MRE11A TNFRSF10B PML CDC2 GADD45G RAD52 RAD50 CDK6 RAD51 CDK5 CDK4 CDK2 MDM2 RAD17 MYC RAD1 ATM RAD9A ATR CYCS CDKN1A MITOCHONDRIAL CARRIER DEFICIENCY ASSOCIATED WITH SHUTTLE DISTURBANCES%WIKIPATHWAYS_20260810%WP5507%HOMO SAPIENS Mitochondrial carrier deficiency associated with shuttle disturbances SLC25A12 SLC25A13 SLC25A22 GOT2 GLUD1 PHOTODYNAMIC THERAPY INDUCED AP 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260810%WP3611%HOMO SAPIENS Photodynamic therapy induced AP 1 survival signaling RB1 TRAF6 TNFRSF1A BCL2L1 MAP2K3 TNF BAK1 BCL2L11 CCNE1 IFNG FGF7 MAPK12 TNFSF10 MAPK13 CCNA2 BMF BAX JUNB MAP2K6 MAP3K5 MCL1 PDGFRA JUN MAPK11 TRAF5 HBEGF NFE2L2 MAPK14 EGFR ATF2 MAPK8 CCND1 CDKN2A TRAF2 MMP2 IL2 IL6 MAP2K4 TNFSF6 FOS BCL2 CDKN1A LUNG FIBROSIS%WIKIPATHWAYS_20260810%WP3624%HOMO SAPIENS Lung fibrosis IGF1 TGFA MMP9 CCL11 IL4 IL13 TIMP1 CSF3 CEBPB CXCL8 CSF2 CXCL2 MMP2 opn IL1B HMOX1 IL5 TNF SFTPA2 CTGF CCL5 CCL4 CCL3 CCL2 FGF7 SKIL NFE2L2 SERPINA1 PDGFA FAM13A MT2A BMP7 KPG_011 CCR3 CCR2 EDN1 ELMOD2 SFTPC ATP11A GREM1 CALCA RTEL1 TERT DPP9 FGF2 HGF STN1 CMA1 MUC5B PTX3 SFTPA1 IL6 TGFB1 EGF IL12B EXERCISE INDUCED CIRCADIAN REGULATION%WIKIPATHWAYS_20260810%WP410%HOMO SAPIENS Exercise induced circadian regulation NR1D2 HEL-S-22 ETV6 PER2 PER1 PSMA4 AAG1 VAPA PPP1R3C KLF9 CRY2 CRY1 MYF6 PIGF H2BC15 TOB1 IDI1 CEBPB CLDN5 NCKAP1 DAZAP2 BTG1 PURA HLA-DMA SUMO1 STBD1 SUMO3 UCP3 QK3 ERC2 GSTM3 CBX3 ZFR HEL-S-72p G0S2 5Q35 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5380%HOMO SAPIENS 5q35 copy number variation CYP7A1 PRR7 COX2 COX7B CXCR4 KIAA1191 SOS1 FAF2 COX7C CLTB DDX41 TRIAP1 ABHD5 SNCA COX6A1 BABAM1 BABAM2 HK3 UIMC1 CAPN3 NELFB KDM6B ARL10 PTH COX8A TMED9 RNF44 COX5A UNC5A TMED10 EED FBXW7 SLC34A1 MYO7B ADAM10 COX6B1 IGF1R ARFGAP2 HIC2 DOK3 EIF4E1B PNPLA2 GPRIN1 CDHR2 FAM193B GRIN1 PFN3 DBN1 RGS14 MAX MAGED1 RNP24 ABRAXAS1 USH1C BRCC3 COX7A1 PLCG1 LMAN2 RAB24 COX3 COX1 ZNF346 SNCB DRD2 BARD1 PRELID1 PTPRN2 H2AX NOP16 MUPCDH GRIN2B HIGD2A TSPAN17 SRC ANKS4B MXD3 NTN1 PDLIM7 MAPK9 PIK3R1 INPP5D MAPK10 JUN GNAI3 GNAI1 FGF19 MYC FRS2 MAPK8 HEL-S-273 GRB2 FGFR4 H3F3B POST COVID NEUROINFLAMMATION%WIKIPATHWAYS_20260810%WP5485%HOMO SAPIENS Post COVID neuroinflammation IL1B IL12A IL1A TLR8 TLR7 TMPRSS2 FURIN TLR4 CXCL8 CCL11 TLR3 IL18 TNF IFNA2 ACE2 IL2 IL4 IFNG MAPK1 IL6 IL10 HMGB1 GFAP BILE ACID SYNTHESIS AND ENTEROHEPATIC CIRCULATION %WIKIPATHWAYS_20260810%WP4389%HOMO SAPIENS Bile acid synthesis and enterohepatic circulation LDLR FGF19 MAPK1 FXR1 MAPK3 SLC10A2 FGFR4 ABCB11 CYP7A1 ABCG8 ABCG5 EICOSANOID SYNTHESIS%WIKIPATHWAYS_20260810%WP167%HOMO SAPIENS Eicosanoid synthesis PTGS1 PTGIS PTGS2 PLA2G4B ALOX15 ALOX12 ALOX5 PLA2G5 LTC4S PLA2G6 ALOX15B PRXL2B ALOX5AP PTGES GANGLIO SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260810%WP1423%HOMO SAPIENS Ganglio sphingolipid metabolism ST6GALNAC6 ST8SIA1 SLC33A1 B3GALT4 B3GALT1 ST8SIA5 ST3GAL5 FUT1 B4GALNT1 A3GALT2 ST3GAL1 SUPPRESSION OF HMGB1 MEDIATED INFLAMMATION BY THBD%WIKIPATHWAYS_20260810%WP4479%HOMO SAPIENS Suppression of HMGB1 mediated inflammation by THBD THBD IKBKG NFKB1 AGER CHUK HMGB1 IKBKB RELA NFKBIA NON HOMOLOGOUS END JOINING%WIKIPATHWAYS_20260810%WP438%HOMO SAPIENS Non homologous end joining XRCC5 PRKDC POLM POLL NHEJ1 WRN IRON METABOLISM IN PLACENTA%WIKIPATHWAYS_20260810%WP2007%HOMO SAPIENS Iron metabolism in placenta STEAP3 TF HEPHL1 TFRC TFR2 IREB2 SLC11A2 SLC40A1 MCOLN1 HAMP HEL60 FOCAL ADHESION PI3K AKT MTOR SIGNALING%WIKIPATHWAYS_20260810%WP3932%HOMO SAPIENS Focal adhesion PI3K Akt mTOR signaling IGF1 GNGT1 GYS2 GNGT2 RAB8A STRADA OSMR PHLPP2 PHLPP1 CAB39 RELN FGFR2 VEGFB OSM VEGFC VEGFD CSHL1 RAB11B GHB3 FOXA1 CRTC2 CSF3R CHRM1 IRS4 FGF3 JAK1 COMP FGF6 STK11 FGF9 TNR RAB2A F2R COL4A6 PFKFB2 PFKFB1 PFKFB4 EFNA5 EFNA4 CHAD FGF20 FGF22 FGF17 PRL EFNA1 FGF16 EFNA3 FGF14 EGFR EFNA2 GNB2 FGF18 GNB1 GNB4 IL7R FGF13 FGF12 HSP90AB1 SLC2A3 PRLR ELAVL1 VWF CREB1 PPP2R5B PPP2R5A GYS1 PPP2R5D IL3RA THBS4 FOXO1 GNG3 GNG2 GNG5 GNG4 PPP2R3C GNG7 GNG8 ANGPT4 RAB10 PIK3IP1 RAB14 PPP2R2D HEL-S-125m CSF1R CHRM2 CSF1 EPO PDGFA IRS1 INS FGF4 RPTOR FGF8 LAMA1 IL6R LAMA3 LAMC2 EIF4B LAMB3 RPS6 LAMB1 HGF RPS6KB1 RPS6KB2 FOXO3A VEGFA KITLG KIT FGF10 IFNAR2 GNB3 IFNAR1 LIPE PIK3R5 PTEN PIK3R4 TNC NGF PIK3C2B IFNA7 MLST8 opn SLC2A4 IL2RG THBS3 CDKN1B IL2RA IL2RB LPAR4 NOS2 IFNB1 ITGAM FLT4 ITGA2B ITGAE ITGAX ITGB8 ITGB7 ITGA4 ITGA2 MDM2 SLC2A2 ITGA7 ITGA6 EPHA2 NGFR ANGPT1 INSR ANGPT2 FGFR4 FGFR3 GHR PDGFRA IBSP EPOR AKT1S1 ITGB3 ITGAV PRKAA2 FGF21 IL2 CASP9 MAP2K1 RHEB PRKAA1 COL2A1 MAP2K2 PIK3CD TSC2 TSC1 PIK3R2 PIK3R1 COL11A2 MTOR EIF4EBP1 MAPK1 FGF7 RAF1 EIF4E MAPK3 FGF19 AKT3 CREB3L3 CREB3L4 CREB3L2 PPP2R5E PPP2R1A ATF4 PPP2R5C GRB2 CDKN1A JAK3 HRAS PPP2CA CREB3 SOS1 CREB5 ATF6B NRAS BAD PPP2R3A LAMB2 LAMA4 PPP2R2C PPP2R2B ITGB1 XB CSF3 FLT1 LAMC1 THBS2 THBS1 COL3A1 COL1A2 COL4A2 IGF1R COL4A1 COL5A3 EIF4E1B COL5A2 ITGB6 ATF2 ACACA PPARGC1A FGFR1 ITGB4 PPP2R1B KDR HIF1A COL1A1 GSK3B FGF2 IKBKB TCL1B TCL1A IKBKG KPG_010 PELO CDC37 COL4A4 DDIT4 ULK1 LPAR2 LPAR3 GNG10 PDGFD PDGFC LAMA5 EGF GNG12 PDPK1 GNG11 VTN LPAR1 GNG13 HIF3A INVOLVEMENT OF SECRETASE IN NEURODEGENERATIVE DISEASES%WIKIPATHWAYS_20260810%WP5372%HOMO SAPIENS Involvement of secretase in neurodegenerative diseases SNCA CEBPB AKT3 SRPK2 BACE1 NTRK2 APP STAT1 SET TARDBP BDNF RELATIONSHIP BETWEEN INFLAMMATION COX 2 AND EGFR%WIKIPATHWAYS_20260810%WP4483%HOMO SAPIENS Relationship between inflammation COX 2 and EGFR SRC HRAS AKT3 PIK3CD EGFR PTGS2 PTGER4 PTGER1 PTGER2 PTGER3 PLA1A NRAS MAPK1 BRAF MAPK3 CLOCK CONTROLLED AUTOPHAGY IN BONE METABOLISM%WIKIPATHWAYS_20260810%WP5205%HOMO SAPIENS Clock controlled autophagy in bone metabolism NR1D2 IGF1 LRP5 PER1 CRY1 WNT10B SQSTM1 BMP2 HMGB1 RUNX2 PTH TNFRSF11B PRKAA2 DKFZp781O1323 TNFRSF11A SMAD4 SMAD1 SMAD9 SP7 NPAS2 CTSK TRAF6 MTOR BHLHE41 MAP1LC3A RORB ARHGAP4 FYCO1 RB1CC1 LAMP2 SOST NOTCH1 CSF1 ATG3 ATG10 DKFZp762B153 VCP CTF1 AMBRA1 EFNB2 ATG101 DRAM2 CTHRC1 SEMA4D TNFSF11 BMP6 BMP5 CALCA BMP3 ATG16L1 LEP PLEKHM1 DKFZp686F0183 DKK1 BHLHB2 ATG12 SEMA3A BMP4 NFATC1 IL3 ULK1 IL6 TGFB1 BCL2 WNT16 15Q25 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5408%HOMO SAPIENS 15q25 copy number variation DNM3 SPCS2 SPCS1 SYNJ1 ALPK3 SHANK3 ZSCAN2 SHANK1 AGAP2 RYR2 AP3D1 SPCS3 RAF1 RYR1 SH3GL3 RAMAC ZNF592 RNMT BNC1 TENT4B BTBD1 GOLGA6L4 ADAMTSL3 C15orf40 FSD2 AP3S1 HTT WHAMM PDE8A SEC11A NMB EGF HOMER2 NMBR WDR73 AP3B2 GLYCOLYSIS IN SENESCENCE%WIKIPATHWAYS_20260810%WP5049%HOMO SAPIENS Glycolysis in senescence RB1 HEL-S-162eP HEL-S-133P ENO1 PRKAA1 HEL-S-68p HEL-S-30 ALA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260810%WP5136%HOMO SAPIENS ALA oxylipin metabolism ALOX5 EPHX2 ALOX15 HIPPO SIGNALING REGULATION%WIKIPATHWAYS_20260810%WP4540%HOMO SAPIENS Hippo signaling regulation LEF1 PRKCZ FGFR2 GNAL CDC42 TCF7L2 TCF7L1 PDGFRA CDH18 FLT1 IGF1R PRKAA2 CDH2 NTRK2 EGFR PRKACG GNAS PRKAR1A FGFR1 CDH8 CDH6 PRKAA1 GNA11 WWTR1 KDR PRKAB2 MTOR PRKAG1 PRKAG2 FLT3 RAC1 CSF1R FLT4 PRKAB1 CDH9 PRKAG3 PRKCA GNAI3 CDH4 YAP1 CDH10 CDH11 SMAD2 TEAD2 CDH12 TEAD3 TEAD4 LATS1 PRKAR1B CDH15 CDH16 PRKCB PLCB3 PLCB4 CDH17 NF2 LATS2 CDH19 ARHA EPHA2 PRKCI PLCB1 CDH24 PRKCH PLCB2 PRKCE NTRK1 NGFR KIT INSR FGFR4 FGFR3 PRKD3 PRKCQ CHRONIC HYPERGLYCEMIA IMPAIRMENT OF NEURON FUNCTION%WIKIPATHWAYS_20260810%WP5283%HOMO SAPIENS Chronic hyperglycemia impairment of neuron function PRKCZ NOS2 MMP9 SNAP25 SCN9A TRPA1 HEL-S-62p SORD TRPV1 SCN10A SCN8A MMP28 PRKCA MMP21 MMP20 MMP25 MMP24 AGER MMP27 MMP10 MMP12 MMP11 MMP16 MMP15 MMP23B MMP17 PRKCB MMP19 MMP14 MMP2 PRKCI MMP3 MMP7 PRKCH SLC2A3 PRKCE PRKD3 PRKCQ BDNF BLOOD CLOTTING CASCADE%WIKIPATHWAYS_20260810%WP272%HOMO SAPIENS Blood clotting cascade KLKB1 F2 FGA SERPINB2 F10 F11 SERPINF2 VWF PLAT F13B PLG F3 HEL-S-78p F5 F7 F8 F9 KLK1 P38 MAPK SIGNALING%WIKIPATHWAYS_20260810%WP400%HOMO SAPIENS p38 MAPK signaling TGFBR1 HRAS CDC42 STAT1 DDIT3 RAC1 RIPK1 MAP2K6 MAP3K5 RASGRF1 MEF2D MAPK14 HMGN1 MAPKAPK5 SMIM40 RPS6KA5 MYC TRADD HEL-S-102 ATF2 TRAF2 SHC1 MAX MAPKAPK2 MAP3K7 MAP2K4 CREB1 MAP3K1 GRB2 SARS COV 2 ALTERING ANGIOGENESIS VIA NRP1%WIKIPATHWAYS_20260810%WP5065%HOMO SAPIENS SARS CoV 2 altering angiogenesis via NRP1 ACE2 KDR VEGFA NRP1 FURIN CIRCADIAN RHYTHM GENES%WIKIPATHWAYS_20260810%WP3594%HOMO SAPIENS Circadian rhythm genes GFPT1 TPH2 PHLPP1 NLGN1 NR1H3 CHRM1 NR1C1 FBXW11 NONO PRKAA2 TNFRSF11A RELB CREB1 BTRC SKP1 NPAS2 NTRK3 PRKAA1 BHLHE41 RORB RORA CHRNB2 SFTPC LEP SLC9A3 EP300 TPH1 hCG_2014051 ATF4 CREM BHLHB2 SIRT1 IL6 NAMPT MTTP TOP2A NR1D2 PER2 PER1 KLF9 CRY2 CRY1 PTEN F7 AVP C1orf51 DDC CRTC1 NPY2R PRF1 UBC RORC UBE3A AHR RPS27A CCAR2 GIG8 PROK2 AgRP CPT1A EGR1 PROK1 HDAC2 UTS2R HTR7 KCNH7 HDAC3 USP2 METTL3 MAGED1 DYRK1A HDAC1 SOX14 CSNK1D PPARGC1A CARTPT MTNR1A TYMS CLDN4 MTNR1B PSPC1 TIMELESS UTS2 STAR SIK1 DRD2 ATF5 DDX5 MAGEL2 KMT2A RAI1 ADCY1 NKX2-1 DRD1 DRD3 DRD4 ZFHX3 TCF2 OPN4 JUND NOS2 OPN3 HOMER1 NR1D1 BTBD9 NR2F6 GNA11 SETX MAPK9 ID4 HNRNPD ID3 FBXL3 PRKDC ADA EZH2 KDM5A SUV39H2 MAPK10 SUV39H1 JUN HEBP1 RBM4 ADORA2A DBP SIN3A PPP1CC AANAT SIX3 HEL-S-2 PML TH KLF10 KCND2 HEL-S-80p PAX4 PROX1 MC3R SFPQ NCOR1 CDK4 THRAP3 KCNMA1 GSK3B CRH ROCK2 CIPC CRX RBM4B NPS ATOH7 MAPK8 PROKR1 OGT NFIL3 NOCT ARNT2 CAVIN3 PPARG PASD1 HCRTR2 NTRK1 HS3ST2 HCRTR1 NGFR PER3 MYBBP1A GHRH GHRL BMAL2 IMATINIB AND CHRONIC MYELOID LEUKEMIA%WIKIPATHWAYS_20260810%WP3640%HOMO SAPIENS Imatinib and chronic myeloid leukemia BCR FLT1 LYL1 CDKN1B PIM1 SKP2 PIM2 ABCG2 MYC FOXO3A CSF1R PDGFRA KIT GADD45A ABCB1 NOP2 GAB2 PRADER WILLI AND ANGELMAN SYNDROME%WIKIPATHWAYS_20260810%WP3998%HOMO SAPIENS Prader Willi and Angelman syndrome GABRB3 HEL-S-71 PCSK1 CYFIP1 PRKCZ AHCTF1 NUP188 FMR1 OXT NPAP1 GABRR3 PCM1 GABRR1 HERC2 DKFZp781B1423 BBS4 NUP214 NDC1 GOLGA8S GABRA5 SNRPN NUP210 NUP133 GOLGA6L2 NIPA1 TACR3 GABRG3 NIPA2 GABRG1 NUP93 NGF FEZ1 FEZ2 SNURF NUP54 POM121 NUP98 NUP58 OCA2 NUP205 SLC45A2 SEH1L LHB RNF8 UBE3A ATP10A AAAS NUP160 NHLH2 NUP42 NUP85 CDKN2B CCND1 TPR CDKN2C NDN NUP88 CGA CDKN2A NUP62 RAE1 RANBP2 NUP155 NUP153 CDC6 TYR KISS1 POMC TUBGCP5 TUBGCP6 NUP35 MKRN3 GNRH1 TUBGCP4 RB1 MAGEL2 CCND2 FSHB DLX5 EIF4E MSX1 INS CDK6 CDK4 MDM2 GHRH GHRL NUP107 BDNF INTRAFLAGELLAR TRANSPORT PROTEINS BINDING TO DYNEIN%WIKIPATHWAYS_20260810%WP4532%HOMO SAPIENS Intraflagellar transport proteins binding to dynein DYNC2I2 DYNC1H1 DYNLT1 IFT140 DYNLT3 DYNLT2B IFT80 DYNLL2 WDR35 DYNC2LI1 DYNC1LI1 IFT22 DYNC1LI2 IFT43 IFT81 IFT27 DYNLRB2 DNCL1 IFT46 DYNC1I1 IFT25 DYNC2H1 GENE REGULATORY NETWORK MODELING SOMITOGENESIS %WIKIPATHWAYS_20260810%WP2854%HOMO SAPIENS Gene regulatory network modeling somitogenesis FGF8 MESP2 HES7 LFNG EPHA4 HES1 NOTCH1 RIPPLY2 WNT3A TBX6 APOPTOSIS RELATED NETWORK DUE TO ALTERED NOTCH3 IN OVARIAN CANCER%WIKIPATHWAYS_20260810%WP2864%HOMO SAPIENS Apoptosis related network due to altered Notch3 in ovarian cancer NFKB1 CDKN1B RIPK2 JUND APP TNF HEL-S-89n BIRC5 ERN1 SQSTM1 PTK2B MAPK1 YBX3 BEX3 CUL5 RNF7 HEL-S-7 F2R TNFRSF10B IER3 VAV3 NQO1 HELLS HEL113 TRAF1 THBS1 NET1 GCLC CARD14 TNFRSF21 HSPD1 RPS6KB1 HEL-S-102 ERBB3 IL7R CTNNA1 PKN1 HDAC1 SOCS3 AXIN1 CDKN1A APOE NRG1 NSP1 FROM SARS COV 2 INHIBITS TRANSLATION INITIATION IN THE HOST CELL%WIKIPATHWAYS_20260810%WP5027%HOMO SAPIENS nsp1 from SARS CoV 2 inhibits translation initiation in the host cell EIF1AX EIF2S2 EIF2S1 SUI1 EIF3S3 EIF5 EIF2S3 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B TRIACYLGLYCERIDE SYNTHESIS%WIKIPATHWAYS_20260810%WP325%HOMO SAPIENS Triacylglyceride synthesis AGPAT4 GPAM PNPLA2 MOGAT3 GNPAT LIPE GPD1 AGPAT5 DGAT2 MOGAT2 MOGAT1 LPL AGPAT3 DGAT1 LIPF LIPC PLPP3 PLPP2 PLPP1 EPAC1 AND PKA REDUCTION OF RETINAL INFLAMMATION%WIKIPATHWAYS_20260810%WP5440%HOMO SAPIENS EPAC1 and PKA reduction of retinal inflammation IL1B NLRP3 PRKAR1A PRKAR1B METHIONINE DE NOVO AND SALVAGE PATHWAY%WIKIPATHWAYS_20260810%WP3580%HOMO SAPIENS Methionine de novo and salvage pathway AMD1 HEL-S-61p APIP MRI1 TXN SRM IL4I1 MSRA MTAP ADI1 CHDH SMS MSRB2 MSRB3 ENOPH1 MTR MAT1A INTERLEUKIN 1 INDUCED ACTIVATION OF NF KB%WIKIPATHWAYS_20260810%WP3656%HOMO SAPIENS Interleukin 1 induced activation of NF kB TRAF6 TIFA SQSTM1 NFKB1 HEL-S-71 IL1A PRKCZ IRAK1 AJUBA UBE2V1 16P13 11 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260810%WP5502%HOMO SAPIENS 16p13 11 copy number variation syndrome PAFAH1B1 PCM1 DCTN6 DCTN1 PLAG1 DCTN4 ACTR1B PLAGL1 KIAA0753 CEP170 BMERB1 DISC1 OFD1 ABCC1 NDE1 PLK1 ABCC6 MARF1 DCP1A CEP20 ACTR10 DCP2 RAPGEF4 RAP1A GATA3 15Q13 3 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4942%HOMO SAPIENS 15q13 3 copy number variation syndrome KAT2B GOLGA8R ARHGAP11B KLF13 OTUD7A GPR75 GOLGA8O GOLGA8Q TRPM1 GRM6 GOLGA8H CHRFAM7A CHRNA7 FAN1 CCL5 MTMR10 FANCD2 CREBBP FYN CALCIUM MEDIATED T CELL APOPTOSIS INVOLVED IN INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260810%WP5142%HOMO SAPIENS Calcium mediated T cell apoptosis involved in inclusion body myositis MEF2D CALM1 EP300 PPP3CA HDAC2 ITPRIP PPP3CC ATP2A1 CABIN1 HDAC1 CD8B ZAP70 CD8A LCK PLCG1 NFATC2 MODULATORS OF TCR SIGNALING AND T CELL ACTIVATION%WIKIPATHWAYS_20260810%WP5072%HOMO SAPIENS Modulators of TCR signaling and T cell activation LAT MAP3K8 NFKB1 MAP3K14 VAV1 SOCS1 DGKZ NFKBIA MEF2D TNFAIP3 CD8A ITK REL DGKA PLCG1 TMEM222 ARIH2 UBASH3A RASA2 NDUFB10 RPRD1B SH2B3 SH2D1A ARHH FIBP TRAF6 GNA13 CD5 CDKN1B AGO1 RELA PIK3R2 PIK3R1 CUL5 PTPN6 RNF7 CD3G IKBKB CD3E CD3D GRAP2 IKBKG ZAP70 MAP4K1 LCK LCP2 CARD11 CHUK BCL10 PDPK1 GRB2 PRKCQ CONTROL OF IMMUNE TOLERANCE BY VASOACTIVE INTESTINAL PEPTIDE%WIKIPATHWAYS_20260810%WP4484%HOMO SAPIENS Control of immune tolerance by vasoactive intestinal peptide IL12A IL5 CTLA4 IL4 VIP IL2 IFNG IL10 TGFB1 CD80 COHESIN COMPLEX CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260810%WP5117%HOMO SAPIENS Cohesin complex Cornelia de Lange syndrome AURKB CDCA5 PDS5B PDS5A SMC3 NIPBL APC PPP2CA SGOL1 PTTG1 RAD21 WAPAL ESCO1 PTPA ESCO2 PPP2R1B SMC1A REC8 SMC1B MAU2 STAG2 STAG3 ESPL1 PLK1 CDC2 PPP2R5E PPP2R1A HDAC8 PPP2R5B PPP2R5A PPP2R5D PPP2R5C FRAGILE X SYNDROME%WIKIPATHWAYS_20260810%WP4549%HOMO SAPIENS Fragile X syndrome GABRB2 CYFIP1 ABAT AP2A1 SHANK1 FMR1 GPHN MMP9 AP2S1 AP2M1 SOS1 CLTB GAD1 PTEN AKT1S1 CAMK2A NTRK2 CPT1A GRIN1 CDKN2A SHC1 MLST8 PLCG1 CREB1 PPP2R5B PRKAR1A GRIN2B EIF4G1 SRC MAP2K1 AGAP2 RHEB MAP2K2 APP HOMER1 CAMK4 MAP1B TSC2 TSC1 MTOR MAPK1 CYFIP2 RAF1 FYN ABCD3 EIF4E KCNC1 CLTC EPHA4 CLTA GRIP1 SYNGAP1 DLGAP3 DKFZp762B153 SH3GL1 PRKCA ALDH5A1 DUSP3 PTPN11 DEPTOR DICER1 KCND2 GRIP2 EIF4A1 TTI1 RPTOR EEF1A1 ALDH3A2 ARC TBC1D7 DAG1 PICK1 ARAF GRIA2 AKAP5 RAP1GAP CNR1 CLTCL1 RPS6KB1 SH3GL3 EIF4EBP2 PPP3CA EPS8L1 TARBP2 ARHGAP32 DLG4 AGO2 NF1 PLCB1 CAMK1 PTPN5 HCN1 BRAF GRB2 BDNF PAFAH1B1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5409%HOMO SAPIENS PAFAH1B1 copy number variation PAFAH1B1 DYNC1H1 NUDC HEL-S-303 VLDLR RELN NDEL1 TUBA1A METABOLISM OF DICHLOROETHYLENE BY CYP450%WIKIPATHWAYS_20260810%WP3666%HOMO SAPIENS Metabolism of dichloroethylene by CYP450 CYP2E1 ALZHEIMER 39 S DISEASE AND MIRNA EFFECTS%WIKIPATHWAYS_20260810%WP2059%HOMO SAPIENS Alzheimer 39 s disease and miRNA effects PSMD7 PSMD4 NFKB1 PSMD2 PSMD3 TNFRSF1A PSMD1 CSNK2A3 CSNK2A2 ATG14 CALM1 DKK2 DKK4 SFRP4 CSNK2B ULK2 APH1B NRBF2 ATG2A ATG2B RYR3 TUBA1C TUBA1B SNCA PSENEN APC2 IRS4 TUBB TUBB2A PSMA2 KNS2 PSMA8 PSMB6 TUBA3E PSMB2 PSMB3 CSNK1A1 TUBB4B TUBB4A PSMC6 PSMC4 RTN4 PSMC1 CDK5R1 HEL-S-276 TUBB8 TUBB6 KIF5A TUBB1 TUBA4A ADAM17 PPIF RTN3 PSMD12 PSMD13 PSEN2 ITPR2 GPR83 CACNA1C PSEN1 CACNA1F KLC4 ATP2A2 KLC3 KLC2 NAE1 TUBA1A CACNA1S SHFM1 TUBA2 TUBA8 WIPI1 WIPI2 SLC25A5 SLC25A6 TUBAL3 HEL-S-91n BECN2 HSD17B10 XBP1 ADRM1 SLC25A31 CSNK1A1L BACE1 APP ERN1 DDIT3 RB1CC1 WNT2B CSF1 IRS1 INS AMBRA1 ATG101 HEL-S-162eP WNT1 CSNK2A1 WNT3A WNT7B CHRNA7 PPP3CC DKK1 IL6 APC PIK3R4 FADD SLC25A4 GRIN1 NOX4 CASP8 IL1B EIF2AK2 NOS2 RELA MAPK9 MAPK10 CDK5 INSR PPP3R1 PPP3R2 PTGS2 CASP9 MAP2K1 MAP2K2 PIK3CD PIK3R3 PIK3R2 PIK3R1 MTOR MAPK1 RAF1 MAP3K5 MAPK3 ARAF AKT3 EIF2S1 FZD10 hCG_2014051 PLCB3 FRAT1 PLCB4 VDAC3 ATF4 PLCB1 PLCB2 WNT5B BRAF AXIN1 AXIN2 LPL CYCS WNT16 APOE CASP12 LRP5 PSMA4 HRAS APAF1 LRP6 DVL1 DVL2 DVL3 WNT3 WNT4 FZD1 WNT10B WNT10A FZD3 NRAS FZD2 BAD FZD7 FZD9 WNT7A ADAM10 ATP2A1 GRIN2B TNF HEL-S-61 CASP3 CYBB FZD5 AGER FZD8 IL1A GSK3B IKBKB PPP3CA MME MAPK8 TRAF2 ULK1 CALML6 CHUK CALML3 CALML4 PSMD9 PSMD6 FRAT2 EMBRYONIC STEM CELL PLURIPOTENCY PATHWAYS%WIKIPATHWAYS_20260810%WP3931%HOMO SAPIENS Embryonic stem cell pluripotency pathways FGFR2 STAT3 FGF3 JAK1 FGF6 PDGFRA FGF9 FGF23 FGF20 FGF22 FGF17 FGF16 FGF14 EGFR FGF21 FGF18 FGF13 FGF12 SMAD4 MAP2K3 MAP2K1 ACVR1 MAP2K2 HNF1A PIK3CD SELENOP LIF ACTR2 PIK3R2 ERAS MTOR MAPK1 FGF7 RAF1 MAP2K6 WNT2B PDGFA FGF4 FGF19 FGF8 MAPK6 MAPK4 ACVR2B WNT1 ARAF AKT3 WNT3A WNT7B NOG BMP4 WNT5B BRAF AXIN1 WNT9B FGF10 GRB2 WNT16 LRP5 HRAS LRP6 APC DVL1 DVL2 DVL3 WNT3 WNT4 FZD1 SOS1 WNT10B WNT10A FZD3 FZD2 FZD7 PTEN FZD9 WNT7A SMAD6 DKFZp781O1323 SMAD1 SMAD9 IL6ST FOS FGFR1 MAPK12 JUN FZD5 PTPN11 FZD4 FZD8 MDM2 GSK3B FGF2 MAPK7 BMPR1A MAP2K5 EGF FGFR4 FGFR3 GPCRS OTHER%WIKIPATHWAYS_20260810%WP117%HOMO SAPIENS GPCRs other HTR1F OR2F1 GPR55 EMR3 ADGRD1 GPR143 GPR183 OR2A5 LGR6 OR2A4 GPR18 OR7E24 HTR2A SSTR2 F2R IL8RB ADRB2 UTS2R HTR7 GPR83 CELSR2 ALG6 DRD3 DRD4 FSHR CHRM3 OR1G1 P2RY13 OR2M4 GPR61 P2RY11 ADRA1D GPR62 CELSR1 GRPR CELSR3 RXFP3 CHRM2 EDNRA ADORA2A GPR176 GPR132 GNRHR CCR5 GPR135 ADGRV1 S1PR1 CCR2 OR1F1 OR2H1 TAAR5 GHRHR OR1J2 CXCR1 TAAR2 OR1N1 GPR162 OR1R1 ADGRL2 CCKBR ADGRL3 SMO CNR1 OR5AC2 ADGRF5 VN1R1 OR10A2 OR6C3 OR3A3 OR6C2 OR10A5 OR3A1 OR8G1 PTGFR OR1E1 C5AR2 GPR88 GPR84 MCHR2 CXCR3 OR2B6 NTSR1 OR5D3 GPR17 NEUROINFLAMMATION%WIKIPATHWAYS_20260810%WP4919%HOMO SAPIENS Neuroinflammation MAPK14 NOS2 TLR4 ASCC1 COX2 RELA MAPK8 MTOR JUN CHUK FOS COX1 NFKBIA VITAMIN D SENSITIVE CALCIUM SIGNALING IN DEPRESSION%WIKIPATHWAYS_20260810%WP4698%HOMO SAPIENS Vitamin D sensitive calcium signaling in depression GRIN2B TPH2 KDM3A KDM1A KDM1B SLC8A1 CALB1 ATP2B4 NR1i1 ATP2B3 CYP27A1 CHRM1 ATP2B2 CYP27B1 ATP2B1 HEL-75 RXRA KCNQ2 KCNQ3 PVALB KDM6B NFE2L2 GCLC TPH1 GRIN1 ITPR2 CACNA1C BCL2 ASPIRIN AND MIRNAS%WIKIPATHWAYS_20260810%WP4707%HOMO SAPIENS Aspirin and miRNAs NFKB1 VEGFA PTGS1 NR1C1 WNT1 MVD PTGS2 IL7 SIGNALING%WIKIPATHWAYS_20260810%WP205%HOMO SAPIENS IL7 signaling JAK3 GSK3B MAP2K1 MAP2K2 STAT1 STAT3 PIK3R2 PIK3R1 IL7R STAT5B PTK2B MAPK1 BAD FYN JAK1 IL7 MAPK3 IL2RG RAS SIGNALING%WIKIPATHWAYS_20260810%WP4223%HOMO SAPIENS Ras signaling GNGT1 NFKB1 GNGT2 CALM1 FGFR2 CDC42 PAK1 TIAM1 RALBP1 RALA RAC3 EXOC2 PDGFRA PLA2G1B EGFR GNB2 RAP1A GNB1 PRKACG GNB4 PLCG2 PLCE1 REL PLCG1 STK4 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 BCL2L1 MAP2K1 MAP2K2 PIK3CD PIK3R3 PIK3R2 PIK3R1 PLA1A MAPK1 RAF1 CSF1R MAPK3 AFDN AKT3 PRKCB ARHA ZAP70 TNFSF6 KIT GRB2 LAT HRAS GNB3 RALB PLD2 SOS1 SOS2 NRAS BAD ETS2 RASSF1 PLA2G10 RIN1 SHC4 RASGRF1 RAB5B SHC2 FLT1 RAB5C SHC3 PLA2G3 RASAL1 FOXO4 IGF1R RASAL3 RASGRP4 TTBK1 RASGRP3 NTRK2 RRAS ABL2 GNB5 GRIN1 RGL2 RAB5A HTR7 RASGRF2 SHC1 PLA2G12A PLA2G4F RASA4B PLA2G12B PLA2G4D KSR1 PLA2G4E PLA2G4C RRAS2 PLAAT3 RASA2 KSR2 FGFR1 RASA3 RASA4 RAPGEF5 ARF6 SHOC2 PLA2G2F PLA2G2D GRIN2B PLA2G2E PLA2G2C PLA2G4B RELA MAPK9 PLA2G5 KDR PLA2G6 FLT3 RAC1 FLT4 MAPK10 SYNGAP1 PRKCA PTPN11 IKBKB MAPK8 EPHA2 IKBKG NF1 PAK6 PAK4 NTRK1 NGFR GNG10 INSR CALML6 CHUK CALML3 CALML4 GNG12 FGFR4 GNG11 FGFR3 PLA2G2A GNG13 GAB2 MESODERMAL COMMITMENT PATHWAY%WIKIPATHWAYS_20260810%WP2857%HOMO SAPIENS Mesodermal commitment pathway CCDC6 MIXL1 TOX3 FOXA1 TCF7L1 FOXA2 CCND1 SMAD4 PRKAR1A ACVR1 HAND1 HES7 CUL4B NFE2L2 ZIC5 TBX6 BMP7 VAV3 FGF8 YAP1 SNAI1 ACVR2B TCF4 TEAD2 LEFTY1 WNT3A LATS1 NOG INHBA DKK1 BHLHB2 GATA3 BMP4 AXIN1 AXIN2 NODAL POU5F1 CTBP2 PBX1 LEF1 PPP2CA WNT3 SMAD6 CRTC1 PLCH1 KLF4 ACACA SMAD1 HTT FOXC2 FOXC1 FGFR1 SOX2 SOX21 SOX17 TRIM28 CEP250 SESN1 RPL38 PITX2 WDHD1 FOXH1 ARID5B GATA6 EMSY PIAS1 NLK ADAM19 TWSG1 WDFY2 BCORL1 TOX MBTD1 EPB41L5 UBR5 ATP8B2 PBX3 HMGA2 GDF3 EXT1 EXT2 FZD5 NABP2 TRIM71 BCAR2 FZD4 SETD2 PHF6 CSRP2 FZD8 ZIC2 ZIC3 TRIM5 SMAD2 ZFHX4 C1QBP HNF4A DNMT3B JARID2 AMH SLC2A12 MSGN1 TET1 PARP8 NR1B3 BMPR1A ARL4A AEBP2 SCHIP1 RARB AHDC1 C9orf72 WDCP LEFTY2 TBX1 ZNF462 ELP4 ACVR2A TBX3 MEIS1 KLF5 RGS10 ESTROGEN RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2881%HOMO SAPIENS Estrogen receptor pathway CYP1A1 ACOX1 CYP1B1 SP1 CYP1A2 GPAM PDK4 PCK1 NR1C1 JUN NR0B2 STAT3 INCLUSION BODY MYOSITIS%WIKIPATHWAYS_20260810%WP5120%HOMO SAPIENS Inclusion body myositis PSEN2 NFKB1 PSENEN SIRT1 PSEN1 BACE1 APP MSTN NFKB2 TRANS SULFURATION ONE CARBON METABOLISM AND RELATED PATHWAYS%WIKIPATHWAYS_20260810%WP2525%HOMO SAPIENS Trans sulfuration one carbon metabolism and related pathways HEL-S-61p AHCYL2 AHCYL1 SLC25A48 PSAT1 DNMT3L PHGDH HEL-S-64p CHDH GPX2 PSPH PCYT1B GPX1 GPX4 GPX3 BHMT2 GPX6 BCAT2 AMT GPX7 BAAT GAD1 MTHFD1 HEL-75 MTHFD2 MTHFD2L GAD2 BCAT1 HEL-S-75p PCYT2 SHMT1 HEL-S-51e CHKB MTHFD1L CBS pcap CHKA AGXT2 HEL-S-182mP HEL-S-44 CTH GCLM CDO1 PEMT CHPT1 CEPT1 MTR ALDH7A1 TYMS MAT1A DHFR GCLC DNMT3B ACQUIRED PARTIAL LIPODYSTROPHY BARRAQUER SIMONS SYNDROME%WIKIPATHWAYS_20260810%WP5104%HOMO SAPIENS Acquired partial lipodystrophy Barraquer Simons syndrome FNTA LMNA CFD RCE1 CFB ICMT HEL-S-62p LMNB2 6Q16 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5400%HOMO SAPIENS 6q16 copy number variation GHSR LEP NTRK2 MC4R NPY LEPR AgRP SIM1 POMC INSR GHRL INS BDNF CAFFEINE IN MYOCYTES%WIKIPATHWAYS_20260810%WP5603%HOMO SAPIENS Caffeine in myocytes PS1TP5BP1 MYL2 MYL3 TNNT3 MYH8 MYH6 RYR2 RYR3 ACTA2 RYR1 ACTG2 HEL-S-273 MYH13 ACTG1 MYL11 TNNI1 MYH1 TNNI2 MYH2 TNNI3 MYL6 HEL-S-108 TPM3 MYH4 MYH7 TNNC1 TPM1 TNNC2 ACTA1 MYL1 TNNT1 CARDIAC PROGENITOR DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2406%HOMO SAPIENS Cardiac progenitor differentiation SOX2 IRX4 IGF1 MYL2 IGF2 MIXL1 TBX5 ZFP42 MYH6 BMP1 SOX17 ROR2 ISL1 CXCR4 KDR SCN5A MESP2 NOTCH1 PDGFRA INS MAPK14 FOXA2 MEF2C GSK3B WNT3A FGF2 NOG LIN28A INHBA DKK1 TNNI3 BMP4 MESP1 GATA4 THY1 TGFB1 TBXT KIT MYLK3 NODAL SOX1 LIN28B TBX20 SIRPA POU5F1 NCAM1 NKX2-5 NRG1 MAPK CASCADE%WIKIPATHWAYS_20260810%WP422%HOMO SAPIENS MAPK cascade MAP3K2 LAMTOR3 HRAS SIPA1 MAP2K3 MAP2K1 MAP3K12 MAP2K2 SOS1 SOS2 NRAS MAPK1 MAPK12 RAF1 MAPK10 MAP2K6 MBP JUN MAPK3 MAPK14 ARAF RRAS PLCB3 BRAF MAP2K4 MAP2 MAP3K1 RASA3 GRB2 NONALCOHOLIC FATTY LIVER DISEASE%WIKIPATHWAYS_20260810%WP4396%HOMO SAPIENS Nonalcoholic fatty liver disease NFKB1 TNFRSF1A CDC42 NR1H3 COX2 COX7C CYB UQCRFS1 NR1C1 NDUFS8 UQCRC1 NDUFS3 COXFA4 UQCRC2 UQCRB GSK3A UQCR11 UQCR10 COX5A UQCRH ADIPOR2 CYC1 NDUFA9 CEBPA PRKAA2 UQCRQ LEPR NDUFA13 NDUFA11 XBP1 NDUFA12 NDUFA10 PRKAA1 COX6A2 COXFA4L2 PIK3CD NDUFC2-KCTD14 PIK3R3 SDHC BBC3 SDHD SDHA PIK3R2 COX6B2 ERN1 PIK3R1 SDHB BCL2L11 PRKAB2 COX7A2L NDUFB11 PRKAG1 DDIT3 COX7A2 PRKAG2 ADIPOR1 NDUFV3 NDUFV2 MAP3K11 RXRA PRKAB1 COX7B2 MAP3K5 MLXIPL PRKAG3 MLX COX8C NDUFC2 IRS1 NDUFC1 INS NDUFS6 NDUFS5 NDUFS4 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 AKT3 IL6R NDUFB4 NDUFB3 EIF2S1 NDUFB2 LEP NDUFB1 MLXIP NDUFA7 NDUFA6 NDUFA5 PKLR ATF4 ZNF183 NDUFA3 NDUFA2 NR1H4 UQCRHL ITCH IL6 NDUFAB1 TNFSF6 CYCS BAK1 COX7B COX6A1 BAX COX8A COX6B1 CXCL8 CASP8 SOCS3 COX7A1 COX3 COX1 NDUFB10 IL1B CYP2E1 TNF COX4I2 RELA MAPK9 CASP3 CCL2 RAC1 JUN VCAM1 IL1A GSK3B IKBKB MAPK8 TRAF2 TGFB1 INSR PROTEASOME DEGRADATION%WIKIPATHWAYS_20260810%WP183%HOMO SAPIENS Proteasome degradation PSMD7 UBE2B H2AX PSMD4 HLA-B PSMD2 HLA-C PSMD3 HLA-A HEL-S-91n PSMD1 HLA-F HLA-G PSMA4 PSMB8 UBE2D1 HLA-E PSMB9 HEL-S-283 PSME2 HEL-117 HIST1H2AB IFNG PSMA2 NEDD4 PSMB6 PSMB2 PSMB3 PSMC6 PSMC4 PSMC1 UBB HEL-S-276 UBC H2AZ1 PSMD12 PSMD13 PSMD10 PSMD11 RPN2 UBA7 UBE2D2 UBE2D3 RPN1 PSMD9 PSMB10 PSMD6 PSMD5 SARS COV 2 REPLICATION ORGANELLE FORMATION%WIKIPATHWAYS_20260810%WP5156%HOMO SAPIENS SARS CoV 2 replication organelle formation PIK3R4 FOCAL ADHESION%WIKIPATHWAYS_20260810%WP306%HOMO SAPIENS Focal adhesion IGF1 RELN VEGFB CDC42 PAK1 VEGFC VEGFD VAV1 VAV2 RAC3 COMP PDGFRA IBSP TNR ITGB3 COL4A6 ITGAV CHAD EGFR CCND1 RAP1A MYL11 ERBB2 VWF BIRC2 BIRC3 MYLK3 THBS4 MAP2K1 COL2A1 PIK3CD PIK3R3 PIK3R2 PIK3R1 MAPK1 RAF1 MAPK3 PDGFA VAV3 ROCK1 LAMA1 AKT3 LAMA3 LAMC2 LAMB3 LAMB1 HGF PRKCB ACTG1 ARHA VEGFA BRAF BCL2 GRB2 CAV3 MYL2 HRAS MYLK2 sm-M20 ARHGAP35 MYLK SOS1 MYLK4 ACTN1 MYL5 MYL7 TLN2 BLK BAD TXK MYL12A PTEN MYL12B TNC MYL10 VASP SRMS CAV2 LAMB2 TNK2 LAMA4 TNK1 SHC4 PTK6 ITGB1 RASGRF1 ITGA1 PARVB XB SHC2 PARVG FLT1 LAMC1 ARHGAP5 THBS2 SHC3 EMP2 THBS1 PIP5K1C RAPGEF1 COL1A2 PPP1R12C COL4A2 DOCK1 IGF1R COL4A1 FLNA CRKL COL5A3 FLNB c-fgr COL5A2 ZYX ITGB6 SHC1 opn PS1TP5BP1 THBS3 CCND3 SRC CCND2 ITGB4 MAPK9 KDR FYN RAC1 MAPK10 ITGA2B JUN PPP1CC PRKCA ITGB8 HEL-S-80p ITGB7 HEL114 COL1A1 ITGA4 ITGA2 GSK3B ITGA7 ROCK2 ITGA6 MAPK8 ACTN4 HEL-S-28 CRK COL4A4 PXN PAK6 PAK4 TLN1 PDGFD PDGFC LAMA5 EGF PDPK1 VTN PARVA ALZHEIMER 39 S DISEASE%WIKIPATHWAYS_20260810%WP5124%HOMO SAPIENS Alzheimer 39 s disease PSMD7 PSMD4 NFKB1 PSMD2 PSMD3 TNFRSF1A PSMD1 CSNK2A3 CSNK2A2 ATG14 CALM1 DKK2 DKK4 SFRP4 CSNK2B ULK2 APH1B NRBF2 ATG2A ATG2B RYR3 TUBA1C TUBA1B SNCA PSENEN APC2 IRS4 TUBB TUBB2A PSMA2 KNS2 PSMA8 PSMB6 TUBA3E PSMB2 PSMB3 CSNK1A1 TUBB4B TUBB4A PSMC6 PSMC4 RTN4 PSMC1 CDK5R1 HEL-S-276 TUBB8 TUBB6 KIF5A TUBB1 TUBA4A ADAM17 PPIF RTN3 PSMD12 PSMD13 PSEN2 ITPR2 GPR83 CACNA1C PSEN1 CACNA1F KLC4 ATP2A2 KLC3 KLC2 NAE1 TUBA1A CACNA1S SHFM1 TUBA2 TUBA8 WIPI1 WIPI2 SLC25A5 SLC25A6 TUBAL3 HEL-S-91n BECN2 HSD17B10 XBP1 ADRM1 SLC25A31 CSNK1A1L BACE1 APP ERN1 DDIT3 RB1CC1 WNT2B CSF1 IRS1 INS AMBRA1 ATG101 HEL-S-162eP WNT1 CSNK2A1 WNT3A WNT7B CHRNA7 PPP3CC DKK1 IL6 APC PIK3R4 FADD SLC25A4 GRIN1 NOX4 CASP8 IL1B EIF2AK2 NOS2 RELA MAPK9 MAPK10 CDK5 INSR PPP3R1 PPP3R2 PTGS2 CASP9 MAP2K1 MAP2K2 PIK3CD PIK3R3 PIK3R2 PIK3R1 MTOR MAPK1 RAF1 MAP3K5 MAPK3 ARAF AKT3 EIF2S1 FZD10 hCG_2014051 PLCB3 FRAT1 PLCB4 VDAC3 ATF4 PLCB1 PLCB2 WNT5B BRAF AXIN1 AXIN2 LPL CYCS WNT16 APOE CASP12 LRP5 PSMA4 HRAS APAF1 LRP6 DVL1 DVL2 DVL3 WNT3 WNT4 FZD1 WNT10B WNT10A FZD3 NRAS FZD2 BAD FZD7 FZD9 WNT7A ADAM10 ATP2A1 GRIN2B TNF HEL-S-61 CASP3 CYBB FZD5 AGER FZD8 IL1A GSK3B IKBKB PPP3CA MME MAPK8 TRAF2 ULK1 CALML6 CHUK CALML3 CALML4 PSMD9 PSMD6 FRAT2 CCL18 SIGNALING%WIKIPATHWAYS_20260810%WP5097%HOMO SAPIENS CCL18 signaling MMP2 PTK2B CDH2 CCR8 AK4 ZEB2 GABA AND GLUTAMATE SIGNALLING IN EPILEPTOGENESIS%WIKIPATHWAYS_20260810%WP5600%HOMO SAPIENS GABA and glutamate signalling in epileptogenesis GABRR3 STAT1 STAT3 GABRR1 CAMK2A ERBB4 CREBBP ORAI1 MAP2K1 MAPK1 MAPK3 DKFZp762B153 EFNB2 HEL-S-162eP SLC1A3 PLCB1 SUMO1 GABRB3 GABRB2 GABRB1 ABAT AP2A1 AP2A2 PPP2CA GABRE GABRQ PDIA2 GABRA2 GABRP GABRA6 SLC32A1 GABRA5 GAD1 GABRA4 GABRA3 SLC6A11 GABRG3 GABRG1 CRTC1 CDH2 GRM6 FRMPD3 GRIN1 ADARB1 PIG59 SH3GL2 HDAC10 SLC6A13 SLC6A12 CABIN1 STIM1 HDAC1 SLC1A1 SLC1A2 GRIA3 GRIA4 NETO2 GRIN3B GRIN3A SLC6A8 CPEB3 GRIK5 GRIK3 GRIK1 SLC7A11 GRIK2 GRM3 GRIN2B GRM2 GRM8 NPTN FFAR1 SRC C1QL3 C1QL2 NRXN3 CACNG8 HOMER1 NWD1 SNX27 CACNG2 GNA11 ATAD1 MBD5 SLC12A5 SYVN1 LHFPL4 SNX14 SDCBP GRIP1 DLGAP3 PRKCA ARC PICK1 GRIA2 DLG4 GLS2 NRG1 HEMATOPOIETIC STEM CELL GENE REGULATION BY GABP ALPHA BETA COMPLEX%WIKIPATHWAYS_20260810%WP3657%HOMO SAPIENS Hematopoietic stem cell gene regulation by GABP alpha beta complex ETV6 BCL2L1 DNMT3B ATM EP300 FOXO3A CREBBP GABPB1 SMAD4 TERF2 FLT3 ZFX PTEN SMARCA4 GABPA MCL1 BCL2 INTERFERON SIGNALING IN TUBERCULOSIS%WIKIPATHWAYS_20260810%WP4197%HOMO SAPIENS Interferon signaling in tuberculosis IFNAR2 PSMB8 TYK2 STAT1 PIAS1 IRF-1 IFNAR1 IRF9 IFNG SOCS1 STAT2 JAK1 IFNGR1 IFITM1 IFNGR2 MX1 IFI35 IFIT1 IFIT3 13Q12 OR CRYL1 COPY NUMBER VARIATION %WIKIPATHWAYS_20260810%WP5405%HOMO SAPIENS 13q12 or CRYL1 copy number variation HEL30 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES AUTOPHAGY%WIKIPATHWAYS_20260810%WP4863%HOMO SAPIENS Host pathogen interaction of human coronaviruses autophagy ATG16L2 ATG16L1 DKFZp686F0183 ULK2 ATG12 MTOR MAP1LC3A ULK1 RB1CC1 PIK3R4 ATG3 ATG10 WIPI1 ZFYVE1 FELBAMATE METABOLISM%WIKIPATHWAYS_20260810%WP2816%HOMO SAPIENS Felbamate metabolism CYP2E1 CYP3A4 EGF EGFR SIGNALING%WIKIPATHWAYS_20260810%WP437%HOMO SAPIENS EGF EGFR signaling CDC42 STAT1 PAK1 STAT3 COX2 VAV1 VAV2 RALBP1 RALA JAK1 SPRY2 SP1 CAMK2A EGFR RAP1A ERBB2 PLCE1 PLCG1 PCNA CREB1 NDUFA13 FOXO1 PXDN ARHGEF1 MAP3K2 MAP2K1 MAP2K2 PIK3R2 PIK3R1 MTOR EIF4EBP1 MAPK1 RAF1 NEDD4 VAV3 GJA1 RICTOR RPS6KA5 RPS6KA2 ROCK1 MAPK4 RPS6KA1 MEF2C RPS6KB1 SH3GL3 PRKCB PRKCI STAT5B ITCH BRAF GRB2 SYNJ1 HEL-S-34 PRKCZ AP2A1 HRAS RALB PLD2 AP2S1 AP2M1 SOS1 SOS2 PTEN CAV2 TNK2 RIN1 PTK6 PIK3C2B MEF2D FOXO4 CRKL ATF1 RAB5A SH3GL2 SHC1 FOS NCK2 ARF6 SRC JUND HEL-S-15 MAPK9 INPP5D PTK2B RAC1 JUN PRKCA PTPN11 MAPK14 USP6NL INPPL1 CBLC GRB10 HGS STAMBP STAM2 STXBP1 NCK1 SH2D2A ATXN2 EPS15L1 EPN1 PLSCR1 ASAP1 MAPK8 NEDD8 MAPK7 CBL CRK REPS2 CSK LIMK2 FOSB PTPN5 MAP2K5 IQGAP1 MAP4K1 MAP3K1 EGF PDPK1 GAB2 SYNAPTIC VESICLE PATHWAY%WIKIPATHWAYS_20260810%WP2267%HOMO SAPIENS Synaptic vesicle pathway SLC17A8 DNM3 STX2 SLC18A1 SLC18A2 SLC18A3 UNC13B AP2A1 UNC13C AP2A2 UNC13A SYT1 AP2S1 SYP STX1A SYN2 SNAP25 AP2M1 SYN1 STX1B STX3A SLC32A1 SLC38A1 CLTC CLTA SLC25A4 VAMP2 STXBP1 CLTCL1 SLC1A3 NAPA SLC22A3 CACNA1B CACNA1A CPLX2 CLN8 CPLX1 HEL-S-67p RIMS1 SLC17A6 SLC17A7 FTO OBESITY VARIANT MECHANISM%WIKIPATHWAYS_20260810%WP3407%HOMO SAPIENS FTO obesity variant mechanism PRDM16 UCP1 PPARGC1A TBX1 ARID5B IRX5 IRX3 UNFOLDED PROTEIN RESPONSE%WIKIPATHWAYS_20260810%WP4925%HOMO SAPIENS Unfolded protein response IL1B PPP1R15A XBP1 EIF2S1 BBC3 HEL-S-89n ERN1 ATF4 MBTPS1 BCL2L11 RTCB CASP2 TXNIP DDIT3 PMAIP1 MBTPS2 BCL2 NFE2L2 TNFRSF10B GPR143 IN MELANOCYTES AND RETINAL PIGMENT EPITHELIUM CELLS%WIKIPATHWAYS_20260810%WP4941%HOMO SAPIENS GPR143 in melanocytes and retinal pigment epithelium cells GPR143 DCT PRKCB PLCB3 PLCB4 PRKACG GNAS VEGFA PLCB1 PMEL ADCY9 PLCB2 DKFZp686L0365 ASIP TYR TYRP1 CREB1 POMC GNA15 MC1R ANGIOTENSIN II RECEPTOR TYPE 1 PATHWAY%WIKIPATHWAYS_20260810%WP5036%HOMO SAPIENS Angiotensin II receptor type 1 pathway TGFBR1 AGTR1 COL1A1 SP1 COL1A2 IL11 JUND TGFBR2 RRAS CTGF NOX4 ACTA2 ACE2 MAPK1 SMAD4 RAF1 TGFB1 MAP2K6 IL11RA MAS1 PDGFD IL6ST HIF1A PTPN11 TGF BETA RECEPTOR SIGNALING IN SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260810%WP4816%HOMO SAPIENS TGF beta receptor signaling in skeletal dysplasias NFKB1 TGFBR1 LEF1 HRAS TGFBR2 STAT1 STAT3 JAK1 ZFYVE9 ADAMTSL2 RUNX2 TGIF1 SMAD6 TGFBR3 ENG LTBP1 ZNF423 pp6425 THBS1 FKBP1A SKI BAMBI DKFZp781O1323 ITGB6 ZEB2 CREBBP SMAD4 SMAD1 SMAD9 FOS opn TNF FOXH1 LIF MAPK9 IFNG JUN MAPK3 SKIL WNT1 SMAD2 LEFTY1 RUNX3 EP300 FST NOG INHBA BMP4 FBN1 LEFTY2 TGFB1 EGF FOLATE ALCOHOL AND CANCER PATHWAY HYPOTHESES%WIKIPATHWAYS_20260810%WP1589%HOMO SAPIENS Folate alcohol and cancer pathway hypotheses CYP2E1 MTR ADH5 CEBPB CREB1 HEL-S-53e CBS BLOOD BASED NEUROINFLAMMATION MARKERS %WIKIPATHWAYS_20260810%WP5548%HOMO SAPIENS Blood based neuroinflammation markers IL1B CRP PBR GRN CCL23 CCL11 ADM TNF S100B CX3CL1 OLR1 CHI3L1 TREM1 CCL5 NEFL CCL2 IL6 DBI BDNF GFAP AFLATOXIN B1 METABOLISM%WIKIPATHWAYS_20260810%WP699%HOMO SAPIENS Aflatoxin B1 metabolism EPHX1 GSTM1 CYP2A13 CYP1A2 CYP3A4 HEL-S-166mP COVID 19 STRUCTURAL COVERAGE MAP%WIKIPATHWAYS_20260810%WP5145%HOMO SAPIENS COVID 19 structural coverage map UBB UBC PARP14 NLRP12 ACE2 TOMM70 UPF2 NRP1 SLC6A19 AQR IGHMBP2 MACROH2A2 MAP3K7IP1 ISG15 GDAP2 MACROD1 HEL97 MACROD2 CMTR1 PAIP1 PALS1 T CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP69%HOMO SAPIENS T cell receptor signaling LAT MAP3K8 NFKB1 HRAS MAP3K14 CDC42 PAK1 VAV1 SOS1 NFKBIA CRKL ATF2 SHC1 CD8A ITK REL PLCG1 CREB1 FOS SH2B3 HEL-S-81p PSTPIP1 TRAF6 FYB1 RIPK2 MAP2K1 MAP2K2 RELA PIK3R2 MAPK9 PIK3R1 PTK2B MAPK1 RAF1 FYN JUN MAPK3 PTPN11 VAV3 MAPK14 NCK1 CD3G IKBKB CD3E CD3D MAPK8 CBL GRAP2 IKBKG CRK MAP3K7 ZAP70 WAS NFATC1 MAP4K1 LCK LCP2 CARD11 CHUK BCL10 PDPK1 ICOS GRB2 PRKCQ NFATC2 GAB2 ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY%WIKIPATHWAYS_20260810%WP2118%HOMO SAPIENS Arrhythmogenic right ventricular cardiomyopathy LEF1 RYR2 DMD CTNNA2 SLC8A1 ACTN1 TCF7L2 TCF7L1 ITGB3 ITGAV ITGB1 ITGA1 CDH2 ITGB6 CACNA1C CACNA1F ATP2A2 CACNA1S PS1TP5BP1 SGCD SGCA SGCB SGCG ITGB4 CACNA2D1 CACNA2D3 CACNA2D2 CACNA2D4 CACNG8 CACNB1 CACNB3 CACNB4 CACNG2 EMD PKP2 DSG2 DSC2 CACNG6 CACNG7 CTNNA3 CACNG1 CACNG3 CACNG4 CACNG5 ITGA2B JUP GJA1 ITGB8 ITGB7 ITGA4 ITGA2 DAG1 ITGA7 ITGA6 ACTN4 ACTG1 LMNA CTNNA1 ACTN2 DES HALLMARK OF CANCER NON MUTATIONAL EPIGENETIC REPROGRAMMING%WIKIPATHWAYS_20260810%WP5483%HOMO SAPIENS Hallmark of cancer non mutational epigenetic reprogramming PIP4K2A HDAC1 CREBBP EZH2 IFITM3 ANKRD13C CADM1 TET2 EP300 NOL9 IRS1 HDAC2 COLCHICINE METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP2536%HOMO SAPIENS Colchicine metabolic pathway CYP3A4 IRINOTECAN PATHWAY%WIKIPATHWAYS_20260810%WP229%HOMO SAPIENS Irinotecan pathway ABCC2 UGT1A1 CES2 UGT1A9 CES1 CYP3A4 ABCG2 ABCC1 UGT1A10 BCHE SLCO1B1 ARIPIPRAZOLE METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP2640%HOMO SAPIENS Aripiprazole metabolic pathway CYP3A43 RETT SYNDROME%WIKIPATHWAYS_20260810%WP4312%HOMO SAPIENS Rett syndrome GRIN2B SHANK3 SYNE2 GABBR2 SMC1A TBL1X SCN8A GNAO1 GABRA3 SMARCA4 SYNGAP1 EIF2B2 KDM5B TRRAP NCOR1 FOXG1 MEF2C TCF4 GPS2 STXBP1 CHD4 RHOBTB2 CECR2 TAF1B HDAC5 HIVEP2 SCN1A SRRM3 CDKL5 KCNJ10 ACTL6B CRK SMARCA1 HDAC1 NCOR2 XAB2 TBL1XR1 BRAF IMPDH2 HAP1 HTT HDAC8 SCN2A OSX AND MIRNAS IN TOOTH DEVELOPMENT%WIKIPATHWAYS_20260810%WP3971%HOMO SAPIENS OSX and miRNAs in tooth development ALPL HNF1A KLF4 NOTCH3 NOTCH4 DKK1 NOTCH2 NOTCH1 DMP1 SOST DSPP SP7 RUNX2 BMP7 INTRACELLULAR TRAFFICKING PROTEINS INVOLVED IN CMT NEUROPATHY%WIKIPATHWAYS_20260810%WP4856%HOMO SAPIENS Intracellular trafficking proteins involved in CMT neuropathy LITAF RAB11A FIG4 FGD4 SH3TC2 RAB25 PMP22 KIF1B SBF2 RABAC1 RAB7A HEL-S-102 MFN2 RAB11B NEFL MTMR2 EGR2 RAB3B LRSAM1 RAB4A MPZ RAB4B HSPB8 OLIGODENDROCYTE SPECIFICATION AND DIFFERENTIATION LEADING TO MYELIN COMPONENTS FOR CNS%WIKIPATHWAYS_20260810%WP4304%HOMO SAPIENS Oligodendrocyte specification and differentiation leading to myelin components for CNS IGF1 IL1B SOX9 SOX5 OLIG1 OLIG2 SOX10 CNP SOX8 TNF SOX6 NKX2-6 MOG LIF OMG MYT1 CNTF MBP BMP2 SHH CXCL1 ASCL1 FGF2 CXCL2 BMP4 NKX2-2 INSULIN SIGNALING%WIKIPATHWAYS_20260810%WP481%HOMO SAPIENS Insulin signaling GYS2 MAP3K14 PFKL IRS4 SOCS1 GSK3A PRKAA2 PTPN1 GYS1 FOXO1 MAP3K2 MAP2K3 XBP1 MAP2K1 MAP3K10 RHEB MAP3K12 PRKAA1 MAP2K2 PIK3CD SGK1 PIK3R3 TSC2 TSC1 PIK3R2 PIK3R1 MTOR EIF4EBP1 MAPK1 RAF1 EIF4E MAP3K11 TRIB3 MAP2K6 MAP3K5 MAPK3 IRS1 RPS6KA4 MAPK6 RPS6KA5 RPS6KA2 MAPK4 RPS6KA1 RPS6KB1 RPS6KB2 PRKCB PRKCI FOXO3A PRKCH GRB2 RAB4A PRKCQ MAP3K8 PRKCZ HRAS SNAP25 SOS1 RPS6KA6 SOS2 ENPP1 MAP3K6 GYG1 LIPE INPP4A STXBP3 STXBP4 RRAD PTEN PIK3R4 PPP1R3A KIF3A STX4A PIK3C2G EHD1 EHD2 MAP3K13 ARF1 HEL-S-31 SNAP23 SHC2 PTPRF FLOT1 VAMP2 SHC3 FLOT2 CAP1 RAPGEF1 MAP4K2 MINK1 IGF1R TBC1D4 SGK2 SNX26 MAP4K3 SH2B2 HEL-S-42 EGR1 MYO1C PFKM SHC1 SOCS3 FOS SLC2A4 ARF6 HEL-S-61 MAPK9 MAPK12 RAC1 MAPK13 MAPK10 JUN MAPK11 PRKCA PTPN11 MAPK14 INPPL1 CBLC GRB10 STXBP1 GSK3B GRB14 IKBKB MAPK8 MAPK7 CBL CRK MAP3K7 MAP2K5 MAP4K1 MAP2K4 INSR MAP3K1 PDPK1 BREAST CANCER PATHWAY%WIKIPATHWAYS_20260810%WP4262%HOMO SAPIENS Breast cancer pathway IGF1 CSNK2A3 CSNK2A2 SFRP4 CSNK2B APC2 FGF3 TCF7L1 FGF6 FGF9 CSNK1A1 FGF23 SP1 FGF20 FGF22 FGF17 FGF16 EGFR CCND1 FGF21 FGF18 ERBB2 SKP1 NR3A2 HEY2 PGR MAP2K1 CSNK1A1L MAP2K2 PIK3CD PIK3R3 E2F3 NOTCH3 PIK3R2 PIK3R1 NOTCH4 MTOR MAPK1 FGF7 RAF1 DLL3 DLL4 WNT2B NOTCH1 MAPK3 FGF4 FGF19 FGF8 TNFSF11 WNT1 ARAF AKT3 CSNK2A1 MYC WNT3A RPS6KB1 FZD10 WNT7B RPS6KB2 FRAT1 WNT5B BRAF AXIN1 AXIN2 KIT FGF10 GRB2 WNT16 CDKN1A LEF1 LRP5 BRCA2 POLK HRAS LRP6 APC DVL1 DDB2 E2F2 DVL2 BAK1 DVL3 WNT3 WNT4 FZD1 SOS1 WNT10B SOS2 TCF7L2 WNT10A FZD3 NRAS FZD2 FZD7 PTEN BAX FZD9 WNT7A NFKB2 SHC4 SHC2 SHC3 IGF1R HES1 HES5 JAG2 CETN3 SHC1 NCOA1 NOTCH2 FOS FGFR1 RB1 NBN FLT4 JUN GADD45B GADD45A MRE11A FZD5 GADD45G RAD50 CDK6 FZD8 RAD51 CDK4 GSK3B PARP1 FGF2 ATM ATR EGF FRAT2 CANONICAL AND NON CANONICAL TGF B SIGNALING%WIKIPATHWAYS_20260810%WP3874%HOMO SAPIENS Canonical and non canonical TGF B signaling MAPK14 TGFBR1 LOXL2 BMP1 GREM1 SMAD2 TGFBR2 MAPK8 MAPK9 BMPR1A LOXL4 LOXL1 SMAD4 TGFB1 IMMUNE INFILTRATION IN PANCREATIC CANCER%WIKIPATHWAYS_20260810%WP5285%HOMO SAPIENS Immune infiltration in pancreatic cancer IL12A IL1B IL5 CXCL12 MMP9 VEGFB TNF VEGFC VEGFD CCL5 IL4 CCL2 IFNG IL10 IL13 CXCL1 CXCL5 CXCL8 CSF2 IL17A IL2 VEGFA LGALS9 CCL20 IL23A REG4 IL6 IL17F TGFB1 IL17D IL17C IL17B IL12B CCL28 CHOLESTEROL METABOLISM WITH BLOCH AND KANDUTSCH RUSSELL PATHWAYS%WIKIPATHWAYS_20260810%WP4718%HOMO SAPIENS Cholesterol metabolism with Bloch and Kandutsch Russell pathways MVK ELOVL2 MSMO1 CYP46A1 ACAT2 TM7SF2 EBP SC5D MYLIP GGPS1 ELOVL3 NR1H3 DHCR24 LBR ACSL3 SOAT1 MVD FADS2 ACSL1 CH25H FASN ABCG1 FADS1 CYP27A1 HSD17B7 DHCR7 HMGCS1 SREBF2 IDI1 FDFT1 FDPS FACL4 NR1H2 CYP51A1 ABCA1 SQLE SCD SOAT2 HMGCR ELOVL5 ELOVL4 INTERFERON TYPE I SIGNALING%WIKIPATHWAYS_20260810%WP585%HOMO SAPIENS Interferon type I signaling IFNAR2 TYK2 STAT1 STAT3 VAV1 IFNAR1 STAT4 SOCS1 STAT2 JAK1 RAPGEF1 CRKL RAP1A MLST8 SOCS3 REL CREB1 PRMT1 MAP2K3 PIK3CD PIAS1 PIK3R2 PIK3R1 MTOR IRF9 EIF4EBP1 FYN RAC1 EIF4E MAP2K6 PTPN6 IRS1 MAPKAP1 PTPN11 MAPK14 EIF4A1 RPTOR RPS6KA4 RPS6KA5 EIF4B RPS6 RPS6KB1 CBL CRK ZAP70 LCK MAP3K1 PTPRC GAB2 NEOVASCULARIZATION PROCESSES%WIKIPATHWAYS_20260810%WP4331%HOMO SAPIENS Neovascularization processes NFKB1 TGFBR1 CXCL12 MMP9 CXCR4 RELA NOTCH3 MAPK9 NOTCH4 KDR MAPK1 DLL4 FLT4 NOTCH1 MAPK3 HIF1A NFKB2 SMAD2 EPHB2 DKFZp781O1323 MAPK8 RELB REL SMAD1 SMAD9 KITLG TGFB1 ANGPT1 KIT ACVRL1 EPHB4 MIR 222 IN EXERCISE INDUCED CARDIAC GROWTH%WIKIPATHWAYS_20260810%WP3938%HOMO SAPIENS miR 222 in exercise induced cardiac growth HIPK1 HIPK2 CDKN1B HMBOX1 FANCONI ANEMIA%WIKIPATHWAYS_20260810%WP5465%HOMO SAPIENS Fanconi anemia DCLRE1B CTDP1 CEBPD UHRF2 BRCA2 UHRF1 FAAP24 BRIP1 SLX4 USP1 MEN1 HEL-S-125m FANCM NBN CENPX FANCL REV1 FANCA FANCB FANCE FANCD2 PALB2 FANCG FANCF MAD2L2 PTEN SMARCA4 RAD51C UBE2T RFWD3 ERCC1 CENPS MRE11A MCM2 RAD50 RAD51 ATM EGFR ATR FAN1 PPAR SIGNALING%WIKIPATHWAYS_20260810%WP3942%HOMO SAPIENS PPAR signaling ACOX1 PLTP APOA5 PCK1 NR1H3 CYP7A1 FADS2 ACSL1 APOC3 UCP1 CYP27A1 RXRB PLIN1 NR1C1 RXRA CD36 NR1C2 SLC27A1 AQP7 DBI CPT2 RXRG PCK2 HEL-S-104 CPT1C CYP8B1 FABP1 UBC EHHADH SLC27A5 ANGPTL4 SLC27A4 OLR1 HEL-S-28 CYP4A11 PPARG SCD APOA2 LPL PDPK1 ME1 PYRIMIDINE METABOLISM%WIKIPATHWAYS_20260810%WP4022%HOMO SAPIENS Pyrimidine metabolism DTYMK PRIM1 POLD3 POLD4 POLR2A POLR2B POLR2D POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L POLR2J3 DUT PNPT1 POLR2J2 CDA ENPP1 POLR3GL DPYS DHODH TYMP POLE4 POLA1 POLA2 POLR3A TK1 POLR3B POLR3C RRM1 POLE2 RRM2 POLR3D POLE3 POLR3F POLR3G POLR3H UCK2 POLR3K UCK1 DPYD UMPS POLR3E TYMS POLR2C POLD2 RRM2B ENPP3 HEL74 POLE ENTPD1 ENTPD3 CAD NME2 NME3 CTPS2 NME4 DCTD NME6 NME7 POLR1A POLR1C CMPK1 POLR1D CMPK2 POLR1F UPRT POLR1H DCTPP1 PRIM2 DYRK1A INVOLVEMENT REGARDING CELL PROLIFERATION IN BRAIN DEVELOPMENT%WIKIPATHWAYS_20260810%WP5180%HOMO SAPIENS DYRK1A involvement regarding cell proliferation in brain development LIN9 CRY2 PSENEN AKT1S1 SPRY2 CSNK1A1 LIN54 GMNN DCAF7 DNER LIN52 RBL2 RBL1 TFDP1 TFDP2 HES1 TFDP3 HES5 AMPH LIN37 E2F4 E2F5 CCND1 EIF2B5 REST TFAP4 NEUROG2 MLST8 DYRK1A PSEN1 CREB1 FOXO1 CASP9 CDKN1B BACE1 APP TSC2 TSC1 CASP3 MTOR NOTCH1 DEPTOR RBBP4 RPTOR CDK6 CDK4 GSK3B FGF2 LATS2 SIRT1 NFATC1 H3F3B EXTRACELLULAR VESICLES IN THE CROSSTALK OF CARDIAC CELLS%WIKIPATHWAYS_20260810%WP4300%HOMO SAPIENS Extracellular vesicles in the crosstalk of cardiac cells IGF1 HEL-S-44 MMP9 TLR4 HEL-S-102 STAT3 EGFR BIRC5 CD63 CD81 KDR IL6 PTEN GATA4 EGF opn ETS2 PANCREATIC CANCER SUBTYPES%WIKIPATHWAYS_20260810%WP5390%HOMO SAPIENS Pancreatic cancer subtypes TNS4 KRT6C FAM83A KRT6A SERPINB3 BTNL8 FGFBP1 S100A2 KRT7 ANXA10 LYZ LEMD1 DHRS9 CEACAM6 SCCA2 LY6D TFF3 TFF2 CYP3A7 TFF1 VGLL1 CLRN3 SPRR1B PLA2G10 SCEL CDH17 SPRR3 ST6GALNAC1 HEL-S-116 GPR87 REG4 HEL136 KRT20 CST6 AREG LGALS4 TSPAN8 VSIG2 AGR3 FAM3D EUKARYOTIC TRANSCRIPTION INITIATION%WIKIPATHWAYS_20260810%WP405%HOMO SAPIENS Eukaryotic transcription initiation POLR2A POLR2B CDK7 POLR2G POLR2C POLR2H POLR2I POLR2J POLR2K CCNH GTF2B TAF9 POLR3B GTF2E1 GTF2E2 POLR2F POLR3D GTF2H2C_2 TBP TAF12 TAF13 POLR3H GTF2H2 POLR3K GTF2H3 GTF2F2 GTF2H4 ERCC2 TAF7 TAF6 TAF5 MNAT1 POLR3E HEL-S-28 POLR1A POLR1D PI3K AKT MTOR VITAMIN D3 SIGNALING%WIKIPATHWAYS_20260810%WP4141%HOMO SAPIENS PI3K AKT mTOR vitamin D3 signaling IL12A PFKFB4 PDHA1 HEL-S-133P GSK3B PRKAA2 MYC TSC2 TSC1 RELA MTOR NR1i1 SLC2A3 CYP24A1 HK3 RXRA IL10 CD80 EV RELEASE FROM CARDIAC CELLS AND THEIR FUNCTIONAL EFFECTS%WIKIPATHWAYS_20260810%WP3297%HOMO SAPIENS EV release from cardiac cells and their functional effects ERBB4 MYB CXCL12 RGS16 PRL KLF2 PRION DISEASE PATHWAY%WIKIPATHWAYS_20260810%WP3995%HOMO SAPIENS Prion disease pathway CASP12 NFKB1 SMC3 SPI1 RAD21 HEL-S-125m STAT3 CTCF HEL-S-89n CASP3 MAPK1 FYN RXRA MAPK3 TBP MEF2C POU2F2 CHD2 PRNP HEL-S-269 EP300 PAX5 BATF IRF4 RFX5 CREB1 BCL2 FGFR1 NCAM1 MAJOR RECEPTORS TARGETED BY EPINEPHRINE AND NOREPINEPHRINE%WIKIPATHWAYS_20260810%WP4589%HOMO SAPIENS Major receptors targeted by epinephrine and norepinephrine ADCY3 ADCY1 ADCY8 ADCY6 ADCY5 ADRB1 HEL-S-7a ADRB2 ADRA2C ADRA2B ADRA2A ADRA1D ADCY9 TRANSCRIPTION FACTOR REGULATION IN ADIPOGENESIS%WIKIPATHWAYS_20260810%WP3599%HOMO SAPIENS Transcription factor regulation in adipogenesis PCK2 CEBPD CEBPA CEBPB LEP NR3C1 TNF MAPK8 TWIST1 PPARG LPIN1 PPARGC1A IL6 RXRA CREB1 INSR IRS1 SLC2A4 FOXO1 ACETYLCHOLINE SYNTHESIS%WIKIPATHWAYS_20260810%WP528%HOMO SAPIENS Acetylcholine synthesis PDHA1 ACHE PEMT ChAT PDHA2 CHKA DEVELOPMENT OF URETERIC DERIVED COLLECTING SYSTEM%WIKIPATHWAYS_20260810%WP5053%HOMO SAPIENS Development of ureteric derived collecting system FREM2 EYA1 ETV4 GDNF RET CELSR1 BMP2 GRIP1 BMP7 DCN SHH SIX1 BMP5 SMO FST CCND1 NR1B3 PAX2 BMPR1A SALL1 RARB BMPER BMP4 SIX2 GPC3 SMAD1 GLI3 GDF11 TGFB1 CRIM1 ETV5 CTDNEP1 FRAS1 RARA HOXD11 ANOS1 HOXA11 SPRY1 FREM1 NF KB SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260810%WP5527%HOMO SAPIENS NF kB signaling and ARTD family members ZC3HAV1 TIPARP PARP16 PARP12 PARP10 PARP14 MAP3K14 ERN1 NFKB2 NFKBIA RBX1 GSK3B PARP1 IKBKB EP300 RELB IKBKG CREBBP TFPI2 BTRC MAVS SKP1 CLDN6 CHUK RIGI TBK1 IL17 SIGNALING%WIKIPATHWAYS_20260810%WP2112%HOMO SAPIENS IL17 signaling NFKB1 TRAF6 CEBPD TRAF3IP2 IL17RB MAP3K14 STAT3 RELA MAPK1 JAK1 MAPK3 SP1 CEBPB GSK3B IKBKB IL17RC IL17A IL17RA IKBKG MAP3K7 IL17F IL17D IL17C IL17B NFKBIB TRAF3 PI3K AKT MTOR SIGNALING AND THERAPEUTIC OPPORTUNITIES IN PROSTATE CANCER%WIKIPATHWAYS_20260810%WP3844%HOMO SAPIENS PI3K AKT mTOR signaling and therapeutic opportunities in prostate cancer RICTOR CDKN1B RPTOR GRB10 FOXO4 HRAS GSK3B TFEB RHEB PIK3R3 TSC2 PIK3R2 PIK3R1 MTOR MLST8 NRAS EIF4EBP1 FOXO3A BAD ULK1 PTEN RB1CC1 FOXO1 MAPKAP1 CANCER IMMUNOTHERAPY BY CTLA4 BLOCKADE%WIKIPATHWAYS_20260810%WP4582%HOMO SAPIENS Cancer immunotherapy by CTLA4 blockade PIK3R1 HLA-DRB1 CTLA4 PPP2CA PIK3CD PTPN6 PIK3R3 CD80 PTPN11 PIK3R2 TAMOXIFEN METABOLISM%WIKIPATHWAYS_20260810%WP691%HOMO SAPIENS Tamoxifen metabolism CYP2A6 CYP1A1 CYP1B1 CYP1A2 CYP2E1 CYP3A4 UGT2B15 CYP2C19 SULT1A1 UGT1A4 UGT1A8 UGT2B7 CYP2C9 SULT1E1 SULT2A1 UGT1A10 EXERCISE AND HYPERTROPHY IN SKELETAL MUSCLE%WIKIPATHWAYS_20260810%WP516%HOMO SAPIENS Exercise and hypertrophy in skeletal muscle IL1A ADAM10 IL1R1 JUND IL18 MYOG HEL-S-52 IFRD1 DUSP14 ANKRD1 VEGFA NR4A3 EIF4EBP1 IFNG EIF4E ATF3 HBEGF MSTN CYR61 P53 TRANSCRIPTIONAL GENE NETWORK%WIKIPATHWAYS_20260810%WP4963%HOMO SAPIENS p53 transcriptional gene network AURKA POLK APAF1 DDB2 ULK2 GPX1 E2F7 BTG2 SMR3B ACAD11 PTEN SERPINB5 BAX MSH2 TRAF4 SCO2 ADGRB1 AKT1S1 XPC DRAM1 ZMAT3 PERP TP53INP1 RPRM TIGAR THBS1 SIVA1 FUCA1 TNFRSF10D TP53I3 ERCC5 PRKAA2 ULBP2 ULBP1 CX3CL1 MLST8 PCNA SESN2 SLC7A11 TP53AIP1 PIDD1 SESN1 PRKAA1 NCF2 TNF BBC3 TSC2 LIF RRM2B PRKAB2 MTOR PRKAG1 CCNE1 IRF9 CCNG1 PRKAG2 CCL2 PMAIP1 PRKAB1 SFN NOTCH1 PRKAG3 GADD45A ADORA2B TNFRSF10B PML DEPTOR RPTOR CPT1C XRCC5 CDK2 DDIT4 ULK1 GLS2 ISG15 TNFSF6 CDKN1A FGF23 SIGNALING IN HYPOPHOSPHATEMIC RICKETS AND RELATED DISORDERS%WIKIPATHWAYS_20260810%WP4790%HOMO SAPIENS FGF23 signaling in hypophosphatemic rickets and related disorders NFKB1 ORAI1 FGF23 SLC34A1 ALPL FGFR2 SLC34A3 KL GALNT3 FAM20C CCND1 ROS1 ENPP1 CYP27B1 CYP24A1 DMP1 opn PTH CYP11B2 FGFR3 CDKN1A NFKB2 HYPOTHETICAL CRANIOFACIAL DEVELOPMENT PATHWAY%WIKIPATHWAYS_20260810%WP3655%HOMO SAPIENS Hypothetical craniofacial development pathway ARHA ARHGEF2 TP63 IRF6 TFAP2A ARHGAP29 MITOCHONDRIAL COMPLEX II ASSEMBLY%WIKIPATHWAYS_20260810%WP4920%HOMO SAPIENS Mitochondrial complex II assembly SDHB SDHAF2 SDHAF3 SDHAF1 SDHAF4 SDHC SDHD SDHA NOTCH1 REGULATION OF ENDOTHELIAL CELL CALCIFICATION%WIKIPATHWAYS_20260810%WP3413%HOMO SAPIENS NOTCH1 regulation of endothelial cell calcification GJA5 ALPL SOX6 JAG2 VEGFA DLL3 DLL4 MGP PLAT CALU NOTCH1 FGFR3 LPAR1 ITGA1 HDAC6 INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM%WIKIPATHWAYS_20260810%WP5426%HOMO SAPIENS HDAC6 interactions in the central nervous system AURKA PRKCZ CSNK2A2 APC CSNK2B BIRC5 SQSTM1 DCTN1 TUBA1C FREP1 SNCA TUBB BAX GSK3A HEL113 HEL-S-44 SP1 MYD88 NR3C1 TUBA4A HEL-S-102 EGFR IKBKAP HTT PARK2 HDAC11 CDC20 KAT5 CD133 FAT10 ELP3 TUBA2 FOXP3 ERG OPTN CFTR ITIH4 NEDD9 KALRN ATXN3 RHOT1 ADRBK1 HSF1 EP400 CCDC141 SGK1 HSPA4 MAP1B FUS MAPRE1 MIIP TARDBP ARID3A BBIP1 SNCAIP GARS1 CNOT6 MAP1LC3A PTK2B DLG2 CYBB TWIST1 MAPK1 HEL-S-2a STUB1 RAC1 MAP3K5 MAPK3 VCP HIF1A SHH GRIA2 SMAD2 GSK3B EP300 MAPK8 DLG4 PXN SIRT2 PRKCE HEL-S-32 MYH9 VHL ISG15 BCL2 HEL-S-67p POU5F1 HEL-S-72p APOE BDNF COMPLEMENT ACTIVATION%WIKIPATHWAYS_20260810%WP545%HOMO SAPIENS Complement activation C4A MASP1 CD55 C1QC CFD CFB HEL-S-62p C4B_2 C1QB C1QA C1S CFP C8A C6 C8G C7 C9 MASP2 AMYOTROPHIC LATERAL SCLEROSIS ALS %WIKIPATHWAYS_20260810%WP2447%HOMO SAPIENS Amyotrophic lateral sclerosis ALS CASP12 TNFRSF1A BCL2L1 APAF1 MAP2K2 TNF GPX1 CASP3 BAD RAC1 BAX MAP2K6 MAP3K5 HEL-S-2 MAPK14 HEL-S-44 SMIM40 NEF3 TOMM40 DERL1 NEFH CCS PPP3CA RAB5A PPP3CC NEFL SLC1A2 BCL2 CASP9 CYTOSINE METHYLATION%WIKIPATHWAYS_20260810%WP3585%HOMO SAPIENS Cytosine methylation HEL-S-26 TDG MBD3 TET2 TET1 RETINOL METABOLISM%WIKIPATHWAYS_20260810%WP5188%HOMO SAPIENS Retinol metabolism CYP2A6 CYP1A1 RPE65 DHRS4 SDR16C5 DHRS9 CYP2W1 RDH12 AWAT2 PNPLA4 AOX1 CYP3A7 LRAT BCO1 ADH1A HEL-S-53e PHOSPHODIESTERASES IN NEURONAL FUNCTION%WIKIPATHWAYS_20260810%WP4222%HOMO SAPIENS Phosphodiesterases in neuronal function PDE4D ADCY3 PDE2A ADCY1 PDE10A GRIN2B PDE12 ADCY8 DRD1 PPP1R1B PDE3A ADCY6 PDE5A PDE7B PDE9A ADCY5 HEL-S-7a ADCY9 ADORA2A PDE7A GUCY1B1 CAMK2A GRIN1 CHRNA7 PDE1C PDE1B PRKG1 PDE1A PDE3B PDE11A CREB1 PDE6D PDE4B PDE8A PDE4A PDE6C PDE6A DRD2 GUCY1A2 PDE6H PDE6G MAPK PATHWAY IN CONGENITAL THYROID CANCER%WIKIPATHWAYS_20260810%WP4928%HOMO SAPIENS MAPK pathway in congenital thyroid cancer MAP2K1 GAREM2 MAP2K2 MYC SOS1 SOS2 SHC1 ALK RAF1 KSR1 BRAF JUN FOS MAPK3 INTERLEUKIN 1 IL 1 STRUCTURAL PATHWAY%WIKIPATHWAYS_20260810%WP2637%HOMO SAPIENS Interleukin 1 IL 1 structural pathway MAP3K8 NFKB1 TRAF6 IRF7 MAP2K3 IL1R1 MAP2K1 MAP3K14 MAP2K2 SAFB RELA MAPK9 MAPK1 IRAK1 EIF4E IRAK2 MAPK10 MAP2K6 MAP3K7IP1 MBP MAPK11 MAPK3 NFKBIA MAPK14 TAB3 MYD88 RPS6KA5 IL1A MYC IKBKB ATF2 MAPK8 MAPKAPK2 MAP3K7 MAP2K4 TANK MAP3K1 IRAK4 CHUK FOS NFKBIB CLEAR CELL RENAL CELL CARCINOMA PATHWAYS%WIKIPATHWAYS_20260810%WP4018%HOMO SAPIENS Clear cell renal cell carcinoma pathways HEL-S-133P ENO1 PSAT1 HEL-S-68p PHGDH KDM5C EFCAB3 PSPH STAT3 PFKL PLOD2 ENO2 ENO3 FASN PGM2 CEP290 SQSTM1 PBRM1 ALDOB SDSL PGBD5 LDHD PTEN HK3 KCNJ2 HEL-S-49 PDGFRA SSPN SHMT1 PFKP HEL-S-51e BAP1 AKT1S1 FLT1 HEL-S-87p EGFR PFKM MLST8 ACACA CREBBP KSR1 RAPGEF5 RHEB HEL-S-281 TSC2 TSC1 KDR MTOR BHLHE41 HIF1A ACACB DEPTOR SETD2 RPTOR HEL-S-162eP GRB10 ACLY ENPP3 EP300 PKLR VEGFA CAMK1 MAP2K5 HEL-S-32 VHL HEL-S-30 HK2 ME1 INSULIN SIGNALING IN ADIPOCYTES DIABETIC CONDITION %WIKIPATHWAYS_20260810%WP3635%HOMO SAPIENS Insulin signaling in adipocytes diabetic condition MTOR TBC1D4 INSR RPS6 RPS6KB1 IRS1 SLC2A4 BLADDER CANCER%WIKIPATHWAYS_20260810%WP2828%HOMO SAPIENS Bladder cancer RB1 SRC HRAS MAP2K1 MMP9 MAP2K2 PIK3R2 PIK3R1 TYMP NRAS MAPK1 RAF1 HBEGF RASSF1 DAPK2 UPK3A THBS1 RPS6KA5 CDK4 ARAF MDM2 CXCL8 MYC EGFR CCND1 CDKN2A ERBB2 MMP2 VEGFA BRAF EGF FGFR3 CDKN1A IL3 SIGNALING%WIKIPATHWAYS_20260810%WP286%HOMO SAPIENS IL3 signaling YWHAQ HEL-S-1 BCL2L1 SRC HRAS MAP2K1 PIK3CD STAT3 VAV1 PIK3R2 SOS1 PIK3R1 INPP5D MAPK1 FYN BAD RAF1 JAK1 JUN MAPK3 PTPN6 CSF2RB PTPN11 LYN CCR3 CD69 RAPGEF1 CRKL ENPP3 CXCL8 MAPK8 CBL SHC1 STAT5B IL3 SYK TGFB1 FOS BCL2 IL3RA GRB2 IL5RA GAB2 MIR TARGETED GENES IN LYMPHOCYTES%WIKIPATHWAYS_20260810%WP2004%HOMO SAPIENS miR targeted genes in lymphocytes PDE3A P4HA2 PSAT1 CPNE8 VEZT PWP1 PNP DHX57 CIAO2A POGLUT3 TDG GOLGA7 SLC38A1 RARS1 ATP6V0E1 FBXW11 FNDC3B FNDC3A NCL RAI14 SRSF9 POM121 PISD TMED10 MTRR CBFB SERPINE2 ADIPOR2 TMEM41B RTN4 BACH1 UBE2J1 GPAM RRP8 MRPL20 LOC541469 COMMD9 CHORDC1 ATP6V1C1 ABCG2 CEBPB RAVER2 ATP6V1F SEC62 HMGA1 CDIPT VPS39 SLC4A10 CDK5RAP3 TBCA HOXA5 PEDS1-UBE2V1 EGFR MBNL1 MOV10 PPIF CARHSP1 CCND1 CHMP2A WDR82 SRPRB SUCLG2 ANP32B FAR1 DKFZp761E1322 OTULINL RNP24 HACD3 PICALM IQGAP3 ARF4 TPM3 FXR2 NRP1 RDH10 TRAM1 GRPEL2 ATP2A2 CEP72 ADAR KCNN4 MRC2 VTI1B GYS1 SNX6 TUBA1A GSTM4 SPTLC1 PHC2 SH3BGRL3 HARS1 ELOVL5 NFIA CYR61 RAB27B PRPF40A RHOB BRI3BP HEL-S-26 PPP5C GNA13 NCEH1 CSDE1 SFXN1 PXDN STRN PTMA FERMT2 MRPS33 HOXD8 AKAP8 CACNA2D1 RCOR1 DNAJB1 GFM1 POLR2C ASH2L PPP1R7 MEOX2 BACE1 POLD2 COIL SH3BP4 SERP1 E2F3 MAGT1 TMED3 PDLIM7 DHX15 MPZL1 NELFCD SLC12A2 CTSC GALNT7 MRPS24 GALNT1 TMT1A AP3D1 AP3B1 ARCN1 NARS1 SLC7A6 TMEM59 MPDU1 CDCP1 SPCS3 FRG1 FMNL2 PTRH1 AXL VAMP3 NEDD4 SSNA1 LAMTOR5 NOTCH1 ATG3 AMIGO2 CUL4B NAPG BET1 PGRMC1 TAF9B IRS1 SRSF10 MTX1 NT5E SPRYD4 MYB TRMT1 TTC9C TNLG5A ARHG WDR11 ATAT1 TPPP3 SNX15 TRIP13 LAMC2 LY6K TUSC2 GEMIN2 LTN1 CPOX ARID4B MSI2 TXN2 ABHD10 ABHD11 ARID2 KPNA3 ATG9A STX7 UBE4A CDKAL1 KIT HEL-S-66 RAB30 SYPL1 GPD2 GEMIN7 PPIB NPR3 BDNF SLC1A4 MAP3K8 CORO1C SAC3D1 CD164 BRPF3 TNFRSF10A IGF2R GNL3L BCL6 TRPV6 MENT SLC25A1 DOCK5 ADPGK CALCOCO2 DOCK7 TNFAIP2 PTBP1 TMEM109 ACP2 SNAP29 SCYL1 UTP15 HSDL1 MARS2 RBM19 ARID1A NT5C3A PLK1 RCN2 RFT1 RBMS1 LUZP1 SNAP23 NUFIP2 PTPRF UNC93B1 RAB5C NXN MRM1 CAP1 HEL-S-47e CAND1 RAB23 IGF2BP1 ZNF622 ABCF2 SLC25A24 NHERF2 SLC4A7 RQCD1 SLC25A32 TMED7 CSNK1D NOTCH2 DDX5 RB1 SHOC2 CDKN1B CXCL12 UHRF1 PANX1 USP1 SMC1A SLC25A13 EZH2 MAPK12 TNFRSF10B CDK6 ITGA2 C1QBP PLXND1 DNMT3B LMNB2 HEL-S-30 PPP3R1 GNPNAT1 PRIM1 GFPT1 MYLIP POLE4 POLA2 MTHFD2 DCAF7 SEC23A CYP51A1 AURKB LAMTOR3 RHEB FADS2 FADS1 SLC25A22 EIF4E MCL1 CHAF1A ELMOD2 TERT HSD17B12 HEL-S-273 PKN2 PRKCI PURA HEL-S-108 ANXA2 TPM1 BCL2 LPL PPP2R5C CDKN1A YWHAQ AP2A1 EHMT1 TGFBR2 IFRD1 PLAG1 ARL10 ANAPC1 TP53INP1 LAMC1 CYP1B1 CLDN1 COL4A2 CDKN2A UBE2S SMAD1 TYMS HMOX1 SYNE2 SYNE1 TMEM43 PTPA SDCBP GAS2L1 VCAM1 CDKN1C MAPK14 FGF2 PPP3CA NF2 MAPK7 TCL1A HEL-S-303 MYO1E IL11 SIGNALING%WIKIPATHWAYS_20260810%WP2332%HOMO SAPIENS IL11 signaling SRC HRAS MAP2K1 TYK2 MAP2K2 STAT1 STAT3 RELA PTPA BIRC5 PIK3R2 PIAS1 PIK3R1 MAPK1 FYN RAF1 JAK1 IBSP MAPK3 BGLAP RUNX2 PTPN11 ITGA2 RPS6KA1 IL11 RPS6 RPS6KB1 ATF1 IKBKB FES SOCS3 CREB1 TGFB1 IL11RA YES1 CHUK BCL2 IL6ST PDPK1 GRB2 EBOLA VIRUS INFECTION IN HOST%WIKIPATHWAYS_20260810%WP4217%HOMO SAPIENS Ebola virus infection in host NFKB1 CDC42 STAT1 PAK1 VAV2 TIAM1 IL4 ITGB3 ITGAV VPS39 ADAM17 EGFR RELB CREBBP REL RHOB PIK3CD PIK3R3 PIK3R2 PIK3R1 MAPK1 AXL NEDD4 MAPK3 EIF2S1 EP300 ACTG1 ARHA HLA-DMA RIGI TBK1 CAV3 HLA-B HLA-DRB1 HLA-C HLA-A HLA-F HLA-G HLA-E RAB7A ACTN1 CLTB CAV2 NFKB2 ITGB1 ITGA1 IGF1R FLNA FLNB RAB5A CLEC4M CLEC10A ICAM2 ICAM3 HLA-DOA SOCS3 HLA-DOB MBL2 KPNA1 VPS18 CD300A VPS33A TIMD4 RASA2 TYRO3 TSG101 SCIN HLA-DQA2 IRF3 HLA-DQA1 VPS16 PS1TP5BP1 HLA-DRB5 BST2 CD209 CLEC6A IRF7 ASGR1 HAVCR1 HAVCR2 EIF2AK2 HLA-DPA1 NPC1 TLR4 NPC2 MFGE8 HLA-DQB2 HLA-DQB1 RFC1 VPS4A RELA HLA-DMB DAB2IP MERTK VPS41 HLA-DPB1 RAB9A FOLR1 RAC1 CLTC CLTA TFAP2A ITGA4 ITGA2 CTSL C1QBP ITGA6 CLTCL1 ACTN4 IKBKE IQGAP1 CELL TYPE DEPENDENT SELECTIVITY OF CCK2R SIGNALING%WIKIPATHWAYS_20260810%WP3679%HOMO SAPIENS Cell type dependent selectivity of CCK2R signaling RYR3 PLCB1 DAGLA TRPC1 CCK CCKBR CNR1 RYR1 RYR2 GNAI1 HALLMARK OF CANCER METASTASIS AND EPITHELIAL TO MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260810%WP5469%HOMO SAPIENS Hallmark of cancer metastasis and epithelial to mesenchymal transition ELF5 SIX1 SNAI1 TCF4 HDAC2 KDM1A ZEB2 HDAC1 TWIST1 SIRT1 EZH2 TGFB1 SUV39H1 SUZ12 FOXC2 PRRX1 SNAI2 KLF8 ELF3 GSC2 PREGNANE X RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2876%HOMO SAPIENS Pregnane X receptor pathway ABCC2 CYP2A6 DNAJC7 UGT1A1 UGT1A3 UGT1A9 CYP3A4 SRC CYP2C19 UGT1A4 NCOA1 CYP3A7 CYP2C9 SULT2A1 NR1i2 PPARGC1A CYP4F12 RXRA ABCC3 ABCB1 FOXO1 CYP2B6 SLCO1B1 SRPX2 SOMATROPH AXIS GH AND ITS RELATIONSHIP TO DIETARY RESTRICTION AND AGING%WIKIPATHWAYS_20260810%WP4186%HOMO SAPIENS Somatroph axis GH and its relationship to dietary restriction and aging MTOR SIRT1 PTEN IGF1R FOXO1 COMMON PATHWAYS UNDERLYING DRUG ADDICTION%WIKIPATHWAYS_20260810%WP2636%HOMO SAPIENS Common pathways underlying drug addiction PS1TP5BP1 ADCY1 ADCY8 DRD1 DRD4 CALM1 MAP2K1 MAP2K2 CAMK4 MAPK1 RAF1 MAPK3 PPP1CC PRKCA GNAI1 GJB1 HEL-S-80p PPP1R1A GRIA2 ARAF CAMK2A PRKCB GRIN1 ACTG2 RAP1A ACTG1 PRKACG GNAS GRIA3 GRIA4 CREB1 DRD2 FABP4 IN OVARIAN CANCER%WIKIPATHWAYS_20260810%WP4400%HOMO SAPIENS FABP4 in ovarian cancer HEL-S-104 ALLOGRAFT REJECTION%WIKIPATHWAYS_20260810%WP2328%HOMO SAPIENS Allograft rejection IL12A HLA-B HLA-DRB1 HLA-C HLA-A HLA-F HLA-G PRKCZ CSNK2A2 HLA-E STAT1 HEL-S-62p BHMT2 TUBA1B IL4 IL13 PDGFRA CXCL11 HEL113 PRF1 CD40 CXCL9 CXCL8 PECR CASP8 IL2 HLA-DOA CD40LG HLA-DOB CASP9 FOXP3 HLA-DQA2 HARS1 HLA-DQA1 IL1B HLA-DRB5 IL5 IL2RA CXCL12 GDNF HLA-DPA1 TNF HLA-DQB1 HLA-DMB CASP3 HLA-DPB1 IFNG C1QB C1QA GABPA IL10 C8A C6 C7 C9 C4A CD55 AGTR1 C1QC IL22 CXCL13 IL1A IL-21 GNLY CXCR5 MICA LRRK2 CCL21 IL17A CTLA4 VEGFA HLA-DMA C4B_2 TGFB1 TNFSF6 CCL19 CD80 ABCB1 IL12B MSMP EXPRESSION REGULATION IN CANCER CELLS AND ITS PRO ANGIOGENIC ROLE IN OVARIAN TUMORS%WIKIPATHWAYS_20260810%WP4397%HOMO SAPIENS MSMP expression regulation in cancer cells and its pro angiogenic role in ovarian tumors CCR2 MSMP CTCF FIBRIN COMPLEMENT RECEPTOR 3 SIGNALING%WIKIPATHWAYS_20260810%WP4136%HOMO SAPIENS Fibrin complement receptor 3 signaling NFKB1 TRAF6 TICAM2 SRC NOS2 TLR4 TLR3 TNF TICAM1 RELA FGA LY96 CCL2 IFNB1 ITGAM IRAK1 PLAT IRAK2 PLG CD14 HEL-S-78p MYD88 CXCL3 IKBKB FCER1G TYROBP ARHA IKBKG LBP REL SYK IL6 IRAK4 CHUK TIRAP IRF3 IL12B DENGUE 2 INTERACTIONS WITH COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260810%WP3896%HOMO SAPIENS Dengue 2 interactions with complement and coagulation cascades HEL-S-62p F10 SERPINF2 PLAT PLG F3 HEL-S-78p F5 F7 F2R F8 F9 CFD CFB VWF C1QB C1QA F13B CLTC C1S C6 SERPINA1 C8G C7 C9 MASP2 MASP1 KNG1 THBD CD55 C1QC BDKRB1 SERPING1 KLKB1 CR1 PROS1 PLAUR CLU F2 C3AR1 CR2 CD46 CPB2 CFH SERPINC1 C4B_2 CFI C5AR1 TFPI APOA2 LMAN1 SERPIND1 PROC WNT BETA CATENIN SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260810%WP5529%HOMO SAPIENS Wnt Beta catenin signaling and ARTD family members RBX1 PARP10 APC PARP1 DVL1 DVL2 DVL3 AXIN1 BTRC SKP1 PLK1 TNK2 TNK1 GUT LIVER INDOLE METABOLISM %WIKIPATHWAYS_20260810%WP3627%HOMO SAPIENS Gut liver indole metabolism CYP2E1 MICRORNA FOR TARGETING CANCER GROWTH AND VASCULARIZATION IN GLIOBLASTOMA%WIKIPATHWAYS_20260810%WP3593%HOMO SAPIENS MicroRNA for targeting cancer growth and vascularization in glioblastoma VEGFA HES1 VEGFB VEGFC HIF1AN HIF1A METABOLISM OF ALPHA LINOLENIC ACID%WIKIPATHWAYS_20260810%WP4586%HOMO SAPIENS Metabolism of alpha linolenic acid ALOX5 ALOX12 FADS1 PTGS2 FADS2 ALOX15 CODEINE AND MORPHINE METABOLISM%WIKIPATHWAYS_20260810%WP1604%HOMO SAPIENS Codeine and morphine metabolism ABCC2 UGT1A1 UGT1A3 UGT1A9 CYP3A4 ABCC3 UGT1A10 ABCB1 UGT2B4 UGT1A8 UGT2B7 SLCO1B1 TRANSCRIPTION FACTORS REGULATE MIRNAS RELATED TO CARDIAC HYPERTROPHY%WIKIPATHWAYS_20260810%WP1559%HOMO SAPIENS Transcription factors regulate miRNAs related to cardiac hypertrophy NFKB1 TGFB1 PPP3R1 STAT3 MYEF2 RASGRF1 TNF RELATED WEAK INDUCER OF APOPTOSIS TWEAK SIGNALING%WIKIPATHWAYS_20260810%WP2036%HOMO SAPIENS TNF related weak inducer of apoptosis TWEAK signaling TNFSF12 NFKB1 MAP3K14 TNF RELA MAPK9 CASP3 MAPK1 RAF1 RAC1 RIPK1 JUN FADD MAPK3 TRAF5 NFKB2 NFKBIA MAPK14 TRAF1 GSK3B IKBKB MAPK8 RELB TRAF2 CASP8 HDAC1 MAP3K7 TRIM63 BIRC2 BIRC3 CHUK NFKBIB TNFRSF12A TRAF3 ATM SIGNALING%WIKIPATHWAYS_20260810%WP2516%HOMO SAPIENS ATM signaling H2AX MDC1 TP53BP1 CRADD PIDD1 CHEK2 TP73 CHEK1 TLK1 NBN MAPK9 DKFZp781B1423 SMC1A CCNE1 CCNB1 RIPK1 JUN GADD45A MRE11A CDC2 RAD50 RAD51 CDK2 MDM2 ATM RAD9A ATF2 IKBKG CASP2 CREB1 CDKN1A GPCRS CLASS C METABOTROPIC GLUTAMATE PHEROMONE%WIKIPATHWAYS_20260810%WP501%HOMO SAPIENS GPCRs class C metabotropic glutamate pheromone GABBR1 GRM3 GRM2 CASR GRM8 GPRC5A GPRC5D GPRC5C GRM6 GABBR2 NOTCH SIGNALING%WIKIPATHWAYS_20260810%WP61%HOMO SAPIENS Notch signaling NFKB1 SRC MAML2 MAML1 DTX1 MAGEA1 CIRSR STAT3 APH1B SPEN HES6 NOTCH3 PIK3R2 RING1 PIK3R1 SAP30 NOTCH4 NUMB MTOR MAML3 PSENEN DLL3 DLL4 NOTCH1 FBXW7 NCOR1 GSK3B HES1 FHL1 HES5 EP300 ADAM17 HDAC2 JAG2 PSEN2 HDAC1 NCOR2 PSEN1 ITCH LCK NOTCH2 SKP1 SNW1 RBPJ HEY2 2Q37 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5224%HOMO SAPIENS 2q37 copy number variation syndrome DTYMK CALM1 HES6 CXCR4 MROH2A DGKD TRAF3IP1 HJURP ERFE KLHL30 IL13RA1 GABARAPL2 GABARAPL1 THAP4 RRAGA ITGB3 RRAGB RRAGD TWIST2 AGAP1 GABARAP NEU4 OR6B3 MAP4 TRPM8 OR6B2 UBE2F PRL MTERF4 RAB27A COPS8 COPS9 EGFR SNED1 RTP5 RNPEPL1 ING5 SEPT6 MAP1LC3C KIF1A GAL3ST2 ILKAP BOK AQP12B AQP12A ITPK1 GYS1 DUSP28 ANO7 OTOS ARL4C MYOD1 IRF8 USP40 ARF5 ASB18 CENPA CYTH2 GPC1 SPP2 PRLH ANKMY1 NDUFA10 PPP1R7 CYTH1 UGT1A7 SH3BP4 FARP2 SEPTIN2 PDX1 SEPTIN4 MLPH CAPN10 ACKR3 PDCD1 RAB17 RAMP1 ASB1 GBX2 PDGFA DKFZp762B153 UGT1A10 UGT1A1 UGT1A9 MEF2C CALCA RPS6 ABCA1 PER2 UGT1A4 UGT1A8 MYOG DISC1 ARF1 NFKBIA CXCL11 ASCL1 HES1 D2HGDH AGXT TRAF3 IL1B CXCL12 TNF MAP1LC3A RAC1 JUN CALCRL UGT1A3 EEF1A1 HAMP NEDD8 HEL-S-28 KININ KALLIKREIN PATHWAY%WIKIPATHWAYS_20260810%WP5089%HOMO SAPIENS Kinin Kallikrein pathway KNG1 BDKRB2 BDKRB1 SERPING1 KLKB1 CPN1 GLYCOSAMINOGLYCAN DEGRADATION%WIKIPATHWAYS_20260810%WP4815%HOMO SAPIENS Glycosaminoglycan degradation HPSE GUSB HGSNAT HEL-S-111 HPSE2 IDUA HEXA GNS SGSH GLB1 GALNS HYAL2 HYAL4 LEUKOTRIENE METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP5171%HOMO SAPIENS Leukotriene metabolic pathway ALOX5 CYP4F3 DPEP2 LTC4S PTGR1 DECR2 DECR1 ALOX5AP ABCC1 DRUG INDUCTION OF BILE ACID PATHWAY%WIKIPATHWAYS_20260810%WP2289%HOMO SAPIENS Drug induction of bile acid pathway ABCC2 NR1I3 CYP3A4 SLC51A SLC51B ABCB11 CYP7A1 SULT2A1 NR1i1 NR1H4 BAAT NR1i2 ABCC3 ABCB1 SLCO1B1 NUCLEAR RECEPTORS META PATHWAY%WIKIPATHWAYS_20260810%WP2882%HOMO SAPIENS Nuclear receptors meta pathway STAT3 CAP2 ABCC3 ABCC5 TGFBR3 CYP2A6 SP1 GPAM NR3C1 EGFR CCND1 HEL126 CES2 GSTM1 CES1 ANKRD1 FGF13 HSP90AB1 SLC6A19 SLC2A3 MAFG GSTM4 FOXO1 DNAJB1 AMIGO2 NFE2L2 SLCO1B1 ABCC2 UGT1A1 UGT1A9 IL11 HGF BHLHB2 SMARCA1 IL12B IL12A FGD4 POLK TGFA S100P CYP7A1 ABCG8 ABCG5 APOC3 SQSTM1 SERPINB2 ACADM HEL-75 NFKB2 HES1 AHR EGR1 TNFAIP3 NCOA1 CCL20 IL17B SLC2A4 IL1B CDKN1B JUND MFGE8 SMC1A IFNG GADD45B SLC27A1 CYP2B6 CDC2 SRPX2 CPT2 DNAJC7 UGT1A3 CYP8B1 ZIC2 FABP1 CDK4 EHHADH SLC27A5 SLC2A2 SLC2A12 EPHA2 CYP4A11 CYP4F12 ABCB1 UGT2B4 ME1 ACOX1 CYP1A2 PDK4 PCK1 SLC7A5 NR1H3 GPX2 FASN GPX3 CYP2C9 NR1i1 BAAT NR1i2 NR1C1 NR1C2 DBI DNER GCLM SLC19A2 SLC5A5 PTGS2 IL2 BIRC2 SCD BIRC3 TNS4 PLTP APOA5 FGFBP1 UGT1A7 CYP3A7 ACKR3 SULT2A1 RXRA JUNB HBEGF SERPINA1 NQO1 FGF19 PTGR1 GCLC NR1I3 GCC1 ANGPTL4 FTH1 MYC SLC6A18 SLC6A17 SLC6A16 EP300 SLC5A7 SLC5A8 SLC5A9 CES8 CES3 EPHA3 ABCB4 NR1H4 MGST3 MGST1 MGST2 SLC5A1 ADH7 SLC5A2 APOA2 SLC6A20 SLC5A3 GSTM3 SLC5A4 GSTM2 POU5F1 PLK2 SPRY1 HEL-S-128m SLC6A5 SLC6A7 HEL-S-22 SLC6A9 CPEB4 TXN GSTM5 SLC6A2 SLC6A3 EPB41L4B ENC1 SLC2A14 EDN2 CYP2C19 SULT1A1 SLC2A11 TGFBR2 NCOA6 UGT1A4 SLC2A10 TSC22D3 UGT2B7 SLC2A13 MYOF SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 CDC42EP3 AHRR BAX SLC6A11 PMP2 SMVT B3GNT5 GPR153 SERTAD2 CAVIN2 PTGES3 KTN1 GSTA5 GSTA4 CYP1A1 GSTA3 CYP1B1 RGS2 SLC39A9 SLCO2B1 SLC39A6 CYP3A4 SLC39A5 SLC39A8 SLC39A2 SLC39A1 SLC39A3 IGFBP1 AIP CPT1A ALDH3A1 SCNN1A FKBP5 FTL SLC6A13 SLC26A2 ABHD2 GSTT2 IP6K3 PPARGC1A DNAJC15 SLC2A9 MAFF KLK15 ALAS1 NR0B2 SRXN1 SNAI2 SLC2A6 SLC6A8 SLC2A7 SLC2A8 HEL-S-10 ARL5B SRGN HEL-S-25 HMOX1 SLC7A11 NAV3 KAT2B ADGRF4 SLC5A12 SLC5A10 PRRG4 STOM SRC PPP1R14C TNF ABCB11 PTPA CCL2 ALOX5AP JUN KEAP1 CDKN1C THBD AGER CDC37 TGFB1 PDE4B NRG1 DNA MISMATCH REPAIR%WIKIPATHWAYS_20260810%WP531%HOMO SAPIENS DNA mismatch repair POLD3 POLD4 RFC3 RFC4 LIG1 RFC2 POLD2 RPA1 POLE MSH6 RPA3 RFC1 PMS2 POLE4 PCNA MSH2 POLE2 POLE3 T CELL RECEPTOR AND CO STIMULATORY SIGNALING%WIKIPATHWAYS_20260810%WP2583%HOMO SAPIENS T cell receptor and co stimulatory signaling NFKB1 CALM1 GSK3B PPP3CA DYRK2 CTLA4 PDCD1 DYRK1A IL2 CD8B ZAP70 CD8A ITK FYN LCK PLCG1 PTEN PTPN6 GSK3A PRKCA NFATC2 CSNK1A1 NFKBIA AMPK REGULATION OF MAMMARY MILK PROTEIN SYNTHESIS%WIKIPATHWAYS_20260810%WP5492%HOMO SAPIENS AMPK regulation of mammary milk protein synthesis EIF4A2 RPTOR EIF4G1 PRKAA2 EEF2 PRKAA1 CSN2 RPS6KB1 TSC2 CSN3 CSN1S1 PRKAB2 MTOR EEF2K MLST8 PRKAG1 PRKAG2 EIF4E PRKAB1 PRKAG3 TRANSLATION FACTORS%WIKIPATHWAYS_20260810%WP107%HOMO SAPIENS Translation factors EIF4G1 EIF2AK2 GSPT2 EEF2K EEF1B2 EIF4EBP1 EIF4H EIF4EBP3 EIF2B1 EIF4E EIF5A EIF5B EIF2B3 EIF6 CLUH EIF1AY EIF2AK1 EEF1G EEF1A2 ETF1 EIF4A2 PABPC1 EIF4A1 EIF2B2 EEF1A1 EIF1AX EIF4B EIF2S2 EEF2 EIF2S1 SUI1 EIF3S3 EIF4EBP2 EIF5 EIF2S3 EIF2B5 EIF3S2 EIF3J EIF3G EIF3CL EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PAIP1 GPCRS CLASS A RHODOPSIN LIKE%WIKIPATHWAYS_20260810%WP455%HOMO SAPIENS GPCRs class A rhodopsin like OR6A2 OR7C2 OR7C1 GPR19 OR10J1 GPR27 GPR25 PTGDR2 GPR22 BRS3 CCKAR OPN1LW CCR7 CCR6 CCR4 CXCR4 GPR39 OR5F1 GPR37 GPR34 AVPR1B GPR32 CHRM1 GPR31 AVPR1A OR5V1 OPN1MW MC1R ADRB3 OR3A2 MAS1 OPRD1 OR10H1 OR10H3 F2R GPR45 OR10H2 GPR42 OR2AG1 CHML GPR52 GPR50 GPR4 GPR3 GPR6 MC5R F2RL1 F2RL3 OR1C1 ADRB1 CHRM4 ADRB2 GPR65 CHRM5 GPR63 CCRL2 OR2D2 LHCGR NPY1R GPR83 OR2T1 OR1A2 OR1A1 OR2C1 SUCNR1 OR5I1 GPR85 MCHR1 OR2S2 HCAR3 OR1Q1 HRH1 RHO HCAR1 HRH3 TBXA2R HRH2 OR2B3 DRD5 OR2B2 HTR1E HTR1D HTR1B GPER NMUR2 NMUR1 OR7A10 OR14J1 PTGER4 MLNR PTGER1 HTR2B PTGER2 CHRM3 ADRA1B PTGER3 OR1G1 ADRA1A PRLHR OR8D2 ADRA1D OR7A17 PTGIR NPY5R GRPR OR2H2 AVPR2 OPRM1 EDNRA CHRM2 SSTR3 SSTR4 SSTR5 OR7A5 CCR5 OR10A4 CX3CR1 OR1E2 OR1F1 NPY4R OR2H1 CNR2 OR8B8 CXCR1 OR2W1 OR12D3 OR1D5 MAS1L OR1D2 CCKBR OR2F2 OPRK1 HTR5A OPN1SW ACKR4 ACKR2 OR11A1 OR3A3 OR10A5 OR3A1 PTGFR OR1E1 C5AR2 CXCR3 OR2B6 NTSR1 NMBR GPR17 HTR1F HTR1A OR2F1 OR2A4 GPR18 HTR2A SSTR2 NPY2R IL8RB HTR4 HTR6 HTR7 MTNR1A MTNR1B FFAR2 DRD1 DRD3 LPAR4 DRD4 OPN4 P2RY6 OPN3 P2RY4 P2RY2 P2RY1 P2RY13 P2RY10 P2RY11 P2RY14 ADORA2A ADORA2B BDKRB2 AGTR1 MC3R BDKRB1 AGTR2 CXCR5 C3AR1 FFAR3 HCRTR2 HCRTR1 GHSR MC4R GPR87 GPR68 FSHR F2RL2 ACKR3 KPG_011 CCR3 CCR2 ADRA2C ADRA2B ADRA2A FPR2 GPR75 LTB4R CMKLR1 CCR8 DRD2 FFAR1 NPFFR2 OXTR NPFFR1 RRH GPR174 GPR173 EDNRB GPR171 CMKLR2 PTGDR CNR1 GPR37L1 FPRL2 TRHR GPR161 FPR1 OR1I1 MC2R KPG_010 GALR3 GALR2 NPBWR1 GALR1 NPBWR2 OR6B1 CCR10 NTSR2 CCR1 XCR1 OR2J3 OR2J2 OR2J1 RGL4 BIOMARKERS FOR PYRIMIDINE METABOLISM DISORDERS%WIKIPATHWAYS_20260810%WP4584%HOMO SAPIENS Biomarkers for pyrimidine metabolism disorders HEL-S-29 RRM2B DPYS DPYD DHODH TYMP UMPS TYMS RRM1 RRM2 HEL74 NT5C3A PHOTODYNAMIC THERAPY INDUCED HIF 1 SURVIVAL SIGNALING%WIKIPATHWAYS_20260810%WP3614%HOMO SAPIENS Photodynamic therapy induced HIF 1 survival signaling PDHA1 BCL2L1 HEL-S-133P TGFA NOS2 HEL-S-68p BAK1 PFKL BIRC5 PMAIP1 BAX MCL1 EGLN1 EPO HIF1A EDN1 IGFBP1 BCL2A1 PTGS2 BNIP3L BNIP3 IGFBP2 VEGFA SLC2A3 ANGPT1 HEL-S-30 ANGPT2 HIF1AN SERINE METABOLISM%WIKIPATHWAYS_20260810%WP4688%HOMO SAPIENS Serine metabolism TYMS PSAT1 SHMT1 PHGDH HEL-S-51e PSPH DHFR MULTIPLE EPIPHYSEAL DYSPLASIA AND PSEUDOACHONDROPLASIA GENES%WIKIPATHWAYS_20260810%WP4789%HOMO SAPIENS Multiple epiphyseal dysplasia and pseudoachondroplasia genes MATN1 COL9A1 COL9A3 COMP COL9A2 MATN3 OVERLAP BETWEEN SIGNAL TRANSDUCTION PATHWAYS CONTRIBUTING TO LMNA LAMINOPATHIES%WIKIPATHWAYS_20260810%WP4879%HOMO SAPIENS Overlap between signal transduction pathways contributing to LMNA laminopathies RB1 PS1TP5BP1 KAT2B LEF1 CEBPD APC CSNK1A1L EMD WNT10B TCF7L2 LEMD3 TCF7L1 JUNB NOTCH1 BMP2 HMGA2 MSTN RUNX2 TNFRSF11B CSNK1A1 DICER1 MAOA CEBPA CDK4 CEBPB SMAD2 GSK3B HES1 HES5 ICMT WNT7B ZMPSTE24 TARBP2 FNTA LMNA AGO2 HDAC1 CREBBP PPARG AXIN1 TGFB1 opn CDKN1A CTSK MYOD1 DISORDERS OF FOLATE METABOLISM AND TRANSPORT%WIKIPATHWAYS_20260810%WP4259%HOMO SAPIENS Disorders of folate metabolism and transport MTHFD1 FOLR1 MTR MTHFD2 TYMS MTHFD2L SLC46A1 HEL-S-70p SHMT1 MTHFS HEL-S-51e SLC19A1 FTCD DHFR IRON SULFUR CLUSTER BIOGENESIS%WIKIPATHWAYS_20260810%WP5152%HOMO SAPIENS Iron sulfur cluster biogenesis FDX1 FDXR HSCB CIAO2B FXN ISCU NUBP1 NUBP2 NFU1 NARF LYRM4 ABCB7 TCA CYCLE IN SENESCENCE%WIKIPATHWAYS_20260810%WP5050%HOMO SAPIENS TCA cycle in senescence FH PDHA1 BRAF HEL-S-32 PDP2 ME2 ME1 ARYL HYDROCARBON RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2873%HOMO SAPIENS Aryl hydrocarbon receptor pathway IL12A IL1B CDKN1B CYP1A2 SRC POLK JUND UGT1A7 SLC7A5 TNF UGT1A4 MYOF CAP2 SERPINB2 IFNG BAX AHRR JUNB JUN NFE2L2 PTGES3 NQO1 UGT1A3 UGT1A1 CYP1A1 CYP1B1 UGT1A9 HES1 AHR IGFBP1 EGFR EP300 AIP ALDH3A1 NCOA1 CES3 IL2 CDC37 MGST1 TGFB1 IL17B IL12B HEMESYNTHESIS DEFECTS AND PORPHYRIAS%WIKIPATHWAYS_20260810%WP5169%HOMO SAPIENS Hemesynthesis defects and porphyrias ALAS1 ALAS2 FECH UROD UROS CPOX HMBS NUCLEOTIDE EXCISION REPAIR%WIKIPATHWAYS_20260810%WP4753%HOMO SAPIENS Nucleotide excision repair POLD3 POLD4 CDK7 RFC3 RFC4 LIG1 POLD2 RFC2 DDB2 RPA1 DDB1 RPA3 RFC1 CETN2 XPA POLE4 CCNH POLE2 ERCC1 CUL4B GTF2H2C_2 POLE3 XPC GTF2H2 GTF2H3 GTF2H4 ERCC2 RBX1 MNAT1 ERCC5 POLE PCNA CUL4A NOTCH SIGNALING%WIKIPATHWAYS_20260810%WP268%HOMO SAPIENS Notch signaling CTBP2 KAT2B MAML1 DTX1 DVL1 CTBP1 DVL2 DVL3 APH1B NOTCH3 RBPJL NOTCH4 NUMB DTX2 MAML3 DTX3 DTX4 DLL3 KCNJ5 DLL4 KAT2A LFNG MFNG NOTCH1 HES1 HES5 ADAM17 HDAC2 JAG2 PSEN2 HDAC1 NCOR2 CREBBP PSEN1 DTX3L NOTCH2 RBPJ IL23 INHIBITORS IN INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260810%WP5516%HOMO SAPIENS IL23 inhibitors in inflammatory bowel disease IL22 RORC TYK2 TLR4 CSF2 STAT1 TNF STAT3 IL17A STAT5B IFNG STAT4 IL23A IL17F IL12RB1 IL12B DISORDERS IN KETONE BODY SYNTHESIS%WIKIPATHWAYS_20260810%WP5175%HOMO SAPIENS Disorders in ketone body synthesis HMGCL BDH1 OXCT1 ACAT1 NEPHROGENESIS%WIKIPATHWAYS_20260810%WP5052%HOMO SAPIENS Nephrogenesis FOXD1 ALDH1A2 FGF8 FGF20 WNT3A WNT4 PAX2 SIX2 WNT9B NOTCH2 OSR1 TCF21 GREB1L MEIS1 BMP7 RSPO3 RSPO1 AUTOPHAGY%WIKIPATHWAYS_20260810%WP4923%HOMO SAPIENS Autophagy WIPI2 ATG14 PRKAA1 PRKAB2 MTOR PRKAG1 PRKAG2 RB1CC1 PIK3R4 PRKAB1 PRKAG3 ATG3 AKT1S1 DKFZp762B153 AMBRA1 DEPTOR UVRAG ATG101 RPTOR PRKAA2 ATG16L1 DKFZp686F0183 MLST8 ATG12 ATG9A ULK1 APOPTOSIS REGULATION BY PARATHYROID HORMONE RELATED PROTEIN%WIKIPATHWAYS_20260810%WP3872%HOMO SAPIENS Apoptosis regulation by parathyroid hormone related protein PTHLH BCL2L12 BCL2L13 BCL2L10 BCL2L1 BCL2L14 ITGB4 AKT3 GSK3B MYC ITGA6 BAK1 BCL2A1 BCL2L2 BOK BAX MCL1 BCL2 GSK3A SPHINGOLIPID METABOLISM OVERVIEW%WIKIPATHWAYS_20260810%WP4725%HOMO SAPIENS Sphingolipid metabolism overview CERS3 CERS6 CERK SGMS1 SGMS2 SGPP2 GBA2 SGPP1 LASS1 UGT8 UGCG SGPL1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 CERS2 SPHK2 SPHK1 SPTLC1 PLPP3 PLPP2 PLPP1 MITOCHONDRIAL IMMUNE RESPONSE TO SARS COV 2%WIKIPATHWAYS_20260810%WP5038%HOMO SAPIENS Mitochondrial immune response to SARS CoV 2 IFIH1 NFKB1 TRAF6 IRF7 TLR7 TMPRSS2 TLR3 TICAM1 ACE2 NFKB2 NDUFB9 AGTR1 CTSL REN AGTR2 MITA IKBKE TOMM70 PHB2 NLRX1 CGAS MAVS ECSIT ACAD9 NDUFAF1 RIGI TBK1 IRF3 TRAF3 LET 7 INHIBITION OF ES CELL REPROGRAMMING%WIKIPATHWAYS_20260810%WP3299%HOMO SAPIENS let 7 inhibition of ES cell reprogramming SOX2 MYC KLF4 EGR1 POU5F1 TRIM71 VITAMIN A1 AND A5 X PATHWAYS%WIKIPATHWAYS_20260810%WP5397%HOMO SAPIENS Vitamin A1 and A5 X pathways RXRG NR1B3 RARB RXRB RXRA RARA SEROTONIN AND ANXIETY RELATED EVENTS%WIKIPATHWAYS_20260810%WP3944%HOMO SAPIENS Serotonin and anxiety related events HTR1A HTR2A ARC CRH PLCD4 NLGN1 FOS PLEK PPP3CA PRKCB HAIR FOLLICLE DEVELOPMENT CYTODIFFERENTIATION STAGE 3 OF 3%WIKIPATHWAYS_20260810%WP2840%HOMO SAPIENS Hair follicle development cytodifferentiation stage 3 of 3 IGF1 NFKB1 LEF1 GPRC5D DKK4 FZD1 ELANE FOXE1 PERP NR3C1 ADAM17 EGFR TP63 SMAD4 SMAD1 NOTCH2 FOS RBPJ CD133 HR Nbla10317 HOXC12 FOXQ1 SOX2 CASP14 SOX9 SOSTDC1 KRTAP3-3 MSX2 PHLDA1 CD34 KRTAP15-1 SPINK6 SPINK5 ATL1-beta GTPBP4 ADAMTS20 DKK3 CTGF SFRP1 DSG1 GAS1 S100A4 DSC2 DSG4 GPR49 DLX3 IFNG KLK5 KLK4 KLK6 WIF1 LRIG1 NOTCH1 KRTAP6-1 JUN KRTAP2-4 MSX1 GSDMA KRTAP8-1 KLK13 KLK14 FOXN1 KRT19 GJB6 ZBTB16 CD200 IGFBP5 BMP6 TCF4 RUNX3 FST TCF3 DKK1 BMPR1A GATA3 EGR2 BMP4 FOSB NFATC1 KITLG PKC GAMMA CALCIUM SIGNALING IN ATAXIA%WIKIPATHWAYS_20260810%WP4760%HOMO SAPIENS PKC gamma calcium signaling in ataxia TRPC3 GNA14 HOMER3 CA8 GRIA2 PLCB3 PLCB4 GNA11 RYR3 PLCB1 ATP2B2 PLCB2 GRIA3 GRIA4 CACNA1A GNA15 G PROTEIN SIGNALING%WIKIPATHWAYS_20260810%WP35%HOMO SAPIENS G protein signaling GNGT1 PDE4D GNGT2 PRKCZ HRAS PRKD1 GNB3 PDE7B CALM1 GNAL NRAS GNA15 PDE7A RRAS GNB2 GNB5 GNB1 PRKACG GNAS PRKAR1A GNG3 GNG5 GNG4 ADCY3 GNA13 ADCY1 GNG7 ARHGEF1 GNG8 ADCY8 GNAZ AKAP8 ADCY6 ADCY5 GNA11 ADCY9 GNAO1 PRKCA GNAI3 GNAI1 GNA14 HEL159 AKAP12 AKAP5 AKAP10 AKAP11 PRKAR1B AKAP9 AKAP7 PPP3CA PRKCB PLCB3 AKAP6 AKAP4 KCNJ3 PPP3CC ARHA PRKCI PDE1C PRKCH PDE1B PDE1A PRKCE PDE4B PDE8A GNG10 PDE4A GNG12 GNG11 PRKD3 PRKCQ GNG13 TRANSCRIPTIONAL ACTIVATION BY NRF2 IN RESPONSE TO PHYTOCHEMICALS%WIKIPATHWAYS_20260810%WP3%HOMO SAPIENS Transcriptional activation by NRF2 in response to phytochemicals NQO1 SLC7A11 HMOX1 GCLC GCLM CEBPB EPHB2 MAPK8 MAF NFE2L2 KEAP1 PRKCA AIMP2 DIET DEPENDENT TRIMETHYLAMINE TRIMETHYLAMINE N OXIDE METABOLISM %WIKIPATHWAYS_20260810%WP5219%HOMO SAPIENS Diet dependent trimethylamine trimethylamine N oxide metabolism SLC44A1 ALDH7A1 CHDH SULFATASE AND AROMATASE PATHWAY%WIKIPATHWAYS_20260810%WP5368%HOMO SAPIENS Sulfatase and aromatase pathway SULT1E1 SLCO4A1 SLCO4C1 SLCO2B1 HSD17B1 SLCO1A2 HSD17B2 HSD3B1 HSD17B3 NR3A2 SLCO1B1 SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260810%WP4658%HOMO SAPIENS Small cell lung cancer NFKB1 POLK APAF1 DDB2 E2F2 BAK1 PTEN BAX TRAF4 LAMB2 LAMA4 ITGAV COL4A6 ITGB1 NFKBIA LAMC1 COL4A2 COL4A1 PTGS2 CDKN2B CCND1 CASP8 MAX BIRC2 BIRC3 SKP1 CASP9 TRAF3 RB1 TRAF6 CDKN1B BCL2L1 NOS2 PIK3CD PIK3R3 E2F3 RELA PIK3R2 CASP3 CCNE2 PIK3R1 CCNE1 RXRB RXRA ITGA2B TRAF5 GADD45B GADD45A CDKN1C RXRG GADD45G TRAF1 CDK6 ITGA2 LAMA1 CDK4 AKT3 LAMA3 CDK2 LAMC2 LAMB3 MYC ITGA6 LAMB1 IKBKB TRAF2 IKBKG RARB COL4A4 CKS1B COL4A3 CKS2 COL4A5 BIRC7 FHIT LAMB4 CHUK BCL2 LAMA5 CYCS NFKBIB CDKN1A 17Q12 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5287%HOMO SAPIENS 17q12 copy number variation syndrome TBC1D3I PIGW AATF IKZF3 CISD3 TBC1D3H PPP1R1B CCT6B RDM1 ARL5C C17orf50 GPR179 STARD3 CCL11 UNC45B MED1 SLC35G3 RPL23 SRCIN1 FNDC8 SLFN12 DUSP14 SLFN13 RAD51D TBC1D3 SLFN11 SLFN14 ZNF830 CCL14 SLFN5 CCL13 GGNBP2 MMP28 CCL3L3 FBXO47 MLLT6 FBXL20 NEUROD2 MIEN1 CCL8 PIP4K2B MRM1 CCL7 ZNHIT3 C17orf78 CCL1 ASIC2 RFFL CCL18 GAS2L2 SOCS7 CCL16 HEATR9 CCL15 TAF15 TMEM132E ERBB2 RASL10B PCGF2 ACACA SYNRG EPOP PEX12 PLXDC1 NLE1 ARHGAP23 HEL-S-6a TBC1D3K TCAP TEC STAC2 CDK12 SPMAP1 TCF2 CACNB1 CCL5 CCL4 CCL3 CCL2 PNMT LHX1 GRB7 DHRS11 TBC1D3B CCL4L2 TBC1D3E TBC1D3C PGAP3 CWC25 VITAMIN A AND CAROTENOID METABOLISM%WIKIPATHWAYS_20260810%WP716%HOMO SAPIENS Vitamin A and carotenoid metabolism RDH8 ALDH1A3 RETSAT CRABP1 ALDH1A2 RLBP1 CYP26B1 CYP2E1 HEL-S-4 DHRS3 SULT2B1 CYP26A1 RBP7 RBP2 SULT1A1 RBP1 RDH5 ABCG8 ABCG5 RXRB NPC1L1 MAPK1 RXRA CD36 DGAT1 RXRG RBP4 RPE65 SDR16C5 RDH12 AWAT2 NR1B3 LRAT BCO1 RARB ADH1A SCARB1 RDH10 LPL HEL-S-53e RARA CRABP2 INTEGRATED BREAST CANCER PATHWAY%WIKIPATHWAYS_20260810%WP1984%HOMO SAPIENS Integrated breast cancer pathway NFKB1 TGFBR1 CDK7 CDC42 STAT1 PAK1 RALA JAK1 STK11 XRCC3 GSK3A SP1 BACH1 UBE2F GRN EGFR NUP85 CCND1 TPR RAP1A SMAD4 CREB1 FOXO1 CASP9 RHO RHEB SMEK1 TSC2 ZMYND8 TSC1 NAB1 PIK3R2 MAP3K7CL ZMIZ1 ALKBH1 MTOR RPP38 RALGAPA1 MAPK1 PPP4R3B CCNB1IP1 CDC25B EDAR LGALS13 BLM MYCBP2 PLK3 IRS1 APOBEC3G ERAL1 FOSL2 FER PKIA NOXA1 ZNF655 PIGR GDI1 DHTKD1 ARAF RASGEF1A ANXA1 DCAKD MYC ITPKC USP15 EP300 USP16 SELENOK USP21 WEE1 FILIP1 FAU VEGFA SIRT1 BRAF BCL2 AURKA BRCA2 TGFBR2 BAK1 MYT1 BAD PTEN BAX MSH2 FADD PLK1 FOSL1 SMAD6 MAP3K13 CERK AHR RASGRP3 RRAS ATF1 MAX CASP8 HDAC1 CSNK1D SMAD1 BARD1 RB1 HIPK2 CHEK2 CHEK1 MSH6 PIAS1 CASP3 RAC1 SMARCA4 MAP3K7IP1 JUN GADD45A MRE11A PML RAD50 RAD51 DAG1 CDK4 SMAD2 CDK2 MDM2 ATM TRADD ATR BMPR1A NF1 TFPI CHUK HMGCR NRP1 TRIGGERED SIGNALING IN PANCREATIC CANCER %WIKIPATHWAYS_20260810%WP5144%HOMO SAPIENS NRP1 triggered signaling in pancreatic cancer NFKB1 CDKN1B TGFBR1 SRC MAP2K1 MMP9 MAP2K2 TGFBR2 CTGF RELA CCNE2 KDR CCNE1 MAPK1 PLXNA2 RAC1 MAPK3 GSK3A NFKB2 TGFBR3 FLT1 PECAM1 COL1A1 SNAI1 COL1A2 AKT3 SMAD2 CDK2 CHD2 HGF EGFR RELB MMP2 PLXNA1 SEMA3A PLXNA4 VEGFA NRP1 SMAD4 REL SNAI2 EGF MOLYBDENUM COFACTOR MOCO BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP4507%HOMO SAPIENS Molybdenum cofactor Moco biosynthesis AOX1 MOCS2 MTARC2 SUOX XDH MOCS1 GPHN PATHOPHYSIOLOGICAL ROLES OF DUX4 IN FSHD1%WIKIPATHWAYS_20260810%WP5342%HOMO SAPIENS Pathophysiological roles of DUX4 in FSHD1 FBXO32 MYF5 RET MYC ADRB2 PAX7 EP300 MYOG VEGFA TRIM63 PPARGC1A H3Y1 H3Y2 DUX4 NR3A2 CDKN1A MYOD1 SARS COV 2 MITOCHONDRIAL CHRONIC OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260810%WP5183%HOMO SAPIENS SARS CoV 2 mitochondrial chronic oxidative stress and endothelial dysfunction NFKB1 TRAF6 NLRP3 REN RPS6KA1 IL18 TNF SIRT6 MITA ACE2 TOMM70 TERF2 IL6 NLRX1 MAVS ECSIT ACAD9 NDUFAF1 NDUFAF2 TERF2IP TRAF3 TRANSCRIPTIONAL CASCADE REGULATING ADIPOGENESIS%WIKIPATHWAYS_20260810%WP4211%HOMO SAPIENS Transcriptional cascade regulating adipogenesis EGR2 GATA3 CEBPD DDIT3 PPARG GATA2 CEBPA CEBPB KLF2 KLF5 CEBPG KLF15 MICRORNA NETWORK ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA%WIKIPATHWAYS_20260810%WP4399%HOMO SAPIENS MicroRNA network associated with chronic lymphocytic leukemia ZAP70 MCL1 BCL2 RENIN ANGIOTENSIN ALDOSTERONE SYSTEM RAAS %WIKIPATHWAYS_20260810%WP4756%HOMO SAPIENS Renin angiotensin aldosterone system RAAS CTSG CAMK2G CAMK1D CAMK1G CALM1 CAMK4 CREB3 CREB5 ATF6B AGTR1 REN AGTR2 CREB3L3 CAMK2D CREB3L4 CAMK2A CREB3L2 ATF1 CMA1 ATF2 ATF4 ITPR2 CAMK1 HSD3B2 PLCB2 HSD3B1 CREB1 CALML6 CALML3 CALML4 STAR CYP11B2 CYP21A2 CYP11A1 NAD METABOLISM SIRTUINS AND AGING%WIKIPATHWAYS_20260810%WP3630%HOMO SAPIENS NAD metabolism sirtuins and aging NFKB1 FOXO3A TFAM PPARG SIRT1 SIRT3 NAMPT PARP1 HIF1A FOXO1 ROS1 INFLAMMATORY BOWEL DISEASE SIGNALING%WIKIPATHWAYS_20260810%WP5198%HOMO SAPIENS Inflammatory bowel disease signaling IL12A NFKB1 IL5 IL18RAP TBX21 IL21R TLR5 TLR4 TNF STAT1 IL18 STAT3 IL4 STAT4 IFNG IL10 IFNGR1 IL13 JUN RORA IL22 IL1A IL-21 RORC SMAD2 IL23R MAF GATA3 IL2 HLA-DMA NFATC1 IL23A IL6 IL17F TGFB1 NOD2 IL12RB1 FOXP3 IL2RG MULTIPLE SCLEROSIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260810%WP5540%HOMO SAPIENS Multiple sclerosis mechanism and therapies S1PR1 S1PR3 ITGA4 S1PR5 HEL-S-171mP S1PR4 MS4A1 ITGB1 BTK KYNURENINE PATHWAY AND LINKS TO CELL SENESCENCE%WIKIPATHWAYS_20260810%WP5044%HOMO SAPIENS Kynurenine pathway and links to cell senescence AHR TLR4 AADAT TNF HEL-S-90n HAAO IL1R2 EIF2AK4 KMO TDO2 KYNU AFMID IFNB1 IFNG IDO2 IDO1 EIF2AK1 FOXO1 CDKN1A KLF5 INTEGRATIVE ANALYSIS OF TREG GLIAL INTERACTIONS %WIKIPATHWAYS_20260810%WP5561%HOMO SAPIENS Integrative Analysis of Treg Glial Interactions IL12A IGF1 NFKB1 TGFBR1 JAK3 TYK2 MMP9 CNP TGFBR2 CDC42 STAT1 OSM STAT3 CCR6 MOG IL4 STAT4 IKZF2 CCN3 JAK1 NKX6-2 PDGFRA CD47 EBI3 SSTR2 AIF1 APOD ITGB3 NKX6-1 ITGAV TGFBR3 KLRG1 NFKB2 GSDMD IL33 MCAM TMEM119 CSPG4 MYD88 CXCL1 CD68 FOXO4 CCL1 IGF1R CCR8 EGFR FAM20C ROS1 HTR7 IL2 SOCS3 CCL20 AREG opn SIRPA FOXO1 FOXP3 IL10RB IL2RG IL10RA IL1B SOX9 TNFRSF1B NLRP3 IL2RA IL2RB CXCL12 OLIG1 OLIG2 TLR4 NOS2 TNF IL18 PDCD1 IFNG RAC1 HEL-S-111 IL10 MBP PDGFA CX3CR1 MAPK14 ITGA2 SMAD2 CTLA4 STAT5B FOXO3A VEGFA IL6 TGFB1 CD80 IL12RB1 NKX2-2 CD44 SARS COV 2 AND ACE2 RECEPTOR MOLECULAR MECHANISMS%WIKIPATHWAYS_20260810%WP4883%HOMO SAPIENS SARS CoV 2 and ACE2 receptor molecular mechanisms ACE2 AGTR1 REN TMPRSS2 MAS1 CONSTITUTIVE ANDROSTANE RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2875%HOMO SAPIENS Constitutive androstane receptor pathway CYP2C19 SULT1A1 UGT1A4 NCOA6 PTPA SMC1A SULT2A1 CYP2C9 RXRA ABCC3 CYP2B6 ABCC2 CYP2A6 DNAJC7 UGT1A3 UGT1A1 UGT1A9 SP1 NR1I3 CYP3A4 EHHADH NCOA1 CYP4A11 PPARGC1A ALAS1 ABCB1 FOXO1 NO CGMP PKG MEDIATED NEUROPROTECTION%WIKIPATHWAYS_20260810%WP4008%HOMO SAPIENS NO cGMP PKG mediated neuroprotection IL1B CAMK2G PDE2A NFKB1 GRIN2B PDE3A CALM1 NOS2 TNF RELA IFNG BAD NFKBIA NPPB CNGA1 CNGA3 GUCY1B1 CNGA4 PBR CAMK2D CNGB3 CAMK2A CNGB1 AKAP9 GRIN1 NPPA NEFL DLG4 ACTN2 CREB1 BCL2 CYCS GUCY1A2 CASP9 EICOSANOID METABOLISM VIA CYCLOOXYGENASES COX %WIKIPATHWAYS_20260810%WP4719%HOMO SAPIENS Eicosanoid metabolism via cyclooxygenases COX TBXA2R ACOX1 PTGS1 PTGDR2 PTGIS PLA2G4B PLA2G5 PLA2G6 PTGIR PRXL2B PTGES NR1C2 PTGR1 EHHADH PTGDR HEL-S-298 HPGD AKR1B1 PTGS2 ACOX3 CYP4F2 CYP4A11 CYP4A22 PPARG PTGFR CYP4F12 PROXIMAL TUBULE TRANSPORT%WIKIPATHWAYS_20260810%WP4917%HOMO SAPIENS Proximal tubule transport SLC16A10 ATP1B1 HEL-76 SLC7A9 FXYD2 ATP6V0D2 ATP6V0C ATP6V1B1 ATP6V0E1 ABCC2 SLC34A1 SLC22A7 ATP6V1C1 ABCG2 SLC2A2 ATP6V1F SLC34A3 SLC6A18 SLC9A3 SLC5A5 SLC5A8 SLC47A2 ATP6V1A SLC22A6 SLC47A1 SLC3A1 SLC1A1 SLC3A2 ATP1A1 SLC6A19 SLC7A7 SLC4A4 SLC5A1 AQP1 CLTRN SLC5A2 CA4 SLC6A20 ATP6V0A4 ATP6V1E1 ATP6V1G1 ATP6V1D ABCB1 SLC22A11 ATP6V0B SLC36A2 B CELL RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP23%HOMO SAPIENS B cell receptor signaling NFKB1 HRAS BCL6 CDC42 VAV1 VAV2 BTK SOS1 BLK STM7 GSK3A LYN NFKBIA RAPGEF1 PIP5K1C CRKL CAMK2A RASGRP3 ATF2 PIP5K1A MAX SHC1 CD81 PLCG2 REL SYK PLCG1 CREB1 TEC FOXO1 MAP2K1 LAT2 HCLS1 MAP2K2 DAPP1 BASH CD79B CD79A RELA CD19 PIK3R2 MAPK9 PTPN18 PIK3R1 PIK3AP1 INPP5D CD22 GTF2I MAPK1 RAF1 FYN RAC1 MAP2K6 JUN PTPN6 PTPN11 MAPK14 MAPK4 RPS6KA1 GSK3B NCK1 MYC IKBKB PRKCB MAPK8 CBL IKBKG CR2 CRK MAP3K7 NFATC3 MAP4K1 LCK BRAF CARD11 CHUK BCL10 PDPK1 GRB2 NFATC2 PTPRC GAB2 MYOMETRIAL RELAXATION AND CONTRACTION PATHWAYS%WIKIPATHWAYS_20260810%WP289%HOMO SAPIENS Myometrial relaxation and contraction pathways GNGT1 PDE4D NFKB1 PRKD1 CALM1 OXT RYR3 ACTA2 DKFZp686L0365 DGKZ SP1 CAMK2A ADM GNB2 GNB1 GNB4 ITPR2 PLCG2 PLCG1 ATP2A2 CREB1 PRKAR1A GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CACNB3 ACKR3 RAMP1 ATF3 HEL2 GJA1 PKIA IGFBP5 CALCA RGS16 PRKAR1B RYR1 PRKCB PLCB3 ACTG1 ATF4 HEL-S-93 IGFBP2 PRKCH PRKCE IL6 MYL4 ACTA1 PRKCQ MYL2 CAMK2G YWHAQ HEL-S-1 PRKCZ GNB3 MYLK2 RYR2 CREB3 SLC8A1 ATF6B YWHAG ETS2 RGS2 IGFBP1 ATF1 ATF2 GNB5 RGS14 GNAS MAFF FOS ATF5 PS1TP5BP1 IL1B ADCY3 ADCY1 ADCY8 ADCY6 ADCY5 CRCP RXFP2 GABPB1 RGS4 ADCY9 RGS5 RGS1 RGS6 IGFBP4 SFN GABPA HEL-S-14 JUN CNN2 GRK5 GRK4 PRKCA CALD1 IGFBP6 PKIB RLN1 PKIG OXTR HEL-S-21 RGS18 RGS17 RAMP2 RAMP3 RGS20 CRH CORIN CAMK2D GUCA2B GUCA2A RGS11 ACKR5 PDE4B GNG12 GNG11 LPAR1 GNG13 RGS10 GROWTH FACTORS AND HORMONES IN BETA CELL PROLIFERATION%WIKIPATHWAYS_20260810%WP5385%HOMO SAPIENS Growth factors and hormones in beta cell proliferation IGF1 FLT1 TGFBR1 CDK4 IGF1R AKT3 CDK2 MYC PDX1 RAB43 FOXM1 CRTC2 MAPK1 BRAF INSR MAPK3 PDGFA RASSF1 FOXO1 INS TUMOR SUPPRESSOR ACTIVITY OF SMARCB1%WIKIPATHWAYS_20260810%WP4204%HOMO SAPIENS Tumor suppressor activity of SMARCB1 RB1 EZH2 SMARCA4 SUZ12 ARID1A RBBP4 EED CDK6 CDK4 SMO SMARCD1 SMARCD2 SMARCD3 CDKN2A GLI4 ACTL6B DPF1 DPF2 DPF3 SMARCE1 SMARCC1 GLI3 SMARCC2 PTCH1 ARID1B H3F3B ACTL6A KETOGENESIS AND KETOLYSIS%WIKIPATHWAYS_20260810%WP4742%HOMO SAPIENS Ketogenesis and ketolysis BDH1 OXCT1 UCP2 SLC25A20 ACAT1 CPT2 HIPK2 IN KIDNEY FIBROSIS%WIKIPATHWAYS_20260810%WP4751%HOMO SAPIENS HIPK2 in kidney fibrosis HIPK2 SIAH1 CHOLESTASIS%WIKIPATHWAYS_20260810%WP5238%HOMO SAPIENS Cholestasis ABCC2 EPHX1 LDLR NR1I3 ABCB11 ABCG8 ABCG5 ABCB4 NR1H4 SLCO1A2 SCARB1 RXRA ABCC3 HMGCR ATP8B1 SLC22A1 LIDOCAINE METABOLISM%WIKIPATHWAYS_20260810%WP2646%HOMO SAPIENS Lidocaine metabolism CYP1A2 CYP3A4 ALTERNATIVE PATHWAY OF FETAL ANDROGEN SYNTHESIS%WIKIPATHWAYS_20260810%WP4524%HOMO SAPIENS Alternative pathway of fetal androgen synthesis AKR1C2 HSD3B2 AKR1C4 SRD5A2 HSD17B3 CYP17A1 POR STAR CYP11A1 HSD17B6 7 OXO C AND 7 BETA HC PATHWAYS%WIKIPATHWAYS_20260810%WP5064%HOMO SAPIENS 7 oxo C and 7 beta HC pathways ACOT9 ACOT8 ACOT7 ACOT11 ACOT12 ACOT13 EBP AMACR THEM5 SLC27A5 ACOT6 NPC1 SLC27A2 NPC2 ACOT4 CYP7A1 EPHX2 CYP27A1 BAAT HSD11B1 DHCR7 HSD11B2 DBP QUERCETIN AND NF KB AP 1 INDUCED APOPTOSIS%WIKIPATHWAYS_20260810%WP2435%HOMO SAPIENS Quercetin and Nf kB AP 1 induced apoptosis CYP2A6 NFKB1 MAFK IKBKB PTGS2 VEGFA MAFG JUN FOS COX1 NFE2L2 KEAP1 NFKBIA FOXA2 PATHWAY%WIKIPATHWAYS_20260810%WP5066%HOMO SAPIENS FOXA2 pathway ABCC2 APOB FOXA2 SLC27A5 FASN FOXA1 ACACA ABCC3 MTTP MLXIPL PPARGC1B GSTM2 IRS1 FOXO1 INS SLCO1B1 PATHOGENIC ESCHERICHIA COLI INFECTION%WIKIPATHWAYS_20260810%WP2272%HOMO SAPIENS Pathogenic Escherichia coli infection PS1TP5BP1 YWHAQ TUBAL3 TLR5 HCLS1 TLR4 WASL CDC42 ARPC1B ARPC4 ARPC5 HEL-68 KRT18 ARPC2 TUBA1C ARPC3 TUBA1B EZR LY96 FYN TUBB TUBB2A CD14 TUBA3E NCL PRKCA ITGB1 TUBB4B TUBB4A ROCK1 CLDN1 TUBB8 TUBB6 NCK1 ROCK2 TUBB1 TUBA4A ACTG1 ARHA ARHGEF2 HEL-S-93 WAS TUBA1A TUBA2 TUBA8 NCK2 METABOLIC EPILEPTIC DISORDERS%WIKIPATHWAYS_20260810%WP5355%HOMO SAPIENS Metabolic epileptic disorders DLAT G6PC1 SPCS1 PDHA1 PCK1 GOT2 HEL-S-133P ENO1 GPHN PSAT1 HEL-S-68p PHGDH SLC25A1 AADAT GLUD1 PSPH PFKL ENO2 ENO3 DLD AMT ALDOB MOCS3 GLDC MPC1 HK3 MPC2 AASS HEL-S-49 HEL-S-20 PGAM1 SHMT1 PFKP PGAM2 HEL-S-51e ACAT1 ETHE1 FBP1 CBS FBP2 SLC7A2 SQOR CTH HEL-S-87p MDH2 CDO1 GCK PFKM ECHS1 GCDH SLC2A3 ALDH7A1 SLC2A4 SLC25A5 SFXN1 ARG1 HEL-S-281 BTD ASS1 SLC25A15 PC ASL HLCS OTC HEL-S-162eP DHTKD1 SLC2A2 PKLR HEL60 MOCS2 SUOX HEL-S-32 XDH MOCS1 GLS2 HEL-S-30 GPT HK2 NUCLEAR RECEPTORS%WIKIPATHWAYS_20260810%WP170%HOMO SAPIENS Nuclear receptors NR1D2 PGR NR1H3 NR2F6 NR1i1 RXRB NR1i2 NR1C1 RXRA ESRRB NR1C2 RORA RXRG THRA NR2E1 NR2C2 ESRRA NR1I3 NR2F1 NR2F2 NR1A2 NR0B1 RORC NR5A1 HNF4A NR5A2 ROR1 NR3C1 NR1B3 NR1H2 RARB PPARG NR3A2 RARA ETHYLMALONIC ENCEPHALOPATHY%WIKIPATHWAYS_20260810%WP5030%HOMO SAPIENS Ethylmalonic encephalopathy SUOX ETHE1 PRO SURVIVAL SIGNALING OF NEUROPROTECTIN D1%WIKIPATHWAYS_20260810%WP5182%HOMO SAPIENS Pro survival signaling of neuroprotectin D1 TNFRSF1A RIPK3 TRADD TNF TRAF2 CASP3 CASP8 BAX RIPK1 BIRC3 FADD CYCS CASP9 REGULATORY CIRCUITS OF STAT3 SIGNALING%WIKIPATHWAYS_20260810%WP4538%HOMO SAPIENS Regulatory circuits of STAT3 signaling IFNAR2 JAK3 OSMR IL21R TYK2 STAT3 IL20RA IL20RB IFNAR1 CSF3R GHR JAK1 IFNGR1 PDGFRA IFNGR2 AKT1S1 F2R CSF2RB F2RL3 PTPRT CNTFR EGFR SETD7 MPL IL27RA IL15RA DUSP2 IL7R MLST8 IL9R CSF2RA SOCS3 CREBBP IFNLR1 MAPK15 IL22RA1 IL11RA IL6ST IL3RA IL5RA IL10RB IL2RG IL10RA IL2RA IL2RB SRC TRIM28 MAPK9 F2RL2 MTOR MAPK1 MAPK12 MAPK13 MAPK10 MAPK11 MAPK3 CTF1 MAPKAP1 DEPTOR RICTOR MAPK14 RPTOR AGTR1 MAPK6 MAPK4 AGTR2 IL6R PRKCB MAPK8 MAPK7 PTPRC FACT COMPLEX AND DNA DOUBLE STRAND BREAK REPAIR%WIKIPATHWAYS_20260810%WP5564%HOMO SAPIENS FACT complex and DNA double strand break repair MDC1 SETD2 HIST1H4L TP53BP1 XRCC5 RAD51 RNF8 ATM NBN PRKDC SUPT16H SSRP1 H1-1 RNF168 NASP H4C9 GENES RELATED TO PRIMARY CILIUM DEVELOPMENT BASED ON CRISPR %WIKIPATHWAYS_20260810%WP4536%HOMO SAPIENS Genes related to primary cilium development based on CRISPR CEP192 BBS4 TRAF3IP1 KIAA0753 KIF3A OFD1 CEP20 RAB23 TTC26 TTC23 C2CD3 CEP19 DYNC2H1 DYNC2I2 IFT172 CBY1 EFCAB7 DYNLT1 TXNDC15 IFT140 IFT52 TCTN3 DYNLT2B TCTN2 IFT80 TMEM107 TCTN1 WDR35 CDK20 DYNC2LI1 TRAPPC11 BBS9 BBS7 KIFAP3 IFT43 CEP97 IFT81 IFT57 IFT27 CC2D2A BBS5 DNCL1 CEP295 IFT46 ARMC9 RPGRIP1L IFT25 LZTFL1 BBS10 EVC BBS12 TMEM216 CCDC41 WDPCP TEDC1 CEP104 IFT70B TEDC2 ARL6 ARL3 FBF1 KATNB1 TUBD1 IFT74 ARL13B KIF3B TMEM67 INPP5E CEP76 PIBF1 EVC2 BBS2 MKS1 BBS1 SCLT1 RABL2B CPLANE1 TUBE1 FUZ CPLANE2 MIB1 TMEM231 IFT20 TTC8 TMEM17 SASS6 CEP162 B9D1 CIBAR1 CLUAP1 CEP44 DEREGULATION OF RAB AND RAB EFFECTOR GENES IN BLADDER CANCER%WIKIPATHWAYS_20260810%WP2291%HOMO SAPIENS Deregulation of Rab and Rab effector genes in bladder cancer RPH3A MADD SYTL1 MYRIP SYTL5 UNC13D TBC1D10A SYTL2 EXPH5 RAB27A MLPH RAB27B MICRORNAS IN CARDIOMYOCYTE HYPERTROPHY%WIKIPATHWAYS_20260810%WP1544%HOMO SAPIENS MicroRNAs in cardiomyocyte hypertrophy IGF1 NFKB1 LRP5 CDK9 CDK7 CISH LRP6 CALM1 MAP3K14 FGFR2 DVL1 STAT3 MYLK FZD1 FZD2 NPPB IGF1R HDAC5 EIF2B5 GATA4 HDAC7 MYLK3 IL6ST MAP2K3 MAP2K1 MAP2K2 PIK3CD TNF PIK3R3 LIF PIK3R2 PIK3R1 MTOR MAPK1 RAF1 RAC1 MAP2K6 MAP3K7IP1 MAPK3 CTF1 MAPK14 EDN1 ROCK1 MAPK4 GSK3B CAMK2D ROCK2 WNT3A FGF2 IKBKB PPP3CA PRKCB MAPK8 MAPK7 NPPA ARHA IKBKG IKBKE PRKG1 PLCB2 MAP2K5 MAP2K4 NFATC4 TGFB1 CHUK EGF RCAN1 PDPK1 PLA2G2A MYEF2 NRG1 PROLACTIN SIGNALING%WIKIPATHWAYS_20260810%WP2037%HOMO SAPIENS Prolactin signaling NFKB1 HRAS CISH HEL-S-130P HEL-S-69p NEK3 STAT1 PAK1 STAT3 VAV1 VAV2 SOS1 YWHAG SOCS1 JAK1 ITGB1 NFKBIA FLNA PRL SHC1 ERBB2 PTPN1 SOCS3 PRLR FOS TEC SIRPA SRC MAP2K1 AGAP2 MAP2K2 RELA PIK3R2 MAPK9 CASP3 PIK3R1 SOCS2 MTOR EIF4EBP1 MAPK1 RAF1 FYN RAC1 JUN MAPK3 PTPN6 IRS1 PTPN11 MAPK14 RPS6KA2 GSK3B MYC RPS6 RPS6KB1 MAPK8 CBL HEL-S-93 STAT5B ZAP70 PXN GRB2 NFKBIB PPIB GAB2 REGULATION OF WNT B CATENIN SIGNALING BY SMALL MOLECULE COMPOUNDS%WIKIPATHWAYS_20260810%WP3664%HOMO SAPIENS Regulation of Wnt B catenin signaling by small molecule compounds LEF1 FZD8 TNKS TCF4 WNT1 GSK3B APC SFRP4 DVL2 MBOAT1 DKK3 FZD1 FZD7 AXIN1 CSNK1A1 HIF1A AND PPARG IN HYPERTROPHIC CARDIOMYOPATHY%WIKIPATHWAYS_20260810%WP2456%HOMO SAPIENS HIF1A and PPARG in hypertrophic cardiomyopathy HEL-S-162eP GPD1 PPARG HEL-S-133P CD36 HEL-S-49 HMFN0839 HIF1A COMPLEMENT MEDIATED INFLAMMATION OF PULMONARY ALVEOLUS IN COVID 19 HYPOTHETICAL PATHWAY %WIKIPATHWAYS_20260810%WP5148%HOMO SAPIENS Complement mediated inflammation of pulmonary alveolus in COVID 19 hypothetical pathway C3AR1 ACE2 C5AR1 C8A C6 FCN1 C7 HEL-S-62p COLEC11 C9 MASP2 OSTEOBLAST DIFFERENTIATION AND RELATED DISEASES%WIKIPATHWAYS_20260810%WP4787%HOMO SAPIENS Osteoblast differentiation and related diseases LRP5 PRKCZ PRKD1 LRP6 FGFR2 STAT1 WNT3 HES6 WNT4 IHH FZD1 WNT9A WNT10B WNT8B HES3 WNT10A HES2 FZD3 FZD2 PIK3R5 FGF3 FZD7 FGF6 PIK3R4 FZD9 WNT7A BMP2 PIK3C2G FGF9 RUNX2 PIK3C2B DKFZp781O1323 FGF18 JAG2 SMAD4 SMAD1 SMAD9 NOTCH2 RBPJ FGFR1 MYOD1 HEY2 SOX9 PIK3CD PIK3R3 NOTCH3 PIK3R2 MAPK9 PIK3R1 NOTCH4 WNT8A PRKDC MAPK1 FGF7 DLL3 MAPK12 DLL4 MAPK13 MAPK10 WNT2B NOTCH1 MAPK11 MAPK3 PRKCA FGF4 FZD5 MAPK14 FZD4 FGF8 MAPK6 FZD8 MAPK4 WNT1 SMO WNT3A FGF2 FZD10 WNT7B PRKCB MAPK8 MAPK7 BMPR1A PRKCI PRKCH PPARG BMP4 WNT5B PRKCE GLI3 WNT9B PTCH1 FGF10 WNT16 FGFR4 FGFR3 PRKCQ GLYCINE METABOLISM INCLUDING IMDS%WIKIPATHWAYS_20260810%WP5028%HOMO SAPIENS Glycine metabolism including IMDs HSCB ISCU DLD AMT LIPT2 LIPT1 GLDC HEL-S-302 LIAS GCSH BOLA3 SHMT1 NFU1 EPO RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP581%HOMO SAPIENS EPO receptor signaling SRC CISH MAP2K1 MAP2K2 STAT1 STAT3 SOS1 SHC1 STAT5B MAPK1 SOCS1 RAF1 PTPRU EPOR MAPK3 EPO GRB2 IRS1 PTPRC PROSTAGLANDIN SIGNALING%WIKIPATHWAYS_20260810%WP5088%HOMO SAPIENS Prostaglandin signaling IL12A IL1B NFKB1 NLRP3 IRF7 MMP9 TNF PTGER4 PTGER2 CCL3 CCL2 IFNG PTGES CSF1 KLRD1 CCR2 CXCL1 IL1A CXCL9 AHR CXCL8 IFNA1 IL17A VEGFA IL6 IL17F TGFB1 AREG PYCARD G13 SIGNALING%WIKIPATHWAYS_20260810%WP524%HOMO SAPIENS G13 signaling GNA13 ARHGDIB ARHGEF1 CYFIP1 CFL2 CALM1 LIMK1 WASL HEL-S-15 PIK3CD CDC42 PIK3R2 RAC1 MAPK10 RTKN SH3RF1 TNK2 RHPN2 MYBPH CIT HEL-S-80p PFN1 PIP4K2A ROCK1 ROCK2 RPS6KB1 ARHA PKN1 WAS IQGAP1 ARHGDIG MYL1 NSAIDS MECHANISM OF ACTION%WIKIPATHWAYS_20260810%WP5513%HOMO SAPIENS NSAIDs mechanism of action PTGS1 PTGS2 COVID 19 THROMBOSIS AND ANTICOAGULATION%WIKIPATHWAYS_20260810%WP4927%HOMO SAPIENS COVID 19 thrombosis and anticoagulation FGA F13B PLG F13A1 HEL-S-78p F2 PROSTAGLANDIN AND LEUKOTRIENE METABOLISM IN SENESCENCE %WIKIPATHWAYS_20260810%WP5122%HOMO SAPIENS Prostaglandin and leukotriene metabolism in senescence RB1 ADCY3 PTGS1 HRAS PTGIS PTGER4 PTGER1 ALOX15 PTGER2 ALOX12 ALOX5 PTGER3 LTC4S NRAS ALOX15B PRXL2B ALOX5AP PTGES MAPK11 GNAI1 IGFBP5 PTGS2 GNAS SIRT1 CDKN1A INTERACTIONS BETWEEN IMMUNE CELLS AND MICRORNAS IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260810%WP4559%HOMO SAPIENS Interactions between immune cells and microRNAs in tumor microenvironment NFKB1 TRAF6 IL2RA IL2RB TLR8 TLR7 TLR4 TGFBR2 STAT3 CCL5 CTLA4 PDCD1 IL4 CCL2 SOCS1 TGFB1 IRAK4 CD80 NFKB2 IL2RG SARS COV 2 AND COVID 19 PATHWAY%WIKIPATHWAYS_20260810%WP4846%HOMO SAPIENS SARS CoV 2 and COVID 19 pathway ACE2 TMPRSS4 NRP1 SLC6A19 CTSL SCARB1 TLR7 TMPRSS2 FURIN ACAT1 NIPBL ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260810%WP5119%HOMO SAPIENS NIPBL role in DNA damage Cornelia de Lange syndrome H2AX MDC1 RNF8 NIPBL RNF168 ATM CBX3 ATR OMEGA 6 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260810%WP5424%HOMO SAPIENS Omega 6 fatty acids in senescence RB1 ELOVL2 HEL-S-22 PTGS1 GPX1 PTGIS FADS2 ALOX15 ALOX12 ALOX5 LTC4S FADS1 ALOX15B PRXL2B ALOX5AP PTGES MAPK11 PTGES3 DPEP2 ALOXE3 CYP4F8 NAT2 SLCO2A1 HEL-S-298 HPGD AKR1B1 PTGS2 EPHX2 SIRT1 DECR1 HEL-S-53e CDKN1A ELOVL5 TARGETED AGENTS IN TRIPLE NEGATIVE BREAST CANCER%WIKIPATHWAYS_20260810%WP5215%HOMO SAPIENS Targeted agents in triple negative breast cancer HRAS MAP2K1 MAP2K2 TSC2 TSC1 SOS1 PIK3R1 SOS2 MTOR NRAS EIF4EBP1 MAPK1 RAF1 PTEN MAPK3 AKT1S1 IRS1 MAPKAP1 DEPTOR RICTOR RPTOR ARAF AKT3 PARP2 INPP4B PARP1 RPS6KB1 MLST8 BRAF GRB2 1P36 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5345%HOMO SAPIENS 1p36 copy number variation syndrome IFIH1 AGRN PRKCZ DVL1 SKI MRPL20 PANK4 HES5 INTS11 INTS13 MMP23B PLCH2 INTS14 INTS10 GDE1 TMEM52 GNB1 NOC2L METTL14 SDF4 PLEKHN1 CCNL2 TNFRSF4 SMAD4 PEX12 ELAVL1 SAMD11 MUSK TNFRSF18 SSU72 PEX2 COMMD1 ATAD3A ATAD3C GLTPD1 ACAP3 ARF6 RER1 GRIK2 SCNN1D C1QTNF12 PEX5 MXRA8 VWA1 AURKAIP1 TNLG2B TNLG2A PERM1 KLHL17 MEPCE DKK3 LRP4 UBE2J2 PARD6B PHKG2 BTLA TNFRSF14 PUSL1 TAS1R3 HES4 OR4F5 OR4F3 CDK11A CFAP74 CD160 TRAF5 MIB2 B3GALT6 IFIT1 MCM2 PEX10 RNF223 MORN1 TMEM278 FNDC10 ANKRD65 INTS4 INTS9 SLC35E2B RBX1 C1orf159 SMAD2 TRIM25 TRAF2 VEGFA TGFB1 NADK ISG15 CALML6 VTN HEL-S-72p NEUROTRANSMITTER DISORDERS%WIKIPATHWAYS_20260810%WP4220%HOMO SAPIENS Neurotransmitter disorders MAOA DDC SLC18A2 DBH TPH2 SLC6A3 PNMT TPH1 TH TYPE III INTERFERON SIGNALING%WIKIPATHWAYS_20260810%WP2113%HOMO SAPIENS Type III interferon signaling IRF9 IFNLR1 IFNL2 STAT2 IFNL1 JAK1 TYK2 IFNL3 STAT1 IL10RB PEPTIDE GPCRS%WIKIPATHWAYS_20260810%WP24%HOMO SAPIENS Peptide GPCRs BRS3 CCKAR CCR7 CCR6 CCR4 CXCR4 AVPR1B AVPR1A TACR3 MC1R TACR1 SSTR2 OPRD1 NPY2R FPR2 IL8RB MC5R GHSR MC4R TSHR CCR8 LHCGR NPY1R FSHR NPY5R GRPR AVPR2 OPRM1 EDNRA SSTR3 SSTR4 SSTR5 GNRHR CCR5 CX3CR1 CCR3 BDKRB2 CCR2 NPY4R OXTR AGTR1 BDKRB1 MC3R CXCR1 AGTR2 EDNRB CXCR5 ATP8A1 CCKBR TACR2 OPRK1 CXCR6 FPRL2 TAC4 TRHR FPR1 C3AR1 MC2R GALR3 GALR2 GALR1 HCRTR2 C5AR1 HCRTR1 CCR10 NTSR2 CCR1 CXCR3 NTSR1 NMBR NON CLASSICAL ROLE OF VITAMIN D%WIKIPATHWAYS_20260810%WP5133%HOMO SAPIENS Non classical role of vitamin D ACE2 AGTR1 CYP27B1 REN AGTR2 CYP2R1 LAC PHE PATHWAY%WIKIPATHWAYS_20260810%WP5239%HOMO SAPIENS Lac Phe pathway ABCC5 CNDP2 ACRYLAMIDE BIOTRANSFORMATION AND EXPOSURE BIOMARKERS%WIKIPATHWAYS_20260810%WP4233%HOMO SAPIENS Acrylamide biotransformation and exposure biomarkers CYP2E1 SELECTIVE EXPRESSION OF CHEMOKINE RECEPTORS DURING T CELL POLARIZATION%WIKIPATHWAYS_20260810%WP4494%HOMO SAPIENS Selective expression of chemokine receptors during T cell polarization IL12A CCR3 CCR2 IL5 IL18R1 CSF2 CCR7 CXCR4 CCR4 CCL4 IL2 IL4 CCL3 CD40LG IFNG TGFB1 IFNGR1 IFNGR2 CCR1 CXCR3 IL12RB1 CCR5 IL12B ENDOCHONDRAL OSSIFICATION WITH SKELETAL DYSPLASIAS%WIKIPATHWAYS_20260810%WP4808%HOMO SAPIENS Endochondral ossification with skeletal dysplasias IGF1 CALM1 CAB39 MMP9 SOX6 STAT1 IHH ENPP1 PLAT GHR KIF3A GH1 RUNX2 PTH PTH1R THRA HMGCS1 PTHLH TIMP3 IGF1R FGF18 MGP opn FGFR1 SCIN SOX9 IGF2 SOX5 COL2A1 BMP7 CDKN1C BMP6 MEF2C ALPL RUNX3 FGF2 ADAMTS4 ADAMTS5 COL10A1 NKX3-2 BMPR1A DDR2 STAT5B CST5 VEGFA ACAN CHST11 FRZB GLI3 TGFB1 PTCH1 FGFR3 ERYTHROPOIESIS%WIKIPATHWAYS_20260810%WP5607%HOMO SAPIENS Erythropoiesis CD34 TFRC CD79A GATA2 IL3 HBZ GDF11 KITLG HBG2 TF HBG1 TNFSF6 KIT HBE1 EPOR EPO HBB IL3RA HBA2 HBD GATA1 PTPRC VITAMIN K METABOLISM AND ACTIVATION OF DEPENDENT PROTEINS%WIKIPATHWAYS_20260810%WP5186%HOMO SAPIENS Vitamin K metabolism and activation of dependent proteins NQO1 GGCX AIFM2 PROZ F10 PROC F7 F9 PROS1 VKORC1 F2 HYPOXIA MEDIATED EMT AND STEMNESS%WIKIPATHWAYS_20260810%WP2943%HOMO SAPIENS Hypoxia mediated EMT and stemness DICER1 REGULATION OF CYTOTOXIC T CELL RESPONSES BY MALAT1 MIR 15 16 CIRCUIT %WIKIPATHWAYS_20260810%WP5489%HOMO SAPIENS Regulation of cytotoxic T cell responses by Malat1 miR 15 16 circuit SPN IL2 CD27 BCL2 CD3G CD80 CD3E CD3D INTERACTOME OF POLYCOMB REPRESSIVE COMPLEX 2 PRC2 %WIKIPATHWAYS_20260810%WP2916%HOMO SAPIENS Interactome of polycomb repressive complex 2 PRC2 RBBP4 EED MORC3 ELL THRAP3 BCLAF1 STK38 TRIM35 RBBP7 JARID2 EZH1 SETX AEBP2 EZH2 SUZ12 FUMARATE HYDRATASE DEFICIENT PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260810%WP4241%HOMO SAPIENS Fumarate hydratase deficient papillary renal cell carcinoma SETD2 FH SFPQ RBX1 TFEB TGFA DVL2 EGLN3 EP300 CADM2 PRCC COL21A1 EGLN2 ELOC VEGFA CREBBP BIRC7 VHL TGFB1 EGLN1 HIF1A CDKN1A CTSK EICOSANOID METABOLISM VIA LIPOOXYGENASES LOX %WIKIPATHWAYS_20260810%WP4721%HOMO SAPIENS Eicosanoid metabolism via lipooxygenases LOX ACOX1 PTGR1 EHHADH FPR2 LTB4R HEL-S-298 HPGD TRPA1 ACOX3 ALOX15 TRPV1 ALOX12 ALOX5 CYP4F2 LTC4S CYP4A11 CYP4A22 ALOX15B NR1C1 CYP4F12 NR1C2 KPG_011 CAFFEINE IN NEURONS%WIKIPATHWAYS_20260810%WP5602%HOMO SAPIENS Caffeine in neurons ADRA1B ADRA1A ADRA1D ADORA2A INITIATION OF TRANSCRIPTION AND TRANSLATION ELONGATION AT THE HIV 1 LTR%WIKIPATHWAYS_20260810%WP3414%HOMO SAPIENS Initiation of transcription and translation elongation at the HIV 1 LTR NFKB1 CDK9 RELA NELFCD SUPT4H1 NELFA NELFE HEXIM1 SUPT5H NELFB NFKBIA SP1 HDAC5 EP300 PPP3CA HDAC2 HDAC3 PPP3CC HDAC1 CREBBP NFATC3 NFATC1 NFATC4 HDAC8 HDAC7 PPP3R1 PPP3R2 NFATC2 CHROMOSOMAL AND MICROSATELLITE INSTABILITY IN COLORECTAL CANCER %WIKIPATHWAYS_20260810%WP4216%HOMO SAPIENS Chromosomal and microsatellite instability in colorectal cancer TGFBR1 LEF1 POLK RALB APC DDB2 TGFBR2 BAK1 BIRC5 TCF7L2 RALA RAC3 APC2 BAD DCC EXOC2 TCF7L1 MSH3 BAX MSH2 CSNK1A1 PTGS2 CCND1 SMAD4 REL FOS CASP9 MAP2K1 NTN1 CSNK1A1L APPL1 MSH6 BBC3 MAPK9 CASP3 BCL2L11 MAPK1 RAF1 RAC1 PMAIP1 MAPK10 JUN MAPK3 GADD45B GADD45A GADD45G ARAF AKT3 SMAD2 GSK3B MYC MAPK8 ARHA BRAF AXIN1 TGFB1 AXIN2 BCL2 CYCS CDKN1A TBK1 WNT SIGNALING IN KIDNEY DISEASE%WIKIPATHWAYS_20260810%WP4150%HOMO SAPIENS Wnt signaling in kidney disease LRP5 LRP6 DVL1 DVL2 DVL3 WNT3 WNT4 MAPK9 FZD1 WNT10B WNT10A FZD3 FZD2 FZD7 MAPK10 INVS WNT2B FZD9 NPHP3 WNT7A FZD5 FZD4 FZD8 WNT1 WNT3A WNT7B MAPK8 ARHA WNT5B WNT9B WNT16 GLYCOLYSIS AND GLUCONEOGENESIS%WIKIPATHWAYS_20260810%WP534%HOMO SAPIENS Glycolysis and gluconeogenesis DLAT G6PC1 PDHA1 PCK1 GOT2 HEL-S-133P ENO1 HEL-S-68p HEL-S-281 PFKL PC ENO2 ENO3 DLD ALDOB MPC1 HK3 MPC2 HEL-S-49 PGAM1 PFKP PGAM2 FBP1 FBP2 HEL-S-162eP HEL-S-87p MDH2 SLC2A2 GCK PFKM PKLR SLC2A3 HEL-S-32 HEL-S-30 SLC2A4 HK2 NON GENOMIC ACTIONS OF 1 25 DIHYDROXYVITAMIN D3%WIKIPATHWAYS_20260810%WP4341%HOMO SAPIENS Non genomic actions of 1 25 dihydroxyvitamin D3 CAMK2G NFKB1 IFNAR2 TNFRSF1A PRKCZ HRAS TYK2 STAT1 MED1 NRAS NR1i1 STAT2 JAK1 IFNGR1 IFNGR2 IFI27L2 RSAD2 OAS2 DEFB4B NFKB2 CAMP SP1 SP3 CD40 CXCL8 CAMK2A IFNA2 RELB PLCG2 CD40LG PLCE1 NOD2 TLR8 TLR4 TNF MAPK9 IFNG RXRB MAPK1 CCL2 CYP27B1 MAPK12 MAPK13 CYP24A1 RXRA JUN MAPK11 MAPK3 PRKCA RXRG MAPK14 CAMK2D IKBKB PRKCB PLCB3 PLCB4 MAPK8 MAPK7 PLCB1 PRKCH PLCB2 PRKCE IL6 ISG15 PRKCQ LAMIN A PROCESSING PATHWAY%WIKIPATHWAYS_20260810%WP4299%HOMO SAPIENS Lamin A processing pathway LMNA ICMT ZMPSTE24 CELLULAR PROTEOSTASIS%WIKIPATHWAYS_20260810%WP4918%HOMO SAPIENS Cellular proteostasis PFDN2 PFDN4 PFDN5 PFDN6 VBP1 PFDN1 MIRNAS INVOLVED IN DNA DAMAGE RESPONSE%WIKIPATHWAYS_20260810%WP1545%HOMO SAPIENS miRNAs involved in DNA damage response H2AX RAD52 CDKN1B CDK6 CCNE1 CCND3 CREB1 MYC ATM CDKN1A CCND1 PPAR ALPHA PATHWAY%WIKIPATHWAYS_20260810%WP2878%HOMO SAPIENS PPAR alpha pathway UGT1A9 PLTP APOA5 CYP8B1 FABP1 CDK4 EHHADH MYC NR1H3 CYP7A1 CPT1A CCND1 APOC3 CYP4A11 ACADM NR1C1 RXRA KLK15 APOA2 SLC27A1 DBI CDC2 CPT2 DNA IR DAMAGE AND CELLULAR RESPONSE VIA ATR%WIKIPATHWAYS_20260810%WP4016%HOMO SAPIENS DNA IR damage and cellular response via ATR MDC1 TP53BP1 BRCA2 BCL6 HERC2 XPA FOXM1 UIMC1 MSH2 PLK1 SP1 DCLRE1A FEN1 CEP164 TOPBP1 RNF8 RMI1 TOP3A HUS1 EEF1E1 MCPH1 PPM1D RECQL4 CDC45 RBBP8 CLSPN POLN ABRAXAS1 CLK2 TDP1 BRCC3 PCNA SHFM1 BARD1 H2AX TRIM28 CHEK2 BRIP1 CHEK1 USP1 RPA1 NBN SMC1A FANCA FANCD2 PALB2 PRKDC ATRIP RFWD3 MCM2 MRE11A PML CDC2 SMARCAL1 RAD52 RAD50 XRCC5 RAD51 CDK2 MDM2 RAD17 PARP1 RAD1 ATM RECQL RAD9A ATR WRN IKBKG SMARCC2 UBE2D3 CANONICAL AND NON CANONICAL NOTCH SIGNALING%WIKIPATHWAYS_20260810%WP3845%HOMO SAPIENS Canonical and non canonical Notch signaling LEF1 DNER ADAM10 MAML2 HES1 MAML1 RRAS JAG2 NOTCH3 NOTCH4 PSEN2 MAML3 PSEN1 DLL3 DLK2 DLL4 MFAP1 MFAP2 NOTCH2 NOTCH1 CHUK RBPJ DEGRADATION PATHWAY OF SPHINGOLIPIDS INCLUDING DISEASES%WIKIPATHWAYS_20260810%WP4153%HOMO SAPIENS Degradation pathway of sphingolipids including diseases SCARB2 NEU4 NPC1 NPC2 LIPA HEL-S-111 NEU2 NEU3 HEXA GM2A PSAP GLB1 NEU1 GLA LNCRNA MEDIATED MECHANISMS OF THERAPEUTIC RESISTANCE%WIKIPATHWAYS_20260810%WP3672%HOMO SAPIENS lncRNA mediated mechanisms of therapeutic resistance BCL2L1 ABCB1 HIF1A CDKN1A KREBS CYCLE DISORDERS%WIKIPATHWAYS_20260810%WP4236%HOMO SAPIENS Krebs cycle disorders SUCLG2 PCK2 PDHX FH MPC1 DHTKD1 HEL-S-133P HEL-S-281 GPT SUCLA2 SUCLG1 CYTOPLASMIC RIBOSOMAL PROTEINS%WIKIPATHWAYS_20260810%WP477%HOMO SAPIENS Cytoplasmic ribosomal proteins RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPS20 RPS21 RPS24 RPS23 RPL23 RPS6KA6 RPS27A HEL-S-310 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPLP1 RPL34 RPLP0 RPL38 RPL13a RPL10A RPL8 RPL9 RPL6 RPL7 RPS15 RPS4X RPS14 RPL7A RPS17 RPS16 RPL18A RPS19 RPS18 RPL36 RPL35 RPLP2 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPL21 RPS7 RPS6KA2 RPS8 RPS6KA1 RPS5 RPL22 RPS3A RPSA RPS6 RPL37A RPL27 RPS6KB1 RPL26 RPS6KB2 RPL29 RPL28 RPL10 RPL12 MRPL19 FAU RPL11 RPL36A RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL41 RPL35A EIF5A REGULATION IN RESPONSE TO INHIBITION OF THE NUCLEAR EXPORT SYSTEM%WIKIPATHWAYS_20260810%WP3302%HOMO SAPIENS eIF5A regulation in response to inhibition of the nuclear export system EIF5A IGF2BP1 XPO4 NUCLEOTIDE EXCISION REPAIR IN XERODERMA PIGMENTOSUM %WIKIPATHWAYS_20260810%WP5114%HOMO SAPIENS Nucleotide excision repair in xeroderma pigmentosum POLD3 POLD4 CDK7 POLK RFC3 RFC4 SLX4 LIG1 POLD2 RFC2 DDB2 RPA1 DDB1 GPS1 RPA3 RFC1 SLX4IP CETN2 UVSSA XPA RAD18 POLE4 H2AC6 CCNH CHD1L POLE2 ERCC1 CUL4B GTF2H2C_2 POLE3 XPC H4C9 GTF2H2 GTF2H3 HMGN1 HIST1H4L GTF2H4 ERCC2 RBX1 MNAT1 PARP1 POLE XAB2 PCNA CUL4A H3F3B REGULATION OF SISTER CHROMATID SEPARATION AT THE METAPHASE ANAPHASE TRANSITION%WIKIPATHWAYS_20260810%WP4240%HOMO SAPIENS Regulation of sister chromatid separation at the metaphase anaphase transition CENPE STAG1 BUB1B ESPL1 MAD1L1 MAD2L1 SMC3 APC CDC20 PTTG1 RAD21 SMC1A TELOMERE END PACKAGING AND NEURODEVELOPMENTAL DISORDERS%WIKIPATHWAYS_20260810%WP5567%HOMO SAPIENS Telomere end packaging and neurodevelopmental disorders H2AX H2AC19 H2AB1 H3-4 H2AC14 H2BC26 H2BC12L H2BC21 HIST1H2AB H2BC9 H2AC6 TERF2 H2BC17 ACD TERF1 H2BC13 H2AJ TPP1 H2BC14 H2BC15 H2BC12 H2BC11 HIST1H2BE H4C9 HIST1H4L H2AZ1 H2AZ2 H2BC8 H2BC3 H2BC1 H2AC20 TERF2IP PGK1 PKM2 KHKC KHKA ACTING AS PROTEIN KINASES%WIKIPATHWAYS_20260810%WP5433%HOMO SAPIENS PGK1 PKM2 KHKC KHKA acting as protein kinases MYL2 SNAP23 H2AX HEL-S-68p KHK HEL-S-30 STAT3 AKT1S1 H3F3B HYPOTHESIZED PATHWAYS IN PATHOGENESIS OF CARDIOVASCULAR DISEASE%WIKIPATHWAYS_20260810%WP3668%HOMO SAPIENS Hypothesized pathways in pathogenesis of cardiovascular disease MAPK14 LTBP1 TGFBR1 AGTR1 NR2C2 SMAD2 FLNA TGFBR2 CTGF MAPK8 SHC1 MAPK1 SMAD4 FBN1 FBN2 ANGPT2 MAPK3 FBN3 POSTN RUNX2 LTBP2 TGFBR3 ENG EGFR TYROSINE KINASE INHIBITOR RESISTANCE%WIKIPATHWAYS_20260810%WP4806%HOMO SAPIENS EGFR tyrosine kinase inhibitor resistance IGF1 HRAS TGFA FGFR2 STAT3 SOS1 SOS2 NRAS BAD PTEN JAK1 BAX PDGFRA NRG2 SHC4 SHC2 SHC3 IGF1R RRAS EGFR CCND1 ERBB3 SHC1 ERBB2 PLCG2 PLCG1 RRAS2 BCL2L1 SRC MAP2K1 MAP2K2 PIK3CD PIK3R3 PIK3R2 PIK3R1 BCL2L11 KDR MTOR EIF4EBP1 MAPK1 RAF1 EIF4E AXL MAPK3 PDGFA PRKCA ARAF AKT3 IL6R GSK3B MYC RPS6 FGF2 HGF RPS6KB1 RPS6KB2 PRKCB NF1 FOXO3A VEGFA BRAF IL6 PDGFD BCL2 PDGFC EGF PDPK1 GRB2 FGFR3 NRG1 TGF 1 SMAD2 3 SIGNALLING IN DECIDUAL NK CELLS AT THE FETAL MATERNAL INTERFACE%WIKIPATHWAYS_20260810%WP5637%HOMO SAPIENS TGF 1 SMAD2 3 signalling in decidual NK cells at the fetal maternal interface KIR2DL4 FCGR3A TGFBR1 KLRK1 IL2RA CD9 SMAD2 CXCL8 TGFBR2 VEGFC IFNG SMAD4 TGFB1 ANGPT1 ITGAE CD14 ANGPT2 FOXP3 NCAM1 SMURF2 ITGA1 MODULATION OF PI3K AKT MTOR SIGNALING BY BIOACTIVE SPHINGOLIPIDS%WIKIPATHWAYS_20260810%WP5192%HOMO SAPIENS Modulation of PI3K Akt mTOR signaling by bioactive sphingolipids S1PR1 S1PR3 NFKB1 MTOR ASAH2 IGF1R CERK SPHK2 HIF1A LASS1 TSC1 TESSADORI BICKNELL VAN HAAFTEN SYNDROME 3 OVERVIEW PATHWAY%WIKIPATHWAYS_20260810%WP5575%HOMO SAPIENS Tessadori Bicknell van Haaften syndrome 3 overview pathway MED23 TAF8 MED27 TBP H4C9 TAF13 ENDOMETRIAL CANCER%WIKIPATHWAYS_20260810%WP4155%HOMO SAPIENS Endometrial cancer LEF1 POLK HRAS APC FGFR2 DDB2 BAK1 SOS1 CTNNA2 SOS2 TCF7L2 NRAS APC2 BAD TCF7L1 PTEN BAX EGFR CCND1 ERBB2 FOS FGFR1 CASP9 MAP2K1 MAP2K2 PIK3CD PIK3R3 PIK3R2 PIK3R1 CTNNA3 MAPK1 RAF1 MAPK3 GADD45B GADD45A GADD45G ARAF AKT3 GSK3B MYC FGF2 HEL-S-28 CTNNA1 FOXO3A BRAF AXIN1 AXIN2 EGF PDPK1 GRB2 FGFR3 CDKN1A NEURAL CREST CELL MIGRATION IN CANCER%WIKIPATHWAYS_20260810%WP4565%HOMO SAPIENS Neural crest cell migration in cancer MMP9 PIK3CD PIK3R3 PAK1 STAT3 F2RL2 TIAM1 TWIST1 PIK3R5 RAC1 PIK3R4 JUN ARF1 TRIO AKT3 CDH11 EPHB6 EPHB2 EPHB1 EPHB3 NTRK2 SORT1 KIDINS220 ARHA MMP2 PAK6 PAK4 NGFR FOS EPHB4 BDNF SOLUBLE ACE2 MEDIATED CELL ENTRY OF SARS COV 2%WIKIPATHWAYS_20260810%WP5076%HOMO SAPIENS Soluble ACE2 mediated cell entry of SARS CoV 2 ACE2 AGTR1 AVPR1B ADAM17 PTF1A RELATED REGULATORY PATHWAY%WIKIPATHWAYS_20260810%WP4147%HOMO SAPIENS PTF1A related regulatory pathway RBPJL KAT2B PROX1 HES1 NOTCH1 RBPJ FGF10 PDX1 NKX6-1 PTF1A VITAMIN B12 DISORDERS%WIKIPATHWAYS_20260810%WP4271%HOMO SAPIENS Vitamin B12 disorders MMAA MTRR TCN2 CBLIF TCN1 MMACHC MMADHC MTR CD320 CUBN AMN N GLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5153%HOMO SAPIENS N glycan biosynthesis RFT1 B4GALT2 MAN1A2 MAN1A1 ST6GAL1 ST6GAL2 ALG5 ALG10 DPAGT1 DDOST ALG8 MAN1B1 ALG9 ALG10B B4GALT1 FUT8 ALG6 GANAB TUSC3 MAN2A2 MAN2A1 SRD5A3 ALG2 MGAT5 ALG14 MGAT5B ALG13 MGAT3 ALG3 MGAT1 DOLK MGAT4C ALG12 MGAT4D ALG1 MGAT4A ALG11 DOLPP1 MGAT4B DPM1 STT3A GMPPB STT3B DPM2 DPM3 MGAT2 GCS1 MPDU1 RPN2 RPN1 DISORDERS OF MITOCHONDRIAL HOMEOSTATIS DYNAMICS PROTEIN IMPORT AND QUALITY CONTROL%WIKIPATHWAYS_20260810%WP5504%HOMO SAPIENS Disorders of mitochondrial homeostatis dynamics protein import and quality control MICOS13 OPA1 MFN1 MFN2 STAT2 HSPD1 AIFM1 CLPP LONP1 PARK2 PLEK ATAD3A MIPEP UFD1L UBXN1 CLPB OPA3 GDAP1L1 SACS PMPCB PMPCA UBXN6 MCL1 PAM16 OXA1L PPA2 TMEM126A VCP YME1L1 MICU1 HTRA2 SPG7 TRAK1 MFF TIMM50 PITRM1 MSTO1 C1QBP MARCHF5 DNAJC19 TIMM8A TIMMDC1 TXNRD2 AGK USP9X PYCR2 GFER TXN2 COQ5 COQ3 PINK1 NPLOC4 XPNPEP3 SFXN4 RTN4IP1 OPIOID RECEPTOR PATHWAYS%WIKIPATHWAYS_20260810%WP5093%HOMO SAPIENS Opioid receptor pathways HMOX1 ADCY1 ADCY8 NOS2 TLR4 TNF RELA SQSTM1 RGS4 RAC1 TUBB MBP OPRM1 RPLP2 ALDH9A1 DKFZp762B153 JUP ARC HDAC1 PRKCE CACNA1B GATA4 NEU2 HEL-S-72p BDNF GLYCINE METABOLISM%WIKIPATHWAYS_20260810%WP1495%HOMO SAPIENS Glycine metabolism SHMT1 HEL-S-51e PERTURBED THYROID HORMONE HOMEOSTASIS LEADING TO DEVELOPMENTAL NEUROTOXICITY%WIKIPATHWAYS_20260810%WP5517%HOMO SAPIENS Perturbed thyroid hormone homeostasis leading to developmental neurotoxicity SLC16A10 SLCO4A1 SLCO1A2 SLCO1C1 SLCO3A1 SLC16A2 SLC7A5 MITOPHAGY%WIKIPATHWAYS_20260810%WP5636%HOMO SAPIENS Mitophagy MUL1 PGAM5 RAB7B RHOT2 SAMM50 CSNK2A3 TBC1D17 CSNK2A2 TBC1D15 FIS1 OPA1 TFEB RAB7A HUWE1 CCZ1 TOMM7 MFN1 CALCOCO2 MFN2 SQSTM1 RAB5B RAB5C BCL2L13 SP1 RAB5A AMFR TOMM70 PHB2 PARK2 NBR1 OPTN BCL2L1 BECN2 SRC RHOT1 MAPK9 MAP1LC3A MAPK10 JUN VCP HIF1A AMBRA1 MTX1 SMURF1 TOMM40 MARCHF5 CSNK2A1 EIF2S1 USP15 MAPK8 TRAF2 ATF4 BNIP3L BNIP3 PINK1 FOXO3A ATG9A ULK1 NLRX1 CITED2 TOMM20 FUNDC1 SIAH1 ARIH1 TBK1 USP30 ATG9B ELECTRON TRANSPORT CHAIN OXPHOS SYSTEM IN MITOCHONDRIA%WIKIPATHWAYS_20260810%WP111%HOMO SAPIENS Electron transport chain OXPHOS system in mitochondria ATP5G1 HEL-S-271 ATP5IF1 COX2 COX7B SCO1 ND1 COX7C ND3 CYB ND2 UCP1 SLC25A14 UQCRFS1 ND5 COX6A1 ND4 ND6 NDUFS8 ATP8 UQCRC1 ATP6 NDUFS3 COX17 COXFA4 ATP5MC2 UQCRC2 ATP5J ATP5MC3 UQCRB ATP5H COX8A UQCR11 HEL-S-123m UQCR10 SLC25A27 COX5A COX11 UQCRH ATP5MG SLC25A4 ATP5MF ATP5ME DMAC2L SURF1 NDUFA9 ATP5PB COX6B1 ND4L ATP5F1D ATP5F1E UQCRQ ATP5PO COX7A1 NDUFA13 COX3 COX1 NDUFB10 SLC25A5 SLC25A6 NDUFA11 NDUFA12 NDUFA10 COX6A2 SDHC SDHD SDHA SDHB COX7A2L COX7A2 NDUFV3 NDUFV2 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA7 NDUFA6 NDUFA5 ZNF183 NDUFA3 NDUFA2 NDUFAB1 UCP3 UCP2 PARKIN UBIQUITIN PROTEASOMAL SYSTEM PATHWAY%WIKIPATHWAYS_20260810%WP2359%HOMO SAPIENS Parkin ubiquitin proteasomal system pathway PSMD7 PSMD4 PSMD2 PSMD3 PSMD1 GPR37 TUBA1C TUBA1B SNCA TUBB TUBB2A TUBA3E TUBB4B TUBB4A FBXW7 PSMC6 PSMC4 UBE2J1 PSMC1 TUBB8 TUBB6 UBE2L6 TUBB1 UBE2L3 TUBA4A RNF19A CASK SEPT5 TUBA4B PSMD12 PSMD13 HSPA14 CASP8 SIAH2 UBE2G1 HSPA2 UBE2G2 HSPA1A PARK2 TUBA1A TUBA2 TUBA8 TUBAL3 HEL-S-91n HSPA4 UBE2J2 HEL-S-89n SNCAIP CCNE1 STUB1 PSMD10 PSMD11 SIAH1 PSMD9 PSMD6 HEL-S-72p PSMD5 MELANOMA%WIKIPATHWAYS_20260810%WP4685%HOMO SAPIENS Melanoma POLK HRAS PDE5A CALM1 DDB2 E2F2 BAK1 PAK1 SOS1 SOS2 NRAS BAD PTEN BAX SHC2 CCND1 ERBB4 CDKN2A PREX2 WHR1 EXOC7 RHOB RB1 GRM3 MAP2K1 MAP2K2 PIK3CD PIK3R3 E2F3 PIK3R2 PIK3R1 KDR MAPK1 RAF1 RAC1 MAPK3 GADD45B GADD45A PTPN11 GADD45G HEL114 CDK6 CDK4 ARAF AKT3 MDM2 ARHA NF1 BRAF KIT CALML6 CALML3 CALML4 GRB2 CDKN1A LUPUS THERAPIES%WIKIPATHWAYS_20260810%WP5560%HOMO SAPIENS Lupus therapies C4A IL12A C1QC CD40 IL6R MS4A1 HEL-S-62p CD19 IL17A CD22 CD40LG IFNG C4B_2 IL23A C1QB IL6 C1QA IL17F IL17D TNLG7A IL17C IL17B CD80 IL12B THYMIC STROMAL LYMPHOPOIETIN TSLP SIGNALING%WIKIPATHWAYS_20260810%WP2203%HOMO SAPIENS Thymic stromal lymphopoietin TSLP signaling NFKB1 SRC MAP2K1 MAP2K2 STAT1 STAT3 RELA MAPK9 BTK EIF4EBP1 STAT4 MAPK1 FYN JAK1 MAPK3 PTPN11 NFKB2 LYN NFKBIA MAPK14 RPS6 MAPK8 RELB FES IL7R STAT5B LCK YES1 TSLP TEC CRLF2 GAB2 VITAMIN D RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2877%HOMO SAPIENS Vitamin D receptor pathway CYP2C9 NR1i1 NR1C2 BGLAP PTH DEFB4B CBS TNFRSF11B CAMP FGF23 EFNA5 DNER TIMP3 CEBPA ADRB2 CCND1 CST6 STEAP4 LPGAT1 FOXO1 CCNC GXYLT2 TRPV5 IRF8 CLDN2 CASP5 STS SALL4 KRT71 SLC34A2 MED9 S100A2 LCE1F LCE1D LCE2B CDC34 NINJ1 HNF1A S100A8 COL13A1 CLEC16A CRACR2A PTGER4 CRACR2B DND1 ADRA1B ALOX5 KRTAP4-1 SULT2A1 SLC37A2 KRTAP12-2 CYP2S1 SPRR1B CYP27B1 PNOC HSD17B2 ALPI CYP24A1 CLPTM1L RXRA JUNB MXD1 ALPG ZNF257 ORM1 ORM2 SULT1C2 DUSP10 DACT2 KRTAP5-1 CA9 ABCD1 IGFBP5 ID1 KRTAP5-4 KRT34 TNFSF11 BMP6 CEACAM1 KRT38 SATB1 HEL57 SEMA3B MYC ASAP2 IL1RL1 CST1 CLMN IRF4 CREG2 LRRC25 S100G KRTAP10-2 CTLA4 KRTAP10-4 CDX2 KRTAP10-7 MX2 KRTAP10-9 KRT13 CDKAL1 MYO9B TPM1 DEFB132 KRT16 PRKCQ CDKN1A G0S2 IL12A HLA-DRB1 LRP5 BCL6 TRPV6 CYP7A1 COLEC11 SLC8A1 HILPDA ATP2B1 CD14 S100A6 CYP1A1 PTHLH S100A9 CD9 CYP3A4 CD40 CDKN2D IGFBP1 KL KLF4 CDKN2B TNFAIP3 CDKN2C TREM1 CDKN2A LGALS9 opn SLC2A4 EPHB4 HLA-DQA2 HLA-DQA1 CASP14 CDKN1B SOSTDC1 TNLG2B SFRP1 S100A4 BTLA ID4 CCNE1 ITGAM KLK6 GADD45A KRTAP8-1 HIF1A CYP2B6 KNG1 THBD CD200 TRAK1 BDKRB1 ADGRE5 CDK2 ADAMTS5 TGFB1 ABCB1 NFATC2 TP53 NETWORK%WIKIPATHWAYS_20260810%WP1742%HOMO SAPIENS TP53 network MDM2 TP73 MYC ATM BBC3 CDKN2A TP63 SUMO1 TNFSF10 BOK PMAIP1 BAX BCL2 GADD45A OTX2 CDKN1A MTHFR DEFICIENCY%WIKIPATHWAYS_20260810%WP4288%HOMO SAPIENS MTHFR deficiency HEL-S-61p ASMT PEMT EHMT1 CHPT1 DNMT3B CHDH GRIN1 CASP3 MARS1 ALDH7A1 CYCS CASP9 CHKA SEROTONIN AND ANXIETY%WIKIPATHWAYS_20260810%WP3947%HOMO SAPIENS Serotonin and anxiety HTR1A ARC FMR1 CRH PRKCB PPP3CA TRPV1 HTR2A ADRA1A EEF2K POMC PLCD4 FOS PLEK EPITHELIAL TO MESENCHYMAL TRANSITION IN COLORECTAL CANCER%WIKIPATHWAYS_20260810%WP4239%HOMO SAPIENS Epithelial to mesenchymal transition in colorectal cancer TGFBR1 CLDN11 PAK1 COL4A6 TWIST2 NR2C2 MMP15 MMP2 SMAD4 CLDN6 RBPJ PALS1 CLDN2 CTDSP1 TUSC3 MAP2K3 MAP2K1 MAP2K2 PIK3CD PIK3R3 PKP2 NOTCH3 PIK3R2 PIK3R1 NOTCH4 WNT8A TWIST1 MAPK1 RAF1 DLL3 DLL4 FMNL2 MAP2K6 WNT2B NOTCH1 MAPK3 TJP1 RBBP4 ID1 SNAI1 WNT1 AKT3 WNT3A FZD10 WNT7B LATS2 WNT5B WNT9B SPARC GRB2 WNT16 HEL-S-79 CDKL2 CLDN3 CLDN9 CLDN7 PKP1 EIF5A2 LRP5 NRP2 PKD1 CLDN22 HRAS CLDN20 LRP6 CLDN24 CLDN23 MMP9 CLDN10 TGFBR2 CLDN15 CLDN14 WNT3 CLDN19 WNT4 STRAP FZD1 CLDN18 SOS1 WNT10B WNT9A CLDN17 SOS2 FOXM1 CLDN16 WNT8B WNT10A NUBPL FZD3 CRB3 FZD2 FZD7 FZD9 WNT7A MEF2D EED TMPRSS4 CLDN1 COL4A2 COL4A1 CDH2 GIG8 CLDN5 JAG2 ZEB2 SHC1 GDF15 CLDN4 NOTCH2 SNAI2 FOXC2 FOXQ1 TRAF6 EZH2 MAPK12 MAPK13 SUZ12 MAPK11 HIF1A FZD5 JUP MAPK14 FZD4 PROX1 FZD8 SMAD2 GSK3B MAPK8 COL4A4 COL4A3 COL4A5 MAP2K4 TGFB1 VTN AMINO ACID METABOLISM%WIKIPATHWAYS_20260810%WP3925%HOMO SAPIENS Amino acid metabolism HEL-S-61p PDHX PDK4 PDHA1 SRM PCK1 GOT2 HEL-S-133P P4HA2 CS HEL-S-64p SMS GLUD1 ALDH18A1 DLD TDO2 ACADM ARG2 LARS2 HEL-75 PPM1L RARS1 HDC MARS2 BCAT1 HMGCL VARS1 G6PC2 EPRS1 OGDH ACO2 CBS IARS FARSB DDC FH CTH MDH2 GCLM ADH5 ACSS1 PIG59 ADH1C ALDH7A1 HEL-S-53e HAL GPT2 FTCD SUCLG1 HEL-S-26 HEL-S-4 ARG1 ASNS ASS1 PC SDHA MCCC1 OTC PNMT GLS TH MAOA TPO DBH ACLY EHHADH TPH1 CAD HEL-S-32 ADH7 HEL-S-30 HEAD AND NECK SQUAMOUS CELL CARCINOMA%WIKIPATHWAYS_20260810%WP4674%HOMO SAPIENS Head and neck squamous cell carcinoma NFKB1 FAT1 HRAS MAML1 TGFBR2 NUMB NRAS PIK3R5 PTEN STK11 FADD NFKB2 CSMD3 LTBR FKBP1A IGF1R PRKAA2 EGFR CCND1 CDKN2A CASP8 TP63 ERBB2 MLST8 SMAD4 REL SESN2 BIRC2 NOTCH2 FGFR1 TRAF3 RB1 SESN1 PRKAA1 RHEB TSC2 TSC1 RELA PIK3R2 PIK3R1 MTOR EIF4EBP1 EIF4E NOTCH1 NFE2L2 KEAP1 MAPKAP1 RICTOR RPTOR CDK6 CDK4 AKT3 TERT RPS6 RPS6KB2 AJUBA VEGFA DDIT4 IRF6 PDPK1 FGFR3 CDKN1A PERTURBATIONS TO HOST CELL AUTOPHAGY INDUCED BY SARS COV 2 PROTEINS%WIKIPATHWAYS_20260810%WP4936%HOMO SAPIENS Perturbations to host cell autophagy induced by SARS CoV 2 proteins APOB VPS16 OPTN RAB7A RHEB CALCOCO2 ATG2B SQSTM1 MTOR VPS41 TMEM59 RB1CC1 LAMP2 ATG3 GABARAPL2 AKT1S1 DKFZp762B153 DEPTOR PPP1R9A RPTOR LARP1 VAMP8 LAMTOR1 PRKAA2 EIF4B ATG16L1 VPS39 RPS6 RPS6KB1 DKFZp686F0183 MLST8 ATG12 ATG9A ULK1 VPS18 VPS33A NBR1 HEL-S-30 COMPLEMENT SYSTEM%WIKIPATHWAYS_20260810%WP2806%HOMO SAPIENS Complement system TXN FCN1 HEL-S-62p FGA ELANE F10 DKFZp686L0365 F11 PLG GNA15 F13A1 IBSP HEL-S-78p ITGB3 CSNK1A1 DCN LAMC1 FCGR3A THBS1 FCN2 C4BPA CFD CD40 VSIG4 CRP CD93 CFB HEL-S-92n FCER2 ADM FKBP2 CD59 SELL CFHR2 CFHR4 CLEC4M ALB ICAM2 MBL2 opn HEL-S-99n SFTPA2 CD19 SELPLG RPS19 SELP ITGA2B C1S CFP CPN1 C8A C6 PRKCA GNAI3 C7 C9 MASP2 C4A MASP1 CD55 SELE ITGA2 SERPING1 C1QBP KLKB1 PRNP LAMB1 CR1 PROS1 PLAUR PTX3 FPR1 SFTPA1 C3AR1 CR2 CD46 CFH WAS CFI C5AR2 C5AR1 LAMA5 VTN TRANSCRIPTION CO FACTORS SKI AND SKIL PROTEIN PARTNERS%WIKIPATHWAYS_20260810%WP4533%HOMO SAPIENS Transcription co factors SKI and SKIL protein partners HDAC3 MERTK NF1 HDAC1 SKI TEAD2 TEAD3 TEAD4 LATS1 SKIL SIN3A LATS2 PENTOSE PHOSPHATE PATHWAY IN SENESCENT CELLS%WIKIPATHWAYS_20260810%WP5043%HOMO SAPIENS Pentose phosphate pathway in senescent cells HEL-S-304 PRPS1L1 DERA RPIA RPE LINOLEIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260810%WP5137%HOMO SAPIENS Linoleic acid oxylipin metabolism ALOX5 EPHX2 ALOX15 8P23 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5346%HOMO SAPIENS 8p23 1 copy number variation syndrome BMP1 MSRA HEL-S-130P CLDN23 BLK MTMR8 TERF1 MTMR9 MTMR6 NKX6-1 HSPD1 FDFT1 SGPL1 PINX1 HEPACAM2 C8orf7 SOX7 GATA4 CGAS SLC35G5 PRSS55 NEIL2 PPP1R3B SLBP SLC2A4 CSTA PRSS51 ERI1 S100A10 MCRS1 DEFB136 TBX5 C8orf74 DEFB135 TNKS DEFB134 RP1L1 MFHAS1 FAM167A TLR4 FCGR2A FCGR2B PDX1 MAPK1 RAF1 MAPK3 TERT NUMA1 AXIN1 LEUKOCYTE INTRINSIC HIPPO PATHWAY FUNCTIONS%WIKIPATHWAYS_20260810%WP4542%HOMO SAPIENS Leukocyte intrinsic Hippo pathway functions YWHAQ FYB1 FOXO6 STK38L CCR7 KNSTRN CD19 RAB13 FERMT3 WWTR1 RAC1 MAPK14 YAP1 FOXO4 TEAD2 TEAD3 TEAD4 LATS1 MOB1A RAP1A LATS2 ARHA FOXO3A LPL FOXO1 FOXP3 EVOLOCUMAB MECHANISM TO REDUCE LDL CHOLESTEROL%WIKIPATHWAYS_20260810%WP3408%HOMO SAPIENS Evolocumab mechanism to reduce LDL cholesterol LDLR PCSK9 AMINO ACID CONJUGATION OF BENZOIC ACID%WIKIPATHWAYS_20260810%WP521%HOMO SAPIENS Amino acid conjugation of benzoic acid GATF-C GLYATL2 ACSS2 IL1 AND MEGAKARYOCYTES IN OBESITY%WIKIPATHWAYS_20260810%WP2865%HOMO SAPIENS IL1 and megakaryocytes in obesity IL1B CCR3 NFKB1 NLRP3 S100A9 MYD88 IL1R1 MMP9 IL18 F2 HEL-S-134P PLA2G7 IFNG FCER1A CCL2 IRAK1 HBEGF F2R TLR1 TIMP1 DNAJB1 PRKACA FUSION IN FIBROLAMELLAR LIVER CANCER%WIKIPATHWAYS_20260810%WP5514%HOMO SAPIENS DNAJB1 PRKACA fusion in fibrolamellar liver cancer CRTC2 GNAS SIK3 SIK2 DNAJB1 CREB1 HDAC7 HDAC5 SIK1 ARACHIDONATE EPOXYGENASE EPOXIDE HYDROLASE%WIKIPATHWAYS_20260810%WP678%HOMO SAPIENS Arachidonate epoxygenase epoxide hydrolase EPHX2 HEL-S-22 CYP2C9 CYP2J2 COX8A COX5A PROSTAGLANDIN SYNTHESIS AND REGULATION%WIKIPATHWAYS_20260810%WP98%HOMO SAPIENS Prostaglandin synthesis and regulation S100A10 SOX9 TBXA2R PTGS1 PTGIS PTGER4 PTGER1 PTGER2 PTGER3 PTGIR PTGES ANXA6 PTGFRN EDNRA ANXA3 ANXA4 SCGB1A1 HEL-S-7 AKR1C1 S100A6 EDN1 AKR1C2 EDNRB PRL ANXA1 PTGDR HPGD AKR1B1 PTGS2 PPARG PTGFR PPARGC1A ANXA2 HSD11B1 HSD11B2 PPARGC1B CYP11A1 GLUCOSE METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260810%WP5211%HOMO SAPIENS Glucose metabolism in triple negative breast cancer cells HEL-S-133P HEL-S-30 PFKP PPM2C LUPUS PATHOGENESIS%WIKIPATHWAYS_20260810%WP5559%HOMO SAPIENS Lupus pathogenesis BCR TLR9 TLR7 CD40 TLR4 IFNA2 IL17A PDCD1 CD40LG IL6 TNLG7A ICOS CD80 TNFRSF13C DRAVET SYNDROME%WIKIPATHWAYS_20260810%WP5200%HOMO SAPIENS Dravet syndrome NFKB1 CALM1 TNF SCN8A MTOR SNTA1 MAPK11 PRKCA MAPKAP1 PRR5 KCNA2 RICTOR SCN4B PCDH19 SCN3A SCN1B SCN2B STXBP1 CHD2 CAMK2A SCN1A MLST8 FGF13 HCN1 SCN2A SCN3B WNT SIGNALING NETPATH%WIKIPATHWAYS_20260810%WP363%HOMO SAPIENS Wnt signaling NetPath LEF1 LRP5 LRP6 ROR2 APC DVL1 CTBP1 DVL2 DVL3 TSC2 TSC1 NLK MAPK9 TCF7L2 MTOR MAPK1 DKFZp686L0365 RAC1 STM7 GSK3A PRKCA CSNK1A1 BCL9 CDK6 GCKR RYK TCF4 CSNK1G1 GSK3B ROR1 hCG_2014051 PRKCB FRAT1 MAPK8 CCND1 TCF3 ARHA MAP3K7 PPARG CSNK1D AXIN1 PI4K2A SOX1 NFATC2 GENES TARGETED BY MIRNAS IN ADIPOCYTES%WIKIPATHWAYS_20260810%WP1992%HOMO SAPIENS Genes targeted by miRNAs in adipocytes GJA1 IGF1 KCNJ2 HCN4 KCNE1 TMSB4X HAND2 HCN2 ERG LIVER X RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2874%HOMO SAPIENS Liver X receptor pathway CYP3A4 RXRA SCD NR1H3 CYP7A1 ABCG8 CYP2B6 ABCG5 FASN TYPE I COLLAGEN SYNTHESIS IN THE CONTEXT OF OSTEOGENESIS IMPERFECTA%WIKIPATHWAYS_20260810%WP4786%HOMO SAPIENS Type I collagen synthesis in the context of osteogenesis imperfecta PLOD1 LRP5 ADAMTS2 BMP1 P4HA1 LRP6 P4HA2 PLOD2 FZD1 TNFRSF11B COL1A1 TNFSF11 COL1A2 WNT1 TNFRSF11A MIA3 TMEM38B COLGALT1 IFITM5 MBTPS1 CRTAP P3H2 P3H1 MBTPS2 SP7 PPIB HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES APOPTOSIS%WIKIPATHWAYS_20260810%WP4864%HOMO SAPIENS Host pathogen interaction of human coronaviruses apoptosis MAPK14 BCL2L1 APAF1 TNF BBC3 CASP3 CASP8 BCL2L11 BAD MAPK12 MAPK13 BAX MAPK11 TNFSF6 MCL1 BCL2 FADD CASP9 16P11 2 DISTAL DELETION SYNDROME%WIKIPATHWAYS_20260810%WP4950%HOMO SAPIENS 16p11 2 distal deletion syndrome LAT HEL-S-62p CD19 VAV2 KDR IL4 IFITM1 TRAF1 MPL RAB5A TRAF2 ATP2A1 CR2 CD81 CD82 PLN SLN NFATC2IP SH2B1 INSR TUFM ATXN2L RABEP2 PRMT1 SPNS1 GRB2 RAB4A SDCCAG8 NFATC2 HSPB3 IN CHARCOT MARIE TOOTH DISEASE%WIKIPATHWAYS_20260810%WP5524%HOMO SAPIENS HSPB3 in Charcot Marie Tooth disease HP1BP3 HSPB2 HSPB3 MEF2C H2AZ1 LBR MYOG NOTCH3 LMNA ACTA1 DES DMPK MYOD1 HEL25 FLT3 P GLN640SERFSTER8 SIGNALING%WIKIPATHWAYS_20260810%WP5431%HOMO SAPIENS FLT3 p Gln640SerfsTer8 signaling FLT3 STAT3 CCR6 CCR5 MAPK SIGNALING%WIKIPATHWAYS_20260810%WP382%HOMO SAPIENS MAPK signaling NFKB1 TGFBR1 TNFRSF1A IL1R1 MAP3K14 FGFR2 CDC42 PAK1 DKFZp686L0365 FGF3 FGF6 FGF9 FGF20 FGF22 FGF17 FGF16 FGF14 EGFR FGF18 PRKACG DUSP2 FGF13 HSPA2 FGF12 CACNA1C HSPA1A CACNA1F CACNA1S STK4 PPP5C CACNA2D1 CACNA2D3 CACNA2D2 MAP3K12 CACNA2D4 CACNB1 CACNB3 CACNB4 CACNG6 CACNG7 DDIT3 CACNG1 CACNG3 CACNG4 CACNG5 PDGFA FGF4 DUSP10 NTF4 RPS6KA4 FGF8 RPS6KA5 MEF2C PPP3CC FGF10 BDNF MAP3K8 MAP3K6 CD14 NGF MAP3K13 NFKB2 HEL-S-31 RASGRF1 MAPKAPK5 MAP4K2 RASGRP4 MAP4K3 RASGRP3 NTRK2 RRAS RASGRF2 MAPKAPK2 PLA2G4F PLA2G4D PLA2G4E PLA2G4C ECSIT RRAS2 FOS IL1B TRAF6 JUND RELA MAPK9 MAPK12 MAPK13 MAPK10 MAP3K7IP1 MAPK11 GADD45A CRK NTRK1 PPP3R1 FGFR4 PPP3R2 FGFR3 MAPK8IP2 MAPK8IP3 MAPK8IP1 DUSP8 DUSP9 DUSP7 RAPGEF2 NTF3 TAOK3 TAOK2 CACNA1H CACNA1G CACNA1I DUSP16 PPM1B pk RAC3 FGF23 FGF21 RELB RAP1A MAP3K2 LAMTOR3 MAP2K3 MAP2K1 TAOK1 MAP2K2 MAPK1 FGF7 RAF1 CDC25B MAP3K11 MAP2K6 MAP3K5 MAPK3 FGF19 SMIM40 ARAF AKT3 LRRK2 MYC ATF4 NFATC3 NFATC1 BRAF TNFSF6 GRB2 HEL-S-72p HRAS TGFBR2 IL1R2 SOS1 SOS2 NRAS FLNA CRKL FLNB DUSP4 HEL-S-102 ATF2 MAX RASA2 FGFR1 MAPKAPK3 CACNG8 TNF CACNG2 PLA2G4B NLK CASP3 RAC1 JUN PRKCA DUSP3 MAPK14 IL1A FGF2 IKBKB PPP3CA MAPK8 MAPK7 TRAF2 IKBKG NF1 MAP3K7 PTPN5 MAP2K5 MAP4K1 MAP2K4 CACNA1B CACNA1A TGFB1 MAP3K1 CHUK EGF GNG12 15Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4940%HOMO SAPIENS 15q11 2 copy number variation syndrome CYFIP1 FMR1 NIPA1 TUBGCP5 TUBGCP6 NIPA2 TUBGCP4 OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS%WIKIPATHWAYS_20260810%WP5095%HOMO SAPIENS Overview of proinflammatory and profibrotic mediators NFKB1 CCL11 OSM IL19 CXCL17 IL4 CXCL14 CXCL16 IL36A IL36B IL36RN CCL14 TNFSF13 IL36G CCL13 PPBP CCL3L3 IFNW1 IL1F10 IL9 CXCL6 IL20 IL26 IL24 CCL8 IL27 CCL7 PF4V1 XCL2 XCL1 CCL1 CCL17 CCL25 CCL18 CCL24 CCL23 IL31 CSF2 CCL22 CCL16 IL37 CX3CL1 CCL27 CXCL2 CCL15 CCL26 MMP3 IL2 TNLG7A TSLP AREG IL18 LIF CNTF CSF1 EPO IL1RN CTF1 IL11 VEGFA IL23A IL3 IL6 LTA CCL19 IL12B CCL28 IL12A IFNA13 IFNA14 IFNA16 IFNA17 MMP9 IFNA10 IL13 EBI3 IL7 IFNA21 IL15 CSF3 IL33 CXCL11 IFNA5 CXCL1 IFNA4 IFNA7 CXCL5 CXCL9 CXCL8 IFNA6 IFNA1 IFNA2 IFNA8 CCL20 IL17F IL17D IL17C IL17B opn IL1B IL5 CXCL12 TNF CCL5 CCL4 CCL3 IFNG CCL2 IFNB1 IL10 PF4 IL22 CXCL13 IL1A IL-21 IFNL2 IFNL1 IFNL3 CCL21 CXCL3 IL17A IFNK TGFB1 CCL4L2 COCAINE METABOLISM%WIKIPATHWAYS_20260810%WP2826%HOMO SAPIENS Cocaine metabolism CES2 CES1 CYP3A4 BCHE DNA REPLICATION%WIKIPATHWAYS_20260810%WP466%HOMO SAPIENS DNA replication PRIM1 POLD3 POLD4 RFC3 RFC4 POLD2 RFC2 RPA1 RPA3 RFC1 POLA1 POLA2 POLE2 MCM2 GMNN UBC CDK2 POLE MCM7 CDC45 ORC1L MCM10 ORC6 ORC3 ORC2 CDT1 CDC6 PCNA DBF4 RPA4 MCM3 MCM5 MCM6 PRIM2 PHOSPHATIDYL INOSITOL PHOSPHATE PATHWAY%WIKIPATHWAYS_20260810%WP5411%HOMO SAPIENS Phosphatidyl inositol phosphate pathway FIG4 PIK3CD MTMR1 INPP5D MTMR2 INPP4A MTMR8 PTEN PIK3C2G STM7 MTMR6 MTM1 PIK3C2B PIP4P2 PIP4P1 PIP4K2A PIP4K2B PIP5K1C SACM1L OCRL INPP4B INPP5E PIKFYVE PLCB3 PLCB4 PIP5K1A IPMK PLCB1 PLCG2 PLCB2 PLCE1 PLCG1 PLCD3 PI4K2A PLCD4 PI4K2B TPTE2 PI4KB TAR SYNDROME%WIKIPATHWAYS_20260810%WP5362%HOMO SAPIENS TAR syndrome HLA-B NFKB1 HLA-C HLA-A HLA-F TXN HLA-G HLA-E STAT3 CXCR4 RBCK1 POLR3GL POLR3C POLR3F POLR3G ITGB1 BCL2L13 LAMTOR1 CCAR2 SLC34A3 EGFR HDAC2 ANKRD35 EIF4A3 GPR89B SLK CFTR SUMO2 MAGOH NUDT17 HEL-S-76p SLC22A4 PEX11B ZFHX3 CLCN3 FURIN PEX19 NHERF1 FARP2 UBE2I PYM1 PDZK1IP1 MITD1 TNFRSF14 IFNG FLT3 CD160 AKAP10 CD3D HAMP SIRT1 DDIT4 LCK SOMATIC SEX DETERMINATION%WIKIPATHWAYS_20260810%WP4814%HOMO SAPIENS Somatic sex determination SOX9 WT1 NR5A1 SOX8 AMH WNT4 DMRT1 DHH FOXL2 SRY GATA4 FGF9 RSPO1 PLEURAL MESOTHELIOMA%WIKIPATHWAYS_20260810%WP5087%HOMO SAPIENS Pleural mesothelioma IGF1 NFKB1 CSNK2A3 CDK7 CSNK2A2 DKK2 DKK4 FGFR2 SFRP4 VEGFB CSNK2B STAT1 ULK2 PAK1 VEGFC VEGFD CTNNA2 ACTA2 FGF3 TCF7L1 JAK1 FGF6 FGF9 BAP1 COL4A6 CSNK1A1 EFNA5 EFNA4 SP1 FGF20 FGF22 FGF17 EFNA1 ROR1 EFNA3 FGF14 EGFR EFNA2 YY1 CCND1 FGF18 FGF13 FGF12 CREB1 FOXO1 ANGPT4 EIF4G1 MAP3K10 CSNK1A1L BBC3 CTNNA3 DDIT3 CSF1R RB1CC1 WNT2B ATF3 SOST CSF1 PDGFA INS FGF4 NTF4 DEPTOR RPTOR FGF8 CTHRC1 RPS6KA5 RPS6KA1 WNT1 LAMA1 LAMA3 LAMC2 EIF4B CSNK2A1 LAMB3 RPS6 WNT3A LAMB1 HGF RPS6KB1 WNT7B RPS6KB2 FLT3LG DKK1 VEGFA IL6 KITLG KIT FGF10 SPARC BDNF TGFA APC BAK1 FOXM1 MAP3K6 PTEN HMGB1 RASSF1 NGF HEL-S-31 CIT MEF2D HMGN1 MAP4K2 MINK1 MAP4K3 NTRK2 MAPKAPK2 MLST8 LGALS9 IL1B CXCL12 SOX17 CCND3 UHRF1 CCND2 STK38L SFRP1 MAPK9 CCL5 CCL4 CCNE1 EZH2 FLT3 WIF1 FLT4 MAPK10 SUZ12 CDH9 AMOT CDH4 SETD2 HEL-S-104 ITGA4 ITGA2 RYK CDK4 CDH10 CDK2 CDH11 MDM2 CDH12 ITGA6 ATM CDH15 CDH16 AJUBA CDH17 VGLL4 MMP14 CDH19 EPHA2 CTNNA1 CDH24 PAK6 PAK4 NTRK1 NGFR ANGPT1 INSR ANGPT2 LIN28B FGFR4 FGFR3 SLC7A5 NTF3 PIGF RING1 DKFZp781B1423 PDGFRA CDH18 AKT1S1 ITGB3 ITGAV FGF23 PRKAA2 CSF2 ACTG2 FGF21 MMP2 MMP3 BTRC AREG IGF2 NLRP3 MAP3K2 MAP2K3 MAP2K1 RHEB PRKAA1 MAP2K2 PIK3CD TSC2 TSC1 PRKAB2 MTOR RASSF2 PRKAG1 EIF4EBP1 RASSF3 PRKAG2 MAPK1 RASSF4 FGF7 RAF1 RASSF6 CER1 MAP3K11 PRKAB1 HCFC1 MAP2K6 BTC MAP3K5 MCL1 SFRP5 PRKAG3 MAPK3 PHC1 HBEGF SETDB1 RASSF7 SETD5 LIMD1 BMI1 RBBP4 PRSS23 KREMEN1 FGF19 KIF23 YAP1 IL34 NOTUM WWC1 AKT3 TNIK TEAD2 DSC3 TERT TEAD3 KMT2C MYC TEAD4 PORCN BAG2 LATS1 FZD10 MOB1A CHD8 hCG_2014051 PRB1 FRAT1 PLCB4 MDK PRB2 LATS2 ACTG1 WDR5 SENP2 CXXC4 RNF2 MOBKL1A WNT5B ASXL1 AXIN1 BCL2 CYCS GRB2 WNT16 ACTA1 CDKN1A TNNT1 CD44 CTBP2 LEF1 LRP5 HEL-S-1 HRAS LRP6 MMP9 DVL1 DVL2 DVL3 WNT3 WNT4 FZD1 SOS1 WNT10B TCF7L2 WNT10A FZD3 FZD2 MAD1L1 IDO1 MAD2L1 FZD7 BAX FZD9 CD47 WNT7A FOSL1 LAMB2 LAMA4 ITGB1 ITGA1 CSF3 FLT1 LAMC1 EED CXCL1 COL4A2 CXCL5 IGF1R COL4A1 CDH2 ATF2 CDKN2A SHC1 MAX SLC3A2 PPARGC1A FGFR1 BARD1 CDH8 PS1TP5BP1 CDH6 SRC ROR2 ITGB4 CTBP1 CTGF WWTR1 KDR CCL2 GABPA IL10 JUN HIF1A FZD5 MAPK14 SELE TTI1 AGER FZD8 GSK3B FGF2 NF2 MAPK8 MAPK7 OGT TRAF2 COL4A4 COL4A3 MAP2K5 ULK1 MAP4K1 COL4A5 MAP2K4 TGFB1 MAP3K1 PDGFD PDGFC LAMA5 EGF FRAT2 TARGETED THERAPY IN BREAST CANCER%WIKIPATHWAYS_20260810%WP5496%HOMO SAPIENS Targeted therapy in breast cancer HRAS AKT3 PIK3CD PIK3R3 EGFR PIK3R2 ERBB3 PIK3R1 ERBB4 ERBB2 NRAS MAPK1 PIK3R5 RAF1 PIK3R4 PIK3C2G MAPK3 PIK3C2B NRF2 ARE REGULATION%WIKIPATHWAYS_20260810%WP4357%HOMO SAPIENS NRF2 ARE regulation NQO1 SLC7A11 HMOX1 PGAM5 GCLC GCLM RBX1 SRC CEBPB GSK3B EPHB2 MAPK8 MAF FYN INSR YES1 NFE2L2 KEAP1 PRKCA AIMP2 MIRNA REGULATION OF PROSTATE CANCER SIGNALING%WIKIPATHWAYS_20260810%WP3981%HOMO SAPIENS miRNA regulation of prostate cancer signaling NFKB1 CDKN1B AKT3 GSK3B MAP2K1 MDM2 MAP2K2 CCND1 SOS1 IKBKG MTOR CREBBP MAPK1 BAD RAF1 KLK3 BCL2 PDGFA GRB2 FOXO1 CDKN1A CASP9 NFKBIA OVERVIEW OF NANOPARTICLE EFFECTS%WIKIPATHWAYS_20260810%WP3287%HOMO SAPIENS Overview of nanoparticle effects HMOX1 PTGS1 CCND3 CRP LAMA3 COL4A1 AKT3 CXCL8 PIK3CD TNF PTGS2 IL6 BAX NFRKB BCL2 NEPHROTOXCICITY ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260810%WP5229%HOMO SAPIENS Nephrotoxcicity adverse outcome pathway SLC31A1 ONE CARBON METABOLISM%WIKIPATHWAYS_20260810%WP241%HOMO SAPIENS One carbon metabolism MTRR HEL-S-61p AHCYL2 DNMT3B CHDH TCN2 AMT MTHFD1 MTR MTHFD2 TYMS MTFMT HEL-S-70p SHMT1 GLRX MTHFS HEL-S-51e FOLH1 MTHFD1L MAT1A FTCD DHFR CILIOPATHIES%WIKIPATHWAYS_20260810%WP4803%HOMO SAPIENS Ciliopathies BBS4 CEP290 TRAF3IP1 INVS NPHP3 ZNF423 CEP164 C2CD3 CEP19 DYNC2H1 DYNC2I2 IFT172 IFT140 IFT52 TCTN3 DYNLT2B IFT80 TCTN2 TMEM107 TCTN1 WDR35 DYNC2LI1 BBS9 BBS7 IFT43 IFT81 IFT27 IFT57 CC2D2A BBS5 RPGRIP1L LZTFL1 BBS10 EVC BBS12 TMEM216 CCDC41 WDPCP CEP104 ARL6 ARL3 ARL13B TMEM67 INPP5E SMO PIBF1 EVC2 BBS2 BBS1 SCLT1 CPLANE1 TMEM231 TTC8 TMEM17 ODAD1 B9D1 ODAD3 ODAD4 CLUAP1 CCDC28B MCIDAS TBC1D32 NEK1 NEK2 DNAAF3 CFAP418 PKD1 DNAAF2 CENPF DNAJB13 DNAAF6 CFAP410 FAM161A TMEM138 CCNQ CCNO INTU HEL-S-296 AK7 PKHD1 NPHP1 CEP78 PLK4 NEK8 NEK9 KIAA0753 DCDC2 PIK3R4 DNAAF19 ARL2BP TMEM237 OFD1 UNC119 DRC1 DNAL1 DNAAF11 FLCN SUFU HYDIN IQCB1 CCDC39 DNAI2 CFAP52 CNGA1 KIF7 RAB23 TOPORS OCRL RP1 RP2 NME9 CNGB1 EFHC1 WDR51B ZMYND10 KIZ CFAP53 CCDC40 KATNIP ANKS3 DNAH6 PKD1L1 RSPH9 TULP1 CFAP298 POC1A RAB28 DNAI1 TUB DYX1C1 PCARE RSPH3 RPGRIP1 TTLL5 RSPH1 ALMS1 SPAG1 HYLS1 CEP41 ADCY6 RP1L1 B9D2 ATXN10 TRIM32 BBIP1 ZIC2 CRX MKS1 USP9X GPR161 XPNPEP3 NME7 GLI3 PDE6D AHI-1 SDCCAG8 THYROID STIMULATING HORMONE TSH SIGNALING%WIKIPATHWAYS_20260810%WP2032%HOMO SAPIENS Thyroid stimulating hormone TSH signaling RB1 PDE4D ADCY3 GNA13 CDKN1B SRC CCND3 HRAS MAP2K3 MAP2K1 TSHB KCNIP3 STAT1 SCRIB STAT3 APEX1 PIK3R2 PIK3R1 MTOR CCNE1 MAPK1 GNAO1 RAF1 JAK1 MYL12B MAP2K6 MAPK3 GNAI3 GNAI1 MAPK14 RBL2 RPS6KA1 CDK4 IGF1R CDK2 RAP1GAP RPS6 TSHR RPS6KB1 RAP1A GNB1 CGA GNAS PLCB1 BRAF CREB1 PDPK1 GNG2 RIOK1 AND RIOK2 IN EGFR AND PI3K MEDIATED TUMORIGENESIS%WIKIPATHWAYS_20260810%WP3873%HOMO SAPIENS RIOK1 and RIOK2 in EGFR and PI3K mediated tumorigenesis RICTOR RPL11 MLST8 MTOR FOXO3A AKT3 PTEN EGFR RIOK2 MAPKAP1 RIOK1 PATHWAYS OF NUCLEIC ACID METABOLISM AND INNATE IMMUNE SENSING%WIKIPATHWAYS_20260810%WP4705%HOMO SAPIENS Pathways of nucleic acid metabolism and innate immune sensing IFIH1 RNASEH2C RNASEL RNASEH2B MITA RNASEH2A TREX1 IFNB1 RNASET2 CGAS ADAR MAVS RIGI IRF3 ARYL HYDROCARBON RECEPTOR RESPONSE TO MAIN MEDIATORS PAH AND TCDD%WIKIPATHWAYS_20260810%WP2586%HOMO SAPIENS Aryl hydrocarbon receptor response to main mediators PAH and TCDD RB1 NFKB1 CDKN1B CYP1A2 SRC HRAS MAP2K1 RET TNF RELA NRAS MAPK1 PLAGL1 KLF6 RAF1 CD36 AHRR NFE2L2 NQO1 CYP1A1 CYP1B1 GCLC CCL1 CDK2 AHR MYC EGFR EP300 AIP PTGS2 FGF21 NF1 VEGFA NCOR2 CDC37 LPL CDKN1A CANCER PATHWAYS%WIKIPATHWAYS_20260810%WP5434%HOMO SAPIENS Cancer pathways IGF1 GNGT1 NFKB1 GNGT2 TGFBR1 FGFR2 VEGFB STAT1 STAT3 VEGFC VEGFD CXCR4 CSF3R IL4 JAK1 F2R COL4A6 F2RL3 CAMK2A GNB2 GNB1 PRKACG GNB4 GSTM1 IL7R CREBBP HSP90AB1 SMAD4 IL3RA FOXO1 GNG3 GNG2 GNG5 GNG4 GNA13 GNG7 ARHGEF1 GNG8 SPI1 PTGER4 PTGER1 PTGER2 PTGER3 CTNNA3 ALK CSF1R WNT2B NOTCH1 EPO PDGFA SHH WNT1 IL6R WNT3A HGF WNT7B FLT3LG VEGFA BMP4 IL3 IL6 KITLG KIT IL12B IL12A IFNAR2 IFNA13 IFNA14 GNB3 IFNA16 IFNA17 RET IFNAR1 IFNA10 NKX3-1 IL13 FADD IFNA21 NFKB2 NFKBIA IFNA5 IFNA4 IFNA7 HES1 HES5 CXCL8 IFNA6 IFNA1 IFNA2 JAG2 IFNA8 NCOA1 CASP8 NOTCH2 FOS TRAF3 TRAF6 CXCL12 NOS2 RELA MAPK9 IFNG FLT3 FLT4 MAPK10 ITGA2B RXRG ITGA2 RBX1 SMAD2 ROCK2 ITGA6 CTNNA1 ARNT2 PPARG CKS1B NTRK1 BIRC7 LAMB4 FGFR4 FGFR3 BCR SKP2 RALBP1 RALA RAC3 IFNGR1 NR1C2 IFNGR2 PDGFRA EPOR ITGAV FH TPR PLCG2 PLCG1 CASP9 HEY2 NOTCH3 NOTCH4 WNT8A DLL3 DLL4 NQO1 TRAF1 ARAF MYC EP300 PRKCB STAT5B BRAF KLK3 TNFSF6 BCL2 CYCS RARA GRB2 CDKN1A CAMK2G JAK3 HRAS APAF1 DDB2 TGFBR2 BIRC5 SOS1 SOS2 NRAS STAT4 BAD STAT2 CCNA2 BAX MSH2 TRAF4 SUFU KIF7 CDKN2B CDKN2A IL6ST PIM1 CTBP1 TFG EML4 PAX8 RUNX1T1 Em:AP000351.3 EVI1 PLEKHG5 CCDC42 FZD5 HHIP JUP RUNX1 PTCH2 FZD4 ARHGEF11 ZBTB16 HEL-S-21 FZD8 TRAF2 GLI3 PTCH1 CALML6 CALML3 CALML4 LPAR1 FRAT2 CTNNA2 APC2 TCF7L1 DAPK2 CSF2RB SP1 CEBPA EGFR CCND1 IL15RA ERBB2 CSF2RA TPM3 NR3A2 GSTM4 BCL2L1 HEL-S-125m E2F3 BBC3 BCL2L11 EDNRA NFE2L2 RPS6KA5 LAMA1 PIM2 LAMA3 LAMC2 LAMB3 SMO LAMB1 RPS6KB1 RPS6KB2 IL23A IL12RB1 BRCA2 POLK RALB APC TGFA PLD2 E2F2 BAK1 WNT9A WNT8B PTEN IL7 RASSF1 IL15 RASGRP4 RASGRP3 GNB5 GNAS IL5RA IL2RG RB1 CDKN1B IL5 IL2RA IL2RB LPAR4 CCND3 CCND2 GNA11 CCNE2 CCNE1 PMAIP1 GADD45B GADD45A PML KNG1 GADD45G BDKRB2 AGTR1 CDK6 BDKRB1 RAD51 CDK4 CDK2 MDM2 F2 CRK RARB VHL CCDC6 EGLN3 ELOC DCC MSH3 IL13RA1 BMP2 PTGS2 EGLN2 MMP2 MMP3 IL2 BIRC2 BIRC3 SKP1 IGF2 MAP2K1 MAP2K2 PIK3CD APPL1 PIK3R3 PIK3R2 PIK3R1 MTOR RXRB MAPK1 RAF1 RXRA TRAF5 MAPK3 GNAI3 GNAI1 EDN1 ROCK1 AKT3 TERT FZD10 PLCB3 PLCB4 FRAT1 ARHA PLCB1 PLCB2 MGST3 MGST1 WNT5B MGST2 AXIN1 WNT9B AXIN2 GSTM3 WNT16 GSTM2 CTBP2 HEL-S-22 LEF1 LRP5 GSTM5 LRP6 DVL1 DVL2 DVL3 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A FZD3 FZD2 FZD7 FZD9 WNT7A LAMB2 LAMA4 ITGB1 GSTA5 GSTA4 GSTA3 LAMC1 COL4A2 IGF1R COL4A1 CRKL HDAC2 MAX GSTT2 HDAC1 FGFR1 HMOX1 ADCY3 ADCY1 ADCY8 ADCY6 ADCY5 MSH6 CASP3 ADCY9 RAC1 JUN EGLN1 ARHGEF12 KEAP1 PRKCA HIF1A EDNRB GSK3B CAMK2D TXNRD2 IKBKB MAPK8 CBL IKBKG KPG_010 COL4A4 COL4A3 COL4A5 LPAR2 LPAR3 TGFB1 GNG10 CHUK LAMA5 EGF GNG12 GNG11 GNG13 AUTOPHAGY IN PANCREATIC DUCTAL ADENOCARCINOMA%WIKIPATHWAYS_20260810%WP5331%HOMO SAPIENS Autophagy in pancreatic ductal adenocarcinoma SHOC2 NFKB1 AGER VMP1 IPO8 TFEB MDM2 STAT3 SQSTM1 PINK1 PARK2 HMGB1 NFE2L2 DKFZp762B153 METAPATHWAY BIOTRANSFORMATION PHASE I AND II%WIKIPATHWAYS_20260810%WP702%HOMO SAPIENS Metapathway biotransformation Phase I and II NAT14 LOC51064 HS2ST1 CYP46A1 CYP1A2 SULT1C3 CYP4V2 HYAL3 UGT2A2 UGT2A1 GAL3ST3 GAL3ST4 HEL-S-64p SULT1C4 CHST8 GPX2 HS3ST3B1 CHST9 CHST6 GPX4 CHST7 GPX3 KCNAB1 KCNAB3 CYP2C9 CYP7B1 CYP2A7 BAAT CYP26C1 CHST1 CHST4 NAT8L CHST5 CHST3 HEL-S-75p NAA20 UGT2B28 UGT1A5 CYP2F1 HS3ST5 HS3ST6 CYP2A6 FMO4 HS3ST4 HS3ST1 CYP20A1 GSTM1 CYP2A13 GAL3ST2 CYP51A1 GSTZ1 GSTM4 CYP26B1 SULT2B1 CYP26A1 UGT1A7 AKR1D1 CYP4F3 CYP3A7 SULT2A1 SULT1E1 CYP27A1 CYP2S1 CYP27B1 CYP24A1 CYP2R1 FMO5 HEL-S-166mP UGT1A10 SULT1C2 UGT1A1 UGT1A9 CYP3A43 MGST3 MGST1 MGST2 GSTM3 GSTM2 HEL-S-22 GSTM5 UGT2B15 CYP2C19 SULT1A1 CYP7A1 UGT1A4 UGT2B7 HEL-75 HEL-S-165mP AKR1C1 GSTA5 EPHX1 GSTA4 CYP1A1 GSTA3 CYP1B1 AKR1C2 CYP4F8 AKR1C4 NAT2 CYP3A4 AKR1B1 GSTT2 NNMT TPMT INMT CYP17A1 CYP11B2 CYP21A2 CYP11A1 CYP2E1 GATF-C GLYATL2 CYP2J2 Em:AP000351.3 CYP2B6 UGT1A3 HEL-S-21 HEL-S-75 CYP8B1 HS6ST1 HS6ST2 HS6ST3 CYP4Z1 NDST3 UGT2B11 UGT2B17 CYP2U1 CYP2W1 SULT6B1 HS3ST3A1 CYP4F22 CYP4X1 CHST12 EPHX2 CHST10 CYP4F2 CHST13 CHST14 CYP2C18 CHST11 SULT1A4 SULT1A2 CYP4F12 HS3ST2 NAA50 CYP4F11 SULT1B1 CYP27C1 AKR1B10 NAT8 NAT9 UGT2B4 NAA40 NAT10 MIR TARGETED GENES IN LEUKOCYTES%WIKIPATHWAYS_20260810%WP2003%HOMO SAPIENS miR targeted genes in leukocytes PNP POLE4 GOLGA7 MTHFD2 ATP6V0E1 POM121 PISD TMED10 SERPINE2 DCAF7 ADIPOR2 RTN4 PRSS21 MRPL20 CA12 CHORDC1 CEBPB ATP6V1F HMGA1 CDIPT VPS39 CDK5RAP3 TBCA PPIF TPM3 ARF4 RDH10 TRAM1 ATP2A2 ADAR KCNN4 MRC2 GYS1 SNX6 TUBA1A SPTLC1 PHC2 SH3BGRL3 PRPF40A HEL-S-26 GNA13 SFXN1 LAMTOR3 DNAJB1 POLR2C TMED3 NELFCD CTSC FADS1 AP3D1 ARCN1 MPDU1 SLC7A6 CDCP1 FRG1 FMNL2 PTRH1 MCL1 SRSF10 TNLG5A ARHG WDR11 TUSC2 ARID4B TXN2 ANXA2 HEL-S-66 BCL2 LPL PPIB SLC1A4 MAP3K8 CORO1C SAC3D1 YWHAQ CD164 BRPF3 IGF2R BCL6 MENT SLC25A1 ADPGK TNFAIP2 IFRD1 TMEM109 ACP2 SCYL1 RFT1 ANAPC1 SNAP23 UNC93B1 RAB5C THBS1 CAP1 HEL-S-47e TYMS DDX5 HMOX1 SLC7A11 SHOC2 USP1 TMEM43 PTPA MAPK14 CDK6 PLXND1 LMNB2 HEL-S-30 7Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4932%HOMO SAPIENS 7q11 23 copy number variation syndrome STX1A SNAP25 ATP5G1 HEL-S-271 BTK DLD SQSTM1 ATP8 ATP6 FZD9 ATP5MC2 ATP5MC3 OGDH HEL-S-123m VAMP2 CLDN1 ATP5PB CHTF18 BCL7B ATP5F1D BUD23 ATP5F1E ATPAF2 BRD4 HMGA1 ATP5PO UBE2L6 VPS9D1 UBE2E3 VPS37C VPS37D MYO1C VPS37A CLDN5 HDAC2 VPS37B BAZ1B HDAC3 NUP62 CLIP2 METTL27 FKBP6 ACACA HSPA2 VPS28 ATPAF1 TRIM50 PCNA FBLN2 CLDN4 FBLN5 USF1 MVB12A HOXC8 DDX21 CLASP2 TSG101 SMARCA5 TMEM270 DEK TBL2 RB1 GTF2IRD1 H2AX CLASP1 LAT2 UBE2E1 LIMK1 RFC2 HEL-S-15 GTF2I EIF4H CLTC MLXIPL GRIP1 EIF2A MAPK3 ACACB CDKN1C HEL-S-162eP MYC PKLR ATF4 ABHD11 PRKG1 ULK1 FBN1 MYBBP1A GRB2 NRG1 CLDN3 MONOAMINE TRANSPORT AND REGULATION%WIKIPATHWAYS_20260810%WP727%HOMO SAPIENS Monoamine transport and regulation IL1B HRH3 NECTIN2 SLC6A2 UNC13B TPH2 SLC6A3 IL1R1 TGFB1I1 STX1A TNF SYN1 TSC2 TDO2 ACHE ADORA2A ITGB3 TNFRSF11B TH MAPK14 DBH FBXO32 RBL2 AMPH SLC5A7 IL6 SIGNALING%WIKIPATHWAYS_20260810%WP364%HOMO SAPIENS IL6 signaling VIP BCL2L1 MAP2K1 TYK2 MAP2K2 STAT1 STAT3 VAV1 NR2F6 PIK3R2 NLK SOS1 PIK3R1 IRF-1 MAPK1 BAD RAC1 JAK1 JUNB MAPK3 TIMP1 PTPN11 CRP IL6R GSK3B RPS6KB1 SHC1 NCOA1 HDAC1 MAP3K7 SOCS3 CREBBP IL6 MAP2K4 IL6ST GRB2 RIBOFLAVIN AND COQ DISORDERS%WIKIPATHWAYS_20260810%WP5037%HOMO SAPIENS Riboflavin and CoQ disorders COQ2 FLAD1 SLC52A2 SLC52A1 PDSS1 ETFA COQ8A COQ9 APTX COQ7 COQ6 MYD88 DISTINCT INPUT OUTPUT PATHWAY%WIKIPATHWAYS_20260810%WP3877%HOMO SAPIENS MYD88 distinct input output pathway NFKB1 TRAF6 HEL-S-71 TLR9 MYD88 IL1A TLR8 TLR7 TLR5 TLR4 TLR10 UBE2V1 TIFA IRAK1 JUN TLR1 MOLECULAR PATHWAY FOR OXIDATIVE STRESS%WIKIPATHWAYS_20260810%WP5477%HOMO SAPIENS Molecular pathway for oxidative stress HMOX1 NFKB1 BCL2L1 MAP2K3 NOS2 RHEB CHEK1 TNF NRF1 TSC1 GSX1 IPCEF1 PIP MTOR CCNE1 PTEN MAP3K5 NFE2L2 KEAP1 NQO1 MAPK14 RPS6KA5 IL1A CDK2 MDM2 CXCL8 IKBKB ATF2 PTGS2 ATR MAPK8 IKBKG PINK1 SIRT1 IL6 MAP2K4 CREB1 FOS BCL2 FOXO1 CDKN1A IL18 SIGNALING%WIKIPATHWAYS_20260810%WP4754%HOMO SAPIENS IL18 signaling NFKB1 TRAF6 IL18R1 GRIN2B TNFRSF1A IL18RAP TICAM2 PRKAA1 NCF1 NCF2 TNF IL18 RELA MAPK9 PIK3R1 CASP3 IRF-1 SLC12A3 IMP3 MAPK1 IRAK1 PTEN BAX MAPK3 PRKCA ACACB NFKBIA SP1 MYD88 CEBPB GSK3B CSN2 PARP1 RPS6KB1 IKBKB HEL-S-102 IL37 PRKCB CASP8 MAP3K7 ELAVL1 LCK NFATC4 TNFSF6 CHUK CYCS GATA1 CHEMOKINE SIGNALING%WIKIPATHWAYS_20260810%WP3929%HOMO SAPIENS Chemokine signaling GNGT1 NFKB1 GNGT2 WASL CCL11 CDC42 STAT1 CCR7 PAK1 STAT3 CCR6 CCR4 VAV1 CXCR4 VAV2 TIAM1 CXCL14 CXCL16 DKFZp686L0365 PPBP LYN CCL7 XCL1 CCL1 CCL17 CCL25 CCL24 CCL22 GNB2 CX3CL1 CCL27 CCL15 CCL26 RAP1A GNB1 PRKACG GNB4 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 MAP2K1 PIK3CD PIK3R3 PIK3R2 PIK3R1 PREX1 MAPK1 PARD3 RAF1 ELMO1 DOCK2 PRKX MAPK3 GNAI3 GNAI1 VAV3 CX3CR1 CCR3 CCR2 ROCK1 AKT3 PRKCB PLCB3 PLCB4 STAT5B FOXO3A PLCB1 PLCB2 BRAF CXCR3 CCL19 GRB2 CCL28 PRKCZ JAK3 HRAS GNB3 SOS1 SOS2 NRAS PIK3R5 STAT2 SHC4 NFKBIA SHC2 CXCL11 SHC3 GRK1 CXCL5 IL8RB CRKL CXCL9 c-fgr CCR8 GNB5 SHC1 ITK CCL20 ADCY3 ADCY1 ADCY8 CXCL12 ADCY6 ADRBK1 NCF1 ADCY5 RELA CCL5 CCL4 CCL3 PTK2B ADCY9 RAC1 PF4 GRK5 GRK4 CXCL13 CXCR5 GSK3B ROCK2 CCL21 CXCL3 CXCR6 IKBKB IKBKG CRK CSK PXN WAS CCR10 GNG10 CCR1 CHUK XCR1 GNG12 GNG11 NFKBIB GNG13 AGE RELATED MACULAR DEGENERATION%WIKIPATHWAYS_20260810%WP5526%HOMO SAPIENS Age related macular degeneration RPTOR PARP2 PRKAA2 PRKAA1 RPS6KB1 PRKAB2 MTOR MLST8 PRKAG1 PRKAG2 SIRT1 PPARGC1A HEL-S-32 PMAIP1 PRKAB1 PRKAG3 MAPK3 DOCOSAHEXAENOIC ACID OXYLIPIN METABOLISM%WIKIPATHWAYS_20260810%WP5154%HOMO SAPIENS Docosahexaenoic acid oxylipin metabolism EPHX2 PTGS2 CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260810%WP5304%HOMO SAPIENS Cholesterol metabolism MVK APOB LDLR MSMO1 ACAT2 TM7SF2 EBP SC5D VAPA MYLIP STARD3 CYP7A1 DHCR24 SOAT1 ABCG8 ABCG5 APOC3 APOC1 NPC1L1 CD36 DGAT1 HMGCS1 IDI1 PBR DKFZp434B2017 SORT1 FDFT1 LIPA FDPS CYP51A1 SQLE STAR APOA4 PLTP MGAT1 NPC1 NPC2 ABCB11 LBR MVD CYP27A1 HSD17B7 LPA DHCR7 LRPAP1 APOH CIDEB FABP2 ANGPTL8 ANGPTL3 SLC27A4 ABCA1 SCARB1 MTTP APOA2 PCSK9 LPL LIPC HMGCR APOC2 LIPG APOE MICROGLIA PATHOGEN PHAGOCYTOSIS PATHWAY%WIKIPATHWAYS_20260810%WP3937%HOMO SAPIENS Microglia pathogen phagocytosis pathway LAT NCF1 NCF2 NCF4 PIK3CD ARPC1B PIK3R3 VAV1 PIK3R2 VAV2 PIK3R1 RAC3 CYBB ITGAM CYBA C1QB RAC1 C1QA PTPN6 NCKAP1L FCGR1A VAV3 LYN SIGLEC7 C1QC FCER1G TYROBP TREM1 PLCG2 SYK FAMILIAL PARTIAL LIPODYSTROPHY%WIKIPATHWAYS_20260810%WP5102%HOMO SAPIENS Familial partial lipodystrophy KLF9 MAPK9 LIPE PLIN1 NR1C1 PRRX1 INS CIDEA HEL-S-104 CIDEC MGLL CEBPA KLF2 ICMT PNPLA2 LMNB2 ZMPSTE24 FNTA LMNA STAT5B GATA3 GATA2 PPARG BANF1 LPL KLF5 BENZENE METABOLISM%WIKIPATHWAYS_20260810%WP3891%HOMO SAPIENS Benzene metabolism NQO1 EPHX1 GSTM1 DHDH CYP2E1 MPO MITOCHONDRIAL BETA OXIDATION%WIKIPATHWAYS_20260810%WP5241%HOMO SAPIENS Mitochondrial beta oxidation DECR1 ACADL EHHADH HSD17B10 ACADSB ACSL3 ECHS1 MFAP5 MEDIATED OVARIAN CANCER CELL MOTILITY AND INVASIVENESS%WIKIPATHWAYS_20260810%WP3301%HOMO SAPIENS MFAP5 mediated ovarian cancer cell motility and invasiveness RYR3 MAPK1 PLCG1 CREB1 MFAP5 TNNC1 JUN MAPK3 ITGB3 PRKCQ ITGAV MALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260810%WP5320%HOMO SAPIENS Male steroid hormones in cardiomyocyte energy metabolism UGT1A1 HSD3B2 SRD5A2 HSD17B2 HSD3B1 HSD17B3 CYP17A1 SULT1A1 CYP11A1 SMC1 SMC3 ROLE IN DNA DAMAGE CORNELIA DE LANGE SYNDROME%WIKIPATHWAYS_20260810%WP5118%HOMO SAPIENS SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome RAD18 MDC1 RAD50 SMC3 PAXIP1 RAD21 ATM MRE11A NBN SMC1A HEMATOPOIETIC STEM CELL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2849%HOMO SAPIENS Hematopoietic stem cell differentiation LYL1 LEF1 HES6 VAV1 CXCR4 ITGB3 CSF3 XB NR1A2 CSF2 FOS ARHH IL1B PIM1 IL5 CD34 SPI1 ITGA2B NOTCH1 CSF1 EPO NCKAP1L RUNX1 MYB TPO IL1A TRAF3IP3 IKZF1 HMGN5 TRIM29 LMO2 CBFA2T3 ZNF835 ACVR1B ABO MUC1 GATA2 MXI1 FOSB NFE2 IL3 RIOK3 IL6 MHC2TA KITLG FLI1 KLF1 GP9 GATA1 NFATC2 IL4 SIGNALING%WIKIPATHWAYS_20260810%WP395%HOMO SAPIENS IL4 signaling NFKB1 JAK3 TYK2 PIK3CD STAT1 STAT3 RELA PIK3R2 SOS1 PIK3R1 INPP5D IL4 MAPK1 SOCS1 BAD SOCS5 JAK1 MAPK11 MAPK3 PTPN6 IRS1 PTPN11 NFKBIA MAPK14 CEBPA CEBPB FLNA RPS6KB1 IKBKB EP300 ATF2 FES CBL SHC1 STAT5B SOCS3 CHUK FOS GRB2 IL2RG GAB2 GPR40 ROLE IN INSULIN SECRETION%WIKIPATHWAYS_20260810%WP3958%HOMO SAPIENS GPR40 role in insulin secretion PLCB1 PLCG2 PLCB2 PLCE1 PKD1 PLCG1 FFAR1 PLCD3 PLCH1 PLCL1 PLCB3 GNA11 ROLES OF CERAMIDES IN DEVELOPMENT OF INSULIN RESISTANCE%WIKIPATHWAYS_20260810%WP5181%HOMO SAPIENS Roles of ceramides in development of insulin resistance TRAF1 TNFRSF1A PRKCZ EIF2AK2 PPP2CA TNF RPS6KB1 PDX1 MAPK8 ACSL1 PIK3R1 ERN1 CD36 INSR PRKAG3 MAFA IRS1 SLC2A4 INS BASE EXCISION REPAIR%WIKIPATHWAYS_20260810%WP4752%HOMO SAPIENS Base excision repair UNG NTHL1 POLD3 MUTYH POLD4 POLG MBD4 PARP3 PARP4 RFC3 ADPRHL2 RFC4 NEIL3 LIG1 POLG2 POLD2 RFC2 APTX NEIL1 APEX1 RFC1 POLE4 TDG POLE2 HMGB1 POLE3 SMUG1 FEN1 POLL PARP2 PARP1 POLE TDP1 PCNA NEIL2 MPG OGG1 PNKP WNT BETA CATENIN SIGNALING INHIBITORS IN CURRENT AND PAST CLINICAL TRIALS%WIKIPATHWAYS_20260810%WP5442%HOMO SAPIENS Wnt Beta catenin signaling inhibitors in current and past clinical trials LRP5 CREBBP LRP6 PORCN PATHWAYS AFFECTED IN ADENOID CYSTIC CARCINOMA%WIKIPATHWAYS_20260810%WP3651%HOMO SAPIENS Pathways affected in adenoid cystic carcinoma HRAS JMJD1C HIST1H1E MYBL1 CMTR2 MAGI1 HIST1H2AK INSRR FOXP2 MAML3 MORF4L1 KAT6A DTX4 MYCBP SRCAP PTEN MGA KANSL1 ARID1A KDM6B BCOR FBXW7 CEBPA FGF16 MAX ERBB2 CREBBP NFIB UHRF1 CHEK2 ERBIN CHEK1 MAP2K2 CTBP1 TLK1 ARID5B SMC1A BCORL1 PRKDC RAF1 NOTCH1 SETD2 MYB NCOR1 KMT2C MYC ATM EP300 ARID4B FOXO3A SMARCE1 FGFR4 MEVALONATE ARM OF CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260810%WP4190%HOMO SAPIENS Mevalonate arm of cholesterol biosynthesis pathway FDPS MVK HMGCS1 IDI2 IDI1 ACAT2 HMGCL GGPS1 ACAT1 HMGCR MVD FDFT1 AGE RAGE PATHWAY%WIKIPATHWAYS_20260810%WP2324%HOMO SAPIENS AGE RAGE pathway NFKB1 PRKCZ MMP9 CDC42 STAT1 STAT3 EZR HEL70 MSR1 INHBB NFKBIA HEL-S-44 SP1 MYD88 FOXO4 EGFR ATF2 CASP8 MMP2 SHC1 IRAK4 TIRAP FOXO1 CASP9 DDOST SRC MAP2K1 NCF1 NOS2 RELA MAPK9 CASP3 MAPK1 RAF1 RAC1 JUN MAPK3 IRS1 PRKCA HIF1A INS MAPK14 AGER ROCK1 ALPL SMAD2 IKBKB PRKCB MAPK8 MMP14 ARHA STAT5B MMP7 INSR CHUK CYCS MAMMARY GLAND DEVELOPMENT INVOLUTION STAGE 4 OF 4%WIKIPATHWAYS_20260810%WP2815%HOMO SAPIENS Mammary gland development involution stage 4 of 4 SOCS3 BAX MMP9 MYC IL6ST STAT3 CHI3L1 FGFR3 SIGNALING IN CHONDROCYTE PROLIFERATION AND TERMINAL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP4767%HOMO SAPIENS FGFR3 signaling in chondrocyte proliferation and terminal differentiation SOX9 MAP2K1 CNP PPP2CA MAP2K2 STAT1 IHH MAPK1 MAPK12 RAF1 MAPK13 MAPK11 BMP2 FGF9 MAPK3 NPR2 PTH1R MAPK14 THRA PTHLH SNAI1 RBL1 DKFZp686F0183 FGF18 BMP4 FGFR3 CDKN1A HOMOLOGOUS RECOMBINATION%WIKIPATHWAYS_20260810%WP186%HOMO SAPIENS Homologous recombination RAD52 POLD3 RAD50 POLD4 RAD51 BRCA2 POLD2 RPA1 ATM MRE11A NBN RAD54B UDP DERIVED SUGARS SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260810%WP5394%HOMO SAPIENS UDP derived sugars synthesis in fibroblasts UGDH GFPT1 HK3 GCK HK2 UXS1 PGM3 DIFFERENTIATION OF WHITE AND BROWN ADIPOCYTE%WIKIPATHWAYS_20260810%WP2895%HOMO SAPIENS Differentiation of white and brown adipocyte HSPB7 CIDEA EBF3 ZNF423 SLC7A10 HOXC9 MPZL2 CEBPA CEBPB LEP DKFZp781O1323 PRDM16 BMP4 PPARG PPARGC1A SMAD1 SMAD9 BMP2 HOXC8 PPARGC1B CEBPG BMP7 ZIC1 DGIC DNA DAMAGE RESPONSE ONLY ATM DEPENDENT %WIKIPATHWAYS_20260810%WP710%HOMO SAPIENS DNA damage response only ATM dependent LDLR G6PC1 NFKB1 LEF1 HRAS APC BCL6 TP73 DVL1 CDC42 DVL2 BAK1 DVL3 WNT3 WNT4 SOS1 SOS2 WNT10B TCF7L2 WNT10A NRAS RAC3 PIK3R5 BAD TCF7L1 PTEN BAX PIK3R4 WNT7A PIK3C2G HMGB1 FOSL1 NFKB2 PIK3C2B RBL2 MLKL BIK CCNG2 CCND1 CDKN2A SHC1 ERBB2 SMAD4 CDKN1B CCND3 CCND2 PIK3CD PIK3R3 BBC3 PIK3R2 MAPK9 PIK3R1 BCL2L11 MAPK1 RAC1 PMAIP1 MAPK10 WNT2B JUN IRS1 PCK2 WNT1 AKT3 GSK3B MDM2 MYC WNT3A ATM WNT7B FRAT1 MAPK8 PPP2R5E ARHA FOXO3A MAP3K7 WNT5B AXIN1 TGFB1 MAP3K1 INSR TNFSF6 BCL2 PPP2R5C WNT16 GRB2 CDKN1A ATR SIGNALING%WIKIPATHWAYS_20260810%WP3875%HOMO SAPIENS ATR signaling TOPBP1 RAD9B ATRIP CHEK1 HUS1 RAD1 RPA1 RAD9A RPA3 ATR GLUCOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5280%HOMO SAPIENS Glucocorticoid biosynthesis AKR1D1 AKR1C2 AKR1C4 SRD5A2 CYP3A4 HSD11B1 HSD11B2 CYP11B2 CYP21A2 AKR1C1 INTEGRATED CANCER PATHWAY%WIKIPATHWAYS_20260810%WP1971%HOMO SAPIENS Integrated cancer pathway RB1 CDKN1B CHEK2 CHEK1 STAT1 MSH6 BBC3 CASP3 BAD PTEN JAK1 CDC25B BAX MSH2 MAP3K5 BLM PLK1 MRE11A CDC2 RAD50 NOXA1 BACH1 CDK4 SMAD2 CDK2 MDM2 POU2F1 MYC ATM ATF1 CDKN2B ATR CASP8 BCL2 CDKN1A CASP9 BARD1 EXTRACELLULAR VESICLE MEDIATED SIGNALING IN RECIPIENT CELLS%WIKIPATHWAYS_20260810%WP2870%HOMO SAPIENS Extracellular vesicle mediated signaling in recipient cells TGFBR1 HRAS SMAD2 TGFA APC DKK4 WNT3A HGF TGFBR2 MFGE8 EGFR ERBB2 MTOR NRAS SMAD4 RAF1 AXIN1 TGFB1 TSPAN8 CD133 TGFBR3 INTEGRIN MEDIATED CELL ADHESION%WIKIPATHWAYS_20260810%WP185%HOMO SAPIENS Integrin mediated cell adhesion HRAS CDC42 MYLK2 PAK1 VAV2 SOS1 RAC3 CAPN3 VASP CAV2 ITGB3 ITGAV ITGB1 ITGA1 SHC3 RAPGEF1 DOCK1 CAPN9 ZYX CAPN6 ITGB6 CAPN7 MYPN CAPN5 TNS1 ARHGEF7 RAP1A GIT2 SHC1 CAPN11 RHO SRC ITGB4 MAP2K3 MAP2K1 MAP2K2 SELENOP PIK3R2 CAPN10 MAPK1 ITGAM RAF1 FYN MAPK12 RAC1 MAPK10 ITGA2B MAP2K6 ITGAE ITGAX VAV3 ITGB8 ITGB7 HEL114 ITGA4 MAPK6 ITGA2 ROCK1 MAPK4 ARAF AKT3 ITGA7 ROCK2 ITGA6 MAPK7 HEL-S-28 CRK CSK PXN PAK6 MAP2K5 PAK4 BRAF TLN1 PDPK1 GRB2 CAV3 ONCOSTATIN M SIGNALING%WIKIPATHWAYS_20260810%WP2374%HOMO SAPIENS Oncostatin M signaling NFKB1 JAK3 OSMR HRAS TYK2 STAT1 OSM STAT3 SOS1 JAK1 NFKBIA CEBPB EGR1 SHC1 SOCS3 CREB1 FOS IL6ST CDKN1B SRC MAP2K1 JUND MAP2K2 RELA MAPK9 CASP3 PIK3R1 MTOR PTK2B MAPK1 RAF1 JUNB MAPK3 IRS1 PRKCA HIF1A PTPN11 RICTOR MAPK14 CDK2 RPS6 PRKCB MAPK8 STAT5B VEGFA PRKCH PXN PRKCE GRB2 SILDENAFIL TREATMENT%WIKIPATHWAYS_20260810%WP5294%HOMO SAPIENS Sildenafil treatment PDE4D HEL-S-162eP TFAM PDE5A AKT3 GSK3B GUCY1B1 NOS2 NRF1 ZNF746 PRKG1 PPARGC1A PARK2 PDE4B PDE4A GUCY1A2 UROTENSIN II MEDIATED SIGNALING%WIKIPATHWAYS_20260810%WP5158%HOMO SAPIENS Urotensin II mediated signaling AIFM2 NFKB1 MMP9 STAT3 ACTA2 PTEN BAX GSK3A COL3A1 NPPB CAMK2A HDAC5 EGFR UTS2R NOX4 MMP2 TRPC4 HSPA2 CREBBP PCNA UTS2 CASP9 IRF3 IL1B HMOX1 NCF1 NCF2 COL2A1 NCF4 TNF RELA MAPK9 CASP3 ALOX5 CCNE1 CYBB ESPL1 DDIT3 MAPK1 CYBA MAPK3 VCAM1 PTPN11 CDC2 MAPK14 AGTR1 COL1A1 SMAD2 CDK2 GSK3B IKBKB EP300 MAPK8 NPPA ARHA PLN ABCA1 IL6 TGFB1 CHUK BCL2 UREA CYCLE AND RELATED DISEASES%WIKIPATHWAYS_20260810%WP4571%HOMO SAPIENS Urea cycle and related diseases SLC25A13 OTC GLS2 ARG1 ASS1 SLC25A15 ASL NAGS MIRNA REGULATION OF P53 PATHWAY IN PROSTATE CANCER%WIKIPATHWAYS_20260810%WP3982%HOMO SAPIENS miRNA regulation of p53 pathway in prostate cancer TP53AIP1 APAF1 CHEK2 MDM2 DDB2 ATM BBC3 CASP3 CASP8 EI24 SHISA5 CYS1 PTEN SESN3 PMAIP1 BAX SIAH1 TNFRSF10B CASP9 ZMAT3 PERP HEDGEHOG SIGNALING%WIKIPATHWAYS_20260810%WP47%HOMO SAPIENS Hedgehog signaling DHH SUFU PTCH2 SHH KIF7 ADRBK1 GLI3 PTCH1 SAP18 SMO SIN3A IHH GLUTATHIONE METABOLISM%WIKIPATHWAYS_20260810%WP100%HOMO SAPIENS Glutathione metabolism HEL-S-26 GCLC GCLM HEL-S-64p GPX2 GPX1 GPX4 GPX3 GSTM1 GSTT2 HEL-75 OPLAH GSTM2 GSTA5 THIAMINE METABOLIC PATHWAYS%WIKIPATHWAYS_20260810%WP4297%HOMO SAPIENS Thiamine metabolic pathways PDHA1 SLC19A2 BCKDK HEL107 OGDH SLC19A3 DKFZp667O1614 ETHER LIPID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5275%HOMO SAPIENS Ether lipid biosynthesis PEDS1 PEX7 PEX5L ALDH3A2 PEX3 DHRS7B AGMO ACAD10 LPIN3 PEX19 UGT8 FAR1 CEPT1 GNPAT LPIN1 LPIN2 PEX16 LPCAT1 TGF BETA RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP560%HOMO SAPIENS TGF beta receptor signaling NFKB1 TGFBR1 LEF1 HRAS TGFBR2 STAT1 STAT3 JAK1 ZFYVE9 RUNX2 TGIF1 SMAD6 TGFBR3 ENG LTBP1 ZNF423 THBS1 FKBP1A SKI BAMBI DKFZp781O1323 ITGB6 ZEB2 CREBBP SMAD4 SMAD1 SMAD9 FOS opn TNF FOXH1 LIF MAPK9 IFNG JUN MAPK3 SKIL WNT1 SMAD2 LEFTY1 RUNX3 EP300 FST NOG INHBA BMP4 LEFTY2 TGFB1 EGF COVID 19 ADVERSE OUTCOME PATHWAY%WIKIPATHWAYS_20260810%WP4891%HOMO SAPIENS COVID 19 adverse outcome pathway CSF3 IL1B IL2RA TMPRSS2 CXCL8 TNF ACE2 IL2 CCL3 CCL2 IL6 IL10 IL7 MRNA PROCESSING%WIKIPATHWAYS_20260810%WP411%HOMO SAPIENS mRNA processing RBM17 PRMT2 NCBP1 NCBP2 PRPF18 POLR2A NHP2L1 HNRNPH1 SNRPA1 DNAJC8 SF3B5 SF3B2 CSTF2T U2AF1 PPM1G PABPN1 U2AF2 TRA2B SPOP SNRPB2 SF3A1 SNRPN SF3A2 SUPT5H HNRNPAB NUDT21 PHF5A HNRNPA2B1 RBMX SRSF9 TMED10 NONO CLK2 PRPF40A SRPK2 DHX15 SRSF10 RNMT YBX1 PTBP1 METTL3 PRMT1 HNRNPR SNRPD2 SNRPD1 CLP1 PAPOLA FUS SNRPD3 TXNL4A PSKH1 SMC1A PRP4K CDC40 HNRNPD PRPF4 PRPF6 PRPF3 SNRPG CD2BP2 SRSF4 SNRPE SNRPF SREK1 SRSF6 SRSF7 SNRPA SNRPB DICER1 DHX8 DDX1 CSTF3 CSTF2 PRPF8 SFRS5 SFPQ SFRS8 CSTF1 DHX38 CPSF4 CPSF1 CPSF3 CPSF2 WDR57 SFRS3 CLK4 LSM2 SRPK1 HNRNPL CLK1 LSM7 RNPS1 CLASRP HNRNPC DKFZp434N041 SUGP2 SUGP1 CELF1 CELF2 CELF4 SRP54 DHX16 RBM5 TYPE I INTERFERON INDUCTION AND SIGNALING DURING SARS COV 2 INFECTION%WIKIPATHWAYS_20260810%WP4868%HOMO SAPIENS Type I interferon induction and signaling during SARS CoV 2 infection IFIH1 TRAF6 IFNAR2 TLR9 IRF7 TLR7 TMPRSS2 EIF2AK2 TYK2 TLR4 TLR3 STAT1 ACE2 IFNAR1 IRF9 STAT2 JAK1 TREML4 OAS3 OAS2 MYD88 IKBKE MAVS IRAK4 RIGI TBK1 IRF3 TRAF3 PHYSICO CHEMICAL FEATURES AND TOXICITY ASSOCIATED PATHWAYS%WIKIPATHWAYS_20260810%WP3680%HOMO SAPIENS Physico chemical features and toxicity associated pathways TGFA APC PPP2CA DVL1 PAK1 GPX1 MYLK SOS1 FZD1 FZD3 FZD2 FZD7 FZD9 ACTR3 DAAM1 PFN4 PFN2 PFN1 HEL-S-44 EGFR PFN3 NEFL ERBB4 SHC1 ERBB2 PLCG1 CDKN1B SRC MAP2K1 ACTR2 MAPK1 RAF1 JUN FZD5 FZD4 NEF3 FZD8 NEFH GSK3B NCK1 ROCK2 MYC TMSB4X FZD10 MAPK8 CBL ARHA CAMK1 MAP2K4 AXIN1 WNT16 ACTA1 GRB2 CDKN1A MYL1 KISSPEPTIN KISSPEPTIN RECEPTOR SYSTEM IN THE OVARY%WIKIPATHWAYS_20260810%WP4871%HOMO SAPIENS Kisspeptin kisspeptin receptor system in the ovary NFKB1 HRAS MAP2K1 MMP9 MAP2K2 FSHR PIK3CD NRAS MAPK1 DKFZp686L0365 RAF1 MAPK3 PRKCA BMP15 KISS1R AMH PRKCB PLCB3 PLCB4 PLCB1 PRKCH PLCB2 PRKCE HSD3B1 KISS1 STAR PRKCQ CYP11A1 OMEGA 3 OMEGA 6 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260810%WP4723%HOMO SAPIENS Omega 3 omega 6 fatty acid synthesis ELOVL2 FACL4 PLA2G5 ACOX1 FADS1 PLA2G6 ACSL3 FADS2 ELOVL5 PLA2G4B ACOX3 ACSL1 DICLOFENAC METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP2491%HOMO SAPIENS Diclofenac metabolic pathway CYP2C9 CYP2C18 CYP2C19 CYP2B6 TCA CYCLE NUTRIENT USE AND INVASIVENESS OF OVARIAN CANCER%WIKIPATHWAYS_20260810%WP2868%HOMO SAPIENS TCA cycle nutrient use and invasiveness of ovarian cancer MAPK1 JAK1 MAPK3 STAT3 EGFR DISORDERS OF GALACTOSE METABOLISM %WIKIPATHWAYS_20260810%WP5173%HOMO SAPIENS Disorders of galactose metabolism GYS2 HEL-S-19 PYGL GYG1 SLC5A1 SLC2A2 GYS1 AKR1B1 ULCERATIVE COLITIS SIGNALING%WIKIPATHWAYS_20260810%WP5174%HOMO SAPIENS Ulcerative colitis signaling NFKB1 IL5 TNF MAF GATA3 IL4 HLA-DMA IFNG NFATC1 IL10 TGFB1 IL13 NOD2 FOXP3 IL2RG CANONICAL NF KB PATHWAY%WIKIPATHWAYS_20260810%WP4562%HOMO SAPIENS Canonical NF kB pathway IKBKG NFKB1 NFKBIE REL CHUK IKBKB RELA NFKBIA IL5 SIGNALING%WIKIPATHWAYS_20260810%WP127%HOMO SAPIENS IL5 signaling SPRED1 MAP2K1 MAP2K2 STAT1 STAT3 PIK3R2 BTK SOS1 PIK3R1 MAPK1 RAF1 JAK1 JUN MAPK3 GSK3A CSF2RB PTPN11 LYN RPS6KA1 GSK3B RPS6 RPS6KB1 RPS6KB2 SHC1 STAT5B FOXO3A IL2 SYK GRB2 IL5RA CONGENITAL GENERALIZED LIPODYSTROPHY%WIKIPATHWAYS_20260810%WP5101%HOMO SAPIENS Congenital generalized lipodystrophy CAVIN1 BSCL2 ITGB4 LPIN3 HMFN0839 FYN LPIN1 LPIN2 DGAT2 DGAT1 GRB2 IRS1 HIF1A INS FATTY ACID AND LIPOPROTEIN TRANSPORT IN HEPATOCYTES%WIKIPATHWAYS_20260810%WP5323%HOMO SAPIENS Fatty acid and lipoprotein transport in hepatocytes APOB LDLR APOA4 MYLIP SLC27A2 STARD3 NPC2 ACSL3 SOAT1 ACSL1 APOC1 LPA SLC27A1 FABP2 DBI HEL-S-104 FABP1 SLC27A3 SLC27A4 SORT1 LIPA ACSL6 ACSL5 ABCA1 SCARB1 PCSK9 SOAT2 STAR APOC2 APOE DISORDERS OF NAD METABOLISM%WIKIPATHWAYS_20260810%WP5506%HOMO SAPIENS Disorders of NAD metabolism BST1 NAXE NAXD NADSYN1 GDNF SIGNALING%WIKIPATHWAYS_20260810%WP5143%HOMO SAPIENS GDNF signaling GASTRIN SIGNALING%WIKIPATHWAYS_20260810%WP4659%HOMO SAPIENS Gastrin signaling NFKB1 PRKD1 CDC42 PAK1 STAT3 DKFZp686L0365 BMP2 SP1 MEF2B EGFR ARHGEF28 PTGS2 CCND1 GAST IL2 PLCG1 ELAVL1 CREB1 BIRC2 BIRC3 YES1 FOXO1 RHOD RHOB BCL2L1 LAMTOR3 MAP2K1 PIK3R3 PIK3R2 PIK3R1 TFF2 MTOR EIF4EBP1 MAPK1 RAF1 MAP3K11 MAPK3 TJP1 IRS1 ROCK1 MEF2C TCF4 CCKBR MYC RPS6 SLC9A3 RPS6KB1 ARHA FOXO3A MMP7 VEGFA PRKCH PRKCE ANXA2 KIT GRB2 PRKCQ CDKN1A CD44 HRAS BIRC5 SOS1 SERPINB2 BAD HDC NFKBIA ITGB1 MEF2D CLDN1 CXCL8 KLF4 ATF2 EGR1 CDKN2A SHC1 HDAC7 FOS KAT5 CDKN1B SRC RELA MAPK9 CASP3 FYN RAC1 JUN PRKCA PTPN11 MAPK14 GSK3B IKBKB MAPK8 CRK PXN PPARG CHUK PRKD2 GLUCOCORTICOID RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2880%HOMO SAPIENS Glucocorticoid receptor pathway FGD4 CPEB4 EPB41L4B ENC1 EDN2 S100P TSC22D3 NR1i2 CDC42EP3 PMP2 B3GNT5 GPR153 SERTAD2 CAVIN2 PTGES3 TGFBR3 KTN1 NFKB2 RGS2 DNER SLC19A2 NR3C1 PTGS2 TNFAIP3 SCNN1A MGAM SLC26A2 ANKRD1 ABHD2 CCL20 DNAJC15 BIRC2 BIRC3 SNAI2 ARL5B SRGN TNS4 NAV3 ADGRF4 PRRG4 FGFBP1 STOM PPP1R14C MFGE8 ACKR3 CCL2 ALOX5AP RXRA JUN AMIGO2 GADD45B CDKN1C THBD ZIC2 NR1I3 IL11 ANGPTL4 BHLHB2 PDE4B POU5F1 PLK2 SPRY1 TROP2 REGULATORY SIGNALING%WIKIPATHWAYS_20260810%WP5300%HOMO SAPIENS TROP2 regulatory signaling RB1 IGF1 IGF2 NFKB1 CLDN7 CDKN1B SRC IGF2R CHEK1 STAT1 PIK3R1 CCNE1 RAC1 PTEN BAX NOTCH1 JUN ABCC1 PRKCA ITGB1 HEL113 PECAM1 CLDN1 CDK4 IGF1R CDK2 EGFR CCND1 MDK TACSTD2 CDKN2A PSEN2 PAK4 BCL2 TLN1 ACVRL1 MAMMALIAN DISORDER OF SEXUAL DEVELOPMENT%WIKIPATHWAYS_20260810%WP4842%HOMO SAPIENS Mammalian disorder of sexual development EMX2 SOX9 PBX1 WT1 NR5A1 FGFR2 SOX8 AMH FST WNT4 DMRT1 DHH RBFOX2 FOXL2 AMHR2 SRY CBX2 INSL3 GATA4 MAPK11 FGF9 RSPO1 MAP3K1 ROLE IN PROMOTING AND BLOCKING GONADAL DETERMINATION%WIKIPATHWAYS_20260810%WP4872%HOMO SAPIENS MAP3K1 role in promoting and blocking gonadal determination GADD45G SOX9 ROCK1 GSK3B FGFR2 FRAT1 WNT4 ARHA FOXL2 SRY MAPK1 AXIN1 MAP3K1 MAPK11 FGF9 CYTOKINES AND INFLAMMATORY RESPONSE%WIKIPATHWAYS_20260810%WP530%HOMO SAPIENS Cytokines and inflammatory response CSF3 IL1B HLA-DRB1 IL5 CXCL1 IL1A IL11 CSF2 TNF CXCL2 IL2 IL4 IFNB1 IFNG IL3 IL6 IL10 TGFB1 IL13 CSF1 IL7 PDGFA IL15 IL12B 10Q11 21Q11 23 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5352%HOMO SAPIENS 10q11 21q11 23 copy number variation syndrome DRGX KDM4D C10orf53 NLRP3 RGMB SLC18A3 TMEM273 WDFY4 HSF1 JUND MEN1 UVSSA DLD BMP2 CUL5 ERCC5 DKFZp781O1323 ATF2 MYO1C MAPK8 NOG BAZ1B SIRT6 BMPR1A GDF5 SIRT1 PARG ITCH PCNA LRRC18 SMAD1 RIF1 SMARCC2 SMAD9 OGDHL ARHGAP22 ChAT MYBBP1A EIF4ENIF1 BCL2 DDX21 HSF4 FAM170B SMARCA5 ELOA CEFIP DEK VSTM4 ACTIVATION OF NLRP3 INFLAMMASOME BY SARS COV 2%WIKIPATHWAYS_20260810%WP4876%HOMO SAPIENS Activation of NLRP3 inflammasome by SARS CoV 2 IL1B NFKB1 NLRP3 RELA PYCARD TRAF3 BIOSYNTHESIS AND TURNOVER OF 1 DEOXY SPHINGOID BASES%WIKIPATHWAYS_20260810%WP5179%HOMO SAPIENS Biosynthesis and turnover of 1 deoxy sphingoid bases SPTLC2 KDSR SPHK2 SGPP2 SPTLC1 SPHK1 SGPP1 UTERINE NATURAL KILLER CELLS AND PROGESTERONE ESTROGEN AND CHORIONIC GONADOTROPIN%WIKIPATHWAYS_20260810%WP5569%HOMO SAPIENS Uterine natural killer cells and progesterone estrogen and chorionic gonadotropin JAK3 HLA-G CXCR4 IL4 JAK1 IL15 KIR2DL4 CD69 CXCL11 CCL8 CCL7 CXCL8 NR3C1 CX3CL1 SELL IL15RA NR3A2 IL2RG PGR IL2RB CXCL12 MRC1 MADCAM1 GAB3 NCR1 NCR2 TNF NCR3 CCL5 CCL4 CCL3 IFNG CCL2 IL10 MCL1 MAPK11 MAPK3 VCAM1 ITGA4 PIBF1 STAT5B VEGFA GATA2 IL3 IL6 MAP2K4 ANGPT1 ANGPT2 BCL2 CXCR3 ERBB SIGNALING%WIKIPATHWAYS_20260810%WP673%HOMO SAPIENS ErbB signaling CAMK2G HRAS TGFA PAK1 SOS1 SOS2 NRAS BAD NRG2 SHC4 SHC2 SHC3 CRKL CAMK2A EGFR ABL2 CCND1 ERBB3 ERBB4 SHC1 ERBB2 PLCG2 AREG FOXO1 NCK2 CDKN1B SRC MAP2K1 MAP2K2 PIK3CD EREG PIK3R3 NRG3 NRG4 PIK3R2 MAPK9 PIK3R1 BCL2L11 MTOR EIF4EBP1 MAPK1 RAF1 MAPK10 BTC JUN MAPK3 HBEGF PRKCA ARAF AKT3 GSK3B NCK1 MDM2 CAMK2D MYC RPS6KB1 RPS6KB2 PRKCB MAPK8 CBL CRK STAT5B PAK6 PAK4 BRAF MAP2K4 EGF PDPK1 GRB2 CDKN1A NRG1 SYNTHESIS OF CERAMIDES AND 1 DEOXYCERAMIDES%WIKIPATHWAYS_20260810%WP5194%HOMO SAPIENS Synthesis of ceramides and 1 deoxyceramides B4GALT1 CERS3 CERS6 CERK SGMS1 SGMS2 LASS1 CERS5 UGT8 UGCG A4GALT KDSR CERS2 B3GNT5 DGAT1 SPHK1 SPTLC1 DES B4GALNT1 A3GALT2 KETOGENIC DIET IN EPILEPTOGENESIS%WIKIPATHWAYS_20260810%WP5639%HOMO SAPIENS Ketogenic diet in epileptogenesis HMGCS1 NLRP3 HEL-S-133P AKT3 RPS6 GLUD1 HDAC2 SIRT4 HDAC3 ERBB4 ABCC8 KCNA1 SLC25A14 HDAC1 HCAR2 TXNIP GAD1 PPARG HDAC8 UCP2 NFE2L2 SLC25A27 NRG1 AIRWAY SMOOTH MUSCLE CELL CONTRACTION%WIKIPATHWAYS_20260810%WP4962%HOMO SAPIENS Airway smooth muscle cell contraction HEL-S-80p GDI1 ROCK1 CALM1 ROCK2 RYR1 ADRB2 MYLK ARHA PLCB1 PPP1R14A IL13 MYL1 RANKL RANK SIGNALING%WIKIPATHWAYS_20260810%WP2018%HOMO SAPIENS RANKL RANK signaling NFKB1 TRAF6 SRC MAP2K1 SPI1 CDC42 STAT1 RELA PIK3R2 MAPK9 PIK3R1 SQSTM1 MTOR PAPSS2 MAPK1 RAC1 MAP2K6 MAP3K7IP1 JUN MAPK3 TRAF5 NFKB2 TNFRSF11B LYN NFKBIA MAPK14 TRAF1 TNFSF11 TNFRSF11A IKBKB MAPK8 RELB CBL TRAF2 IKBKG MAP3K7 FHL2 NFATC1 PLCG1 SYK CHUK FOS GAB2 TRAF3 AEROBIC GLYCOLYSIS AUGMENTED%WIKIPATHWAYS_20260810%WP4628%HOMO SAPIENS Aerobic glycolysis augmented HEL-S-162eP HEL-S-87p HEL-S-133P ENO1 HEL-S-49 HEL-S-68p HEL-S-30 PGAM2 GPT PFKM TOLL LIKE RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP75%HOMO SAPIENS Toll like receptor signaling IL12A MAP3K8 NFKB1 IFNAR2 IFNA13 IFNA14 TICAM2 IFNA16 IFNA17 STAT1 TICAM1 IFNAR1 IFNA10 LY96 IRAK1 RIPK1 CD14 FADD IFNA21 NFKBIA CXCL11 TAB3 MYD88 IFNA5 IFNA4 IFNA7 CD40 CXCL9 CXCL8 IFNA6 IFNA1 IFNA2 IFNA8 CASP8 LBP IRAK4 FOS opn TIRAP TLR1 IRF3 TRAF3 IL1B TRAF6 TLR9 IRF7 TLR8 TLR7 MAP2K3 TLR5 MAP2K1 TLR4 MAP2K2 TLR3 TNF RELA MAPK9 CCL5 CCL4 CCL3 MAPK1 IFNB1 MAPK12 RAC1 MAPK13 MAPK10 MAP2K6 MAP3K7IP1 JUN MAPK11 MAPK3 MAPK14 AKT3 IKBKB MAPK8 IKBKG IKBKE MAP3K7 IL6 MAP2K4 CHUK CD80 NFKBIB TBK1 IL12B TLR4 SIGNALING AND TOLERANCE%WIKIPATHWAYS_20260810%WP3851%HOMO SAPIENS TLR4 signaling and tolerance NFKB1 TRAF6 IRF7 TLR4 TNF TICAM1 INPP5D IFNB1 IRAK1 RIPK1 MAP3K7IP1 NFKBIA MYD88 CXCL8 IKBKB IKBKG IKBKE MAP3K7 TRAM1 IL6 IRAK3 IRAK4 CHUK TIRAP TBK1 IRF3 TRAF3 TH17 CELL DIFFERENTIATION PATHWAY%WIKIPATHWAYS_20260810%WP5130%HOMO SAPIENS Th17 cell differentiation pathway LAT NFKB1 TGFBR1 PER1 TBX21 IL21R TYK2 CRY1 STAT1 STAT3 IL4 JAK1 IFNGR1 NFKBIA IL27 RORC AHR IL27RA IL2 SOCS3 PLCG1 IL17F FOS FOXP3 IL1B IL2RA NR1D1 MTOR IFNG MAPK1 RXRA JUN HIF1A RORA RUNX1 MAPK14 IL22 IL-21 IL6R SMAD2 IL23R CD3G IKBKB CD3E PPP3CA CD3D IRF4 MAPK8 IL17A NFIL3 GATA3 ZAP70 HLA-DMA IL23A NFATC1 LCK IL6 TGFB1 RARA PRKCQ 7Q11 23 DISTAL COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5401%HOMO SAPIENS 7q11 23 distal copy number variation MDH2 HEL-S-102 SRRM3 PTPMT1 LMNA TMEM120B RAF1 YWHAG RHBDD2 TMEM120A SSC4D SFN STYXL1 HEL163 POR KIF1C DAPK2 ZP3 ZP2 PHOSPHOINOSITIDE 3 KINASE PI3K FAMILY%WIKIPATHWAYS_20260810%WP5472%HOMO SAPIENS Phosphoinositide 3 kinase PI3K family PIK3R1 PIK3R5 PIK3R4 PIK3C2G PIK3CD PIK3R3 PIK3R2 PIK3C2B CELL DIFFERENTIATION INDEX%WIKIPATHWAYS_20260810%WP2029%HOMO SAPIENS Cell differentiation index TLX2 TLX3 LEFTY2 LEFTY1 HDAC5 STAT3 TLX1 SOMITOGENESIS IN THE CONTEXT OF SPONDYLOCOSTAL DYSOSTOSIS%WIKIPATHWAYS_20260810%WP4785%HOMO SAPIENS Somitogenesis in the context of spondylocostal dysostosis MESP2 DLL3 HES7 LFNG EPHA4 NOTCH1 RIPPLY2 TBX6 INFLUENCE OF LAMINOPATHIES ON WNT SIGNALING%WIKIPATHWAYS_20260810%WP4844%HOMO SAPIENS Influence of laminopathies on Wnt signaling LEF1 CEBPD APC CSNK1A1L EMD WNT10B TCF7L2 TCF7L1 HMGA2 RUNX2 TOR1AIP1 CSNK1A1 DICER1 CDK6 CEBPA CEBPB GSK3B HES1 HES5 ICMT ZMPSTE24 CCND1 TARBP2 FNTA LMNA AGO2 PPARG AXIN1 opn SLC2A4 KENNEDY PATHWAY FROM SPHINGOLIPIDS%WIKIPATHWAYS_20260810%WP3933%HOMO SAPIENS Kennedy pathway from sphingolipids PISD SGPL1 CEPT1 PTDSS2 PTDSS1 PEMT CHPT1 PCYT2 CHKB PCYT1B CHKA NITRIC OXIDE METABOLISM IN CYSTIC FIBROSIS%WIKIPATHWAYS_20260810%WP4947%HOMO SAPIENS Nitric oxide metabolism in cystic fibrosis PRMT6 HEL-S-277 PRMT2 PRMT7 PRMT3 NOS2 PRMT1 CARM1 CALCIUM REGULATION IN CARDIAC CELLS%WIKIPATHWAYS_20260810%WP536%HOMO SAPIENS Calcium regulation in cardiac cells GNGT1 PRKD1 CALM1 RYR3 CHRM1 DKFZp686L0365 ADRB3 FKBP1A CAMK2A ADRB1 CHRM4 ADRB2 GNB2 CHRM5 GNB1 GNB4 ITPR2 CACNA1C ATP2A2 PRKAR1A CACNA1S GJB2 GNG3 GNG2 GNG5 GNG4 ORAI1 GNG7 GNG8 CACNB1 HEL-S-99n CAMK4 CACNB3 CHRM3 ADRA1B ADRA1A ADRA1D CHRM2 HEL2 GNAI3 GNAI1 GJA1 GJB1 GJA3 PKIA GJA5 GJA4 GJA8 GJA9 ATP1B3 ATP1B2 RGS16 STIM2 GJC1 GJC2 PRKAR1B GJB4 RYR1 GJB3 PRKCB GJB5 PLCB3 GJD2 CASQ2 CASQ1 HEL-S-93 ATP1A4 KCNB1 PRKCH PRKCE PRKCQ CAMK2G YWHAQ HEL-S-1 PRKCZ GNB3 RYR2 SLC8A1 ATP2B3 ATP2B2 YWHAG KCNJ5 ATP2B1 RGS2 GNB5 RGS14 GNAS ATP1B1 ADCY3 ADCY1 FXYD2 ADCY8 GNAZ ADCY6 ADCY5 GNA11 RGS4 ADCY9 RGS5 GNAO1 RGS1 RGS6 SFN ANXA6 GRK5 GRK4 PRKCA PKIB GJB6 PKIG RGS18 RGS17 RGS20 CAMK2D RGS11 KCNJ3 CAMK1 PLN CACNA1B CACNA1A GNG12 GNG11 GNG13 RGS10 DOPAMINE METABOLISM%WIKIPATHWAYS_20260810%WP2436%HOMO SAPIENS Dopamine metabolism NQO1 MAOA PRKACG HEL-S-44 DDC TYR PPP2CA TH BARDET BIEDL SYNDROME%WIKIPATHWAYS_20260810%WP5234%HOMO SAPIENS Bardet Biedl syndrome NEK1 PKD1 CFAP418 CFAP410 BBS4 CEP290 PKHD1 TRAF3IP1 NEK8 DCDC2 INVS NPHP3 FLCN SUFU IQCB1 CEP164 CNGA1 KIF7 RAB23 OCRL RP2 CNGB1 EFHC1 PKD1L1 PCARE DYNC2H1 DYNC2I2 IFT172 IFT140 IFT52 DYNLT2B CEP41 IFT80 TMEM107 WDR35 TRIM32 DYNC2LI1 BBS9 BBS7 IFT43 IFT81 IFT57 BBIP1 IFT27 BBS5 LZTFL1 BBS10 EVC BBS12 TMEM216 WDPCP CEP104 ARL6 ARL3 ZIC2 IFT74 ARL13B TMEM67 INPP5E SMO CRX EVC2 BBS2 USP9X MKS1 GPR161 BBS1 SCLT1 SCAPER FUZ EFHC2 GLI3 PDE6D PTCH1 TTC8 SDCCAG8 CLUAP1 SELENIUM METABOLISM AND SELENOPROTEINS%WIKIPATHWAYS_20260810%WP28%HOMO SAPIENS Selenium metabolism and selenoproteins SELENON NFKB1 SARS1 SELENOM RPL30 SARS2 SELENOW SELENOV SELENOT MSRB1 SELS GPX2 SELENOP GPX1 RELA GPX4 GPX3 GPX6 HEL-S-134P JUN NFE2L2 SP1 CTH SP3 FABP1 POU2F1 TXNRD2 SELENOK CREM SELENOF SELENOI SELENOH SEPHS1 SEPHS2 PSTK FOS EEFSEC DIO1 TRNAU1AP SELENOO SEPSECS METHIONINE METABOLISM LEADING TO SULFUR AMINO ACIDS AND RELATED DISORDERS%WIKIPATHWAYS_20260810%WP4292%HOMO SAPIENS Methionine metabolism leading to sulfur amino acids and related disorders HEL-S-61p HEL-S-182mP CTH CDO1 MTR ADK CBS pcap MAT1A PILOCYTIC ASTROCYTOMA%WIKIPATHWAYS_20260810%WP2253%HOMO SAPIENS Pilocytic astrocytoma NF1 NRAS RAF1 BRAF HRAS GRB2 PTPN11 SOS1 DISORDERS OF BILE ACID SYNTHESIS AND BILIARY TRANSPORT%WIKIPATHWAYS_20260810%WP5176%HOMO SAPIENS Disorders of bile acid synthesis and biliary transport ABCC2 AKR1C4 CYP8B1 SLC51A AMACR SLC51B SLC27A5 SLC27A2 HSD3B7 SLC10A2 FABP6 ABCB11 CYP7A1 AKR1D1 CYP7B1 ABCB4 CYP27A1 BAAT ABCD3 HSD17B4 ABCC3 ABCB1 ATP8B1 SLCO1B1 STING PATHWAY IN KAWASAKI LIKE DISEASE AND COVID 19%WIKIPATHWAYS_20260810%WP4961%HOMO SAPIENS STING pathway in Kawasaki like disease and COVID 19 IL1B NFKB1 NLRP3 NFKBIE FCGR2A IKBKB RELA MITA IKBKG IKBKE IFNB1 REL NLRX1 CGAS F3 CHUK TBK1 IRF3 GSDMD NFKBIA SELENIUM MICRONUTRIENT NETWORK%WIKIPATHWAYS_20260810%WP15%HOMO SAPIENS Selenium micronutrient network SELENON APOB LDLR NFKB1 SELENOM SELENOW TXN SELENOV SELENOT MSRB1 SELS GPX2 SERPINA3 HEL-S-97n GPX1 GPX4 SAA4 GPX3 PRDX3 KMO PRDX5 GPX6 SAA1 KYNU FGA SAA2 HEL-S-302 HEL-75 PLAT PLG HEL-S-78p F7 CBS NFKB2 HEL-S-44 CTH CRP PTGS2 ALB MTR IL1B FLAD1 PTGS1 TNF SELENOP RELA ALOX5 IFNG CCL2 ALOX15B HEL-S-2a ALOX5AP INS MPO TXNRD2 SELENOK F2 SELENOF ABCA1 SCARB1 SELENOI IL6 SELENOH XDH SEPHS2 INSR HBB DIO1 HBA2 SELENOO PCSK9 MEDIATED LDL RECEPTOR DEGRADATION%WIKIPATHWAYS_20260810%WP2846%HOMO SAPIENS PCSK9 mediated LDL receptor degradation LDLR PCSK9 HEROIN METABOLISM%WIKIPATHWAYS_20260810%WP2645%HOMO SAPIENS Heroin metabolism CES2 CES1 BCHE ISOGLOBO SERIES SPHINGOLIPIDS%WIKIPATHWAYS_20260810%WP5311%HOMO SAPIENS Isoglobo series sphingolipids B3GALT5 KCNQ2 RELATED EPILEPSIES%WIKIPATHWAYS_20260810%WP5360%HOMO SAPIENS KCNQ2 related epilepsies BDKRB2 AGTR1 SCN1B CALM1 AKAP5 CSNK2A1 STX1A BACE1 P2RY1 PPP3CC CHRM1 PPP1R10 PLCG2 KCNQ2 KCNQ3 PRKCA MITOCHONDRIAL FISSION AND FUSION%WIKIPATHWAYS_20260810%WP4318%HOMO SAPIENS Mitochondrial fission and fusion SH3GL2 BNIP3 BCL2L1 MTFP1 MIB1 FIS1 BAX OPA1 MFN1 MFN2 STEROID HORMONE PRECURSOR BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5277%HOMO SAPIENS Steroid hormone precursor biosynthesis AKR1D1 HSD3B2 SRD5A2 HSD3B1 CYP17A1 CYP21A2 CYP11A1 AKR1C1 SIGNAL TRANSDUCTION THROUGH IL1R%WIKIPATHWAYS_20260810%WP4496%HOMO SAPIENS Signal transduction through IL1R IL1B NFKB1 TRAF6 MAP2K3 IL1R1 MAP3K14 TNF RELA IFNB1 IRAK1 IRAK2 MAP2K6 MAP3K7IP1 JUN IL1RN NFKBIA MAPK14 MYD88 IL1A IFNA1 IKBKB MAPK8 MAP3K7 IL6 TGFB1 IRAK3 ECSIT MAP3K1 CHUK INHIBITORS OF METABOLISM IN MELANOMA THERAPY%WIKIPATHWAYS_20260810%WP5609%HOMO SAPIENS Inhibitors of metabolism in melanoma therapy DLAT PDHA1 HEL-S-133P MAP2K1 MAP2K2 HEL-S-281 GPX4 DLD MTOR MAPK1 RAF1 SLC16A3 HEL-75 MAPK3 PFKFB2 GLS RPTOR RPS6KA2 RPS6KA1 ARAF ACSS1 CPT1A PKLR HEL-S-304 MLST8 PPARGC1A BRAF NAMPT HEL-S-30 2Q21 1 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5223%HOMO SAPIENS 2q21 1 copy number variation syndrome APC STAT3 CDC27 ARHA RAC1 AMER3 STMN2 MZT2A FAM168B CCDC74A POTEE TUBA2 GPR148 CCDC42 ARHGEF4 SREBF AND MIR33 IN CHOLESTEROL AND LIPID HOMEOSTASIS%WIKIPATHWAYS_20260810%WP2011%HOMO SAPIENS SREBF and miR33 in cholesterol and lipid homeostasis HMGCS1 LDLR SREBF2 PRKAA1 NR1H3 FASN SIRT6 MTOR SIRT1 ABCA1 PPARGC1A NR1C1 SCD HMGCR MED15 AXON GUIDANCE%WIKIPATHWAYS_20260810%WP5289%HOMO SAPIENS Axon guidance PRKCZ HRAS CDC42 CXCR4 WNT4 FZD3 DCC MYL12B ITGB1 SEMA5B ROBO3 DPYSL5 gdf7 UNC5D SEMA7A EFNB1 ABLIM3 SLIT1 SLIT3 EFNA1 EPHB1 LRIG2 SRGAP2 RRAS NTNG2 L1CAM NGL1 FES NRP1 ROBO2 RHOD SLIT2 PARD6A CXCL12 SRC HEL-S-15 NTN3 MAPK1 PARD3 RAF1 FYN RAC1 TRPC1 ARHGEF12 PRKCA GNAI1 SHH RGMA ROCK1 CDK5 RYK GSK3B NCK1 ROBO1 HEL-S-28 EPHA2 PLXNA1 SEMA3A PTCH1 BOC PDPK1 MBDNF AND PROBDNF REGULATION OF GABA NEUROTRANSMISSION%WIKIPATHWAYS_20260810%WP4829%HOMO SAPIENS mBDNF and proBDNF regulation of GABA neurotransmission GABRB3 GABRB2 GABRB1 AP2A1 AP2A2 GABRE PIK3R3 GABRQ STAT3 GABRA2 GABRP PIK3R2 PIK3R1 SLC12A5 GABRA6 GABRA5 GABRA4 GABRA3 PTEN GABRG3 GABRG1 ROCK1 NTRK2 CREM ARHA SHC1 PLCG1 CREB1 NGFR BDNF EDA SIGNALING IN HAIR FOLLICLE DEVELOPMENT%WIKIPATHWAYS_20260810%WP3930%HOMO SAPIENS EDA signaling in hair follicle development SHH DKK1 SOSTDC1 BMP1 TNLG7C EDAR PTCH1 DKK4 WNT3 EDARADD LTB RELB EFFECT OF DASATINIB ON THE BCR ABL SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP5493%HOMO SAPIENS Effect of dasatinib on the BCR ABL signaling pathway BCR HSPB2 SPAG1 MAP3K2 SRC HRAS BCLAF1 VAV1 SOS1 PIK3R1 INPP5D NRAS MAPK1 RAF1 MAPK11 MAPK3 SHC4 BCL9 MAPK14 SHC2 SHC3 RPS6KA1 MEF2C ARAF AKT3 CRKL EIF4B HEL-S-102 ATF2 CBL DOK1 SHC1 CRK PXN BRAF BCL2 GRB2 GAB2 DOPAMINERGIC NEUROGENESIS%WIKIPATHWAYS_20260810%WP2855%HOMO SAPIENS Dopaminergic neurogenesis SOX2 SLC18A2 SLC6A3 RET STAT3 GBX2 EN1 MSX1 NKX6-1 CDKN1C TH SHH FOXA2 DDC FGF8 ASCL1 WNT1 NEUROG2 PITX3 EN2 LMX1A NEUROD1 TGFB1 LMX1B HEL-S-53e OTX2 NKX2-2 ANK2 PATHWAY IN EPILEPSY DEVELOPMENT%WIKIPATHWAYS_20260810%WP5557%HOMO SAPIENS ANK2 pathway in epilepsy development SPTAN1 CSNK2A2 CSNK2A1 SNAP25 CSNK2B L1CAM ATF4 SEMA3A SCN5A SPTBN4 DDIT3 BRSK1 PRRT2 ANK2 KCNQ2 SCN2A EIF2A ACETAMINOPHEN IN ANALGESIA AND ANTIPYRESIS%WIKIPATHWAYS_20260810%WP5444%HOMO SAPIENS Acetaminophen in analgesia and antipyresis HTR1A PTGS1 KCNQ2 FAAH KCNQ3 TRPA1 PTGS2 CACNA1H TRPV1 INHIBITION OF EXOSOME BIOGENESIS AND SECRETION BY MANUMYCIN A IN CRPC CELLS%WIKIPATHWAYS_20260810%WP4301%HOMO SAPIENS Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells RAB5B RAB5C HGS HNRNPH1 HRAS ARAF RAB27A RRAS RAB5A NRAS MAPK1 RAF1 BRAF PDCD6IP RRAS2 MAPK3 CORI CYCLE%WIKIPATHWAYS_20260810%WP1946%HOMO SAPIENS Cori cycle HEL-S-162eP HEL-S-87p HEL-S-133P SLC2A2 HEL-S-49 HEL-S-68p PGAM1 PFKP GPT SLC2A4 INS CYCLIN DEPENDENT KINASE 4 6 INHIBITORS IN BREAST CANCER%WIKIPATHWAYS_20260810%WP5497%HOMO SAPIENS Cyclin dependent kinase 4 6 inhibitors in breast cancer CDKN1B HRAS PIK3CD PIK3R3 PIK3R2 PIK3R1 MTOR NRAS CCNE1 MAPK1 PIK3R5 RAF1 PIK3R4 PIK3C2G MAPK3 IRS1 INS PIK3C2B RPTOR CDK6 CDK4 IGF1R AKT3 CDK2 EGFR CCND1 ERBB2 CDKN1A WNT SIGNALING%WIKIPATHWAYS_20260810%WP428%HOMO SAPIENS Wnt signaling CSNK2A3 CSNK2A2 DKK2 DKK4 SFRP4 CSNK2B TCF7L1 INVS DAAM1 CSNK1A1 ROR1 CAMK2A CCND1 CER1 WNT2B SOST SFRP5 KREMEN1 NOTUM WNT1 CSNK2A1 MYC PORCN WNT3A FZD10 CHD8 WNT7B PRKCB hCG_2014051 PLCB3 FRAT1 PLCB4 PPP3CC ARHA DKK1 SENP2 CXXC4 PLCB1 NFATC3 PLCB2 WNT5B NFATC1 NFATC4 AXIN1 WNT16 CTBP2 CAMK2G LEF1 LRP5 NKD1 LRP6 NKD2 APC DVL1 DVL2 DVL3 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A FZD3 FZD2 FZD7 FZD9 WNT7A FOSL1 CTNNBIP1 DAAM2 VANGL1 PRICKLE2 GPC4 CCND3 SOX17 CCND2 ROR2 CTBP1 SFRP1 NLK MAPK9 RAC1 WIF1 JUN PRKCA FZD5 FZD8 RYK GSK3B CAMK2D ROCK2 PPP3CA MAPK8 MAP3K7 PPP3R1 PPP3R2 NFATC2 FRAT2 BETA GLOBIN GENE EXPRESSION REGULATION%WIKIPATHWAYS_20260810%WP5606%HOMO SAPIENS Beta globin gene expression regulation CHD3 GATAD2B MYB tal-1 NR2C2 MTA2 ZFPM1 ZBTB7A HDAC2 KDM1A LMO2 HDAC1 PPARGC1A HBG2 HBG1 KLF1 HBE1 HBB HBD GATA1 LDB1 BMP2 WNT4 FOXO1 PATHWAY IN PRIMARY ENDOMETRIAL STROMAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP3876%HOMO SAPIENS BMP2 WNT4 FOXO1 pathway in primary endometrial stromal cell differentiation DCN BCL2L11 DKK1 SMAD1 SMAD9 LEFTY2 BMP2 DKFZp781O1323 SFRP1 FOXO1 WNT4 SST CANNABINOID RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP3869%HOMO SAPIENS Cannabinoid receptor signaling ADCY1 NAPEPLD DAGLB CYP2C19 MAPK9 CYP2C9 MAPK1 MAPK12 DAGLA MAPK13 MAPK10 MAPK11 MAPK3 ADORA2A MAPK14 CYP1A1 CNR2 CYP3A4 AHR CNR1 PRKAR1B MAPK8 PRKACG FAAH PRKAR1A CELL LINEAGE MAP FOR NEURONAL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP5417%HOMO SAPIENS Cell lineage map for neuronal differentiation PAX3 MIXL1 SLC18A3 CLDN11 UNC13A SYP NLGN1 TWIST2 FOXA2 S100B CASK NEFL GATA4 TBXT SOX9 MSX2 ZFP42 OLIG2 SOX10 ERAS TWIST1 NOTCH1 MBP MSX1 AQP4 FGF4 GLS GFAP SNAI1 HTR5A TPH1 ADRA2C FOXD3 ADRA2B SLC1A3 ADRA2A BMP4 MAP2 TPM1 ChAT NODAL HOMER2 POU5F1 HTR1A SLC6A5 SLC6A9 LEF1 SLC6A2 SHANK3 FEV AP2A1 SLC6A3 AP2A2 SHANK1 GPHN CNP SNAP25 MOG GABBR2 GABBR1 HES3 GAD1 ACHE ESRRB GAD2 TNC ITGB1 PECAM1 CSPG4 HES1 CDH2 HES5 KLF4 GRIN1 PIG59 SLC1A2 SNAI2 SOX2 GRIN2B CD34 SOX17 RIMS2 BSN RBFOX3 FBXO15 HOMER1 TBR1 GATA6 LIN7A CACNG2 FUT4 CD24 PCLO ERC1 DPPA3 DLG2 DPPA2 GLRA1 GLRA2 GLRA3 GLRB RIMBP2 TH NEF3 HOMER3 HNF4A KCNJ6 ITGA6 ROBO1 LHX1 DLG4 NGFR LMX1B SLC17A6 SLC17A7 TYPE II INTERFERON SIGNALING%WIKIPATHWAYS_20260810%WP619%HOMO SAPIENS Type II interferon signaling IL1B HLA-B EIF2AK2 PSMB9 NOS2 SPI1 STAT1 IRF-1 IRF9 IFNB1 CYBB IFNG SOCS1 STAT2 JAK1 IFNGR1 IFI6 IFNGR2 IFIT2 GBP1 H4C9 PTPN11 CXCL9 IFNA2 IRF4 SOCS3 MHC2TA ISG15 IRF2 IRF8 GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260810%WP661%HOMO SAPIENS Glucose homeostasis INS HALLMARK OF CANCER SUSTAINING PROLIFERATIVE SIGNALING%WIKIPATHWAYS_20260810%WP5475%HOMO SAPIENS Hallmark of cancer sustaining proliferative signaling NFKB1 LEF1 LRP5 HRAS LRP6 APC GAREM2 FGFR2 ULK2 STAT3 SOS1 SOS2 PTEN NR1C2 PDGFRA AKT1S1 CSNK1A1 NFKBIA FLT1 NFKBIE IGF1R NTRK2 EGFR CCND1 SHC1 MLST8 RETN REL KSR1 FOS FGFR1 FOXO1 SALL4 SRC MAP2K1 RHEB MAP2K2 PIK3CD TSC2 TSC1 RELA KDR MTOR MAPK1 RAF1 FLT3 CSF1R FLT4 RUNX1T1 JUN MAPK3 PYGO1 PML DEPTOR JUP BCL9 TTI1 RPTOR ZBTB16 WNT1 AKT3 IL6R GSK3B MDM2 MYC IKBKB TCF3 IKBKG EPHA2 NTRK1 BRAF IL6 NGFR AXIN2 KIT INSR CHUK RARA GRB2 FGFR4 FGFR3 CDKN1A EFFECT OF PROGERIN ON GENES INVOLVED IN PROGERIA%WIKIPATHWAYS_20260810%WP4320%HOMO SAPIENS Effect of progerin on genes involved in progeria RB1 CHD3 RBBP4 LEF1 MTA2 H3C15 MBD3 CHD4 RBBP7 HDAC2 KDM1A H3C8 HDAC1 SUV39H1 CBX3 MBD2 H3F3B CBX1 MTA3 HEL25 WARBURG EFFECT MODULATED BY DEUBIQUITINATING ENZYMES AND THEIR SUBSTRATES%WIKIPATHWAYS_20260810%WP5216%HOMO SAPIENS Warburg effect modulated by deubiquitinating enzymes and their substrates USP37 USP44 G6PC1 OTUD7B USP28 USP19 OTUD6B HEL-S-133P HEL-S-68p MYC U2AF2 MTOR KDR SIRT7 VEGFA VHL PGAM1 HIF1A FOXO1 HK2 FBP1 OTUB2 PEROXISOMAL BETA OXIDATION OF TETRACOSANOYL COA%WIKIPATHWAYS_20260810%WP1941%HOMO SAPIENS Peroxisomal beta oxidation of tetracosanoyl CoA ACOX1 HSD17B4 LEPTIN SIGNALING%WIKIPATHWAYS_20260810%WP2034%HOMO SAPIENS Leptin signaling NFKB1 HRAS CISH CDC42 STAT1 STAT3 SOS1 BAD PTEN JAK1 GSK3A SP1 PRKAA2 SOCS7 LEPR NCOA1 SHC1 ERBB2 ACACA PTPN1 SOCS3 PLCG2 REL PLCG1 CREB1 FOXO1 CFL2 SRC MAP2K1 PRKAA1 MAP2K2 RELA PIK3R2 PIK3R1 SOCS2 MTOR EIF4EBP1 MAPK1 RAF1 FYN RAC1 EIF4E MAPK3 IRS1 ACACB PTPN11 MAPK14 ROCK1 RPS6KA1 KPNA4 KHDRBS1 GSK3B ROCK2 LEP RPS6 RPS6KB1 IKBKB MAPK8 ARHA IKBKG STAT5B PDE3B SH2B1 CHUK GRB2 IL26 SIGNALING%WIKIPATHWAYS_20260810%WP5347%HOMO SAPIENS IL26 signaling IL1B ATP6V0D2 TYK2 MMP9 TNF STAT1 STAT3 IL20RA COX2 RELA MAPK9 CASP3 ACTA2 MAPK1 DDIT3 JAK1 BAX IL10 JUN MAPK3 DEFB4B NFKBIA IL33 MAPK14 IL26 MPO TNFSF11 DCSTAMP RORC SMAD2 CXCL8 CSF2 MAPK8 IL17A EPHA3 SOCS3 CCL20 NFATC1 IL6 CTSK IL10RB 2Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5221%HOMO SAPIENS 2q11 2 copy number variation syndrome CIAO2B COL2A1 CIAO2A MAPK1 MAPK3 ZP2 COX11 ANKRD39 PARL CIAO1 ITPRIPL1 TMEM127 CNNM3 CNNM4 FER1L5 STARD7 ARHA ERBB2 DUSP2 SEMA4C ADRA2B ARID5A ASTL NEURL3 KANSL3 ANKRD23 PLXNB2 MMS19 SNRNP200 MALATE ASPARTATE SHUTTLE%WIKIPATHWAYS_20260810%WP4315%HOMO SAPIENS Malate aspartate shuttle SLC1A3 GOT2 HEL-S-32 SLC25A11 VISUAL CYCLE%WIKIPATHWAYS_20260810%WP5534%HOMO SAPIENS Visual cycle RDH8 RHO RLBP1 RPE65 OPN1LW RBP1 OPN1SW RDH5 RDH12 LRAT RDH10 OPN1MW ABCA4 RBP3 RDH11 REGUCALCIN IN PROXIMAL TUBULE EPITHELIAL KIDNEY CELLS%WIKIPATHWAYS_20260810%WP4838%HOMO SAPIENS Regucalcin in proximal tubule epithelial kidney cells TGFBR1 TNFRSF1A APAF1 BAK1 CASP3 MTOR ACTA2 MAPK1 RAF1 BAX MAP3K5 PTH TNFSF11 CALCA SMAD2 CASP8 FFAR3 PDE1B SMAD4 BRAF TGFB1 PPP3R1 SEC16B CASP9 HEL-S-41 TRPV5 NCRNAS IN WNT SIGNALING IN HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260810%WP4336%HOMO SAPIENS ncRNAs in Wnt signaling in hepatocellular carcinoma CTBP2 LEF1 LRP5 CSNK2A3 CSNK2A2 NKD1 LRP6 DKK2 NKD2 APC DKK4 SFRP4 DVL1 CSNK2B DVL2 DVL3 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A FZD3 FZD2 TCF7L1 FZD7 FZD9 WNT7A FOSL1 CSNK1A1 ROR1 KLF4 CCND1 ELAVL1 SOX7 CTNNBIP1 CCND3 SOX17 CCND2 ROR2 CSNK1A1L CTBP1 SFRP1 NLK EZH2 CER1 WIF1 WNT2B SOST JUN SFRP5 FZD5 KREMEN1 FZD8 NOTUM WNT1 RYK GSK3B CSNK2A1 MYC PORCN WNT3A CHD8 FZD10 WNT7B hCG_2014051 FRAT1 SENP2 DKK1 CXXC4 WNT5B AXIN1 WNT16 FRAT2 MTDH TRYPTOPHAN METABOLISM%WIKIPATHWAYS_20260810%WP465%HOMO SAPIENS Tryptophan metabolism AOC1 KYAT3 KYAT1 ALDH8A1 TPH2 IL4I1 GOT2 AADAT STAT1 HAAO KMO DLD TDO2 KYNU AFMID IDO2 IDO1 ACAT1 AANAT MAOA CYP1A1 ASMT DDC AHR TPH1 ECHS1 AOX1 GCDH INMT ALDH2 PYRIMIDINE METABOLISM AND RELATED DISEASES%WIKIPATHWAYS_20260810%WP4225%HOMO SAPIENS Pyrimidine metabolism and related diseases AGXT2 DPYD UMPS ABAT HEL74 CAD RRM2B DPYS DHODH OTC TYMP TYMS GLS2 RRM1 RRM2 NT5C3A NAD BIOSYNTHETIC PATHWAYS%WIKIPATHWAYS_20260810%WP3645%HOMO SAPIENS NAD biosynthetic pathways TNKS2 TNKS NAPRT PARP4 PARP2 BST1 PARP1 NADSYN1 HEL-S-90n SIRT4 SIRT5 SIRT6 TDO2 SIRT7 SIRT1 SIRT2 IDO1 SIRT3 NMNAT1 NAMPT SICKLE CELL DISEASE%WIKIPATHWAYS_20260810%WP5604%HOMO SAPIENS Sickle cell disease IL1B TLR4 IL18 HBB HBA2 HAIR FOLLICLE DEVELOPMENT ORGANOGENESIS STAGE 2 OF 3%WIKIPATHWAYS_20260810%WP2839%HOMO SAPIENS Hair follicle development organogenesis stage 2 of 3 NFKB1 LEF1 LRP5 FOXI3 CCND2 FGFR2 GTPBP4 FZD1 TNLG7C EDAR PDGFRA PDGFA RUNX2 ITGB1 SHH GJB6 SNAI1 MYC SMO CCND1 INHBA TP63 BMP4 PTCH1 LAMA5 NCAM1 MRNA VACCINE ACTIVATION OF DENDRITIC CELL AND INDUCTION OF IFN 1%WIKIPATHWAYS_20260810%WP5187%HOMO SAPIENS mRNA vaccine activation of dendritic cell and induction of IFN 1 IFIH1 IRF7 TLR8 TLR7 MR1 MAVS TNFRSF11A TLR3 RIGI IRF3 NAD METABOLISM IN ONCOGENE INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ASSOCIATED SENESCENCE%WIKIPATHWAYS_20260810%WP5046%HOMO SAPIENS NAD metabolism in oncogene induced senescence and mitochondrial dysfunction associated senescence IL1B MDH2 GOT2 PRKAA1 HMGA1 PARP1 CCL27 RELA SIRT5 NMNAT2 SIRT1 SIRT2 ELAVL1 SIRT3 IL6 HEL-S-32 NAMPT SLC2A4 OMEGA 9 FATTY ACID SYNTHESIS%WIKIPATHWAYS_20260810%WP4724%HOMO SAPIENS Omega 9 fatty acid synthesis ELOVL2 ELOVL1 SCD5 ELOVL3 ELOVL6 ACSL3 FADS2 ACSL1 FASN FACL4 FADS1 SCD ELOVL5 RETINOBLASTOMA GENE IN CANCER%WIKIPATHWAYS_20260810%WP2446%HOMO SAPIENS Retinoblastoma gene in cancer CCDC6 PRMT2 PRIM1 SKP2 POLD3 E2F2 RBBP7 SMC2 TTK NPAT HLTF SAP30 CCNB1 PLK4 POLA1 CCNA2 RRM1 POLE2 RRM2 HMGB1 TFDP1 TFDP2 H2AZ1 CCND1 MCM7 CDC45 ORC1L HDAC1 CDT1 PCNA TYMS MCM3 MCM6 BARD1 FAF1 DHFR RB1 CDKN1B CCND3 SMC3 RFC3 RFC4 CHEK1 RBP1 RPA1 MSH6 E2F3 RPA3 SMC1A CCNE2 CCNE1 PRKDC FANCG RAF1 CCNB2 MAPK13 CDC25B SUV39H1 SIN3A CDC2 RBBP4 CDK6 ZNF655 CDK4 CDK2 MDM2 MYC POLE WEE1 HMGB2 TOP2A CDKN1A RNA POLYMERASE II TRANSCRIPTION THE PREINITIATION COMPLEX%WIKIPATHWAYS_20260810%WP5563%HOMO SAPIENS RNA polymerase II transcription the preinitiation complex POLR2A POLR2B POLR2D POLR2G POLR2H POLR2I POLR2J POLR2K MED1 POLR2L MED19 MED16 MED18 MED17 NELFA MED12 NELFE MED11 MED14 MED13 MED10 MED8 MED4 NELFB GTF2F1 MED26 MED6 MED28 MED22 MED15 MED25 MED24 THRA MED21 GTF2A1 MED30 MED31 MED23 POLR2M TAF10 TAF8 MED27 TAF11 TRFP CRSP9 TAF4 IXL TAF3 TAF1 CDK8 CCNC CTDP1 MED9 POLR2C NELFCD GTF2B TAF9 GTF2E2 POLR2F TBP TAF12 TAF13 TAF7 TAF6 TAF5 DISORDERS IN KETOLYSIS%WIKIPATHWAYS_20260810%WP5195%HOMO SAPIENS Disorders in ketolysis HMGCS1 ACAT2 BDH1 OXCT1 ACAT1 COMPLEMENT SYSTEM IN NEURONAL DEVELOPMENT AND PLASTICITY%WIKIPATHWAYS_20260810%WP5090%HOMO SAPIENS Complement system in neuronal development and plasticity CASP10 PRKCZ APAF1 BAK1 FCN1 HEL-S-62p COLEC11 BAX ITGB3 ITGAV CAP1 FCN2 C4BPA CFD CFB ATP10A CD59 CX3CL1 PATJ FCN3 C4BPB CASP8 DLGAP5 ATP11C PLSCR3 PLSCR4 MBL2 LLGL2 CRB2 COLEC12 CRB1 COLEC10 DIABLO TYRO3 PARD6G DEDD ATP8B3 CASP9 PALS1 PARD6A MARK1 SCRIB MFGE8 PARD6B CASP3 MERTK IFNG ITGAM PARD3 C1QB C1QA AXL C1S ATP8B2 CFP MBP C8A C6 C8G C7 C9 ITGAX MASP2 CX3CR1 C4A MASP1 HTRA2 CD55 C1QC SERPING1 ATP11A CR1 PLSCR1 PROS1 CLU C3AR1 CR2 PRKCI CD46 CFH C4B_2 CFI C5AR2 C5AR1 TGFB1 TNFSF6 CYCS VTN ATP8B1 OXIDATIVE PHOSPHORYLATION%WIKIPATHWAYS_20260810%WP623%HOMO SAPIENS Oxidative phosphorylation ATP5G1 HEL-S-271 ND1 ND3 ND2 ND5 ND4 ND6 NDUFS8 ATP6 NDUFS3 COXFA4 ATP5MC2 ATP5J ATP5MC3 ATP5H HEL-S-123m ATP5MG ATP5MF ATP5ME DMAC2L NDUFA9 ATP5PB ND4L ATP5F1D ATP5F1E ATP5PO NDUFB10 ATP6AP2 NDUFA11 NDUFA10 COXFA4L2 NDUFV3 NDUFV2 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB2 NDUFB1 NDUFA7 NDUFA6 NDUFA5 NDUFA3 NDUFA2 NDUFAB1 CORTICOTROPIN RELEASING HORMONE SIGNALING%WIKIPATHWAYS_20260810%WP2355%HOMO SAPIENS Corticotropin releasing hormone signaling CASP12 NFKB1 GNB3 ECE1 CACNA1H DKFZp686L0365 FOSL1 NFKBIA SP1 PRKAA2 CXCL8 CAMK2A GNB2 GNB5 GNB1 GNAS ACACA IL2 PLCG2 HSD3B2 PLCG1 HSD3B1 CREB1 POMC FOS STAR CASP9 CYP21A2 CRHBP CYP11A1 KRT1 IVL KRT14 GNAZ TRIM28 MAP2K1 TLR4 JUND IL18 RELA GNA11 MAPK9 CASP3 ERN1 SULT2A1 MAPK1 RAF1 GNAO1 JUNB MAP3K5 MAPK3 TFAP2A PRKCA GNAI1 JUP FOSL2 GJA1 MAPK14 CRHR2 TCF4 GSK3B CRH PARP1 PRKCB MAPK8 ARHA PRKCI FOSB BRAF TGFB1 BCL2 PRKCQ MITOCHONDRIAL COMPLEX I ASSEMBLY MODEL OXPHOS SYSTEM%WIKIPATHWAYS_20260810%WP4324%HOMO SAPIENS Mitochondrial complex I assembly model OXPHOS system ND1 ND2 NUBPL ND5 ND4 ND6 NDUFS3 ND4L NDUFA13 ECSIT ACAD9 NDUFB10 NDUFAF1 TMEM186 C3orf60 TMEM126B DMAC1 DMAC2 NDUFA12 TMEM70 NDUFA10 COA1 NDUFAF6 NDUFAF4 NDUFB11 NDUFV3 NDUFV2 NDUFC2 NDUFC1 NDUFS6 NDUFS5 NDUFS4 NDUFS1 NDUFB9 NDUFB8 NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 NDUFB2 NDUFB1 TIMMDC1 NDUFA7 NDUFA6 NDUFA5 ZNF183 NDUFA3 NDUFA2 NDUFAB1 NDUFAF2 AMINO ACID TRANSPORT DEFECTS IEMS %WIKIPATHWAYS_20260810%WP5029%HOMO SAPIENS Amino acid transport defects IEMs SLC7A9 SLC3A1 SLC1A1 SLC3A2 SLC6A19 SLC7A7 CLTRN SLC6A20 SLC36A2 MIR 509 3P ALTERATION OF YAP1 ECM AXIS%WIKIPATHWAYS_20260810%WP3967%HOMO SAPIENS miR 509 3p alteration of YAP1 ECM axis THBS2 YAP1 COL1A1 COL3A1 TEAD2 TEAD3 TEAD4 GPC6 TWIST1 PBX3 EDNRA SNAI2 SPARC UREA CYCLE AND METABOLISM OF AMINO GROUPS%WIKIPATHWAYS_20260810%WP497%HOMO SAPIENS Urea cycle and metabolism of amino groups SRM ARG1 GLUD1 SMS ALDH18A1 ASS1 ASL NAGS HEL-S-29 HEL-S-5 OTC ARG2 HEL-S-20 PENTOSE PHOSPHATE METABOLISM%WIKIPATHWAYS_20260810%WP134%HOMO SAPIENS Pentose phosphate metabolism HEL-S-304 RPIA RPE HEL107 PROTEOGLYCAN BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP4784%HOMO SAPIENS Proteoglycan biosynthesis CSGALNACT1 SLC35B2 CANT1 B3GAT3 SLC26A2 XYLT2 XYLT1 CHSY1 PAPSS2 BPNT2 CHST14 CHST3 B3GALT6 EXT1 EXT2 HEMOGLOBIN SWITCHING EMBRYONIC FETAL AND ADULT%WIKIPATHWAYS_20260810%WP5605%HOMO SAPIENS Hemoglobin switching embryonic fetal and adult tal-1 HBZ HBG2 HBG1 HBE1 HBB HBA2 HBD LMO2 GATA1 LDB1 ARYLAMINE METABOLISM%WIKIPATHWAYS_20260810%WP694%HOMO SAPIENS Arylamine metabolism UGT1A9 CYP1A2 NAT2 SULT1A2 SULT1A1 UGT1A4 JOUBERT SYNDROME%WIKIPATHWAYS_20260810%WP4656%HOMO SAPIENS Joubert syndrome RAB8A DVL1 TMEM138 PCM1 DVL3 CETN2 BBS4 CEP290 NPHP1 NEK8 INVS NPHP3 OFD1 TMEM237 UNC119 SUFU ZNF423 CEP164 FLNA RP2 KAT5 TCTN3 CEP41 TCTN2 B9D2 TCTN1 RHEB BBS9 BBS7 CEP97 CC2D2A BBS5 MTOR ARMC9 RPGRIP1L CCP110 ARR3 ARL2 MYO6 TMEM216 PCNT RAB3IP MRE11A CEP104 SHH ARL3 RAD50 ARL13B TMEM67 INPP5E PARP1 PIBF1 ATM BBS2 MKS1 BBS1 ATF4 ARHA CPLANE1 TMEM231 PDE6D TTC8 TMEM17 AHI-1 PDE6A B9D1 PDE6G OVARIAN INFERTILITY%WIKIPATHWAYS_20260810%WP34%HOMO SAPIENS Ovarian infertility CDKN1B PGR SYNE2 CCND2 FMR1 FSHR TSC2 TSC1 PTGER2 MTOR NR1i1 FIGLA TBP DAZL ZP3 MSH5 ZP2 DMC1 INHA GJA4 RAD51 NCOR1 CDK4 CEBPB NR5A1 ATM EGR1 LHCGR SMPD1 PRLR CREB1 NR3A2 MALE INFERTILITY%WIKIPATHWAYS_20260810%WP4673%HOMO SAPIENS Male infertility CDK9 PSAT1 GPX1 MTHFD1 SHMT1 XRCC3 MTRR ERCC2 PEMT HMGA1 PON2 PON1 TMEM132E MMP2 CREBBP NR3A2 SIRPA SOX5 CYP26B1 H3-4 DND1 NFE2L2 DAZL MSH5 H4C9 CCNK PRMT6 NQO1 PRDM9 SIRPG HEL110 EPSTI1 SLC16A7 RAG1 NANOS1 MAS1L PRM2 TRIP13 PRM3 CHD2 SPATA17 MSH4 EP300 TSSK4 DDX4 DAZ4 DAZ3 VCX DAZ2 STRA8 MOV10L1 H2BW1 TAS2R38 PUM2 PIWIL2 PIWIL1 SLC46A1 TNFSF6 PIWIL4 ETV5 BCL2 SPO11 FOLH1 HORMAD2 MSMB PACRG TEX15 CXXC1 APOB UBE2B OR2W3 HEL-S-61p P1 USP26 POLG CDC42BPA MLH3 BRCA2 CTCFL SEMG1 BRDT MMP9 KDM3A AHRR XPC CYP1A1 THBS1 AHR TCN2 SRD5A2 MTR CYP17A1 FAT10 NOS2 TNF RFC1 PMS2 REC8 GNAO1 ERCC1 PEX10 XRCC5 MDM2 PARP1 ATM CLU AGO2 INSR ABCB1 ZINC HOMEOSTASIS%WIKIPATHWAYS_20260810%WP3529%HOMO SAPIENS Zinc homeostasis MT1M SLC30A10 SLC30A7 SLC30A6 SLC30A9 SLC30A8 SLC30A2 SLC30A5 SLC30A4 SLC39A11 SLC30A1 SLC39A10 MT4 SLC39A13 MT3 SLC39A12 MT1A SLC39A14 MTF1 MT1F MT1G MT1B MT1E MT2A SLC39A9 SLC39A6 SLC39A5 SLC39A8 SLC39A2 SLC39A1 SLC39A3 SENESCENCE AND AUTOPHAGY IN CANCER%WIKIPATHWAYS_20260810%WP615%HOMO SAPIENS Senescence and autophagy in cancer IGF1 HRAS ATG14 IRF-1 SQSTM1 SERPINB2 CXCL14 PTEN PLAT BMP2 ING1 GABARAPL2 SH3GLB1 GABARAPL1 TNLG1B AKT1S1 IFI16 CREG1 RSL1D1 UVRAG IL24 GABARAP THBS1 CXCL1 COL3A1 IGF1R CEBPB SLC39A2 IGFBP7 SLC39A1 HMGA1 CXCL8 SLC39A3 CDKN2A MAP1LC3C MLST8 SMAD4 PCNA IL6ST RB1 IL1B KMT2A CDKN1B IRF7 SRC MAP2K3 MAP2K1 RNASEL MTOR MAP1LC3A CCL3 IFNG MAPK1 IFNB1 RAF1 RB1CC1 CDC25B LAMP2 JUN ATG3 ATG10 DKFZp762B153 INS AMBRA1 BMI1 MAPK14 IGFBP5 COL1A1 IL1A IL6R GSK3B ATG16L1 MDM2 DKFZp686F0183 COL10A1 MMP14 INHBA ATG12 IL3 ULK1 BRAF IL6 TGFB1 BCL2 SPARC VTN CDKN1A CD44 RAC1 PAK1 P38 MMP2 PATHWAY%WIKIPATHWAYS_20260810%WP3303%HOMO SAPIENS RAC1 PAK1 p38 MMP2 pathway NFKB1 HRAS PAK1 STAT3 BIRC5 SOS1 NRAS BAD BAX MSH2 ITGB1 NFKBIA RS1 ANGPTL1 TNIP2 TNIP3 EGFR MMP2 ERBB2 FOXO1 CASP9 ANGPT4 SRC NOS2 RELA MAPK9 PIK3R1 EIF4EBP1 MAPK1 MAPK12 RAC1 MAPK13 MAPK11 MAPK3 PTPN11 MAPK14 YAP1 RAD51 NCK1 MYC IKBKB GRB14 MAPK8 IKBKG CRK GRB7 STAT5B PXN ANGPT1 CHUK ANGPT2 GRB2 CELLS AND MOLECULES INVOLVED IN LOCAL ACUTE INFLAMMATORY RESPONSE %WIKIPATHWAYS_20260810%WP4493%HOMO SAPIENS Cells and molecules involved in local acute inflammatory response KNG1 ITGA4 IL1A CXCL8 TNF HEL-S-62p SELPLG IL6 SELP VCAM1 C6 C7 ITGB1 SNARE COMPLEX MACHINERY IN EXOCYTOSIS%WIKIPATHWAYS_20260810%WP5621%HOMO SAPIENS SNARE complex machinery in exocytosis RPH3A VAMP2 STXBP5 GDI1 STXBP6 UNC13A SYT1 STXBP1 SYP SNAP25 STX1B NAPA CACNA1B CACNA1A CPLX1 RIMS1 LDLRAD4 INTRONIC SNP EFFECT ON COVID PATIENTS%WIKIPATHWAYS_20260810%WP4904%HOMO SAPIENS LDLRAD4 intronic SNP effect on COVID patients TGFBR1 TMEPAI SMAD2 ATG16L1 NEDD4 TGFBR2 MITOCHONDRIAL COMPLEX IV ASSEMBLY%WIKIPATHWAYS_20260810%WP4922%HOMO SAPIENS Mitochondrial complex IV assembly COX2 COX7B COX7C COX7A2 COX6A1 COX17 COXFA4 COX8A COX5A COX11 SURF1 COX6B1 COX19 COX16 COX18 TACO1 HIGD1A PET117 COX14 COA6 COX10 COA3 PET100 FAM36A CMC1 TMEM177 PNKD SMIM20 COX3 COX1 EBSTEIN BARR VIRUS LMP1 SIGNALING%WIKIPATHWAYS_20260810%WP262%HOMO SAPIENS Ebstein Barr virus LMP1 signaling NFKB1 TRAF6 TRAF1 MAP3K14 CXCL8 TRADD TNF IKBKB PDLIM7 RELA MAPK8 CCL5 IKBKG MAP3K7 IFNB1 MAPK1 CCL20 IRAK1 CHUK NFKB2 NFKBIA GANGLIO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260810%WP5299%HOMO SAPIENS Ganglio series sphingolipid metabolism NEU4 HEL-S-111 ST8SIA6 ST8SIA1 SIAT4C NEU3 HEXA B3GALT4 ST8SIA5 ST3GAL5 B4GALNT1 ST3GAL1 MEASLES VIRUS INFECTION%WIKIPATHWAYS_20260810%WP4630%HOMO SAPIENS Measles virus infection NFKB1 CSNK2A3 CSNK2A2 CSNK2B STAT1 STAT3 JAK1 OAS3 OAS2 CCND1 HSPA2 IL2 HSPA1A ADAR CASP9 BCL2L1 PIK3CD PIK3R3 BBC3 PIK3R2 PIK3R1 IRF9 CSNK2A1 EIF2S1 EIF3S3 CD3G CD3E CD3D STAT5B IL6 MAVS TNFSF6 BCL2 CYCS RIGI TBK1 HEL-S-72p IL12B IL12A IFIH1 IFNAR2 IFNA13 IFNA14 JAK3 APAF1 IFNA16 TYK2 IFNA17 TP73 BAK1 EIF2AK4 IFNAR1 IFNA10 BAD IRAK1 STAT2 BAX HEL70 FADD IFNA21 NFKB2 NFKBIA MYD88 IFNA5 IFNA4 IFNA7 IFNA6 IFNA1 IFNA2 TNFAIP3 IFNA8 CLEC4M CASP8 LNIR IRAK4 FOS RCHY1 RAB9B IRF3 TRAF3 IL2RG IL1B TRAF6 CDKN1B CD209 TLR9 IL2RA IRF7 IL2RB CCND3 TLR7 CCND2 EIF2AK2 TLR4 FCGR2B RELA MAPK9 CCNE2 CASP3 CCNE1 IFNB1 RAB9A MAPK10 JUN MX1 EIF2AK1 CDK6 IL1A CDK4 CDK2 TRADD IKBKB MAPK8 IKBKG IKBKE CD46 MAP3K7 CHUK NFKBIB SMITH MAGENIS AND POTOCKI LUPSKI SYNDROME COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5381%HOMO SAPIENS Smith Magenis and Potocki Lupski syndrome copy number variation NFKB1 RAB8A PCK1 HEL-S-133P MAP3K14 NR1H3 STAT3 HES6 CARM1 FOXA1 TRAF3IP1 TNFSF13 SHMT1 RRAGA FOXA2 PEMT RMI1 ATPAF2 TOP3A COPS8 MYH2 NR1H2 CREB1 BIRC2 ITPK1 GPR85 TTC26 IRF8 IFT172 IFT52 CFL2 MED9 RAB10 IFT80 PRKAA1 LIMK1 APP IFT22 CLEC16A COPS6 IFT81 IFT27 IFT57 BCL2L11 IFT46 MTOR IFT25 PRKAG2 PARD3 RB1CC1 PRKAB1 BLM IFT70B ATG101 RPTOR YAP1 ROCK1 IFT74 MYC ARHA PRKCI IFT20 ETV5 CLUAP1 G6PC1 PER1 BCL6 TFEB CRY2 CRY1 RNF41 GPS1 CLTB ARG2 PTEN BAX DRC1 FLCN MYD88 MLST8 PARK2 FHOD1 FERD3L ALKBH5 MAEA DENR IL1B MIGA1 ARMC8 RAI1 TOM1L2 LLGL1 DRC5 DRC7 DRC8 FLII COPS7A TLR4 PLD6 TNF RAB39B COPS4 COPS5 TNFRSF13B RELA PARD6B GDI2 WWTR1 WDR41 RMI2 DRC10 SMCR8 WDR26 MIEF2 RASD1 RMND5A CLTC FNIP1 JUN CLTA FNIP2 GRIP1 RANBP9 MYO16 MKLN1 GID4 MYO15A CDC2 DRG2 C9orf72 ULK1 PPP1R14A PARTHANATOS CELL DEATH SIGNALING PATHWAY%WIKIPATHWAYS_20260810%WP5585%HOMO SAPIENS Parthanatos cell death signaling pathway AIFM1 PARP1 WHITE FAT CELL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP4149%HOMO SAPIENS White fat cell differentiation CEBPD NR1H3 WNT10B DDIT3 TCF7L1 EVI1 INS RORA TLE3 ZNF423 NR2F2 CEBPA CEBPB KLF2 NR3C1 KLF4 IRF4 CTNNA1 STAT5B GATA3 EGR2 GATA2 PPARG CREB1 RARA FOXO1 KLF5 IRF3 KLF15 TGFB SMAD SIGNALING%WIKIPATHWAYS_20260810%WP5382%HOMO SAPIENS TGFB Smad signaling WWTR1 TGFBR1 SMAD4 YWHAG SMAD2 TGFBR2 POSTN SPARC CTGF TGFBR3 PRIMARY OVARIAN INSUFFICIENCY%WIKIPATHWAYS_20260810%WP5461%HOMO SAPIENS Primary ovarian insufficiency HAX1 PSMC3IP DCAF17 WT1 CCDC185 MGME1 C10orf2 MND1 NLRP11 FMR1 XPNPEP2 SPATA33 PPM1B TGFBR3 POLR3H BMP15 NR5A1 EIF2B5 RECQL4 AMHR2 EIF4ENIF1 NR3A2 SALL4 POLR2C FSHR PCCA FOXL2 PCCB HSD17B1 HSD17B4 BLM FIGLA DAZL ZP3 PGRMC1 MSH5 ERAL1 DMC1 EIF2B2 BMP6 MSH4 BNC1 STRA8 ATG9A NUP107 POLG BRCA2 SOX8 CENPE LARS2 LAMC1 COX10 TP63 MST1R GNAS CLPP CYP17A1 NOTCH2 STAR SLX4 FANCM NBN FANCL ALOX12 FANCA STAG3 EIF2B1 RFWD3 PRORP ANTXR1 MEIOSIN POF1B RAD51 MEIOB SIL1 NANOS3 KHDRBS1 PREPL NOBOX AARS2 AIRE ATM AMH HMMR WDR62 SYCE1 SOHLH1 WRN KASH5 SOHLH2 BMPR1A LMNA SWI5 HELQ DIAPH2 H1-8 HROB LHX8 MCMDC2 MCM9 ELAVL2 C1orf146 MRPS22 SPIDR ZAR1 SIX6OS1 MONOAMINE GPCRS%WIKIPATHWAYS_20260810%WP58%HOMO SAPIENS Monoamine GPCRs HTR1F HTR1A HRH2 DRD1 DRD5 DRD3 DRD4 HTR1E HTR1D HTR1B HTR2B CHRM3 HTR2A ADRA1B ADRA1A CHRM1 ADRA1D ADRB3 CHRM2 ADRB1 HTR5A CHRM4 ADRB2 CHRM5 HTR4 HTR6 HTR7 ADRA2C ADRA2B ADRA2A DRD2 HRH1 22Q11 2 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4657%HOMO SAPIENS 22q11 2 copy number variation syndrome PAX3 EMC10 POLR2A FGFR2 RELN TSKS ZDHHC8 GLUD1 CDC42 RCC1 C22orf39 THAP7 ASF1A RTN4R RTL10 NPRL2 ACTA2 TRMT2A ESS2 CYP26C1 PRODH KLHL22 GP5 LRRC74B SEPT8 MRPL40 DGCR6L DGCR8 TNPO1 SCARF2 MED15 DGCR2 GP1BB C16orf35 GP1BA SREBF2 FOXA2 RTN4 SLC7A4 GNB1L DEPDC5 CCDC188 hCG_1641087 ARVCF HIRIP3 DROSHA RANBP1 EGFR ZNF74 RAN SEPT5 CDC45 VWF NKX2-5 CYP26B1 CYP26A1 RAF1 GBX2 HIRA H4C9 SHH FGF8 GP9 BCL2 FGF10 CLDN3 SLC25A1 SNAP29 PLK1 CLDN1 RORC CRKL HES1 CLDN5 HDAC3 PARK2 FOXC2 FOXC1 FGFR1 DRD2 SLC2A4 SHOC2 ALDH1A2 PITX2 UFD1L P2RX6 GSC2 HEL-S-80p RBX1 NCOR1 CLTCL1 HAND2 CDH15 TXNRD2 PAK4 TBX1 SERPIND1 HEL25 FLUOROACETIC ACID TOXICITY%WIKIPATHWAYS_20260810%WP4966%HOMO SAPIENS Fluoroacetic acid toxicity ALDH3A2 CS ALDH2 ALDH9A1 ACO2 ACSS2 GENES ASSOCIATED WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS%WIKIPATHWAYS_20260810%WP5033%HOMO SAPIENS Genes associated with the development of rheumatoid arthritis HLA-DRB1 TRAF1 IL2RA SLC22A4 CD40 CCR6 FCRL3 PTPN22 PADI4 CD244 CTLA4 PHF19 STAT4 BLK MHC2TA IL6ST ITGAV ENTEROCYTE CHOLESTEROL METABOLISM%WIKIPATHWAYS_20260810%WP5333%HOMO SAPIENS Enterocyte cholesterol metabolism MVK APOB LDLR MSMO1 APOA4 ACAT2 TM7SF2 EBP SC5D MGAT1 DHCR24 LBR MVD ABCG8 ABCG5 NPC1L1 CD36 HSD17B7 DHCR7 DGAT1 FABP2 HMGCS1 IDI1 DKFZp434B2017 SLC27A4 FDFT1 FDPS CYP51A1 ABCA1 SQLE MTTP HMGCR IL1 SIGNALING%WIKIPATHWAYS_20260810%WP195%HOMO SAPIENS IL1 signaling IL1B HSPB2 NFKB1 TRAF6 PELI1 HEL-S-71 MAP3K2 PRKCZ MAP2K3 IL1R1 MAP2K1 MAP3K14 MAP2K2 RELA PIK3R2 MAPK9 UBE2V1 PIK3R1 SQSTM1 MAPK1 IRAK1 IRAK2 MAP2K6 MAP3K7IP1 JUN MAPK3 PTPN11 NFKBIA MAPK14 TAB3 MYD88 IL1A IKBKB ATF2 MAPK8 IKBKG MAPKAPK2 MAP3K7 REL PLCG1 MAP2K4 IRAK3 ECSIT MAP3K1 IRAK4 CHUK NFKBIB VITAMINS A AND D ACTION MECHANISMS%WIKIPATHWAYS_20260810%WP4342%HOMO SAPIENS Vitamins A and D action mechanisms NR1i1 RXRA RARA PURINE METABOLISM%WIKIPATHWAYS_20260810%WP4792%HOMO SAPIENS Purine metabolism PNP ADSL IMPDH1 ADA AMPD1 ADSS XDH APRT HEL-S-70p DGUOK ENERGY METABOLISM%WIKIPATHWAYS_20260810%WP1541%HOMO SAPIENS Energy metabolism CAMK2G TFAM PRKAA1 CAMK4 MED1 NRF1 PRKAB2 PRKAG1 PRKAG2 NR1C1 RXRA NR1C2 GABPA PRKAB1 PRKAG3 MEF2D MAPK14 ESRRA MEF2C GSK3B PRKAA2 EP300 MEF2B ATF2 PPP3CA PPP3CC NCOA1 HDAC1 FOXO3A SIRT1 PPARG PPARGC1A SIRT3 CREB1 TFB1M UCP3 TFB2M MYBBP1A UCP2 PPRC1 PPP3R1 PPARGC1B PRMT1 FOXO1 PPP3R2 BIOMARKERS FOR UREA CYCLE DISORDERS%WIKIPATHWAYS_20260810%WP4583%HOMO SAPIENS Biomarkers for urea cycle disorders OTC F10 GLS2 HEL-S-20 ARG1 GPT F7 ASS1 ASL NAGS ANTIVIRAL AND ANTI INFLAMMATORY EFFECTS OF NRF2 ON SARS COV 2 PATHWAY%WIKIPATHWAYS_20260810%WP5113%HOMO SAPIENS Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway SLC7A11 HMOX1 IL12A IL1B NFKB1 TMPRSS2 TNF RELA ACE2 CCL2 RXRA NFE2L2 KEAP1 NFKBIA NQO1 GCLC GCLM GUCY1B1 CXCL8 IKBKB IKBKG MMP3 IL6 CHUK GUCY1A2 IRF3 GDNF RET SIGNALING AXIS%WIKIPATHWAYS_20260810%WP4830%HOMO SAPIENS GDNF RET signaling axis SLIT2 WT1 ALDH1A2 EYA1 SOX17 GDNF TCF2 RET IFT27 IFT25 GREM1 AGTR2 ROBO1 LHX1 PAX2 GATA3 SALL1 BMP4 SIX2 GLI3 ROBO2 FOXC2 FOXC1 HOXC11 SOX11 FAT4 HOXD11 HOXA11 SPRY1 OSTEOARTHRITIC CHONDROCYTE HYPERTROPHY%WIKIPATHWAYS_20260810%WP5373%HOMO SAPIENS Osteoarthritic chondrocyte hypertrophy SOX9 NFKB1 JUND FGFR2 COL2A1 STAT3 CTGF RELA KDR MAPK1 JUNB JUN IBSP MAPK3 NGF RUNX2 FOSL1 HIF1A PRKCA FOSL2 FGF23 COL1A1 COL3A1 LAMTOR1 CEBPB AKT3 RELB COL10A1 DDR2 VEGFA ACAN FOSB NTRK1 VHL FOS opn FGFR4 FGFR1 CNMD FGFR3 P4HTM GANC 15Q11Q13 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5407%HOMO SAPIENS 15q11q13 copy number variation CALM1 STX1A STX1B MTMR10 GOLGA8R KLF13 OTUD7A GOLGA8O GOLGA8Q TRPM1 GOLGA8H FAN1 ANKRD2 HDAC1 CREBBP SPEF1 SMC5 KAT2B SMC6 ANKRD32 GOLGA8T CXADR NSMCE3 NSMCE2 NSMCE1 GOLGA8K GOLGA8J APP GJD3 CANX MYZAP NECAB3 RELA LYPD6 ENTREP2 CCL5 UBN1 FANCD2 MLSN2 SLF2 CGN CDC42BPB SIN3A TJP1 GJA1 TJP3 STXBP1 GJC2 CHRNA7 FARNESOID X RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP2879%HOMO SAPIENS Farnesoid X receptor pathway FGF19 CYP8B1 SLCO2B1 CYP3A4 SLC27A5 ABCB11 CYP7A1 FKBP5 SULT2A1 ABCB4 NR1H4 BAAT IP6K3 PPARGC1A RXRA NR0B2 UGT2B4 SPHINGOLIPID METABOLISM INTEGRATED PATHWAY%WIKIPATHWAYS_20260810%WP4726%HOMO SAPIENS Sphingolipid metabolism integrated pathway CERS3 CERS6 CERK SGMS1 SGMS2 SGPP2 SGPP1 LASS1 CERS5 UGT8 UGCG SGPL1 SPTLC2 SMPD1 DEGS1 KDSR DEGS2 CERS2 SPHK2 SPHK1 SPTLC1 PLPP3 PLPP2 PLPP1 TCA CYCLE AND DEFICIENCY OF PYRUVATE DEHYDROGENASE COMPLEX PDHC %WIKIPATHWAYS_20260810%WP2453%HOMO SAPIENS TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc HEL-S-26 DLAT FH PDHA1 PCK1 ACLY CS PC SDHA HEL60 SUCLG2 DLD HEL-S-32 OGDH TGIF DISRUPTION OF SHH SIGNALING%WIKIPATHWAYS_20260810%WP3674%HOMO SAPIENS Tgif disruption of Shh signaling SHH FGF8 NKX2-1 TGIF2 FOXG1 SMAD2 GLI3 NODAL TGIF1 AMPLIFICATION AND EXPANSION OF ONCOGENIC PATHWAYS AS METASTATIC TRAITS%WIKIPATHWAYS_20260810%WP3678%HOMO SAPIENS Amplification and expansion of oncogenic pathways as metastatic traits TCF7L2 LEF1 VEGFA TCF7L1 SRC VHL CYTIP NOTCH1 TNC VCAM1 POSTN CXCR4 LACTATE SHUTTLE IN GLIAL CELLS%WIKIPATHWAYS_20260810%WP5314%HOMO SAPIENS Lactate shuttle in glial cells HEL-76 SLC1A2 SLC16A7 SLC2A3 SLC16A3 SLC4A4 HEL-S-133P NUDT14 CA4 HEL-S-281 METABOLISM OF SPHINGOLIPIDS IN ER AND GOLGI APPARATUS%WIKIPATHWAYS_20260810%WP4142%HOMO SAPIENS Metabolism of sphingolipids in ER and Golgi apparatus B4GALT1 CERS3 CERK SGMS1 SGMS2 SGPP2 SGPP1 UGT8 UGCG GALNT1 SGPL1 KDSR B4GALT2 GALNT16 B3GALT2 SPHK2 B3GALT1 SPHK1 B4GALNT1 CELL INTERACTIONS IN PANCREATIC CANCER MICROENVIRONMENT%WIKIPATHWAYS_20260810%WP5284%HOMO SAPIENS Cell interactions in pancreatic cancer microenvironment HLA-DRB1 CCR2 CXCL12 CSF2 ITGB6 CXCR4 CCL5 KDR CTLA4 CSF2RA VEGFA CCL2 NRP1 CSF1R TGFB1 TNFSF6 LAG3 CSF1 IFITM2 CXCR3 BAG3 CD80 CCR5 TCA CYCLE AKA KREBS OR CITRIC ACID CYCLE %WIKIPATHWAYS_20260810%WP78%HOMO SAPIENS TCA cycle aka Krebs or citric acid cycle FH MDH2 CS SDHC SDHD SDHA SUCLG2 DLD SDHB OGDH ACO2 IDH3B SUCLA2 SUCLG1 GLIAL CELL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2276%HOMO SAPIENS Glial cell differentiation FREP1 CNP MBP HEL70 GAP43 PRE IMPLANTATION EMBRYO%WIKIPATHWAYS_20260810%WP3527%HOMO SAPIENS Pre implantation embryo PBX1 DNMT3L SOX8 MYBL1 IRX5 HNRNPAB TCF7L1 ESRRA HMGA1 KLF4 E2F5 EGR1 ATP1A1 ELAVL1 MACROH2A2 SOX11 FOXQ1 SOX2 FOXD1 ZFP42 NKX2-1 DPPA3 DDIT3 SMARCA4 MXD1 TFAP2B SIX3 MTA3 NANOGNB AQP9 AQP3 NR3C2 ZFP36 KHSRP BATF3 ARGFX PADI6 BARX2 ZFP36L2 TEAD4 LEUTX TPRX1 DLX2 MOS DPRX IRF4 ZSCAN4 GATA3 CDX2 GATA2 FOSB TBX3 POU5F1 ZAR1 PARKINSON 39 S DISEASE PATHWAY%WIKIPATHWAYS_20260810%WP2371%HOMO SAPIENS Parkinson 39 s disease pathway SLC6A3 APAF1 HEL-117 UBE2J2 CASP3 SNCAIP CCNE2 GPR37 SNCA CCNE1 MAPK12 MAPK13 MAPK11 EPRS1 TH HTRA2 MAPK14 DDC UBE2J1 UBB LRRK2 UBE2L6 ATXN2 UBE2L3 SEPT5 SYT11 CASP6 UBE2G1 PINK1 CASP2 UBE2G2 PARK2 UBA7 CYCS HEL-S-67p CASP9 ESTROGEN SYNTHESIS AND METABOLISM%WIKIPATHWAYS_20260810%WP5276%HOMO SAPIENS Estrogen synthesis and metabolism CYP1B1 CYP1A2 CYP3A4 HSD17B10 UGT2A2 CYP2C19 UGT1A8 UGT2B7 HSD17B8 CYP3A7 CYP2C9 SULT1E1 HSD17B1 HSD17B2 HSD17B4 HSD17B3 HSD17B7 UGT1A10 CANCER IMMUNOTHERAPY BY PD 1 BLOCKADE%WIKIPATHWAYS_20260810%WP4585%HOMO SAPIENS Cancer immunotherapy by PD 1 blockade NFKB1 HLA-DRB1 HLA-A STAT3 CD3G CD3E BATF CD3D NFAT5 PDCD1LG2 PDCD1 CD8B NFATC3 ZAP70 IFNG CD8A NFATC1 LCK NFATC4 JUN NFATC2 PTPN11 LNCRNA IN CANONICAL WNT SIGNALING AND COLORECTAL CANCER%WIKIPATHWAYS_20260810%WP4258%HOMO SAPIENS lncRNA in canonical Wnt signaling and colorectal cancer CTBP2 LEF1 LRP5 CSNK2A3 CSNK2A2 NKD1 LRP6 DKK2 NKD2 APC RUVBL1 DKK4 SFRP4 DVL1 CSNK2B DVL2 DVL3 WNT3 WNT4 FZD1 WNT10B TCF7L2 WNT10A FZD3 FZD2 APC2 TCF7L1 FZD7 FZD9 WNT7A FOSL1 CSNK1A1 ROR1 CCND1 CDK8 MACROH2A2 CTNNBIP1 CCND3 SOX17 CCND2 ROR2 CSNK1A1L CTBP1 SFRP1 NLK EZH2 CER1 WIF1 WNT2B SOST ATF3 JUN SFRP5 TFAP2A FZD5 KREMEN1 CDK6 FZD8 NOTUM WNT1 RYK GSK3B CSNK2A1 MYC PORCN WNT3A CHD8 FZD10 WNT7B hCG_2014051 FRAT1 TCF3 SENP2 DKK1 CXXC4 MAP3K7 WNT5B AXIN1 AXIN2 WNT16 FRAT2 ESTROGEN METABOLISM%WIKIPATHWAYS_20260810%WP697%HOMO SAPIENS Estrogen metabolism NQO1 UGT1A1 STS CYP1A1 UGT1A3 CYP1B1 UGT1A9 CYP1A2 CYP3A4 SULT1A1 UGT2B7 GSTM1 SULT1E1 ARSL ESTROGEN SIGNALING%WIKIPATHWAYS_20260810%WP712%HOMO SAPIENS Estrogen signaling MAPK14 GNGT1 NFKB1 SP1 MAP2K1 GPER IKBKB MAPK9 GNB1 IKBKG GNAS MAPK1 BRAF CREB1 JUN CHUK FOS BCL2 KIT RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP304%HOMO SAPIENS Kit receptor signaling SRC HRAS MAP2K1 MAP2K2 STAT1 STAT3 VAV1 PIK3R2 BTK SOS1 PIK3R1 INPP5D MAPK1 SOCS1 FYN BAD RAF1 MAPK3 PTPN6 PRKCA PTPN11 LYN MAPK14 GRB10 RPS6KA1 CRKL RPS6 SH2B2 RPS6KB1 EP300 PRKCB MAPK8 CBL DOK1 SHC1 CRK GRB7 STAT5B FOXO3A SOCS6 MATK PLCG1 KITLG KIT TEC GRB2 GAB2 CELL CYCLE%WIKIPATHWAYS_20260810%WP179%HOMO SAPIENS Cell cycle SKP2 CDK7 TTK CCNB1 RBL2 RBL1 TFDP1 TFDP2 E2F4 E2F5 CCND1 MCM7 CDC45 ORC1L ORC6 ORC3 ORC2 SMAD4 CDC6 DBF4 PCNA MCM3 SKP1 MCM5 MCM6 E2F3 CCNH CDC25B HEL2 MYC EP300 WEE1 HEL-S-93 CDC14B PTTG2 ANAPC13 PKMYT1 WEE2 CDKN1A YWHAQ HEL-S-1 CDC23 E2F2 CDC27 STAG1 ANAPC7 MAD1L1 YWHAG CCNA2 PLK1 ANAPC5 ANAPC1 ANAPC2 ANAPC10 ANAPC11 FZR1 CDKN2D CDKN2B HDAC2 CDKN2C CDKN2A HDAC1 CDC20 RB1 CDKN1B CCND3 SMC3 CCND2 CHEK2 PTTG1 CHEK1 RAD21 SMC1A CCNE2 SMC1B STAG2 CCNE1 PRKDC ESPL1 CCNB3 CCNB2 MAD2L2 SFN GADD45B GADD45A MCM2 CDC2 CDKN1C GADD45G CDK6 RBX1 CDK4 SMAD2 CDK2 MDM2 GSK3B ATM ATR TGFB1 EFFECT OF OMEGA 3 PUFA ON HUNTINGTON 39 S DISEASE PATHWAYS%WIKIPATHWAYS_20260810%WP5470%HOMO SAPIENS Effect of omega 3 PUFA on Huntington 39 s disease pathways NFKB1 CYP46A1 OPA1 ABCG1 AKT1S1 HMGCS1 SREBF2 SP1 PRKAA2 KIF5A EGFR NR1H2 CYP51A1 CREB1 BCL2L1 MAP2K1 MAP3K10 RHEB PRKAA1 MAP2K2 PIK3CD PIK3R3 TSC2 TSC1 PIK3R2 SLC12A2 PIK3R1 BCL2L11 PRKAB2 MTOR EIF4EBP1 PRKAG1 PRKAG2 MAPK1 RAF1 EIF4E PRKAB1 MBP DHCR7 PRKAG3 MAPK3 DEPTOR RICTOR RPTOR RPS6KA5 AKT3 RPS6KB1 HEL-S-29 BNIP3 ABCA1 NEUROD1 IL6 HAP1 BCL2 ABCG4 PI3 RAB3GAP1 APOE BDNF GABRB3 GABRB2 GABRB1 HRAS GABRE GABRQ GABRA2 GABRP GABRA6 GABRA5 PIK3R5 BAD GABRA4 GABRA3 PTEN BAX PIK3R4 GABRG3 GABRG1 PIK3C2G PIK3C2B NTRK2 HDAC2 REST CASP8 MLST8 HDAC1 PPARGC1A HTT IL1B MAPK9 CASP3 SLC12A5 C1QA MAPK10 SIN3A IKBKB MAPK8 MAP2K4 AHI-1 EGF HMGCR NEUROGENESIS REGULATION IN THE OLFACTORY EPITHELIUM%WIKIPATHWAYS_20260810%WP5265%HOMO SAPIENS Neurogenesis regulation in the olfactory epithelium SOX2 PAFAH1B1 NEUROG3 FAIM AGRN CXCL12 NTRK3 RELN RET APP STAT3 MAP1B KDM1A RTN4R NUMB NOTCH1 DISC1 MRE11A NGF RTN4 ID1 ASCL1 CDK5 CDK5R1 MEF2C TCF4 GSK3B HES1 PLXND1 MYC NTRK2 GIG8 TCF3 IL17A ERBB4 PSEN1 NEUROD1 NTRK1 VLDLR MAP2 NGFR NDEL1 GHRL LRP8 BDNF NRG1 DAB1 FEMALE STEROID HORMONES IN CARDIOMYOCYTE ENERGY METABOLISM%WIKIPATHWAYS_20260810%WP5318%HOMO SAPIENS Female steroid hormones in cardiomyocyte energy metabolism APOB ESRRA ACADM ACLY NR1C1 MTTP STK11 PPARGC1B HADHB SLC2A4 MAPK AND NFKB SIGNALING INHIBITED BY YERSINIA YOPJ%WIKIPATHWAYS_20260810%WP3849%HOMO SAPIENS MAPK and NFkB signaling inhibited by Yersinia YopJ TRAF6 IKBKG NFKB1 MAPK1 RAF1 MAP3K14 MAP2K6 MAP3K1 CHUK RRAS IKBKB NFKBIA PI3K AKT SIGNALING%WIKIPATHWAYS_20260810%WP4172%HOMO SAPIENS PI3K Akt signaling IGF1 GNGT1 GYS2 NFKB1 GNGT2 OSMR PHLPP2 PHLPP1 RELN FGFR2 VEGFB OSM VEGFC VEGFD CSHL1 GHB3 CSF3R IL4 CHRM1 FGF3 JAK1 COMP FGF6 STK11 FGF9 TNR F2R COL4A6 EFNA5 EFNA4 CHAD FGF20 FGF22 FGF17 PRL EFNA1 EFNA3 FGF14 EGFR EFNA2 GNB2 CCND1 FGF18 GNB1 GNB4 IL7R FGF13 FGF12 HSP90AB1 PRLR VWF CREB1 PPP2R5B PPP2R5A GYS1 PPP2R5D IL3RA THBS4 GNG3 GNG2 GNG5 GNG4 PPP2R3C GNG7 GNG8 BCL2L1 ANGPT4 PPP2R2D HEL-S-125m BCL2L11 CSF1R CHRM2 CSF1 EPO PDGFA IRS1 INS FGF4 NTF4 MYB RPTOR FGF8 LAMA1 IL6R LAMA3 LAMC2 EIF4B LAMB3 RPS6 LAMB1 HGF RPS6KB1 RPS6KB2 FLT3LG FOXO3A VEGFA COL9A1 IL3 COL9A3 IL6 COL9A2 KITLG KIT FGF10 BDNF G6PC1 IFNAR2 IFNA13 IFNA14 GNB3 TGFA IFNA16 IFNA17 IFNAR1 IFNA10 PIK3R5 PTEN TNC G6PC2 IL7 IFNA21 NGF IFNA5 IFNA4 IFNA7 SGK2 NTRK2 IFNA6 IFNA1 IFNA2 GNB5 IFNA8 MLST8 SYK opn IL2RG THBS3 CDKN1B IL2RA IL2RB LPAR4 CCND3 CCND2 TLR4 RELA CCNE2 CCNE1 IFNB1 FLT3 FLT4 ITGA2B ITGB8 PCK2 ITGB7 CDK6 ITGA4 ITGA2 CDK4 CDK2 MDM2 ITGA7 ITGA6 EPHA2 NTRK1 NGFR ANGPT1 INSR LAMB4 ANGPT2 FGFR4 FGFR3 PCK1 NTF3 GHR PDGFRA IBSP EPOR GH1 ITGB3 ITGAV FGF23 RBL2 PRKAA2 FGF21 IL2 CASP9 IGF2 MAP2K1 RHEB PRKAA1 COL2A1 MAP2K2 SGK1 PIK3CD PIK3R3 TSC2 TSC1 PIK3R2 PIK3R1 MTOR EIF4EBP1 MAPK1 FGF7 RAF1 EIF4E MCL1 MAPK3 FGF19 PKN3 AKT3 CREB3L3 CREB3L4 MYC PPP2R2A CREB3L2 PPP2R5E PPP2R1A ATF4 PKN2 PKN1 TNFSF6 BCL2 PPP2R5C GRB2 CDKN1A GHB2 CSH2 G6PC3 JAK3 COL6A6 HRAS COL6A5 PPP2CA CREB3 SOS1 SOS2 CREB5 ATF6B NRAS BAD PPP2R3B PPP2R3A LAMB2 LAMA4 PPP2R2C PPP2R2B ITGB1 ITGA1 XB CSF3 FLT1 LAMC1 THBS2 THBS1 COL1A2 COL4A2 IGF1R COL4A1 COL6A1 EIF4E1B ITGB6 ATF2 FGFR1 ITGB4 CD19 PPP2R1B PIK3AP1 KDR RAC1 PRKCA COL1A1 GSK3B FGF2 IKBKB TCL1B TCL1A IKBKG KPG_010 CDC37 COL4A4 DDIT4 COL4A3 COL4A5 LPAR2 LPAR3 GNG10 PDGFD CHUK PDGFC LAMA5 EGF GNG12 PDPK1 GNG11 VTN LPAR1 GNG13 TYROSINE KINASE INHIBITORS IN GLIOBLASTOMA%WIKIPATHWAYS_20260810%WP5494%HOMO SAPIENS Tyrosine kinase inhibitors in glioblastoma RPTOR JAK3 HRAS AKT3 TGFA TYK2 RHEB STAT3 EREG TSC2 TSC1 SOS1 SOS2 MTOR NRAS RAF1 PTEN JAK1 BTC EGF GRB2 SEROTONIN HTR1 GROUP AND FOS PATHWAY%WIKIPATHWAYS_20260810%WP722%HOMO SAPIENS Serotonin HTR1 group and FOS pathway HTR1F HTR1A MAPKAPK3 HTR1E MAP2K3 HTR1D MAP2K1 HTR1B MAP2K2 STAT3 HTR2A MAPK1 GNAO1 MAP2K6 MAPK3 GNAI3 GNAI1 RASGRF1 MAPK14 RPS6KA5 RAP1A ARHA MAPKAPK2 BRAF CREB1 MAP3K1 FOS PDPK1 AUTOSOMAL RECESSIVE OSTEOPETROSIS PATHWAYS%WIKIPATHWAYS_20260810%WP4788%HOMO SAPIENS Autosomal recessive osteopetrosis pathways TRAF6 NFKB1 TNFSF11 CLCN7 OSTM1 RAB7A SNX10 PLEKHM1 TCIRG1 TNFRSF11A IKBKB OXYTOCIN SIGNALING%WIKIPATHWAYS_20260810%WP2889%HOMO SAPIENS Oxytocin signaling OXTR HINT1 PATHWAY%WIKIPATHWAYS_20260810%WP5523%HOMO SAPIENS HINT1 pathway GTF2H3 NFKB1 GTF2H4 ERCC2 CDK7 TCF4 MNAT1 RUVBL1 KARS1 HINT1 RUVBL2 MAPK9 CCNH USF2 JUN FOS GTF2H2C_2 SH3RF1 NFATC2 GTF2H2 NICOTINE EFFECT ON CHROMAFFIN CELLS%WIKIPATHWAYS_20260810%WP1603%HOMO SAPIENS Nicotine effect on chromaffin cells CACNA1C CHRNB4 CHRNA3 CACNA1G OSTEOPONTIN SIGNALING%WIKIPATHWAYS_20260810%WP1434%HOMO SAPIENS Osteopontin signaling NFKB1 MAPK1 MAP2K1 MAP3K14 MMP9 CHUK MAPK3 opn IKBKB ITGB3 ITGAV RELA FOLATE METABOLISM%WIKIPATHWAYS_20260810%WP176%HOMO SAPIENS Folate metabolism APOB LDLR NFKB1 GPX2 SERPINA3 GPX1 GPX4 SAA4 GPX3 IZUMO1R FOLR3 GPX6 SAA1 FOLR2 FGA SAA2 IL4 MTHFD1 MTHFD2 PLAT PLG SHMT1 HEL-S-78p HEL-S-51e F7 CBS NFKB2 MTRR HEL-S-44 CTH CRP ALB IL2 MTR SLC19A1 MAT1A DHFR IL1B FLAD1 TNF RELA IFNG CCL2 FOLR1 CSF1 INS MPO F2 ABCA1 SCARB1 IL6 SLC46A1 INSR HBB MTHFS HBA2 ATM SIGNALING IN DEVELOPMENT AND DISEASE %WIKIPATHWAYS_20260810%WP3878%HOMO SAPIENS ATM signaling in development and disease MDC1 NFKB1 PPP5C AURKB TP53BP1 TRIM28 CHEK2 PPP2CA CHEK1 NBN TSC2 SMC1A RNF20 MTOR ATMIN PRKDC CEP63 MAPK12 MAPK13 STK11 MAPK11 MRE11A MAPK14 HMGN1 RAD50 CDK5 NHEJ1 RNF8 CDK2 ATM HEL-S-102 ATF2 PPM1D LMNB2 ATR RBBP8 IKBKG RIF1 RNF168 KAT5 CHOLESTEROL SYNTHESIS DISORDERS%WIKIPATHWAYS_20260810%WP5193%HOMO SAPIENS Cholesterol synthesis disorders MVK HMGCS1 MSMO1 IDI1 EBP SC5D DHCR24 MVD LBR FDFT1 FDPS HSD3B2 CYP51A1 SQLE DHCR7 HMGCR NANOPARTICLE MEDIATED ACTIVATION OF RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP2643%HOMO SAPIENS Nanoparticle mediated activation of receptor signaling SRC HRAS MAP2K1 MAP2K2 PIK3CD MAPK9 SOS1 NRAS MAPK1 MAPK12 RAF1 MAPK13 MAPK10 MAPK11 ITGB1 ITGA1 MAPK14 COL1A1 AKT3 EGFR MAPK8 PXN AREG TLN1 GRB2 HIPPO YAP SIGNALING%WIKIPATHWAYS_20260810%WP4537%HOMO SAPIENS Hippo YAP signaling YAP1 MAP4K2 MINK1 TNIK TEAD2 TEAD3 TEAD4 MAP4K3 LATS1 STK38L NF2 LATS2 WWTR1 MAP4K1 RASSF1 HEL-S-31 MAMMARY GLAND DEVELOPMENT EMBRYONIC DEVELOPMENT STAGE 1 OF 4%WIKIPATHWAYS_20260810%WP2813%HOMO SAPIENS Mammary gland development embryonic development stage 1 of 4 ALPL TERT MYC ITGA6 TNF SFRP1 NRG3 CCND1 ZEB2 ERBB4 TGFB1 CLDN4 ITGB1 SMALL LIGAND GPCRS%WIKIPATHWAYS_20260810%WP247%HOMO SAPIENS Small ligand GPCRs S1PR1 S1PR3 CNR2 TBXA2R S1PR2 GPR50 S1PR4 CNR1 PTGDR PTGER4 PTGER1 PTGER2 PTGER3 PTGFR PTGIR MTNR1A MTNR1B LPAR1 IRON METABOLISM DISORDERS%WIKIPATHWAYS_20260810%WP5172%HOMO SAPIENS Iron metabolism disorders STEAP3 TFRC FTH1 TFR2 SLC40A1 HAMP FTL UQCRFS1 PANK2 HFE CYBRD1 CP TF HEPH SLC11A2 MECHANOREGULATION AND PATHOLOGY OF YAP TAZ VIA HIPPO AND NON HIPPO MECHANISMS%WIKIPATHWAYS_20260810%WP4534%HOMO SAPIENS Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms PS1TP5BP1 YWHAQ SRC ITGB4 PAK1 MAPK9 WWTR1 ACTA2 MAPK10 ITGB3 ITGB1 HEL-S-31 LIMD1 ITGB8 ITGB7 YAP1 MAP4K2 TEAD2 SGMS1 TEAD3 MAP4K3 TEAD4 ITGB6 LATS1 ACTG2 MAPK8 NF2 ACTG1 CTNNA1 PAK6 PAK4 MAP4K1 ACTA1 NPHP1 DELETION SYNDROME%WIKIPATHWAYS_20260810%WP5399%HOMO SAPIENS NPHP1 deletion syndrome NPHP1 PTK2B MAPK1 RPGRIP1L FLNA INVS FLNB MAPK3 SARS COV 2 B 1 1 7 VARIANT ANTAGONISES INNATE IMMUNE ACTIVATION%WIKIPATHWAYS_20260810%WP5116%HOMO SAPIENS SARS CoV 2 B 1 1 7 variant antagonises innate immune activation TRAF6 IKBKE TOMM70 IFNB1 MAVS RIGI TBK1 IRF3 TRAF3 ENDOTHELIN PATHWAYS%WIKIPATHWAYS_20260810%WP2197%HOMO SAPIENS Endothelin pathways CALM1 MAP2K1 HEL-S-7a ECE1 COX2 MYLK ADRA1A MAPK1 RAMP1 PTGIR RAF1 GNA15 HEL-S-14 EDNRA RIIAD1 CALCRL PRKCA GNAI1 EDN1 CALCA EDNRB ADRB1 NPY GNB5 CAD GNAS NPY1R PLCB1 ATP2A2 GNG13 MYL1 SULINDAC METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP2542%HOMO SAPIENS Sulindac metabolic pathway CYP1B1 CYP1A2 MSRA MSRB2 MSRB3 LDL INFLUENCE ON CD14 AND TLR4%WIKIPATHWAYS_20260810%WP5272%HOMO SAPIENS LDL influence on CD14 and TLR4 MAPK14 IL1B NFKB1 CREB3L3 CREB3L4 TLR4 CREB3L2 CREB3 RELA RELB ATF4 CREB5 CCL2 MAPK12 REL MAPK13 IL6 CREB1 IL10 MAPK11 CD14 NFKB2 HORMONAL CONTROL OF PUBERTAL GROWTH SPURT%WIKIPATHWAYS_20260810%WP4194%HOMO SAPIENS Hormonal control of pubertal growth spurt IGF1 GHRH GH1 GNRH1 SST FLAVAN 3 OL METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP4238%HOMO SAPIENS Flavan 3 ol metabolic pathway VITAMIN D IN INFLAMMATORY DISEASES%WIKIPATHWAYS_20260810%WP4482%HOMO SAPIENS Vitamin D in inflammatory diseases MAPK14 NFKB1 MAP2K3 NR3C1 TNF IKBKB PPP3CA RELA IKBKG NR1i1 SMAD4 NFATC1 MED14 IL6 RXRA MAP2K6 MAP3K1 CHUK PPP3R1 NFKBIA FGFR4 P G388R SIGNALING%WIKIPATHWAYS_20260810%WP5428%HOMO SAPIENS FGFR4 p G388R signaling IL10 STAT3 FGFR4 CYTOSOLIC DNA SENSING PATHWAY%WIKIPATHWAYS_20260810%WP4655%HOMO SAPIENS Cytosolic DNA sensing pathway NFKB1 CASP10 IFNA13 IFNA14 IFNA16 POLR2H IFNA17 POLR2K POLR2L POLR3GL IFNA10 POLR3A POLR3B RIPK1 POLR3C FADD POLR3D ZBP1 IFNA21 POLR3F POLR3G POLR3H NFKBIA POLR3K IL33 CYLD IFNA5 IFNA4 IFNA7 RIPK3 POLR3E IFNA6 IFNA1 IFNA2 IFNA8 CASP8 CGAS ADAR IRF3 PYCARD IL1B IRF7 IL18 RELA AIM2 CCL5 CCL4 TREX1 IFNB1 POLR2F TRADD IKBKB DKFZp686F0183 TRIM25 IKBKG MITA IKBKE ATG12 RNF125 IL6 POLR1C NLRX1 MAVS POLR1D ISG15 CHUK CCL4L2 RIGI NFKBIB TBK1 CATABOLISM OF SKELETAL MUSCLE IN CACHEXIA%WIKIPATHWAYS_20260810%WP5474%HOMO SAPIENS Catabolism of skeletal muscle in cachexia TNFSF12 IGF1 IL1B NFKB1 TNFRSF1A IL1R1 TNF STAT3 RELA MTOR MAP1LC3A JAK1 MAPK11 MSTN AKT1S1 NFKB2 NFKBIA RPTOR FBXO32 IL1A CEBPB IGF1R IL6R SMAD2 IKBKB EP300 RELB IKBKG MLST8 FOXO3A SMAD4 TRIM63 REL IL6 CHUK ACVR2A TNFRSF12A TNF ALPHA SIGNALING%WIKIPATHWAYS_20260810%WP231%HOMO SAPIENS TNF alpha signaling MAP3K8 MADD NFKB1 PSMD2 TNFRSF1A TXN PRKCZ HRAS APAF1 MAP3K14 PPP2CA SOS1 NRAS BAD BAX RIPK1 FBXW11 FADD PTPRCAP PLK1 NSMAF NFKB2 NFKBIA TAB3 PYGL NFKBIE MAP4K2 RFFL RIPK3 TNFAIP3 PIG59 CASP8 CREBBP REL KSR1 BIRC2 BTRC BIRC3 SKP1 DIABLO KSR2 CASP9 TNFRSF1B BCL2L1 MAP2K3 TNF MAPK9 CASP3 MAPK1 CYBA RAF1 RAC1 MAP2K6 MAP3K7IP1 MAP3K5 JUN MAPK3 SMPD2 OTUD7B TRAF1 CSNK2A1 TRADD IKBKB MAPK8 TRAF2 IKBKG MAP3K7 CDC37 MAP2K4 TANK MAP3K1 CHUK GRB2 NFKBIB TBK1 CREATINE PATHWAY%WIKIPATHWAYS_20260810%WP5190%HOMO SAPIENS Creatine pathway HEL-S-29 HEL-S-20 SLC6A8 HIPPOCAMPAL SYNAPTOGENESIS AND NEUROGENESIS%WIKIPATHWAYS_20260810%WP5231%HOMO SAPIENS Hippocampal synaptogenesis and neurogenesis NRXN2 MAPK14 CAMKK1 CAMKK2 RPS6KA5 DRD1 RPS6KA1 CCND2 CALM1 PRL NRXN3 CAMK2A CAMK4 HNRNPL MAPK1 PPARGC1A CREB1 BCL2 NGF PRKCA SYT2 NCAM1 BDNF NRXN1 ETHANOL METABOLISM PRODUCTION OF ROS BY CYP2E1%WIKIPATHWAYS_20260810%WP4269%HOMO SAPIENS Ethanol metabolism production of ROS by CYP2E1 SP1 CYP2E1 MAFF MAP2K1 MAFG MAP2K2 MAFK NFE2L2 MAPK8 17P13 3 YWHAE COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5376%HOMO SAPIENS 17p13 3 YWHAE copy number variation PAFAH1B1 DYNC1H1 YWHAQ DCTN5 DDC DCTN3 DBH HEL-S-1 HEL-S-77 CDK5 PPP2CA DCTN6 HEL-S-93 DCTN1 DCTN4 YWHAG DISC1 NDEL1 HEL2 TH AMP ACTIVATED PROTEIN KINASE SIGNALING%WIKIPATHWAYS_20260810%WP1403%HOMO SAPIENS AMP activated protein kinase signaling GYS2 STRADA CAB39 FASN CRTC2 EEF2K LIPE CCNB1 CCNA2 STK11 CAMKK1 ADIPOR2 CAMKK2 STRADB INS-IGF2 PRKAA2 EEF2 SLC2A4RG LEPR CPT1A PRKACG ACACA ELAVL1 GYS1 SLC2A4 PRKAA1 PIK3CD PIK3R3 TSC2 TSC1 PIK3R2 ADRA1B PIK3R1 ADRA1A PRKAB2 MTOR PRKAG1 EIF4EBP1 PRKAG2 ADIPOR1 PRKAB1 PRKAG3 ACACB RPTOR CPT1C HNF4A LEP RPS6KB1 RPS6KB2 PLCB1 INSR HMGCR PPARGC1B CDKN1A OXIDATIVE STRESS RESPONSE%WIKIPATHWAYS_20260810%WP408%HOMO SAPIENS Oxidative stress response HMOX1 NFKB1 GPX1 GPX3 CYBB HEL-75 MAPK10 JUNB NOX3 NFE2L2 MAOA NQO1 MAPK14 UGT1A3 CYP1A1 HEL-S-44 SP1 GCLC NOX5 TXNRD2 NOX4 TXN2 GSTT2 MGST1 XDH FOS LEPTIN AND ADIPONECTIN%WIKIPATHWAYS_20260810%WP3934%HOMO SAPIENS Leptin and adiponectin ADIPOR2 PRKAG1 ACACA ADIPOR1 PRKAB1 PRKAA1 LEP LEPR CPT1A DISORDERS OF FRUCTOSE METABOLISM%WIKIPATHWAYS_20260810%WP5178%HOMO SAPIENS Disorders of fructose metabolism G6PC1 ALDOB SLC5A1 SLC2A2 HEL-S-49 KHK GLYCTK HEL-S-53e PFKL FBP1 SORD ATOPIC DERMATITIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260810%WP5538%HOMO SAPIENS Atopic dermatitis mechanism and therapies IL33 IL5 OSMR JAK3 TYK2 IL1RL1 MS4A2 FCER1G STAT3 IL4 FCER1A IL13 IL13RA1 TSLP CRLF2 IL2RG TRYPTOPHAN CATABOLISM LEADING TO NAD PRODUCTION%WIKIPATHWAYS_20260810%WP4210%HOMO SAPIENS Tryptophan catabolism leading to NAD production NMRK2 NAPRT AADAT NADSYN1 HEL-S-90n NMRK1 HAAO NMNAT3 KMO TDO2 NMNAT2 KYNU AFMID IDO1 NMNAT1 NAMPT ID SIGNALING%WIKIPATHWAYS_20260810%WP53%HOMO SAPIENS ID signaling RB1 ID1 RBL2 RBL1 CDK2 GIG8 PAX5 ELK3 PAX2 ID3 CCNE1 PAX8 MYOD1 CELL DIFFERENTIATION EXPANDED INDEX%WIKIPATHWAYS_20260810%WP2023%HOMO SAPIENS Cell differentiation expanded index SOX2 MEF2D TLX2 TLX3 MEF2C LEFTY1 GIG8 HDAC5 MEF2B STAT3 KLF4 PAX7 EZH2 LEFTY2 RUNX2 TLX1 MYOD1 GLYOXYLATE METABOLISM%WIKIPATHWAYS_20260810%WP5166%HOMO SAPIENS Glyoxylate metabolism PXMP2 HAO1 HOGA1 PRODH2 GOT2 HEL-S-133P AGXT DAO SLC26A1 CONVERSION OF ANGIOTENSINOGEN TO ANGIOTENSIN II %WIKIPATHWAYS_20260810%WP4818%HOMO SAPIENS Conversion of angiotensinogen to angiotensin II CTSG REN HEL-S-130P CMA1 GLYCOGEN SYNTHESIS AND DEGRADATION%WIKIPATHWAYS_20260810%WP500%HOMO SAPIENS Glycogen synthesis and degradation GYS2 CALM1 PPP2CA PTPA PPP2R1B PHKG2 GYG1 HK3 PPP2R3B PPP2R3A GSK3A PPP2R2C PPP2R2B PYGL GSK3B PPP2R2A PPP2R5E PPP2R1A PYGB PYGM AGL PHKB PPP2R5B PHKA1 PPP2R5A PHKA2 GYS1 PPP2R5D PPP2R5C HK2 SARS COV 2 INNATE IMMUNITY EVASION AND CELL SPECIFIC IMMUNE RESPONSE%WIKIPATHWAYS_20260810%WP5039%HOMO SAPIENS SARS CoV 2 innate immunity evasion and cell specific immune response NFKB1 IFNAR2 STAT1 IFNAR1 CXCL17 STAT2 JAK1 RIPK1 FADD PPBP CXCL6 NUP98 CXCL11 LARP1 CXCL1 CXCL5 TP53I3 IL8RB hEMMPRIN CXCL9 CXCL8 CSF2 CXCL2 HDAC2 CASP8 RAE1 AP1G1 IRF3 TRAF3 TRAF6 IRF7 CXCL12 TLR7 HAVCR2 TNF CCL5 ACE2 CCL4 CCL3 CCL2 IFNB1 IL10 PF4 IFITM1 CD160 IFIT2 LAG3 TRAF5 MX1 TFAP2A CXCL13 IL6R TRADD CXCL3 EP300 DHX58 TRIM25 TRAF2 IL6 TANK TGFB1 MAVS RIGI TBK1 NUCLEOTIDE GPCRS%WIKIPATHWAYS_20260810%WP80%HOMO SAPIENS Nucleotide GPCRs LPAR4 P2RY6 LTB4R ADORA2A P2RY4 ADORA2B P2RY2 P2RY1 H19 RB E2F1 AND CDK BETA CATENIN IN COLORECTAL CANCER%WIKIPATHWAYS_20260810%WP3969%HOMO SAPIENS H19 Rb E2F1 and CDK beta catenin in colorectal cancer RB1 CSRP2 CDK8 CDK4 PMAIP1 SOX4 MED1 CCND1 POLYOL PATHWAY%WIKIPATHWAYS_20260810%WP690%HOMO SAPIENS Polyol pathway ALDOB KHK AKR1B1 SORD TRANS SULFURATION PATHWAY%WIKIPATHWAYS_20260810%WP2333%HOMO SAPIENS Trans sulfuration pathway CTH GCLM MTR CBS pcap 22Q11 2 DISTAL CNV%WIKIPATHWAYS_20260810%WP5546%HOMO SAPIENS 22q11 2 distal CNV BCR SNRPA1 SF3B5 SF3B2 PAK1 ELOC SNRPB2 SF3A1 SF3A2 PHF5A CAMK2A UBE2L3 AQR SOX9 XBP1 HEL-S-99n CAMK4 HEL-S-125m CANX HEL-S-89n RPS15 DNCL1 RPS14 RPS17 MAPK1 RPS16 DNAJB11 RPS19 RPS18 NEDD4 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPSA RPS6 FAU XAB2 RPS15A RPS3 RPS2 PPIB RPS26 RPS28 RPS29 DNAJB13 RPS20 RPS21 RPS24 RPS23 PDIA2 UBE3A RPS27A RSPH9 PARK2 RNF19B VPREB1 CWC22 ROPN1L RSPH3 RSPH6A CRNKL1 PDIA4 RAB36 PPIE DYDC1 GNAZ UBA6 CABP1 AK8 SDF2L1 SNRPD2 CWC15 SNRPD1 CHEK1 TDRD3 RSPH14 CD79B HYOU1 LRP4 SNRPD3 CD79A GGTLC2 ZNF280A PTPA IQUB HEL-S-107 CCDC116 BUD31 PLRG1 NME5 SNRPG YDJC RBM22 PPM1F SNRPE RNF113A SNRPF RILP UGGT1 PPIL1 CDC5L IGLL5 SNRPB IGLL1 YPEL1 PPIL4 PPIL6 PRPF8 RBX1 MDM2 WDR57 CBL CAMK1 SNRNP200 SNW1 ARIH1 DHX16 HFE EFFECT ON HEPCIDIN PRODUCTION%WIKIPATHWAYS_20260810%WP3924%HOMO SAPIENS Hfe effect on hepcidin production TMPRSS6 ID1 BMP6 HFE HAMP ACUTE MYELOID LEUKEMIA%WIKIPATHWAYS_20260810%WP5293%HOMO SAPIENS Acute myeloid leukemia NFKB1 LEF1 PER2 HRAS STAT3 SOS1 SOS2 TCF7L2 NRAS BAD CCNA2 TCF7L1 NR1C2 CD14 CEBPA CSF2 BCL2A1 CCND1 PIM1 MAP2K1 SPI1 MAP2K2 PIK3CD PIK3R3 RELA PIK3R2 PIK3R1 MTOR EIF4EBP1 MAPK1 ITGAM RAF1 FLT3 CSF1R RUNX1T1 MAPK3 PML RUNX1 FCGR1A JUP ZBTB16 CEBPE MPO ARAF AKT3 PIM2 MYC RPS6KB1 IKBKB RPS6KB2 IKBKG STAT5B IL3 BRAF KIT CHUK RARA GRB2 OREXIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP5094%HOMO SAPIENS Orexin receptor pathway PRKCZ PRKD1 STAT3 IL4 DKFZp686L0365 BGLAP GH1 RUNX2 IL9 CAMKK2 LHB CXCL8 DKFZp781O1323 NPY CXCL2 NOX4 CGA GNAS SLC1A2 SMAD1 CREB1 POMC GCG STAR SLC2A4 FOXO1 GNRH1 CASP9 IL1B DYNLT1 DYNLT3 FSHB MAP2K1 PRKAA1 MAP2K2 TNF SGK1 GNA11 PIK3R2 MAPK9 CASP3 PIK3R1 MTOR EIF4EBP1 MAPK1 DAGLA IL10 CCK MAPK3 NFE2L2 PRKCA HIF1A GNAI1 PTPN11 BMP7 TH MAPK14 NPFFR1 NPVF HCRT RPS6KA1 EIF4B LEP RPS6 OPRK1 RPS6KB1 PRKCB MAPK8 MAPK7 BMPR1A HCRTR2 PRKCE IL6 VHL HCRTR1 GHRL PDPK1 DISRUPTION OF POSTSYNAPTIC SIGNALING BY CNV%WIKIPATHWAYS_20260810%WP4875%HOMO SAPIENS Disruption of postsynaptic signaling by CNV RPH3A CAMK2G GRIN2B CYFIP1 SHANK1 FMR1 NRXN3 STX1A NLGN1 HOMER1 RYR2 DLG2 MAPK1 YWHAG MAPK3 SYNGAP1 TJP1 NRXN1 NRXN2 ARC NLGN3 NLGN2 DLGAP1 CAMK2D CAMK2A GRIN1 KCNQ2 AND KCNQ3 RELATED EPILEPSY%WIKIPATHWAYS_20260810%WP5599%HOMO SAPIENS KCNQ2 and KCNQ3 related epilepsy RAB11A CALM1 STX1A BACE1 SNAP25 SCN8A KCNQ2 NEDD4 KCNQ3 SCN4B VAMP2 DAG1 AKAP5 RAB1A CAMK2A ZNF547 TRAPPC3 GIGYF1 TRAPPC6B KCNQ5 FGF13 FGF12 PRRT2 PRKCE SCN2A FOXP3 IN COVID 19%WIKIPATHWAYS_20260810%WP5063%HOMO SAPIENS FOXP3 in COVID 19 IL7R STAT5B IL2RA IL2 IL2RB IL6 IL6R IL6ST STAT3 CD80 FOXP3 IL2RG PTDINS 4 5 P2 IN CYTOKINESIS PATHWAY%WIKIPATHWAYS_20260810%WP5199%HOMO SAPIENS PtdIns 4 5 P2 in cytokinesis pathway ARHA MYL2 RAB35 KIF23 EZR OCRL HEL70 SEPTIN2 RDX GIP AND GLP 1 FUNCTION BY TISSUE%WIKIPATHWAYS_20260810%WP5509%HOMO SAPIENS GIP and GLP 1 function by tissue GIP GCG PURINE METABOLISM AND RELATED DISORDERS%WIKIPATHWAYS_20260810%WP4224%HOMO SAPIENS Purine metabolism and related disorders DGUOK PNP AOX1 RRM2B MOCOS ADSL PFAS PAICS IMPDH1 ADA AMPD1 TPMT ADSS APRT XDH HEL-S-70p NEURODEGENERATION WITH BRAIN IRON ACCUMULATION NBIA SUBTYPES PATHWAY%WIKIPATHWAYS_20260810%WP4577%HOMO SAPIENS Neurodegeneration with brain iron accumulation NBIA subtypes pathway WIPI2 DCAF17 ATG14 PRKAA1 RHEB TSC2 TSC1 ATG2A MTOR PLA2G6 MAP1LC3A PANK2 RB1CC1 PIK3R4 CP STK11 ATG3 ATG10 AKT1S1 DEPTOR ATG101 RPTOR ATG16L1 DKFZp686F0183 FTL MLST8 ATG12 ACACA WDR45 C19orf12 ULK1 COASY FA2H SPTLC1 WIPI1 METABOLIC REPROGRAMMING IN COLON CANCER%WIKIPATHWAYS_20260810%WP4290%HOMO SAPIENS Metabolic reprogramming in colon cancer PDHA1 GOT2 HEL-S-133P ENO1 RPIA PSAT1 HEL-S-68p GLUD1 PSPH PFKL FASN SDHB ALDOB SLC16A3 HK3 PGAM1 HEL-S-51e ACO2 GLS TIGAR FH HEL-S-162eP MDH2 ACLY PYCR2 SUCLG2 PAICS HEL-S-30 HEL107 11P11 2 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260810%WP5348%HOMO SAPIENS 11p11 2 copy number variation syndrome ALX4 TP53I11 LEF1 LARGE2 IZUMO1 PEX3 SLC35C1 SYT13 MAPK8IP1 FREY1 SLC25A17 B4GAT1 B3GNT7 TSPAN18 CRY2 MS4A1 B4GALT4 ALKBH3 CD19 CHST6 HLA-DMB SDCBP CHST1 HBEGF EXT1 TIMP1 EXT2 ITGB1 NRXN1 SHH ITGA4 ITGA6 REST CD63 CD82 HLA-DMA GLI3 LGALS3BP IGSF8 SPPL2C CD151 PRDM11 VANGL1 ACCS PHF21A PEX16 C11orf96 FAMILIAL HYPERLIPIDEMIA TYPE 3%WIKIPATHWAYS_20260810%WP5110%HOMO SAPIENS Familial hyperlipidemia type 3 LDLR APOA4 PLTP SCARB1 VLDLR APOA2 LPL LIPC APOE GLIOBLASTOMA SIGNALING%WIKIPATHWAYS_20260810%WP2261%HOMO SAPIENS Glioblastoma signaling BRCA2 PRKCZ HRAS FGFR2 DKFZp781B1423 NRAS PTEN PDGFRA PIK3C2G SPRY2 PIK3C2B FOXO4 IGF1R EGFR CDKN2B CCND1 CDKN2C ERBB3 CDKN2A ERBB2 PLCG2 PLCG1 FGFR1 FOXO1 RB1 CDKN1B SRC CCND2 MAP2K3 MAP2K1 MAP2K2 PIK3CD MSH6 TSC2 TSC1 PIK3R2 PIK3R1 CCNE1 MAPK1 RAF1 MAP2K6 MAPK3 IRS1 PRKCA CDK6 CDK4 ARAF AKT3 CDK2 MDM2 ATM EP300 PRKCB CBL PRKCI NF1 FOXO3A PRKCH MAP2K5 BRAF MAP2K4 PDPK1 GRB2 CDKN1A PRKCQ VEDOLIZUMAB THERAPY FOR INFLAMMATORY BOWEL DISEASE%WIKIPATHWAYS_20260810%WP5512%HOMO SAPIENS Vedolizumab therapy for inflammatory bowel disease SELE ITGB7 ITGA4 ITGA2 SELPLG MADCAM1 VCAM1 ITGB1 BDNF SIGNALING IN NEURODEVELOPMENT%WIKIPATHWAYS_20260810%WP5541%HOMO SAPIENS BDNF signaling in neurodevelopment WASL CDC42 NPTX2 PAK1 STAT3 LINGO1 TIAM1 RTN4R EEF2K TCF7L1 EEF2 IQGAP3 PLCG1 CREB1 CASP9 PARD6A CFL2 MAP2K1 LIMK1 MAP2K2 PIK3CD BCL2L11 MTOR EIF4EBP1 MAPK1 PARD3 RAF1 EIF4E MAP3K5 MAPK3 HEL2 IRS1 BMP7 ROCK1 MYC RPS6KB1 RPS6KB2 PRKCB ARHA HEL-S-93 PRKCI FOXO3A PRKCH PRKCE BCL2 CYCS GRB2 BDNF YWHAQ LEF1 HEL-S-1 PRKCZ HRAS APAF1 TP73 ARHGAP35 DOCK7 SOS1 TCF7L2 NRAS YWHAG BAD BAX FADD NFKBIA RAPGEF1 HEL-S-47e NTRK2 SH2B2 SORT1 KIDINS220 MAPKAPK2 SHC1 CASP8 SMPD1 TRAF6 HEL-S-15 PARD6B RAC1 JUN MAPK11 PRKCA PTPN11 GSK3B ROCK2 TRADD IKBKB FRS2 MAPK8 MAPK7 IKBKG CRK MAP2K5 MAP2K4 NGFR MAP3K1 CHUK PDPK1 NEURAL CREST CELL MIGRATION DURING DEVELOPMENT%WIKIPATHWAYS_20260810%WP4564%HOMO SAPIENS Neural crest cell migration during development MMP9 PIK3CD PIK3R3 PAK1 STAT3 F2RL2 TIAM1 TWIST1 PIK3R5 RAC1 PIK3R4 JUN ARF1 TRIO AKT3 CDH11 EPHB6 EPHB2 EPHB1 EPHB3 ARHA MMP2 PAK6 PAK4 NGFR FOS EPHB4 BDNF GLYCOSPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260810%WP5292%HOMO SAPIENS Glycosphingolipid metabolism NEU4 B4GALT4 GBA2 B4GALT5 UGT8 UGCG A4GALT NEU3 B3GALT2 B3GNT5 B3GALT1 ST3GAL5 B4GALNT1 GLA A3GALT2 ANGIOGENESIS%WIKIPATHWAYS_20260810%WP1539%HOMO SAPIENS Angiogenesis MAPK14 FLT1 TIMP3 SRC MMP9 FGFR2 FGF2 KDR VEGFA CREBBP MAPK1 SMAD1 PLCG1 ANGPT1 PDGFRA HIF1A EFFECTS OF MFN2 MUTATION%WIKIPATHWAYS_20260810%WP5443%HOMO SAPIENS Effects of MFN2 mutation DYNC2I2 DYNC1H1 TRAK1 ATAT1 RHOT1 KIF1B RABAC1 RAB7A DYNC1LI2 MFN2 CASP3 DCTN1 CASP8 DYNC1I1 SNCA BAX MAP2 RAB3B SYPL1 DYNC2H1 ALTERED GLYCOSYLATION OF MUC1 IN TUMOR MICROENVIRONMENT%WIKIPATHWAYS_20260810%WP4480%HOMO SAPIENS Altered glycosylation of MUC1 in tumor microenvironment IKBKG NFKB1 MUC1 IL6 CHUK TNF IKBKB RELA NFKBIA SPHINGOLIPID METABOLISM IN SENESCENCE%WIKIPATHWAYS_20260810%WP5121%HOMO SAPIENS Sphingolipid metabolism in senescence RB1 S1PR1 S1PR2 S1PR5 CDK4 CDK2 TERT SGMS2 PRKCB SGPP1 UGCG MTOR PLCB1 RPP38 MAPK1 DEGS1 KDSR CERS2 SPHK1 SPTLC1 GLB1 PRKCA CDKN1A 2Q13 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP5222%HOMO SAPIENS 2q13 copy number variation syndrome IL1R1 POLR2H POLR2K STAT1 POLR2L CHTM1 ZC3H8 PSD4 ARL14 CKAP2L POLR1G FBLN7 SOCS1 IL36A TMEM87B IL36B SLC20A1 RGPD8 IL36RN TTL IL1RL2 IL36G NT5DC4 IL1F10 ANAPC1 CSF2 IL37 IL2 SOCS3 PLCG2 TULP1 ARF6 IL1B BCL2L11 MERTK MAPK1 RAC1 CSF1 POLR2F IL1RN CXCL13 IL1A GATA3 IL23A POLR1A IL6 POLR1C POLR1D POLR1F GRB2 POLR1H MIR 517 RELATIONSHIP WITH ARCN1 AND USP1%WIKIPATHWAYS_20260810%WP3596%HOMO SAPIENS miR 517 relationship with ARCN1 and USP1 ID1 ARCN1 USP1 GIG8 CDKN1A BEMPEDOIC ACID THERAPY IN ATHEROSCLEROSIS AND METABOLIC SYNDROME%WIKIPATHWAYS_20260810%WP5500%HOMO SAPIENS Bempedoic acid therapy in atherosclerosis and metabolic syndrome G6PC1 G6PC3 PRKAA1 SLC27A2 MAPK9 PRKAB2 PRKAG1 PRKAG2 MAPK1 MAPK12 MAPK13 MAPK10 PRKAB1 MAPK11 G6PC2 PRKAG3 MAPK3 ACACB MAPK14 PCK2 ACLY CRP PRKAA2 HMGA1 MAPK8 ACACA COPPER HOMEOSTASIS%WIKIPATHWAYS_20260810%WP3286%HOMO SAPIENS Copper homeostasis APC BACE1 APP SCO1 CASP3 MT4 MT3 MT1A MTF1 MT1F PTEN MT1G COX17 MT1B JUN MT1E SLC11A2 ATP7B ATP7A MT2A SLC31A2 COX11 ATOX1 ADAM9 XAF1 HEL-S-44 STEAP1 SP1 STEAP2 ADAM10 STEAP3 CCS GSK3B MDM2 PRNP ADAM17 CCND1 FOXO3A SLC31A1 COMMD1 STEAP4 FOXO1 SIGNALING LIPIDS%WIKIPATHWAYS_20260810%WP5584%HOMO SAPIENS Signaling lipids CYP8B1 HPGD CYP7A1 PTGS2 GPX4 FADS2 ALOX15 ALOX12 ALOX5 EPHX2 CYP4F2 LTC4S CYP7B1 CYP2C9 PLA1A CYP27A1 PLCB1 PRXL2B PTGES COX1 PLA2G1B CYP2B6 BDNF TRKB SIGNALING%WIKIPATHWAYS_20260810%WP3676%HOMO SAPIENS BDNF TrkB signaling ADCY1 HRAS MAP2K1 RHEB HOMER1 TSC2 TSC1 SOS1 EEF2K MTOR NRAS EIF4EBP1 MAPK1 TRPC3 ARC RPS6KA1 NTRK2 TRPC6 RPS6KB1 GRIN1 DLG4 SHC1 PLCG1 BRAF CREB1 GRB2 BDNF GAB2 HISTONE MODIFICATIONS%WIKIPATHWAYS_20260810%WP2369%HOMO SAPIENS Histone modifications KMT2A EHMT1 EZH1 SET H3C8 EZH2 SUV39H2 SUV39H1 SETDB1 SETD5 H4C9 SETD2 EED HIST1H4L KMT2E H3C15 SETD4 SETD3 SETD8 SMYD5 SETD9 KMT2C SETD6 KMT2B DOT1L SETD7 PRDM2 SMYD2 SMYD1 KMT5B SMYD4 SMYD3 AEBP2 H4C7 MLL2 KMT5C SETD1B SETD1A SETDB2 SETMAR ASH1L SETBP1 H3F3B T CELL ANTIGEN RECEPTOR TCR PATHWAY DURING STAPHYLOCOCCUS AUREUS INFECTION%WIKIPATHWAYS_20260810%WP3863%HOMO SAPIENS T cell antigen receptor TCR pathway during Staphylococcus aureus infection LAT MAP3K8 NFKB1 CALM1 MAP3K14 PAK1 SOS1 IL4 NFKBIA CSF2 RRAS IL2 CD8A CD40LG ITK PLCG1 FOS CHP1 AHSA1 IL5 MAP2K1 MAP2K2 TNF MAPK9 PDCD1 IFNG RAF1 FYN IL10 JUN MAPK3 PTPN6 DAG1 CDK4 GSK3B NCK1 IKBKB CD3D CBL GRAP2 IKBKG CTLA4 MAP3K7 ZAP70 LCK LCP2 CARD11 CHUK BCL10 ICOS GRB2 PRKCQ NFATC2 PTPRC IL2 SIGNALING%WIKIPATHWAYS_20260810%WP49%HOMO SAPIENS IL2 signaling IL2RA IL2RB JAK3 HRAS CISH MAP2K1 MAP2K2 STAT1 STAT3 SOS1 PIK3R1 PTK2B MAPK1 FYN RAF1 JAK1 MAPK3 PTPN11 CRKL RPS6 RPS6KB1 RPS6KB2 CBL SHC1 STAT5B FOXO3A IL2 SOCS3 SYK LCK GRB2 NMI IL2RG GAB2 INFLUENZA A VIRUS INFECTION%WIKIPATHWAYS_20260810%WP1438%HOMO SAPIENS Influenza A virus infection BCL2 LUNG PATHOLOGY OF COVID 19%WIKIPATHWAYS_20260810%WP5146%HOMO SAPIENS Lung pathology of COVID 19 IFIH1 IL1B NFKB1 CXCL11 TLR8 TLR7 CXCL9 TLR3 CSF2 IL18 TNF MITA CCL2 IL6 CGAS MAVS RIGI TBK1 IRF3 TRANSCRIPTIONAL REGULATION OF MEMORY B CELL DIFFERENTIATION%WIKIPATHWAYS_20260810%WP5491%HOMO SAPIENS Transcriptional regulation of memory B cell differentiation BCR POU2AF1 NFKB1 CDKN1B TLR9 BCL2L1 TLR8 CCND3 TLR7 CCND2 IL21R TLR5 BCL6 TLR4 SPI1 TLR3 CD79B STAT3 CD79A TLR10 ID3 EZH2 TNFRSF13C LYN MEF2C POU2F2 TCF4 CD40 MYC MEF2B IRF4 TCF3 CDKN2A SYK IL6 TLR1 CDKN1A SPIB IRF8 T CELL MODULATION AND DESMOPLASIA IN PANCREATIC CANCER%WIKIPATHWAYS_20260810%WP5078%HOMO SAPIENS T cell modulation and desmoplasia in pancreatic cancer VTCN1 VSIR TIGIT HLA-A B2M TNFRSF9 CXCL12 FAP TNLG2B HAVCR2 CD226 ARG1 VEGFB VEGFC VEGFD CXCR4 PDCD1 NR1i1 IL4 IDO1 IL10 IL13 PDGFA NT5E SHH TNLG5A CD40 CCL17 CCL22 ENTPD1 CTLA4 PDCD1LG2 VEGFA LGALS9 CD40LG TNFRSF4 IL6 TGFB1 TNFSF6 PDGFD PDGFC ICOS CD80 4P16 3 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5365%HOMO SAPIENS 4p16 3 copy number variation NSD2 TMEM129 FAM53A CKAP5 LETM1 UBE2J2 NICOL1 TACC3 NELFCD SOS1 PIK3R1 NELFA NELFE MAPK1 NAT8L NELFB MAPK3 FGF2 CLTCL1 FRS2 CBL POLN PLCG1 SLBP GRB2 H3F3B FGFR3 ERI1 CATALYTIC CYCLE OF MAMMALIAN FLAVIN CONTAINING MONOOXYGENASES FMOS %WIKIPATHWAYS_20260810%WP688%HOMO SAPIENS Catalytic cycle of mammalian flavin containing monooxygenases FMOs FMO4 FMO5 ENDOPLASMIC RETICULUM STRESS RESPONSE IN CORONAVIRUS INFECTION%WIKIPATHWAYS_20260810%WP4861%HOMO SAPIENS Endoplasmic reticulum stress response in coronavirus infection PPP1R1B PPP1R15A PPP1R14C XBP1 EIF2AK2 PPP1R3C PPP1R7 sm-M20 HEL-S-89n PPP1R15B PPP1R13B ERN1 PPP1R11 PPP1R2 MAP1LC3A PPP1R8 PPP1R10 PPP1R16B DDIT3 PPP1R14B PPP1R3G PPP1R3F PPP1R3A PPP1R3E PPP1R1C PPP1R3D PPP1R14D EIF2AK1 PPP1CC PPP1R9A HEL-S-80p PPP1R1A PPP1R12C EIF2S1 MAPK8 ATF4 MBTPS1 PPP1R14A MBTPS2 BCL2 PPP1R3B FIBROTIC RESPONSE OF TRABECULAR MESHWORK CELLS TO TGFB3 AND ENPP2 IN AQUEOUS HUMOR%WIKIPATHWAYS_20260810%WP5545%HOMO SAPIENS Fibrotic response of trabecular meshwork cells to TGFB3 and ENPP2 in aqueous humor RHO ACTA2 COL1A1 MAPK10 TGFB1 LPA STAT3 ENPP2 CTGF MAPK8 MAPK9 EXTRAFOLLICULAR AND FOLLICULAR B CELL ACTIVATION BY SARS COV 2%WIKIPATHWAYS_20260810%WP5218%HOMO SAPIENS Extrafollicular and follicular B cell activation by SARS CoV 2 IL12A BCR IFNAR2 TBX21 GPR183 BCL6 MS4A1 CCR7 HEL-S-62p CXCR4 IL4 TNFSF13 EBI3 CD69 CD40 CRP SELL ZEB2 IL2 CD40LG SYK TNLG7A FOXO1 SH2D1A IRF8 CXCL12 TLR7 XBP1 TLR4 TNF MFGE8 BASH CD79A CD19 BTLA CD22 PDCD1 IFNG IL10 IFITM1 IFIT2 BACH2 AID ITGAX TMSB10 C4A FCRL5 CD1D SLAMF7 CXCL13 IL-21 CXCR5 CCL21 CR1 PAX5 IRF4 MAF CR2 CD82 IL6 ISG15 CCL19 ICOS CD80 HEL-S-72p PTPRC ULTRACONSERVED REGION 339 MODULATION OF TUMOR SUPPRESSOR MICRORNAS IN CANCER%WIKIPATHWAYS_20260810%WP4284%HOMO SAPIENS Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer CCNE2 GENES AND COMPLEXES INVOLVED IN THE DNA REPAIR PATHWAYS%WIKIPATHWAYS_20260810%WP4946%HOMO SAPIENS Genes and complexes involved in the DNA repair pathways UNG NTHL1 POLD3 MUTYH POLD4 MBD4 BRCA2 CDK7 POLK NEIL3 DDB2 DDB1 CETN2 XPA POLE4 TDG MSH3 MSH2 POLE2 HMGB1 POLE3 XPC RAD54B SMUG1 ERCC2 FEN1 PARP2 ERCC5 FAN1 RAP1A PCNA NEIL2 H2AX RFC3 FAAP24 RFC4 BRIP1 LIG1 CHEK1 RFC2 POLD2 USP1 RPA1 MSH6 FANCM APEX1 NBN CENPX RPA3 RFC1 PMS2 FANCL REV1 FANCA FANCB FANCD2 FANCE PALB2 PRKDC FANCG CCNH TERF2 FANCF RAD51C ERCC1 CUL4B GTF2H2C_2 CENPS MRE11A GTF2H2 GTF2H3 RAD52 GTF2H4 RAD50 WDR48 XRCC5 REV3L POLM RAD51 POLI POLL RBX1 NHEJ1 APEX2 MNAT1 PARP1 POLE ATM ATR WRN CUL4A MPG OGG1 PNKP ENTEROHEPATIC CIRCULATION OF BILE ACIDS%WIKIPATHWAYS_20260810%WP5396%HOMO SAPIENS Enterohepatic circulation of bile acids ABCC2 SLC51A SLC51B ABCC3 FABP6 SLC10A2 ABCB11 ABCB1 SLCO1B1 IL9 SIGNALING%WIKIPATHWAYS_20260810%WP22%HOMO SAPIENS IL9 signaling CDK9 JAK3 MAP2K1 MAP2K2 STAT1 STAT3 PIK3R2 PIK3R1 STAT5B IL9R MAPK1 JAK1 MAPK3 GRB2 IL9 IL2RG MIRNA DEGRADING ENZYMES%WIKIPATHWAYS_20260810%WP4316%HOMO SAPIENS miRNA degrading enzymes EXOSC4 XRN1 PNPT1 ALSTROM SYNDROME%WIKIPATHWAYS_20260810%WP5202%HOMO SAPIENS Alstrom syndrome IFT172 DNM3 ALMS1 CEP192 IFT81 IFT27 IFT25 VCP IFT74 TFDP2 BLOC1S4 VCPIP1 SMO BLOC1S6 BLOC1S1 E2F4 CIMAP3 SNAPIN GPR161 RFX2 ACTN4 DTNBP1 RABL2B RFX3 RFX1 TUBG1 RILPL1 MYO5B STX5A PTCH1 CEP19 ALBUTEROL AND BUDESONIDE THERAPY FOR ASTHMA%WIKIPATHWAYS_20260810%WP5503%HOMO SAPIENS Albuterol and budesonide therapy for asthma MYL2 ADCY3 MYL3 ADCY1 ADCY8 ADCY6 ADCY5 NR3C1 PRKAR1B ADRB2 PLCB3 PLCB4 GNAS PLCB1 ADCY9 PLCB2 CREB1 PRKAR1A MYL4 MYL1 COMPLEMENT AND COAGULATION CASCADES%WIKIPATHWAYS_20260810%WP558%HOMO SAPIENS Complement and coagulation cascades HEL-S-62p F10 SERPINF2 PLAT PLG F3 HEL-S-78p F5 F7 F2R F8 F9 CFD CFB VWF C1QB C1QA F13B CLTC C1S C6 SERPINA1 C8G C7 C9 MASP2 MASP1 KNG1 THBD CD55 C1QC BDKRB1 SERPING1 KLKB1 CR1 PROS1 PLAUR CLU F2 C3AR1 CR2 CD46 CPB2 CFH SERPINC1 C4B_2 CFI C5AR1 TFPI LMAN1 SERPIND1 PROC AKT SIGNALING AND ARTD FAMILY MEMBERS%WIKIPATHWAYS_20260810%WP5531%HOMO SAPIENS AKT signaling and ARTD family members PARP3 PHLPP1 PIK3CD PIK3R3 TSC2 TSC1 PIK3R2 PIK3R1 MTOR PIK3R5 PIK3R4 STK11 PIK3C2G MAPKAP1 PIK3C2B RICTOR RPTOR AKT3 PARP2 GSK3B PARP1 ATM IKBKG MLST8 SIRT1 FOXO1 POLYCYSTIC KIDNEY DISEASE PATHWAY%WIKIPATHWAYS_20260810%WP2571%HOMO SAPIENS Polycystic kidney disease pathway IGF1 PKD1 HRAS SFRP4 DVL1 VEGFB DVL2 DVL3 WNT3 WNT4 FZD1 WNT9A WNT10B WNT8B WNT10A NRAS FZD3 FZD2 FZD7 FZD9 STK11 WNT7A SSTR2 FLT1 IGF1R PRKAA2 CCND1 PRKACG ERBB2 GNAS PLCG2 KCNN4 FOS CFTR SRC ADCY6 PRKAA1 RHEB MAP2K2 TNF TSC2 TSC1 GNA11 SLC12A2 KDR PRKAB2 MTOR PRKAG1 WNT8A PRKAG2 WNT2B PRKAB1 JUN PRKAG3 MAPK3 GNAI3 GNAI1 FZD5 FZD4 FZD8 RPS6KA1 WNT1 GSK3B MYC WNT3A FZD10 IKBKB WNT7B WNT5B PDE1A BRAF WNT9B EGF WNT16 NIFEDIPINE ACTIVITY%WIKIPATHWAYS_20260810%WP259%HOMO SAPIENS Nifedipine activity BDKRB2 KDR HEL-S-44 PTK2B MAPK1 CYP3A4 PCNA MAP2K1 FERROPTOSIS%WIKIPATHWAYS_20260810%WP4313%HOMO SAPIENS Ferroptosis AIFM2 HEL-S-64p ACSL3 GPX4 SLC39A14 SLC38A1 CP CBS AKR1C1 AKR1C2 CTH BACH1 GCLM SLC39A8 HEL-S-102 FDFT1 NOX4 ACSL6 FTL FACL4 MAP1LC3C ACSL5 SLC3A2 POR SLC7A11 HMOX1 COQ2 ACSL1 ALOX15 PHKG2 MAP1LC3A CYBB SLC11A2 DKFZp762B153 GCLC STEAP3 TFRC FTH1 PRNP IREB2 SLC40A1 DKFZp686F0183 VDAC3 CISD1 SAT2 TF CHMP6 CHMP5 DPP4 HMGCR FTMT PCBP1 LPCAT3 VALPROIC ACID PATHWAY%WIKIPATHWAYS_20260810%WP3871%HOMO SAPIENS Valproic acid pathway CYP2A6 CYP2C9 HDAC1 ABAT EHHADH HSD17B10 ACADSB HADHB CYP2B6 IVD NRF2 PATHWAY%WIKIPATHWAYS_20260810%WP2884%HOMO SAPIENS NRF2 pathway GPX2 GPX3 NR1C2 ABCC3 ABCC5 CYP2A6 GCLM SLC5A5 HEL126 CES2 GSTM1 CES1 FGF13 HSP90AB1 SLC6A19 SLC2A3 MAFG GSTM4 DNAJB1 UGT1A7 RXRA NFE2L2 HBEGF SERPINA1 ABCC2 NQO1 UGT1A1 UGT1A9 PTGR1 GCLC FTH1 SLC6A18 SLC6A17 HGF SLC6A16 SLC5A7 SLC5A8 SLC5A9 CES8 CES3 EPHA3 MGST3 MGST2 SLC5A1 ADH7 SLC5A2 SLC6A20 SLC5A3 GSTM3 SLC5A4 GSTM2 HEL-S-128m SLC6A5 SLC6A7 HEL-S-22 SLC6A9 TXN GSTM5 SLC6A2 SLC6A3 TGFA SLC2A14 SLC2A11 TGFBR2 UGT1A4 SLC2A10 UGT2B7 SLC2A13 SQSTM1 SLC39A11 SLC39A10 SLC39A13 SLC39A12 SLC39A14 HEL-75 SLC6A11 SMVT GSTA5 GSTA4 GSTA3 SLC39A9 SLC39A6 SLC39A5 SLC39A8 SLC39A2 SLC39A1 SLC39A3 ALDH3A1 EGR1 FTL SLC6A13 GSTT2 SLC2A9 MAFF SRXN1 SLC2A6 SLC6A8 SLC2A7 SLC2A8 HEL-S-10 SLC2A4 HEL-S-25 HMOX1 SLC7A11 SLC5A12 SLC5A10 KEAP1 UGT1A3 AGER SLC2A2 SLC2A12 EPHA2 CYP4A11 TGFB1 ME1 NRG1 TARGET OF RAPAMYCIN SIGNALING%WIKIPATHWAYS_20260810%WP1471%HOMO SAPIENS Target of rapamycin signaling DDIT4L PRKAA1 RHEB CDC42 ULK2 TSC2 TSC1 PRKAB2 MTOR PRKAG1 EIF4EBP1 PRKAG2 RAC1 PRKAB1 PRKAG3 AKT1S1 PRKCA RRAGA MAPKAP1 RRAGB PRR5 RRAGD RICTOR RPTOR FKBP1A IDI1 PRKAA2 RPS6KB1 MLST8 DDIT4 ULK1 HMGCR INTERACTIONS OF NATURAL KILLER CELLS IN PANCREATIC CANCER%WIKIPATHWAYS_20260810%WP5092%HOMO SAPIENS Interactions of natural killer cells in pancreatic cancer NCR3LG1 MICB TIGIT CD96 CD226 NCR1 TNF NCR3 CCL5 CCL4 CCL3 CCL2 IFNG BMI1 FCGR3A KLRK1 ADAM10 PRF1 CCL1 MICA MYC CSF2 ADAM17 GATA2 FOXO1 SRF AND MIRS IN SMOOTH MUSCLE DIFFERENTIATION AND PROLIFERATION%WIKIPATHWAYS_20260810%WP1991%HOMO SAPIENS SRF and miRs in smooth muscle differentiation and proliferation MEF2D MYOCD MEF2C CCND2 CAMK2D MEF2B KLF4 NKX2-5 ARSENIC METABOLISM AND REACTIVE OXYGEN SPECIES GENERATION%WIKIPATHWAYS_20260810%WP5233%HOMO SAPIENS Arsenic metabolism and reactive oxygen species generation COA3 HEL-S-21 HEL-S-44 UQCRFS1 AS3MT ATP1A1 ND1 SDHA ARACHIDONIC ACID AA ARA OXYLIPIN METABOLISM%WIKIPATHWAYS_20260810%WP5155%HOMO SAPIENS Arachidonic acid AA ARA oxylipin metabolism EPHX2 PTGS1 PTGS2 METABOLISM OF TETRAHYDROCANNABINOL THC %WIKIPATHWAYS_20260810%WP4174%HOMO SAPIENS Metabolism of tetrahydrocannabinol THC CYP2C9 CYP3A4 GNAQ PATHWAYS IN PORT WINE STAIN%WIKIPATHWAYS_20260810%WP5437%HOMO SAPIENS GNAQ pathways in port wine stain NFKB1 YAP1 TRIO MAP2K3 MAP2K1 MAP2K2 ARHA MTOR MAPK1 RAF1 MAP2K5 RAC1 MAP2K4 MAP2K6 MAPK3 AMOT GLYCEROL METABOLISM INCLUDING LINKED IMDS%WIKIPATHWAYS_20260810%WP5570%HOMO SAPIENS Glycerol metabolism including linked IMDs AQP9 G6PC1 HEL-S-162eP MGLL HEL-S-87p PCK1 ENO1 HEL-S-68p GLYCTK PNPLA2 PFKL PC PKLR ALDOB LIPE GPD1 HEL-S-49 KHK AGXT PGAM1 GPD2 FBP1 HEL-S-165mP AQP7 CHOLESTEROL BIOSYNTHESIS PATHWAY%WIKIPATHWAYS_20260810%WP197%HOMO SAPIENS Cholesterol biosynthesis pathway FDPS MVK HMGCS1 MSMO1 IDI1 CYP51A1 SQLE SC5D DHCR7 HMGCR MVD FDFT1 NAD BIOSYNTHESIS II FROM TRYPTOPHAN%WIKIPATHWAYS_20260810%WP2485%HOMO SAPIENS NAD biosynthesis II from tryptophan KMO TDO2 KYNU AFMID NMNAT1 NADSYN1 HEL-S-90n HAAO COPPER METABOLISM%WIKIPATHWAYS_20260810%WP5189%HOMO SAPIENS Copper metabolism SLC31A1 SLC11A2 ATP7B ATP7A MELATONIN METABOLISM AND EFFECTS%WIKIPATHWAYS_20260810%WP3298%HOMO SAPIENS Melatonin metabolism and effects NFKB1 TRAF6 PER2 CYP1A2 PER1 CALM1 CYP2C19 CRY2 SULT1A1 CRY1 ECE1 ACHE IRAK1 AANAT PRKCA MAOA CYP1A1 ASMT CYP1B1 EDN1 GSK3B CAMK2A ADRB1 hCG_2014051 SIRT1 CSNK1D MTNR1A MAP2 PER3 MTNR1B FOXO1 APOE MIR 124 PREDICTED INTERACTIONS WITH CELL CYCLE AND DIFFERENTIATION %WIKIPATHWAYS_20260810%WP3595%HOMO SAPIENS mir 124 predicted interactions with cell cycle and differentiation PTBP1 CTDSP1 SIX4 STRADB STK11 PRKAA1 PSORIASIS MECHANISM AND THERAPIES%WIKIPATHWAYS_20260810%WP5537%HOMO SAPIENS Psoriasis mechanism and therapies IL1B HLA-C IL22 CXCL1 TYK2 CXCL8 IL23R TNF STAT3 CCR6 IL17RC IL17A CCL20 IL23A IL17F IL12RB1 IL12B ENDODERM DIFFERENTIATION%WIKIPATHWAYS_20260810%WP2853%HOMO SAPIENS Endoderm differentiation PAX3 MIXL1 TOX3 STAT1 FOXA1 TCF7L1 FOXA2 NR3C1 SIAH2 DUSP2 SMAD4 ELAVL1 GATA4 HOXC11 FOXO1 HOXA1 MAP2K3 APP WNT8A CER1 NOTCH1 CUL4B ZIC5 BMP7 VAV3 TAF5 WWC1 TCF4 NOG DKK1 NODAL OTX2 POU5F1 CTBP2 PBX1 LEF1 TBX21 SFMBT1 CDYL APC RFX7 RAB38 CTR9 PRDM14 RTF1 WNT3 BPTF FOXN3 SP4 PAF1 TAF4B ONECUT1 CDC73 HHEX DUSP5 Pax9 BTAF1 TCEAL2 LEO1 KDM4A LRPPRC TNRC6C CEBPZ LAMC1 PTHLH CRTC1 CAND1 PLCH1 DUSP4 ACACA SOX7 SOX2 NKX2-1 SOX21 SOX17 TCF2 CEP250 SESN1 WDHD1 FOXH1 SFRP1 GATA6 EMSY PIAS1 NLK WDFY2 BCORL1 TOX MBTD1 EZH2 EPB41L5 MAD2L2 UBR5 ATP8B2 PBX3 GDF3 EXT1 NABP2 TRIM71 BCAR2 PABPC1 PHF6 ZIC3 TRIM5 SMAD2 ZFHX4 C1QBP DNMT3B JARID2 LHX1 SLC2A12 TET1 PARP8 NR1B3 BMPR1A AEBP2 AHDC1 TGFB1 ZNF462 ELP4 RGS10 MACROPHAGE MARKERS%WIKIPATHWAYS_20260810%WP4146%HOMO SAPIENS Macrophage markers CD163 CD83 CD68 CD14 LYZ F3 CD74 PHOTODYNAMIC THERAPY INDUCED NFE2L2 NRF2 SURVIVAL SIGNALING%WIKIPATHWAYS_20260810%WP3612%HOMO SAPIENS Photodynamic therapy induced NFE2L2 NRF2 survival signaling NQO1 ABCC2 EPHX1 MAPK14 HMOX1 HEL-S-22 NQO2 GCLC GCLM ABCG2 MAPK8 CES1 MAPK12 MAPK13 ABCC3 JUN SRXN1 MAPK11 FOS NFE2L2 KEAP1 ABCC6 OXIDATION BY CYTOCHROME P450%WIKIPATHWAYS_20260810%WP43%HOMO SAPIENS Oxidation by cytochrome P450 CYP46A1 CYP1A2 CYP4V2 CYP2C19 CYP7A1 CYP7B1 CYP2C9 CYP2A7 CYP26C1 CYP2F1 CYP2A6 CYP1A1 CYP1B1 CYB5R1 CYP20A1 CYB5R4 CYP4F8 CYP3A4 CYB5R3 CYB5B CYP2A13 CYP51A1 CYP17A1 POR CYP11B2 CYP11A1 CYP26B1 CYP2E1 CYP26A1 CYP3A7 CYP4F3 CYP27A1 CYP2S1 CYP27B1 CYP24A1 CYP2J2 CYP2R1 CYP2B6 CYP3A43 CYP8B1 CYP4Z1 CYP2U1 CYP2W1 CYP4F22 CYP4X1 CYP4F2 CYP4A11 CYP4A22 CYP2C18 CYP4F12 CYP4F11 CYP27C1 HLA C ALLOTYPES INTERACTIONS WITH KIR ON DNK CELLS%WIKIPATHWAYS_20260810%WP5580%HOMO SAPIENS HLA C allotypes interactions with KIR on dNK cells LAT NLRP7 HLA-C NLRP2 KIR2DL1 KIR2DL3 CSF2 TNF TYROBP VAV1 IFNG FYN SYK PLCG1 RAC1 LCP2 PTPN6 ELF3 PRKCA PRKCQ OXIDATIVE DAMAGE RESPONSE%WIKIPATHWAYS_20260810%WP3941%HOMO SAPIENS Oxidative damage response TNFRSF1B NFKB1 TRAF6 CDKN1B APAF1 TNF CDC42 BAK1 CASP3 BAD C1QB MAPK13 C1QA MAPK10 C1S GADD45A TNK2 CDKN1C TRAF1 C1QC NFKBIE BAG4 C3AR1 TRAF2 CR2 C4B_2 PCNA C5AR1 MAP2K4 MAP3K1 BCL2 CYCS CDKN1A CASP9 TRAF3 APOPTOSIS%WIKIPATHWAYS_20260810%WP254%HOMO SAPIENS Apoptosis IGF1 NFKB1 CASP10 TNFRSF1A CRADD APAF1 TP73 BAK1 BIRC5 IRF-1 BAD BAX RIPK1 FADD NFKBIA NFKBIE PRF1 IGF1R HRK CASP4 SCAF11 TNFRSF25 CDKN2A CASP8 TP63 CASP6 CASP2 BOK BCL2L2 BIRC2 BIRC3 IRF2 DIABLO CASP9 IRF3 TRAF3 TNFRSF1B IGF2 DFFB DFFA IRF7 BCL2L1 TNF BBC3 RELA CASP3 PIK3R1 BCL2L11 TNFSF10 PMAIP1 MAPK10 MCL1 JUN TNFRSF10B HELLS TRAF1 TNFRSF21 MDM2 MYC TRADD IKBKB IRF4 TRAF2 IKBKG BNIP3L MAP2K4 LTA IRF6 MAP3K1 TNFSF6 CHUK BCL2 CYCS NFKBIB ANDROGEN RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP138%HOMO SAPIENS Androgen receptor signaling PSMC3IP TGFB1I1 CDC42 STAT3 KDM1A CARM1 PTEN RUNX2 TGIF1 NR2C2 SP1 FLNA UBE3A EGFR RAN EFCAB6 CCND1 HEL32 KAT7 NCOA1 PIAS2 ZNF318 FKBP4 HDAC1 RNF6 CREBBP RNF4 SMAD4 BAG1 CREB1 PATZ1 NR0B2 KAT5 FOXO1 RHOB RB1 KAT2B TLE5 SRC HEL-S-99n UBE2I RELA PIAS1 PIK3R2 PIK3R1 ZMIZ1 CCNE1 STUB1 RAC1 JUN SIN3A RLN1 SMIM40 NCOR1 ROCK1 GSK3B MDM2 ROCK2 EP300 RAD9A ARHA NCOR2 LIMK2 SIRT1 PAK6 FHL2 SUMO1 SMARCE1 ETV5 HEL-S-67p G1 TO S CELL CYCLE CONTROL%WIKIPATHWAYS_20260810%WP45%HOMO SAPIENS G1 to S cell cycle control PRIM1 CDK7 E2F2 CREB3 MYT1 ATF6B CCNB1 POLA2 POLE2 TFDP1 CCNG2 TFDP2 CDKN2D CDKN2B CCND1 CDKN2C MCM7 CDC45 ORC1L CDKN2A ORC6 ORC3 ORC2 PCNA CREB1 MCM3 MCM5 MCM6 RB1 CDKN1B CCND3 CCND2 RPA1 E2F3 RPA3 CCNE2 CCNE1 CCNH GADD45A MCM2 CDKN1C CDC2 CDK6 CDK4 MNAT1 CDK2 CREB3L3 MDM2 CREB3L4 MYC POLE ATM WEE1 CDKN1A PRIM2 MITOCHONDRIAL LONG CHAIN FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260810%WP368%HOMO SAPIENS Mitochondrial long chain fatty acid beta oxidation ACADL EHHADH CPT1A ACSL3 PECR ACSL1 FACL4 ACADM ACADVL ACSF2 ACADS SLC25A20 CPT2 FAMILIAL HYPERLIPIDEMIA TYPE 2%WIKIPATHWAYS_20260810%WP5109%HOMO SAPIENS Familial hyperlipidemia type 2 APOB EPHX2 LDLR APOA4 PLTP GPIHBP1 GHR USF1 APOA2 PCSK9 LPL LIPC VITAMIN B12 METABOLISM%WIKIPATHWAYS_20260810%WP1533%HOMO SAPIENS Vitamin B12 metabolism APOB IL1B LDLR NFKB1 TNF SERPINA3 SAA4 RELA CCL5 SAA1 FGA SAA2 CCL2 IFNG PLAT PLG HEL-S-78p HEL-S-51e F7 INS CBS NFKB2 MTRR HEL-S-44 CTH MPO CRP CUBN F2 ALB TCN2 CBLIF TCN1 ABCA1 SCARB1 MTR IL6 INSR HBB MCEE HBA2 MAT1A APOE ANDROGEN RECEPTOR NETWORK IN PROSTATE CANCER%WIKIPATHWAYS_20260810%WP2263%HOMO SAPIENS Androgen receptor network in prostate cancer STAT1 PAK1 STAT3 FOXA1 JAK1 SPRY2 SP1 CCND1 RAP1A CASP9 MAP2K1 RHEB MAP2K2 TSC2 TSC1 MTOR EIF4EBP1 HSD17B1 MAPK1 RAF1 HSD17B2 HSD17B4 CDC25B F13B HSD17B7 CPN1 BLM MAPK3 RICTOR NOXA1 RPTOR MYC HGF ACTL6B KLK3 BCL2 GRB2 CDKN1A SPRY1 ACTL6A HRAS SOS1 BAD PTEN BAX MSH2 ARID1A PLK1 RAPGEF1 DOCK1 CRKL EIF4E1B ATF1 CDKN2B FKBP5 CDKN2A CASP8 HSD3B2 HSD3B1 HSD17B3 CYP17A1 FOS SPINK1 BARD1 ERG RB1 CDKN1B ETV4 CHEK2 CHEK1 MSH6 CASP3 PTK2B PRKDC SMARCA4 JUN MRE11A PTPN11 CDC2 MAPK14 RAD50 CDK4 SMAD2 CDK2 MDM2 ATM ATR SMARCD1 MAPK8 SMARCD2 SMARCD3 CRK PXN SMARCC1 MAP4K1 SMARCC2 ARID1B TYPE II DIABETES MELLITUS%WIKIPATHWAYS_20260810%WP1584%HOMO SAPIENS Type II diabetes mellitus SURF1 PRKCZ INS-IGF2 SLC2A2 TNF IKBKB PDX1 MAPK8 MTOR MAPK1 PIK3R5 CACNA1A INSR PHKA2 MAFA IRS1 SLC2A4 SOCS4 NUCLEAR RECEPTORS IN LIPID METABOLISM AND TOXICITY%WIKIPATHWAYS_20260810%WP299%HOMO SAPIENS Nuclear receptors in lipid metabolism and toxicity CYP1A2 CYP2E1 CYP26A1 NR1H3 ABCB11 CYP7A1 ABCG5 ABCG1 CYP2C9 NR1i1 CYP27B1 NR1i2 ABCD3 NR1C1 CYP24A1 NR1C2 ABCC3 CYP2B6 ABCC2 CYP8B1 NR1I3 CYP3A4 NR1B3 ABCB4 CYP4A11 NR1H4 RARB PPARG ABCA1 RARA ABCB1 ABCD2 8Q11 23 RB1CC1 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5412%HOMO SAPIENS 8q11 23 RB1CC1 copy number variation RB1 ATG101 GABARAP ATG16L1 TNF TRAF2 PTK2B ULK1 RB1CC1 MAP3K5 GABARAPL2 GABARAPL1 WDR45B PROLINE AND HYDROXYPROLINE PATHWAYS%WIKIPATHWAYS_20260810%WP5026%HOMO SAPIENS Proline and hydroxyproline pathways PRODH OCTADECANOID FORMATION FROM LINOLEIC ACID%WIKIPATHWAYS_20260810%WP5324%HOMO SAPIENS Octadecanoid formation from linoleic acid EPHX3 ALOX12B CYP2C9 CYP4A11 CYP1A2 ALOXE3 PTGS1 CYP3A4 CYP2C19 PTGS2 GPX4 ALOX15 MITOCHONDRIAL FATTY ACID OXIDATION DISORDERS%WIKIPATHWAYS_20260810%WP5123%HOMO SAPIENS Mitochondrial fatty acid oxidation disorders SLC22A5 ACADL EHHADH CPT1A ACSL3 PECR ACSL1 FACL4 ACADM ACADVL ACSF2 ACADS SLC25A20 HADHB CPT2 REGULATION OF ACTIN CYTOSKELETON%WIKIPATHWAYS_20260810%WP51%HOMO SAPIENS Regulation of actin cytoskeleton FGFR2 CDC42 PAK1 ARPC5 VAV1 EZR CHRM1 RAC3 APC2 FGF3 FGF6 PDGFRA FGF9 F2R FGF23 FGF20 FGF22 FGF17 FGF16 FGF14 CHRM4 EGFR CHRM5 FGF21 FGF18 FGF13 FGF12 GNA13 ARHGEF1 CFL2 MAP2K1 LIMK1 MAP2K2 PIK3CD PIK3R3 PIK3R2 CHRM3 PIK3R1 MAPK1 FGF7 RAF1 CHRM2 MAPK3 PDGFA RASSF7 FGF4 FGF19 FGF8 MAPK6 ROCK1 MAPK4 MOS NCKAP1 ACTG1 ARHA BRAF FGF10 MYL1 MYL3 APC ARHGAP35 MYLK SOS1 SOS2 ACTN1 NRAS PIK3R5 PIK3R4 HEL70 CD14 PIK3C2G STM7 ARHGEF4 PIK3C2B ITGA1 PFN1 PIP4K2A PIP4K2B PIP5K1C DOCK1 RRAS PIP5K1A ARHGEF7 RRAS2 FGFR1 PS1TP5BP1 MYH10 SSH2 SSH3 SSH1 BRK1 PIP5KL1 FGD1 HEL-S-15 WASF1 WASF2 BAIAP2 ABI2 CYFIP2 RAC1 BDKRB2 HEL114 BDKRB1 ROCK2 TMSB4X FGF2 RDX F2 CRK CSK PXN PAK6 WAS PAK4 IQGAP1 EGF GNG12 FGFR4 FGFR3 IDO METABOLIC PATHWAY%WIKIPATHWAYS_20260810%WP5414%HOMO SAPIENS IDO metabolic pathway KMO TDO2 KYAT3 KYNU KYAT1 IFNG IDO2 IDO1 GOT2 AADAT TNF 16P11 2 PROXIMAL DELETION SYNDROME%WIKIPATHWAYS_20260810%WP4949%HOMO SAPIENS 16p11 2 proximal deletion syndrome CCDC6 NFKB1 SPN CCT6B UNC13B PARP4 UNC13A PPP2CA HEL-S-90n TAOK2 BPTF EZR PTEN HEL70 HEL-S-87p HIRIP3 CDIPT NR3C1 HDAC3 CASP8 MLL2 REL PCNA PRRT2 PPP2R5D TRAF6 MAP2K3 SMEK1 DOC2A FAM57B FIMP PAGR1 PPP4R1 PPP4R2 PPP4R4 HEL-S-69 PPP4R3B ASPHD1 TCP1 KCTD13 MAP2K6 ZG16 INO80E MAPK3 MVP GDPD3 HIRA CORO1A TBX6 PPP4C CCT8 CCT7 CCT4 IGBP1 HEL-S-100n C16orf54 CCT6A YPEL3 PAXIP1 KMT2C PPP2R1A TRAF2 PPARG SIAH1 GLUCURONIDATION%WIKIPATHWAYS_20260810%WP698%HOMO SAPIENS Glucuronidation UGT1A1 UGT1A3 UGT1A9 UGDH UGT2A2 UGT2B10 UGT2A1 PGM5 UGT2B15 UGT2B11 UGT1A7 UGT2B17 UGT1A4 UGT1A8 UGT2B7 PGM2 UGT2B28 UGT1A5 UGT1A10 UGT2B4 PGM3 GLP 1 SECRETION FROM INTESTINE TO PORTAL VEIN%WIKIPATHWAYS_20260810%WP5446%HOMO SAPIENS GLP 1 secretion from intestine to portal vein PCSK1 SLC5A1 SLC2A2 GCG HEPATITIS C AND HEPATOCELLULAR CARCINOMA%WIKIPATHWAYS_20260810%WP3646%HOMO SAPIENS Hepatitis C and hepatocellular carcinoma NFKB1 LEF1 TGFBR1 BCL2L1 NOS2 E2F2 HNF1A HEL-117 STAT3 BIRC5 VAV2 SOS1 CASP3 MYOF RAC1 JAK1 JUN MAPK3 RRM2 HIF1A PTPN11 MAPK14 CXCR1 COL4A2 IL6R CXCL8 MYC PTGS2 MAPK8 CCND1 VEGFA SMAD4 FRZB IL6 TGFB1 BIRC3 TNFSF6 GRB2 CDKN1A CASP9 CD44 SLEEP REGULATION%WIKIPATHWAYS_20260810%WP3591%HOMO SAPIENS Sleep regulation DLAT DRD1 DRD3 OXT NLGN1 IL18 BTBD9 CACNA1I HTR2A ADA ADORA2A HEL-S-2 TH OXTR CHRNB2 NPY2R SLC29A1 CRH MRGPRX2 PTGDR NPS UTS2R HCRTR2 IL6 HCRTR1 PER3 MTNR1B FOS GHRH GHRL NPAS2 STAR UTS2 DRD2 HIJACK OF UBIQUITINATION BY SARS COV 2%WIKIPATHWAYS_20260810%WP4860%HOMO SAPIENS Hijack of ubiquitination by SARS CoV 2 ELOC CBFB RBX1 UBA3 NAE1 NANOPARTICLE TRIGGERED AUTOPHAGIC CELL DEATH%WIKIPATHWAYS_20260810%WP2509%HOMO SAPIENS Nanoparticle triggered autophagic cell death UVRAG VMP1 ATG14 ATG16L1 DKFZp686F0183 ULK2 TSC2 TSC1 ATG12 MAP1LC3A ULK1 INSR ATG3 BCL2 SH3GLB1 ATG10 INS ATG9B AMBRA1 CHAF1A FBXL10 ENHANCEMENT OF MAP ERK SIGNALING IN DIFFUSE LARGE B CELL LYMPHOMA%WIKIPATHWAYS_20260810%WP4553%HOMO SAPIENS FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma H2AX EED H3C15 H2AB1 BCL6 H2AZ1 H2AB3 H2AZ2 PCGF1 H3C8 RNF2 MAPK1 EZH2 MACROH2A2 H2AJ SUZ12 MAPK3 H3F3B BCOR CAFFEINE AND THEOBROMINE METABOLISM%WIKIPATHWAYS_20260810%WP3633%HOMO SAPIENS Caffeine and theobromine metabolism CYP2A6 CYP1A2 NAT2 XDH PATHOGENESIS OF SARS COV 2 MEDIATED BY NSP9 NSP10 COMPLEX%WIKIPATHWAYS_20260810%WP4884%HOMO SAPIENS Pathogenesis of SARS CoV 2 mediated by nsp9 nsp10 complex MMP25 HLA-DRB5 HLA-DRB1 CRP CXCL8 CD3G NRF CD3E PRG3 CD2 CD8B LBP ZAP70 CD8A FYN IL6 LCK IGLL1 FAMILIAL HYPERLIPIDEMIA TYPE 4%WIKIPATHWAYS_20260810%WP5111%HOMO SAPIENS Familial hyperlipidemia type 4 SEL1L LDLR APOA4 PLTP APOA5 GCKR GPIHBP1 LMF1 ACSS1 GCK PDIA2 MTTP DGAT2 APOA2 LPL LIPC APOC2 WNT SIGNALING IN ADULT HIPPOCAMPAL NEUROGENESIS%WIKIPATHWAYS_20260810%WP5536%HOMO SAPIENS Wnt signaling in adult hippocampal neurogenesis NEUROG2 PROX1 FZD3 NEUROD1 LRP6 WNT7A WNT3A WNT3 CCND1 FZD1 MINERALOCORTICOID BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP5279%HOMO SAPIENS Mineralocorticoid biosynthesis AKR1D1 AKR1C2 AKR1C4 SRD5A2 HSD11B1 HSD11B2 UGT1A10 CYP11B2 CYP21A2 UGT2B7 AKR1C1 GLYCOSAMINOGLYCAN SYNTHESIS IN FIBROBLASTS%WIKIPATHWAYS_20260810%WP5395%HOMO SAPIENS Glycosaminoglycan synthesis in fibroblasts HS2ST1 HS3ST3B1 CSGALNACT1 CHST7 B3GAT3 XYLT2 XYLT1 CHSY1 CHST1 CHST3 B3GALT6 EXT1 EXT2 HS3ST1 HS6ST1 HS6ST2 HS6ST3 NDST3 HS3ST3A1 CHPF EXTL2 CHST12 EXTL1 CHSY3 CHST13 CHST14 CHPF2 CHST11 B3GAT2 GLCE HS3ST2 B3GAT1 CSGALNACT2 UST NUCLEOSOME REMODELING COMPLEX%WIKIPATHWAYS_20260810%WP5572%HOMO SAPIENS Nucleosome remodeling complex RBBP4 HIST1H4L SMIM40 XRCC5 HAT1 CHEK2 ASF1A PRKDC PCNA SUPT16H SSRP1 ASF1B NASP MCM2 CHAF1B H4C9 CHAF1A AFFECTED PATHWAYS IN DUCHENNE MUSCULAR DYSTROPHY%WIKIPATHWAYS_20260810%WP5356%HOMO SAPIENS Affected pathways in Duchenne muscular dystrophy NFKB1 TGFBR1 MMP9 TGFBR2 DMD FGA ELANE CAPN3 SSPN HEL-S-78p NFKBIA FKBP1A PRKAA2 PPIF NOX4 ATP2A1 MMP2 ITPR2 STIM1 SMAD4 CACNA1F opn CACNA1S CASP9 IL1B ORAI1 SLC25A5 SGCA CACNA2D1 PRKAA1 NOS2 TNF CACNB1 CTGF CYBB CACNG1 TRPC1 IL10 AGTR1 TRPC3 IL1A MPO DAG1 SMAD2 CAMK2D TRPC6 RYR1 PRG3 CASQ1 TNNI1 SLN IL6 TGFB1 MCUB TOMM20 SCX TRDN PLA2G2A SNTB1 MAMMARY GLAND DEVELOPMENT PUBERTY STAGE 2 OF 4%WIKIPATHWAYS_20260810%WP2814%HOMO SAPIENS Mammary gland development puberty stage 2 of 4 ERBB2 HEL113 PGR MYC AREG EGF FOSL1 TIMP1 CCND1 TRANSCRIPTION ACTIVATION RNA POLYMERASE I AND KAT2A B AND INHIBITION NURD COMPLEX %WIKIPATHWAYS_20260810%WP5565%HOMO SAPIENS Transcription activation RNA polymerase I and KAT2A B and inhibition NuRD complex PWWP2A RRN3 TAF1D GATAD2A CDK2AP1 H2AC19 H2AB1 H2AC14 H2BC26 H2BC12L H2BC21 ASF1A HIST1H2AB H3C8 H2AC6 H2BC9 H2BC17 KAT2A SRCAP H2BC13 H2AJ H2BC14 H2BC15 H2BC11 HIST1H2BE H3C15 H2AZ1 H2AZ2 HDAC2 H2BC8 H2BC3 H2BC1 HDAC1 CREBBP H2AC20 CHD3 H2AX KAT2B GATAD2B HAT1 MTA2 EP400 TLK2 MAPK3 H2BC12 TBP MBD2 TAF12 H4C9 RBBP4 HIST1H4L CHD4 MBD3 TAF1B EP300 SIRT7 POLR1A POLR1C POLR1D ASF1B UBTF H3F3B PWWP2B APOPTOSIS MODULATION AND SIGNALING%WIKIPATHWAYS_20260810%WP1772%HOMO SAPIENS Apoptosis modulation and signaling AIFM2 MADD NFKB1 CASP10 TNFRSF1A CRADD TNFRSF6B TNFRSF10A PTRH2 PRKD1 APAF1 IL1R1 TNFRSF10C MAP3K14 BAK1 IL1R2 BIRC5 BLK BAD IRAK1 BAX RIPK1 PTPN13 FADD NFKBIA MYD88 BCL2L10 TNFRSF10D BIK HRK CASP4 BCL2A1 TNFRSF25 CDKN2A CASP8 AIFM1 CASP6 CASP2 BOK BCL2L2 BIRC2 BIRC3 FOS DIABLO CASP9 TRAF3 TNFRSF1B TRAF6 DFFB DFFA BCL2L1 PIDD1 BBC3 SEPTIN4 CASP3 NAIP BCL2L11 TNFSF10 PMAIP1 BMF MAP3K5 MCL1 JUN MAPK3 BAG3 TNFRSF10B HTRA2 SMIM40 TRADD IKBKB MAPK8 BNIP3 BIRC7 TNFSF6 BCL2 CYCS HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES MAPK SIGNALING%WIKIPATHWAYS_20260810%WP4877%HOMO SAPIENS Host pathogen interaction of human coronaviruses MAPK signaling BST2 MAP2K3 MAP2K1 IFI27 MAP3K10 MAP2K2 MAPK9 MAPK1 DDIT3 MAPK12 RAF1 EIF4E MAPK13 MAPK10 MAP3K11 IFITM3 JUNB MAP2K6 IFITM1 JUN MAPK11 MAPK3 IFITM2 MAPK14 RPS6KA2 RPS6KA1 ATF2 MAPK8 MAP2K4 MAP3K1 FOS BCL2 CAMKK2 PATHWAY%WIKIPATHWAYS_20260810%WP4874%HOMO SAPIENS CAMKK2 pathway FIS1 CALM1 MS4A3 IFGGE OASL ERMAP PAK1 GALNT9 MAMDC2 HMBS MID1 FASN ERAF SPINT1 SQSTM1 CRTC2 SFI1 ATP10D TSPAN33 RHD HFE ENHO SLC25A21 SLC38A5 WFS1 TMEM176B EPOR TRPV4 SPIRE1 RHAG IL15 PFKFB2 DGIC CXCL11 CAMKK2 CYB5R3 GCK FAM20C SELL CCND1 ARHGEF7 STIM1 ACACA AQP1 CREB1 TBXT TSPAN8 SLC2A4 HMOX1 C1QTNF12 NLRP1 WDR35 ASNS TNF S100A8 CAMK4 TSC1 RELA SMC1A CHRM3 CCL5 KDR MTOR MAP1LC3A CCNE1 MAPK1 RAF1 RAC1 MAPK3 VCAM1 NFE2L2 KEAP1 DKFZp762B153 HIF1A PCK2 RPTOR ATP1B2 PARP1 RPS6 RPS6KB1 EP300 CPOX MAF CAMK1 SIRT1 ABCA1 MX2 ULK1 SLCO3A1 KLF1 HK2 NFATC2 OMEGA 3 FATTY ACIDS IN SENESCENCE%WIKIPATHWAYS_20260810%WP5432%HOMO SAPIENS Omega 3 fatty acids in senescence ELOVL2 HEL-S-22 CYP1A2 PTGS1 CYP2E1 CYP3A4 FPR2 HPGD PTGIS PTGS2 FADS2 ALOX15 ALOX12 ALOX5 EPHX2 LTC4S CYP2C9 FADS1 GPR32 ALOX15B PTGES GSTM4 ELOVL5 NEPHROTIC SYNDROME%WIKIPATHWAYS_20260810%WP4758%HOMO SAPIENS Nephrotic syndrome NPHS1 NPHS2 COQ2 WT1 ITGB4 ALG1 E2F3 COQ6 LAMB2 GPC5 APOL1 SCARB2 YARS SMARCAL1 ARHGAP24 PTPRO COQ8B EMP2 HEL-S-47e SYNPO TRPC6 ZMPSTE24 CUBN ACTN4 LMNA PAX2 CTLA4 CD2AP INF2 COL4A4 PLCE1 COL4A3 COL4A5 MYH9 LMX1B CD151 CYP11B2 WDR73 MYO1E AMINO ACID METABOLISM IN TRIPLE NEGATIVE BREAST CANCER CELLS%WIKIPATHWAYS_20260810%WP5213%HOMO SAPIENS Amino acid metabolism in triple negative breast cancer cells SLC7A11 PSAT1 PHGDH PSPH GLS KILLER CELL IMMUNOGLOBULIN LIKE RECEPTORS AND HUMAN LEUKOCYTE ANTIGEN C PATHWAY%WIKIPATHWAYS_20260810%WP5576%HOMO SAPIENS Killer cell immunoglobulin like receptors and human leukocyte antigen C pathway LAT HLA-C CD34 HRAS KIR2DL1 KIR2DL3 CSF2 TNF TYROBP VAV1 IFNG FYN SYK PLCG1 RAC1 LCP2 PTPN6 GRB2 PRKCA PRKCQ HEPATOCYTE GROWTH FACTOR RECEPTOR SIGNALING%WIKIPATHWAYS_20260810%WP313%HOMO SAPIENS Hepatocyte growth factor receptor signaling SRC HRAS MAP2K1 MAP2K2 PAK1 STAT3 SOS1 PTK2B MAPK1 RAF1 PTEN JUN MAPK3 PTPN11 ITGB1 ITGA1 RAPGEF1 DOCK1 CRKL HGF PTGS2 MAPK8 RAP1A CRK PXN MAP4K1 FOS GRB2 SUZETRIGINE MECHANISM FOR PAIN RELIEF%WIKIPATHWAYS_20260810%WP5558%HOMO SAPIENS Suzetrigine mechanism for pain relief SCN10A TGF BETA SIGNALING IN THYROID CELLS FOR EPITHELIAL MESENCHYMAL TRANSITION%WIKIPATHWAYS_20260810%WP3859%HOMO SAPIENS TGF beta signaling in thyroid cells for epithelial mesenchymal transition CDH6 HEL113 ID1 SNAI1 SMAD2 AKT3 CDH2 CDH16 MAPK1 SMAD4 TNC SNAI2 MAPK3 RUNX2 GASTRIC CANCER NETWORK 2%WIKIPATHWAYS_20260810%WP2363%HOMO SAPIENS Gastric cancer network 2 AHCTF1 RFC3 RFC4 LBR UBE2T SNURF CEBPZ DGIC S100A6 DSCC1 CHTF8 BRIX1 CHTF18 ATAD2 CACYBP FAM91A1 RNF144B RAD17 MYC CD48 EGFR LMNB2 COL9A1 COL9A3 TOP2A OTUD5 UBE2C MTDH VEGFA VEGFR2 SIGNALING%WIKIPATHWAYS_20260810%WP3888%HOMO SAPIENS VEGFA VEGFR2 signaling ACOT9 PSMD4 NFKB1 PRKD1 P4HA2 STAT1 CDC42 PAK1 STAT3 VAV2 PNP TUBA1C TXNIP EZR DKFZp686L0365 FBXW11 NCL ENG ADAM9 TUBB8 VPS39 TBCA ADRB2 MOV10 CCND1 CCRL2 SIAH2 PTPN1 CREBBP ARF4 TPM3 FXR2 CREB1 SH3BGRL3 FOXO1 CYR61 PTMA BCL2L1 EIF4G1 CACNA2D1 HEL-S-99n SET DPM1 ERN1 DNAJB9 MYO6 EIF2A HEL2 MAPKAP1 TMSB10 RICTOR HEL-S-162eP RPS6KA5 MEF2C RPS6 RPS6KB1 DKK1 FOXO3A VEGFA GATA2 RAB4A RAB11A SYNJ1 NRP2 CNP HEL-S-68p SLC8A1 FGA DUSP5 F3 FADD HEL-S-78p EPRS1 HMGB1 FARSB NFKBIA PFN1 SHC2 MAPKAPK5 HEL-S-87p FOXO4 INPP4B OCRL BRD4 ABCF2 CXCL8 EGR1 TNFRSF25 MYO1C NOX4 RAB5A ALB MAPKAPK2 MLST8 HEL107 FHOD1 ARF6 FLII WASF1 RELA MAPK9 MAPK12 TRPC1 AMOT PTPN6 CCT7 CSRP2 TRPC3 MDM2 ROCK2 SHB TMSB4X FRS2 SRPK1 MMP14 EPHA2 CRK CTNNA1 PXN IQGAP1 LMAN1 BMX RCAN1 SRP54 HBD PRKD2 TNFRSF10C HEL-S-133P GLUD1 TAOK2 GPX1 PPM1G ELOC NUMB BMP2 SPIRE1 AKT1S1 ITGB3 ITGAV MMP10 hEMMPRIN PRKAA2 LUC7L UBAP2L CHAC1 PTGS2 IER5 TMEM170A RAP1A SND1 KATNAL2 MMP2 EWSR1 BIN1 ATP6V0D1 GIGYF2 DECR1 DHX36 PLCG1 MICAL2 PRRC2C LARP7 DHX29 KCNC3 CCDC124 EEA1 ELOA CLIC1 CGNL1 SSR4 SSR3 RPL5 FJX1 KANK1 CRIP2 SLC7A1 GPC1 APOLD1 FGD5 MAP2K3 COPG1 MAP2K1 PLOD3 PRKAA1 LIMK1 MAP2K2 TMOD3 RPL13a RPL10A SEMA6D ARMCX1 RAB37 ZNF555 RPL7 PIK3R2 DSC1 PIK3R1 LRRC59 NOTCH4 HTRA1 HEL164 ACKR3 ZC3H15 MTOR HEL-S-94n HEL-S-84 MAPK1 RAF1 TFCP2 CDC42BPB RPL18A GRSF1 DLL4 EIF4E C15orf39 MAP2K6 BMP10 MAP3K5 NRARP RND1 MAPK3 RPLP2 HBEGF CAPZB LRRFIP2 RPS11 ADAMTS9 AFDN ARHGEF15 SHROOM2 GJA1 MMRN2 S1PR1 HLX DNAJB4 FAM120A SLC25A25 ROCK1 PDE4DIP FMNL3 PTPN9 ANXA1 TEAD4 CTNND1 RPL27 EIF3S3 RPL26 PRKCB PLCB3 ATF4 ARHA ACTG1 PRKCI EIF3F NFATC1 ITCH EIF3D PRKCE TMOD1 PSMD11 QK3 BCL2 CYCS GRB2 HEL-S-128m MYL2 SARS1 TFAM TXN PRKCZ TRAF3IP2 AP2A1 HRAS AAG1 SLC2A14 PPP2CA AP2S1 BIRC5 NR4A3 TPP1 FUT1 ITGB1 XB FLT1 CAMKK2 RAPGEF1 ADAM10 EPHB2 FLNB IGFBP7 KL HEL-S-102 HDAC5 ATF2 DOK1 SHC1 ACACA HDAC1 CALU HDAC7 ATP6V1E1 FAF1 ERG tal-1 SRC SDF2L1 NCF1 HEL-S-15 NCF2 HYOU1 CTGF PLA2G5 KDR PTK2B CYBB SDCBP CCL2 HEL-S-2a FYN RAC1 CLTC JUN PRKCA ACACB PTPN11 PABPC1 MAPK14 SELE HEL114 GRB10 HGS GSK3B NCK1 SH2D2A EPN1 PPP3CA PLAUR MAPK8 CBL CSK PRKG1 NAPA FHL2 LDB2 MAP2K4 MYH9 SLC25A11 PDPK1 NFATC2 SODIUM CHANNEL IN EPILEPSY%WIKIPATHWAYS_20260810%WP5598%HOMO SAPIENS Sodium channel in epilepsy MAPK8IP2 CALM1 BACE1 TNF SCN9A SCN10A SCN8A SCN5A FYN NEDD4 SCN4B SCN3A SCN1B SCN2B GSK3B PTPRN SCN11A CAMK2A PDCD10 SCN7A FGF14 SCNM1 SCN1A SCN4A RNF121 WEE1 FGF13 FGF12 PSEN1 PRRT2 SCN2A SCN3B OLIGODENDROCYTE DEVELOPMENT%WIKIPATHWAYS_20260810%WP5574%HOMO SAPIENS Oligodendrocyte development SOX2 SOX9 SOX5 BMP1 OLIG1 OLIG2 SOX10 RELN SOX8 SOX6 NKX2-6 MYT1 ID4 TCF7L2 WNT10A MBP PDGFRA NKX6-1 PRKCA SHH CSPG4 ASCL1 HES5 FGF2 GIG8 CHD8 MYRF ZEB2 PTN ZNF24 DUSP15 ZNF488 EGR2 LGI1 BMP4 OPALIN SMAD1 TMEM98 CNTN1 ZBTB33 SOX11 NKX2-2 NFATC2 NFIA VITAMIN B6 DEPENDENT AND RESPONSIVE DISORDERS%WIKIPATHWAYS_20260810%WP4228%HOMO SAPIENS Vitamin B6 dependent and responsive disorders PIGV HEL-S-302 ALPL ALPI ALDH7A1 PLPBP HEL-S-1a MARKERS OF KIDNEY CELL LINEAGE%WIKIPATHWAYS_20260810%WP5236%HOMO SAPIENS Markers of kidney cell lineage NPHS1 NPHS2 PBX1 WT1 EGLN3 WNT4 ACTA2 TNC OSR1 RSPO3 RSPO1 DCN PECAM1 SIX1 DKFZp781O1323 EGLN2 SMAD1 NOTCH2 TCF21 FAT4 EMX2 FOXD1 ALDH1A2 EYA1 GDNF TCF2 NTN1 HNF1A SFRP1 KDR FGF7 NOTCH1 EGLN1 EPO BMP7 TLX1 NT5E FGF8 REN HNF4A LHX1 PAX2 SALL1 BMP4 SIX2 AXIN2 KIT CITED1 DACT1 KCTD1 TSHZ3 DES TBX18 VSX2 FATTY ACID BETA OXIDATION%WIKIPATHWAYS_20260810%WP143%HOMO SAPIENS Fatty acid beta oxidation CRAT ACSL3 ACSL1 DLD LIPE ACADM HEL-S-49 ACAT1 CHKB HADHB CPT2 ACADL PNPLA2 CPT1A ECHS1 ACSS2 ACSL6 FACL4 ACSL5 GCDH DECR1 ACADVL ACADS LPL SLC25A20 LIPF LIPC GPD2 DUAL HIJACK MODEL OF VIF IN HIV INFECTION%WIKIPATHWAYS_20260810%WP3300%HOMO SAPIENS Dual hijack model of Vif in HIV infection ELOC CBFB UBB RBX1 CUL5 APOBEC3G RUNX1 NON SMALL CELL LUNG CANCER%WIKIPATHWAYS_20260810%WP4255%HOMO SAPIENS Non small cell lung cancer JAK3 POLK HRAS TGFA RET DDB2 E2F2 BAK1 STAT3 SOS1 SOS2 NRAS BAD BAX RASSF1 KIF5A EGFR CCND1 CDKN2A CASP8 ERBB2 PLCG2 PLCG1 STK4 CASP9 CRABP2 RB1 CRABP1 MAP2K1 MAP2K2 PIK3CD E2F3 HEL-S-61 CASP3 RXRB MAPK1 ALK RAF1 EML4 RXRA MAPK3 GADD45B GADD45A PRKCA RXRG GADD45G CDK6 CDK4 ARAF AKT3 HGF PRKCB STAT5B FOXO3A RARB BRAF FHIT EGF CYCS PDPK1 GRB2 CDKN1A 13Q12 12 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5406%HOMO SAPIENS 13q12 12 copy number variation C1QTNF9 ATXN1 SGCD TNFRSF19 SGCA C1QTNF9B SGCB SPATA13 SGCG CDC42 LINGO1 DMD MAPK9 MIPEP RTN4R SACS RAC1 SNTA1 SSPN TRAF5 TRAF1 RTN4 DAG1 MAPK8 TRAF2 ARHA SNTB1 TRAF3 LIPID METABOLISM IN SENESCENT CELLS%WIKIPATHWAYS_20260810%WP5149%HOMO SAPIENS Lipid metabolism in senescent cells PLA2G2D PLA2G3 SLCO2A1 HRAS PTGS2 ALOX5 PLA2G12A PLA2G5 PLA2G4F PLA2G6 PLA2G7 PLA2G12B PLA2G4D PLA2G4E PLA2G4C PLA2G1B PLA2G10 CDKN1A NICOTINE EFFECT ON DOPAMINERGIC NEURONS%WIKIPATHWAYS_20260810%WP1602%HOMO SAPIENS Nicotine effect on dopaminergic neurons DDC SLC18A2 CHRNB2 PPP1R1B CDK5 DRD3 KCNK9 DRD4 CHRNA5 CHRNA6 KCNK3 CHRNA3 GNB1 DRD2 GNAI1 GNG2 TH HUNGER AND SATIETY%WIKIPATHWAYS_20260810%WP5445%HOMO SAPIENS Hunger and satiety POMC LEP MC4R PYY NPY GHRL GCG AgRP CYTOKINE CYTOKINE RECEPTOR INTERACTION%WIKIPATHWAYS_20260810%WP5473%HOMO SAPIENS Cytokine cytokine receptor interaction TGFBR1 TNFRSF1A IL1R1 CCL11 CCR7 IL20RA CCR6 CCR4 CXCR4 IL19 IL20RB CSF3R IL4 TNLG7C IL1RL2 CSF2RB PRL CCL23 TNFRSF11A CNTFR CX3CL1 MPL IL27RA IL15RA ANP32B IL7R IL9R CSF2RA IFNLR1 IL22RA1 PRLR TNLG7A TSLP IL3RA TNFRSF9 ACVR1 LIF CSF1R CNTF CSF1 EPO IL1RN MSTN CCR5 INHA CX3CR1 TNLG5A TPO CXCR1 TNFSF11 BMP6 ACVR2B BMP5 IL6R BMP3 IL11 LEP IL23R IL1RL1 ACKR4 INHBA ACVR1B GDF5 BMP4 IL23A IL3 IL6 LTA NODAL CCL19 IL12RB1 CCL28 IL18R1 IFNAR2 TNFRSF10A IFNAR1 IL13 IL7 INHBB TNLG1B NGF IL15 LTBR CXCL11 IL8RB CD40 CXCL9 CXCL8 IFNA2 TNFRSF25 GDF15 CCL20 TNFRSF4 IL17F IL17D TNFRSF18 IL17C IL17B ACVRL1 IL5RA IL2RG TNFRSF1B IL5 IL2RA IL2RB CXCL12 TNLG2B TNFRSF13B CCL5 TNFRSF14 CCL4 CCL3 IFNB1 IFNG GDF3 TNFRSF10B TNFRSF13C IL22 CXCL13 IL-21 IFNL2 CXCR5 IFNL1 IFNL3 CCL21 CXCR6 CXCL3 AMH IL17RC IL17A IL17RA NGFR ACVR2A CCL4L2 TNFRSF12A TNFSF12 CD27 TNFRSF10C CXCL17 CXCL14 CXCL16 IL36A IL36B GHR IFNGR1 CCL14 IL36RN IFNGR2 IL13RA1 IL36G CCL13 EPOR PPBP GH1 IFNW1 IL1F10 IL9 TNFRSF11B CXCL6 IL20 BMP15 IL26 IL24 CCL8 IL27 CCL7 PF4V1 XCL2 XCL1 CCL1 CCL25 CCL18 CCL24 IL31 CCL22 CSF2 IL37 LEPR CCL27 CCL15 CCL26 CXCL2 AMHR2 IL2 CD40LG IL18 ACKR3 TNFSF10 EDAR BMP10 BMP7 CCR3 CCR2 IL34 TNFRSF21 GDF11 TNFSF6 GHB2 TNFRSF19 IL18RAP IL17RB IL21R TNFSF14 GDF1 TGFBR2 GDF6 RELT IL1R2 GDF10 BMP8B CLCF1 TNLG8A TNFRSF8 IL13RA2 TNFRSF17 INHBC INHBE ACVR1C IL33 CSF3 gdf7 CXCL1 CXCL5 CCR8 LTB IL11RA IL6ST IL10RB IL10RA TNF CCL2 IL10 PF4 IL1A BMPR1A IFNK CCR10 TGFB1 CCR1 XCR1 SPHINGOLIPID PATHWAY%WIKIPATHWAYS_20260810%WP1422%HOMO SAPIENS Sphingolipid pathway ASAH2 CERS3 CERS6 CERK SGMS1 PPP2CA SGMS2 SGPP2 GBA2 CERS5 UGT8 UGCG SGPL1 SPTLC2 KDSR CERS2 ACER1 SPTLC3 SERINC1 SPHK2 CERT1 SPHK1 SPTLC1 PLPP1 HEDGEHOG SIGNALING%WIKIPATHWAYS_20260810%WP4249%HOMO SAPIENS Hedgehog signaling CDON CCND2 ADRBK1 CSNK1A1L IHH GAS1 DHH SPOP DKFZp686L0365 EVC KIF3A CSNK1G3 FBXL17 HHIP SPOPL SMURF2 CSNK1A1 CSNK1G2 SUFU SMURF1 PTCH2 SHH KIF7 CSNK1G1 SMO EVC2 hCG_2014051 CCND1 GPR161 PRKACG CSNK1D GLI3 PTCH1 BCL2 BOC WNT BETA CATENIN SIGNALING IN LEUKEMIA%WIKIPATHWAYS_20260810%WP3658%HOMO SAPIENS Wnt beta catenin signaling in leukemia ZBTB16 LEF1 SALL4 LRP5 WNT1 LRP6 GSK3B APC MYC CCND1 TCF3 DKK1 FLT3 WIF1 NR1C2 AXIN2 RUNX1T1 PYGO1 RARA PML JUP CSNK1A1 BCL9 VASOPRESSIN REGULATED WATER REABSORPTION%WIKIPATHWAYS_20260810%WP5085%HOMO SAPIENS Vasopressin regulated water reabsorption ADCY3 ARHGDIB DYNC1H1 RAB11A ADCY6 DYNLL2 DYNC2LI1 DYNC1LI1 DYNC1LI2 CREB3 RAB11B DCTN6 DCTN1 DNCL1 CREB5 DCTN4 DYNC1I1 ADCY9 AVPR2 STX4A AQP4 AVP RAB5B AQP2 AQP3 RAB5C VAMP2 DCTN5 HEL-S-47e HEL-S-77 CREB3L3 CREB3L4 CREB3L2 RAB5A PRKACG GNAS CREB1 ARHGDIG DYNC2H1 BMP SIGNALING IN EYELID DEVELOPMENT%WIKIPATHWAYS_20260810%WP3927%HOMO SAPIENS BMP signaling in eyelid development SHH TGFA DKK2 FGFR2 DKFZp781O1323 PITX2 EGFR SFRP1 MAPK9 BMP4 SMAD4 SMAD1 JUN MAP3K1 NOTCH1 FOXC2 MAPK3 FOXC1 INHBB FGF10 BIOGENIC AMINE SYNTHESIS%WIKIPATHWAYS_20260810%WP550%HOMO SAPIENS Biogenic amine synthesis MAOA PAH ASMT DDC DBH TPH1 GAD1 ACHE HDC GAD2 ChAT PNMT AANAT TH NEUROINFLAMMATION AND GLUTAMATERGIC SIGNALING%WIKIPATHWAYS_20260810%WP5083%HOMO SAPIENS Neuroinflammation and glutamatergic signaling IGF1 NFKB1 DLAT TGFBR1 TNFRSF1A PDHA1 IL1R1 CALM1 PSAT1 PHGDH STAT1 PSPH STAT3 DLD IL4 SLC38A1 JAK1 SLC38A5 IFNGR1 IL13RA1 IFNGR2 SHMT1 HEL-S-51e TGFBR3 CAMK2A SMAD4 SLC2A3 CREB1 CAMK4 LIF MAPK1 CNTF TRAF5 MAPK3 IRS1 GLS GFAP IL6R PRKCB PLCB3 PLCB4 SLC1A3 PLCB1 PLCB2 IL6 LTA BCL2 IL12B BDNF IL12A SLC1A4 CAMK2G SLC6A9 TGFBR2 IL1R2 IL13 DISC1 NGF NFKB2 NELF CAMKK1 SLC38A3 SLC7A10 CAMKK2 LRRC8C LRRC8D LRRC8E GRIN1 DAO PIG59 SLC1A1 SOCS3 SLC1A2 GRIA3 GRIA4 GRIN3B IL6ST GRIN3A FOS GRIK5 GRIK3 IL10RB GRIK1 IL10RA IL1B GRIK2 TNFRSF1B ADCY3 ADCY1 GRIN2B GRM2 GRM8 ADCY8 HEL-S-15 TNF IFNG IL10 PPP1CC PRKCA HEL-S-80p ARC IL1A GRIA2 SMAD2 CAMK2D FGF2 TGFB1 GLS2 INSR SLC17A6 SLC17A7 MIRNA BIOGENESIS%WIKIPATHWAYS_20260810%WP2338%HOMO SAPIENS miRNA biogenesis XPO5 DROSHA DGCR8 RAN TARBP2 DICER1 METASTATIC BRAIN TUMOR%WIKIPATHWAYS_20260810%WP2249%HOMO SAPIENS Metastatic brain tumor PIK3R1 CDK6 MYC CDC42 E2F3 DEVELOPMENT AND HETEROGENEITY OF THE ILC FAMILY%WIKIPATHWAYS_20260810%WP3893%HOMO SAPIENS Development and heterogeneity of the ILC family IL12A IL1B IL5 TBX21 ATL1-beta TNF IL18 HNF1A IL4 IFNG TOX IL13 IL7 IL9 RORA IL15 IL33 ZBTB16 IL22 GFI1 RORC AHR GIG8 IL17A NFIL3 GATA3 IL23A IL6 AREG TSLP IL12B MECP2 AND ASSOCIATED RETT SYNDROME%WIKIPATHWAYS_20260810%WP3584%HOMO SAPIENS MECP2 and associated Rett syndrome IGF1 HNRNPH1 BCL6 CNP CTCF YBX1 MYT1 GAD1 FGF3 PTEN HEL-S-20 SP1 SP3 IGF1R PSIP1 UBE3A RBFOX1 TET3 CAMK2A GPRIN1 DLX6 NREP PRPF38A GRIN1 TAF1 POU4F1 REST FKBP5 SST HNRNPF HDAC1 GRIA3 CREB1 GRIA4 FUT8 IGF2 CDON CEBPD SMC3 SGK1 FUS TARDBP DLX5 MTOR EZH2 MBP TET2 SIN3A FGF4 NCOR1 MEF2C FOXG1 POU3F2 RPS6 OPRK1 FGF2 TET1 NF1 APOC2 BDNF NEOLACTO SERIES SPHINGOLIPID METABOLISM%WIKIPATHWAYS_20260810%WP5302%HOMO SAPIENS Neolacto series sphingolipid metabolism FUT5 B4GALT1 NAGA FUCA1 NEU2 hCG_1998026 SIAT4C B3GNT5 B4GALT4 FUT1 NICOTINE METABOLISM IN LIVER CELLS%WIKIPATHWAYS_20260810%WP1600%HOMO SAPIENS Nicotine metabolism in liver cells CYP2A6 AOX1 UGT1A9 UGT1A4 CYP2B6 STEROIDOGENIC PATHWAY%WIKIPATHWAYS_20260810%WP4463%HOMO SAPIENS Steroidogenic pathway HSD17B1 HSD3B1 CYP17A1 STAR CYP11A1 GLP 1 FROM INTESTINE AND PANCREAS AND ROLE IN GLUCOSE HOMEOSTASIS%WIKIPATHWAYS_20260810%WP5452%HOMO SAPIENS GLP 1 from intestine and pancreas and role in glucose homeostasis PCSK2 PCSK1 GLP1R GCG INS NANOPARTICLE TRIGGERED REGULATED NECROSIS%WIKIPATHWAYS_20260810%WP2513%HOMO SAPIENS Nanoparticle triggered regulated necrosis FTL CASP8 TNFRSF1A RIPK1 RIPK3 PARP1 FADD TRADD TNF TICAM1 MAPK8 NF1 COPY NUMBER VARIATION SYNDROME %WIKIPATHWAYS_20260810%WP5366%HOMO SAPIENS NF1 copy number variation syndrome RAB11A PER1 RBBP7 SYN1 CRY1 EZH1 OMG MYT1 SOS1 RTN4R H3C8 EXOC8 SUPT5H TUBB CCNA2 EXOC2 NGF SDC2 EED H3C15 EGFR HOXA9 POLRMT EXOC4 EXOC3 PCNA EXOC6 EXOC7 EVL EXOC5 EXOC1 INPP5A E2F6 RAB11FIP4 TEFM ARF6 UTP6 HOXA1 ATAD5 COPRS EVI2A CENTA2 MAP3K2 CRLF3 EVI2B METAP2 RFC3 RFC4 LIMK1 RFC2 HEL-S-15 USP1 CCNE2 CCNE1 MAPK1 IFNB1 RAF1 MCL1 SUZ12 MAPK3 H4C9 HIST1H4L WDR48 RAD51 ROCK2 JARID2 RAD9A ATR ARHA NF1 EIF3A NGFR MAVS MAP3K1 BCL2 EGF RIGI INSULIN SIGNALING IN ADIPOCYTES NORMAL CONDITION %WIKIPATHWAYS_20260810%WP3634%HOMO SAPIENS Insulin signaling in adipocytes normal condition MTOR TBC1D4 INSR RPS6 RPS6KB1 IRS1 SLC2A4 MRNA PROTEIN AND METABOLITE INDUCED STRESS PATHWAY BY CYCLOSPORIN A%WIKIPATHWAYS_20260810%WP3953%HOMO SAPIENS mRNA protein and metabolite induced stress pathway by cyclosporin A SLC7A11 ATF4 SLC3A2 SLC7A5 NFE2L2 KEAP1 PEROXIREDOXIN 2 INDUCED OVARIAN FAILURE%WIKIPATHWAYS_20260810%WP4873%HOMO SAPIENS Peroxiredoxin 2 induced ovarian failure CASP3 HSD3B2 HEL-S-2a MAPK10 PARP2 BAX STAR CYP11A1 SEROTONIN RECEPTOR 2 AND ELK SRF GATA4 SIGNALING%WIKIPATHWAYS_20260810%WP732%HOMO SAPIENS Serotonin receptor 2 and ELK SRF GATA4 signaling HTR2A MAPKAPK2 NRAS MAPK1 RAF1 HRAS GATA4 MAP2K1 MAP2K2 MAPK3 RASGRF1 HTR2B LEUCINE ISOLEUCINE AND VALINE METABOLISM%WIKIPATHWAYS_20260810%WP4686%HOMO SAPIENS Leucine isoleucine and valine metabolism HSD17B10 ACAD8 ACADSB ACSF3 DBT MLYCD MCCC2 PCCA ECHS1 MCCC1 DLD PCCB BCAT2 BCAT1 ACAT1 IVD 3Q29 COPY NUMBER VARIATION SYNDROME%WIKIPATHWAYS_20260810%WP4906%HOMO SAPIENS 3q29 copy number variation syndrome NCBP1 HEL-S-71 NCBP2 PIGX PIGM H2BC21 FNDC8 HFE FBXW7 ADAM10 RNF8 RNF168 CEP19 DYNC2H1 DYNC2I2 MCRS1 DYNLT1 DYNLT3 DYNLT2B DYNLL2 DYNC2LI1 NRROS UBXN7 PIK3R3 SMCO1 MFI2 FBXO45 ZDHHC19 DYNLRB2 BRINP1 DNCL1 TM4SF19 CEP350 MAD2L1BP WDR53 ZNF76 JUN MYCBP2 HIF1A SLC51A SLC51B TFRC MYC SLC40A1 NF2 HAMP RABL2B STAT5B SIRT1 PXN TGFB1 TF THERMOGENESIS%WIKIPATHWAYS_20260810%WP4321%HOMO SAPIENS Thermogenesis HRAS ACSL3 CREB3 KDM3A KDM1A SOS1 BMP8B RPS6KA6 SOS2 PRDM16 CREB5 UCP1 NRAS LIPE PLIN1 ADRB3 ARID1A AKT1S1 PRKAA2 PNPLA2 ATF2 CPT1A FGF21 PRKACG ACSL6 FACL4 MLST8 ACSL5 GNAS PPARGC1A CREB1 GCG FGFR1 PS1TP5BP1 ADCY3 ADCY1 ADCY8 ADCY6 MAP2K3 PRKAA1 ADCY5 RHEB HEL-S-7a TSC2 TSC1 ACSL1 PRKAB2 MTOR PRKAG1 PRKAG2 ADCY9 MAPK12 MAPK13 ZNF516 SMARCA4 PRKAB1 KDM3B MAP3K5 SLC25A29 MAPK11 PRKAG3 BMP8A CPT2 MAPK14 RPTOR CPT1C MGLL RPS6KA2 RPS6KA1 CREB3L3 CREB3L4 RPS6 CNR1 CREB3L2 RPS6KB1 RPS6KB2 FRS2 SMARCD1 SMARCD2 ACTG1 SMARCD3 ACTL6B SIRT6 DPF1 DPF3 PRKG1 PPARG SMARCE1 SMARCC1 SMARCC2 ARID1B SLC25A20 GRB2 ACTL6A HEME BIOSYNTHESIS%WIKIPATHWAYS_20260810%WP561%HOMO SAPIENS Heme biosynthesis ALAS1 ALAS2 FECH UROD UROS CPOX HMBS ENDOCHONDRAL OSSIFICATION%WIKIPATHWAYS_20260810%WP474%HOMO SAPIENS Endochondral ossification IGF1 CALM1 CAB39 MMP9 SOX6 STAT1 IHH ENPP1 PLAT GHR KIF3A GH1 RUNX2 PTH PTH1R THRA HMGCS1 PTHLH TIMP3 IGF1R FGF18 MGP opn FGFR1 SCIN SOX9 IGF2 SOX5 COL2A1 BMP7 CDKN1C BMP6 MEF2C ALPL RUNX3 FGF2 ADAMTS4 ADAMTS5 COL10A1 NKX3-2 BMPR1A DDR2 STAT5B CST5 VEGFA ACAN CHST11 FRZB GLI3 TGFB1 PTCH1 FGFR3 RETINOID METABOLISM IN RETINA HEALTHY VS RLBP1 DEFICIENT%WIKIPATHWAYS_20260810%WP5532%HOMO SAPIENS Retinoid metabolism in retina healthy vs RLBP1 deficient RLBP1 MFAP5 EFFECT ON PERMEABILITY AND MOTILITY OF ENDOTHELIAL CELLS VIA CYTOSKELETON REARRANGEMENT%WIKIPATHWAYS_20260810%WP4560%HOMO SAPIENS MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement MYL2 HEL114 MFAP5 MYLK ACTN1 PXN MAPK1 PLCG1 CREB1 JUN MAPK3 LPP TJP1 ITGB3 PRKCQ ITGAV FATTY ACID OMEGA OXIDATION%WIKIPATHWAYS_20260810%WP206%HOMO SAPIENS Fatty acid omega oxidation CYP2A6 CYP1A1 CYP1A2 CYP2E1 CYP3A4 HEL-S-4 ADH1C CYP4A11 HEL-S-117 ADH1A ADH7 ALDH2 HEL-S-53e SPINAL CORD INJURY%WIKIPATHWAYS_20260810%WP2431%HOMO SAPIENS Spinal cord injury IL1R1 CDC42 RTN4R IL4 TNFSF13 RTN4 FKBP1A MMP12 EGFR PTGS2 E2F5 CCND1 CXCL2 IL2 TNLG7A RHOB SOX9 COL2A1 XYLT1 CCNG1 MAPK1 EPHA4 MBP MAPK3 AQP4 GAP43 GFAP GJA1 EFNB2 CCR2 ZFP36 ANXA1 LEP MYC PRB1 PRB2 ARHA FOXO3A IL6 BDNF MMP9 OMG BTG2 CD47 TACR1 AIF1 HEL113 CSPG4 CXCL1 COL4A1 SLIT1 SLIT3 LTB4R CXCL8 EGR1 GRIN1 ROS1 NOX4 LTB AQP1 FOS RB1 IL1B SLIT2 CDKN1B GDNF TLR4 NTN1 NOS2 FCGR2A ARG1 TNF APEX1 CASP3 PLA2G5 PLA2G6 IFNG CCL2 PLXNA2 RAC1 C1QB SELP GADD45A SEMA6A PRKCA PDYN BCAN KLK8 CDC2 NCAN VCAN RGMA LILRB3 IL1A CDK4 CDK2 ROCK2 PPP3CA ACAN CHST11 NGFR TGFB1 PLA2G2A ACUTE VIRAL MYOCARDITIS%WIKIPATHWAYS_20260810%WP4298%HOMO SAPIENS Acute viral myocarditis IL12A MYH6 AAG1 MMP9 STAT1 TICAM1 STAT3 CXCR4 DMD SOS1 RAC3 SOCS1 JAK1 BAX AIF1 NFKB2 ABL2 CCND1 CASP8 CASP6 CASP2 IL2 CD40LG CREB1 NOD2 CASP9 PYCARD PS1TP5BP1 SGCD DFFB SGCA DFFA BCL2L1 SGCB CXADR EIF4G1 SGCG SRC TLR5 TLR4 TLR3 TNF CASP3 PIK3R1 IFNG MAPK1 FYN IL10 MAPK3 CCR5 CCR3 PABPC1 CD55 EDN1 CAAP1 CHRAC1 BNIP2 DAG1 GSK3B MICA PARP1 HEL-S-28 HLA-DMA IL6 TGFB1 BCL2 CYCS CD80 IL12B LIPID PARTICLES COMPOSITION%WIKIPATHWAYS_20260810%WP3601%HOMO SAPIENS Lipid particles composition APOC3 APOB LDLR APOA2 LPL APOC2 APOE FATTY ACID TRANSPORTERS%WIKIPATHWAYS_20260810%WP5061%HOMO SAPIENS Fatty acid transporters HEL-S-104 FABP1 FABP9 FABP5 SLC27A4 FABP6 ACSL3 ACSL1 ACSL6 FACL4 ACSL5 CD36 FABP2 DBI MIR TARGETED GENES IN MUSCLE CELL%WIKIPATHWAYS_20260810%WP2005%HOMO SAPIENS miR targeted genes in muscle cell PDE3A HYAL3 P4HA2 PSAT1 CPNE8 VEZT PWP1 CIAO2A POGLUT3 TDG SLC38A1 RARS1 ATP6V0E1 FNDC3B FNDC3A NCL RAI14 SRSF9 PISD TMED10 MTRR CBFB ADIPOR2 TMEM41B RTN4 BACH1 UBE2J1 GPAM MRPL20 CA12 COMMD9 CHORDC1 ATP6V1C1 ABCG2 CEBPB RAVER2 SEC62 HMGA1 CDIPT VPS39 SLC4A10 CDK5RAP3 TBCA EGFR MBNL1 MOV10 PPIF CARHSP1 CCND1 CHMP2A WDR82 SRPRB ERBB3 ANP32B FAR1 DKFZp761E1322 ERBB2 RNP24 HACD3 PICALM ARF4 TPM3 NRP1 RDH10 TRAM1 GRPEL2 ATP2A2 ADAR MRC2 SNX6 GSTM4 SPTLC1 SH3BGRL3 NFIA CYR61 RAB27B GNA13 NCEH1 CSDE1 SFXN1 PXDN STRN PTMA CACNA2D1 DNAJB1 GFM1 POLR2C ASH2L PPP1R7 BACE1 POLD2 COIL SH3BP4 SERP1 E2F3 MAGT1 TMED3 PDLIM7 DHX15 MPZL1 NELFCD DSG2 SLC12A2 CTSC GALNT7 MRPS24 GALNT1 TMT1A AP3D1 AP3B1 ARCN1 SLC7A6 CDCP1 SPCS3 FRG1 FMNL2 AXL NEDD4 SSNA1 LAMTOR5 NOTCH1 AMIGO2 CSF1 CUL4B NAPG BET1 PGRMC1 IRS1 SRSF10 NT5E SPRYD4 TTC9C ARHG WDR11 TPPP3 SNX15 LAMC2 TUSC2 LTN1 CPOX ARID4B TXN2 ABHD10 ACVR1B KPNA3 ATG9A STX7 UBE4A CDKAL1 KIT HEL-S-66 RAB30 SYPL1 SPARC GPD2 GEMIN7 PPIB SLC1A4 CORO1C CD164 BRPF3 IGF2R GNL3L SLC25A1 DOCK5 CALCOCO2 DOCK7 TNFAIP2 TMEM109 ACP2 SNAP29 SCYL1 HSDL1 ARID1A PLK1 RCN2 RFT1 RBMS1 LUZP1 SNAP23 NUFIP2 PTPRF NXN HEL-S-47e CAND1 IGF2BP1 HES1 ZNF622 SLC25A24 NHERF2 SLC4A7 RQCD1 SLC25A32 TMED7 CSNK1D NOTCH2 RB1 SHOC2 CDKN1B CXCL12 UHRF1 PANX1 USP1 SLC25A13 EZH2 MAPK12 TNFRSF10B CDK6 ITGA2 C1QBP LMNB2 HEL-S-30 GNPNAT1 GFPT1 MYLIP POLE4 POLA2 MTHFD2 SLC38A5 SEC23A CYP51A1 LAMTOR3 RHEB FADS2 PHLDB2 CCNG1 EIF4E MCL1 GJA1 ELMOD2 HSD17B12 HEL-S-273 PKN2 PRKCI HEL-S-108 TPM1 BCL2 LPL CDKN1A YWHAQ EHMT1 TGFBR2 IFRD1 ANAPC1 TP53INP1 LAMC1 CYP1B1 THBS1 COL3A1 CLDN1 COL1A2 TYMS ERG HMOX1 SLC7A11 ITGB4 SYNE2 SYNE1 TMEM43 PTPA SDCBP MAPK14 COL1A1 GRIA2 TMEM87A VSNL1 FSTL1 FGF2 CAMTA1 PPP3CA NF2 MAPK7 HEL-S-303 MYO1E CAFFEINE IN BLOOD VESSELS%WIKIPATHWAYS_20260810%WP5601%HOMO SAPIENS Caffeine in blood vessels PDE4D ADCY3 HEL-S-80p ADCY1 ADCY8 PDE3A PPP1R12C ADCY6 CALM1 ADCY5 RYR2 MYLK ADRA1B ADRA1A RYR3 ADRA1D ADCY9 PDE3B PDE4B ADORA2A PDE4A ADORA2B GUCY1A2 LEPTIN INSULIN SIGNALING OVERLAP%WIKIPATHWAYS_20260810%WP3935%HOMO SAPIENS Leptin insulin signaling overlap LEP STAT3 PIK3R3 LEPR SOCS2 SOCS3 IRS4 SOCS1 INSR PDPK1 IRS1 INS DGKZ INTERFERON MEDIATED SIGNALING%WIKIPATHWAYS_20260810%WP4558%HOMO SAPIENS Interferon mediated signaling IFNAR2 IFNA13 IFNA14 IFNA16 TYK2 IFNA17 STAT1 PIK3R1 IFNAR1 IRF9 IFNA10 IFNB1 IFNG STAT2 JAK1 IFNGR1 IFNGR2 IFNA21 IFNW1 PRKCA IFNA5 IFNA4 IFNA7 IFNL2 IFNL1 IFNL3 IFNA6 IFNA1 IFNL4 IFNA2 IFNA8 IFNLR1 IFNE IFNK IL10RB ANGIOPOIETIN LIKE PROTEIN 8 REGULATORY PATHWAY%WIKIPATHWAYS_20260810%WP3915%HOMO SAPIENS Angiopoietin like protein 8 regulatory pathway PCK1 MAP3K14 NR1H3 FASN IRS4 GSK3A FBP1 THRA SREBF2 PRKAA2 PTPN1 SCD EXOC7 GYS1 FOXO1 MAP3K2 MAP2K3 MAP2K1 MAP3K10 RHEB MAP3K12 PRKAA1 MAP2K2 PIK3CD PIK3R3 TSC2 TSC1 PIK3R2 PIK3R1 PRKAB2 MTOR EIF4EBP1 PRKAG1 PRKAG2 MAPK1 RAF1 EIF4E MAP3K11 RXRA PRKAB1 MAP2K6 MAP3K5 MLXIPL PRKAG3 MAPK3 IRS1 INS MAPKAP1 RICTOR RPTOR RPS6KA4 MAPK6 RPS6KA5 RPS6KA2 MAPK4 RPS6KA1 ANGPTL8 RPS6KB1 RPS6KB2 FOXO3A LPL MAP3K8 G6PC1 HRAS CYP7A1 ABCG8 ABCG5 SOS1 RPS6KA6 SOS2 MAP3K6 PIK3R4 PIK3C2G MAP3K13 HEL-S-31 SHC2 FLOT1 SHC3 FLOT2 CAP1 RAPGEF1 MAP4K2 CYP3A4 MINK1 NR1A2 MAP4K3 HEL-S-42 SHC1 MLST8 SESN3 SLC2A4 MAPK9 MAPK12 MAPK13 MAPK10 MAPK11 CYP2B6 MAPK14 CBLC GSK3B TRIP10 MAPK8 MAPK7 CBL CRK MAP3K7 MAP2K5 MAP4K1 MAP2K4 SLCO1C1 SLC16A2 INSR MAP3K1 PDPK1 CILIARY LANDSCAPE%WIKIPATHWAYS_20260810%WP4352%HOMO SAPIENS Ciliary landscape PSMD7 RANBP10 NFKB1 ZMYND19 MYL6B RPGR RAB8A TMED1 DFNB31 NINL CALM1 RBM14 CNOT6L EIPR1 RAB3IL1 ARFGAP3 NME8 ACSL3 MAPRE2 IFT70A RAB21 BBS4 RMND5B CEP290 DNPEP PGRMC2 SNRPB2 LCN2 EXOC8 VAPB GID8 TRAF3IP1 YPEL5 NUP133 EXOC2 UQCC RAB2A GLB1 CBS POM121 DCAF7 PSMC6 PSMC4 CDR2 NDUFA9 CAMK2A COPS8 PSMD12 MCM7 ECHS1 PSMD13 NUP88 NEFL MCM10 MYL6 IQGAP3 CREBBP MFAP1 EXOC7 MCM3 MCM5 MCM6 TTC26 GLA DYNC2I2 IFT172 DYNC1H1 DYNLT1 IFT140 IFT52 DYNLT3 HEL-S-91n DYNLT2B IFT80 DYNLL2 RAB14 DYNC1LI1 IFT22 BBS9 BBS7 COPS6 IFT43 CEP97 IFT81 IFT27 IFT57 DYNLRB2 BBS5 DNCL1 IFT46 IFT25 LZTFL1 RHBDD2 SSNA1 TFAP2B IFT70B YAP1 GDI1 IFT74 EXOSC4 BBS2 BBS1 NDUFA5 WEE1 FUZ EFHC2 IFT20 TTC8 UBE2D2 H3F3B CLUAP1 PAFAH1B1 CTBP2 RALB APC DVL3 DOCK5 INTU HEL-S-296 SNAP29 NEK8 CEP170 MSH2 LRPPRC HEL113 IQCB1 HEL-S-47e TBC1D4 RQCD1 HDAC2 CCDC40 ANKS3 HDAC1 USH1C EXOC4 EXOC3 EXOC6 EXOC5 EXOC1 MAEA DDX5 RB1 ARMC8 STOM COPS7A COPS4 COPS5 VPS4A BBIP1 WDR26 CD2BP2 RAC1 RMND5A EIF5B RANBP9 TFAP2A MCM2 MKLN1 TFAP2C GID4 HTRA2 NEF3 MKS1 DGKE SMC4 APMAP TIPRL ERF ARL8B CDH23 XPNPEP3 AAR2 IQGAP1 CTSA NUDC UBE2H TFAP2D TFAP2E MCM9 EXOC6B CNOT10 RABEP2 LSM4 EHD3 CNOT1 WNK1 DNA IR DOUBLE STRAND BREAKS AND CELLULAR RESPONSE VIA ATM%WIKIPATHWAYS_20260810%WP3959%HOMO SAPIENS DNA IR double strand breaks and cellular response via ATM H2AX MDC1 TRAF6 TP53BP1 BRCA2 SMC3 TRIM28 APAF1 CHEK2 HSF1 TP73 CHEK1 BAK1 NBN SMC1A CASP3 FANCD2 PRKDC TERF2 BAX BLM RASSF1 MRE11A NABP2 RAD52 RAD50 YAP1 RAD51 CDK5 RNF8 MDM2 RAD17 PARP1 LATS1 ATM RAD9A MCPH1 ATF2 ATR CDKN2A PCNA RIF1 KAT5 CASP9 ACTL6A LINOLEIC ACID METABOLISM AFFECTED BY SARS COV 2%WIKIPATHWAYS_20260810%WP4853%HOMO SAPIENS Linoleic acid metabolism affected by SARS CoV 2 ELOVL2 ACE2 FADS1 FADS2 ELOVL5 SPINA BIFIDA%WIKIPATHWAYS_20260810%WP5150%HOMO SAPIENS Spina bifida MTRR MTHFD1 AHCYL2 MTR DNMT3B SHMT1 MAT1A LTF DANGER SIGNAL RESPONSE PATHWAY%WIKIPATHWAYS_20260810%WP4478%HOMO SAPIENS LTF danger signal response pathway IL1B NFKB1 TRAF6 AGER HEL110 MYD88 IL1A TLR4 CXCL8 TNF IFNA1 TREM1 IFNB1 MAPK1 IL6 IRAK1 IRAK4 CD14 GALANIN RECEPTOR PATHWAY%WIKIPATHWAYS_20260810%WP4970%HOMO SAPIENS Galanin receptor pathway CDKN1B VAMP2 YAP1 CRP BCL2L11 VEGFA PPARG IL6 CREB1 POMC FOS SLC2A4 INS CDKN1A CDKN1C NANOMATERIAL INDUCED INFLAMMASOME ACTIVATION%WIKIPATHWAYS_20260810%WP3890%HOMO SAPIENS Nanomaterial induced inflammasome activation IL1B NFKB1 TLR4 PYCARD DDX1 AS A REGULATORY COMPONENT OF THE DROSHA MICROPROCESSOR%WIKIPATHWAYS_20260810%WP2942%HOMO SAPIENS DDX1 as a regulatory component of the Drosha microprocessor DDX1 RAD50 DROSHA ATM DGCR8 MRE11A NBN CYSTEINE AND METHIONINE CATABOLISM%WIKIPATHWAYS_20260810%WP4504%HOMO SAPIENS Cysteine and methionine catabolism SQOR HEL-S-61p CTH GCLC CDO1 MTR SUOX HEL-S-64p ETHE1 CBS pcap MAT1A NRXN1 DELETION SYNDROME%WIKIPATHWAYS_20260810%WP5398%HOMO SAPIENS NRXN1 deletion syndrome DLG4 GRIN2B NLGN3 GRIA3 GRIA2 NLGN2 GRIA4 GRIN3B NLGN1 GRIN3A GRIN1 NRXN1 10Q22Q23 COPY NUMBER VARIATION%WIKIPATHWAYS_20260810%WP5402%HOMO SAPIENS 10q22q23 copy number variation NFKB1 DNAJB13 GLUD1 STAG1 BUB1B SH2D4B FAM25A ADIRF LDB3 BMP2 GHITM MAS1 CDHR1 DYDC2 RGR GPR15LG SNCG SUSD2 TSPAN14 LRIT2 SHLD3 LRIT1 ADAM10 PRXL2A CEBPA SHLD2 SHLD1 CCSER2 ERBB4 RSPH9 ROPN1L MAT1A RSPH3 RSPH6A RSPH1 DYDC1 PDS5B PDS5A SMC3 ZMYND11 OPN4 RAD21 RSPH14 WAPAL NRG3 IQUB SMC1A NME5 MAD2L2 MMRN2 TNFSF11 SH3GL3 SIRT4 BMPR1A VEGFA PPARG ACTN2 ACE INHIBITOR PATHWAY%WIKIPATHWAYS_20260810%WP554%HOMO SAPIENS ACE inhibitor pathway KNG1 CTSG BDKRB2 NR3C2 AGTR1 BDKRB1 REN AGTR2 CMA1 ACE2 TGFB1 MAS1 CYP11B2 ATP6AP2 MITOCHONDRIAL GENE EXPRESSION%WIKIPATHWAYS_20260810%WP391%HOMO SAPIENS Mitochondrial gene expression SP1 ESRRA TFAM MTERF3 MTERF1 CAMK4 PPP3CA NRF1 GABPB1 POLRMT PPARGC1A CREB1 TFB1M HCFC1 GABPA TFB2M PPRC1 PPARGC1B MYEF2 CARNOSINE METABOLISM OF GLIAL CELLS%WIKIPATHWAYS_20260810%WP5313%HOMO SAPIENS Carnosine metabolism of glial cells SLC15A2 CARNS1 SLC15A4 NUCLEOTIDE METABOLISM%WIKIPATHWAYS_20260810%WP404%HOMO SAPIENS Nucleotide metabolism POLG SRM OAZ1 NME2 RRM2B ADSL POLA1 IMPDH1 MTHFD2 ADSS RRM1 RRM2 DHFR SPLICING FACTOR NOVA REGULATED SYNAPTIC PROTEINS%WIKIPATHWAYS_20260810%WP4148%HOMO SAPIENS Splicing factor NOVA regulated synaptic proteins GRIK2 STX2 CAMK2G GRIN2B AGRN PRKCZ CLASP1 GPHN MAPK9 GABBR2 CSN3 ATP2B1 KCNQ2 CADM1 CAV2 EFNA5 MAP4 MAPK4 KCNMA1 KCNJ6 RAP1GAP CDH2 CASK GRIN1 PLCB4 CHL1 NCDN NTNG1 CADM3 SNW1 TERF2IP DAB1 NOD LIKE RECEPTOR NLR SIGNALING%WIKIPATHWAYS_20260810%WP288%HOMO SAPIENS Nod like receptor NLR signaling IKBKG MAP3K7 CD40 EPHB2 ERBIN CHUK IKBKB MAPK8 RELA ROTENONE METABOLISM%WIKIPATHWAYS_20260810%WP5486%HOMO SAPIENS Rotenone metabolism CYP3A4 CYP2C19 INTERACTIONS BETWEEN LOXL4 AND OXIDATIVE STRESS PATHWAY%WIKIPATHWAYS_20260810%WP3670%HOMO SAPIENS Interactions between LOXL4 and oxidative stress pathway NQO1 PKD1 IGFBP7 COL2A1 NRF1 LOXL4 DDR1 SIRT1 CDC37 FGF7 EXOC6 TGFB1 SUV39H1 ECSIT BMP2 NFE2L2 HEL-S-7 HEART DEVELOPMENT%WIKIPATHWAYS_20260810%WP1591%HOMO SAPIENS Heart development IRX4 TBX5 ISL1 PITX2 VEGFB FOXH1 VEGFC GATA6 HAND1 MAPK1 BMP10 NOTCH1 BMP2 PTPN11 SHH FOXA2 FGF8 MEF2C HAND2 ERBB3 SMYD1 BHLHB2 BMPR1A VEGFA NFATC3 TBX2 BMP4 SMAD4 NFATC1 SMAD1 GATA4 NFATC4 TBX1 FOXC2 FOXC1 FGF10 TBX20 NFATC2 HEY2 NKX2-5 THYROID HORMONES PRODUCTION AND PERIPHERAL DOWNSTREAM SIGNALING EFFECTS%WIKIPATHWAYS_20260810%WP4746%HOMO SAPIENS Thyroid hormones production and peripheral downstream signaling effects HRAS CREB3 KDM1A WNT4 SOS1 RPS6KA6 PRDM16 UCP1 PLIN1 BAD ADRB3 AKT1S1 ITGB3 ITGAV PFKFB2 THRA NPPB NR1A2 TBC1D4 TRH MC4R TSHR PNPLA2 SLC5A5 NPY ATF2 AgRP FGF21 TG MLST8 ITPR2 DUOX2 TTF2 PPARGC1A TTF1 NHSL1 DUOXA2 POMC SECISBP2L DEHAL1 SLC26A4 FGFR1 FOXO1 CASP9 SLC16A10 ADCY3 ADCY8 MAPKAPK3 SRC MAP2K1 TSHB RHEB TSC2 TSC1 MTOR MAPK1 RAF1 ZNF516 RXRA PAX8 KDM3B NOTCH1 AQP7 MAPK14 SHH RPTOR TPO MGLL AKT3 GSK3B MDM2 RPS6 RPS6KB1 FRS2 ACTL6B SIRT6 PPARG SLCO1C1 SLC16A2 DIO1 MAFA GRB2 PHYSIOLOGICAL AND PATHOLOGICAL HYPERTROPHY OF THE HEART%WIKIPATHWAYS_20260810%WP1528%HOMO SAPIENS Physiological and pathological hypertrophy of the heart MAPK14 EDN1 MAP2K3 CALM1 CAMK2D STAT3 PRKCB PPP3CA MAPK8 ARHA MAPK1 PRKCE RAC1 GATA4 NFATC4 JUN MAPK11 FOS IL6ST CTF1 MYEF2 GASTRIC ACID PRODUCTION%WIKIPATHWAYS_20260810%WP2596%HOMO SAPIENS Gastric acid production MUC6 CBLIF VIP CCK SCT PGA3 GAST PGC PGA5 BRAIN DERIVED NEUROTROPHIC FACTOR BDNF SIGNALING%WIKIPATHWAYS_20260810%WP2380%HOMO SAPIENS Brain derived neurotrophic factor BDNF signaling NFKB1 CYFIP1 NTF3 SYN1 CDC42 STAT1 STAT3 LINGO1 VAV2 TIAM1 CDK5R1 EEF2 PRKAA2 CAMK2A ADAM17 RAP1A PLCG1 CREB1 SIRPA NCAM1 FRS3 DOK5 KCNN2 DOCK3 MAP3K2 KCNA3 MARCKS MAP2K1 NTRK3 PRKAA1 MAP2K2 CAMK4 TSC2 PIK3R2 PIK3R1 MTOR EIF4EBP1 MAPK1 RAF1 EIF4E MAPK3 IRS1 VAV3 ARHG RPS6KA5 RPS6KA1 MEF2C EIF2S2 CSNK2A1 EIF2S1 RPS6 RPS6KB1 CDKL5 STAT5B FOXO3A NFATC4 GRB2 BDNF GABRB3 HRAS APC PPP2CA YBX1 SQSTM1 BAD NGF SHC4 NFKBIA RASGRF1 SHC2 PTPRF SHC3 CRTC1 IGF2BP1 CDH2 NTRK2 SH2B2 SORT1 KIDINS220 GRIN1 SHC1 GRIA3 KSR1 NCK2 TRAF6 GRIN2B SRC NCF1 NCF2 HEL-S-15 RELA MAPK9 CASP3 PTK2B FYN RAC1 MAPK10 JUN GRIP1 RANBP9 ACACB PTPN11 MAPK14 CDK5 GRIA2 GSK3B NCK1 CNR1 IKBKB FRS2 MAPK8 MAPK7 IKBKG CAMK1 MAP2K5 NTRK1 NGFR SH2B1 MAP3K1 CHUK PDPK1 HOST PATHOGEN INTERACTION OF HUMAN CORONAVIRUSES INTERFERON INDUCTION%WIKIPATHWAYS_20260810%WP4880%HOMO SAPIENS Host pathogen interaction of human coronaviruses interferon induction IFIH1 NFKB1 TRAF6 IFNAR2 TLR7 EIF2AK2 TYK2 STAT1 TICAM1 IFNAR1 IRF9 STAT2 JAK1 RIPK1 JUN OAS3 OAS2 NFKBIA MAPK14 MYD88 IKBKB MAPK8 IKBKG IKBKE MAP3K7 MAVS CHUK FOS RIGI TBK1 IRF3 TRAF3 CELIAC DISEASE MECHANISM AND THERAPIES%WIKIPATHWAYS_20260810%WP5562%HOMO SAPIENS Celiac disease mechanism and therapies ITGB7 DHODH ITGA4 IL2 IFNG IL-21 F2RL1 TNF EGFR IL15 TYROBP CAUSAL NETWORK IN MICROGLIA%WIKIPATHWAYS_20260810%WP3945%HOMO SAPIENS TYROBP causal network in microglia LYL1 TGFBR1 GAL3ST4 TCIRG1 GPX1 HEL-S-62p CXCL16 IL13RA1 DPYD SLC7A7 opn PLEK SH2B3 PYCARD IL10RA TNFRSF1B CENTA2 CD84 FKBP15 LOXL3 HCLS1 NCF2 GIMAP2 NPC2 NRROS PPP1R18 IL18 CD37 RNASE6 LGALS9C APBB1IP BIN2 ELF4 SFT2D2 RBM47 IGSF6 ITGAM KCNE3 RGS1 SAMSN1 CYTL1 LHFPL2 GAPT NCKAP1L ITGAX HLX C1QC RPS6KA1 RUNX3 ZFP36L2 CREB3L2 TYROBP MAF HEL-S-66 SYNAPTIC SIGNALING ASSOCIATED WITH AUTISM SPECTRUM DISORDER%WIKIPATHWAYS_20260810%WP4539%HOMO SAPIENS Synaptic signaling associated with autism spectrum disorder GRIN2B SHANK3 HRAS PRKAA1 RHEB PIK3CD HOMER1 CAMK4 PIK3R3 TSC2 TSC1 PIK3R2 PIK3R1 PRKAB2 MTOR PRKAG1 NRAS EIF4EBP1 PRKAG2 MAPK1 PTEN PRKAB1 PRKAG3 MAPK3 SYNGAP1 RPTOR ARC AKT3 GSK3B PRKAA2 UBE3A NTRK2 RPS6KB1 GRIN1 DLG4 NF1 CACNA1C GRIN3B GRIN3A BDNF NETWORK MAP OF SARS COV 2 SIGNALING%WIKIPATHWAYS_20260810%WP5115%HOMO SAPIENS Network map of SARS CoV 2 signaling CCL11 STAT1 CCR6 IL4 CCNB1 JAK1 RRM2 GGH ADAM9 RTN4 CRP CEBPB MOV10 TOMM70 HEL-S-81p CD226 ACE2 IRF9 IFITM3 CPN1 HEL117 GTSE1 APOH VPS36 DKFZp762B153 WDR74 APOM CCR5 HEL103 DEPTOR EIF4A2 HRG CTSZ SERPINA10 RPTOR TPO SDF2 IL16 CXCR1 HMFT1766 OS9 SRP19 HP CLCC1 RPS6 UGCGL2 G3BP2 CD3G NPTX1 CD3E MDN1 TRO TRIM59 ITIH3 ATE1 ATP13A3 FAM98A ZAP70 MIB1 IL6 LCK TF CARD11 TBK1 IL12A HLA-DRB1 HEL-S-130P APOC1 FGA IRAK1 IL13 CD14 HEL-S-78p IL7 NFKB2 CD163 LARP1 MYD88 IL8RB PARP2 AHR CXCL9 CXCL8 RRAS EGR1 ALB CASP8 MLST8 LBP CCL20 VPS18 VPS33A FOS IRF3 TRAF3 VPS16 IL1B HLA-DRB5 TRAF6 BST2 IL5 CXCL12 PIAS1 CCL5 CCL4 VPS41 CCL3 IFNB1 IFNG CCNB2 PTPN6 CDC2 TLE3 INTS4 IL22 CXCL13 IL-21 C1QBP CCL21 CXCL3 NRF PRG3 IL17A CD2 CFH CFI NTRK1 HBB SRP54 HBD IFI27 CXCL16 GABARAPL2 OAS2 AKT1S1 IL9 APOL1 CXCL6 MMP25 GP1BA COQ8B CCL8 CCL1 CFB CCL22 PTGS2 CCL27 CCL15 CCL26 CXCL2 CASP9 CASP5 FAM83A NLRP3 NLRP1 RHEB IL18 CAMK4 MTOR EIF4EBP1 TNFSF10 EIF4E JUNB GTF2F2 ACTG1 NFATC3 ITCH MAVS APOA2 RIGI PRKCQ HEL-S-72p IFIH1 IL18RAP TGFBR2 IL1R2 BIRC5 SAA1 SAA2 NEK9 APOD IL33 CXCL1 TP53I3 CXCL5 DKFZp781O1323 CD8B CD8A SMAD1 PS1TP5BP1 ITIH4 TNF CASP3 TRPM2 CCL2 FYN RAC1 PMPCB SELP IL10 PF4 C1S IFITM1 CFP JUN IFI6 C8A MX1 IFIT1 HIF1A IGLL1 IL1A CTSL PITRM1 STEAP3 FGF2 MAPK8 TRAF2 IKBKG DDIT4 ULK1 LGALS3BP TBKBP1 NANOMATERIAL INDUCED APOPTOSIS%WIKIPATHWAYS_20260810%WP2507%HOMO SAPIENS Nanomaterial induced apoptosis HTRA2 PRF1 APAF1 BAK1 CASP3 CASP8 AIFM1 CASP6 BAX TNFSF6 DIABLO BCL2 FADD CYCS CASP9 MET IN TYPE 1 PAPILLARY RENAL CELL CARCINOMA%WIKIPATHWAYS_20260810%WP4205%HOMO SAPIENS MET in type 1 papillary renal cell carcinoma STRN JAK3 SRC HRAS MAP2K1 MAP2K2 PIK3CD CDC42 PIK3R3 PAK1 STAT3 PRCC PIK3R2 SOS1 PIK3R1 SOS2 KDR NRAS MAPK1 ALK BAD RAF1 RAC1 JUN MAPK3 PTPN11 RAPGEF1 ARAF AKT3 CRKL HGF MAPK8 RAP1A CBL CRK RPL11 VEGFA PAK6 INSL3 C8orf34 PAK4 PLCG1 BRAF GRB2 ELOA CDKN1A EXRNA MECHANISM OF ACTION AND BIOGENESIS%WIKIPATHWAYS_20260810%WP2805%HOMO SAPIENS exRNA mechanism of action and biogenesis AGO2 XPO5 DROSHA DGCR8 ERI1 DICER1 KALLMANN SYNDROME%WIKIPATHWAYS_20260810%WP5074%HOMO SAPIENS Kallmann syndrome FGF8 ASCL1 LHB OLIG2 SOX10 NEUROG1 PLXND1 MAP2K2 PROK2 FRS2 MYRF MAPK1 SEMA3E TMEM98 OTX2 GRB2 FGFR1 ANOS1 GNRH1 PTPN11 EFFECTS OF NITRIC OXIDE%WIKIPATHWAYS_20260810%WP1995%HOMO SAPIENS Effects of nitric oxide AOX1 XDH NOS2 COX1 HBB HBA2 KLEEFSTRA SYNDROME%WIKIPATHWAYS_20260810%WP5351%HOMO SAPIENS Kleefstra syndrome NR1I3 EHMT1 PAXIP1 KMT2C ASH2L NCOA6 SMARCD1 MBD5 SMARCD2 SMARCD3 WDR5 ACTL6B PAGR1 ASXL1 SMARCC1 DPY30 SMARCC2 SMARCA4 RXRA ARID1B ARID1A BAP1 H3F3B ACTL6A SULFATION BIOTRANSFORMATION REACTION%WIKIPATHWAYS_20260810%WP692%HOMO SAPIENS Sulfation biotransformation reaction SULT1C3 SULT2B1 SULT1C4 SULT1A1 SULT6B1 SULT1E1 SULT2A1 PAPSS2 SULT1A4 HEL-75 SULT1A2 PAPSS1 SULT1B1 SULT1C2 ADIPOGENESIS%WIKIPATHWAYS_20260810%WP236%HOMO SAPIENS Adipogenesis IGF1 MIXL1 PCK1 BMP1 SFRP4 STAT1 OSM NR1H3 STAT3 UCP1 IRS4 SOCS1 NR1C1 ASIP NR1C2 BMP2 GH1 SP1 NR2F1 RBL2 BSCL2 CFD RBL1 CEBPA PNPLA3 CEBPB HMGA1 NR3C1 CNTFR MEF2B E2F4 MBNL1 NDN RETN PRLR GATA4 CREB1 SCD FOXO1 CYP26B1 CYP26A1 HNF1A LIF DDIT3 TWIST1 RXRA TRIB3 IRS1 INS RORA MEF2C WNT1 BMP3 LEP STAT5B GATA3 EGR2 NCOR2 GATA2 BMP4 WNT5B IL6 CISD1 NAMPT GTF3A ADFP SPOCK1 LPL KLF7 RARA CDKN1A KLF15 DVL1 GDF10 FZD1 WNT10B LIPE PLIN1 STAT2 MEF2D AHR NCOA1 SOCS3 PPARGC1A LPIN1 LPIN2 IL6ST FOXC2 SLC2A4 RB1 CEBPD LPIN3 TNF PTGIS WWTR1 ID3 KLF6 GADD45B GADD45A HIF1A RXRG PCK2 NCOR1 ZMPSTE24 LMNA PPARG FRZB TGFB1 CELF1 KLF5 OXYSTEROLS DERIVED FROM CHOLESTEROL%WIKIPATHWAYS_20260810%WP4545%HOMO SAPIENS Oxysterols derived from cholesterol ACOT9 ACOT8 ACOT7 CYP46A1 ACOT11 ACOT12 ACOT13 EBP AMACR GPR183 THEM5 SULT2B1 ACOT6 SLC27A2 HSD3B7 ACOT4 CYP7A1 CH25H AKR1D1 SULT2A1 CYP7B1 CYP27A1 BAAT NR1i2 DHCR7 DBP AKR1C4 CYP8B1 CYP3A4 INSIG1 RORC SLC27A5 IL17A EPHX2 LBP NR1H2 IL17F IL17D HSD11B1 IL17C HSD11B2 IL17B NR3A2 ROS IN COVID 19 ENDOTHELIAL DYSFUNCTION%WIKIPATHWAYS_20260810%WP5258%HOMO SAPIENS ROS in COVID 19 endothelial dysfunction NFKB1 ACE2 IFNAR1 TNFRSF1A TNF IFNA1 MIR TARGETED GENES IN ADIPOCYTES%WIKIPATHWAYS_20260810%WP2001%HOMO SAPIENS miR targeted genes in adipocytes TMED10 CYP1B1 CAP1 IGF2R CEBPB TGFBR2 TMEM43 FADS1 PICALM LPL PHC2 ELOVL5 SRSF10 SRSF9 DEVELOPMENT OF PULMONARY DENDRITIC CELLS AND MACROPHAGE SUBSETS%WIKIPATHWAYS_20260810%WP3892%HOMO SAPIENS Development of pulmonary dendritic cells and macrophage subsets TPO BATF3 TCF4 SPI1 CSF2 IKZF1 GIG8 STAT3 IRF4 FLT3LG CSF1 RUNX2 IRF8 GAMMA GLUTAMYL CYCLE FOR THE BIOSYNTHESIS AND DEGRADATION OF GLUTATHIONE%WIKIPATHWAYS_20260810%WP4518%HOMO SAPIENS Gamma glutamyl cycle for the biosynthesis and degradation of glutathione GCLC OPLAH HEL-S-64p GGCT TRYPTOPHAN KYNURENINE PATHWAY IN POST COVID SYNDROME%WIKIPATHWAYS_20260810%WP5549%HOMO SAPIENS Tryptophan kynurenine pathway in post COVID syndrome IL1B KYAT3 KYAT1 DDC GOT2 AHR IFNA6 AADAT TNF HAAO KMO TDO2 KYNU AFMID IFNB1 IFNG IDO2 IDO1 IL6 SHANK3 PATHWAY INVOLVED IN PHELAN MCDERMID SYNDROME%WIKIPATHWAYS_20260810%WP5566%HOMO SAPIENS SHANK3 pathway involved in Phelan McDermid syndrome PS1TP5BP1 LZTS3 SPTAN1 GRIN2B SHANK3 HRAS CDC42 HOMER1 PAK1 BAIAP2 SYNGAP1 ITGB1 ADGRL1 GRIA2 DLGAP1 CAMK2A GRIN1 RAP1A ARHGEF7 DLG4 MAP3K7 HCN1 CTNND2 SPAAR ARHGAP44 SHARPIN